bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the effect of yarrow (Achillea millefolium) on Ehrlich ascites tumor
Authors: Nisari Mustafa , İnanç Neriman , Tokpınar Adem , Al Özge , Uçar Sümeyye , Taştan Mustafa , Ateş Şükrü , Yılmaz Seher 
Published: October 2022

Abstract

Introduction
One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT).

Materials and Methods
The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours at 37°C in a shaking water bath. In the study, EAT cells were divided into control, DMSO group 5-FU, 50, 100, 200, 400 and 800 μg/ml YP groups.

Results
At the end of the hour, it was observed that total apoptosis increased significantly in Y groups (especially 50 μg/ml) compared to the control group (p<0.05). It was observed that Y slowed the division of EAT cells (especially 800 μg/ml) by stopping the cell cycle at the G0/G1 stage. It was concluded that Y (especially at high doses) triggered apoptosis by significantly increasing the percentage of total depolarized cells (p<0.001) in all three time periods.

Conclusions
The results obtained showed that Y extract may have an antitumoral effect on EAT cells. It is thought that this study will contribute to studies on cancer treatment.
The impact of type 2 diabetes duration on serum asymmetric dimethylarginine and C-reactive protein concentration in Bosnian patients
Authors: Zaciragic Asija , Dervisevic Amela , Avdagic Nesina , Babic Nermina , Valjevac Amina , Lepara Orhan , Huskic Jasminko 
Published: October 2022

Abstract

Objective. The present study assessed the impact of type 2 diabetes mellitus (T2DM) duration on the serum asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP) concentration in Bosnian patients.

Methods. Participants for this cross-sectional study were randomly selected from the Family Medicine Clinic (Sarajevo, Bosnia and Herzegovina). Serum ADMA concentration was determined by ELISA. Serum high-sensitivity (hs-CRP) was determined by particle-enhanced immunonephelometry. ANOVA test followed by Scheffe post-hoc test or Kruskal-Wallis test followed by Man-Whitney test were used for statistical analysis.

Results. The study included 38 patients in up to 10 years diabetes duration (≤10 years T2DM) group, 22 patients in greater than 10 years diabetes duration (>10 years T2DM) group, and 60 controls. Serum ADMA concentration in the >10 years T2DM group (1.81±0.15 μmol/L) was significantly higher compared to serum ADMA concentration in the ≤10 years T2DM group (1.38±0.41 μmol/L; p<0.001) and in controls (0.62±0.15 μmol/L; p<0.001). A significant difference in serum ADMA concentration was found between the <10 years T2DM group and the controls (p<0.001). The serum CRP concentration in the >10 years T2DM group [5.95 (4.20–9.12) mg/L] was significantly higher compared to serum CRP concentration in the <10 years T2DM group [2.35 (1.40–4.30) mg/L; p<0.001] and controls [0.85 (0.50–1.30) mg/L; p<0.001]. Significant difference in serum CRP concentration was observed between the <10 years T2DM group and controls (p<0.001).

Conclusions. The present study showed an increase in the serum ADMA and CRP concentrations with the advancement of T2DM. These results suggest that ADMA and CRP may serve as indicators of endothelial dysfunction and chronic low-grade inflammation progression in patients with T2DM. Larger prospective studies are required to confirm the observed findings.
Indo-French Comprehensive Bilateral Cooperation: A Roadmap to Indo-Pacific Parks Partnership and Beyond
Authors: Bharti Mukesh Shankar , Kumari Suprabha , Bharti Sushant Shankar 
Published: October 2022

Abstract

Subject and purpose of work: The purpose of this research is to the a ssess the Indo-French bilateral cooperation in the Indo-Pacific region. The study aims to identify the main areas of cooperation between India and France. This paper assesses a roadmap for the broader strategy for the „Indo-Pacific Parks Partnership”.

Materials and methods: It uses the empirical approach to know to what extent the Indo-French cooperation achieves its goal. Further, this study answers the following research questions to test a hypothesis. What kind of bilateral partnerships are the two countries shaping for deeper comprehensive cooperation? Why is the Indo-Pacific the central part of the Indo-French partnerships? India and France strategically shifted their bilateral partnership towards the Pacific and Indian Ocean regions for deeper cooperation.

