bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural quantum reservoir computing for temporal information processing
Authors: Suzuki Yudai , Gao Qi , Pradel Ken C. , Yasuoka Kenji , Yamamoto Naoki 
Published: January 2022

AbstractReservoir computing is a temporal information processing system that exploits artificial or physical dissipative dynamics to learn a dynamical system and generate the target time-series. This paper proposes the use of real superconducting quantum computing devices as the reservoir, where the dissipative property is served by the natural noise added to the quantum bits. The performance of this natural quantum reservoir is demonstrated in a benchmark time-series regression problem and a practical problem classifying different objects based on temporal sensor data. In both cases the proposed reservoir computer shows a higher performance than a linear regression or classification model. The results indicate that a noisy quantum device potentially functions as a reservoir computer, and notably, the quantum noise, which is undesirable in the conventional quantum computation, can be used as a rich computation resource.
Road traffic and landscape characteristics predict the occurrence of native halophytes on roadside verges
Authors: Fekete R. , Bak H. , Vincze O. , Süveges K. , Molnár V. A. 
Published: January 2022

AbstractRoad management practices, such as winter de-icing create ideal habitats and competitive advantage for salt-tolerant species. We aimed to map the occurrences of halophytes along roads in Hungary. Furthermore, we tested factors that might play a role in the roadside occurrences of five chosen native halophytes from rare to common, we encountered during our field surveys. These were Festuca pseudovina, Limonium gmelinii subsp. hungaricum, Podospermum canum, Puccinellia distans and Spergularia media. We found, that at least one halophyte species was documented in 71% of the total sampling points. Germination experiments indicated that substrate salt concentration significantly decreased germination rates in each of the five species, but in case of L. gmelinii subsp. hungaricum, or P. distans germination occurred on extremely high salt concentrations. Traffic intensity, the presence of other halophytes at the sampling point and the presence of a given species in the surrounding landscape had a significant positive effect on the occurrence of four of the five model species. Our results suggest that the studied species are mostly in the early stage of their roadside spread, colonizing roadsides close to their native distribution ranges. The possibility of a future range expansion along roads cannot be excluded.
Assessment of fluid unresponsiveness guided by lung ultrasound in abdominal surgery: a prospective cohort study
Authors: Bar Stéphane , Yee Céline , Lichtenstein Daniel , Sellier Magali , Leviel Florent , Abou Arab Osama , Marc Julien , Miclo Matthieu , Dupont Hervé , Lorne Emmanuel 
Published: January 2022

AbstractA fluid challenge can generate an infraclinical interstitial syndrome that may be detected by the appearance of B-lines by lung ultrasound. Our objective was to evaluate the appearance of B-lines as a diagnostic marker of preload unresponsiveness and postoperative complications in the operating theater. We conducted a prospective, bicentric, observational study. Adult patients undergoing abdominal surgery were included. Stroke volume (SV) was determined before and after a fluid challenge with 250 mL crystalloids (Delta-SV) using esophageal Doppler monitoring. Responders were defined by an increase of Delta-SV > 10% after fluid challenge. B-lines were collected at four bilateral predefined zones (right and left anterior and lateral). Delta-B-line was defined as the number of newly appearing B-lines after a fluid challenge. Postoperative pulmonary complications were prospectively recorded according to European guidelines. In total, 197 patients were analyzed. After a first fluid challenge, 67% of patients were responders and 33% were non-responders. Delta-B-line was significantly higher in non-responders than responders [4 (2–7) vs 1 (0–3), p < 0.0001]. Delta-B-line was able to diagnose fluid non-responders with an area under the curve of 0.74 (95% CI 0.67–0.80, p < 0.0001). The best threshold was two B-lines with a sensitivity of 80% and a specificity of 57%. The final Delta-B-line could predict postoperative pulmonary complications with an area under the curve of 0.74 (95% CI 0.67–0.80, p = 0.0004). Delta-B-line of two or more detected in four lung ultrasound zones can be considered to be a marker of preload unresponsiveness after a fluid challenge in abdominal surgery.The objectives and procedures of the study were registered at Clinicaltrials.gov (NCT03502460; Principal investigator: Stéphane BAR, date of registration: April 18, 2018).
The impact of FFP3 respirators on the blood saturation
Authors: Wojtasz Izabela , Jaracz Krystyna , Sobczyński Paweł , Drużdż Artur , Dyk Danuta , Kaźmierski Radosław 
Published: January 2022

