bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clofarabine and Total Body Irradiation (TBI) as Conditioning Regimen for Allogeneic Stem Cell Transplantation in High-Risk Acute Leukemia Patients.
Authors: Cheikh Jean El , bidaoui ghassan , Atoui Ali , terro khodr , sharrouf layal , Zahreddine Ammar , moukalled nour , abudalle imane , Bazarbachi Ali , Mohty Mohamad , Dulery Remy 
Published: November 2022

Abstract
Background: Clofarabine (Clo) is an immunosuppressive purine analog that may have better anti-leukemic activity than fludarabine (Flu) in the conditioning regimen for allogeneic stem cell transplant (allo-SCT) for acute leukemia patients. The addition of total body irradiation (TBI) to conditioning regimens has been widely investigated. However, the use of single agent Clo in combination with intermediate doses of TBI ranging from 4-8 Gy has not been studied yet.
Objective: This study aims to identify the outcome of patients with high-risk hematological malignancies who underwent allo-SCT from different donor types and received Clo and TBI (4-8 Gy) as a conditioning regimen.
Methods: This is a double center, observational, retrospective study of patients with high-risk hematological malignancies diagnosed from 2012 to 2021, treated at the American University of Beirut Medical Center in Beirut (AUBMC), Lebanon, and Saint-Antoine Hospital (SA) in Paris, France. Data regarding patient baseline characteristics, disease-related factors, and transplant outcomes including graft-versus-host disease (GVHD), Non-relapse mortality (NRM), progression-free survival (PFS), and overall survival (OS), were collected.
Results: We identified 24 high-risk patients with a median age at transplant of 37 years (range 22-78). Of these, 15 patients (63%) were males, 8 patients (33%) had acute myeloid leukemia (AML), 3 patients (13%) had myelodysplastic syndrome (MDS), and 12 patients (50%) had acute lymphoblastic leukemia (ALL), and 1 patient had B-lymphoblastic lymphoma (B-ALL) (4%). At the time of the transplant, only 15 patients (63%) were in complete remission (CR). Nine patients (38%) received transplants from a matched related donor(MRD), 9 patients (38%) from a haploidentical related donor(haplo), 4 patients (17%) from a matched unrelated donor(MUD), and 2 patients (8%) from an unrelated cord blood donor (UCB). All patients received Clo. For TBI, 21 patients (88%) received a total dose of 4 Gy, and 3 (12%) received 8 Gy. Sixteen patients (67%) received anti-thymocyte globulin(ATG). After a median follow-up of 40 months, the cumulative incidences of grade II-III acute GVHD, grade IV acute GVHD, and chronic GVHD were 50%, 4%, and 8%, respectively. NRM at 100 days, and 1 year after transplant was 4% and 25%, respectively. 17% of the patients had a relapse or progression of the disease by the end of the study. The 2-year PFS and OS were 50% and 56%, respectively. The median PFS and OS were not reached.
Conclusions: Clo/TBI (4-8 Gy) as a conditioning regimen for allo-SCT in high-risk patients confers disease control with an acceptable toxicity profile.
Hydrogen-controlled structural reconstruction of palladium-bismuth oxide cluster to single atom alloy for low-temperature CO Oxidation
Authors: Nan Bing , Li Lulu , Li Yunan , Guo lingling , Du Meng , Liu Zhengwu , Tao Xin , Tian Chen , Liang Zhenye , Zhang Yanxing , Ma Chao , Shen Lu , Si Rui , Li Lina 
Published: November 2022