Results: The bilateral partnership between India and France has been tremendously accelerating for the last decade. Both the countries are better attuned in the context of Maritime Security and trade cooperation in the Indo-Pacific region.

Conclusions: The article concludes that India and France need a deeper partnership in the Indo- Pacific region to accelerate trade and business in the maritime domain.
Green Bonds as an Opportunity to Rationalise Local-Government Finances
Authors: Milewska Anna 
Published: October 2022

Abstract

Subject and purpose of work: The purpose of the study was to identify the areas of activity of the local authorities in the context of the implementation of public tasks that could be financed with funds from the issue of the so-called green bonds.

Materials and methods: T he m ain r esearch method w as c ritical a nalysis of documents (using document of a normative nature and of various ranks) and the literature on broadly defined public finance and financial market issues. The individual case method, as well as inductive and deductive reasoning were also supportive in achieving the purpose of the study.

Results: The study presents areas related to the provision of public services and identifies those of them which represent negative environmental impact. The identified characteristics of public task entities included provide the premise for answering the question: will an instrument such as the ‘green bonds’ constitute a secure source of funding? The study shows the evolution of legislative changes relevant to the implementation of environmentally sustainable projects while presenting the benefits of their implementation.

Conclusions: The conclusions indicate the benefits of financing investments with funds from the issue of ‘green bonds’ for the budget of the local authority, the issuer and the bondholders.
JAK/STAT pathway targeting in primary Sjögren syndrome
Authors: Gandolfo Saviana , Ciccia Francesco 
Published: October 2022

Abstract
Primary Sjögren's syndrome (pSS) is an autoimmune systemic disease mainly affecting exocrine glands and resulting in disabling symptoms, as dry eye and dry mouth. Mechanisms underlying pSS pathogenesis are intricate, involving multiplanar and, at the same time, interlinked levels, e.g., genetic predisposition, epigenetic modifications and the dysregulation of both immune system and glandular-resident cellular pathways, mainly salivary gland epithelial cells. Unravelling the biological and molecular complexity of pSS is still a great challenge but much progress has been made in recent years in basic and translational research field, allowing the identification of potential novel targets for therapy development. Despite such promising novelties, however, none therapy has been specifically approved for pSS treatment until now. In recent years, growing evidence has supported the modulation of Janus kinases (JAK) - signal transducers and activators of transcription (STAT) pathways as treatment strategy immune mediated diseases. JAK-STAT pathway plays a crucial role in autoimmunity and systemic inflammation, being involved in signal pathways of many cytokines. This review aims to report the state-of-the-art about the role of JAK-STAT pathway in pSS, with particular focus on available research and clinical data regarding the use of JAK inhibitors in pSS.
The effect of Ulva rigida (C. Agardh, 1823) against cadmium-induced apoptosis and oxidative stress
Authors: İrkin Latife Ceyda 
Published: October 2022

Abstract
Cadmium (Cd) is known as a pollutant source in recent years with the increase in industrialization. Algae have secondary metabolites with high biological activity, used for pharmaceutical agents. The liver and kidney are the primary organs involved in the elimination of systemic cadmium and the main targets of cadmium toxicity. In the previous research, it was determined the ameliorative effects of the extract obtained from Ulva rigida in the liver tissue of rats induced by cadmium. 35 female Wistar rats between 225-240 g were used. The subjects were injected subcutaneously with 1 mg/kg cadmium chloride (CdCl2) four times a week for four weeks. The study was carried out by groups as control (G1), Cadmium group (1 mg/kg CdCl2-G2), Algae group (100 mg/kg-G3), Cd+algae group (1 mg/kg CdCl2+50 mg/kg algae extract-G4) and Cd+algae group (1 mg/kg CdCl2+100 mg/kg algae extract -G5). The subjects were sacrificed by cervical dislocation. Liver tissue and cardiac blood were collected. It was determined that oxidative stress with iNOS, inflammation and apoptosis with TNF-α increased with cadmium induction, while there was a statistically significant decrease in the groups that were given algae extract. In addition, biochemical changes in SOD, CAT and MDA values were found to be significant (p<0.05). As a result, it was determined that algae extract could play a protective role with its antioxidant and antiapoptotic properties in experimentally induced cadmium toxicity in rats.
Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation
Authors: Nemes-Nagy Enikő , Fogarasi Erzsébet , Croitoru Mircea Dumitru , Preg Zoltán , Pál Sándor , Nyulas Kinga-Ilona , Pál Tünde , Tripon Robert Gabriel , Tilinca Mariana Cornelia , Germán-Salló Márta 
Published: October 2022

