bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrast-enhanced mammography-guided biopsy: technical feasibility and first outcomes
Authors: Alcantara R. , Posso M. , Pitarch M. , Arenas N. , Ejarque B. , Iotti V. , Besutti G. 
Published: July 2022

Abstract
Objectives
To evaluate the feasibility of contrast-enhanced mammography (CEM)-guided biopsy at Hospital del Mar, a Spanish university hospital.

Methods
We retrospectively reviewed all consecutive women with a suspicious enhancing finding eligible for CEM-guided biopsy, who were prospectively enrolled in a pre-marketing clinical validation and feasibility study (October 2019 to September 2021). CEM-guided biopsy is a stereotactic-based procedure that, by using intravenous iodinated contrast media administration and dual-energy acquisition, provides localisation of enhancing lesions. All the biopsies were performed using a vacuum-assisted device. We collected procedural characteristics (patient position and type of approach), and histopathological results. Feasibility endpoints included success (visualisation of the enhancing lesion, post-procedural biopsy changes and clip placement), procedural time, number of scout acquisitions and complications.

Results
A total of 66 suspicious enhancing lesions (18.0% foci, 44.0% mass, 38.0% non-mass enhancement; median size 8.5 mm) in 64 patients (median age 59 years, mostly minimal [48.4%] or mild [32.8%] background parenchymal enhancement) were referred for CEM-guided biopsy in the study period. The success rate was 63/66 (95.4%). Amongst successful procedures, patients were most frequently seated (52/63, 82.5%) and the preferred approach was horizontal (48/63, 76.2%). Median total time per procedure was 15 min. Median number of acquisitions needed before targeting was 2 (range 1–4). Complications consisted of hematoma (17/63, 27%) and vasovagal reaction (2/63, 3.2%). At histology, the malignancy rate was 25/63 (39.7%).

Conclusion
In this first patient series, CEM-guided breast biopsy was feasible, with success and complication rates similar to those previously reported for magnetic resonance guidance.

Key points
• CEM may be used to guide biopsy of enhancing lesions through a stereotactic-based procedure combined with intravenous iodinated contrast media administration and dual-energy acquisition.
• In this first patient series (n = 64), the success rate of CEM-guided biopsy was above 95%, the only complications were hematoma (22.2%) and vasovagal reaction (3.2%), and median total time per procedure was 15 min.
• CEM-guided biopsy is feasible and could potentially be a widely available biopsy technique for enhancing-only lesions.
New Results on Independent Sets in Extensions of $$2K_2$$-free Graphs
Authors: Mosca Raffaele 
Published: July 2022

AbstractThe Maximum Weight Independent Set Problem (WIS) is a well-known NP-hard problem. A popular way to study WIS is to detect graph classes for which WIS is solvable in polynomial time, with particular reference to hereditary graph classes, i.e., defined by a hereditary graph property or equivalently by forbidding one or more induced subgraphs. For any two graphs G and H, $$G+H$$

G
+
H

denotes the disjoint union of G and H. A $$lK_2$$

l

K
2

is the disjoint union of l edges. A $$Y_{m,m}$$

Y

m
,
m

is the disjoint union of two stars of $$m+1$$

m
+
1

vertices plus one vertex that is adjacent only to the centers of such stars. For any graph family $${{{\mathcal {Y}}}}$$
Y
, the class of $${\mathcal Y}$$
Y
-free graphs is formed by graphs which are Y-free for every $$Y \in {{{\mathcal {Y}}}}$$

Y
∈
Y

, and the class of $$lK_2+{{{\mathcal {Y}}}}$$

l

K
2

+
Y

-free graphs is formed by graph which are $$lK_2+Y$$

l

K
2

+
Y

-free for every $$Y \in {\mathcal Y}$$

Y
∈
Y

. The main result of this manuscript is the following: For any constant m and for any graph family $${{{\mathcal {Y}}}}$$
Y
which contains an induced subgraph of $$Y_{m,m}$$

Y

m
,
m

, if WIS is solvable in polynomial time for $${{{\mathcal {Y}}}}$$
Y
-free graphs, then WIS is solvable in polynomial time for $$lK_2+{{{\mathcal {Y}}}}$$

l

K
2

+
Y

-free graphs for any constant l. That extends some known polynomial results, namely, when $${{{\mathcal {Y}}}} = \{Y\}$$

