bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study to compare the Possible Efficacy and Safety of casirivimab and imdevimab combination versus standard antiviral therapy in hospitalized COVID-19 patients
Authors: Hassan Ahmed H. , Hegazy Sahar K. , Radwan Smar T. 
Published: September 2022

Abstract
Introduction:
Corona Virus induced disease – 2019 (COVID-19) disaster motivates scientific research to find a settling to this pandemic. With ending of 2021 year, various advances in immunotherapy against COVID-19 have emerged.
Regarding antiviral therapy, Casirivimab and imdevimab antibody combination is a type of new immunotherapy against COVID-19. Other antiviral therapy against COVID-19 includes Remdesivir and Favipravir.
Aim of Study:
To compare the efficacy and safety of casirivimab and imdevimab, Remdesivir and Favipravir as antiviral agents in hospitalized COVID19 patients.
Patients and Population:
265 COVID-19 Polymerase Chain Reaction (PCR) positive patients are included in this study and will be assigned into 3 groups in a ratio of (1:2:2):
1- Group A: REGN3048-3051
2-group B: Remdesivir
3-group C: Favipravir
Methods:
Study design is single blind non-Randomized Controlled Trial (non-RCT). The duration of study is about 6 months after ethical approval.
Results and discussion:
Casirivimab and imedivimab achieves less 28-day mortality rate, less mortality at hospital discharge, more negative swab cases than Remdesivir and Favipravir.
Conclusion:
the results show that Group A (Casirivimab & imedivimab) achieves more favorable clinical outcomes than B (remdesivir) & C (favipravir) groups.
Mosaicism detection and impact in eye development anomalies
Authors: Plaisancié Julie , Chesneau Bertrand , Ivashchenko Véronique , Habib Christophe , Gaston Véronique , Escudié Frédéric , Morel Godelieve , Capri Yline , Vincent-Delorme Cathrine , Calvas Patrick , Chassaing Nicolas 
Published: September 2022

Abstract
Micro-anophthalmia and Coloboma (MAC) form a spectrum of congenital eye malformations responsible for severe visual impairment. Despite the exploration of hundreds of genes by High-Throughput Sequencing (HTS), most of the patients remain without genetic diagnosis. One explanation could be the not yet demonstrated involvement of somatic mosaicism (undetected by conventional analysis pipelines) in those patients. Furthermore, the proportion of parental germline mosaicism in presumed de novo variations is still unknown in ocular malformations. Thus, using dedicated bioinformatics pipeline designed to detect mosaic variants, we reanalyzed the sequencing data obtained from a 119 ocular development genes panel performed on blood samples of 78 probands with sporadic MAC without genetic diagnosis. Using the same HTS strategy, we sequenced the asymptomatic parents of 41 probands carrying a disease-causing variant in an ocular development gene considered de novo after direct Sanger sequencing of both parents. Reanalysis of previously sequenced data did not find any mosaic variant in probands without genetic diagnosis. However, HTS of parents revealed undetected SOX2 and PAX6 mosaic variants in two parents. Finally, this work, performed on two large cohorts of patients with MAC spectrum or their parents, provides for the first time an overview of the interest of looking for mosaicism in ocular development disorders. Somatic mosaicism does not appear to be frequent in MAC spectrum and might explain only few diagnoses. Thus, other approaches such as whole genome sequencing should be considered in those patients. Parental mosaicism is however not that rare (around 5%) and challenging for genetic counselling.
Effects of Surface Irradiation on the Performance of CdZnTe-based Nuclear Detectors
Authors: Babalola Stephen O , Bolotnikov Aleksey , Camarda Giuseppe , Muntele Claudiu 
Published: September 2022

Abstract
CdZnTe (CZT) has emerged as a viable material for room temperature radiation detection applications in both bulk and pixelated configurations, however In this work we have modified CZT crystal surface, and hence the metal-semiconductor interface, by irradiating the surface with Yb 3+ ions at 5 MeV. At this energy we obtained ion implantation depth of ~1 micron and 0.05 ppm doping concentration by implanting 10 17 Yb ions per cm 3 of CZT crystal. We compared the characteristic properties and performance of the detector before and after ion irradiation. The resistivity of the bulk CdZnTe was found to be 2.45 x 10 10 ohm-cm. We employed low energy synchrotron X-rays to generate detector response map of both irradiated and non-irradiated regions of the CZT crystal. We observed non-uniform detector response in the irradiated regions. We also compared the response of both irradiated and non-irradiated CZT detectors to 241 Am. The irradiation process caused near-surface damages, which has little effect on the total active volume of the detector.
Valorization of Polypropylene Fibers to Improve the Physical and Mechanical Properties of Concrete and Mortars
Authors: Noufid Abdelhamid , Hidar Nadia , Feddaoui M’barek , Elafi Mohamed 
Published: September 2022

