bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity
Authors: Ohyama Sadao , Ouchi Takehito , Kimura Maki , Kurashima Ryuya , Yasumatsu Keiko , Nishida Daisuke , Hitomi Suzuro , Ubaidus Sobhan , Kuroda Hidetaka , Ito Shinichirou , Takano Masayuki , Ono Kentaro , Mizoguchi Toshihide , Katakura Akira , Shibukawa Yoshiyuki 
Published: December 2022

According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface. Recent convergent evidence in Vitro has shown that plasma membrane deformation, mimicking dentinal fluid movement, activates mechanosensitive transient receptor potential (TRP)/Piezo channels in odontoblasts, with the Ca2+ signal eliciting the release of ATP from pannexin-1 (PANX-1). The released ATP activates the P2X3 receptor, which generates and propagates action potentials in the intradental Aδ afferent neurons. Thus, odontoblasts act as sensory receptor cells, and odontoblast-neuron signal communication established by the TRP/Piezo channel-PANX-1-P2X3 receptor complex may describe the mechanism of the sensory transduction sequence for dentinal sensitivity. To determine whether odontoblast-neuron communication and odontoblasts acting as sensory receptors are essential for generating dentinal pain, we evaluated nociceptive scores by analyzing behaviors evoked by dentinal sensitivity in conscious Wistar rats and Cre-mediated transgenic mouse models. In the dentin-exposed group, treatment with a bonding agent on the dentin surface, as well as systemic administration of A-317491 (P2X3 receptor antagonist), mefloquine and 10PANX (non-selective and selective PANX-1 antagonists), GsMTx-4 (selective Piezo1 channel antagonist), and HC-030031 (selective TRPA1 channel antagonist), but not HC-070 (selective TRPC5 channel antagonist), significantly reduced nociceptive scores following cold water (0.1 ml) stimulation of the exposed dentin surface of the incisors compared to the scores of rats without local or systemic treatment. When we applied cold water stimulation to the exposed dentin surface of the lower first molar, nociceptive scores in the rats with systemic administration of A-317491, 10PANX, and GsMTx-4 were significantly reduced compared to those in the rats without systemic treatment. Dentin-exposed mice, with somatic odontoblast-specific depletion, also showed significant reduction in the nociceptive scores compared to those of Cre-mediated transgenic mice, which did not show any type of cell deletion, including odontoblasts. In the odontoblast-eliminated mice, P2X3 receptor-positive A-neurons were morphologically intact. These results indicate that neurotransmission between odontoblasts and neurons mediated by the Piezo1/TRPA1-pannexin-1-P2X3 receptor axis is necessary for the development of dentinal pain. In addition, odontoblasts are necessary for sensory transduction to generate dentinal sensitivity as mechanosensory receptor cells.
Need dissatisfaction and its consequences on support for anti-pandemic behaviors in China: The mediation of attribution and local government satisfaction, and the moderation of social class
Authors: Zhang Yan , Wang Junxiu 
Published: December 2022

IntroductionThe COVID-19 pandemic has greatly impacted the global economy, resulting in a substantial increase in inequality. There is a need to understand need dissatisfaction in this context, its group differences, and its consequences on support for anti-pandemic behaviors.MethodsUsing data from a survey round of the Chinese Social Mentality Survey from 21 April to 26 May 2022, 6,022 participants aged between 18 and 70 years (M = 32.27;SD = 8.74; men = 46.76%) from 29 provinces of Mainland China were included in the study.Results1) Need dissatisfaction was negatively related with support for anti-pandemic behaviors and was completely mediated by attribution and local government satisfaction. 2) Internal/external attribution acted as a double-edged sword: they were negatively/positively related with support for anti-pandemic behaviors, while they became positively/negatively related with support for anti-pandemic behaviorsviathe mediation of local government satisfaction. 3) People who were unemployed and in the subjectively middle class reported higher need dissatisfaction and less support for anti-pandemic behaviors compared to their counterparts. 4) Social class moderated the relationship between need dissatisfaction and internal attribution: when needs were dissatisfied, participants with higher income and subjective social class tended to attribute more internally.DiscussionThis study contributes to the attribution theory and social identity theory in the context of major global public health events and provides practical implications for promoting behavioral compliance in the context of COVID-19. In particular, facilitating a positive interaction between the public and local governments may be helpful to create a shared identity and, ultimately, prevent and control the pandemic together.
PTSD and depressive symptoms in Chinese adolescents exposed to multiple stressors from natural disasters, stressful life events, and maltreatment: A dose-response effect
Authors: Ni Ting , Zhang Yi , Xue Shuang , Xu Wenjian , Tang Wanjie 
Published: December 2022

