bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classifying Characteristics of Opioid Use Disorder From Hospital Discharge Summaries Using Natural Language Processing
Authors: Poulsen Melissa N. , Freda Philip J. , Troiani Vanessa , Davoudi Anahita , Mowery Danielle L. 
Published: May 2022

BackgroundOpioid use disorder (OUD) is underdiagnosed in health system settings, limiting research on OUD using electronic health records (EHRs). Medical encounter notes can enrich structured EHR data with documented signs and symptoms of OUD and social risks and behaviors. To capture this information at scale, natural language processing (NLP) tools must be developed and evaluated. We developed and applied an annotation schema to deeply characterize OUD and related clinical, behavioral, and environmental factors, and automated the annotation schema using machine learning and deep learning-based approaches.MethodsUsing the MIMIC-III Critical Care Database, we queried hospital discharge summaries of patients with International Classification of Diseases (ICD-9) OUD diagnostic codes. We developed an annotation schema to characterize problematic opioid use, identify individuals with potential OUD, and provide psychosocial context. Two annotators reviewed discharge summaries from 100 patients. We randomly sampled patients with their associated annotated sentences and divided them into training (66 patients; 2,127 annotated sentences) and testing (29 patients; 1,149 annotated sentences) sets. We used the training set to generate features, employing three NLP algorithms/knowledge sources. We trained and tested prediction models for classification with a traditional machine learner (logistic regression) and deep learning approach (Autogluon based on ELECTRA's replaced token detection model). We applied a five-fold cross-validation approach to reduce bias in performance estimates.ResultsThe resulting annotation schema contained 32 classes. We achieved moderate inter-annotator agreement, with F1-scores across all classes increasing from 48 to 66%. Five classes had a sufficient number of annotations for automation; of these, we observed consistently high performance (F1-scores) across training and testing sets for drug screening (training: 91–96; testing: 91–94) and opioid type (training: 86–96; testing: 86–99). Performance dropped from training and to testing sets for other drug use (training: 52–65; testing: 40–48), pain management (training: 72–78; testing: 61–78) and psychiatric (training: 73–80; testing: 72). Autogluon achieved the highest performance.ConclusionThis pilot study demonstrated that rich information regarding problematic opioid use can be manually identified by annotators. However, more training samples and features would improve our ability to reliably identify less common classes from clinical text, including text from outpatient settings.
A Case Report and Review of the Literature of Penile Metastasis From Rectal Cancer
Authors: Kaminskas Azuolas , Patasius Ausvydas , Kincius Marius , Sapoka Virginijus , Zilevicius Rytis , Garnelytė Aušra , Dulskas Audrius 
Published: May 2022

BackgroundMetastatic involvement of the penis in cases of rectal cancer is exceptionally rare condition. Our clinical case report and review of the literature will contribute in complementing currently limited data on penile metastasis from rectal cancer.Case reportWe report a case of a 64-year-old male diagnosed with penile metastasis from rectal cancer. The patient was treated with neoadjuvant chemoradiotherapy followed by total mesorectal excision (TME). However, penile metastasis developed 3 years later, clinically presenting as penile pain and solid formations along the entire length of the penis with visible tumor in the head of the penis. The amputation of penis was performed, and adjuvant chemotherapy was prescribed. The patient survived only 6 months.ConclusionPenile metastasis from rectal cancer in most cases is a lethal pathology that indicates wide dissemination of oncological disease and has a very poor prognosis. Aggressive surgical treatment is doubtful in metastatic disease as this will negatively affect the quality of life.
Whether Out-of-Bed Activity Restriction in the Early Postoperative Period of PELD Is Beneficial to Therapeutic Efficacy or Reduce Recurrence
Authors: Liang Xiao , Wang Yexin , Yue Yaosheng , Li Yanpeng , Meng Chunyang 
Published: May 2022