Abstract
Palladium (Pd) has been widely regarded as a high-performance catalyst for various oxidative reactions, however, the actual structure of active site remains controversial due to structural evolution under operation conditions. Herein, we prepared a series of bismuth (Bi)-doped silica-supported Pd catalysts and found a hydrogen-controlled structural reconstruction mechanism of palladium-bismuth oxide cluster to single atom alloy to efficiently catalyze low-temperature CO oxidation. The formation of PdxBiyOz clusters with unique Pd−O−Bi coordination structure could enhance the sinter-resistance ability of Pd species. This structural evolution of active site is clearly uncovered by in-situ XAFS results, in which metallic Bi−Pd shell gradually generates as the increase of reduction temperature without any metallic Bi−Bi bond. More importantly, PdBi1 single atom alloy exhibits an excellent CO oxidation activity with a high CO2 production rate of 413 µmolCO2·gPd−1·s− 1 at 100°C and excellent catalytic stability. Density function calculation (DFT) results indicate that there are geometric and electronic effects between Bi and Pd atoms, which favor total linear-CO adsorption, activate CO and O2 molecules, and reduce the barrier for the formation of OO-CO intermediates in PdBi1 single atom alloy.
Dose-related Adaptive Reconstruction of DMN in isoflurane Administration: a Study in the Rat
Authors: Guo Fengru , Li Yuqin , Jian Zhaoxin , Cui Yan , Gong Wenhui , Li Airui , Jing Wei , Xu Peng , Chen Ke , Guo Daqing , Yao Dezhong , Xia Yang 
Published: November 2022

Abstract

The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Herein, we implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data. The results showed that adaptive reconstruction were induced by isoflurane, exhibiting reduced static and stable long-range FC, altered topological features. These reconstruction patterns were in a dose-related fashion and delta-band dominated. These results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN.
Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice
Authors: Yang Jun , You Jia , Ma Ming-Yue , Liu Huan , Chen Jia-Yi , Cao Xi-Yuan , Aimaier Reyihanguli , Li Hao-Ran , Zibibula Xieyidai , Zhao He-Ping , Yang Yi , Zhao Hui-Xin 
Published: November 2022

Abstract
Our previous study reported that the metabolite of Bacillus subtilis BS-Z15 n-butanol site could reduce body weight gain in mice, showing anti-obesity effects. This study further demonstrated the effects of purified mycosubtilin on the body weight gain and gut microbiota of Kunming mice. 30 male Kunming white mice were randomly selected into three groups at four weeks of age: Control (group A), gavage-administered with saline daily; n-butanol site treated (group B), gavage-administered with n-butanol site metabolites (90 mg/kg); and mycosubtilin treated (group C), gavage-administered with mycosubtilin (6 mg/kg). Different groups' gut microbiota compositions were analyzed using high-throughput sequencing technology. The results showed that the effects of mycosubtilin and n-butanol sites were consistent; the treatment groups showed a significant reduction in body weight gain as well as triglyceride and low-density lipoprotein contents as compared to the control group (P < 0.05). Moreover, the size and contents of epididymal adipocytes were also significantly reduced (P < 0.05), and the gavage administration of mycosubtilin could significantly increase the expression levels of lipolysis gene adipose triglyceride lipase (ATGL) in the mice liver. Mycosubtilin and n-butanol site treatments could significantly alter the composition of the gut microbiota as compared to the physiologic saline treatment. B. subtilis BS-Z15 metabolites may regulate weight gain primarily by mycosubtilin, according to these findings. The mycosubtilin might reduce weight gain in mice by regulating lipid metabolism, thereby reducing fat accumulation and altering the composition of gut microbiota.
Development and application of a data processing method for food metabolomics analysis
Authors: Lei Yuanluo , Chen Xiaoying , Shi Jiachen , Liu Yuanfa , Xu Yong-Jiang 
Published: November 2022

Abstract
Food metabolomics is described as the implementation of metabolomics to food systems such as food materials, food processing, and food nutrition. These applications generally create large amounts of data, and although while the technology exists to analyze this data and different tools exist in various ecosystems, downstream analysis is still a challenge and the tools are not integrated into a single method. In this article, we developed a data processing method for untargeted LC-MS data in metabolomics, derived from the integration of computational MS tools from OpenMS into workflow system Konstanz Information Miner (KNIME). This method can analyze raw MS data and produce high-quality visualizations. A MS1 spectra-based identification, two MS2 spectra-based identification workflows and a GNPSExport-GNPS workflow were included in this method. As compared with conventional approaches, combining the result of MS1&MS2 spectra-based identification workflow via the tolerance of retention time and mass to charge ratio (m/z), which can greatly reduce the rate of false positives in metabolomics datasets. In our example, filtering with the tolerance removed more than 50% of the possible identifications while keeping 90% of the correct identification. The result demonstrated that the developed method is rapid and reliable method for food metabolomics data processing.
Optical properties and structural features of UV-C irradiated polyvinylidene chloride films
Authors: B Akkamma M. , Lobo Blaise 
Published: November 2022

