bluuebunny/crossref_metadata_2025_split huggingface dataset:
On possibility of application of instrumental and projection assessment of pain syndrome
Authors: Morozov A. M. , Sorokovikova T. V. , Pichugova A. N. , Belyak M. A. 
Published: April 2022

Topicality. In modern medical practice, the issue of studying and developing methods for assessing pain syndrome is acute, which is associated not only with the complexity of interpreting this sensation, but also with the lack of a unified idea of the mechanism for forming pain sensations. The development of diagnostic capabilities in the field of medical practice and the possibility of widespread use of modern equipment allowed us to take a new look at the possibility of instrumental and projection assessment of pain syndrome.The purpose of this study is to study the possibility of using instrumental and projection assessment of pain syndrome in medical practice.Material and methods. The study was carried out on the basis of a compilation of data from modern domestic and foreign scientific sources in the field of the possibility of using instrumental and projection assessment of pain syndrome.Results. The latest methods of assessing pain syndrome are aimed at the maximum possible objectification of pain sensations, which allows making the most reliable clinical assessment of the patient's condition. Currently, research methods such as neuroimaging, determination of cutaneous electroconductivity, analgesic nociceptive index, surgical plethysmographic index, electroencephalography, plethysmography are being actively introduced. The instrumental methods described above are the latest methods for objectively assessing not only the intensity of pain syndrome, but also the degree of nociceptive protection when applying intraoperative analgesia methods. The ambiguity of the results obtained during clinical trials as part of the evaluation of the validity of these criteria for assessing the strength of nociception dictates the need to continue further research in the field of this issue.Conclusion. In modern medical practice, the issue of developing methods to ensure an adequate, objective assessment of the intensity of pain syndrome remains acute. This issue mainly concerns surgical doctors, which is associated with the need to provide an adequate anesthesiological allowance in the intraoperative period, which will avoid the development of postoperative pain syndrome. Solving this problem will contribute to a significant improvement in the results of therapeutic interventions and reduce the risk of developing chronic pain in the patient.
Effect Ultrafiltration Rate On Blood Pressure Chronic Kidney Disease Patient During Hemodyalisis: A Literature Review
Authors: Nuriya Nuriya , Taufik Agis 
Published: April 2022

Introduction: Data from the Kidney Foundation Diatrans Indonesia stated that the number of patients with renal failure in Indonesia is estimated to increase 4,400 patients each year. One of the adverse effects of chronic kidney disease is the disorder of blood filtration. Interventions applicable to patients with impaired filtration include hemodialysis therapy. Complications that often occur in patients undergoing hemodialysis are hemodynamic disorders, especially blood pressure to drop or intradialytic hypotension. Objective: This study aims to review some literature on the effect of ultrafiltration rate on blood pressure of patients with chronic kidney disease who undergo hemodialysis. Method: Journal article search is done electronically using multiple databases: PubMed database, Google Scholar, Science Direct and Mendeley from January 2007 to November 2017. Keywords used were "Ultrafiltration / Ultrafiltration rate", "Blood Pressure", "intradialytic intradialytic / intradialytic hypertension", "Hemodialysis", "Chronic Kidney Disease / CKD" to obtain three articles for review. Result: Ultrafiltration rate can be expressed as having an effect on blood pressure in a hemodialysis patient. Discussion: When hemodialysis, ultrafiltration is done to attract excess fluid in the blood. The amount of fluid secreted during hemodialysis can affect the drop in blood pressure due to a decrease in the volume of blood being pumped. This is related to the reduced volume of strokes produced by the heart. Conclusions: Ultrafiltration rate affects the blood pressure of patients undergoing hemodialysis.
Terapi Audio dengan Murottal Alquran Terhadap Perilaku Anak Autis: Literature Review
Authors: Anam Akhyarul , Khasanah Uswatun , Isworo Atyanti 
Published: April 2022

Introduction. Child auitism has a disorder in behavior, communication, social interaction and unstable emotions. Austism is a syndrome that results from complex muscle damage and neurodevelopmental disorders. Intervention to the behavior of children with autism can be done by providing murottal audio therapy Alquran.Objective. this study aimed to examine the effect of audio therapy with murottal Alquran on the behavior of austistic children.Methods. Article searches conducted electronically using several databases: Proquest, PubMed, Mendeley, and Google Scholar since 2013-2017. Keywords used are "audio therapy / audio therapy", "Alquran", behavioral disorders”, " autism / autism "; so get 3 articles to be reviewed.Results. Audio therapy with murottal Alquran can decrease autistic child's behavior disorder both in emotion, communication and social interaction compared with music therapy.Discussion. Provision of murottal Alquran therapy provides a positive effect for autistic children to reduce behavioral disorders, murottal therapy Alquran can be done for other disease interventions because this therapy does not cause side effects and safe.Conclusion. Audio therapy with murottal Alquran can decrease autistic child behavior.
Efektifitas Terapi Akupresur terhadap Frekuensi Enuresis pada Anak dengan Syndrom Down
Authors: Wahyudi Wahyudi , Handoyo Handoyo , Sumedi Taat 
Published: April 2022

