bluuebunny/crossref_metadata_2025_split huggingface dataset:
Off-label Use of an External Hand Fixator for Craniomaxillofacial Fractures – an Anatomical Feasibility Study
Authors: Wichlas Florian , Necchi Marco , Gruber Teresa , Hofmann Valeska , Deininger Susanne , Deininger Markus Sebastian Hubertus , Steidle-Kloc Eva , Pruszak Jan , Deininger Christian 
Published: December 2022

AbstractBackgroundThe lack of resources limits the treatment of craniomaxillofacial fractures in low-income countries (LIC). Therefore, Barton bandage and/or interdental wiring are considered being gold standard in these regions. The fracture reduction is maintained by permanent occlusion for 6 weeks, which often leads to limited compliance and dissatisfying results. Furthermore, in these conditions the healing of nasopharyngeal fistula is difficult. During humanitarian missions CMF need to be treated by trauma surgeons. The aim of this cadaver-based study is to evaluate the feasibility of the use of an external face fixator (EFF) for the treatment of CMF, its biomechanical values and to define the optimal pin insertion points and angles.Material and methodsA commercially available AO hand fixator was used. Craniomaxillofacial fractures type Le Fort 1-3 with split fracture of the hard palate were treated with EFF on 13 anatomical specimens. The fractures were created using a chisel. The pins were placed in specific anatomical regions. The maximal pull-out force [N] of the pins was analysed by a tensile force gauge. As a reference, Fmax of the mandibular pins was evaluated. Computer tomography (CT) scans were performed on the healthy, fractured and EFF-treated skulls. After reduction and EFF placement an adequate reposition was shown in the CT scans.ResultsThe pull-out forces for the single pins were as follows: mandibular pins (n=15, median 488N), supraorbital pins (n=15, median 455.0N), zygomatic pins (n=14, median 269.1N), medial hard palate pins (n=12, median 208.4N) and lateral hard palate pins (n=8, median 49.6N).ConclusionsThe results of the presented study on the cadaver show, that the operation technique is feasible, and the stability of the EFF is sufficient for maintaining the reduction. In addition, the required pins can be safely inserted into the described areas and a good reduction result can be achieved. The technique of the EFF offers a feasible alternative to the non-surgical treatment of CMF in LIC. Thus, the gap between the open reduction and internal fixation techniques (mini-plates) used in High-income countries and the Barton bandage used in LIC can be closed.Trial registration:A vote of the local ethics committee was obtained (13.01.2022, Ethikkommission Land Salzburg, Austria). EK Nr: 1198/2021 Level of evidence: Level 2
Holographic entanglement entropy with Power-MaxWell electrodynamics in higher dimensional AdS black hole spacetime
Authors: Wang Kongchen , Zhang Wanhe , Yao Weiping 
Published: December 2022

Abstract
We investigate the behaviors of scalar operator and holographic entanglement entropy in metal/superconductor phase transition with Power-MaxWell electrodynamics in higher dimensional background away from the probe limit. We observe that the larger Power-MaxWell parameter b makes the phase transition more difficult and the critical temperature decreases more slowly as the factor b increases. In the belt geometry, we find that the holographic entanglement entropy is a powerful tool to probe the critical temperature and the order of the phase transition. At the phase transition point, the entanglement entropy increases with the increase of the factor b and the belt width of the geometry $\ell$. Interestingly, the width $\ell$ has no effect on critical temperature of the phase transition.
PACS numbers: 11.25.Tq, 04.70.Bw, 74.20.-z, 97.60.Lf.
Reactivation of memory-encoding dentate gyrus neurons during memory consolidation is associated with subregion-specific, learning- and sleep-mediated biosynthetic changes
Authors: Wang Lijing , Park Lauren , Wu Weisheng , King Dana , Medina Alexis Vega , Raven Frank , Martinez Jessy , Ensing Amy , Yang Zhongying , Jiang Sha , Aton Sara 
Published: December 2022

