bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kiss and spit metabolomics highlights the role of the host cN-II enzyme on purine metabolism during pathogen infection
Authors: Gallego-Lopez Gina M. , Olson William J. , Tibabuzo-Perdomo Andres M. , Stevenson David , Amador-Noguez Daniel , Knoll Laura J. 
Published: June 2022

AbstractIntracellular pathogens are auxotrophic for many metabolites and must rely on the host. While this reliance is well established, how pathogens manipulate host metabolism to their benefit is not understood. For intracellular pathogens, distinguishing the origin of the metabolite as host- or pathogen-derived is challenging. The obligate intracellular parasite Toxoplasma gondii alters the host cell by a pre-invasion process known as “kiss and spit”, where the contents of the parasite rhoptry organelles are secreted into the host cytoplasm before invasion occurs. This separation of microbe from the host offers a rare opportunity to demonstrate pathogen manipulation of the host. Using mass spectrometry-based metabolomics, we determined that kiss and spit changed host metabolites in nucleotide synthesis, the pentose phosphate pathway, glycolysis, and amino acid synthesis. An increase in 2,3-bisphosphoglycerate (2,3-BPG) abundance led us to hypothesize that high levels of host 2,3-BPG contribute to the activation of host cytosolic nucleosidase II (cN-II) to alter purine availability. Treatment with the cN-II inhibitor fludarabine and a cell line with a cN-II genetic knockout reduced T. gondii growth. Our results demonstrate that T. gondii rhoptry contents discharged during kiss and spit remodel host metabolism. They also suggest that T. gondii manipulates the host cN-II enzyme to acquire its necessary purine metabolites.
Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
Authors: Mason Devon E. , Camacho Paula , Goeckel Megan E. , Tobin Brendan R. , Vega Sebastián L. , Wu Pei-Hsun , Johnson Dymonn , Heo Su-Jin , Wirtz Denis , Burdick Jason A. , Wood Levi , Chow Brian Y. , Stratman Amber N. , Boerckel Joel D. 
Published: June 2022

AbstractVascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. Here, we interrogated the mechanotransductive feedback dynamics that govern endothelial cell motility and vascular morphogenesis. We show that the transcriptional regulators, YAP and TAZ, are activated by mechanical cues to transcriptionally limit cytoskeletal and focal adhesion maturation, forming a conserved mechanotransductive feedback loop that mediates human endothelial cell motilityin vitroand zebrafish intersegmental vessel (ISV) morphogenesisin vivo. This feedback loop closes in 4 hours, achieving cytoskeletal equilibrium in 8 hours. Feedback loop inhibition arrested endothelial cell migrationin vitroand ISV morphogenesisin vivo. Inhibitor washout at 3 hrs, prior to feedback loop closure, restored vessel growth, but washout at 8 hours, longer than the feedback timescale, did not, establishing lower and upper bounds for feedback kineticsin vivo. Mechanistically, YAP and TAZ induced transcriptional suppression of RhoA signaling to maintain dynamic cytoskeletal equilibria. Together, these data establish the mechanoresponsive dynamics of a transcriptional feedback loop necessary for persistent endothelial cell migration and vascular morphogenesis.
Cytoplasmic divisions without nuclei
Authors: Bakshi Anand , Iturra Fabio Echegaray , Alamban Andrew , Rosas-Salvans Miquel , Dumont Sophie , Aydogan Mustafa G. 
Published: June 2022

