bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Last Citizen of the Grand Duchy of Lithuania: The Editor Ludwik Abramowicz (1879–1939) and the Idea of "Krajowość"
Authors: Smalianchuk Aliaksandr 
Published: December 2021

The Last Citizen of the Grand Duchy of Lithuania: The Editor Ludwik Abramowicz (1879–1939) and the Idea of KrajowośćLudwik Abramowicz was one of the main ideologists of the idea of krajowość in its liberal-democratic version. He defended its principles even in the interwar period, when Poland was dominated by the policy of assimilation of national minorities and relations with Lithuania had the character of a cold war. Thanks to Abramowicz, Przegląd Wileński [Vilnius Review] (1921–1938) became the last bastion of the idea of krajowość, actively popularising it in the public life of the Vilnius Region. Abramowicz unwaveringly defended the idea of the political independence of the Belarusian-Lithuanian Lands and the decision of its future by the representatives of all indigenous nations. Abramowicz’s life and work, his publications in Przegląd Wileński prove that against all political and national-cultural realities, the idea of krajowość as an idea of harmonious coexistence of the nations of the historical Lithuania was popular and found new supporters. Ostatni obywatel Wielkiego Księstwa Litewskiego. Wprowadzenie do biografii redaktora Ludwika Abramowicza (1879–1939)Publicysta i redaktor Ludwik Abramowicz był jednym z głównych ideologów idei krajowej w jej liberalno-demokratycznej wersji. Bronił zasad krajowości nawet w dwudziestoleciu międzywojennym, kiedy w Polsce dominowała polityka asymilacji mniejszości narodowych, a stosunki z Litwą miały charakter zimnej wojny. Dzięki Abramowiczowi „Przegląd Wileński” (1921–1938) stał się ostatnim bastionem idei krajowej, czynnie popularyzując ją w życiu publicznym Wileńszczyzny. Abramowicz konsekwentnie bronił idei politycznej niezależności Kraju Białorusko-Litewskiego i decydowania o jego losie przez przedstawicieli wszystkich rdzennych narodów. Życie i twórczość Abramowicza, publikacje w „Przeglądzie Wileńskim” świadczą, że wbrew wszelkim realiom politycznym i narodowo-kulturowym idea krajowa jako idea harmonijnego współistnienia narodów historycznej Litwy cieszyła się popularnością i znajdowała nowych zwolenników.
Extended Antisemitism: The Case of Poznań
Authors: Roszak Joanna 
Published: December 2021

Extended Antisemitism: The Case of PoznańThis article examines contemporary antisemitism in Poznań. The first part of the study reconstructs how the contemporary collective memory in this Polish city was shaped, starting in the interwar period. Referring to earlier contexts, the author points to the founding myth of the medieval legend of the stolen Hosts, which prevails in Poznań. She also retraces the history of antisemitism at the Adam Mickiewicz University. In recent years, the university has disclosed archival records, including those connected with the introduction of ghetto benches and the numerus clausus rule, in this way attempting to atone for disgraceful events in its history. Reflecting on antisemitism in Poznań, the author asks what fuels it in the almost mono-ethnic city that Poznań is today, and introduces the term extended antisemitism. For the purposes of the article, she conducted interviews (using the Delphi technique) with researchers and social activists involved in Jewish issues. Antysemityzm rozszerzony: na przykładzie PoznaniaAutorka bada współczesny antysemityzm w Poznaniu. W pierwszej części opracowania rekonstruuje, jak kształtowała się współczesna pamięć zbiorowa w tym polskim mieście, począwszy od okresu międzywojennego. Następnie, odwołując się do kontekstów, wskazuje na dominujący w Poznaniu mit założycielski średniowiecznej legendy o skradzionych hostiach. Omawia też historię antysemityzmu na Uniwersytecie im. Adama Mickiewicza. W ostatnich latach uczelnia ujawnia źródła archiwalne, w tym materiały związane z tworzeniem getta ławkowego i z wprowadzeniem numerus clausus; w ten sposób stara się niejako zadośćuczynić haniebnym wydarzeniom ze swojej historii. Zastanawiając się nad antysemityzmem w Poznaniu, autorka zadaje pytanie, czym napędza się on dziś w niemal monoetnicznym mieście. Wprowadza pojęcie rozszerzonego antysemityzmu. Na potrzeby artykułu przeprowadziła wywiady metodą delficką z badaczami i społecznikami.
Personal meaning of recovery among persons with schizophrenia
Authors: Mathew Shari Tess , Nirmala Bergai Parthsarathy , Kommu John Vijay Sagar 
Published: December 2021

