bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric study of obtaining furfural and hydroxymethyl furfural from sugarcane bagasse
Authors: Murillo Sandra Peña , Nevárez Eddie Zambrano , Durango Eduardo Arango 
Published: June 2022

Abstract

This electronic document is a bibliometric observational study describing the production of furfural and hydroxymethylfurfural from sugarcane bagasse during 2015–2021 and was used as the primary measure, with the magazine, year of publication, first/last author, workplace, and autonomous community as the direct measures. Subsequently, articles were classified according to their content or research area. The impact factor was obtained from the Scopus and VoS Viewer bibliometric analysis. The results are presented in various figures. Through the search criteria used, 639 documents were retrieved in the 2015–2021 six-year term, excluding 307 because they did not correspond to affiliation with centers or institutions directly related to papers related to furfural and hydroxymethylfurfural. A total of 49 documents were selected, and an increase in interest in studying these compounds was verified in the research and the journals in which they were published. Most studies have been published in universities or research centers, and differences were observed in the volume of international and national scientific production, making it necessary to increase these investigations in Colombia.
Antibody levels poorly reflect on the frequency of memory B cells generated following SARS-CoV-2, seasonal influenza, or EBV infection
Authors: Wolf Carla , Köppert Sebastian , Becza Noémi , Küerten Stefanie , Kirchenbaum Greg A. , Lehmann Paul V. 
Published: June 2022

Abstract
Assessment of humoral immunity is commonly confined to measurements of serum antibody reactivity. These pre-formed immunoglobulin molecules can convey immunity by preventing a re-infection. In some instances, however, a re-infection does occur, and in such cases, it is the mobilization of an anamnestic B and T cell response that confers immune protection. Relying on fundamentally different mechanisms, therefore, passive immunity conveyed by pre-existing antibodies needs to be distinguished from active B cell memory. Here, we tested whether in healthy human individuals the antibody titers to SARS-CoV-2, seasonal influenza, or Epstein-Barr virus antigens correlated with the frequency of memory B cells reactive with the respective antigens. Weak correlations were found. The data suggest that assessment of humoral immunity by measurement of antibody levels does not reflect on memory B cell frequencies, and thus an individual’s potential to engage into an anamnestic antibody response against the same or an antigenically-related virus. Direct monitoring of the antigen-reactive memory B cell compartment is both required and feasible towards that goal. Word Count = 166
Multivariate Bayesian VARX model application to forecast BTC volatility, volatility indices and its node user’s countries
Authors: Ahmed wajid 
Published: June 2022

Abstract
The study assesses the forecasting accuracy based on deterministic and stochastic techniques of bitcoin and its node users emerging and developed countries with respective volatility indices. The study suggested Morgan Stanley Composite Index (MSCI) data base for the sample period from January 2009 till April 2020. The study extend the guideline of Catania, Grassi, and Ravazzolo (2019) after introducing the Bayesian VARX model with Multivariate VARX approach for forecasting analysis. The findings suggest a strong pairwise unconditional relationship among the crypto currency and stock market indices and Granger cause it too. Stochastic forecasting technique completely dominate and confirms that the stochastic trend existed through the sample time periods. Whereas historical decomposition analysis in response to bitcoin shocks support the Bayesian VARX approach for all cases.JEL Code: C11, C53, C58
Improving health behaviors in food insecure college students through a cooking and gardening nutrition intervention
Authors: Macchi Alison , Coccia Catherine 
Published: June 2022

