bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between tooth loss and hypertension: a systematic review and meta-analysis
Authors: Tada Akio , Tano Rumi , Miura Hiroko 
Published: August 2022

AbstractAs tooth loss is the high end of periodontal problems and edentulous individuals are at higher risk of nutritional problems like obesity, understanding the association between tooth loss and hypertension is important for improving cardiovascular health. We searched for publications from the last two decades using three electronic databases (PubMed, Web of Science and Scopus) and conducted a systematic review and meta-analysis on the association between tooth loss and hypertension according to PRISMA-P guidelines. Quality assessments were performed using the Newcastle–Ottawa Scale and the GRADE approach. Twenty-four studies (20 cross-sectional, and 4 cohort) met the inclusion criteria for this review. Most cross-sectional studies showed that subjects with more tooth loss exhibited a greater proportion of hypertension and higher systolic blood pressure than those with less tooth loss. Meta-analyses revealed a statistically significant association between tooth loss and hypertension. The pooled odds ratios of hypertension for having tooth loss with no tooth loss and for edentulous with dentate were 2.22 (95% CI 2.00–2.45) and 4.94 (95% CI 4.04–6.05), respectively. In cohort studies, subjects with more tooth loss had a greater incidence of hypertension than those with less tooth loss during the follow-up period. The present systematic review and meta-analysis suggests that tooth loss is associated with an increased risk of hypertension and higher systolic blood pressure.
Obstructive sleep apnea, chronic obstructive pulmonary disease and hypertensive microvascular disease: a cross-sectional observational cohort study
Authors: Chew Sky , Colville Deb , Hutchinson Anastasia , Canty Piers , Hodgson Lauren , Savige Judy 
Published: August 2022

AbstractHypertensive microvascular disease is associated with an increased risk of diastolic heart failure, vascular dementia and progressive renal impairment. This study examined whether individuals with obstructive sleep apnoea (OSA) had more retinal hypertensive microvascular disease than those with chronic obstructive pulmonary disease (COPD) and hospital controls. This was a single-centre, cross-sectional, observational study of participants recruited consecutively from a general respiratory clinic and a general medical clinic. OSA was diagnosed on overnight polysomnography study (apnoea:hypopnoea index ≥ 5), and controls with COPD had a forced expiratory volume/forced vital capacity (forced expiratory ratio) < 70%. Individuals with both OSA and COPD were excluded. Hospital controls had no COPD on respiratory function testing and no OSA on specialist physician questioning. Study participants completed a medical questionnaire, and underwent resting BP measurement, and retinal photography with a non-mydriatic camera. Images were deidentified and graded for microvascular retinopathy (Wong and Mitchell classification), and arteriole and venular calibre using a semiautomated method at a grading centre. Individuals with OSA (n = 79) demonstrated a trend to a higher mean arterial pressure than other hospital patients (n = 143) (89.2 ± 8.9 mmHg, p = 0.02), and more microvascular retinopathy (p < 0.001), and narrower retinal arterioles (134.2 ± 15.9 μm and 148.0 ± 16.2 μm respectively, p < 0.01). Microvascular retinopathy and arteriolar narrowing were still more common in OSA than hospital controls, after adjusting for age, BMI, mean arterial pressure, smoking history and dyslipidaemia (p < 0.01, p < 0.01, respectively). Individuals with OSA demonstrated a trend to a higher mean arterial pressure than those with COPD (n = 132, 93.2 ± 12.2 mmHg and 89.7 ± 12.8 mmHg respectively, p = 0.07), and more microvascular retinopathy (p = 0.0001) and narrower arterioles (134.2 ± 15.9 and 152.3 ± 16.8, p < 0.01). Individuals with OSA alone had more systemic microvascular disease than those with COPD alone or other hospital patients without OSA and COPD, despite being younger in age.
Classical harmonic three-body system: an experimental electronic realization
Authors: Escobar-Ruiz A. M. , Quiroz-Juarez M. A. , Del Rio-Correa J. L. , Aquino N. 
Published: August 2022

