bluuebunny/crossref_metadata_2025_split huggingface dataset:
The self‐regulatory consequences of dependence on intelligent machines at work: Evidence from field and experimental studies
Authors: Tang Pok Man , Koopman Joel , Yam Kai Chi , De Cremer David , Zhang Jack H. , Reynders Philipp 
Published: November 2022

AbstractOrganizations are increasingly augmenting employee jobs with intelligent machines. Although this augmentation has a bright side, in terms of its ability to enhance employee performance, we think there is likely a dark side as well. Draw from self‐regulation theory, we theorize that dependence on intelligent machines is discrepancy‐reducing—enhancing work goal progress, which in turn boosts employees’ task performance. On the other hand, such dependence may be discrepancy‐enlarging—threatening employee self‐esteem, which in turn detracts from employees’ task performance. Drawing further from self‐regulation theory, we submit that employees’ core self‐evaluation (CSE) may influence these effects of dependence on intelligent machines. Across an experience‐sampling field study conducted in India (Study 1) and a simulation‐based experiment conducted in the United States (Study 2), our results generally support a “mixed blessing” perspective of intelligent machines at work. We conclude by discussing the theoretical and practical implications of our work.
Hand grip strength‐based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer
Authors: Xie Hailun , Ruan Guotian , Wei Lishuang , Zhang Heyang , Ge Yizhong , Zhang Qi , Lin Shiqi , Song Mengmeng , Zhang Xi , Liu Xiaoyue , Li Xiangrui , Zhang Kangping , Yang Ming , Tang Meng , Song Chun‐Hua , Gan Jialiang , Shi Han‐Ping 
Published: November 2022

AbstractBackgroundThe cachexia index is a useful predictor for cancer cachexia and prognostic assessment. However, its use is limited because of high testing costs and complicated testing procedures. Thus, in this study, we aimed to develop a hand grip strength (HGS)‐based cancer cachexia index (H‐CXI) as a potential predictor of cancer cachexia and prognosis in patients with cancer.MethodsHere, 14 682 patients with cancer were studied, including the discovery (6592), internal validation (2820) and external validation (5270) cohorts. The H‐CXI was calculated as [HGS (kg)/height (m)2 × serum albumin (g/L)]/neutrophil‐to‐lymphocyte ratio. The Kaplan–Meier method was used to create survival curves, and the log‐rank test was used to compare time–event relationships between groups. A Cox proportional hazard regression model was used to determine independent risk factors for overall survival (OS). Logistic regression analysis was used to assess the association of the H‐CXI with short‐term outcomes and cancer cachexia.ResultsThere was a significant non‐linear relationship between the H‐CXI and OS in all cohorts. Patients with a low H‐CXI had significantly lower OS than those with a high H‐CXI in the discovery cohort (6‐year survival percentage: 55.72% vs. 76.70%, log‐rank P < 0.001), internal validation cohort (6‐year survival percentage: 55.81% vs. 76.70%, log‐rank P < 0.001), external validation cohort (6‐year survival percentage: 56.05% vs. 75.48%, log‐rank P < 0.001) and total cohort (6‐year survival percentage: 55.86% vs. 76.27%, log‐rank P < 0.001). Notably, the prognostic stratification effect of the H‐CXI in patients with advanced‐stage disease was more significant than that in patients with early‐stage disease. The multivariate Cox proportional risk regression model confirmed that a low H‐CXI negatively affected the prognosis of patients with cancer in the discovery cohort [hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.71–0.80, P < 0.001], internal validation cohort (HR 0.79, 95 %CI 0.72–0.86, P < 0.001), external validation cohort (HR 0.84, 95% CI 0.79–0.89, P < 0.001) and total cohort (HR 0.80, 95% CI 0.77–0.83, P < 0.001). Multivariate logistic regression models showed that a low H‐CXI was an independent risk factor predicting adverse short‐term outcomes and cancer cachexia in patients with cancer.ConclusionsThe simple and practical H‐CXI is a promising predictor for cancer cachexia and prognosis in patients with cancer.
The role and timing of endoscopic retrograde cholangiopancreatography in acute biliary pancreatitis without cholangitis: A nationwide analysis
Authors: Weissman Simcha , Sharma Sachit , Ehrlich Dean , Aziz Muhammad , Bangolo Ayrton , Gade Amulya , Thompson‐Edwards Ashley , Singla Kushaghar , Venkatesh Harini K. , Hoo Kim Mishka , Muthineni Venkata A. B. , Makrani Moinulhaq , Muthukumar Ananya , Gurumurthy Vaishnavi , Prasad Bodapati A. , Nemalikanti Sanskrita , Thomas Jim , Kasarapu Ritu B. , Chugh Rachita , Narayan Kiran L. , Acharya Ashu , Pandol Stephen J. , Tabibian James H. 
Published: November 2022

