bluuebunny/crossref_metadata_2025_split huggingface dataset:
A summative content analysis of how programmes to improve the right to sexual and reproductive health address power
Authors: Schaaf Marta , Boydell Victoria , Topp Stephanie M , Iyer Aditi , Sen Gita , Askew Ian 
Published: April 2022

IntroductionPower shapes all aspects of global health. The concept of power is not only useful in understanding the current situation, but it is also regularly mobilised in programmatic efforts that seek to change power relations. This paper uses summative content analysis to describe how sexual and reproductive health (SRH) programmes in low-income and middle-income countries explicitly and implicitly aim to alter relations of power.MethodsContent analysis is a qualitative approach to analysing textual data; in our analysis, peer-reviewed articles that describe programmes aiming to alter power relations to improve SRH constituted the data. We searched three databases, ultimately including 108 articles. We extracted the articles into a spreadsheet that included basic details about the paper and the programme, including what level of the social ecological model programme activities addressed.ResultsThe programmes reviewed reflect a diversity of priorities and approaches to addressing power, though most papers were largely based in a biomedical framework. Most programmes intervened at multiple levels simultaneously; some of these were ‘structural’ programmes that explicitly aimed to shift power relations, others addressed multiple levels using a more typical programme theory that sought to change individual behaviours and proximate drivers. This prevailing focus on proximate behaviours is somewhat mismatched with the broader literature on the power-related drivers of SRH health inequities, which explores the role of embedded norms and structures.ConclusionThis paper adds value by summarising what the academic public health community has chosen to test and research in terms of power relations and SRH, and by raising questions about how this corresponds to the significant task of effecting change in power relations to improve the right to SRH.
Teams and continuity of end-of-life care in hospitals: managing differences of opinion
Authors: Devery Kim , Winsall Megan , Rawlings Deb 
Published: April 2022

BackgroundRecognised as an essential element in end-of-life care by the Australian Commission on Safety and Quality in Health Care, effective teamwork can enhance the quality and safety of end-of-life care for patients in hospitals. End-of-Life Essentials (EOLE) is a Commonwealth funded project that delivers peer-reviewed, evidence-based, online education and practice change resources for doctors, nurses and allied health professionals working in hospitals. ‘Teams and Continuity for the Patient’ features in the suite of EOLE modules and includes education around effective teamwork in end-of-life care. The aim of this study was to explore the views of module learners on managing differences of opinion among staff regarding patient care management.MethodsParticipants were learners (health professionals) who registered to the EOLE website and engaged with the Teams module. Learner responses to a question posed at the end of the module ‘How do you manage differences of opinion among staff regarding patient care management?’ were extracted for a 12-month period. Qualitative data were analysed thematically in NVivo V.12, with pragmatism as an overarching theoretical framework. Data were coded using an inductive, open approach, and axial coding was used to organise the codes into themes and subthemes.FindingsA total of 293 learner statements were analysed, with subthemes organised into three overarching themes:prioritising the patient, team collaborationandcommunication skills and emotional awareness.ConclusionIn complex, fast-paced, hospital environments, the potential for conflict among teams is high. Quality care relies on team members who work in unison, who can also recognise conflict emerging and respond in respectful and appropriate ways. In this study, the management actions reported by health professionals as proving helpful when differences of opinion among team members arise, are valuable to organisations who are considering how to prepare for quality and safety accreditation.
Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study
Authors: Tannir Nizar M , Cho Daniel C , Diab Adi , Sznol Mario , Bilen Mehmet A , Balar Arjun V , Grignani Giovanni , Puente Erika , Tang Lily , Chien David , Hoch Ute , Choudhury Arkopal , Yu Danni , Currie Sue L , Tagliaferri Mary A , Zalevsky Jonathan , Siefker-Radtke Arlene O , Hurwitz Michael E 
Published: April 2022