Y
=
{
Y
}

and Y is a fork or is a $$P_5$$

P
5

. The proof of the main result is based on Farber’s approach to prove that every $$2K_2$$

2

K
2

-free graph has $$O(n^2)$$

O
(

n
2

)

maximal independent sets (Farber in Discrete Math 73:249–260, 1989), which directly leads to a polynomial time algorithm to solve WIS for $$2K_2$$

2

K
2

-free graphs through a dynamic programming approach, and on some extensions of Farber’s approach.
Consumption of young child formulae in the Netherlands
Authors: de Jong Marjolein H. , Nawijn Eline L. , Verkaik-Kloosterman Janneke 
Published: July 2022

Abstract
Purpose
Adequate micronutrient intakes are essential for young children. Special young child formulae (YCF) intended for children from 1 year old are available in the Dutch market. Since YCF are enriched with many micronutrients, it has the potential to have a beneficial effect on young children, or might pose a risk on excessive micronutrient intakes. The current study investigated the characteristics of YCF users, and the effect of YCF use on micronutrient intakes.

Methods
Data from the Dutch National Food Consumption Survey (2012–2016; n = 440 children aged 1–2 year old) and the Dutch Food Composition Database (NEVO version 2016) were used to assess micronutrient intakes. Habitual intakes of users and non-users of YCF were calculated using Statistical Program to Assess Dietary Exposure (SPADE) and compared.

Results
In the Netherlands, YCF was consumed by 21% of the 1–2-year-olds. YCF contributed mostly to total vitamin D intake (76%) and between 0 and 50% for other micronutrients. Higher vitamin A, B1, C, D, E, total folate, iron and zinc intakes were observed among users, and higher potassium and phosphorus intakes were found among non-users. Risk of inadequate intake was low among both users and non-users for most nutrients, and the only elevated risk of excessive intake found was for zinc among YCF users.

Conclusion
YCF increased micronutrient intake, however, for most of the micronutrients there is already a low risk of inadequate intake. YCF increased the risk of excessive zinc intake. It is important that the addition of micronutrients to YCF is regulated, to prevent excessive intake.
HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS
Authors: Braems Elke , Bercier Valérie , Van Schoor Evelien , Heeren Kara , Beckers Jimmy , Fumagalli Laura , Dedeene Lieselot , Moisse Matthieu , Geudens Ilse , Hersmus Nicole , Mehta Arpan R. , Selvaraj Bhuvaneish T. , Chandran Siddharthan , Ho Ritchie , Thal Dietmar R. , Van Damme Philip , Swinnen Bart , Van Den Bosch Ludo 
Published: July 2022

AbstractA ‘GGGGCC’ repeat expansion in the first intron of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The exact mechanism resulting in these neurodegenerative diseases remains elusive, but C9 repeat RNA toxicity has been implicated as a gain-of-function mechanism. Our aim was to use a zebrafish model for C9orf72 RNA toxicity to identify modifiers of the ALS-linked phenotype. We discovered that the RNA-binding protein heterogeneous nuclear ribonucleoprotein K (HNRNPK) reverses the toxicity of both sense and antisense repeat RNA, which is dependent on its subcellular localization and RNA recognition, and not on C9orf72 repeat RNA binding. We observed HNRNPK cytoplasmic mislocalization in C9orf72 ALS patient fibroblasts, induced pluripotent stem cell (iPSC)-derived motor neurons and post-mortem motor cortex and spinal cord, in line with a disrupted HNRNPK function in C9orf72 ALS. In C9orf72 ALS/FTD patient tissue, we discovered an increased nuclear translocation, but reduced expression of ribonucleotide reductase regulatory subunit M2 (RRM2), a downstream target of HNRNPK involved in the DNA damage response. Last but not least, we showed that increasing the expression of HNRNPK or RRM2 was sufficient to mitigate DNA damage in our C9orf72 RNA toxicity zebrafish model. Overall, our study strengthens the relevance of RNA toxicity as a pathogenic mechanism in C9orf72 ALS and demonstrates its link with an aberrant DNA damage response, opening novel therapeutic avenues for C9orf72 ALS/FTD.
Use of a microsurgical vascular clip system for temporary bilateral occlusion of the four main uterine vessels for laparoscopic enucleation of very large intramural uterine fibroids
Authors: Younes Shadi , Radosa Marc , Schneider Achim , Radosa Julia , Eichenwald Alexey , Weisgerber Christiane , Aktas Bahriye 
Published: July 2022

Abstract
Objectives
The goal of this study was to examine the safety, feasibility, and effectiveness of the use of a microsurgical temporary vascular clip system to facilitate the laparoscopic enucleation of very large intramural uterine fibroids.

