bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Qualitative Study Exploring the Experiences of Service Users With Complex Mental Health Needs
Authors: Saini Pooja , Sambrook Laura , Balmer Anna , Roks Hana , McIntyre Jason , Martin Antony , Tait Jackie , Ashley-Mudie Peter , Shetty Amrith , Nathan Rajan 
Published: June 2022

AimsLittle is known about the experiences of individuals presenting with complex mental health needs and the provision of care they receive for suicide and self-harm behaviours. There are limited data describing the support individuals receive from services and, where they do, how this support is provided. Research suggests that those presenting with a more complex clinical presentation may have a history of both suicide attempts and self-harm. The aim of the study is to explore the experiences of individuals with complex mental health needs in respect of their self-harm and suicidal behaviours, and experiences of support received from mental health care services.MethodsA semi-structured interview methodology was used to generate qualitative data. Representative participants with complex mental health needs were recruited from across Cheshire and Wirral Partnership NHS Foundation Trust, UK. Ten participants were interviewed for the study. Interviews were audio-recorded and transcribed verbatim. A transcript-based conceptual analysis was conducted to identify and explore emerging themes.ResultsThe following three themes emerged from the service user interviews: (i) Service users discussed suicide attempts following inappropriate discharge; Service users spoke about feeling unsupported and not listened to by care staff, particularly as inpatients; and (ii) Service users expressed a necessity for staff training to improve understanding of self-harm and suicide attempts, having experienced negative consequences of staff handling when they may have self-harmed.ConclusionThis study highlighted the following recommendations for future suicide prevention for mental health services treating service users with complex mental health needs: increasing staff awareness of suicide or self-harm related issues; improving training and risk assessment skills; providing appropriate support for service users following discharge from inpatient settings; improving liaison and collaboration between services to provide better service user outcomes; and increasing awareness in listening to service users’ distress about suicidal or self-harm thoughts for each individual's situational context.
Yorkshire and Humber Less Than Full Time Trainees: What Do They Need?
Authors: Shaw Laura , Davies Sara 
Published: June 2022

AimsDue to the demand for increased flexibility of working there is an ever-increasing number of trainees working Less Than Full Time (LTFT). The Royal College of Psychiatrists supports LTFT training and careers within the specialty. However, applying for and working LTFT can be a challenging and at times overwhelming process to navigate. This project's aims are to improve written information provided to trainees when commencing LTFT training. To assess interest for a LTFT training educational event and to plan this event based on trainees preferences for content and timing.MethodsQuestionnaires via SurveyMonkey were sent to higher trainees in all regions of the Yorkshire and Humber Deanery in October 2021 by the Medical Education Departments. A covering email invited those working or interested in LTFT to complete the questionnaire.Questions assessed the need for further written information on LTFT training in the region and interest in an educational event. Trainees already working LTFT were asked what they valued most out of support already in place.ResultsOf 40 trainees who responded, 100% stated when commencing LTFT training they would wish to receive more information. Respondents were asked which areas they would like included: practicalities (100% of respondents), LTFT mentor (85%), peer support (83%), weblinks to information (70%), recommended reading (53%). Those already working LTFT were asked what they had found helpful, the most common themes were mentoring, peer and supervisor support.85% of trainees surveyed confirmed they would be interested in attending a LTFT focused educational event. Based on trainee preferences the areas to be included were job planning (78%), choosing a job (81%), clinical lead views (78%), finances (86%), Out Of Programme opportunities (61%) and emotional aspects (61%). Further questions clarified preferences for a virtual Vs face-to-face meeting and timing to maximise attendance.ConclusionThere is a need for further information to be provided to trainees on LTFT training in the region. The content has been guided by trainees and will be incorporated into the Higher Trainee Handbook.For those training LTFT the most helpful aspect has been mentoring, peer and supervisor support. We have subsequently linked with the established mentoring scheme and those new to LTFT are matched with an established LTFT trainee. We recommend 3 monthly LTFT peer and Training Programme Director meetings continue.There is considerable interest in an educational event focused on LTFT working. This has been organised for May 2022 and the content guided by trainee's preferences.
Case Series Evaluating the Use of Combined Long Acting Injectable Antipsychotics in Three Patients Within Forensic Services
Authors: Moxon-Holt Megan , Todd Chris 
Published: June 2022

