bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphisms in exon 11 of the mptl-1 gene and monepantel resistance in Haemonchus contortus
Authors: Niciura Simone Cristina Méo , Okino Cintia Hiromi , Nucci Alessandra da Silva , Junior Wilson Malagó , Benavides Magda Vieira , Esteves Sergio Novita , Chagas Ana Carolina de Souza 
Published: September 2022

Abstract
Because chemical treatments are the main strategy to control gastrointestinal nematodes in sheep, molecular tests may constitute an excellent tool for the early detection of the emergence of resistance-related mutations. Thus, a polymerase chain reaction (PCR)-based genotyping assay followed by polyacrylamide gel electrophoresis (PAGE) was developed to detect polymorphisms in exon 11 of the acetylcholine receptor monepantel-1 gene (mptl-1) that were previously associated with monepantel resistance through a genome-wide study in Haemonchus contortus. DNA samples recovered from individual and pooled third-stage larvae from two susceptible field-derived isolates and five (three in vivo-derived and two field-derived) resistant populations were used. New polymorphisms, including a 6-bp deletion and a 3-bp insertion, were detected in resistant individuals. These indels, confirmed using sequencing of cloned PCR products, are predicted to result in amino acid changes in transmembrane domain 2 (TMD2) of the MPTL-1 protein. The two susceptible isolates showed only the presence of the wild-type allele (100%), whereas lower frequencies of the wild-type allele were detected in monepantel-resistant populations (11.1 to 66.7%). These findings report new polymorphisms in the mptl-1 gene, validate the results obtained through genomic mapping for monepantel resistance, and provide a PCR-based assay to genotype indels located in exon 11 of mptl-1 in H. contortus.
First detection of the Monkeypox virus using wastewater-based surveillance in Miami-Dade County
Authors: Sharkey Mark E , Babler Kristina M , Amirali Ayaaz , Grills George S , Kumar Naresh , Laine Jennifer , Lamar Walter E , Mason Christopher E. , Reding Brian D , Schurer Stephan , Shukla Bhavarth , Stevenson Mario , Vidovic Dusica , Solo-Gabriele Helena 
Published: September 2022

Abstract

This is a short communication so no abstract is included.
Child With Intra Cardiac Masses and Multiple Seizure Types. Rhabdomyoma, Tuberous Sclerosis and Possible Lennox-Gastaut Syndrome – A Rare Case Report
Authors: mahaseth Aditya , thaoa Lekhjung 
Published: August 2022

Abstract
Rhabdomyoma are the most common benign cardiac tumors. These are tumors with favorable prognosis because they frequently do not cause symptoms and they often regress in numbers and size. Due to frequent association with tuberous sclerosis complex and the resulting neurological impairment, the prognosis can be unfavorable (1). Here we report a case of a 7 months old boy who was diagnosed as cardiac rhabdomyoma during fetal life by fetal echocardiography and later went on to develop seizures as a part of tuberous sclerosis complex at 6 months of age. This report also highlights the difficulties in obtaining a diagnosis and practicing the latest evidence based treatment in low income underdeveloped country like nepal especially in patients belonging to the lower socioeconomic class due to financial shortages and lack of resources.
The Impact of CBN Monetary Policy on the Survival SMEs in Nigeria
Authors: Ogundipe Michael Oluwasegun 
Published: August 2022

Abstract
The purpose of this study was to determine how the CBN's monetary policies affect Nigerian SMEs' ability to survive. To investigate the data properties, a number of tests were run, including the unit-root test, and descriptive statistics. The explanatory variables and the dependent variable were tested for the presence of time-varying volatility and leptokurtosis using descriptive statistics. The relationship between the variables over the long and short terms was further examined using the Augmented Dickey Fuller (ADF) unit root test. Co-integration testing was done to confirm the outcome of the unit root test and to determine whether there was a long-term relationship between the variables. The findings indicate that whereas lending interest rates are negatively correlated with SME growth, money supply, commercial bank loans and advances, and bank reserves are positively correlated with SME growth. The study came to the conclusion that monetary policy is crucial to the success of SMEs in Nigeria. The consequence is that for SMEs to survive in Nigeria, the interaction of these factors is crucial.
Genotypic Correlates of Resistance to the HIV-1 Strand Transfer Integrase Inhibitor Cabotegravir
Authors: Rhee Soo-Yon , Parkin Neil , Harrigan P. Richard , Holmes Susan , Shafer Robert W. 
Published: September 2022