Methods
In this retrospective study, the surgical outcomes of 26 patients who underwent laparoscopic myomectomy with temporary uterine vessel clipping for very large (the largest measured diameter ≥ 9 cm) symptomatic intramural uterine fibroids in two tertiary referral hospitals between September 2017 and March 2020 were examined. Titan-made vascular clips (YASARGIL® Aneurysm Clip System) were used to temporarily occlude the bilateral uterine arteries and utero-ovarian vessels. Main outcomes included operating time, blood loss, number of leiomyomas and weight, conversion rate, intra- and postoperative complication rates, and length of hospital stay.

Results
Twenty six patients were included. Dominant intramural uterine fibroid diameters were 9–22 cm. The general characteristics of the patients were similar. The mean surgery duration and intraoperative blood loss were 175.3 ± 32.7 (range 120–250) min and 241.1 ± 103 (range 100–450) ml, respectively. The median postoperative drop in hemoglobin was 0.89 ± 0.75 g/dL. No patient required blood transfusion. No procedure was converted to laparotomy. No major intra- or postoperative complication occurred.

Conclusions
Laparoscopic myomectomy for very large intramural uterine fibroids can be performed safely and effectively, with less intraoperative blood loss, using vascular clips for temporary clamping of the bilateral uterine vessels.
Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups
Authors: Smith Jaclyn A. , Birring Surinder S. , Dicpinigaitis Peter V. , McGarvey Lorcan P. , Morice Alyn H. , Pavord Ian D. , Satia Imran , Green Stuart , Iskold Beata , La Rosa Carmen , Li Qing , Martin Nguyen Allison , Schelfhout Jonathan , Muccino David 
Published: July 2022

AbstractIntroductionIn phase 3 trials (COUGH-1/COUGH-2), gefapixant 45 mg twice daily significantly reduced 24-h cough frequency vs placebo in refractory or unexplained chronic cough (RCC or UCC).MethodsHere, the efficacy of gefapixant 45 mg vs placebo was evaluated across COUGH-1/COUGH-2 in predefined subgroups based on sex, region, age, cough duration, cough severity, cough frequency, and diagnosis (RCC, UCC). Awake cough frequency reductions at Week 12 and LCQ response rates (i.e., ≥ 1.3-point improvement) at Week 24 were assessed.ResultsAmong 1360 participants analyzed, gefapixant 45 mg resulted in consistent awake cough frequency reductions overall and across predefined subgroups at Week 12. Gefapixant also resulted in improved LCQ scores across subgroups at Week 24; ≥ 70% of participants in each subgroup treated with gefapixant 45 mg had an LCQ response.ConclusionThese data suggest gefapixant 45 mg provides consistent objective and subjective efficacy across subgroups of individuals with RCC or UCC.
Volcanic electrification: recent advances and future perspectives
Authors: Cimarelli Corrado , Behnke Sonja , Genareau Kimberly , Harper Joshua Méndez , Van Eaton Alexa R. 
Published: July 2022

Abstract
The electrification of volcanic plumes has been described intermittently since at least the time of Pliny the Younger and the 79 AD eruption of Vesuvius. Although sometimes disregarded in the past as secondary effects, recent work suggests that the electrical properties of volcanic plumes reveal intrinsic and otherwise inaccessible parameters of explosive eruptions. An increasing number of volcanic lightning studies across the last decade have shown that electrification is ubiquitous in volcanic plumes. Technological advances in engineering and numerical modelling, paired with close observation of recent eruptions and dedicated laboratory studies (shock-tube and current impulse experiments), show that charge generation and electrical activity are related to the physical, chemical, and dynamic processes underpinning the eruption itself. Refining our understanding of volcanic plume electrification will continue advancing the fundamental understanding of eruptive processes to improve volcano monitoring. Realizing this goal, however, requires an interdisciplinary approach at the intersection of volcanology, atmospheric science, atmospheric electricity, and engineering. Our paper summarizes the rapid and steady progress achieved in recent volcanic lightning research and provides a vision for future developments in this growing field.
Glycol bearing perylene monoimide based non-fullerene acceptors with increased dielectric permittivity
Authors: Fürk Peter , Hofinger Jakob , Reinfelds Matiss , Rath Thomas , Amenitsch Heinz , Scharber Markus Clark , Trimmel Gregor 
Published: July 2022

