bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bibliometric analysis of the research on preeclampsia in the first two decades of the twenty-first century
Authors: Zheng Dongying , Khan Muhanmmad , Zhang Guangyao , Song Kedong , Wang Lixia , Qiao Chong , Kang Fuli 
Published: March 2022

Background:
Preeclampsia still remains one of the leading causes of maternal and perinatal mortality worldwide. Despite the concerted efforts of researchers, only a little improvement has been seen. Clinical decision-making is based on the published literatures. With the explosive growth of medical documents in recent decades, a bibliometric method is essential for assessing the intellectual contributions, major components and potential trends.

Methods:
Web of Science Core Collections was selected as the original database and datasets were retrieved consisting of literatures published from 2000 to 2020. Different bibliometric software were employed to visualize the co-authorship network, citation analysis and research theme detection.

Results:
A total of 25497 articles and 3668 reviews were obtained. Despite the number of publications increased annually, the quantity of high-quality contributions did not elevate accordingly. Clinical practitioners should be alerted to the false bloom of achievements and the yield of improvement in future research. Nicolaides Kypros H was found to be the most productive and influential researcher. University of Pittsburgh was the most productive institution whereas Harvard University showed its leading academic status. America located at the central point in global collaboration and scholarship network. Reference citation analysis revealed the top landmark articles. Moreover, keywords co-occurrence analysis and burst detection certificated the lack of novel themes in this field, which needs further efforts.

Conclusion:
This study provides the overall landscape of science mapping in recent two decades in the field of preeclampsia, with the aim of identifying evolution of research topics and promoting potential concentration or collaboration in the future.
Isolated Rib Fractures in Elderly Falls: Not As Deadly As We Think
Authors: Cull John D. , Ewing Alex , Metcalf Ashley , Kitchens Debra , Manning Benjamin 
Published: March 2022

BACKGROUND:
Rib fractures in elderly patients have been associated with high morbidity and mortality; however, many of these patients had substantial mechanisms of injury, which may have contributed to these high rates.

OBJECTIVE:
The purpose of this study was to determine the morbidity and mortality of elderly patients with isolated rib fractures who fell from standing.

METHODS:
A single-institution retrospective study was conducted in a Level I trauma center using the trauma registry and a separate elderly fall from standing database. Admitted patients 65 years or older who presented with rib fractures after a fall from January 2013 to June 2017 were included. Patients with a nonthoracic Abbreviated Injury Scale score greater than 2 were excluded from the study.

RESULTS:
Of 129 patients with isolated rib fracture, 94% (n = 121) had comorbidities and 71% (n = 92) had two or more comorbidities. Almost half (41.9%; n = 54) were taking antiplatelet and anticoagulant medications, 78.3% (n = 101) were caused by a mechanical fall, and 7% (n = 9) were caused by syncope. Data showed 72.9% (n = 94) had three or more rib fractures. The mortality rate of patients was 3.9% (n = 5). Three patients had dementia at death, four had do-not-resuscitate order, and only two deaths were directly related to pulmonary status. Patients who developed pneumonia (14.7%; n = 19) and required mechanical ventilation for a median of 11 days (3.9%; n = 5) were fewer than those in in previous studies.

CONCLUSION:
The morbidity and mortality associated with rib fractures are significantly less than reported in the literature when additional injuries are excluded.
Patient Preparedness for Pelvic Organ Prolapse Surgery: A Randomized Equivalence Trial of Preoperative Counseling
Authors: Sassani Jessica C. , Grosse Philip J. , Kunkle Lauren , Baranski Lindsey , Ackenbom Mary F. 
Published: March 2022

(Abstracted from Female Pelvic Med Reconstr Surg 2021;27:719–725)
Patient preparedness before surgery—a patient's readiness to undergo surgery, their related perioperative expectations, and postoperative satisfaction—has been shown to positively affect postoperative satisfaction and surgical outcomes. In a urogynecologic population, increased patient preparedness has been associated with improved symptoms and quality of life.
Endoscopic Removal of a Nasopharyngeal Foreign Body Stuck Within the Sphenoid Bone Using the Endonasal Transseptal Approach
Authors: Nakayama Yuki , Suzuki Jun , Ohta Jun 
Published: March 2022

