bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secretory phenotype of the human endothelial cells associated with replicative and induced aging
Authors: Савицкий Д.В. , Линькова Н.С. , Кветной И.М. , Дятлова А.С. , Сараев Г.Б. , Козлов К.Л. , Пальцева Е.М. 
Published: October 2022

Секреторный фенотип, ассоциированный со старением (SASP), - гетерогенный фенотип клеток, секретирующих провоспалительные цитокины, факторы роста, апоптоза и протеазы. SASP является одним из трех основных признаков стареющих клеток. Нарушение регуляции синтеза молекул, формирующих SASP, приводит к развитию ассоциированных с возрастом заболеваний, в том числе сердечно-сосудистой патологии. Цель исследования - охарактеризовать SASP эндотелиоцитов человека при репликативном и индуцированном старении. Для моделирования репликативного и вызванного воспалением старения использовали линию изолированных эндотелиальных клеток пупочной вены человека HUVEC. Установлено, что молекулами, формирующими SASP при репликативном и индуцированном воспалением старении HUVEC, являются факторы апоптоза (p16, p21, p53), адгезии (Е-селектин, VCAM-1) и цитокины (IL-1β, IL- 6). При репликативном старении эндотелиоцитов в большей степени повышается синтез молекул апоптоза. Для индуцированного воспалением старения HUVEC характерно многократное увеличение синтеза молекул адгезии и провоспалительных цитокинов.
The aging-associated secretory phenotype (SASP) is a heterogeneous phenotype of cells secreting pro-inflammatory cytokines, growth factors, apoptosis’ regulatory molecules, and proteases. SASP is one of the three main hallmarks of senescent cells. Dysregulation of the synthesis of SASP-forming molecules leads to the development of age-associated diseases, including cardiovascular pathology. The aim of this study is to characterize the SASP of human endotheliocytes during replicative and induced aging. Isolated human umbilical vein endothelial cells HUVEC were used to model replicative and inflammation-induced aging. It has been established that the molecules that form SASP during replicative and inflammation-induced aging of HUVEC are molecules that control apoptosis (p16, p21, p53), adhesion (E-selectin, VCAM-1) and some cytokines (IL-1β, IL-6). With replicative aging of endotheliocytes, the synthesis of apoptosis’ regulatory molecules increases to a greater extent. Inflammation-induced aging of HUVEC is characterized by a multiple increase in the synthesis of adhesion molecules and pro-inflammatory cytokines.
Clinical aspects of diagnosis and treatment of glossodynia in elderly and senile people
Authors: Борисова Э.Г. , Раевский К.П. , Абшеев А.Е. , Алтухова А.Б. 
Published: October 2022

Глоссодиния - это сложное в диагностике и лечении заболевание. Лица старшей возрастной группы наиболее подвержены риску его возникновения. Это связано с тем, что этиологическими факторами становятся возрастные изменения, общесоматические заболевания, прием некоторых фармакологических препаратов, изменение психоэмоционального фона. Ввиду схожести клинической картины глоссодинии с другими заболеваниями полости рта, от врача требуется тщательная диагностика и дифференциальная диагностика для постановки верного диагноза. Применяют клинические методы обследования, уделяя наибольшее внимание сбору анамнеза жизни и заболевания, оценке личностно-эмоциональной сферы пациента. Также используют клинико-функциональные, клинико-инструментальные и лабораторные методы исследования. В лечении глоссодинии стоит уделять внимание не только устранению симптомов, но и ее профилактике. Основные усилия следует направить на борьбу с основными звеньями патогенеза. Лечение должно быть комплексным, дифференцированным и персонифицированным. В результате трудов многих исследователей разработаны определенные принципы диагностики и лечения глоссодинии, которые и будут рассмотрены в нашей работе.
