bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Activity of Water-alcoholic Extracts of Representatives of the Genus <i>Potentilla</i> L.
Authors: Savelyeva E. E. , Bulgakova N. A. , Lapkina E. Z. , Chernaya V. V. , Kurbatsky V. I. 
Published: November 2022

Introduction. The emerging resistance of bacteria to drugs is one of the serious problems of medicine, which stimulates the constant search for new antimicrobial drugs, also of natural origin. Researchers widely address representatives of various families and genus of the plant world, using various morphological groups of plant raw materials, studying the effect of both the sum of extracted substances and individual compounds.Aim. Investigation of antimicrobial activity of water-alcohol extracts of some representatives of the genus Potentilla in the search for new antimicrobial medicines of plant origin.Materials and methods. The objects of the study were extracts on 40 and 70 % ethyl alcohol from the aboveground part of Potentilla anserinа L., P. erecta (L.) Raeusch, P. argentea L., P. paradoxa Nutt. ex Torr. et Gray, P. goldbachii Rupr., P. approximate Bunge, P. chrysantha Trevir. Antimicrobial activity was determined by diffusion into agar using paper disks. Collection strains of Escherichia coli, Pseudomonas aeruginosa, methicillin-sensitive Staphylococcus aureus (MSSA) and 29 strains of MSSA isolated from biomaterial from patients were used as test cultures. The sensitivity of MSSA strains to antibiotics was characterized by an antibioticogram.Results and discussion. The strain of Escherichia coli turned out to be insensitive to all extracts of the paws. The strain of Pseudomonas aeruginosa is minimally sensitive to extracts of 40 % ethyl alcohol of P. anserinа and P. argentea, to 40 and 70 % extracts of P. approximata. All strains of Staphylococcus aureus (MSSA) are sensitive to all extracts of the paws to varying degrees. Among 40 % of the extracts, the most active are P. anserinа, P. paradoxa and P. erecta extracts, among 70 % of the extracts are P. paradoxa and P. argentea extracts.Conclusion. The studied extracts of seven Potentilla species showed antimicrobial activity against both sensitive and insensitive to antibiotic strains of Staphylococcus aureus (MSSA) to a close or comparable degree, while extracts on 40 % ethyl alcohol are slightly more active compared toextracts on 70 % ethyl alcohol. The results indicate that the studied Potentilla species are promising for further research.
Prognostic and Predictive Significance of mRNA Expression of ABC-transporter Genes in Patients with Non-small Cell Lung Cancer
Authors: Tsyganov M. M. , Ibragimova M. K. , Rodionov E. O. , Frolova A. A. , Miller S. V. , Cheremisina O. V. , Tuzikov S. A. , Litvyakov N. V. 
Published: November 2022

Introduction. To date, one of the reasons for the ineffectiveness of chemotherapy in various malignant neoplasms, including lung cancer, is the formation of the multidrug resistance (MDR) phenotype in tumor cells, which is caused by the expression of ABC transporter genes.Aim. The aim of this work was to assess the expression of ABC-transporter genes during chemotherapy and to analyze the relationship with the effectiveness of chemotherapy and prognosis of the disease.Materials and methods. We used biopsy and surgical material from 91 patients with stage IIB–IIIA non-small cell lung cancer (NSCLC). The treatment regimen included: 2 courses of neoadjuvant chemotherapy (NAC), surgery and 3 courses of adjuvant chemotherapy (ACT) with platinum doublets. RNA was isolated from the samples, followed by quantitative PCR to assess the expression of genes ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2.Results and discussion. It was shown that the level of expression of the studied genes was not associated with the effect of NAC in patients with lung cancer, except for the ABCC5 gene, which showed a relationship at the level of a pronounced trend (p = 0.07). It was also shown that in the group of patients with an objective response to chemotherapy, the frequency of decreased expression of the ABCC1 (p = 0.01) and ABCC5 (p = 0.004) genes was statistically significantly higher than in the group of patients with stabilization. Further, using the Kaplan – Meier method, it was found that a decrease in expression is associated with high rates of metastatic-free survival (MFS). The highest rates of 5-year MFS (more than 85 %) are observed in patients with a decrease in the expression of the ABCB1 and ABCG2 genes, log-rank test p = 0.0007 and p = 0.002, respectively.Conclusion. Thus, it has been shown that changes in the expression of ABC transporter genes are associated with the effectiveness of chemotherapy and the prognosis of the disease. The data obtained can be used as a basis for the detection of potential drug targets.
7747 Numaralı Şe’riyye Siciline Göre Malatya’nın Sosyo-Ekonomik Durumu (1878-1882)
Authors: ULUKAYA Gülşen 
Published: November 2022

