bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine-Based Learning Shifting to Prediction Model of Deteriorative
MCI Due to Alzheimer’s Disease - A Two-Year Follow-Up Investigation
Authors: Zhao Xiaohui , Sui Haijing , Yan Chengong , Zhang Min , Song Haihan , Liu Xueyuan , Yang Juan 
Published: October 2022

Objective:
The aim of the present work was to investigate the features of the elderly population
aged ≥65 yrs and with deteriorative mild cognitive impairment (MCI) due to Alzheimer’s disease
(AD) to establish a prediction model.

Method:
A total of 105 patients aged ≥65 yrs and with MCI were followed up, with a collection of
357 features, which were derived from the demographic characteristics, hematological indicators (serum
Aβ1-40, Aβ1-42, P-tau and MCP-1 levels, APOE gene), and multimodal brain Magnetic Resonance
Imaging (MRI) imaging indicators of 116 brain regions (ADC, FA and CBF values). Cognitive
function was followed up for 2 yrs. Based on the Python platform Anaconda, 105 patients were randomly
divided into a training set (70%) and a test set (30%) by analyzing all features through a random
forest algorithm, and a prediction model was established for the form of rapidly deteriorating
MCI.

Results:
Of the 105 patients enrolled, 41 deteriorated, and 64 did not come within 2 yrs. Model 1 was
established based on demographic characteristics, hematological indicators and multi-modal MRI image
features, the accuracy of the training set being 100%, the accuracy of the test set 64%, sensitivity
50%, specificity 67%, and AUC 0.72. Model 2 was based on the first five features (APOE4 gene, FA
value of left fusiform gyrus, FA value of left inferior temporal gyrus, FA value of left parahippocampal
gyrus, ADC value of right calcarine fissure as surrounding cortex), the accuracy of the training set
being 100%, the accuracy of the test set 85%, sensitivity 91%, specificity 80% and AUC 0.96. Model
3 was based on the first four features of Model 1, the accuracy of the training set is 100%, the accuracy
of the test set 97%, sensitivity100%, specificity 95% and AUC 0.99. Model 4 was based on the first
three characteristics of Model 1, the accuracy of the training set being 100%, the accuracy of the test
set 94%, sensitivity 92%, specificity 94% and AUC 0.96. Model 5 was based on the hematological
characteristics, the accuracy of the training set is 100%, the accuracy of the test set 91%, sensitivity
100%, specificity 88% and AUC 0.97. The models based on the demographic characteristics, imaging
characteristics FA, CBF and ADC values had lower sensitivity and specificity.

Conclusion:
Model 3, which has four important predictive characteristics, can predict the rapidly deteriorating
MCI due to AD in the community.
Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A
Systematic Review of the Current Literature
Authors: Mosca Alessio , Chiappini Stefania , Miuli Andrea , Mancusi Gianluca , Santovito Maria Chiara , Di Carlo Francesco , Pettorruso Mauro , Corkery John M. , Canessa Carlos , Martinotti Giovanni , Di Giannantonio Massimo 
Published: October 2022

Background:
Ibogaine and noribogaine are psychedelic substances with dissociative properties
naturally occurring in plants of the Apocynaceae family. Research has shown their efficacy in
treating substance use disorders (SUD), particularly in opiate detoxification, but their efficacy and toxicity
are still unclear.

Objective:
This review aims to assess the anti-addictive role of ibogaine and evaluate its side effects.

Methods:
A systematic literature review was conducted on the 29th of November 2021 using PubMed,
Scopus and Web of Science databases through the following search strategy: ("Ibogaine" OR "Noribogaine")
AND ("SUD" OR "substance use disorder" OR "craving" OR "abstinence" OR "withdrawal"
OR "addiction" OR "detoxification") NOT animal NOT review NOT "vitro." The Preferred Reporting
Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed for data gathering
purposes. Research methods were registered on PROSPERO (CRD42021287034).

Results:
Thirty-one articles were selected for the systematic revision, and two were considered for
analysis. The results were organised according to the type of study: case reports/case series, randomised-
controlled trials (RCTs), open-label, survey and observational studies. The main outcomes were
related to the anti-addictive effect of ibogaine and its cardiac toxicity. A meta-analysis of side effects
was conducted using RevMan 5.4 software, showing a significant risk of developing headaches after
ibogaine/noribogaine treatment.

