bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key factors in the internationalization process of born global Romanian software companies: an exploratory study
Authors: Butnariu Anca , Filipeanu Dumitru , Luca Florin Alexandru 
Published: July 2022

Abstract
The general objective of this study is to bring several insights into the enablers of the internationalization process of Romanian software technology companies, in the framework of recent research that challenged the traditional theories on internationalization. Due to Romanian software companies’ increasing levels of international direct investments and the strategic importance of this sector, our aim was to uncover the most relevant features that several born global firms in this industry possess. More explicitely, our goal is to elucidate the factors and distinctive conditions that trigger the occurrence and further development of Born Globals, in comparison with the companies that do not show the fast internationalization tendency from their inception or soon after. Our qualitative empirical research, based on four case studies, argues that strategic flexibility, innovation capability and entrepreneurial ability allowed sees in IT Romanian industry to rapidly internationalise in unknown markets and become international successful players. This confirms existing theoretical frameworks that recognised knowledge-intensity, capacity of networking and client orientation as important internationalization explaining mechanisms. Drawing on theories of internationalization as RBV, KBV, DCV, international entrepreneurship, we argue that SMEs in IT industry are characterized by a mix of the features mentioned by these frameworks. Our results determine that BGs are more entrepreneurial, have more innovation capabilities, learning capability, are more customer-oriented and are part of collaborative networks, have flexible strategies than other companies. The prior international experience or market knowledge of the founders was not found to be one of the triggers that led to the rapid international success of romnaina IT companies.
Prevalence and Factors Associated with Suicidal Ideation and Attempts Among Mentally Ill Patients in Psychiatry OPD at St. Paulo’s Hospital Millennium Medical College, in Addis Ababa, Ethiopia
Authors: Dawud Awol , Menna Takele , Teshome Tesfalem , Alayu Mikiyas , Ayalew Mohammed 
Published: July 2022

Abstract
Background: Every year, more than 800,000 people die due to suicide (one person every 40 s), ranking as the second leading cause of death next to traffic accidents between 15–29 years of age. The objective of this study was to assess the prevalence and factors associated with suicidal ideation and attempts among mentally ill patients. Method: Institutional based cross-sectional study was conducted from December/2019 to January/2020. Data was collected by using a convenient sampling technique until the required sample size was achieved. The total sample size was 385. Suicidal Behavavior Quistionnare Revised (SBQ-R), Oslo scale and self-prepared to assess suicide.Data collection was by psychiatry professionals through face-to face interview. Data was analyzed, bivariate and multivariable logistic regression were conducted by using SPSS version 23. Result: A total of 385 patients were participated in the study. Of these, 216 (56%) were males. The prevalence of suicide ideation was 255 (66.2%). The odds of suicidal ideation and attempt was almost three times higher [AOR=2.79, 95% CI (1.11, 6.98)] among patients who felt hopeless, OR was around two times higher [AOR= 2.44, 95% CI (1.17, 5.08) among patients who had family history of suicide, the OR is almost three times higher [AOR= 2.56, 95% CI (1.00, 6.53)] among patients who stopped their medication, the OR is around two times higher [AOR= 2.25, 95% CI (1.14, 4.46)], the OR of suicidal ideation and attempts was almost six and four times higher [ AOR= 5.86, 95% CI (1.30, 26.41) and AOR= 3.61, 95% CI (1.01, 12.88)] among patients who educate primary and secondary level education respectively. Conclusion: In this study, which was performed in Ethiopia, suicidal ideation and attempt common problems among males than females. And the prevalence of suicide ideation and attempts were showing a significant public health issue among hospital attending and chronic mentally ill patients’ adolescents that requires a great emphasis. And we recommend that suicide prevention needs to involve non-governmental and non-profit organizations, universities, and civil society at different levels.
Qualitative Content Analysis of The New York Times Coronavirus (2019-n-COV) Articles with Natural Language Processing (NLP) and Leximancer
Authors: Tunca Sezai , Sezen Bulent 
Published: July 2022