AbstractThe classical three-body harmonic system in $${\mathbb {R}}^d$$

R

d

($$d>1$$

d
>
1

) with finite rest lengths and zero total angular momentum $$L=0$$

L
=
0

is considered. This model describes the dynamics of the $$L=0$$

L
=
0

near-equilibrium configurations of three point masses $$(m_1,m_2,m_3)$$

(

m
1

,

m
2

,

m
3

)

with arbitrary pairwise potential $$V(r_{ij})$$

V
(

r

ij

)

that solely depends on the relative distances between bodies. It exhibits an interesting mixed regular and chaotic dynamics as a function of the energy and the system parameters. The corresponding harmonic quantum system plays a fundamental role in atomic and molecular physics. In this work we report on a novel electronic experimental realization of the model as a complementary tool to analyze the rich dynamics of the classical system. Our setup allows us to experimentally explore different regions of behavior due to the fact that the intrinsic parameters and initial states of the system are independently set by voltage inputs. Chaotic and periodic motions are characterized employing time series, phase planes, and the largest Lyapunov exponents as a function of the energy and system parameters. The results show an excellent qualitative as well as quantitative agreement between theory and experiment.
Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression
Authors: Watanabe Yukari , Fukuda Takao , Hayashi Chikako , Nakao Yuki , Toyoda Masaaki , Kawakami Kentaro , Shinjo Takanori , Iwashita Misaki , Yamato Hiroaki , Yotsumoto Karen , Taketomi Takaharu , Uchiumi Takeshi , Sanui Terukazu , Nishimura Fusanori 
Published: August 2022

AbstractImmunoregulatory properties of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique immunoregulatory capacity and secrete large amounts of EVs. Recent findings suggest that priming MSCs with inflammatory stimuli is an effective strategy for cell-free therapy. However, the precise mechanism by which the contents of EVs are customized has not been fully elucidated. Here, we show that EVs derived from GMSCs primed with a combination of two pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interferon-α (IFN-α), synergistically promote anti-inflammatory M2 macrophage polarization by increasing the expression of cluster of differentiation 73 (CD73) and CD5 molecule-like (CD5L). Expression of CD73 by TNF-α/IFN-α stimulation was transcriptionally upregulated by the activation of mammalian target of rapamycin signaling and nuclear translocation of hypoxia-inducible factor 1α in GMSCs. TNF-α/IFN-α treatment also significantly increased the expression of CD5L mRNA via the transcription factor DNA-binding protein inhibitor ID3 and liver X receptor. Interestingly, exosomal CD5L is a prerequisite for the synergistic effect of EVs-mediated M2 macrophage polarization. These results indicate that combined pre-licensing with TNF-α and IFN-α in GMSCs is ideal for enhancing the anti-inflammatory function of EVs, which contributes to the establishment of a therapeutic tool.
Multiple Mechanisms of Word Learning in Late-Talking Children: A Longitudinal Study
Authors: Cheung Rachael W. , Hartley Calum , Monaghan Padraic 
Published: August 2022

Purpose:
The aim of this study was to identify variability in word-learning mechanisms used by late-talking children using a longitudinal study design, which may explain variability in late-talking children's outcomes.

Method:

A cohort of typically developing children (
n
= 40) and children who were classified as late-talking children at age 2;0 (years;months; ≤ 10th percentile on expressive vocabulary,
n
= 21) were followed up at ages 3;0 and 3;6. We tested the cohort across tasks designed to isolate different mechanisms involved in word learning: encoding and producing spoken forms of words (using a nonword repetition task), identifying referents for words (using a fast mapping task), and learning associations between words and referents (using a cross-situational word-learning task).

Results:
Late-talking children had lower accuracy on nonword repetition than typically developing children, despite most of the sample reaching typical ranges for expressive vocabulary at age 3;6. There were no between-groups differences in fast mapping and retention accuracy; however, both were predicted by concurrent expressive vocabulary. Late-talking children performed less accurately than typically developing children on cross-situational word-learning retention trials, despite showing no between-groups differences during training trials. Combining performance across all three tasks predicted approximately 45% of the variance in vocabulary outcomes at the last time point.

Conclusions:
Late-talking children continue to have deficits in phonological representation that impact their word-learning ability and expressive language abilities but do not show difficulties in fast mapping novel words. Late-talking children may also struggle to retain associative information about word–referent mappings. Late-talking children thus use some, but not all, word-learning mechanisms differently than typically developing children.

