bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNAs in Various Body Fluids and their Importance in Forensic Medicine
Authors: Das Srijit , Teoh Seong Lin 
Published: March 2022

Abstract:
MicroRNAs (miRNAs) are a class of non-coding RNAs that regulate gene expression. miRNAs have tissue-specific expression and are also present in various extracellular body fluids, including blood, tears, semen, vaginal fluid, and urine. Additionally, the expression of miRNAs in body fluids is linked to various pathological diseases, including cancer and neurodegenerative diseases. Examination of body fluids is important in forensic medicine as they serve as a valuable form of evidence. Due to its stability, miRNA offers an advantage for body fluid identification, which can be detected even after several months or from compromised samples. Identification of unique miRNA profiles for different body fluids enables the identification of the body fluids. Furthermore, miRNAs profiling can be used to estimate post-mortem interval. Various biochemical and molecular methods used for the identification of miRNAs have shown promising results. We discuss different miRNAs as specific biomarkers and their clinical importance in different pathological conditions, as well as their medicolegal importance.
Predicting the Overall Survival in Patients with Advanced Pancreatic
Cancer by Calculating L3 Skeletal Muscle Index Derived from CT
Authors: Özkul Bahattin , Özkul Özlem , Bilir Cemil 
Published: March 2022

Background:
Pancreatic cancer is mostly diagnosed in advanced stages, and treatment results
are not satisfactory. L3 skeletal muscle index (SMI) has emerged as a prognostic factor in pancreatic
cancer patients. We aimed to assess the association between sarcopenia and overall survival in
patients with pancreatic cancer in this study.

Methods:
Patients who were admitted to the Department of Oncology between March 2012 and December
2019 and diagnosed with pancreatic cancer were evaluated. The computerized tomography
images and laboratory parameters of a total of 115 patients were included in this retrospective singlecenter
study. We defined sarcopenia as an SMI <43,56 cm²/m² for females and <56,44 cm²/m² for
males using the receiver operating characteristics (ROC) curve in the study population. Univariate and
multivariate analyses were performed by using Cox-regression modelling, and survival curves were
constructed by using Kaplan-Meier method.

Results:
70% of the patients were male, and the mean age was 64.9±9.9 years (mean ± SD). 70.6% of
female patients and 67.9% of male patients were diagnosed with stage 4 cancer. The prevalence of
sarcopenia in the whole patient group was 29.6%. By multivariate analysis, SMI (p=0.009) and advanced
stage (p=0.003) were found as poor prognostic factors for overall survival (OS). The neutrophil
to lymphocyte ratio (NLR) was statistically significantly higher in sarcopenic patients than in nonsarcopenic
patients (p=0.031).

Conclusion:
Patients having sarcopenia at the time of diagnosis may demonstrate poorer overall survival
of pancreatic cancer, and SMI may be considered as a potential prognostic factor.
Evidence and Updates on Non-dairy Synbiotic Beverage Development
Authors: Andrade Rhaissa Coelho , Figueredo Caroline Santana , de Carvalho Alves Janaina , Roselino Mariana Nougalli 
Published: March 2022

Background:
With the increase in cases of intolerance and allergies to milk protein,
new food possibilities have been studied as an alternative to dairy drinks in order to
meet the needs of this population, such as non-dairy synbiotic drinks.

Objective:
The aim of this study was to carry out an integrative literature review on the
main types of non-dairy synbiotic beverages in order to investigate the probiotics and
prebiotics added to them. Besides, we also looked into the characteristics of the substrates
and fermentation conditions (temperature, time, and pH) to assess the influences on bacterial
viability, consumer acceptance, conservation, and antimicrobial action.

Methods:
We conducted an integrative review of articles published in Pubmed, Web of
Science, Scielo, Scopus, and Capes journals in the last five years, using the following
terms: symbiotic drink, symbiotic beverage, synbiotic drink, synbiotic beverage, bebida
simbiótica, not kombucha, which resulted in the inclusion of 28 articles.

Results:
As expected, the main probiotics were lactobacillus and bifidobacterium, while
the prebiotics were inulin and fructooligosaccharide. It is noteworthy that all analyzed beverages
were, in fact, probiotics since they had values above the minimum viability of 6 log
CFU/mL; consequently, they can bring benefits to consumers.

