bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mood stabilizer lithium slows down synaptic vesicle cycling at glutamatergic synapses
Authors: Tang Willcyn , Cory Bradley , Lim Kah-Leong , Fivaz Marc 
Published: July 2022

Abstract
Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is known, however, about its mode of action. Here, we analyzed the impact of lithium on synaptic vesicle (SV) cycling at presynaptic terminals releasing glutamate, a neurotransmitter previously implicated in BD and other neuropsychiatric conditions. We used the pHluorin-based synaptic tracer vGpH and a fully automated image processing pipeline to quantify the effect of lithium on both SV exocytosis and endocytosis in hippocampal neurons. We found that lithium selectively reduces SV exocytic rates during electrical stimulation, and markedly slows down SV recycling post-stimulation. Analysis of single bouton responses revealed the existence of functionally distinct excitatory synapses with varying sensitivity to lithium ― some terminals show responses similar to untreated cells, while others are markedly impaired in their ability to recycle SVs. While the cause of this heterogeneity is unclear, these data indicate that lithium interacts with the SV machinery and influences glutamate release in a large fraction of excitatory synapses. Together, our findings show that lithium down modulates SV cycling, an effect consistent with clinical reports indicating hyperactivation of glutamate neurotransmission in BD.
3D kinematic characteristics of lumbar facet joints in sitting position
Authors: Han Ye , Li Kepeng , Wang Xiaodong , Wang Jianzhong , Sun Shaosong , Xia Xi , Wang Jing , Miao Jun 
Published: July 2022

Abstract
Background: Recognizing the kinematic characteristics of lumbar facet joints is important for the prevention and treatment of lumbar degenerative diseases. Previous studies have been conducted in either the supine or standing position, and there are no measurements regarding the kinematic characteristics of the lumbar facet joints while sitting. The aim of this study was to measure and analyze lumbar facet joint motion characteristics while sitting.Methods: Ten subjects (5 males and 5 females) performed the movements of flexion-extension, left bending-right bending, and left rotation-right rotation in a sitting position. Dual Fluoroscopic Image System and computed tomography technique were used to measure the displacement and rotation angle of the lumbar facet joints of the subjects for analysis. The movement characteristics of L3-S1 were measured. Results: When the subjects were in sitting position, the lumbar vertebra mainly changed in Z axis and α, β angle when they performed flexion-extension activities. The displacement of the left facet joint was 4.65 ± 1.99 mm at L3-4, 1.89 ± 2.99 mm at L4-5, and 0.80 ± 2.27 mm at L5-S1 in the Z axis, and the displacement of the right facet joint was 3.20 ± 2.61 mm at L3-4, 1.71 ± 3.00 mm at L4-5, and 0.31 ± 1.69 mm at L5-S1 in the Z axis. The rotation in the α angle was 6.00 ± 4.49 ° at L3-4, 3.51 ± 5.24 ° at L4-5, and 0.97 ± 4.13 ° at L5-S1, which was significant different. The rotation in the β angle was 2.30 ± 2.94 °at L3-4, 0.16 ± 2.06 ° at L4-5, and 0.35 ± 1.74 °at L5-S1, which was significant different. When the lumbar spine performed the activity of left bending-right bending, there were changes in rotation mainly in the Z axis and β angle. The displacement of left facet joint in the Z axis was 1.34 ± 2.84 mm at L3-4, 2.11 ± 0.88 mm at L4-5 , and 0.72 ± 0.81 mm at L5-S1; the rotation in the β angle was 5.66 ± 2.70°at L3-4, 7.89 ± 2.59 ° at L4-5, and 1.28 ± 2.07 ° at L5-S1; when the lumbar spine performed the activity of left rotation-right rotation, there were changes in the β angle. The rotation of β angle was 4.09 ± 2.86 ° at L3-4, 2.14 ± 3.38 ° at L4-5, and 0.63 ± 1.85 ° at L5-S1.Conclusion: The lumbar facet joint motion in sitting position is different in each mode of motion. The horizontal displacement and rotation are predominant during flexion and extension activities, while there are different rotation in bending and rotation. The study shows the coupled motion of the lumbar facet joints while sitting, providing a new perspective on the kinematics of the lumbar spine and the etiology of lumbar degenerative diseases.
Deep learning model for predicting the presence of stromal invasion of breast cancer on digital breast tomosynthesis
Authors: Shimokawa Daiki , Takahashi Kengo , Oba Ken , Takaya Eichi , Usuzaki Takuma , Kadowaki Mizuki , Kawaguchi Kurara , Adachi Maki , Kaneno Tomofumi , Fukuda Toshinori , Yagishita Kazuyo , Tsunoda Hiroko , Ueda Takuya 
Published: July 2022

