bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions and mediation between multilingual clients and their psychotherapist
Authors: Dewaele Jean-Marc , Costa Beverley , Rolland Louise , Cook Sally 
Published: April 2022

The editors pointed out that all interactions require some degree of mediation. In other words, a common ground needs to be established on which communication can be based, and when difficulties emerge mediation will be required. In this paper, we will argue that there are contexts where the assumption of common ground is stronger or weaker depending on the training, experience and disciplinary background of those involved in the interaction. The need for mediation may thus be greater in contexts where the assumption of common ground is over-optimistic, and where the consequences of not spotting the potential misunderstanding, and hence skipping mediation, may be serious. Language professionals are very much aware of variation in language proficiency and are less likely to assume complete common ground with fluent Foreign Language (LX) users than professionals from other backgrounds for whom language is merely a technical tool that does not merit special attention. Thus, considering an interlocutor who can talk easily about the weather in an LX, a Foreign Language teacher is less likely to assume complete linguistic common ground than a psychotherapist whose main concern is to locate the source of a client’s issues. The language teacher has been taught that students may have linguistic and cultural gaps that are not immediately apparent and that meaning may need to be negotiated in the classroom. The psychotherapist has been trained to try to understand the client’s worldview, but frequently that training ignores their clients’ linguistic profiles and experiences. Negotiation about meanings and across differences and power differentials, which goes to the heart of psychotherapeutic communication, often ignores the linguistic gap. In particular, psychotherapists (especially monolingual ones) may be less aware that multilinguals can have different levels of proficiency in different discourse domains (Grosjean, 2016). In other words, the ability to converse fluently in the LX about certain everyday topics does not necessarily imply an ability to convey subtle, complex emotions in that language. Clients themselves may be unaware of this.
The aim of the present paper is therefore to highlight the need for extra awareness among psychotherapists about both visible and invisible linguistic and cultural obstacles to emotion communication that will require mediation with their LX clients, using appropriate strategies.
Aandacht voor wat werkt
Authors: Bomhoff Manja , Brander Geert , van Pelt Dennis , Renema Ytzen , Rutz Suzanne , van der Vlugt Yvonne 
Published: April 2022

Aandacht voor wat werkt – Vijf korte verhalen van inspecteurs over de effecten van hun werk
Als het gaat om de effecten van het toezicht, hebben inspecteurs zelf ook vragen. Wat werkt, waarom en voor wie en in welke situatie? Voor het verbeteren van de kwaliteit van het toezicht is het belangrijk dat inspecteurs zulke vragen lerend kunnen onderzoeken. Zij kunnen signaleren wat in een bepaalde context wel of niet lijkt te werken en zij kunnen passende verbetervoorstellen ontwikkelen en toepassen. In het ‘Aandacht voor wat werkt’-project vormde de nieuwsgierigheid van inspecteurs het startpunt. De vijf samengestelde verhalen laten zien hoe inspecteurs onderzoekend kunnen leren en wat daar voor nodig is op het niveau van de inspecteur en de inspectieorganisatie.
De meerwaarde van kwalitatief onderzoek om effecten van interventies te bepalen
Authors: Jansen Laurie , Tanihatu Whitney 
Published: April 2022

De meerwaarde van kwalitatief onderzoek om effecten van interventies te bepalen
Het uitvoeren van effectmetingen door toezichthouders draagt bij aan evidence based toezicht. In de praktijk lopen toezichthouders tegen o.a. ethische, methodologische en praktische uitdagingen aan en is het vaak niet mogelijk om causaliteit aan te tonen. Met een praktijkvoorbeeld toont de NVWA aan dat het streven naar beredeneerde plausibiliteit een werkbaar en pragmatisch alternatief is. De NVWA kiest voor mixed methods in haar onderzoek naar de effectiviteit van een interventiemix op de naleving. Een belangrijke les is dat het combineren van kwantitatieve en kwalitatieve onderzoeksmethoden leidt tot complementaire inzichten en goed kan aansluiten op de onvoorspelbare praktijk van een toezichthouder.
In gesprek met David de Kam
Authors: Merz Anna , Welp Pieter 
Published: April 2022