Glossodynia is a disease that is difficult to diagnose and treat. Persons of older age groups are in the most risk of its occurrence. This is due to the fact that its etiological factors are: age-related changes, general somatic diseases, usage of some pharmacological drugs, changes in the psycho-emotional background. Due to the similarity of the clinical picture of glossodynia with other diseases of the oral cavity, the doctor is required to be thoughtful when diagnosing and differentiating glossodynia. Clinical methods of examination are used, paying most attention to the anamnesis of life and disease, assessment of the personal and emotional sphere of the patient. Clinico-functional, clinico-instrumental, and laboratory methods of examination are also used. In the treatment of glossodynia, attention should be paid not only to the elimination of symptoms, but also to its prevention. The main efforts should be aimed at combating the main links of pathogenesis. Treatment should be comprehensive, differentiated and personalized. As a result of many researchers work, certain principles of diagnostics and treatment of glossodynia have been developed, which will be considered in our work.
The use of antidepressants for the treatment of chronic pain: a focus on elderly patients
Authors: Ушкалова Е.А. , Зырянов С.К. , Бутранова О.И. 
Published: October 2022

Возможным инструментом повышения эффективности и безопасности ведения пациентов пожилого и старческого возраста с хронической болью может являться использование адъювантных анальгетиков, в частности антидепрессантов. Имеющиеся клинические данные указывают на возможность использования антидепрессантов в качестве альтернативы опиоидным анальгетикам и нестероидным противовоспалительным средствам. Обзор посвящен анализу сравнительных характеристик и особенностям назначения трициклических антидепрессантов, селективных ингибиторов обратного захвата серотонина и норадреналина, селективных ингибиторов обратного захвата серотонина в качестве обезболивающих средств пациентам пожилого возраста. Представлены рекомендации по применению антидепрессантов у пожилых пациентов с различными типами боли, направленные на минимизацию возможных нежелательных реакций и повышение качества жизни данной категории больных.
A possible tool to improve the efficacy and safety of managing elderly and senile patients with chronic pain may be the use of adjuvant analgesics, in particular, antidepressants. Available clinical data indicate the possibility of using antidepressants as an alternative to opioid analgesics and non-steroidal anti-inflammatory drugs. The review includes the analysis of the comparative characteristics and peculiarities of prescribing tricyclic antidepressants, selective serotonin and norepinephrine reuptake inhibitors, and selective serotonin reuptake inhibitors as painkillers in elderly patients. Recommendations are given on the use of various representatives of the antidepressant group in elderly patients with various types of pain, aimed at minimizing possible adverse drug reactions and improving the quality of life of this category of patients.
SINTESIS NANOPARTIKEL EKSTRAK KULIT BATANG TANAMAN KAYU JAWA (Lannea coromandelica) TERSALUT KITOSAN
Authors: . Hartati , Insaniah Fitratul , Mu'nisa Andi , Pagarra Halifah 
Published: October 2022

Extract of Kayu Jawa (Lannea coromandelica) bark plant is known to have biological activity, one of which is antibacterial. This research aimed to determine the inhibition of nanoparticles kayu jawa (Lannea coromandelica) bark against Stapylococcus aureus and Eschericia coli. The extraction of Kayu Jawa (Lannea coromandelica) bark was carried out by maceration method using 70% ethanol as solvent. The extract of the Kayu Jawa (Lannea coromandelica) bark was synthesized to form chitosan-coated nanoparticles using the ionic gelation method and the results of the synthesis were characterized using X-Ray Difraction (XRD). The results showed that the synthesis of nanoparticles extract of Kayu Jawa (Lannea coromandelica) bark coated with chitosan had a particle size of 24.9 nm.
