bluuebunny/crossref_metadata_2025_split huggingface dataset:
O Plano Diretor e a regionalização como ferramenta do planejamento de Campinas: uma análise da região do Jardim Campo Belo
Authors: Mestre Ana Paula , Fonseca Helena Rizzatti 
Published: April 2022

Nesse artigo nos propomos a questionar a malha territorial utilizada pelo Plano Diretor de 2006 de Campinas, com ênfase nas regionalizações por Macrozonas e Planos Locais de Gestão que dão base para a operacionalização do planejamento municipal e para a perspectiva de participação popular. Tal análise é feita a partir da região do Jardim Campo Belo: área periférica localizada no extremo sul da cidade e retrato do atual momento de periferização de Campinas. Buscamos expor os princípios que regeram as regionalizações do Plano e como essas divisões intra-urbanas se tornam um bloqueio da comunicação entre o lugar e a Prefeitura, situação que dificulta a possibilidade de uma gestão territorial compartilhada.
Complexos industriais, circuitos espaciais produtivos e direito reflexivo
Authors: Antas Jr. Ricardo Mendes 
Published: April 2022

O artigo analisa algumas diferenças básicas dos complexos industriais em relação ao período fordista e ao que o sucede, especialmente no que tange à indústria de alta tecnologia. Os complexos industriais atuais de alta tecnologia já nascem especializados em algum tipo de tecnologia sofisticada, e não alta tecnologia de um modo geral conforme era tratado na década de 1980, e em grande medida são constituídos por circuitos espaciais produtivos. Isto implica numa diferenciação profunda em relação ao passado, pois os circuitos espaciais produtivos são planetários, transnacionais, e comandados em grande medida por corporações dos setores implicados. Ao mesmo tempo os complexos industriais são nacionais já que são incentivados e subsidiados direta e indiretamente pelo Estado e também são constituídos por empresas nacionais pequenas, médias e grandes. Por fim discutimos como os círculos de cooperação no espaço vem baseando as suas ações de promoção à cooperação capitalista por meio do desenvolvimento do direito reflexivo utilizando formas de judicialização não-estatais ou soberanas.
HUBUNGAN BERAT BAYI LAHIR DENGAN PERTUMBUHAN PADA BATITA DI PRAKTIK MANDIRI BIDAN NURVITA SARI DESA SIMPANG CAMPANG OKU SELATAN TAHUN 2020
Authors: Anggraini Ririn , Yupita Pini Milenia , A. Rahman Su’aidy , Rusmiana Raty 
Published: April 2022

Basic growth that takes place from toddler to preschool will affect the development and growth of the child then. LBW babies can affect growth because since the womb, they have experienced intrauterine growth retardation. The purpose of this study was to determine the relationship between birth weight and growth in toddlers at PMB Nurvita Sari, South OKU Simpang Campang Village in 2020. This study used a cross sectional research design. The researcher used total sampling to take a sample. The results obtained from 50 respondents who were born normally as many as 42 respondents (84%), and LBW by 8 respondents (16%). And of the 50 baby respondents who experienced normal growth as many as 34 respondents (68%) and not normal as many as 16 respondents (32%). The results of the study on the relationship between birth weight and body weight / height (BB/TB) showed a p value of 0.900> 0.05, it means that there was no significant relationship between birth weight and body weight / height (BB/TB). The relationship between birth weight and height / age (TB/U) showed a p value of 0.079> 0.05, meaning that there was no significant relationship between birth weight and height for age (height / age). And the relationship between birth weight and growth shows a p value of 0.716> 0.05, which means that there was no significant relationship between birth weight and growth in toddlers. So the conclusion of this study is there was no relationship between birth weight and growth in toddlers. In this study, the secondary data did not contain head circumference data, so it is hoped that the health workers at PMB Nurvita Sari will better understand the importance of the head circumference indicator, so that growth monitoring in children can be monitored effectively.
De Innovatiewet Strafvordering: meeliften op een hype?
Authors: Jacobs M.J. 
Published: April 2022

