bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mehar approach to solve neutrosophic linear programming problems using possibilistic mean
Authors: Bhatia Tanveen Kaur , Kumar Amit , Sharma M K , Appadoo S S 
Published: April 2022

Abstract
Khatter (Soft Computing 24 (2020) 16847–16867) pointed out that although several approaches are proposed in the literature to solve single-valued neutrosophic linear programming problems (SVNLPPS) (linear programming problems in which all the parameters except decision variables are either represented by single-valued triangular neutrosophic numbers (SVTNNS) or single-valued trapezoidal neutrosophic numbers (SVTrNNS)). However, all the methods for comparing single-valued neutrosophic numbers (SVNNS), used in existing approaches, are independent from the attitude of the decision maker towards the risk. To fill this gap, Khatter (2020), firstly, proposed a method for comparing two SVNNS by considering the attitude of the decision maker towards the risk. Then, using the proposed comparing method, Khatter (2020) proposed an approach to solve SVNLPPS. In this paper, it is pointed out that a mathematical incorrect result is considered in Khatter’s approach. Hence, it is inappropriate to use Khatter’s approach. Also, it is pointed out that some mathematical incorrect results are considered in other existing approaches for solving SVNLPPS. Hence, it is inappropriate to use other existing approaches for solving SVNLPPS. Furthermore, to resolve the inappropriateness of Khatter’s approach and other existing approaches, a new approach (named as Mehar approach) is proposed to solve SVNLPPS. Finally, correct optimal solution of some existing SVNLPPS is obtained by the proposed Mehar approach.
Adaptive posture-balance cardiac rehabilitation exercise significantly improved physical tolerance in patients with cardiovascular diseases
Authors: Li Ting , Ma Mei , Zhang bowen , Yan Xinxin , Qin Deyu , Pu Chaodong , Zhao Jingxiang , Zhang Qian , Lowis Heinz , Ji Xiang 
Published: April 2022

Abstract
Background: This study aimed to assess the effect of a self-created therapy with adaptive posture-balance cardiac rehabilitation exercise (APBCRE) on physical tolerance in patients with cardiovascular diseases (CVDs), in terms of the measurements from the exercise cardiopulmonary function measurement system.Methods: The CVDs patients were selected into this study, in which every subject was guided to take an APBCRE evenly twelve times per month. At baseline and after one-month APBCRE, participants underwent cardiopulmonary exercise testing (CPET) measurements, resting metabolic rate (RMR), and filled in questionnaires about quality of life (QoL). The results of CPET and QoL at multiple time points were statistically analyzed to evaluate the clinical therapeutic effects of one-month APBCRE. The factor of age was addressed in data analysis as well.Results: 93 samples (80.65% male, 53.03±12.02 years) were included into the analysis. After one-month APBCRE, oxygen update (VO2, 11.16±2.91 to 12.85±3.17 mL/min/kg, p<0.01), ventilation (VE, 28.87±7.26 to 32.42±8.50 mL/min/kg, p<0.01), respiratory exchange ratio (RER, 0.93±0.06 to 0.95±0.05, p<0.01) in anaerobic threshold and oxygen uptake efficiency slope (OUES) (1426.75±346.30 to 1547.19±403.49, P<0.01) of the participants improved significantly. Moreover, compared with the >55-year group, the ≤55-year group acted much higher increment (VO2 at anaerobic threshold, 23% vs. 16%; OUES, 13% vs. 6%). The quality of life score (SF-12) was also improved with rehabilitation (47.78±16.74 to 59.27±17.77, p<0.001). Conclusions: This study proved that APBCRE was a potentially available exercise rehabilitation modality for patients with cardiovascular diseases, which significantly improved physical tolerance and quality of life, more effectively for ≤55-year patients.
Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe
Authors: SIMON-LORIERE Etienne , Montagutelli Xavier , Lemoine Frederic , Donati Flora , Touret Franck , Bourret Jerome , Prot Matthieu , Munier Sandie , Attia Mikael , Conquet Laurine , Nguyen Scott , amara faustine , Maisa Anna , Fournier Lucie , Brisbarre Angela , dehan oceane , Levillayer Laurine , Gunalan Vithiagaran ,   The Danish COVID-19 Genome Consortium (DCGC), Fonager Jannik , Rasmussen Morten , Kemeny Stephan , Zrhidri Abdelali , Duret Thomas , Behillil Sylvie , Enouf Vincent , Rodriguez Christophe , Fourati Slim , Pawlotsky Jean-Michel , Capron Nicolas , Leroy Hugues , Alessandri-Gradt Elodie , Juszczak Florian , Gheysen Laetitia , Brodard Véronique , Moret Hélène , Bos Martine , Welkers Matthijs , Scholz Claus , Paraskevopoulou Sofia , Josset Laurence , Cervi Claire , Couzon Brigitte , Marque-Juillet Stéphanie , Delaune Deborah , Khiari Slim El , Fumey Julien , Hallouin-Bernard Marie-Charlotte , Rey Félix , Yazdanpanah Yazdan , Coignard Bruno , de Lamballerie Xavier , Werf Sylvie van der , Paquin Axelle 
Published: April 2022

