bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional movement disorder is associated with abnormal interoceptive brain activity: a task-based functional MRI study
Authors: Spagnolo Primavera A. , Parker Jacob A. , Hallett Mark , Horovitz Silvina G. 
Published: February 2025

BackgroundAberrant interoceptive processing has been hypothesized to contribute to the pathophysiology of functional neurological disorder, although findings have been inconsistent. Here, we utilized functional magnetic resonance imaging (fMRI) to examine neural correlates of interoceptive attention – the conscious focus and awareness of bodily sensations – in functional movement disorder (FMD).MethodsWe used voxelwise analyses to compare blood oxygenation level-dependent responses between 13 adults with hyperkinetic FMD and 13 healthy controls (HCs) during a task requiring attention to different bodily sensations and to an exteroceptive stimulus. Additionally, we examined between-group differences in self-reported measures of interoception and evaluated their relationship with neural activity.ResultsInteroceptive conditions (heartbeat, stomach and ‘body’, indicating sensations from the body part or limb affected in FMD participants) activated a network involving the precuneus, the posterior cingulate cortex (PCC) and caudate nucleus (CN) bilaterally, and the right anterior insula (aINS) (p &lt;0.05, corrected). Group differences in brain activity were mainly driven by processing of disease-related interoceptive signals, which in the FMD group was associated with a broader neural activation than monitoring gastric interoception, while no group differences were detected during cardiac interoception. Differences based on interoceptive focus (body vs heartbeat and stomach) between FMD subjects and HCs were found in PCC, CN, angular gyrus, thalamus, and in the mid-insula (p &lt;0.05, corrected).ConclusionsThis is, to our knowledge, the first study showing that FMD is associated with abnormal interoceptive processing in regions involved in monitoring body state, attentional focus, and homeostatic inference.
Health risky behaviors among rural-to-urban migrant workers in China: prevalence, patterns, and association with distal and proximal factors
Authors: Wang Weikai , Wang Mengting , Pan Hong , Jian Wenqian , Chen Li , Zheng Yawen 
Published: February 2025

BackgroundHealth Risky Behaviors (HRBs) pose a significant public health challenge, particularly among migrant workers in China who face unfavorable living and working conditions. This study aimed to investigate the prevalence and characteristics of HRBs in rural-to-urban migrant workers, as well as explore factors associated with HRBs from both distal and proximal perspectives.MethodsA cross-sectional survey involving 2,065 rural-to-urban migrant workers was conducted. Participants completed a structured questionnaire assessing HRBs, distal factors (school dropout, peer victimization, physical neglect/abuse, emotional neglect/abuse) and proximal factors (work burnout, parent-child conflict, adulthood poverty, divorce intention, core self-evaluation). Logistic regression analysis was utilized to identify predictors of HRBs, leading to the development and validation of a prediction model (nomograms) for HRBs among migrant workers. The model's performance was assessed using metrics such as the area under the curve (AUC), calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA).ResultsSignificant predictors of HRBs included gender, school dropout, peer victimization, abuse/neglect experiences, work burnout, parent-child conflict, adulthood poverty, divorce intention, and core self-evaluation. The developed nomogram showed promising predictive accuracy with an AUC of 0.77 for the training set and 0.76 for the validation set. The calibration curve demonstrated good alignment with the diagonal, and the DCA illustrated the model's utility across different threshold ranges.ConclusionThis study highlighted a high prevalence of HRBs among migrant workers in China, and the predictive tool developed can be instrumental in informing targeted interventions and policies to address and manage HRBs effectively among this population.
Awareness of and the relationship between noise-induced hearing loss and the use of personal listening devices in Jazan region, Saudi Arabia
Authors: Mokhatrish Mohammad M. , Dighriri Ramzi M. , Otaif Abdulrahman A. , Otaif Abdulelah A. , Jahlan Riyadh A. , Daghreeri Abdulrahman A. , Hakami Hussam T. , Mobarki Ameer M. , Daghriri Bandar F. , Hakami Fawaz M. , Dighriri Osama M. 
Published: February 2025