Abstract:
Nasopharyngeal foreign bodies (FBs), which are generally caused by a strong, external force, are seldomly encountered. Removing these FBs is challenging for otorhinolaryngological surgeons because of the vital structures surrounding the nasopharynx, such as the skull base, cranial nerves, and internal carotid artery. Here, the authors report the case of a 69-year-old man referred to our hospital after accidentally cutting his face while using a grinder. Grinder fragments were deeply embedded in the face, thus becoming nasopharyngeal FBs. The authors evaluated three-dimensional volume rendering images and immediately removed these FBs using an endoscopic endonasal transseptal approach under general anesthesia. The postoperative course was uneventful. Using the endoscopic endonasal transseptal approach after evaluating preoperative three-dimensional volume rendering images may help eliminate nasopharyngeal FBs safely.
Posterior Vault Distraction Outcomes in Patients With Severe Crouzon Syndrome Resulting from Ser347Cys and Ser354Cys Mutations
Authors: Raposo-Amaral Cassio Eduardo , Raposo-Amaral Cesar Augusto , Adams Jason W. , Ghizoni Enrico 
Published: March 2022

Background:
In this study, the authors present the outcomes of 4 patients with a severe form of Crouzon syndrome characterized by mutation of fibroblast growth factor receptor 2 (FGFR2) c.1040 C > G p.Ser347Cys or the pathogenic c.1061C > G p.Ser354Cys variant of FGFR2, who underwent posterior vault distraction osteogenesis (PVDO) to alleviate elevated intracranial pressure.

Methods:
Patients with diagnosed Crouzon syndrome who were found by genetic testing to have an FGFR2 c.1040 C > G p.Ser347Cys mutation or the c.1061C > G p.Ser354Cys variant were included. Outcome data and presence of hydrocephalus, Chiari Malformation type I (CMIs), and the presence/absence of a tracheostomy were recorded.

Results:
Three patients with the FGFR2 c.1040 C > G p.Ser347Cys mutation and 1 with the pathogenic FGFR2 c.1061C > G p.Ser354Cys variant were identified as having characteristics of severe Crouzon syndrome. The mean age at PVDO was 15 months and the mean posterior advancement was 20 mm. All 4 patients experienced sufficient relief of the elevated intracranial pressure from the PVDO to prevent the need for shunt placement, stabilize the ventricular dimensions (n = 2), and resolve the CMIs (n = 2). Intracranial pressure screening ruled out malignant cerebrospinal fluid volume increase.

Conclusions:
PVDO effectively prevented hydrocephalus and resolved CMIs, successfully alleviating intracranial pressure and maximizing clinical outcomes for patients with severe Crouzon syndrome.
Condylar Fractures: Multistep Surgical Planning by Mini-Invasive Approach, Patient Series
Authors: Cortese Antonio , Catalano Salvatore , Rauso Raffaele , Claudio Pier Paolo 
Published: March 2022

Purpose:
Surgical treatment for condylar fractures is a challenging procedure most debated in scientific literature without a broad consensus on the selection of surgical techniques to be used and relative indications.
The goal of this work is to propose a multistep surgical planning for condylar fractures based on an effective mini-invasive approach and safe procedure aimed to avoid as much as possible skin incision in the aesthetic areas of the face and neck, to decrease the risk of facial nerve injury.

Methods:
Ten patients with dislocated condylar neck fractures and sub-condylar fractures were included in this study.
All the patients were studied with radiological images, computed tomography scans with three-dimensional reconstructions preoperatively and immediate postoperatively.
Patients were evaluated pre- and post-operatively for dental occlusion, bone fragment alignment after reduction and after fixation, facial nerve functionality, skin scarring, temporomandibular joint functionality, temporomandibular joint symptomatology, and patient satisfaction.

Results:
Results were satisfactory for different parameters evaluated. No significant complications resulted in follow-up, particularly for facial nerve injury. By using this multistep procedure with each stage functional to the following one, the authors achieved satisfactory results following treatment of dislocated condylar fractures.
Hepatic Artery Infusion Pumps
Authors: Sharib Jeremy M. , Creasy John M. , Wildman-Tobriner Benjamin , Kim Charles , Uronis Hope , Hsu Shiaowen David , Strickler John H. , Gholami Sepideh , Cavnar Michael , Merkow Ryan P. , Kingham Peter , Kemeny Nancy , Zani Sabino , Jarnagin William R. , Allen Peter J. , D’Angelica Michael I. , Lidsky Michael E. 
Published: March 2022

Background:
Hepatic artery infusion (HAI) is a liver-directed therapy that delivers high-dose chemotherapy to the liver through the hepatic arterial system for colorectal liver metastases and intrahepatic cholangiocarcinoma. Utilization of HAI is rapidly expanding worldwide.

