bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambient water quality criteria derived using probabilistic risk assessment
Authors: Barnhart Brad , Flinders Camille , Johnson Giffe , Wiegand Paul , Anderson Paul , Morrison Emily , Houck Gina 
Published: September 2022

Abstract
National recommendations for numeric human health ambient water quality criteria (AWQC) for toxic substances are derived by the US Environmental Protection Agency (USEPA) using a deterministic approach that combines point estimates for exposure, toxicity, and acceptable risk. In accordance with the Clean Water Act, states, territories, and authorized tribes must either adopt these recommendations or modify and replace them with criteria using an alternative, scientifically defensible method. Recent reports have criticized the deterministic approach, stating that it suffers from compounded conservatism by selecting upper percentiles or maximum values for multiple inputs and that it cannot directly determine what portion of the population a given criterion protects. As an alternative, probabilistic risk assessment (PRA) has been promoted as a more transparent and robust method for deriving AWQC. Probabilistic risk assessment offers several advantages over the deterministic approach. For example, PRA uses entire data distributions rather than upper-percentile point estimates to specify exposures, thereby reducing compounded conservatism. Additionally, because it links acceptable risk targets with specific segments of the exposed population, PRA-based AWQC demonstrably protects multiple subsets of the population. To date, no study has quantitatively compared deterministic and PRA approaches and resulting AWQC using national inputs consistent with USEPA guidance. This study introduces a PRA method for deriving AWQC and presents case studies to compare probabilistically derived AWQC with USEPA's 2015 recommendations. The methods and results of this work will help federal and state regulators, water quality managers, and stakeholders better understand available approaches to deriving AWQC and provide context to assumption- and method-specific differences between criteria. Integr Environ Assess Manag 2023;19:501–512. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Germline gain‐of‐function MMP11 variant results in an aggressive form of colorectal cancer
Authors: Martin‐Morales Lorena , Manzano Sara , Rodrigo‐Faus Maria , Vicente‐Barrueco Adrian , Lorca Victor , Núñez‐Moreno Gonzalo , Bragado Paloma , Porras Almudena , Caldes Trinidad , Garre Pilar , Gutierrez‐Uzquiza Alvaro 
Published: September 2022

AbstractMatrix metalloproteinase‐11 (MMP11) is an enzyme with proteolytic activity against matrix and nonmatrix proteins. Although most MMPs are secreted as inactive proenzymes and are later activated extracellularly, MMP11 is activated intracellularly by furin within the constitutive secretory pathway. It is a key factor in physiological tissue remodeling and its alteration may play an important role in the progression of epithelial malignancies and other diseases. TCGA colon and colorectal adenocarcinoma data showed that upregulation of MMP11 expression correlates with tumorigenesis and malignancy. Here, we provide evidence that a germline variant in the MMP11 gene (NM_005940: c.232C>T; p.(Pro78Ser)), identified by whole exome sequencing, can increase the tumorigenic properties of colorectal cancer (CRC) cells. P78S is located in the prodomain region, which is responsible for blocking MMP11's protease activity. This variant was detected in the proband and all the cancer‐affected family members analyzed, while it was not detected in healthy relatives. In silico analyses predict that P78S could have an impact on the activation of the enzyme. Furthermore, our in vitro analyses show that the expression of P78S in HCT116 cells increases tumor cell invasion and proliferation. In summary, our results show that this variant could modify the structure of the MMP11 prodomain, producing a premature or uncontrolled activation of the enzyme that may contribute to an early CRC onset in these patients. The study of this gene in other CRC cases will provide further information about its role in CRC development, which might improve patient treatment in the future.
Stock returns, government response strategies, and daily new case bursts during COVID‐19: A cross‐country perspective
Authors: Bilal  , Nasir Adeel , Farooq Umar , Bashir Muhammad Farhan 
Published: September 2022

