bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique collateralisation between the left internal thoracic artery and the coeliac artery
Authors: Patel S , McWilliams R , Neequaye S 
Published: April 2022

Collateralisation around stenotic or occlusive arterial disease is a commonly observed adaptation for maintenance of arterial perfusion. It occurs through pathways of well-understood embryological origin. Examples include Winslow’s pathway (internal thoracic artery to iliac artery via the epigastric arteries) and the arc of Riolan (between superior and inferior mesenteric arteries). In this article, we describe a pathway of collateralisation around stenotic disease of the coeliac and superior mesenteric arteries in a 76-year-old man with an abdominal aortic aneurysm. The collateral pathway was identified on computed tomography angiography between the left internal thoracic artery in the thorax and the coeliac artery in the abdomen via the left inferior phrenic artery. This has implications for routine cardiac surgery, such that left internal thoracic artery harvest during coronary artery bypass surgery would likely result in acute ischaemia of the abdominal viscera.
Polarization-dependent LIF/Mie ratio for sizing of micrometric ethanol droplets doped with Nile red
Authors: Koegl Matthias , Dai Hongfei , Baderschneider Kevin , Ulrich Hannah , Zigan Lars 
Published: April 2022

The present study deals with droplet sizing based on laser-induced fluorescence (LIF) and Mie scattering for varied polarization of the utilized laser (parallel or perpendicular). The polarization-dependent LIF/Mie ratio is studied for micrometric droplets (25–60 µm) produced with a droplet generator. The investigations were carried out with the dye Nile red dissolved in ethanol and ethanol/iso-octane mixtures. A spectral absorption and fluorescence characterization at various dye and ethanol concentrations is carried out in a cuvette in order to identify reabsorption effects. The

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droplet images (index

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: parallel polarization) show a more homogeneous intensity distribution in the droplets and slightly stronger morphology-dependent resonances (MDRs) in comparison to

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(index

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: perpendicular polarization). The spectral LIF emissions reveal a dependence of the MDR on the ethanol admixture. The larger the ethanol content, the lower the MDR peak, which is also shifted further to the red part of the spectrum. The Mie droplet signal images are mainly characterized by two distinct glare points, one at the entrance of the laser light (reflection) and one at the exit (first-order refraction). The

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images show a more pronounced entrance glare point, in comparison to

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, where the exit glare point is more pronounced. These observations are in accordance with the theory. The calibration curve of the micro droplet signals revealed a volumetric trend of the LIF signals and a slightly higher

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signal and sensitivity in comparison to

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. The signal

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follows roughly a quadratic trend on average, while

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follows a linear trend. Consequently, the calculated

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/

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ratio shows a linear trend, whereas the

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ratio shows a quadratic trend, which confirms theoretical calculations. A numerical simulation of the Mie signal at various detection angles shows a good agreement with the experimental data at large apertures.
Optimal opportunistic screening of atrial fibrillation using pulse palpation in cardiology outpatient clinics: Who and how
Authors: Bañeras Jordi , Pariggiano Ivana , Ródenas-Alesina Eduard , Oristrell Gerard , Escalona Roxana , Miranda Berta , Rello Pau , Soriano Toni , Gordon Blanca , Belahnech Yassin , Calabrò Paolo , García-Dorado David , Ferreira-González Ignacio , Radua Joaquim 
Published: April 2022

Background
Atrial fibrillation (AF) remain a prevalent undiagnosed condition frequently encountered in primary care.

Objective
We aimed to find the parameters that optimize the diagnostic accuracy of pulse palpation to detect AF. We also aimed to create a simple algorithm for selecting which individuals would benefit from pulse palpation and, if positive, receive an ECG to detect AF.

Methods
Nurses from four Cardiology outpatient clinics palpated 7,844 pulses according to a randomized list of arterial territories and durations of measure and immediately followed by a 12-lead ECG, which we used as the reference standard. We calculated the sensitivity and specificity of the palpation parameters. We also assessed whether diagnostic accuracy depended on the nurse’s experience or on a list of clinical factors of the patients. With this information, we estimated the positive predictive values and false omission rates according to very few clinical factors readily available in primary care (age, sex, and diagnosis of heart failure) and used them to create the algorithm.

