bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the critical technique of synchronous rotation construction with large angle for T-shape curve rigid frame bridge
Authors: Shao Junhu , Duan Mengjun , Yang Wei , Li YongZhen 
Published: January 2022

AbstractThe superstructure rotation method (SRM) has been widely used in recent years due to its rapid construction, low cost and less impact on existing traffic.This paper focuses on construction method and the key parameters related with large angle synchronous rotation construction of T-shape curved rigid frame bridges, taking two bridges of the Wuyi Expressway over the Chengdu-Kunming Railway as the engineering background.The results show that the construction methods used in this project can accomplish the realization of complexed synchronous rotation execution of T-shape curve rigid frame bridge. The construction methods consist of the installation process of ball joint, the design of traction system, accuracy control method and rotation control strategy.The friction coefficients from practical measurements were compared with the analytical ones from existing formulas, and it shows that the calculation method can give good predictions for the friction coefficients at the SRM of curve rigid frame bridge.Finally, the key technologies and determination of key parameters applicable for large angle synchronous rotation construction of curve T-shape rigid frame bridge are summarized. Furthermore, the research results in this paper can provide technical recommendation for the construction of the similar bridges.
Toxicological assessment of nanocrystalline metal alloys with potential applications in the aeronautical field
Authors: Rumbo Carlos , Bianchin Alvise , Locci Antonio Mario , Barros Rocío , Martel Martín Sonia , Tamayo-Ramos Juan Antonio 
Published: January 2022

AbstractThe development of new candidate alloys with outstanding characteristics for their use in the aeronautical field is one of the main priorities for the sector. In this context, nanocrystaline (nc) alloys are considered relevant materials due to their special features, such as their exceptional physical and mechanical properties. However, another important point that needs to be considered with newly developed alloys is the potential toxicological impact that these materials may have in humans and other living organisms. The aim of this work was to perform a preliminary toxicological evaluation of three nc metal alloys (WCu, WAl and TiAl) in powder form produced by mechanical alloying, applying different in vitro assays, including a mix of W-Cu powders with standard grain size in the experiments to stablish comparisons. The effects of the direct exposure to powder suspensions and/or to their derived leachates were analysed in three model organisms representative of human and environmental exposures (the adenocarcinomic human alveolar basal epithelial cell line A549, the yeast Saccharomyces cerevisiae and the Gram negative bacterium Vibrio fischeri). Altogether, the results obtained provide new insights about the potential harmful effects of the selected nc alloys, showing that, from a toxicological perspective, nc TiAl is the safest candidate in the model organisms and conditions tested.
Bile acids attenuate PKM2 pathway activation in proinflammatory microglia
Authors: Romero-Ramírez Lorenzo , García-Rama Concepción , Wu Siyu , Mey Jörg 
Published: January 2022

AbstractGlycolysis is the metabolic pathway that converts glucose into pyruvate. Central nervous system (CNS) pathologies, such as spinal cord injury (SCI) and ischemia, are accompanied by an increase of the glycolytic pathway in the damaged areas as part of the inflammatory response. Pyruvate kinase is a key glycolytic enzyme that converts phosphoenolpyruvate and ADP to pyruvate and ATP. The protein has two isoforms, PKM1 and PKM2, originated from the same gene. As a homodimer, PKM2 loses the pyruvate kinase activity and acts as a transcription factor that regulates the expression of target genes involved in glycolysis and inflammation. After SCI, resident microglia and hematogenous macrophages are key inducers of the inflammatory response with deleterious effects. Activation of the bile acid receptor TGR5 inhibits the pro-inflammatory NFκB pathway in microglia and macrophages. In the present study we have investigated whether bile acids affect the expression of glycolytic enzymes and their regulation by PKM2. Bacterial lipopolysaccharide (LPS) induced the expression of PKM1, PKM2 and its target genes in primary cultures of microglial and Raw264.7 macrophage cells. SCI caused an increase of PKM2 immunoreactivity in macrophages after SCI. Pretreatment with tauroursodeoxycholic acid (TUDCA) or taurolithocholic acid (TLCA) reduced the expression of PKM2 and its target genes in cell cultures. Similarly, after SCI, TUDCA treatment reduced the expression of PKM2 in the lesion center. These results confirm the importance of PKM2 in the inflammatory response in CNS pathologies and indicate a new mechanism of bile acids as regulators of PKM2 pathway.
A new hyperspectral image classification method based on spatial-spectral features
Authors: Shenming Qu , Xiang Li , Zhihua Gan 
Published: January 2022

