bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIPGEN: a randomized, multicentre phase III study using intramuscular PLacenta-eXpanded stromal cells therapy for recovery following hip fracture arthroplasty
Authors: Winkler Tobias , Costa Matthew L. , Ofir Racheli , Parolini Ornella , Geissler Sven , Volk Hans-Dieter , Eder Christian ,   On behalf of the HIPGEN Author Consortium
Published: April 2022

AimsThe aim of the HIPGEN consortium is to develop the first cell therapy product for hip fracture patients using PLacental-eXpanded (PLX-PAD) stromal cells.MethodsHIPGEN is a multicentre, multinational, randomized, double-blind, placebo-controlled trial. A total of 240 patients aged 60 to 90 years with low-energy femoral neck fractures (FNF) will be allocated to two arms and receive an intramuscular injection of either 150 × 106PLX-PAD cells or placebo into the medial gluteal muscle after direct lateral implantation of total or hemi hip arthroplasty. Patients will be followed for two years. The primary endpoint is the Short Physical Performance Battery (SPPB) at week 26. Secondary and exploratory endpoints include morphological parameters (lean body mass), functional parameters (abduction and handgrip strength, symmetry in gait, weightbearing), all-cause mortality rate and patient-reported outcome measures (Lower Limb Measure, EuroQol five-dimension questionnaire). Immunological biomarker and in vitro studies will be performed to analyze the PLX-PAD mechanism of action. A sample size of 240 subjects was calculated providing 88% power for the detection of a 1 SPPB point treatment effect for a two-sided test with an α level of 5%.ConclusionThe HIPGEN study assesses the efficacy, safety, and tolerability of intramuscular PLX-PAD administration for the treatment of muscle injury following arthroplasty for hip fracture. It is the first phase III study to investigate the effect of an allogeneic cell therapy on improved mobilization after hip fracture, an aspect which is in sore need of addressing for the improvement in standard of care treatment for patients with FNF. Cite this article: Bone Jt Open 2022;3(4):340–347.
Low-cross-talk and multi-channel heterogeneous 13-core four-LP mode fiber with a high refractive index ring and a trench
Authors: Shao Pengshuai , Li Shuguang , Li Jianshe , Meng Xiaojian , Guo Ying , Li Zenghui , Wang Luyao 
Published: April 2022

We propose a heterogeneous 13-core few-mode fiber, which is characterized by the combination of a high refractive index ring and a trench. All cores of the optical fiber can stably transmit

L
P

01

,

L
P

11

,

L
P

21

, and

L
P

02

modes in the C

+

L band through structural optimization and numerical analysis. The effective refractive index difference of the

L
P

21

and

L
P

02

modes reaches

2

×

10

−
3

, which is conducive to the independent transmission of modes. The trench can effectively suppress the inter-core cross talk below

−

50

d
B

/

k
m

at 1550 nm. The proposed few-mode multi-core fiber is conducive to solving the long-distance signal transmission problem of large capacity and low cross talk in future optical communication systems.
Signs of left atrial disease and 10-year risk of atrial fibrillation
Authors: Uhe Tobias , Stegmann Tina , Langhammer Romy , Dagres Nikolaos , Laufs Ulrich , Wachter Rolf 
Published: April 2022

BackgroundThe contribution of left atrial disease and excessive supraventricular ectopic activity (ESVEA) to the risk for incident atrial fibrillation (AF) is incompletely understood.ObjectiveTo analyse the ten-year risk to develop AF in patients with cardiovascular risk factors and to define the impact of parameters of left atrial disease and ESVEA on AF risk.Methods148 patients from the Diast-CHF trial with at least one cardiovascular risk factor and free of AF at baseline were followed for 10 years. Left atrial disease was defined as left atrial volume index (LAVI) >35 ml/m2, P-terminal force in lead V1(PTFV1) >4000 ms*μV or elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) >250 pg/ml. We analyzed the association of these parameters and ESVEA (either >720 premature atrial contractions (PAC) or one atrial run >20 beats per day) on AF-free survival.ResultsAfter ten years, AF was newly detected in twelve patients (13.4%) with signs of left atrial disease and two patients (3.4%) without signs of left atrial disease (p = 0.04). LAVI (p = 0.005), ESVEA (p = 0.016) and NT-proBNP (p = 0.010) were significantly associated with AF-free survival in univariate analysis. A combined Cox model of left atrial disease parameters showed associations for NT-proBNP (HR 3.56; 95%CI 1.33–5.31; p = 0.04) and PAC (HR 2.66; 95%CI 1.25–10.15; p = 0.01) but not for LAVI or PTFV1with AF-free survival.ConclusionThe risk for AF is higher in patients with cardiovascular risk factors and signs of left atrial disease. NT-proBNP and premature atrial contractions independently predict AF-free survival. The role of excessive supraventricular ectopic activity for the assessment of AF risk may be underestimated and requires further study.
Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors
Authors: Seki Yasufumi , Ichihara Atsuhiro 
Published: April 2022

