bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PIJAT ENDORPHIN TERHADAP PENURUNAN INTENSITAS NYERI PERSALINAN: LITERATURE REVIEW
Authors: Silah Naution Nur Hasilah , Destariyani Elvi , Yunita Baska Dwie 
Published: November 2022

Rasa nyeri persalinan disebabkan proses kontraksi dari Rahim dalam usaha untuk mengeluarkan buah kehamilan. Dalam persalinan, nyeri yang timbul menyebabkan stress, dan rasa khawatir berlebihan. Mengatasi rasa nyeri persalinan yaitu dengan terapi farmakologis dan non-farmakologis. Terapi non-farmakologi berupa pijat endorphin dapat menjadi salah satu pilihan dan dapat diterapkan untuk mengurangi intensitas nyeri persalinan. Tujuan penelitian ini untuk diketahui intensitas nyeri persalinan dan pengaruh pengaruh pijat endorphin terhadap penurunan intensitas nyeri persalinan dengan melakukan literature review beberapa artikel terkait. Metode yang digunakan adalah literatur review dengan desain penelitian eksperiment design. Sumber Pencarian literatur menggunakan empat database yaitu: Google Scholar, Portal Garuda, Indonesia One Search dan SINTA dengan tahun terbit 2016-2020. Seleksi studi sesuai kriteria inkulsi dengan prisma checklist dari judul, abstrak, full text dan dinilai kelayakan studi selanjutnya dianalisis dari temuan studi.Hasil pencarian terdapat 10 jurnal yang memenuhi kriteria inkulsi. Setelah ditabulasi dan dianalisis 10 studi menggunakan eksperiment design dan secara keseluruhan menunjukkan bahwa ibu bersalin mengalami nyeri persalinan dengan intensitas nyeri ringan, nyeri sedang, nyeri berat dan secara keseluruhan studi menunjukkan bahwa terapi pijat endorphin memberikan pengaruh terhadap internsitas nyeri persalinan. Kesimpulan pijat endorphin merupakan intervensi yang layak diberikan untuk penurunan intensitas nyeri persalinan.

Kata Kunci: Pengaruh, Pijat Endorphin, Nyeri, Persalinan kala I
Formulasi Jamu Instan Antidiabetes Dari Ekstrak Ethanol Biji Kebiul (Caesalphinia bonduc (L) Roxb)
Authors: Nurwani Nurwani Purnama Aji , Dharmayanti Luky , Ningsy Agustia 
Published: November 2022

Biji kebiul mengandung metabolit sekunder alkaloid, saponin, steroid, triterpenoid dan flavonoid yang secara tradisional dapat mengobati diabetes melitus. Ekstrak biji kebiul diformulasi dalam bentuk sediaan jamu instan yang diseduh dengan air matang. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol biji kebiul dapat dibuat dalam bentuk sediaan serbuk jamu instan. Ekstrak biji kebiul sebagai zat aktif dibuat dengan metode maserasi menggunakan pelarut etanol 70 % kemudiaan dibuat dalam sediaan serbuk jamu instan dengan konsentrasi ekstrak yaitu 1 %, 1,5 %, dan 2 % selanjutnya dilakukan uji sifat fisik sedian serbuk jamu instan meliputi uji organoleptis, uji waktu alir, uji pH, uji sisa pelarut, uji hedonik. Hasil uji sifat fisik uji organoleptis semua formulasi sediaan berbentuk serbuk halus, berbau khas biji kebiul, berwarna kuning kehijauan. Hasil penelitian uji waktu alir yaitu F0-F3 dengan nilai (19,72-22,88 detik) dengan sudut diam F1, F2,(35,37˚) sedangkan F0, F3 (33,82˚). Hasil uji pH selama empat minggu menunjukan pH F0-F3 nilai yaitu 4,3-4,4. Hasil uji hedonik jamu instan biji kebiul formulasi F1 lebih suka. Dapat disimpulkan bahwa ekstrak biji kebiul dapat dibuat dalam bentuk sediaan serbuk jamu instan dan dengan perbedaan konsentrasi mempengaruhi sifat fisik dari rasa.
PERBEDAAN EFEKTIVITAS REBUSAN DAUN CENGKEH (Syzygium aromaticum L) DAN DAUN PANDAN (Pandanus amaryllifolius Roxb) SEBAGAI PENGUSIR LALAT RUMAH (Musca domestica)
Authors: Pahruddin Muhammad , Aris Sandi Rigo , Zubaidah Tien 
Published: November 2022

