bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dam-induced changes in river flow dynamics revealed by RQA
Authors: Kędra Mariola 
Published: October 2022

AbstractThe impact of dam construction on the river environment has been widely studied from various perspectives (e.g. biochemical, hydrological, ecological, geomorphological). To obtain new information, recurrence quantification analysis (RQA) is used to analyze the dynamics of mountain river flow and its changes caused by the construction of dam reservoirs with different parameters and functions. The analysis focuses on daily river flow for time periods before and after the construction of selected reservoirs in the Polish Carpathians. RQA shows that the reservoirs in question significantly changed the dynamics of the river flow in terms of the two considered complexity measures, indicating an increase in the regularity, autocorrelation and laminarity of the river flow dynamics for the river section below the reservoirs. Interestingly, the results suggest that the large complex of two reservoirs (Czorsztyn–Sromowce Wyżne) has a weaker impact on the dynamics of the river flow below the dam than the smaller Dobczyce reservoir; this may indicate an important role of the balancing reservoir (Sromowce Wyżne) in mitigating the changes taking place in the affected river system.
A Cloud-Structured Fractal Multiband Antenna for 4G/5G/WLAN/Bluetooth Applications
Authors: Yu Zhen , Zhang Guodong , Ran Xiaoying , Lin Ziheng , Li Yao 
Published: October 2022

This study proposes a multiband printed planar antenna with cloud-like grooves. The outer contour of the antenna is shaped like a cloud, and the groove-like pattern is similar to the cloud-like pattern in ancient China. It can support 3G, 4G, 5G, WLAN, Bluetooth, WiMAX, and other applications. Based on the traditional monopole antenna, the antenna combines the advantages of a coplanar waveguide. The antenna uses an Archimedes helix to create grooves that resemble ancient Chinese cloud structures. Three effective frequency bands are obtained. The relative bandwidth of the first frequency band (1.8–2.6 GHz) is 32.7%, covering 5G band n2 (1.85 GHz–1.99 GHz), WCDMA (1.9–2.17 GHz), LTE33-41 (1.9–2.69 GHz), Bluetooth (2.4–2.48 GHz), WLAN (2.4–2.48 GHz), LTE Band40 (2.3–2.4 GHz), ISM Band (2.42–2.4835 GHz), WiMAX (2.3 GHz), and SCDMA (1.88–2.025 GHz and 2.3–2.4 GHz). The second frequency band (3.35–4.1 GHz) has a relative bandwidth of 20.5%, covering LTE42/43 (3.4–3.8 GHz) and 5G band n78 (3.4 GHz–3.8 GHz). The relative bandwidth of the third band (5.5–7.9 GHz) is 40.3%, covering Emergency and Public Protection (5.85 GHz–5.925 GHz) (WRC03). The antenna is printed on a G10/FR4 dielectric board with a size of

1.6
∗
45
∗
40

m
m

3

, the dielectric constant is 4.4, and the omnidirectional radiation pattern gain is 0.59–4.14 dBi. The measurement results are in good agreement with the simulation results. The proposed design method is verified to meet the requirements of various wireless applications.
PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer
Authors: Hong Juyeong , Lee Ji Hoon , Zhang Zhao , Wu Yanming , Yang Mei , Liao Yiji , de la Rosa Richard , Scheirer Jessica , Pechacek Douglas , Zhang Nu , Xu Zhenming , Curiel Tyler , Tan Xi , Huang Tim H.-M. , Xu Kexin 
Published: October 2022

