bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 24-hour interval compression plan: part 2—lifestyle and therapeutic regimens to manage chronic oedema case series
Authors: Bock Karen J , Ehmann J Suzie , Muldoon Jeanette 
Published: February 2022

Objective: The aim of this case series was to retrospectively assess the impact on volume control and patients' quality of life (QOL) when a night-time garment was added to their previous compression regimen for a full 24-hour interval compression plan. Method: Patients who had a history of chronic oedema presented to one of two oedema management centres in the US for treatment for oedema exacerbation and/or suboptimal performance of their current garments. Objective data examined were circumferential limb volume (cm3) measurements and QOL measured with the Lymphoedema QOL Tool (LYMQOL-Leg and LYMQOL-Arm). Subjective comments on functional abilities and perception of improvement with a compression plan that comprised a 24-hour interval were documented. Results: All three patients presented in this case series had a reduction in limb volume and improvement in QOL when their daytime regimen of garments was updated and new night-time garments were added. Their subjective comments indicated improvement in activities of daily living and ease of controlling daytime oedema with a 24-hour interval compression plan. Conclusion: This case series illustrates the need for clinicians to create a partnership with the patient to promote concordance and adherence as part of their individual 24-hour interval compression plan. This partnership allows the plan to be uniquely changed and adjusted to allow each patient to feel in control of refreshing their mood, their skin and their garments.
Healing outcomes and predictors among patients with venous leg ulcers treated with compression therapy
Authors: Aloweni Fazila , Mei Chew Suet , Lixuan Nicole Lee , Fook-Chong Stephanie , Yobas Piyanee , Yuh Ang Shin , Xian Tan Wei , Maniya Sivagame 
Published: February 2022

Objective: This study aimed to compare the healing outcomes between three types of compression therapy—two-layer bandage (2LB), four-layer bandage (4LB), and compression stockings, and to identify the predictors of venous leg ulcer (VLU) healing Method: A retrospective review of the medical records of patients diagnosed with VLU between 2011 and 2016 in Singapore was conducted. Univariate and multivariate analyses were done between healed and unhealed VLU patients at three and six months, based on potential factors, ranging from demographic profile to comorbidities and treatment-related variables. Results: Data from 377 patients' medical records were analysed. The healing rates with the three types of compression system, 4LB, 2LB and compression stockings, were 22.3%, 34.9% and 8.7% respectively at three months; at six months they were 44.2%, 41.9% and 34.8% respectively. Patients on 2LB reported a significantly higher proportion of healed ulcers at three months (p=0.003) but at six months there was no difference in healing rates between the three types of therapy. At three and six months, the duration of compression therapy was found to be an independent predictor of healing (p<0.001). Conclusion: In this study, the 2LB appeared to show the most favourable healing outcome in the short-term but as VLUs persisted beyond the months, the type of compression system used did not make a difference in the healing outcome. Our findings suggested that, as the duration became more prolonged, VLUs became more resistant to healing despite compression therapy. Therefore, it may be necessary for clinicians to consider adjuvant therapies for hard-to-heal ulcers at an earlier stage.
The ReIMAGINE prostate cancer risk study protocol: A prospective cohort study in men with a suspicion of prostate cancer who are referred onto an MRI-based diagnostic pathway with donation of tissue, blood and urine for biomarker analyses.
Authors: Marsden Teresa , McCartan Neil , Brown Louise , Rodriguez-Justo Manuel , Syer Tom , Brembilla Giorgio , Van Hemelrijck Mieke , Coolen Ton , Attard Gerhardt , Punwani Shonit , Moore Caroline M. , Ahmed Hashim U. , Emberton Mark ,   on behalf of the ReIMAGINE Study Group
Published: February 2022

Introduction
The ReIMAGINE Consortium was conceived to develop risk-stratification models that might incorporate the full range of novel prostate cancer (PCa) diagnostics (both commercial and academic).

Methods
ReIMAGINE Risk is an ethics approved (19/LO/1128) multicentre, prospective, observational cohort study which will recruit 1000 treatment-naive men undergoing a multi-parametric MRI (mpMRI) due to an elevated PSA (≤20ng/ml) or abnormal prostate examination who subsequently had a suspicious mpMRI (score≥3, stage ≤T3bN0M0). Primary outcomes include the detection of ≥Gleason 7 PCa at baseline and time to clinical progression, metastasis and death. Baseline blood, urine, and biopsy cores for fresh prostate tissue samples (2 targeted and 1 non-targeted) will be biobanked for future analysis. High-resolution scanning of pathology whole-slide imaging and MRI-DICOM images will be collected. Consortium partners will be granted access to data and biobanks to develop and validate biomarkers using correlation to mpMRI, biopsy-based disease status and long-term clinical outcomes.

