bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Stratification to Predict Renal Survival in Anti–Glomerular Basement Membrane Disease
Authors: Floyd Lauren , Bate Sebastian , Hadi Kafagi Abdul , Brown Nina , Scott Jennifer , Srikantharajah Mukunthan , Myslivecek Marek , Reid Graeme , Aqeel Faten , Frausova Doubravka , Kollar Marek , Kieu Phuong Le , Khurshid Bilal , Dhaygude Ajay , Tesar Vladimir , McAdoo Stephen , Little Mark A. , Geetha Duvuru , Brix Silke R. 
Published: November 2022

Background
Prospective randomized trials investigating treatments and outcomes in anti–glomerular basement membrane (anti-GBM) disease are sparse, and validated tools to aid prognostication or management are lacking.

Methods
In a retrospective, multicenter, international cohort study, we investigated clinical and histologic parameters predicting kidney outcome and sought to identify patients who benefit from rescue immunosuppressive therapy. We also explored applying the concept of the renal risk score (RRS), currently used to predict renal outcomes in ANCA-associated vasculitis, to anti-GBM disease.

Results
The final analysis included 174 patients (out of a total of 191). Using Cox and Kaplan–Meier methods, we found that the RRS was a strong predictor for ESKD. The 36-month renal survival was 100%, 62.4%, and 20.7% in the low-risk, moderate-risk, and high-risk groups, respectively. The need for renal replacement therapy (RRT) at diagnosis and the percentage of normal glomeruli in the biopsy were independent predictors of ESKD. The best predictor for renal recovery was the percentage of normal glomeruli, with a cut point of 10% normal glomeruli providing good stratification. A model with the predictors RRT and normal glomeruli (N) achieved superior discrimination for significant differences in renal survival. Dividing patients into four risk groups led to a 36-month renal survival of 96.4% (no RRT, N≥10%), 74.0% (no RRT, N<10%), 42.3% (RRT, N≥10%), and 14.1% (RRT, N<10%), respectively.

Conclusions
These findings demonstrate that the RRS concept is transferrable to anti-GBM disease. Stratifying patients according to the need for RRT at diagnosis and renal histology improves prediction, highlighting the importance of normal glomeruli. Such stratification may assist in the management of anti-GBM disease.
Multinodular gastro intestinal stromal tumor in small intestine with perforation and Meckel’s diverticulitis- An unusual presentation
Authors: Mishra Himachal , Alexander Manika 
Published: November 2022

Gastrointestinal Stromal tumor are rare group of mesenchymal neoplasms originating from the wall of the digestive tract. Outcome strongly dependent on tumor size and mitotic activity. A 60-year male presented with abdominal pain and distention for 3 months. After initial evaluation, emergency laparotomy was done. Intraoperatively found to have multiple small nodules in peritoneum and mesenteric border of small intestine and rupture of a big nodule was observed causing peritonitis. Gross examination-Multiple nodular tumour mass in small intestine along with multiple haemorrhagic nodule of varying size seen in mesentry. Tumor arising from muscular layer arranged in interlacing fascicles, bundles, whorls and sheets. Tumor cells are elongated having spindle to elongated nucleus with vesicular to dense chromatin and inconspicuous nucleoli. Some of the nodules shows areas of haemorrhage and necrosis. Mitotic figure &#62; 5/50 HPF seen. Histological grade-G2 High grade &#62;5/50 HPF, TNM grade-PT4PNxPMx. Immunohistochemistry-Diffusely Positive for CD117. Focally positive for DOG1, CD34 & SMA. Small intestinal GISTs comprise approximately 30% of all GISTs. Tumor size vary from small nodules to complex masses of around 20 cm. GIST is more common in patients with age &#62;40 years. CD117 and DOG1 positivity are used to define these tumors. Novelty: Only few cases has been reported in small bowel GIST with perforation and multiple nodules.
Comparison of Two Different Electro Polish Temperature on Cobalt Ion Release of Chromium Cobalt Alloy in Artificial Saliva with Atomic Absorption Spectrophotometry
Authors: Adib Amir , Mahabadi Meysam , Rashidi Meybodi Fatemeh , Alehi Abari Sayed Mohammad Mehdi S 
Published: November 2022

