bluuebunny/crossref_metadata_2025_split huggingface dataset:
The recent status of synthetic dyes mycoremediation: A review
Authors: Melati I , Rahayu G , Henny C 
Published: July 2022

AbstractSynthetic dyes are extensively utilized in various industries like food and beverage, medicine, cosmetics, dyeing, leather, and textiles, so these dyes are frequently found within the effluent of those industrial wastes. Disposal of coloured waste from various industries into rivers and lakes will reduce dissolved oxygen concentration and produce poisonous conditions in aquatic ecosystems. Additionally, synthetic dye will produce tough composites to degrade (recalcitrant), which can beget carcinogenic, mutagenic, and antipathetic goods on the mortal body. Colour disposal of the synthetic dye before being discharged into the environment is necessary. A provident and environmentally friendly dye removal technology is needed. One similar technology is mycoremediation. Mycoremediation is fungus-based remediation technology that was quite promising in decolorizing synthetic dyes. Various fungi, either directly or by their enzymes, free or immobilized cells have been widely used as dye bioremediation agents. A few investigate works have been exhausted this region, and numerous are going on by researchers to discover the proficient way for such bioremediation. In this review, we describe the most updated research (2019-2021) on fungi as synthetic dye bioremediation agents. However, further evaluation is needed to look at the toxicity of the dye degradation products, the potential utilization of fungal biomass used in the mycoremediation process, and economic value analysis to ensure the development of green technologies.
Performance of natural coagulant extracted from tapioca and corn flour for the treatment of tofu wastewater
Authors: Prihatinningtyas E , Effendi A J 
Published: July 2022

Abstract
Present study investigates the ability of tapioca and corn flour for turbidity, total suspended solids (TSS) and chemical oxygen demand (COD) removal from tofu wastewater. The active coagulant agent were succesfully extracted from tapioca and corn flour using NaCl (namely tapioca and corn extract) and Amberlite resin (namely tapioca ionic and corn ionic). Experiment were conducted in batch mode for initial turbidity of 527 NTU, initial TSS 740 mg/L and initial COD 13,015.04 mg/L. Results demonstrated that tapioca extract is less efficient in turbidity, TSS and COD removal compare to corn extract. Corn extract was found to provide high turbidity removal with efficiency of 71% and TSS removal with efficiency of 35%. Meanwhile, corn ionic was reported have the highest ability in COD removal and reached 31.71% efficiency. Thus, the natural coagulants extracted from NaCl and Amberlite resin revealed to be effective only for turbidity removal.
Evaluating Inflow Result from SWAT Model at Singkarak Lake Under Limited Data
Authors: Wibowo H , Ridwansyah I , Rahmat A 
Published: July 2022

Abstract
Sustained lake functioning requires proper management in the catchment area and the water body. To address this, information on lake water balance is crucial because it is the basis for many scientific investigations of processes that occur in lake ecosystems. In many lakes, inflow from catchment areas is dominated by river flow. The problem is that inflow measurement data on rivers into the lake are difficult to obtain. Several models are used for inflow estimation, but validation will undoubtedly be complex because there is no observational data. The approach taken is to analyze the model results’ inflow accuracy through water balance analysis based on observational data on water level, climatology, and outflow. This approach will be implemented on Singkarak Lake, 109.08 km2, which is a tectonic lake located in West Sumatra. The method used to calculate inflow uses the SWAT hydrological model based on land use data in 2014 and Chirps rainfall in the 2010-2019 period. Water balance analysis is used to evaluate the inflow of the model results based on observational data on water level and outflow. The results show that the monthly inflow is too high, with an average excess of 6.21cms, which causes the average water level to be 0.52 meters higher.
Peatland Management Based on Hydrological Characteristics at Peatland Rangsang Island, Kepulauan Meranti Regency
Authors: Turmudi  , Fahrudin Muh. 
Published: July 2022

