bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Vitamin D, Cardiovascular Health, and Periodontitis in US Adults
Authors: yang Fu , lei Sun 
Published: January 2025

Abstract

Background
Vitamin D deficiency is a prevalent public health issue, and serum vitamin D concentrations are linked to the risk of periodontitis. This study aims to investigate the relationship between these two variables and to determine whether this association is influenced by various factors, particularly focusing on the mediating effect of cardiovascular health (CVH).
Methods
Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for the years 2009–2014 in this cross-sectional study. The association between vitamin D and periodontitis was examined using univariate and multivariate logistic regression analyses, as well as restricted cubic spline models. Additionally, subgroup analyses and restricted cubic splines were employed to assess the effects of glucose tolerance status, age, gender, smoking status, and alcohol consumption on the association. Mediation analysis was conducted to explore whether LE8 scores serve as a mediator in the relationship between vitamin D and periodontitis.
Results
Among 12,714 adults, 4,522 (35.5%) were diagnosed with periodontitis, with the proportions of Mild, Moderate, and Severe Chronic Periodontitis being 279 (2.2%), 3,438 (27.0%), and 805 (6.3%), respectively. After fully adjusting for confounding factors, negative associations were observed between vitamin D levels and periodontitis. Quartile comparisons indicated Q2: 0.91 (0.82 ~ 1.00), Q3: 0.88 (0.79 ~ 0.99), and Q4: 0.89 (0.78 ~ 1.01). In subgroup analyses, vitamin D was significantly associated with periodontitis across various strata, including age, sex, and glucose tolerance status. Interaction analysis revealed that age significantly influenced the relationship between vitamin D and periodontitis. Mediation analyses utilizing Life's Essential 8 (LE8) assessed cardiovascular health (CVH), demonstrating that the LE8 score and health factor score mediated the relationship between vitamin D and periodontitis, with mediation proportions of 8.71% and 7.11%, respectively.
Conclusion
We concluded that increased vitamin D levels were associated with a decreased risk of periodontitis. The LE8 score and health factor score demonstrated critical mediating effects in the relationship between vitamin D and periodontitis. This study highlighted the intricate interplay among vitamin D, cardiovascular health (CVH), and periodontitis, providing insights into potential avenues for intervention and management.
Comparison of the Computational time of An Improved Quasi Equally Informative Subsets in Feature Selection
Authors: Safyan Abubakar . I. , Sani Zaharaddeen , Abubakar Mukhtar 
Published: January 2025

Abstract

This paper presents an enhanced feature selection method, the Improved Quasi Equally Informative Subsets in Feature Selection (QEISS), which addresses the computational inefficiencies of traditional approaches. By integrating Extreme Learning Machines (ELM) with the Non-dominated Sorting Genetic Algorithm II (NSGA-II), the improved method achieves faster execution times without sacrificing accuracy. The study introduces both a filter-based and wrapper-based QEISS variant, demonstrating consistent reductions in computational time across various high-dimensional datasets from the UCI repository. The method provides a balance between feature relevance, redundancy, subset size, and classification accuracy, marking a significant advancement in multi-objective feature selection.
Economic and environmental impacts of commercial milk formula in Indonesia: Estimates and comparisons using the Cost of Not Breastfeeding, Green Feeding, and Mothers’ Milk Tools
Authors: Septiani Nabila Nur , Pramono Andini , Nguyen Tuan Thanh , Mathisen Roger , Smith Julie 
Published: January 2025

