bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissimilar Joining of UHWMPE and PP Using Friction Stir Welding (FSW), and Mechanical Properties Evaluation.
Authors: MIRANDA Mario Alberto SANCHEZ , ALMARAZ Gonzalo Mariano DOMINGUEZ , LOPEZ Juan Jesús VILLALON , DOMINGUEZ Aymeric Edouard , VILCHEZ Julio Adrían RUIZ , JUAREZ Julio Cesar VERDUZCO 
Published: April 2022

Abstract
This work presents the results of the Friction Stir Welding (FSW) for two dissimilar thermoplastic polymers: Polypropylene (PP) and ultra-high molecular weight polyethylene (UHMWPE), under butt welding position. The preliminary results show poor welding, consequently, bad mechanical properties; nevertheless, introducing a self-designed and constructed fixed aluminum shoulder and determination of the best FSW parameters, such as advance speed, rotation speed, preheating or no preheating, leads to an improvement on the welding results. Tensile tests for the welded dissimilar specimens PP-UHMWPE, have revealed as high as 80% of welding efficiency in regard the original base materials. Furthermore, measures of microhardness along the welded zone and around were performed; together with the analysis of fracture behavior under tensile tests, in order to deduce the generalities of effect-cause in the improvement of mechanical properties, which are related to the glassy transition temperature of both thermoplastics, the molecular diffusion in liquid state and the process parameters.
Perineal ultrasound to assess the urethral spatial movement in stress urinary incontinence in women
Authors: Dong Binbin , Shi Yingqiu , Chen Yin , Liu Ming , Lu Xiaoming , Liu Yadong 
Published: April 2022

Abstract
Background: To evaluate characteristics of the urethral mobility with perineal ultrasonography.Methods: A total of 136 female patients with stress urinary incontinence and 44 controls were enrolled. Stress urinary incontinence was diagnosed using the International Consultation on Incontinence Questionnaire Short Form, medical history and physical examination, and severity was assessed using a 1-hour pad test. We described the mobility of four equidistant points (A to D) located along the urethra length. The retrovesical and urethral rotation angles were measured using perineal ultrasonography at rest and during the maximal Valsalva maneuver. Results: Patients with stress urinary incontinence showed a more significant vertical movement at Points A and B than controls. The mean variations in the retrovesical angle were significantly larger in patients with stress urinary incontinence at rest and during the Valsalva maneuver than in controls (21.0±16.5° vs. 14.7±20.1°, respectively). The cut-off value for the retrovesical angle variation was 10.7° with 72% sensitivity and 54% specificity. There was a receiver-operating characteristic curve area of 0.73 and 0.72 for Points A and B, respectively. A cut-off of 10.8 mm, and 9.4 mm provided 71% sensitivity and 68% specificity and 67% sensitivity and 75% specificity, respectively. Conclusions: The horizontal and vertical direction movement of the bladder neck and proximal urethra, and variations in the retrovesical angle may be correlated with clinical symptoms and facilitate to the assessment of SUI.
Assessing mental health of elderly outpatients, to screen only dementia or depression will have a strong bias
Authors: Lin Yen-Kuang , Lee Yao-Tung , Lee Hsin-Chien , Huang Li-Kai , Chao Shu-Ping , Lin Yi-Jung , Chi Mei-Ju 
Published: April 2022

Abstract
Background: Dementia and depression have emerged as two of the major mental health concerns for elderly people, which are likely to substantially affect public health in the coming decades. Both dementia and geriatric depression are associated with increased morbidity, health care utilization, and mortality. Early detection and treatment initiation are some of the best strategies to minimize the ill effects of dementia and depression on the elderly people. To this end, large-scale screening may be the first step.Methods: Screening of individuals ≥65 years old was conducted in the outpatient department of a university hospital. Ascertainment of dementia 8 (AD8) and five-item Brief Symptom Rating Scale (BSRS-5) were used to screen for cognitive decline and depression, respectively.Findings: In total, 3079 elderly people completed both AD8 and BSRS-5. Patients tested positive for cognitive impairment and depression were 28.2% and 15%, respectively. However, 7% were tested positive by both AD8 and BSRS-5 and with statistical significance.Interpretation: The high ratio of suspected dementia and suspected depression suggested the needs and cost-effect of screening among the elderly outpatients. However, the statistically significant overlap implied potential bias when screening only one condition. Future screening program of geriatric mental health needs to consider this.
A flexible and stretchable photonic crystal sensor for biosensing and tactile sensing
Authors: Peng Wang , Huang Bing , Huang Xuanxuan , Song Han , Liao Qingxi 
Published: April 2022

