bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reconfigurable high-speed and low-complexity residue number system-based multiply-accumulate channel filter for software radio receivers
Authors: J. Britto Pari , K. Mariammal , D. Vaithiyanathan 
Published: August 2022

Purpose
Filter design plays an essential role in most communication standards. The essential element of the software-defined radio is a channelizer that comprises several channel filters. Designing filters with lower complexity, minimized area and enhanced speed is a demanding task in currently prevailing communication standards. This study aims to propose an efficient reconfigurable residue number system (RNS)-based multiply-accumulate (MAC) channel filter for software radio receivers.

Design/methodology/approach
RNS-based pipelined MAC module for the realization of channel finite impulse response (FIR) filter architecture is considered in this work. Further, the use of a single adder and single multiplier for realizing the filter architecture regardless of the number of taps offers effective resource sharing. This design provides significant improvement in speed of operation as well as a reduction in area complexity.

Findings
In this paper, two major tasks have been considered: first, the RNS number conversion is performed in which the integer is converted into several residues. These residues are processed in parallel and are applied to the MAC-FIR filter architecture. Second, the MAC filter architecture involves pipelining, which enhances the speed of operation to a significant extent. Also, the time-sharing-based design incorporates a single partial product-based shift and add multiplier and single adder, which provide a low complex design. The results show that the proposed 16-tap RNS-based pipelined MAC sub-filter achieves significant improvement in speed as well as 89.87% area optimization when examined with the conventional RNS-based FIR filter structure.

Originality/value
The proposed MAC-FIR filter architecture provides good performance in terms of complexity and speed of operation because of the use of the RNS scheme with pipelining and partial product-based shift and adds multiplier and single adder when examining with the conventional designs. The reported architecture can be used in software radios.
Genomic differentiation of three pico‐phytoplankton species in the Mediterranean Sea
Authors: Da Silva Ophélie , Ayata Sakina‐Dorothée , Ser‐Giacomi Enrico , Leconte Jade , Pelletier Eric , Fauvelot Cécile , Madoui Mohammed‐Amin , Guidi Lionel , Lombard Fabien , Bittner Lucie 
Published: August 2022

AbstractFor more than a decade, high‐throughput sequencing has transformed the study of marine planktonic communities and has highlighted the extent of protist diversity in these ecosystems. Nevertheless, little is known relative to their genomic diversity at the species‐scale as well as their major speciation mechanisms. An increasing number of data obtained from global scale sampling campaigns is becoming publicly available, and we postulate that metagenomic data could contribute to deciphering the processes shaping protist genomic differentiation in the marine realm. As a proof of concept, we developed a findable, accessible, interoperable and reusable (FAIR) pipeline and focused on the Mediterranean Sea to study three a priori abundant protist species: Bathycoccus prasinos, Pelagomonas calceolata and Phaeocystis cordata. We compared the genomic differentiation of each species in light of geographic, environmental and oceanographic distances. We highlighted that isolation‐by‐environment shapes the genomic differentiation of B. prasinos, whereas P. cordata is impacted by geographic distance (i.e. isolation‐by‐distance). At present time, the use of metagenomics to accurately estimate the genomic differentiation of protists remains challenging since coverages are lower compared to traditional population surveys. However, our approach sheds light on ecological and evolutionary processes occurring within natural marine populations and paves the way for future protist population metagenomic studies.
Insights into the monkeypox virus: Making of another pandemic within the pandemic?
Authors: Chadha Jatin , Khullar Lavanya , Gulati Pallavi , Chhibber Sanjay , Harjai Kusum 
Published: August 2022

