bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Cuán “global” es la formación en literatura? El caso de Argentina
Authors: Saferstein Ezequiel , Levitt Peggy 
Published: June 2022

ResumenDesde formas y latitudes distintas, existen llamamientos a la globalización de la educación superior. Pero, ¿qué es lo que realmente se pide? Este artículo examina los programas de enseñanza de teoría y crítica literaria de Argentina, un país históricamente atravesado por el pensamiento europeo, con una sólida producción académica. Encontramos que los programas priorizan la producción nacional y una selección de obras internacionales, con inclinación hacia el pensamiento francés. Estos resultados se explican por la ecología institucional y la distribución intelectual del trabajo entre las instituciones más antiguas y prestigiosas que se centran en el ámbito nacional y las más recientes, con mayor inclinación internacional. También se explican por el peso de la traducción, que permite mayor acceso a materiales. Además, encontramos bibliografía realizada por fuera de América Latina, Europa y Estados Unidos, de académicos globalizados que dejaron sus países de origen para estudiar en Europa y Estados Unidos.
Utopía y política en el pensamiento científico latinoamericano de la segunda mitad del siglo XX: La contribución de Oscar Varsavsky
Authors: Castro Martinez Christian J. 
Published: June 2022

ResumenEste artículo explora el concepto de “utopías realistas” del químico argentino Oscar Varsavsky. Mientras la mayoría de las interpretaciones del trabajo de Varsavsky recuperan sus aportaciones a los estudios de ciencia y tecnología en América Latina, aquí se argumenta que su idea de “estilo científico” forma parte de un marco teórico más amplio. De este modo, la discusión se enfoca en el uso que el autor dio a las ciencias nuevas y al enfoque de sistemas para adaptarlos al proyecto liberador de las utopías realizables. Inicialmente se problematiza el eclecticismo teórico de Varsavsky y su redefinición ideológica ante el fenómeno intelectual argentino de los años sesenta y setenta; después se discute su idea de utopías realizables e ingeniería utópica articulada a la noción de poder y cambio social; finalmente, se exponen los conceptos de racionalidad pueblocéntrica y estilos sociales.
The Influence of Pinochet on the Chilean Miracle
Authors: Escalante Edwar E. 
Published: June 2022

AbstractThis article analyzes the impact of Augusto Pinochet’s autocracy on the Chilean economy. The study compares outcomes under Pinochet’s leadership with those in a synthetic counterfactual made of a weighted average of countries with similar characteristics. It finds that, relative to the control, Chilean income per capita greatly underperformed for at least the first fifteen years after Pinochet’s coup. The results are robust to extending the pool of donor countries and expanding the pretreatment period by switching data sets to capture potential heterogeneity of effects. The evidence suggests that Chile’s remarkable economic growth during the period 1985–1997 did not depend on Pinochet’s autocracy. These results further bring into question the effectiveness of the regime to enhance economic growth and the narrative of the Chilean miracle.
Salinity levels affect the lysine nutrient requirements and nutrient metabolism of juvenile genetically improved farmed tilapia (Oreochromis niloticus)
Authors: Shao Ming , Xu Hao , Ge Xianping , Zhu Jian , Huang Dongyu , Ren Mingchun , Liang Hualiang 
Published: June 2022

