bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actions artistiques à l’épreuve du confinement : étude du récit biographique d’un Street artiste algérien
Authors: Khelfallah Sheherazad 
Published: February 2025

Cet article se propose de présenter et d’analyser le témoignage biographique d’un « artiste de la rue », algérien subissant les restrictions pandémiques. Notre étude est élaborée à partir d’une enquête par entretien de type récit de vie réaliste et expressif, combinée avec une enquête documentaire de type exploration des documents numériques (confinement Covid 2020-2022).Cet acteur, au parcours atypique, nous livre ses récits et relate ses expériences. L’objectif étant de comprendre les « fragments de la réalité vécue » de ce Street artiste, de saisir ses logiques d’action, de situer ses narrations et de présenter ses reconversions au-delà des représentations communes.Au final, ce récit nous livre une tranche de vie inédite, défiant les chaînes du confinement et capitalisant les contraintes de l’enchaînement. Cet artiste, aux palettes amputées, va réinventer l’art de la rue, l’inscrivant dans la contemporanéité et lui offrant de nouveaux plateaux aux publics numériques, médiatiques et iconiques.
Organisational justice: Moderating turnover intention and citizenship behaviour in Eastern Cape nurses
Authors: Majali Thobela G. , Gcaza Nosiphiwo I. , Gcaza Xolile 
Published: February 2025

Orientation: The business sector is engulfed with severe challenges of globalisation in this decade. Hence, companies fight for survival in order to be on the map again. Organisational justice is believed to be key to sustaining various businesses.Research purpose: The study employed organisational justice as a moderating variable to delve into the relationship between organisational citizenship behaviour and turnover intention.Motivation for the study: It has been argued that it is a challenge to keep employees devoted and still make a landmark in the business. Of course, with a lack of motivation in their careers, and not requiring more resources, workers are obliged to quit the health sector.Research approach/design and method: A sample of 298 nurses in various hospitals, utilising quantitative cross-sectional research.Main findings: The findings indicate that when both organisational justice and organisational citizenship behaviour increase, then the turnover intention decreases.Practical/managerial implications: Justifications to enhance organisational citizenship behaviour is imperative. Hence, discouragement of turnover intentions and increase in production are much to be desired.Contribution/value-add: The contribution of this project gives emphasis to the expanding body of knowledge in South Africa as well as globally.
Uncommon Etiology in the Onset of Trigger Finger: A Case Report
Authors: Nanda Subhamay , Das Gautam , Mahapatra Sunaina , Nepal Niru 
Published: February 2025

Abstract
Trigger finger is a common disorder characterized by the locking or snapping of a digit, that occurs due to blocking of tendon gliding at the pulley and is usually seen due to stenosing tenosynovitis and thickening of the pulleys. Ganglion cysts are typically found in the wrist and hand, with the most common sites being the dorsum of the wrist and the volar side in the distal forearm at the wrist crease. While these locations are frequently observed, ganglion cysts originating from the flexor tendon sheath and presenting as a cause of trigger finger are uncommon, with only a limited number of cases documented in the medical literature. This case report is submitted to report the uncommon cause of the trigger finger, such as a ganglion cyst of the flexor tendon sheath, whose prompt diagnosis and treatment will yield good results.
Thymoquinone mitigates diclofenac-induced hepatorenal toxicity in male Wistar rats by balancing the redox state and modulating Bax/Bcl-2/caspase-3 apoptotic pathways and NF-κB signaling
Authors: Safi Amir , Mohammadi Shakila , Emami Mina , Radaei Alireza , Kalantari-Hesari Ali , Nouri Ali , Rahimi-Madiseh Mohammad , Ahmadi Reza 
Published: February 2025

Background and purpose:
Diclofenac (DF), a widely used non-steroidal anti-inflammatory drug, can induce hepatotoxicity and nephrotoxicity. This study investigated the protective effects of thymoquinone (TQ), a bioactive compound from Nigella sativa, against DF-induced organ damage in rats.

Experimental approach:
Forty-eight male rats were divided into six groups (8 each) and treated orally for seven days as follows: group 1 (control): normal saline; group 2: DF (50 mg/kg); group 3: DF (50 mg/kg) + silymarin (50 mg/kg); groups 4-6: DF (50 mg/kg) + TQ at 10, 20, or 40 mg/kg, respectively. Serum biochemical parameters, hepatorenal oxidative stress markers, pro-inflammatory cytokines, and apoptosis-related genes were assessed. Histopathological examinations of liver and kidney tissues were also performed.