Conclusion:
The results show some efficacy of ibogaine in the treatment of SUDs, but its cardiotoxicity
and mortality are worrying. Further studies are needed to assess its therapeutic efficacy and actual
safety.
Does Folic Acid Supplementation Affect Body Weight or Body Mass
Index? A Systematic Review and Meta-analysis of a Randomized
Controlled Trial
Authors: Aghakhani Ladan , Haghighat Neda , Nazarian Behzad , Clark Cain C. T. 
Published: October 2022

Background & Aims:
Folic acid is a widely used supplement with numerous purported
health benefits. The purpose of this study was to evaluate the effect of folic acid on body
weight (BW) and body mass index (BMI).

Methods:
This systematic review and meta-analysis of 11 randomized controlled trials (RCTs)
evaluated the effects of folic acid supplementation BW or BMI in 514 participants. A systematic
search, current as of March 2021, was performed in PubMed/Medline, Scopus, Web of Science,
and Embase using relevant keywords to identify eligible studies. A fixed-effects model was used
to estimate the weighted mean difference (WMD) and 95% confidence intervals (CIs).

Results:
11 RCTs were included in this meta-analysis. The pooled analysis revealed that folic acid
supplementation did not affect BW (WMD: 0.16 kg; 95% CI: -0.77 to 1.10; p = 0.727, I²=
0.0%, p = 1.00) and BMI (WMD: 0.05 kg/m2; 95% CI: -0.08 to 0.19; p = 0.447, I²= 0.0%, p =
0.666).

Conclusions:
Folic acid supplementation did not significantly impact body weight or BMI. Future
large-scale RCTs, on various dosages and durations of intervention are needed to elucidate the
effects more clearly.
Synthesis and In vivo Evaluation of Hepatoprotective Effects of Novel
Sulfur-Containing 1,4-Dihydropyridines and 1,2,3,4-Tetrahydropyridines
Authors: Dotsenko Victor V. , Krivokolysko Bogdan S. , Bibik Elena Y. , Frolov Konstantin A. , Aksenov Nicolai A. , Aksenova Inna V. , Krivokolysko Sergey G. 
Published: October 2022

Background:
Hepatoprotectors, currently used in clinical practice, often show low efficacy.
One of the promising goals in the therapy of liver diseases is the targeted synthesis of smallmolecule
drugs with hepatoprotective activity. Some heterocycles, such as 1,4-dihydropyridines,
are proven to be good hepatoprotectors.

Objective:
This study aimed to prepare and investigate the hepatoprotective effects of some dihydro-
and tetrahydro pyridines using the experimental rat model of tetrachloromethane (CCl4)-
induced acute liver damage.

Methods:
Several 1,4-dihydropyridines and 1,2,3,4-tetrahydropyridines were synthesized by the
reaction of cyanothioacetamide with carbonyl compounds and active methylene compounds, such
as Meldrum’s acid, ethyl cyanoacetate or β-keto esters, followed by S-alkylation of intermediate
pyridine-2-thiolates. In silico prediction studies were performed to explore the possible protein
targets. Using virtual bioscreening tools, we selected the six most promising compounds from the
library of new partially saturated pyridines. Six novel compounds were characterized by IR, 1H,
13C DEPTQ NMR spectroscopy, 2D NMR experiments (1H–13C HSQC, 1H–13C HMBC), HRMS
(ESI), and elemental analysis. The hepatoprotective effects were studied in vivo on eighty white
rats with CCl4-induced liver damage. Biochemical studies, including thymol turbidity test and
measurements of levels of bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline
phosphatase in the blood of rats, were performed.

Results:
Five of six studied compounds showed a good hepatoprotective effect on a rat model of
tetrachloromethane (CCl4)-induced acute hepatitis. The blood of rats in the experimental groups
revealed significantly lower levels of total bilirubin, alanine aminotransferases, aspartate aminotransferases,
thymol turbidity and alkaline phosphatase compared to the control group of rats
with acute toxic tetrachloromethane hepatitis.