Abstract

Post-learning sleep plays an important role in hippocampal memory processing, including contextual fear memory (CFM) consolidation. Here, we used targeted recombination in activated populations (TRAP) to label context-encoding engram neurons in the hippocampal dentate gyrus (DG) and assessed reactivation of these neurons during post-learning sleep. We find that post-learning sleep deprivation (SD), which impairs CFM consolidation, selectively disrupts reactivation in inferior blade DG engram neurons. This change was linked to more general suppression of neuronal activity markers in the inferior, but not superior, DG blade by SD. To further characterize how learning and subsequent sleep or SD affect these (and other) hippocampal subregions, we used subregion-specific spatial profiling of transcripts and proteins. We found that transcriptomic responses to sleep loss differed greatly between hippocampal regions CA1, CA3, and DG inferior blade, superior blade, and hilus. Critically, learning-driven transcriptomic changes, measured 6 h following contextual fear learning, were limited to the two DG blades, differed dramatically between the blades, and were absent from all other regions. Similarly, protein abundance in these hippocampal subregions were differentially impacted by sleep vs. SD and by prior learning, with the majority of alterations to protein expression restricted to DG. Together, these data suggest that the DG plays an essential role in the consolidation of hippocampal memories, and that the effects of sleep and sleep loss on the hippocampus are highly subregion-specific, even within the DG itself.
Morphological and organic spectroscopic studies of a 44-million-year-old leaf beetle (Coleoptera: Chrysomelidae) with preserved α-chitin
Authors: Mitchell Jerit L. , McKellar Ryan C. , Barbi Mauricio , Coulson Ian M. , Bukejs Andris 
Published: December 2022

Abstract
This study details the quality of organic preservation of amber deposits in the Eocene. Through Baltic amber crack-out studies using Synchrotron Micro-Computed Tomography and Scanning Electron Microscopy it was found that the cuticle of a specimen of leaf beetle (Crepidodera tertiotertiaria) (Alticini: Galerucinae: Chrysomelidae)) is exceptionally well preserved. Spectroscopic analysis using Synchrotron Fourier Transform Infrared Spectroscopy shows presence of original organic α-chitin, and Energy Dispersive Spectroscopy supports the presence of organic preservation. This sets a new upper temporal limit for the preservation of original chitin found in insects (25 to 44 Ma). This unprecedented preservation is interpreted as the result of the favourable antimicrobial and physical shielding properties of Baltic amber as compared to other depositional media, coupled to rapid dehydration of the beetle early in its taphonomic process. We suggest that pessimism associated with ancient original organic preservation can be challenged as long as the pitfalls of organic spectroscopy are properly managed and appropriate targets are chosen for analysis.
Socio-ecological resilience of marginal coral reefs in Java Sea Indonesia
Authors: Suryono Suryono , Ambariyanto Ambariyanto , Munasik Munasik , Wijayanti Diah Permata 
Published: December 2022

Abstract

The marginal coral reefs in the Java Sea, Indonesia, have been degraded due to two main factors: disturbances from nature and human activities (anthropogenic). The accumulated increased pressure it receives has resulted in more severe degradation impacts on coral reef ecosystems. Therefore, it is essential to know the socio-ecological resilience of the coral reef ecosystem. The research aims to study the socio-ecological resilience of marginal coral reefs in the Java Sea. The research method used was the survey method. The socio-ecological resilience index was assessed from the attributes of bioecology of coral reefs resilience, reef fish resilience, Socio-cultural resilience, and Socioeconomic resilience. The results showed that the bioecology Coral reef resilience index was in the medium category (2 .72). The resilience index of reef fish was in the inferior class (1). The socio-cultural resilience index is good (3,62), socioeconomic resilience index has a good resilience value (3.14). The socio-ecological resilience index of the coral reef ecosystem is 2.45, which means the poor category.
Desiderata for the governance of health data hubs for research
Authors: Alvarez-Romero Celia , Martínez-García Alicia , Bernabeu-Wittel Máximo , Parra-Calderón Carlos Luis 
Published: December 2022