Abstract

Introduction: Hypertension and diabetes mellitus affect a large number of patients and can significantly influence their life expectancy. Changes in metabolic and oxidative stress parameters are common in these pathologies, contributing to associated complications. The aim of the study was assessment of relationship between laboratory parameters and their role in evaluation of cardiovascular risk, and possible gender-related differences in the protective factors.

Material and methods: Blood samples were collected from hypertensive patients with/without diabetes mellitus admitted to the Cardiovascular Rehabilitation Clinic in Tîrgu Mureș and controls without these pathologies. Biochemical analyses were performed on Konelab analyzer (glycemia, lipid profile, kidney function tests, zinc, hsCRP). Oxidative stress markers, such as serum malondialdehyde (MDA), oxidized (GSSG) and reduced glutathione (GSH) were evaluated using an HPLC-UV/VIS technique at GEP UMPhST. Statistical analysis was performed by GraphPad InStat3.

Results: Mean age of hypertensive patients (n=131) was 69.44 ± 9.02 years, 45.8% males, 31.3% being diabetics. 74.1% of the studied patients had zinc deficiency, 19.8% presented slightly elevated hsCRP. The control group included 24 nonhypertensive/nondiabetic patients of similar age. Average GSH was significantly lower (p=0.0002) in hypertensive patients, 1.89 ± 0.82 µg/ml, compared to the control group (3.23 ± 0.49 µg/ml), and no correlation could be observed between GSH and MDA values. GSH concentration was significantly higher in males (p=0.0395) and HDL-cholesterol significantly higher in females (p=0.0132). A negative correlation was observed between serum triglyceride and HDL-cholesterol concentration.

Conclusions: Gender differences are present in the level of protective factors against cardiovascular diseases, while oxidative stress is intensified in hypertensive/diabetic patients.
Setting up an own laboratory performance-based internal quality control plan - a model for complete blood count
Authors: Oprea Oana R. , Preda Elena Cristina , Mănescu Ion Bogdan , Dobreanu Minodora 
Published: October 2022

Abstract
Quality Control (QC) in Romania is regulated by the Order of the Minister of Health no. 1608/2022 that modifies the previous Order 1301/2007. The new version of the Order introduces a more scientific approach by requesting the laboratories to assess test performance and then elaborate an appropriate internal QC plan. The aim of this study was to demonstrate how to design a QC plan for complete blood count (CBC) in an Emergency Laboratory with continuous activity, in order to comply with the new Order 1608/2022. QC data obtained over a three-month period (April-June 2022) from the Sysmex XN-1000 instrument of the Emergency Laboratory of the County Emergency Clinical Hospital of Târgu Mureș were included. In order to establish an appropriate QC plan, two models were applied and the following parameters were calculated: the number of daily QC runs (N), the probability of false rejection (Pfr), the QC frequency (run size), and the required QC rules. White blood cells achieved high performance, while Hematocrit performance was poor. Different levels of performance were achieved for Platelets. We emphasize that, when all parameters are measured on the same instrument, QC frequency and Pfr should be adjusted in order to develop a QC plan that “fits” all the parameters of the CBC as a whole. In our Emergency Laboratory, the calculated QC plan for CBC is N=2, Pfr=0.03, multi-rule 1:3s/2:2s/R:4s, and a run size of 95 samples which is approximately the same as the number of CBCs performed during one 12-hour shift.
READING STRATEGY TAXONOMIES: AN OVERVIEW
Authors: Thi Bich Thuy Nguyen 
Published: October 2022

