bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transverse seismic response of end‐bearing pipe piles to S‐waves
Authors: Zheng Changjie , Luo Tong , Kouretzis George , Ding Xuanming , Luan Lubao 
Published: May 2022

AbstractThis paper presents a method for the seismic analysis of open‐ended pipe piles subjected to vertically propagating S‐waves, that considers kinematic interaction between the pipe pile and its external and internal soil. Following the presentation of the elastodynamic continuum model, which is based on the assumptions of linear elastic soil response and uniform soil conditions, we employ the derived solution to investigate the sensitivity of the seismic response of pipe piles to certain key problem parameters, such as pile slenderness or the relative stiffness of the pipe pile compared to its surrounding soil. We demonstrate that the bending stiffness of pipe piles is governing their seismic response, and that thin‐walled pipe piles offer the best material usage versus seismic performance ratio. The presented solution offers a low‐cost alternative to complex numerical simulations for preliminary seismic design purposes, such as the selection of optimal pipe pile section geometry.
Ca doping to enhance energy storage performance of lead‐free SrTi0.99Mn0.01O3 thin films with low hysteresis
Authors: Wang Zhenyu , Zhang Yulei 
Published: May 2022

AbstractDielectric materials with excellent energy storage performance are urgently needed in advanced electrical power systems. We have reported that Mn2+‐doped SrTiO3 thin films have high energy storage density. However, the thin films exhibit fat polarization‐electric field hysteresis loops with high hysteresis, which is not conducive to greater energy storage performance. In this work, the Ca2+‐doped Sr1‐xCaxTi0.99Mn0.01O3 thin films are fabricated to construct slim polarization‐electric field hysteresis loops with low hysteresis for obtaining excellent energy storage performance. Because Ca2+ can break the long‐range ferroelectric order of SrTi0.99Mn0.01O3, the domain size decreases and the coupling of domains weakens, ultimately leading to low hysteresis. Moreover, doping Ca2+ can induce distortion of the octahedral [TiO6] to form local polarization regions. When doped an appropriate amount of Ca2+, local lattice distortion plays an important role in polarization behavior, which helps to enhance polarization. Meanwhile, the Ca2+‐doped thin films also possess good insulation. Finally, the higher energy storage density of 63.9 J cm‐3 is achieved in the Sr0.9Ca0.1Ti0.99Mn0.01O3 thin film. When the electric field is less than 4000 kV cm‐1, the energy storage efficiency remains above 70%. Simultaneously, a wide working temperature range from ‐100℃ to 100℃ is also obtained.
Blood donors' usage intentions of donation appointment‐scheduling systems during the COVID‐19 pandemic and beyond
Authors: Saltzmann Carolin , Boenigk Silke 
Published: May 2022

AbstractDuring the COVID‐19 pandemic, online appointment‐scheduling systems have become standard procedure in blood donation practice. This study develops and empirically tests a comprehensive conceptual model of blood donors' usage intentions of a donation appointment‐scheduling system during the COVID‐19 pandemic. Online survey data are collected from blood donors (n = 3269) and analyzed using the partial least squares structural equation modeling (PLS‐SEM) approach. The results provide evidence that intentions to use the system in the post‐COVID‐19 future are high. Together with high‐perceived usefulness and ease of use, this indicates generally high‐system acceptance among active donors during the pandemic and beyond. The study identifies a number of factors that influence this acceptance. The results show that different aspects of service quality perceptions in the context of the system drive its acceptance. The strongest positive effect is exerted by blood donors' pre‐donation planning convenience, followed by an enhanced actual donation experience. Reduced flexibility as a result of the system has a strong negative effect. The authors derive managerial implications for blood donation services regarding preserving the acceptance level and suggest future research prospects.
Scientific response to a cluster of shark bites
Authors: Barnett Adam , Fitzpatrick Richard , Bradley Michael , Miller Ingo , Sheaves Marcus , Chin Andrew , Smith Bethany , Diedrich Amy , Yick Jonah Lee , Lubitz Nicolas , Crook Kevin , Mattone Carlo , Bennett Mike B. , Wojtach Leah , Abrantes Kátya 
Published: May 2022

Abstract

Shark bites are of high public concern globally. Information on shark occurrence and behaviour, and of the effects of human behaviours, can help understand the drivers of shark‐human interactions. In Australia, a number of shark bite clusters occurred over the last decade. One of these took place in Cid Harbour the Whitsundays, Queensland, a region for which little was known about the shark community. Here, we describe and evaluate the research in response to that shark bite cluster.