Abstract

Background: Sales of commercial milk formula products (CMF) are rising rapidly. This study aims to analyse the key economic and environmental impacts CMF feeding in Indonesia.
Methods: We assessed the economic and environmental impacts of CMF in Indonesia in 2020 using the Mothers’ Milk Tool (MMT), the Green Feeding Tool (GFT) and the Cost of Not Breastfeeding Tool (CONBF). We compared estimated values from these tools and assessed them against calculations using Euromonitor data on CMF retail sales in Indonesia.
Results: In 2020, according to the MMT, women in Indonesia produced around 455 million litres of breastmilk for infants aged <6 months, which had an estimated monetary value of US$45.5 billion. The MMT and GFT shows substantial economic losses from displacement of breastfeeding in Indonesia; 62-96 million litres of breastmilk were lost in 2020 compared to the biologically feasible potential. The GFT tool calculates a carbon footprint of 214-272 million kg of CO2 eq. and a water footprint of 92,460 million litres. The CONBF estimates that the annual cost to families of purchasing CMF for infants aged <24 months was US$598.6 million. By comparison, Euromonitor retail sales data suggests that in 2020, the retail value of sales of CMF products targeting this age group was around US$2.25 billion. Euromonitor also reports 27,200 tonnes of CMF products targeting infants <6 months were sold in Indonesia in 2020. We calculate a carbon footprint from these sales of 299-381 million kg CO2 eq. and a water footprint of 129,064 million litres, considerably higher than the GFT estimate.
Conclusions: Breastfeeding's economic importance to Indonesia far surpasses the retail value of CMF sales. Displacing breastfeeding has high but largely undocumented economic and environmental costs. Economic losses are higher when measured as a food resource than when measured as health costs, lost lives, or cognition losses. Environmental impacts that are estimated using sales data are considerably higher than from using survey data. Our results expose a critical gap in national statistics, and a renewed imperative to recognise the milk women provide through breastfeeding as an economically valuable, healthy and sustainable national resource in Indonesia.
Efficacy and safety of finerenone in non-diabetic CKD patients: a single-center, real-world, retrospective study
Authors: Li Yu , Feng Jiaxing , Guo Xiaodan , Zhang Wusijie , Yang Ting , Guan Tianjun , Xu Bo 
Published: January 2025

Abstract

Background
Finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, has shown promising efficacy and safety profiles in the management of chronic kidney disease (CKD) associated with type 2 diabetes mellitus (T2DM). However, the effectiveness and safety of finerenone on non-diabetic CKD patients require further investigation.
Methods
This retrospective, real-world study involved non-diabetic CKD patients from April 2023 to June 2024. Participants received finerenone alongside standard CKD treatment. Primary clinical results included changes in the urinary albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and serum potassium (sK+) levels. The data were collected initially and during follow-ups at 1, 3, 6, and 12 months.
Results
In total, 37 non-diabetic CKD patients were included in the population; 21 individuals (56.8%) were male, and the mean age was 48.84 ± 14.69 years. During the follow-up, there was a notable decrease in UACR, with a median reduction of 664.95 mg/g (IQR, 196.60-1226.70, P = 0.002). The baseline average eGFR was 70.80 ± 27.97 mL/min/1.73m2, with no notable alterations observed during the follow-up (P > 0.05). In terms of safety analysis, the sK + levels were within the 3.5–5.5 mmol/L range, with no significant difference from the baseline (P > 0.05). No patients discontinued treatment or were hospitalized because of hyperkalemia.
Conclusion
Real-world practice indicates that finerenone is effective and safe for non-diabetic CKD patients, but further large-scale, prospective studies are needed to confirm these findings.
The First Landing of Flying Gurnard (Dactyloptena orientalis, Cuvier, 1829) at Ratnagiri, Maharashtra State, the Western Coast of India: An Ecological Overview
Authors: Jadhav Rakesh R. , Jadhav Diksha R. , Kazi Tousif G. , Kamble Sushil C. , Mirajkar Nilesh B. , Burte Rohit B. 
Published: January 2025