Abstract
This study aimed to analyze coronavirus (2019-nCOV) discourse related articles published on NyTimes.com with NLP methods and Leximancer. The textual data of the research were collected with the Orange3 software text mining tool via the NyTimes.com API, and qualitative content analysis was carried out with Leximancer and NLP methods. The research data were selected as three terms (first-mid-last) depending on the determined date ranges during pandemic. The textual data set was analyzed with Leximancer using the qualitative content analysis method and conducted sentiment measurements of the published articles. Then, using Leximancer concept maps, explained concepts and their relationships by visualizing them to identify pandemic discourse. Leximancer results, the distance and proximity positions of some themes related to NyTimes.com pandemic discourse were revealed according to their conceptual definitions. In context of findings can be concluded that NyTimes.com coronavirus (2019-nCOV) discourse some of their concepts have changed periodically, and some concepts remain the same. NyTimes.com's pandemic discourse consisted of a certain part of the concepts that guide human behavior and content that may cause anxiety. Sentiment analysis results were supported these findings Another result was that the findings showed us that the contents of the coronavirus articles were support official policies.
An Update on Promising Agents against COVID-19: Secondary Metabolites and
Mechanistic Aspects
Authors: Jamshidnia Maryam , Sewell Robert D.E. , Rafieian-Kopaei Mahmoud 
Published: July 2022

Background:
Coronavirus disease 2019 (COVID‑19) is caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) and is associated with a high level of mortality.

Objective:
This updated review aims to present the most important traditional medicinal plants and some of
their secondary metabolites that have previously and more recently been shown to affect viruses and may represent
a beneficial contributory step against SARS-CoV-2 as the cause of COVID-19. Moreover, the mechanism
aspects of these secondary metabolites were discussed, which may help find more reliable drugs against SARSCoV-
2.

Methods:
Articles were searched on scientific websites including Google Scholar, Scopus, Web of Science,
PubMed, and IranMedex using the search terms herbal medicine and traditional medicine with coronavirus,
SARS-CoV-2, or COVID-19. Human, animal, and in vitro studies were identified in the search.

Results:
Medicinal plants and their secondary metabolites may possess a potential role in combating this disease,
and researchers suggest that some of these plants and their constituent compounds have inhibitory activity
on coronaviruses. Numerous medicinal plants, their extracts, and secondary metabolites have been investigated
over a period of time for antiviral activity. Among them, kaempferol, silybin, myricitrin, licoleafol, and curcumin
are promising agents with potential activity against SARS-CoV-2. Natural compounds can form strong
bonds with the active sites of SARS-CoV-2 protease. Structural and non-structural SARS-CoV-2 proteins such
as Spike protein, PLpro, and 3CLpro are inhibited by these phytochemicals.

Conclusion:
Prospective treatments targeted at the life cycle stages of the virus may eventuate from research
endeavors, and it must not be discounted that therapy originally derived from plant secondary metabolite
sources may potentially have a part to play.
Outcomes of a Newly Established Electromagnetic Navigation Bronchoscopy Service in the Middle East
Authors: Uzbeck Mateen , Zoumot Zaid , Shafiq Irfan , El-Kaissi Mahmoud , Souilamas Redha , Wahla Ali Saeed 
Published: July 2022

Aims:
Electromagnetic Navigation Bronchoscopy (EMNB) is a useful tool for the bronchoscopist to target peripheral pulmonary lesions. It has a well-established efficacy and safety profile; however, there are no studies describing its utility in a Middle Eastern population. In this paper, we describe the efficacy and safety outcomes of a newly established EMNB service.

Background:
The diagnosis of peripheral pulmonary lesions presents a significant challenge to the bronchoscopist, especially in the era of increased thoracic imaging with computerized tomography (CT) scans. EMNB is a relatively novel technique that utilizes an image-guided localization system akin to Global Positioning Satellite (GPS) technology, offering the bronchoscopist an accurate navigational pathway to sample peripheral pulmonary targets.

Objective:
We present our initial experience of performing EMNB and report our diagnostic and safety outcomes with EMN bronchoscopy.

Methods:
We conducted a retrospective review of the medical notes of all patients booked for EMNB from May 2015 to December 2019 at our tertiary care center using the electronic medical record system.

