bluuebunny/crossref_metadata_2025_split huggingface dataset:
liderazgo institucional y su incidencia en el clima laboral para la formación de la interdisciplinariedad en el colegio Vicente Rocafuerte.
Authors: Ferrin-Plaza Angel , Villacis-Zambrano Angelica 
Published: February 2022

El presente artículo de investigación tiene como finalidad presentar un estudio y análisis sobre la incidencia del liderazgo institucional que ocurre en el clima laboral de la Unidad Educativa Vicente Rocafuerte, enfocado en la formación de interdisciplinariedad entre los docentes que laboran en mencionada institución educativa, ubicada en la ciudad de Guayaquil.
Este artículo académico es de revisión teórica, es decir, se basa en la búsqueda de información de fuentes confiables, tales como, artículos de revista, libros, bases de datos, entre otros, aplicando metodologías que sugieren los académicos expertos en el ámbito de la investigación científica en concordancia con las variables de estudio.
Para la realización de esta investigación se utilizará el método analítico, mediante la recopilación de información como base teórica sobre la gestión educativa, el liderazgo en la cultura organizacional; así mismo, para realizar el análisis de la problemática se trabajará con el método hipotético-deductivo, empleando el proceso inductivo mediante la observación y deductivo a través de la generación de hipótesis y sus posibles resultados.
Finalmente, para alcanzar los objetivos de la investigación y dar solución a la problemática a través de la propuesta se identifica un modelo de liderazgo enmarcado en las buenas prácticas sociales, mismo que su comportamiento será analizado y estudiado desde un enfoque de observación directa, ya que comprenderá de realidades complejas y simbólicas, para obtener resultados que se asemejen a la realidad del entorno laboral en la unidad de estudio.
Redox-Hopping-Based Charge Transport Mediated by Ru(II)-Polypyridyl Species Immobilized in a Mesoporous Metal-Organic Framework
Authors: Duan Jiaxin , Goswami Subhadip , Hupp Joseph T. 
Published: February 2022

Electronic charge transport through crystalline metal-organic frameworks (MOFs) can be accomplished by site-to-site electron (or hole) hopping, provided that redox-active sites, such as easily reducible or oxidizable MOF linkers, are present. If the framework itself is redox-inert, solvent-assisted ligand incorporation of redox-active moieties can serve to enable hopping-based charge transport. Here we have studied the redox hopping process within Ru-bpy@NU-1008, where Ru-bpy is a carboxylate-functionalized derivative, i.e., a node-ligating derivative, of the well-known chromophore Ru(2,2′-bipyridine)32+, and NU-1008 is a redox-inert MOF featuring hierarchical porosity and csq topology. Chronoamperometry experiments with electrode-supported thin films of Ru-bpy@NU-1008 show that charge transport is feasible through portions of the MOF, with other portions being inaccessible. Possible confounding features are the undersized c-pores that cross-connect 1D mesoporous channels, as ingress and egress of charge-compensating anions is believed to accompany the net oxidation of Ru(II) to Ru(III) and the reduction of Ru(III) to Ru(II). Phenomenologically, transport through the electroactive portion of the films is diffusion-like, with the magnitude of the apparent diffusion coefficient being 6 × 10−12 cm2/s.
A Downscaling Intercomparison Study: The Representation of Slope- and Ridge-Scale Processes in Models of Different Complexity
Authors: Kruyt Bert , Mott Rebecca , Fiddes Joel , Gerber Franziska , Sharma Varun , Reynolds Dylan 
Published: February 2022

Spatially distributed meteorological information at the slope scale is relevant for many processes in complex terrain, yet information at this sub-km spatial resolution is difficult to obtain. While downscaling to kilometer resolutions is well described in literature, moving beyond the kilometer scale is not. In this work, we present a methodical comparison of three downscaling methods of varying complexity, that are used to downscale data from the Numerical Weather Prediction model COSMO-1 at 1.1 km horizontal resolution to 250 and 50 m over a domain of highly complex terrain in the Swiss Alps. We compare WRF, a dynamical atmospheric model; ICAR, a model of intermediate complexity; and TopoSCALE, an efficient topography-based downscaling scheme. Point-scale comparisons show similar results amongst all three models w.r.t. mean-error statistics, but underlying dynamics are different. Ridge-flow interactions show reasonable agreement between WRF and ICAR at 250 m model resolution. However, at 50 m resolution WRF is able to simulate complex flow patterns that ICAR cannot. Validation against Lidar data suggests that only WRF is able to capture preferential deposition of snow. Based on these findings and the significant reduction in computational costs, ICAR is a cost efficient alternative to WRF at the 250 m resolution. TopoScale performs very well in point-scale comparisons, but it is unclear if this can be attributed to the model itself or to the forcing data and the observations assimilated therein. Further study is required to quantify this effect.
Environment of the Early Pleistocene Banshan Paleolithic Site in the Nihewan Basin, North China
Authors: Yang Jiaxing , Zhang Zhen , Li Yuecong , Wang Fagang , Fan Baoshuo , She Zijing , Xie Hongli , Wang Siyu , Da Shuoqiang 
Published: February 2022

