bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Care Professionals’ Clinical Skills to Address Vaping and e-Cigarette Use by Patients: Needs and Interest Questionnaire Study
Authors: Metcalf Mary , Rossie Karen , Stokes Katie , Tanner Bradley 
Published: February 2022

Background
Widespread vaping and e-cigarette use is a relatively new phenomenon. Youth vaping peaked in 2019, with over 25% of high school students currently vaping. e-Cigarettes are used where smoking is not permitted or as an alternative smoking cessation treatment instead of Food and Drug Administration–approved options. Vaping and e-cigarette use has the potential to harm health, including causing adverse respiratory effects and nicotine addiction. Health care professionals need skills training to help their patients with this relatively new and evolving health problem.

Objective
The aim of this study is to understand health care professionals’ training needs in this subject area to determine the focus for web-based continuing education training.

Methods
We reviewed the literature on clinical aspects of vaping and e-cigarette use. Using the results and our experience in substance use continuing education, we created a list of key clinical skills and surveyed health care professionals about their training needs. We also asked about their interest in a list of related topics. We recruited individuals who completed our web-based courses on substance use, members of health care professional–related groups, and experts who had published an article on the subject. Half of the 31 health care professionals who completed the survey were physicians and the remainder were primarily nurses, social workers, and counselors. Participants self-identified as nonexperts (n=25) and experts (n=6) on vaping.

Results
Participants who were nonexperts on average agreed or strongly agreed that they needed training in each of 8 clinical skills (n=25; range 3.7-4.4 agreement out of 5). The top two skills were recommending treatments for patients (4.4 out of 5, SD 0.49) and evaluating and treating the health effects of vaping and e-cigarette use (4.4 out of 5, SD 0.50). Experts agreed on the importance of training for health care professionals in all skills but rated the need for training higher than nonexperts for each topic. Over half of the participating health care professionals (44%-80%) were interested in nearly all (9/10, 90%) vaping-related topics on a checklist. The topics participants were most interested in were the pros and cons of vaping versus smoking and the health effects of second- and third-hand vaping. Primary care physicians showed more interest in vaping-related topics than nonprimary care physicians (t13=2.17; P=.02).

Conclusions
This study confirmed gaps in health care professionals’ vaping-related clinical skills identified in the literature by identifying a perceived need for training in related skills and health care professionals’ interest in key topics related to vaping prevention and cessation. This study provides specific guidance on which clinical skills training is most needed and which topics are most interesting to health care professionals.
Effectiveness of Individual Feedback and Coaching on Shared Decision-making Consultations in Oncology Care: Protocol for a Randomized Clinical Trial
Authors: van Veenendaal Haske , Peters Loes J , Ubbink Dirk T , Stubenrouch Fabienne E , Stiggelbout Anne M , Brand Paul LP , Vreugdenhil Gerard , Hilders Carina GJM 
Published: February 2022

Background
Shared decision-making (SDM) is particularly important in oncology as many treatments involve serious side effects, and treatment decisions involve a trade-off between benefits and risks. However, the implementation of SDM in oncology care is challenging, and clinicians state that it is difficult to apply SDM in their actual workplace. Training clinicians is known to be an effective means of improving SDM but is considered time consuming.

Objective
This study aims to address the effectiveness of an individual SDM training program using the concept of deliberate practice.

Methods
This multicenter, single-blinded randomized clinical trial will be performed at 12 Dutch hospitals. Clinicians involved in decisions with oncology patients will be invited to participate in the study and allocated to the control or intervention group. All clinicians will record 3 decision-making processes with 3 different oncology patients. Clinicians in the intervention group will receive the following SDM intervention: completing e-learning, reflecting on feedback reports, performing a self-assessment and defining 1 to 3 personal learning questions, and participating in face-to-face coaching. Clinicians in the control group will not receive the SDM intervention until the end of the study. The primary outcome will be the extent to which clinicians involve their patients in the decision-making process, as scored using the Observing Patient Involvement–5 instrument. As secondary outcomes, patients will rate their perceived involvement in decision-making, and the duration of the consultations will be registered. All participating clinicians and their patients will receive information about the study and complete an informed consent form beforehand.

