bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic evaluation of the Target-D platform to match depression management to severity prognosis in primary care: A within-trial cost-utility analysis
Authors: Lee Yong Yi , Mihalopoulos Cathrine , Chatterton Mary Lou , Fletcher Susan L. , Chondros Patty , Densley Konstancja , Murray Elizabeth , Dowrick Christopher , Coe Amy , Hegarty Kelsey L. , Davidson Sandra K. , Wachtler Caroline , Palmer Victoria J. , Gunn Jane M. 
Published: May 2022

Background
Target-D, a new person-centred e-health platform matching depression care to symptom severity prognosis (minimal/mild, moderate or severe) has demonstrated greater improvement in depressive symptoms than usual care plus attention control. The aim of this study was to evaluate the cost-effectiveness of Target-D compared to usual care from a health sector and partial societal perspective across 3-month and 12-month follow-up.

Methods and findings
A cost-utility analysis was conducted alongside the Target-D randomised controlled trial; which involved 1,868 participants attending 14 general practices in metropolitan Melbourne, Australia. Data on costs were collected using a resource use questionnaire administered concurrently with all other outcome measures at baseline, 3-month and 12-month follow-up. Intervention costs were assessed using financial records compiled during the trial. All costs were expressed in Australian dollars (A$) for the 2018–19 financial year. QALY outcomes were derived using the Assessment of Quality of Life-8D (AQoL-8D) questionnaire. On a per person basis, the Target-D intervention cost between $14 (minimal/mild prognostic group) and $676 (severe group). Health sector and societal costs were not significantly different between trial arms at both 3 and 12 months. Relative to a A$50,000 per QALY willingness-to-pay threshold, the probability of Target-D being cost-effective under a health sector perspective was 81% at 3 months and 96% at 12 months. From a societal perspective, the probability of cost-effectiveness was 30% at 3 months and 80% at 12 months.

Conclusions
Target-D is likely to represent good value for money for health care decision makers. Further evaluation of QALY outcomes should accompany any routine roll-out to assess comparability of results to those observed in the trial. This trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12616000537459).
Multilevel analysis of predictors of multiple indicators of childhood vaccination in Nigeria
Authors: Aheto Justice Moses K. , Pannell Oliver , Dotse-Gborgbortsi Winfred , Trimner Mary K. , Tatem Andrew J. , Rhoda Dale A. , Cutts Felicity T. , Utazi C. Edson 
Published: May 2022

Background
Substantial inequalities exist in childhood vaccination coverage levels. To increase vaccine uptake, factors that predict vaccination coverage in children should be identified and addressed.

Methods
Using data from the 2018 Nigeria Demographic and Health Survey and geospatial data sets, we fitted Bayesian multilevel binomial and multinomial logistic regression models to analyse independent predictors of three vaccination outcomes: receipt of the first dose of Pentavalent vaccine (containing diphtheria-tetanus-pertussis, Hemophilus influenzae type B and Hepatitis B vaccines) (PENTA1) (n = 6059) and receipt of the third dose having received the first (PENTA3/1) (n = 3937) in children aged 12–23 months, and receipt of measles vaccine (MV) (n = 11839) among children aged 12–35 months.

Results
Factors associated with vaccination were broadly similar for documented versus recall evidence of vaccination. Based on any evidence of vaccination, we found that health card/document ownership, receipt of vitamin A and maternal educational level were significantly associated with each outcome. Although the coverage of each vaccine dose was higher in urban than rural areas, urban residence was not significant in multivariable analyses that included travel time. Indicators relating to socio-economic status, as well as ethnic group, skilled birth attendance, lower travel time to the nearest health facility and problems seeking health care were significantly associated with both PENTA1 and MV. Maternal religion was related to PENTA1 and PENTA3/1 and maternal age related to MV and PENTA3/1; other significant variables were associated with one outcome each. Substantial residual community level variances in different strata were observed in the fitted models for each outcome.

