bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric Urgent Care Providers' Approach to Antibiotic Stewardship
Authors: Hamdy Rana F. , Nedved Amanda , Fung Melody , Fleming-Dutra Katherine E. , Liu Cindy M. , Obremskey Jill , Montalbano Amanda 
Published: June 2022

Background
Outpatient antibiotic prescribing for acute respiratory conditions is highest in urgent care settings; however, this has not been studied among pediatric urgent cares. The objective of this study was to evaluate pediatric urgent care providers' perceptions of antibiotic stewardship.

Methods
Members of the Society for Pediatric Urgent Care were recruited via email to participate in a quality improvement antibiotic stewardship project. A preimplementation survey was sent to participants via email in March 2019 to evaluate perceptions on antibiotic stewardship. Descriptive statistics were used to analyze the survey responses.

Results
A total of 156 providers completed the survey; 83% were board-certified pediatricians. Almost all (98%) indicated that antibiotic stewardship interventions are important for optimizing antibiotic use in urgent care. More than half (53%) indicated that their urgent care provided guidelines for prescribing antibiotics for acute respiratory tract infections. Treating patients with an underlying complex medical condition was the most common reason (21%) providers would deviate from guidelines. The most commonly cited barriers to appropriate prescribing for acute respiratory infections were patient expectations (93%), psychosocial barriers (40%), lack of clear evidence-based recommendations (15%), and lack of access to guidelines on prescribing (15%).

Conclusions
Parental expectation of receiving antibiotics was viewed as the most common barrier to appropriate prescribing. These findings should be used to target directed interventions such as shared decision making and communication training to support appropriate antibiotic prescribing in pediatric urgent care.
Survival of Locally Advanced MSI-high Gastric Cancer Patients Treated With Perioperative Chemotherapy
Authors: Vos Elvira L. , Maron Steven B. , Krell Robert W. , Nakauchi Masaya , Fiasconaro Megan , Capanu Marinela , Walch Henry S. , Chatila Walid K. , Schultz Nikolaus , Ilson David H. , Janjigian Yelena Y. , Ku Geoffrey Y. , Yoon Sam S. , Coit Daniel G. , Vanderbilt Chad M. , Tang Laura H. , Strong Vivian E. 
Published: June 2022

Objective:
To evaluate the efficacy of chemotherapy in patients with microsatellite instability (MSI)-high gastric cancer.

Background:
Although MSI-high gastric cancer is associated with a superior prognosis, recent studies question the benefit of perioperative chemotherapy in this population.

Methods:
Locally advanced gastric adenocarcinoma patients who either underwent surgery alone or also received neoadjuvant, perioperative, or adjuvant chemotherapy between 2000 and 2018 were eligible. MSI status, determined by next-generation sequencing or mismatch repair protein immunohistochemistry, was determined in 535 patients. Associations among MSI status, chemotherapy administration, overall survival (OS), disease-specific survival, and disease-free survival were assessed.

Results:
In 535 patients, 82 (15.3%) had an MSI-high tumor and ∼20% better OS, disease-specific survival, and disease-free survival. Grade 1 (90%–100%) pathological response to neoadjuvant chemotherapy was found in 0 of 40 (0%) MSI-high tumors versus 43 of 274 (16%) MSS. In the MSI-high group, the 3-year OS rate was 79% with chemotherapy versus 88% with surgery alone (P=0.48). In the MSS group, this was 61% versus 59%, respectively (P=0.96). After multivariable interaction analyses, patients with MSI-high tumors had superior survival compared with patients with MSS tumors whether given chemotherapy (hazard ratio=0.53, 95% confidence interval: 0.28–0.99) or treated with surgery alone (hazard ratio=0.15, 95% confidence interval: 0.02–1.17).