AbstractBackground/PurposeThe role and optimal timing of endoscopic retrograde cholangiopancreatography (ERCP) in acute biliary pancreatitis without cholangitis (ABPwoC) remains unclear. Using a large national database, we aimed to examine hospitalization outcomes of patients with ABPwoC as a function of the performance and timing of ERCP.MethodsThis was a retrospective study of adult patients with ABPwoC utilizing the National Inpatient Sample from 2016–2017. Patients who underwent inpatient ERCP were stratified into performance: within 24, 24–48, 48–72, and >72 h of hospital admission. The primary outcome was all‐cause inpatient mortality as a function of the performance and timing of ERCP; secondary outcomes, including healthcare utilization, were assessed. Multivariate modeling was used to adjust for potential confounders. Statistical analyses were conducted using STATA, version 16.0.ResultsOf the 70 030 patients with ABPwoC, 31.37% underwent inpatient ERCP. Performance (aOR: 0.6, p < .05), but not timing (aOR: 0.98, p = .9), of inpatient ERCP was associated with significantly lower all‐cause inpatient mortality. Urgent ERCP (within 24 h) was associated with shorter hospital length of stay, lower charges and cost, and less need for pancreatic drainage procedures, while ERCP within 72 h was associated with less frequent intensive care unit admission (all p < .05).DiscussionBased on this large, nationwide analysis, inpatient ERCP for ABPwoC is associated with lower all‐cause mortality. ERCP within 24 and 72 h, though not associated with lower mortality, are associated with multiple improved clinical outcomes, including lower healthcare charges and costs.
Bile acid profiles in choledocholithiasis and their ability to predict common bile duct stone recurrence after endoscopic retrograde cholangiopancreatography treatment
Authors: Guan Yaping , Zhang Encheng , Zhang Cheng , Ye Zhihan , Zhu Feng 
Published: November 2022

AbstractBackground/PurposeThis study aimed to explore the alteration of bile acid (BA) profiles in patients with choledocholithiasis (CDC) and construct a prediction model for evaluating the risk of common bile duct stone (CBDS) recurrence after endoscopic treatment.MethodsA total of 320 patients (218 with CDC and 102 with nonneoplastic polyps) were enrolled. The serum BA profiles were compared between groups. Both diagnostic score of CDC and prognostic risk score of CBDS recurrence based on BAs were established by least absolute shrinkage and selection operator regression. A nomogram model was developed combining the risk score with clinical factors selected by Cox regression analysis.ResultsThe BA profiles of patients with CDC were different from those of controls, which was mainly exhibited by an increase in conjugated BAs and the ratio of primary to secondary BA and a decrease in the hydrophobic BA ratio. The diagnostic model effectively distinguished patients with CDC from controls with an area under the curve of 0.763. Patients with CDC with a low BA risk score exhibited a high possibility of stone recurrence–free survival. The hazard ratios of history of cholecystectomy, multiple stones (n ≥ 2), bile duct angulation ≥132.7, and low BA risk score were 2.43, 4.18, 0.42, and 0.31, respectively.ConclusionsThe serum BA profiles were altered in patients with CDC and could be used to distinguish patients with CDC from controls. The nomogram model developed for predicting the risk of CBDS recurrence in patients with CDC after endoscopic retrograde cholangiopancreatography treatment had high accuracy and clinical usability.
Cost‐minimization analysis of DTaP‐IPV‐Hib combination vaccine in China: A nationwide cross‐sectional study
Authors: Liu Bei , Cao Bing , Wang Chao , Sun Tao , Miao Yudong , Zhang Sihui , Zhao Tianshuo , Cui Fuqiang 
Published: November 2022