Results
The parameters associated with the highest diagnostic accuracy were palpation of the radial artery and classifying as irregular those palpations in which the nurse was uncertain about pulse regularity or unable to palpate pulse (sensitivity = 79%; specificity = 86%). Specificity decreased with age. Neither the nurse’s experience nor any investigated clinical factor influenced diagnostic accuracy. We provide the algorithm to select the ≥40 years old individuals that would benefit from a pulse palpation screening: a) do nothing in <60 years old individuals without heart failure; b) do ECG in ≥70 years old individuals with heart failure; c) do radial pulse palpation in the remaining individuals and do ECG if the pulse is irregular or you are uncertain about its regularity or unable to palpate it.

Conclusions
Opportunistic screening for AF using optimal pulse palpation in candidate individuals according to a simple algorithm may have high effectiveness in detecting AF in primary care.
Early cost-effectiveness analysis of screening for preeclampsia in nulliparous women: A modelling approach in European high-income settings
Authors: Zakiyah Neily , Tuytten Robin , Baker Philip N. , Kenny Louise C. , Postma Maarten J. , van Asselt Antoinette D. I. ,   on behalf of IMPROvED Consortium
Published: April 2022

Background
Preeclampsia causes substantial maternal and perinatal morbidity and mortality and significant societal economic impact. Effective screening would facilitate timely and appropriate prevention and management of preeclampsia.

Objectives
To develop an early cost-effectiveness analysis to assess both costs and health outcomes of a new screening test for preeclampsia from a healthcare payer perspective, in the United Kingdom (UK), Ireland, the Netherlands and Sweden.

Methods
A decision tree over a 9-month time horizon was developed to explore the cost-effectiveness of the new screening test for preeclampsia compared to the current screening strategy. The new test strategy is being developed so that it can stratify healthy low risk nulliparous women early in pregnancy to either a high-risk group with a risk of 1 in 6 or more of developing preeclampsia, or a low-risk group with a risk of 1 in 100 or less. The model simulated 25 plausible scenarios in a hypothetical cohort of 100,000 pregnant women, in which the sensitivity and specificity of the new test were varied to set a benchmark for the minimum test performance that is needed for the test to become cost-effective. The input parameters and costs were mainly derived from published literature. The main outcome was incremental costs per preeclampsia case averted, expressed as an incremental cost-effectiveness ratio (ICER). Deterministic and probabilistic sensitivity analyses were conducted to assess uncertainty.

Results
Base case results showed that the new test strategy would be more effective and less costly compared to the current situation in the UK. In the Netherlands, the majority of scenarios would be cost-effective from a threshold of €50,000 per preeclampsia case averted, while in Ireland and Sweden, the vast majority of scenarios would be considered cost-effective only when a threshold of €100,000 was used. In the best case analyses, ICERs were more favourable in all four participating countries. Aspirin effectiveness, prevalence of preeclampsia, accuracy of the new screening test and cost of regular antenatal care were identified as driving factors for the cost-effectiveness of screening for preeclampsia.

Conclusion
The results indicate that the new screening test for preeclampsia has potential to be cost-effective. Further studies based on proven accuracy of the test will confirm whether the new screening test is a cost-effective additional option to the current situation.
Analisis Aspek Konteks, Input, Proses, Produk Pelayanan Telemedicine Pada Masa Pandemi Covid-19 (Studi Kasus : Rumah Sakit Ortopedi Prof. Dr. R. Soeharso Surakarta)
Authors: Fananni Rizqi Annisa Nur , Wigati Putri Asmita , Nandini Nurhasmadiar 
Published: April 2022