Conclusion:
In addition to being rich sources of nutrients, fruits and vegetables also enable
the development of synbiotic drinks supplied from their substrates, providing an alternative
for people who are lactose intolerant.
Evaluation of Brain Targeting Potential of Zolmitriptan Mucoadhesive
Nanoparticles for Intranasal Drug Delivery
Authors: Jha Sunena , Mishra Dinanath 
Published: March 2022

Background:
Hydrophilic drugs are poor applicants for brain targeting via oral route
due to the presence of a blood-brain barrier that allows only small lipophilic molecules to freely
access the brain. Due to unique anatomical connections between the nasal cavity and the brain,
intranasal administration can be explored for drug delivery to the brain directly that circumvents
the blood-brain barrier too.

Objectives:
Zolmitriptan is a widely used antimigraine drug, and its brain targeting by nasal route
in the form of mucoadhesive nanoparticles is more effective in migraine treatment as it provides
fast relief and good bioavailability as compared to its oral drug delivery. In the present study,
zolmitriptan mucoadhesive nanoparticles were prepared to improve the bioavailability and brain
targeting for the better management of Migraine attacks.

Methods:
The mucoadhesive polymeric nanoparticles of zolmitriptan were formulated by a modified
ionic gelation method using thiolated chitosan. The pharmacokinetic parameters were counted
in male Wistar rats by intranasal and oral delivery of the anti-migraine drug zolmitriptan and compared
statistically. The concentration of zolmitriptan in the blood plasma and brain samples was
determined by using the liquid-liquid extraction method followed by a reversed-phase highperformance
liquid chromatography (RP-HPLC) analysis. The pharmacodynamic analysis was
conducted in adult male Swiss albino mice by behavioral models, a light/dark box model, and acetic
acid-induced writhing (abdominal stretching or constriction). These tests were used to reproduce
the important associated symptoms of migraine viz. hyperalgesia (nociceptive sensitization)
and photophobia to assess the therapeutic potential of intranasal delivery of nanoparticles antimigraine
activity.

Results:
The absolute bioavailability accessed for Zolmitriptan nanoparticles by IN route was
found to be very high (193%), suggesting that the sufficient amount of drug transported by nanoparticles
and DTE ratio was calculated as 2.8. Moreover, it revealed better nose-to-brain transport
by zolmitriptan nanoparticles as compared to oral delivery in male Wistar rats. A significant increase
in the tolerance capacity of animals to bright light and a fall in the number of stretching in
mice suggested the better management of migraine-associated symptoms by the zolmitriptan nanoparticles.

Conclusion:
Thus, the present study confers the significance of nasal drug delivery for brain targeting
of zolmitriptan nanoparticles for the treatment of migraine.
Microwave Sol-gel Synthesis of Co, Ni, Cu, Mn Ferrites and the Investigation
of Their Activity in the Oxidation Reaction of Carbon Monoxide
Authors: Zulfugarova Sima Mamed , Ramiz Azimova Gunel , Fikret Aleskerova Zuleyxa , Humbat Ismailov Etibar , Nikolayevich Litvishkov Yuriy , Babir Tagiyev Dilqam 
Published: March 2022

Background:
The study effect of microwave radiation on the catalytic properties of
transition metal ferrites synthesized by ceramic and sol-gel methods in the oxidation reaction of
carbon monoxide into dioxide.

Objective:
This work aims to study the effect of microwave radiation on the production of cobalt,
copper, nickel, and manganese ferrites by sol-gel combustion technology using various organic
reagents and to study their catalytic activity in the oxidative conversion of carbon monoxide into
dioxide.

Methods:
Microwave treatment was carried out on a setup based on an EM-G5593V microwave
oven (Panasonic) with a magnetron power varying from 300 to 800 W with an operating frequency
of 2450 MHz. X-ray phase analysis of the products was carried out on a Bruker D 2Phazer automatic
diffractometer. The measurement of the specific surface area of the samples was determined
by low-temperature nitrogen adsorption by the multipoint BET method on a SORBI-MS instrument
(ZAO META, Russia). IR spectra were recorded using FT-IR LUMOS Bruker spectrometers.
The micrographs of samples were analyzed on the Sigma VP (Carl Zeiss Jena) equipment.

Results:
It was determined that the most active catalysts for the oxidation of carbon monoxide to
dioxide are ferrites obtained by the sol-gel combustion method using microwave radiation to "ignite"
the gel.

