bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensification and Dynamics of the Westward Equatorial Undercurrent During the Summers of 1998 and 2016 in the Indian Ocean
Authors: Huang Ke , Wang Dongxiao , Chen Gengxin , Nagura Motoki , Han Weiqing , McPhaden Michael J. , Feng Ming , Chen Ju , Wu Ying , Zhang Xiaolin , Li Yuanlong , Xie Qiang , Wang Weiqiang , Zhou Feng 
Published: October 2022

AbstractUsing mooring observations and reanalysis, we show that anomalously strong westward Equatorial Undercurrent (wEUC) developed in June–July in 2016 and 1998 in the Indian Ocean, which coincided with extreme Indian Ocean Dipole (IOD) and El Niño events. Simulations show that equatorial Kelvin and Rossby waves were excited by winds associated with El Niño and positive IOD events during 2015 and 1997, and their negative phases during 2016 and 1998. The constructive relationship between the delayed‐time contributions of eastern‐boundary‐reflected‐waves that excited by the easterlies in 2015 and 1997 and the direct contributions of wind‐forced‐waves that excited by the westerlies in 2016 and 1998 resulted in the intensified wEUC. Slow intermediate‐order baroclinic‐modes, rather than fast low‐order baroclinic‐modes, dominated the strong wEUC. The eastern‐boundary‐reflected‐waves dominated in 1997–1998 and directly wind‐forced‐waves dominated in 2015–2016. Our results emphasize the importance of constructive interactions of the directly‐wind‐forced and boundary‐reflected waves in driving the interannual variability of Indian Ocean wEUC.
Chronicle of Processes Leading to the 2018 Eruption at Mt. Etna As Inferred by Seismic Ambient Noise Along With Geophysical and Geochemical Observables
Authors: Büyükakpınar Pınar , Cannata Andrea , Cannavò Flavio , Carbone Daniele , De Plaen Raphael S. M. , Di Grazia Giuseppe , King Thomas , Lecocq Thomas , Liuzzo Marco , Salerno Giuseppe 
Published: October 2022

AbstractThis work analyzes temporal variations of seismic velocities at Mt. Etna from August 2018 to February 2019. During this time period, a strong flank eruption accompanied by intense seismicity and ground deformation took place along a fracture that opened on 24 December 2018 at the base of the New South‐East summit crater. Furthermore, two moderate earthquakes—the 6 October 2018 ML 4.7 and 26 December 2018 ML 4.8—associated with the volcanic activity were recorded. In this study, we computed cross‐correlation functions (CCFs) between windows of seismic ambient noise to identify seismic velocity variations within the volcano edifice. We calculated daily CCFs at 16 stations for 120 interstation pairs using the vertical component in the 1.0–1.5 Hz frequency band. We observe that dv/v starts to decrease rapidly from the beginning of October 2018 and reaches approximately −0.45% in the pre‐eruption period. The spatio‐temporal distribution of seismic velocities shows that the reduction of dv/v mostly occurs in the vicinity of the summit and close to the flank area and is interpreted to be affected by magmatic intrusion at 0–3 km depth. To infer the source mechanism of this eruption, we compared these observations with volcano‐tectonic earthquakes, volcanic tremor, volcanic degassing, gravity, and ground deformation data. Our study suggests that a relationship between magma intrusion and associated crack opening is responsible for the decrease of dv/v.
A 28-day, 2-year study reveals that adolescents are more fatigued and distressed on days with greater NO2 and CO air pollution
Authors: Armstrong-Carter Emma , Fuligni Andrew J. , Wu Xiao , Gonzales Nancy , Telzer Eva H. 
Published: October 2022

AbstractThis 2-year, 28-day study examined whether adolescents felt greater fatigue and emotional distress the same day and the day after air quality was worse. We linked objective daily air quality measurements to daily self-reports from 422 Mexican–American adolescents in Los Angeles County, California from 2009 to 2011 (50% girls, MAge = 15 years). A robust, within-subject analysis of 9696 observations revealed that adolescents with ongoing physical complaints reported greater fatigue and emotional distress on days that the air contained higher levels of nitrogen dioxide (NO2) and carbon monoxide (CO). Regardless of physical complaints, adolescents on average also reported greater fatigue the day after NO2 levels were higher. The same-day and next-day associations between air pollution and distress were mediated via daily increases in fatigue. Results were robust when controlling for day of the week, and daily temperature and humidity. Sulfur dioxide (SO2), ozone (O3), PM2.5 and PM10 were not related to daily fatigue or distress.
Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways
Authors: Granados-Soler José Luis , Taher Leila , Beck Julia , Bornemann-Kolatzki Kirsten , Brenig Bertram , Nerschbach Verena , Ferreira Fernando , Junginger Johannes , Hewicker-Trautwein Marion , Murua Escobar Hugo , Nolte Ingo 
Published: October 2022

