bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of upper limb movement disorders using wearable sensors during functional tasks: a systematic review
Authors: Vanmechelen Inti , Haberfehlner Helga , De Vleeschhauwer Joni , Van Wonterghem Ellen , Feys Hilde , Desloovere Kaat , Aerts Jean-Marie , Monbaliu Elegast 
Published: October 2022

AbstractBackgroundStudies aiming to objectively quantify upper limb movement disorders during functional tasks using wearable sensors have recently increased, but there is a wide variety in described measurement and analyzing methods, hampering standardization of methods in research and clinics. Therefore, the primary objective of this review was to provide an overview of sensor set-up and type, included tasks, sensor features and methods used to quantify movement disorders during upper limb tasks in multiple pathological populations. The secondary objective was to select the most sensitive sensor features for symptom detection and quantification and discuss application of the proposed methods in clinical practice.MethodsA literature search using Scopus, Web of Science, and PubMed was performed. Articles needed to meet following criteria: (1) participants were adults/children with a neurological disease, (2) (at least) one sensor was placed on the upper limb for evaluation of movement disorders during functional tasks, (3) comparisons between: groups with/without movement disorders, sensor features before/after intervention, or sensor features with a clinical scale for assessment of the movement disorder. (4) Outcome measures included sensor features from acceleration/angular velocity signals.ResultsA total of 101 articles were included, of which 56 researched Parkinson’s Disease. Wrist(s), hand and index finger were the most popular sensor locations. The most frequent tasks for assessment were: finger tapping, wrist pro/supination, keeping the arms extended in front of the body and finger-to-nose. The most frequently calculated sensor features were mean, standard deviation, root-mean-square, ranges, skewness, kurtosis and entropy of acceleration and/or angular velocity, in combination with dominant frequencies and power of acceleration signals. Examples of clinical applications were automatization of a clinical scale or discrimination between a patient/control group or different patient groups.ConclusionCurrent overview can support clinicians and researchers to select the most sensitive pathology-dependent sensor features and measurement methodologies for detection and quantification of upper limb movement disorders and for the objective evaluations of treatment effects. The insights from Parkinson’s Disease studies can accelerate the development of wearable sensors protocols in the remaining pathologies, provided that there is sufficient attention for the standardisation of protocols, tasks, feasibility and data analysis methods.
Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility
Authors: Liao SY , Jacobson S , Hamzeh NY , Culver DA , Barkes BQ , Mroz P , Macphail K , Pacheco K , Patel DC , Wasfi YS , Koth LL , Langefeld CD , Leach S , White E , Montgomery C , Maier LA , Fingerlin TE ,   GRADs investigators
Published: October 2022

AbstractSarcoidosis is a complex systemic disease. Our study aimed to 1) identify novel alleles associated with sarcoidosis susceptibility; 2) provide an in-depth evaluation of HLA alleles and sarcoidosis susceptibility; 3) integrate genetic and transcription data to identify risk loci that may more directly impact disease pathogenesis.We report a genome-wide association study of 1,335 sarcoidosis cases and 1,264 controls of European descent (EA) and investigate associated alleles in a study of African Americans (AA: 1,487 cases and 1,504 controls). The EA cohort was recruited from National Jewish Health, Cleveland Clinic, University of California San Francisco, and Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis. The AA cohort was from a previous study with subjects enrolled from multiple United States sites. HLA alleles were imputed and tested for association with sarcoidosis susceptibility. Expression quantitative locus and colocalization analysis were performed using a subset of subjects with transcriptome data.49 SNPs inHLA-DRA, -DRB9, -DRB5, -DQA1, andBRD2genes were significantly associated with sarcoidosis susceptibility in EA. Among them, rs3129888 was also a risk variant for sarcoidosis in AA. Classical HLA alleles DRB1*0101, DQA1*0101, and DQB1*0501, which are highly correlated, were also associated with sarcoidosis. rs3135287 nearHLA-DRAwas associated withHLA-DRAexpression in peripheral blood mononuclear cells and bronchoalveolar lavage.In summary, we identified several novel SNPs and three HLA alleles associated with sarcoidosis susceptibility in the largest EA population evaluated to date using an integrative analysis of genetics and transcriptomics. We also replicated our findings in an AA population.
Isolation and crystal and molecular structures of [(C5H2Br3)2Fe], [(C5HBr4)2Fe] and [(C5Br5)(C5Br4HgBr)Fe]
Authors: Blockhaus Tobias , Sünkel Karlheinz 
Published: October 2022

