bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDEKATAN PDCA (PLAN, DO, CHECK, ACTION) DALAM UPAYA MERINGANKAN DAMPAK EKONOMI AKIBAT PANDEMI COVID-19 DI CITAYAM
Authors: Nain Zulkar , Imam Saeful , MA Muryeti , Ningtyas Rina , Purnamasari Novi , Silvia Deli 
Published: March 2022

The COVID-19 pandemic has disrupted the community's economy, especially in the Depok Citayam area. This community service activity aims to help maintain food security for small and medium-sized communities who are experiencing economic impacts due to the COVID-19 outbreak in the Citayam Depok area as well as a medium for promoting the TICK study program and applying scientific fields in the implementation of community service. The PDCA approach was carried out with field surveys, in-depth interviews, and brainstorming as the basis for careful planning; manufacture of rice packaging and goody bags designed and made independently, checking with Pareto diagrams and distributing basic necessities in collaboration with DKM (Al Iklhlas Puri Bojong Lestari 2 Pabuaran Bojong Gede). This service activity has succeeded in providing 100 food packages and given to residents who need it most based on the data obtained.
Keywords: COVID-19, PDCA, Rice packaging and goody bags, Pareto diagram, Food security

Pandemik COVID-19 telah mengganggu ekonomi masyarakat khususnya di wilayah Depok Citayam. Kegiatan pengabdian masyarakat ini bertujuan untuk membantu menjaga ketahanan pangan masyarakat kecil menengah kebawah yang mengalami dampak ekonomi akibat wabah COVID-19 di daerah Citayam Depok serta sebagai media promosi program studi TICK dan penerapan bidang keilmuan dalam pelaksanaan pengabdian kepada masyarakat. Pendekatan PDCA dilakukan dengan survey lapangan, wawancara (in-depth interview) dan brainstorming sebagai dasar perencanaan yang matang; pembuatan kemasan beras dan goody bag yang dirancang dan dibuat secara mandiri, pengecekan dengan diagram Pareto dan penyaluran sembako kebutuhan pokok dengan bekerja sama dengan DKM (Al Iklhlas Puri Bojong Lestari 2 Pabuaran Bojong Gede). Kegiatan pengabdian ini telah berhasil memberikan 100 paket sembako dan diberikan ke warga yang paling membutuhkan berdasarkan data yang diperoleh.
Kata Kunci: COVID-19, PDCA, kemasan beras dan goody bag, diagram pareto, ketahanan pangan
PELATIHAN PEMASARAN HASIL BUDIDAYA CACING SUTRA PADA KOMUNITAS PETERNAK IKAN HIAS TAPOS DEPOK
Authors: Ekowati Lia 
Published: March 2022

Abstract
The ability to market business results is one of the factors that affect the success and achievement of the mission of an entity's vision of activities. The cultivation of silk worms developed by ornamental fish farmers Tapok Depok becomes a commodity that can increase income to deal with the impact of the covid19 pandemic. In 2021, the D4 Financial Accounting Study Program of the Department of Accounting of The State Polytechnic of Jakarta organized devotional activities with the aim of improving the year and ability regarding the marketing strategy of silkworm cultivation. The methods applied in this community service through training and mentoring of marketing activities of silkworm cultivation. Considering the fundamental efforts in helping the marketing of silkworm cultivation products, donated equipment used in the breeding of silk worms and a set of medicines as well as health advocates. One of the results of this training is in the form of a Manual for Marketing Silk Worm Cultivation Products Online. This book provides an explanation of the stages that silkworm breeders can take to market the results online. The ability to market and select marketing strategies are the main keys in the business in today's pandemic. And the use of technology and social media proved to be very positive in increasing income.
Keywords: marketing, silk worms, online media.

