bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green infrastructure conceptual framework for Kuala Lumpur
Authors: Yeo O T S , Mohd Yusof M J , Maruthaveeran S , Shafri H Z M , Saito K 
Published: July 2022

Abstract
Kuala Lumpur (KL) undergoes significant development since Malaysia independence. Thus, the green spaces in KL are under increasing pressure of decreasing, which lead to fragmentation. Nevertheless, there is a question on how to do Green Infrastructure (GI) planning in KL spatially to solve this problem? The study outlines the conceptual framework of GI planning and establishment in KL. Firstly, a range of literature related to GI, landscape ecology principle, Morphology Spatial Pattern Analysis (MSPA) and landscape connectivity was studied. Subsequently, a conceptual framework was proposed to solve the green space fragmentation. The findings can be a starting point to conduct a GI plan in KL. The study ended by highlighting the main concept of GI in the spatial planning of KL, Malaysia.
Organic field-effect transistors with low-temperature curable high-k hybrid gate dielectrics
Authors: Liu Yiwen , Wang Yongfei , Li Xiao , Hu Zhizhi 
Published: July 2022

Abstract
We report a low-voltage-operated organic field-effect transistor that uses a hybrid gate insulator that has a high dielectric constant k. The gate insulator consists of a high-k polymer cyanoetylated pullulan (CEP) that can be efficiently cross-linked by glycidoxypropyltrimethoxysilane (GOPTMS) at low temperature (∼110 °C). The very low curing temperature is below the glass transition temperature T

g
of conventional plastic substrates for plastic electronics, and is therefore compatible with many plastic substrates for plastic electronics. The cross-linking is very efficient in that only 1/10 (w:w) GOPTMS: CEP produced densely cross-linked thin films with a smooth surface, good insulating property, high capacitance density and high k. The devices functioned at low voltage, and exhibited charge carrier mobility ∼1.83 cm2 V−1 s−1, and steep substheshold swing ∼88 mV dec−1. These results imply that high quality polymer gate insulators are achievable at low temperature with a very small fraction of blended crosslinking agents; this characteristic offers a method to achieve portable all-plastic flexible electronics that function at low voltage.
An Italian Online Survey Regarding the Use of Hyaluronidase in Previously Hyaluronic Acid-Injected Noses Looking for Surgical Rhinoplasty
Authors: Staglianò Samuel , Tartaro Gianpaolo , Bertossi Dario , Pascali Michele , Finocchi Valerio , Zerbinati Nicola , Bove Pierfrancesco , Cirillo Pierfrancesco , Fragola Romolo , Rauso Raffaele 
Published: July 2022

Abstract

Background
Nonsurgical nasal reshaping (nSNR) with hyaluronic acid (HA) filler is a well-established procedure performed to ameliorate nasal appearance and is considered a valid alternative to surgical rhinoplasty in selected patients.

Objectives
The aim of our study is to evaluate the decision-making process and management of patients undergoing rhinoplasty, with previous HA filler injection, and evaluate if consensus could be achieved to recommend guidelines.

Methods
Between April and May 2021, an online survey was sent to 402 Italian surgeons of different specialties. The survey collected information regarding the types of treatment of patients who have previously undergone nSNR, who should undergo surgical rhinoplasty. For those surgeons using hyaluronidase, an additional information was collected.

Results
In a range of time of 2 months (April and May 2021), a total of 72 surgeons replied and completed the survey: out of the 402 questionnaires sent, the response rate was approximately 18%. The majority of respondents (61.5%) replied to inject hyaluronidase (HYAL) in patients who had to undergo a rhinoplasty but reported previous nSNR. Of the surgeons who use HYAL, 70% performed rhinoplasty after a waiting time of 3 to 4 weeks.