AbstractIn recent years, more and more deep learning frameworks are being applied to hyperspectral image classification tasks and have achieved great results. However, the existing network models have higher model complexity and require more time consumption. Traditional hyperspectral image classification methods tend to ignore the correlation between local spatial features. In this paper, a new hyperspectral image classification method is proposed, which combines two-dimensional Gabor filter with random patch convolution (GRPC) feature extraction to obtain spatial-spectral feature information. The method firstly performs dimensionality reduction through principal component analysis and linear discriminant analysis and extracts the edge texture and spatial information of the image using a Gabor filter for the reduced-dimensional image. Next, the extracted information is convolved with random patches to extract spectral features. Finally, the spatial features and multi-level spectral features are fused to classify the images using the Support Vector Machine classifier. In order to verify the performance of this method, experiments were conducted on three widely used datasets of Indian Pines, Pavia University and Kennedy Space Center. The overall classification accuracy reached 98.09%, 99.64% and 96.53%, which are all higher than other comparison methods. The experimental results reveal the superiority of the proposed method in classification accuracy.
Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019
Authors: Nakano Masahito , Yatsuhashi Hiroshi , Bekki Shigemune , Takami Yuko , Tanaka Yasuhito , Yoshimaru Yoko , Honda Koichi , Komorizono Yasuji , Harada Masaru , Shibata Michihiko , Sakisaka Shotaro , Shakado Satoshi , Nagata Kenji , Yoshizumi Tomoharu , Itoh Shinji , Sohda Tetsuro , Oeda Satoshi , Nakao Kazuhiko , Sasaki Ryu , Yamashita Tsutomu , Ido Akio , Mawatari Seiichi , Nakamuta Makoto , Aratake Yoshifusa , Matsumoto Shuichi , Maeshiro Tatsuji , Goto Takashi , Torimura Takuji 
Published: January 2022

AbstractWe examined the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) were analyzed in this prospective study. We divided the study period into four 6-yearly quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV + hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). The incident cases of HCC per quarter of the study period were 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), and 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients < 60 years, 60–69 years, 70–79 years, and ≥ 80 years were 3711 (18.1%), 6652 (32.4%), 7448 (36.2%), and 2736 (13.3%), respectively. The average age of newly-diagnosed patients increased in each quarter. HCC was associated with HBV, HBV + HCV, and HCV infections and non-BC in 2997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased. HCC incident cases tend to increase in the elderly and in non-BC patients; in contrast, HCC incident cases due to HCV tend to decrease.
Characteristics and nutritional value of silkworm (Bombyx mori) pupae-fortified chicken bread spread
Authors: Karnjanapratum Supatra , Kaewthong Pensiri , Indriani Sylvia , Petsong Kantiya , Takeungwongtrakul Sirima 
Published: January 2022

AbstractThis study aimed to apply silkworm pupae (SP) to food product development. The characteristics and sensory acceptance of chicken bread spread fortified with SP at different levels (0%; SP0, 25%; SP25, 50%; SP50, and 75%; SP75) were evaluated. The fat content of the bread spread was significantly increased, whereas the protein content was decreased with increasing levels of SP (p ≤ 0.05). The increased level of SP resulted in the final products being dark in color, as indicated by the significant decrease in L* and the significant increase in a* and b* (p ≤ 0.05). SP50 was accepted by the consumer. Thereafter, the characteristics and sensory acceptance of SP50 with different levels of coconut oil (CO) (100%; SP50-100, 70%; SP50-70, 40%; SP50-40, and 10%; SP50-10 of CO content in the control sample) were studied. The firmness and stickiness increased, whereas TEF decreased with decreasing CO levels, which was related to the decreased spreadability of SP50. SP50-40 obtained satisfactory sensory properties by the consumer. The energy value for SP50-40 was within the normal range for bread spread products. Therefore, SP could be a source of fat and protein for the production of an alternative food product to increase the added value of edible insects.
Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication
Authors: Nakai Masato , Yamamoto Yoshiya , Baba Masaru , Suda Goki , Kubo Akinori , Tokuchi Yoshimasa , Kitagataya Takashi , Yamada Ren , Shigesawa Taku , Suzuki Kazuharu , Nakamura Akihisa , Sho Takuya , Morikawa Kenichi , Ogawa Koji , Furuya Ken , Sakamoto Naoya 
Published: January 2022

