bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lucius Polk Brown and Progressive Food and Drug Control
Authors: Wolfe Margaret Ripley 
Published: April 2022

Lucius Polk Brown was a professional chemist who became a bureaucrat in the field of public health during the Progressive era, when middle-class reformers first attempted to order American society through integrated systems. In his native state of Tennessee, between 1908 and 1915 Brown created a public health enforcement agency, began educating the masses to public health needs, waged flamboyant campaigns against those who violated the laws, and attracted widespread support for pure food and drug control. Moving on to become director of the Bureau of Food and Drugs in the New York City Department of Health in 1915, he continued his battle for public health reform amidst the maze of government agencies and political power struggles surrounding Tammany Hall.In Many respects Brown was typical of Progressive reformers. A middle-class, Anglo-Saxon Protestant and a professional, he represented a link between the nineteenth-century agrarian and the twentieth-century urbanite. More importantly, Brown exemplified a new character on the American scene: a scientist out of the agricultural-experiment-station mold entering public life, ready to challenge politicians on their own ground.This book contains fresh insights on the history of the public health movement in America, one area of reform that has not received the attention it deserves. Except for incidental references, the major figures of food and drug regulation at the local level have been largely ignored by historians. Lucius Polk Brown’s quest for pure food and drugs is representative of what municipal and state officials, as scientific people, encountered when they fought for the passage of new laws, struggled to enforce existing ones, and battled with the politicians, quacks, ignorance that threatened their efforts.Brown’s diversified career provides a unique opportunity for studying a scientific reformer caught up in the political turmoil of the Progressive era. His experience in government service spanned twelve years and touched on two dissimilar political systems. In focusing on Brown’s struggles, achievements, and failures, Margaret Ripley Wolfe provides a comparative study of state and municipal health administrations, of bureaucratic development in a rural southern state and a northern metropolis. For that reason this book should be of interest to political scientists and public health officials as well as to social historians and students of the Progressive era.
Leaders of Reform
Authors: La Forte Robert Sherman 
Published: April 2022

In Leaders of Reform Robert Sherman La Forte examines the intricacies of shifting factions within the state majority party over a two decade period, from the Boss-Busters and political machines of the early 1900s through the formation of a new party behind Theodore Roosevelt in 1913. He discusses the motives, activities, accomplishments, and failures of the progressive Republicans. He provides excellent vignettes of major leaders such as William Allen White, Arthur Capper, Joseph L. Bristow, and Charles Curtis, as well as lesser-known characters such as Walter Roscoe Stubbs, Edward H. Hoch, and Cy Leland, Jr.In providing a detailed analysis of virtually all Kansas progressive Republican leaders during the era, La Forte has made a valuable contribution to both state and national political history.
The President as Statesman
Authors: Stid Daniel D. 
Published: April 2022

A political scientist who went on to become president, Woodrow Wilson envisioned a "responsible government" in which a strong leader and principled party would integrate the separate executive and legislative powers. His ideal, however, was constantly challenged by political reality. Daniel Stid explores the evolution of Wilson's views on this form of government and his endeavors as a statesman to establish it in the United States. The author looks over Professor and then President Wilson's shoulder as he grappled with the constitutional separation of powers, demonstrating the importance of this effort for American political thought and history.Although Wilson is generally viewed as an unstinting and effective opponent of the separation of powers, the author reveals an ambivalent statesman who accommodated the Founders' logic. This book challenges both the traditional and revisionist views of Woodrow Wilson by documenting the moderation of his statesmanship and the resilience of the separation of powers. In doing so, it sheds new light on American political development from Wilson's day to our own.Throughout the twentieth century, political scientists and public officials have called for constitutional changes and political reforms that were originally proposed by Wilson. By reexamining the dilemmas presented by Wilson's program, Stid invites a reconsideration of both the expectations we place on the presidency and the possibilities of leadership in the Founders' system. The President as Statesman contributes significantly to ongoing debates over Wilson's legacy and raises important questions about the nature of presidential leadership at a time when this issue is at the forefront of public consciousness.
Our Limits Transgressed
Authors: Taylor Bob Pepperman 
Published: April 2022