Fishing methods, acoustic and satellite tracking, and baited remote underwater video cameras (BRUVs) were used to identify the shark species using Cid Harbour, estimate relative abundance, and describe habitat use and residency. Side‐scan sonar and BRUVs were also used to assess prey availability. Recreational users were surveyed to understand human behaviour and their awareness and perceptions of ‘Shark Smart’ behaviours. This allowed shark occurrence and behaviour to be interpreted in the context of human behaviours in the Harbour.

Eleven shark species were identified. Relative abundance was not unusually high, and residency in Cid Harbour was typically low. For example, 79% of acoustically tagged sharks visited the harbour on <10% days at liberty. Shark prey was available year‐round. Notably, anchored boats regularly conduct activities that can attract sharks (dumping food scraps, provisioning and cleaning fish).

Alone, the methods used in this study had variable success, but combined they provided a large amount of complementary information. Including a social science component in the research response to the shark bite incidents allowed for a more holistic understanding of the Cid Harbour bite incidents.

This study did not identify anything unusual about the shark community that could have contributed to the Cid Harbour shark bite cluster. However, the three incidents involved people bitten almost instantly after entering the water, which is unusual and suggests that feeding/attracting sharks to boats could have been a contributor and also that any species capable of biting humans could have been responsible.

The eradication of activities that attract sharks to areas where people enter the water may reduce shark bite risk.
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FDA approval summary: Crizotinib for pediatric and young adult patients with relapsed or refractory systemic anaplastic large cell lymphoma
Authors: Merino Margret , Kasamon Yvette , Li Hongshan , Ma Lian , Leong Ruby , Zhou Jiaxi , Reaman Gregory , Chambers Wiley , Richardson Nicholas , Theoret Marc , Pazdur Richard , Gormley Nicole 
Published: May 2022

AbstractIn January 2021, the U.S. Food and Drug Administration (FDA) approved crizotinib for pediatric patients 1 year and older and young adults with relapsed or refractory systemic anaplastic large cell lymphoma (sALCL). This is the first approval for pediatric sALCL. Approval was based on a single‐arm trial of crizotinib monotherapy that included 26 patients, aged 1–20 years, with previously treated sALCL. Efficacy was based on centrally assessed objective response rate (88%) and duration of response. Herein, we highlight unique aspects of the regulatory review, including extension of the indication to young adults, postmarketing safety, and dose optimization strategies.
Mathematical models for the use, processing, and optimized utilization of natural arc‐shaped bamboo laminated lumber
Authors: Huang Bin , Fang Changhua , Chen Lin , Fei Benhua 
Published: May 2022

AbstractThe natural arc‐shaped bamboo laminated lumber (ABLL) maintained the natural structure of bamboo material. It had significance for its various applications in bamboo industry. This article took the thickness (T) and width (W) of the ABLL as the research object. The first mathematical model determined the relationship among the size of the bamboo tubes, the number of divisions and the thickness (T) of the ABLL. In order to avoid forming incomplete arc‐shaped bamboo corners during the process of sawing of ABLL into square lumber, we used Mathlab analysis to obtain the appropriate numbers of divisions were 4–6 parts. Moreover, the thickness (T) of ABLL was found to be 37–62 mm. The second mathematical model determined the relationship between the size of the equal‐arc shaped bamboo split and the width (W) of ABLL. The proposed mathematical models provided a grading basis for the material selection in the processing of ABLL, optimized the utilization of bamboo, and was of great significance for high‐quality preparation of ABLL.
Two‐stage subgroup‐specific time‐to‐event (2S‐Sub‐TITE): An adaptive two‐stage time‐to‐toxicity design for subgroup‐specific dose finding in phase I oncology trials
Authors: McGovern Alana , Chapple Andrew G. , Ma Clement 
Published: May 2022