Background: Recovery in mental illness is not synonymous with cure. Personal recovery approach consider recovery as a process and not as an outcome. This approach takes into account the subjective meaning of recovery by assessing how a person has learned to accommodate and live with an illness. Aim: To study the personal meaning of recovery among persons with schizophrenia. Method: This article presents the findings of a qualitative study about what ‘recovery’ means to persons with schizophrenia. A semi structured interview schedule was prepared based on literature review and expert opinion. Twenty participants who met the inclusion criteria and personally consider themselves recovering/recovered from schizophrenia were selected for the in-depth qualitative interviews. Data was analyzed using Interpretative Phenomenological Analysis (IPA). Meaning of recovery from each participant’s perspective was recorded. Findings: The results indicate factors that patients deem important for their recovery are, absence of symptoms, regaining functioning, being able to work, having adequate emotional stability and not being on medicines. The findings are examined in the background of the previous studies and suggestions for clinical practice and research is also discussed. Conclusion: Recovery is far more than remission of symptoms. Persons with mental illness has their own criteria of recovery, which could be very distinct from the clinical definition. Current study findings can help in identifying meaning of recovery through the perspectives of persons with mental illness and in developing and implementing recovery-oriented services.
Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans
Authors: Highland Jaclyn N , Farmer Cristan A , Zanos Panos , Lovett Jacqueline , Zarate Carlos A , Moaddel Ruin , Gould Todd D 
Published: December 2021

Background: Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when compared to males, higher levels of ( 2R,6R;2S,6S)-HNK have been observed following ketamine treatment, and higher levels of ( 2R,6R)-HNK following the direct administration of ( 2R,6R)-HNK. Aim: The objective of this study was to evaluate the impact of sex in humans and mice, and gonadal hormones in mice on the metabolism of ketamine to form norketamine and HNKs and in the metabolism/elimination of ( 2R,6R)-HNK. Methods: In CD-1 mice, we utilized gonadectomy to evaluate the role of circulating gonadal hormones in mediating sex-dependent differences in ketamine and ( 2R,6R)-HNK metabolism. In humans (34 with treatment-resistant depression and 23 healthy controls) receiving an antidepressant dose of ketamine (0.5 mg/kg i.v. infusion over 40 min), we evaluated plasma levels of ketamine, norketamine, and HNKs. Results: In humans, plasma levels of ketamine and norketamine were higher in males than females, while ( 2R,6R;2S,6S)-HNK levels were not different. Following ketamine administration to mice (10 mg/kg i.p.), Cmax and total plasma concentrations of ketamine and norketamine were higher, and those of ( 2R,6R;2S,6S)-HNK were lower, in intact males compared to females. Direct ( 2R,6R)-HNK administration (10 mg/kg i.p.) resulted in higher levels of ( 2R,6R)-HNK in female mice. Ovariectomy did not alter ketamine metabolism in female mice, whereas orchidectomy recapitulated female pharmacokinetic differences in male mice, which was reversed with testosterone replacement. Conclusion: Sex is an important biological variable that influences the metabolism of ketamine and the HNKs, which may contribute to sex differences in therapeutic antidepressant efficacy or side effects.
The utility of dual-energy computed tomography angiography for the evaluation of brain aneurysms after endovascular coiling: a prospective study
Authors: Dolati Parviz , Ogilvy Christopher S 
Published: December 2021