Conclusion:
Our results suggests that compound, (benzyl 4-(4-chlorophenyl)-5-cyano-6-({2-[(3,4-
dimethylphenyl)amino]-2-oxoethyl}thio)-2-methyl-1,4-dihydropyridine-3-carboxylate), can be considered
as candidate for further preclinical studies. Moreover, as per our knowledge, this is the
first report on the hepatoprotective effects of the 1,2,3,4-tetrahydropyridine series.
Cancer Stem Cells and Anti-tumor Immunity
Authors: Yılmaz Merve , Kaplan Fuat , Mender Ilgen , Gryaznov Sergei M. , Dikmen Z. Gunnur 
Published: October 2022

Abstract:
Cancer stem cells (CSCs) are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and formation of metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs, which is important for diagnosis, therapy, and prognosis. This review underlines the role of CSCs and circulating tumor cells (CTCs) in tumor relapse and metastasis, the characteristics of CSC and CTC biomarkers, and the techniques used for the detection of these cells.

We also summarized novel therapeutic approaches toward targeting CSCs, especially focusing on the role of immune checkpoint blockades (ICB), such as anti-programmed death 1 (anti-PD1) and anti-programmed death ligand-1 (anti-PDL1) therapies. Additionally, we address an intriguing new mechanism of action for small molecular drugs, such as telomere targeted therapy 6-thio-2’deoxyguanosine (6-thio-dG), and how it reshapes tumor microenvironment to overcome ICB resistance. There are indications, that, personalized cancer therapy targeting CSC populations in conjunction with immune-mediated strategy hold promise for the removal of residual therapy-resistant CSCs in the near future.
Assessment of Xylem Discs from Fruiting and Shading Plants in Tap
Water Desalination
Authors: Lubbad Said H. , Elfarram Atta 
Published: October 2022

Aims and background:
The low rainwater recharge rate and high seawater intrusion into water aquifer present a dilemma of high ground-water salinity for the narrow coastal Gaza Strip. Thus, extremely saline water causes impairment to household appliances and deteriorates the performance of the reverse-osmosis desalination units.

Methods:
Accordingly, xylem discs of different plants, such as Mulberry, Pomegranate, Olives, Centroza, and Ficus, were investigated for desalination of tap-water by flow-through experimentation. Various parameters such as the total dissolved salt of the inflow water, disc thickness, flow-rate and the type of plant were investigated. Finally, the morphology of the xylem discs of the five plants were screened using optical microscope.

Result and discussion:
It was found that xylem of different plants showed dissimilar efficiencies in water desalination. Thus, Centroza established the highest desalination efficiency of 31%, followed by Olive and Ficus as 26 and 25%, respectively, while Pomegranate and Mulberry established the poorest salt removal of 17 and 14%, respectively. Successive three-disc set up established ~ 50% desalination of inflow-water of ~5000 ppm.

Conclusion:
Hence, disposable cost-effective xylem desalination unit is proposed as guard filter to be installed between the faucet and household desalination units and washing machines or dishwashers, in order to improve the performance and extend the life-time of these appliances.
Overview of 3D and 4D Printing Techniques and their Emerging
Applications in Medical Sectors
Authors: Kumar Rakesh , Kumar Santosh 
Published: October 2022

Abstract:
Additive manufacturing is a highly effective and versatile technology, especially in the
medical sector, due to its customization, material complexity, design flexibility, waste minimization,
and ability to fabricate intricate shapes that are cumbersome to manufacture by conventional
manufacturing techniques. 4D printing plays a significant role in the medical field, especially in
the areas not covered by 3D printing technologies, such as smart implants, devices and tools. Also,
4D printing helps doctors to treat more patients with high accuracy and quality. Hence, this
manuscript aims to provide an overview of distinct 3D and 4D printing techniques and their
emerging applications in the medical sector. A study of 3D printing technologies is presented by
explaining the working principles of distinct 3D printing methods: stereo lithography, fusion deposition
modeling, inkjet printing, selective laser sintering, selective laser melting and electron
beam melting. In addition, the emerging applications of 3D printing in medical sectors (e.g., bioprinting,
surgical guides, pharmaceuticals, prostheses, medical devices, dentistry, physiotherapy,
etc.), as well as challenges and the future scope of 3D printing, are also discussed. Further, the
concept of 4D printing, the market for both 3D and 4D printing, the benefits of 4D printing, the
comparison of 3D and 4D printing, limitations, applications, and the future scope of 4D printing
in the medical sector are also covered.
Mystery of Half-Right Reference
Authors: Dudak Leah 
Published: October 2022

