bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of pair migratory behavior on breeding phenology and success in a partially migratory shorebird population
Authors: Méndez Verónica , Alves Jose A. , Gill Jennifer A. , Þórisson Böðvar , Carneiro Camilio , Pálsdóttir Aldís E. , Vignisson Sölvi R. , Gunnarsson Tomas G. 
Published: August 2022

AbstractIn migratory systems, variation in individual phenology can arise through differences in individual migratory behaviors, and this may be particularly apparent in partial migrant systems, where migrant and resident individuals are present within the same population. Links between breeding phenology and migratory behavior or success are generally investigated at the individual level. However, for breeding phenology in particular, the migratory behaviors of each member of the pair may need to be considered simultaneously, as breeding phenology will likely be constrained by timing of the pair member that arrives last, and carryover effects on breeding success may vary depending on whether pair members share the same migratory behavior or not. We used tracking of marked individuals and monitoring of breeding success from a partially migrant population of Eurasian oystercatchers (Haematopus ostralegus) breeding in Iceland to test whether (a) breeding phenology varied with pair migratory behavior; (b) within‐pair consistency in timing of laying differed among pair migratory behaviors; and (c) reproductive performance varied with pair migratory behavior, timing of laying, and year. We found that annual variation in timing of laying differed among pair migratory behaviors, with resident pairs being more consistent than migrant and mixed pairs, and migrant/mixed pairs breeding earlier than residents in most years but later in one (unusually cold) year. Pairs that laid early were more likely to replace their clutch after nest loss, had higher productivity and higher fledging success, independent of pair migratory behavior. Our study suggests that the links between individual migratory behavior and reproductive success can vary over time and, to a much lesser extent, with mate migratory behavior and can be mediated by differences in laying dates. Understanding these cascading effects of pair phenology on breeding success is likely to be key to predicting the impact of changing environmental conditions on migratory species.
Sensitive Electrochemical Detection of Thiabendazole in Fruits Using Ag−MoS2 Electrode
Authors: Mola Aster Manyazewal , Debebe Siraye Esubalew , Mekonnen Menbere Leul 
Published: August 2022

AbstractHerein, Ag nanoparticles (NPs) modified MoS2 (Ag−MoS2) was applied to the surface of glassy carbon (GC) to produce a robust electrochemical sensor for the detection of thiabendazole, a common antifungal in the post‐harvesting of fruits. Cyclic voltammetry studies confirmed thiabendazole exhibited an irreversible, diffusion‐controlled process on Ag−MoS2 with a two‐fold increase in peak current than the pristine MoS2. A square wave voltammetry was used for the detection of TBZ. The developed sensor exhibited a linear range between 1–10 μM with LOD down to 0.1 μM (S/N>3). Analysis of TBZ in mango and banana matrices gave a recovery of 91.6–100.4 % indicating the suitability of the sensor for food safety monitoring.
Subjective disgust and facial electromyography responses towards unedited and morphed overweight self‐pictures in women with varying levels of eating disorder symptomatology
Authors: Masselman Irina , de Jong Peter J. , Glashouwer Klaske A. 
Published: August 2022

AbstractIndividuals with an eating disorder (ED) often report to be disgusted by their body. Body‐related self‐disgust could play an important role in the development and maintenance of EDs. We investigated if women with relatively high ED symptom scores indeed respond with disgust upon exposure to their body as indexed by facial electromyography (fEMG) of the m. levator labii superioris and self‐report. Given that one's self‐disgust may increase/decrease depending on the relative distance of the own body to the thin ideal, we also assessed women's disgust for overweight‐ and thin‐morphs of their body. Female undergraduate students (N = 104) were photographed and presented with their (morphed) body pictures, next to disgust‐relevant and overweight body control pictures. Higher levels of ED symptoms were associated with stronger self‐reported disgust to unedited body‐pictures and overweight‐morphs. Disgust to thin‐morphs was unrelated to ED symptoms. Participants generally showed heightened facial disgust towards overweight morphs, yet the strength of facial disgust was unrelated to ED symptoms. Thus, the findings provide evidence for the involvement of heightened body‐related self‐disgust in ED symptomatology, albeit only on the basis of self‐report.
Thermal performance assessment of phase change material for electronic cooling: An experimental investigation
Authors: Pandiyan Prashanth Soundra , Dandotiya Devendra , Alathadi Maloor Surendrakumar , Rajagopalan Sudheer 
Published: August 2022

