bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of methods for collecting hematopoietic stem cells in patients with malignant neoplasms weighing up to 15 kg and early age
Authors: Stepanyan N. G. , Matinyan N. V. , Slinin A. S. , Sagoyan G. B. , Palladina A. D. , Rubanskaya M. V. , Sidorova N. V. , Machneva E. B. , Kirgizov K. I. , Varfolomeeva S. R. 
Published: May 2022

Relevance. Autologous hematopoietic stem cell transplantation (auto-HSCT) is an integral part of the treatment of patients with high-risk malignancies. However, carrying out the mobilization and collection of hematopoietic stem cells (HSC) for patients weighing up to 15 kg is a complex task that requires a special approach and multidisciplinary interaction.The purpose of the studyis to present the experience of collecting HSC in young children weighing up to 15 kg at the Research Institute of Pediatric Oncology and Hematology of the Federal State Budgetary Institution N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia.Materials and methods. The study included 30 patients weighing up to 15 kg who received treatment from January 2020 to May 2021 at the Research Institute of Pediatric Oncology and Hematology of the Federal State Budgetary Institution N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia. Median age was 30.6 (12–48) months, median body weight was 12.2 (7.8–15) kg. Apheresis in children weighing up to 15 kg was performed in the resuscitation and intensive care unit with the condition of pre-filling the cell separator circuit with a donor irradiated erythrocyte suspension to prevent hypovolemic complications. Thirty two apheresis was performed on a cell separator of the “Spectra Optia” type. To mobilize HSC, preparations of granulocyte colony-stimulating factor with the main active ingredient filgrastim were used.Results. Twenty eight HSC apheresis procedures were successful on the first attempt, 2 patients underwent repeated apheresis (a total of 32 procedures were performed). The median number of CD34+cells obtained was 13.9 × 106/kg (0.04–92.0 × 106/kg), and the median apheresis duration was 251 (160–415) min. In 2 children during the procedure, an immediate organization of repeated venous access was required.Conclusions. Performing HSC apheresis in children weighing up to 15 kg and young children is a safe and effective technique with the participation of a multidisciplinary team. The apheresis algorithm proposed by us makes it possible to carry out a high-quality collection of CD34+cells, sufficient for auto-HSCT.
A spectrum of overgrowth syndromes associated with the <i>PIK3CA</i> mutation. Literature review
Authors: Sagoyan G. B. , Kletskaya I. S. , Imyanitov E. N. , Mareeva Yu. M. , Zhukov N. V. , Khagurov R. A. , Suleymanova A. M. 
Published: May 2022

PIK3CA-Related Overgrowth Spectrum (PROS) refers to rare syndromes, which are characterized by malformations and excessive tissue growth and caused by somatic mutations in the PIK3CA gene occurring during embryogenesis. This article discusses the pathogenesis, clinical picture, diagnosis and treatment of these syndromes.Some of the illustrations used in this article are copied from other resources, the rights of the authors are respected and not violated. The appropriate permissions from the journals have been obtained.
Mortality in the Volgograd Region Against the COVID-19 Pandemic
Authors: Alpatov A. V. 
Published: May 2022