Supplemental Material:

https://doi.org/10.23641/asha.20405856
Pilot Study of Respiratory–Swallow Coordination in Amyotrophic Lateral Sclerosis
Authors: Garand Kendrea L. (Focht) , Bhutada Ankita M. , Hopkins-Rossabi Theresa , Mulekar Madhuri S. , Carnaby Giselle 
Published: August 2022

Purpose:Amyotrophic lateral sclerosis (ALS) impacts bulbar and respiratory musculature, which may contribute to impaired swallow function (dysphagia) and respiratory–swallow coordination. The purpose of this pilot study was to examine if respiratory–swallow coordination in individuals with ALS was perturbed compared to healthy controls. We further explored relationships between measures of respiratory function and self-reported swallowing outcomes on respiratory–swallow coordination.Method:We employed a cross-sectional design with eight participants with ALS and eight age- and sex-matched healthy participants. Respiratory inductance plethysmography and a nasal cannula were used to capture respiratory–swallow phase patterns during a standardized clinical swallow examination. The advantageous respiratory–swallow phase pattern was defined if exhalation surrounded the swallow (E–E). Spirometry was used to capture indices of respiratory function (forced vital capacity % predicted, peak cough flow [PCF]). Validated questionnaires were used to collect information regarding ALS-related bulbar functional status and swallowing-related concerns.Results:Compared to the matched healthy cohort, individuals with ALS demonstrated higher rates of non–E-E respiratory–swallow phase patterning and worse bulbar/swallow dysfunction. Group (ALS), swallow tasks, and PCF were significantly associated with respiratory–swallow phase pattern.Conclusions:These preliminary findings support altered respiratory–swallow phase patterning in ALS. Future work should employ an instrumental assessment to quantify swallowing physiology and elucidate the relationship between perturbed respiratory–swallow coordination and swallowing function.
Distributed robust cooperative tracking against multiple maneuvering targets based on random finite set
Authors: Zhang Zheng , Dong Xiwang , Li Qingdong , Ren Zhang 
Published: August 2022

AbstractThis paper considers the distributed multi‐target tracking problem with mobile sensor network. Based on the random finite set and consensus methods, a distributed multi‐target tracking algorithm is designed by local filtering stage and consensus fusion stage. In the local filtering stage, the state and measurement information of multi‐target are described by random finite set. Each node in the sensor network obtains the state estimates of multi‐target individually by applying the probability hypothesis density filtering algorithm. To reduce the computational complexity, the Jacobian matrix and Hessian matrix are used to calculate the priori probability density. With the local neighboring interactions, the estimate results of multi‐target system are obtained after the consensus fusion stage. Besides, the stochastic boundedness of the estimation error of the distributed multi‐target tracking algorithm is proved by constructing a stochastic process. In the final, a simulation example is given to verify the multi‐target tracking performance of the proposed algorithm.
Design of ± 535 kV hybrid high voltage direct current (HVDC) circuit breaker
Authors: Liu Chenyang , Yao Weizheng , Xiang Chuan , Cheng Xufeng , Wang Qinglong 
Published: August 2022

AbstractThis paper proposes a ± 535 kV hybrid high voltage direct current (HVDC) circuit breaker. In this paper, the interruption processes of the main branch, transferring branch, and MOV (metal oxide varistors) branch are studied by PSCAD/EMTDC computer simulation. Simulation results indicate that an insulated gate bipolar transistor (IGBT) in the main branch will withstand the highest electrical stress (3305 V/2200 A) and the IGBT in the transferring branch will withstand the highest voltage stress (3327 V). Finally, the ± 535 kV hybrid HVDC circuit breaker prototype is manufactured; the test is carried out. Test results suggest that the ± 535 kV hybrid HVDC circuit breaker prototype developed for the Zhangbei four‐terminal voltage source converter (VSC)‐HVDC project can interrupt a ± 25 kA (high current) within 2.84 ms. The simulation results agreed very well with the actual test results of our novel ± 535 kV hybrid HVDC circuit breaker. The novel ± 535 kV hybrid HVDC circuit breaker functioned exceptionally well in achieving fast short‐circuit current isolation.
ImDeeplabV3plus with instance selective whitening loss in domain generalization semantic segmentation
Authors: Zhang You , Chen Houjin , Li Yanfeng , Zhou Junqi 
Published: August 2022

