bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping the complex everyday challenges and needs of people with rheumatic disease and their surroundings using a multi‐actor approach
Authors: Harmsen Simone , Nabuurs Joyce A. , Lehman de Lehnsfeld Lotte F. , van der Meij Marjoleine G. , Broerse Jacqueline E. W. , Pittens Carina A. C. M. 
Published: April 2022

AbstractIntroductionThis study aimed to gain insight into the real‐world complexity of the challenges experienced by patients, their significant others, care professionals and the work and education environment concerning rheumatic diseases as well as the interrelation between these challenges; it also aimed to prioritise the identified challenges.MethodUsing the Dialog Model, 21 people with various rheumatic diseases, 24 care professionals, 9 significant others, and 3 education and work representatives were asked about rheumatic disease‐related challenges and needs in a series of focus groups and interviews. Data were inductively coded and analysed, resulting in a mind map thematically displaying the challenges. The mind map was translated into a survey, and respondents (N = 1802) prioritised themes and challenges.ResultsOf the six identified themes, ‘physical complaints’ was prioritised the most, followed by ‘collaboration in healthcare’, ‘social and mental wellbeing’, ‘self‐management’, ‘information and options in healthcare’ and ‘work and education’. Challenges of people with rheumatic diseases appeared to be complexly interrelated. For instance, fatigue and pain affect everyday functioning, but can also heavily impact social and mental wellbeing. To facilitate support for these challenges, which many patients desire, patients and care professionals said that better collaboration between primary and secondary care professionals is needed. Additionally, patients felt that their experiential expertise deserves more acknowledgement from care professionals. Results were similar across different rheumatic diseases.ConclusionMany patients desire more support to manage life with their disease. To facilitate this, collaboration and communication between healthcare professionals, and between healthcare professionals and individual patients, should be improved.
Persistent storage symptoms following Y‐V plasty reconstruction for the treatment of refractory bladder neck contracture
Authors: Shamout Samer , Yao Henry H. I. , Mossa Abubakr H. , Carlson Kevin V. , Baverstock Richard J. 
Published: April 2022

AbstractPurposeRefractory bladder neck contracture (BNC) following transurethral prostatectomy is rare and difficult to manage. Success rate of endoscopic treatment decline considerably after repeated treatments. Bladder neck reconstruction are often the last resort to treat refractory BNC failing endoscopic treatments. In general, experience is limited with this type of bladder neck reconstruction, particularly in adult patients. This study aims to determine the success rate, functional and patient‐reported outcomes (PRO) of open Y‐V plasty in treatment of refractory BNC after transurethral prostatectomy. The study also aims to determine the rate, and potential predictors of persistent storage symptoms after Y‐V plasty.Materials and MethodsBetween January 2016 and February 2021, 18 consecutive patients with refractory BNC who underwent open Y‐V plasty were included in this study. All patients presented with voiding dysfunction after two or more failed attempts of endoscopic treatments followed by a 3‐month period of outpatient serial dilation program. Clinicopathological data were extracted from medical records including baseline demographics, aetiology of BNC, previous endoscopic treatment, operative time, length of stay, complications, uroflow findings, International Prostate Symptom Score (IPSS) and OAB‐V8. Primary outcome was the success of open YV plasty, defined as no need for further instrumentation such as indwelling catheterization, urethral dilatation, urethrotomy, or open surgery. Simple linear regression analysis was performed to determine predictor factors for postoperative OAB‐V8. Variables that showed p < 0.25 were included in the multiple linear regression analysis.ResultsMost common aetiology of BNC was transurethral resection of prostate gland (n = 18, 100%). Mean age at surgery age (SD) was 65.5 (7.3) years. Mean follow‐up was 14.8 (7) months. Success rate was 100%. Postoperative Qmax improved significantly [pre‐OP 6.7 (8.1) ml/s vs. post‐OP was 14.8 (7.3) ml/s, p < 0.001]. Mean postvoid residual decreased significantly [pre‐OP 223.3 (254.3) ml vs. post‐OP 45.1 (71.0) ml, p < 0.01)]. Persistent storage symptoms were reported in 61% of patients. BMI and baseline IPSS score are significant predictors for the postoperative OAB V8 change (adjusted b (95% confidence interval) = 1.037 (0.2–1.9), 0.64 (0.28–0.99), respectively, R2 = 0.59).ConclusionY‐V plasty reconstruction for refractory BNC represents a feasible and successful option with high success rate and favorable outcomes. While functional and patient‐reported outcomes had significantly improved post‐operatively, persistent storage symptoms after this procedure still exist. BMI and baseline IPSS score are significant predictors for persistent storage symptoms after bladder neck reconstruction.
Prevalence of lower urinary tract symptoms in children with early‐treated infantile‐onset Pompe disease: A single‐centre cross‐sectional study
Authors: Chen Yu‐Kuang , Teng Chao‐Ting , Yang Chia‐Feng , Niu Dau‐Ming , Huang William J. , Fan Yu‐Hua 
Published: April 2022