Abstract
Background
Digital transformation in healthcare and the growth of health data generation and collection include an important challenge for the secondary use of healthcare records in the health research field. Likewise, due to the ethical and legal constraints for using sensitive data, understanding how health data is managed by dedicated infrastructures called data hubs is essential to facilitate data sharing and reuse.
Methods
In order to capture the different data governance behind health data hubs across Europe, a survey focused on analysing the feasibility of linking individual-level data between data collections and the generation of health data governance patterns was carried out. The target audience of this study was National, European, and Worldwide data hubs. In total, the designed survey was sent to a representative list of 99 health data hubs in January 2022.
Results
In total, 41 survey responses received till June 2022 were analysed in-depth. Stratification methods were performed to cover the different levels of granularity identified in some data hubs’ characteristics. Firstly, a general pattern of data governance for data hubs was defined. Afterward, specific profiles were defined, generating specific patterns of data governance through the stratifications in terms of the kind of organisation (centralised vs. decentralised), and role (data controller or data processor) of the health data hubs interviewees.
Conclusions
The in-depth analysis of the responses from health data hubs interviewees across Europe provided a list of the most frequent aspects that concluded a set of specific recommendations on data management and governance, taking into account the constraints of sensitive data. In summary, a data hub should work in a centralised way providing a Data Processing Agreement and a formal procedure to identify data providers, as well as data quality control, data integrity and anonymisation methods.
Serum Lactate Dehydrogenase Level Predicts the Prognosis in Bladder Cancer Patients
Authors: Gu Shuo , Yang Chao 
Published: December 2022

Abstract
Background
Recently, several studies investigated the association between lactate dehydrogenase (LDH) level and the prognosis of urothelial carcinoma. However, no studies explored the role of serum LDH level in the survival of overall bladder cancer (BC). In this study, we intended to address the association of LDH level with the prognosis of BC.
Methods
206 patients with BC were included in this study. The clinical data and blood samples of patients were collected. The overall survival (OS) and progression-free survival (PFS) were used. Kaplan-Meier method and Log rank test were used to evaluate the effects of LDH level on the survival of BC. Univariate and multivariate Cox regression analyses were utilized to identify prognosis predictors of BC.
Results
Data indicated that serum LDH level in the BC patients was significantly higher than those in controls. In addition, this study suggested that serum LDH level was associated with T stage, N stage, tumor size, M stage, pathological type, treatment methods, and lymphovascular invasion. The Kaplan-Meier analysis found significant differences in the OS and PFS rate between lower and higher serum LDH level groups (LDH ≥ 225 U/L and < 225 U/L). Multivariate Cox regression indicated that pathological type, treatment methods, and higher level of LDH were independently associated with adverse prognosis in BC patients.
Conclusion
The higher serum LDH level (≥ 225 U/L) is associated with poor prognosis in patients with BC. Serum LDH level could be used as a novel predictive biomarker for BC patients.
Path analysis of the role of frailty, psychological state, and sleep quality on quality of life in patients receiving maintenance haemodialysis
Authors: Wang Jing , Tao MingFen , Ding YuDie , Zhuang Ying , Ma ShaoYong , Yao YingShui , Chen Yan 
Published: December 2022

Abstract
Background

End-stage renal disease (ESRD) incidence has increased recently. Maintenance hemodialysis (MHD), which removes squandering and extra fluid from the blood while maintaining electrolyte balance, is a commonly used treatment for people with ESRD. MHD decreases the likelihood of ESRD complications while enhancing the quality of life. Therefore, MHD is an important treatment option for patients with ESRD.

Objectives

The study aimed to investigate the correlation between the influencing factors and quality of life in patients receiving MHD and to provide a theoretical basis for clinical medical workers to carry out targeted treatment and nursing of patients receiving MHD.

Material and Methods

Participants were recruited from the Blood Purification Center of a tertiary hospital in Wuhu City, a total of 147 samples received MHD treatment since 2015. Standardized interviews were conducted with 147 patients. The EQ-5D-5L, Kessler10, SRSS, and FRAIL scales, measure various aspects of life quality, mental health, sleep quality, and debilitating status, respectively. And structural equation model of influencing factors related to the quality of life was constructed.

Results

The UI (Mean = 0.82) for 147 participants was lower than normal (Mean = 0.98). There were significant differences in UI effect values in patients receiving MHD of different ages, education levels, exercise habits, sleep duration, primary disease, and comorbidity (all P < 0.05), and CVAS effect values between patients receiving MHD with different family locations, primary diseases, comorbidity and erythromycin-stimulating frequency (all P < 0.05). There was a positive correlation between the degree of frailty and the quality of life of patients receiving MHD (P = 0.034). There was a negative correlation between mental state and quality of life (P < 0.001) and a negative correlation between sleep quality and mental state (P < 0.001). Psychological status played a mediating role between sleep quality and quality of life in patients with MHD (Effect value is 0.005, P = 0.001 < 0.05).