Conclusion
Our analysis has highlighted socio-demographic and health care access factors that affect not only beginning but completing the vaccination series in Nigeria. Other factors not measured by the DHS such as health service quality and community attitudes should also be investigated and addressed to tackle inequities in coverage.
APONTAMENTOS TEÓRICOS DA FENOMENOLOGIA COMO (POSSÍVEL) CAMINHO METODOLÓGICO PARA PESQUISAS EM EDUCAÇÃO NÃO ESCOLAR
Authors: Vianna Ferreira Arthur 
Published: May 2022

O presente artigo tem como objetivo discutir como a ﬁ losoﬁ a fenomenológica de Edmund Husserl (1958; 1975) pode servir de inspiração à construção de um caminho epistemológico para pesquisas sobre práticas educativas em espaços não escolares. Para isso, traz a reﬂ exão de alguns autores a respeito dessa ﬁ losoﬁ a, como Salansky (2006), Depraz (2011) e Ferreira (2015) e, particularmente, o desenvolvimento de três conceitos considerados relevantes para a análise da realidade educacional como um fenômeno social: o noema, a noese e a variação eidética como doação de sentido da realidade pelos sujeitos dos processos de ensino-aprendizagem. Ao ﬁ nal, o artigo mostra o emprego desses aspectos da Fenomenologia e seus resultados em algumas pesquisas sobre educação e pobreza que utilizaram esse percurso metodológico.
Análise dos fatores de Atração e retenção de profissionais médicos da estratégia da saúde da família na região oeste de Minas Gerais
Authors: Soares Cíntia 
Published: May 2022

O objetivo deste artigo foi identificar fatores que facilitam a atração e a retenção dos profissionais médicos na Estratégia de Saúde da Família (ESF) em municípios da região oeste de Minas Gerais.Através de metodologia descritiva qualitativa, os resultados encontrados apontam como fatores de atração para o trabalho na ESF: identificação com o tipo de trabalho, porta de entrada no mercado de trabalho enquanto se aguarda a residência, admiração pelo tipo de trabalho e incentivo para esta área desde a graduação. Os fatores de retenção identificados foram a percepção da remuneração, compatibilidade com outra atividade remunerada; satisfação profissional; vínculo na contratação; curso de formação e aperfeiçoamento; estado civil; forma de ingresso; faixa etária; tempo de formado; quantidade de filhos. Os fatores de não retenção foram: oferta de emprego com melhor remuneração, entrada na residência e falta de valorização da ESF. Os resultados apontam a necessidade de se refletir sobre as diferentes ações públicas visando tanto fortalecimento da estratégia de saúde quanto de medidas voltadas à gestão de profissionais de saúde que favoreçam sua atração e retenção neste modelo.
Enfermagem na APS: contribuições, desafios e recomendações para o fortalecimento da Estratégia Saúde da Família
Authors: Nunciaroni Andressa Teoli , Cunha Carlos Leonardo Figueiredo , Borges Flávio Adriano , Souza Inês Leoneza de , Koster Isabella , Souza Isadora Siqueira de , Silva Lucélia dos Santos , Ferreira Sandra Rejane Soares 
Published: May 2022

Esta Nota Técnica foi produzida no âmbito da Rede de Pesquisa em Atenção Primária à Saúde da Associação Brasileira de Saúde Coletiva (Abrasco) com o propósito de colaborar para o desenvolvimento da agenda estratégica da Rede. Participaram de sua elaboração representantes da Associação Brasileira de Enfermagem de Família e Comunidade (Abefaco) e Associação Brasileira de Enfermagem (ABEn).
O documento com a temática Enfermagem na Atenção Primária à Saúde (APS) faz parte de um conjunto de outras notas da Rede e tem por objetivos: apresentar um retrato sobre a atuação da Enfermagem e suas contribuições para o fortalecimento da Estratégia Saúde da Família (ESF) no Brasil; e tecer recomendações que permitam o seu desenvolvimento, a partir dos elementos críticos do contexto atual do país que interferem nas atividades profissionais.
Ao longo do tempo, a Enfermagem apresenta uma participação sociopolítica importante na construção da APS, em conjunto com as demais profissões da área da saúde. Sua atuação exibe elementos significativos que colaboram com o desenvolvimento dos atributos da APS, sobretudo se tomar a ESF como modelo prioritário para o Sistema Único de Saúde (SUS). Contudo, destaca-se que a profissão, apesar de seus esforços, devido à estrutura sociopolítica e econômica, ainda não obteve o reconhecimento e a visibilidade merecidos.
A partir dessa produção, alguns pontos-chave podem ser destacados:

