bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH INJEKSI NAPHTA OFF TERHADAP CATALYTIC NAPHTA DI REGENERATOR-REAKTOR RFCCU (RESIDUAL FLUIDIZED CATALYTIC CRACKING UNIT)
Authors: Cristina Mery , Zamrudy Windi , Mufti Hery A. 
Published: September 2022

Naphta off di CDU (Crude Distillation Unit) VI PT. Pertamina RU III Plaju-Palembang mengalami penumpukan, sehingga perlu adanya pengolahan kembali untuk meningkatkan nilai jualnya. PT. Pertamina RU III Plaju Palembang berusaha untuk mengelola produk yang tidak memenuhi spesifikasi atau memiliki nilai jual rendah menjadi produk yang memiliki nilai jual tinggi. Salah satu cara yang dapat diterapkan adalah memanfaatkan naphta off sebagai bahan injeksi di MTC (Mixed Temperature Control) yang merupakan bagian dari RFCCU (Residiual Fluidized Catalytic Cracking Unit). Tujuan penelitian ini adalah untuk mengetahui pengaruh laju alir injeksi naphta off terhadap %yield dan Octane Number (ON) produk catalytic naphta di RFCCU (Residual Fluidizied Catalytic Cracking Unit), serta melakukan perhitungan kebutuhan panas dari regenerator-reaktor pada kondisi %yield dan ON catalytic naphta optimum. Variabel bebas yang digunakan adalah laju alir injeksi naphta off, yakni 0; 24,42; 89,73; 96,13; 96,46; 97,1; 101,19 (Ton/Day). Dari hasil penelitian diketahui, semakin banyak laju alir naphta off yang diijeksikan, maka %yield catalytic naphta cenderung meningkat, namun pengaruhnya pada ON mengalami penurunan. % Yield catalytic naphta tertinggi (54,51%) diperoleh pada laju alir 97,1 T/D. Pada laju alir naphta off tersebut juga menghasilkan ON catalytic naphta sebesar 91, yang masih memenuhi batas minimal standar Pertamina RU III (≥ 91). Kondisi operasi yang dibutuhkan untuk menghasilkan produk catalytic naphta optimal %yield (54,51 %) dan ON (91) adalah pada suhu reaktor 502,36°C dan suhu regenerator 661°C, dengan kebutuhan panas regenerator-reaktor sebesar 470,38 BTU/lb feed.
STUDI LITERATUR PENGARUH AKTIVASI FISIKA DAN KIMIA TERHADAP KUALITAS KARBON AKTIF DARI LIMBAH PERTANIAN DAN PERKEBUNAN
Authors: Listyorini Handini , Lestari Diyah Indriya , Zamrudy Windi 
Published: September 2022

Kebutuhan karbon aktif di Indonesia semakin meningkat. Hal ini dilatarbelakangi oleh semakin banyaknya aplikasi karbon aktif pada industri sebagai adsorben. Oleh karena itu, diperlukan produksi dan penelitian dalam pembuatan karbon aktif. Studi literatur ini bertujuan untuk mengetahui pengaruh aktivasi fisika dan kimia pada karbon aktif serta analisis karakteristik karbon aktif dari limbah pertanian dan perkebunan, seperti tempurung kelapa, tempurung kemiri, kulit durian, kulit singkong, dll. Metode yang digunakan berupa analisis deskriptif kualitatif dengan menganalisis variabel bebas berupa suhu karbonisasi 300-8000C, aktivator, dan bahan dasar limbah. Proses yang digunakan terdiri atas dua yaitu karbonisasi dan aktivasi. Proses aktivasi fisika menggunakan gas antara lain H2O, O2, N2, sedangkan pada aktivasi kimia menggunakan bahan kimia : KOH, H3PO4, HCl, ZnCl2, CaCl2. Hasil studi menunjukkan bahwa didapatkan daya serap iodium terbaik dengan aktivasi kimia menggunakan aktivator H3PO4 dari kulit singkong diperoleh hasil 2.537,71 mg/g. Aktivator H3PO4 berperan penting terhadap karakteristik karbon aktif karena dapat menyerap kandungan mineral pada bahan yang akan dijadikan karbon aktif. Daya serap iodium ini dijadikan acuan karena mempengaruhi kualitas karbon aktif. Tingginya bilangan iod akan menghasilkan pori-pori yang banyak, sehingga daya adsorpsi yang dihasilkan juga semakin besar. Hasil tersebut telah memenuhi SNI 06-3730-1995.
ANALISIS ALAT DEFEKATOR PADA STASIUN PEMURNIAN PABRIK GULA JATIROTO DENGAN KAPASITAS GILING 7000 TCD
Authors: Putri Farida Destiara Harinda , Maryanty Yanty , Widodo Arwan Agustulus 
Published: September 2022