Abstract
ObjectiveThis randomized control trial aimed to determine the effect of a Social Cognitive Theory (SCT) based, urban gardening, cooking and nutrition education intervention on health behavior mediators and fruit and vegetable intake in food insecure college students.ParticipantsParticipants included 89 food insecure college students (86% female, 59% Hispanic) randomized into a control (n=42) or intervention group (n=47).InterventionIntervention participants attended a 6-week hands-on, cooking and gardening nutrition education program. Surveys and anthropometric measurements for both groups were assessed at baseline and post-intervention.ResultsStudents who participated in the intervention experienced a significant improvement in self-efficacy (F=17.65, P<.001), reciprocal determination (F=4.16, P=.045), personal (F=5.65, P=.020) and family (F=5.36, P=.023) health views, and increased fruit and vegetable intake (F=19.19, P<.001), when compared to students in the control group.Conclusions and ImplicationsA SCT based cooking and gardening nutrition program tailored to food insecure college students may help improve health behavior mediators and fruit and vegetable intake.
Analysis of Bipolar Disorder Using fMRI
Authors: Jiji Wiselin , A Muthuraj , Vijayan Catherine Praiseye , A Rajesh 
Published: June 2022

Abstract
In this work, we have analysed bipolar disorder using fMRI based on brain regional activity measurements. In this research work, we have located the eights regions as per the literature review which are strongly affected brain regions because of BPD. For those regions, the below operations are carried out. Initially functional points are identified using independent component analysis and their connectivity has been established using correlation coefficients. Then located the activated points using Hierarchical Modular Analysis based on the strength of the interregional connectivity. Followed by constructing network between the activated points of each brain regions. Property of network parameters like centrality page rank and centrality degree, centrality closeness, assortativity and clustering coefficients are extracted. Finally, adaboost classifier consist of three weak classifiers, KNN, GDA and naïve bayes are experimented. It was found that this work had given 94.2% accuracy comparatively better than earlier research works.
ESTRUTURA DE GOVERNANÇA CORPORATIVA EM EMPRESAS FAMILIARES
Authors: Schneider Leandro , Da Rosa Caroline , Knebel Baggio Daniel 
Published: June 2022

RESUMO
Nas últimas décadas, o conceito de governança corporativa vem se tornando uma preocupação tanto de mercados desenvolvidos como emergentes. A governança corporativa consiste no sistema pelo qual as organizações são dirigidas, monitoradas e incentivadas, envolvendo os relacionamentos entre sócios, conselho de administração, diretoria, órgãos de fiscalização e controle e demais partes interessadas. Qualquer tipo de organização pode se beneficiar dos princípios e das práticas de governança corporativa, inclusive as empresas familiares, que enfrentam desafios peculiares, tais como os conflitos de poder, as sucessões e a falta de controle e de liderança. Nesse sentido, o presente estudo busca compreender de que forma está estruturado o modelo de governança em uma empresa agroindustrial familiar do Rio Grande do Sul. A coleta de dados foi realizada a partir de uma entrevista semiestruturada com um diretor da organização, seguida de análise documental. Os dados foram tratados pela técnica de análise de conteúdo. Constatou-se que na organização estudada a estrutura de governança é reconhecida como um subsídio à gestão, possibilitando um maior controle sobre a gestão, o patrimônio e a família, bem como uma melhor organização da fiscalização, planejamento e execução das ações necessárias ao crescimento da organização.
Palavras-chave: Empresa familiar, Governança Corporativa, Agroindústria.
RELAÇÃO ENTRE GOVERNANÇA CORPORATIVA E RESTRIÇÃO FINANCEIRA EM EMPRESAS BRASILEIRAS
Authors: Augusto de Oliveira Silva Breno , Ferreira Caixe Daniel , Krauter Elizabeth 
Published: June 2022

RESUMO
Este estudo teve como objetivo investigar a relação entre governança corporativa e restrição financeira no Brasil. Com tal finalidade, foi construído um painel não balanceado formado por 248 companhias brasileiras ao longo de 2006 a 2015. A qualidade das práticas de governança foi medida por meio do Índice de Práticas de Governança Corporativa (IPGC), enquanto os índices KZ, WW e FCP foram usados como proxies para o grau de restrição financeira. Os resultados do teste de Mann-Whitney, do teste de correlação de Spearman e de modelos de regressão linear indicaram que há uma relação negativa entre qualidade da governança corporativa e restrição financeira. Esses resultados foram interpretados como uma evidência de que a adoção de melhores padrões de governança pode reduzir restrições financeiras ao mitigar assimetria informacional e conflitos de agência.
Palavras-chave: Governança corporativa, restrição financeira, IPGC.
CORPORATE GOVERNANCE: THE INTERNATIONAL JORNALL BUSINESS IN SOCIETY UMA ANALISE BIBLIOMÉTRICA DOS ANOS DE 2013 A 2018.
Authors: Faturi Silva Daniel , Fernando Moreira Luis , Schlindwein Carlos Eduardo , Eckert Alex 
Published: June 2022