The reaction of [(C5H3Br2)2Fe] with lithium tetramethylpiperidinide (LiTMP) in a 1:10 molar ratio in tetrahydrofuran yields, after quenching with C2H2Br4, a mixture of the polybromoferrocenes [C10H10–n
Br
n
Fe] with n = 4–9, from which single crystals of bis(1,2,3-tribromocyclopentadienyl)iron(II), [Fe(C5H2Br3)2], and bis(1,2,3,4-tetrabromocyclopentadienyl)iron(II), [Fe(C5HBr4)2Fe], were obtained by a combination of chromatography and fractional crystallization. Treatment of `[C10(HgOAc)10Fe]' with KBr3 yields a mixture of polybromoferrocenes [C10H10–n
Br
n
Fe] with n = 8–10 and bromomercurioferrocenes [C10H9–n
Br
n
(HgBr)Fe] with n = 7–9, from which single crystals of (1-bromomercurio-2,3,4,5-tetrabromocyclopentadienyl)(1,2,3,4,5-pentabromocyclopentadienyl)iron(II), [FeHgBr(C5Br4)(C5Br5)], were obtained by fractional crystallization. The crystal structures of all the compounds show Br...Br, Br...H and sometimes Br...Cp...π (Cp is a ring centroid) interactions, as well as π–π interactions. The findings are supported by Hirshfeld analyses.
ESG dimensions and bank performance: an empirical investigation in Italy
Authors: Menicucci Elisa , Paolucci Guido 
Published: October 2022

Purpose
This study aims to investigate the impact of environmental performance, social responsibility and corporate governance (ESG) on bank performance (BP) in the Italian banking sector. It analyzes the relationships between 10 dimensions of ESG pillars and BP indicators during the period 2016–2020.

Design/methodology/approach
This study examines a sample of 105 Italian banks and develops three econometric models to verify the effect of ESG initiatives on BP indicators. The independent variables are the ESG dimensions collected from the Refinitiv database, whereas the explanatory variables are performance indicators measured through accounting and market variables.

Findings
The findings show that ESG policies negatively affect operational and market performance in the banking sector, suggesting that Italian banks have not fully embraced strong sustainability procedures. However, the relationships between ESG dimensions are mixed if measured individually. The results show a significant positive impact of emission and waste reductions on financial and operating performance, but regarding social aspects, it is proved that better product responsibility decreases accounting performance.

Research limitations/implications
This study offers an in-depth examination of ESG practices in relation to current and future performance. In particular, the findings provide practitioners and academics with an actual set of predictors in the ESG area to improve BP.

Originality/value
To the best of the authors’ knowledge, this is the only study that has investigated the impact of ESG issues on BP in Italy. Few prior studies have used all dimensions of ESG policies at a disaggregated level to investigate their effect on various performance indicators.
Fostering customer loyalty across countries in hospitality and tourism: a meta-analysis of cultural values as moderators
Authors: Qi Xiaoxiao , Shi Da , Huang Zixuan , Chang Wen 
Published: October 2022

Purpose
This study aims to meta-analyze the moderating roles of Hofstede’s four cultural values in the antecedent–tourist loyalty link.

Design/methodology/approach
Based on 35 independent studies, a meta-regression was conducted to determine whether the heterogeneity of 11 antecedent–tourist loyalty relationships could be explained by four dimensions of Hofstede’s cultural values. Furthermore, this study tested how these relationships were contingent on each cultural value dimension, reinforced by robustness tests involving subgroup analyses.

Findings
The intensity of all associations significantly varied by at least one cultural value dimension, namely, power distance, individualism, masculinity or uncertainty avoidance.

Research limitations/implications
This meta-analytic study enriches the relevant literature by referring to a large, diverse sample to enhance the robustness of the moderating role of tourists’ national culture in loyalty formation and revealing the moderating effect of national culture in 11 antecedent–tourist loyalty links more than in extant literature.

