bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiorespiratory response to early rehabilitation in critically ill adults: A secondary analysis of a randomised controlled trial
Authors: Eggmann Sabrina , Irincheeva Irina , Luder Gere , Verra Martin L. , Moser André , Bastiaenen Caroline H. G. , Jakob Stephan M. 
Published: February 2022

Introduction
Early rehabilitation is indicated in critically ill adults to counter functional complications. However, the physiological response to rehabilitation is poorly understood. This study aimed to determine the cardiorespiratory response to rehabilitation and to investigate the effect of explanatory variables on physiological changes during rehabilitation and recovery.

Methods
In a prospectively planned, secondary analysis of a randomised controlled trial conducted in a tertiary, mixed intensive care unit (ICU), we analysed the 716 physiotherapy-led, pragmatic rehabilitation sessions (including exercise, cycling and mobilisation). Participants were previously functionally independent, mechanically ventilated, critically ill adults (n = 108). Physiological data (2-minute medians) were collected with standard ICU monitoring and indirect calorimetry, and their medians calculated for baseline (30min before), training (during physiotherapy) and recovery (15min after). We visualised physiological trajectories and investigated explanatory variables on their estimated effect with mixed-effects models.

Results
This study found a large range of variation within and across participants’ sessions with clinically relevant variations (>10%) occurring in more than 1 out of 4 sessions in mean arterial pressure, minute ventilation (MV) and oxygen consumption (VO2), although early rehabilitation did not generally affect physiological values from baseline to training or recovery. Active patient participation increased MV (mean difference 0.7l/min [0.4–1.0, p<0.001]) and VO2 (23ml/min [95%CI: 13–34, p<0.001]) during training when compared to passive participation. Similarly, session type ‘mobilisation’ increased heart rate (6.6bpm [2.1–11.2, p = 0.006]) during recovery when compared to ‘exercise’. Other modifiable explanatory variables included session duration, mobilisation level and daily medication, while non-modifiable variables were age, gender, body mass index and the daily Sequential Organ Failure Assessment.

Conclusions
A large range of variation during rehabilitation and recovery mirrors the heterogenous interventions and patient reactions. This warrants close monitoring and individual tailoring, whereby the best option to stimulate a cardiorespiratory response seems to be active patient participation, shorter session durations and mobilisation.

Trial registration
German Clinical Trials Register (DRKS) identification number: DRKS00004347, registered on 10 September 2012.
Effects of a group-based weight management programme on anxiety and depression: A randomised controlled trial (RCT)
Authors: Heath Laura , Jebb Susan , Stevens Richard , Wheeler Graham , Ahern Amy , Boyland Emma , Halford Jason , Aveyard Paul 
Published: February 2022

ObjectivesThe aim was to investigate the impact of a group-based weight management programme on symptoms of depression and anxiety compared with self-help in a randomised controlled trial (RCT).MethodPeople with overweight (Body Mass Index [BMI]≥28kg/m2) were randomly allocated self-help (n = 211) or a group-based weight management programme for 12 weeks (n = 528) or 52 weeks (n = 528) between 18/10/2012 and 10/02/2014. Symptoms were assessed using the Hospital Anxiety and Depression Scale, at baseline, 3, 12 and 24 months. Linear regression modelling examined changes in Hospital Anxiety and Depression Scale between trial arms.ResultsAt 3 months, there was a -0.6 point difference (95% confidence interval [CI], -1.1, -0.1) in depression score and -0.1 difference (95% CI, -0.7, 0.4) in anxiety score between group-based weight management programme and self-help. At subsequent time points there was no consistent evidence of a difference in depression or anxiety scores between trial arms. There was no evidence that depression or anxiety worsened at any time point.ConclusionsThere was no evidence of harm to depression or anxiety symptoms as a result of attending a group-based weight loss programme. There was a transient reduction in symptoms of depression, but not anxiety, compared to self-help. This effect equates to less than 1 point out of 21 on the Hospital Anxiety and Depression Scale and is not clinically significant.
Nursing care recommendation for pediatric COVID-19 patients in the hospital setting: A brief scoping review
Authors: Efendi Defi , Hasan Faizul , Natalia Regina , Utami Ayuni Rizka , Sonko Ismaila , Asmarini Titik Ambar , Yuningsih Risna , Wanda Dessie , Sari Dian 
Published: February 2022