BackgroundImmune checkpoint inhibitor-based combinations have expanded the treatment options for patients with renal cell carcinoma (RCC); however, tolerability remains challenging. The aim of this study was to evaluate the safety and efficacy of the immunostimulatory interleukin-2 cytokine prodrug bempegaldesleukin (BEMPEG) plus nivolumab (NIVO) as first-line therapy in patients with advanced clear-cell RCC.MethodsThis was an open-label multicohort, multicenter, single-arm phase 1/2 study; here, we report results from the phase 1/2 first-line RCC cohort (N=49). Patients received BEMPEG 0.006 mg/kg plus NIVO 360 mg intravenously every 3 weeks. The primary objectives were safety and objective response rate (ORR; patients with measurable disease at baseline and at least one postbaseline tumor response assessment). Secondary objectives included overall survival (OS) and progression-free survival (PFS). Exploratory biomarker analyses: association between baseline biomarkers and ORR.ResultsAt a median follow-up of 32.7 months, the ORR was 34.7% (17/49 patients); 3/49 patients (6.1%) had a complete response. Of the 17 patients with response, 14 remained in response for >6 months, and 6 remained in response for >24 months. Median PFS was 7.7 months (95% CI 3.8 to 13.9), and median OS was not reached (95% CI 37.3 to not reached). Ninety-eight per cent (48/49) of patients experienced ≥1 treatment-related adverse event (TRAE) and 38.8% (19/49) had grade 3/4 TRAEs, most commonly syncope (8.2%; 4/49) and increased lipase (6.1%; 3/49). No association between exploratory biomarkers and ORR was observed. Limitations include the small sample size and single-arm design.ConclusionsBEMPEG plus NIVO showed preliminary antitumor activity as first-line therapy in patients with advanced clear-cell RCC and was well tolerated. These findings warrant further investigation.
Degeneration of topological string partition functions and mirror curves of the Calabi–Yau threefolds $$X_{N,M}$$
Authors: Ahmed Ambreen , Muteeb M. Nouman 
Published: April 2022

AbstractIn this article we study certain degenerations of the mirror curves associated with the Calabi–Yau threefolds $$X_{N,M}$$

X

N
,
M

, and the effect of these degenerations on the refined topological string partition function of $$X_{N,M}$$

X

N
,
M

. We show that when the mirror curve degenerates and become the union of the lower genus curves the corresponding partition function factorizes into pieces corresponding to the components of the degenerate mirror curve. Moreover we show that using degeneration of a generalised mirror curve it is possible to obtain the partition function corresponding to $$X_{N,M-1}$$

X

N
,
M
-
1

from $$X_{N,M}$$

X

N
,
M

.
SETD2 Haploinsufficiency Enhances Germinal Center–Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis
Authors: Leung Wilfred , Teater Matt , Durmaz Ceyda , Meydan Cem , Chivu Alexandra G. , Chadburn Amy , Rice Edward J. , Muley Ashlesha , Camarillo Jeannie M. , Arivalagan Jaison , Li Ziyi , Flowers Christopher R. , Kelleher Neil L. , Danko Charles G. , Imielinski Marcin , Dave Sandeep S. , Armstrong Scott A. , Mason Christopher E. , Melnick Ari M. 
Published: April 2022

Abstract

SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in splicing, transcription initiation, and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 mutation is typically heterozygous in diffuse large B-cell lymphomas. Here we show that heterozygous Setd2 deficiency results in germinal center (GC) hyperplasia and increased competitive fitness, with reduced DNA damage checkpoint activity and apoptosis, resulting in accelerated lymphomagenesis. Impaired DNA damage sensing in Setd2-haploinsufficient germinal center B (GCB) and lymphoma cells associated with increased AICDA-induced somatic hypermutation, complex structural variants, and increased translocations including those activating MYC. DNA damage was selectively increased on the nontemplate strand, and H3K36me3 loss was associated with greater RNAPII processivity and mutational burden, suggesting that SETD2-mediated H3K36me3 is required for proper sensing of cytosine deamination. Hence, Setd2 haploinsufficiency delineates a novel GCB context–specific oncogenic pathway involving defective epigenetic surveillance of AICDA-mediated effects on transcribed genes.

Significance:
Our findings define a B cell–specific oncogenic effect of SETD2 heterozygous mutation, which unleashes AICDA mutagenesis of nontemplate strand DNA in the GC reaction, resulting in lymphomas with heavy mutational burden. GC-derived lymphomas did not tolerate SETD2 homozygous deletion, pointing to a novel context-specific therapeutic vulnerability.
This article is highlighted in the In This Issue feature, p. 1599
Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF
Authors: Adamson Carly , Docherty Kieran F. , Heerspink Hiddo J.L. , de Boer Rudolf A. , Damman Kevin , Inzucchi Silvio E. , Køber Lars , Kosiborod Mikhail N. , Martinez Felipe A. , Petrie Mark C. , Ponikowski Piotr , Sabatine Marc S. , Schou Morten , Solomon Scott D. , Verma Subodh , Bengtsson Olof , Langkilde Anna Maria , Sjöstrand Mikaela , Vaduganathan Muthiah , Jhund Pardeep S. , McMurray John J.V. 
Published: April 2022

Background:
In a post hoc analysis, the frequency of occurrence of an early decline (dip) in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin and its association with outcomes were evaluated in patients with heart failure and reduced ejection fraction randomized in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial.