Down Syndrome (DS) or Mongoloid is a condition in which extra genetic material causes delays in the development of children, and sometimes refers to mental retardation. One of disturbance that commonly appear form children who has down syndrome is enuresis (bedwetting). One of therapy that is believed has an effect of enuresis frequency is acupressure.The objective of this study was to determine the effectiveness of acupressure on the frequency of enuresis in children with Down syndrome. This research uses a pre- experimental design approaching Non - randomized pretest - Posttest Design. This study was 30 down Syndrome children suffering enuresis in disability elementary school (Sekolah Dasar Luar Biasa) Kuncup Mas Banyumas. Sampel was taken by total sampling method. Statistical analysis test used is the paired t test and ANOVAThe results show there is significant differences of acupressure towards frekwensi enuresis of Down syndrome children suffering enuresis with p value at 0.000. In Indonesia, an estimated number of infants up to 30% of the 250 million population of Indonesia, and according to the Household Health Survey (Survey) is estimated to number of infants who already control defecation and urination in the preschool years to reach 75 million children. Nevertheless, there are still about 30% of children aged 4 years and 10% of children aged 6 years who are still afraid to go to the bathroom let alone at night. According to the Child Development Institute Toilet training at the American Psychiatric Association study reported that 10 -20% of children aged 5 years, 5% of children aged 10 years, nearly 2% of children aged 12-14 years, and 1% of children aged 18 years still wet (Medicastore, 2008).
Penurunan Toksisitas Kadmium Dengan Kelator Alami Pegagan (Centella Asiatica) Ditinjau dari Kadar Malondialdehid (MDA) dan Superoksida Dismutase (SOD)
Authors: Hernayanti Hernayanti , Lestari Sri 
Published: April 2022

Cadmium (Cd) is a heavy metal that is toxic to humans. Cadmium will bind to metalotionin in the liver to form Cd+MT bonds, which triggers the formation of free radicals and causes oxidative stress. Oxidative stress characterized by elevating of MDA and decreasing of antioxidant enzyme such as SOD. Gotu kola(Centella asiatica) contains active compounds medecassoside that can function to chelate Cd, decreasing MDA level caused by Cd-Mt bounded and generate SOD level.The aim of this study is to know the effect of Pegagan as natural chelator for Cd poisoning and as antioxidant. Twenty four rats were used in this research and divided into six groups with four replications. Group 1 (C1) as healthy. Group 2 (C2) was only given 14 mg/200 gBW of CdSO4 for 35 days. Group 3, 4, 5 and 6 were given CdSO4 14 mg / 200kgBB and gotu kola extract dose of 20 mg/200gBB, 40 mg/200gBB, 60 mg/200gBB, 80 mg / 200gBB, for 21 days. The parameters studied were blood MDA and SOD level. Measuring parameters were done on the 36th day after administration of Centella extract. Data were analyzed by Anova and followed by Duncan test The results showed that Centella all doses can reduce MDA level and increase SOD level. A dose of 40mg / 200gBB Centella extract has been effective in reducing MDA level as well as increasing SOD level. It can be concluded that dose of 40mg/200gBB can use as a natural chelator of Cd and as antioxidant for Cd poisoning.
Gambaran Kesiapan Mahasiswa Tingkat Akhir dalam Menghadapi Profesi Ners di Universitas Jenderal Soedirman Saat Pandemi Covid-19
Authors: Fajrin Ramadhani Laela , Rahayu Eva , Imam Hidayat Arif 
Published: April 2022

Background. Covid-19 pandemic has an affect on changing the learning methods of Nurse Internship Program at Jenderal Soedirman University. The Nurse Internship Program is carried out by limiting students who practice in hospitals or clinics and combining learning online and offline. With these changes, it may affect student’s readiness to continue nurse profession.
Methods. This study used quantitative research design. Sampling using total sampling technique with 90 people as sample from class 2016 and class 2017. Data analysis used univariate test.
Results. The majority of respondent have a good level of readiness (60,0%). Most of the respondent were 21 years old. The majority of responden were women as many as 80 people (88,9%). And most of the respondent came from class 2017 as many as 76 people (84,4%). From age range of respondents, 21 years old have a better readiness (64,3%) than other ages. Respondent with male gender have better readiness (70,0%) than women (58,8%). Class 2016 has better readiness than class 2017 (59,2%).
Conclusion. The majority of the respondents have a good readiness category (60,0%).
Description of Student Learning Motivation to Online Practices
Authors: Maulana Yuliar , Adi Mulyono Wastu , Sumeru Anas 
Published: April 2022