AbstractLiver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age ≥ 71 years (hazard ratio [HR]: 3.402) and LSM ≥ 9.2 kPa (HR: 6.328); SVR24 factors were age ≥ 71 years (HR: 2.689) and LSM ≥ 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (≥ 9.2 kPa) and SVR24 LSM (≥ 8.4 kPa) and age (≥ 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up.
High myosin binding protein H expression predicts poor prognosis in glioma patients
Authors: Zhang Jianfei , Guo Qianqiao , Zhang Guoxiang , Cao Xuemei , Chen Wei , Li Yong , Guan Minwu , Yu Jianjun , Wang Xindong , Yan Yujin 
Published: January 2022

AbstractGlioma is the most common and fatal primary brain tumor in humans. Myosin binding protein H (MYBPH), which was first identified as an important myofibrillar constituent of vertebrate skeletal and cardiac muscles, reduces cell motility and metastasis. However, its role in gliomas remains unclear. We evaluated the expression of MYBPH in glioma using Gene Expression Profiling Interactive Analysis (http://gepia.cancer-pku.cn/) and Chinese Glioma Genome Atlas (https://www.cgga.org.cn/). The results showed that MYBPH was highly expressed in glioma tissues. Moreover, MYBPH expression was significantly associated with high tumor aggressiveness and poor outcomes in glioma patients. Mechanistically, the results suggested that MYBPH might promote tumor progression by improving tumor invasion and migration. Our results establish MYBPH as an important prognostic biomarker that could be considered a potential epigenetic and immunotherapeutic target for treatment. We showed that MYBPH is a novel biomarker that is variably expressed in glioblastoma (GBM). The association of high MYBPH expression with poor prognosis in newly diagnosed GBM patients and increased expression in recurrent GBM is indicative of its role in tumor aggressiveness.
The influence of smoke density on hearth location and activity areas at Lower Paleolithic Lazaret Cave, France
Authors: Kedar Yafit , Kedar Gil , Barkai Ran 
Published: January 2022

AbstractWe analyze the influence of hearth location and smoke dispersal on potential activity areas at Lower Paleolithic Lazaret Cave, France, focusing on archaeostratigraphic unit UA25, where a single hearth was unearthed, and GIS and activity area analysis were performed by the excavators. We simulated smoke dispersal from 16 hypothetical hearth locations and analyzed their effect on potential working spaces. Four activity zones were defined, according to the average smoke exposure recommendations from the World Health Organization (WHO) and Environmental Protection Agency (EPA). We found that the size of the low smoke density area and its distance from the hearth are the main parameters for choosing hearth location. The simulation results show an optimal hearth location zone of about 5 × 5m2, and it is precisely in this zone that the Lower Paleolithic humans of Lazaret Cave placed their hearth. We demonstrate that the optimal hearth location zone correlates not only with the archaeological hearth in UA25 but also with the locations of hearths in other layers. In addition, our smoke density analysis confirmed the detailed GIS and activity area reconstruction conducted by the excavators, strongly reinforcing their interpretation regarding the spatial organization of human behavior at Lazaret Cave.
Effects of sound source localization of masking sound on perception level of simulated tinnitus
Authors: Kubota Yamato , Takahashi Kuniyuki , Nonomura Yoriko , Yamagishi Tatsuya , Ohshima Shinsuke , Izumi Shuji , Morita Yuka , Aizawa Naotaka , Horii Arata 
Published: January 2022