AbstractAimTo evaluate lower urinary tract symptoms (LUTS) in children with infantile‐onset Pompe disease (IOPD) who received early treatment.MethodsPompe disease (PD), or glycogen storage disease II is a rare autosomal recessive lysosomal storage disease that affects multiple organ systems. To our knowledge, only one study has focused on the relationship between LUTS and incontinence in children with PD. This cross‐sectional study was conducted from August 2019 through March 2021 and children with IOPD, who had received early and regular enzyme replacement therapy, were enrolled. Participants or their parents completed the Dysfunctional Voiding Scoring System (DVSS) questionnaire. All children underwent uroflowmetry and postvoid residual urine measurements. Fourteen children (age, 4–9 years) with IOPD were enrolled.ResultsTen patients (71.4%) had abnormal uroflow curves. In addition, results of the DVSS revealed that approximately half (42.9%) of our IOPD patients had voiding dysfunction, with urinary incontinence as the most common symptom (64.3%, 9/14). No significant correlations were found between LUTS and uroflow curves in children with IOPD.ConclusionsThe frequency of LUTS and lower urinary tract dysfunction noted on uroflowmetry should encourage pediatricians to actively identify IOPD patients with LUTS, regardless of the timing and frequency of their treatments, and refer them to a urologist for further evaluation and appropriate treatment.
Looking at the nonprofit accountability‐charitable donations relationship through the publicness lens
Authors: Hoang Trang , Lee Young‐Joo 
Published: April 2022

AbstractThis study integrates the publicness theory and the benefits theory of nonprofit finance to examine how nonprofits' financial and non‐financial accountability criteria relate to the private charitable contributions they receive. The analysis of the National Center for Charitable Statistics' IRS Statistics of Income Sample Files 2008–2012 and Nonprofit IRS E‐filers 2010–2017 reveals that the relationships between accountability criteria and private donations vary significantly depending on the nonprofits' funding structure and service type. In particular, financial ratios are more strongly associated with charitable contributions with more commercially funded nonprofits, while contributions to organizations relying more on noncommercial revenues are better explained by the adoption of good governance policies. The findings also reveal differences depending on the nature of nonprofit services, as financial ratios are more strongly associated with donations to organizations providing private benefits than with donations to nonprofits providing mixed or public benefits.
Giving voice to children in research: The power of child‐centered constructivist grounded theory methodology
Authors: Sudarsan Indu , Hoare Karen , Sheridan Nicolette , Roberts Jennifer 
Published: April 2022

AbstractThere has been a growing interest in giving voice to children in response to the introduction of the United Nations Convention on the Rights of the Child and evolving sociological discourses on childhood. Using child‐sensitive methodologies such as constructivist grounded theory (CGT) enables children's voices to contribute authentic, meaningful, and eventually more actionable data, capable of informing policies and practices in children's best interests. In this article, we discuss how researchers using CGT can privilege children's voices through effective knowledge coconstruction by creating a child‐sensitive research space and using methods that are appropriate to their abilities and interests. We draw on selected data from the first author's (I. S.) PhD project that explores Indian immigrant children's and their family carers' beliefs, practices, and experiences of asthma in New Zealand. We encourage researchers to consider CGT as one of the appropriate methodological choices to explicitly promote the voice of the child.
Electrocardiographic abnormalities in childhood cancer survivors treated with cardiotoxic therapy: a systematic review
Authors: de Baat Esmée C. , Feijen Elizabeth A.M. , van Niekerk Jorrit B. , Mavinkurve‐Groothuis Annelies M.C. , Kapusta Livia , Loonen Jacqueline , Kok Wouter E.M. , Kremer Leontien C.M. , van Dalen Elvira C. , van der Pal Helena J.H. 
Published: April 2022