The COVID-19 pandemic, which began in Russia in March 2020, had a huge impact on socio-economic processes. In numerous studies analyzing mortality caused by coronavirus infection, it is concluded that the number of deaths is underestimated. The high morbidity and mortality caused by coronavirus infection has far-reaching consequences for the economy of the regions and the country as a whole: deterioration in health, a decrease in the working-age population, a change in the structure of consumption of goods and services, etc. In this regard, it is relevant to analyze the processes associated with mortality from coronavirus infection.The purpose of the study is to identify the main trends in the nosological and age-sex structure of mortality in the Volgograd region in the years preceding the COVID-19 pandemic, to assess the contribution of mortality from coronavirus infection to total mortality in 2020. Estimation of excess mortality was carried out taking into account the dynamics of age-specific mortality rates.Materials and methods. The main sources of information for the study of mortality were the Russian database on fertility and mortality and Rosstat data. In the work, when analyzing mortality from COVID-19, data from the operational headquarters were also used. The analysis of the mortality dynamics was carried out using such indicators as the average life expectancy at birth, the crude death-rate, age-specific mortality rates in absolute and relative (per 1000 people) terms. The processing of statistical data was carried out using the Microsoft Excel application package and matplotlib, pandas, numpy (Python programming language), pyramid (R programming language) libraries.Results. In 2020, the number of deaths in the Volgograd region turned out to be more than in 2019 by 6647 people. If the trends in the dynamics of the intensity of mortality would persist in the year of the pandemic, then the total number of deaths in the Volgograd region would be equal to 32044 people. In this case, the excess mortality would have amounted to 7368 people.Conclusion. As a result of the study, it was revealed that a significant increase in the number of deaths in the Volgograd region during the pandemic is explained by Rosstat as the cause of coronavirus infection by only 33.2%. This discrepancy may be the result of incorrect accounting of deaths from coronavirus infection. Another factor in the increase in mortality during a pandemic may be a decrease in the quality of medical care. There has been a reorientation of the work of medical institutions to the treatment of patients with coronavirus infection; the burden on emergency medical care has increased.
Development of a Mobile Assessment Tool for Understanding Social Comparison Processes Among Individuals With Schizophrenia: Two-Phase Survey Study
Authors: Arigo Danielle , Torous John 
Published: May 2022

Background
Digital tools may help to address social deficits in schizophrenia, particularly those that engage social comparison processes (ie, evaluating oneself relative to others). Yet, little is known about social comparison processes in schizophrenia or how best to capture between- versus within-person variability, which is critical to engaging comparisons in digital interventions.

Objective
The goals of this pilot study were to (1) better understand affective responses to social comparisons among individuals with schizophrenia, relative to healthy controls, using a validated global self-report measure; and (2) test a new brief, mobile assessment of affective responses to social comparison among individuals with schizophrenia, relative to the full measure. This study was conducted in 2 phases.

Methods
We first compared self-reported affective responses to social comparisons between individuals with schizophrenia (n=39) and healthy controls (n=38) using a traditional self-report measure, at 2 time points. We examined the temporal stability in responses and differences between groups. We then evaluated the performance of brief, mobile assessment of comparison responses among individuals with schizophrenia, completed over 12 weeks (n=31).

Results
Individuals with schizophrenia showed greater variability in affective responses to social comparison than controls on traditional measures and completed an average of 7.46 mobile assessments over 12 weeks. Mobile assessments captured within-person variability in affective responses in the natural environment (intraclass correlation coefficients of 0.40-0.60). Average scores for mobile assessments were positively correlated with responses to traditional measures.

Conclusions
Affective responses to social comparison vary both between and within individuals with schizophrenia and capturing this variability via smartphone surveys shows some evidence of feasibility. As affective variability is a potential indicator of poor outcomes among individuals with mental health conditions, in the future, a brief, mobile assessment of affective responses to social comparisons may be useful for screening among individuals with schizophrenia. Further research on this process is needed to identify when specific comparison messaging may be most effective in digital interventions and could suggest new therapeutic targets for illnesses such as schizophrenia.
Self-efficacy and Use of Digital Health Care and Social Welfare Services Among Incarcerated People: Cross-sectional Survey Study
Authors: Rantanen Teemu , Järveläinen Eeva , Leppälahti Teppo 
Published: May 2022

Background
The digitization of health care and social welfare services creates many opportunities for the rehabilitation of incarcerated people and their preparation for release from prison. A range of digital platforms and technology solutions have been developed that offer multiple opportunities to handle private matters either by video conference, email, or some other digital format during imprisonment. However, incarcerated people have limited access to digital health care and social welfare services, and face challenges related to shortcomings in their digital skills and self-efficacy.

Objective
This article assessed the significance of incarcerated people’s self-efficacy in terms of their sense of control over the use of digital health care and social welfare services.

