bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons
Authors: Honoré Ève , Belo do Nascimento Inês , Laplante Isabel , Lacaille Jean-Claude 
Published: September 2022

AbstractSomatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs onto PC dendrites. Excitatory synapses from PCs onto SOM-INs (PC-SOM synapses) exhibit long-term potentiation (LTP) mediated by type 1a metabotropic glutamate receptors (mGluR1a). LTP at PC-SOM synapses translates in lasting regulation of metaplasticity of entorhinal and CA3 synaptic inputs on PCs and contributes to hippocampus-dependent learning. A persistent form of PC-SOM synapse LTP lasting hours is prevented by blockers of transcription and translation, and a more transient form of PC-SOM synapse LTP lasting tens of minutes requires mTORC1-signaling, suggesting an involvement of protein synthesis. However, the role of protein synthesis in these forms of plasticity has not been directly demonstrated. Here we use the SUrface SEnsing of Translation (SUnSET) assay of protein synthesis to directly show that the induction protocols for both forms of LTP at PC-SOM synapses stimulate protein synthesis in SOM-INs. Moreover, protein synthesis stimulated by persistent LTP induction was prevented in mice with a SOM-IN conditional knock-out of Raptor, an essential component of mTORC1, indicating a critical role of mTORC1 in the control of translation in PC-SOM synapse plasticity. Moreover, protein synthesis induced by both forms of LTP may share common mechanisms as transient LTP induction occluded further stimulation of protein synthesis by persistent LTP induction. Our findings highlight a crucial role of protein synthesis and its control by mTORC1 in SOM-INs that is important for hippocampus-dependent memory function.
Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis
Authors: Chanoch-Myers Rony , Wider Adi , Suva Mario L. , Tirosh Itay 
Published: September 2022

Abstract
Background
Multiple glioblastoma studies have described a mesenchymal (MES) state, with each study defining the MES program by distinct sets of genes and highlighting distinct functional associations, including both immune activation and suppression. These variable descriptions complicate our understanding of the MES state and its implications. Here, we hypothesize that there is a range of glioma MES states, possibly reflecting distinct prior states in which a MES program can be induced, and/or distinct mechanisms that induce the MES states in those cells.

Methods
We integrated multiple published single-cell and bulk RNA sequencing datasets and MES signatures to define a core MES program that recurs across studies, as well as multiple function-specific MES signatures that vary across MES cells. We then examined the co-occurrence of these signatures and their associations with genetic and microenvironmental features.

Results
Based on co-occurrence of MES signatures, we found three main variants of MES states: hypoxia-related (MES-Hyp), astrocyte-related (MES-Ast), and an intermediate state. Notably, the MES states are differentially associated with genetic and microenvironmental features. MES-Hyp is preferentially associated with NF1 deletion, overall macrophage abundance, a high macrophage/microglia ratio, and M2-related macrophages, consistent with previous studies that associated MES with immune suppression. In contrast, MES-Ast is associated with T cell abundance and cytotoxicity, consistent with immune activation through expression of MHC-I/II.

Conclusions
Diverse MES states occur in glioblastoma. These states share a subset of core genes but differ primarily in their association with hypoxia vs. astrocytic expression programs, and with immune suppression vs. activation, respectively.
The association between dietary insulin index and load with mental health
Authors: Darand Mina , Amirinejad Ali , Salehi-Abargouei Amin , Davies Ian G. , Mirzaei Masoud , Mazidi Mohsen , Khayyatzadeh Sayyed Saeid 
Published: September 2022

Abstract
Background
Depression, anxiety, and stress are common mental problems. The aim of this cross-sectional study was to investigate the association between two indexes that measure postprandial insulin response to different food, dietary insulin index (DII) and insulin load (DIL), with psychological disorders.

