bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pattern of epistaxis recurrence in patients taking prophylactic acetylsalicylic acid (ASA) from a 10 year cohort
Authors: Stanković Petar , Hoch Stephan , Rudhart Stefan , Stojković Stefan , Wilhelm Thomas 
Published: October 2022

Abstract
Objectives
Epistaxis is the most common otolaryngological emergency and one-third of epistaxis patients regularly take low-dose acetylsalicylic acid (ASA) for the prevention of cardiovascular disease (CVD). The shift in contemporary guidelines identifies little benefit of ASA intake in patients who have not previously had an infarction. Existing evidence confirms ASA intake as a factor for severe epistaxis, while the evidence concerning its impact on recurrence is ambiguous. There are no available studies which justify the administration of these drugs nor are there any studies correlating the effects of these drugs to the SCORE2 CVD risk stratifying scale.

Study design
A retrospective analysis of all admitted epistaxis patients in a tertiary academic hospital for the 10 year period 2011 to 2021.

Methods
Patient data were analysed using the hospital information software. A recurrence was defined as an epistaxis episode requiring hospital readmittance for at least one night. Patients taking anticoagulants were excluded (N = 421).

Results
444 patients were included: 246 were taking ASA and 198 were not (NoASA). ASA patients had more frequent recurrence in general (p = 0.03), more recurrences per patient (p = 0.002), and more changes in bleeding localisation (p = 0.04). Recurrence in the ASA group was associated with lower haemoglobin values (HR 0.62, p < 0.0001), while surgery (HR 6.83, p < 0.0001) was associated with recurrence in the NoASA group. ASA patients had a statistically significant (r 0.33, p = 0.032) correlation between the total number of epistaxis recurrences and SCORE2. The indication for drug intake was highly questionable in as much as 40% of ASA patients. Follow-up time was 5.27 years.

Conclusions
Epistaxis patients taking prophylactic ASA are significantly more burdened by recurrence, because they have more frequent recurrences, a greater number of recurrences per patient, and more changes in bleeding localisations when compared to control patients. The drug indication is questionable in up to 40% of ASA patients, exposing them unnecessarily to recurrence.

Level of evidence
4.
Development of summer skiing days in Austrian glacier ski areas in the first two decades of the twenty-first century
Authors: Mayer Marius , Abegg Bruno 
Published: October 2022

AbstractSummer skiing on glaciers is a leisure activity highly dependent on natural factors like weather and glacier conditions. While the literature agrees that climate change is shaping the fate of summer skiing, longer time series covering both the supply and demand side of glacier/summer skiing, and research that combines natural and non-natural factors affecting the summer ski market are missing. To close this research gap, we conducted a detailed supply-side analysis of nine Austrian glacier ski areas focusing on the number of operating days (in the summer half-year, as well as for meteorological and astronomical summer ski definitions), show how these numbers evolve over time, test how they correlate with meteorological and glaciological data using time-series regression models on a yearly and monthly basis, and highlight how managerial decisions come into play when trying to explain the summer ski supply’s decline. Between 2002 and 2019, summer ski operating days in Austrian glacier ski areas declined by 48.3% in the summer half-year, 65.2% in the meteorological, and 62.3% in the astronomical summer parallel to rising mean temperatures and shrinking glaciers. This decrease is strongest in June to September and weakest in May and October but in two glacier ski areas, the operating days in the summer season remain constant or are even on the rise. This is in line with model results indicating that meteorological and glaciological data only explain parts of the variance of the decline trends. Operators’ agency, strategies, and decisions play an important role underlining that global warming is not monocausally determining summer ski operation.
Auto diagnostic system for detecting solitary and juxtapleural pulmonary nodules in computed tomography images using machine learning
Authors: Karrar Ayat , Mabrouk Mai S. , Abdel Wahed Manal , Sayed Ahmed Y. 
Published: October 2022

