bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of critical genes associated with radiotherapy resistance in cervical cancer by bioinformatics
Authors: Zhang Zhenhua , Xiang Kechao , Tan Longjing , Du Xiuju , He Huailin , Li Dan , Li Li , Wen Qinglian 
Published: July 2022

BackgroundCervical cancer (CC) is one of the common malignant tumors in women, Currently, 30% of patients with intermediate to advanced squamous cervical cancer are still uncontrolled or recurrent after standard radical simultaneous radiotherapy; therefore, the search for critical genes affecting the sensitivity of radiotherapy may lead to new strategies for treatment.MethodsFirstly, differentially expressed genes (DEGs) between radiotherapy-sensitivity and radiotherapy-resistance were identified by GEO2R from the gene expression omnibus (GEO) website, and prognosis-related genes for cervical cancer were obtained from the HPA database. Subsequently, the DAVID database analyzed gene ontology (GO). Meanwhile, the protein-protein interaction network was constructed by STRING; By online analysis of DEGs, prognostic genes, and CCDB data that are associated with cervical cancer formation through the OncoLnc database, we aim to search for the key DEGs associated with CC, Finally, the key gene(s) was further validated by immunohistochemistry.Result298 differentially expressed genes, 712 genes associated with prognosis, and 509 genes related to cervical cancer formation were found. The results of gene function analysis showed that DEGs were mainly significant in functional pathways such as variable shear and energy metabolism. By further verification, two genes, ASPH and NKAPP1 were identified through validation as genes that affect both sensitivities to radiotherapy and survival finally. Then, immunohistochemical results showed that the ASPH gene was highly expressed in the radiotherapy-resistant group and had lower Overall survival (OS) and Progression-free survival (PFS).ConclusionThis study aims to better understand the characteristics of cervical cancer radiation therapy resistance-related genes through bioinformatics and provide further research ideas for finding new mechanisms and potential therapeutic targets related to cervical cancer radiation therapy.
Communicative deficits associated with maladaptive behavior in individuals with deafness and special needs
Authors: Fellinger Johannes , Dall Magdalena , Weber Christoph , Holzinger Daniel 
Published: July 2022

BackgroundAt least one in three individuals who are prelingually deaf has special needs, most commonly due to intellectual disabilities. The scant literature on challenging behavior in this population, however, suggests high rates of prevalence and an important need to better understand the contributing factors.AimWe sought to analyze the prevalence of maladaptive behavior and its association with intellectual functioning, adaptive skills, language skills, and social communication in a population of adults with deafness and special needs.MethodsParticipants were 61 individuals from three therapeutic living communities established for people with deafness and special needs. The participants had a mean age of 54.7 years, 64% were male. Intellectual functioning was measured with two versions of the Snijders–Oomen Non-verbal Intelligence Scale. The Vineland-II Scales were used to assess adaptive and maladaptive behavior. Language skills were measured with instruments specifically adapted for this population, including the Reynell Developmental Language Comprehension Scale, the comprehension scale of the Child Development Inventory, and the Profile of Multiple Language Proficiencies. Due to high correlations between instruments, a composite language score was used. A specific questionnaire to measure social communication in adults with intellectual disabilities was also utilized.ResultsThe mean nonverbal developmental reference age was 6.5 years, whereas the equivalent for the language measures was about 3.5 years. The prevalence rate of elevated maladaptive behavior was 41% (v-scale score ≥18) and 18% of the participants had a clinically significant score (v-scale score ≥21). Regression analyses showed that only language and social communication skills were significantly associated with maladaptive behavior, while intellectual functioning and adaptive skills were not.ConclusionThese findings emphasize the importance of the constant promotion of communicative skills, as those people with better language and social communication skills demonstrate lower levels of maladaptive behavior.
Magnitude and factors associated with postoperative depression among adult orthopedics patients during COVID-19 pandemics: A multi-center cross-sectional study
Authors: Seid Tegegne Shimelis , Fentie Alle Yewlsew 
Published: July 2022

