bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast milk as a topical eye drop reduces the severity of ROP: A randomized placebo-controlled trial.
Authors: Silahli Musa , Tekin Mehmet , Kal Ali , Gökmen Zeynel , Büyükeren Melek , Ozcan Beyza , Yılmaz Fatma , Yümlü Kadir , Torer Birgin , Çetinkaya Bilin 
Published: June 2022

Abstract
Objective
Retinopathy of prematurity (ROP) is the most common cause of visual impairment and disability in preterm infants. Human breast milk contains stem cells which have the ability to differentiate into all three germ layers. This study investigated whether breast milk used as an eye drop reduces severe ROP or laser-requiring ROP in VLBWinfants.
Methods
A single-blinded, multicenter, prospective, randomized controlled trial was conducted from May 2021 to December 2021 in four level 3 neonatal intensive care units in (hidden for reviewer) in preterm infants younger than 32 weeks gestation. Participants were randomly assigned to use either breast milk eye drops or a placebo (0.9% normal saline). The primary outcome was any stage of ROP. Secondary outcomes were laser-requiring ROP and the highest stage of ROP during follow-up.
Results
For the final analysis, a total of 62 participants (28.6 (2) weeks) were included in the breast milk group (BMG) and 39 participants (29.9 (2) weeks) were included in the placebo group (PG). Although risk factors for the development of ROP and advanced stage ROP were consolidated in BMG, treatment with breast milk reduced ROP progression in patients with ROP in the first examination (stage 2–3 ROP n = 9 (75%) in BMG vs. n = 3 (80%) in PG), RR = 0.93, 95% CI: [0.54–1.61]; p = 0.999). No serious adverse effects were observed in either group.
Conclusion
The use of freshly expressed breast milk as eye drops reduced the advanced stage of ROP or laser-required ROP in patients with ROP on initial examination.
Biochemical estimation of manganese nanoparticles reactions in native and model biological systems
Authors: Sieprawska Apolonia , Rudolphi-Szydło Elżbieta , Barbasz Anna , Skórka Magdalena , Telk Anna , Filek Maria 
Published: June 2022

Abstract
Purpose
Due to its physiological importance as a micronutrient, manganese supplementation requires taking into account the possibility of overdosing, which is associated with the initiation of stressogenic effects in plant cells. The use of nanoparticles may reduce the amount of Mn ion administered, especially during foliar treatment. Hence, the aim of the research was to demonstrate the mechanism of action of MnNPs on plant cells and to determine the extent of the stress-inducing reaction of these NPs.
Methods
A response to manganese nanoparticles was studied in seedlings of two wheat cultivars, model system of plant cell membranes and compared with cell lines (U-937, HL-60, HUT-78, COLO-720L). The nanoparticles (MnNPs as Mn3O4) were at the same concentrations (125 and 250 mg/mL) by foliar application to plants and to the cell culture media.
Results
The administration of NPs enhanced the content of Mn in plant cells, indicating its penetration through the leaf surface and initiated the oxidative stress measures as an increase in enzyme activity, starch accumulation, and a decrease in chlorophyll synthesis. Moreover, a rise in the electrokinetic potential of the chloroplast membrane surface and the reconstruction of their hydrophobic parts toward an increase in fatty acid saturation was found.
Conclusion
The study demonstrated that the stress response in plant cells was initiated up to 250 mg/mL of MnNPs. The same concentration resulted in reduction of cell viability, especially in U-937 line.
Brassinosteroids modulate the polyamines profile in enhancing resistance to manganese toxicity in Malus robusta Rehd.
Authors: Zhang Qing , Liang Meixia , Song Ruoxuan , Song Zhizhong , Song Hao , Qiao Xuqiang 
Published: June 2022