Findings/Results:
DF administration induced significant liver and kidney damage, evidenced by elevated serum biochemical markers, increased oxidative stress, inflammation, apoptosis-related gene expression, and histopathological alterations. TQ treatment, particularly at the highest dose (40 mg/kg) effectively attenuated these changes. TQ improved liver and kidney function, reduced oxidative stress markers, suppressed inflammation, modulated apoptosis-related gene expression, and ameliorated histopathological damage.

Conclusion and implication:
TQ exerted significant protective effects against DF-induced hepatorenal toxicity in rats, potentially through its antioxidant, anti-inflammatory, and anti-apoptotic properties. These findings suggest that TQ may be a promising therapeutic agent for mitigating DF-induced organ damage. However, further research, including clinical trials, is needed to confirm its efficacy and safety in humans.
Dietary silymarin supplementation enhances chemotherapy efficacy of capecitabine and irinotecan and mitigates hepatotoxicity in a mouse model of colon cancer
Authors: Hassani Sepideh , Malekinejad Hassan , Khadem-Ansari Mohammad Hassan , Abbasi Ata , Kheradmand Fatemeh 
Published: February 2025

Background and purpose:
The flavonoid silymarin (SMN) has shown promise due to its antioxidant, anti-inflammatory, and anticancer properties. SMN has been widely used in preclinical and clinical studies to treat various types of cancer, alone and with chemotherapy agents. Recent research suggests that SMN may increase conventional chemotherapy efficacy and reduce adverse effects. Herein, we investigated the therapeutic efficacy of SMN and its combination with capecitabine (CAP) and irinotecan (IRI) in a mouse model of colon cancer.

Experimental approach:
Following 1,2 dimethylhydrazine-induced colon cancer, a modified diet supplemented with SMN (2500 ppm) and mono- and combined therapy of CAP and IRI was used. Serum samples were analyzed for lipid profile, liver function, and inflammatory cytokines. Oxidative stress and inflammation markers, including malondialdehyde (MDA), nitric oxide (NO), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured in colonic, hepatic, and circulatory samples. Colonic BAX and Bcl-2 levels were examined via western blotting and histopathological analysis of colon sections was conducted.

Findings/Results:
SMN alone and combined with chemotherapeutic agents significantly mitigated the elevated inflammatory cytokines liver function enzyme levels, and hyperlipidemia. Furthermore, SMN supplementation with chemotherapy agents enhanced antioxidant activity and reduced lipid peroxidation and inflammatory markers. Significant upregulation of BAX and downregulation of Bcl-2 were observed. In addition, treatment regimens ameliorated carcinogen-induced polyp multiplicity, adenoma formation, dysplastic changes, and lymphocytic aggregation.

Conclusion and implications:
Our results demonstrated that the potential anticancer properties of SMN could enhance chemotherapy efficacy and reduce carcinogen- and chemotherapy-induced hepatotoxicity.
Development and evaluation of Sahasthara Thai medicine remedy in a film-forming spray for topical anti-inflammatory therapy
Authors: Intharit Ninnart , Itharat Arunporn , Choockong Chadchom , Pipatrattanaseree Weerachai , Ketjinda Wichan , Davies Neal M. , Löbenberg Raimar 
Published: February 2025

Background and purpose:
The study aimed to develop a localized topical anti-inflammatory treatment using a Thai medicinal herbal remedy called "Sahasthara," known for its anti-inflammatory properties, to create a film-forming spray (FFS).

Experimental approach:
This research evaluated and developed an FFS formulated with Sahasthara ethanolic extract (SHTe). Subsequently, the optimized formulation was investigated for in vitro anti-inflammatory activity, cell culture toxicity assessment, pharmacological effects, and stability studies.