AbstractFor phase I trials, the subgroup‐specific time‐to‐event (Sub‐TITE) design identifies the maximum tolerated dose (MTD) separately in 2+ heterogeneous patient subgroups. Sub‐TITE allows borrowing strength and dynamic clustering across subgroups from the trial's start, but delaying the initiation of borrowing and clustering may improve trial accuracy. We propose the 2‐stage Sub‐TITE (2S‐Sub‐TITE) design in which the trial starts by estimating separate models per subgroup, and then initiates the Sub‐TITE design at some pre‐specified point of patient accrual. We evaluate the operating characteristics of the 2S‐Sub‐TITE design using simulations. Nine configurations of the 2S‐Sub‐TITE design (varying in timing of initiation of borrowing/clustering and prior probability of subgroup heterogeneity, p_hetero) and three control methods were compared across 1000 randomly‐generated true toxicity probability scenarios. Effects of priors, sample size, escalation rules, target toxicity probability, accrual rate, and number of subgroups were evaluated. Metrics included: proportion of correct selection (PCS) of the true MTD, and average number of toxicities incurred. Among the 5 2S‐Sub‐TITE configurations (out of 9 total) with the highest PCS (45%) when the subgroup heterogeneity assumption is correct (all of which out‐perform the control methods by 2%–6%), the configuration which enables borrowing and clustering allowance with p_hetero = 0.7 starting at 75% patient accrual best minimizes toxicities as well as losses in accuracy if the heterogeneity assumption is incorrect. For trials with high confidence in subgroup heterogeneity, the 2S‐Sub‐TITE configuration enabling borrowing/clustering with p_hetero = 0.7 starting at 75% patient accrual exhibits superior dose‐finding accuracy compared to existing methods.
Hyperoside: A review on its sources, biological activities, and molecular mechanisms
Authors: Wang Qi , Wei Hao‐Cheng , Zhou Sheng‐Jun , Li Ying , Zheng Ting‐Ting , Zhou Chang‐Zheng , Wan Xin‐Huan 
Published: May 2022

AbstractHyperoside is a natural flavonol glycoside in various plants, such as Crataegus pinnatifida Bge, Forsythia suspensa, and Cuscuta chinensis Lam. Medical research has found that hyperoside possesses a broad spectrum of biological activities, including anticancer, anti‐inflammatory, antibacterial, antiviral, antidepressant, and organ protective effects. These pharmacological properties lay the foundation for its use in treating multiple diseases, such as sepsis, arthritis, colitis, diabetic nephropathy, myocardial ischemia–reperfusion, pulmonary fibrosis, and cancers. Hyperoside is obtained from the plants and chemical synthesis. This study aims to provide a comprehensive overview of hyperoside on its sources and biological activities to provide insights into its therapeutic potential, and to provide a basis for high‐quality studies to determine the clinical efficacy of this compound.
Command‐filter‐based adaptive output feedback quantized tracking control for switched stochastic nonlinear time‐delay systems with actuator saturation
Authors: Wu Tiantian , Yang Yekai , Li Shugang , Yu Zhaoxu 
Published: May 2022

AbstractThis work addresses the adaptive output feedback quantized control for a class of switched stochastic nonstrict‐feedback nonlinear time‐delay systems with input and output quantization and actuator saturation under arbitrary switching. A novel state observer including the quantized output signal and the saturated input signal is designed to estimate the unknown system states. Then, the command‐filtered backstepping method is introduced to avoid the “explosion of complexity” in the adaptive backstepping recursive design. Moreover, the design challenges from input and output quantization errors and actuator saturation are overcome by combining the auxiliary variable approach and some special techniques. Instead of the traditional quartic Lyapunov–Krasovskii functional, the common quadratic Lyapunov–Krasovskii functional is constructed to develop the adaptive quantized tracking control scheme for such systems. By means of the proposed common controller independent of switching signal, all closed‐loop signals are mean‐square semi‐globally uniformly ultimately bounded, while the tracking error will remain in a small neighborhood of the origin. Finally, stability analysis and simulation results are provided to show the effectiveness and performance of the proposed design methodology.
Rational Regulation of Crystalline/Amorphous Microprisms‐Nanochannels Based on Molecular Sieve (VSB‐5) for Electrochemical Overall Water Splitting
Authors: Zhao Jiayang , Zhang Yao , Guo Haoran , Zhang Haotian , Ren Junkai , Song Rui 
Published: May 2022