Abstract
Background and aims
Manganese (Mn) toxicity is a widely spread phenomenon in soils, seriously restricting crop growth, quality and yield. However, mechanisms towards BRs in regulating PAs-enhanced Mn stress are unknown. This study aims to explore the effects of BRs on Mn resistance of apple seedlings by regulating PAs profile.
Methods
The effects of 2,4-epibrassinolide (EBL) on the expression of genes involved in BR signal pathway, Mn accumulation, polyamines-mediated responses (precursors, content, metabolic enzymes and genes) as well as growth parameters in Mn-stressed Malus robusta Rehd. were assessed.
Results
EBL application significantly modulated BR signaling genes (MdBRI, MdBSK, etc.) expression and reduced Mn accumulation, accompanied with strengthened growth rate of root length and plant height, RWC, chlorophyll content, Fv/Fm, ΦPSII, and decreased electrical conductivity. Meanwhile, it weakened Orn pathway, decreased ODC activity and increased biosynthesis from Put to Spm via elevating the PAO activity and expressions of MdSPDS, MdSPMS and MdPAO. ADC and DAO activities and MdDAO gene expression failed to restrain the loss of Put. The trends for free, PS-conjugated and PIS-bound PAs were similar to that of total PAs, except that no significant change was observed in free Spm, PS-conjugated Spd and Spm as well as PIS-bound Spd groups. As a result, EBL significantly reduced Put accumulation and enhanced Spm content and (Spd + Spm)/Put ratio.
Conclusions
This study contributes to clarify the utility of BR-induced PAs response as an important mitigative measure against Mn toxicity in fruit trees.
Mechanism of Shen Shuai II Recipe against Renal Hypoxia in Chronic Kidney Disease: Based on Network Pharmacology and Molecular Docking Study
Authors: Xu Yizeng , Wang Meng , Wang Chen 
Published: June 2022

Abstract
Background
Renal hypoxia is prevalent in chronic kidney disease (CKD), and aggravates renal failure. Shen Shuai II Recipe (SSR) is our common herbal formula for the treatment of CKD. However, the molecular mechanism of SSR under the efficacy remains unclear. This study aims to systematically explore the potential mechanism of SSR in the improvement of renal hypoxia in CKD using network pharmacology prediction and molecular docking validation.
Methods
The bioactive compounds and targets of SSR were mined from TCMSP database and employed to construct compounds-targets network by Cytoscape 3.8.2. The corresponding targets reflecting CKD-associated renal hypoxia were retrieved from GeneCards, OMIM and DrugBank databases. The intersection of compound target and disease target was obtained and imported into STRING database to build a PPI network. Metascape was used for GO and KEGG pathway enrichment analyses on screened coincident targets. We further constructed compounds-targets-pathways network using Cytoscape 3.8.2, and the Autodock was adopted for molecular docking validation on the core active compounds and targets.
Results
A total of 145 active compounds and 249 targets of SSR were identified. Furthermore, 8 compounds and 10 targets were screened as the key roles in the therapeutic effect of SSR. GO and KEGG analysis showed that the mechanisms of SSR against renal hypoxia in CKD were closely related to the regulation of proliferation, differentiation, apoptosis, inflammation, and oxidative stress through AGE-RAGE, p53, JAK-STAT, HIF-1 as well as IL-1β/c-Myc signaling pathway. The molecular docking results indicated good binding activities of the predicted compounds with targets.
Conclusion
This study reveals the multi-compounds, multi-targets, and multi-pathways synergistic mechanism of SSR against CKD-associated renal hypoxia, which provides a reference for subsequent basic research of SSR in CKD treatment.
CFD analysis of a solar parabolic trough collector powered adsorption cooling system using nanofluid under Tunisia climate
Authors: Mhedheb Taysir , Jr Skander , Feidt Michel , Mhimid Abdallah 
Published: June 2022

Abstract
Energy requirements for cooling systems are growing every year, especially in regions with significant solar radiation intensity. This increase causes big electricity consumption and environmental pollution. Hence, using solar energy as a heat source instead electricity for cooling needs is considered as a promising way. In this study, a transient Computational Fluid Dynamics (CFD) simulation is carried out to investigate the performance of solar Parabolic Trough Collector (PTC) powered adsorption refrigeration system using nanofluid under a typical meteorological data of Tozeur, Sahara of Tunisia. The pure oil (Therminol-VP1) and Copper/Therminol-VP1 nanofluid (2% volumetric concentration) are the examined heat transfer fluids (HTF). The model is validated against data reported in the literature suggesting that the CFD approach can accurately predict the examined system. Specific Cooling Power (SCP), thermal system coefficient of performance (COPth) and solar Coefficient of Performance (COPs) were evaluated to assess the system performance. The results indicate that the system using thermal oil (VP1) operates satisfactorily under Tozeur climatic conditions achieving a SCP of 2.7W/kgz, a COPth around 0.378 and it could produce a daily useful cooling of 1920kJ, while the COPs could reach 0.06 for 8kg of Zeolite adsorbent. Furthermore, using a nanofluid of VP1 and nanoparticles of Cu as HTF enhancer increases the system performance by 10.58%.
An empirical study on Data Empowerment driving enterprise innovation performance in Shaanxi Province manufacturing enterprises
Authors: Zhao Wenping , Zhang wengong , Lv Jiaoqian 
Published: June 2022

