bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Opponensplasty Using Distal Nerve Transfer in High Median Nerve Injuries: a Case Series
Authors: Emamhadi Mohammadreza , Dogahe Mohammad Haghani , Emamhadi Amirreza 
Published: October 2022

Abstract
Purpose
High median nerve injury leads to absence of thumb opposition and irreversible thenar atrophy. Currently, distal nerve transfer is a new option for opponensplasty. The superiority of nerve transfer over traditional tendon transfer is that in nerve transfer, all thenar muscles may be reinnervated and so thumb functions are fully achieved while in tendon transfer, the goal is to reanimate the function of abductor pollicis brevis. This study aims to describe the results of opponensplasty using distal nerve transfer.
Methods
This article analyses the results of opponensplasty using transfer of abductor digiti minimi branch of the ulnar nerve to recurrent branch of the median nerve. Clinical outcomes were assessed by objective evaluation of abductor pollicis brevis (APB) strength, degree of thumb opposition, and thenar muscle bulk. APB strength and degree of thumb opposition measured by Medical Research Council (MRC) and Kapandji scoring systems, respectively.
Results
From 2016 to 2019 six patients of mean age of 29.5 years (five males and one female) with high median nerve injury were considered for opponensplasty using nerve transfer. Clinical improvement including regaining APB strength and thumb opposition was achieved in all patients. Moreover, recovery of thenar atrophy was observed in five patients.
Conclusions
In high median-nerve injury, early reconstructive intervention can prevent the thenar muscle atrophy and leads to prompt reinnervation and complete restoration of thenar function. Abductor digiti minimi branch of the ulnar nerve is a superior donor for this purpose.
MOM-VMP: Multi-Objective Mayfly Optimization algorithm for VM Placement supported by Principal Component Analysis(PCA) in Cloud Data Center
Authors: Durairaj Selvam , Srid Rajeswari 
Published: October 2022

Abstract
Virtual Machine Placement (VMP) is crucial in a cloud data cen-ter(CDC). It is a critical step carried out as part of the Virtual Machine (VM) placement to allocate the best Physical Machine (PM) to host the VMs. The efficacy of the virtual machine placement strategy has a considerable impact on cloud computing efficiency. The ineffec-tiveness of the VMP approach has a major negative impact on the CDC.Virtualization facilitated VM migration has met the ever-increasing demands of dynamic workload by transferring VMs inside CDC. Many resource management goals, including power efficiency, load balancing, fault tolerance, and system maintenance, are aided VM placement. As a result, VMP needs to assess characteristics that may impact placement performance and energy efficiency. Most past research has concentrated solely on reducing energy consumption while ignoring SLA (service level agreement) breaches, enhancing the resource usage of PMs, and ignoring the over-commitment issue. MOM-VMP To propose a multiobjective Mayfly VMP algorithm (MOM-VMP) meta-heuristic optimization algorithm with a massive CDC with different and multi-dimensional resources to handle these issues. A multi-objective dynamic VMP strategy is employed to reduce resource wastage, overcom-mitment ratio, migration time, SLA violation and energy consumption at the same time. This paper presents a dynamic multi-objective VMP in CDC based on overcommitment resource allocation to influence VM-PM mapping. We validated our method of conducting a performance evaluation study using the CloudSim tool. The experimental findings show that the suggested study decreases energy consumption, makespan, SLA violations, and PM overloading while enhancing resource utilization.
The Musical Turn in Biosemiotics: An Expressivist Model of Communication
Authors: Slayton Matthew , Hendlin Yogi 
Published: October 2022

Abstract
Human music and language are two systems of communication and expression that, while historically considered to overlap, have become increasingly divergent in their approach and study. Music and language almost certainly co-evolved and emerged from the same semiotic field, and this relationship as well as co-origin are actively researched and debated. For the sake of evaluating the semiotic content of zoomusicology, we investigate music from a ‘bottom-up’ biosemiotic functionalist account considering iconic, indexical, and symbolic forms of meaning not in a hierarchy but according to their effects on agents. Such an approach avoids overintellectualizing the representational aspects of music, and instead inverts, as it were, the traditional hierarchy of semiotic categories to produce illocutionary effects. Understanding aesthetics and action not as a priori separate but rather fundamentally co-arising elements of the same events, the focus of musicality again returns to interpretation and how semiosis precipitates expression.
A novel cuproptosis-related gene signature for the prediction of liver cancer prognosis identified DLAT is a potential therapeutic target
Authors: Xu Dong , Yang Fei , Chen Yang , Zhu Hong , Sun Haijian , Shen Tong , Zhu Yongkang , Zhou Guowei , Chen Dexuan , Yang Xiaojun , Lin Kai , Xia Cunbing 
Published: October 2022

