bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Use of Percutaneous Dissolvable Sutures During COVID-19 Pandemic: A Retrospective Review
Authors: Gallop Joshua , Andrasik Wyatt , Lucas Jennifer 
Published: December 2022

Background The COVID-19 pandemic has had dramatic effects on all fields of medicine, including an effort to limit in-person visits. Within dermatologic surgery, one strategy is to close surgical incisions using percutaneous absorbable sutures. To the authors’ knowledge, there are no large studies comparing changes in suture preferences and subsequent outcomes during the pandemic. Objective To assess changes in suture preference and frequency of post-operative complications for percutaneous absorbable and non-absorbable sutures during the pandemic. Methods A retrospective review of 1358 Mohs surgeries completed at the Cleveland Clinic during a 2-month period prior to COVID-19 and a matched 2-month period during the pandemic. Results Sutures were used to close 1103 cases. Significantly more closures were performed with percutaneous absorbable sutures during COVID-19 (87.6%, 39.6%; P < .0001). There was no significant difference in the frequency of post-operative complications between suture materials ( P = .48). The use of absorbable sutures were associated with a significantly higher frequency of suture hypersensitivity reaction ( P = .020) but significantly lower frequency of infection ( P = .021) and wound dehiscence ( P < .0001). Conclusions Suture preference shifted towards absorbable sutures during the COVID-19 pandemic. Percutaneous absorbable sutures offered a formidable alternative to non-absorbable sutures and could reduce in-person follow-up visits without increasing post-operative complications.
What does it mean to flourish? Piloting the flourishing measure with adolescents and young adults with mood and anxiety disorders
Authors: Kelly-Hedrick Margot , Lhaksampa Tenzin C , Chisolm Margaret S , Miller Leslie 
Published: December 2022

Introduction: Treatment for adolescents and young adults with mood and anxiety disorders typically focuses on recovery of symptoms and improvement in functioning. Measuring positive states of health—using self-report surveys such as the Flourishing Measure—may help to promote holistic treatment. We piloted the Flourishing Measure—Adolescent Version in a clinical sample of adolescents and young adults with mood and/or anxiety disorders to determine appropriateness and acceptability in this population. Methods: We recruited adolescents (age 12–18) and young adults (age 19–25) with mood and/or anxiety disorders from an outpatient psychiatry clinic associated with an academic hospital. We used cognitive interviewing, a method used in survey development that determines whether respondents’ understanding aligns with instrument intention. Participants completed the Flourishing Measure and answered questions about their impressions of items. Results: Sixteen participants (10 adolescents and 6 young adults) participated in the study. Participants generally understood the concept of flourishing and the intention of individual items. The items were generally considered clear and participants offered minor suggestions for improvement in wording of the items. Discussion: Participants in our study understood the meaning of flourishing, as well as individual items in the measure. The Flourishing Measure may be suitable for use in clinical and research settings for adolescents and young adults, though piloting with larger, more diverse samples is needed.
Three woven structures of reduced graphene oxide conductive silk fabrics prepared by two different methods for electrical setting and sensing
Authors: Chen Kun , Xu Jingying , Zheng Yiqian , Li Jialin , Hong Xinghua 
Published: December 2022

Silk is widely used in flexible electronic equipment and intelligent textiles because of its well mechanical properties and bio-compatibility. Reduced graphene oxide is a two-dimensional carbon material with honeycomb lattice structure atoms and excellent electrical conductivity, which can give fabric a significant electrical conductivity. Herein, three types of RGO/Silk woven fabrics (satin, twill, and backed weaves) and two coating methods (screen printing and impregnating) were provided to explore the electrical properties, pressure sensing property and influence mechanism of silk surface characteristics. The results show the best preparation process of these two methods is five finishing times and 2 h reduction time. And the RGO/silk fabrics obtained by screen printing and impregnation have similar resistivity, but the RGO/silk fabrics obtained by screen printing provide better washing resistance. After nine washing cycles, the resistance of RGO/silk fabrics prepared by screen printing is 2 kΩ less than that obtained by impregnation. In addition, under the two methods, backed weave fabric shows the best conductivity, followed by twill and satin weave. Moreover, the RGO/Silk fabric sensor responds well to human motion, like finger bending and hand-holding objects. This work provides a train of thought and method for flexible conductive silk fabric.
Vessel wall imaging and quantitative flow assessment in arteriovenous malformations: A feasibility study
Authors: McGuire Laura Stone , Rizko Mark , Brunozzi Denise , Charbel Fady T , Alaraj Ali 
Published: December 2022

