bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary evaluation of acute myeloid leukemia patients with long‐term survival exceeding 5 years
Authors: Heering Gabriel , Sasson Maya , Dominissini Dan , Shimoni Avichai , Avigdor Abraham , Nagler Arnon , Canaani Jonathan 
Published: September 2022

AbstractObjectivesDefine clinical and laboratory attributes of acute myeloid leukemia (AML) patients with long‐term survival exceeding five years and compare them with AML patients succumbing to disease within 2 years of diagnosis.MethodsA retrospective analysis of AML patients alive at least five years from the time of initial diagnosis. Baseline clinical data were compared with patients who died within 2 years of diagnosis.ResultsThe long‐term cohort consisted of 93 patients treated in 2007–2016 with a median follow‐up duration of 7.7 years (range 5–13.6 years). European LeukemiaNet (ELN) 2017 favorable risk patients accounted for 60% of the cohort. All long‐term survivors achieved remission following induction chemotherapy. Multivariate analysis showed that compared with 132 patients experiencing death within 2 years of diagnosis, long‐term survivors were more likely to be of younger age [odds ratio (OR), 0.92; 95% confidence interval (CI), 0.9–0.95; p < 0.001], have a lower initial WBC count (OR, 0.58; 95% CI, 0.43–0.79; p = 0.0004), undergo an allogeneic stem cell transplantation (OR, 7.95; 95% CI, 3.07–20.59; p < 0.0001), and harbor favorable risk cytogenetics (OR, 0.03; 95% CI, 0.006–0.23; p = 0.0004).ConclusionsLong‐term survival of AML is seen in a distinct demographic and biologic patient subset.
Long‐term no‐tillage and rye cover crops affect soil biological indicators on Andosols in a humid, subtropical climate
Authors: Gong Yingting , Li Peiran , Guo Yong , Aso Hiyori , Huang Qiliang , Araki Hajime , Nishizawa Tomoyasu , Komatsuzaki Masakazu 
Published: September 2022

AbstractThe effects of tillage and cover crop management on the physical and chemical properties of soil are well‐documented. However, the responses of soil microbes to long‐term tillage and crop rotation schemes still need clarification. The objective of this study was to determine the effects of different tillage and cover crop systems on soil biological indicators and their interactions in Andosols in a humid subtropical climate in Japan. This study was conducted during a field trial established in 2002. The main factors were tillage systems (no‐tillage [NT] and mouldboard ploughing [MP]); the subplot was winter cover crop treatments (bare fallow [FA] and rye [RY]) succeeding summer soya bean. Soil microbial biomass, community and structure, and soil organic carbon (SOC) stock were assessed, as well as soil respiration in the past 2.5 years. Overall, the NT and RY systems increased the soil respiration and SOC stocks relative to those detected in the MP and FA systems. After being differentiated for 18 years, the tillage systems showed a greater influence on the soil microbial community and biomass than cover crop treatments. These tillage systems significantly altered the bacterial alpha diversity (NT > MP) and soil microbial biomasses (NT > MP) based on soil Adenosine 5′‐triphosphate content, substrate‐induced respiration and ergosterol content. The NT and RY treatments stimulated soil respiration by positively affecting plant residue retention, SOC stocks, bacterial alpha diversity, soil microbial biomass in summer, and the relative abundance of organic matter decomposers, such asBacteroidetes‐,Basidiomycota‐andAscomycota‐related species. These results suggest that the NT and RY systems helped improve the soil microbial properties of Andosols in a humid subtropical climate in Japan. However, their potential vulnerability to SOC sequestration due to elevated soil respiration needs further clarification, especially in the context of global warming.HighlightsSoil microbe responses to agricultural measures on Andosols were studied.No‐tillage and rye cover crops stimulated soil respiration.No‐tillage shifted the soil microbial community more than cover crops.No‐tillage improved the soil organic carbon stock and bacterial alpha diversity.
Solo‐living and childless professional women: Navigating the ‘balanced mother ideal’ over the fertile years
Authors: Wilkinson Krystal , Rouse Julia 
Published: September 2022