Results
Recruitment began in September 2019(n = 533). A first site opened in September 2019 (n = 296), a second in November 2019 (n = 210) and a third in December 2020 (n = 27). Acceptance to the study has been 65% and a mean of 36.5ml(SD+/-10.0), 12.9ml(SD+/-3.7) and 2.8ml(SD+/-0.7) urine, plasma and serum donated for research, respectively. There are currently 4 academic and 15 commercial partners spanning imaging (~9 radiomics, artificial intelligence/machine learning), fluidic (~3 blood-based and ~2urine-based) and tissue-based (~1) biomarkers.

Conclusion
The consortium will develop, or adjust, risk models for PCa, and provide a platform for evaluating the role of novel diagnostics in the era of pre-biopsy MRI and targeted biopsy.
Concordance rate of radiologists and a commercialized deep-learning solution for chest X-ray: Real-world experience with a multicenter health screening cohort
Authors: Kim Eun Young , Kim Young Jae , Choi Won-Jun , Jeon Ji Soo , Kim Moon Young , Oh Dong Hyun , Jin Kwang Nam , Cho Young Jun 
Published: February 2022

Purpose
Lunit INSIGHT CXR (Lunit) is a commercially available deep-learning algorithm-based decision support system for chest radiography (CXR). This retrospective study aimed to evaluate the concordance rate of radiologists and Lunit for thoracic abnormalities in a multicenter health screening cohort.

Methods and materials
We retrospectively evaluated the radiology reports and Lunit results for CXR at several health screening centers in August 2020. Lunit was adopted as a clinical decision support system (CDSS) in routine clinical practice. Subsequently, radiologists completed their reports after reviewing the Lunit results. The DLA result was provided as a color map with an abnormality score (%) for thoracic lesions when the score was greater than the predefined cutoff value of 15%. Concordance was achieved when (a) the radiology reports were consistent with the DLA results (“accept”), (b) the radiology reports were partially consistent with the DLA results (“edit”) or had additional lesions compared with the DLA results (“add”). There was discordance when the DLA results were rejected in the radiology report. In addition, we compared the reading times before and after Lunit was introduced. Finally, we evaluated systemic usability scale questionnaire for radiologists and physicians who had experienced Lunit.

Results
Among 3,113 participants (1,157 men; mean age, 49 years), thoracic abnormalities were found in 343 (11.0%) based on the CXR radiology reports and 621 (20.1%) based on the Lunit results. The concordance rate was 86.8% (accept: 85.3%, edit: 0.9%, and add: 0.6%), and the discordance rate was 13.2%. Except for 479 cases (7.5%) for whom reading time data were unavailable (n = 5) or unreliable (n = 474), the median reading time increased after the clinical integration of Lunit (median, 19s vs. 14s, P < 0.001).

Conclusion
The real-world multicenter health screening cohort showed a high concordance of the chest X-ray report and the Lunit result under the clinical integration of the deep-learning solution. The reading time slight increased with the Lunit assistance.
Tamizaje neonatal y enfermedades raras. Del test de Guthrie a la espectrometría de masas
Authors: Bermúdez Antonio José , Robayo Dora Beatriz , González Nohora , Moreno Ana Lida 
Published: February 2022

