bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells
Authors: Vacchini Alessandro , Yang Qinmei , Chancellor Andrew , Spagnuolo Julian , Joss Daniel , Øyås Ove , Beshirova Aisha , De Gregorio Corinne , Pfeffer Michael , Stelling Jörg , Häussinger Daniel , Lepore Marco , Mori Lucia , De Libero Gennaro 
Published: August 2022

SummaryMR1T lymphocytes are a recently identified population of T cells that recognize unknown self-antigens presented by the non-polymorphic MHC-I-related molecule, MR1. MR1T cells can kill tumor cells and modulate the functions of other immune cells with promising therapeutic applications. By integrating genetic, pharmacological and biochemical approaches we identified carbonyl stress and alterations of nucleobase metabolism in tumor target cells that promote recognition by MR1 T cells. We dissected these pathways and found that nucleobase adduct-containing metabolites are self-antigens stimulating MR1T cells. Several nucleobase adducts are presented by MR1 molecules and stimulate individual MR1T cells. Our data suggest that MR1T cells are surveyor of cellular metabolic alterations occurring in conditions of metabolic stress, such as cancer, and lay the groundwork for the development of novel HLA-unrestricted T cell-based therapies.
Membrane Tethering of SepF, a Membrane Anchor for the Mycobacterium tuberculosis Z-ring
Authors: Dey Souvik , Zhou Huan-Xiang 
Published: August 2022

AbstractBacterial cell division begins with the formation of the Z-ring via polymerization of FtsZ and the localization of Z-ring beneath the inner membrane through membrane anchors. In Mycobacterium tuberculosis (Mtb), SepF is one such membrane anchor, but our understanding of the underlying mechanism is very limited. Here we used molecular dynamics simulations to characterize how SepF itself, a water-soluble protein, tethers to acidic membranes that mimic the Mtb inner membrane. In addition to an amphipathic helix (residues 1-12) at the N-terminus, membrane binding also occurs through two stretches of positively charged residues (Arg27-Arg 37 and Arg95-Arg107) in the long linker preceding the FtsZ-binding core domain (residues 128-218). The additional interactions via the disordered linker stabilize the membrane tethering of SepF, and keep the core domain of SepF and hence the attached Z-ring close to the membrane. The resulting membrane proximity of the Z-ring in turn enables its interactions with and thus recruitment of two membrane proteins, FtsW and CrgA, at the late stage of cell division.
Initial development of tandem wing UAV aerodynamic configuration
Authors: Kostić Ivan , Tanović Dragoljub , Kostić Olivera , Abubaker Ahmed Ali Irhayim , Simonović Aleksandar 
Published: August 2022

Purpose
Unmanned aerial vehicles (UAV) with remote and/or automated flight and mission controls have replaced airplanes with pilots in many important roles. This study aims to deal with computational fluid dynamics (CFD) analysis and development of the aerodynamic configuration of a multi-purpose UAV for low and medium altitudes. The main aerodynamic requirement was the application of the tandem wing (TW) concept, where both wings generate a positive lift and act as primary lifting devices.

Design/methodology/approach
Initial design analyses of the UAV’s aerodynamic configuration were performed using ANSYS Fluent. In previous work in Fluent, the authors established a calculation model that has been verified by experiments and, with minor adjustments, could be applied for subsonic, transonic and supersonic flow analyses.

Findings
The design evolved through eight development configurations, where the latest V8 satisfied all the posted longitudinal aerodynamic requirements. Both wings generate a substantial amount of positive lift, whereas the initial stall occurs first on the front wing, generating a natural nose-down stall recovery tendency. In the cruising flight regime, this configuration has the desired range of longitudinal static stability and its centre of pressure is in close proximity to the centre of gravity.

Practical implications
The intermediate development version V8 with proper longitudinal aerodynamic characteristics presents a good starting point for future development steps that will involve the optimization of lateral-directional aerodynamics.

Originality/value
Using contemporary CFD tools, a novel and original TW aerodynamic configuration have evolved within eight development stages, not being based on or derived from any existing designs.
A combination method for integrated modular avionics safety analysis
Authors: Yang Haiyun , Sun Youchao 
Published: August 2022

Purpose
This study aims to solve the problem that the traditional hierarchically performed hazard origin and propagation studies (HiP-HOPS) cannot make dynamic model for the complex system such as integrated modular avionics (IMA) system.

Design/methodology/approach
A new combination method that combines HiP-HOPS with architecture analysis and design language (AADL) is proposed.

Findings
The combination method potentially reduces the amount of rework required for safety analysis and modelling of a modified design.