Findings/Results:
An optimized formulation (F12) was identified, consisting of 1% w/w SHTe and PVP K90, glycerol, PEG 400, sesame oil, a eutectic blend, and ethanol. This clear, smooth surface, yellowish film releases 42.37%, 38.67%, and 68.93% at 8 h, corresponding to a flux of 20.94, 1.92, and 26.32 µg/cm2/h of piperine, plumbagin, and β-asarone, respectively. F12 was determined to have a viscosity, drying time, and spray angle of 20 cps, 4.57 min, and 66.0 degrees. In-vitro anti-inflammatory activity demonstrated nitric oxide (NO) inhibition with an IC50 of 9.18 µg/mL. No apparent toxicity was observed in a skin cell line. This formulation was developed to be physically stable after undergoing freeze-thaw cycles. Although thermodynamic stability studies under accelerated conditions revealed a minor decrease in piperine and β-asarone within the film, the results indicate no statistically significant changes in its anti-inflammatory activity.

Conclusion and implications:
SHTe FFS offers optimal spray ability, a high in-vitro drug release profile, potent inhibition of anti-inflammatory markers, and stability under accelerated conditions. These findings suggest that SHTe FFS can serve as an innovative topical anti-inflammatory treatment.
Modern ultrasound techniques for diagnosing liver steatosis and fibrosis: A systematic review with a focus on biopsy comparison
Authors: Pozowski Patryk , Bilski Mateusz , Bedrylo Maciej , Sitny Paweł , Zaleska-Dorobisz Urszula 
Published: February 2025

BACKGROUND
This review evaluated the diagnostic effectiveness of various ultrasound (US) methods compared to liver biopsy.
AIM
To determine the diagnostic accuracy of US techniques in assessing liver fibrosis and steatosis in adults, using the area under the receiver operating characteristic curve (AUROC) as the standard measure.
METHODS
The review included original retrospective or prospective studies published in the last three years in peer-reviewed medical journals, that reported AUROC values. Studies were identified through PubMed searches on January 3 and April 30, 2024. Quality was assessed using the QUADAS-2 tool. Results were tabulated according to the diagnostic method and the type of liver pathology.
RESULTS
The review included 52 studies. For liver fibrosis detection, 2D-shear wave elastography (SWE) AUROCs ranged from 0.54 to 0.994, showing better accuracy for advanced stages. Modifications, including 2D-SWE with propagation map guidance and supersonic imagine achieved AUROCs of 0.84 to nearly 1.0. point SWE and classical SWE had AUROCs of 0.741-0.99, and 0.507-0.995, respectively. Transient elastography (TE), visual TE, vibration-controlled TE (VCTE), and FibroTouch reported AUROCs close to 1.0. For steatosis, VCTE with controlled attenuation parameter showed AUROCs up to 0.89 (for ≥ S1), acoustic radiation force impulse ranged from 0.762 to 0.784, US attenuation parameter from 0.88 to 0.93, and normalized local variance measurement from 0.583 to 0.875. Most studies had a low risk of bias across all or most domains, but evidence was limited by variability in study quality and small sample sizes. Innovative SWE variants were evaluated in a single study.
CONCLUSION
Modern US techniques can serve as effective noninvasive diagnostic tools for liver fibrosis and steatosis, with the potential to reduce the reliance on biopsies.
Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver
Authors: Zhao Ying , Li Jian-Zhou , Liu Yong-Gang , Zhu Yu-Jin , Zhang Yan , Zheng Wen-Wen , Ma Lin , Li Jia , Wang Chun-Yan 
Published: February 2025

