bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute thermal stress elicits interactions between gene expression and alternative splicing in a fish of conservation concern
Authors: Thorstensen Matt J. , Turko Andy J. , Heath Daniel D. , Jeffries Ken M. , Pitcher Trevor E. 
Published: June 2022

ABSTRACTTranscriptomic research provides a mechanistic understanding of an organism's response to environmental challenges such as increasing temperatures, which can provide key insights into the threats posed by thermal challenges associated with urbanization and climate change. Differential gene expression and alternative splicing are two elements of the transcriptomic stress response that may work in tandem, but relatively few studies have investigated these interactions in fishes of conservation concern. We studied the imperilled redside dace (Clinostomus elongatus) as thermal stress is hypothesized to be an important cause of population declines. We tested the hypothesis that gene expression–splicing interactions contribute to the thermal stress response. Wild fish exposed to acute thermal stress were compared with both handling controls and fish sampled directly from a river. Liver tissue was sampled to study the transcriptomic stress response. With a gene set enrichment analysis, we found that thermally stressed fish showed a transcriptional response related to transcription regulation and responses to unfolded proteins, and alternatively spliced genes related to gene expression regulation and metabolism. One splicing factor, prpf38b, was upregulated in the thermally stressed group compared with the other treatments. This splicing factor may have a role in the Jun/AP-1 cellular stress response, a pathway with wide-ranging and context-dependent effects. Given large gene interaction networks and the context-dependent nature of transcriptional responses, our results highlight the importance of understanding interactions between gene expression and splicing for understanding transcriptomic responses to thermal stress. Our results also reveal transcriptional pathways that can inform conservation breeding, translocation and reintroduction programs for redside dace and other imperilled species by identifying appropriate source populations.
Grammatical awareness and language performance: examining gendered differences among Saudi EFL (English as a foreign language) learners
Authors: Alharbi Ayed T 
Published: June 2022

Background: Despite the many studies that have been conducted on the learners of English as a foreign language (EFL) regarding grammar ability in various contexts, some gaps are still unbridged and need researching. Therefore, this study addresses the research gap in the Saudi context concerning the grammatical competence of Saudi EFL (English as foreign language) learners. Methods: This study described the Saudi EFL learners’ level of awareness in developing grammatical forms. It also assessed Saudi EFL students' level of performance in grammar learning. Finally, it quantitatively explored what, if any, gendered differences exist in the grammar acquisition of Saudi EFL learners. The study employed descriptive and inferential statistics to analyze the data. The study sample comprised 50 Saudi EFL students out of the population of 120 students enrolled in EFL programs at Qassim University, Saudi Arabia with sample size being determined using online sampling calculator Raosoft. Results: The results of the present study show that the Saudi EFL learners manifest a favorable level of awareness in developing grammatical forms while they still not having attained mastery of English grammar. Results also indicate that grammatical competence and level of awareness are more advanced among the Saudi EFL female learners compared to their male counterparts. Conclusions: The outcomes of this research imply that Saudi EFL learners have sufficient performance in grammar learning but need further nurturance. Implications of this study will serve as a basis for English language learning development interventions in the benefit of the students.
Outcomes in intervention research on snakebite envenomation: a systematic review
Authors: Bhaumik Soumyadeep , Beri Deepti , Tyagi Jyoti , Clarke Mike , Sharma Sanjib Kumar , Williamson Paula R , Jagnoor Jagnoor 
Published: June 2022