ABSTRACTBackground: The existence of the Covid-19 pandemic that hit the whole world, especially in Indonesia, had a significant impact on the health sector, especially in the provision of health services for the community. With this condition, the Indonesian government began to develop long-distance services (Telemedicine), where these services are aimed at preventing the spread of Covid-19, especially in health care facilities, as well as providing convenience for the community to reach health services during the Covid-19 pandemic. Of several hospitals in Surakarta, Prof. Dr. R. Soeharso Orthopedic Hospital is one of the hospitals that develops telemedicine services during the Covid-19 pandemic. From this, an overall analysis is needed regarding the implementation of telemedicine services whether they are appropriate and can achieve their goals and have a significant level of use and impact during the Covid-19 pandemic. Thus, this study aims to analyze the context, input, process, and product aspects of telemedicine services during the Covid-19 pandemic. Method: This research was conducted using the CIPP theory by Daniel L. Stufflebeam (1966) which consists of aspects of context, input, process, and product. This study uses qualitative research methods with data collection carried out by in-depth interviews selected based on purposive sampling.Results: The results showed that the operation of telemedicine services was carried out due to the Covid-19 pandemic condition with the aim of providing complete services to patients during the Covid-19 pandemic, lack of socialization regarding guidelines for implementing telemedicine to related implementing staff, poor coordination in the planning process, the inclusion of telemedicine into the annual and five-year planning of the Prof. Dr. R. Soeharso Orthopedic, there is no report to the authorities regarding telemedicine services, there is no patient satisfaction survey regarding the telemedicine services provided.
Literary Spoils of War in Uppsala in Practice – Controversial Theology
Authors: Sjökvist Peter 
Published: April 2022

Religious conflicts did not only take place on battlefields in the 17th century, but in far wider contexts. We see them also in propaganda, poetry, sermons and academic discourse. When the literary spoils of war were taken by the Swedish from Catholic libraries in Poland to the Lutheran Uppsala University, many books were not highly valued. These Catholic books ended up stored separately from the ‘sound and pure’ volumes found in the first library building in Uppsala. In this article, it is shown how these Catholic books did at times prove useful, at least in the field of polemical theology. In fact, teaching at the university took an increasingly anti-Catholic direction after the arrival of the collections from Braniewo and Frombork to Uppsala, with the main confessional enemy apparently being Robert Bellarmine.
Chinese university students’ self-regulated writing strategy use and EFL writing performance: influences of self-efficacy, gender, and major
Authors: Shen Bin , Bai Barry 
Published: April 2022

Abstract
Self-regulated (SRL) writing strategy use is considered a potent method for improving writing performance. Motivational regulation, an underresearched aspect of SRL, has become more recognized in SRL models recently. The present study aims to depict the interplay among SRL writing strategies and English writing performance. It also examined the influences of motivational regulation writing strategies on English writing performance, and whether such relationship would be mediated by other SRL writing strategies. Endeavors were also made to evaluate the moderation effects of gender and major, and the predictive effects of self-efficacy. Teng, L. S. & L. J. Zhang. 2016a. A questionnaire-based validation of multidimensional models of self-regulated learning strategies. Modern Language Journal 100(3). 674–701. Writing Strategies for Self-regulated Learning Questionnaire was administered to 340 university students in China, and their English writing test scores were collected. Structural equation modeling results verified the hypothesized partial mediation model with both direct and indirect paths from motivational regulation strategies to English writing performance. Cognitive and metacognitive strategies both served as mediators while social strategies failed to do so. No moderation effect of gender and major was found. Learners’ writing self-efficacy beliefs predicted their use of SRL writing strategies, with the strongest effects on motivational regulation strategies. Pedagogical implications are drawn.
Improvement of the thermoelectric properties of GeTe- and SnTe-based semiconductors aided by the engineering based on phase diagram
Authors: Li Junqin , Liu Fusheng , Ao Weiqin , Hu Lipeng , Zhang Chaohua 
Published: April 2022