Methods:

Patients with heart failure with reduced ejection fraction with or without type 2 diabetes and an eGFR ≥30 mL·min
−1
·1.73 m
−2
were randomized to placebo or dapagliflozin 10 mg daily. The primary outcome was the composite of worsening heart failure or cardiovascular death. The extent of the dip in eGFR between baseline and 2 weeks, patient characteristics associated with a >10% decline, and cardiovascular outcomes and eGFR slopes in participants experiencing this decline were investigated. Time-to-event outcomes were assessed in Cox regression from 14 days; eGFR slopes were assessed with repeated-measures mixed-effect models.

Results:

The mean change in eGFR between day 0 and 14 was −1.1 mL·min
−1
·1.73 m
−2
(95% CI, −1.5 to −0.7) with placebo and −4.2 mL·min
−1
·1.73 m
−2
(95% CI, −4.6 to −3.9) with dapagliflozin, giving a between-treatment difference of 3.1 mL·min
−1
·1.73 m
−2
(95% CI, 2.6–3.7). The proportions of patients randomized to dapagliflozin experiencing a >10%, >20%, and >30% decline in eGFR were 38.2%, 12.6%, and 3.4%, respectively; for placebo, they were 21.0%, 6.4%, and 1.3%, respectively. The odds ratio for a >10% early decline in eGFR with dapagliflozin compared with placebo was 2.36 (95% CI, 2.07–2.69;
P
<0.001). Baseline characteristics associated with a >10% decline in eGFR on dapagliflozin were older age, lower eGFR, higher ejection fraction, and type 2 diabetes. The hazard ratio for the primary outcome in patients in the placebo group experiencing a >10% decline in eGFR compared with ≤10% decline in eGFR was 1.45 (95% CI, 1.19–1.78). The corresponding hazard ratio in the dapagliflozin group was 0.73 (95% CI, 0.59–0.91;
P
interaction
<0.001). A >10% initial decline in eGFR was not associated with greater long-term decline in eGFR or more adverse events.

Conclusions:
The average dip in eGFR after dapagliflozin was started was small and associated with better clinical outcomes compared with a similar decline on placebo in patients with heart failure with reduced ejection fraction. Large declines in eGFR were uncommon with dapagliflozin.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03036124.
Association of Change in Alcohol Consumption With Risk of Ischemic Stroke
Authors: Jeong Su-Min , Lee Han Rim , Han Kyungdo , Jeon Keun Hye , Kim Dahye , Yoo Jung Eun , Cho Mi Hee , Chun Sohyun , Lee Seung Pyo , Nam Ki-Woong , Shin Dong Wook 
Published: April 2022

Background:
The effect of serial change in alcohol consumption on stroke risk has been limitedly evaluated. We investigated the association of change in alcohol consumption with risk of stroke.

Methods:
This study is a population-based retrospective cohort study from National Health Insurance Service database of all Koreans. Four lakh five hundred thirteen thousand seven hundred forty-six participants aged ≥40 years who underwent 2 subsequent national health examinations in both 2009 and 2011. Alcohol consumption was assessed by average alcohol intake (g/day) based on self-questionnaires and categorized into non-, mild, moderate, and heavy drinking. Change in alcohol consumption was defined by shift of category from baseline. Cox proportional hazards model was used with adjustment for age, sex, smoking status, regular exercise, socioeconomic information, and comorbidities, Charlson Comorbidity Index, systolic blood pressure, and laboratory results. Subgroup analysis among those with the third examination was conducted to reflect further change in alcohol consumption.

