bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction Models for Future High-Need High-Cost Healthcare Use: a Systematic Review
Authors: de Ruijter Ursula W. , Kaplan Z. L. Rana , Bramer Wichor M. , Eijkenaar Frank , Nieboer Daan , van der Heide Agnes , Lingsma Hester F. , Bax Willem A. 
Published: January 2022

Abstract
Background
In an effort to improve both quality of care and cost-effectiveness, various care-management programmes have been developed for high-need high-cost (HNHC) patients. Early identification of patients at risk of becoming HNHC (i.e. case finding) is crucial to a programme’s success. We aim to systematically identify prediction models predicting future HNHC healthcare use in adults, to describe their predictive performance and to assess their applicability.

Methods
Ovid MEDLINE® All, EMBASE, CINAHL, Web of Science and Google Scholar were systematically searched from inception through January 31, 2021. Risk of bias and methodological quality assessment was performed through the Prediction model Risk Of Bias Assessment Tool (PROBAST).

Results
Of 5890 studies, 60 studies met inclusion criteria. Within these studies, 313 unique models were presented using a median development cohort size of 20,248 patients (IQR 5601–174,242). Predictors were derived from a combination of data sources, most often claims data (n = 37; 62%) and patient survey data (n = 29; 48%). Most studies (n = 36; 60%) estimated patients’ risk to become part of some top percentage of the cost distribution (top-1–20%) within a mean time horizon of 16 months (range 12–60). Five studies (8%) predicted HNHC persistence over multiple years. Model validation was performed in 45 studies (76%). Model performance in terms of both calibration and discrimination was reported in 14 studies (23%). Overall risk of bias was rated as ‘high’ in 40 studies (67%), mostly due to a ‘high’ risk of bias in the subdomain ‘Analysis’ (n = 37; 62%).

Discussion
This is the first systematic review (PROSPERO CRD42020164734) of non-proprietary prognostic models predicting HNHC healthcare use. Meta-analysis was not possible due to heterogeneity. Most identified models estimated a patient’s risk to incur high healthcare expenditure during the subsequent year. However, case-finding strategies for HNHC care-management programmes are best informed by a model predicting HNHC persistence. Therefore, future studies should not only focus on validating and extending existing models, but also concentrate on clinical usefulness.
How Is Collective Identity Possible in Democracies? Political Integration and the Leitkultur Debate in Germany
Authors: Bein Simon 
Published: January 2022

AbstractThe quest for a common collective identity has become a challenge for modern democracy: Liberal demands for greater inclusion and individual freedom, aspirations for a strong and solidaric political community, as well as nationalist or right-wing populist calls for exclusion and a preservation of hegemonic national identities are creating tensions that cannot be overlooked. This article therefore formulates the central question of how collective identity can be possible in a liberal democracy. Based on a case study on Germany, it will therefore be examined whetherLeitkulturas a model of political integration can serve in generating a functional democratic collective identity. The necessary benchmarks guiding the analysis will be defined beforehand from a systems-theoretical perspective, balancing inclusion and exclusion within three crucial dimensions: normative basics, historic continuity, and affirmative bindings. The results show that a static definition of a GermanLeitkulturwould in the long run neither achieve functional inclusion nor be able to generate the necessary cohesion of a political community, especially regarding the second and third identity dimensions.
One Anastomosis Gastric Bypass Versus Long Biliopancreatic Limb Roux-en-Y Gastric Bypass
Authors: Ibrahim Mohamed Y. , Elshennawy Abdelmoneim S. , Wassef Arsany Talaat Saber , Salah Ayman , Hassan Ahmed M. , Mikhail Sameh 
Published: January 2022

Abstract
Background
Roux-en-Y gastric bypass (RYGB) is one of the most effective bariatric procedures. The study aimed to explore the value of lengthening the biliopancreatic limb (BPL) in RYGB compared to the outcome of one-anastomosis gastric bypass (OAGB).

Methods
This prospective study included morbidly obese patients divided into two groups. The RYGB group (n = 36) was subjected to long biliary limb Roux-en-Y gastric bypass (LPRYGB), and the OAGB Group (n = 36) had one anastomosis gastric bypass. During follow-up, weight, BMI, percentage of excess body weight loss (%EBWL), resolution of obesity-related comorbidities, and quality of life (QoL) were evaluated.

Results
There was no significant difference in weight and BMI after 3 and 6 months. At 12-month follow-up, weight loss was significantly higher in the OAGB group. After 12 months, the two groups showed significant improvement of comorbid conditions without significant difference between the two groups. The Qol was significantly higher in the LPRYGB group 3, 6, and 12 months after surgery compared to the OAGB group.