Abstrak
Kemampuan dalam memasarkan hasil usaha merupakan salah satu faktor yang mempengaruhi keberhasilan dan tercapainya misi visi kegiatan suatu entitas. Hasil budidaya cacing sutra yang dikembangkan oleh para peternak ikan hias Tapok Depok menjadi komoditas yang dapat meningkatkan penghasilan guna menghadapi dampak pandemi covid19. Pada tahun 2021 Program Studi D4 Akuntansi Keuangan Jurusan Akuntansi Politeknik Negeri Jakarta menyelenggarakan kegiatan pengabdian dengan tujuan meningkatkan pengetahun dan kemampuan mengenai strategi pemasaran budidaya cacing sutra. Metode yang diterapkan dalam pengabdian masyarakat ini melalui pelatihan dan pendampingan kegiatan pemasaran hasil budidaya cacing sutra. Mempertimbangkan upaya mendasar dalam membantu pemasaran hasil budidaya cacing sutra maka disumbangkan peralatan yang digunakan dalam pembiakan cacing sutra dan seperangkat obat-obatan serta pendukung Kesehatan. Salah satu hasil dari pelatihan ini berupa Buku Pedoman Pemasaran Hasil Budidaya Cacing Sutra Secara Online. Buku ini memberikan penjelasan mengenai tahapan yang dapat dilakukan oleh peternak cacing sutra untuk memasarkan hasilnya secara online. Kemampuan memasarkan dan pemilihan strategi pemasaran menjadi kunci utama dalam usaha di masa pandemic sekarang ini. Dan pemanfaatan teknologi serta media sosial terbukti sangat berdampak positif dalam meningkatkan penghasilan.
Kata kunci: pemasaran, cacing sutra, media online.
PENGARUH KOMUNIKASI TERHADAP EFEKTIVITAS KERJA PEGAWAI PADA BIRO PERLENGKAPAN DAN ENGELOLAAN ASET PROVINSI SUMATERA UTARA
Authors: Hanum Azizah 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh komunikasi terhadap efektivitas kerja pegawai Badan Koordinasi Penyuluhan Pertanian, Perikanan dan Kehutanan Sumatera Utara dan untuk mengetahui apa saja faktor yang mempengaruhi efektivitas kerja pegawai Badan Koordinasi Penyuluhan, Perikanan dan Kehutanan Sumatera Utara. Adapun teknik pengumpulan data yang dilakukan adalah mengolah data yang didapatkan dari hasil angket dan kemudian hasil penelitian ini akan diolah sedemikian rupa menggunakan analisis korelasi product moment. Kemudian dilakukan pengujian terhadap setiap variabel dengan membandingkan nilai t hitung dengan nilai t table sesuai dengan tingkat signifikansi yang digunakan.
Berdasarkan hasil perhitungan dengan menggunakan rumus korelasi produk momen, diperoleh korelasi sebesar 0,758, sedangkan nilai korelasi dalam tabel adalah 0,374. Dengan demikian hipotesis yang dirumuskan dalam penelitian ini dapat diterima kebenarannya, sebab 0,758 > 0,374. Berarti dalam penelitian ini ditemukan bahwa komunikasi berpegaruh terhadap efektivitas kerja pegawai pada Badan Koordinasi Penyuluhan Pertanian, Perikanan dan Kehutanan Sumatera Utara. Dan dari hasil pengujian dengan menggunakan uji t, diperoleh nilai t (hitung) adalah 5,928. Sedangkan nilai t (tabel) adalah 2,056 (taraf signifikan 0,05 dan dk = n-2, 28-2 = 26 yaitu t (tabel) = 0,05, (28) = 2,056. Jadi nilai t (hitung) lebih besar daripada t (tabel) atau 5,928 > 2,056. Dengan demikian hipotesis yang dirumuskan dapat diterima kebenarannya, yakni adanya pengaruh yang bermakna antara komunikasi dengan efektivitas kerja pegawai
DAMPAK REPUTASI UNDERWRITER TERHADAP UNERPRICING PADA PERUSAHAAN YANG MELAKUKAN INITIAL PUBLIC OFFERING
Authors: Batubara Enika Diana 
Published: March 2022

Dalam proses go public sebelum di perdagangkan di pasar sekunder, saham terlebih dahulu di jual ke pasar primer atau yang sering disebut sebagai pasar perdana. Penawaran saham secara perdana ke publik melalui pasar perdana ini dikenal dengan istilah initial public offering. Penawaran umum saham perdana merupakan kegiatan penawaran efek yang pertama kali dilakukan oleh perusahaan (emiten) dalam rangka menjual sahamnya kepada masyarakat di pasar modal. Harga saham perdana ditentukan berdasarkan kesepakatan antara perusahaan (emiten) dengan Underwriter (penjamin emisi), sedangkan harga di pasar sekunder ditentukan oleh mekanisme pasar (permintaan dan penawaran). Jika penentuan harga pada saat initial public offering lebih rendah dibandingkan dengan harga yang terjadi di pasar sekunder di hari pertama maka akan terjadi Underpricing. Di dalam kegiatan penawaran umum perdana terdapat suatu fenomena menarik yang disebut dengan Underpricing. Fenomena Underpricing merupakan gejala-gejala umum yang terjadi pada saat perusahaan melakukan penawaran umum saham perdana di pasar modal, dimana harga saham yang ditawarkan pada pasar perdana lebih rendah dibandingkan dengan harga saham setelah diperdagangkan di pasar sekunder. Namun faktor-faktor yang menyebabkan Underpricing ini berbeda-beda di setiap pasar modal.
A Fluorogenic Far Red-Emitting Molecular Viscometer for Ascertaining Lysosomal Stress in Live Cells and Caenorhabditis elegans
Authors: Silswal Akshay , Kanojiya Ashutosh , Koner Apurba Lal 
Published: March 2022