Introduction Cerebral arteriovenous malformations (AVMs) carry a rupture rate of 2–3% per year. Several architectural factors may influence rupture rate, and a recently theorized model of AVMs describes the influence of vessel wall inflammation. A novel imaging modality, vessel wall imaging (VWI), has been developed to view inflammatory processes in vessel wall foci but has not yet been examined in AVMs, which is the aim of this study. Methods This retrospective review studies prospectively collected data on patients with ruptured and unruptured AVMs between 2019 and 2021. Inclusion criteria included adult patients (≥18 years) with radiographically diagnosed AVM who underwent VWI. Charts were reviewed for medical history, clinical presentation, hospital course, discharge condition, and follow-up. Angioarchitectural features, blood flow, and VWI were compared in patients with and without hemorrhagic patients. Results Nine patients underwent VWI, mean age 37.7 ± 9.9 years. Four presented with hemorrhage (44.4%). Seven (77.7%) received glue embolization and 6 (66.7%) underwent surgical resection. All patients (4/4) with a history of hypertension presented with hemorrhage ( p = 0.0027). Size and Spetzler-Martin grade were not associated with hemorrhage ( p = 0.47, p = 0.59). Net AVM flow was higher in patients presenting with hemorrhage, although nonsignificant ( p = 0.19). With VWI, 3 (75%) hemorrhagic AVMs showed visible nidus and draining veins, and all three demonstrated positive post-contrast wall enhancement in at least one of their draining veins; conversely, of fivenonhemorrhagic AVMs, only 2 (40%) demonstrated post-contrast wall enhancement in any draining vein ( p = 0.090). Conclusion This pilot study successfully demonstrated capture of venous walls in AVMs using VWI. In this study, draining vein enhancement occurred more often in hemorrhagic AVM and in those with higher venous volumetric flow.
Midline submuscular penile prosthesis reservoir placement for patients with bilateral inaccessible inguinal rings: technique and outcomes
Authors: Zisman Ariel , Razdan Shirin , Siegal Alexandra , Sljivich Michaela , Bieber Christine , Ho Patrick , Valenzuela Robert 
Published: December 2022

Introduction: One of the most challenging aspects of inflatable penile prosthesis (IPP) surgery is reservoir placement. The traditional space of Retzius (SOR) is not suitable for all patients. For example, radical cystectomy or prostatectomy may alter the anatomical SOR. Hence, traditional placement of the reservoir in this space increases the risk of bowel or vascular injury. Also, patients with bilateral inguinal hernias repaired with mesh, or those with previous reservoirs that have been retained, are not eligible for a Retzius reservoir. Our study reports on the use of midline sub-rectus muscle placement of a penile prosthesis reservoir in these patients as an alternative to high submuscular placement commonly used. Methods: A retrospective chart review of male patients who underwent IPP surgery between June 2017 and 2021 was conducted. Patients were divided into two groups based on the location of the reservoir: SOR versus Midline Submuscular Reservoir (MSMR). Complication rates were compared, including herniated reservoirs, infections, bowel injuries, and vascular injuries. Results: Our cohort included 461 patients who underwent IPP surgery between June 2017 and 2021 in one tertiary center. SOR was used in 89% of patients and MSMR in 11% of patients ( n = 413 and 48, respectively). Median follow-up for all patients was 28 months. The mean age was 67 ± 8 years. There was no statistically significant difference between the two groups regarding age or comorbidities (BMI, diabetes mellitus, hypertension, hyperlipidemia, and coronary artery disease). The complication rate was low in both the SOR and MSMR groups, with device malfunction being the most common (2% versus 4%, respectively; p = 0.32). The infection rate was 0.5% in the SOR group with no infections in the MSMR group (NS). There was only one case of herniation requiring surgical revision in the SOR group and no cases of bowel or vascular injury. Conclusion: Placement of a penile prosthesis reservoir within a midline rectus submuscular space is a safe and effective technique when the SOR is compromised by previous surgery or bilateral inguinal canals are not accessible.
Tumor glycolytic profiling through 18F-FDG PET/CT predicts immune checkpoint inhibitor efficacy in advanced NSCLC
Authors: Silva Saulo Brito , Wanderley Carlos Wagner S. , Gomes Marin José Flavio , Macedo Mariana Petaccia de , do Nascimento Ellen Caroline Toledo , Antonacio Fernanda Frozoni , Figueiredo Caroline Sales , Trinconi Cunha Mateus , Cunha Fernando Q. , Castro Junior Gilberto de 
Published: December 2022