Abstract
Background and Purpose: The liver cancer (LC) is a highly malignant tumor of the digestive system with a poor prognosis. Cuproptosis is a new type of regulated cell death that has been found by researchers. The expression of cuproptosis-related genes in LC and their relevance to prognosis, on the other hand, remain unknown. This study aimed to explore a gene signature to predict the liver cancer prognosis and identified the vital gene.
Experimental approach: The expression patterns of RNA and related clinical data of 371 LC patients were obtained based on The Cancer Genome Atlas (TCGA). Differentially expressed genes (DEGs) were acquired by comparing tumors with adjacent normal samples. Genes displaying significant association with OS were screened through univariate Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) algorithm. All cases were classified into the validation or training group to validate the constructed gene signature. We conducted real-time polymerase chain reaction (PCR) and assays for transwell invasion, CCK-8, and colony formation to determine the biological roles of DLAT. Key Results: The differential expression of twelve cuproptosis regulators in LC and normal liver tissues was discovered in this investigation. DEGs can be used to distinguish between two forms of LC. Cuproptosis-related genes were evaluated for survival predictive significance using the Cancer Genome Atlas (TCGA) cohort. A 3-gene signature based on least absolute shrinkage and selection operator (LASSO) Cox regression was used to categorize an LC patient cohort from the TCGA into low- and high-risk categories. Patients in the low-risk group had a considerably higher likelihood of surviving (P = 0.05) than those in the high-risk group. When paired with clinical parameters, risk score was an independent predictor in predicting the OS of patients with LC.
Conclusions & Implications: Cuproptosis-related genes thus play an important role in tumor formation and can be used to predict the prognosis of LC patients. DLAT has the best prognostic value and can be a therapeutic target for liver cancer.
The Political Economy of Ensar-Muhacir Discourse: The Involving of Syrians in Working Life in Turkey
Authors: DOĞANOĞLU Mustafa 
Published: October 2022

Büyük göç dalgalarının oluşması halinde hem göç eden nüfusun hem de göç edilen yörenin farklı açılardan etkilenmesi kaçınılmazdır. Göçmenlerin kalıcı olmaya yüz tutması halinde ise daha uzun vadeli etkilenmelerin oluşması kaçınılmazdır. Bu, uyum ve çatışma dikatomisinin, bir olgu olarak göçe içkin olmasının dolaysız sonucudur. Bu nedenle –doğal olarak- göç ve karşılaşma meselesini konu edinen çalışmalar, büyük ölçüde uyum-çatışma meselesiyle ve bu uyum-çatışma meselesinin nasıl yönetildiğiyle ilgili olagelmiştir. Yönetim biçimi, başka bir deyişle siyaset tekniği (ya da kamu politikası), söz konusu çatışma-uyum meselesinin nasıl boyut alacağı ve nasıl bir seyir izleyeceği üzerinde büyük etkiye sahiptir. Zira siyaset tekniği, toplumsal pratiği örgütlemek gibi bir işlevle yüklüdür.
Bilindiği gibi 2011 yılında Suriye iç savaşının başlamasıyla beraber Suriye’den Türkiye’ye doğru yoğun bir göç dalgası gerçekleşmiştir. Birkaç yıl devam eden bu göç dalgaları karşısında Türkiye, savaştan kaçan insanların, ülkeye girişi bağlamında açık-kapı politikası izlemiştir. Ensar-muhacir söylemi, başından itibaren bu açık-kapı politikasının meşrulaştırıcı söylemi olmuştur. Fakat savaşın uzaması ve üzerinden 11 yıl geçmiş olmasına rağmen hâlâ belirsizliğini koruması göçün yönetiminin, göçmenlerin durumunun en temel ve en yakıcı sorunlardan biri halini almasıyla neticelenmiştir. Buradan hareketle bu çalışma, söz konusu toplumsal pratikle siyaset tekniği arasındaki ilişkiye yoğunlaşmaktadır.
Karriertudatosság és perzisztencia a felsőoktatási hallgatók körében
Authors: Mohácsi Márta , Fényes Hajnalka 
Published: October 2022

