bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS PENGGUNAAN SCHOOLOGY DAN ZOOM CLOUD MEETING SEBAGAI MEDIA PEMBELAJARAN JARAK JAUH PADA MATA KULIAH DEKORASI & PENATAAN (AMERICAN SERVICE)
Authors: Siti Triyaningsih  
Published: December 2022

Penelitian ini bertujuan untuk mengetahui efektivitas dari penggunaan media Schoology dan Zoom Cloud Meeting terhadap pembelajaran jarak jauh pada mata kuliah Dekorasi dan Penataan (American Service). Populasi dalam penelitian ini seluruh mahasiswa pendidikan kesejahteraan keluarga angkatan 2020 yang terdiri 93 mahasiswa. Sampel penelitian ini yaitu mahasiswa pendidikan kesejahteraan keluarga angkatan 2020 yang dipilih dua kelas masing-masing terdiri dari 30 mahasiswa. Metode yang digunakan dalam penelitian ini Quasi Experiment dengan desain penelitian Pretest dan Pos test Control Group Design. Teknik pengambilan data menggunakan tes yaitu pretest dan post-test. Teknik analisis data yang digunakan yaitu uji normalitas Kolmogorov-Smirnov dengan taraf signifikan 0,05 maka dtabel= 0,242. Hasil penelitian dengan uji t dan N-Gain, pertama terdapat pengaruh dari media Zoom Cloud Meeting dan Schoology terhadap hasil belajar mahasiswa. Nilai sig pada kelas eksperimen menunjukkan thitungttabel (9>1,679) maka H0 ditolak dan Hi diterima. Pada taraf signifikansi = 0,05 pada dk= (n1+n2)-2= 60-2= 58 pada dua pihak, diperoleh nilai ttabel= 1,671 yang menyatakan bahwa terdapat perbedaan rerata hasil sehingga menunjukkan bahwa Schoology lebih efektif dibandingkan dengan Zoom Cloud Meeting. Hasil penelitian menunjukkan penggunaan media Schoology dapat diterapkan pada mata kuliah praktikum yang ada di Program Studi Pendidikaan Kesejahteraan Keluarga.
Kata Kunci: Media Pembelajaran, Schoology, Zoom
Stepwise Lithospheric Delamination Leads to Pulsed Cenozoic Uplifts of Central Tien Shan
Authors: Zhao Haixiang , Huang Zhouchuan , Yuan Xiaohui 
Published: December 2022

Abstract
The Tien Shan provides an ideal site to study mechanism of intracontinental orogeny due to distant effect of Indo-Asian collision. We investigate lithospheric structures, in particular the lithosphere-asthenosphere boundary (LAB), of Central Tien Shan (CTS) using S wave receiver functions. The results show distinct structures across the orogen. Under the southern CTS, the LAB is shallower than that of the Tarim Basin; a 50 km vertical offset implies that part of the lithosphere has been delaminated. Under the middle CTS, two phases of negative velocity gradient are obtained, which may indicate a new LAB and an ongoing delamination underneath. Under the northern CTS and Kazakh Shield northward, the lithosphere is stable although the LAB inclines southward slightly. The two periods of lithospheric delamination under the southern and middle CTS account well for pulsed uplifts of the Tien Shan at ~11-8 Ma and ~5-0 Ma, respectively.
On using undirected graph techniques for directed graphs through Category Theory
Authors: Guerra Sebastian Prado , George Vivek Kurien , Morar Vikash , Joshua Roldan , Silva Gabriel 
Published: December 2022

Abstract
Many complex systems are modeled as graphs. Depending on the setting, graphs can be either directed or undirected.While many computational tools have been developed for both types of graphs, some tools only exist for undirected graphs.Thus, creating a 'bridge' that connects directed graphs to undirected graphs would unlock the potential for using undirected graph techniques in appropriate directed graph contexts.We used Category Theory in a novel way to map a simple directed graph to a bipartite undirected graph that we call a prime graph.Formally, we show that there exists an isomorphism between the category of simple directed graphs and a category of prime graphs whose objects are labeled undirected bipartite graphs. The labeling is what gives the notion of direction to an undirected graph. By taking advantage of the isomorphism between these two categories, we extend undirected graph techniques to directed graph contexts by converting the directed graphs into prime graphs. We demonstrate this framework by applying it to the problems of network alignment and spectral graph clustering.
Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy
Authors: Yin ZhiJie , Huang YingJie , Chen QiLong 
Published: December 2022

