bluuebunny/crossref_metadata_2025_split huggingface dataset:
LOCAL DEVELOPMENT IN COMPUTERISATION ON THE EXAMPLE OF OPOLE CITY HALL
Authors: BOHDAN ANNA 
Published: November 2022

Commune authorities take measures aiming at ensuring development of e-administration at the municipal level in accordance with the requirements of the fast-changing legal environment and on an ongoing basis. In contacts with petitioners of commune offices, it especially concerns ensuring smooth and effective service provision via electronic means and communicating by electronic means of communication.
The subject matter of this article is an answer to the question about the level of computerisation of the Opole City Hall in contacts with petitioners and city residents. The analysis covers solutions within the scope of providing services via electronic means and electronic form of one-way communication between the City Hall and residents: the public information bulletin website and the city website. This allows for presenting the adopted model of e-administration within the scope of providing e-services and communicating with petitioners of the office and city residents.
The Dietary Intake of Children Aged 6 to 59 Months and their Hemoglobin Concentration, Central Highland Ethiopia, Community Based Baseline Data
Authors: Ferede Abebe , Belachew Tefera , Abera Muluemebet 
Published: November 2022

Iron deficiency anemia (IDA) in young children has lacked attention and priority in developing countries where illiteracy is the greatest encumbrance in the community. This study aimed to assess the hemoglobin level (Hgb) and linear growth of children for baseline data for optional intervention.
Methods: Community-based cross-sectional study was carried out among women and their paired children. A multistage sampling method was involved in selecting the study area and 1012 mothers/caregivers and their paired children. Interviewed, blood samples, and anthropometry data were collected and analyzed using IBM SPSS Statistics version 21. Statistical significance was declared at P<0.05
Results: All mothers with their paired children participated in the study. A high proportion (76.7%, n=776) of women aged 20 to 35 years and 505 (59.9%) of women had an awareness of IDA. The mean Hgb concentration of children was 128.23g/L (+ 17.3), and 184 (18.4 %) of the children had anemia, which was higher (24.1%) among age groups 6 -23 months. The highest proportion (42.1%, n = 426) of the children had stunted growth (Height for Age [HFA] Z score < -2 Standard Division [SD]) and a very high prevalence (24.6%, n = 251) of wasting (Weight for Height [WFH] Z score >-1SD) verified among children. The age of children is positively associated with Hgb level (β = 0.172, CI=0.01, 0.33). For a one-month increase in age, Hgb concentration increased by 0.170 mg/del.
Conclusions: A very high growth defect and moderate IDA were observed among study subjects. Attentive intervention approaches are important in self-monitoring and a routine modification of used household foods in complementary feed with efficient iron nutrients to reduce growth defects.
Prevalence of rheumatoid arthritis and diagnostic validity of a prediction score, in patients visiting orthropedic clinics in the Madinah region of Saudi Arabia: a retrospective cross-sectional study
Authors: Mir Shabir Ahmad , Noor Mamdooh , Manzar Md Dilshad , Alshehri Bader , Alaidarous Mohammed , Dukhyil Abdul Aziz Bin , Banawas Saeed , Madkhali Yahya , Jahan Sadaf , Kashoo Faizan Z. , Iqbal Danish , Zia Qamar , Alsagaby Suliman A. , ALDosari Sahar 
Published: November 2022

Introduction
In Saudi Arabia, the epidemiology of rheumatoid arthritis (RA) is not well studied and is marked by inconsistencies in clinical diagnosis. Therefore, in this study, we explored the prevalence, clinical characteristics, and diagnostic validity of a prediction score based upon disease markers in orthropedic clinics’ patients in the Madinah region of Saudi Arabia.

Method
The clinical data for this retrospective cross-sectional study were retrieved from the database registry of orthopedic clinics in selected hospitals of the Medinah province of Saudi Arabia. Sociodemographic features, disease markers and the clinical characteristics were collected for a period of 6 months, from December 1, 2020, to May 31, 2021. The prediction score was generated from the sum of disease markers, coded as dichotomous variables.