Abstract

Recombination is a crucial process in the evolution of many organisms. Although the evolutionary reasons behind its occurrence in RNA viruses are debated, this phenomenon has been associated with major epidemiological events such as virus host range expansion, antigenic shift or variation in virulence 1,2, and this process occurs frequently in positive strand RNA viruses such as coronaviruses. The SARS-CoV-2 pandemic has been associated with the repeated emergence of variants of concern presenting increased transmissibility, severity or immune escape 3. The recent extensive circulation of Delta worldwide and its subsequent replacement by viruses of the Omicron lineage 4 (BA.1 then BA.2), have created conditions for genetic exchanges between viruses with both genetic diversity and phenotypic specificities 5-7. Here we report the identification and in vitro and in vivo characterization of a Delta-Omicron recombinant in Europe. This recombinant exhibits immune escape properties similar to Omicron, while its behavior in mice expressing the human ACE2 receptor is more similar to Delta. This recombinant provides a unique and natural opportunity to better understand the genotype to phenotype links in SARS-CoV-2.
C/EBP-β LAP regulates chemo-immuno-resistance in hypoxic non-small cell lung cancer
Authors: Salaroglio Iris C. , Belisario Dimas Carolina , Akman Muhlis , Vecchia Sofia La , Godel Martina , Anobile Dario Pasquale , Ortone Giacomo , Digiovanni Sabrina , Fontana Simona , Costamagna Costanzo , Kopecka Joanna , Riganti Chiara 
Published: April 2022

