bluuebunny/crossref_metadata_2025_split huggingface dataset:
Client and staff perceptions of the integration of trauma informed care and specialist posttraumatic stress disorder treatment in residential treatment facilities for substance use: A qualitative study
Authors: Mefodeva Valeriya , Carlyle Molly , Walter Zoe , Hides Leanne 
Published: September 2022

AbstractIntroductionComorbid posttraumatic stress disorder (PTSD) is prevalent among people seeking residential treatment for substance use disorders (SUD). We examined client and staff perceptions of the relationship between trauma and SUDs, and the integration of trauma‐informed care (TIC) and specialist‐delivered treatment for PTSD in residential alcohol and other drug (AOD) treatment facilities.MethodsIndividual semi‐structured interviews were conducted with frontline staff (n = 20) and clients (n = 18) in two residential AOD treatment facilities in Queensland, Australia. Interviews were audio recorded, transcribed and shared client and staff data was analysed using thematic analysis.ResultsMajor staff and client themes emerged: PTSD was perceived as an underlying cause of SUD, where AOD is used to cope with and avoid PTSD and related symptoms (Theme 1). Residential facilities were perceived to provide a safe and supportive environment for clients (Theme 2). Psychoeducation on SUD and PTSD was also highlighted to normalise experiences associated with comorbid SUD/PTSD and promote help‐seeking pathways for specialist PTSD treatment. Concurrent treatment of SUD and PTSD in the residential setting was sought after and was perceived to enhance treatment outcomes (Theme 3). Staff saw the need for implementing TIC into the organisation and perceived TIC as a multi‐faceted and consistent approach of service delivery.Discussion and ConclusionsBoth clients and staff perceive comorbid SUD/PTSD as a challenge in residential treatment, that may be overcome through integrating TIC and PTSD treatment in residential treatment facilitates for substance use. Organisational and practical implications are discussed.
Role of the SEC62 gene in dermato‐oncology – impact on tumor cell biology, prognostication, and personalized therapy management
Authors: Linxweiler Maximilian , Müller Cornelia S. L. 
Published: September 2022

SummaryThe SEC62 gene encodes for a transmembrane protein of the endoplasmic reticulum (ER). Sec62 protein is involved in the post‐translational transport of secretory and membrane‐bound proteins in eukaryotic cells, regulates intracellular calcium homeostasis through direct interaction with the Sec61 channel and makes a decisive contribution to the cellular compensation of ER stress in the context of recovER‐phagy. A significantly increased expression of the SEC62 gene has already been demonstrated in various tumor entities. First approaches of a targeted therapy have been tested for various tumor entities in vitro and in vivo with promising results that motivate further preclinical and clinical studies. Nevertheless, many questions remain unanswered, in particular with regard to the molecular mechanisms underlying the observed clinical effects, and require further investigation in future studies. The protein also plays a relevant role in dermato‐oncology. The overexpression of SEC62 in atypical fibroxanthomas and malignant melanomas has already been demonstrated and a correlation of SEC62 expression with various clinical and pathological features has been observed. Future studies, especially in vivo and clinical, will show whether Sec62 can be established as a prognostic marker in dermato‐oncology and whether it can serve as a starting point for targeted therapy.
Conditioning with melphalan 200 mg/m2 and subsequent ASCT improves progression‐free and overall survival in elderly myeloma patients compared to standard of care
Authors: Afram Gabriel , Chaireti Roza , Uttervall Katarina , Luong Vincent , Lund Johan , Kashif Muhammad , Gahrton Gösta , Alici Evren , Nahi Hareth 
Published: September 2022

AbstractObjectivesDespite the effectiveness of newer drugs for the treatment of multiple myeloma (MM), the outcomes are further improved by subsequent autologous stem cell transplantation (ASCT). Data on effectiveness in older patients are limited. We compared outcomes in patients aged 65–75 years depending on whether they were treated with ASCT or not and compared those to outcomes in patients <65 years.MethodsThis was a retrospective, single‐center study. We compared progression‐free survival (PFS) and overall survival (OS) for all MM patients below and above the age of 65 years treated ± ASCT at the Karolinska University Hospital between 2010 and 2020. PFS and OS were calculated by the Kaplan–Meier method. Variables affecting PFS and OS were evaluated using Cox regression model.ResultsBoth PFS and OS were improved in the group 65–75 years treated +ASCT compared to those treated pharmacologically (p = 0.008 and p < 0.001, respectively). There were no significant differences between patients <65 years and those 65–75 years treated with ASCT.ConclusionThe findings indicate that even patients >65 years should be evaluated as candidates for ASCT. An individualized approach supported by a frailty/geriatric assessment score could assist clinicians to select the appropriate treatment for each patient.
Credit variance risk premiums
Authors: Ammann Manuel , Moerke Mathis 
Published: September 2022