AbstractThe immunosuppressive tumor microenvironment in some cancer types, such as luminal breast cancer, supports tumor growth and limits therapeutic efficacy. Identifying approaches to induce an immunostimulatory environment could help improve cancer treatment. Here, we demonstrate that inhibition of cancer-intrinsic EZH2 promotes antitumor immunity in estrogen receptor α–positive (ERα+) breast cancer. EZH2 is a component of the polycomb-repressive complex 2 (PRC2) complex, which catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3). A 53-gene PRC2 activity signature was closely associated with the immune responses of ERα+ breast cancer cells. The stimulatory effects of EZH2 inhibition on immune surveillance required specific activation of type I IFN signaling. Integrative analysis of PRC2-repressed genes and genome-wide H3K27me3 landscape revealed that type I IFN ligands are epigenetically silenced by H3K27me3. Notably, the transcription factor STAT2, but not STAT1, mediated the immunostimulatory functions of type I IFN signaling. Following EZH2 inhibition, STAT2 was recruited to the promoters of IFN-stimulated genes even in the absence of the cytokines, suggesting the formation of an autocrine IFN-STAT2 axis. In patients with luminal breast cancer, high levels of EZH2 and low levels of STAT2 were associated with the worst antitumor immune responses. Collectively, this work paves the way for the development of an effective therapeutic strategy that may reverse immunosuppression in cancer.Significance:Inhibition of EZH2 activates a type I IFN-STAT2 signaling axis and provides a therapeutic strategy to stimulate antitumor immunity and therapy responsiveness in immunologically cold luminal breast cancer.
Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer
Authors: Duro-Sánchez Santiago , Nadal-Serrano Mercedes , Lalinde-Gutiérrez Marta , Arenas Enrique Javier , Bernadó Morales Cristina , Morancho Beatriz , Escorihuela Marta , Pérez-Ramos Sandra , Escrivá-de-Romaní Santiago , Gandullo-Sánchez Lucía , Pandiella Atanasio , Esteve-Codina Anna , Rodilla Verónica , Dijcks Fred A. , Dokter Wim H.A. , Cortés Javier , Saura Cristina , Arribas Joaquín 
Published: October 2022

Abstract

Antibody–drug conjugates (ADC) are antineoplastic agents recently introduced into the antitumor arsenal. T-DM1, a trastuzumab-based ADC that relies on lysosomal processing to release the payload, is approved for HER2-positive breast cancer. Next-generation ADCs targeting HER2, such as [vic-]trastuzumab duocarmazine (SYD985), bear linkers cleavable by lysosomal proteases and membrane-permeable drugs, mediating a bystander effect by which neighboring antigen-negative cells are eliminated. Many antitumor therapies, like DNA-damaging agents or CDK4/6 inhibitors, can induce senescence, a cellular state characterized by stable cell-cycle arrest. Another hallmark of cellular senescence is the enlargement of the lysosomal compartment. Given the relevance of the lysosome to the mechanism of action of ADCs, we hypothesized that therapies that induce senescence would potentiate the efficacy of HER2-targeting ADCs. Treatment with the DNA-damaging agent doxorubicin and CDK4/6 inhibitor induced lysosomal enlargement and senescence in several breast cancer cell lines. While senescence-inducing drugs did not increase the cytotoxic effect of ADCs on target cells, the bystander effect was enhanced when HER2-negative cells were cocultured with HER2-low cells. Knockdown experiments demonstrated the importance of cathepsin B in the enhanced bystander effect, suggesting that cathepsin B mediates linker cleavage. In breast cancer patient-derived xenografts, a combination treatment of CDK4/6 inhibitor and SYD985 showed improved antitumor effects over either treatment alone. These data support the strategy of combining next-generation ADCs targeting HER2 with senescence-inducing therapies for tumors with heterogenous and low HER2 expression.

Significance:
Combining ADCs against HER2-positive breast cancers with therapies that induce cellular senescence may improve their therapeutic efficacy by facilitating a bystander effect against antigen-negative tumor cells.
Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine
Authors: O'Connell Casey L. , Baer Maria R. , Ørskov Andreas Due , Saini Sunil Kumar , Duong Vu H. , Kropf Patricia , Hansen Jakob Werner , Tsao-Wei Denice , Jang Hyo Sik , Emadi Ashkan , Holmberg-Thyden Staffan , Cowland Jack , Brinker Brett T. , Horwood Kristin , Burgos Ryan , Hostetter Galen , Youngblood Benjamin A. , Hadrup Sine Reker , Issa Jean-Pierre , Jones Peter , Baylin Stephen B. , Siddiqi Imran , Grønbaek Kirsten 
Published: October 2022

Abstract

Purpose:
We hypothesized that resistance to hypomethylating agents (HMA) among patients with myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) would be overcome by combining a programmed death-ligand 1 antibody with an HMA.

Patients and Methods:
We conducted a Phase I/II, multicenter clinical trial for patients with MDS not achieving an International Working Group response after at least 4 cycles of an HMA (“refractory”) or progressing after a response (“relapsed”) with 3+ or higher risk MDS by the revised International Prognostic Scoring System (IPSS-R) and CMML-1 or -2. Phase I consisted of a 3+3 dose-escalation design beginning with guadecitabine at 30 mg/m2 and escalating to 60 mg/m2 Days 1 to 5 with fixed-dose atezolizumab: 840 mg intravenously Days 8 and 22 of a 28-day cycle. Primary endpoints were safety and tolerability; secondary endpoints were overall response rate (ORR) and survival.

