bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of gulf war toxic exposures after mild traumatic brain injury
Authors: Ferguson Scott , McCartan Robyn , Browning Mackenzie , Hahn-Townsend Coral , Gratkowski Arissa , Morin Alexander , Abdullah Laila , Ait-Ghezala Ghania , Ojo Joseph , Sullivan Kimberly , Mullan Michael , Crawford Fiona , Mouzon Benoit 
Published: October 2022

AbstractChemical and pharmaceutical exposures have been associated with the development of Gulf War Illness (GWI), but how these factors interact with the pathophysiology of traumatic brain injury (TBI) remains an area of study that has received little attention thus far. We studied the effects of pyridostigmine bromide (an anti-nerve agent) and permethrin (a pesticide) exposure in a mouse model of repetitive mild TBI (r-mTBI), with 5 impacts over a 9-day period, followed by Gulf War (GW) toxicant exposure for 10 days beginning 30 days after the last head injury. We then assessed the chronic behavioral and pathological sequelae 5 months after GW agent exposure. We observed that r-mTBI and GWI cumulatively affect the spatial memory of mice in the Barnes maze and result in a shift of search strategies employed by r-mTBI/GW exposed mice. GW exposure also produced anxiety-like behavior in sham animals, but r-mTBI produced disinhibition in both the vehicle and GW treated mice. Pathologically, GW exposure worsened r-mTBI dependent axonal degeneration and neuroinflammation, increased oligodendrocyte cell counts, and increased r-mTBI dependent phosphorylated tau, which was found to colocalize with oligodendrocytes in the corpus callosum. These results suggest that GW exposures may worsen TBI-related deficits. Veterans with a history of both GW chemical exposures as well as TBI may be at higher risk for worse symptoms and outcomes. Subsequent exposure to various toxic substances can influence the chronic nature of mTBI and should be considered as an etiological factor influencing mTBI recovery.
Pharmacophore study, molecular docking and molecular dynamic simulation of virgin coconut oil derivatives as anti-inflammatory agent against COX-2
Authors: Jack Kho Swen , Asaruddin Mohd Razip Bin , Bhawani Showkat Ahmad 
Published: October 2022

AbstractBackgroundVirgin coconut oil is mostly made up of saturated fatty acids in which approximately 72% are medium chain triglycerides. Medium chain triglycerides can be digested into medium chain fatty acids and medium chain monoglycerides which are bioactive components. Therefore, it is very important to study the in-silico ability of some Virgin coconut oil derivatives, namely, medium chain fatty acids and medium chain monoglycerides to inhibit Cyclooxygenase 2 (COX-2) protein for prevention of excessive inflammatory response.ResultsPharmacophore study displayed monolaurin with two hydrogen bond donor, three hydrogen bond acceptor and five hydrophobic interactions, while lauric acid presented two hydrogen bond acceptor, five hydrophobic interactions and a negative ion interaction. Molecular docking underlined the ability of monolaurin in the inhibition of COX-2 protein which causes inflammatory action with a decent result of energy binding affinity of − 7.58 kcal/mol and 15 interactions out of which 3 are strong hydrogen bond with TYR385 (3.00 Å), PHE529 (2.77 Å), and GLY533 (3.10 Å) residues of the protein. Monolaurin was employed as hydrogen bond acceptor to the side of residue TYR385 of COX-2 protein with an occupancy of 67.03% and was observed to be long-living during the entire 1000 frames of the molecular dynamic simulation. The analysis of RMSD score of the Monolaurin–COX-2 complex backbone was calculated to be low (1.137$$\pm$$±0.153 Å) and was in a stable range of 0.480 to 1.520 Å. Redocking of this complex still maintained a strong hydrogen bond (2.87 Å) with the main residue TYR385. AMDET results where promising for medium chain fatty acids and medium chain monoglycerides with good physicochemical drug scores.ConclusionsThis can be concluded from the results obtained that the monolaurin has strong interactions with COX-2 protein to disrupt its function due to significant hydrogen bonds and hydrophobic interactions with amino acid residues present in the target protein’s active site. These results displayed a very significant anti-inflammatory potential of monolaurin and a new promising drug candidates as anti-inflammatory agent.Graphical Abstract
An analysis of cultural dissemination and national image construction in Chinese influencer Li Ziqi’s vlogs and its impact on international viewer perceptions on YouTube
Authors: Whyke Thomas William , Chen Zhen Troy , Lopez-Mugica Joaquin 
Published: October 2022