AbstractCombination vaccines can reduce the vaccination visit, simplify the vaccination schedule and efficiently improve management. This study was primarily designed to evaluate the economic impact of integrating the diphtheria‐tetanus‐acellular pertussis inactivated poliomyelitis and Haemophilus influenzae type B (DTaP‐IPV‐Hib) combination vaccine into the China National Immunization Program. A cost‐minimization analysis (CMA) compared the costs associated with direct medical, direct nonmedical, and indirect social costs in four schemes was conducted. A budgetary impact analysis assessed the alternative schemes' financial impact on the healthcare budget. Direct medical costs were extracted using a costing questionnaire and an observational time and motion chart. Direct nonmedical (cost for transportation) and indirect costs (loss of productivity) were derived from parents' questionnaires. Replacement of the current vaccination scheme with DTaP‐IPV‐Hib combination vaccine, resulted in net increases in direct medical costs of 77.64% for alternative scheme 1, 146.54% for alternative scheme 2, and 294.67% for alternative scheme 3, respectively. However, the direct nonmedical and indirect costs and the cost of the alternative schemes were 18.18%, 36.36%, and 63.64% lower than the current scheme for alternative scheme 1, alternative scheme 2, and alternative scheme 3, respectively. From the societal perspective, when compared with the current scheme, the budgetary impact of the three alternative schemes were +66 million Chinese Yuan (CNY) (4.81%), +103 million CNY (7.53%), and +305million CNY (22.35%), respectively. The CMA considered a broader perspective of social costs and indicated that the alternative schemes would result in an overall saving of parents' transportation and work loss costs to bring their children for vaccination, translating into a total cost saving of 18.18%, 36.36%, 63.64%, comparing to the current scheme. Thus, fully or partly using the DTaP‐IPV‐Hib combination vaccine is cost‐saving in the context of China.
Heterogeneity of dynamic shear properties of the meniscus: A comparison between tissue core and surface layers
Authors: Schwartz Gabi , Morejon Andy , Gracia Julissa , Best Thomas M. , Jackson Alicia R. , Travascio Francesco 
Published: November 2022

AbstractDamage to the meniscus has been associated with excessive shear loads. Aimed at elucidating meniscus pathophysiology, previous studies have investigated the shear properties of the meniscus fibrocartilaginous core. However, the meniscus is structurally inhomogeneous, with an external cartilaginous envelope (tibial and femoral surface layers) wrapping the tissue core. To date, little is known about the shear behavior of the surface layers. The objective of this study was to measure the dynamic shear properties of the surface layers and derive empirical relations with their composition. Specimens were harvested from tibial and femoral surface layers and core of porcine menisci (medial and lateral, n = 10 each). Frequency sweep tests yielded complex shear modulus (G*) and phase shifts (δ). Mechanical behavior of regions was described by a generalized Maxwell model. Correlations between shear moduli with water and glycosaminoglycans content of the tissue regions were investigated. The femoral surface had the lowest shear modulus, when compared to core and tibial regions. A 3‐relaxation times Maxwell model satisfactorily interpreted the shear behavior of all tissue regions. Inhomogeneous tissue composition was also observed, with water content in the surface layers being higher when compared with tissue core. Water content negatively correlated with shear properties in all regions. The lower measured shear properties in the femoral layer may explain the higher prevalence of meniscal tears on the superior surface of the tissue. The heterogenous behavior of the tissue in shear provides insight into meniscus pathology and has important implications for efforts to tissue engineer replacement tissues.
Development of an enzymatic cascade to systematically utilize lignocellulosic monosaccharide
Authors: Tang Hengtao , Chen Zhi , Shao Yu , Ju Xin , Li Liangzhi 
Published: November 2022

AbstractBACKGROUNDThe fermentation valorization of two main lignocellulosic monosaccharides, glucose and xylose, is extensively developed; however, it is restricted by limited yield and process complexity. An in vitro enzymatic cascade reaction can be an alternative approach.RESULTSIn this study, a three‐stage, five‐enzyme cascade was developed to convert pretreated biomass to valuable chemicals. First, a ribose‐5‐phosphate isomerase B mutant isomerized xylose to d‐xylulose with high substrate specificity, and a d‐arabinose dehydrogenase continued to reduce d‐xylulose to d‐arabitol. Simultaneously, glucose was utilized for the coenzyme regeneration catalyzed by a glucose dehydrogenase, generating useful gluconic acid and achieving 73% of total conversion rate after 36 h. Then, six kinds of pretreated biomass lignocellulose were hydrolyzed by cellulase and hemicellulase, and corn cob was identified as the initial substrate for providing the highest monosaccharide content. A 65% conversion rate of the lignocellulosic xylose was obtained after 24 h.CONCLUSIONSThis study presents a proof of concept to convert main lignocellulosic monosaccharides systematically by an enzymatic cascade at stoichiometric ratio. © 2022 Society of Chemical Industry.
Exosomal circNFIX promotes angiogenesis in ovarian cancer via miR‐518a‐3p/TRIM44 axis
Authors: Ye Hui , Wang Rui‐Yu , Yu Xiu‐Zhang , Wu Yu‐Ke , Yang Bo‐Wen , Ao Meng‐Yin , Xi Ming‐Rong , Hou Min‐Min 
Published: November 2022