The crucial importance of reading in any language has stimulated a noticeable growth in the number of studies on reading strategies used in second and foreign language reading to improve readers’ comprehension. This paper examined the classifications of reading strategies by providing a variety of reading strategy taxonomies by different authors. The comparisons of the most well-known reading strategy taxonomies by Oxford (1990) and three other best-known ones by O’Malley and Chamot (1990), Mokhtari and Sheorey (2002), and Oxford (2013) were also demonstrated clearly. Two questionnaires, one of which was modified by Nguyen (2016) from the one by Sheorey and Mokhtari (2002) were also presented as useful recommendations for researchers in the field. The results of the research offer a quite comprehensive insight into reading strategy taxonomies, which might be useful for researchers in the field of reading strategies in choosing an appropriate theoretical framework for their studies in the future.
مشاكل البيئة الطبيعية للثروة الحيوانية وتباينها المكاني في محافظة اربيل
Authors: Hermze al Nabati Poleen Polis 
Published: October 2022

يساهم الانتاج الحيواني بأنواعه مساهمة فعالة في توفير الموارد الغذائية اللازمة للإنسان, و لهذا فقد حظيت الدراسات الخاصة بالثروة الحيوانية و توزيعها و تباينها مكانيا اهتمامات معظم الباحثين في مختلف المجالات. يهدف البحث إلي ابراز أهم مشاكل البيئة الطبيعية التي تعاني منها الثروة الحيوانية في منطقة الدراسة والتي برزت من خلال صورة التباين المكاني لها في محافظة اربيل وبوجه الخصوص حيوانات الماشية (الاغنام والابقار والماعز ), و قد اعتمدت الدراسة على تباين العوامل الطبيعية بين مختلف الاقضية التابعة لهذه المحافظة كأساس للتباين المكاني فيها اضافة الي العوامل البشرية. حيث تعتبر الثروة الحيوانية من الموارد المرتبط وجودها المكاني بظواهر جغرافية معينة ,و قد حاول البحث اثبات صحة ذلك من خلال الاعتماد على بيانات اظهرت توزيع الماشية في منطقة الدراسة
الرواة الذين قال فيهم الإمام ابو حاتم الرازي(ت277هــ) ( صالح الحديث لا بأس به )
Authors: Attia Mahmoud Hussein 
Published: October 2022

حمل هذا البحث عنوان (الرواة الذين قال فيهم الإمام أبو حاتم الرازي (تـ 277هـ) (صالح الحديث لا بأس به) في كتابه الجرح والتعديل "جمع ودراسة نقدية ") وقد قسمته الى مبحثين وتحتها مطالب حسب حاجة البحث كالاتي: المبحث الاول مقسم الى مطلبين, الاول في حياة الإمام أبي حاتم الرازي الشخصية، والمطلب الثاني في حياته العلمية, والمبحث الثاني في الرواة الذين قال فيهم(صالح الحديث لا بأس به) ويتضمن مبحثين: الأول: في حياة الإمام أبي حاتم الرازي الشخصية، فيما جاء المبحث الثاني: في حياة الإمام أبي حاتم الرازي العلمية, ثم الخاتمة والنتائج، وبعدها المصادر والمراجع، ثم ملخص باللغة الإنكليزية.
التنوع السكاني في سوريا 1920-1946
Authors: Abdulla Salih Hassan , Khelil Ahmed Esmaal 
Published: October 2022