Research limitations/implications
Modelling the IMA system with the combination method can just make qualitative analysis but cannot make quantitative analysis.

Practical implications
The static model depicts the fault propagation among the components while the dynamic model describes the composite fault with AADL for IMA system.

Originality/value
The results of the case study show that the proposed method not only keeps model consistency but also makes safety analysis and modelling for IMA system efficiently.
Bilateral and multilateral aid perspectives of economic growth in sub-Saharan Africa
Authors: Edo Samson , Matthew Oluwatoyin , Ogunrinola Ifeoluwa 
Published: August 2022

PurposeThe purpose of this study is to determine the impact of disaggregate official development aid (ODA) on economic growth, and ascertain whether bilateral and multilateral aid played complementary role with private sector, government sector and external sector in driving growth of sub-Saharan African economies.Design/methodology/approachThe role of bilateral and multilateral aid in economic growth of sub-Saharan Africa (SSA) is investigated in this study. The vector error correction model (VECM) and generalized method of moments (GMM) techniques are employed in estimating the short-run and long-run impacts, over the period 1980–2020.FindingsThe estimation results reveal that the effect of bilateral aid is positive, and more significant than multilateral aid. Their effect on economic growth is, however, less significant than the effects of domestic private investment and government spending. Nonetheless, aid complemented private and government sectors in facilitating growth. External trade is the only exogenous variable in estimation that is insignificant. The results further reveal that economic growth is unable to significantly respond to its own lag. Generally, the estimation results conform to theoretical expectations.Practical implicationsOne major implication of the findings is that SSA countries have benefited substantially from development aid. It is, therefore, important for these countries to develop stronger institutions that would attract more inflows of development aid.Originality/valueThe study was motivated by the fact that less attention has been given to the role of disaggregate ODA in economic growth of African countries. Previous research works have tended to focus more on aggregate ODA. Furthermore, adequate research has yet to be done on how ODA complements the private sector, government sector and external sector in facilitating growth of African countries. These issues are investigated in the study.
Reviewing topics of COVID-19 news articles: case study of CNN and China daily
Authors: Yuan Yue , Liu Kan , Wang Yanli 
Published: August 2022

PurposeThe purpose of this study is to analyze the topics of COVID-19 news articles for better obtaining the relationship among and the evolution of news topics, helping to manage the infodemic from a quantified perspective.Design/methodology/approachTo analyze COVID-19 news articles explicitly, this paper proposes a prism architecture. Based on epidemic-related news on China Daily and CNN, this paper identifies the topics of the two news agencies, elucidates the relationship between and amongst these topics, tracks topic changes as the epidemic progresses and presents the results visually and compellingly.FindingsThe analysis results show that CNN has a more concentrated distribution of topics than China Daily, with the former focusing on government-related information, and the latter on medical. Besides, the pandemic has had a big impact on CNN and China Daily's reporting preference. The evolution analysis of news topics indicates that the dynamic changes of topics have a strong relationship with the pandemic process.Originality/valueThis paper offers novel perspectives to review the topics of COVID-19 news articles and provide new understandings of news articles during the initial outbreak. The analysis results expand the scope of infodemic-related studies.
Consumer willingness to pay for traceable food products: a scoping review
Authors: Vriezen Rachael , Plishka Mikayla , Cranfield John 
Published: August 2022

PurposeTraceability is an increasingly important tool for reducing food safety risks and managing supply logistics. Given the costs of implementing and maintaining traceability systems, it is crucial to understand consumer willingness to pay (WTP) for traceable products.Design/methodology/approachThe authors conducted a scoping review to collate the existing literature on consumer WTP for traceability in food products to determine the nature of the evidence base and to identify research gaps.FindingsA total of 77 articles were included in the review. The number of studies published per year generally increased over the review period, and China and the United States were the most common countries in which studies were conducted (43.6 and 14.1% of total studies, respectively). All but one of the studies investigated at least one factor that might influence consumer WTP for traceability, the most common of which was socio-demographic characteristics (72.7%). Three-quarters of studies used hypothetical methods to elicit WTP values (75.3%), whereas one-quarter used non-hypothetical methods (24.7%). Most studies included some measure of preference heterogeneity (83.1%).Research limitations/implicationsThere is some potential for systematic bias in the evidence due to the predominance of studies from only a few countries and the possible presence of hypothetical bias. These potential biases could be corrected through future research.Originality/valueTo the authors’ knowledge, no previous study systematically and comprehensively identifies and summarizes the evidence base on consumer WTP for traceable food products.
The influence of technostress on the intention to use blockchain technology: the perspectives of Jordanian auditors
Authors: Alshurafat Hashem , Al-Mawali Hamzah , Al Shbail Mohannad Obeid 
Published: August 2022

Purpose
Blockchain technology is an indispensable solution for all professionals. However, auditors have not been adequately prepared to use blockchain technology. This study aims to examine the impact of technostress on auditors’ acceptance to use blockchain technology.

