bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid magma ascent beneath La Palma revealed by seismic tomography
Authors: D’Auria Luca , Koulakov Ivan , Prudencio Janire , Cabrera-Pérez Iván , Ibáñez Jesús M. , Barrancos Jose , García-Hernández Rubén , Martínez van Dorth David , Padilla Germán D. , Przeor Monika , Ortega Victor , Hernández Pedro , Peréz Nemesio M. 
Published: October 2022

AbstractFor the first time, we obtained high-resolution images of Earth's interior of the La Palma volcanic eruption that occurred in 2021 derived during the eruptive process. We present evidence of a rapid magmatic rise from the base of the oceanic crust under the island to produce an eruption that was active for 85 days. This eruption is interpreted as a very accelerated and energetic process. We used data from 11,349 earthquakes to perform travel-time seismic tomography. We present high-precision earthquake relocations and 3D distributions of P and S-wave velocities highlighting the geometry of magma sources. We identified three distinct structures: (1) a shallow localised region (< 3 km) of hydrothermal alteration; (2) spatially extensive, consolidated, oceanic crust extending to 10 km depth and; (3) a large sub-crustal magma-filled rock volume intrusion extending from 7 to 25 km depth. Our results suggest that this large magma reservoir feeds the La Palma eruption continuously. Prior to eruption onset, magma ascended from 10 km depth to the surface in less than 7 days. In the upper 3 km, melt migration is along the western contact between consolidated oceanic crust and altered hydrothermal material.
Prevelance of depression and anxiety with their effect on quality of life in chronic kidney disease patients
Authors: Alshelleh Sameeha , Alhouri Abdullah , Taifour Alaa , Abu-Hussein Bilal , Alwreikat Faris , Abdelghani Mohammad , Badran Muhannad , Al-Asa’d Yousef , Alhawari Hussein , Oweis Ashraf O. 
Published: October 2022

AbstractChronic kidney disease is one of the most common chronic diseases globally. Many studies have shown it is strongly associated with increased social and psychological problems such as depression and anxiety which are considered as common psychiatric disorders that occur in patients with chronic kidney disease. We investigated the prevalence of depression, anxiety and perception of quality of life in a sample of chronic kidney disease patients at the Jordan University Hospital. We aimed to see any association of the mental health in these patients; mainly depression and anxiety with their quality of life and correlation to socio-demographics or laboratory and metabolic profile of this population. 103 chronic kidney disease patients were interviewed using a questionnaire in the Nephrology outpatient clinics of the Jordan University Hospital, the questionnaire included four sections, the first sections handled socio-demographic data. Also, it contains a brief Clinical and laboratory parameter of our patients. The second part consisted of the 9-item Patient Health Questionnaire (PHQ-9) that used to measure the severity of depression. The third part included the 7-item Generalized Anxiety Disorder (GAD-7) to evaluate the severity of anxiety, the fourth part assessed participants quality of life (QOL) using The World Health Organization Quality of Life, Short Form (WHOQOL-BREF) questionnaire. More than half of the participants have depression and anxiety with a percentage of 58.3% and 50.5%, respectively. There was a negative moderate to strong correlation between depression score and quality of life domains scores (p < 0.001).Only marital status had a significant relationship with depression (p < 0.001).Weak positive correlation between Glomerular Filtration Rate and anxiety score (p = 0.04),with significant positive correlation between lipid profile and anxiety score. There was a negative correlation between anxiety score and quality of life domains scores. Females had higher anxiety score than males (p = 0.27). Patients who do not work had a lower physical functioning score compared to others (p value = 0.024).Patients with higher serum Hemoglobin had higher physical and psychological scores. Anxiety, Depression are common among our chronic kidney disease patients, more interventions are needed to improve the mental health of our patients and their quality of life perception. This kind of study allows us to gain a deeper understanding regarding the effects of chronic kidney disease on psychosocial well-being of those patients, and helps health care providers to put depression, anxiety and Quality of life into consideration when treating patients.
Visual function and retinal changes after voretigene neparvovec treatment in children with biallelic RPE65-related inherited retinal dystrophy
Authors: Testa Francesco , Melillo Paolo , Di Iorio Valentina , Iovino Claudio , Farinaro Francesco , Karali Marianthi , Banfi Sandro , Rossi Settimio , Della Corte Michele , Simonelli Francesca 
Published: October 2022