ObjectiveTo detect the influences of postoperative out-of-bed activity restriction on recurrence rate, low back and leg pain, functional rehabilitation after percutaneous endoscopic lumbar discectomy (PELD).MethodsIn this research, 213 patients with lumbar intervertebral disc herniation (LDH) who underwent PELD were divided into the out-of-bed activity restriction group and out-of-bed activity non-restriction group. The visual analog scale (VAS) and Oswestry disability index (ODI) scores were used to evaluate postoperative clinical efficacy at 1 and 3 months after the operation, and to count the recurrence rates. All of these operations were performed between August 2017 and July 2020, and they were followed in the outpatient department for 12 months at least.ResultsBoth of the groups showed significantly lower VAS and higher ODI scores at 1 month and 3 months post-operation, respectively, when compared with pre-operation. At 1 month after the operation, the restriction group performed lower VAS scores of low back pain compared with the non-restriction group, but this advantage disappeared at 3months post-operation. However, there was no statistical difference in the VAS scores of leg pain and ODI scores between the two groups, neither at 1 nor 3 months after the surgery. The recurrence rate is significantly lower in the restriction group than in the non-restriction group at a 12-month follow-up after the surgery.ConclusionOut-of-bed activity restriction in the early postoperative period of PELD could reduce LDH recurrence effectively, and it may relieve the low back pain to some extent. It has no benefit in the recovery of leg pain and functional rehabilitation.
Top 50 Most Cited Articles on Thoracic Ossification of Posterior Longitudinal Ligament
Authors: Ding Xing , Yan Ming , Wu Jinze , Xu Chongqing , Yan Yinjie , Yu Zhixing , Yin Mengchen , Xu Jinhai , Ma Junming , Mo Wen 
Published: May 2022

Study DesignBibliometric analysis.ObjectiveOver the last several decades, the field of thoracic ossification of the posterior longitudinal ligament (T-OPLL) has evolved unprecedentedly, and the literature on T-OPLL has increased significantly. The purpose of this study is to identify and review the top 50 most cited publications related to T-OPLL.MethodsThe most frequently cited 50 articles in this field until 30 October 2021 were identified by searching Web of Science. We ranked the articles based on the citation number. Through the bibliometric method, we evaluated the following information: article title, first author, year of publication, journal of publication, total number of citations, country, and study topic.ResultsThe number of citations of included studies ranged from 20 to 108, with a mean number of 45.4. The journal Spine published most articles (20), followed by Spinal Cord (5), and European Spine (5). All of these articles were contributed by 38 first authors, Yamazaki (4), Fujimura (3), and Aizawa (3) who published more than 2 articles. In the respect of productive countries, Japan (39) contributed most papers. Tomita contributed the most cited article in 1990 on Spine, which was the first-ever report of circumferential decompression for thoracic myelopathy due to T-OPLL.ConclusionThe top 50 influential articles on T-OPLL were identified and analyzed in this study. It will undoubtedly provide a comprehensive and detailed basis for the orthopedic and neurosurgery physicians to make a clinical decision and assimilate the research focus of spine surgery.
Sentinel Node Biopsy for Endometrial Cancer by Retroperitoneal Transvaginal Natural Orifice Transluminal Endoscopic Surgery: A Preliminary Study
Authors: Huber Daniela , Hurni Yannick 
Published: May 2022

ObjectiveThe primary objective was to determine the intraoperative and postoperative surgical complications of sentinel lymph node biopsy (SLNB) by retroperitoneal transvaginal natural orifice transluminal endoscopic surgery (vNOTES). The secondary objective was to assess the feasibility of this surgical technique.MethodsThis was a descriptive study realized in a non-university hospital in Switzerland. Seven patients with endometrial cancer or endometrial complex atypical hyperplasia underwent surgical staging with SLNB by retroperitoneal vNOTES using an indocyanine green-based near-infrared fluorescence imaging technique (October 2021–February 2022).ResultsThe median operative time was 113 (81–211) minutes. The median estimated blood loss was 20 (20–400) mL. The overall bilateral detection rate was 100% (7/7). Upon histopathological examination, 5 patients presented an endometrial adenocarcinoma, and we found endometrial complex atypical hyperplasia in 2 cases. We successfully completed all procedures without significant intraoperative complications, but 1 case required conversion to conventional laparoscopy. The median postoperative stay was 2 (2–4) days, and we observed no postoperative complications during this period. We observed 1 case of postoperative deep vein thrombosis and an asymptomatic vaginal vault hematoma in the same patient.ConclusionsOur preliminary study suggests that retroperitoneal vNOTES could be a feasible, safe, and valuable approach to perform SLNB in endometrial cancer. However, strong evidence of its feasibility, the effective benefits, and the long-term oncological outcomes is needed before expanding the use of vNOTES in endometrial cancer outside study settings.
Plasma and Whole Blood Taurine Concentrations in Dogs May Not Be Sensitive Indicators of Taurine Deficiency When Dietary Sulfur Amino Acid Content Is Reduced
Authors: Tôrres Cristina L. , Biourge Vincent C. , Backus Robert C. 
Published: May 2022

