bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of non-restrictive cor triatriatum sinister during concomitant cardiac surgery
Authors: Di Bacco Lorenzo , D’Alonzo Michele , Repossini Alberto , Zanin Francesca , Muneretto Claudio , Benussi Stefano 
Published: June 2022

Abstract
Background
Cor triatriatum is a rare congenital heart disease representing the 0.4% of all congenital cardiac anomalies. To date, no specific genetic alteration has been associated to cor triatriatum. The left-sided presentation (cor triatriatum sinister (CTS)) generally consists in a fibromuscular membrane that divides the left atrium into two chambers, therefore generating a varying grade of flow obstruction depending on the shape, location, and membrane fenestration size. Cor triatriatum sinister can be isolated or associated to other congenital heart defects such as ostium secundum atrial septal defect, patent foramen ovale or abnormal pulmonary veins drainage.

Case presentation
Our case is a 63-year-old woman who was diagnosed with a non-restrictive membrane during a hospitalization for acute heart failure. In the following 6 months, she started to become symptomatic. However, the onset of symptoms was more likely related to mitral valve regurgitation worsening and previously unknown coronary artery disease, rather than to CTS. She underwent bi-atrial surgical ablation (Cox Maze IV procedure) for atrial fibrillation (AF), surgical resection of interatrial membrane with mitral annuloplasty, and myocardial revascularization.

Conclusion
The onset and severity of symptoms in patients with CTS mostly depend on membrane fenestration size, grade of stenosis generated and pulmonary veins drainage site. However, some cases may remain asymptomatic until adulthood; the degree of pulmonary hypertension and congestive heart failure is determined by the presence of additional cardiac anomalies and the fibromuscular membrane fenestration. In some cases, CTS may remain asymptomatic, thus the diagnosis can be incidental.
Mental health and well-being during the second wave of COVID-19: longitudinal analyses of the UK COVID-19 Mental Health and Wellbeing study (UK COVID-MH)
Authors: Wetherall Karen , Cleare Seonaid , McClelland Heather , Melson Ambrose J. , Niedzwiedz Claire L. , O'Carroll Ronan E. , O'Connor Daryl B. , Platt Steve , Scowcroft Elizabeth , Watson Billy , Zortea Tiago , Ferguson Eamonn , Robb Kathryn A. , O'Connor Rory C. 
Published: June 2022

BackgroundWaves 1 to 3 (March 2020 to May 2020) of the UK COVID-19 Mental Health and Wellbeing study suggested an improvement in some indicators of mental health across the first 6 weeks of the UK lockdown; however, suicidal ideation increased.AimsTo report the prevalence of mental health and well-being of adults in the UK from March/April 2020 to February 2021.MethodQuota sampling was employed at wave 1 (March/April 2020), and online surveys were conducted at seven time points. Primary analyses cover waves 4 (May/June 2020), 5 (July/August 2020), 6 (October 2020) and 7 (February 2021), including a period of increased restrictions in the UK. Mental health indicators were suicidal ideation, self-harm, suicide attempt, depression, anxiety, defeat, entrapment, loneliness and well-being.ResultsA total of 2691 (87.5% of wave 1) individuals participated in at least one survey between waves 4 and 7. Depressive symptoms and loneliness increased from October 2020 to February 2021. Defeat and entrapment increased from July/August 2020 to October 2020, and remained elevated in February 2021. Well-being decreased from July/August 2020 to October 2020. Anxiety symptoms and suicidal ideation did not change. Young adults, women, those who were socially disadvantaged and those with a pre-existing mental health condition reported worse mental health.ConclusionsThe mental health and well-being of the UK population deteriorated from July/August 2020 to October 2020 and February 2021, which coincided with the second wave of COVID-19. Suicidal thoughts did not decrease significantly, suggesting a need for continued vigilance as we recover from the pandemic.
Condensation properties of stress granules and processing bodies are compromised in myotonic dystrophy type 1
Authors: Gulyurtlu Selma , Magon Monika S. , Guest Patrick , Papavasiliou Panagiotis P. , Morrison Kim D. , Prescott Alan R. , Sleeman Judith E. 
Published: June 2022

