bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of periodontitis on levels of autoantibodies in rheumatoid arthritis patients: A systematic review
Authors: Eezammuddeen Nazurah Nik , Vaithilingam Rathna Devi , Hassan Norul Husna Mohammad 
Published: November 2022

AbstractBackground and objectivePeriodontitis (PD) is a dysbiotic disease of tooth‐supporting structures that has been associated with various systemic diseases including rheumatoid arthritis (RA). To date, evidence demonstrated increased prevalence of RA among PD patients and postulated PD to have a role in the development of autoantibodies in RA patients. Therefore, a systematic review was conducted to assess the available evidence to ascertain the effect of PD on levels of autoantibodies in the serum, saliva and gingival crevicular fluid (GCF) of RA patients.Material and methodsThe systematic review was conducted in compliance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement guidelines. Relevant literature was searched from PubMed, Web of Science, Scopus and Ebscohost databases from inception until 31 August 2020. The risk of bias in each study was determined based on the Newcastle–Ottawa Scale tool. Results from random‐effect meta‐analyses were presented as summary estimates of odds ratios (ORs) for seropositivity and standardised mean difference (SMD) of autoantibody levels with 95% confidence intervals. Sensitivity tests and meta‐regression were performed to assess the robustness of the results and potential cause of heterogeneity.ResultsThe electronic and manual searches gathered 932 articles. Following screening and full‐text assessment, a total of 29 studies were included in the analysis. Twenty‐eight published observational studies were included in the quantitative analysis in the form of random‐effect meta‐analysis which revealed that PD was associated with anti‐citrullinated proteins autoantibodies (ACPAs) and Rheumatoid Factor (RF) seropositive RA patients (OR for ACPA seropositivity: 1.82; 95% CI: 1.13–2.93) (OR for RF seropositivity: 1.53; 95% CI: 1.05–2.24). Also, RA patients with PD had increased serum levels of ACPA and RF. However, high heterogeneity among studies' results, partially ascribed to the unstandardised case definition of PD and laboratory testing of autoantibodies. Apart from ACPA and RF in serum, studies which reported on other RA‐related autoantibodies, as well as autoantibody levels in saliva and GCF were scarce.ConclusionRA patients with PD tend to have greater ACPA and RF levels in their serum when compared with the RA patients without PD supporting the plausible role of PD in the development of systemic autoimmunity in RA patients.
Combined transposition of internal obturator and superficial gluteal muscles for perineal hernia treatment in dogs: 17 cases (2017‐2020)
Authors: Carbonell Rosselló G. , Turner A. , Macias C. , Ramírez J. M. 
Published: November 2022

ObjectivesTo report the results of the combined transposition of the internal obturator muscle and superficial gluteal muscle for perineal hernia treatment in dogs.Materials and MethodsRetrospective case series of dogs treated with this technique from November 2017 to May 2020, including pre‐ and post‐operative clinical findings, outcome and complications.ResultsSeventeen dogs were included in the study. Twelve dogs were presented with unilateral perineal hernia and five dogs with bilateral perineal hernias. Mean duration of clinical signs before presentation was 9 months. All perineal hernias were successfully repaired using a transposition of the internal obturator muscle to cover the ventral aspect of the perineal hernia and the superficial gluteal muscle to cover the dorsal aspect of the hernia with minimal tension. All dogs regained normal defecation within 24 hours post‐surgery. Average follow‐up time was 16 months. No recurrence of clinical signs or rectal deviation was observed. Five dogs developed a superficial minor partial necrosis of the T‐shaped incision and two had surgical site infections.Clinical SignificancePerineal herniorrhaphy using a combined transposition of the internal obturator and the superficial gluteal muscles is feasible and offered excellent results in this cohort of dogs. It may be considered as a technique for repairing chronic and extensive unilateral and bilateral perineal hernias.
Demographic and histopathologic features of dogs with abnormally high concentrations of hepatic copper
Authors: Ullal Tarini Vedantham , Lakin Steven , Gallagher Brooke , Sbardellati Nick , Abdo Zaid , Twedt David C. 
Published: November 2022