Introduction: Metals are widely used in direct and indirect restorative materials, both in prosthetics and orthodontics. The biocompatibility of these metals depends on their chemical nature, the number of ions released, and the period of contact of these metals. This study aims to compare two different electropolish temperatures on the release of cobalt ion from chromium-cobalt alloy.
Materials & Methods: In this experimental study, 24 wax patterns were cut in the form of a circle with a diameter of 15 mm and a thickness of 1 mm. Then, the samples were sprued and invested. Burn out and casting were used to cast the alloy. The samples were sandblasted and polished with aluminum oxide. They were randomly divided into two 12-number groups and electropolished at 45° and 55° C. Samples were placed in artificial saliva and sent to atomic absorption spectrophotometer for 15 and 30 days to read the cobalt. Data were then analyzed by Independent t-test and Paired t-test (p value = 0.05).
Results: The average release of cobalt from chromium cobalt alloy on the 30th day was higher than the 15th day at both 45°C and 55°C. This difference was significant at 45°C (p value = 0.036) while not significant at 55°C (p value = 0.0754). Regarding the comparison of the ion release at 45° and 55°C, the difference was not significant on the 15th day (p value = 0.067) and 30th day (p value = 0.0754).
Conclusion: The amount of cobalt ions released from the cobalt-chromium alloy at 45°C is fewer than at 55°C over time.
Relationship between Personality Factors and Cooperation in Adult Patients Candidates for Fixed Orthodontic Treatment in Isfahan
Authors: Akhlaghi Alireza , Monirifrard Mohammad , Nikbakht Mohammad Hossein , Shirban Farinaz 
Published: November 2022

Introduction: Cooperation is one of the most important predictors of treatment outcome in orthodontics. Lack of cooperation can cause prolonged treatment, decrease of efficiency, unpredictable outcome, and cost increase. In this study, the relationship between some personality traits of patients and their cooperation in orthodontic treatment was investigated.
Materials & Methods: In this cross-sectional descriptive-analytical study, 90 patients who had been referred to 7 specialized orthodontic centers in Isfahan for treatment in 2018 were selected by convenience cluster sampling method. Five personality traits of patients were extracted by NEO-Five Factor Inventory personality test, and their level of cooperation between 2 months and 6 months was extracted by Orthodontic Patient Cooperation Scale questionnaire. The correlation between personality factors and the amount of cooperation in both intervals was calculated by Pearson correlation coefficient analysis. The significance level was considered at 0.05.
Results: There is a significant correlation between neuroticism and patients' cooperation in 2 months and 6 months with coefficients of 0.25 and 0.24, respectively. (p value = 0.01 and p value = 0.03, respectively) There is also a correlation between conscientiousness and cooperation in 6 months with a coefficient of 0.28 (p value = 0.01).
Conclusion: It seems that neurotic personality factor can be a risk factor in patients' lack of cooperation in orthodontic treatment. Conscientiousness is also a factor that can predict good cooperation in orthodontic treatment. But these correlations are not very strong.
Empathy! So What?
Authors: Konecki Krzysztof T. 
Published: November 2022

The paper deals with the concept of empathy applied in the contemplative experiment to understand the suffering of the victims of the war in Ukraine. I discuss the concept of empathy in the phenomenological perspective and symbolic interactionists’ view. I needed this discussion to frame the conclusions from the contemplative experiment I did with my students. I used the contemplative methods of research. The students did self-observations and self-reports on their lived experiences while observing photos of the victims and refugees from Ukraine. Breathing exercises (pranayama) were practiced between different self-observations to clean the minds and release tensions. At the end of the experiment, the students were also asked about the empathy deficit in contemporary society, and provided comments on it. Finally, I concluded how empathy is evoked and embodied, and I answered the question about whether it is possible to be empathetic toward people in a totally different and traumatic situation. I end with the statement that empathy is a direct reaction to the condition of the suffering of other people. However, it is also socially-framed. I conclude that it could be socially-developed to cope with an empathy deficit.
ВЛИЯНИЕ СТРУКТУРЫ БЕНТОНИТОВОЙ ГЛИНЫ, АКТИВИРОВАННОЙ ДАВЛЕНИЕМ, НА ПОКАЗАТЕЛЬ АДСОРБЦИИ
Authors: Середин Валерий Викторович , Алванян Карине Антоновна , Маковецкий Олег Александрович , Ядзинская Марина Радиковна 
Published: November 2022