AbstractPerylene monoimide based electron acceptors have great properties for use in organic solar cells, like thermal stability, strong absorption, and simple synthesis. However, they typically exhibit low values for the dielectric permittivity. This hinders efficient exciton dissociation, limiting the achievable power conversion efficiencies. In this work, we present the synthesis and utilization of two new acceptor–donor-acceptor (A-D-A) molecules, comprising perylene monoimide as electron withdrawing A unit. Oligo ethylene glycol side chain modified carbazole (PMI-[C-OEG]) and fluorene (PMI-[F-OEG]) linkers were used as electron rich D units, respectively. The polar side chains are expected to increase the polarizability of the molecules and, thus, their permittivity according to the Clausius–Mossotti relationship. We found that the incorporation of glycol chains improved the dielectric properties of both materials in comparison to the reference compounds with alkyl chains. The permittivity increased by 18% from 3.17 to 3.75 for the carbazole-based non-fullerene acceptor PMI-[C-OEG] and by 12% from 3.10 to 3.47 for the fluorene-based acceptor PMI-[F-OEG]. The fabricated solar cells revealed power conversion efficiencies of 3.71 ± 0.20% (record 3.92%) with PMI-[C-OEG], and 1.21 ± 0.06% (record 1.51%) with PMI-[F-OEG].
Graphical abstract
Investigation of the esthetic perception of different canine parameters
Authors: Schwefer Niklas , Freitag-Wolf Sandra , Meyer Gunnar , Kern Matthias 
Published: July 2022

AbstractObjectivesThe aim of this study is to analyze the esthetic perception of selected canine features, namely crown length, shade, inclination, and angle of incisal edge tip.Materials and methodsThe anterior maxillary teeth of a Central European woman were photographed and digitally modified in order to investigate esthetic perceptions of the above four categories. Three groups of examiners with different levels of experience in the field of dentistry (laypersons/inexperienced dental students, advanced dental students, dentists) evaluated the photographs twice with the help of visual analogue scales.ResultsThe best-evaluated canines have approximately the same length as the central incisor, have the same shade as the other anterior teeth, are best embedded in a lighter overall tooth shade, are neutral to slightly palatal inclined, and have a right angled to rounded incisal edge (≥ 90°). The canines evaluated as least esthetic, however, are longer than the central incisors, darker, inclined labially, and have a tapered incisal edge. No significant differences could be found between the evaluations of the groups with regard to the four feature categories.ConclusionsLaypersons, advanced dental students, and dentists generally evaluate according to the same esthetic standards. Gender does not have a significant influence on evaluation. Clear definitions of esthetically favored shades, incisal edge shapes, inclination, and lengths of the canines can be given.Clinical relevanceSince the esthetics of the smile line play a critical role for patients, dentists, dental technicians, and their supplying industry, knowledge of the esthetically preferred morphology of canines is essential.Clinical significanceThe aim of this study is to give clear definitions of esthetically favored shades, incisal edge shapes, and lengths of the canines, as the esthetics of the smile line play a critical role for patients, dentists, dental technicians, and their supplying industry (e.g., denture tooth manufacturers). Precise knowledge of esthetic preferences is important in clinical practice for both dentists and dental technicians, for example, in order to adequately advise patients regarding esthetic corrections. Also, in the case of missing teeth, this knowledge is essential for optimal and satisfactory restorations. Thus, this study can contribute to the satisfaction of general practitioners and patients.
In Silico Meta-Analysis of Boundary Conditions for Experimental Tests on the Lumbar Spine
Authors: Borrelli Simone , Putame Giovanni , Pascoletti Giulia , Terzini Mara , Zanetti Elisabetta M. 
Published: July 2022