Introduction
Growth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, we attempted to clarify the characteristics of GHD in unoperated patients with NFPT.

Materials and methods
We retrospectively reviewed adult patients with non-functioning pituitary adenoma (NFPA) and Rathke’s cyst who underwent preoperative GH-releasing peptide-2 (GHRP-2) tests from January 2013 to December 2016. We investigated the association between peak GH response to GHRP-2 and background characteristics.

Results
Among 104 patients (85 NFPA and 19 Rathke’s cysts), 45 (43%) presented severe GHD, as diagnosed using GHRP-2 tests. Body mass index (β = -0.210, P = 0.007), free thyroxine (β = 0.440, P < 0.001), and tumor height (β = -0.254, P < 0.001) were significant variables for determining the peak GH response to GHRP-2 in multiple regression analyses. Overweight (odds ratio, 3.86; 95% confidence interval, 1.02–14.66) was significantly associated with severe GHD after adjustment for age, sex, creatinine, free thyroxine, tumor height and clinical diagnosis. The regression slopes between tumor height and peak GH response to GHRP-2 significantly differed between overweight patients and non-overweight individuals, as determined by analysis of covariance (P = 0.040). In the 48 patients who underwent postoperative GHRP-2 tests, severe postoperative GHD was significantly more common in overweight patients than non-overweight individuals (100% vs. 48%, P < 0.001).

Conclusion
We observed a negative synergistic effect between overweight and tumor size on GH secretion in patients with NFPTs, indicating that GH provocation tests for diagnosing underestimated GHD could be considered in overweight unoperated patients with large NFPTs.
Cooperative transportation: realizing the promises of robotic networks using a tailored software/hardware architecture
Authors: Ebel Henrik , Eberhard Peter 
Published: April 2022

Abstract
With cooperative transportation, the paper looks at a demanding problem from distributed robotics. At its heart, the proposed transportation scheme uses distributed model predictive control. Yet, distributed control alone does not suffice to solve the task. Thus, also distributed organization, a custom software architecture, simulation, and custom robotic hardware are dealt with, bridging the gap between distributed control theory and practical robotics. The robots are enabled to transport arbitrarily-shaped objects, automatically adapting to changing circumstances and numbers of robots.
Rollout event-triggered control: reconciling event- and time-triggered control
Authors: Wildhagen Stefan , Dürr Frank , Allgöwer Frank 
Published: April 2022

Abstract
Event-triggered control (ETC) and time-triggered control (TTC), the classical concepts to determine the transmission instants for networked control systems, each come with drawbacks: It is difficult to tune ETC such that a certain bandwidth is respected, whereas TTC cannot adapt the sampling interval to the current state of the control system. In this article, we provide an overview over rollout ETC, a method aimed at reconciling the advantages of ETC and TTC. We unite two variants of rollout ETC under a common framework and present conditions for convergence and compliance with a predefined bandwidth limit. Furthermore, we demonstrate that rollout ETC satisfies a performance bound and that it allows for a very flexible transmission scheduling similar to classical ETC. The mentioned beneficial properties are illustrated through extensive numerical simulations.
The ChristologicalPerichōrēsisand Dance
Authors: Hikota Riyako Cecilia 
Published: April 2022

AbstractIn order to take the physical and incorporeal dimension of dance seriously in the context of Christian theology, we propose that it should be the neglected ChristologicalPerichōrēsis(as well as concepts and ideas surrounding it) rather than the TrinitarianPerichōrēsisthat is historically and traditionally relevant as a source of a dialogue between Christian theology and dance. First, we propose that the guiding metaphor should beChrist as dancer, historical examples of which already exist unlike with the notion of the Trinity as dance. Then, we look at St Maximus the Confessor’s Christocentric cosmology. With the human being understood as a “microcosm” of body–soul(spirit) unity placed at the center of the entire creation, his Christocentric cosmology could be a potential source for enhancing a dialogue between Christian theology and dance, while helping us overcome the dualistic separation between the body and the spirit and consequently between nature and culture.
Gesellschaftsrecht im Spiegel seiner Habilitationsschriften
Authors: Fleischer Holger 
Published: April 2022