BackgroundTaurine status is impacted by dietary supply of methionine and cysteine (SAA) and possibly intestinal microbial activity, where plasma and whole blood taurine concentrations are currently used to evaluate taurine status.ObjectiveWe determined effects of dietary SAA restriction on rate and extent of taurine depletion of blood and skeletal muscle in dogs of two body sizes, and whether oral antibiotic administration affected the taurine depletion and fecal bile acid excretion of the dogs.MethodsAdult, male, Beagles (n= 6; 10.1–13.1 kg) and larger mixed-breed dogs (n= 6; 28.5–41.1 kg) were given four dry-expanded diets, whereby each successive diet contained lower protein and/or SAA concentration. After receiving the final diet for 44 weeks, all dogs were orally administered a mixture of ampicillin, neomycin sulfate, and metronidazole for 12 weeks. Taurine concentrations were determined every 2–4 weeks in venous blood and voided urine and every 4 to 16 weeks in biopsied semimembranosus muscle. Fecal bile acid excretion before and after antibiotics administration were quantified.ResultsWhen given for 36 weeks the lowest SAA diet, 3.4% methionine and 2.9% cystine, taurine concentrations in whole blood were not different between groups, while taurine in plasma declined (P&lt; 0.05) in large but not in small dogs, and taurine in biopsied muscle decreased (P&lt; 0.05) by 50% in large and by 37% in small dogs. Concentrations of taurine in muscle were lower (P&lt; 0.01) and fecal bile acids greater (P= 0.001) in large than small dogs. Antibiotic administration restored plasma and muscle taurine to initial concentrations and halved fecal bile acid excretion by dogs of both groups.ConclusionsBlood taurine concentration may not be a sensitive indictor of taurine depletion caused by low intake of bioavailable SAA in dogs, especially in large dogs. Taurine status and dietary SAA requirements of dogs may substantively depend on taurine loss mediated by intestinal microbiota.
The Effect Of Black Sticky Rice Tape Consumption On Alteration Of Saliva Ph On Tsanawiyyah Student Of Islamic Boarding School No.3 Pameungpeuk Sub-District Bandung
Authors: Laut Deru Marah 
Published: May 2022

Background : Saliva in the oral cavity serves not only to help in mastication, but also has a protective function, which is maintaining oral hygiene through cleaning mechanisms and coating any tissue in the oral cavity. Many people now consume fermented foods for dessert dishes such a black sticky rice tape. People know that black sticky rice tape has health benefits, such as for body metabolism and antioxidants.
Methods : This research aims to determine the effect of black sticky rice tape consumption on saliva pH on students of Islamic Boarding School No.3 Pameungpeuk, Bandung. The techniques of the research are analytic with quasi experiment design and random sampling tehnique with 45 respondents. The sample is to eat black sticky rice tape as much as 1 tablespoon then do saliva pH examination at 10 minutes after. The saliva pH is measured by digital pH meter analyzed by using T-test dependent.
Results : The results of this research indicate that the effect of black sticky rice tape on saliva pH at the time of examination 10 minutes with <0,05 and after tested with the normalization test found p value >0,05.
Conclusion : It can be concluded that is a significant effect of the black sticky rice tape on saliva pH on students of Islamic Boarding School No.3 Pameungpeuk, Bandung.
EFFECT OF PHYSICAL ACTIVITIES AND NUTRITIONAL STATUS OF DISMENORE EVENTS IN ADOLESCENT
Authors: Mulyati Sri , Sasnitiari Ni Nyoman 
Published: May 2022

As many as 67.8% of adolescents are disrupted due to primary dysmenorrhoea. Dysmenorrhea can affect adolescent academic performance. Routine and regular sports activities twice or more per week have a smaller tendency to suffer from dysmenorrhea.
The purpose of this study was to analyze the relationship between physical activity patterns and dysmenorrhea. The results of the study are expected to be used as a reference for health workers in implementing prevention programs and addressing the problem patterns of activities in adolescents to overcome dysmenorrhea complaints.
The study was conducted using a case control-retrospective approach. Held in July-October 2018 at SMPN 4 which was effective in carrying out extracurricular activities. Respondents in this study were eighth-grade students of Junior High School who had experienced menarche at least 6 months before doing research. The sample size was calculated using the Hypothesis test formula of two population proportions, as many 65 people for each control group and case. The sampling technique used simple random sampling. The independent variable was the pattern of physical activity, while the dependent variable was the incidence of dysmenorrhoea. Univariate and bivariable research analysis using the chi-square test.
The results showed a significant effect between activity patterns (p = 0.031) and nutritional status (p = 0.015) on dysmenorrhoeal events. Adolescent girls who are not physically active have a 2,585 chance of experiencing dysmenorrhoea. Adolescent girls with poor nutritional status have a 2.76 times chance of experiencing dysmenorrhoea
Suggestions teens should do regular physical activity and also maintain nutritional intake by consuming balanced nutritional food as a preventive measure for dysmenorrhea.
DAMPAK PENCEMARAN SUNGAI DI INDONESIA TERHADAP GANGGUAN KESEHATAN : LITERATURE REVIEW
Authors: Sugiester S Farida , Firmansyah Yura Witsqa , Widiyantoro Wahyu , Fuadi Mirza Fathan , Afrina Yana , Hardiyanto Afdal 
Published: May 2022

