bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full-Thickness Scar Resection After R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery
Authors: Gijsbers Kim M. , Laclé Miangela M. , Elias Sjoerd G. , Backes Yara , Bosman Joukje H. , van Berkel Annemarie M. , Boersma Femke , Boonstra Jurjen J. , Bos Philip R. , Dekker Patty A.T. , Didden Paul D. , Geesing Joost M.J. , Groen John N. , Haasnoot Krijn J.C. , Kessels Koen , van Lent Anja U.G. , van der Schee Lisa , Schrauwen Ruud W.M. , Schreuder Ramon-Michel , Schwartz Matthijs P. , Seerden Tom J. , Spanier Marcel B.W.M. , Terhaar Sive Droste Jochim S. , Tuynman Jurriaan B. , de Vos tot Nederveen Cappel Wouter H. , van Westreenen Erik H.L. , Wolfhagen Frank H.J. , Vleggaar Frank P. , ter Borg Frank , Moons Leon M.G. ,   on behalf of the Dutch T1 CRC Working Group
Published: January 2022

INTRODUCTION:
Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.

METHODS:
A large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used. Patients were selected if they underwent a macroscopically complete local excision of a T1 CRC but positive or unassessable (R1/Rx) resection margins at histology and without lymphovascular invasion or poor differentiation. Patients treated with CS or FTRS were compared on the presence of CRC recurrence, a 5-year overall survival, disease-free survival, and metastasis-free survival.

RESULTS:
Of 3,697 patients with a T1 CRC, 434 met the inclusion criteria (mean age 66 years, 61% men). Three hundred thirty-four patients underwent CS, and 100 patients underwent FTRS. The median follow-up period was 64 months. CRC recurrence was seen in 7 patients who underwent CS (2.2%, 95% CI 0.9%–4.6%) and in 8 patients who underwent FTRS (9.0%, 95% CI 3.9%–17.7%). Disease-free survival was lower in FTRS strategy (96.8% vs 89.9%, P = 0.019), but 5 of the 8 FTRS recurrences could be treated with salvage surgery. The metastasis-free survival (CS 96.8% vs FTRS 92.1%, P = 0.10) and overall survival (CS 95.6% vs FTRS 94.4%, P = 0.55) did not differ significantly between both strategies.

DISCUSSION:
FTRS after local excision of a T1 CRC with R1/Rx resection margins as a sole risk factor, followed by surveillance and salvage surgery in case of CRC recurrence, could be a valid alternative strategy to CS.
Qualitative Validation of a Novel VR Program for Irritable Bowel Syndrome: A VR1 Study
Authors: Spiegel Brennan M.R. , Liran Omer , Gale Rebecca , Khalil Carine , Makaroff Katherine , Chernoff Robert , Raber Tiffany , Chang Bianca , Pichetshote Nipaporn , Rezaie Ali 
Published: January 2022

INTRODUCTION:
Although gut-directed psychotherapies are effective for irritable bowel syndrome (IBS), they are rarely prescribed, given a paucity of trained clinicians. Virtual reality (VR) offers a solution by allowing patients to self-practice these techniques in a standardized manner.

METHODS:
A multidisciplinary team developed IBS/VR, a program that transports users into immersive VR worlds that teach patients about the brain-gut axis, cognitive behavioral therapy, and gut-directed meditation. We tested IBS/VR in Rome IV IBS patients and used inductive analysis to evaluate perceptions and identify recommendations.

RESULTS:
We achieved thematic saturation after 9 interviews; 3 additional interviews revealed no emergent themes. After making 23 software changes based on patient feedback, we conducted 3 additional interviews which confirmed thematic saturation (N = 15 total).

DISCUSSION:
This study offers initial validation of the first VR program designed for IBS.
WOMEN’S COMMODIFICATION ON TIKTOK: A SEMIOTIC STUDY OF “ELBOW STICKING' CHALLENGE
Authors: Rully Rully , Isbandi Fitri Susiswani , Utomo Ardian Setio , Khairiyah Ade Siti , Apriani Wulan 
Published: January 2022

