bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoration of Complex Movement in the Paralyzed Upper Limb
Authors: Hasse Brady , Sheets Drew , Holly Nicole , Gothard Katalin , Fuglevand Andrew 
Published: January 2022

Abstract
Functional electrical stimulation (FES) involves artificial activation of skeletal muscles to reinstate motor function in paralyzed individuals. While FES applied to the upper limb has improved the ability of tetraplegics to perform activities of daily living, there are key shortcomings impeding its widespread use. One major limitation is that the range of motor behaviors that can be generated is restricted to a small set of simple, preprogrammed movements. This limitation stems from the substantial difficulty in determining the patterns of stimulation across many muscles required to produce more complex movements. Here we show that machine learning can be used to flexibly identify patterns of muscle stimulation needed to evoke a wide array of multi-joint arm movements. Those patterns were delivered concurrently to 29 upper limb muscles in temporarily paralyzed monkeys. In some cases, the evoked responses matched the desired movements with good fidelity. Because the range of movements that can be produced is virtually unlimited, this approach could greatly expand the repertoire of movements available to individuals with high level paralysis.
A Hierarchical Prediction Method Based on Hybrid-kernel GWO-SVM For Metal Tube Bending Wrinkling Detection
Authors: Zhang Shuyou , Yuan Yujun , wang zili , Lin Yaochen , Jiang Lanfang , Fu Mengyu 
Published: January 2022

Abstract
Metal bending tube is widely used in industry while its forming defects extremely affect the bending quality. Among all defects, the bending-inside wrinkling caused by the non-uniform compressive stress is a zero-tolerated defect, particularly when the tube is for transportation. However, the current wrinkling detection approach, suffering from the lack of insight into wrinkling mechanism, is normally posteriori. To obtain the priori wrinkling condition for a certain go-to-bend tube, we put forward a metal tube bending wrinkling hierarchical prediction method based on hybrid-kernel Gray Wolf Optimizer (GWO) Support Vector Machine (SVM). Three typical kernel combinations are utilized for the GWO-SVM prediction model. To verify the proposed wrinkling prediction method, aluminum alloy series tubes are tested. By constructing the 12 typical designations aluminum alloy tubes’ finite element bending simulation case base, the prediction model is trained through three hybrid-kernel GWO-SVMs, respectively. The results are compared with the traditional SVM and GWO-SVM, which show that the proposed hybrid-kernel GWO SVM model has the best performance for hierarchically predicting bending wrinkling. This proposed prediction method lays the foundation for metal tube bending wrinkling detection.
Earth Without Life 2: A Global Network Model of Abiotic Phosphorus Cycling on Earth Through Time
Authors: Jusino-Maldonado Marcos , Rianço-Silva Rafael , Mondal Javed Akhter , Pasek Matthew , Laneuville Matthieu , Cleaves Henderson James 
Published: January 2022

Abstract
Phosphorus (P) is a crucial structural and bioenergetic component of living systems. P cycles through terrestrial geochemical reservoirs via complex physical and chemical processes. Terrestrial life has altered the fluxes between these reservoirs as it evolved, thus it is of interest to explore planetary P flux evolution in the absence of biology. This is especially true since environmental P availability may have influenced the emergence of life on Earth, and affected life’s ability to alter other geochemical cycles, and these processes may be common to other planets. Geochemical P fluxes likely change as planets evolve, and element cycling models that take those changes into account can provide insights on how P fluxes evolve abiotically. There is considerable uncertainty in many aspects of modern and historical global P cycling, including Earth’s initial P endowment and distribution after differentiation and how P interactions between reservoirs and fluxes have evolved over time. We present here a user-configurable dynamical box model for Earth’s abiological P evolution. This model suggests that in the absence of biology, long term planetary geochemical cycling on planets similar to Earth tend to bring P to surface reservoirs, while biology tends to move P to subductable marine reservoirs.
Subcellular Accumulation and Depuration of Zinc in Periphytic Algae During Episodic and Continuous Exposures
Authors: Cadmus Pete , Friebertshauser Ryan , Brinkman Stephen , Rhein Nayla , Clements William 
Published: January 2022