AbstractBackgroundCopper associated hepatopathy (CAH) has become an important and prevalent disease since the 1990's, coincidental with changes in copper (Cu) content in commercial dog foods. Knowing the demographic and histopathologic features related to hepatic Cu concentrations might aid in diagnosing CAH in dogs.Hypothesis/ObjectivesThe primary aim was to identify demographic and histopathologic features associated with abnormally high hepatic Cu concentrations.AnimalsDogs that underwent liver histopathology and Cu quantification at a veterinary diagnostic laboratory between July 2010 and February 2020.MethodsData was retrospectively collected from an electronic database. A Gaussian multiple regression model on the log scale was used to evaluate associations between hepatic Cu and a set of demographic and histologic features selected with machine learning methods.ResultsOf 4559 cases meeting criteria, 50% had hepatic Cu > 400 and 19% had Cu > 1000 ppm (parts per million) dry weight (reference range 120‐400). Median hepatic Cu was 391 ppm, range 4.5 to 31500. Age was negatively associated (P < .02), but specific breeds (Doberman pinscher, Labrador retriever, and West Highland white terrier) were positively associated with abnormally high hepatic Cu (P < .001). Severity of inflammation (mild, moderate, and severe) and necrosis/apoptosis were associated with abnormally high hepatic Cu (P < .01).Conclusion and Clinical ImportanceAbnormally high hepatic Cu is prevalent in hepatic biopsies from dogs. Machine learning modeling showed that necroinflammation, not cholestasis or cirrhosis, on hepatic histopathology, is predictive of higher hepatic Cu and might be a reliable histologic predictor of CAH.
‘Just pretending’: Narratives of professional identity transitions in internal medicine
Authors: Kerins Joanne , Smith Samantha E. , Tallentire Victoria R. 
Published: November 2022

AbstractIntroductionHealth professional identity transitions involve a dynamic period of liminality prompting a time of considerable uncertainty and self‐doubt. For postgraduate trainees in the United Kingdom, the transition to medical registrar can be a significant deterrent to recruitment and retention. Narrative analysis offers insight into identity work during transitions with potential to inform strategies for developing professional identities. This study aimed to use narrative analysis to explore trainees' experiences and their sense of agency during the liminal phase of this transition.MethodsFollowing ethical approval, internal medicine (IM) trainees in their second year of IM training were interviewed. Transcripts were audio recorded, transcribed verbatim and analysed to identify narratives describing liminality during the transition to the role of medical registrar, including examples of rejecting and claiming identity grants. Narrative analysis, as described by Riessman and influenced by James Gee's units of discourse, was undertaken, with an agentive lens applied to the data.ResultsBetween January 2021 and February 2022, 19 IM trainees were interviewed. Given the in‐depth analysis, four narratives were purposively selected to present, including trainees rejecting and claiming the medical registrar role. Trainees tended to describe negative experiences, but those with a higher sense of agency demonstrated positive reflection and identity construction through narrative. There was often identity dissonance between how trainees defined their stage in the transition to medical registrar and how their narrative illustrated their identity work.ConclusionThis study exemplifies narrative analysis' linguistic and agentive lenses in exploring the experience of the liminal identity transitional period. The findings reflect the identity dissonance experienced by trainees during this time and sheds light on their sense of agency throughout. It heralds a need to acknowledge the significant liminality experienced during transitions throughout medical training and to empower a sense of agency to support identity work.
Generation of Pmel‐dependent conditional and inducible Cre‐driver mouse line for melanocytic‐targeted gene manipulation
Authors: Nasrin Morsheda , Ahmed Osama , Han Xujun , Nojebuzzaman Md , Abo‐Ahmed Ahmed I. , Yazawa Shigenobu , Osawa Masatake 
Published: November 2022

