bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplicación de un cuestionario diagnóstico-evaluativo para medir la psicomotricidad fina por medio de un libro sensorial en preescolar
Authors: García Jiménez Omar , Chavez Cruz Eduardo 
Published: August 2022

La aplicación de los libros sensoriales permite estimular la motricidad fina en los infantes en las primeras etapas de su vida para ir alcanzado las competencias durante el transcurso de su vida. Actualmente en un jardín de niños ubicado el municipio de Ixtapaluca no se está empleando los libros sensoriales para estimular el desarrollo motriz en los niños(as) de primer grado de preescolar, siendo el objetivo de este trabajo medir la psicomotricidad fina de éstos estudiantes por medio de un cuestionario evaluativo conformado por 38 preguntas agrupadas en trece páginas que contiene el libro sensorial para determinar si es necesario o no el empleo de este material didáctico. Los resultados proporcionados por el instrumento indican que se requiere el empleo de un libro sensorial para desarrollar la motricidad fina en los infantes, ya que el puntaje obtenido en cada una de las 38 preguntas se sitúan por debajo de la media teórica que es de 84 puntos, con un rango de valores que oscilan entre los 34 y 46 puntos, representando un área de oportunidad para los docentes que trabajan en ese centro educativo.
Aprendizajes de los maestros de Salamina Caldas sobre su quehacer en tiempos de pandemia
Authors: Cortés Gallego Gustavo Andrés , Giraldo Botero John Alexander , Gómez Quintero Mario Andrés , Castaño García Aracelly 
Published: August 2022

El trabajo investigativo que se presenta tuvo como objetivo comprender los aprendizajes de los maestros de Salamina sobre su quehacer en tiempos de pandemia. Es así como se recurrió a un enfoque de investigación cualitativo de tipo estudio de caso colectivo. Se aplicó un formulario electrónico de única pregunta abierta a 90 maestros de Salamina, Caldas de 4 instituciones educativas: 2 rurales y 2 urbanas. El análisis de la información se efectuó a partir del método de análisis de material cualitativo. Los principales resultados encontrados evidencian la emergencia de 3 categorías: entrega-donación, reflexión práctica y actitudes de aprendizaje. Se concluye que el quehacer del maestro está marcado por las dinámicas sociales del momento. Es decir,en las circunstancias de emergencia sanitaria actuales los maestros de Salamina, a partir de la incertidumbre, tuvieron que adaptarse a las nuevas realidades problematizando elementos cotidianos como su oficio, sus prácticas, y sus habilidades.
A rare case of primary disseminated multi-drug resistant tuberculosis
Authors: Vinod Sushmita , G. Prasanth , V. Gangadharan 
Published: August 2022

Tuberculosis (TB) is the commonest cause of infection-related death globally. Disseminated tuberculosis (TB) is a life-threatening disease which results from the hematogenous spread of Mycobacterium tuberculosis. Genitourinary tuberculosis (GUTB) is usually caused as a result of the hematogenous spread of the mycobacteria during the initial infection. The patient's clinical presentation may vary from asymptomatic to non-specific symptoms related to the organ involved and may also overlap with urinary tract infections caused by other pathogens hence delaying the diagnosis. Here we report one such case where the vague symptoms of the patient and absence of respiratory symptoms delayed the diagnosis of primary disseminated multi-drug resistant (MDR) tuberculosis.
CULTURAL-INDEPENDENT VILLAGE: TOWARDS VILLAGE AUTONOMY IN A CULTURAL AND TOURISM VILLAGE IN YOGYAKARTA
Authors: Supardal  , Triputro Widodo , Pribudi Anggarani 
Published: August 2022