AbstractInternational social exchanges have always been important to China’s cultural soft power and image construction overseas. This study focuses on an internationally renowned mega influencer Li Ziqi and her vlogs on YouTube. These orchestrated vlogs tell stories of rural Chinese life and construct a desirable traditional Chinese rural culture for netizens at home and abroad. Informed by framing and cultivation theory, this study examines how user-generated content on national images can affect social media users’ perceptions of reality. Content analysis is used to analyze the visual portrayals of Chinese rural culture, including its customs and values, aesthetics, and cultural and scenic places in Li’s vlogs. Discourse analysis is further used to examine user comments and demonstrate her vlog content’s impact on user perceptions of Chinese rural culture. This study sheds light on how a complex and hybrid national image with ‘Chineseness,’ and a personal image with self-Orientalized and performed ‘soft but independent’ Chinese rural female image, is constructed by a social media influencer Li Ziqi with affective associations. At a conceptual and practical level, the findings of this study contribute to the ongoing scholarly discussions on how China engages with the globalized world through cultural diplomacy from the bottom-up, while existing research primarily takes a top-down approach.
Massive duodenal ulcer bleeding due to the ruptured hepatic artery pseudoaneurysm after living donor liver transplantation
Authors: Kadohisa Masashi , Inomata Yukihiro , Sakisaka Masataka , Sugawara Yasuhiko , Hibi Taizo 
Published: October 2022

Abstract
Background
The rupture of a hepatic artery pseudoaneurysm (HAP) is a rare but lethal complication after living donor liver transplantation (LDLT) and often manifests as acute gastrointestinal bleeding.

Case presentation
This report describes three patients who experienced HAP after LDLT. These patients initially presented with active bleeding of a duodenal ulcer (DU) in the duodenal bulb, followed by diagnosis of the ruptured HAP by angiography. None of the patients had evidence of an active intra-abdominal infection or bile leakage preceding the rupture of HAP. All patients were initially treated by transcatheter arterial coil embolization (TAE). In all cases, TAE was successful for hemostasis but resulted in complete obstruction of the arterial inflow to the graft. Arterial revascularization by surgical reconstruction using the autologous arterial graft in one case and re-LDLT in another one was successfully performed. The other one succumbed to sepsis caused by later liver abscesses.

Conclusion
This is the first detailed case series of massive DU bleeding as a warning signal of ruptured HAP after LDLT. HAP should be included in the differential diagnosis when an LDLT recipient presents with gastrointestinal bleeding.
Implantable micro-scale LED device guided photodynamic therapy to potentiate antitumor immunity with mild visible light
Authors: Choi Jiwoong , Lee Il Seong , Lee Ju Seung , Jeon Sangmin , Yun Wan Su , Yang Suah , Moon Yujeong , Kim Jinseong , Kim Jeongrae , Choy Seunghwan , Jeong Chanho , Shim Man Kyu , Kim Tae-il , Kim Kwangmeyung 
Published: October 2022

Abstract

Background
Photodynamic therapy (PDT) is a promising strategy to promote antitumor immunity by inducing immunogenic cell death (ICD) in tumor cells. However, practical PDT uses an intense visible light owing to the shallow penetration depth of the light, resulting in immunosuppression at the tumor tissues.

Methods
Herein, we propose an implantable micro-scale light-emitting diode device (micro-LED) guided PDT that enables the on-demand light activation of photosensitizers deep in the body to potentiate antitumor immunity with mild visible light.

Results
The micro-LED is prepared by stacking one to four micro-scale LEDs (100 μm) on a needle-shape photonic device, which can be directly implanted into the core part of the tumor tissue. The photonic device with four LEDs efficiently elicits sufficient light output powers without thermal degradation and promotes reactive oxygen species (ROS) from a photosensitizer (verteporfin; VPF). After the intravenous injection of VPF in colon tumor-bearing mice, the tumor tissues are irradiated with optimal light intensity using an implanted micro-LED. While tumor tissues under intense visible light causes immunosuppression by severe inflammatory responses and regulatory T cell activation, mild visible light elicits potent ICD in tumor cells, which promotes dendritic cell (DC) maturation and T cell activation. The enhanced therapeutic efficacy and antitumor immunity by micro-LED guided PDT with mild visible light are assessed in colon tumor models. Finally, micro-LED guided PDT in combination with immune checkpoint blockade leads to 100% complete tumor regression and also establishes systemic immunological memory to prevent the recurrence of tumors.

