bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost benefit analysis of the establishment of an environment-based regional owned enterprise (bumd) in the tourism sector in magetan regency
Authors: Juwita A H , Sari V K , Daerobi A 
Published: December 2022

Abstract
Magetan Regency has natural tourism destinations that can be optimized for management. However, the high interest in nature tourism impacts the environment negatively, increasing environmental degradation. Therefore, the Magetan Regency Government must carry out its functions, such as public service, implementation development, and community protection. In this case, the government has planned to form an environment-based local-owned enterprise (BUMD) as an alternative to optimize tourism management by paying attention to the environment. This study aims to analyze the feasibility and benefits of establishing an environment-based local-owned enterprise in Magetan Regency. The methods used cost-benefit analysis with a feasible study approach i.e. Net Present Value (NPV), Internal Rate of Return (IRR), Profitability Index (PI) and Benefit Cost Ratio (BCR) . The feasibility test results found that the NPV was IDR 53,322,599,739, the IRR value was 36.81%, the PI value was 1.67, and since the PI value was > 0, the establishment of the Magetan Regency Tourism Regional Public Company was declared acceptable or feasible. In addition, the BC Ratio value was obtained at 1.45%. Thus, the establishment of an environment-based local-owned enterprise can provide benefits for internal parties and related sectors.
Profit functions of catfish farming for increasing household income in Pekanbaru City Riau Province
Authors: Elinur  , Heriyanto  , Asrol  , Vaulina S 
Published: December 2022

Abstract
The profit of catfish farm is a description of performance of the business, where the profit is determined by output and inputs price. This study aims to analyze of catfish farm profits and determinants of catfish farm profits. This study used a survey method, located in Pekanbaru City. The research data are cross section data what was obtained by using the inverview method, The sampling method used simple random sampling method with 98 catfish farmers, Data analysis used statistical analysis with multiple linear regression. There are several findings: First, catfish farms in Pekanbaru City is profitable. Second, the catfish price, labor wages, feed price PF 1000 depresiation costs are significantly to affect profits, but the price of seed and feed PF 800 do not significantly to effect it. The Third, catfish price s responsive to changes in profit of catfish farm. This is means to changes catfish prices have a major impact on changes in catfish farm profits. However, labor wages, feeds and depreciation cost are not responsive to farm profits. This study recommends that the output price policy is very important for the sustainability of this business.
Building a food sovereign society through indigenous forest establishment policy
Authors: Mayastuti A , Jamin M , Purwadi H 
Published: December 2022

AbstractThe development of multicomplex food sovereignty necessitates a multisectoral approach, which requires cross-sectoral coordination on the part of the government as the policymaker in the food sector in order to build effective food security at the national level in Indonesia. The goal of this research is to encourage the Indonesian government to build a local food system through empowering local farmers especially indigenous peoples after the establishment of customary forests. The research is doctrinal legal research with a statutory approach using the hermeneutic interpretation method. The results showed that the participation of regional food agencies remains minimal in reality. This institutional crisis within the government’s food sovereignty agencies, coupled with a lack of political commitment and political will, has implications for the failure of food security programs in Indonesia. In order to achieve food sovereignty in Indonesia, Constitutional Court Decision No. 25/PUU-X/2012 becomes the primary basis for strengthening the rights of indigenous communities over indigenous forest ownership. Food sovereignty can only be reached by mastering green technology that fits the needs of indigenous peoples and is based on their traditional ways of doing things so that a follow-up policy that favors indigenous peoples is needed.
The impact of the Russia-Ukrainian war on green energy financing in Europe
Authors: Saktiawan B , Juan Suam Toro M , Saputro N 
Published: December 2022