AbstractIn the present study, an experimental investigation is performed to check the performance of phase change material (PCM) OM42 for passive electronic cooling applications. Rectangular fins were used as PCM thermal conductivity enhancers (TCEs) to enhance the thermal conductivity of PCM. The experiments were performed (a) by maintaining the required input heat flux to the heater and (b) by maintaining the set point temperature (SPT) of the heater. The heater wattage controller was used to supply the required power to the heater and thermostat W1209 was used to control the SPT of the heater. The experiments were performed in the combination of PCM and fins, with fins only, With PCM only, and with PCM and fins. The obtained results signify improved performance of the heat sink when PCM with fins was used. At input heat flux of 1, 2, 3, 4 and 5 kW/m2 the heat sink reaches the critical temperature in 80, 60, 55, 50 and 40 minutes respectively in the absence of PCM without fins, but with the presence of PCM without fins and PCM with fins, the heater sink is well below the critical temperature for a complete charging cycle. At input heat flux of 4 and 5 kW/m2, the intensity of PCM melting rate is faster and hence solid‐liquid interface decreases quite rapidly as the buoyancy force dominates the viscous force since the volume of liquid PCM rises as the natural convection effect increases in the liquid region.
Tanshinone IIA improves diabetes‐induced renal fibrosis by regulating the miR‐34‐5p/Notch1 axis
Authors: Zhang Lizhi , Yang Fan 
Published: August 2022

AbstractThe purpose of this study was to evaluate the improvement of tanshinone in renal fibrosis in vitro and in vivo study. It used streptozotocin to model diabetic nephropathy (DN) mice, and treated with different Tanshinone IIA concentrations. The pathology of kidney tissues was evaluated by hematoxylin and eosin (H&E) and Masson's staining; the ultrastructure and apoptosis cell number of kidney tissues were evaluated by transmission electron microscopy (TEM) and TUNEL assay. Relative gene and protein expression was evaluated by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR), immunohistochemical (IHC) analysis, or western blot (WB) assay. In vitro study, using high‐glucose stimulated HK‐2 cell to model DN cell model, measuring cell proliferation, apoptosis rate, relative gene and protein expression, and LC 3B and P62 proteins expression by Cell Counting Kit‐8 (CCK‐8), flow cytometry, RT‐qPCR, WB, and cell immunofluorescence. Analysis correlation between Notch1 and miRNA‐34a‐5p was carried out by dual‐luciferase reporter. Fibrosis area and apoptosis cell rate were significantly up‐regulated (p < .001), with Tanshinone IIA supplement. The fibrosis area and apoptosis cell rate were also significantly improved in a dose‐dependent manner (p < .05). With si‐miRNA‐34a‐5p transfection, the Tanshinone IIA's treatment effects were significantly depressed. By dual‐luciferase reporter, miRNA‐34a‐5p could target Notch1 in the HK‐2 cell line. Tanshinone IIA improved DN‐induced renal fibrosis by regulating miRNA‐34a‐5p in vitro and in vivo study.
Prozesse der Versinterung – Kenntnisstand und aktuelle Herausforderungen
Authors: Dietzel Martin , Eichinger Stefanie 
Published: August 2022

AbstractScale formation in water drainage systems occurs in diverse forms. In tunnel drainage systems in particular, calcium carbonate deposition can significantly impair water discharge, resulting in costly maintenance work and tunnel closures. This review paper presents and discusses the state of knowledge as well as the current challenges regarding scale formation in tunnel drainage systems in terms of typification, parameters controlling formation, such as hydrochemistry, interfacial phenomena, microbial activity, and countermeasures, such as appropriate adaptation of construction materials, drainage design, inhibitor use and cleaning. Detailed knowledge of the case‐specific scale formation environment and the scaling capacities of the waters provides the basis for the tailored development and evaluation of suitable strategies for successfully reducing maintenance efforts and tunnel closure. For this purpose, time‐ and site‐resolved monitoring of the composition of the solid phases, waters and the tunnel atmosphere during the implementation of the construction project and during the operation of the tunnel is paramount.
Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits
Authors: Fryett James J. , Morris Andrew P. , Cordell Heather J. 
Published: August 2022