Abstract
Background: Solid tumors subjected to intermittent hypoxia are characterized by resistance to chemotherapy and immune-killing by effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular circuitries determining this double resistance are not known. Methods: We analyzed a panel of 28 human non-small cell lung cancer (NSCLC) lines, using an in vitro system simulating continuous and intermittent hypoxia to. Chemosensitivity to cisplatin and docetaxel was evaluated by chemiluminescence, ex vivo Vγ9Vδ2 T-lymphocyte expansion and immune-killing by flow cytometry. Targeted transcriptomic identified efflux transporters and nuclear factors involved in chemo-immuno-resistance. The molecular mechanism linking Hypoxia-inducible factor-1α (HIF-1α), CCAAT/Enhancer Binding Protein-β (C/EBP-β) isoforms LAP and LIP, and ABCB1, ABCC1, ABCA1 transporters were evaluated by immunoblotting, RT-PCR, RNA-IP, ChIP. Oxidative phosphorylation, mitochondrial ATP, ROS and depolarization were measured spectrofluorimetrically. The role of ROS/HIF-1α/LAP axis was validated in HIF-1α/LAP knocked-out/overexpressing cells, and in humanized (Hu-CD34+NSG) mice bearing LAP-overexpressing tumors. The clinical meaning of LAP was assessed in 60 NSCLC patients prospectively enrolled, treated with chemotherapy.Results: By up-regulating ABCB1 and ABCC1, and down-regulating ABCA1, intermittent hypoxia induced a stronger chemo-immuno-resistance than continuous hypoxia in NSCLC cells. Intermittent hypoxia impaired the electron transport chain, increasing mitochondrial ROS that favor the stabilization of C/EBP-β mRNA mediated by HIF-1α. HIF-1α/C/EBP-β mRNA binding increases the production of LAP isoform that transcriptionally induces ABCB1 and ABCC1, promoting the efflux of cisplatin and docetaxel. LAP also decreases ABCA1, limiting the efflux of isopentenyl pyrophosphate, i.e. the endogenous activator of Vγ9Vδ2 T-cells, and reducing the immune-killing. In NSCLC patients subjected to cisplatin-based chemotherapy, C/EBP-β LAP was abundant in hypoxic tumors and was associated with lower response to treatment and survival. Accordingly, in Hu-CD34+NSG mice, LAP-overexpressing tumors were more chemo-immuno-resistant than parental tumors. Interestingly, the ROS scavenger mitoquinol re-induced chemo-immuno-sensitization, by disrupting the ROS/HIF-1α/LAP cascade. Conclusion: The impairment of mitochondrial metabolism induced by intermittent hypoxia increases the ROS-dependent stabilization of HIF-1α/LAP complex in NSCLC, producing chemo-immuno-resistance. Clinically used mitochondrial ROS scavengers may counteract such double resistance. Moreover, we suggest C/EBP-β LAP as a new predictive and prognostic factor in NSCLC patients.
ATP-Binding Cassette Cholesterol Transporter–1 (ABC1) G1051A, and G2706A Gene Polymorphism in patients with primary hyperlipidemi
Authors: Karadeniz Muammer , Ozgen Ahmet Gokhan , Vardarlı Asli Tetik , Cetintas Vildan Bozok , Eroglu Zuhal , Erdogan Mehmet 
Published: April 2022

Abstract
Objective: we aimed to investigate the effects of ABCA1 G2706A and G1051A gene polymorphisms on glycemic levels, and inflammatory markers as hs-CRP, and fibrinogen in patients with primary hyperlipidemia.Material, and Method:Sixty male and 78 female patients participated in the study. DNAs of white blood cells were isolated, and ABCA1 G2706A, and G1051A gene polymorphisms were analyzed using PCR. Results: Among patients included in the study, systolic blood pressures of the patients carrying AA genotype in ABCA-1 2706 gene polymorphism were lower relative to those having AG, and GG genotypes. (p=0.027). Statistical analysis performed between ABCA1 G1051A (R219K) gene polymorphism, and HDL-cholesterol levels revealed that HDL-cholesterol level was statistically significantly higher in patients with GG genotype when compared with those having AA, and AG genotypes (p=0.047). The presence of metabolic syndrome did not differ statistically significantly among patients carrying ABCA1 G2706A polymorphism. [GA genotype vs GG genotype (p=0.321, OR: 0.364), AA genotype vs GG genotype (p=0.438, OR: 0.534)]. Incidence of metabolic syndrome in ABCA1 gene G1051A polymorphism in patients carrying GG genotype was significantly more frequently detected in those having GA (p=0.001, OR: 5.816) or AA (p=0.039, OR: 3.619) genotype. On the other hand, the individuals with AA genotype had lower systolic blood pressures.Conclusion: ABCA1 gene polymorphism has been seen to be correlated with hypertension, and metabolic syndrome apart from HDL-cholesterol metabolism
BGM, a newly synthesized boron compound, induces apoptosis and reduces oxidative stress by inhibiting lipogenesis in 3T3-L1 adipocytes via PPARγ and CTRP3
Authors: KOLDEMİR-GÜNDÜZ Meliha 
Published: April 2022