The Banshan archaeological site is one of the most important Early Pleistocene Paleolithic sites in the Nihewan Basin in North China. Based on analyses of pollen, grain size and charcoal of 56 samples from a sedimentary profile, we reconstructed the environment of the Banshan site before and after the interval of hominin activity (1.340–1.290 Ma). The results show that before the appearance of hominin activity (1.340–1.324 Ma), the climate of the region was initially cold and wet and then cold and dry. The regional vegetation was mainly Pinus and Picea forest in the earlier stage, and steppe dominated by arid-tolerant plants such as Artemisia and Chenopodiaceae in the later stage. During the period of hominin activity (1.324–1.318 Ma), the climate was warm and wet, the vegetation was mainly Pinus forest, and the site was a lakeside environment which would have provided resources such as food and water for hominins. During 1.318–1.310 Ma, the climate was warm and wet, the lake continued to expand and the lake level rose, which may have forced the hominins to migrate outside the area. During 1.310–1.290 Ma, the climate changed from warm and humid to cold and arid, accompanied by the change of the regional vegetation from forest to forest-grassland. Hominin activity at the Banshan site occurred during the interval of climate change from cold and dry to warm and wet, and it ended with the rise of the ancient lake level at Nihewan and the deterioration of the climate.
FAM46C as a Potential Marker for Pan-Cancer Prognosis and Predicting Immunotherapeutic Efficacy
Authors: Deng Jiehua , Xiao Wei , Wang Zheng 
Published: February 2022

Background:FAM46C is a common mutated gene in tumours. A comprehensive understanding of the relationship between FAM46C expression and pan-cancer can guide clinical prognosis and broaden the immunotherapeutic targets.Methods: Data from The Cancer Genome Atlas and Genotype-Tissue Expression (GTEx) databases were obtained, and gene expression of different tumour types and stages was analysed. Immunohistochemical analysis was performed to detect differences in the FAM46C protein levels in normal and cancerous tissues. The genetic variation of FAM46C was characterised using cBioPortal. The clinical prognostic value of FAM46C and the impact of FAM46C expression levels on the prognosis of patients with different types of cancer were assessed based on Kaplan–Meier and Cox regression analyses. Gene set enrichment analysis (GSEA) was used to analyse the pathways associated with FAM46C. Correlations between FAM46C expression levels and immune infiltration were assessed using the TIMER2 database and CIBERSORT algorithm, and correlations between FAM46C expression and the ESTIMATE, immune and stromal scores were analysed using the ESTIMATE algorithm. In addition, we also analysed the correlation between FAM46C expression and immune activation, suppression genes and immune chemokines.Results: The expression level of FAM46C was correlated with the prognosis of most tumours, and low expression levels often suggested a poor prognosis. FAM46C was positively correlated with the abundance of CD4+ T cells, CD8+ T cells and plasma B lymphocytes in the tumour microenvironment. FAM46C exhibited a strong correlation with immunomodulatory pathways, immunomodulatory factors and immune markers. In addition, high FAM46C expression correlated with tumour mutational burden in acute myeloid leukaemia and microsatellite instability in endometrial cancer.Conclusion: Our study suggests that FAM46C can be a potential prognostic marker for pan-cancer, is closely associated with immune regulation and may be an immune checkpoint to guide future clinical immunotherapy.
A Novel Combined Use of Dupilumab for Treatment of Aggressive Refractory Pemphigus Vulgaris Complicated With Pulmonary Tuberculosis: A Case Report and the RNA-seq Analysis
Authors: Chen Siji , Zhan Shaowei , Hua Chunting , Tang Yi , Cheng Hao 
Published: February 2022