Objective and Methods:
This review describes the conduct of HAI pump implantation, with focus on common technical pitfalls and their associated solutions. Perioperative identification and management of common postoperative complications is also described.

Results:
HAI therapy is most commonly performed with the surgical implantation of a subcutaneous pump, and placement of its catheter into the hepatic arterial system for inline flow of pump chemotherapy directly to the liver. Intraoperative challenges and abnormal hepatic perfusion can arise due to aberrant anatomy, vascular disease, technical or patient factors. However, solutions to prevent or overcome technical pitfalls are present for the majority of cases. Postoperative HAI-specific complications arise in 22% to 28% of patients in the form of pump pocket (8%–18%), catheter (10%–26%), vascular (5%–10%), or biliary (2%–8%) complications. The majority of patients can be rescued from these complications with early identification and aggressive intervention to continue to deliver safe and effective HAI therapy.

Conclusions:
This HAI toolkit provides the HAI team a reference to manage commonly encountered HAI-specific perioperative obstacles and complications. Overcoming these challenges is critical to ensure safe and effective pump implantation and delivery of HAI therapy, and key to successful implementation of new programs and expansion of HAI to patients who may benefit from such a highly specialized treatment strategy.
High frequency and persistence of Anti-DSG2 antibodies in post COVID-19 serum samples
Authors: Lee Edward , Tyler Ryan E. , Johnson Derrick , Koh Natalie , Chi Ong Biauw , Foo Shi Yin , Tan Jack 
Published: March 2022

AbstractBackgroundThere is growing recognition that COVID-19 does cause cardiac sequelae. The underlying mechanisms involved are still poorly understood to date. Viral infections, including COVID-19, have been hypothesized to contribute to autoimmunity, by exposing previously hidden cryptic epitopes on damaged cells to an activated immune system Given the high incidence of cardiac involvement seen in COVID-19, our aim was to determine the frequency of anti-DSG2 antibodies in a population of post COVID-19 patients.Methods and Results300 convalescent serum samples were obtained from a group of post COVID-19 infected patients from October 2020 to February 2021. 154 samples were drawn 6 months post-COVID-19 infection and 146 samples were drawn 9 months post COVID infection. 17 samples were obtained from the same patient at the 6- and 9-month mark. An electrochemiluminescent-based immunoassay utilizing the extracellular domain of DSG2 for antibody capture was used. The mean signal intensity of anti-DSG2 antibodies in the post COVID-19 samples was significantly higher than that of a healthy control population (19+/−83.2 vs. 2.1+/−6.8, P value <0.001). Of note, 29.3% of the post COVID-19 infection samples demonstrated a signal higher than the 90th percentile of the control population and 8.7% were higher than the median found in ARVC patients. The signal intensity between the 6-month and 9-month samples did not differ significantly.ConclusionsWe report for the first time that recovered COVID-19 patients demonstrate significantly higher and sustained levels of anti-DSG2 autoantibodies as compared to a healthy control population, comparable to that of a diagnosed ARVC group.
Conceptualization, operationalization, and utilization of race and ethnicity in major medical journals 1995-2018: a systematic review
Authors: Martinez Rae Anne M. , Wilbur Rachel E. , Andrabi Nafeesa , Goodwin Andrea N. , Smith Natalie R. , Zivich Paul N. 
Published: March 2022