AbstractSemantic segmentation is a classical problem in computer vision, which is important in the field of autonomous driving. Although significant progress has been achieved in semantic segmentation, its generalization ability to unknown domains is still challenging. To effectively solve this problem, a semantic segmentation method ImDeeplabV3plus with instance selective whitening loss is proposed in this paper. DeeplabV3plus is selected as the baseline. In order to enhance the representation of the region of interest, the coordinate attention (CA) mechanism is added. To better integrate multiple low‐level features, the adaptively spatial feature fusion (ASFF) is employed to adaptively learn the importance of features at different levels for each location. For preferably coping with the domain changes, an instance selective whitening (ISW) loss is introduced in the early stage of the backbone. The model is trained with the Cityscapes dataset and then applied to the unknown domain RobotCar dataset. Compared with DeeplabV3plus, the authors’ ImDeeplabV3plus model shows 1.29% mIoU improvement. When ISW loss is added, 2.08% improvement in mIoU is achieved compared with ImDeeplabV3plus. Experimental results show that the proposed method is simple and improves the domain generalization ability.
Effect of Galactic aberration on Earth orientation parameters: From the ICRF2 to the ICRF3
Authors: Yao J. , Liu J.-C. , Liu N. , Malkin Z. , Zhu Z. , Huda I. Nural , Lambert S. B. 
Published: August 2022

Aims. At the beginning of 2019 the third realization of the International Celestial Reference Frame (ICRF3) replaced the previous version (ICRF2). In the current International Celestial Reference Frame (ICRF), a major improvement is the inclusion of the Galactic aberration (GA) effect. The Earth orientation parameters (EOP), which link the celestial and terrestrial reference frames, are thus accordingly affected. This paper investigates the influence of the ICRF evolution and the modeling of the GA effect on the determination of the EOP.
Methods. The EOP time series derived within the frame of two official ICRF realizations, as well as different ways of handling the GA effect, were estimated based on the very long baseline interferometry (VLBI) observational data obtained over the past 40 yr. The correlation between the station network and the GA contribution to the EOP was then analyzed by comparison of IVS R1 and R4 routine observations, which have a different distribution of antennas. We also studied the effect of GA on nutation and free core nutation amplitudes by least-squares fits.
Results. The application of different reference frames (ICRF2 and ICRF3) in VLBI solutions leads to constant offsets of 315 microarcsec in the components of dX, dY, and dUT 1. This difference is mainly the reflection of the orientation offsets between the two realizations of the International Celestial Reference System. In a separate study of the GA effect, an approximate 0.3 ± 0.3 uas yr−1 bias is found in dY, while other components are not significantly affected. This bias results in an increasing offset in precession which is non-negligible after several tens of years. We further found that the bias caused by the GA effect will decrease when using a set of more uniformly distributed sources or stations in the most recent decades.
Ödipus, ein traumatologisch - orthopädischer Fall?
Authors: Schwarz Markus L. R. 
Published: August 2022

ZusammenfassungDas Essay deutet die Gestalt des Ödipus und sein Schicksal nach modernen medizinisch-wissenschaftlichen Kriterien. Die Misshandlungen, die das Kleinkind erlitt, bekommen dabei als
auslösender Faktor einen besonders Stellenwert. Der Name „Ödipus“, üblicherweise mit „Schwellfuß“ übersetzt, wird hinsichtlich seines etymologischen Ursprungs untersucht, sodass verschiedene
Schlüsse aus dem Namen gezogen werden können, auch die, dass es dem Heroen leicht gefallen sein muss, das Rätsel der Sphinx zu lösen, da es mit der Funktion der Füße eine orthopädische
Kernaussage hatte. Es können bei Ödipus mehrere Verletzungen und Störungen diagnostiziert und nach dem aktuellen ICD-Schlüssel klassifiziert werden, z. B. die Blindheit, nachdem er sich
selbst geblendet hatte. Zudem ergibt sich der Verdacht auf das Vorliegen einer posttraumatischen Belastungsstörung sowie einer Borderline-Persönlichkeitsstörung, die sich einstellten,
nachdem Ödipus von seinen Eltern misshandelt wurde, um ihn zu töten. Damit wird auch die Frage nach seiner Schuld an den von ihm begangenen Taten neu hinterfragt. Die Geschichte des „Ödipus“
bestätigt die Lebenswirklichkeit griechischer Mythologie aufs Neue.
Ernährung und Bewegung – Das Konzept der Prähabilitation vor großen Tumoroperationen
Authors: Oberhoffner Christin , Fischer Martin , Wobith Maria , Weimann Arved 
Published: August 2022

