bluuebunny/crossref_metadata_2025_split huggingface dataset:
438 INCIDENT HYPOCHLOREMIA AMONG PATIENTS WITH TAKOTSUBO SYNDROME: SHORT- AND LONG-TERM OUTCOME. RESULTS FROM A MULTICENTER PROSPECTIVE REGISTRY.
Authors: Cetera Rosa , Santoro Francesco , Vitale Enrica , Ragnatela Ilaria , Mallardi Adriana , Leopizzi Alessandra , Matera Annalisa , Correale Michele , Iacoviello Massimo , Brunetti Natale Daniele 
Published: December 2022

Abstract

Background
Takotsubo syndrome (TTS) is an acute heart failure syndrome featured by a reversible left ventricular systolic dysfunction with significant rate of in- and out-of-hospital mayor cardiac adverse events (MACE).

Aim of the study
To evaluate the possible role of hypochloremia as prognostic marker at short- and long-term follow-up in subjects with TTS.

Methods
305 consecutive patients were enrolled in a multicenter international registry. Clinical, laboratory and echocardiographic evaluations were performed at admission and during hospitalization. Incident hypochloremia (serum chloride level below 97 mEq/l) during hospitalization was recorded. In-hospital MACE, short- and long-term mortality was recorded.

Results
Mean admission serum chloride levels were 102±5 mEq/l. 97 out of 305 (37%) patients experienced incident hypochloremia. Patients with incident hypochloremia were older (78±10 vs 73±12 years, p=0.01), had lower admission LVEF (34±8% vs 37±8%, p=0.009), and longer hospital stay (9±4 vs 7±4 days, p=0.0003).
During hospitalization patients with incident hypochloremia had higher rates of complication (45% vs 32%, p=0.01), lower levels of natremia and azotemia at admission and discharge.
At long term follow-up incident hypochloremia was associated with increased risk of MACE (49% vs 32%, p=0.005) and death (42% vs 24%, p=0.002, log rank p&lt;0.01).

Conclusion
Incident hypochloremia is a common finding among hospitalized patients with TTS, associated with higher risk of in-hospital events and long-term MACE and death.
864 ISOLATED CARDIAC METASTASIS FROM CARCINOMA OF THE CERVIX: RARE CASE OF ACS-NSTE. CASE REPORT
Authors: Ventura Ettore , Scalzi Giuseppe , Riverso Vincenzo , Serraino Filiberto , Petulla´ Maria , Mascaro Giuseppina , Indolfi Ciro , Aquila Iolanda 
Published: December 2022

Abstract

Introduction
The heart is a rare site of tumor metastasis. Although rarely, cardiac metastases may be secondary to a primary intra-abdominal tumor.

Aim
we report the case of a 60-years-old woman, ante-mortem finding of an isolated cardiac metastasis from cervical carcinoma presented as ACS-NSTE, who was evaluated in our Division of Cardiology.

Materials and methods
electrocardiogram, transthoracic echocardiography, angioTC, cardiac surgery and histopathologic analysis were performed.

Results
electrocardiogram showed incomplete right branch block with diffuse negative T waves. On the echocardiogram evidence of a voluminous hypo-isoechoic formation almost completely occupying the cavity of the right ventricule (RV) which appeared dilated and dysfunctional; D-shape aspect of the left ventricule as from the overload of the right sections and with moderate pericardial effusion, mildly reduced ejection fraction (EF50%Q). An urgent Angio-CT was performed and revealed a voluminous solid neoformation with inhomogeneous content and progressive contrast enhancement in the right ventricule. Following admission, the patient's haemodynamic status gradually worsened. Therefore, urgent cardiac surgery was performed. After drainage of abundant serum/haematic effusion, probably neoplastic infiltration of RV was seen. Therefore, given the extension it was decided to perform only multiple biopsies. Histopathological examination revealed moderately differentiated squamous cell carcinoma, as from metastasis from K. cervix.