Abstract
In the modern day, data resources have become the most important elements of production in the digital economy. However, manufacturing enterprises face the challenge of being unable to maximise the value of their data resources. This article presents a hypothetical model of the link between data empowerment (DE), network capability (NC), and enterprise innovation performance (EIP), based on the perspective of data empowerment (DE). On the basis of 245 data empowerment questionnaires from manufacturing enterprises in Shaanxi Province, the results indicate that data empowerment (DE) has a significant positive impact on the network capability (NC) and enterprise innovation performance (EIP). Network capability (NC) has a positive impact on enterprise innovation performance (EIP) and acts as a partial mediator between manufacturing enterprise data empowerment (DE) and innovation performance (EIP).
Assessing internalizing symptoms and their relation with levels of impairment: Evidence-based cutoffs for interpreting Inventory for Depression and Anxiety Symptoms (IDAS-II) scores
Authors: Rosa-Caceres Ana De la , Lozano Oscar M. , Sanchez-Garcia Manuel , Fernandez-Calderon Fermin , Rossi Gina , Diaz-Batanero Carmen 
Published: June 2022

Abstract
Background
Tests and scales measuring psychological disorders should provide information about how scores relate to other constructs such as quality of life or functional impairment. Such information is necessary to allow that their scores contribute to clinical decision making. The current study analyzes the clinical utility of the Inventory for Depression and Anxiety Symptoms (IDAS-II) to discriminate between different levels of functional impairment and identify the IDAS-II scales that contribute most to explaining impairment
Methods
The total sample (N = 1390) consists of two subsamples: a community sample of the general population (n = 1072) selected by random sampling; and a sample of patients (n = 318) from public and private mental health services. The IDAS-II for measuring internalizing symptoms and WHODAS 2.0 for measuring impairment were administered to all participants.
Results
All scales show statistically significant higher scores in the patient sample, with Cohen's d effect sizes values greater than 0.30, except for well-being (d = 0.19). The cutoff values and their confidence intervals do not overlap with the means of either the community or patient sample. AUC values for most of the scales are above .70, except for appetite gain, ordering, euphoria, cleaning, and well-being. Multiple linear regression model using IDAS-II scales explain 57.1% of the variance of the WHODAS 2.0 (F 12.1377 = 155.305; p < .001).
Conclusions
Cutoff values provided allow us to reliably differentiate between the patients and community samples. IDAS-II scores show greater sensitivity and specificity in detecting those with greater impairment. General Depression, Lassitude, Panic and Claustrophobia contribute to impairment in a greater extent. Knowledge of which symptoms are most related with impairment, allows healthcare providers to improve treatment planning based on empirical evidence.
Air Jet Impingement Cooling for Hot-Stamping Dies
Authors: Chen Li-wei , Dat Dong Van 
Published: June 2022

Abstract
The strength of panel sheets can be increased by 2-3 times after hot stamping, and for high quality of hot stamped sheets, uniform cooling rate on the die face to quench the panel is needed. However, it is difficult for cooling water channels, commonly used for hot stamping dies, to dissipate heat evenly. In addition, dies are easily corroded by contact with water at high temperature. Thus, this study considers air cooling for the quenching process. The air flow can be applied to the sheet directly during the forming stage to cool and quench, eliminating difficulties with cooling channel design and providing more uniform cooling. Simulations and experiments were used to test the feasibility of air cooling for hot-stamping with CSC-15B22 steel. A simple hot stamping tool with flat die face and either water or air cooling channels was used for testing, and results show that the both direct and indirect air flow can be used for hot stamping. With indirect air cooling, the cooling rate is sufficient for complete martensite transition, though the cooling rate is 40% lower than with indirect water cooling. To improve cooling efficiency of the air cooling system and obtain more uniform cooling, an air jet impingement cooling system (direct air flow cooling) was also tested. Results show that a similar cooling rate can be obtained in both indirect water cooling and the air jet impingement cooling. Thus, it is possible for air jet impingement cooling to provide hot stamping superior to water cooling. These results can be a reference for the design of new cooling systems for hot stamping dies.
Does T1 slope minus cervical lordosis mismatch affect surgical outcomes of cervical laminoplasty in the absence of preoperative severe kyphosis?
Authors: Sakamoto Ryuji , Nakamoto Hideki , Yoshida Yuichi , Ohtomo Nozomu , Nagata Kosei , Kato So , Doi Toru , Matsubayashi Yoshitaka , Taniguchi Yuki , Tanaka Sakae , Oshima Yasushi 
Published: June 2022