In the context of implementing the privileges of Yogyakarta, Governor Regulation 93 of 2020 concerning Cultural-Independent Villages is stipulated in village development. The concept of a cultural-independent village is described as a village with the characteristics of independence/freedom, sovereignty, integrity, and innovation. The cultural-independent village is a complete and independent model or the political language of an autonomous village. Cultural-independent villages are supported by 4 pillars of independence in the fields of cultural villages, tourism villages, preneur villages, and women's empowering roles. Thus, it is hoped that the culturally independent village will experience economic growth and independence, so that community members can develop their potential, without intervention by the supra-village government. In practice, culturally independent villages are not yet fully independent, because managing the village economy must follow the provisions of the Regional Government Organization (OPD) 4 fields, as well as the budget also depends on privileged funds, the management is facilitated by 2 assistants from the cultural service of the Special Region of Yogyakarta. The problem is that such a development process eliminates a culturally independent village's principle of sovereignty and independence. For this reason, this research will examine the implementation of the principles of a culturally independent village related to developing cultural and tourism villages.
To examine these problems, a qualitative approach was used, to obtain an in-depth picture of the data obtained through in-depth interviews and focus group discussions (FGD) with all culturally independent village stakeholders. For this reason, this research will be located in one of the villages with the title of a culturally independent village. The data is collected, then reduced, and interpreted various phenomena found in-depth so that comprehensive knowledge is obtained on the problems studied.
The results of the study indicate that village autonomy in the context of a culturally independent village within the framework of privileges has not been appropriately implemented, meaning that a culturally independent village has not met the requirements of an autonomous village. This can be seen from the principles of a culturally independent village, namely: sovereignty, freedom, integrity, and innovation which have not been appropriately implemented. In the implementation of the pillars of independent villages, namely cultural villages, tourism villages, preneur villages, and gender roles, the role of the related OPD and cultural village assistants is very dominant, both in budget management and program management. Thus, culturally independent villages do not have the freedom to manage cultural and tourist villages for the community's welfare, because everything has been scheduled by each OPD, especially Kundho Kabudayan in The Special Region of Yogyakarta (DIY).
COVID-19 in chronic liver patients; great danger for cirrhosis patiens
Authors: EBİK Berat , EKİN Nazım , BACAKSIZ Ferhat , KILIC Jihat 
Published: August 2022

Aim: The aim of this study; to investigate the clinical course and mortality of COVID-19 in chronic liver patients with and without cirrhosis and to determine decompensation rates during COVID'19 in cirrhotic patients.
Materials and Methods: 96 patients with chronic liver disease (30 of them cirrhosis) and 153 patients without any comorbid disease were included in this study. It was examined whether there was a difference among these patient groups in terms of severity and mortality of COVID-19.
Results: Severe COVID-19 developed in 46.6% (14/30) cirrhotic patients, in 15.1% (10/66) non-cirrhotic patients, and in 12.4% (19/153) patients with no chronic liver disease (p
Investigation of Interleukin-38 in patients with primary Sjögren’s Syndrome
Authors: GÜLTUNA Selcan , CAN Sevinc , AYDİN Fevzi Nuri 
Published: August 2022

Aim: Interleukin-38 has been involved as an inflammatory mediator in rheumatic diseases. However, little is known about the role of IL-38 in the development of primary Sjögren’s syndrome. The present study aimed to evaluate the role of IL-38 in primary Sjögren’s syndrome and its clinical relevance.
Material and Method:Between 2019 and 2020, 40 patients with primary Sjögren’s syndrome and 39 healthy participants were included in the study. The serum IL-38 level was measured by ELISA in all participants. The serum levels of IL-38 were compared with clinical and laboratory features.
Results:The serum IL-38 levels between the patients with primary Sjögren’s syndrome and the controls were similar (58.0 pg/ml, min-max: 0-641.0 vs. 55.0 ng/ml, min-max: 0-338.0; p=0.511). No significant correlations were found between serum IL-38 level and SSDAI (r=-0.104, p=0.523). IL-38 level was mildly negatively correlated with RF (r=-0.364, p=0.021) and positively correlated with CRP (r=0.321, p= 0.044).
Conclusion:The correlation of IL-38 with CRP and RF should be considered because it might be important clues for contribution to the disease process. IL-38 might be relevant to the heterogeneous nature of PSS and the future role of IL-38 might be a biomarker for specific clinical manifestations of pSS.
Study on Simplified Dynamic Flexible Variable Structure PD Composite Control of Continuous Rotary Motor System Based on Friction Torque Compensation
Authors: wang xiaojing , Feng Yaming , Bai Bocheng 
Published: August 2022