Conclusions:
MSI-high locally advanced gastric cancer was associated with superior survival compared with MSS overall, despite worse pathological chemotherapy response. In patients with MSI-high gastric cancer who received chemotherapy, the survival rate was ∼9% worse compared with surgery alone, but chemotherapy was not significantly associated with survival.
The Mycophenolate-based Immunosuppressive Regimen Is Associated With Increased Mortality in Kidney Transplant Patients With COVID-19
Authors: Requião-Moura Lúcio R. , Modelli de Andrade Luís Gustavo , de Sandes-Freitas Tainá Veras , Cristelli Marina Pontello , Viana Laila Almeida , Nakamura Mônica Rika , Garcia Valter Duro , Manfro Roberto Ceratti , Simão Denise Rodrigues , Almeida Ricardo Augusto Monteiro de Barros , Ferreira Gustavo Fernandes , Costa Kellen Micheline Alves Henrique , de Lima Paula Roberta , Pacheco-Silva Alvaro , Charpiot Ida Maria Maximina Fernandes , Deboni Luciane Mônica , Ferreira Teresa Cristina Alves , Mazzali Marilda , Calazans Carlos Alberto Chalabi , Oriá Reinaldo Barreto , Tedesco-Silva Hélio , Medina-Pestana José ,   on behalf of the COVID-19-KT Brazil Study Group*
Published: June 2022

Background.
The chronic use of immunosuppressive drugs is a key risk factor of death because of coronavirus disease 2019 (COVID-19) in kidney transplant recipients (KTRs), although no evident association between the class of immunosuppressive and outcomes has been observed. Thus, we aimed to compare COVID-19–associated outcomes among KTRs receiving 3 different immunosuppressive maintenance regimes.

Methods.
This study included data from 1833 KTRs with COVID-19 diagnosed between March 20 and April 21 extracted from the national registry before immunization. All patients were taking calcineurin inhibitor associated with mycophenolate acid (MPA, n = 1258), azathioprine (AZA, n = 389), or mammalian targets of rapamycin inhibitors (mTORi, n = 186). Outcomes within 30 and 90 d were assessed.

Results.
Compared with patients receiving MPA, the 30-d (79.9% versus 87.9% versus 89.2%; P < 0.0001) and 90-d (75% versus 83.5% versus 88.2%; P < 0.0001) unadjusted patient survivals were higher in those receiving AZA or mTORi, respectively. Using adjusted multivariable Cox regression, compared with patients receiving AZA, the use of MPA was associated with a higher risk of death within 30 d (adjusted hazard ratio [aHR], 1.70; 95% confidence interval [CI], 1.21-2.40; P = 0.003), which was not observed in patients using mTORi (aHR, 0.78; 95% CI, 0.45-1.35; P = 0.365). At 90 d, although higher risk of death was confirmed in patients receiving MPA (aHR, 1.46; 95% CI, 1.09-1.98; P = 0.013), a reduced risk was observed in patients receiving mTORi (aHR, 0.59; 95% CI, 0.35-0.97; P = 0.04) compared with AZA.

Conclusions.
This national cohort data suggest that, in KTRs receiving calcineurin inhibitor and diagnosed with COVID-19, the use of MPA was associated with higher risk of death, whereas mTORi use was associated with lower risk of death.
Precision 1070 nm Ultrafast Laser-induced Photothrombosis (PLP) of Depth-targeted Vessels in vivo
Authors: Zhu Liang , Wang Mengqi , Fu Peng , Liu Yin , Zhang Hequn , Roe Anna Wang , Xi Wang 
Published: June 2022

AbstractThe cerebrovasculature plays an essential role in neurovascular and homeostatic functions in health and disease conditions. Many efforts have been made for developing vascular thrombosis methods to study vascular dysfunction in vivo, while technical challenges remain, such as accuracy and depth-selectivity to target single vessel in the cerebral cortex. Herein, we first demonstrates the evaluation and quantification of the feasibility and effects of Rose Bengal (RB)-induced photothrombosis with 720-1070 nm ultrafast lasers in raster scan. A flexible and reproducible approach is then proposed to employ a 1070 nm ultrafast laser with spiral scan for producing RB-induced occlusion, which is described as precision ultrafast laser-induced photothrombosis (PLP). Combine with two-photon microscopy imaging, this PLP displays highly precise and fast occlusion induction of various vessel types, sizes, and depths, which enhances the precision and power of the photothrombosis protocol. Overall, the PLP method provides a real-time, practical, precise, and depth-selected single-vessel photothrombosis technology in cerebral cortex with commercially available optical equipment, which is crucial for exploring brain vascular function with high spatial temporal resolution in brain.
PRPF31 interacts with PRPH2 confirmed by co-immunoprecipitation and co-localization
Authors: Xiao Xiaoqiang , Ling Fangyi , Chen Chongbo , Liang Jiajian , Cao Yingjie , Xu Yanxuan , Chen Haoyu 
Published: June 2022