The use of social media has grown commonplace in today's culture. Every social media user now has a place to call their own in the digital age. Tiktok is one of the most popular and distinctive social media platforms, and it frequently abuses women through its many 'challenges' for content such as elbow sticking challange. This study takes a non-positivistic approach to the phenomena that occur in the society with a critical interpretive approach. Observations done in TikTok activities and engaging in interactions with TikTok users to be able to understand and uncover the commodification practices of women that occur in TikTok. This study revealed how intertextual the commodification of women in Tiktok was using a critical method that leverages Julia Kristeva's post-modern feminist outlook as a conceptual framework. The findings of this study reveal that the body, women, and culture are interwoven and produce meaning, which overrides earlier meanings by establishing new meanings that exploit Tiktok users, particularly women, which is consistent with media evolution, which also influences value meaning.
Czynnik „arabskiej wiosny” w stosunkach Unia Europejska–Algieria
Authors: Stachurska-Szczesiak Katarzyna 
Published: January 2022

W 10 rocznicę masowych protestów zwanych „wiosną arabską”, jakie przeszły przez państwa południowej flanki basenu Morza Śródziemnego (BMŚ), rozumienie świata staje się bardziej złożone. Dla Unii Europejskiej (UE) rewolty dokonane w państwach z nią sąsiadujących były „strategicznym zaskoczeniem” i zburzyły jej dotychczasowe założenia wobec regionu, zmuszając ją do ich rewizji i szybkiego reagowania. Dla społeczeństw arabskich były wyrazem „przebudzenia”, przełamując uczucie strachu oraz buntu wobec panujących reżimów autorytarnych, a także próbą odrzucenia neoliberalnego sposobu „urządzania świata”. Algieria zajmuje strategiczne miejsce na mapie bilateralnych relacji, jakie UE utrzymuje z państwami dotkniętymi „wiosną arabską. Bliskość geograficzna, przeszłość historyczna oraz potencjał jaki posiada to państwo sprawiają, że UE jest „na nowo” obecna w Algierii, wspierając ją w trudnej drodze przekształceń polityczno-gospodarczych.
Celem niniejszego artykułu jest analiza wpływu „wiosny arabskiej” na kształt współczesnych stosunków UE–Algieria, zwracając uwagę na ramy wyznaczone przez „Wspólne Priorytety Partnerstwa”, koncentrując się na trzech kluczowych sektorach współpracy ustalonych na lata 2018–2020.
Butterfly support for off diagonal coefficients and boundedness of solutions to quasilinear elliptic systems
Authors: Leonardi Salvatore , Leonetti Francesco , Rocha Eugenio , Staicu Vasile 
Published: January 2022

Abstract
We consider quasilinear elliptic systems in divergence form. In general, we cannot expect that weak solutions are locally bounded because of De Giorgi’s counterexample. Here we assume that off-diagonal coefficients have a “butterfly support”: this allows us to prove local boundedness of weak solutions.
Optimized operation of large scale battery systems
Authors: Lehmann Daniel , Hidalgo Rodriguez Diego , Brack Michel 
Published: January 2022

Abstract
In the decentralized renewable driven electric energy system, economically viable battery systems become increasingly important for providing grid-related services. End of 2016, STEAG has successfully started the commercial operation of six 15 MW large scale battery systems which have been incorporated in STEAG’s primary control pool. During the commissioning phase, extensive effort has been spent in optimizing the operational efficiency of these systems with promising results. However, the operation experience has shown that there is still significant potential for improving the system behavior as well as reducing the aging of the battery cells. By analyzing historical data of the charging power associated with the state of charge management, opportunities for significantly reducing the operational costs have been identified. By means of more involved model-based control strategies, which adequately consider the specific characteristics of the battery system, and by using mathematical optimization and artificial intelligence, adapting the state of charge management strategy to new applications, these additional cost savings can be obtained. Apart from giving insights into the operational experience with large scale battery systems, the contribution of this paper lies in proposing strategies for reducing the operational costs of the battery system using classical approaches as well as mathematical optimization and neural networks. These approaches will be illustrated by simulation results.
Prevalence of type 2 diabetes mellitus, metabolic syndrome, and related morbidities in overweight and obese children
Authors: Dündar İsmail , Akıncı Ayşehan 
Published: January 2022

Abstract

Objectives
The aim of the study was to determine the prevalence of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and other comorbidities in overweight and obese children in Malatya, Turkey.

Methods
Retrospective cross-sectional study. We studied 860 obese and overweight children and adolescents (obese children Body mass index (BMI) >95th percentile, overweight children BMI >85th percentile) aged between 6 and 18 years. The diagnosis of MetS, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and T2DM were defined according to modified the World Health Organization criteria adapted for children. Other comorbidities were studied.