Antecedentes: el tamizaje neonatal comienza con la Fenilcetonuria, la primera enfermedad metabólica en ser detectada mediante el test de Guthrie, un ensayo de inhibición bacteriana. Actualmente se tamizan más enfermedades metabólicas con espectrometría de masas en tandem. Las enfermedades objeto de tamizaje neonatal varían de un país a otro, pero existe un consenso internacional sobre cuáles cumplen los criterios de la Organización Mundial de la Salud. Colombia se adhiere a este consenso, bajo la ley 1980 de 2019. Las patologías objeto de tamizaje neonatal se definen en dos grupos, el tamizaje básico y el tamizaje ampliado, que comprende los errores innatos del metabolismo de los aminoácidos y los ácidos orgánicos incluidos los desórdenes de la beta oxidación de ácidos grasos. Tema: aunque mucho va del test de Guthrie a la Espectrometría de Masas en tándem y se cuenta con avances en tamizaje de hipotiroidismo congénito, el reto actual es tener laboratorios con capacidad para dar respuesta al diagnóstico de Enfermedades raras y particularmente al tamizaje neonatal. La mayoría son de etiología genética, lo cual se refleja en que las pruebas para diagnóstico y seguimiento son moleculares, incluso la prueba Gold estándar. Solo algunas de las enfermedades raras son objeto de Tamiz neonatal, requieren pruebas que se distribuyen entre pruebas genéticas moleculares y pruebas bioquímicas complejas, tanto instrumentales como enzimáticas. Conclusiones: el Laboratorio clínico puede hacer las pruebas iniciales de Tamiz Neonatal, pero las pruebas confirmatorias y de seguimiento, son complejas y posiblemente requieran la confluencia en redes, de diferentes laboratorios especializados.
Holoprosencefalia de tipo recesivo en una familia endogámica Colombiana.
Authors: Zannin Andreina , Celis Luis Gustavo , Fernández Isabel , Ossa Humberto , Garzon María Camila , Mayorga Samantha , Murillo Luz Ángela , Zuleta Paola Gabriela 
Published: February 2022

La holoprosencefalia es una anomalía congénita cerebral compleja resultante de una división incompleta del prosencéfalo, generando una ausencia total o parcial de la separación de los hemisferios cerebrales, manifestándose clínicamente en diferentes malformaciones craneofaciales.
En el presente artículo se presenta el caso de una recién nacida femenina, en quien se realizó una historia clínica y examen físico completo, observándose características fenotípicas principales de esta anomalía congénita al igual que muestras sanguíneas y estudios complementarios.
Esta patología tiene una etiología heterogénea, variada y son pocos los casos relacionados con un herencia autosómica recesiva por lo que es importante apostar por un diagnóstico temprano prenatal y brindar un asesoramiento multidisciplinario y genético dando una adecuada información a los padres.
Quiste de duplicación esofágica en un paciente pediátrico, reporte de caso.
Authors: Oliveros Andrade Oskar Andrey , Peña Pedraza María Paula , Orozco García Freddy Arturo , Melo Carlos Alberto 
Published: February 2022

Antecedentes: los quistes de duplicación esofágica son de baja incidencia en pediatría. La disfagia es la principal manifestación clínica. Pueden ser asociados a otras malformaciones. El diagnóstico debe reunir características imagenológicas y debe ser confirmado con hallazgos histopatológicos. El tratamiento en casos sintomáticos es quirúrgico para evitar complicaciones. El objetivo de este es sensibilizar al lector sobre un diagnóstico que debe ser tenido en cuenta en el estudio de disfagia, para realizar su diagnóstico temprano y tratamiento oportuno evitando complicaciones. Resumen del caso: paciente de 11 años con disfagia de 2 años de evolución, sin otros síntomas asociados, sin antecedentes de importancia, sin otras malformaciones asociadas. Dentro del estudio de disfagia se le realiza endoscopia de vías digestivas altas y se identifica lesión que comprime de forma extrínseca el esófago en su parte distal, pudiendo corroborarse con estudios imagenológicos adicionales. Se le realizó resección completa por videotoracoscopia y se confirmó sospecha diagnóstica de quiste de duplicación esofágica por hallazgos histopatológicos. Se pudo dar egreso sin complicaciones. Conclusiones: los quistes de duplicación esofágica del tercio inferior del esófago por lo general son asintomáticos, sin embargo, en algunas ocasiones pueden causar síntomas inespecíficos. Deben sospecharse dentro de los diagnósticos diferenciales de pacientes con disfagia, estudiarse con diagnósticos imagenológicos y confirmándose con hallazgos histopatológicos. La resección quirúrgica es el tratamiento de elección y de realizarse a tiempo para evitar complicaciones.
Frecuencia de malformaciones congénitas renales y del tracto urinario y su asociación con factores maternos y del neonato.
Authors: Atehortúa  Baena Pahola , Mejia Mesa Susana , Arango Gutierrez Laura , Carvalho Saldarriaga Santiago , Morales Ospina Vanessa , Rodriguez Padilla Libia María 
Published: February 2022