إن المجتمع السوري كسائر المجتمعات الأخرى بشكل عام والمجتمع العربي على نحو خاص، يتكون من مجاميع سكانية تختلف في انتماءاتها الدينية والمذهبية والاثنية، كما يختلفون في توزيعهم الجغرافي في البلاد السورية، بين بيئات مدنية وريفية وجبلية، الى جانب اختلاف احوالهم السياسية والاقتصادية والاجتماعية. تميز هذا التنوع الى حد كبير بالتفاهم والانسجام مع احترام خصوصيات كل فئة، واعتزاز كل طائفة او اقلية بانتمائها العرقي والديني واستمر هذا الوضع الى ان تغير بشكل واضح مع وقوع سوريا تحت الانتداب الفرنسي.
لقد بدى واضحاً ان سياسية الانتداب الفرنسي كانت في تذبذب واضح بين الحفاظ على وحدة سوريا من جهة، وتشجيع النزعات الانفصالية وتكريس الطائفية من جهة أخرى، يعود ذلك لطبيعة المصالح الفرنسية ومساراتها التي تتركز بشكل أساسي على التحكم والسيطرة في المجتمع السوري، ويدل ذلك ان خصوصية الطائفة هي من تحدد مسار سياسة الانتداب في سوريا عموماً.
حاول الانتداب نزع صفة المجتمع او الامة عن عموم السكان واستبدالها بتكريس مفهوم الكيانات الاثنية والطائفية، ورغم ان هذه السياسة تم مواجهتها من المجتمع السوري الا اننا لا يمكن ان ننكر ان حجم هذه المقاومة لم تكن بذات القوة لسياسة الانتداب الفرنسي ويعود ذلك الى أسباب عديدة سياسية واقتصادية وثقافية تراكمت جراء الوجود العثماني ثم الانتداب الفرنسي.
البيان في آيات الشرك ( دراسة بلاغية)
Authors: Fayyad Ali Abdul Razzaq , Wakaa Muthanna Ahmed , Abbas Saleh Sahib 
Published: October 2022

لم تكن علوم البلاغة (المعاني، والبيان، والبديع)، معروفة في العصر الجاهلي عند العرب، ولكن المروي في أدبهم الذي نقله العلماء يحمل في طياته ما يصور فصاحة لسانهم، وقوة بلاغتهم ، وكيف كانوا يجيدون القول بكل فنونه وبلاغته من تراكيب معنوية، ولطائف بيانية، وفنون بديعية، ولعل علم البيان الذي يخص بحثنا له اليد الطولى في الكشف عن مكامن الأسرار البلاغية، من تشبيهات بليغة، واستعارات لطيفة، وكنايات جميلة، ومجاز منتظم لغوي وعقلي وينقسم المجاز اللغوي إلى مجاز مرسل واستعارة، الذي كشفت لنا في سياقها ومقامها ما دلت علية آيات الشرك من اسرار بلاغية، لذلك أثرنا أن ندرس هذا الفن ضمن بحثنا الموسوم بـ( البيان في آيات الشرك في القرآن الكريم دراسة بلاغية ) للكشف عن الدلالات والمعاني التي تدل عليها النصوص القرآنية، والذي سأوجزه بمبحثين وخاتمة.
التأثير النفسي والإدراكي للألوان في الخرائط
Authors: Jasim Al Doori Sideeq Mustafa , Ali May Abed 
Published: October 2022

ترتكز دراستي الموسومة (التأثير النفسي والإدراكي للألوان) على محاولة معرفة مدى التأثير النفسي والإدراكي للألوان في حياة الإنسان بمختلف المستويات العمرية وباختلاف نوع الجنس وبحسب المستوى الثقافي للشخص، وتفسير دلالات الألوان ومعانيها، والتأثير السايكولوجي للألوان في حياة الإنسان، وذلك لأهمية الألوان في حياة الإنسان وتماسها المباشر به والذي يؤثر بدوره على اختياراته وانفعالاته وانعكاساتها على سلوكه، وتبين من نتائج البحث أن للألوان تأثيرا كبيرا في تلك السلوكيات وتلك الاختيارات، وانعكس التأثير حتى في المزاج والراحة النفسية وعدمها بالنسبة للإنسان، وكان التأثير متنوعا ومختلفا ما بين الفئات المختلفة من عيّنة الدراسة بالنسبة للألوان المفضلة على غيرها في كل فئة، فالاختلاف كان واضحا مابين كبار السن وصغار السن وما بين الذكور والإناث ومابين المستوى الثقافي العالي أو البسيط، فالألوان تترك في النفس البشرية انعكاسات كثيرة ومختلفة ولها الشأن الكبير في تحديد مدى قبول الإنسان أو رفضه لحالات في الحياة، سواء في التعلّم أو التركيز أو في فتح الشهية أو فقدانها أو في اختيار الملبس والأثاث والحاجات المختلفة التي تمس حياة الإنسان.
وتناولت الدراسة العين وآليات استقبالها للون وكيفية عملها التي تشبه إلى حد كبير آلية عمل الكاميرا الفوتوغرافية، وكذلك تناولت تشريح العين وكيفية تلقي الضوء، وتفسير الصورة المرئية، وتحليل الألوان في الدماغ، مما يوضح الجوانب النفسية والجسمية المتعلقة بالألوان.
الأوضاع السياسية والاقتصادية الداخلية في المملكة الأردنية الهاشمية 1988-1996
Authors: AL-Tikrity Harith A. , Daham Ayad Khalaf 
Published: October 2022