BackgroundThe hospitalization of children during the COVID-19 pandemic has affected their physical and mental health. Pediatric nurses have faced challenges in providing high-quality nursing care for children and their families. However, the pediatric nursing care recommendations for COVID-19 patients in the hospital setting remain unclear. The current scoping review provides recommendations for nursing interventions for pediatric COVID-19 patients in the hospital setting.Methods and findingsThe selected articles containing management and nursing recommendations for COVID-19 that have occurred in pediatric patients ages 0–19 years old. A search strategy was developed and implemented in seven databases. We included peer-reviewed articles that reported observational or interventional studies, as well as policy papers, guides or guidelines, letters and editorials, and web articles. A total of 134 articles and other documents relevant to this review were included. We categorized the results based on The Nursing Intervention Classification (NIC) taxonomy which consists of six domains (e.g., Physiological: Basic); eleven classes (e.g., Nutrition Support); and eighteen intervention themes (e.g., Positioning, Family Presence Facilitation, Family Support, and Discharge Planning).ConclusionApart from the intervention of physical problems, there is a need to promote patient- and family-centered care, play therapy, and discharge planning to help children and families cope with their new situation.
A protocol for the VISION study: An indiVidual patient data meta-analysis of randomised trials comparing MRI-targeted biopsy to standard transrectal ultraSound guided bIopsy in the detection of prOstate cancer
Authors: Kasivisvanathan Veeru , Chan Vinson Wai-Shun , Clement Keiran D. , Levis Brooke , Haider Masoom , Agarwal Ridhi , Emberton Mark , Pond Gregory R. , Takwoingi Yemisi , Klotz Laurence , Moore Caroline M. ,   VISION study collaborators
Published: February 2022

Background
Transrectal ultrasound (TRUS) guided biopsy for prostate cancer is prone to random and systemic error and has been shown to have a negative predictive value of 70%. PRECISION and PRECISE are among the first randomised studies to evaluate the new MRI-targeted biopsy (MRI-TB) pathway with a non-paired design to detect clinically significant prostate cancer and avoid unnecessary treatment. The trials’ results individually demonstrated non-inferiority of MRI-TB compared to TRUS biopsy. An individual patient data (IPD) meta-analysis was planned from the outset of the two trials in parallel and this IPD meta-analysis aims to further elucidate the utility of MRI-TB as the optimal diagnostic pathway for prostate cancer.

Methods and materials
This study is registered on PROSPERO (CRD42021249263). A search of Medline, Embase, Cochrane Central Register of Registered Trials (CENTRAL), Web of Science, and ClinicalTrials.gov was performed up until 4th February 2021. Only randomised controlled trials (PRECISE, PRECISION and other eligible trials) comparing the MRI-targeted biopsy pathway and traditional TRUS biopsy pathway will be included. The primary outcome of the review is the proportion of men diagnosed with clinically significant prostate cancer in each arm (Gleason ≥ 3+4 = 7). IPD and study-level data and characteristics will be sought from eligible studies. Analyses will be done primarily using an intention-to-treat approach, and a one-step IPD meta-analysis will be performed using generalised linear mixed models. A non-inferiority margin of 5 percentage points will be used. Heterogeneity will be quantified using the variance parameters from the mixed model. If there is sufficient data, we will investigate heterogeneity by exploring the effect of the different conducts of MRIs, learning curves of MRI reporting and MRI targeted biopsies.

Trial registration
This systematic review is registered on PROSPERO (CRD42021249263)
Effects of combined training on metabolic profile, lung function, stress and quality of life in sedentary adults: A study protocol for a randomized controlled trial
Authors: Ferreira José Pedro , Duarte-Mendes Pedro , Teixeira Ana M. , Silva Fernanda M. 
Published: February 2022

Background
Both physical inactivity and sedentary behavior are considered modifiable risk factors for chronic diseases and all-cause mortality. Adult office-workers spend most of their working day in sedentary behaviors, so they are particularly at high risk of developed chronic diseases (e.g., cardiovascular diseases, metabolic disorders like diabetes mellitus, …). It seems important to promote behavioral changes that could prevent or delay metabolic disease development. Evidence supports the use of exercise programs, however, to date there are several knowledge gaps and inconsistencies in the literature regarding the effects of Combined Training (i.e., aerobic plus resistance training) in sedentary healthy adults. This paper outlines an RCT designed to evaluate the effects of a 16-week combined training program on biochemical and immune markers of metabolic disease, lung function, salivary stress hormones and subjective quality of life (primary outcomes), as well as on body composition and physical fitness (secondary outcomes) in sedentary middle-aged office-workers. Furthermore, we aimed to assess the associations between the changes promoted by the exercise program and the different variables studied.