er’iyye Sicilleri, sosyal ve ekonomik tarih belgelerini içeren tereke kayıtları yoluyla Osmanlı Devleti tarihi için önemli kaynak olarak görülmektedir. Bu siciller, Osmanlı tarihinin ana kaynakları arasında bulunmaktadır. Bu sicillerde kadının devlet merkeziyle yaptığı yazışmalar, halkın şikâyet ve dilekleri ile en önemlisi sicillerin ait olduğu mahallin sosyal ve ekonomik hayatı hakkında bilgi veren mahkeme kayıtları elde edilmektedir.
Son yıllarda şehir tarihi ile ilgili çok sayıda çalışma yapılmaktadır. Bu çalışmalarda şehrin sosyal yapısı, sosyal münasebetleri, sosyo-kültürel veya sosyo-ekonomik düzeni gibi konular üzerinden genel durumu incelenmektedir. Bu çalışmada başlıkta ifade edildiği gibi 1878-1882 yılları arasında Malatya’nın sosyo-ekonomisi hakkında değerlendirmeler Şer’iyye Sicillerine göre yapılmıştır. Sosyo-ekonomik başlıklı çalışmalar için bazı temel bilgilere; nüfus, iş-meslek, evlilikler, menkul ve gayrı menkul ile fiyatlar hakkında bazı verilere ihtiyaç duyulmaktadır. Osmanlı şehir tarihi çalışmalarında şer’iyye sicillerinde o mahallin sosyo-ekonomik hayatıyla ilgili mühim bilgiler bulunmaktadır. Hususiyetle sicillerdeki tereke kayıtları malumat bakımından zengin bilgiler sunmaktadır. 7747 numaralı Malatya Şer’iyye Sicili (M. 1878-1882) bu çalışmanın ana kaynağıdır.
DESAIN ARSITEKTUR ENTERPRISE SISTEM PEMERITAHAN BERBASIS ELEKTRONIK BIDANG KESEHATAN
Authors: Laksono Agung 
Published: November 2022

Kesehatan menjadi pusat perhatian terutama sejak Covid-19 merebak dan berdampak terhadap berbagai aspek kehidupan masyarakat Indonesia. Layanan Kesehatan diharuskan untuk mampu menyajikan data dan informasi yang cepat dan akurat, sehingga diharapkan strategi penyelesai berbagai tantangan bidang Kesehatan dapat terkendali dan cepat diselesaikan. Transformasi digital menjadi penting karena hanya teknologi informasi yang mampu mendorong pelayanan publik menjadi dapat lebih cepat, adaptif, akurat dan terintegrasi. Perlu adanya perencanaan transformasi digital yang terstruktur dan menyeluruh dapat memberikan pelayanan prima dan adaptif terhadap harapan masyarakat terhadap layanan kesehatan. Tantangannya, palayanan antar satu puskesmas dan lainnya masih berbeda-beda tergantung dari letak geografis dan fasilitas yang dimiliki. Selain itu, variasi aplikasi yang dikembangkan oleh pemerintah pusat mencapai hingga 77 variasi apliasi di tingkat puskesmas sehingga berakibat sulitnya integrasi dan mendukung interoperabilitas antar sistem. Pengembangan teknolog informasi masih bersifat fragmented antar divisi yang berakibat duplikasi entri untuk sistem yang berbeda, data olahan yang redundan, dan sulitnya menjaga konsistensi data.

Penelitian ini bermaksud untuk membuat arsitektur enterprise bidang Kesehatan dengan studi kasus pusdatin Kementerian Kesehatan yang berfokus pada layanan Kesehatan di tingkat puskesmas. Puskesmas merupakan garda terbawah layanan Kesehatan (Kemenkes, 2019) dan telah memiliki regulasi sistem informasi puskesmas (Kemenkes, 2021) yang seharusnya dapat mendorong peningkatan optimasasi penggunaan teknologi informasi di tingkat puskesmas yang terintegrasi hingga pusat. Harapannya penelitian ini dapat menyajikan grand design pengelolaan teknologi informasi berbasis industry 4.0 yang efektif dan sesuai dengan regulasi yang berlaku. Penelitian akan berfokus pada pengembangan arsitektur enterprise dengan mempertimbangkan kebijakan Sistem Pemerintahan Berbasis Elektronik (SPBE).