Abstract: Flies are vectors of foodborne diseases, among others, vomiting, diarrhea, typhoid, dysentery, and myiasis. Therefore, flies need to be controlled, one of the methods to control flies is using natural pesticides. The purpose of this study was to determine the differences in the effectiveness of decoction of clove leaves (Syzygium aromaticum L) and pandan leaves (Pandanus amaryllifolius Roxb) as a vegetable repellent for house flies (Musca domestica). This type of research was true experiment with a Posttest Only Control Group Design design. The samples in this research were the house fly (Musca domestica) with the number 315 tail and repetition 3 times. The results showed that there was a difference in effectiveness between the decoction of clove (Syzygium aromaticum L) and pandan (Pandanus amaryllifolius Roxb) leaves. With the difference power repellent repellent in the two types of repellent, namely repellent the clove leaf concentration of 40% was 91.46% and repellent pandan leaf concentration of 40% was 92.36%. From the results of this study, it is advisable for the public to use a decoction of pandan leaves (Pandanus amaryllifolius Roxb) as an repellent house fly (Musca domestica) environmentally friendly and further research can be carried out on carrier insects vector other.
MODEL SISTEM PENGENDALIAN ANGKA KUMAN UDARA DI RUANGAN RAWAT INAP PUSKESMAS BETUNGAN KOTA BENGKULU
Authors: Jubaidi Jubaidi , Rahmadayani Fitri , Mualim  
Published: November 2022

Kualitas udara di dalam ruangan (indoor air) sangat mempengaruhi kesehatan kita, karena hampir 90% hidup manusia berada dalam ruangan. Sebanyak 400-500 juta orang khususnya di Negara yang sedang berhadapan dengan masalah polusi udara dalam ruangan ( Depkes RI, 2007). Tujuan umum penelitian ini adalah diketahui efektivitas model sistem pengendalian angka kuman udara di ruangan rawat inap puskesmas betungan kota bengkulu.
Metode pada penelitian ini, jenis penelitian yang digunakan adalah penelitian eksperimen semu (quasi experimental), dengan rancangan penelitian pretest-posttest (Sugiyono 2015).
Hasil pemeriksaan angka kuman udara pada Rungan rawat inap diperoleh rata-rata angka kuman uadara sebesar 128 CFU/m³. Hasil Perhitungan Model sistem pengendalian angka kuman udara dengan konsentrasi Wipol 15%, 20%, 25% rata-rata penurunan 31 CFU/m³, 37CFU/m³, 59 CFU/m³. Berdasarkan uji statistik sebelum dan sesudah disinfeksi tidak menununjukkan penurunan yang signifikan dari perlakuan menggunakan konsentrasi wipol dengan P value 0,051. Selisih angka kuman udara sebelum diberikan perlakuan dengan angka kuman udara yang sudah diberikan perlakuan adalah antara -21809 sampai 59,99587.
Saran: Menambahkan lagi dosis wipol yang digunakan sebagai disinfektan, Pemilihan metode yang berbeda dan alat sampling, Pada penelitian selanjutnya agar memperbesar kapasitas reaktor/alat dengan mengubah dimensi reaktor/alat dan menggunakan variasi kekuatan pompa udara yang lebih efektif dalam menurunkan angka kuman.
HUBUNGAN FAKTOR PERILAKU NYATA PADA PENDERITA SKABIES DENGAN KEJADIAN SKABIES DI WILAYAH KERJA PUSKESMAS RAWAT INAP CEMPAKA
Authors: Pathia Geby , Maharso  , Noraida  
Published: November 2022