ABSTRACTBackgroundSystemic racial and ethnic inequities continue to be perpetuated through scientific methodology and communication norms despite efforts by medical institutions.PurposeTo characterize methodological practices regarding race and ethnicity in U.S. research published in leading medical journals.Data sourceArticles published in Annals of Internal Medicine, BMJ, JAMA, The Lancet, and NEJM from 1995-2018 were sampled via PubMed.Study SelectionAll original, human subjects research conducted in the U.S.Data ExtractionInformation on definition, measurement, coding, use in analyses, and justifications was collected.Data SynthesisThe proportion of U.S. medical research studies including race and/or ethnicity data increased between 1995 and 2018. No studies defined race or ethnicity. and most did not state how race and/or ethnicity was measured. Common coding schemes included: “Black, other, White,” “Hispanic, Non-Hispanic,” and “Black, Hispanic, other, White.” Race and/or ethnicity was most often used as a control variable, descriptive covariate, or matching criteria. Under 30% of studies included justification for their methodological choices regarding race and/or ethnicity.ConclusionsDespite regular efforts by medical journals to implement new policies around race and ethnicity in medical research, pertinent methodological information was systematically absent from the majority of reviewed literature. This stymies critical disciplinary reflection and progress towards equitable practice.
Functional Determination of Calcium Binding Sites Required for the Activation of Inositol 1,4,5-trisphosphate receptors
Authors: Arige Vikas , Terry Lara E. , Wagner Larry E. , Baker Mariah R. , Fan Guizhen , Serysheva Irina I. , Yule David I. 
Published: March 2022

AbstractInositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca2+) signals in response to various external cues. Notably, IP3R channel activity is determined by several obligatory factors including IP3, Ca2+ and ATP. The critical basic amino acid residues in the N-terminal IP3-binding core (IBC) region that facilitate IP3 binding are well characterized. In contrast, the residues conferring the biphasic regulation by Ca2+ are yet to be ascertained. Using comparative structural analysis of Ca2+ binding sites identified in two main families of intracellular Ca2+-release channels, ryanodine receptors (RyRs) and IP3Rs, we identified putative acidic residues coordinating Ca2+ in the cytosolic calcium sensor region in IP3Rs. We determined the consequences of substituting putative Ca2+ binding, acidic residues in IP3R family members. We show that the agonist-induced Ca2+ release, single channel open probability (P0) and Ca2+ sensitivities are markedly altered when the negative charge on the conserved acidic side chain residues are neutralized. Remarkably, neutralizing the negatively charged side chain on two of the residues individually in the putative Ca2+ binding pocket shifted the Ca2+ required to activate IP3R to higher concentrations, indicating that these residues likely are a component of the Ca2+ activation site in IP3R. Taken together, our findings indicate that Ca2+ binding to a well conserved activation site is a common underlying mechanism resulted in increased channel activity shared by IP3Rs and RyRs.
Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell function
Authors: Rodrigues-dos-Santos Karina , Roy Gitanjali , Binns Derk D. , Grzemska Magdalena G. , Barella Luiz F. , Armoo Fiona , McCoy Melissa K. , Huynh Andrew V. , Yang Jonathan Z. , Posner Bruce A. , Cobb Melanie H. , Kalwat Michael A. 
Published: March 2022

ABSTRACTPancreatic islet beta cells require a fine-tuned ER stress response for normal function; abnormal ER stress contributes to diabetes pathogenesis. Here, we identified a small molecule, SW016789, with time-dependent effects on beta cell ER stress and function. Acute treatment with SW016789 potentiated nutrient-induced calcium influx and insulin secretion, while chronic exposure to SW016789 transiently induced ER stress and shut down secretory function in a reversible manner. Distinct from the effects of thapsigargin, SW016789 did not affect beta cell viability or apoptosis, potentially due to a rapid induction of adaptive genes, weak signaling through the eIF2α kinase PERK, and lack of oxidative stress gene Txnip induction. We determined that SW016789 acted upstream of voltage-dependent calcium channels (VDCCs) and potentiated nutrient- but not KCl-stimulated calcium influx. Measurements of metabolomics, oxygen consumption rate, and G protein-coupled receptor signaling did not explain the potentiating effects of SW016789. In chemical co-treatment experiments we discovered synergy between SW016789 and activators of protein kinase C (PKC) and VDCCs, suggesting involvement of these pathways in the mechanism of action. Finally, chronically elevated calcium influx was required for the inhibitory impact of SW016789, as blockade of VDCCs protected human islets and MIN6 beta cells from hypersecretion-induced dysfunction. We conclude that beta cells undergoing this type of pharmacological hypersecretion have the capacity to suppress their function to mitigate ER stress and avoid apoptosis. These results have the potential to uncover beta cell ER stress mitigation factors and add support to beta cell rest strategies to preserve function.
Phenotypic Variation from Waterlogging in Multiple Perennial Ryegrass Varieties under Climate Change Conditions
Authors: Frisk Carl A. , Xistris-Songpanya Georgianna , Osborne Matthieu , Biswas Yastika , Melzer Rainer , Yearsley Jon M. 
Published: March 2022