Is democracy hazardous to the health of the environment?Addressing this and related questions, Bob Pepperman Taylor analyzes contemporary environmental political thought in America. He begins with the premise that environmental thinking is necessarily political thinking because environmental problems, both in their cause and effect, are collective problems. They are also problems that signal limits to what the environment can tolerate. Those limits directly challenge orthodox democratic theory, which encourages expanding individual and political freedoms and is predicated on growth and abundance in our society. Balancing the competing needs of the natural world and the polity, Taylor asserts, must become the heart of the environmental debate.Contemporary environmental thinking derives, according to Taylor, from two well-established traditions in American political thought. The pastoral tradition, which he traces from Thoreau through John Muir to today's deep ecology, biocentrism, and Green movement, appeals to moral lessons that nature can teach us. The progressive tradition—which he traces from Gifford Pinchot to the apostate neo-malthusians (who reject the commitment to democratic equality) and liberal theorists like Roderick Nash, Christopher Stone, and Mark Sagoff—focuses on the role that nature plays in supporting a liberal democratic society. This analysis sidesteps the usual anthropocentric-biocentric formulation of the debate, which tends to center on the most appropriate conception of nature abstractly considered, and reorients the discussion to a consideration of the relationship between our political and environmental values. If we are to stem the thoughtless pillaging of the environment, Taylor contends, that's where the changes must occur.Any satisfactory resolution of the tension between the garden and the machine must draw upon the best of both the pastoral and progressive traditions, Taylor concludes. The best of pastoralism teaches us that any reform must challenge the human arrogance and crude materialism that permeates much of liberal society.In addition to Nash, Stone, and Sagoff, Taylor discusses other contemporary thinkers such as Garrett Hardin, Paul Ehrlich, Robert Heilbroner, William Ophuls, Julian Simon, Robert Paehlke, J. Donald Moon, Kirkpatrick Sale, J. Baird Callicott, Holmes Rolston, Paul Taylor, Barry Commoner, and Murray Bookchin.
New Governance for Rural America
Authors: Radin Beryl A. , Agranoff Robert , Bowman Ann O’M. , Buntz C. Gregory , Ott J. Steven , Romzek Barbara S. , Wilson Robert 
Published: April 2022

Throughout the 1990s public demand for a fundamental shift in the relationship between government and its citizens has intensified. In response, a "new governance" model has emerged, emphasizing decreased federal control in favor of intergovernmental collaboration and increased involvement of state, local, and private agencies.As the authors of this volume show, one of the best examples of "new governance" can be found in the National and State Rural Development Councils (NRDC and SRDC), created in 1990 as the result of President Bush's Rural Development Initiative and now called the Rural Development Partnership. This effort was part of a move within policymaking circles to redefine a rural America that was no longer synonymous with family farming and that required innovative new solutions for economic revival. By 1994 twenty-nine states had created and ten other states were in the process of forming such councils.In this first detailed analysis of the NRDC and SRDCs, the authors examine the successes and failures of the original eight councils in Kansas, Maine, Mississippi, Oregon, South Carolina, South Dakota, Texas, and Washington; as well as eight other councils subsequently created in Iowa, New Mexico, North Carolina, Vermont, New York, North Dakota, Utah, and Wyoming.Combining empirical analysis with current theories about networks and inter-organizational relations, this volume should appeal to academics and practitioners interested in rural development policy, public administration, public policy and management, and intergovernmental relations.
Psychological symptoms associated with self-reported events of COVID-19 contact, symptoms, or diagnosis: a large community-based survey among adults in Quebec, Canada
Authors: Généreux Mélissa , Landaverde Elsa 
Published: April 2022

Abstract
Objectives
Psychological consequences of COVID-19 contact, symptoms, or diagnosis are being increasingly reported. Few studies have examined the psychological effects tied to these events, using an unaffected comparison group. Most did not consider confounding factors like fear and stigma. This study aims to (1) identify individual characteristics associated with COVID-19 contact/symptoms or diagnosis and (2) examine the independent association between COVID-19 contact/symptoms or diagnosis and psychological symptoms.