AbstractJust when the world started to adapt to the ‘new normal’ amid the coronavirus disease 19 (COVID‐19) pandemic, the world is witnessing the wrath of another viral disease, the monkeypox virus (MPXV). The virus is endemic to African countries, where several outbreaks have been reported in the past. However, the present cases have been reported in non‐endemic countries worldwide. Although MPX is considered to be a self‐limiting disease, recent reports on its incidence have proved otherwise. The 2022 multi‐country MPX outbreak has drawn the attention of global surveillance organizations and epidemiologists to trace its origin; however, there are existing gaps regarding the animal reservoirs, biological implications, and management of MPX. In view of the recent events, the World Health Organization (WHO) has also declared the ongoing MPX outbreak a global health emergency. Hence, the geographically expanding MPXV poses a significant threat to human health and public safety. In this review, the latest insights into the biology of MPXV have been provided by discussing its biological implications on human health, changing epidemiological footprint, and presently available intervention strategies. This review also sheds light on the existing lacunas and possible reasons that may have been responsible for the ongoing MPX outbreak.
The future of working from home in the public sector: What does the evidence tell us?
Authors: Williamson Sue , Pearce Alicia , Connor James , Weeratunga Vindhya , Dickinson Helen 
Published: August 2022

AbstractThe COVID‐19 pandemic created a working from home experiment for the public sector. This paper examines what might happen next as countries move towards a COVID‐normal environment. Since the academic literature on public sector agencies and working from home since the onset of the pandemic is scant, we focus on the non‐peer‐reviewed literature as our evidence base. This paper identifies the main issues public sector agencies need to consider as new ways of working emerge. The key facets are emerging preferences for hybrid working, productivity and remote working, and impacts of working from home on employees, especially gender equality. We highlight a range of emerging challenges, including how to maintain productivity, the need to redevelop employee value propositions to attract and retain employees in this changing landscape, and the risks of proximity bias. We conclude by identifying questions to be addressed in subsequent research.
Effect of dialysate bicarbonate and sodium on blood pH in maintenance hemodialysis—A prospective study
Authors: Sridhar Nagaraja Rao , Chen Ziqiang , Yu Guan , Lambert Judy , Muscarella Mary , Nanjundegowda Madan , Panesar Mandip 
Published: August 2022

AbstractIntroductionThe validity of adjusting dialysate bicarbonate based on pre‐hemodialysis (HD) serum bicarbonate is unclear. There are no studies of the impact of dialysate sodium on blood pH.AimsTo understand the impact of dialysate bicarbonate and sodium on blood pH.MethodsTwo hundred arterialized blood samples were obtained on the third session of HD with four configurations of dialysate: sodium (140, 137 mEq/L) and bicarbonate (38, 32 mEq/L).ResultsThe correlation between pre‐HD serum bicarbonate and pH was modest (r = 0.6). A lower dialysate sodium (p = 0.035) and a higher bicarbonate (p = 0.02) associated with a higher post‐HD blood pH. The frequency of pre‐HD blood pH of <7.4 and a post‐HD blood pH of >7.5 did not differ for samples with serum bicarbonate <22, 22–26, or >26 mEq/L.Discussion/ConclusionsAdjusting dialysate buffer based on pre‐HD serum bicarbonate is unnecessary. A higher bicarbonate and lower dialysate sodium associate with post‐HD alkalemia.
Impact of different processing techniques on the key volatile profile, sensory, and consumer acceptance of black truffle (Tuber melanosporum Vittadini)
Authors: Phong Win Nee , Sung Billy , Cao Zhanglong , Gibberd Mark R , Dykes Gary A. , Payne Alan D. , Coorey Ranil 
Published: August 2022