A centralidade da ESF como modelo prioritário para uma Política Nacional de Atenção Básica (PNAB) que fortaleça a APS e a universalidade do SUS.
A Enfermagem na contribuição e consolidação da ESF pela amplitude de áreas de atuação e escopo de práticas.
A estrutura social, política e econômica, que traz implicações diretas à Enfermagem, com prejuízo para o seu desenvolvimento, relacionado à gestão do trabalho, formação, atuação e reconhecimento social.
A PNAB de 2017, que trouxe repercussões críticas para o processo de trabalho das equipes de saúde da família (eSFs), assim como para a Enfermagem.
A compreensão de que o campo da gestão do trabalho e educação na saúde, a participação sociopolítica da Enfermagem e o fortalecimento de sua especialidade na APS podem impulsionar a agenda estratégica da Rede de Pesquisa em APS da Abrasco, assim como outras iniciativas.
A relevância em alcançar os Objetivos de Desenvolvimento Sustentável (ODS) na atuação profissional pelas eSFs.
Discontinuous Petrov–Galerkin Approximation of Eigenvalue Problems
Authors: Bertrand Fleurianne , Boffi Daniele , Schneider Henrik 
Published: May 2022

Abstract
In this paper, the discontinuous Petrov–Galerkin approximation of the Laplace eigenvalue problem is discussed.
We consider in particular the primal and ultraweak formulations of the problem and prove the convergence together with a priori error estimates.
Moreover, we propose two possible error estimators and perform the corresponding a posteriori error analysis.
The theoretical results are confirmed numerically, and it is shown that the error estimators can be used to design an optimally convergent adaptive scheme.
Comprehensive narrative review of real-world COVID-19 vaccines: viewpoints and opportunities
Authors: Liu Shelan , Kang Min , Zhao Na , Zhuang Yali , Li Shijian , Song Tie 
Published: May 2022

Abstract
Currently, people all over the world have been affected by coronavirus disease 2019 (COVID-19). Fighting against COVID-19 is the top priority for all the countries and nations. The development of a safe and effective COVID-19 vaccine is considered the optimal way of ending the pandemic. Three hundred and 44 vaccines were in development, with 149 undergoing clinical research and 35 authorized for emergency use as to March 15 of 2022. Many studies have shown the effective role of COVID-19 vaccines in preventing SARS-CoV-2 infections as well as serious and fatal COVID-19 cases. However, tough challenges have arisen regarding COVID-19 vaccines, including long-term immunity, emerging COVID-19 variants, and vaccine inequalities. A systematic review was performed of recent COVID-19 vaccine studies, with a focus on vaccine type, efficacy and effectiveness, and protection against SARS-CoV-2 variants, breakthrough infections, safety, deployment and vaccine strategies used in the real-world. Ultimately, there is a need to establish a unified evaluation standard of vaccine effectiveness, monitor vaccine safety and effectiveness, along with the virological characteristics of SARS-CoV-2 variants; and determine the most useful booster schedule. These aspects must be coordinated to ensure timely responses to beneficial or detrimental situations. In the future, global efforts should be directed toward effective and immediate vaccine allocations, improving vaccine coverage, SARS-CoV-2 new variants tracking, and vaccine booster development.
Programmable chalcogenide-based all-optical deep neural networks
Authors: Teo Ting Yu , Ma Xiaoxuan , Pastor Ernest , Wang Hao , George Jonathan K. , Yang Joel K. W. , Wall Simon , Miscuglio Mario , Simpson Robert E. , Sorger Volker J. 
Published: May 2022