Background: The pandemic makes online learning methods the right choice so that the learning process can continue. The learning methods in universities generally consist of the lecture/lecturer method and the skill lab method. The online practicum method is packaged in audio-visual form but has the disadvantage that the opportunity for red-demonstration cannot be carried out optimally due to limited tools and materials as well as supporting facilities. This is one of the factors that can affect student learning motivation to decrease.
Methods: This study used a retrospective descriptive research design. The population to be studied is the students of the Department of Nursing at Jenderal Soedirman University using the Stratified Random Sampling technique and obtained 183 respondents. This study uses a questionnaire regarding the ARCS-V Motivation model (Keller 2016) which has been modified. Data analysis to be carried out is univariate analysis.
Results: The results of the study that students' learning motivation towards online learning was included in the low category, quite a lot, namely there were 27 students (14.75%). 133 students (72.68%) with moderate learning motivation and 23 students (12.57%) with high learning motivation.
Conclusion: The results showed that students' learning motivation towards online learning was included in the medium-high category range. This shows that online practicum can increase learning motivation. Online practicum is a solution for practical learning methods in the COVID-19 pandemic situation.
Guided Imagery And Progressive Muscle Relaxation In Cancer Patients Undergoing Chemotherapy : A Literature Review
Authors: Taufik Agis , Nuriya  
Published: April 2022

ABSTRACT
Introduction: Cancer is one of the health problems with a rapid increase in incidence and proven to be the second leading cause of death in the world today. Cancer is also a common problem that occurs in the elderly who suffer from the predicted increase in 605 million in 2000 to 2 trillion in 2050 (Shahriari et al., 2017). Therapy that is often done by patients is by doing chemotherapy, but by doing chemotherapy there are many side effects on the patient's physical and psychological. Interventions that can be given in addition to pharmacological drugs are alternative or complementary therapies. Independent intervention that can be done by nurses in patients given Progressive Muscle Relaxation (PMR) therapy and guided images (GI). Method: Search is done electronically using a database, including google scholer and sch from May 2019 to June 2019. The keywords used are "Therapy for Cancer Patients", "Guided Images & Progressive Muscle Relaxation in Cancer Patients" and "Progressive Muscles Relaxation" . Search uses the keywords above with the Google Scholer and Sci-Hub databases. Search results on Google Sholer and Sci-Hub obtained several articles. Results: Independent nursing interventions such as Progressive Muscle Relaxation (PMR) can be used in all stages of cancer and are known to reduce complications from cancer treatment (Shahriari et al., 2017). GI is a complementary therapy that can be applied under different conditions and at various participations to improve quality of life and decrease the risk of cancer (Shahriari et al., 2017). Discussion: GI and PMR interventions show strong evidence of the benefits of managing cluster considerations in prostate and breast cancer patients. In the intervention group compared with controls. Conclusion: PMR and GI interventions that address cancer patients who support Chemotherapy.
Variations in the Adaptive Response of <i>Burkholderia pseudomallei</i> to Cold Stress
Authors: Zakharova I. B. , Chirskov P. R. , Ustinov D. V. , Viktorov A. D. , Shpak I. M. , Toporkov А. V. , Viktorov D. V. 
Published: April 2022

The aim of the study was to analyze differential gene expression in Burkholderia pseudomallei strains with different survival rates under cold stress conditions.Materials and methods. Three strains of B. pseudomallei (sequence types ST 46, ST 70, and ST 85) were used as model strains. The RNA was isolated using the membrane columns method and stabilized through dehydration. The cDNA was sequenced on the Illumina MiSeq platform. Gene functions were classified using the KEGG PATHWAY database.Results and discussion. Based on the analysis of transcriptomes of B. pseudomallei strains after prolonged exposure to cold stress, the molecular mechanisms of B. pseudomallei adaptation to low temperatures have been described for the first time ever. It was shown that adaptation of B. pseudomallei to cold stress is associated with regulatory processes leading to a significant decrease in the total transcriptional activity. Two strategies of adaptation to low temperatures have been found: 1) modulation of regulatory processes leading to suppression of gene expression of the main metabolic pathways to the minimum level that ensures cell viability and activation of the minimum required set of stress response genes, and 2) less noticeable suppression of general metabolism in combination with activation of expression of an extended range of genes for cold and heat shock, general, osmotic, and universal stresses. Both mechanisms provide the causative agent of melioidosis with survival under conditions of prolonged cold stress at low positive temperatures. The first strategy showed greater efficiency at negative temperatures. The transition of B. pseudomallei to a viable but uncultivated state occurs in the long term (at least 2 years). While with the second strategy, this happens within 2 months. Assessment of the potential and molecular mechanisms of adaptation of this bacterium to cold stress is necessary to understand the degree of risk in case of a possible introduction of B. pseudomallei into regions with a temperate climate and to develop effective measures to ensure the biosafety of the environment.
REVISED STRATIGRAPHIC RELATIONSHIPS WITHIN THE LOWER FORT UNION FORMATION (TULLOCK MEMBER, GARFIELD COUNTY, MONTANA, U.S.A.) PROVIDE A NEW FRAMEWORK FOR EXAMINING POST K–PG MAMMALIAN RECOVERY DYNAMICS
Authors: WEAVER LUCAS N. , TOBIN THOMAS S. , CLAYTOR JORDAN R. , WILSON DEIBEL PAIGE K. , CLEMENS WILLIAM A. , WILSON MANTILLA GREGORY P. 
Published: April 2022

