bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intimate partner violence and health system response in Nekemte town, Western Oromia, Ethiopia, 2019: A cross-sectional study
Authors: Wodajo Etenesh , Gutema Edosa Amente , Mulatu Befirdu , Assefa Lemessa , Moges Muluken 
Published: October 2022

Objectives: To assess intimate partner violence and health system response among married women. Methods: A mixed method of quantitative and qualitative cross-sectional community-based study was conducted from August to September 2019. Later than ethical clearance, the data were collected using a pretested structured questionnaire adapted from the literature. Study participants were selected using systematic random sampling. Data collected is entered into EpiData and then exported to SPSS version 25 for analysis. The odds ratio with their 95% confidence interval was calculated. Variables with p-value < 0.25 in bivariate analysis were entered into multivariate logistic regression. Statistical significance was declared if the p-value was <0.05. Results: From all 770 sampled participants in Nekemte town, 730 married women participated in this study, yielding a response rate of 94.8%. The prevalence of intimate partner violence was 55.9%. From this study finding, no intimate partner violence screening was done for 678 (92.9%) respondents who visited health facilities. Educational status of women, partner being illiterate, occupational status being merchant, and daily laborer were associated with intimate partner violence with (adjusted odds ratio = 1.73, 95% confidence interval = (1.05–2.83)), (adjusted odds ratio = 5.94, 95% confidence interval = (1.25–12.23)), (adjusted odds ratio = 4.41, 95% confidence interval = (1.49–13.01)), and (adjusted odds ratio = 3.74, 95% confidence interval = (1.33–10.50)), respectively, were factors found to be associated with intimate partner violence Nekemte town. One of the study participants whose age was 36 years responded that, “our culture approves men’s superiority; we accept intimate partner violence as part of our marital life.” There is an assigned focal person and training was given to them, but screening of intimate partner violence has not started yet and it was not integrated into any maternal service in our health center. Conclusion: This study shows that in excess of half of women experience intimate partner violence. Educational status, occupation and violence seen during childhood were the factors that contributed to intimate partner violence. Educating women and partners, integrating, and strengthening a health service are important.
Comparison of different methods for evaluating the relationship between facial nerve and benign parotid tumors
Authors: Kojima Takashi , Matsumoto Fumihiko , Suzuki Yo , Sakyo Airi , Kojima Masataka , Fujimaki Mitsuhisa , Ohba Shinichi 
Published: October 2022

Objectives: The goals of benign parotid gland tumor resection are complete resection of the lesion and preservation of the facial nerve function. As the facial nerve cannot be directly visualized via imaging modalities, several methods, including the facial nerve line, Utrecht line, retromandibular vein, Stenon duct, and minimum fascia-tumor distance techniques, have been developed to estimate its location. However, there are no reports on their accuracy in determining tumor location. In the present study, we aimed to assess the diagnostic accuracy of these methods based on tumor location. Methods: This retrospective study analyzed medical records and histological reports of 359 patients with various types of benign parotid gland tumors who underwent a parotidectomy between April 2014 and March 2020. The tumor location was subdivided into the following sections: anterior, superior, inferior, and middle. The tumor location was estimated using five methods: facial nerve line, Utrecht line, retromandibular vein, Stenon duct, and minimum fascia-tumor distance. The final diagnosis of superficial or deep lobe tumor was made based on surgical findings. Results: Each method showed a higher accuracy for superficial tumors (was more than 90%) than for deep lobe tumors. In contrast, for deep lobe tumors, the accuracy of diagnosis with the facial nerve line, Utrecht line, and retromandibular vein methods was low, in the 30% range. Among all methods, the Stenon duct method had the highest accuracy in the diagnosis of deep lobe tumors. The SD method was most useful in cases where both the duct and tumors were detected. The minimum fascia-tumor distance method had the second highest diagnostic accuracy (63%); however, for anterior tumors, it tended to provide false negatives. Conclusions: All tested methods were useful in diagnosing superficial lobe tumors; however, they were not helpful in diagnosing deep lobe tumors, especially anterior tumors.
The Effect of Sintering Procedures on Fit and Color in Zirconia Crowns
Authors: Albayrak Haydar , Eraslan Ravza , Temizkanli Ozan , Sahin Bahar Sayin , Ayata Mustafa , Sezer Taygun 
Published: October 2022

