bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings
Authors: Dziopa Katarzyna , Asselbergs Folkert W. , Gratton Jasmine , Chaturvedi Nishi , Schmidt Amand F. 
Published: January 2022

Abstract
Aims/hypothesis
We aimed to compare the performance of risk prediction scores for CVD (i.e., coronary heart disease and stroke), and a broader definition of CVD including atrial fibrillation and heart failure (CVD+), in individuals with type 2 diabetes.

Methods
Scores were identified through a literature review and were included irrespective of the type of predicted cardiovascular outcome or the inclusion of individuals with type 2 diabetes. Performance was assessed in a contemporary, representative sample of 168,871 UK-based individuals with type 2 diabetes (age ≥18 years without pre-existing CVD+). Missing observations were addressed using multiple imputation.

Results
We evaluated 22 scores: 13 derived in the general population and nine in individuals with type 2 diabetes. The Systemic Coronary Risk Evaluation (SCORE) CVD rule derived in the general population performed best for both CVD (C statistic 0.67 [95% CI 0.67, 0.67]) and CVD+ (C statistic 0.69 [95% CI 0.69, 0.70]). The C statistic of the remaining scores ranged from 0.62 to 0.67 for CVD, and from 0.64 to 0.69 for CVD+. Calibration slopes (1 indicates perfect calibration) ranged from 0.38 (95% CI 0.37, 0.39) to 0.74 (95% CI 0.72, 0.76) for CVD, and from 0.41 (95% CI 0.40, 0.42) to 0.88 (95% CI 0.86, 0.90) for CVD+. A simple recalibration process considerably improved the performance of the scores, with calibration slopes now ranging between 0.96 and 1.04 for CVD. Scores with more predictors did not outperform scores with fewer predictors: for CVD+, QRISK3 (19 variables) had a C statistic of 0.68 (95% CI 0.68, 0.69), compared with SCORE CVD (six variables) which had a C statistic of 0.69 (95% CI 0.69, 0.70). Scores specific to individuals with diabetes did not discriminate better than scores derived in the general population: the UK Prospective Diabetes Study (UKPDS) scores performed significantly worse than SCORE CVD (p value <0.001).

Conclusions/interpretation
CVD risk prediction scores could not accurately identify individuals with type 2 diabetes who experienced a CVD event in the 10 years of follow-up. All 22 evaluated models had a comparable and modest discriminative ability.

Graphical abstract
Obstetrical mode of delivery and behavioural outcomes in childhood and adolescence: findings from the Millennium Cohort Study
Authors: Maher Gillian M. , Khashan Ali S. , McCarthy Fergus P. 
Published: January 2022

Abstract
Purpose
To examine the association between mode of delivery (in particular caesarean section) and behavioural outcomes in offspring at six time-points between age 3 and 17 years.

Methods
Similar to previous work examining the association between mode of delivery and behavioural outcomes in offspring at age 7, we used maternal-reported data from the Millennium Cohort Study. Data on mode of delivery were collected when children were 9 months and categorised as spontaneous vaginal delivery, assisted vaginal delivery, induced vaginal delivery, emergency caesarean section, planned caesarean section and caesarean section after induction of labor. Data on behavioural outcomes were collected at ages 3, 5, 7, 11, 14 and 17 years using the Strengths and Difficulties Questionnaire (SDQ). Crude and adjusted logistic regression examined mode of delivery–behavioural difficulties relationship, using validated SDQ cut-off points (total SDQ ≥ 17, emotional ≥ 5, conduct ≥ 4, hyperactivity ≥ 7, peer problems ≥ 4 and prosocial behaviour ≤ 4). Multilevel models with linear splines examined the association between mode of delivery and repeated measures of SDQ.

