bluuebunny/crossref_metadata_2025_split huggingface dataset:
International expert opinion on optimal treatment of anastomotic leakage after rectal cancer resection: a case-vignette study
Authors: Talboom Kevin , Greijdanus Nynke G. , van Workum Frans , Ubels Sander , Rosman Camiel , Hompes Roel , de Wilt Johannes H. W. , Tanis Pieter J. ,   the TENTACLE-Rectum working group
Published: August 2022

Abstract
Purpose
Little is known about the optimal treatment of anastomotic leakage after low anterior resection (LAR) for rectal cancer and whether treatment strategy depends on leakage features and patient characteristics. The objective of this study was to determine which treatment principles are used by expert colorectal surgeons worldwide.

Methods
In this international case-vignette study, participants completed a survey on their preferred treatment for 11 clinical cases with varying leakage features and two patient scenarios depending on surgical risk (a total of 22 cases).

Results
In total, 42 of 64 invited surgeons completed the survey from 18 countries worldwide. The majority worked at a university training hospital (62%) and had more than 15 years of experience performing LAR for rectal cancer (52%). Early leaks in septic patients were preferably treated by major salvage surgery, to some extent depending on the patient scenario. In early leaks in non-septic patients, drainage and faecal diversion were the cornerstones of the proposed treatment. Endoscopic vacuum therapy was more often proposed than percutaneous drainage. A minority proposed anastomotic reconstruction, more often for larger defects. Treatment of late leaks ranged from watchful waiting, drainage, or transanal repair to major (non-)restorative salvage surgery, with minimal influence of the degree of symptoms on the proposed strategy. Leaks of the blind loop and rectovaginal fistulae showed high variability in the proposed treatment strategy.

Conclusion
This TENTACLE-Rectum case-vignette study demonstrates tailored treatment strategies depending on the clinical type of leak and patient characteristics, with variable degrees of consensus and knowledge gaps which should be addressed in future studies.
Reproductive outcomes from ten years of elective oocyte cryopreservation
Authors: Kasaven Lorraine S. , Jones Benjamin P. , Heath Carleen , Odia Rabi , Green Joycelia , Petrie Aviva , Saso Srdjan , Serhal Paul , Nagi Jara Ben 
Published: August 2022

Abstract
Research question
To assess the relationship between the number of oocytes retrieved during elective oocyte cryopreservation (EOC) cycles with various clinical, biochemical, and radiological markers, including age, body mass index (BMI), baseline anti-Müllerian hormone (AMH), antral follicle count (AFC), Oestradiol level (E2) and total number of follicles ≥ 12 mm on the day of trigger. To also report the reproductive outcomes from women who underwent EOC.

Methods
A retrospective cohort of 373 women embarking on EOC and autologous oocyte thaw cycles between 2008 and 2018 from a single London clinic in the United Kingdom.

Results
483 stimulation cycles were undertaken amongst 373 women. The median (range) age at cryopreservation was 38 (26–47) years old. The median numbers of oocytes retrieved per cycle was 8 (0–37) and the median total oocytes cryopreserved per woman was 8 (0–45). BMI, E2 level and number of follicles ≥ 12 mm at trigger were all significant predictors of oocyte yield. Multivariate analysis confirmed there was no significant relationship between AFC or AMH, whilst on univariate analysis statistical significance was proven. Thirty six women returned to use their cryopreserved oocytes, of which there were 41 autologous oocyte thaw cycles undertaken. There were 12 successful livebirths achieved by 11 women. The overall livebirth rate was 26.8% per cycle. No livebirths were achieved in women who underwent EOC ≥ 40 years old, and 82% of all livebirths were achieved in women who had done so between 36 and 39 years old.

