bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS RANTAI DAN MARGIN PEMASARAN IKAN ASIN DI KECAMATAN RUMBIA TENGAH KABUPATEN BOMBANA
Authors: Fitriani - , Budiyanto - , Lawelle Sjamsu Alam 
Published: March 2022

ABSTRAKPenelitian ini bertujuan untuk mengetahui rantai pemasaran ikan, mengetahui margin pemasaran ikan asin pada masing-masing rantai pemasaran dan mengetahui efisiensi pemasaran pada masing-masing rantai pemasaran di Kecamatan Rumbia Tengah Kabupaten Bombana. Penelitian ini dilakukan pada bulan Januari sampai bulan Februari 2019. Populasi dalam penelitian ini adalah pemilik usaha ikan asin yang berjumlah 25 orang. Analisis yang digunakan dalam penelitian ini menggunakan deskriptif kualitatif dan kuantitatif dari margin pemasaran dan mengetahui tingkat efisiensi pemasaran dengan menggunakan rumus farmers share.Hasil penelitian menunjukkan bahwa Rantai pemasaran ikan asin yaitu Ikan barakuda terdiri dari satu rantai yaitu rantai II dari pengolah ke pengumpul, kemudian langsung ke konsumen akhir, ikan selar kuning, ikan tembang, ikan jakueja dan ikan campuran terdiri dari dua rantai yaitu rantai I dari pengolah ke pedagang pengecer kemudian langsung ke konsumen akhir. Margin pemasaran ikan selar kuning pada rantai I sebesar Rp. 16.000/kg, ikan tembang dan ikan campuran menghasilkan margin sebesar Rp. 13.000/kg dan ikan jakueja menhasilkan margin sebesar Rp. 15.000. Sedangkan pada rantai pemasaran II pada ikan barakuda menghasilkan margin sebesar Rp. 21.000/kg, ikan selar kuning dan ikan merah sebesar Rp. 17.000/kg, ikan tembang dan ikan campuran sebesar Rp. 15.000/kg. Efisensi pemasaran tertinggi masing-masing rantai pemasaran adalah ikan tembang dan ikan campuran sebesar 54% terdapat pada rantai I. Sedangkan efisiensi pemasaran terendah adalah ikan selar kuning, ikan tembang, ikan jakueja dan ikan campuran sebesar 50% terdapat pada rantai II. Pemasaran ikan asin di Kecamatan Rumbia Tengah tergolong efisien.Kata Kunci : Rantai, Margin Pemasaran, dan Efisiensi Pemasaran Ikan Asin
ANALISIS PEMASARAN RAJUNGAN (PORTUNUS PELAGICUS) DI DESA TANJUNG BUNGA KECAMATAN WAWOLESEA KABUPATEN KONAWE UTARA
Authors: Dafirudin - , Budiyanto - , Mansyur Akhmad 
Published: March 2022

ABSTRAK Penelitian ini dilakukan di Desa Tanjung Bunga Kecamatan Wawolesia Kabupaten Konawe Utara pada bulan Februari sampai Maret 2019, dapat untuk mengetahui saluran pemasaran dan margin pemasaran rajungan.Jumlah responden dalam penelitian ini adalah 10 orang Data yang diperoleh melalui metode sensus melalui wawancara secara langsung dengan menggunakan kuesioner. Variabel penelitian diukur dan diamati adalah harga, margin, dan biaya. Hasil penelitian menunjukan terdapat 1(satu) saluran pemasaran rajungan yaitu nelayan akan menjual hasil tangkapannya kepedagang pengumpul kemudian pedagang pengumpul akan mengolah rajungan menjadi barang setengah jadi dan dikirim ke PT. Ocean Cham Safood di Kota Kendari. Perusahaan tersebut akanmendistribusikan keperusahan yang ada di Kota Makasar. Total biaya yang dikeluarkan oleh pedagang pengumpul sebesar Rp400.5000 dan pedagang besar sebesar Rp560.000. Besaran margin pengumpul sebesar Rp80.000/Kg, dan pedagang besar sebesar Rp30.000/Kg. Batas pemasaran di pembeli lebih memuaskan daripada enceran karena proses pengelolaanya. Kata Kunci : Batas, Penangkapan Kepiting, Pemasaran
Investigation of the Effects of Amlodipine on Paracetamol- Induced Acute Kidney Toxicity in Rats
Authors: KARATAS Erdogan , BAYRAKTUTAN Zafer , ÇADIRCI Elif 
Published: March 2022