Conclusions
there is no standardized therapy for the treatment of cardiac metastases, it is necessary to evaluate on a case-by-case basis. The most important prognostic factors are the obstructive effect of the intracardiac mass and the extent of any pericardial effusion. In fact, they can adversely affect hemodynamic stability.
425 THE IMPACT OF NURSING EDUCATION ON THE QUALITY OF LIFE IN PATIENTS WITH HEART FAILURE DURING CARDIAC REHABILITATION: A SYSTEMATIC REVIEW
Authors: Li Vigni Myriam Letizia , Artiola Gaetano , Cappelli Sara , Meucci Beatrice , Lulli Maria Sole 
Published: December 2022

Abstract

Introduction
Heart failure (HF) occurs in 26 million people worldwide and is one of the most common causes of hospitalization, hospital readmission and death. To overcome this, ESC guidelines recommend the cardiologic rehabilitation pathway, which places the patient with HF at the center of his or her care pathway with the aim of improving quality of life through the implementation of a personalized multidisciplinary program. In the cardiology rehabilitation pathway, the nurse plays a key role of education and support, encouraging the patient to change. The aim of the review is to explore the quality of life of the elderly patient with HF and the educational role of nursing in the cardiac rehabilitation setting.

Materials and Methods
A systematic search was conducted using PUBMED, CINAHL until June 2022, according to REA methodology.
The quality of the study was assessed by three reviewers using the DIXONWOOD checklist.

Results
and discussion: Analysis of the results suggests that multiple aspects need to be considered to improve the management and quality of life of patients with HF. Among these, the literature cites the implementation of a network of nurse case managers, standardization of operative protocols, mental and physical pain management, and cardiac rehabilitation units after hospital discharge. It also shows how physical activity, according to the ERIC-HF program, can improve the ability to perform ADL activities (Kang Y. et all, 2020). An additional study found that home cardiac rehabilitation intervention results in clinically significant improvement in disease-related quality of life in patients with HF.
Cost-utility analyses support that home cardiac rehabilitation programs are cost-effective treatments for patients with HF and that nurses play a key role in educating and managing their condition (Rod s. et all, 2019). They should encourage patients with heart failure to practice cardiac rehabilitation for a longer period to improve their quality of life. One study shows that rehabilitation intervention for caregivers of patients with HF is helpful in supporting their role and improving their confidence (Wingham J. et all, 2019).

Conclusions
Cardiac rehabilitation in which nurses are present proves to be crucial in both psychological (Suzanne H et al, 2018) and exercise-enhancing projects to improve long-term health conditions, as shown by Kentaro, K., this approach produces benefits on patients with HF and their caregivers. It induces in the patient greater autonomy in daily activities, medication adherence and self-care of the disease, delaying its progression. At the same time, for caregivers there is a reduction in caregiver burden resulting in economic, emotional and social improvement. For the National Health Service, there is a reduction in length of stay in intensive care and emergency departments and consequently, a decrease in costs.
10 RADIOLOGICAL ANATOMY OF THE HEART AND MEDIASTINUM IN ELECTROSTIMULATION: A GUIDE FOR TSRM, NURSES AND TFCPC
Authors: Santucci Stefano , Santucci Matteo 
Published: December 2022

Abstract
For the implantation of the PM, iodized contrast medium is rarely used and to recognize the anatomical structures within which one is operating, one must resort to the interpretation of only the radiological images obtained with the use of ionizing radiation. To verify the correct positioning of the leads, it is necessary to have multiple points of view (projections). Confirmation is usually sought with at least two projections that are almost orthogonal to each other. The fluoroscopic visualization shows a two-dimensional antomy typical of radiological imaging and we speak of a cardiac shadow formed by the overlapping of all vascular structures
Typical views to visualize correct lead placement require multiple views, usually two. The projections RAO 20-25 ° and LAO 25-30 ° are almost orthogonal. With the first, the cardiac silhouette shows the right ventricle in its maximum longitudinal extension. With the LAO, the left ventricle and the right ventricle are represented paired with a view comparable to the 4-chamber ultrasound imaging
Knowledge of radiological anatomy is very important in determining the correct positioning of the leads.
12 NUERSING MANAGEMENT RADIAL ACCESS WITH COMPRESSION BADAGE APPLICATION
Authors: Franchetti Domenico , Negossi Davide , Santucci Stefano 
Published: December 2022