Methods and design
This is a single-blinded two-arm RCT with parallel groups. A minimum of healthy 40 office-workers aged 40–64 years will be recruited to engage in a 16-week intervention study. After baseline assessments, participants will be randomized to one of the two groups: (1) combined training group or (2) control group. Baseline assessments will be repeated after 8 weeks of intervention (mid-testing) and upon completion of the intervention (post-testing).

Discussion
This RCT involves a multi-disciplinary approach and seems to be a relevant contribution to understanding the potential role of combined training in improving the metabolic profile, lung function, stress, and quality of life in adults. The results can provide important insights for clinical recommendations and for the optimization of strategies to prevent metabolic disorders in adults with sedentary jobs.

Trial registration
This trial is registered with ClinicalTrials.gov (registration number: NCT04868240; date of registration April 30, 2021).
Predictors of mortality among hospitalized COVID-19 patients and risk score formulation for prioritizing tertiary care—An experience from South India
Authors: Gopalan Narendran , Senthil Sumathi , Prabakar Narmadha Lakshmi , Senguttuvan Thirumaran , Bhaskar Adhin , Jagannathan Muthukumaran , Sivaraman Ravi , Ramasamy Jayalakshmi , Chinnaiyan Ponnuraja , Arumugam Vijayalakshmi , Getrude Banumathy , Sakthivel Gautham , Srinivasalu Vignes Anand , Rajendran Dhanalakshmi , Nadukkandiyil Arunjith , Ravi Vaishnavi , Hifzour Rahamane Sadiqa Nasreen , Athur Paramasivam Nirmal , Manoharan Tamizhselvan , Theyagarajan Maheshwari , Chadha Vineet Kumar , Natrajan Mohan , Dhanaraj Baskaran , Murhekar Manoj Vasant , Ramalingam Shanthi Malar , Chandrasekaran Padmapriyadarsini 
Published: February 2022

Background
We retrospectively data-mined the case records of Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed COVID-19 patients hospitalized to a tertiary care centre to derive mortality predictors and formulate a risk score, for prioritizing admission.

Methods and findings
Data on clinical manifestations, comorbidities, vital signs, and basic lab investigations collected as part of routine medical management at admission to a COVID-19 tertiary care centre in Chengalpattu, South India between May and November 2020 were retrospectively analysed to ascertain predictors of mortality in the univariate analysis using their relative difference in distribution among ‘survivors’ and ‘non-survivors’. The regression coefficients of those factors remaining significant in the multivariable logistic regression were utilised for risk score formulation and validated in 1000 bootstrap datasets.
Among 746 COVID-19 patients hospitalised [487 “survivors” and 259 “non-survivors” (deaths)], there was a slight male predilection [62.5%, (466/746)], with a higher mortality rate observed among 40–70 years age group [59.1%, (441/746)] and highest among diabetic patients with elevated urea levels [65.4% (68/104)]. The adjusted odds ratios of factors [OR (95% CI)] significant in the multivariable logistic regression were SaO2<95%; 2.96 (1.71–5.18), Urea ≥50 mg/dl: 4.51 (2.59–7.97), Neutrophil-lymphocytic ratio (NLR) >3; 3.01 (1.61–5.83), Age ≥50 years;2.52 (1.45–4.43), Pulse Rate ≥100/min: 2.02 (1.19–3.47) and coexisting Diabetes Mellitus; 1.73 (1.02–2.95) with hypertension and gender not retaining their significance. The individual risk scores for SaO2<95–11, Urea ≥50 mg/dl-15, NLR >3–11, Age ≥50 years-9, Pulse Rate ≥100/min-7 and coexisting diabetes mellitus-6, acronymed collectively as ‘OUR-ARDs score’ showed that the sum of scores ≥ 25 predicted mortality with a sensitivity-90%, specificity-64% and AUC of 0.85.