Analisis Kompetensi Pedagogik Guru dalam Pembelajaran Fisika sebagai Implementasi Kurikulum 2013 di SMA Negeri Kota Makassar
Authors: Sari Salamang Salmiah , Darwis Zaima Nur Iwana , Khaeruddin K , Susanto Jack 
Published: October 2022

Penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif yang bertujuan untuk menganalisis penguasaan kompetensi pedagogik guru fisika SMAN di Kota. Sampel penelitian dipilih secara acak sebanyak 8 orang guru yang berasal dari 8 sekolah yang ditentukan secara cluster random sampling berdasarkan akreditasi sekolah, guru yang telah bersertifikasi dari Tahun 2007 sampai dengan 2014, guru yang telah mengikuti tes uji kompetensi pedagogik Tahun 2015 dan 2017, dan guru yang telah mengikuti pelatihan Kurikulum 2013 lebih dari tiga kali. Data dikumpulkan dengan cara pemberian kuesioner dan observasi untuk mengukur kompetensi pedagogik guru dan pengkajian dokumentasi RPP untuk mengukur indikator pengembangan kurikulum, selanjutnya dianalisis secara statistik deskriptif. Hasil analisis data menunjukkan indikator (1) penguasaan karakteristik peserta didik memperoleh nilai rata-rata 75,47 dengan kategori cukup, (2) penguasaan teori belajar dan prinsip-prinsip pembelajaran yang mendidik memperoleh nilai rata-rata 76,41 dengan kategori baik, (3) penguasaan pengembangan memperoleh nilai rata-rata sebesar 67,19 dengan kategori cukup, (4) penguasaan melaksanakan kegiatan yang mendidik memperoleh nilai rata-rata sebesar 75,00 dengan kategori baik, Secara keseluruhan dalam penguasaan kompetensi pedagogik guru fisika SMAN di kota Makassar dalam kategori baik.Kata kunci: Kompetensi Pedagogik, Kurikulum 2013, Guru Fisika. This research is a descriptive study with a quantitative approach that aims to analyze the mastery of the pedagogical competence of the physics teacher of SMAN in Makassar. The sample of the study was randomly selected as many as 8 teachers from eight schools determined by cluster random sampling based on school accreditation, teachers who have been certified from 2007 to 2014, teachers who have taken the pedagogical competency test in 2015 and 2017, and teachers who have attended the 2013 Curriculum training more than three times. Data were collected by giving questionnaires and observations to measureStudent Assessment of Lecturer Performance, Learning Motivation, And Attitudes Towards teacher's pedagogical competencies and reviewing lesson plans to measure indicators of curriculum development, then analyzed by descriptive statistics. The results of the analysis of the data show the indicators (1) the mastery of the characteristics of students gained an average value of 75,47 with a sufficient category, (2) mastery of learning theory and principles of learning that educate an average score of 76,41 with a good category, ( 3) mastery of development obtains an average value of 67,19 with a sufficient category, (4) mastery of carrying out educational activities obtaining an average value of 75,00 with a good category. Overall in mastering the pedagogical competence of high school physics teachers in Makassar in the good category.Keywords: Pedagogical competence, Curriculum 2013, Physics teacher.
Pengaruh Formulasi Pakan Terhadap Kandungan Nutrisi Larva Black Solder Fly (BSF) Hermetia illucens.
