bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of light regime and time of slaughter in broiler on broiler performance, liver antioxidant status, and expression of genes related to peptide absorption in the jejunum and melatonin synthesis in the brain
Authors: Pontes Mauricio Pires de , Khatlab Angélica de Souza , Del Vesco Ana Paula , Granzoto Gabriela Hernandes , Soares Maria Amélia Menck , Sousa Fabiana Cristina Belchior de , Souza Maria Luiza Rodrigues de , Gasparino Eliane 
Published: April 2022

AbstractThis study aimed to assess the effects of light regime and time of slaughter on primal cut and organ weights, peptide transporter 1 (PEPT1) gene expression in the jejunum, arylalkylamine N‐acetyltransferase (AANAT) gene expression in the brain, and liver oxidant/antioxidant status in broilers aged 37 days. The experiment was conducted in a factorial completely randomized design, with two light regimes (intermittent light varying according to bird age and continuous light under an 18 h light/6 h dark photoperiod) and four times of slaughter (2:00, 8:00, 14:00 and 20:00 h). There was an interaction effect on PEPT1 and AANAT expression, lipid and protein oxidation and superoxide dismutase (SOD) activity. In both light regimes, PEPT1 expression responded cubically to slaughter time. In the continuous light group, PEPT1 expression was highest in birds slaughtered at 2:00 and 14:00 h, whereas, in the intermittent light treatment, expression was highest at 8:00 h. In the continuous light regime, AANAT expression had a cubic relationship with time of slaughter, with the greatest values recorded at 20:00 h. In the intermittent light regime, slaughter time showed a cubic effect on lipid oxidation, which was highest at 8:00 h. In the continuous light group, there was a cubic effect on nitrite concentration, lipid oxidation, protein oxidation, and SOD activity; nitrite levels, lipid oxidation, and protein oxidation were highest and SOD activity was lowest in birds slaughtered at 14:00 h. Time of slaughter influenced catalase activity, which responded cubically; catalase activity was lowest at 8:00 and 14:00 h. This study is the first to demonstrate that PEPT1 expression in the jejunum of broilers follows a diurnal rhythm and varies according to light regime. The results also suggest that mainly continuous lighting and slaughter at 14:00 h when the animals are possibly more active may be more stressful to broilers.
Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea
Authors: Michnowska Alicja , Hart Samuel F. M. , Smolarz Katarzyna , Hallmann Anna , Metzger Michael J. 
Published: April 2022

AbstractDisseminated neoplasia (DN) is one of the most challenging and unrecognised diseases occurring in aquatic fauna. It has been diagnosed in four bivalve species from the Gulf of Gdańsk (Southern Baltic Sea) with the highest frequency in Macoma balthica (formerly Limecola balthica), reaching up to 94% in some populations. The aetiology of DN in the Baltic Sea has not yet been identified, with earlier studies trying to link its occurrence with environmental pollution. Taking into account recent research providing evidence that DN is horizontally transmitted as clonal cells between individuals in some bivalve species, we aimed to test whether DN is a bivalve transmissible neoplasia (BTN) in the population of M. balthica from the Gulf of Gdańsk highly affected with cancer. We examined mitochondrial cytochrome c oxidase I (mtCOI) and elongation factor 1α (EF1α) sequences of genomes obtained from haemolymph and tissues of neoplastic and healthy individuals. Sequence analysis resulted in detection of an independent transmissible cancer lineage occurring in four neoplastic clams that is not present in healthy animals. This study describes the first case of BTN in the clam M. balthica (MbaBTN), providing further insights for studies on this disease.
Effects of mild‐ and moderate‐intensity illumination on short‐term axial length and choroidal thickness changes in young adults
Authors: Chakraborty Ranjay , Baranton Konogan , Spiegel Daniel , Lacan Pascale , Guillon Matthias , Barrau Coralie , Villette Thierry 
Published: April 2022