Abstract
Aiming at the influence of uncertain nonlinear factors such as frictional interference on the control performance of the continuous rotary electro-hydraulic servo motor system, the motor system model and its friction torque model are established in this paper. Combined with controllers, genetic algorithm is used for parameter tuning, and a simplified dynamic flexible variable structure PD composite control strategy based on friction feedforward compensation is determined. The simulation and experimental results show that the simplified dynamic flexible variable structure PD composite controller can improve the performance of ultra-low speed and high frequency response of continuous rotary electro-hydraulic servo motor, which has better control accuracy.
Identification of potential biomarkers for colorectal cancer by bioinformatics analysis and analysis of associated survival by Kaplan-Meier curves
Authors: Li Chongyang , Gao Ying , Lu Chunlei , Guo Mingxiao 
Published: August 2022

Abstract
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. A large number of studies have been carried out to elucidate its pathogenesis, but the pathogenesis and molecular mechanisms of CRC remain unclear. Due to the poor clinical outcomes, it is indispensable to investigate novel biomarkers for the diagnosis and prognosis of CRC.Objective: The aim of this study is to explore key genes as potential biomarkers for the diagnosis and prognosis of CRC for clinical utility.Methods: In order to identify and screen candidate genes in CRC carcinogenesis and disease progression, we downloaded microarray datasets GSE89076, GSE73360, GSE32323 from the GEO database, identified differentially expressed genes (DEGs), and performed functional enrichment analysis. A protein-protein interaction network (PPI) was constructed, and correlated module analysis was performed using STRING and Cytoscape. Results: 329 DEGs were identified, including 264 up-regulated genes and 65 down-regulated genes. DEGs' rich functions and pathways include the mitotic cell cycle, DNA damage and replication, chromosome correction, replication fork formation, protein recruitment, and meiosis-related processes. 47 Hub genes were identified, and biological process analysis showed that these genes were mainly enriched in the re-cell division, and during the cell cycle, survival analysis showed that CDK1, PCNA and CCNB1 might be involved in CRC carcinogenesis invasion and recurrence. Conclusion: The hub genes identified in this study contribute to our understanding of the molecular and pathogenic mechanisms of CRC carcinogenesis and progression and provide possible candidate targets for the diagnosis and treatment of CRC.
Topical Nigella Sativa product: A new candidate for the management of diabetic peripheral neuropathy
Authors: Khodaie Seyed-Ali , Nikkhah Haniyeh , Namiranian Nasim , Abotorabi Marzie , Askari Maryam , Khalilzadeh Saeed Hosein , Aghda Amidoddin khatibi , kamalinejad mohammad 
Published: August 2022

Abstract
Background: Diabetic neuropathy is one of the most common complications of diabetes. The synthetic drugs available in the market have side effects and limitations for diabetic patients, the vast majority of whom are in the upper age group. In this regard, based on Persian medicinal sources, Nigella Sativa (N. sativa) has proved to have beneficial effects on nerve-originated pain and neurological disorders. In this study, the effect of N. sativa is investigated topically in patients with diabetic neuropathy, and the results are compared with gabapentin capsules.Method: This study was performed as a double-blind clinical trial on 120 neuropathic patients. The patients were divided into three groups. The first group received a topical N. sativa product as an ointment, the second group was given a topical placebo and the third received 300 mg gabapentin capsules. The blindness was done in first and second groups. The patients were evaluated for eight weeks using the Michigan Response Questionnaire.Results: The data were elicited from the patients' answers to a number of questions in the Michigan questionnaire. There were statistically significant differences between the group that received the topical N. sativa product and the other two groups in terms of legs and feet numbness (p-value = 0.00), burning pain in feet or legs (p-value = 0.00), muscle cramps in feet or legs (p-value = 0.00), prickling fleeing in feet or legs (p-value = 0.00), hurting of the skin when the bed covers touch it (p-value = .005), aggravated symptoms at night (p-value = 0.00) and hurting feelings in the legs when walking (p-value = .0327). However, the three studied groups were not statistically different in distinguishing hot water from cold water.Conclusion: According to the results of this study, the topical use of N. sativa, compared to the current drugs, has acceptable improving effects on diabetic neuropathic patients.
Successful Regression of Newly Formed Corneal Neovascularization by Subconjunctival Injection of Bevacizumab in Patients with Chemical Burns
Authors: Peng Wen-yan , Yin Xiao-fang , Zhou Tao , Zhou Binbing , Zhou Shi-you 
Published: August 2022