AbstractThis 62-d research aimed to evaluate the effects of dietary lysine levels (DLL) and salinity on growth performance and nutrition metabolism of genetically improved farmed tilapia (GIFT) juveniles (Oreochromis niloticus). Six diets with lysine supplementation (1·34, 1·70, 2·03, 2·41, 2·72 and 3·04 % of DM) were formulated under different cultured salinities in a two-factorial design. The results indicated that supplemental lysine improved the specific growth rate (SGR) and weight gain (WG) and decreased the feed conversion ratio (FCR). Meanwhile, the fish had higher SGR and WG and lower FCR at 8 ‰ salinity. Except for moisture, the whole-body protein, lipid and ash content of GIFT were increased by 8 ‰ salinity, which showed that DLL (1·34 %) increased the whole-body fat content and DLL (2·41 %) increased whole-body protein content. Appropriate DLL up-regulated mRNA levels of protein metabolism-related genes such as target of rapamycin, 4EBP-1 and S6 kinase 1. However, 0 ‰ salinity reduced these protein metabolism-related genes mRNA levels, while proper DLL could improve glycolysis and gluconeogenesis mRNA levels but decrease lipogenesis-related genes mRNA levels in liver. 0 ‰ salinity improved GLUT2, glucokinase and G6 Pase mRNA levels; however, sterol regulatory element-binding protein 1 and fatty acid synthase mRNA levels were higher at 8 ‰ salinity. Moreover, 8 ‰ salinity also increased plasma total protein and cholesterol levels and decreased glucose levels. These results indicated that the recommended range of lysine requirement under different salinity was 2·03–2·20 % (0 ‰) and 2·20–2·41 % (8 ‰) and 8 ‰ salinity resulted in higher lysine requirements due to changes in the related nutrient metabolism, which might provide useful information for designing more effective feed formulations for GIFT cultured in different salinity environment.
Doing ‘coolie’ work in a ‘gentlemanly’ way: Gender and caste on the famine public works in colonial North India
Authors: Jha Madhavi 
Published: June 2022

AbstractThe second half of the nineteenth century was marked by regular famines and scarcities in India, and famine public works were one of the chief ways for the colonial state to provide relief. Famine public works involved labourers, including a large number of women, working in the construction of railways, roads, canals, and tanks in return for a subsistence wage. The present article contextualizes the practices of famine public works, especially the segregation of famine public works into large departmental and village works, within the intersecting processes of labour, caste, and gender. Drawing on evidence from North Western Provinces and Punjab, the article makes two arguments. First, it shows that segregation in famine works was driven by a shared understanding of the dominant castes and colonial state regarding labour, property, and caste which ensured that village works were reserved for dominant castes. A relational definition of labour was central to the construction of caste respectability on famine works. Second, by comparing the sex ratio of labourers in the two kinds of famine works, the article argues that women's labour was not merely a marker of caste, but constitutive of it.
Gender differences in the mechanism of involuntary retirement affecting loneliness through vulnerability and coping resources
Authors: Shin Oejin , Park Sojung , Lee Hyunjoo , Kang Ji Young 
Published: June 2022

AbstractInvoluntary retirement is associated with diminished mental health. However, little is known about the mechanism that connects involuntary retirees' coping resources to their loneliness. Gender patterns in the mechanism of involuntary retirement are also unclear. This study examines gender differences in the link between involuntary retirement and loneliness through secondary stressors (material and physical vulnerability) and coping resources (social support and self-efficacy). Two-step structural equation modelling was used to examine the effects of several mediators. For both men and women, involuntary retirement was associated with increased loneliness in terms of physical vulnerability and social efficacy. We found the female involuntary retirees are facing loneliness with multiple mediating factors. The layers of experiencing loneliness among female retirees are (a) directly from involuntary retirement; (b) indirectly from involuntary retirement and secondary stressors (material vulnerability and physical vulnerability); and (c) indirectly from involuntary retirement, secondary stressors (material vulnerability and physical vulnerability) and coping resources. The specific gender differences in the complex mechanism leading to later-year loneliness among the retirees may inform the interventions and policies that mitigate the disadvantages among involuntarily retired older adults in the United States of America.
Cardiac MRI for Fontan candidates after intrapulmonary-artery septation
Authors: Ishidou Motonori , Sato Keisuke , Sakamoto Kisaburo 
Published: June 2022

AbstractIntrapulmonary-artery septoplasty may be effective for establishing two-lung Fontan circulation in patients with unilateral pulmonary circulation. However, evaluation of the function of each lung by conventional modalities can be challenging in these patients due to differing sources of blood flow to the left and right lungs following intrapulmonary-artery septation. Herein, we report a case in which two-lung Fontan circulation was successfully achieved after using cardiac MRI along with conventional modalities to evaluate pulmonary circulation.
GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer
Authors: Kumegawa Kohei , Takahashi Yoko , Saeki Sumito , Yang Liying , Nakadai Tomoyoshi , Osako Tomo , Mori Seiichi , Noda Tetsuo , Ohno Shinji , Ueno Takayuki , Maruyama Reo 
Published: June 2022