Abstract: Skin diseases that often found in Indonesia is scabies, caused by infestation and sensitization of mites (Sarcoptes scabies varian hominis).This disease can be transmitted directly (skin with skin contact) and indirectly (through objects). Scabies disease data that obtained from Banjarbaru Public Health Office, in the past 3 years scabies diseases was found in Cempaka Inpatient Community Health Center. The purpose of this research is to know the relation of real behavior factors taking a bath habit, the habit of using soap, changing clothes habits, and the habit of using towel simultaneously) with the case of scabies in Cempaka Inpatient Community Health Center Domain. This research type is an observational in the form of analytic, this research using case control study, which is comparing the behavior between case group with control group related to the scabies incident .The results of this study showed that there was a relation between taking a bath habit with the occurrence of scabies (p-value = 0,018 <value α = 0.05), there was a relation between the habit of using soap with the occurrence of scabies (p-value = 0,026 <value α = 0.05) , There is no relation of change clothing with the occurrence of scabies (p-value = 1,000>value α = 0,05), there is no relationof using towel simultaneously with scabies occurrence (p-value = 0,653>value α = 0,05).

Abstrak: Penyakit kulit yang sering dijumpai di Indonesia adalah skabies, disebabkan oleh infestasi dan sensitisasi terhadap tungau (Sarcoptes scabies varian hominis). Penyakit ini ditularkan secara langsung (kontak kulit dengan kulit dan secara tidak langsung melalui benda) misalnya pakaian, handuk, dan bantal. Data penyakit skabies di dapat dari Dinas Kesehatan Kota Banjarbaru, penyakit skabies 3 tahun terakhir terdapat di Puskesmas Rawat Inap Cempaka. Tujuan pada penelitian ini untuk mengetahui hubungan faktor perilaku nyata kebiasaan mandi, kebiasaan menggunakan sabun, kebiasaan ganti pakaian, dan kebiasaan menggunakan handuk secara bersamaan) dengan kejadian skabies di Wilayah Kerja Puskesmas Rawat Inap Cempaka. Jenis penelitian ini observasional dalam bentuk analitik, desain penelitian ini menggunakan case control study. Hasil penelitian ini menunjukkan ada hubungan antara kebiasaan mandi dengan kejadian skabies (p-value=0,018 < nilai α = 0,05), ada hubungan antara kebiasaan menggunakan sabun dengan kejadian skabies (p-value=0,026 < nilai α = 0,05), tidak ada hubungan kebiasaan menggunakan pakaian dengan kejadian skabies (nilai p-value=1,000 >nilai α=0,05), tidak ada hubungan kebiasaan menggunakan handuk dengan kejadian skabies (p-value=0,653 > nilai α = 0,05).
Melioidosis: A Case Report of Confirmed Burkholderia Pseudomallei in Rangpur Medical College Hospital, Rangpur
Authors: Miah Md Helal , Begum Tania , Alam Md Shafiul , Mondol ASM Rahenur , Ul Anwar Md Mahfuj 
Published: November 2022

Bangladesh is an example of a highly populous, agricultural country where melioidosis may be a significantly underdiagnosed cause of infection and death. Melioidosis is caused by a highly pathogenic, soil-borne, Gram-negative bacterium, Burkholderia pseudomallei. Diabetes mellitus is the most common risk factor. Disease manifestations vary from pneumonia or localized abscess to acute septicemia or arthritis. Culture is considered the current gold- standard for diagnosis. For the intensive phase (10 to 14 days), ceftazidime or meropenem is the drug of choice. For the eradication phase (3 to 6 months), oral trimethoprim/ sulfamethoxazole is the drug of choice. Surgery (drainage of abscess) has an important role in the management of melioidosis. A 48-year-old male, health worker of an NGO, working at Cox’s Bazar presented with fever for 1 month and gradual increasing pain and swelling of the left knee for 7 days followed by cellulitis and multiple abscess formation in the left leg. B. pseudomallei isolated from blood culture and successfully treated with meropenem.
J Rang Med Col. September 2022; Vol. 7, No. 2:69-72
Multi-planar instability, laxity and reduced knee flexion during the support phase of walking are determinants of return to sports
Authors: Zhou Tianping , Xu Yihong , Zhou Lan , Wang Siya , Wang Shaobai , Xu Weidong 
Published: November 2022