Abstract
Green construction, also called sustainable construction or green construction, offers various possibilities in order to reduce the ecological impact of buildings. The use of factory waste in construction is a means of recovering this waste and also a method of protecting the environment, more precisely against the harmful effects on flora and fauna. In this work, we study the reuse and recovery of waste polypropylene fibers which are wastes from factories manufacturing furniture products. The objective of this work is the valuation of polypropylene fibers in the manufacture of concretes and mortars. The aim is to investigate the impact of adding polypropylene fibers to the concrete and mortar in order to improve the mechanical properties. In order to measure the compressive and tensile strengths of concrete at ages of 3 days, 7 days and 28 days and the characteristics of adhesion of the mortar. The results obtained are compared with an ordinary concrete and mortar. According to this study an optimal addition of the polypropylene fibers allows an increase in the mechanical characteristics of the concretes and the mortars. This increase can reach 12% of the compressive strength at the age of 28 days. In order to enhance this work, we will try to compare the results with thorough research that has been carried out.
Machine learning–based construction of a clinical prediction model for hypercapnia during one-lung ventilation for lung surgery
Authors: Fan Yiwei , Ye Ting , Huang Tingting , Xiao Huaping 
Published: September 2022

Abstract
In this study, we developed a clinical prediction model for hypercapnia during one-lung ventilation for lung surgery by machine learning. We analyzed the cases and intraoperative blood gases of 348 patients who had undergone lung surgery at Jiangxi Cancer Hospital from November 2019 to June 2021. We analyzed the factors that independently influence hypercapnia during one-lung ventilation for lung surgery by selecting the best variables through a combination of random forest and logistic regression stepwise selection (Step AIC). Thereafter, we used these factors to construct logistic regression models and a nomogram. Receiver operating characteristic curves were used to measure the predictive accuracy of the nomogram and its component variables, and the predictive probabilities of the nomogram were compared and calibrated by calibration curves. We used bootstrap to verify the internal validation method to judge the reliability of the model, and we employed decision curve analysis (DCA) for clinical decision analysis. The independent influencing factors for hypercapnia during one-lung ventilation for lung surgery were age, gender, and one-lung ventilation position. We established the hypercapnia during one-lung ventilation for lung surgery logistic regression model: −5.421 + 0.047 × age + 1.8 × gender (=1) + 0.625 × one-lung ventilation position (=1). The prediction accuracy probability of the nomogram is 0.7457 (95% confidence interval [0.6916, 0.7998]). The prediction model showed good agreement between the calibration curve and the ideal predicted value, and bootstrap internal validation showed the area under the curve was 0.745 and the C-index was 0.742. DCA indicated that the model has some clinical value. In this study, three independent influences on hypercapnia during one-lung ventilation were established. We constructed an individualized model for predicting hypercapnia during one-lung ventilation for pulmonary surgery, as well as the first internally validated predictive model and nomogram for hypercapnia during one-lung ventilation for pulmonary surgery, both of which have good predictive and calibration properties and can provide some clinical guidance value.
Long-term effects of the COVID-19 pandemic on five mental and psychological disorders: in terms of the number of disease visits, drug consumption, and scale scores.
Authors: Zhu Hanyu , Guo Yimo , Pan Zhiming , Wang Yan , Zhang Mengli , Zhu Ruhuang , Li Zhangping , Wang Zhen 
Published: September 2022