Pabrik Gula Jatiroto merupakan salah pabrik gula penghasil gula kristal putih dengan kapasitas giling 7000 TCD (Ton Cane per Day). Kualitas produk gula yang dihasilkan yaitu harus memenuhi standar yang mengacu pada SNI yang dikeluarkan oleh BSN. Salah satu faktor keberhasilan untuk mencapai kualitas gula yang baik dengan mengendalikan pembentukan gula reduksi pada alat defekator di stasiun pemurnian dengan acuan pada waktu tinggal. Saat ini alat defekator yang terpasang pada Pabrik Gula Jatiroto memiliki waktu tinggal kurang dari 1 menit yaitu 0,77 menit yang tergolong sudah baik. Akan tetapi sempat terjadi pembentukan gula reduksi sehingga, perlu dilakukan pembaharuan analisis perhitungan alat defekator. Tujuan dari penelitian ini yaitu untuk menganalisis waktu tinggal dan kebutuhan penguat alat defekator yang terpasang pada Pabrik Gula Jatiroto sudah sesuai standard industri. Alat defekator dianalisis dengan melakukan perhitungan manual dengan Microsof excel dengan memperhatikan beberapa parameter yang berpengaruh pada waktu tinggal alat defekator antara lain, tinggi total bejana (H), diameter bejana (Dt), dan diameter impeller (Da). Hasil perhitungan didapatkan nilai tinggi total bejana (H) yaitu 10,47 ft , diameter bejana (Dt) yaitu 71,06 inci, diameter impeller (Da) 23,45 inci, dan waktu tinggal 0,44 menit. Berdasarkan hasil perhitungan waktu tinggal dan kebutuhan penguat alat defekator dapat dianggap baik dan alat defekator tidak memerlukan penguat.
PERANCANGAN REAKTOR PADA PROSES PEMBUATAN DISPROPORTIONATED ROSIN DARI GUM ROSIN MELALUI NETRALISASI ASAM KLORIDA
Authors: Amalia Amanda Dewi , Chumaidi Achmad 
Published: September 2022

Kawasan hutan di Indonesia memiliki keanekaragaman hayati yang melimpah. Salah satu jenis tanaman hutan adalah pohon pinus. Pohon pinus dimanfaatkan getahnya untuk diolah menjadi berbagai macam produk, seperti gondorukem dan terpentin serta turunannya. Disproportionated rosin merupakan salah satu produk turunan dari gondorukem, biasanya digunakan sebagai bahan tambahan dalam produksi karet sintetis, ban, hingga cat dinding. Proses pembuatan disproportionated rosin melalui reaksi pelarutan gum rosin dengan etanol, reaksi penambahan larutan HCl 37%, dan reaksi pembentukan produk Na-abietik di dalam reaktor berpengaduk. Tujuan perancangan alat ini adalah merancang reaktor untuk proses disproporsionasi dalam pembuatan disproportionated rosin. Perancangan dilakukan dengan menentukan jenis reaktor, jenis material, dan dimensi reaktor. Hasil dari perancangan menunjukkan reaktor yang digunakan adalah reaktor berpengaduk berdiameter 2,7337 m dan tinggi 5,0404 m. Bentuk tutup atas dan tutup bawah dari reaktor berbentuk standard dished head dan jenis material dari reaktor yaitu Stainless steel SA-167 Grade 3 Type 304.
PEMANFAATAN LUMPUR LAPINDO SEBAGAI ADSORBEN TERHADAP PENURUNAN KADAR MANGAN PADA AIR TANAH
Authors: Dewantara Damar Pietradagya , Hutabarat Dicky Morina , Sudarminto Hadi Priyo 
Published: September 2022