Background: After anterior cruciate ligament reconstruction, some patients are not recommended to return to high-level physical activity because they fail to pass return-to-sports tests. The kinematic difference between these patients and those who pass the return-to-sports tests is unclear.Methods: Eighty-two patients who received anatomic single-bundle anterior cruciate ligament (ACL) reconstruction for unilateral ACL injury underwent return-to-sport tests during a hospital visit at a minimum of 9 months (9–11 months) of follow-up. Fifteen patients who passed the return-to-sports tests (RTS group) and fifteen patients who did not (NRTS group) were randomly selected to perform a treadmill walk under dual-fluoroscopic imaging system surveillance for a 6 degrees of freedom kinematic evaluation.Results: Of the 82 patients, 53 passed the return-to-sports tests 9 months after surgery, with a return-to-sports rate of 64.6%. In the stance phase, the NRTS group had a larger anterior tibial translation (1.00 ± 0.03 mm vs. 0.76 ± 0.03 mm, p = 0.001), a larger lateral tibial movement (1.61 ± 0.05 mm vs. 0.77 ± 0.05 mm, p &lt; 0.001), a larger distal tibial displacement (−3.09 ± 0.05 mm vs. −2.69 ± 0.05 mm, p &lt; 0.001), a smaller knee flexion angle (6.72 ± 0.07° vs. 8.34 ± 0.07°, p &lt; 0.001), a larger varus angle (−0.40 ± 0.03°VS. -0.01 ± 0.03°, p &lt; 0.001) and a larger external rotation angle (1.80 ± 0.05° vs. 1.77 ± 0.05°, p &lt; 0.001) than the RTS group. The maximum anterior tibial translation of the NRTS group is also larger than that of the RTS group (3.64 ± 0.42 mm vs. 3.03 ± 0.59 mm, p = 0.003).Conclusion: Compared with patients passing RTS tests, those who fail to pass show significant anterior, lateral, and rotational instability; knee laxity; and reduced flexion angle of the knee in the support phase during walking, which may be the possible factors hindering a return to sports.
Synthesis, characterization, and biological activities of zinc(II), copper(II) and nickel(II) complexes of an aminoquinoline derivative
Authors: Damena Tadewos , Alem Mamaru Bitew , Zeleke Digafie , Desalegn Tegene , Eswaramoorthy Rajalakshmanan , Demissie Taye B. 
Published: November 2022

Interest is increasingly focused on the use of transition metal complexes as biochemical, medical, analytical, pharmaceutical, agronomic, anticancer, and antibacterial agents. In this study, three complexes of [Zn(H2L)Cl] (1), [Cu(H2L)(H2O)(NO3)] (2) and [Ni(H2L)(NO3)].2H2O (3) were synthesized from a 2-chloroquinoline-3-carbaldehyde derived ligand [H3L = ((E)-2-(((2-((2-hydroxyethyl)amino)quinolin-3-yl)methylene)amino)ethanol. The compounds were characterized using physicochemical and spectroscopic methods. The results demonstrate that the free ligand behaves as a tridentate ligand with one oxygen and two nitrogen (ONN) donor atoms in 1:1 metal:ligand ratio. The formation constants of the complexes were found to be (KZn(II) = 2.3 × 106, KCu(II) = 2.9 × 106, and KNi(II) = 3.8 × 105). The thermodynamic parameters indicated that the reactions were spontaneous with exothermic nature of metal-ligand interaction energies. Based on the analyses of the experimental (EDX, FTIR, PXRD, MS and TGA) and DFT results, a distorted tetrahedral, a distorted square pyramidal and square planar geometry for Zn(II), Cu(II) and Ni(II) complexes, respectively, were proposed. The B3LYP calculated IR frequencies and TD-B3LYP calculated absorption spectra were found to be in good agreement with the corresponding experimental results. The powder XRD data confirmed that the Zn(II), Cu(II) and Ni(II) complexes have polycrystalline nature with average crystallite sizes of 27.86, 33.54, 37.40 Å, respectively. In vitro antibacterial activity analyses of the complexes were studied with disk diffusion method, in which the complexes showed better activity than the precursor ligand. Particularly the Cu(II) complex showed higher percent activity index (62, 90%), than both Zn(II) (54, 82%) and Ni(II) (41, 68%) complexes against both E. coli and P. aeruginosa, respectively. Using the DPPH assay, the complexes were further assessed for their antioxidant capacities. All metal complexes showed improved antioxidant activity than the free ligand. Zn(II) and Cu(II) complexes, which had IC50 values of 10.46 and 8.62 μg/ml, respectively, showed the best antioxidant activity. The calculated results of Lipinski’s rule of five also showed that the target complexes have drug-like molecular nature and similarly, the results of binding mode of action of these compounds against E. coli DNA gyrase B and P. aeruginosa LasR.DNA were found to be in good agreement with the in vitro biological activities.
Persistence with daily growth hormone among children and adolescents with growth hormone deficiency in the UK
Authors: Loftus Jane , Wogen Jen , Oliveri David , Benjumea Darrin , Jhingran Priti , Chen Yong , Alvir Jose , Rivero-Sanz Elena , Kowalik Jack C. , Wajnrajch Michael P. 
Published: November 2022

