bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galantamine: A Review Update
Authors: Kaur Jaspreet , Melkani Indu , Singh Ajeet Pal , Singh Amar Pal , Bala Kiran 
Published: July 2022

Galantamine, like nor-belladine, is a benzazepine. Galanthus and other plants of the Amaryllidaceae are the most common sources of it. Galantamine is used to combat the muscle effects of gallamine triethiodide and tubocurarine by acting as a cholinesterase inhibitor. The review reveals the protective effects of galantamine on the functions and integrity of the liver, brain and memory impairment. Various independent studies have shown anti-Alzheimer, antioxidant, antidiabetic and neuroprotective effect of galantamine. The current review highlights current knowledge and the health-promoting effects of a drug known as galantamine. This review summarizes the current state in the pharmacology of galantamine, focusing on its effects on tolerance, dosage, drug interactions and pharmacological studies in animal models.
Keywords: Galantamine, Pharmacology, Acetylcholinesterase inhibitor, Neuroprotective, Protective effect.
Development and In-Vitro Evaluation of Plantago ovata Based Rapid Disintegrating Tablets of Labetalol Hydrochloride
Authors: Dubey Abhay Kumar , Archana , 
Published: July 2022

Objectives: To avoid swallowing problems of conventional tablets and improved patient compliance Plantago Ovata based Labetalol HCl Rapid disintegrating tablets have been prepared. Methods: Six different (F1 to F6) batches of Labetalol HCl Rapid disintegrating tablets were developed by ‘direct compression method’ using Plantago ovata as a natural super-disintegrating agent. The formulated RDT were tested for angle of repose’, densities like tapped and bulk density, Hausner’s ratio, Carr’s index like pre-compression parameters and for thickness, weight variation or weight uniformity, tablet hardness, % drug content or content uniformity, water absorption ratio’, time require for wetting of tablets’ means wetting time, in-vitro drug disintegration time and in-vitro drug dissolution studies under post-compression parameters of evaluation. Results: It was found that the all the results of these pre-compression and post-compression parameters comply with official standards. The drug release was determined using dissolution media of pH 6.8 phosphate buffer through in-vitro dissolution of drug. This study showed that a rapid drug release by prepared tablets. The optimized formulation F6 showed higher water absorption ratio`, lower wetting time, minimum in-vitro disintegration time’ and higher drug release amongst all the formulations. The F6 formulation was considered the best among all formulations. Conclusion: The prepared rapid disintegrating tablets shows rapid onset of action by quick drug release, minimize side effects and enhanced patient compliance. These prepared tablets containing selective alpha-1 and non-selective beta adrenergic antagonist’ drug candidate Labetalol HCl, will be very useful in the treatment of high blood pressure with enhanced bioavailability.
Keywords: Rapid disintegrating tablets, Labetalol Hydrochloride, Bioavailability Enhancement, Natural Superdisintegrant, Plantago Ovata, High Blood Pressure, RDT, Patient Compliance
Comparative Effects of Cashew Nut, Leaf and Stem Bark (Anacardium Occidentale L.) on Hyperglycemia and Associated Abnormalities in Streptozotocin-Induced Diabetic Rats
Authors: Ajao Folasade Omobolanle , Akanmu Oluwatosin , Iyedupe Marcus Olaoye 
Published: July 2022

Background: Medicinal plants are used as alternative therapy for diabetes. This study investigated comparative effects of methanolic extracts of Anacardium occidentale (linn) nut, leaf and stem bark on hyperglycemia and associated abnormalities in streptozotocin-induced diabetic rats.
Methods: Ninety male Wistar albino rats weighing (200±20g) were used and diabetes was induced by single intraperitoneal injection of streptozotocin (50mg/kgb.wt). The rats were allotted into 9 groups, 10rats/group. Group I: (non-diabetic); Group II: (diabetic untreated); Groups: III & IV: diabetic rats received 100mg/kgb.wt& 200mg/kgb.wt nut extract; Groups: V & VI: diabetic rats received 100mg/kgb.wt& 200mg/kgb.wt leaves extract; VII & VIII were diabetic rats received 100mg/kgb.wt& 200mg/kgb.wt stem bark extract and Group IX: diabetic rats received 2mg/kgb.wt p.o glimepirides for 4weeks. Daily food and water intakes were recorded; weekly body weight and blood glucose levels were measured throughout the experiment. The animals were sacrificed on the last day and fasting plasma blood glucose was withdrawn for biochemical parameters estimation.
Results: Fasting plasma blood glucose, triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), aspartate aminotransferase (AST), alanine aminotransferase, alkaline (ALT), aminotransferase (ALP), urea, uric acid, creatinine, malondialdehydes (MDA) and water intake levels were significantly (p<0.01, 0.05) reduced in the extracts treated groups. However, High density lipoprotein- cholesterol (HDL-C), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), body weight and food intake levels were significantly (p<0.01, 0.05) increased in the extracts treated groups.
Conclusion: Anacardium occidentale parts posses anti-diabetic properties. The nut has extreme therapeutic efficacy and could be used as alternative therapy for diabetes.
Keywords: Anacardium occidentale, Hyperglycemia, Lipid profiles, Antioxidants, Kidney function.
Holarrhena antidysenterica in Inflammatory Bowel Disease: a potential review
Authors: Bala Kiran , Melkani Indu , Singh Ajeet Pal , Singh Amar Pal , Kaur Jaspreet 
Published: July 2022

