bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘I am not a Gentleman academic’: Telling our truths of micro‐coercive control and gaslighting in Business Schools using ‘Faction’
Authors: Edwards Michaela , Mitchell Laura , Abe Catherine , Cooper Emily , Johansson Janet , Ridgway Maranda 
Published: October 2022

AbstractThis paper draws from our own experiences of sexism within Business Schools to bring attention to the effects of the operation of a highly masculinized, white, cis‐gendered, and patriarchal culture, whether enacted by men or women, and to how we come to be silenced within it. Our work reflects on intersectional issues of race, health (mental and physical), and care‐work, using faction built from six paired interviews to tell a truth we feel unable to tell individually. This piece highlights the real fear of repercussions that still persist for female academics, and uses the acts of collecting data and writing differently to offer the authors a safe space in which to resist both overt and structural sexism in Business Schools. It highlights the need to take seriously those subtleties of sexism that we are often expected to put up with, those difficult‐to‐name aspects of our working lives that leave us feeling it would be “silly” to complain and act as a form of micro‐coercive control over our lives. We operationalize our collective voice as a form of activism in the academy that is situated within our individual silences.
Refugee‐owned small businesses: A typology for blended value creation
Authors: Ranabahu Nadeera , De Vries Huibert P. , Basharati Zhiyan 
Published: October 2022

AbstractWhile it is clear that refugee‐owned small businesses generate economic value, what is less understood is small businesses' role in blended value generation for ethnic/co‐ethnic and local host communities. To explore this issue, we conducted interviews with 19 refugee business owners residing in New Zealand. Our findings concur with the extant literature that refugee‐owned businesses generate economic, social and cultural value in their adopted countries. However, these businesses can be differentiated by their value focus; that is, whether the business' sole focus is economic or a nuanced blend, where economic value is complemented by strong social and cultural outcomes. In addition, these businesses' blended value generation is concentrated in either ethnic/co‐ethnic or to local host communities. We use the findings to construct a typology of value generated by refugee‐owned businesses, based on two continuums: from economic value to blended value and from ethnic/co‐ethnic focus to local host focus.
Local application of a transcutaneous carbon dioxide paste prevents excessive scarring and promotes muscle regeneration in a bupivacaine‐induced rat model of muscle injury
Authors: Hirota Junya , Hasegawa Takumi , Inui Atsuyuki , Takeda Daisuke , Amano‐Iga Rika , Yatagai Nanae , Saito Izumi , Arimoto Satomi , Akashi Masaya 
Published: October 2022

AbstractIn postoperative patients with head and neck cancer, scar tissue formation may interfere with the healing process, resulting in incomplete functional recovery and a reduced quality of life. Percutaneous application of carbon dioxide (CO2) has been reported to improve hypoxia, stimulate angiogenesis, and promote fracture repair and muscle damage. However, gaseous CO2 cannot be applied to the head and neck regions. Previously, we developed a paste that holds non‐gaseous CO2 in a carrier and can be administered transdermally. Here, we investigated whether this paste could prevent excessive scarring and promote muscle regeneration using a bupivacaine‐induced rat model of muscle injury. Forty‐eight Sprague Dawley rats were randomly assigned to either a control group or a CO2 group. Both groups underwent surgery to induce muscle injury, but the control group received no treatment, whereas the CO2 group received the CO2 paste daily after surgery. Then, samples of the experimental sites were taken on days 3, 7, 14, and 21 post‐surgery to examine the following: (1) inflammatory (interleukin [IL]‐1β, IL‐6), and transforming growth factor (TGF)‐β and myogenic (MyoD and myogenin) gene expression by polymerase chain reaction, (2) muscle regeneration with haematoxylin and eosin staining, and (3) MyoD and myogenin protein expression using immunohistochemical staining. Rats in the CO2 group showed higher MyoD and myogenin expression and lower IL‐1β, IL‐6, and TGF‐β expression than the control rats. In addition, treated rats showed evidence of accelerated muscle regeneration. Our study demonstrated that the CO2 paste prevents excessive scarring and accelerates muscle regeneration. This action may be exerted through the induction of an artificial Bohr effect, which leads to the upregulation of MyoD and myogenin, and the downregulation of IL‐1β, IL‐6, and TGF‐β. The paste is inexpensive and non‐invasive. Thus, it may be the treatment of choice for patients with muscle damage.
Recovery from insulin dependence in immune checkpoint inhibitor‐associated diabetes mellitus: A case report
Authors: Okubo Marie , Hataya Yuji , Fujimoto Kanta , Iwakura Toshio , Matsuoka Naoki 
Published: October 2022