Objective: Paracetamol is an analgesic and antipyretic agent that widely used throughout the world. The increase of the usage and its easy accessibility brings along the toxicity risk. Paracetamol toxicity may result in drug induced hepatotoxicity and nephrotoxicity. Anti-inflammatory and antioxidant effects of amlodipine which creates vasodilatation by blocking L-type calcium channels and its usage in elderly for renoprotective purposes, ponders that it might be favorable in cases with inflammation such renal damage inducted with paracetamol. Thus, aim of our study is to analyze effects of amlodipine, one of L-type calcium channel blockers, in acute renal damage inducted with paracetamol.
Methods: 30 male rats consisting of 5 groups were used in our study. Groups; I: Health Control group. 2 ml Phosphate-buffered saline (PBS) oral was administered. II: 10 mg/kg Amlodipine III: Paracetamol (2g/kg) IV: 5 mg/kg Amlodipine + paracetamol V: 10 mg/kg Amlodipine + paracetamol. Rats were sacrificed after 24 hours following paracetamol administration.
Results: Serum levels of creatinine and blood urea nitrogen (BUN) were increased in paracetamol group, those parameters improved in amlodipine groups. While superoxide dismutase (SOD) activity and glutathione (GSH) levels measured in kidney decreased in paracetamol group, amlodipine has significantly corrected these parameters. Meanwhile malondialdehyde (MDA) quantities increased in paracetamol group, it has been seen that in the amlodipine administered groups quantities of increased MDA have statistically significantly decreased
Conclusion: This study showed that amlodipine has protective effects against paracetamol toxicity in kidney. Amlodipine revealed its protective effects by suppressing the oxidative damage and improving antioxidant activity. Amlodipine can be drug of choice in hypertensive patients with analgesic nephropathies.
An Assessment of Menstrual and Genital Hygiene Behaviours among Adolescent Females at Gazimağusa, Northern Cyprus
Authors: MAMUK Rojjin , PARLAN Hasret , ASİF Eren , DEVECİ Mürüvvet , AKDENİZ Ebru 
Published: March 2022

Objective: Inadequate menstrual and genital hygiene behaviours are common and important problems for adolescent health. This study aims to determine menstrual and genital hygiene behaviours and the affecting factors among female students enrolled in high schools located in Gazimağusa, Northern Cyprus.
Methods: This school-based, cross-sectional, and descriptive study was conducted in three high schools in the Gazimağusa town borders in Northern Cyprus with 379 students. Data were collected through the Socio-demographic Form and the Genital Hygiene Behaviours Scale.
Results: The scale mean score was found 79,28±6,80 (min:47 / max: 112). The factors affecting menstrual and genital hygiene behaviours were found to be the type of schools the students were enrolled (X2: 14,771 / P: 0,001), the education level of the mothers (X2: 9,806 / P: 0,020), and the education level of the fathers (X2: 15,879 / P:0,001).
Conclusions: The participants of this study had an above-average level of right genital hygiene behaviours. Genital hygiene behaviours were found to be affected by the type of school, the education level of the mothers, and the education level of the fathers.
Dental Anxiety And Cardiovascular Response Changes In Multiple Implant Surgery – An Observational Study
Authors: GÜLNAHAR Yakup , KÜPELİ İlke 
Published: March 2022

Objective: The aim of the study is to observe the level of anxiety and its relationship with cardiovascular changes in each implant in the patients with a high number of implants applied in a single session.
Methods: In the prospective observational study, 100 patients, who had undergone 4 or more implant surgeries in the same session electively, were included in the study. Demographic data of each patient were recorded. After Corah Dental Anxiety Scale (C-DAS) was applied to the patients 10 minutes before the surgery, standard heart rate (HR), saturation, systolic (SAP), and diastolic (DAP) blood pressure monitorization were performed and the measured values were recorded during surgery and 30 minutes after the end of the procedure, and the surgery period were recorded.
Results: It was determined that the mean age of the cases was 52.0±11.7 and the number of implants was 5.8±1.5, and the surgery periodwas 53.7 ± 18 minutes. There was a positive correlation between HR and CDAS at all times and as the number of implants increased, SAP and DAP were added to this correlation (p
Distinct Immune Response at 1 Year Post-COVID-19 According to Disease Severity
Authors: Kang Chang Kyung , Kim Minji , Hong Jisu , Kim Gwanghun , Lee Soojin , Chang Euijin , Choe Pyoeng Gyun , Kim Nam Joong , Kim Ik Soo , Seo Jun-Young , Song Daesub , Lee Dong-Sup , Shin Hyun Mu , Kim Yong-Woo , Lee Chang-Han , Park Wan Beom , Kim Hang-Rae , Oh Myoung-don 
Published: March 2022