BackgroundPemphigus vulgaris (PV) is a kind of IgG-mediated autoimmune blistering disease (AIBD) that is characterized by loss of keratinocyte adhesion in the epithelium of mucous membranes or skin. Recently, pemphigus vulgaris was thought to be associated with classical T helper 2 (TH2)-type cytokines such as interleukin‐4 (IL-4) and interleukin‐17 (IL-17) signaling pathway. A humanized monoclonal IgG4 antibody called dupilumab binds to the alpha subunit of the interleukin‐4 receptor (IL‐4Rα) and inhibits the signaling of IL-4 and interleukin‐13 (IL-13), which has been successfully applied for atopic dermatitis and asthma. Currently, the clinical trial evaluating dupilumab in bullous pemphigoid is ongoing.ObjectiveTo determine whether dupilumab may be of benefit in the aggressive refractory pemphigus vulgaris.MethodsWe report a 35-year old male with refractory pemphigus vulgaris and pulmonary tuberculosis who received treatment with dupilumab for 10 weeks. The mRNA expression of peripheral blood mononuclear cells (PBMCs) was analyzed by RNA sequencing (RNA-seq) which showed the gene expression changes after treatment.ResultsThe skin lesions of the patient improved in response to the combined use of dupilumab, moderate dose of glucocorticosteroids, and intravenous immune globulin (IVIG). Downregulations of inflammatory response-related genes and IL-17 signaling pathway-related genes were observed in PBMCs.ConclusionWe describe a patient with refractory pemphigus vulgaris and pulmonary tuberculosis who had the disease under control with combined use of dupilumab as an add-on treatment. Dupilumab may provide a beneficial effect in aggressive refractory pemphigus vulgaris.
Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures
Authors: Xie Xiao , Liu Tingting , Wang Wenqi , Tian Ge , Wang Jinyan , Guan Jitian , Chen Meng , Wang Xunchang , Zhou Qingjun 
Published: February 2022

PurposeTo observe and analyze the clinical and multi-mode imaging features of eyes with PHOMS, and to introduce two cases of PHOMS which underwent multi-mode imaging.MethodsRetrospective clinical observational study. A total of 26 patients (37 eyes) with hyperreflective structures surrounded by hyporeflective edges around the optic discs who were examined and diagnosed at Shandong Eye Hospital between January 2019 and June 2021 were included in the study. Among these patients, 12 were male and 14 were female. Fifteen were monocular. The average age was 39 years. All patients underwent the following examinations: Best-corrected visual acuity (BCVA), intraocular pressure examinations, slit-lamp anterior segment examinations, indirect ophthalmoscopy, visual field examinations, fundus color photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA). Some of the patients were examined with fundus fluorescein angiography (FFA). Clinical data and imaging characteristics from the OCT, OCTA, and FFA were analyzed retrospectively.ResultsWe found the hyperreflective structures surrounded by hyporeflective edges around the optic discs in 37 eyes. EDI-OCT results revealed hyperreflective structures surrounded by hyporeflective edges around the optic discs in all eyes. Typical hyperreflexia lesions occurred around the optic disc, located subretinally and above Bruch's membrane. OCTA revealed that the highly reflective perioptic material also had vascular structures.ConclusionEDI-OCT of PHOMS showed hyperreflective structures surrounded by hyporeflective edges around all of the optic discs. Infra-red photography showed temporal hyperreflexia. These characteristics can be seen in a variety of diseases and may be a relatively common feature revealed by EDI-OCT scanning. These characteristics may also be seen in elderly patients as well as children. PHOMS may be found in optic disc drusen (ODD), tilted disc syndrome (TDS), optic neuritis, ischemic optic neuropathy, and in white dot syndromes. Few patients may be developed into macular neovascularization (MNV). In order to improve the accuracy and robustness of the conclusions and provide better clinical guidance, we need to conduct more comprehensive research in the subsequent clinical work.
Analgesic Efficacy of Spinal Morphine in Comparison With Transversus Abdominis Plane Block for Postoperative Pain Management in Patients Undergoing Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial
Authors: Jemal Bedru , Mohammed Fetiha , Tesema Hailemariam Getachew , Ahmed Siraj , Mohammed Ayub , Regasa Teshome , Obsa Mohammed Suleiman 
Published: February 2022