The cellular physiochemical properties such as polarity, viscosity, and pH play a critical role in cellular homeostasis. The dynamic change of lysosomal viscosity in live cells associated with different environmental stress remains enigmatic and needs to be explored. We have developed a new class of Julolidine-based molecular viscometers with an extended π-conjugation to probe the lysosomal viscosity in live cells. High biocompatibility, pH tolerance, and the fluorogenic response with far red-emission (&gt;600 nm) properties make these molecular viscometers suitable for live-cell fluorescence imaging in Caenorhabditis elegans. Among these probes, JIND-Mor is specifically designed to target lysosomes via simple modification. The real-time monitoring of lysosomal viscosity change under cellular stress was achieved. We believe that such a class of molecule viscometers has the potential to monitor lysosomal health in pathogenic conditions.
Predominant Bacterial and Viral Otopathogens Identified Within the Respiratory Tract and Middle Ear of Urban Australian Children Experiencing Otitis Media Are Diversely Distributed
Authors: Ngo Chinh C. , Massa Helen M. , McMonagle Brent A. , Perry Christopher F. , Nissen Michael D. , Sloots Theo P. , Thornton Ruth B. , Cripps Allan W. 
Published: March 2022

BackgroundOtitis media (OM) is one of the most common infections in young children, arising from bacterial and/or viral infection of the middle ear. Globally, Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) are the predominant bacterial otopathogens. Importantly, common upper respiratory viruses are increasingly recognized contributors to the polymicrobial pathogenesis of OM. This study aimed to identify predominant bacteria and viruses in the nasopharynx, adenoids and middle ears of peri-urban/urban South-East Queensland Australian children, with and without clinical history of chronic otitis media with effusion (COME) and/or recurrent acute otitis media (RAOM).MethodsSixty children, 43 diagnosed with OM and 17 controls with no clinical history of OM from peri-urban/urban South-East Queensland community were recruited to the study. Respiratory tract bacterial and viral presence were examined within nasopharyngeal swabs (NPS), middle ear effusions (MEE) and adenoids, using real-time polymerase chain reaction (RT-PCR) and bacterial culture.ResultsAt least one otopathogen present was observed in all adenoid samples, 86.1% and 82.4% of NPS for children with and without OM, respectively, and 47.1% of the MEE from the children with OM. NTHi was the most commonly detected bacteria in both the OM and control cohorts within the adenoids (90.0% vs 93.8%), nasopharynx (67.4% vs 58.8%) respectively, and in the MEE (OM cohort 25.9%). Viruses were detected in all adenoid samples, 67.4% vs 47.1% of the NPS from the OM and control cohorts, respectively, and 37% of the MEE. Rhinovirus was the predominant virus identified in the adenoids (85.0% vs 68.8%) and nasopharynx (37.2% vs 41.2%) from the OM and control cohorts, respectively, and the MEE (19.8%).ConclusionsNTHi and rhinovirus are predominant otopathogens within the upper respiratory tract of children with and without OM from peri-urban and urban South-East Queensland, Australia. The presence of bacterial otopathogens within the middle ear is more predictive of concurrent URT infection than was observed for viruses, and the high otopathogen carriage within adenoid tissues confirms the complex polymicrobial environment in children, regardless of OM history.
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder
Authors: Laghi Valerio , Rezelj Veronica , Boucontet Laurent , Frétaud Maxence , Da Costa Bruno , Boudinot Pierre , Salinas Irene , Lutfalla Georges , Vignuzzi Marco , Levraud Jean-Pierre 
Published: March 2022

Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other therapeutic or prophylactic interventions. We explored the small, cheap, and transparent zebrafish larva as a potential host for SARS-CoV-2. Bath exposure, as well as microinjection in the coelom, pericardium, brain ventricle, or bloodstream, resulted in a rapid decrease of SARS-CoV-2 RNA in wild-type larvae. However, when the virus was inoculated in the swim bladder, viral RNA stabilized after 24 h. By immunohistochemistry, epithelial cells containing SARS-CoV-2 nucleoprotein were observed in the swim bladder wall. Our data suggest an abortive infection of the swim bladder. In some animals, several variants of concern were also tested with no evidence of increased infectivity in our model. Low infectivity of SARS-CoV-2 in zebrafish larvae was not due to the host type I interferon response, as comparable viral loads were detected in type I interferon-deficient animals. A mosaic overexpression of human ACE2 was not sufficient to increase SARS-CoV-2 infectivity in zebrafish embryos or in fish cells in vitro. In conclusion, wild-type zebrafish larvae appear mostly non-permissive to SARS-CoV-2, except in the swim bladder, an aerial organ sharing similarities with the mammalian lung.
RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study
Authors: Varkoly Kyle , Tan Shaoyuan , Beladi Roxana , Fonseca David , Zanetti Isabela Rivabem , Kraberger Simona , Shah Chintan , Yaron Jordan R. , Zhang Liqiang , Juby Michael , Fath Ayman , Ambadapadi Sriram , House Melanie , Maranian Paul , Pepine Carl J. , Varsani Arvind , Moreb Jan , Schultz-Cherry Stacey , Lucas Alexandra R. 
Published: March 2022

BackgroundViral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.ObjectiveAn unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function.MethodsHigh-throughput sequencing of RNA isolated from blood samples was analyzed following chemotherapy for hematological malignancies (N = 28) and compared with left ventricular ejection fraction (LVEF).ResultsOn initial rigorous analysis, low levels of influenza orthomyxovirus and avian paramyxovirus sequences were detectable, but without significant correlation to LVEF (r = 0.208). A secondary broad data mining analysis for virus sequences, without filtering human sequences, detected significant correlations for paramyxovirus with LVEF after chemotherapy (r = 0.592, P &lt; 0.0096). Correlations were similar for LVEF pre- and post- chemotherapy for orthomyxovirus (R = 0.483, P &lt; 0.0421). Retrovirus detection also correlated with LVEF post (r = 0.453, p &lt; 0.0591), but not pre-chemotherapy, but is suspect due to potential host contamination. Detectable phage and anellovirus had no correlation. Combined sequence reads (all viruses) demonstrated significant correlation (r = 0.621, P &lt; 0.0078). Reduced LVEF was not associated with chemotherapy (P = NS).ConclusionsThis is the first report of RNA virus screening in circulating blood and association with changes in cardiac function among patients post chemotherapy, using unbiased, blinded, high-throughput sequencing. Influenza orthomyxovirus, avian paramyxovirus and retrovirus sequences were detectable in patients with reduced LVEF. Further analysis for RNA virus infections in patients with cardiomyopathy after chemotherapy is warranted.
The Relationship Between Atrial Cardiopathy Biomarkers and Prognosis of Patients With Embolic Stroke of Undetermined Source
Authors: Ning Yuye , Wei Meng , Song Wenfeng , Luo Guogang 
Published: March 2022

ObjectiveTo compare the proportion of atrial cardiopathy in patients with embolic stroke of undetermined source (ESUS) and other non-cardiac strokes, and to evaluate the prognostic value of atrial cardiopathy biomarkers in patients with ESUS.MethodsThis retrospective study enrolled patients with ischemic stroke from January 2018 to April 2020 in a single stroke center, and compared the proportion of atrial cardiopathy in (1) ESUS group, (2) large artery atherosclerosis (LAA) group, and (3) small-vessel occlusion (SVO) group. Then, it compared the baseline characteristics between ESUS patients with atrial cardiopathy and cardioembolism (CE) group. In addition, the relationship was compared between the biomarkers of atrial cardiopathy and prognosis in patients with ESUS.ResultsIn total, 316 patients with ischemic stroke were included that included 105 (33.23%) ESUS, 84 (26.58%) LAA, 73 (23.10%) SVO, and 54 (17.09%) CE. Among these patients, patients with ESUS were younger, and had lower triglyceride, lower low-density lipoprotein than non-ESUS group. The proportion of atrial cardiopathy in ESUS group was higher than LAA group or SVO group (42.86 vs. 17.86 vs. 8.22%, p &lt; 0.001). Compared with non-atrial cardiopathy group, patients with atrial cardiopathy were older, had lower EF value, larger left ventricular diameter, and longer PR interval. Among 105 patients with ESUS, 11 (10.78%) cases died, 32 (31.37%) cases had poor functional outcome (mRS &gt;2). In the multivariable model, the risk factor associated with the death risk of patients with ESUS was N-terminal pro-B-type natriuretic peptide (NT-proBNP) &gt;250 pg/ml [p = 0.025, hazard ratio (HR) = 4.626, 95% CI: 1.212–17.652] after a 1-year follow-up.ConclusionsAtrial cardiopathy is more common in patients with ESUS, and the characteristics of ESUS patients with atrial cardiopathy are similar to those in patients with CE. NT-proBNP &gt;250 pg/ml is related to the risk of death in patients with ESUS.
Time Constraints of Late Cenozoic Tectonic Deformation of the Atushi Anticline, Southwestern Tian Shan: Evidence From Cosmogenic Nuclide Burial Age
Authors: Chen Qingyu , Fu Bihong , Shi Pilong , Kong Ping 
Published: March 2022