AbstractThe purpose of the current research is to examine the influence of COVID‐19 pandemic related governmental policies and the bursts (e.g., drastic increases in cases during certain periods) of COVID‐19 cases on the abnormal returns of 725 hospitality and entertainment companies from the United States (US), China, the United Kingdom (UK), India, Thailand, Turkey, Mexico, and France. The study uses daily data from January 1, 2020, to November 20, 2021 and event study methodology. Our results offer the following insights. First, the response in the early days of COVID‐19 was negative for both the hospitality and entertainment sectors. Second, regarding government response strategies: (1) announcements of stimulus packages negatively affected China's entertainment and the UK's hospitality and entertainment sectors, but positively impacted the US's hospitality sector; (2) lockdown announcements adversely affected abnormal returns only in the US's hospitality and entertainment sectors; and (3) travel restrictions affected the US hospitality and Chinese and Indian entertainment sectors in the early stages of the pandemic. Third, regarding COVID‐19 case bursts, the results showed more negative abnormal returns during the first burst in the developed countries compared to undeveloped countries, while in the second burst, investors reacted more rationally, resulting in less negative abnormal returns. Conversely, more negative abnormal returns were found in the second bursts in India and Turkey. We conclude that COVID‐19's impact differed between developed and developing countries. Our findings suggest that investors should consider these differential effects when devising their portfolio strategies during COVID‐19 or the similar situations.
Distinct Responses of Modeling- and Remodeling-Based Bone Formation to the Discontinuation of Intermittent Parathyroid Hormone Treatment in Ovariectomized Rats
Authors: Wang Wenzheng , Azar Tala , Tseng Wei-Ju , Pei Shaopeng , Zhou Yilu , Jiang Xi , Dyment Nathaniel , Liu X. Sherry 
Published: September 2022

ABSTRACT
Anabolic agents, such as intermittent parathyroid hormone (PTH), exert their treatment efficacy through activation of two distinct bone formation processes, namely, remodeling-based bone formation (RBF, bone formation coupled with prior bone resorption) and modeling-based bone formation (MBF, bone formation without prior activation of bone resorption). However, if not followed by an antiresorptive agent, treatment benefit was quickly lost upon withdrawal from anabolic agents. By using in vivo micro–computed tomography imaging and multiplex cryohistology with sequential immunofluorescence staining, we investigated the temporal response of newly formed bone tissue from MBF and RBF and the preexisting bone tissue to withdrawal from PTH treatment and the associated cellular activity in an ovariectomized (OVX) rat model. We first demonstrated continued mineral apposition at both RBF and MBF sites following PTH discontinuation, resulting in an extended anabolic effect after 1-week withdrawal from PTH. It was further discovered that MBF sites had a greater contribution than RBF sites to the extended anabolic effect upon early withdrawal from PTH, evidenced by a higher percentage of alkaline phosphatase-positive (ALP+) surfaces and far greater bone formation activity at MBF versus RBF sites. Furthermore, significant bone loss occurred after 3 weeks of discontinuation from PTH, resulting from marked loss of newly formed bone tissue from RBF and preexisting bone tissue prior to treatment. In contrast, MBF surfaces had a delayed increase of tartrate-resistant acid phosphatase activity following PTH discontinuation. As a result, newly formed bone tissue from MBF had greater resistance to PTH discontinuation–induced bone loss than those from RBF and preexisting bone. Understanding various responses of two distinct bone formation types and preexisting bone to anabolic treatment discontinuation is critical to inform the design of follow-up treatment or cyclic treatment strategies to maximize treatment benefit of anabolic agents. © 2022 American Society for Bone and Mineral Research (ASBMR).
Path integral Brownian chain molecular dynamics: A simple approximation of quantum vibrational dynamics
Authors: Shiga Motoyuki 
Published: September 2022

AbstractAn approximate approach to quantum vibrational dynamics, “Brownian chain molecular dynamics (BCMD),” is proposed to alleviate the chain resonance and curvature problems in the imaginary time‐based path integral (PI) simulation. Here the non‐centroid velocity is randomized at each step when solving the equation of motion of path integral molecular dynamics. This leads to a combination of the Newton equation and the overdamped Langevin equation for the centroid and non‐centroid variables, respectively. BCMD shares the basic properties of other PI approaches such as centroid and ring polymer molecular dynamics: It gives the correct Kubo‐transformed correlation function at short times, conserves the time symmetry, has the correct high‐temperature/classical limits, gives exactly the position and velocity autocorrelations of harmonic oscillator systems, and does not have the zero‐point leakage problem. Numerical tests were done on simple molecular models and liquid water. On‐the‐fly ab initio BCMD simulations were performed for the protonated water cluster, , and its isotopologue, .
Assessing transmission risks and control strategy for monkeypox as an emerging zoonosis in a metropolitan area
Authors: Yuan Pei , Tan Yi , Yang Liu , Aruffo Elena , Ogden Nicholas H. , Bélair Jacques , Heffernan Jane , Arino Julien , Watmough James , Carabin Hélène , Zhu Huaiping 
Published: September 2022