RESUMO
O presente artigo teve como campo de pesquisa a governança corporativa. Uma boa governança corporativa vem se tornando algo essencial em empresas que buscam sucesso em mercados cada vez mais competitivos. Estudos que buscam aperfeiçoar esta temática, estão cada vez mais presentes no meio acadêmico. Com o objetivo de analisar a produção científica sobre governança corporativa, este documento propôs-se a analisar as 25 edições da revista Corporate Governance: The International Journal Business in Society entre os anos de 2013 a 2018 totalizando 238 artigos. A partir de um diagnóstico bibliométrico, o objetivo do estudo foi analisar a metodologia usada nos documentos, qualitativos ou quantitativos, e como resultado, identificou-se uma tendência a publicações quantitativas pois, 61% dos artigos são quantitativos. A pesquisa focou-se em analisar os 93 artigos qualitativos e após análise, estipulou-se trabalhar com os 10 artigos qualitativos que apresentam a técnica do estudo de caso. Verificou-se uma pluralidade nos 10 artigos analisados no que tange amostra utilizada, ambiência pública ou privada, indicação de limitações e estudos futuros.
Palavras-chave: Governança Corporativa. Diagnóstico bibliométrico. Estudo de caso.
Evaluating the performance of feature selection techniques and machine learning algorithms on future residential water demand
Authors: Pourmousavi Marziyeh , Nasrollahi Hossein , Najafabadi Abdolhamid Amirkaveh , Kalhor Ahmad 
Published: June 2022

AbstractThe provision of potable water as a severe challenge has engaged many people worldwide. So, identifying influential factors in water demand forecasting (WDF) for the residential sector performs a vital role in water crisis management. Nowadays, long-term macro-planning for vast geographical areas helps policymakers to achieve sustainable development goals. This study uses the same perspective to present a pattern for water consumption behavior and prediction. For this purpose, yearly residential water consumption data, along with climatic characteristics, and socioeconomic factors of rural areas of Isfahan, Iran, are aggregated. The feature selection task is conducted on the collected data using various machine learning (ML) methods along with a novel approach, forward selection based on smoothness index (FSSmI). Posterior to selecting features influencing residential water demand (WD), the raw data are analyzed using regression techniques, including multiple linear regression, support vector regression, and random forest regression. The employed methods show an improvement in the feature selection procedure and coefficient of determination as a result of implementing the FSSmI method. Based on the results, multiple linear regression and support vector regression gain 96% and 95% accuracy and less than 11% and 13% error respectively; it demonstrates the validity of forecasting methods.
Effect of carbohydrates on protein hydrolysis in anaerobic digestion
Authors: Duong Thu Hang , van Eekert Miriam , Grolle Katja , Tran Thi Viet Nga , Zeeman Grietje , Temmink Hardy 
Published: June 2022

Abstract
This study aimed to assess the effect of carbohydrates on protein hydrolysis and potential implications for the design of anaerobic reactors for treatment of protein-rich wastewaters. Batch experiments were carried out with dissolved starch (Sta) and gelatine (Gel) at different chemical oxygen demand (COD) ratios ranging from 0 to 5.5 under methanogenic conditions for methane production and up to 3.8 under non-methanogenic conditions for volatile fatty acids (VFA), both at 35 °C. The Sta/Gel did not have a direct effect on the gelatine hydrolysis rate constants under methanogenic (0.51 ± 0.05 L g VSS−1 day−1) and non-methanogenic conditions (0.48 ± 0.05 L g VSS−1 day−1). However, under non-methanogenic conditions, gelatine hydrolysis was inhibited by 64% when a spectrum of VFA was added at a VFA/Gel (COD) ratio of 5.9. This was not caused by the ionic strength exerted by VFA but by the VFA itself. These results imply that methanogenesis dictates the reactor design for methane production but hydrolysis does for VFA production from wastewater proteins.
Modelo teórico microeconômico do consumo de turismo
Authors: De Oliveira Santos Glauber Eduardo 
Published: June 2022