BackgroundCesarean section (CS) has been one of the most frequently performed major surgical interventions and causes severe postoperative pain. Spinal opioid and abdominal field block have been investigated as effective analgesia for postoperative pain and reduce the need for systemic medications and associated side effects. The aim of the current study is to compare spinal morphine (SM) and bilateral landmark oriented transversus abdominis plane (TAP) block for postoperative pain management.MethodIn this randomized controlled trial, 114 pregnant mothers scheduled for CS under spinal anesthesia were allocated randomly to receive either SM 0.1 mg (group SM; n = 56) or bilateral landmark-oriented TAP block with 20 ml of 0.25% of bupivacaine (group TAP; n = 52). A comparison of numerical variables between study groups was done using unpaired student t-test and Mann–Whitney test for symmetric and asymmetric data, respectively. Time to event variable was analyzed by using Kaplan–Meir's survival function. A p-value of &lt; 0.05 was considered statistically significant.ResultA total of 114 patients were recruited and randomly assigned and received interventions. Among them, 108 patients completed this study. Time to first analgesic request was significantly shorter in the TAP block compared to SM. Twenty-four-hour median morphine consumption was reduced in the SM group compared to the TAP block (p &lt; 0.001). Median postoperative pain score during movement and rest shows statistically significant differences between groups (p &lt; 0.001).ConclusionThe addition of preservative-free 100 μg SM provides prolonged postoperative analgesia time, superior postoperative analgesia, and less postoperative opioid consumption compared to the TAP block.
The Relationship Between Convergent IGH Signatures and Severity of COVID-19 Patients by Next-Generation Sequencing of B-Cell Repertoire
Authors: Cai Hongliu , Hu Juan , Huang Lingtong , Gao Chunhua , Xu Mi , Gao Yuzhi , Sun Tao , Fang Xueling 
Published: February 2022

ObjectTo reveal convergent IGH signatures and the association with severity of coronavirus disease 2019 (COVID-19) patients.MethodA total of 25 COVID-19 inpatients were classified into three clinical conditions: mild, severe, and critical. We analyzed convergent IGH signatures by ImmuHub® B-cell receptor (BCR) profiling system.ResultsIGH singleton frequency in patients is significantly lower than that of healthy donors (HDs). The clonality index of IGH in patients is significantly higher than that in HDs. Nevertheless, no significant difference was observed among the three groups. The difference in IGH clonality (top five clones) between post- and pretreatment was significant in the improvement and deterioration groups. Three common public motifs were shared by all COVID-19 patients: ARDYGG, RWYFDY, and YYYYGMDV.ConclusionB cells could recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and produce clonal expansion. Patients who had better outcomes after treatment had higher IGH clonality. Three common public motifs—ARDYGG, RWYFDY, and YYYYGMDV—might be used for vaccine development (ChiCTR2000029626).
Efficacy and Safety of Systemic Treatments Among Colorectal Cancer Patients: A Network Meta-Analysis of Randomized Controlled Trials
Authors: Hoang Tung , Sohn Dae Kyung , Kim Byung Chang , Cha Yongjun , Kim Jeongseon 
Published: February 2022

BackgroundSystemic treatments, namely, either monotherapy or combination therapy, are commonly administered to patients with advanced or metastatic colorectal cancer (CRC). This study aimed to provide the complete efficacy and safety profiles and ranking of systemic therapies for the treatment of unresectable advanced or metastatic CRC.MethodsWe searched PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov from inception until June 30, 2021, and also the bibliographies of relevant studies. Randomized controlled trials comparing two or more treatments, namely, at least capecitabine, 5-fluorouracil, leucovorin, irinotecan, bevacizumab, cetuximab, oxaliplatin, or panitumumab were investigated. A network meta-analysis using the Bayesian approach was performed to compare the efficacy and safety of treatments. The surface under the cumulative ranking curve (SUCRA) was calculated for the probability of each treatment as the most effective. The overall response rate (ORR), disease control rate (DCR), overall survival (OS), progression-free survival (PFS), adverse events (AEs) grade ≥3, and serious adverse events (SAEs) were evaluated.ResultsOne hundred two publications with 36,147 participants were assigned to 39 different treatments. Among 11 treatments with full information on six outcomes, FOLFIRI/FOLFOX/FOLFOXIRI + bevacizumab significantly improved both the ORR and DCR, compared to FOLFIRI. Although FOLFOX and FOLFIRI/FOLFOX + cetuximab significantly prolonged both OS and PFS, treatments were comparable in terms of AEs grade ≥3 and SAEs. The top highest SUCRA values were observed in the FOLFOXIRI + panitumumab group for ORR (96%) and DCR (99%), FOLFIRI + bevacizumab + panitumumab group for OS (62%) and PFS (54%), and FOLFOXIRI + bevacizumab group for AEs grade ≥3 (59%) and SAEs (59%) outcomes.ConclusionsThese findings suggest an available range of systemic treatment therapies with different efficacy and safety profiles with patients. Further investigations of the side effects and mutation status are required to confirm our findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42019127772
Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism
Authors: Maimaiti Buajieerguli , Mijiti Salamaitiguli , Jiang Ting , Xie Yinyin , Zhao Weixuan , Cheng Yu , Meng Hongmei 
Published: February 2022