AbstractIn breast cancer patients, tumor heterogeneity is associated with prognosis and therapeutic response; however, the epigenetic diversity that exists in primary tumors remains unknown. Using a single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq), we obtained the chromatin accessibility profiles of 12,452 cells from 16 breast cancer patients including 11 luminal, 1 luminal-HER2, 1 HER2+, and 3 triple-negative subtypes. Via this profiling process, tumors were classified into cancer cells and the tumor microenvironment, highlighting the heterogeneity of disease-related pathways including estrogen receptor (ER) signaling. Furthermore, the coexistence of cancer cell clusters with different ER binding motif enrichments was identified in a single ER+ tumor. In a cluster with reduced ER motif enrichment, we identified GRHL2, a transcription factor, as the most enriched motif, and it cooperated with FOXA1 to initiate endocrine resistance. Coaccessibility analysis revealed that GRHL2 binding elements potentially regulate genes associated with endocrine resistance, metastasis, and poor prognosis in patients that received hormonal therapy. Overall, our study suggests that epigenetic heterogeneity could lead to endocrine resistance and poor prognosis in breast cancer patients and it offers a large-scale resource for further cancer research.
VitalDB, a high-fidelity multi-parameter vital signs database in surgical patients
Authors: Lee Hyung-Chul , Park Yoonsang , Yoon Soo Bin , Yang Seong Mi , Park Dongnyeok , Jung Chul-Woo 
Published: June 2022

AbstractIn modern anesthesia, multiple medical devices are used simultaneously to comprehensively monitor real-time vital signs to optimize patient care and improve surgical outcomes. However, interpreting the dynamic changes of time-series biosignals and their correlations is a difficult task even for experienced anesthesiologists. Recent advanced machine learning technologies have shown promising results in biosignal analysis, however, research and development in this area is relatively slow due to the lack of biosignal datasets for machine learning. The VitalDB (Vital Signs DataBase) is an open dataset created specifically to facilitate machine learning studies related to monitoring vital signs in surgical patients. This dataset contains high-resolution multi-parameter data from 6,388 cases, including 486,451 waveform and numeric data tracks of 196 intraoperative monitoring parameters, 73 perioperative clinical parameters, and 34 time-series laboratory result parameters. All data is stored in the public cloud after anonymization. The dataset can be freely accessed and analysed using application programming interfaces and Python library. The VitalDB public dataset is expected to be a valuable resource for biosignal research and development.
Assessment of liver cirrhosis severity with extracellular volume fraction MRI
Authors: Mesropyan Narine , Kupczyk Patrick A. , Dold Leona , Praktiknjo Michael , Chang Johannes , Isaak Alexander , Endler Christoph , Kravchenko Dmitrij , Bischoff Leon M. , Sprinkart Alois M. , Pieper Claus C. , Kuetting Daniel , Jansen Christian , Attenberger Ulrike I. , Luetkens Julian A. 
Published: June 2022

AbstractWe aimed to investigate the diagnostic utility of MRI extracellular volume fraction (ECV) for the assessment of liver cirrhosis severity as defined by Child–Pugh class. In this retrospective study, 90 patients (68 cirrhotic patients and 22 controls), who underwent multiparametric liver MRI, were identified. Hepatic T1 relaxation times and ECV were assessed. Clinical scores of liver disease severity were calculated. One-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test, Spearman’s correlation coefficient, and receiver operating characteristic (ROC) analysis were used for statistical analysis. In cirrhotic patients, hepatic native T1 increased depending on Child–Pugh class (620.5 ± 78.9 ms (Child A) vs. 666.6 ± 73.4 ms (Child B) vs. 828.4 ± 91.2 ms (Child C), P < 0.001). ECV was higher in cirrhotic patients compared to the controls (40.1 ± 11.9% vs. 25.9 ± 4.5%, P < 0.001) and increased depending of Child–Pugh class (33.3 ± 6.0% (Child A) vs. 39.6 ± 4.9% (Child B) vs. 52.8 ± 1.2% (Child C), P < 0.001). ECV correlated with Child–Pugh score (r = 0.64, P < 0.001). ECV allowed differentiating between Child–Pugh classes A and B, and B and C with an AUC of 0.785 and 0.944 (P < 0.001, respectively). The diagnostic performance of ECV for differentiating between Child–Pugh classes A and B, and B and C was higher compared to hepatic native T1 (AUC: 0.651 and 0.910) and MELD score (AUC: 0.740 and 0.795) (P < 0.05, respectively). MRI-derived ECV correlated with Child–Pugh score and had a high diagnostic performance for the discrimination of different Child–Pugh classes. ECV might become a valuable non-invasive biomarker for the assessment of liver cirrhosis severity.
Effect of Cattaneo-Christov approximation for viscoelastic fluid with carbon nanotubes on flow and heat transfer
Authors: Mahabaleshwar U. S. , Sneha K. N. , Hatami M. 
Published: June 2022