In gesprek met David de Kam
In de serie ‘in gesprek met een pas gepromoveerde onderzoeker’ geven we aandacht aan promotieonderzoeken die voor toezichthouders relevant zijn. Hiervoor interviewen we als redactie van het Tijdschrift voor Toezicht (recent) gepromoveerde onderzoekers over hun onderzoek en de betekenis ervan voor het toezicht.In dit interview spraken Anna Merz en Pieter Welp, redacteuren van het Tijdschrift voor Toezicht, met David de Kam, die in 2020 promoveerde aan de Erasmus Universiteit Rotterdam op zijn onderzoek naar de wijze waarop de Inspectie Gezondheidszorg en Jeugd de kwaliteit en veiligheid van zorg inspecteerbaar maakt en welke effecten dit heeft. David werkt momenteel als onderzoekscoördinator bij het ministerie van Sociale Zaken en Werkgelegenheid.
Testa QuantiFERON TB in TB Plus v Sloveniji v obdobju 2008–2019
Authors: Skamen Urška , Sodja Eva , Žolnir-Dovč Manca 
Published: April 2022

Izhodišča: Test QuantiFERON TB (QFT TB) je prvenstveno namenjen za odkrivanje latentne (LTBI) okužbe z bacili tuberkuloze (TB). Članek obsega retrospektivno analizo rezultatov testa QFT TB v Sloveniji med letoma 2008 in 2019, opozarja na vplive predanalitskih dejavnikov na rezultate testa ter govori o razlogih za nastanek nejasnih rezultatov in o občutljivosti testa pri bolnikih z aktivno obliko TB.
Metode: V obdobju 2008–2019 smo v Laboratoriju za mikobakterije Klinike Golnik s testom QFT TB testirali 29.352 vzorcev krvi bolnikov iz različnih zdravstvenih ustanov v Sloveniji. Na rezultatih testa QFT TB smo izvedli retrospektivno analizo.
Rezultati: Delež pozitivnih rezultatov testa QFT TB se z leti postopno znižuje. V letu 2008 je znašal 20,8 %, v letu 2019 pa 10,7 %, kar pomeni, da je v zadnjih dvanajstih letih upadel za 48,6 %. Največjo težavo predstavljajo nejasni rezultati (letno povprečno 4,3 %), saj so za zdravnika nepovedni. Občutljivost testa QFT TB pri bolnikih z aktivno obliko TB je 82,9 %, kar je primerljivo s podatki iz tujine.
Zaključek: Pomembno je, da pri odvzemu in pošiljanju krvi dosledno sledimo navodilom, saj je test QFT TB zelo občutljiv na predanalitske dejavnike in klinično stanje preiskovancev. Delež pozitivnih rezultatov testa QFT TB z leti pospešeno upada, kar je povezano z napori za omejitev širjenja TB in upadom primerov aktivne TB v naši državi.
An update on halal slaughter: Current methods and ongoing research on halal meat production techniques and their implications for animal welfare
Authors: Fuseini A , Teye M , Lever J 
Published: April 2022

AbstractThe ethical and economic significance of slaughtering animals for consumption by people of faith cannot be underestimated. On one hand, there are concerns for the welfare of animals during rearing, transport and slaughter, on the other, the market for halal meat products continues to grow at an exponential rate which has attracted the attention of independent and mainstream retailers. This paper considers the slaughter methods approved for the main animal species slaughtered for consumption by Muslims: beef, lamb, goats and poultry. It further examines the rationale for approving and rejecting certain methods of stunning and the implications this has for the welfare of animals. Areas where further research is needed to improve animal welfare during halal slaughter are also highlighted, and the authors have argued why a dialogue between animal welfare researchers, Islamic scholars and halal certification or accreditation bodies is vital in creating knowledge exchange between key stakeholders with a view to improving animal welfare during halal meat production.
Role of Gabanergic and, or Serotonergic in the Anti-seizure Activity of Methanol Extract of Crinum jagus (J. Thomps) in Experimental Mice
Authors: Wakeel O. K. , Adebayo-Moggaji R. A. , Wakeel D. O. , Abiodun O. O. , Kolawole O. T. , Onaolapo A. Y. , Onaolapo O. J. , Subbair H. G. 
Published: April 2022

Objective: Crinum jagus is used in traditional African medicine in the treatment of epilepsy, pain and inflammations.
Methods: Anticonvulsant activity was investigated using picrotoxin (PCT) and strychnine (STR) tests in experimental paradigm.
Results: Crinum jagus leaf methanol extract (200, 400, and 800 mg kg−1) potentiated hexobarbitone-induced sleeping time and significantly (p<0.05) shortened the duration of convulsions in PCT-induced seizures. Delay in the onset of convulsions in PCT-induced seizure were very significant (p<0.05). Reduction in the frequency of seizures was also significant (p<0.05) in the test. Diazepam (5 mg kg−1) was used as reference anticonvulsant drugs in the experimental models. While, CJB failed to protect the animals against picrotocin-induced convulsion. Neither the extract of CJL nor CJB confer significant effect on STR-induced convulsion. Flumazenil (GABA receptor antagonist) and cyproheptadine (5-HT2 receptor antagonist) blocked the effect of CJL extract in the PCT tests significantly suggesting that Crinum jagus may be acting by enhancing the effects of the GABAergic and serotonergic systems.
Conclusion: The data obtained suggest that methanol leaf extract of C. jagus possessed significant anticonvulsant effect, thereby confirming the traditional uses of C. jagus in the treatment of epilepsies; mechanisms of which may involve interaction with GABAergic and serotonergic pathway.
Interrelationships between Leptin and Thyroid Profile in Overweight/Obese Urban Population of Manipur
Authors: Singh Loushambam Samananda , Govindaraj Y. , Devi Ksh. Gomti , Kanan W. 
Published: April 2022