AbstractThis study aims to investigate whether wearing a filtering facepiece class 3 respirators with personal protective equipment (FPP3/PPE) during work in the intensive care unit (ICU) affects the blood saturation (SpO2), the heart rate (HR), and the well-being of health care workers (HCWs). This preliminary study included a group of 21 volunteers (including 16 females (76%), with a median age of 23 years). Each worker served as his own control and performed the test two times: they wore the FFP3/PPE and did not wear it for a three-hour shift in the ICU. The working with an FFP3/PPE compared to not working with an FFP3/PPE caused a significant, but within normal ranges, influence on the level of SpO2 with a mean decrease of − 1.43%. The highest reduction in the SpO2 was − 2.29% and occurred after 150 min of work. All of the score scales of the well-being markers increased consecutively but moderately during the shift while wearing the FFP3/PPE. We assume that a 3-h shift rhythm is a safe and reliable solution, i.e., three hours of working in the FFP3/PPE in the ICU, followed by rest or working without an FFP3/PPE.
Study on the effect of size on InGaN red micro-LEDs
Authors: Horng Ray-Hua , Ye Chun-Xin , Chen Po-Wei , Iida Daisuke , Ohkawa Kazuhiro , Wu Yuh-Renn , Wuu Dong-Sing 
Published: January 2022

AbstractIn this research, five sizes (100 × 100, 75 × 75, 50 × 50, 25 × 25, 10 × 10 µm2) of InGaN red micro-light emitting diode (LED) dies are produced using laser-based direct writing and maskless technology. It is observed that with increasing injection current, the smaller the size of the micro-LED, the more obvious the blue shift of the emission wavelength. When the injection current is increased from 0.1 to 1 mA, the emission wavelength of the 10 × 10 μm2 micro-LED is shifted from 617.15 to 576.87 nm. The obvious blue shift is attributed to the stress release and high current density injection. Moreover, the output power density is very similar for smaller chip micro-LEDs at the same injection current density. This behavior is different from AlGaInP micro-LEDs. The sidewall defect is more easily repaired by passivation, which is similar to the behavior of blue micro-LEDs. The results indicate that the red InGaN epilayer structure provides an opportunity to realize the full color LEDs fabricated by GaN-based LEDs.
Path planning of scenic spots based on improved A* algorithm
Authors: Wang Xingdong , Zhang Haowei , Liu Shuo , Wang Jialu , Wang Yuhua , Shangguan Donghui 
Published: January 2022

AbstractTraditional scenic route planning only considers the shortest path, which ignores the information of scenic road conditions. As the most effective direct search method to solve the shortest path in static road network, A* algorithm can plan the optimal scenic route by comprehensively evaluating the weights of each expanded node in the gridded scenic area. However, A* algorithm has the problem of traversing more nodes and ignoring the cost of road in the route planning. In order to bring better travel experience to the travelers, the above factors are taken into account. This paper presents a path planning method based on the improved A* algorithm. Firstly, the heuristic function of the A* algorithm is weighted by exponential decay to improve the calculation efficiency of the algorithm. Secondly, in order to increase the practicality of the A* algorithm, the impact factors that road conditions is introduced to the evaluation function. Finally, the feasibility of the improved A* algorithm is verified through simulation experiments. Experimental results show that the improved A* algorithm can effectively reduce the calculation time and road cost.
Diagnostic and therapeutic characteristics of diabetes mellitus and risk of out-of-hospital cardiac arrest
Authors: Park Jeong Ho , Ro Young Sun , Shin Sang Do , Cha Kyoung-Chul , Song Kyoung Jun , Hwang Sung Oh ,   For the phase II Cardiac Arrest Pursuit Trial with Unique Registry and Epidemiologic Surveillance (CAPTURES-II) investigators, Hwang Sung Oh , Shin Sang Do , Lee Mi Jin , Park Jong-Hak , Kim Su Jin , Oh Sung Bum , Shin Jonghwan , Park Seung Min , Sim Min Seob , Kim Won Young , Park In-Cheol , Ryu Hyun Ho , You Yeonho , Kim Sang-Chul , Park Ju Ok 
Published: January 2022

