bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure to detect Schmallenberg virus RNA in ram semen in the UK (2016–2018)
Authors: Curwen Alice , Jones Scott , Stayley Ceri , Eden Laura , McKay Heather , Davies Peers , Lovatt Fiona , Dunham Stephen , Tarlinton Rachael 
Published: June 2022

AbstractBackgroundSchmallenberg virus (SBV) is a midge‐borne arbovirus that first emerged in the European ruminant population in 2011 and has since settled to an endemic pattern of disease outbreaks on an approximately 4‐year cycle when herd immunity from the previous circulation drops to a point allowing renewed widescale virus circulation. The impacts of trade restrictions on genetic products (semen, embryos) from affected areas were severe, particularly after the discovery that the virus is intermittently shed in the semen of a small number of bulls. The trade in small ruminant (ram and goat) semen is less than that of bulls; nonetheless, there has been no study into the shedding rate of SBV in ram semen.MethodsSemen samples (n = 65) were collected as part of UK ram trials and artificial insemination studies around the period of the 2016–2018 SBV recirculation. Semen was preserved in RNAlater for shipping, and RNA extraction with RNeasy and S gene RT‐quantitative PCR performed for SBV nucleic acid detection.ResultsNo SBV RNA was detected in any samples.ConclusionsWhile larger numbers of animals would be needed to completely exclude the possibility of SBV shedding in ram semen, this trial nonetheless highlights that this is likely a rare event if it occurs at all and is unlikely to play a role in disease transmission.
Connecting Forecast and Warning: A Partnership Between Communicators and Scientists
Authors: Anderson Cheryl L. , Rovins Jane , Johnston David M. , Lang Will , Golding Brian , Mills Brian , Kaltenberger Rainer , Chasco Julia , Pagano Thomas C. , Middleham Ross , Nairn John 
Published: June 2022

AbstractIn this chapter, we examine the ways that warning providers connect and collaborate with knowledge sources to produce effective warnings. We first look at the range of actors who produce warnings in the public and private sectors, the sources of information they draw on to comprehend the nature of the hazard, its impacts and the implications for those exposed and the process of drawing that information together to produce a warning. We consider the wide range of experts who connect hazard data with impact data to create tools for assessing the impacts of predicted hazards on people, buildings, infrastructure and business. Then we look at the diverse ways in which these tools need to take account of the way their outputs will feed into warnings and of the nature of partnerships that can facilitate this. The chapter includes examples of impact prediction in sport, health impacts of wildfires in Australia, a framework for impact prediction in New Zealand, and communication of impacts through social media in the UK.
Creep behavior of polyamide 12, produced by selective laser sintering with different build orientations
Authors: Krönert Maximilian , Schuster Thomas Josef , Zimmer Felix , Holtmannspötter Jens 
Published: June 2022

AbstractThe successful use of components produced by selective laser sintering as a rapid manufacturing process requires a comprehensive understanding of the material. In this study, the effect of specimen build orientation on mechanical properties of selective laser-sintered polyamide 12 was investigated in detail. Samples were printed with an orientation of 0°, 15°, 45°, and 90° to the build platform. In addition to quasi-static tensile tests, creep tests under different loads (5 MPa, 10 MPa, 15 MPa, and 20 MPa) and for different times (10 h and 1000 h) with and without relaxation were performed. Creep behavior was analyzed using the Burgers model. Therefore, the elastic strain, the relaxant strain, the viscous strain, and the total deformation were determined. Results show that the build orientation has no significant influence on the long-term creep behavior, at small stresses. Short-term creep and relaxation tests show that the elastic and viscous strain are only slightly influenced by the build orientation. However, the viscoelastic strain is affected by the build orientation. Furthermore, the deformations resulting from creep and relaxation have no significant influence on the mechanical behavior as shown by tensile tests.
The canonical wall structure and intrinsic mirror symmetry
Authors: Gross Mark , Siebert Bernd 
Published: June 2022