Abstract

Introduction: Cabotegravir (CAB) is an integrase strand transfer inhibitor (INSTI) formulated as a long-acting injectable drug approved for pre-exposure prophylaxis and use with a long acting rilpivirine formulation for maintenance therapy in patients with virological suppression. However, there has been no comprehensive review of the genetic mechanisms of CAB resistance. Methods: Studies reporting the selection of drug resistance mutations (DRMs) by CAB and the results of in vitro CAB susceptibility testing were reviewed. The impact of integrase mutations on CAB susceptibility was assessed using regularized regression analysis. Results: The most commonly selected mutations in the 24 persons developing virological failure while receiving CAB included Q148R (n=15), N155H (n=7), and E138K (n=5). T97A, G118R, G140A/R/S, and R263K each developed in 1-2 persons. With the exception of T97A, G118R, and G140A/R, these DRMs were also selected in vitro while G140R was selected in the SIV macaque model. Although these DRMs are similar to those occurring in persons receiving the related INSTI dolutegravir, Q148R was more likely to occur with CAB while G118R and R263K were more likely to occur with dolutegravir. Regularized regression analysis identified 15 DRMs significantly associated with reduced CAB susceptibility including seven primary DRMs which reduced susceptibility on their own including G118R, F121C, Q148H/K/R, N155H, and R263K, and eight accessory DRMs including M50I, L74F/M, T97A, E138K, and G140A/C/S. Isolates with Q148H/K/R in combination with L74M, E138A/K, G140A/S, and N155H often had >10-fold reduced CAB susceptibility. M50I, L74M, and T97A are polymorphic mutations that alone did not appear to increase the risk of virological failure in persons receiving a CAB-containing regimen. Conclusions: Careful patient screening is required to prevent CAB from being used during active virus replication. Close virological monitoring is required to minimize CAB exposure to active replication to prevent the emergence of DRMs associated with cross-resistance to other INSTIs.
Nagroda im. Profesora Mieczysława Gogacza (2007 – 2021)
Authors: Rejewska Julia 
Published: August 2022

Sympozjum Tomistyczne, połączone z wręczeniem Nagród im. Profesora Mieczysława Gogacza, organizowane jest przez Katedrę Historii Filozofii Instytutu Filozofii UKSW w Warszawie oraz Naukowe Towarzystwo Tomistyczne. Sympozjum jest okazją do uhonorowania najlepszych prac magisterskich, które, jak zapisano w Regulaminie Nagrody, „wpisują się w badanie myśli Św. Tomasza z Akwinu i promowanie filozofii tomistycznej w Polsce, a także nawiązują do dorobku naukowego Profesora Mieczysława Gogacza”. Podczas sympozjum laureaci nie tylko otrzymują nagrody, lecz także wygłaszają referaty, przedstawiając najistotniejsze zagadnienia ze swoich badań szerokiemu gronu odbiorców. Laureatami Nagrody zostali dotąd absolwenci kilku uczelni z całej Polski.
---------------------
Zgłoszono: 03/12/2021. Zrecenzowano: 22/01/2022. Zaakceptowano do publikacji: 08/04/2022.
Renal Effects of Empagliflozin in Patients with Type 2 Diabetes
Mellitus
Authors: Yaribeygi Habib , Maleki Mina , Sathyapalan Thozhukat , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: August 2022

Abstract:
Type 2 diabetes mellitus (T2DM) is one of the main causes of mortality and
morbidity worldwide. It leads to various long-term complications such as diabetic
nephropathy. Diabetes nephropathy is the leading cause of renal failure in patients with
chronic kidney diseases undergoing hemodialysis. Hence preventing the development and
progression of diabetic nephropathy is one of the main goals in the management of patients
with type 2 diabetes. Sodium-glucose cotransporter 2 inhibitors of empagliflozin is
a potent anti-hyperglycemic agents. In addition, it has been shown to have some pharmacologic
potentials to provide renoprotective effects in patients with T2DM. In the current
study, we review the available clinical data on the potential renoprotective effects of this
drug from a mechanistic and molecular viewpoint.
Challenges in Mesenchymal Stromal Cell-based Therapies
Authors: Kavianpour Maria , da Silva Meirelles Lindolfo , Ahmadbeigi Naser 
Published: August 2022

