bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender differences in diagnostic tools, medication, time to medication, and nonmotor symptoms in Parkinsonian patients
Authors: Skogar Örjan , Nilsson Mats , Lökk Johan 
Published: December 2022

BACKGROUND:
Swedish National Quality Registers (NQRs) play an important role in collecting large amounts of diagnosis-specific data, symptoms, and treatments. The subset of data, Parkinson's Registry, has been in use for more than 20 years and represents all counties and hospitals in Sweden where neurological care is provided.

OBJECTIVE:
To study the differences between genders regarding diagnostic tools, pharmacological interventions, and self-reported symptoms in patients with symptoms originating from basal ganglia disease, either idiopathic or secondary Parkinsonism (PD).

METHODS:
PD-diagnosed patients from a mix of urban and rural locations were chosen from the NQR and sorted by gender. Self-reported, first-experienced PD-related symptoms defined the debut point of PD.

RESULTS:
In all, data from 1,217 patients were analyzed: 502 (41%) females/715 (59%) males. A total of 493 imaging investigations were performed, where of 239 (48% females/52% males) had a CT scan performed, 120 (24% females/29% males) had a dopamine transporter scans, and 134 (23% females/26% males) had a magnetic resonance imaging performed (Fisher's exact test, P = 0.19). The average time in years from symptom onset to start of first treatment, and from first to second added treatment was 2;7/2;9 (females) and 5;1/5;2 (males). Nonmotor symptoms were more prominent among males, especially in memory and gastrointestinal domains, including drooling and obstipation. Significantly more sexual problems were reported from males; 26% versus 7% (Fisher's exact test, P < 0.0001).

CONCLUSIONS:
Differences between genders were identified in this study. Sexual problems and cognitive decline were more frequent among males. More advanced diagnostic imaging techniques were performed among males. The time point for a second added medication was earlier for males than females.
Unaffected ex vivo clotting cascade by experimental hemostatic nanoparticles when introduced in the presence of recombinant tissue plasminogen activator
Authors: Beyer Margaret , France John , Nagaraja Tavarekere N. , Lavik Erin B. , Knight Robert A. , Lewandowski Christopher A. , Miller Joseph B. 
Published: December 2022

CONTEXT:
Hemostatic nanoparticles (hNPs) have shown efficacy in decreasing intracerebral hemorrhage (ICH) in animal models and are suggested to be of use to counter tissue plasminogen activator (tPA)-induced acute ICH.

AIMS:
The objective of this study was to test the ability of an hNP preparation to alter the clotting properties of blood exposed to tPA ex vivo.

MATERIALS AND METHODS:
Fresh blood samples were obtained from normal male Sprague-Dawley rats (~300 g; n = 6) and prepared for coagulation assays by thromboelastography (TEG) methods. Samples were untreated, exposed to tPA, or exposed to tPA and then to hNP. TEG parameters included reaction time (R, time in minutes elapsed from test initiation to initial fibrin formation), coagulation time (K, time in minutes from R until initial clot formation), angle (α, a measure in degrees of the rate of clot formation), maximum amplitude (MA, the point when the clot reaches its MA in mm), lysis at 30 min after MA (LY30, %), and clot strength (G, dynes/cm2), an index of clot strength.

STATISTICAL ANALYSIS USED:
Kruskal–Wallis test was employed to compare TEG parameters measured for untreated control samples versus those exposed to tPA and to compare tPA-exposed samples to samples treated with tPA + hNPs. Significances were inferred at P ≤ 0.05.

RESULTS:
Compared to untreated samples, tPA-treated samples showed a trend toward decreased angle and G suggesting potentially clot formation rate and clot strength. The addition of hNP did not affect any of these or other measured indices.