Conclusions
Either direct surgical approach or hyaluronidase injection first seems to be a viable options. The use of HYAL before surgery is the choice with the broadest consensus in our survey. However, a larger case-control study with long follow-ups is necessary to understand if in patient seeking surgical rhinoplasty who already received nSNR, the injection of hyaluronidase before surgery is mandatory, recommended, or not.
UV exposure causes energy trade-offs leading to increased chytrid fungus susceptibility in green tree frog larvae
Authors: Cramp Rebecca L , Ohmer Michel E B , Franklin Craig E 
Published: July 2022

Abstract
Levels of ultraviolet (UV) radiation have increased in many parts of the world due to the anthropogenic destruction of the ozone layer. UV radiation is a potent immunosuppressant and can increase the susceptibility of animal hosts to pathogens. UV radiation can directly alter immune function via immunosuppression and photoimmunotolerance; however, UV may also influence pathogen defences by affecting the distribution of energy resources among competing physiological processes. Both defence against UV damage and repair of incurred damage, as well as the maintenance of immune defences and responding to an immune challenge, are energetically expensive. These competing demands for finite energy resources could trade off against one another, resulting in sub-optimal performance in one or both processes. We examined the potential for a disease-related energy trade-off in green tree frog (Litoria caerulea) larvae. Larvae were reared under high- or low-UV conditions for 12 weeks during which time we measured growth rates, metabolic rate and susceptibility to the amphibian fungal pathogen, Batrachochytrium dendrobatidis (Bd). We found that larvae exposed to high levels of UV radiation had higher rates of energy expenditure than those exposed to low UV levels; however, UV exposure did not affect growth rates or developmental timings. Larvae exposed to high UV radiation also experienced greater Bd infection rates and carried a higher infection burden than those not exposed to elevated UV radiation. We propose that the increased energetic costs of responding to UV radiation were traded off against immune defences to protect larval growth rates. These findings have important implications for the aetiology of some Bd-associated amphibian declines, particularly in montane environments where Bd infections are most severe and where UV levels are highest.
The problem of popular culture
Authors: Powers Devon 
Published: July 2022

Abstract
This article argues that concept of popular culture, as conceptualized within the media/cultural studies tradition in the Anglophone West, is in crisis. The idea of the “popular” that continues to be embraced by many critical media/communication and cultural studies scholars derives from postwar assumptions about mass media which no longer accurately fit present conditions. However, the resilience of these assumptions has created “the problem of popular culture,” a complicated and longstanding series of dilemmas for contemporary scholarship. This article documents several manifestations of this problem and proposes that scholars reserve the term popular culture for instances of popular practice.
Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function
Authors: Stancill Jennifer S , Hansen Polly A , Mathison Angela J , Schmidt Edward E , Corbett John A 
Published: July 2022

Abstract
Reactive oxygen species (ROS) have been implicated as mediators of pancreatic β-cell damage. While β-cells are thought to be vulnerable to oxidative damage, we have shown, using inhibitors and acute depletion, that thioredoxin reductase, thioredoxin, and peroxiredoxins are the primary mediators of antioxidant defense in β-cells. However, the role of this antioxidant cycle in maintaining redox homeostasis and β-cell survival in vivo remains unclear. Here, we generated mice with a β-cell specific knockout of thioredoxin reductase 1 (Txnrd1fl/fl; Ins1Cre/+, βKO). Despite blunted glucose-stimulated insulin secretion, knockout mice maintain normal whole-body glucose homeostasis. Unlike pancreatic islets with acute Txnrd1 inhibition, βKO islets do not demonstrate increased sensitivity to ROS. RNA-sequencing analysis revealed that Txnrd1-deficient β-cells have increased expression of nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated genes, and altered expression of genes involved in heme and glutathione metabolism, suggesting an adaptive response. Txnrd1-deficient β-cells also have decreased expression of factors controlling β-cell function and identity which may explain the mild functional impairment. Together, these results suggest that Txnrd1-knockout β-cells compensate for loss of this essential antioxidant pathway by increasing expression of Nrf2-regulated antioxidant genes, allowing for protection from excess ROS at the expense of normal β-cell function and identity.
Enteric bacterial infection in Drosophila induces whole-body alterations in metabolic gene expression independently of the immune deficiency signaling pathway
Authors: Deshpande Rujuta , Lee Byoungchun , Grewal Savraj S 
Published: July 2022