Results
Subjects (n=860) consisted of 113 overweight and 747 obese children of whom 434 (50.5%) were girls. MetS was significantly more prevalent in obese than overweight children (43.8 vs. 2.7%, p<0.001), and in pubertal than prepubertal children (41.1 vs. 31.7%, p<0.001). Mean homeostasis model assessment for insulin ratio (HOMA-IR) was 3.6 ± 2.0 in the prepubertal and 4.9 ± 2.4 in pubertal children (p<0.001). All cases underwent oral glucose tolerance test and IGT, IFG, and T2DM were diagnosed in 124 (14.4%), 19 (2.2%), and 32 (3.7%) cases, respectively. Insulin resistance (IR) was present in 606 cases (70.5%).

Conclusions
Puberty and obesity are important risk factors for MetS, T2DM, and IR. The prevalence of MetS, T2DM, and other morbidities was high in the study cohort. Obese children and adolescents should be carefully screened for T2DM, insulin resistance, hyperinsulinism, dyslipidemia, hypertension, IGT, and IFG. The prevention, early recognition, and treatment of obesity are essential to avoid associated morbidities.
Dogmatism, Criticism, Divine Ideals: Rav A. I. Kook’s Concept of God in Light of H. Cohen
Authors: Oren Yehuda (Yady) 
Published: January 2022

Abstract
This paper examines the claim that the two final articles of Rav Kook’s book Ikvei Hatzon were written as a response to a lecture given by Hermann Cohen. It first reviews Cohen’s lecture showing that, regarding the concept of God, Cohen argues for the compatibility of Judaism and Kantianism in denying the dogmatic-mythological preoccupation with the existence of God in favor of understanding God as the basis of morality. Second, it analyzes Kook’s articles, demonstrating that he accepts the compatibility of Judaism and Kantianism together with the denial of the dogmatic relation to God as a substance. Nevertheless, Kook is not satisfied with the critical view that denies the dogmatic relation to the substance altogether, since it formulates a merely negative relationship with God. Instead, he develops his concept of the Divine Ideals, which synthesizes the dogmatic preoccupation with substantiality and the critical denial of it. The Divine Ideals are the moral progression of man, through which man gradually becomes identical to God. Within the Divine Ideals, dogmatism becomes an emotional striving to be identical with God as a substance, while criticism is the intellectual negation of the possibility of such identity, which ensures that the process will continue indefinitely.
Multi-scale Evaluation of Aging and Damage-Healing Performance of Asphalt Mixtures of Various Gradations
Authors: Cui Yanan , Li Maorong , Zhang Shuyan , Guo Jing 
Published: January 2022

Abstract
This study aimed to explore the changes in the aging and self-healing properties of styrene butadiene styrene-modified asphalt mixtures of different gradations under different aging conditions, healing temperatures, healing times, and damage degrees. The internal pore structure of the mixture was analyzed using the nuclear magnetic resonance technique. The flexural creep healing test was used, and the self-healing performance of modified asphalt mixtures of AC-13, AC-16, and SMA-13 was evaluated by calculating the cumulative dissipated energy. The results show that the original asphalt mixture with the same gradation has the largest pore size, which decreases with the degree of aging; the smallest porosity is that of thermal-ultraviolet composite aging. High temperatures can improve the fluidity of asphalt, partly filling the pores inside the asphalt mixture and thereby reducing the porosity. Furthermore, with the increase in the degree of aging and damage, the healing rate becomes slower. In addition, the healing rate of the three asphalt mixtures under different influencing factors shows that the SMA-13 asphalt mixture performs the best and the AC-13 asphalt mixture is the worst. The basalt fiber plays a bridging role, as it improves the adhesion between asphalt and other aggregates. The increase in the degree of aging reduces the deformation ability of the asphalt mixture and lowers the fluidity of the asphalt and the healing rate. The SMA-13 asphalt mixture shows better self-healing performance when applied to a bituminous pavement.
100 YEARS OF VITAMIN D: Effect of serum vitamin D level before ovarian stimulation on the cumulative live birth rate of women undergoing in vitro fertilization: a retrospective analysis
Authors: Ko Jennifer K Y , Shi Jinghua , Li Raymond H W , Yeung William S B , Ng Ernest H Y 
Published: January 2022

Objective
Vitamin D receptors are present in the female reproductive tract. Studies on the association between serum vitamin D level and pregnancy rate of in vitro fertilization (IVF) showed inconsistent results and focused on a single fresh or frozen embryo transfer cycle. The objective of our study was to evaluate if serum vitamin D level before ovarian stimulation was associated with the cumulative live birth rate (CLBR) of the first IVF cycle.