Abstract:
Over 50 years have passed since discovering mesenchymal stromal cells (MSCs). Initially,
despite gaps in the knowledge of the identity of these cells, their therapeutic aspects were recognized.
Consequently, MSCs became candidates for treating a wide range of diseases. However, the therapeutic
effects of MSCs are not stable in the long term, and there are inconsistent data on their clinical efficacy.
Even though more than 1000 MSC-based clinical trials have been registered, and the safety of MSCbased
cell therapies has been proven, data on the clinical efficacy of MSCs have not been enough to warrant
FDA approval for clinical treatment and marketing purposes. The available information on MSCs
still contains some controversies, perhaps owing to little progress in understanding their in vivo identity.
MSCs have been used for therapeutic purposes despite poor knowledge of their in vivo origin or functions.
Hence, perhaps we need to go back to the basics of MSCs and spend more time understanding the
biology of these cells. An improved understanding of MSCs' location and function within tissues may
improve their therapeutic efficacy and, consequently, their establishment as a cell therapy product.
Comparison of the Sedative Effect of Ketamine, Magnesium Sulfate, and Propofol in Patients Undergoing Upper Gastrointestinal Endoscopy: Double-Blinded Randomized Clinical Trial
Authors: Shafiee Hamed , Riahipour Farahnaz , Hormati Ahmad , Ahmadpour Sajjad , Habibi Mohammad Amin , Vahedian Mostafa , Aminnejad Reza , Saeidi Mohammad 
Published: August 2022

Background:Endoscopy provides valuable diagnostic information and intervention therapies for gastroenterologists. Therefore, various drugs have been used to induce sedation in patients undergoing endoscopy, whereas none have been considered preferred by endoscopists. In the current study, we decided to use the combination of magnesium sulfate, ketamine, and their synergistic effects for creating partial analgesia to increase the satisfaction of endoscopists and patients.Methods:This study is a Double-Blind Randomized Clinical Trial that investigates the sedative effect of ketamine, magnesium sulfate, and propofol in endoscopy. Patients were selected from individuals over 12 years old and with American Society of Anesthesia (ASA) physical status I or II. The study was performed on 210 patients classified as ASA (I have no underlying disease) or II (with underlying controlled disease). The whole group was relieved of pain through sedation according to Ramsay criteria, satisfaction with the operation, duration, recovery, nausea and vomiting, hypotension, and decreased oxygen saturation were compared.Results:A total of 155 patients were enrolled in our study, including 51 patients (midazolam and propofol), 55 patients (midazolam and ketamine), and 49 patients (midazolam and ketamine and magnesium). The results showed that preoperative heart rate, intraoperative systolic blood pressure, intraoperative diastolic blood pressure, postoperative heart rate, postoperative systolic blood pressure, and postoperative heart rate were significantly different between the groups.Conclusion:The satisfaction of the endoscopic was achieved to a great extent, mainly in the group receiving midazolam and propofol and in the group receiving midazolam and ketamine. In most cases, the satisfaction of the endoscopic was acceptable, and the low satisfaction of the endoscopic was more in the group receiving midazolam. Ketamine and magnesium were observed. The two compounds midazolam-ketamine, and midazolam-propofol, have a more favorable effect than the combination of midazolam, ketamine, and magnesium.
How Do Investor and Auditor Materiality Judgments Compare?
Authors: DeZoort F. Todd , Holt Travis P. , Stanley Jonathan D. 
Published: August 2022