Results:
Thirty-three patients, median age 73 (range 54–85), were treated. Thirty patients had MDS and 3 had CMML, with 30% relapsed and 70% refractory. No dose-limiting toxicities were observed in Phase I. There were 3 (9%) deaths in ≤ 30 days. Five patients (16%) came off study for drug-related toxicity. Immune-related adverse events (IRAE) occurred in 12 (36%) patients (4 grade 3, 3 grade 2, and 5 grade1). ORR was 33% [95% confidence interval (CI), 19%–52%] with 2 complete remission (CR), 3 hematologic improvement, 5 marrow CR, and 1 partial remission. Median overall survival was 15.1 (95% CI, 8.5–25.3) months.

Conclusions:
Guadecitabine with atezolizumab has modest efficacy with manageable IRAEs and typical cytopenia-related safety concerns for patients with relapsed or refractory MDS and CMML.
hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma
Authors: Perera Sheron , Jang Gun Ho , Wang Yifan , Kelly Deirdre , Allen Michael , Zhang Amy , Denroche Robert E. , Dodd Anna , Ramotar Stephanie , Hutchinson Shawn , Tehfe Mustapha , Ramjeesingh Ravi , Biagi James , Lam Bernard , Wilson Julie , Fischer Sandra E. , Zogopoulos George , Notta Faiyaz , Gallinger Steven , Grant Robert C. , Knox Jennifer J. , O'Kane Grainne M. 
Published: October 2022

Abstract

Purpose:
Modified FOLFIRINOX (mFFX) and gemcitabine/nab-paclitaxel (GnP) remain standard first-line options for patients with advanced pancreatic ductal adenocarcinoma (PDAC). Human equilibrative nucleoside transporter 1 (hENT1) was hypothesized to be a biomarker of gemcitabine in the adjuvant setting, with conflicting results. In this study, we explore hENT1 mRNA expression as a predictive biomarker in advanced PDAC.

Experimental Design:
COMPASS was a prospective observational trial of patients with advanced PDAC. A biopsy was required prior to initiating chemotherapy, as determined by treating physician. Biopsies underwent laser capture microdissection prior to whole genome and RNA sequencing. The cut-off thresholds for hENT1 expression were determined using the maximal χ2 statistic.

Results:
253 patients were included in the analyses with a median follow-up of 32 months, with 138 patients receiving mFFX and 92 receiving GnP. In the intention to treat population, median overall survival (OS) was 10.0 months in hENT1high versus 7.9 months in hENT1low (P = 0.02). In patients receiving mFFX, there was no difference in overall response rate (ORR; 35% vs. 28%, P = 0.56) or median OS (10.6 vs. 10.5 months, P = 0.45). However, in patients treated with GnP, the ORR was significantly higher in hENT1high compared with hENT1low tumors (43% vs. 21%, P = 0.038). Median OS in this GnP-treated cohort was 10.6 months in hENT1high versus 6.7 months hENT1low (P &lt; 0.001). In an interaction analysis, hENT1 was predictive of treatment response to GnP (interaction P = 0.002).

Conclusions:
In advanced PDAC, hENT1 mRNA expression predicts ORR and OS in patients receiving GnP.
Tinengotinib (TT-00420), a Novel Spectrum-Selective Small-Molecule Kinase Inhibitor, Is Highly Active Against Triple-Negative Breast Cancer
Authors: Peng Peng , Qiang Xiaoyan , Li Guoyu , Li Lin , Ni Shumao , Yu Qi , Sourd Laura , Marangoni Elisabetta , Hu Chao , Wang Dong , Wu Di , Wu Frank 
Published: October 2022