Metode perancangan arsitektur dikembangkan menggunakan kerangka kerja TOGAF ADM untuk menganalisis arsitektur sistem. Studi ini merancang arsitektur pada tingkat kementerian sebagai turunan dari arsitektur induk serta menyelaraskan dengan arsitektur daerah. Analisa didukung dengan mempertimbangkan kesesuaian regulasi SPBE, regulasi Meteri Kesehatan, rencana strategis jangka Menengah, dan peta jalan digital transformasi Kementerian Kesehatan. Hasil analisis akan disajikan dalam gap analysis yang membandingkan kondisi saat ini dan target arsitektur ingin dicapai. Rancangan ini diharapkan dapat memberikan usulan arsitektur enterprise dalam imlementasi Sistem Pemerintahan Berbasis Elektronik pada Kementerian Kesehatan. Selain itu, studi ini juga dapat menjadi referensi untuk desain arsitektur enterprise dengan metodologi TOGAF ADM dan pengembangan berbasis SPBE.
Sex differences in coronary artery bypass grafting-related morbidity and mortality
Authors: Nurkkala Jouko , Kauko Anni , Palmu Joonatan , Aittokallio Jenni , Niiranen Teemu 
Published: November 2022

BackgroundCoronary artery bypass grafting (CABG) is associated with both cardiovascular disease (CVD) and non-CVD traits. In addition, women’s prognosis after coronary events and revascularizations is worse than in men. As the course of CVD in women differs from that of men, we performed a phenome-wide analysis on the sex differences in CABG -related morbidity and mortality.Materials and methodsWe performed an untargeted analysis on the sex differences in predictors and outcomes of CABG. We studied a sample of 176,680 FinnGen participants, including 5,950 individuals who underwent CABG (4,988 men and 962 women) and were followed between 1998 and 2019. Over 1,100 different traits were analyzed for both sexes and the results were adjusted with age, smoking status and BMI. Cox proportional hazards models with sex-trait interactions were used to estimate the associations between (1) traits and incident CABG; and (2) CABG and incident traits.ResultsIn women, CABG was more strongly related to greater increases in risk of diseases such as hypertension, Alzheimer’s, aortic aneurysms, gout, and chronic kidney disease compared to risk increases observed in men (all interaction p-values &lt; 0.03). After CABG, men had 2.5-fold (p = 3.1E−15) and women 6.3-fold (p = 9.4E−08) greater risk of cardiac death compared to same-sex individuals who did not undergo CABG (p for interaction 8.2E−4). Moreover, the risk of death in women remained higher even 12 years after CABG, whereas the long-term risk of death in men was not increased, compared to same-sex individuals who did not undergo CABG.ConclusionThe adverse outcomes after CABG, both quantity and quality, also appear to differ between men and women. In women, CABG is related to greater long-term increases in risk of cardiac death and several other disease states than in men. Consideration should therefore be given to whether women receive adequate long-term post-operative therapy and follow-up as CABG is not associated with equally improved cardiovascular disease prognosis in women than in men.
The atrial secondary tricuspid regurgitation is associated to more favorable outcome than the ventricular phenotype
Authors: Gavazzoni Mara , Heilbron Francesca , Badano Luigi P. , Radu Noela , Cascella Andrea , Tomaselli Michele , Perelli Francesco , Caravita Sergio , Baratto Claudia , Parati Gianfranco , Muraru Denisa 
Published: November 2022