Background: A significant proportion of patients with non-small-cell lung cancer (NSCLC) do not respond to immune checkpoint inhibitors (ICIs). Since metabolic reprogramming with increased glycolysis is a hallmark of cancer and is involved in immune evasion, we used 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) to evaluate the baseline glycolytic parameters of patients with advanced NSCLC submitted to ICIs, and assessed their predictive value. Methods: 18F-FDG PET/CT results in the 3 months before ICIs treatment were included. Maximum standardized uptake values, whole metabolic tumor volume (wMTV), and whole-body total lesion glycolysis (wTLG) were evaluated. Cutoff values for high or low glycolytic categories were determined using receiver-operating characteristic curves. Progression-free survival (PFS) and overall survival (OS) were evaluated. Patients with a complete response and a matching group with resistance to ICIs underwent immunohistochemistry analysis. An unsupervised k-means clustering model integrating programmed cell death ligand 1 (PD-L1) expression, glycolytic parameters, and ICIs therapy was performed. Results: In all, 98 patients were included. Lower baseline 18F-FDG PET/CT parameters were associated with responses to ICIs. Patients with low wMTV or wTLG had improved PFS and OS. High wTLG, strong tumor expression of glucose transporter-1, and lack of responses were significantly associated. Patients with low glycolytic parameters benefited from ICIs, regardless of chemotherapy. Conversely, those with high parameters benefited from the addition of chemotherapy. Patients with higher wTLG and lower PD-L1 were associated with progression and worse survival to ICIs monotherapy. Conclusions: Glycolytic metabolic profiles established through baseline 18F-FDG PET/CT are useful biomarkers for evaluating ICI therapy in advanced NSCLC.
Fatal Post COVID mRNA-Vaccine Associated Cerebral Ischemia
Authors: McMillan Nadia , Rosenberg Harry J. , Anderson Matthew P. , Pal Pankaj , Stephenson Kathryn , Fehnel Corey R. 
Published: December 2022

Background Venous thromboses have been linked to several COVID-19 vaccines, but there is limited information on the Moderna vaccine’s effect on the risk of arterial thrombosis. Here we describe a case of post-Moderna COVID-19 vaccination arterial infarct with vaccine-associated diffuse cortical edema that was complicated by refractory intracranial hypertension. Case Summary 24 hrs after receiving her first dose of the Moderna COVID-19 vaccine, a 30-year-old female developed severe headache. Three weeks later she was admitted with subacute headache and confusion. Imaging initially showed scattered cortical thrombosis with an elevated opening pressure on lumbar puncture. An external ventricular drain was placed, but she continued to have elevated intracranial pressure. Ultimately, she required a hemicraniectomy, but intractable cerebral edema resulted in her death. Pathology was consistent with thrombosis and associated inflammatory response. Conclusion Though correlational, her medical team surmised that the mRNA vaccine may have contributed to this presentation. The side effects of COVID-19 infection and vaccination are still incompletely understood. Though complications are rare, clinicians should be aware of presentations like this one.
Early Mobilization Post Acute Stroke Thrombolysis and/or Thrombectomy Survey
Authors: Silver Brian , Demers-Peel Meaghan , Alexandrov Anne W. , Selim Magdy H. , Bernhardt Julie 
Published: December 2022