Authors: Hartati Hartati , Chamila Ainun , Syamsiah Syamsiah , Jumadi Oslan , Kurnia Nani , Junda Muhammad , Sahribulan Sahribulan , Djawad Yasser Abd. , Harianto Fajar 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh variasi formulasi pakan Black soldier fly (BSF) Hermetia illucens yang terdiri dari limbah ikan dan sayuran terhadap kandungan nutrisi larva BSF. Jenis penelitian ini adalah eksperimen dengan menggunakan 4.000 larva BSF yang telah memasuki fase instar dua. Pemeliharaan larva BSF dilakukan selama 15 hari. Pemberian pakan dilakukan sekali dalam 2-3 hari. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 3 perlakuan dan 3 kali ulangan. Perlakuan A yaitu 10% limbah ikan : 90% limbah sayuran, B yaitu 20% limbah ikan : 80% limbah sayuran, C yaitu 30% limbah ikan : 70% limbah sayuran. Parameter yang diamati yaitu Kandungan nutrisi dalam tubuh larva BSF dianalisis menggunakan analisis proksimat. Data hasil analisis proksimat dianalisis menggunakan analysis of variance (ANOVA) dan Uji lanjut Duncan dengan taraf kepercayaan 95%, Hasil penelitian menunjukkan perlakuan C dengan 30% limbah ikan dan 70% limbah sayur memberikan hasil yang terbaik dengan kandungan protein tertinggi dibandingkan perlakuan A dan B. Maka dapat disimpulkan bahwa variasi formulasi pakan berpengaruh signifikan terhadap kandungan nutrisi larva BSF Hermetia illucens. Kata kunci: Formulasi pakan, Nutrisi, Hermetia illucens.This study aims to determine the effect of variations in the feed formulation Black soldier fly (BSF) Hermetia illucens consisting of fish and vegetable waste on the nutritional content of BSF larvae. This type of study is an experiment using 4,000 BSF larvae that have entered the instar phase two. The maintenance of BSF larvae is carried out for 15 days. Feeding is carried out once in 2-3 days. This study used a Randomized Group Design (RAK) with 3 treatments and 3 repeats. Treatment A is 10% fish waste: 90% vegetable waste, B is 20% fish waste: 80% vegetable waste, C is 30% fish waste: 70% vegetable waste. The observed parameters, namely the content of nutrients in the body of BSF larvae was analyzed using proximate analysis. The data from the proximate analysis were analyzed using analysis of variance (ANOVA) and Duncan's advanced test with a confidence level of 95%, the results of the study showed that the behavior ofC with 30% of fish waste and 70% of vegetable waste gave the best results with the highest protein content compared totreatments A and B. to the nutritional content of the larvae of BSF Hermetia illucens.Keywords: Feed formulation, Nutrition, Hermetia illucens.
Implementasi Model Pembelajaran Kooperatif Tipe NHT (Numbered-Head-Together) untuk Meningkatkan Hasil Belajar IPA Siswa Kelas IX B SMP Negeri 4 Alla Enrekang
Authors: Murwanto Sri 
Published: October 2022

Hasil observasi di SMP Negeri 4 Alla Kabupaten Enrekang diperoleh fakta yang menunjukkan bahwa dalam proses pembelajaran masih banyak permasalahan di dalamnya yang dapat dilihat dari hasil belajarnya. Permasalahan tersebut diantaranya: guru masih mengajar menggunakan metode konvensional dan hasil belajar siswa yang masih rendah. Sedangkan dari hasil tanya jawab dengan guru mata pelajaran IPA rata-rata hasil belajar IPA siswa kelas IX B SMP Negeri 4 Alla Enrekang pada tahun pelajaran 2018/2019 awal semester ganjil masih sangat rendah. Masalah tersebut timbul akibat model mengajar guru yang masih bersifat monoton yaitu, guru lebih aktif dibandingkan siswanya. Hal ini tentu saja akan berdampak pada kebermaknaan belajar yang berujung pada keberhasilan belajar. Penelitian ini merupakan penelitian tindakan kelas (PTK) yang terdiri atas tahapan perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Subjek penelitian adalah siswa kelas IX B SMP Negeri 4 Alla Enrekang tahun pelajaran 2018/2019. Hasil belajar siswa diukur dengan menggunakan tes esay setiap akhir siklus. Hasil penelitian menunjukkan bahwa implementasi model pembelajaran kooperatif type NHT (Numbered-Head-Together) dapat meningkatkan hasil belajar IPA Siswa Kelas IX B SMP Negeri 4 Alla Enrekang.Kata kunci: Model pembelajaran kooperatif, Number-Head-Together, Hasil belajar IPAObservation results at SMP Negeri 4 Alla Enrekang Regency obtained facts that refer to the learning process there are still many problems that can be seen from the results of learning. This issue is issued: the teacher still uses conventional methods and student learning outcomes are still low. While the results of questions and answers with natural science subject teachers the average learning outcomes of students of class IX B of SMP Negeri 4 Alla in the 2018/2019 academic year at the start of the odd semester were still very low. The problem arises because the teacher's teaching model is still monotonous, that is, teachers are more active than their students. This of course will have an impact on meaningful learning that leads to successful learning. This research is a classroom action research (CAR) consisting of planning, implementing, observing, and reflecting. The research subjects were students of class IX B SMP Negeri 4 Alla Enrekang in the 2018/2019 academic year. Student learning outcomes use essay tests at the end of each cycle. The results showed that the implementation of the NHT (Numbered-Head-Together) type of cooperative learning model could improve the learning outcomes of Science IX Class B students of SMP Negeri 4 Alla Enrekang.Keywords: Cooperative learning model, Number-Head-Together, Science learning outcomes.