AbstractPurposePrevious studies have shown that time spent outdoors is protective against myopia development in children. In this study, we examined the effects of 500 and 1000 lux of illumination to the eye on axial length (AL) and choroidal thickness (CT) changes in young adults.MethodsFifteen participants (mean age, 21.60 years [2.16]) with a mean refraction of −0.34 D (0.37) were exposed to 500 and 1000 lux of illumination for 120 min in a dark room on two different days, using a pair of light‐emitting glasses. Ocular measurements were repeated on an additional day in darkness (~5 lux). Ocular biometrics and CT were measured and analysed in the right eye before the light exposure (0 min), after 30, 60 and 120 min of exposure and 30 min after light offset to measure recovery using the Lenstar biometer and the Cirrus optical coherence tomographer, respectively.ResultsExposure to 500 and 1000 lux of illumination resulted in a significant reduction in AL at 30, 60 and 120 min compared to darkness (AL change at 120 min: darkness, +0.020 mm [0.004]; 500 lux, −0.006 mm [0.004]; 1000 lux, −0.013 mm [0.004]; p < 0.001). Exposure to 500 and 1000 lux caused a significant overall thickening of the subfoveal choroid compared to darkness (CT change across 120 min: darkness, −0.010 mm [0.007]; 500 lux, +0.006 mm [0.005]; 1000 lux, +0.009 mm [0.003], p = 0.02). Ocular changes were not significantly different between the two illumination levels (p > 0.05) and returned to baseline within 30 min of light offset.ConclusionsExposure to mild‐ or moderate‐intensity illumination on the eye can induce a significant short‐term reduction in AL and an increase in CT in young adults. Future studies on larger cohorts with varying light intensities are needed to better understand the effects of ocular illumination on AL changes in humans.
The OsEIL1‐OsERF115‐target gene regulatory module controls grain size and weight in rice
Authors: Liu Chang , Ma Tian , Yuan Dingyang , Zhou Yang , Long Yan , Li Ziwen , Dong Zhenying , Duan Meijuan , Yu Dong , Jing Yizhi , Bai Xiaoyue , Wang Yanbo , Hou Quancan , Liu Shuangshuang , Zhang Jin‐Song , Chen Shou‐Yi , Li Dayong , Liu Xue , Li Zhikang , Wang Wensheng , Li Jinping , Wei Xun , Ma Biao , Wan Xiangyuan 
Published: April 2022

SummaryGrain size is one of the essential determinants of rice yield. Our previous studies revealed that ethylene plays an important role in grain‐size control; however, the precise mechanism remains to be determined. Here, we report that the ethylene response factor OsERF115 functions as a key downstream regulator for ethylene‐mediated grain development. OsERF115 encodes an AP2/ERF‐type transcriptional factor that is specifically expressed in young spikelets and developing caryopses. Overexpression of OsERF115 significantly increases grain length, width, thickness and weight by promoting longitudinal elongation and transverse division of spikelet hull cells, as well as enhancing grain‐filling activity, whereas its knockout mutations lead to the opposite effects, suggesting that OsERF115 positively regulates grain size and weight. OsERF115 transcription is strongly induced by ethylene, and OsEIL1 directly binds to the promoter to activate its expression. OsERF115 acts as a transcriptional repressor to directly or indirectly modulate a set of grain‐size genes during spikelet growth and endosperm development. Importantly, haplotype analysis reveals that the SNP variations in the EIN3‐binding sites of OsERF115 promoter are significantly associated with the OsERF115 expression levels and grain weight, suggesting that natural variations in the OsERF115 promoter contribute to grain‐size diversity. In addition, the OsERF115 orthologues are identified only in grass species, implying a conserved and unique role in the grain development of cereal crops. Our results provide insights into the molecular mechanism of ethylene‐mediated grain‐size control and a potential strategy based on the OsEIL1‐OsERF115‐target gene regulatory module for genetic improvement of rice yield.
The history of buffy coat platelet concentrates: The Dutch story
Authors: van der Meer Pieter F. , Reesink Hendrik W. , de Korte Dirk , Loos Johannes A. , Klei Thomas R. L. 
Published: April 2022

