bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Green Credit Policy on Inefficient Investment of New Energy Enterprises —— Based on the Dual Perspectives of Resource Allocation and Debt Governance
Authors: Meng Lu , Xu Zhe 
Published: March 2022

Abstract
Based on the perspectives of resource allocation and debt governance, this paper considers a sample of new energy companies from 2008 to 2019 and uses Richardson’s expected investment model to empirically test the relationship between green credit policies and inefficient investment by new energy companies. There is a significant negative relationship between the intensity of green credit policy and the inefficient investment of enterprises, which can both restrain overinvestment and alleviate underinvestment. Through the analysis of the intermediary mechanism, it is found that the green credit policy can optimize the corporate debt maturity structure and reduce agency costs, but the intermediary effect of the debt maturity structure is manifested in the aggravation of overinvestment, and the intermediary effect of agency costs is manifested in a reduction in underinvestment and then inefficient investment. The heterogeneity analysis results show that the resource allocation effect of green credit is more significant in the sample of nonstate-owned enterprises, and the debt governance effect is more significant in the sample of state-owned enterprises.
Circadian Rhythm Promotes the Biomass and Amylose Hyperaccumulation by Mixotrophic Cultivation of Marine Microalga Platymonas Helgolandica
Authors: Shi Qianwen , Chen Cheng , He Tingwei , Fan Jianhua 
Published: March 2022

Abstract
BackgroundMicroalgal starch can be exploitedfor bioenergy, food, and bioplastics. Production of starch by green algae has been concerned for many years. Currently commonly used methods such as nutrient stress will affect cell growth, thereby inhibiting the production efficiency andquality of starchproduction. Simpler and more efficient control strategies need to be developed.ResultWe proposed a novel regulation method to promote the growth and starch accumulation by a new isolated Chlorophyta Platymonas helgolandica. By adding exogenous glucose and controlling the appropriate circadian light and dark time, the highest dry weight accumulation 6.53 g·L-1 (Light: Dark = 12:12) can be achieved, and the highest starch concentration could reach 3.88 g·L-1 (Light: Dark = 6:18). The highest production rate was 0.40 g·L-1·d-1 after 9 days of production. And this method helps to improve the ability to produce amylose, with the highest accumulation of 39.79% DW amylose. We also discussed the possible mechanism of this phenomenon through revealing changes in the mRNA levels of key genes.ConclusionThis study provides a new idea to regulate the production of amylose by green algae. For the first time, it is proposed to combine organic carbonsource addition and circadian rhythm regulation to increase the starchproduction frommarine green alga. A new starch-producing microalga has been developed that can efficiently utilize organic matter and grow without photosynthesis.
Immunoinducible carbon dots-incorporated hydrogel as photothermal-derived antigen depot to trigger robust antitumor immune response
Authors: Liu Suwan , Liu Jingjin , Wu Yunchao , Wang Haoran , Xu Xiao , Li Qianzhe , Yang Mengyu , Gong Aihua , Zhang Miaomiao , Du Fengyi 
Published: March 2022

Abstract
Photothermal therapy (PTT) causes immunogenic tumor cell death (ICD), while fails to elicit a strong anti-tumor immune response partially due to its inherent immunosuppressive microenvironment and low antigen presentation. To address these issues, we developed an immunoinducible carbon dots-incorporated hydrogels (iCD@Gel) through a dynamic covalent Schiff base reaction using mannose modifed aluminum-doped carbon dots (M/A-CDs) as cross-linking agent. The M/A-CDs not only possessed superior photothermal conversion efficiency, but also served as nanocarrier to load CpG ODNs for inducing the maturation of dendritic cells (DCs) via manose receptor-mediated targeting delivery. Upon intratumoral injection, the as-prepared iCD@Gel induced immunogentic tumor cell death and damage-related molecular patterns (DAMPs) release via photothermal ablation under 808 nm NIR irradiation. Subsequently, the iCD@Gel synergized with the DAMPs to significantly promote the maturation and antigen cross-presentation of DCs. Taken together, this work provides a promising strategy to develop nanoparticle-based therapetuic hydrogel for tumor immunotherapy.
What does medical research on Ramadan intermittent fasting tell us? Bibliographic mapping analysis of seven decades (1952–2021) and future directions
Authors: Obaideen Khaled , Shihab Katia Abu , Madkour Mohamed , Faris MoezAlIslam 
Published: March 2022

