bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological risk assessment of a pelagic seabird species in artisanal tuna fisheries
Authors: García-Barón Isabel , Granado Igor , Astarloa Amaia , Boyra Guillermo , Rubio Anna , Fernandes-Salvador José A , Zarauz Lucía , Onandia Iñigo , Mugerza Estanis , Louzao Maite 
Published: August 2022

Abstract
Fishery bycatch is a serious threat to several protected, endangered, and threatened species (PETs), requiring urgent action to develop and implement conservation measures. This study performs an Ecological Risk Assessment for the Effects of Fishing (ERAEF) using a spatially and temporally Productivity–Susceptibility Analysis (PSA) to calculate the potential risk to great shearwaters (Ardenna gravis) from direct interaction with the metiers of the artisanal tuna fishing fleet at the Bay of Biscay (baitboats and trollers). The PSA incorporates productivity attributes based on the Fecundity Factor Index; and susceptibility attributes calculated from the species spatio-temporal abundance patterns obtained developing density surface models and distribution and intensity of fishing activity based on pooled Vessel Monitoring System and logbook data. The PSA shows an overall moderate risk to great shearwaters by the artisanal tuna fishery also revealing that baitboats are less risky than trollers (risk score of 3.12 ± 0.09 and 2.70 ± 0.05, respectively). Spatially, the likelihood of presence of high potential risk areas was associated with prey availability for both the PET and the commercial fish species. The systematic, repeatable, and standardized ERAEF followed in this study can be used to advice for ecosystem-based fisheries management to improve management measures for reducing bycatch of PETs around the world.
Intoxications in an Australian Emergency Department Involving ‘Nitazene’ Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene)
Authors: Schumann Jennifer L , Syrjanen Rebekka , Alford Katherine , Mashetty Srujana , Castle Jared W , Rotella Joe , Maplesden Jacqueline , Greene Shaun L 
Published: August 2022

Abstract
Benzimidazole synthetic opioids are highly potent μ-opioid receptor agonists with heroin-like effects, including dose-dependent respiratory depression and a high risk of abuse and toxicity. Benzimidazoles were first detected in 2019 in Europe and Canada, with analytical confirmation of etodesnitazene, protonitazene and butonitazene in 2021. We report the first detections of these compounds in Australia, in two patients presenting with drug toxicity to Emergency Departments (EDs) in the state of Victoria. Case 1 was a female in her 20s who rectally administered etodesnitazene and was found unconscious with respiratory depression and hypotension. Case 2 was a female in her 30s who presented to the ED in a sedated state after taking a formulation of protonitazene that also contained butonitazene, in addition to methylamphetamine. She responded positively to naloxone. Novel synthetic opioids were used with prior experience of the formulations purchased; however, the unpredictability of their effects was demonstrated by the acute toxicity experienced with this occasion of use. Toxicosurveillance of ED presentations with analytical confirmation of drugs is crucial in identifying emerging drugs in the community and informing harm reduction strategies.
Iranian Men’s Sexual Life Issues After Their Wives’ Burn: A Qualitative Content Analysis Study
Authors: Eslamialiabadi Hassan , Nasiri Ahmad , Mahmoudirad Gholamhosein 
Published: August 2022

AbstractPhysical and psychological complications of burn injuries reduce the victims’ sexual quality of life and challenge their partners’ sexual satisfaction. There is no information about men’s sexual issues and behaviors. Previous studies did not address the impact of women’s burns on their husbands’ sexual lives. Therefore, this qualitative study aimed to characterize the sexual experiences of Iranian men after their wives’ burns. The study was performed on 16 men with surviving spouses of major burn using criterion-based purposive sampling. Semistructured interviews were analyzed using a qualitative content analysis approach. The results showed men’s sexual issues with three main themes and eight subthemes: 1) sexual desire restrictors (annoying scars, imposing roles, and wives’ sexual coldness), 2) degradation of marital sex (reduced frequency of sexual intercourses, temptation of extramarital affairs), and 3) effort to maintain sex (sexual self-sacrifice, sexual pretending, sexual precautions). According to men’s experiences, female sexual coldness, temptation for extramarital affairs, and sexual pretense were related to couples’ poor knowledge of sexual discourse. Thus, health professionals can use context-oriented educational program to promote the couples’ sexual knowledge and health after burns.
Dynamics of nitration during dark-induced leaf senescence in Arabidopsis reveals proteins modified by tryptophan nitration
Authors: Arasimowicz-Jelonek Magdalena , Jagodzik Przemysław , Płóciennik Artur , Sobieszczuk-Nowicka Ewa , Mattoo Autar , Polcyn Władysław , Floryszak-Wieczorek Jolanta 
Published: August 2022