Holarrhena antidysenterica belongs to the Apocynaceae family and is generally known as kurchi in Hindi. It is a small deciduous tree found in arid woods throughout the world including India. H. Antidysenterica is commonly used in Indian traditional medicine to treat Inflammatory Bowel disease, dysentery, diarrhoea and worms in the intestines. Plant parts like bark are useful in antimicrobial, anti-inflammatory and analgesic treatments, amoebiasis, chronic bronchitis, boils, and ulcers. The Phytoconstituents found in the plant ergosterol, flavonoids, phenolic acids, resins, saponins, steroidal alkaloids, coumarins, tannins and triterpenoids. Anti-amnesic, anti-diabetic, antibacterial action, anti-inflammatory, anti-diarrhoeal, antioxidant/free radical activity , radical scavenging, diuretic, anti-amoebic, anthelmintic and anti-microbial effects are found as pharmacological properties of Holarrhena antidysenterica. H. antidysenterica bark contains alkaloids the most important of which is the steroidal alkaloid conessine which is the major therapeutic constituent. Conarrhimine, Conimine, Conamine, Conessidine, Isoconessimine, Dimethyl Conkurchine and Holarrhimine are among the various alkaloids studied. The bark also includes gum, resin, tannin, lupeol and the digitenol glycoside Holadysone in addition to alkaloids. Bark of Holarrhena antidysenterica is used to treat malaria, chest infections, asthma, bronchopneumonia, stomach disorders, dyspepsia, diarrhoea and dysentery.
Keywords: HA- Holarrhena antidysenterica, IBD- Inflammatory Bowel Disease, Collitus
Granulocyte colony stimulating factor (GCSF) protected in ovarian tissues against ischemia-reperfusion injury
Authors: Aktaş Ayfer , Aşır Fırat , Başaran Süreyya Özdemir , Kaplan Özge , Ermiş Işılay Sezen , Deveci Engin 
Published: July 2022

Ovarian torsion is an important reproductive gynecological emergency in daily life and physiology. Granulocyte colony stimulating factor (G-CSF) is a glycoprotein capable of hematopoietic development and successfully used in the treatment of congenital granulocytopenia. In our study, we aimed to investigate protective effects of G-CSF on ovarian ischemia reperfusion (IR) immunohistochemically. Four groups were used. In control group, abdomen was opened and closed with the surgical protocol. The rats in the G-CSF group were given 100 µg/kg G-CSF subcutaneously before the IR and the abdomen was surgically opened and closed. 3-h of ischemia was and then 3-h reperfusion was induced in the ischemia-reperfusion (I/R) group. In the IR+G-CSF group, 100 µg/kg G-CSF was given before the procedure and IR was performed. At the end of the experiment, ovarian tissues were fixed in 10% formalin and then processed for routine paraffin tissue protocol. Normal ovarian histology was observed in the control and G-CSF groups. In the IR group, vascular dilatations, hemorrhage and increased inflammation were observed. In the I/R+G-CSF group, pathology in seen IR was decreased. IL-6 expression was mainly negative in control and G-CSF groups. Positive IL-6 immune reaction was observed in the granulosa cells and stromal area. In the I/R+G-CSF group, IL-6 expression was significantly decreased in ovarian follicular structures and in the stromal area compared to the I/R group. In conclusion, G-CSF reduced vascular dilatation and inflammation in the ovarian IR model and promoted ovarian folliculogenesis.
Keywords: Ovary, Ischemia/reperfusion, G-CSF, Azan, IL-6, Immunohistochemistry
Nanoparticle of Telmisartan and Polyvinylpyrrolidone K-30: Characterization and Dissolution Study
Authors: Fadhila Muthia , Wahyuni Rina , Sari Yeni Novita , Octavia Maria Dona , Lestari Meliati Dwi 
Published: July 2022