AbstractPurposeThe purpose of this study is to assess the available literature on the prevalence and risk factors of electrocardiographic (ECG) abnormalities after cardiotoxic treatment in childhood cancer survivors (CCS).MethodsA literature search was performed within MEDLINE, EMBASE, and CENTRAL (1966‐11/2020) and reference lists of relevant studies. Studies were eligible for inclusion if they reported ECG abnormalities ≥2 years after cancer diagnosis in ≥50 CCS treated with anthracyclines, RT involving the heart region and/or mitoxantrone. Information about population, treatment, outcome, and risk factors were extracted and risk of bias was assessed.ResultsOf 934 identified publications, 10 studies were included. Outcome definitions, treatment regimens, follow‐up period, and risk of bias varied. These ECG abnormalities and prevalences were reported: major (5%‐23%) and minor (12%) abnormalities according to the Minnesota Code, rhythm abnormalities (0%‐12%), conduction abnormalities (0.3%‐7.1%), depolarization abnormalities (0%), and repolarization abnormalities (0%‐65%). The reported risk factors of ECG abnormalities (two studies) are male sex, anthracyclines, RT involving the heart region, and hypertension, although results were not univocal between studies and abnormalities.ConclusionsMultiple ECG abnormalities have been described in CCS ≥2 years from diagnosis, some of which can have important implications. Future research is needed to evaluate the exact long‐term incidence and risk factors, and to investigate their clinical relevance and relation with cardiac dysfunction or future cardiac events. This could improve cardiac surveillance for CCS.
Prediction of influences of size and locations of delamination on dynamic characteristics of laminated composite plate using particle swarm optimization and artificial neural network
Authors: K Arun Kumar , Arumugam Ananda Babu , D Mallikarjuna Reddy , P Edwin Sudhagar , P Anbumani , Kassa Mesfin Kebede , Agarwal Daksh 
Published: April 2022

AbstractIn laminated composite structures, delamination is one of the most common defects. The delamination affects the vibration characteristics of laminates, and thus these indicators can be used to detect the potentially catastrophic failures and measures the health characteristics of laminates. In this study, particle swarm optimization (PSO) and artificial neural network (ANN) are used to optimize and predict the influences of location and size of delamination on the dynamic behavior of composite plates. The classical laminated plate theory adopted principle equation based on the dynamic characteristics of composite laminate has expressed through the finite element method. The delamination behavior of laminate composite plate is modeled by considering delamination at several interfaces with variable sizes and locations. PSO methodology is recommended to optimize the decrease in natural frequency due to the delamination with varying weight fractions under completely clamped edge boundary conditions. Further, an ANN algorithm is proposed for predicting the dynamic responses of the composite plate by considering unknown ranges of parameters such as weight fraction, ply configuration, and different delamination locations.
The assessment of creativity for people with autism spectrum disorder
Authors: Maykel Cheryl , Kaufman James C. 
Published: April 2022

AbstractThe term “creativity” can conjure various ideas and meanings. It's no surprise that methods for measuring such a concept vary widely and are not without controversy. This is particularly true among people with autism spectrum disorder (ASD), who are a unique yet incredibly diverse group of individuals. This article provides an overview of the assessment of creativity among individuals with ASD. Findings among studies that have sought to determine whether individuals with ASD are more or less creative than their neurotypical peers are mixed, yet the authors propose that intentional development of creativity in all youth, including those with ASD, can be beneficial.
Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide
Authors: Testai Lara , Pagnotta Eleonora , Piragine Eugenia , Flori Lorenzo , Citi Valentina , Martelli Alma , Mannelli Lorenzo Di Cesare , Ghelardini Carla , Matteo Roberto , Suriano Serafino , Troccoli Antonio , Pecchioni Nicola , Calderone Vincenzo 
Published: April 2022

