bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigations on the co-occurrence of microplastics and other pollutants in the River Yamuna, Delhi
Authors: Vaid Mansi , Mehra Komal , Sarma Kiranmay , Gupta Anshu 
Published: November 2022

Abstract
The Yamuna River is a threatened resource of freshwater in Delhi, India. The present study is focused on investigating three important contaminants, namely microplastics (MPs), heavy metals, and fecal coliforms in the surface water of the river, with major emphasis on MPs occurrence and characterization. MPs showed an increase in abundance in the river from the Wazirabad barrage (n = 500 MPs/m3) to the Okhla barrage downstream (n = 3,900 MPs/m3) in Delhi, with a maximum abundance downstream to the Najafgarh and Shahdara drain outfalls. White color and fragmented shape were prevalent characteristics of the isolated MPs. Attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectroscopy revealed five types of polymers. Heavy metals (chromium, lead, manganese, and iron) and fecal coliforms were at unacceptable levels at most of the sampling sites. Due to the emergence of issues concerning the tendency of MPs to actively interact with heavy metals and pathogenic microorganisms, investigation of the co-occurrence of such harmful pollutants is very important. The present study is aimed at this issue and urges similar kinds of investigations in other riverine regions of our country, as well as globally, due to their scarcity in literature. This study can further provide a baseline database to help the Government of India's efforts to clean and revive the Delhi stretch of the Yamuna River.
USO DE ANTICORPOS MONOCLONAIS POR PACIENTES COM COVID-19 INTERFERE NA CONCENTRAÇÃO SÉRICA DE ANGIOTENSINA II?
Authors: Fernandes Paiva Daniel Felipe 
Published: November 2022

Introdução: uma vez conhecidos os mecanismos de patogênese do Sars-Cov-2, vários métodos de tratamento para a COVID-19 foram desenvolvidos, dentre eles destaca-se o uso dos anticorpos monoclonais para o contexto de pacientes em estágios graves da doença. Objetivo: compreender se o uso dos anticorpos monoclonais para tratamento da COVID-19 grave interfere nos níveis séricos da angiotensina II. Metodologia: Para a realização dessa pesquisa foram selecionados através do DeCS e MeSH os descritores “COVID-19”, “Angiotensin II” e “Antibodies, Monoclonal” e seus respectivos “entry terms” sugeridos pela base MeSH. Posteriormente,utilizando-se os operadores booleanos OR e AND, foi montada uma estratégia de busca, a qual foi utilizada nas bases de dados PUBMED, EMBASE, Web of Science, Cochrane Library e Scopus, sem restrição de data de publicação ou idioma. Resultados: ao final do processo de seleção dos artigos, 29 foram selecionados para a leitura e análise completa. Nesta revisão, foram abordados diferentes tipos de anticorpos monoclonais, os quais foram oportunamente agrupados de acordo com o seu mecanismo de ação. Conclusão: foi possível concluir que das cinco classes de anticorpos monoclonais tratadas neste trabalho, três potencialmente podem causar alterações nos níveis séricos de angiotensina II.
PERFIL EPIDEMIOLÓGICO DOS PACIENTES HOSPITALIZADOS COM COVID-19 NO MUNICÍPIO DE MOSSORÓ-RN
Authors: Gomes Farias Ariadne , Araújo Cunegundes de Brito Andiara , Do Vale e Silva Jennifer , Taborda Ribas da Cunha Andrea , Maciel de Queiroz Janaina , Oliveira Reis de Freitas Kalidyjamayra , Elizabeth Lopez Carrillo Sonia , Miyoshi Sakamoto Sidnei , De Moraes Maiara 
Published: November 2022