Conclusion
Clinical, biochemical and radiological markers can predict oocyte yield in EOC cycles. Reproductive outcomes are more favourable when cryopreservation is performed before the age of 36, with lower success rates of livebirth observed in women aged 40 years and above.
Racism and psychosis: an umbrella review and qualitative analysis of the mental health consequences of racism
Authors: Lazaridou Felicia Boma , Schubert Saskia J. , Ringeisen Tobias , Kaminski Jakob , Heinz Andreas , Kluge Ulrike 
Published: August 2022

AbstractBlack people and People of Color are disproportionately affected by racism and show increased rates of psychosis. To examine whether racialized migrant groups are particularly exposed to racism and therefore have higher risks for psychosis, this paper (1) systematically assesses rates of psychosis among racialized migrant groups concerning the country of origin, and (2) analyzes interviews regarding the association of racism experiences with psychosis-related symptoms in racialized Black people and People of Color populations in Germany. We present an umbrella review of meta-analyses that report the incidence of positive symptoms (e.g., hallucinations and delusions) and negative symptoms (e.g., apathy and incoherent speech) of diagnosed schizophrenia, other non-affective psychotic disorders (e.g., schizoaffective disorder) or first-episode psychosis among migrants by country of origin. We also report 20 interviews with first- and second-generation migrants racialized as Black and of Color in Germany to capture and classify their experiences of racism as well as racism-associated mental health challenges. In the umbrella review, psychosis risk was greatest when migration occurred from developing countries. Effect size estimates were even larger among Caribbean and African migrants. In the qualitative study, the application of the constant comparative method yielded four subordinate themes that form a subclinical psychosis symptomatology profile related to experiences of racism: (1) a sense of differentness, (2) negative self-awareness, (3) paranoid ideation regarding general persecution, and (4) self-questioning and self-esteem instability. We here provide converging evidence from a quantitative and qualitative analysis that the risk of poor mental health and psychotic experiences is related to racism associated with minority status and migration.
Mental health and the effects on methylation of stress-related genes in front-line versus other health care professionals during the second wave of COVID-19 pandemic: an Italian pilot study
Authors: Tabano Silvia , Tassi Lorenzo , Cannone Marta Giulia , Brescia Gloria , Gaudioso Gabriella , Ferrara Mariarosa , Colapietro Patrizia , Fontana Laura , Miozzo Monica Rosa , Croci Giorgio Alberto , Seia Manuela , Piuma Cristina , Solbiati Monica , Tobaldini Eleonora , Ferrero Stefano , Montano Nicola , Costantino Giorgio , Buoli Massimiliano 
Published: August 2022

AbstractHealthcare workers experienced high degree of stress during COVID-19. Purpose of the present article is to compare mental health (depressive and Post-Traumatic-Stress-Disorders—PTSD—symptoms) and epigenetics aspects (degree of methylation of stress-related genes) in front-line healthcare professionals versus healthcare working in non-COVID-19 wards. Sixty-eight healthcare workers were included in the study: 39 were working in COVID-19 wards (cases) and 29 in non-COVID wards (controls). From all participants, demographic and clinical information were collected by an ad-hoc questionnaire. Depressive and PTSD symptoms were evaluated by the Patient Health Questionnaire-9 (PHQ-9) and the Impact of Event Scale—Revised (IES-R), respectively. Methylation analyses of 9 promoter/regulatory regions of genes known to be implicated in depression/PTSD (ADCYAP1, BDNF, CRHR1, DRD2, IGF2, LSD1/KDM1A, NR3C1, OXTR, SLC6A4) were performed on DNA from blood samples by the MassARRAY EpiTYPER platform, with MassCleave settings. Controls showed more frequent lifetime history of anxiety/depression with respect to cases (χ2 = 5.72, p = 0.03). On the contrary, cases versus controls presented higher PHQ-9 (t = 2.13, p = 0.04), PHQ-9 sleep item (t = 2.26, p = 0.03), IES-R total (t = 2.17, p = 0.03), IES-R intrusion (t = 2.46, p = 0.02), IES-R avoidance (t = 1.99, p = 0.05) mean total scores. Methylation levels at CRHR1, DRD2 and LSD1 genes was significantly higher in cases with respect to controls (p < 0.01, p = 0.03 and p = 0.03, respectively). Frontline health professionals experienced more negative effects on mental health during COVID-19 pandemic than non-frontline healthcare workers. Methylation levels were increased in genes regulating HPA axis (CRHR1) and dopamine neurotransmission (DRD2 and LSD1), thus supporting the involvement of these biological processes in depression/PTSD and indicating that methylation of these genes can be modulated by stress conditions, such as working as healthcare front-line during COVID-19 pandemic.
Visual hallucinosis during hypoperfusion of the right occipito-temporal cortex
Authors: Sanda Nicolae , Escribano Paredes Jose Bernardo , Ferastraoaru Victor 
Published: August 2022

Abstract
Objectives
Positive visual phenomena, although reported in lesions of visual cortex, are often overlooked in patients with acute neurological conditions. Yet, their occurrence without structural abnormalities or other underlying neurological disorders represents a unique observation. This report aims to raise awareness of these phenomena, their implications for understanding visual consciousness and to propose a practical, structured algorithm for the clinical assessment of visual hallucinations related to neurological conditions.

