bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Peripherally Inserted Central Catheter is as Useful as a Central Venous Catheter for Rapid Fluid Infusion
Authors: Maki Jun , Sumie Makoto , Ide Tomoko , Nagamatsu Masako , Matsushita Katsuyuki , Shirozu Kazuhiro , Higashi Midoriko , Yamaura Ken 
Published: February 2022

Abstract
Background
Peripherally inserted central catheters (PICCs) have been widely used because of their low risk of mechanical complications associated with insertion compared with central venous catheters (CVCs). However, PICCs are not widely used for anesthetic management due to concerns regarding the measurement of central venous pressure (CVP) and rapid fluid infusion. The CVP measured via PICCs are reportedly as accurate as that measured via CVC, but the findings concerning rapid infusion are unclear. We therefore investigated the usefulness of a PICC as a rapid infusion route compared with a CVC.
Methods
The in-line pressure was measured in similar-sized double-lumen catheters - 4-Fr PICC (55, 45 and 35 cm) and 17-G CVC (13 and 20 cm) - at flow rates of saline decided using a roller pump system. We also examined the flow rate at an in-line pressure of 300 mmHg, which is the critical pressure at which hemolysis is considered to occur during blood transfusion.
Results
In-line pressures increased in proportion to the flow rate and catheter length in both the PICC and CVC. On comparing the 45-cm PICC and 20-cm CVC, the in-line pressures were higher in the PICC than in the CVC at a flow rate of ≤30 mL/min, although the opposite was true at a flow rate of ≥90 mL/min. Flow rates at an intra-circuit pressure of 300 mmHg were not significantly different between the 45-cm PICC and 20-cm CVC.
Conclusion
A PICC can be used for rapid fluid infusion and blood transfusion, just like a CVC.
Using Patient Flow Analysis with Real-Time Patient Tracking to Optimize Radiation Oncology Consultation Visits
Authors: Mesko Shane , Weng Julius , Das Prajnan , Koong Albert C. , Herman Joseph M. , Elrod-Joplin Dorothy , Kerr Ashley , Aloia Thomas , Frenzel John , French Katy E. , Martinez Wendi , Recinos Iris , Alshaikh Abdulaziz , Daftary Utpala , Moreno Amy C. , Nguyen Quynh-Nhu 
Published: February 2022

Abstract
Purpose: Clinical efficiency is a key component of the value-based care model and a driver of patient satisfaction. The purpose of this study was to identify and address inefficiencies at a high-volume radiation oncology clinic.Methods and Materials: Patient flow analysis (PFA) was used to create process maps and optimize the workflow of consultation visits in a gastrointestinal radiation oncology clinic at a large academic cancer center. Metrics such as cycle times, waiting times, and rooming times were compared before vs after implementation of the PFA recommendations by using a real-time patient status function in the electronic medical record for 556 consults. Results: The initial PFA revealed four inefficiencies: (1) protracted rooming time, (2) inefficient communications, (3) duplicated tasks, and (4) ambiguous clinical roles. We analyzed 485 consult-visits before the PFA and 71 after the PFA. The PFA recommendations led to reductions in overall median cycle time by 21% (91 min vs 72 min, p<0.001), in cumulative waiting times by 64% (45 min vs 16 min; p<0.001), which included waiting room time (14 min vs 5 min; p<0.001); and wait for physician (20 min vs. 6 min; p<0.001). Slightly less than one-quarter (22%) of consult visits before the PFA lasted >2 hours vs. 0% after implementation of the recommendations (p<0.001). Similarly, the proportion of visits requiring <1 hour was 16% before PFA vs 34% afterward (p<0.001). Conclusions: PFA can be used to identify clinical inefficiencies and optimize workflows in radiation oncology consultation clinics, and implementing their findings can significantly improve cycle times and waiting times. Potential downstream effects of these interventions include improved patient experience, decreased staff burnout, financial savings, and opportunities for expanding clinical capacity.
Pharmacokinetics and Molecular Docking for Identification of Potential Drug Targets in Tangeretin’s Neuro-Protection
Authors: Balasubramani Sundararajan , Rasu Arulkumar , Venuvanalingam Ponnambalam , Zhou Zhiqin 
Published: February 2022