Abstract
Rangsang Island is one of the three main islands in the Kepulauan Meranti district which is dominated by peatlands. Rangsang Island, which faces the Straits of Malacca in the east, is under massive pressure in the utilization of its land. In the management of peatlands, the hydrological aspect plays an important role, in accordance with the characteristics of peatlands where the land is saturated with water, either periodically or permanently. This study aims to determine the hydrological characteristics of peatlands in an effort to sustainably manage peatlands in the Rangsang Island area. The method used is spatial analysis, hydrological analysis of peatlands. The data used consists of land unit maps, soil maps, rainfall for the period 1998-2019, ground water level (GWL) period August 2019-August 2021 population data. The results of this study indicate that fluctuations of GWL during dry season were 42 – 45 cm relatively safe; and GWL control in peatland management is very important in dealing sustainability of peat land especially during dry season. Cultivation of plants that are adaptive to the peat ecosystem such as liberica coffee supports an efforts to sustain the peatland area.
Self-supplied water in Indonesia: recent spatial and socio-demographic conditions and its future development
Authors: Cahyadi R , Kusumaningrum D , Prasetyoputra P 
Published: July 2022

Abstract
Indonesia is currently on track in achieving the Sustainable Development Goal (SDG) Goal 6. In clean water provision, many regions, especially urban areas, are facilitated by both state-owned and private-owned water utility companies. However, the coverage of these public and private clean water providers is still limited. Many households in areas not covered with formal clean water provisions secure their needs with self-supplied clean water provisions. Many works of literature show that self-supplied clean water can be an alternative to the unequal, slow and even failed public provision of water services. However, there has been little research in Indonesia that attempts to examine the current self-supplied water managed by communities. Thus, this paper explores the provision of self-supplied water at the household level using the 2018 SUSENAS data. This paper will develop two categories of households based on the source of clean water both in rural and urban areas and explore several other categories (based on administrative and geographical characteristics). The purpose of this research is to show the potential of self-supplied water in various regions in Indonesia to support the government’s strategy and progress in achieving universal access to clean water by 2030.
Development of a vascular substitute produced by weaving yarn made from human amniotic membrane
Authors: Grémare Agathe , Thibes Lisa , Gluais Maude , Torres Yoann , Potart Diane , Da Silva Nicolas , Dusserre Nathalie , Fénelon Mathilde , Sentilhes Loïc , Lacomme Sabrina , Svahn Isabelle , Gontier Etienne , Fricain Jean-Christophe , L’Heureux Nicolas 
Published: July 2022

Abstract
Because synthetic vascular prostheses perform poorly in small-diameter revascularization, biological vascular substitutes are being developed as an alternative. Although their in vivo results are promising, their production involves long, complex, and expensive tissue engineering methods. To overcome these limitations, we propose an innovative approach that combines the human amniotic membrane (HAM), which is a widely available and cost-effective biological raw material, with a rapid and robust textile-inspired assembly strategy. Fetal membranes were collected after cesarean deliveries at term. Once isolated by dissection, HAM sheets were cut into ribbons that could be further processed by twisting into threads. Characterization of the HAM yarns (both ribbons and threads) showed that their physical and mechanical properties could be easily tuned. Since our clinical strategy will be to provide an off-the-shelf allogeneic implant, we studied the effects of decellularization and/or gamma sterilization on the histological, mechanical, and biological properties of HAM ribbons. Gamma irradiation of hydrated HAMs, with or without decellularization, did not interfere with the ability of the matrix to support endothelium formation in vitro. Finally, our HAM-based, woven tissue-engineered vascular grafts (TEVGs) exhibited clinically relevant mechanical properties. Thus, this study demonstrates that human, completely biological, allogeneic, small-diameter TEVGs can be produced from HAM, thereby avoiding costly cell culture and bioreactors.
Low temperature hybrid 3D printing of hierarchically porous bone tissue engineering scaffolds with in situ delivery of osteogenic peptide and mesenchymal stem cells
Authors: Lai Jiahui , Wang Chong , Liu Jia , Chen Shangsi , Liu Chaoyu , Huang Xiangxuan , Wu Jing , Pan Yue , Xie Yuancai , Wang Min 
Published: July 2022