AbstractThe molecular heterogeneity of feline mammary carcinomas (FMCs) represents a prognostic and therapeutic challenge. RNA-Seq-based comparative transcriptomic profiling serves to identify recurrent and exclusive differentially expressed genes (DEGs) across sample types and molecular subtypes. Using mass-parallel RNA-Seq, we identified DEGs and performed comparative function-based analysis across 15 tumours (four basal-like triple-negative [TN], eight normal-like TN, and three luminal BfHER2 negative [LBfHER2−]), two cell lines (CL, TiHo-0906, and TiHo-1403) isolated from the primary tumours (LBfHER2−) of two cats included in this study, and 13 healthy mammary tissue controls. DEGs in tumours were predominantly upregulated; dysregulation of CLs transcriptome was more extensive, including mostly downregulated genes. Cell-cycle and metabolic-related DEGs were upregulated in both tumours and CLs, including therapeutically-targetable cell cycle regulators (e.g.CCNB1,CCNB2,CDK1,CDK4,GTSE1,MCM4, andMCM5), metabolic-related genes (e.g.FADS2andSLC16A3), heat-shock proteins (e.g.HSPH1, HSP90B1, andHSPA5), genes controlling centrosome disjunction (e.g.RACGAP1andNEK2), and collagen molecules (e.g.COL2A1). DEGs specifically upregulated in basal-like TN tumours were involved in antigen processing and presentation, in normal-like TN tumours encoded G protein-coupled receptors (GPCRs), and in LBfHER2− tumours were associated with lysosomes, phagosomes, and endosomes formation. Downregulated DEGs in CLs were associated with structural and signalling cell surface components. Hence, our results suggest that upregulation of genes enhancing proliferation and metabolism is a common feature among FMCs and derived CLs. In contrast, the dissimilarities observed in dysregulation of membrane components highlight CLs’ disconnection with the tumour microenvironment. Furthermore, recurrent and exclusive DEGs associated with dysregulated pathways might be useful for the development of prognostically and therapeutically-relevant targeted panels.
Methicillin-resistant staphylococcus aureus nosocomial infection has a distinct epidemiological position and acts as a marker for overall hospital-acquired infection trends
Authors: Samia Noelle I. , Robicsek Ari , Heesterbeek Hans , Peterson Lance R. 
Published: October 2022

AbstractAn ongoing healthcare debate is whether controlling hospital-acquired infection (HAI) from methicillin-resistantStaphylococcus aureus(MRSA) will result in lowering the global HAI rate, or if MRSA will simply be replaced by another pathogen and there will be no change in overall disease burden. With surges in drug-resistant hospital-acquired pathogens during the COVID-19 pandemic, this remains an important issue. Using a dataset of more than 1 million patients in 51 acute care facilities across the USA, and with the aid of a threshold model that models the nonlinearity in outbreaks of diseases, we show that MRSA is additive to the total burden of HAI, with a distinct ‘epidemiological position’, and does not simply replace other microbes causing HAI. Critically, as MRSA is reduced it is not replaced by another pathogen(s) but rather lowers the overall HAI burden. The analysis also shows that control of MRSA is a benchmark for how well all non-S. aureusnosocomial infections in the same hospital are prevented. Our results are highly relevant to healthcare epidemiologists and policy makers when assessing the impact of MRSA on hospitalized patients. These findings further stress the major importance of MRSA as a unique cause of nosocomial infections, as well as its pivotal role as a biomarker in demonstrating the measured efficacy (or lack thereof) of an organization’s Infection Control program.
Interference patterns in ionization of Kramers–Henneberger atom
Authors: Ivanov I. A. , Kheifets A. S. , Kim Kyung Taec 
Published: October 2022