AbstractThe buffy coat method as a source for platelet concentrates was developed in the 1970s and is still used in many blood centres around the world. Development of the method sparked various technological advances in blood collection, processing and storage. At the time, the need for platelet concentrates sharply increased because of better treatment regimens for (onco)haematological diseases, which forced blood centres to standardize and automate their production processes as much as the technology would allow. In this review, a historical overview of the Dutch experiences is provided in the context of the international developments.
Comparative Assessment of Falling-Film and Convective-Flow Absorption in Microscale Geometries
Authors: Nagavarapu Ananda Krishna , Garimella Srinivas 
Published: April 2022

Abstract
A comparative assessment between two modes for ammonia–water absorption, microchannel falling-film absorption and microscale convective-flow, is presented in this study. The microchannel falling-film absorber consists of an array of short microchannel tubes arranged parallel to each other and stacked in several vertical rows to provide the necessary transfer area. Dilute solution flows in a falling-film mode around these cooled tubes while absorbing the counter-current vapor. The microscale convective-flow absorber consists of an array of parallel, aligned alternating sheets with integral microscale features, enclosed between cover plates. Several absorber variants were designed for each flow configuration, and optimal prototypes were identified based on design and operational constraints for a 10.5 kW cooling capacity chiller. Comparative assessments of heat and mass transfer characteristics are presented while accounting for fabrication considerations. This work will guide the development of miniaturized absorption heat pump components.
Product Perceptual Similarity Evaluation: From Attributive Error to Human Knowledge Hierarchy
Authors: Jiang Wei , Zhao Wu , Du Lin , Zhang Kai , Yu Miao 
Published: April 2022

Abstract
A crucial part of any recommendation system for manufactured goods is the method used to evaluate the similarity of products. However, despite being central to the performance of many online retailers, current ways of evaluating product similarity are inconsistent with several characteristics of human perception and consequently often generate obvious errors when applied in practice. This paper proposes a new approach that uses the results of a perceptual evaluation of respondents to determine their “inherent knowledge hierarchy.” Using this characterization of the user, we propose a new strategy for determining the perceived similarity of products (PSIM strategy). After a preliminary verification of the proposed approach, we found that the performance of the PSIM strategy is much better than current strategies in terms of both accuracy and robustness. Beyond the application of PSIM in product recommendation systems, the findings of this study have the potential to help designers and companies better understand their customers’ emotional needs.
Ancient roots of tungsten in western North America
Authors: Elongo V. , Falck H. , Rasmussen K.L. , Robbins L.J. , Creaser R.A. , Luo Y. , Pearson D.G. , Sarkar C. , Adlakha E. , Palmer M.C. , Scott J.M. , Hickey K. , Konhauser K. , Lecumberri-Sanchez P. 
Published: April 2022

Abstract
The highly irregular and localized distribution of tungsten deposits worldwide constitutes a supply challenge for basic industries such as steel and carbides. Over Earth's history, tungsten has preferentially accumulated at paleocontinental margins formed during the breakup of supercontinents. Later crustal thickening of these paleogeographic regions and the magmas they produce are associated with large tungsten districts. However, all of the largest tungsten deposits in the modern North American Cordillera, which preserves over 3 b.y. of geologic record in a paleocontinental margin with abundant crustal magmatism, are limited to the narrow Canadian Tungsten Belt in northwestern Canada. We use neodymium isotopic compositions of scheelite (CaWO4) from the Canadian Tungsten Belt and the paleogeographic distribution of tungsten deposits in the North American Cordillera to constrain the factors that control tungsten distribution. We document that tungsten is specifically associated with materials that, on average, were derived from the mantle during the Mesoarchean to Paleoproterozoic. Weathering and erosion of the supercontinents Columbia and Rodinia favored pre-enrichment of tungsten in sediments. The orogenic heating of pre-enriched sediments produced reduced melts that were capable of efficiently scavenging tungsten and formed the largest deposits in North America.
Origin of Tibetan post-collisional high-K adakitic granites: Anatexis of intermediate to felsic arc rocks
Authors: Yi Jian-Kang , Zhu Di-Cheng , Weinberg Roberto F. , Wang Qing , Xie Jin-Cheng , Zhang Liang-Liang , Zhao Zhi-Dan 
Published: April 2022