Abstract
Background
Tangeretin obtained from Citrus limonum L. represents the key secondary metabolite amongst other citrus derived polymethoxyflavones eliciting a comprehensive bioactive potential establishing versatility in abating neurodegenerative disorders.
Objective
The present study was aimed to decipher additional targets and interacting mechanisms for tangeretin in elucidating the neuro-inflammatory profiles through computer aided drug designing and deciphering potential molecular mechanisms.
Methods
Pharmacokinetic evaluation waswill be performed for ADMET properties comprising Liver Toxicity, Metabolism, blood brain barrier permeability, cardiotoxicity, mitochondrial toxicity, mutagenicity by vNN web server and SWISS-ADME for drug likeliness deriving medicinal properties of tangeretin, comparatively. Polar surface area-based drug assimilatory profiles were catalogued using Molinspiration toolkit for confirming the tangeretin’s bioavailibility and solubility. Extra-precision flexible molecular docking studies was preceded using Glide XP incorporated in Schrödinger, LLC, New York, NY, 2021 for protein (5-Beta-reductase, PLA2, IRAK4, COX-1, COX-2, 5-LOX, NIK) – ligand (tangeretin) interaction assessment. Phylogenetic analysis of the selected protein targets in docking experiments were assessed for closely relatedness by maximum likelihood iterations using MEGA 10.2.6. Further tangeretin-gene targets-interaction assessment was cross-verified in STITCH and SWISSTARGET prediction data for affirming putative drug targets.
Results
Pharmaokinetic assessment revealed the tangeretin’s role in safety, efficacy and druglike properties based on chemi-informatic profiles. Further selected proteins utilized for flexible docking corresponds to 3KK6, 1CX2 (Cyclooxygenases family), 2B03 (Phospholipase A2), 4IDV (NF-KB-inducing kinase), 6O9D (Interleukin-1 receptor-associated kinase domain) and 3BV7 (steroid 5beta-reductase) that were assessed for binding affinity patterns revealed the efficacy in the order of 5-Beta-reductase > PLA2 > IRAK4 > COX-1 > COX-2 > 5-LOX > NIK. Phylogenetic relatedness proved that 3BV7 posed the ancestral node for rest of the selected proteins emphasizing cascade mechanisms in absorption potentiating additional protein-protein interaction and crosstalk. Comparative gene target analysis revealed two putative potential targets namely AKT1 and CYP1A1.
Conclusion
Pharmacokinetic based docking assessment and network pharmacology studies pertaining neuro-inflammatory protection are coerced with confirmation of putative targets aiding the safety, efficacy, and efficiency of tangeretin.
Clinical Investigation Of Use Of Episil® Oral Solution In Oral Mucositis During Radiotherapy For Head And Neck Cancer
Authors: Kabasawa Yuji , Ito Kanade , Tokura Shiori , Takazawa Itsuki , Yoshida Naomi , Nakanishi Tohko , Akiyama Kikue , Onuma Yuki , Adachi Toshiko , Harada Hiroyuki , Nojima Hitomi , Miura Masahiro , Yoshimura Ryoichi 
Published: February 2022

Abstract
Objective: Episil® is a bioadhesive barrier-forming oral liquid gel that has been used in recent years to relieve pain at the onset of oral mucositis (OM) associated with radiotherapy (RT) or chemoradiotherapy (CRT) in patients with head and neck cancer (HNC). We retrospectively analyzed the clinical effect of Episil® on OM in patients with HNC who underwent RT or CRT. Patients and Methods: A total of 65 patients with HNC were treated with RT or CRT at our hospital between June 2018 and May 2020. Among the 65 tumors, 64 were histologically confirmed as squamous cell carcinomas, and one malignant lymphoma. Results: The median total RT dose was 50 Gy (range, 30–70 Gy) and the completion rate of RT was 63/65 (97%). The median time to OM resolution was 47 (6–90) days and was significantly longer (53 [27–90] days) when the total RT dose was ³51 Gy (p<0.001). Episil® was used in 26 patients; among them, 10 of whom discontinued its use due to several factors including ineffective pain relief, usage difficulties, and taste intolerance. The median duration of use was 30 (1–52) days and was significantly longer (34.5 [10–52] days) (p<0.001) when patients experienced pain relief at treatment initiation. Conclusion: Although Episil® has been shown to be effective in improving the pain of OM caused by RT of HNC patients. Episil® needs to be improved, and medical professionals are required to give careful attention to each individual patient.
Strategies for maintaining and improving clinical credibility of nursing lecturers: A meta-synthesis study
Authors: soodmand parvaneh , Mohsenizadeh Seyyed Mostafa , Meshkinyazd Ali , akhond abolfazl 
Published: February 2022