Abstract
Background:COVID-19 caused mild to severe infections in humans. The long-term epidemic environment harms people's mental health. To explore the impact of the epidemic on people's mental and psychological conditions, we surveyed in Wenzhou.
Methods: We collected the data of people who visited the First Affiliated Hospital of Wenzhou Medical University for five types of mental and psychological diseases from January 2018 to December 2021. Then, taking December 2019 as the cut-off point, the 48-month data were divided into the pre-epidemic group and the dur-epidemic group. Based on the above data, statistical analysis was done.
Results: From 2018 to 2021, the number of initial diagnoses, the number of disease visits, and drug consumption for these five types of mental and psychological diseases were all on the rise. Compared with the number of disease visits for all disorders in both psychiatry and neurology departments, it was found that the growth rate of these five diseases was higher than the growth rate of all disorders. We found that the number of disease visits, drug consumption, and scale scores after the COVID-19 outbreak were significantly different from those before the outbreak (P<0.05). And the number of disease visits positively correlated with drug consumption (P<0.0001, r=0.9503), which verified the stability of the data.
Conclusion: The epidemic environment has had a long-term and negative impact on people's mental and psychological conditions. Therefore, whether or not the epidemic is receding, we still need to be concerned about the impact of COVID-19 on mental and psychological health.
NNMT-LOX-FAK axis orchestrates the intergrowth of fibroblasts and tumor cells in oral squamous cell carcinoma: evidence from the patient-derived assembled organoids
Authors: Shang Zhengjun , Zhao Hui , Li Rui , Chen Yang , Yang Xiao 
Published: September 2022

Abstract
Nicotinamide N-methyltransferase (NNMT) has been reported to link with the methylation reprogramming in cancer cells. However, the role of NNMT in tumor microenvironment (TME) remained elusive. Here, we found that the expression of NNMT was elevated in the stroma of oral squamous cell carcinoma (OSCC). Using a fibroblast-attached organoids (FAOs) model, we found that the stromal NNMT expression contributed to the generation of assembled tumor organoids. In tumor regeneration assay with co-implanted OSCC cells and cancer-associated fibroblasts (CAFs), the tumor-initiating activity was reduced when NNMT in CAFs was silenced. On the contrary, overexpression of NNMT in paracancerous fibroblasts (PFs) accelerated the tumor growth in co-inoculation experiments. Of note, the fibroblast-specific NNMT can regulate the type I collagen deposition in both FAOs and xenograft. Further investigations confirmed that the stromal NNMT-aggravated oncogenic properties were attenuated by treatment with inhibitors targeting either the type I collagen synthesis (e.g. losartan, tranilast, halofuginone), or the focal adhesion kinase (FAK) signal (i.e. defactinib). Mechanistically, overexpression of NNMT reduced the enrichment of H3K27me3 at the promoter of gene encoding lysyl oxidase (LOX), a key enzyme that regulates cross-link formation of type I collagen. Overall, we propose that NNMT-LOX-FAK axis is essential for the intergrowth of cancer cells and fibroblasts during OSCC development, and the NNMT-centric extracellular matrix remodeling is supposed to be a novel therapeutic target for patients with OSCC.
Adverse perinatal outcomes associated with prenatal exposure to protease- inhibitor-based versus non-nucleoside reverse transcriptase inhibitor-based antiretroviral combinations in pregnant women with HIV infection: a systematic review and meta-analysis
Authors: Saint-Lary Laura , Benevent Justine , Damase-Michel Christine , Vayssière Christophe , Leroy Valériane , Sommet Agnès 
Published: September 2022