Abstract
Purpose:To develop a deep learning (DL)-based algorithm to predict the presence of stromal invasion of breast cancer on digital breast tomosynthesis (DBT).Materials and Methods:The institutional review board approved this retrospective study and waived the requisite to obtain the informed consent from the patients. Initially, 499 patients (mean age of 50.5 years, ranging from 29 to 90 years) who were referred to our hospital suggestive of breast cancer and performed DBT between March 1, 2019 and August 31, 2019, were enrolled in this study. Out of the 499 patients, 140 patients who were performed surgery with diagnosed breast cancer were finally selected. Based on the pathological reports, 140 patients were divided to be categorized as 20 patients with non-invasive cancer and 120 patients with invasive cancer. Xception architecture was used for the DL model to differentiate non-invasive cancer and invasive cancer. Diagnostic performance of the DL model was assessed by accuracy, sensitivity, specificity, and areas under the receiver operating characteristic curve (AUC).Results:The average accuracy, sensitivity, specificity, and AUC were 0.897, 0.909, 0.758, and 0.749, respectively.Conclusion:The proposed DL model trained on DBT images is useful to predict the presence of stromal invasion of breast cancer.Secondary abstractThe proposed deep learning (DL) model trained on digital breast tomosynthesis (DBT) images is useful to predict the presence of stromal invasion of breast cancer.
Seismic site-effects assessment in a fluvial sedimentary environment: case of Oued Martil floodplain, Northern Morocco
Authors: HILALI Mohamed EL , BOUNAB Ali , TIMOULALI Youssef , MESSARi Jamal STITOU , AHNICHE Mohamed 
Published: July 2022

Abstract
In Northern Morocco, seismic site effects in general and liquefaction hazard in particular can occur in the event of a major earthquake due to the thick sedimentary cover characterizing the peripheral Neogene basins of the Alboran Sea. An example is Martil Plain which was the subject of important economic development during the last two decades. In this regard, we present in this study as assessment of seismic site-effect hazard through the HVSR method and the Kg index. MASW and coredrilling data are also used to complete our analysis and interpret the spatial distribution of Kg maps. Our findings suggest more vulnerability to liquefaction in the Southern segment of the basin, which can be explained by the asymmetrical geometry of Quaternary sedimentation, due to tectonic uplift that influences also the surface and subsurface hydrology processes. As a result, some districts, especially those classified as economically disadvantaged, are found to be the most exposed to this hazard, which must be taken into consideration in future risk reduction and mitigation plans. We conclude the existence of significant seismic effects potential despite the moderate seismicity of the area. Therefore, our research needs to be completed by scenario based seismic hazard modelling to investigate the capacity of seismic events at the region to produce the above suggested amplifications.
Fluctuation of gut microbiome in Cirrhinus mrigala is associated with changes in dissolved oxygen of water
Authors: Basak Chandana , Mondal Nibendu , Chatterjee Sumit , Ghosh Wriddhiman , Chakraborty Ranadhir 
Published: July 2022

Abstract
Oxygen depletion, or hypoxia, a common consequence of eutrophication, has an adverse effect on aquatic flora and fauna. Bacteria living within or around aquatic macroorganisms struggle to thrive in low dissolved oxygen (DO2) conditions. The goal of our study was to see how the bacterial population in the intestine of a bottom-feeding fish, Cirrhinus mrigala, fluctuated when the DO2 level in the water decreased from 7±0.5 ppm to 0.35± 0.05 ppm. The V3 regions of 16S rRNA genes derived out of metagenome extracted from the intestines of control and experimental fishes were sequenced and analysed. The findings revealed that during DO2 stress (0.35±0.05 ppm), the aerobic bacterial population in the gut (existing when fish lived in 7±0.5 ppm DO2) changed significantly, transforming the microbial community into a facultative and/or obligate anaerobic community with the dominance of microaerophilic bacterial populations; density of Cetobacterium increased in intestinal samples, which is linked to the prevention of paradoxical anaerobicity in fish tissues. The current research advances our understanding of the changes in gut microbiome ecology of intestinal bacterial flora under DO2 stress.
Subsampling under distributional constraints
Authors: COMBES Florian , FRAIMAN Ricardo , GHATTAS Badih 
Published: July 2022

Abstract
Some complex models are frequently employed to describe physical and mechanical phenomena. In this setting we have an input X in a general space, and an output Y = f(X) where f is a very complicated function, whose computational cost for every new input is very high. We are given two sets of observations of X, S1 and S2 of different sizes such that only f(S1) is available. We tackle the problem of selecting a subset S3 ⊂ S2 of smaller size on which to run the complex mode f, and such that the empirical distribution of f(S3) is close to that of f(S1). We suggest three algorithms to solve this problem and show their efficiency using simulated datasets and the Airfoil self-noise data set.
Monkeypox infection in a developed country: A Case Report
Authors: Patalon Tal , Perez Galit , Melamed Guy , Wolf Tamar , Gazit Sivan 
Published: July 2022