AbstractLung cancer is one of the most serious cancers in the world with the minimum survival rate after the diagnosis as it appears in Computed Tomography scans. Lung nodules may be isolated from (solitary) or attached to (juxtapleural) other structures such as blood vessels or the pleura. Diagnosis of lung nodules according to their location increases the survival rate as it achieves diagnostic and therapeutic quality assurance. In this paper, a Computer Aided Diagnosis (CADx) system is proposed to classify solitary nodules and juxtapleural nodules inside the lungs. Two main auto-diagnostic schemes of supervised learning for lung nodules classification are achieved. In the first scheme, (bounding box + Maximum intensity projection) and (Thresholding + K-means clustering) segmentation approaches are proposed then first- and second-order features are extracted. Fisher score ranking is also used in the first scheme as a feature selection method. The higher five, ten, and fifteen ranks of the feature set are selected. In the first scheme, Support Vector Machine (SVM) classifier is used. In the second scheme, the same segmentation approaches are used with Deep Convolutional neural networks (DCNN) which is a successful tool for deep learning classification. Because of the limited data sample and imbalanced data, tenfold cross-validation and random oversampling are used for the two schemes. For diagnosis of the solitary nodule, the first scheme with SVM achieved the highest accuracy and sensitivity 91.4% and 89.3%, respectively, with radial basis function and applying the (Thresholding + Kmeans clustering) segmentation approach and the higher 15 ranks of the feature set. In the second scheme, DCNN achieved the highest accuracy and sensitivity 96% and 95%, respectively, to detect the solitary nodule when applying the bounding box and maximum intensity projection segmentation approach. Receiver operating characteristic curve is used to evaluate the classifier’s performance. The max. AUC = 90.3% is achieved with DCNN classifier for detecting solitary nodules. This CAD system acts as a second opinion for the radiologist to help in the early diagnosis of lung cancer. The accuracy, sensitivity, and specificity of scheme I (SVM) and scheme II (DCNN) showed promising results in comparison to other published studies.
Identification of spatial patterns with maximum association between power of resting state neural oscillations and trait anxiety
Authors: Vidaurre Carmen , Nikulin Vadim V. , Herrojo Ruiz Maria 
Published: October 2022

AbstractAnxiety affects approximately 5–10% of the adult population worldwide, placing a large burden on the health systems. Despite its omnipresence and impact on mental and physical health, most of the individuals affected by anxiety do not receive appropriate treatment. Current research in the field of psychiatry emphasizes the need to identify and validate biological markers relevant to this condition. Neurophysiological preclinical studies are a prominent approach to determine brain rhythms that can be reliable markers of key features of anxiety. However, while neuroimaging research consistently implicated prefrontal cortex and subcortical structures, such as amygdala and hippocampus, in anxiety, there is still a lack of consensus on the underlying neurophysiological processes contributing to this condition. Methods allowing non-invasive recording and assessment of cortical processing may provide an opportunity to help identify anxiety signatures that could be used as intervention targets. In this study, we apply Source-Power Comodulation (SPoC) to electroencephalography (EEG) recordings in a sample of participants with different levels of trait anxiety. SPoC was developed to find spatial filters and patterns whose power comodulates with an external variable in individual participants. The obtained patterns can be interpreted neurophysiologically. Here, we extend the use of SPoC to a multi-subject setting and test its validity using simulated data with a realistic head model. Next, we apply our SPoC framework to resting state EEG of 43 human participants for whom trait anxiety scores were available. SPoC inter-subject analysis of narrow frequency band data reveals neurophysiologically meaningful spatial patterns in the theta band (4–7 Hz) that are negatively correlated with anxiety. The outcome is specific to the theta band and not observed in the alpha (8–12 Hz) or beta (13–30 Hz) frequency range. The theta-band spatial pattern is primarily localised to the superior frontal gyrus. We discuss the relevance of our spatial pattern results for the search of biomarkers for anxiety and their application in neurofeedback studies.
Evaluating the COVID-19 impacts on the construction and demolition waste management and resource recovery industry: experience from the Australian built environment sector
Authors: Shooshtarian Salman , Caldera Savindi , Maqsood Tayyab , Ryley Tim 
Published: October 2022