Results and Discussion:
Fifty-five patients were scheduled for EMNB, and 47 patients (24 males, 23 females) had EMNB-guided sampling between May 2015 and December 2019. The median age of the patients was 61 years (IQR 49.5-74.3). A bronchus sign was present on the CT chest in 29 (61.7%) cases. Thirty-one (66%) patients had positive EMNB guided samples. There was a weak correlation between the lesion size and the positive EMNB guided sampling (r: 0.34). Twenty-one of 29 (72%) patients with positive bronchus signs had positive EMNB guided samples, compared to 10/18 (56%) patients without bronchus signs; however, the difference was not statistically significant (p-value 0.335). When the presence or absence of rapid onsite examination of cytopathological specimens (ROSE) was compared during the procedure, a trend favoring the presence of ROSE could be seen, but this was statistically non-significant (p-value 0.078). In this series, one patient with pre-existing triple vessel coronary artery disease developed an inferior wall ST-segment elevation myocardial infarction (STEMI), likely secondary to spasm. This patient recovered completely and was discharged from the hospital.

Conclusion:
This study demonstrates that EMNB can be safely performed in a Middle Eastern population with results similar to those reported in major international studies. The highest diagnostic yield was in patients with a bronchus sign on a CT scan, and combining EMNB with ROSE can increase the chances of having a positive diagnostic bronchoscopy. However, patients and physicians need to be aware of the need to follow up with the patients with negative biopsies to ensure that false negatives are not missed.
The Impact of Complex Intervention on the Dynamics of Children’s Development with ASD
Authors: Mambetalina Alija Saktaganovna , Borankulovna Opabekova Aislu , Kanatovna Mukatayeva Saniya , Ukatayevna Utemissova Gulmira , Pamazanovna Mandykayeva Almagul , Tlegenovna Utaliyeva Zhanna 
Published: July 2022

Background:The study of the complex development of a child with ASD is an important and relevant topic for discussion at the present moment. Complex intervention involves the interaction of specialists such as psychologists, speech therapists, speech pathologists, sensory integration and adaptive physical culture (APC) specialists for the rapid dynamics of children with ASD. To track the development of children, we used a comprehensive assessment of the child’s current skills – VB-MAPP.Objective:The objective of this study is to show the effectiveness of complex intervention in the correction of children with ASD.Methods:To track the development of children, we used a comprehensive assessment of the child's current skills – VB-MAPP. This test is the most widely used tool among behavioral analysts.Results:After processing the data, it becomes clear that the first group, which received classes from one specialist for 1 academic hour three times a week, has relatively low indicators of skill development compared to the second group. Children from the second group who received complex intervention from several specialists every day for 4 hours a day demonstrated positive dynamics in all areas of development.Conclusion:The results of the study confirm that the main condition ensuring the positive dynamics of the development of a child with ASD is the comprehensive intervention of specialists specializing in correctional work.
Recent Trends of Therapeutic Strategies against COVID-19
Authors: Zhang Hai-Long , Ge Liya , Li Yong-Xia , Zhou Ai-Feng 
Published: July 2022

Background:
The coronavirus disease 2019 (COVID-19), caused by a virus named SARS-CoV-2, has spread rapidly around the world.

Objective:
To better understand the recent development of therapeutic strategies against COVID-19 and the patent landscape, we analyze patent documents surrounding COVID-19.

Methods:
The patent documents surrounding COVID-19 from 6 major countries, including China, the US, Russia, Korea, India, and Singapore, were analyzed by a comprehensive analysis. The patent documents surrounding COVID-19 were published from November 2019 to April 2021.

Results:
The analysis showed that China was the most prolific country in patents surrounding COVID-19, with over 300 published patent documents. A significant feature of therapeutic strategies against COVID-19 was the contribution of traditional Chinese medicines in China. Our study showed the number of patents in the therapeutic area was about half in all patent applications, which indicated that therapeutic approaches, detecting, and protecting approaches were the same in importance against COVID-19.