Abstract
Aim
The present study aimed to identify risk factors for venous thromboembolism (VTE) after pancreaticoduodenectomy (PD) and to develop and externally validate a predictive model for the risk of venous thrombosis.
Methods
We retrospectively collected data from 352 patients who visited our hospital to undergo PD from January 2018 to March 2022. The number of patients recruited was divided in an 8:2 ratio by using the random split method, with 80% of the patients serving as the training set and 20% as the validation set. The least absolute shrinkage and selection operator (LASSO) regression model was used to optimize feature selection for the VTE risk model. Multivariate logistic regression analysis was used to construct a prediction model by incorporating the features selected in the LASSO model. C-index, receiver operating characteristic curve, calibration plot, and decision curve were used to assess the accuracy of the model, to calibrate the model, and to determine the clinical usefulness of the model. Finally, we evaluated the prediction model for external validation.
Results
The predictors included in the prediction nomogram were sex, age, gastrointestinal symptoms, hypertension, diabetes, operative method, intraoperative bleeding, blood transfusion, neutrophil count, prothrombin time (PT), activated partial thromboplastin time (APTT), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT), and total bilirubin (TBIL). The model showed good discrimination with a C-index of 0.827, had good consistency based on the calibration curve, and had an area under the ROC curve value of 0.822(P < 0.001, 95%confidence interval:0.761–0.882). A high C-index value of 0.894 was reached in external validation. Decision curve analysis showed that the VTE nomogram was clinically useful when intervention was decided at the VTE possibility threshold of 10%.
Conclusion
The novel model developed in this study is highly targeted and enables personalized assessment of VTE occurrence in patients who undergo PD. The predictors are easily accessible and facilitate the assessment of patients by clinical practitioners.
“Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery”
Authors: Parsak Cem Kaan , Topal Uğur , Altiok Merih , Capkinoglu Emir , Bali Cagla , Yalav Orcun , Rencuzogullari Ahmet 
Published: December 2022

Abstract
Purpose: This study investigated the risk factors associated with mediastinal lymph node metastases due to proximal gastric cancer.
Methods The study included patients who had surgical resection and Transcrural lymphadenectomy for proximal gastric tumors between January 2012 and January 2020. The patients were divided into Group1 (negative) and Group2 (positive) according to the positivity of mediastinal lymph nodes. These groups were compared for clinical variables. The diagnostic value of composite immunonutritional and inflammatory indices in predicting lymph node positivity was examined.
Results There were 88 patients in our study. Group1 included 54 and Group2 included 34 patients.Among the laboratory parameters, only CRP was higher in Group 2 (4.58 vs. 10.7, p= 0.044). The rate of postoperative respiratory complications (5.6% vs. 29.4%, p:0.002) was higher in Group2 The tumor size (25.3 vs. 33 mm, p:0.0001), was higher in Group2. Tumors were more advanced in Group2 (p<0.001). Among the composite indices, only the neutrophil-to-lymphocyte ratio had a diagnostic value, with a sensitivity of 67.65% and a specificity of 55.56% at a cut-off point of >2.19. According to the multivariate analysis, a tumor size of >3 cm, a CRP value of >7, and tumor localization were independent risk factors.
Conlusion Our study found that mediastinal lymph node positivity was associated with elevated CRP and that these patients had more advanced tumors and poor histopathological characteristics. Knowing the relationship between clinicopathological characteristics and mediastinal lymph node positivity in proximal gastric tumors can be useful in determining the surgical strategy for EGJ tumors.
Treatment of Glucocorticoid- induced hyperglycemia in hospitalized patients - A Systematic Review and Meta- Analysis
Authors: Struja Tristan , Nitritz Neele , Alexander Islay , Kupferschmid Kevin , Hafner Jason F. , Spagnuolo Carlos C. , Schuetz Philipp , Mueller Beat , Blum Claudine A. 
Published: December 2022