Conclusions
Extending the BPL length in RYGB to 150 cm is as effective as OAGB in remission of comorbidities, including diabetes. It was also equally effective in weight reduction in the short term. OAGB was more efficient in weight reduction and a significantly faster operation. LPRYGB showed a better QoL of life 1 year after surgery.

Graphical abstract
Reappraisal of Grading in Intestinal-Type Sinonasal Adenocarcinoma: Tumor Budding as an Independent Prognostic Parameter
Authors: Meerwein Christian M. , Brada Muriel D. , Soyka Michael B. , Holzmann David , Rupp Niels J. 
Published: January 2022

AbstractSince sinonasal intestinal-type adenocarcinomas (ITAC) show resemblance to colorectal adenocarcinomas, we aimed to investigate novel prognostic factors of outcome, with particular focus on the role of tumor budding (TB). Retrospective clinico-pathological single-institution study on consecutive ITAC patients between 1996 and 2020. Histopathological parameters including conventional subtypes and TB features (low, intermediate, high) were evaluated with the aid of pancytokeratin (AE1/AE3) immunohistochemical staining. Parameters were correlated to clinical data and outcome. A total of 31 ITAC patients were included. Overall, 19/31 patients (61.3%) presented with stage III/IV disease. Presence of lymph node or distant metastases was rare (1/31 patient, 3.2%). Treatment protocols consisted of tumor resection in 30/31 patients (96.8%) and primary radiochemotherapy in 1/31 patient (3.2%). Adjuvant radiation therapy was conducted in 20/30 surgically treated patients (66.7%). The 3- and 5-year overall survival (OS) was 83.9% and 78.3% and the 3- and 5-years disease-specific survival (DSS) 83.7% % and 78.5%, respectively. The presence of intermediate/high TB (defined as ≥ 5 buds) was associated with both, worse DSS (log rank p = 0.03) and OS (log rank p = 0.006). No patient with low TB revealed progressive disease or died of the disease. No association between TB and tumor stage or conventional tumor subtype was found. Tumor budding seems to be an independent prognostic factor of worse outcome in ITAC.
Which Large- and Medium-Sized Mammals Use Commercial Short-Rotation Coppice as Habitat?
Authors: Zitzmann Felix , Reich Michael 
Published: January 2022

AbstractWe surveyed occurrence and activity of large- and medium-sized mammals on six commercial mini-rotation short-rotation coppice (SRC) plantations in northern Germany by camera trapping in different seasons (winter, late summer). In total, eleven species (6–9 per site) were detected. This corresponds to the majority of mammal species occurring in the study region. Roe deer, wild boar and red fox were found across all sites. All other species were detected on fewer sites and some in only one of the seasons. Roe deer was the most active species both in terms of visit frequency (days with detection) and use intensity (detection numbers). With few exceptions on individual sites, all other species showed significantly lower activity. Number of detected species and activity of most of the species did not differ between seasons. Furthermore, there were no differences between near-edge and central areas of the crops with regard to the activity of the occurring species. Activity of individual species on different sites, however, differed considerably in some cases. Our results show that a wide range of mammal species are basically able to include SRC into their habitat utilisation. However, the sporadic use by most species indicates a rather limited current habitat value of the surveyed plantations. Options to increase the habitat value of SRC for mammals are suggested, but their effectiveness needs to be tested in future studies. Since the spatial and temporal scope of our study was limited and only SRC of a uniform age-class were considered, our results are not immediately applicable to other landscapes, seasons or types and management phases of SRC. Therefore, further research is required that considers these aspects as well as species-specific patterns of habitat selection in comparison to other habitat types.
Remarkably enhanced dielectric stability and energy storage properties in BNT—BST relaxor ceramics by A-site defect engineering for pulsed power applications
Authors: Li Zhipeng , Li Dong-Xu , Shen Zong-Yang , Zeng Xiaojun , Song Fusheng , Luo Wenqin , Wang Xingcai , Wang Zhumei , Li Yueming 
Published: January 2022

AbstractLead-free bulk ceramics for advanced pulsed power capacitors show relatively low recoverable energy storage density (Wrec) especially at low electric field condition. To address this challenge, we propose an A-site defect engineering to optimize the electric polarization behavior by disrupting the orderly arrangement of A-site ions, in which $${\rm{B}}{{\rm{a}}_{0.105}}{\rm{N}}{{\rm{a}}_{0.325}}{\rm{S}}{{\rm{r}}_{0.245 - 1.5x}}{_{0.5x}}{\rm{B}}{{\rm{i}}_{0.325 + x}}{\rm{Ti}}{{\rm{O}}_3}$$