Background We sought to determine mobilization practices following emergency stroke therapy in centers across the United States. Methods We surveyed hospitals in the NIH StrokeNet regarding mobilization practices following acute stroke thrombolysis and/or thrombectomy. An anonymous survey was sent out to all StrokeNet sites Survey questions included stroke center designation, location of admission, whether a formal bed rest protocol was in place, minimum bed rest period required, which person first mobilized the patient. Results 48 centers responded to the survey including 45 Comprehensive Stroke Centers and 3 Primary Stroke Centers. Most patients were admitted to a neuro-intensive care unit (54%), others to a general medical/surgical ICU, stroke ward, or combination. 60% of respondents indicated that a formal bed rest policy was in place. Minimum bed rest requirements after thrombolysis alone ranged from 0 to 24 hours (35% with a 24-hour bed rest protocol, 19% with no minimum, 13% with a 12-hour minimum, 4% with an 8-hour minimum, 4% with a 6-hour minimum, and 6% with a variable rest period). Similar variations were reported in patients undergoing thrombectomy with ranges from 0 to 24 hours bed rest. First mobilization was by a nurse 52% of the time and by a physical therapist 48% of the time. Conclusions Mobilization practices following emergency ischemic stroke reperfusion treatments vary significantly across stroke centers. Mobilization of patients is performed primarily by nurses and therapists. Further study regarding an optimal approach for mobilization following acute ischemic stroke thrombolysis and/or thrombectomy is warranted.
Giant Cell Arteritis Presenting With Multiple Cranial Neuropathies – Case Report
Authors: Ye Jessica J. , Bouffard Marc A. , Brooks Earllondra , Hung Yin P. , Kimchi Eyal Y. 
Published: December 2022

Background: Vision loss accounts for most ophthalmic presentations of giant cell arteritis (GCA), but an important minority of patients present with diplopia and other cranial neuropathies. Case study: Here we present the case of an 84-year-old woman with a prior history of multiple cancers who was admitted to our hospital after developing double vision. She was found to have mydriasis, ptosis, and ophthalmoplegia in the right eye (OD) consistent with a combined R CNIII/CNVI neuropathy, as well as highly elevated inflammatory markers. Given her cancer history, the patient was initially worked up for various neoplastic, paraneoplastic, inflammatory, and infectious causes of multiple cranial neuropathies; however, as these results were negative, GCA became a more likely contender as a possible rare cause of multiple cranial neuropathies. The patient underwent temporal artery biopsy which showed pathology consistent with giant cell arteritis, and she was treated with steroids with eventual improvement in ophthalmoplegia and ptosis. Conclusions: This case illustrates the importance of recognizing GCA as a rare possible cause of multiple cranial neuropathies, including the indispensable role of temporal artery biopsy.
Caregiving for older people living with chronic pain: analysis of the English longitudinal study of ageing and health survey for England
Authors: Smith Toby , Mansfield Michael , Hanson Sarah , Welsh Allie , Khoury Reema , Clark Allan , Dures Emma , Adams Jo 
Published: December 2022

Background Chronic pain is a disabling condition. Many people with chronic pain seek informal support for everyday activities of daily living (ADL). However, there remains uncertainty on the type of people with chronic pain who access this support, what types of support they need and who provides such support. The purpose of this analysis was to answer these uncertainties. Methods Data from the Health Survey for England (HSE) and English Longitudinal Study of Ageing (ELSA) were accessed. People who reported chronic pain (moderate or above for minimum of 12 months) were identified. From these cohorts, we determined if individuals self-reported receiving informal care. Data on caregiver profiles and caregiving activities were reported through descriptive statistics. Logistic regression analyses were performed to compare health status outcomes between people with pain who received and who did not receive informal care. Results 2178 people with chronic pain from the ELSA cohort and 571 from the HSE cohort were analysed. People who received care were frequently female, older aged with several medical morbidities including musculoskeletal diseases such as arthritis. People with chronic pain received informal care for several diverse tasks. Most frequently these related to instrumental activities of daily living (IADL) such as shopping and housework. They were most frequently provided by partners or their children. Although they reported greater disability and symptoms ( p < 0.001), people who received care did not report differences in health status, loneliness or wellbeing ( p = 0.27; p = 0.46). Conclusions Whilst it may be possible to characterise people living in chronic pain who receive informal care, there is some uncertainty on the impact of informal caregiving on their health and wellbeing. Consideration should now be made on how best to support both care recipients and informal caregivers, to ensure their health and quality of life is promoted whilst living with chronic pain.
Sero-prevalence and associated factors of hepatitis B virus among pregnant women in Hawassa city public hospitals, Southern Ethiopia: Cross-sectional study design
Authors: Kassaw Birku , Abera Netsanet , Legesse Tegene , Workineh Alemu , Ambaw Gizachew 
Published: December 2022