ABSTRACTImmune checkpoint inhibitor‐associated diabetes mellitus (ICI‐DM) is a rare immune‐related adverse event and is usually considered permanent. Here, we report the first case of a 54‐year‐old man with ICI‐DM who recovered from insulin dependence. He was diagnosed with lung cancer and started pembrolizumab therapy. After seven cycles, he developed ICI‐associated secondary adrenal insufficiency and started hydrocortisone supplementation. Subsequently, he complained of fatigue, and blood examinations showed hyperglycemia with ketosis. A glucagon challenge test indicated insulin dependence. He was diagnosed with ICI‐DM and insulin therapy was initiated. Pembrolizumab therapy was discontinued due to concomitant ICI‐associated hepatitis. Six months later, a glucagon challenge test result showed an improvement in insulin secretion, and insulin therapy was discontinued. The lung cancer lesions continued to shrink. Even if ICI‐DM develops, it might be possible to control the underlying cancer while avoiding lifelong insulin therapy through early discontinuation of ICI.
Improving the drying performance of parchment coffee due to the newly redesigned drying chamber
Authors: Duque‐Dussán Eduardo , Banout Jan 
Published: October 2022

AbstractThe Colombian coffee growers face many complications when using traditional open‐sun drying techniques such as post‐harvest process delays or incomplete grain dryness because of climate conditions. Therefore, local workshops began fabricating low‐capacity dryers simulating the industrial equipment working principles. One of the most commercialized units is a triple tray rectangular‐shaped dryer with a 31.25 kg capacity of dry parchment coffee per batch, providing the issue with an acceptable solution. However, it was redesigned into a circular shape holding a lower grain bed thickness and a vertical air inlet with a diffusive tray. Both units were simulated using the Thompson and the Michigan State University grain drying mathematical models to obtain their theoretical drying time. Then, a computational fluid dynamics simulation was conducted, attaining the unit's drying air behavior, the circular dryer exhibited notable drying times reduction and even air distribution, optimizing the dryer's performance, representing a benefit for the coffee‐growing farmers.Practical ApplicationsA cylindrical arranged coffee dryer with a vertical air inlet reduces the drying time of the grain, allowing a better rentability of the grower and improves the air distribution inside the equipment, meaning that the moisture removal will occur uniformly, safeguarding that the product's final moisture content meets the required conditions for safe storage.
Optimizing Escherichia coli O157:H7 inactivation in goat's milk by thermosonication
Authors: Bernardo Yago A. A. , do Rosario Denes K. A. , Mutz Yhan S. , Castro Vinícius S. , Conte‐Junior Carlos A. 
Published: October 2022

AbstractEscherichia coli O157:H7 (STEC) is one of the hazardous foodborne pathogens in milk. Although traditional preservation methods reduce contamination, they are time‐consuming or cause physicochemical changes. Therefore, we optimize STEC inactivation in goat's milk by thermosonication, an alternative to traditional treatments. Different times (1–35 min) and temperatures (45.9–74.1°C) were applied, using a Central Composite Rotatable Design (CCRD). Lipid oxidation was adopted as an optimization limiting factor. Mathematical models described STEC inactivation and lipid oxidation with high performance, considering the high R2adj (0.942 and 0.731), and low mean square error (0.065 and <0.0001) and lack‐of‐fit (0.133 and 0.183). Validation was verified by the accuracy (1.141 and 1.017) and bias (0.992 and 1.006) factors, and the relative error of prediction (0.910 and 1.000). Both variables affected STEC inactivation linearly, enhancing decontamination. Lipid oxidation was affected by time, increasing oxidation products formation. Optimization was achieved around 1–20 min/62–74°C, improving STEC inactivation (6.6 log CFU/ml) with minimal lipid oxidation (0.06 mg MDA/L). Therefore, thermosonication represents a promising technology facing to traditional methods, ensuring bacteriological safety and minimal alterations.Practical ApplicationsDespite traditional methods for milk decontamination still being considered effective, there are some reports on pasteurized milk and dairy products‐related outbreaks. High‐intensity ultrasound is an emerging non‐thermal technology recently explored as a pathogen reduction method, used individually or combined. However, due to cavitation mechanism and free radicals realizing, some oxidative alterations could occur during processing. The present research paper contributes to provide a better understanding on the combined application of ultrasound and heat (thermosonication) to inactivate Escherichia coli in caprine milk. The findings herein are promising to the industrial utilization of thermosonication to obtaining safety products with minimal oxidative changes.
The role of raw materials to achieve the Sustainable Development Goals: Tracing the risks and positive contributions of cobalt along the lithium‐ion battery supply chain
Authors: da Silva Lima Lígia , Cocquyt Louise , Mancini Lucia , Cadena Erasmo , Dewulf Jo 
Published: October 2022