Pencemaran sungai di indonesia sangat tinggi. sepanjang tahun 2016, berdasarkan data dari Kementerian Lingkungan Hidup Dan Kehutanan (LHK), dari 140 sungai di 34 provinsi, sebanyak 73,24% dalam status tercemar. Terdapat 2,01% sungai yang memenuhi baku mutu air kelas 2. Menggunakan pendekatan literatur review ini untuk mengetahui hubungan pencemaran sungai dengan gangguan kesehatan berdasarkan hasil penelitian terdahulu yang di rangkum dalam penelitian berbasis kesehatan lingkungan Penelitian ini merupakan literatur review. Penurunan akibat kualitas air akan menurunkan dayaguna, hasil guna, produktivitas, serta daya dukung dan daya tampung dari sumber daya air yang pada akhirnya akan memperburuk kekayaan sumber daya alam (natural resources depletion). sumber air dibagikan menjadi 4 kelompok yaitu air permukaan, air tanah, air hujan dan mata air.Pada beberapa penelitian yang telaah dianalisis sumber air yang digunakan adalah air sungai dan air sumur. Berdasarkan analisis yang telah di telaah dari penelitian diatas dapat disimpulkan Masyarakat menggunakan sungai , sumur dalam aktivitas sehari-hari .hal ini terlihat jelas dari beberapa penelitian yang menganalisa kualitas air dari parameter kimia, fisika, serta biologi yang melebihi baku mutu . Dari pencemaran tersebut didapatkan masalah kesehatan seperti penyakit gangguan kulit, dermatitis, hingga diare.
PERBEDAAN HASIL KONTROL PLAK SEBELUM DAN SESUDAH MELIHAT VIDEO TUTORIAL MODIFIED BASS TECHNIQUE KELAS V
Authors: Laut Deru Marah , Alfiaty Noor , Nurnaningsih Hera , Herijulianti Eliza 
Published: May 2022

Riset Kesehatan Dasar (RISKESDAS, 2018) mencatat proporsi masalah gigi dan mulut sebesar 57,6% Adapun proporsi perilaku menyikat gigi dengan benar sebesar 2,8%. Berdasarkan data tersebut diperlukan solusi untuk meningkatkan perilaku masyarakat untuk menyikat gigi dengan benar sehingga dapat menurunkan proposi masalah gigi dan mulut secara signifikan. Penelitian ini bertujuan untuk mengetahui perbedaan hasil kontrol plak sebelum dan sesudah melihat video tutorial menyikat gigi modified bass technique pada siswa kelas V SDN X Kabupaten Subang. Metode penelitian yaitu analitik. Teknik pengambilan sampel menggunakan teknik purposive sampling (30 Responden). Pengumpulan data pada penelitian ini dilakukan pengamatan langsung terhadap siswa kelas V SDN X, dengan mempraktekan cara menyikat gigi setelah melihat video tutorial menyikat gigi modified bass technique dan pemeriksaan langsung terhadap status kesehatan gigi dan mulutnya (Plaque Control). Hasil uji statistik menggunakan t-paired test dengan hipotesis dua arah di peroleh rata-rata hasil menyikat gigi pada kunjungan ke-1 sebelum melihat video tutorial sebesar 21% dan sesudah melihat video tutorial menjadi 13%. Pada plak kontrol yang ke-2 didapatkan rata-rata skor 3% dan pada plak kontrol yang ke-3 didapatkan rata-rata skor yaitu 1%. Sehingga adanya penurunan hasil plak kontrol. Dengan melihat t hitung > t tabel maka keputusannya Ho ditolak dan “Ha diterima” artinya ada perbedaan signifikan antara hasil kontrol plak sebelum dan setelah melihat video tutorial menyikat gigi modified bass technique pada siswa kelas V SDN X Kabupaten Subang.
EFEKTIVITAS SARI BUAH MULBERRY (Morus alba L) PADA PLAK GIGI SEBAGAI BAHAN ALTERNATIF PENGGANTI DISCLOSING SOLUTION
Authors: Laela Dewi Sodja , Mulyanti Sri , Nurnaningsih Hera 
Published: May 2022