AbstractThis paper studies variance risk premiums in the credit market using a novel data set of swaptions quotes on the CDX North America Investment Grade and High‐Yield indices. The returns of credit variance swaps are negative and economically large, irrespective of the credit rating class. They are robust to transaction costs and cannot be explained by established risk factors and structural model variables. We also dissect the overall variance risk premium into receiver and payer variance risk premiums. We show that credit variance risk premiums are mainly driven by the payer corridor, which is associated with worsening macroeconomic conditions.
Tracking dietary fatty acids in triacylglycerols and phospholipids of zooplankton
Authors: Mathieu Francine , Guo Fen , Kainz Martin J. 
Published: September 2022

Abstract

Fatty acids (FA) in lake zooplankton are largely provided by dietary FA and affected by taxonomic composition of zooplankton, temperature, and other environmental conditions. However, the extent to which dietary FA are retained and/or bioconverted in zooplankton remains unclear. In this lake study, we examined how dietary FA (seston), temperature and physico‐chemical variables (i.e., concentrations of chlorophyll a, dissolved organic carbon, nitrate, ammonium, phosphate) explained the FA variation in membrane (phospholipids; PL) and storage (triacylglycerols; TAG) lipids of zooplankton.

We tested the hypotheses that: (1) increasing dietary FA increases the FA content stored as TAG by zooplankton, whereas the FA content in PL remains unaffected by naturally occurring changes in dietary FA supply; and (2) FA in seston better predict the FA variations stored by zooplankton as TAG, whereas lake temperature better predicts the FA variations in zooplankton PL.

Results show that an increase in dietary polyunsaturated FA increased polyunsaturated FA in TAG and PL of zooplankton, but not eicosapentaenoic acid or docosahexaenoic acid in PL. Moreover, the FA content of seston was more similar to that of zooplankton TAG than it was to the content of PL, indicating major taxon‐specific differences in membrane FA.

Dietary FA are a major predictor of FA in TAG of zooplankton, while the taxonomic composition of zooplankton is a major predictor of FA in PL. Temperature and physico‐chemical variables explained little of the variations in zooplankton FA. This field study improves our understanding of how FA in PL and TAG of different zooplankton taxa respond to changes of dietary FA, temperature, concentrations of chlorophyll‐a, dissolved organic carbon, nitrate, ammonium, and phosphate to fulfil their physiological requirements.
Efficacy of adding chemical and microbial additives to silage on beef cattle performance: Systematic review and meta‐analysis
Authors: Menezes Guilherme Lobato , de Oliveira Alan Figueiredo , de Assis Pires Frederico Patrus Ananias , Gonçalves Lúcio Carlos , de Menezes Rafael Araújo , de Sousa Pamella Grossi , de Medeiros Paulo Henrique Arruda , de Pinho Matheus Morais , Lana Ângela Maria Quintão , de Araújo Vânia Eloisa , Jayme Diogo Gonzaga 
Published: September 2022

AbstractThe effects of different additives on farm‐scale silage quality and beef cattle performance are inconsistent. This study aimed to carry out a systematic review and meta‐analysis to evaluate the efficacy of chemical and microbial additives to silage on beef cattle performance. Systematic searches were performed using databases and scientific journals, and 42 articles were selected. Data for all variables were grouped into subgroups according to the additive type. For dry matter intake and average daily gain, the data were also grouped by forage type due to greater comparison numbers. The treatment mean differences and 95% confidence intervals (p < 0.05) were analysed using a random‐effects model. The use of homo‐ and heterofermentative microbial inoculant mixtures and chemical additives (Ch) increased the average daily gain of beef cattle fed maize/sorghum silage. Homofermentative microbial inoculant (Ho), Ch, and a mixture of microbial inoculant and chemical additives also increased the average daily gain of beef cattle fed temperate grasses. Only Ch increased dry matter intake. Ch increased feed efficiency, and Ch and Ho increased carcass weight. The evaluated additives improved the silage fermentation process mainly via pH and ammonia nitrogen reduction. Overall, this meta‐analysis demonstrated that silage additives improved the ensiling process and beef cattle performance, with better results with Ch use. Due to the aerobic stability and microbiological profile analyses being carried out more in laboratory‐scale silos, more studies are needed to determine these silage parameters after opening the silo at the farm scale.
Analysis of pulmonary nodules detected by annual low‐dose computed tomography in the elderly during a 10‐year follow‐up
Authors: Liu Zhonghui , Liu Xinmin , Ni Lianfang 
Published: September 2022