AbstractTo model the spread of monkeypox (MPX) in a metropolitan area for assessing the risk of possible outbreaks, and identifying essential public health measures to contain the virus spread. The animal reservoir is the key element in the modeling of zoonotic disease. Using a One Health approach, we model the spread of the MPX virus in humans considering potential animal hosts such as rodents (e.g., rats, mice, squirrels, chipmunks, etc.) and emphasize their role and transmission of the virus in a high‐risk group, including gay and bisexual men‐who‐have‐sex‐with‐men (gbMSM). From model and sensitivity analysis, we identify key public health factors and present scenarios under different transmission assumptions. We find that the MPX virus may spill over from gbMSM high‐risk groups to broader populations if the efficiency of transmission increases in the higher‐risk group. However, the risk of outbreak can be greatly reduced if at least 65% of symptomatic cases can be isolated and their contacts traced and quarantined. In addition, infections in an animal reservoir will exacerbate MPX transmission risk in the human population. Regions or communities with a higher proportion of gbMSM individuals need greater public health attention. Tracing and quarantine (or “effective quarantine” by postexposure vaccination) of contacts with MPX cases in high‐risk groups would have a significant effect on controlling the spreading. Also, monitoring for animal infections would be prudent.
IL‐12p40 promotes secondary damage and functional impairment after spinal cord contusional injury
Authors: Rosas Almanza Jose , Stehlik Kyle E. , Page Justin J. , Xiong Shuana H. , Tabor Emma G. , Aperi Brandy , Patel Kishan , Kodali Rajiv , Kurpad Shekar , Budde Matthew D. , Tarima Sergey , Swartz Karin , Kroner Antje 
Published: September 2022

AbstractSecondary damage obstructs functional recovery for individuals who have sustained a spinal cord injury (SCI). Two processes significantly contributing to tissue damage after trauma are spinal cord hemorrhage and inflammation: more specifically, the recruitment and activation of immune cells, frequently driven by pro‐inflammatory factors. Cytokines are inflammatory mediators capable of modulating the immune response. While cytokines are necessary to elicit inflammation for proper healing, excessive inflammation can result in destructive processes. The pro‐inflammatory cytokines IL‐12 and IL‐23 are pathogenic in multiple autoimmune diseases. The cytokine subunit IL‐12p40 is necessary to form bioactive IL‐12 and IL‐23. In this study, we examined the relationship between spinal cord hemorrhage and IL‐12‐related factors, as well as the impact of IL‐12p40 (IL‐12/IL‐23) on secondary damage and functional recovery after SCI. Using in vivo magnetic resonance imaging and protein tissue analyses, we demonstrated a positive correlation between IL‐12 and tissue hemorrhage. Receptor and ligand subunits of IL‐12 were significantly upregulated after injury and colocalized with astrocytes, demonstrating a myriad of opportunities for IL‐12 to induce an inflammatory response. IL‐12p40−/− mice demonstrated significantly improved functional recovery and reduced lesion sizes compared to wild‐type mice. Targeted gene array analysis in wild‐type and IL‐12p40−/− female mice after SCI revealed an upregulation of genes associated with worsened recovery after SCI. Taken together, our data reveal a pathogenic role of IL‐12p40 in the secondary damage after SCI, hindering functional recovery. IL‐12p40 (IL‐12/IL‐23) is thus an enticing neuroinflammatory target for further study as a potential therapeutic target to benefit recovery in acute SCI.
Projections of future precipitation and air temperature over the Tibetan Plateau based on Coupled Model Intercomparison Project Phase 6 multimodel ensembles
Authors: Zhang Wenqing , Liu Liu , Lun Yurui , Cheng Lei , Li Xiuping , Xu Zongxue 
Published: September 2022