ObjectivesLittle is known about the effects and the extent that childhood adversity has on post-traumatic stress disorder (PTSD) and depression.Study designA population-based, epidemiological study from the Wenchuan earthquake.MethodsA total of 5,195 Wenchuan Earthquake adolescent survivors aged 11–18 years from nine high schools in southwest China completed questionnaires that assessed their PTSD and depression symptoms due to childhood maltreatment, stressful life events, and childhood earthquake exposure.ResultsThe PTSD and depression prevalences were 7.1 and 32.4%. After controlling for age and gender, the multiple linear regressions revealed that stressful life events had the most significant direct effect on depression (β = 0.491), followed by childhood emotional abuse (β = 0.085), and earthquake exposure (β = 0.077). Similarly, stressful life events (β = 0.583) were found to have more significant direct effects on PSTD, followed by earthquake exposure (β = 0.140); however, childhood emotional abuse was not found to have an effect. The structural equation modeling (SEM) revealed that there were interactions between the three childhood adversities, with all three concurrently affecting both PTSD and depression.ConclusionThese findings add weight to the supposition that psychological maltreatment, negative life events, and earthquake exposure contribute to PTSD and depression. In particular, the identification of subgroups that have a high prevalence of these childhood adversities could assist professionals to target populations that are at high risk of mental health problems.
Impact of organizational characteristics on employees’ entrepreneurial orientation with mediating role of knowledge process capabilities and moderating role of psychological factors in the era of COVID-19
Authors: Basheer Muhammad Farhan , Sabir Saeed Ahmad , Raoof Rabeeya , Hameed Waseem Ul , Jabeen Saida 
Published: December 2022

PurposeThe study aims to investigate the impact of organizational characteristics and knowledge process capabilities on the entrepreneurial orientation among the manufacturing industry employees in the Punjab province of Pakistan. Additionally, this study has examined the mediating role of knowledge process capabilities in the relationship between organizational characteristics and entrepreneurial orientation among those employees and the moderating effect of psychological factors on the relationship between organizational characteristics and entrepreneurial orientation.Design, methodology, and approachThe study has employed the survey-based methodology and data are collected with the aid of self-administered questionnaires. This study utilized the partial least squares structural equation modeling (PLS-SEM) to establish the validity and reliability of the measurement model and test the relationships. The response rate of the current study is 64.66%.FindingsThe study findings have shown mixed results as one of the organizational characteristics, namely, resource and time availability is an insignificant determinate of entrepreneurial orientation among the manufacturing industry employees in Punjab province of Pakistan. Whereas management support, rewards, work discretion, and knowledge process capabilities appear as significant determinates of employees’ entrepreneurial orientation. The results indicated that knowledge process capabilities have a mediating role in the relationship between organizational characteristics and employees’ entrepreneurial orientation. Moreover, psychological factors, namely, propensity to take risk and locus of control have a significant moderating role on the relationship of management support, rewards, and work discretion with employees’ entrepreneurial orientation.Practical implicationsThe empirical insights on the study are valuable for policymakers and managers in manufacturing sectors of developing countries, such as Pakistan, to enrich their work performance through the understanding impact of organizational characteristics and knowledge process capabilities on the entrepreneurial orientation with moderating role of psychological factors.Originality and valueStudies on the mediating impact of knowledge process capabilities on the linkage between organizational characteristics and entrepreneurial orientation with the moderating role of psychological factors remain limited. This study is one of the earliest studies that investigate these inter-relationships.
Exploring the effects of seasons, diurnal cycle, and heights on airborne pollen load in a Southeast Asian atmospheric condition
Authors: Juprasong Yotin , Sirirakphaisarn Sirin , Siriwattanakul Umaporn , Songnuan Wisuwat 
Published: December 2022