Results:
During 28 424 497 person-years of follow-up, 74 923 ischemic stroke events were identified. Sustained mild drinking was associated with a decreased risk of ischemic stroke (adjusted hazard ratio, 0.88 [95% CI, 0.86–0.90]) compared with sustained nondrinking, whereas sustained heavy drinking was associated with an increased risk of ischemic stroke (adjusted hazard ratio, 1.06 [95% CI, 1.02–1.10]). Increasing alcohol consumption was associated with an increased risk of ischemic stroke (adjusted hazard ratio, 1.11 [95% CI, 1.06–1.17] from mild to moderate; adjusted hazard ratio, 1.28 [95% CI, 1.19–1.38] from mild to heavy) compared with sustained mild drinkers. Reduction of alcohol consumption from heavy to mild level was associated with 17% decreased risk of ischemic stroke through 3× of examinations.

Conclusions:
Light-to-moderate alcohol consumption is associated with a decreased risk of ischemic stroke, although it might be not causal and could be impacted by sick people abstaining from drinking. Reduction of alcohol consumption from heavy drinking is associated with a decreased risk of ischemic stroke.
Impact of Previous Stroke on Clinical Outcome in Elderly Patients With Nonvalvular Atrial Fibrillation: ANAFIE Registry
Authors: Yoshimoto Takeshi , Toyoda Kazunori , Ihara Masafumi , Inoue Hiroshi , Yamashita Takeshi , Suzuki Shinya , Akao Masaharu , Atarashi Hirotsugu , Ikeda Takanori , Okumura Ken , Koretsune Yukihiro , Shimizu Wataru , Tsutsui Hiroyuki , Hirayama Atsushi , Yasaka Masahiro , Maruyama Hirofumi , Teramukai Satoshi , Kimura Tetsuya , Morishima Yoshiyuki , Takita Atsushi , Yamaguchi Takenori 
Published: April 2022

Background:
We determined the long-term event incidence among elderly patients with nonvalvular atrial fibrillation in terms of history of stroke/transient ischemic attack (TIA) and oral anticoagulation.

Methods:
Patients aged ≥75 years with documented nonvalvular atrial fibrillation enrolled in the prospective, multicenter, observational All Nippon Atrial Fibrillation in the Elderly Registry between October 2016 and January 2018 were divided into 2 groups according to history of stroke/TIA. The primary end point was the occurrence of stroke/systemic embolism within 2 years, and secondary end points were major bleeding and all-cause death within 2 years. Cox models were used to determine whether there was a difference in the hazard of each end point in patients with/without history of stroke/TIA, and in ischemic stroke/TIA survivors taking direct oral anticoagulants versus those taking warfarin.

Results:
Of 32 275 evaluable patients (13 793 women [42.7%]; median age, 81.0 years), 7304 (22.6%) had a history of stroke/TIA. The patients with previous stroke/TIA were more likely to be male and older and had higher hazard rates of stroke/systemic embolism (adjusted hazard ratio, 2.25 [95% CI, 1.97–2.58]), major bleeding (1.25, 1.05–1.49), and all-cause death (1.13, 1.02–1.24) than the other groups. Of 6446 patients with prior ischemic stroke/TIA, 4393 (68.2%) were taking direct oral anticoagulants and 1668 (25.9%) were taking warfarin at enrollment. The risk of stroke/systemic embolism was comparable between these 2 groups (adjusted hazard ratio, 0.90 [95% CI, 0.71–1.14]), while the risk of major bleeding (0.67, 0.48–0.94), intracranial hemorrhage (0.57, 0.39–0.85), and cardiovascular death (0.71, 0.51–0.99) was lower among those taking direct oral anticoagulants.

Conclusions:
Patients aged ≥75 years with nonvalvular atrial fibrillation and previous stroke/TIA more commonly had subsequent ischemic and hemorrhagic events than those without previous stroke/TIA. Among patients with previous ischemic stroke/TIA, the risk of hemorrhagic events was lower in patients taking direct oral anticoagulants compared with warfarin.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique Identifier: UMIN000024006.
The Satanic Verses and Evil in Babylonia
Authors: Boyarin Daniel 
Published: April 2022

Abstract
In this article, I study several midrashic passages preserved in the Babylonian Talmud that deal with Satan. The verses that they are based on are nearly all drawn from the book of Job. I find that these midrashim strongly support the conclusions of Ishay Rosen-Zvi’s monograph Demonic Desires in several ways, notably that Satan is not the font and origin of evil in the world as he is in other branches or wings of the ancient Jewish imagination.
Secrets of Qohelet: Toward an Exegetical History of a Biblical Text during the Middle Ages
Authors: Robinson James Theodore 
Published: April 2022