Methods
From September 2020 to February 2021, 20,327 adults participated in community-based surveys in Quebec. Using repeated cross-sectional online questionnaire, data were collected on probable generalized anxiety disorder (GAD) and major depression episode (MDE), using the GAD-7 and the PHQ-9 scales, respectively. Self-reported events of (1) contact with a case or symptoms of COVID-19, and (2) diagnosis of COVID-19 were examined, along with several sociodemographic and pandemic-related factors.

Results
COVID-19 contact, symptoms, or diagnosis was more frequent in young adults, healthcare or social services workers, adults living with children, and those reporting a greater sense of threat, stigma, financial losses, or daily stress. COVID-19 contact or symptoms and diagnosis were associated with probable MDE relative to the unaffected group (adjusted odds ratio [aOR]: 1.25, 95% CI: 1.12–1.39 and aOR:1.82, 95% CI: 1.48–2.2, respectively). Suicidal thoughts and psychomotor retardation were the symptoms most closely associated with a COVID-19 diagnosis.

Conclusion
Results from this study stress the need for better understanding, recognition, and support for people suffering from psychological symptoms following a COVID-19 diagnosis.
Antiepileptic drugs in treating structural epilepsy of patients with metastatic brain cancer: a combination approach
Authors: Shershever A. S. , Lavrova S. A. , Bentsion D. L. , Makhnev V. V. , Kulakova A. S. , Zafirova M. A. , Sorokova E. V. 
Published: April 2022

Objective: to study the effect of perampanel on the dynamics of epileptic seizures and anxiety in patients with brain metastases and epileptic seizures during chemotherapy (CT), radiotherapy (RT), and radiochemotherapy (RCT).Material and methods. The prospective clinical study included 48 patients with lung cancer and 39 women with breast cancer who underwent removal of primary focus. After CT, RT or RCT epileptic seizures were registered. Brain metastases were revealed at brain magnetic resonance imaging data. All patients underwent general and neurological examination as well as electroencephalography. The level of anxiety was assessed by the Beck Anxiety Inventory. Рatients were prescribed perampanel by the concilium decision.Results. It was shown that administered perampanel was effective in any primary tumor location. The quantity of repeated epileptic seizures in all patients with lung and breast metastatic cancer was significantly decreased on Day 6–7 after adding perampanel to either earlier received antiepileptic drugs or as a monotherapy (p=0.0431). In the follow-up period with the median survival rate of 8–13 months, the frequency of epileptic seizures was decreased and then remained stable. Perampanel as mono- or multitherapy positively influenced on controlling anxiety disorders in 25–75% patients with brain metastases.The level of anxiety was decreased due to lowered epileptic activity.Conclusion. Based on the study results, we could recommend administration of perampanel for the treatment of metastatic brain cancers in patients with diverse primary tumors as well as both partial and generalized epileptic seizures while applying CT, RT, RCT or palliative care.
Epilepsy in Norrie disease
Authors: Aysina V. A. , Kozhevnikova О. V. , Osipova О. V. , Lashkova A. V. 
Published: April 2022

The insight into the Norrie disease viewed from neurology perspective and clinical case of refractory epilepsy relevant to the disease are considered. Epilepsy rarely accompanies Norrie disease. The dynamics of changes in electroencephalograms (EEG) and types of epileptic seizures during the disease progression as well as depending on the therapy received in the clinical case is analyzed. It is relevant for patients with Norrie disease to regularly undergo video-EEG monitoring to detect epileptiform activity, ictal patterns for timely diagnostics of epilepsy followed by prescribing proper therapy to improve quality of life.
Amplitude-integrated electroencephalography as an additional research method in newborns with seizures
Authors: Koshchavtsev A. G. 
Published: April 2022