Abstract
The modifications caused in polyvinylidene chloride (PVDC) polymer films on exposure to ultra-violet light (UV-C light of wavelength 254 nm) in air for different exposure times varying from one hour up to six hours have been investigated by using ultraviolet - visible (UV-Vis) and Fourier transform infrared (FTIR) spectroscopic techniques, as well as powder X-ray diffraction (XRD) technique. XRD scans reveal that the degree of crystallinity (Xc) increased from 4.7% up to 28.6% on increasing the UV exposure time of PVDC from 1 hour up to 4 hours, and a further increase in the exposure time causes a decrease in the value of Xc. The FTIR scans reveal the formation of hydrogen bonded hydroxyl groups as well as conjugated alkene structures in the PVDC sample on exposure to UV-C radiation. For the study of modification in band structure of the UV irradiated PVDC films, the UV-Vis spectroscopy was used; it was found that the optical band gap decreases from 4.70 eV down to 3.92 eV, as obtained from the plot of √εi hν versus hν, using linear fit method and the penetration depth (δ) decreased from 0.0074 cm down to 0.0035 cm at 4.88eV, the energy corresponding to UV-C radiation. The calculation of percentage decrease in the value of δ with respect to wavelength and UV-C exposure time reveals that UV-C irradiated PVDC films are good radiation shields against both UV-A and UV-B EM radiation. The study of refractive index with respect to wavelength reveals that UV irradiation of PVDC films is an effective method to modify the refractive index of PVDC, thereby making the material suitable for use in different optical applications. The optical dielectric constant was studied systematically, which demonstrates that the energy storage properties of the PVDC films can be tuned and tailored by UV-C radiation. Details are discussed.
Obesity and sex- and age-specific income – evidence from the HUNT study
Authors: Edwards Christina , Bjørngaard Johan H. , Kinge Jonas 
Published: November 2022

Abstract
Background
Elevated body mass index (BMI) has been found to be associated with lower income, especially among women, and increasing evidence suggests that this association is causal. However, there is limited knowledge about the sex-specific effect of BMI on income at different ages. The relationship between BMI and income may change with age due to, for example, BMI-related morbidities or discrimination. The aim of this study was to investigate the sex-specific causal link between BMI and income at different ages.
Methods
The age-, and sex-specific effects were estimated using an instrumental variable approach with genetic variants as instruments (i.e., Mendelian randomisation) in an effort to deal with reverse causality and omitted variables that may bias the relationship between BMI and income. We also reduced measurement error by using registry-based income and clinically measured height and weight.
Findings
Elevated BMI led to a reduced likelihood of working, and lower income. For females, increased BMI led to lower income throughout, and particularly at the end of, work life. For males, increased BMI led to lower income from age 49 onwards.
Bioaccumulation of chemical elements in the largemouth bass (Fish): Insight from three Missouri reservoirs
Authors: Onema pauline , Ikem Abua , Knot Kattrina , Adojoh Onema 
Published: November 2022

Abstract
Due to the bioaccumulation and biomagnification effects of Methyl Mercury (MeHg), elevated Hg concentration in fish has been found in some lakes and new impoundment reservoirs. Thus, this study analyzes the presence of Mercury (Hg), arsenic (As), cadmium (Cd), selenium (Se), lead (Pb), nickel (Ni), and zinc (Zn) to determine the composite of whole-body largemouth bass (LMB; Micropterus salmoides) samples across three Missouri Lakes. The three lakes (Port Hudson, Buffalo Bill, and Ben Branch reservoirs) were compared with US-EPA Standard values to determine the concentration of 26 elements (Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, Se, V, Zn, B, Hg, Pb, P, Tl, Be, Ba, Sb, Ag, Al, and As) in largemouth bass (LMB; skin–off fillet). The two methods were validated from the analyses of certified reference materials (DOLT-5 and DORM-4). In addition, the weekly intakes of metals and metalloids in comparison with regulatory thresholds and the non-carcinogenic and carcinogenic risks via the consumption of muscle are observed. The overall elemental content of LMB from the three reservoirs shows the metal levels in this study were below the maximum limits.
Gut and respiratory tract microbiota in children younger than 12 months hospitalised for bronchiolitis compared with healthy children. Can we predict the severity and medium-term respiratory outcome?
Authors: Cabrera-Rubio Raul , Calvo Cristina , Alcolea Sonia , Bergia María , Atucha Jorge , Pozo Francisco , Casas Inmaculada , Arroyas María , Collado María Carmen , García-García María Luz 
Published: November 2022

