bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anchor management: a field experiment to encourage families to meet critical programme deadlines
Authors: Moore Ryan T. , Gan Katherine N. , Minnich Karissa , Yokum David 
Published: September 2022

AbstractMany families, despite need and eligibility, struggle to meet programme deadlines to retain critical benefits. When families fail to complete programme recertification on time, they lose needed support. While scholars have tested behavioural theories like chunking, implementation intention, and loss framing to promote programme uptake, less is known about how well-designed communications can promote continuity through successful recertification, especially where recertification entails a significant administrative burden. Further, scant evidence guides how best to frame recertification deadlines. In a randomised trial with government partners (n = 3,539), we find that sending a reminder letter informed by these behavioural theories increased the number of families maintaining participation by 14 per cent. Further, anchoring people to a deadline month may suffice to thread the motivational needle: overcoming procrastination without lowering self-efficacy by anchoring them to a specific day. Adopting the most effective letter in Washington, DC, would lead 766 more families to participate uninterrupted each year.
THE BIRTH OF HOMO ŒCONOMICUS: THE METHODOLOGICAL DEBATE ON THE ECONOMIC AGENT FROM J. S. MILL TO V. PARETO
Authors: Bee Michele , Desmarais-Tremblay Maxime 
Published: September 2022

This paper proposes a genealogy of the concept of homo œconomicus as it emerged from the methodological debate on the economic agent of political economy. If John Stuart Mill gave birth to the economic man in his 1836 essay “On the Definition of Political Economy,” he certainly did not baptize him. The expression was introduced by Francis A. Walker after Mill passed away in the 1870s. Economic man acquired its Latin name of homo œconomicus under the pen of French Catholic economist Claudio Jannet in 1878. Yet, only at the end of the century did Maffeo Pantaleoni (1889) proudly reclaim homo œconomicus as a building block of pure economics. In reaction to the evolutionary hedonism of Pantaleoni, Vilfredo Pareto then cleansed the concept of homo œconomicus and realized the Millian project of an abstract science based on an economic agent.
Future Land Use/Land Cover Change Has Nontrivial and Potentially Dominant Impact on Global Gross Primary Productivity
Authors: Hou Haiyan , Zhou Bing‐Bing , Pei Fengsong , Hu Guohua , Su Zhongbo , Zeng Yijian , Zhang Han , Gao Yukun , Luo Meng , Li Xia 
Published: September 2022

AbstractAnthropogenic land use/land cover (LULC) change alters terrestrial gross primary productivity (GPP), the largest land‐atmosphere carbon exchanges. Identifying the impacts of LULC changes on future terrestrial GPP has been challenging due to the scarcity of standardized future LULC for ecosystem models. Here, we present eight scenario‐based projections of global spatially explicit LULC at 1‐km resolution over the period 2015–2100 with a Future Land Use Simulation model—consistent with the Shared Socioeconomic Pathways and Representative Concentration Pathways. Twenty computational experiments with different LULC patterns, climate forcing, and CO2 concentrations were conducted to quantify their contributions to future GPP dynamics. Results show that the global terrestrial GPP would decline in the 21st century in most LULC scenarios due to urbanization, agricultural expansion, and deforestation. Moreover, the contribution of LULC changes to global GPP dynamics ranges from 3.43% to 10.78% when CO2 fertilization effect (CFE) is not modeled during 2000–2100 (7%–9% of the terrestrial area is dominated by LULC change). However, this value may range from 10.92% to 16.16% during 2000–2050 and 1.41%–14.57% during 2050–2100. The contribution of LULC even reached 56.08% during 2050–2100 in Southeast Asia due to deforestation. Despite the relatively important role of LULC to GPP dynamics, it becomes trivial globally when incorporating CFE into the model (i.e., LULC accounts for 1.24%–2.51% during 2000–2100). Our findings emphasize the strategic role of CFE in enhancing global GPP and highlight the quantitatively nontrivial role of LULC at the regional scale.
Flow Resistance in Very Rough Channels
Authors: Deal E. 
Published: September 2022