Results
This trial was retrospectively registered on August 03, 2021. Approval for the study was obtained from the ethical review board (medical research ethics committee Delft and Leiden, the Netherlands [N20.170]). Recruitment and data collection procedures are ongoing and are expected to be completed by July 2022; we plan to complete data analyses by December 2022. As of February 2022, a total of 12 hospitals have been recruited to participate in the study, and 30 clinicians have started the SDM training program.

Conclusions
This theory-based and blended approach will increase our knowledge of effective and feasible training methods for clinicians in the field of SDM. The intervention will be tailored to the context of individual clinicians and will target the knowledge, attitude, and skills of clinicians. The patients will also be involved in the design and implementation of the study.

Trial Registration
Netherlands Trial Registry NL9647; https://www.trialregister.nl/trial/9647

International Registered Report Identifier (IRRID)
DERR1-10.2196/35543
Effects of clinical Pilates on the fitness in people with children with disabilities: a randomized controlled trial
Authors: Senturk Yazgi , Kirmizigil Berkiye , Tuzun Emine H 
Published: February 2022

Aim:This study aimed to examine the effects of Clinical Pilates Exercises (CPE) on Health-Related Physical Fitness in Primary Caregivers.Patients & methods:Fifty-five participants were randomly divided into the CPE group and the Control group. Individuals in the CPE group performed CPE two-times a week for 8 weeks.Results:The intergroup comparisons showed that there were significant differences in favor of the CPE group in the sit-up test, body extension endurance, body flexion endurance, side bridge (right), squat test and flexibility tests (p < 0.05). The intragroup comparisons revealed significant differences in the CPE group in the sit-up test, body flexion endurance, side bridge (both sides), squat test and flexibility tests (p < 0.05).Conclusion:CPEs are effective on improvement of health-related fitness parameters in the primary caregivers of children with disabilities.Clinical trial registration number:NCT03729466.
Association of Serum 25-Hydroxyvitamin D With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Prediabetes and Diabetes: Results From the UK Biobank Prospective Cohort Study
Authors: Zhang Peizhen , Guo Dan , Xu Bingyan , Huang Chensihan , Yang Shunyu , Wang Weiwei , Liu Wenhui , Deng Yajuan , Li Kangli , Liu Deying , Lin Jiayang , Wei Xueyun , Huang Yan , Zhang Huijie 
Published: February 2022

OBJECTIVE
To examine the associations of circulating 25-hydroxyvitamin D (25[OH]D) concentrations with cardiovascular disease (CVD) and all-cause mortality in individuals with prediabetes and diabetes from the large population-based UK Biobank cohort study.

RESEARCH DESIGN AND METHODS
A total of 67,789 individuals diagnosed with prediabetes and 24,311 with diabetes who had no CVD or cancer at baseline were included in the current study. Serum 25(OH)D concentrations were measured at baseline. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs for cardiovascular outcomes and mortality after 10–14 years.

RESULTS
After multivariable adjustment, higher serum 25(OH)D levels were significantly and nonlinearly associated with lower risk of cardiovascular outcomes and all-cause mortality among participants with prediabetes and diabetes (all P nonlinearity &lt; 0.05). Compared with those in the lowest category of 25(OH)D levels (&lt;25 nmol/L), participants with prediabetes in the highest category of 25(OH)D levels (≥75 nmol/L) had a significant association with lower risk of cardiovascular events (HR 0.78; 95% CI 0.71–0.86), coronary heart disease (CHD) (HR 0.79; 95% CI 0.71–0.89), heart failure (HR 0.66; 95% CI 0.54–0.81), stroke (HR 0.75; 95% CI 0.61–0.93), CVD mortality (HR 0.43; 95% CI 0.32–0.59), and all-cause mortality (HR 0.66; 95% CI 0.58–0.75). Likewise, these associations with cardiovascular events, CHD, heart failure, CVD mortality, and all-cause mortality were observed among participants with diabetes, except for stroke.