Introduction: A core outcome set (COS) is a minimal list of consensus outcomes that should be used in all intervention research in a specific domain. COS enhance the ability to undertake meaningful comparisons and to understand the benefits or harms of different treatments. A first step in developing a COS is to identify outcomes that have been used previously. We did this global systematic review to provide the foundation for development of a region-specific COS for snakebite envenomation. Methods: We searched 15 electronic databases, eight trial registries, and reference lists of included studies to identify reports of relevant trials, protocols, registry records and systematic reviews. We extracted verbatim data on outcomes, their definitions, measures, and time-points. Outcomes were classified as per an existing outcome taxonomy, and we identified unique outcomes based on similarities in the definition and measurement of the verbatim outcomes. Results: We included 107 records for 97 studies which met our inclusion criteria. These reported 538 outcomes, with a wide variety of outcome measures, definitions, and time points for measurement. We consolidated these into 88 unique outcomes, which we classified into core areas of mortality (1, 1.14 %), life impact (6, 6.82%), resource use (15, 17.05%), adverse events (7, 7.95%), physiological/clinical (51, 57.95%), and composite (8, 9.09%) outcomes. The types of outcomes varied by the type of intervention, and by geographic region. Only 15 of the 97 trials (17.04%) listed Patient Related Outcome Measures (PROMS). Conclusion: Trials evaluating interventions for snakebite demonstrate heterogeneity on outcomes and often omit important information related to outcome measurement (definitions, instruments, and time points). Developing high quality, region-specific COS for snakebite could inform the design of future trials and improve outcome reporting. Measurement of PROMS, resource use and life impact outcomes in trials on snakebite remains a gap.
Collaborative faculty development transforms evaluation at a school of osteopathic medicine: an exploratory grounded theory study
Authors: Bustamante-Helfrich Blandine , Santa Maria Emma , Bradley Jessica , Warden Douglas , Sengupta Anamika , Phillips-Madson Robyn , Ungaretti Toni 
Published: June 2022

Background:Faculty development (FD) initiatives for medical educators must keep pace with educators’ expanding roles and responsibilities in the 21stcentury to effectively support and guide professional growth. Successful initiatives will be comprehensive and systematic, rather than episodic. Our research explores the impact of a collaborative, individualized, and focused FD program. The purpose of this pilot study is: (1) to describe the innovative design and implementation of the incipient FD program at University of the Incarnate Word School of Osteopathic Medicine (UIWSOM), San Antonio, Texas; and (2) to present insights from a preliminary process evaluation of the program’s initial launch to inform and facilitate broadscale implementation. Methods:We used a longitudinal, holistic approach to redesign the UIWSOM FD program to provide evidence-informed and experiential learning for faculty. We performed a process evaluation of the initial iteration of the FD program using an inductive qualitative research approach. We applied principles of constructivist grounded theory to analyze faculty’s responses collected during semi-structured interviews.Results:Three themes emerged from our analysis: communication, advocacy, and reciprocal learning. We found that effective communication, advocacy for faculty success, and reciprocal value between faculty and program developers undergirded the core concept of authentic engagement. Faculty’s perceptions of the quality of engagement of those implementing the program overshadowed the quality of the logistics. Conclusions:Our pilot study identified authentic engagement as critical to faculty’s positive experience of this new FD initiative. Practical implications for other health professions schools with similar FD initiatives include consideration of the relational aspects. Future studies should expand the process evaluation to determine key factors driving perceived program success for other skill domains and amongst clinical faculty, and include a long-range outcome evaluation of the fully implemented program.
Delay Information in Virtual Queues: A Large-Scale Field Experiment on a Major Ride-Sharing Platform
Authors: Yu Qiuping , Zhang Yiming , Zhou Yong-Pin 
Published: June 2022

The growing adoption of virtual queues in the service and retail industries has been greatly accelerated in recent times. In collaboration with a major ride-sharing platform, we study how the wait time information (WTI), both its initial magnitude and its subsequent progress over time, impacts customers’ abandonment behavior in virtual queues. The study was conducted through a randomized field experiment that included 1,425,745 rides: one-third of the rides received a neutral WTI, one-third received an optimistic WTI shorter than the neutral WTI (hence less frequent updates), and one-third received a pessimistic WTI (hence more frequent updates). The underlying wait time did not vary across the three groups. We find that both the magnitude of the initial WTI and the update frequency of the WTI have a significant impact on customer abandonment. Specifically, when adjusting the initial WTI by one minute, it did not impact customer abandonment. This is because the magnitude effect of the initial WTI is cancelled out by the opposite update-frequency effect. However, when adjusting the WTI by more than one minute, the magnitude effect dominates: when comparing the pessimistic WTI of four minutes with the neutral initial WTI of two minutes, five minutes with three minutes, and eight minutes with five minutes, customers’ likelihood to abandon increases by 6.2%, 14.1%, and 19.6%, respectively. Similar but opposite effects are found when comparing the optimistic WTI with the neutral WTI. We discuss how firms can use our findings and insights to design and operate better virtual queues. This paper was accepted by Vishal Gaur, operations management.
Garum, Fonte de Proteína dos Romanos
Authors: Duprat Paulo Pires 
Published: June 2022

