bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of prophylactic mesh implantation on the development of incisional hernias in patients with elevated BMI: a systematic review and meta-analysis
Authors: Pianka F. , Werba A. , Klotz R. , Schuh F. , Kalkum E. , Probst P. , Ramouz A. , Khajeh E. , Büchler M. W. , Harnoss J. C. 
Published: September 2022

Abstract
Background
Incisional hernia is a common complication after midline laparotomy. In certain risk profiles incidences can reach up to 70%. Large RCTs showed a positive effect of prophylactic mesh reinforcement (PMR) in high-risk populations.

Objectives
The aim was to evaluate the effect of prophylactic mesh reinforcement on incisional hernia reduction in obese patients after midline laparotomies.

Methods
Following the PRISMA guidelines, a systematic literature search in Medline, Web of Science and CENTRAL was conducted. RCTs investigating PMR in patients with a BMI ≥ 27 reporting incisional hernia as primary outcome were included. Study quality was assessed using the Cochrane risk-of-bias tool and certainty of evidence was rated according to the GRADE Working Group grading of evidence. A random-effects model was used for the meta-analysis. Secondary outcomes included postoperative complications.

Results
Out of 2298 articles found by a systematic literature search, five RCTs with 1136 patients were included. There was no significant difference in the incidence of incisional hernia when comparing PMR with primary suture (odds ratio (OR) 0.59, 95% CI 0.34–1.01, p = 0.06, GRADE: low). Meta-analyses of seroma formation (OR 1.62, 95% CI 0.72–3.65; p = 0.24, GRADE: low) and surgical site infections (OR 1.52, 95% CI 0.72–3.22, p = 0.28, GRADE: moderate) showed no significant differences as well as subgroup analyses for BMI ≥ 40 and length of stay.

Conclusions
We did not observe a significant reduction of the incidence of incisional hernia with prophylactic mesh reinforcement used in patients with elevated BMI. These results stand in contrast to the current recommendation for hernia prevention in obese patients.
A Thermal-Solid–Fluid Method for Topology Optimization of Structures with Design-Dependent Pressure Load
Authors: Huang Huixin , Hu Jingyu , Liu Shutian , Liu Yang 
Published: September 2022

AbstractFor the topology optimization of structures with design-dependent pressure, an intuitive way is to directly describe the loading boundary of the structure, and then update the load on it. However, boundary recognition is usually cumbersome and inaccurate. Furthermore, the pressure is always loaded either outside or inside the structure, instead of both. Hence, the inner enclosed and outer open spaces should be distinguished to recognize the loading surfaces. To handle the above issues, a thermal-solid–fluid method for topology optimization with design-dependent pressure load is proposed in this paper. In this method, the specific void phase is defined to be an incompressible hydrostatic fluid, through which the pressure load can be transferred without any needs for special loading surface recognition. The nonlinear-virtual thermal method (N-VTM) is used to distinguish the enclosed and open voids by the temperature difference between the enclosed (with higher temperature) and open (with lower temperature) voids, where the solid areas are treated as the thermal insulation material, and other areas are filled with the self-heating highly thermally conductive material. The mixed displacement–pressure formulation is used to model this solid–fluid problem. The method is easily implemented in the standard density approach and its effectiveness is verified and illustrated by several typical examples at the end of the paper.
Repair of critical diaphyseal defects of lower limbs by 3D printed porous Ti6Al4V scaffolds without additional bone grafting: a prospective clinical study
Authors: Liu Bingchuan , Hou Guojin , Yang Zhongwei , Li Xingcai , Zheng Yufeng , Wen Peng , Liu Zhongjun , Zhou Fang , Tian Yun 
Published: September 2022