Ba

0.105

Na

0.325

Sr

0.245
−
1.5
x

□

0.5
x

Bi

0.325
+
x

TiO
3

($${\rm{BN}}{{\rm{S}}_{0.245 - 1.5x}}{_{0.5x}}{{\rm{B}}_{0.325 + x}}{\rm{T}}$$

BNS

0.245
−
1.5
x

□

0.5
x

B

0.325
+
x

T
, x = 0, 0.02, 0.04, 0.06, and 0.08) lead-free ceramics are selected as the representative. The $${\rm{BN}}{{\rm{S}}_{0.245 - 1.5x}}{_{0.5x}}{{\rm{B}}_{0.325 + x}}{\rm{T}}$$

BNS

0.245
−
1.5
x

□

0.5
x

B

0.325
+
x

T
ceramics are prepared by using pressureless solid-state sintering and achieve large Wrec (1.8 J/cm3) at a low electric field (@110 kV/cm) when x = 0.06. The value of 1.8 J/cm3 is super high as compared to all other Wrec in lead-free bulk ceramics under a relatively low electric field (< 160 kV/cm). Furthermore, a high dielectric constant of 2930 within 15% fluctuation in a wide temperature range of 40–350 °C is also obtained in $${\rm{BN}}{{\rm{S}}_{0.245 - 1.5x}}{_{0.5x}}{{\rm{B}}_{0.325 + x}}{\rm{T}}$$

BNS

0.245
−
1.5
x

□

0.5
x

B

0.325
+
x

T
(x = 0.06) ceramics. The excellent performances can be attributed to the A-site defect engineering, which can reduce remnant polarization (Pr) and improve the thermal evolution of polar nanoregions (PNRs). This work confirms that the $${\rm{BN}}{{\rm{S}}_{0.245 - 1.5x}}{_{0.5x}}{{\rm{B}}_{0.325 + x}}{\rm{T}}$$

BNS

0.245
−
1.5
x

□

0.5
x

B

0.325
+
x

T
(x = 0.06) ceramics are desirable for advanced pulsed power capacitors, and will push the development of a series of Bi0.5Na0.5TiO3 (BNT)-based ceramics with high Wrec and high-temperature stability.
Novel 3D grid porous Li4Ti5O12 thick electrodes fabricated by 3D printing for high performance lithium-ion batteries
Authors: Liu Changyong , Qiu Yin , Liu Yanliang , Xu Kun , Zhao Ning , Lao Changshi , Shen Jun , Chen Zhangwei 
Published: January 2022

AbstractThree-dimensional (3D) grid porous electrodes introduce vertically aligned pores as a convenient path for the transport of lithium-ions (Li-ions), thereby reducing the total transport distance of Li-ions and improving the reaction kinetics. Although there have been other studies focusing on 3D electrodes fabricated by 3D printing, there still exists a gap between electrode design and their electrochemical performance. In this study, we try to bridge this gap through a comprehensive investigation on the effects of various electrode parameters including the electrode porosity, active material particle diameter, electrode electronic conductivity, electrode thickness, line width, and pore size on the electrochemical performance. Both numerical simulations and experimental investigations are conducted to systematically examine these effects. 3D grid porous Li4Ti5O12 (LTO) thick electrodes are fabricated by low temperature direct writing technology and the electrodes with the thickness of 1085 µm and areal mass loading of 39.44 mg·cm−2 are obtained. The electrodes display impressive electrochemical performance with the areal capacity of 5.88 mAh·cm−2@1.0 C, areal energy density of 28.95 J·cm−2@1.0 C, and areal power density of 8.04 mW·cm−2@1.0 C. This study can provide design guidelines for obtaining 3D grid porous electrodes with superior electrochemical performance.
Neurofilament light chain concentration in an aging population
Authors: Ladang Aurélie , Kovacs Stéphanie , Lengelé Laetitia , Locquet Médéa , Reginster Jean-Yves , Bruyère Olivier , Cavalier Etienne 
Published: January 2022

Abstract
Background
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies in the normal aging population are lacking. It is, therefore, urgent to identify influencing factors of NF-L concentration in the aging population.