It is common knowledge, in both academic and public libraries, that only 50% of library reference questions are answered correctly. While this statistic continues to be treated as fact - where does it come from, and why do we continue to treat it as fact?
A 1985 study, “Improving Reference Performance: Results of a Statewide Study,” examined the accuracy of reference answers in the Maryland Public Library system and found that 55% of reference questions were answered correctly. However, these results are now outdated, both in time and in interpretation. Some answers that may have been considered incorrect by the study in 1985, like leading a patron to a source or giving a referral, would be considered teaching and correct answers today. As such, the myth half-right reference needs to be recontextualized and reexamined.
Community Collaborations to Identify and Interpret Misinformation
Authors: Dilinika Shalani , Jones Jamaica , Keith Emily , Vaidhyam Sneha 
Published: October 2022

In collaboration with the Carnegie Library of Pittsburgh, a group of PhD students in Library and Information Science at the University of Pittsburgh is hosting Dr. Claire Wardle, co-Founder and co-Director of the Information Futures Lab at Brown University School of Public Health in an online discussion of the role of data across media and journalism ecosystems in the age of online misinformation. This project arose from grant funding awarded through the University of Pittsburgh’s Year of Data and Society, an initiative aiming to “increase… awareness of what socially responsible data practices look like in all domains”.[1]
This event will engage the audience in critical considerations of the ways in which data can be both an investigative tool and the subject of breaking news. It will also create an opportunity for continued discussion about misinformation, the privileges sometimes required to identify misinformation, the role of the media as information gatekeepers and our responsibility in the information professions to become and remain data literate.
[1] University of Pittsburgh. “About.” Year of Data and Society Initiative, 2022. https://pitt.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=06d20b56-b07b-4061-bd76-adcf0034951a.
Using Survival Analysis to Identify Opportunities for Retention of BIPOC Librarians
Authors: Bright Kawanna , VanScoy Amy , Colón-Aguirre Mónica , Kim Sunha 
Published: October 2022

This IMLS-funded project investigates the retention of librarians who identify as Black, Indigenous, and People of Color (BIPOC). The research team will use survival analysis to determine when and why BIPOC librarians are likely to leave the profession. Analysis of quantitative survey data will be paired with interviews to contextualize the results and discussions with key stakeholders. The goal of this project is to identify potential directions for improving retention of BIPOC librarians in the profession. The research questions for the project are:

At what point in their careers do BIPOC librarians tend to leave the profession?
Is there a difference in timing of leaving the profession among different racial/ethnic groups?
Do contextual factors identified in the literature, such as mentoring and discrimination influence the probability of leaving the profession? If they do, how do the factors work differently for the BIPOC and non-BIPOC groups?
How have the patterns of retention of BIPOC librarians changed over the last decade?

Knowing what causes BIPOC librarians to leave the profession and when this occurs can lead to improved retention plans for individual libraries and professional associations that will allow for the creation of programs that can bring support to BIPOC librarians when needed. The findings will equip supervisors and professional associations with knowledge that will help make their retention efforts more specific and their interventions timelier and more effective. The findings will allow for more targeted retention programs that will provide the right support at the right time.
So You Think You Won’t Be A Supervisor?
Authors: Crumpton Michael , DePolt Joanna 
Published: October 2022