Abstract
Potassium-rich adakitic rocks have been used to infer high-pressure (HP) melting of thickened or foundered mafic lower crust in post-collisional settings. However, their origin remains debated because of their potassic rather than sodic nature. We address this debate by investigating the source of post-collisional Oligocene high-K adakitic granites in southern Tibet, which are widely attributed to melting of overthickened mafic lower crust. Our new data provide evidence for the generation of these high-K adakitic granites by anatexis of exposed migmatitic intermediate to felsic arc orthogneisses. These granites contain high-Th/U Oligocene magmatic zircons (30−22 Ma), and inherited zircons (66−48 Ma) with the same εHf(t) (0 to +12) as the coeval migmatites. The migmatites have in turn low-Th/U metamorphic Oligocene zircon rims around 66−48 Ma magmatic zircon cores recording the anatectic event at 29−25 Ma. Phase equilibrium modeling yields an anatectic temperature of ~740 °C and pressure (P) of ~0.9 GPa and shows that garnet is stable at P &gt; 0.7 GPa in the melt-present field. The results indicate that high-K adakitic magmas are derived from melting of older intermediate to felsic arc rocks at intermediate pressures, in the garnet stability field, without any involvement of HP melting of metabasaltic rocks. We propose that hybridization between such purely crustal magmas and subcontinental lithospheric mantle–derived shoshonitic magmas results in the hybridized post-collisional Oligocene–Miocene mafic microgranular enclave–bearing potassic adakitic granitic rocks in southern Tibet.
Oxygen isotope evidence for progressively assimilating trans-crustal magma plumbing systems in Iceland
Authors: Caracciolo A. , Halldórsson S.A. , Bali E. , Marshall E.W. , Jeon H. , Whitehouse M.J. , Barnes J.D. , Guðfinnsson G.H. , Kahl M. , Hartley M.E. 
Published: April 2022

Abstract
The oxygen isotope composition of mantle-derived melts can place important constraints on how magmas are processed as they traverse the crust. Assimilation of crustal material is a crucial aspect of basalt petrogenesis, as it affects the chemical and rheological characteristics of eruptive magmas at active volcanoes. We report oxygen isotope (δ18O) and trace element (TE) data from a suite of well-characterized basaltic melt inclusions and groundmass glasses from the Bárðarbunga volcanic system in Iceland to assess how and where in the plumbing system crustal rocks interact with ascending magmas. While both melt inclusions and groundmass glasses record a large range in δ18O values (+3.2‰ to +6.4‰ and +2.6‰ to +5.5‰, respectively) groundmass glasses record lower values on average. Relationships between incompatible trace element (e.g., Zr/Nb) and oxygen isotope ratios are best explained with three-component mixing, where primary melts derived from depleted and enriched mantle components with distinct δ18O values mix and acquire a low-δ18O character upon progressive contamination with altered Icelandic crust. The majority (60%) of melt inclusions require 10–30% exchange of oxygen with the Icelandic crust. In addition, for the first time, we link the extent of oxygen isotope exchange with melt equilibration depths, showing that most of the contamination occurs at 1–2 kbar (3–7 km depth). We propose that a progressively assimilating, multi-tiered plumbing system is a characteristic feature of the Bárðarbunga volcanic system, whereby chemical modifications resulting from interaction with the crust systematically increase as melts migrate through higher crustal levels. We show that similar processes may also occur across the active rift zone in Iceland.
EFFORT study: Comparing impact of operation and assisted reproductive technologies on fertility for women with deep infiltrating endometriosis – study protocol for a multicentre randomised trial
Authors: Raos Maja , Roman Horace , Seyer-Hansen Mikkel , Kesmodel Ulrik Schiøler , Knudsen Ulla Breth 
Published: April 2022