Method
We assessed NF-L concentration in sera of a large cohort of 409 community-dwelling adults aged over 65 years. We studied the association between NF-L and various physiological factors but also with self-reported comorbidities or life-style habits.

Results
We showed that NF-L concentration in serum was tightly associated with cystatin C concentration (r = 0.501, p < 0.0001) and consequently, to the estimated glomerular filtration rate (eGFR) (r = − 0.492; p < 0.0001). Additionally, NF-L concentration was dependent on age and body mass index (BMI) but not sex. Among the self-reported comorbidities, subjects who reported neurological disorders, cardiovascular diseases or history of fracture had higher NF-L concentration in univariate analysis, whereas it was only the case for subjects who reported neurological disorders in the multivariate analysis. NF-L concentration was also increased when Mini-Mental State Examination (MMSE) was decreased (≤ 25 points) but not when geriatric depression score (GDS) was increased (> 5 points) in both univariate and multivariate analysis. Finally, we are providing reference ranges by age categories for subjects with or without altered renal function.

Conclusion
NF-L concentration in the aging population is not driven by the increasing number of comorbidities or depression. Yet, NF-L blood concentration is dependent on kidney function and NF-L interpretation in patients suffering from renal failure should be taken with caution.
Emergent Intraverbal and Reverse Intraverbal Behavior Following Listener Training in Children with Autism Spectrum Disorder
Authors: Almås Inger Karin , Smith Dean P. , Eldevik Sigmund , Eikeseth Svein 
Published: January 2022

AbstractWe evaluated whether intraverbal and reverse intraverbal behavior emerged following listener training in children with autism spectrum disorder (ASD). Six participants were each taught three sets of three “when?” questions in listener training. A multiple baseline design across behaviors (stimulus sets) was used to assess the effects of listener training. Results showed that intraverbal behavior emerged following listener training for five out of six participants. One participant received additional listener training and intraverbal training before intraverbal behavior emerged. Furthermore, reverse intraverbal responding occurred across all three sets of questions for three of the six participants. Establishing listener behavior may be a pathway for emergent intraverbal and reverse intraverbal responding in children with ASD. Future research could examine what skill repertoire may facilitate such transfer.
In-situ electrochemical modification of pre-intercalated vanadium bronze cathodes for aqueous zinc-ion batteries
Authors: Li Jianwei , Hong Ningyun , Luo Ningjing , Dong Haobo , Kang Liqun , Peng Zhengjun , Jia Guofeng , Chai Guoliang , Wang Min , He Guanjie 
Published: January 2022

AbstractVanadium bronzes have been well-demonstrated as promising cathode materials for aqueous zinc-ion batteries. However, conventional single-ion pre-intercalated V2O5 nearly reached its energy/power ceiling due to the nature of micro/electronic structures and unfavourable phase transition during Zn2+ storage processes. Here, a simple and universal in-situ anodic oxidation method of quasi-layered CaV4O9 in a tailored electrolyte was developed to introduce dual ions (Ca2+ and Zn2+) into bilayer δ-V2O5 frameworks forming crystallographic ultra-thin vanadium bronzes, Ca0.12Zn0.12V2O5·nH2O. The materials deliver transcendental maximum energy and power densities of 366 W h kg−1 (478 mA h g−1 @ 0.2 A g−1) and 6627 W kg−1 (245 mA h g−1 @ 10 A g−1), respectively, and the long cycling stability with a high specific capacity up to 205 mA h g−1 after 3000 cycles at 10 A g−1. The synergistic contributions of dual ions and Ca2+ electrolyte additives on battery performances were systematically investigated by multiple in-/ex-situ characterisations to reveal reversible structural/chemical evolutions and enhanced electrochemical kinetics, highlighting the significance of electrolyte-governed conversion reaction process. Through the computational approach, reinforced “pillar” effects, charge screening effects and regulated electronic structures derived from pre-intercalated dual ions were elucidated for contributing to boosted charge storage properties.
The Pleasures of Tranquillity
Authors: Voorhoeve Alex 
Published: January 2022

Abstract
Epicurus posited that the best life involves the greatest pleasures. He also held that it involves attaining tranquillity. Many commentators, including Ken Binmore, have expressed scepticism that these two claims are compatible. For, they argue, Epicurus’ tranquil life is so austere that it is hard to see how it could be maximally pleasurable. Here, I offer an Epicurean account of the pleasures of tranquillity. I also consider different ways of valuing lives from a hedonistic point of view. Benthamite hedonists value lives by the sum of pleasures minus the sum of pains, weighted by intensity and duration. Meanwhile, Binmore proposes that Epicurus valued lives by their worst episode. In contrast, I outline an Epicurean argument for why the best life is one in which a person attains tranquillity and tastes its pleasures until death.
Mapping of additive and epistatic QTLs linked to seed longevity in bread wheat (Triticum aestivum L.)
Authors: Arif Mian Abdur Rehman , Agacka-Mołdoch Monika , Qualset Calvin O. , Börner Andreas 
Published: January 2022