IntroductionAeropollen can induce detrimental effects, particularly in respiratory airways. Monitoring local aeropollen is essential for the management of pollen allergic patients in each area. However, without resources for constant monitoring, pollen counts are subjected to biases imposed by the choices of sampling season, time of collection, and location. Therefore, the effects of these factors must be better understood. This study investigated the dynamics of aeropollen types through seasonal variation, diurnal cycle and different heights from the ground in Bangkok, Thailand.MethodsAeropollen samples were collected for 12 months at the Faculty of Science, Mahidol University in Bangkok, using a RotoRod Sampler®. For the investigation of diurnal effect, pollen was collected at 7 a.m., 10 a.m., 1 p.m., 4 p.m., and 7 p.m. For the study of height effect, data were collected at 2, 10, and 18 meters above ground.Results and discussionThis is the first study of the effects of diurnal cycle and height variation on airborne pollen count in Southeast Asia. The results showed the highest concentration of aeropollen was observed in November, which was at the beginning of the northeast monsoon season in Bangkok, whereas the lowest concentration was recorded in July (rainy season). Interestingly, the lowest airborne pollen concentration recorded in July was greater than the high level of most standards. Grass pollen was found as the major aeropollen. The highest total pollen concentration was detected at 1 p.m. The maximum pollen quantity was detected at 10 meters from the ground. However, the total aeropollen concentration was extremely high (&gt;130 grains/m3) at all elevated heights compared to other studies that mostly found at lower height (approximately 1–2 m above ground). The result suggested that pollen concentrations of most pollen types increased as height increased. This study also illustrated the correlation between aeropollen quantity and local meteorological factors.ConclusionThis aeropollen survey reported that pollen concentration and diversity were affected by seasonal variation, diurnal cycle, and height from the ground. Understanding these relationships can help with predictions of aeropollen type and quantity.
Extreme temperature exposure and urolithiasis: A time series analysis in Ganzhou, China
Authors: Li Zhijin , Li Yanlu , Wang Xiaoning , Liu Guoliang , Hao Yanbin 
Published: December 2022

BackgroundAmbient temperature change is a risk factor for urolithiasis that cannot be ignored. The association between temperature and urolithiasis varies from region to region. Our study aimed to analyze the impact of extremely high and low temperatures on the number of inpatients for urolithiasis and their lag effect in Ganzhou City, China.MethodsWe collected the daily number of inpatients with urolithiasis in Ganzhou from 2018 to 2019 and the meteorological data for the same period. The exposure-response relationship between the daily mean temperature and the number of inpatients with urolithiasis was studied by the distributed lag non-linear model (DLNM). The effect of extreme temperatures was also analyzed. A stratification analysis was performed for different gender and age groups.ResultsThere were 38,184 hospitalizations for urolithiasis from 2018 to 2019 in Ganzhou. The exposure-response curve between the daily mean temperature and the number of inpatients with urolithiasis in Ganzhou was non-linear and had an observed lag effect. The warm effects (30.4°C) were presented at lag 2 and lag 5–lag 9 days, and the cold effects (2.9°C) were presented at lag 8 and lag 3–lag 4 days. The maximum cumulative warm effects were at lag 0–10 days (cumulative relative risk, CRR = 2.379, 95% CI: 1.771, 3.196), and the maximum cumulative cold effects were at lag 0–5 (CRR = 1.182, 95% CI: 1.054, 1.326). Men and people between the ages of 21 and 40 were more susceptible to the extreme temperatures that cause urolithiasis.ConclusionExtreme temperature was correlated with a high risk of urolithiasis hospitalizations, and the warm effects had a longer duration than the cold effects. Preventing urolithiasis and protecting vulnerable people is critical in extreme temperature environments.
The Need to Address Fragmentation and Silos in Mortality Information Systems: The Case of Ghana and Peru
Authors: Cobos Muñoz Daniel , Sant Fruchtman Carmen , Miki Janet , Vargas-Herrera Javier , Woode Sarah , Dake Fidelia A. A. , Clapham Benjamin , De Savigny Don , Botchway Emmanuel 
Published: December 2022

Objectives: We aimed to understand the information architecture and degree of integration of mortality surveillance systems in Ghana and Peru.Methods: We conducted a cross-sectional study using a combination of document review and unstructured interviews to describe and analyse the sub-systems collecting mortality data.Results: We identified 18 and 16 information subsystems with independent databases capturing death events in Peru and Ghana respectively. The mortality information architecture was highly fragmented with a multiplicity of unconnected data silos and with formal and informal data collection systems.Conclusion: Reliable and timely information about who dies where and from what underlying cause is essential to reporting progress on Sustainable Development Goals, ensuring policies are responding to population health dynamics, and understanding the impact of threats and events like the COVID-19 pandemic. Integrating systems hosted in different parts of government remains a challenge for countries and limits the ability of statistics systems to produce accurate and timely information. Our study exposes multiple opportunities to improve the design of mortality surveillance systems by integrating existing subsystems currently operating in silos.
Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies
Authors: Susanti Laila , Mustarichie Resmi , Halimah Eli , Kurnia Dikdik , Setiawan Andi , Maladan Yustinus 
Published: December 2022