Abstract
The energy crisis started because of the war between Russia and Ukraine and European countries’ imposition of economic sanctions. Russia supplies 40% of gas and 25% of crude oil to most European countries. In retaliation for the sanctions, Russia required the purchase of its gas and oil in its ruble. However, this policy was rejected by European countries, resulting in reduced energy supply as the price of gas and oil rose. European countries are trying to reduce Russia’s energy dependence by looking for environmentally friendly energy alternatives. As the first step, European countries increase the budget for developing environmentally friendly energy. This paper use data from the European Commission (EC), Eurostat, Greenmatch, and the World Bank. The author finds that European countries have increased the budget for developing and using environmentally friendly energy to remove the dependence on gas and oil energy from Russia. European countries believe that environmentally friendly energy can become the primary energy resource in the future.
Effect of various photoperiods towards lollo bionda growth using IoT based lighting control for indoor hydroponic farming system
Authors: Shafie A M M , Azlan A , Sariman M Z , Mustafa M M B , Sulaiman H , Fairuz K 
Published: December 2022

Abstract
Sustainable agriculture is actively developed to ensure food security which is a major threat to the world population in 2050 as projected by the Food and Agriculture Organization (FAO). The increasingly limited agricultural land nowadays makes indoor farming the best. Indoor farming is the method of growing crops in vertically stacked layers by implementing hydroponic and artificial light. Light Emitting Diodes (LEDs) have been widely used to mimic sunlight for plant growth. However, every plant growth depends on the difference optimal value of light quality (light spectrums) and quantity (photoperiod). This study investigates the effect of light exposure on Lollo Bionda growth and determines which growing environment will provide optimum results in growing Lollo Bionda. This study conducted four types of experiments with different photoperiod treatments, namely T1 (no light exposure), T2 (24 hours), T3 (18 hours) and T4 (12 hours), with six replicates. The results show significant differences between each treatment mean. T2 provides the most significant result for all parameters compared to other treatments. In summary, light exposure helps in the productivity consistency in terms of weight, height and average leaf size of Lollo Bionda. This finding can be beneficial to the small-medium size entrepreneur.
Land function transfer: The transformation of agriculture land to agriculture tourism sites in Polobogo, Semarang
Authors: Wijayanto N , Agfianto T , Najicha F U , Nugroho A A 
Published: December 2022

Abstract
Polobogo is one of villages in Semarang Regency that has begun using their land asset for tourism activities. It is because the agricultural activities that have been carried out so far have not significantly impacted either the government as the owner or the community in general. The income only receives from the annual harvest, which is still far from sufficient in nominal terms. Therefore, the stakeholders try to use the land as a tourist attraction with the concept of agro-tourism. This study aimed to evaluate the potential of Polobogo village to be used as an agro-tourism attraction by utilizing its natural resources. The approach in this study uses descriptive qualitative where direct observation, in-depth interviews, study documentations, and literature review are used to answer the existing problems. The data obtained were processed using the triangulation method. The study results indicate that Polobogo Village has good tourism potential, which can be seen from its several natural resources. The consolidation of the village government and the community needs to be done more intensely in order to create a more optimal tourism industry. Planning documents, village regulations or village head decrees, related to business management must be formed to improve agro-tourism utilization.
Pari Klegung ‘The River Whisper’ in Kulon Progo Indonesia eco friendly study (local potential as an environmentally friendly effort)
Authors: Studyanto Anung B , Purwasito Andrik , Warto  , Widayat Rahmanu 
Published: December 2022

Abstract
On the banks of the Klegung River, often known as ‘The River Whisper’, in the Kulon Progo district of the Special Region of Yogyakarta, is a brand-new culinary tourism destination called Pari Klegung. The idea behind the construction of Pari Klegung was to bring people and environment closer together. This article serves as an introductory study, using Pari Klegung ‘The River Whisper’ as an example of an ecologically friendly design observation. The following research will use more thorough methodologies and information. In addition to conducting interviews with respondents, this research method makes use of architectural and environmental observation techniques. Pari Klegung is distinctive due to the land’s organic shape, which follows the existing terrain’s contours, attempts to conserve greenery, a predominance of local materials in structures, an display of river cultural relics as a celebration of local culture, and participation of locals in management. Pari Klegung ‘The River Whisper’, created by Eko Prawoto, can serve as an example of how to incorporate environmentally friendly building practices in a freshly constructed setting, with ecological elements playing a significant role in it. As part of an endeavor to increase the presence of local potential, provide value and advantages to the neighborhood of Pari Klegung.
Repeatability and most probable producing ability of egg weight and one-day-old chick weight in Merawang chicken
Authors: Solekah S , Sari A P Z N L , Saraswati Y V , Sasongko H , Maharani D 
Published: December 2022