Introdução: Assim como observado no cenário nacional, o município de Mossoró apresentou altas taxas de letalidade nos primeiros meses de pandemia. Todavia, o conhecimento epidemiológico em torno da Covid-19 no município tem ocorrido, sobretudo, através de documentos institucionais das Secretarias de Saúde. Desse modo, a finalidade deste estudo é fornecer evidências que permitam ampliar a compreensão da ocorrência da doença em nível local, ofertar dados e informações que venham a subsidiar as políticas públicas de saúde municipais e gerar hipóteses sobre a morbimortalidade da doença para futuras investigações científicas. Objetivo: Analisar o perfil epidemiológico dos casos internados e confirmados de Covid-19 no município de Mossoró no estado do Rio Grande do Norte/Brasil. Metodologia: Estudo observacional transversal, baseado em dados secundários de casos internados de Covid-19 registrados no Sistema Único de Saúde entre março e outubro de 2020. Resultados: Foram incluídos na amostra 664 pacientes, dos quais 46,5% evoluíram para óbito. Entre as internações, 63,1% resultaram em internações em unidades de terapia intensiva (UTI). Observamos diferenças estatísticas significativas entre 'admissão na UTI e evolução para óbito' e 'faixa etária e evolução para óbito' e, maior risco entre idosos acima de 60 anos, com comorbidades, dispneia e saturação de O2 <95%. A necessidade de suporte ventilatório invasivo foi considerada fator predisponente para óbito. O risco de internação na UTI foi maior entre as idosas. Conclusões: A hospitalização e o óbito de pacientes com COVID-19 foram maiores em pacientes idosos com comorbidades.
Palavras-Chave: COVID-19; infecção por coronavírus; Epidemiologia; pandemia; Brasil.
PERDA DENTÁRIA E SUAS CONSEQUÊNCIAS PSICOSSOCIAIS EM ADULTOS E IDOSOS
Authors: Andrade Bruno Vidal , Carvalho Fábio Silva de , Alves Paz de Carvalho Cristiane 
Published: November 2022

Introdução: É notório que a perda dentária é um obstáculo a ser lidado na saúde bucal, sendo ainda considerado um problema de saúde pública no Brasil que gera consequências físicas e psicológicas principalmente para adultos e idosos. Objetivo: Descrever as principais consequências psicossociais ocasionadas pela perda dentária em adultos e idosos. Metodologia: Trata-se de uma revisão integrativa da literatura, em que foram realizadas buscas bibliográficas eletrônicas com intervalo de tempo de publicação de seis anos (2016 - 2022) nas bases de dados Biblioteca Virtual em Saúde (BVS) e Scientific Electronic Library Online (SciELO). Foram usados os descritores Perda de Dente, Saúde Bucal, Impacto Psicossocial, Adulto e Idoso com o auxílio do operador booleano “and”, sendo contemplados artigos em português e inglês no qual o título, o resumo e a leitura na íntegra se relacionassem com o tema, e excluídas publicações do tipo monografias, dissertações, teses, capítulos de livros, livros na íntegra e artigos que não abordaram o tema de estudo. Resultados: Foram utilizados 14 artigos no total para compor o referencial teórico da revisão, sendo que todas essas publicações trouxeram informações relevantes quando se associa a perda dentária com o impacto psicossocial no público alvo. Conclusão: A perda dentária abala a qualidade de vida das pessoas. Fatores psicológicos como a timidez, a vergonha e alteração de rotinas influenciam na vida social de adultos e idosos.
Palavras-Chave: Perda de Dente; Saúde Bucal; Impacto Psicossocial; Adulto; Idoso.
Estimate Final Cost of Roads Using Support Vector Machine
Authors: Hasan Musaab Falih , Hammody Oday , Albayati Khaldoon Satea 
Published: November 2022

Introduction:
The cost overrun in road construction projects in Iraq is one of the major problems that face the construction of new roads.

Method:
To enable the concerned government agencies to predict the final cost of roads, the objective this paper suggested is to develop an early cost estimating model for road projects using a support vector machine based on (43) sets of bills of quantity collected in Baghdad city in Iraq. As cost estimates are required at the early stages of a project, consideration was given to the fact that the input data for the support vector machine model could be easily extracted from sketches or the project's scope definition.

