bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model
Authors: Olaniyi Kehinde S. , Bashir Al-amin M. , Areloegbe Stephanie E. , Sabinari Isaiah W. , Akintayo Christopher O. , Oniyide Adesola A. , Aturamu Ayodeji 
Published: July 2022

Background
Polycystic ovarian syndrome (PCOS) is pathogenically characterized with hyperandrogenism and metabolic alterations, which often result in ovarian changes and infertility in women of reproductive age. Epigenetic changes have been linked to the development of PCOS. However, the involvement of epigenetic regulator, histone deacetylase (HDAC) in PCOS-driven ovarian dysfunction is not clear. Howbeit, the present study hypothesized that acetate, an HDAC inhibitor (HDACi) would protect against ovarian dysfunction in experimentally induced PCOS.

Materials and methods
Female Wistar rats weighing 120–150 g were randomly divided into four groups (n = 6). The groups received vehicle, sodium acetate (200 mg/kg), letrozole (1 mg/kg) and letrozole with acetate by oral gavage respectively. The administrations were done daily for 21 days.

Results
The rat model of PCOS had increased body weight and ovarian weight, 1-hr postload glucose and plasma insulin, testosterone and LH/FSH ratio as well as reduced insulin sensitivity and plasma 17-β estradiol and sex hormone binding globulin. This model of PCOS in addition showed a significant increase in plasma and ovarian triglyceride, total cholesterol, TNF-α and HDAC, and ovarian malondialdehyde as well as a significant reduction in ovarian glutathione peroxidase/reduced glutathione and NrF2 with the histology of ovarian tissues showing disrupted morphology with significant increase in the number of degenerated follicles compared with control group. These alterations were however attenuated when treated with HDACi, acetate.

Conclusion
Altogether, the present results suggest that acetate protects ovarian function with evidence of normal growing follicles and enhanced circulating 17-β estradiol by inhibition of HDAC.
ترجمات ودراسات أعمال الكاتب الصيني لو شون في مصر / Translations and Studies of the Works of Chinese Writer Lu Xun in Egypt
Authors: Fahmy Hussein Hassanein 
Published: July 2022

Abstract
The Chinese writer Lu Xun (1881-1936) is considered one of the most important writers in the history of Chinese literature. His works have been translated over the years into many foreign languages, including Arabic. In addition to translating his works, foreign researchers have presented many studies on his thought and literature, and Lu Xun’s studies and translations into Arabic played an important role in introducing Lu Xun’s creativity and thought and even modern Chinese literature in general, and these translations had a clear impact on the influence of a number of Egyptian and Arab writers on literature, like Egyptian writer Abdel Ghaffar Makawy and Syrian writer Olfat Al-Idlibi. With the development witnessed by the specialization of Chinese language and literature in Egypt, Lu Xun studies in Egypt saw a remarkable progress. A number of Egyptian researchers presented Chinese-language studies on Lu Xun literature in addition to studies that are presented from a comparative point of view between Lu Xun and a number of Egyptian writers.
الصورة الأدبية لنجيب محفوظ في الصين / Naguib Mahfouz’s Literary Image in China
Authors: Shuhong Ding 
Published: July 2022

Abstract
Adopting a translation criticism approach of descriptive analysis, the thesis, from a cross-cultural perspective, combs through the development about translation, introduction and the acceptance of Naguib Mahfouz by the Chinese before and after he won the Nobel Prize in Literature. After a synchronic and diachronic study of the attitudes and ways of acceptance for Mahfouz during different periods, the thesis unravels the process in which Mahfouz’s literary image has developed from a simple “teller of social problems” to a sophisticated “writer of the world.” Besides, the thesis explores the Chinese scholars’ cultural filtering and value orientation towards Mahfouz, oriental writer and Nobel laureate, as well as Mahfouz’s influence and constraints of China’s present cultural and linguistic contexts.
التعاون الصيني العربي في مجال الفضاء: الفرص والتحديات / Sino-Arab Space Cooperation: Opportunities and Challenges
Authors: Berro Tamara 
Published: July 2022

