bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENTINGNYA KOMPETENSI SUMBER DAYA MANUSIA DAN PENERAPAN APLIKASI SISKEUDES DALAM PENGELOLAAN KEUANGAN DESA (Studi Kasus Pada Kecamatan Lantari Jaya Kabupaten Bombana)
Authors: Asmawati Asmawati , Rahim Manat , Husin Husin 
Published: March 2022

This research aims to test and analyze the importance of human resource competence and the application of siskeudes application in village financial management in Lantari Jaya district of Bombana Regency. Respondents in this study were all apparatus villages that are directly involved in the financial management of the village, which numbered 99 people consisting of the Village Head as technical executor of village financial management (PTPKD), the implementer of village financial management (PPKD) consisting of the Village Secretary, Kaur/Section, and the Village Consultative Agency (BPD) which consists of 5 people, in 9 villages in Lantari Jaya Sub-district. The data analysis used in this study is a WarpPLS analysis technique. The results showed that (1) the competence of the village apparatus had a significant effect on the financial management of the village (2) the application of siskeudes application had a significant effect on the financial management of the village. Keywords: Human Resource Competence, Siskeudes Application, Village Financial Management
PENGARUH BELANJA DAERAH TERHADAP KUALITAS PEMBANGUNAN MANUSIA MELALUI PERTUMBUHAN EKONOMI
Authors: Sutarno Bambang Bintoro , Syarif Muhammad , Ernawati Ernawati 
Published: March 2022

ABSTRAK Tujuan penelitian ini adalah menguji pengaruh langsung belanja daerah dan pengaruh tidak langsung belanja daerah terhadap kualitas pembangunan manusia melalui pertumbuhan ekonomi. Jenis data menggunakan data sekunder yang bersumber dari Badan Pusat Stasitik (BPS) dan Kementerian Keuangan RI. Analisis data menggunakan analisis jalur dengan regresi data panel dengan data cross section 11 Kota di Pulau Sulawesi dan data time series periode 2011-2017.Hasil analisis menunjukkan bahwa belanja daerah berpengaruh signifikan terhadap pertumbuhan ekonomi, namun pertumbuhan ekonomi berpengaruh tidak signifikan terhadap kualitas pembangunan manusia. Hasil penelitian juga menunjukkan belanja daerah berpengaruh langsung terhadap kualitas pembangunan manusia namun tidak dimediasi oleh pertumbuhan ekonomi. Artinya pertumbuhan ekonomi belum dapat memediasi pengaruh belanja daerah terhadap kualitas pembangunan manusia di kota-kota di Pulau Sulawesi periode 2011-2017. Kata Kunci: Belanja Daerah, Pertumbuhan Ekonomi, Kualitas Pembangunan Manusia ABSTRACT English translation. The purpose of this study was to examine the direct effect of regional spending and the indirect effect of regional spending on the quality of human development through economic growth. This type of data uses secondary data sourced from the Central Statistics Agency (BPS) and the Ministry of Finance of the Republic of Indonesia. Data analysis used path analysis with panel data regression with cross-section data from 11 cities in Sulawesi Island and time series data for the 2011-2017 period.The results of the analysis show that regional spending has a significant effect on economic growth, but economic growth has no significant effect on the quality of human development. The results also show that regional spending has a direct effect on the quality of human development but is not mediated by economic growth. This means that economic growth has not been able to mediate the effect of regional spending on the quality of human development in cities on Sulawesi Island for the 2011-2017 period. Keywords: Regional Spending, Economic Growth, Quality of Human Development
PENGARUH UKURAN PERUSAHAAN DAN DISCLOSURE TERHADAP OPINI AUDIT GOING CONCERN (Studi pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Tahun 2015-2019)
Authors: Mariani Mariani Ani , Awaluddin Ishak , Husin Husin 
Published: March 2022