AbstractConditional and inducible gene targeting using Cre/loxP‐mediated recombination is a powerful reverse genetics approach used to study spatiotemporal gene functions in specified cell types. To enable temporal gene manipulation in the melanocyte lineage, we established a novel inducible Cre‐driver mouse line by targeting an all‐in‐one tetracycline/doxycycline (Dox)‐inducible Cre expression cassette into the Pmel locus (PmelP2A‐TetON3G‐TRE3G‐iCre), a gene locus preferentially expressed in pigment cells. By crossing these Cre‐driver mice with a strong Cre‐reporter mouse line, Gt(ROSA)26Sortm9(CAG‐tdTomato)Hze, we show the effectiveness of the PmelP2A‐TetON3G‐TRE3G‐iCre mouse line in facilitating Dox‐inducible Cre/loxP recombination in a wide variety of pigment cell lineages including hair follicle melanocytes and their stem cells. Furthermore, to demonstrate proof of concept, we ablated Notch signaling postnatally in the PmelP2A‐TetON3G‐TRE3G‐iCre mice. In agreement with the previously reported phenotype, induced ablation of Notch signaling in the melanocyte lineage resulted in premature hair graying, demonstrating the utility of the PmelP2A‐TetON3G‐TRE3G‐iCre allele. Therefore, the PmelP2A‐TetON3G‐TRE3G‐iCre mouse line is suitable for assessing gene functions in melanocytes using an in vivo inducible reverse genetics approach. Furthermore, we unexpectedly identified previously unrecognized PMEL‐expressing cells in non‐pigmentary organs in the mice, suggesting unanticipated functions of PMEL other than melanosome formation.
Multiple oral sinus tract and trismus leading to a surprising diagnosis of osteopetrosis: Case report
Authors: Pinheiro Tiago Novaes , Desideri Vieira Ana Julia , Salino Alessandra Valle , de Oliveira Aranha Ribeiro Eliane , Felipe do Vale Hugo , de Souza Leitão Rodrigo , Carlos Roman , Tavares Ângelo Cintra Luciano 
Published: November 2022

AbstractAimsWe report a rare case of late diagnosis of malignant osteopetrosis in a 36‐year‐old male patient due to multiple intraoral sinus tracts and trismus.Case ReportThe patient reported a history of facial scars that could not be attributed to the older external fistulas that were present and various complicated dental extractions since infancy. In addition, the patient had not been previously diagnosed with any other significant diseases other than blindness since infancy. Computed tomography revealed a marble‐like sclerotic pattern of all cranial bones, a thickened parietal bone, and a narrowing of the encephalic space and the optic canal. Further laboratory and imaging studies revealed complete sclerosed bone of the chest and pelvis, anemia, reticulocitosis, extramedular hematopoiesis, altered dehydrogenasis lactate, and acid phosphatasis. An interdisciplinary treatment was initiated with medical and dental care monitoring. The patient is still receiving attention after 4 years of follow‐up.ConclusionsThe outcome of this case represents the daily challenges faced by interdisciplinary care providers and reveals pearls and pitfalls that can serve as a reference for professional practice in such cases.
The distinction between provoked and unprovoked aggression in toddlerhood, and associations with empathy‐related processes
Authors: Peets Kätlin , Vecchio Tamara Del 
Published: November 2022

AbstractPhysical aggression in toddlerhood has received considerable attention in the past 20 years. The underlying theme has been that toddlers behave aggressively due to not yet being able to regulate their frustration. However, there is some evidence to suggest that early aggression can occur for other reasons. In this study, we tested the distinction between provoked and unprovoked aggression in toddlerhood, and examined whether different empathy‐related processes would show unique associations with each type of aggression. Participants were 200 mothers of children aged 15–21 months (Mage = 18.32 months, SD = 1.75) who completed measures of provoked and unprovoked aggression, and empathy‐related processes. We found that the two‐factor aggression model fit the data well. In addition, when controlling for the overlap between other‐oriented empathy and personal distress, other‐oriented empathy demonstrated a negative association with unprovoked aggression, and personal distress showed a positive link with provoked aggression. Our findings underscore the importance of studying early physical aggression in a more nuanced way to better understand different functions it may serve in toddlerhood.
The role of the Belt and Road Initiative: New opportunity for Chinese exporters?
Authors: Jiang Lingduo , Zhang Guofeng , Zhang Hang 
Published: November 2022