Conclusion
Collectively, this study demonstrates that micro-LED guided PDT with mild visible light is a promising strategy for cancer immunotherapy.
Defining the Current Landscape, Attitudes, and Perceived Barriers of Virtual Medicine in Underserved Populations
Authors: Hundal Jasmin , Bade Katarina , Hsu Emily , Chhabra Jyoti , Menendez Alvaro 
Published: October 2022

PURPOSE: Virtual medicine (VM) use increased during the COVID-19 pandemic as it represented a safe alternative to traditional face-to-face health care delivery. This prospective cross-sectional study aimed to characterize preferences and perceived barriers to VM on the basis of language and specific sociodemographic variables while also identifying particular subpopulations at risk of dissatisfaction regarding VM. METHODS: An institutional review board–approved, 23-item questionnaire was offered in English and Spanish. Examined variables included demographic information, preferences, and perceived barriers regarding VM. Multivariable analysis was performed to determine the association between demographic variables and participants' preferences and perceived barriers. RESULTS: Fewer Hispanic and underserved patients (N = 241) had received oncological care through VM (28.9% v 30.8%) despite comparable preferences and levels of satisfaction regarding the incorporation of VM in health care delivery (21.6% v 25.4%; 68.7% v 82.1%), respectively, with no significant difference by age, level of education, marital status, or Hispanic ethnicity, although Spanish as primary language was statistically significant ( P = .001). Although Hispanic and underserved rely more on social media to receive health information (26.5% v 24.7%), they have more technical barriers. They were up to 2.9 times more likely not to have a phone/iPad/similar or access broadband connectivity. CONCLUSION: Given the shift toward outpatient and home-based care, an aging population, and cultural appropriations, VM excitedly allows the reincorporation of family/caregiver in medical engagement. Hispanic patients are equally interested and satisfied in receiving oncological care through VM, but fewer are currently using it. Barriers are predominantly technical and targetable with appropriate policies to help overcome technological barriers on the basis of language, ethnic, locoregional, and sociodemographic variables.
Concurrent Administration of Immune Checkpoint Inhibitors and Stereotactic Radiosurgery Is Well-Tolerated in Patients With Melanoma Brain Metastases: An International Multicenter Study of 203 Patients
Authors: Lehrer Eric J. , Gurewitz Jason , Bernstein Kenneth , Kondziolka Douglas , Fakhoury Kareem R. , Rusthoven Chad G. , Niranjan Ajay , Wei Zhishuo , Lunsford L. Dade , Malouff Timothy D. , Ruiz-Garcia Henry , Peterson Jennifer L. , Bonney Phillip , Hwang Lindsay , Yu Cheng , Zada Gabriel , Deibert Christopher P. , Prasad Rahul N. , Raval Raju R. , Palmer Joshua D. , Patel Samir , Picozzi Piero , Franzini Andrea , Attuati Luca , Mathieu David , Trudel Claire , Lee Cheng-chia , Yang Huai-che , Jones Brianna M. , Green Sheryl , Ahluwalia Manmeet S. , Sheehan Jason P. , Trifiletti Daniel M. 
Published: October 2022

BACKGROUND:
Melanoma brain metastases are commonly treated with stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs). However, the toxicity of these 2 treatments is largely unknown when administered concurrently.

OBJECTIVE:
To evaluate the risk of radiation necrosis (RN) with concurrent and nonconcurrent SRS and ICIs.

METHODS:
The guidelines from the Strengthening the Reporting of Observational Studies in Epidemiology checklist were used. Inverse probability of treatment weighting, univariable and multivariable logistic regression, and the Kaplan-Meier method was utilized.

RESULTS:
There were 203 patients with 1388 brain metastases across 11 international institutions in 4 countries with a median follow-up of 15.6 months. The rates of symptomatic RN were 9.4% and 8.2% in the concurrent and nonconcurrent groups, respectively (P =.766). On multivariable logistic regression, V12 ≥ 10 cm3 (odds ratio [OR]: 2.76; P =.006) and presence of BRAF mutation (OR: 2.20; P =.040) were associated with an increased risk of developing symptomatic RN; the use of concurrent over nonconcurrent therapy was not associated with an increased risk (OR: 1.06; P =.877). There were 20 grade 3 toxic events reported, and no grade 4 events reported. One patient experienced a grade 5 intracranial hemorrhage. The median overall survival was 36.1 and 19.8 months for the concurrent and nonconcurrent groups (log-rank P =.051), respectively.