Abstract
As the severity of extreme precipitation events increases with global climate change, so will episodic pulses of contamination into lotic systems. Periphytic algae represent bioindicator species in most freshwater systems due to their rapid accumulation of toxicants, therefore, it is vital to understand how accumulation differs across temporally variable exposure regimes. This ability to rapidly accrue contaminants additionally has implications for the trophic transfer of metals to primary consumers. While dietary toxicity has been studied in algivorous consumers, techniques used to prepare contaminated periphytic algae for consumption have not been compared. This study used a modified subcellular fractionation method to compare the partitioning of Zinc (Zn) in periphyton cultures exposed for variable durations (cultured in the presence of Zn and 15 min, 24 hr, and 48 hr exposures). Three exposure groups were additionally depurated over a period of 24 hr in order to compare retention of Zn; an important aspect of preparing diets used in dietary toxicity studies. Results not only provide evidence for increased retention by periphytic algae cultured in the presence of Zn but reveal relationships among treatments and subcellular partitioning that suggest time-dependent accumulation and detoxification. These relationships ultimately suggest that episodic exposure of periphytic algae to contaminants may pose a greater risk than that of chronic regimes. Based on these results, we additionally advocate for the culturing of periphytic algae in the presence of contamination in order to produce a more reliable diet for dietary exposure testing in algivorous organisms.
MBLDP-R: A Multiple Biomolecules Based Rapid Life Detection Protocol Embedded in a Rover Scientific Subsystem for Soil Sample Analysis
Authors: Zaman Akib , Ashraf Fardeen , Khan Haseena , Noshin Faria , Samir Oiliullah , Rayhan Asif Mahmud , Nazifa Sadia Nur , Chowdhury Hafsah Mahzabin , Rahman Mahbubur 
Published: January 2022

Abstract

A rapid multiple biomolecules based life detection protocol (MBLDP-R) from soil samples is proposed to embed in a scientific rover subsystem targeted for planetary analysis missions complying the guidelines of Science Mission of University Rover Challenge 2021 (URC 2021). The proposed protocol selects suitable biomolecules from a preliminary list through a requirement analysis driven filtration process emphasizing two factors: a) rules of URC 2021 and b) compatibility of the biomolecule test equipment to be embedded in a rover subsystem. To sort out the best test methods for finally selected biomolecules, a weighted qualitative test scoring methodology is applied. A rover subsystem that implements the protocol was built to perform onboard sample analysis. Evaluation results show that: 1) ) the proposed MBLDP-R protocol could effectively predict the classes with an average f1-score of 98.65% (macro) and 90.00% (micro) and the area under the Receiver Operating Characteristics (AUC-ROC) curve shows the sample categories to be correctly predicted 92% of the time (97% Extant, 88% Extinct and 92 % in case of NPL) and 2) the protocol is time-efficient with an average completion time of 17.60 minutes that demonstrates the rapid nature of the protocol to detect bio signatures in soil samples.
Machine Learning-Based Classifiers To Predict Metastasis in Colorectal Cancer Patients
Authors: Borumandnia Nasrin , Akbari Abolfazl , Gramifar Mohammad , Talebi Atefeh , Pourhoseingholi Mohamad Amin , Azizpour Mazaher , Tabaeian Seidamir Pasha , Sedaghat Meghdad 
Published: January 2022

Abstract
Background: The increasing prevalence of colorectal cancer (CRC) in the past three decades in Iran has made it as a key public health burden. The goal of the study was to predict the metastasis in CRC patients using machine learning approach. Methods: This study is focused on 1127 CRC patients, who underwent proper treatments in tertiary Taleghani Hospital. The machine learning approach including Naive Bayes (NB), Random Forest (RF), Support Vector Machine (SVM), Neural Network (NN), Regression Tree (RT) and Logistic Regression (LR) were used for the prediction of metastasis in CRC. Receiver operating characteristic (ROC) curve, sensitivity, specificity and AUC were carried out to evaluate the performance of the approaches Results: Out of 1127 patients, 183(16%) experienced metastasis. In prediction of metastasis, the NN and RF had the most sensitivity. Also the specificity of NN and DT were greater in comparison to other methods. The NN had the highest AUC (0.99%), topmost sensitivity (98.5%) and accuracy (99.6%).Conclusion: Both tumor stage and size of tumor were regarded as indispensable variables in RF model, whereas the NN generally outperformed other ML-based approaches.
Novel Mechanism of Lowering Blood Pressure by Electroacupuncture:MicroRNA9/P2RX7
Authors: Yue Bing-Nan , Sun Jiao , Zhou Zi-Xian , Li Xiao-Lu , Liu Xin , Liu Qing-Guo 
Published: January 2022