AbstractFresh truffles which include black truffle (Tuber melanosporum Vittadini) deteriorate and lose aroma rapidly after harvest; therefore, postharvest processing via freeze‐drying or encapsulation is an option to preserve truffle aroma for extended supply. However, the aroma profile that directly affects the truffle quality and consumer acceptance is influenced by processing and producers require processing options that balance processing feasibility with retention of a suitable aroma profile. This study aimed to determine the impact of freeze‐drying and encapsulation on the profile of key volatiles, consumer discrimination, and overall sensory impression (aroma intensity, liking, and acceptability) of processed truffle products compared to the starting material (positive control). The study combined experimental‐scale processing with GC‐MS analysis and consumer sensory evaluation to compare and optimize postharvest processing options. Based on the results, some volatile changes were detected in the processed truffle products compared to the positive control which were aligned with the consumer discrimination (triangle test) and the aroma intensity score (consumer sensory test). Despite some chemical and sensory differences detected, the consumer panel did not have any preference for processed truffle products compared to the positive control. The overall finding indicates the potential value of processing truffles into a natural flavoring ingredient for food application via freeze‐drying or encapsulation, which should be of great interest for the truffle and food industry. According to the correlation analysis, the consumer acceptance of a truffle product may be increased by retaining 1‐octen‐3‐ol and methional, while reducing the amount of p‐cresol in the product.Practical ApplicationThe postharvest process of turning truffles into a food flavoring ingredient may cause undesirable volatile changes that would directly impact the aroma quality and consumer acceptance of the processed truffle products. Hence, the impacts of freeze‐drying and encapsulation on the chemical and sensory profile of truffles were evaluated in this study. Overall, the results of the concurrent instrument and sensory analysis demonstrated that both freeze‐drying and encapsulation are potential options for processing.
The long‐term persistence of tumor necrosis factor inhibitors in patients with moderate to severe immune‐mediated rheumatic diseases: A nation‐wide, population‐based real‐world study
Authors: Huang Jing‐Yang , Leong Pui‐Ying , Ker Amy , Chen Hsin‐Hua , Wei James Cheng‐Chung 
Published: August 2022

AbstractObjectivesWe aimed to compare the long‐term persistence between different tumor necrosis factor‐alpha inhibitors (TNFis) with immune‐mediated rheumatic diseases (IMRD). This study can potentially provide insights into the real‐world evidence regarding safety and effectiveness of TNFi treatment in a Chinese population.MethodsWe enrolled newly diagnosed IMRD patients in this active comparator, retrospective cohort study by using National Taiwan insurance claim datasets. The drug survivals of first‐line TNFi agents, including etanercept, golimumab, and adalimumab were compared. Propensity score matching was conducted to control the confounding effect from the observed covariates. The cumulative proportion of discontinuation was calculated over 5 years. The multiple‐variable regression and propensity score analysis was used for confounding adjustment.ResultsAfter propensity score matching, there were 2267 patients identified in each etanercept, golimumab, and adalimumab group. We observed the 5‐year cumulative proportion of discontinuation was 52.80%, 45.85%, and 56.86% in etanercept, golimumab, and adalimumab, respectively. Compared with golimumab, increase of 31% (95% CI: 20‐43) and 38% (95% CI: 26‐50) risk of discontinuation were observed in etanercept and adalimumab. The factors including female gender, increasing age, long hospital stays, without co‐medication with nonsteroidal anti‐inflammatory drugs or methotrexate were associated were discontinuation of first‐line TNFi treatment.ConclusionGolimumab had better drug survival than etanercept or adalimumab over 5 years of observation in Asian IMRD patients. Gender, age, longer hospital stays, concomitant use of disease‐modifying antirheumatic drugs were associated with survival with TNFis.
Norway: Political Developments and Data in 2021
Authors: BERGH JOHANNES , KARLSEN RUNE 
Published: August 2022

AbstractThe
main political event in Norway in 2021 was the Storting (parliamentary) election in September. After eight years of rule by a Conservative Party/Høyre Prime Minister, the 2021 election was a decisive win for the centre‐left. However, it was a win by a fragmented group of five parties, only two of which ended up forming the new government. Despite the new large centre‐left majority in Parliament, the new government, like the previous one, is a minority government. The Covid‐19 pandemic dominated Norwegian life through much of 2021, with two large‐scale lockdowns early in the year and in December. While the last (December) lockdown was a bit controversial, the government's handling of the pandemic was largely depoliticized. The main issues for voters in the election were environmental issues (including climate change). The pandemic did not register as an important issue among voters.
Inflammatory and immune markers in HIV‐infected older adults on long‐term antiretroviral therapy: Persistent elevation of sCD14 and of proinflammatory effector memory T cells
Authors: Watanabe Makiko , Jergovic Mladen , Davidson Lisa , LaFleur Bonnie J. , Castaneda Yvonne , Martinez Carmine , Smithey Megan J. , Stowe Raymond P. , Haddad Elias K. , Nikolich‐Žugich Janko 
Published: August 2022