AbstractThe COVID-19 crisis has brought unprecedented challenges to many sectors, including the built environment. The construction and demolition (C&D) waste management and recovery industry is an essential service provider to this sector. Like other industries, this industry has been affected by the pandemic in many ways. However, in Australia, this impact has not been thoroughly investigated. This study, therefore, explores COVID-19 impacts on the Australian C&D waste recovery and construction industry as the major waste consumer and generator. To achieve this aim, a literature review and a series of semi-structured interviews were conducted with 27 participants representing five stakeholder groups (government, construction, waste recovery, material supplying and consultancy) across five Australian states. The research findings established that there is a critical need for leveraging digital technologies, developing business contingency plans, creating coalitions between government and industry, and diversifying supply chains to reduce supply chain risks. This study also uncovered a range of targeted responses and recommendations to manage pandemic-induced disruptions and improve the circular economy in the industry. Our findings can immediately assist industrial practitioners and government decision-makers in managing the impacts of COVID-19 on the waste recovery activities in C&D waste and other waste streams.

Graphical abstract
Scorched earth tactics of the “Islamic State” after its loss of territory: intentional burning of farmland in Iraq and Syria
Authors: Jaafar Hadi , Sujud Lara , Woertz Eckart 
Published: October 2022

Abstract
Recent literature shows increasing interest in analyzing causes of what was referred to as “unusual” fires in Iraq and Syria in 2019. Here, we examine the causes of uncontrolled and irregular fires within farmlands in parts of the two countries in 2019–2020 and quantify their extent spatiotemporally using a combination of medium and coarse-resolution satellite imagery, land cover, precipitation, temperature data, and multiple sources of armed violence data. Our analysis reveals the extent of the deliberate arson of farmland in Iraq and Northeast Syria in 2019–2020. In comparison, only a few fires of farmland were observed in 2007–2013 in Iraq, and Al-Hassakeh, Syria, that became a stronghold of the Islamic State (IS) in 2013. In 2014–2017, we find evidence for increased farmland fires in various locations that closely tracked the military withdrawal of IS between 2015/2016 and 2017 when it lost most of its territory. We find that although the burned area in wheat-producing regions of Iraq (Ninewa and Kirkuk) and Syria have recently increased, the increase in the percentage burned area of agricultural lands in Iraq’s Ninewa and Kirkuk was not unprecedented. MODIS overestimates burned areas when in low fire activity while it underestimates it when fire activity is high, compared to a Landsat–Sentinel-2 combination. A significant positive relationship (r = 0.83) exists between the number of IS-related incidents and the percent burned agricultural area during 2019, which raises questions about the future strategy of the IS terror group and its use and targeting of the water-food complex.
The Economic Value of Coastal Amenities: Evidence from Beach Capitalization Effects in Peer-to-Peer Markets
Authors: Boto-García David , Leoni Veronica 
Published: October 2022

AbstractCoastal amenities are public goods that represent an important attraction for tourism activities. This paper studies the capitalization effects of beach characteristics using hedonic pricing methods. We examine the implicit economic value of several beach characteristics like sand type, width, longitude, accessibility, or frontage in the Airbnb rental market. Using data for 16,663 Airbnb listings located in 67 municipalities of the Balearic Islands (Spain) during the summer of 2016, together with detailed information about the attributes of 263 beaches, our modelling approach considers interaction terms between the beach amenities and distance to the closest beach. Controlling for a set of listings’ structural characteristics, host attributes and municipality fixed effects, we find that Airbnb guests attach economic value to beach length, the presence of vegetation, the type of coastal frontage and beach accessibility and exclusivity. However, there is no evidence of capitalization effects associated with beach width or the type of sand.
Emerging systemic treatment options in meningioma
Authors: Mair Maximilian J. , Berghoff Anna S. , Brastianos Priscilla K. , Preusser Matthias 
Published: October 2022

Abstract
Purpose
Meningiomas are the most frequently diagnosed intracranial neoplasms. Usually, they are treated by surgical resection in curative intent. Radiotherapy and stereotactic radiosurgery are commonly applied in the adjuvant setting in newly diagnosed atypical (CNS WHO grade 2), and anaplastic (CNS WHO grade 3) meningioma, especially if gross total resection is not feasible, and in recurrent cases. Conversely, the evidence for pharmacotherapy in meningioma is scarce.