Result:

The data were collected from contracts awarded by the Mayoralty of Baghdad for completed projects between 2010-2013. Mathematical equations were constructed using the Support Vector Machine Algorithm (SMO) technique.

Conclusion
An average of accuracy (AA) (99.65%) and coefficient of determination (R2) (97.63%) for the model were achieved by the created prediction equations.
Research on Shrinkage and Shrinkage Models of Reinforced Concrete Specimens
Authors: Zhang Guilin , Chen Pang , Si Xiaoyu , Wang Jingde , Han Yang 
Published: November 2022

Introduction:
It is very important to accurately predict the shrinkage of reinforced concrete specimens to ensure structural safety.

Methods:
In this study, a total of 36 reinforced concrete specimens were used with a size of 150mm×150mm×450mm to examine concrete strength grades and longitudinal reinforcement ratios on the shrinkage of reinforced concrete specimens using shrinkage tests.

Results:
The results showed that the concrete strength increased from 35MPa to 58.2MPa, and the shrinkage rate of concrete decreased by about 30%. The ratio of reinforcement increased from 0 to 2.01%, and the shrinkage rate of concrete decreased by about 40%.

Conclusion:
The experimental results were compared with existing shrinkage models of reinforced concrete, and a modified shrinkage calculation model of reinforced concrete was proposed.
Interaction of Lysosomes and Calpain on Neurofilament Steady-state Levels
Authors: Vohnoutka Rishel Brenna , Myre Michael , Sargent Ava , Shea Thomas B. 
Published: November 2022

Abstract

Background:
An imbalance of protease activity can foster the aberrant accumulation of phosphorylated neurofilaments (NF) within perikarya resembling human neuropathological conditions.

Objective:
We examined whether or not the inhibition of the lysosomal system increased NF levels.
Method: Differentiated NB2a/d1 cells were transfected with GFP-tagged NF-heavy and treated with chlorquine (active against autophagy) and/or a calpain inhibitor. Additional cells were transfected with the cyclin-dependent kinase 5 activator p35.

Results:
Unexpectedly, chloroquine decreased NF levels, which was prevented by the simultaneous treatment with the calpain inhibitor or expression of p35.

Discussion:
These findings suggest that compensatory increases in calpain activity can accompany inhibition of autophagy. This reduction was also prevented by the expression of the cdk5 activator p35, consistent with the resistance of extensively phosphorylated NF-H to proteolysis by calpain.

Conclusion:
These findings highlight the complex interplay among kinase, phosphatase, and protease systems in neuropathology.
Effect of Folic Acid Conjugated Silver Nanoparticles in Treatment of RA Like Adjuvant Arthritis in Rats
Authors: Ahmed Hajar K. , Elbeialy Adel A. , Mansour Ahmed M. , El-Zomor Hala M. , Abosaif Amany I. 
Published: November 2022

Objective:
Nano medicine has become one of the promising research areas, opening new horizons in disease diagnosis and treatment. Recent years have witnessed a surge in the development of Nano medicine for combating rheumatoid arthritis (RA), the most common autoimmune arthritis. RA is characterized by progressive inflammation and persistent synovitis, leading to joint destruction, functional incapability, and ultimately disability. Although there has been a tremendous evolution in disease assessment and treatment, many patients still fail to attain remission. Therefore, developing new drugs that specifically target inflamed joints and simultaneously attenuate other possible damages to healthy tissues is indispensable. This study was done to evaluate the potential of folic acid conjugated silver nanoparticles (FA-AgNPs) as RA therapy.

Methods:
In the CFA-arthritic rat model, FA-AgNPs & methotrexate were administered for 8 consecutive weeks. Therapeutic efficacy was evaluated by measuring paw volume, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumor necrosis factor (TNF-α), and interleukin-6 (IL-6) levels. For safety concerns, complete blood picture (CBC), liver and renal function tests were evaluated. Joints histological assessment was also carried out.