Objective: to compare the methods of electroencephalography (EEG) and amplitude-integrated electroencephalography (aEEG), related technical features, their clinical application in newborns at the intensive care unit, as well as a correlation between aEEG and other diagnostic methods (neurological status, neurosonography).Material and methods. Fifty-two newborns were examined who mainly born at full-term or had an initial degree of prematurity. In 29 infants, seizures were recorded, which were noted 1–5 times. An EEG was performed within 107.7±32.7 minutes followed by further software aEEG processing.Results. While analyzing aEEG, significant differences were found among the indices of delta 2 activity denoted as a percentage in premature vs. full-term infants relative to other rhythms. It was shown that prevalence of high-amplitude delta 2 activity throughout entire recording presented as percentage was higher in infants with vs. without seizures.Conclusion. It was demonstrated that aEEG clarifies and supplements the data obtained with routine EEG, and can be used not only for conducting continuous monitoring of neonatal brain functions, but also as an additional program to a standard EEG study. The method has a great potential for specifying diagnosis and further neonatal neurological support at intensive care units.
Idiopathic and symptomatic forms of genetic epilepsy
Authors: Malov A. G. 
Published: April 2022

According to the new classification of the epilepsies proposed in 2017 by The International League Against Epilepsy, idiopathic epilepsies are recommended to refer to genetic epilepsy, suggesting to consider the term “idiopathic” as outdated. In connection with this, a tendency arose to refer forms of epilepsy previously called “idiopathic” as genetic epilepsy. However, idiopathic epilepsy constitutes just a part among genetic epilepsies. The other groups resulting from this etiology are monogenic epilepsies (e.g., Dravet syndrome) as well as symptomatic epilepsies due to other genetically determined syndromes (e.g., biotinidase deficiency or neuronal ceroid lipofuscinosis). The distinction between the three groups comprising genetic epilepsy is important not only due to difference in related etiology and course, but also because specific treatment in some monogenic forms might be possible. Here, the major criteria for distinguishing between such epilepsy groups are presented.
Autoimmune epilepsy
Authors: Shilkina О. S. , Kantimirova E. A. , Usoltseva A. A. , Prusova Т. I. , Dmitrenko D. V. 
Published: April 2022

Investigation of autoimmune epilepsy (AIE) has been attracting increasingly more attention due to discovery of neuronal antibodies and improved understanding of the mechanisms related to such immune-mediated syndromes. The review is aimed at autoimmune epilepsy taking into account up-to-date advances in exploring its pathophysiology. Definitions related to this issue are outlined, and pathogenetic mechanisms, features of antineuronal antibodies as well as AIE clinical picture based on type of autoantibodies, are considered. The necessity of regular monitoring patients with AIE is indicated, preferably by an epileptologist together with a neuroimmunologist. With prolonged follow-up, chronic pharmacoresistant epilepsy persists in some patients, despite aggressive immunotherapy and antiepileptic drugs. With a deeper understanding of the mechanisms of antibody-mediated and autoantigen-specific T-cell-mediated AIE syndromes, the use of antiepileptic drugs and immunotherapy can be further optimized.
The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech
Authors: Morozova E. A. , Belousova M. V. , Morozov D. V. , Utkuzova M. A. 
Published: April 2022

