bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrimination thresholds for glutamic acid and chicken oil in chicken broth assessed by an untrained panel at a research institute
Authors: Watanabe Genya , Ishida Shota , Akada Karin , Komatsu Masaya , Sakurai Hiroki , Shinoda Saki , Motoyama Michiyo , Nakajima Ikuyo , Asano Atsushi , Miyaguchi Yuji , Sasaki Keisuke 
Published: January 2025

AbstractGlutamic acid (Glu) and fat are recognized as primary flavor components in meat. This study aimed to determine the discrimination threshold of an untrained panel for Glu and fat in meat. Thirty‐two untrained panelists were recruited among research institute employees. First, triangle tests were performed using chicken broth supplemented with Glu at concentrations of 10, 50, 110, and 200 μg/ml and broth without Glu supplementation (control). The Glu supplementation test did not distinguish between Glu‐supplemented broth and the control. Thus, the discrimination threshold for Glu in chicken broth was determined to be >200 μg/ml. Second, triangle tests were performed using chicken oil‐emulsified broth at concentrations of 43, 129, 387, and 1160 μg/ml and broth without chicken oil supplementation. The probability of choosing the correct sample in the triangle test for each chicken oil concentration was calculated. The probit regression analysis estimated the discrimination threshold for chicken oil in chicken broth to be 341 μg/ml among untrained panelists. Although the number of untrained panelists recruited in this study was limited, our results provided useful findings for evaluating and improving meat quality utilizing Glu and fat content.
Green Finance and Climate Technology: Evidence From a Quasi‐Natural Experiment
Authors: Yang Xiaotong , Tian Jinfang , Yan Hao , Qin Peng 
Published: January 2025

ABSTRACTAddressing the productivity challenge of climate technology (ClimTECH) firms and avoiding the “green trap” is crucial for decoupling economic growth from carbon emissions and achieving sustainable development. This study uses the establishment of green finance reform and innovation pilot zones as a quasi‐natural experiment and employs a difference‐in‐differences model to explore the impact of green finance policies on the total factor productivity (TFP) of ClimTECH firms and its spillover effects. The results show that (1) Green finance policies significantly increase TFP, especially in state‐owned firms, firms that actively disclose environmental information, firms led by long‐tenure CEOs, and those in regions with strong intellectual property protection. (2) The channel analysis shows that green finance policies enhance firms' TFP by easing financing constraints, encouraging green technology improvements, and improving capital allocation efficiency. (3) The spillover effect analysis shows that the TFP increase driven by green finance policies not only enhances firm value but also stimulates local green innovation and reduces regional carbon emissions. This research offers theoretical insights and policy implications for strengthening green finance frameworks and enhancing the environmental responsibility of ClimTECH firms.
Iberdomide, ixazomib and dexamethasone in elderly patients with multiple myeloma at first relapse
Authors: Touzeau Cyrille , Leleu Xavier , Tiab Mourad , Macro Margaret , Perrot Aurore , Gay Julie , Chateleix Carine , Moreau Stéphane , Karlin Lionel , Jacquet Caroline , Manier Salomon , Hulin Cyrille , Decaux Olivier , Richez Valentine , Chalopin Thomas , Mohty Mohamad , Orsini‐Piocelle Frédérique , Caillot Denis , Sonntag Cécile , Vignon Marguerite , Bobin Arthur , Avet‐Loiseau Hervé , Jobert Alexandra , Planche Lucie , Corre Jill , Moreau Philippe 
Published: January 2025