Abstract
When infected by intestinal pathogenic bacteria, animals initiate both local and systemic defence responses. These responses are required to reduce pathogen burden and also to alter host physiology and behavior to promote infection tolerance, and they are often mediated through alterations in host gene expression. Here, we have used transcriptome profiling to examine gene expression changes induced by enteric infection with the Gram-negative bacteria Pseudomonas entomophila in adult female Drosophila. We find that infection induces a strong upregulation of metabolic gene expression, including gut and fat body-enriched genes involved in lipid transport, lipolysis, and beta-oxidation, as well as glucose and amino acid metabolism genes. Furthermore, we find that the classic innate immune deficiency (Imd)/Relish/NF-KappaB pathway is not required for, and in some cases limits, these infection-mediated increases in metabolic gene expression. We also see that enteric infection with Pseudomonas entomophila downregulates the expression of many transcription factors and cell–cell signaling molecules, particularly those previously shown to be involved in gut-to-brain and neuronal signaling. Moreover, as with the metabolic genes, these changes occurred largely independent of the Imd pathway. Together, our study identifies many metabolic, signaling, and transcription factor gene expression changes that may contribute to organismal physiological and behavioral responses to enteric pathogen infection.
Post-seismic motion after 3 Chilean megathrust earthquakes: a clue for a linear asthenospheric viscosity
Authors: Boulze H , Fleitout L , Klein E , Vigny C 
Published: July 2022

SUMMARYOver the last decade, three major subduction earthquakes, Maule Mw 8.8 (2010), Illapel Mw 8.3 (2015) and Iquique Mw 8.1 (2014), occurred in Chile and generated significant post-seismic deformations. These large scale and long lasting deformations can be quantified with modern GNSS precise positioning and highlight viscoelastic processes in the asthenosphere. Here, we calculate the ratios of cumulative post-seismic displacements after 5 yr over the coseismic offsets. We find that at any distance from the trench, ratios are similar for the three earthquakes despite their different magnitudes which imply induced stresses that are more than one order of magnitude apart. This observation suggests that the post-seismic deformation is related to the same effective viscosity for the three earthquakes, indicating Newtonian rheology, rather than power-law rheology in the asthenosphere.
Mechanistic understanding of antibiotic resistance mediated by EnvZ/OmpR two-component system in Salmonella enterica serovar Enteritidis
Authors: Ko Duhyun , Choi Sang Ho 
Published: July 2022

Abstract

Background
Outer membrane porins (OMPs) are a major route for the entry of small hydrophilic antibiotics. Thus, compositional modulation of OMPs is often accompanied by multidrug resistance in a human pathogen Salmonella enterica serovar Enteritidis.

Objectives
The role of EnvZ/OmpR two-component system in antibiotic resistance has not been established except that it regulates the expression of two OMPs, OmpC and OmpF. Here, we have gained mechanistic insight into EnvZ/OmpR-mediated antibiotic resistance in S. Enteritidis.

Methods
The envZP248L and envZH243A strains, mimicking the S. Enteritidis strains with active and inactive states of EnvZ/OmpR, were used in this study. Antibiotic resistance was determined by the broth microdilution method and the spot plating assay. Transcriptomes of the S. Enteritidis strains were analysed by RNA-seq. Western blot, quantitative reverse transcription–PCR, electrophoretic mobility shift assays and β-galactosidase activity assays were performed.

Results
The active state of EnvZ/OmpR induced a differential expression of multiple OMP genes including SEN1522, SEN2875, ompD and ompW, enhancing resistance to β-lactams in S. Enteritidis. OmpR directly activated SEN1522 and SEN2875 but repressed ompD and ompW. Interestingly, an increased cellular level of OmpR determined the expression of the four OMP genes, and phosphorylation of OmpR was even not necessary for the repression of ompD and ompW. EnvZ/OmpR increased its own expression in response to β-lactams, decreasing outer membrane permeability and providing S. Enteritidis with benefits for survival upon exposure to the antibiotics.

Conclusions
EnvZ/OmpR remodels OMP composition in response to β-lactams and thereby enhances antibiotic resistance in S. Enteritidis.
Prompt recovery after surgical treatment of pulmonary and aortic valve endocarditis in a patient with acute heart failure
Authors: Gavalaki Aikaterini , Athanasopoulos George , Roussakis Antonios , Koutouzis Michael , Perreas Konstantinos , Nenekidis Ioannis 
Published: July 2022