AbstractAs announced in Gross and Siebert (in Algebraic geometry: Salt Lake City 2015, Proceedings of Symposia in Pure Mathematics, vol 97, no 2. AMS, Providence, pp 199–230, 2018) in 2016, we construct and prove consistency of thecanonical wall structure. This construction starts with a log Calabi–Yau pair (X, D) and produces a wall structure, as defined in Gross et al. (Mem. Amer. Math. Soc. 278(1376), 1376, 1–103, 2022). Roughly put, the canonical wall structure is a data structure which encodes an algebro-geometric analogue of counts of Maslov index zero disks. These enumerative invariants are defined in terms of the punctured invariants of Abramovich et al. (Punctured Gromov–Witten invariants, 2020.arXiv:2009.07720v2[math.AG]). There are then two main theorems of the paper. First, we prove consistency of the canonical wall structure, so that, using the setup of Gross et al. (Mem. Amer. Math. Soc. 278(1376), 1376, 1–103, 2022), the canonical wall structure gives rise to a mirror family. Second, we prove that this mirror family coincides with the intrinsic mirror constructed in Gross and Siebert (Intrinsic mirror symmetry, 2019.arXiv:1909.07649v2[math.AG]). While the setup of this paper is narrower than that of Gross and Siebert (Intrinsic mirror symmetry, 2019.arXiv:1909.07649v2[math.AG]), it gives a more detailed description of the mirror.
A novel atraumatic extraction technique using vestibular socket therapy for immediate implant placement: a randomized controlled clinical trial
Authors: Ghallab Noha Ayman , Elaskary Abdelsalam , Elsabagh Hossam , Toukhy Abrar El , Abdelrahman Hams , El-Kimary Gillan 
Published: June 2022

Abstract

Purpose
This randomized controlled clinical trial compared soft tissue changes following a novel vestibular atraumatic extraction technique (test group) versus the conventional incisal atraumatic extraction approach (control group) while implementing the vestibular socket therapy for immediate implant placement.

Methods
Thirty patients with hopeless maxillary anterior teeth requiring atraumatic extraction were randomly assigned into two equal groups to receive either test or control. Vertical soft tissue alterations in mm were measured at baseline and 12 months post-restoration using intraoral digital scans at three reference points, distal papilla, mid-facial gingival margin, and mesial papilla, as well as pink esthetic scores (PESs) after 12 months.

Results
Vestibular extraction technique showed significant soft tissue improvement and creeping when compared to incisal extraction (P < 0.05). The test group showed soft tissue measurements with a mean (± SD) of 0.26 (± 0.58), 0.39 (± 0.64), and 0.05 (± 0.37) mm for the mesial papilla, mid-facial gingival margin, and distal papilla respectively. While the incisal extraction technique demonstrated gingival recession at the distal papilla, mid-facial gingival margin, and mesial papilla of − 0.37 (± 0.54) mm, − 0.32 (± 0.68) mm, and − 0.39 (± 0.59) mm respectively. The overall PESs after 12 months were 12.67 (± 1.59) in vestibular extraction group, while incisal extraction group was 11.40 (± 1.40), with significant difference between them (P = 0.03).

Conclusion
This investigation suggests that both studied techniques were successful in the atraumatic extraction of hopeless severely damaged teeth. The novel vestibular extraction technique might be considered an alternative reliable atraumatic extraction approach compared to the conventional incisal extraction when performing the vestibular socket protocol for immediate implant placement with soft tissue enhancement.
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
Authors: Rovas Alexandros , Buscher Konrad , Osiaevi Irina , Drost Carolin Christina , Sackarnd Jan , Tepasse Phil-Robin , Fobker Manfred , Kühn Joachim , Braune Stephan , Göbel Ulrich , Thölking Gerold , Gröschel Andreas , Rossaint Jan , Vink Hans , Lukasz Alexander , Pavenstädt Hermann , Kümpers Philipp 
Published: June 2022

Abstract
Aims
Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose of this study was to compare microvascular injury patterns and proteomic signatures in COVID-19 and bacterial sepsis patients.