Актуальность. Полученные результаты исследования позволяют разработать технологию улучшения
адсорбционной активности глин и получение модифицированных образцов глин с необходимыми
адсорбционными свойствами, применяемых для устройства противофильтрационных экранов и завес, гидроизоляционного материала полигонов хранения промышленных и бытовых отходов, новых фармацевтических композиций лекарственных средств, в том числе для технологии твердых
лекарственных форм, а также добавок в пищевые подкормки для животных с высокими сорбционными характеристиками.
Цель: оценка влияния структуры и свойств порового раствора на адсорбцию бентонитовой глины,
активированной давлением.
Объект: обогащенная бентонитовая глина, активированная давлением до 800 МПа.
Методы. Обработку информации осуществляли геологическими и вероятностно-статистическими
методами.
Результаты. При активации глин давлением до 150 МПа наибольшее влияние на ее адсорбцию
оказывает энергетический потенциал коллоида; при увеличении давления до 800 МПа – энергетический потенциал поверхности минерала, то есть энергетический потенциал структурного элемента более низкого уровня. Следующим по степени воздействия показателем является водородный показатель порового раствора глины. Другие показатели, в том числе и площадь удельной поверхности пор, увеличивающаяся на 25 м2/г, имеют подчиненное значение. Предложена методика обработки информации, основанная на многомерном пошаговом регрессионном анализе, позволяющая ранжировать исследуемые показатели по степени их влияния на адсорбционную активность глины. Разработаны математические модели, позволяющие прогнозировать адсорбционную активность обработанных давлением глин по водяному пару.
ИССЛЕДОВАНИЯ ПО ЛАЗЕРНОЙ ДЕЗАКТИВАЦИОННОЙ ОЧИСТКЕ ПОВЕРХНОСТЕЙ МЕТАЛЛОВ, ЗАГРЯЗНЕННЫХ РАДИОАКТИВНЫМИ МАТЕРИАЛАМИ
Authors: Софронов Владимир Леонидович , Карташов Евгений Юрьевич , Ткачук Семён Александрович , Пак Александр Дмитриевич , Тинин Василий Владимирович , Галата Андрей Александрович 
Published: November 2022

Актуальность исследования обусловлена необходимостью поиска нового, более эффективного, метода дезактивации больших объемов металлических отходов, загрязненных радиоактивными веществами. Накопление такого вида отходов связано с производством и последующим сокращением ядерных боезарядов, демонтажем отработавших ресурс объектов атомной промышленности и неядерного сектора.
Цель: проведение исследований по дезактивационной очистке металлических поверхностей,
загрязненных радиоактивными материалами, с использованием передвижной лазерной установки
модульного типа.
Объекты: системы, состоящие из образцов различных металлов и связанных с ними слоев покрытий
различной морфологии (слой коррозии, лакокрасочного покрытия, смазки), загрязненных
радиоактивными веществами, а также лазерное излучение.
Методы: лазерная деактивация (установка «HTF Clean 500»), радиометрический анализ (МКС-01А
«МУЛЬТИРАД» и МКС-АТ-1117М), оптическая микроскопия (Miсromed Polar Nikon SMZ745T), фотофиксация (Sony α-6000), сканирующая электронная микроскопия (Carl Zeiss Sigma), шлифовальный
и обрезной инструменты, электронные весы (СПВ-60), линейный измерительный инструмент.
Результаты. Разработаны методики проведения исследований процесса лазерной дезактивации
металлических поверхностей, загрязненных радиоактивными веществами и дозиметрических
исследований образцов металлических поверхностей до и после их лазерной обработки. Определены
оптимальные параметры процесса лазерной дезактивации поверхностей различной морфологии и
состава; построены графики зависимостей степени удаляемого загрязнения различной морфологии и
состава от числа проходов лазерной дезактивации; сделаны выводы о целесообразности использования метода лазерной очистки для обработки металлов, содержащих на поверхности радиоактивные вещества, и даны рекомендации по проведению процесса лазерной дезактивации для различных металлических отходов, загрязненных радиоактивными веществами.
IMPROVING SUCKER ROD PUMP EFFICIENCY USING FREQUENCY CONTROLLED INDUCTION MOTOR
Authors: Текле Самуэль Исаак , Зюзев Анатолий Михайлович , Костылев Алексей Васильевич 
Published: November 2022