Abstract
Infective endocarditis remains a medical challenge among urgent cases of cardiac disease. Multi-valvular endocarditis is uncommon and simultaneous right and left-sided valvular involvement, particularly affecting the pulmonary valve, is scarcely reported. A rare case of a patient with subacute myelodysplastic syndrome, who presented with endocarditis involving both aortic and pulmonary valves, complicated with new-onset heart failure, is described. The patient presented prompt recovery of both right and left ventricular function after combined aortic and pulmonary valve replacement.
Surgical rarities: case report of appendicular diverticulitis and literature review
Authors: Bonomo Luca Domenico , Zago Marcello , Quirico Claudia , Ottinetti Antonio , Panzera Filippo , Galli Alessandra , Gattoni Luca , Canova Gualtiero , Nicotera Antonella 
Published: July 2022

Abstract
Appendicular diverticulosis is a rare condition observed in about 0.004–2% of all appendectomy specimens. Risk of perforation/bleeding is high and a relevant association with mucinous neoplasms is known. Appendectomy is indicated even in case of occasional finding. We present the case of a 22-year-old man who entered the Emergency Room for pain in right iliac fossa. Blood tests showed only a slight increase in C-reactive protein. Abdominal ultrasound (US) evidenced an appendix with thickened walls and a rounded fluid-filled hypoechoic lesion at its distal tip. Laparoscopic appendectomy confirmed the presence of mucocele. Postoperative course was uneventful and the patients discharged on postoperative day 3. Histological examination indicated diverticulitis/peridiverticulitis of the appendix and acute suppurative appendicitis. No perforation of the diverticula was detected. No neoplastic epithelium/mucous material was observed. In our case, preoperative US proved to be a useful alternative to computed tomography for the diagnosis.
TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development
Authors: Meng Yanyan , Zhang Nan , Li Jiatian , Shen Xuehong , Sheen Jen , Xiong Yan 
Published: July 2022

AbstractTo survive and sustain growth, sessile plants have developed sophisticated internal signalling networks that respond to various external and internal cues. Despite the central roles of nutrient and hormone signaling in plant growth and development, how hormone-driven processes coordinate with metabolic status remains largely enigmatic. Target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integrates energy, nutrients, growth factors, hormones, and stress signals to promote growth in all eukaryotes. Inspired by recent comprehensive systems, chemical, genetic, and genomic studies on TOR in plants, this review discusses a potential role of TOR as a ‘global positioning system’ that directs plant growth and developmental programs both temporally and spatially by integrating dynamic information in the complex nutrient and hormonal signaling networks. We further evaluate and depict the possible functional and mechanistic models for how a single protein kinase, TOR, is able to recognize, integrate, and even distinguish a plethora of positive and negative input signals to execute appropriate and distinct downstream biological processes via multiple partners and effectors.
Visceral disseminated varicella zoster virus infection during non-intensive maintenance therapy in a patient with systemic lupus erythematosus
Authors: Hattori Koto , Tanaka Shigeru , Ishikawa Junichi , Yabe Yoko , Iwamoto Taro , Furuta Shunsuke , Ikeda Kei , Suzuki Kotaro , Nakajima Hiroshi 
Published: July 2022

ABSTRACT
Visceral disseminated varicella zoster virus infection (VD-VZV) is a rare complication in immunocompromised patients. Although systemic lupus erythematosus (SLE) patients have a higher risk of VZV infection, only a few reports describe VD-VZV in SLE. Here, we report a 48-year-old woman with SLE who had received maintenance therapy. She was transferred to the hospital because of severe epigastric pain. There were no significant abnormalities in abdominal computed tomography and upper gastrointestinal endoscopy. On hospital day 4, she developed vesicular eruption on her face and abdomen. VZV antigen was detected in specimens obtained from skin lesions, and treatment with acyclovir was started. VZV DNA in blood turned out to be positive, and the epigastric pain was thought to be caused by VD-VZV. There is a risk of VD-VZV in patients with SLE, even in those receiving non-intensive maintenance therapy.
Petaurista philippensis(Rodentia: Sciuridae)
Authors: Koli Vijay Kumar 
Published: July 2022

AbstractPetaurista philippensis (Elliot, 1839), commonly known as the Indian giant flying squirrel or the large brown flying squirrel, is one of the largest flying squirrels. It has a grizzled brown or claret brown coat, and a black-tipped long tail. Petaurista philippensis is distributed in a range of habitats throughout Southeast Asia, reaching a maximum elevation of 2,200 m. It is nocturnal. The International Union for Conservation of Nature has listed it as “Least Concern” (LC) on the global scale, but its populations are declining in many regions. The Indian Government has included it in Schedule II of the Wildlife (Protection) Act, 1972, and Sri Lanka has listed it in Schedule II (Section 30) of the Fauna and Flora Protection (Amendment) Act.
Outline of a Theory of Reasons
Authors: Crupi Vincenzo , Iacona Andrea 
Published: July 2022