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh ukuran perusahaan dan disclosure terhadap opini audit going concern. penelitian ini merupakan pendekatan kuantitatif karena data yang digunakan berbentuk angka-angka. Penentuan sampel yaitu menggunakan purposive sampling, sehingga sampel berjumlah 34 perusahaan. Teknik analisis data yang digunakan adalah analisis regresi logistik dengan bantuan Software IBM SPSS 26.Berdasarkan hasil penelitian dapat disimpulkan bahwa secara parsial ukuran perusahaan dan disclosure masing – masing berpengaruh signifikan terhadap opini audit going concern. Dan secara simultan ukuran perusahaan dan disclosure bersama-sama berpengaruh signifikan terhadap opini audit going concern, yang dibuktikan dengan nilai chi square sebesar 13,737 dengan tingkat signifikan = 0,001 < 0,10, sehingga hipotesis diterima. Kata Kunci : Ukuran Perusahaan, Disclosure, Opini Audit Going Concern ABSTRACT This study aims to examine and analyze the effect of company size and KAP reputation on going concern audit opinion. This research is a quantitative approach because the data used are in the form of numbers. Determination of the sample is using purposive sampling, so the sample is 34 companies. The data analysis technique used is logistic regression analysis with help of IBM SPSS 26 Software.Based on the result of the study, it can be concluded that in a partially the company size and disclosure are significantly influence to the going concern audit opinion. And the company size and disclosure as same as significantly influence to the going concern audit opinion, that are proven with chi square of 13,737 with a significant value 0,001 < 0,10 then the hypothesis is accepted. Keywords: Company size, Disclosure, Going Concern Audit Opinion.
KINERJA USAHA MIKRO KECIL DAN MENENGAH (UMKM) DI MASA PANDEMI COVID-19 (Studi Pada Rumah Makan dan Restoran di Kota Kendari)
Authors: Samsudin Hasna , Muthalib Abdul Azis , Rosnawintang Rosnawintang 
Published: March 2022

Tujuan penelitian ini untuk menganalisis kinerja restoran dan rumah makan di Kota Kendari selama masa Pandemi Covid 19 di Kota Kendari. Jenis penelitian ini adalah penelitian Kualitatif. informan dalam penelitian ini yaitu rumah makan yang tetap berjalan selama masa pendemi Covid-19. Informan yang akan diwawancarai berjumlah 4 pelaku usaha rumah makan di Kota Kendari. Analisis data yang digunakan dalam penelitian ini adalah deskriptif Kualitatif. Hasil penelitian menunjukkan bahwa selama masa Pandemi Covid 19 terjadi penurukan kinerja penjualan restoran dan rumah makan 50 persen sampai dengan 70 persen. Penurunan tersebut terjadi pada fase awal terjadinya Pandemi Covid 19 di Kota Kendari. Hal tersebut juga berdampak pada penurunan penggunaan tenaga kerja sehingga sebagian tenaga kerja harus dirumahkan.Kata Kunci : Kinerja Rumah Makan Dan Restoran
Impacts of Lesion Characteristics on Procedures and Outcomes of Chronic Total Occlusion Recanalization With Antegrade Guidewire True Lumen Tracking Techniques: A Substudy of Taiwan True Lumen Tracking Registry
Authors: Chang Chi-Jen , Liu Shih-Chi , Tsai Cheng-Ting , Cheng Jen-Fang , Lee Chien-Lin , Lin Chia-Pin , Huang Chi-Hung , Liou Jun-Ting , Wang Yi-Chih , Hwang Juey-Jen 
Published: March 2022

