bluuebunny/crossref_metadata_2025_split huggingface dataset:
Política educativa y construcciones escolares en el Distrito de La Victoria (Perú) durante el gobierno de Odría, 1948-1956
Authors: Martinez Mendoza Juan Marcos 
Published: December 2022

El gobierno de Manuel A. Odría (1948-1956) es recordado en el Perú como uno de los que mejor tendió el problema de la falta de planteles escolares durante el siglo XX; sin embargo, en la construcción de una visión general de su obra educativa, se ha omitido hablar sobre ciertos temas como el descuido del régimen hacia las escuelas primarias, los efectos que tuvieron las primeras migraciones intensas —del campo a la ciudad— sobre los planteles de la capital y los críticos años finales que mermaron la obra educativa del gobierno.
En el presente artículo se busca dar una mirada general de la política educativa de Odría, haciendo hincapié en las construcciones escolares, para lo cual se ha tomado como escenario de estudio el distrito capitalino de La Victoria. Mediante el estudio de documentos oficiales e información extraída de la prensa, se da cuenta de que el gobierno tuvo una preferencia por la educación secundaria y técnica que terminó afectando a la construcción de escuelas; y que a partir de 1953 la obra educativa de Odría mermó debido a factores políticos, económicos y sociales.
About the Efficacy of Virtual and Remote Laboratories in STEM Education in Secondary School: A Second-Order Systematic Review
Authors: Fadda Daniela , Salis Carole , Vivanet Giuliano 
Published: December 2022

Online laboratories brought new opportunities for instruction. In this work, a secondorder systematic review about the efficacy of virtual and remote labs on learning in high school STEM education is presented. Nine systematic review and a meta-analysis were included. A descriptive summary (qualitative and quantitative) of their findings is provided. On average, online laboratories support learning to an extent comparable to that observed in real labs; their effect is even more positive when they are integrated into more traditional teaching practice (e.g., as pre-lab practice sessions before the hands-on experiments) and when they are supported by adequate teacher feedback. Content knowledge is the learning outcome most often assessed; while practical and inquiry skills related to scientific reasoning are investigated less frequently. The results are promising for instructional design and for the future research, despite the data variability and some methodological limitations of individual studies (lack of relevant quantitative data, such as effect sizes and moderator analysis). Further experimental research is required to estimate the effect of online labs on different learning outcomes and to better understand the moderating role of some variables related to interventions and students.
Engineering the Electronic Structure of Single‐Atom Iron Sites with Boosted Oxygen Bifunctional Activity for Zinc–Air Batteries
Authors: Li Zhijun , Ji Siqi , Xu Chang , Leng Leipeng , Liu Hongxue , Horton J. Hugh , Du Lei , Gao Jincheng , He Cheng , Qi Xiaoying , Xu Qian , Zhu Junfa 
Published: December 2022

AbstractRechargeable zinc–air batteries typically require efficient, durable, and inexpensive bifunctional electrocatalysts to support oxygen reduction/evolution reactions (ORR/OER). However, sluggish kinetics and mass transportation challenges must be addressed if the performance of these catalysts is to be enhanced. Herein, a strategy to fabricate a catalyst comprising atomically dispersed iron atoms supported on a mesoporous nitrogen‐doped carbon support (Fe SAs/NC) with accessible metal sites and optimized electronic metal–support interactions is developed. Both the experimental results and theoretical calculations reveal that the engineered electronic structures of the metal active sites can regulate the charge distribution of Fe centers to optimize the adsorption/desorption of oxygenated intermediates. The Fe SAs/NC containing Fe1N4O1 sites achieves remarkable ORR activity over the entire pH range, with half‐wave potentials of 0.93, 0.83, and 0.75 V (vs reversible hydrogen electrode) in alkaline, acidic, and neutral electrolytes, respectively. In addition, it demonstrates a promising low overpotential of 320 mV at 10 mA cm−2 for OER in alkaline conditions. The zinc–air battery assembled with Fe SAs/NC exhibits superior performance than that of Pt/C+RuO2 counterpart in terms of peak power density, specific capacity, and cycling stability. These findings demonstrate the importance of the electronic structure engineering of metal sites in directing catalytic activity.
Rational Design of De Novo CCL2 Binding Peptides
Authors: Aguas Erika Davidoff , Azizogli Abdul‐Rahman , Kashyap Jatin , Dodd‐o Joseph , Siddiqui Zain , Sy Jay , Kumar Vivek 
Published: December 2022