AimsAntipsychotic polypharmacy is a relatively common practice, despite a lack of robust evidence. In 2018, the National Clinical Audit of Psychosis evaluated the treatment of 8000 patients with a diagnosis of schizophrenia or schizoaffective disorder, and found 10% were receiving non-clozapine antipsychotic polypharmacy. This included 432 patients receiving one oral & one long acting injectable (LAI) antipsychotic and 2 patients receiving two LAI antipsychotics. An audit within our service, found that 24 of 88 (27%) inpatients were receiving non-clozapine antipsychotic polypharmacy. Of these, 3 were prescribed two LAI antipsychotics. A literature review found very limited evidence supporting the use of combined LAI antipsychotics, with publications relating to a total of 18 cases. Presented here is a case series, reviewing the use of LAI antipsychotic polypharmacy in three patients within Devon Partnership Trust.MethodsThe case series reports on three male inpatients, who are under the care of secure services within Devon Partnership Trust. All are currently prescribed two LAI antipsychotics. Two have a diagnosis of treatment resistant schizophrenia and one of schizoaffective disorder. All are complex, necessitating recurrent or lengthy admissions, and present with significant risk to others when unwell. In each case, there have been trials of multiple antipsychotics, but only one has had a previous trial of clozapine.ResultsPublished case reports highlight the positive effects of LAI polypharmacy, noting an improvement in mental state and lack of adverse effects. The cases presented here show significant variability, with one patient improving significantly, the second to a lesser extent, and the third remaining under high level observations.All cases are complex with decisions taken on a background of high risk, after multiple failed trials of medication.Although no specific adverse effects were reported, none of the patients regained sufficient insight to engage in treatment decisions and physical health monitoring. It is therefore difficult to quantify the adverse effect burden and weigh this against perceived efficacy.ConclusionCombined LAI antipsychotic medication is a possible treatment option in complex individual cases. Prescribing decisions are based on perceived clinical benefit, and the evidence base remains limited, with little understanding of long-term effects or consequences.Unlike high dose antipsychotics, there is no formalised guidance for prescribing combined LAI antipsychotics. Treatment targets and review processes were not always explicit. A more robust approach, would provide greater clarity around the practice and aid with future decision making.
Association of GLP1R Polymorphisms With the Incretin Response
Authors: Dorsey-Trevino Edgar G , Kaur Varinderpal , Mercader Josep M , Florez Jose C , Leong Aaron 
Published: June 2022

Abstract

Context
Polymorphisms in the gene encoding the glucagon-like peptide-1 receptor (GLP1R) are associated with type 2 diabetes but their effects on incretin levels remain unclear.

Objective
We evaluated the physiologic and hormonal effects of GLP1R genotypes before and after interventions that influence glucose physiology.

Design
Pharmacogenetic study conducted at 3 academic centers in Boston, Massachusetts.

Participants
A total of 868 antidiabetic drug-naïve participants with type 2 diabetes or at risk for developing diabetes.

Interventions
We analyzed 5 variants within GLP1R (rs761387, rs10305423, rs10305441, rs742762, and rs10305492) and recorded biochemical data during a 5-mg glipizide challenge and a 75-g oral glucose tolerance test (OGTT) following 4 doses of metformin 500 mg over 2 days.

Main Outcomes
We used an additive mixed-effects model to evaluate the association of these variants with glucose, insulin, and incretin levels over multiple timepoints during the OGTT.

Results
During the OGTT, the G-risk allele at rs761387 was associated with higher total GLP-1 (2.61 pmol/L; 95% CI, 1.0.72-4.50), active GLP-1 (2.61 pmol/L; 95% CI, 0.04-5.18), and a trend toward higher glucose (3.63; 95% CI, -0.16 to 7.42 mg/dL) per allele but was not associated with insulin. During the glipizide challenge, the G allele was associated with higher insulin levels per allele (2.01 IU/mL; 95% CI, 0.26-3.76). The other variants were not associated with any of the outcomes tested.