CONCLUSIONS:
The data demonstrated no hemostatic effects when the hNP was used in the presence of tPA. The lack of change in any of the TEG parameters measured in the present study may indicate limitations of the hNPs to reverse the thrombolytic cascade initiated by tPA.
Assessment of Relationship between Anthropometric Measurements and Reproductive Hormonal Profiles, Among Females of Childbearing Age at a Tertiary Health Facility in Nigeria
Authors: Oladosu Waliu O. , Alayo Adewale M. , Ahmed Aminat O. , Jimoh Olanrewaju S. , Olarinoye-Raji Sekinat T. , Egbeyemi Basirat A. , Ajadi Taofeek A. 
Published: December 2022

Background:Increasing prevalence of overweight and obesity has profound impacts on health generally, including the reproductive system. Traditionally, pear body shapes, from narrow waist and wide hip circumferences, have been associated with high fecundability among females. Although this has been scientifically demonstrated by a number of researches only a few of these investigations were conducted with black women in Africa who were of reproductive age.Objectives:The objectives of the study were to compare the mean reproductive hormone levels between the different waist-to-hip ratio (WHR) and body mass index (BMI) categories and also to determine the correlations between the two anthropometric measurements and the reproductive hormones in a black African population.Materials and Methods:It was an analytical cross-sectional study of 180 females of a childbearing age. The WHR and BMI were measured as per standard recommendations. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, day-21 progesterone, and testosterone were assayed.Results:A majority of the research participants were within the age group 21–30 years. Thirty three percent (33%) and 28.9% of participants were overweight and obese, respectively, using BMI compared with 26.7% and 20%, respectively, using WHR. Seventy six point nine percent (76.9%) of participants with an optimal BMI range ovulated with 61.5% having adequate luteal phase support compared with 75% and 54.2%, respectively, using WHR. Day-21 serum progesterone and serum estradiol were significantly negatively correlated with WHR and BMI (P< 0.05). BMI, however, showed a better correlation than WHR (r = -0.535 vs. -0.397;P= 0.001 vs. 0.008, respectively). Gonadotropins were significantly lower among overweight and obese groups for both BMI and WHR (P< 0.05), but only WHR showed moderately positive significant correlation with gonadotropins (LH: r = 0.050 vs. r = 0.215,P= 0.003, respectively; FSH: r = 0.159 vs. r = 0.431,P= 0.001, respectively), same as serum testosterone (r = 0.580 vs. r = 0.611,P= 0.002, respectively).Conclusions:Anthropometric measurements can serve as objective clues to functionality and optimal concentrations of reproductive hormones. Weight control should therefore aid the optimization of reproductive hormones and fertility among females of reproductive age.
Histopathological Evaluation of Benign Soft Tissue Lesions at Nnamdi Azikiwe University Teaching Hospital, Nnewi, South-east Nigeria
Authors: Ezejiofor Ifeoma F. , Olaofe Olaniyi O. , Ezejiofor Ogochukwu I. , Ozor Nnamdi S. , Osonwa Nonyelum C. 
Published: December 2022

Background:
Soft tissue lesions are remarkably diverse and range from inflammatory, self-limited lesions to neoplasm. The diversity of these lesions frequently poses a diagnostic challenge to pathologists and remains a subject of interests. Lack of research on soft tissues in our setting has prompted the need to study them.

Objectives:
The aim of this study was to determine the benign lesions of soft tissues with respect to age, sex, anatomic site, and histologic types. It also aimed to determine the baseline data of benign soft tissue lesions in Nnewi, Nigeria.

Materials and Methods:
This study reviewed all histologically diagnosed benign soft tissue lesions at the Histopathology Department of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria from 2011 to 2019 and classified the tumors using the 2020 WHO Classification of Soft Tissue Tumours.

Results:
A total of 351 cases of soft tissue lesions were diagnosed during the study period, out of which 251 were benign lesions and accounted for 71.5% (251/351) of all soft tissue lesions, whereas 28.5% (100/351) of the cases were malignant. The benign lesions included inflammatory and benign neoplasm, of which neoplasm accounted for the majority of the cases with a frequency of 94.0% (236/251), whereas inflammatory lesions accounted for 5.9% (15/251). The 236 benign soft tissue tumors diagnosed had a male-to-female ratio of 1: 1.4 with a mean age (SD) of 37.5 (19.5) years. The most frequent occurrence of benign tumors was seen in the fourth decade with 52 cases (21.0%), followed by fifth decade with 42 cases (16.7%). Adipocytic tumors were the commonest with a frequency of 54.0% (135/251), followed by peripheral nerve sheath tumors (PNSTs) with 12.4% (31/251) and then vascular and fibroblastic/myofibroblastic tumors with 10.8% (27/251) and 5.6% (14/251), respectively. Lipoma is the most common histologic type of benign soft tissue tumor and the only benign adipocytic tumor. This is followed by hemangioma 9.6% (24/251) and then neurofibroma 7.6% (19/251). Lipoma accounted for 37.09% (135/351) of all soft tissue lesions and the majority of them were seen in the fourth decade, whereas hemagioma and neurofibroma occurred more at the first decade. The most common anatomic distributions of these benign tumors were lower extremities with 23.5% (n = 59/251), followed by trunk 21.1% (n = 53). The major inflammatory lesions were tuberculoid granulomatous inflammation and panniculitis with 2.3% (6/251) of cases each. Others were necrotizing fasciitis (n = 2) and eosinophilic myositis (n = 1).