Methods
We describe the clinical presentation and imaging findings in two patients with isolated visual hallucinosis secondary to transitory hypoperfusion.

Results
One patient presented with subocclusion of the right posterior cerebral artery and the other with multifocal arterial abnormalities suggestive of reversible cerebral vasoconstriction syndrome (RCVS). Both presented isolated visual hallucinations and hypoperfusion of the right mesial occipito-temporal cortex. Hallucinated images exhibited peculiarities of certain attributes that were recognized only through guided perceptual analysis performed during their occurrence.

Discussion
Dysfunctions in the visual and attentional networks due to the uneven impact of hypoperfusion on the regions of the mesial occipito-temporal cortex likely contributed to the occurrence of visual hallucinations. The initial impaired awareness of certain image attributes obscured an altered, non-realistic rendering of the hallucinated images. Enhancement of awareness through clinical guidance indicates improved attentional deployment, modulation of visual information processing and hallucination–background integration. These features of the hallucinatory phenomena highlight the critical role of semiological analysis during their occurrence and question the validity of post hoc inquiries.
On the solutions and stability for an auto-parametric dynamical system
Authors: Amer T. S. , Abady I. M. , Farag A. M. 
Published: August 2022

AbstractThe main goal of this study is to look at the motion of a damped two degrees-of-freedom (DOF) auto-parametric dynamical system. Lagrange’s equations are used to derive the governing equations of motion (EOM). Up to a good desired order, the approximate solutions are achieved utilizing the method of multiple scales (MMS). Two cases of resonance, namely; internal and primary external one are examined simultaneously to explore the solvability conditions of the motion and the corresponding modulation equations (ME). These equations are reduced to two algebraic equations, through the elimination of the modified phases, in terms of the detuning parameters and the amplitudes. The kind of stable or unstable fixed point is estimated. In certain plots, the time histories graphs of the achieved solutions, as well as the adjusted phases and amplitudes are used to depict the motion of the system at any instant. The conditions of Routh–Hurwitz are used to study the various stability zones and their analysis. The achieved outcomes are considered to be novel and original, in which the used strategy is applied on a particular dynamical system. The significance of the studied system can be observed in its applications in a number of disciplines, such as swaying structures and rotor dynamics.
Enhanced beetle antennae search algorithm for complex and unbiased optimization
Authors: Qian Qian , Deng Yi , Sun Hui , Pan Jiawen , Yin Jibin , Feng Yong , Fu Yunfa , Li Yingna 
Published: August 2022

AbstractBeetle Antennae Search algorithm is a kind of intelligent optimization algorithms, which has the advantages of few parameters and simplicity. However, due to its inherent limitations, BAS has poor performance in complex optimization problems. The existing improvements of BAS are mainly based on the utilization of multiple beetles or combining BAS with other algorithms. The present study improves BAS from its origin and keeps the simplicity of the algorithm. First, an adaptive step size reduction method is used to increase the usability of the algorithm, which is based on an accurate factor and curvilinearly reduces the step size; second, the calculated information of fitness functions during each iteration are fully utilized with a contemporary optimal update strategy to promote the optimization processes; third, the theoretical analysis of the multi-directional sensing method is conducted and utilized to further improve the efficiency of the algorithm. Finally, the proposed Enhanced Beetle Antennae Search algorithm is compared with many other algorithms based on unbiased test functions. The test functions are unbiased when their solution space does not contain simple patterns, which may be used to facilitate the searching processes. As a result, EBAS outperformed BAS with at least 1 orders of magnitude difference. The performance of EBAS was even better than several state-of-the-art swarm-based algorithms, such as Slime Mold Algorithm and Grey Wolf Optimization, with similar running times. In addition, a WSN coverage optimization problem is tested to demonstrate the applicability of EBAS on real-world optimizations.
Long-term effects of safinamide adjunct therapy on levodopa-induced dyskinesia in Parkinson’s disease: post-hoc analysis of a Japanese phase III study
Authors: Hattori Nobutaka , Kamei Takanori , Ishida Takayuki , Suzuki Ippei , Nomoto Masahiro , Tsuboi Yoshio 
Published: August 2022