Abstract
Group IV–VI semiconductors, such as PbTe, GeTe and SnTe, are promising thermoelectric materials at intermediate temperatures, which have potential application in electrical generation from waste heat. A phase diagram plays an important role for designing a high-performance material. In this mini review, we present the enhancement of the thermoelectric properties of GeTe- and SnTe-based semiconductors based on their phase diagrams. The figure of merit ZT for the p-type GeTe–Ag8GeTe6 composites was enhanced by reducing the thermal conductivity significantly using the eutectic microstructures formed by the Ag8GeTe6 second phase and the GeTe matrix based on the GeTe–Ag8GeTe6 pseudo-binary system. The partial substitution of Te by Se in p-type GeTe extends the solid solubility of Pb in GeTe0.5Se0.5 up to 30 mol.%, which further improves the thermoelectric properties of alloys in the GeTe–PbTe–Se system by modifying the carrier concentration, leading to increasing the Seebeck coefficient and reducing thermal conductivity over a wide composition range. The Sn1−y
Mn
y
Te alloy with 10 at.% excess Mn keeps its composition change along the SnTe–MnTe tie line and receives higher solid solubility of MnTe in SnTe. It shows much higher thermoelectric performance since the excess Mn compensates the Mn lost during the preparation as compared to the Sn1−x
Mn
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Te alloy without excess Mn.
Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats
Authors: Armenia Armenia , Wahyuni Fatma Sri , Almahdy Almahdy , Abdillah Rahmad , Aquista Popy Genca , Putri Diana Puspita , Zikra Murhamah 
Published: April 2022

Abstract

Objectives
Antioxidants protect people from diabetes and its cardiovascular complication. Purified gambir (Uncaria gambir Roxb.) is a potential medicinal plant for treating this condition based on the antioxidant activity of its catechin compound. This study tries to reveal the potential activity of purified gambir as a blood pressure-lowering drug while lowering blood glucose in diabetic hypertensive rats induced by oral NaCl-Prednisone and Alloxan.

Methods
Rats were induced by oral NaCl 0.8% and Prednisone 5 mg/kg BW for 14 days to obtain hypertensive condition. Alloxan 125 mg/kg BW was given intra peritoneal injection on the 8th day to obtain diabetic hypertensive condition. The animal was divided into five groups, normal control group treated with vehicle, treatment groups were treated with purified gambir at dose of 2.5; 5 and 10 mg/kg BW respectively, while the positive control group were treated with a combination of captopril-glibenclamide at dose of 2.25 and 0.45 mg/kg BW. All animals were treated orally for 14 days. Fasting blood glucose and cardiovascular parameters (SBP, DBP, MAP, HR, BF and BV) were measured on days 1, 3, 7, and 14. NO level were measured on day 0 and day 14. Data were analyzed using two-way ANOVA followed by Duncan Multiple Range Test.

Results
The purified gambir has blood pressure and blood sugar-lowering activity (p<0.05). The NO levels of the treatment group also increased significantly (p<0.05).

Conclusions
This study indicated that purified gambir could be an alternative medicine to manage blood glucose and blood pressure in the diabetic hypertensive model.
Financial conflicts of interest during meetings of the cardiovascular and renal drugs advisory committee
Authors: Bertolino Blake , Kinder Nicholas , Cooper Craig , Gray Harrison , Arthur Wade , Ahlander Joseph , Simpson Alainna , Vassar Matt 
Published: April 2022

Abstract

Context
The Cardiovascular and Renal Drugs Advisory Committee (CRDAC) of the Food and Drug Administration (FDA) reviews safety and efficacy data for cardiovascular and renal drugs, ultimately making recommendations to the Commissioner of Food and Drugs for approval. The Open Public Hearing segment of these meetings allows for patients, advocates, healthcare professionals, clinical trialists, and members of the public to provide testimony, which often results in expressing their preference for, or against, drug approval. Prior to providing testimony, the public speakers are highly encouraged to disclose any financial conflicts of interest (FCOIs) with the sponsor or other groups. Given the potential influence of these speakers on drug approval recommendations, we investigated the industry associations disclosed by public speakers in the Open Public Hearing section of the CRDAC meetings. Previous studies, such as one done by Lurie et al. indicated that positive testimony is tied to a higher likelihood of drug approval, and because drug companies provide financial compensation for speakers to provide testimony in general, we wanted to determine the likelihood with which speakers who have an FCOI provided a positive testimony vs. those without any FCOI.