SummaryMost transplant‐ineligible patients present with multiple myeloma (MM) refractory to lenalidomide and/or anti‐CD38 monoclonal antibody at first relapse and represent a difficult‐to‐treat population. The Intergroupe Francophone du Myélome phase 2 study iberdomide, ixazomib and dexamethasone (I2D) evaluated the oral triplet iberdomide, ixazomib and dexamethasone in MM patients aged ≥70 years at first relapse (NCT04998786). Seventy patients were enrolled to receive iberdomide (1.6 mg on day 1–21), ixazomib (3 mg on day 1, 8, 15) and dexamethasone (20 mg on day 1, 8, 15, 22 on cycle 1–2 and 10 mg on day 1, 8, 15, 22 on cycle 3–6) (28‐day cycle) until disease progression. Median age was 76; 50% patients were frail according to the International Myeloma Working Group frailty score; 74% and 37% were refractory to lenalidomide and daratumumab respectively. With a median follow‐up of 14 months, the overall response rate was 64%, including 36% very good partial response or better. The 12‐month progression‐free survival, duration of response and overall survival were 52%, 76% and 86% respectively. The most common (46%) grade 3–4 toxicity was neutropenia. Non‐haematological adverse events were mostly grade 1 or 2. Overall, I2D demonstrated a favourable risk–benefit profile in elderly MM patients at first relapse, including in patients with lenalidomide and daratumumab refractory disease.
Assessment of fit of item response theory models: A critical review of the status quo and some future directions
Authors: Sinharay Sandip , Monroe Scott 
Published: January 2025

AbstractThis paper provides a literature review of assessment of fit of item response theory models. Various types of fit procedures for item response theory models are reviewed, with a focus on their advantages and disadvantages. Real data examples are used to demonstrate some of the fit procedures. Recommendations are provided for researchers and practitioners who are interested in assessing the fit of item response theory models.
Quantification of Lawsone and p‐Phenylenediamine in Natural Henna Products for Hair Colouring Available in Poland
Authors: Sienkiewicz‐Szłapka Edyta , Janysz Arleta , Wróbel Michał H. 
Published: January 2025

ABSTRACTBackgroundHenna is a powdered plant material traditionally used for medicinal and cosmetic purposes in Asia and the Mediterranean region. In North America and Europe, however, it is only used to colour the hair and decorate the body. This colouring process is due to the action of the secondary metabolite lawsone, which enables henna to produce orange to red shades of colour. The final colour effect of the henna treatment on the hair depends on many factors, including the amount of lawsone in the product used. Unfortunately, there are also henna products on the market that contain the strong allergen para‐phenylenediamine (PPD). Henna products whose manufacturers do not inform consumers about the addition of PPD are a particular problem.ObjectivesThe aim of this study was therefore not only the qualitative and quantitative evaluation of lawsone but also of PPD in selected products offered for sale as henna.MethodsSince HPLC assays are one of the most sensitive, rapid and reliable methods for the quality control of herbal raw materials, we developed and validated two independent HPLC methods with UV detection for both analytes.Results and ConclusionsWe found that only about 60% of the tested cosmetic products were good quality natural products containing not < 0.5% lawsone (the range was between 0.5% and 1.0%). On the other hand, up to 36% of the henna samples contained PPD (the range was between 1% and 9%), and only three out of five of these products were properly labelled. Unfortunately, most of the henna used by Polish consumers comes from online retailers and can be shipped from different regions of the world. It is difficult to adequately control this market. Therefore, proper consumer education and awareness of the risk of PPD exposure when using henna could also be crucial for the prevention and management of PPD allergy.
Impact of Day 11 Methotrexate Dose Adjustments due to Mucositis on the Outcomes Following Allogeneic Stem Cell Transplant in the Setting of Anti Thymocyte Globulin (ATG) Based GVHD Prophylaxis
Authors: Dhir Vinita , Prince Connor , Allan David , Atkins Harold , Bredeson Christopher , Kekre Natasha , Kennah Michael , Masurekar Ashish , Vasudevan Nampoothiri Ram 
Published: January 2025