Air tanah merupakan sumber persediaan air yang penting bagi keberlangsungan kehidupan manusia salah satunya yaitu digunakan sebagai konsumsi air minum. Air minum adalah air yang melalui proses pengolahan atau tanpa proses pengolahan yang memenuhi syarat kesehatan dan dapat langsung diminum. Pembuangan lumpur lapindo menimbulkan dampak terhadap kualitas air tanah dimana salah satunya menimbulkan kenaikan kadar mangan. Hal ini sangat memprihatinkan karena kadar mangan (Mn) pada air tanah yang tinggi dapat menyebabkan masalah kesehatan jika dikonsumsi sebagai air minum. Adapun tujuan penelitian yang dilakukan yaitu memanfaatkan lumpur lapindo sebagai adsorben untuk menurunkan Kadar Mn, sehingga dapat memenuhi standard mutu. Pada peneletian ini digunakan variabel massa lumpur lapindo sebanyak 40, 60, 80 gram dengan waktu pengadukan selama 60, 80,dan 100 menit menggunakan metode adsorpsi batch dengan kecepatan pengadukan sebesar 200 rpm. Hasil Penelitian menunjukkan banyaknya massa adsorben lumpur lapindo berpengaruh terhadap penurunan logam mangan yang ada. Semakin tinggi massa adsorben lumpur lapindo yang digunakan daya adsorpsi untuk menjerap logam Mn semakin menurun. Hasil terbaik ditunjukkan oleh sampel 3 (massa adsorben lumpur lapindo 40 gram dengan lama pengadukan 100 menit) dengan daya serap 80%.
PENGARUH JENIS CAMPURAN BATUBARA TERHADAP KEBUTUHAN ALKALI AIR LAUT DALAM MENYERAP GAS SO2 HASIL PEMBAKARAN BATUBARA DI PT PAITON OPERATION AND MAINTENANCE INDONESIA
Authors: Romadhona Gerda Safira , Kautsarrany Rizqina , Ariani Ariani , Yulianto Erwan 
Published: September 2022

Menipisnya jumlah batubara dari sumber yang lama, yaitu Adaro dan Kideco, membuat PT POMI saat ini melakukan pencampuran dengan sumber yang baru, diantaranya Baramulti, Jembayan, danTitan. Namun, dari jenis batubara baru memiliki kandungan sulfur yang lebih tinggi sehingga meningkatkan potensi pencemaran udara apabila gasSO2 hasil pembakaran tidak terserap sepenuhnya oleh air laut. Perlu dilakukan penelitian terhadap pengaruh total sulfur dalam campuran batubara terhadap air laut dalam menyerap gas hasil pembakaran dan perkiraan kebutuhan alkali air laut dalam menyerap gas SO2 berdasarkan kadar SO42-. Penelitian melibatkan proses pembakaran 50 gram batubara dan penyerapan gas hasil pembakaran oleh 500 mL air laut menggunakan sistem batch. Rasio campuran batubara sejumlah 4:2 dengan variasi campuran, yaitu Adaro:Baramulti, Adaro:Jembayan, Adaro:Titan, Kideco:Baramulti, Kideco: Jembayan, dan Kideco:Titan. Dari hasil penelitian diperoleh bahwa Kideco:Titan (4:2) dengan total sulfur sebesar 0,163% memberi pengaruh terbesar terhadap keterserapan gas SO2 oleh air laut dengan penurunanpH dan alkalinitas paling banyak, serta kadar SO42- paling tinggi. Kebutuhan alkali air laut dalam menyerap gas SO2 yang paling tinggi untuk pembakaran batubara Adaro:Baramulti (4:2) sebesar 0,125 gram.
PENGARUH PENAMBAHAN AIR IMBIBISI TERHADAP KEHILANGAN GULA DALAM AMPAS DI PABRIK GULA LESTARI
Authors: Jayanti Meda Dwi , Budiono Arief , Junet Antonius 
Published: September 2022