Conclusion:
The main therapeutic strategies against COVID-19 include traditional Chinese medicines, chemical drugs, and vaccines. An effective and fast approach against COVID-19 is to use vaccines or traditional Chinese Medicines. The present study showed the development of a therapeutic strategy surrounding COVID-19 based on patent insight for the first time and provided new insight into therapeutic strategy against COVID-19.
Physicochemical Properties, Antioxidant and Antimicrobial Activities
of Ethiopian Sweet Basil (Ocimum basilicum L.) Leaf and
Flower Oil Extracts
Authors: Yibeltal Getachew , Yusuf Zekeria , Desta Mulugeta 
Published: July 2022

Background:
The occurrence of multidrug resistant pathogenic microbes has initiated
the development of natural antimicrobial agents from plants. Oils from herbal sources have drawn
scientific interest due to their potential source of bioactive compounds.

Objective:
This study was aimed to examine the physicochemical and biological activities including
antioxidant and antimicrobial potential of the oil extracted from basil leaves and flowers.

Methods:
The physicochemical properties of the oil extracts were measured based on oil yield,
specific gravity, acid value, free fatty acids and peroxide values whilst the antioxidant activities
were assessed by ascorbic acid, DPPH (2, 2- diphenyl-1-picrylhydrazyl), and hydrogen peroxide
free radical scavenging activities. The antimicrobial experiment was conducted based on disc diffusion
and broth dilution methods.

Results:
The result of antioxidant activity of Ocimum basilicum indicated significantly higher
DPPH (86.45%) for leaf oil extract. The strongest antibacterial activity with maximum zone of inhibition
(15.47 mm), minimum inhibitory concentration MIC (0.09 μg/ml), and corresponding
minimum bactericidal concentration MBC (0.19 μg/ml) was exhibited by the flower oil extract
against Staphylococcus aureus ATCC-25923. The strongest antifungal activity with maximum
zone of inhibition (15.90 mm), MIC (0.125 μg/ml, the least value), and minimum fungicidal concentration
MFC (0.09 μg/ml) were recorded for leaf oil against Candida albicans.

Conclusion:
It can be concluded from the present study that the sweet basil flower and leaf oil extracts
can be potential antioxidant, antibacterial, and antifungal agents.
Web-Based Alcohol and Sexual Assault Prevention Program With Tailored Content Based on Gender and Sexual Orientation: Preliminary Outcomes and Usability Study of Positive Change (+Change)
Authors: Gilmore Amanda K , Leone Ruschelle M , Oesterle Daniel W , Davis Kelly Cue , Orchowski Lindsay M , Ramakrishnan Viswanathan , Kaysen Debra 
Published: July 2022

Background
Alcohol use and sexual assault are common on college campuses in the United States, and the rates of occurrence differ based on gender identity and sexual orientation.

Objective
We aimed to provide an assessment of the usability and preliminary outcomes of Positive Change (+Change), a program that provides integrated personalized feedback to target alcohol use, sexual assault victimization, sexual assault perpetration, and bystander intervention among cisgender heterosexual men, cisgender heterosexual women, and sexual minority men and women.

Methods
Participants included 24 undergraduate students from a large university in the Southwestern United States aged between 18 and 25 years who engaged in heavy episodic drinking in the past month. All procedures were conducted on the web, and participants completed a baseline survey, +Change, and a follow-up survey immediately after completing +Change.

Results
Our findings indicated that +Change was acceptable and usable among all participants, despite gender identity or sexual orientation. Furthermore, there were preliminary outcomes indicating the benefit for efficacy testing of +Change.

Conclusions
Importantly, +Change is the first program to target alcohol use, sexual assault victimization, sexual assault perpetration, and bystander intervention within the same program and to provide personalized content based on gender identity and sexual orientation.

