bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Death From Physical Illness or Accidental/Intentional Causes Among Patients With Substance-Related Disorders
Authors: Fleury Marie-Josée , Cao Zhirong , Grenier Guy , Huỳnh Christophe 
Published: November 2022

Objective This study identified patient clinical and sociodemographic characteristics, and, more originally, service use patterns as predictors of death from physical illness or accidental/intentional causes. Methods A cohort of 19,015 patients with substance-related disorders (SRD) from 14 addiction treatment centers was investigated using Quebec (Canada) health administrative databases. Death was studied over a 3-year period (April 1, 2013, to March 31, 2016), and most predictors from 4 years to 12 months prior to the time of death, using multinomial logistic regression. Results Frequent emergency department (ED) use strongly predicted both causes of death, suggesting that outpatient care responded inadequately to patient needs. Only receipt of specialized SRD and psychiatric care significantly decreased the risk of death from physical illness, with trends toward significance for accidental/intentional death. Hospitalization, greater material deprivation and having SRD-chronic physical illnesses or alcohol-related disorders most strongly predicted risk of death from physical illness. Sociodemographic characteristics, mainly social deprivation, were more likely to predict accidental/intentional death. Conclusions Outpatient services could be improved by increasing outreach and motivational interventions and, for ED and hospital units, better screening, brief intervention, and referral to treatment, particularly for men and socially deprived patients at high risk of accidental/intentional death. Patients with more severe health conditions, notably older or materially deprived men at higher risk of death from physical illness, could benefit from programs like assertive community treatment or intensive case management that respond well to diverse and continuous patient needs. Collaborative care between SRD and health services could also be improved.
Mapping Computational Thinking Skills Through Digital Games Co-Creation Activity Amongst Malaysian Sub-urban Children
Authors: Othman Mohd Kamal , Jazlan Syazni , Yamin Fatin Afiqah , Aman Shaziti , Mohamad Fitri Suraya , Anuar Nurfarahani Norman , Saleh Abdulrazak Yahya , Abdul Manaf Ahmad Azaini 
Published: November 2022

This study investigates how digital game co-creation promotes Computational Thinking (CT) skills among children in sub-urban primary schools. Understanding how CT skills can be fostered in learning programming concepts through co-creating digital games is crucial to determine instructional strategies that match the young students' interests and capacities. The empirical study has successfully produced a new checklist that can be used as a tool to describe the learning of CT skills when children co-create digital games. The checklist consists of 10 core CT skills: abstraction, decomposition, algorithmic thinking, generalisation, representation, socialisation, code literacy, automation, coordination, and debugging. Thirty-six 10–12 year-olds from sub-urban primary schools in Borneo participated in creating games in three separate eight-hour sessions. In addition, one pilot session with five participants was conducted. The game co-creation process was recorded to identify and determine how these young, inexperienced, untrained young learners collaborated while using CT skills. Analysis of their narratives while co-creating digital games revealed a pattern of using CT while developing the games. Although none of the groups demonstrated the use of all ten CTs, conclusively, all ten components of the CT were visibly present in their co-created digital games.
Role of Information and Communication Technology in Agricultural Development of India
Authors: Shah Deepak 
Published: November 2022

The desired higher growth in the agricultural sector can be achieved only when there is proper application of information and communication technology (ICT) with adequate investments from both public and private sectors. There is a great scope to implement ICT in order to communicate and integrate the entire agri-food supply chain. The beneficiaries of ICT in agriculture are not only confined to farmers but also encompass food processing companies and suppliers within the agri-food sector. The tools of ICT applications have the potential to provide networking of agriculture sector within the country and globally. It is against this backdrop that the present study not only addresses issues relating to the applications of ICT for economic change in the agricultural sector of India but also identifies the past and present major ICT initiatives in agriculture, the factors responsible for the success of ICT services and the elements of an appropriate framework for assessing the impact of ICT on agricultural development. It is observed that the application of ICT solutions for the development of rural India have been opening a vast range of possibilities to a majority of the population living in rural settings to cross the digital divide. The e-governance strategy for the agriculture sector is capable of exhibiting strategic flexibility to simultaneously integrate the opposing forces. JEL Classification: D83, D85, Q13, Q16
A Prospective, Observational Study of the Spontaneous Reporting Patterns of Adverse Drug Reactions in a Tertiary Care Teaching Hospital
Authors: Raju Santhosh Kumar , S. Geetha , Kamble Shobha 
Published: November 2022

