bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression
Authors: Grotehans Nils , McGarry Lynn , Nolte Hendrik , Kroker Moritz , Narbona-Pérez Álvaro Jesús , Deshwal Soni , Giavalisco Patrick , Langer Thomas , MacVicar Thomas 
Published: November 2022

AbstractReplication and expression of the mitochondrial genome depend on the sufficient supply of nucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental to mitochondrial genomes and can result in instability of mitochondrial DNA and inflammation. Here, we report that a mitochondrial nucleoside diphosphate kinase, NME6, supplies mitochondria with ribonucleotides to drive the transcription of mitochondrial genes. Moreover, NME6 supports the maintenance of mitochondrial DNA when the access to cytosolic deoxyribonucleotides is limited. Perturbation of NME6 leads to the depletion of mitochondrial transcripts, destabilisation of the electron transport chain and impaired oxidative phosphorylation; deficiencies which are suppressed upon supplementation with pyrimidine ribonucleotides. Our work proposes NME6 and mitochondrial nucleotide metabolism to be untapped therapeutic targets in diseases associated with aberrant mitochondrial gene expression including cancer and autoimmune disorders.
AMPK activation restores salivary function following radiation treatment
Authors: Meyer Rachel , Gilman Kristy , Rheinheimer Brenna A. , Meeks Lauren , Limesand Kirsten H. 
Published: November 2022

AbstractHead and neck cancers represent a significant portion of cancer diagnoses, with head and neck cancer incidence increasing in some parts of the world. Typical treatment of early-stage head and neck cancers includes either surgery or radiotherapy; however, advanced cases often require surgery followed by radiation and chemotherapy. Salivary gland damage following radiotherapy leads to severe and chronic hypofunction with decreased salivary output, xerostomia, impaired ability to chew and swallow, increased risk of developing oral mucositis, and malnutrition. There is currently no standard of care for radiation-induced salivary gland dysfunction and treatment is often limited to palliative treatment that provides only temporary relief. AMP-activated protein kinase (AMPK) is an enzyme that activates catabolic processes and has been shown to influence the cell cycle, proliferation, and autophagy. In the present study, we found that radiation (IR) treatment decreases tissue levels of phosphorylated AMPK following radiation and decreases intracellular NAD+ and AMP while increasing intracellular ATP. Further, expression of Sirtuin-1 (SIRT1) and nicotinamide phosphoribosyl transferase (NAMPT) were lower five days following IR. Treatment with AMPK activators, AICAR and metformin, attenuated compensatory proliferation (days 6, 7 and 30) following IR, and reversed chronic (day 30) salivary gland dysfunction post-IR. Additionally, treatment with metformin or AICAR increased markers of apical/basolateral polarity (phosphorylated aPKCζT560 positive area) and differentiation (amylase positive area) within irradiated parotid glands to levels similar to untreated controls. Taken together, these data suggest that AMPK may be a novel therapeutic target for treatment of radiation-induced salivary damage.
Virus-like particle displaying SARS-CoV-2 receptor binding domain elicits neutralizing antibodies and is protective in a challenge model
Authors: McKechnie Julia L. , Fiala Brooke , Wolf Clancey , Ellis Daniel , Holtzman Douglas , Feldhaus Andrew 
Published: November 2022

AbstractWhile the effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has largely been successful, particularly in the developed world, the rise of new variants as well as waning immunity illustrate the need for a new generation of vaccines that provide broader and/or more durable protection against infection and severe disease. Here we describe the generation and characterization of IVX-411, a computationally designed, two-component virus-like particle (VLP) displaying the ancestral SARS-CoV-2 receptor binding domain (RBD) on its surface. Immunization of mice with IVX-411 generates neutralizing antibodies against the ancestral strain as well as three variants of concern. Neutralizing antibody titers elicited by IVX-411 are durable and significantly higher than those elicited by immunization with soluble RBD and spike antigens. Furthermore, immunization with IVX-411 is shown to be protective in a Syrian Golden hamster challenge model using two different strains of SARS-CoV-2. Overall, these studies demonstrate that IVX-411 is highly immunogenic and capable of eliciting broad, protective immunity.
IFNγ and acute prenatal infection withToxoplasma gondiiactivate fetal hematopoietic stem cells
Authors: López Diego A. , Otsuka Kelly S. , Apostol April C. , Posada Jasmine , Sánchez-Arcila Juan C. , Jensen Kirk D.C. , Beaudin Anna E. 
Published: November 2022