BACKGROUND
Acute drug-induced liver injury (DILI) events caused by chronic liver disease are relatively common. Some researchers believe that nonalcoholic fatty liver (NAFL) increases the overall risk of DILI. The clinical characteristics and prognosis of DILI in the context of NAFL disease (NAFLD) are still unclear. Therefore, hospitalized patients with NAFLD combined with DILI at the Tianjin Second People's Hospital were included in this study. The clinical manifestations, classifications, severities, laboratory indicators, and clinical outcomes of the enrolled patients were analyzed, and the clinical characteristics and prognoses of the NAFL + DILI patients were evaluated.
AIM
To investigate the clinical characteristics and prognosis of DILI in the context of NAFL.
METHODS
Eighty-nine patients diagnosed with DILI and 110 patients diagnosed with both DILI and NAFL at the Tianjin Second People's Hospital were enrolled. Clinical data, including demographic characteristics, clinical features, laboratory test results, pathology findings, autoantibody titers, suspected drugs, and outcomes, were collected from the two groups of patients. All enrolled patients were followed up to determine the liver function recovery time.
RESULTS
Compared with the patients in the DILI group, those in the NAFL + DILI group had higher body mass indices; Controlled Attenuation Parameter scores; and triglyceride, total cholesterol, low-density lipoprotein, and insulin levels. The levels of the cytokines interleukin-4 and complement complement c3 (C3) were also greater in the NAFL + DILI group than in the DILI group. The proportions of patients with cholestatic-type DILI (16.4% vs 4.5%), cholestasis seen on pathoscopy (40.9% vs 25.8%), grade 2 or above DILI (48.18% vs 40.45%), and a recovery time for liver function ranging from 90 to 180 days (30.6% vs 15.5%) were greater in the NAFL + DILI group than in the DILI group. All of the abovementioned differences between the groups were statistically significant (P < 0.05). The autoantibody positivity rates did not significantly differ between the two groups (P > 0.05), and the proportions of patients who progressed to chronic drug hepatitis or autoimmune hepatitis were not significantly different between the two groups (both P > 0.05).
CONCLUSION
In the context of NAFL, DILI is more likely to be cholestatic, with a greater degree of liver injury, a longer recovery time, and more pronounced expression of immune factors.
Association of non-alcoholic fatty liver disease with glycemic control among patients with type 2 diabetes mellitus at Limbe Regional Hospital, Southwest, Cameroon
Authors: Ojong Ebot Walter , Ngemenya Moses Njutain , Tafili Melvis Mwantem , Tanue Elvis Asangbeng , Achidi Eric Akum 
Published: February 2025

BACKGROUND
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency. Non-alcoholic fatty liver disease (NAFLD) is emerging as a public health problem worldwide and affects up to 70% of patients with T2DM. Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals, varying prevalence rates of NAFLD among patients with T2DM, ranging from 34% to 94%, have been reported.
AIM
To determine prevalence and identify associated factors of NAFLD among Limbe patients with T2DM and evaluate correlation with glycemic control.
METHODS
A cross-sectional study was carried out from February to June 2024 among patients with T2DM. Gamma-glutamyl transferase (GGT) activity and serum triglycerides (TGs) were measured by spectrophotometry. NAFLD was diagnosed using the fatty liver index score. Data were analyzed using SPSS version 26.0 for Windows. Student’s t -test was used to compare the means of two groups. The χ 2 test was applied to determine the association of NAFLD and T2DM. Logistic regression analysis was performed to identify predictors of NAFLD. P < 0.05 was considered statistically significant.
RESULTS
Of the 150 patients with T2DM recruited for this study, 63 (58%) were females and the majority (84.7%) had good glycemic control (glycated hemoglobin < 7%). Prevalence of NAFLD among patients with T2DM was 19%. Patients with NAFLD had significantly elevated levels of TGs, GGT, and increased body mass index and waist circumference compared to those without NAFLD. There was a significant association between NAFLD and glycemic control. Predictive factors of NAFLD among patients with T2DM were vegetable intake of less than three times per week [adjusted odds ratio (aOR): 0.131, 95%CI: 0.020-0.839; P = 0.032], central obesity (aOR: 0.167, 95%CI: 0.037-0.748; P = 0.019), and metformin treatment for T2DM (aOR: 0.167, 95%CI: 0.037-0.718; P < 0.001).
CONCLUSION
The prevalence of NAFLD in patients with T2DM in Limbe Regional Hospital was 19%. Age, central obesity, metformin use, and infrequent consumption of vegetables were important predictors of NAFLD.
Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report
Authors: Miyamoto Kiwako , Kondo Sonoko , Kondo Takeo , Ishikawa Ryou , Tani Ryosuke , Inoue Tomoko , Matsunaga Keiji , Minamino Tetsuo , Kusaka Takashi 
Published: February 2025

BACKGROUND
Heterozygous familial hypobetalipoproteinemia (FHBL) is a semi-autosomal disorder that is caused mainly by an APOB variant. It is usually asymptomatic and rarely leads to non-alcoholic steatohepatitis (NASH).
CASE SUMMARY
A 12-year-old boy was referred to our hospital after prolonged elevation of liver enzymes was observed during health checkups in Kagawa Prefecture. Abdominal ultrasound showed a bright liver, and laboratory investigations revealed low low-density lipoprotein cholesterol and apolipoprotein B protein levels. His family history included fatty liver and hypolipidemia in his father, which led to a clinical diagnosis of FHBL. A liver biopsy was performed on suspicion of liver fibrosis based on biomarkers. The liver tissue showed fatty steatosis, inflammation, hepatocyte ballooning, and fibrosis, indicating NASH. Genetic testing detected the APOB variant, and the patient was treated successfully with vitamin E.
CONCLUSION
It is important to assess family history and liver dysfunction severity in non-obese patients with hypolipidemia and fatty liver.
Global landscape of hepatic organoid research: A bibliometric and visual study
Authors: Li Tao , Bo Rong-Qiang , Yan Jun , Johnson Nadia L , Liao Meng-Ting , Li Yuan , Chen Yan , Lin Jie , Li Jian , Chu Fu-Hao , Ding Xia 
Published: February 2025