Purpose:The aim of this study was to examine the effects of various sintering procedures on the color parameters, marginal, and internal fit of zirconia crowns.Materials and Methods:Overall, 60 zirconia crowns were produced using 3 distinct zirconia blocks (Wieland Zenostar, Zirkonzahn Ice Translucent, and Zirkonzahn Prettau). For the sintering procedure of the crowns, six groups were created as follows: Wieland-Standard, Wieland-Speed, Ice-Standard, Ice-Speed, Prettau-Slow, and Prettau-Standard programs. The crowns were assigned into groups ( n = 10 in each group). The color parameters, marginal fit, and internal fit of the crowns were evaluated. The normality of data distribution was evaluated with the Kolmogrov–Smirnov test. Two independent samples t-test and Mann–Whitney U test were used to compare the sintering groups.Results:Acceleration of sintering caused a significant change in the color parameters of the Wieland and Ice groups but not in the Prettau group. In the Wieland group, marginal ( p = .047) and internal ( p = .004) gap values of speed sintering were found to be significantly lower than those in standard sintering. In the Ice group, the marginal gap values of speed sintering were found to be significantly lower than those in standard sintering ( p = .019). In the Prettau group, the marginal gap values of standard sintering were found to be significantly higher ( p = .035) than those in slow sintering.Conclusions:It was concluded that the effects of sintering procedures on color parameters, and internal and marginal fit of zirconia crowns were clinically insignificant. Speed sintering can be recommended for zirconia restorations.
Income-related spatial concentration of individual social capital in cities
Authors: Kovács Ádám J , Juhász Sándor , Bokányi Eszter , Lengyel Balázs 
Published: October 2022

Social connections that span across diverse urban neighborhoods can support prosperity by mobilizing social capital. However, there is limited evidence on the spatial structure of individual social capital inside cities. This paper demonstrates that social capital measured by online social connections is spatially more concentrated for residents of lower-income neighborhoods than for residents of higher-income neighborhoods. We map the micro-geography of individual online social networks in the 50 largest metropolitan areas of the United States using a large-scale geolocalized Twitter dataset. We analyze the spatial dimension of individual social capital by the share of friends, closed triangles, and share of supported ties within circles of short distance radii (1, 3, 5, and 10 km) around users’ home location. We compare residents from below-median income neighborhoods with above-median income neighborhoods, and find that users living in relatively poorer neighborhoods have a significantly higher share of connections in close proximity. Moreover, their network is more cohesive and supported within a short distance from their home. These patterns prevail across the 50 largest US metropolitan areas with only a few exceptions. The found disparities in the micro-geographic concentration of social capital can feed segregation and income inequality within cities constraining social circles of low-income residents.
Spontaneous regression of cervical intraepithelial neoplasia 3 in women with a biopsy—cone interval of greater than 11 weeks
Authors: Bruno Maria Teresa , Cassaro Nazario , Mazza Gabriele , Guaita Arianna , Boemi Sara 
Published: October 2022