Desenvolve um modelo teórico para explicar a decisão de viajar e a despesa turística com base nos conceitos e princípios da teoria microeconômica do comportamento do consumidor. As escolhas são explicadas como consequências das preferências individuais relativas ao consumo de serviços turísticos no destino, ao transporte entre o local de residência e o destino, e ao consumo de bens e serviços não turísticos. Também compõem o modelo a disponibilidade de recursos financeiros e os preços. A relação entre o consumo de transporte e o consumo no destino constitui uma restrição adicional decorrente da natureza espacial das viagens turísticas. O modelo abandona a hipótese de separabilidade das decisões adotada por trabalhos anteriores. Além disso, a utilidade positiva ou negativa do transporte é acrescentada ao arcabouço teórico. A proposta é capaz de explicar a distribuição típica dos indivíduos e famílias segundo suas despesas turísticas, incluindo a grande massa de zeros e a distribuição dos valores positivos em forma de sino com assimetria positiva. O modelo também contribui para a seleção de variáveis e métodos para a análise empírica do consumo turístico. Em especial, o modelo teórico oferece suporte ao uso do modelo econométrico para amostras seletivas de Heckman na estimação da despesa turística.
Palavras-chave: Microeconomia. Comportamento do Turista. Propensão a Viajar. Despesa Turística. Gasto Turístico. Modelo Teórico.
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of
Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans
Authors: Talapphetsakun Taman , Viyoch Jarupa , Waranuch Neti , Sermsappasuk Pakawadee 
Published: June 2022

Background:
Andrographolide has a potent antiviral effect in the treatment of coronavirus disease
(COVID-19). However, there are no in vivo studies of andrographolide as an anti-COVID-19 treatment.

Objective:
The study aims to develop a physiologically based pharmacokinetic (PBPK) animal model and scale it up
to a human model to predict andrographolide concentrations in the lungs.

Method:
ADAPT5 (version 5.0.58) was used to establish the PBPK model based on 24 enrolled pharmacokinetic
studies.

Results:
The perfusion-limited PBPK model was developed in mice and extrapolated to rats, dogs, and humans. The
metabolism of andrographolide in humans was described by the Michaelis-Menten equation. The saturation of the
metabolism occurred at a high dose (12 g), which could not be used therapeutically. The optimized oral bioavailability
in humans was 6.3%. Due to the limit of solubility, the dose-dependent absorption between 20-1000 mg was
predicted by GastroPlus®. Using the extrapolated human PBPK model together with the predicted dose-dependent
fraction of the dose absorbed that enters the enterocytes by GastroPlus®, the oral dosage of 200 mg q8h of andrographolide
would provide a trough level of free andrographolide at a steady state over the reported IC50 value against
SARS-CoV-2 in the lungs for the majority of healthy humans. Based on the reported CC50 value, toxicity might not
occur at the therapeutic dosage.

Conclusion:
The PBPK model of andrographolide in animals and humans was successfully constructed. Once additional
data is available, the model would be needed to recalibrate to gain an understanding of a dose-response relationship
and optimization of dosage regimens of andrographolide.
Landscape Determinants of Infectivity and Insights into Vaccine Development
and Effectiveness - Novel Coronavirus
Authors: Hasan Saba , Dwivedi Manish , Mukhopadhyay Sutanu , Gupta Nandini 
Published: June 2022

