bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Trait of Perseverance: A Literature Review and Future Research Directions
Authors: Khindri Aakash , Rangnekar Santosh 
Published: November 2022

Abstract
The concept of perseverance has always allured researchers because of its characterization as an elementary ingredient for success in personal and professional settings. However, past studies show that perseverance has been explored primarily in combination with other constructs, curtailing its development as a standalone concept. This article aims to identify distinct research streams associated with perseverance, reveal how the research associated with the concept has evolved, and identify some ideas and directions for future research. Using bibliometric analysis, the article identifies 3 distinct research streams and a contextual shift in literature over time. Also, emerging trends in the literature are identified through diachronic analysis. The future time perspective theory is suggested to further the research on perseverance.
Schadevergoeding in het ambtenarenrecht
Authors: Balentina A.C. 
Published: November 2022

Schadevergoeding in het ambtenarenrecht
Schadevergoeding staat geregeld in artikel 96 La/RAr. Daarin staat dat als er niet of niet volledig gevolg wordt gegeven aan een veroordeling, in zover zij niet op geld luidt, hetzij in eerste aanleg bij een onherroepelijk geworden beslissing, hetzij in hoger beroep uitgesproken, dan kan de ambtenaar een bezwaarschrift bij het gerecht indienen. Indien het bezwaar gegrond bevonden wordt, veroordeelt het gerecht het betrokken lichaam tot vergoeding en stelt, met inachtneming van alle omstandigheden, het bedrag der schadevergoeding bij de beslissing vast. De rechter geeft daarvoor, zodra de uitspraak in kracht van gewijsde is gegaan, een bevelschrift van tenuitvoerlegging af.
Escola em movimento: A aprendizagem pode “andar” por outro caminho
Authors: Schmitz Heike , Silva Danilo , Tejada Julian 
Published: November 2022

Em diferentes áreas de conhecimento científico e em diversos países, sobretudo em países desenvolvidos, a “Escola em Movimento” se tornou objeto de estudo. Este artigo objetiva apresentar diversas razões teóricas e evidências prévias que levam a recomendar a inserção de atividades físicas em sala de aula. Após uma revisão científica da literatura, considerando predominantemente estudos da Alemanha, resumimos razões a favor da integração de atividade física, oriundas da ergonomia, da fisiologia, da pedagogia da saúde, da educação para a segurança, da ecologia da escola, da teoria educacional, da vida infantil, da antropologia, da psicologia do desenvolvimento e da aprendizagem. Diferenciamos entre atividades de ensino que acompanham a aprendizagem e que facilitam a aprendizagem. A Escola em Movimento promete efeitos positivos no desenvolvimento individual, social e escolar da criança e do jovem. Parece plausível que o movimento contribui na aprendizagem. Isso se justifica teoricamente e está sendo verificado empiricamente, uma vez que o Estado do Conhecimento ainda não se apresenta conclusivo.
Association of Hydroxychloroquine Dose With Adverse Cardiac Events in Patients With Systemic Lupus Erythematosus
Authors: Jimenez Alejandra Londono , Valle Ana , Mustehsan Mohammad Hashim , Wang Shudan , Law Jammie , Guerrero Maria Salgado , Mowrey Wenzhu B. , Horton Daniel B. , Briceno David , Broder Anna 
Published: November 2022