AbstractBackgroundAlthough there is broad consensus that only a subset of CIN3 will progress to cancer, there is currently no surefire way to predict which CIN3 will regress. Understanding the natural history of CIN3 is important, and finding markers for progression or regression could improve treatment strategies. According to the guidelines of the American Society for Colposcopy and Cervical Pathology of 2006, positive CIN3 p16 in women should be managed with excisional treatment (LEEP). For ethical reasons we cannot fail to treat women with CIN3 in order to study their regression capacity so we conducted a retrospective study to evaluate the regression rate of CIN3 diagnosed with a biopsy by studying the histological result of the cone removed by LEEP. We also investigated age, HPV genotypes and biopsy-cone interval distance as possible regression factors.MethodsWe selected 171 women with a histological diagnosis of positive CIN3 p16 as an entry criterion. All patients underwent LEEP / biopsy. A histological diagnosis of the cone of CIN3 or higher was considered as persistence or progression, the diagnosis of CIN1 or lower was considered as regression of the lesion.We used out a logistic model to study the probability of spontaneous regression of CIN3 as a function of the patient’s age, the time elapsed between the biopsy and the cone (in weeks) and the HPV genotype.ResultsWe found that the spontaneous regression rate of CIN3 was 15,8%, which was strongly associated with the biopsy-cone interval > 11 weeks. Genotype 16, the most represented, was present both in cases of regression (77.8%) and in persistence (83.3%). Regarding age, the estimated odds ratio of the probability of observing a regression in women over 25 years of age was 0.0045 times that of women under 25 years of age (CI: 0.00020, 0.036). Neither age nor viral genotype are significant as predictors of regression.ConclusionTo wait at least 11 weeks from the biopsy before subjecting the woman to LEEP could prevent unnecessary LEEP procedures, considering also that from CIN3 to carcinoma it takes years before the neoplastic transformation takes place.
Padres Preparados, Jóvenes Saludables: intervention impact of a randomized controlled trial on Latino father and adolescent energy balance-related behaviors
Authors: Baltaci A. , Hurtado Choque G. A. , Davey C. , Reyes Peralta A. , Alvarez de Davila S. , Zhang Y. , Gold A. , Larson N. , Reicks M. 
Published: October 2022

Abstract
Background
Studies have shown associations among food and activity behaviors and body weight of Latino fathers and adolescents. However, few Latino father-focused interventions have been designed to improve energy balance-related behaviors (EBRBs) and weight status among early adolescents. Thus, this efficacy study aims to evaluate the Padres Preparados, Jóvenes Saludables (Padres) youth obesity prevention program for positive changes in EBRBs (fruit, vegetable, sugar-sweetened beverage (SSB), sweet/salty snack, and fast-food consumption, physical activity, and screen time) and weight status among low-income Latino fathers and adolescents (10-14 years).

Methods
A two-arm (treatment versus delayed-treatment control group) randomized controlled trial was conducted to evaluate the efficacy of 8 weekly experiential learning sessions (2.5 hours each) based on social cognitive theory. The sessions included food preparation, parenting skills, nutrition, and physical activity. The program was delivered to father-adolescent dyads (mothers were encouraged to attend) in trusted community-based settings in a Midwest metropolitan area between 2017 and 2019. In March 2020, in-person implementation was discontinued due to COVID-19 pandemic restrictions, which limited the sample size. Father/adolescent dyads were randomized to treatment or control group within each site. Surveys and measurements were completed by fathers and adolescents to assess changes in food and activity behaviors from baseline to post-intervention. Adolescents also completed 24-hour dietary recall interviews at baseline and post-intervention. Intervention effects were assessed using linear regression mixed models adjusted for covariates and accounting for clustering of participants within sites.

Results
Data from 147 father/adolescent dyads who completed at least the baseline data collection were used. No significant differences were observed for baseline to post-intervention changes in adolescents’ and fathers’ EBRBs or weight status between treatment and control groups. Fathers’ SSB and fast food intakes were not statistically significant (p = 0.067 and p = 0.090, respectively).

Conclusions
The Padres program resulted in no significant improvements in adolescent and father EBRBs and weight status. Additional Latino father-focused interventions are needed to examine intervention effects on EBRBs among Latino adolescents.