Neste artigo vamos apresentar os resultados preliminares da pesquisa de doutorado, cujo tema principal é o garum romano. A ideia é fazer uma abordagem sobre as últimas novidades acerca da trajetória histórica do garum no entorno do Mediterrâneo, com especial atenção para a Hispânia no período do Principado. Nosso objetivo é oferecer um estudo de cunho multidisciplinar capaz de dar nexo à imensa quantidade de dados gerados sobre o tema nas últimas décadas, buscando mudar a persistente noção de que o consumo de garum estaria reservado às elites, apresentando evidências literárias e arqueológicas que comprovam que o produto foi um fenômeno técnico e comercial multifacetado, uma fonte de proteína de baixo custo para o povo romano, empacotada e despachada a longa distância, sob o bojo de um processo histórico cujos desdobramentos ainda podem ser sentidos.
FOC winding defect detection based on improved texture features and
low-rank representation model
Authors: Chen Xiaole , Yang Ruifeng , Guo Chenxia , Zhang Qianchuang 
Published: June 2022

The
defect detection of
fiber-optic coils (FOCs) plays an important role in the quality
control of the FOC production. In order to overcome the problems of
poor performance and low reliability of existing methods, this paper
provides a solution for winding defect detection of FOCs based on
low-rank representation (LRR) technology. First, we design a feature
matrix, which represents the image. Then the LRR model is employed to
formulate the defect detection task as a problem of low rank and
sparse matrix decomposition. Meanwhile, Laplacian regularization is
introduced as a smoothness constraint to expand the distance between
defect regions and low-rank background. Experiments are performed on a
real dataset to verify the algorithm. The results show that the
proposed winding defect detection method of FOCs achieves the highest
detection accuracy and lowest false alarm rate compared to other
methods, verifying the effectiveness of the proposed method.
Multi-wavelength injection locked semiconductor comb laser
Authors: Chen Jia-Jian , Wei Wen-Qi , Qin Jia-Le , Yang Bo , Huang Jing-Zhi , Wang Zi-Hao , Wang Ting , Yu Chang-Yuan , Zhang Jian-Jun 
Published: June 2022

Quantum dot lasers on silicon have gained significant interest over the past decade due to their great potential as an on-chip silicon photonic light source. Here, we demonstrate multi-wavelength injection locking of InAs/GaAs quantum dot Fabry–Perot (FP) lasers both on GaAs and silicon substrates by optical self-injection via an external cavity. The number of locked laser modes can be adjusted from a single peak to multiple peaks by tuning wavelength dependent phase and mode spacing of back-injected light through a Lyot filter. The multi-wavelength injection locked laser modes exhibit average optical linewidth of

∼
20

kHz

, which are narrowed by approximately three orders of magnitude from their free-running condition. Furthermore, multi-wavelength self-injection locking via an external cavity exhibits flat-top optical spectral properties with approximately 30 stably locked channels under stable operation over time, where the frequency detuning is less than 700 MHz within 40 min. Particularly, FP lasers by direct epitaxial growth on silicon substrates are self-injection locked as a flat-top comb source with tunable free spectral range from approximately 25 to 700 GHz. The reported results emphasize the great potential of multi-wavelength injection locked lasers as tunable on-chip multi-wavelength light sources.
Acetylsalicylic acid use is associated with reduced risk of out-of-hospital cardiac arrest in the general population: Real-world data from a population-based study
Authors: Eroglu Talip E. , Blom Marieke T. , Souverein Patrick C. , Yasmina Alfi , de Boer Anthonius , Tan Hanno L. ,   for the ESCAPE-NET investigators
Published: June 2022

Aim
Activated blood platelet products facilitate myocardial intracellular Ca2+ overload, thereby provoking afterdepolarizations and increasing susceptibility of ischemic myocardium to ventricular fibrillation (VF). These effects are counteracted in vitro by acetylsalicylic acid (ASA), but no prior study investigated whether ASA is associated with decreased out-of-hospital cardiac arrest (OHCA) risk on a population level. Therefore, we studied whether ASA and other antiplatelet drugs (carbasalate calcium, clopidogrel) are associated with decreased risk of OHCA.

Methods
We conducted a population-based case-control study among individuals (772 OHCA-cases with documented VT/VF, 2444 non-OHCA-controls) who had used antiplatelet drugs in the year before index-date (OHCA-date), and studied the association between current antiplatelet drug use and OHCA-risk with multivariable logistic regression analysis.

