bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐dose proton radiotherapy for pediatric choroidal hemangioma: A case series
Authors: Franco Jovany J. , Liu Kevin X. , Ioakeim‐Ioannidou Myrsini , Davila Jose R. , Chen Yen‐Lin , Kim Ivana K. , Gragoudas Evangelos S. , Mukai Shizuo , MacDonald Shannon M. 
Published: August 2022

AbstractManagement of pediatric choroidal hemangioma complicated by large exudative retinal detachment can be challenging, with few options available. Limited data have been published on outcomes following proton radiotherapy (PRT) for management of these patients. In this retrospective case series, nine patients were treated with a low‐dose PRT regimen of 20 Gy(relative biological effectiveness [RBE]) in 10 fractions, and two were treated with 15 Gy(RBE) in four fractions. Visual acuity improved in seven patients (64%) and remained stable in the remaining four (36%). In patients with imaging follow‐up (10 patients), subretinal fluid resolved in nine patients (90%) and tumor thickness decreased or remained stable in 10 (100%). Complications were observed in eight of 11 patients (73%). One patient developed grade 2 cataract; otherwise, no grade ≥2 complications were observed.
The role of clinical and Personological features in predicting high lethality suicide attempts: A study among mood disorder patients
Authors: Borroni Serena , Franchini Linda , Brioschi Silvia , Vassena Giulia , Masci Elisabetta , Franzoni Chiara , Ruotolo Giulia , Colombo Cristina , Fossati Andrea 
Published: August 2022

AbstractSuicidal attempts (SA) represent heterogeneous behaviours ranging in their seriousness from fatal and near‐fatal (high‐lethality) cases to those that do not require medical attention (low lethality). These considerations stress the need to identify high‐risk individuals for high lethality SA in order to target suicide preventive interventions. The present study aims at evaluating the role of sociodemographic and clinical variables and examining personality pathological features in predicting high lethality SA. The sample was composed by 94 patients who were consecutively admitted to the Mood Disorders Unit of the San Raffaele Turro Hospital in Milan. The results of binary logistic regression analyses showed that previous SA and current suicide ideation play a role in predicting serious SA. Considering the DSM‐5 personality dysfunctional domains assessed by the Personality Inventory for DSM‐5, our logistic regression analyses suggested that high lethality SA was associated with Detachment PID‐5 domain. Finally, binary hierarchical regression analysis showed that Detachment domain remained a significant predictor of serious SA over and above the effect of previous SA and suicide ideation. As a whole, our results highlight the importance of a multidimensional approach to develop adequate assessment, effective treatments and prevention of high lethality SA risk.
Do tax policies discriminate against female traders? A gender framework to study informal marketplaces in Nigeria
Authors: Akpan Imaobong , Cascant‐Sempere Mª Josep 
Published: August 2022

AbstractScholars have long debated formalizing the informal sector through taxation, but how do these processes affect gender inequalities? Our study in Nigerian markets contributes a gender framework to the equitable taxation literature on formalization. The study draws on a survey of 451 traders in 12 markets, key informant interviews, and ethnographic research in four markets of two states. We find that in at least two situations taxation policies discriminated against women implicitly: (1) male tax collectors had higher incidences of harassment on all traders and (2) taxing traders with flat taxes penalized women, as they earned less than men but were taxed the same.
Atmospheric pressure plasma‐jet treatment of polyacrylonitrile‐nonwovens: Activation leading to high surface area carbon electrodes
Authors: Hoffmann Andreas , Uhl Matthias , Ceblin Maximilian , Bansmann Joachim , Jacob Timo , Kuehne Alexander J. C. 
Published: August 2022