ABSTRACTBackgroundDose adjustments of Day 11 Methotrexate (MTx) for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation (HCT) are common due to mucositis, renal injury, or other reasons. The impact of omitting or adjusting doses of MTx in the era of ATG‐based GVHD prophylaxis remains unexplored.MethodsWe retrospectively analyzed the outcomes of all adult patients undergoing allogeneic HCT who received ATG‐based GVHD prophylaxis at The Ottawa Hospital from January 2019 to December 2022. We compared outcomes of patients having only Day 11 MTx dose reductions due to mucositis(MTxRD group) with patients receiving full dose MTx on all 4 days (MTxFD group). The impact of Day 11 MTx dose reduction on outcomes were assessed using Kaplan–Meier analyses and log rank test.ResultsThree hundred and four patients (median age 58 [17–74] years; 64% male) underwent allogeneic HCT during the study period. Baseline characteristics were similar between the MTxRD group (n = 69) and MTxFD group (n = 199) except for an increased proportion of MAC regimens in MTxRD group. The incidence of severe aGVHD (7.2% vs. 7.5%; p = 0.96) and chronic GVHD (15.9% vs. 15.6%; p = 0.89) were not different between the two groups. The 2‐year OS (59% vs. 69.8%; p = 0.11), GRFS (42.4% vs. 47.6%; p = 0.32), NRM (17.7% vs. 12.2%; p = 0.45) or relapse/progression (CIR 27.4 vs. 26.6%; p = 0.55) were also similar between the two groups.ConclusionsIn patients receiving ATG‐based GVHD prophylaxis regimens, there were similar GVHD and survival outcomes in patients who received no or reduced D11 MTx when compared to full dose MTx. Dose adjustments of D11 MTx due to mucositis appear to be safe in the era of ATG‐based GVHD prophylaxis regimens.
Myotilin gene duplication causing late‐onset myotilinopathy
Authors: Spinazzi Marco , Savarese Marco , Letournel Franck , Sagath Lydia , Manero Florence , Guichet Agnès , Hoischen Alexander , Metay Corinne , Gouju Julien , Udd Bjarne 
Published: January 2025

AbstractBackgroundmyotilinopathy is a very rare inherited muscle disease that belongs to the group of myofibrillar myopathies. These diseases share a common alteration of the sarcomere organization at the level of the Z disk resulting in pathological protein aggregation, autophagic abnormalities, and ultimately muscle degeneration. Most reported cases are due to dominant missense mutations in the MYOT gene, two of which are largely recurrent.MethodsWe describe the clinical, radiological, pathological, and molecular analysis including long‐read sequencing of a family affected by late‐onset dominant proximodistal myopathy and muscle hypertrophy.ResultsWe identified a duplication of the entire MYOT gene as the molecular cause of late‐onset‐myotilinopapthy with typical clinical and pathological features.ConclusionsThis study expands the molecular spectrum of myotilinopathy and highlights the use of long‐read sequencing in the diagnosis of genetic neurological diseases caused by duplications and genomic structural variants. Myotilinopathy as well as other myofibrillar and distal myopathies should be considered in the differential diagnosis of patients affected by distal muscle weakness, even when presenting at an old age.
Clinical utility of 18F‐fluorodopa positron emission tomography in the movement disorder clinic: an Australian experience
Authors: Yeow Dennis , Fielder Matthew , Hynard Shane , Adam Robert , Katz Matthew , Lehn Alexander , Thomas Paul , O'Sullivan John D. 
Published: January 2025

AbstractBackgroundDifferentiating idiopathic Parkinson disease (iPD) from other causes of tremor and parkinsonism based on clinical grounds can be challenging, particularly early in the course of disease or in the case of atypical clinical presentations. 18F‐fluorodopa (F‐DOPA) is a positron emission tomography (PET) radioligand that can be used to demonstrate the presence and pattern of striatal presynaptic dopaminergic deficit and, thus, assist in the diagnosis of iPD and related disorders.AimsTo determine the clinical utility of F‐DOPA PET in an Australian movement disorder clinic setting.MethodsRetrospective cohort study of movement disorder clinic patients referred for F‐DOPA PET by four movement disorder neurologists over a 10‐year period to a single Australian nuclear medicine centre. Results of F‐DOPA PET scans were correlated with changes in provisional diagnosis and management in the short term following review of F‐DOPA PET results.ResultsA total of 105 F‐DOPA PET scan results and patient records were examined. In this cohort, provisional clinical diagnosis was altered in 37.9% of patients, and changes to clinical management were made in 48.4% of patients in the short term following review of F‐DOPA PET results. Changes in both diagnosis and management were more common following a normal F‐DOPA PET scan result (42.4% and 53.0% respectively) than a scan consistent with iPD (23.5% and 32.4% respectively).ConclusionsThere was significant change in provisional clinical diagnosis and management in the short term following review of F‐DOPA PET results indicating significant clinical utility of F‐DOPA PET in the Australian movement disorder clinic setting.
An optimization model for the energy management of the network of tanks in a drinking water distribution system
Authors: Djeumou Fomeni Franklin , Ali Montaz , Fernández David Abert , Cabrera‐Codony Alba , Monclús Hèctor 
Published: January 2025