Objectives: To analyse the adverse drug reactions (ADRs) reported from clinical departments of a tertiary care hospital. Materials and Methods: A prospective, observational study to analyse the reported ADRs to the pharmacovigilance unit, Department of Pharmacology, East Point College of Medical Sciences and Research Centre, between 2019 and 2021. Institutional Ethics Committee approval was taken before doing the study. The data pertaining to various parameters were recorded in the Central Drugs Standard Control Organization (CDSCO) approved ADR reporting form and were analysed with respect to each reported data using descriptive statistics and expressed as numbers and percentages using Microsoft Excel. Results: Overall, 114 ADRs were reported during the study duration, and ADRs were most commonly reported amongst females (69) and 31–45 years (27.2%) age group. Causality assessment was done using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) scale, which showed 75 (66%) probable and 39 (34%) possible ADRs. The highest number of ADRs were reported by Medicine department (48.2%), emergency and intensive care unit (ICU) (16.6%) followed by Dermatology department (9.6%). The majority of them were due to antimicrobial agents (53.5%). The most commonly affected organ system was found to be dermatological (68.4%) followed by the body as a whole (15.7%) and gastrointestinal system (8.7%). The presentations of ADRs were diverse; itching and rashes (34 cases) were most commonly reported. Conclusion: This study gives an overall understanding of the current situation and trends in ADRs and their reporting status by health professionals in a tertiary care hospital, which would help to strengthen the pharmacovigilance activities at all levels of health care.
MOG-IgG positive optic neuritis after SARS-CoV-2 infection
Authors: Gilardi Marta , Cortese Antonio , Ferraro Elisabetta , Rispoli Marco , Sadun Riccardo , Altavista Maria Concetta , Sadun Federico 
Published: November 2022

Background Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG. Objective To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger. Methods Retrospective single case report. Results We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection. Conclusion This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.
Pregnancy and multiple sclerosis: 2022 recommendations from the French multiple sclerosis society
Authors: Vukusic Sandra , Carra-Dalliere Clarisse , Ciron Jonathan , Maillart Elisabeth , Michel Laure , Leray Emmanuelle , Guennoc Anne-Marie , Bourre Bertrand , Laplaud David , Androdias Géraldine , Bensa Caroline , Bigaut Kevin , Biotti Damien , Branger Pierre , Casez Olivier , Cohen Mikael , Daval Elodie , Deschamps Romain , Donze Cécile , Dubessy Anne-Laure , Dulau Cécile , Durand-Dubief Françoise , Guillaume Maxime , Hebant Benjamin , Kremer Laurent , Kwiatkowski Arnaud , Lannoy Julien , Maarouf Adil , Manchon Eric , Mathey Guillaume , Moisset Xavier , Montcuquet Alexis , Pique Julie , Roux Thomas , Marignier Romain , Lebrun-Frenay; Christine 
Published: November 2022

Objective: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). Background: MS typically affects young women in their childbearing years. Increasing evidence is available to inform questions raised by MS patients and health professionals about pregnancy issues. Methods: The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed PubMed and university databases (January 1975 through June 2021). The RAND/UCLA appropriateness method was developed to synthesise the scientific literature and expert opinions on healthcare topics; it was used to reach a formal agreement. Fifty-six MS experts worked on the full-text review and initial wording of recommendations. A group of 62 multidisciplinary healthcare specialists validated the final proposal of summarised evidence. Results: A strong agreement was reached for all 104 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and postpartum, delivery routes, locoregional analgesia or anaesthesia, prevention of postpartum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses and disease-modifying treatments. Conclusion: The 2022 recommendations of the French MS society should be helpful to harmonise counselling and treatment practice for pregnancy in persons with MS, allowing for better and individualised choices.
Influential factors of spousal relationship quality in couples living with dementia – A narrative synthesis systematic review
Authors: Stedje Kristi , Kvamme Tone KS , Johansson Kjersti , Stensæth Karette A , Odell-Miller Helen , Bukowska Anna , Tamplin Jeanette , Wosch Thomas , Baker Felicity Anne 
Published: November 2022

Aim The aim of this systematic review is to identify factors that influence relationship quality in couples living with dementia. Previous research has shown how maintaining a positive spousal relationship quality is important for quality of life and coping for both the caregiver and the person with dementia. Knowledge of influential factors could contribute to a deeper understanding of the value of a couple-centred clinical practice and research, within the field of dementia. Research design and methods Systematic procedures to database search, screening, data extraction and synthesis were followed. Qualitative, quantitative and mixed methods studies were included. A narrative synthesis was conducted through narrative summaries of included studies, thematic analysis and narrative descriptions of factors influencing relationship quality. Results 39 studies were included in the study: 28 qualitative, 8 quantitative and 3 mixed methods. Through the narrative synthesis, 20 factors were identified. The factors were grouped into two overarching themes: The world of us and The world outside of us, and further to six influencing factor categories: (1) Attitudes and strategies, (2) Behaviour and activities, (3) Emotional connectedness, (4) Activities and experiences outside of the home, (5) Social behaviour and roles, and (6) Belonging and safety. Discussion and conclusion The identified factors influence relationship quality in couples living with dementia on various levels. The findings of this review study should inform clinical, couple-centred dementia care practise and intervention studies, and further research should seek to gain deeper understandings of the individual factors and broader understandings of the correlations between factors.
How and why have higher education tuition fee policies evolved in England since 1997? A critical discourse analysis of Dearing, Browne and Augar
Authors: Hickey Rob 
Published: November 2022