Objectives
The purpose is to evaluate whether public speakers with an FCOI are more likely to provide positive testimony regarding the drug in question during the CRDAC of the FDA between February 2009 and December 2019 through the use of publicly available transcripts.

Methods
Independent researchers investigated public transcripts and minutes of the CRDAC meetings with public speakers (n=20). We identified all speakers, along with characteristics such as an FCOI, and classified statements utilizing a pilot-tested Google form. The data collected were analyzed utilizing Stata. The speaker’s testimony was then compared with their FCOI. An ordered logistic regression was performed utilizing the speaker’s testimony regarding the drug as the dependent variable.

Results
Of the 88 speakers represented in our sample, 35 (35/88, 39.8%) disclosed an FCOI, most commonly regarding travel cost. Among speakers with an FCOI, 30 (30/35, 85.7%) spoke positively. Speakers with an FCOI were 4.96 times more likely to provide positive testimony (OR=4.96, 95% CI 1.67–14.78). Speakers with the disease were also more likely to provide positive testimony (OR=13.05, 95% CI 2.84–59.93).

Conclusions
Public speakers often play a role during meetings, and they may also have an FCOI, most commonly related to travel expenses. Our study shows that speakers with an FCOI are more likely to provide positive testimony. Stipulations, such as requiring disclosure of FCOI and randomizing the selection process of speakers, can help ensure the integrity of the drug approval process.
First trimester examination of fetal anatomy: clinical practice guideline by the World Association of Perinatal Medicine (WAPM) and the Perinatal Medicine Foundation (PMF)
Authors: Volpe Nicola , Sen Cihat , Turan Sifa , Sepulveda Waldo , Khalil Asma , Rolnik Daniel L , De Robertis Valentina , Volpe Paolo , Gil Mar M , Chaveeva Petya , Dagklis Themistoklis , Pooh Ritsuko , Kosinski Przemyslaw , Cruz Jader , Huertas Erasmo , D’ Antonio Francesco , Rodriguez Calvo Jesus , Daneva Markova Ana 
Published: April 2022

Abstract
This recommendation document follows the mission of the World Association of Perinatal Medicine in collaboration with the Perinatal Medicine Foundation. We aim to bring together groups and individuals throughout the world for precise standardization to implement the ultrasound evaluation of the fetus in the first trimester of pregnancy and improve the early detection of anomalies and the clinical management of the pregnancy. The aim is to present a document that includes statements and recommendations on the standard evaluation of the fetal anatomy in the first trimester, based on quality evidence in the peer-reviewed literature as well as the experience of perinatal experts around the world.
Is Finitude Original? A Rereading of “Violence and Metaphysics”
Authors: Rolfsen Theodor Sandal 
Published: April 2022

Abstract
This article seeks to challenge what may seem to be an obvious assertion: that finitude is original in the sense that it must be presupposed that any possible meaning can only be thought beginning from this finitude. I do this through a rereading of Derrida’s epochal essay “Violence and Metaphysics,” which perhaps is the most decisive interpretation of the philosophy of Emmanuel Levinas. In the essay, Derrida demonstrates how Levinas is forced to betray his own intentions in his attempt to describe the Other as transcendent. By making use of a newly published lecture series, Derrida held at the same time as writing the essay, I show how Derrida’s reading of Levinas is intimately tied to his interpretation of Heidegger’s critique of the metaphysics of presence, and how both Levinas and Derrida end up in the paradox I call “original finitude.” I then show how new commentary literature on Levinas’ analysis of enjoyment gives us an alternative to Derrida’s notion of original finitude. I do not propose that this alternative overcomes Derrida’s problematic, but rather that it gives another option of how to relate to that which escapes the grasp of philosophy. The key difference will be whether transcendence is conceived as a failure of philosophy or its excess.