Abstract
Compared to other conventional scaffold fabrication techniques, three-dimensional (3D) printing is advantageous in producing bone tissue engineering scaffolds with customized shape, tailored pore size/porosity, required mechanical properties and even desirable biomolecule delivery capability. However, for scaffolds with a large volume, it is highly difficult to get seeded cells to migrate to the central region of the scaffolds, resulting in an inhomogeneous cell distribution and therefore lowering the bone forming ability. To overcome this major obstacle, in this study, cell-laden bone tissue engineering scaffolds consisting of osteogenic peptide (OP) loaded β-tricalcium phosphate (TCP)/poly(lactic-co-glycolic acid) (PLGA) (OP/TCP/PLGA, designated as OTP) nanocomposite struts and rat bone marrow derived mesenchymal stem cell (rBMSC)-laden gelatin/GelMA hydrogel rods were produced through ‘dual-nozzle’ low temperature hybrid 3D printing. The cell-laden scaffolds exhibited a bi-phasic structure and had a mechanical modulus of about 19.6 MPa, which was similar to that of human cancellous bone. OP can be released from the hybrid scaffolds in a sustained manner and achieved a cumulative release level of about 78% after 24 d. rBMSCs encapsulated in the hydrogel rods exhibited a cell viability of about 87.4% right after low temperature hybrid 3D printing and could be released from the hydrogel rods to achieve cell anchorage on the surface of adjacent OTP struts. The OP released from OTP struts enhanced rBMSCs proliferation. Compared to rBMSC-laden hybrid scaffolds without OP incorporation, the rBMSC-laden hybrid scaffolds incorporated with OP significantly up-regulated osteogenic differentiation of rBMSCs by showing a higher level of alkaline phosphatase expression and calcium deposition. This ‘proof-of-concept’ study has provided a facile method to form cell-laden bone tissue engineering scaffolds with not only required mechanical strength, biomimetic structure and sustained biomolecule release profile but also excellent cell delivery capability with uniform cell distribution, which can improve the bone forming ability in the body.
Strong light-matter interactions in hybrid nanostructures with transition metal dichalcogenides
Authors: Xie Peng , Wu Yuyang , Li Yuhang , Chang Peijie , Zhang Hong , Wang Wei 
Published: July 2022

Abstract
The interaction between quantum emitters and photons in the strong coupling regime has received much attention in recent years due to its important position in fundamental and applied physics. Transition metal dichalcogenides (TMDs) have become ideal candidates for the study of strong light-matter interactions due to the formation of in-plane excitons exhibiting giant oscillator strength with narrow-band, well-pronounced optical transitions, which can be readily coupled to various optical excitations. The study of TMD-based strong coupling are leading to striking discoveries in many applications such as polariton condensation, lasing, all-optical switches and quantum information processing. This review summarizes the recent advances in strong coupling of TMD excitons with different types of nanostructures including traditional optical cavities, plasmonic nanocavities and all-dielectric nanoresonators. We finally discuss the future perspectives and possible directions on the TMD-based strong exciton–photon interactions in strong coupling regime.
Area-dependent gain and noise characteristics of mid-wavelength infrared HgCdTe planar electron avalanche photodiodes
Authors: Yang Dan , Guo Huijun , Zhu Liqi , Yang Liao , Chen Lu , Lin Chun , Ding Ruijun , He Li 
Published: July 2022

Abstract
This paper mainly investigates the area-dependent gain and noise characteristics of mid-wavelength infrared (MWIR) Hg0.7Cd0.3Te planarelectron avalanche photodiodes (e-APDs) operated at 80 K. The 10-μm-radius diode exhibits low dark current in the magnitude of 10–13 A below −5.5 V, high gain up to 1270 at −10 V, and low excess noise factor between 1 and 1.2. The optimal performances are compromised by tunneling current, which should be further suppressed. Studies on variable-area diodes show that larger diodes have a reduced gain due to a smaller contribution from edge gain, as well as an increased 1/f noise and corner frequency due to higher defect density. From the gain and noise perspectives, HgCdTe e-APDs with smaller junction areas are more suitable for focal plane array (FPA) applications.
Fast multi-qubit global-entangling gates without individual addressing of trapped ions
Authors: Wang Kaizhao , Yu Jing-Fan , Wang Pengfei , Luan Chunyang , Zhang Jing-Ning , Kim Kihwan 
Published: July 2022

Abstract
We propose and study ways speeding up of the entangling operations in the trapped ions system with high fidelity. First, we find a scheme to increase the speed of a two-qubit gate without the limitation of trap frequency, which was considered as the fundamental limit. Second, we study the fast gate scheme for entangling more than two qubits simultaneously. We apply the method of applying multiple frequency components on laser beams for the gate operations. In particular, in order to avoid infinite terms from the coupling to carrier transition, we focus on the phase-insensitive gate scheme here. We carefully study the effect of large excitation of motional mode beyond the limit of Lamb–Dicke approximation by including up to second order terms of the Lamb–Dicke parameter. We study the speed limit of multi-qubit global entangling gates without individual addressing requirements. Furthermore, our gates can be made insensitive to the fluctuation of initial motional phases which are difficult to stabilise in the phase-insensitive gate scheme.
Mapping properties of operator-valued Bergman projections
Authors: Wang Liang , Xu Bang , Zhou Dejian 
Published: July 2022