With the latest uplift episode of Tian Shan occurring since early Miocene, a series of thrust–fold belts were formed in front of Tian Shan. The Kashi foreland thrust–fold belt (KFTB) provided a unique case to understand the ongoing intracontinental deformation within the Pamir–Tian Shan convergence zone (PTCZ). Previous cosmogenic nuclide chronological studies on growth folds suggested that the young thrust–fold belt in front of Pamir formed during 6–1.07 Ma. However, the age constraints of late Cenozoic deformation in front of southwestern Tian Shan are still debated. In this study, we attempt to constrain the initial deformation time of the NEE-striking Atushi anticline (ATA) in the KFTB through the cosmogenic nuclide burial dating data of growth strata near the boundary between Pliocene–Pleistocene Atushi Formation and Xiyu Formation (Xiyu Conglomerate), which are exposed in the southern limb of ATA. Moreover, detailed geological interpretations of multiple remote sensing images and field investigations are also carried out to document the late Cenozoic structural deformation and geomorphologic features of ATA. The 26Al/10Be burial dating data of four fine-grained samples reveal that the syntectonic deposit of ATA initiated at 1.79 ± 0.16 Ma, and the deposit of Xiyu Conglomerate started since 1.67 ± 0.18 Ma. Thus, we suggest that the thrust–folding of ATA began at ca.1.79 Ma and is currently still active.
Effectiveness of Early Advanced Glycation End Product Accumulation Testing in the Diagnosis of Diabetes: A Health Risk Factor Analysis Using the Body Mass Index as a Moderator
Authors: Zhang Yi , Jiang Tian , Liu Chao , Hu Honglin , Dai Fang , Xia Li , Zhang Qiu 
Published: March 2022

ObjectiveTo evaluate the value of non-invasive detection of advanced glycation end products (AGEs) in the early screening of type 2 diabetes mellitus (T2DM) in the community of China.MethodsFrom January 2018 to January 2019, a total of 912 patients with community health physical examination and no history of T2DM were selected, excluding the results of missing value &gt; 5%. Finally, 906 samples were included in the study, with a response rate of 99.3%. Non-invasive diabetic detection technology was used to detect AGEs in the upper arm skin of all participants, AGE accumulations were classified as ≤P25, P25∼P50, P50∼P75, and &gt;P75; HbA1c, insulin, C-peptide, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), creatinine, urea, and other indicators were measured at the same time. Univariate analysis of variance was used to compare the differences in general data, biochemical indexes, skin AGE levels, and blood glucose among groups, and logistic regression analysis and latent category analysis were performed.ResultsIn univariate analysis, SBP, FBG, HbA1c, and age were correlated with higher AGE (p &lt; 0.01); TG, TC, HDL, UA, and gender were not positively correlated with AGE (p &lt; 0.01). After controlling for covariates (waist circumference, hip circumference), AGE accumulation was interacted with other variables. The results of latent category analysis (LCA) showed that the health risk factors (HRFs), including age, systolic blood pressure, HbA1c, FBG, triglyceride, total cholesterol, HDL-C, and uric acid, were divided as three groups, and AGE is divided into four categories according to the quartile method, which were low risk (≤P25), low to medium risk (P25∼P50), medium to high (P50∼P75), and high risk (&gt;P75), respectively. The association between the quartile AGE and risk factors of the OR values was 1.09 (95% CI: 1.42, 2.86), 2.61 (95% CI: 1.11, 6.14), and 5.41 (95% CI: 2.42, 12.07), respectively. The moderation analysis using the PROCESS program was used to analyze whether BMI moderated the link between risk factors and AGE accumulation. There was also a significant three-way interaction among HRFs, BMI, and gender for AGE accumulation in the total sample (β = -0.30).ConclusionNon-invasive skin detection of AGEs has a certain application value for the assessment of T2DM risk and is related to a variety of risk factors.