AbstractThis post-hoc analysis investigated the long-term effects of safinamide on the course of dyskinesia and efficacy outcomes using data from a phase III, open-label 52-week study of safinamide 50 or 100 mg/day in Japanese patients with Parkinson’s disease (PD) with wearing-off. Patients (N = 194) were grouped using the UPDRS Part IV item 32: with and without pre-existing dyskinesia (pre-D subgroup; item 32 > 0 at baseline [n = 81], without pre-D subgroup; item 32 = 0 at baseline [n = 113]). ON-time with troublesome dyskinesia (ON-TD) increased significantly from baseline to Week 4 in the pre-D subgroup (+ 0.25 ± 0.11 h [mean ± SE], p = 0.0355) but gradually decreased up to Week 52 (change from baseline: − 0.08 ± 0.17 h, p = 0.6224); ON-TD did not change significantly in the Without pre-D subgroup. UPDRS Part IV item 32 score increased significantly at Week 52 compared with baseline in the Without pre-D subgroup, but no UPDRS Part IV dyskinesia related-domains changed in the pre-D subgroup. Both subgroups improved in ON-time without TD, UPDRS Part III, and Part II [OFF-phase] scores. The cumulative incidence of new or worsening dyskinesia (adverse drug reaction) at Week 52 was 32.5 and 5.0% in the pre-D and Without pre-D subgroups, respectively. This study suggested that safinamide led to short-term increasing dyskinesia but may be not associated with marked dyskinesia at 1-year follow-up in patients with pre-existing dyskinesia, and that it improved motor symptoms regardless of the presence or absence of dyskinesia at baseline. Further studies are warranted to investigate this association in more details.Trial registration: JapicCTI-153057 (Registered: 2015/11/02).
Recession coverage using the modified coronally advanced tunnel and connective tissue graft with or without enamel matrix derivative: 5-year results of a randomised clinical trial
Authors: Stähli A. , Duong H. Y. , Imber J. C. , Roccuzzo A. , Salvi G. E. , Katsaros C. , Ramseier C. A. , Sculean A. 
Published: August 2022

Abstract

Objectives
To evaluate the 5-year results of single and multiple recession type (RT) 1 and 2 (Miller I to III) recessions treated with the modified coronally advanced tunnel (MCAT) and connective tissue graft (CTG) with or without an enamel matrix derivative (EMD). The main outcome variable was the stability of obtained root coverage from 6 months to 5 years.

Materials and methods
In 24 patients, both complete and mean root coverage (CRC and MRC) and gain of keratinised tissue (KT) were assessed at 6 months and 5 years after recession coverage by means of MCAT and CTG with or without EMD. Aesthetic outcomes after 5 years were evaluated using the root coverage aesthetic score (RES).

Results
At 5 years, 24 patients with a total of 43 recessions were evaluated. Eight patients (57.14%) of the test and 6 (60.0%) of the control group showed complete root coverage. MRC revealed no statistically significant differences between the two groups, with 73.87 ± 26.83% (test) and 75.04 ± 22.06% (control), respectively. KT increased from 1.14 ± 0.57 mm to 3.07 ± 2.27 mm in the test group and from 1.24 ± 0.92 mm to 3.02 ± 1.55 mm in the control group, respectively.

Conclusion
Treatment of single and multiple RT 1 and 2 recessions by means of MCAT and CTG with or without EMD yielded comparable clinical improvements which could be maintained over a period of 5 years. The additional use of EMD did not influence the clinical outcomes.

Clinical relevance
The use of MCAT + CTG yielded successful coverage of single and multiple RT 1 and 2 gingival recessions, while the additional application of EMD did not seem to influence the results.
A two-stage decision-support approach for improving sustainable last-mile cold chain logistics operations of COVID-19 vaccines
Authors: Andoh Eugenia Ama , Yu Hao 
Published: August 2022