Objective: This study aimed to determine the prevalence and identify associated factors of hepatitis B virus infection among pregnant women attending antenatal care (ANC) follow-up. Methods: An institution-based cross-sectional study was conducted from March 04 to April 03, 2020. A total of 381 women were selected using systematic random sampling after every two consecutive women. Structured and interviewer administered questionnaire was used to collect the data. A 2 ml of venous blood sample was drawn from each participant. The plasma was separated from the collected blood samples and was analyzed using a rapid hepatitis B surface antigen (HBsAg) kit to determine hepatitis sero status. Data were entered into the EPI-Data version 3.1, then exported to the statistical package for social sciences version 25 software and analyzed. Multivariable logistic regression was performed to identify independent predictors of HBsAg B seroprevalence at a p-value <0.05. Results: The prevalence of HBsAg sero-positivity among pregnant women was 6.6%, 95% CI (4.2, 8.9). History of hosptal admission (adjusted odds ratio (AOR) = 4.11; 95% CI = 1.33–12.71), surgical history (AOR = 6.8; 95% CI = 1.93–23.93), history dental procedures (AOR = 4.93; 95% CI = 1.31–18.53), and body tatoo practices (AOR = 6.822; 95% CI = 1.89–24.69) were found to be associated with HBsAg sero-positivity. Conclusion: This study found that HBsAg sero positivity among pregnant women in the study area was in intermediate edemicity. Factors such as history of hospital admission, history of surgery, history of dental procedures, and body tattoo practices were found to be associated with HBsAg sero-positivity. The government of Ethiopia should strengthen screening of all pregnant women for HBV as a part of routine ANC in ANC clinics and treating if they are positive to prevent mother to child transmission.
Satisfaction with comprehensive emergency obstetric and newborn care services and associated factors among clients in University of Gondar Specialized Hospital, Northwest Ethiopia: A cross-sectional study
Authors: Tiruneh Misganaw Guadie , Kebede Adane , Geberu Demiss Mulatu , Feleke Sefineh Fenta 
Published: December 2022

Objective: Emergency obstetric and newborn care services treat 70–80% of maternal deaths. This study aimed to assess satisfaction with comprehensive emergency obstetric and newborn care (CEmONC) services and associated factors among clients in the University of Gondar Specialized Hospital. Methods: Institution-based cross-sectional study was conducted on 404 participants using a systematic random sampling method. The study was conducted from March 5 to May 5, 2020, using interviewer-administered structured questionnaires. Binary logistic regression was used to find the association between independent variables and client satisfaction. The level of statistical significance was declared at a p value less than 0.05. Results: The overall clients’ satisfaction with CEmONC services was 65.1% (95% confidence interval (CI): 60.9–69.8). Clients’ satisfaction was affected by women who had antenatal care (ANC) of three visits (adjusted odds ratio (AOR): 6.5; 95%, CI: 2.04–20.8), women waited less than 15 min (AOR: 4.15, 95% CI: 1.9–9.06), mothers stayed ⩽1 day (AOR: 0.28, 95% CI: 0.09–0.9) and 2–3 days (AOR: 0.98, 95% CI: 0.1–0.69), obtaining a welcoming environment (AOR: 4.6, 95% CI: 2.15–9.88), and getting providers explanation of examinations (AOR: 3.3, 95% CI: 1.97–5.52). Conclusion: The observed clients’ satisfaction with CEmONC services was suboptimal. Having ANC of three visits, waiting less than 15 min, duration of stay, obtaining a welcoming environment, and an explanation of providers’ examination were the identified factors of client’s satisfaction. Therefore, hospital managers and health professionals should work on the identified factors to increase the client’s satisfaction with these services.