AbstractGiven the fast‐growing demand for electric mobility, the European Union (EU) has invested in responsible sourcing of battery raw materials, but the sustainability of their value chains is not fully addressed. Life cycle sustainability assessment is a tool to identify social, economic, and environmental aspects of raw materials, but it is mostly used for negative impacts, whereas the supply and use of raw materials may also lead to benefits. The Sustainable Development Goals (SDGs) can help to determine how raw materials boost or hinder the achievement of a sustainable society. In this study, the SDGs were used as a reference to assess contributions and risks of cobalt supply for electric mobility in the EU and whether this technology supports the achievement of the SDGs. The risks were determined using eight indicators focused on social risks, but environmental aspects like water quality and usage, and greenhouse gas emissions were also considered. The literature and databases were consulted to identify which SDGs receive contributions or burdens. Global and European cobalt supply scenarios were defined, considering the most representative countries. Results indicate that, although some SDGs receive positive contributions, like SDG 8 (Decent work and economic growth) and SDG 13 (Climate action), most of the identified correlations are negative, especially for SDG 3 (Good health and well‐being) and SDG 16 (Peace, justice, and strong institutions). The European scenario has a low risk toward socio‐environmental issues in 53% of the assessed aspects, whereas the global scenario presents a high risk in 47% of them.
A hierarchical Bayesian regression model that reduces uncertainty in material demand predictions
Authors: Bhuwalka Karan , Choi Eunseo , Moore Elizabeth A. , Roth Richard , Kirchain Randolph E. , Olivetti Elsa A. 
Published: October 2022

AbstractPredictions of metal consumption are vital for criticality assessments and sustainability analyses. Although demand for a material varies strongly by region and end‐use sector, statistical models of demand typically predict demand using regression analyses at an aggregated global level (“fully pooled models”). “Un‐pooled” regression models that predict demand at a disaggregated country or regional level face challenges due to limited data availability and large uncertainty. In this paper, we propose a Bayesian hierarchical model that can simultaneously identify heterogeneous demand parameters (like price and income elasticities) for individual regions and sectors, as well as global parameters. We demonstrate the model's value by estimating income and price elasticity of copper demand in five sectors (Transportation, Electrical, Construction, Manufacturing, and Other) and five regions (North America, Europe, Japan, China, and Rest of World). To validate the benefits of the Bayesian approach, we compare the model to both a “fully pooled” and an “un‐pooled” model. The Bayesian model can predict global demand with similar uncertainty as a fully pooled regression model, while additionally capturing regional heterogeneity in income elasticity of demand. Compared to un‐pooled models that predict demand for individual countries and sectors separately, our model reduces the uncertainty of parameter estimates by more than 50%. The hierarchical Bayesian modeling approach we propose can be used for various commodities, improving material demand projections used to study the impact of policies on mining sector emissions and informing investment in critical material production.
Flow cytometry as an alternative method to evaluate genotoxicity of natural cosmetic actives
Authors: Ueoka Andreza R. , Sufi Bianca S. , Magalhães Wagner V. , Fernandes Liliam , Andreo‐Filho Newton , Leite‐Silva Vania R. , Lopes Patricia S. 
Published: October 2022