Results
The total sample size of our study was 401. The prevalence of RA in the study subjects (n = 401) was 14.46% (n = 58). Among RA patients, the majority were females (60.3%). Painful joints (69%) and swollen joints (51.7%) were the most common clinical complaints among RA patients. RA patients suffered from arthritis (51.7%) and experienced fatigue (46.6%), weight loss (44.8%), and loss of appetite (41.4%). Diabetes (55.2%) was the most common comorbidity in the RA patients. The sensitivity and specificity of the prediction score at the criterion score of 2.5 were 67.3% and 63.0%, respectively. The area under the curve was 0.69 (95% CI [0.62–0.76]).

Conclusion
There was a moderately high prevalence of RA in patients visiting the orthropedic clinics of the selected hospitals of Madinah region of Saudi Arabia. The diagnostic validity of the prediction score, though promising, was slightly lower than the acceptable range.
Zero Till Water Use Efficient Rabi Sorghum (Sorghum bicolour L. Moench), an Effective Alternative to Water Guzzling Summer Rice (Oryza sativa), under Changing Climatic Scenario
Authors: Ghorai Asesh Kumar 
Published: November 2022

As temperature rises, the yields of food and cash crops in South Asia are expected to decline, putting pressure on food security in the region. India, home to 1.4 billion people, is ranked 101 out of 116 countries in the Global Hunger Index, indicating a serious problem. Scientists and researchers project that a 2.5 to 4.90C increase in temperature across the country could lead to a decrease of 41%-52% in the wheat yield, and 32%-40% in rice. Under changing climate conditions, hybrid sorghum is an effective solution for food security, which can withstand high temperatures and grow with less water over water guzzling summer rice. It has versatile utility as food grains, feed, fodder, and an important feedstock for first-generation biofuel or bioethanol production. Zero till hybrid sorghum cultivars CSH 14, CSH 16, and CSH 23 were sown after Kharif rice in jute-rice-Rabi sorghum sequence, in winter, on 1st January 2010. The crop matured with 52.5 cm irrigation water at 120 days (30th April) and consumed 7 irrigations, 7.5 cm each. The highest sorghum grain yield was obtained from cv. CSH 14 i.e., 6.5 tonnes/ha. Its water productivity was high, 808 litre water/kg grain whereas for summer rice with the same productivity (6.5t/ha) the water productivity was low, 2308 litre water/kg rice grain (irrigation requirement 150 cm). Thus, with the same water, the area under sorghum will be thrice over summer rice. Gross return from hybrid sorghum was Rs.193050/ha over Rs. 132600/ha from summer rice. Rabi sorghum saved 65% (97.5 cm/ha) of irrigation water which is drawn from groundwater only. From 6.5 tons of sorghum grain, approximately 2470 litre of ethanol can be produced/ha which is used as biofuel. Replacement of summer rice by profitable drought-resistant Rabi sorghum will ensure food security under changing climatic scenarios and maintain a sustainable groundwater position in traditional rice growing belts.
Impact of NICRA on Cropping Pattern and Extent of Adoption of Climate Resilient Practices on Farmers
Authors: Phanisri P. S. M. , Kumar J. Hemantha , Kumar K. Ravi , Chaitanya V. , Suneetha W. Jessie , Srinivas D. , Nagaraju D. , Reddy R. Uma , Prasad J. V. 
Published: November 2022

Agriculture is extremely vulnerable to climate change and short duration and higher temperatures eventually reduced yields of crops white encouraging weed and pest proliferation. the changes in precipitation patterns increase the likelihood of short- run crop failure and long run production decline Climate resilient technologies are promising tool to guard a farming system from climatic variations. National Initiative on Climate Resilient Agriculture (NICRA) has demonstrated, and promoted application of climate resilient technologies in most vulnerable 100 districts. Krishi Vigyan Kendra, Wyra received NICRA project in the year 2010- 2011 to 2110 - 2011. Many climate resilient technologies were briefed to the farmers in the selected villages. The farmers distinguished the demonstrated technologies to the farmers were adopted with ease. Majority of the NICRA beneficiaries have high adoption to the climate resilient technologies while few of non beneficiaries adopted the technologies.
Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals
Authors: Pirruccello James P. , Lin Honghuang , Khurshid Shaan , Nekoui Mahan , Weng Lu-Chen , Vasan Ramachandran S. , Isselbacher Eric M. , Benjamin Emelia J. , Lubitz Steven A. , Lindsay Mark E. , Ellinor Patrick T. 
Published: November 2022