AbstractInfection directly influences adult hematopoietic stem cell (HSC) function and differentiation, but much less is known about the fetal hematopoietic response to infection during pregnancy. Here, we investigated the fetal hematopoietic response to maternal infection withToxoplasma gondii(T. gondii), an intracellular parasite that elicits Type II IFNγ-mediated maternal immunity. The effects of maternal IFNγ on developing HSCs and the signals that mediate these interactions have not been investigated. Our investigation reveals that the fetal HSCs respond toT. gondiiinfection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. We demonstrate that maternal IFNγ crosses the fetal-maternal interface and is perceived by fetal HSCs. By comparing the effects of maternal IFNγ injection with maternalT. gondiiinfection, our observations reveal that IFNγ mimics aspects of the fetal HSC response to infection. Moreover, our data disentangle the role of infection-induced inflammatory cytokines in driving the expansion of downstream hematopoietic progenitors. Our findings illuminate that the fetal HSC response to prenatal infection is distinct from the adult HSC response to IFNγ-induced inflammation.
In silico study on evaluation of corosolic acid of Lagerstroemia speciosa against Alzheimer’s disease
Authors: Venkateswarulu T.C , Vajiha  , Krupanidhi S. , Mikkili Indira , Angelina Jacinth , John Babu D. , Peele K. Abraham 
Published: November 2022

PurposeAlzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative disorder caused by the aggregation of amyloid-beta (Aβ) at outside of neuron cells and also due to tau aggregation inside the cell. Corosolic acid is aimed to be selected as a main active constituent of Lagerstroemia speciosa for the study.Design/methodology/approachIn the present study, molecular docking of corosolic acid and tau protein was examined using PyRx-v.0.8 software. Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties were described and a molecular dynamics study of the bound complex was performed using Desmond.FindingsThe docking score and interactions suggested that the corosolic acid (CID:6918774) could bind to tau protein to prevent the fibrillar network, to prevent AD. During simulation corosolic acid-bound protein root mean square deviation (RMSD) values showed more stability when compared to the Apo form of protein. Molecular dynamics study of tau protein and corosolic acid complex gave the insights to develop a drug-like candidate against AD.Originality/valueThe use of corosolic acid of Lagerstroemia speciosa to prevent AD is supported by preliminary analysis on a computational basis. This compound should explore in terms of experimental strategies for the further drug development process. However, in vitro and in vivo evaluation studies are required to suggest the use of corosolic acid against AD.
Nonadditive tourism forecast combination using grey relational analysis
Authors: Hu Yi-Chung 
Published: November 2022

PurposeForecasting tourism demand accurately can help private and public sector formulate strategic planning. Combining forecasting is feasible to improving the forecasting accuracy. This paper aims to apply multiple attribute decision-making (MADM) methods to develop new combination forecasting methods.Design/methodology/approachGrey relational analysis (GRA) is applied to assess weights for individual constituents, and the Choquet fuzzy integral is employed to nonlinearly synthesize individual forecasts from single grey models, which are not required to follow any statistical property, into a composite forecast.FindingsThe empirical results indicate that the proposed method shows the superiority in mean accuracy over the other combination methods considered.Practical implicationsFor tourism practitioners who have no experience of using grey prediction, the proposed methods can help them avoid the risk of forecasting failure arising from wrong selection of one single grey model. The experimental results demonstrated the high applicability of the proposed nonadditive combination method for tourism demand forecasting.Originality/valueBy treating both weight assessment and forecast combination as MADM problems in the tourism context, this research investigates the incorporation of MADM methods into combination forecasting by developing weighting schemes with GRA and nonadditive forecast combination with the fuzzy integral.
Towards a comprehensive perspective to making learning a part of life: a response to Fischer et al.'s contribution
Authors: Looi Chee-Kit 
Published: November 2022

PurposeThis response paper aims to comment on specific aspects of the position paper.Design/methodology/approachIn this paper, the author presents a response to Fischer et al.'s contribution on “The Challenge for the Digital Age: Making Learning a Part of Life.” While imperatives and narratives of learning in the future have been well articulated in the literature, their paper provides insights into lifelong learning in the digital age.FindingsThe author raises comments on the comprehensiveness of the lifelong learning perspectives and the calls to action. Over the years, with multiyear efforts on the research-based evolution of the design, implementation and adoption of technology-supported learning environments in some parts of the world, the author believes well-researched innovative pedagogy and design principles have already to some extent impacted transformation of learning and teaching in normal schools. By referring to the work in the running of a model school in Taiwan, the author demonstrate some of the pathways that can guide innovation and work towards operationalizing a futuristic vision that is resonant with the one painted in the paper. The paper will end with some comments on how narratives on the future of learning will evolve.Originality/valueIn trying to understand the lens that the vision would bring to learning on the digital edge, the author has provided commentaries to probe into the comprehensiveness of their vision of future learning. From an Asian perspective, the author describes one effort that can help make progress in moving towards this vision. It involves realizing the vision by grounding our designs in real experiments or instantiations, such as the interest-driven creator (IDC) experimental school in Taiwan, and highlight past research efforts which have been successful in transformation of classrooms and schools such as developing seamless learning for connecting learning in different spaces afforded by mobile digital devices.
Measuring physicians’ religious competence in clinical health communication context: female Muslim immigrant patients’ expectations
Authors: Ahmed Rukhsana , Mao Yuping 
Published: November 2022

Purpose
This exploratory study aims to examine female Muslim immigrant patients’ expectations of physicians’ religious competence during clinical interactions.