Model SEIR Kecanduan Game Online pada Siswa di SMP Negeri 3 Makassar
Authors: Side Syafruddin , Muzakir Nurul Azizah , Pebriani Dian , Utari Syana Nurul 
Published: October 2022

Penelitian ini membahas model matematika SEIR kecanduan game online. Data yang digunakan adalah data primer berupa jumlah siswa SMP Negeri 3 Makassar yang kecanduan game online yang diperoleh dengan cara membagikan angket kepada siswa. Penelitian ini dimulai dari membangun model SEIR kecanduan game online, menentukan titik keseimbangan, menganalisis kestabilan titik keseimbangan, menentukan nilai bilangan reproduksi dasar ( 𝑅0) , melakukan simulasi model menggunakan software Maple, dan menginterpretasikan hasil simulasi. Dalam artikel ini diperoleh model matematika SEIR kecanduan game online; dua titik keseimbangan, yaitu titik keseimbangan bebas kecanduan dan titik keseimbangan kecanduan; kestabilan titik keseimbangan bebas kecanduan dan kecanduan; serta bilangan reproduksi dasar 𝑅0 = 0,089 yang menunjukkan bahwa tidak terjadi penularan kecanduan dari satu individu ke individu lain.Kata kunci: Model Matematika, Kecanduan Game Online, Model SEIR. This research discuss a SEIR mathematical model of online game addiction. The data used is primary data of the number of students in Junior High School 3 Makassar who are addicted to online game which obtained by share the questionnaires to students. This research starts from constructing a SEIR model of online game addiction, determining the equilibrium point, analysing the stability of equilibrium point, determining the basic reproduction number (𝑅0), doing a simulation of model using Maple, and interpreting the result of the simulation. In this paper we obtained a SEIR mathematical model of online game addiction; two equilibrium points which are addiction free and addiction equilibrium point; the stability of addiction free and addiction equilibrium; and the basic reproduction value𝑅0 = 0,089 indicates that there is no transmission of addiction from one individual to another.Keywords: Mathematical Model, Game Online Addiction, SEIR Model
Pengabdian Kepada Masyarakat “Moderasi Beragama Untuk Penguatan Karakter Bangsa Di Tingkat Remaja Pada SMAN 2 Martapura Kalimantan Selatan”
Authors: Arief Muhammad Ihsanul , Maisarah Maisarah , Husin Gt. Muhammad Irhamna , Mailita Mailita , Ainah Noor , Yusuf Muchamad , Ramadhan Hisyam 
Published: October 2022

<p><em>Indonesia adalah negara yang multiagama dan multietnis. Keragaman negara ini memberi gambaran bahwa negara kepulauan ini memiliki kekayaan yang tidak dimiliki negara lain. Hubungan harmoni antar masyarakat harus kita jaga sebaik-baiknya agar jati diri bangsa ini memiliki marwah di mata dunia Internasional. Potensi ancaman kelompok ekstrim yang mengarah pada sikap radikal harus diantisipasi sejak dini. Para remaja harus dipersiapkan agar menjadi bagian yang mampu membentengi paham radikal yang tidak sejalan dengan ajaran agama yang moderat. Kegiatan pengabdian kepada masyarakat yang dilaksanakan oleh tim dosen merupakan bentuk sosialisasi dengan tema “</em><em>Moderasi Beragama Untuk Penguatan Karakter Bangsa Di Tingkat Remaja Pada SMA Negeri 2 Martapura, Kalimantan Selatan</em><em>”, yang memberikan kontribusi pemahaman terhadap siswa/siswi tingkat remaja. Pemahaman moderasi beragama bukan hanya sekeder konsep, tetapi.harus mengarah pada pengamalan dalam hidup sehari-hari. Ukuran keberhasilan dari kegiatan pengabdian ini dapat terukur dari hasil respon siswa dan siswi terhadap