AbstractThis study aimed to evaluate the risks of diabetes mellitus (DM) on out-of-hospital cardiac arrest (OHCA) and to investigate whether the risks of DM on OHCA varied according to the diagnostic and therapeutic characteristics of diabetes. We conducted a multicenter prospective case–control study in 17 University hospitals in Korea from September 2017 to December 2020. Cases were EMS-treated OHCA patients aged 20 to 79 with a presumed cardiac etiology. Community-based controls were recruited at a 1:2 ratio after matching for age, sex, and urbanization level of residence. A structured questionnaire and laboratory findings were collected from cases and controls. Multivariable conditional logistic regression analyses were conducted to estimate the risk of DM on OHCA by characteristics. A total of 772 OHCA cases and 1544 community-based controls were analyzed. A total of 242 (31.3%) OHCAs and 292 (18.9%) controls were previously diagnosed with DM. The proportions of type I DM (10.7% vs. 2.1%) and insulin therapy (15.3% vs. 6.5%) were higher in OHCAs with DM than in controls with DM. The duration of DM was longer in OHCAs than in controls (median 12 vs. 7 years). DM was associated with an increased risk of OHCA (aOR (95% CI), 2.13 (1.64–2.75)). Compared to the no diabetes group, the risks of OHCA increased in the diabetes patients with type I DM (5.26 (1.72–16.08)) and type II DM group (1.63 (1.18–2.27)), a long duration of DM prevalence (1.04 (1.02–1.06) per 1-year prevalence duration), and a high HbA1c level (1.38 (1.19–1.60) per 1% increase). By treatment modality, the aOR (95% CI) was lowest in the oral hypoglycemic agent (1.47 (1.08–2.01)) and highest in the insulin (6.63 (3.04–14.44)) groups. DM was associated with an increased risk of OHCA, and the risk magnitudes varied according to the diagnostic and therapeutic characteristics.
Effect of vibration on orthodontic tooth movement in a double blind prospective randomized controlled trial
Authors: Mayama Atsushi , Seiryu Masahiro , Takano-Yamamoto Teruko 
Published: January 2022

AbstractThe purpose of the present study was to investigate the effect of vibration on orthodontic tooth movement and safety assessment based on our previous basic research in animal experiments. A double-blind prospective randomized controlled trial using split-mouth design was conducted in patients with malocclusion. The left and right sides of maxillary arch were randomly assigned to vibration (TM + V) and non-vibration (TM) groups. After leveling, vibrations (5.2 ± 0.5 g-forces (gf), 102.2 ± 2.6 Hertz (Hz)) were supplementary applied to the canine retracted with 100 gf in TM + V group for 3 min at the monthly visit under double-blind fashion, and the canine on the other side without vibration was used as TM group. The amount of tooth movement was measured blindly using a constructed three-dimensional dentition model. The amount of canine movement per visit was 0.89 ± 0.55 mm in TM group (n = 23) and 1.21 ± 0.60 mm in TM + V group (n = 23), respectively. There was no significant difference of pain and discomfort, and root resorption between the two groups. This study indicates that static orthodontic force with supplementary vibration significantly accelerated tooth movement in canine retraction and reduced the number of visits without causing side effects.
Stepwise slime mould growth as a template for urban design
Authors: Kay Raphael , Mattacchione Anthony , Katrycz Charlie , Hatton Benjamin D. 
Published: January 2022

AbstractThe true slime mould, Physarum polycephalum, develops as a vascular network of protoplasm, connecting node-like sources of food in an effort to solve multi-objective transport problems. The organism first establishes a dense and continuous mesh, reinforcing optimal pathways over time through constructive feedbacks of protoplasmic streaming. Resolved vascular morphologies are the result of an evolutionarily-refined mechanism of computation, which can serve as a versatile biological model for network design at the urban scale. Existing digital Physarum models typically use positive reinforcement mechanisms to capture meshing and refinement behaviours simultaneously. While these automations generate accurate descriptions of sensory and constructive feedback, they limit stepwise design control, reducing flexibility and applicability. A model that decouples the two “phases” of Physarum behaviour would enable multistage control over network growth. Here we introduce such a system, first by producing a site-responsive mesh from a population of nutrient-attracted agents, and then by independently calculating from it a flexible, proximity-defined shortest-walk to produce a final network. We develop and map networks within existing urban environments that perform similarly to those biologically grown, establishing a versatile tool for bio-inspired urban network design.
Swallowing kinematic analysis might be helpful in predicting aspiration and pyriform sinus stasis
Authors: Wei Kuo-Chang , Cheng Sheng-Hao , Hsiao Ming-Yen , Wang Yu-Chen , Weng Chi-Hung , Chen Jo-Yu , Wang Tyng-Guey 
Published: January 2022