Abstract
Background: The impact of the T1 slope minus cervical lordosis (T1S-CL) on surgical outcomes in patients with degenerative cervical myelopathy undergoing laminoplasty (LP) was assessed.Methods: One hundred patients who underwent cervical LP were retrospectively reviewed. Radiographic measurements included C2–C7 lordosis (CL), T1 slope (T1S), and C2–C7 sagittal vertical axis (SVA). Additionally, pain numeric rating scale, neck disability index (NDI), 12-Item Short-Form Health Survey, Euro QOL 5 dimensions (EQ5D), and Japanese Orthopedic Association score were investigated. According to past reports, T1S–CL > 20° was defined as mismatched. Then, based on T1S-CL mismatching, patients were divided into 2 groups.Results: This research understudied 67 males and 33 females with a mean age of 67 y. Preoperatively, only eight patients showed a T1S-CL mismatch. Besides, while the C2–7 Cobb angles did not change significantly after surgery, the T1 slope (T1S) angle increased, increasing the T1S-CL. Furthermore, no significant differences between the two groups were observed in clinical outcomes based on the preoperative T1S-CL mismatch. However, the number of patients in the mismatched group increased to 21 patients postoperatively. Additionally, since we compared clinical outcomes based on the postoperative T1S-CL, results showed a significantly worse postoperative NDI score and preop/postop EQ5D scores in the mismatched group.Conclusions: Although cervical LP showed inferior outcomes in patients with postoperative T1S-CL even in the absence of severe preoperative kyphosis (>10°), preoperative T1S-CL mismatch was not adversely prognostic.
Lifeworld perspectives of people with dementia: A meta-aggregation of qualitative studies
Authors: Eriksen Siren , Engedal Knut , Grov Ellen Karine 
Published: June 2022

Abstract
Objectives: This meta-aggregation aims to interpret and synthesize the lifeworld perspectives of people with dementia and develop a model for guidance in clinical practice. Method: The data consist of four meta-syntheses describing different lifeworld perspectives in accordance with van Manen’s existentials: lived relations, lived space, lived time and lived body. The meta-aggregation summarizes a range of views expressed by people with dementia in qualitative, interview-based studies, with the aim of generating a reliable model based on the studies’ findings.Results: In total, 88 studies among 1,191 persons with dementia were included. Sixteen areas of focus were found, representing four perspectives: (a) lived relations, consisting of connectedness, independence, equality and competence; (b) lived space, consisting of belonging, meaningfulness, safety and security, and autonomy; (c) lived time, consisting of being rooted in the past, being in the present, viewing the future and being in process; and (d) lived body, consisting of being functional, trustworthy, adaptable and presentable. A model shaped as a tree trunk captures the lifeworld perspectives of people with dementia. Conclusion: Sixteen areas were revealed from this meta-aggregation and form the basis of a model. This model may be used as a guide for health care personnel to ensure lifeworld-preserving care with a person-centred approach for people with dementia.
Nucleated red blood cells are predictive of in-hospital mortality for pediatric patients
Authors: Gearhart Addison , Esteso Paul , Sperotto Francesca , Elia Eleni G. , Michelson Kenneth A. , Lipsitz Stuart , Sun Mingwei , Knoll Christopher , Vanderpluym Christina 
Published: June 2022

