bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of water vapor sources and precipitation contributions to drought and wet events on the Chinese Loess Plateau
Authors: Liu Rong , Wang Xin , Wang Zuoliang , Quan Rui 
Published: September 2022

Abstract
In this paper, the standardized precipitation evapotranspiration index (SPEI) at the monthly scale was calculated based on ground observations to obtain different drought and wet events at the surface of the Loess Plateau in summer from 2000-2017. Using the NECP FNL (National Centers for Environmental Prediction Final) data for the same period, backward simulations with the FLEXPART model were performed to obtain the water vapor transport characteristics and potential evaporative sources corresponding to different dry and wet events. Finally, the contribution of water vapor sources to precipitation on the Loess Plateau was obtained. The results show that the primary sources of water vapor on the Loess Plateau during dry and wet summer events are concentrated in the Loess Plateau and the Yunnan-Kweichow Plateau regions and sporadically distributed in the Altay region of Xinjiang, as well as at the junction of China, Kazakhstan and Mongolia. The evaporation extent and intensity in northern Xinjiang and Mongolia increase when the surface experiences wet-normal-dry events. The local internal circulation on the Loess Plateau contributes to 31.3% and 36.8% of the water vapor in drought and wet events, respectively. Influenced by the westerly wind belt and southwest monsoon, the precipitation contributions of the Yunnan-Kweichow Plateau are 11.2% and 13.1%, respectively, and those of Mongolia are 14.6% and 11.9%, respectively. The water vapor contributions from the Arabian Sea and Bay of Bengal in the south are insignificant. The results aid in understanding the mechanisms of drought and wet events on the Loess Plateau.
Idiopathic intracranial hypertension presenting with migraine phenotype is associated with unfavorable headache outcome
Authors: Bsteh Gabriel , Macher Stefan , Krajnc Nik , Pruckner Philip , Marik Wolfgang , Mitsch Christoph , Novak Klaus , Pemp Berthold , Wöber Christian 
Published: September 2022

Abstract
Background: Migrainous headache is common in idiopathic intracranial hypertension (IIH). The aim of this study was to assess its prognostic impact.Methods: We investigated patients with IIH from the Vienna-IIH-database and differentiated migraine (IIH-MIG) from non-migrainous and absent headache (IIH-noMIG). Using multivariate models, we analyzed the impact of IIH-MIG on headache and visual outcomes 12 months after diagnosis. Results: Among 97 patients (88.7% female, mean age 32.9±11.1 years, median BMI 32.0, median CSF opening pressure 31cmH2O), 46.4% were assigned to IIH-MIG and 53.6% to IIH-noMIG (11.3% tension-type, 25.8% unclassifiable, 16.5% no headache). At baseline, IIH-MIG differed from IIH-noMIG with respect to headache frequency (22 vs. 15 days/month, p=0.003) and severity (6.5/10 vs. 4.5/10; p<0.001).At follow-up, the rates for improvement and freedom of headache were lower in IIH-MIG than in IIH-noMIG for all patients (66.7% vs. 88.5%, p=0.009; 11.1% vs. 42.3%, p=0.006) and for those with resolution of papilledema (n=60; 62.1% vs. 93.6%, p=0.003; 17.2% vs. 61.3%, p<0.001). In contrast, visual worsening was significantly less common in IIH-MIG (8.9% vs. 25.0%, p=0.037). Adjusting for covariates, IIH-MIG was independently associated with a significantly lower likelihood of headache improvement (odds ratio [OR] 0.57, p<0.001) and freedom of headache (OR 0.28, p<0.001), but also a lower risk for visual worsening (OR 0.39, p<0.001). Conclusions: In IIH, migrainous headache is associated with unfavorable outcomes for headache, even when papilledema has resolved, and possibly favorable visual outcome.
Effects of new-generation antiepileptic drug prophylaxis on delayed neurovascular events after aneurysmal subarachnoid hemorrhage
Authors: Suzuki Hidenori , Miura Yoichi , Yasuda Ryuta , Yago Tetsushi , Mizutani Hisashi , Ichikawa Tomonori , Miyazaki Takahiro , Kitano Yotaro , Nishikawa Hirofumi , Kawakita Fumihiro , Fujimoto Masashi , Toma Naoki 
Published: September 2022