AbstractOne in five women are childless at midlife, and for an estimated 90 percent of these women, childlessness is not actively chosen. In this article, we explore how solo‐living and childless professional women navigate the ‘balanced mother ideal’ over their fertile years and what this means for organizations and organization studies. Drawing on biographical narrative interview data from solo‐living professional women in the UK, we argue that identifications with the balanced mother ideal change over the life course as a result of futurity, ambivalence, and suppression of negative emotions—part of the logic of both postfeminism and neoliberal feminism—and the ‘disenfranchized grief’ of contingent childlessness. At the point of late fertility, the absence of alternative social narratives to the balanced mother ideal appears to create a crisis point for childless women, including in the workplace. We conclude our article with recommendations for how organizations can better cater to the needs of this significant, yet largely silenced, demographic group.
Comparison between the impact of tenofovir alafenamide and that of abacavir on rapid kidney function decline: A retrospective observational study
Authors: Hikasa Shinichi , Shimabukuro Shota , Hideta Kyoko , Higasa Satoshi , Sawada Akihiro , Tokugawa Tazuko , Tanaka Kuniyoshi , Yanai Mina , Kimura Takeshi 
Published: September 2022

AbstractObjectivesTo compare the impact of tenofovir alafenamide (TAF) on the slope of the estimated glomerular filtration rate (eGFR) with that of abacavir in Japanese patients living with HIV infection.MethodsThe participants in this single‐centre, retrospective, observational study were Japanese patients with HIV infection who started antiretroviral therapy with TAF/emtricitabine or abacavir/lamivudine or were switched from tenofovir disoproxil fumarate/emtricitabine to TAF/emtricitabine or abacavir/lamivudine (anchor drugs remained constant) between January 2012 and December 2020. The eGFR slope was defined as the regression coefficient between eGFR and time. The study outcome was rapid kidney function decline (RKFD; eGFR slope < −5 mL/min/1.73 m2/year). The adjusted effect of TAF on the eGFR slope was compared with that of abacavir using multivariate logistic regression analysis.ResultsThe study included 184 patients (with 2835 eGFR data points). The median duration of exposure to TAF or abacavir was 2.6 years [interquartile range (IQR): 1.7–3.3], and the median eGFR slope was −4.1 mL/min/1.73 m2/year (IQR: −6.4 to −1.2). In all, 72 patients (39%) experienced RKFD. Patients receiving TAF were more likely to experience RKFD (adjusted odds ratio = 3.74) than those receiving abacavir. There was a significant independent association between baseline eGFR and RKFD.ConclusionsThese findings suggest that renal function should be monitored carefully after the initiation of TAF in Japanese patients with HIV infection.
The nature of the Moho beneath fast‐spreading centers: Evidence from the Pacific plate and Oman ophiolite
Authors: Tamura Yoshihiko , Rospabé Mathieu , Fujie Gou , Ohira Akane , Kaneda Kentaro , Nichols Alexander R. L. , Ceuleneer Georges , Sato Tomoki , Kodaira Shuichi , Miura Seiichi , Takazawa Eiichi 
Published: September 2022

AbstractIt is common knowledge that the Moho is the boundary between the crust and the Earth's mantle. Here we show along several seismic profiles through the Pacific Plate that a correlation exists between the strength of Moho reflections, crustal thickness, and water depth. Where the Moho can be detected clearly, the overlying oceanic crust is systematically thicker and the water depths are shallower. We suggest that two end‐members of oceanic crust exist in fast spreading environments: one thick, underlain by a clear Moho; the other thinner, without a Moho; with all intermediate situations. In the Oman ophiolite, the best‐preserved on‐land analogue of fossil oceanic lithosphere created by fast‐spreading, the boundary between the mantle peridotites and the lower crustal gabbros mainly consists of a dunitic transition zone (DTZ) ranging from a few meters to a few hundred meters in thickness. A sudden influx of seawater down to the base of the crust at the mid‐ocean ridge (MOR) results in the hydrous (re‐)melting of mantle peridotites, producing a dunitic residue at the crust–mantle boundary that represents the most reflective Moho. At the same time, the hydrous melting, in addition to the normal decompression melting, beneath the MOR, increases the thickness of the oceanic crust by enhancing magma production. In the absence of hydrous melting, the DTZ is thin or absent at the crust–mantle boundary, and instead the uppermost mantle harzburgite is intruded by gabbros, and/or the overlying crustal gabbro is intruded by numerous wehrlite bodies, which will be seismically gradational.
Preparation and characterization of novel nano‐Al2O3/SiO2‐based composites for energy‐saving
Authors: Liu Jingfei , Li Yuanbing , Yin Bo , Li Shujing , Chen Pan 
Published: September 2022