Methods
A cross-sectional study was conducted using a questionnaire. Research data were collected from 11 prisons in different parts of Finland, and a total of 225 incarcerated people responded to the survey. Statistical analyses were conducted using the Pearson product-moment correlation coefficient, 2-tailed t test, linear regression analysis, and Hayes bootstrapping method.

Results
The results showed the significance of both general and internet-specific self-efficacy, which appear to be more important for the use of digital health care and social welfare services than factors related to a person’s socioeconomic background or sentence. Age was negatively correlated with perceived control over the use of digital health care and social welfare services. Furthermore, the study emphasized the importance of support from family and friends, as well as prison employees.

Conclusions
The digitalization of prisons offers many opportunities, but special consideration should be given to how the digitization of health care and social welfare services responds to the needs of incarcerated people in terms of their integration into society and the prevention of recidivism. During imprisonment, attention should be paid to strengthening the digital skills of incarcerated people, with support provided by prison employees. In addition to providing guidance on the use of individual digital services, the study recommends strengthening the general digital skills of incarcerated people, as well as developing their life management skills.
Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study
Authors: Hirabayashi Naoki , Hata Jun , Furuta Yoshihiko , Ohara Tomoyuki , Shibata Mao , Hirakawa Yoichiro , Yamashita Fumio , Yoshihara Kazufumi , Kitazono Takanari , Sudo Nobuyuki , Ninomiya Toshiharu 
Published: May 2022

OBJECTIVE
To examine the association between diabetes and gray matter atrophy patterns in a general older Japanese population.

RESEARCH DESIGN AND METHODS
In 2012, a total of 1,189 community-dwelling Japanese aged ≥65 years underwent brain MRI scans. Regional gray matter volumes (GMV) and intracranial volume (ICV) were measured by applying voxel-based morphometry (VBM) methods. The associations of diabetes and related parameters with the regional GMV/ICV were examined using an ANCOVA. The regional gray matter atrophy patterns in the subjects with diabetes or elevated fasting plasma glucose (FPG) or 2-h postload glucose (2hPG) levels were investigated using VBM.

RESULTS
Subjects with diabetes had significantly lower mean values of GMV/ICV in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than subjects without diabetes after adjusting for potential confounders. A longer duration of diabetes was also significantly associated with lower mean values of GMV/ICV in these brain regions. The multivariable-adjusted mean values of the temporal, insular, and deep GMV/ICV decreased significantly with elevating 2hPG levels, whereas higher FPG levels were not significantly associated with GMV/ICV of any brain regions. In the VBM analysis, diabetes was associated with gray matter atrophy in the bilateral superior temporal gyri, right middle temporal gyrus, left inferior temporal gyrus, right middle frontal gyrus, bilateral thalami, right caudate, and right cerebellum.

CONCLUSIONS
The current study suggests that a longer duration of diabetes and elevated 2hPG levels are significant risk factors for gray matter atrophy in various brain regions.
Reliability of Class II Bulk-fill Composite Restorations With and Without Veneering: A Two-year Randomized Clinical Control Study
Authors: Kaisarly D , ElGezawi M , Haridy R , Elembaby A , Aldegheishem A , Alsheikh R , Almulhim KS 
Published: May 2022