Conclusion

Patients on maintenance hemodialysis have a poor quality of life. The quality of life is influenced by a variety of factors. To lessen the burden of symptoms and enhance patients' quality of life, customized nursing interventions should be developed following the individual conditions of each patient.
Perceptions surrounding the possible interaction between physical activity, pollution and asthma in children and adolescents with and without asthma
Authors: Jordan Kathryn A , Mackintosh Kelly A , Davies Gwyneth A , Griffiths Chris J , Lewis Paul D , McNarry Melitta 
Published: December 2022

Abstract
The interrelationship between air pollution and childhood asthma is debated. Specifically, the management of asthma is partially dependent on maintaining physical activity (PA), but this may lead to increased exposure to, and deeper inhalation of, pollutants. Despite the recent air quality campaigns and media coverage surrounding the dangers of air pollution to respiratory health, few target children and their understanding of such issues. Using semi structured interviews, understanding of PA, air pollution and their interaction was explored with 25 youth aged 7–17 years. Utilising NVIVO 12 software, an atheoretical, inductive thematic analysis was conducted to identify key themes which were subsequently presented as pen with the number of common responses within a theme indicative of its strength. The majority (88%) of youth’s indicated traffic-related air pollution and global manufacturing as key sources of air pollution. Whilst all youths were aware of outdoor pollution, only 52% were aware of indoor air pollutants, of which 62% had asthma. Despite some uncertainty, all youths described pollution in a negative fashion, with 52% linking air pollution to undesirable effects on health, specifically respiratory health. PA in a polluted area was thought to be more dangerous than beneficial by 44%, although 24% suggested the benefits of PA would outweigh any detriment from pollution. Youth are aware of, and potentially compensate for, the interaction between air pollution and PA. Strategies are needed to allow youth to make more informed decisions regarding how to promote PA whilst minimising exposure to air pollution.
Status of Ornamental Fish Cyphotilapia Frontosa Trade From Lake Tanganyika, Tanzania
Authors: Peter Florence J. , Kitula Rukia A. 
Published: December 2022

Abstract
This study focused on assessing the status of ornamental fish Cyphotilapia frontosa trade from Lake Tanganyika, Tanzania to provide a good ground for interested parties to undertake well-designed interventions to protect wild stock from depletion. Purposive sampling was used to select fishers and traders of ornamental fish from Katonga, Mwamugongo and Ilagala villages in Kigoma for interview. Key informant interviews, focus group discussions and questionnaires were used for primary data collection. The results showed that much attention is paid during handling and packaging of ornamental fish from collection point to destination to maximize their survival rate. However, there were declining trends of ornamental fish exportation from 15,398 to 12,722 between 2013 and 2019. Ornamental fish C. frontosa are sold in pairs and the most common sex ratio traded was 1 male:3 females. The most price used in trading C. frontosa ranged from USD16 to USD20. Ornamental fish C. frontosa was a good source of income for local communities and the nation at large. It could generate about TZS 159,516,000/= per year per company from exporting C. frontosa. China was the leading foreign market for ornamental fish C. frontosa from Tanzania. Legal frameworks are important components in the fishery and trade of ornamental fish. There should be ornamental fish breeding of C. frontosa in the country to avoid much dependence on fishing from the Lake hence it will ensure the sustainability of the fishery of ornamental fishes and their trade from one generation to another.
Social Vulnerability to Environmental Disasters in the Paraopeba River Watershed, Minas Gerais, Brazil
Authors: Roque Mariane Paulina batalha , Neto José Ambrósio Ferreira , Vieira Wilson da Cruz , Rocha Bianca Diniz da , Calegario Arthur Telles 
Published: December 2022