BackgroundGlioblastoma multiforme (GBM) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric (MC) gliomas involve lesions widely separated in space or time, and MC gliomas involving supra- and infratentorial brain regions are rare. In most cases, the infratentorial lesion is seen after surgical manipulation or radiation therapy; it is typically located in the cerebellum or the cervical region, manifesting as metastasis originating from the brain. Besides, venous thromboembolism in brain tumors is usually seen after craniotomy.Case PresentationWe present an uncommon adult case of symptomatic H3K27M-mutant MC glioblastoma simultaneously present in the brain, fourth ventricle, and cervical and lumbar spinal cord regions accompanied by acute pulmonary artery embolism in an adult woman who had not undergone previous therapeutic interventions. We also review the literature on this interesting presentation.ConclusionOur report highlights that clinicians should be alert to the potential alarming presentation of GBM. The incidence of spinal metastasis of cerebral GBM is increasing. Patients with a prior diagnosis of GBM with or without any new onset in the spinal cord should undergo an early MRI of the spinal cord to confirm the diagnosis at an early stage. While management of GBM remains controversial, more research is needed to explore molecular features of GBM further and develop novel targeted therapies for these patients.
AFF4 Predicts the Prognosis of Colorectal Cancer Patients and Suppresses Colorectal Cancer Metastasis via Promoting CDH1 Expression
Authors: Fang Yi , Cao Hua , Gong Xiaoyong , Chen Yanqing , Zhuang Yugang , Zhou Shuqin , Chen Yuanzhuo , Jiang Yimei , Ji Xiaopin , Peng Hu , Jing Xiaoqian 
Published: February 2022

IntroductionAF4/FMR2 family member 4 (AFF4) is a core component of super elongation complex (SEC) and regulates the transcription elongation of many genes. AFF4 depletion or amplification is associated with multiple cancers, but its role in colorectal cancer (CRC) has not been investigated so far.MethodsqRT-PCR and Western blot analyzed AFF4 expression in the paired clinical CRC tissues. The patients’ overall survival curve was determined using the Kaplan-Meier plotter. In vitro experiments, such as cell proliferation, migration, and invasion, were used to preliminarily ascertain the role of AFF4 in CRC. A CRC cell liver metastasis animal model was well established. Livers were harvested and examined histologically by a series of indicators, such as tumor nodules, liver weight, ALT/AST activity, and tumor cell identification by hematoxylin-eosin (HE) staining.ResultsWe firstly examined the expression of AFF4 in colorectal cancer and normal tissues by collecting paired CRC tissues and adjacent normal tissues, revealing that AFF4 was significantly downregulated in CRC patients and lower expression of AFF4 was correlated with poor prognosis. Next, we observed that presence or absence of AFF4 in CRC cells had no effect on cancer cell proliferation, while AFF4 depletion significantly promoted the migration or invasion of CRC cells in vitro. Furthermore, we confirmed that AFF4 deficiency enhanced the metastatic capacity of CRC cells in vivo. Mechanistically, we found that AFF4 upregulated the transcription of CDH1 gene, which encodes E-cadherin and suppresses the epithelial-mesenchymal transition (EMT). Knockdown of AFF4 interfered with CDH1 transcription, resulting in downregulation of E-cadherin expression and the progression of CRC. Moreover, restored CDH1 expression could rescue the phenotype of CRC cells without AFF4.ConclusionsCollectively, our data demonstrated that AFF4 served as a significant novel regulator of CRC via CDH1 transcriptional regulation and a potential effective therapy target for patients with CRC.