SUMMARY
Bulk-fill composites are increasingly used in stress-bearing areas in posterior teeth, with a diversity of reports concerning their effectiveness and clinical reliability. The objective of this randomized clinical control study was to investigate the effectiveness of bulk-fill versus veneered bulk-fill Class II composite restorations. A double-blind split-mouth technique was employed in 80 subjects recruited for restoring Class II caries in one molar bilaterally in the same arch following respective inclusion and exclusion criteria and after obtaining written consent. While one molar was randomly restored with bulk-fill composite using the sealed-envelope technique, Tetric N-Ceram Bulk Fill (TBF), the contralateral was restored with a bulk-fill composite veneered with an increment of a heavy-body microhybrid composite—Tetric-Ceram HB (TBF/V). Box-only cavities were prepared and received etch-and-rinse adhesive bonding and Tetric N-Bond treatment before composite insertion. Restorations were assessed at 24 hours, 2 weeks, 6 months, 12 months, and 24 months for esthetic, functional, and biological quality employing the FDI ranking criteria. Friedman repeated-measures analysis of variance, the McNemar test, and the Cohen’s kappa statistical test were used for statistical analysis. Over a 24-month interval, none of the test restorations were ranked as clinically unsatisfactory. In terms of functional criteria, clinically excellent restorations were significantly more prevalent in TBF/V than in TBF (p&lt;0.05). For long-term satisfactory performance of Class II bulk-fill composites, an occlusal veneering increment of conventional heavy body microhybrid composite appears to be favorable.
Efficacy of Chlorhexidine Intracanal Medicament on Periodontal Healing in Concomitant Endodontic-Periodontal Disease with Communication: A Randomized Clinical Trial
Authors: Sharma Anuradha , Tewari Shikha , Tewari Sanjay , Sharma Rajinder Kumar , Narula Satish Chander , Gaur Ankit 
Published: May 2022

Background: Chlorhexidine has been extensively used in various periodontal and endodontic infections. However its use in combined endo perio lesion has not been defined clearly. The aim of this study was to evaluate the efficacy and synergistic effect of chlorhexidine intra canal medicament with combination of comprehensive periodontal therapy in endodontic periodontal lesions.
Materials and Methods: The patients were randomly assigned group 1 and group 2. Both the groups were treated by phase 1 and phase 2 periodontal treatments while group 1patients received conventional root canal treatment and group 2 patients were treated by chlorhexidine intracanal medicament for 6 months. The primary outcome measures are probing pocket depth, relative attachment level and bleeding on probing.
Results: Both groups showed improvement on primary outcome measures. However, group 2 showed significant more reduction in probing pocket depth (PPD) and bleeding on probing (BOP) and gain in relative attachment level (RAL) after complete 6 months treatment with chlorhexidine. Postoperative measurements from group1 and group 2 showed reductions in mean PPD of 2.63±0.98 and 3.57±1.13 mm, mean BOP reduction of 76.78±31.41and 87.54±22.35 and mean RAL gains of 2.42±1.27 and 3.42±0.94 mm, respectively.
Conclusion: 2% CHX gel used as an intracanal medicament along with periodontal treatment demonstrated more favourable treatment response in terms of periodontal healing.
Familial Aggregation Pattern of Non-Syndromic Combined Aplasia of Maxillary Lateral Incisors and Third Molars
Authors: Albu Cristina-Crenguta , Bencze Maria-Angelica , Dragomirescu Anca-Oana , Vlădan Cristian , Albu Ştefan-Dimitrie , Stanciu Ioana-Andreea , Pavlovici Romina-Christiana , Ionescu Ecaterina 
Published: May 2022

Congenitally missing teeth, the most common dental anomaly, refers to teeth whose germ did not develop sufficiently to allow the differentiation of the dental tissues.
This study aimed to determine the importance of genetic investigations on oral health-related quality of life in children with congenitally missing lateral incisors.
We are presenting a genetic study performed by the A.S. Division of Medical Genetics, in Bucharest, Romania, in the case of a patient (16-year-old boy) presenting bilateral maxillary lateral incisor agenesis in the permanent dentition, a hereditary, non-syndromic familial hypodontia in three successive generations, which suggest an autosomal dominant inheritance, combined with aplasia of maxillary third molars.
The oral visual examination and the radiological exam of the patient were completed with the oral photographic examination, the family historyinvestigation, the pedigree, and the analysis of the studied family’s genealogical tree, after acquiring the signed informed consent of the patient.
The genetic investigations of the congenitally missing lateral incisors, allow the calculation of the anomaly recurrence risk amongst offspring, and the direct and specialized monitoring of affected families, in order to limit the potential complications.
Source Rock Evaluation of Shale in Parts of Ini Local Government Area, Akwa Ibom State, Southeastern Niger Delta Basin, Nigeria
Authors: Asuaiko Ekpedeme R. , Bassey Clement E. , Harry Thomas A. , Owoeye Tejumade A. , Ibanga Veronica E. 
Published: May 2022