AbstractOvarian cancer (OC) is a gynecological cancer with high mortality. OC‐derived exosomal circRNAs can regulate angiogenesis. This study aims to explore the role and mechanism of exosomal circRNA nuclear factor I X (CircNFIX) derived from OC cells in angiogenesis. Quantitative real‐time polymerase chain reaction was employed to evaluate the levels of circNFIX, miR‐518a‐3p, and tripartite motif protein 44 (TRIM44) in OC and adjacent tissues. Exosomes from the ovarian surface epithelial cell (HOSEpiC) and OC cells (SKOV3 or OVCAR3) were isolated by differential centrifugation. Exosomes were cocultured with the human umbilical vein endothelial cells (HUVECs). The angiogenesis capacity was analyzed by Tube formation assay. 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) and Transwell assays were used to determine the cell viability and migration ability. The dual‐luciferase report, RNA immunoprecipitation (RIP), and RNA pull‐down assays were applied to validate the gene's interaction. CircNFIX and TRIM44 expression were higher and miR‐518a‐3p was lower in OC tissues than in the adjacent tissues. Upregulated circNFIX and TRIM44 were significantly correlated with the tumor size and International Federation of Gynecology and Obstetrics (FIGO) stage of OC patients. HUVECs treated OC‐derived exosomes had higher proliferation, migration, and angiogenesis capacities than the control group. While OC‐derived exosomal circNFIX silencing restrained HUVECs' proliferation, migration, and angiogenesis, compared with the OC‐derived exosomes group. OC‐derived exosomal circNFIX positively regulated TRIM44 expression by targeting miR‐518a‐3p in HUVECs. OC‐derived exosomal circNFIX promoted angiogenesis by regulating the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) pathway via miR‐518a‐3p/TRIM44 axis in HUVECs.
Toward Ultrasensitive, Broadband, Reflection‐Mode In Vivo Photoacoustic Microscopy Using a Bare Glass
Authors: Song Wei , Yang Fan , Min Changjun , Zhu Siwei , Yuan Xiaocong 
Published: November 2022

AbstractAccurate volumetric photoacoustic image reconstruction requires ultrasonic detection with sufficient sensitivity to pressure transients over a broad spectral bandwidth. By using the ultrafast temporal dynamics and high‐sensitivity responses to refractive index changes of optical surface waves, a structureless ultrasonic sensor is proposed for photoacoustic impulse measurement that is manufactured simply by covering a ubiquitous bare glass with several drops of water. Ultrasensitive photoacoustic detection with a broadband frequency response is achieved by converting the photoacoustically modulated phase shift in the optical reflection into a time‐varying polarization. This sensor achieves noise‐equivalent pressure sensitivity at ≈93 Pa while maintaining an acoustic bandwidth of ≈174 MHz. Incorporation of the transparent sensor into an optical‐resolution photoacoustic microscope enables reflection‐mode 3D imaging with isometric spatial resolution on the micrometer scale. Label‐free volumetric visualizations of adult zebrafish are obtained in vivo. The favorable performance of the proposed sensor offers considerable potential for advancement of biomedical photoacoustic investigations.
Recent Progress on the Rheology of Giant Molecules
Authors: Liu Yuchu , Yan Xiao‐Yun , Guo Qing‐Yun , Lei Huanyu , Liu Xian‐you , Li Xing‐han , Wu Yuean , Zhang Wei , Liu GengXin , Cheng Stephen Z. D. 
Published: November 2022