Background Non-invasive alternatives to digital subtraction angiography (DSA) for follow-up of patients with coiled aneurysms are sought. Purpose To compare a novel method of dual-energy computed tomography angiography (DE-CTA) for postoperative assessment of coiled brain aneurysms to detect aneurysm recanalization and patency of adjacent blood vessels, with DSA. Material and Methods Patients who underwent endovascular cerebral aneurysm coiling were prospectively evaluated postoperatively by both DE-CTA and conventional DSA. CTA was performed using a novel dual-energy method with single-source and fast kilovoltage switching. DSA was performed using biplanar cerebral angiography. An experienced neuroradiologist and neurosurgeon, both blinded to the original radiological results, reviewed the images. Results A total of 54 patients (16 men, 38 women; mean age=47.6 + 9 years) with 55 coiled aneurysms were enrolled in our study between July 2014 and June 2015: 29 patients had suffered a subarachnoid hemorrhage and 26 patients had an incidentally found cerebral aneurysm. All patients had at least one DSA and DE-CTA performed at most one week apart. DE-CTA showed a 100% sensitivity and specificity in detection of complete aneurysm occlusion and 80% sensitivity and specificity for detection of residual necks and domes. DE-CTA successfully detected all vascular diameter changes as comparable to DSA with minimal interfering artifact. Conclusion DE-CTA is a promising non-invasive alternative to conventional catheter-based angiography for identification of aneurysm recurrence and assessment of adjacent arteries after endovascular coiling. It allows for far more rapid image acquisition than DSA, is non-invasive, and is widely available at clinical centers.
Use of ABC/2 method for rapidly estimating the target mismatch on computed tomography perfusion imaging in patients with acute ischemic stroke
Authors: Shen Guang-Chen , Chu Yue , Ma Gao , Xu Xiao-Quan , Lu Shan-Shan , Shi Hai-Bin , Wu Fei-Yun 
Published: December 2021

Background Target mismatch (ischemic core, mismatch volume and mismatch ratio) in patients with acute ischemic stroke (AIS) highly relies on the automated perfusion analysis software. Purpose To evaluate the feasibility and accuracy of using the ABC/2 method to rapidly estimate the target mismatch on computed tomography perfusion (CTP) imaging in patients with AIS, using RAPID results as a reference. Material and Methods In total, 243 patients with anterior circulation AIS who underwent CTP imaging were retrospectively reviewed. Target mismatch associated perfusion parameters were derived from RAPID results and calculated using the ABC/2 method. Paired t-test was used to assess the difference of volumetric parameters between the two methods. The ability of using the ABC/2 method to predict the important cutoff volumetric metrics was also evaluated. Result There was no significant difference in the volumes of ischemic core ( P = 0.068), ischemic area ( P = 0.209), and mismatch volume ( P = 0.518) between ABC/2 and RAPID. Using RAPID results as reference, the ABC/2 method showed high accuracy for predicting perfusion parameters (70 mL and 90 mL: sensitivity=98.5% and 98.5%, specificity=100% and 100%, positive predictive value [PPV]=100% and 100%, negative predictive value [NPV]=93.8% and 92.9%; 10 mL and 15mL: sensitivity=99.6% and 99.5%, specificity=55.6% and 50.0%, PPV=96.6% and 94.8%, NPV=90.9% and 92.3%; 1.2 and 1.8: sensitivity=99.6% and 94.8%, specificity=75.0% and 96.9%, PPV=98.7% and 99.5%, NPV=90.0% and 73.8%). Conclusion The ABC/2 method may be a feasible alternative to RAPID for estimation of target mismatch parameters on CTP in patients with AIS.
Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients
Authors: Perea-Seoane Luciana , Agapito-Vera Estefania , Gamboa-Cardenas Rocío V , Guzmán-Sánchez Geny , Pimentel-Quiroz Victor Román , Reategui-Sokolova Cristina , Medina Mariela , Elera-Fitzcarrald Claudia , Noriega Erika , Rodriguez-Bellido Zoila , Pastor-Asurza Cesar , Perich-Campos Risto , Alarcón Graciela S , Ugarte-Gil Manuel F 
Published: December 2021

Objective To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients. Methods Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders. Results 266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains. Conclusion A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients’ HRQoL.
The frequency and characteristics of multiple sclerosis misdiagnosis in Latin America: A referral center study in Buenos Aires, Argentina
Authors: Gaitán María I , Sanchez Melanie , Farez Mauricio F , Fiol Marcela P , Ysrraelit Maria C , Solomon Andrew J , Correale Jorge 
Published: December 2021