Conclusion:
The use of microwave radiation in the preparation of ferrites by the sol-gel method
with combustion can initiate a self-propagating exothermic combustion reaction in the entire volume
of the sample in a very short time, measured in seconds. The catalytic activity in the oxidative
conversion of carbon monoxide obtained by this method of ferrites is comparable to the activity of
ferrites obtained by the sol-gel method with traditional combustion.
Token Economy–Based Hospital Bed Allocation to Mitigate Information Asymmetry: Proof-of-Concept Study Through Simulation Implementation
Authors: Hiragi Shusuke , Hatanaka Jun , Sugiyama Osamu , Saito Kenichi , Nambu Masayuki , Kuroda Tomohiro 
Published: March 2022

Background
Hospital bed management is an important resource allocation task in hospital management, but currently, it is a challenging task. However, acquiring an optimal solution is also difficult because intraorganizational information asymmetry exists. Signaling, as defined in the fields of economics, can be used to mitigate this problem.

Objective
We aimed to develop an assignment process that is based on a token economy as signaling intermediary.

Methods
We implemented a game-like simulation, representing token economy–based bed assignments, in which 3 players act as ward managers of 3 inpatient wards (1 each). As a preliminary evaluation, we recruited 9 nurse managers to play and then participate in a survey about qualitative perceptions for current and proposed methods (7-point Likert scale). We also asked them about preferred rewards for collected tokens. In addition, we quantitatively recorded participant pricing behavior.

Results
Participants scored the token economy–method positively in staff satisfaction (3.89 points vs 2.67 points) and patient safety (4.38 points vs 3.50 points) compared to the current method, but they scored the proposed method negatively for managerial rivalry, staff employee development, and benefit for patients. The majority of participants (7 out of 9) listed human resources as the preferred reward for tokens. There were slight associations between workload information and pricing.

Conclusions
Survey results indicate that the proposed method can improve staff satisfaction and patient safety by increasing the decision-making autonomy of staff but may also increase managerial rivalry, as expected from existing criticism for decentralized decision-making. Participant behavior indicated that token-based pricing can act as a signaling intermediary. Given responses related to rewards, a token system that is designed to incorporate human resource allocation is a promising method. Based on aforementioned discussion, we concluded that a token economy–based bed allocation system has the potential to be an optimal method by mitigating information asymmetry.
THE COMPLEXITY PARADIGM: TOWARDS A MODEL FOR THE ANALYSIS OF SOCIAL SYSTEMS AND PROBLEMS
Authors: Parreira Artur , Silva Ana Lorga 
Published: March 2022

The article proposes the complexity paradigm as an innovative reasoning for analyzing problems in behavioral sciences. It begins to explain the contributions of the major authors of the complex reasoning paradigm: Gödel, Prigogine and Morin. They offer the basis to a model of analysis and assessment of complex systems and problems (ACSIP Model). The four postulates of the Model are explained, emphasizing the principal hypothesis of the Model – the level of cognitive operations is the most important factor of complexity of a system; then to understand it, the cognitive level of analysis must be at minimum equal to that of the system or the problem under analysis. In the second part the article, an illustrative application of the ACSIP Model is applied to the analysis of the SDG 9 from the UN 20/30 agenda, showing the analysis of a complex problem, guided by the complexity reasoning model. Following that, an empirical research is presented, to verify the hypothesis underlying the fourth postulate of the model. The results confirm the hypothesis: the use of information by a group is inversely proportional to the use of power (authority). These results allow us to conclude that the complex reasoning paradigm is a promising tool to obtain synergic results in the scientific analysis and resolution of concrete social problems and to face the complex challenges brought by artificial intelligence systems.
Gambaran Kualitas Hidup Pasien dengan Keluhan Dispepsia yang Diberi Perawatan dengan Jamu (Data Registri Jamu 2014-2018)
Authors: Lestari Tri Wahyuni , Prihartini Nita , Delima Delima 
Published: March 2022

