bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning models for analysis of biomarkers of chronic periodontitis
Authors: Mudrov V. P. 
Published: October 2022

Periodontitis is a multifactorial inflammatory chronic disease initiated by dysbiosis of the commensal microbiota of the oral cavity. With the advent of the multi-ohm approach, which creates datasets with multiple features, machine learning algorithms have become an important technique in translational research. The most effective methods for identifying highly specific interactions of biomarkers with clinical parameters and their implementation in interpretable accurate clinical diagnoses are machine learning algorithms. The aim of the study was to evaluate laboratory diagnostic indicators that are significant for predicting the severity of periodontitis using machine learning models. We examined 133 patients aged 22 to 73 years with a diagnosis of chronic periodontitis, as well as 53 people without periodontal pathology. After the examination and assessment of the condition of the periodontium of patients, a biological sample of the periodontal fluid was taken. Real-time PCR was used to evaluate periodontopathogenic microflora and mRNA of pro-inflammatory cytokines. Cells of innate and acquired immunity were evaluated in mixed saliva. Machine learning was performed using logistic regression algorithms, naive Bayes classifier, ‘the Random Forest’ with 25 % training. When trained to 25 %, the naive Bayes classifier showed an accuracy of 23 %, logistic regression – 29 %. ‘The Random Forest’ showed 100 % accuracy and selected the following biomarkers associated with periodontitis severity: Porphyromonas endodontalis; CD 3+, CD 14+, CD 19+5–B 27+ cells; mRNA IL-1β, IL-10, IL-18, GATA3, TNFa, TLR 4. In chronic periodontitis, there is a relationship between local indicators of the immune-inflammatory process, such as mRNA of pro-inflammatory cytokines, cells of the immune system, and the severity of pathology. In the analysis of a multifactorial disease such as chronic periodontitis, a machine learning model optimized for a large heterogeneous data set with a large patient sample should be used.
Oral status of patients in need of cancer chemotherapy
Authors: Makeeva I. M. , Komogortseva V. E. , Reshetov I. V. , Margaryan E. G. , Put V. A. , Kadzhoyan A. G. 
Published: October 2022

The prevalence and detection of cancer in the world is steadily increasing. The most common methods of treating malignant neoplasms are chemotherapy and/or radiation therapy. Patients undergoing this treatment often experience oral complications. The most common complication is oral mucositis. According to the literature, the probability of its occurrence is from 20 to 80% [2, 3]. Oral mucositis and other complications have a negative impact on the quality of life of cancer patients. They face pain, difficulty eating, swallowing, and damage to the oral mucosa increase the risk of secondary infection.Aim. Evaluation of the dental status of oncological patients starting chemotherapy treatment.Material and methods. The study involved 94 patients aged 45 to 59, who were divided into three groups: 1 – malignant neoplasms of the maxillofacial region (n = 23), 2 – gastrointestinal tract (n = 39), 3 – breast (n = 32). To determine the dental status, the values of the DFM, PMA, OHI-s indices, as well as local factors contributing to the aggravation of the oral cavity (metal structures, sharp edges of the teeth) were studied. To assess the awareness of patients about the rules and methods of maintaining an individual hygienic state of the oral cavity, a survey of patients was conducted.Results. The dental status of cancer patients was assessed. The average value of the DFM index in group I is 13.3 (high), in group II – 11.4 (high), in group III – 5.7 (medium). The average value of the OHI-S index in group I was 3.8 (poor), in group II it was 3.1 (poor), in group III it was 1.7 (poor). The average value of the PMA index in group I was 67 (severe degree of inflammation), in group II – 55.6 (moderate degree of inflammation), in group III – 30.8 (moderate degree of inflammation). According to the survey, low awareness of patients about the means and methods of monitoring individual oral hygiene was revealed. Risk factors have been identified in the form of sharp edges of teeth and metal structures that can contribute to the development of severe complications from the oral cavity during chemotherapy treatment.Conclusion. According to the results of the study, an unsatisfactory dental status of patients with oncological diseases of various localization was revealed. The need for control by dentists is shown.
Analysis of the negative outcomes of the results of prosthetics with bridge-like orthopedic structures in the lateral sections of the dentition
Authors: Komlev S. S. , Bazhutova I. V. , Pugachev S. A. , Razumny V. A. , Zakharova I. A. 
Published: October 2022