Introducción: las malformaciones congénitas del riñón y del tracto urinario, son muy frecuentes y representan la principal causa de insuficiencia renal crónica en los niños. Objetivo: estimar la frecuencia de malformaciones congénitas del riñón y del tracto urinario y su relación con factores maternos y neonatales. Métodos: estudio cohorte retrospectiva. Se recolectaron variables sociodemográficas y clínicas, tales como edad, sexo, diabetes, hipertensión, obesidad y alteraciones en el volumen del líquido amniótico, edad gestacional y peso del niño. Se estableció la asociación entre estos factores y las malformaciones renales congénitas, utilizando la prueba chi cuadrado o test de Fisher. Se estimaron los riesgos relativos con sus respectivos intervalos de confianza y se ajustaron utilizando una regresión binomial. Resultados: se incluyeron 2 137 pacientes; 54.4 % eran hombres, la mediana de edad gestacional fue de 38.8 semanas, rango intercuartíl de: 37.57 – 39.71). La mediana de edad materna fue 26 años, rango intercuartíl de: 21 – 30); 67 neonatos (3.1 %) presentaron alguna malformación, siendo la dilatación del tracto urinario la más frecuente en 59 pacientes (93.6 %). Los factores maternos como el polihidramnios y oligohidramnios demostraron tener asociación con la aparición de las malformaciones. Conclusión: La frecuencia de las malformaciones fue alta en comparación con lo reportado en la literatura. Se encontró como factores asociados significativos las alteraciones en la cantidad del líquido amniótico, especialmente el polihidramnios.
Monitoring Flexure Behavior of Compacted Clay Beam Using High-Resolution Distributed Fiber Optic Strain Sensors
Authors: Li Hao-Jie , Zhu Hong-Hu , Zhang Chun-Xin , Reddy Narala Gangadhara , Garg Ankit , Wu Hai-Ying 
Published: February 2022

Abstract
Understanding the mechanical characteristics of clayey soil is critical to estimate the stability of clay-related geotechnical engineering works. However, the distributed information of the internal deformation of clay is hard to capture through traditional methods. In this paper, a set of four-point bending tests were performed on a compacted clay beam instrumented with fiber optic strain sensors to investigate the flexure and cracking behaviors. The optical frequency domain reflectometry technique with high spatial resolution and precision was employed to establish a distributed strain sensing (DSS) system in this study. The results show that the DSS system exhibits a high accuracy in the collection of the clay deformation in terms of compression, tension, and cracking. The comparison of the internal strain profiles with the observation of particle image velocimetry analysis system verifies the feasibility of fiber optic sensing technology in the quantitative assessment of clay deformation. The performance of fiber optic sensors in the rebound deformation and creep deformation monitoring was preliminarily issued in the study. In addition, the progressive failure on the fiber–soil interface was analytically studied to evaluate the deformation compatibility between the fiber and surrounding clayed soil. The conclusions drawn in this paper can help to guide the state interpretation of clayey soil instrumented with fiber optic sensors.
Development of a New Dynamic Test Method to Determine the Wind Pressure Resistance of Photovoltaic Roof Assembly (PVRA)
Authors: Molleti Sudhakar , Chavez Mauricio , Ramful Chundra , Ko Steven 
Published: February 2022

Abstract
Commercial rooftops provide extensive areas that represent the ideal platform to install a photovoltaic (PV) system. The combination of the roofing assembly and the PV system is termed a photovoltaic roofing assembly (PVRA). There was little guidance for determining the wind loads on rooftop PV systems for many years. With the efforts of the Structural Engineers Association of California and numerous wind tunnel studies conducted by reputed labs, the design methodology for determining wind loads on PV systems has been established, which has become ASCE 7-16, Minimum Design Loads for Buildings and Other Structures, and the National Building Code of Canada 2015. However, there is no guidance on the resistance aspect of the PVRA. During the life cycle of the rooftop solar array, the variable amplitude of the dynamic wind loading can lead to fatigue, which can accumulate damage in structure details. Such damages might lead to severe failures in the whole PVRA. Currently, there are no standardized test methods that determine the collective performance of a PVRA. In collaboration with the roofing and solar industry, the National Research Council Canada (NRC) is conducting a research study to address the missing link between the design and resistance of a PVRA. A unique, dynamic test method was developed to determine the wind pressure resistance of a PVRA. The test methodology applies uniform wind pressure on a 3 × 3 array. It provides a complete load path evaluating the capacity in members, connections, and PV attachments to the roof assembly. The current paper presents the PVRA test apparatus commissioning process. It details the experimental apparatus, the definition of the testing specimen, the establishment of a dynamic loading protocol, and quantification (measurements) of the system response. It also presents the results of pilot testing conducted as per the new test method. Once standardized, this new protocol will ensure that PVRA integrity is maintained and PV performance is optimized.
STATUS ASET PENGHIDUPAN NELAYAN DESA IGAL KECAMATAN MANDAH KABUPATEN INDRAGIRI HILIR
Authors: Juliani Saskia , Kusai Kusai , Warningsih Trisla 
Published: February 2022