BackgroundLesion characteristics were shown to predict procedural success and outcomes in chronic total occlusion (CTO) recanalization. However, diverse techniques involved in these studies might cause potential heterogeneity.ObjectiveThe study aimed to test the impacts of lesion characteristics on CTO intervention with a pure antegrade wiring-based technique.Methods and ResultsWe studied consecutive 325 patients (64.5 ± 11.1 years, 285 men) with native CTO lesions intervened by a single operator with an antegrade-based technique between August 2014 and July 2020. Forty-seven patients with antegrade procedural failure (20 with pure antegrade wiring failure and 27 with back-up retrograde techniques) were compared to 278 patients with antegrade-only procedural success. With a median follow-up of 30.8 (16.1–48.6) months, 278 patients with procedural success were further assessed for target vessel failure (TVF: cardiac death, target vessel myocardial infarction [MI], and target lesion revascularization [TLR]). Patients with antegrade procedural success had a lower percentage of history with bypass graft (4 vs. 15%, p = 0.004) and lower Multicenter Chronic Total Occlusion Registry of Japan (J-CTO) score (2.1±1.3 vs. 3.4 ± 1.0, p &lt; 0.001), when compared to those with antegrade failure. The J-CTO score was independently associated with procedural failure (odds ratio = 2.5, 95% CI = 1.8–3.4) in multivariate analysis. However, only clinical features, such as female gender (hazard ratio [HR] = 4.3, 95% CI = 1.4–13.1), estimated glomerular filtration rate &lt;60 ml/min/1.73 m2 (HR = 3.2, 95% CI = 1.0–9.9), and old MI (HR = 4.5, 95% CI = 1.5–12.8), but not J-CTO score, could predict long-term TVF in multivariate Cox regression model.ConclusionThe feasibility of the antegrade guidewire-crossing technique for native CTO intervention was highly determined by lesion characteristics. With such a simpler technique, the prognostic impact of lesion complexity shown in studies with multiple recanalization techniques was negligible. This suggested antegrade true lumen tracking techniques deserved to be tried better even for CTO lesions with higher complexity.
Periodontal Inflamed Surface Area Is Associated With Increased Gestational Blood Pressure and Uric Acid Levels Among Pregnant Women From Rural North China
Authors: Hu Shaonan , Yu Feifan , Jiang Hong , Shang Wei , Miao Hui , Li Simin , Zhao Jianjiang , Xiao Hui 
Published: March 2022

BackgroundPeriodontal disease has been associated with gestational complications and both conditions have a high prevalence in rural populations from developing regions. A cross-sectional study was carried out to explore the relationship between periodontal inflamed surface area (PISA), blood pressure (BP), and, serum uric acid levels (UA) in a group of rural North Chinese pregnant women in the third trimester of pregnancy.MethodsThree hundred and thirty-five rural women aged 20–34 years, with normal body mass index (BMI) were examined in a cross-sectional study during their third trimester of gestation. Exclusion criteria were history of pregnancy complications, multiple pregnancy, smoking habits, diabetes, hypertension or any known infectious disease. Socio-demographic variables, including age and socioeconomic status (SES), systolic blood pressure (SBP) and diastolic blood pressure (DBP) readings, serum UA levels, and PISA values were recorded. A structural equation model was implemented with two constructed latent variables including “Dem” (comprising of age and SES category to represent unobserved demographic variables) and, “BP” (comprising of SBP and DBP to account for measurement error and lack of multiple BP readings). The model accounted for co-variance of BP and UA, and implemented simultaneous regressions for BP and UA as outcomes, upon Dem and PISA values as exogenous variables.ResultsThe median PISA score was 1,081.7 (IQR = 835.01), reflecting high levels of periodontal inflammation in the sample. SEM showed a significant association of PISA with BP (estimate = 0.011, 95% CI = 0.009–0.012 p &lt; 0.001) and UA (estimate = 0.001, 95% CI = 0.001–0.001, p &lt; 0.001).ConclusionHigher PISA values were significantly associated with higher blood pressure and uric acid levels among rural pregnant women in a cross-sectional sample from a center in North China after accounting for a latent demographic construct derived from age and SES.
Pore Characterization of Pyrite in the Longmaxi Formation Shale in the Upper Yangtze Area of China
Authors: Chen Xin , Chen Lei , Tan Xiucheng , Wang Chao , Ji Yubing , Xiong Min , Wang Gaoxiang 
Published: March 2022