Results:
FA-AgNPs significantly reduced paw volume, paw weight, ESR, CRP, RF, TNF-α, and IL-6 levels compared with arthritic non-treated rats, demonstrating good anti-inflammatory activity. Likewise, histology of tarsal joints depicted comparatively lesser inflammatory cellular infiltration and diminished cartilage erosions. Methotrexate displayed comparable results. In contrast to methotrexate, FA-AgNPs showed normal CBC & significantly improved liver and renal function tests.

Conclusion:
FA-AgNPs exhibited substantial anti-arthritic activity. This notable anti-arthritic potential of FA-AgNPs was as good as the current standard treatment of methotrexate (MTX) with higher biosafety.
The Pattern of Pediatric Acute Respiratory Distress Syndrome over 10 Years Period and Related Risk Factors of its Outcome Mortality
Authors: Albuali Waleed H. , Alghamdi Amal 
Published: November 2022

Background:
Although paediatric acute respiratory distress syndrome (PARDS) is a common and devastating clinical syndrome that contributes to high morbidity and mortality, there is little known about its pattern and outcome mortality over time.

Objective:
This study aimed to determine the pattern of PARDS over a 10-year period and the risk factors for its outcome, mortality.

Methods:
This study was done at King Fahd University Hospital in Saudi Arabia using a retrospective study design involving children aged from > 2 weeks to 14 years admitted to the PICU due to PARDS. Over the last ten years, data was extracted from their medical records.

Results:
The number of PICU admissions over the last ten years was 2317, the rate of PARDS amongst PICU admissions was 376/2317 (16.23%), and mortality amongst PARDS cases was 83/376 (22.07%). ER admission route, chronic liver disease, sepsis, fluid overload, the number of inotropes 3, and pneumonia mediastinum were significant predictors of mortality in PARDS (p 0.001). In addition, the mean PRISM III score, PICU admission days, and ventilation days were higher in the deceased than in the survivors of PARDS. In contrast, the mean PaO2/FIO2 and oxygen saturation indices were significantly lower among the deceased than the survivors (p 0.01).

Conclusion:
Although the rate of PARDS was alarming, the number of PARDS deaths was constant over the study period. Sepsis, ER admission route, comorbidities, fluid overload, a higher PRISM III score, longer PICU admission, and ventilation days increased the risk of PARDS mortality.
Differences in Bone Mineral Density Values in Postmenopausal Women with Fracture and Non-Fracture
Authors: Suryana Bagus Putu Putra , Tarigan Ricky Cornelius , C J Huwae Thomas Erwin 
Published: November 2022

Background: Osteoporosis is an increasing health problem in Indonesia. Fractures that occur in the spine and pelvis are considered to be the most common fracture sites for osteoporosis.
Aim: to determine the differences in bone mineral density values in postmenopausal women with fracture and non-fracture.
Methods: Survey was carried out in postmenopausal female patients with fractures and without fractures who were included in the inclusion criteria with a case-control study approach and had bone mass density data. For the group of cases with fracture, the amount of vertebral compression was measured using Gennant's measurement criteria. Interviews were conducted regarding the characteristics of patients with and without fracture. The differences in BMD values ​​were analyzed in postmenpausal female patients with fracture and without fracture by using unpaired T test on normal data distribution and Mann-Whitney test on abnormal data distribution. The measured BMD value is the T-score. The analysis result was considered significant if p <0.05.
Results: There was a significant difference between L4 BMD (p = 0.029) and femoral neck BMD (p = 0.014) in postmenopausal female patients with fracture and without fracture. However, there were no significant differences for other BMD regions (p> 0.5).
Conclusion: BMD L4 and femoral neck values ​​differ significantly in female patients with postmenopausal osteopenia with fracture and non-fracture.
Psychometric Properties of the Chinese Warwick-Edinburgh Mental Well-being Scale in Medical Staff: Cross-sectional Study
Authors: Dong Aishu , Huang Jing , Lin Shudan , Zhu Jianing , Zhou Haitao , Jin Qianqian , Zhao Wei , Zhu Lianlian , Guo Wenjian 
Published: November 2022

Background
Worldwide, mental well-being is a critical issue for public health, especially among medical staff; it affects professionalism, efficiency, quality of care delivery, and overall quality of life. Nevertheless, assessing mental well-being is a complex problem.