Abstract

Background
The present study aimed to report the first landing of the flying gurnard (Dactyloptena orientalis) at Ratnagiri, Maharashtra state, the western coast of India and to explore the ecological implications. Total seven specimens were collected from the local fishermen. The identification and the detailed study of the morphology of the fish and their ecological behaviour was completed in the laboratory. This study sought to fill a critical knowledge gap on the role of the species especially along the western coast of India since the species is not commonly observed.
Results
The landing of the flying gurnard in Ratnagiri was the first spotting of the species in the region. The average standard length (TL) of the fish was measured as 118.0 ± 0.41 mm. The findings of this study show that the landing of D. orientalis might be an indication of the current status of marine biodiversity and health, therefore more focused and specialized conservation measures are required for the species and the environment it inhabits. The study also pointed out the ecological significance of D. orientalis where it acts both as a predator and a prey in the marine food web as well as being capable of withstanding different environmental conditions.
Conclusion
This study contributed to the current information of D. orientalis particularly its function in the ecosystem of marine waters off Ratnagiri. Hence, the importance of constant observation and proper management practices arise from changes in the marine environment and flexibility of other organisms in the ecosystem to acclimatize to the changing conditions. The socio-economic effects on the fishing communities suggested that the integration of this species can modify fishing techniques and market trends, thus calling for sustainability concerns.
A Bibliometric Analysis of Research Funded by the German Academic Exchange Service (DAAD)
Authors: Osman Ismail Ragab 
Published: January 2025

Abstract

This study conducts a comprehensive bibliometric analysis of research papers funded by the German Academic Exchange Service (DAAD), utilizing data from the Web of Science (WoS) database as of April 1, 2024. Over the past four decades, DAAD-funded publications have significantly increased, reaching a total of 43,951 papers, with an annual growth rate of 16.67%. Initially modest, the number of publications surged post-2008, peaking in 2019, though a noticeable decline occurred after 2022. These publications span 7,570 journals, with notable contributions from journals like PLOS ONE and Scientific Reports. Key publishers such as Elsevier, Springer, and Wiley collectively account for a substantial portion of these outputs, underscoring a strategic preference for established outlets to maximize research impact. The study highlights the collaborative nature of DAAD-funded research, with 96% of papers being co-authored. German scholars dominate the authorship landscape, with significant contributions from leading institutions like the University of Rostock and the Technical University of Dresden. Leading the non-German universities benefiting from DAAD funding are the Russian Academy of Sciences and China's Chinese Academy of Sciences. The citation analysis reveals a considerable impact, with an average of 26.9 citations per paper and a total of 1,182,972 citations. International collaborations are prevalent, involving 181 countries, with the United States, China, and England being prominent partners. Research areas span 151 domains, with prominent clusters in chemistry, physics, materials science, and environmental sciences. Top author keywords such as climate change, taxonomy, morphology, phylogeny, cytotoxicity, and nanoparticles illustrate the diversity and specialization across disciplines. This analysis provides valuable insights into the scope, impact, and collaborative dynamics of research supported by DAAD, emphasizing its significant contribution to global academic advancement.
GBR using PTFEE membranes
Authors: Arllati Sinan , Syka Kreshnik 
Published: January 2025

Abstract

Guided Bone Regeneration (GBR) is a well-established technique used to augment bone volume in edentulous areas, thereby facilitating successful dental implant placement. One critical component of GBR is the use of barrier membranes that prevent soft tissue invasion into the defect site, thus creating a space that allows for bone regeneration. In this case report, we explore the use of Porcine Trabecular Free-Edge (PTFEE) membranes in GBR to treat a bone-deficient edentulous site in the posterior maxilla. The combination of PTFEE membranes and a mixture of autogenous bone, allograft, and xenograft materials provided favorable outcomes, enabling successful implant placement.
Multi Institutional Study on Awareness of Oral Cancer among Final Year Bangladeshi Dental Students and Intern Doctors
Authors: Sadat S. M. Anwar , Jabeen Afsana , Mim Khadiza Akter , Benzadid Shadly , Rita Sufia Nasrin , Khandker Nazmul Hasan , Gain Sumonto Kumar , Rahman Sabrina Binte , Huq Aminul , Zaman Farhana , Uddin Kamal , Alam Morshed , Mahmud Manjur E , Shaheen Amir , Rinku Shaikh Ahmed , Shaikh Mushfiq Hasan , Nabi Mohammad Hayatun , Reza Selim , Zaman Asad Uz , Islam Md. Tajul 
Published: January 2025