Abstract
Backgroud Our previous studies have reported electroacupuncture(EA) can regulate the relevant indicators of essential hypertension(EH) such as angiotensinII(ANGII),ANG(1-7) and inflammatory cytokines.But the mechanism of EA remains unclear. The goal of this study was to verify P2RX7 as one direct target of miRNA-9,which triggers the release of ANGII and PICs(TNF-α, IL-6)in the PVN.The system of miRNA-9/P2RX7 might be a novel mechanism of lowering blood pressure.Method Spontaneously Hypertensive Rats(SHRs) were selected as an animal model of hypertension while WKY rats were considered as a blank group.Bipolar cannula implantation were used to inject inhibitors in the paraventricular nucleus(PVN).We measured the systolic blood pressure(SBP) of animals on different days of acupuncture therapy(0,3,7,10,14).We examined the level of microRNA-9 by RealTime-PCR.RT-PCR and western blot was utilized to detect the mRNA and protein levels of P2RX7 in each group.The activation of microglias was detected by immunohistochemistry staining with antibody Iba1.ANGII,IL-6 and TNF-α were detected by ELISA in the PVN and plasma.Results Our results showed that EA reduces systolic blood pressure of SHRs.EA increased the level of miR-9 notably comparing to sham groups.In addition,SHRs in the EA group had significantly lower P2RX7 protein and mRNA levels than those in the sham group,while miR9-inhibitor downregulated the expression of P2RX7 in the PVN comparing to EA groups. Immunohistochemistry staining showed that EA treatment and P2RX7 inhibitor significantly inhibited the activation of microglia.We also found that the combination of P2RX7-inhibitor and EA had a better anti-inflammatory effect and better inhibition of ANGII,while using miR9-inhibitor prevented the effect.Conclusion Taken together, our data demonstrates that P2RX7 is a direct downstream receptor of miRNA-9.Regulating system, miRNA-9/P2XR7, decreases the release of ANGII and alleviates inflammation in the PVN and plasma of SHRs,which indicates a novel microRNA-mediated mechanism of EA.Furthermore, the present investigation provides the combination treatment of P2RX7-inhibitor and EA as a better intervention in the area of anti-inflammatory.
In Vitro Anticancer and Antibacterial Activity of Green Synthesized ZnO NPs Using Clitorea Ternatea Flower Extract: Inhibits MCF-7 Cell Proliferation Via Intrinsic Apoptotic Pathway
Authors: Alahmdi Mohammed Issa , Syed Khasim , Vanaraj Sekar , Panneerselvam Chellasamy , Mahmoud Mahmoud A Abdelaziz , Mukhtar Sayeed , Alsharif Meshari A , Zidan Nahla S , Abo-Dya Nader Elmaghwry , Aldosari Obaid F 
Published: January 2022

Abstract
Herein, we report a strategy to synthesize zinc oxide nanoparticles (ZnO NPs) from Clitorea ternatea flower extract through green synthesis platform. The bioactive components in the C. ternatea flower extract acts as a stabilizing and capping agent, which enables the synthesis of ZnO NPs without the use of chemical reagents. Synthesis of of ZnO NPs through green platform was confirmed by analytical characterization techniques such as UV-Vis spectrophotometry, XRD, FTIR, DLS, Zeta potential, TEM, and EDX methods. The surface morphology and average size of ZnO NPs investigated through TEM and DLS results indicates rod shaped structure with average particle size of 84 nm. Green synthesized ZnO NPs shows excellent antibacterial, antibiofilm, and antioxidant activity which is dose-dependent. These ZnO NPs have cytotoxicity against breast cancer cells (MCF-7). The MTT test revealed a concentration-dependent inhibitory effect on MCF-7 cells, with IC50 being 12.1 g/ml, and their anticancer potential was detected utilizing live and dead cell assays LDH release, Ao/EtBr), DAPI, ROS, and caspase-3 activation assays. Finally, the findings of these results shows that ZnO NPs derived from Clitorea ternatea flower extract are highly potential candidates to treat bacterial infection and human breast cancer.
Spin-1/2 one- and two- particle systems in physical space without eigen-algebra or tensor product
Authors: Andoni Sokol 
Published: January 2022