Design
Retrospective cohort study.

Methods
Women who underwent the first IVF cycle from 2012 to 2016 at a university-affiliated reproductive medicine center were included. Archived serum samples taken before ovarian stimulation were analyzed for 25(OH)D levels using liquid chromatography-mass spectrometry.

Results
In total, 1113 had pregnancy outcome from the completed IVF cycle. The median age (25th–75th percentile) of the women was 36 (34–38) years and serum 25(OH)D level was 53.4 (41.9–66.6) nmol/L. The prevalence of vitamin D deficiency (less than 50 nmol/L) was 42.2%. The CLBR in the vitamin D-deficient group was significantly lower compared to the non-deficient group (43.9%, 208/474 vs 50.9%, 325/639, P  = 0.021, unadjusted), and after controlling for women’s age, BMI, antral follicle count, type and duration of infertility. There were no differences in the clinical/ongoing pregnancy rate, live birth rate and miscarriage rate in the fresh cycle between the vitamin D deficient and non-deficient groups.

Conclusions
Vitamin D deficiency was prevalent in infertile women in subtropical Hong Kong. The CLBR of the first IVF cycle in the vitamin D-deficient group was significantly lower compared to the non-deficient group.
Microbiological quality aspects of ready-to-eat foods with focus on antibiotic resistance and biofilm formation abilities of foodborne bacteria
Authors: Aksoy D. 
Published: January 2022

AbstractIn this study, microbiological quality of 93 ready-to-eat food products was determined by enumeration of total aerobic bacteria and members of Enterobacteriaceae. Presence of Staphylococcus aureus and Listeria monocytogenes in the products were also investigated. Aerobic colony counts were between 1.9 × 102–3.4 × 108 CFU g−1 for 84.9% and Enterobacteriaceae counts were between 2 × 102 and 6.7 × 106 CFU g−1 for 43% of the samples. S. aureus was detected in 7.5% of the samples, but L. monocytogenes was not detected in any sample. 72.9% of the Enterobacteriaceae isolates showed resistance to at least one antibiotic tested, and 5 among the S. aureus isolates were found to be resistant to penicillin G and 2 against methicillin. Four S. aureus isolates produced only Staphylococcal enterotoxin A and 1 isolate produced both Staphylococcal enterotoxin A and B. Biofilm experiments revealed biofilm formation on polystyrene for 95.8%, 87.5%, and 91.6% of Enterobacteriaceae isolates at 4 °C, 22 °C, and 37 °C, respectively, whereas all S. aureus isolates formed biofilm at all temperatures.
Presidential politics of constitutional amendment in Francophone Africa: The case of Senegal
Authors: Jakubiak Łukasz 
Published: January 2022

Abstract
The paper is devoted to the role of the head of state in initiating and implementing constitutional reforms in Senegal. This country can legitimately be regarded as one of the few examples of a relatively successful democratization process in Africa, as evidenced, among other things, by the lack of military coups leading to the loss of power by civilian governments, as well as by two democratic transfers of power (in 2000–2001 and 2012), after which the main opposition parties gained the presidency and the majority of parliamentary seats. Both these fundamental political transformations generated important constitutional changes (for example, the adoption of the current Constitution of 2001, or the constitutional modifications of 2016 and 2019) that have influenced, to a greater or lesser extent, the position of the presidency in Senegalese systems of government. The author analyses their significance for the functioning of contemporary political institutions in the broader context set by the politics of constitutional amendment which was conducted by previous presidents of this country. The main goal of the paper is to examine to what extent the constitutional modifications introduced before and after the adoption of the 2001 Constitution were designed to contribute to the beginning or consolidation of pro-democratic trends, and to what extent they were created to strengthen the position of an incumbent president himself, leading to a political imbalance and regress in the democratization process. The author argues that the constitutional modifications adopted over the years have often gone in two opposite directions, influencing the efficiency and durability of Senegalese institutional structures.
Gyermekkori indolens lymphomák differenciáldiagnosztikája
Authors: Burján Adrienn , Nagy Dóra , Kereskai László , Kajtár Béla , Vida Livia 
Published: January 2022