Abstract
Nitric oxide (NO) is a critical molecule that links plant development with stress responses. Herein, new insights into the role of NO metabolism during leaf senescence in Arabidopsis are presented. A gradual decrease in NO emission accompanied dark-induced leaf senescence (DILS), and a transient wave of peroxynitrite (ONOO–) formation was detected by day 3 of DILS. The boosted ONOO– did not promote tryptophan (Trp) nitration, while the pool of 6-nitroTrp-containing proteins was depleted as senescence progressed. Immunoprecipitation combined with mass spectrometry was used to identify 63 and 4 characteristic 6-nitroTrp-containing proteins in control and individually darkened leaves, respectively. The potential in vivo targets of Trp nitration were mainly related to protein biosynthesis and carbohydrate metabolism. In contrast, nitration of tyrosine-containing proteins was intensified 2-fold on day 3 of DILS. Also, nitrative modification of RNA and DNA increased significantly on days 3 and 7 of DILS, respectively. Taken together, ONOO– can be considered a novel pro-senescence regulator that fine-tunes the redox environment for selective bio-target nitration. Thus, DILS-triggered nitrative changes at RNA and protein levels promote developmental shifts during the plant’s lifespan and temporal adjustment in plant metabolism under suboptimal environmental conditions.
Galaxy And Mass Assembly (GAMA): bulge-disc decomposition of KiDS data in the nearby Universe
Authors: Casura Sarah , Liske Jochen , Robotham Aaron S G , Brough Sarah , Driver Simon P , Graham Alister W , Häußler Boris , Holwerda Benne W , Hopkins Andrew M , Kelvin Lee S , Moffett Amanda J , Taranu Dan S , Taylor Edward N 
Published: August 2022

ABSTRACTWe derive single Sérsic fits and bulge-disc decompositions for 13 096 galaxies at redshifts z &lt; 0.08 in the GAMA II equatorial survey regions in the Kilo-Degree Survey (KiDS) g, r, and i bands. The surface brightness fitting is performed using the Bayesian two-dimensional profile fitting code ProFit. We fit three models to each galaxy in each band independently with a fully automated Markov chain Monte Carlo analysis: a single Sérsic model, a Sérsic plus exponential and a point source plus exponential. After fitting the galaxies, we perform model selection and flag galaxies for which none of our models are appropriate (mainly mergers/Irregular galaxies). The fit quality is assessed by visual inspections, comparison to previous works, comparison of independent fits of galaxies in the overlap regions between KiDS tiles and bespoke simulations. The latter two are also used for a detailed investigation of systematic error sources. We find that our fit results are robust across various galaxy types and image qualities with minimal biases. Errors given by the MCMC underestimate the true errors typically by factors 2–3. Automated model selection criteria are accurate to $\gt 90{{\ \rm per\ cent}}$ as calibrated by visual inspection of a subsample of galaxies. We also present g−r component colours and the corresponding colour–magnitude diagram, consistent with previous works despite our increased fit flexibility. Such reliable structural parameters for the components of a diverse sample of galaxies across multiple bands will be integral to various studies of galaxy properties and evolution. All results are integrated into the GAMA database.
B-Cell depletion therapy in IgG4-related disease: State of the art and future perspectives
Authors: Lanzillotta Marco , Stone John H , Della-Torre Emanuel 
Published: August 2022

ABSTRACTIgG4-related disease (IgG4-RD) is an increasingly recognized immune-mediated fibroinflammatory disorder that promptly responds to glucocorticoids but commonly relapses during steroid tapering or after discontinuation. In the last few years, B-cell depletion therapy with rituximab (RTX) proved to be effective in the induction of remission and maintenance treatment of IgG4-RD, providing a new powerful tool in the management of this emerging condition. In this review, we outline the pathogenetic rationale for using B-cell depleting agents in IgG4-RD, we summarize available clinical experience with RTX in this disease, and we describe future possible therapies targeting B-lymphocytes that are now in the pipeline.
A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma
Authors: Kumthekar Priya , Grimm Sean Aaron , Aleman Roxanne T , Chamberlain Marc C , Schiff David , Wen Patrick Y , Iwamoto Fabio Massaiti , Gursel Demirkan Besim , Reardon David A , Purow Benjamin , Kocherginski Masha , Helenowski Irene , Raizer Jeffrey J 
Published: August 2022

Abstract

Background
Systemic therapies for refractory meningiomas are limited with no FDA-approved therapeutics. Vascular endothelial growth factor (VEGF) is a signaling protein associated with neovascularization, peritumoral edema, and meningioma tumorigenesis.