Objective: Most contemporary data concerning the frequency and causes of multiple sclerosis (MS) misdiagnosis are from North America and Europe with different healthcare system structure and resources than countries in Latin America. We sought to determine the frequency, and potential contributors to MS misdiagnosis in patients evaluated at an MS referral center in Argentina. Methods: The study was a retrospective medical record review. We included patients evaluated at the MS Clinic at Fleni between April 2013 and March 2021. Diagnoses prior to consultation, final diagnoses after consultation, demographic, clinical and paraclinical data, and treatment were extracted and classified. Results: Seven hundred thirty-six patients were identified. Five hundred seventy-two presented with an established diagnosis of MS and after evaluation, misdiagnosis was identified in 89 (16%). Women were at 83% greater risk of misdiagnosis ( p = 0.034). The most frequent alternative diagnoses were cerebrovascular disease, radiological isolated syndrome (RIS), and headache. Seventy-four (83%) of misdiagnosed patients presented with a syndrome atypical for demyelination, 62 (70%) had an atypical brain magnetic resonance imaging (MRI), and 54 (61%) were prescribed disease-modifying therapy. Conclusion: Sixteen percent of patients with established MS were subsequently found to have been misdiagnosed. Women were at higher risk for misdiagnosis. Expert application of the McDonald criteria may prevent misdiagnosis and its associated morbidity and healthcare system cost.
Impact of Frailty and Age on Clinical Outcomes in Patients Who Underwent Endovascular Therapy
Authors: Nishikawa Ken , Ebisawa Soichiro , Miura Takashi , Kato Tamon , Yusuke Kanzaki , Abe Naoyuki , Yokota Daisuke , Yanagisawa Takashi , Senda Keisuke , Wakabayashi Tadamasa , Oyama Yushi , Karube Kenichi , Itagaki Tadashi , Yui Hisanori , Maruyama Shusaku , Nagae Ayumu , Sakai Takahiro , Okina Yoshiteru , Nakazawa Shun , Tsukada Shunichi , Saigusa Tatsuya , Okada Ayako , Motoki Hirohiko , Kagoshima Mitsuru , Kuwahara Koichiro 
Published: December 2021

Purpose: Information on the relationship between frailty and the outcome of endovascular therapy (EVT) in older patients with lower extremity peripheral artery disease (PAD) is scarce. This study aimed to reveal the impact of frailty on the prognosis of older population who underwent EVT. Materials and Methods: From August 2015 to August 2016, 335 consecutive patients who underwent EVT were enrolled in the I-PAD registry from 7 institutes in Nagano prefecture. Among them, we categorized 323 patients into 4 groups according to age and the presence or absence of frailty as follows: older patients with frailty (age ≥ 75, Clinical Frailty Scale [CFS] ≥ 5), older patients without frailty (age ≥ 75, CFS ≤ 4), young patients with frailty (age < 75, CFS ≥ 5), and young patients without frailty (age < 75, CFS ≤ 4); we analyzed them accordingly. The primary endpoints were major adverse cardiovascular and limb events (MACLE), defined as a composite of cardiovascular death, myocardial infarction, stroke, admission for heart failure, major amputation, and revascularization. The secondary endpoint was cardiovascular death. Results: The median follow-up period was 2.7 years. In the older patients with frailty, older patients without frailty, young patients with frailty, and young patients without frailty groups, the freedom rates from MACLE were 34.9%, 55.7%, 35.4%, and 63.0%, respectively (p<0.001) and from all-cause death were 43.5%, 73.4%, 50.7%, and 90.9%, respectively (p<0.001). The freedom rates from MACLE were significantly higher among older patients with frailty than among young patients without frailty (55.7% vs 35.4%, p=0.01). In multivariate analysis, frailty was independently associated with MACLE incidence. Conclusion: Frailty as defined by CFS might be a predictor of MACLE incidence in patients with PAD who underwent EVT. By considering treatment indications for patients with PAD by focusing on frailty rather than age, we may examine whether EVT policies are appropriate and manage patient and caregiver expectations for potential improvement in functional outcomes. Further studies are expected to investigate whether changes in frailty after EVT change prognosis.
Aortic Intramural Hematoma due to Intercostal Artery Aneurysms
Authors: Shehab Maysam , Wolf Ammie , Ajaj Mones , Greton Igal , Fajer Simmone 
Published: December 2021