Originality/value
For the body of knowledge of culture-moderated tourist loyalty formation, to the best of the authors’ knowledge, this study is the pioneering meta-analytic effort. It also first offers an original contribution to moderator analysis meta-analytic studies of tourist loyalty by identifying a new moderator, i.e. national culture.
Board committees and financial performance: exploring the effects of gender diversity in the emerging economy of India
Authors: Singhania Shubham , Singh Jagvinder , Aggrawal Deepti 
Published: October 2022

PurposeThis study aims to highlight the impact of introducing women directors to board committees, thereby empowering them to contribute to decision-making, and as a result, influence firms’ financial performance in an emerging economy.Design/methodology/approachThis study uses a fixed-effects panel data regression model to test the impact of gender diversity on corporate boards as well as board committees on firms’ financial performance. Two widely used diversity measures, the Blau index and the Shannon index, have been used to enhance the robustness of the results.FindingsThe findings suggest that gender diversity on prominent board committees (remuneration committee and nomination committee) positively affects firms’ financial performance when measured by the market-based performance measure, but it is insignificant when measured through accounting-based performance indicator. Furthermore, the benefits of gender diversity accrue to the firms only when women are part of prominent committees and are engaged in governance mechanisms, rather than just being appointed on corporate boards as a means of tokenism.Originality/valueThis study is among the first to investigate the relationship between gender diversity and financial performance through the lens of committee assignments. Moreover, the unique cultural and institutional setting offered by India, which is an emerging economy, provides a fertile ground for understanding the role of women leaders in the workforce.
Development of binational radiation therapy quality indicator reports for prostate cancer treatment using registry data
Authors: Chmiel Edward , Pase Marie , Evans Melanie , Johnson Maggie , Millar Jeremy , Papa Nathan 
Published: October 2022

AbstractIntroductionQuality indicators (QIs) are metrics which seek to allow comparison of clinicians' and institutes' practice to best evidence‐based practice. The Australia and New Zealand Prostate Cancer Outcomes Registry (PCOR–ANZ) is a bi‐national clinical quality registry with coverage estimated to be over 60% of the men newly diagnosed with prostate cancer. We outline the production and ambition of institute‐level QI reports to benchmark performance for radiation therapy in the treatment of prostate cancer.MethodsAn expert clinician panel was assembled to create a list of candidate QIs based on a comprehensive literature review, and on modified Delphi‐method and expert‐consensus voting. A separate implementation group—including, clinicians, epidemiologists, data managers and data scientists—employed an evidence‐ and consensus‐ based approach to generate an effective QI report designed for automated production and regular distribution to participating institutes. Feedback from the recipient clinicians was sought to enable refinement of these reports.ResultsSeven QIs, including three related to post‐treatment symptoms, were deemed feasible to analyse with the currently available data. Utilising an existing report template employed for benchmarking of surgical indicators, a novel radiation therapy report was generated using registry data in a secure analytical environment. The first, beta version of these reports have been produced and confidentially distributed. It is planned to automatically generate these reports biannually and iteratively refine them based on the clinician input.ConclusionQI reports for the treatment of prostate cancer by radiation oncologists have been produced using data from Australia and New Zealand patients. These are being disseminated to institutes on a six‐monthly basis allowing comparisons to de‐identified peers. The reports aim to facilitate improving patient outcomes, deepen engagement with the radiation oncology community and increase the breadth of PCOR–ANZ coverage. Additional QIs will be included in future iterations of these reports as data matures.
CollembolAI, a macrophotography and computer vision workflow to digitize and characterize samples of soil invertebrate communities preserved in fluid
Authors: Sys Stanislav , Weißbach Stephan , Jakob Lea , Gerber Susanne , Schneider Clément 
Published: October 2022

Abstract

Soils are inhabited by communities of tiny invertebrates that participate in the essential functions of soils. Characterizing those communities in terms of species diversity and species abundance is part of investigating soil functions and response to perturbation. Dozens to hundreds of specimens can be extracted from a sample that need to be sorted, counted and identified. It involves an enormous amount of time, straining the workflow of soil zoologists. Deep learning‐based computer vision approaches have become increasingly popular to monitor biodiversity, as they can be applied to detect, count and classify organisms.