Methods
This phase II study investigates the efficacy of bevacizumab (BEV), a VEGF binding monoclonal antibody, in patients with progressive Grade I (G1M), Grade II (G2M), Grade III (G3M) meningioma, and other non-parenchymal tumors including vestibular schwannoma (n = 4) and hemangiopericytoma (n = 4) with the primary endpoint of progression-free survival rate at 6-months (PFS-6). Non-meningiomas were included with the respective meningioma grade in the analysis. Secondary endpoints include median overall survival (mOS) and response rate.

Results
Fifty Patients (26 women; median age 54 years; range 23–81), 42 with progressive meningioma were treated: 10 G1M, 20 G2M, and 12 G3M. Prior treatments include surgical resection (41 patients), radiosurgery (24 patients), external beam radiotherapy (28 patients), and chemotherapy (14 patients). Median infusions administered were 16 (range, 2–68). Response was graded using the Macdonald’s criteria. PFS-6, median PFS, and mOS were 87%, 22 months, 35 months for G1M; 77%, 23 months, 41 months for G2M; and 46%, 8 months, 12 months for G3M. Best radiographic responses include stable disease (G1M: 100%; G2M: 85%; G3M: 82%); partial response (G1M: 0%; G2M: 5%; G3M: 0%) and progressive disease (G1M: 0%; G2M: 10%; G3M:18%). The most common toxicities were hypertension (n = 19, 42.2%), proteinuria (n = 16, 35.6%), and fatigue (n = 14, 31.1%).

Conclusion
This study showed BEV is well tolerated and appears to be a promising systemic treatment option for patients with recurrent and refractory meningiomas.
The abscopal effect: systematic review in patients with brain and spine metastases
Authors: Pangal Dhiraj J , Yarovinsky Benjamin , Cardinal Tyler , Cote David J , Ruzevick Jacob , Attenello Frank J , Chang Eric L , Ye Jason , Neman Josh , Chow Frances , Zada Gabriel 
Published: August 2022

Abstract

Background
The abscopal effect is a rare phenomenon whereby local radiation induces a proposed immune-mediated anti-tumor effect at distant sites. Given the growing use of immunotherapies and systemic immune checkpoint inhibitors in neuro-oncologic practice, we aimed to review prior studies pertaining to this phenomenon in the context of tumor shrinkage both within the central nervous system as well as distant disease sites.

Methods
A systematic review in accordance with the PRISMA guidelines was conducted to identify all studies which assessed the abscopal effect in patients with treated metastatic cancer to the brain and/or spine. Articles were included if they reported the abscopal effect in patients (case studies) or if the abscopal effect was explicitly analyzed in case series with cohorts of patients with metastatic brain or spine tumors. Laboratory investigations and clinical trials investigating new therapies were excluded.

Results
Twenty reports met inclusion criteria [16 case reports, 4 case series (n = 160), total n = 174]. Case reports of the abscopal effect were in relation to the following cancers: melanoma (6 patients), breast cancer (3), lung adenocarcinoma (2), non-small-cell lung cancer (2), hepatocellular carcinoma (1), and renal cell carcinoma (1). Eleven patients had irradiation to the brain and 2 to the spine. Patients undergoing whole brain radiotherapy (6) had an average dose of 33.6 Gy over 8–15 fractions, and those undergoing stereotactic radiosurgery (5) had an average dose of 21.5 Gy over 1–5 fractions. One patient had radiation to the body and an intracranial abscopal effect was observed. Most common sites of extracranial tumor reduction were lung and lymph nodes. Ten case studies (57%) showed complete resolution of extra-CNS tumor burden. Median progression-free survival was 13 months following radiation. Four papers investigated incidence of abscopal effects in patients with metastatic melanoma to the brain who received immune checkpoint inhibitor therapy (n = 160); two papers found an abscopal effect in 35% and 52% of patients (n = 16, 21 respectively), and two papers found no evidence of abscopal effects (n = 61, 62).