ObjectiveTo determine whether hydroxychloroquine (HCQ) dose is associated with adverse cardiac outcomes in patients with systemic lupus erythematosus (SLE).MethodsPatients with SLE taking HCQ and with ≥1 echocardiogram followed at a tertiary care center in the Bronx, New York between 2005 and 2021 were included. The HCQ weight‐based dose at the HCQ start date was the main exposure of interest. The outcome was incident all‐cause heart failure with reduced ejection fraction (HFrEF), life‐threatening arrhythmia, or cardiac death. We used Fine‐Gray regression models with death as a competing event to study the association of HCQ dose with the outcome. Due to a significant interaction between smoking and HCQ exposure, models were stratified by smoking status. Propensity score analysis was performed as a secondary analysis.ResultsOf 294 patients, 37 (13%) developed the outcome over a median follow‐up time of 7.9 years (interquartile range [IQR] 4.2–12.3 years). In nonsmokers (n = 226), multivariable analysis adjusted for age, body mass index, hypertension, chronic kidney disease, diabetes mellitus, and thromboembolism showed that higher HCQ weight‐based doses were not associated with an increased risk of the outcome (subdistribution hazard ratio [HR] 0.62 [IQR 0.41–0.92], P = 0.02). Similarly, higher baseline HCQ doses were not associated with a higher risk of the outcome among smokers (n = 68) (subdistribution HR 0.85 [IQR 0.53–1.34] per mg/kg, P = 0.48). Propensity score analysis showed comparable results.ConclusionHigher HCQ doses were not associated with an increased risk of HFrEF, life‐threatening arrhythmia, or cardiac death among patients with SLE and may decrease the risk among nonsmokers.
Reduced Self‐Absorption of Quasi‐2D Perovskites and Their Application in Color Conversion Layers
Authors: Liu Nian , Luo Jiajun , Guo Qingxun , Du Peipei , Gao Liang , Niu Guangda , Song Boxiang , Tang Jiang 
Published: November 2022

AbstractLead halide perovskites (LHPs) have recently demonstrated great potential for color conversion layers (CCLs) in backlight displays due to their ultrahigh color purity and high photoluminescence quantum yield. However, the severe self‐absorption effect of LHPs due to small Stokes shift restricts their optical conversion efficiency (OCE) as CCLs. Herein, quasi‐2D perovskites are exploited and the ultrafast energy transfer mechanism is introduced. Using this approach, CCLs Stokes shift is increased and its self‐absorption coefficient is reduced by nearly threefold (from 6.2 × 104 to 2.1 × 104 cm−1). Therefore, color conversion light‐emitting diodes based on quasi‐2D perovskites are demonstrated with an improved OCE of 30% and ideal working stability of 1% loss under blue light irradiation of 35 mW cm−2 indicating their great potential for application in backlight display.
Viruses in sanctuary chimpanzees across Africa
Authors: Dunay Emily , Owens Leah A. , Dunn Christopher D. , Rukundo Joshua , Atencia Rebeca , Cole Megan F. , Cantwell Averill , Emery Thompson Melissa , Rosati Alexandra G. , Goldberg Tony L. 
Published: November 2022

AbstractInfectious disease is a major concern for both wild and captive primate populations. Primate sanctuaries in Africa provide critical protection to thousands of wild‐born, orphan primates confiscated from the bushmeat and pet trades. However, uncertainty about the infectious agents these individuals potentially harbor has important implications for their individual care and long‐term conservation strategies. We used metagenomic next‐generation sequencing to identify viruses in blood samples from chimpanzees (Pan troglodytes) in three sanctuaries in West, Central, and East Africa. Our goal was to evaluate whether viruses of human origin or other “atypical” or unknown viruses might infect these chimpanzees. We identified viruses from eight families: Anelloviridae, Flaviviridae, Genomoviridae, Hepadnaviridae, Parvoviridae, Picobirnaviridae, Picornaviridae, and Rhabdoviridae. The majority (15/26) of viruses identified were members of the family Anelloviridae and represent the genera Alphatorquevirus (torque teno viruses) and Betatorquevirus (torque teno mini viruses), which are common in chimpanzees and apathogenic. Of the remaining 11 viruses, 9 were typical constituents of the chimpanzee virome that have been identified in previous studies and are also thought to be apathogenic. One virus, a novel tibrovirus (Rhabdoviridae: Tibrovirus) is related to Bas‐Congo virus, which was originally thought to be a human pathogen but is currently thought to be apathogenic, incidental, and vector‐borne. The only virus associated with disease was rhinovirus C (Picornaviridae: Enterovirus) infecting one chimpanzee subsequent to an outbreak of respiratory illness at that sanctuary. Our results suggest that the blood‐borne virome of African sanctuary chimpanzees does not differ appreciably from that of their wild counterparts, and that persistent infection with exogenous viruses may be less common than often assumed.
Alternately π‐Stacked Systems Assisted by o‐Carborane: Dual Excimer Emission and Color Modulation by Bcage‐Methylation
Authors: Ochi Junki , Tanaka Kazuo , Chujo Yoshiki 
Published: November 2022