Abstract
We demonstrate a passive all-chalcogenide all-optical perceptron scheme. The network’s nonlinear activation function (NLAF) relies on the nonlinear response of Ge2Sb2Te5 to femtosecond laser pulses. We measured the sub-picosecond time-resolved optical constants of Ge2Sb2Te5 at a wavelength of 1500 nm and used them to design a high-speed Ge2Sb2Te5-tuned microring resonator all-optical NLAF. The NLAF had a sigmoidal response when subjected to different laser fluence excitation and had a dynamic range of −9.7 dB. The perceptron’s waveguide material was AlN because it allowed efficient heat dissipation during laser switching. A two-temperature analysis revealed that the operating speed of the NLAF is

≤
1

$\le 1$

ns. The percepton’s nonvolatile weights were set using low-loss Sb2S3-tuned Mach Zehnder interferometers (MZIs). A three-layer deep neural network model was used to test the feasibility of the network scheme and a maximum training accuracy of 94.5% was obtained. We conclude that combining Sb2S3-programmed MZI weights with the nonlinear response of Ge2Sb2Te5 to femtosecond pulses is sufficient to perform energy-efficient all-optical neural classifications at rates greater than 1 GHz.
The crystal structure of 1,2-bis(pyridinium-4-yl)ethane diperchlorate, C12H14N2·2ClO4 – a second polymorph
Authors: Qiu Qi-Ming , Song Jian-Biao , Yan Li , Dong Ai-Guo , Li Chuan-Tao , Zheng Zhi-Yuan 
Published: May 2022

Abstract
C12H14N2·2ClO4, monoclinic, P21/c (no. 14), a = 5.3170(4) Å, b = 12.8711(8) Å, c = 11.6788(7) Å, β = 100.888(2)°, V = 784.86(9) Å3, Z = 2, R

gt
(F) = 0.0434, wR

ref
(F
2) = 0.1211, T = 298 K.
Point Prevalence of the Biomechanical Dimension of Dysfunctional Breathing Patterns Among Competitive Athletes
Authors: Shimozawa Yuka , Kurihara Toshiyuki , Kusagawa Yuki , Hori Miyuki , Numasawa Shun , Sugiyama Takashi , Tanaka Takahiro , Suga Tadashi , Terada Ryoko S. , Isaka Tadao , Terada Masafumi 
Published: May 2022

Abstract
Shimozawa, Y, Kurihara, T, Kusagawa, Y, Hori, M, Numasawa, S, Sugiyama, T, Tanaka, T, Suga, T, Terada, RS, Isaka, T, and Terada, M. Point prevalence of the biomechanical dimension of dysfunctional breathing patterns among competitive athletes. J Strength Cond Res 37(2): 270–276, 2023—There is growing evidence of associations between altered biomechanical breathing patterns and numerous musculoskeletal and psychological conditions. The prevalence of dysfunctional and diaphragmatic breathing patterns is unknown among athletic populations. The purpose of this study was to examine the prevalence of dysfunctional and diaphragmatic breathing patterns among athletic populations with a clinical measure to assess the biomechanical dimension of breathing patterns. Using a cross-sectional design, 1,933 athletes across multiple sports and ages were screened from 2017 to 2020. Breathing patterns were assessed using the Hi-Lo test in the standing position. Scores of the Hi-Lo test were determined based on the presence or absence of abdominal excursion, anterior–posterior chest expansion, superior rib cage migration, and shoulder elevation. The Hi-Lo test scores were used to categorize observational breathing mechanics as dysfunctional and diaphragmatic breathing patterns. The prevalence of athletes with dysfunctional breathing patterns was 90.6% (1,751 of 1,933). Athletes with diaphragmatic breathing patterns accounted for 9.4% of all athletes in our sample (182 of 1,933). There were no differences in the proportion of breathing patterns between male and female athletes (p = 0.424). Breathing patterns observations were associated with sport-setting categories (p = 0.002). The highest percentages of dysfunctional breathers were in middle school student athletes (93.7%), followed by elementary school student athletes (91.2%), high school student athletes (90.6%), professional/semiprofessional athletes (87.5%), and collegiate athletes (84.8%). The current study observed that dysfunctional breathing patterns (90.6%) in the biomechanical dimension were more prevalent than diaphragmatic breathing pattern (9.4%) among competitive athletes. These results suggest that clinicians may need to consider screening breathing patterns and implementing intervention programs aimed to improve the efficiency of biomechanical dimensions of breathing patterns in athletic populations. This study may help raise awareness of impacts of dysfunctional breathing patterns on athletes' health and performance.
Sport Differences in Fat-Free Mass Index Among a Diverse Sample of NCAA Division III Collegiate Athletes
Authors: Brandner Caleb F. , Harty Patrick S. , Luedke Joel A. , Erickson Jacob L. , Jagim Andrew R. 
Published: May 2022