Abstract
Purpose:Glucocorticoid (GC)-induced hyperglycemia is a frequent issue, however there are no specific guidelines for this diabetes subtype. Although treat-to-target insulin is recommended in general to correct hyperglycemia, it remains unclear which treatment strategy has a positive effect on outcomes. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess whether treating GC-induced hyperglycemia improves clinical outcomes.
Methods: MEDLINE and EMBASE were systematically searched for RCTs on adults reporting treatment and outcomes of GC-induced hyperglycemia since the beginning of the data bases until August 2020. Glucose-lowering strategies as compared to usual care were investigated.
Results: We found 14 RCTs with 595 patients and included seven trials in the quantitative analysis. Patients with an intensive glucose-lowering strategy had lower standardized mean glucose levels of – 0.42 mmol/l (95%CI -0.65 to -0.19) compared to usual care group patients. There was no increase in hypoglycemic events in the intensively treated groups (RR 0.87, 95%CI 0.48-1.56). Overall, we did not have enough trials reporting clinical outcomes for a quantitative analysis with only one trial reporting mortality.
Conclusion: In GC-induced hyperglycemia, tight glucose control has a moderate effect on mean glucose levels with no apparent harmful effect regarding hypoglycemia, but there is insufficient data whether an intensive glucose-lowering strategy improves clinical outcomes.
Systematic review registration
Registered as CRD42020147409 at PROSPERO (https://www.crd.york.ac.uk/prospero/) on April 28, 2020
Early initiation of breastfeeding and associated factors among mothers with children &lt;2 years in Simiyu region, Tanzania
Authors: Shirima Laura J , Mlay Henry L , Mkuwa Serafina , Fabian Agatha , Mushy Stella E. , Ngalesoni Frida N , Mboya Innocent B , Manongi Rachel N 
Published: December 2022

Abstract

Background
Breast milk provides infants with complete nutrition for immune development and protection against childhood diseases. Lack of breastfeeding increases the risk of infant and child morbidity and mortality. Early initiation of breastfeeding (EIBF) aids in the provision of colostrum to newborns, which provides protection against infection and improves newborn and infant survival.
Objective
To determine the prevalence of EIBF and associated factors among mothers with children < 2 years in the Simiyu region, Tanzania.
Methodology:
The study utilized data from a cross-sectional study conducted by AMREF Health Africa among women of reproductive age (15–49 years) in Simiyu region, Tanzania. An interviewer-administered questionnaire was used for data collection. The dependent variable was early breastfeeding initiation, measured by asking women on the time they started to breastfeed their child after birth. Stata 15 was used for data cleaning and analysis. Continuous variables were summarised using mean and standard deviation, while categorical variables using frequency and percentage. A multilevel logistic regression analysis was used to determine factors associated with EIBF.
Results
The mean age of 669 women analyzed was 28.29 years (SD = 6.8). The prevalence of EIBF was 62.2%, ranging from 52.7% in Bariadi district to 73.3% in Maswa district. Lower odds of EIBF were among women who had a caesarian section (OR = 0.41; 95% CI = 0.17–0.98) and those who gave birth to male children (OR = 0.57; 95%CI = 0.39–0.82). And higher odds of EIBF were among mothers who had their babies placed on their chest/abdomen (skin-to-skin-contact) (OR = 2.40; 95%CI = 1.53–3.83) and women from Maswa district (OR = 2.73; 95%CI = 1.09–6.89).
Conclusion
The prevalence of EIBF in Simiyu is slightly lower than the national target (65% by 2025) and good according to the WHO classification. Nonetheless, it’s low in comparison to the global target (70% by 2030). The practice of skin-to-skin contact between mother and child should be encouraged immediately after delivery. Education emphasising EIBF without child sex discrimination should be provided to women at antenatal care (ANC) and in the community at large.
Effectiveness of an Artificial Intelligence Clinical Assistant Decision Support System to Improve the Incidence of Hospital-Associated Venous Thromboembolism: A Prospective, Randomised Controlled Study
Authors: Huang Xiaoyan , Zhou Shuai , Ma Xudong , Jiang Songyi , Xu Yuanyuan , You Yi , Qu Jieming , Shang Hanbing , Lu Yong 
Published: December 2022

Abstract

Background

Thromboprophylaxis has been determined to be safe, effective, and cost-effective for hospitalised patients at venous thromboembolism (VTE) risk. However, Chinese medical institutions have not yet fully utilised or improperly used thromboprophylaxis given the lack of prospective studies; thus, more trials are needed.

Methods

All hospitalised patients aged >18 years not discharged within 24 h from 1 September 2021 to 31 May 2021 were prospectively enrolled. Patients were randomly assigned to the control (9,890 patients) or intervention group (9,895 patients). The control group implemented conventional VTE prevention programmes; the intervention group implemented an Artificial Intelligence Clinical Assistant Decision Support System (AI-CDSS) on the basis of conventional prevention. Intergroup demographics, disease status, hospital length of stay (LOS), VTE risk assessment, and VTE prophylaxis were compared using the chi-square test, Fisher’s exact test, t-test, or Wilcoxon rank-sum test.