AbstractAlternative in vitro methods are important, as there is a call to ban the use of animals in cosmetics research.AimTo suggest the expansion of the use of in vitro safety techniques recommended by the OECD guidelines and to propose the use of the automation of the in vitro mammalian micronucleus test method by flow cytometry to assess the genotoxic potential ofCentella asiatica, Horse Chestnut, Witch Hazel, Blend, Ecoblend, and Caffeine extracts due to their widespread use in commercial products.MethodsFlow cytometer analysis was performed using the Accuri™ C6 equipment and analyzed using the FlowJo software. Cytotoxicity tests followed OECD 129 guidelines and Phototoxicity followed OECD/GD 432 guidelines.ResultsThe results showed that the cytotoxicity assay presented a decrease in cell viability when cells were exposed toCentella asiaticafrom a concentration of 5.0%, horse chestnut 2.5%, Witch hazel 2.5%, Blend 3.13%, and Caffeine 3%, while Ecoblend at the tested concentrations did not show cytotoxicity. In the phototoxicity test, the samples at the tested concentrations showed a PIF <2 being considered potentially non‐phototoxic. Finally, in the genotoxicity automated assay, samples were considered potentially non‐genotoxic.ConclusionIn vitro methods are of paramount importance for the development of pre‐clinical tests and the use of test automation helps to reduce the time for analysis and dissemination of results, being a determining factor for the prospect of new compounds.
Presence of pastoral fields in mountain landscapes influences prey consumption by European wildcats
Authors: Ruiz‐Villar H. , Urra F. , Jubete F. , Morales‐González A. , Adrados B. , Revilla E. , Rivilla J. C. , Román J. , Seijas J. , López‐Bao J. V. , Palomares F. 
Published: October 2022

AbstractTraditional agro‐pastoral practices are more beneficial for biodiversity than intensified agricultural systems. Promotion of the growth of natural herbaceous vegetation in pastoral fields can enhance rodent populations and consequently influence ecological aspects of carnivores with rodent‐based diets, like prey consumption in the European wildcat (Felis silvestris). In this article, we investigated the effects of pastoral field extent, season and prey abundance on wildcat consumption of several prey species in the Cantabrian Mountains (NW Spain). Prey consumption in areas with presence of pastoral fields (even in low proportions) was dominated by profitable field‐dwelling rodent species such as Arvicola monticola. Consumption of Arvicola was not correlated with its abundance and was higher during summer and autumn. Apodemus dominated the wildcat diet in areas with higher forest proportion and far from pastoral fields, particularly during spring. Our results suggest that varying habitat use and seasonal changes in prey accessibility may determine wildcat prey consumption in pastoral landscapes. Our results can contribute to highlight the potential benefits of traditional and sustainable pastoral activities for the conservation of the European wildcat across its distribution range.
Human poliovirus receptor contributes to biliary atresia pathogenesis by exacerbating natural‐killer‐cell‐mediated bile duct injury
Authors: Li Yuan , Li Tian‐Yu , Qi Qiao , Zhang Min‐Ting , Tong Ming‐Xin , Su Peng‐Jun , Zhang Zhi‐Bo 
Published: October 2022

AbstractBackground and AimsNatural killer (NK) cells play an important role in biliary atresia (BA) pathogenesis; human poliovirus receptor (PVR) is an important NK‐cell modulator. Here, we explored the role of PVR in BA pathogenesis.MethodsPoliovirus receptor expression and NK cell‐associated genes were detected in human BA samples and a rotavirus‐induced BA mouse model using quantitative PCR and immunofluorescence staining. Chemically modified small interfering RNA silenced PVR expression in the BA model, and its effects on the population and function of intrahepatic NK cells were investigated using flow cytometry (FCM). The effects of PVR overexpression and knockdown on proliferation, apoptosis and NK‐cell‐mediated lysis of cultured human cholangiocytes were analysed using FCM and cell viability assays. Serum PVR, high‐mobility group box 1 (HMGB1), and interleukin‐1beta (IL‐1beta) levels were measured in a cohort of 50 patients using ELISA.ResultsPoliovirus receptor expression was upregulated in the biliary epithelium of BA patients and BA model and was positively correlated with the population and activation of intrahepatic NK cells. Silencing of PVR expression impaired the cytotoxicity of NK cells, reduced inflammation and protected mice from rotavirus‐induced BA. Activation of the TLR3‐IRF3 signalling pathway induced PVR expression in cultured cholangiocytes. PVR overexpression promoted proliferation and inhibited the apoptosis of cholangiocytes but exacerbated NK cell‐mediated cholangiocyte lysis. Serum PVR levels were elevated in BA patients and were positively correlated with HMGB1 and IL‐1beta levels.ConclusionsPoliovirus receptor contributes to BA pathogenesis by regulating NK cell‐mediated bile duct injury; PVR has the value as a biomarker of BA.
Young magmatism and Si‐rich melts on Mars as documented in the enriched gabbroic shergottite NWA 6963
Authors: Lindner Miles , Hezel Dominik C. , Gerdes Axel , Marschall Horst R. , Brenker Frank E. 
Published: October 2022