AimTo describe pulmonary nodules detected by annual low‐dose computed tomography (LDCT) in the elderly during a 10‐year follow‐up, and to provide a basis for clinical decision‐making in the elderly.MethodsIn this retrospective study, patients who completed at least a 3‐year follow‐up visit with annual LDCT imaging data were eligible for inclusion. The evolution of pulmonary nodules was evaluated, including malignant, suspicious malignant, benign and undetermined nodules. Additionally, the nature and outcome of new nodules during the follow‐up were analyzed.ResultsFor the 365 subjects included, 899 positive pulmonary nodules were detected in 286 patients. Among these there were 788 solid nodules, 20 part‐solid nodules and 91 nonsolid nodules. The detection rate of positive nodules and of lung cancer was 78.4% and 5.5%, respectively. 99.7% (786/788) of solid nodules were benign, and 75% (15/20) of part‐solid nodules and 28.6% (26/91) of nonsolid nodules were malignant or suspected malignant. 124 new positive nodules appeared during the annual follow‐up, but 58.9% of them subsequently disappeared. Significant higher detection rates of 10–20‐mm nodules (P = 0.0485) and suspicious malignant nodules (P = 0.017) were observed in subjects over 75 years old as compared with those under 75 years old.ConclusionsSolid nodules accounted for the highest proportion of lung nodules screened at baseline, and most of them were benign. The malignant probability of part‐solid nodules was the highest. Most newly appeared nodules disappeared during subsequent follow‐up. The proportions of suspicious malignant nodules and 10–20‐mm nodules in subjects over 75 years old were higher than in those under 75 years old. Geriatr Gerontol Int 2022; 22: 865–869.
Reference intervals for erythrocyte parameters and hemoglobin electrophoresis parameters for young children in Guangxi
Authors: Zhou Chaofan , He Sheng , Liu Dun , Zuo Yangjin , Chen Qiuli , Wang Liang , Chen Biyan , Chen Faqin , Luo Jingsi , Xu Xiangmin , Lin Li 
Published: September 2022

AbstractBackgroundErythrocyte parameter analysis is the important means for diagnosis and treatment of hematological diseases, which are essential for screening of thalassemia in southern China combined with hemoglobin electrophoresis analysis. But little is known regarding the reference intervals (RIs) in healthy pediatrics in these two areas.Methods95% RIs of erythrocyte parameters were calculated from 853 healthy preschoolers, aged from 1 days to <6 years, according to the C28‐A3C guidelines of the Institute of Clinical and Laboratory Standards. To express the magnitude of sex and age variation, standard deviation ratio (SDR) was calculated using ANOVA. Concurrently, we selected 3814 thalassemia carriers as carriers group and drew receiver operating characteristic (ROC) curves to establish the optimal cut‐off values of hemoglobin electrophoresis parameters, which were used as the upper/lower limits of RIs to efficiently screen thalassemia.ResultsAll parameters except red blood cell (RBC) required age partitioning, confirmed by SDRage above .4. There was no need for sex partitioning on all parameters, confirmed by SDRsex below .4. The optimal cut‐off value of Hemoglobin A2 (Hb A2) in the four subgroups was <7.8% (Hb A), 2.3%–3.2%, 2.5%–3.6% and 2.6%–3.6%, respectively.ConclusionIn this study, the establishment of RIs improved the diagnostic efficiency of hematological disease (especially thalassaemia) for children in Guangxi. It provides reliable hematological references for the identification and diagnosis, treatment monitoring, and health screening of children's clinical diseases.
Computing efficiently the nondominated subset of a set sum
Authors: Kerbérénès Antoine , Vanderpooten Daniel , Vanpeperstraete Jean‐Michel 
Published: September 2022