AbstractHerein, we report the unique solid‐state excimer emission of three types of acridine‐tethered o‐carboranes with variable degrees of methylation at the o‐carborane unit. They all showed columnar packing structures based on dimer formation, and two types of π‐overlapping motifs were alternately stacked. From the photoluminescence (PL) measurements on the crystalline samples, it was found that three types of luminescence bands can simultaneously appear: monomer emission, excimer emission from the moderately π‐stacked intra‐dimer unit, and excimer emission from the widely π‐stacked inter‐dimer unit. Consequently, the PL colors were drastically changed by the steric effect of the methyl groups, with a strong correlation found between the π‐overlapping and excimer character. In addition, variable‐temperature PL measurements revealed that these PL species should be in thermal equilibrium at room temperature, with the intensity ratios sensitive toward temperature changes.
Genetic diversity of cryptic species of Bemisia tabaci in Asia
Authors: Lestari Susanti Mugi , Khatun Mst Fatema , Acharya Rajendra , Sharma Sushant Raj , Shrestha Yam Kumar , Jahan S. M. Hemayet , Aye Tin‐Tin , Lynn Ohn Mar , Win Nang Kyu Kyu , Hoat Trinh Xuan , Thi Dao Hang , Tsai Chi‐Wei , Lee Jangha , Hwang Hwal‐Su , Kil Eui‐Joon , Lee Sukchan , Kim Sang‐Mok , Lee Kyeong‐Yeoll 
Published: November 2022

AbstractBemisia tabaci is a species complex consisting of various genetically different cryptic species worldwide. To understand the genetic characteristics and geographic distribution of cryptic species of B. tabaci in Asia, we conducted an extensive collection of B. tabaci samples in ten Asian countries (Bangladesh, Indonesia, Japan, Korea, Myanmar, Nepal, Philippines, Singapore, Taiwan, and Vietnam) from 2013 to 2020 and determined 56 different partial sequences of mitochondrial cytochrome oxidase subunit I (COI) DNA. In addition, information on 129 COI sequences of B. tabaci identified from 16 Asian countries was downloaded from the GenBank database. Among the total 185 COI sequences of B. tabaci, the sequence variation reached to 19.68%. In addition, there were 31 cryptic species updated from 16 countries in Asia, that is, Asia I, Asia I India, Asia II (1–13), Asia III, Asia IV, Asia V, China 1−6, MEAM (1, 2, K), MED, Australia/Indonesia, Japan (1 and 2). Further, MED cryptic species consisted of 2 clades, Q1 and Q2. This study provides updated information to understand the genetic variation and geographic diversity of B. tabaci in Asia.
3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists
Authors: Tocco Graziella , Laus Antonio , Vanejevs Maksims , Ture Anastasija , Mostallino Rafaela , Pintori Nicholas , De Luca Maria Antonietta , Castelli M. Paola , Di Chiara Gaetano 
Published: November 2022

AbstractThe development of novel μ‐opioid receptor (MOR) antagonists is one of the main objectives of drug discovery and development. Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogs were designed, synthesized, and evaluated for their MOR antagonist activity in vitro and in silico. At the highest concentrations, the compounds decreased by 52% to 75% DAMGO‐induced GTPγS stimulation, suggesting that they acted as antagonists. Moreover, Extra‐Precision Glide and Generalized‐Born Surface Area experiments provided useful information on the nature of the ligand–receptor interactions, indicating a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR–ligand complex stability. Interestingly, compound 9 showed the best experimental binding affinity, the highest antagonist activity, and the finest MOR–ligand complex stability. In silico experiments also revealed that the most promising stereoisomer (1R, 3R, 5S) 9 retained 1,3‐cis configuration with phenol ring equatorial oriented. Further studies are needed to better characterize the pharmacodynamics and pharmacokinetic properties of these compounds.
Design of a microfluidic mixer channel: First steps into creating a fluorescent dye‐based biosensor for mAb aggregate detection
Authors: São Pedro Mariana N. , Santos Mafalda S. , Eppink Michel H. M. , Ottens Marcel 
Published: November 2022

