bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis
Authors: Kernan Kate F. , Ghaloul-Gonzalez Lina , Vockley Jerry , Lamb Janette , Hollingshead Deborah , Chandran Uma , Sethi Rahil , Park Hyun-Jung , Berg Robert A. , Wessel David , Pollack Murray M. , Meert Kathleen L. , Hall Mark W. , Newth Christopher J. L. , Lin John C. , Doctor Allan , Shanley Tom , Cornell Tim , Harrison Rick E. , Zuppa Athena F. , Banks Russel , Reeder Ron W. , Holubkov Richard , Notterman Daniel A. , Dean J. Michael , Carcillo Joseph A. 
Published: January 2022

Abstract
Purpose
Our understanding of inborn errors of immunity is increasing; however, their contribution to pediatric sepsis is unknown.

Methods
We used whole-exome sequencing (WES) to characterize variants in genes related to monogenic immunologic disorders in 330 children admitted to intensive care for severe sepsis. We defined candidate variants as rare variants classified as pathogenic or potentially pathogenic in QIAGEN’s Human Gene Mutation Database or novel null variants in a disease-consistent inheritance pattern. We investigated variant correlation with infection and inflammatory phenotype.

Results
More than one in two children overall and three of four African American children had immunodeficiency-associated variants. Children with variants had increased odds of isolating a blood or urinary pathogen (blood: OR 2.82, 95% CI: 1.12–7.10, p = 0.023, urine: OR: 8.23, 95% CI: 1.06–64.11, p = 0.016) and demonstrating increased inflammation with hyperferritinemia (ferritin $$\ge 500$$

≥
500

ng/mL, OR: 2.16, 95% CI: 1.28–3.66, p = 0.004), lymphopenia (lymphocyte count < 1000/µL, OR: 1.66, 95% CI: 1.06 – 2.60, p = 0.027), thrombocytopenia (platelet count < 150,000/µL, OR: 1.76, 95% CI: 1.12–2.76, p = 0.013), and CRP greater than 10 mg/dl (OR: 1.71, 95% CI: 1.10–2.68, p = 0.017). They also had increased odds of requiring extracorporeal membrane oxygenation (ECMO, OR: 4.19, 95% CI: 1.21–14.5, p = 0.019).

Conclusion
Herein, we describe the genetic findings in this severe pediatric sepsis cohort and their microbiologic and immunologic significance, providing evidence for the phenotypic effect of these variants and rationale for screening children with life-threatening infections for potential inborn errors of immunity.
Minimizing sevoflurane wastage by sensible use of automated gas control technology in the flow-i workstation: an economic and ecological assessment
Authors: Kalmar Alain F. , Van Der Vekens Nicky , De Rydt Fréderic , Allaert Silvie , Van De Velde Marc , Mulier Jan 
Published: January 2022

AbstractBoth ecological and economic considerations dictate minimising wastage of volatile anaesthetics. To reconcile apparent opposing stakes between ecological/economical concerns and stability of anaesthetic delivery, new workstations feature automated software that continually optimizes the FGF to reliably obtain the requested gas mixture with minimal volatile anaesthetic waste. The aim of this study is to analyse the kinetics and consumption pattern of different approaches of sevoflurane delivery with the same 2% end-tidal goal in all patients. The consumption patterns of sevoflurane of a Flow-i were retrospectively studied in cases with a target end-tidal sevoflurane concentration (Etsevo) of 2%. For each setting, 25 cases were included in the analysis. In Automatic Gas Control (AGC) regulation with software version V4.04, a speed setting 6 was observed; in AGC software version V4.07, speed settings 2, 4, 6 and 8 were observed, as well as a group where a minimal FGF was manually pursued and a group with a fixed 2 L/min FGF. In 45 min, an average of 14.5 mL was consumed in the 2L-FGF group, 5.0 mL in the minimal-manual group, 7.1 mL in the AGC4.04 group and 6.3 mL in the AGC4.07 group. Faster speed AGC-settings resulted in higher consumption, from 6.0 mL in speed 2 to 7.3 mL in speed 8. The Etsevo target was acquired fastest in the 2L-FGF group and the Etsevo was more stable in the AGC groups and the 2L-FGF groups. In all AGC groups, the consumption in the first 8 min was significantly higher than in the minimal flow group, but then decreased to a comparable rate. The more recent AGC4.07 algorithm was more efficient than the older AGC4.04 algorithm. This study indicates that the AGC technology permits very significant economic and ecological benefits, combined with excellent stability and convenience, over conventional FGF settings and should be favoured. While manually regulated minimal flow is still slightly more economical compared to the automated algorithm, this comes with a cost of lower precision of the Etsevo. Further optimization of the AGC algorithms, particularly in the early wash-in period seems feasible. In AGC mode, lower speed settings result in significantly lower consumption of sevoflurane. Routine clinical practice using what historically is called “low flow anaesthesia” (e.g. 2 L/min FGF) should be abandoned, and all anaesthesia machines should be upgraded as soon as possible with automatic delivery technology to minimize atmospheric pollution with volatile anaesthetics.
Longitudinal Assessment of a Manualized Group Treatment Program for Gambling Disorder: The Ohio Problem Gambling Treatment Model for Adults with Co-Occurring Disorders
Authors: Kruse-Diehr Aaron J. , Shamblen Stephen R. , Courser Matthew W. 
Published: January 2022