Abstract
There is a large body of research focused on various aspects related to Ramadan intermittent fasting (RIF) and human health and disease. This study aimed to quantify the bibliometric parameters of RIF medical research over the past seven decades and explore these parameters qualitatively via text mining analysis. We used the Scopus search engine to identify published articles related to RIF from inception to December 31, 2021. All types of research articles were included. Scientometric and bibliometric parameters were determined using Excel, Biblioshiny, and VOSviewer. The Scopus search returned 1916 relevant articles. Most citations pertained to publications from the last two decades, and most publications were original research articles. These publications had received around 27,000 citations, and the 20 most prolific publishing journals had an h-index of 112.25. More than one-third of all medical publications were in open-access journals. There was a 13-fold increase in medical research on RIF over the past few decades. We identified the 10 most prolific publishing countries, institutes, journals, and authors. This is the first comprehensive bibliometric analysis of medical research related to RIF. The research gaps identified will inform future research directions and foster collaborative research activities.
Effect of Variation of Martensite with a Constant Carbon Content on Mechanical Behavior and Sliding Wear of Dual Phase Steels
Authors: Zamani Mehran , Ghasemi Hamid M. , Mirzadeh Hamed 
Published: March 2022

Abstract
In a dual phase (DP) steel, an increase in the martensite volume fraction leads to a decrease in its carbon content, and hence, elucidating the effect of martensite content on the mechanical and tribological behaviors is not possible. For the first time, the present work dealt with this subject by maintaining a constant amount of carbon in different volume fractions of martensite. Tribological properties was evaluated via a pin on disk sliding tribometer. The study of wear tracks and debris revealed oxidative wear as the dominant wear mechanism. Increasing normal load from 10 to 30 N resulted in a decrease in the specific wear rate, which was related to the high work-hardening capacity. This resulted in higher surface hardness, accommodating the formation of a more durable tribofilm on the surface, and a lower coefficient of friction. However, the increase in normal load from 30 N to 60 N resulted in an increase in the specific wear rate and reduction of oxide coverage on the sliding surface due to high surface stresses. The worn debris in the running-in and steady-state stages were mainly identified as metallic and Fe3O4 oxide, respectively.
MALDI-TOF MS-based evaluation for azole-susceptibility testing of Aspergillus fumigatus over reference broth microdilution method
Authors: Araújo Eduardo , Gusmão Norma , Silva Teresinha , Pape Patrice Le , Lima-Neto Reginaldo Gonçalves 
Published: March 2022

Abstract
INTRODUCTION: Azole resistance in Aspergillus fumigatus constitutes an emergency health problem, and the rapid and reliable characterization of this pathogen is essential to guide the appropriate antifungal therapy, techniques based on mass spectrometry, in these cases, could reduce the time of diagnosis in comparison to traditional methods used in hospital routine, with this we intend to establish a protocol to determine the antifungal susceptibility by MALDI TOF MS of Aspergillus fumigatus isolates and correlated with the CLSI guideline. METHODS: Sixteen Aspergillus fumigatus stored at the URM Culture Collection (Brazil) and another at Nantes University (France) were evaluated by the microdilution method in reference broth against itraconazole and voriconazole and the MALDI-TOF MS was used to identify the minimum concentration of change of the protein profile after exposure to the antifungal, the spectra obtained against each concentration were applied to generate composite correlation index (CCI) matrices for each filamentous isolate individually and used to generate heat maps and virtual gel. RESULTS: In this work, the minimum inhibitory concentration by CLSI and the minimum profile change concentration by MALDI-TOF, showed an agreement of 88.2% and 82.4% for itraconazole and voriconazole, respectively. CONCLUSIONS: MALDI-TOF MS is able to determine the cutoff point of susceptibility for Aspergillus fumigatus and allows to predict the best choice of antifungal for patients with invasive aspergillosis.
The Microwave Assisted Reclamation of the Phenolic Cured Butyl Rubber
Authors: Dust Hosein Amoli Vatan , Movahed Saeed Ostad 
Published: March 2022