ABSTRACT
RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases. Myotonic dystrophy type 1 (DM1) is a multi-systemic trinucleotide repeat disorder resulting from an expansion of nucleotides CTG (CTGexp) in the DNA encoding DM1 protein kinase (DMPK). The cellular hallmark of DM1 is the formation of nuclear foci that contain expanded DMPK RNA (CUGexp) (with thymine instead of uracil). We report here the deregulation of stress granules (SGs) and processing bodies (P-bodies), two cytoplasmic structures key for mRNA regulation, in cell culture models of DM1. Alterations to the rates of formation and dispersal of SGs suggest an altered ability of cells to respond to stress associated with DM1, while changes to the structure and dynamics of SGs and P-bodies suggest that a widespread alteration to the biophysical properties of cellular structures is a consequence of the presence of CUGexp RNA.
The mechanical and morphological properties of systemic and pulmonary arteries differ in the Madagascar ground boa, a snake without ventricular pressure separation
Authors: van Soldt Benjamin J. , Wang Tobias , Filogonio Renato , Danielsen Carl Christian 
Published: June 2022

ABSTRACT
The walls of the mammalian aorta and pulmonary artery are characterized by diverging morphologies and mechanical properties, which have been correlated with high systemic and low pulmonary blood pressure, as a result of intraventricular pressure separation. However, the relationship between intraventricular pressure separation and diverging aortic and pulmonary artery wall morphologies and mechanical characteristics is not understood. The snake cardiovascular system poses a unique model for the study of this relationship, as representatives both with and without intraventricular pressure separation exist. In this study, we performed uniaxial tensile testing on vessel samples taken from the aortas and pulmonary arteries of the Madagascar ground boa, Acrantophis madagascariensis, a species without intraventricular pressure separation. We then compared these morphological and mechanical characteristics with samples from the ball python, Python regius, and the yellow anaconda, Eunectes notaeus – species with and without intraventricular pressure separation, respectively. Our data suggest that although the aortas and pulmonary arteries of A. madagascariensis respond similarly to the same intramural blood pressure, they diverge in morphology, and that this attribute extends to E. notaeus. In contrast, P. regius aortas and pulmonary arteries diverge both morphologically and in terms of their mechanical properties. Our data indicate that intraventricular pressure separation cannot fully explain diverging aortic and pulmonary artery morphologies. Following the law of Laplace, we propose that pulmonary arteries of small luminal diameter represent a mechanism to protect the fragile pulmonary vasculature by reducing the blood volume that passes through, to which genetic factors may contribute more strongly than physiological parameters.
Effectiveness of balance training on pain and functional outcomes in knee osteoarthritis: A systematic review and meta-analysis
Authors: Prabhakar Ashish John , R Shruthi , Thomas Dias Tina , Nayak Pradeepa , Joshua Abraham M. , Prabhu Srikanth , Kamat Yogeesh Dattakumar 
Published: June 2022

Background: Knee osteoarthritis (OA) is a musculoskeletal disorder that causes pain and increasing loss of function, resulting in reduced proprioceptive accuracy and balance. Therefore, the goal of this systematic review and meta-analysis is to evaluate the effectiveness of balance training on pain and functional outcomes in knee OA. Methods: “PubMed”, “Scopus”, “Web of Science”, “Cochrane”, and “Physiotherapy Evidence Database” were searched for studies conducted between January 2000 and December 2021. Randomized controlled trials (RCTs) that investigated the effectiveness of balance training in knee OA, as well as its effects on pain and functional outcome measures, were included. Conference abstracts, case reports, observational studies, and clinical commentaries were not included. Meta-analysis was conducted for the common outcomes, i.e., Visual Analog Scale (VAS), The Timed Up and Go (TUG), Western Ontario and McMaster Universities Arthritis Index (WOMAC). The PEDro scale was used to determine the quality of the included studies. Results: This review includes 22 RCTs of which 17 articles were included for meta-analysis. The included articles had 1456 participants. The meta-analysis showed improvement in the VAS scores in the experimental group compared to the control group [I2 = 92%; mean difference= -0.79; 95% CI= -1.59 to 0.01; p<0.05] and for the WOMAC scores the heterogeneity (I2) was 81% with a mean difference of -0.02 [95% CI= -0.44 to 0.40; p<0.0001]. The TUG score was analyzed, the I2 was 95% with a mean difference of -1.71 [95% CI= -3.09 to -0.33; p<0.0001] for the intervention against the control group. Conclusions: Balance training significantly reduced knee pain and improved functional outcomes measured with TUG. However, there was no difference observed in WOMAC. Although due to the heterogeneity of the included articles the treatment impact may be overestimated. Registration: The current systematic review was registered in PROSPERO on 7th October 2021 (registration number CRD42021276674).
Thermal comfort optimization through bioclimatic design in Mediterranean cities
Authors: Hany Nermine , Alaa Hala 
Published: June 2022