In this work, we present CollembolAI, an open‐source prototype for a computer vision workflow. It includes a hardware system for acquiring high‐resolution pictures of soil species samples in fluid and a deep learning‐based application (Faster R‐CNN with Slicing Aided Hyper Inference) to train and evaluate models for the detection and classification of animals on those pictures. We evaluated the workflow using a mix of specimens belonging to 12 species of springtail and mite, picked from our taxonomic collection. Specimens were photographed multiple times under various angle of views. The model was trained using 5671 views on specimens on 30 images and tested on 442 views from new specimens on six images.

CollembolAI is affordable, simple to build and allows the rapid digitization of mesofauna samples. Our deep learning model achieved a Precision of 0.940, Recall of 0.918 and a mAP@0.5 (Pascal VOC) of 0.868. The model showed a lower Recall for one species, but was performant on all others.

Our prototype offers an operational workflow for the creation of soil fauna picture datasets needed to develop efficient deep learning‐based classifiers. The applications are numerous, for example, collection digitization, soil biodiversity analysis and monitoring, or automatic assessment of mesofauna‐based bioindicators. Computer vision is a rapidly emerging tool to handle efficiently the complexity of biodiversity and is already successfully used for plants and vertebrates recognition of pictures. It is on the way to become a major asset for dealing with invertebrate diversity. The code and setup instructions are available on Github.
The cytokine profiles in follicular fluid and reproductive outcomes in women with endometriosis
Authors: Han Mu‐Tian , Cheng Wei , Zhu Rui , Wu Hui‐Hua , Ding Jie , Zhao Nan‐Nan , Li Hong , Wang Fu‐Xin 
Published: October 2022

AbstractProblemEndometriosis patients undergoing in vitro fertilization‐embryo transfer (IVF‐ET) treatment suffer from poor oocyte quality, a reduced likelihood of the fertilization rate, and low embryo quality. The dysregulation of immune cells and cytokine profiles in the follicular fluid (FF) may play an important role in the competence of the oocyte and the development of the embryo, but the mechanism remains largely unknown.Method of StudyA total of 40 proved advanced staged endometriosis patients were enrolled in this study. The pregnancy results were followed until all the embryos collected by the first oocyte retrieval cycle were used up. The immune cells subtypes in FF and serum collected on the day of oocyte retrieval were detected by flow cytometry and 27 cytokines were determined using the Bio‐Plex Pro Human Cytokine 27‐Plex Immunoassay. The specific effect of cytokine on the gene expression of human granulosa cells was determined by RT‐qPCR.ResultsThe fertilization rate and the cumulative live birth rate were significantly lower in the endometriosis group. The ratio of CD4+/CD8+T cells in FF was significantly lower, while the level of IP‐10, RANTES and G‐CSF were statistically higher in the endometriosis group. The level of IP‐10 correlated with the IVF outcome. Moreover, treated by IP‐10, the mRNA level of FSHR and CYP19A1 the human granulosa cells were downregulated in vitro.ConclusionThese results suggest that alterations of the lymphocyte subsets and cytokines in women with advanced endometriosis may have an impact on the oocyte development and resulting in poorer IVF outcomes.
Does using a laser improve outcomes of conventional circumcision in adult and children populations? Results from a systematic review and meta‐analysis
Authors: Scarcella Simone , Law Yu Xi Terence , Bravi Carlo Andrea , Piazza Pietro , Heldwein Flavio L. , Ronchi Piero , Lacetera Vito , Beatrici Valerio , Gauhar Vineet , Castellani Daniele 
Published: October 2022