AbstractEruca sativa Mill. is an edible plant belonging to the Brassicaceae botanical family with a long story as a medicinal material, mainly linked to the presence of glucoerucin. One of the main products of this glucosinolate is erucin, a biologicallly active isothiocyanate recently recognized as a hydrogen sulfide (H2S) donor. In this work, an Eruca sativa extract has been obtained from a defatted seed meal (DSM), achieving a powder rich in thiofunctionalized glucosinolates, glucoerucin, and glucoraphanin, accounting for 95% and 5% of the total glucosinolate content (17% on a dry weight basis), associated with 13 identified phenolic acids and flavonoids accounting for 2.5%. In a cell‐free model, Eruca sativa DSM extract slowly released H2S. Moreover, this extract promoted significant hypotensive effects in hypertensive rats, and evoked dose‐dependent cardioprotection in in vivo model of acute myocardial infarct, obtained through a reversible coronary occlusion. This latter effect was sensitive to blockers of mitochondrial KATP and Kv7.4 potassium channels, suggesting a potential role of these mitochondrial channels in the protective effects of Eruca sativa DSM extract. Accordingly, Eruca sativa DSM extract reduced calcium uptake and apoptotic cell death in isolated cardiac mitochondria. Taken together, these results demonstrate that Eruca sativa DSM extract is endowed with an interesting nutraceutical profile on the cardiovascular system due to, at least in part, its H2S releasing properties. These results pave the way for future investigations on active metabolites.
Relational uncertainty, interdependence and psychological distress during COVID‐19: A longitudinal study
Authors: Estlein Roi , Segel‐Karpas Dikla , Elran‐Barak Roni 
Published: April 2022

AbstractDrawing on the relational turbulence theory, this study explored the associations of self, partner and relationship uncertainty, and partner interference and facilitation with psychological distress symptoms during the COVID‐19 stay‐at‐home orders. A longitudinal study of 313 individuals was conducted in Israel at three time points, spanning from the first lockdown (April 2020) and through the alleviation of the severe restrictions (June 2020). Multilevel modelling indicated divergent associations between the different sources of relational uncertainty and interdependence and somatization, depression and anxiety. Further analyses pointed to divergent findings regarding how change in self, partner and relationship uncertainty predicted change in somatization, depression and anxiety over the course of the study, depending on whether the three sources of relational uncertainty were analysed separately or simultaneously in the same model. Change in interference from a partner did not predict changes in psychological distress. Theoretical and practical implications of the findings are discussed.
Drawing at the Nanoscale through Macroscopic Movement
Authors: Xu Chao , Liu Hong , Yang Shikuan 
Published: April 2022

AbstractNanopatterns are important for applications in various nanodevice fields. Existing nanopatterning techniques mainly directly manufacture the nanopatterns through various lithographic methods, which usually are laborious, time‐consuming, and need expensive equipment. Here, an extremely simple drawing at the nanoscale (DAN) concept to indirectly fabricate rational nanopatterns through controlling the macroscopic movement of the substrate , is demonstrated. The structure of the nanopatterns is completely determined by and can be shrunk by millions of times from the moving track of the substrate. Multiple surface nanopatterns of different materials with accurately tailorable relative positions can be simply stacked together by moving the substrate by macroscopic distances during different DAN processes. In combination with sophisticated lithographic methods, the DAN method is anticipated to enable substantial advances in nanofabrication.
Retrospective analysis of 302 ovine dystocia cases presented to a veterinary hospital with particular attention to uterine torsion
Authors: Balasopoulou Viktoria , Zablotski Yury , Zerbe Holm , Voigt Katja 
Published: April 2022