Objective
This study aimed to evaluate the psychometric properties of the Chinese-language version of the 14-item Warwick-Edinburgh Mental Well-being Scale (WEMWBS) in medical staff recruited mainly from 6 hospitals in China and provide a reliable measurement of positive mental well-being.

Methods
A cross-sectional online survey was conducted of medical staff from 15 provinces in China from May 15 to July 15, 2020. Confirmatory factor analysis (CFA) was conducted to test the structure of the Chinese WEMWBS. The Spearman correlations of the Chinese WEMWBS with the 5-item World Health Organization Well-Being Index (WHO-5) were used to evaluate convergent validity. The Cronbach α and split-half reliability (λ) represented internal consistency. A graded response model was adopted for an item response theory (IRT) analysis. We report discrimination, difficulty, item characteristic curves (ICCs), and item information curves (IICs). ICCs and IICs were used to estimate reliability and validity based on the IRT analysis.

Results
A total of 572 participants from 15 provinces in China finished the Chinese WEMWBS. The CFA showed that the 1D model was satisfactory and internal consistency reliability was excellent, with α=.965 and λ=0.947, while the item-scale correlation coefficients ranged from r=0.727 to r=0.900. The correlation coefficient between the Chinese WEMWBS and the WHO-5 was significant, at r=0.746. The average variance extraction value was 0.656, and the composite reliability value was 0.964, with good aggregation validity. The discrimination of the Chinese WEMWBS items ranged from 2.026 to 5.098. The ICCs illustrated that the orders of the category thresholds for the 14 items were satisfactory.

Conclusions
The Chinese WEMWBS showed good psychometric properties and can measure well-being in medical staff.
Crisis, funcionalidad y tipología familiar en pacientes con cáncer de mama
Authors: Soto-Araujo Pamela , Salazar-Orozco Fernanda , Ramírez-Leyva Diego H. , Valle-Iribe Canek , Medina-Serrano Julio M. , Flores-Lujano Janet 
Published: November 2022

Objetivo: describir la crisis, funcionalidad y tipología familiar en pacientes con cáncer de mama. Métodos: estudio transversal analítico, se realizó entre agosto y diciembre de 2021. La muestra fue de 250 pacientes con cáncer de mama que cumplieron los criterios de selección. La presencia de crisis familiares se determinó con el test de Holmes-Rahe. La funcionalidad familiar se valoró con la Escala de Evaluación de Adaptabilidad y Cohesión Familiar iii. La tipología familiar se determinó con base en su conformación. Realizamos estadística descriptiva e inferencial. Para el análisis bivariado se utilizó razón de momios, χ2 de Pearson y U de Mann-Whitney con intervalos de confianza de 95% (p<0.05). Resultados: la frecuencia de crisis en pacientes con cáncer de mama fue de 89% (enfermedad personal, cambios en los hábitos de sueño, alimentación y condiciones familiares), las familias disfuncionales se presentaron en 58% y la tipología familiar más frecuente fue nuclear (63%). Conclusión: un alto porcentaje de pacientes con cáncer de mama tienen crisis familiares, las cuales se generaron durante el proceso de la enfermedad.
STRATEGI PENGEMBANGAN USAHA UMKM DALAM MENINGKATKAN LABA USAHA PADA ERA PANDEMI COVID-19 PADA USAHA KERIPIK TEMPE “MBAK NIK” DI MERANGIN
Authors: Ariana Alinda Putri , Ekasari Novita 
Published: November 2022