AbstractIdentifying how various components of climate change will influence ecosystems and vegetation subsistence will be fundamental to mitigate negative effects. Climate change-induced waterlogging is understudied in comparison to temperature and CO2. Grasslands are especially vulnerable through the connection with global food security, with perennial ryegrass dominating many flood-prone pasturelands in North-western Europe. We investigated the effect of long-term waterlogging on phenotypic responses of perennial ryegrass using four varieties grown in atmospherically controlled growth chambers (ambient vs 2050, +2°C and eCO2) during two months of peak growth. Using image analysis and PCA methodologies, we assess how multiple predictors (phenotypic, environmental, genetic and temporal) influence overall plant performance and productivity. Long-term waterlogging was found to reduce leaf-colour intensity, with younger plants having purple hues indicative of anthocyanins. Plant performance and yield was lower in waterlogged plants, with tetraploid varieties coping better than diploid ones. The climate change treatment was found to reduce colour intensities further. Flooding was found to reduce plant productivity via reductions in colour pigments and root proliferation. These effects will have negative consequences for global food security from facing extreme weather events and flooding. Our approach can be adapted as plant health diagnostics tools via remote sensing and drone-technology.
Impacts of recreational angling on fish population recovery after a commercial fishing ban
Authors: Dainys Justas , Jakubavičiūtė Eglė , Gorfine Harry , Kirka Mindaugas , Raklevičiūtė Alina , Morkvėnas Augustas , Pūtys Žilvinas , Ložys Linas , Audzijonyte Asta 
Published: March 2022

AbstractIt is often assumed that recreational fishing has negligible impact on fish stocks compared to commercial fishing. Yet, for inland water bodies in densely populated areas, this is unlikely to be true. In this study we demonstrate remarkably variable stock recovery rates among different fish species with similar life histories in a large productive inland freshwater ecosystem (Kaunas Reservoir, Lithuania), where all commercial fishing has been banned since 2013. We conducted over 900 surveys of recreational anglers during a period of four years (2016 to 2021) to assess recreational fishing catches. These surveys are combined with drone and fishfinder device-based assessment of recreational fishing effort. Fish population recovery rates were assessed using standardised catch per unit effort time series. We show that recreational fishing is having a major impact in retarding the recovery of predatory species, such as pikeperch and perch. In contrast, recovery of roach, rarely caught by anglers, has been remarkably rapid and the species is now dominating the ecosystem. Our study demonstrates that recreational fishing can have strong impacts on some fish species, alter relative species composition and potentially change ecosystem state and dynamics.
Ependymal cell maturation is heterogeneous and ongoing in the mouse spinal cord and dynamically regulated in response to injury
Authors: Rodrigo Albors Aida , Singer Gail A. , May Andrew P. , Ponting Chris P. , Storey Kate G. 
Published: March 2022

SummaryThe spinal cord neural stem cell potential resides within the ependymal cells lining the central canal. These cells are, however, heterogeneous, and we know little about the biological diversity this represents. Here we use single-cell RNA-sequencing to profile adult mouse spinal cord ependymal cells. We uncover transcriptomes of known subtypes and a new mature ependymal cell state, that becomes more prominent with age. Comparison of ependymal cell transcriptomes from the brain and spinal cord revealed that ongoing cell maturation distinguishes spinal cord ependymal cells from their postmitotic brain counterparts. Using an ex vivo model of spinal cord injury, we show that ependymal cell maturation is reversible but also highly regulated. We revisit ependymal cell identities in adult human spinal cord and uncover evidence for their maturation and surprising ventralisation with age. This first in-depth characterisation of spinal cord ependymal cells paves the way to manipulation of distinct ependymal subtypes, provides insights into ependymal cell maturation dynamics and informs strategies for coaxing ependymal cell-driven spinal cord repair.