Innovatiewet Strafvordering: meeliften op een hype?
In het kader van de modernisering van het Wetboek van Strafvordering werd afgelopen zomer een interessant wetsvoorstel bij de Tweede Kamer ingediend: de ‘Innovatiewet Strafvordering’. Deze innovatiewet heeft namelijk als doel om alvast ervaring op te doen met een zestal procedures, bevoegdheden en instrumenten waarvan het de bedoeling is dat die te zijner tijd een plaats krijgen in het nieuwe Wetboek van Strafvordering. Op een na (waarover later meer) staan alle procedures die in de Innovatiewet Strafvordering staan ook in de in 2020 openbaar gemaakte ambtelijke versie van het Wetsvoorstel tot vaststelling van het nieuwe Wetboek van Strafvordering. Daaruit kan worden afgeleid dat de regering van vijf van de zes procedures al weet dat zij deze onderwerpen in het nieuwe Wetboek van Strafvordering wil opnemen. Het opdoen van ervaring is erop gericht om eventuele ‘kinderziektes’ in de nieuwe procedures vroegtijdig aan het licht te laten komen en te verhelpen.
СУЧАСНІ ТЕНДЕНЦІЇ ТА АКТУАЛЬНІ ПРОБЛЕМИ ПІДГОТОВКИ МЕНЕДЖЕРА МАРКЕТИНГОВИХ КОМУНІКАЦІЙ
Authors: Лікарчук Н. , Ярвіс М. , Вареник O. , Малихіна С. , Коноплянникова M. 
Published: April 2022

Анотація. У статті висвітлюються особливості підготовки менеджера маркетингових комунікацій в реаліях сучасного соціокультурного простору. Актуальність роботи полягає у зміні пріоритетів навчального кластеру для економічних дисциплін за нових умов функціонування ринкових складників. Пандемія COVID-19 стала своєрідним стимулом для розробки та впровадження нових моделей маркетингових комунікацій. Як наслідок, програми та курси для спеціалістів цього фаху також потребують трансформації. Формування необхідних знань, умінь і навичок для фахівця економічної сфери передбачає дотримання кількох ключових настанов, серед яких відзначимо: динамічність навчальних програм, синергетичний складник міждисциплінарного підходу, безперервність фахової підготовки, орієнтація на підвищення ефективності роботи, баланс між економічною вигодою та морально-етичними цінностями. Здобуття фаху менеджера маркетингових комунікацій передбачає отримання базової економічної освіти та постійне удосконалення своє кваліфікації у відповідності до практичної діяльності. Метою статті є розробка актуального формату організації навчання та підвищення кваліфікації для спеціалістів економічного профілю. Використання методу порівняльного аналізу та синергетичної методології забезпечує різностороннє дослідження проблеми підготовки менеджерів маркетингових комунікацій. Потреба в нових форматах торгівельної активності породжує попит на фахівців з новими професійними здібностями, здатними демонструвати ефективність в роботі. Відтак, освітній економічний кластер активізує увесь свій методологічний арсенал для розробки нових навчальних курсів підготовки не просто працівника, а лідера в менеджерській ланці. Актуальні маркетингові знання стають основою для успішної професійної діяльності спеціаліста менеджерського кластеру економічної сфери.
Ключові слова: економічна освіта, маркетингові комунікації, маркетологічні тренінги, менеджер, реклама.
Формул: 0; рис.: 1, табл.: 1, бібл.: 15.
Sikap Netral Alumni STIP-AN Sebagai Aparatur Sipil Negara Dalam Mengimplementasikan Kebijakan Pemerintahan DI Era Demokratisasi Kehidupan Politik
Authors: Hamim Sofyan Safari 
Published: April 2022

Neutral attitude of alumni of STIP-AN as civil servant and as The Indonesian Civil Service Corps (Korpri) member on implementing the goverment policies in democratization era of political life will be run well, if it started from the system of servant recruitment, and the development with servant safety webs system consist of basic measurement, purepose, source of neutrality policies, communication between organizaions, characteristic of implementing agent, and inclination of implementer, and also supporting tolls. Neutrality will be related to professionalism and servant's welfare which its quality depends on bureaucracy ethics and social ethics that have equality value and individual rights guaranty.
The implementation of neutral attitude of civil servant of The Indonesian Civil Service Corps (Kopri) is as service action, empowerment and the development which is did by civil servant of The Indonesia Civil Service Corps (Korpri) member for reaching purpose consist of effort to discuss, to create the common good about all the things of state administation and regional on finding and maintaining authority, formulating and implementing public policies, also finding and maintaining the important resources. For the run of goverments wheel in effective, efficient and equity for the implementation of national and regional development, hope that this can be understandable, respected in propotional, in consistency by alumni of STIPAN as civil servant of The Indonesia Civil Service Corps (Korpri) and all of nation components
The Evaluation of Effectiveness, or How Do We Know Whether a Treatment Works in Real Life? Part 2
Authors: Schindler Thomas , Bridge Helen 
Published: April 2022