AbstractFlow resistance in open channels determines the average flow velocity in a river, with important implications for downstream and at‐a‐station hydraulic geometry and sediment transport in natural channels. However, flow resistance in steep mountain channels is challenging to understand and predict due to heterogeneous channel morphology and spatially variable flow. Using a double‐averaging approach appropriate for very rough channels, the width, reach, and double‐averaged variables for steady, uniform flow in an open channel are derived. Using an empirical model for the coefficient of form drag, a flow resistance model is derived that compares well to a large data set of flow velocity in natural channels. Several parameters that together describe bed morphology are observed to be relatively consistent in the data set used and compare well to previous estimates of their values. This implies a degree of self‐organization in bed morphology that may simplify the challenging problem of predicting flow resistance in steep mountain rivers.
The Importance of Ion Composition for Radiation Belt Modeling
Authors: Ross J. P. J. , Glauert S. A. , Horne R. B. , Meredith N. P. 
Published: September 2022

AbstractThe banded structure of electromagnetic ion cyclotron (EMIC) wave spectra and their resonant interactions with radiation belt electrons depend on the cold ion composition. However, there is a great deal of uncertainty in the composition in the inner magnetosphere due to difficulties in direct flux measurements. Here, we show that the hydrogen and helium band wave spectra are most consistent with a helium and oxygen composition of a few percent. Less than 10% of hydrogen band wave intensity is consistent with a high helium fraction of ∼20%. Similarly, only ∼20% helium band wave intensity is consistent with an oxygen torus ion composition. Furthermore, we find that the decay of the ultra‐relativistic electrons in the radiation belts by EMIC waves depends on the ion composition. The decay is most sensitive to the helium fraction, and the strongest agreement with Van Allen Probes data is found when the helium fraction is a few percent. We suggest that more observations of the cold ion composition would significantly help understand and set constraints on the decay of ultrarelativistic electrons in the radiation belts.
Climate Legacy Effects Shape Tallgrass Prairie Nitrogen Cycling
Authors: Broderick Caitlin M. , Freeman Kiona M. , Zeglin Lydia H. , Blair John M. 
Published: September 2022

AbstractClimate change is expected to shift precipitation regimes in the North American Central Plains with likely impacts on ecosystem functioning. In tallgrass prairies, water and nitrogen (N) can co‐limit ecosystem processes, so changes in precipitation may have complex effects on carbon (C) and N cycling. Rates of N supply such as N mineralization and nitrification respond differently to short‐ and long‐term patterns in water availability, and previous climate patterns may exert legacy effects on current N cycling that could alter ecosystem sensitivity to current precipitation regimes. We used a long‐term precipitation manipulation at Konza Prairie (Kansas, USA) to assess how previous and current precipitation influence tallgrass prairie N cycling. Supplemental irrigation was applied across upland and lowland prairie for ∼25 years to reduce water deficits; in 2017, we reversed some of these treatments and added a reduced rainfall treatment across both historic rainfall regimes, allowing us to assess how previous climate and current rainfall patterns interact to shape N cycling. In lowland prairie, previous irrigation doubled N mineralization and nitrification rates the year following cessation of irrigation. Reduced microbial C:N ratio and lower relative investment in N‐acquiring enzymes in previously irrigated lowlands suggested that a wetter climate created a legacy of increased N availability for microbes. Internal plant N resorption increased under short‐term irrigation but recovered to ambient levels following previous irrigation. Together, these results suggest that a history of wetter conditions can create a legacy of accelerated N cycling, with consequences for both plant and microbial functioning.
LncRNA SEMA3B-AS1 inhibits breast cancer progression by targeting miR-3940/KLLN axis
Authors: Hu Jin , Huang Haohao , Xi Zihan , Ma Shenghui , Ming Jie , Dong Fang , Guo Hui , Zhang Huiqiong , Zhao Ende , Yao Guojie , Yang Liu , Zhang Feng , Zheng Wuping , Chen Hengyu , Huang Tao , Li Lei 
Published: September 2022