BackgroundPostoperative depression is one of the devastating problems and important health concerns in adult orthopedics surgical patients. It is often under-diagnosed and appropriate perioperative management of patients is recommended. This study aimed to determine the magnitude and factors associated with postoperative depression among orthopedics patients in Ethiopia.Materials and MethodsThis multi-center cross-sectional study was conducted on 443 adult post-orthopedics surgical patients. All the data were entered and analyzed with SPSS version 25. Bivariable and multivariable logistic regression was used to identify the associated factors with the outcome variable. P-values &lt;0.05 were taken as statistically significant with 95% CI. Data were collected after distributing 9-item standard patient health questionnaires and the Oslo-3 item social support scale tool.ResultBased on our study result, the magnitude of postoperative depression among adult orthopedics surgical patients was 61.8% (95% CI: 56.8–65.7). Using multivariable logistic regression analysis, factors which had an association with postoperative depression were female in gender, Farmer in occupation, having a history of previous substance use, history of anxiety, Patients who had moderate to poor social support, BMI &lt;18.5 kg/m2, and patients who had an open fracture.ConclusionThe magnitude of postoperative depression was high. Due emphasis needs to be given to screening and treatment of postoperative depression, especially among patients of the female gender, farmer occupation, moderate to poor social support, history of substance use and anxiety, low BMI, and open fracture.
Qualitative Research on the Training Experiences and Needs of Intensive Care Unit General Nurses Against the Background of Regular Coronavirus Disease 2019 Prevention and Control
Authors: Zhang Yu , Wang Yan-li , Wang Shu-qin , Zhang Chun-yan , Wan Na , Jia Yan-rui , Gao Feng-li 
Published: July 2022

ObjectiveThis study aimed to investigate the training experiences and needs of intensive care unit (ICU) general nurses against a background of regular Coronavirus disease (COVID-19) prevention and control.MethodsUsing the phenomenological method of qualitative research, semi-structured interviews were conducted with 10 ICU nurses. The interview data were analyzed, sorted, summarized, and refined using the content analysis method.ResultsThe following five themes were extracted from the interviews, based on the training experiences of the nurses: 1) broadening their thinking; 2) discovering their personal shortcomings; 3) gaining self-confidence; 4) calmly facing frontline work; 5) experiencing high assessment pressure. The training needs of the nurses could be summarized into the following four themes: 1) increased training time; 2) improving the assessment mechanism; 3) establishing a normal rotating-shift training system; 4) balancing the teaching levels.ConclusionAgainst a background of regular epidemic prevention and control, ICU training for general nurses is of high practical significance and value. Thus, active exploration and research should be conducted to establish perfect training and assessment mechanisms for these nurses. Additionally, training methods that are suitable for clinical needs should be formulated and training systematization and standardization must be promoted.
Spread of infection and treatment interruption among Japanese workers during the COVID-19 pandemic: A cross-sectional study
Authors: Akashi Jun , Hino Ayako , Tateishi Seiichiro , Nagata Tomohisa , Tsuji Mayumi , Ogami Akira , Matsuda Shinya , Kataoka Masaharu , Fujino Yoshihisa 
Published: July 2022

BackgroundThe COVID-19 pandemic has resulted in treatment interruption for chronic diseases. The scale of COVID-19 in Japan has varied greatly in terms of the scale of infection and the speed of spread depending on the region. This study aimed to examine the relationship between local infection level and treatment interruption among Japanese workers.MethodsCross-sectional internet survey was conducted from December 22 to 26, 2020. Of 33,302 participants, 9,510 (5,392 males and 4,118 females) who responded that they required regular treatment were included in the analysis. The infection level in each participant's prefecture of residence was assessed based on the incidence rate (per 1,000 population) and the number of people infected. Age-sex and multivariate adjusted odds ratios (ORs) of regional infection levels associated with treatment interruption were estimated by multilevel logistic models, nested by prefecture of residence. The multivariate model was adjusted for sex, age, marital status, equivalent household income, educational level, occupation, self-rated health status and anxiety.ResultsThe ORs of treatment interruption for the lowest and highest levels of infection in the region were 1.32 [95 % confidence interval (CI) were 1.09–1.59] for the overall morbidity rate (per 1,000) and 1.34 (95 % CI 1.10–1.63) for the overall number of people infected. Higher local infection levels were linked to a greater number of workers experiencing treatment interruption.ConclusionsHigher local infection levels were linked to more workers experiencing treatment interruption. Our results suggest that apart from individual characteristics such as socioeconomic and health status, treatment interruption during the pandemic is also subject to contextual effects related to regional infection levels. Preventing community spread of COVID-19 may thus protect individuals from indirect effects of the pandemic, such as treatment interruption.
Analysis of the impact of the armed conflict in Ukraine on the population of Romania
Authors: Mărcău Flavius Cristian , Peptan Cătălin , Gorun Horaţiu Tiberiu , Băleanu Vlad Dumitru , Gheorman Victor 
Published: July 2022