CONCLUSIONS
These findings highlight the importance of monitoring and correcting vitamin D deficiency in the prevention of CVD and mortality among adults with prediabetes and diabetes.
The Effect of Radiotherapy on the Marginal Adaptation of Class II Direct Resin Composite Restorations: A Micro-computed Tomography Analysis
Authors: Oglakci B , Burduroğlu D , Eriş AH , Mayadağlı A , Arhun N 
Published: February 2022

SUMMARY
This laboratory study was designed to evaluate the marginal adaptation of Class II mesio-occlusodistal (MOD) restorations at the cervical region with micro-computed tomography (micro-CT). Two groups of restorations were compared: 1) those that had been exposed to radiotherapy before restoration was performed using a universal adhesive in etch-and-rinse and self-etch modes; and 2) those that had previously been restored using a universal adhesive in etch-and-rinse and self-etch modes and had subsequently undergone radiotherapy.
Sixty intact human molars were randomly divided into groups according to irradiation status: no radiotherapy (control group); radiotherapy followed by restoration (radiotherapy-first group); and restoration followed by radiotherapy (restoration-first group). These three groups were then subdivided into two groups each on the basis of adhesive application type (etch-and-rinse and self-etch modes), for a total of six groups (n=10/group). Standardized Class II MOD cavities were prepared. A universal adhesive (Clearfil Universal Bond Quick, Kuraray, Okayama, Japan) was applied. The teeth were restored with resin composite (Estelite Posterior Quick, Tokuyama, Tokyo, Japan). The radiotherapy protocol was conducted with 60 gray (Gy) at 2 Gy/day, five days a week for six weeks. Adhesive defects were analyzed in distal and mesial views and evaluated with micro-CT (SkyScan 1174v2, Kontich, Antwerp, Belgium) on the basis of the volume of black spaces between the cavity walls and the restorative materials (mm3). The data were analyzed using the Kruskal-Wallis, Mann Whitney U and Wilcoxon tests (p&lt;0.05).
The radiotherapy protocol did not affect the marginal adaptation of the universal adhesive at the cervical regions. Regarding the application modes, for the radiotherapy-first group, the self-etch mode caused significantly higher adhesive defects than the etch-and-rinse mode at the dentin margin. For the no-radiotherapy group, the adhesive defects at the dentin margin were significantly higher than at the enamel margin with the application of the etch-and-rinse mode.
The Gut Microbiota in Epilepsy: Current Concepts of Mechanisms and Potential Therapeutics
Authors: Sulistyo Rikky Dwiyanto 
Published: February 2022

Epilepsy is a non-communicable brain disorder characterized by an individual's proclivity for spontaneous epileptic seizures. Epilepsy may be classified into six types: genetic, structural, metabolic, infectious, immune-related, and unexplained causes. Numerous current findings have shown evidence that an imbalance in the gut microbiota is a cause of epilepsy. Between the gut microbiota and the brain systems, there are five putative communication pathways. The neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis, intestinal bacteria's production of neurotransmitters, the intestinal immune system, and the relationship between the intestinal mucosal barrier and the blood-brain barrier are among them. Future epilepsy interventions might include modifications of antiepileptic medications, a ketogenic diet, and probiotics as a possible treatment in the gut flora. However, further research is required to assess long-term therapeutic benefits.
The Alföld: Denomination and Its Southern Boundary
Authors: Gaudenyi T. , Mihajlović M. 
Published: February 2022

The Alföld with its central position in the Carpathian Basin and eastern position in the Pannonian Plain represents the landscape or physico-geographical unit of Carpathian-Pannonian region.
Following the recommendation of the Hungarian Geographical Society’s Alföld Commission (from 1910) the Alföld should use as a geographic name and the previous denomination “Great Hungarian Plain” should be abandoned. Some parts/segments of the Alföld if use in the context restricted to the national boundaries, the proposed recommendation should be the form of the Alföld with the prefix which according to the country which taking a part of the pointed segment (i.e., in case of Serbia - it should mention: Serbian segment of the Alföld).
The southern boundary of the Alföld is well defined. It is same as SE part of the Pannonian Plain. The south parts of the Alföld encompass the Lower Sava Plain (Donja Posavina), the Tamnava-Kolubara plain, the Velika Morava Plain (Pomoravlje) and the Mlava Plain.
Faktor yang Mempengaruhi Perilaku Mahasiswi Kesehatan dalam Akses Informasi Hak Kesehatan Reproduksi pada Perempuan Disabilitas
Authors: Putri Santy Irene 
Published: February 2022