Abstract
In recent years, space has become a new area of cooperation between China and Arab countries. This cooperation, based on mutual respect, openness, equality and mutual benefit, is of great importance due to its role in developing and strengthening relations between the two sides and pushing them forward. Despite the progress witnessed by the Chinese-Arab relations in the field of space sciences, there are challenges facing space cooperation between the two sides, relating to the conditions of some Arab countries that have suffered wars, and political, economic and social crises, in addition to the relationship that links the countries of the region with some major countries. This research sheds light on the space program of China and shows how this country has made great progress in the field of space sciences, it also includes the space program of Arabic countries, some of which have recently witnessed a remarkable development in space sciences, trying to catch up with the more developed countries in this field. This research also discusses the cooperation between China and Arab countries, stresses the importance of this cooperation, and puts forward the challenges that could impede the process of space cooperation.
The system’s genetics of depression and its somatic and mental comorbidities
Authors: Kalinichenko Liubov S. , Kornhuber Johannes , Müller Christian P. 
Published: July 2022

Abstract
Depression is a common mood disorder characterised by high comorbidity with other mental and somatic diseases. New studies reveal a shared genetic base for mental core symptoms and somatic comorbidities. Functional analyses showed multiple brain–body pathways involved. This may help considering new therapeutic approaches for depression as a system’s disorder.
Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach
Authors: Cicia Alessandra , Nociti Viviana , Bianco Assunta , De Fino Chiara , Carlomagno Vincenzo , Mirabella Massimiliano , Lucchini Matteo 
Published: July 2022

Abstract
Neurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history. The peculiar spinal magnetic resonance imaging finding characterized by a posterior and central canal subpial contrast enhancement, the so-called “trident sign,” together with chest computed tomography scan and lymph node biopsy led to the diagnosis of sarcoidosis. We also discuss the main differential diagnoses of LETM and therapeutic options for sarcoidosis-related myelitis.
IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion
Authors: Wu Pei-Li , Zhu Jing-Wen , Zeng Cheng , Li Xin , Xue Qing , Yang Hui-Xia 
Published: July 2022

In brief
Insufficient trophoblast invasion at the maternal–fetal interface contributes to abortion-prone pregnancy. Our study shows that decreased levels of IGFBP7 in unexplained recurrent spontaneous abortion (URSA) trophoblast cells inhibit MMP2 and Slug expression as well as trophoblast invasion, suggesting that IGFBP7 should be considered a potential therapeutic protein target in URSA.

Abstract
Insufficient trophoblast invasion at the maternal–fetal interface contributes to abortion-prone pregnancy. Cyclosporine A (CsA) can exert therapeutic effects on URSA by promoting trophoblast invasion. A previous study showed decreased expression of insulin-like growth factor-binding protein 7 (IGFBP7) in the sera of recurrent spontaneous abortion patients. However, the role of IGFBP7 in URSA remains unknown. The aim of this study was to determine whether IGFBP7 modulates trophoblast invasion in URSA and the underlying molecular mechanisms. We found that IGFBP7 was expressed at lower levels in villous specimens from URSA patients. Manipulating IGFBP7 expression significantly affected the MMP2 and Slug expression in HTR-8/SVneo cells as well as trophoblast invasion in vitro. Inactivation of IGF-1R by IGFBP7 was observed, and IGF-1R inhibition increased the IGFBP7-induced MMP2 and Slug expression in HTR-8/SVneo cells. Moreover, the level of c-Jun was significantly upregulated in the URSA group. Silencing IGFBP7 increased the binding of downstream c-Jun to the MMP2 and Slug promoter regions in HTR-8/SVneo cells, thus suppressing transcription. In addition, increased expression of IGFBP7 in HTR-8/SVneo cells was observed upon CsA treatment. Knockdown of IGFBP7 inhibited the CsA-enhanced MMP2 and Slug expression in HTR-8/SVneo cells. Our results suggest that in normal pregnancy, IGFBP7 induces MMP2 and Slug expression via the IGF-1R-mediated c-Jun signaling pathway, thereby promoting trophoblast invasion. IGFBP7 depletion in URSA inhibits MMP2 and Slug expression as well as trophoblast invasion. Moreover, IGFBP7 participates in CsA-induced trophoblast invasion, suggesting that IGFBP7 is a potential therapeutic target for URSA.
Namen und Macht in Mosambik
Authors: Jahn Susanne 
Published: July 2022