AbstractThe repair of critical diaphyseal defects of lower weight-bearing limbs is an intractable problem in clinical practice. From December 2017, we prospectively applied 3D printed porous Ti6Al4V scaffolds to reconstruct this kind of bone defect. All patients experienced a two-stage surgical process, including thorough debridement and scaffold implantation. With an average follow-up of 23.0 months, ten patients with 11 parts of bone defects were enrolled in this study. The case series included three females and seven males, their defect reasons included seven parts of osteomyelitis and four parts of aseptic nonunion. The bone defects located at femur (five parts) and tibia (six parts), with an average defect distance of 12.2 cm. Serial postoperative radiologic follow-ups displayed a continuous process of new bone growing and remodeling around the scaffold. One patient suffered tibial varus deformity, and he underwent a revision surgery. The other nine patients achieved scaffold stability. No scaffold breakage occurred. In conclusion, the implantation of 3D printed Ti6Al4V scaffold was feasible and effective to reconstruct critical bone defects of lower limbs without additional bone grafting.
How do Gambling Providers Use the Social Network Twitter in Germany? An Explorative Mixed-Methods Topic Modeling Approach
Authors: Singer Johannes , Kufenko Vadim , Wöhr Andrea , Wuketich Marius , Otterbach Steffen 
Published: September 2022

AbstractThis study examines the social media activities of gambling providers in Germany, focusing on the platform Twitter. A collection of 34.151 tweets from 13 Twitter accounts was made, representing casinos, sports betting, state lotteries, social lotteries and lottery brokers. We apply an explorative mixed-methods approach, integrating a summative content analysis together with a semi-supervised guided topic modeling approach, to analyse frequency, number of followers, interaction and content of Twitter messages, and work out differences among the individual providers. The results show that Twitter does not seem to be particularly important for gambling providers who are active in Germany. Regarding outreach, frequency of tweets and interaction, Twitter plays a much smaller role than, for example, in the UK. The potential for Twitter to be an advertising, marketing and interaction channel has not yet been fully exploited, which would make it a perfect moment for developing an appropriate regulatory framework. Overall, the results of semi-supervised topic modeling show that providers most often use informative content (news) and combine it with other, usually less neutral content. It is alarming that many providers make little or no use of Responsible Gambling messages. Even though the activities are presently on a low level, they contribute to the normalization of gambling, setting incentives for increasing gambling participation. Children and youth form a large segment of Twitter users. Potential harm can arise especially for this group because of the lack of enforcement of any age limit.
Surgical results of 158 petroclival meningiomas with special focus on standard craniotomies
Authors: Schackert Gabriele , Lenk Miriam , Kirsch Matthias , Hennig Silke , Daubner Dirk , Engellandt Kay , Appold Steffen , Podlesek Dino , Sandi-Gahun Sahr , Juratli Tareq A. 
Published: September 2022

Abstract
Objective
The goal of this retrospective study is the evaluation of risk factors for postoperative neurological deficits after petroclival meningioma (PCM) surgery with special focus on standard craniotomies.

Materials and methods
One-hundred-fifty-eight patients were included in the study, of which 133 patients suffered from primary and 25 from recurrent PCM. All patients were operated on and evaluated concerning age, tumor size, histology, pre- and postoperative cranial nerve (CN) deficits, morbidity, mortality, and surgical complications. Tumor-specific features—e.g., consistency, surface, arachnoid cleavage, and location—were set in a four-grade classification system that was used to evaluate the risk of CN deficits and tumor resectability.

Results
After primary tumor resection, new CN deficits occurred in 27.3% of patients. Preoperative ataxia improved in 25%, whereas 10% developed new ataxia. Gross total resection (GTR) was achieved in 59.4%. The morbidity rate, including hemiparesis, shunt-dependence, postop-hemorrhage, and tracheostomy was 22.6% and the mortality rate was 2.3%. In recurrent PCM surgery, CN deficits occurred in 16%. GTR could be achieved in three cases. Minor complications occurred in 20%. By applying the proposed new classification system to patients operated via standard craniotomies, the best outcome was observed in type I tumor patients (soft tumor consistency, smooth surface, plane arachnoid cleavage, and unilateral localization) with GTR in 78.7% (p < 0.001) and 11.9% new CN deficits (p = 0.006).