Gula merupakan salah satu bahan pokok yang banyak digunakan oleh masyarakat indonesia. Pabrik Gula Lestari merupakan unit usaha PT Perkebunan Nusantara X yang menghasilkan produk utama berupa gula GKP (Gula Kristal Putih). Proses produksi gula dilakukan beberapa tahapan yaitu, penimbangan tebu, penggilingan tebu, pemurnian nira, penguapan, kristalisasi, pemisahan kristal dan pengemasan. Pada proses penggilingan tebu terdapat kehilangan gula dalam ampas, untuk mengurangi kehilangan ini maka ditambahkan air imbibisi. Tujuan dari penelitian ini adalah mengetahui pengaruh penambahan air imbibisi terhadap kehilangan gula dalam ampas. Metode penelitian yang digunakan adalah eksperimental. Variasi penambahan air imbibisi yaitu 28 -31% dari berat tebu yang digiling. Dari variasi penambahan air imbibisi tersebut, ampas tebu gilingan terakhir dianalisis menggunakan polarimeter. Hasil penelitian menunjukkan nilai pol ampas yang sesuai yaitu ≤ 2%, terjadi pada penambahan air imbibisi 30,15 – 31,36%.
Cuprotosis-related signature predicts overall survival in clear cell renal cell carcinoma
Authors: Zhang Fan , Lin Junyu , Feng Dechao , Liang Jiayu , Lu Yiping , Liu Zhihong , Wang Xianding 
Published: September 2022

Background: Cuprotosis is a new form of programmed cell death induced by copper. We explored the correlation of cuprotosis with clear cell renal cell carcinoma (ccRCC) and constructed a cuprotosis-related signature to predict the prognosis of patients with ccRCC.Methods: The clinical and transcriptomic data of ccRCC patients were downloaded from The Cancer Genome Atlas (TCGA), cBioPortal, and GEO databases, and cuprotosis-related gene sets were contained in the previous study. A cuprotosis-related signature was developed based on data from TCGA and verified by data from cBioPortal and GEO databases. The immune cell infiltrates and the corresponding signature risk scores were investigated. Two independent cohorts of clinical trials were analyzed to explore the correlation of the signature risk score with immune therapy response.Results: A signature containing six cuprotosis-related genes was identified and can accurately predict the prognosis of ccRCC patients. Patients with downregulated copper-induced programmed death had a worse overall survival (hazard ratio: 1.90, 95% CI: 1.39–2.59, p &lt; 0.001). The higher signature risk score was significantly associated with male gender (p = 0.026), higher tumor stage (p &lt; 0.001), and higher histological grade (p &lt; 0.001). Furthermore, the signature risk score was positively correlated with the infiltration of B cells, CD8+ T cells, NK cells, Tregs, and T cells, whereas it was negatively correlated with eosinophils, mast cells, and neutrophils. However, no correlation between cuprotosis and response to anti-PD-1 therapy was found.Conclusion: We established a cuprotosis signature, which can predict the prognosis of patients with ccRCC. Cuprotosis was significantly correlated with immune cell infiltrates in ccRCC.
Catheter ablation in patients with ventricular fibrillation by purkinje de-networking
Authors: Sciacca Vanessa , Fink Thomas , Guckel Denise , El Hamriti Mustapha , Khalaph Moneeb , Braun Martin , Sohns Christian , Sommer Philipp , Imnadze Guram 
Published: September 2022

BackgroundVentricular fibrillation (VF) is a leading cause of cardiovascular death worldwide. However, recurrence rates of arrhythmia are high leading to mortality and morbidity. Recently, Purkinje fibers have been identified as potential sources of VF initiation and maintenance.AimThe study analyzes the feasibility and effectiveness of catheter ablation in patients with recurrent VF by specific Purkinje de-networking (PDN).MethodsConsecutive patients with recurrent VF undergoing PDN were included in this observational study. The procedural endpoint was the non-inducibility of sustained ventricular arrhythmia. A three-dimensional -anatomical mapping was conducted, and the specific cardiac conduction system and Purkinje fibers were tagged. All detectable Purkinje signals were ablated in the left ventricle (LV). Additional right ventricular (RV) PDN was performed in case of VF inducibility after LV ablation. Follow-up was performed by patient visits at our outpatient clinic including device interrogation and by telephone interviews.ResultsEight patients were included in the study. Six patients were females (75%); the median age during the procedure was 43 [37;57] years and the median body mass index was 24 [23;33] kg/m2. Four patients (50%) had known structural heart disease with two cases of ischemic cardiomyopathy and two cases of dilated cardiomyopathy. In four patients (50%), no underlying structural heart disease could be identified. The median LV ejection fraction was 42 ± 16.4%. All patients had an implantable cardioverter-defibrillator (ICD) prior to ablation with documentation of recurrent VF. The median number of ICD shocks before the ablation was 5 [3;7]. LV PDN was performed in all patients. In two patients (25%), an additional RV PDN was performed. Non-inducibility of any ventricular arrhythmia was achieved in all patients after PDN. Two patients showed complete left bundle branch block post-ablation. The median follow-up duration was 264 [58;421] days. Two patients (25%) experienced ventricular arrhythmia recurrence with recurrent ICD-shock delivery. One patient died during follow-up with an unknown cause of death. Six patients (75%) experienced no arrhythmia recurrence during follow-up.ConclusionPurkinje de-networking represents a novel treatment option for patients with recurrent VF without arrhythmia substrate or specific arrhythmia triggers with promising results in terms of efficiency and feasibility. Larger and more prospective studies are needed for a systematic evaluation.
Optimal waiting period for frozen embryo transfer after hysteroscopic polypectomy: A propensity score matching analysis
Authors: Wang Bijun , Meng Nan , Zhang Wenjuan , Kong Pingping , Liu Zhaozhao , Liu Wenxia , Sun Huaqing , Zhang Wen , Ren Chenchen , Guan Yichun 
Published: September 2022