Introduction. In the last decade, there has been an increase in publications in the field of odontopreparation using robotic technologies in the literature. The study of patent and literary publications on this subject led to the conclusion that at present the key direction of dentistry is the improvement of various means, methods for diagnosing pathological conditions of the oral cavity through the use of robotic systems. Purpose – to study the long-term results of treatment with fixed bridge structures in the lateral sections of the dentition.Materials and methods. We selected outpatient records of 54 patients who applied to the Samara Regional Dental Polyclinic in the period from 2015 to 2022 with a diagnosis of partial absence of teeth in the posterior region, who underwent orthopedic treatment using bridges. Subsequently, all these patients made a number of complaints about chronic inflammation of the mucous membrane from injuries caused by orthopedic structures, impaired self-cleaning from food residues, impaired fixation of the orthopedic structure, and in some cases, a fracture of the supporting part of the prosthesis or tooth stump.Conclusions. Undoubtedly, for high-quality dental treatment, it is necessary to ensure high-quality visualization of the x-ray picture of the bone tissue in the area of the supporting teeth, as well as take into account excessive chewing loads that may occur during the operation of the bridge. A competent choice of an orthopedic design, as well as compliance with these conditions, makes it possible to ensure the long-term use of orthopedic prostheses with a high degree of probability.
The influence of orthodontic treatment on head posture
Authors: Mamedov Ad. A. , Timoschenko T. V. , Zangieva O. T. , Slynko A. Yu. , Ermakov A. S. 
Published: October 2022

The article presents data of foreign authors on the influence of orthodontic treatment on head posture. Our own study of 102 patients with vertical type of growth and distal occlusion before and after orthodontic treatment was carried out. The effect of rotation of the occlusal plane on the head posture was studied.Materials and Methods: 102 patients with vertical type of growth and distal occlusion were examined before and after orthodontic treatment. Performed cephalometric analysis using CBCT, analyzed the head posture before and after orthodontic treatment.Results: There were significant changes in the parameters characterizing the head position NSL-VER (83,75-82,10), NL-VER (91,55-88,85), NSL-OPT (82,95-85,75), NL-OPT (74,80-76), NSL-CVT (92,80-96,70), NL-CVT (83,30-85,40), и OPT-HOR (81,55-78,15), CVT-HOR (91,90-90,50).Conclusions: 1) Flattening of the occlusal plane during orthodontic treatment affects the position of the head 2) Orthodontic treatment doesn’t effect on bone structures ( SNA, SNB, ANB, WITS, Beta).
Evaluation of the proliferative activity of cell cultures on nanostructured coatings for dental implants
Authors: Dolgalev Al. Al. , Choniashvili D. Z. , Yusupov R. D. , Ambartsumov M. G. , Didenko N. N. , Sergeev Y. A. 
Published: October 2022

The success of implantation treatment largely depends on osseointegration – a stable connection of bone tissue cells with the implant surface. One of the key technical factors on which successful osseointegration depends is the biocompatible surface of the implant.Materials and methods. The authors investigated three series of coatings on prototypes (samples) of titanium implants for biological compatibility: titanium dioxide (TiO2) films obtained by plasma activated atomic layer deposition (PEALD); titanium dioxide (TiO2) films obtained by sol-gel method; diamond-like carbon (DLC) films. Primary cultures of MSCs – mesenchymal stromal cells of rat adipose tissue were used to study proliferative activity.Results. A total of 30 samples were examined, samples made of titanium grade VT6 without coating served as a control. Samples, TiO2 ALD 25 nm, DLC 100 nm and DLC 200 nm, on which cellular elements showed significantly high levels of proliferative activity showed high biological compatibility.
MODEL OF GREENHOUSE GAS EMISSION REDUCTION WASTE SECTOR IN DEPOK CITY
Authors: Fitrisari Agnesika , Rosadi Rosadi , Dewi Indarti Komala 
Published: October 2022