AbstractTo report quantitative retinal changes assessed by spectral-domain optical coherence tomography (SD-OCT) in children treated with voretigene neparvovec (VN) at a single center in Italy. Retrospective review of six consecutive pediatric patients with biallelic RPE65-related dystrophy treated bilaterally with VN. SD-OCT scans were analyzed to extract Early Treatment Diabetic Retinopathy Study (ETDRS) thickness maps of the whole retina and the outer nuclear layer (ONL). Changes in visual function were assessed by best-corrected visual acuity (BCVA) and retinal morphology at Days 30/45 and 180. BCVA significantly improved at Day 30/45 and 6 months (both P < 0.001). Central foveal retinal thickness and central foveal ONL thickness tended to increase (6.4 ± 19.2 µm; P = 0.080 and 3.42 ± 7.68 µm; P = 0.091, respectively). ONL thickness of the internal ETDRS-ring significantly increased at day 30/45 (4.7 ± 8.4 µm; P < 0.001) and day 180 (5.0 ± 5.7 µm; P = 0.009). Intra-operative foveal detachment was not associated with a higher function gain in terms of BCVA, but with a mild thinning of foveal ONL after treatment. The improvement of BCVA and thickening of the ONL layer suggest that improvement of visual acuity could be related to partial recovery of retinal morphology in the perifoveal ring.
Quantum correlations beyond entanglement in a classical-channel model of gravity
Authors: Roccati Federico , Militello Benedetto , Fiordilino Emilio , Iaria Rosario , Burderi Luciano , Di Salvo Tiziana , Ciccarello Francesco 
Published: October 2022

AbstractA direct quantization of the Newtonian interaction between two masses is known to establish entanglement, which if detected would witness the quantum nature of the gravitational field. Gravitational interaction is yet compatible also with gravitational decoherence models relying on classical channels, hence unable to create entanglement. Here, we show in paradigmatic cases that, despite the absence of entanglement, a classical-channel model of gravity can still establish quantum correlations in the form of quantum discord between two masses. This is demonstrated for the Kafri–Taylor–Milburn (KTM) model and a recently proposed dissipative extension of this. In both cases, starting from an uncorrelated state, a significant amount of discord is generally created. This eventually decays in the KTM model, while it converges to a small stationary value in its dissipative extension. We also find that initial local squeezing on the state of the masses can significanlty enhance the generated discord.
Verification of gait analysis method fusing camera-based pose estimation and an IMU sensor in various gait conditions
Authors: Yamamoto Masataka , Shimatani Koji , Ishige Yuto , Takemura Hiroshi 
Published: October 2022

AbstractA markerless gait analysis system can measure useful gait metrics to determine effective clinical treatment. Although this gait analysis system does not require a large space, several markers, or time constraints, it inaccurately measure lower limb joint kinematics during gait. In particular, it has a substantial ankle joint angle error. In this study, we investigated the markerless gait analysis method capability using single RGB camera-based pose estimation by OpenPose (OP) and an inertial measurement unit (IMU) sensor on the foot segment to measure ankle joint kinematics under various gait conditions. Sixteen healthy young adult males participated in the study. We compared temporo-spatial parameters and lower limb joint angles during four gait conditions with varying gait speeds and foot progression angles. These were measured by optoelectronic motion capture, markerless gait analysis method using OP, and proposed method using OP and IMU. We found that the proposed method using OP and an IMU significantly decreased the mean absolute errors of peak ankle joint angles compared with OP in the four gait conditions. The proposed method has the potential to measure temporo-spatial gait parameters and lower limb joint angles, including ankle angles, in various gait conditions as a clinical settings gait assessment tool.
Vision contributes to sex differences in spatial cognition and activity interests
Authors: Qian Yiming , Berenbaum Sheri A. , Gilmore Rick O. 
Published: October 2022