Background: Telmisartan (TEL) is an orally active nonpeptide angiotensin II antagonist drug. The drug acts on a subtype of AT1 receptors, which serves to cope with high blood pressure (hypertension). TEL is a class II Biopharmaceutical Classification System (BCS), which is a drug that has low solubility in water and high permeability. Objectives: This study aims to determine the effect of the formation of TEL-PVP K-30 nanoparticles through the solvent drop grinding method on the characteristics of physicochemical properties and the rate of dissolution of TEL. Methods: Nanoparticles are made in 2 formulas, namely formula 1: 1 and formula 1: 2. Results: Characterization of the Particle Size Analyzer (PSA) was performed with the results of the formula 1:1 24nm, and the formula 1:2 35nm. X-ray Diffraction (XRD) analysis resulted from a decrease in the intensity of crystallinity degrees. Fourier Transform Infrared (FT-IR) Spectroscopy occurs wave number shift. Differential Scanning Calorimetry (DSC) decreases in melting point. The dissolution rate was carried out using a pH 7.5 phosphate tart medium. Conclusion: The result of the dissolution rate has increased by 3.3 times for formula 1:1 and 2.9 times for formula 1:2.
Keywords: Telmisartan; polyvinylpyrrolidone K-30; nanoparticles; and solvent drop grinding.
ANALISIS FISCAL POLICY TERHADAP PERTUMBUHAN EKONOMI DI PROVINSI ACEH
Authors: Murtala Murtala 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kebijakan fiskal dalam bentuk pajak dan belanja pegawai terhadap pertumbuhan ekonomi di Provinsi Aceh. Jenis data yang digunakan adalah data sekunder dengan menggunakan variabel pajak, belanja pegawai dan pertumbuhan ekonomi dengan menggunakan model regresi. Hasil penelitian menunjukkan kebijakan fiskal dalam bentuk pajak berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi di Provinsi Aceh. Kebijakan fiskal dalam bentukbelanja pegawai berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi di Provinsi Aceh artinya semakin tinggi angka belanja pegawai maka akan menurunkan pertumbuhan ekonomi di Provinsi Aceh.Kebikalan fiskal baik pajak dan belanja pegawai berpengaruh terhadap pertumbuhan ekonomi di provinsi Aceh sebesar 81,8 persen dan sisanya sebesar 18,2 persen dipengaruhi oleh variabel lainnya diluar model penelitian ini.Diharapkan kepada pemerintah daerah dan pemerintah pusat agar dapat membantu dan mendorong kegiatan pertumbuhan ekonomi di provinsi Aceh, dengan tidak sembarangan menaikkan pajak dan belanja pegawai.
Negara, Politik Identitas, dan Makar: Pandangan Organisasi Massa Islam Tentang Makar dan Upaya Pencegahannya Melalui PERPPU Ormas
Authors: Hermawan Sulhani , Sidik Sidik 
Published: July 2022

The discourse of mass organization dismissal of Hizbut Tahrir Indonesia (HTI) by the government through the Government Regulation in Lieu of Law No. 2/2017 (Perppu), that now has been officially being the mass organization regulation, causes pro and contra.This article analyses the substance of the differencies of HTI, NU, and Muhammadiyah opinion about violant attack (makar) and Perppu as its rule to protect it. It also analyses the rationale and reason of their opinion. This article finds two points: First, HTI noted that their activities were not a violant attack but the religious proselytizing (dakwah) so that the dimissal act through Perppu, according to them, was not appropriate. Meanwhile, NU said that HTI activities were a violant attack and they supported itsdismissal through Perppu. Whereas Muhammadiyah argued that the contradiction toward national idology is a violant attack but it dimissal has to be constitutional. Second, based on the social dialectic theory, this article notes that the differencies of these mass organization opinion were influenced by their different conception on nation that internalized when they looked at the problem of violant attack and Perppu. According to the political identity theory, each mass organization brings religious knowledge identity that fitted together, especially concerning Perppu.