Relevance. In sucker rod pump installations, the cost of the prime mover’s power use has substantial effect on the overall operational cost. Reduction in power consumption can lead to reduction in operating cost. Hence, as the sucker rod pump is dominant in the oil industry, any means which reduces the energy consumption can produce considerable economic benefit and help to meet the energy efficiency targets and standards. Due to the losses in the prime mover, surface transmission, and sucker rod string the power required to lift oil to the surface is always less than the power input to the prime mover. Induction motors, which are widely used as prime movers in sucker rod pump installations, operate at significantly lower efficiency and at a load lower than their rated capacity. Therefore, the demand for efficiency improvement is readily seen. This demand can be achieved by controlling motor losses through AC-DC-AC converter. The main aim of the research is to develop control strategy that helps to operate the sucker rod pump drive at optimal efficiency. Objects: electrical drive, sucker rod pump, oil producing well. Method: integrated simulation model consisting of the models of AC-DC-AC converter, induction motor including iron loss, sucker rod pump; vector control; generation of optimal magnetizing current trajectory for one cycle of pump operation. Result. The energy consumption of sucker rod pump unit for operation at rated flux and the one based on optimal magnetizing current trajectory were compared using an integrated simulation model. The simulation results indicate that about 1,6 % of the required energy can be saved when the sucker rod pump is operated based on the calculated optimal magnetizing current trajectory.
Complex Aesthetic Treatment of Patients with Multiple Caries
Authors: Eka Juniarti Devi , Yuanita Tamara , Pribadi Nirawati , Marbun Tarsardo , Sekar Pramesti Nadien 
Published: November 2022

Background: The need for dental esthetics is very important in recent years. Fulfilling aesthetic demands with both non-invasive and minimally invasive techniques can maintain tissue continuity. A 38 year old female patient came to the clinic with an esthetic complaint of maxillary anterior teeth. The following case report describes a step by step complex aesthetic treatment of a patient with multiple caries. Appealing aesthetic results will restore the patient's smile through restorative treatment in dentistry. Purpose: The purpose of this case report is to explain the management of complex aesthetic treatment of patients with multiple caries Case: A 38-year-old female patient complained her upper front teeth is turning black. The patient complained that her teeth had hurt ± 3 months ago and sometimes felt sore. The patient wants her teeth to be treated because she feels less confident when she smiles and wants to fix these teeth. The history of treatment on the tooth in question have had root canal treatment and been filled since 8 years ago. The tooth has had braces (orthodontic) treatment and was removed ± 7 years ago. The patient stated that she had no systemic health disorder. Case management : The treatment of this complex case were done using root canal treatment, endodontic retreatment, direct and indirect veneer, dowel, and crown. Conclusion: complex aesthetic treatment of patients with multiple were done aiming for good aesthetic result
Management of Root Perforation : A Case Report
Authors: Paulina Panggono Sylvia , Chairil Hafiz Teuku , Yuanita Tamara 
Published: November 2022

Background : Root perforation results in the communication between root canal walls and periodontal space (external tooth surface). It is commonly caused by an operative procedural accident or pathological alteration (such as extensive dental caries, and external or internal inflammatory root resorption). The diagnosis of dental pulp and/or periapical tissue previous to root perforation is an important predictor of prognosis. Case : A female patient came to Dental Conservative University of Airlangga with complaints of perforated lower left molars. On the objective examination obtained negative vitality test, positive on bite test. On radiographic examination, a radiolucent on bifurcation was performed Case management : The tooth was treated by hemisection. Root canal treatment was carried out in the distal canals. Afterwards, the tooth was split mesio-distally. The mesial root was extracted, and the distal root was retained and restored with PFM Crown. Discussion : Hemisection is a useful alternative treatment to extraction to save the multi-rooted teeth by endodontic approach, which includes the root canal treatment of the remaining roots and restoring them with suitable restorative material to splinting it with the adjacent tooth to decrease the risk of displacement followed by a fixed prosthodontic prosthesis to maintain the occlusal balance. Conclusion : Hemisection with subsequent prosthetic rehabilitation can be a viable alternative to retain severely decayed mandibular molar.
Storms and deforestation prior to Triassic – Jurassic Boundary? Evidence from woody fossils at upmost Xujiahe Formation, Southwestern China
Authors: Zeng Jianli , Zhang Tingshan , Popa Mihai Emilian , Wang Yongdong , Li Liqin , Xu Yuanyuan , Lu Ning , Zhang Xiaoqing 
Published: November 2022