Results

The control and intervention groups had similar baseline characteristics. The mean age was 58.32±15.41 years, and mean LOS was 7.82±7.07 days. In total, 5027 (25.40%) and 2707 (13.67%) patients were assessed as having intermediate-to-high VTE risk and high bleeding risk, respectively The incidence of hospital-associated VTE (HA-VTE) was 0.38%, of which 86.84% had DVT. Compared to the control group, the incidence of HA-VTE decreased by 46.00%, mechanical prophylaxis rate increased by 24.00%, and intensity of drug use increased by 9.72% in the intervention group. However, AI-CDSS use did not increase the number of clinical diagnostic tests, prophylaxis rate, or appropriate prophylaxis rate.

Conclusions

AI-CDSS showed a positive role in VTE risk management. Thus, it is necessary to implement evidence-based education programmes to increase physicians’ awareness of thromboprophylaxis and appropriate thromboprophylaxis rates.

Trial registration

This was a randomised controlled single-centre prospective study , which has been reviewed by the World Health Organization International Clinical Trial Registration Platform (11/8/2020, ChiCTR2000035452).
Outcome-adaptive randomisation in a multi-arm breast cancer trial
Authors: Hong Wei , McLachlan Sue-Anne , Moore Melissa , Mahar Robert K. 
Published: December 2022

Abstract

Background
To perform virtual re-executions of a breast cancer clinical trial with a time-to-event outcome to demonstrate what would have happened if the trial had used outcome-adaptive randomisation instead.
Methods
We aimed to retrospectively “re-execute” a randomised controlled trial that compared three chemotherapy regimens for women with metastatic breast cancer (ANZ 0001) using outcome-adaptive randomisation. We used computer simulations to estimate the power and mean number of participants randomised to inferior treatment of a large number of different candidate designs and shortlisted designs with the either highest power or the lowest number randomised to inferior treatment. Using the real-world data, we explored what would have happened had ANZ 0001 been conducted using these shortlisted designs.
Results
We shortlisted seven adaptive randomisation designs that had higher power and a lower number of participants allocated to inferior treatment compared to the original trial design. Adaptive randomised designs were able to reduce the average sample size of the control arm by up to 8.2% when one experimental arm was effective by up to 11.4% when both experimental arms were equally effective. The performance of the adaptive designs when applied to the real-world ANZ 0001 data was consistent with the simulations.
Conclusion
The shortlisted adaptive randomisation designs allocated somewhat fewer participants to inferior treatment while offering the same or better type I and II error rates compared to fixed designs.
Prevalence of hypothyroidism in rheumatoid arthritis and its correlation with disease activity
Authors: jeha Mohamad , jeha Sosana 
Published: December 2022

Abstract
Background: Several recent studies have shown an increased incidence of hypothyroidism in many chronic inflammatory diseases, especially rheumatoid arthritis, and others studies have shown a relationship between hypothyroidism in patients with rheumatoid disease and the degree of disease activity.
Aim of the study: To know the extent of hypothyroidism in a sample of patients with rheumatoid arthritis in Al-Assad and Al-Mowasat University Hospital in Damascus, to link this to the effectiveness of rheumatoid disease, and to compare with a group of healthy controls.
Materials and methods: a cross-sectional/case-control study was conducted on 134 patients diagnosed with rheumatoid arthritis, and a healthy cohort of 134 people from the University Hospitals in Damascus. The presence of hypothyroidism was compared between the two groups of patients and controls. Hypothyroidism in patients was also compared with the disease activity index, after dividing them according to the effectiveness index (DAS28-ESR) into three groups: mild, moderate, and severe disease activity. The data was analyzed using the statistical analysis program (SPSS) version (25) and the variable was considered statistically significant when the P-Value is less than (0.05).
Results: The average age of both patients and controls was (50.6±3.9) and (44.3±2.01) years, respectively. The proportion of females in the sample of patients was (%84.3) and the percentage of females in the control sample (%80.6), the number of patients with hypothyroidism was 43 patients (%32), and the number of infected controls was 10 people (%7.5) P-Value < 0.000. The type of hypothyroidism in patients was classified into clinical hypothyroidism (%67.44) and subclinical hypothyroidism (%32.56). %24.6 of patients and %6 of controls had positive TPO antibodies (P-Value < 0.000). The study has shown a positive correlation between hypothyroidism and disease efficacy indicator (DAS28-ESR).
Conclusion: Increased incidence of hypothyroidism and TPO antibodies in patients with rheumatoid disease compared to healthy subjects, and an increase in the degree of disease activity in patients with rheumatoid disease diagnosed with hypothyroidism compared to patients with rheumatoid disease without hypothyroidism.
A rapid and effective method for obtaining ardicrenin from Ardisia crenata Sims var. bicolor plants
Authors: Lin Zhen , Yang Xiuling , Li Lin , Ma Chunyan , Kong Lingjuan , Li Huancheng , Xiong Shican , Zhong Haiyan , Pu Shangrao , Liang Fang , Hu Ju 
Published: December 2022