The article presents a case report, and a literature review on benign epileptiform discharges of childhood (BEDC) as well as effect of this type of epileptiform activity on speech, behavior and communication skills are analyzed. The incidence of BEDC comprises 5% in pediatric population. Examining children with autistic spectrum disorder, BEDC is revealed in 20% cases, whereas in those with attention deficit and hyperactivity disorder (ADHD) or speech disorder – in 25% and 18% cases, respectively. Many studies considering BEDC as a genetic marker of brain immaturity highlighted by different level of expressiveness and penetrance are discussed. It is highly probable that cognitive and speech disorders as well as ADHD in children with BEDC may be genetically determined. However, pediatric BEDC may be asymptomatic or become manifested by diverse psychoneurological symptoms accounted for by developed epileptic encephalopathy and continuous spike and waves during slow wave sleep (CSWS) requiring specialized long-term treatment. Markedly elevated CSWS with morphological BEDC affects interneuron connections, which, in turn, alters memory consolidation in mesial temporal regions. The literature analysis revealed that children with BEDC-like epileptic activity require obligatory periodic sleep electroencephalographic control and dynamic neuropsychological evaluation due to high incidence of speech, mnestic and behavioral disorders. Seizure-free BEDC-like epileptic activity should be corrected pharmaceutically only in case of established causative link with progressive cognitive impairments.
Myoclonic epilepsy with ragged red fibers in childhood
Authors: Tadtaeva Z. G. , Galustyan A. N. , Krivdina М. Yu. , Rusanovsky V. V. , Efet E. A. , Krivoshein A. Е. , Kuritsyna N. A. , Gromova О. A. 
Published: April 2022

Myoclonic epilepsy with ragged red fibers (MERRF) is a maternally inherited disease characterized by myoclonic epilepsy, cerebellar ataxia and progressive muscle weakness. Development of the disease is associated with the most common (90% of cases) point mutation at position 8344 in the mitochondrial lysine transport RNA gene – MTTLys. The disease diagnostics causes certain difficulties due to the insufficient awareness of this pathology and polymorphism of clinical manifestations. The article presents a brief review of the literature data on current views on the disease pathogenesis, diagnostic methods and opportunities for drug treatment, and describes a clinical observation of a 7-year-old child with MERRF syndrome caused by a point mutation at position 8344 in the MTTLys gene. The girl was under dynamic supervision at the neuropsychiatric department. A comprehensive clinical, laboratory and instrumental examination was carried out that also included molecular genetic testing. The progredient progression and multiple symptoms of the disease, slightly increased lactate acidosis in the absence of typical neuroimaging and electromyographic changes are of interest in the observation, thereby confirming they might not necessarily be observed in MERRF. Intrafamily clinical diversity was noted in the absence of signs of the disease in paired mother. A highly informative method of MERRF diagnostics is provided by molecular genetic testing. Establishing a genetic diagnosis underlies a need for conducting medical and genetic counseling for family planning to prevent the re-birth of other sick siblings inheriting this pathology.
Neurological disorders after hysterectomy: from pathogenesis to clinical manifestations
Authors: Solopova A. G. , Blinov D. V. , Begovich E. , Sandzhieva L. N. , Demyanov S. V. , Demyanov G. V. 
Published: April 2022

Hysterectomy currently occupies one of the leading places among obstetric and gynecological surgeries and is one of the highly effective and sometimes the only method of treating various diseases of the female genital organs. Quite often, however, hysterectomy results not only in the elimination of the cause of disease, but also in the development of complications that reduce the quality of life of patients. More and more attention is being paid to neurological complications, which is obviously due to improved diagnostic capabilities, as well as the results of recent research on the pathogenesis and treatment of neurological disorders. Only recently the scientists have begun to think about the true causes of one of the most important neurologic complications of hysterectomy, namely chronic postoperative pain.The review describes in detail the main neurological disorders that develop after hysterectomy: chronic postoperative pain, traumatic neuroma, residual ovarian syndrome as possible causes of chronic pain, mononeuropathies, sexual and sleep disorders, decreased cognitive and motor functions, lower urinary tract and bowel dysfunction. Considerable attention is given to the mechanisms of neurological complications and the relationship between the surgery and emotional disturbances in women.