Zusammenfassung

Habilitationsschriften haben wesentlich zum wissenschaftlichen Fortschritt im Gesellschaftsrecht beigetragen. Der vorliegende Beitrag erschließt erstmals den enormen Korpus einschlägiger Arbeiten aus den letzten acht Jahrzehnten. Zugleich geht er auf ihre Besonderheiten ein und analysiert ihre thematische Spannbreite, ihre methodischen Zugriffe und ihre Rezeption in Rechtsprechung und Rechtslehre.
A busca por direitos humanos
Authors: Soares Evanway Sellberg 
Published: April 2022

Devido à crescente influência religiosa no discurso político contra minorias sexuais e de identidade de gênero, este artigo busca apresentar alternativas religiosas de valorização dessas identidades, seus processos de formação e meios de ação no meio público. Para isso, é realizada a análise de dados obtidos em observação participante na Igreja da Comunidade Metropolitana a partir da perspectiva de Habermas e Honneth, contribuindo para o debate sobre a atualidade da Teoria Crítica como ferramenta de análise. Fica constatado que as ações da denominação no espaço público na luta por direitos LGBT está baseada num processo de luta por reconhecimento social, gerando uma disputa não somente discursiva, mas também em ações políticas no espaço público, visando a transformação da sociedade. Ao fazer isso, a denominação se torna um braço religioso no movimento LGBT mais amplo, dialogando tanto com outras denominações, quanto com a sociedade de modo mais amplo.
Wood ash versus expanded clay aggregate as internal curing water reservoirs in high performance concrete
Authors: Rodríguez-Álvaro Roberto , González-Fonteboa Belén , Seara-Paz Sindy , Tenza-Abril Antonio José 
Published: April 2022

AbstractThe performances of expanded clay aggregate and wood ash as internal curing water reservoirs were studied in the mortar phase of a hypothetical high performance concrete with a low water-to-binder ratio. The two materials substituted the 15 and 30% of the sand volume. Two different binders, Portland cement and high-volume fly ash blended cement, were used. The compressive strength and the volume stability of the mortars in sealed and air-drying conditions were studied. Furthermore, the desorption capacity of the internal curing water reservoirs and the internal humidity inside the mortars during the first days after casting were analysed. The results shown that the reduction in the self-desiccation shrinkage was higher when the expanded clay aggregate was used, even in air-drying curing conditions, due to its higher desorption capacity in low-relative-humidity environments in comparison to that of the wood ash. However, wood ash had a stronger beneficial effect on early age autogenous shrinkage without significantly increasing the drying shrinkage. The two alternative aggregates influenced the strength moderately. Considering the technical, economic, and environmental implications of using the two lightweight aggregates, wood ash is recommended.
Superdiseminadores durante la pandemia del SARS-CoV-2 en Cartagena, Colombia
Authors: Coronell-Rodríguez Wilfrido , Arteta-Acosta Cindy , Dueñas-Castell Carmelo 
Published: April 2022

Introducción: la diseminación de agentes infecciosos en una población puede ocurrir de forma homogénea o heterogénea. El SARSCoV-2 tiene transmisión heterogénea por los superdiseminadores (SD, individuos con ciertas características que transmiten la infección a un 80% de la población expuesta).Objetivos: describir las características de los SD en los primeros casos de COVID-19 en Cartagena, Colombia. Metodología: estudio de vigilancia epidemiológica realizado entre el 25 de febrero y el 20 de abril del 2020 por el Comité de infecciones de la clínica Gestión Salud y el Departamento Administrativo Distrital de Salud, a casos sospechosos, confirmados por T-PCR para SARSCoV-2 y contactos estrechos de casos confirmados de COVID-19.Resultados: en 30 días se confirmaron dos pacientes SD, 21 casos secundarios (10 y 11, por cada paciente) y dos terciarios. El 1er SD inició síntomas 48 horas después de la exposición, fue hospitalizado al séptimo día de iniciado los síntomas y falleció a las 72 horas dehospitalización. El 2do SD hospitalizado por cetoacidosis diabética, con posterior hallazgo de anosmia y disgeusia, permaneció en UCI unmes. De los casos secundarios, el 9,5% (2/21) fueron hospitalizados en UCI, 47% (10/21) en sala general y 42% (9/21) estuvieron en cuarentena.El 61% (14/23) de los contagiados fue personal de la salud.Conclusiones: los SD son importantes en la dinámica de transmisión de infecciones. El no reconocimiento o el diagnóstico errado en un paciente con infección por SARS-CoV-2, junto con la transferencia interhospitalaria, son las principales causas de la generación de un número desproporcionado de casos secundarios.
Reuniones virtuales de morbilidad y mortalidad en Colombia:
Authors: Flórez Paula Camila , Vega-Peña Neil Valentín 
Published: April 2022