The last 25 years have seen a dramatic shift in tuition fee policy in England. This paper uses Critical Discourse Analysis to understand the motivations behind policy setting, comparing the pivotal reviews undertaken by Dearing, Browne and Augar. It concludes that four themes may have influenced tuition fee policy making: national politics and political narrative; the marketisation and neoliberalisation of HE; the link between the costs and benefits of education; and the pressures of the economic environment.
Access to Reconstructive Hand Surgery in the United States—Investigating the Obstacles: A Scoping Review
Authors: Kohan Joshua , Mangan Jack , Patel Ashit 
Published: November 2022

Background: Mechanisms that affect access to surgical hand care appear to be complex and multifaceted. This scoping review aims to investigate the available literature describing such mechanisms and provide direction for future investigation. Methods: The methodological framework outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews was used to guide this review. In November 2021, MEDLINE and EMBASE databases were searched. A narrative summary of the characteristics and key findings of each paper is used to present the data to facilitate the integration of diverse evidence. Results: Of 471 initial studies, 49 were included in our final analysis. Of these, 33% were cohort studies; 27% reported that underinsured patients are less likely to get an appointment with a hand specialist or to receive treatment. Overburdened emergency departments accounted for the second-most reported reason (16%) for diminished access to surgical hand care. Elective procedure financial incentives, poor emergency surgical hand coverage, distance to treatment, race, and policy were also notably reported across the literature. Conclusions: This study describes the vast mechanisms that hinder access to surgical hand care and highlights their complexity. Possible solutions and policy changes that may help improve access have been described.
Measuring Potential Visual Exposure of Physicians During Shift-End Handoffs and Its Impact on Interruptions, Privacy, and Collaboration
Authors: Joshi Rutali , Ossmann Michelle , Joseph Anjali 
Published: November 2022

Background: Frequent interruptions, inadequate privacy, and lack of collaboration are barriers to safe and efficient end-of-shift handoffs between emergency physicians. Varying levels of visibility to and from physicians can impact these outcomes. This study quantifies potential visual exposure of physicians in workstations with varying enclosure levels using isovist connectivity (IC) as a measure. Further, this study examines the association of IC with number of interruptions/hour, perceived collaboration, and privacy during handoffs. Methods: In-person observations were conducted during 60 handoffs to capture interruptions. Surveys were administered to the incoming and outgoing physicians to garner their perceptions of the extent of interruptions, collaboration, and privacy. Spatial analysis was conducted using DepthmapX. Results: Findings demonstrate significant differences in IC scores based on (a) physicians location within the workstation during; (b) handoff approach (individual or collaborative); (c) position during handoff (sitting or standing). Documented interruptions were highest in the high IC locations and lowest in the medium and low IC locations. Physicians in low IC locations perceived to have sufficient privacy to conduct handoffs. Limitations and Conclusion: It should be noted that the three pods, each housing a physician workstation with different enclosure levels, varied in number of patient rooms, patient acuity, overall size, and the location of workstations. While contextual variables were considered to the extent possible, several other factors could have resulted in differences in number of interruptions and collaboration levels. This study provides design recommendations for handoff locations and a method to test emergency physician workstation designs prior to construction.
Wayfinding Information Syntheses: A Study of Wayfinding Efficiency and Behavior in Complex Outdoor Institutional Environment
Authors: Iftikhar Hassan , Luximon Yan 
Published: November 2022