Design/methodology/approach
In total, 101 female Muslim immigrants in Ottawa, Canada, completed an eight-item survey measuring patients’ expectations of physicians’ religious competence during clinical communication.

Findings
Results from the independent samples t-tests and one-way ANOVA suggested that female Muslim immigrant patients in this study expected their doctors to be aware of Islam as a religion and be sensitive to their religious needs, especially food/dietary practices during clinical communication. Although the participants did not differ in their expectations of physicians’ religious competence based on age, educational level, employment status and income level, they differed based on their frequencies of visiting doctors and their ethnic/cultural origin.

Originality/value
This study fills a gap in the literature by advancing understanding of religious competence during clinical interactions from female Muslim immigrant patients’ perspective. The findings can contribute to developing religiously competent and accessible health-care services for religiously diverse populations.
SMART-QUAL: a dashboard for quality measurement in higher education institutions
Authors: Adot Esther , Akhmedova Anna , Alvelos Helena , Barbosa-Pereira Sofia , Berbegal-Mirabent Jasmina , Cardoso Sónia , Domingues Pedro , Franceschini Fiorenzo , Gil-Doménech Dolors , Machado Ricardo , Maisano Domenico Augusto , Marimon Frederic , Mas-Machuca Marta , Mastrogiacomo Luca , Melo Ana I. , Miguéis Vera , Rosa Maria J. , Sampaio Paulo , Torrents Dani , Xambre Ana Raquel 
Published: November 2022

PurposeThe paper aims to define a dashboard of indicators to assess the quality performance of higher education institutions (HEI). The instrument is termed SMART-QUAL.Design/methodology/approachTwo sources were used in order to explore potential indicators. In the first step, information disclosed in official websites or institutional documentation of 36 selected HEIs was analyzed. This first step also included in depth structured high managers’ interviews. A total of 223 indicators emerged. In a second step, recent specialized literature was revised searching for indicators, capturing additional 302 indicators.FindingsEach one of the 525 total indicators was classified according to some attributes and distributed into 94 intermediate groups. These groups feed a debugging, prioritization and selection process, which ended up in the SMART-QUAL instrument: a set of 56 key performance indicators, which are grouped in 15 standards, and, in turn, classified into the 3 HEI missions. A basic model and an extended model are also proposed.Originality/valueThe paper provides a useful measure of quality performance of HEIs, showing a holistic view to monitor HEI quality from three fundamental missions. This instrument might assist HEI managers for both assessing and benchmarking purposes. The paper ends with recommendations for university managers and public administration authorities.
Theoretical analysis of social inclusion and social leverage in the Anthropocene era
Authors: Reyes Ortiz Giovanni Efrain , Socorro Márquez Félix Oscar , Gassón Pacheco Rafael A. 
Published: November 2022

PurposeThe main objective of this research is to present a theoretical review of social inclusion and social leverage in the Anthropocene era.Design/methodology/approachTo fulfil this objective, four fundamental and complementary approaches are taken into account: (1) the theory of increasing capacities and increasing opportunities as essential aspects of Amartya Sen's theory of human development; (2) the perspective and factors of the current globalization process; (3) Douglass North's neo-institutionalist approach to social and political conditions and (4) the foundations of Jürgen Habermas's theory of legitimacy.FindingsThese considerations make possible a perspective that goes beyond the strictly economic elements, to complement the point of view with other aspects, including those of public policy analysis as part of the current era of global change known as Anthropocene.Research limitations/implicationsThe study is limited to a theoretical review of social inclusion and social leverage essentially taking into account the perspectives of Amartya Sen, Douglass North and Jürgen Habermas.Practical implicationsSocial leverage mechanisms can be efficient means to achieve conditions of sustained and inclusive improvements in the conditions of social interrelations. In this way, it is possible to shape dynamics of economic and social development, based on productive efficiency, social equity and ecological sustainability.Social implicationsThe fundamental contribution explained by this study consists in establishing that social leverage is essential in order to achieve three goals inherent to economic and social development.Originality/valueBased on its methodology and academic vision, the paper is completely original.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/IJSE-02-2022-0086
The hippogryphs on the 14th floor: the future of hybrid work
Authors: Hirsch Peter Buell 
Published: November 2022

Purpose
This study aims to examine how differing attitudes to flexible working pose new challenges to employers seeking to have workers return to the office.

Design/methodology/approach
This viewpoint reviews a range of opinion research studies to tease out points of tension and points of opportunity in how employers are handling flexing working postpandemic.