AimWe sought to evaluate the differences in prognosis between the atrial (A-STR) and the ventricular (V-STR) phenotypes of secondary tricuspid regurgitation.Materials and methodsConsecutive patients with moderate or severe STR referred for echocardiography were enrolled. A-STR and V-STR were defined according to the last ACC/AHA guidelines criteria. The primary endpoint was the composite of all-cause death and heart failure (HF) hospitalizations.ResultsA total of 211 patients were enrolled. The prevalence of A-STR in our cohort was 26%. Patients with A- STR were significantly older and with lower NYHA functional class than V-STR patients. The prevalence of severe STR was similar (28% in A-STR vs. 37% in V-STR, p = 0.291). A-STR patients had smaller tenting height (TH) (10 ± 4 mm vs. 12 ± 7 mm, p = 0.023), larger end-diastolic tricuspid annulus area (9 ± 2 cm2 vs. 7 ± 6 cm2/m2, p = 0.007), smaller right ventricular (RV) end-diastolic volumes (72 ± 27 ml/m2 vs. 92 ± 38 ml/m2; p = 0.001), and better RV longitudinal function (18 ± 7 mm vs. 16 ± 6 mm; p = 0.126 for TAPSE, and −21 ± 5% vs. −18 ± 5%; p = 0.006, for RV free-wall longitudinal strain, RVFWLS) than V-STR patients. Conversely, RV ejection fraction (RVEF, 48 ± 10% vs. 46 ± 11%, p = 0.257) and maximal right atrial volumes (64 ± 38 ml/m2 vs. 55 ± 23 ml/m2, p = 0.327) were similar between the two groups. After a median follow-up of 10 months, patients with V-STR had a 2.7-fold higher risk (HR: 2.7, 95% CI 95% = 1.3–5.7) of experiencing the combined endpoint than A-STR patients. The factors related to outcomes resulted different between the two STR phenotypes: TR-severity (HR: 5.8, CI 95% = 1, 4–25, P = 0.019) in A-STR patients; TR severity (HR 2.9, 95% CI 1.4–6.3, p = 0.005), RVEF (HR: 0.97, 95% CI 0.94–0.99, p = 0.044), and RVFWLS (HR: 0.93, 95% CI 0.85–0.98, p = 0.009) in V-STR.ConclusionAlmost one-third of patients referred to the echocardiography laboratory for significant STR have A-STR. A-STR patients had a lower incidence of the combined endpoint than V-STR patients. Moreover, while TR severity was the only independent factor associated to outcome in A-STR patients, TR severity and RV function were independently associated with outcome in V-STR patients.
Hypothermia and its role in patients with ST-segment-elevation myocardial infarction and cardiac arrest
Authors: Keller Karsten , Sagoschen Ingo , Schmitt Volker H. , Münzel Thomas , Gori Tommaso , Hobohm Lukas 
Published: November 2022

BackgroundPatients suffering cardiac arrest resulting from ST-segment-elevation myocardial infarction (STEMI) are at very high risk of death. In addition to reperfusion strategies, therapeutic hypothermia is recommended for cardiac arrest patients who remain unconscious after resuscitation. However, data analysis of the impact of therapeutic hypothermia on survival showed inconsistent results. We aimed to investigate the benefits of therapeutic hypothermia in STEMI patients after cardiopulmonary resuscitation (CPR).MethodsPatients with STEMI who received CPR were identified after nationwide German inpatient data (2005–2019) were screened. These patients were stratified for therapeutic hypothermia. The impact of hypothermia on mortality and adverse in-hospital outcomes was analyzed.ResultsOverall, 133,070 inpatients with STEMI and CPR (53.3% aged ≥70 years; 34% females) were recorded in Germany between 2005 and 2019, of which 12.3% (16,386 patients) underwent therapeutic hypothermia. Females (23.8 vs. 35.4%, p &lt; 0.001) and patients aged ≥70 years (34.9 vs. 55.9%, p &lt; 0.001) were less frequently treated with therapeutic hypothermia. The in-hospital case fatality rate was lower for STEMI with CPR and subsequent therapeutic hypothermia than for treatment without therapeutic hypothermia (53.5 vs. 66.7%, p &lt; 0.001). Therapeutic hypothermia was independently associated with a reduced in-hospital case fatality rate {OR 0.83 [95% confidence interval (CI) 0.80–0.86], p &lt; 0.001}. In addition, therapeutic hypothermia was associated with an increased risk for stroke (OR 1.37 [95% CI 1.25–1.49], p &lt; 0.001), pneumonia (OR 1.75 [95% CI 1.68–1.82], p &lt; 0.001), and acute kidney injury (OR 2.21 [95% CI 2.07–2.35], p &lt; 0.001).ConclusionTherapeutic hypothermia is associated with a survival benefit for STEMI patients after cardiac arrest.
The treatment choices of abdominal aortic aneurysm patients in China in the era of value-based healthcare
Authors: Duan Liren , Xin Wei , Li Shenli , Zhao Lin , Xin Shijie 
Published: November 2022

BackgroundEndovascular aneurysm repair (EVAR) is often seen as the first choice treatment for patients with abdominal aortic aneurysm (AAA), particularly high-risk patients, yet the long-term survival rate and improvement in quality of life are still unclear. In order to seek the value of EVAR to the entire healthcare field, we conducted a retrospective study to evaluate whether the improvement EVAR can truly bring to the quality of medical care in the era of value-based healthcare.MethodsWe included AAA patients who underwent surgical treatment in the Department of Vascular Surgery, First Hospital of China Medical University, from January 1, 2004, to December 31, 2019 and evaluated surgery procedure data, short-term and long-term mortality, complications, prognoses, and medical costs.ResultsWe analyzed 507 patients with AAA who underwent open repair (n = 232) or EVAR (n = 275) over a 15-year period. The operative time, blood loss, blood transfusion rate, and postoperative length of hospital stay of the EVAR group is significantly lower than which of the open repair group. Meanwhile, neither short-term nor long-term mortality rates shows significant differences between the two groups. On the other hand, the complication rate of the EVAR group was significantly higher than that of the open repair group. Lastly, the total cost of EVAR was significantly higher than that of open repair.ConclusionExisting evidence suggests that EVAR improves neither short-term nor long-term survival rate compared with open surgery. In contrast, the complication rate and the reintervention rate in the EVAR group were higher than those in the open surgery group. Moreover, the cost of EVAR and that paid by medical insurance were higher than those for open surgery. For patients with a long-life expectancy, in order to ensure that patients receive appropriate and effective care, surgeons should choose a suitable method that considers both the quality of medical care as well as the expense accordingly.
Dynamics of price competition in Italian pharmaceutical off-patent market
Authors: Perna Serena , Cangini Agnese , Marini Roberto , Guerrizio Maria Alessandra , Da Cas Roberto , Traversa Giuseppe , Trotta Francesco 
Published: November 2022