Abstract“L'eau c'est la vie” is a well‐known French expression for “water is life,” which reflects the fact that water is undoubtedly the most vital resource in the world. The main mission for water utility companies is to convey and distribute water that is of acceptable quality to satisfy the demand of the population at any time of the day. In the recent years, achieving this mission has become very challenging for these companies. Indeed, on the one hand, the rapid growth of population and the expansion of urbanization have significantly increased the demand for water, while on the other hand, natural phenomenon, such as drought, as well as the impact of climate changes are making it almost impossible for water distribution companies to convey the right amount of water where and when it is needed. The presence of water storage tanks in a water distribution network is aimed at alleviating this pressure by storing water and distributing it later in response of the variability of the demand across the network. The management of the tanks of the network is done based on the assignment of three‐level set points, which allows to meet the outflow demand of water from each tank, while maintaining the adequate flow rate through the network. The set points define the level at which the valves that enable inflow and outflow of water to the tank have to be switched on or off. However, operating the valves during different periods of the day to meet the water demand may yield extremely high operational cost because opening some of the valves will induce the running of pumps to maintain an adequate flow rate of water in the network. We present a network optimization model for managing the network of storage tanks in a drinking water distribution system while minimizing the total cost of electricity involved. Computational experiments have been conducted on up to three sets of distribution networks. The results show that our proposed optimization model can be used to reduce the operational cost of managing the network of storage tanks for a water distribution system by up to 38%, while still being able to maintain the right amount of water in the tanks.
Effects of Shade Stress on the Synthesis of Cellulose and Lignin in Maize Nodal Roots
Authors: Shengqin Liu , Yuze Liu , Shengqun Liu , Yue Ma , Mingmei Dai , Junren Liu , Chang Liu 
Published: January 2025

ABSTRACTLow solar radiation is an important factor affecting maize root growth and development. Roots have an anchoring function, and their important components are cellulose and lignin. Here, shade experiments were conducted using shade nets with 50% light transmittance (L50). The experiment was conducted in 2021 and 2022 using the ‘Xianyu 335’ maize variety under two nitrogen conditions (N1 = 180 kg ha−1 and N2 = 240 kg ha−1) to investigate the effect of shading on the structural carbohydrate content of maize nodal roots. The results showed that light had a highly significant effect on cellulose and lignin contents. Compared with normal light (L100), the cellulose content significantly decreased by 10.36%–13.87% and the lignin content significantly decreased by 12.96%–18.68% under shading (L50). Shading decreased the sucrose and soluble sugar contents and the cellulose and lignin‐related enzyme activities. The cellulose and lignin contents were significantly positively correlated with the sucrose content. The cellulose content at the silking (R1) stage was significantly positively correlated with the soluble sugar content and sucrose synthase (SS) and sucrose phosphate synthase activities at the 15th leaf (V15) stage; the lignin content at R1 was significantly positively correlated with the soluble sugar content and SS, acid invertase, tyrosine ammonia‐lyase, cinnamyl alcohol dehydrogenase, polyphenol oxidase and peroxidase activities at V15. Genes related to cellulose synthesis, including sucrose synthase (SS), cellulose synthase (CESA), cellulose synthase‐interactive protein 1 (CSI1), Chitinase‐Like1 (CTL1) and STELLO2 (STL2), were downregulated under shading, as were the lignin synthesis‐related phenylalanine/tyrosine ammonia‐lyase (PTAL), 4‐coumarate‐CoA ligase (4CL) and peroxidase (POD) genes. Auxin and jasmonic acid were significantly affected by light and decreased under shading, thereby reducing cellulose and lignin synthesis. These findings provide theoretical support for the development of appropriate maize cultivation practices under reduced solar radiation.
The effect of pressure on the aluminoborosilicate glass optical basicity
Authors: Haryouli Gabin , Soudani Sami , Grolleau Stéphane , Paris Michael , Morizet Yann 
Published: January 2025