Conclusion
Standard craniotomies as the retrosigmoid or subtemporal/pterional approaches are often used for the resection of PCMs. Whether these approaches are sufficient for GTR—and avoidance of new neurological deficits—depends mainly on the localization and intrinsic tumor-specific features.
Photosynthetic patterns during autumn in three different Salix cultivars grown on a brownfield site
Authors: Palm Emily , Guidi Nissim Werther , Gagnon-Fee Daphné , Labrecque Michel 
Published: September 2022

AbstractLeaf senescence at the end of the growing season is a complex process stimulated by changes in daylength and temperature that prepares deciduous trees for winter by reducing photosynthetic rates and remobilization of nutrients. Extending the duration of photosynthetic activity could have important consequences for the translocation of heavy metals in the phytoremediation of contaminated sites using deciduous trees like willow. In the present study, three Salix cultivars (‘India,’ ‘SX67,’ and ‘Fish Creek’) that were observed to maintain green leaves late into autumn were evaluated over an 11-week period extending from mid-September to mid-November on a brownfield site in Montreal, Canada. Gas exchange rates, chlorophyll fluorescence, and leaf pigments were measured weekly. A general trend of declining stomatal conductance and transpiration were observed early in the trial, followed by reductions in photosynthetic efficiency and concentrations of chl a, chl b, and carotenoids, in agreement with other studies. In particular, the cultivar ‘Fish Creek’ had higher rates of gas exchange and pigment concentrations than either ‘SX67’ or ‘India,’ but values for these parameters also declined more rapidly over the course of the trial. Both photoperiod and soil and air temperatures were strong drivers of changes in photosynthetic activity in all three of these cultivars according to correlation analyses. Further studies should focus on their biomass production and heavy metal accumulation capacity in light of the observed variation in photosynthetic activity stimulated by seasonal changes in light and temperature.
The dawn and rise of antimony use in the southern Caucasus
Authors: Dillis Sarah , Degryse Patrick 
Published: September 2022

AbstractAntimony (Sb) was utilised over several millennia as the prime material to opacify or decolour glass and glazes, as well as an accompanying element in copper (Cu) alloys. Metallic antimony objects are rare, and mostly confined to Chalcolithic Central Italy and to the first millennia BCE in the southern Caucasus. The innovation of antimony use in metallurgy seems to be confined to the southern Caucasus, and the invention of it might be even more specifically situated in the Great Caucasus. Preexisting knowledge of mining set the pathway for the initial stage of antimonial copper alloys in the first half of the third millennium BCE and for metallic antimony ornaments in the second half of the third millennium BCE. However, the first major expansion of antimony in the metallurgy of the Racha-Lechkumi district in the southern Caucasus (present-day Georgia) started around 1700 BCE, while its spreading in glassmaking occurred in the Late Bronze Age (LBA). Explanations that place antimony adoption within its broader social context are favoured over those that consider material or geological properties in isolation. A recurring theme is the importance of comparative analysis, both geographically and between the different pyrotechnologies, including the precious metals and glass industries, to explore how social, political, climatic and economic conditions affected adoption and innovation patterns. All these factors are considered to explain why the extraction of antimony blossomed in the Late Bronze Age in the southern Caucasus and to reconstruct a framework of exploitation, distribution/trade and use of antimony in the Caucasus and its neighbouring regions in the south and east.
Outcomes of lung cancer surgery in patients with COVID-19 history: a single center cohort study
Authors: Gabryel Piotr , Zielińska Dominika , Skrzypczak Piotr , Sielewicz Magdalena , Campisi Alessio , Kasprzyk Mariusz , Piwkowski Cezary 
Published: September 2022

Abstract
Objectives
Coronavirus disease 2019 (COVID-19) can irreversibly damage the lungs and could possibly increase the risk of surgical treatment of lung cancer. The study aimed to assess the relationship between preoperative COVID-19 and complications and early outcomes of lung cancer surgery.

Methods
This single-center cohort study included 444 patients who underwent lobectomy or segmentectomy for primary lung cancer from January 1, 2019 to December 31, 2021. The exclusion criteria were pneumonectomy, extended resection, and wedge resection. The groups of patients with (n = 72) and without (n = 372) the history of COVID-19 prior to surgery were compared. The groups were similar in terms of distribution of baseline, surgical and histopathological characteristics. The primary endpoint was the incidence of postoperative complications. Secondary endpoints were outcomes at discharge and at 90 days.

Results
The incidence of postoperative complications did not differ between the groups of patients with and without COVID-19 history (30.6% vs 29.3%, p = 0.831). Outcomes at discharge and at 90 days after surgery did not differ between the groups. Among the patients with and without prior COVID-19, 97.2 and 99.5% were alive at discharge (p = 0.125), and 97.2% and 98.1% ninety days after surgery (p = 0.644), respectively. Patients with COVID-19 history more often required re-drainage (6.9% v 2.2%, p = 0.044) and reoperation (5.6 v 1.3%, p = 0.042).