Conclusions
Abscopal effects can occur following radiotherapy in patients with brain or spine metastases and is thought to be a result of increased anti-tumor immunity. The potential for immune checkpoint inhibitor therapy to be used in combination with radiotherapy to induce an abscopal effect is an area of active investigation.
An investigation of the conformity, feasibility, and expected clinical benefits of multiparametric MRI-guided dose painting radiotherapy in glioblastoma
Authors: Brighi Caterina , Keall Paul J , Holloway Lois C , Walker Amy , Whelan Brendan , de Witt Hamer Philip C , Verburg Niels , Aly Farhannah , Chen Cathy , Koh Eng-Siew , Waddington David E J 
Published: August 2022

Abstract

Background
New technologies developed to improve survival outcomes for glioblastoma (GBM) continue to have limited success. Recently, image-guided dose painting (DP) radiotherapy has emerged as a promising strategy to increase local control rates. In this study, we evaluate the practical application of a multiparametric MRI model of glioma infiltration for DP radiotherapy in GBM by measuring its conformity, feasibility, and expected clinical benefits against standard of care treatment.

Methods
Maps of tumor probability were generated from perfusion/diffusion MRI data from 17 GBM patients via a previously developed model of GBM infiltration. Prescriptions for DP were linearly derived from tumor probability maps and used to develop dose optimized treatment plans. Conformity of DP plans to dose prescriptions was measured via a quality factor. Feasibility of DP plans was evaluated by dose metrics to target volumes and critical brain structures. Expected clinical benefit of DP plans was assessed by tumor control probability. The DP plans were compared to standard radiotherapy plans.

Results
The conformity of the DP plans was &gt;90%. Compared to the standard plans, DP (1) did not affect dose delivered to organs at risk; (2) increased mean and maximum dose and improved minimum dose coverage for the target volumes; (3) reduced minimum dose within the radiotherapy treatment margins; (4) improved local tumor control probability within the target volumes for all patients.

Conclusions
A multiparametric MRI model of GBM infiltration can enable conformal, feasible, and potentially beneficial dose painting radiotherapy plans.
Restraining the escape of lattice oxygen enables superior cyclic performance towards high-voltage Ni-rich cathodes
Authors: Yu Haifeng , Zhu Huawei , Jiang Hongliang , Su Xiaozhi , Hu Yanjie , Jiang Hao , Li Chunzhong 
Published: August 2022

ABSTRACT
Layered Ni-rich cathodes, operating at high voltage with superior cyclic performance, are required to develop future high-energy Li-ion batteries. However, the worst lattice oxygen escape at the high-voltage region easily causes structural instability, rapid capacity fading and safety issues upon cycling. Here, we report a dual-track strategy to fully restrain the escape of lattice oxygen from Ni-rich cathodes within 2.7–4.5 V by one-step Ta doping and CeO2 coating according to their different diffusion energy barriers. The doped Ta can alleviate the charge compensation of oxygen anions as a positive charge centre to reduce the lattice oxygen escape and induce the formation of elongated primary particles, significantly inhibiting microcrack generation and propagation. Additionally, the layer of CeO2 coating effectively captures the remaining escaped oxygen and then the captured oxygen feeds back into the lattice during subsequent discharge. The resultant Ni-rich cathode enables a capacity of 231.3 mAh g−1 with a high initial coulombic efficiency of 93.5%. A pouch-type full cell comprising this cathode and a graphite anode exhibits &gt;1000 times life cycles at 1C in the 2.7–4.5 V range, with 90.9% capacity retention.
Anomalous displacement reaction for synthesizing above-room-temperature and air-stable vdW ferromagnet PtTe2Ge1/3
Authors: Zhu Wenxuan , Song Cheng , Wang Qian , Bai Hua , Yin Siqi , Pan Feng 
Published: August 2022

ABSTRACT
Emerging van der Waals (vdW) magnets provide a paradise for the exploration of magnetism in the ultimate two-dimensional (2D) limit, and the construction of integrated spintronic devices, and have become a research frontier in the field of low-dimensional materials. To date, prototypical vdW magnets based on metals of the first transition series (e.g. V, Cr, Mn and Fe) and chalcogen elements suffer from rapid oxidation restricted by the Hard-Soft-Acid-Base principle, as well as low Curie temperatures (TC), which has become a generally admitted challenge in 2D spintronics. Here, starting from air-unstable Cr2Ge2Te6 vdW thin flakes, we synthesize Ge-embedded PtTe2 (namely PtTe2Ge1/3) with superior air stability, through the displacement reaction in the Cr2Ge2Te6/Pt bilayer. In this process, the anomalous substitution of Cr with Pt in the thermal diffusion is inverse to the metal activity order, which can be attributed to the compatibility between soft-acid (Pt) and soft-base (Te) elements. Meanwhile, the layered uniform insertion of Ge unbalances Pt–Te bonds and introduces long-range ordered ferromagnetism with perpendicular magnetic anisotropy and a Curie temperature above room temperature. Our work demonstrates the anti-metal-activity-order reaction tendency unique in 2D transition-metal magnets and boosts progress towards practical 2D spintronics.
Flavored Tobacco Sales Restrictions and Teen E-cigarette Use: Quasi-experimental Evidence From California
Authors: Dove Melanie S , Gee Kevin , Tong Elisa K 
Published: August 2022