AbstractNano‐porous super thermal insulation composites are an important component in refractory and play a key role in energy‐saving. In this work, we adopt dry preparation technology and high‐temperature sintering and use nano‐Al2O3 and nano‐SiO2 as the main materials to prepare nano‐Al2O3/SiO2‐based composites for a range of performance characterization. According to this study, the as‐prepared nano‐Al2O3/SiO2‐based composites exhibited a high porosity (77.4%–89.6%) and a low thermal conductivity (.06–.134 W/(m k) at 200–800°C). The most striking finding of this study was the nanostructure that was successfully constructed in nano‐Al2O3/SiO2‐based composites and exhibited a well hierarchical aperture distribution. The as‐prepared nano‐Al2O3/SiO2‐based composites could be widely applied in energy‐saving and heat preservation applications.
Longitudinal associations between weight status and academic achievement in primary school children
Authors: Watson Amanda , D'Souza Ninoshka J. , Timperio Anna , Cliff Dylan P. , Okely Anthony D. , Hesketh Kylie D. 
Published: September 2022

SummaryBackgroundEvidence for longitudinal associations between childhood weight status and academic achievement remains unclear due to considerable heterogeneity in study design, measures of academic achievement and appropriate categorization of weight status.ObjectiveTo examine longitudinal associations between childhood weight status (underweight, healthy weight, overweight/obese) and academic achievement in the transition from preschool to primary (elementary) school among Australian school children.MethodsData were from the Healthy Active Preschool and Primary Years study. Height and weight, for calculating BMI were measured at baseline (preschool age 3–5 years; 2008/9) and follow‐up (primary school age 6–8 years; 2011/12). Academic achievement was measured at age 9 years.ResultsNo associations between BMI z‐score or weight category in the preschool years and later NAPLAN scores were found for boys. For girls, having a higher BMI z‐score (B = −13.68, 95%CI: −26.61, −0.76) and being affected by overweight (B = −33.57, 95%CI: −61.50, −5.24) in preschool was associated with lower language scores. Remaining affected by overweight from preschool to primary school was associated with lower numeracy (B = −25.03, 95%CI: −49.74, −0.33), spelling (B = −33.5, 95%CI: −63.43, −3.58), language (B = −37.89, 95%CI: −72.75, −3.03) and total achievement scores (B = −24.24, 95%CI: −44.85, −3.63) among girls. For boys, becoming affected by overweight was associated with lower spelling (B = −38.76, 95%CI: −73.59, −3.93) and total achievement scores (B = −27.70, 95%CI: −54.81, −0.58).ConclusionsAssociations between being affected by overweight/obesity and poorer academic achievement were more pronounced in girls than boys, indicating potentially inequitable impacts of excess weight and highlighting the greater need for intervention among girls. However, stronger study designs are needed to confirm our findings.
Impact of intracardiac echocardiography on readmission morbidity and mortality following atrial fibrillation ablation
Authors: Deshpande Saurabh , Sawatari Hiroyuki , Ahmed Raheel , Nair Rakesh Gopinathan , Khan Hassan , Khanji Mohammed Y. , Somers Virend K. , Chahal C. Anwar A. , Padmanabhan Deepak 
Published: September 2022

AbstractIntroductionThe use of intracardiac echocardiography (ICE) is beneficial during the ablation of atrial fibrillation (AF). Evidence is conflicting regarding the clinical impact of using ICE on arrhythmia recurrence and mortality.MethodsPatients undergoing catheter ablation of AF during 2010–2017 were identified using the International Classification of Diseases‐9th and 10th Revision‐Clinical Modification (ICD‐9‐CM and ICD‐10‐CM) from the Nationwide Readmissions Database. Propensity matching was used to generate a control group. Patient demographics, Charlson comorbidity indexes, time from discharge to readmission, and the reason of readmission were extracted.ResultsFrom 2010 to 2017, 51 129 patients were included in the analysis out of which ICE was used in 8005 (15.7%) patients. The in‐hospital mortality at readmission was significantly higher in the patients without ICE use (2.9% vs. 1.7%, p = .02). The length of stay (LOS) at readmission was significantly higher in non‐ICE arm (median [interquartile range, IQR]: 3 [2–6] vs. 2 [3–5] days, p < .0001) with similar healthcare‐associated cost (HAC) in both the groups (median [IQR]: US$7507.3 [4057.8–15 474.2] vs. 7339.4 [4024.8–15 191.6], p = .43). Freedom from readmission was 12% higher (hazard ratio [HR] [95% confidence interval, CI]: 0.88 [0.83–0.94], p < .0001) with the use of ICE at 90‐day follow‐up, which was driven by 24% reduction in heart failure (HF) at follow‐up (HR [95% CI]: 0.76 [0.60–0.96], p = .02).ConclusionsICE use during AF ablation procedure reduces readmissions at 90 days by 12%, driven by a 24% decrease in HF‐related admissions. The non‐ICE arm showed a significantly higher LOS which offsets marginally higher HAC in the ICE arm.
Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
Authors: Yu Changhui , Zhou Zicong , Huang Wufeng , Li Xiumei , Zou Fei , Meng Xiaojing , Cai Shaoxi 
Published: September 2022