SUMMARY
Materiality remains a challenging concept for auditors to implement in practice. The challenges underlying auditor materiality assessments are compounded by the fact that materiality is typically defined from the investor’s (rather than the auditor’s) perspective. Despite this investor orientation, there is little empirical evidence about investors’ materiality judgments, specific quantitative and qualitative factors underlying their judgments, and how their judgments compare to auditors who implement materiality in practice. This article summarizes a recent study by DeZoort, Holt, and Stanley (2019) that addresses this problem by modeling sophisticated and unsophisticated investors’ materiality judgments in a policy-capturing study, using experienced auditors as a benchmark. Results indicate significant differences in materiality judgments, judgment consensus, and cue utilization among the three participant groups. Findings also reveal between-group differences in self-reported quantitative materiality thresholds, judgment self-insight, as well as judgment confidence. We conclude the article with a discussion of the practical implications surrounding these findings.
Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity: The EFIGRO Project
Authors: Cadenas-Sanchez Cristina , Idoate Fernando , Cabeza Rafael , Villanueva Arantxa , Rodríguez-Vigil Beatriz , Medrano María , Osés Maddi , Ortega Francisco B. , Ruiz Jonatan R. , Labayen Idoia 
Published: August 2022

OBJECTIVE
In adults, there is evidence that improvement of metabolic-associated fatty liver disease (MAFLD) depends on the reduction of myosteatosis. In children, in whom the prevalence of MAFLD is alarming, this muscle-liver crosstalk has not been tested. Therefore, we aimed to explore whether the effects of a multicomponent intervention on hepatic fat is mediated by changes in intermuscular abdominal adipose tissue (IMAAT) in children with overweight/obesity.

RESEARCH DESIGN AND METHODS
A total of 116 children with overweight/obesity were allocated to a 22-week family-based lifestyle and psychoeducational intervention (control group, n = 57) or the same intervention plus supervised exercise (exercise group, n = 59). Hepatic fat percentage and IMAAT were acquired by MRI at baseline and at the end of the intervention.

RESULTS
Changes in IMAAT explained 20.7% of the improvements in hepatic steatosis (P &lt; 0.05). Only children who meaningfully reduced their IMAAT (i.e., responders) had improved hepatic steatosis at the end of the intervention (within-group analysis: responders −20% [P = 0.005] vs. nonresponders −1.5% [P = 0.803]). Between-group analysis showed greater reductions in favor of IMAAT responders compared with nonresponders (18.3% vs. 0.6%, P = 0.018), regardless of overall abdominal fat loss.

CONCLUSIONS
The reduction of IMAAT plays a relevant role in the improvement of hepatic steatosis after a multicomponent intervention in children with overweight/obesity. Indeed, only children who achieved a meaningful reduction in IMAAT at the end of the intervention had a reduced percentage of hepatic fat independent of abdominal fat loss. Our findings suggest that abdominal muscle fat infiltration could be a therapeutic target for the treatment of MAFLD in childhood.
Prevalence of Diabetes among Adults in Agbani South East, Nigeria: A Population Based Study
Authors: Edeh Anthony J. , Eze Balantine U. , Ohayi Samuel R. , Anekpo Chijioke C. , Okoloagu Nkiruka N. , Aliozo Chukwuebuka C. , Soronnadi Clara N. 
Published: August 2022

Despite the rising prevalence of diabetes mellitus in Nigeria, population based studies are scarce. This situation is worse in rural areas where the people are typically poor, not very educated and lack good hospitals. We aimed to determine the prevalence of diabetes mellitus among rural dwellers in Agbani, a semi-urban municipality in South East Nigeria. This was a preliminary, observational, cross-sectional investigation in which 400 adults were recruited using the 5 autonomous communities that make up Agbani as clusters. We randomly selected the initial 80 consenting adults from each village. Blood glucose levels were measured using a glucometer. Data obtained were analyzed using SPSS. There were 382 adults studied. There were 170 males and 212 females. The mean age was 59.37 ±15.90 years. Mean Blood Sugar was 135.69±85.94 mg/dl. The prevalence rate for hyperglycemia in this study was 20.14% or 201 persons per 1,000 rural population. There was no statistical difference between the mean blood sugar of males and females and no significant correlation between age and blood sugar.
The Use of E-Training and Development as Principals Administrative Task on Secondary School Teachers’ Job Performance
Authors: Anho Joseph Efe 
Published: September 2022