AbstractEnriched shergottites contain interstitial Si‐rich mesostasis; however, it is unclear whether such mesostasis is formed by impact or magmatic processes. We use laser ablation multicollector inductively coupled plasma mass spectrometry U–Pb measurements of minerals within the interstitial Si‐rich mesostasis and of merrillite within the coarse‐grained groundmass of Martian‐enriched gabbroic shergottite Northwest Africa (NWA) 6963. The date derived of tranquillityite, Cl‐apatite, baddeleyite, and feldspar from the Si‐rich mesostasis is 172.4 ± 6.1 Ma, and the derived merrillite date is 178.3 ± 10.6 Ma. We conclude, based on textural observation, that merrillite is a late magmatic phase in NWA 6963, that it was not produced by shock, and that its U–Pb‐system was not reset by shock. The indistinguishable dates of the gabbroic merrillite and the minerals within the Si‐rich mesostasis in NWA 6963 indicate that the Si‐rich mesostasis represents a late‐stage differentiated melt produced in the final phase of the magmatic history of the gabbroic rock and not a shock melt. This can likely be transferred to similar Si‐rich mesostases in other enriched shergottites and opens the possibility for investigations of Si‐rich mesostasis in enriched shergottites to access their magmatic evolution. Our results also provide a crystallization age of 174 ± 6 Ma (weighted average) for NWA 6963.
Mid‐Term Outcomes of Cemented Stem and Subtrochanteric Shortening Derotational Osteotomy in Total Hip Arthroplasty for Crowe IV Developmental Dysplasia
Authors: Huang Zhe‐Yu , Ling Jing , Zeng Zhi‐Min , Di Zheng‐Lin , Zhang Jun‐Hui , Tao Kun 
Published: October 2022

ObjectivePerforming subtrochanteric osteotomy with cemented components in patients with Crowe IV developmental dysplasia of the hip (DDH) is technically challenging and not widely reported. This study aimed to evaluate the mid‐term outcomes of cemented stem total hip arthroplasty (THA) with subtrochanteric femoral shortening and transverse derotational osteotomy in patients with Crowe IV DDH.MethodsData collected from patients with Crowe IV DDH who underwent cemented stem THA with subtrochanteric femoral shortening and transverse derotational osteotomy between 2010 and 2018 were retrospectively evaluated. The cemented Lubinus SP II femoral component and the cementless CombiCup acetabular component were used together in all cases. These data, including Harris hip scores, limb length discrepancy (LLD), severity of limp, Trendelenburg test, bone union, length of the resected femur, limb lengthening, level of the osteotomy site, and length bridging the osteotomy site, as well as complications, were analyzed. A paired Student t‐test was used to analyze continuous variables, categorical data were compared using Fisher's exact probability test, and correlation analysis was performed using Spearman's rank correlation coefficient.ResultsAmong 14 included patients (10 females and four males), the mean age was 60.4 years (range, 47–73). The mean follow‐up period was 49.1 months, and no patient was lost to follow‐up. The mean Harris hip score improved from 40.7 to 87.7. The mean LLD decreased from 52 to 12.7 mm. The mean length of the excised femoral segment was 38.4 mm, and the mean length of limb lengthening was 27.1 mm. The mean distance between the osteotomy site and the lesser trochanter was 21.1 mm after surgery. The mean length of the femoral stem bridging the osteotomy site was 97.6 mm. Finally, the mean osteotomy union time was 10.6 months. No statistically significant correlation was found between the osteotomy union time and these factors. No neurological deficits were noted. Delayed union was observed in one patient, and postoperative dislocation was observed in two patients. Cement leakage into the osteotomy gap was observed in one patient, however, no revisions were required, and no signs of loosening or migration were observed.ConclusionsCemented stem THA combined with subtrochanteric femoral shortening and transverse derotational osteotomy is safe and effective in treating patients with Crowe IV DDH. Rather than leading to nonunion, cement leakage may negatively affect bone healing.