AbstractOrai family are a calcium channel of cell membrane extracellular Ca2+ influx which participates in tissue fibrosis. But the roles of Orai3 have less attention on the mechanism of regulating lung fibrosis. In this study, we found that Orai3 expression was increased significantly in BLM‐induced lung fibrosis. The knockdown of Orai3 decreased TGF‐β1‐induced fibroblast proliferation, ECM production, activation of NFAT1 and Calpain/ERK signal pathway and glycolysis levels. Orai3 interacting with Orai1 was increased in BLM‐induced lung fibrosis and TGF‐β1‐induced fibroblast, while the Stim1 interacting with Orai1 and SOCE activity was suppressed, leading in a high and stable extracellular Ca2+ influx. Furthermore, the over‐expression of Orai3 did not enhance Orai3 interacting with Orai1 under TGF‐β1 free fibroblast. And then, the deeper mechanism of TGF‐β1‐induced increased SEPTIN4 promoted Orai3 interacting with Orai1. Our results indicated that Orai3 could be one of the therapy targets for PF in which remodels Orai channel, suppresses SOCE activity and activated fibroblast to alleviate fibrosis progress.
Delayed regression of laser‐induced choroidal neovascularization in TNFα‐null mice
Authors: Iwanishi Hiroki , Yamanaka Osamu , Sumioka Takayoshi , Yasuda Shingo , Miyajima Masayasu , Saika Shizuya 
Published: September 2022

AbstractWe investigated the effects of lacking TNFα on the development and regression of Argon‐laser‐induced choroidal neovascularization (CNV) in mice. We lasered ocular fundus for induction of CNV in both wild‐type (WT) and TNFα‐null (KO) mice. Fluorescence angiography was performed to examine the size of CNV lesions. Gene expression pattern of wound healing‐related components was examined. The effects of exogenous TNFα on apoptosis of human retinal microvascular endothelial cells (HRMECs) and on the tube‐like structure of the cells were investigated in vitro. The results showed that Argon‐laser irradiation‐induced CNV was significantly larger in KO mice than WT mice on Day 21, but not at other timepoints. Lacking TNFα increased neutrophil population in the lesion. The distribution of cleaved caspase3‐labelled apoptotic cells was more frequently observed in the laser‐irradiated tissue in a WT mouse as compared with a KO mouse. Exogenous TNFα induced apoptosis of HRMECs and accelerated regression of tube‐like structure of HRMECs in cell culture. Taken together, TNFα gene knockout delays the regression of laser‐induced CNV in mice. The mechanism underlying the phenotype might include the augmentation of neutrophil population in the treated tissue and attenuation of vascular endothelial cell apoptosis.
Erythrina stem borer moth in California – New taxonomic status and implications for control of this emerging pest
Authors: Sourakov Andrei , Zhang Jing , Cong Qian , Song Leina , Grishin Nick V. 
Published: September 2022

AbstractDuring the last 10 years, the Erythrina stem borer moth, Terastia meticulosalis, emerged as a pest of cultivated coral trees (Erythrina spp.) in California. Erythrina trees are valued for their moderate drought resistance and beautiful flame‐like flowers. They are beloved enough to be considered Los Angeles's official “City Tree.” Thus, they are a valuable horticultural crop and are grown by many nurseries and occur throughout the landscape in coastal southern California. Coral trees have been heavily affected by T. meticulosalis recently. Using whole genome sequencing techniques, we analysed the origins of this and other infestations of Erythrina in coastal areas and found that they have likely originated from the repeated expansions of the native range of the species in Arizona, a process possibly driven by climatic factors and/or movement of plants by humans. We also found sufficient genetic differences between the western population of the moth and the rest of the New World populations to describe a new western subspecies, T. meticulosalis occidentalis Sourakov & Grishin ssp. n. (type locality USA: CA, San Diego Co., La Jolla). These findings are of economic importance for future attempts to control the moth's impact on activities surrounding the horticultural use of Erythrina spp. by the Californian landscape and nursery industries.
Optimization of process variables for preparation of horse gram flour incorporated high fiber nutritious biscuits
Authors: Joshi Homi , Awasthi Pratima , Shahi Navin C. 
Published: September 2022