AbstractA major challenge in the transition to continuous biomanufacturing is the lack of process analytical technology (PAT) tools which are able to collect real‐time information on the process and elicit a response to facilitate control. One of the critical quality attributes (CQAs) of interest during monoclonal antibodies production is aggregate formation. The development of a real‐time PAT tool to monitor aggregate formation is then crucial to have immediate feedback and process control. Miniaturized sensors placed after each unit operation can be a powerful solution to speed up an analytical measurement due to their characteristic short reaction time. In this work, a micromixer structure capable of mixing two streams is presented, to be employed in the detection of mAb aggregates using fluorescent dyes. Computational fluid dynamics (CFD) simulations were used to compare the mixing performance of a series of the proposed designs. A final design of a zigzag microchannel with 45° angle was reached and this structure was subsequently fabricated and experimentally validated with colour dyes and, later, with a FITC‐IgG molecule. The designed zigzag micromixer presents a mixing index of around 90%, obtained in less than 30 seconds. Therefore, a micromixer channel capable of a fast and efficient mixing is hereby demonstrated, to be used as a real‐time PAT tool for a fluorescence based detection of protein aggregation.
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer
Authors: Yang Yufei , Luo Dakui , Shao Yang , Shan Zezhi , Liu Qi , Weng Junyong , He Weijing , Zhang Ruoxin , Li Qingguo , Wang Ziliang , Li Xinxiang 
Published: November 2022

AbstractBackgroundCircular RNAs (circRNAs) generated by back‐splicing of precursor mRNAs (pre‐mRNAs) are often aberrantly expressed in cancer cells. Accumulating evidence has revealed that circRNAs play a critical role in the progression of several cancers, including colorectal cancer (CRC). However, the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still limited. Here, we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and tumorigenesis.MethodscircRNA microarray was performed with three pairs of tumor and non‐tumor tissues from CRC patients. The expression of circRNAs were determined by quantitative PCR (qPCR) and in situ hybridization (ISH). The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing circRNAs. The regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array, RNA pull‐down/mass spectrometry, RNA immunoprecipitation assay, luciferase reporter assay, chromatin immunoprecipitation analysis, and fluorescence in situ hybridization (FISH).ResultsAmong circRNAs, circCAPRIN1 was most significantly upregulated in CRC tissue specimens. circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients. Downregulation of circCAPRIN1 suppressed proliferation, migration, and epithelial‐mesenchymal transition of CRC cells, while circCAPRIN1 overexpression had opposite effects. RNA sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid metabolism. Moreover, circCAPRIN1 promoted lipid synthesis by enhancing Acetyl‐CoA carboxylase 1 (ACC1) expression. Further mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2 (STAT2) to activate ACC1 transcription, thus regulating lipid metabolism and facilitating CRC tumorigenesis.ConclusionsThese findings revealed the oncogenic role and mechanism of circCAPRIN1 in CRC. circCAPRIN1 interacted with STAT2 to promote CRC tumor progression and lipid synthesis by enhancing the expression of ACC1. circCAPRIN1 may be considered as a novel potential diagnostic and therapeutic target for CRC patients.
Metabolic pathways enriched according to ERG status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer
Authors: Acosta‐Vega Natalia L. , Varela Rodolfo , Mesa Jorge Andrés , Garai Jone , Baddoo Melody C. , Gómez‐Gutiérrez Alberto , Serrano‐Gómez Silvia J. , Lemus Marcela Nuñez , Serrano Martha Lucía , Zabaleta Jovanny , Combita Alba L. , Sanabria‐Salas María Carolina 
Published: November 2022