Abstract
A flexible and stretchable photonic crystal that can be used for biosensing and tactile sensing is designed and demonstrated. The nanograting of a flexible and stretchable photonic crystal was fabricated using the nanoreplica molding method with a Si master wafer. The flexible and stretchable photonic crystal consists of PDMS (Polydimethylsiloxane) as the substrate and TiO2 as the high refractive index (RI) layer. The flexible and stretchable photonic crystal was used for strain sensing and biosensing. When the flexible and stretchable photonic crystal was stretched by 0.1%, the peak resonance wavelength shifted 0.4 nm. Also, a refractive index sensitivity of 93 nm/RIU was obtained for biosensing. The proposed flexible and stretchable photonic-crystal-based sensor can be used in the areas of tactile sensing and biosensing in the future.
Safety/feasibility study of pedicle screws coated with a fibroblast growth factor-2-calcium phosphate composite layer for posterior cervical fusion surgery
Authors: Nagashima Katsuya , Hara Yuki , Mutsuzaki Hirotaka , Totoki Yasukazu , Okano Eriko , Mataki Kentaro , Matsumoto Yukei , Yanagisawa Yohei , Noguchi Hiroshi , Sogo Yu , Ito Atsuo , Koda Masao , Yamazaki Masashi 
Published: April 2022

Abstract
To solve the instrument loosening problem, we developed a fibroblast growth factor-2-calcium phosphate composite layer as a novel coating material to improve screw fixation strength. The primary aim of the present study was to demonstrate the safety and feasibility of screws coated with the FGF-2-calcium phosphate composite layer for posterior instrumented surgery of the cervical spine. The trial design was a single-arm, open-label, safety and feasibility study. Patients receiving fusion of the cervical spine from C2 (or C3) to C7 (or T1) were recruited. The primary endpoint to confirm safety was any screw-related adverse events. Seven patients who underwent posterior fusion surgery of the cervical spine were enrolled in the present study. The coated pedicle screws were inserted bilaterally into the lowest instrumented vertebrae. There was only one severe adverse event unrelated with the coated screw”. Three out of the 14 coated screws showed loosening. The present results prove the safety and feasibility of pedicle screws coated with the FGF-2-calcium phosphate composite layer for fusion surgery in the cervical spine. This is the first step to apply this novel surface coating in the field of spine surgery.
Right atrial function index is an independent predictor of functional status in patients with pulmonary hypertension
Authors: Li Yi-dan , Guo Di-chen , Hu Hui-min , Zhang Xin-yuan , Yang Yuan-hua , Gong Juan-ni , Lu Xiu-zhang 
Published: April 2022

Abstract
Objectives: Right atrium (RA) plays an essential role in modulating right ventricular (RV) function. RA dysfunction is associated with poor survival in patients with pulmonary hypertension (PH). Right atrial function index (RAFI) which is defined as (RAEF×RVOT-VTI)/(RAVmax index) represents an easily obtainable echocardiographic variable of RA function assessment, synthesizing expressions of RA size, RA reservoir function and cardiac output. The purpose of our study was to evaluate RAFI and explore its association with functional status in PH subjects.Methods: A total of 63 PH patients were retrospectively studied. Patients were classified into high RAFI group and low RAFI group based on the median of RAFI. Echocardiography parameters of right heart dimension, RV overload, RV function and RA strain were assessed. Patients’ data of clinical characteristics were documented.Results: Elevated pulmonary arterial pressure, dilated RV dimension, RV overload and worsen cardiac function were observed in low RAFI group (P < 0.05). RAFI was significantly correlated with clinical and echocardiographic indices of pulmonary arterial pressure, pulmonary vascular resistance, RV dimension, RV overload and cardiac function (P < 0.05). In multivariable binary logistic regression analysis, RAFI independently predicted World Heart Organization functional class (WHO FC) III or IV (odds ratio = 0.847; 95% confidence interval, 0.722-0.994; P = 0.041). RAFI < 9.7 was the best cutoff to identify patients with WHO FC III or IV, with sensitivity of 70% and specificity of 79% (area under the curve = 0.777; 95% confidence interval, 0.660-0.894).Conclusions: RAFI provided an easy and valid alternative approach to evaluating RA function. RAFI showed correlation with most clinical and echocardiographic indices of right heart. RAFI was the independent determinant of WHO FC III or IV implying clinical deterioration.
Evidence of communication between heat-stressed and unheat-stressed Caenorhabditis elegans via volatile stress signal
Authors: chen Liangwen , wang Yun , Zhou Xiuhong , Wang Ting , Zhan Huimin , Wu Fei , Li Haolan , Bian Po , Xie Zhongwen 
Published: April 2022