AbstractThe present study aims at optimizing the process variables for development of horse gram flour incorporated biscuits, high in protein and dietary fiber. Box–Behnken design was employed to optimize the levels of three independent variables viz. flour: fat ratio, % whole wheat flour (WWF) replaced by horse gram flour (HF) and baking time (minutes) and their effects were determined over the response parameters that is, overall acceptability, fat content (g/100 g), dietary fiber (g/100 g), hardness and color difference (ΔE). Results showed that increasing the flour: fat ratio and % of WWF replaced by HF significantly decreased (p < 0.05) the overall acceptability. Fat content of biscuits was also significantly affected by the flour: fat ratio and % of HF. The hardness and dietary fiber content of biscuits was found to be positively correlated with flour: fat ratio and % WWF replaced by HF. It was observed that prolonging the baking time led to an increase (p < 0.05) in the hardness and color difference of biscuits. The optimized nutritious biscuits were obtained at flour: fat ratio 4.15:1, 23.5% WWF replaced by HF and baking time 29 min. Horse gram flour incorporated biscuits thus optimized were high in dietary fiber (9.37 g/100 g) and low in fat (16.41 g/100 g). Other responses predicted in terms of OA, hardness and color difference (ΔE) were 7.03, 31.53 N and 8.01 respectively. The study thus explains that the under‐utilized grain legume – horse gram can be successfully incorporated to develop fiber rich nutritious biscuits with good consumer acceptability.Novelty Impact StatementIn this study, response surface methodology (RSM) was used to develop and optimize horse gram flour incorporated biscuits by supplementing horse gram flour to whole wheat flour in different ratios. These biscuits being high in dietary fiber, protein and low in fat may be a better alternative for the commercially available biscuits, especially for the diabetics. Also, this may improve the status of underutilized indigenous legume horse gram.
Endoscopic radial incision versus endoscopic balloon dilation as initial treatments of benign esophageal anastomotic stricture
Authors: Zhang Zhao‐Chao , Xu Jia‐Qi , Xu Jia‐Xin , Xu Mei‐Dong , Chen Shi‐Yao , Zhong Yun‐Shi , Zhang Yi‐Qun , Chen Wei‐Feng , Ma Li‐Li , Qin Wen‐Zheng , Hu Jian‐Wei , Cai Ming‐Yan , Yao Li‐Qing , Li Quan‐Lin , Zhou Ping‐Hong 
Published: September 2022

AbstractBackground and AimWe aim to evaluate the efficacy and safety of endoscopic radial incision (ERI) versus endoscopic balloon dilation (EBD) treatment of naïve, recurrent, and refractory benign esophageal anastomotic strictures.MethodsOne hundred and one ERI, 145 EBD, and 42 ERI combined with EBD sessions were performed in 136 consecutive patients with benign esophageal anastomotic stricture after esophagectomy at Zhongshan Hospital from January 2016 to August 2021. Baseline characteristics, operational procedures, and clinical outcomes data were retrospectively evaluated. Parameters and recurrence‐free survival (RFS) were compared between ERI and EBD in patients with naïve or recurrent or refractory strictures. Risk factors for re‐stricture after ERI were identified using univariate and multivariate analyses.ResultsTwenty‐nine ERI versus 68 EBD sessions were performed for naïve stricture, 26 ERI versus 60 EBD for recurrent strictures, and 46 ERI versus 17 EBD for refractory stricture. With comparable baseline characteristics, RFS was greater in the ERI than the EBD group for naïve strictures (P = 0.0449). The ERI group had a lower 12‐month re‐stricture rate than the EBD group (37.9% vs 61.8%, P = 0.0309) and a more prolonged patency time (181.5 ± 263.1 vs 74.5 ± 82.0, P = 0.0233). Between the two interventions, recurrent and refractory strictures had similar RFS (P = 0.0598; P = 0.7668). Multivariate analysis revealed initial ERI treatment was an independent predictive factor for lower re‐stricture risk after ERI intervention (odds ratio = 0.047, P = 0.001). Few adverse events were observed after ERI or EBD (3.0% vs 2.1%, P = 0.6918).ConclusionsERI is associated with lower re‐stricture rates with better patency and RFS compared with EBD for naive strictures.