AbstractGlobal climate and environmental changes were the main causes of the end-Triassic mass extinction. However, direct sedimentological evidence of environmental catastrophes is rare in Triassic – Jurassic interval, especially in the eastern Tethys region. The newly discoveredin-situtrunk fossils in paleosol surface and a set of unique branch-supported sandstones below may record the environmental disaster at the Triassic-Jurassic interval in the northern Sichuan Basin. Sedimentological data showed the strong storm prevalent induced the lodging direction of in-situ trunks is opposite to the direction of paleocurrent. Enhancement of large-scale runoff along with the dramatic increase of woody detrital input may indicate the deforesting at the Triassic -Jurassic boundary in eastern Tethys, Sichuan Basin.
Priming mesenchymal stromal cells with neurotrophic factors boosts the neuro-regenerative potential of their secretome
Authors: Teli Prajakta , Nachanekar Aditya , Kale Vaijayanti , Vaidya Anuradha 
Published: November 2022

Abstract

Aim: To explore the neuroprotective potential of the secretome (conditioned medium, CM) derived from neurotrophic factors-primed mesenchymal stromal cells (MSCs; primed CM) using an endoplasmic reticulum (ER) stress-induced in vitromodel system.
Methods: Establishment of ER-stressed in vitro model, immunofluorescence microscopy, real-time PCR, western blot.
Results: Exposure of ER-stressed Neuro-2a cells to the primed-CM significantly restored the neurite outgrowth parameters and improved the expression of neuronal markers like Tubb3 and Map2a in them compared to the naïve CM. Primed CM also suppressed the induction of apoptotic markers Bax and Sirt1, inflammatory markers Cox2 and NF-κB, and stress kinases such as p38 and SAPK/JNK in the stress-induced cells.
Conclusion: The secretome from primed MSCs significantly restored ER stress-induced loss of neurogenesis.
Estimated Impact of Oral Nirmatrelvir;Ritonavir on Reductions in Hospitalizations and Associated Costs within High-Risk COVID-19 Patients in the US
Authors: Sandin Rickard , Harrison Cale , Draica Florin , Wiemken Timothy Lee , Ma Cuiying , Fusco Manuela Di , Markson Leona , Dzingina Mendwas 
Published: November 2022

AbstractBackgroundSARS-CoV-2 (COVID-19) virus is estimated to cost the United States (US) economy trillions of dollars over the next decade. Mass immunization has played a major role in reducing morbidity and mortality related to COVID-19 in the US, but the high-risk population remains vulnerable to developing severe COVID-19. A large clinical trial and several real-world evidence (RWE) studies have demonstrated the effectiveness of nirmatrelvir; ritonavir in reducing hospitalizations or death in high-risk patients. This study aimed to estimate the economic impact of using nirmatrelvir; ritonavir in a high-risk US population infected with COVID-19 as measured by reduction in hospitalizations and associated costs during a time of Omicron predominance.MethodsAn economic model was developed to estimatethe impact of nirmatrelvir; ritonavir in reducing hospitalizations and associated costs from a healthcare perspective. The model compared nirmatrelvir; ritonavir with no treatment in the outpatient setting among patients with mild-to-moderate COVID-19 at high-risk of progressing to severe disease as consistent with the EPIC-HR trial. Hospitalization rate reductions were derived from recent RWE studies conducted during the Omicron period while costs were gathered from the literature. A simulated population of 100,000 COVID-19 patients was modelled and was restricted to patients ≥12 years of age. Sensitivity analyses applied alternative model assumptions.ResultsResults from the model showed that treatment with nirmatrelvir; ritonavir was associated with fewer hospitalizations compared to no treatment, 3,269 vs 6,134 per 100,000 patients, respectively, with a reduction of 2,865 hospitalizations per 100,000 patients and an estimated cost savings of $133,754,359 per 100,000 patients ($152,634,256 for nirmatrelvir; ritonavir and $286,388,614 for no treatment). Varying the rate of hospitalization by 10% showed similar results.ConclusionTreatment with nirmatrelvir; ritonavir during the Omicron period could result in substantial cost savings due to reduction in hospitalizations. This is an important outcome measure that will help reduce the devastating economic burden that COVID-19 has imposed on the US health care system.