Methods and results
This multi-center, observational study included 22 hospitalized adult COVID-19 patients, 43 hospitalized bacterial sepsis patients, and 10 healthy controls from 4 hospitals. Microcirculation and glycocalyx dimensions were quantified via intravital sublingual microscopy. Plasma proteins were measured using targeted proteomics (Olink). Coregulation and cluster analysis of plasma proteins was performed using a training-set and confirmed in a test-set. An independent external cohort of 219 COVID-19 patients was used for validation and outcome analysis. Microcirculation and plasma proteome analysis found substantial overlap between COVID-19 and bacterial sepsis. Severity, but not disease entity explained most data variation. Unsupervised correlation analysis identified two main coregulated plasma protein signatures in both diseases that strictly counteract each other. They were associated with microvascular dysfunction and several established markers of clinical severity. The signatures were used to derive new composite biomarkers of microvascular injury that allow to predict 28-day mortality or/and intubation (area under the curve 0.90, p < 0.0001) in COVID-19.

Conclusion
Our data imply a common biological host response of microvascular injury in both bacterial sepsis and COVID-19. A distinct plasma signature correlates with endothelial health and improved outcomes, while a counteracting response is associated with glycocalyx breakdown and high mortality. Microvascular health biomarkers are powerful predictors of clinical outcomes.

Graphical abstract
Assessing the Legitimacy of Corporate Political Activity: Uber and the Quest for Responsible Innovation
Authors: de los Reyes Gastón , Scholz Markus 
Published: June 2022

AbstractBuilding on literature in political CSR and corporate political activity (CPA) as well as responsible innovation and responsible lobbying, we introduce a framework to assess the legitimacy status of corporate political activity. We focus on the fact that companies frequently face sharp regulatory backlash after penetrating markets with their innovations. In response to regulatory backlash, big tech companies often employ an arsenal of corporate political activities to (re-)shape national and local regulatory environments, which raises the important questions about the legitimacy of CPA tactics that we address. To develop and apply this framework, we briefly survey and then assess Uber’s corporate political activities in its 2015 New York City political campaign.
Governing Queer Histories and Futures: A Critical Place-Based Analysis of State Apology
Authors: Albion Astrid , Russell Emma K. 
Published: June 2022

AbstractThe southern island of Tasmania is renowned for being the last Australian state to decriminalise homosexuality in 1997. Twenty years after the repeal of these laws, the state parliament of Tasmania passed legislation introducing an expungement scheme for historical homosexual convictions and delivered an apology for their harms. In this article, we draw upon theories of sexual citizenship to develop a critical place-based analysis of the Tasmanian apology that is attentive to the specificities of the region’s political, social, and cultural context. We argue that the parliament’s attempts to redefine the boundaries of sexual belonging through apology and expungement entail new forms of erasure, exclusion and policing. The limits of the apology’s liberal discourse of progress are foretold by several tendencies within its narration, including: the persistent impulse to erase both past records of the law’s violence and future LGBTQIA + identities; assumptions of sexual essentialism and biological determinism; and the uneasy demarcation of il/legal sexual practices, which reasserts the state’s authority to govern sexuality through recourse to the criminal law. Our analysis highlights the need for more place-based analysis of emergent modes of sexual governance within queer criminology and for further research into the material benefits, if any, that apologies and expungement schemes provide to those affected.
Asymmetric Information in a Capital Accumulation Differential Game with Spillover and Learning Effects
Authors: Feichtinger Gustav , Hartl Richard F. , Kort Peter M. , Seidl Andrea , Wrzaczek Stefan 
Published: June 2022

AbstractThis paper considers a capital accumulation game where the installation costs of investments are lowered by the firm’s own capital stock because of learning and by the competitor’s capital stock because of spillover effects. To properly understand the impact of the two capital stocks, we consider six information structures which differ in whether a firm takes into account that their competitor’s strategy depends only on time or on one or both capital stocks. We find that if firms are aware that their own capital stock makes investments of the competitor more efficient, a firm would invest less. Due to this effect, information only pays off if it is taken into account by both competitors, because otherwise the less informed and therefore less cautious player invests more and has a higher capital stock and revenues in the long run.
Selenium Alleviates Cerebral Ischemia/Reperfusion Injury by Regulating Oxidative Stress, Mitochondrial Fusion and Ferroptosis
Authors: Shi Yuanyuan , Han Lijian , Zhang Xianxian , Xie Lili , Pan Pinglei , Chen Fei 
Published: June 2022