AbstractWe study the computation of the nondominated subset of the Minkowski sum (or set sum) of a finite family of finite sets of multidimensional, real‐valued points. When points are the images of solutions to multiobjective optimization problems, this computation is a key algorithmic component for solving coupled systems problems. At first sight, this computation may be thought of as computing all combinations of points and applying dominance filtering to the resulting set of points. However, structural properties can be exploited algorithmically to perform this task more efficiently, avoiding some comparisons. We propose two main approaches of doing so. First, we show that using lexicographic ordering over each set to be added to the sum, we can speed up the sorting phase required to efficiently apply dominance filtering to elements of the set sum. Second, we introduce box‐based methods, defining dominance relations between sets of combinations of points.
Implementing a bivariate ordering and replacement policy for deteriorating systems with two failure types
Authors: Dong Wenjie , Du Junliang , Yang Mengyue , Liu Sifeng 
Published: September 2022

AbstractFor plenty of existing maintenance policies in literature, it is always assumed that the spare unit for replacement is available at any time if needed, while this perquisite may be unrealistic or even impossible. In this paper, we investigate an ordering and replacement modeling framework for a deteriorating repairable system with two failure types, involving a repairable failure (Type I failure) and a nonrepairable failure (Type II failure). A regular order and an expedited order are both incorporated into the spare unit ordering policy while a preventive replacement and a corrective replacement are both considered into the replacement policy, of which the ordering and replacement policy is scheduled in regard to the number of repairable failures. The expected profit per unit of time over an infinite time span is maximized to seek the optimal solutions in terms of the renewal reward theorem with a recursive algorithm procedure. An illustrative example is designed to validate the applicability and effectiveness of the developed ordering and replacement policy. In addition, the sensitivity of the optimal ordering‐replacement policy is studied and the effect of some key characteristics on the optimal decisions is discussed.
The comparison between experimental nursing and routine nursing interventions on the quality of life of stoma patients: A systematic review and meta‐analysis
Authors: Guo Yanyan , Zhang Yuanyuan , Guo Xianzhen , Zhao Wenting , Wang Qiuyan , Liu Xinxin , Li Shuang , Che Jinze , Zhou Ti 
Published: September 2022

AbstractThe advance in nursing care for stoma patients is a challenging issue, which will influence the life quality. The quality of life is a major issue in the recovery of stoma patients. The evidence of experimental nursing has not been explored enough. A systematic search and a meta‐analysis were performed for the studies of experimental nursing interventions versus routine warming interventions on patients with a stoma. The comparisons between nursing interventions were performed to find which kind of intervention will be superior in improving life quality. After a restricted selection, 10 studies, 460 subjects with experimental nursing intervention, and 478 controls with the routine nursing intervention were enrolled in a variety of causes of the stoma. The focused outcome was the quality of life. The meta‐analysis was performed by Review Manager 5.4. Among the stoma patients, the meta‐analysis favours the experimental nursing intervention group with higher scores of life quality when compared to the routine nursing intervention group. The meta‐analysis results were with positive mean differences, significant tests for overall effect, and significant heterogeneities in the random‐effects model. The experimental nursing intervention showed higher positive effects on the quality of life when compared to routine nursing intervention for stoma patients. Experimental nursing intervention might be an option for stoma nursing practitioners to improve stoma care.
Rapid pruritus reduction with ruxolitinib cream treatment in patients with atopic dermatitis
Authors: Blauvelt Andrew , Kircik Leon , Papp Kim A. , Simpson Eric L. , Silverberg Jonathan I. , Kim Brian S. , Kwatra Shawn G. , Kuligowski Michael E. , Venturanza May E. , Wei Shaoceng , Szepietowski Jacek C. 
Published: September 2022