AbstractThe current work studies the motion of viscoelastic liquid saturated with carbon nanotubes over a stretching surface in a Darcy porous medium analytically below an influence of Cattaneo-Christov heat flux. The carbon nanotubes (CNTs) act as nanoparticles which are then appended into the base fluid. Water and kerosene are used as a base fluid with two types of CNTs, namely, Single-wall carbon nanotubes and Multiwall carbon nanotubes. Carbon nanotubes possess a wide range of industrial and biomedical applications including energy production, nuclear reactor cooling, and galaxy cooling applications because they can expand the thermal and mechanical properties of base things. As a result, the carbon nanotubes used in the mentioned fields are being investigated for their potential in heat transfer applications. Governing equations formulated using the Partial differential equations have converted to Ordinary differential equations exhausting the appropriate comparison transformation process. An influence of some relevant constraints on velocity and temperature is evaluated in details. The Cattaneo-Christov heat transfer model is utilized to investigate the heat transfer individualities with varying thermal conductivity consuming the attributes of the Appell hypergeometric function. The impacts of the emerging parameters on the profiles are depicted through graphical representations and analytically constructed tables. Considering its usefulness in modulating temperature distribution in different industrial application, including solar collector design, electronic cooling, building ventilation, etc. According to our findings, the temperature profile exhibits an enhancement with the thermal radiation parameter and the viscous-elastic fluids. In addition, when compared to the classical Fourier's law of heat conduction, the temperature profile and thermal boundary layer thickness for the Cattaneo-Christov heat flux model are lower.
Glycemic control and its associated factors in type 2 diabetes patients at Felege Hiwot and Debre Markos Referral Hospitals
Authors: Shita Nigusie Gashaye , Iyasu Ashagrie Sharew 
Published: June 2022

AbstractPoor glycemic control is a main public health problem among type 2 diabetes mellitus (T2DM) patients and a significant cause of the development of diabetic complications. This study aimed to assess the glycemic control status and its associated factors among type 2 diabetes patients in Felege-Hiwot and Debre Markos Referral Hospitals. A retrospective cohort study was conducted at Felege-Hiwot and Debre Markos Referral Hospitals from December 2014 to December 2015. We have reviewed the chart of these patients until January 2020. Type 2 diabetic patients on follow-up at Felege-Hiwot and Debre Markos Referral Hospitals who fulfilled the inclusion criteria of the study were included. The primary outcome was the level of blood glucose during the study period.Good glycemic controlwas defined as patients whose average fasting blood glucose measurement for three consecutive visits was between 70 and 130 mg/dL. A generalized linear mixed autoregressive order one model was used to identify the determinants of glycemic control. A total of 191 patients with 1740 observations were included in the study. The overall prevalence of good glycemic control was 58.4% (95% CI: 57.159.7%). The factors associated with good glycemic control at 95% confidence level adjusted odds ratio were being residing in rural(CI: 0.454, 0.614), negative proteinuria (CI: 1.211, 1.546), diastolic blood pressure < 90 (CI: 1.101, 1.522), systolic blood pressure < 140 (CI: 1.352, 1.895), serum creatinine (CI: 0.415, 0.660), duration per visit (CI: 0.913, 0.987), duration since diagnosis (CI: 0.985, 0.998), weight ≥ 78 kg (CI: 0.603, 0.881). Age 38–50, 51–59 and 60–66 years (CI: 1.267, 1.776), (CI: 1.057, 1.476) and (CI: 1.004, 1.403), respectively. The overall prevalence of poor glycemic control was high at Debre Markos and Felege Hiwot Referral Hospital. Living in a rural area, older age (≥ 67 years), positive proteinuria, higher weight (≥ 78 kg), higher serum creatinine levels, higher duration per visit, higher time duration of T2DM since diagnosis, and developing hypertension (SBP ≥ 140, DBP ≥ 90) were the predictors of lower good glycemic control achievements of T2DM patients. In response to this finding, an aggressive intervention that targets improving glycemic control is required.
Bioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn.
Authors: Fagbemi Kehinde Oluwakemi , Aina Daniel Ayandiran , Adeoye-Isijola Morenike Olutunmbi , Naidoo Kubendran Kista , Coopoosamy Roger Murugas , Olajuyigbe Olufunmiso Olusola 
Published: June 2022