AbstractPlant genetic resources are stored and regenerated in > 1750 gene banks storing > 7,000,000 accessions. Since seeds are the primary storage units, research on seed longevity is of particular importance. Quantitative trait loci (QTL) analysis of 15 traits related to seed longevity and dormancy using 7584 high-quality SNPs recorded across 2 years and originated from five production years revealed a total of 46 additive QTLs. Exploration of the QTLs with epistatic effect resulted in the detection of 29 pairs of epistatic QTLs. To our information, this is only the second report of epistatic QTLs for seed longevity in bread wheat. We conclude that in addition to dense genetic maps, the epistatic interaction between loci should be considered to capture more variation which remained unnoticed in additive mapping.
Bacon causes cancer: Do consumers care?
Authors: He Xiaoyang , Lusk Jayson L. 
Published: January 2022

AbstractIn October 2015, the International Agency for Research on Cancer (IARC) released a report classifying processed meat as a type 1 carcinogen. The report prompted headlines and attracted immediate public attention, but the economic impacts remain unknown. In this paper, we investigate the impacts of the IARC report on selected processed meat prices and purchases using retail scanner data from US grocery stores. We compare changes in prices and sales of selected processed meat products to a constructed synthetic control group (using a convex combination of nonmeat food products). We find a significant decrease in bacon prices in the wake of the IARC report release, but we find no evidence of a sales reduction. We find no significant changes in price and sales for ham and sausage. The pattern of price and quantity changes are consistent with downward shifts in demand and outward shifts in supply for bacon and sausage following the release of the IARC report.
Vertical and Horizontal Networks and Export Performance in the Spanish Wine Industry
Authors: Ferrer Juan-Ramón , Abella-Garcés Silvia , Serrano Raúl 
Published: January 2022

AbstractWineries in the “old world” export almost 40% of their production. This study analyzes the influence of vertical and horizontal networks on export performance. We draw on a sample of 183 Spanish wineries and examine the main independent variables using a two-step Heckman model. We find positive effects of horizontal networks and—at a somewhat lower level—downstream vertical networks on export performance. (JEL Classifications: L66, M16, Q13)
“Hold infinity in the palm of your hand.” A functional description of time expressions through fingers based on Chinese Sign Language naturalistic data
Authors: Lin Hao , Gu Yan 
Published: January 2022

AbstractThis paper investigates the relationship between fingers and time representations in naturalistic Chinese Sign Language (CSL). Based on a CSL Corpus (Shanghai Variant, 2016–), we offer a thorough description of finger configurations for time expressions from 63 deaf signers, including three main types: digital, numeral incorporation, and points-to-fingers. The former two were further divided into vertical and horizontal fingers according to the orientation of fingertips. The results showed that there were interconnections between finger representations, numbers, ordering, and time in CSL. Vertical fingers were mainly used to quantify time units, whereas horizontal fingers were mostly used for sequencing or ordering events, and their forms could be influenced by Chinese number characters and the vertical writing direction. Furthermore, the use of points-to-fingers (e.g., pointing to the thumb, index, or little finger) formed temporal connectives in CSL and could be patterned to put a conversation in order. Additionally, CSL adopted similar linguistic forms in sequential time and adverbs of reason (e.g., cause and effect: events that happened earlier and events that happen later). Such a cause-and-effect relationship was a special type of temporal sequence. In conclusion, fingers are essential for time representation in CSL and their forms are biologically and culturally shaped.
The Attorney-General, politics and logistics – a fork in the road?
Authors: Hand James 
Published: January 2022

AbstractThe appointment of recent Attorney-Generals for England and Wales has occasioned much comment about their experience. This paper considers whether, following the transmogrification of the Lord Chancellorship over a decade ago, the backgrounds and activities of recent leaders of the Attorney-General's Office suggest the time is now right for similar changes to the Law Officers’ roles. In doing so, it presents a range of original data on aspects of the role and on characteristics of Attorney-Generals, which suggests that unless self-restraint is exercised (by the Prime Minister and the post-holders) we may ineluctably be on the path to reform.