AbstractIndividuals with gambling disorder (GD) experience a host of negative psychosocial and physical health outcomes, yet few seek treatment. Of particular concern are individuals with co-occurring mental and behavioral health disorders, a group at higher risk for GD in the state of Ohio. To better serve this population, the Ohio Department of Mental Health and Addiction Services developed a group-based GD treatment manual for adults with co-occurring disorders. Over the course of 5 years, 353 individuals engaged in at least some of the manual’s 12 weekly modules, and more than one-third (n = 122) completed the entire curriculum. Participants who completed all 12 modules completed pre-and post-tests, and after controlling for covariates, participants significantly decreased their GD symptom severity, though changes in self-esteem and gambling urges were non-significant. These findings suggest the treatment manual holds promise at reducing gambling behaviors for individuals with co-occurring disorders, but further research is warranted to explore best practices on how to intervene on the psychological antecedents to gambling in this population.
In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells
Authors: Kurosaki Yoshifumi , Imoto Akemi , Kawakami Fumitaka , Ouchi Motoshi , Morita Asuka , Yokoba Masanori , Takenaka Tsuneo , Ichikawa Takafumi , Katagiri Masato , Nielsen Rikke , Ishii Naohito 
Published: January 2022

AbstractBardoxolone methyl [methyl-2-cyano-3, 12-dioxooleana-1, 9(11)dien-28-oate (CDDO-Me)], an activator of the nuclear factor erythroid-derived 2-related factor2 pathway, is a potential therapeutic candidate for the treatment of kidney diseases. However, its effect against cellular senescence remains unclear. This study aimed to investigate whether CDDO-Me protects cells against cisplatin-induced cellular senescence using an in vitro model. The human renal proximal tubular epithelial cell line HK-2 was treated with cisplatin for 6 h, followed by treatment with or without CDDO-Me (0.1 or 0.2 μmol/L). Senescence markers were analyzed using western blotting and real-time PCR. Apoptosis was evaluated through TUNEL staining. Cisplatin induced changes in the levels of markers specific for proliferation, cell cycle, and senescence in a time- and dose-dependent manner. Furthermore, IL-6 and IL-8 levels in the culture medium increased markedly. These data suggested that cellular senescence-like alterations occurred in HK-2 cells exposed to cisplatin. CDDO-Me treatment reversed the cisplatin-mediated alterations in the levels of cellular senescence markers. The antioxidant enzymes, HO1, NQO1, GPX1, and CAT were upregulated by CDDO-Me treatment. Furthermore, CDDO-Me treatment induced apoptosis in cisplatin-exposed HK-2 cells. Pretreatment with Ac-DEVD-CHO, the caspase inhibitor, suppressed the reversal effect of CDDO-Me against cisplatin-induced cellular senescence-like alterations. This study showed that CDDO-Me attenuated cisplatin-induced premature senescence of HK-2 cells. This beneficial effect may be related to Nrf2 activation. Our findings also showed that CDDO-Me induced apoptosis in cisplatin-treated HK-2 cells, potentially protecting the kidneys from cellular senescence. CDDO-Me appears to be a candidate treatment for acute kidney injury.
Enhancement of light field disparity maps by reducing the silhouette effect and plane noise
Authors: Lourenco Rui M. , Tavora Luis M. N. , Assuncao Pedro A. A. , Thomaz Lucas A. , Fonseca-Pinto Rui , Faria Sergio M. M. 
Published: January 2022

AbstractDuring the last decade, there has been an increasing number of applications dealing with multidimensional visual information, either for 3D object representation or feature extraction purposes. In this context, recent advances in light field technology, have been driving research efforts in disparity estimation methods. Among the existing ones, those based on the structure tensor have emerged as very promising to estimate disparity maps from Epipolar Plane Images. However, this approach is known to have two intrinsic limitations: (i) silhouette enlargement and (ii) irregularity of surface normal maps as computed from the estimated disparity. To address these problems, this work proposes a new method for improving disparity maps obtained from the structure-tensor approach by enhancing the silhouette and reducing the noise of planar surfaces in light fields. An edge-based approach is initially used for silhouette improvement through refinement of the estimated disparity values around object edges. Then, a plane detection algorithm, based on a seed growth strategy, is used to estimate planar regions, which in turn are used to guide correction of erroneous disparity values detected in object boundaries. The proposed algorithm shows an average improvement of 98.3% in terms of median angle error for plane surfaces, when compared to regular structure-tensor-based methods, outperforming state-of-the-art methods. The proposed framework also presents very competitive results, in terms of mean square error between disparity maps and their ground truth, when compared with their counterparts.
Multi-risk assessment in a historical city
Authors: Arrighi C. , Tanganelli M. , Cristofaro M. T. , Cardinali V. , Marra A. , Castelli F. , De Stefano M. 
Published: January 2022