Background: Bioclimatic design is an approach based on local climate which improves thermal qualities and indoor comfort. Buildings follow this process to minimize negative effects on the environment. However, this approach is still not suitable in developed countries. This study aims to investigate Mediterranean local bioclimatic strategies’ impact on thermal comfort efficiency in housing, by examining architectural elements and treatments. Methods: We adopted a descriptive, analytical, and comparative methodology, complemented with a software simulation, within a qualitative and quantitative approach. Investigation and methodological tools were based on technical information including plans, elevations, photos, and documentation. The approach consisted of multiple stages: a literature review interpreting the concept of bioclimatic design, as well as thermal comfort variables and common Mediterranean building features. Moreover, the paper showcases three examples of successful Mediterranean passive houses. Furthermore, the paper presents a case- studyhouse in Alex West, Alexandria, designed in the Mediterranean Revival style. Results: The results showed that the most influencing building features on thermal comfort were the low-pitched roofs and the top chimney, which achieved 12.6% and 5% improvement in the summer and 13% and 6.8% in winter, respectively. The pergola and porch elements barely had an effect when placed on the northern façade. However, on the southern façade, a positive contribution in the summer by 1.4% and 3.4% respectively were reported, but a slight negative impact in winter by 0.5% and 2% respectively. Conclusions: We examined the impact of common Mediterranean building features , and compared thermal comfort results between case-study houses. Features focusing on passive design for cooling rather than heating, allowing wind flow for maximized natural ventilation, using ventilated pitched roof spaces, using sun shading elements in the proper facades and angles, help passive thermal regulation. The study proposes recommendations for optimizing thermal comfort in residential buildings in Alexandria, Egypt.
A multi-stakeholder participatory pilot study of the data demands of the future Ethiopian dairy sector
Authors: Perry Brian D. , Aklilu Gebreyes Yacob , Hailemariam Solomon , Legese Getachew , Smyth Karen , Peters Andrew R. , Allan Fiona K. , Tegegne Azage 
Published: June 2022

Background: This paper describes a pilot study undertaken in 2018, to determine the key data needs of each of the different Ethiopian dairy sector stakeholder groups. The study aimed to characterise the emerging trends of dairy product production, processing, retailing and consumption in Ethiopia, and to identify and characterise current and future data needs of different stakeholders. Methods: The study undertook a mapping of the interactions between different stakeholders in the dairy sector, and an interactive evaluation of the institutional data repository and access options. Focus group discussions and interviews were held in three regions of the country prior to a two-day workshop in the capital Addis Ababa. Data needs were characterised by type, availability, format, level of detail, methods of dissemination, uptake and use, and the institutional arrangement, including the different roles of public and private sectors in decision making processes. Results: The study highlighted the main data needs and identified several broader institutional issues constraining the further development of the Ethiopian dairy sector. The stakeholder groups endorsed the reactivation of a national dairy board, independent of government but closely incorporating government, and with the buy-in and membership of private sector enterprises, including producers, processers, service providers and consumers, to provide clearer facilitative leadership on the dairy industry. Conclusions: The study workshop provided a timely discussion between diverse stakeholders, including government, and several potential organisations were suggested to host and manage a national dairy database. Importantly, the reactivation of a national dairy board was strongly endorsed. It was recommended that stakeholder links be established, sector-specific data needs be elevated to higher detail, and a national roll out of herd-specific data recording schemes was called for, to allow for effective evidence-based policies and decision making.
Acute pain assessments and records: a pilot study of digital transformation
Authors: Roberts Luke , Lanes Sadie , Kyte Jemma , Grady Joanne , Holdship Jonathan , Carey Caroline , Cooney Katrina , Ramessur Suneil 
Published: June 2022