AbstractLocal Indonesian chicken from Bangka Belitung is known as Merawang. This chicken has dual purposes as a meat and egg producer. The objective of this study was to determine the repeatability and most probable producing ability (MPPA) of Merawang chicken’s egg weight and one-day-old chick (DOC) weight. 72 pullet Merawang chickens were raised in single bird cages and their egg weight was checked at 36-38 and 56-58 weeks. The DOC was weighed after the eggs were hatched. The rptR package and the restricted maximum likelihood (REML) method were utilized to estimate the repeatability. At 36-38 and 56-58 weeks, the average egg weight was 46.435.44 and 52.146.15, respectively. Meanwhile, the average DOC weight at 36-38 and 56-58 weeks were 31.92±4.54 and 35.40±4.36, respectively. The result showed that at 36-38 and 56-58 weeks, the repeatability of egg weight was 0.77±0.05 and 0.69±0.05, whereas the DOC weight was 0.84±0.04 and 0.64±0.07. The average MPPA ranges based on egg and DOC weights were 46.51-52.23 and 31.97-35.52, respectively. The pullets with MPPA above the average were 38.46%-50.72% (egg weight) and 48.94%-56% (DOC weight). The results from this study can be used for selecting the Merawang pullet.
The effect of collaboration between elements for the progress of rubber cooperatives in Riau Province, Indonesia
Authors: Rahmadani E , Khoiriah  , Maryani A T 
Published: December 2022

Abstract
The rubber cooperative is an important agency to support the economy of the rubber farmer groups in Riau Province. But the number of active cooperative decline since 2014 - 2020. The goal of this study is to assess the aspect of collaboration between elements against cooperative progress. This research was examined both inactive and active cooperatives as a comparison. The chosen locations are the largest rubber producer in Riau Province namely, Kuantan Singingi Regency and Kampar Regency. The samples were taken by purposive sampling with amount of 300 people representing 150 from active cooperative and 150 from inactive one. The research samples were the elements of the rubber farmer cooperative consisting members, management, supervisors and employees. The data was carried out by structured and in-depth interviews. The collaboration was studied based on the interaction between cooperative elements with 8 indicators. The value resulted from the active rubber cooperative in this parameters is good-very good (76.10% -82.80%). In contrast, inactive cooperatives obtain very bad – good enough (20.00% - 60.00%). The main problems in inactive cooperatives come from the interactions between members and employees (X3), management with employees (X5) and supervisors with employees (X6) because all eight indicators have bad scores.
Chromosome of Phaius tankervilleae and Phaius amboinensis Orchid
Authors: Hartati S , Parjanto  , Sukaya  , Muliawati E S , Nandariyah  , Yuniastuti E , Manurung I R , Purmiyoto C W W 
Published: December 2022