AbstractAspiration due to dysphagia can lead to aspiration, which negatively impacts a patient’s overall prognosis. Clinically, videofluoroscopic swallow study (VFSS) is considered the gold-standard instrument to determine physiological impairments of swallowing. According to previously published literature, kinematic analyses of VFSS might provide further information regarding aspiration detection. In this study, 449 files of VFSS studies from 232 patients were divided into three groups: normal, aspiration, and pyriform sinus stasis. Kinematic analyses and between-group comparison were conducted. Significant between-group differences were noted among parameters of anterior hyoid displacement, maximal hyoid displacement, and average velocity of hyoid movement. No significant difference was detected in superior hyoid displacement. Furthermore, receiver-operating characteristic (ROC) analyses of anterior hyoid displacement, velocity of anterior hyoid displacement, and average velocity of maximal hyoid displacement showed acceptable predictability for detecting aspiration. Using 33.0 mm/s as a cutoff value of average velocity of maximal hyoid displacement, the sensitivity of detecting the presence of aspiration was near 90%. The investigators therefore propose that the average velocity of maximal hyoid displacement may serve as a potential screening tool to detect aspiration.
Dual isoform sequencing reveals complex transcriptomic and epitranscriptomic landscapes of a prototype baculovirus
Authors: Torma Gábor , Tombácz Dóra , Moldován Norbert , Fülöp Ádám , Prazsák István , Csabai Zsolt , Snyder Michael , Boldogkői Zsolt 
Published: January 2022

AbstractIn this study, two long-read sequencing (LRS) techniques, MinION from Oxford Nanopore Technologies and Sequel from the Pacific Biosciences, were used for the transcriptional characterization of a prototype baculovirus, Autographa californica multiple nucleopolyhedrovirus. LRS is able to read full-length RNA molecules, and thereby distinguish between transcript isoforms, mono- and polycistronic RNAs, and overlapping transcripts. Altogether, we detected 875 transcript species, of which 759 were novel and 116 were annotated previously. These RNA molecules include 41 novel putative protein coding transcripts [each containing 5′-truncated in-frame open reading frames (ORFs), 14 monocistronic transcripts, 99 polygenic RNAs, 101 non-coding RNAs, and 504 untranslated region isoforms. This work also identified novel replication origin-associated transcripts, upstream ORFs, cis-regulatory sequences and poly(A) sites. We also detected RNA methylation in 99 viral genes and RNA hyper-editing in the longer 5′-UTR transcript isoform of the canonical ORF 19 transcript.
Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction
Authors: Yang Duomeng , Dai Xiaomeng , Xing Yun , Tang Xiangxu , Yang Guang , Harrison Andrew G. , Cahoon Jason , Li Hongmei , Lv Xiuxiu , Yu Xiaohui , Wang Penghua , Wang Huadong 
Published: January 2022

Abstract
Intrinsic cardiac adrenergic (ICA) cells regulate both developing and adult cardiac physiological and pathological processes. However, the role of ICA cells in septic cardiomyopathy is unknown. Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-α production and dysfunction by lipopolysaccharide (LPS). In ICA cells, LPS activated TLR4-MyD88/TRIF-AP-1 signaling that promoted NE biosynthesis through expression of tyrosine hydroxylase, but did not trigger TNF-α production due to impairment of p65 translocation. In a co-culture consisting of LPS-treated ICA cells and cardiomyocytes, the upregulation and secretion of NE from ICA cells activated cardiomyocyte β1-adrenergic receptor driving Ca2+/calmodulin-dependent protein kinase II (CaMKII) to crosstalk with NF-κB and mitogen-activated protein kinase pathways. Importantly, blockade of ICA cell-derived NE prevented LPS-induced myocardial dysfunction. Our findings suggest that ICA cells may be a potential therapeutic target for septic cardiomyopathy.
Neurons learn by predicting future activity
Authors: Luczak Artur , McNaughton Bruce L. , Kubo Yoshimasa 
Published: January 2022