AbstractCytoplasmic divisions have been commonly considered a sequel to nuclear divisions, even in the absence of DNA replication. Here we found in fruit fly embryos that the cytoplasm can compartmentalize and divide without nuclei. Our targeted screen for potential necessary and sufficient conditions revealed that, although the cytoplasmic compartments are tightly associated with centrosomes, they can form without astral microtubules and divide without centrioles. Although a focal pool of microtubules is necessary for maintaining cytoplasmic compartments, this is not sufficient for their initial formation. Actin filaments are similarly an essential component of cytoplasmic compartments; however, their myosin II-based contractility is unexpectedly dispensable for divisions. We show that the myosin II-based contractility is instead involved in regulating the pace of these divisions. Importantly, our results revealed that the cytoplasmic divisions without nuclei can occur in a periodic manner autonomously of the Cdk-Cyclin oscillator that normally drives the cell cycle. We demonstrate that such autonomy of cytoplasmic divisions is preserved even in normal development, where it is leveraged to extrude mitotically delayed nuclei from the blastoderm, protecting the synchrony of rapid nuclear divisions against local delays in mitotic entry. We propose that an active coordination between otherwise autonomous cycles of cytoplasmic and nuclear divisions acts as a quality control mechanism for genome integrity and partitioning in development.
Life-course socioeconomic factors are associated with markers of epigenetic aging in a population-based study
Authors: Petrovic Dusan , Carmeli Cristian , Sandoval José Luis , Bodinier Barbara , Chadeau-Hyam Marc , Schrempft Stephanie , Ehret Georg , Dhayat Nasser Abdalla , Ponte Belén , Pruijm Menno , Dermitzakis Emmanouil , Vineis Paolo , Gonseth-Nusslé Sémira , Guessous Idris , McCrory Cathal , Bochud Murielle , Stringhini Silvia 
Published: June 2022

AbstractAdverse socioeconomic circumstances negatively affect the functioning of biological systems, but the underlying mechanisms remain only partially understood. Here, we explore the associations between life-course socioeconomic factors and four markers of epigenetic aging in a population-based setting.We used data from a population-based study conducted in Switzerland (SKIPOGH) to assess the association between childhood, adulthood, and life-course socioeconomic indicators, and blood-derived markers of epigenetic aging (Levine’s, DunedinPoAm38, GrimAge epigenetic age acceleration (EAA) and the mortality risk score (MS)). We used mixed regression to explore the associations between socioeconomic indicators and markers of epigenetic aging independently, and counterfactual mediation to investigate the mechanisms underlying the life-course socioeconomic gradient in epigenetic aging.Individuals reporting a low father’s occupation, adverse financial conditions in childhood, a low income, having financial difficulties, or experiencing unfavorable socioeconomic trajectories were epigenetically older than their more advantaged counterparts. Specifically, this corresponded to an average increase of 1.0-1.5 years for Levine’s epigenetic age when compared to chronological age, 1.1-1.5 additional years for GrimAge, 5%-8% higher DunedinPoAm38 EAA, and 2%-5% higher MS score. By exploring the life-course mechanisms underlying the socioeconomic gradient in epigenetic aging, we found that both childhood and adulthood socioeconomic factors contributed to epigenetic aging, and that detrimental lifestyle factors mediated the relation between socioeconomic circumstances in adulthood and EAA.Our study provides novel empirical evidence for a “sensitive-period” life-course model, whereby adverse socioeconomic circumstances in childhood and adulthood negatively affected epigenetic aging. Counterfactual mediation analyses further showed that the effect of socioeconomic factors in adulthood operated through detrimental lifestyle factors, whereas associations involving early-life socioeconomic factors were less clear.
The current state of benchmarking use and networks in facilities management
Authors: Dodd Justin R. , Smithwick Jake , Call Steven , Kasana Dipin 
Published: June 2022