AbstractTo clarify the potential role of selenium (Se) on cerebral ischemia/reperfusion (I/R) injury, we utilized mouse middle cerebral artery occlusion (MCAO) followed by reperfusion as an animal model and oxygen–glucose deprivation and reoxygenation (OGD/R) to treat N2a cells as a cell model, respectively. MCAO model was established in mice and then divided into different groups with or without Se treatment. TTC staining was used to observe whether the cerebral I/R modeling was successful, and the apoptosis level was determined by TUNEL staining. The expression of GPx-4 and p22phox was assessed by western blot. In vitro experiments, the OGD/R induced oxidative stress in N2a cells was assessed by levels of GSH/GSSG, malondialdehyde, superoxide dismutase and iron content, respectively. QRT-PCR was used to detect the mRNA levels of Cox-2, Fth1, Mfn1 and mtDNA in N2a cells. JC-1 staining and flow cytometry was performed to detect the mitochondrial membrane potential. Se treatment alleviated cerebral I/R injury and improved the survival rate of mice. Additionally, Se treatment apparently attenuated oxidative stress and inhibited iron accumulation in MCAO model mice and OGD/R model of N2a cells. In terms of its mechanism, Se could up-regulate Mfn1 expression to alleviate oxidative stress and ferroptosis by promoting mitochondrial fusion in vivo and vitro. These findings suggest that Se may have great potential in alleviating cerebral I/R injury.
Machine learning and landslide studies: recent advances and applications
Authors: Tehrani Faraz S. , Calvello Michele , Liu Zhongqiang , Zhang Limin , Lacasse Suzanne 
Published: June 2022

AbstractUpon the introduction of machine learning (ML) and its variants, in the form that we know today, to the landslide community, many studies have been carried out to explore the usefulness of ML in landslide research and to look at some classic landslide problems from an ML point of view. ML techniques, including deep learning methods, are becoming popular to model complex landslide problems and are starting to demonstrate promising predictive performance compared to conventional methods. Almost all the studies published in the literature in recent years belong to one of the following three broad categories: landslide detection and mapping, landslide spatial forecasting in the form of susceptibility mapping, and landslide temporal forecasting. In this paper, we present a brief overview of ML techniques, provide a general summary of the landslide studies conducted, in recent years, in the three above-mentioned categories, and make an attempt to critically evaluate the use of ML methods to model landslide processes. The paper also provides suggestions for future use of these powerful data-driven techniques in landslide studies.
Geometrically nonlinear dynamic analysis of the stiffened perovskite solar cell subjected to biaxial velocity impacts
Authors: Bo Luo , Gao Wei , Yu Yuguo , Chen Xiaojun 
Published: June 2022

AbstractThe perovskite solar cell (PSC) is one of the most promising photovoltaic candidates along with the highly increasing demand for green electricity. One of the main concerns regarding the PSC during its service life is nonlinear instability due to ultra-thin structural features and dynamic loadings. This paper presents a framework for nonlinear dynamic and stability analyses of the PSC with oblique stiffeners that are integrated as enhancements against external impacts. Considering von-Kármán geometric nonlinearity and smeared oblique stiffeners, the dynamic governing equation is derived by capitalizing on Airy’s stress function and the Galerkin approach. The deduced nonlinear motion equation can be effectively solved by the fourth-order Runge–Kutta method, such that the natural frequency, wind-induced nonlinear vibration behaviour, and dynamic buckling characteristics of the stiffened PSC can be assessed. The accuracy of the developed framework is verified with established benchmarks. Moreover, the effects of the damping ratio, thermal variance, wind load, compression speed, elastic foundation, initial imperfection, compression ratio, oblique stiffeners, and active layer thickness on the structural response and stability are thoroughly examined. Concluding remarks, drawn from this study, on the mechanical performance and stability of the novel PSC will benefit the practical design and application of PSC energy harvesting devices.
Clinical and radiographic assessment of peripheral joints in controlled acromegaly
Authors: Pelsma Iris C. M. , Kroon Herman M. , van Trigt Victoria R. , Pereira Alberto M. , Kloppenburg Margreet , Biermasz Nienke R. , Claessen Kim M. J. A. 
Published: June 2022