Abstract

Background: Oral cancer is widely recognized as a global health concern, with an aggressive nature and high mortality rates, especially in Southeast Asia where risk factors like betel quid and tobacco use are common. Although early detection can greatly improve prognosis, limited data exists on the knowledge, attitudes, and practices (KAP) of dental students and interns in Bangladesh regarding oral cancer prevention. This study aimed to assess these aspects among future dental practitioners.
Materials and Methods: A cross-sectional, questionnaire-based survey was conducted from January to March 2023 among final-year dental students and intern doctors from multiple institutions in Bangladesh. The survey utilized a 35-item questionnaire covering demographics, knowledge, practices, and attitudes toward oral cancer prevention.
Results: A total of 335 participants completed the survey. Approximately 79.1% demonstrated good knowledge of oral cancer; however, only 10.6% identified all risk factors. Furthermore, 60% exhibited poor preventive practices, with just 24.1% regularly screening patients. Attitudes were predominantly unfavorable, with 88.1% lacking confidence in screening activities. Age and gender were significantly associated with practice and attitude scores, with older and male participants scoring higher (P < 0.05).
Conclusion: The findings reveal substantial gaps in the KAP of Bangladeshi dental students and interns concerning oral cancer prevention. Addressing these gaps through curriculum enhancements, including early and practical training in cancer detection, could better prepare future practitioners for effective oral cancer management and prevention.
Oxygenation Status, Prehospital Communication, and Mode of Transportation for Critically Ill Patients: A Cross-Sectional Study in Addis Ababa Hospitals
Authors: Birhane Mayete Endale 
Published: January 2025

Abstract

Background
The prevalence of critical illness is increasing, posing a time-sensitive challenge to healthcare systems globally. Management of critically ill patients in emergency settings is highly dependent on prehospital care provision. Therefore, this study aimed to assess clinical profile of critically ill patients' oxygen saturation status, mode of transportation and prehospital communication upon arrival at the emergency department.
Methods
A prospective cross-sectional study was conducted at two large Addis Ababa governmental hospitals from August 20 to October 20/2023; 202 patients were recruited via convenient technique. The data were collected using a structured questionnaire which was obtained from the previous study, and analyzed using chi-square test and simple descriptive statistics such as frequencies, percentages, and means by SPSS version 27 software. The result has been explained in sentences, graphs, and tables.
Results
Among 202 study participants, the pattern of prehospital communication and hypoxia were 34/202 (16.8%) and 174/202 (86%) respectively. Ambulance usage was 94/202 (46%), with no statistically significant relationship between mode of arrival and oxygenation status.
Conclusion and Recommendation
This study highlights the inadequacy of prehospital activation and airway management emphasizing the need for real-time care and prearrival notification to optimize patient outcomes. The evidence of this paper indicated an urge for the Ministry of Health to implement well-equipped emergency medical care systems that ensure advanced resuscitation at the scene and during ambulance transfers and facilitate central prehospital communication to activate the accepting team.
Preparation and evaluation of risperidone slow-release injectable microspheres using chitosan
Authors: Latifi Parisa , Jahanshahi Amirali , Jamalara Aysan , Jammanesh Arezou , Alizadegan Dorsa 
Published: January 2025

Abstract

The aim of this study was preparation and evaluation of parenteral chitosan microspheres for sustained release of risperidone. Risperidone, a second-generation antipsychotic, is an effective in the treatment of schizophrenia and has a low incidence of adverse effect. Sustained release microsphere due to ascertain levels of drug in plasma, reduced toxicity and improving the efficacy of the drug. This study is done to consider the effect of four independent variables including, the drug to polymer ratio, TPP concentration, stirring speed and stirring time on the four dependent variables including, encapsulation efficiency, drug loading, particle size and the extent of initial burst in vitro release. In this study chitosan microspheres containing risperidone carried out by double emulsification/ solvent evaporation with two-step solidification process. The microspheres have been analyzed for their shape, size and surface characteristics. Interactions inside microspheres were investigated by differential scanning calorimetry and FTIR. In the following encapsulation efficiency, drug loading and burst release was investigated. The optimized formulation showed a narrow size distribution with an average of 115 ± 2 µm. The SEM image showed that microsphere was round in shape and discrete. The DSC analysis indicated the conversion of drug from crystalline state to molecular state in the optimized lyophilized formulation. FTIR analysis showed no changes in the chemical structure of risperidone in formulation. The in vitro release profile exhibited 92.3% drug release over 21 days in the sink condition.
Esketamine Treatment Trajectory of Patients with Treatment-Resistant Depression in the Mid and Long-Term Run: Data from REAL-ESK Study Group
Authors: Rosso Gianluca , d’Andrea Giacomo , Barlati Stefano , Di Nicola Marco , Andriola Ileana , Marcatili Matteo , Martiadis Vassilis , Olivola Miriam , Di Mauro Stefania , Di Salvo Gabriele , De Fazio Pasquale , Clerici Massimo , Dell’Osso Bernardo Maria , Vita Antonio , Di Lorenzo Giorgio , Pettorruso Mauro , Martinotti Giovanni , Maina Giuseppe 
Published: January 2025