AbstractChronic levels of inflammation lead to autoimmune diseases such as rheumatoid arthritis and atherosclerosis. A key molecular mediator responsible for the progression of these diseases is Chemokine C–C motif ligand 2 (CCL2), a homodimerized cytokine that dissociates into monomeric form and binds to the CCR2 receptor. CCL2, also known as monocyte chemoattractant protein‐1 (MCP‐1), attracts monocytes to migrate to areas of injury and mature into macrophages, leading to positive feedback inflammation with further release of proinflammatory molecules such as IL‐1β and TNF‐α. Sequestering CCL2 to prevent its binding to CCR2 may prevent this inflammatory activity. Prior work adapted an α‐helical CCL2‐binding peptide (WKNFQTI) from murine CCR2 through extracellular loop analysis. Here, higher‐affinity peptide binders are computationally designed through homology modeling and energy calculations, yielding an 11‐amino acid peptide with high binding affinity. In addition, Rosetta mutations improves binding affinity in silico with blockage of the CCL2 dimerization site. Future work in analyzing binding kinetics and in vivo inflammation abrogation will confirm the accuracy of computational modeling techniques in de novo rational design of CCL2 cytokine binders.
Optogenetic Stimulation of mPFC Alleviates White Matter Injury‐Related Cognitive Decline after Chronic Ischemia through Adaptive Myelination
Authors: Deng Shiji , Shu Shu , Zhai Lili , Xia Shengnan , Cao Xiang , Li Huiya , Bao Xinyu , Liu Pinyi , Xu Yun 
Published: December 2022

AbstractWhite matter injury (WMI), which reflects myelin loss, contributes to cognitive decline or dementia caused by cerebral vascular diseases. However, because pharmacological agents specifically for WMI are lacking, novel therapeutic strategies need to be explored. It is recently found that adaptive myelination is required for homeostatic control of brain functions. In this study, adaptive myelination‐related strategies are applied to explore the treatment for ischemic WMI‐related cognitive dysfunction. Here, bilateral carotid artery stenosis (BCAS) is used to model ischemic WMI‐related cognitive impairment and uncover that optogenetic and chemogenetic activation of glutamatergic neurons in the medial prefrontal cortex (mPFC) promote the differentiation of oligodendrocyte precursor cells (OPCs) in the corpus callosum, leading to improvements in myelin repair and working memory. Mechanistically, these neuromodulatory techniques exert a therapeutic effect by inducing the secretion of Wnt2 from activated neuronal axons, which acts on oligodendrocyte precursor cells and drives oligodendrogenesis and myelination. Thus, this study suggests that neuromodulation is a promising strategy for directing myelin repair and cognitive recovery through adaptive myelination in the context of ischemic WMI.
Non‐Fused Ring Acceptors Achieving over 15.6% Efficiency Organic Solar Cell by Long Exciton Diffusion Length of Alloy‐Like Phase and Vertical Phase Separation Induced by Hole Transport Layer
Authors: Luo Dou , Jiang Zhengyan , Tan Wen Liang , Zhang Lifu , Li Lanqing , Shan Chengwei , McNeill Christopher R. , Sonar Prashant , Xu Baomin , Kyaw Aung Ko Ko 
Published: December 2022

AbstractThe construction of high‐performance organic solar cells (OSCs) based on non‐fused ring electron acceptors (NFREAs) is challenging despite their low synthesis complexity and low cost. Herein, highly efficient NFREA‐based OSCs using a ternary approach by blending two in‐house designed NFREAs called “C6C4‐4Cl” and “BTIC‐4F” with the donor PM6 are demonstrated. The two NFREAs with similar molecular skeletons tend to form an alloy‐like phase that exhibits long exciton diffusion lengths and improved crystalline properties for efficient charge transfer. The complementary absorption spectra of the ternary system and energy transfer between the two NFREAs increases the current while the high lowest unoccupied molecular orbital (LUMO) energy level of BTIC‐4F enhances the voltage of the OSCs. As a result, the ternary OSC with two NFREAs yields an impressive power conversion efficiency (PCE) of 15.62% using 2PACz as a hole transporting layer (HTL). Investigation of the buried interface reveals that 2PACz has a strong interaction with PM6 and induces vertical phase separation in the ternary blend. This work provides an effective strategy to improve the performance of NFREA‐based OSCs by increasing the exciton diffusion length in an alloy‐like acceptor phase and inducing vertical phase separation with the judicious selection of HTL.
Improving the Stability of Supercapacitors at High Voltages and High Temperatures by the Implementation of Ethyl Isopropyl Sulfone as Electrolyte Solvent
Authors: Köps Lukas , Kreth Fabian Alexander , Leistenschneider Desirée , Schutjajew Konstantin , Gläßner Rebecka , Oschatz Martin , Balducci Andrea 
Published: December 2022