Abstract
Purpose: To investigate the effect and timing of subconjunctival bevacizumab injection on inhibiting corneal neovascularization (CNV) in patients after chemical burns.Methods: Patients with CNV secondary to chemical burns were involved. Two subconjunctival injections of bevacizumab (2.5 mg/0.1 mL per involved quadrant) with an interval of four weeks were administered, and followed up a year. The area occupied by neovascular vessels (NA), accumulative neovascular length (NL), mean neovascular diameter (ND), best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were evaluated. Results: Eleven patients with CNV were involved. Eight patients had a history of surgery (four had amniotic grafts, one had keratoplasty, and three had amniotic grafts and keratoplasty). Decreasing in NA, NL, and ND were statistically significant at each time point compared to the baseline (p < 0.01). CNV that developed within one month was considerably regressed, and vessels with fibrovascular membranes were found to be narrower and shorter than pretreatment. BCVA improved in five patients (from one to five lines), remained unchanged in five patients, and decreased in one patient compared to pretreatment.Conclusion: Subconjunctival bevacizumab injection has a particular potential for the regression of CNV, especially within one month in patients after chemical burns.
Determining the Most Effective Way of Intervention in Forest Fires With Fuzzy Logic Modeling: The Case of Antalya/turkey
Authors: Ermiş Temel , Karakoyun Mete Hakan , Awan Muhammad Wasim 
Published: August 2022

Abstract
Forest fires in various parts of the world cause irreversible environmental and economic losses due to the increase in global warming. Determining the risk levels of forest fires is very important in terms of minimizing the negative effects of this fire disaster. In this context, the aim of this study is to mathematically model forest fires from January 2020 to January 2021 in Antalya/Türkiye region with Fuzzy Logic approach. The model has been created with the climatic and topographic characteristics of the region and the Fuzzy Logic approach. The results obtained from the Fuzzy Logic approach have been compared with the real data and it has been shown that the results are 84% compatible in this model. As a result, with the risk assessments to be made thanks to this model, the most effective intervention will be made in a possible forest fire. What we mean by the most effective intervention here is to determine which vehicle group will be used according to the degree of risk of the fire. As a result of all these, a serious contribution will be made to overcome the struggle against a possible forest fire disaster and to ensure the sustainability of nature.MSC Classification: 90C26, 91B30, 91B06, 90C26
Factors influencing the flare of inflammatory markers after drainage of obstruction for patients with obstructive urosepsis
Authors: Huang Baoxing , Lu Guoliang , Tu Weichao , Shao Yuan , Wang Dawei , Xu Danfeng 
Published: August 2022