AbstractTriple-negative breast cancer (TNBC) is a highly heterogeneous cancer lacking actionable targets. Using a phenotypic screen of TNBC cells, we discovered a novel multiple kinase inhibitor tinengotinib (TT-00420) that strongly inhibited Aurora A/B, FGFR1/2/3, VEGFRs, JAK1/2, and CSF1R in biochemical assays. Exposure to tinengotinib specifically inhibited proliferation across all subtypes of TNBC in vitro and in vivo, while leaving luminal breast cancer cells intact. Incubation of HCC1806 with tinengotinib led to dose-dependent downregulation of genes essential for TNBC cell growth and proliferation. Studies revealed that the potential mechanism of action of tinengotinib involved, predominantly, inhibition of Aurora A or B kinase activity, while inhibition of other pathways contributed to suppression of potency and activity. In vitro treatment of TNBC cell lines or in vivo administration in a syngeneic model with tinengotinib resulted in up-regulation of CXCL10 and 11 or diminished tumor-associated macrophage (TAM) infiltration. Tinengotinib represents a novel combinatorial inhibitory mechanism to treat TNBC. The phase I trial of tinengotinib was completed (ClinicalTrials.gov identifier: NCT03654547).
Near-Infrared Photoimmunotherapy Targeting Podoplanin-Expressing Cancer Cells and Cancer-Associated Fibroblasts
Authors: Kato Takuya , Furusawa Aki , Okada Ryuhei , Inagaki Fuyuki , Wakiyama Hiroaki , Furumoto Hideyuki , Fukushima Hiroshi , Okuyama Shuhei , Choyke Peter L. , Kobayashi Hisataka 
Published: October 2022

Abstract
Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an antibody-IRDye700DX (IR700) conjugate that binds to a target followed by the application of NIR light that results in dramatic changes in solubility of the conjugate leading to rapid cell membrane damage and highly immunogenic cell death. NIR-PIT has been used clinically in treating advanced head and neck cancers using an anti-EGFR antibody-IR700 conjugate and has been conditionally approved for clinical use in Japan. NIR-PIT can be employed using a wide range of targeting antibodies. Podoplanin (PDPN), also known as gp38, is a 38 kDa type-1 transmembrane protein associated with lymphatic vessels. In cancer cells and cancer-associated fibroblasts (CAFs), PDPN expression has been widely reported and correlates with poor outcomes in several cancer types. In this study, we evaluated the efficacy of PDPN-targeted NIR-PIT in syngenetic mouse models of cancer. PDPN-targeted NIR-PIT destroyed PDPN-expressing cancer cells and CAFs selectively, suppressing tumor progression and prolonging survival with minimal damage to lymphatic vessels compared with the control group. Interestingly, PDPN-targeted NIR-PIT also exerted a therapeutic effect by targeting CAFs in tumor models which do not express in cancer cells. Furthermore, increased cytotoxic T cells in the tumor bed after PDPN-targeted NIR-PIT were observed, suggesting enhanced host antitumor immunity. Thus, PDPN-targeted NIR-PIT is a promising new cancer therapy strategy for PDPN-expressing cancer cells and CAFs.
Know thy tools! Limits of popular algorithms used for topic reconstruction
Authors: Held Matthias 
Published: October 2022

Abstract
To reconstruct topics in bibliometric networks, one must use algorithms. Specifically, researchers often apply algorithms from the class of network community detection algorithms (such as the Louvain algorithm) that are general-purpose algorithms not intentionally programmed for a bibliometric task. Each algorithm has specific properties “inscribed,” which distinguish it from the others. It can thus be assumed that different algorithms are more or less suitable for a given bibliometric task. However, the suitability of a specific algorithm when it is applied for topic reconstruction is rarely reflected upon. Why choose this algorithm and not another? In this study, I assess the suitability of four community detection algorithms for topic reconstruction, by first deriving the properties of the phenomenon to be reconstructed—topics—and comparing if these match with the properties of the algorithms. The results suggest that the previous use of these algorithms for bibliometric purposes cannot be justified by their specific suitability for this task.
Chapter 1
Authors: Morano Roberta 
Published: October 2022

The first chapter—“Oman, Cornerstone of Arabia”—draws the reader’s attention to the strategic position, both political and historical, of Oman throughout its history. Starting from the most relevant historical and social events that contributed to the development of the linguistic landscape of the Sultanate, the reader is guided through a sociolinguistic analysis of Omani vernaculars. This analysis investigates how specific socio-political circumstances, such as the creation of a new Omani identity after the advent of Sultan Qaboos in the 1970s, partly affected the individual Arabic vernaculars spoken in the northern part of Oman.
The chapter also includes information about bibliographical sources available to date on Omani Arabic, and a detailed description of the methodology used for this study, along with participant and fieldwork site information.
Conclusion
Authors: Morano Roberta 
Published: October 2022