Abstract
Radial access is now a diagnostic approach increasingly used in hemodynamics rooms, from the election procedure to primary emergency angioplasty Such access certainly guarantees minor bleeding complications, above all but ensures the patient a better comfort and well-being.
Nursing management of post-procedure radial vascular access is extremely important and early The radial approach according to Seldinger, requires, at the end of the procedure, except in special cases, the removal of the vascular valve introducer, usually of 5 or 6 French caliber, and to carry it out, the compression dressing must be taut.
This dressing can be done with mechanical compression means, see the air cushion bracelet, both with the classic and traditional elastic compression bandage.
The work will show how, in our laboratory, using the traditional dressing consistently, we used two types of dressing.
The classic one made with tensoplast, and the other using self-adhesive gauze bandages.
In both the packaging is custom, with the difference that the first is performed by two nurses while the second is performed only by one nurse
689 IMPACT OF RENIN-ANGIOTENSIN SYSTEM INHIBITORS ON CLINICAL OUTCOME IN HYPERTENSIVE PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION: INSIGHT FROM THE EFFECTAVI REGISTRY
Authors: Basile Christian , Mancusi Costantino , Franzone Anna , Avvedimento Marisa , Angellotti Domenico , Castiello Domenico Simone , Mariani Andrea , Manzo Rachele , Cirillo Plinio , De Simone Giovanni , Esposito Giovanni 
Published: December 2022

Abstract

Aims
Left ventricular pressure overload is connected with cardiac renin–angiotensin system activation, which may lead to myocardial fibrosis and poorer clinical outcomes. Hypertensive patients with symptomatic, severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) in the EffecTAVI registry were evaluated for the association between baseline treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and clinical outcomes.

Methods and results
The research comprised 373 patients with moderate, high, or prohibitive risk who had TAVI in the EffecTAVI registry (NCT05235555). Using Kaplan–Meier event rates and study-stratified multivariable Cox proportional hazards regression models, we evaluated clinical outcomes at 2 years according to ACEi/ARB therapy status at baseline. Among the 327 patients with hypertension included in the present study, 222 (67.9%) were treated with ACEI/ARB at baseline, whereas 105 (32.1%) were not. Treatment with ACEI/ARB was related with decreased all-cause mortality (HR=0.46, 95% CI 0.25-0.90, p=0.011), although this association was not statistically significant after multivariable adjustment for important covariates. Analyzing pre-procedural ACEi and ARBs separately, ARBs administration was related with a 58% decrease in all-cause mortality (HR=0.42, 95% CI 0.18-0.98, p=0.04), which was confirmed in multivariate analysis.

Conclusion
In a small cohort of hypertensive patients with severe symptomatic AS from the EffecTAVI registry, ARBs treatment at baseline was independently associated with a lower risk of 2-year all-cause mortality.
224 RIGHT VENTRICULAR MECHANICS AND THE CLINICAL IMPLICATION OF 2D SPECKLE TRACKING ASSESSMENT IN SEVERE AORTIC STENOSIS
Authors: Springhetti Paolo , Ciceri Luca , Urbani Giulia , Dotto Alberto , Maffeis Caterina , Tafciu Elvin , Bergamini Corinna , Rossi Andrea , Ribichini Flavio , Benfari Giovanni 
Published: December 2022

Abstract

Introduction
The prognostic role of RV function assessment in severe AS has been demonstrated in previous studies. However, the role of 2D speckle tracking RV evaluation in the context of severe AS has not been completely clarified.

Methods
We retrospectively evaluated consecutive patients with severe AS referred to TAVI at our institution. Exclusion criteria were severe aortic regurgitation, severe mitral stenosis and poor acoustic window for a correct 2D speckle tracking right chamber evaluation.
The echocardiographic exams were analyzed off-line with a semi-automatic software (Tomtec Arena, Autostrain ®) to assess RVFW strain and LV GLS. Additionally, a conventional echocardiographic evaluation was made in both right and left chambers (LVEF, FAC, LVEF).
Prevalence of conventional RV disfunction was defined as a TAPSE&lt;17 mm or FAC&lt;35%. RVFW impairment cuf-off was defined below 20%.
Multivariate regression models were elaborate to assess the major determinants of RV function.
Moreover, logistic regression analysis has been made to analyze if RV function could predict high-risk clinical features in the context of severe AS.