Abstract
Background: About 1.3 million pregnant women lived with HIV and were eligible to receive antiretroviral therapy (ART) worldwide in 2021. The World Health Organization recommends protease inhibitors (PI)-based regimen as second or third-line during pregnancy. With remaining pregnant women exposed to PIs, there is still an interest to assess whether this treatment affects perinatal outcomes. Adverse perinatal outcomes after prenatal exposure to PI-based ART remain conflicting: some studies report an increased risk of preterm birth (PTB) and low-birth-weight (LBW), while others do not find these results. We assessed adverse perinatal outcomes associated with prenatal exposure to PI-based compared with non-nucleoside reverse transcriptase (NNRTI)-based ART.
Methods: We performed a systematic review searching PubMed, Reprotox, Clinical Trial Registry (clinicaltrials.gov) and abstracts of HIV conferences between 01/01/2002 and 29/10/2021. We used Oxford and Newcastle-Ottawa scales to assess the methodological quality. Studied perinatal outcomes were spontaneous abortion, stillbirth, congenital abnormalities, PTB (<37 weeks of gestation), very preterm birth (VPTB, <32 weeks of gestation), LBW (<2500 grs), very low-birth-weight (VLBW, <1500g), small for gestational age (SGA) and very small for gestational age (VSGA). The association between prenatal exposure to PI-based compared to NNRTI-based ART was measured for each adverse perinatal outcome using random-effect meta-analysis to estimate pooled relative risks (RR) and their corresponding 95% confidence intervals (CI). Pre-specified analyses were stratified according to country income and study quality assessment, and summarized when homogeneous.
Results: Out of the 49,171 citations identified, our systematic review included 32 published studies, assessing 45,427 pregnant women. There was no significant association between prenatal exposure to PIs compared to NNRTIs for VPTB, LBW, SGA, stillbirth, and congenital abnormalities. However, it was inconclusive for PTB, and PI-based ART is significantly associated with an increased risk of VSGA (sRR 1.41 [1.08-1.84]; I2=0%) compared to NNRTIs.
Conclusions: We did not report any significant association between prenatal exposure to PIs vs NNRTIs-based regimens for most of the adverse perinatal outcomes, except for VSGA significantly increased (+41%). The evaluation of antiretroviral exposure on pregnancy outcomes remains crucial to fully assess the benefice-risk balance, when prescribing ART in women of reproductive potential with HIV.
PROSPERO number: CRD42022306896.
Interleukin-18-primed human umbilical cord-mesenchymal stem cells achieve superior therapeutic efficacy for severe viral pneumonia via enhancing T-cell immunosuppression
Authors: Cai Cheguo , Liao Yan , Fu Zeqin , Huang Yinfu , Wu Shiduo , Wang Zhen , Ye Shaotang , Zeng Weijie , Zeng Guifang , Li Duanduan , Yang Yulin , Pei Ke , Yang Jian , Hu Zhiwei , Liang Xiao , Hu Junyuan , Liu Muyun 
Published: September 2022

AbstractCoronavirus disease 2019 (COVID-19) treatments are still urgently needed for critically and severely ill patients. Human umbilical cord-mesenchymal stem cells (hUC-MSCs) infusion has therapeutic benefits in COVID-19 patients; however, uncertain therapeutic efficacy has been reported in severe patients. In this study, we selected an appropriate cytokine, IL-18, based on the special cytokine expression profile in severe pneumonia of mice induced by H1N1virus to prime hUC-MSCsin vitroand improve the therapeutic effect of hUC-MSCsin vivo.In vitro, we demonstrated that IL-18-primed hUC-MSCs (IL18-hUCMSC) have higher proliferative ability than non-primed hUC-MSCs (hUCMSCcon), and there was no significant difference in their migration capacity. In addition, VCAM-1, MMP-1, TGF-β1, and some chemokines (CCL2 and CXCL12, for example) are more highly expressed in IL18-hUCMSCs. We found that IL18-hUCMSC significantly enhanced the immunosuppressive effect on CD3+T-cells.In vivo, we demonstrated that IL18-hUCMSC infusion could reduce the body weight loss caused by a viral infection and significantly improve the survival rate. Of note, IL18-hUCMSC can also significantly attenuate certain clinical symptoms, including reduced activity, ruffled fur, hunched backs, and lung injuries. Pathologically, IL18-hUCMSC transplantation significantly enhanced the inhibition of inflammation, viral load, fibrosis, and cell apoptosis in acute lung injuries. Notably, IL18-hUCMSC treatment has a superior inhibitory effect on T-cell exudation and proinflammatory cytokine secretion in bronchoalveolar lavage fluid (BALF). Altogether, IL-18 is a promising cytokine that can prime hUC-MSCs to improve the efficacy of precision therapy against viral-induced pneumonia, such as COVID-19.
Predictors of subclinical atherosclerosis in HIV
Authors: Soto Julia Fernández , Romero-Jiménez Manuel Jesús , García José Carlos Alarcón , Estruch Elena Bonet , Ramos José Luís Sánchez , López Miguel Ángel Castaño 
Published: September 2022