AbstractHIV‐positive patients whose viral loads are successfully controlled by active antiretroviral therapy (ART) show no clinical signs of AIDS. However, their lifespan is shorter compared with individuals with no HIV infection and they prematurely exhibit a multitude of chronic diseases typically associated with advanced age. It was hypothesized that immune system aging may correlate with, and provide useful biomarkers for, this premature loss of healthspan in HIV‐positive subjects. Here, we tested whether the immune correlates of aging, including cell numbers and phenotypes, inflammatory status, and control of human cytomegalovirus (hCMV) in HIV‐positive subjects on long‐term successful ART (HIV+) may reveal increased “immunological age” compared with HIV‐negative, age‐matched cohort (HIV−) in participants between 50 and 69 years of age. Specifically, we expected that younger HIV+ subjects may immunologically resemble older individuals without HIV. We found no evidence to support this hypothesis. While T cells from HIV+ participants displayed differential expression in several differentiation and/or inhibitory/exhaustion markers in different T cell subpopulations, aging by a decade did not pronounce these changes. Similarly, while the HIV+ participants exhibited higher T cell responses and elevated inflammatory marker levels in plasma, indicative of chronic inflammation, this trait was not age‐sensitive. We did find differences in immune control of hCMV, and, more importantly, a sustained elevation of sCD14 and of proinflammatory CD4 and CD8 T cell responses across age groups, pointing towards uncontrolled inflammation as a factor in reduced healthspan in successfully treated older HIV+ patients.
Rural health service leaders co‐design state‐wide research addressing an emerging health issue: A case report
Authors: Field Michael , Buccheri Alison , King Olivia , Bishop Jaclyn , Wong Shee Anna , Imran Didir , Jacobs Jane , Versace Vincent , Isaacs Anton , Sutton Keith , Sourlos Nick , Murphy Fiona , Kennelly Melissa , Wood Elizabeth , Alston Laura 
Published: August 2022

AbstractAimsThis commentary aims to describe a case of how meaningful co‐design between rural health service leaders and a health service‐embedded research unit can identify emerging research priorities and optimise translation.ContextThe challenges facing rural health services are unique, and the important role of health service leaders in the research response is increasingly recognised. Poorly‐designed research can contribute to research waste through reduced applicability of results to rural communities, and an opportunity exists to increase research co‐designed with rural health services through the involvement of research users during study planning.ApproachIn early 2020, leaders at a rural Victorian health service approached the embedded health service research unit to request research be conducted on an emerging issue: rural staff well‐being in the face of the COVID‐19 pandemic. This was based on their concern regarding the lack of available COVID‐19‐specific evidence to inform organisational policy. In collaboration with the rural health service executive, a translation‐focused study of staff well‐being with nine rural Victorian health services was developed. Key co‐design activities of the project included involving research end‐users as study investigators and conducting formal stakeholder engagement regarding study design and outcomes.ConclusionMeaningful co‐design of research with health services is a multifaceted process that can assist researchers and end‐users alike in identifying and responding to emerging health issues. In the rural setting where there is a vital need for impactful health research, we recommend that researchers should consider employing co‐design processes in order to minimise research waste and optimise the translatability of research findings.
Integrative Bayesian Models Using Post-Selective Inference: A Case Study in Radiogenomics
Authors: Panigrahi Snigdha , Mohammed Shariq , Rao Arvind , Baladandayuthapani Veerabhadran 
Published: August 2022