BackgroundDespite the fact of ongoing worldwide vaccination programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), understanding longevity, breadth, and type of immune response to coronavirus disease-19 (COVID-19) is still important to optimize the vaccination strategy and estimate the risk of reinfection. Therefore, we performed thorough immunological assessments 1 year post-COVID-19 with different severity.MethodsWe analyzed peripheral blood mononuclear cells and plasma samples at 1 year post-COVID-19 in patients who experienced asymptomatic, mild, and severe illness to assess titers of various isotypes of antibodies (Abs) against SARS-CoV-2 antigens, phagocytic capability, and memory B- and T-cell responses.FindingsA total of 24 patients (7, 9, and 8 asymptomatic, mild, and severe patients, respectively) and eight healthy volunteers were included in this study. We firstly showed that disease severity is correlated with parameters of immune responses at 1 year post-COVID-19 that play an important role in protecting against reinfection with SARS-CoV-2, namely, the phagocytic capacity of Abs and memory B-cell responses.InterpretationVarious immune responses at 1 year post-COVID-19, particularly the phagocytic capacity and memory B-cell responses, were dependent on the severity of the prior COVID-19. Our data could provide a clue for a tailored vaccination strategy after natural infection according to the severity of COVID-19.
A Novel Laser Energy Ablation Catheter for Endocardial Cavo-Tricuspid Isthmus Ablation and Epicardial Ventricular Lesion Formation: An in vivo Proof-of-Concept Study
Authors: Krist Dennis , Linz Dominik , Schotten Ulrich , Zeemering Stef , Leenen Dwayne 
Published: March 2022

AimThis proof-of-concept study aimed to investigate atrial and ventricular lesion formation by a 20-mm linear laser ablation catheter, regarding lesion depth and tissue damage.MethodsIn total, 6 female swines underwent standard femoral vein access to introduce a novel 20-mm linear laser ablation catheter in the right atrium to perform endocardial cavotricuspid isthmus (CTI) ablations. The navigation took place under fluoroscopy with additional visualization by intracardiac echocardiograph. Via a sternotomy, epicardial ablations were performed on the surface of the left ventricle (LV), right ventricle (RV), and right atrial appendage (RAA). Procedural safety was assessed by registration of intraprocedural adverse events and by macroscopic examination of the excised hearts for the presence of charring or tissue disruption at the lesion site.ResultsAltogether 39 lesions were created, including 8 endocardial CTI (mean lesion length 20.6 ± 1.65 mm), 26 epicardial ventricle (mean lesion length LV: 25.3 ± 1.35 mm, RV: 24.9 ± 2.40 mm), and 5 epicardial appendage ablations (mean lesion length RAA: 26.0 ± 3.16 mm). Transmurality was achieved in all CTI and atrial appendage ablations, in 62% of the RV ablations and in none of the LV ablations. No perforation or steam pop occurred, and no animal died during the procedure.ConclusionIn this porcine study, the 20-mm linear laser ablation catheter has shown excellent results for endocardial cavotricuspid isthmus ablation, and it resulted in acceptable lesion depth during atrial and ventricular epicardial ablation. The absence of tissue charring, steam pops, or microbubbles under the experimental conditions suggests a high degree of procedural safety.
Increased Risk of Major Depressive Disorder Following Tinnitus: A Population-Based Study
Authors: Lin Herng-Ching , Xirasagar Sudha , Wang Chia-Hui , Cheng Yen-Fu , Yang Tzong-Hann 
Published: March 2022