Abstract
Our research group has recently described that radiation-induced airborne stress signals can be communicated between Caenorhabditis elegans (C. elegans). This paper addresses the question of whether heat stress can also induce emission of airborne stress signal to alert neighboring C. elegans and elicit their subsequent stress response. Here, we report that heat-stressed C. elegans produces volatile stress signal(s) that trigger an increase in radiation resistance in neighboring unheat-stressed C. elegans. When several loss-of-function mutations affecting the thermosensory neuron (AFD), heat shock factor-1 (HSF-1), and small heat-shock proteins (HSPs) were used as the heat-stressed C. elegans, we found that the production of the volatile stress signal(s) were blocked, demonstrating the heat shock response as a role in controlling the production of the volatile stress signal(s). It can be found that the mutations affecting DNA damage response (DDR) could inhibit the increasing of radiation resistance in neighboring unheat-stressed C. elegans having received the volatile stress signal(s), which indicate that the DDR might contribute to RAR induction by the volatile stress signal(s). Together, this study demonstrates that heat-stressed nematodes could communicate with unheat-stressed nematodes via volatile stress signal. In addition, the regulating pattern of signal production and action are preliminarily clarified.
Different host plants alter structure, diversity, and function of gut bacterial communities in larval instars of Spodoptera frugiperda
Authors: Wang Yanping , Yi Chunyan , Chen Xingyu , Guo Jingwei , Liu Changhua , Zhang Cuicui , Chen Qingdong , Chen Song , Liu Hongling , Liu Xu 
Published: April 2022

Abstract
Insect gut microbes have important roles in host feeding, digestion, immunity, and growth and development. The fall armyworm, Spodoptera frugiperda, is a major migratory agricultural pest worldwide, effects of host plants on its communities of gut bacteria remain to be investigated. Therefore, differences in gut bacterial communities were examined in S. frugiperda 5th and 6th instar larvae fed leaves of different host plants (corn, sorghum, highland barley, citrus). Metagenomic DNA was extracted from larval intestines, and abundance and diversity of gut bacteria were determined using 16S rDNA full-length amplification and sequencing. Highest richness and diversity of gut bacteria were in corn-fed 5th instar larvae; whereas in 6th instar larvae, richness and diversity were higher when larvae were fed other crops. Firmicutes and Proteobacteria were dominant phyla in gut bacterial communities of 5th and 6th instar larvae. According to LEfSe analysis, host plant had important effects on structure of gut bacterial communities in S. frugiperda. In an analysis using PICRUSt2 software, most predicted functional categories were associated with metabolism. Thus, the plant species attacked by S. frugiperda larvae affects their gut bacterial communities, and such changes are likely important in adaptation to a host plant.
Water decontamination in terms of Hg (II) over thiol immobilized magnesium ferrite – Gum Arabic biosorbent: Response surface optimization, kinetic, isotherm and comparing study
Authors: Nowroozi Mostafa , Alijani Hassan , Beyki Mostafa Hossein , yadaei Hassan , Shemirani Farzaneh 
Published: April 2022