AbstractSex differences in a variety of psychological characteristics are well-documented, with substantial research focused on factors that affect their magnitude and causes. Particular attention has focused on mental rotation, a measure of spatial cognition, and on activity interests. We studied whether sex differences in visual perception—luminance contrast thresholds and motion duration thresholds—contribute to sex differences in mental rotation and interest in male-typed activities. We confirmed sex differences in vision, mental rotation, and activity interests in a sample of 132 college students. In novel findings, we showed that vision correlated with mental rotation performance in women, that vision was a better predictor of individual differences in mental rotation than sex, and that contrast thresholds correlated with women’s interest in male-typed activities. These results suggest that sex differences in spatial cognition and activity interests may have their roots in basic perceptual processes.
Pigment signatures of algal communities and their implications for glacier surface darkening
Authors: Halbach Laura , Chevrollier Lou-Anne , Doting Eva L. , Cook Joseph M. , Jensen Marie B. , Benning Liane G. , Bradley James A. , Hansen Martin , Lund-Hansen Lars C. , Markager Stiig , Sorrell Brian K. , Tranter Martyn , Trivedi Christopher B. , Winkel Matthias , Anesio Alexandre M. 
Published: October 2022

AbstractBlooms of pigmented algae darken the surface of glaciers and ice sheets, thereby enhancing solar energy absorption and amplifying ice and snow melt. The impacts of algal pigment and community composition on surface darkening are still poorly understood. Here, we characterise glacier ice and snow algal pigment signatures on snow and bare ice surfaces and study their role in photophysiology and energy absorption on three glaciers in Southeast Greenland. Purpurogallin and astaxanthin esters dominated the glacier ice and snow algal pigment pools (mass ratios to chlorophyll a of 32 and 56, respectively). Algal biomass and pigments impacted chromophoric dissolved organic matter concentrations. Despite the effective absorption of astaxanthin esters at wavelengths where incoming irradiance peaks, the cellular energy absorption of snow algae was 95% lower than anticipated from their pigmentation, due to pigment packaging. The energy absorption of glacier ice algae was consequently ~ 5 × higher. On bare ice, snow algae may have locally contributed up to 13% to total biological radiative forcing, despite contributing 44% to total biomass. Our results give new insights into the impact of algal community composition on bare ice energy absorption and biomass accumulation during snow melt.
Different timing and risk factors of cause-specific pancreas graft loss after simultaneous pancreas kidney transplantation
Authors: Tomimaru Yoshito , Kobayashi Shogo , Ito Toshinori , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Noda Takehiro , Takahashi Hidenori , Kenmochi Takashi , Doki Yuichiro , Eguchi Hidetoshi 
Published: October 2022

AbstractIn cases after pancreas transplantation (PTx), the pancreas graft might be lost for various reasons, including a pancreatoduodenal graft-related complication or patient death with a functioning graft. Although the causes seem to have distinct characteristics, the causes of pancreas graft loss have not been characterized. This study aimed to characterize the causes of pancreas graft loss by analyzing data from a Japanese nationwide registry. This study included 391 patients who received simultaneous pancreas-kidney transplantation among 461 patients with PTx during the study period in approved institutions in Japan. We characterized each cause in terms of the timing of the cause-specific graft loss and preoperative factors associated with graft loss based on nationwide data from a Japanese nationwide registry. Among the 391 cases, 113 lost the pancreas graft due to patient death with a functioning graft (DWFG; n = 34, 44.2%), graft thrombus (n = 22, 28.6%), or chronic rejection (CR; n = 7, 9.1%). Average (± standard deviation) time from PTx to graft loss due to DWFG, graft thrombus, and CR was 3.70 ± 4.36, 0.02 ± 0.01, and 2.37 ± 2.08 years, respectively. Duration of type 1 diabetes mellitus and donor body mass index were significantly associated with pancreas graft loss due to DWFG and graft thrombus, respectively. This characterization showed that the timing and preoperative factors associated with pancreas graft loss were significantly different for different causes of graft loss. These results may inform PTx follow-up protocols to ensure that appropriate care is based on the cause of graft loss.
Female bonobos show social swelling by synchronizing their maximum swelling and increasing bonding
Authors: Demuru Elisa , Caselli Marta , Guéry Jean-Pascal , Michelet Carole , Alexieff Franck , Norscia Ivan 
Published: October 2022