Abstract
Describing patient journeys of monkeypox in a developed country, as it is manifested in the current outbreak, as well as rapidly sharing information as a lesson from the early days of the SARS-CoV-2 pandemic.
Melt-blown Fabric/SWCNTs Composites via the Dry and Binder-free Coating Process for Thermal Regulation and Electromagnetic Interference Shielding
Authors: Cao Jun , Zhang Zhao , Dong Haohao , Ding Yuanlong , Chen Ruihao , Liao Yongping 
Published: July 2022

Abstract
Conductive textiles with good flexibility and durability are highly demanded for wearable electronics. However, the common approaches of making conductive textiles requires multi-steps solvent processes, which is tedious and environment unfriendly. Herein, the high-quality single-walled carbon nanotubes (SWCNTs), synthesized by the floating catalyst chemical vapor deposition (FCCVD) method, were direct and dry coated on the melt-blown fabrics (MBFs) recycled from the waste masks with chemical binder-free. The obtained MBF/SWCNTs composites displayed excellent conductivity and flexibility and thus, can be further used as wearable and heatable textiles. The sheet resistance of MBF/SWCNTs composites can be further reduced by gold chloride (AuCl3) doping from 57 to 26 Ω/sq. The electrical-thermal measurement turned out the pristine MBF/SWCNTs composites can reach the surface temperature of ~ 48°C at a low voltage (5 V), while it increased to ~ 110°C after AuCl3 doping at the same voltage. In addition, the AuCl3 doped MBF/SWCNTs film with thickness of ~ 150 µm displays a high electromagnetic interference (EMI) shielding efficiency of 27.1 dB at X-band. Also, the MBF/SWCNTs composites displayed good stability after long-term heating, bending and washing. Our multi-functional MBF/SWCNTs textiles not only demonstrated the reusability of waste masks but also showed great potential applications in EMI and heat management, such as thermotherapy pads and fast water evaporators.
The Development of an Egg Incubator Prototype with the Use of Heat on the Condenser Side of the Refrigerator
Authors: Budiastawan Ngurah Putu , Wiratmaja I Gede , Nugraha I Nyoman Pasek 
Published: July 2022

<p>The development for an egg incubator prototype with the use of heat on the condenser side of the refrigerator belongs to Research and Development (R&amp;D) conductment with the aim of knowing the process of developing an egg incubator prototype by using heat on the condenser side of the refrigerator to find out the feasibility level. The method in this study uses Quality Function Deployment (QFD), which is a method used in the early stages of product design and development that makes quality design of a product based on the market quality demand and order of the customer. The prototype development process undergo several stages, including: preliminary survey to the farmer community, design, instrument validity testing, prototype making, media export testing and small group testing. Based on the calculation of the results of the validity test assessment by the instrument content expert, the content validity value of 1 which refers to the instrument validity criteria table is included in the very high validity criteria. Furthermore, based on the calculation of the validation results from the media expert test and the small group test, it gets a percentage of 100% for the media expert test and a percentage of 95.20% for the small group test and refers to the eligibility level qualification table with a scale of 5 in the very appropriate category without the need for revision, so that the developed prototype egg incubator are suitable for use and marketable for the industry.</p>
Commodification of Betawi culture of Palang Pintu festival
Authors: Mansur Suraya , Saragih Nurhayani , Novianti Wiwik , Istiyanto S Bekti , Mahligai Utas 
Published: July 2022

The Kemang Palang Pintu Festival is an annual event. The purpose of this event is to preserve culture and celebrate the anniversary of the city of Jakarta. The organizers display many Betawi cultural arts while visitors who come are not only Betawi residents. This study uses a constructivist qualitative approach. The research method used is a case study by conducting interviews direct observation to make observations. The technique of checking the validity of the data is using the source triangulation technique. The results of this study indicate that the Kemang Palang Pintu Festival has carried out good planning. Starting from selection of participants, the technical meeting of event agenda, to the mechanism of the event rundown. Have conducted a visitor satisfaction survey but have not processed the data as a reference for the next implementation. The technique of compiling messages has been well designed in order to attract visitors and convey the meaning of the message that is the purpose of the event. This doorstop festival is a commodity process that provides selling power. The advantages in this case are various forms, both material and non-material (the existence of sanggar studios).
Hegemonic dialectics between power and resistance in the Indonesian sharing economy: Study of Gojek
Authors: Asih Irsanti Widuri , Nugroho Heru , Budiawan Budiawan 
Published: July 2022