Pyrite is widely distributed in the Longmaxi marine shale in the Upper Yangtze area of China. Pyrite, one of the important components of shale, has an important influence on the enrichment of shale gas. However, there are currently only a few studies on this topic. Based on shale samples from drilling cores using field emission scanning electron microscopy, the pore characteristics of pyrite from the Longmaxi Formation in the Upper Yangtze area of China are studied. The results showed that the intergranular pores of pyrite and abundant organic pores in the organic matter pyrite assemblages are developed in the Longmaxi Formation shale in the study area. Most pyrite framboid pores have triangular or irregular quadrilateral shapes, with pore diameters ranging from 0 to 240 nm. Pores with diameters of 80–240 nm are the major reservoir spaces for shale gas within the pyrite framboids. The average contribution rate of pyrite framboids to shale pores reaches 3.21%, and the highest contribution is 5.66%, indicating that the pyrite pores may have a favorable contribution to the shale reservoir pore system, but the contribution degree is low.
Incidence of and Risk Factors for Paradoxical Psoriasis or Psoriasiform Lesions in Inflammatory Bowel Disease Patients Receiving Anti-TNF Therapy: Systematic Review With Meta-Analysis
Authors: Xie Wenhui , Xiao Shiyu , Huang Hong , Zhang Zhuoli 
Published: March 2022

BackgroundParadoxical psoriasis or psoriasiform lesions induced by anti-tumor necrosis factor (anti-TNF) therapies receive increasing attention worldwide. However, no comprehensive meta-analysis investigating the incidence estimates and risk factors for anti-TNF-induced psoriasis is currently available. We aimed to precisely quantify its incidence as well as risk factors in patients with inflammatory bowel disease (IBD).MethodsThis study was registered on PROSPERO database under review registration number CRD42021233695. The electronic databases PubMed, EMBASE, and the Cochrane library were comprehensively searched for observational studies published as full-length papers in English and reporting the incidence and/or predictors for psoriasis or psoriasiform lesions in IBD patients. A random-effects meta-analysis was performed to calculate the pooled incidence. Pooled odds ratio (OR) and 95% confidence interval for potential predictors were combined using a fixed-effects or random-effects model.ResultsIn total, 30 articles comprising 24,547 IBD patients treated by anti-TNF were finally included. The overall pooled incidence of psoriasis and/or psoriasiform lesions following anti-TNF therapy was 6.0% (5.0–7.0%; I2 = 93.9%), with 6.9% (5.1–8.7%; I2 = 92.4%) for psoriasiform lesions and 4.6% (3.6–5.6%; I2 = 93.9%) for psoriasis. Multivariable meta-regression analysis indicated regions and populations that significantly contributed to the heterogeneity. A statistically higher risk for psoriasis or psoriasiform lesions during anti-TNF therapy was observed in female patients (OR 1.46, 1.23–1.73), those who are at a younger age at anti-TNF initiation (OR 1.03, 1.00–1.05), smokers (OR 1.97, 1.56–2.48), ileocolonic Crohn’s disease patients (OR 1.48, 1.03–2.13), and those who are using adalimumab or certolizumab (vs. infliximab) (OR: 1.48 and 2.87 respectively).ConclusionsThe incidence of psoriasis or psoriasiform lesions was not uncommon in IBD patients following anti-TNF therapy. Female, younger age, smoker, ileocolonic Crohn’s disease, and the types of anti-TNF were significantly associated with such risk. These findings may help gastroenterologists to make more individualized decisions and understand the mechanisms of this paradoxical phenomenon.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=233695, identifier CRD42021233695.
FAT10 is a Prognostic Biomarker and Correlated With Immune Infiltrates in Skin Cutaneous Melanoma
Authors: Wang Yu , Zhang Haiyue 
Published: March 2022