Abstract
Purpose
Acromegalic arthropathy is a well-known phenomenon, occurring in most patients regardless of disease status. To date, solely hips, knees, hands, and spinal joints have been radiographically assessed. Therefore, this study aimed to assess the prevalence of joint symptoms and radiographic osteoarthritis (OA) of new, and established peripheral joint sites in well-controlled acromegaly.

Methods
Fifty-one acromegaly patients (56% female, mean age 64 ± 12 years) in long-term remission for 18.3 years (median, IQR 7.2–25.4) were included. Nineteen patients currently received pharmacological treatment. Self-reported joint complaints were assessed using standardized interviews. Self-reported disability of the upper and lower limbs, and health-related quality of life (HR-QoL) were evaluated using validated questionnaires. Radiographic OA [defined as Kellgren & Lawrence (KL) ≥ 2] was scored using (modified) KL methods.

Results
Radiographic signs of OA were present in 46 patients (90.2%) with ≥ 2 joints affected in virtually all of these patients (N = 44; 95.7%). Radiographic MTP1 OA was as prevalent as radiographic knee OA (N = 26, 51.0%), and radiographic glenohumeral OA was similarly prevalent as hip OA [N = 21 (41.2%) vs. N = 24 (47.1%)]. Risk factors for radiographic glenohumeral OA were higher pre-treatment IGF-1 levels [OR 1.06 (1.01–1.12), P = 0.021], and current pharmacological treatment [OR 5.01 (1.03–24.54), P = 0.047], whereas no risk factors for MTP1 joint OA could be identified.

Conclusion
Similar to previously-assessed peripheral joints, clinical and radiographic arthropathy of the shoulder and feet were prevalent in controlled acromegaly. Further studies on adequate management strategies of acromegalic arthropathy are needed.
Robust and accurate regression-based techniques for period inference in real-time systems
Authors: Vădineanu Şerban , Nasri Mitra 
Published: June 2022

AbstractWith the growth in complexity of real-time embedded systems, there is an increasing need for tools and techniques to understand and compare the observed runtime behavior of a system with the expected one. Since many real-time applications require periodic interactions with the environment, one of the fundamental problems in guaranteeing their temporal correctness is to be able to infer the periodicity of certain events in the system. The practicability of a period inference tool, however, depends on both its accuracy and robustness (also its resilience) against noise in the output trace of the system, e.g., when the system trace is impacted by the presence of aperiodic tasks, release jitters, and runtime variations in the execution time of the tasks. This work (i) presents the first period inference framework that uses regression-based machine-learning (RBML) methods, and (ii) thoroughly investigates the accuracy and robustness of different families of RBML methods in the presence of uncertainties in the system parameters. We show, on both synthetically generated traces and traces from actual systems, that our solutions can reduce the error of period estimation by two to three orders of magnitudes w.r.t. the state of the art.
Linking Friction Scales from Nano to Macro via Avalanches
Authors: Salners Tyler , Curry John F. , Hinkle Adam R. , Babuska Tomas F. , Argibay Nicolas , DelRio Frank W. , Chandross Michael , Dahmen Karin 
Published: June 2022

AbstractSteady-state fluctuations in the friction force of molybdenum disulfide (MoS2), a prototypical lamellar solid, were analyzed experimentally for newton-scale forces and computationally via molecular dynamics simulations for nanonewton-scale forces. A mean field model links the statics and the dynamics of the friction behavior across these eight orders of magnitude in friction force and six orders of magnitude in friction force fluctuations (i.e., avalanches). Both the statistics and dynamics of the avalanches match model predictions, indicating that friction can be characterized as a series of avalanches with properties that are predictable over a wide range of scales.