Conclusions
The ‘OUR ARDs’ risk score, derived from easily assessable factors predicting mortality, offered a tangible solution for prioritizing admission to COVID-19 tertiary care centre, that enhanced patient care but without unduly straining the health system.
Imbricações da corporeidade negra na arte afro-brasileira contemporânea
Authors: André de Souza Mateus Raynner 
Published: February 2022

Artigo que visa investigar a presença do conceito de corporeidade negra na arte afro-brasileira contemporânea. Propõem-se que a corporeidade negra se caracteriza como um local para discursos na produção em artes visuais afro-brasileira. Verifica-se que a ancestralidade se hibridiza através do corpo com as linguagens da arte contemporânea, criando obras coletivas. Através de um levantamento bibliográfico, buscou-se responder à questão sobre possíveis relações e caminhos em pesquisas entre a corporeidade negra e a arte contemporânea. Pretendeu-se estimular a arte afro-brasileira contemporânea como um campo de pesquisas em/sobre arte.
Presença ambiental
Authors: Giannachi Gabriella , Augusto Gandara Federici Conrado , Souza Lobo Guzzo Marina 
Published: February 2022

Tradução de "Environmental presence", de Gabriella Giannachi. In: GIANNACHI, Gabriela; KAYE, Nick; SHANKS, Michael (org.). Archaeologies of Presence: Art, Performance and the persistence of being. Londres: Routledge: 2012. P. 50-63.
Diagnostic performance of the fully automated Roche Elecsys SARS-CoV-2 antigen electrochemiluminescence immunoassay: a pooled analysis
Authors: Lippi Giuseppe , Henry Brandon M. , Adeli Khosrow 
Published: February 2022

Abstract

Objectives
Among the diagnostic tests that have recently become commercially available for diagnosing coronavirus disease 2019 (COVID-19), the fully-automated Roche Elecsys severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen electrochemiluminescence immunoassay (ECLIA) is one of the most widespread for its adaptability within a system of laboratory automation, rapidity and high-throughput. This article is aimed to provide the results of the first pooled analysis of its accuracy for diagnosing SARS-CoV-2 infections.

Content
We carried out an electronic search in Scopus and Medline, without language or date restrictions (i.e., up to January 18, 2022), to identify articles where the diagnostic performance of Roche Elecsys SARS-CoV-2 antigen ECLIA was compared with that of reference molecular diagnostic techniques.

Summary
Overall, 11 studies were identified, 10 of which (n=6,095 swabs) provided necessary data for inclusion in a pooled analysis. The pooled diagnostic sensitivity, specificity and area under the curve (AUC) in nasopharyngeal samples were 0.68 (95%CI, 0.66–0.70), 0.99 (95%CI, 0.99–0.99) and 0.958 (95%CI, 0.936–0.980), respectively. The cumulative observed agreement with reference molecular assays was 89.5% and the kappa statistic was 0.735 (95%CI, 0.716–0.754). The pooled diagnostic sensitivity in samples with high viral load (i.e., cycle threshold values <28–30) was 0.95 (95%CI, 0.92–0.97).

Outlook
The results of this pooled analysis confirm that the fully-automated Roche Elecsys SARS-CoV-2 antigen ECLIA has high diagnostic specificity and optimal diagnostic sensitivity for identifying nasopharyngeal samples with higher viral load, thus making it a reliable technique for mass screening and for supporting strategies based on shorten isolation and/or quarantine.
Droplet epitaxy symmetric InAs/InP quantum dots for quantum emission in the third telecom window: morphology, optical and electronic properties
Authors: Holewa Paweł , Kadkhodazadeh Shima , Gawełczyk Michał , Baluta Paweł , Musiał Anna , Dubrovskii Vladimir G. , Syperek Marcin , Semenova Elizaveta 
Published: February 2022