Abstract
The increase in the number of environmental disasters, in recent years, has led to a reorientation of research and programs. This study proposes a set of 16 theoretically significant variables to measure and map vulnerability in Brazil, after about a major socioenvironmental disaster in Brazil, also considered one of the biggest in the world. They were grouped into three indicators, social, economic, and infrastructure aspects of the population, obtained from the Brazilian census database. The Córrego do Feijão tailings dam, in Brumadinho, and the Casa de Pedra tailings dam, in Congonhas were taken as case studies. The vulnerability of 48 municipalities and 3,732 census sectors from the Paraopeba River Watershed were explored from two different perspectives: where the disaster has already happened and where it could happen. The index and indicators used were developed in the open-source software and the maps in a geographic information system (SIG). The results show considerable variability. The most vulnerable municipalities are in the lower part of the watershed while the High Paraopeba region is less vulnerable. This paper presents methodological and empirical contributions of the social dimensions of vulnerability the preparation, response, and recovery of affected communities to environmental disasters.
Expanding the application of haplotype-based genomic predictions to the wild: A case of antibody response against Teladorsagia circumcincta in Soay sheep
Authors: Vahedi Seyed Milad , Ardetani Siavash Salek , Brito Luiz Fernando , Karimi Karim , Afshar Kian Pahlavan , Banabazi Mohammad Hossein 
Published: December 2022

Abstract
Background
Genomic prediction of breeding values (GP) has been adopted in evolutionary genomic studies to uncover microevolutionary processes of wild populations or improve captive breeding strategies. While recent evolutionary studies applied GP with individual single nucleotide polymorphism (SNP), haplotype-based GP could outperform individual SNP predictions through more capture of the linkage disequilibrium (LD) between the SNP and quantitative trait loci (QTL). This study aimed to compare the accuracy and bias of Genomic Best Linear Unbiased Prediction (GBLUP) and five Bayesian methods [BayesA, BayesB, BayesCπ, Bayesian Lasso (BayesL), and BayesR] for GP of immunoglobulin (Ig) A (IgA), IgE, and IgG against Teladorsagia circumcincta in lambs of an unmanaged sheep population (Soay breed). Genomic predictions using SNP, haplotypic pseudo-SNP from blocks with different LD thresholds (0.15, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 and 1.00), or the combinations of pseudo-SNPs and non-LD clustered SNPs were evaluated.
Results
Higher ranges of accuracies were observed for IgA (0.36 to 0.82), followed by IgE (0.20 to 0.60), and IgG (0.09 to 0.33). For IgA, up to 33% gain in GP accuracy was obtained using the combinations of the pseudo-SNPs with non-clustered SNPs compared to GBLUP using SNPs. For IgE and IgG, up to 17% and 22% gains in accuracy were achieved by haplotype-based GPs compared to GBLUP using SNPs, respectively. Among haplotype-based GPs of IgA, lower accuracies were obtained with higher LD thresholds, whereas a reverse trend was observed for IgE and IgG. Bayesian methods outperformed GBLUP; BayesB achieved the most accurate Genomic Estimated Breeding Values (GEBV) for IgA (0.82) and IgG (0.33) and BayesCπ for IgE (0.60). Haplotype-based GPs predicted less-biased GEBVs in most IgG scenarios with high LD thresholds compared with SNP-based GBLUP, whereas no improvement in bias was observed for other traits.
Conclusions
Haplotype-based methods improved GP accuracy of anti-helminthic antibody traits compared to GBLUP using individual SNP. The observed gains in the predictive performances indicate that haplotype-based methods could be advantageous for some traits in unmanaged wild animal populations.
Health-related quality of life in migraine and non-migraine elderly using EQ-5D visual analog scale and utility index values
Authors: Fayegh Asieh Kouhi , Sulaiman Wan Aliaa Wan , Basri Hamidon , Ravanipour Maryam , Mohamed Mohd Hazmi , Din Hazwan Mat , Mat Liyana Najwa Inche 
Published: December 2022

AbstractBackground:The EQ-5D was used to compare the quality of life between the elderly with migraine and without migraine.Methods:A comparative cross-sectional survey of elderly participants was conducted in neurology clinics located in Tehran, Iran for a period of 2 years. The sample size was calculated as 186, including 63 migraine and 126 non-migraine groups. Mean EQ-5D scores were compared across groups using paired t-tests. We also compare the sociodemographic profiles of the 2 groups.Results:Apart from age, gender and occupation status there is no significant difference in marital status and education level between migraine and non-migraine groups. Mean EQ-5D scores were lower in elderly migraineurs. Moreover, there was a significant difference in all components of quality of life including mobility, self-care, usual activities, pain/discomfort and anxiety/depression as well as health utility index between the two groups of elderly with and without migraine.Conclusion:Migraine patients had lower EQ-5D scores compared to the non-migraine group, however, the elderly reported lower quality of life in general.