Abstract
A novel representation of spin 1/2 combines in a single geometric object the standard Pauli spin operator and spin state. Under the spin-position decoupling approximation it consists of the sum of three orthogonal vectors comprising a gauge phase. In the one-spin case the representation: (1) is Hermitian; (2) endowed with handedness; (3) yields all standard results, including the total spin angular momentum; (4) relates basis spins by proper rotations, thus preserving handedness; (5) allows formalizing irreversibility in spin measurement. In the bipartite case: (1) entangled spins have precisely related gauge phases and opposite handedness; (2) maximally entangled spins relate by one of the four improper rotations in 3D: plane-reflections (triplets) and inversion (singlet); (3) the full spin expressions yield the standard total two-spin angular momentum; (4) all standard expected values for bipartite observations follow. Depending on whether spin operations act one – or two – sided, the formalism appears in two complementary forms, the ‘spinor’ or the ‘vector’ form, respectively. The proposed scheme provides a clear geometric picture of spin transformations and correlations in the 3D physical orientation space.
The Possible Protective Effect of Hepatitis B Vaccine against Lymphomas: A Systematic Review
Authors: La Torre Giuseppe , Lia Lorenza , Grima Daniela , Amici Francesca , Manzi Linda , Monaci Alessandro 
Published: January 2022

Background:
In the last few years, the possible etiological role of the Hepatitis B virus
(HBV) in the outbreak of extrahepatic pathologies has been studied, including lymphomas. The
World Health Organization (WHO) estimates that around 257 million people live with chronic
HBV infection, and to date, the vaccine is the most effective means of prevention.

Objective:
The aim of this review was to evaluate whether the vaccination against Hepatitis B can
lead to a reduction in lymphoma cases and has a protective role.

Methods:
A literature search was conducted in April 2020 using the databases Scopus, PubMed,
and ISI Web of Science. Search terms included: “Hepatitis B vaccination AND lymphoma.” All
articles evaluating the association between Hepatitis B vaccination and the prevention of lymphoma
were selected. No limits were applied.

Results:
Eight studies were eligible to be included in the review. Data showed that association
between lymphoma and HBV infection is not the same for all types of lymphomas, but it appears
to be more significant for Non-Hodgkin Lymphoma (NHL). The results from all the considered
articles were not unitary. This is because studies were conducted in different countries with different
endemicity of Hepatitis B, different vaccination coverage, treatment of chronic Hepatitis, and
prevention of its complications, as well as the availability of data for researchers. No statistically
significant association was found between HBV vaccination and the development of lymphomas.

Conclusion:
Although the literature is still largely lacking regarding the protective effect of anti-
HBV vaccination on lymphoma subtypes, the association between HBV infection and lymphoma
has been confirmed in several studies. Vaccination programs eliminate the risk of HBV infection
and prevent liver disease but can also indirectly reduce the risk of lymphomas.
Targeting Options of Tumor-Associated Macrophages (TAM) Activity in
Gliomas
Authors: Anagnostakis Filippos , Piperi Christina 
Published: January 2022

Abstract:
Tumor-associated macrophages (TAMs), the most plastic cells of the hematopoietic system,
exhibit increased tumor-infiltrating properties and functional heterogeneity depending on tumor
type and associated microenvironment. TAMs constitute a major cell type of cancer-related inflammation,
commonly enhancing tumor growth. They are profoundly involved in glioma pathogenesis,
contributing to many cancer hallmarks such as angiogenesis, survival, metastasis, and immunosuppression.
Efficient targeting of TAMs presents a promising approach to tackle glioma progression.
Several targeting options involve chemokine signaling axes inhibitors and antibodies, antiangiogenic
factors, immunomodulatory molecules, surface immunoglobulins blockers, receptor and
transcription factor inhibitors, as well as microRNAs (miRNAs), administered either as standalone
or in combination with other conventional therapies. Herein, we provide a critical overview of current
therapeutic approaches targeting TAMs in gliomas with the promising outcome.
Magnesium Sulphate-Catalyzed Green and Efficient Synthesis of Some
New Derivatives of 1-Amido Alkyl Naphthols under Solvent-Free Conditions
Authors: Chavhan Namdeo M. , Bhakare Sagar D. , Muthe Rohit C. , Hande Sayaji Y. , Gandule Amol S. , Gaikwad Dhananjay N. , Suryawanshi Dayanand M. 
Published: January 2022