Abstract
Background: Cardiovascular disease is a major cause of morbidity and mortality in HIV patients.
The detection of subclinical atherosclerosis through vascular ultrasound allows us to identify patients at increased risk of cardiovascular disease as a primary prevention strategy; this test is not routine.
Our objective is to determine predictors of subclinical atherosclerosis in a population with HIV.
Methods: Patients with HIV infection were selected in primary prevention and underwent carotid and femoral ultrasound to detect atheromatous plaques. Logistic regression analysis was performed including vascular risk factors to predict the presence of atherosclerosis.
Results: One hundred eighty-three patients were included. Subclinical atherosclerosis was present in 62.29% of the patients; 83.32% had plaque in the carotid territory, 57.93% in the femoral territory and 25.6% in both vascular territories. Compared to those without atherosclerosis, patients with atherosclerosis were on average 5.35 years older (53.86 vs. 48.51, p<0.001) and had a higher prevalence of smoking (63.23% vs. 39.12%, p=0.020) and a CD4/CD8 ratio below 0.7 (44.23% vs. 29.02%, p=0.043). A CD4/CD8 ratio lower than 0.3 was always associated with subclinical atherosclerosis (95% CI: 83.9-100%).
Inclusion of smoking, CD4/CD8 ratio and age in the logistic regression analysis led to a diagnostic yield of 72% measured by the area under the ROC curve (95% CI: 64-80%).
Conclusions: Tobacco use, age and a CD4/CD8 ratio lower than 0.7 allow prediction of the presence of subclinical atherosclerosis in primary prevention.
A CD4/CD8 ratio below 0.3 was diagnostic of atherosclerosis in HIV patients in primary prevention.
Trial registration
Not applicable
DRIFT spectroscopic determination of clay and organic matter in sediment by mixed soil-sediment calibration approach
Authors: Jović Branislav , Maletić Snežana , Kordić Branko , Beljin Jelena 
Published: September 2022

Abstract
Bioavailability and movement of pollutants through land and underground flows are strongly related to some of the sediment characteristics, such as clay minerals and organic matter. Therefore, the determination of clay and organic matter content in sediment is of great importance for environmental monitoring. Clay and organic matter in sediment were determined using diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy in combination with multivariate analysis methods. Sediment from different depths was used in combination with the soil samples of different texture. Using multivariate methods and DRIFT spectra, sediments from different depths were successfully grouped according to similarity to different texture soils. Also, a quantitative analysis of clay and organic matter content was performed, where a new calibration approach was used in which sediment samples combined with soil samples were used for principal component regression (PCR) calibration. PCR models for the assessment of clay and organic matter were determined for a total of (57 sediment samples and 32 soil samples) and satisfactory determination coefficients were obtained for linear models (0.7136 for clay and 0.7062 for organic matter). The obtained RPD values for both models gave very satisfactory values of 1.9 for clay i.e., 1.8 for organic matter.
Gastric Plication Failure: A retrospective analysis
Authors: Nassar Ricardo M , Girón Felipe , Rodríguez Lina M , Rey Carlos , Venegas David , Vanegas Marco , Conde Danny , Ricaurte Alberto , Núñez-Rocha Ricardo E. , Hernández Juan David 
Published: September 2022

Abstract
Background
Obesity has evolved into a worldwide disease affecting millions of patients. This condition is related to a wide variety of health problems such as diabetes, hypertension, aterosclerotic disease, among others. There is a wide range of methods for managing obesity, varying from medical to surgical interventions. Even though bariatric surgery is not a one size fits all solution, since its advenment it has become an excellent option for those living with obesity. Although its low cost is very appealing, the high need of re-intervention and complications (70% according to literature) have led to controversy surrounding the use of gastric plication. The aim of this study is to describe the characteristics, experience and outcomes of patients with history of gastric fundoplication that required reintervention between 2014 and 2020 in our institution.
Methods
We conducted a retrospective observational study with a prospective database. We included patients that developed complications from a previous gastric plication. Revision to laparoscopic sleeve gastrectomy was made. Data regarding baseline and evolution were obtained and analyzed. Revision cause, perioperative outcomes, intraoperative characteristics, complications and weight loss were variables included in the surgical analysis. Post-operative follow-up was done up to 5 years.
Results
Seventeen patients required revisional surgery. Mean age of the patients was 39.71 years, 52.9% were men and 47.1% were women. In the first consultation the main concerns were weight regain (88.2%), and abdominal pain (82.3%). 47% of the patients reported dyspepsia and 47.1% had symptoms related to nausea and emesis. Mean body mass index in the group was 31.2 kg/m² before reintervention, 27.6 kg/m² 6 months after surgery and 24.1 kg/m² 5 year after surgery. All the patients had abdominal adhesions as intraoperative findings, 41.17% had severe inflammation and 1 patient (5.8%) had a gastroesophageal fistula.
Conclusions
In our series, gastric plication failure was mainly associated with abdominal pain and weight regain. Revisional surgery proved to be a safe and effective alternative for management of complications after this procedure.