Abstract
Mercury thrown even at a low concentrations in water resources causes a severe threat to ecosystem hence the presented work describes a low cost and environmentally friendly clean up platform for decontamination of water in terms of mercury ions. For this purpose MgFe2O4 – Gum Arabic composite was prepared with a simple ultrasound assisted precipitation route and further modified with L-cysteine as a thiol resource to improve its adsorption characteristic. The structure of biosorbent was characterized with XRD, FESEM, VSM, EDX, and BET techniques. Effective parameters on mercury adsorption were optimized with response surface methodology (RSM) using Box-Behnken design (BBD). Maximum removal efficiency was obtained at pH of 5, contact time of 15 min and adsorbent dosage of 19 mg by magnetic GA. After thiol functionalization optimum variables changed to pH of 2, time of 15 min and dosage of 5 mg. Isotherm study indicated that mercury biosorption onto the magnetic Gum Arabic and thiol immobilized sorbent followed Langmuir and Freundlich model with adsorption capacity of 96 and 250 mg g-1, respectively. Results for kinetic study revealed that mercury adsorption followed pseudo – second order model. To study the ability of biosorbent as a reusable compound a mixture of HCl (0.5 mol L-1) and thiourea (2%) was employed to release the adsorbed ions from the sorbent surface moreover, it showed 90% removal efficiency after three cycles of sorption and desorption which confirmed the presented composite is a reusable biosorbent.
Diagnostic value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study
Authors: Song Jieqiong , Yao Yao , Lin Shilong , He Yizhou , Zhu Duming , Zhong Ming 
Published: April 2022

Abstract
Background
Currently, there is no formal diagnostic criterion for sepsis-induced cardiomyopathy (SICM). The classic approach has been to use left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) to define SICM. In this regard, tissue motion annular displacement (TMAD) is a novel speckle tracking indicator to quickly assess LV longitudinal systolic function. This study aimed to evaluate the feasibility and application value of TMAD in the diagnosis of SICM in septic patients.
Methods
We conducted a single-center retrospective observational study in sepsis or septic shock patients who underwent echocardiography examination within the first 24h after admission. Basic clinical information and conventional echocardiographic data were collected. Based on speckle tracking echocardiography (STE), GLS and TMAD were respectively performed offline. The correlations between TMAD and other LV systolic function parameters, as well as the diagnostic value of TMAD for SICM, were assessed. Data of 28d and in-hospital mortality were compared between SICM and non-SICM patients.
Results
A total of 143 patients were enrolled in this study. The incidence of SICM according to GLS or TMAD criteria was significantly higher than that according to LVEF criteria (32.9% vs. 18.2%, p = 0.006; 38.5% vs. 18.2%, p < 0.001). The 28d and in-hospital mortality of SICM patients were significantly higher than the non-SICM patients according to any of the diagnostic criteria (all p < 0.05). Significant correlations between TMAD and other LV systolic function echocardiographic parameters, including LVEF, GLS, mitral annular plane systolic excursion (MAPSE), and maximal lateral systolic mitral annular tissue velocity (MA Smax), were detected (all p < 0.001). According to the AUROC value, TMADMid had an excellent diagnostic value for SICM (AUROC > 0.9). Compared with LVEF and GLS, TMAD had the highest intra-observer and inter-observer reliability. The mean time for off-line analyses with TMAD was significantly shorter than that with LVEF or GLS (p < 0.05).
Conclusion
STE-based TMAD is a feasible, reliable, and time-saving option to assess the LV systolic function. Overall, this approach shows an excellent diagnostic value for SICM in septic patients.
KRCC1, a novel modulator of the DNA damage response
Authors: Neizer-Ashun Fiifi , Dwivedi Shailendra , Dey Anindya , Thavathiru Elangovan , Berry William , Lees-Miller Susan , Mukherjee Priyabrata , Bhattacharya Resham 
Published: April 2022

Abstract
The lysine rich coiled-coil 1 (KRCC1) protein is overexpressed in multiple malignancies including ovarian cancer and overexpression correlates with poor overall survival. Despite a potential role in cancer progression, the biology of KRCC1 remains elusive. Here we characterize the biology of KRCC1 and define its role in the DNA damage response and in cell cycle progression. We demonstrate that KRCC1 associates with the checkpoint kinase 1 (CHK1) upon DNA damage and regulates the CHK1-mediated checkpoint. KRCC1 facilitates RAD51 recombinase (RAD51) foci formation and augments homologous recombination repair. Furthermore, KRCC1 is required for proper S-phase progression and subsequent mitotic entry. Our findings uncover a novel component of the DNA damage response and a potential link between cell cycle, associated damage response, and DNA repair.
Myometrial Oxidative Stress Drives MED12 Mutations for Leiomyoma development
Authors: Li Yinuo , Xu Xiuhua , Asif Huma , Feng Yue , Kohrn Brendan F. , Kennedy Scott R. , Kim J Julie , Wei Jian-Jun 
Published: April 2022