PurposeThe purpose of this paper is to address the knowledge gap on the use of benchmarking techniques as utilized by facilities management (FM) professionals for the purpose of identifying means to improve industry benchmarking practices and guide the direction of future FM benchmarking research.Design/methodology/approachData were collected through surveying 585 FM practitioners representing various countries, organization sizes, types, industries. The data were summarized and analyzed through creating frequency tables, charts, and cross-tabulations. The survey results were compared to a previously published study on benchmarking use to identify the similarities and differences between benchmarking for FM functions vs core business functions.FindingsThe findings indicate that while FM-oriented benchmarking has been adopted at similar levels as other industries, FM-oriented benchmarking tends to be simplistic, lacks a strategic position in the company, often relies upon self-report survey data, is often performed by an individual with no formal benchmarking team and does not utilize process benchmarking or benchmarking networks. These findings emphasize the need for benchmarking education, advocacy for FM as a strategic business partner, the development of verified data sources and networks specifically for the unique greater facilities management field functions.Practical implicationsThese findings provide needed data on the state of FM practitioner use of benchmarking specifically for FM functions in North America. The results can be used as an assessment for the industry, to improve practitioner use and knowledge, and to identify further avenues for academic study.Originality/valueThe value of this study lies in filling in identified knowledge gaps on how FM practitioners are using benchmarking in practice. These data are absent from the research literature and offer the potential to help bridge the academic-practitioner divide to ensure that future research will focus on addressing practitioner needs for the industry.
Connectedness between cryptocurrencies, gold and stock markets in the presence of the COVID-19 pandemic
Authors: Ghorbel Achraf , Loukil Sahar , Bahloul Walid 
Published: June 2022

PurposeThis paper analyzes the connectedness with network among the major cryptocurrencies, the G7 stock indexes and the gold price over the coronavirus disease 2019 (COVID-19) pandemic period, in 2020.Design/methodology/approachThis study used a multivariate approach proposed by Diebold and Yilmaz (2009, 2012 and 2014).FindingsFor a stock index portfolio, the results of static connectedness showed a higher independence between the stock markets during the COVID-19 crisis. It is worth noting that in general, cryptocurrencies are diversifiers for a stock index portfolio, which enable to reduce volatility especially in the crisis period. Dynamic connectedness results do not significantly differ from those of the static connectedness, the authors just mention that the Bitcoin Gold becomes a net receiver. The scope of connectedness was maintained after the shock for most of the cryptocurrencies, except for the Dash and the Bitcoin Gold, which joined a previous level. In fact, the Bitcoin has always been the biggest net transmitter of volatility connectedness or spillovers during the crisis period. Maker is the biggest net-receiver of volatility from the global system. As for gold, the authors notice that it has remained a net receiver with a significant increase in the network reception during the crisis period, which confirms its safe haven.Originality/valueOverall, the authors conclude that connectedness is shown to be conditional on the extent of economic and financial uncertainties marked by the propagation of the coronavirus while the Bitcoin Gold and Litecoin are the least receivers, leading to the conclusion that they can be diversifiers.
Exploring the role of environmental literacy and social norms in farmers' LMTT adoption: evidence from China
Authors: Li Songqing , Huo Xuexi , Si Ruishi , Zhang Xueqian , Yao Yumeng , Dong Li 
Published: June 2022

Purpose
Climatic changes caused by greenhouse gases (GHGs) emissions are an urgent challenge for all regions around the globe while the livestock sector is an important source of GHGs emissions. The adoption of low-carbon manure treatment technology (LMTT) by farmers is emerging as an effective remedy to neutralize the carbon emissions of livestock. This paper aims to incorporate environmental literacy and social norms into the analysis framework, with the aim of exploring the impact of environmental literacy and social norms on farmers' adoption of LMTT and finally reduce GHGs emission and climate effects.

Design/methodology/approach
This research survey is conducted in Hebei, Henan and Hubei provinces of China. First, this research measures environmental literacy from environmental cognition, skill and responsibility and describes social norms from descriptive and imperative social norms. Second, this paper explores the influence of environmental literacy and social norms on the adoption of LMTT by farmers using the logit model. Third, Logit model's instrumental approach, i.e. IV-Logit, is applied to address the simultaneous biases between environmental skill and farmers’ LMTT adoption. Finally, the research used a moderating model to analyze feasible paths of environmental literacy and social norms that impact the adoption of LMTT by farmers.