Abstract
The cured rubber made bladder is used for curing the green tire because, it is thermally stable, and has low gas permeability. The bladder is made with the cured butyl rubber as a base rubber under a phenolic curing system. To save the resources and also the environmental protection, it should be de-crosslink to gum rubber. Several waste bladder rubber compounds prepared with different de-crosslinking agents in formulation. Subsequently, the prepared compounds irradiated in a microwave oven. The de-crosslinking parameters including the sol fraction and de-crosslinking % measured using traditional rubber swollen tests. It revealed that the Fourier transform infrared spectroscopy (FTIR) graphs were suitable evidences to prove the existence of the phenolic resin in the structure of the used waste bladder butyl rubber powder. Efficient de-crosslinking observed for all studied de-crosslinking agents. It was evidenced by the SEM micrographs and also, the measured crosslink densities of the reclaimed rubbers. The highest and the lowest de-crosslinking %’s belonged to the compounds with DPDS and DCBS in formulation, respectively. Based on the obtained de-crosslinking parameters, the DPDS selected as a suitable de-crosslinking agent for the used waste bladder butyl rubber. In accordance with Horikx analysis, the microwave irradiation broke down the crosslinks and rubber main chains simultaneously. The increasing in microwave irradiation temperature had positive effect on the de-crosslinking process but it had equal effect on crosslink and main chain scission.
Application of Logistic Differential Equation Models in Early Warning of Infectious Diseases
Authors: Yang Tianlong , Wang Yao , Yao Laishun , Guo Xiaohao , Hannah Mikah Ngwanguong , Liu Chan , Rui Jia , Zhao Zeyu , Huang Jiefeng , Liu Weikang , Deng Bin , Luo Li , Li Zhuoyang , Li Peihua , Zhu Yuanzhao , Liu Xingchun , Xu Jingwen , Yang Meng , Zhao Qinglong , Su Yanhua , Chen Tianmu 
Published: March 2022

Abstract
Background: There is still a relatively serious disease burden of infectious diseases and the warning time for different infectious diseases before implementation of interventions is important. The logistic differential equation models can be used for predicting early warning of infectious diseases, the aim of this study is to compare the disease fitting effect of the logistic differential equation (LDE) model and the generalised logistic differential equation (GLDE) model, using the two models to calculate the early warning signals of different types of infectious diseases and to solve for disease early warning schedules throughout the year. Methods: Collecting the incidence of 22 infectious diseases in Jilin Province, China. The LDE and GLDE models were used to calculate the recommended warning week (RWW), the epidemic acceleration week (EAW) and warning removed week (WRW) for acute infectious diseases with seasonality, respectively. Results: Five diseases were selected for analysis based on screening principles: hemorrhagic fever with renal syndrome (HFRS), shigellosis, mumps, Hand, foot and mouth disease (HFMD), and scarlet fever. The GLDE model fitted the above diseases better (0.80 ≤ R2 ≤ 0.94, P < 0. 005) than the LDE model. The estimated warning durations (per year) of the LDE model for the above diseases were: weeks 12-23 and 40-50; weeks 20-36; weeks 15-24 and 43-52; weeks 26-34; and weeks 16-25 and 41-50. While the durations of early warning (per year) estimated by the GLDE model were: weeks 7-24 and 36-51; weeks 13-37; weeks 11-26 and 39-54; weeks 23-35; and weeks 12-26 and 40-50. Conclusions: Compared to the LDE model, the GLDE model provides a better fit to the actual disease incidence data. The RWW appeared to be earlier when estimated with the GLDE model than the LDE model. In addition, the WRW estimated with the GLDE model were more lagged and had a longer warning time.
Theoretical study on thermal decomposition mechanism of 1-nitroso-2-naphthol
Authors: Xiaohua FAN , yixiu Gan , Miaowen Tan , wenhe wang 
Published: March 2022