Introduction/Objective:
Data on long-term treatment with Esketamine Nasal Spray (ESKNS)
in real-world patients with treatment resistant depression (TRD) is scarce. The primary aim of the
study is to evaluate the effectiveness and tolerability of ESK-NS treatment at 6 and 12-month follow-ups.

Methods:
This is part of an observational, retrospective, multicentric Italian study (REAL-ESK study).
Subjects for the present study underwent psychiatric assessments after 6 and 12 months from the start
of ESK-NS treatment. Repeated measures analysis of variance (ANOVA) was used to assess changes
in continuous variables, such as scores on psychometric scales from baseline to follow-up time points.

Results:
Of 63 patients who maintained ESK-NS treatment for at least 6 months, 48 were responders
or remitters (76.2%). Among 15 non-responders at 6 months, 4 significantly improved at 12-month
follow-up. At least one side effect was reported by 71.8% of subjects with a 6-month follow-up assessment.
An overall reduction of side effects was noticed as treatment progressed (42% of patients
who continued the treatment reported side effects at 12 months). The most common side effects were
sedation (31.7%) and dissociation (28.6%) during ESK-NS sessions. Only 2 patients discontinued
ESK-NS for tolerability reasons.

Conclusion:
The results support the effectiveness and safety of esketamine in the mid and long-term
treatment of TRD patients. The late clinical response of a subgroup of patients represents a novel finding.
Data needs to be confirmed in larger samples and longer observation periods.
Potential of Nanoparticle Based Antimicrobial Drug Repurposing to Efficiently Target Alzheimer’s: A Concise Update on Evidence-based Research and Challenges Ahead
Authors: Biswal Biswabhusan , Satapathy Bhabani Sankar , Mishra Abhishek , Maharana Laxmidhar , Pattnaik Snigdha 
Published: January 2025

Abstract:
Repurposing of drugs through nanocarriers (NCs) based platforms has been a recent trend
in drug delivery research. Various routine drugs are now being repurposed to treat challenging neurodegenerative
disorders including Alzheimer disease (AD). AD, at present is one of the challenging
neurodegenerative disorders characterized by extracellular accumulation of amyloid-β and intracellular
accumulations of neurofibrillary tangles. In spite of catchy progress in drug development, effective
treatment outcome in AD patients is far-fetched dream. Out of several proposed hypothesis in
the development and progression of AD, potential role of microorganisms causing dementia and AD
cannot be ruled out. Several recent researches have been documented a clear correlation in between
microbial infection and neuronal damage leading to progression of AD. Thus, antimicrobial drugs
repurposing has been emerged as alternate, potential, cost-effective strategy to check progression of
AD. Further, for efficient delivery of antimicrobial drugs to brain tissue, novel NCs based platforms
are the preferred option to bypass blood-brain barrier. Several polymeric and lipid NCs have been
extensively studied over the past years to improve antimicrobial drug delivery to brain. The present
review encompasses various repurposing strategy of antimicrobial drugs delivered through various
NCs to target AD. Evidence-based research outcome compiled from authentic database like Scopus,
PubMed, Web of science have been pooled to provide an updated review. Side by side some light has
been thrown on the practical problems faced by nanodrug carriers during technology transfer.