AbstractUnderstanding how the brain learns may lead to machines with human-like intellectual capacities. It was previously proposed that the brain may operate on the principle of predictive coding. However, it is still not well understood how a predictive system could be implemented in the brain. Here we demonstrate that the ability of a single neuron to predict its future activity may provide an effective learning mechanism. Interestingly, this predictive learning rule can be derived from a metabolic principle, whereby neurons need to minimize their own synaptic activity (cost) while maximizing their impact on local blood supply by recruiting other neurons. We show how this mathematically derived learning rule can provide a theoretical connection between diverse types of brain-inspired algorithm, thus offering a step towards the development of a general theory of neuronal learning. We tested this predictive learning rule in neural network simulations and in data recorded from awake animals. Our results also suggest that spontaneous brain activity provides ‘training data’ for neurons to learn to predict cortical dynamics. Thus, the ability of a single neuron to minimize surprise—that is, the difference between actual and expected activity—could be an important missing element to understand computation in the brain.
Wildland fire smoke alters the composition, diversity, and potential atmospheric function of microbial life in the aerobiome
Authors: Kobziar Leda N , Vuono David , Moore Rachel , Christner Brent C , Dean Timothy , Betancourt Doris , Watts Adam C , Aurell Johanna , Gullett Brian 
Published: January 2022

Abstract
The atmosphere contains a diverse reservoir of microbes but the sources and factors contributing to microbial aerosol variability are not well constrained. To advance understanding of microbial emissions in wildfire smoke, we used unmanned aircraft systems to analyze the aerosols above high-intensity forest fires in the western United States. Our results show that samples of the smoke contained ~four-fold higher concentrations of cells (1.02 ± 0.26 × 105 m−3) compared to background air, with 78% of microbes in smoke inferred to be viable. Fivefold higher taxon richness and ~threefold enrichment of ice nucleating particle concentrations in smoke implies that wildfires are an important source of diverse bacteria and fungi as well as meteorologically relevant aerosols. We estimate that such fires emit 3.71 × 1014 microbial cells ha−1 under typical wildfire conditions in western US forests and demonstrate that wildland biomass combustion has a large-scale influence on the local atmospheric microbial assemblages. Given the long-range transport of wildfire smoke emissions, these results expand the concept of a wildfire’s perimeter of biological impact and have implications to biogeography, gene flow, the dispersal of plant, animal, and human pathogens, and meteorology.
The earliest O-type eclipsing binary in the Small Magellanic Cloud, AzV 476: A comprehensive analysis reveals surprisingly low stellar masses
Authors: Pauli D. , Oskinova L. M. , Hamann W.-R. , Ramachandran V. , Todt H. , Sander A. A. C. , Shenar T. , Rickard M. , Maíz Apellániz J. , Prinja R. 
Published: January 2022

Context. Massive stars at low metallicity are among the main feedback agents in the early Universe and in present-day star forming galaxies. When in binaries, these stars are potential progenitors of gravitational-wave events. Knowledge of stellar masses is a prerequisite to understanding evolution and feedback of low-metallicity massive stars.
Aims. Using abundant spectroscopic and photometric measurements of an outstandingly bright eclipsing binary, we compare its dynamic, spectroscopic, and evolutionary mass estimates and develop a binary evolution scenario.
Methods. We comprehensively studied the eclipsing binary system, AzV 476, in the Small Magellanic Cloud (SMC). The light curve and radial velocities were analyzed to obtain the orbital parameters. The photometric and spectroscopic data in the UV and optical were analyzed using the Potsdam Wolf–Rayet (PoWR) model atmospheres. The obtained results are interpreted using detailed binary-evolution tracks including mass transfer.
Results. AzV 476 consists of an O4 IV-III((f))p primary and an O9.5: Vn secondary. Both components have similar current masses (20 M⊙ and 18 M⊙) obtained consistently from both the orbital and spectroscopic analysis. The effective temperatures are 42 kK and 32 kK, respectively. The wind mass-loss rate of log(Ṁ∕(M⊙ yr−1)) = −6.2 of the primary is a factor of ten higher than a recent empirical prescription for single O stars in the SMC. Only close-binary evolution with mass transfer can reproduce the current stellar and orbital parameters, including orbital separation, eccentricity, and the rapid rotation of the secondary. The binary evolutionary model reveals that the primary has lost about half of its initial mass and is already core helium burning.
Conclusions. Our comprehensive analysis of AzV 476 yields a consistent set of parameters and suggests previous case B mass transfer. The derived stellar masses agree within their uncertainties. The moderate masses of AzV 476 underline the scarcity of bright massive stars in the SMC. The core helium burning nature of the primary indicates that stripped stars might be hidden among OB-type populations.