Trial Registration
ClinicalTrials.gov NCT04089137; https://clinicaltrials.gov/ct2/show/NCT04089137
Fairness and Luck: Contract Away or Come What May?
Authors: Asay H. Scott , Garrett Jace B. , Tayler William B. 
Published: July 2022

ABSTRACT
Prior research shows that managers use discretion to reduce the effect of “bad luck” on employees’ performance-based compensation, but not to reduce the effect of “good luck,” due to fairness concerns. In a setting without manager discretion, we investigate whether objective compensation plans that account for luck can be used to reduce fairness concerns. We show that although such compensation plans are perceived as fairer ex ante, they do not produce uniformly higher perceived fairness ex post. Individuals who experience bad luck believe their compensation is fairer if the compensation plan limits the effect of luck on their compensation than if the compensation plan allows luck to influence their compensation. In contrast, individuals who experience good luck believe their compensation is less fair if the compensation plan limits the effect of luck on their compensation. These findings highlight the complex relationship among incentives, employee selection, retention, satisfaction, and motivation.
JEL Classifications: D8; J3; M52.
Incretin-Based Drugs and the Risk of Acute Liver Injury Among Patients With Type 2 Diabetes
Authors: Pradhan Richeek , Yin Hui , Yu Oriana H.Y. , Azoulay Laurent 
Published: July 2022

OBJECTIVE
To determine whether the use of dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1 RAs), separately, is associated with an increased risk of acute liver injury compared with the use of sodium–glucose cotransporter 2 (SGLT-2) inhibitors.

RESEARCH DESIGN AND METHODS
We used the U.K. Clinical Practice Research Datalink linked with the Hospital Episode Statistics Admitted Patient Care and the Office for National Statistics databases to assemble two new-user, active-comparator cohorts. The first included 106,310 initiators of DPP-4 inhibitors and 27,277 initiators of SGLT-2 inhibitors, while the second included 9,470 initiators of GLP-1 RAs and 26,936 initiators of SGLT-2 inhibitors. Cox proportional hazards models with propensity score fine stratification weighting were used to estimate hazard ratios (HRs) and 95% CIs of acute liver injury.

RESULTS
Compared with SGLT-2 inhibitors, DPP-4 inhibitors were associated with a 53% increased risk of acute liver injury (HR 1.53, 95% CI 1.02–2.30). In contrast, GLP-1 RAs were not associated with an overall increased risk of acute liver injury (HR 1.11, 95% CI 0.57–2.16). However, an increased risk was observed among female users of both DPP-4 inhibitors (HR 3.22, 95% CI 1.67–6.21) and GLP-1 RAs (HR 3.23, 95% CI 1.44–7.25).

CONCLUSIONS
In this population-based study, DPP-4 inhibitors were associated with an increased risk of acute liver injury compared with SGLT-2 inhibitors in patients with type 2 diabetes. In contrast, an increased risk of acute liver injury was observed only among female GLP-1 RA users.
Application of Reward and Punishment to Develop Disciplinary Behavior of Early Childhood
Authors: Saputri Aulia Indah , Widyasari Choiriyah 
Published: July 2022

Reward includes the process carried out by giving reinforcement (reinforcement) in the form of rewards, so that with the award it is expected that it will naturally arise positive behavior and continue to do it better in the future. So that with the award of children will be considered to play a role or useful and feel valued for their efforts that can raise their status. In other words, reward can be said as one of the steps taken by children to give an award to children who have done their job properly. By giving rewards children are expected to maintain and even improve the quality of their achievement in the future. Punishment also has an equally important role in shaping or improving children's attitudes. Punishment is performed by children to provide improvements to unsatisfactory behavior or achievement. With the punishment it is expected that the child is aware of the mistakes he made so that he can consider something that will be done next. Punishment is done to avoid unpleasant conditions by correcting or minimizing unfavorable behavior. Therefore, with the behavior accompanied by punishment, the behavior (negative) will be reduced and will not even repeat. Punishment is done to avoid unpleasant conditions by correcting or minimizing unfavorable behavior. Therefore, with the behavior accompanied by punishment, the behavior (negative) will be reduced and will not even repeat. Punishment is done to avoid unpleasant conditions by correcting or minimizing unfavorable behavior. Therefore, with the behavior accompanied by punishment, the behavior (negative) will be reduced and will not even repeat. In overcoming this discipline required the existence of school rules, consistency and implementing school discipline and partnerships with parents. Sanctions must not be given emotionally and according to taste, but must refer to existing standards and rules and aim at educating. With these things discipline in the school can be upheld and restored. Children who have problems with bad behavior can be helped and restored. It is hoped that such steps and attitudes will have a major impact on conducive conditions so as to create good learning outcomes and more positive changes in children's behavior.