bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECTIVENESS OF USING WHATSAPP GROUP TO IMPROVE GRAMMAR ABILITY IN REPORT TEXT OF THE TENTH GRADE STUDENTS AT SMA N 1 PRAMBANAN IN THE ACADEMIC YEAR OF 2019/2020
Authors: Hidayati Ratri Nur , Machmuda Andhika Nur 
Published: March 2022

This research discusses whether there was any significant difference or not in the improvement of students’ grammar ability achievement in report text between students who were taught by using WhatsApp group and those who were not taught by using it. The population of the study were all of the tenth graders of SMA N 1 Prambanan in the academic year of 2019/2020. While, the samples were the students of X IPS 1 class as the experimental group, and the students of X IPS 2 class as the control group. Data collecting techniques used by the researcher were try out, pre-test, and post-test. Whereas, grammar test and questionnaire were used as the research instruments. In analysing the data, it was applied descriptive analysis and inferential analysis. The results showed that the mean increase in the experimental class was higher than that in the control class. Moreover, the independent sample t-test result revealed that the value of Sig. (2-tailed) was smaller than 0,05. Therefore, WhatsApp group was effective to be used as a media to teach grammar in report text at the tenth grade students of SMA N 1 Prambanan in the academic year of 2019/2020. Keywords: WhatsApp Group, Grammar, Report Text
The Role of Some Inflammatory Markers (IL-6 and CRP) in the Pathogenesis of Acute Coronary Syndrome in Iraqi CCU for Heart Diseases
Authors: GH. AbdulKarim Nadia , A. Taher Mohamed , N. Almarayati Amal 
Published: March 2022

In this work an enzyme linked immunosorbent assay (ELISA) technique has been used for detection of some inflammatory markers in serum of acute coronary syndrome (ACS)-Patients Admitted to the cardiac care unit (CCU) of Iraqi Centre For Heart Diseases and Ibn AlNafees Teaching Hospital. The present method includes quantitative measurement of interleukine-6 (IL-6) and C-reactive protein (CRP), as their increase during symptoms may be responsible for identifying the mechanism of myocardial damag, in addition to their best performance than other quantitative tests perhaps due to their association with atherosclerotic process that belongs to the endothelial dysfunction. Aim of this study is to estimate the prevalence and correlation of IL-6 with CRP in ACS- patients presented with unstable angina/ non-ST elevation myocardial infarction (UA/NSTEMI) symptoms to be as new diagnostic parameters in Iraqi CCU. Seventy (70) ACS- patients with mean age (58.55 year Â± 9.98), from Jun.2009 to Feb. 2010 with diagnosis of UA/NSTEMI were included in this study. Proper history, physical examination, electrocardiograph (ECG), and Echocardiography (ECHO) were performed for all patients in addition to the routine laboratory works including fasting blood glucose, lipid profile, assay of transaminases activity (Aspartate and Alanine transaminase),and biomarkers analysis as cardiac troponin I and T, creatine kinase (CK and CK-MB) and myoglobin. Blood sample was collected from all patients for quantitative assay of IL-6 and CRP. All patients underwent diagnostic coronary angiography, were 66 of them with abnormal coronary outcome and four patients have normal coronary arteries, study include 39- male and 31 female. Seventeen of 67 patients (25.4%) had elevated serum level of IL-6 and fifty four of 62 patients (87.1%) had elevated serum level of CRP. Statistically found strong and significant (SS) correlation between IL-6 and CRP (assessed by Spearman's rho correlation coefficient, P<0.01). The significant proportion of UA/NSTEMI patients that had elevated serum levels of IL-6 and/or CRP, in addition to the strong correlation with coronary angiographic findings make these inflammatory markers to be considered as risk stratification factors and good predictors for coronary artery disease independent of other traditional risk factors for cardiovascular disease (CVD).
Key words: ACS. IL-6. CRP.
To Study of Serum Lactate Dehydrogenase in Chronic Obstructive Pulmonary Disease Patients.
Authors: Sharma Brij Lal 
Published: March 2022

Background: To Study of serum lactate dehydrogenase in Chronic Obstructive Pulmonary Disease Patients
Methods: It is a prospective study of 100 subjects divided into two groups including 50 healthy controls and 50 cases of COPD.
Results: The statistically significant increased value of serum lactate dehydrogenase in cases as compared to control group.
Conclusion: LDH level was significantly higher in COPD patients as compare to healthy control.
Keywords: COPD, Lactate dehydrogenase, Pulmonary.
Actividad radiactiva de un electrodo de tungsteno toriado
Authors: Restrepo Giraldo Alejandro , Ramírez Quintero Juan Sebastián 
Published: March 2022