Aims: The goal of this study was to determine the relationship between leptin and thyroid profile in overweight/obese Manipur individuals.
Materials and Methods: A total of 250 people (of either gender) between the ages of 20 and 65 were included in the study. The body mass index (BMI) was computed using the height and weight of the individual. Blood samples were used to assess serum leptin, thyroxine (T4), and thyroid stimulating hormone (TSH) levels. Significant variations between the groups were examined, as well as leptin and thyroid associations with various BMIs.
Findings: Leptin levels were significantly higher in the overweight/obese group (12.73 ± 9.93 ng/ml) than in the control group (6.85 ± 6.49 ng/ml), (P <0.01). T4 levels did not differ significantly between normal (7.83 ± 1.51 µg/dl) and overweight/obese individuals (8.49 ± 2.00 µg/dl) whereas, TSH levels differed significantly between normal (2.79 ± 2.72 µIU/ml) and overweight/obese subjects (2.32 ± 1.54 µIU/ml), (P <0.05). A positive significant correlation was found between BMI and leptin (r = 0.38; P = 0.00) as well as between BMI and T4 (r = 0.14; P = 0.02). BMI and TSH did not have any correlations. Furthermore, there were no significant relationships between leptin and T4 or TSH.
Conclusion: The leptin and thyroid hormone are strongly linked in those who are overweight/obese.
Novel de novo POLR3B mutations responsible for demyelinating Charcot–Marie–Tooth disease in Japan
Authors: Ando Masahiro , Higuchi Yujiro , Yuan Jun‐Hui , Yoshimura Akiko , Kitao Ruriko , Morimoto Takehiko , Taniguchi Takaki , Takeuchi Mika , Takei Jun , Hiramatsu Yu , Sakiyama Yusuke , Hashiguchi Akihiro , Okamoto Yuji , Mitsui Jun , Ishiura Hiroyuki , Tsuji Shoji , Takashima Hiroshi 
Published: April 2022

AbstractBackgroundBiallelic POLR3B mutations cause a rare hypomyelinating leukodystrophy. De novo POLR3B heterozygous mutations were recently associated with afferent ataxia, spasticity, variable intellectual disability, and epilepsy, and predominantly demyelinating sensorimotor peripheral neuropathy.MethodsWe performed whole‐exome sequencing (WES) of DNA samples from 804 Charcot–Marie–Tooth (CMT) cases that could not be genetically diagnosed by DNA‐targeted resequencing microarray using next‐generation sequencers. Using WES data, we analyzed the POLR3B mutations and confirmed their clinical features.ResultsWe identified de novo POLR3B heterozygous missense mutations in two patients. These patients presented with early‐onset demyelinating sensorimotor neuropathy without ataxia, spasticity, or cognitive impairment. Patient 1 showed mild cerebellar atrophy and spinal cord atrophy on magnetic resonance imaging and eventually died of respiratory failure in her 50s. We classified these mutations as pathogenic based on segregation studies, comparison with control database, and in silico analysis.ConclusionOur study is the third report on patients with demyelinating CMT harboring heterozygous POLR3B mutations and verifies the pathogenicity of POLR3B mutations in CMT. Although extremely rare in our large Japanese case series, POLR3B mutations should be added to the CMT‐related gene panel for comprehensive genetic screening, particularly for patients with early‐onset demyelinating CMT.
Synergetic Horizontal Dipole Orientation Induction for Highly Efficient and Spectral Stable Thermally Activated Delayed Fluorescence White Organic Light‐Emitting Diodes
Authors: Peng Xiaomei , Qiu Weidong , Li Wenqi , Li Mengke , Xie Wentao , Li Wei , Lin Jianying , Yang Jiaji , Li Xin , Su Shi‐Jian 
Published: April 2022