ObjectivesNoise-induced hearing loss (NIHL) is a significant global health issue, exacerbated by the increasing use of personal listening devices (PLDs). This study aims to assess the awareness of NIHL and its association with PLD use among residents in the Jazan region of Saudi Arabia.Materials and methodsA descriptive, cross-sectional study was conducted among Saudi adults in Jazan. A structured questionnaire was used to gather data on demographics, health-related characteristics, PLD usage patterns, and awareness of NIHL.ResultsThe study included 428 participants, with 53.3% males and 45.6% aged 18–25. Most participants used PLDs frequently, with 43.0% listening for an hour or less daily. Awareness of NIHL was moderate, with 81.1% recognizing the harmful effects of loud noise on hearing. However, misconceptions about early signs and prevention of hearing loss (HL) were prevalent. The mean HL score was 8.9 (SD: 2.8) out of 20; which reflects low level of HL among the study participants. Males were 1.6 folds more likely to have higher level of HL compared to females (p = 0.015). Participants who prefer high volume level (above 70 dB) were more than 2-folds likely to have higher level of HL compared to others (p &lt; 0.01).ConclusionThe study highlights moderate level of awareness of NIHL and the risks of PLDs in Jazan region of Saudi Arabia. However, implementing preventive measures, especially among younger demographics, remains a challenge. The findings suggest the need for targeted public health interventions and technology to strengthen hearing conservation strategies.
Evaluation of estrogenic and anti-estrogenic activity of endocrine disruptors using breast cancer spheroids: a comparative study of T47D and MCF7 cell lines in 2D and 3D models
Authors: Barbaro Katia , Innocenzi Elisa , Monteleone Valentina , Marcoccia Daniele , Altigeri Annalisa , Zepparoni Alessia , Caciolo Daniela , Alimonti Cristian , Mollari Marta , Ghisellini Paola , Rando Cristina , Eggenhöffner Roberto , Scicluna Maria Teresa 
Published: February 2025

IntroductionThe estrogenic and anti-estrogenic effects of endocrine disruptors were examined in vitro using two-dimensional 2D and three-dimensional 3D estrogen receptor-positive T47D and MCF7 human breast cancer cells.MethodsThe in vitro model system was used to test the plasticizer Bisphenol A (BPA), a known endocrine disruptor (EDs) with estrogen-like action, aga inst 17β-Estradiol (E2), the endogenous nuclear estrogen receptor (nERs) ligand, and the anti-estrogenic drug Fulvestrant (FUL). Spheroid formation and gene expression of estrogen-regulated markers (pS2 and TGFβ3) both in 2D and 3D cultures were used to establish the dose-dependent cellular effects of these substances, evaluated cell viability either by separately treating with the individual substances or in co-treatment.ResultsBPA exhibited a dose-dependent estrogenic activity in both 2D and 3D cultures, significantly influencing cell proliferation and gene expression of estrogen-regulated markers (pS2 and TGFβ3). In contrast, FUL displayed anti-estrogenic properties, effectively inhibiting the proliferative effects of E2, thereby highlighting the complex interactions between these compounds and the nERs pathways in human breast cancer cells.DiscussionOur findings indicate that E2 and BPA significantly increase pS2 expression while decreasing TGFβ3, and that FUL co-treatment reverses these effects. Therefore, the in vitro model system could serve to observe the cell-mediated effects caused by the interaction of EDs with nERs. Through the use of these in vitro model systems - 2D and especially 3D, the latter of which allow better emulation of complex physiological and pathological processes occurring in vivo, the effects caused by EDs on nERs pathways can be detected and studied under various conditions. This approach performs as a preliminary screening tool to identify estrogenic substances, offering the potential to reduce reliance on in vivo experiments and contributing to improved environmental and health risk assessments.
Characterization of Monotone Sequences of Positive Numbers Prescribed by Means
Authors: Tóth János T. , Filip Ferdinánd , Svitek Szilárd , Václavíková Zuzana 
Published: February 2025