AbstractPurposeTo investigate the potential interaction between PRPF31 and PRPH2.MethodsHEK293T and human retinal pigment epithelial cells 19 (APRE-19) were used for our experiments. eGFP and mCherry reporter expression vectors were constructed for PRPF31 and PRPH2, respectively. Immunoblotting and co-immunoprecipitation (Co-IP) were used for gene expression validation and protein interaction. Immunofluorescence staining assay was used to test the co-localization analysis of PRPF31 and PRPH2.ResultsPRPF31-eGFP and PRPH2-mcherry were highly expressed in HEK293T and APRE-19 cells on fluorescence microscopy and western blot. Co-IP experiments showed that PRPF31 could be pulled down with an anti-PRPH2 antibody. There was co-localization between PRPF31 and PRPH2 in HEK293T, APRE-19 and mouse retina.ConclusionCo-IP and co-localization experiments suggest that PRPF31 interacted with PRPH2.
The mitochondrial genome of the red icefish (Channichthys rugosus) casts doubt on its species status
Authors: Muschick Moritz , Nikolaeva Ekaterina , Rüber Lukas , Matschiner Michael 
Published: June 2022

AbstractAntarctic notothenioid fishes are recognized as one of the rare examples of adaptive radiation in the marine system. Withstanding the freezing temperatures of Antarctic waters, these fishes have diversified into over 100 species within no more than 10-20 million years. However, the exact species richness of the radiation remains contested. In the genus Channichthys, between one and nine species are recognized by different authors. To resolve the number of Channichthys species, genetic information would be highly valuable; however, so far, only sequences of a single species, C. rhinoceratus, are available. Here, we present the nearly complete sequence of the mitochondrial genome of C. rugosus, obtained from a formalin-fixed museum specimen sampled in 1974. This sequence differs from the mitochondrial genome of C. rhinoceratus in no more than 27 positions, suggesting that the two species may be synonymous.
Aspartate reduces liver inflammation and fibrosis by suppressing the NLRP3 inflammasome pathway via upregulating NS3TP1 expression
Authors: Zhou Li , Zhao Jing , Han Ming , Liu Shunai , Yuan Xiaoxue , Ma Anlin , Yang Song , Zeng Yilan , Cheng Jun 
Published: June 2022

AbstractAspartate (Asp) can act on liver Kupffer cells, inhibit NOD-like receptor-P 3 (NLRP3) inflammatory bodies, and improve liver inflammation in acute hepatitis. However, the effect of Asp on the role of hepatic stellate cells (HSCs) in the pathogenesis of liver fibrosis in chronic liver injury remains unexplored. This study aimed to investigate the effects of Asp on CCl4-induced liver fibrosis in mice and HSCs via the NF-κB/ NLRP3 signaling pathway. Liver fibrosis was induced in C57BL/6J mice by intraperitoneally (IP) injecting 0.5 mL/kg 2% CCl4 three times weekly for 8 weeks. Asp was administered to mice by gavage once every morning for 4 weeks. Masson’s trichrome staining, Sirius red staining and hematoxylin and eosin staining were used to detect and analyze the pathological changes in liver tissues. Western blot analysis and immunohistochemistry were applied to determine the protein expression levels of α-smooth muscle actin (α-SMA), collagen III (COL III), NLRP3, and IL-1β. Also, reverse transcription-quantitative PCR was performed to detect the mRNA expression levels. In the liver fibrosis model, the pathological changes in liver tissues improved following treatment with Asp. A marked decrease was observed in protein and mRNA expression levels of α-SMA, COL III, NLRP3, and IL-1β. In addition, HSCs were treated with Asp. The expression levels of α-SMA, COL III, NLRP3, and IL-1β reduced in dose- and time-dependent manners. Furthermore, Asp upregulated the expression of NS3TP1 in vivo and in vitro, and NS3TP1 had a significant inhibitory effect on liver fibrosis. Asp attenuated liver fibrosis and reduced collagen production by suppressing the NF-κB/ NLRP3 signaling pathway via upregulating the expression of NS3TP1.
A data model for integrating BIM and blockchain to enable a single source of truth for the construction supply chain data delivery
Authors: Hijazi Amer A. , Perera Srinath , Calheiros Rodrigo N. , Alashwal Ali 
Published: June 2022