AbstractBackgroundDystocia is common in sheep, and foetal causes are predominant. Among maternal causes, insufficient cervical dilatation is the most frequent problem. Uterine torsion has been considered rare by many authors.ObjectivesThis study was conducted to investigate causes of dystocia in sheep presented for veterinary attention, and particular focus was set on the description of uterine torsion and analysis of potentially predisposing factors for this condition.MethodsClinical records of 302 sheep treated for dystocia were evaluated retrospectively. Known and proposed risk factors for uterine torsion in cattle were analysed regarding their potential importance in sheep. These included lamb birth weights, ewe age, parity, season, nutrition, breed type, litter size and husbandry.ResultsMaternal causes of dystocia accounted for 67.2% (203/302) of the presented cases. Of these, insufficient cervical dilatation (121/203, 59.6%) was the most frequent diagnosis. Another substantial proportion of maternal causes (60/203, 29.6%) was identified as uterine torsion. Husbandry, breed type and litter size showed significance in univariate analyses, with lower odds for meat breeds (OR 0.22; p < 0.001), twin‐ (OR 0.49; p = 0.020) or multiple‐bearing ewes (OR 0.19; p = 0.013) and higher odds for fully housed animals (OR 17.87; p < 0.001). Year‐round housing was identified as the most influential factor in a subsequent multivariate analysis.ConclusionsUterine torsion was identified as a relevant cause of dystocia in our case load. The condition is likely to be underdiagnosed in sheep, and increased farmer and veterinary awareness is necessary to ensure adequate treatment of affected animals and to prevent unnecessary suffering.
Beaver: The North American freshwater climate action plan
Authors: Jordan Chris E. , Fairfax Emily 
Published: April 2022

AbstractRivers and streams, when fully connected to their floodplains, are naturally resilient systems that are increasingly part of the conversation on nature‐based climate solutions. Reconnecting waterways to their floodplains improves water quality and quantity, supports biodiversity and sensitive species conservation, increases flood, drought and fire resiliency, and bolsters carbon sequestration. But, while the importance of river restoration is clear, beaver‐based restoration—for example, strategic coexistence, relocation, and mimicry—remains an underutilized strategy despite ample data demonstrating its efficacy. Climate‐driven disturbances are actively pushing streams into increasingly degraded states, and the window of opportunity for restoration will not stay open forever. Therefore, now is the perfect time to apply the science of beaver‐based low‐tech process‐based stream restoration to support building climate resilience across the landscape. Not every stream will be a good candidate for beaver‐based restoration, but we have the tools to know which ones are. Let us use them.This article is categorized under:Science of Water > Hydrological ProcessesWater and Life > Nature of Freshwater EcosystemsWater and Life > Conservation, Management, and Awareness
Assessment of malignancy and PSMA expression of uncertain bone foci in [18F]PSMA-1007 PET/CT for prostate cancer—a single-centre experience of PET-guided biopsies
Authors: Vollnberg Bernd , Alberts Ian , Genitsch Vera , Rominger Axel , Afshar-Oromieh Ali 
Published: April 2022

Abstract
Purpose
Uncertain focal bone uptake (UBU) with intensive radiopharmaceutical avidity are frequently observed in patients undergoing [18F]PSMA-1007 PET/CT for the detection of prostate cancer (PC). Such foci can pose diagnostic conundrums and risk incorrect staging. The aim of this short communication is to share the results of PET-guided biopsies of such foci.

Methods
A retrospective analysis revealed 10 patients who were referred to our department for PET-guided biopsy of UBU visible in a previous [18F]PSMA-1007 PET/CT. [18F]-PSMA-1007 PET-guided biopsy was conducted for 11 PSMA-avid bone foci in these 10 patients. The biopsy materials were analysed for tissue typing, and immunohistochemistry (IHC) was performed for prostate-specific-membrane-antigen (PSMA) expression. The scans were analysed by two experienced physicians in a consensus read for clinical characteristics and radiopharmaceutical uptake of foci.

Results
One out of 11 (9.1%) of the foci biopsied was confirmed as bone metastasis of PC with intense PSMA-expression, while 10/11 (90.9%) foci were revealed to be unremarkable bone tissue without evidence of PSMA expression at IHC. Amongst all bone foci assessed by biopsy, eight were visually classified as being at high risk of malignancy in the PET/CT (SUVmean 12.0 ± 8.1; SUVmax 18.8 ± 13.1), three as equivocal (SUVmean 4.6 ± 2.1; SUVmax 7.2 ± 3.0) and zero as low risk. No UBU had any CT correlate.

Conclusions
This cohort biopsy revealed that a small but relevant number of UBU are true metastases. For those confirmed as benign, no PSMA expression at IHC was observed, suggesting a non-PSMA mediated cause for intensive [18F]PSMA-1007 uptake of which the reason remains unclear. Readers must interpret such foci with caution in order to reduce the risk of erroneous staging and subsequent treatment. PET-guided biopsy, particularly in the absence of morphological changes in the CT, can be a useful method to clarify such foci.