The appendix opens with two sample texts from the various speech recording sessions made by the author during her fieldwork. These two texts represent a monologue and a dialogue and display some of the interesting grammatical features discussed in the book.
To follow the sample texts, the appendix details 14 proverbs collected by the author in Wādī Banī Kharūṣ and al-ʿAwābī with the aim of documenting the local knowledge expressed through popular sayings, as well as creating continuity with Carl Reinhardt’s work. Each proverb is laid out in Arabic script, followed by the transcription and translation, as well as an explanation of the meaning or context of usage. When applicable, the English counterpart is given.
Finally, the appendix includes a traditional song of the Jabal Akhdar region, recited by an old man in Stāl (Wādī Banī Kharūṣ). This song is particularly enlightening because it condenses many of the al-ʿAwābī and Omani-specific traits documented throughout the work.
A Book about People
Authors: de Siqueira Isabel Rocha 
Published: October 2022

The first chapter is about negotiating skills and what makes a diplomat, even if an accidental one. It tells of the many ups and downs one has to endure in politics by looking at the origins of the g7+ as a group. The capacity to navigate these turns is often an echo of complex historical processes of reconciliation in a community; it is also intimately connected to experiences of having had to cope with incredibly steep learning curves.
The accidental diplomats in the g7+ achieved quite a lot against the odds, including the approval of the New Deal in 2011. We should perhaps consider the g7+ both in terms of its being ‘a means to an end’ (international recognition) and ‘an end in itself’ (a parallel system). There is considerable ambivalence about its 'transformative capacities’, something that requires a nuanced analysis. As an exercise in practising diplomacy, there is much to be learned from such experiences, which can furnish future endeavours.
How to Work with Passion
Authors: de Siqueira Isabel Rocha 
Published: October 2022

This chapter is about how to work with passion. This is difficult. Passion helps bring people close, it feeds solidarity, it empowers leadership. But it is also, unfortunately, easily dismissed as a sign of naiveté or a lack of skills. These are real risks, and working with passion requires avoiding these pitfalls.
When the g7+ was established, its overall ambitions were big: the group wanted to achieve important changes on the ground and to fundamentally modify donor behaviour, making cooperation in international development more equal. However, when trying to achieve these goals, passion can’t compensate for preparedness, and personal relationships have their limits. Institutionally, although the close ties of passionate solidarity played an undoubtedly crucial part in what the g7+ has achieved, they are vulnerable to changes in government and to the exhaustion of those involved. That said, although joy, passion and solidarity can’t do everything by themselves, they can still achieve a lot.
How to Decide Where your Pride Fits
Authors: de Siqueira Isabel Rocha 
Published: October 2022

The fifth chapter is about pride. The people in this book have experienced past moments that were full of pride, instilled in them from a young age by family and community. Although there are enormous challenges involved in having to learn how to do their jobs, these struggles are also a reason to be proud and confident later in life. This part of the book, however, is also about the ability to put aside pride in order to do things that others might not deign to do, because the prize ahead is a collective one.
What can puncture a hole in people’s pride is to perceive there is no one listening. To have less power in a broader political agenda can be accommodated; being asked to fill in matrices, worry over formulae, planning ahead according to specific headings and priorities, and then finding all these investments of time and resources go unacknowledged seems to breed more dissatisfaction than other kinds of disappointments. In order to respond, one needs a clear sense of where one’s pride fits in the grand scheme of things. This a matter of both strategy and a sense of duty; a responsibility towards collective goals but also towards one’s own personal story.
How to Act Responsibly
Authors: de Siqueira Isabel Rocha 
Published: October 2022

This chapter is about responsibility and duty. One thing that all the people in this book have in common is their unrelenting belief in the future, their hope for the next generation and their understanding that they have the responsibility to build a sense of responsibility and duty among younger people. There is no room for pessimism.
Motivations vary but this thread is present in many of the stories recorded here. It is important to consider what difference this might make for organisations like those of the g7+, and how it might be harnessed somehow. For anyone living in a country that has seen its share of crises – not necessarily a g7+ member country – it’s not difficult to relate to the feeling that, whilst there is nothing wrong with wanting to live elsewhere, the fact that some people decide to work in difficult contexts is a vital part of any potential path forward for these countries.