Results
Our cohort was composed of 110 consecutive patients. Mean RVFW was 21±7%, TAPSE 21±4 mm, FAC 44±11% and mean RV area 10±4 cmq/mq. The prevalence of RV disfunction defined by standard echocardiography was 26% (29 patients), instead, RVFW was impaired (below 20%) in 53 patients (40%). At multivariate regression analysis, the main RVFW determinants were MR, AS severity, LVMI, GLS and E/e’ (R2 0.68, p&lt;0.001 including AVA; R2 0.53, p&lt;0.001 including mean gradient).
At logistic regression analysis RVFW strain was associated with previous HF hospitalization admission independently from TAPSE (CI 95% 1.03–1.22, p=0.008). Furthermore in a second model, RVFW strain was a significant predictor of advanced NYHA class independently from FAC (CI 95%, 1.01–1.18, p=0.0036).

Conclusion
The major determinants of RV function in patients with severe AS were MR and LV function. A pressure overload driven by the MR-LV dysfunction combination on right sided heart could impact profoundly negatively on RV function. RVFW strain in this study resulted a more sensitive parameter that conventional RV assessment in highlighting more symptomatic severe-AS patients.
564 AN UNUSUAL PRESENTATION OF ICA DISSECTION. A CASE OF TRANSIENT GLOBAL AMNESIA IN A PATIENT WITH PAINLESS SPONTANEOUS INTERNAL CAROTID ARTERY DISSECTION
Authors: Natale Francesco , Loffredo Francesco , Molinari Riccardo , Covino Simona , Alfieri Roberta , Altobelli Ippolita , Cimmino Giovanni 
Published: December 2022

Abstract

Image focus
A 42-year-old woman was carried to emergency room lamenting sudden memory loss. Her husband witnessed the onset of the episode. No recent head trauma was reported, blood pressure was under control.
Anterograde and retrograde memory loss was present and confirmed by a neurologist. No other neurological signs were elicitable. Blood exams and toxicological analysis were negative. ECG, chest radiography, and cerebral TC showed no abnormalities. At physical examination a carotid bruit could be appreciated.
We performed an eco-color-Doppler of carotid artery that showed a left common and internal carotid artery dissection (figure 1). The diagnosis of ICA dissection was confirmed with a contrast CT. The coexistence of an aortic dissection was excluded with the same imaging technique.
The anterograde amnesia resolved 15 h after the admission. A neurologist confirmed that the patient experimented an episode of transient global amnesia (TGA).
After a vascular surgery consultation, a conservative treatment was deemed appropriate. After a 6 month follow up the patient didn't complain of any other neurological symptom or sign.
Transient global amnesia (TGA) is characterized by reversible anterograde and retrograde amnesia of sudden onset. This amnesic syndrome resolves spontaneously within 24 h. Annual incidence rate for all ages of spontaneous ICA dissection is approximately of 2.6 per 100 000 inhabitants, however data are extremely variable among different studies. TGA has never been associated with a spontaneous ICA dissection. In order to not miss a spontaneous ICA dissection as a rare ethology of TGA, we suggest performing an eco-color-Doppler of the epi-aortic vessels in patient affected by such amnesic syndrome.
Fact-checking as a deterrent? A conceptual replication of the influence of fact-checking on the sharing of misinformation by political elites
Authors: Ma Siyuan , Bergan Daniel , Ahn Suhwoo , Carnahan Dustin , Gimby Nate , McGraw Johnny , Virtue Isabel 
Published: December 2022

Abstract
In a field experiment conducted during the 2012 general elections in the U.S., Nyhan and Reifler found that the threat of fact-checking deterred state legislators from making false or misleading statements. The current study presents a conceptual replication and extension of this influential study by utilizing a similar treatment that leverages a recent partnership between local media outlets and fact-checking organizations, assessing the effects of the treatment on the accuracy of legislators’ statements on Twitter around the first impeachment trial of Donald Trump. Results provide limited evidence of the effects of our treatment on the accuracy of legislators’ posts, even among legislators within media markets directly affected by this partnership. We conclude with a discussion of the theoretical and practical relevance of these results and avenues for future research.
Deconstructing age(s): an analysis of the different conceptions of age as a legal criterion for access to assisted reproductive technologies
Authors: Martani Andrea , De Clercq Eva , De Geyter Christian , Pennings Guido , Wangmo Tenzin , Elger Bernice Simone 
Published: December 2022