Androgenic alopecia (AA) is a condition that most commonly affects adult men and is caused by an increase in the hormone dihydrotestosterone (DHT) in the hair follicles. Anti-alopecia drugs should be discovered for hair follicles to enter the anagen growth phase. Therefore, this study evaluated the hair growth-promoting activity of Noni fruit’s water, ethyl acetate, n-hexane fractions, and sub-fractions from the active fraction in the alopecia male white rabbit model. The Matias method was modified by inducing rabbits using DHT for 17 days, followed by topical application of Noni fruit solution for 21 days. Meanwhile, hair growth was evaluated by histological observation of the follicular density and the anagen/telogen (A/T) ratio in skin tissue. In the first stage, five groups of male white rabbits were studied to obtain the active fraction; DHT+Minoxidil as standard, DHT+vehicle (NaCMC 1%), DHT+FW, DHT+FEA, and DHT+FH. The FEA as the active fraction was followed by open-column chromatography separation (DCM:Methanol) with a gradient of 10% to produce sub-fractions. In the second stage, the six main sub-fraction groups of male rabbits studied were DHT+FEA-1 to DHT+FEA-6. The follicular density of groups FEA-3 was 78.00 ± 1.52 compared with 31.55 ± 1.64 and 80.12 ± 1.02 in the Vehicle and Minoxidil groups. Additionally, group FEA-3 showed large numbers of anagen follicles with an A/T ratio of 1.64/1 compared to the vehicle group of 1/1.50 and 1.39/1 for Minoxidil control. Group FEA-3 was identified by LC-MS/MS-QTOF, followed by molecular docking to the androgen receptor (PDB: 4K7A), causing alopecia. The results showed that three alkaloid compounds with skeleton piperazine and piperidine, namely (compounds 2 (−4.99 Kcal/mol), 3 (−4.60 Kcal/mol), and 4 (−4.57 Kcal/mol)) had a binding affinity similar to Minoxidil, with also has alkaloid skeleton piperidine–pyrimidine (−4.83 Kcal/mol). The dynamic behavior showed the stability of all androgen receptor compounds with good RMSD, SMSF, and SASA values after being studied with 100 ns molecular dynamics (MD) simulations. This study produced a common thread in discovering a class of alkaloid compounds as inhibitors of androgen receptors that cause alopecia.
THE CRITICAL CONCEPT OF NORMAL PERSONALITY IN ISLAM
Authors: Hadi Abdul , Uyuni Badrah 
Published: December 2022

This study come to high light the normal personality in Islam in regarding to human nature and behaviors. human in the perception of Islam is composed of the body and spirit, and behavior. Is the outcome of the interaction of these two components, to understand that interaction and those relationships must be aware of the first part of the human, and the other part of God. Human behavior mostly belongs to two different systems, starting to work and influence since the creation of the fetus in the mother's womb, this creation has two aspects, one body and the other breathed the soul. The Islamic point of view in interpreting human behavior on several levels, each level is suitable for understanding a specific knowledge source and a specific research methodology: There is a reflexive level of behavior and could be understood by way of behavior theory. And there is a physiological level and is understood by the physiological path., and there is a social level and is understood by sociology and anthropology, and there is spiritual level and is understood by divine science (revelation).
Studi ini menyoroti kepribadian normal dalam Islam dan kaitannya dengan sifat dan perilaku manusia. Manusia dalam persepsi Islam terdiri atas badan, roh, dan tingkah laku. Apakah interaksi dan hubungan komponen-komponen tersebut harus menyadari bagian pertama dari manusia, dan bagian lain dari Tuhan. Tingkah laku manusia sebagian besar termasuk dalam dua sistem yang berbeda, mulai dari bekerja dan terpengaruh sejak lahirnya janin dari kandungan ibu, ciptaan ini memiliki dua aspek, satunya adalah jasad dan satunya lagi adalah bernafas. Sudut pandang Islam dalam memaknai tingkah laku manusia terdiri dari beberapa tingkatan, masing-masing tingkatan cukup untuk memahami sumber pengetahuan tertentu dan metodologi penelitian tertentu: Ada tingkah laku yang bersifat refleksif dan dapat dipahami melalui teori tingkah laku. Dan ada tingkat fisiologis dan dipahami oleh jalur fisiologis., Dan ada tingkat sosial dan dipahami oleh ilmu sosiologi dan ilmu antropologi, dan ada tingkat spiritual dan dipahami oleh ilmu ketuhanan (wahyu).
AL-BIIÁH FII DHAWÍL QURÁNIL KAREEM
Authors: Yasin Hadi 
Published: December 2022