A karriermenedzsment fontos szegmense, hogy az egyének (jelen esetben az egyetemi hallgatók) mennyire karriertudatosak. Tanulmányunkban az emberi tőke elméletre építve vizsgáljuk a felsőoktatási hallgatók továbbtanulási motivációit és a tanulmányok befejezése melletti elkötelezettségüket. Az elméleti részben a karrier, a karriertudatosság és a perzisztencia fogalmát határoljuk körül a szakirodalmak alapján, valamint röviden kitérünk az emberi tőke modell lényegére is. Hipotézisünk szerint a karriertudatos hallgatók az emberi tőke modell jóslatát (a diplomával szerezhető jól jövedelmező állás, könnyebb elhelyezkedés és elismert foglalkozás szerzése) veszik elsősorban figyelembe a továbbtanulás során, illetve emellett elkötelezettebbek tanulmányaik befejezése mellett, és úgy gondolják, hogy tanulmányaik hasznosak lesznek számukra a karrierjük során. Az empirikus részben a karriertudatosságot főkomponens elemzéssel vizsgáljuk számos változó bevonásával, és a képzett mutató(k) értékeit összevetjük a hallgató neme, társadalmi háttere, a képzés területe, szintje és finanszírozási formája szerint. Az adatok egy nagymintás hallgatói adatbázisból származnak, a kutatás Magyarország keleti régiójának felsőoktatási intézményeiben folyt.
Thermodynamics of the Association of Aminoglycoside Antibiotics with Human Angiogenin
Authors: Dasgupta Swagata , Panda Atashi , Halder Krishna , Debnath Debkumar , De Soumya 
Published: October 2022

Background:It is crucial for the body to maintain a firm balance between the inducers and inhibitors of angiogenesis, the process of proliferation of blood vessels from pre-existing ones. Human angiogenin (hAng) is a potent inducer of angiogenesis and the search for inhibitors has become a vital research area. Aminoglycosides are linked ring systems consisting of amino sugars and an aminocyclitol ring and are in use in clinical practices for a long time. These compounds have found clinical uses as antibacterial agents that inhibit bacterial protein synthesis.Objective:Gentamycin C1, Kanamycin A, Neomycin B, Paromomycin I, and Streptomycin A are commonly used aminoglycoside antibiotics that have been used for the present study. Among these, Neomycin has reported inhibitory activity against angiogenin-induced angiogenesis on the chicken chorioallantoic membrane. This study focuses on the thermodynamic parameters involved in the interactions of these antibiotics with hAng.Main Findings:Anti-ribonucleolytic effect of the antibiotics was observed qualitatively using an agarose gel-based assay, which shows that Neomycin exhibits the most efficient inhibition of hAng. Fluorescence quenching studies at different temperatures, using Stern-Volmer and van’t Hoff equations provide information about the thermodynamics of binding, which furthermore highlights the higher binding constant of Neomycin. Docking studies provide an insight into the participation of specific amino acid residues with the aminoglycoside antibiotics. It was observed that the antibiotics preferably interact with the nuclear translocation site, except Streptomycin, which interacts with the ribonucleolytic site of the protein with low affinity.
A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by
using Bioenhancer and Nanoparticulate Drug Delivery System
Authors: Kumar Mohit , Kumar Devesh , Kumar Sumant , Kumar Akshay , Mandal Uttam Kumar 
Published: October 2022

Background:
Intravenous route of drug administration has maximum bioavailability, which shows
100% of the drug reaches blood circulation, whereas the oral administration of drugs, are readily undergoing
pre-systemic metabolism, which means the poor bioavailability of the drug and limited amount of drug reaches
the target site.

Introduction:
Bioenhancers are substances having medicinal entities which enhance the bioavailability and efficacy
of the active constituents of drugs. The enhanced bioavailability of drugs may lead to dose reduction,
which may further reduce the cost and undesired side effects associated with the drugs.

Methods:
The solid lipid nanoparticles (SLNs) loaded with ketoprofen made from carnauba wax and beeswax.
It was discovered that when the drug-loaded SLNs were mixed with egg-lecithin and Tween-80, as well
as when the total surfactant concentration was increased, the average particle size of the drug-loaded SLNs
decreased.

Result:
The drug-loaded nanoparticles, when given in combination with bio-enhancers such as piperine and
quercetin, enhanced the drug's effectiveness. The Area Under Curve (AUC) was increased when the drug was
coupled with bio-enhancers. Based on the findings, it can be concluded that piperine and quercetin when used
with drug-loaded nanoparticles improve their therapeutic effectiveness.