Abstract
Obesity is a chronic disease associated with increased morbidity and mortality. The rapidly increasing prevalence of obesity makes it a global health problem, while treatment options remain limited. Given the potential of boron in the treatment of obesity, the aim of this study is to investigate the anti-adipogenic activity of the newly synthesized boron glycine monoester compound (BGM) using 3T3-L1 adipocytes by analysing lipid accumulation, CTRP3 and PPARy gene expression, oxidative stress and apoptotic effects. 3T3-L1 fibroblast cells (ATCC® CL − 173) were transformed into adipocyte cells in vitro. Fat accumulation in the 3T3-L1 adipocyte cells was detected by oil red O staining. Gene expression levels were determined with qPCR. Biochemical analyzes were performed using spectrophotometric method (CAT, ALP and ACP) and ELISA kit (TAS, TOS, NADP-IDH). Apoptosis studies were performed on the Muse Cell Analyzer using the Muse Annexin V & Dead Cell Assay Kit. When BGM-treated cells were compared to control adipocyte cells, lipid accumulation decreased in a dose-dependent manner. BGM-treated adipocyte cells had higher CTRP3 expression levels and lower PPAR-γ gene expression levels compared to control adipocyte cells (p < 0.001). While BGM application increased the TAS level, it showed an antioxidant effect by regulating the activity of oxidative metabolism enzymes (p < 0.001). BGM application increased total apoptosis by 1.5 fold. These results show that BGM is a potential therapeutic agent for obesity by regulating the expression of genes related to adipogenesis and lipogenesis in adipocyte cells and by affecting the activity of enzymes of oxidative metabolism and apoptosis.
Pneumonia Due to Mixed Infection From Atopobium Vaginae and Gardnerella Vaginalis Detected by Metagenomic Next-Generation Sequencing: A Case Report
Authors: Zhang Qian , Wenying Xia , Suming Zhou , Yi Han 
Published: April 2022

Abstract
Background
Atopobium vaginae and Gardnerella vaginalis are commensal vaginal bacteria. They are common pathogens of bacterial vaginosis and rarely cause pneumonia.
Methods
We report a case of a 27-year-old female with severe pneumonia, diabetic ketoacidosis, and hyperthyroidism. Notably, a mixed infection from A. vaginae and G. vaginalis was confirmed by metagenomic next-generation sequencing (mNGS).
Results
The mNGS of bronchoalveolar lavage fluid showed a total of 10,548 reads of A. vaginae, with a genome coverage rate of 26.63% and 5,237 reads of G. vaginalis, with a genome coverage rate of 34.76%. The patient recovered after ceftriaxone and ornidazole treatments.
Conclusion
This case demonstrated the advantage of mNGS in detecting unusual pathogens in pneumonia. Our diagnostic and treatment approaches could provide a reference for the future management of pneumonia due to a mixed infection from A. vaginae and G. vaginalis.
Environmental extremes at high altitudes drive clutch size patterns in a wide-ranging lizard
Authors: Deme Gideon Gywa , Wu Nicholas C. , Sun Baojun , Hao Xin 
Published: April 2022