PurposeThe study aims to highlight the behavior of people in a state in the vicinity of a military conflict zone. Specifically, it highlights the psychological behavior of Romanian citizens after the invasion of Ukraine by the Russian Federation. It was considered appropriate to carry out this study, given the novelty of such a situation, since, after the end of the Second World War, Europe has no longer faced major problems of insecurity caused by armed conflicts of this magnitude.MethodsThe study was based on the questionnaire applied to a number of 1,193 people with permanent residence in Romania and a minimum age of 18 years. The data were collected in the beginning phase of the invasion of Ukraine by the troops of the Russian Federation, i.e. between March 1–17, 2022. The aim was to obtain information that would allow the observation of re-spondents' opinions on the conflict in Ukraine and its potential escalation, and on the other hand, to allow the assessment of quality of life, using the WHQOL-BREEF measurement instrument.ResultsBased on the results of the study, the highest average satisfaction among the four domains of WHOQOL-BREF is represented by the “Psychological” domain, of the category of people with the lowest fear about a potential future war between Romania and the Russian Federation (83.62 ± 17.48). On the contrary, the lowest average is represented by the “Environment” domain, for the category of persons who do not feel protected by the fact that Romania is a NATO member state (61.77 ± 20.96).ConclusionsThe results of the study show that the indices of the quality of life of the people in Romania, as a state in the proximity of a military conflict with the potential to escalate, are negatively influenced by the fears of people who believe that the war in Ukraine will escalate into a regional or global conflict, or that the Russian Federation is going to use its nuclear arsenal against Ukraine or another NATO member state.
Resistance narratives in patients' accounts of a mandatory pre-operative health optimisation scheme: A qualitative study
Authors: Avery-Phipps Isobel , Hynes Catherine , Burton Christopher 
Published: July 2022

BackgroundPre-operative Health Optimisation is the engagement of patients in health behavior change, such as smoking cessation and weight reduction prior to surgery. Programmes which routinely delay surgery while some patients undergo preoperative optimisation are increasingly used within the UK. Advocates of this approach argue that it reduces perioperative risk and encourages longer term change at a teachable moment. However, critics have argued that mandatory preoperative optimisation schemes may perpetuate or exacerbate inequalities.AimTo understand patients' experience of a mandatory preoperative optimisation scheme at the time of referral for elective surgery.Design and settingQualitative interview study in one area of the UK.MethodParticipants were recruited through GP practices and participating weight-loss schemes. Data was collected from nine semi-structured face-to-face interviews. Thematic analysis was informed by the concept of narratives of resistance.ResultsFour forms of resistance were found in relation to the programme. Interviewees questioned the way their GPs presented the scheme, suggesting they were acting for the health system rather than their patients. While interviewees accepted personal responsibility for health behaviors, those resisting the scheme emphasized that the wider system carried responsibilities too. Interviewees found referral to the scheme stigmatizing and offset this by distancing themselves from more deviant health behaviors. Finally, interviewees emphasized the logical contradictions between different health promotion messages.ConclusionPatients described negative experiences of mandatory pre-operative health optimisation. Framing them as resistance narratives helps understand how patients contest the imposition of optimisation and highlights the risk of unintended consequences.
Is Urology a gender-biased career choice? A survey-based study of the Italian medical students' perception of specialties
Authors: Reale Sofia , Orecchia Luca , Ippoliti Simona , Pletto Simone , Pastore Serena , Germani Stefano , Nardi Alessandra , Miano Roberto 
Published: July 2022