Conclusions
GLP1R variation is associated with differences in GLP-1 levels following an OGTT load despite no differences in insulin levels, highlighting altered incretin signaling as a potential mechanism by which GLP1R variation affects T2D risk.
SPS1 deficiency-triggered PGRP-LC and Toll expression controls innate immunity in Drosophila S2 cells
Authors: Yoo Tack-Jin , Sup Shim Myoung , Bang Jeyoung , Kim Jin-Hong , Jae Lee Byeong 
Published: June 2022

ABSTRACT
Selenophosphate synthetase 1 (SPS1) is an essential gene for the cell growth and embryogenesis in Drosophila melanogaster. We have previously reported that SPS1 deficiency stimulates the expression of genes responsible for the innate immune system, including antimicrobial peptides (AMPs), in Drosophila S2 cells. However, the underlying mechanism has not been elucidated. Here, we investigated the immune pathways that control the SPS1-deficiency-induced expression of AMPs in S2 cells. It was found that the activation of AMP expression is regulated by both immune deficiency (IMD) and the Toll pathway. Double knockdown of the upstream genes of each pathway with SPS1 showed that the peptidoglycan recognition protein-LC (PGRP-LC) and Toll genes are targeted by SPS1 for regulating these pathways. We also found that the IMD and Toll pathway regulate AMP expression by cross-talking. The levels of PGRP-LC and Toll mRNAs were upregulated upon Sps1 knockdown (6.4±0.36 and 3.2±0.45-fold, respectively, n=3). Overexpression of each protein also upregulated AMPs. Interestingly, PGRP-LC overexpression upregulated AMP more than Toll overexpression. These data strongly suggest that SPS1 controls the innate immune system of D. melanogaster through regulating PGRP-LC and Toll expression.
Minimal functional domains of the core polarity regulator Dlg
Authors: Khoury Mark J. , Bilder David 
Published: June 2022

ABSTRACT
The compartmentalized domains of polarized epithelial cells arise from mutually antagonistic actions between the apical Par complex and the basolateral Scrib module. In Drosophila, the Scrib module proteins Scribble (Scrib) and Discs-large (Dlg) are required to limit Lgl phosphorylation at the basolateral cortex, but how Scrib and Dlg could carry out such a ‘protection’ activity is not clear. We tested Protein Phosphatase 1α (PP1) as a potential mediator of this activity, but demonstrate that a significant component of Scrib and Dlg regulation of Lgl is PP1 independent, and found no evidence for a Scrib-Dlg-PP1 protein complex. However, the Dlg SH3 domain plays a role in Lgl protection and, in combination with the N-terminal region of the Dlg HOOK domain, in recruitment of Scrib to the membrane. We identify a ‘minimal Dlg’ comprised of the SH3 and HOOK domains that is both necessary and sufficient for Scrib localization and epithelial polarity function in vivo.
This article has an associated First Person interview with the first author of the paper.
Polycystic ovary syndrome and pregnancy - review
Authors: Grześk-Kaczyńska Magdalena , Ostrowska Magdalena , Pałac Dominika , Kaczyński Szymon 
Published: June 2022

Introduction and purpose
Polycystic Ovary Syndrome(PCOS) is one of the most common endocrinological disorders, and it affects 7-8 % of women globally. It is very heterogenous disease, which pathogenesis is complex and composed of many factors like genetics, hormonal changes, environmental factors and insulin resistance. PCOS has many symptoms, which appearance is dependent on comorbidities like obesity, diabetes mellitus, hypercholesterolemia. Due to complexity of the pathogenesis of PCOS it may have four phenotypes: A,B,C,D. The pregnancy pathologies connected to PCOS are mainly gestational diabetes mellitus, pregnancy induced hypertension. Pregnant women with PCOS have 3-4 times a higher risk of developing pregnancy induced hypertension (PIH) and preeclampsia and a three times higher risk of gestational diabetes mellitus (GDM). More than 64% of pregnancies in women with PCOS were terminated via caesarean section. Metformin, although still controversial may be a good option for the treatment of PCOS before and during pregnancy as a second-line therapy.
PCOS is a disease which affects the women in childbearing age and may have negative impact on its course. Pathologies connected to PCOS during pregnancy affect not only mothers, but foetus and according to new researches also children and adults from mothers with PCOS. It is very essential to extract women with PCOS to implement treatment and prevent its complications. Moreover, due to its common association with obesity patients should be under cardiologists care due to higher cardiovascular risk.
SOFRIMENTO INFANTIL CONTEMPORÂNEO: CONCEPÇÕES DE ESTUDANTES DE PSICOLOGIA
Authors: Reis Carlos Eduardo Soares , Carvalho Lana Veras 
Published: June 2022