Background: Pain is a leading cause of disability worldwide. Pain assessments are an essential part of evidence-based care and management. Among comparable care providers, there is variation in how nurses document assessments as well as the content in them, and there is a notable associated administrative burden. Aims: This study evaluated the impact and significance of a new, structured, digitised pain assessment form from quality, safety and efficiency standpoints. Methods: Samples of pain assessments were examined at three consecutive stages: first, the pre-existing form was used, then the new structured form was introduced and, finally, the structured form was taken away and nurses went back to completing the original form. Assessments were scored by two clinical analysts against 18 clinically defined pain-related characteristics and factors. The time taken to extract and interpret the assessments was also recorded. Statistically significant changes were assessed using Welch's t-tests and Fisher's exact tests. Findings: There was a significant improvement in data quality using the new structured form compared with the pre-existing template, including an increase in the capture of five safety-related variables. Less time was needed to extract and interpret data with the new form. Conclusion: Intelligent structured forms are highly effective for documenting pain assessments, and offer notable benefits in quality, safety, and efficiency.
Nurses' symptom management and views on death and caring for heart failure and chronic obstructive pulmonary disease
Authors: Matsui Miho 
Published: June 2022

Background: The number of older adult patients in Japan is increasing and symptom management is needed not only for cancer patients, but also non-cancer patients. Aims: This study investigated nurses' symptom management and their views on death and caring for heart failure (HF) and chronic obstructive pulmonary disease (COPD). Methods: A cross-sectional survey using a questionnaire was conducted. Survey items were implementation of assessment and non-pharmacological interventions for 14 symptoms at the end-of-life stage, participation in palliative care training courses and attitude toward death and caring, as assessed by the Frommelt attitude toward care of the dying (FATCOD) Scale. Results: A total of 266 (78.5%) nurses responded. More than 90% implemented symptom assessment of dyspnea and cough for both HF and COPD. The mean FATCOD score was 114.7, participation in on-the-job palliative care training courses (p<0.01), and difficulty with near-death issues (p<0.01) were significantly associated with the FATCOD. Conclusion: These results suggest that nurses assessed the major symptoms of HF and COPD. Training courses are important to promote palliative care for non-cancer patients.
Strengths, weaknesses, opportunities and threats analysis of being an oncology nurse: a Turkish oncology nurses' perspective
Authors: Kutlutürkan Sevinç , Kırca Kamile 
Published: June 2022

Background:Oncology nurses play a key role in providing high-quality treatment and care to cancer patients.Aim:The aim of this study was to determine oncology nurses' views of the strengths, weaknesses, opportunities, and threats to oncology nurses.Methods:This descriptive pilot study was conducted online between December 2018 and January 2019. The study population consisted of 845 nurses who were members of the Oncology Nursing Association of Turkey. The sample consisted of 80 oncology nurses. Data were collected using an online survey. Participants' responses were grouped and evaluated. Data were analysed using numbers and percentages.Results:The mean age of participants was 34.34±8.23 years. A total of 48 participants (60.5%) were university hospital nurses, and 63 (79.5%) were medical oncology nurses. Participants had 8.06±6.72 (mininum 1 and maximum 22) years of work experience as oncology nurses. For participants, the central strengths of oncology nurses were speed, self-confidence, neatness, composure, patience, compassion or attention (72.4%); psychosocial support (64.5%); and training and consultancy (58.1%). For participants, the first three weaknesses of oncology nurses were over-sentimentality, helplessness or burnout (54.2%); working conditions (50%); and limited knowledge (47.3%). For participants, the first three opportunities of oncology nursing were attending organisations on oncology nursing (62.4%), education and research (50%), and developing patience, strength, empathy, and critical thinking skills (48.6%). For participants, the first three threats to oncology nurses were employee safety issues (76.6%), psychosocial problems (65%) and physical problems (48.8%).Conclusion:Weaknesses and threats should be eliminated for the development of oncology nursing in the light of its strengths and opportunities.
Statewide evaluation of COVID-19 vaccine hesitancy in Rhode Island
Authors: Rogers Brooke G. , Tao Jun , Almonte Alexi , Toma Emily , Nagel Katherine , Fain Robert , Napoleon Siena C. , Maynard Michaela A. , Murphy Matthew , Sarkar Indra Neil , Chan Philip A. 
Published: June 2022

Background
Vaccines are effective in preventing Coronavirus Disease 2019 (COVID-19). Vaccine hesitancy defined as delay of acceptance or refusal of the vaccine is a major barrier to effective implementation.