Design/methodology/approach
A model combining the technostress and factors from the technology acceptance model is proposed. Data were obtained from 142 auditors in the Big 4 and non-Big 4 firms through previously tested and validated questionnaires.

Findings
As hypothesized, the results show that technostress influences the perceived usefulness and ease of use of blockchain technology. This study finds that perceived ease of use and perceived usefulness are significant predictors of attitudes toward use decisions, while the latter is a significant predictor of behavioral intention to use blockchain technology. The results are valuable to accountants, auditors and audit firm managers.

Originality/value
This paper provides empirical evidence on the impact of technostress on auditor acceptance to use blockchain technology, which is deemed as a debate viewpoint.
Assessing the value of 3G and 4G network modes in mobile phone pricing
Authors: Ahmed Tanvir , Ahmad Waseem , Ahmad Bashir 
Published: August 2022

PurposeMobile phone network third-generation (3G) and fourth-generation (4G) modes are the most commonly used modes in many developing countries. This study aims to assess the impact of these network modes and other mobile phone attributes on their retail prices in Pakistan, the fifth most populous and developing country.Design/methodology/approachThis study has been conducted in Punjab province, which shares about 53% of the Pakistan’s population. Hedonic price analysis was carried out on all new mobile phone attributes sold in Punjab’s markets at the retail level. Various econometric tests, that is, Ramsey regression equation specification error, Breusch–Pagan/Cook–Weisberg and variance inflation factor, were calculated to check the robustness of the results.FindingsResults of this study indicated that the mobile phone prices were significantly higher for the sets having 4G network mode than the 3G mode. In addition to this, other mobile phone attributes that significantly influenced their prices were brand, weight, camera, random access memory (RAM), memory size, operating system, battery capacity and display size.Research limitations/implicationsThis study has implications for mobile phone sales and marketing strategies of the manufacturers, importers, retailers and others involved in the mobile phone business in developing countries like Pakistan. Mobile phone manufacturers/importers can increase their profits by producing/importing the 4G enabled devices.Originality/valueAlthough many studies in the literature estimated the implicit price of mobile phone attributes, none of these had explicitly assessed the impact of network mode generation of mobile phones on their prices.
Probabilistic method for impact load estimation by Stochastic Model – a Fan Blade Off event
Authors: Narayanan Govindarajan 
Published: August 2022

PurposeThe front bearing mount structure in an aero engine has been severely loaded under the fan blade off (FBO) event since imbalance forces at high amplitude but low frequency is transformed to the engine front mount structure. The bearing mount structural forces are estimated by an integrated implicit-explicit analysis process of whole engine model of an aero engine. Since there are many dependent factors which are governing those predicted loads, experimental evidence on FBO is becoming necessary to validate the model used for the load prediction which is more expensive and also time consuming. This paper aims to discuss the above mentioned issues.Design/methodology/approachThe current paper deals with the high impact but low probability nature of FBO load prediction on the bearing mount structure by stochastic approach which could be replaced for FBO experiments which is highly essential for current economic conditions. Several influential factors on the predicted loads have been chosen in the stochastic model and sensitive analysis has also been performed to bring down the variation involved in the predicted load.FindingsThe predicted load by proposed stochastic model is then compared with the experimental results. The conclusion on the predicted load with various dependent influential factors is matching well with certain value of damage factor from planned FBO test event.Research limitations/implicationsLimitation of this paper could be that it does not cover with range of load amplitude and is only applicable for civil small and medium engines.Practical implicationsThe high amplitude but low frequency load pattern is assessed with impact condition by stochastic model.Originality/valueCombining experimental and probabilistic load prediction was never done before and read across from previous engine test program could be effectively performed with stochastic model approach.
Development of a faculty satisfaction questionnaire for Ecuadorian higher institutions
Authors: Estrada Aguilar Leonardo Mario , Yoong Parraga Cristina Edith , Bustamante Gracia Karen Stefanie 
Published: August 2022