Results
There were 18,213 singleton mother–child pairs included at baseline, 13,600 at age 3; 13,831 at age 5; 12,687 at age 7; 11,055 at age 11; 10,745 at age 14 and 8839 at age 17. Adjusted logistic regression suggested few associations between mode of delivery and behavioural outcomes at ages 3, 5, 11, 14 and 17 years using validated SDQ cut-off points. After correction for multiple testing, only the protective association between planned caesarean section-Conduct difficulties at age 5 years (OR 0.63, 95% CI 0.46, 0.85) and positive association between caesarean section after induction-Emotional difficulties at age 11 years (OR 1.57, 95% CI 1.19, 2.07) remained statistically significant. Multilevel modelling suggested mean SDQ scores were similar in each mode of delivery group at each time point.

Conclusions
Results of this study indicate that mode of delivery is unlikely to have a major impact on behavioural outcomes.
What distinguishes a model of systems engineering from other models of designing? An ontological, data-driven analysis
Authors: Kannengiesser Udo , Gero John S. 
Published: January 2022

AbstractThis paper investigates how the core technical processes of the INCOSE model of systems engineering differ from other models of designing used in the domains of mechanical engineering, software engineering and service design. The study is based on fine-grained datasets produced using mappings of the different models onto the function-behaviour-structure (FBS) ontology. By representing every model uniformly, the same statistical analyses can be carried out independently of the domain of the model. Results of correspondence analysis, cumulative occurrence analysis and Markov model analysis show that the INCOSE model differs from the other models in its increased emphasis on requirements and on behaviours derived from structure, in the uniqueness of its verification and validation phases, and in some patterns related to the temporal development and frequency distributions of FBS design issues.
Fast and reliable transient simulation and continuous optimization of large-scale gas networks
Authors: Domschke Pia , Kolb Oliver , Lang Jens 
Published: January 2022

AbstractWe are concerned with the simulation and optimization of large-scale gas pipeline systems in an error-controlled environment. The gas flow dynamics is locally approximated by sufficiently accurate physical models taken from a hierarchy of decreasing complexity and varying over time. Feasible work regions of compressor stations consisting of several turbo compressors are included by semiconvex approximations of aggregated characteristic fields. A discrete adjoint approach within a first-discretize-then-optimize strategy is proposed and a sequential quadratic programming with an active set strategy is applied to solve the nonlinear constrained optimization problems resulting from a validation of nominations. The method proposed here accelerates the computation of near-term forecasts of sudden changes in the gas management and allows for an economic control of intra-day gas flow schedules in large networks. Case studies for real gas pipeline systems show the remarkable performance of the new method.
How much Fear? Exploring the Role of Integral Emotions on Stated Preferences for Wildlife Conservation
Authors: Notaro Sandra , Grilli Gianluca 
Published: January 2022

AbstractScientific evidence suggests that emotions affect actual human decision-making, particularly in highly emotionally situations such as human-wildlife interactions. In this study we assess the role of fear on preferences for wildlife conservation, using a discrete choice experiment. The sample was split into two treatment groups and a control. In the treatment groups the emotion of fear towards wildlife was manipulated using two different pictures of a wolf, one fearful and one reassuring, which were presented to respondents during the experiment. Results were different for the two treatments. The assurance treatment lead to higher preferences and willingness to pay for the wolf, compared to the fear treatment and the control, for several population sizes. On the other hand, the impact of the fear treatment was lower than expected and only significant for large populations of wolves, in excess of 50 specimen. Overall, the study suggests that emotional choices may represent a source of concern for the assessment of stable preferences. The impact of emotional choices is likely to be greater in situations where a wildlife-related topic is highly emphasized, positively or negatively, by social networks, mass media, and opinion leaders. When stated preferences towards wildlife are affected by the emotional state of fear due to contextual external stimuli, welfare analysis does not reflect stable individual preferences and may lead to sub-optimal conservation policies. Therefore, while more research is recommended for a more accurate assessment, it is advised to control the decision context during surveys for potential emotional choices.
Prognostic impact of high-sensitive troponin on 30-day mortality in patients with acute heart failure and different classes of left ventricular ejection fraction
Authors: Ledwoch Jakob , Kraxenberger Jana , Krauth Anna , Schneider Alisa , Leidgschwendner Katharina , Schneider Vera , Müller Alexander , Laugwitz Karl-Ludwig , Kupatt Christian , Martens Eimo 
Published: January 2022