Background and PurposeIn this study, we aimed to evaluate the relationship between tinnitus and a subsequent diagnosis of major depressive disorder (MDD) by studying the incidence of both entities.DesignA retrospective cohort study.MethodsData for this observational follow-up study were retrieved from the Taiwan's National Health Insurance Dataset. A total of 375,272 patients with newly diagnosed tinnitus (study group) were retrieved. The date of first diagnosis of tinnitus was assigned as their index date. Comparison patients were selected by propensity score matching (one per case, n = 375,272 controls) from the same dataset, with their index date being the date of their first health service claim in the year of diagnosis of their matched index case. We tracked each patient's claims records for 1 year from the index date to identify those who received a diagnosis of MDD. Cox proportional hazards regression was performed to calculate the MDD hazard ratio for cases vs. controls.ResultsWe found that the overall incidence rate for MDD was 0.78 (95% CI = 0.76~0.80) per 100 person-years, being 1.17 (95% CI = 1.14~1.21) among the study cohorts and 0.38 (95% CI = 0.36~0.40) among the comparison cohorts. The log-rank test revealed that the patients in the study cohort had significantly lower one-year MDD-free survival when compared to the comparison cohort (p &lt; 0.001). Cox proportional hazards analysis showed that the patients in the study cohort had a higher hazard of developing MDD than the patients in the comparison cohort (adjusted HR = 3.08, 95% CI = 2.90~3.27).ConclusionsIn this study, we demonstrate that tinnitus is associated with an increased hazard of subsequent MDD in Taiwan.
A Computational Tool for Three-Point Hitch Geometry Optimisation Based on Weight-Transfer Minimisation
Authors: Avello Fernández Lianet , Maraldi Mirko , Mattetti Michele , Varani Massimiliano 
Published: March 2022

The weight-transfer effect, consisting of the change in dynamic load distribution between the front and the rear tractor axles, is one of the most impairing phenomena for the performance, comfort, and safety of agricultural operations. Excessive weight transfer from the front to the rear tractor axle can occur during operation or manoeuvring of implements connected to the tractor through the three-point hitch (TPH). In this respect, an optimal design of the TPH can ensure better dynamic load distribution and ultimately improve operational performance, comfort, and safety. In this study, a computational tool (the Optimiser) for the determination of a TPH geometry which minimises the weight-transfer effect is developed. The Optimiser is based on a constrained minimisation algorithm. The objective function to be minimized is related to the tractor front-to-rear axle load transfer during a simulated reference manoeuvre performed with a reference implement on a reference soil. Simulations are based on a dynamic model of the tractor-TPH-implement aggregate. The geometry determined by the Optimiser complies with the ISO-730 Standard functional requirements and other design requirements. The interaction between the soil and the implement during the simulated reference manoeuvre was successfully validated against experimental data. The simulation results show that the adopted reference manoeuvre is effective in triggering the weight-transfer effect, with the front axle load exhibiting a peak-to-peak value of 27.1 kN during the manoeuvre. A benchmark test was conducted starting from the geometry of a commercially available TPH; the test showed that the Optimiser, after 36 iterations, was able to find an optimised TPH geometry which allows to reduce the weight-transfer effect by 14.9%.
Impact of Medication Reconciliation by a Dialysis Pharmacist
Authors: Dyer Summer A. , Nguyen Victoria , Rafie Sally , Awdishu Linda 
Published: March 2022

Key Points

Integrating a pharmacist into a hemodialysis unit significantly reduced medication discrepancies and medication-related problems over time.Medication reconciliation for the Centers for Medicare and Medicaid Services End-Stage Renal Disease Quality Incentive Program can be optimally performed by a dialysis pharmacist.
The psychologist’s diagnostic competences in issuing psychological and judicial opinions in divorce cases involving children
Authors: Pisarska Agnieszka 
Published: March 2022

Divorce cases where divorcing spouses have minor children pose a particular challenge for psychologists and lawyers. The court decides on important matters regarding the child and the family, but formally does not have sufficient knowledge of the psychological functioning of family members, and the decision is based on a psychological and judicial opinion. The psychologist does not make legally binding decisions regarding the family, but acts as an expert with so-called special information in selected areas of psychology, which allows preparing a psychological and judicial opinion on the functioning of the family to support the court’s decision-making process. Particular diagnostic competence of a psychologist: knowledge, skills and ethical attitude increase the likelihood of accurate and reliable psychological diagnosis and contribute to making the psychological and judicial opinion more useful to the court. The article presents selected legal and psychological issues related to the role of a psychologist and the process of diagnosing in providing psychological and judicial opinion on divorce matters where the partners are parents of minor children. It presents the psychologist’s diagnostic competences: (a) knowledge, including the knowledge of research areas important in making psychological diagnoses and specific issues (including the concept of resilience, parentification, parental alienation, the child’s adaptation, conflict between partners, the child’s best interest clause as a principle of family law, evidence-based diagnosis), basic legal principles on divorce, the status of an expert psychologist and psychological and judicial opinion, as well as other provisions which are not source of law in the form of guidelines and standards; (b) skills relating to effective planning and execution of multi-person diagnosis, the construction of the psychological and judicial opinion, the selection of diagnostic tools, the presentation of hypotheses, transparent and comprehensive data analysis and the formulation of conclusions; (c) an ethical attitude taking into account the special status of the psychologist and diagnostic relationship in divorce matters, taking into account ethical dilemmas and separateness of diagnosis conducted out of court.
Outcome Predictors of Tocilizumab Administration in Patients with Severe COVID-19
Authors: Теренин М.А. , Ялонецкий И.З. , Романова Е.В. 
Published: March 2022