AbstractAs popularised by PrediXcan (and related methods), transcriptome‐wide association studies (TWAS), in which gene expression is imputed from single‐nucleotide polymorphism (SNP) genotypes and tested for association with a phenotype, are a popular approach for investigating the role of gene expression in complex traits. Like gene expression, DNA methylation is an important biological process and, being under genetic regulation, may be imputable from SNP genotypes. Here, we investigate prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits. We start by examining how well CpG methylation can be predicted from SNP genotypes, comparing three penalised regression approaches and examining whether changing the window size improves prediction accuracy. Although methylation at most CpG sites cannot be accurately predicted from SNP genotypes, for a subset it can be predicted well. We next apply our methylation prediction models (trained using the optimal method and window size) to carry out a methylome‐wide association study (MWAS) of primary biliary cholangitis. We intersect the regions identified via MWAS with those identified via TWAS, providing insight into the interplay between CpG methylation, gene expression and disease status. We conclude that MWAS has the potential to improve understanding of biological mechanisms in complex traits.
How adenomyosis changes throughout pregnancy: A retrospective cohort study
Authors: Bertucci Emma , Sileo Filomena G. , Diamanti Marialaura , Alboni Carlo , Facchinetti Fabio , La Marca Antonio 
Published: August 2022

AbstractObjectiveTo study how adenomyosis changes during pregnancy and to possibly correlate these changes to maternal and fetal outcomes.MethodsRetrospective exploratory cohort study including 254 women with a pre‐conceptional/first‐trimester scan to document adenomyosis and known obstetric outcome. If visible, adenomyosis signs were documented in each trimester and postpartum. Mann–Whitney U tests or χ2 tests were used for continuous and categorical variables, respectively.ResultsA globular uterus was reported in 79% (n = 52) of women with adenomyosis in the first trimester, in 38% (n = 20) and 2% (n = 1) of women in the second and third trimesters, respectively, and postpartum in 77% (n = 34) of women. Asymmetrical thickening (n = 20, 30%) and cysts (n = 15, 23%) were only visible in 1st trimester. Adenomyosis was associated with miscarriage (odds ratio [OR] 5.9, 95% confidence interval [CI] 2.4–14.9, P < 0.001) also in normal conception only (OR 5.1, 95% CI 1.8–14.2, P = 0.002) or adjusting for maternal age (adjusted OR 5.9, 95% CI 2.3–15.2, P < 0.001). Gestational age at delivery was lower in adenomyosis (P = 0.004); the cesarean section rate was higher than in controls (OR 2.5, 95% CI 1.3–4.8, P = 0.007) also adjusting for age (adjusted OR 2.07, 95% CI 1.06–4.08, P = 0.035).ConclusionsSigns of adenomyosis were visible but progressively disappeared in pregnancy; adenomyosis was associated with an increased risk of early miscarriage. Prospective studies are needed to confirm our results.
European Enhanced Recovery After Surgery (ERAS) gynecologic oncology survey: Status of ERAS protocol implementation across Europe
Authors: Gómez‐Hidalgo Natalia R. , Pletnev Andrei , Razumova Zoia , Bizzarri Nicolò , Selcuk Ilker , Theofanakis Charalampos , Zalewski Kamil , Nikolova Tanja , Lanner Maximilian , Kacperczyk‐Bartnik Joanna , El Hajj Houssein , Perez‐Benavente Assumpció , Nelson Gregg , Gil‐Moreno Antonio , Fotopoulou Christina , Sanchez‐Iglesias Jose Luis 
Published: August 2022