ImportanceAscending thoracic aortic disease is an important cause of sudden death in the US, yet most aortic aneurysms are identified incidentally.ObjectiveTo develop and validate a clinical score to estimate ascending aortic diameter.Design, Setting, and ParticipantsUsing an ongoing magnetic resonance imaging substudy of the UK Biobank cohort study, which had enrolled participants from 2006 through 2010, score derivation was performed in 30 018 participants and internal validation in an additional 6681. External validation was performed in 1367 participants from the Framingham Heart Study (FHS) offspring cohort who had undergone computed tomography from 2002 through 2005, and in 50 768 individuals who had undergone transthoracic echocardiography in the Community Care Cohort Project, a retrospective hospital-based cohort of longitudinal primary care patients in the Mass General Brigham (MGB) network between 2001-2018.ExposuresDemographic and clinical variables (11 covariates that would not independently prompt thoracic imaging).Main Outcomes and MeasuresAscending aortic diameter was modeled with hierarchical group least absolute shrinkage and selection operator (LASSO) regression. Correlation between estimated and measured diameter and performance for identifying diameter 4.0 cm or greater were assessed.ResultsThe 30 018-participant training cohort (52% women), were a median age of 65.1 years (IQR, 58.6-70.6 years). The mean (SD) ascending aortic diameter was 3.04 (0.31) cm for women and 3.32 (0.34) cm for men. A score to estimate ascending aortic diameter explained 28.2% of the variance in aortic diameter in the UK Biobank validation cohort (95% CI, 26.4%-30.0%), 30.8% in the FHS cohort (95% CI, 26.8%-34.9%), and 32.6% in the MGB cohort (95% CI, 31.9%-33.2%). For detecting individuals with an ascending aortic diameter of 4 cm or greater, the score had an area under the receiver operator characteristic curve of 0.770 (95% CI, 0.737-0.803) in the UK Biobank, 0.813 (95% CI, 0.772-0.854) in the FHS, and 0.766 (95% CI, 0.757-0.774) in the MGB cohorts, although the model significantly overestimated or underestimated aortic diameter in external validation. Using a fixed-score threshold of 3.537, 9.7 people in UK Biobank, 1.8 in the FHS, and 4.6 in the MGB cohorts would need imaging to confirm 1 individual with an ascending aortic diameter of 4 cm or greater. The sensitivity at that threshold was 8.9% in the UK Biobank, 11.3% in the FHS, and 18.8% in the MGB cohorts, with specificities of 98.1%, 99.2%, and 96.2%, respectively.Conclusions and RelevanceA prediction model based on common clinically available data was derived and validated to predict ascending aortic diameter. Further research is needed to optimize the prediction model and to determine whether its use is associated with improved outcomes.
An Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms
Authors: Warren Bobby G. , Barrett Aaron , Graves Amanda , King Carly , Turner Nicholas A. , Anderson Deverick J. 
Published: November 2022