Findings
The results showed that environmental literacy and social norms significantly and positively affect the adoption of LMTT by farmers. In particular, the effects of environmental literacy on the adoption of LMTT by farmers are mainly contributed by environmental skill and responsibility. The enhancement of social norms on the adoption of LMTT by farmers is mainly due to the leading role of imperative social norms. Meanwhile, if the endogeneity caused by the reverse effect between environmental skill and farmers’ LMTT adoption is dealt with, the role of environmental skill will be weakened. Additionally, LMTT technologies consist of energy and resource technologies. Compared to energy technology, social norms have a more substantial moderating effect on environmental literacy, affecting the adoption of farmer resource technology.

Originality/value
To the best of the authors’ knowledge, a novel attempt is made to examine the effects of environmental literacy and social norms on the adoption of LMTT by farmers, with the objective of identifying more effective factors to increase the intensity of LMTT adoption by farmers.
Fraud in startups: what stakeholders need to know
Authors: Gleason Kimberly , Kannan Yezen H. , Rauch Christian 
Published: June 2022

Purpose
This paper aims to explain the fundraising and valuation processes of startups and discuss the conflicts of interest between entrepreneurs, venture capital (VC) firms and stakeholders in the context of startup corporate governance. Further, this paper uses the examples of WeWork and Zenefits to explain how a failure of stakeholders to demand an external audit from an independent accounting firm in early stages of funding led to an opportunity for fraud.

Design/methodology/approach
The methodology used is a literature review and analysis of startup valuation combined with the Fraud Triangle Theory. This paper also provides a discussion of WeWork and Zenefits, both highly visible examples of startup fraud, and explores an increased role for independent external auditors in fraud risk mitigation on behalf of stakeholders prior to an initial public offering (IPO).

Findings
This paper documents a number of fraud risks posed by the “fake it till you make it” ethos and investor behavior and pricing in the world of entrepreneurial finance and VC, which could be mitigated by a greater awareness of startup stakeholders of the value of an external audit performed by an independent accounting firm prior to an IPO.

Research limitations/implications
An implication of this paper is that regulators should consider greater oversight of the startup financing process and potentially take steps to facilitate greater independence of participants in the IPO process.

Practical implications
Given the potential conflicts of interest between VC firms, investment banks and startup founders, the investors at the time of an IPO may be exposed to the risk that the shares of the IPO firms are overvalued at offering.

Social implications
This study demonstrates how startup practices can be extended to the Fraud Triangle and issue a call to action for the accounting profession to take a greater role in protecting the public from startup fraud. This study then offers recommendations for regulators and standards entities.

Originality/value
There are few academic papers in the financial crime literature that link the valuation and culture of startup firms with fraud risk. This study provides a concise explanation of the process of valuation for startups and highlights the considerations for stakeholders in assessing fraud risk. In addition, this study documents an emerging role for auditors as stewards of proper valuation for pre-IPO firms.
A novel neutrosophical approach in stakeholder analysis for sustainable fashion supply chains
Authors: Karadayi-Usta Saliha 
Published: June 2022