AbstractWe combine IR pump and XUV probe laser pulses to visualize the Kramers–Henneberger (KH) state of the potassium atom. We demonstrate that ionization of such an atom exhibits some molecular-like features such as low order interference maxima in photoelectron momentum spectra. The locations of these maxima allow to estimate spatial dimensions of the KH atom and can be used for accurate calibration of high intensity laser fields. At the same time, we show that an analogy between the KH atom and a homo-nuclear diatomic molecule cannot be extended too far. In particular, higher order interference maxima are very difficult to observe in the case of the KH state. We attribute this to a particular structure of the KH potential which does not confine electron motion to a well-defined potential well unlike in real diatomic molecules.
Using debris disk observations to infer substellar companions orbiting within or outside a parent planetesimal belt
Authors: Stuber T. A. , Löhne T. , Wolf S. 
Published: October 2022

Context. Alongside a debris disk, substellar companions often exist in the same system. The companions influence the dust dynamics via their gravitational potential.
Aims. We analyze whether the effects of secular perturbations, originating from a substellar companion, on the dust dynamics can be investigated with spatially resolved observations.
Methods. We numerically simulated the collisional evolution of narrow and eccentric cold planetesimal belts around a star of spectral type A3 V that are secularly perturbed by a substellar companion that orbits either closer to or farther from the star than the belt. Our model requires a perturber on an eccentric orbit (e ≳ 0.3) that is both far from and more massive than the collisionally dominated belt around a luminous central star. Based on the resulting spatial dust distributions, we simulated spatially resolved maps of their surface brightness in the K, N, and Q bands and at wavelengths of 70 µm and 1300 µm.
Results. Assuming a nearby debris disk seen face-on, we find that the surface brightness distribution varies significantly with observing wavelength, for example between the N and Q band. This can be explained by the varying relative contribution of the emission of the smallest grains near the blowout limit. The orbits of both the small grains that form the halo and the large grains close to the parent belt precess due to the secular perturbations induced by a substellar companion orbiting inward of the belt. The halo, being composed of older grains, trails the belt. The magnitude of the trailing decreases with increasing perturber mass and hence with increasing strength of the perturbations. We recovered this trend in synthetic maps of surface brightness by fitting ellipses to lines of constant brightness. Systems with an outer perturber do not show a uniform halo precession since the orbits of small grains are strongly altered. We identified features of the brightness distributions suitable for distinguishing between systems with a potentially detectable inner or outer perturber, especially with a combined observation with JWST/MIRI in the Q band tracing small grain emission and with ALMA at millimeter wavelengths tracing the position of the parent planetesimal belt.
Are Am stars and hot-Jupiter planets related?
Authors: Saffe C. , Alacoria J. , Miquelarena P. , Petrucci R. , Arancibia M. Jaque , Angeloni R. , Martioli E. , Flores M. , Jofré E. , Collado A. , Gunella F. 
Published: October 2022

Context. Metallic-lined A stars (Am stars) are often components of short-period binary systems, where tidal interactions would result in low rotational velocities and help to develop the chemical peculiarities observed. However, the origin of single Am stars and Am stars that belong to wide binary systems is unclear.
Aims. There is very recent evidence of an Am star hosting a likely synchronized hot brown dwarf (hot BD) and other possible Am stars hosting hot Jupiter planets. Following literature suggestions, we wonder if these hot low-mass companions could play a role in the development of an Am star, that is to say, if they could help to mitigate the “single Am” problem.
Methods. We carried out a detailed abundance determination via spectral synthesis of 19 early-type stars hosting hot BDs and hot Jupiter planets, in order to determine the possible presence of Am stars in this sample. The abundances were determined iteratively for 25 different species by fitting synthetic spectra using the SYNTHE program together with local thermodynamic equilibrium (LTE) ATLAS12 model atmospheres. The abundances of C I, O I, and Mg I were corrected by non-LTE effects. The complete chemical patterns of the stars were then compared to those of Am stars and other chemically peculiar stars.
Results. We studied a sample of 19 early-type stars, seven of them hosting hot BDs and 12 of them hosting hot Jupiter planets. We detected four Am stars in our sample (KELT-19A, KELT-17, HATS-70, and TOI-503) and two possible Am stars (TOI-681 and HAT-P-69). In particular, we detected the new Am star HATS-70, which hosts a hot BD, and we ruled out this class for the hot Jupiter host, WASP-189. Both stars show a different composition than previously reported. For the first time, we estimated the incidence of Am stars among stars hosting hot BDs (50−75%) and among stars hosting hot Jupiters (20−42%). The incidence of Am stars hosting hot BDs has shown to be higher than the frequency of Am stars in general. This would imply that the presence of hot BDs could play a role in the development of Am stars and possibly help to mitigate the single Am problem, which is different for the case of hot Jupiter planets. Notably, these results also indicate that the search for hot BDs may benefit from the targeting of single Am stars or Am stars in wide binary systems. We encourage the analysis of additional early-type stars hosting hot companions in order to improve the significance of the initial trends found here.
Eliciting Information Needs of Child Patients: Adapting the Kano Model to the Design of mHealth Applications
Authors: Müller Sune Dueholm , Tsirozidis Georgios , Mathiasen Morten , Nordenhof Louise , Jakobsen Daniel , Mahler Birgitte 
Published: October 2022