AbstractThe glass optical basicity (Λ) is an adequate way of representing a glass composition that has been successfully applied for glasses made under ambient pressure conditions. However, we do not know if the proposed calculation based on the glass structure and the proposed measurement involving the determination of glass refractive index can apply to glasses made under high‐pressure conditions. We studied several aluminoborosilicate glass compositions synthesized under high‐pressure conditions up to 3 GPa and 1250°C. Recovered glasses were characterized to determine the refractive index (nD) and the density (ρ). The glass structure was determined using 11B and 27Al nuclear magnetic resonance. Increasing pressure up to 3 GPa increases nD and ρ for the studied glasses. Change in the glass structure is consistent with previous studies showing an increase in Al coordination, especially for Ca‐bearing glass composition; and an increase in the proportion of BO4 species. The glass optical basicity decreases with increasing pressure. From the structural changes, Λ decreases by ∼2% from ambient to 1 GPa in pressure for the investigated glass compositions.
Hybridized microstructures of oxygen‐defective HfO2−x films produced by controlling oxidation of metallic Hf foil
Authors: Matsuda Mitsuhiro , Imamura Kai , Kusuda Kaori , Shozaki Masahiro , Shida Kenji , Matsuda Motohide 
Published: January 2025

AbstractWe successfully produced a dopant‐free oxygen‐defective HfO2−x film that exhibit room‐temperature ferromagnetism via a heat treatment of metallic Hf foil at 1673 K for 10 h under an oxygen partial pressure of 1.0 × 10−4 atm. The sample, which exhibits ∼50% transmission of visible light, demonstrates room‐temperature ferromagnetism, with saturation and residual magnetizations of ∼0.05 emu/g and ∼0.005 emu/g, respectively. The HfO2−x film comprises columnar grains several hundred nanometers wide and several micrometers long. High‐angle annular dark‐field scanning electron microscopy observations indicated that the tetragonal HfO2 structure was distributed in nanodomains within the monoclinic HfO2 grains; that is, the films exhibited a hybridized microstructure. The tetragonal HfO2 structure would be mainly due to the introduction of oxygen deficiencies, which led to the room‐temperature ferromagnetism.
Pairing Residual Contact Insecticide Use With Long‐Lasting Insecticide‐Incorporated Netting to Reduce Dispersal and Damage by Stored Product Insects
Authors: Ranabhat Sabita , Abshire Jennifer , Castaldi Joseph , Scheff Deanna S. , Bingham Georgina V. , McKay Tanja , Zhu Kun Yan , Morrison William R. 
Published: January 2025

ABSTRACTLong‐lasting insecticide‐incorporated netting (LLIN) can intercept insects and has shown promise for pest management before and after harvest in agriculture. Understanding how to incorporate LLIN into existing integrated pest management (IPM) programs, with other commonly used tactics like residual contact insecticides, can significantly enhance IPM programs at food facilities. In this study, we assessed whether LLIN (0.34% alpha‐cypermethrin, BASF) may enhance the effects of residual contact insecticides such as Centanyl EC (Central Life Sciences), active ingredient (a.i.) deltamethrin and Evergreen (McLaughlin Gormley King Co.), a.i. natural pyrethrins against Tribolium castaneum and Rhyzopertha dominica. We recorded their dispersal and progeny production in treatments with LLIN alone, deltamethrin or pyrethrins alone, LLIN + insecticide, or no treatment (positive control). We demonstrated the use of both LLIN and residual insecticide with either deltamethrin or pyrethrins reduced adult insect dispersal to the food sources compared to the control, but only increased control of progeny production marginally by 8%–19%. LLIN alone was highly effective in reducing progeny production of T. castaneum by 40% compared to the positive control. Importantly, pyrethrins did not cause significant direct mortality or prevent progeny production when used alone against T. castaneum. However, the combined use of pyrethrins with LLIN showed an enhanced efficacy against the insect. Together, the combined use of LLIN and the residual contact insecticides evaluated in our study may have some benefits over using residual contact insecticide alone to manage stored product insects.