Conclusion:
Bioenhancers are crucial to amplifying the bioavailability of many synthetic drugs. These attributes
are useful to reduce the dose of drugs and increase the therapeutic efficacy of drugs with poor bioavailability.
Synthetic Routes to Quinoline-Based Derivatives having Potential Anti-Bacterial and
Anti-Fungal Properties
Authors: Sharma Shivangi , Singh Shivendra 
Published: October 2022

Abstract:
Quinoline and its derivatives are part of several natural products. Many of them are
active pharmacophores and show enormous biological activities. Owing to their usefulness in
drug discovery, we have discussed the plethora of quinoline derivatives showing particularly
antibacterial and antifungal activities in this article. Depending upon substitution on the quinoline
core, change of functionalities at different positions and change in chain length; unique
biological properties are associated with such derivatives of quinolines and in this article, we
have delineated the antibacterial and antifungal activities of such activities in detail. In most of
the cases, it has been found that substitution at the 5-position leads to enhanced bioactivities. In
most cases, 5-halo/5-amino/5-aryl and heteroaryl/5-carbonyl/5-amido show promising antibacterial
and antifungal activities. Furthermore, the synthetic aspects of several quinoline derivatives
showing antibacterial and antifungal activities are also discussed in this article.
Pathomechanism of the IVDs Degeneration and the Role of Neurotrophic
Factors and Concentration of Selected Elements in Genesis of Low Back
Pain
Authors: Staszkiewicz Rafał , Gładysz Dorian , Gralewski Marcin , Garczarek Michał , Gadzieliński Marcin , Grabarek Beniamin Oskar 
Published: October 2022

:
Degenerative disc disease of the lumbosacral spine is a very common medical problem.
An episode of sciatica occurs at least once in the life of 60-90% of the human population.

:
A phenomenon that is closely related to the process of lowering the pH of the extracellular matrix
degenerating the intervertebral disc (IVD) is the precipitation of calcium salts, especially pyrophosphate
dehydrate and hydroxyapatite.

:
In such an altered environment of the IVD, we can observe an increased influx of monocytes, macrophages,
T-lymphocytes, as well as non-immunocompetent cells, which are a source of cytokines,
e.g., tumor necrosis alpha (TNF-α), interleukin- (IL-1β, IL-8). The above-mentioned mediators of an
inflammatory condition contribute to an increase in the expression of Brain-Derived Neurotrophic
Factor (BDNF) and Glial cell Derived Neurotrophic Factor (GDNF) in mast cells and chondrocytes,
as well as to the descending transport of these mediators along the nerve endings.

:
In the process of degeneration of the IVD as a result of repeated and even slight injuries, there is
damage to the connections of the endplate of the vertebral bodies with the IVD, which results in an
impairment of the penetration of nutritional substances and water into the disc. As a consequence,
there is an overexpression of the brain-derived neurotrophic factor GDNF, as well as neuromodulin
(GAP-43) in the mast cells and chondrocytes of the IVDs, while descending transport of these mediators
along the nerve fibers is also observed.
Motivational Design for Web-Based Instruction in Health Professions Education: Protocol for a Systematic Review and Directed Content Analysis
Authors: Gavarkovs Adam , Kusurkar Rashmi A , Kulasegaram Kulamakan , Crukley Jeff , Miller Erin , Anderson Melanie , Brydges Ryan 
Published: October 2022

BackgroundWeb-based instruction plays an essential role in health professions education (HPE) by facilitating learners’ interactions with educational content, teachers, peers, and patients when they would not be feasible in person. Within the unsupervised settings where web-based instruction is often delivered, learners must effectively self-regulate their learning to be successful. Effective self-regulation places heavy demands on learners’ motivation, so effective web-based instruction must be designed to instigate and maintain learners’ motivation to learn. Models of motivational design integrate theories of motivation with design strategies intended to create the conditions for motivated engagement. Teachers can use such models to develop their procedural and conceptual knowledge in ways that help them design motivating instruction in messy real-world contexts. Studies such as randomized controlled trials (RCTs) and other quasi-experimental designs that compare different motivational design strategies play a critical role in advancing models of motivational design. Synthesizing the evidence from those studies can identify effective strategies and help teachers and researchers understand the mechanisms governing why strategies work, for whom, and under what circumstances.ObjectiveThe planned review aims to analyze how studies comparing motivational design strategies for web-based instruction in HPE support and advance models of motivational design by (1) controlling for established risks to internal validity, (2) leveraging authentic educational contexts to afford ecological validity, (3) drawing on established theories of motivation, (4) investigating a wide breadth of motivational constructs, and (5) analyzing mediators and moderators of strategy effects.MethodsThe planned review will use database searching, registry searching, and hand searching to identify studies comparing motivational design strategies for web-based instruction, delivered to learners in HPE. Studies will be considered from 1990 onward. Two team members will independently screen studies and extract data from the included studies. During extraction, we will record information on the design characteristics of the studies, the theories of motivation they are informed by, the motivational constructs they target, and the mediators and moderators they consider.ResultsWe have executed our database and registry searches and have begun screening titles and abstracts.ConclusionsBy appraising the characteristics of studies that have focused on the motivational design of web-based instruction in HPE, the planned review will produce recommendations that will ensure impactful programs of future research in this crucial educational space.Trial RegistrationPROSPERO CRD42022359521; https://tinyurl.com/57chuzf6International Registered Report Identifier (IRRID)DERR1-10.2196/42681
Analisis Penggunaan Sistem Informasi Laboratorium Pada Pegawai Balai Besar Teknik Kesehatan Lingkungan Dan Pengendalian Penyakit (BBTKLPP) Yogyakarta
Authors: Hendrizal David 
Published: October 2022