Resumo: Diante das influências que o estilo de vida contemporâneo é capaz de imprimir na formação das subjetividades, questiona-se como as formas de sofrer das crianças podem ser reflexos dos vários pilares que sustentam a sociedade atual. Assim, o presente artigo objetiva descrever as concepções de estudantes de Psicologia de uma universidade pública do interior do Piauí sobre o sofrimento infantil contemporâneo. Para isso, foram realizadas entrevistas abertas, que passaram pela análise de conteúdo, com cinco alunos em fase final de graduação. Emergiram quatro categorias que demonstraram que as concepções dos graduandos consideram os valores capitalistas, a cultura do consumo, a patologização da vida e a “ausência dos pais” como pontos-chave para o sofrimento infantil. Diante disso, percebeu-se uma visão crítica dos estudantes ao analisar o problema de maneira mais abrangente e não se restringir apenas à interpretação do sofrimento como desequilíbrio químico. Além disso, os resultados dão margem para reflexão das influências do estilo de vida atual e sua necessidade de mudança, como também, alertam quanto à necessidade de uma prática profissional que não se conforme acriticamente com a força do mercado. Palavras-chave: Infância. Contemporaneidade. Sofrimento.Abstract: Faced with the influences that the contemporary lifestyle is capable of imprinting on the formation of subjectivities, it is questioned how children's ways of suffering can be reflections of the various pillars that sustain today's society. Thus, this article aims to describe the conceptions of psychology students from a public university in the interior of Piauí about contemporary child suffering. For this, open interviews were carried out, which underwent content analysis, with five students in the final stage of graduation. Four categories emerged that showed that the undergraduates' conceptions consider capitalist values, consumer culture, the pathologization of life and the “absence of parents” as key points for children's suffering. In view of this, a critical view of the students was perceived when analyzing the problem in a more comprehensive way and not being restricted only to the interpretation of suffering as a chemical imbalance. In addition, the conceptions give scope for reflection on the influences of the current lifestyle and its need for change, as well as warning about the need for a professional practice that does not conform uncritically with the strength of the market.Keywords: Childhood. Contemporaneity. Suffering.
REPRESENTAÇÕES DA OBESIDADE ENTRE ADOLESCENTES DO SEXO FEMININO
Authors: Leal Graziely Cordeiro , Ferret Jhainieiry Cordeiro Famelli , Branco Braulio Henrique Magnani , Silva Tânia Maria Gomes 
Published: June 2022

Resumo: A obesidade é um dos maiores problemas de saúde pública da atualidade, atingindo diferentes classes, gênero e gerações. A sociedade contemporânea é lipofóbica e os adolescentes, que se encontram num momento de construção de identidade, podem ser muito afetados quando seus corpos não são socialmente aprovados. Em vista disso, o presente artigo teve como objetivo discutir as representações da obesidade de adolescentes do sexo feminino que integram um programa de emagrecimento do Laboratório Interdisciplinar de Intervenção em Promoção da Saúde, da Universidade Cesumar, em Maringá/PR. Foram realizadas e gravadas entrevistas semiestruturadas com quatro delas. Utilizou-se a Teoria das Representações Sociais e a análise de conteúdo para interpretação dos dados. Evidenciou-se que as jovens sofrem pressões para o emagrecimento, numa confluência de discursos familiares e midiático. Observou-se, ainda, que, na escola, o bullying é uma prática comum a que se encontram expostas as pessoas que não têm o peso tido como ideal.Palavras chaves: Adolescência. Obesidade. Saúde. Representações sociais.Abstract: Obesity is one of the biggest public health problems nowadays, affecting different classes, genders and generations. Contemporary society is lipophobic and adolescents, who are in a moment of identity construction, can be very affected when their bodies are not socially approved. In view of this, the article seeks to discuss the representations of obesity in four female adolescents who are part of a weight-loss program, in the Interdisciplinary Laboratory of Health Promotion Intervention, at Cesumar University, in Maringa/PR. Semi-structured and recorded interviews were conducted. The Social Representations Theory and content analysis for data interpretation were used. It was evident that young women suffer under pressure to lose weight, in a confluence of both family and media discourses. It was also observed that at school, bullying is a common practice to which people who do not have the ideal weight are exposed. Keywords: Adolescence. Health promotion. Obesity. Social representation.
TRIPLE HELIX SPACES IN BRAZILIAN UNIVERSITIES DURING THE COVID-19 PANDEMIC
Authors: Almeida Mariza , Liboreiro Karla Rocha , Santos Eduardo Ferro , Alves Marco Antonio Baleeiro , Carvalho Sergio Paulino Medeiros , Borin Elaine Cavalcante Peixoto , Baeta Adelaide , Terra Branca 
Published: June 2022