AbstractTwo of the main weaknesses of modern electric double‐layer capacitors are the rather limited ranges of operating voltage and temperature in which these devices do not suffer from the occurrence of irreversible decomposition processes. These parameters are strongly interconnected and lowering the operating voltage when increasing the temperature is unavoidable, so as to protect the electric double‐layer capacitor from damage. With the aim to maintain the operating voltage as high as possible at elevated temperatures, in this study, the application of ethyl isopropyl sulfone as an electrolyte solvent for electric double‐layer capacitors is presented. It is shown that ethyl isopropyl sulfone‐based electrolytes display excellent thermal and electrochemical stability enabling high capacitance retention after floating tests for 500 h at 60 and 80 °C, e.g. 68% at 3.4 V at 60 °C. A possible reason for the above‐average stability is that decomposition products of ethyl isopropyl sulfone can deposit on the electrode surface which may act as a passivation layer and prevent further degradation.
1,2,4‐Triazole and benzimidazole fused dihydropyrimidine derivatives: Design, green synthesis, antibacterial, antitubercular, and antimalarial activities
Authors: Mokariya Jaydeep A. , Rajani Dhanji P. , Patel Manish P. 
Published: December 2022

AbstractThis study reports the design and synthesis of novel 1,2,4‐triazolo/benzimidazolo‐pyrimidine linked 1‐benzyl‐4‐[(p‐tolyloxy)methyl]‐1,2,3‐triazole derivatives as potent antimicrobial agents according to their in vitro antibacterial, antifungal, antitubercular as well as antimalarial activities. An efficient, ecologically benign, and facile multicomponent synthesis was employed to synthesize these derivatives. The synthesis is accelerated with the mild and eco‐friendly organocatalyst tetrabutylammonium bromide, providing a yield of 82%–96% within the short reaction time of 0.5–1.5 h. Compared with the MIC values of ciprofloxacin and ampicillin on the respective strains, compound d2 showed better activity against Escherichia coli and Streptococcus pyogenes and compound d8 showed better MIC against Staphylococcus aureus. Additionally, compounds d3, d4, and d5 showed potent MIC values against Pseudomonas aeruginosa. All triazolo‐pyrimidine derivatives d1–d8 showed potent inhibitory action against Gram‐positive strains. Compound e3 showed good potency against Mycobacterium tuberculosis H37Rv. The IC50 values of d3 and e2 indicated better activity against Plasmodium falciparum. Collectively, these derivatives depict potent multifaceted activity and provide promising access for further antimicrobial and antimalarial investigations.
Hierarchical Carbon Nanosheet Embedded MnOx Cathode for High‐Performance Aqueous Zinc‐Ion Batteries
Authors: Zhang Shimeng , Wang Xiaoqi , Li Jianbo , Chen Yuwei , Wu Yu , Bai Shengchi , Jin Xu , Jin Bowen , Shao Mingfei 
Published: December 2022

AbstractAqueous zinc‐ion battery is one of the candidates for the next generation batteries due to its reliable safety, environmental friendliness and low cost. While the poor structurally stability and limited cyclic reversibility of the cathode restricts its practical application. In this work, we elaborately design hierarchical three‐dimensional (3D) carbon networks (CNs) for the embedding of non‐stoichiometry MnOx with abundant defects (MnOx/CNs), which provide 3D diffusion pathway and efficient electrochemical active sites for zinc‐ion storage. The as‐designed Zn//MnOx/CNs battery delivers high energy density of 452.2 Wh kg−1 at a power density of 133.0 W kg−1, much superior to that of MnO2/CNs and pristine MnO2. Moreover, defective manganese species experience stable phase transformation during charging/discharging process, providing a long‐term cycling performance with a high reversible capacity of 263.3 mAh g−1 at 1 A g−1 after 1000 cycles.
Three dimensions of thermolabile sex determination
Authors: Waters Paul D. , Graves Jennifer A. Marshall , Whiteley Sarah L. , Georges Arthur , Ruiz‐Herrera Aurora 
Published: December 2022