Abstrak
Registri jamu merupakan sistem pencatatan pelayanan kesehatan menggunakan jamu atau herbal berbasis web yang dikembangkan oleh Balitbangkes. Artikel ini bertujuan mengetahui gambaran kualitas hidup pasien dengan keluhan dispepsia yang diberi jamu oleh dokter praktik jamu. Desain penelitian Registri Jamu yaitu potong lintang. Data dikumpulkan dari data rekam medik 186 pasien dispepsia yang berobat pada 64 dokter yang termasuk dalam jejaring dokter praktik jamu di 10 provinsi di Indonesia tahun 2014—2018. Data diekstrak dari sistem pencatatan Registri Jamu dan dianalisis secara deskriptif. Kualitas hidup dinilai menggunakan instrumen kualitas hidup 4 dimensi (8 pertanyaan) dan skala Nepean khusus dispepsia. Hasil analisis menunjukkan sebagian besar pasien dispepsia yang berobat pada dokter praktik jamu adalah perempuan, usia 45—64 tahun, pendidikan tamat perguruan tinggi, pekerjaan wiraswasta, berobat pada fasyankes klinik, berada di provinsi Jawa Tengah. Enam gejala umum dispepsia terbanyak yaitu: tidak nafsu makan, lemah/letih, sulit tidur, nyeri ulu hati, demam, dan pucat. Kualitas hidup pasien dengan keluhan dispepsia yang diberi perawatan dengan jamu oleh dokter praktik jamu cenderung rmeningkat seiring dengan bertambahnya frekuensi waktu kunjungan.
Kata kunci: dispepsia, registri jamu, kualitas hidup
Abstract
Jamu Registry is a web-based health service recording system developed by Balitbangkes. This article aims to describe the quality of life of patients with dyspepsia treated with jamu by doctors. Research on Jamu Registry was a cross-sectional study. Data was collected from medical record of 186 dyspepsia patients treated by 64 doctors prescribing herbal medicine in their services in 10 provinces in Indonesia from 2014—2018. This data was extracted from the Jamu Registry recording system and analyzed descriptively. The quality of life was assessed using 4 dimensions (8 items) quality of life questionnaire and Nepean scale for dyspepsia. The results showed dyspepsia patients in this study were mostly female, aged 45—64 years, highly educated, worked as an entrepreneur, sought treatment at clinical health facility, located in Central Java province. The six common symptoms of dyspepsia recorded were: lack of appetite, weakness / fatigue, sleep disorders, heartburn, fever and pallor. The quality of life of patients with dyspepsia who were given jamu by the herbal medicine practitioner tended to increase along with the frequency of visit.
Keywords: dyspepsia, herbal medicine registry, quality of life
Experimental study of the hydraulic jump length in a smooth trapezoidal channel
Authors: Ngoc Nguyen Minh , Cuong Pham Hong , Son Tran Thanh , Nam Nguyen Van , Phong Nguyen Thanh 
Published: March 2022

The paper showed the result of investigation of the hydraulic jump length in a trapezoidal channel. In this study, the basic factors that affect the length (Lj) and roller length (Lr) of the hydraulic jump were investigated by a physical trapezoidal channel’s model. The experiment carried out in purpose to establish a new empirical equation for calculating the roller length (Lr) of the jump in the horizontal trapezoidal channel with the upstream Froude number 4.0 to 9.0 (the steady jump). The hydraulic characteristics of forced jump were measured and statistically calculated using MS Excel software. The results of data analysis showed that the MAPE was relatively small (< 5%), and R2 > 0.9 (strong correlation between predicted and observed values) and other statistical indicators are less than 0.1 (MSE = 0.004, RMSE = 0.062, MEA = 0.047). Therefore, the equation found could be appropriated and applied to calculate characteristics of hydraulic jump trapezoidal channel.
Calila e Dimna como instrumento de memoria alfonsí y las narrativas epigráficas en la Estoria de España
Authors: Becker Ulrike 
Published: March 2022

Calila e Dimna –en su calidad de espejo de príncipes de origen oriental y primera traducción de un texto narrativo en prosa por orden del infante Alfonso (1251)– proporciona un fondo de estrategias de construcción de la memoria regia. Partiendo de manera paradigmática del capítulo “Del fijo del rey e del fidalgo e de sus compañeros”, y teniendo en cuenta su raíz transcultural, es instructivo relacionar los métodos respectivos descritos en Calila e Dimna con los procedimientos de los escritos historiográficos encargados por Alfonso más tarde como rey, en particular aquellos en la Estoria de España. Ambos textos contienen secuencias narrativas que reproducen inscripciones ficticias. Estas inscripciones, su puesta en escena y las narrativas de poder inherentes se analizarán en este estudio con respecto a la memoria política y a las implicaciones en la cultura política del reinado alfonsí. Las medidas mediáticas destinadas a conservar la memoria del monarca a través de la epigráfica, que abarcan desde aspectos genealógicos hasta monumentos funerarios, suelen servir, asimismo, como legitimación del señorío.
Instagram as a Promotion Media at the Katakerja Library
Authors: HR Muslihatul Inayah , Tahir Gustia , Abidin Saenal 
Published: March 2022