In our previous article (Schindler TM, Bridge H. The evaluation of efficacy, or how do we know whether a treatment works? Part 1. AMWA J. 2020;35(2):82-86), we described how randomized clinical trials (RCTs) determine efficacy of a treatment. Efficacy is generally understood as the ability of a drug or other intervention to reliably produce a positive effect in patients with a defined disease under controlled conditions. In other words, clinical trials are good tools to evaluate efficacy. Clinical trials provide a well-controlled framework that is characterized by the following:
• Selecting participants according to clearly defined eligibility criteria• Randomly allocating participants to treatment groups• Concealing study treatments to participants and study doctors (blinding)• Clearly defining endpoint measures before study start
Provided a drug consistently demonstrates efficacy in several clinical studies and appears safe, regulators will approve it and permit its marketing for the treatment of a disease. However, once a drug is on the market, it will be used for the entire spectrum of patients and under circumstances that might not have been tested in the clinical studies. For example, the new drug will be used in patients who have several comorbidities in addition to the approved indication. The evaluation of a drug’s effects under everyday conditions is called effectiveness research.
Hubungan Minat Baca dan Kecerdasan Interpersonal Siswa terhadap Hasil Belajar IPS Siswa Kelas IV MI Muhammadiyah Al-Manar Demak
Authors: Nashihah Innayatun , Auliya Nanang Nabhar Fakhri 
Published: April 2022

This study aims to obtain several findings, namely 1) there is a relationship between the variables of reading interest and interpersonal intelligence on learning outcomes in social studies subjects in grade IV. 2) there is an indirect effect of reading interest on social studies learning outcomes through interpersonal intelligence. The population in this study were 30 students, all of which were 30 students who were also the sample in this study. The data analysis technique uses path analysis with the help of the SPSS version 25 application as a tool for processing and research. The results showed that the variables of reading interest and interpersonal intelligence had an effect and were significant on the social studies learning outcomes variable in the odd semester of TP 2020/2021. The direct effect of reading interest and interpersonal intelligence on learning outcomes is 0.179 or 17.9% and the effect of mediation on reading interest on learning outcomes through interpersonal intelligence is 1.97 or 1.97%.
Keywords: Reading Interest, Interpersonal Intelligence, and Social Studies Learning Outcomes
Ketidaktahuan Pelaku Usaha sebagai Alasan Keterlambatan Notifikasi Merger dan Akuisisi (Implementasi Peran KPPU dalam Penanganan Merger dan Akuisisi di Masa Pandemi Covid-19)
Authors: Murniati Rilda 
Published: April 2022

Hukum Persaingan Indonesia menganut sistem post-merger notification setelah tanggal berlaku efektif yuridis merger dan akuisisi telah mengakibatkan keterlambatan notifikasi oleh pelaku usaha. Di masa pandemi Covid-19, kurun waktu 1 tahun lebih (11 Februari 2020 sampai dengan 11 April 2021), KPPU telah memeriksa dan memutus 17 (tujuh belas) perkara keterlambatan notifikasi yang memenuhi batasan nilai aset dan/atau nilai penjualan dan berakibat wajib dinotifikasi tetapi terlambat karena ketidaktahuan pelaku usaha. KPPU dalam putusan menjadikan ketidaktahuan pelaku usaha sebagai alasan yang meringankan sanksi denda keterlambatan. Majelis KPPU dalam 6 (enam) putusannya memberlakukan ketentuan penyerahan salinan dokumen jaminan bank sebesar 20% (dua puluh persen) dari nilai denda kepada KPPU paling lama 14 (empat belas) hari kerja setelah menerima pemberitahuan putusan ini, jika Terlapor mengajukan keberatan. Di masa mendatang, diharapkan KPPU menjadikan alasan ketidaktahuan pelaku usaha sebagai alasan memberatkan karena kebijakan notifikasi ini telah berlaku sejak ditetapkannya PP No.57 Tahun 2010.
Kata Kunci: Merger, Notifikasi, Keterlambatan, Ketidaktahuan.