Electronic training and development is the conscious efforts to influence, training, and development of teachers using electronic media to improve and increase their knowledge, skills, and abilities to perform their scheduled roles effectively in the school system. The design of the study is an expost-facto design using the correlational descriptive survey method. The population comprised 15356 from which 659 principals and teachers were sampled using the stratified random sampling technique. Two selfconstructed/developed questionnaires and a checklist were used. The first is tagged “Questionnaire on Principals’ use of E-Training and Development as Administrative Task for Secondary Schools Teachers’ Job Performance” (QPEPFDPSP). The checklist was on forms of available information resources in schools while the second was a “questionnaire on teachers' work performance scale”. The questionnaire was based on the adapted four (4) points scoring scale of strongly agree; = 4 points, agree = 3 points; disagree = 2 points and strongly disagree = 1 point. The 2 questionnaires were subjected to a validity test while the reliability test was done using the Pearson Product Moment Correlation ‘r’ and the coefficient ‘r’ of 0.85 was obtained. To guide the study, four research questions were raised and one hypothesis was formulated and tested at a 0.05 level of significance. The findings among others include: The findings indicated that principals and teachers have not embraced the utilization of electronic resources in administration, and teaching and that the important ICT resources (hardware and software) were not available. Also, there is a significant relationship between the use of electronic training and development by secondary school principals and teachers' job performance. Therefore this paper recommended that: Principals as school administrators have to be disposed to make sure they continuously sponsor and or involve their teachers in continuous e-training and development. Secondary school administration/principals and teachers should be made to undergo courses on the use of electronic resources in administration and in teaching. Consequently, school proprietors, government, and individuals should assist schools to make available some basic electronic/computer hard and soft wares for school.
Gender, Family, Work and School: Demographic and Other Deterrents to Adult Participation
Authors: Malhotra Naveen 
Published: September 2022

Using the results of a larger study utilizing Cross's (1981) three-part formulation of the 24-item barrier scale devised by Carp, Peterson, and Roelfs (1974), this paper presents demographic differences in the perception of barriers to adult higher education. The scale items were tested with a population of prospective students at public institutions of higher learning, and the resulting six factors were compared against demographic categories of gender, marital status, a number of dependent children, income, and hours of work per week.
The Relationship between the COVID-19 Pandemic and Early Pregnancy Abortions
Authors: Arican Cigdem Dicle 
Published: September 2022

Aims: The present study aims to find the relationship between the COVID-19 pandemic and early pregnancy abortions.

Methods: The abortion materials observed in the endometrial curettage cases between March 11 and November 30 during the 2020 pandemic period were compared with the those were observed at the same time in 2019. The placentas of COVID-19 positive patients and those of early abortion in the previous year were compared. Furthermore, the relationship between the blood type and covid 19 related abortions were examined. This retrospective study applies various statistical tests to analyze the relationship between COVID-19 and abortions.

Findings: The data collected from the samples in 2019 and 2020 were analyzed statistically. Significant differences were found between the causes of miscarriages in 2019 and 2020.

Conclusion: The results indicated that there were significant vascular changes in the placentas of pregnant women among the cases of early abortions due to COVID-19 during the pandemic period. In addition, a significant relation was found between ARH+ blood type and COVID-19 on miscarriages. The results suggest that COVID-19 is one of the main causes of early pregnancy abortions.
Redefining the Quality of Online Courses: From A Smiley Test To A Seven-Star Rating
Authors: Osman Mohamed El Tahir 
Published: September 2022

The past two decades have witnessed an exponential increase of both blended and fully online courses in higher education. Nevertheless, despite the invested efforts in defining and examining quality issues concerning online courses, there seems to be an equal growth in the challenges as well as the boundaries for defining the quality of online courses. According to a large body of literature, it appears that the most common instruments for gauging quality are course evaluations and surveys from the perspectives of instructors, learners, and administrators based on their perceptions, and experiences. In light of the rapidly changing needs of the new generation of “digital” learners, this study aims to redefine the quality of online courses from a comprehensive perspective that would expand the quality standards beyond pedagogical issues to include the hidden aspects of quality such as the instructional design, web design, facilitation and coaching, course presentation, learning experience, as well as service experiences. The study employs a mixed-method research design including, a descriptive-analytic methodology of both quantitative and qualitative approaches, where a triangulated set of data were collected from a diverse sample of Instructional designers, SMEs, and students enrolled in a fully online course at Sultan Qaboos University. The outcomes of this study could be used as a blueprint for designing online courses that respond to learners’ diverse needs.