bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Linkage between Achilles Tendon and Plantar Fascia Accounts for Range of Motion of Human Ankle–Foot Complex
Authors: SHIOTANI HIROTO , TAKAHASHI KATSUKI , HONMA YUKI , TOMARI KAZUKI , HAYASHI HIDETAKA , SADO NATSUKI , KAWAKAMI YASUO 
Published: August 2022

ABSTRACT

Purpose
The human ankle–foot complex possesses a passive range of motion (ROM) through changes in tibiocalcaneal (θ
cal) and foot arch (θ
arch) angles. Based on the anatomical linkage between the Achilles tendon (AT) and plantar fascia (PF), we hypothesized that AT and PF with different mechanical properties conjointly modulate the passive ROM of the human ankle–foot complex. We examined the association of AT and PF stiffness with passive ankle–foot ROM and further addressed differences between sexes.

Methods
A series of sagittal magnetic resonance images of the foot and passive ankle plantar flexion torque were obtained for 20 men and 20 women with their ankle–foot passively rotated from 30° of plantar flexion to 20° of dorsiflexion. Based on the measured changes in AT and PF lengths, θ
cal, θ
arch, and passive torque, AT and PF stiffness were determined.

Results
Upon passive ankle dorsiflexion, AT and PF were lengthened; their length changes were inversely correlated. Men showed a stiffer AT, more compliant PF, less calcaneal rotation, and greater foot arch deformation compared with women. Furthermore, we found inverse correlations between AT stiffness and ROM of θ
cal, and between PF stiffness and ROM of θ
arch in men and women.

Conclusions
Passive AT and PF extensibility counter each other. AT and PF stiffness and passive ROM of ankle–foot components were countered between sexes; however, associations between stiffness and passive ROM of the ankle–foot complex were consistent between sexes. Our findings support the notion that the balanced mechanical interaction between the AT and PF can account for the passive ROM of the human ankle–foot complex in vivo, and the differences between sexes.
Extended Match Time Exacerbates Fatigue and Impacts Physiological Responses in Male Soccer Players
Authors: MOHR MAGNI , ERMIDIS GEORGIOS , JAMURTAS ATHANASIOS Z. , VIGH-LARSEN Jeppe F. , POULIOS ATHANASIOS , DRAGANIDIS DIMITRIOS , PAPANIKOLAOU KONSTANTINOS , TSIMEAS PANAGIOTIS , BATSILAS DIMITRIOS , LOULES GEORGIOS , BATRAKOULIS ALEXIOS , SOVATZIDIS APOSTOLOS , NIELSEN JAKOB L. , TZATZAKIS THEOFANIS , DELI CHARIKLEIA K. , NYBO LARS , KRUSTRUP PETER , FATOUROS IOANNIS G. 
Published: August 2022

ABSTRACT

Purpose
This study evaluated how extended match time (90 + 30 min) affected physiological responses and fatigue in male soccer players.

Methods
Twenty competitive players (mean ± SD: age, 20 ± 1 yr; maximal oxygen uptake, 59 ± 4 mL·min−1·kg−1) completed an experimental match with their activity pattern and heart rate assessed throughout the game, whereas countermovement jump performance and repeated sprint ability were tested and quadriceps muscle biopsies and venous blood samples were taken at baseline and after 90 and 120 min of match play.

Results
Less high-intensity running (12%) was performed in extra time in association with fewer intense accelerations and decelerations per minute compared with normal time. Peak sprint speed was 11% lower in extra time compared with normal time, and fatigue also manifested in impaired postmatch repeated sprint ability and countermovement jump performance (all P < 0.05). Muscle glycogen declined from 373 ± 59 mmol·kg−1 dry weight (dw) at baseline to 266 ± 64 mmol·kg−1 dw after 90 min, with a further decline to 186 ± 56 mmol·kg−1 dw after extra time (P < 0.05) and with single-fiber analyses revealing depleted or very low glycogen levels in ~75% of both slow and fast twitch fibers. Blood glucose did not change during the first 90-min but declined (P < 0.05) to 81 ± 8 mg·dL−1 after extra time. Plasma glycerol and ammonia peaked at 236 ± 33 mg·dL−1 and 75 ± 21 μmol·L−1 after the extra period.