AbstractCarbon nanofiber nonwovens (CFN) are powerful electrode materials with exceptional performance in energy storage devices, such as batteries and supercapacitors. Small fiber‐diameters together with hierarchical porosity endow CFN‐electrode materials with large surface areas and high electrical capacitance. Porosity of the fiber surface is often realized by corrosive activation methods such as wet‐etching or using oxidative gases at elevated temperatures. In this study, we present a chemical‐free, environmental‐friendly, and easily controllable surface activation method using an atmospheric pressure plasma‐jet. We investigate the best instant for activation along the process chain and show that the surface area of nanofiber nonwovens can be tailored by adjusting the plasma exposure‐dose. Plasma‐activated CFNs show an almost 20‐fold increase in capacitance (CspPJ = 10.1 F/g) in an electrochemical supercapacitor setup compared to nonactivated CFN (CspnoPJ = 0.55 F/g).
Data sharing for conservation: A standardized checklist of US native tree species and threat assessments to prioritize and coordinate action
Authors: Carrero Christina , Beckman Bruns Emily , Frances Anne , Jerome Diana , Knapp Wesley , Meyer Abby , Mims Ray , Pivorunas David , Speed DeQuantarius , Treher Eberly Amanda , Westwood Murphy 
Published: August 2022

Societal Impact StatementUnderstanding the current state of trees within the United States is imperative for protecting those species, their habitats, and the countless communities they support, as well as the ecosystem services they provide. We present an updated checklist of all tree species native to the contiguous United States, their state distribution, extinction risk, and most common threats. Knowledge of national threat “hotspots” and conservation priorities facilitates efficient conservation efforts and the allocation of resources to safeguard the 11–16% of US tree species that are threatened. These results lay the groundwork for tree and ecosystem conservation efforts in the United States that contribute to achieving critical international conservation goals, including the United Nations Decade for Ecosystem Restoration and the Global Tree Assessment.Summary

The Global Tree Assessment aims to complete threat assessments for all the world's ~60,000 tree species, but most species native to the continental United States had either never been assessed or were outdated on the two most widely used threat assessment platforms in the United States, International Union for the Conservation of Nature (IUCN) Red List and NatureServe. There was also no coordinated mechanism for sharing data between these platforms, resulting in missing, duplicated, or outdated information.
We (1) created an updated checklist of all tree species native to the contiguous United States based on the standardized Global Tree Assessment tree definition, (2) created over 700 new or updated IUCN Red List assessments and NatureServe Global Ranks, and (3) developed a replicable assessment data sharing process.
We present an updated checklist of native US trees that includes 881 species from 269 genera, with Quercus and Crataegus as the most species‐rich tree genera. We present the first country‐wide analysis of tree extinction risk, patterns of geographic and taxonomic diversity, and leading threats. An estimated 11–16% of US tree species are threatened with extinction, with the most common threat being invasive and problematic pests and diseases. We introduce a “crosswalk” process for efficient, large‐scale data sharing between the IUCN Red List and NatureServe, using IUCN Red List Species Information Service (SIS) Connect, which can be applied to other taxonomic groups in North America.
The checklist, threat assessments, and crosswalk methodology represent a significant advancement in prioritizing conservation action for at‐risk tree species and restoration of forests in the United States, supporting the global goals of the United Nations Decade for Ecosystem Restoration and the Global Tree Assessment effort.
Lung structure and function on MRI in preterm born school children with and without BPD: A feasibility study
Authors: Elders Bernadette B. L. J. , Tiddens Harm A. W. M. , Pijnenburg Mariëlle W. H. , Reiss Irwin K. M. , Wielopolski Piotr A. , Ciet Pierluigi 
Published: August 2022