Results
ASA use was associated with reduced OHCA-risk (adjusted odds ratio (ORadj) 0.6 [0.5–0.8]), and more so in women (ORadj 0.3 [0.2–0.6]) than in men (ORadj 0.7 [0.5–0.95], Pinteraction 0.021). Carbasalate calcium was associated with decreased OHCA-risk in women (ORadj 0.5 [0.3–0.9]), but not in men (ORadj 1.3 [0.96–1.7], Pinteraction 0.005). Clopidogrel was not associated with reduction in OHCA-risk. Risk reduction associated with ASA in patients with OHCA was similar in the presence of acute myocardial infarction (AMI) (ORadj 0.6 [0.4–0.9]) and in the absence of AMI (ORadj 0.7 [0.4–1.2]).

Conclusion
ASA use was associated with reduced OHCA-risk in both sexes, and more so in women, while carbasalate calcium only protected women. Clopidogrel was not associated with reduced OHCA-risk.
Methodological approaches for assessing certainty of the evidence in umbrella reviews: A scoping review
Authors: Sadoyu Saranrat , Tanni Kaniz Afroz , Punrum Nontaporn , Paengtrai Sobhon , Kategaew Warittakorn , Promchit Nattiwat , Lai Nai Ming , Thakkinstian Ammarin , Ngorsuraches Surachat , Bangpan Mukdarut , Veettil Sajesh , Chaiyakunapruk Nathorn 
Published: June 2022

Introduction
The number of umbrella reviews (URs) that compiled systematic reviews and meta-analysis (SR-MAs) has increased dramatically over recent years. No formal guidance for assessing the certainty of evidence in URs of meta-analyses exists nowadays. URs of non-interventional studies help establish evidence linking exposure to certain health outcomes in a population. This study aims to identify and describe the methodological approaches for assessing the certainty of the evidence in published URs of non-interventions.

Methods
We searched from 3 databases including PubMed, Embase, and The Cochrane Library from May 2010 to September 2021. We included URs that included SR-MAs of studies with non-interventions. Two independent reviewers screened and extracted data. We compared URs characteristics stratified by publication year, journal ranking, journal impact factor using Chi-square test.

Results
Ninety-nine URs have been included. Most were SR-MAs of observational studies evaluating association of non-modifiable risk factors with some outcomes. Only half (56.6%) of the included URs assessed the certainty of the evidence. The most frequently used criteria is credibility assessment (80.4%), followed by GRADE approach (14.3%). URs published in journals with higher journal impact factor assessed certainty of evidence than URs published in lower impact group (77.1 versus 37.2% respectively, p < 0.05). However, criteria for credibility assessment used in four of the seven URs that were published in top ranking journals were slightly varied.

Conclusions
Half of URs of MAs of non-interventional studies have assessed the certainty of the evidence, in which criteria for credibility assessment was the commonly used method. Guidance and standards are required to ensure the methodological rigor and consistency of certainty of evidence assessment for URs.
KONSEP MAHABBAH JALALUDDIN RUMI
Authors: Octafany Assya 
Published: June 2022

This article explores Rumi's mahabbah concept. Currently, in society, the concept of love is degrading in meaning, resulting in its constriction. This is because the concept of mahabbah, which we usually refer to as "love," is unfamiliar to the general population. In general, society equates love with liking the other sex. Spite of the fact , Rumi asserts that love is not confined to that. The notion of love will be addressed in this study via the lens of Jalaluddin Rumi, specifically the nature of love and its application in life. The findings of this study provide an outline of the type of love that people should possess: love powerful enough to cause someone to love their god.
Okul Yöneticisi Seçme Sürecini Deneyimleyen Yönetici Adaylarının Sözlü Sınav Yöntemine İlişkin Algıları
Authors: YOLCU Hüseyin , BAYRAM Arslan 
Published: June 2022