AbstractIndonesia’s Competition Law adopts a post-merger notification system after the legally effective date of merger and acquisition has resulted in notification delays by business actors. During the Covid-19 pandemic, for more than 1-year (11 February 2020 to 11 April 2021), KPPU has examined and decided 17 (seventeen) cases of late notification which meet the limits on asset value and/or sales value and result in mandatory notification but late because of ignorance of business actors. KPPU in its decision made the ignorance of business actors as a reason to ease the late penalty fine. The KPPU Assembly in its 6 (six) decisions enforces a provision for submitting a copy of the bank guarantee document in the amount of 20% (twenty percent) of the value of the fine to the KPPU no later than 14 (fourteen) working days after receiving the notification of this decision if the Reported Party submits an objection. In the future, it is hoped that KPPU will use the reasons for the ignorance of business actors as a burdensome reason because this notification policy has been in effect since the enactment of Government Regulation No. 57 of 2010.
Keywords: Merger, Notification, Delay, Ignorance.
Le grand tournant du pontificat de François: changements et perspectives dans l'Eglise famille de Dieu en Afrique
Authors: Faye Anne Béatrice 
Published: April 2022

Le pape François se retrouve à la tête d’une Eglise confrontée à de grandes difficultés. Il a lancé et poursuivi des chantiers que son prédécesseur a eu du mal à faire avancer. Il a su se placer au centre des discussions essentielles de notre époque : la richesse et la pauvreté, l'équité et la justice, la transparence, la modernité, la mondialisation, le rôle de la femme, l’ouverture de la prêtrise aux femmes, la nature du mariage, l’accueil des divorcés remariés, les tentations du pouvoir, les relations avec l'islam, la lutte contre la pédophilie, les finances du Saint-Siège, l’abolition du célibat ecclésiastique, la gouvernance de l'Eglise, la redynamisation de la foi en Europe. Même si nous n’allons pas aborder tous ces thèmes, le pape pour sa part n’a guère d’autres solutions que de poursuivre dans la route déjà empruntée pour une Église à géométrie variable. Au-delà de sa personne, il s’agit de l’Eglise et, surtout de l’accueille du Christ par notre société contemporaine dans sa diversité culturelle. Ce qui est frappant c’est de voir comment le Pape François catalyseur, conçoit son ministère à travers l’écoute des pasteurs qui ont eux-mêmes écouté le peuple. Il insiste souvent sur l’enjeu de la liberté de parole et de débat. D’où la place que nous avons à la riche culture africaine.
Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians
Authors: Ubaida-Mohien Ceereena , Spendiff Sally , Lyashkov Alexey , Moaddel Ruin , MacMillan Norah J , Filion Marie-Eve , Morais Jose A , Taivassalo Tanja , Ferrucci Luigi , Hepple Russell T 
Published: April 2022

Background:Master athletes (MAs) prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their high function remain unclear.Methods:We performed muscle biopsies in 15 octogenarian world-class track and field MAs and 14 non-athlete age/sex-matched controls (NA) to provide insights into mechanisms for preserving function in advanced age. Muscle samples were assessed for respiratory compromised fibers, mitochondrial DNA (mtDNA) copy number, and proteomics by liquid-chromatography mass spectrometry.Results:MA exhibited markedly better performance on clinical function tests and greater cross-sectional area of the vastus lateralis muscle. Proteomics analysis revealed marked differences, where most of the ~800 differentially represented proteins in MA versus NA pertained to mitochondria structure/function such as electron transport capacity (ETC), cristae formation, mitochondrial biogenesis, and mtDNA-encoded proteins. In contrast, proteins from the spliceosome complex and nuclear pore were downregulated in MA. Consistent with proteomics data, MA had fewer respiratory compromised fibers, higher mtDNA copy number, and an increased protein ratio of the cristae-bound ETC subunits relative to the outer mitochondrial membrane protein voltage-dependent anion channel. There was a substantial overlap of proteins overrepresented in MA versus NA with proteins that decline with aging and that are higher in physically active than sedentary individuals. However, we also found 176 proteins related to mitochondria that are uniquely differentially expressed in MA.Conclusions:We conclude that high function in advanced age is associated with preserving mitochondrial structure/function proteins, with underrepresentation of proteins involved in the spliceosome and nuclear pore complex. Whereas many of these differences in MA appear related to their physical activity habits, others may reflect unique biological (e.g., gene, environment) mechanisms that preserve muscle integrity and function with aging.Funding:Funding for this study was provided by operating grants from the Canadian Institutes of Health Research (MOP 84408 to TT and MOP 125986 to RTH). This work was supported in part by the Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA.
A model of multiple tumor marker for lymph node metastasis assessment in colorectal cancer: a retrospective study
Authors: Fu Jiangping , Tu Mengjie , Zhang Yin , Zhang Yan , Wang Jiasi , Zeng Zhaoping , Li Jie , Zeng Fanxin 
Published: April 2022