Conclusions
These findings demonstrate exacerbated fatigue after extra time compared with normal time, which seems to be associated with muscle glycogen depletion, reductions in blood glucose levels, and hyperammonemia. Together, this points to metabolic disturbances being a major part of the integrated and multifaceted fatigue response during extended soccer match play.
Reference Standards for Peak Rating of Perceived Exertion during Cardiopulmonary Exercise Testing: Data from FRIEND
Authors: PETERMAN JAMES E. , ARENA ROSS , MYERS JONATHAN , HARBER MATTHEW P. , BONIKOWSKE AMANDA R. , SQUIRES RAY W. , KAMINSKY LEONARD A. 
Published: August 2022

ABSTRACT

Introduction
Peak rating of perceived exertion (RPE) is measured during clinical cardiopulmonary exercise testing (CPX) and is commonly used as a subjective indicator of maximal effort. However, no study to date has reported reference standards or the distribution of peak RPE across a large cohort of apparently healthy individuals.

Purpose
This study aimed to determine reference standards for peak RPE when using the 6–20 Borg scale for both treadmill and cycle tests.

Methods
The analysis included 9551 tests (8821 treadmill, 730 cycle ergometer) from 13 laboratories within the Fitness Registry and Importance of Exercise National Database (FRIEND). Using data from tests conducted January 1, 1980, to January 1, 2021, percentiles of peak RPE for men and women were determined for each decade from 20 to 89 yr of age for treadmill and cycle exercise modes. Two-way ANOVA was used to compare differences in peak RPE values between sexes and across age groups.

Results
There were statistically significant differences in RPE between age groups whether the test was performed on a treadmill or cycle ergometer (P < 0.05). However, the mean and median RPE for each sex, age group, and test mode were between 18 and 19. In addition, 83% of participants met the traditional RPE criteria of ≥18 for indicating sufficient maximal effort.

Conclusions
This report provides the first normative reference standards for peak RPE in both male and female individuals performing CPX on a treadmill or cycle ergometer. Furthermore, these reference standards highlight the general consistency of peak RPE responses during CPX.
Effect of Pregnancy in 42 Elite to World-Class Runners on Training and Performance Outcomes
Authors: DARROCH FRANCINE , SCHNEEBERG AMY , BRODIE RYAN , FERRARO ZACHARY M. , WYKES DYLAN , HIRA SARITA , GILES AUDREY R. , ADAMO KRISTI B. , STELLINGWERFF TRENT 
Published: August 2022

ABSTRACT

Purpose
The International Olympic Committee expert group on pregnancy has identified a paucity of information regarding training and performance in truly elite athletes. Thus, the purpose of this study was to quantify elite runners’ training volume throughout pregnancy and postpartum competition performance outcomes.

Methods
Forty-two elite (>50% competed at the World Championships/Olympic) middle-/long-distance runners’ training before, during, and after pregnancy (quality/quantity/type) data (retrospective questionnaire) and competition data (published online) were collected.

Results
Running volume decreased significantly (P < 0.01) from the first trimester (63 ± 34 km·wk−1) to the third trimester (30 ± 30 km·wk−1). Participants returned to activity/exercise at ~6 wk postpartum and to 80% of prepregnancy training volumes by 3 months. Participants who intended to return to equivalent performance levels postpregnancy, there was no statistical decrease in performance in the 1 to 3 yr postpregnancy compared with prepregnancy, and ~56% improved performances postpregnancy.

Conclusions
This study features the largest cohort of elite runners training and competition outcomes assessed throughout pregnancy, with training volumes being approximately two to four times greater than current guidelines. For the first time, performance was directly assessed (due to the quantifiable nature of elite running), and study participants who intended to return to high-level competition did so at a statistically similar level of performance in the 1- to 3-yr period postpregnancy. Taken together, this article provides much needed insights into current training practices and performance of elite pregnant runners, which should help to inform future training guidelines as well as sport policy and sponsor expectations around return to training timelines and performance.
Curbing Emissions: Environmental Regulations and Product Offerings Across Markets
Authors: Han Zheng , Hu Bin , Dawande Milind 
Published: August 2022