Abstract
Background: Growing evidence indicates that infant microbiota has a potential key effect on bronchiolitis. However, little is known about the potential factors, such as the presence of respiratory syncytial virus (RSV) and viral coinfection, in both the gut and respiratory tract microbiota of children younger than 12 months hospitalised for bronchiolitis compared with children with no identified viruses and with healthy children.
Methods: This was a case control, multicentre, prospective study in 2 hospitals (Severo Ochoa University Hospital and La Paz University Hospital) that included 96 infants (57 cases and 39 controls). Gut (faeces) and respiratory (nasopharyngeal aspirate [NPA]) microbial profiles were analysed by 16S rRNA gene sequencing, and respiratory viruses were identified by targeted multiplex reverse transcription-polymerase chain reaction assays. Clinical data of the acute episode, respiratory morbidity and follow-up during the first year after infection were recorded.
Results: Pairwise comparisons showed significant differences in gut (R2=0.0639, P=0.006) and NPA (R2=0.0803, P=0.006) microbiota between the cases and healthy controls. A significantly lower richness in the intestinal microbiota and an increase in the diversity of the respiratory microbiota (but with an increase in bacteria such as Haemophilus, Streptococcus and Neisseria) were observed in the infants with bronchiolitis, in those with the most severe symptoms and in those who subsequently developed recurrent wheezing episodes in the year after discharge. In NPA, the microbial richness differed significantly between the control group and the non-RSV bronchiolitis group (P=0.01) and between the control group and the RSV bronchiolitis group (P=0.001). In the gut, the richness differed significantly between the control group and the non-RSV group (P=0.01) and between the control group and the RSV bronchiolitis group (P=0.001), with higher diversity in the RSV group.
Conclusions: A distinct respiratory and intestinal microbiota pattern was observed in infants with bronchiolitis compared with healthy controls. The presence of RSV was a main factor as a catalyst for dysbiosis. Lower gut microbial richness and increased respiratory microbial diversity were observed in the infants with respiratory morbidity during follow-up.
Prevalence of Toxoplasma gondii in buffaloes (Bubalus bubalis) and cows (Bos taurus) at the Tabriz abattoir, Iran
Authors: Jabbari Javad , Hajipour Nasser , Hassanzadeh Parviz , Ketzisc Jennifer 
Published: November 2022

Abstract
Toxoplasma gondii is a widely prevalent zoonotic protozoan parasite in humans and warm-blooded animals worldwide. Humans usually become infected through consuming water or food contaminated with oocysts or by ingesting tissue cysts in undercooked meat. The aim of this study was to assess the presence of T. gondii in the meat of buffaloes and cows slaughtered in Tabriz slaughterhouse, Iran using PCR. Fifty grams of heart, thigh, diaphragm and tongue of 50 buffalo and 100 cows slaughtered at the Tabriz industrial slaughterhouse were randomly sampled and tested using a previously published PCR method. Of the 150 animal samples, T. gondii was detected in 10 (6.6%) including one buffalo (2%) and nine cows (9%). The rate of infection was the same for buffalo and cattle (P > 0.05). Also, there was no significant relationship between the rate of infection and age, sex or organs assessed (P > 0.05). Although the rate of infection of animals slaughtered in Tabriz slaughterhouse is low, the presence of T. gondii still poses a risk to human health. Therefore, appropriate and effective preventive measures should be taken to limit the transmission of this parasite to humans and the consumption of raw and undercooked meat should be discouraged.
Optical Coherence Tomography Angiography (OCTA) findings in a patient with acute traumatic choriocapillaropathy
Authors: Astaneh Mohamadreza Ansari , Hedayati Maryam , Shariati Mehrdad Motamed 
Published: November 2022