Method
Participants (n = 10,000) aged 20–69 were randomly selected from 200 clusters in Yazd from the recruitment phase of the Yazd Health Study. The dietary intake of participants was collected by a reliable and validated food frequency questionnaire (FFQ) consisting of 178 food items. DII and DIL were calculated from the FFQ data using previously published reference values. To assess psychological disorders an Iranian validated short version of a self-reported questionnaire (Depression Anxiety Stress Scales 21 [DASS21]) was used.

Results
No significant association was observed between DIL and DII with odds of depression or anxiety using crude or adjusted models. However, individuals in the highest quartiles of DIL had the lowest odds of stress (OR: 0.69; 95% CI 0.48–1.01, P-trend = 0.047). This association remained significant after adjustment for potential confounders in model II including marital status, smoking, education, job status, salt intake, and multi-vitamin supplement use (OR: 0.38; 95% CI 0.16–0.91, P-trend = 0.039) and the third and final model which is further adjusted for BMI (OR: 0.39; 95% CI 0.16–0.91, P-trend = 0.041).

Conclusion
Overall, consumption of foods with higher DII as well as DIL were associated with lower stress scores; however, no significant relationship was observed between DII or DIL with respective depression or anxiety scores.
Religious affiliation seldom seems to influence hiring or competence ratings of job applicants: studies conducted in Sweden and in the USA
Authors: Hallin Nathalie , Västfjäll Daniel , Andersson Gerhard 
Published: September 2022

Abstract
Background
Religion is an important ingroup characteristic for many people. For different reasons, people with different religious affiliations might prefer members of their religious outgroup. Previous studies have investigated perceptions of and behaviour toward religious ingroup and outgroup members in various contexts. The four studies presented here investigated whether competence and likeability ratings differ depending on the target’s and participant’s religious affiliations in a recruitment context. Two studies were conducted in Sweden, while the other two were conducted in the USA.

Methods
Participants in 4 studies rated a Christian, Muslim or atheist job applicant and a control applicant on 4 competence and 3 likeability items on 7-point Likert scales. The difference in ratings between the target applicant and control applicant was used to measure perceived competence and likeability of the target applicant. In the two latter studies, one in Sweden and one in the USA, participants also chose to hire either the target or the control applicant.

Results
Overall, participants in three studies rated control applicants as more likeable than target applicants. In the two US studies, targets were also rated as less competent than control applicants. Christian participants in the two US studies rated the Christian applicant as more likeable than both other targets. In the second US study, atheist participants rated Christians as less likeable than both other targets. In one of the Swedish studies, atheist participants rated the atheist applicant as more likeable than both other targets. The only significant difference in competence ratings between targets was made by Christian Swedes, who rated Muslim applicants as less competent than Christian applicants. The only significant difference in hiring decisions was that Swedish atheist participants hired Christians less often than they hired control applicants.

Conclusion
Together, the results suggest that job applicants are sometimes viewed as more likeable if they belong to a religious ingroup rather than a religious outgroup, but that this only rarely translate to significant differences in competence ratings or hiring decisions.
TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome
Authors: Perez-Rivas Luis Gustavo , Simon Julia , Albani Adriana , Tang Sicheng , Roeber Sigrun , Assié Guillaume , Deutschbein Timo , Fassnacht Martin , Gadelha Monica R. , Hermus Ad R. , Stalla Günter K. , Tichomirowa Maria A. , Rotermund Roman , Flitsch Jörg , Buchfelder Michael , Nasi-Kordhishti Isabella , Honegger Jürgen , Thorsteinsdottir Jun , Saeger Wolfgang , Herms Jochen , Reincke Martin , Theodoropoulou Marily 
Published: September 2022