Kecamatan Mandah, Kabupaten Indragiri Hilir merupakan daerah yang mempunyai sumber daya alam cukup melimpah namun memiliki masalah pada kerusakan lingkungan dan degradasi sumber daya alam. Penelitian ini bertujuan mengkaji atau melihat kondisi aset penghidupan masyarakat nelayan dan menentukan status dari aset penghidupan nelayan tersebut. Data yang digunakan adalah data primer dan sekunder berdasarkan teknik wawancara dan pengamatan secara langsung. Analisis data menggunakan pendekatan penghidupan berkelanjutan dengan indikator sumber daya manusia, keuangan, alam dan sosial. Kesejahteraan nelayan secara menyeluruh dilihat dari perhitungan status aset penghidupan berdasarkan pendekatan kehidupan berkelanjutan. Hasil penelitian menyebutkan bahwa indeks penghidupan nelayan pada kategori sedang 50,6; aset keuangan pada kategori sedang 18,3; aset alam dengan kategori kurang baik 3,96; aset sosial pada kategori sedang 16; aset sumber daya manusia kategori baik 12,35 dan fisik 28 dengan kategori sedang. Dengan demikian penghidupan yang ada di Desa Igal cukup baik untuk menopang kesejahteraan nelayan dilihat dari aset-aset yang masih menjanjikan. Tittle: Livelihood Assets Status of Igal Village Communities, Mandah Sub Regency, Indragiri Hilir RegencyMandah Sub-regency of Indragiri Hilir has abundant natural resources in spite of its environmental damage and natural resource degradation. This study aims to examine the condition of livelihood assets of fishing communities and determine the status of livelihood assets of these fishers. The study used primary and secondary data from interview and direct observation. Data were analyzed with sustainable livelihoods approach with several indicators of human, financial, natural and social resources. The fishers’ welfare thoroughly measured from the calculation of the status of livelihood assets based on sustainable livelihood approach. The results of the study indicate that the fisher’s livelihood index are in medium category of 50,6, financial asset are in medium category of 18,3, natural assets are in bad category of 3,96, social assets are in medium category of 16, human resource assets are in good category of 12,35 and physical 28 is in medium category.Therefore, the livelihood in Igal Village are fairly well to support the fisher’s welfare from the promising assets.
Nationwide surveillance for S-metoprolol treatment effect on blood pressure control against sympathetic overdrive in Indian patients with hypertension (PROTECT)
Authors: Ramesh D. , Kumar Parminder Singh , Palimkar Priya , Dhoot Krishna , Dabhade Dhammdeep C. , Newale Sanket 
Published: February 2022

Background: Patients with hypertension in India been reported with high heart rate owing to Sympathetic overdrive (SO). Beta-blockers provides several positive effects to reduce SO in patients with hypertension. The aim of the study was to understand current real-world prevalence of SO in Indian patients with hypertension and usage of beta-blocker therapy in them.Methods: A cross sectional, observational, questionnaire-based survey conducted across India between June 2020 to October 2020. A specially designed validated questionnaire was shared with 157 registered Health care practitioners (HCP) and their anonymous inputs were captured and analysed in qualitative manner. Categorical data was summarized by number (n) and percentage (%). Results: Total 157 HCP participated and completed the survey. Around 53% of HCP observed that patients with average heart rate above 75 beats/min were associated with negative prognosis. Around 43% of HCP reported that raised heart rate is associated with advance age and increased Body mass index (BMI). Two-third of HCP reported that tachycardia is associated with stage-2 hypertension and marked by restlessness and anxiety which is suggestive of SO. Over 70% HCP agreed that the HR below 75 beats/min is associated with good prognosis. Around 89% HCP reported beta-blockers as the drug of choice in patients with augmented SO. S-metoprolol was reported to be most preferred beta-blocker agent and recommended by 76% HCP in patients with hypertension and coexisting SO.Conclusions: SO been reported prevalent in Indian patients with hypertension which likely worsen the prognosis in these patients. Beta-blockers reported to be the preferred choice of anti-hypertensive and S-metoprolol seem to be the most preferred agent amongst the available beta-blockers against SO in patients with hypertension in India.