AbstractNatural hazards pose a significant threat to historical cities which have an authentic and universal value for mankind. This study aims at codifying a multi-risk workflow for seismic and flood hazards, for site-scale applications in historical cities, which provides the Average Annual Loss for buildings within a coherent multi-exposure and multi-vulnerability framework. The proposed methodology includes a multi-risk correlation and joint probability analysis to identify the role of urban development in re-shaping risk components in historical contexts. The workflow is unified by exposure modelling which adopts the same assumptions and parameters. Seismic vulnerability is modelled through an empirical approach by assigning to each building a vulnerability value depending on the European Macroseismic Scale (EMS-98) and modifiers available in literature. Flood vulnerability is modelled by means of stage-damage curves developed for the study area and validated against ex-post damage claims. The method is applied to the city centre of Florence (Italy) listed as UNESCO World Heritage site since 1982. Direct multi-hazard, multi-vulnerability losses are modelled for four probabilistic scenarios. A multi-risk of 3.15 M€/year is estimated for the current situation. In case of adoption of local mitigation measures like floodproofing of basements and installation of steel tie rods, multi-risk reduces to 1.55 M€/yr. The analysis of multi-risk correlation and joint probability distribution shows that the historical evolution of the city centre, from the roman castrum followed by rebuilding in the Middle Ages, the late XIX century and the post WWII, has significantly affected multi-risk in the area. Three identified portions of the study area with a different multi-risk spatial probability distribution highlight that the urban development of the historical city influenced the flood hazard and the seismic vulnerability. The presented multi-risk workflow could be applied to other historical cities and further extended to other natural hazards.
Spatiotemporal variation in global floods with different affected areas and the contribution of influencing factors to flood-induced mortality (1985–2019)
Authors: Liu Tian , Shi Peijun , Fang Jian 
Published: January 2022

AbstractFloods are great threats to human life and property. Extensive research has investigated the spatiotemporal variation in flood occurrence, while few have studied the heterogeneity in global flood events of different sizes, which may require different coping strategies and risk reduction policies. In this study, we analysed the spatiotemporal patterns of global flood events with different affected areas (classified in three levels) during 1985–2019 and examined the contribution of different influencing factors to flood-induced mortality using Geodetector. The results show that (1) the increase in global flood frequency was mainly caused by Level II and Level III floods, and the average area affected by flood events has been increasing yearly since 1985. (2) In America and Africa, the frequency of Level III floods has increased monotonically. At the same time, the frequency of Level I floods in Europe and Level II floods in Asia has increased significantly. (3) For Europe and Asia, most of the deaths occurred with Level II floods; while for America and Africa, Level III floods caused the most mortality. (4) The top three factors contributing to the spatial heterogeneity in flood-induced mortality were the affected population, GDP per capita and flood duration. The contribution of each factor varied among the different types of floods. Topographic factors (percentage of mountainous area) magnified flood-induced mortality during extreme events with heavy rainfall, especially for Level III floods. The heterogeneity in flood frequency and flood-induced mortality indicates that flood protection measures should be more targeted. In addition, the increase in large-scale floods (Level III) highlights the need for transregional cooperation in flood risk management.
Customer Satisfaction with Branch Office Services in Higashihiroshima, Hiroshima Prefecture
Authors: Moteki Yasutoshi 
Published: January 2022

AbstractThis study empirically investigates the major factors that determine customer satisfaction in local government offices in Japan by using three categories of questions. They referred to customer satisfaction studies worldwide, especially to the expectancy disconfirmation model, the SERVQUAL model, and subsequent methods that emphasize customer’s direct experience. The on-site surveys were conducted at the Kurose branch office in Higashihiroshima City. A total of 240 responses were obtained over six weekdays. The regression analysis showed that staff responses and explanations were the most influential, followed by aspects related to the physical office and service delivery quality (adjusted R2 value of .51).
Determining nitrogen deficiencies for maize using various remote sensing indices
Authors: Burns Brayden W. , Green V. Steven , Hashem Ahmed A. , Massey Joseph H. , Shew Aaron M. , Adviento-Borbe M. Arlene A. , Milad Mohamed 
Published: January 2022