AbstractBackgroundRuxolitinib cream is a topical formulation of ruxolitinib, a Janus kinase (JAK) 1/JAK2 inhibitor.ObjectivesTo report timing and magnitude of effect of ruxolitinib cream on itch in patients with atopic dermatitis (AD), a highly pruritic inflammatory skin disease.MethodsTwo phase 3 trials (TRuE‐AD1 [NCT03745638]/TRuE‐AD2 [NCT03745651]) enrolled patients aged ≥12 years with AD for ≥2 years, Investigator's Global Assessment score of 2 or 3, and 3%–20% affected body surface area. Patients (total N = 1249; median age, 32 years) were randomised (2:2:1) to twice daily 0.75% ruxolitinib cream, 1.5% ruxolitinib cream or vehicle cream for 8 weeks of double‐blinded treatment. Worst itch was measured using the numerical rating scale (NRS).ResultsSignificantly more patients who applied ruxolitinib cream (either strength) achieved a ≥2‐point itch reduction (NRS2) within approximately 12 h versus vehicle (0.75%/1.5% ruxolitinib cream, 16.3%/13.1%; vehicle, 6.9%; both P < 0.05), with further improvements through Week 8 (58.3%/65.1% vs 29.4%; both P < 0.0001). A ≥4‐point itch reduction (NRS4) was achieved by significantly more patients who applied 0.75%/1.5% ruxolitinib cream versus vehicle by Day 2 (8.9%/11.2% vs 2.1%; P < 0.005); higher rates were observed at Week 8 (41.5%/51.5% vs 15.8%; P < 0.0001). Median time for the 0.75%/1.5% ruxolitinib cream groups to achieve NRS4 from baseline was 15.0/13.0 days; this endpoint was not reached by the vehicle group.ConclusionsRuxolitinib cream demonstrated rapid improvement in itch in patients with mild to moderate AD that was sustained for 8 weeks. Significantly more patients applying ruxolitinib cream achieved itch NRS2 within approximately 12 h and itch NRS4 by Day 2 versus vehicle.
Sicyopterus garra Hora, 1925, a valid species of sicydiine goby from the Andaman Islands, India
Authors: Praveenraj Jayasimhan , Kiruba‐Sankar Rajendran , Saravanan Kandasamy , Thackeray Tejas , Singh Pratima , Knight John Daniel Marcus , Keith Philippe 
Published: September 2022

AbstractSicyopterus garra Hora, 1925 from the insular streams of South Andaman Islands was synonymized with Sicyopterus microcephalus described from Java, South East Asia and has retained this taxonomic status since then. Recent collections of Sicyopterus from the type locality of S. garra and the examination of syntypes of this species revealed significant morphological and genetic differences from S. microcephalus and the other Sicyopterus species with papillae on upper lip. S. garra is thus a valid species and not a synonym of S. microcephalus. S. garra differs from S. microcephalus in having fewer lateral scales 53–59 vs. 57–68, fewer zigzag series (12–14 vs. 13–16), a longer caudal peduncle length (16–21 vs. 13–17), and by having a high percentage of divergence in COI gene (5.5%–5.8%).
METTL3 contributes to slow transit constipation by regulating miR‐30b‐5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8
Authors: Gong Wen‐jing , Li Rong , Dai Qiao‐qiong , Yu Peng 
Published: September 2022

AbstractBackgroundN6‐methyladenosine (m6A) is the most prevalent methylation modification of eukaryotic RNA, and methyltransferase‐like 3 (METTL3) plays a vital role in multiple cell functions. This study aimed to investigate the role of m6A methylase METTL3 in slow transit constipation (STC).Material and MethodThe expression of METTL3 and DGCR8 was measured in STC tissues and glutamic acid‐induced interstitial cells of Cajal (ICCs). The effects of METTL3, miR‐30b‐5p, and DGCR8 on the biological characteristics of ICCs were investigated on the basis of loss‐of‐function analyses. Luciferase reporter assay was used to identify the direct binding sites of miR‐30b‐5p with PIK3R2.ResultsThe results showed that the METTL3, DGCR8, miR‐30b‐5p, and the methylation level of m6A were significantly increased in STC tissues and glutamic acid‐induced ICCs. Silencing of METTL3 and miR‐30b‐5p inhibited apoptosis, autophagy, and pyroptosis of glutamic acid‐induced ICCs. Moreover, overexpression of miR‐30b‐5p reversed the cytoprotection of METTL3 knockdown in glutamic acid‐induced ICCs. Besides, DGCR8 knockdown could facilitate cell growth and decrease apoptotic glutamic acid‐induced ICCs. Mechanically, we illustrated that METTL3 in glutamic acid‐induced ICCs significantly accelerated the maturation of pri‐miR‐30b‐5p by m6A methylation modification, resulting in the reduction of PIK3R2, which results in the inhibition of PI3K/Akt/mTOR pathway and ultimately leads to the cell death of STC.ConclusionsCollectively, these data demonstrated that METTL3 promoted the apoptosis, autophagy, and pyroptosis of glutamic acid‐induced ICCs by interacting with the DGCR8 and successively modulating the miR‐30b‐5p/PIK3R2 axis in an m6A‐dependent manner, and METTL3 may be a potential therapeutic target for STC.