Conclusion:
Benign soft tissue tumors had a slight female preponderance. Lipoma is the single most common benign soft tissue neoplasm, whereas tuberculosis and panniculitis were the two most common inflammatory soft tissue lesions. Histopathological evaluation of these lesions still stands as a gold standard in their diagnosis.
Development of Nipah virus-specific IgM & IgG ELISA for screening human serum samples
Authors: Shete Anita M. , Jain Rajlaxmi , Mohandas Sreelekshmy , Pardeshi Prachi , Yadav Pragya D. , Gupta Nivedita , Mourya Devendra 
Published: December 2022

Background & objectives:
Nipah virus (NiV) is a zoonotic paramyxovirus that causes fatal encephalitis in humans. Enzyme Linked Immunosorbent Assay (ELISA) is a safe, sensitive, specific, and affordable diagnostic tool that can be used during screening of large-scale epidemiological investigations. Development and evaluation of IgM and IgG ELISA for screening serum samples of NiV suspected cases would also help in planning public health interventions.

Methods:
An IgM capture (MAC) ELISA and an indirect IgG ELISA were developed using NiV antigen to detect IgM and IgG antibodies against NiV in human sera. The sensitivity, specificity, and cross-reactivity of the assays were evaluated using NiV IgM, IgG positive, negative human sera and measles, mumps, rubella, Crimean-Congo haemorrhagic fever, Kyasanur forest disease IgM, IgG positive sera, respectively.

Results:
The developed anti-NiV IgM and IgG ELISAs have shown specificity of 99.28 per cent and sensitivity of 100 per cent compared to reference test from Centers for Disease Control and Prevention, USA. Assays demonstrated negative predictive value of 100 per cent and positive predictive value as 90 and 93.94 per cent for anti-Nipah IgM ELISA and IgG ELISA respectively with test accuracy of 99.33 per cent.

Interpretation & conclusions:
Timely diagnosis of NiV is crucial for the management of cases, which could prevent further spread of infection in the community. IgM ELISA can be used as primary diagnostic tool followed by polymerase chain reaction. These assays have advantages of its applicability during outbreak investigations and surveillance activities at hospital or onsite laboratories with basic biosafety practices.
Homological approximations in persistence theory
Authors: Blanchette Benjamin , Brüstle Thomas , Hanson Eric J. 
Published: December 2022

AbstractWe define a class of invariants, which we call homological invariants, for persistence modules over a finite poset. Informally, a homological invariant is one that respects some homological data and takes values in the free abelian group generated by a finite set of indecomposable modules. We focus in particular on groups generated by “spread modules,” which are sometimes called “interval modules” in the persistence theory literature. We show that both the dimension vector and rank invariant are equivalent to homological invariants taking values in groups generated by spread modules. We also show that the free abelian group generated by the “single-source” spread modules gives rise to a new invariant which is finer than the rank invariant.
Lessons from a Year of COVID-19 in Zambia: Reported Attendance and Mask Wearing at Large Gatherings in Rural Communities
Authors: Juntunen Allison , Kaiser Jeanette L. , Ngoma Thandiwe , Hamer Davidson H. , Fink Günther , Rockers Peter C. , Biemba Godfrey , Scott Nancy A. 
Published: December 2022