Abstract
Brandner, CF, Harty, PS, Luedke, JA, Erickson, JL, and Jagim, AR. Sport differences in fat-free mass index among a diverse sample of NCAA Division III collegiate athletes. J Strength Cond Res 36(8): 2212–2217, 2022—Fat-free mass index (FFMI) is becoming a popular metric to determine an athlete's potential for future fat-free mass accrual or to identify athletes who may be at risk for low fat-free mass (FFM). The aim of the current study was to examine sport-specific differences in FFMI among a cohort of collegiate athletes. NCAA Division III male (n = 98; age: 20.1 ± 1.6 years, height: 1.82 ± 0.06 m, body mass: 92.7 ± 17.5 kg, %BF: 15.6 ± 8.8%) and female (n = 92; age: 19.45 ± 1.1 years, height: 1.68 ± 0.06 m, body mass: 65.16 ± 11.04 kg, %BF: 22.71 ± 5.9%) athletes completed a body composition assessment using air displacement plethysmography. Fat-free mass index was calculated by dividing FFM by height squared. The mean ± SD FFMI was significantly higher (p < 0.05) for males (23.37 ± 2.41 kg·m−2) compared with females (17.54 ± 1.8 kg·m−2). There was a significant main effect for sport category. Post hoc analysis indicated that throwers had a higher (p < 0.001) FFMI (mean difference, 95% confidence interval) compared with sprinters and soccer athletes (4.17, 2.03–6.32 kg·m−2), endurance and weight-sensitive athletes (4.91, 2.67–7.14 kg·m−2), and court sport athletes (4.39, 1.97–6.81 kg·m−2), respectively, among female athletes. Post hoc analysis indicated that football players had a higher (p < 0.01) FFMI than distance runners (3.89, 2.15, 5.62) and wrestlers (2.23, 0.78, 3.68), among male athletes. These findings indicate that sex differences in FFMI exist, with differences identified between sports. These findings can guide strength and nutritional programming decisions by providing sport-specific normative data profiles.
New lathyrane diterpenoid hybrids have anti-inflammatory activity through the NF-κB signaling pathway and autophagy
Authors: Wang Wang , Xiong Liangliang , Wu Yanli , Zhou Yirong , Li Yutong , Zheng Mengzhu , Song Zhuorui , Sun Dejuan , Chen Lixia 
Published: May 2022