Abstract

Phaius tankervilleae and Phaius amboinensis orchids are decorative orchids that have great ornamental value and are classified as endangered plants. Genetic information from the Phaius tankervilleae and Phaius amboinensis orchids will facilitate plant breeding as a basis information to obtain improvements in ornamental plant properties. The purpose of chromosome analysis is to determine the shape, number, and size of chromosomes. The research was conducted at the Cytology Laboratory of the LIPI Biology Research Center, Bogor, West Java. The results of the observations were analyzed descriptively based on the observation of the chromosome images from the photo shoot and the data on the size and shape of the chromosomes. It is known that the Phaius tankervillae has a chromosome number of 2n=2x=44 and Phaius amboinensis has a chromosome number of 2n=2x=46. The average length of the long arm of the Phaius tankervillae chromosome was 1.25 ± 0.45 μm with the short arm of 1.13 ± 0.43 μm. The long arm length of the Phaius amboinensis orchid chromosome is 1.25 ± 0.44 μm with the short arm 1.06 ± 0.37 μm. Phaius tankervillae and Phaius amboinensis both have metacentric chromosomes meta.
MDSCs in pregnancy and pregnancy-related complications: an update
Authors: Shah Neelam Kumari , Xu Peng , Shan Yanhong , Chen Chen , Xie Min , Li Yan , Meng Yizi , Shu Chang , Dong Shuai , He Jin 
Published: December 2022

AbstractMaternal–fetal immune tolerance is a process that involves complex interactions of the immune system, and myeloid-derived suppressor cells have emerged as one of the novel immunomodulator in the maintenance of maternal-fetal immune tolerance. Myeloid-derived suppressor cells are myeloid progenitor cells with immunosuppressive activities on both innate and adaptive cells through various mechanisms. Emerging evidence demonstrates the accumulation of myeloid-derived suppressor cells during healthy pregnancy to establish maternal–fetal immune tolerance, placentation, and fetal–growth process. By contrast, the absence or decreased myeloid-derived suppressor cells in pregnancy complications like preeclampsia, preterm birth, stillbirth, and recurrent spontaneous abortion have been reported. Here, we have summarized the origin, mechanisms, and functions of myeloid-derived suppressor cells during pregnancy along with the recent advancements in this dynamic field. We also shed light on the immunomodulatory activity of myeloid-derived suppressor cells, which can be a foundation for potential therapeutic manipulation in immunological pregnancy complications.
Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells
Authors: Zhang Donghai , Yu Yongsheng , Ding Chuanfeng , Zhang Ruonan , Duan Tao , Zhou Qian 
Published: December 2022

AbstractThe cause for at least 50% of recurrent miscarriages is unclear, which is defined as unexplained recurrent miscarriages. The B7-H1 (PD-L1), a molecule of the B7 family, promotes tumor development by modulating immune evasion, and recent researchers have also attached importance to the role of B7-H3, another molecule of B7 family, in tumor. Based on the similarity between growth and immune response in tumors and pregnancy, we first explored the role of B7-H3 in unexplained recurrent miscarriages. We found reduced levels of B7-H3 in the villus tissue of unexplained recurrent miscarriage patients, and it was mainly expressed on the cell membrane of extravillous trophoblasts. Further, the HTR-8/SVneo and JEG-3 cells were selected to explore the role of B7-H3 in proliferation, apoptosis, tube formation, migration, and invasion. We found that B7-H3 regulated trophoblast migration and invasion via RhoA/ROCK2 signaling pathway. Inflammatory cytokines were detected through enzyme-linked immunosorbent assay after co-culturing with decidual natural killer cells and B7-H3-knockout JEG-3. Results showed that B7-H3 inhibited IL-8 and IP-10 secretion from the decidual natural killer cells. In a CBA/J × DBA/2 abortion-prone mice model, treatment with B7-H3-Fc protein successfully reduced the rate of embryo resorption. In conclusion, our results revealed a possible mechanism by which decreased B7-H3 on trophoblasts of unexplained recurrent miscarriages inhibited trophoblast migration and invasion and increased IL-8 and IP-10 secretion from the decidual natural killer cells. Furthermore, B7-H3 may be a promising new therapeutic target in unexplained recurrent miscarriage patients.
Comparison of Proteomic Measurements Across Platforms in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Rooney Mary R , Chen Jingsha , Ballantyne Christie M , Hoogeveen Ron C , Tang Olive , Grams Morgan E , Tin Adrienne , Ndumele Chiadi E , Zannad Faiez , Couper David J , Tang Weihong , Selvin Elizabeth , Coresh Josef 
Published: December 2022

Abstract

Background
The plasma proteome can be quantified using different types of highly multiplexed technologies, including aptamer-based and proximity-extension immunoassay methods. There has been limited characterization of how these protein measurements correlate across platforms and with absolute measures from targeted immunoassays.