Methods
The available literature of systemic treatment in meningioma was screened using PubMed, and ongoing clinical trials were explored using ClinicalTrials.gov.

Results
Classical cytotoxic agents, somatostatin analogs, and antihormone treatments have shown only limited efficacy. In contrast, tyrosine kinase inhibitors and monoclonal antibodies, especially those targeting angiogenic signaling such as sunitinib and bevacizumab, have shown promising antitumoral activity in small phase 2 trials. Moreover, results of recent landmark studies on (epi-)genetic alterations in meningioma revealed potential therapeutic targets which are currently under investigation. These include inhibitors of mammalian target of rapamycin (mTOR), focal adhesion kinase (FAK), cyclin-dependent kinases (CDK), phosphoinositide-3-kinase (PI3K), sonic hedgehog signaling, and histone deacetylases. In addition, clinical trials evaluating immune checkpoint inhibitors such as ipilimumab, nivolumab, pembrolizumab and avelumab are currently being conducted and early results suggest clinically meaningful responses in a subset of patients.

Conclusions
There is a paucity of high-level evidence on systemic treatment options in meningioma. However, interesting novel treatment targets have been identified in the last decade. Positive signals of anti-angiogenic agents, genomically targeted agents and immunotherapy in early phase trials should be confirmed in large prospective controlled trials.
On being stuck: the pandemic crisis as affective stasis
Authors: Bernhardt Fabian , Slaby Jan 
Published: October 2022

AbstractThe Covid-19 pandemic put forth a new kind of affective exhaustion. Being forced to stay at home, diminish social interactions and reduce the scale of their everyday mobility, many people experienced boredom, sluggishness, and existential immobility. While state-imposed pandemic policies changed rapidly, everyday life remained strangely unmoving. A sense of being stuck unfurled―as if not only social life, but time itself had come to a halt. At the same time, there was a latent sense of tension and increased aggressiveness which became manifest not only in protests and riots, but also in the texture of everyday life. In this contribution, we argue that both of these states―the feeling of being stuck, and the feeling that this putative tranquility is nothing but the calm before a storm―can be conceptualized as affective stasis. Through a rearticulation of the ancient concept of stasis, we show that these two at first glance incongruous affective conditions are intricately entangled. In Ancient Greek, the term stasis meant “stand, standing, stance”. Being used in a wide variety of contexts―politics, navigation, sports, rhetoric, medicine, and others―stasis took on different meanings which can be semantically organized around two opposite poles: one is the total absence of motion, and the other is an event of radical and often violent social and political change. Drawing on affect theory, phenomenology, and ancient Greek semantics, we propose affective stasis as a novel conceptual framework for political phenomenology.
The effect of psychosocial interventions on depression, anxiety, and quality of life in hemodialysis patients: a systematic review and a meta-analysis
Authors: Barello Serena , Anderson Gloria , Acampora Marta , Bosio Caterina , Guida Elena , Irace Vincenzo , Guastoni Carlo Maria , Bertani Barbara , Graffigna Guendalina 
Published: October 2022

Abstract
Purpose
Hemodialysis has become a standard therapy for adults with end-stage renal diseases. Adults undergoing hemodialysis have to cope with unique psychological issues that make their care journey particularly fatiguing. In this systematic review and meta-analysis, we aimed to summarize and evaluate the effects of psychosocial interventions on the reduction of anxiety and depression in adults with HDs.

Methods
We included randomized controlled trials and quasi-experimental studies that measure change in depression, anxiety, and quality of life.

Results
We identify three categories of psychosocial interventions delivered to adults undergoing hemodialysis. Based on our analysis, there was a medium effect of psychosocial intervention on depression (SMD − 0.85, 95%CI − 1.17; − 0.52, I2 = 80%, p < 0.01) and anxiety (SMD − 0.99, 95%CI − 1.65; − 0.33, I2 = 88%, p < 0.01) in adults undergoing hemodialysis.