Abstract
1-nitroso-2-naphthol has thermal instability of thermal decomposition, spontaneous combustion and even explosion. Its thermal decomposition characteristics were tested by synchronous thermal analyzer (TGA/DSC); The activation energy of the thermal decomposition process was calculated by Kissinger method; The infrared absorption characteristic spectra of the gas products produced in the thermal decomposition process were measured by TGA/DSC-FTIR, and the thermal decomposition reaction process was speculated. The results show that the initial temperature (Tonset) of TGA exothermic decomposition of 1-nitroso-2 naphthol is between 129.01-155.69℃, and the faster the heating rate(β), the higher the Tonset, but the faster the thermal decomposition rate, the greater the heat release and the worse the thermal stability. The activation energy (E) of the thermal decomposition process is 83.323 kJ/mol calculated by Kissinger method. The dynamic test results of TGA/DSC-FTIR show that the main reaction of 1-nitroso-2 naphthol during heating is intermolecular dehydration to form ether, and the secondary reaction is decomposition into aliphatic nitro compounds, carbonyl compounds and amines. Sodium hydroxide will reduce the thermal stability of 1-nitroso-2 naphthol. After adding sodium hydroxide, the thermal decomposition process of 1-nitroso-2 naphthol has changed. The main reaction is that 1-nitroso-2-naphthol reacts with sodium hydroxide to produce sodium nitrophenol, which is further decomposed into aliphatic nitro compounds.
Neutral Theory: Applicability and Neutrality of Clinical Study Endpoints Where a Disease-Specific Instrument is Available
Authors: Jandhyala Ravi 
Published: March 2022

Abstract
Background:
Disease scoring tools/constructs are designed to accurately measure disease status and severity but are limited by the indicators included and how they are operationalised. Neutral Theory describes the ideal construct that includes all relevant indicators – the Neutral List – and, therefore, provides complete accuracy, or Neutrality. To explore the potential of the theory, indicators from several disease-specific severity scores (DSSs) were assessed as surrogates for the Neutral List.
Methods:
Medline (PubMed) searches were undertaken for 6,804 rare diseases/conditions, listed on the Orphanet database as of 18-Jan-21, to identify those with a single, validated DSS and at least five studies assessing disease severity. The indicators included in each DSS were compared against those utilised in the respective clinical studies and the sensitivity/specificity calculated. The sum of the sensitivity/specificity represented the Neutrality score.
Results:
Ten diseases/conditions met the inclusion criteria: achalasia; Behcet’s syndrome; Creutzfeldt-Jakob disease; Fournier's gangrene; Guillain-Barré syndrome; atypical hemolytic uremic syndrome; palmoplantar psoriasis; Prader-Willi syndrome; systemic lupus erythematosus; and systemic sclerosis. The total number of indicators in the DSSs ranged from 3‒28 and for all diseases/conditions, additional indicators of disease severity were assessed in the clinical studies (1‒36 additional). The Neutrality of the studies across all 10 diseases/conditions varied widely, with achalasia, Fournier’s gangrene, palmoplantar psoriasis, systemic lupus erythematosus, and systemic sclerosis the only diseases with at least one study achieving a maximum Neutrality score of 2. None of the studies for Behcet’s syndrome, Creutzfeldt-Jakob disease, atypical hemolytic uremic syndrome, and Prader-Willi syndrome achieved a Neutrality score > 1.50. Overall, the rate of false negatives increased and the rate of false positives decreased with increasing disease prevalence.
Conclusions:
Across studies of all included diseases/conditions, there was considerable variability in the accuracy or Neutrality of disease severity assessment. Neutral Theory has the potential to improve endpoint definitions and study design and its utility should be explored.
Temporal-Spatial Low Shear Stress Induces Heterogeneity of Hematopoietic Stem Cell Budding in Zebrafish
Authors: Cui Yuliang , Shi Wenpeng , Zhang Kun , Hou Zhengjun , Wang Yanyun , Yan Wenhua , Ma Qinfeng , He Shicheng , Huang Junli , Lu Chenfei , Wang Yeqi , Wang Guixue , Qiu Juhui 
Published: March 2022