Peluang media sosial yang begitu besar menjangkau audiens membuat perpustakaan tidak ingin menyia-yiakan peluang yang ada. Penelitian ini membahas tentang bagaimana pemanfaatan media sosial Instagram sebagai sarana promosi Perpustakaan Katakerja di Kota Makassar dan apa kendala Perpustakaan Katakerja di Kota Makassar dalam pemanfaatan Instagram. Adapun jenis penelitian ini yakni deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Data dianalisis dan diolah dengan metode reduksi data, penyajian data secara tertulis, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa dalam pemanfaatan media sosial Instagram sebagai sarana promosi Perpustakaan Katakerja di Kota Makassar dinilai sudah maksimal karena sejauh ini semua fitur-fiturnya dimanfaatkan oleh Perpustakaan Katakerja yang menggunakan nama pengguna @katakerja dengan konten yang dibagikan berupa segala kegiatan yang terkait dengan Perpustakaan Katakerja semacam layanan perpustakaan, kegiatan diskusi atau kelas, keanggotaan, koleksi, merchandise, sudut-sudut ruangan, dan kunjungan pemustaka yang dibagikan ke pengikut Instagram Perpustakaan Katakerja. Adapun kendala yang dihadapi Perpustakaan Katakerja yakni kurangnya koordinasi tim sehingga berdampak pada pengunggahan yang tidak berjalan lancar dan tidak adanya biaya pengelolaan media sosial Instagram dalam promosi Perpustakaan Katakerja.ABSTRACTThe opportunity for social media to reach an audience is so great that libraries do not want to waste existing opportunities. This research discusses how the use of Instagram as a means of promoting the Katakerja Library in Makassar City and what are the obstacles obstacles faced by its library. The type of this research is descriptive with a qualitative approach. Data collection techniques using interviews, observation and documentation. The data were analyzed and processed using data reduction methods, written data presentation, and documentation. The results show that the use of Instagram is fully conclutions as a means of promoting the Katakerja Library in Makassar City is considered to be maximal because its features have been utilized by the Katakerja Library (@katakerja) to promote library services, discussion or class activities, memberships, collections, merchandise, room corners, and visitor fot its library followers. Meanwehile There are obstacles faced by the library, namely the lack of team coordination so that it has an impact on uploads that do not run smoothly and there is no budgat for managing Instagram in promoting the library.
Response model for the psychological education of college students based on nonlinear finite element equations
Authors: Guanglei Zhang , Altalbe Ali 
Published: March 2022

Abstract
This article proposes a mental health education model for college students based on non-linear finite element equations and explores the concepts, content, methods and approaches for mental health education. After analysing college students’ psychological behaviours, the study is based on stressors and stress response models. It specifically explores the psychological and behavioural manifestations of college students with four different attachment types. The research provides a preliminary theoretical basis for the mechanism of the psychological and physical health of college students.
Off-Vertical Axis Rotational Assessment of Transdermal Scopolamine for Motion Sickness Prophylaxis
Authors: Woodard Daniel , Knox Glenn , Wood Scott , DiBiase Cathy 
Published: March 2022

Abstract
The objectives of this study were to evaluate transdermal scopolamine for motion sickness prophylaxis, and to evaluate off-vertical axis rotation (OVAR) as a laboratory model of motion sickness. This was a randomized, prospective, double-blind study design, set in a vestibular research laboratory. The experimental subjects consisted of 12 patients – 7 male, 5 female – ages 21 to 57, with normal auditory/vestibular function. The intervention was off-vertical axis rotation 20 degrees in the dark after administration of transdermal scopolamine or placebo. The main outcome measures were time duration of tolerated off-vertical rotation, and subjective symptom reporting during rotation at one-minute intervals on a 0–4 scale. Results were as follows: patients treated with transdermal scopolamine had statistically significant improved tolerance time to off-vertical axis rotation. Reported symptom-atology on the 0–4 subjective symptom scale was significantly improved, as compared to placebo, and was dose-dependent. Conclusions are as follows: off-vertical axis rotation is a useful modality for the evaluation of motion sickness medications. Transdermal scopolamine showed statistically significant dose-dependent effects in mitigating OVAR-induced motion sickness symptomatology and was well tolerated.