AbstractTinnitus therapies have been combined with the use of varieties of sound/noise. For masking external sounds, location of the masker in space is important; however, effects of the spatial location of the masker on tinnitus are less understood. We aimed to test whether a masking sound location would affect the perception level of simulated tinnitus. The 4 kHz simulated tinnitus was induced in the right ear of healthy volunteers through an open-type earphone. White noise was presented to the right ear using a single-sided headphone or a speaker positioned on the right side at a distance of 1.8 m for masking the simulated tinnitus. In other sessions, monaurally recorded noise localized within the head (inside-head noise) or binaurally recorded noise localized outside the head (outside-head noise) was separately presented from a dual-sided headphone. The noise presented from a distant speaker and the outside-head noise masked the simulated tinnitus in 71.1% and 77.1% of measurements at a lower intensity compared to the noise beside the ear and the inside-head noise, respectively. In conclusion, spatial information regarding the masking noise may play a role in reducing the perception level of simulated tinnitus. Binaurally recorded sounds may be beneficial for an acoustic therapy of tinnitus.
Exogenous fatty acids affect membrane properties and cold adaptation of Listeria monocytogenes
Authors: Flegler Alexander , Iswara Janice , Mänz Anna Tatjana , Schocke Frieda Sophia , Faßbender Wanda Antonia , Hölzl Georg , Lipski André 
Published: January 2022

AbstractListeria monocytogenes is a food-borne pathogen that can grow at very low temperatures close to the freezing point of food and other matrices. Maintaining cytoplasmic membrane fluidity by changing its lipid composition is indispensable for growth at low temperatures. Its dominant adaptation is to shorten the fatty acid chain length and, in some strains, increase in addition the menaquinone content. To date, incorporation of exogenous fatty acid was not reported for Listeria monocytogenes. In this study, the membrane fluidity grown under low-temperature conditions was affected by exogenous fatty acids incorporated into the membrane phospholipids of the bacterium. Listeria monocytogenes incorporated exogenous fatty acids due to their availability irrespective of their melting points. Incorporation was demonstrated by supplementation of the growth medium with polysorbate 60, polysorbate 80, and food lipid extracts, resulting in a corresponding modification of the membrane fatty acid profile. Incorporated exogenous fatty acids had a clear impact on the fitness of the Listeria monocytogenes strains, which was demonstrated by analyses of the membrane fluidity, resistance to freeze-thaw stress, and growth rates. The fatty acid content of the growth medium or the food matrix affects the membrane fluidity and thus proliferation and persistence of Listeria monocytogenes in food under low-temperature conditions.
Abnormal data detection of guidance angle based on SMP-SVDD for seeker
Authors: Liang Chao , Cui Dedong , Yan Zhengang , Zhang Xiangyu , Luo Qiang , Hu Jiang , He Xuan 
Published: January 2022

AbstractThe accuracy of the pitch angle deviation directly affects the guidance accuracy of the laser seeker. During the guidance process, the abnormal pitch angle deviation data will be produced when the seeker is affected by interference sources. In this paper, a new abnormal data detection method based on Smooth Multi-Kernel Polarization Support Vector Data Description (SMP-SVDD) is proposed. In the proposed method, the polarization value is used to determine the weight of the multi-kernel combination coefficient to obtain the multi-kernel polarization function, in which the particle swarm optimization is used to find the optimal kernels for higher detection accuracy. Besides, by using smoothing mechanism, the constrained quadratic programming problem is translated to be smooth and differentiable. Then, this problem can be solved by the conjugate gradient method, which could reduce the computational complexity. In experimental section, abundant simulation experiments were designed and the experimental results verify that the proposed SMP-SVDD method could achieve higher detection accuracy and low computational cost compared with different detection methods in different guidance stages.
Analysis of mRNA-derived siRNAs in mutants of mRNA maturation and surveillance pathways in Arabidopsis thaliana
Authors: Krzyszton Michal , Kufel Joanna 
Published: January 2022