AbstractRadiative exciton generation and light out‐coupling are two crucial factors for highly efficient organic light‐emitting diodes (OLEDs). Herein, a thermally activated delayed fluorescence (TADF) material DspiroS‐TRZ with high horizontal dipole ratio (HDR, Θ// = 82%) is utilized as the blue emitter as well as the host for an orange‐red TADF emitter TPA‐AQ to fabricate white OLEDs. A synergetic horizontal dipole orientation induction on the transition dipole moment of TPA‐AQ is achieved by the highly orientated DspiroS‐TRZ, resulting in high HDR (Θ// = 96%) of the orange‐red emitter. Owing to the simultaneous efficient triplet exciton utilization and highly orientated binary system, a maximum external quantum efficiency (EQEmax) of 29.3% is achieved for single emission layer (EML) white OLED, with an excellent white light out‐coupling efficiency of 34%. In addition, the carrier recombination in the EML is further regulated by inserting an exciton regulation emission layer, which can relieve the trapping effect of the orange‐red emitter and guarantee stable Langevin recombination and energy transfer processes for improved electroluminescence spectral stability. An EQEmax of 31.2% is ultimately achieved for the double‐EML white OLED, highlighting the key role of horizontal dipole orientation induction and carrier recombination modulation for highly efficient and spectral stable white OLEDs.
The Technological Advancement to Engineer Next‐Generation Stent‐Grafts: Design, Material, and Fabrication Techniques
Authors: Vahabli Ebrahim , Mann James , Heidari Behzad Shiroud , Lawrence‐Brown Michael , Norman Paul , Jansen Shirley , De‐Juan‐Pardo Elena , Doyle Barry 
Published: April 2022

AbstractEndovascular treatment of aortic disorders has gained wide acceptance due to reduced physiological burden to the patient compared to open surgery, and ongoing stent‐graft evolution has made aortic repair an option for patients with more complex anatomies. To date, commercial stent‐grafts are typically developed from established production techniques with simple design structures and limited material ranges. Despite the numerous updated versions of stent‐grafts by manufacturers, the reoccurrence of device‐related complications raises questions about whether the current manfacturing methods are technically able to eliminate these problems. The technology trend to produce efficient medical devices, including stent‐grafts and all similar implants, should eventually change direction to advanced manufacturing techniques. It is expected that through recent advancements, especially the emergence of 4D‐printing and smart materials, unprecedented features can be defined for cardiovascular medical implants, like shape change and remote battery‐free self‐monitoring. 4D‐printing technology promises adaptive functionality, a highly desirable feature enabling printed cardiovascular implants to physically transform with time to perform a programmed task. This review provides a thorough assessment of the established technologies for existing stent‐grafts and provides technical commentaries on known failure modes. They then discuss the future of advanced technologies and the efforts needed to produce next‐generation endovascular implants.
Studying Complex Evolution of Hyperelastic Materials under External Field Stimuli using Artificial Neural Networks with Spatiotemporal Features in a Small‐Scale Dataset
Authors: Yu Songlin , Chai Haiyang , Xiong Yuqi , Kang Ming , Geng Chengzhen , Liu Yu , Chen Yanqiu , Zhang Yaling , Zhang Qian , Li Changlin , Wei Hao , Zhao Yuhang , Yu Fengmei , Lu Ai 
Published: April 2022

AbstractDeep‐learning (DL) methods, in consideration of their excellence in dealing with highly complex structure–performance relationships for materials, are expected to become a new design paradigm for breakthroughs in material performance. However, in most cases, it is impractical to collect massive‐scale experimental data or open‐source theoretical databases to support training DL models with sufficient prediction accuracy. In a dataset consisting of 483 porous silicone rubber observations generated via ink‐writing additive manufacturing, this work demonstrates that constructing low‐dimensional, accurate descriptors is the prerequisite for obtaining high‐precision DL models based on small experimental datasets. On this basis, a unique convolutional bidirectional long short‐term memory model with spatiotemporal features extraction capability is designed, whose hierarchical learning mechanism further reduces the requirement for the amount of data by taking full advantage of data information. The proposed approach can be expected as a powerful tool for innovative material design on small experimental datasets, which can also be used to explore the evolutionary mechanisms of the structures and properties of materials under complex working conditions.
Targeted Drug/Gene/Photodynamic Therapy via a Stimuli‐Responsive Dendritic‐Polymer‐Based Nanococktail for Treatment of EGFR‐TKI‐Resistant Non‐Small‐Cell Lung Cancer
Authors: Huang Jinxing , Zhuang Cheng , Chen Jie , Chen Xuanming , Li Xiaojie , Zhang Ting , Wang Bing , Feng Qiyi , Zheng Xiuli , Gong Meng , Gong Qiyong , Xiao Kai , Luo Kui , Li Weimin 
Published: April 2022