PurposeDespite a large amount of BIM data at the handover stage, it is still difficult to identify and effectively isolate valuable construction supply chain (CSC) data that need to be reliably handed over for operation. Moreover, the role of reconciling disparate data is usually played by one party. The integration of blockchain and BIM is a plausible framework for building a reliable digital asset lifecycle. This paper proposes a BIM single source of truth (BIMSSoT) data model using blockchain for ensuring a reliable CSC data delivery.Design/methodology/approachThis paper utilises a blended methodology, the foundation of which is ingrained in business and management research with elements of information and communication technology (ICT) research wherever required. Knowledge elicitation case studies utilising novel interventions such as a data flow diagram (DFD), taxonomy and entity-relationship diagram (ERD) were used in this paper to develop the BIMSSoT data model. The model was validated using an expert forum, and its technological feasibility was established by developing a proof of concept.FindingsThe practical contribution of this research leads to the progression of BIM towards digital engineering to go beyond object-based 3D modelling by building structured and reliable datasets, transitioning from project-centric records to a digital ecosystem of linked databases by utilizing blockchain's potential for ensuring trusted data.Originality/valueTo the best of the author's knowledge, prior to this paper, no research had investigated a detailed data model development leveraging blockchain and BIM to integrate an immutable and complete record of CSC data as another dimension of BIM for operations.
Stakeholders prioritization of key performance indicators on public and private tertiary educational projects in Osun State, Nigeria
Authors: Olatunde Nathaniel Ayinde , Fidelis Idienumah Monday , Awodele Imoleayo Abraham , Adebayo Bosede Olajumoke 
Published: June 2022

PurposeThe study assessed the stakeholders prioritization of key performance indicators (KPIs) on public and private tertiary educational projects in Osun State, Nigeria intending to enhance their performance.Design/methodology/approachThe study used a total enumeration survey to purposively select built environment professionals working in the Physical Planning and Development Unit (PPDU) and procurement units of 17 tertiary educational institutions (7public and 10 private) in Osun State Nigeria for data collection. A quantitative research approach was adopted for the study using a questionnaire. A total of 102 questionnaires were retrieved from the respondents and used for analysis. Analysis of data was done using frequency, percentile, mean score (MS), Cronbach's Alpha coefficient, t-test, and Analysis of variance (ANOVA).FindingsThe study found that in the overall opinion of the respondents the most prioritized KPIs for tertiary educational projects are for the project to meet specifications (MS = 4.17), the project must be on time (MS = 4.01), and efficient use of resources (MS = 3.96). The important KPIs for the public tertiary educational projects is that the project should meet specifications (MS = 4.08), deliver the projects on time (MS = 3.96), and be under cost (MS = 3.84). While, the most prioritized KPIs for private tertiary educational projects are for the project to meet specifications (MS = 4.25), efficient use of resources (MS = 4.14), on time, and doing the right thing (effectiveness) (MS = 4.06) each. More findings indicated that there is no significant difference in the manner built environment professionals prioritized KPIs. However, there is only a 7% significant difference in the manner professionals working in the public and private tertiary educational institutions in Nigeria ranked KPIs.Practical implicationsThere is a significant difference in the ways and manner built environment professionals working with the public and private tertiary educational institutions in Nigeria view resource utilization on their projects. As such, working environment either as public or private has a significant impact on resource utilization for tertiary educational construction projects.Originality/valueThe study compared opinions of professionals working with public and private tertiary educational institutions on KPIs to enhance project performance.
Socially responsible operations in the Industry 4.0 era: post-COVID-19 technology adoption and perspectives on future research
Authors: Asokan Deepak Ram , Huq Fahian Anisul , Smith Christopher M. , Stevenson Mark 
Published: June 2022