Abstract
Ardisia crenata Sims var. bicolor has high ornamental and medical value, especially because it contains the compound ardicrenin, which is a possible alternative drug for Taxol/camptothecin. To protect wild germplasm resources and obtain more ardicrenin, a plant regeneration system was established via calli, and ardicrenin content was quantified by reversed-phase high-performance liquid chromatography (RP-HPLC). The results showed that a Murashige and Skoog (MS) medium with 2,4-dichlorophenoxyacetic acid (2,4-D, 1.0 mg L− 1) and kinetin (KT, 0.01 mg L− 1) was suitable for callus induction, with an induction rate of 95.31 ± 1.62%; a MS medium with 2,4-D (0.5 mg L− 1) and 6-benzylaminopurine (6-BA, 0.2 mg L− 1) was suitable for callus multiplication, with a multiplication coefficient of 359.26; a MS medium with 6-BA (1.0 mg L− 1) and 1-naphthaleneacetic acid (NAA, 0.5 mg L− 1) was suitable for callus differentiation, with a differentiation rate of 89.36 ± 1.39%; and 1/2 MS with indole-3-butyric acid (IBA, 0.2 mg L− 1) was suitable for rooting, with a rooting rate of 93.74 ± 1.38%. Additionally, garden soil: vermiculite: perlite (v: v: v = 1:1:1) was appropriate for acclimatization and transplanting, with a survival rate of 87.38%. RP-HPLC analysis revealed that the ardicrenin content in one-month-old plantlets was higher than that in one-year-old plants and was nearly the same as the content observed in three-year-old plants and two-month-old transplanted plantlets, especially in the roots (17.69 mg g− 1 DW, 1.77% DW). In summary, a rapid propagation system for A. crenata Sims var. bicolor was successfully established for the first time, and the roots of one-month-old plantlets were used to effectively obtain ardicrenin.
Reproductive adverse events in patients with non-Hodgkin lymphoma treated with chemotherapeutic regimens including cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) or CHOP with rituximab (R-CHOP): A systematic review and meta-analysis
Authors: Han Rong , Zhao Jie , Yu Chengjun , Wang Ling , Chen Long , Hu Yang , Lin Tao , He Dawei , Wei Guanghui , Wu Shengde 
Published: December 2022

Abstract
Introduction: The therapeutic regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP) is the first-line treatment regimen for non-Hodgkin lymphoma (NHL). NHL patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP) have a high risk of reproductive adverse events. The aim of this systematic review and meta-analysis was to evaluate the reproductive toxicity of this regimen and make further reasonable suggestions on reproductive protection.
Methods: We systematically searched with appropriate terms from January 1980 to June 2021 for observational studies in adult patients who had the risk of reproductive toxicity associated with the CHOP/R-CHOP regimen, without any language or publication-type restriction. We conducted meta-analyses of one-sample proportions of patients suffering reproductive adverse events after using CHOP/R-CHOP. In addition, subgroup analyses were performed to determine the effect of sex.
Result: A total of 9 articles involving 331 patients were included in the meta-analysis, and the pooled proportion of reproductive adverse events was computed to be 22.3% (95% confidence interval [CI] 11.4%–33.2%; heterogeneity test Q=65.3; τ²=0.0231; I²=87.70%; p<0.001) using the random-effects model. A total of 205 male patients were included in this meta-analysis, which used a random-effects model. The pooled proportion of male gonadal toxicity was 29.2% (95% CI 11. 0%– 47.4%; heterogeneity test Q=46.65; τ²=3.055; I²=89.3%; p<0.0001). The pooled proportion of female gonadal toxicity was 16.5% (95% CI 8.5%– 24.5%; heterogeneity test Q=18.6; τ²=0.0112; I²=67.8%; p=0.005).
Conclusion: The findings suggest that NHL patients have a relatively high risk of reproductive adverse events after treatment with CHOP/R-CHOP. Men are more likely to have gonadal damage than women. Evaluation of reproductive function is particularly necessary both before and after treatment. Some reproductive protection strategies implemented for those patients who want to preserve their fertility.