PurposeThe purpose of this study is proposing a novel neutrosophical stakeholders' analysis approach for sustainable fashion supply chain (SFSC), presenting a supply chain members and objectives in order to conduct a sustainable business, investigating the roles and positions of these stakeholders, determining the contribution levels of these stakeholders to the sustainability objectives, and accordingly identifying the convergence and divergence among the stakeholders in terms of realization of the objectives.Design/methodology/approachA novel neutrosophic set-based stakeholders' analysis Method of ACTors, Objectives, strength Reports (MACTOR) approach is proposed considering the uncertain and indeterminate opinions of decision-makers. In order to obtain the mutual opinions of decision-makers, Delphi technique is employed.FindingsThe analysis results of this research emphasizes that although the manufacturers can be thought as the foremost actor is SFSC by producing the main product, they have no superior power on conducting the business. Besides, the government, customer and fashion firms are the key players shaping the fashion industry. Retailers and distribution centers can be interpreted as an intermediary in between the other stakeholders. Moreover, the eco-friendly packaging providers have not gained an important role that they were supposed to in terms of the sustainability objectives.Research limitations/implicationsThe application phase of the research includes the possibility of subjective judgments of the participants as a limitation. Therefore, Delphi technique is applied to overcome this challenge by multiple rounds of interviews for panel of participants in order to combine the benefits with elements of the wisdom of people.Practical implicationsExamining a multi-echelon supply chain is a practical implication providing the mutual opinions of experts such as designers, stylists, journalists, consultants, procurement managers, entrepreneurs, activists etc. for sustainability in the fashion industry. One can derive from the findings to determine which sub-echelon requires more attention, or which business is more important to focus on most, or which branch of activity influences others most.Originality/valueThis is one of the few articles that focuses on the sustainability objective and highlights the active roles of all members of the supply chain. Besides, this is the first study deploying neutrosophic sets for MACTOR analysis.
Dynamic characteristics analysis of complex aircraft pipeline system using MDSMA algorithm
Authors: Liu Wei , Zhu Hongyan , Li Wangzhen 
Published: June 2022

PurposeThe dynamic characteristics prediction and frequency-modulation of pipeline was an important work for the design of aircraft hydraulic structure.Design/methodology/approachA complex pipeline was deemed as a combination of several segments of straight-pipe-element (SPE). The 3D vibration equations of each SPE were established in their local coordinate system based on Timoshenko-beam model and Euler-beam model, respectively. The dynamic-stiffness-matrixes were deduced from the dispersion relation of these equations. According to the complex pipeline layout in the global coordinate system, a multi dynamic stiffness matrixes assembling (MDSMA) algorithm was carried out to establish the characteristic equations of the whole complex pipeline. The MDSMA solutions were verified to be consistent with experimental results.FindingsThe MDSMA method based on Timoshenko-Beam model was more suitable for the short span aviation pipeline and the vibration at high frequency stage (>350 Hz). The layout affected the pipeline's in-plane stiffness and out-plane stiffness, for the Z-shaped pipe, each order natural mode took place on the ZP and NP alternately. Reasonable designs of bending position and bending radius were effective means for complex pipeline frequency-modulation.Originality/valueA new dynamic modeling method of aircraft complex pipeline was proposed to obtain the influence of pipeline layout parameters on dynamic characteristics.
The relationship between brand constructs and motivational patterns in crowdfunding decisions. Evidence from university crowdfunding
Authors: Fortezza Fulvio , Checchinato Francesca , Slanzi Debora 
Published: June 2022

Purpose
This study aims to expand the existing body of knowledge on crowdfunding (CF) motivational patterns with special reference to intangible factors, which most scholars assume to be the most important ones, especially in non-investment-based CF. The purpose is to understand how the presence of an established brand in a CF campaign can affect backers’ funding choices and the reasons behind them. To this end, the authors combine principles from identification, brand relationship and self-determination theories.

Design/methodology/approach
The authors considered the (altruistic in nature) domain of CF for social causes as the most widespread type of branded CF and chose the relevant empirical setting of “research CF” run by universities which seem to be more and more interested in connecting branding and fundraising efforts through the active involvement of their “relational circles”. Accordingly, the authors surveyed an extensive sample of students as a primary stakeholder group of potentially engaged backers from one of the first Italian universities to launch a CF program and used structural equation modelling to test the research hypotheses.

Findings
The authors found that, despite the CF domain considered, the choices made by backers (counterintuitively, women, in particular) manifest themselves as mostly self-oriented. This is partly explained by brand identification, which fully mediates the effect of brand pride and partially mediates the effect of brand respect (BR) on funding intention. Moreover, BR also directly drives CF choices.

Originality/value
This study portrays a remarkably different CF playground compared with conventional campaigns for both project proponents and backers with several theoretical and managerial implications.