Abstract
Neuroelectric disruptions such as seizures and cortical spreading depolarization may contribute to the development of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH). However, effects of antiepileptic drug prophylaxis on outcomes remain controversial in SAH. The authors investigated if prophylactic administration of new-generation antiepileptic drugs levetiracetam and perampanel was beneficial against delayed neurovascular events after SAH. This was a retrospective single-center cohort study of 121 consecutive SAH patients including 56 patients of admission World Federation of Neurological Surgeons grades IV−V who underwent aneurysmal obliteration within 72 hours post-SAH from 2013 to 2021. Prophylactic antiepileptic drugs differed depending on the study terms: none (2013−2015), levetiracetam for patients at high risks of seizures (2016−2019), and perampanel for all patients (2020−2021). The 3rd term had the lowest occurrence of delayed cerebral microinfarction on diffusion-weighted magnetic resonance imaging and the tendency of reduced DCI. Other outcome measures were similar among the 3 terms including incidences of angiographic vasospasm, computed tomography-detectable delayed cerebral infarction, seizures, and 3-month good outcomes (modified Rankin Scale 0−2). The present study suggests that prophylactic administration of levetiracetam and perampanel at least does not worsen outcomes, and that perampanel may have the potential to reduce DCI by preventing microcirculatory disturbances after SAH. Further studies are warranted to investigate anti-DCI effects of a selective α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist perampanel in SAH patients in a large-scale prospective study.
Identification of fruit fly (Tephritidae) pupae parasitized by Hymenoptera parasitoids
Authors: de Almeida Tiago Tognolli , Roel Antonia Railda , de Oliveira Carina Elisei , Rocha Bruno Fines , Dias Angélica Maria Penteado Martins 
Published: September 2022

Abstract

Introduction One of the major problems in orchards is the presence of Tephritidae fly maggots, especially in Mirtaceae species. Various biological control tools include the use of Hymenoptera parasitoids, which naturally control fly populations. However, identification of the host species of parasitoids is challenging, because only the puparium remains after the parasitoid hatches. Aims Therefore, the aim of this work was to determine the host species of Hymenoptera parasitoids, through the puparium. Methods Host species were identified by amplification and sequencing of cytochrome C oxidase subunit I (COI) of mitochondrial DNA. Results The results of the present study show that COI DNA sequencing was able to reliably identify host pupae to the genus level, allowing the identification of the Anastrepha genus in this study. Discussion This suggests that this method can be used to identify agriculturally relevant host pupae, since this genus has already been described as a parasite of Campomanesia adamantium. Implications for insect conservation Knowledge of the species that cause damage to crop, and their parasitoids is extremely important to study the biological and ecological aspects of these pests and their control. In this way, our results can contribute to the development of alternatives to the use of insecticides, reducing the use of chemical agents in crop production and minimizing the harmful effects on other insect species.
Evaluation of the Safety and Potential Therapeutic Effects of Hydrogen-Rich Coral Calcium on Autoimmune Diseases
Authors: Shen Min-Chung , Chung Jia-Ru Chung , Wang Kuang-Yih , Chu Chao-Fang , Tsou Wen-Hsin , Chou Hsia-Yun , Wang Tian-Yu , Chang Tzu-Hao , Chen Wen-Wen , Liu Feng-Cheng , Douglas Frank L. , Hsieh Rong-Hong 
Published: September 2022

Abstract
Patients with autoimmune diseases (AD) are at increased risk of complications, which adversely affect the quality of life and prognosis. Recently, a large amount of literature suggested reduced oxidative stress by hydrogen supplements in reducing inflammation and improving prognosis. In this study, clinical trial NCT05196295, we randomly assigned different dosages (low, medium, and high) of hydrogen-rich coral calcium (HRCC) to patients with autoimmune diseases, including Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) patients in Ming-Sheng Hospital in Taiwan (age 54 years, 80% females). Participants were measured with their baseline health biomarkers including inflammatory indicators, haematologic, urinary biomarkers, and health status prior to the trial. Clinical and follow-up assessments were collected after 1 month of the treatment. We performed analyses to compare the baseline with the changes after the HRCC treatment. Together with the groups treated with different dosages, the treatment demonstrated no adverse effects on participants’ responses to the HRCC. While the primary endpoint of the trial was met, the potential therapeutic effects of HRCC are addressed for future studies. This clinical trial of HRCC in safety response is the first-in-human study.
Spatio-Temporal adaptive correlation filter tracking based on multi- layer convolution feature fusion
Authors: Jiang Wentao , Meng Qingjiao 
Published: September 2022