AbstractThe molecular mechanism of temperature‐dependent sex determination (TSD) is a long‐standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D‐TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity to remodel in response to temperature by changing 3D chromatin conformation, perhaps via temperature‐sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex‐determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex‐determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate.
Systematic review of population‐based bladder cancer registries: How criteria heterogeneity affects the comparison of incidences
Authors: Caballero José María , Gili José María , Pereira Juan Camilo , Gomáriz Alba , Castillo Carlos , Martín‐Baranera Montserrat 
Published: December 2022

AbstractBackgroundThe population‐based registry of bladder cancer (BC) raises specific problems intrinsic to the tumor, as the inclusion of noninfiltrating, potentially malignant and multiple tumors. We performed a systematic review (PRISMA guidelines) of population‐based BC registries to obtain information on their geographic areas involved, last dates of real incidence of BC, and rules coding used in BC for uncertain behavior, in situ and multiple tumors.MethodsUsing MEDLINE and Google Scholar, we identified scientific publications of in the last 10 years in English or Spanish, whether they were related to a national or international cancer registry, provided information on registry rules, and provided data on the incidence of BC.ResultsAfter the first screening, a total of 194 references were obtained. After a second analysis, three registries were selected: International Agency for Research on Cancer (IARC) is a world registry providing real incidence of BC in the period 2008–2012. Surveillance, Epidemiology, and End Results (SEER) Program registered incidence until 2017 in more than 90% of the US population. Spanish Network of Cancer Registries (REDECAN) unifies 14 Spanish registries (27.4% of the population) with real incidence data from 2010 to 2015. The coding and inclusion rules have been modified, but currently, most registries include BC in situ and uncertain behavior tumors. Whenever a new case occurs 36 months after a previous diagnosis, SEER registers those as multiple incident cancers in the same location, while IARC and REDECAN only allow one cancer per location during the lifespan of the patient.ConclusionsComparison of the incidence of BC among different population‐based cancer registries is prone to bias due to the methodological differences regarding the inclusion of carcinomas in situ, indeterminate, and multiple tumors. A good cancer registry could provide better surveillance strategies for BC patients.
RMI2 is a novel prognostic and predictive biomarker for breast cancer
Authors: Zhang Lijie , Hao Chuncheng , Han Baojuan , Zeng Guangchun , Han Lili , Cao Cong , Liu Hui , Zhong Zhenbin , Zhao Xue , Wang Jingxuan , Zhang Qingyuan 
Published: December 2022

AbstractBackgroundRecQ‐mediated genome instability 2 (RMI2) maintains genome stability by promoting DNA damage repair. It has been reported to accelerate the progression of several tumors. However, the functional mechanism of RMI2 in breast cancer remains unclear.MethodsGene expression profiles were obtained from TCGA, GTEx, and GEO databases. The expression of RMI2 and its prognostic value in breast cancer was explored. In addition, we calculated pooled standardized mean deviation (SMD) and performed a summary receiver operating characteristic (sROC) curve analysis to further determine RMI2 expression status and diagnostic significance. The functions and related signaling pathways were investigated based on GO and KEGG analyses. The PPI network was constructed by combining the STRING database and Cytoscape software. Subsequently, in vitro assays were conducted to detect the effect of RMI2 on the proliferation and migration of breast cancer cells.ResultsThe expression of RMI2 was markedly upregulated in breast cancer tissues relative to that in normal tissues. Moreover, pooled SMD further confirmed the overexpression of RMI2 in breast cancer (SMD = 1.29, 95% confidence interval (CI): 1.18–1.41, p = 0.000). The sROC curve analysis result suggested that RMI2 had a relatively high diagnostic ability in breast cancer (AUC = 0.87, 95% CI: 0.84–0.90). High RMI2 expression was associated with poor prognosis. GO and KEGG analyses revealed that RMI2 was closely related to cell adhesion, various enzyme activities, and PI3K/AKT signaling pathway. PPI analysis showed that RMI2 had interactions with proteins involved in DNA damage repair. knockdown of RMI2 remarkably inhibited the proliferation and migration of breast cancer cells, while overexpression of RMI2 exerted the opposite effects. Furthermore, we identified that RMI2 accelerates the proliferation and migration of breast cancer cells via activation of the PI3K/AKT pathway.ConclusionThe results suggest that RMI2 is a potential diagnostic and prognostic biomarker associated with cell proliferation and migration, and may be used as a novel therapeutic target for breast cancer in the future.
Defining the psychiatric and financial burden of mental and substance use disorders in cancer patients
Authors: Baliga Sujith , Klamer Brett , Palmer Joshua D. , Gregirio Sharla Wells‐Di , Kale Sachin S. , Bonomi Marcelo , Old Matthew O. , Rocco James W. , Blakaj Dukagjin M. 
Published: December 2022