Abstract
Background: After the academization of nursing, obtaining, maintaining, and promoting of clinical credibility of nursing lecturers have always been a matter of challenge. Various studies have explored strategies for maintaining and promoting clinical credibility and a review study can integrate these results. This review study was conducted to evaluate strategies for maintaining and promoting clinical credibility of nursing lecturers.Methods: This study was designed based on Noblit and Hare's qualitative meta-synthesis. Studies on clinical credibility of nursing lecturers were collected in the databases of Science Direct, PubMed, Scopus, and Eric from 2000 to 2021. Finally, after reviewing the full texts and applying the evaluation criteria, 12 articles were included in this review. Each selected article was reviewed and key concepts extracted from each study were compared with other studies for final interpretation of clinical credibility of nursing lecturers and approaches for its improvement.Results: We found that, clinical credibility of nursing lecturers has been interpreted as sufficient and appropriate experience and skills of lecturers in most of articles. Strategies for maintaining and promoting clinical credibility were organized into one main category and five subcategories, including clinical care, clinical links, transfer of skills, clinically orientated research, and motivational factors.Conclusion: According to the results of the study, it is necessary to pay attention to the dimensions of being involved in care, establishing clinical communication, transferring skills, conducting clinical research and paying attention to motivational factors to develop and maintain the clinical credibility of nursing teachers.
Grow In Adaptation: Family Caregivers' Experiences Of Caring For Neonates Undergoing Enterostomy In China—A Qualitative Study
Authors: Ni Zhi Hong , Ding Sheng , Wu Jin Hua 
Published: February 2022

Abstract
Background: More than 100,000 neonates undergo enterostomy every year in China, and the incidence continues to increase gradually. Most neonates undergoing enterostomy are cared for by family after hospital discharge. However, there is a lack of qualitative studies on family caregivers’ experiences in caring for neonates undergoing enterostomy in China.Method: An explorative design was used in which qualitative semi-structured interviews with family caregivers were conducted. Family caregivers were selected using a purposive sampling method from a children’s hospital until no new data were generated (n = 26). Reporting adhered to the consolidated criteria for reporting qualitative research checklist.Results: The experience of family caregivers was described as growing in adaptation, where five main themes emerged: (1) complex emotional responses; (2) uncertainty about everything; (3) lack of confidence, anxiety, and helplessness; (4) eagerness for professional support; (5) active adaptation, harvest, and growth.Conclusion: These findings increased understanding and added knowledge on this topic that is rarely studied in China. Healthcare authorities and professionals should recognise and understand the lives and situations of family caregivers (whose neonates undergo enterostomy) to better identify their difficulties and needs. Appropriate and effective support, both from government and society, should be planned and implemented for family caregivers caring for neonates undergoing enterostomy and maintaining the quality of their own lives.
Beyond the Purcell Effect: Modifying Spontaneous Emission via Plasmonic Doping
Authors: Ding Boyang , Chen Yu-Hui , Ijaz Mohsin , Wagner Isabella , Liu Fengjiang , Samoli Margarita , Hens Zeger , Geiregat Pieter , Hodgkiss Justin , Blaikie Richard , Chen Kai , Qiu Min 
Published: February 2022

Abstract
Optical resonators can alter quantum emitters' electromagnetic environment, thus modifying the spontaneous emission. This is known as the Purcell effect, widely regarded as the standard explanation of cavity-emitter interations. Here we show that this effect fails to properly address the emission modified by plasmonic resonators, i.e. a special type of metal cavities, where resonators can strongly affect the transition processes by charging the emitters. In particular, by integrating quantum dots (QDs) into a grating-like plasmonic resonator, we can transiently dope the QDs with a large amount of hot electrons that are produced during plasmon excitation. The doping makes the excited carriers greatly outnumber the absorbed photons, forming unusal ``asymmetric excitation" in individual QDs and yielding high-frequency radiative emission that can not be enabled by the Purcell enhancement. Our finding identifies a new cavity-emitter interaction pathway, initiating riveting opportunities for both fundamental studies and practical applications in laser, photovoltaics and photocatalysis.
The role of SMER28 in increasing the life of BMSCs after exposure to oxidative stress induced by hydrogen peroxide
Authors: mollahzadeghomi shamim , darabi shahram , mollazadehghomi shabnam 
Published: February 2022