Trial registration
The Padres Preparados, Jóvenes Saludables study is registered with the U.S. National Library of Medicine, ClinicalTrials.gov Identifier: NCT03469752 (19/03/2018).
Medication use by US patients with pulmonary hypertension associated with chronic obstructive pulmonary disease: a retrospective study of administrative data
Authors: Weiss Tracey J. , Rosen Ramey Dena , Yang Lingfeng , Liu Xinyue , Patel Mahesh J. , Rajpathak Swapnil , Bajwa Ednan K. , Lautsch Dominik 
Published: October 2022

Abstract
Background
Pulmonary hypertension (PH) is a serious complication of chronic obstructive pulmonary disease (COPD). While clinical guidelines recommend specific drug therapies for pulmonary arterial hypertension (PAH), these drug therapies are not recommended for PH due to lung disease.

Methods
This was a retrospective cohort study using the Optum® Clinformatics® Data Mart from January 2009–September 2019. An algorithm was designed to identify adults with ≥ 2 ICD-9-CM or ICD-10-CM diagnosis codes for PH and with ≥ 2 diagnosis codes for COPD. Sensitivity analyses were conducted among subgroups of patients with evidence of a right heart catheterization (RHC) or pulmonary function test (PFT). Patient characteristics, medications used, and durations of use of PAH and COPD medications were analyzed.

Results
A total of 25,975 patients met the study inclusion criteria. Their mean age was 73.5 (SD 10.0) years and 63.8% were female. Medications targeting PAH were prescribed to 643 (2.5%) patients, most frequently a phosphodiesterase-5 inhibitor (2.1%) or an endothelin receptor antagonist (0.75%). Medications for COPD were prescribed to 17,765 (68.4%) patients, most frequently an inhaled corticosteroid (57.4%) or short-acting beta agonist (50.4%). The median durations of use ranged from 4.9 to 12.8 months for PAH medications, and from 0.4 to 5.9 months for COPD medications. Of the subgroup of patients with RHC (N = 2325), 257 (11.1%) were prescribed a PAH medication and 1670 (71.8%) used a COPD medication. Of the subgroup with a PFT (N = 2995), 58 (1.9%) were prescribed a PAH medication and 2100 (70.1%) a COPD medication.

Conclusions
Patients with PH associated with COPD were identified in a US administrative claims database. Very few of these patients received any of the medications recommended for PAH, and only about two thirds received medications for COPD.
The efficacy of minocycline hydrochloride ointment versus iodoform gauze for alveolar osteitis: A prospective cohort study
Authors: Sun Yu-qi , Sun Rui , Zhao Ji-hong 
Published: October 2022

Abstract
Background
Alveolar osteitis (AO) is one of the most commonly encountered complication following tooth extraction, however, to date there is no standard methods of prevention and treatment. The study aims to investigate the efficiency of minocycline hydrochloride ointment (MHO) for the treatment of alveolar osteitis compared with traditional treatment with iodoform gauze (IG).

Methods/design
STROBE checklist was followed to report this study. All patients underwent tooth extraction either in our department or other hospitals, whom presented with postoperative pain, were screened out to meet the inclusion and exclusion criteria of this study about AO. Patients who fulfilled the inclusion criteria were enrolled in our prospective cohort study, and MHO or IG was administered. The Visual analog scale scores were used to assess the pain score of patients. The healing status of the extraction sockets was followed up. Differences in responses between groups were analyzed using Mann-Whitney U tests. Chi-square test was performed to explore the differences in the teeth position of AO.

Results
Of 41,371 patients underwent tooth extraction with post-operative follow-up in our departments, only 20 patients (0.05%) suffered from AO. 31 patients with AO, whose teeth were extracted in other places, were also enrolled. The incidence of AO was significantly higher in third molars than other teeth (P < 0.01). In 28 patients that were treated with MHO, the pain was relieved substantially on day 3 and almost painless on day 7. And only 25% of cases required dressing change more than once. Whilst 23 patients treated with IG, the pain was relieved on day 5, and 56.5% of cases required multiple dressing change. The difference between the two groups of VAS scores had statistical significance during treatment at 8 h, 24 h, 3d, 5d, and 7d. No allergic reaction or further infection occurred.