Abstract
Background Health care services are increasingly being digitized, but extant literature shows that digital technologies and applications are often developed without careful consideration of user needs. Research is needed to identify and investigate best-in-class methods to support user-centered design of mHealth applications.
Objectives The article investigates how the Kano model can be adapted and used for the purpose of eliciting child patients' information needs during the design phase of mHealth application development. The aim is to demonstrate its applicability for collecting and analyzing patient-centered data that are key to designing technology-supported solutions for health management.
Methods The article is based on a mixed-methods case study, which includes interviews with 21 patients aged 6 to 18. Structured interviews are analyzed based on prescriptions of the Kano model. Semi-structured interviews about child patients' information needs are analyzed thematically.
Results The results demonstrate several improvements to the Kano model that take into account the difficulties of effectively communicating with child patients. The combination of two types of interviews offers unique insights into the what, how, and why of patients' needs. Adaptation of the Kano model, simplification of response options, and participation of child patients' parents in interviews facilitate data collection.
Conclusion The article shows how the Kano model can be adapted to provide an effective means of eliciting child patients' needs. Adapting the model by combining structured and semi-structured interviews makes it a powerful tool in designing mHealth applications.
Structural Inequities in Medicine that Contribute to Racial Inequities in Asthma Care
Authors: Okelo Sande O. 
Published: October 2022

AbstractStructural inequities in medicine have been present for centuries in the United States, but only recently are these being recognized as contributors to racial inequities in asthma care and asthma outcomes. This chapter provides a systematic review of structural factors such as racial bias in spirometry algorithms, the history of systemic racism in medicine, workforce/pipeline limitations to the presence of underrepresented minority health care providers, bias in research funding awards, and strategies to solve these problems.
Automated Cognitive Health Assessment Using Partially Complete Time Series Sensor Data
Authors: Thomas Brian L. , Holder Lawrence B. , Cook Diane J. 
Published: October 2022

Abstract
Background Behavior and health are inextricably linked. As a result, continuous wearable sensor data offer the potential to predict clinical measures. However, interruptions in the data collection occur, which create a need for strategic data imputation.
Objective The objective of this work is to adapt a data generation algorithm to impute multivariate time series data. This will allow us to create digital behavior markers that can predict clinical health measures.
Methods We created a bidirectional time series generative adversarial network to impute missing sensor readings. Values are imputed based on relationships between multiple fields and multiple points in time, for single time points or larger time gaps. From the complete data, digital behavior markers are extracted and are mapped to predicted clinical measures.
Results We validate our approach using continuous smartwatch data for n = 14 participants. When reconstructing omitted data, we observe an average normalized mean absolute error of 0.0197. We then create machine learning models to predict clinical measures from the reconstructed, complete data with correlations ranging from r = 0.1230 to r = 0.7623. This work indicates that wearable sensor data collected in the wild can be used to offer insights on a person's health in natural settings.
Hyperresponsive Platelets and a Reduced Platelet Granule Release Capacity Are Associated with Severity and Mortality in COVID-19 Patients
Authors: Garishah Fadel Muhammad , Huskens Dana , Pramudo Setyo Gundi , Andriani Dessy , Astrilia Mila , Sentosa Rizky Akbar , van der Ven André J. A. M. , Laat Bas de , Gasem Muhammad Hussein , de Mast Quirijn , Roest Mark 
Published: October 2022