Background:
The role of health students in providing information about reproductive health is very important, especially regarding reproductive health rights for women with disabilities. This is crucial to do because women with disabilities are very vulnerable to violence and discrimination, especially in terms of reproductive health.
Objectives:
This study aimed to analyze the influence of knowledge and intention toward behavior of female health students in accessing information on reproductive health rights for women with disabilities.
Research Methods:
This was a quantitative study with a cross-sectional design. This study was conducted at the Midwifery Study Program at Tribhuwana Tunggadewi University Malang in October 2020. The sample size was 50 subjects, selected by simple random sampling technique. The dependent variable is the behavior of health female students in accessing information. The independent variables were knowledge and intention in access to information. Data collection using an online questionnaire. The data analysis technique used multiple linear regression.
Results:
The behavior of health female students in access to information was influenced by knowledge (b= 0.36, CI 95% = 0.12 to 0.60, p= 0.005), and intention in access to information (b= 0.45, CI 95% = 0.10 to 0.80, p= 0.014).
Conclusion:
Participants with good knowledge and high intention in access to information affect behavior in accessing information
Penetapan Tarif Ambulans Untuk Evakuasi Medis Berbasis Unit Cost (Penelitian di AGD Dinas Kesehatan DKI Jakarta)
Authors: Riupassa Kelvin E , Nova Narizma , Lestari Endah , Azis Sri Juniarti , Sulistiadi Wahyu 
Published: February 2022

Background:
An ambulance is a vehicle designed to be able to handle emergency patients, provide first aid and carry out intensive care while on the way to a referral hospital. Ambulance operations require a large amount of funds obtained from APBD funds through tariffs that were passed through the DKI Jakarta Governor Regulation five years ago. For this reason, a new tariff is required to adjust to current conditions.
Objectives:
The purpose of this study is to calculate the unit cost of ambulance services in DKI Jakarta to be a consideration in the tariff setting policy in DKI Jakarta province.
Research Metodes:
This study uses a quantitative descriptive approach to obtain information about the unit cost of the Jakarta ambulance production unit. The method used is the calculation of real cost using the basis of the causes of costs. This research was conducted at the DKI Jakarta Emergency Ambulance using secondary data on investment costs, operational costs and maintenance costs in 2018.
Results:
The total cost of emergency ambulance in 2018 is known that the proportion of three cost components, namely operational costs, is 76%, followed by investment costs of 20% and maintenance costs of 3%. The calculation of the total cost of medical evacuation using the double distribution method is Rp. 98,915,016,805.00 divided by the number of medical evacuations in 2018 of 37,564 activities, the unit cost of medical evacuation for the AGD of DKI Jakarta Health Office is Rp. 2,633,215.00 without subsidies. APBD costs, while if the subsidy component is included in the calculation, the unit cost for one trip to the AGD of the Health Office is Rp. 604,071.00. This is still far above the current tariff of Rp. 450.00, so the cost recovery rate (CRR) is still below. 100%.
Conclusion:
From the three cost components consisting of investment, operational and maintenance costs,the largest proportion was operational costs at 76%. The Cost Recovery Rate has not reached 100% so that the existing rates have not covered the costs incurred.
Analisis Faktor Cuaca dengan Kejadian Demam Berdarah Dengue (DBD) di Kabupaten Wonogiri Tahun 2014-2018
Authors: Latifah Endah Nur , Darundiati Yusniar Hanani , Wahyuningsih Nur Endah 
Published: February 2022