IntroductionDeep infiltrating endometriosis (DIE) affecting the rectum or sigmoid colon is associated with infertility, severe pain and decreased quality of life. As most women with DIE are young, many have a pregnancy intention. Treatment possibilities of endometriosis-associated infertility are surgery or assisted reproductive technologies (ART). However, no studies have compared the two interventions directly. Therefore, this study aims to determine the cumulative pregnancy rate (CPR) and the live birth rate (LBR) after first-line surgery compared with first-line ART for women with rectosigmoid DIE and a pregnancy intention.Methods and analysisMulticentre, parallel-group, randomised trial of women with rectosigmoid DIE and a pregnancy intention for at least 6 months in Aarhus, Denmark and Bordeaux, France. 352 women aged 18–38 years are randomised 1:1 to either surgical management (shaving, disc excision or segmental resection) or ART management (at least two in vitro fertilisation or intracytoplasmic sperm injection procedures if not pregnant after the first cycle). Women in the surgical intervention group will attempt to get pregnant by either spontaneous conception or ART, depending on the endometriosis fertility index score. Primary outcome measures are CPR and LBR at 18 months’ follow-up. Secondary outcomes are: Non-viable pregnancies, time to pregnancy, pain score, quality of life, complication rate, bowel and bladder function, endocrine and inflammatory profile, number of oocytes, blastocysts, frozen embryos and blastocyst morphology score within 18 months after either intervention.Ethics and disseminationConduct of this study is approved by the Danish National Committee on Health Research Ethics and Comité de Protection des Personnes Ile de France VIII. Study participants must sign an informed consent form. The results will be presented at national and international conferences and published in international peer-reviewed journals.Trial registration numberThis trial is registered at ClinicalTrials.gov (no.NCT04610710).Protocol versionThe Danish National Committee on Health Research Ethics: Fifth protocol version approved 7 September 2020 (no. 1-10-72-96-20). Comité de Protection des Personnes Ile de France VIII: Version 1.1 22JAN2021 the 9 March 2021.
Mental health specialist video consultations for patients with somatic symptom disorder in primary care: protocol for a randomised feasibility trial (the VISION trial)
Authors: Haun Markus W , Tönnies Justus , Graue Leike , Hartmann Mechthild , Wensing Michel , Szecsenyi Joachim , Wild Beate , Friederich Hans-Christoph 
Published: April 2022

IntroductionGeneral practitioners (GP) report increasing difficulties in referring patients with somatic symptom disorder (SSD) in specialised psychosocial care. Barriers are structural conditions of the respective healthcare system and patients’ reservations against receiving specialised psychosocial care. As patients with SSD often predominantly assume somatic influencing factors for the development and maintenance of their somatic complaints, close collaboration between the GP and mental health specialist (MHS) seems particularly important. Integrating internet-based video consultations by remotely located MHS and primary care can improve effective treatment of patients with SSD by overcoming structural barriers and provide low-threshold and timely care. The aim of this randomised controlled feasibility trial is to investigate the feasibility of implementing MHS video consultations in primary care practices.Methods and analysisFifty primary care patients with SSD will be individually randomised in two groups receiving either enhanced treatment as usual as provided by their GP (control group) or two versus five video consultations conducted by an MHS additionally to enhanced treatment as usual. The video consultations focus on (a) diagnostic clarification, (b) the development of a biopsychosocial disorder model, and (c) development of a treatment plan against the background of a stepped-care algorithm based on clinical outcomes. We will investigate the following outcomes: effectiveness of the recruitment strategies, patient acceptance of randomisation, practicability of the technical and logistical processes related to implementing video consultations in the practices’ workflows, feasibility of the data collection and clinical parameters.Ethics and disseminationThis trial has undergone ethical scrutiny and has been approved by the Medical Faculty of the University of Heidelberg Ethics Committee (S-620/2021). The findings will be disseminated to the research community through presentations at conferences and publications in scientific journals. This feasibility trial will prepare the ground for a large-scale, fully powered randomised controlled trial.Trial registration numberDRKS00026075.