ABSTRAK
Penelitian ini bertujuan untuk untuk mengidentifikasi kekuatan, kelemahan, peluang dan ancaman usaha Keripik Tempe Mbak Nik di Merangin dan untuk merumuskan Strategi Pengembangan usaha Keripik Tempe Mbak Nik di Merangin. Penelitian ini dilakukan melalui beberapa tahapan, yaitu tahap identifikasi lingkungan internal dan eksternal usaha. Identifikasi lingkungan internal dilakukan pada analisis Kekuatan dan Kelemahan. Sedangkan lingkungan eksternal yang dianalisis adalah lingkungan Peluang dan Ancaman. Tahap selanjutnya adalah tahap pencocokan dengan menggunakan matriks IE dan matriks SWOT. Berdasarkan hasil analisis SWOT pada usaha Keripik Tempe Mbak Nik di Merangin, maka rekomendasi strategi yang direkomendasikan adalah agresif (Growth oriented strategy). Artinya, situasi yang sangat menguntungkan perusahaan tersebut memiliki peluang dan kekuatan sehingga dapat memanfaatkan peluang yang ada. Usaha ini harus memanfaatkan peluang yang ada untuk memenuhi permintaan pasar yang tinggi dengan memanfaatkan pinjaman modal dari pihak perbankan atau koperasi karena untuk strategi agresif usaha Keripik Tempe Mbak Nik harus melakukan penetrasi pasar baru diluar Merangin. Sehingga, usaha Keripik Tempe Mbak Nik sebaiknya menambah kapasitas produksinya agar bisa memperluas pasar.

Kata kunci : Strategi Pengembangan, Keripik, SWOT
PENGARUH CR, DER, NPM, DAN PER TERHADAP RETURN SAHAM PADA PERUSAHAAN SEKTOR PROPERTY AND REAL ESTATE YANG TERDAFTAR DI BEI PERIODE 2015-2019
Authors: Gulo Dorifati , Januardin Januardin 
Published: November 2022

Return saham yaitu pendapatan saham saham karena selisih antara harga saham saat ini dengan harga saham sebelumnya. Perusahaan harus mampu membuat kebijakan menyangkut Current Ratio (CR), Debt to Equity Ratio (DER), Net Profit Margin (NPM), dan Price Earning Ratio (PER) terhadap return saham berkaitan dengan kemungkinan menarik investor untuk berinvestasi. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh Current Ratio (CR), Debt to Equity Ratio (DER), Net Profit Margin (NPM), dan Price Earning Ratio (PER) terhadap Return Saham Pada Perusahaan Property and Real Estate yang Terdaftar di Bursa Efek Indonesia Periode 2015-2019. Populasi penelitian dalam penelitian ini adalah 44 perusahaan dengan teknik pengambilan Purposive Sampling sebanyak 20 perusahaan pada sektor property and real estate di bursa efek Indonesia tahun 2015-2019. Metode penelitian yang digunakan dalam penelitian ini menggunakan metode Kuantitatif, jenis penelitian deskriptif, sifat penelitian deduktif, teknik pengumpulan data tinjauan pustaka dan dokumentasi. Metode pengujian menggunakan uji asumsi klasik yaitu Analisis Regresi Linier Berganda. Hasil penelitian secara simultan Current Ratio (CR), Debt to Equity Ratio (DER), Net Profit Margin (NPM), dan Price Earning Ratio (PER) secara bersama-sama berpengaruh positif signifikan terhadap Return Saham. Secara parsial, Current Ratio (CR), Net Profit Margin (NPM), dan Price Earning Ratio (PER) berpengaruh positif signifikan terhadap Return Saham, sedangkan Debt to Equity Ratio (DER) tidak berpengaruh signifikan terhadap Return Saham.

Kata Kunci: Current Ratio (CR), Debt to Equity Ratio (DER), Net Profit Margin (NPM), dan Price Earning Ratio (PER), Return Saham