Background:
Wonogiri Regency is one of the dengue endemic areas in Central Java with a fluctuating number of cases during 2014-2018. The number of dengue cases drastically increased nearly 4 times amounting 52 cases in 2016 to 207 cases in 2017. Weather factors such as rainfall, humidity, temperature, and wind velocity can affect the reproduction and spread of DHF vectors.
Objectives:
This study was aimed to analyze the association between weather factors (rainfall, humidity, temperature and wind velocity) with the incidence of dengue fever in Wonogiri Regency in 2014-2018.
Research Metodes:
This research was an analytic observational study using cross sectional approach. The type of data used was secondary data about the weather (rainfall, humidity, temperature and wind velocity) in Wonogiri Regency which was obtained from the Wonogiri Meteorological Station and data on the number of dengue incidents in Wonogiri Regency which were obtained from the Health Office of Central Java Province. The data were used each month for 5 years, from January 2014 to December 2018. Data were analyzed by using univariate and bivariate analysis (Rank Spearman correlation test), because only the humidity variable is normally distributed.
Results:
The highest number of dengue cases during 2014-2018 as many as 30 cases in November 2018 with an average of 6 cases, the highest rainfall was 887 mm with an average 191.05 mm, the highest humidity was 91.55% with an average of 86.77%, the highest temperature was 28.75oC with an average of 27.50oC and the highest wind velocity was 7.86 knots with an average of 0.89 knots. The results of the Spearman Rank correlation statistical test showed that there was a significant association with moderate strength and a positive direction between rainfall and the incidence of DHF (p = 0.001 and r = 0.420), which means that the increasing of rainfall, the more the number of DHF incidents. There was no significant association between humidity and the incidence of dengue fever (p = 0.925 and r = 0.012). There is a significant association with moderate strength and a negative direction between temperature and the incident of DHF (p = 0.001 and r = -0.415), which means that the increasing the temperature, the number of dengue cases decreases. There is no significant association between wind velocity and the incident of dengue (p = 0.577 and r = -0.073).
Conclusion:
Rainfall causes the breeding place of Aedes mosquitoes to increase, as a result it has an effect on the increase of the mosquito population. Temperature affects the number of eggs produced by Aedes mosquitoes, so that the density of adult mosquitoes increases.
Relationship between Body Mask Index (BMI) and Titer C-Reactive Protein in Women
Authors: Hari Saktiningsih  , Sulasmi  , Lestari Mastuti Widi 
Published: February 2022

Abstract
Background:
The prevalence of metabolic syndrome is certainly likely to increase with the increasing prevalence of obesity. A reliable indicator and easy-to-use for measuring body fat is body mass index (BMI), in the state of obesity there is a disruption of adiposity balance that is released and as an early marker of inflammation and triggers the formation of C-Reactive protein in the liver.
Objectives:
The goal of the study was to analyze the relationship between BMI and Titer C-Reactive Protein in women..
Research Metodes:
This study is an observational analytical study with a cross sectional approach. The population in this study was women aged 25-65 years. A total of 39 samples were conducted in quota sampling. The data was analyzed with Kendal's tau non parametric test.
Findings:
The results of the study obtained a value of significance or Sig. (2-tailed) 0.908 > 0.05, This result states that there is no relationship between body mass index and titer C-Reactive protein. Correlation coefficient value is -0.015, express a very weak linear relationship. Negative values indicate the opposite direction of the relationship, where the higher the BMI, the lower the C-Reactive protein titer.
Conclusion:
Statistical test results obtained a value of p (0.908) > α (0.05), it states that no significant association between BMI and Titer C-Reactive Protein in women
Mepolizumab-associated acute pancreatitis: a case report
Authors: Casale Fiore , Jan Irum 
Published: February 2022

Background:
Drug hypersensitivity reactions commonly generate systemic syndromes but can also affect specific organs. Mepolizumab, a monoclonal antibody targeting interleukin-5, is a safe and effective Food and Drug Administration-approved biologic therapy for severe eosinophilic asthma.

Case Presentation:
A 49-year-old female developed acute pancreatitis complicated by acute hypoxic respiratory failure secondary to fluid overload. Following 72 hours of intravenous fluids and analgesic administration, an urticarial rash developed on the patient’s trunk, raising concern for a drug-related exanthem. After medication reconciliation, it was deemed that she had a hypersensitivity reaction to mepolizumab.

Conclusion:
In several clinical trials, mepolizumab demonstrated few hypersensitivity reactions. This patient presentation highlights the importance of strong clinical suspicion for drug hypersensitivities, especially in patients failing to respond to the standard of care for common medical conditions.