AbstractTamarindus indica is one of the tropical medicinal plants that has been attributed curative potential of numerous diseases by many rural dwellers. This study was designed to evaluate the antioxidant, antibacterial activities and also to determine the various chemical constituents responsible for its pharmacological activities. The methanol extract of Tamarindus indica fruit pulp was analyzed by Gas Chromatography/Mass Spectrometer to determine the volatile compounds present. The antioxidant activities were performed using DPPH and FRAP method and the antibacterial activity was tested against some common pathogens by macro broth dilution method. The GCMS analysis shows the presence of 37 compounds, out of which 14 had their peak area percentages ≥ 1% and only two compounds had no reported pharmacological activities. Most of the bioactive compounds including 5-Hydroxymethylfurfural (31.06%)-3-O-Methyl-d-glucose (16.31%), 1,6-anhydro-β-D-Glucopyranose (9.95%), 5-methyl-Furancarboxaldehyde (3.2%), Triethylenediamine (1.17%), 1-(2-furanyl)-1-Propcanone (2.18%), Methyl 2-furoate (3.14%), Levoglucosenone (3.21%), methyl ester-Hepta-2,4-dienoic acid, (8.85%), 2,3-dihydro-3,5-dihydrox-4H-Pyran-4-one (3.4%), O-α-D-glucopyranosyl-(1.fwdarw.3)-β-D-fructofuranosyl-α-D-Glucopyranoside (2.18%), n-Hexadecanoic acid (1.38%), 2-Heptanol, acetate (1.29%), 5-[(5-methyl-2-fur-2-Furancarboxaldehyde (1.08%), 3-Methyl-2-furoic acid (1.05%) and cis-Vaccenic acid (2.85%)have been reported with different activities such as antibacterial, antifungal, antitubercular, anticancer, antioxidant and other prophylactic activities. The extract demonstrated inhibitory potential against all tested pathogen. However, Plesiomonas shigellosis ATCC 15903 and Bacillus pumillus ATCC 14884 are more sensitive with the MIC of 0.22 and 0.44 mg/ml respectively. The antioxidant activity was relatively low due to the low phenolic content of the extract. This shows that there is a strong correlation between antioxidant activities and phenolic content. GC–MS analysis revealed the presence of bioactive phytoconstituents with various biological activities and this justifies the rationale behind its usage as a curative therapy by many local dwellers.
Supercontinuum generation in a nonlinear ultra-silicon-rich nitride waveguide
Authors: Cao Yanmei , Sohn Byoung-Uk , Gao Hongwei , Xing Peng , Chen George F. R. , Ng Doris K. T. , Tan Dawn T. H. 
Published: June 2022

AbstractSupercontinuum generation is demonstrated in a 3-mm-long ultra-silicon-rich nitride (USRN) waveguide by launching 500 fs pulses centered at 1555 nm with a pulse energy of 17 pJ. The generated supercontinuum is experimentally characterized to possess a high spectral coherence, with an average |g12| exceeding 0.90 across the wavelength range of the coherence measurement (1260 nm to 1700 nm). Numerical simulations further indicate a high coherence over the full spectrum. The experimentally measured supercontinuum agrees well with the theoretical simulations based on the generalized nonlinear Schrödinger equation. The generated broadband spectra using 500 fs pulses possessing high spectral coherence provide a promising route for CMOS-compatible light sources for self-referencing applications, metrology, and imaging.