AbstractDetermining a precise nitrogen fertilizer requirement for maize in a particular field and year has proven to be a challenge due to the complexity of the nitrogen inputs, transformations and outputs in the nitrogen cycle. Remote sensing of maize nitrogen deficiency may be one way to move nitrogen fertilizer applications closer to the specific nitrogen requirement. Six vegetation indices [normalized difference vegetation index (NDVI), green normalized difference vegetation index (GNDVI), red-edge normalized difference vegetation index (RENDVI), triangle greenness index (TGI), normalized area vegetation index (NAVI) and chlorophyll index-green (CIgreen)] were evaluated for their ability to detect nitrogen deficiency and predict grain maize grain yield. Strip trials were established at two locations in Arkansas, USA, with nitrogen rate as the primary treatment. Remote sensing data was collected weekly with an unmanned aerial system (UAS) equipped with a multispectral and thermal sensor. Relationships among index value, nitrogen fertilizer rate and maize growth stage were evaluated. Green NDVI, RENDVI and CIgreen had the strongest relationship with nitrogen fertilizer treatment. Chlorophyll Index-green and GNDVI were the best predictors of maize grain yield early in the growing season when the application of additional nitrogen was still agronomically feasible. However, the logistics of late season nitrogen application must be considered.
Extraction of transforming sequences and sentence histories from writing process data: a first step towards linguistic modeling of writing
Authors: Mahlow Cerstin , Ulasik Malgorzata Anna , Tuggener Don 
Published: January 2022

AbstractProducing written texts is a non-linear process: in contrast to speech, writers are free to change already written text at any place at any point in time. Linguistic considerations are likely to play an important role, but so far, no linguistic models of the writing process exist. We present an approach for the analysis of writing processes with a focus on linguistic structures based on the novel concepts of transforming sequences, text history, and sentence history. The processing of raw keystroke logging data and the application of natural language processing tools allows for the extraction and filtering of product and process data to be stored in a hierarchical data structure. This structure is used to re-create and visualize the genesis and history for a text and its individual sentences. Focusing on sentences as primary building blocks of written language and full texts, we aim to complement established writing process analyses and, ultimately, to interpret writing timecourse data with respect to linguistic structures. To enable researchers to explore this view, we provide a fully functional implementation of our approach as an open-source software tool and visualizations of the results. We report on a small scale exploratory study in German where we used our tool. The results indicate both the feasibility of the approach and that writers actually revise on a linguistic level. The latter confirms the need for modeling written text production from the perspective of linguistic structures beyond the word level.
Can differences in publisher size account for the relatively low prices of the journals available to master’s universities through commercial publishers’ databases? The importance of price discrimination and substitution effects
Authors: Walters William H. 
Published: January 2022

AbstractUsing price quotes and invoices for thousands of full-text databases and single-journal subscriptions, this study confirms that for a typical master’s university, the journals acquired through commercial publishers’ databases cost substantially less than those acquired through the databases of scholarly societies, universities, and other nonprofits. Moreover, the lower prices of commercial publishers’ journals cannot be readily attributed to publisher size (number of journals published) or to any of several other explanatory variables. There is a weak, direct association between publisher size and price among the for-profit journals but a stronger, inverse relationship between publisher size and price among the nonprofit journals. These findings, along with the results of previous research, suggest that resource providers may have incentives to keep prices low due to the collection development strategies adopted by many teaching-oriented colleges and universities. If the library’s goal is to hold a sufficient number of high-quality journals rather than to provide immediate access to every wanted journal, particular journals and databases may be regarded as substitutes even when each product provides unique content. Many U.S. bachelor’s and master’s institutions have goals different from those of the major research universities, and commercial publishers (along with some of the larger nonprofits) seem to recognize this when setting and negotiating prices.
Human pose, hand and mesh estimation using deep learning: a survey
Authors: Toshpulatov Mukhiddin , Lee Wookey , Lee Suan , Haghighian Roudsari Arousha 
Published: January 2022

AbstractHuman pose estimation is one of the issues that have gained many benefits from using state-of-the-art deep learning-based models. Human pose, hand and mesh estimation is a significant problem that has attracted the attention of the computer vision community for the past few decades. A wide variety of solutions have been proposed to tackle the problem. Deep Learning-based approaches have been extensively studied in recent years and used to address several computer vision problems. However, it is sometimes hard to compare these methods due to their intrinsic difference. This paper extensively summarizes the current deep learning-based 2D and 3D human pose, hand and mesh estimation methods with a single or multi-person, single or double-stage methodology-based taxonomy. The authors aim to make every step in the deep learning-based human pose, hand and mesh estimation techniques interpretable by providing readers with a readily understandable explanation. The presented taxonomy has clearly illustrated current research on deep learning-based 2D and 3D human pose, hand and mesh estimation. Moreover, it also provided dataset and evaluation metrics for both 2D and 3DHPE approaches.