kemudahan dalam memahami materi dibuktikan</em><em> dengan 32.8% menjawab sepakat atau bisa mereka pahami dengan baik. Dan sebanyak 25.4% menjawab sangat sepakat atau sangat mudah mereka pahami. Berikutnya respon terkait seberapa besar potensi materi yang telah disampaikan dapat diterapkan melalui hasil respon jawaban “ya” sebanyak 77.7%. Terkait relevansi materi siswa dan siswi menjawab setuju sebanyak 33.4%, dan partisipan yang menjawab sangat setuju sebanyak 34.1%. Terakhir, respon siswa dan siswa terkait manfaat kegiatan, katagori sangat setuju yaitu sebanyak 64.1% . Siswa dan siswi yang menjawab setuju 23.3%. Semua respon jawaban memberikan kesimpulan materi moderasi beragama dapat dipahami dan diamalkan siswa dan siswi kalangan remaja. Hal demikian memberikan energi positif untuk selalu dilaksanakan kegiatan ini. Selain itu mereka pada hakikatnya penerus bangsa ini pada generasi selanjutnya. Jika tidak sekarang mereka dipupuk dengan paham cinta tanah air dan berbangsa yang setia, maka sulit kita banyangkan bagaimana Indonesia di masa depan.</em></p>
Discussion on the Differences Between the Cyclic Spectral Correlation and Coherence for Cyclostationarity-Based Condition Monitoring
Authors: Kestel Kayacan , Peeters Cédric , Antoni Jérôme , Léclere Quentin , Girardin Franc ̧ois , Brijder Robert , Helsen Jan 
Published: October 2022

Vibration signals measured on rotating machinery typically exhibit cyclostationarity due to the inherent nature of real-world rotating vibration sources. Hence, the development of signal processing tools devoted to investigating or exploiting this cyclostationarity for condition monitoring purposes of gears and bearings has seen a significant increase in research interest. One of the main approaches to analyze a vibration signal’s cyclostationary behavior is the cyclic spectral correlation and its normalized derivative the cyclic spectral coherence. Even though these two methods are closely related, they do offer different statistical insights which may influence the fault detection and trending capabilities of these tools. The aim of this work is to investigate the performance of these two methods with regard to the accuracy of tracking mechanical degradation over time. The normalization of the spectral coherence which makes it independent of the signal power spectrum improves the interpretability of the resulting coherence spectrum but it may lead to suppress or equalize fault-related frequency bands relative to other frequency bands and it may skew the coherence spectrum amplitudes of fault harmonics in different operating regimes for complex machinery. Tracking the evolution of a second-order cyclostationary component over time might thus be hindered by this normalization which can lead to issues when combining such a tool with a data-driven machine learning technique that employs the operating conditions for making the cyclostationary indicators operating condition independent. Instead, using the cyclic spectral correlation which is not normalized, may provide a more accurate depiction of the degradation process. This paper investigates whether there is any significant benefit to using the cyclic spectral correlation over the cyclic spectral coherence for monitoring complex rotating machinery and if so, when does it make sense to prefer one over the other. To answer these questions, both simulated and experimental vibration data is examined in order to highlight the differences between the two concepts.