AbstractPurposeTo identify the proportion of Emergency Department (ED) visits in cancer patients associated with a mental and substance use disorder (MSUD) and the subsequent healthcare costs.MethodsNationally representative data on ED visits from 2009 to 2018 was obtained from the Nationwide Emergency Department Sample (NEDS). We identified cancer‐related visits with or without a MSUD using the Clinical Classifications Software diagnoses documented during the ED visit. Survey‐adjusted frequencies and proportions of ED visits among adult cancer patients with or without a MSUD was evaluated. Survey‐adjusted multivariable logistic regression models were used to examine demographic and clinical predictors of the presence of an MSUD and the likelihood of hospital admission for patients with a primary MSUD.ResultsAmong 54,004,462 ED visits with a cancer diagnosis between 2009 and 2018, 11,803,966 (22%) were associated with a MSUD. Compared to a primary diagnosis of cancer, patients who presented to the ED with a chief complaint of MSUD were more likely to be female (54% vs. 49%), younger (median: 58 vs. 66), more likely to have Medicaid insurance, and more likely to be discharged home. The three most common MSUD diagnoses among cancer patients were alcohol‐related disorders, anxiety disorders, and depressive disorders. The total costs associated with a primary MSUD from 2009 to 2018 was $3,133,432,103, of which alcohol‐related disorders claimed the largest majority. Younger age (OR per 10‐year increase: 0.86, 95% CI: 0.85, 0.86) and female sex (OR: 1.34, 95% CI: 1.33–1.35) were associated with higher odds of having an MSUD.ConclusionsOur findings demonstrate a high burden of psychiatric and substance use illness in the cancer population and provide the rationale for early psychosocial intervention to support these patients.
Plasma cell myeloma following a prior diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Loyzer Melissa N. , Grewal Kuljit , Ikpatt Offiong Francis 
Published: December 2022

AbstractA 69‐year‐old man presented with plasma cell myeloma (PCM) 4 years after the treatment of chronic lymphocytic leukemia (CLL). Light chain expressions in the two tumors were different suggesting unrelated cell of origin clonality. Few reports have been added to the literature describing synchronous CLL and PCM in a patient.
An Efficient, Site‐Selective and Spontaneous Peptide Macrocyclisation During in vitro Translation
Authors: Liu Minglong , Yoshisada Ryoji , Amedi Avand , Hopstaken Antonius J. P. , Pascha Mirte N. , de Haan Cornelis A. M. , Geerke Daan P. , Poole David A. , Jongkees Seino A. K. 
Published: December 2022

AbstractMacrocyclisation provides a means of stabilising the conformation of peptides, often resulting in improved stability, selectivity, affinity, and cell permeability. In this work, a new approach to peptide macrocyclisation is reported, using a cyanobenzothiazole‐containing amino acid that can be incorporated into peptides by both in vitro translation and solid phase peptide synthesis, meaning it should be applicable to peptide discovery by mRNA display. This cyclisation proceeds rapidly, with minimal by‐products, is selective over other amino acids including nonN‐terminal cysteines, and is compatible with further peptide elaboration exploiting such an additional cysteine in bicyclisation and derivatisation reactions. Molecular dynamics simulations show that the new cyclisation group is likely to influence the peptide conformation as compared to previous thioether‐based approaches, through rigidity and intramolecular aromatic interactions, illustrating their complementarity.
Julia‐Kocienski Olefination: A Tutorial Review
Authors: Sakaine Guna , Leitis Zigmārs , Ločmele Rebeka , Smits Gints 
Published: December 2022

AbstractOver the past two decades, Julia‐Kocienski olefination has become one of the most powerful and reliable C=C double‐bond construction methods typically furnishing E‐configured alkenes. This review summarizes the scientific literature of the past decade focusing on the key aspects for successful execution of the olefination step. The main stereoselectivity and yield‐determining aspects have been outlined in separate chapters providing all the necessary information for the synthesis of Julia‐Kocienski reagents as well as the most commonly used reaction optimization techniques.