Problem definition: In the U.S. auto market, the California Air Resources Board (CARB) implements a stricter fuel economy standard in California than the federal standard implemented by the U.S. Environmental Protection Agency (EPA). The Trump administration’s 2018 announcement to freeze the EPA standard threatened to widen its gap from the CARB standard and cause a split market where automakers offer differentiated car models in CARB and non-CARB states. Inspired by this crisis, we investigate three research questions: when is market unification (all vehicles meeting a common efficiency standard) attainable? Is unifying a split market likely to reduce total CO2emissions? If so, what strategies can help unify the market when unification does not occur naturally? Methodology/results: We adopt a game-theoretic model where two regulators with different levels of environmental awareness set efficiency standards in their respective markets, a firm offers product(s) for these markets, and consumers make purchases. We find that there exist cases where the firm offers a unified product for both markets, a different product in each market, or only serves one market, and our analysis suggests that unifying a split market may help curb emissions. We then propose and show that horizontal negotiations (between the regulators) and vertical negotiations (between a regulator and the firm) are potentially effective strategies to unify a split market and reduce emissions. Managerial implications: Our findings show that a more environmentally aware regulator can leverage its market power and reduce CO2emissions outside its jurisdiction through negotiations. Furthermore, our findings suggest that the regulator should prioritize horizontal negotiations while using vertical negotiations as a back-up option.Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2022.1141 .
Preparation and evaluation of LA-PEG-SPION, a targeted MRI contrast agent for liver cancer
Authors: Xia Lei , Song Xiaowei , Yan Guanghai , Quan Jishan , Jin Guangyu 
Published: August 2022

Abstract
This study aims to synthesize a magnetic resonance imaging (MRI) contrast agent that can specifically target the asialoglycoprotein receptor of liver cancer cells and evaluate its ability as a targeted MRI contrast agent. Lactobionic acid (LA) and polyethylene glycol (PEG) were used to modify superparamagnetic iron oxide nanoparticles (SPION) to obtain LA-PEG-SPION. LA-PEG-SPION was uniformly spherical under the electron microscope, with regular morphology and good dispersion. The particle size of LA-PEG-SPION was about 30 ± 4.5 nm, and its surface potential was about 31 ± 1.5 mV. LA-PEG-SPION had no toxicity or low toxicity to HepG2 cells and HeLa cells, even at 400 μg/mL. The uptake of LA-PEG-SPION by HepG2 cells was higher than that of SPION, with increased blue-stained particles. The fluorescent labeling rate of HepG2 cells reached 68.8%, which was higher than that of the control group. In vitro, MRI showed that the T2-weighted signal intensity of HepG2 cells was lower than that of the control group. Conclusively, LA-PEG-SPION nanoparticles are synthesized in a simple and efficient way. They are successfully applied to the T2-weighted contrast-enhanced MRI in liver cancer in vitro, and they have the potential to be used for in vivo research and clinical studies.
Bacteriospermia – A formidable player in male subfertility
Authors: Tvrdá Eva , Ďuračka Michal , Benko Filip , Lukáč Norbert 
Published: August 2022

AbstractBacterial colonization of male reproductive tissues, cells, and fluids, and the subsequent impact of bacteria on the sperm architecture, activity, and fertilizing potential, has recently gained increased attention from the medical and scientific community. Current evidence strongly emphasizes the fact that the presence of bacteria in semen may have dire consequences on the resulting male fertility. Nevertheless, the molecular basis underlying bacteriospermia-associated suboptimal semen quality is sophisticated, multifactorial, and still needs further understanding. Bacterial adhesion and subsequent sperm agglutination and immobilization represent the most direct pathway of sperm–bacterial interactions. Furthermore, the release of bacterial toxins and leukocytic infiltration, associated with a massive outburst of reactive oxygen species, have been repeatedly associated with sperm dysfunction in bacteria-infested semen. This review serves as a summary of the present knowledge on bacteriospermia-associated male subfertility. Furthermore, we strived to outline the currently available methods for assessing bacterial profiles in semen and to outline the most promising strategies for the prevention and/or management of bacteriospermia in practice.
Effects of weight gaining to lower limb joint moments: a gender-specific sit-to-stand analysis
Authors: Serbest Kasim 
Published: August 2022