AbstractIn the context of global warming and the release of projection results from the Coupled Model Intercomparison Project Phase 6 (CMIP6), it is important to conduct research on climate change on the Tibetan Plateau (TP) which exhibits unique geographic characteristics and complex climatic conditions. Using 10 general circulation models (GCMs) from CMIP6 corrected for bias by the daily translation (DT) method, we investigated the projected changes in precipitation and air temperature for the mid‐term (2031–2050) and long‐term (2061–2080) of the 21st century on the TP after evaluating the reliability of the bias correction, for four scenarios based on different combinations of shared socioeconomic pathways and representative concentration pathways. The multimodel ensembles (MMEs) indicated that the projected annual precipitation shows an increasing trend for the mid‐term and long‐term periods, with the projected increase for the long‐term primarily concentrated in areas with less precipitation. Meanwhile, the future precipitation changes exhibit a significant elevation dependency. The rate of increase of precipitation firstly fluctuates and then gradually increases along with the elevation increasing from 1,500 to 5,800 m. The valley value of rate mainly appears in two elevation zones (2,200–2,600 m and 3,400–3,800 m). The projected temporal changes in annual air temperatures reveal obvious warming over the TP. The projected warming is overall more pronounced with increase in elevation; however, it reaches a peak at approximately 5,000–5,200 m and then slows down slightly, indicating that warming is not dependent on elevation in the higher elevation zones. The present results have important implications for investigating the impacts of climate change on the water cycle in alpine regions.
Forecasting the cloud point of alkoxylated nonionic surfactants
Authors: Nilles Jan , Myrdek Thomas 
Published: September 2022

AbstractThe highest effectiveness of detergency for nonionic surfactants is observed in the proximity of the cloud point. This phenomenon is primarily influenced by surfactant molecular structure, such as carbon chain length and type of the hydrophilic components. Target of this investigation is to identify a relationship between the cloud point and the structure of nonionic surfactants based on ethoxylated (CnEm), ethoxylated‐propoxylated (CnEmPp) and propoxylated‐ethoxylated (CnPpEm) fatty alcohols. Three hundred and fifty nonionic surfactants have been prepared for this purpose. These surfactants differ in the C‐chain lengths, C4/C6 to C20/C22, and the amount of ethylene oxide (EO range [n] 2–22 ethoxylation) and propylene oxide (PO range [p] 0–12 propoxylation) moieties. Mapping the differences in the performance allows us to propose a high‐accuracy topological model describing the structure influence on the cloud point.
Highly‐Sensitive, Stable, and Fast‐Response Lead‐Free Cs2AgBiBr6 Double Perovskite Photodetectors Enabled by Synergistic Engineering of Doping Na+/Ce3+ and Integrating Ag Nanoparticles Film
Authors: Ding Nan , Shao Long , Xie Tianyu , Pan Gencai , Zhou Donglei , Bai Xue , Lu Siyu , Hu Junhua , Zhou Ji , Xu Wen , Song Hongwei 
Published: September 2022

AbstractLead‐free double halide perovskites stand out as a promising material for constructing stable and environmental‐friendly photodetectors (PDs) because of the excellent stability and nontoxicity. However, the performance (e.g., detectivity and response speed) of lead‐free double halide perovskites based PDs is still low. Herein, highly sensitive, stable, and fast‐response Cs2AgBiBr6 perovskite PDs are presented by synergistic engineering of doping optimization of Na+/Ce3+ and integrating with Ag nanoparticles (NPs). Compared to pristine Cs2AgBiBr6, Cs2AgBiBr6:Na+,Ce3+ film is endowed with higher crystallization quality and better stability after Na+,Ce3+ codoping, toward the reduced defect density, the improved charge mobility. Meanwhile, a significantly enhanced charge extraction and transport in Cs2AgBiBr6:Na+,Ce3+/Ag NPs hybrid film is achieved by further integrating with Ag NPs. Finally, Cs2AgBiBr6:Na+,Ce3+/Ag NPs hybrid film‐based PDs are developed, delivering high detectivity of 1.34 × 1012 Jones@460 nm and 1.18 × 1012 Jones@370 nm, which is the relatively high in lead‐free double halide perovskites PDs and exceeds the most results of the previous reports in the ultraviolet and visible range. The devices also show outstanding stability and fast‐response time (395 ns). This work opens up a novel frontier for developing lead‐free perovskite PDs.
NIfTI‐MRS: A standard data format for magnetic resonance spectroscopy
Authors: Clarke William T. , Bell Tiffany K. , Emir Uzay E. , Mikkelsen Mark , Oeltzschner Georg , Shamaei Amirmohammad , Soher Brian J. , Wilson Martin 
Published: September 2022