AbstractRational regulation of the composition and structure of electrocatalysts is crucial to the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Herein, a new electrocatalyst of nickel phosphate microprism (VSB/NiPO) is developed via a simple solvothermal reaction. The microprism is mainly composed of Versailles‐Santa Barbara‐5 (VSB‐5, molecular sieve) with unique nanochannels, which contribute to accelerating mass transfer and exposing more active sites, thus displaying excellent HER activity. Subsequently, the crystallinity and electronic structure of the framework are modulated by incorporating Fe with the combination of calcination and impregnation. The nanochannels are converted to the amorphous arrangement, and the Ni centers are regulated to the higher valence. The resultant Fe‐VSB/NiPO‐500 exhibits a low OER overpotential of 227 mV at 50 mA cm−2. Interestingly, an integrated electrolyzer assembled by VSB/NiPO(−) and Fe‐VSB/NiPO‐500(+) performs well for overall water splitting, which requires only 1.487 V to achieve 10 mA cm−2, and remains stable at 100 mA cm−2 over 100 h. This finding opens a new avenue for developing VSB‐5 in the field of electrocatalysis.
Transient Solid‐State Laser Activation of Indium for High‐Performance Reduction of CO2 to Formate
Authors: Guo Weihua , Zhang Yuefeng , Su Jianjun , Song Yun , Huang Libei , Cheng Le , Cao Xiaohu , Dou Yubing , Ma Yangbo , Ma Chenyan , Zhu He , Zheng Tingting , Wang Zhaoyu , Li Hao , Fan Zhanxi , Liu Qi , Zeng Zhiyuan , Dong Juncai , Xia Chuan , Tang Ben Zhong , Ye Ruquan 
Published: May 2022

AbstractDeficiencies in understanding the local environment of active sites and limited synthetic skills challenge the delivery of industrially‐relevant current densities with low overpotentials and high selectivity for CO2 reduction. Here, a transient laser induction of metal salts can stimulate extreme conditions and rapid kinetics to produce defect‐rich indium nanoparticles (L‐In) is reported. Atomic‐resolution microscopy and X‐ray absorption disclose the highly defective and undercoordinated local environment in L‐In. In a flow cell, L‐In shows a very small onset overpotential of ≈92 mV and delivers a current density of ≈360 mA cm‐2 with a formate Faradaic efficiency of 98% at a low potential of −0.62 V versus RHE. The formation rate of formate reaches up to 6364.4 µmol h‐1 , which is nearly 39 folds higher than that of commercial In (160.7 µmol h‐1 ), outperforming most of the previous results that have been reported under KHCO3 environments. Density function theory calculations suggest that the defects facilitate the formation of *OCHO intermediate and stabilize the *HCOOH while inhibiting hydrogen adsorption. This study suggests that transient solid‐state laser induction provides a facile and cost‐effective approach to form ligand‐free and defect‐rich materials with tailored activities.
Photoactivated Organic Nanomachines for Programmable Enhancement of Antitumor Efficacy
Authors: Huang Xing , Liu Yang , Feng Ao , Cheng Xie , Xiong Xiangyu , Wang Zimo , He Zhaoxia , Guo Jintang , Wang Shuai , Yan Xibo 
Published: May 2022

AbstractLimited permeability in solid tumors significantly restricts the anticancer efficacy of nanomedicines. Light‐driven nanomotors powered by photothermal converting engines are appealing carriers for directional drug delivery and simultaneous phototherapy. Nowadays, it is still a great challenge to construct metal‐free photothermal nanomotors for a programmable anticancer treatment. Herein, one kind of photoactivated organic nanomachines is reported with asymmetric geometry assembled by light‐to‐heat converting semiconducting polymer engine and macromolecular anticancer payload through a straightforward nanoprecipitation process. The NIR‐fueled polymer engine can be remotely controlled to power the nanomachines for light‐driven thermophoresis in the liquid media and simultaneously thermal ablating the cancer cells. The great manipulability of the nanomachines allows for programming of their self‐propulsion in the tumor microenvironment for effectively improving cellular uptake and tumor penetration of the anticancer payload. Taking the benefit from this behavior, a programmed treatment process is established at a low drug dose and a low photothermal temperature for significantly enhancing the antitumor efficacy.
Freestanding 3D Metallic Micromesh for High‐Performance Flexible Transparent Solid‐State Zinc Batteries
Authors: Chen Tianwei , Shuang Zhengwen , Hu Jin , Zhao YanLi , Wei Donghai , Ye Jinghua , Zhang Guanhua , Duan Huigao 
Published: May 2022