AbstractCorticotroph macroadenomas are rare but difficult to manage intracranial neoplasms. Mutations in the two Cushing’s disease mutational hotspots USP8 and USP48 are less frequent in corticotroph macroadenomas and invasive tumors. There is evidence that TP53 mutations are not as rare as previously thought in these tumors. The aim of this study was to determine the prevalence of TP53 mutations in corticotroph tumors, with emphasis on macroadenomas, and their possible association with clinical and tumor characteristics. To this end, the entire TP53 coding region was sequenced in 86 functional corticotroph tumors (61 USP8 wild type; 66 macroadenomas) and the clinical characteristics of patients with TP53 mutant tumors were compared with TP53/USP8 wild type and USP8 mutant tumors. We found pathogenic TP53 variants in 9 corticotroph tumors (all macroadenomas and USP8 wild type). TP53 mutant tumors represented 14% of all functional corticotroph macroadenomas and 24% of all invasive tumors, were significantly larger and invasive, and had higher Ki67 indices and Knosp grades compared to wild type tumors. Patients with TP53 mutant tumors had undergone more therapeutic interventions, including radiation and bilateral adrenalectomy. In conclusion, pathogenic TP53 variants are more frequent than expected, representing a relevant amount of functional corticotroph macroadenomas and invasive tumors. TP53 mutations associated with more aggressive tumor features and difficult to manage disease.
THE INTERNET AS A MEANS OF SEARCHING JOBS AND STAFF
Authors: Skripnichenko L. 
Published: September 2022

In order to determine the real level of interaction between applicants and employers using Internet resources within the framework of the electronic labor market, an analysis of the allocated communication channels in the labor market was carried out. It turned out that today most large companies and job seekers in the labor market resort to the use of Internet resources. Meanwhile, the study of modern realities proves that this tool is not fully disclosed in practice.
The results of the study revealed the following: companies use the capabilities of their own sites in different ways; the use of modern specialized work sites is built into the strategy of filling vacancies not by all organizations, while the functionality of the sites themselves is limited; despite the high attendance of applicants for social networks, the mechanism of using the latter as a channel of interaction in the labor market is at the formation stage.
Best of Both Worlds Ad Contracts: Guaranteed Allocation and Price with Programmatic Efficiency
Authors: Cohen Maxime C. , Désir Antoine , Korula Nitish , Sivan Balasubramanian 
Published: September 2022

Buying display ad impressions via real-time auctions comes with significant allocation and price uncertainties. We design and analyze a contract that mitigates this uncertainty risk by providing guaranteed allocation and prices while maintaining the efficiency of buying in an auction. We study how risk aversion affects the desire for guarantees and how to price a guaranteed allocation. We propose to augment the traditional auction with a programmatic purchase option (which we call a Market-Maker contract) that removes allocation and price uncertainties. Instead of participating in the auction, advertisers can secure impressions in advance at a fixed premium price offered by the Market-Maker. It is then the responsibility of the Market-Maker to procure these impressions by bidding in the auction. We model buyers as risk-averse agents and analyze the equilibrium outcome when buyers face two purchase options (auction and Market-Maker contract). We derive analytical expressions for the Market-Maker price that reveal insightful relationships with uncertainties in the auction price and buyers’ risk levels. We also show the existence of a Market-Maker price that simultaneously improves the seller’s revenue and the sum of buyers’ utilities. As a building block to our analysis, we establish the truthfulness of the multiunit auction when buyers have nonquasilinear utilities because of risk aversion. Recently, the Google’s Display & Video 360 platform started offering a product akin to Market-Maker called “Guaranteed Packages,” which was inspired by this paper. This paper was accepted by Gabriel Weintraub, revenue management and market analytics. Funding: The authors thank Google Research for its generous support.
Superfast and large-depth-range sinusoidal fringe generation for multi-dimensional information sensing
Authors: Zhu Sijie , Wu Zhoujie , Zhang Jing , Zhang Qican , Wang Yajun 
Published: September 2022