Während sich auf vielen virtuell zugänglichen Karten Mosambiks noch zahlreiche Toponyme aus der Kolonialzeit finden lassen, die seit Erlangung der Eigenstaatlichkeit 1975 eigentlich längst (wieder) einen afrikanischen Namen tragen, wird die Kritik im Land an der unauthentischen Schreibung autochthoner Ortsnamen lauter. Hinter dieser steht der Gedanke, dass nur durch ein konsequentes ,desaportuguesamento‘ (Ngunga 2021) der Namenslandschaft Mosambiks im Einklang mit den jeweiligen Lokalsprachen der Bantugruppe die endgültige Befreiung vom (portugiesischen) Kolonialismus erreicht und die eigene nationale Identität gestärkt werden könne. Allerdings steht dabei auch eine Einrichtung wie das 2009 geschaffene Instituto Nacional de Nomes Geográficos Moçambicanos (INGEMO) u. a. vor dem Problem, inwieweit die angestrebte Harmonisierung der Ortsnamen angesichts der Tatsache, dass die ursprüngliche Bedeutung der Namen in den ihnen zugrunde liegenden Sprachen oft kaum noch rekonstruierbar sind, ihrerseits mehr als symbolischer Natur sein und etwa historisch-linguistischen Kriterien standhalten kann.
ÉLITES, IMPUESTOS Y DESIGUALDAD SOCIAL EN LA COSTA RICA NEOLIBERAL
Authors: Arias Chavarría Esteban 
Published: July 2022

Este trabajo parte de las premisas y categorías de la sociología fiscal para analizar la relación entre impuestos, desigualdad social, conflictividad fiscal y élites empresariales. La metodología se basa en la comparación de tres coyunturas fiscales entre los años 2000-2018, así como la recopilación de información estadística relevante. Se indagan tres coyunturas fiscales y se observa de cerca la relación tributaria entre el Estado fiscal y las élites empresariales. Esto permite descubrir los factores macro-sociológicos detrás del régimen fiscal costarricense en el contexto neoliberal.
NATURALEZA DE LA POLÍTICA MIGRATORIA Y LA INFLUENCIA DEL ‘SIEMPRE PRESENTE’ CONTEXTO
Authors: Rivera María José 
Published: July 2022

El objetivo de este artículo es ofrecer una alternativa de reflexión teórica sobre la naturaleza político-filosófica de las políticas migratorias. La metodología consistió en un estudio de caso del proceso migratorio Ecuador-España (1997-2014). Se encontró que las políticas migratorias en fenómenos Sur-Norte están definidas por factores altamente contextuales que afirman asimetrías de poderes entre Estados, tanto Sur-Norte como Norte-Norte. La naturaleza de las políticas migratorias no responde al nivel micro, pero el migrante y su familia crean estrategias de ajuste y adaptación.
SİLDENAFİL SİTRAT VE DEKSPANTENOLÜN YARA İYİLEŞMESİ ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI: DENEYSEL ÇALIŞMA
Authors: HAKSEVEN Musluh , KAPAN Murat , ALABALIK Ulas , AVŞAR Gökhan 
Published: July 2022