Bu çalışmanın amacı, okul yöneticisi seçme sürecini deneyimleyen yönetici adaylarının sözlü sınav yöntemine ilişkin algılarını ortaya koymaktadır. Araştırmada fenomenoloji deseni kullanılmıştır. Araştırmada maksimum çeşitlilik ve ölçüt örnekleme yöntemlerine uygun 10 kişilik bir çalışma grubu oluşturulmuştur. Araştırmanın verileri çalışma grubunda yer alan yönetici adaylarıyla yapılan yarı-yapılandırılmış görüşmelerin yanı sıra doküman toplama yöntemiyle elde edilmiştir. Araştırmada elde edilen nitel veriler içerik analizi kullanılarak çözümlenmiştir. Araştırmada elde edilen bulgular yönetici adaylarının sözlü sınavda başarılı olmaları, kişisel faktörlerden daha çok çevresel faktörlere bağlı olduğu yönündedir. Yönetici adayları, yönetici seçme sınavının yalnızca sözlü sınava dayalı olarak gerçekleştirilmesinin, kendileri üzerinde olumsuz psikolojik etkilere yol açtığını düşünmektedir. Çalışma grubundan elde edilen veriler sözlü sınavın yönetici yeterliklerini ölçmede son derece yetersiz kaldığını ortaya koymaktadır. Yönetici seçme sınavında sözlü sınava göre daha nesnel, geçerlik ve güvenirliği daha yüksek olan yazılı sınavlara başvurulmalıdır. Sözlü sınav, yazılı sınavların eksik bıraktığı yeterlik alanlarını ölçmede kullanılmalı ancak adayın yazılı sınavdaki başarı/başarısızlığının önüne geçmemelidir.
IMPLEMENTASI FILTER GRAY LEVEL CO-OCCURANCE MATRIKS TERHADAP SISTEM KLASIFIKASI KANKER PAYUDARA DENGAN METODE CONVOLUTIONAL NEURAL NETWORK
Authors: Rohman Muhammad Ariefur , Mudjirahardjo Panca , Muslim M. Aziz 
Published: June 2022

Kanker payudara merupakan salah satu penyakit dengan proyeksi kematian terbesar selama 10 tahun terakhir dengan indeks kematian mencapai rata-rata 5 juta per-tahun, dan diprediksi akan terus naik hingga 60% di seluruh dunia. Umumnya, banyak metode yang digunakan untuk mendeteksi penyakit ini, salah satunya dengan mengamati jaringan histopatology. Banyak dari para ilmuwan, yang menggunakan jaringan histopatology untuk menganalisa, mengamati dan membuat sistem klasifikasi kanker payudara dengan berbagai metode, seperti: convolutional neural network, deep learning, support vector machine. Penggunaan metode convolutional neural network terbukti paling unggul pada sistem klasifikasi kanker payudara, namun akurasi rata-rata yang dihasilkan relatif cukup rendah. Selain itu, penggunaan metode convolutional neural network, membutuhkan waktu komputasi yang relatif lama untuk mengklasifikasikan 7909 dataset ukuran 4 GB. Berdasarkan alasan tersebut, desain sebuah sistem klasifikasi dengan mengimplementasikan Gray Level Co-occurance Matrix pada saat prapengolahan data CNN di butuhkan. Hasil penelitian menunjukkan bahwa, penggunaan metode CNN menghasilkan waktu komputasi lebih lama, yaitu: 3300 detik dibandingkan dengan kombinasi metode GLCM Entropy dan CNN 2040 detik. Sedangkan rata-rata akurasi latih dan uji yang dihasilkan oleh metode kombinasi GLCM entropy dan CNN adalah 92,26% dan 94,16%, lebih unggul dibandingkan dengan metode CNN, yaitu: 88,41% untuk data latih, dan 87,68% untuk data uji.
DESIGN AND SIMULATION OF BUILDING BLOCKS OF A LOW-DROPOUT VOLTAGE REGULATOR
Authors: Wardhana Arief Wisnu , Nugraha Azis Wisnu Widhi , Atmojo Eko , Fadli Ari 
Published: June 2022

Low dropout regulators (LDOs) are a simple and inexpensive way to regulate an output voltage that is powered from a higher voltage input [1]. An LDO regulator is a DC linear voltage regulator that can regulate the magnitude of the output voltage even when the supply voltage is very close to the output voltage. In this research paper, various building blocks of a CMOS-based low-dropout voltage regulator were designed and simulated using Multisim LIVE, an online circuit simulator. All of the building blocks were then combined to form the device. Based on the results of the simulation, several spesifications of the LDO were determined. Those are the LDO’s dropout voltage, its quiescent current, its load regulation, and its line regulation. At the end of the design process, during testing it can be shown that this LDO resulted in a dropout voltage of magnitude 200 mV at 200 mA load current which is quite a low dropout voltage. The design has a quiescent current of magnitude 300 , a load regulation of magnitude , and a line regulation of magnitude .