Conclusions
COVID-19 history is not related to the general incidence of complications, outcomes at discharge from the hospital, and at 90-days after surgery.
Utilization of Receptor-Binding Domain of SARS-CoV-2 Spike Protein Expressed in Escherichia coli for the Development of Neutralizing Antibody Assay
Authors: Tantiwiwat Termsak , Thaiprayoon Apisitt , Siriatcharanon Ake-kavitch , Tachaapaikoon Chakrit , Plongthongkum Nongluk , Waraho-Zhmayev Dujduan 
Published: September 2022

AbstractThe ongoing COVID-19 pandemic has resulted from widespread infection by the SARS-CoV-2 virus. As new variants of concern continue to emerge, understanding the correlation between the level of neutralizing antibodies (NAb) and clinical protection from SAR-CoV-2 infection could be critical in planning the next steps in COVID-19 vaccine programs. This study explored the potential usefulness of E. coli as an alternative expression system that can be used to produce a SARS-CoV-2 receptor-binding domain (RBD) for the development of an affordable and flexible NAb detection assay. We expressed the RBD of Beta, Delta, and Omicron variants in the E. coli BL21(DE3) strain and purified them from whole bacterial cells using His-tag-mediated affinity chromatography and urea-assisted refolding. Next, we conducted a head-to-head comparison of the binding activity of our E. coli-produced RBD (E-RBD) with commercial HEK293-produced RBD (H-RBD). The results of a direct binding assay revealed E-RBD and H-RBD binding with ACE2-hFc in similar signal strengths. Furthermore, in the NAb detection assay, % inhibition obtained from both E-RBD and H-RBD demonstrated comparable results in all the investigated assays, suggesting that non-glycosylated RBD produced from E. coli may offer a cost-effective alternative to the use of more expensive glycosylated RBD produced from human cells in the development of such an assay.
Het mannelijk bekken en de mannelijke bekkenfysiotherapeut
Authors: van der Heide Carel Jan , Gianotten Woet L. 
Published: September 2022

SamenvattingIn de afgelopen decennia heeft de bekkenfysiotherapie zich zowel in Nederland als in het buitenland ontwikkeld tot een vakgebied dat voornamelijk wordt beoefend door vrouwelijke fysiotherapeuten en met vooral aandacht voor het vrouwelijke bekken. Dit artikel draagt drie belangrijke argumenten aan om deze situatie te veranderen: 1) mannelijke fysiotherapeuten zijn hard nodig bij het personeelstekort in de bekkenfysiotherapie, 2) zonder mannelijke bekkenfysiotherapeuten kan de patiënt niet vrij kiezen, hetgeen relevant is in de context van schaamte, beladenheid en seksueel misbruik, en 3) er is een grote kennisachterstand rond bekken en bekkenfysiotherapie bij de man. Bekkenfysiotherapeutische expertise is nodig bij aanvullende diagnostiek en bij de behandeling van de hypertone bekkenbodem, chronische bekkenpijn, chronische prostatitis, prostaatkanker, benigne prostaathyperplasie (BPH), transurethrale resectie van de prostaat (TURP), lower urinary tract symptoms (LUTS) en seksuele disfuncties, en daarnaast bij colorectale en anale kanker. Een nieuwe uitdaging is de bekkenfysiotherapie als onderdeel van de prevalidatie bij radicale prostatectomie en TURP. Het artikel sluit af met aanbevelingen om mannelijke fysiotherapeuten naar deze specialisatie toe te motiveren.
Analysis of the energy-capturing characteristics of floats for point absorption wave energy generators
Authors: Li Yongguo , Qin Can , Du Jie , Zheng Dingjian , Zhu Qiuying 
Published: September 2022