AbstractUsing Chinese Customs data for the 2007–2018 period, we investigate how Chinese exporters respond to the Belt and Road Initiative (BRI). Based on a difference‐in‐differences identification strategy, we find that the BRI causes a substantial increase in China's total exports to BRI countries at the HS‐8 digit product level, and this export‐promoting effect is due to a significant increase in export quantity. We also find that exports increase more to countries along the Maritime Silk Road than those along the Land Silk Road. Moreover, the BRI contributes to optimising the export structure by increasing the proportion of general exports, promoting intermediate exports, improving upstreamness of exports and cutting excess capacity through international market demand. Combined with the existing studies focusing on the impacts on bilateral or global trade, our study helps develop a complete picture of the BRI effects from the perspective of the sponsor country.
Slow cooling in the metamorphic cores of Grenvillian large metamorphic core complexes and the thermal signature of the Ottawan orogenic lid
Authors: Rivers* Toby , Volkert* Richard A. 
Published: November 2022

ABSTRACT
Prolonged slow cooling (average 1–3 °C/m.y.) of Ottawan phase granulite-facies gneisses (peak temperature ≥850 °C ca. 1090–1080 Ma) through the argon closure temperatures (TC) of hornblende ca. 980–920 Ma and biotite ca. 890–820 Ma in the western Grenville Province and in an inlier in the central Appalachians is well established, but its tectonic setting has not been systematically investigated. Here, the case is made that this slow cooling occurred in the suprasolidus cores of large metamorphic core complexes that were exhumed during mid-Ottawan (ca. 1050 Ma) extensional orogenic collapse. The ductile midcrustal metamorphic cores of the large metamorphic core complexes are overlain across gently dipping extensional detachments by a brittle-ductile cover composed of upper orogenic crust, parts of which preserve evidence of relict pre-Ottawan fabrics and peak prograde Ottawan temperatures of &lt;500 °C (TC of Ar in hornblende), collectively implying thermal, structural, and rheological decoupling across the detachments. Slow average rates of cooling of the orogenic midcrust for &gt;150 m.y. imply an anomalously hot upper mantle and mask short periods of more rapid cooling indicated by analyses of retrograde diffusional mineral zoning patterns. It is suggested that these slow average rates of cooling, coupled with slow average rates of exhumation of ≤0.1 km/m.y. modeled for one data set, were a result of decompression melting of rising asthenosphere and emplacement of voluminous mafic intrusions within or at the base of the crust, which reduced the buoyancy of the residual thinned lithosphere. This process is compatible with either delamination of subcontinental lithospheric mantle or slab rollback.
The high-strain extensional detachments of the large metamorphic core complexes are sites of amphibolite-facies retrogression, suggesting a feedback between ingress of hydrous fluid, which was likely derived from beneath the detachment during crystallization of migmatite, and strain. Extensional juxtaposition of the hot midcrust (T &gt;850 °C) and cooler cover (T &lt;500 °C) across the detachments led to conductive heating of the base of the cover, locally raising its temperature above 500 °C, as recorded by amphibolite-facies metamorphism and young cooling ages.
The slow cooling and exhumation of Grenvillian large metamorphic core complexes contrast with much faster rates in smaller metamorphic core complexes in other settings (e.g., North American Cordillera). The slow rates of these processes in large metamorphic core complexes are attributed to the prolonged high temperature and low viscosity of their metamorphic cores due to proximity of the asthenosphere, and to the intrusion of voluminous asthenospheric mafic magmas that both advected heat and reduced lithospheric buoyancy.
The commercial determinants of Indigenous health and well-being: a systematic scoping review
Authors: Crocetti Alessandro Connor , Cubillo (Larrakia) Beau , Lock (Ngiyampaa) Mark , Walker (Yorta Yorta) Troy , Hill (Torres Strait Islander) Karen , Mitchell (Mununjali) Fiona , Paradies (Wakaya) Yin , Backholer Kathryn , Browne Jennifer 
Published: November 2022