AbstractThe study of the spine range of motion under given external load has been the object of many studies in literature, finalised to a better understanding of the spine biomechanics, its physiology, eventual pathologic conditions and possible rehabilitation strategies. However, the huge amount of experimental work performed so far cannot be straightforwardly analysed due to significant differences among loading set-ups. This work performs a meta-analysis of various boundary conditions in literature, focusing on the flexion/extension behaviour of the lumbar spine. The comparison among range of motions is performed virtually through a validated multibody model. Results clearly illustrated the effect of various boundary conditions which can be met in literature, so justifying differences of biomechanical behaviours reported by authors implementing different set-up: for example, a higher value of the follower load can indeed result in a stiffer behaviour; the application of force producing spurious moments results in an apparently more deformable behaviour, however the respective effects change at various segments along the spine due to its natural curvature. These outcomes are reported not only in qualitative, but also in quantitative terms. The numerical approach here followed to perform the meta-analysis is original and it proved to be effective thanks to the bypass of the natural variability among specimens which might completely or partially hinder the effect of some boundary conditions. In addition, it can provide very complete information since the behaviour of each functional spinal unit can be recorded. On the whole, the work provided an extensive review of lumbar spine loading in flexion/extension.
What is in a Name: Defining Key Terms in Urban Air Mobility
Authors: Andritsos Konstantinos , Scott Benjamyn I. , Trimarchi Andrea 
Published: July 2022

Abstract

As the world’s population increases, new ways of improving transportation systems in, around and between urban areas are being suggested. Early discussions on this have been technology-focused, pointing at the use of Unmanned Aircraft Systems (UAS) for cargo delivery and electrical Vertical Take-Off and Landing (eVTOL) aircraft for passenger transportation. Recently, the term ‘Urban Air Mobility’ has become widely used to encompass these vehicles within a new mobility ecosystem. However, due to deficiencies in this term, other proposals – namely ‘Advanced Air Mobility’, ‘New Air Mobility and ‘Innovative Air Mobility’ – have emerged. The rise in different terms can lead to confusion as their scope is not always fully known or appreciated, and they are often used interchangeably. This paper, therefore, shifts focus from the recent debate about the definition of ‘UAS’ to the aforementioned ecosystem terms so to address and evaluate them as potentially different aspects of the same concept. An interpretive approach of the terms, an assessment of their major characteristics, as well as an analysis of their relationship with the aircraft types will take place. This will show the scope of these terms so that the context can be properly understood and then appropriately applied.
The Efficacy of Using Telehealth to Coach Parents of Children with Autism Spectrum Disorder on How to Use Naturalistic Teaching to Increase Mands, Tacts and Intraverbals
Authors: Ferguson Jenny , Dounavi Katerina , Craig Emma A. 
Published: July 2022

AbstractThere is a growing body of evidence supporting the use of telehealth to provide parent training in behaviour analytic interventions and researchers have begun to focus on international demonstrations of this model. The current study assessed the efficacy of a training package focused on naturalistic teaching strategies designed to upskill parents of children with autism spectrum disorder and provide them with ready to use strategies to increase social communication behaviours across verbal operants. Two parent–child dyads were trained to increase mand, tact and intraverbals during play. Parents displayed increases in fidelity for each strategy and viewed the training favourably. Both children showed gains across verbal operants, as captured by a multiple baseline across behaviours design.
Baby and us: Community-based, Feasibility Trial of a Psychosocial Intervention for New Parents and their Infants
Authors: Harwood Joshua , Fernández Leire , Vallejo Valentina , Day Crispin 
Published: July 2022

AbstractInfancy is a critical period during which major developmental transformations occur. Early parenting is one of the strongest influences on infants’ immediate and longer-term outcomes. The transition to parenting can be demanding and stressful for mothers and fathers. This paper reports results from a feasibility study of the Empowering Parents Empowering Communities Baby and Us programme, an 8-week, universal, peer-led parenting programme for new parents living in socially disadvantaged communities. This study is a quasi-experimental, one arm, no control group study, assessing the feasibility and acceptability of Baby and Us. Programme participants (n = 158) completed standardised self-report measures of parent goal attainment, self-efficacy, knowledge about parenting, mental wellbeing, parental confidence, and programme acceptability. We found that recruiting parents from disadvantaged backgrounds was feasible (96% of programmes recruited sufficient parents to proceed, mean = 6.6 parents per programme); parent goals closely matched the aims of the programme; programme completion was high (74%), and self-report measurement completion rates were in line with other large scale community delivered parenting programmes; parents rated the programme as highly satisfactory; and they reported significant improvements in their mental wellbeing, confidence, parenting skills, self-efficacy, and goal attainment. These results provide important data to conduct a full-scale trial of Baby and Us.