Findings
Analysis of the available research suggests that there are considerable disparities in the views of employers and employees, particularly white-collar workers on hybrid and flexible working. Based on these insights, this viewpoint suggests several ways in which employers will need to collaborate with workers to sustain robust corporate cultures and retain their best workers.

Originality/value
To the best of the author’s knowledge, there has been no comprehensive set of recommendations for how companies can handle the challenges they face in seeking to return their workers to centralized offices.
Reliving a traumatic experience through emotional creativity: the bright side of cancer during the COVID-19 pandemic
Authors: Rezaee Vessal Saeedeh , Partouche-Sebban Judith , Schiavone Francesco 
Published: November 2022

PurposeThe COVID-19 outbreak has undoubtedly affected overall mental health. Thus, researching resilience is important, as it has been previously discussed as a means to protect people from mental health problems. This study aims to clarify whether survivors of a traumatic event (i.e. cancer survivors) are more resilient to living through another traumatic experience, such as COVID-19, compared to those who have never had such an experience. The study also examines the role of emotional creativity in this process.Design/methodology/approachA quantitative research design was adopted. The data collection was performed through a survey (N = 338), which was conducted among two separate groups of participants. The first group (N = 152) included the survivors of a traumatic event (i.e. cancer survivors), and the second group (N = 186) included those who did not have such an experience.FindingsThe results demonstrate that living through a traumatic experience results in a higher level of resilience during another traumatic experience (i.e. COVID-19), which is the result of higher post-traumatic growth. Moreover, emotional creativity is discussed as an explanatory variable that explains a significantly higher level of post-traumatic growth among survivors of a traumatic event.Originality/valueThis research offers a better understanding of the effect of living through a traumatic event on post-traumatic growth and resilience in living through another traumatic experience. Moreover, post-traumatic growth is explained through emotional creativity improvement, which happens after experiencing a traumatic life event.
Teleworkers' job performance: a study examining the role of age as an important diversity component of companies' workforce
Authors: Hamouche Salima , Parent-Lamarche Annick 
Published: November 2022

PurposeTeleworking seems to be the new future of the workplace. It has been widely adopted during the COVID-19 crisis, which has greatly influenced work organization conditions. This pandemic and its accompanying changes represent significant challenges for employees' performance, depending on their age if the study considers the physical and psychological vulnerabilities of older employees and their assumed or expected difficulties to cope with the new information and communication technologies (ICTs). This study aims at examining the direct effects of teleworking, and age on job performance (in-role). As well as analyzing the moderating effect of age on the relationship between teleworking and in-role job performance in times of crisis.Design/methodology/approachData were collected in Canada from 18 companies, with a sample of 272 employees. Multivariate regression and moderation regression analyses were performed using Stata 13.FindingsResults revealed that when teleworking, older age is associated with lower job performance and younger age is associated with higher job performance. Conversely, when working on-site, older age is associated with higher job performance, whereas younger age is associated with lower job performance.Practical implicationsFrom a practical perspective, these results highlight the importance of decision authority and recognition. As well as the presence of age disparities related to work arrangements. Managers need to adopt an inclusive approach and develop work arrangements that take into consideration employees' needs and ages. Some insights and practical recommendations are presented in this paper to support managers and human resource practitioners.Originality/valueStudies examining the in-role job performance of teleworkers and the effects of age are sparse. This study helps to expand research on human resources management, job performance and age.
Smart city and spatial configuration: assessing accessibility and intelligibility to increase mobility in the George Town heritage site, Malaysia
Authors: Safizadeh Mina , Maghsoodi Tilaki Mohammad Javad , Hedayati Marzbali Massoomeh , Abdullah Aldrin 
Published: November 2022

PurposeThe emerging concept of smart city is known to aim at sustainable urban development. One of the requirements for a smart city is to address accessibility inequalities. This study aims to investigate the accessibility level issues in urban transformation before and after combining different street networks for Penang, Malaysia, as a case study to reveal greater insight and helpful information into mobility and accessibility inequalities for future smart city planning.Design/methodology/approachUsing DepthmapX software, two main quantitative methodologies of space syntax, namely, spatial integration accessibility (SIA) and angular segment analysis by metric distance (ASDMA), are employed to analyse the level of accessibility for the main streets of George Town site before and after combination with contemporary networks. Integration, choice and entropy values were calculated for the study analysis.FindingsResults revealed the implications of combining old irregular gridiron structures with the existing planned grid structures. George Town seems to have gained a higher capacity for pedestrian accessibility; however, vehicle accessibility has lost its capacity. Findings further suggest that a combination of irregular structure and grid structure is essential for urban growth in similar historical contexts to improve accessibility and address mobility inequalities.Originality/valueThe study concludes by highlighting the importance of the analysis of street structure transformation to predict consequences and promote the potential to reduce current inequalities in vehicle accessibility.