Background
Assessment of colorectal cancer (CRC) lymph node metastasis (LNM) is critical to the decision of surgery, prognosis, and therapy strategy. In this study, we aimed to develop and validate a multiple tumor marker nomogram for predicting LNM in CRC patients.

Methods
A total of 674 patients who met the inclusion criteria were collected and randomly divided into primary cohort and internal test cohort at a ratio of 7:3. An external test cohort enrolled 178 CRC patients from the West China Hospital. Clinicopathologic variables were obtained from electronic medical records. The least absolute shrinkage and selection operator (LASSO) and interquartile range analysis were carried out for variable dimensionality reduction and feature selection. Multivariate logistic regression analysis was conducted to develop predictive models of LNM. The performance of the established models was evaluated by the receiver operating characteristic (ROC) curve, calibration belt, and clinical usefulness.

Results
Based on minimum criteria, 18 potential features were reduced to six predictors by LASSO and interquartile range in the primary cohort. The model demonstrated good discrimination and ROC curve (AUC = 0.721 in the internal test cohort, AUC = 0.758 in the external test cohort) in LNM assessment. Good calibration was shown for the probability of CRC LNM in the internal and external test cohorts. Decision curve analysis illustrated that multi-tumor markers nomogram was clinically useful.

Conclusions
The study proposed a reliable nomogram that could be efficiently and conveniently utilized to facilitate the assessment of individually-tailored LNM in patients with CRC, complementing imaging and biopsy tests.
A long noncoding RNA GTF2IRD2P1 suppresses cell proliferation in bladder cancer by inhibiting the Wnt/β‑catenin signaling pathway
Authors: Huang Zhuo , Gao Hongbin , Qing Liangliang , Wang Biao , He Chaoyong , Luo Ning , Lu Chuncheng , Fan Shipeng , Gu Peng , Zhao Hui 
Published: April 2022

Background
There is growing evidence that long non-coding RNAs (LncRNAs) are key in the development of a variety of human tumors. However, the role of lncRNA GTF2IRD2P1 has not been well studied in cancer. The impact of GTF2IRD2P1 on the biological function and clinical relevance in bladder cancer is largely unknown. This study aimed to investigate the biological role of GTF2IRD2P1 in bladder evolution and carcinogenesis.

Methods
We used bioinformatics to obtain the lncRNA GTF2IRD2P1 from bladder urothelial carcinoma (BLCA) in The Cancer Genome Atlas (TCGA) database. The expression of lncRNA GTF2IRD2P1 was detected by qRT-PCR. The CCK8 assay and flow cytometry were used to detect the lncRNA GTF2IRD2P1 function on the proliferation of bladder cancer cells. A western blot was used to calculate the protein level of cell cycle proteins and Wnt signaling pathway proteins. The effect of lncRNA GTF2IRD2P1 on tumorigenesis of bladder cancer was confirmed by a xenograft nude mouse model.

Results
GTF2IRD2P1 expression was found to be lower in both human bladder cancer tissues and cell lines (UM-UC-3, RT4, and 5637), and elevated in T24 compared to the corresponding normal controls. GTF2IRD2P1 expression was also enhanced after transfection of UM-UC-3 cells with the overexpression vector. Meanwhile, overexpression of GTF2IRD2P1 inhibited the proliferation of UM-UC-3 and prolonged the cell cycle. The silencing of GTF2IRD2P1 significantly increased the proliferation and shortened the cell cycle of T24 cells and induced Wnt signaling activity to promote the progression of bladder cancer. Similarly, the transplanted tumor nude mouse model demonstrated that silencing GTF2IRD2P1 strengthens the progression of bladder cancer by targeting the Wnt signaling pathway.