Background: Skin Cutaneous Melanoma (SKCM) is the deadliest cutaneous neoplasm. Previous studies have proposed ubiquitin-like protein FAT10 plays key roles in the initiation and progression of several types of human cancer, but little is known about the interrelation between FAT10 gene expression, tumor immunity, and prognosis of patients with SKCM.Methods: Here, we first performed pan-cancer analysis for FAT10’s expression and prognosis using the Cancer Genome Atlas and the Genotype-Tissue Expression data. Subsequently, we investigated the mRNA expression level, prognostic value, and gene-gene interaction network of FAT10 in SKCM using the Oncomine databases, GEPIA, TIMER, UALCAN, and starBase. The relationship between FAT10 expression and tumor immune invasion was studied by using the TIMER database. Additionally, the expression and functional status of FAT10 in SKCM were evaluated by the single-cell RNA sequencing and CancerSEA databases.Results: In this study, we found that FAT10 expression was increased in SKCM and was correlated with a better survival rate in patients with SKCM. Moreover, we identified FAT10 level was significantly positively associated with immune infiltrates, biomarkers of immune cells, and immune checkpoint expression, and negatively correlated with tumor cell invasion and DNA damage, indicating that increased FAT10 expression in SKCM was a favorable response to immune checkpoint inhibitors.Conclusion: Our findings suggest that upregulation of FAT10 correlated with better prognosis and tumor immune infiltration in SKCM.
The Longitudinal Association of Subclinical Hearing Loss With Cognition in the Health, Aging and Body Composition Study
Authors: Chern Alexander , Irace Alexandria L. , Sharma Rahul K. , Zhang Yuan , Chen Qixuan , Golub Justin S. 
Published: March 2022

ObjectivesTo examine the longitudinal association between subclinical hearing loss (SCHL) and neurocognitive performance.DesignLongitudinal analyses were conducted among 2,110 subjects who underwent audiometric testing in a US multi-centered epidemiologic cohort study. The primary exposure was better ear hearing (pure tone average). SCHL was defined as hearing ≤ 25 dB. The primary outcome was neurocognitive performance, measured by Digit Symbol Substitution Test (DSST), Modified Mini Mental State Examination (3MS), and CLOX1. Linear mixed models were performed to assess the longitudinal association between hearing and cognitive performance, adjusting for covariates. Models were fit among all individuals and among individuals with SCHL only.ResultsAmong 2,110 participants, mean (SD) age was 73.5 (2.9) years; 52.3% were women. Mean (SD) better ear pure tone average was 30.0 (13.1) dB. Mean follow-up was 9.1 years (range 3–16). Among all participants, worse hearing was associated with significantly steeper cognitive decline measured by the DSST [0.054-point/year steeper decrease per 10 dB worse hearing, 95% confidence interval (CI): 0.026–0.082] and 3MS (0.044-point/year steeper decrease per 10 dB worse hearing, CI: 0.026–0.062), but not CLOX1. Among those with SCHL, worse hearing was associated with significantly steeper cognitive performance decline as measured by DSST (0.121-point/year steeper decrease per 10 dB worse hearing, CI: 0.013–0.228), but not CLOX1 or 3MS.ConclusionAmong those with SCHL, worse hearing was associated with steeper cognitive performance declines over time as measured by DSST. The relationship between hearing loss and cognition may begin at earlier levels of hearing loss than previously recognized.
Association Between Atrial Fibrillation and the Risk of Cardiovascular Mortality Among Elderly Adults With Ischemic Stroke in Northeast China: A Community-Based Prospective Study
Authors: Xia Zhenwei , Dang Wei , Jiang Yang , Liu Shuang , Yue Ling , Jia Fengshuo , Sun Qun , Shi Lei , Sun Jixu , Li Jiao , Chen Hongyun 
Published: March 2022