Se analiza una muestra de torio contenida en un electrodo de soldadura, mediante el uso de un contador Geiger-Müller modelo GMC-600, una cámara de niebla y un centelleador Canberra de NaI. Se caracterizan el contador Geiger y la muestra a partir de las especificaciones del fabricante y las bases de datos de estructura nuclear. Se propone un montaje para la determinación del rango en aire y el número total de decaimientos de la fuente radiactiva, y se enfatiza en la influencia de radiación de fondo y la geometría del montaje. Una vez se realiza este montaje, se reportan medidas y se interpretan desde la teoría y fuentes bibliográficas. Por último, se tienen en cuenta aspectos del riesgo de la manipulación de este objeto.
Método pilates na qualidade de vida, sobrecarga emocional e estresse de cuidadores de crianças autistas
Authors: Matos Cléssia Aparecida Alves de , Sobral Andreza Gomes , Silva Francisca Taysa de Abreu , Calaça Maria de Fátima de Carvalho , Santos Kyvia Naysis de Araujo , Riotinto Margarete Lopes , Silva Lucília da Costa , Oliveira Luciane Marta Neiva de 
Published: March 2022

Objetivos: Avaliar o efeito do Método Pilates na qualidade de vida, sobrecarga emocional e estresse dos cuidadores de crianças com Transtorno do Espectro Autista. Métodos: A presente pesquisa é um ensaio clínico controlado randomizado e foi usado para avaliação da qualidade de vida, o formulário curto de pesquisa de saúde (SF-36), para o estresse a escala de estresse percebido e para sobrecarga emocional o questionário de avaliação do impacto físico, emocional e social do papel de cuidador informal. Resultados: Foi possível notar a relação das variáveis pesquisadas com o nível de estresse, qualidade de vida e sobrecarga emocional e o efeito do Pilates sobre as mesmas. Conclusão: Concluiu-se que o Método Pilates, mostrou ser uma modalidade de exercícios físicos, com efetividade na melhora da sobrecarga emocional, nos níveis de estresse e qualidade de vida em cuidadores de crianças autistas.
PENGARUH KECERDASAN EMOSIONAL DAN LITERASI NUMERASI TERHADAP KOMPETENSI PEDAGOGIK GURU MATEMATIKA SEKOLAH MENENGAH PERTAMA (SMP) NEGERI KOTA PEKANBARU
Authors: Sari Shinta Purnama , Natuna Daeng Ayub , Afrianto Afrianto 
Published: March 2022