Abstract
Objective: To analyze risk factors associated with the flare of inflammatory markers after drainage of obstruction for patients with obstructive urosepsis(OUs) and evaluate the laboratory tests for early judgement of patients’ outcome.Methods We conducted a retrospective study including patients with OUs who received surgical decompression of obstruction in our center between February 2017and January 2022.All patients were categorized into two groups based on whether inflammatory markers flare or not after relief of obstruction. Analysis of patients’ characteristics, manner of decompression and laboratory tests were performed. Results A total of 81 patients were enrolled in this study and we identified 43 cases(53.9%) with serum leukocytes flare. The only risk factor for the flare of serum leukocytes in multivariate analyses was shock（OR=9.116,95%CI=3.028-27.438,P＜0.001）. The receiver operating characteristic curve of multivariate model showed an area of 0.796，95%CI 0.699-0.893,P＜0.001. Patients with shock were found to flare significantly more frequently when compared to those without shock for neutrophil (NEUT)（OR=6.324,95%CI=2.103-19.011,P＝0.001）and serum creatinine(Scr)（OR=2.714,95%CI=2.022-3.643,P＝0.009. Outcome analysis suggested that decreased Scr acted as a leading indicator for the early remission of sepsis（n=76，93.8%）.Conclusion The flare of leukocytes after drainage of obstruction may reflect the dysregulated migration of neutrophils caused by severe urosepsis rather than the results of decompressed procedure or exacerbated retrograde infection. Decreased serum creatinine may serve as an ideal predictor for the early detection of remission.
Role of Garbage Classification in Air Pollution Improvement of a Municipal Solid Waste Disposal Base
Authors: Gao Song , Ge Xiang , Li Yuewu , Yang Yong , Duan Yusen , Fu Qingyan , Zhang Shuwei , Yang Xuechun , Jiao Zheng 
Published: August 2022

Abstract
Assessing the impact of garbage classification on air pollution in rapidly developing economic regions is particularly necessary in light of the current policy trends. We evaluated the resulting changes in air pollution levels before and after garbage classification based on a three-year field observation using high-resolution online instruments in a municipal solid waste comprehensive disposal base. A new method is proposed to quantify the impact of major sources in a complex multi-source environment. We found that the concentrations of hydrogen sulfide (H2S) and volatile organic compounds (VOCs) in ambient air decreased by 48% and 43% respectively after garbage classification, and their spike frequency was controlled at approximately 0.01. The average H2S and VOC concentrations were generally low during the daytime, but relatively high during the nighttime because of meteorology and photochemistry. The ozone formation potential of the base decreased by 56%. Alternatively, emissions from transportation and combustion sources increased, while landfill pollution decreased owing to changes in the method of waste disposal. This finding suggests that garbage classification is an effective means of improving the air quality. This new quantification method has a good potential in actual research scenarios.
Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats.
Authors: Maksymiuk Klaudia , Szudzik Mateusz , Kopczyńska Marta Gawryś - , Onyszkiewicz Maksymilian , Samborowska Emilia , Mogilnicka Izabella , Ufnal Marcin 
Published: August 2022

Abstract
Background
trimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine (TMA), a product of gut microbiota and manufacturing industries-derived pollutant, by flavin monooxygenases (FMOs). The effect of chronic exposure to TMA on cardiovascular and renal systems is undetermined.
Methods
metabolic, hemodynamic, echocardiographic, biochemical and histopathological evaluations were performed in 12-week-old male SPRD rats receiving water (controls) or TMA (200 or 500 µM/day) in water for 18 weeks. TMA and TMAO levels, the expression of FMOs and renin-angiotensin system (RAS) genes were evaluated in various tissues.
Results
in comparison to controls, rats receiving TMA had significantly increased arterial blood pressure, urine protein to creatinine ratio, urine KIM-1 levels, and hypertrophy of the tunica media of arteries and arterioles. Mild degeneration of renal bodies with glomerulosclerosis was also observed. There was no significant difference between the three groups in body weight, water-electrolyte balance, echocardiographic parameters and RAS expression. TMA groups had marginally increased 24hr TMA urine excretion, whereas serum levels and 24hr TMAO urine excretion were increased up to 24-fold, and significantly increased TMAO levels in the liver, kidneys and heart. TMA groups had lower FMOs expression in the kidneys.
Conclusions
chronic exposure to TMA increases blood pressure and increases markers of kidney damage, including proteinuria and KIM-1. TMA is rapidly oxidized to TMAO in rats, which may limit the toxic effects of TMA.