Abstract
Background
Bone marrow mesenchymal stem cells (BMSCs) have long been of therapeutic importance in tissue engineering and restorative medicine. Recently, introducing the autophagy inducer SMER28 as a molecule for increasing BMSCs viability has received special attention. We aimed to determine the role of SMER28 in increasing the life of BMSCs after exposure to oxidative stress induced by hydrogen peroxide.
Methods
Five female and adult Wistar field samples prepared to extract BMSCs specimens. To prove the mesenchymal origin of BMSCs in the third passage, the expression of CD31, CD34, and CD106 were evaluated as the immunocytochemical markers. Trypan blue staining was performed on cells to evaluate the toxicity of H2O2 and the protective effect of SMER28.
Results
Pretreatment with SMER28 at a dose of 5 µM increased cell viability. In this regard, cell survival in medium containing SMER28 (5 µM) and H2O2 at concentrations of 50, 100, 200, 400 µM were 94%, 86%, 78%, and 43%, respectively. Compared between cells exposed to H2O2 with and without SMER28, SMER28 significantly increased cell viability and decreased cell death due to H2O2.
Conclusion
Pretreatment with SMER28 at a dose of 5 µM increases BMSCs survival.
Adjustment of p-Value Expression To Ontology Using Machine Learning For Genetic Prediction, Prioritization, Interaction, And Its Validation In Glomerular Disease
Authors: Ettetuani Boutaina , Chahboune Rajaa , Moussa Ahmed 
Published: February 2022

Abstract
Background: The selection of gene expression mixed to multiple similarity scores of their gene ontology terms (GO), were adjusted by our algorithm as essential prediction tasks for evaluating the regulatory pathways. Moreover applying machine learning techniques, in order to link the gene products into networks that prioritize candidate genes as classification. Finally detecting some significant genetic interactions by applying our algorithm model as validation of the results. Results: Experimental validation of all associations facilitates the discovery of causative genes known to be related to glomerular diseases (GD). As well as EGR1, IL33, BMP2, SLAMF8. In which their GO annotations related to this gene include kidney vasculature development, regulation of cell activation/ inflammatory/immune effector/adaptive immune/glomerulus/glomerular mesangial cell proliferation development, etc. Other genes as TNXA, FCER1A, NME3, FMOD, BTG2, PTGER4, AXL, CYP1A2, CYTL1, BHLHE40, IFI16, SPON1, ETNPPL, COL14A1, ITGAV, MYOZ2, CAMK2A, SORT1, RANBP1, in which their variants information include complement a set of C3, C4, and C7 measurement, serum IgE/IgA measurement, c-reactive protein measurement, nephrotic syndrome, immune system disease, tuberculosis, glomerular filtration rate, chronic kidney disease, etc. The lasts enable a rapid interpretation of complex gene expression studies. As well, other high-throughput genomics assays illustrate an overview of a computational model for gene prioritization and their genetic interactions. Conclusions: The furtherance of combining and adjusting the genes expression to multiple similarity scores of their gene ontology (GO) and interacting all possible cross-association of the results reported classification of genes between among to the subject category and validated the abstracts.
Hypersensitivity Reaction to Paclitaxel: A Retrospective Analysis on the Non-Inferiority of Oral Famotidine to Intravenous Ranitidine in Premedication Regimen
Authors: TSOI Tsz Ting , YOUNG Wai Man , CHEUNG Yin Ting , LAM Tai Ning , LAU Chun Yu , SUEN Shing Yu , TSUI Yuk Tung Chanel , WONG Man Ho , WONG Hong Kei , TAM Tsz Hei , ZHOU Keary Rui 
Published: February 2022