AbstractThe COVID-19 pandemic has become a global health and humanitarian crisis that catastrophically affects many industries. To control the disease spread and restore normal lives, mass vaccination is considered the most effective way. However, the sustainable last-mile cold chain logistics operations of COVID-19 vaccines is a complex short-term planning problem that faces many practical challenges, e.g., low-temperature storage and transportation, supply uncertainty at the early stage, etc. To tackle these challenges, a two-stage decision-support approach is proposed in this paper, which integrates both route optimization and advanced simulation to improve the sustainable performance of last-mile vaccine cold chain logistics operations. Through a real-world case study in Norway during December 2020 and March 2021, the analytical results revealed that the logistics network structure, fleet size, and the composition of heterogeneous vehicles might yield significant impacts on the service level, transportation cost, and CO2 emissions of last-mile vaccine cold chain logistics operations.
Language learning: human capital investment or consumption?
Authors: Huber Matthias , Sommerfeld Ann-Marie , Uebelmesser Silke 
Published: August 2022

AbstractThis paper focuses on foreign language learning as human capital investment or consumption. We apply the human capital investment framework to foreign language learning and enlarge it by the consumption motive. Based on a novel dataset of close to 5000 language course participants in 14 countries worldwide, we estimate individual and country-level determinants of the different motives for language learning and of the expected use of language skills in the labour market. We highlight possible spillovers from the consumption motive to a professional use, which emerge mostly in a “tied-mover” context. This provides guidance for targeted language policies.
Soil greenhouse gas fluxes from tropical vegetable farms, using forest as a reference
Authors: Quiñones Cecille Marie O. , Veldkamp Edzo , Lina Suzette B. , Bande Marlito Jose M. , Arribado Arwin O. , Corre Marife D. 
Published: August 2022

AbstractField-based quantification of soil greenhouse gas emissions from the Philippines’ agriculture sector is missing for vegetable production systems, despite its substantial contribution to agricultural production. We quantified soil N2O emission, CH4 uptake, and CO2 efflux in vegetable farms and compared these to the secondary forest. Measurements were conducted for 13 months in 10 smallholder farms and nine forest plots on Andosol soil in Leyte, Philippines using static chambers. Soil N2O and CO2 emissions were higher, whereas CH4 uptake was lower in the vegetable farms than in the forest. Vegetable farms had annual fluxes of 12.7 ± 2.6 kg N2O-N ha−1 yr−1, −1.1 ± 0.2 kg CH4-C ha−1 yr−1, and 11.7 ± 0.7 Mg CO2-C ha−1 yr−1, whereas the forest had 0.10 ± 0.02 kg N2O-N ha ha−1 yr−1, −2.0 ± 0.2 kg CH4-C ha−1 yr−1, and 8.2 ± 0.7 Mg CO2-C ha−1 yr−1. Long-term high N fertilization rates in vegetable farms resulted in large soil mineral N levels, dominated by NO3– in the topsoil and down to 1-m depth, leading to high soil N2O emissions. Increased soil bulk density in the vegetable farms probably increased anaerobic microsites during the wet season and reduced CH4 diffusion from the atmosphere into the soil, resulting in decreased soil CH4 uptake. High soil CO2 emissions from the vegetable farms suggested decomposition of labile organic matter, possibly facilitated by plowing and large N fertilization rates. The global warming potential of these vegetable farms was 31 ± 2.7 Mg CO2-eq ha−1 yr−1 (100-year time frame).
Identifying Rock Loads on TBM Shields During Standstills (Non-Advance-Periods)
Authors: Unterlass Paul J. , Erharter Georg H. , Marcher Thomas 
Published: August 2022

AbstractTunnel boring machine (TBM) operational data is mostly analysed with respect to data that was recorded during the advance of the TBM. Focusing on data that was recorded during standstills of a gripper TBM, we analyse rock loads that were passively recorded in the cylinders of a small roof support shield. These roof support cylinders are situated beneath the TBM’s shield – extending it against the rock mass during non-advance periods. Equipped with pressure sensors, they enable the unique opportunity of logging rock load variations throughout the tunnel. Hence due to the big amount of resulting data, techniques of unsupervised machine learning (i.e. cluster analysis) are used to automatically pre-process the TBM operational data. Furthermore, regression analysis is used to determine sections of the tunnel where rock loads are mainly occurring on the left or right side respectively. The data driven analysis shows that the main rock loads are occurring on the right side of the TBM which is in good accordance with observation from the construction site, as well as numerical models from literature. This paper contributes towards the understanding of rock load conditions in anisotropic rock masses recorded during the drive of a deep hard rock tunnel.