AbstractObjectiveTo acquire a comprehensive assessment of the current status of implementation of Enhanced Recovery After Surgery (ERAS) protocols across Europe.MethodsThe survey was launched by The European Network of Young Gynecologic Oncologists (ENYGO). A 45‐item survey was disseminated online through the European Society of Gynecological Oncology (ESGO) Network database.ResultsA total of 116 ESGO centers participated in the survey between December 2020 and June 2021. Overall, 80 (70%) centers reported that ERAS was implemented at their institution: 63% reported a length of stay (LOS) for advanced ovarian cancer surgery between 5 and 7 days; 57 (81%) centers reported a LOS between 2 and 4 days in patients who underwent an early‐stage gynecologic cancer surgery. The ERAS items with high reported compliance (>75% “normally‐always”) included deep vein thrombosis prophylaxis (89%), antibiotic prophylaxis (79%), prevention of hypothermia (55%), and early mobilization (55%). The ERAS items that were poorly adhered to (less than 50%) included early removal of urinary catheter (33%), and avoidance of drains (25%).ConclusionThis survey shows broad implementation of ERAS protocols across Europe; however, a wide variation in adherence to the various ERAS protocol items was reported.
Successful radiofrequency ablation of liver metastases from prostate cancer
Authors: Hino Daichi , Sugano Takahiro , Kino Mika , Nakata Takako , Kito Hiroki , Inoue Masafumi , Fujie Hajime , Akakura Koichiro 
Published: August 2022

IntroductionPatients with liver metastases from prostate cancer show poor prognosis. We performed metastases‐directed therapy using radiofrequency ablation of liver metastases in an attempt to improve the prognosis in a patient with metastatic prostate cancer.Case presentationWe present the case of a 66‐year‐old man who was treated for metastatic castration‐resistant prostate cancer. Evaluation showed isolated liver metastases together with elevated serum prostate‐specific antigen levels. We performed metastases‐directed therapy using radiofrequency ablation of the liver tumor. The patient showed no recurrent liver metastases for 42 months and survived for 66 months after diagnosis of metastatic prostate cancer.ConclusionTo our knowledge, this is the first report that describes radiofrequency ablation of liver metastases from prostate cancer. This procedure may be a useful therapeutic option for metastases‐directed therapy in patients with liver metastases from prostate cancer.
Synthetic oleanane triterpenoid derivative CDDO‐Me disrupts cellular bioenergetics to suppress pancreatic ductal adenocarcinoma via targeting SLC1A5
Authors: Akuetteh Percy D. P. , Huang Huimin , Wu Shijia , Zhou Hongfei , Jin Guihua , Hong Welong , Yang Hongbao , Lan Linhua , Shangguan Fugen , Zhang Qiyu 
Published: August 2022

AbstractTo investigate the potential antitumor activity of synthetic triterpenoid, methyl‐2‐cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oate (CDDO‐Me) in pancreatic ductal adenocarcinoma (PDAC), MTT cytotoxicity assay, and xenograft nude mice assay were performed to evaluate tumor growth in vitro and in vivo. Seahorse XFe96 bioenergetics analyzer was applied to determine aerobic glycolysis and mitochondrial respiration. Western blot and quantitative reverse transcription‐polymerase chain reactions are used to detect protein and messenger RNA transcripts of SLC1A5 and metabolic enzymes. We confirmed the strong antitumor activity of CDDO‐Me in suppressing PDAC growth. Mechanistically, we demonstrated CDDO‐Me induced mitochondrial respiration and aerobic glycolysis dysfunction. We also verified CDDO‐Me downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species (ROS) levels that suppressed tumor growth. Moreover, we confirmed that SLC1A5 depletion reduced the ratio of glutathione/oxidized glutathione. We also found CDDO‐Me could inhibit N‐linked glycosylation of SLC1A5, which promotes protease‐mediated degradation. Finally, we confirmed SLC1A5 was significantly overexpressed in PDAC and closely correlated with the poor prognosis of PDAC patients. Our work uncovers CDDO‐Me is effective at suppressing PDAC cell growth in vitro and in vivo and illuminates CDDO‐Me caused excessive ROS and cellular bioenergetics disruption which contributed to CDDO‐Me inhibited PDAC growth. Our data highlights CDDO‐Me could be considered a potential compound for PDAC therapy, and SLC1A5 could be a novel biomarker for PDAC patients.
High COL10A1 expression potentially contributes to poor outcomes in gastric cancer with the help of LEF1 and Wnt2
Authors: Zhang Miaozun , Jin Ming , Gao Zhiqiang , Yu Weiming , Zhang Wei 
Published: August 2022