Collaboration between faculty, faculty practitioners, and practitioners enhances teaching and research opportunities, provides more hands-on learning opportunities, and improves the knowledge and experience of all of those involved. Students benefit from learning about real world scenarios to couple with theoretical knowledge. Such experience improves student outcomes and informs their professionalism. Practitioners bring value added to the department with real-time information on new practices, trends, and solutions. Administrations recognize this value added and are striving to foster more inclusivity. Collaboration builds more resiliency into LIS programs and encourages the development of new leaders in our classrooms.
Most LIS programs include a management course and usually required. Anecdotally many students react to the course with a distain or non-preference for supervisory work and self-identify as not expecting to move into management or supervision. Many course designs include an assignment meant to have students interact with practicing library supervisors or managers in order to learn through that lens.
This panel will encourage participants to think critically about the role of practitioners in LIS education, with a particular emphasis on preparing students for future roles in administration. Practitioners, whether as adjunct faculty, guest speakers, or full-time lecturers, bring greater emphasis to the lived experiences of the field to the classroom. This blend of current research with current experience offers a more holistic program to the student. Both administrators and accrediting agencies recognize the depth this blend brings to departments as evidenced by shifting attitudes and the development of greater support.
This panel will discuss:

Resilience and leadership in action
The concept of capacity and the impact on leadership effectiveness
Discussion of data collected from current practitioners through interviews conducted by current LIS students under the guidance of practitioner educators
Exploration of resilience and leadership in library administrations during the challenges of COVID (2020-2022)
Preparing Library and Information Science (LIS) Students for Scholarly Communication Librarianship
Authors: Tmava Ahmet 
Published: October 2022

A growing number of academic librarians have been responsible for scholarly communication (SC) roles and responsibilities, and other related services. Previous studies (Finlay, et al., 2015) show an increase in job opportunities for librarians with SC expertise. Eighty-four percent of the students in the Hollister (2017) study described the SC as either relevant or very relevant to their career goals. However, a recent search (2021) within ALA accredited programs in Library and Information Science (LIS) reveals that only 6 out 48 offer a course in scholarly communication, and no program offered a course on related areas. Given a growing demand for wide range of SC services it is imperative for LIS programs to prepare students for these emerging new roles and responsibilities. To that end, I developed a course on SC and other related concepts based on the North American Serials Interest Group (NASIG) core competencies for SC librarians and the SC common responsibilities identified in previous studies (Hackstadt, 2020). This study will explore the extent to which the course addresses the core competencies for SC roles and responsibilities. The study will employ a self-assessment survey designed to measure the difference in students’ knowledge pre and post course completion regarding the SC core competencies. The NASIG core competencies for SC librarians align with roles and responsibilities of SC librarians as described in previous studies. Therefore, the focus on NASIG core competencies makes the results from this study broadly useful for instructors of SC courses.
Narratives of School Library Education and Research
Authors: Morris Rebecca , Reinsel Soulen Rita , Shasteen Ruth , Steiger Sarah , Santos Green Lucy , Johnston Melissa 
Published: October 2022

Researchers will share two papers exploring School Library topics interpreting the 2022 conference theme, Go Back and Get It: From One Narrative to Many. This interactive SIG session includes the presentation of papers, followed by open dialogue regarding issues raised by the papers, potential implications for practice and research, and future areas for research and collaboration. The 2022 session will include the following presentations:
iSchool/CPS Cohort: Partnership Model for Increasing Diversity and Cultural Relevance in School Librarianship. Through a dynamic and committed partnership between the Chicago Public Schools’ Department of Curriculum, Instruction and Digital Learning and the School of Information Sciences in the University of Illinois Urbana-Champaign, the iSchool/CPS cohort of 20 diverse Chicago Public Schools’ content area classroom educators was recruited to complete requirements for adding the Illinois Library Information Specialist endorsement to their teaching licenses. This project is a shared commitment to our roles in advocating for certified school librarians in Illinois schools, focused on developing workforce skills, recruiting diverse representation to school librarianship, and meeting the needs of the students in Illinois.
Upending Systems of Injustice: Educating Future School Library Researchers on Ethical Publishing for Scholarly Research. Publicly available publication ethics guidelines and policies are vital in creating a transparent process that prevents unethical research, publication misconduct, manipulation of the communication of research to practitioners, and the erosion of public trust. This study investigated how these unethical practices, specifically those coded as editorial misconduct, bring the authenticity and integrity of the library and information science academic research digital record into question. Employing a multi-layered approach, including key informant interviews, researchers determined the frequency and the content of ethical publishing policies and procedures in library and information science journals; exploring the ways editorial misconduct most severely impacted library and information science researchers of color, and school library researchers. Findings were used to develop recommendations for school library educators and practitioners facing these issues.