AbstractLong noncoding RNAs (lncRNAs) play crucial regulatory roles in the progression of various cancers. However, the functional roles of lncRNAs in breast cancer remain unclear. In this study, we investigated the functional role of a novel long noncoding RNA SEMA3B-AS1 (lncRNA SEAS1) in breast cancer progression and the underlying mechanisms. SEAS1 was downregulated in the triple-negative breast cancer (TNBC) tissues compared with the para-carcinoma tissues, which was associated with poor prognosis of TNBC patients. We demonstrated that SEAS1 knockdown significantly increased the proliferation, migration, and invasion of TNBC cell lines, whereas SEAS1 overexpression reversed these effects. Bioinformatics analysis demonstrated that microRNA (miR)-3940-3p was a potential target of SEAS1. Mechanistically, RNA immunoprecipitation (RIP) and luciferase reporter assays confirmed that lncRNA SEMA3B-AS1 acted as sponge for miR-3940-3p, preventing the degradation of its target gene KLLN, which acts as a tumor-inhibiter in TNBC. Moreover, RNA pulldown, mass spectrometry, ChIP, and luciferase reporter assays confirmed that SMAD3 directly interacted with the promoter of SEAS1 and suppressed its transcription, thereby promoting TNBC progression. The clinical samples of TNBC confirmed SEAS1 was correlated inversely with lymphatic and distant metastasis. In conclusion, our findings reveal a novel pathway for TNBC progression via SMAD3/lncRNA SEAS1/miR-3940-3p/KLLN axis, and suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC.
Clinically relevant pathogens on surfaces display differences in survival and transcriptomic response in relation to probiotic and traditional cleaning strategies
Authors: Hu Jinglin , Shuai Weitao , Sumner Jack T. , Moghadam Anahid A. , Hartmann Erica M. 
Published: September 2022

AbstractIndoor surfaces are paradoxically presumed to be both colonized by pathogens, necessitating disinfection, and “microbial wastelands.” In these resource-poor, dry environments, competition and decay are thought to be important drivers of microbial community composition. However, the relative contributions of these two processes have not been specifically evaluated. To bridge this knowledge gap, we used microcosms to evaluate whether interspecies interactions occur on surfaces. We combined transcriptomics and traditional microbiology techniques to investigate whether competition occurred between two clinically important pathogens,Acinetobacter baumanniiandKlebsiella pneumoniae, and a probiotic cleaner containing a consortium ofBacillusspecies. Probiotic cleaning seeks to take advantage of ecological principles such as competitive exclusion, thus using benign microorganisms to inhibit viable pathogens, but there is limited evidence that competitive exclusion in fact occurs in environments of interest (i.e., indoor surfaces). Our results indicate that competition in this setting has a negligible impact on community composition but may influence the functions expressed by active organisms. AlthoughBacillusspp. remained viable on surfaces for an extended period of time after application, viable colony forming units (CFUs) ofA. baumanniirecovered following exposure to a chemical-based detergent with and withoutBacillusspp. showed no statistical difference. Similarly, forK. pneumoniae, there were small statistical differences in CFUs between cleaning scenarios with or withoutBacillusspp. in the chemical-based detergent. The transcriptome ofA. baumanniiwith and withoutBacillusspp. exposure shared a high degree of similarity in overall gene expression, but the transcriptome ofK. pneumoniaediffered in overall gene expression, including reduced response in genes related to antimicrobial resistance. Together, these results highlight the need to fully understand the underlying biological and ecological mechanisms for community assembly and function on indoor surfaces, as well as having practical implications for cleaning and disinfection strategies for infection prevention.
Patient-reported outcomes from a randomized trial of neoadjuvant atezolizumab-chemotherapy in early triple-negative breast cancer
Authors: Barrios Carlos H. , Saji Shigehira , Harbeck Nadia , Zhang Hong , Jung Kyung H. , Patel Sheetal , Patel Shilpen , Duc Anh Nguyen , Liste-Hermoso Mario , Chui Stephen Y. , Mittendorf Elizabeth A. 
Published: September 2022