BackgroundDespite the well-established worldwide phenomenon of “the feminisation of medicine,” in Italy, Urology remains a male-dominated field.ObjectiveThe aims of our work are to assess data on medical students' choice of surgical specialty in Italy to investigate if a gender-biased trend exists and to find the key points that influence the decision-making process when choosing a specialty, with a focus on Urology.DesignData about access to residency programs in 2017–2020 were analysed through descriptive statistics. Investigations concerning the decision-making process were carried through distribution of an online anonymous survey to Italian medical students.ResultsUrology was among the specialties with the lowest proportion of female residents in Italy in the last 4 years: 37 (29.4%) in 2017, 27 (21.4%) in 2018, 40 (26.7%) in 2019, and 57 (25.2%) in 2020. The total number of participants of the survey was 1409, of which only 341 declared being keen to pursue a career path in surgery. Out of the 942 students not interested in surgery, 46.2% females and 22.5% males indicated a “sexist environment” as one of the reasons. Overall, the main reason for medical students not choosing Urology is the lack of interest in the specialty. Furthermore, there is a different perception of Urology as a sexist environment between female (23.4%) and male (3.2%, p &lt; 0.001) medical students, which may influence their decision-making process.ConclusionsIn Italy, the prevalence of female medical graduates does not mirror the proportion of female doctors choosing a career in some surgical specialties, including Urology. Our survey results clearly identified that a large proportion of medical graduates are not choosing urology because of the perception of a sexist environment. While the reasons for this phenomenon remain unclear, the presence of a gender-biased perception of a sexist environment represents a possible explanation.
Incidencia de la clase invertida en el desarrollo del pensamiento crítico
Authors: Pincay Parrales Maria Leonela 
Published: July 2022

La clase invertida al ser considerada una metodología activa, propicias actividades participativas, de refuerzo y colaboración antes, durante y fuera del salón de clase. La presente investigación tiene como objetivo establecer la incidencia de la clase invertida en el desarrollo del pensamiento crítico en los estudiantes que cursan el tercer semestre de la Facultad de Arquitectura y Urbanismo de la Universidad Central del Ecuador. Evidenciando que, la metodología que empleó el docente puede generar criticidad en el estudiante, dando como resultado un aprendizaje autónomo que motiva la solución de los problemas. Es aquí, donde el docente cumple el rol de guía, bajo el principio de enseñar a aprender, de manera que, el desarrollo de destrezas de orden superior sea una prioridad en esta fase. Por lo tanto, se dio lugar a una investigación cuasi experimental, donde se aplicó un pre y post test que, determinó el nivel de pensamiento crítico del estudiante bajo tres parámetros: Interpretación y análisis de información, Juicio de una situación con datos objetivos y subjetivos e Inferencia de consecuencias de la decisión basándose en el juicio autorregulado; cuyo resultado, además, se sustentó con el uso de fichas de observación y listas de cotejo.
PALABRAS CLAVE: clase invertida; metodología; pensamiento crítico.
Flipped classroom incidence in the critical thinking development
ABSTRACT
The flipped classroom is considered an active methodology that promotes participatory, enhancement and collaborative activities before, during and outside the classroom. The aim of this research is to establish the flipped classroom incidence in the development of critical thinking in the third semester from Architecture and Urbanism Faculty in Central University of Ecuador. Proving that, the methodology used by the teacher can generate criticality in students resulting in autonomous learning that leads to solve problems. This is where the teacher fulfills the role of a guide based on teaching to learn principle, so that, the development of higher order skills is a priority in this phase. Therefore, quasi-experimental research was carried out, where a pretest and post-test were applied. It determined the level of student´s critical thinking established on three parameters: Interpretation and information analysis, judgment of a situation with objective and subjective data and inference of consequences of the decision based on the self-regulated trial; whose result also, was sustained using observation techniques and checklists.
KEYWORDS: flipped classroom; methodology; critical thinking.
Reinventando el museum, críticas de la nueva museología
Authors: Lanas Lastra Vanessa Belén 
Published: July 2022

El presente artículo analiza críticamente, el papel del museo, cambios y características que lo han llevado a convertirse en el centro de debate de las últimas décadas. Siendo el sector cultura uno de los más afectados por la pandemia es necesario transformarlo en un espacio de diálogo y participación; fomentando así alternativas de acción a tomar en cuenta para afianzar la comunicación entre objeto, museo y visitante.
Competencia digital y desempeño docente en el Perú
Authors: Portuguez Herrera Jessica Maximiliana , Medina de Véliz Liliana Francis León , Alanya Coras Eulogio , Castro Palomino Luis 
Published: July 2022