AbstractFlexible transparent energy supplies are extremely essential to the fast‐growing flexible electronic systems. However, the general developed flexible transparent energy storage devices are severely limited by the challenges of low energy density, safety issues, and/or poor compatibility. In this work, a freestanding 3D hierarchical metallic micromesh with remarkble optoelectronic properties (T = 89.59% and Rs = 0.23 Ω sq−1) and super‐flexibility is designed and manufactured for flexible transparent alkaline zinc batteries. The 3D Ni micromesh supported Cu(OH)2@NiCo bimetallic hydroxide flexible transparent electrode (3D NM@Cu(OH)2@NiCo BH) is obtained by a combination of photolithography, chemical etching, and electrodeposition. The negative electrode is constructed by electrodeposition of electrochemically active zinc on the surface of Ni@Cu micromesh (Ni@Cu@Zn MM). The metallic micromesh with 3D hierarchical nanoarchitecture can not only ensure low sheet resistance, but also realize high mass loading of active materials and short electron/ion transmission path, which can guarantee high energy density and high‐rate capability of the transparent devices. The flexible transparent 3D NM@Cu(OH)2@NiCo BH electrode realizes a specific capacity of 66.03 μAh cm−2 at 1 mA cm−2 with a transmittance of 63%. Furthermore, the assembled solid‐state NiCo‐Zn alkaline battery exhibits a desirable energy density/power density of 35.89 μWh cm−2/2000.26 μW cm−2 with a transmittance of 54.34%.
Fermi‐Level Depinning in Metal/Ge Junctions by Inserting a Carbon Nanotube Layer
Authors: Wei Yu‐Ning , Hu Xian‐Gang , Zhang Jian‐Wei , Tong Bo , Du Jin‐Hong , Liu Chang , Sun Dong‐Ming , Liu Chi 
Published: May 2022

AbstractGermanium (Ge)‐based devices are recognized as one of the most promising next‐generation technologies for extending Moore's law. However, one of the critical issues is Fermi‐level pinning (FLP) at the metal/n‐Ge interface, and the resulting large contact resistance seriously degrades their performance. The insertion of a thin layer is one main technique for FLP modulation; however, the contact resistance is still limited by the remaining barrier height and the resistance induced by the insertion layer. In addition, the proposed depinning mechanisms are also controversial. Here, the authors report a wafer‐scale carbon nanotube (CNT) insertion method to alleviate FLP. The inserted conductive film reduces the effective Schottky barrier height without inducing a large resistance, leading to ohmic contact and the smallest contact resistance between a metal and a lightly doped n‐Ge. These devices also indicate that the metal‐induced gap states mechanism is responsible for the pinning. Based on the proposed technology, a wafer‐scale planar diode array is fabricated at room temperature without using the traditional ion‐implantation and annealing technology, achieving an on‐to‐off current ratio of 4.59 × 104. This work provides a new way of FLP modulation that helps to improve device performance with new materials.
Diffusion tensor imaging of fetal brain: principles, potential and limitations of promising technique
Authors: Corroenne R. , Arthuis C. , Kasprian G. , Mahallati H. , Ville Y. , Millischer Bellaiche A.‐E. , Henry C. , Grevent D. , Salomon L. J. 
Published: May 2022

AbstractHuman brain development is a complex process that begins in the third week of gestation. During early development, the fetal brain undergoes dynamic morphological changes. These changes result from events such as neurogenesis, neuronal migration, synapse formation, axonal growth and myelination. Disruption of any of these processes is thought to be responsible for a wide array of different pathologies.Recent advances in magnetic resonance imaging, especially diffusion‐weighted imaging and diffusion tensor imaging (DTI), have enabled characterization and evaluation of brain development in utero.In this review, aimed at practitioners involved in fetal medicine and high‐risk pregnancies, we provide a comprehensive overview of fetal DTI studies focusing on characterization of early normal brain development as well as evaluation of brain pathology in utero. We also discuss the reliability and limitations of fetal brain DTI. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
Treatment of an extrahepatic portosystemic shunt by placement of a hydraulic occluder followed by a thin film band in a dog: An eventful story
Authors: Bondel Margaux , Morvan Victor , Moissonnier Pierre 
Published: May 2022

AbstractA 1‐year‐old, female, Yorkshire terrier was evaluated for two episodes of disorientation and severe depression. A portosystemic shunt was suspected based on clinical signs and biochemical analysis, and further confirmed by computed tomography angiography. After initial stabilisation with medical treatment, the dog underwent surgery. Invasive measurement of portal pressure after temporary complete shunt occlusion revealed a very high pressure of 40 mmHg, motivating placement of a hydraulic occluder. Several complications occurred in the postoperative period, including kinking of the device, necessitating removal of the hydraulic occluder in emergency; development of signs of portal hypertension during inflation of the hydraulic occluder, requiring partial balloon deflation; and persistent shunting, which was managed by replacing the hydraulic occluder by a thin film band.