AbstractPatient-reported outcomes data assessing patients’ experience of immunotherapy treatment burden in potentially curable early-stage triple-negative breast cancer (TNBC) are lacking. These patient-reported data inform clinical benefit and decision-making for adding atezolizumab to neoadjuvant chemotherapy in early-stage TNBC. IMpassion031 (NCT03197935) randomly assigned patients with stage II/III TNBC (T2–T4d primary tumors) to 5 cycles (4 weeks/cycle) of every 2-week neoadjuvant atezolizumab 840 mg or placebo with weekly nab-paclitaxel (3 cycles) followed by every 2-week dose-dense doxorubicin+cyclophosphamide (2 cycles). After surgery, the atezolizumab-chemotherapy arm received atezolizumab 1200 mg every 3 weeks (11 cycles). The placebo-chemotherapy arm was observed under standard of care. To assess treatment burden from the patients’ perspective, which comprised measures of the treatment-related impact on patients’ functioning and health-related quality of life (HRQoL), as well as patients’ experience of treatment-related symptoms plus their associated bother, patients completed the EORTC QLQ-C30 and FACT-G single-item GP5. Predefined secondary endpoints included mean and mean change from baseline values in the QLQ-C30 function (role and physical) and global health status/quality of life scales. Exploratory endpoints included mean and mean change from baseline in treatment-related symptoms, and treatment side effect bother. Mean physical, role function, and HRQoL were similar between arms at baseline and throughout treatment. In the neoadjuvant period, both arms exhibited clinically meaningful declines of similar magnitude from baseline in physical, role function, and HRQoL, and reported similar treatment side effect to bother at each visit. Improved pathologic complete response from adding atezolizumab to neoadjuvant chemotherapy for early-stage TNBC occurred without imposing additional treatment burden on patients.
Neovascular age-related macular degeneration without exudative recurrence over 24 months after initial remission
Authors: Cho Han Joo , Jeon Young Joon , Yoon Wontae , Yoon Jihyun , Kim Jaemin , Kim Jong Woo 
Published: September 2022

AbstractWe investigated the characteristics of neovascular age-related macular degeneration (AMD), which rarely recurs after initial remission. This study retrospectively analyzed 392 neovascular AMD patients treated with anti-vascular endothelial growth factor (VEGF). All patients received three monthly loading doses of anti-VEGF injections, followed by a pro re nata (as needed) regimen for 24 months. The baseline characteristics associated with the odds of having no recurrence within 24 months were evaluated using multivariate modeling. After the initial three loading injections over 24 months, 58 (14.8%) eyes showed no exudative recurrence and did not require additional anti-VEGF injections. These patients without exudative recurrence had significantly better best-corrected visual acuity (P = 0.003) and lower central subfoveal thickness (P = 0.035) at 24 months than those with exudative recurrence. Additionally, the incidence of macular atrophy was significantly lower in the former than in the latter (8.6% vs. 21.9%; P = 0.020). Multivariate analysis revealed that younger age (odds ratio [OR], 0.901; P = 0.033), smaller lesion size (OR, 0.589; P = 0.016), and absence of fibrovascular pigment epithelial detachment (PED) (OR, 1.349; P = 0.028) were associated with higher odds of no recurrence during follow-up. Approximately 15% of the neovascular AMD patients showed no exudative recurrence after initial remission during the 24-month follow-up. The infrequent recurrence after initial remission correlated with younger age, smaller lesion size, and absence of fibrovascular PED.
Thymol screening, phenolic contents, antioxidant and antibacterial activities of Iranian populations of Trachyspermum ammi (L.) Sprague (Apiaceae)
Authors: Modareskia Mahdieh , Fattahi Mohammad , Mirjalili Mohammad Hossein 
Published: September 2022

AbstractThe seeds of Trachyspermum ammi were gathered at the ripening stage from different regions of Iran and grouped into 14 populations (P1-P14) accordingly. The essential oil (EO) extraction yielded in the 3.16–5% range. EOs were analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC–MS) and 11 constituents were identified. Thymol (59.92–96.4%), p-cymene (0.55–21.15%), γ-terpinene (0.23–17.78%), and carvacrol (0.41–2.77%) were the major constituents. The highest contents of thymol and carvacrol were found in the Ghayen population (P2). Also, P2 and P8 (Estahban) had the highest value of total phenol (TPC) 43.2 mg gallic acid equivalent (GAE)/g DW, and total flavonoids (TFC) 8.03 mg quercetin equivalent (QE)/g DW, respectively. P1 (Kalat) had the highest total coumarin (TCC) value (0.26 mg coumarin equivalent CE/g DW). Based on EO constituents, principal component analysis (PCA) and cluster analysis classified populations into two chemotypes of thymol/p-cymene/γ-terpinene and thymol/carvacrol. The highest positive correlation coefficient was between α-terpinene and limonene (0.96), while the highest negative correlation was between thymol and p-cymene (–0.984). The antioxidant activities of extracts and EOs were evaluated by phosphomolybdenum (total antioxidant capacity; TAC), diphenylpicrylhydrazyl (DPPH IC50), and ferric ion reducing antioxidant power (FRAP) assays. Also, the antimicrobial activity of EOs was studied against Escherichia coli and Staphylococcus aureus. P8 with high thymol, EO content (%v/w), TFC, and antibacterial and antioxidant activities is recommended but further studies are needed to confirm the chemotype introduction.
Epidemiological model based periodic intervention policies for COVID-19 mitigation in the United Kingdom
Authors: Rinaldi Gianmario , Menon Prathyush P. , Ferrara Antonella , Strain W. David , Edwards Christopher 
Published: September 2022