ObjectiveTo evaluate the optimal waiting period for frozen-thawed embryo transfer (FET) after hysteroscopic polypectomy (HSC-P).DesignRetrospective cohort.SettingUniversity-affiliated hospital.Patient(s)All patients included in this research underwent hysteroscopy before the first FET cycle after whole embryo freezing. A total of 206 patients had undergone HSC-P, and 3681 patients without endometrial polyps were defined as the controls.Intervention(s)HSC-P.Main outcome measure(s)The HSC-P group was divided into three subgroups based on the time interval between HSC-P and the start of an FET cycle. Subgroup 1 consisted of patients who underwent FET after their next menses, subgroup 2 after two menstrual cycles, and subgroup 3 after three or more menstrual cycles. Demographics, baseline in vitro fertilization (IVF) characteristics, and pregnancy outcomes, especially perinatal outcomes after FET were compared among the groups.ResultsThere were 137 patients in subgroup 1, 40 in subgroup 2, and 29 in subgroup 3. There were no differences in the baseline characteristics of the three groups. IVF-related data and FET-related data, such as endometrial thickness and ET no. Of embryoes, were similar among the three subgroups. The three subgroups showed no significant differences in implantation rate, biochemical pregnancy rate, abortion rate, clinical pregnancy rate or live birth rate. Besides, There was no significant difference in perinatal outcomes including very preterm delivery, preterm delivery, low birth weight, macrosomia, small for gestational age, large for gestational age, birth weight(g), birth-height(cm)and Apgar Scores.Conclusion(s)Compared with FET after their next menses, FET after two or more menstrual cycles after HSC-P does not necessarily produce superior outcomes.
Development and validation of a combined glycolysis and immune prognostic signature for lung squamous cell carcinoma
Authors: Huang Qiang , Yang Shan , Yan Hao , Chen Hong , Wang Yuzhu , Wang Yang 
Published: September 2022

Background: The involvement of glycolysis in the regulation of the tumor immune microenvironment has become a novel research field. In this study, the specific functions and clinical significance of glycolysis-related genes (GRGs) and immune-related genes (IRGs) were systematically characterized in lung squamous cell carcinoma (LUSC).Methods: We evaluated the prognostic value, interactions, somatic mutations, and copy-number variations of GRGs and IRGs in LUSC from a dataset of The Cancer Genome Atlas (TCGA). An integrated glycolysis–immune score (GIS) model was generated by random forest algorithm and stepwise Cox regression analysis. The predictive power of the GIS was examined by survival analysis, receiver operating characteristics, univariate and multivariate analyses, and subgroup analysis. The correlations between GIS and biological functions, glycolysis, immune activity, immune cell infiltration, and genomic changes were analyzed, and the potential of GIS to guide clinical treatment decisions was evaluated.Results: A total of 54 prognostic GRGs and IRGs were identified, and a strong correlation was noted among them. However, most of them had somatic mutations and a high incidence of CNV. The GIS model that contained two GRGs (PYGB and MDH1) and three IRGs (TSLP, SERPIND1, and GDF2) was generated and a high GIS indicated poor survival. Moreover, we found that low GIS was associated with immune pathway activation, M1 macrophage infiltration, and higher immune scores. Finally, patients with low GIS were more sensitive to chemotherapy and immunotherapy.Conclusion: An integrated model based on glycolysis and immune genes can distinguish the biological functions and immune infiltration patterns of individual tumors, quantitatively estimate the prognosis of patients with LUSC, and guide chemotherapy and immunotherapy decisions.
Identification of a novel homozygous LAMB3 mutation in a Chinese male with junctional epidermolysis bullosa and severe urethra stenosis: A case report
Authors: Wang Wei , Guo Qiang , Chen Jinshan , Zhang Xi , Li Chengyong , Li Shuangping , Liang Jialin , Hao Chuan , Wang Jingqi 
Published: September 2022