Gojek is an Indonesian platform-based on-demand ride-hailing business that has attracted some researchers to conduct studies in this newly emerged economy field through various approaches. Most researchers see the phenomenon of Gojek as part of the global disruptive technology movement that positively impacts the Indonesian economic and socio-cultural aspects of society. Some others expose the asymmetrical relationship between the platform and its driverpartners. No study analyzed it from the perspective of a dialectical hegemony that transpires between the platform and its driver-partners. Using a qualitative method, this article will fill in the gaps in the study of the Gojek phenomenon from the Gramscian Theory of Hegemony perspective to uncover the dialectical relationship between the digital platform and its driver-partners. The platform articulates hegemony actions through gamification and algorithm system, the concept of work, the internalization of corporate values, the Award Programs, the Kopi Darat Program, the driver-partners communities, Gojek’s Task Force and the driver-partners influencers. The driver-partners perform resistance by conducting demonstrations and boycotts, using various application modifications, and serving over one platform.
Using a Digital Approach to Improving Mental Health in Adults With Self-reported Psoriasis: An Analysis of Real-world User Data
Authors: Boucher Eliane , Honomichl Ryan , Zucker Murray 
Published: July 2022

Background
Visible scales and perceived stigma often lead to feelings of embarrassment, shame, low self-esteem, and self-consciousness among people with psoriasis. Beyond the negative effects of this distress on mental health, some researchers also argue that the inflammatory response caused by psoriasis predisposes patients with psoriasis to mental health conditions like depression. Given that anxiety and depression are linked to higher disease activity and pain in patients with psoriasis, researchers have argued that an important component of any psoriasis management plan should include addressing mental health. However, a shortage of mental health professionals, particularly in low income and rural areas, makes access to mental health care more challenging than many other common referrals—a problem that has been exacerbated in light of the COVID-19 pandemic.

Objective
This study aims to explore the feasibility of using a digital mental health intervention to help improve subjective well-being and anxiety among adults with self-reported psoriasis.

Methods
Real-world users who signed up for the digital wellness program, Happify, between January 1, 2017, and June 10, 2021, and who reported having psoriasis during onboarding were included in this analysis. To qualify, users had to complete at least two in-app assessments (which include a proprietary measure of subjective well-being, the Happify Scale, and the Generalized Anxiety Disorder 2 scale to measure anxiety), complete at least 1 Happify activity, complete no more than 3 activities before taking their first assessment, and had to have at least 42 days between their first and last assessment. We examined changes in well-being and anxiety among these participants based on Happify use (recommended vs less than recommended).

Results
Users who engaged with the program at the recommended level experienced significantly greater improvements in both well-being (P<.001) and anxiety (P=.01). More specifically, users who completed the recommended number of activities improved their well-being scores by 26.8%, whereas users who completed fewer activities improved their well-being scores by only 4.11%. Similarly, users who completed the recommended number of activities improved their anxiety scores by 26.64%, compared to 8.15% among those who engaged below the recommended level.

Conclusions
These data suggest that a digital mental health intervention can effectively improve both subjective well-being and anxiety among patients with psoriasis when used at the recommended level. Although future research is required to better understand whether this subsequently impacts disease-specific outcomes, such as disease activity and pain, our data suggest that a digital approach may be one method of providing greater access to mental health support for patients with psoriasis, increasing the likelihood that it can be incorporated into their treatment plan.

Conflicts of Interest
None declared.
Impact of COVID-19–related Isolation on Individuals in Treatment for Substance Use
Authors: Ondrusek Ashlin Ripley , Townsend Emily , Warnock Charles , Lowe Sarah , Muilenburg Jessica , Kershaw Trace 
Published: July 2022

Background
For individuals in treatment for substance use, supportive social networks are essential to protect against a return to use.

Objective
This study aimed to explore the impact of the swift and severe isolation brought on by the COVID-19 pandemic, specifically for individuals in treatment for substance use disorder, by exploring the relationships amongst social connectedness and isolation to treatment accessibility, mental health, and substance use.

Methods
A total of 24 semistructured interviews were conducted from May 2020 to August 2020 with participants engaged in substance use treatment asking about the impact of the pandemic on social networks, substance use, access to treatment, and mental health. Interviews were coded and analyzed using grounded theory.

Results
Results centered around two main themes: (1) access to support (eg, formal and informal networks) and (2) individual outcomes regarding substance use and worsened mental health.

Conclusions
This research suggests that the COVID-19 pandemic has greatly disrupted access to resources for individuals in treatment for substance use, and calls for treatment centers and governing bodies to put more resources into telehealth and alternative treatment plans in the event of major disruptions, such as national disasters and global pandemics.

Conflicts of Interest
None declared.