AbstractAs the UK, together with numerous countries in the world, moves towards a new phase of the COVID-19 pandemic, there is a need to be able to predict trends in sufficient time to limit the pressure faced by the National Health Service (NHS) and maintain low hospitalisation levels. In this study, we explore the use of an epidemiological compartmental model to devise a periodic adaptive suppression/intervention policy to alleviate the pressure on the NHS. The proposed model facilitates the understanding of the progression of the specific stages of COVID-19 in communities in the UK including: the susceptible population, the infected population, the hospitalised population, the recovered population, the deceased population, and the vaccinated population. We identify the parameters of the model by relying on past data within the period from 1 October 2020 to 1 June 2021. We use the total number of hospitalised patients and the fraction of those infected who are being admitted to hospital to develop adaptive policies: these modulate the recommended level of social restriction measures and realisable vaccination target adjustments. The analysis over the period 1 October 2020 to 1 June 2021 demonstrates our periodic adaptive policies have the potential to reduce the hospitalisation by 58% on average per month. In a further prospective analysis over the period August 2021 to May 2022, we analyse several future scenarios, characterised by the relaxation of restrictions, the vaccination ineffectiveness and the gradual decay of the vaccination-induced immunity within the population. In addition, we simulate the surge of plausible variants characterised by an higher transmission rate. In such scenarios, we show that our periodic intervention is effective and able to maintain the hospitalisation rate to a manageable level.
A 5-km-thick reservoir with > 380,000 km3 of magma within the ancient Earth's crust
Authors: Latypov Rais , Chistyakova Sofya , Hornsey Richard A. , Costin Gelu , van der Merwe Mauritz 
Published: September 2022

AbstractSeveral recent studies have argued that large, long-lived and molten magma chambers may not occur in the shallow Earth’s crust. Here we present, however, field-based observations from the Bushveld Complex that provide evidence to the contrary. In the eastern part of the complex, the magmatic layering continuously drapes across a ~ 4-km-high sloping step in the chamber floor. Such deposition of magmatic layering implies that the resident melt column was thicker than the stepped relief of the chamber floor. Prolonged internal differentiation within this thick magma column is further supported by evolutionary trends in crystallization sequence and mineral compositions through the sequence. The resident melt column in the Bushveld chamber during this period is estimated at > 5-km in thickness and > 380,000 km3in volume. This volume of magma is three orders of magnitude larger than any known super-eruption in the Earth’s history and is only comparable to the extrusive volumes of some of Earth’s large igneous provinces. This suggests that super-large, entirely molten, and long-lived magma chambers occur, at least occasionally, in the geological history of our planet. Therefore, the classical view of magma chambers as ‘big magma tanks’ remains a viable research concept for some of Earth’s magmatic provinces.
Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue
Authors: Scripture-Adams Deirdre D. , Chesmore Kevin N. , Barthélémy Florian , Wang Richard T. , Nieves-Rodriguez Shirley , Wang Derek W. , Mokhonova Ekaterina I. , Douine Emilie D. , Wan Jijun , Little Isaiah , Rabichow Laura N. , Nelson Stanley F. , Miceli M. Carrie 
Published: September 2022

AbstractIn Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty replacement, and weakness. We develop methodology to efficiently isolate individual nuclei from minute quantities of frozen skeletal muscle, allowing single nuclei sequencing of irreplaceable archival samples and from very small samples. We apply this method to identify cell and gene expression dynamics within human DMD andmdxmouse muscle, characterizing effects of dystrophin rescue by exon skipping therapy at single nuclei resolution.DMDexon 23 skipping events are directly observed and increased in myonuclei from treated mice. We describe partial rescue of type IIa and IIx myofibers, expansion of an MDSC-like myeloid population, recovery of repair/remodeling M2-macrophage, and repression of inflammatory POSTN1 + fibroblasts in response to exon skipping and partial dystrophin restoration. Use of this method enables exploration of cellular and transcriptomic mechanisms of dystrophin loss and repair within an intact muscle environment. Our initial findings will scaffold our future work to more directly examine muscular dystrophies and putative recovery pathways.