Abstract
Background: Previous studies have only evaluated intravenous histamine H2 receptor antagonists for use as paclitaxel premedication. This study aims to investigate whether oral famotidine is non-inferior to intravenous ranitidine as a premedication to prevent paclitaxel-associated hypersensitivity reactions. It could provide guidance on the use of alternative orally administered agents.Methods: It is a retrospective, multi-center, non-inferiority, historical control cohort study. Paclitaxel-naïve adult patients who began treatment with paclitaxel between August 2018 and December 2020, and received all cycles of paclitaxel in seven tertiary public hospitals in Hong Kong were enrolled. The patients received either intravenous ranitidine (control group) or oral famotidine (study group) as the premedication on the day of paclitaxel infusion. The primary outcome was the occurrence of a paclitaxel-induced hypersensitivity reaction of any severity during any cycle. The proportion of patients with the primary outcome in each group were compared by the two-proportion Z-test. The non-inferiority margin was pre-defined as an absolute hypersensitivity reaction rate difference of 5%.Results: We enrolled 1282 paclitaxel-naïve adult patients. Patients in both control (n = 635) and study (n = 647) groups had a median age of 59 years, and 476 (75%) and 485 (75%) were females, respectively. A median of five cycles of paclitaxel were administered in both groups. Hypersensitivity reactions occurred in 121 (19%) patients in study group, and 105 (17%) patients in control group (difference: +2.2%; 95% confidence interval [CI]: -2.02% to +6.35%; non-inferiority one-sided p = 0.092). A subgroup analysis of patients receiving standard-dose steroid premedication demonstrated a hypersensitivity reaction rate difference of +0.4% (95% CI: -3.97% to +4.83%, non-inferiority one-sided p = 0.021).Conclusions: We found no statistically significant differences in the hypersensitivity reaction rates between intravenous ranitidine and oral famotidine. Oral famotidine was not found to be non-inferior to intravenous ranitidine as a paclitaxel premedication based on the pre-defined non-inferiority margin. The use of oral famotidine with standard-dose steroid as premedication may provide better protection against hypersensitivity reactions.
An exploratory project to develop an effective educational system to teach mastery of assistant laparoscopic gynecologic surgery skills
Authors: Kakuda Mamoru , Kobayashi Eiji , Matsuzaki Shinya , Ueda Yutaka , Yoshino Kiyoshi , Kimura Tadashi 
Published: February 2022

Abstract
Introduction: In laparoscopic surgery, the cooperation of the first assistant surgeon is essential for the creation and maintenance of an appropriate and safe surgical field. The aim of this study is a validation of the impact of our educational system for first assistant laparoscopic surgeon residency in a single university-affiliated teaching hospital.Methods: Five residents were recruited for this study. We created a slide-set as an educational tool using Microsoft’s PowerPoint that was in line with our surgical procedure to master the assistant skills of laparoscopic gynecologic surgery. Immediately after surgery, the attending doctor and residents reviewed videos of the first assistant’s operative procedures. This study evaluated the effect of our educational check-list against the transition of evaluation scores before and after training in two groups of residents, those with minimal experience (Group 1) or with high experience (Group 2).Results: Before receiving our training tool, there was an expected significant difference in the review scores of the two experience groups (29.1±3.1 vs 48.7±3.9, p=0.01). After our modified training, the inexperienced residents of Group 1 received review scores comparable to or higher than those of the experienced residents of Group 2 (81.9±5.9 vs 70.4 ±7.5, p=0.23). As they assisted with more surgeries, the concordance between the resident’s self-assessment and the attending doctor’s assessment scores increased significantly (p<0.001). Conclusions: Our educational system for first assistant surgeons is effective for new residents, as it proved capable of imparting them with many of the same skill sets as much more experienced attending doctors.
A statistical description scheme of global sub-grid topography for numerical models
Authors: Wang Yaqi , Wang Lanning , Feng Juan , Song Zhenya , Wu Qizhong 
Published: February 2022

Abstract
Slope and aspect are the most prominent and important topographic elements for thermodynamic and dynamics of atmospheric circulation, especially for radiation and precipitation. In order to reduce the amount of computation after considering the sub-grid slope and aspect in numerical models, we propose a statistical method based on trigonometric function transformation to calculate these two factors for describing the orographic characteristics of complex areas over the world. It is found that the transformed conditional probability density function (PDF) conforms to the Gaussian distribution in most of the global areas (~98%), and this feature will not be eliminated with the improvement of resolution. Finally, the reasonability of this scheme in the Tibetan Plateau is tested by the radiation with the most significant topographic feedback. The results show that the surface solar radiation downwards (SSRD) in the Tibetan Plateau has been significantly improved compared with the results from the grid average scheme, especially in autumn. The improvement of Root mean square error (RMSE) is about 18.2 W/m2, and the improvement rate is reaching 38.4%. The improvements of maximum and regional-averaged of SSRD over the whole Tibetan Plateau are ~130W/m and ~44.3W/m2 respectively. Although we only consider the correction of solar shortwave radiation, which has a certain bias with the observation data. The improvement effect is enough to prove the rationality of the statistical method.