Waste is one of the largest sources of greenhouse gas emission (GHG) at the global, national, and Depok city levels. The purpose of this study was to analyze various alternative of reduction policy scenarios of the GHG waste sector used simulation model with dynamic system approach. The simulation applied from 2020 to 2050. There are four scenarios: BAU scenario, the current waste management; A scenario, based on the Jakstrada program; B scenario, the application of methane gas captured technology on Cipayung landfill, IPAL communal, and Septic tank; C scenario which is the application of Jakstrada program and methane gas captured technology on Cipayung landfill, IPAL communal, and septic tank. The amount of GHG waste sector in Depok 2020 is 414.966,80 Tons CO2/year. The largest amount of emission was originating from wastewater and waste accumulation in landfills, which is 232.053 Tons CO2/year and 173,864,8 Tons CO2/year. A scenario GHG is decreasing by 3,38%. B scenario is decreasing the GHG into 93,6% with 21,99% unmanaged waste and 7% burnt waste. C scenario was successfully decreasing 96,11% and 100% managed waste which is the most. For decreasing the GHG waste sector, it needs the waste management and the technology application are done simultaneously.
Self-reported prevalence and potential factors influencing cardio-cerebral vascular disease among the Chinese elderly: A national cross-sectional study
Authors: Meng Lingbing , Xu Jiapei , Li Jianyi , Hu Jiabin , Xu Hongxuan , Wu Dishan , Hu Xing , Zeng Xuezhai , Zhang Qiuxia , Li Juan , Gong Tao , Liu Deping 
Published: October 2022

BackgroundAging is an essential national condition throughout China in the 21st century. Cardio-cerebral vascular disease (CCVD) is a common chronic vascular disease in the elderly. Despite aging becoming an increasingly pressing issue, there has been no comprehensive national investigation into the risk factors, prevalence, and management of CCVD among the elderly population in China.Materials and methodsThrough the 4th Survey of the Aged Population in Urban and Rural China (SSAPUR), a nationally representative sample of 224,142 adults aged more than 60 years was surveyed using a multistage, stratified sampling method. The 4th SSAPUR was used to investigate CCVD in the elderly. Univariate and multivariate logistic proportional regression analyses explored the risk factors. These risk factors were then entered into a multivariate linear regression model to identify independent predictive factors for CCVD. Disease management was assessed from the self-reported history of physician diagnosis, treatments, and hospital visits among individuals with CCVD.ResultsAfter excluding samples with missing information, 215,041 individuals were included in the analysis. The overall prevalence of CCVD was 26%. Living in a rural area, being older, being female, having low literacy, smoking, getting little sleep, losing a spouse, being single, not getting enough exercise, having a bad financial situation, and not taking part in public welfare programs were the main risk factors for CCVD among the elderly in China (P &lt; 0.05). In the multivariate linear regression model, holding all other variables at any fixed value, CCVD remained associated with “urban and rural” (β = 0.012, P &lt; 0.001), “age” (β = −0.003, P &lt; 0.001), “sex” (β = −0.022, P &lt; 0.001), “education level” (β = −0.017, P &lt; 0.001), “marriage” (β = 0.004, P = 0.047), “smoking” (β = 0.012, P = 0.003), “drinking” (β = −0.015, P = 0.001), and “sleep” (β = 0.008, P = 0.005). There were no collinearity problems among these factors.ConclusionMajor risk factors for prevalent CCVD among the elderly in China include the following: rural residence, female, low literacy level, poor sleep quality, bereavement, non-marriage, living alone, lack of exercise, poor financial situation, and non-participation in public welfare activities. Chinese national policies for preventing, controlling, and managing risk factors for CCVD in the elderly must be urgently developed.
Conversation difficulties rather than language deficits are linked to emotional problems in school children with hearing loss
Authors: Holzinger Daniel , Fellinger Johannes 
Published: October 2022