AbstractThis paper investigates the logic of reasons. Its aim is to provide an analysis of the sentences of the form ‘p is a reason for q’ that yields a coherent account of their logical properties. The idea that we will develop is that ‘p is a reason for q’ is acceptable just in case a suitably defined relation of incompatibility obtains between p and ¬q. As we will suggest, a theory of reasons based on this idea can solve three challenging puzzles that concern, respectively, contraposing reasons, conflicting reasons, and supererogatory reasons, and opens a new perspective on some classical issues concerning non-deductive inferences.
A New Witness to Two Early Tudor Poems
Authors: Atkin Tamara 
Published: July 2022

Abstract
This article offers an account of a copy of two poems preserved in the binding of Cambridge, Emmanuel College, MSS 4.3.9, a printed Sammelband containing two works published by Johannes Prael in 1531. ‘To my myshap alas I fynd’ and ‘I wyll allthow I may not’ occur in all modern editions of the poetry of Sir Thomas Wyatt, although their attribution to Wyatt remains doubtful. In Cambridge, Emmanuel College, MSS 4.3.9, these poems are copied into the lower endpapers, joined together by five otherwise unattested ‘bridging’ stanzas. A cancelled inscription on the lower pastedown offers some evidence for the scribe’s identity and social milieu and suggests that the textual conversation performed by the poems is an imitation rather than an example of the ‘social textuality’ witnessed in other manuscripts of Wyatt’s verse including Dublin, Trinity College, MS D.2.7, the so-called Blage Manuscript, and London, British Library, Additional MS 17492, the Devonshire Manuscript. Analysing the palaeographic and orthographic features of the hand, the article suggests a mid-Tudor copying date, and by collating variants shows that the versions of ‘To my myshap’ and ‘I wyll allthow I may not’ preserved in Cambridge, Emmanuel College, MSS 4.3.9, may be earlier than those recorded in other known witnesses. Reading the new bridging stanzas alongside other poems by Wyatt, the article shows their indebtedness to well-known tropes and phrases in the Wyatt canon and concludes that the Cambridge MSS 4.3.9 poems function as a Wyattian assemblage that performs a version of the kind of courtly identity found in coterie manuscripts of courtly verse.
An
S
-matrix approach to gravitational-wave physics
Authors: Vanhove Pierre 
Published: July 2022

The detection of gravitational waves emitted by binary systems has opened a new astronomical window into the Universe. We describe recent advances in the field of scattering amplitudes applied to the post-Minkowskian expansion, and the extraction of the effective two-body gravitational potential. The techniques presented here apply to any effective field theory of gravity and are not restricted to four-dimensional Einstein gravity.
This article is part of the theme issue ‘The future of mathematical cosmology, Volume 2’.
Higgs effect without lunch
Authors: Erickson C. W. , Leung Rahim , Stelle K. S. 
Published: July 2022

Reduction in effective space–time dimensionality can occur in field-theory models more general than the widely studied dimensional reductions based on technically consistent truncations. Situations where wave function factors depend non-trivially on coordinates transverse to the effective lower dimension can give rise to unusual patterns of gauge symmetry breaking. Leading-order gauge modes can be left massless, but naturally occurring Stueckelberg modes can couple importantly at quartic order and higher, thus generating a ‘covert’ pattern of gauge symmetry breaking. Such a situation is illustrated in a five-dimensional model of scalar electrodynamics in which one spatial dimension is taken to be an interval with Dirichlet/Robin boundary conditions on opposing ends. The Stueckelberg mode remains in the theory as a propagating scalar degree of freedom from a dimensionally reduced perspective, but it is not ‘eaten’ in a mass-generating mechanism. At leading order, it also makes no contribution to the conserved energy; for this reason, it may be called a (non-ghost) ‘phantom’. This simple model illuminates a mechanism which also has been found in gravitational braneworld scenarios.
This article is part of the theme issue ‘The future of mathematical cosmology, Volume 2’.