AbstractBackground and ObjectiveThe most common respiratory complication of prematurity is bronchopulmonary dysplasia (BPD), leading to structural lung changes and impaired respiratory outcomes. However, also preterm children without BPD may show similar adverse respiratory outcomes. There is a need for a safe imaging modality for preterm children with and without BPD for disease severity assessment and risk stratification. Our objective was to develop a magnetic resonance imaging (MRI) protocol in preterm children with and without BPD at school age.MethodsNine healthy volunteers (median age 11.6 [range: 8.8–12.8] years), 11 preterm children with BPD (11.0 [7.2–15.6] years), and 9 without BPD (11.1 [10.7–12.6] years) underwent MRI. Images were scored on hypo‐ and hyperintense abnormalities, bronchopathy, and architectural distortion. MRI data were correlated to spirometry. Ventilation and perfusion defects were analyzed using Fourier Decomposition (FD) MRI.ResultsOn MRI, children with BPD had higher %diseased lung (9.1 (interquartile range [IQR] 5.9–11.6)%) compared to preterm children without BPD (3.4 (IQR 2.5–5.4)%, p < 0.001) and healthy volunteers (0.4 (IQR 0.1–0.8)%, p < 0.001). %Diseased lung correlated negatively with %predicted FEV1 (r = −0.40, p = 0.04), FEV1/FVC (r = −0.49, p = 0.009) and FEF75 (r = −0.63, p < 0.001). Ventilation and perfusion defects on FD sequence corresponded to hypointense regions on expiratory MRI.ConclusionChest MRI can identify structural and functional lung damage at school age in preterm children with and without BPD, showing a good correlation with spirometry. We propose MRI as a sensitive and safe imaging method (without ionizing radiation, contrast agents, or the use of anesthesia) for the long‐term follow‐up of preterm children.
Active site center redesign increases protein stability preserving catalysis in thioredoxin
Authors: Romero Maria Luisa , Garcia Seisdedos Hector , Ibarra‐Molero Beatriz 
Published: August 2022

AbstractThe stabilization of natural proteins is a long‐standing desired goal in protein engineering. Optimizing the hydrophobicity of the protein core often results in extensive stability enhancements. However, the presence of totally or partially buried catalytic charged residues, essential for protein function, has limited the applicability of this strategy. Here, focusing on the thioredoxin, we aimed to augment protein stability by removing buried charged residues in the active site without loss of catalytic activity. To this end, we performed a charged‐to‐hydrophobic substitution of a buried and functional group, resulting in a significant stability increase yet abolishing catalytic activity. Then, to simulate the catalytic role of the buried ionizable group, we designed a combinatorial library of variants targeting a set of seven surface residues adjacent to the active site. Notably, more than 50% of the library variants restored, to some extent, the catalytic activity. The combination of experimental study of 2% of the library with the prediction of the whole mutational space by partial least squares regression revealed that a single point mutation at the protein surface is sufficient to fully restore the catalytic activity without thermostability cost. As a result, we engineered one of the highest thermal stabilities reported for a protein with a natural occurring fold (137°C). Further, our hyperstable variant preserves the catalytic activity both in vitro and in vivo.
Baseline sensitivity and control efficacy of a new QiI fungicide, florylpicoxamid, against Botrytis cinerea
Authors: Li Xiong , Yang Jikun , Jiang Qinghong , Tang Lijun , Xue Ziwei , Wang Haihong , Zhao Deyou , Miao Jianqiang , Liu Xili 
Published: August 2022

AbstractBackgroundGray mold caused by Botrytis cinerea is an airborne plant pathogen with a necrotrophic lifestyle that infects more than 200 crops worldwide. Florylpicoxamid is a second‐generation picolinamide fungicide inspired by a natural product. Florylpicoxamid targets the Qi site of the mitochondrial cytochrome bc1 complex and is currently being registered in China for the control of gray mold in a variety of crops. Although a broad spectrum of activity and attributes have been reported for florylpicoxamid, little is known about its effectiveness against gray mold or its protective and curative properties.ResultsFlorylpicoxamid exhibited substantial inhibitory activity against 12 tested species of plant‐pathogenic fungi, with effective concentration for 50% growth inhibition (EC50) values ranging from 0.017 to 2.096 μg ml−1. A total of 129 isolates of B. cinerea from ten regions were tested for their sensitivity to florylpicoxamid, and the mean EC50 value was 0.04 ± 0.017 μg ml−1. Furthermore, florylpicoxamid was observed to substantially inhibit all developmental stages of B. cinerea, with mycelial development, sclerotium germination, germ tube elongation and conidial germination being restrained with an EC50 value of 0.051 ± 0.0072, 0.012 ± 0.0069, 0.019 ± 0.0041 and 0.0062 ± 0.0007 μg ml−1, respectively. No cross‐resistance was observed between florylpicoxamid and quinone outside inhibitor (QoI), methyl benzimidazole carbamates or succinate dehydrogenase inhibitor. Florylpicoxamid also exhibited protective and curative activity against the development of B. cinerea infection in tests on tomato fruits. At application rates of 90, 112.5 and 135 g a.i. ha−1, florylpicoxamid was also observed to provide more‐effective control than boscalid (300 g a.i. ha−1).ConclusionThis study demonstrated that the novel fungicide florylpicoxamid exhibits strong inhibitory activity against B. cinerea, regardless of the resistance profiles of those isolates to tested fungicides with different modes of action. This makes florylpicoxamid a powerful new solution to optimize gray mold control and manage fungicide resistance. © 2022 Society of Chemical Industry.
Housing characteristics and health in urban China: A comparative study of rural migrants and urban locals
Authors: Zhou Min , Guo Wei 
Published: August 2022