IntroductionThe aim of the study was to evaluate, in a regulated generics market, the effect of the number of manufacturers of generic drugs on the amplitude of off-patent products price reduction and the price evolution of originators and generics after the patent expiry of pharmaceuticals dispensed by community pharmacies and reimbursed by the Italian National Health Service (INHS).MethodsThe AIFA “transparency list” was utilized to select unbranded and branded off-patent drug dispensed by community pharmacies and reimbursed by the Italian National Health Service between 2012 and 2018. The unbranded drug entry in the transparency list database was considered as a proxy of its patent expiry.ResultsA total of 42 different active ingredients were included in the analysis. The relative price per dose at time t of unbranded and branded drugs, considering as common denominator the price per dose a year before the patent expiry, (t-1) decreased with the increase of unbranded manufacturers. At the time of the patent expiry, the price of unbranded drugs was almost 50% less than that of branded drugs at t-1 and the price of branded drugs started to decrease before the first unbranded entry.ConclusionAn inverse relation between the number of generic drug entrants and the price of generics and originators was detected. The patent expiry determines a price decline, more concentrated in the first year of patent expiry.
Costs and effects of telerehabilitation in neurological and cardiological diseases: A systematic review
Authors: Del Pino Rocio , Díez-Cirarda Maria , Ustarroz-Aguirre Iker , Gonzalez-Larragan Susana , Caprino Massimo , Busnatu Stefan , Gand Kai , Schlieter Hannes , Gabilondo Iñigo , Gómez-Esteban Juan Carlos 
Published: November 2022

IntroductionTelerehabilitation in neurological and cardiological diseases is an alternative rehabilitation that improves the quality of life and health conditions of patients and enhances the accessibility to health care. However, despite the reported benefits of telerehabilitation, it is necessary to study its impact on the healthcare system.MethodsThe systematic review aims to investigate the costs and results of telerehabilitation in neurological and cardiological diseases. MEDLINE and EMBASE databases were searched from 2005 to 2021, for studies that assess the costs and results of telerehabilitation compared to traditional rehabilitation (center-based programs) in neurological and cardiological diseases. A narrative synthesis of results was carried out.ResultsA total of 8 studies (865 participants) of 430 records were included. Three studies were related to the costs and results of telerehabilitation in neurological diseases (specifically in stroke). In total, five studies assessed telerehabilitation in cardiological diseases (chronic heart failure, coronary heart disease, acute coronary syndrome, and cardiovascular diseases). The duration of the telerehabilitation ranged from 6 to 48 weeks. The studies included cost-analysis, cost-benefit, cost-effectiveness, or cost-utility. In total, four studies found significant cost/savings per person between $565.66 and $2,352.00 (p &lt; 0.05). In contrast, most studies found differences in costs and clinical effects between the telerehabilitation performed and the rehabilitation performed at the clinic. Just one study found quality-adjusted life years (QALY) significant differences between groups [Incremental cost-effectiveness ratio (ICER) per QALY ($−21,666.41/QALY).DiscussionTelerehabilitation is an excellent alternative to traditional center rehabilitation, which increases the accessibility to rehabilitation to more people, either due to the geographical situation of the patients or the limitations of the health systems. Telerehabilitation seems to be as clinical and cost-effective as traditional rehabilitation, even if, generally, telerehabilitation is less costly. More research is needed to evaluate health-related quality of life and cost-effectiveness in other neurological diseases.Systematic review registration[https://figshare.com/articles/journal_ contribution/Review_Protocol_Costs_and_effects_of_Telerehabilitation_in_ Neurological_and_Cardiological_Diseases_A_Systematic_Review/19619838], identifier [19619838].