BackgroundChildren with growth hormone deficiency (GHD) are treated with daily somatropin injections; however, poor treatment persistence and adherence have been recognized previously and have been shown to negatively impact growth outcomes. A recent real-world study of a US pediatric GHD population found that a substantial proportion of children discontinued somatropin therapy, but similar data for a real-world UK population are lacking.ObjectivesTo describe the discontinuation of, and persistence with, daily somatropin treatment among children with GHD in the UK.MethodsThis was a retrospective cohort study of children (≥3 and &lt;16 years old) with ≥1 medication prescription for daily injectable somatropin from 1 July 2000 to 31 December 2020 in the IQVIA Medical Research DATA (IMRD) database. Early persistence was defined as the proportion of children prescribed ≥1 somatropin refill (≥2 prescriptions). Discontinuation was defined as the first date at which a medication gap for somatropin (of &gt;60 or &gt;90 days between prescriptions) occurred. Kaplan–Meier methods were used to evaluate persistence (non-discontinuation) over time to assess time to first discontinuation event. Cox proportional hazards models were used to evaluate the relationship between patient characteristics and time to medication discontinuation.ResultsAmong the cohort identified in this study (n = 117), the majority (n = 84, 71.8%) had 48 months of available follow-up; 56.4% were boys and the mean (median) age was 8.6 (8.0) years. About 98% exhibited early persistence, but persistence over the follow-up period decreased with follow-up duration. Using the conservative 90-day gap definition of persistence, an estimated 72.4%, 52.8%, and 43.3% were persistent at 12, 36, and 48 months. Lower persistence rates were observed using the 60-day definition. No significant patient predictors of time to discontinuation were identified.ConclusionsDespite high early persistence with somatropin, a high percentage of children with GHD were increasingly non-persistent over time. More than 1 in 4 were non-persistent at 12 months and more than 1 in 2 were non-persistent at 48 months of follow-up. These results suggest that strategies to support improved medication-taking behavior among children with GHD in the UK are warranted.
Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats
Authors: Ding Huanxin , Liu Chuxuan , Zhang Shuo , Li Bingjun , Xu Qian , Shi Bowen , Li Songhan , Dong Shuohui , Ma Xiaomin , Zhang Yun , Zhong Mingwei , Zhang Guangyong 
Published: November 2022