AbstractDefects in RNA maturation and RNA decay factors may generate substrates for the RNA interference machinery. This phenomenon was observed in plants where mutations in some RNA-related factors lead to the production of RNA-quality control small interfering RNAs and several mutants show enhanced silencing of reporter transgenes. To assess the potential of RNAi activation on endogenous transcripts, we sequenced small RNAs from a set of Arabidopsis thaliana mutants with defects in various RNA metabolism pathways. We observed a global production of siRNAs caused by inefficient pre-mRNA cleavage and polyadenylation leading to read-through transcription into downstream antisense genes. In addition, in the lsm1a lsm1b double mutant, we identified NIA1, SMXL5, and several miRNA-targeted mRNAs as producing siRNAs, a group of transcripts suggested being especially sensitive to deficiencies in RNA metabolism. However, in most cases, RNA metabolism perturbations do not lead to the widespread production of siRNA derived from mRNA molecules. This observation is contrary to multiple studies based on reporter transgenes and suggests that only a very high accumulation of defective mRNA species caused by specific mutations or substantial RNA processing defects trigger RNAi pathways.
Free surface aeration and development dependence in chute flows
Authors: Wei Wangru , Deng Jun 
Published: January 2022

AbstractThe microscopic description of the mixture behaviour of air–water flow remains a challenge. It is not clear how to represent a complex two-phase interaction with the turbulent air–water structure development process. In this study, based on the air–water mixing fluctuation properties in self-aerated chute flows, a prediction model of air concentration distribution related to a theoretical transition depth is developed. The air–water turbulent mixing analysis reveals that the mixture flow depth, at which the local air concentration is 0.5, represents the interior transition boundary. The agreement of the calculated results with the test data confirms that local water and air turbulent mixing through the free surface area should be equally considered. On the basis of the interior transition depth, the development of self-aeration mainly manifests as the air turbulent mixing process in the low aerated region, while the water turbulent mixing in the high aerated region remains mostly unchanged. A series of relationships concerning the development of self-aerated flows is proposed to enable quantitative estimations in practical applications of water engineering.
Preconceptional paternal alcohol consumption and the risk of child behavioral problems: a prospective cohort study
Authors: Luan Min , Zhang Xiaohua , Fang Guanghong , Liang Hong , Yang Fen , Song Xiuxia , Chen Yao , Yuan Wei , Miao Maohua 
Published: January 2022

AbstractAnimal studies demonstrated that paternal alcohol exposure before conception increases the risk of adverse neurodevelopment in offspring, but limited evidence is known in humans. Based on Shanghai-Minhang Birth Cohort Study, we aimed to examine associations between preconceptional paternal alcohol consumption and child behavioral problems. Paternal alcohol consumption during the last 3 months before conception was obtained by maternal report. Children born to fathers who drank alcohol at least once a week were classified as exposed. Child behavioral problems were assessed using the Child Behavior Checklist (CBCL) at age of 2, 4, and 6. Negative binomial regression was used to estimate the rate ratio (RR) of CBCL raw scores in 796 offspring. The risks of rating scores on anxious/depressed were increased by 33% (RR 1.33, 95% CI 1.09, 1.61) and 37% (RR 1.37, 95% CI 1.02, 1.84) among boys in the exposed group at age of 4 and 6, respectively. We also found that risks of somatic complaints were increased by 18% (RR 1.18, 95%CI 1.00, 1.40) and 65% (RR 1.65, 95%CI 1.14, 2.38) among girls in the exposed group at age of 4 and 6. The increased risks of sleep problems (RR 1.25, 95% CI 1.00, 1.55) in girls at age 4, thought problems (RR 1.32, 95% CI 1.01, 1.73) in girls at age 6, rule-breaking behaviors (RR 1.35, 95% CI 1.09, 1.67) in boys at age 6 were also found. The risks of CBCL scores on anxious/depressed and sleep problems in girls at age 4, as well as the risks of somatic complaints and rule-breaking behaviors in boys at age 6 increased with the level of exposure to paternal alcohol consumption. Our findings provided preliminary evidence that preconceptional paternal alcohol consumption may increase risks of child behavioral problems.