Introducción: la pandemia por la Covid-19 modificó la educación médica con estrategias apoyadas en lataformas virtuales y en escenarios no convencionales. Un ejemplo de ello son las reuniones de morbilidad y mortalidad (M y M). El objetivo de este estudio es describir las características de las M y M virtuales en las instituciones de práctica de los residentes de cirugía general en Colombia; así como la percepción de los participantes sobre su funcionamiento, comparado con las M y M presenciales o tradicionales.
Método: estudio observacional y descriptivo realizado en 21 institucioneshospitalarias de práctica, de 17 programas de cirugía general de Colombia en donde operan M y M virtuales. Se obtuvo información sobre sus objetivos, características operativas y alcances. Con encuestas autodiligenciadas se investigó, además, la percepción de los participantes acerca de su utilidad y funcionamiento, producto del cambio a la virtualidad. Participaron 82 residentes y 65 docentes de diferentes programas de posgrado de cirugía general del país.
Resultados: las M y M virtuales se ejecutan en el 53 % de los sitios de práctica de los residentes de Colombia, con el predominio en las instituciones privadas. Si bien hay diferencias en su organización, persiste el modelo tradicional de M y M: objetivos, estructura y alcances. Hay una duración mayor de las reuniones, se realizan en horarios no convencionales, con una percepción de un menor nivel cadémico. Se respira un menor ambiente de hostilidad con el uso de la virtualidad.
Conclusión: las reuniones de morbilidad y mortalidad se realizan en un escenario de virtualidad. Su funcionamiento es similar a las reuniones presenciales y su ejecución ofrece oportunidades de mejoraen términos de forma y fondo.
Governando a atenção: sobre as implicações ético- políticas da testagem psicológica
Authors: Pessoa Pimentel César , Do Amaral Gama Santos Marcus Vinícius 
Published: April 2022

Este artigo busca, enquanto trabalho de reflexão, investigar processos associados à modulação da percepção dos sujeitos nas sociedades contemporâneas por meio do exame histórico da constituição e uso de testes de atenção concentrada, principalmente dos testes de Toulouse-Piéron. Para isso, recorrese aos conceitos de governamentalidade de Michel Foucault e Nikolas Rose, e de móbiles-mutáveis de Bruno Latour. Considera-se as alterações dos regimes de atenção a partir das narrativas de: Kurt Danziger acerca da constituição do conceito de inteligência; Jonathan Crary acerca da crise da capacidade

e síntese perceptiva do indivíduo moderno;
e Lev Manovich acerca da constituição do
corpo enquanto domínio informacional nas
sociedades contemporâneas. Aplicando esse conjunto teórico ao campo da testagem psicológica, começamos por esclarecer a emergência dos testes de atenção na França, focando anoção de “biocracia”, de Toulouse. Em seguida, examinamos teses, dissertações e artigos
contemporâneos acerca do teste, verificando
deslocamentos em seu uso, envolvendo faixa
etária, correlatos neurocientíficos e motivação do seu uso. Concluímos que esses deslocamentos apontam para a emergência de modos
de modular a atenção segundo as demandas
de eficácia e iniciativa proeminentes nas sociedades contemporâneas.
Satisfacción laboral y personalidad en trabajadores de salud pública de Pueyrredón (San Luis, Argentina)
Authors: Hauser María Paz , García Horacio Daniel 
Published: April 2022

El objetivo de este estudio fue indagar la existencia de la relación entre satisfacción laboral y personalidad en trabajadores de salud pública. Se trabajó con una muestra probabilística de ciento diez trabajadores del sector de salud pública del departamento Pueyrredón, de la provincia de San Luis, Argentina. Fueron evaluados mediante: a) cuestionario ad hoc; b) una adaptación del Big Five Inventory (Castro Solano y Casullo, 2001) y c) sub escala trabajo q-les-q (The World Health Organization Quality of life assessment [whoqol], 1993). La investigación estuvo guiada por el deseo de conocer características sociodemográficas, medir satisfacción laboral e identificar estilos de personalidad.
Problemas epistemológicos de la psicología contemporánea
Authors: Cappelletti Andrés 
Published: April 2022