Amaç
Yara iyileşmesi cerrahide yüksek morbiditeye neden
olabilen ciddi bir problemdir. Yara iyileşmesini hızlandırmak,
nekrozu veya iskemiyi önlemek için değişik
farmakolojik ajanlar çalışılmış ve halen yaygın olarak
çalışılmaya devam etmektedir. Yara iyileşmesinde
klinik pratikte topikal dekspantenolün geniş kulanım
alanları mevcuttur. Topikal dekspantenol hem yara
bakımında hem de dermatolojik hastalıkların tedavisinde
kullanılmaktadır. Bu çalışmamızda, ratlarda
oluşturulan deneysel yara modelinde lokal sildenafil
sitrat ve topikal dekspantenol uygulamalarının etkilerinin
karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem
Çalışmada 200–250 gram arasında değişen 30 Adet
Wistar Albino dişi rat kullanıldı. Hayvanlar üç gruba
ayrıldı. Deney hayvanlarının anestezisini takiben sırt
orta kesimlerine 2 cm uzunluğunda tam kat kalınlıkta
deri defekti oluşturuldu. Yara pansumanında tüm hayvanların
yaraları steril % 0.9 NaCl solüsyonu ile yıkandıktan
sonra kontrol grubu olduğu gibi bırakılırken,
irigasyon sonrası 2. gruba %5’lik dekspantenol krem,
3. gruba % 10’luk sildenafil krem uygulandı. Ratlarda
yara boyutları 3., 5., 7., 10., 14. ve 21. günlerde ölçülerek
kaydedildi ve 21. gün tüm ratların sırt kısımlarından
insizyon hattını içerecek şekilde tam kat deri
çıkarılarak histolojik incelemeye alındı.
Bulgular
Tüm gruplara genel olarak bakıldığında günlere göre
yara boyutlarındaki küçülme ve histopatolojik bulgular
açısından istatiksel olarak anlamlı fark saptanmadı.
Sonuç
Sildenafil sitratın yara boyutunda önemli bir azalmaya
yol açtığı için yara iyileşmesi için topikal bir krem olarak
kullanılabileceğine inanıyoruz.
PLURİPOTENT KÖK HÜCRELERDEN SİNİR HÜCRELERİNE FARKLILAŞTIRMA YÖNTEMLERİ
Authors: KURUŞ Meltem , ERGİN Kemal , ÇETİNKAYA Rahmi 
Published: July 2022

İnsan embriyonik kök hücreleri, embriyoların erken
blastokist evresindeki iç hücre kütlesinden türetilen
hücrelerdir. Pluripotent özellikte olan bu hücreler, uygun
koşullar altında fonksiyonel nöronlara ve farklı
tipte sinir hücrelerine farklılaştırılabilmektedir. Ancak
bu alandaki en büyük zorluklardan biri, yenilenebilir,
kültürü kolay, nöral soylara bağlı nöral prekürsör
hücre popülasyonu oluşturmaktır. Bu nedenle, insan
embriyonik kök hücrelerini prekürsör hücrelere en
uygun şekilde farklılaştırmak, bunların kendi kendini
yenileyen bir popülasyon olarak devam etmesi ve
farklı bölgelerdeki sinir hücre tiplerini saf bir popülasyon
şeklinde üretmek için kritik öneme sahiptir. Hücre
sinyalleri ve bunlarla ilişkili moleküller de bu olaylarda
önemli bir rol oynamaktadır. Nöral prekürsör hücrelerinin
üretilmesi için kök hücre biyolojisinin ve nöral
hücrelere farklılaşmada rol oynayan önemli yolakların
daha iyi anlaşılması gerekmektedir. Bu derlemede
kök hücrelerden nöral hücrelere farklılaştırma yöntemlerine
ve bu süreçte önemli olan sinyal yolaklarına
ve moleküllere odaklanılmaktadır.
Effect of Homogenization Pressure on Bacterial Cellulose Membrane Characteristic Made from Pineapple Peel Waste
Authors: Muhajir Muhamad , Suryanto Heru , Pradana Yanuar Rohmat Aji , Yanuhar Uun 
Published: July 2022