CONCLUSION:
Concurrent administration of ICIs and SRS are not associated with an increased risk of RN. Tumors harboring BRAF mutation, or perhaps prior exposure to targeted agents, may increase this risk. Radiosurgical optimization to maintain V12 < 10 cm3 is a potential strategy to reduce the risk of RN.
Prognosis of Rotational Angiography-Based Stereotactic Radiosurgery for Dural Arteriovenous Fistulas: A Retrospective Analysis
Authors: Shinya Yuki , Hasegawa Hirotaka , Kawashima Mariko , Koizumi Satoshi , Katano Atsuto , Umekawa Motoyuki , Saito Nobuhito 
Published: October 2022

BACKGROUND:
Cerebral dural arteriovenous fistulas (DAVFs) are intracranial vascular malformations with fine, abnormal vascular architecture. High-resolution vascular imaging is vital for their visualization. Currently, rotational angiography (RA) provides the finest 3-dimensional visualization of the arteriovenous shunt with high spatial resolution; however, the efficacies of the integration of RA have never been studied in stereotactic radiosurgery (SRS) for DAVFs until now. Since 2015, our institution has integrated RA into SRS (RA-SRS) to provide more conformal planning, thereby decreasing overtreatment and undertreatment.

OBJECTIVE:
To analyze the outcomes of RA-SRS for DAVFs.

METHODS:
We retrospectively analyzed the outcomes of 51 patients with DAVFs and compared those of 20 DAVFs treated with RA-SRS with those of 31 DAVFs treated with conventional SRS (c-SRS).

RESULTS:
The time to obliteration was shorter in the RA-SRS group (median, 15 months vs 26 months [cumulative rate, 77% vs 33% at 2 years, 77% vs 64% at 4 years]; P = .015). Multivariate Cox proportional hazards analysis demonstrated that RA-SRS (hazard ratio 2.39, 95% CI 1.13-5.05; P = .022) and the absence of cortical venous reflux (hazard ratio 2.12, 95% CI 1.06-4.25; P = .034) were significantly associated with obliteration. The cumulative 5-year post-SRS stroke-free survival rates were 95% and 97% in the RA-SRS and c-SRS groups, respectively (P = .615). Neurological improvement tended to occur earlier in the RA-SRS group than in the c-SRS group (median time to improvement, 5 months vs 20 months, log-rank test; P = .077).

CONCLUSION:
RA-based SRS may facilitate earlier fistula obliteration and may contribute to early neurological improvement.
Once upon a dish: the next frontier in engineering multicellular systems
Authors: Huch Meritxell , Gouti Mina 
Published: October 2022

ABSTRACT
In June 2022, the second meeting on ‘Engineering Multicellular Systems’, organized by the European Molecular Biology Laboratory and the Institute of Bioengineering of Catalonia, took place in Barcelona. Stem cell and systems biologists, physicists and engineers from all over the world gathered to discuss how recent breakthroughs in organoid technologies, engineering and mechanobiology are boosting our understanding of early morphogenesis, organogenesis and organ function with applications in tissue engineering, disease modeling and drug screening. The meeting was organized with sustainability in mind, and included an ethics session and an outreach public activity.
Progression of the pluripotent epiblast depends upon the NMD factor UPF2
Authors: Chousal Jennifer N. , Sohni Abhishek , Vitting-Seerup Kristoffer , Cho Kyucheol , Kim Matthew , Tan Kun , Porse Bo , Wilkinson Miles F. , Cook-Andersen Heidi 
Published: October 2022