AbstractGiant molecules are a new class of precise macromolecules whose constructing blocks are molecular nanoparticles, such as polyhedral oligomeric silsesquioxane (POSS), fullerene (C60), etc., connected by different types of links with various molecular topologies in soft matter. These blocks are connected in 3D instead of chain‐like. Thus, the dynamics of giant molecules cannot be described by the entanglement‐dominated “reptation” dynamics, nor by the volume‐fraction‐determined caging effect as in the colloidal domain. Instead, they demonstrate different kinetics which are highly dependent on their sizes (diameters), bridging the conventional polymeric and colloidal systems. Further investigations into its unique dynamics will not only offer new properties for developing novel materials, but will also provide a deeper insight into the general principles of glass formation. In this review, the definition of giant molecules, their assemblies as well as their structural features are first introduced. The general dynamics of other systems, including the conventional polymeric and colloidal systems are briefly summarized. The recent progress of the rheological study of giant molecules is then focused upon. Finally, perspectives on this direction are proposed.
The major pain source of rotator cuff‐related shoulder pain: A narrative review on current evidence
Authors: Lo Chi Ngai , Leung Bernard Pui Lam , Sanders Grant , Li Megan Wai Ming , Ngai Shirley P. C. 
Published: November 2022

AbstractBackgroundRotator cuff‐related shoulder pain (RCRSP) was proposed to have a complex pain mechanism, but the exact aetiology is still unclear. A recent review summarised the updated research to analyse the traditional concept of shoulder impingement which may not be accurate. Current studies have demonstrated that mechanical factors including a reduction in subacromial space, scapular dyskinesia and different acromial shapes are unlikely directly contributing to RCRSP.AimsSince the precise RCRSP pain mechanism remains unclear, the aim of this narrative review is to discuss possible sources of pain contributing to RCRSP according to the mechanisms‐based pain classifications.Results and DiscussionResearch findings on potential mechanical nociceptive factors of RCRSP are conflicting; investigations of neuropathic and central pain mechanisms of RCRSP are limited and inconclusive. Overall, available evidence has indicated moderate to strong correlations between RCRSP and chemical nociceptive sources of pain.ConclusionResults from current research may provide new directions for future studies on the aetiology of RCRSP and its clinical management towards a biochemical view instead of the traditional mechanical hypothesis.
Trendbericht: Chemiedidaktik 2022
Authors: Maaß Mona , Lanfermann Philipp , Habig Sebastian 
Published: November 2022

AbstractNachhaltigkeit, Photochemie und Elektrochemie bleiben im Jahr 2022 die inhaltlichen, Digitalisierung und Modelle die methodischen Schwerpunkte der experimentell‐konzeptionellen Forschung der Chemiedidaktik. Die empirische Forschung evaluiert digitale Lernumgebungen und interessiert sich zunehmend für die Möglichkeiten künstlicher Intelligenz und maschinellen Lernens.
Volumen berechnen – und zwar benutzerfreundlich
Authors: Lavendomme Roy , Maglic Jasmin B. 
Published: November 2022

AbstractMolovol ist ein Programm, das molekulare Volumen, Oberflächen und Hohlräume berechnet. Entwickelt von zwei Chemikern soll es mit Benutzerfreundlichkeit, Funktionalität und Leistung überzeugen. Ein Einblick in die Funktionsweise und Entstehung des Programms.
Liganden nach Maß für sauber getrennte f‐Block‐Elemente
Authors: Urbank Christian , Vondung Lisa 
Published: November 2022

AbstractLanthanoide sind etwa für die Energiewende wichtig, Gadolinium auch als Kontrastmittel für die Kernspintomographie. Von den Actinoiden ist vor allem Uran nützlich, da es als Brennstoff in Kernkraftwerken dient. Allerdings ähneln sich die Eigenschaften der Lanthanoide und Actinoide untereinander so sehr, dass sie nur schwierig zu trennen sind. Hier hilft Ligandendesign.
Recovering orthogonal tensors under arbitrarily strong, but locally correlated, noise
Authors: Mickelin Oscar , Karaman Sertac 
Published: November 2022

SummaryWe consider the problem of recovering an orthogonally decomposable tensor with a subset of elements distorted by noise with arbitrarily large magnitude. We focus on the particular case where each mode in the decomposition is corrupted by noise vectors with components that are correlated locally, that is, with nearby components. We show that this deterministic tensor completion problem has the unusual property that it can be solved in polynomial time if the rank of the tensor is sufficiently large. This is the polar opposite of the low‐rank assumptions of typical low‐rank tensor and matrix completion settings. We show that our problem can be solved through a system of coupled Sylvester‐like equations and show how to accelerate their solution by an alternating solver. This enables recovery even with a substantial number of missing entries, for instance for ‐dimensional tensors of rank with up to missing entries.