Methods
Participants were recruited statewide through an English and Spanish social media marketing campaign conducted by a local news station during a one-month period as vaccines were becoming available in Rhode Island (from December 21, 2020 to January 22, 2021). Participants completed an online survey about COVID-19 vaccines and vaccine hesitancy with constructs and items adopted from the Health Belief Model.

Results
A total of 2,007 individuals completed the survey. Eight percent (n = 161) reported vaccine hesitancy. The sample had a median age of 58 years (interquartile range [IQR]: 45, 67), were majority female (78%), White (96%), Non-Hispanic (94%), employed (58%), and reported an annual individual income of $50,000 (59%). COVID-19 vaccine hesitancy was associated with attitudes and behaviors related to COVID-19. A one unit increase in concern about COVID-19 was associated with a 69% (Adjusted Odds Ratio: 0.31, 95% CI: 0.26–0.37) decrease in vaccine hesitancy. A one-level increase in the likelihood of getting influenza vaccine was associated with a 55% (AOR: 0.45 95% CI: 0.41–0.50) decrease in vaccine hesitancy.

Conclusions
COVID-19 vaccine hesitancy was relatively low in a state-wide survey in Rhode Island. Future research is needed to better understand and tailor messaging related to vaccine hesitancy.
The discrepancies between clinical and histopathological diagnoses of cardiomyopathies in patients with stage D heart failure undergoing heart transplantation
Authors: Lertsuttimetta Thana , Tumkosit Monravee , Kaveevorayan Peerapat , Chantranuwatana Poonchavist , Theerasuwipakorn Nonthikorn , Chattranukulchai Pairoj , Puwanant Sarinya 
Published: June 2022

Background
This study aimed to determine the etiology of stage-D heart failure (HF) and the prevalence and prognosis of misdiagnosed cardiomyopathy in patients undergoing heart transplantation.

Methods and results
We retrospectively reviewed 127 consecutive patients (mean age, 42 years; 90 [71%], male) from February 1994 to September 2021 admitted for heart transplant in our tertiary center. Pre-transplant clinical diagnosis was compared with post-transplant pathological diagnosis. The most common misdiagnosed cardiomyopathy was nonischemic cardiomyopathy accounting for 6% (n = 8) of all patients. Histopathological examination of explanted hearts in misdiagnosed patients revealed 2 arrhythmogenic cardiomyopathy, 2 sarcoidosis, 1 hypertrophic cardiomyopathy, 1 hypersensitivity myocarditis, 1 noncompacted cardiomyopathy, and 1 ischemic cardiomyopathy. Pre-transplant cardiac MRI and endomyocardial biopsy (EMB) were performed in 33 (26%) and 6 (5%) patients, respectively, with both performed in 3 (3% of patients). None of the patients undergoing both cardiac tests were misdiagnosed. During the 5-years follow-up period, 2 (25%) and 44 (37%) patients with and without pretransplant misdiagnosed cardiomyopathy died. There was no difference in survival rate between the groups (hazard ratio: 0.52; 95% CI:0.11–2.93; P = 0.314).

Conclusions
The prevalence of misdiagnosed cardiomyopathy was 6% of patients with stage-D HF undergoing heart transplantation, the misdiagnosis mostly occurred in nonischemic/dilated cardiomyopathy. An accurate diagnosis of newly detected cardiomyopathy gives an opportunity for potentially reversing cardiomyopathy, including sarcoidosis or myocarditis. This strategy may minimize the need for advanced HF therapy or heart transplantation. With advances in cardiac imaging, improvements in diagnostic accuracy of the etiology of HF can improve targeting of treatment.