En primer lugar, este trabajo expone las dificultades que se encuentran al intentar realizar un análisis reduccionista de la complejidad del mundo del conocimiento científico; se afirma que para una consideración integral del conocimiento científico y tecnológico contemporáneo es necesario un estudio que se dirija a su multidimensionalidad. En segundo lugar, se abordan los problemas epistemológicos de la psicología en lo que se refiere a la fragmentación del campo disciplinar, al problema de la cientificidad de la disciplina y a los problemas vinculados a las relaciones entre la psicología y la filosofía. Finalmente, se destaca la necesidad de retornar a una meditación sobre el alma-psykhé, si la pretensión es contribuir a una crítica dirigida a la constitución de la psicología como tecnociencia reguladora de los comportamientos.
Conductas sexuales de riesgo y comunicación sobre sexualidad entre padres e hijos universitarios
Authors: Uribe Rodríguez Ana Fernanda , Castellanos Barreto Jennifer , Cabán Huertas Marlene 
Published: April 2022

El artículo presenta los resultados de una investigación que tuvo como objetivo la caracterización de una muestra de jóvenes universitarios en relación con las conductas de riesgo el ámbito sexual y reproductivo y la comunicación entre padres e hijos. Se trabajó con un método de investigación transversal con diseño descriptivo, participaron 473 estudiantes universitarios de tres ciudades de Colombia, entre hombres y mujeres. Resultados: los universitarios inician su vida sexual en promedio a los 13.24 años, evidenciándose el escaso uso del preservativo y altos índices de riesgo. La comunicación es un recurso fundamental en los procesos de intercambios de vivencias, de ahí la importancia de las dinámicas familiares en el logro de una salud sexual y reproductiva sana y responsable.
Características psicoemocionales y adaptativas de niñas entre 7 a 14 años que practican gimnasia rítmica
Authors: Montoya Arenas David Andres 
Published: April 2022

El objetivo de esta investigación fue establecer las características psicoemocionales y adaptativas de niñas entre 7 a 14 años que practican gimnasia rítmica, en la ciudad de Medellín, Colombia, de la comuna 13, en el barrio San Javier, sector afectado por la violencia, el narcotráfico y grupos al margen de la ley, para ello se aplicó la Escala Multimodal de la Conducta a 41 niñas que hacen parte del proyecto Escuelas Populares del Deporte, del Instituto de Deporte y Recreación de Medellín, Resultados: en el autoinforme no se reportó síntomas de ansiedad, ni depresión, ni atipicidad en la mayoría de la población, en la escala adaptativa hay bajos niveles de autoconfianza y en las niñas con poco tiempo de entrenamiento se encontró reporte de conductas hostiles hacia los profesores, los padres informan que no hay síntomas de hiperactividad, ni problemas atencionales significativos, y si indicadores altos de compañerismo y adecuadas habilidades sociales y que la práctica deportiva en el tiempo contribuye a no mostrar síntomas de atipicidad ni problemas conductuales y sin importar el tiempo de entrenamiento reportan síntomas de somatización, los profesores en lo adaptativo reportan que las niñas de menos de un año de entrenamiento, registran como normal las habilidades sociales y como indicador clínico las habilidades de estudio, contrario a las de más de un año de entrenamiento.
On negativity and subjectivity: Kierkegaard
Authors: Silva Arango María Juliana 
Published: April 2022

Kierkegaard’s Irony was an operation by which commonly accepted customs and historical practices could be criticized, by promoting wisdom through delivering no positive philosophical doctrine or theory to others who claimed to know something. This was his ‘Socratic task.’ Similar to Socrates, Kierkegaard focused his intellectual efforts on understanding what it meant to be a human and how to pursue a life worth of living. To his view, truly existing individuals, who obeyed the natural human desire to know, would embrace the negativity of uncertainty and take responsibility for their personal views. His Christian understanding of God, as related to subjectivity, was what he meant to defend by applying Irony. When confronting the Clergy of the Copenhagen of his time, Kierkegaard learnt the political consequences to the commitment to Socrates’ method in the way he applied it to his modern setting.