In this paper, we study the boundedness theory for Bergman projection in the operator-valued setting. More precisely, let

D

\mathbb {D}

be the open unit disk in the complex plane

C

\mathbb {C}

and

M

\mathcal {M}

be a semifinite von Neumann algebra. We prove that

‖
P
(
f
)

‖

L

1
,
∞

(

N

)

≤
C
‖
f

‖

L
1

(

N

)

,

\begin{equation*} \|P(f)\|_{L_{1,\infty }(\mathcal {N})}\leq C \|f\|_{L_1(\mathcal {N})}, \end{equation*}

where

N

=

L

∞

(

D

)

⊗
¯

M

\mathcal {N}=L_{\infty }(\mathbb {D})\bar {\otimes }\mathcal {M}

and

P
P

denotes the Bergman projection. Consequently,

P
P

is bounded on

L

p

(

N

)

L_{p}(\mathcal {N})

with

1
>
p
>
∞

1>p>\infty

. As applications, we also obtain Kolmogorov and Zygmund inequalities for the Bergman projection

P
P

.
Cabotegravir: The first long-acting injectable for HIV pre-exposure prophylaxis
Authors: Prather Caitlin , Jeon Chaeok 
Published: July 2022

Abstract

Purpose
The purpose of this article is to review the pharmacology, efficacy, and safety of the integrase inhibitor cabotegravir for HIV pre-exposure prophylaxis, including data from clinical trials.

Summary
A narrative review was performed by searching PubMed/MEDLINE databases to identify relevant articles published between March 2014 and December 2021 using the keyword terms cabotegravir and Apretude and the search strings “long-acting injectable AND human immunodeficiency virus” and “pre-exposure prophylaxis AND human immunodeficiency virus.” All relevant English-language articles evaluating the pharmacology, efficacy, or safety of cabotegravir in humans for HIV pre-exposure prophylaxis were included. Additional data were obtained from prescribing information, references of identified articles, and abstracts from scientific meetings. Cabotegravir has been approved by the Food and Drug Administration and is considered both safe and effective for HIV pre-exposure prophylaxis. It is the first long-acting injectable medication approved for this indication. Phase 3 clinical trials have demonstrated the noninferiority of cabotegravir to currently recommended oral once-daily dosing regimens. Injection-site reactions were common in clinical trials of cabotegravir and occurred in up to 81% of trial participants. Costs associated with the long-acting injectable formulation must also be considered.

Conclusion
Cabotegravir is a novel bimonthly, injectable option for pre-exposure HIV prophylaxis for high-risk adolescents and adults weighing at least 35 kg.
A Randomized, Placebo-Controlled Trial Evaluating the Single and Combined Efficacy of Radiofrequency and Hybrid Fractional Laser for Nonsurgical Aesthetic Genital Procedures in Post-Menopausal Women
Authors: Wamsley Christine , Kislevitz Mikaela , Vingan Nicole R , Oesch Sydney , Lu Karen , Barillas Jennifer , Hoopman John , Akgul Yucel , Basci Deniz , Kho Kimberly , Zimmern Phillipe E , Kenkel Jeffrey M 
Published: July 2022

Abstract

Background
The efficacy of interventions that provide long-term relief of genitourinary symptoms of menopause has not been determined.

Objectives
The authors sought to evaluate radiofrequency and hybrid fractional laser (HFL) treatments for menopausal vulvovaginal symptoms.

Methods
Thirty-one postmenopausal women completed all treatments and at least 1 follow-up. Outcomes included the Vulvovaginal Symptom Questionnaire (VSQ), Vaginal Laxity Questionnaire (VLQ), Urogenital Distress Short Form, Incontinence Impact Questionnaire (IIQ), Female Sexual Function Index (FSFI), laxity measurements via a vaginal biometric analyzer probe, and gene expression studies.

Results
Mean VSQ score decreased 2.93 (P = 0.0162), 4.07 (P = 0.0035), and 4.78 (P = 0.0089) among placebo, dual, and HFL groups 3 months posttreatment and decreased to 3.3 (P = 0.0215) for dual patients at 6 months. FSFI scores increased in the desire domain for placebo and dual groups and in arousal, lubrication, orgasm, satisfaction, and pain domains for the HFL group 3 and 6 months posttreatment. An increase of 1.14 in VLQ score (P = 0.0294) was noted 3 months and 2.2 (P = 0.002) 6 months following dual treatment. There was also a mean decrease of 15.3 (P = 0.0069) in IIQ score for HFL patients at 3 months. Dual, HFL, and RF treatments resulted in statistically significant decreases in collagen I, elastin, and lysyl oxidase expression.