Conclusions
Psychosocial interventions, such as psychological support or relaxation-based therapy, seems all to reduce depression and anxiety in adults undergoing HD. Preliminary evidence suggests that there may be a benefit of psychosocial interventions on the quality of life for adults undergoing HD.
Prospective multicentre randomized double-blind placebo-controlled parallel group study on the efficacy and tolerability of StroVac® in patients with recurrent symptomatic uncomplicated bacterial urinary tract infections
Authors: Nestler S. , Peschel C. , Horstmann A. H. , Vahlensieck W. , Fabry W. , Neisius A. 
Published: October 2022

Abstract
Purpose
To evaluate efficacy and safety of vaccination with StroVac compared to placebo in patients with recurrent urinary tract infections (rUTI).

Material and methods
We performed a prospective, double-blinded, placebo-controlled study in patients with uncomplicated rUTI. Patients received three single intramuscular injections with StroVac every two weeks. Primary endpoint was the number of bacterial urinary tract infections (UTI) over 13.5 months after randomization and adjusted by the respective “baseline” value when comparing verum and placebo group. Secondary endpoints were the number of patients with non-recurrence, time to first recurrence, frequency of recurrences, and patients' self-assessment of quality of life using a validated questionnaire.

Results
376 patients were randomized to both groups between January 2012 and March 2015. Mean age was 44.4 years. Patients were mainly female (98.4%). In the StroVac group (n = 188), the number of UTIs was reduced from 5.5 to 1.2, in the placebo group (n = 188) from 5.4 to 1.3 (p = 0.63). In patients with ≥ 7 UTIs prior to study inclusion, StroVac was statistically significantly superior to placebo (p = 0.048). However, in all other secondary endpoints, no statistical differences between the two groups could be seen (all p > 0.3).

Conclusion
StroVac reduced the number of clinically relevant UTIs like in former studies but did not show statistically significant better results than the chosen placebo. Most likely, that was due to a, since confirmed, prophylactic effect of the chosen placebo itself. Therefore, placebo-controlled and double-blinded studies using a different ineffective placebo preparation are needed to determine the importance of StroVac in prophylaxis of rUTI.
Functional nanoemulsion and nanocomposite microparticles as an anticolorectal cancer and antimicrobial agent: applied in yogurt
Authors: Hashim Ayat F. , Abd-Rabou Ahmed A. , El-Sayed Hoda S. 
Published: October 2022

AbstractGreat concern for human health has led the food industry to focus on functional products. Microparticles based on nanoemulsions (M1) and nanocomposites (M2) were developed to deliver vital agents against colorectal cancer and microbial infection. The functional microparticles were prepared by coating extra virgin olive oil (EVOO), probiotics, and fig leaves extract with sodium alginate (SA) and whey protein concentrate (WPC) using the freeze drying technique. The antimicrobial, cytotoxic, apoptotic, encapsulation efficiency (EE %), release rate, and antioxidant activity were investigated. The yogurt was loaded with microparticles and evaluated microbiology, chemically, and sensory during storage. The results showed that the size of nanoemulsion and nanocomposite was between 476.1 and 517.7 nm, while the zeta potentials were −30.1 and −34.5 mV, respectively. M2 microparticles recorded the lowest IC50 values against human colorectal cancerous Caco-2 and HCT 116 cell lines: 1.10 μg/mL and 15.34 μg/mL, respectively. The inhibition zones were between 11 to 20 and 9 to 18 mm for M1 and M2, respectively. The highest EE% was 89.20% for EVOO and 91.34% for probiotics in M2 microparticles. The induction period of the EVOO from M1 and M2 microparticles was 15.37 h and 13.09 h, respectively. The antioxidant activity was between 78 and 65.8% for M1 and M2 microparticles, respectively. The probiotics in yogurt with microparticles were more than un-coated cells, and the taste of these samples was acceptable during storage. This study suggests that microencapsulation could be considered an interesting therapeutic tool when EVOO and probiotics are used in functional food.