ABSTRACT
Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that degrades RNAs harboring in-frame stop codons in specific contexts. Loss of NMD factors leads to embryonic lethality in organisms spanning the phylogenetic scale, but the mechanism remains unknown. Here, we report that the core NMD factor, UPF2, is required for expansion of epiblast cells within the inner cell mass of mice in vivo. We identify NMD target mRNAs in mouse blastocysts – both canonical and alternatively processed mRNAs – including those encoding cell cycle arrest and apoptosis factors, raising the possibility that NMD is essential for embryonic cell proliferation and survival. In support, the inner cell mass of Upf2-null blastocysts rapidly regresses with outgrowth and is incompetent for embryonic stem cell derivation in vitro. In addition, we uncovered concordant temporal- and lineage-specific regulation of NMD factors and mRNA targets, indicative of a shift in NMD magnitude during peri-implantation development. Together, our results reveal developmental and molecular functions of the NMD pathway in the early embryo.
The Cancer Hub Approach for Upper Gastrointestinal Surgery During COVID-19 Pandemic: Outcomes from a UK Cancer Centre
Authors: Doyle Joseph P. , Patel Pranav H. , Doran Sophie L. F. , Jiao Long R. , Cunningham David , Nicol David , Mavroeidis Vasileios K. , Allum William H. , Chaudry Asif M. , Bhogal Ricky H. , Kumar Sacheen 
Published: October 2022

Abstract
Background
The coronavirus disease 2019 (COVID-19) pandemic caused unprecedented disruption to global healthcare delivery. In England, the majority of elective surgery was postponed or cancelled to increase intensive care capacity. Our unit instituted the ‘RM Partners Cancer Hub’ at the Royal Marsden Hospital in London, to deliver ongoing cancer surgery in a ‘COVID-lite’ setting. This article describes the operational set-up and outcomes for upper gastrointestinal (UGI) cancer resections performed during this period.

Methods
From April 2020 to April 2021, the Royal Marsden Hospital formed the RM Partners Cancer Hub. This approach was designed to coordinate resources and provide as much oncological treatment as feasible for patients across the RM Partners West London Cancer Alliance. A UGI surgical case prioritisation strategy, along with strict infection control pathways and pre-operative screening protocols, was adopted.

Results
A total of 231 patients underwent surgery for confirmed or suspected UGI cancer during the RM Partners Cancer Hub, with 213 completed resections and combined 90-day mortality rate of 3.5%. Good short-term survival outcomes were demonstrated with 2-year disease free survival (DFS) and overall survival (OS) for oesophageal (70.8% and 72.9%), gastric (66.7% and 83.3%) and pancreatic cancer resections (68.0% and 88.0%). One patient who developed perioperative COVID-19 during the RM Partners Cancer Hub operation made a full recovery with no lasting clinical sequelae.

Conclusion
Our experience demonstrates that the RM Partners Cancer Hub approach is a safe strategy for continuing upper gastrointestinal (GI) resectional surgery during future periods of healthcare service disruption
Beating the Algorithm: Consumer Manipulation, Personalized Pricing, and Big Data Management
Authors: Li Xi , Li Krista J. 
Published: October 2022

Problem definition: Firms heavily invest in big data technologies to collect consumer data and infer consumer preferences for price discrimination. However, consumers can use technological devices to manipulate their data and fool firms to obtain better deals. We examine how a firm invests in collecting consumer data and makes pricing decisions and whether it should disclose its scope of data collection to consumers who can manipulate their data. Methodology/results: We develop a game-theoretic model to consider a market in which a firm caters to consumers with heterogeneous preferences for a product. The firm collects consumer data to identify their types and issue an individualized price, whereas consumers can incur a cost to manipulate data and mimic the other type. We find that when the firm does not disclose its scope of data collection to consumers, it collects more consumer data. When the firm discloses its scope of data collection, it reduces data collection even when collecting more data is costless. The optimal scope of data collection increases when it is more costly for consumers to manipulate data but decreases when consumer demand becomes more heterogeneous. Moreover, a lower cost for consumers to manipulate data can be detrimental to both the firm and consumers. Lastly, disclosure of data collection scope increases firm profit, consumer surplus, and social welfare. Managerial implications: Our findings suggest that a firm should adjust its scope of data collection and prices based on whether the firm discloses the data collection scope, consumers’ manipulation cost, and demand heterogeneity. Public policies should require firms to disclose their data collection scope to increase consumer surplus and social welfare. Even without such a mandatory disclosure policy, firms should voluntarily disclose their data collection scope to increase profit. Moreover, public educational programs that train consumers to manipulate their data or raise their awareness of manipulation tools can ultimately hurt consumers and firms. Funding: X. Li acknowledges financial support from the Hong Kong Research Grants Council [Grant 21500920]. K. J. Li acknowledges financial support from the Weimer Faculty Fellowship. Supplemental Material: The Online Appendix is available at https://doi.org/10.1287/msom.2022.1153 .