AbstractChina's internal migration has produced a massive population of rural‐to‐urban migrants who face more structural and policy disadvantages in cities, compared with urban locals. The two social groups potentially differ both in their housing characteristics and in the health effects of these housing characteristics. These two differences are fundamentally distinct components that make up the overall impact of housing on health disparity between urban locals and rural‐to‐urban migrants. Using the 2017 China Migrants Dynamic Survey data, this study explores the differing connections of housing characteristics and health between the two groups in today's urban China. Overall, housing type and size have greater effects on the health of migrants, whereas housing instability has a greater impact on the health of urban locals. We utilize the Blinder–Oaxaca decomposition method to uncover to what extent the disparity in health between the two groups is due to the difference in their housing characteristics or the difference in the health effect of housing characteristics. In so doing, this study reveals two interrelated but distinct sources of housing‐induced health disparity between urban locals and migrants in urban China.
Two‐ and three‐dimensional measurements following robotic‐assisted total knee arthroplasty
Authors: Hasegawa Masahiro , Tone Shine , Naito Yohei , Sudo Akihiro 
Published: August 2022

AbstractBackgroundThe purpose of this study was to compare component alignment using two‐dimensional (2D) and three‐dimensional (3D) measurements following total knee arthroplasty (TKA) with a new robotic system.MethodsA total of 38 patients underwent TKA with the robotic system. Cutting errors were measured. Errors in 2D and 3D component alignments from the planned angle, validated cutting angle, and validated implantation angle were calculated. These errors were compared with 2D and 3D measurements.ResultsCutting errors were below 0.6°, except for femoral sagittal angle (1.0°). Errors in component alignment from the planned and cutting angles were significantly higher in 3D measurements than that in 2D measurements, in the femoral coronal and sagittal planes and tibial coronal planes. Errors in component alignments from implantation showed no differences between the measurements.ConclusionThe accuracies of component alignment from the planned and cutting angles were better in 3D measurements.
Smart river management: What is next?
Authors: Gourbesville Philippe , Ma Qiang 
Published: August 2022

AbstractThe growing complexity of the competition among uses and the emerging understanding of the synergy effects within the catchments and the rivers have underlined the need for information on various aspects of water: precipitations, discharges, velocities, and water depths are some of the basic characteristics that need to be studied for developing a management strategy that can identify and balance the various uses, ensure conservation of resources, and mitigate the potential effect of extreme events. At present, technical innovation provides the possibility to perform measurements on the field, to produce the needed information, and to move to a new paradigm for the management of rivers. This study analyzes the concept of smart river management that emerged recently with the wide spread of Information Technologies (IT) solutions and development of a new generation of sensors based on internet of things architecture. The analysis demonstrates that a holistic approach is needed for efficient management of rivers. The use of Information and Communication Technologies solutions can provide a real added value, but important efforts must be engaged for identifying key activities in the various domains that can benefit from the digital transformation. At the same time, this study introduces the paradigm of a river information system that encompasses the various activities taking place around the rivers and ensures gradual integration of the various IT components in a consistent environment that provides support to the many users of rivers. To achieve this objective, the current situation requires formalization of a roadmap and the need to address the various activities in a systematic way. Within this long‐term process, the digital twins concept represents a step toward the target water information system and has generated interest among professional communities.
Financial inclusion and trade adjusted carbon emissions: Evaluating the role of environment related taxes employing non‐parametric panel methods
Authors: Xin Na , Xie Zhuoting 
Published: August 2022