AbstractDifferent Old World primates show conspicuous anogenital swelling, with the Maximum Swelling Phase (MSP) signaling the ovulatory phase. MSP synchronization between females has been linked to social dynamics. In bonobos, characterized by female dominance, MSP is not a fully reliable signal of fertility because it may cover anovulatory periods. We investigated whether bonobo females synchronized their MSP and whether this phenomenon was modulated by social factors. Data were collected at LaValléedesSinges (France). In the period 2009–2022, swelling cycles data were collected daily on bonobo females (N = 9). In the period 2018–2022, ethological data (aggression/affiliation/socio-sexual behaviors) were also collected. We found that: (i) females synchronized their MSP and most likely experienced MSP onset following the MSP onset in other females; (ii) synchronization increased as the years spent together by females increased; (iii) synchronization preferentially occurred between females that affiliated less; (iv) synchronization on the MSP was linked to increased female-female socio-sexual contacts, which probably favored MSP synchronization maintenance. Hence, in bonobos MSP can be modulated by social factors and its synchronization, possibly underlying autonomic contagion, might have been positively selected during evolution in relation to the benefits females obtain in terms of intra-group cohesion.
Generation and characterization of a Müller-glial-cell-specific Il6ra knockout mouse to delineate the effects of IL-6 trans-signaling in the retina
Authors: Robinson Rebekah , Glass Joshua , Sharma Ashok , Sharma Shruti 
Published: October 2022

AbstractInterleukin-6 (IL-6) is implicated in various retinal and vascular complications associated with diabetic retinopathy (DR). This cytokine functions through two main modalities: classical signaling, in cells expressing the membrane-bound receptor (IL-6Rα); and trans-signaling, possible in most cells through a soluble form of the receptor (sIL-6R). These pathways are considered to be anti-inflammatory and pro-inflammatory, respectively. Our recent studies in retinal endothelial cells and diabetic mice have shown that inhibiting only IL-6 trans-signaling is sufficient to prevent increased vascular leakage, oxidative stress, and inflammation characteristic of DR. Isolating the specific effects of each signaling pathway, however, remains difficult in cells expressing IL-6Rα that are thus capable of both classical and trans-signaling. Müller glial cells (MGCs), the most abundant retinal macroglial cells, span the entire retinal thickness with vital roles in maintaining retinal homeostasis and regulating the blood-retinal barrier through secreted factors. The specific effects of IL-6 trans-signaling in MGCs remain poorly understood given their responsiveness to both IL-6 signaling modalities. In this study, we addressed these concerns by generating an MGC-specific knockout mouse using Cre-loxPdeletion of theIl6racytokine-binding region. We assessed transcriptional and translationalIl6raexpression to confirm the knockout and characterized the effects of knockout on visual functioning in these mice.
GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting
Authors: Barahona M. J. , Langlet F. , Labouèbe G. , Croizier S. , Picard A. , Thorens Bernard , García-Robles María A. 
Published: October 2022

AbstractFeeding behavior is a complex process that depends on the ability of the brain to integrate hormonal and nutritional signals, such as glucose. One glucosensing mechanism relies on the glucose transporter 2 (GLUT2) in the hypothalamus, especially in radial glia-like cells called tanycytes. Here, we analyzed whether a GLUT2-dependent glucosensing mechanism is required for the normal regulation of feeding behavior in GFAP-positive tanycytes. Genetic inactivation of Glut2 in GFAP-expressing tanycytes was performed using Cre/Lox technology. The efficiency of GFAP-tanycyte targeting was analyzed in the anteroposterior and dorsoventral axes by evaluating GFP fluorescence. Feeding behavior, hormonal levels, neuronal activity using c-Fos, and neuropeptide expression were also analyzed in the fasting-to-refeeding transition. In basal conditions, Glut2-inactivated mice had normal food intake and meal patterns. Implementation of a preceeding fasting period led to decreased total food intake and a delay in meal initiation during refeeding. Additionally, Glut2 inactivation increased the number of c-Fos-positive cells in the ventromedial nucleus in response to fasting and a deregulation of Pomc expression in the fasting-to-refeeding transition. Thus, a GLUT2-dependent glucose-sensing mechanism in GFAP-tanycytes is required to control food consumption and promote meal initiation after a fasting period.
Study of the electromechanical coupling process before the 2020 Ms 6.4 Yutian, China earthquake
Authors: Yu Chen , Wang Shuyan , Yu Huaizhong 
Published: October 2022