ABSTRACT.
Zambia instituted prevention behavior guidelines for social gatherings before the first case of COVID-19 was confirmed on March 18, 2020. Guidelines included nonpharmaceutical interventions (NPIs) including mask wearing, social distancing, and reducing sizes of gatherings. Within a larger cluster randomized trial of community-based parenting groups in four rural districts (three in Southern Province, one in Eastern Province), we collected 5,711 questionnaires from intervention participants between August 2020 and September 2021, during which the country saw two COVID-19 waves. Questionnaires asked about participation and behaviors at community gatherings. Generally, perception of risk of contracting COVID-19 was low for respondents in districts in Southern Province but higher for those in Eastern Province. The highest compliance to mask wearing was reported at clinics (84%) and church services (81%), which were the most frequently attended gatherings. Many funerals were attended by 200 to 300 people, but individuals were 30% less likely to report wearing masks (odds ratio [OR] = 0.71, 95% confidence ratio [CI]: 0.6–0.8) than those attending a clinic visit. After controlling for other variables, the odds of self-reported mask wearing at events were higher in January to March 2021 (adjusted OR = 1.5, 95% CI: 1.3, 1.7) and July and September of 2021 (adjusted OR = 3.0, 95% CI: 2.5–3.5), timepoints that broadly overlay with two COVID-19 peaks observed in Zambia. Results suggest guideline dissemination penetrated the rural areas. However, there is need to optimize the messaging to increase compliance to NPIs at high-risk gatherings, including funerals. The findings from this analysis should be considered as the COVID-19 pandemic continues to evolve.
Children’s Victimization in Turkish Cinema between the 1970s and the 1980s
Authors: Akdağ Menderes , Yetimova Serhat , Eser Hatice Yaren 
Published: December 2022

Between the 1970s and 1980s in Turkey, there were various problems such as rapid urbanization, migration from village to city, economical problems such as embargo and neoliberalism and political violence over the military coups. Our study focuses on the problems experienced by children which lead to child victimization through Turkish movies. In our research, we used deduction and induction methods together. Based on the political and economic developments in the period between 1970 and 1980, we looked at how these dynamics were reflected in the films by thematic analyze method. Here are the themes that we found in the films which are commonly used in relation to children in cities and their urbanization, child marriage, smuggling, political violence and education. In conclusion of the Turkish press and movies and according to the interviews we did with the people who witnessed those periods, the problems related to children manifest themselves quite heavily and negatively. The Turkish society, which is experiencing a rapid urbanization process, has continued the patriarchal, sexist, religious-conservative and statist discourse they brought from the feudal village life in modern cities as well. While this is a problem that the press and cinema criticize with a common approach, it is seen that children are also a part of this process.
Review of the Dictionary “Ecology of Human Existence. Part II. Media Ecology”
Authors: Solomko Dmitry V. 
Published: December 2022

The subject of this review is the second part of the information-military dictionary “Ecology of human existence: media ecology”. The dictionary presents the theme of media ecology or ecology of communications through a number of terms in the aspect of the ecohumanist approach. The authors of the vocabulary articles developed and used it as a new methodology in the study and understanding of the capabilities of modern digital technologies that form the information environment for the existence of a contemporary human. The editors and authors of the vocabulary set a goal of carrying out a philosophical interpretation of the technical and technological conditions of human ‘in-der-Welt-Sein’, in the aspect of information environment (media space), and propose a new, namely, eco-humanistic approach for solving the main problems of the relationship “human – technical and technological world”. The texts of vocabulary articles substantiate the thesis that the capabilities and power of modern digital technologies actualize the need for an eco-humanistic measurement of the relationship “human – technical and technological world”, which does not pre-refuse digital technologies, but means the optimal use of all technological tools, taking into account the detection and preservation of their humanistic potential. The review pays attention to the specifics of the theoretical development of the eco-humanistic approach and its main principles: integrity, optimality, coordination, and eco-systemity. As a result of the analysis the reviewer concludes that the eco-humanistic approach proposed and used by the authors will allow to study and explore the processes and phenomena of contemporary culture in a multidimensional manner, to receive a more accurate interpretation of the ways of human existence and eco-cultural practices that ensure the effect of the staneity of the “ecosystems” in the situations of any intensive technological transformations.
Speedrunner as a Virtual Naturalist
Authors: Kirichenko Vladislav V. 
Published: December 2022