Zusammenfassung
Einleitung Mit dem Ziel des Enhanced Recovery After Surgery (ERAS) gewinnt bei Risikopatienten die präoperative Phase zur optimalen Konditionierung an Bedeutung, um damit auch das Risiko von postoperativen Komplikationen zu vermindern. Prähabilitation als multimodales Modell bestehend aus Ernährungstherapie, Kraft- und Ausdauertraining, sowie psychologischer Unterstützung soll es ermöglichen, dass Patienten selbstständig daran mitwirken können, bestmöglich für eine Operation vorbereitet zu sein und sich schneller von den eventuell auftretenden Nachwirkungen zu erholen. Ein optimierter Ernährungszustand und eine Verbesserung der Belastbarkeit bilden dabei die Basis, um ein individuell an den Patienten angepasstes Programm zu erstellen.
Methoden Das circa 6-wöchige Prähabilitationsprogramm für Patienten besteht aus Mobilitäts- und Kraftübungen, Hausbesuchen, einer Ernährungstherapie und psychologischer Unterstützung. Eingeschlossen werden Hoch-Risiko-Patienten vor großen abdominalchirurgischen Tumoroperationen, die mindestens 70 Jahre alt sind, einen ASA-Score von 3 oder 4 haben und bei denen die Indikationen für eine neoadjuvante Therapie besteht. Ausgewertet werden Ernährungsstatus, Tests zur funktionellen Belastbarkeit, dem kognitiven Zustand und ein Fragebogen zur Beurteilung der Lebensqualität zu Beginn, mehrfach während des Programms und postoperativ.
Schlussfolgerung Durch die intensive und engmaschige Betreuung, sowie der Chance, dass Patienten selber etwas aktiv beisteuern können, besteht die Möglichkeit die besten Voraussetzungen zu schaffen, um Einfluss auf das Outcome der Operation zu erlangen. Eine Senkung der Komplikationsrate, eine Verkürzung der Krankenhausverweildauer und ein schnelleres Zurückerlangen der Mobilität stehen dabei im Vordergrund.
Development of alimentary tract organs for ICRP pediatric mesh-type reference computational phantoms
Authors: Choi Chansoo , Shin Bangho , Yeom Yeon Soo , Nguyen Thang Tat , Han Haegin , Kim Suhyeon , Son Gahee , Moon Sungho , Kim Hyeonil , Kim Chan Hyeong , Bolch Wesley E , Jokisch Derek W , Lee Choonsik , Chung Beom Sun 
Published: August 2022

AbstractIn line with the activities of Task Group 103 under the International Commission on Radiological Protection (ICRP), the present study was conducted to develop a new set of alimentary tract organs consisting of the oral cavity, oesophagus, stomach, small intestine, and colon for the newborn, 1 year-old, 5 year-old, 10 year-old, and 15 year-old males and females for use in the pediatric mesh-type reference computational phantoms (MRCPs). The developed alimentary tract organs of the pediatric MRCPs, while nearly preserving the original topology and shape of those of the pediatric voxel-type reference computational phantoms (VRCPs) of ICRPPublication 143, present considerable anatomical improvement and include all micrometre-scale target and source regions as prescribed in ICRPPublication 100. To investigate the dosimetric impact of the developed alimentary tract organs, organ doses and specific absorbed fractions were computed for certain external exposures to photons and electrons and internal exposures to electrons, respectively, which were then compared with the values computed using the current ICRP models (i.e. pediatric VRCPs and ICRP-100 stylised models). The results showed that for external exposures to penetrating radiations (i.e. photons >0.04 MeV), there was generally good agreement between the compared values, within a 10% difference, except for the oral mucosa. For external exposures to weakly penetrating radiations (i.e. low-energy photons and electrons), there were significant differences, up to a factor of ∼8300, owing to the geometric difference caused by the anatomical enhancement in the MRCPs. For internal exposures of electrons, there were significant differences, the maximum of which reached a factor of ∼73 000. This was attributed not only to the geometric difference but also to the target mass difference caused by the different luminal content mass and organ shape.