В ретроспективном исследовании авторы попытались найти предикторы исхода у 100 пациентов с тяжелой формой COVID-19, получивших тоцилизумаб и проходивших лечение в отделении интенсивной терапии и реанимации. Все пациенты были разделены на 2 группы в зависимости от исхода заболевания (I группа – выжившие, II группа – умершие). Среди пациентов в возрасте до 60,5 года и с индексом коморбидности Чарлсона ≤2,5 балла прогнозировалась низкая вероятность летального исхода после введения тоцилизумаба. Пациенты, у которых до инфузии тоцилизумаба определялись ИЛ-6≤101 пг/мл, альбумин в крови ≥30,5 г/л и PaO2/FiO2≥125,5 мм рт. ст., относились к группе низкого риска летального исхода. Быстрое восстановление уровня лимфоцитов в крови со 2-х суток после инфузии тоцилизумаба может рассматриваться как предиктор благоприятного прогноза.
In a retrospective study, the authors attempted to find outcome predictors in 100 patients with severe COVID-19 who received Tocilizumab and were treated in the ICU. All patients were divided into 2 groups depending on the outcome of the disease (group I – survivors, group II – deceased). Among patients under the age of 60.5 years and with a Charlson comorbidity index ≤2.5 points, a low probability of death was predicted after the administration of Tocilizumab. Patients who had IL-6 ≤101 pg/ml, blood albumin ≥30.5 g/L, and PaO2/FiO2 ≥ 25.5 mm Hg before the Tocilizumab infusion were at low risk of mortality. The rapid recovery of blood lymphocyte levels from the 2nd day after tocilizumab infusion can be considered as a predictor of the favorable prognosis.
New Approaches to Treatment of Patients with Autoimmune Ophthalmopathy (the Review of the 2016 and 2021 Clinical Practice Guidelines of the European Group of Graves’ Orbitopathy (EUGOGO) for the Management of Graves’ Orbitopathy Endorsed by the European Society of Endocrinology (ESE))
Authors: Данилова Л.И. , Короленко Г.Г. 
Published: March 2022

Лечение аутоиммунной офтальмопатии (АИО) остается непростой задачей для клиницистов, требует пациентоориентированного подхода и анализа эффективности каждого этапа терапии. В обновленных рекомендациях четко прописан алгоритм лечения АИО с выделением терапии первого и второго уровня. Глюкокортикоиды остаются первой линией терапии. Значительный прорыв в понимании патогенеза АИО позволил активно использовать как уже известные, так и новые препараты антипролиферативного действия, биологическую терапию как вторую линию лечения при неудаче применения глюкокортикоидов. Возросло значение лучевой терапии на область орбит. Выделены приоритеты при лечении АИО и тиреотоксикоза в случае болезни Грейвса. Ознакомление эндокринологов и офтальмологов с представленными рекомендациями позволит улучшить результаты лечения пациентов с АИО и качество их жизни. С учетом новых трактовок механизмов развития АИО и практического опыта представляется целесообразным изменение протокола лечения АИО в Республике Беларусь.
The medical management of autoimmune ophthalmopathy (AIO) is a challenge for clinicians requiring a thoughtful analysis of each stage of treatment and considerable skill. Based on the accumulated experience, the AIO mamagement algorithm which provides thefirst- and the second-linetreatmentis clearly defined in the updated Guidelines. Due to their pathogenic validity, effectiveness and widespread availability, glucocorticoids have remained the first-line treatment. A major breakthrough in the understanding of AIO pathogenesis has allowed to actively usewell-establishedand new antiproliferative drugs andbiological agents as a second-line treatment if there is no response to glucocorticoids. The efficacy of orbital radiotherapy has increased. Priorities in the AIO management and treatment of thyrotoxicosis in Graves’ disease are highlighted. Endocrinologists’ and ophthalmologists’awareness of the updated Guidelines will significantly improve the treatment outcomes in patients with AIO and their quality of life. Taking into account the new insights into the pathogenesis of AIO and clinical experience, it seems appropriate to amend the protocol for the medicalmanagement of AIO in the Republic of Belarus.