Abstract:
Novel technology has led to advanced approaches and understandings of viral biology, and the
advent in previous years has raised the possibility of determination of mechanisms of viral replication and
infection, trans-species adaption, and disease. The outbreak of Coronavirus 2019 (COVID-19) has become a global life-threatening concern recently. The war against COVID19 has now reached the most
critical point, whereby it has caused worldwide social and economic disruption. Unfortunately, limited
knowledge persists among the community regarding the biology of SARS-CoV-2 infection. The present
review will summarize the basic life cycle and replication of the well-studied coronaviruses, identifying
the unique characteristics of coronavirus biology and highlighting critical points where research has made
significant advances that might represent targets for antivirals or vaccines. Areas where rapid progress has
been made in SARS-CoV research have been highlighted. Additionally, an overview of the efforts dedicated to an effective vaccine for this novel coronavirus, particularly different generations of vaccines,
which has crippled the world, has also been discussed. Areas of concern for research in coronavirus replication, genetics, and pathogenesis have been explained as well. Speedy evaluation of multiple approaches
to elicit protective immunity and safety is essential to curtail unwanted immune potentiation, which plays
an important role in the pathogenesis of this virus. Hope is to provide a glimpse into the current efforts,
and the progress is made with reference to Coronaviruses and how the community can work together to
prevent and control coronavirus infection now and in the future.
Target Blood Pressure and Combination Therapy: Focus on Angiotensin
Receptor Blockers Combination with Either Calcium Channel Blockers or
Beta Blockers
Authors: Farag Selvia M. , Rabea Hoda M. , Abdelrahim Mohamed EA , Mahmoud Hesham B. 
Published: June 2022

Background:
The target blood pressure has changed many times in the guidelines in past
years. However, there is always a question; is it good to lower blood pressure below 120/80 or not?
Control of blood pressure in hypertension is very important in reducing hypertension-modified organ
damage. So, the guidelines recommend combining more than one antihypertensive drug to
reach the target blood pressure goal.

Results:
Combination therapy is recommended by guidelines to reach the blood pressure goal. The
guidelines recommend many combinations, such as the combination of angiotensin receptor blockers
with either calcium channel blockers (CCB) or beta-blocker (BB). Angiotensin receptor blocker
(ARB) combination with CCB has gained superiority over other antihypertension drug combinations
because it reduces blood pressure and decreases the incidence of CV events and organ damage.
BB combinations are recommended by guidelines in patients with ischemic events but not all
hypertensive patients. Unfortunately, the new generation BB, for example, nebivolol, has a vasodilator
effect, making it new hope for BB.

Conclusion:
Combination therapy is a must in treating the hypertensive patient. The new generation
BBs may change the recommendations of guidelines because they have an effect that is similar to
CCBs.
Aluminum Phosphide Poisoning in the North of Iran: A Register-based
Research
Authors: Kojidi Hamid Mohammadi , Attarchi Mirsaeed , Rahbar-Taramsari Morteza , Badsar Alireza , Faraji Niloofar , Rastak Yalda , Ebrahim-Saraie Hadi Sedigh 
Published: June 2022

Background:
Aluminum phosphide (ALP) poisoning is considered one of the health
care issues in Iran, which is associated with the mortality outcome of patients.

Introduction:
According to the ALP poisoning that commonly results in death, we aimed to
evaluate the prevalence of ALP pill poisoning by employing register-based research.

Methods:
In this descriptive cross-sectional study, all selected patients diagnosed and confirmed
with ALP poisoning by a specialist and referred to the poisoning ward from the beginning of April
2016 to the end of October 2017 were enrolled, and data were registered in the Disease
Registration System by a technical expert for daily follow-up during hospitalization.

Results:
Approximately 12.4% of patients had neurological problems, with the majority having
paresis (68.3%). Self-poisoning with the purpose of suicide was documented for 96.2% of cases,
with the most common cause being family problems (54.1%). In 97.3% of cases, the method of
contact with the toxic substance was oral. Hypotension, cardiac, and respiratory complications
were observed in 25.2%, 30.8%, and 25% of the patients, respectively. The most gastrointestinal
symptoms were nausea and vomiting (86.7%).

Conclusion:
The results indicate that the rate of ALP pill poisoning is relatively high. Suicide is
the most important cause of ALP poisoning, which is more common in men under 40 years of age.