BackgroundSocial communication difficulties are often associated with neurodevelopmental disorders such as language disorder, intellectual development disorder, attention deficit hyperactivity disorder and autism spectrum disorder, which impedes the investigation of the specific role of social communication problems in mental health outcomes.AimsWe investigated the association between conversation difficulties and increased risk of mental health problems in schoolchildren with hearing loss. It can be assumed of this sample that conversation difficulties are primarily due to limited auditory access to language rather than neurobiological deficits.MethodsFive complete birth cohorts of Carinthian children (n = 53) with significant hearing loss and an intelligence quotient over 70 were assessed in terms of language abilities in standardized tests and in terms of their conversation skills by use of a short teacher checklist developed by the authors. Mental health problems were assessed by means of the Strengths and Difficulties Questionnaire by parents and teachers.ResultsConversation deficits were significantly correlated with lower SDQ emotional problems and total problem scores as rated by parents and lower peer problems scores as rated by teachers. Controlling for degree of hearing loss, maternal education and language skills, confirmed the specific value of conversation skills as a predictor of emotional problems (p = 0.010).ConclusionWith regard to mental health, our results suggest a focus on the assessment of conversation skills in addition to language abilities.
Association between hyperuricemia and metabolic syndrome: A cross-sectional study in Tibetan adults on the Tibetan plateau
Authors: Yao Shaoli , Zhou Yao , Xu Li , Zhang Qi , Bao Shimin , Feng Huiru , Ge Weihong 
Published: October 2022

PurposeThis study aimed to assess the relationship of serum uric acid with metabolic syndrome and its components in Tibetan adults on the Tibetan plateau.MethodsA total of 307 participants were enrolled in this study and biochemical parameters including serum uric acid, fasting plasma glucose, white blood cell, lymphocyte count, mononuclear cells, alanine aminotransferase, aspartate aminotransferase, creatinine, and lipid profile were analyzed using standard methods. The IDF criteria were applied to define metabolic syndrome. The association of serum uric acid with metabolic syndrome and its components was evaluated by multivariable logistic regression models.ResultsThe overall prevalence of metabolic syndrome was 17.3% (53/307) with 19.6% (31/158) in females and 14.8% (22/149) in male participants. The prevalence of hyperuricemia was 40.7% (125/307) with significant differences between the male (53.7%,80/149) and female (28.5%,45/158) groups. In regression analysis, we observed that the risk of MetS was higher in participants in the hyperuricemia group (adjusted OR, 4.01; 95% CI, 2.02~7.99) compared with those in the normouricemia group. After adjusting for all confounding factors, a 9% higher risk of MetS could be shown in participants with SUA increased per 10umol/L (adjusted OR, 1.09; 95% CI, 1.04~1.14). These relationships were not affected by sex or age (p &gt;0.05). After adjusting for the confounding factors, hyperuricemia is positively associated with abdominal obesity (adjusted OR, 2.53; 95% CI, 1.41~4.53), elevated blood pressure (adjusted OR, 2.61; 95% CI, 1.37~4.97), and elevated triglycerides(adjusted OR, 2.47; 95% CI, 1.09~5.57).ConclusionsIn our study, hyperuricemia is significantly associated with the prevalence of metabolic syndrome and part of its components, and these relationships are not affected by sex or age. Given the high prevalence of MetS and hyperuricemia among Tibetan adults, more studies are required to explore the role of SUA in the pathogenesis of MetS.
Fecal microbiota transplantation in patients with post-infectious irritable bowel syndrome: A randomized, clinical trial
Authors: Tkach Sergii , Dorofeyev Andrii , Kuzenko Iurii , Sulaieva Oksana , Falalyeyeva Tetyana , Kobyliak Nazarii 
Published: October 2022