In our ongoing work on the identification of potent anti-inflammatory agents, we designed and synthesized three series of lathyrane diterpenoid hybrids in which the lathyrane diterpenoid skeleton was hybridized with other anti-inflammatory pharmacophores. Unexpectedly, lathyrane diterpenoid/3-hydroxyflavone hybrids showed more potent anti-inflammatory activity in RAW264.7 cells than did the corresponding parent compounds. Compound 8d1 exhibited potent anti-inflammatory activity with low cytotoxicity (IC50	= 1.55 ± 0.68 μM), and downregulated LPS-induced expression of iNOS and COX-2, as well as IκBα phosphorylation. This compound also inhibited the expression and nuclear translocation of NF-κB, and stimulated autophagy induction. Thus, 8d1’s anti-inflammatory mechanism is associated with inhibition of the NF-κB signaling pathway and increasing autophagy. This compound may serve as a promising anti-inflammatory agent.
Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
Authors: Ben-Zeev Zohar Steinberg , Peniakov Marina , Felszer Clari , Weiner Scott A , Lahad Avishay , Almashanu Shlomo , Tenenbaum Rakover Yardena 
Published: May 2022

Introduction
Maternal thyroid disease is considered as a risk factor for abnormal thyroid function at birth, as well as for long-term morbidity in offspring. The potential harmful effects on the neonate had led to the clinical practice of thyroid function assessment in infants born to mothers with thyroid disease during pregnancy. In this study, we evaluated the usefulness of routine thyroid function tests for every newborn of a mother with thyroid dysfunction.

Methods
Data were collected retrospectively from the medical files of mothers diagnosed with thyroid disease and their infants (496 mother–neonate pairs). All mothers with diagnosed thyroid disease who gave birth in the years 2016–2019 at our medical center were included.

Results
Hypothyroidism was the most common maternal diagnosis (91.4%), among which 48.7% had Hashimoto’s thyroiditis. Hyperthyroidism was diagnosed in 8.6% of the cohort – 71.6% of them with Graves’ disease. None of the newborns was diagnosed with congenital hypothyroidism in the screening program. Thyroid-stimulating hormone was >10 mIU/L in 14.6% and >20 mUI/L in 2.2%; all had free thyroxine within normal range. Serum thyroid function test identified four infants with thyroid disease; two had congenital hypothyroidism not related to maternal thyroid disease, one had transient familial congenital hypothyroidism and one had neonatal Graves’ disease.

Conclusions
Thyroid function testing for all newborns of mothers with thyroid dysfunction seems redundant. However, in cases of congenital hypothyroidism in siblings, thyroid function test, in addition to newborn thyroid screening, is recommended, and more careful follow-up is indicated. In maternal Graves’ disease, thyroid function test on days 2–3 of life is recommended.
Frecuencia de periodontitis apical en dientes con tratamiento endodóntico mediante tomografía computarizada volumétrica en una subpoblación de Colombia
Authors: Mesa Herrera Uriel , Blanco Fuentes Bibiana Yorley , Moreno Monsalve Jaime Omar 
Published: May 2022

Introducción: La interpretación radiográfica es un componente altamente subjetivo pero esencial para el diagnóstico de la periodontitis apical, las radiografías periapicales podrían subestimar su identificación cuando las lesiones son pequeñas, lo que podría generar falsos negativos. Por otra parte, la tomografía computarizada volumétrica tiene mayor sensibilidad para identificar y medir lesiones periapicales sutiles.
Objetivo: Determinar la frecuencia de periodontitis apical utilizando imágenes de tomografía computarizada de haz cónico en una subpoblación colombiana.
Métodos: Un total de 318 dientes y raíces con tratamientos endodónticos adecuados fueron incluidos en este estudio y evaluados mediante tomografía computarizada de haz cónico con voxel de 0,2 mm. La zona más amplia de radiolucidez apical en cada raíz dental fue medida y se le asigno un puntaje con base en el índice de radiolucidez endodóntica; la evaluación fue realizada por dos endodoncistas y un radiólogo. Frecuencias y porcentajes fueron utilizados para el análisis estadístico.
Resultados: El 60,37% de los dientes y raíces se calificaron sanas, mientras que el 39,63% de las raíces restantes presentaron periodontitis apical.
Conclusión: La frecuencia de PA en los dientes y raíces estudiadas y que mostraron tratamiento endodontico adecuado fue del 39,63% y el tamaño de las lesiones periapicales varío entre >0,5 y 2,5 mm.