AbstractTrade adjusted or consumption‐based carbon emissions relatively is a new area of research. Trade adjusted carbon emissions is adjusted by deducting exports, adding imports and production based carbon emissions. This measure enables to capture the importance or contribution of international trade to global carbon emissions. This study further highlights each country's contribution to global carbon emissions through trade. This study aims to explore the possible determinants of trade adjusted carbon emissions for group of seven economies from 2000–2020. This study used a novel index for financial inclusion along with the role of environment related taxes and environment related innovation is also tested. The study uses non parametric method of panel data, that is, method of moments quantile regression, along with panel cointegration and diagnostic tests to detect interdependence and heterogeneity in the slop. Moreover, this study also tested the role of exports and imports with GDP for trade adjusted carbon emissions. The empirical findings from this study suggest that exports, environment related innovation and taxes and financial inclusion cause a reduction in trade or consumption‐based carbon emissions. Moreover, both imports and gross domestic product cause an upsurge in consumption or trade adjusted carbon emissions. This study provides practical policy implications in the light of empirical findings related to environment related taxes, financial inclusion, exports, environment related innovations, imports and gross domestic product.
College students' momentary stress and prescription drug misuse in daily life: Testing direct links and the moderating roles of global stress and coping
Authors: Papp Lauren M. , Kouros Chrystyna D. , Armstrong Laurie , Curtin John J. 
Published: August 2022

AbstractPrior survey‐based research has documented associations between greater levels of stress and increased prescription drug misuse behaviour. These studies uniformly rely on assessments of both the stress experiences and the substance behaviour after they occurred (commonly spanning 6–12 month retrospective timeframes). Less is known about the extent to which variations in momentary stress predict the actual occurrence of prescription misuse in daily life among college students with elevated risk for engaging in the behaviour. In this study, 297 participants (69% females; Mage = 19.5 years, SDage = 0.71) completed a 28‐day ecological momentary assessment procedure that collected self‐reported stress and other contextual experiences in moments preceding prescription drug misuse. Analyses tested the within‐person association between momentary stress and prescription drug misuse and examined the extent to which the relation between stress and misuse was moderated by participants' assigned sex or global stress and coping levels. Results from hierarchical generalised linear modelling indicated a significant within‐person association between momentary stress (i.e., higher than usual relative to one's own mean) and greater likelihood of prescription misuse in daily life, accounting for the number of stressors and timing covariates. No significant moderation by participant sex was found, and moderation effects by global stress and coping levels were not in the expected directions. Direct results highlight the role of momentary stress experiences on health‐relevant substance behaviours and provide future directions for research and applied efforts.
pH‐Universal Catechol‐Amine Chemistry for Versatile Hyaluronic Acid Bioadhesives
Authors: An Soohwan , Jeon Eun Je , Han Seung Yeop , Jeon Jihoon , Lee Mi Jeong , Kim Sooyeon , Shin Mikyung , Cho Seung‐Woo 
Published: August 2022

AbstractCatechol, a major mussel‐inspired underwater adhesive moiety, has been used to develop functional adhesive hydrogels for biomedical applications. However, oxidative catechol chemistry for interpolymer crosslinking and adhesion is exclusively effective under alkaline conditions, with limited applications in non‐alkaline conditions. To overcome this limitation, pH‐universal catechol–amine chemistry to recapitulate naturally occurring biochemical events induced by pH variation in the mussel foot is suggested. Aldehyde moieties are introduced to hyaluronic acid (HA) by partial oxidation, which enables dual‐mode catechol tethering to the HA via both stable amide and reactive secondary amine bonds. Because of the presence of additional reactive amine groups, the resultant aldehyde‐modified HA conjugated with catechol (AH‐CA) is effectively crosslinked in acidic and neutral pH conditions. The AH‐CA hydrogel exhibits not only fast gelation via active crosslinking regardless of pH conditions, but also strong adhesion and excellent biocompatibility. The hydrogel enables rapid and robust wound sealing and hemostasis in neutral and alkaline conditions. The hydrogel also mediates effective therapeutic stem cell and drug delivery even in dynamic and harsh environments, such as a motile heart and acidic stomach. Therefore, the AH‐CA hydrogel can serve as a versatile biomaterial in a wide range of pH conditions in vivo.