PurposeMultiple data formats in the MRS community currently hinder data sharing and integration. NIfTI‐MRS is proposed as a standard spectroscopy data format, implemented as an extension to the Neuroimaging informatics technology initiative (NIfTI) format. This standardized format can facilitate data sharing and algorithm development as well as ease integration of MRS analysis alongside other imaging modalities.MethodsA file format using the NIfTI header extension framework incorporates essential spectroscopic metadata and additional encoding dimensions. A detailed description of the specification is provided. An open‐source command‐line conversion program is implemented to convert single‐voxel and spectroscopic imaging data to NIfTI‐MRS. Visualization of data in NIfTI‐MRS is provided by development of a dedicated plugin for FSLeyes, the FMRIB Software Library (FSL) image viewer.ResultsOnline documentation and 10 example datasets in the proposed format are provided. Code examples of NIfTI‐MRS readers are implemented in common programming languages. Conversion software, spec2nii, currently converts 14 formats where data is stored in image‐space to NIfTI‐MRS, including Digital Imaging and Communications in Medicine (DICOM) and vendor proprietary formats.ConclusionNIfTI‐MRS aims to solve issues arising from multiple data formats being used in the MRS community. Through a single conversion point, processing and analysis of MRS data are simplified, thereby lowering the barrier to use of MRS. Furthermore, it can serve as the basis for open data sharing, collaboration, and interoperability of analysis programs. Greater standardization and harmonization become possible. By aligning with the dominant format in neuroimaging, NIfTI‐MRS enables the use of mature tools present in the imaging community, demonstrated in this work by using a dedicated imaging tool, FSLeyes, for visualization.
Reduction of the cardiac pulsation artifact and improvement of lesion conspicuity in flow‐compensated diffusion images in the liver—A quantitative evaluation of postprocessing algorithms
Authors: Führes Tobit , Saake Marc , Lorenz Jennifer , Seuss Hannes , Stemmer Alto , Benkert Thomas , Uder Michael , Laun Frederik Bernd 
Published: September 2022

PurposeTo enhance image quality of flow‐compensated diffusion‐weighted liver MRI data by increasing the lesion conspicuity and reducing the cardiac pulsation artifact using postprocessing algorithms.MethodsDiffusion‐weighted image data of 40 patients with liver lesions had been acquired at 1.5 T. These data were postprocessed with 5 different algorithms (weighted averaging, p‐mean, percentile, outlier exclusion, and exception set). Four image properties of the postprocessed data were evaluated for optimizing the algorithm parameters. These properties were the lesion to tissue contrast‐to‐noise ratio (CNR), the reduction of the cardiac pulsation artifact, the data consistency, and the vessel darkness. They were combined into a total quality score ( set to 1 for the trace‐weighted reference image), which was used to rate the image quality objectively.ResultsThe weighted averaging algorithm performed best according to the total quality score (). The further ranking was outlier exclusion algorithm (), p‐mean algorithm (), percentile algorithm (), and exception set algorithm (). All optimized algorithms except for the exception set algorithm corrected the pulsation artifact and increased the lesion CNR. Changes in were significant for all optimized algorithms except for the percentile algorithm. Liver ADC was significantly reduced (except for the exception set algorithm), particularly in the left lobe.ConclusionPostprocessing algorithms should be used for flow‐compensated liver DWI. The proposed weighted averaging algorithm seems to be suited best to increase the image quality of artifact‐corrupted flow‐compensated diffusion‐weighted liver data.
Mediastinal infantile hemangioma with spinal canal extension and extensive gastrointestinal involvement complicated by respiratory failure
Authors: Cohen‐Cutler Sally , Detterich Jon A. , Miller Joseph M. , Anselmo Dean M. , Luu Minnelly , Mascarenhas Leo 
Published: September 2022

AbstractInfantile hemangioma is the most common soft tissue tumor of infancy. Extensive organ involvement is rare. This report describes an infant with biopsy confirmed infantile hemangioma with diffuse organ involvement causing anemia and failure to thrive. Treatment was initiated with propranolol and led to initial improvement; however, course was complicated by several episodes of respiratory failure secondary to pulmonary edema. Propranolol therapy was interrupted for several months while patient was maintained on a diuretic regimen and treated with vincristine and high‐dose corticosteroids. Patient was transitioned back to propranolol and is clinically thriving with objective improvement on radiographic imaging.