The aim of this article is to investigate the relations between the exponent of the convergence of sequences and other characteristics defined for monotone sequences of positive numbers. Another main goal is to characterize such monotone sequences (an) of positive numbers that, for each n≥2, satisfy the equality an=K(an−1,an+1), where the function K:R+×R+→R+ is the mean, i.e., each value of K(x,y) lies between min{x,y} and max{x,y}. Well-known examples of such sequences are, for example, arithmetic (geometric) progression, because starting from the second term, each of its terms is equal to the arithmetic (geometric) mean of its neighboring terms. Furthermore, this accomplishment generalized and extended previous results, where the properties of the logarithmic sequence (an) are referred to, i.e., in such a sequence that every n≥2 satisfies an=L(an−1,an+1), where L(x,y) is the logarithmic mean of positive numbers x,y defined as follows: L(x,y):=y−xlny−lnxifx≠y,xifx=y.
Моделирование растворимости гесафторацетилацетоната палладия в диоксиде углерода
Authors: Костенко М.О. , Восков А.Л. , Зуев Я.И. , Курыкин М.А. , Паренаго О.О. 
Published: February 2025

Рассмотрены два варианта моделирования растворимости гексафторацетилацетоната палладия в диоксиде углерода (в суб- и сверхкритических условиях) на основе ранее полученных экспериментальных данных. В рамках первого варианта использовали уравнение состояния Пенга—Робинсона, в качестве альтернативного — уравнение Крастила. Были найдены оптимальные параметры модельных уравнений. Оба варианта моделирования позволили с удовлетворительной точностью описать изотермы растворимости в диапазоне температур 313—353 K и мольных долей комплекса до 0,8 %. Стандартные отклонения при этом составляли 2,6 г/л и 2,0 г/л для уравнений Пенга—Робинсона и Крастила соответственно.
The paper considers two approaches for modeling the solubility of palladium hexafluoroacetylacetonate in carbon dioxide under sub- and supercritical conditions based on previously collected experimental data. The first approach uses the Peng—Robinson equation of state, while the second uses the Chrastil equation as an alternative. During the study, optimal parameters for the model equations were determined. Both modeling approaches allowed for a satisfactory approximation of the solubility isotherms within the temperature range of 313—353 K and a molar fraction of the complex of up to 0.8%. Standard deviations for the Peng—Robinson and Chrastil models were 2.6 and 2.0 g/l, respectively.
A Atuação do Terapeuta Ocupacional na Hemofilia: Relato de Caso
Authors: Pereira Elisa 
Published: February 2025

Introdução: A hemofilia é um distúrbio hereditário grave de coagulação sanguínea que pode provocar deformidades e incapacidades permanentes ou transitórias, comprometendo o desempenho ocupacional em algumas áreas de desempenho do paciente acometido. Procedimento metodológico: este é um relato de caso que visa apresentar a atuação do Terapeuta Ocupacional junto a um lactente com hemofilia A grave durante o período de hospitalização no Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti – Hemorio. Discussão: a importância da Terapia Ocupacional no trabalho da equipe multidisciplinar humanizada, sendo essencial para a organização das funções físicas e mentais do paciente, através de práticas profissionais em conjunto. Conclusão: ressalta-se a necessidade da atuação terapêutica ocupacional nos casos de hemofilia desde a profilaxia a reabilitação. O profissional Terapeuta Ocupacional fazendo uso dos seus conhecimentos técnicos, avaliando e definindo o programa de tratamento, observando a relação entre a pessoa, seu envolvimento em ocupações importantes e o contexto/ambiente nos quais está inserida.
Vertical and Temporal H3
+ Structure at the Auroral Footprint of Io
Authors: Mura A. , Moirano A. , Hue V. , Castagnoli C. , Migliorini A. , Altieri F. , Adriani A. , Cicchetti A. , Plainaki C. , Piccioni G. , Noschese R. , Sindoni G. , Sordini R. 
Published: February 2025

Abstract
We report the first observation of the vertical and temporal structure of the H3
+ emission at the auroral footprint of Io, as observed by Juno/JIRAM. The brightness vertical profile shows a maximum at 600 km above 1 bar, with no apparent difference between the main Alfvén wing (MAW) spot emission and the tail of the footprint. This observation better aligns with a broadband energy distribution of the precipitating electrons, instead of a monoenergetic one. The temporal profile of H3
+ column density has been observed after the passage of the MAW and shows a hyperbolic decrease. A model of H3
+ decay is proposed, which takes into account the second-order kinetics of dissociative recombination of H3
+ ions with electrons. The model is found to be in very good agreement with Juno observations. The conversion factor from radiance to column density has been derived, as well as the half-life for H3
+, which is not constant but inversely proportional to the H3
+ column density. This explains the wide range of H3
+ lifetimes proposed before.
DiSSCo RI: the Cost Book for DiSSCo
Authors: Landel Salomé , Guiraud Michel , Casino Ana , Worley Katharine 
Published: February 2025