La presente investigación tiene como objetivo determinar la relación que existe entre la competencia digital y el desempeño docente en el colegio “José Buenaventura Sepúlveda Fernández”, Cañete, 2021, en este estudio se ha utilizado un diseño transversal, descriptivo correlacional no experimental, de tipo básico, bajo un enfoque cuantitativo y para ello emplea un método hipotético deductivo. La demostración de la investigación está compuesta de 71 docentes de la I.E. “José Buenaventura Sepúlveda Fernández”, Cañete en el año 2021. Se empleó cuestionarios adaptados y verificados por juicio de tres expertos para estimar la comprensión docente, quienes publicaron su idoneidad, Con su respectiva validez y fiabilidad de Alfa de Cronbach. Los resultados analizados indicaron que existe una correlación moderada entre las variables con un Rho de Spearman de ,512 y una significación bilateral de ,000. Aceptando la hipótesis alterna y denegando la hipótesis nula.
PENGARUH INHIBITOR SISTEIN PADA FERMENTASI BIJI KAKAO TERHADAP KANDUNGAN POLIFENOL
Authors: Nurhayati Dewi , Mulia Yuliansyah Sundara , Azhiima Amadda Fadhila 
Published: July 2022

Obesity is a condition of excessive accumulation of fat in the body. Dietary fiber and anthocyanins have beneficial effects on obesity. The aim was to determine the effect of the product's formulation of oat flour and fermented glutinous black rice on organoleptic aspects, dietary fiber content, and anthocyanin content. This research design used an experimental study with a completely randomized design. This research method used a hedonic test on 30 panelists to determine organoleptic properties, pH differential for anthocyanin levels, and enzymatic gravimetric for dietary fiber levels. The formulation between oat flour and fermented glutinous black rice obtained was F1 (30:70), F2 (50:50), and F3 (70:30). F2 product has the best rating on all organoleptic aspects, including color, aroma, texture, taste, and overall. The results of the Kruskal Wallis test showed a significant difference in the texture aspect of the product. The anthocyanin content in the product is 5.72 mg/100 grams, and the fiber content in the product is 7.36%. It is hoped that further research will be carried out to determine the effectiveness of oat fermented glutinous black rice cookies on samples with obesity.
ẢNH HƯỞNG CỦA MÔ HÌNH ĐỘ NHỚT RỐI LÊN MÔ PHỎNG DÒNG XÂM THỰC TRONG NƯỚC Ở NHIỆT ĐỘ CAO
Authors: Anh Lê Đình , Quân Nguyễn Hoàng , Long Ngô Ích , Thuận Trương Văn , Anh Trương Việt 
Published: July 2022

Nghiên cứu này đánh giá ảnh hưởng của các mô hình rối lên mô phỏng dòng xâm thực trong môi trường nước ở nhiệt độ cao. Dòng chảy qua biên dạng cánh NACA0015 được mô phỏng sử dụng mô hình đồng nhất cho dòng nén được, ba pha nước - hơi bão hòa - khí không hòa tan. Ba mô hình độ nhớt rối được tính toán bao gồm mô hình độ nén, mô hình sửa đổi Reboud và mô hình VLES. Mô phỏng được thực hiện với nước ở nhiệt độ 25oC, 50oC và 70oC với góc tấn 5o và 8o. Kết quả mô phỏng được so sánh tương quan với kết quả thực nghiệm của phân bố hệ số áp suất -Cp trên cánh của Cervone và các cộng sự ở hệ số xâm thực s = 2.5 và 1.5. Kết quả cho thấy mô hình hóa độ nhớt rối có tác động lớn đến sự phân bố tỉ lệ thể tích khí xâm thực và phân bố năng lượng rối trên biên dạng cánh. Ba mô hình độ nhớt rối cho kết quả phân bố hệ số áp suất -Cp tốt so với thực nghiệm. Trong đó, mô hình độ nén cho kết quả tốt nhất so với thực nghiệm ở các nhiệt độ khác nhau.