Introduction: Epidermolysis bullosa (EB) is a skin fragility disorder that is caused by molecular aberrations in the epidermal basement membrane zone. Based primarily on the cleavage plane within the skin, EB is classified into four major subtypes: EB simplex; junctional EB (JEB); dystrophic EB; and Kindler EB. The junctional form (JEB) can lead to blistering and a variety of extracutaneous complications, including genitourinary tract involvement. Despite therapeutic progress, treatment modalities for urological complications of JEB are currently limited.Results: We present the case of a Chinese male with intermediate JEB and profound urinary tract stenosis. Due to the progression of the urinary tract stenosis, he presented with repeated urological symptoms, such as high frequency of urination, painful urination, and difficult voiding. After birth, multiple blisters on the fingers, feet, and limbs, as well as nail dystrophies and spare hair were noted. Mutation analysis revealed that the patient carried a homozygous frameshift mutation in the LAMB3 gene [c.1172_1179delinsTGTGTGTGCAAGGAG/p. (P391Lfs*23)]. After receiving treatment for urethral dilatation, lingual mucosa for anterior urethroplasty, and repair of urethral stricture using a ventral onlay penile skin flap, the patient still experienced a relapse of urinary tract stenosis. Finally, the patient underwent perineal urethrostomy. In contrast, his older brother with similar urological symptoms received regular urethral dilatation, and the curative effect was positive.Conclusion: Here we report on a case with a novel LAMB3 mutation that led to JEB with profound urinary tract stenosis, which has expanded our experience in the treatment of EB urological complications.
Efficacy, effectiveness, and safety of herpes zoster vaccine in the immunocompetent and immunocompromised subjects: A systematic review and network meta-analysis
Authors: Xia Yue , Zhang Xue , Zhang Liuren , Fu Chuanxi 
Published: September 2022

ObjectiveTo investigate the efficacy, effectiveness and safety of recombinant zoster vaccine (RZV) and zoster vaccine live (ZVL) in immunocompetent and immunocompromised subjects.MethodsData sources: PubMed, EMBASE, Cochrane Library, and Web of Science databases (up to Jan 2022) were searched to identify English articles. Search terms included randomized controlled trials (RCTs), observational studies, herpes zoster, RZV, ZVL. Study Selection: Only randomized controlled trials (RCTs) evaluating vaccine efficacy and safety and observational studies assessing vaccine effectiveness (after a vaccine was approved for marketing) were included. Data Extraction: Two researchers independently screened the literature, extracted the data, and checked the each other results.ResultsSeventeen RCTs and 19 cohort studies were included. Among immunocompetent subjects, RZV was superior to ZVL at wide intervals (relative vaccine efficacy: 84%, 95% CI: 53%–95%; relative vaccine effectiveness: 49%, 95% CI: 21%–67%), across genders and subjects aged ≥ 60 years. Among immunocompromised subjects, RZV was superior to placebo in terms of vaccine efficacy (60%, 95% CI: 49%–69%). There was no difference between ZVL and placebo in those with selected immunosuppressive conditions. RZV was 45% (95% CI: 30%–59%) superior to ZVL in real-world practice. Compared with placebo, adverse events related to RZV were primarily related to injection-site and systemic, and RZV did not increase the risk of serious adverse events (SAEs) or death. There was no difference in the incidence of adverse events between groups with and without immunosuppression.ConclusionsBoth RZV and ZVL can reduce the risk of herpes zoster in both immunocompetent and immunocompromised subjects. RZV was well-tolerated in the study population and demonstrated stronger protection than ZVL.Systematic review registrationProspero CRD42022310495.