AbstractHigh-sensitive troponin T (hs-TnT) is increasingly used for prognostication in patients with acute heart failure (AHF). However, uncertainty exists whether hs-TnT shows comparable prognostic performance in patients with heart failure and different classes of left ventricular ejection fraction (LV-EF). The aim of the present study was to assess the prognostic value of hs-TnT for the prediction of 30-day mortality depending on the presence of HF with preserved ejection fraction (HFpEF), HF with mid-range LV-EF (HFmrEF) and HF with reduced LV-EF (HFrEF) in patients with acutely decompensated HF. Patients admitted to our institution due to AHF were retrospectively included. Clinical information was gathered from electronic and paper-based patient charts. Patients with myocardial infarction were excluded. A total of 847 patients were enrolled into the present study. A significant association was found between HF groups and hs-TnT (regression coefficient -0.018 for HFpEF vs. HFmrEF/HFrEF; p = 0.02). The area under the curve (AUC) of hs-TnT for the prediction of 30-mortality was significantly lower in patients with HFpEF (AUC 0.61) than those with HFmrEF (AUC 0.80; p = 0.01) and HFrEF (AUC 0.73; p = 0.04). Hs-TnT was not independently associated with 30-day outcome in the HFpEF group (OR 1.48 [95%-CI 0.89–2.46]; p = 0.13) in contrast to the HFmrEF group (OR 4.53 [95%-CI 1.85–11.1]; p < 0.001) and HFrEF group (OR 2.58 [95%-CI 1.57–4.23]; p < 0.001). Prognostic accuracy of hs-TnT in patients hospitalized for AHF regarding 30-day mortality is significantly lower in patients with HFpEF compared to those with HFmrEF and HFrEF.
Surgical treatment of the bony mallet thumb: a case series and literature review
Authors: Kastenberger Tobias , Kaiser Peter , Benedikt Stefan , Stock Kerstin , Eigl Magdalena , Schmidle Gernot , Arora Rohit 
Published: January 2022

Abstract
Introduction
The aim of this study was to provide a more precise statement on the outcome after surgical treatment of a bony mallet thumb and possibly give a treatment recommendation regarding the surgical fixation method.

Patients and methods
All patients (n = 16) who underwent a surgical treatment for an acute bony mallet thumb fracture between January 2006 and July 2019 were enrolled. The surgical method, complications, the range of motion, tip pinch, lateral key pinch, overall grip strength, visual analog score, Disability of the Arm, Shoulder and Hand Score, Mayo Wrist Score, Patient-Rated Wrist Evaluation Score, Buck-Gramcko Score and radiologic parameters were evaluated. Further, a comprehensive literature search on PubMed was conducted covering a period from 1956 to 2021 to include all possible matching articles on the treatment of the bony mallet thumb (n = 21 articles).

Results
Surgical treatment was very inhomogenous including indirect and direct K-wire fixation, screw fixation, plate fixation and anchor fixation methods. The IP joint range of motion and thumb strength ranged from 66 to 94% in comparison to the contralateral side. An open reduction led to worse functional scores compared to a closed reduction. Treatment methods in the literature were also very inhomogenous with a very low patient count, often even pooling data of bony mallet thumb fractures with bony mallet finger fractures. The risk for infection was higher in K-wire fixation methods than in open reduction and internal fixation methods.