ABSTRACTThe Hell Creek region of northeastern Montana is an excellent study system to explore the rise to dominance of mammalian faunas after the Cretaceous–Paleogene (K–Pg) mass extinction. The Tullock Member of the Fort Union Formation exposed in that region was deposited during the first 1.2 Ma after the Chicxulub bolide impact. Some aspects of post-K–Pg mammalian succession remain obscure, however, due to a lack of finer stratigraphic resolution between vertebrate fossil localities. Here, we present a new stratigraphic model for the lower and middle Tullock and identify a stratigraphic succession of five mammal-bearing sedimentary units that span the first ∼ 900 ka of the Paleocene. Most notably, we find that middle Tullock fossil localities, which were previously thought to be deposited by a single, large fluvial channel complex, are derived from two temporally and lithologically distinct sedimentary units: the Biscuit Springs unit (BS) and the Garbani channel (GC). The top of the GC is stratigraphically above the top of the BS, but in some places cuts through the entirety of the BS, a relationship that previously complicated interpretations of their relative age. This cross-cutting relationship reveals that the BS is older than the GC. Thus, the BS local fauna represents a potential intermediate between the older local faunas from the post-K–Pg ‘disaster' interval and the younger, more taxonomically/ecologically diverse GC local fauna. This new stratigraphic framework sets the stage for future studies focused on the pattern and timing of biotic recovery in the aftermath of the K–Pg mass extinction.
Research
Authors: Liu Meng-juan 
Published: April 2022

Abstract
Maglev train is suspended through the surrounding track, which overcomes many disadvantages caused by the direct contact between the wheel and rail of traditional vehicles, such as excessive friction. It has the advantages of high speed, comfortable riding, less maintenance, strong climbing ability, and so on. However, when the train is running at high speed, it will be subjected to a strong unsteady aerodynamic load. The violent disturbance of aerodynamic load will inevitably lead to the corresponding feedback of electromagnetic force and the change of the suspension gap, which will affect the stability and safety of the train.
Higher Non-fasting Triglyceride also Predicts Higher Risks of Diabetes Mortality
Authors: Wang Yutang 
Published: April 2022

Abstract
Background: It has been shown that fasting triglyceride is positively associated with diabetes mortality. However, it is unknown whether this is true for non-fasting triglyceride. This brief report aimed to investigate the association of non-fasting triglyceride with diabetes mortality.Methods: This study included 7,313 US adults. Diabetes mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios of non-fasting triglyceride for diabetes mortality.Results: Non-fasting triglyceride was positively associated with baseline diabetes markers. A 1-natural-log-unit increase in non-fasting triglyceride was associated with a 132% higher multivariate-adjusted risk of diabetes diagnosis. During 122,940 person-years of follow-up (mean, 16.8 years), 420 diabetes-caused deaths were documented. A 1-natural-log-unit increase in non-fasting triglyceride was associated with a 41% higher multivariate-adjusted risk of diabetes mortality. Compared with people with non-fasting triglyceride in the lowest quintile, people with non-fasting triglyceride in the highest quintile had a 141% higher risk of diabetes mortality. The positive association between non-fasting triglyceride and diabetes mortality was also presented in participants with or without diabetes. Conclusions: This study found that non-fasting triglyceride was positively associated with diabetes mortality risks. Therefore, non-fasting triglyceride could be used to detect those with high risks of diabetes. The results of this study are clinically relevant given that non-fasting tests are more comfortable and convenient than fasting tests; they also support the initiatives by some guidelines to recommend the use of non-fasting triglyceride for general screening and risk evaluation.