Abstract
The rapidly developing quantum communication technology requires deterministic quantum emitters that can generate single photons and entangled photon pairs in the third telecom window, in order to be compatible with existing optical fiber networks and on-chip silicon photonic processors. InAs/InP quantum dots (QDs) are among the leading candidates for this purpose, due to their high emission efficiency in the required spectral range. However, fabricating versatile InAs/InP QD-based quantum emitters is challenging, especially as these QDs typically have asymmetric profiles in the growth plane, resulting in a substantial bright-exciton fine structure splitting (FSS). This hinders the generation of entangled photon pairs and thus, compromises the versatility of InAs/InP QDs. We overcome this by implementing droplet epitaxy (DE) synthesis of low surface density (2.8 × 108 cm−2) InAs
x
P1−x
QDs with x = (80 ± 15)% on an (001)-oriented InP substrate. The resulting QDs are located in etched pits, have concave bases, and most importantly, have symmetric in-plane profiles. We provide an analytical model to explain the kinetics of pit formation and QD base shape modification. Our theoretical calculations of electronic states reveal the properties of neutral and charged excitons and biexcitons confined in such QDs, which agree with the optical investigations of individual QDs. The optical response of QDs' ensemble suggests that FSS may indeed be negligible, as reflected in the vanishing degree of linear polarization. However, single QD spectrum gathered from an etched mesa shows moderate FSS of (50 ± 5) µeV that we link to destructive changes made in the QD environment during the post-growth processing. Finally, we show that the studied DE QDs provide a close-to-ideal single-photon emission purity of (92.5 ± 7.5)% in the third telecom window.
Efficient modal analysis of plasmonic nanoparticles: from retardation to nonclassical regimes
Authors: Yan Wei , Qiu Min 
Published: February 2022

Abstract
With recent developments in nanotechnologies, metal nanoparticles permeate a wide range of dimension scales, from light wavelength-scale domains down to a few nanometers approaching electronic scales. The electrodynamics at metal surfaces hosts a rich interplay between plasmon oscillations, retardation effects of light, and nonclassical (quantum) effects of electrons. Incorporating all these effects and modeling optical responses of nanoparticles generally rely on pure numerical methods, which are, however, disadvantageous in physical interpretations and computational speed. Herein, we establish a modal method that accurately predicts plasmon responses of metal nanoparticles, including both retardation and nonclassical corrections on an equal footing. The proposed method, based on electrostatic plasmon modes, is parameterized by a set of geometrically dependent factors, which, once computed, can be repeatedly used for same-shaped nanoparticles independent of size and material composition. The predictive accuracy of the method is examined for single nanoparticles, multi-scale plasmonic architectures—such as dimer structures with deep-nanometer gap—and geometrically deformed structures, with feature dimensions ranging from a few nanometers to hundreds of nanometers.
The crystal structure of [(2,2′-bipyridine-k2
N,N)-bis(6-phenylpyridine-2-carboxylato-k2
N,O)cobalt(II)]-monohydrate, C36H26N4O5Co
Authors: Tai Xi-Shi , Xia Yu-Pei 
Published: February 2022

Abstract
C36H26N4O5Co, monoclinic, C2/c (no. 15), a = 29.3826(17) Å, b = 10.3153(5) Å, c = 19.9407(12) Å, β = 107.263(6), V = 5771.6(6) Å3, Z = 8, R

gt
(F) = 0.0341, wR

ref
(F
2) = 0.0777, T = 200 K.
A practical review over surface modification, nanopatterns, emerging materials, drug delivery systems, and their biophysiochemical properties for dental implants: Recent progresses and advances
Authors: Akbari Edgahi Mohammadmahdi , Naghib Seyed Morteza , Emamian Amirhossein , Ramezanpour Hosseinali , Haghiralsadat Fatemeh , Tofighi Davood 
Published: February 2022

AbstractIn this paper, we reviewed the recent advances in nanoscale modifications and evaluated their potential for dental implant applications. Surfaces at the nanoscale provide remarkable features that can be exploited to enhance biological activities. Herein, titanium and its alloys are considered as the main materials due to their background as Ti-based implants, which have been yielding satisfactory results over long-term periods. At first, we discussed the survivability and the general parameters that have high impacts on implant failure and the necessities of nanoscale modification. Afterward, fabrication techniques that can generate nanostructures on the endosseous implant body are categorized as mechanical, chemical, and physical methods. These techniques are followed by biomimetic nanotopographies (e.g., nanopillars, nanoblades,etc.) and their biological mechanisms. Alongside the nanopatterns, the applications of nanoparticles (NPs) including metals, ceramics, polymers,etc., as biofunctional coating or delivery systems are fully explained. Finally, the biophysiochemical impacts of these modifications are discussed as essential parameters for a dental implant to provide satisfactory information for future endeavors.