Total organic carbon and Rock – Eval pyrolysis studies were conducted on seven (7) shale samples outcropping in parts of Ini Local Government Area of Akwa Ibom State, Southeastern Niger Delta, Nigeria. The studies were done to determine the quantity and quality of organic matter in the shale source rock, and their hydrocarbon generation potential. Total organic carbon (TOC) values indicate poor to excellent organic richness with values ranging from 0.46 wt.% to 5.98 wt.%. The free oil content (S1) values range from 0.02-0.21 mg HC/g rock, (mean = 0.07 mg HC/g rock), while the source rock potential (S2) ranges from 0.08-1.09 mg HC/g rock with an average value of 0.45 mg HC/g rock both indicating poor source rock generative potential. The Hydrogen Index (HI) and the Oxygen Index (OI) range from 11 mg HC/g TOC to 59 mg HC/g TOC and 41 mg CO/g TOC to 74 mg CO/g TOC with an average value of 27.28 mg HC/g TOC and 55.71 mg CO/g TOC respectively. HI versus OI and S2 versus TOC cross plot results indicate that shale in parts of Ini Local Government Area contains organic matter capable of generating kerogen type III to type 1V which is gas prone.
Panorama dos alunos de educação em tempo integral no brasil
Authors: De Freitas Barros Gabriela Thamara , De Oliveira Adolfo Samuel 
Published: May 2022

O objetivo deste estudo é traçar um panorama dos alunos de educação em tempo integral (ETI) no Brasil, transcorridos cinco anos do Plano Nacional de Educação (PNE) – 2014/2019 –, e se apresenta como a continuidade da publicação: “Panorama das escolas de educação em tempo integral no Brasil: proposta de análise das estratégias da Meta 6 do PNE no período de 2014/2019”. Os resultados relacionados aos alunos são apresentados desagregados por etapas da educação básica e por redes de ensino (públicas e privada). As análises se apoiam em um conjunto de variáveis demográficas e socioespaciais e são apresentadas neste trabalho para o Brasil, porém, nas planilhas que acompanham o estudo, há também dados de unidades da Federação e municípios. Busca-se apontar caminhos para a análise da situação da ETI, com destaque para algumas de suas estratégias, conforme Meta 6 do PNE; subsidiar o aprimoramento ou a reorientação de programas e ações relativos à promoção equitativa da ETI nas escolas; e fornecer informações para os entes federativos utilizarem em suas conferências educacionais.
Download das planilhas
Comparison Different Estimation Methods for the Parameters of Non-Linear Regression
Authors: AdilabdAlkareem Zaid , Kalaf Bayda Atiya 
Published: May 2022

Nonlinear regression models are important tools for solving optimization problems. As traditional techniques would fail to reach satisfactory solutions for the parameter estimation problem. Hence, in this paper, the BAT algorithm to estimate the parameters of Nonlinear Regression models is used . The simulation study is considered to investigate the performance of the proposed algorithm with the maximum likelihood (MLE) and Least square (LS) methods. The results show that the Bat algorithm provides accurate estimation and it is satisfactory for the parameter estimation of the nonlinear regression models than MLE and LS methods depend on Mean Square error.
Optimal Control Problem To Robust Nonlinear Descriptor control Systems with Matching Condition
Authors: Zaboon Dr. Radhi Aliu 
Published: May 2022

Abstract
In this paper, the solutions to class of robust non-linear semi-explicit descriptor control systems with matching condition via optimal control strategy are obtained. The optimal control strategy has been introduced and developed in the sense that, the optimal control solution is robust solution to the given non-linear uncertain semi-explicit descriptor control system. The necessary mathematical proofs and remarks as well as discussions are also proposed. The present approach is step-by-step illustrated by application example to show its effectiveness a and efficiency to compensate the structure uncertainty in the given semi-explicit (descriptor) control system