AbstractBackgroundCOL10A1 is a secreted, short‐chain collagen found in several types of cancer. Studies have shown that COL10A1 aberrant expression is considered an oncogenic factor. However, its underlying mechanisms and regulation of gastric cancer remain undefined.MethodsThe data on the expression of COL10A1, clinicopathological characteristics, and outcome of patients with GC were obtained from The Cancer Genome Atlas. The ALGGEN‐PROMO database defined the related transcription factors. Quantitative real‐time reverse transcription‐polymerase chain reaction and western blotting analysis were used to identify the differential expression levels of COL10A1 and related transcription factors.ResultsWe found that high COL10A1 expression is an independent risk factor for gastric cancer. Upregulation of LEF1 and Wnt2 was also observed in gastric cancer, suggesting a potential correlation between LEF1/COL10A1 regulation in the Wnt2 signaling pathway.ConclusionHigh COL10A1 expression may contribute to poor outcomes via upregulation of LEF1 and Wnt2 in gastric cancer.
Characterizing circular colouring mixing for pq<4 $\frac{p}{q}\lt 4$
Authors: Brewster Richard C. , Moore Benjamin 
Published: August 2022

AbstractGiven a graph , the ‐mixing problem asks: Starting with a ‐colouring of , can one obtain all ‐colourings of by changing the colour of only one vertex at a time, while at each step maintaining a ‐colouring? More generally, for a graph , the ‐mixing problem asks: Can one obtain all homomorphisms , starting from one homomorphism , by changing the image of only one vertex at a time, while at each step maintaining a homomorphism ? This paper focuses on a generalization of ‐colourings, namely, ‐circular colourings. We show that when , a graph is ‐mixing if and only if for any ‐colouring of , and any cycle of , the wind of the cycle under the colouring equals a particular value (which intuitively corresponds to having no wind). As a consequence we show that ‐mixing is closed under a restricted homomorphism called a fold. Using this, we deduce that ‐mixing is co‐NP‐complete for all , and by similar ideas we show that if the circular chromatic number of a connected graph is , then folds to . We use the characterization to settle a conjecture of Brewster and Noel, specifically that the circular mixing number of bipartite graphs is 2. Lastly, we give a polynomial time algorithm for ‐mixing in planar graphs when .
Susceptibility to mice and potential evolutionary characteristics of porcine deltacoronavirus
Authors: Zhang Honglei , Ding Qingwen , Yuan Jin , Han Fangfang , Wei Zhanyong , Hu Hui 
Published: August 2022

AbstractPorcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in suckling piglets and has the potential for cross‐species transmission, posing a threat to animal and human health. However, the susceptibility profile of different species of mice to PDCoV infection and its evolutionary characteristics are still unclear. In the current study, we found that BALB/c and Kunming mice are susceptible to PDCoV. Our results showed that there were obvious lesions in intestinal and lung tissues from the infected mice. PDCoV RNAs were detected in the lung, kidney, and intestinal tissues from the infected mice of both strains, and there existed wider tissue tropism in the PDCoV‐infected BALB/c mice. The RNA and protein levels of aminopeptidase N from mice were relatively high in the kidney and intestinal tissues and obviously increased after PDCoV infection. The viral‐specific IgG and neutralizing antibodies against PDCoV were detected in the serum of infected mice. An interesting finding was that two key amino acid mutations, D138H and Q641K, in the S protein were identified in the PDCoV‐infected mice. The essential roles of these two mutations for PDCoV‐adaptive evolution were confirmed by cryo‐electron microscope structure model analysis. The evolutionary characteristics of PDCoV among Deltacoronaviruses (δ‐CoVs) were further analyzed. δ‐CoVs from multiple mammals are closely related based on the phylogenetic analysis. The codon usage analysis demonstrated that similar codon usage patterns were used by most of the mammalian δ‐CoVs at the global codon, synonymous codon, and amino acid usage levels. These results may provide more insights into the evolution, host ranges, and cross‐species potential of PDCoV.