Background Intercostal artery aneurysms (ICA) are rare vascular disease. A rupture of ICA is a possible mechanism of intramural aortic hematoma (IH). We report a case with IH and ICAs without clear etiology. Case presentation: A 64-year-old man was admitted to our emergency room with a sudden onset of acute diffused abdominal and chest pain, radiating to the back. Without previous traumatic insult, a computed tomographic angiography scan (CTA) revealed an IH beginning inferior to the left subclavian artery extending to the level of the celiac trunk. Follow-up CTA demonstrated a stable maximal IH thickness diameter of 11 mm, maximal aortic diameter of 40 mm, a new left hemorrhagic pleural effusion, and a focal contrast enhancement at T9 level. Due to these findings, thoracic endovascular aortic repair (TEVAR) was performed. During follow up, T9 focal enhancement continues to grow and an additional one developed. Selective angiography was performed demonstrating a connection to the costal artery and the aortic lumen, confirming ICA. Successful embolization with micro coils was performed. During follow up, additional 2 ICAs developed and treated with embolization. CTA three months later showed a complete resolution of the IH and obliteration of all treated ICAs. Infectious, inflammatory and connective tissue disease investigations were undertaken without a clear etiology. Conclusions: This is a case of IH and ICAs, in the absence of a clear etiology which were successfully treated by endovascular procedures TEVAR and coil embolization. It is not clear whether the hematoma was the source of the ICA or the other way round. Lack of ICAs in the initial CTA might be due to the pressure exerted by the hematoma or that they were too small to be detected but continued to grow on follow up. Rupture of these micro-aneurysms is a possible mechanism of intramural aortic hematoma.
Wedeven Associates: Finding New Ways to Develop Novel Solutions to Persistent, Intractable Problems
Authors: Jonsen Richard H 
Published: December 2021

Wedeven Associates is a small tribology research and engineering consulting firm located near Philadelphia, Pennsylvania. The company faced a variety of challenges associated with the COVID-19 pandemic as did most small businesses in 2020. As the company became fully operational again, Wedeven Associates was approached by a longtime client to solve a tribological problem the client’s engineers had been trying to address for many years. The catch: Wedeven Associates only had a little over 2 months to do the work while complying with pandemic-related travel and meeting restrictions. This case tells the story of how the Wedeven Associates team met the challenge using virtual tools and a collaborative approach built on first principles. Readers are introduced to “tribology” as an engineering discipline and “first principles” as a problem-solving approach.
Trend in survival after out-of-hospital cardiac arrest and its relationship with bystander cardiopulmonary resuscitation: a six-year prospective observational study in Beijing
Authors: Chen Yuling , Yue Peng , Wu Ying , Li Jia , Lei Yanni , Gao Ding , Liu Jiang , Han Pengda 
Published: December 2021

Abstract
Background
Out-of-hospital cardiac arrest (OHCA), a global health problem with a survival rate ranging from 2 to 22% across different countries, has been a leading cause of premature death for decades. The aim of this study was to evaluate the trends of survival after OHCA over time and its relationship with bystander cardiopulmonary resuscitation (CPR), initial shockable rhythm, return of spontaneous circulation (ROSC), and survived event.

Methods
In this prospective observational study, data of OHCA patients were collected following the “Utstein style” by the Beijing, China, Emergency Medical Service (EMS) from January 2011 (data from February to June in 2011 was not collected) to October 2016. Patients who had a cardiac arrest and for whom an ambulance was dispatched were included in this study. All cases were followed up to determine hospital discharge or death. The trend of OHCA survival was analyzed using the Chi-square test. The relationship among bystander CPR, initial shockable rhythm, ROSC, survived event, and OHCA survival rate was analyzed using multivariate path analyses with maximum standard likelihood estimation.

Results
A total of 25,421 cases were transferred by the Beijing EMS; among them, 5042 (19.8%) were OHCA (median age: 78 years, interquartile range: 63–85, 60.1% male), and 484 (9.6%) received bystander CPR. The survival rate was 0.6%, which did not improve from 2012 to 2015 (P = 0.569). Overall, bystander CPR was indirectly associated with an 8.0% (β = 0.080, 95% confidence interval [CI] = 0.064–0.095, P = 0.002) increase in survival rate. The indirect effect of bystander CPR on survival rate through survived event was 6.6% (β = 0.066, 95% CI = 0.051–0.081, P = 0.002), which accounted for 82.5% (0.066 of 0.080) of the total indirect effect. With every 1 increase in survived event, the possibility of survival rate will directly increase by 53.5% (β = 0.535, 95% CI = 0.512–0.554, P = 0.003).

Conclusions
The survival rate after OHCA was low in Beijing which has not improved between 2012 and 2015. The effect of bystander CPR on survival rate was mainly mediated by survived event.
Trial registration
Chinese Clinical Trial Registry: ChiCTR-TRC-12002149 (2 May, 2012, retrospectively registered). http://www.chictr.org.cn/showproj.aspx?proj=7400