ObjectiveTo investigate the effects of sleeve gastrectomy (SG) on diabetes-related cognitive decline (DCD) in rats with diabetic mellitus (DM).Methods and methodsForty Wistar rats were randomly divided into control (CON) group (n=10), diabetes mellitus (DM) group (n=10), sham operation (SHAM) group (n=10) and SG group (n=10). DM model was established by high-fat diet (HFD) combined with intraperitoneal injection of streptozocin (STZ). Behavioral evaluation was given using Morris water maze test and Y-maze. In addition, PET-CT, TUNEL assay, histological analysis, transmission electron microscopy (TEM), immunohistochemistry (IHC) and Western blot analysis were used to evaluate the alleviating effects and potential mechanisms of SG on DCD in DM rats.ResultsCompared with the sham group, SG induced significant improvement in the metabolic indices such as blood glucose and body weight. Besides, it could attenuate the insulin resistance compared with SHAM group. In addition, SG could improve the cognitive function of DM rats, which were featured by significant decrease in the escape latency (P&lt;0.05), and significant increase in the time in target quadrant and platform crossings (P&lt;0.05) compared with the SHAM group. SG induced significant elevation in the spontaneous alternation compared with SHAM group (P&lt;0.05). Moreover, SG could improve the arrangement and biosynthesis of hippocampus neuron. Moreover, SG triggered the inhibition of apoptosis of hippocampus neurons, and Western blot analysis showed SG induced significant increase in the ratios of Bcl-2/Bax and Caspase3/cleaved Caspase 3. TEM demonstrated SG could significantly improve the microstructure of hippocampus neurons compared with the SHAM group. Western blot and IHC confirmed the significant decrease in the phosphorylation of tau at Ser404 and Ser396 sites in the SG group. Furthermore, SG activated the PI3K signaling pathway by elevating the phosphorylation of PI3K and Akt and GSK3β compared with the SHAM group.ConclusionSG attenuated the DCD in DM rats, which may be related to the activation of PI3K signaling pathway.
Study on coupling coordination and collaborative optimization system of water-energy-grain
Authors: Ren XuYan , Ren YongTai , Pei Wei 
Published: November 2022

In order to solve the problem that water resources in a certain province are relatively scarce and the spatial matching effect of resources is poor, which causes the w-e-f system to face the problem of trade-off, the water-energy-food coupling coordination and collaborative optimization system is proposed. By constructing the w-e-f multi-objective collaborative optimization model, the multi-objective optimization schemes under different weight scenarios are compared, and scenario 2 with better effect is selected as the best scheme for collaborative optimization. The results show that, on the basis of meeting the constraint conditions, by adjusting the crop planting structure and making efficient use of resource elements, the water resource consumption of major grain crops can be reduced by 7.3% and the total energy consumption can be reduced by 2.5% by 2030 compared with 2019.ConclusionThe system provides solutions to alleviate the pressure on water resources and ecological environment to a certain extent. Compared with the single objective optimization scheme, multi-objective optimization can effectively alleviate the trade-off conflict between w-e-f.
Physical, language, neurodevelopment and phenotype-genotype correlation of Chinese patients with Mowat-Wilson syndrome
Authors: Wu Lihua , Wang Jianhong , Wang Lei , Xu Qi , Zhou Bo , Zhang Zhen , Li Qi , Wang Hui , Han Lu , Jiang Qian , Wang Lin 
Published: November 2022

Background: To report detailed knowledge about the clinical manifestations, genetic spectrum as well as physical, language, neurodevelopment features and genotype-phenotype correlations of Chinese patients with Mowat-Wilson syndrome (MWS).Methods: We retrospectively collected and analyzed clinical data for twenty-two patients with molecularly confirmed diagnoses. We used Gesell Developmental Schedules (GDS) to assess their neurodevelopment and the Diagnostic Receptive and Expressive Assessment of Mandarin-Infant &amp; Toddler (DREAM-IT) to evaluate their language ability and compared the data with the two types of underlying pathogenic variations.Results: The height and weight of all patients were below the 75th percentile, and microcephaly was observed in 16 of 22 patients (72.7%). Four patients carrying chromosome deletions encompassing the ZEB2 gene were more severely affected. All MWS patients exhibited better performance in cognitive play and social communication than in receptive and expressive language. In the receptive language area, the types of words that children with MWS understood most were nouns, followed by adjectives and verbs.Conclusion: This study delineated the phenotypic spectrum of the largest MWS cohort in China and provided comprehensive profiling of their physical, language, neurodevelopment features and genotype-phenotype correlations.