The European Research Infrastructure DiSSCo (Distributed System of Scientific Collections) aims to digitally unify all European natural science assets, to ensure that collection data are easily findable, accessible, interoperable and reusable (FAIR). 170 institutions across more than 23 countries are involved in this ambitious objective of transforming a fragmented landscape of collections into an integrated knowledge base, enabling researchers to use and interconnect different collections.
Research Infrastructure (hereinafter referred as to RI) cost calculation can be multifaceted and complex. DiSSCo is both a central team and a coordinated network responsible for supplying the infrastructure’s services. The RI linked costs are spread all over Europe and connect thousands of people. As the extended DiSSCo perimeter encompasses a wide range of services - from physical access, to digitisation on demand and consulting services - distributed amongst a great number of partners, cost information is spread across centralised and decentralised areas.
The following article outlines the first “centralised” cost calculation exercise for DiSSCo and concludes that the DiSSCo Central Hub office would need a minimum annual budget of 1.4 million euros to be operational. This would not change between the construction and the operation phases. Furthermore, the DiSSCo Central Hub IT team would need a budget of 2.2 million euros to finalise all IT systems under the construction phase (if the construction phase lasts two years, it would cost around 1.1 million euros per year) in order to develop the digital services that will facilitate access to NSC data. The annual cost to operate these services would be around 1.2 million euros per year. This budget will evolve according to funding opportunities, the enlargement of the membership and the implementation of a business model open to new sources of income. As is often the case, research infrastructures grow over time and the more DiSSCo becomes known and recognised, the more it will attract users and the more its budget will increase.
In order to calculate the RI linked costs, which are spread all over Europe, we developed a cost calculation methodology that has been distributed amongst all the 170 DiSSCo partner institutions. Twenty-seven institutions responded to the exercise. This allows for a first shared understanding on how to calculate DiSSCo related costs. It also provides the first figures on a cost-per-hour or a cost-per-service basis and it opens the door for the pricing of DiSSCo services. Finally, such a methodology also aims at guaranteeing a fair service pricing, based on the same principles and variables.
Autour du Mare nostrum : entre connectivité et exclusion
Authors: Lévêque Laure 
Published: February 2025

Loin de l’objectivation que devrait leur valoir d’appartenir à une typologie géographique, mers et océans charrient une imagerie à la fois liquide et profondément sédimentée qui leur donne leur coloration identitaire. À cet égard, celle de la Méditerranée tient à une formule : mare nostrum. Mais ce au prix d’une lecture pour le moins partiale, qui occulte les conditions d’énonciation de la devise et ce qu’elle doit à l’affirmation de l’hégémonie de Romains qui n’entendent pas par là ouvrir l’espace méditerranéen au partage mais faire valoir leurs droits à y évoluer en maîtres. Mise en avant, l’étymologie concordataire a servi à masquer bien des impostures ou, à tout le moins des distorsions, sous couvert de fraternité, alors même que la volonté de puissance n’a jamais baissé pavillon. À l’heure où, nonobstant les projets d’Union pour la Méditerranée, les tensions se ravivent dans le bassin méditerranéen, la riche littérature qu’il suscite assume une fonction démystifiante de la plus haute importance, qui dépouille ce que le mythe du mare nostrum a de fallacieux pour en appeler à donner enfin son plein contenu d’humanité à un mare nostrum si continûment confisqué.
La Méditerranée dans Corinne ou l’Italie de Mme de Staël : un espace littéraire de connectivité soi / autre / autres
Authors: Leopizzi Marcella 
Published: February 2025