BACKGROUND
Hepatic organoid-based modelling, through the elucidation of a range of in vivo biological processes and the recreation of the intricate liver microenvironment, is yielding groundbreaking insights into the pathophysiology and personalized medicine approaches for liver diseases.
AIM
This study was designed to analyse the global scientific output of hepatic organoid research and assess current achievements and future trends through bibliometric analysis.
METHODS
Articles were retrieved from the Web of Science Core Collection, and CiteSpace 6.3.R1 was employed to analyse the literature, including outputs, journals, and countries, among others.
RESULTS
Between 2010 and 2024, a total of 991 articles pertaining to hepatic organoid research were published. The journal Hepatology published the greatest number of papers, and journals with an impact factor greater than 10 constituted 60% of the top 10 journals. The United States and Utrecht University were identified as the most prolific country and institution, respectively. Clevers H emerged as the most prolific author, whereas Huch M had the highest number of cocitations, suggesting that both are ideal candidates for academic collaboration. Research on hepatic organoids has exhibited a progressive shift in focus, evolving from initial investigations into model building, differentiation research in stem cells, bile ducts, and progenitor cells, to a broader spectrum encompassing lipid metabolism, single-cell RNA sequencing, and therapeutic applications. The phrases exhibiting citation bursts from 2022 to 2024 include “drug resistance”, “disease model”, and “patient-derived tumor organoids”.
CONCLUSION
Research on hepatic organoids has increased over the past decade and is expected to continue to grow. Key research areas include applications for liver diseases and drug development. Future trends likely to gain focus include patient-derived tumour organoids, disease modelling, and personalized medicine.
Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model
Authors: Huang Yu-Shuang , Gao Wei , Sun Ai-Jun , Pu Chun-Wen , Xu Shuang-Shuang 
Published: February 2025

BACKGROUND
Hepatitis B-associated cirrhosis is an important disease burden in China. However, there is a lack of effective predictors in clinical practice to drive delivery and enable early treatment to delay disease progression.
AIM
To analyzing the clinical characteristics of patients with hepatitis and cirrhosis, the nomogram model was established and validated.
METHODS
The clinical data of 1070 patients with hepatitis B who were treated in our hospital from October 2015 to July 2022 were collected. In a 7:3 ratio, 749 cases were divided into training cohorts and 321 cases were divided into validation cohorts. In addition, the training cohort and validation cohort were further divided into hepatitis group and hepatitis B-related cirrhosis group based on whether the patient progressed to cirrhosis. Binary logistic regression was used to analyze the influencing factors of hepatitis progression to cirrhosis. A roadmap prediction model was established, and the predictive effect of the model was evaluated by patient-subject receiver operating characteristic curve (ROC), and the effectiveness of the model was evaluated by decision curve analysis.
RESULTS
Binary logistic regression analysis was performed using hepatitis B-related cirrhosis = 1 and hepatitis = 0 as dependent variables, and univariate analysis of serological indicators was used as covariates. The results showed that glutamic oxaloacetate aminotransferase/glutamate acetone aminotransferase levels, prothrombin time activity, and hepatitis B e antigen levels were all contributing factors to the progression of hepatitis to cirrhosis. The area under the ROC curve was 0.693 [95% confidence interval (CI): 0.631 to 0.756] for the training cohort and 0.675 (95%CI: 0.561 to 0.790) for the validation cohort. In addition, the decision analysis curves of the prediction models of both the training cohort and the validation cohort confirmed the effectiveness of the nomogram prediction model.
CONCLUSION
Three independent factors influencing the progression to cirrhosis in patients with hepatitis B were identified. The construction of a nomogram prediction model from hepatitis to cirrhosis has high application value as a tool for predicting the occurrence of liver cirrhosis in hepatitis B patients.