IntroductionHealth inequity within Indigenous populations is widespread and underpinned by colonialism, dispossession and oppression. Social and cultural determinants of Indigenous health and well-being are well described. Despite emerging literature on the commercial determinants of health, the health and well-being impacts of commercial activities for Indigenous populations is not well understood. We aimed to identify, map and synthesise the available evidence on the commercial determinants of Indigenous health and well-being.MethodsFive academic databases (MEDLINE Complete, Global Health APAPsycInfo, Environment Complete and Business Source Complete) and grey literature (Australian Indigenous HealthInfoNet, Google Scholar, Google) were systematically searched for articles describing commercial industry activities that may influence health and well-being for Indigenous peoples in high-income countries. Data were extracted by Indigenous and non-Indigenous researchers and narratively synthesised.Results56 articles from the USA, Canada, Australia, New Zealand, Norway and Sweden were included, 11 of which were editorials/commentaries. The activities of the extractive (mining), tobacco, food and beverage, pharmaceutical, alcohol and gambling industries were reported to impact Indigenous populations. Forty-six articles reported health-harming commercial practices, including exploitation of Indigenous land, marketing, lobbying and corporate social responsibility activities. Eight articles reported positive commercial industry activities that may reinforce cultural expression, cultural continuity and Indigenous self-determination. Few articles reported Indigenous involvement across the study design and implementation.ConclusionCommercial industry activities contribute to health and well-being outcomes of Indigenous populations. Actions to reduce the harmful impacts of commercial activities on Indigenous health and well-being and future empirical research on the commercial determinants of Indigenous health, should be Indigenous led or designed in collaboration with Indigenous peoples.
Physician-reported barriers to using evidence-based antibiotic prescription guidelines in primary care: protocol for a systematic review and synthesis of qualitative studies using the Theoretical Domains Framework
Authors: Bursey Krystal , Hall Amanda , Pike Andrea , Etchegary Holly , Aubrey-Bassler Kris , Patey Andrea M , Romme Kristen 
Published: November 2022

IntroductionOverprescription of antibiotics poses a significant threat to healthcare globally as it contributes to the issue of antibiotic resistance. While antibiotics should be predominately prescribed for bacterial infections, they are often inappropriately given for uncomplicated upper respiratory tract infections (URTIs) and related conditions, such as the common cold. This study will involve a qualitative systematic review of physician-reported barriers to using evidence-based antibiotic prescription guidelines in primary care settings and synthesise the findings using a theoretical basis.Methods and analysisWe will conduct a systematic review of qualitative studies that assess physicians’ reported barriers to following evidence-based antibiotic prescription guidelines in primary care settings for URTIs. We plan to search the following databases with no date or language restrictions: MEDLINE, Web of Science, CINAHL, Embase, the Cochrane Library and PsycInfo. Qualitative studies that explore the barriers and enablers to following antibiotic prescription guidelines for URTIs for primary care physicians will be included. We will analyse our findings using the Theoretical Domains Framework (TDF), which is a theoretically designed resource based on numerous behaviour change theories grouped into 14 domains. Using the TDF approach, we will be able to identify the determinants of our behaviour of interest (ie, following antibiotic prescription guidelines for URTIs) and categorise them into the 14 TDF domains. This will provide the necessary information to develop future evidence-based interventions that will target the identified issues and apply the most effective behaviour change techniques to affect change. This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines.Ethics and disseminationEthical approval is not required. Findings will be published in a peer-reviewed journal and presented at conferences.