AbstractThe observation of electromechanical coupling might be used as an important tool to detect pre-seismic changes associated with the preparation of earthquakes. This paper attempts to study the electromechanical coupling process before the large earthquakes by using the load/unload response ratio (LURR) approach in which the geo-electric data and Benioff strain of small earthquakes were adopted as the data input. The variation of Coulomb failure stress induced by earth tides on the fault surface of the mainshock is applied to differentiate the loading and unloading stages. Using this technique, we test the geo-electric data recorded at the Hotan observatory near the epicenter of 2020 Yutian Ms 6.4 earthquake. Results show that the LURR time sequence fluctuated around 1.0 for many years and reached significant high peaks at the beginning of 2020. More importantly, this evolution correlates well with the LURR time series calculated by using the Benioff strain of small earthquakes within the circular region of 300 km radius centered at the epicenter. The underlying physics of the changes should be caused by the fluid infiltration derived from pre-seismic rock dilatancy. The corresponding volume variations in the crust could be found in the geophysical observation time series in the same neighborhoods.
Refining the stress gradient hypothesis for mixed species groups of African mammals
Authors: Kiffner Christian , Boyle Diana M. , Denninger-Snyder Kristen , Kissui Bernard M. , Waltert Matthias , Krause Stefan 
Published: October 2022

AbstractSpecies interactions such as facilitation and predation influence food webs, yet it is unclear how they are mediated by environmental gradients. Here we test the stress gradient hypothesis which predicts that positive species interactions increase with stress. Drawing upon spatially-explicit data of large mammals in an African savanna, we tested how predation risk and primary productivity mediate the occurrence of mixed species groups. Controlling for habitat structure, predation risk by lions and primary productivity affected the frequency of mixed species groups in species-specific ways, likely reflecting distinct stress perceptions. To test whether mixed species groups indicate positive interactions, we conducted network analyses for specific scenarios. Under predation risk, dyadic associations with giraffes were more pronounced and metrics of animal networks changed markedly. However, dyadic association and network metrics were weakly mediated by primary productivity. The composition of mixed species groups was associated with similarities in prey susceptibility but not with similarities in feeding habits of herbivores. Especially predation risk favoured the frequency of mixed species groups and pronounced dyadic associations which dilute predation risk and increase predator detection. While our results provide support for the stress gradient hypothesis, they also highlight that the relative importance of stressors is context-dependent.
A novel variant in TLE6 is associated with embryonic developmental arrest (EDA) in familial female infertility
Authors: Akbari Mojdeh , Mohebi Mehdi , Berjis Katayon , Ghahremani Amin , Modarressi Mohammad Hossein , Ghafouri-Fard Soudeh 
Published: October 2022

AbstractThis study aims to identify genetic causes of familial female infertility characterized by embryonic developmental arrest (EDA) and repeated implantation failure (RIF) with oocyte donation IVF cycle. We used Whole-exome sequencing and Sanger validation to find causative genes in an Iranian consanguineous family that had 3 infertile daughters, 4 fertile daughters, and 2 fertile sons. All patients in this consanguineous family exhibited typical manifestations of unexplained RIF and EDA. Genetic analysis identified a homozygous missense variant (c.G1054C:p.G352R) in exon 13 of theTLE6gene that cosegregated with the EDA phenotype in an autosomal recessive pattern. Other members of the family, the gene carriers, remain clinically asymptomatic and fertile. Our findings identify a novel nonsynonymous variant, c.G1054C:p.G352R, in theTLE6gene within a consanguineous Iranian family with autosomal-recessive female infertility and broaden the genetic spectrum ofTLE6-associated EDA.