AbstractIntroductionFlavored tobacco sales restrictions (FTSRs) are implemented to reduce access to flavored tobacco products. We examined the association between seven cities with local FTSRs implemented in 2018/2019 and e-cigarette use among high school students in the California Bay Area.Aims and MethodsWe analyzed data from the California Healthy Kids Survey using a difference-in-differences (D-I-D) strategy. We compared pre- and post-policy changes one year after implementation in current and ever e-cigarette use among students attending school in a city with a FTSR (exposed) (n = 20 832) versus without (unexposed) (n = 66 126). Other outcomes included ever marijuana use in an e-cigarette and ease of access to e-cigarettes.ResultsPre- to post-policy, the adjusted odds of current and ever e-cigarette use did not significantly change among students exposed and unexposed to a FTSR. In the adjusted D-I-D analysis, the odds of current (aOR: 1.25, 95% CI: 0.95, 1.65) and ever e-cigarette use (aOR: 1.06, 95% CI: 0.89, 1.26) did not significantly change by exposure group. However, one year post-implementation, the odds of ease of access to e-cigarettes significantly increased among exposed (aOR: 1.57, 95% CI: 1.27, 1.95) and unexposed students (aOR: 1.54, 95% CI: 1.39, 1.70). Similarly, the odds of ever using marijuana in an e-cigarette significantly increased among exposed (aOR: 1.35, 95% CI: 1.19, 1.53) and unexposed students (aOR: 1.29, 95% CI: 1.20, 1.39).ConclusionsLocal FTSRs in the California Bay Area were not associated with a change in e-cigarette use one year post-implementation. Increased ease of access and marijuana use may be explanatory factors.ImplicationsFTSRs were not associated with a decrease in current or ever e-cigarette use among high school students in the California Bay Area one-year post-implementation. Potential explanatory factors are that ease of access to e-cigarettes and using marijuana in an e-cigarette increased. More research is needed to understand the influence of these factors on youth access and behaviors. To address the youth e-cigarette epidemic, a comprehensive approach is needed, including policies, media campaigns, education programs, and cessation tools targeted to youth.
The START domain mediates Arabidopsis GLABRA2 dimerization and turnover independently of homeodomain DNA binding
Authors: Mukherjee Thiya , Subedi Bibek , Khosla Aashima , Begler Erika M , Stephens Preston M , Warner Adara L , Lerma-Reyes Ruben , Thompson Kyle A , Gunewardena Sumedha , Schrick Kathrin 
Published: August 2022

AbstractClass IV homeodomain leucine-zipper transcription factors (HD-Zip IV TFs) are key regulators of epidermal differentiation that are characterized by a DNA-binding HD in conjunction with a lipid-binding domain termed steroidogenic acute regulatory-related lipid transfer (START). Previous work established that the START domain of GLABRA2 (GL2), a HD-Zip IV member from Arabidopsis (Arabidopsis thaliana), is required for TF activity. Here, we addressed the functions and possible interactions of START and the HD in DNA binding, dimerization, and protein turnover. Deletion analysis of the HD and missense mutations of a conserved lysine (K146) resulted in phenotypic defects in leaf trichomes, root hairs, and seed mucilage, similar to those observed for START domain mutants, despite nuclear localization of the respective proteins. In vitro and in vivo experiments demonstrated that while HD mutations impair binding to target DNA, the START domain is dispensable for DNA binding. Vice versa, protein interaction assays revealed impaired GL2 dimerization for multiple alleles of START mutants, but not HD mutants. Using in vivo cycloheximide chase experiments, we provided evidence for the role of START, but not HD, in maintaining protein stability. This work advances our mechanistic understanding of HD-Zip TFs as multidomain regulators of epidermal development in plants.