Abstract
Aiming at the disadvantage that the term of regularization filter is defined in advance, but it can not suppress the learning of non target region in real time. A new method of multi-layer convolution feature fusion Spatio-Temporal adaptive correlation filter tracking is propose. Firstly, the spatial local response variation is introduced into the objective function to realize spatial regularization, so that the filter focuses on the trusted part of the learning object, so as to obtain the response model. Secondly, the update rate of the filter is determined according to the change of global response. Finally, the convolution neural network (CNN) is introduced for depth feature extraction. The feature level fusion is realized by cascading gray, color name (CN) and histogram of oriented gradient (HOG) features. Sobel operator is used to reduce the dimension combined with pooling layer, and ReLU activation function. function is used to retain the location information about main features and speed up the calculation speed. Two benchmark experimental sets showed that the algorithm basically meets the real-time requirements in complex background, object occlusion, fast motion and other scenes.
COMFORTneo scale: a reliable and valid instrument to measure prolonged pain in neonates?
Authors: Meesters Naomi , Diles Tinne , Rosmalen Joost van , Bosch Gerbrich van den , Simons Sinno , Dijk Monique van 
Published: September 2022

Abstract
Objective We studied the reliability and validity of the COMFORTneo scale, designed to measure neonatal prolonged pain. Study designThis prospective observational study evaluated four clinimetric properties of the COMFORTneo scale from NICU nurses’ assessments of neonates’ pain. Intra-rater reliability was determined from three video fragments at two time points. Inter-rater reliability and construct validity were determined in five neonates per nurse with the COMFORTneo and numeric rating scales (NRS) for pain and distress. Pain scores using N-PASS were correlated with COMFORTneo scores to further evaluate construct validity.ResultIntra-rater reliability: Twenty-two nurses assessed pain twice with an intraclass correlation coefficient (ICC) of 0.70. Inter-rater reliability: The ICC for 310 COMFORTneo scores together with 62 nurses was 0.93. Construct validity: Correlation between COMFORTneo and NRS pain, distress and N-PASS was 0.34, 0.72 and 0.70, respectively. ConclusionThe COMFORTneo can be used to reliably and validly assess pain in NICU patients.
68Ga-PSMA-11 PET/CT imaging in elderly patients with newly-diagnosed prostate cancer, with and without pre-imaging biopsy
Authors: Kesler Mikhail , Cohen Dan , Levine Charles , Sarid David , Keizman Daniel , Yossepowitch Ofer , Even-Sapir Einat 
Published: September 2022

Abstract
Purpose
to assess the value of staging 68Ga-PSMA-11 PET/CT in elderly patients with biopsy-proven or high clinical suspicion of prostate cancer (PCa).
Methods
100 consecutive patients 80 years of age and older referred for 68Ga-PSMA-11 PET/CT with biopsy proven high-risk PCa (n = 66 pts) or high clinical suspicion of clinically relevant PCa without biopsy (n = 34 pts) were enrolled. Clinical parameters, biopsy results (when performed), 68Ga-PSMA-11 PET/CT findings and treatment approach wererecorded. Patients were categorized to those that had a pre-imaging biopsy B(+) and those that did not B(-).
Results
All patients had a PSMA-avid disease including the 34 B(-) patients in whom a focal "hot" lesion was identified in the prostate suggestive of the primary tumor lesion. Based on 68Ga-PSMA-11 PET/CT, 36 patients had a localized disease 25 patients had a locally advanced disease and 39 had an advanced disease. Lesions requiring a special clinical attention were identified. B(-) patients were older (median age 87 vs. 82, Pv < 0.01), with worse performance status (Pv < 0.01), and higher PSA levels (median 57 vs. 15.4 ng/ml, Pv < 0.01). Staging was not different in B(+) and B (-) patients, but the latter showed a trend for higher rates of bone metastases (47.1% vs. 28.8%) and overall advanced disease (50% vs. 33.3%). All Patients with advanced disease but one (38/39), received hormonal therapy, whether they had a pre-imaging biopsy or not. Focusing on the 16 B (-) patients showing advanced disease on 68Ga-PSMA-11 PET/CT and receiving hormonal therapy, in 92.3% patients decrease in PSA levels was achieved (mean ∆PSA, 95.6%, IQR, 95.0-98.2%) and in 88.9% follow-up 68Ga-PSMA-11 PET/CT showed improvement or stable disease.
Conclusion
Elderly patients often referred for 68Ga-PSMA-11 PET/CT when diagnosis of high-risk PCa is biopsy-proven or without a pre-imaging biopsy, when presenting with clinically suspected PCa. 68Ga-PSMA-11 PET/CT findings allow for accurate staging and assist in guiding treatment. Many elderly patients may benefit same treatment applied in younger patients. If did not undergo biopsy, treatment may be chosen based on imaging findings alone.
Functional improvements in β-conglycinin by edible bioconjugation with carboxymethyl dextran
Authors: Yoshida Tadashi , Tomono Misato , Takahashi Ryohei , Hattori Makoto 
Published: September 2022