Abstract
Hematopoietic stem/progenitor cells (HSPCs) originate from endothelial cells (ECs) localized on the ventral site of the dorsal aorta (DA), and hemodynamic parameters may suffer sharp changes in DA at HSPCs development stage for intersegmental vessel formation. However, the temporal-spatial shear stress parameters and biomechanics mechanisms of HSPC budding remain unknown. Here, we found that the hematopoietic endothelium (HE) in the aorta-gonad-mesonephros was heterogeneous; that is, HEs were mainly distributed at the ventral side of the vascular bifurcation in zebrafish embryos, which was found to show low shear stress (LSS) through numerical simulation analysis. Furthermore, HSPCs localized in the posterior somite of aorta-gonad-mesonephros with slow velocity. On the temporal scale, there was a slow velocity and LSS during HE budding from 36 hours post-fertilization and decreased shear stress with drug expanded HSPC numbers. Mechanistically, matrix metalloproteinase (MMP) expression and macrophage chemotaxis were significantly increased in HEs by RNA-seq. After treatment with an MMP13 inhibitor, HSPCs were significantly reduced in both the aorta-gonad-mesonephros and caudal hematopoietic tissue in embryos. Our results show that HSPC budding is heterogeneous, and the mechanism is that physiological LSS controls the emergence of HSPCs by promoting the accumulation of macrophages and subsequent MMP expression.
Assessment Of Farmers’ Perception Towards Soil And Water Conservation Measures At Bako Tibe District, Western Ethiopia
Authors: Gonde Getu Emiru , Kitila Getahun 
Published: March 2022

Abstract
In Ethiopia, Soil erosion is one of the very chronic environmental problems. It needs attention to carried out conservation measures to tackle the problem and conservation of the environmental resource is the most crucial activities. However, the study on the farmer’s perception towards soil and water conservation measures has not been well investigated in the Bako Tibe district, western Ethiopia. Therefore, this study was undertaken to assess farmer’s perception towards soil and water conservation measures in the study area. The major source of data was a formal household survey. The data was collected by field observation, administer questionnaire, semi structured interview and focus group discussions. The household survey data have been collected and analyzed by utilizing the statistical package for social science (SPSS) version 20.0 Software. The study revealed that farmers of the study area perceived soil erosion as a problem constraining crop production and have knowledge of soil and water conservation measures. The majority of farmers in the study area have the willingness in adoption and conservation of the Soil and Water Conservation. This shows the sustainability of the soil and water conservation in the study area. And also, the farmers stated that they benefited in reducing soil erosion, increase soil fertility, increase crop production and also forage for livestock. The most of farmers of the study area were interested in adoption and conservation of the soil and water conservation structures and majority of them understood the benefits of the conservation in soil erosion control and improve the soil fertility.
Effect of Deficit of budget balance on Private Investment in CEMAC?
Authors: Armand Gilbert Noula , Nguekam Orfé Chouafi , Miamo Clovis , Ongo Emmanuel , AHMED Ali Salim NGNEMADOM 
Published: March 2022

Abstract
This paper aims to determine the impact of the deficit of budget balance on private investment in CEMAC over the period 1984-2019. To this end, the PMG model and the regime-switching model were mobilized to check the linear or non-linear relationship that may exist between the variables involved. At the end of the PMG estimate, it appears that the negative and significant effects of the deficit of budget balance on private investment are not isolated, but depend heavily on its interaction with long-term domestic public debt. Given the non-linear nature of the relationship between deficit of budget balance and private investment, using Hansen's (1999) regime-switching model revealed that there are thresholds for which deficit of budget balance has positive and significant effects on private investment in each CEMAC country. By ricochet, maintaining a sustainable level, the private sector would become the real incubator of the development process in the states.