The paper is devoted to the issue of virtual naturalism in computer games, in particular, to such a gaming phenomenon as speedrunning. The author of the study analyzes the essence of speedrunning as a special type of cybersport, as well as a form of counterplay that arose in the minds of gamers around the 1990s. Particular attention is paid to the concept of virtual naturalism, which manifests itself in speed running and can be understood as a form of empirical and materialistic study by gamers of various games and their affordances. The purpose of the work is to establish the features of speedrunning as a research and critical practice, similar to some types of academic analysis, but with different tasks. The central place is occupied by the problem of gamers’ experience during the actualization of speedrunning activity, in which speedrunners study the nature of computer game and call into question game design principles and manipulations, leading to some resistance to artificial prohibitions. This form of confrontation, revealed in different types of speedruns, shows certain nuances of the existence of virtual worlds, which makes it possible to better understand the functioning of computer games as modern cultural artifacts. In result, a conclusion is made about the significance of such borderline phenomena as speedrunning and the need for further study of the counterplay practics.
Struktur Vegetasi Mangrove dan Produksi Serasah Mangrove Sonneratia alba di Telaga Wasti Kabupaten Manokwari, Papua Barat
Authors: Rusianti Christina Recharda , Saleh Fitriyah Irmawati E. , Talakua Selfanie , Alianto Alianto , Mangando Setiawan , Demena Yulianti Elisabet , Manalu Endriano , Eldiester Fredy C. , Rumbino Frits N. Y. , Raharjo Syafrudin 
Published: December 2022

The productivity of mangrove litterfall is the most important part of the transfer of organic materials from mangrove vegetation into the waters and soils. This research was conducted in July-August 2021 in three stations on mangrove ecosystem at Wasti Lake, Manokwari Regency. The purpose of this study was to determine the mangrove vegetation, litterfall production of Sonneratia alba, relation of Diameter at Breast High with litterfall production, and physical chemistry of the environment. The quadrant transect was used to sample mangrove vegetation and the litter trap to measure litter production. The results showed 5 types of mangroves, namely Sonneratia alba, Rhizophora stylosa, Rhizophora apiculata, Bruguiera gymnorrhiza, and Bruguiera sexangua. The highest density values ​​at each station was Sonneratia alba, namely 360 ind/ha, 540 ind/ha and 520 ind/ha with important value indexes are 268.08%, 255.59%, and 247.96%. The total litterfall production of Sonneratia alba during a period of 28 days was 79.19 gr/m². The highest litter contribution components came from leaves (87.6%), twigs (8.1%), and flowers (4.3%). Correlation and regression analysis showed a very strong positive relationship between DBH and litter production. The environmental parameter values ​​for DO ranged from 6.2-8.4 mg/L, water temperature 28.7 – 35.6⁰C, pH ranged from 7.06 – 7.47, salinity 25 – 27.5, substrate pH 6.1 – 6.3, the air temperature is 29-32⁰C, and the humidity is 70-80%.
Efficacy of herbicides in sunflower sowings in the conditions of the western Forest-Steppe of Ukraine
Authors: Hryhoriev V. M. , Fedchuk A. R. 
Published: December 2022

Purpose. Determinе the species composition of weeds and the most efficient system of weed control in sunflower sowings.
Methods. Field, laboratory, mathematical and statistical.
Results. The species composition of spring weeds in sunflower sowings was mainly represented by dicotyledonous species Amaranthus retroflexus L., Chenopodium album L., Galinsoga parviflora Cav., Matricaria inodora L., Thlaspi arvense L., Polygonum convolvulus L., Sinapis arvensis L., Xanthium strumarium L. and cereal weeds Setaria glauca L., Echinochloa cruss-galli L. The efficiency of the use of herbicides Challenge 2.5 l/ha + Harness 1.5 l/ha on the 30th day after application, against the total number of weeds, was 89.7%. Meanwhile, the use of the herbicide Challenge is the application rate of 2.0 l/ha appeared more effective with the efficiency rate of 95.6%. The herbicides, regardless of their application scheme, did not caused thinning of the sowing density; however, plant suppression did occur. This was evidenced by reduced plant height during the anthodium formation and flowering stage compared to control.
Conclusions. The dominant weed species in sunflower crops were Amaranthus retroflexus with the share of 15%, Chenopodium album 8%, Setaria glauca L. 23% and Echinochloa cruss galli 10%. Application of herbicide Challenge 2 l/ha in the 2 to 4 leaf stage of sunflower appeared the most effective as weed control method with the efficiency rate of 92.8%. Herbicides Challenge (2.5 l/ha) + Harness (1.5 l/ha) were milder to crop plants, which ultimately contributed to the formation of sunflower yield of 3.47 t/ha in hybrid ‘NK Condy’ and 3.04 t/ha in hybrid ‘Atilla’.