AbstractBackgroundThe role of ERG‐status molecular subtyping in prognosis of prostate cancer (PCa) is still under debate. In this study, we identified differentially expressed genes (DEGs) according to ERG‐status to explore their enriched pathways and implications in prognosis in Hispanic/Latino PCa patients.MethodsRNA from 78 Hispanic PCa tissues from radical prostatectomies (RP) were used for RNA‐sequencing. ERGhigh/ERGlow tumor groups were determined based on the 1.5‐fold change median expression in non‐tumor samples. DEGs with a False Discovery Rate (FDR) < 0.01 and a fold change >2 were identified between ERGhigh and ERGlow tumors and submitted to enrichment analysis in MetaCore. Survival and association analyses were performed to evaluate biochemical recurrence (BCR)‐free survival.ResultsThe identification of 150 DEGs between ERGhigh and ERGlow tumors revealed clustering of most of the non‐BCR cases (60%) into de ERGhigh group and most of the BCR cases (60.8%) in ERGlow group. Kaplan–Meier survival curves showed a worst BCR‐free survival for ERGlow patients, and a significant reduced risk of BCR was observed for ERGhigh cases (OR = 0.29 (95%CI, 0.10–0.8)). Enrichment pathway analysis identified metabolic‐related pathways, such as the renin‐angiotensin system and angiotensin maturation system, the linoleic acid metabolism, and polyamines metabolism in these ERG groups.ConclusionsERGlow tumor cases were associated with poor BCR‐free survival in our Hispanic/Latino patients, with metabolism‐related pathways altered in the BCR progression.ImpactOur findings suggest the need to dissect the role of diet, metabolism, and lifestyle as risk factors for more aggressive PCa subtypes.
Development of a framework for classifying threat and neglect in childhood: A qualitative study
Authors: Betts Joseph L. , Ownsworth Tamara , Dawe Sharon 
Published: November 2022

AbstractQuantification of childhood adversity has typically involved a cumulative risk approach in which total number of discrete adversities serves as an index of overall risk. However, this approach fails to account for the growing evidence of differential outcomes following exposure to childhood adversities. An alternative approach adopts a dimensional perspective, with growing evidence for distinct developmental impacts associated with exposure to threat (violence/abuse) and deprivation (neglect). This study developed a framework for the classification of these dimensions through a thematic analysis of health practitioners' views and accounts of different forms of childhood adversity. Ten health practitioners experienced in working with children with challenging behaviours and neurodevelopmental disorders participated in semi‐structured interviews regarding definitions and examples of six categories of adversity: physical/emotional/sexual abuse, physical/emotional neglect, and domestic and family violence. The qualitative analysis identified 23 themes across the six categories of adversity, along with two overarching themes regarding ambiguity of classifying exposures and non‐specific outcomes of exposures. Themes were integrated to provide a framework and checklist for classifying indicators of exposure to threat and deprivation. The findings offer a framework and checklist for the assessment of threat and deprivation that will allow for further testing of the dimensional risk model.
Effects of service robots' anthropomorphism on consumers' attribution toward and forgiveness of service failure
Authors: Cheng Li‐Keng 
Published: November 2022

AbstractWe investigated the effects of service robots' anthropomorphism on consumers' attribution and forgiveness of service failure. By manipulating the levels of anthropomorphism in service robots in three experiments, we evaluated the relationship norms and involvement levels of consumers. Three contributions of our study are as follows. First, most human–robot interaction studies have focused on consumers' dissatisfaction with service robots' service failures. Unfortunately, few studies have investigated the influence of service robots' anthropomorphism levels on consumers' internal attribution and forgiveness of service failure. In the present study, we found a positive correlation between the former and the latter. The findings of this study indicate marketing managers should design their service robots to be less anthropomorphic to reduce the likelihood of consumers making an internal attribution when a service failure occurs and increase their forgiveness of service failure. In addition, to reduce the likelihood of consumers' internal attribution upon service failure, managers may ensure that their service robots explain to the consumers the cause of service failure (e.g., inability to understand consumers' requirements and robots' design‐related limitations). Second, consumers' relationship norms moderate the effect of anthropomorphism level on internal attribution. Third, robot anthropomorphism is reportedly effective only when anthropomorphization occurs subconsciously.
Strain echocardiography in a sepsis‐induced cardiomyopathy
Authors: Higny Julien , Bulpa Pierre , Berners Yannick 
Published: November 2022

AbstractSepsis‐induced cardiomyopathy represents a challenging disorder for critical care practitioners in terms of diagnosis, monitoring and treatment. Strain echocardiography may help to identify ventricular dysfunction at precocious stage in critically ill patients. In this manuscript, we describe early impairment in left ventricular systolic function using speckle‐tracking echocardiography.