AbstractIn this study, based on four common float shapes, the factors affecting the energy-capturing characteristics of floats are determined using mathematical models of floats moving in waves. By using the orthogonal experimental method and AQWA hydrodynamics simulations, the influence degrees of different factors on the float capture width ratio were determined through the range analysis. Based on the frequency-domain conditions, the variation trends in the float energy-capturing characteristics are summarized, and the relationships between the float energy-capturing characteristics and the resonance frequency and wave force are discussed. It was concluded that the energy-capturing characteristics of slender cylindrical floats were better at the resonance frequency, and the wave force acting on the float is not the most powerful basis to judge the energy-capturing characteristics of the float. This study’s conclusions provide some reference for the design and optimization of floats.
Graphical abstract
In this study, the energy-capturing characteristics of floats in a point absorption wave energy generator under the action of multiple factors are studied. At a higher draft depth, a “slender” float shape had a larger capture width ratio. The wave force received by the float could not be the basis for determining the float energy-capturing characteristics.
Rosa davurica inhibits skin photoaging via regulating MAPK/AP-1, NF-κB, and Nrf2/HO-1 signaling in UVB-irradiated HaCaTs
Authors: Fang Minzhe , Lee Hyun-Myung , Oh Sarang , Zheng Shengdao , Bellere A. D. , Kim Minseon , Choi Junhui , Kim Myeongju , Yu Duna , Yi Tae-Hoo 
Published: September 2022

AbstractRosa davurica is widely used to treat various kinds of diseases because of its high antioxidant, antiviral and anti-inflammatory activities. This use of plant-based materials as medicine is called phytomedicine and has been widely practiced since time immemorial. However, the pharmacological mechanism of R. davurica in skin photoaging is not yet fully understood. Therefore, this study was carried out to evaluate the recovery effects of R. davurica leaf extracts (RDE) in UVB-irradiated human skin keratinocytes (HaCaTs) and investigate whether RDE is a potential therapeutic agent against skin photoaging. The expression of aging-related markers including mitogen-activated protein kinases/activator protein 1 (MAPK/AP-1), nuclear factor-κB (NF-κB), and nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) was evaluated using Western blot analysis. The reactive oxygen species (ROS) was also used by FACS in HaCaTs. Findings indicated that RDE is efficient in scavenging free radicals and dose-dependently reducing ROS generation. Furthermore, RDE notably decreased UVB-induced matrix metalloproteinase-1 (MMP-1) expression through inhibition of MAPK/AP-1 and NF-κB signaling pathways as well as induced blocking of extracellular matrix (ECM) degradation in UVB-irradiated HaCaTs. In addition, RDE improved Nrf2/HO-1 signaling that increases oxidative defense capacity and enhances transforming growth factor-beta (TGF-β) signaling activation to promote procollagen type I synthesis, relieving UVB-induced skin cell damage. In conclusion, the protective effects of RDE on skin cellular components suggest that it has a high biological potential for skin protection from UVB-induced skin photoaging and is a good candidate for drug and cosmetic application.
Graphical abstract
A survey study on knowledge and attitude towards pain management and associated factors among emergency Nurses,2021. Multi-center cross-sectional study
Authors: Admassie Belete Muluadam , Ferede Yonas Admasu , Lema Girmay Fitiwi , Ayen Biresaw 
Published: September 2022

Abstract

Background
Poor knowledge and attitude of nurses regarding pain may contribute to inadequate pain management. Nurses, as the primary caregivers in the emergency department, should have adequate knowledge and a good attitude towards pain management. The aim of this study was to determine the level of knowledge and attitude towards pain management and other factors among emergency nurses.

Methods
A multi-center, institutional based, cross-sectional study was conducted on 153 nurses from May 01 to May 30, Ethiopia, 2021. Self–completed survey questionnaires were distributed using a modified and validated ‘Knowledge and Attitudes Survey Regarding Pain (KASRP)’ tool and analyses were performed using SPSS version 20. Descriptive statistics were used to summarize the characteristics of the participants, and the results were prepared using narrations, percentages, and tables. To demonstrate the strength of the association, the crude odds ratio and adjusted odds ratio with the corresponding 95% CI were calculated. Variables with a p-value of <0.05 were considered statistically significant after multivariate analysis.

Result
The mean percentage score of knowledge and attitude towards pain management was 52.8% (SD = 13). Prior pain management, training, and years of work experience as an emergency nurse were associated with good pain management knowledge and attitude.

Conclusion and recommendations
The level of knowledge and attitude of emergency nurses toward pain management were poor. So, we suggest all stakeholders who participate in nursing education work together to educate nurses to a higher level of education and deliver pain management training to enhance their knowledge and attitude towards pain management.

Highlights