Abstract
Background

More than 70% of leiomyomas (LM) harbor MED12 mutations, primarily in exon 2 at c.130-131(GG). The cause of MED12 mutations in myometrial cells remains largely unknown. We hypothesized that increased ROS promotes MED12 mutations in myometrial cells through the oxidation of guanine nucleotides followed by misrepair.

Methods

Genomic oxidative burden (8-OHdG) was evaluated in vitro and in vivo by immunohistochemistry. MED12 mutations were examined by Sanger sequencing and deep sequencing. Transcriptome examined by RNA-seq was performed in myometrium with and without LM, in primary myometrial cells treated with ROS. 8-OHdG mediated misrepair was analyzed by CRISPR/Cas9.

Results

Uteri with high LM burden had a significantly higher rate of MED12 mutations than uteri with low LM burden. Compelling data suggest that the uterus normally produces reactive oxidative species (ROS) in response to stress, and ROS levels in LM are elevated due to metabolic defects. We demonstrated that genomic oxidized guanine (8-OHdG) was found at a significantly higher level in the myometrium of uteri that had multiple LM compared to myometrium without LM. Transcriptome and pathway analyses detected ROS stress in myometrium with LM. Targeted replacement of guanine with 8-OHdG at MED12 c.130 by CRISPR/Cas9 significantly increased the misrepair of G>T. Exposure of primary myometrial cells to oxidative stress in vitro increased misrepair/mutations as detected by duplex sequencing.

Conclusions

Together, our data identified a clear connection between increased myometrial oxidative stress and a high rate of MED12 mutations that may underlie the risk of LM development and severity in women of reproductive age.
Synthesis of porous hollow spheres Co@TiO 2-x -carbon composites for highly efficient lithium-ion batteries
Authors: Liang Chunyong , Huang Zhongliang , Chen Lu , Wang Hongshui , Yang Tai , Liu Ning , Liao Tingdi , Wang Feng 
Published: April 2022

Abstract
The hollow TiO2 anode material has received great attention for next-generation LIBs because of its excellent stability, environmental friendly, and low volume change during lithiation/delithiation. Nevertheless, the current anatase TiO2 anode materials are unable to be energy storage system owing to low lithium ion diffusivity and poor reversible theoretical capacities. The introduction of defects has been turned out to be a significant and effective method to improve electronic conductivity, especially oxygen vacancies (OVs). In this paper, a facile hydrothermal reaction and subsequent chemical vapor deposition method were successfully used to fabricate Co@TiO2-x-carbon hollow nanospheres. These results suggest that the synthesized product exhibits good rate performance and superior cycling stability.
Improving and further analysis of eCPDP (EarlyCross-Project Defect Prediction)
Authors: Kwon Sunjae , Ryu Duksan , Baik Jongmoon 
Published: April 2022

Abstract
Abstract Context Cross-project Defect Prediction (CPDP) utilizes other finished project (i.e., source project) data to predict defects of the current working project. Transfer Learning (TL) has been mainly applied at CPDP to improve prediction performance by alleviating the data distribution discrepancy between different projects. However, existing TL-based CPDP techniques are not applicable at the unit testing phase since they require the entire historical target project data. As a result, they lose the chance to increase the product’s reliability in the early phase by applying the prediction results.Objective To increase the product’s reliability in the early phase by proposing a novel TL-based CPDP technique applicable at the unit testing phase (i.e., eCPDP).Method We utilize Singular Value Decomposition (SVD) that only requires source project data for TL. Result eCPDP shows similar or better performance than the 5 state-of-the- art TL-based CPDP techniques on 9 different performance metrics over 24 projects.Conclusion 1) We show that eCPDP is an applicable CPDP model at the unit testing phase. 2) It can help practitioners find and fix defects in an earlier phase than other TL-based CPDP techniques.