Abstract
The prevalence of obesity, a worldwide health problem, is increasing. Obesity or overweight has significant effects, especially on lower limb biomechanics. Previous studies have investigated the biomechanical effects of weight gain on the knee and hip joints. These studies have been conducted on different individuals with normal weight and overweight. However, no investigation has been carried out between women and men in terms of weight gain. Females usually gain weight in the gluteal-femoral region, whereas males gain weight in the abdominal region. Due to this difference, it is thought that the effects of weight gain should be examined in a gender-specific manner. In this study, a link-segment model of the lower limb was created. Then the sit-to-stand movement was simulated according to female and male-specific weight gain scenarios. According to these results, weight gain in the abdominal region (men-specific) increases the ankle and knee joint moments more than weight gain in the gluteal-femoral region (women-specific). In obese scenarios for males and females, while the ankle and knee joint moment increases, the hip joint moment decreases. These results would be beneficial for considering biomechanical differences caused by gender-specific weight gain in rehabilitation processes and orthotic and prosthetic designs.
Biological variation estimates obtained from Chinese subjects for 32 biochemical measurands in serum
Authors: Ma Liming , Zhang Bin , Luo Limei , Shi Rui , Wu Yonghua , Liu Yunshuang 
Published: August 2022

Abstract

Objectives
The European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) have established a program of work to make available, and to enable delivery of well characterized data describing the biological variation (BV) of clinically important measurands. Guided by the EFLM work the study presented here delivers BV estimates obtained from Chinese subjects for 32 measurands in serum.

Methods
Samples were drawn from 48 healthy volunteers (26 males, 22 females; age range, 21–45 years) for 5 consecutive weeks at Chinese laboratory. Sera were stored at −80 °C before triplicate analysis of all samples on a Cobas 8000 modular analyzer series. Outlier and homogeneity analyses were performed, followed by CV-ANOVA, to determine BV estimates with confidence intervals.

Results
The within-subject biological variation (CVI) estimates for 30 of the 32 measurands studied, were lower than listed on the EFLM database; the exceptions were alanine aminotransferase (ALT), lipoprotein (a) (LP(a)). Most of the between-subject biological variation (CVG) estimates were lower than the EFLM database entries.

Conclusions
This study delivers BV data for a Chinese population to supplement the EFLM BV database. Population differences may have an impact on applications of BV Data.
Slavic Studies in China
Authors: Dai Guiju , Zhao Gang 
Published: August 2022

Abstract
Slavic studies in China have long been conducted under the category of the Soviet Union and Eastern European studies. In the past three decades, the research in China has turned to the attention of various Slavic countries amid the evolving domestic and international situations. With a number of research findings in Slavic language, literature, and area studies, Slavic studies in China have contributed its share to the development of philosophy, social science, and the building of our country as a whole. As an emerging discipline, our research is expected to include studies of every Slavic country, do more comparative research among Slavic nations, optimize the discipline system, and amplify its voice worldwide. We believe that with the joint effort of Chinese researchers our Slavic studies will earn a place in the field of international Slavic research.
Research on the structure of smart medical industry based on the background of the internet of things
Authors: Zhang Luhong , Zhou Kai , Zhao Weibin , Zhou Huiyan 
Published: August 2022

Abstract
In view of the current development trend of the smart medical industry in the context of the internet of things, this study conducts an evolutionary game analysis on information technology providers, medical institutions, digital medical equipment providers, and medical regulatory agencies in the smart medical industry. This study also analyzes the stable state of the future development of the smart medical industry and performs simulation calculations through MATLAB software. The research results show that the overall development trend of the smart medical industry structure in the future is consistent with the development trend of each industry structure. Under the strategic background of the supervision of medical regulatory agencies, information technology providers and digital medical equipment providers, respectively, provide the smart medical industry with the latest information technology and digital medical equipment to ensure the technical support of the smart medical industry. The smart medical industry provides corresponding medical talents and medical equipment to ensure the demand for talents and equipment of the smart medical industry, so that the structure of the smart medical industry can continuously improve the level of smart medical technology in the future development and ultimately promote the overall development of the smart medical industry.
The road chronotope in rural colonial Philippines
Authors: Reyes Maria Luisa Torres 
Published: August 2022