AbstractBackgroundMale circumcision is a well‐known old surgery, and several recently developed techniques have been scaled up, including the introduction of laser technology, as alternative approaches to overcome morbidity of conventional surgery scalpel/suture methodObjectivesWe aimed to perform a systematic review and meta‐analysis of studies comparing laser circumcision versus conventional circumcision technique in terms of perioperative outcomes and efficacy (complications, unacceptable appearance, reoperation rate) both in children and adults.Materials and methodsThis review was performed following the 2020 Preferred Reporting Items for Systematic Reviews and Meta‐Analyses framework. Continuous variables were analyzed using the inverse variance of the mean difference with a random effect, 95% confidence interval (CI), and p‐value. The incidence of complications, unacceptable appearance, and reoperation rate were pooled using the Cochran‐Mantel‐Haenszel Method with the random effect model and reported as odds ratio (OR), 95% CI, and p‐value. Significance was set at p‐value ≤0.05 and 95%CI.ResultsSeven studies were included. In comparison to the conventional circumcision, laser circumcision shoved lower visual analogue score at 24‐h, and 7 days after surgery, a lower rate of overall complication rate (OR 0.33, 95% CI 0.24–0.47, p < 0.001), scarring (OR 0.09, 95% CI 0.02, 0.41, p = 0.002), and unacceptable appearance (OR 0.09, 95% CI 0.05, 0.15, p < 0.001). We found no statistically significant difference in surgical time, and incidence of bleeding, infection, wound dehiscence, and reoperation rate.Discussion and conclusionOur review infers that laser‐assisted circumcision is certainly a safe and strong contender as the procedure of choice in both children and adult populations.
Examining potential mechanisms of testicular fibrosis in Klinefelter Syndrome: A review of current understanding
Authors: Bradshaw Aaron W. , Deebel Nicholas A. , Xu Mark C. , Kogan Stanley , Atala Anthony , Sadri‐Ardekani Hooman 
Published: October 2022

AbstractBackgroundMen with Klinefelter Syndrome develop some degree of seminiferous tubule degeneration, hyalinization, and fibrosis by adulthood. However, the pathophysiology surrounding testicular fibrosis in Klinefelter Syndrome patients remains incompletely understood.ObjectivesTo perform a systematic review of literature studying the mechanisms of fibrosis initiation or propagation in Klinefelter Syndrome testes.Materials/methodsPubMed was searched systematically for articles specific to Klinefelter Syndrome and the process of fibrosis. Articles that did not contain original data or specifically addressed the target material were excluded. Additional references were extracted when pertinent from the reference lists of included studies.ResultsPrimary search yielded 139 articles for abstract review, which was narrowed to 16 for full‐text review. Following full‐text review, eight contained original data and met topic criteria, with one paper added from reference review for a total of nine papers.DiscussionThe date range for included papers was 1992–2022. The proposed mechanisms of fibrosis mainly were centered around the impact of altered Sertoli cells on germ cells, the hormonal impact on Leydig cells, the inflammation mediated by mast cells, or the fibrous extracellular matrix deposition by peritubular myoid cells. Additionally, discussions of the role of the altered microvasculature and the specific proteins involved in the blood‐testis barrier or the seminiferous tubule architecture are reviewed. Recent papers have incorporated advanced sequencing and offer future directions for targeted gene expression analysis. Still, much of the published data consists solely of immunohistological assessment by age range, creating difficulties in extrapolating causality.ConclusionThe specific initiating factors of fibrosis of the seminiferous tubules and the propagation mechanisms unique to Klinefelter Syndrome remain incompletely understood with a relative paucity of data. Nonetheless, academic interest is increasing in this field as it may further elucidate the pathophysiology behind Klinefelter syndrome.
Putting the ‘i’ in icon: An autophotographic study of iconicity
Authors: Pötschulat Maike 
Published: October 2022

AbstractThis article addresses the potential of autophotography to generate new insights into the meanings of iconic sites. It draws on photographic and interview data collected as part of a broader study exploring the everyday urban sense‐making of university students in Liverpool, UK. Iconic sites featured prominently in participants' images of meaningful city spaces as well as the spoken accounts in the photo‐elicitation interviews. Visual depictions of urban iconicity are central to place marketing strategies attempting to attract visitors and investment. Yet on a local level, these icons and images have been criticised for alienating local populations and foregrounding lifestyles and cultures that are inaccessible to many urban residents. While we need to study icons critically, this article argues that we should not think of them reductively. The data generated here challenges understandings of icons as predominantly representational and establishes iconic sites as lived spaces that form part of everyday practices. Iconic structures are constitutive of ‘geographies of memory’ that are central to the development of a sense of place for university students. The autophotography method revealed that icons become symbols of elective belonging via which students highlight their connection to their university city beyond the more generic student infrastructure.