PurposeThe purpose of this paper is to develop and validate a context-specific scale to assess faculty job satisfaction for Ecuadorian higher education institutions.Design/methodology/approachA draft questionnaire was developed after reviewing the literature. Then, following a pilot study the questionnaire was administered to a stratified random sample of 261 faculty members of an Ecuadorian University. An exploratory factor analysis based on a pairwise polychoric correlation matrix was carried out to validate the scale.FindingsA 24-item faculty satisfaction questionnaire was developed. The scale showed high reliability and validity. Following an exploratory factor analysis five dimensions emerged: 1) rewards and benefits, 2) IT and facilities services, 3) administrative and other campus services, 4) teaching support and development and 5) working relationships.Research limitations/implicationsAlthough our sample size is considered good, the ratio subjects to items of 6:1 was just above the recommended minimum. Due to the split questionnaire design for the research support and community services support sections and the fact that more than a half of the participants did not fill them we had to exclude the items from those sections from the analysis.Practical implicationsThe scale can be used by higher education institutions to assess faculty satisfaction periodically.Originality/valueTo our knowledge this is the first study to develop a context-specific instrument to measure job satisfaction in Ecuadorian higher education institutions using exploratory factor analysis.
How do women entrepreneurs influence the strategic orientation of family businesses? A typology of Swedish decision-making in Småland community
Authors: Gashi Nulleshi Shqipe 
Published: August 2022

Purpose
This paper aims to add to the theorization of family dynamics and women’s entrepreneurship by examining women’s influence on decision-making in family businesses. Business decisions in family firms, in particular, are not free from family influence in terms of goals and strategies, and the role of women in decision-making processes is of particular interest. Consequently, the role of women entrepreneurs in family firms and their influence on business development requires a more fine-grained analysis of the family dynamic within the family and the business.

Design/methodology/approach
This study draws on a qualitative study and focuses on the life story narratives of nine women in rural family businesses in rural communities of Småland province in Sweden to empirically examine the decision-making processes. This region is known both for its entrepreneurial culture and traditional gender order. Based on the narrative accounts of women entrepreneurs in family businesses, the data analysis method is thematic, using a Gioia-inspired method.

Findings
The complexity of decision-making in rural family firms is further complicated in part due to a closeness with the rural community. Thus, a typology of three decision-making modes in family firms emerges an informal family-oriented mode, a semistructured family/employee consensus mode and a formal board mode with at least one nonfamily member. Moreover, the advantages, disadvantages and strategies that women use to influence decisions within the respective mode are outlined.

Originality/value
This work contributes to the study of women’s agency and its implications in family business and entrepreneurship in the rural context. The study implies that women’s agency shapes the (rural) entrepreneurship context and, likewise, the (rural) entrepreneurship context influences women’s agency. Hence, the author challenges the view of women as only caregivers and sheds light on the practices and processes behind the scenes of entrepreneurial family businesses.
Trade effects of a negative export shock on direct exporters and wholesalers
Authors: Juust Mathias 
Published: August 2022

PurposeThis paper aims to investigate the effects of a multifaceted negative Russian export shock of 2014 on the exports Estonian firms that exported non-embargoed goods to Russia.Design/methodology/approachThe dataset covers all the Estonian exporters that exported non-embargoed goods to Russia in 2013 and the empirical analysis uses a difference-in-difference method in combination with the coarsened exact matching method to account for heterogeneities between the treatment and control groups.FindingsThe empirical findings show that wholesalers affected were generally able to show better export performance after the negative shock than direct exporters were. The trade performance after the shock was lower for both wholesalers and direct exporters that had lower initial productivity levels.Originality/valueAs a novelty, this study simultaneously addresses several firm heterogeneities to illustrate how the trade effects of a negative export shock differ between firms with different key characteristics, including between wholesalers and direct exporters.
Financial inclusion washing
Authors: Ozili Peterson K. 
Published: August 2022

Purpose
Financial inclusion washing has not been considered to be a crime although it should be. This paper aims to present a discussion about financial inclusion washing. It was argued that financial inclusion washing is the deliberate or unintentional use of exaggerated claims or misleading claims to describe an entity’s commitment to increase the level of financial inclusion.

Design/methodology/approach
This paper used the conceptual discourse analysis methodology.

Findings
This paper showed that many entities are at risk of practicing financial inclusion washing such as international development organizations, aid organizations, government agencies, central banks, financial institutions, financial inclusion support groups and associations, among others. This paper also highlighted the manifestations, motivations and consequences of financial inclusion washing. This paper also identified ways through which entities can avoid financial inclusion washing.

Originality/value
The literature has not examined how exaggerated claims about financial inclusion efforts mislead people.