Conclusions
Several self-reported improvements were noted, particularly among HFL, dual, and placebo groups 3 and 6 months posttreatment. Objective biopsy analysis illustrated decreased gene expression, suggesting that treatments did not stimulate new extracellular matrix production.

Level of Evidence: 2
Multifunctional chitosan/gelatin@tannic acid cryogels decorated within situreduced silver nanoparticles for wound healing
Authors: Xu Na , Yuan Yucheng , Ding Liangping , Li Jiangfeng , Jia Jiezhi , Li Zheng , He Dengfeng , Yu Yunlong 
Published: July 2022

AbstractBackgroundMost traditional wound dressings only partially meet the needs of wound healing because of their single function. Patients usually suffer from the increasing cost of treatment and pain resulting from the frequent changing of wound dressings. Herein, we have developed a mutifunctional cryogel to promote bacterial infected wound healing based on a biocompatible polysaccharide.MethodsThe multifunctional cryogel is made up of a compositive scaffold of chitosan (CS), gelatin (Gel) and tannic acid (TA) and in situ formed silver nanoparticles (Ag NPs). A liver bleeding rat model was used to evaluate the dynamic hemostasis performance of the various cryogels. In order to evaluate the antibacterial properties of the prepared cryogels, gram-positive bacterium Staphylococcus aureus (S. aureus) and gram-negative bacterium Escherichia coli (E. coli) were cultured with the cryogels for 12 h. Meanwhile, S. aureus was introduced to cause bacterial infection in vivo. After treatment for 2 days, the exudates from wound sites were dipped for bacterial colony culture. Subsequently, the anti-inflammatory effect of the various cryogels was evaluated by western blotting and enzyme-linked immunosorbent assay. Finally, full-thickness skin defect models on the back of SD rats were established to assess the wound healing performances of the cryogels.ResultsDue to its porous structure, the multifunctional cryogel showed fast liver hemostasis. The introduced Ag NPs endowed the cryogel with an antibacterial efficiency of &gt;99.9% against both S. aureus and E. coli. Benefited from the polyphenol groups of TA, the cryogel could inhibit nuclear factor-κB nuclear translocation and down-regulate inflammatory cytokines for an anti-inflammatory effect. Meanwhile, excessive reactive oxygen species could also be scavenged effectively. Despite the presence of Ag NPs, the cryogel did not show cytotoxicity and hemolysis. Moreover, in vivo experiments demonstrated that the biocompatible cryogel displayed effective bacterial disinfection and accelerated wound healing.ConclusionsThe multifunctional cryogel, with fast hemostasis, antibacterial and anti-inflammation properties and the ability to promote cell proliferation could be widely applied as a wound dressing for bacterial infected wound healing.
Immune responses to SARS-CoV-2 in dialysis and kidney transplantation
Authors: Cantarelli Chiara , Angeletti Andrea , Perin Laura , Russo Luis Sanchez , Sabiu Gianmarco , Podestà Manuel Alfredo , Cravedi Paolo 
Published: July 2022

ABSTRACT
Despite progressive improvements in the management of patients with coronavirus disease 2019 (COVID-19), individuals with end-stage kidney disease (ESKD) are still at high risk of infection-related complications. Although the risk of infection in these patients is comparable to that of the general population, their lower rate of response to vaccination is a matter of concern. When prevention strategies fail, infection is often severe. Comorbidities affecting patients on maintenance dialysis and kidney transplant recipients clearly account for the increased risk of severe COVID-19, while the role of uremia and chronic immunosuppression is less clear. Immune monitoring studies have identified differences in the innate and adaptive immune response against the virus that could contribute to the increased disease severity. In particular, individuals on dialysis show signs of T cell exhaustion that may impair antiviral response. Similar to kidney transplant recipients, antibody production in these patients occurs, but with delayed kinetics compared with the general population, leaving them more exposed to viral expansion during the early phases of infection. Overall, unique features of the immune response during COVID-19 in individuals with ESKD may occur with severe comorbidities affecting these individuals in explaining their poor outcomes.