Plak berperan penting dalam proses terjadinya karies dan penyakit jaringan periodontal (Forest, 2005). Plak yang tipis memiliki warna hampir sama dengan warna gigi. Plak tidak dapat terlihat dengan kasat mata kecuali bila diwarnai dengan zat pewarna.Dunia kedokteran gigi mengembangkan suatu teknik pewarnaan sel bakteri plak dengan menggunakan cairan disclosing solution. (Forest). Disclosing solution dipasaran tersedia dalam bentuk cairan, tablet atau bentuk bubuk terbuat dari bahan-bahan kimia. Bahan tradisional dapat dijadikan alternatif pengganti disclosing solution. Buah tradisional yang mengandung cairan berwarna merah. salah satunya adalah mulbery. Winarno (2002) menyatakan konsentrasi antosianin dari buah mulberry mengalami peningkatan sampai pada hari ke 15 menjadi 544,8 mg/L.
Penelitian ini bermaksud mensosialisasikan penggunaan sari buah mulberry pada plak gigi sebagai bahan alternatif pengganti disklosing solution. Metode penelitian menggunakan quasi eksperimen dengan rancangan. Pre and post with Control Group Design. Uji hipotesis menggunakan Wilcoxon Signed Ranks Test. Pada penelitian ini uji Wilcoxon Signed Ranks Test menunjukkan nilai p (0,813) >0,05 artinya jumlah plak pada permukaan gigi yang terwarnai antara yang menggunakan sari buah Mulberry (Morus alba L.) dengan data kontrol disclosing solution tidak berbeda Konsentrasi yang tepat dari sari buah Mulberry (Morus alba L.) untuk dapat mewarnai plak gigi yaitu 100 %
AKTIVITAS LARVASIDA JAMUR Metarhizium anisopliae TERHADAP LARVA Aedes aegypti DI LABORATORIUM DAN UJI COBA LAPANGAN
Authors: Kurniawan Entuy , Mulia Yuliansyah Sundara , Dewi Novi Utami , Sanitavia Wahyu Hesti , Kristiyanti Yanuar 
Published: May 2022

Penggunaan insektisida sintesis (kimiawi) dalam penanggulangan vektor nyamuk menimbulkan beberapa masalah diantaranya dapat menimbulkan kerugian terhadap manusia (keracunan), resistensi terhadap serangga dan terjadinya pencemaran lingkungan. Cara mengurangi kerugian dampak negatif tersebut, yaitu dengan mengembangkan insektisida alami secara nabati dan biologi. Keuntungan penggunaan insektisida alami yaitu tidak mencemari lingkungan dan relatif aman bagi manusia. Salah satu insektisida biologi yang digunakan adalah jamur Metarhizium anisopliae yang mempunyai potensi untuk mengendalikan serangga pada stadium larva. Penelitian ini dilakukan untuk mengetahui efektivitas dari jamur Metarhizium anisopliae terhadap larva Aedes aegypti dibandingkan dengan larvasida standar Temephos di laboratorium dan di lapangan. Sampel berupa telur nyamuk dari spesies Aedes aegypti yang diperoleh dari Loka Litbang P2B2 Ciamis kemudian dibiakan menjadi larva instar III. Strain jamur Metarhizium anisopliae diperoleh dari Balai Proteksi Tanaman dan Perkebunan (BPTP) Ujung Berung, dibuat dalam berbagai konsentrasi melalui uji pendahuluan. Uji coba di lapangan dilakukan dalam skala kecil dengan cara meletakan tempat perindukan nyamuk (ovitrap). Aktivitas larvasida diukur dari jumlah kematian larva (LC50). Hasil penelitian menunjukkan bahwa aktivitas larvasida jamur Metarhizium anisopliae dengan jumlah kematian larva 50% (LC50) di laboratorium dan uji coba di lapangan terdapat pada konsentrasi 10-1 dengan jumlah spora di laboratorium sebesar 109.200 spora dan di lapangan adalah sebesar 81.750 spora. Hasil penelitian ini diharapkan Metarhizium anisopliae dapat digunakan sebagai insektisida alternatif untuk pengendalian vektor DBD.