Összefoglaló.
Bevezetés: A gyermekkorban előforduló hematológiai
megbetegedések közül az indolens non-Hodgkin-lymphomák igen ritka entitásnak
számítanak. A betegség általában körülírt nyirokcsomó-megnagyobbodással
jelentkezik, mely jellemzően lokalizált marad, szisztémás tünetek megjelenése
nélkül, a prognózis kifejezetten kedvező. Morfológiai képük igen változatos, ami
miatt gyakran differenciáldiagnosztikai kihívást jelentenek. Sajátos
klinikopatológiai megjelenésük és rendkívül kedvező gyógyhajlamuk miatt a
2016-os WHO klasszifikációban önálló entitásként szerepelnek, mint
gyermekkori-típusú follikuláris lymphoma és gyermekkori nodális marginális zóna
lymphoma. Jelen tanulmányunk célja volt átfogó képet adni a gyermekkori indolens
lymphomákról, különös hangsúlyt fektetve a differenciáldiagnosztikai
problematikára. Közleményünkben részletes ismertetésre kerülnek az egyes
szövettani típusok, morfológiai, immunhisztokémiai, klinikai és genetikai
jellemzők szerint.
Summary.
Introduction: Indolent non-Hodgkin lymphomas in the pediatric
and young adult population are very rare. The disease usually presents as
isolated, localized lymphadenopathy most often in the head and neck regions,
without generalized symptoms. The histology mainly shows mature B-cell lymphoma
phenotypes, distinction from reactive lymphoid hyperplasias can be often
difficult. Pediatric indolent lymphomas show characteristic clinicopathological
features with excellent prognosis that differ from the adult counterpart; these
lymphomas can be found as a distinct entity in the 2016 WHO classification as
the pediatric-type follicular lymphoma and the pediatric-type nodal marginal
zone lymphoma. In this study we present the pathologic characteristics:
morphology, immunophenotype and genetical features and the important
differential diagnostics of these entities.
Influence of tin doping on the liquefied petroleum gas and humidity sensing properties of NiO nanoparticles
Authors: Gupta Priya , Kumar Kuldeep , Saeed Syed Hasan , Pandey Narendra Kumar , Verma Vernica , Singh Peramjeet , Yadav Bal Chandra 
Published: January 2022

Abstract
This research deals with study of enhanced liquefied petroleum gas (LPG) and humidity sensing properties of Sn-doped NiO pellets synthesized by chemical precipitation route. XRD, FTIR, SEM, and UV–Vis studies were employed to understand the effect of Sn doping on the structural, morphological, and optical properties of the NiO nanoparticles. XRD results revealed that doping of tin in NiO had a significant impact on the crystallite size, peak intensity, strain, lattice parameter, etc. The calculated crystallite size of pure and 3 mol% doped NiO was 33.2 nm and 13.3 nm, respectively. SEM micrographs revealed that the structure of the samples was irregular spheres and non-homogeneous. The dependence of LPG sensing properties on the structural and surface morphological properties has also been studied. The maximum response of 30.46% to 2.0 vol% of LPG was observed at room temperature (300 K). The same sample also shows high humidity sensing response of 87.11% towards 90% RH.

Graphic abstract
INDUSTRIALITATION EFFECTS IN GEORGE ORWELL’S THE ROAD TO WIGAN PIER (1937)
Authors: Bangkit Afina Aji , Jamaludin Yusup 
Published: January 2022

To see industrialization effects in England, this research focused on a literary work of an essay. The book can describe and express what happened in the reality. This research focuses on the book to know Industrialization effects on George Orwell The Road to Wigan Pier. The Road to Wigan Pier written in 1937 tells the experience, notes, and ideas from George Orwell when he walked down the slums area in England. In order to reveal the ideology within the book, this research uses qualitative research to interpret the data. The data were collected through purposive sampling, namely focusing on the data that concerns the industrialization encountered in the elements of the book. As a result, George Orwell divided his work into two parts. The first part content about George Orwell notes when he walked down the slums area in England. He describes slums condition, the lodging that he occupies, the state of miners condition, poverty, and unemployment. In the second part content about George Orwell idea and his critic of industrialization effects and the failure of socialism and his perspective on socialism, his opinion about socialism that the real socialist is people who actively want to see tyranny is destroyed and not only imagine that matters only to want. Keywords: Industrialization; Industrialization effects; socialism