Background Coronavirus disease 2019 (COVID-19) is often associated with mild thrombocytopenia and increased platelet reactivity.
Objective The aim of the current study was to investigate the adenosine triphosphate (ATP) release kinetics of platelets in hospitalized SARS-CoV-2-infected patients.
Methods We studied time-dependent platelet activation in whole blood by monitoring the ATP release kinetics upon stimulation with a PAR1 receptor agonist in 41 hospitalized critically ill COVID-19 patients, 47 hospitalized noncritically ill COVID-19 patients, and 30 healthy controls.
Results Our study demonstrated that platelets of critically ill COVID-19 patients were hyper-responsive with a shorter platelet response time (PRT) and a reduced platelet granule release capacity (GRC), probably due to chronic activation. The median PRT of COVID-19 patients admitted to the critical care unit was 10 and 7 seconds shorter than the median PRT in healthy controls and noncritical COVID-19 patients, respectively. Both PRT and GRC were also associated with D-dimer (Spearman r [r
s] = −0.51, p < 0.0001 and r
s = −0.23, p < 0.05), C-reactive protein (CRP) (r
s = −0.59, p < 0.0001 and r
s = −0.41, p < 0.01), and neutrophil-to-lymphocyte ratio (NLR) (r
s = −0.42, p < 0.0001 and r
s = −0.26, p < 0.05). Moreover, an increased PRT and a reduced GRC were associated with an increased mortality (odds ratio [OR]: 18.8, 95% confidence interval [CI]: 6.5–62.8, p < 0.0001 and OR: 4.0; 95% CI: 1.6–10.4, p < 0.01). These relationships remained significant after adjustment for age, sex, D-dimer, CRP, and NLR.
Conclusion Using an accessible agonist-induced platelet granule ATP release assay, we show that platelet hyper-responsiveness and reduced platelet GRC in COVID-19 patients were associated with critical illness and mortality.
FAST Observations of an Extremely Active Episode of FRB 20201124A. IV. Spin Period Search
Authors: Niu Jia-Rui , Zhu Wei-Wei , Zhang Bing , Yuan Mao , Zhou De-Jiang , Zhang Yong-Kun , Jiang Jin-Chen , Han J. L. , Li Di , Lee Ke-Jia , Wang Pei , Feng Yi , Li Dong-Zi , Luo Rui , Wang Fa-Yin , Dai Zi-Gao , Miao Chen-Chen , Niu Chen-Hui , Xu Heng , Zhang Chun-Feng , Wang Wei-Yang , Wang Bo-Jun , Xu Jiang-Wei 
Published: October 2022

Abstract
We report the properties of more than 800 bursts detected from the repeating fast radio burst (FRB) source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio Telescope during an extremely active episode on UTC 2021 September 25th-28th in a series of four papers. In this fourth paper of the series, we present a systematic search of the spin period and linear acceleration of the source object from both 996 individual pulse peaks and the dedispersed time series. No credible spin period was found from this data set. We rule out the presence of significant periodicity in the range between 1 ms and 100 s with a pulse duty cycle <0.49 ± 0.08 (when the profile is defined by a von-Mises function, not a boxcar function) and linear acceleration up to 300 m s−2 in each of the four one-hour observing sessions, and up to 0.6 m s−2 in all 4 days. These searches contest theoretical scenarios involving a 1 ms–100 s isolated magnetar/pulsar with surface magnetic field <1015 G and a small duty cycle (such as in a polar-cap emission mode) or a pulsar with a companion star or black hole up to 100 M
⊙ and P

b
> 10 hr. We also perform a periodicity search of the fine structures and identify 53 unrelated millisecond-timescale “periods” in multi-components with the highest significance of 3.9σ. The “periods” recovered from the fine structures are neither consistent nor harmonically related. Thus they are not likely to come from a spin period. We caution against claiming spin periodicity with significance below ∼4σ with multi-components from one-off FRBs. We discuss the implications of our results and the possible connections between FRB multi-components and pulsar microstructures.