مرت المملكة الاردنية الهاشمية بمراحل تاريخية مختلفة ارتبطت بصورة كاملة بواقعها الاقتصادي ، واعتماده على المساعدات الدولية والاقليمية ، لذلك حاول الباحث الخوض في عرض الأحداث السياسية والاقتصادية التي مرت بها المملكة في محاولة لفهم التداخل والترابط بين الجانبين ومحاولة الإجابة عن العديد من التساؤلات التي عصفت بالحياة السياسية والتي طالما غيرت الوزارات المتعاقبة . لقد تم عرض الموضوع على أكثر من محمور ، كان الاول منها بعنوان الانعكاسات المحلية والاقليمية وأثرها في سير انتخابات 1989، أما المحور الثاني فقد خصص لدراسة برنامج التصحيح الاقتصادي ، في حين عرض المحور الثالث معوقات ومقومات السياسات الاقتصادية ، وقد ناقش المحور الرابع المؤتمرات الدولية والاقليمية وانعكاساتها على الاوضاع الداخلية 1994-1996 ، وأخيرا عالج المحور الخامس الازمة الاقتصادية عام 1996 .
Ethnic Cultural Codes in the Visual Semiosis of Crimea
Authors: Kotliar Elena Romanovna , Khlevnoi Vladimir Aleksandrovich 
Published: October 2022

The subject of the study is ethnic cultural codes that are broadcast in the visual semiosis of decorative and applied art and architecture of the Crimea. The object of the study is architecture and decorative and applied art of various ethnic groups of the Crimea. The research uses methods of semantic, semiotic and artistic analysis of traditional images, the method of analysis of previous studies, the method of synthesis in conclusions regarding the formation of a unified Crimean style in visual semiosis. In the study, the author considers aspects of the topic: morphology and semantics of the elements of the visual semiosis of the Crimea and their belonging to a particular code of ethnic cultures; polyethnicity in the formation of the Crimean style of architectural and subject decor. The emphasis is placed on the multiculturality of the Crimea in the process of forming a semiotic universe in the visual semiosis. The main conclusions of the study are: 1.	Crimea is a multicultural ecumene due to its geographical location, the interaction of ethnic groups on its territory generated various cultural processes, ranging from reception to integration, which led to the formation of a unique Crimean style in the visual arts. The elements of this style were the details of the ethnic art of various peoples who inhabited the Crimea from the first centuries of our era to the present. 2.	Ethnic cultural codes defining the identification of the presence of a certain national artistic culture in the unified Crimean semiosis of architecture and decorative and applied art are elements and symbols characteristic of the traditional semiosis of a particular ethnic group. Over time, they have changed and experienced mutual influence, but the most persistent of them are still identified as belonging to a certain national and/or religious culture. 3.	The scientific novelty of the research consists in the fact that the author for the first time conducts a semantic analysis of pictorial symbols in the visual semiosis of Crimea, identifies individual ethnic cultural codes, analyzes their genesis, commonality and differences of elements as part of a single Crimean stylistics.
ARCHITECTURAL PLACE IDENTITY – AUTHORIAL MEASUREMENT INDICATOR
Authors: Paulina Dudzik-Deko  , Rzeźnik Joanna 
Published: October 2022

Architectural place identity belongs to the historical and cultural heritage related to the landscape architecture. It has a great impact both on the observers’ perception of the given space and their emotional attitude as well. The aim of this article is to present an original method of measuring the architectural place identity , including a definition and clarification of the analyzed concept. The measurement indicator of the chosen phenomenon has been presented on the background of Wrocław and its urban public areas. The applied method allowed an examination of the analyzed issues in the given spatial range. The article comprises a complete , theoretical description of the research and reveals all the options of its use in practice.