Many studies were conducted to maintain the environment by reducing the waste, especially pineapple peel waste. This study aims to explore the effect of various pressure of the homogenization process on bacterial cellulose membrane surface morphology and structure produced using extract of pineapple peel waste. The methods include the preparation of pellicle samples from the product of the fermentation process of Acetobacter xylinum using a medium from the extract of pineapple peel waste. Bacterial cellulose pellicles were crushed using a blender. Mashed bacterial cellulose pellicle then homogenized in High-Pressure Homogenizer with pressure variation of 0 bar, 150 bar, 300 bar, 450 bar, dan 600 bar then cast into a mold. The bacterial cellulose solutions were dried in an oven at 60°C for 8 hours. The dried bacterial cellulose membrane was analyzed using XRD for the structure and SEM analysis for the morphology. The results indicate that the crystalline properties of BCM were shifted after being treated by various pressure processing in a High-Pressure Homogenizer. It was found that the High-Pressure Homogenizer with higher pressure reduced the peak intensity, decreased crystalline index from 87% to 70%, and decreased the degree of crystalline from 88% to 77% without changing the cellulose structure. The higher pressure of the homogenization process causes the porosity of the membrane to be decreased.
Sinergisme Komunitas dalam Penyelenggaraan Pendidikan di Tengah Pandemi
Authors: Fathurrahman Fathurrahman , Al Faruq M. Saunan 
Published: July 2022

Abstract: The purpose of this research is to learn about community participation in the proses of education in Lamongan Regency. The data was collected through a descriptive qualitative approach and using Focus Group Discussion (FGD) as technique. Discussions conducted together with the literacy, education and social communities resulted in the findings that: (1) several activities carried out in the delivery of education during the pandemic were in the form of persuasion as well as activities based on the results of an analysis of the environmental conditions (grass roots problem), and (2) synergy between communities is able to contribute in the form of thoughts and actions as a learning solution carried out in the family and community environment. Abstrak: Tujuan dari penelitian ini adalah untuk mempelajari tentang peran serta komunitas dalam penyelenggaraan pendidikan di Kabupaten Lamongan. Pengumpulan data dilakukan melalui pendekatan kualitatif deskriptif dan menggunakan teknik wawancara dalam Focus Group Discussion (FGD). Diskusi yang dilakukan bersama dengan komunitas literasi, pendidikan dan sosial menghasilkan temuan bahwa: (1) beberapa kegiatan yang telah dilakukan dalam penyelenggaraan pendidikan selama pandemi berupa ajakan (persuasive) maupun kegiatan yang didasarkan pada hasil analisis kondisi lingkungan sekitar (grass roots problem), dan (2) sinergitas antar komunitas mampu memberikan sumbangsih berupa pemikiran dan tindakan sebagai solusi pembelajaran yang dilakukan dalam lingkungan keluarga dan masyarakat.
Pengembangan Media Teori Pendidikan Kewarganegaraan Liberal Berbasis Teknologi bagi Perguruan Tinggi di Masa Pandemi Covid-19
Authors: Mahanani Putri , Sutarno Sutarno , Muchtar Muchtar , Cholifah Puri Selfi 
Published: July 2022