Abstract
Latitudinal patterns in reproductive output such as clutch size are linked to resource abundance and seasonal climate variation across taxa. Understanding if these patterns hold across local altitudinal gradients and within species can provide insight into key drivers of life-history evolution across scales. In this study, we examined geographical variations in clutch size and climate conditions in a wide-ranging lizard. We collected clutch data from ten populations of E. argus of varying elevation in China from both field observation and from the literature. A total of 369 clutches were obtained and generalized linear mixed-effects models were used to test the relationship between clutch size with body mass, habitat type, elevation, and climate conditions. Body mass strongly correlated with clutch size across all populations. Females from populations at high altitudes with low mean annual temperature and variability, and drier conditions had smaller clutches, while females at lower altitudes with higher mean temperatures and rainfall had larger clutch sizes. Poor climate conditions at high altitudes suggest fewer resources for females to invest in larger clutch sizes, likely due to reduced foraging and activity times, and growth under unfavourable conditions. These constraints match macroecological patterns of clutch size diversity in egg-laying taxa, suggesting local climate constraints can translate across scales to explain the diversity of reproductive output.
Families of exact solutions of a Generalized (2+1)-dimensional Boussinesq type equation
Authors: Li Mao-Hua , Chen Cai-Feng 
Published: April 2022

Abstract
In this paper, we study a Generalized (2+1)-dimensional Boussinesq type equation. Through the Hirota bilinear method, we give the $N$-order bright soliton solutions and dark soliton solutions. For the one-soliton solution, the bright soliton solution and the dark soliton solution have the same limit line and different extreme values. Based on soliton solutions, we give higher-order bright and dark breather solutions and mixed solutions. The dynamic behavior is characterized by images. Through the long-wave limit method, we obtain the bright and dark lump solution. It is worth noting that they have the same extreme points and different extreme values. In addition, we also get two semi-rational solutions as lump-soliton and lump-breather. It is found that the collision between lump and soliton is elastic.
Effect of Municipal Solid Waste compost Treatment on Physico-Chemical Properties of Garden Soil
Authors: Lalremruati Mary , Devi AngomSarjubala , Singh Anil Pratap 
Published: April 2022

Abstract
In the present study amendment of three types of compost made from lemon peels (LP), vegetable waste (VW) and cook food waste (CF) in garden soil was carried out. It was observed that pH in all the treatments increased from control with a maximum in LP with 22% and minimum in CF with 10% at 270 days.The soil temperature was higher than control with a maximum increase of 52% in CF and minimum of 20% in VW at 90 days. A maximum increase of OC was observed in CF compost treated soilwith 106% followed by LP with 64% and 24% in VW at 90 days.TN increased from control upto 90 days with 484, 100 and 46% rise in CF, VW and LP respectively. AP and AK also showed a very high increase rate with maximum of 551% in CF and 703% in LP respectively.
Clinical Features of Microbial Reactivation in Early Onset of Severe Pneumonia by Metagenomic Next-Generation Sequencing in Intensive Care Units, a Multicenter, Retrospective Study
Authors: Huang Lingtong , Pang Lisha , Sheng Peng , Wang Yanqiu , Yang Fan , Yu Huili , Zhang Ning , cai Hongliu , Tang Lingling , Fang Xueling 
Published: April 2022

Abstract
Purpose: This study aims to assess the clinical features of microorganism reactivation in the early onset of severe pneumonia in ICU patients.Methods: A total of 97 patients’ clinical data was collected retrospectively from intensive care units of five teaching hospitals in China from June 2018 to July 2021 followed by metagenomic next-generation sequencing (mNGS) of the bronchoalveolar lavage fluid (BALF) at the onset of severe pneumonia.Results: A total of 43 pathogenic microorganisms were detected in 97 patients with severe pneumonia by mNGS, where CMV (21.6%), HSV-1 (18.6%), and Pneumocystis (14.4%) were the most common reactivated microorganisms in the lungs of patients with severe pneumonia. In the present study, reactivation was considered when mNGS detected CMV, HSV-1, or Pneumocystisc DNA. A total of 11 patients (11.3%) had two or more reactivated microorganisms, and the overall rate of microbial reactivation was 40.2%. After adjusting for the risk of confounding and competition, one or more reactivations of CMV, HSV-1, and Pneumocystis resulted in an overall increase of 2.381 folds of mortality (95% CI: 1.198-4.733). Conclusion: This study showed that CMV, HSV-1, and Pneumocystis were the most common reactivated microorganisms in the lungs of patients in the ICU at the onset of severe pneumonia. Reactivation of two or three microorganisms is common and is associated with an increased risk of mortality.
Evaluation of sleep support workshop- what parents think
Authors: Banerjee Tapomay , Fernando Callum , Yemula Chinnaiah , Holmes Sarah , Taylor Elizabeth , Albone Sharon , Josan Gurdip 
Published: April 2022