Conclusion
The evidence for the best treatment of a bony mallet thumb fracture is low. On one hand the functional outcome can be inferior using an open reduction approach, but on the other hand, K-wire fixation methods with a closed reduction approach showed a higher risk for infection. Future multi-center research must be conducted to find the best treatment procedure for the best outcome of the patient.
Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties
Authors: Körner Jannis , Lampert Angelika 
Published: January 2022

AbstractSensory neurons are responsible for the generation and transmission of nociceptive signals from the periphery to the central nervous system. They encompass a broadly heterogeneous population of highly specialized neurons. The understanding of the molecular choreography of individual subpopulations is essential to understand physiological and pathological pain states. Recently, it became evident that species differences limit transferability of research findings between human and rodents in pain research. Thus, it is necessary to systematically compare and categorize the electrophysiological data gained from human and rodent dorsal root ganglia neurons (DRGs). In this systematic review, we condense the available electrophysiological data defining subidentities in human and rat DRGs. A systematic search on PUBMED yielded 30 studies on rat and 3 studies on human sensory neurons. Defined outcome parameters included current clamp, voltage clamp, cell morphology, pharmacological readouts, and immune reactivity parameters. We compare evidence gathered for outcome markers to define subgroups, offer electrophysiological parameters for the definition of neuronal subtypes, and give a framework for the transferability of electrophysiological findings between species. A semiquantitative analysis revealed that for rat DRGs, there is an overarching consensus between studies that C-fiber linked sensory neurons display a lower action potential threshold, higher input resistance, a larger action potential overshoot, and a longer afterhyperpolarization duration compared to other sensory neurons. They are also more likely to display an infliction point in the falling phase of the action potential. This systematic review points out the need of more electrophysiological studies on human sensory neurons.
Assessment of the perceived burden associated with Malignant Melanoma with Pictorial Representation of Illness and Self Measure (PRISM) and Melanoma Concerns Questionnaire (MCQ-28)
Authors: Borghi Alessandro , Flacco Maria Elena , Monti Alberto , Pacetti Lucrezia , Tabanelli Michela , Corazza Monica 
Published: January 2022

Abstract
Purpose
The impact of malignant melanoma (MM) on patients’ psychophysical well-being has been poorly addressed. We aimed to assess the perceived burden in patients with a diagnosis of MM, using two different tools, one generic and one specific for MM, such as Pictorial Representation of Illness and Self Measure (PRISM) and Melanoma Concerns Questionnaire (MCQ-28), respectively. The correlation between PRISM and MCQ-28 subscales and the relevance of disease and patient-related variables were also investigated.

Methods
This single-centre, cross-sectional study included all adult consecutive MM patients who attended our Dermatology Unit from December 2020 to June 2021. Demographics and disease-related data were recorded. PRISM and MCQ-28 were administered.

Results
One hundred and seventy-one patients were included (mean age: 59.5 ±14.9 years.; 48.0% males). Median time from MM diagnosis to inclusion was 36 months. Nearly 80% of the patients had in situ or stage I MM. Overall, 22.2% of the patients reported a PRISM score <100mm and similar percentages provided scores indicating impaired quality of life, as assessed with MCQ-28 subscales. A weak, albeit significant, correlation was found between PRISM scores and ACP, CON and SOC2 subscales. The most relevant association found was that between lower PRISM scores and higher-stage MM.

Conclusions
In the study population, mostly affected with superficial MM, their perception of the burden associated with MM did not appear either particularly dramatic or disabling. PRISM seems a reliable system for capturing and quantifying the domains correlated with the emotive dimension of MM, especially MM-related concerns and willingness to face life
A targeted bioinformatics approach identifies highly variable cell surface proteins that are unique to Glomeromycotina
Authors: Schultz Carolyn J. , Wu Yue , Baumann Ute 
Published: January 2022