Latar Belakang: Sistem Informasi Laboratorium BBTKLPP Yogyakarta merupakan suatu usaha untuk menyajikan informasi yang akurat, tepat waktu dan sesuai kebutuhan guna menunjang proses fungsi-fungsi manajemen dan pengambilan keputusan dalam memberikan pelayanan di BBTKL Yogyakarta. Dengan penerapan Sistem Informasi ini diharapkan nantinya dapat meningkatkan mutu khususnya pelayanan laboratorium, dan menunjang tugas pokok dan fungsi BBTKLPP Yogyakarta. Selain itu, penerapan sistem informasi ini juga diharapkan dapat meningkatkan motivasi pegawai dalam melaksanakan tugas sehari-hari, pelayanan dan penyebaran informasi kepada publik menjadi lebih cepat dan hasil pengolahan data dari sistem informasi ini dapat menjadi dasar dalam pengambilan keputusan. Tahapan kritis dalam penerapan teknologi informasi adalah saat kondisi dimana kehadiran sistem tersebut diterima atau ditolak oleh calon pengguna. Penghambat proses adaptasi ini terjadi disebabkan adanya kecenderungan perbedaan persepsi mengenai manfaat dan kemudahan dari teknologi informasi baru untuk digunakan. TAM merupakan sebuah konsep yang dianggap paling baik dalam menjelaskan perilaku user terhadap sistem teknologi informasi baru.Tujuan Penelitian: Untuk mengetahui faktor-faktor yang mempengaruhi pegawai Balai Besar Teknik Kesehatan Lingkungan dan Pemberantasan Penyakit (BBTKLPP) Yogyakarta dalam menggunakan Sistem Informasi Laboratorium.Metode Penelitian: Jenis penelitian ini adalah penelitian kuantitatif menggunakan Metode survei dengan rancangan cross-sectional. Sampel penelitian berjumlah 33 responden yang merupakan total dari keseluruhan populasi. Teknik analisis data yang digunakan adalah teknik analisis SEM-PLS dengan model TAM menggunakan software SmartPLS versi 3.2.6.Hasil: Berdasarkan outer model diketahui bahwa konstruk telah memenuhi validitas dan reliabilitas, sedangkan hasil iner model didapatkan nilai path-coeficient dan p-values yang menjadi dasar pengambilan kesimpulan. Dari hasil pengujian dan analisia didapatkan beberapa hipotesis yang tidak berpengaruh secara signifikan yaitu variable keterkaitan pekerjaan terhadap manfaat/kegunaan, terminology dan desain layar terhadap kemudahan, dan kondisi fasilitas pendukung terhadap penggunaan sistem. Sedangkan variable yang berpangaruh secara signifikan adalah kualitas keluaran, result demonstrability, dan persepsi kemudahan terhadap manfaat/kegunaan, complexity terhadap persepsi kemudahan, persepsi manfaat/kegunaan terhadap ketertarikan untuk menggunakan, persepsi kemudahan terhadap ketertarikan untuk menggunakan dan ketertarikan untuk menggunakan terhadap penggunaan system.Kesimpulan: Tidak semua variabel yang diteliti berpengaruh secara signifikan terhadap penggunaan Sistem Informasi Laboratorium (SIL) pada pegawai BBTKL Yogyakarta. Dari 11 variabel yang diteliti, diketahui 7 variabel memiliki pengaruh yang signifikan terhadap penggunaan.