Objective: This research aims to investigate the effectiveness of wayfinding information (destination reference images) in real-time complex environmental settings through the syntheses of mobile and static information sources. This investigation will help in improving the wayfinding information design for complex institutional environments which will enhance the environmental legibility. Background: Complex environments are challenging for wayfinding efficiency. Identification of the location and orientation are considered to be important for wayfinding efficiency. This study investigated the user behavior in synthesizing the wayfinding information for identifying the users’ location and orientation in a complex environment. Method: Twenty-five university students have participated in the desktop-based virtual reality experiment. Five experimental conditions were developed for the assessment of wayfinding efficiency and users’ preferred information sources. Results: Reference images of destinations with user-matched angles were found more effective than the building’s facade images. Participants synthesized the mobile wayfinding information with real environmental information to identify their location and orientation. Real environment information (road intersections and shape of the road) and mobile information (reference images of building facades) were found influential in the identification of the user’s location and orientation. Conclusions: The study suggested a need for thorough investigation regarding the users’ wayfinding behavior with different types of environmental information. Future studies have been recommended to investigate other complex institutional environments with larger sample groups for enhancing environmental legibility and institutional efficiency.
Forecasting COVID-19 cases using time series modeling and association rule mining
Authors: Somyanonthanakul Rachasak , Warin Kritsasith , Amasiri Watchara , Mairiang Karicha , Mingmalairak Chatchai , Panichkitkosolkul Wararit , Silanun Krittin , Theeramunkong Thanaruk , Nitikraipot Surapon , Suebnukarn Siriwan 
Published: November 2022

Abstracts
Background
The aim of this study was to evaluate the most effective combination of autoregressive integrated moving average (ARIMA), a time series model, and association rule mining (ARM) techniques to identify meaningful prognostic factors and predict the number of cases for efficient COVID-19 crisis management.

Methods
The 3685 COVID-19 patients admitted at Thailand’s first university field hospital following the four waves of infections from March 2020 to August 2021 were analyzed using the autoregressive integrated moving average (ARIMA), its derivative to exogenous variables (ARIMAX), and association rule mining (ARM).

Results
The ARIMA (2, 2, 2) model with an optimized parameter set predicted the number of the COVID-19 cases admitted at the hospital with acceptable error scores (R2 = 0.5695, RMSE = 29.7605, MAE = 27.5102). Key features from ARM (symptoms, age, and underlying diseases) were selected to build an ARIMAX (1, 1, 1) model, which yielded better performance in predicting the number of admitted cases (R2 = 0.5695, RMSE = 27.7508, MAE = 23.4642). The association analysis revealed that hospital stays of more than 14 days were related to the healthcare worker patients and the patients presented with underlying diseases. The worsening cases that required referral to the hospital ward were associated with the patients admitted with symptoms, pregnancy, metabolic syndrome, and age greater than 65 years old.

Conclusions
This study demonstrated that the ARIMAX model has the potential to predict the number of COVID-19 cases by incorporating the most associated prognostic factors identified by ARM technique to the ARIMA model, which could be used for preparation and optimal management of hospital resources during pandemics.
Clinical profiles, comorbidities, and treatment outcomes of stroke in the medical ward of Dessie comprehensive specialized hospital, Northeast Ethiopia; a retrospective study
Authors: Abdu Hussen , Tadese Fentaw , Seyoum Girma 
Published: November 2022

Abstract
Background:
Undoubtedly, stroke is expanding as a global public health issue. Stroke-related deaths are attributable to modifiable risk factors. A demographic shift in Ethiopia increased the prevalence of stroke risk factors. Furthermore, there is limited relevant information available about stroke. Therefore, the current study sought to evaluate the clinical profiles, comorbidities, and treatment outcomes of stroke in the medical ward of Dessie comprehensive specialized hospital.

Methods:
A retrospective cross-sectional study design was employed among stroke patients. The study included medical records with complete patient information and a stroke diagnosis that had been verified using imaging techniques. Using simple random sampling, 344 medical records were selected, 312 of which met the requirements for inclusion. The frequency and percentage of sociodemographic characteristics and other variables were described using descriptive statistics.

Results:
The patients were 59.2 ± 14.6 years old on average. About 14.7% of the study participants were chat chewers. Of stroke victims, about 52.2% had sensory loss and limb weakness. Nearly 44.9% of the patients had hemiplegia or hemiparesis when they were first seen, and 25.3% were unconscious. Hypertension (63.1%), atrial fibrillation (15.1%), and structural heart diseases (12.5%) were the frequently seen co-morbidities in stroke patients. About 35.8% of the patients had fully recovered and were released go from the hospital without suffering any repercussions. However, hospital deaths from stroke accounted for 21.8% of cases. Stroke fatalities usually involved hypertension, atrial fibrillation, and structural heart disorders.

Conclusion:
Sensory deficits, limb weakness, and mentation loss were all common clinical presentations in stroke patients. In particular, hypertension, atrial fibrillation, and structural heart diseases were commonly seen as comorbidities in stroke patients. Stroke mortality was high in the hospital. Thus, establishing promotive, preventive, curative, and rehabilitative strategies is indispensable.