Abstract
Purpose: We sought to establish whether nucleated red blood cells (NRBCs) are predictive of disposition, morbidity, and mortality for pediatric patients presenting to the emergency department (ED).Methods: A single center retrospective cohort study examining all ED encounters from patients<19 years old between January 2016 and March 2020, during which a CBC was obtained. Univariate analysis and multivariable logistic regression were used to test presence of NRBCs as independent predictor of patient-related outcomes.Results: The prevalence of NRBCs was 8.9% (4,195/46,991 patient encounters). Patient with NRBCs were younger (median age 4.58 vs 8.23 years; P<0.001). Those with NRBCs had higher rates of in-hospital mortality (30/2,465 [1.22%] vs 65/21,741 [0.30%]; P<0.001), sepsis (19% vs 12%; P<0.001), shock (7% vs 4%; P<0.001), and CPR (0.62% vs 0.09%; P<0.001). They were more likely to be admitted (59% vs 51%; P<0.001), have longer median hospital length of stay (LOS) (1.3 [IQR: 0.22, 4.14] vs. 0.8 days [0.23, 2.64]; P<0.001), and median intensive care unit (ICU) LOS (3.9 [IQR: 1.87, 8.72] vs 2.6 days [IQR: 1.27, 5.83]; P<0.001). Multivariable regression revealed presence of NRBCs as an independent predictor for in-hospital mortality (adjusted odds ratio (aOR) 2.21 95% CI 1.38-3.53; p<0.001), ICU admission (aOR 1.30 95% CI 1.11, 1.51), CPR (aOR 3.83 95% CI 2.33-6.30; p<0.001), and 30-day return to the ED (aOR 1.15 95% CI 1.15-1.26; P<0.001).Conclusions: Presence of NRBCs is an independent predictor for mortality, including in-hospital mortality, ICU admission, CPR, and readmission within 30 days for children presenting to the ED.
The Cognitive Functions and Seizure Outcomes of Patients with Low-Grade Epilepsy-Associated Neuroepithelial Tumors
Authors: Xie Mingguo , Qiao Jiao , Wang Xiongfei , Zhou Jian , Guan Yuguang , Liu Changqing , Zhao Meng , Li Tianfu , Luan Guoming 
Published: June 2022

Abstract
Purpose
The aim of the study was to evaluate the cognitive functions and seizure outcomes of patients with low-grade epilepsy-associated neuroepithelial tumors (LEATs).
Methods
We retrospectively reviewed the clinical data of patients who underwent preoperative neuropsychological evaluations and subsequent epilepsy surgery for LEATs. The neuropsychological results of full-scaled intelligence quotient (FSIQ) and full-scaled memory quotient (FSMQ) were analyzed, as well as the postoperative seizure outcomes.
Results
Of the 138 patients included in the study, 59 patients (40.4%) were female and 47 (36.6%) patients were children. Preoperatively, 138 patients received FSIQ assessments and 30 patients (21.7%) had an intellectual deficit (FSIQ < 80 scores); 124 patients received FSMQ assessments and 32 patients (25.8%) had a memory deficit (FSMQ < 80 scores). Younger age at seizure onset (OR = 0.93; P = 0.035) and discordant ictal electroencephalography (EEG) findings (OR = 5.26; P = 0.001) were found to predict intellectual deficits, while abnormal hippocampus (OR = 2.36; P = 0.051) as well as discordant ictal EEG findings (OR = 4.03; P = 0.007) tended to cause memory deficits. During postoperative follow-up, 123 patients (90.7%) were followed up at least 12 months, and among them, 105 patients (85.4%) got seizure-free (Engel class I), while 18 patients (14.6%) were not (Engel class II-IV); longer duration of epilepsy (OR = 1.01; P < 0.001) and discordant interictal EEG findings (OR = 5.91; P = 0.005) were found to be related to poor seizure outcomes in patients with LEATs.
Conclusion
Cognitive deficits commonly occur in patients with LEATs, especially in patients with early or childhood seizures. Early surgical intervention, however, could prevent most of patients from repeated seizure onsets and thus cognitive impairments.
Low serum iodine is associated with iodine deficiency and thyroid dysfunctions: a cross-sectional study
Authors: 徐 婷婷 , Guo Wenxing , Ren Zhiyuan , Wei Hongyan , Tan Long , Zhang Wanqi 
Published: June 2022

Abstract
Background The relationship between low serum iodine and thyroid dysfunctions in adults is not well understood. This study aimed to explore the relationship between serum and urinary iodine and thyroid dysfunctions in the adult population. Methods: A total of 1320 participants were included in the final analysis. We collected basic demographic information, as well as blood and spot urine samples, to determine serological indices and iodine nutritional status of subjects. Results: The median (IQR) serum iodine (SI) level was 70.5µg/L (59.6–83.6µg/L). Compared to those with 59.6µg/L ≤ SI < 83.6µg/L, subjects with SI ≤ 59.6µg/L had a higher risk of thyroid dysfunctions (OR = 1.72, 95%CI: 1.08–2.75), clinical hypothyroidism (OR = 16.4, 95%CI: 3.72–72.2) and sUIC < 100µg/L (OR = 1.41, 95%CI: 1.05–2.00). The areas under the ROC curve of SI (0.554, P = 0.02) was significantly higher than that of sUIC/UCr (0.446, P = 0.005). Conclusions: Serum iodine is more sensitive than urine iodine in the diagnosis of thyroid dysfunctions. Low serum iodine concentration is associated with an increased risk of thyroid dysfunctions, especially hypothyroidism.