Abstract
During the middle ages and early modern period, dozens of Jewish commentaries were written on Qohelet, in Arabic and Hebrew, and representing a very full range of methods and approaches, from Karaite to Rabbanite, grammatical to pietistic, Neoplatonic, Aristotelian, and anti-Aristotelian, even kabbalistic. The purpose of this article – dedicated to the memory of Kalman Bland – is to present some experiments related to the telling of the history of medieval Jewish exegesis of Qohelet in hermeneutical context.
Spiritual Pedagogy and Rhetoric in a Ḥasidic Homily: The Maʾor va-Shemesh on Parshat Qedoshim
Authors: Fishbane Michael 
Published: April 2022

Abstract
A close analysis of a Ḥasidic homily by R. Kalonymos Kalman Epstein of Krakow, author of Maʾor va-Shemesh. The essay focuses on rhetoric, structure, and thematic content. The role of hermeneutics is engaged throughout.
70 years of herpetology in India: insights into shifts in focal research areas and gender ratios among authors
Authors: Cyriac Vivek Philip , Dharwadkar Sneha , Mital Anuja , Mohan Ashwini Venkatanarayana 
Published: April 2022

Abstract
Herpetology in India took off during the British colonial rule with the documentation of herpetofauna. Several studies have outlined the early history of Indian herpetology; however, few have traced the growth of this field since India’s independence. We analyse trends in Indian herpetology focusing on taxa, subfields, and authorship over the last 70 years. Of the 1177 published articles we analysed, 64.9% studied reptiles, 26.5% studied amphibians and 8.6% were general herpetofaunal studies. Frogs, lizards, and snakes being the most diverse herpetofauna groups, each accounted for 20-21% of the published articles and significantly outnumber publications on caecilians (2.3%), salamanders (0.4%), chelonians (12.6%), and crocodiles (4.4%). We found a significantly greater number of publications on Diversity & Distribution (34.2%), Taxonomy & Systematics (21.6%) and Ecology (19.4%) compared to other subfields, and detected a decline in Development, Physiology & Cytology and Evolutionary biology studies over the last four decades (1980-2019). The gender ratio among co-authors was dominated by men with only 29.7% of publications containing women authors. The overall proportion of women authors has not changed significantly over decades, but our analyses detected a significant decrease in women first authors and the proportion of women authors when the corresponding authors were men. Women authors were substantially lower in the subfield of Taxonomy & Systematics, and women published significantly more on amphibians compared to reptiles. Overall, we highlight the growth of herpetology in India from two key viewpoints, scientific pursuits, and gender parity among herpetologists.
Vestiges of the Huns? The Radiocarbon-Based Chronology of the Trilobate Arrowheads from Plinkaigalis Cemetery, Central Lithuania
Authors: Kurila Laurynas , Piličiauskienė Giedrė , Ežerinskis Žilvinas , Šapolaitė Justina , Garbaras Andrius 
Published: April 2022

Abstract
Until presently, over 60 trilobate arrowheads characteristic of Asian nomads have been found in Lithuanian hillforts or their adjacent settlements, some of them in destruction layers. These finds encouraged Lithuanian archaeologists to create a narrative about the Huns severely raiding into the region in the 5th century AD. However, it is accepted as an axiom rather than a topic for research due to the lack of precise chronology. From the Plinkaigalis cemetery, extremely rare finds are known; two trilobate arrowheads were found embedded in human bones (both were from group burials, where other signs of violent trauma were encountered). These finds offered the unique possibility of radiocarbon dating skeletal material directly related to trilobate arrowheads, providing new insights into the narrative of the Huns’ attack. The results of a set of AMS 14C dates are presented and discussed in the article.
Spiritual Technologies
Authors: Jalobeanu Dana , Matei Oana 
Published: April 2022

Abstract
Cider making does not strike one as much of a philosophical enterprise. However, in England, in the second part of the seventeenth-century, many natural philosophers were actively involved in it. This paper investigates the philosophical premises and methodological underpinning of this enterprise, showing that cider-making developed as a branch of applied Baconian science. We show that the grand-scale project of cider making shared a background theory of Baconian inspiration and was conceived in terms of Bacon’s rules and methods of experimenting and collaborative data-sharing. With this Baconian theoretical and methodological framework, naturalists involved in this enterprise selected and tried old recipes, experimented with new ones, and turned cider-making into an early modern technology. Central to this technology was the idea that, in the process of cider-making, the naturalist manipulates the living spirits of the vegetal world, enclosing them in a bottle.