AbstractDiversity in arbuscular mycorrhizal fungi (AMF) contributes to biodiversity and resilience in natural environments and healthy agricultural systems. Functional complementarity exists among species of AMF in symbiosis with their plant hosts, but the molecular basis of this is not known. We hypothesise this is in part due to the difficulties that current sequence assembly methodologies have assembling sequences for intrinsically disordered proteins (IDPs) due to their low sequence complexity. IDPs are potential candidates for functional complementarity because they often exist as extended (non-globular) proteins providing additional amino acids for molecular interactions. Rhizophagus irregularis arabinogalactan-protein-like proteins (AGLs) are small secreted IDPs with no known orthologues in AMF or other fungi. We developed a targeted bioinformatics approach to identify highly variable AGLs/IDPs in RNA-sequence datasets. The approach includes a modified multiple k-mer assembly approach (Oases) to identify candidate sequences, followed by targeted sequence capture and assembly (mirabait-mira). All AMF species analysed, including the ancestral family Paraglomeraceae, have small families of proteins rich in disorder promoting amino acids such as proline and glycine, or glycine and asparagine. Glycine- and asparagine-rich proteins also were found in Geosiphon pyriformis (an obligate symbiont of a cyanobacterium), from the same subphylum (Glomeromycotina) as AMF. The sequence diversity of AGLs likely translates to functional diversity, based on predicted physical properties of tandem repeats (elastic, amyloid, or interchangeable) and their broad pI ranges. We envisage that AGLs/IDPs could contribute to functional complementarity in AMF through processes such as self-recognition, retention of nutrients, soil stability, and water movement.
Assessment of consumer VR-headsets’ objective and subjective field of view (FoV) and its feasibility for visual field testing
Authors: Sauer Yannick , Sipatchin Alexandra , Wahl Siegfried , García García Miguel 
Published: January 2022

AbstractVirtual reality as a research environment has seen a boost in its popularity during the last decades. Not only the usage fields for this technology have broadened, but also a research niche has appeared as the hardware improved and became more affordable. Experiments in vision research are constructed upon the basis of accurately displaying stimuli with a specific position and size. For classical screen setups, viewing distance and pixel position on the screen define the perceived position for subjects in a relatively precise fashion. However, projection fidelity in HMDs strongly depends on eye and face physiological parameters. This study introduces an inexpensive method to measure the perceived field of view and its dependence upon the eye position and the interpupillary distance, using a super wide angle camera. Measurements of multiple consumer VR headsets show that manufacturers’ claims regarding field of view of their HMDs are mostly unrealistic. Additionally, we performed a “Goldmann” perimetry test in VR to obtain subjective results as a validation of the objective camera measurements. Based on this novel data, the applicability of these devices to test humans’ field of view was evaluated.
An explainable assistant for multiuser privacy
Authors: Mosca Francesca , Such Jose 
Published: January 2022

AbstractMultiuser Privacy (MP) concerns the protection of personal information in situations where such information is co-owned by multiple users. MP is particularly problematic in collaborative platforms such as online social networks (OSN). In fact, too often OSN users experience privacy violations due to conflicts generated by other users sharing content that involves them without their permission. Previous studies show that in most cases MP conflicts could be avoided, and are mainly due to the difficulty for the uploader to select appropriate sharing policies. For this reason, we present ELVIRA, the first fully explainable personal assistant that collaborates with other ELVIRA agents to identify the optimal sharing policy for a collectively owned content. An extensive evaluation of this agent through software simulations and two user studies suggests that ELVIRA, thanks to its properties of being role-agnostic, adaptive, explainable and both utility- and value-driven, would be more successful at supporting MP than other approaches presented in the literature in terms of (i) trade-off between generated utility and promotion of moral values, and (ii) users’ satisfaction of the explained recommended output.
Load-balancing for multi-skilled servers with Bernoulli routing
Authors: Miguelez Fernando , Doncel Josu , Prabhu Balakrishna J. 
Published: January 2022

AbstractWe study the optimal Bernoulli routing in a multiclass queueing system with a dedicated server for each class as well as a common (or multi-skilled) server that can serve jobs of all classes. Jobs of each class arrive according to a Poisson process. Each server has a holding cost per customer and use the processor sharing discipline for service. The objective is to minimize the weighted mean holding cost. First, we provide conditions under which classes send their traffic only to their dedicated server, only to the common server, or to both. A fixed point algorithm is given for the computation of the optimal solution. We then specialize to two classes and give explicit expressions for the optimal loads. Finally, we compare the cost of multi-skilled server with that of only dedicated or all common servers. The theoretical results are complemented by numerical examples that illustrate the various structural results as well as the convergence of the fixed point algorithm.