ImportanceEnvironmental contamination is a source of transmission between patients, health care practitioners, and other stakeholders in the acute care setting.ObjectiveTo compare the efficacy of an enhanced daily disinfection strategy vs standard disinfection in acute care hospital rooms.Design, Setting, and ParticipantsThis randomized clinical trial (RCT) was conducted in acute care hospital rooms at Duke University Hospital in Durham, North Carolina, from November 2021 to March 2022. Rooms were occupied by patients with contact precautions. Room surfaces (bed rails, overbed table, and in-room sink) were divided into 2 sides (right vs left), allowing each room to serve as its own control. Each side was randomized 1:1 to the intervention group or control group.InterventionsThe intervention was a quaternary ammonium, salt-based, 24-hour continuously active germicidal wipe. It was applied in addition to routine disinfection for the intervention group. The control group received no intervention beyond routine disinfection.Main Outcomes and MeasuresThe primary outcome was the total contamination, measured in colony-forming units (CFUs) on the bed rails, overbed table, and sink on study day 1. The secondary outcomes were the proportion of sample areas with positive test results for clinically important pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and carbapenem-resistant Enterobacteriaceae; the similarity in baseline contamination between sample area sides on study day 0 before application of the intervention, and the proportion of sample areas with removed UV luminescent gel on study day 1.ResultsA total of 50 study rooms occupied by 50 unique patients (median [IQR] age, 61 [45-69] years; 26 men [52%]) with contact precautions were enrolled. Of these patients, 41 (82%) were actively receiving antibiotics, 39 (78%) were bedridden, and 28 (56%) had active infections with study-defined clinically important pathogens. On study day 1, the median (IQR) total CFUs for the intervention group was lower than that for the control group (3561 [1292-7602] CFUs vs 5219 [1540-12 364] CFUs; P = .002). On study day 1, the intervention side was less frequently contaminated with patient-associated clinically important pathogens compared with the control side of the room (4 [14%] vs 11 [39%]; P = .04).Conclusions and RelevanceResults of this RCT demonstrated that a quaternary ammonium, salt-based, 24-hour continuously active germicidal wipe decreased the environmental bioburden in acute care hospital rooms compared with routine disinfection. The findings warrant large-scale RCTs to determine whether enhanced daily disinfection strategies can decrease patient acquisition and adverse patient outcomes.Trial RegistrationClinicalTrials.gov Identifier: NCT05560321
Recent Advances in Calcium‐Based Anticancer Nanomaterials Exploiting Calcium Overload to Trigger Cell Apoptosis
Authors: Xiao Yupeng , Li Zhao , Bianco Alberto , Ma Baojin 
Published: November 2022

AbstractCalcium ion is vital for the regulation of many cellular functions and serves as a second messenger in the signal transduction pathways. Once the intracellular Ca2+ level exceeds the tolerance of cells (called Ca2+ overload), oxidative stress, mitochondrial damage, and cell/mitochondria apoptosis happen. Therefore, Ca2+ overload has started to be deeply exploited as a new strategy for cancer therapy due to its high efficiency and satisfactory safety. This review aims to highlight the recent development of Ca2+‐based nanomaterials (such as Ca3(PO4)2, CaCO3, CaO2, CaH2, CaS, and others) able to trigger intracellular Ca2+ overload and apoptosis in cancer therapy. The intracellular mechanisms of varied Ca2+‐based nanomaterials and the different types of strategies to enhance Ca2+ overload are discussed in detail. Moreover, the design of more efficient Ca2+ overload‐mediated cancer therapies is prospected mainly based on 1) the enhanced cellular uptake by surface modification and morphology optimization of nanomaterials, 2) the accelerated Ca2+ release from nanomaterials by increasing the intracellular H+ level and by photothermal effect, and 3) the overload maintenance by Ca2+ efflux inhibition, Ca2+ influx promotion, or promoting Ca2+ release from the endoplasmic reticulum.
Lipoplex‐Functionalized Thin‐Film Surface Coating Based on Extracellular Matrix Components as Local Gene Delivery System to Control Osteogenic Stem Cell Differentiation
Authors: Husteden Catharina , Brito Barrera Yazmin A. , Tegtmeyer Sophia , Borges João , Giselbrecht Julia , Menzel Matthias , Langner Andreas , Mano João F. , Schmelzer Christian E. H. , Wölk Christian , Groth Thomas 
Published: November 2022

AbstractA gene‐activated surface coating is presented as a strategy to design smart biomaterials for bone tissue engineering. The thin‐film coating is based on polyelectrolyte multilayers composed of collagen I and chondroitin sulfate, two main biopolymers of the bone extracellular matrix, which are fabricated by layer‐by‐layer assembly. For further functionalization, DNA/lipid‐nanoparticles (lipoplexes) are incorporated into the multilayers. The polyelectrolyte multilayer fabrication and lipoplex deposition are analyzed by surface sensitive analytical methods that demonstrate successful thin‐film formation, fibrillar structuring of collagen, and homogenous embedding of lipoplexes. Culture of mesenchymal stem cells on the lipoplex functionalized multilayer results in excellent attachment and growth of them, and also, their ability to take up cargo like fluorescence‐labelled DNA from lipoplexes. The functionalization of the multilayer with lipoplexes encapsulating DNA encoding for transient expression of bone morphogenetic protein 2 induces osteogenic differentiation of mesenchymal stem cells, which is shown by mRNA quantification for osteogenic genes and histochemical staining. In summary, the novel gene‐functionalized and extracellular matrix mimicking multilayer composed of collagen I, chondroitin sulfate, and lipoplexes, represents a smart surface functionalization that holds great promise for tissue engineering constructs and implant coatings to promote regeneration of bone and other tissues.
A Review of Recent Progress on Collagen‐Based Biomaterials
Authors: Zheng Manhui , Wang Xuechuan , Chen Yining , Yue Ouyang , Bai Zhongxue , Cui Boqiang , Jiang Huie , Liu Xinhua 
Published: November 2022