Penelitian ini bertujuan untuk menguji dan menganalisis 1) pengaruh kecerdasan emosional terhadap kompetensi pedagogik guru Matematika SMP Negeri kota Pekanbaru, 2) pengaruh literasi numerasi terhadap kompetensi pedagogik guru Matematika SMP Negeri kota Pekanbaru, 3) pengaruh antara kecerdasan emosional dan literasi numerasi secara bersama-sama terhadap kompetensi pedagogik guru Matematika SMP Negeri kota Pekanbaru. Populasi dari penelitian ini adalah Guru Matematika SMP Negeri Kota Pekanbaru yang berjumlah 181 orang dan sampel penelitian berjumlah 125 orang. Teknik pengumpulan data adalah angket untuk variabel kecerdasan emosional dan literasi numerasi dan untuk kompetensi pedagogik berdasarkan nilai PKG. Teknik analisis data yang digunakan adalah analisis statistik deskriptif dan analisis statistik inferensial. Pengolahan data untuk analisis statistik deskriptif dalam penelitian ini menggunakan program Microsoft Excel dan SPSS versi 25 for Windows. Hasil penelitian ini menunjukkan bahwa adanya pengaruh positif dan signifikan antara variabel kecerdasan emosional (X1) dan literasi numerasi (X2) terhadap kompetensi pedagogik guru Matematika (Y) di SMP Negeri kota Pekanbaru dan besar pengaruhnya 29.30% dengan tafsiran rendah, karena masih terdapat sebesar 70.70% ditentukan oleh faktor lain. Pengaruh ini digambarkan oleh setiap kenaikan satu satuan pada kecerdasan emosional (X1) diikuti dengan peningkatan kompetensi pedagogik guru Matematika (Y) sebesar 0.418 satu satuan dengan asumsi bahwa variabel literasi numerasi (X2) tetap dan setiap kenaikan satu satuan pada literasi numerasi (X2) diikuti dengan peningkatan kompetensi pedagogik (Y) sebesar 0,451 satu satuan dengan asumsi bahwa variabel kecerdasan emosional (X1) tetap. Temuan ini bermakna bahwa semakin baik kecerdasan emosional dan literasi numerasi guru Matematika, maka akan semakin baiklah kompetensi pedagogiknya.
PENGARUH BIMBINGAN BELAJAR TERHADAP HASIL BELAJAR IPA SISWA SMP NEGERI 1 ENDE SELATAN KECAMATAN ENDE SELATAN KABUPATEN ENDE
Authors: Jariyah Ainun , Mbia Wae Veronika Praja Sinta , Ngapa Yulius Dala 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui tingkat bimbingan belajar siswa di SMP Negeri 1 Ende Selatan, hasil belajar IPA siswa di SMP Negeri 1 Ende Selatan, dan pengaruh bimbingan belajar terhadap hasil belajar IPA siswa di SMP Negeri 1 Ende Selatan. Penelitian ini merupakan penelitian kuantitatif. Populasi dalam penelitian ini adalah siswa SMP Negeri 1 Ende Selatan dan sampel penelitian adalah siswa kelas VII, VIII, dan IX berjumlah 68 orang yang diperoleh dengan teknik purposive sampling. Data yang diperoleh dari sampel penelitian berupa skor bimbingan belajar dan nilai belajar IPA semester I tahun ajaran 2020/2021. Analisis data dilakukan dengan korelasi product moment. Hasil penelitian menunjukan bahwa bimbingan belajar memiliki pengaruh yang positif dan signifikan dengan hasil belajar IPA pada siswa kelas VII, VII, dan IX di SMP Negeri 1 Ende Selatan tahun ajaran 2020/2021, yaitu diperoleh nilai rxy= 0.509 dan thitung= 5.589>ttabel=1.667 pada α = 5%.
Analisis Variasi Bahasa pada Pelayanan Rumah Sakit Umum Daerah Kotabaru
Authors: Mubarak Husni 
Published: March 2022

The purpose of this study was (1) to describe the variations in language contained in the service at the Kotabaru Regency General Hospital, (2) to describe the factors of language variation found in the service of the Kotabaru Regency Regional General Hospital. The method used in this study is a qualitative method that is descriptive by describing objectively and the actual speech that occurs. While this type of research is a qualitative descriptive study with analyzing data through field observations with the steps of collecting, analyzing and presenting data with observation techniques, recording techniques and note taking techniques. Based on the results of research conducted, it was found that variations in the language used by doctors, nurses, and patients were three language variations namely 1. language variation in terms of facilities, namely variations or variations in spoken language; 2. variations in language based on usage terms, namely variations in language functions or registers, and 3. variations in language based on the degree of officiality are variations in business languages â€‹â€‹or variations in business, variations in casual languages â€‹â€‹(casual). And the factors of language variation in the services of the Kotabaru District General Hospital are situational factors, gender factors, occupational or professional factors, environmental factors and educational factors.

Keywords: Language Variation, Regional General Hospital Services
MELACAK AKAR SEJARAH SISTEM DAN LEMBAGAAN PENDIDIKAN ISLAM PADA MASA RASULULLAH SAW (PERIODE MEKKAH DAN MADINAH
Authors: DP Usman 
Published: March 2022

In a historical perspective, Islamic education as a sub system of the education system in general way only known after the sending of the Prophet Muhammad SAW has a messenger of Allah SWT. The retise unders prophet Muhammad SAW covers the system that axixts in the life on the universe, Islamic education refers to Islamic values. Therefore, the Islamic education system has a fundamental difference with the education system built by education both in the East and West . During the leadership of the prophet Muhammad SAW, Islamic education was built on a monolothic basis, which was sourced from revelation, namely the Qur’an and Hadith. Therefore, Islamic education is not known has a dichotomous term, the separation between religious education and general education.