IntroductionResearch in recent years has shown the potential benefits of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS). Acute infectious gastroenteritis is a well-established risk factor for developing such forms of IBS as post-infectious IBS (PI-IBS). However, the effective use of FMT in patients with IP-IBS has not yet been clarified.AimThe study aimed to conduct a single-center, randomized clinical trial (RCT) to assess FMT’s safety, clinical and microbiological efficacy in patients with PI-IBS.Materials and methodsPatients with PI-IBS were randomized into two groups: I (standard-care, n = 29) were prescribed basic therapy, namely a low FODMAP diet, as well as Otilonium Bromide (1 tablet TID) and a multi-strain probiotic (1 capsule BID) for 1 month; II (FMT group, n = 30), each patient with PI-IBS underwent a single FMT procedure with fresh material by colonoscopy. All patients underwent bacteriological examination of feces for quantitative and qualitative microbiota composition changes. The clinical efficacy of treatment was evaluated according to the dynamics of abdominal symptoms, measured using the IBS-SSS scale, fatigue reduction (FAS scale), and a change in the quality of life (IBS-QoL scale).ResultsFMT was associated with rapid onset of the effect, manifested in a significant difference between IBS-SSS points after 2 weeks of intervention (p &lt; 0.001). In other time points (after 4 and 12 weeks) IBS-SSS did not differ significantly across both groups. Only after 3 months of treatment did their QoL exceed its initial level, as well value for 2 and 4 weeks, to a significant extent. The change in the ratio of the main microbial phenotypes in the form of an increase in the relative abundance of Firmicutes and Bacteroidetes was recorded in all patients after 4 weeks. It should be noted that these changes were significant but eventually normalized only in the group of PI-IBS patients who underwent FMT. No serious adverse reactions were noted.ConclusionThis comparative study of the results of FMT use in patients with PI-IBS demonstrated its effectiveness compared to traditional pharmacotherapy, as well as a high degree of safety and good tolerability.
Sleep loss suicidal ideation: the role of trait extraversion
Authors: Killgore William D. S. , Grandner Michael A. , Tubbs Andrew S. , Fernandez Fabian-Xosé , Doty Tracy Jill , Capaldi II Vincent F. , Dailey Natalie S. 
Published: October 2022

Background: It is known that sleep disturbance is associated with increased suicidal thinking. Moreover, completed suicides, when adjusted for the proportion of the populace that is awake at a given time, are more probable during the late night/early morning hours. Despite these concerns, no studies have examined the role of trait-like individual differences in vulnerability to suicidal ideation during sleep deprivation or insomnia. In two separate studies, we examined whether the trait of extraversion is predictive of changes in suicidal thinking following two nights of sleep deprivation and among individuals meeting the criteria for insomnia.Methods:Study 1: Twenty-five healthy military personnel (20 males), ages 20–35 completed the NEO-PI-R Extraversion scale and the Suicidal Ideation (SUI) scale of the Personality Assessment Inventory (PAI). Participants completed 77 h of continuous sleep deprivation. After 56 h of sleep deprivation, participants completed the SUI scale a second time. We predicted a change in SUI scores from baseline extraversion. Study 2: 2,061 adults aged 18–79 (900 males) were divided into two groups based on the clinical threshold (≥ 10) on the Insomnia Severity Index (ISI) and completed measures of extraversion and depression, including the suicide item of the Patient Health Questionnaire-9 (PHQ9).Results:Study 1: After controlling for the caffeine group and changes in PAI Depression, Extraversion scores were used to predict changes in SUI scores using stepwise multiple linear regression. Higher Extraversion was significantly associated with increased non-clinical suicidal ideation following sleep loss, β = 0.463, partial r = 0.512, p = 0.013. Study 2: After controlling for depression, the effect of insomnia on suicidal ideation was moderated by trait extraversion (p &lt; 0.0001). Overall, the presence or absence of insomnia had little effect on individuals low in trait extraversion (i.e., introverts), but insomnia was associated with significantly higher suicidal ideation among high trait extraverted individuals.Conclusions: Higher trait extraversion was associated with increased vulnerability to suicidal ideation between rested baseline and total sleep deprivation and was associated with greater suicidal ideation among those meeting criteria for clinically severe insomnia. These findings point to a potential trait-like vulnerability factor that may further our understanding of sleep disruption in the phenomenology of suicide.