AbstractSince the 2010s, the demand for healthcare models has exceeded the prevailing resources available due to the rapid increase in the aging population in China. However, a significant gap in development of biomedical materials remains, especially between China and the western developed countries. Collagen is the major protein of the extracellular matrix (ECM) and has been extensively applied in medical fields. Collagen‐based biomaterials (CBBs) are used to prepare dressings and dermal substitutes, surgical sutures, plasma substitutes, tissue‐engineered scaffolds, and drug delivery systems; this is attributed to their exceptional biocompatibility, biodegradability, hypoimmunogenicity, and coordination between collagen hosts and tissues. This review provides thorough strides in CBB structures, crosslinking and forming technologies, and real‐world applications. First, the natural origin and specific structures of animal‐derived collagen and non‐animal‐derived collagen are introduced and compared. Second, crosslinking methods and forming technologies of CBBs across the board are discussed. Third, several examples are considered to demonstrate the practical biomedical use of CBBs and highlight cautionary notes. Finally, the underlying development directions of CBBs from an interdisciplinary perspective are outlined. This review aims to provide comprehensive mechanisms by which collagen can be uniquely and practically used as advanced biomaterial, hence providing options for augmenting its development in China.
Memristive Field‐Programmable Analog Arrays for Analog Computing
Authors: Li Yunning , Song Wenhao , Wang Zhongrui , Jiang Hao , Yan Peng , Lin Peng , Li Can , Rao Mingyi , Barnell Mark , Wu Qing , Ganguli Sabyasachi , Roy Ajit K. , Xia Qiangfei , Yang J. Joshua 
Published: November 2022

AbstractThe increasing interests in analog computing nowadays call for multipurpose analog computing platforms with reconfigurability. The advancement of analog computing, enabled by novel electronic elements like memristors, has shown its potential to sustain the exponential growth of computing demand in the new era of analog data deluge. Here, a platform of a memristive field‐programmable analog array (memFPAA) is experimentally demonstrated with memristive devices serving as a variety of core analog elements and CMOS components as peripheral circuits. The memFPAA is reconfigured to implement a first‐order band pass filter, an audio equalizer, and an acoustic mixed frequency classifier, as application examples. The memFPAA, featured with programmable analog memristors, memristive routing networks, and memristive vector‐matrix multipliers, opens opportunities for fast prototyping analog designs as well as efficient analog applications in signal processing and neuromorphic computing.
3D Printed Thick Reduced Graphene Oxide: Manganese Oxide/Carbon Nanotube Hybrid Electrode with Highly Ordered Microstructures for Supercapacitors
Authors: Gao Yuqi , Ding Junjun 
Published: November 2022

AbstractHigh capacitance and good rate performance supercapacitors are needed to power sensors and miniaturized electrical devices. Thick electrodes are promising to increase the mass loading of active materials in supercapacitors, but the 3D geometries and microstructures in thick electrodes still hinder the development with high electron and ion exchange rate and accessible active sites. The scaffold 3D electrodes of reduced graphene oxide:manganese oxide/carbon nanotube (rGO:MnOx/CNT) are manufactured by material extrusion 3D printing (ME3DP), where the mass ratio of rGO to MnOx/CNT composites, thickness, and mass loading per unit area are controllable. The increasing amount of MnOx/CNT composites boosts the areal capacitance. Although the rate capability decays fast with the increasing of MnOx/CNT, it remains stable at different thicknesses (1.2, 1.6, and 2 mm). 2 mm thick rGO:MnOx/CNT (weight ratio 5:3) electrode exhibits an area capacitance of 302.13 mF cm−2 at a current density of 0.5 mA cm−2, due to the highly ordered rGO networks. Compared to the casted electrodes, the microstructures in the 3D printed electrode contribute to lower resistances for the charge and ion transportation.