Abstract:
The present work describes an efficient, green, and direct approach for the synthesis of amido
alkyl naphthols via one-pot multicomponent solvent-free reaction (MCR) of substituted aromatic
aldehydes, β-naphthols, and urea by the use of easily available, non-toxic, and cost-effective Lewis
acid catalyst magnesium sulphate (MgSO4.7H2O). The important characteristics of this reaction include
the following: eco-friendly and mild reaction conditions, excellent yields of the products, shorter
reaction time, economically cheaper and environmentally friendly catalyst MgSO4.7H2O. Also, clean
reaction, non-column purification, and operational simplicity are some of the additional significant
features of this approach.
Breast Cancer Risk and Human Papillomavirus Infection: A Bradford Hill Criteria Based Evaluation
Authors: Usman Muhammad , Hameed Yasir , Ahmad Mukhtiar , Jalil Ur Rehman  , Ahmed Hamad , Hussain Muhammad Safdar , Asif Rizwan , Murtaza Muhammad Ghulam , Jawad Muhammad Tayyab , Iqbal Muhammad Junaid 
Published: January 2022

Background:The association between human papillomavirus (HPV) and human breast cancer (BC) has already been thoroughly studied worldwide with contradictory findings. Although the researchers have tried to minimize the conflict using statistical meta-analysis because of its shortcomings, there is still a need to evaluate the correlation between HPV and BC using any additional method.Objectives:This study was launched to investigate the correlation between HPV and BC through the application of Bradford Hill criteria postulates.Methods:Population-wide studies associating HPV with BC were searched using the PubMed database. Then, the information of HPV burden in BC, normal/benign samples was analyzed, and ultimately Bradford Hill criteria postulates were applied on the collected evidence to explore the relationship between HPV and BC. In addition, to make the outcomes more authentic, we also reviewed the methodologies of previous studies to address the propensity of false results.Results:After a careful evaluation of the obtained data against major Bradford Hill criteria postulates, it was noted that all these postulates, including strength, consistency, biological gradient, temporality, plausibility, experiment, specificity, and analogy were not fulfilled.Conclusion:The results of the present study have failed to establish a causal association between HPV and BC, but they did suggest HPV as a cause-effective agent or at least a co-participant in the pathogenesis of BC. Because of the weakness of association, particularly the lack of consistency between studies and the lack of effect specificity, more research into Bradford Hill criteria postulates is required.
Contribution of Oncology Pharmacists in Cancer Care: A Need for Quality
Care
Authors: Rawal Kala Bahadur , Mateti Uday Venkat , Shetty Vijith , Shastry Shashidhara Chakrachodi , Joel Juno Jerold , Shetty Shraddha 
Published: January 2022

Abstract:
Cancer is known as a disease with a high morbidity and mortality rate. There are several
short-term and long-term complications of cancer, leading to poor quality of life. Cancer in advanced
stage and malignant tumors requiring a multisystem involvement makes the treatment challenging.
The diverse health impact of cancer requires a multidisciplinary approach for treatment.
The oncology pharmacy has facilitated a revolutionary approach for preparing and training specialised
pharmacists to deal with a variety of health challenges faced by cancer patients. Oncology
pharmacists or oncopharmacists are the experts in designing drug therapy and individualizing it in
accordance with the requirements. The conventional and novel role of pharmacists in clinical pharmacy
practice is documented to positively impact the health of cancer patients, including cancer
survivors. Hence, this review tries to summarize the potential role of oncopharmacists.
A Bibliometric Analysis of the Reliability Assessment Technology Based on
Accelerated Degradation
Authors: Li Shiyun , Tang Shujue , Pei Zhi , Lv Ruifeng 
Published: January 2022

Background:
In the face of the development trend of high-end manufacturing servitization,
the reliability standard of manufacturing products gradually increases.

Objective:
In order to accurately predict the product life cycle, the accelerated degradation evaluation
technology could be applied to significantly shorten the experiment duration. As the technologies of intelligent
manufacturing and industrial big data develop, the theory of accelerated degradation evolves as
well.

Methods:
Based on the scientific knowledge mapping, co-author network and co-existence network,
22283 pertinent articles since the year 2010 have been collected to conduct a bibliometric study.

Results:
The results show that the accelerated degradation reliability assessment spans over many research
fields, and achieves great development in the mathematical modeling and experiment verification.

Conclusion:
To further the study, more efforts are expected in the areas such as building effective evaluation
systems and enhancing the credibility of the assessment outcomes, as more advanced sensory data
and wireless communication technologies become available.