Among many multi-dimensional information sensing methods such as structured-light and single-pixel imaging technologies, sinusoidal fringe generation is general and crucial. Current methods of sinusoidal fringe generation force concessions in either the speed or the depth range. To mitigate this trade-off, we have simultaneously achieved both speed breakthrough and depth range enhancement by improving both the optical projection system and binary coding algorithm based on an off-the-shelf projector. Specifically, we propose a multifocal projection system and oblique projection method, which essentially eliminates the existence of a single focal plane in the conventional axisymmetric system and utilizes its anisotropy characteristics to achieve a superior filtering effect. Furthermore, the optimal pulse width modulation technique is introduced to modulate the square binary pattern for eliminating specific harmonics. To the best of our knowledge, the proposed method, for the first time, simultaneously achieved superfast (9524 frames per second) and large-depth-range (560 mm, about three times that of the conventional method) sinusoidal fringe generation with consistently high accuracy. Experimental results demonstrate the superior performance of the proposed method in multi-dimensional information sensing such as 3D, 4D, and [

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Comparing the effectiveness and safety of Abatacept and Tocilizumab in elderly patients with rheumatoid arthritis
Authors: Temmoku Jumpei , Miyata Masayuki , Suzuki Eiji , Sumichika Yuya , Saito Kenji , Yoshida Shuhei , Matsumoto Haruki , Fujita Yuya , Matsuoka Naoki , Asano Tomoyuki , Sato Shuzo , Watanabe Hiroshi , Migita Kiyoshi 
Published: September 2022

Background
The number of biological DMARDs (bDMARDs) used in elderly patients with rheumatoid arthritis (RA) has increased in recent years. We aimed to compare the drug retention rates and safety of abatacept (ABT) and tocilizumab (TCZ) in elderly patients with RA.

Methods
A total 125 elderly patients with RA (>65 years) who began therapy with either ABT (n = 47) or TCZ (n = 78) between 2014 and 2021 at our institute were enrolled. We compared the drug retention rate and clinical response at 24 weeks between elderly patients with RA treated with ABT and those treated with TCZ. Adverse events (AEs) and the reasons for drug discontinuation were assessed.

Results
There was no significant difference in demographic characteristics except for the use of glucocorticoid between the ABT and TCZ groups. There was no significant difference in the drug retention rate between the ABT and TCZ groups. Furthermore, there was no significant difference in the discontinuation rates due to the lack of effectiveness between these two groups. The proportions of the patients archiving low disease activity at 24 weeks did not differ significantly between the two groups. Whereas, the discontinuation rates due to AEs, including interstitial lung disease (ILD), seemed higher in the TCZ group than in the ABT group. In TCZ-treated group, the concomitant use of methotrexate (MTX) significantly increased the incidences of AEs leading to the discontinuation of TCZ. Whereas these was no significant impact of concomitant use of MTX on the incidences of AEs leading to discontinuation in ABT-treated group.

Conclusions
In elderly patients with RA treated with ABT and TCZ, drug retention rates were equivalent between the two groups. There were some differences in safety profiles between ABT and TCZ, and the rates of discontinuation due to AEs, including ILD, seem to be lower with ABT than with TCZ in elderly patients with RA.
Bioequivalence of micronutrient powders to Corn-soy Blend on serum zinc concentration of children (6–36 months) with Moderate Acute Malnutrition in Thika urban slums, Kenya: A cluster-randomized controlled trial
Authors: Kiio Juliana , Ochola Sophie , Nduati Ruth , Kuria Elizabeth , Mathenge Scholastica , Okoth Judith 
Published: September 2022