Abstract
β-Conglycinin was conjugated with carboxymethyl dextran (CMD) by the Maillard reaction to improve its function. The β-conglycinin-CMD conjugate was purified by dialysis. Conjugation was confirmed by SDS-PAGE with CBB and PAS staining. Composition of the β-conglycinin-CMD was β-conglycinin:CMD = 1:2.7 (molar ratio) which was confirmed by BCA method and phenol sulfuric acid method. Solubility of β-conglycinin in the range of pH 2.0–7.0 was much improved by conjugation with CMD. Emulsifying property of β-conglycinin at pH 7 and in presence of salt was improved by conjugation with CMD. Immunogenicity of β-conglycinin was reduced by conjugation with CMD. Conjugation method performed in this study was considered to be valuable in that it can be used in food processing.
Evaluation of ROS1 expression and rearrangements in a large cohort of early- stage lung cancer
Authors: Dyrbekk Anne Pernille Harlem , Warsame Abdirashid Ali , Suhrke Pål , Ludahl Marianne Odnakk , Moe Joakim Oliu , Eide Inger Johanne Zwicky , Lund-Iversen Marius , Brustugun Odd Terje 
Published: September 2022

Abstract
Background: ROS1 fusion is an infrequent, but attractive target for therapy in patients with metastatic non- small-cell lung cancer. In studies on mainly late-stage disease, the prevalence of ROS1 fusions is about 1-3%. Less is known about the prevalence of ROS1 fusions in early-stage, resectable lung cancer, where it might provide a fruitful target for neoadjuvant or adjuvant therapy. In the present study, we investigated the prevalence of ROS1 fusion in early-stage lung cancer. We also explored whether positive ROS1 immunohistochemical (IHC) stain was associated with certain mutations, clinical characteristics and outcomes. Methods: The study was performed using biobank material from 972 lung cancer patients including 542 patients with adenocarcinoma surgically resected during 2006-2018. Initially, we screened the samples with two different IHC clones (D4D6 and SP384) targeting ROS1. All samples that showed more than weak or focal staining, as well as a subgroup of negative samples, were analyzed with ROS1 fluorescence in situ hybridization (FISH) and next-generation sequencing (NGS) with a comprehensive NGS DNA and RNA panel. Positive ROS1-fusion was defined as those samples positive in at least two of the three methods (IHC, FISH, NGS). Results: Fifty cases were IHC positive. Of these, three samples were both NGS and FISH-positive and considered positive for ROS1 fusion. Two more samples were FISH positive only, and whilst IHC and NGS were negative. The prevalence of ROS1 fusion in adenocarcinomas was 0.6%. All cases with ROS1 fusion had TP53 mutations. IHC-positivity was associated with adenocarcinoma. Among SP384-IHC positive cases we also found an association with never smoking status. There was no association between positive IHC and overall survival, age, stage, sex or pack-year of smoking. Conclusions: ROS1 seems to be less frequent in early-stage disease than in advanced stages. IHC is a sensitive, but less specific method and the results need to be confirmed with another method like FISH or NGS.
Proposal for a tiered approach to evaluate the risk of transformation products formed from pesticides residues during drinking water treatment
Authors: Michel Amandine , Armbruster Dominic , Benz-Birck Angelika , Deppermann Nina , Doetzer Reinhard , Flörs Markus , Frericks Markus , Li Shanghua , Gebler Sebastian , Schröder Tom , Seitz Wolfram 
Published: September 2022