Abstract: The advent of the 2019 Coronavirus disease – COVID-19 has placed the global spotlight on science, research, scientific knowledge and researchers, in the search for mitigating solutions at a time when some leaders in developed and developing countries are criticizing the role of science and its ability to overcome challenges. This article presents an analysis from the perspective of the triple helix model of significant initiatives introduced by Brazilian universities that enabled the identification of an effective response to the pandemic, highlighting the impact and adaptation to the adverse scenario, the rapid responses, the ability to establish forms of interaction that augmented the possibilities for intervention and collaboration with government, business and society in a time of crisis. The effectiveness of the triple helix (university-government-industry) movement, the spaces for consensus, knowledge and innovation during the COVID-19 pandemic, is presented in three case studies from the leading universities in the country.Keywords: Entrepreneurial university. Triple helix. Triple helix spaces. COVID-19. Brazil.Resumo: O advento da pandemia do COVID-19 colocou os holofotes globais em ciência, pesquisa, conhecimento científico e nos pesquisadores, na busca de soluções mitigadoras em um momento em que alguns líderes de países desenvolvidos e em desenvolvimento estão criticando o papel da ciência e sua capacidade de superar desafios. Este artigo apresenta uma análise, na perspectiva do modelo de tríplice hélice de iniciativas significativas introduzidas pelas universidades brasileiras que possibilitaram a identificação de uma resposta efetiva à pandemia, destacando o impacto e a adaptação ao cenário adverso, as respostas rápidas, a capacidade de estabelecer formas de interação que aumentassem as possibilidades de intervenção e colaboração com o governo, negócios e sociedade em um momento de crise. A eficácia do movimento tríplice hélice (universidade-governo-indústria), os espaços de consenso, conhecimento e inovação durante a pandemia COVID-19, é apresentada em três estudos de caso das principais universidades do país. Palavras-chave: Universidade empreendedora. Hélice tríplice. Espaços da hélice tríplice. COVID-19. Brazil.
Outrage sur les plages. La constitution du port du burkini en problème public sous l’angle de la panique morale
Authors: Leconte Cécile 
Published: June 2022

L’article étudie la controverse qui, à l’été 2016, entoure l’interdiction, de facto, du port du burkini sur les plages par une trentaine de communes françaises. En mobilisant le modèle de Cohen pour analyser les cadrages dont font l’objet les porteuses de burkini, cette étude entend montrer ce qui nous semble distinguer la panique morale d’autres configurations du débat public que sont la controverse, l’affaire ou le scandale : à savoir, le processus de construction du « folk devil » comme archétype social menaçant les conditions mêmes de possibilité du vivre ensemble, qui nous semble constituer l’apport central de StanleyCohen à la sociologie des problèmes publics. Si, dans le cas du burkini, ce processus est largement attribuable à une coalition d’acteurs rassemblant intellectuels médiatiques et professionnels de la politique, l’on ne saurait en faire une lecture purement stratégiste. D’une part, le cadrage des adeptes du burkini comme « folk devil » mobilise un certain nombre de représentations relatives au gouvernement des musulman·e·s dans l’espace public propres au contexte français. D’autre part, le cas du burkini permet de remettre au centre de l’analyse une dimension parfois négligée de la panique morale, à savoir sa topographie. Davantage qu’un élément de contexte, la plage apparaît ici comme un espace-enjeu, contesté, dont la territorialisation et la patrimonialisation participent pleinement du processus de constitution du « folk devil ».