Abstract
Through a chronotopic reading of “How My Brother Leon Brought home a Wife” by Manuel E Arguilla, a famous short story in English included in textbooks and anthologies of Philippine literature published during the American colonial era, the role of the contextual “background” features of fiction are brought into the textual foreground in order to focus on their dynamic relations. This attention to the mutual constitution of the text and context which are conventionally understood to be exclusive if not exclusionary of each other is meant to show how, in fact, the spatio-temporal structuring and generic framing of the text highlight the role of the “aesthetic” (the “intrinsic” textual elements of artistic form) while also foregrounding the very “politics” of the story’s context (the “extrinsic” contextual reality of society out there). Indeed, as the paper argues through a broadly narratological close reading of “How My Brother Leon Brought Home a Wife,” the story’s chronotope shows how text and context are mutually constitutive and inextricable spatio-temporal dimensions of the story embodying the story’s textual framing and structuring, marking its narratological significance, both aesthetically and politically against the larger backdrop of resistance movements during the American colonial period.
Conceptions of literary authorship in modern literary theories: history, issues, approaches
Authors: Lang Mengchen 
Published: August 2022

AbstractThe last three decades have seen a flourishing of theoretical discussions about the concept of literary authorship. This article is an attempt to scrutinise and engage with this thriving scene. Through a systematic review of conceptions of authorship in modern literary theories, I will outline historical shifts, disentangle current debates, and identify a range of approaches, with the aim of informing future studies of this concept. This article is divided into three parts. The first part offers a brief history of ideas of authorship in modern literary theories (ca. 1900 to the present). I trouble the narrative of the ‘death and resurrection of the author’ by showing that the concept of authorship has remained a constant concern, and by highlighting continuities between different theories. The second part identifies three main issues about the concept – agency/creativity, intention/authority, and self-presentation/self-construction. I illustrate how each of them has been addressed in recent discussions, focusing mainly on the last three decades, and point to potential directions for future research within each strand of debate. Finally, I provide a non-exhaustive typology of methodological approaches to the study of authorship. I will conclude with a brief consideration of the value of this concept for literary criticism.
Balance history and fiction in narrative: Approaching Walter Scott’s classical historical novels
Authors: Chen Qi 
Published: August 2022

Abstract
Water Scott sets up the literary genre with his outstanding and genuine composition of twenty-seven historical novels. With unique and tactical narrative strategies, Scott successfully balances the real historical world and the fictional world in the stories. Scrutinizing from four aspects, namely plotting, narrative time, narrator and focalization, and characterization, the present paper will reveal how the history is told in a fictional world without losing the historicity and keeping the vividness at the same time. Taking the faithfulness to history as the major principle, Scott fabricates a fascinating fictional world embedded with his understanding and emotions of the past.
Buoyancy driven flow characteristics inside a cavity equiped with diamond elliptic array
Authors: Chaabane Raoudha , Kolsi Lioua , Jemni Abdelmajid , D’Orazio Annunziata 
Published: August 2022

AbstractThis study numerically investigates the two-dimensional natural convection in a square enclosure with an isothermal diamond elliptic array at Rayleigh numbers of 104≤ Ra ≤ 107. Three cases are considered, i.e., case 1 where two pairs of circular heating bodies are used inside the cavity, one is placed on the vertical centerline (VC) of the cavity and the other on the horizontal centerline (HC), case 2 where one pair of horizontal elliptic heating bodies is placed on the VC of the cavity and the other on the HC and case 3 where the horizontal elliptic heating bodies are replaced by vertical elliptic heating bodies. Numerical simulation was carried out based on the mesoscopic approach (LBM). The effects of the horizontally and vertically heated arrays were investigated. We demonstrate that, only when the Rayleigh number increases to Ra = 107, the numerical solutions reach an unsteady state for all cases. The transition of the flow regime from the unsteady state to the steady state depends on the variation in the ratio of the elliptical cylinder.