Conclusion
MHO has a safer and higher therapeutic effect in the treatment of AO compared with traditional treatment with IG. MHO may become a preferred treatment modality for AO.
Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reports
Authors: Dewaswala Nakeya , Chen David , Bhopalwala Huzefa , Kaggal Vinod C. , Murphy Sean P. , Bos J. Martijn , Geske Jeffrey B. , Gersh Bernard J. , Ommen Steve R. , Araoz Philip A. , Ackerman Michael J. , Arruda-Olson Adelaide M. 
Published: October 2022

Abstract
Background
Cardiac magnetic resonance (CMR) imaging is important for diagnosis and risk stratification of hypertrophic cardiomyopathy (HCM) patients. However, collection of information from large numbers of CMR reports by manual review is time-consuming, error-prone and costly. Natural language processing (NLP) is an artificial intelligence method for automated extraction of information from narrative text including text in CMR reports in electronic health records (EHR). Our objective was to assess whether NLP can accurately extract diagnosis of HCM from CMR reports.

Methods
An NLP system with two tiers was developed for information extraction from narrative text in CMR reports; the first tier extracted information regarding HCM diagnosis while the second extracted categorical and numeric concepts for HCM classification. We randomly allocated 200 HCM patients with CMR reports from 2004 to 2018 into training (100 patients with 185 CMR reports) and testing sets (100 patients with 206 reports).

Results
NLP algorithms demonstrated very high performance compared to manual annotation. The algorithm to extract HCM diagnosis had accuracy of 0.99. The accuracy for categorical concepts included HCM morphologic subtype 0.99, systolic anterior motion of the mitral valve 0.96, mitral regurgitation 0.93, left ventricular (LV) obstruction 0.94, location of obstruction 0.92, apical pouch 0.98, LV delayed enhancement 0.93, left atrial enlargement 0.99 and right atrial enlargement 0.98. Accuracy for numeric concepts included maximal LV wall thickness 0.96, LV mass 0.99, LV mass index 0.98, LV ejection fraction 0.98 and right ventricular ejection fraction 0.99.

Conclusions
NLP identified and classified HCM from CMR narrative text reports with very high performance.
Oral arsenic and retinoic acid for high-risk acute promyelocytic leukemia
Authors: Ma Ya-Fang , Lu Ying , Wu Qian , Lou Yin-Jun , Yang Min , Xu Jie-Yu , Sun Cai-Hong , Mao Li-Ping , Xu Gai-Xiang , Li Li , Huang Jian , Wang Huai-Yu , Lou Li-Jiang , Meng Hai-Tao , Qian Jie-Jing , Yu Wen-Juan , Wei Ju-Ying , Li Zhen-Yu , Zhu Xue-Lu , Yan Xiao-Yan , Chen Su-Ning , Jin Jie , Zhu Hong-Hu 
Published: October 2022

AbstractAcute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemotherapy has proven feasible in high-risk patients. We evaluated oral arsenic and ATRA without chemotherapy as an outpatient consolidation therapy and no maintenance for high-risk APL. We conducted a multicenter, single-arm, phase 2 study with consolidation phases. The consolidation therapy included Realgar–Indigo naturalis formula (60 mg/kg daily in an oral divided dose) in a 4-week-on and 4-week-off regimen for 4 cycles and ATRA (25 mg/m2 daily in an oral divided dose) in a 2-week-on and 2-week-off regimen for 7 cycles. The primary end point was the disease-free survival (DFS). Secondary end points included measurable resident disease, overall survival (OS), and safety. A total of 54 participants were enrolled at seven centers from May 2019. The median age was 40 years. At the median follow-up of 13.8 months (through April 2022), estimated 2-year DFS and OS were 94% and 100% in an intention-to-treat analysis. All the patients achieved complete molecular remission at the end of consolidation phase. Two patients relapsed after consolidation with a cumulative incidence of relapse of 6.2%. The majority of adverse events were grade 1–2, and only three grade 3 adverse events were observed. Oral arsenic plus ATRA without chemotherapy was active as a first-line consolidation therapy for high-risk APL.Trial registration: chictr.org.cn number, ChiCTR1900023309.