Methods
We assessed the comparability of (a) highly multiplexed aptamer-based (SomaScan v4; Somalogic) and proximity-extension immunoassay (OLINK Proseek® v5003; Olink) methods in 427 Atherosclerosis Risk in Communities (ARIC) Study participants (Visit 5, 2011–2013), and (b) 18 of the SomaScan protein measurements against targeted immunoassays in 110 participants (55 cardiovascular disease cases, 55 controls). We calculated Spearman correlations (r) between the different measurements and compared associations with case-control status.

Results
There were 417 protein comparisons (366 unique proteins) between the SomaScan and Olink platforms. The average correlation was r = 0.46 (range: −0.21 to 0.97; 79 [19%] with r ≥ 0.8). For the comparison of SomaScan and targeted immunoassays, 6 of 18 assays (growth differentiation factor 15 [GDF15], interleukin-1 receptor-like 1 [ST2], interstitial collagenase [MMP1], adiponectin, leptin, and resistin) had good correlations (r ≥ 0.8), 2 had modest correlations (0.5 ≤ r &lt; 0.8; osteopontin and interleukin-6 [IL6]), and 10 were poorly correlated (r &lt; 0.5; metalloproteinase inhibitor 1 [TIMP1], stromelysin-1 [MMP3], matrilysin [MMP7], C-C motif chemokine 2 [MCP1], interleukin-10 [IL10], vascular cell adhesion protein 1 [VCAM1], intercellular adhesion molecule 1 [ICAM1], interleukin-18 [IL18], tumor necrosis factor [TNFα], and visfatin) overall. Correlations for SomaScan and targeted immunoassays were similar according to case status.

Conclusions
There is variation in the quantitative measurements for many proteins across aptamer-based and proximity-extension immunoassays (approximately 1/2 showing good or modest correlation and approximately 1/2 poor correlation) and also for correlations of these highly multiplexed technologies with targeted immunoassays. Design and interpretation of protein quantification studies should be informed by the variation across measurement techniques for each protein.
Provocative testing using low dose oral flecainide for diagnosis of Brugada syndrome: a report of two cases
Authors: Amir Muzakkir , Kabo Peter , Rahma Iznaeny 
Published: December 2022

Abstract

Background
Brugada syndrome (BrS) is a genetic disease characterized by coved ST-segment elevation in the right precordial leads that predispose to life-threatening ventricular tachyarrhythmia. The electrocardiographic signature is dynamic and often concealed but can be unmasked by potent sodium channel blockers such as Flecainide. Some studies have evaluated the effectivity of oral Flecainide 400 mg for provocative testing, but clinical utility of lower dose Flecainide (300 mg) has never been documented.

Case summary
These two cases illustrate the effectiveness of low dose oral Flecainide to unmask Brugada electrocardiographic pattern. In our patients, diagnostic type 1 electrocardiography started to develop 30 min after drug administration and reached maximal positivity at 3.5–4.5 h. No atrioventricular block or ventricular arrhythmia was observed during the procedures.

Discussion
A potent sodium channel blocker facilitates marked reduction of the right ventricle epicardial action potential, which creates a transmural voltage dispersion and manifests as an ST elevation in the right precordial leads. Time to positivity was comparably rapid, and time to maximal ST-elevation appeared close to peak plasma level of Flecainide (ranging from 1 to 6 h). Although asymptomatic patients have a low rate of adverse cardiac events, it is crucial to inform patients to avoid various modulators and precipitating factors that could trigger malignant arrhythmias.