Abstract
Whether there should be restrictions for access to Assisted Reproductive Technologies (ART) is a matter of continuous medical, societal, and ethico-legal debate. One of the most controversial topics in this context is the use of parental age as a criterion to limit access to ART. Views are divided on whether there should be an upper age limit for one or both parents and on where such limits should be. Although this debate is centered around the issue of ‘age’ and although age-related limits are present in many legislations, the intrinsic ambiguity of the term `age' is largely overlooked.
In this article, we build on gerontological, medical, and sociological literature on the concepts of ‘age’ and ‘aging’ to distinguish three conceptions of age that are relevant for ART regulation: the chronological, the biological, and the social-cultural one. Beyond mapping out these conceptions of age, we describe how they relate to ART and reproduction, and illustrate the advantages and disadvantages of relying on each of them as a basis for limiting ART access. Finally, we propose a template for defining legal age limits for ART access in the law, based on the refined understanding of the different conceptions of age that we outline and we discuss two potential objections to our proposal.
Intraneuronal tau aggregation induces the integrated stress response in astrocytes
Authors: Batenburg Kevin L , Kasri Nael N , Heine Vivi M , Scheper Wiep 
Published: December 2022

ABSTRACTProgressive aggregation of tau protein in neurons is associated with neurodegeneration in tauopathies. Cell non-autonomous disease mechanisms in astrocytes may be important drivers of the disease process but remain largely elusive. Here, we studied cell type-specific responses to intraneuronal tau aggregation prior to neurodegeneration. To this end, we developed a fully human co-culture model of seed-independent intraneuronal tau pathology, which shows no neuron and synapse loss. Using high-content microscopy, we show that intraneuronal tau aggregation induces oxidative stress accompanied by activation of the integrated stress response specifically in astrocytes. This requires the direct co-culture with neurons and is not related to neurodegeneration or extracellular tau levels. Tau-directed antisense therapy reduced intraneuronal tau levels and aggregation and prevented the cell non-autonomous responses in astrocytes. These data identify the astrocytic integrated stress response as a novel disease mechanism activated by intraneuronal tau aggregation. In addition, our data provide the first evidence for the efficacy of tau-directed antisense therapy to target cell autonomous and cell non-autonomous disease pathways in a fully human model of tau pathology.
Changes in Elective and Urgent Surgery Among TRICARE Beneficiaries During the COVID-19 Pandemic
Authors: Crawford Alexander M , Lightsey IV Harry M , Xiong Grace X , Ye Jamie , Call Catherine M , Pomer Alysa , Cooper Zara , Simpson Andrew K , Koehlmoos Tracey P , Weissman Joel S , Schoenfeld Andrew J 
Published: December 2022

ABSTRACT

Background
COVID-19 is known to have altered the capacity to perform surgical procedures in numerous health care settings. The impact of this change within the direct and private-sector settings of the Military Health System has not been effectively explored, particularly as it pertains to disparities in surgical access and shifting of services between sectors. We sought to characterize how the COVID-19 pandemic influenced access to care for surgical procedures within the direct and private-sector settings of the Military Health System.

Methods
We retrospectively evaluated claims for patients receiving urgent and elective surgical procedures in March–September 2017, 2019, and 2020. The pre-COVID period consisted of 2017 and 2019 and was compared to 2020. We adjusted for sociodemographic characteristics, medical comorbidities, and region of care using multivariable Poisson regression. Subanalyses considered the impact of race and sponsor rank as a proxy for socioeconomic status.

Results
During the period of the COVID-19 pandemic, there was no significant difference in the adjusted rate of urgent surgical procedures in direct (risk ratio, 1.00; 95% CI, 0.97–1.03) or private-sector (risk ratio, 0.99; 95% CI, 0.97–1.02) care. This was also true for elective surgeries in both settings. No significant disparities were identified in any of the racial subgroups or proxies for socioeconomic status we considered in direct or private-sector care.

Conclusions
We found a similar performance of elective and urgent surgeries in both the private sector and direct care during the first 6 months of the COVID-19 pandemic. Importantly, no racial disparities were identified in either care setting.