Abstract: The theory of citizenship education is one of the main materials that must be understood by the next generation of the nation. One of the theories of civic education is the theory of liberal citizenship education. Based on the results of the initial interviews conducted, so far the learning media for civic education theory is still very limited. Therefore, it is necessary to develop technology-based learning media so that students can learn optimally even during the Covid-19 pandemic. This study aims to produce valid and interesting learning media for liberal citizenship education theory materials for college students. The research method used is the 4D model. Data collection techniques using observation techniques and questionnaires. The data analysis technique used quantitative descriptive techniques in the form of percentages and qualitative descriptive techniques in the form of exposure to generalizations from the results of the experiments carried out. The results showed that the learning media for liberal citizenship theory developed was valid and interesting. The results of media validation are 97.5 percent with a very valid category. The results of material expert validation are 91.67 percent with a very valid category. Meanwhile, the developed media has an attractive percentage of 89.44 percent of students. Abstrak: Teori Pendidikan kewarganegaraan merupakan salah satu materi utama yang harus dipahami generasi penerus bangsa. Teori pendidikan kewarganegaraan salah satunya yaitu teori pendidikan kewarganegaraan liberal. Berdasarkan hasil wawancara awal yang dilakukan, selama ini media pembelajaran materi teori pendidikan kewarganegaraan masih sangat terbatas. Oleh karenanya perlu untuk dikembangkan media pembelajaran berbasis teknologi agar mahasiswa bisa belajar maksimal meskipun di masa pandemi Covid-19. Penelitian ini bertujuan untuk menghasilkan media pembelajaran materi teori pendidikan kewarganegaraan liberal yang valid dan menarik bagi mahasiswa di perguruan tinggi. Metode penelitian yang digunakan yaitu model 4D. Teknik pengumpulan data menggunakan teknik observasi dan angket. Teknik analisis data menggunakan teknik deskriptif kuantitatif berupa persentase dan teknik deskriptif kualitatif berupa paparan generalisasi dari hasil uji coba yang dilakukan. Hasil penelitian menunjukkan bahwa media pembelajaran materi teori kewarganegaraan liberal yang dikembangkan telah valid dan menarik. Hasil validasi media sebesar 97,5 persen dengan kategori sangat valid. Hasil validasi ahli materi sebesar 91,67 persen dengan kategori sangat valid. Sementara itu media yang dikembangkan memiliki persentase menarik sebesar 89,44 persen dari mahasiswa.
PEMBUATAN KANTONG KAIN “TOTE BAG” SEBAGAI PENGGANTI KANTONG PLASTIK PADA PEMUDA WIRAUSAHA BLITAR
Authors: Farida Nurul , Widoretno Sri , Yuliastuti Eko 
Published: July 2022

Abstrak: Tujuan dari Pengabdian kepada Masyarakat dalam bentuk pelatihan membuat kantong belanja kain tote bag ini merupakan salah satu jalan untuk menekan banyaknya limbah plastik dan mendukung peraturan pemerintah dalam pengurangan penggunaan plastik. Peraturan tersebut membawa dampak yang positif bagi para pemuda wirausaha di Blitar atau Formusa untk membuat tas belanja tote bag yang ramah dengan alam dan terbuat dari kain. Tote bag adalah tas jinjing yang terbuat dari kain kanvas yang biasa digunakan sebagai tempat bawaan saat belanja, bawa buku bahkan anak sekolah dan para remaja sekarang banyak yang menggunakan tote bag, ini dikarenakan tote bag mudah dibawa, multifungsi, simple, elegan dan disukai oleh semua kalangan. Metode kegiatan membuat tote bag diawali dengan FGD. Melalui FGD ini dihasilkan pemuda di Formusa tidak bisa membuat sendiri sehingga membutuhkan waktu yang lama dan harga jual yang mahal. Kegiatan yang kedua adalah pembuatan tote bag dari persiapan bahan sampai produk jadi. Berdasarkan hasil kegiatan pembuatan kantong belanja kain tote bag peserta mendapatkan banyak ide-ide kreatif untuk mengembangkan dan berinovasi dalam membuat tote bag kearah yang lebih bagus lagi sesuai dengan selera dan kebutuhan konsumen.Abstract: The goal of Community Service in the form of training to make shopping bags for cloth tote bags is one way to reduce the amount of plastic waste and support government regulations on reducing plastic use. This regulation has a positive impact on young entrepreneurs in Blitar or Formusa to make shopping tote bags that are friendly to nature and made of cloth. A tote bag is a tote bag made of canvas fabric which is commonly used as a place to carry when shopping, bring books and even school children and many teenagers now use tote bags, this is because they are easy to carry, multifunctional, simple, elegant and liked by all circles. The method of making tote bags begins with an FGD. Through this FGD, it was produced that youth in Formusa could not make their own, so it took a long time and an expensive selling price. The second activity is making tote bags from material preparation to finished products. Based on the results of the activity of making tote bag shopping bags, the participants got lots of creative ideas to develop and innovate in making tote bags that are even better according to the tastes and needs of consumers.