Zinc deficiency is common among children with Moderate Acute Malnutrition (MAM) and contributes to growth failure, increased morbidity and mortality. Diarrhoea and poor dietary practices are the main causes of zinc deficiency. Corn-soy Blend (CSB), the standard product in management of children with MAM has a limitation of poor micronutrient bioavailability. Micronutrient powders (MNPs) which are added at the point of consumption have a potential in improving micronutrient status however, scientific evidence on efficacy on improving the zinc status is scarce. A cluster-randomized clinical trial was designed to establish bioequivalence of MNPs to CSB on serum zinc status among children (6–36 months) with MAM in Thika informal settlements, Kenya. Sample size was calculated to show bioequivalence within ±20% limit. Twelve villages were randomized to four study groups. Three experimental groups received different formulations of MNPs added to unfortified CSB porridge as; multiple micronutrients containing zinc (CSB-MNP-A n = 84), multiple micronutrients without zinc (CSB-MNP-B n = 88) and zinc only (CSB-MNP-C n = 94). Control group (n = 80) received standard CSB fortified with multiple micronutrients. Standard amount of CSB was consumed in feeding centres for six months. Serum zinc concentration was assessed pre- and post-intervention. Data was analyzed based on treatment assignment regardless of adherence and drop-out status. Mixed effects linear regression was used to model pre-post change in serum zinc concentration, adjusting for clustering effect and baseline differences. Bioequivalence was assessed using two one-sided t-tests. At baseline, 84.4% were zinc deficient (serum zinc <65μg/dL) and zinc intake was sub-optimal (<3 mg/day) for 95.7% of children. Mean change in serum zinc concentration was significantly higher (p = 0.024) in CSB-MNP-A (18.7 ± 2.1) μg/dL compared to control group (11.8 ± 2.6 μg/dL). MNPs are not bioequivalent to CSB within the ±20% bioequivalence limit. MNPs are more effective in improving serum zinc status compared to CSB. Trials with larger sample sizes are recommended to validate the current findings.
Trial registration: Pan African Clinical Trials Registry: PACTR201907492232376.
Editing and Curating Online
Authors: McGann Jerome 
Published: September 2022

The complexity of natural language works, especially transinformational works, cannot be adequately represented by what has become the institutional standard for DH editorial projects, TEI. In that respect book technologies remain far superior to current digital tools in sustaining their reciprocal communicative action. Recent developments in graph database platforms suggest ways to accommodate the n-dimensionality of such work to the disambiguating inertia of digital tools.
The End of Open Society Realism?
Authors: Schuett Robert 
Published: September 2022

AbstractDoes the ‘Zeitenwende’ herald the beginning of a new and as yet undefined open society realism? The present essay argues this question requires critical discussion of nature and value of realist political theory, particularly at a time where international society is accelerating to somewhere which is itself as yet unclear. Adding to revisionist research on political realism in International Relations (IR) theory I sketch how a political vision I call open society realism may be developed out of Classical realism, in sharp distinction to academic IR neorealism for methodological and political reasons. To strip foreign policy realism from Continental philosophy, law, and history risks that we become what political liberalism ought to avoid: a closed society with a good conscience retreating from world politics, hiding behind the ‘national’ interest as if strategic great power management is a methodic function of structure rather than the politics of an ethically conscious diplomacy.
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway
Authors: Guo Jingyun , Yuan Qi , Fang Yuan , Liao Jinmao , Zhang Zheng 
Published: September 2022

Abstract
The study’s purpose was to investigate the biological function of long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in hepatoma carcinoma (HCC). HCC tissues and cells exhibited increased levels of NEAT1 and decreased levels of miR-125a-5p. Reduction in the expression of NEAT suppressed HepG2 cell proliferation and increased apoptosis. This was accompanied by suppression of the AKT/mTOR and ERK pathways, while the opposite was observed for miR-125a-5p. Angiogenesis assay results indicated that NEAT was proangiogenic. A dual-luciferase reporter assay indicated that NEAT1 was bound to miR-125a-5p and miR-125a-5p was bound to vascular endothelial growth factor (VEGF). The proangiogenic effects of NEAT and its stimulation of AKT/mTOR and ERK were reversed by miR-125a-5p. The anti-angiogenic effects of miR-125a-5p and its inhibitory effect on AKT/mTOR and ERK pathways were reversed by co-incubation with VEGF. The conclusion was that NEAT1 enhances angiogenesis in HCC by VEGF via a competing endogenous RNA (ceRNA) of miR-125a-5p that regulates AKT/mTOR and ERK pathways.