Keywords: Islamic Education System and Institution, Rasulullah SAW.
Evaluation of Euglena gracilis 815 as a New Candidate for Biodiesel Production
Authors: Chen Zixi , Chen Yehua , Zhang Hua , Qin Huan , He Jiayi , Zheng Zezhou , Zhao Liqing , Lei Anping , Wang Jiangxin 
Published: March 2022

Euglena comprises over 200 species, of which Euglena gracilis is a model organism with a relatively high fatty acid content, making it an excellent potential source of biodiesel. This study isolated and characterized a new strain named E. gracilis 815. E. gracilis 815 cells were cultivated under light and dark conditions, with either ethanol or glucose as an external carbon source and an autotrophic medium as control. To achieve maximum active substances within a short period i.e., 6 days, the effects of the light condition and carbon source on the accumulation of bioactive ingredients of E. gracilis 815 were explored, especially fatty acids. In comparison with the industrially used E. gracilis Z strain, E. gracilis 815 exhibited high adaptability to different carbon sources and light conditions, with a comparable biomass and lipid yield. The content and composition of fatty acids of E. gracilis 815 were further determined to assess its potential for biodiesel use. Results suggested that E. gracilis 815 has biodiesel potential under glucose addition in dark culture conditions and could be a promising source for producing unsaturated fatty acids. Therefore, E. gracilis 815 is a candidate for short-chain jet fuel, with prospects for a wide variety of applications.
Electrochemical Detection of Alzheimer’s Disease Biomarker, β-Secretase Enzyme (BACE1), With One-Step Synthesized Reduced Graphene Oxide
Authors: Dey Jhilik , Roberts Akanksha , Mahari Subhasis , Gandhi Sonu , Tripathi Prem Prakash 
Published: March 2022

β-Secretase1 (BACE1) catalyzes the rate-limiting step in the generation of amyloid-β peptides, that is, the principal component involved in the pathology of Alzheimer’s disease (AD). Recent research studies show correlation between blood and cerebrospinal fluid (CSF) levels of BACE1 with the pathophysiology of AD. In this study, we report one-step synthesized reduced graphene oxide (rGO), activated via carbodiimide chemistry, conjugated with BACE1 antibody (Ab), and immobilized on fluorine-doped tin oxide (FTO) electrodes for rapid detection of BACE1 antigen (Ag) for AD diagnosis. The synthesis and fabrication steps were characterized using different types of spectroscopic, X-ray analytic, microscopic, and voltametric techniques. Various parameters including nanomaterial/Ab concentration, response time, pH, temperature, and rate of scan were standardized for maximum current output using the modified electrode. Final validation was performed via detection of BACE1 Ag ranging from 1 fM to 1 µM, with a detection limit of 0.64 fM in buffer samples and 1 fM in spiked serum samples, as well as negligible cross-reactivity with neurofilament Ag in buffer, spiked serum, and spiked artificial CSF. The proposed immunosensor gave a quick result in 30 s, and good repeatability and storage stability for a month, making it a promising candidate for sensitive, specific, and early diagnosis of AD. Thus, the fabricated electrochemical biosensor for BACE-1 detection improves detection performance compared to existing sensors as well as reduces detection time and cost, signifying its potential in early diagnosis of AD in clinical samples.
SLC1A5 Prefers to Play as an Accomplice Rather Than an Opponent in Pancreatic Adenocarcinoma
Authors: Xu Fangshi , Wang Hai , Pei Honghong , Zhang Zhengliang , Liu Liangliang , Tang Long , Wang Shuang , Ren Bin-Cheng 
Published: March 2022