Diskursus terkait penonaktifan organisasi massa (ormas) Hizbut Tahrir Indonesia (HTI) oleh pemerintah melalui Peraturan Pemerintah Pengganti Undang-Undang No. 2 tahun 2017 (Perppu Ormas), yang kemudian disahkan menjadi UU Ormas, memunculkan pro-kontra. Artikel ini mengkaji bagaimana substansi perbedaan pandangan HTI, Nahdhatul Ulama (NU), dan Muhammadiyah (MU) tentang makar dan Perppu sebagai payung hukum pencegahannya. Lantas, apa sebenarnya yang melandasi perbedaan pandangan tersebut. Kajian ini menemukan beberapa hal. Pertama, HTI berpandangan bahwa aktivitas mereka bukan makar melainkan aktivitas dakwah sehingga pembubarannya melalui Perppu dinilai tidak beralasan. Sementara NU memandang aktivitas HTI adalah makar dan mendukung pembubarannya melalui Perppu. Adapun Muhammadiyah berpandangan bahwa yang bertentangan dengan ideologi negara adalah makar, tapi pencegahannya harus secara konstitusional. Kedua, merujuk pada teori dialektika sosial, perbedaan sikap masing-masing ormas dipengaruhi oleh pandangan mereka tentang konsepsi negara yang terinternalisasi dalam menyikapi persoalan makar dan pencegahannya melalui Perppu. Sementara berdasarkan teori politik identitas, masing-masing ormas mengusung identitas pemahaman keagamaan yang saling beririsan terkait Perppu.
O papel do enfermeiro na prevenção de doenças sexualmente transmissíveis junto aos adolescentes no contexto educacional
Authors: Freitas Bikterline Lana 
Published: July 2022

Existe um consenso entre os estudiosos sobre a adolescência: fase marcante, caracterizada por etapas decisivas e profundas mudanças físicas, psicológicas e comportamentais, que deixam o jovem susceptível a uma série de eventos nocivos e prejudiciais à sua vida, e consequências a curto e longo prazo que poderiam ser evitadas se a informação se antecipasse aos fatos. Sabe-se que o adolescente encontra-se em processo de construção de uma identidade própria, pois ainda não apresenta maturidade sexual e responsabilidade reprodutiva, sendo que os seus relacionamentos sexuais ocorrem mais para satisfazer os seus impulsos. Assim nesta pesquisa buscou entender o papel do enfermeiro na prevenção de doenças sexualmente transmissíveis e o resultado mostrou que o enfermeiro deve reformular o processo de trabalho a partir da criação de novos saberes.
Research on the processing method of multi-source heterogeneous data in the intelligent agriculture cloud platform
Authors: Gao Weimin , Zhong Jiaming , Liu Yichen 
Published: July 2022

Abstract
With the development of big data and blockchain technology, a large amount of multi-source heterogeneous data has been accumulated in the agricultural field by before, during and after production. Agricultural information service systems are often targeted at specific regions, specific applications and specific data resources. Due to the lack of effective analysis and refining, the conversion efficiency of data resources into useful information is too low, resulting in contradiction between the continuous enrichment of agricultural data resources and the relative lack of agricultural information services. Therefore, in view of the multi-source heterogeneous characteristics of agricultural data and the specific business needs of different agricultural scenarios, the intelligent processing method of agricultural data is analysed, and a heuristic algorithm based on K-Means limited clustering number is proposed to judge the accuracy of abnormal data processing. By inputting test sample data for testing, the algorithm has improved accuracy by nearly 30% compared to traditional K-Means.
Intensi Perilaku Berwisata Alam Pasca Vaksinasi Covid-19
Authors: Hakim Imam Nur , Eddyono Fauziah , Abdullah Syahfirin 
Published: July 2022

The Covid-19 pandemic has had a destructive impact that has changed Indonesia’s tourism sector. One of the changes is the shift in preferences and behavior of tourists who switch to natural destinations, especially after the Covid-19 vaccination. This study aims to determine the factors that can trigger the emergence of behavioral intentions for nature tourism after the Covid-19 vaccination, especially in DKI. Jakarta has the highest infection rate, cure, and recipient of the Covid-19 vaccine in Indonesia. This study empirically applies the theory of planned behavior (TPB) to 156 respondents. Using Structural Equation Modeling (SEM), data processing and analysis tests found four significant and one insignificant correlation. Attitudes and subjective norms significantly influence the intention of nature tourism after the Covid-19 vaccination. Even subjective norms empirically can also influence the emergence of attitudes and perceived behavioral control of nature tourism behavior. However, the perceived behavioral control of nature tourism behavior cannot trigger the emergence of the nature tourism behavioral intention of DKI. Jakarta even though they have been vaccinated.
Keywords: covid-19, theory of planned behavior (tpb), tourism, tourism behavioral intention, vaccine.
Desenvolvimento Motor em Crianças Praticantes de Ginástica Artística
Authors: Venâncio Patrícia Espíndola Mota , Fernandes Thaynara de Lima , Pessoa Caio Bueno , Silva Lyvia Pedra , Barbosa Dhennyffer Gonçalves , Teixeira Júnior Jairo , Santos Cláudia Gomes de Oliveira dos , Teixeira Cristina Gomes de Oliveira 
Published: July 2022