Abstract
Poor sleep can lead to neurodevelopmental, academic and behavioural consequences in children and young people. Sleep disorders, although common in children but appropriate diagnosis and support is often not available locally. We conducted a single centre survey among parents who attended sleep support workshop offered by Bedford community paediatric service. 28 parents responded (out of 70). 12 had already seen paediatrician for assessment of neurodevelopmental disorders, 11 waiting and 5 had isolated sleep issues. Difficulty in falling asleep (23), difficulty in maintaining sleep (11) and early morning waking (9) were main complains. The survey showed subjective improvement in knowledge about sleep problems in parents and 16/28 parents felt some improvement in their child’s sleep. This small scale, single centre observation suggests that sleep support training can improve parental understanding of sleep problems and may improve sleep problems in children.
Transitional Probabilities for Plastic Waste Management and Implication on Sustainability
Authors: Addor John Awuah , Wiah Eric Neebo , Alao Felix Ilesanmi 
Published: April 2022

Abstract
The global economy seems to be sinking in the ocean of plastic wastes. Plastic circular economy has been prescribed the key panacea with recycling as its key strategy. The issue of sustainable plastic circular economy has so far been the challenge amid the production of virgin plastics. The aim of this study is to assess the sustainability of plastic circular economy with complete dependence on plastic wastes. Sustainability assessment criterion was based on plastic waste generation and recycling transitional probabilities. A closed system is assumed to ensure that no new virgin plastic is produced. Data was obtained from various publications of the Plastic Europe; and other research publications on plastic waste management. Sustainability was then assessed under four scenarios; joint force of plastic waste incineration and discarding, plastic waste discarding without incineration, plastic waste incineration without discarding; and complete riddance of plastic waste incineration and discarding. It was revealed that the already cumulated volume of global annual plastic waste generated can sustain plastic circular economy in a closed system only if plastic waste incineration and discarding are completely prohibited. The study is an indispensable tool for policy formulation in the area of waste management.
Two Cu(I\II) Coordination Polymers for Photocatalytic Degradation of Organic Dyes and Efficient Detection of Fe3+ ions
Authors: Xu Chenyan , Chen Wenqian , Wang Jiajun , Wu Qiuyu , Wu Pengyan , Tang Liang 
Published: April 2022

Abstract
Two new copper-based coordination polymers (CPs), {[CuI(H2PO4)(dpe)]5(dpe)0.5(H2O)7}n (Cu-dpe(I)) and {[CuII(HPO4)(dpe)(H2O)](H2O)3}n (Cu-dpe(II)) (dpe = 1,2-di(4-pyridyl)ethylene), had been successfully constructed by hydrothermal method and ball milling method respectively. The crystal structures of two coordination polymers were determined by single crystal X-ray diffraction. The synthetic temperature caused their structure differences. The differences of structure and properties between these two coordination polymers were discussed. In this work, they both exhibit excellent photocatalytic activity toward the degradation of methylene blue (MB) under visible light. Among them, Cu-dpe(I) and Cu-dpe(II) could degrade MB more than 88.1% in 120 minutes under visible light. Some active free radicals such as ·OH, ·O2-, e- played an important role in degradation of MB. In addition, luminescent experiment revealed Cu-dpe(I) exhibits a relatively high sensitive and selective detection of Fe3+ ions in water solution. Experimental results show that the fluorescence quenching was caused by competitive absorption of excitation wavelength energy between Fe3+ and Cu-dpe(I).