Cette étude analyse les renvois à la mer et tout particulièrement à la Méditerranée contenus dans Corinne ou l’Italie (1807) de Louise Germaine Necker (devenue Madame de Staël-Holstein), afin d’examiner les divers “rôles” que ce bassin joue, voire les sémantisations de cette image. Cet essai met en évidence que, toile de fond du voyage de Corinne et d’Oswald, la Méditerranée assume la fonction de décor du paysage et de voix de la nature et que sa présence est saisissable non seulement par la vue mais aussi par l’écoute et par l’odorat ; en outre, dangereuse et périlleuse, elle constitue aussi un espace où prêter assistance ; et, qui plus est, elle apparaît tel un moteur-créateur de rêveries et de réflexions ainsi que comme le domaine personnel des souvenirs. Par ce travail, l’auteure vise à démontrer que, dans cet ouvrage, la Méditerranée subsume la connexion moi/autre et moi/moi-profond et enclenche l’image de la liaison soi/autre/autres qui évoque une vision unificatrice de la diversité. Loin d’être le centre exclusif des modèles civilisationnels, la Méditerranée dialogue avec une nouvelle géographie culturelle européenne.
Mémoire des catastrophes et sensibilisation aux risques : le « hub mémoriel inondations » (projet CART.OCC)
Authors: Meschinet de Richemond Nancy 
Published: February 2025

La gestion des risques naturels intègre aujourd’hui leur dimension géohistorique, à travers la mémoire des évènements passés qui peut être mobilisée comme outils de transmission d’informations et de sensibilisation aux risques. Dans le cadre d’une acception de plus en plus large de « l’environnement », cette mémoire des catastrophes naturelles peut également être intégrée en tant que patrimoine culturel participant d’une identité locale. Au sein du projet CART.OCC de l’université Paul Valéry, qui vise à valoriser le patrimoine culturel d’Occitanie-Est au moyen de la web-cartographie enrichie, le projet de « hub mémoriel inondations » est en cours de développement avec l’ambition de contribuer à la sensibilisation au risque d’inondations catastrophiques méditerranéennes. La présentation de cette étude de cas permettra de montrer combien la mémoire des inondations ne doit plus être abordée comme un objet statique mais comme un objet complexe et dynamique, dont l’ancrage territorial est en construction permanente et articule différentes échelles spatio-temporelles.
The ‘Bounce Back’ rehabilitation programme for stroke survivors in South Africa – a case report
Authors: Sujee Laeeqa , Hildebrandt Sacha , Harrison Amy , Matjekane Christa , Mmoledi Thabiso , Pilusa Sonti , Sekome Kganetso , Ajidahun Adedayo T. 
Published: February 2025

Introduction: Stroke is one of the global leading causes of disability, with a higher prevalence at a younger age in sub-Saharan Africa. Returning to functional status is a primary goal of rehabilitation for stroke survivors. However, the cost of intensive rehabilitation is often a barrier for the under-resourced in South Africa.Patient presentation: This article describes the individualised ‘return-to-function’ approach to rehabilitation and its outcomes for five stroke survivors delivered through a non-profit public–private partnership in a low-income community in South Africa.Management and outcome: A retrospective case series of stroke survivors who participated in the Bounce Back Journey (BBJ) programme between 2019 and 2021 was conducted. The beneficiaries’ ages ranged from 21 to 55 years; two were females and three were males. The goals and outcomes of five stroke survivors with impairments, functional limitations and participation restrictions admitted into the BBJ programme were evaluated through standardised outcome measures. All the beneficiaries required financial support and extensive rehabilitation to return to a functional life. All showed improved outcomes in functional independence and health-related quality of life at discharge. Depressive symptoms clinically deteriorated in one patient. At discharge, all participants faced challenges finding opportunities to return to work.Conclusion: The case series demonstrates how an alternative community-based rehabilitation programme has the potential to improve functionality, health-related quality of life and mental health.Contribution: A low-cost, community-based, intensive rehabilitation programme can improve functionality, but return to work and community re-integration opportunities remain limited.
Infraorbital Dirofilariasis: Conundrum Solved by High-resolution Ultrasound
Authors: Thakker Vishal , Sadhu Sanjay , Khan Sadaf , Arora Manali , Saxena Deepali , Azad Rajiv Kumar 
Published: February 2025

Abstract
Human dirofilariasis by nematode worm Dirofilaria
repens is an uncommon zoonotic infection presenting most commonly as subcutaneous nodules after mosquito bites. Although the subcutaneous nodules can occur anywhere in the body, orbital and periorbital locations are most commonly involved. Imaging makes the cornerstone of diagnosis in cases with strong clinical suspicion since the nodular subcutaneous swelling has many clinical differentials. We present a case of an 11-year-old boy with infraorbital swelling, which was diagnosed to be dirofilariasis on imaging and postoperative histopathology.