Objetivo: Identificar o desenvolvimento motor em crianças praticantes de ginástica e comparar as avaliações das crianças analisadas entre avaliadores. Métodos: A amostra foi composta por 28 crianças com idade de 6 anos e com mais de 6 meses de prática de ginástica artística e 3 avaliadores. Foi aplicado o teste de Gallahue DL e Ozmun JC (2003) que avaliou o equilíbrio, pegada, corrida, salto horizontal, rolamento, galope e saltitos. Resultados: Pode-se apontar que para a avaliação de equilíbrio apresentou a média 46,4% no estágio 3. No pegar, a média 35,7% no estágio 4; Saltito, no estágio 3, e média de 42,9%; rolamento, estágio 2, e média de 42,9%, levando em consideração que a faixa etária das crianças para esse teste seria de 4 a 6 anos de idade e deveriam estar acima do estágio 2 para um bom resultado. Conclusão: Concluiu-se que que os níveis de desenvolvimento motor, na maioria das crianças, foram positivos, estando acima do estágio descrito por Gallahue DL e Ozmun JC (2003) nos testes de equilíbrio, pegar, saltitos, salto horizontal e corrida. E quanto a comparação das avaliações entre avaliadores, houve diferença significativa em dois testes avaliados, corrida e salto horizontal.
L’énonciation à l’épreuve de l’« I.A. ». Qu’est-ce- qu’énoncer veut dire ?
Authors: Pignier Nicole 
Published: July 2022

Comment, les « deepfakes » peuvent-ils faire sens s’ils « signifient » sans « faire signe » ? C’est du point de vue de l’énonciation ou plutôt de la coénonciation, c’est-à-dire de l’échange entre énonciateurs et co-énonciateurs, ceux qui perçoivent, accueillent ces énoncés et se les approprient que nous questionnons les deepfakes. Si les images ou vidéos fabriquées automatiquement à partir de synthèse d’images existantes sont dites « fausses », cela pose la question suivante : les images énoncées par les humains peuvent-elles dire la vérité ? Les deepfakes défient l’énonciation, mettent à l’épreuve le « Faire signe » en le simulant, ils nous invitent à questionner le lien à l’Autre fondateur de la coénonciation.
ANALISIS UJI BEDA DIGITAL MARKETING, BRAND AWARENESS TERHADAP KEPUTUSAN PEMBELIAN PRODUK FASHION (DALAM NEGERI VS LUAR NEGERI) DI MASA PANDEMI
Authors: Azis Yunia , Destiani Mia Mustika 
Published: July 2022

The high rate of layoffs during the pandemic caused purchasing power to drop drastically so that people prioritized buying primary needs over secondary needs such as fashion. This condition forces fashion entrepreneurs to switch to marketing their products using digital media so that existing brand awareness remains attached to consumers' memories. Fashion products originating from within the country have always competed with foreign products, so it is necessary to research whether there is a difference in consumer purchasing decisions for domestic and foreign products during the pandemic. The study was conducted to compare purchasing decisions during the pandemic, especially domestic and foreign fashion products through digital marketing and brand awareness.
The research method used is descriptive and different test, using 2 fashion products as a comparison. The population of this study are women aged 20-40 years and often make transactions through online shops. Respondents were 30 people, the research instrument was a questionnaire. Validity and reliability were used to test the feasibility of the questionnaire, homogeneity and normality tests were used to test the sample, while the Independent sample t-test was used to compare the difference in the mean of the two different samples.
This study obtained the results that in terms of digital marketing, brand awareness, and the decision to purchase foreign products were better developed than domestic products.
PENGARUH KEPEMILIKAN MANAJERIAL, KOMITE AUDIT, LEVERAGE DAN UKURAN PERUSAHAAN TERHADAP KINERJA KEUANGAN
Authors: Sari Tri diah , Titisari Kartika Hendra , Nurlaela Siti 
Published: July 2022

Â Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh kepemilikan manajerial, komite audit, leverage dan ukuran perusahaan terhadap kinerja keuangan yang diukur dengan Return On Asset (ROA). Penelitian ini merupakan penelitian kuantitatif. Teknik pengambilan sampel menggunakan metode purposive sampling. Jumlah sampel dalam penelitian ini adalah 36 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2015-2018. Analisis statistik yang digunakan pada penelitian ini adalah analisis regresi linear berganda. Hasil penelitian ini menunjukan bahwa kepemilikan manajerial, komite audit dan leverage berpengaruh terhadap kinerja keuangan. Sedangkan ukuran perusahaan tidak berpengaruh terhadap kinerja keuanganKata kunci : Ukuran Perusahaan, Leverage, Komite Audit, Kepemilikan Manajerial, Kinerja Keuangan