Abstract
Acute traumatic maculopathy included a spectrum of disorders following blunt ocular trauma, such as traumatic pigment epitheliopathy, commotio retina, and choroidal rupture. Our patient was a 47-year-old male who came to the emergency department due to blurred vision in his left eye for the past two weeks following blunt ocular trauma. His best-corrected visual acuity was 10/10 in the unaffected right eye (OD) and 7/10 in the left eye. In fundus examination, we found decreased foveal reflex and gray-white spots in a ring-like pattern at the parafovea and an area of pigmentary change below the superior arcade near the disc. Optical coherence tomography (OCT) demonstrated disruption of the Ellipsoid zone, and Optical coherence tomography angiography (OCTA) showed dark dot signals in choriocapillaris at the same site. As we showed in this article, traumatic choriocapillaropathy, which can be described as spots of flow disruption within choriocapillaris can occur without any injury to the retinal vasculature.
Pterostilbene upregulates MICA/B via the PI3K/AKT signaling pathway to enhance the capability of natural killer cells to kill cervical cancer cells
Authors: Li Zuoping , Zhang Jiaru , You Shiwan , Zhang Jing , Zhang Yuling , Akram Zubair , Sun Shiguo 
Published: November 2022

Abstract
Natural killer (NK) cells are the main effector of the innate immune response of cells undergoing a malignant transformation in cancer microenvironment. NK cells recognize their targets through a complex array of activating and inhibitory receptors, which regulate the intensity of the effector response against individual target cells. However, many studies have shown that the shortage of the major histocompatibility complex class I chain-related proteins A and B(MICA/B) on the surface of cancer cells can evade the recognition of immune cells and produce resistance to NK cell killing. Through consulting the database and molecular docking, it was found that pterostilbene (PTS;3,5-dimethoxy-40-hydroxystilbene) in blueberry extract may inhibit PI3K/AKT signaling pathway and up-regulate the expression of the MICA/B in cervical cancer. MTT assay, flow cytometry, colony formation assay and viability/cytotoxicity assay evaluated the effects of PTS on cervical cancer cell proliferation and apoptosis. The results of western blot and quantitative real-time polymerase chain reaction (qRT-PCR) further confirmed that PTS could regulate the cytolytic activity of NK cells to cancer cells by up-regulating the expression of MICA/B, and modulate the anti-cancer immune response in cervical cancer.
An intelligent detection method for plasmodium based on self-supervised learning and attention mechanism
Authors: Fu Min , Wu Kai , Li Yuxuan , Luo Linkai , Huang Wei , Zhang Qi 
Published: November 2022

Abstract
Background： Malaria is still a serious life-threatening disease caused by plasmodium parasites. Microscopy is a widely used method for malaria diagnosis. However, it is relied heavily on the skills and experience of inspectors. There are many misdiagnoses in the areas with low medical level or few cases due to the lack of skilled inspectors.
Methods： In recent years, CNN models has gained many successful applications in image classification. Unlike the objects in the ImageNet, the image of plasmodium only has a tiny defect area with a large amount of information. In addition, the dataset is extremely unbalanced in which the number of positive samples is much less than the number of negative samples. In this paper, we propose a classification network by combining attention mechanism and ResNeSt for plasmodium detection and use self-supervised learning to pre-train the network. First, the positive samples are used to pre-train the network. Then, attention modules are used to highlight feature area. To support current and future research, we also construct a plasmodium dataset with Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malaria and non-Plasmodium.
Results： The experiments show that our model obtains an excellent performance where the test accuracy, the sensitivity, and the specificity are 97.8%, 96.5%, 98.9%, respectively.
Conclusion： The AI classification method proposed in this paper can effectively assist clinicians in the diagnosis and provide a basis for the automatic detection of malaria parasites in the future.