AbstractIntegrative analyses based on statistically relevant associations between genomics and a wealth of intermediary phenotypes (such as imaging) provide vital insights into their clinical relevance in terms of the disease mechanisms. Estimates for uncertainty in the resulting integrative models are however unreliable unless inference accounts for the selection of these associations with accuracy. In this paper, we develop selection-aware Bayesian methods, which (1) counteract the impact of model selection bias through a “selection-aware posterior” in a flexible class of integrative Bayesian models post a selection of promising variables via ℓ1-regularized algorithms; (2) strike an inevitable trade-off between the quality of model selection and inferential power when the same data set is used for both selection and uncertainty estimation. Central to our methodological development, a carefully constructed conditional likelihood function deployed with a reparameterization mapping provides tractable updates when gradient-based Markov chain Monte Carlo (MCMC) sampling is used for estimating uncertainties from the selection-aware posterior. Applying our methods to a radiogenomic analysis, we successfully recover several important gene pathways and estimate uncertainties for their associations with patient survival times.
Women's decision‐making autonomy in Dutch maternity care
Authors: Vogels‐Broeke Maaike , Cellissen Evelien , Daemers Darie , Budé Luc , de Vries Raymond , Nieuwenhuijze Marianne 
Published: August 2022

AbstractBackgroundA positive childbirth experience is an important outcome of maternity care. A significant component of a positive birth experience is the ability to exercise autonomy in decision‐making. In this study, we explore women's reports of their autonomy during conversations about their care with maternity care practitioners during pregnancy and childbirth.MethodData were obtained from a cross‐sectional survey of women living in The Netherlands that asked about their experiences during pregnancy and childbirth, including their role in conversations concerning decisions about their care.ResultsA total of 3494 women were included in this study. Most women scored high on autonomy in decision‐making conversations. During the latter stage of pregnancy (32+ weeks) and in childbirth, women reported significantly lower levels of autonomy in their care conversations with obstetricians as compared with midwives. Linear regression analyses showed that women's perception of personal treatment increased women's reported autonomy in their conversations with both midwives and obstetricians. Almost half (49.1%) of the women who had at least one intervention during birth reported pressure to accept or submit to that intervention. This was indicated by 48.3% of women with induced labor, 47.3% who had an instrumental vaginal birth, 45.2% whose labor was augmented, and 41.9% of women who had a cesarean birth.ConclusionsIn general, women's sense of autonomy in decision‐making conversations during prenatal care and birth is high, but there is room for improvement, and this appeared most notably in conversations with obstetricians. Women's sense of autonomy can be enhanced with personal treatment, including shared decision‐making and the avoidance of pressuring women to accept interventions.
A translation re-initiation variant in KLHL24 also causes epidermolysis bullosa simplex and dilated cardiomyopathy via intermediate filament degradation
Authors: Vermeer Mathilde C.S.C. , Al-Shinnag Mohammad , Silljé Herman H.W. , Gaytan Antonio Esquivel , Murrell Dedee F. , McGaughran Julie , Melbourne Wei , Cowan Timothy , van den Akker Peter C. , van Spaendonck-Zwarts Karin Y. , van der Meer Peter , Bolling Maria C. 
Published: August 2022

Abstract
This study shows that gain-of-function variants in KLHL24 causing EBS and DCM, do not only originate in the start-codon and suggest that any nonsense-inducing variant affecting nucleotides c.4_84 will likely cause the same effect on protein level and a similar potential lethal phenotype.
Early language outcomes in Argentinean toddlers: Associations with home literacy, screen exposure and joint media engagement
Authors: Medawar Julieta , Tabullo Ángel Javier , Gago‐Galvagno Lucas Gustavo 
Published: August 2022

AbstractThis study aimed to analyse the contribution of mothers' home literacy beliefs and practices and the quantity and quality of screen media exposure on Argentinean toddler's language. In addition, we considered parent–child joint engagement, as well as adult scaffolding behaviours during the use of electronic devices. A total of 465 mothers of 18–36 months old children completed an online survey including: the MacArthur Bates CDI, home literacy, screen exposure, joint engagement and scaffolding questionnaires. We observed positive effects of literacy beliefs, PC times and verbal scaffolding on language outcomes. TV exposure contributed negatively to vocabulary and, along with educational content, to sentence use. Shared reading and screen media experiences can be an opportunity for language stimulation, provided there is dialogue and joint engagement. Passive screen exposure and inadequate content may be detrimental for toddlers' language outcomes, probably by displacement of socially significant interactions.