BackgroundElderly people are susceptible to atrial fibrillation (AF) and ischemic stroke (IS); however, less information is known about the association between AF and the risk of cardiovascular disease (CVD) mortality in elderly population with IS. We aimed to investigate the features of AF among aged people with IS and to illustrate whether AF accounted for CVD mortality.MethodsAt baseline, 790 patients with IS were enrolled from the general northeast Chinese elderly population (&gt;60 years) between September 2017 to March 2019. The prevalence, awareness, and treatment of AF in each age group were analyzed, as well as major-related cardiovascular risk factors. The population was followed until July 31, 2021, and information on CVD death was obtained.ResultsA total of 25 people had AF, and the prevalence of AF in the elderly population with IS was 3.2%. The AF prevalence grew along with age from 1% (60–64 years) to 4.3% (70–74 years) and 4.2% (≥75 years), which was higher in the urban residents than in the rural residents (5.7 vs. 2.2%, P = 0.014). The awareness and treatment rates of patients with AF were 80 and 8%. After a median follow-up period of 3.3 years, 58 subjects died due to CVD and 5 subjects were accompanied with AF (rate 70.6/1,000 person-years). Elderly IS patients with AF had a 3.65-fold increased risk of CVD death in the fully adjusted model when compared with non-AF participants.ConclusionThe AF prevalence increased with age among the elderly population with IS. Moreover, elderly patients with IS in northeast China with AF had a higher CVD mortality. Therefore, early screening and prompt management of AF in elderly population with IS in northeast China are required.
RB1 Is an Immune-Related Prognostic Biomarker for Ovarian Cancer
Authors: Xie Biao , Tan Guangqing , Ren Jingyi , Lu Weiyu , Pervaz Sadaf , Ren Xinyi , Otoo Antonia Adwoa , Tang Jing , Li Fangfang , Wang Yingxiong , Wang Meijiao 
Published: March 2022

BackgroundOvarian cancer (OC) is one of the most lethal gynecologic malignancies and a leading cause of death in the world. Thus, this necessitates identification of prognostic biomarkers which will be helpful in its treatment.MethodsThe gene expression profiles from The Cancer Genome Atlas (TCGA) and GSE31245 were selected as the training cohort and validation cohort, respectively. The Kaplan–Meier (KM) survival analysis was used to analyze the difference in overall survival (OS) between high and low RB transcriptional corepressor 1 (RB1) expression groups. To confirm whether RB1 was an independent risk factor for OC, we constructed a multivariate Cox regression model. Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analyses were conducted to identify the functions of differentially expressed genes (DEGs). The associations of RB1 with immune infiltration and immune checkpoints were studied by the Tumor Immune Estimation Resource (TIMER 2.0) and the Gene Expression Profiling Interactive Analysis (GEPIA). The immunohistochemistry (IHC) was performed to compare the expression level of RB1 in normal tissues and tumor samples, and to predict the prognosis of OC.ResultsThe KM survival curve of the TCGA indicated that the OS in the high-risk group was lower than that in the low-risk group (HR = 1.61, 95% CI: 1.28-2.02, P = 3×10-5), which was validated in GSE31245 (HR = 4.08, 95% CI: 1.21–13.74, P = 0.01) and IHC. Multivariate Cox regression analysis revealed that RB1 was an independent prognostic biomarker (HR = 1.66, 95% CI: 1.31-2.10, P = 2.02×10-5). Enrichment analysis suggested that the DEGs were mainly involved in cell cycle, DNA replication, and mitochondrial transition. The infiltration levels of fibroblast, neutrophil, monocyte and macrophage were positively correlated with RB1. Furthermore, RB1 was associated with immune checkpoint molecules (CTLA4, LAG3, and CD274). The IHC staining revealed higher expression of RB1 in tumor tissues as compared to that in normal tissues (P = 0.019). Overexpression of RB1 was associated with poor prognosis of OC (P = 0.01).ConclusionThese findings suggest that RB1 was a novel and immune-related prognostic biomarker for OC, which may be a promising target for OC treatment.