Background: SLC1A5, a ferroptosis regulator gene, plays a dual role in cancer regulation. However, the roles of SLC1A5 in pancreatic adenocarcinoma (PAAD) remain elusive.Methods: SLC1A5’s expression and somatic mutation information were determined by TCGA, GEO, Oncomine, and cBioPortal databases. Its prognostic value was assessed in TCGA cohort and was validated in three independent cohorts. The effects of SLC1A5 on the tumor immune microenvironment were analyzed by the CIBERSORT algorithm, ssGSEA method, and TISIDB and TIMER databases. The “oncoPredict” R package, TIDE algorithm, ImmuCellAI online tool, and GSE35141 and GSE59357 datasets were used to ascertain its therapeutic correlations. GSEA and Western blot were applied to reveal the effects of SLC1A5 on the mTORC1 signaling pathway and ferroptosis process. The biofunctions of SLC1A5 were assessed by MTT, wound-healing, Transwell, and xenograft assays.Results: SLC1A5 was significantly upregulated in the PAAD samples but was not commonly accompanied with somatic mutation (2.3%). Overexpression of SLC1A5 led to a poor prognosis and was identified as an independent prognostic factor. Moreover, high SLC1A5 expression suppressed the antitumor immune process by changing the infiltrating levels of immune cells. As for therapeutic correlations, SLC1A5 was related to the efficacy of dasatinib, sunitinib, sorafenib, and imatinib but may not predict that of radiotherapy, chemotherapeutic drugs, and immune checkpoints inhibitors (ICIs). Notably, the overexpression of SLC1A5 could activate the mTORC1 signaling pathway and may increase the cellular sensitivity to ferroptosis. Finally, the overexpression of SLC1A5 markedly promoted proliferation, migration, and invasion of pancreatic cancer cells. At the in vivo level, SLC1A5 deletion inhibited tumor growth in a mice xenograft model.Conclusions: SLC1A5 prefers to play as an accomplice rather than an opponent in PAAD. Our findings provide novel insights into PAAD treatment.
Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway
Authors: Wang Yanjun , Liu Lin , Qu Zechao , Wang Dong , Huang Wangli , Kong Lingbo , Yan Liang 
Published: March 2022

Purpose: Osteoporosis, a common disorder especially prevalent in the postmenopausal women and the elderly, is becoming a worldwide public health problem. Osteoporosis can cause severe joint pain, fragility fractures, and other symptoms, which can seriously impair the daily lives of affected patients. Currently, no gold-standard drug is available that can completely cure osteoporosis. Tanshinone is a traditional Chinese medicine, which can exhibit multiple biological activities. It might also display a protective effect on osteoporosis. However, the molecular mechanism through which tanshinone can improve osteoporosis remain unclear. The objective of our study is to explore the underlying mechanism behind the protective actions of tanshinone.Methods: The common KEGG pathways of tanshinone-targeted genes and osteoporosis were analyzed by using bioinformatics analysis. The bioinformatics analysis results were further validated both by in vitro and in vivo experiments.Results: 21 common KEGG pathways were identified between osteoporosis and tanshinone-targeted genes. It was further found that tanshinone could induce expression of AKT1, promote the proliferation of MSCs, and ultimately suppress their apoptosis.Conclusion: Taken together, our findings indicate that tanshinone can alleviate osteoporosis, its effect was potentially mediated through modulating AKT1 expression. Thus, tanshinone could serve as a promising treatment option for osteoporosis.
Developing a Sustainable Cardiovascular Disease Research Strategy in Tanzania Through Training: Leveraging From the East African Centre of Excellence in Cardiovascular Sciences Project
Authors: Chillo Pilly , Mashili Fredirick , Kwesigabo Gideon , Ruggajo Paschal , Kamuhabwa Appolinary 
Published: March 2022

IntroductionCardiovascular disease (CVD) contribute the largest mortality burden globally, with most of the deaths (80% of all deaths) occurring in low and middle-income countries (LMICs), including Tanzania. Despite the increasing burden, to date, CVD research output is still limited in Tanzania, as it is for many sub-Saharan Africa (SSA) countries. This trend hinders the establishment of locally informed CVD management and policy changes. Here, we aim to review the existing gaps while highlighting the available opportunities for a sustainable CVD research strategy in Tanzania.MethodsA rapid review of available literature on CVD research in SSA was conducted, with emphasis on the contribution of Tanzania in the world literature of CVD. Through available literature, we identify strategic CVD research priorities in Tanzania and highlight challenges and opportunities for sustainable CVD research output.FindingsShortage of skilled researchers, inadequate research infrastructure, limited funding, and lack of organized research strategies at different levels (regional, country, and institutional) are among the existing key bottlenecks contributing to the low output of CVD research in Tanzania. There is generally strong global, regional and local political will to address the CVD epidemic. The establishment of the East African Centre of Excellence in Cardiovascular Sciences (EACoECVS) offers a unique opportunity for setting strategies and coordinating CVD research and training for Tanzania and the East African region.ConclusionThere is a light of hope for long-term sustainable CVD research output from Tanzania, taking advantage of the ongoing activities and plans for the evolving EACoECVS. The Tanzanian experience can be taken as a lesson for other SSA countries.