AbstractYes‐associated protein (YAP) has been identified as a key driver for epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance. Inhibition of YAP expression could be a potential therapeutic option for treating non‐small‐cell lung cancer (NSCLC). Herein, a nanococktail therapeutic strategy is proposed by employing amphiphilic and block‐dendritic‐polymer‐based nanoparticles (NPs) for targeted co‐delivery of EGFR‐TKI gefitinib (Gef) and YAP‐siRNA to achieve a targeted drug/gene/photodynamic therapy. The resulting NPs are effectively internalized into Gef‐resistant NSCLC cells, successfully escape from late endosomes/lysosomes, and responsively release Gef and YAP‐siRNA in an intracellular reductive environment. They preferentially accumulate at the tumor site after intravenous injection in both cell‐line‐derived xenograft (CDX) and patient‐derived xenograft (PDX) models of Gef‐resistant NSCLC, resulting in potent antitumor efficacy without distinct toxicity after laser irradiation. Mechanism studies reveal that the cocktail therapy could block the EGFR signaling pathway with Gef, inhibit activation of the EGFR bypass signaling pathway via YAP‐siRNA, and induce tumor cell apoptosis through photodynamic therapy (PDT). Furthermore, this combination nanomedicine can sensitize PDT and impair glycolysis by downregulating HIF‐1α. These results suggest that this stimuli‐responsive dendritic‐polymer‐based nanococktail therapy may provide a promising approach for the treatment of EGFR‐TKI resistant NSCLC.
Metal–Organic Nanosheets (MONs): Exfoliation by Mechanical Grinding and Iodine Capture
Authors: Tamuly Parag , Sama Farasha , Moorthy Jarugu Narasimha 
Published: April 2022

AbstractAn electron‐rich π‐conjugated organic linker H4BPDP (BPDP = biphenyl dipyrrole tetracarboxylic acid) is designed and subjected to metal‐assisted self‐assembly to afford a layered metal–organic framework (MOF), i.e., Cd‐BPDP. Single crystal X‐ray structure determination and analysis show that two corrugated layers of the MOF are intertwined to yield thick strands of porous 2D metal–organic nanosheets (MONs). It is shown that the latter can be delaminated by ultrasonication‐induced liquid‐phase exfoliation and mechanical grinding techniques, as evidenced by Tyndall light scattering and comprehensive microscopy investigations that include field emission scanning electron microscopy (FESEM), atomic force microscopy, and high‐resolution transmission electron microscopy. The MONs accessed by grinding permit notable capture of iodine when compared to the bulk layered MOF, i.e., Cd‐BPDP; the extent of iodine capture can be correlated with the magnitude exfoliation, which is essentially determined by the duration of grinding. The observed notable iodine capture is attributed to i) a large increase in surface area with exfoliation, ii) ability of the e‐rich π‐conjugated organic linker to form a charge‐transfer complex with iodine, and iii) the presence of free and uncoordinated carboxylic acids of the linker that reinforce binding of iodine through charge transfer. Thus, a notable capture of iodine by 2D MONs generated by mechanical exfoliation of a layered MOF constructed from an e‐rich π‐extended organic linker is compellingly demonstrated.
Plasma Focused Ion Beam Tomography for Accurate Characterization of Black Silicon Validated by Full Wave Optical Simulation
Authors: Zhang Yu , Veeken Tom , Wang Shaozhou , Scardera Giuseppe , Abbott Malcolm , Payne David , Polman Albert , Hoex Bram 
Published: April 2022

AbstractBlack silicon (BSi) is a branch of silicon material whose surface is specially processed to a micro/nanoscale structure, which can achieve ultra‐low reflectance or ultra‐high electrochemical reactivity. The diversity and complex surface structures of BSi make it challenging to commercialize BSi devices. Modeling and simulation are commonly used in the semiconductor industry to help in better understanding the material properties, predict the device performance, and provide guidelines for fabrication parameters’ optimization. The biggest challenge for BSi device modeling and simulation is obtaining accurate input surface morphological data. In this work, the 3D models of challenging BSi textures are compared as obtained by atomic force microscopy (AFM) and plasma focused ion beam (PFIB) tomography techniques. In previous work, the PFIB tomography workflow toward the application of surface topography is optimized. In this work, the 3D models obtained from both AFM and PFIB are comprehensively compared, by using the surface models as inputs for finite‐difference time‐domain‐based optical simulation. The results provide strong evidence that PFIB tomography is a better choice for characterizing highly roughened surface such as BSi and provides surface 3D models with better reliability and consistency.