المحادثات حول البيئة هي موضوع كان دائمًا موضوعًا شائعًا في وسائل الإعلام المختلفة, لأن البيئة هي إحدى القضايا العالمية التي لطالما كانت مصدر قلق للمجتمع العالمي. الإسلام كدين عالمي خالٍ من الحدود القبلية وحتى حدود الدولة ، بالطبع له قيم مهمة يجب الكشف عنها ، خاصة اهتمام القرآن بالبيئة. لهذا السبب تريد هذه الورقة الكشف عن مدى اهتمام القرآن بالمشاكل البيئية. يريد المؤلف في هذه الورقة الكشف عن كيفية كشف الله سبحانه وتعالى عن العلامات العلمية من آيات القرآن فيما يتعلق بموضوع البيئة وكيفية التعامل معها. على وجه الخصوص ، فإن العناصر الخمسة الرئيسية للبيئة ، وهي: الماء والهواء والأرض والحيوانات والأشجار ، تلخص آيات القرآن حول عناصر البيئة الخمسة ، تكملها عدة شروح وتحليلات علمية من كبار المعلقين.
Pembicaraan seputar lingkungan hidup, merupakan tema yang senantiasa menjadi trending topik di berbagai media, karena lingkungan hidup termasuk satu di antara isu-isu global yang selalu menjadi perhatian masyarakat dunia. Islam sebagai agama global yang terbebas dari skat-skat kesukuan bahkan skat-skat negara, tentu memiliki nilai-nilai yang penting untuk diungkap, khususnya perhatian Al-Quran terhadap lingkungan hidup. Itulah sebabnya makalah ini hendak mengungkap sejauh mana perhatian al-quran terhadap masalah lingkungan hidup. Pada tulisan ini penulis hendak mengungkap tentang bagaimana Allah SWT mengungkap isyarat-isyarat ilmiah dari ayat-ayat Al-Quran seputar tema lingkungan hidup, dan bagaimana memperlakukannya, khsusnya 5 unsur pokok lingkungan hidup, yaitu: air, udara, tanah, hewan, dan pepohonan, dengan merangkum ayat-ayat al-Quran seputar lima unsur lingkungan hidup tersebut, dilengkapi dengan bebepara penjelasan dan analisa ilmiah dari para mufassir terkemuka.
AL GHAZALI'S RESPONSIBILITY AND IBNU RUSYD'S DEFENSE AGAINST THREE QUESTIONS OF METAPHYSICS OF PHILOSOPHERS
Authors: Surajiyo Surajiyo 
Published: December 2022

There is a controversy between Al Ghazali and Ibn Rushd in responding to three metaphysical issues, namely the Qadim of nature, God does not know about small matters or events, Denial of bodily resurrection. On the one hand, Al Ghazali considers that the philosophers who think and believe in these three metaphysical issues are considered infidels. On the other hand, Ibn Rushd thinks that the infidel laws that have been imposed by Al Ghazali against the philosophers are not justified. This research method uses a description method, namely a literary discussion, especially literature that discusses the thoughts of Al Ghazali and Ubnu Rushd. In this method, classification, data processing and conclusions are carried out. Thus, comparative methods, analytical methods, and synthesis methods are needed.
Terdapat kontroversial antara Al Ghazali dan Ibnu Rusyd dalam menanggapi tiga persoalan metafisika yakni Qadimnya alam, Tuhan tidak mengetahui tentang soal-soal atau peristiwa-peristiwa kecil, Pengingkaran terhadap kebangkitan jasmani. Disatu pihak Al Ghazali menganggap bahwa para filosof yang berpendapat dan yang memepercayainya ketiga persoalan metafisika itu dianggap kafir. Dilain pihak Ibnu Rusyd beranggapan bahwa hukum kafir yang telah dijatuhkan oleh Al Ghazali terhadap para filosof itu tidak dibenarkan. Metode penelitian ini dengan metode deskripsi yaitu pembahasan yang bersifat literer khususnya literartur yang membahas pikiran Al Ghazali dan Ubnu Rusyd. Di dalam metode ini dilakukan klasifikasi, pengolahan data dan peyimpulan. Dengan demikian diperlukan metode komparatif, metode analisa, dan metode sintesa.