PurposeAs focal firms in supply networks reflect on their experiences of the pandemic and begin to rethink their operations and supply chains, there is a significant opportunity to leverage digital technological advances to enhance socially responsible operations performance (SROP). This paper develops a novel framework for exploring the adoption of Industry 4.0 technologies for improving SROP. It highlights current best-practice examples and presents future research pathways.Design/methodology/approachThis viewpoint paper argues how Industry 4.0 technology adoption can enable effective SROP in the post-COVID-19 era. Academic articles, relevant grey literature, and insights from industry experts are used to support the development of the framework.FindingsSeven technologies are identified that bring transformational capabilities to SROP, i.e. big data analytics, digital twins, augmented reality, blockchain, 3D printing, artificial intelligence, and the Internet of Things. It is demonstrated how these technologies can help to improve three sub-themes of organisational social performance (employment practices, health and safety, and business practices) and three sub-themes of community social performance (quality of life and social welfare, social governance, and economic welfare and growth).Research limitations/implicationsA research agenda is outlined at the intersection of Industry 4.0 and SROP through the six sub-themes of organisational and community social performance. Further, these are connected through three overarching research agendas: “Trust through Technology”, “Responsible Relationships” and “Freedom through Flexibility”.Practical implicationsOrganisational agendas for Industry 4.0 and social responsibility can be complementary. The framework provides insights into how Industry 4.0 technologies can help firms achieve long-term post-COVID-19 recovery, with an emphasis on SROP. This can offer firms competitive advantage in the “new normal” by helping them build back better.Social implicationsPeople and communities should be at the heart of decisions about rethinking operations and supply chains. This paper expresses a view on what it entails for organisations to be responsible for the supply chain-wide social wellbeing of employees and the wider community they operate in, and how they can use technology to embed social responsibility in their operations and supply chains.Originality/valueContributes to the limited understanding of how Industry 4.0 technologies can lead to socially responsible transformations. A novel framework integrating SROP and Industry 4.0 is presented.
Redesigning global supply chains during compounding geopolitical disruptions: the role of supply chain logics
Authors: Roscoe Samuel , Aktas Emel , Petersen Kenneth J. , Skipworth Heather Dawn , Handfield Robert B. , Habib Farooq 
Published: June 2022

PurposeWhy do managers redesign global supply chains in a particular manner when faced with compounding geopolitical disruptions? In answering this research question, this study identifies a constrained system of reasoning (decision-making logic) employed by managers when they redesign their supply chains in situations of heightened uncertainty.Design/methodology/approachThe authors conducted 40 elite interviews with senior supply chain executives in 28 companies across nine industries from November 2019 to June 2020, when the UK was preparing to leave the European Union, the US–China trade war was escalating, and Covid-19 was spreading rapidly around the globe.FindingsWhen redesigning global supply chains, the authors find that managerial decision-making logic is constrained by three distinct environmental ecosystem conditions: (1) the perceived intensity of institutional pressures; (2) the relative mobility of suppliers and supply chain assets; and (3) the perceived severity of the potential disruption risk. Intense government pressure and persistent geopolitical risk tend to impact firms in the same industry, resulting in similar approaches to decision-making regarding supply chain design. However, where suppliers are relatively immobile and supply chain assets are relatively fixed, a dominant logic is consistently present.Originality/valueBuilding on an institutional logics perspective, this study finds that managerial decision-making under heightened uncertainty is not solely guided by institutional pressures but also by perceptions of the severity of risk related to potential supply chain disruption and the immobility of supply chain assets. These findings support the theoretical development of a novel construct that the authors term ‘supply chain logics’. Finally, this study provides a decision-making framework for Senior Executives competing in an increasingly complex and unstable business environment.
Grace, place and space: fostering employee technological innovation in the new normal
Authors: Burleson James , Greenbaum Bruce E. , Thatcher Jason Bennett 
Published: June 2022

PurposeThe ongoing shift to telework has brought about tremendous opportunities for employees to reimagine their use of technology. Opportunities abound for both discovering new technologies and new uses of existing technologies. However, opportunity alone is not enough to turn ideas into action. This opinion paper aims to identify grace, place and space as key concepts that can help managers navigate challenges and opportunities for technological innovation posed by telework.Design/methodology/approachThe authors provide a concise review of related research and events that inform the selection of conditions necessary to foster employee technological innovation.FindingsThe authors identify three primary conditions necessary to foster employee technological innovation – grace, place and space. “Grace” refers to employee autonomy, “place” refers to networking and “space” refers to a reduction of overload. While telework may create opportunities for innovation, it also presents difficulties. Therefore, for each condition, the authors discuss inherent tensions and advise managers regarding how they can resolve those tensions and bring about innovation with a decentralized workforce.Originality/valueThe authors situate the discussion on facilitating conditions that foster employee technological innovation in today's current environment, one in which a rapid expansion of telework among employees is creating difficulties for managers. This paper addresses the “new normal” that managers will face for the foreseeable future.