Abstract
Oxidative treatment methods are valuable tools for the microbial safety of drinking water. However, the reaction of oxidants with natural substances or anthropogenic contaminants present in the raw water can potentially lead to the formation of harmful transformation products (TPs). The present paper proposes a tiered approach for the risk evaluation of TPs formed from pesticides residues during drinking water treatment. First, the concentrations of pesticides residues in raw water used for drinking water production are evaluated (step 1). Substances with a predicted concentration in raw water above 0.1 µg/L proceed further to a reactivity assessment, examining the behaviour in water treatment plants (step 2). Using information available in the scientific literature, prediction of structural elements in the TPs can be made and allow a worst-case assessment based on the Threshold of Toxicological Concern (TTC) (step 3). If concerns remain, experiments may be conducted to simulate water treatment (step 4). Because of their complexity and variability, experiments for the simulation of water treatment should focus on prioritized substances of potential concern. The test conditions should be realistic (i.e., close to EU-representative conditions in waterworks) and ozonation and chlorination should be combined with pre- and post-treatment steps, as is normally the case in European waterworks. As a first screening option, we propose to test the toxicity of the reaction mixture. If the treated water shows an enhanced toxicity, further experiments can be conducted to identify and quantify the major TPs (step 5). We propose to define major TPs as substances present at more than 10% of the initially applied test substance. For major TPs a tiered dietary risk assessment is conducted, starting with the TTC concept, and continuing with toxicity testing of the TP, according to EFSA and ECHA and internationally agreed guidance.
Diffusion-induced stresses due to an impulsive mass source under non-Fickian mass transfer models
Authors: Fayik Mohsen , Dhaba Amr El , Awad Emad 
Published: September 2022

Abstract
The description of the mass transfer mechanisms in various physical and engineering fields, e.g., Li-ion battery, is of a significant importance for optimizing their performance. The present work introduces a comparative study describing the different responses of a perfectly elastic material when different non-Fickian diffusion situations are considered. The uncoupled theory of elastic diffusion, in which the diffusion process is described by non-Fickian laws, such as Cattaneo, Jeffreys-type and Burgers-type constitutive laws, is employed in this modeling. Diffusion of lithium ions inside the silicon anode is one of the physical situations in which diffusion-induced stresses may be significant. An impulsive initial value problem, consisting of an initial lithium ions amount starts impulsively to diffuse over the entire space of a silicon material, is considered. Direct approach together with Laplace and exponential Fourier transforms techniques are employed to obtain the solution in the Laplace transformed domain. Inverse Laplace transform is computed numerically to obtain the solution in the physical domain. Comparisons among the material responses to different diffusion regimes are presented.
Machine Learning for Control Systems Security of Industrial Robots: a Post-covid-19 Overview
Authors: Gueye Thierno , Wang Yanen , Rehman Mudassar , Mushtaq Ray Tahir , Hassan Abual 
Published: September 2022

Abstract
The Internet of Things has provided people with a seamless, automated home and industrial experience. The concept is now integrated into more domains like Internet of robotic things (IoRT), Internet of medicine Things (IoMT), etc., to improve domain-specific outcomes. For IoRT, which is the robotics implementation of Internet of Things (IoT), poor network security could cause economic and physical damage to both the networked devices and human users of the network. Also, the tendency for data and privacy breaches becomes more prevalent with an increase in the number of devices in the network. Hence, these identified vulnerabilities are the limiting elements for proper IoRT implementation. Various works have proposed security schemes for ensuring the realization of a secure and efficient IoRT network, but with computational time and complexity limitations. However, machine learning methodologies have shown the best promise for identifying malicious traffic in an IoRT network. This work proposes a security architecture using a Deep Neural Network and an ensemble of Decision Trees. This architecture can be implemented online or offline with minimal trade-offs between resources and efficiency. Also, the proposed machine learning models are compared with other commonly implemented schemes using the IoT-23 Dataset. Experimentation and comparison show that the proposed model and architecture are optimal for the malware detection task and security of a typical IoRT network. These contributions are significant for realizing secure and efficient IoRT networks for the future of industrial automation in this post-COVID era.