bluuebunny/crossref_metadata_2025_split huggingface dataset:
The higher-dimensional origin of five-dimensional $$ \mathcal{N} $$ = 2 gauged supergravities
Authors: Josse Grégoire , Malek Emanuel , Petrini Michela , Waldram Daniel 
Published: June 2022

Abstract
Using exceptional generalised geometry, we classify which five-dimensional $$ \mathcal{N} $$
N
= 2 gauged supergravities can arise as a consistent truncation of 10-/11-dimensional supergravity. Exceptional generalised geometry turns the classification into an algebraic problem of finding subgroups GS ⊂ USp(8) ⊂ E6(6) that preserve exactly two spinors. Moreover, the intrinsic torsion of the GS structure must contain only constant singlets under GS, and these, in turn, determine the gauging of the five-dimensional theory. The resulting five-dimensional theories are strongly constrained: their scalar manifolds are necessarily symmetric spaces and only a small number of matter multiplets can be kept, which we completely enumerate. We also determine the largest reductive and compact gaugings that can arise from consistent truncations.
Asymptotic critical behavior of holographic superconductor phase transition — the spectrum of excited states becomes continuous at T = 0
Authors: Nguyen Toan T. , Phat Tran Huu 
Published: June 2022

Abstract
Within the framework of AdS/CFT duality, excited states of the conformal field living at the global AdS boundary of a four-dimensional spacetime Einstein gravity are investigated analytically in the probe limit where the field equations are linearized. At asymptotically large values, the threshold chemical potential for the appearance of excited condensate states are discrete, equal spacing, with the gap approaches zero logarithmically in the limit T → 0. Remarkably, numerical results show that, this behavior applies even for states as low as for the first or the second excited state of the condensate. This is especially significant on the liquid side of the black hole van der Waals-like phase transition (small or zero topological charge) where there seems to be no gap between the ground state and the first excited state at zero temperature. We postulate that, at the exact limit T = 0 where the gap is zero, the spectrum of threshold chemical potentials becomes continuous, all excited states of the condensate are activated above a finite chemical potential, suggesting a new quantum phase transition as a function of the chemical potential. Previous studies have largely missed this continuous spectrum of excited states in the T → 0 limit. This fact should be taken into account carefully in AdS/CFT duality studies.
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Authors: Merino Beatriz , Casanueva-Álvarez Elena , Quesada Iván , González-Casimiro Carlos M. , Fernández-Díaz Cristina M. , Postigo-Casado Tamara , Leissring Malcolm A. , Kaestner Klaus H. , Perdomo Germán , Cózar-Castellano Irene 
Published: June 2022

Abstract
Aims/hypothesis
Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet cells, mostly in alpha cells, in both mice and humans. Furthermore, IDE can degrade glucagon as well as insulin, suggesting that IDE may play an important role in alpha cell function in vivo.

Methods
We have generated and characterised a novel mouse model with alpha cell-specific deletion of Ide, the A-IDE-KO mouse line. Glucose metabolism and glucagon secretion in vivo was characterised; isolated islets were tested for glucagon and insulin secretion; alpha cell mass, alpha cell proliferation and α-synuclein levels were determined in pancreas sections by immunostaining.

Results
Targeted deletion of Ide exclusively in alpha cells triggers hyperglucagonaemia and alpha cell hyperplasia, resulting in elevated constitutive glucagon secretion. The hyperglucagonaemia is attributable in part to dysregulation of glucagon secretion, specifically an impaired ability of IDE-deficient alpha cells to suppress glucagon release in the presence of high glucose or insulin. IDE deficiency also leads to α-synuclein aggregation in alpha cells, which may contribute to impaired glucagon secretion via cytoskeletal dysfunction. We showed further that IDE deficiency triggers impairments in cilia formation, inducing alpha cell hyperplasia and possibly also contributing to dysregulated glucagon secretion and hyperglucagonaemia.

Conclusions/interpretation
We propose that loss of IDE function in alpha cells contributes to hyperglucagonaemia in type 2 diabetes.

Graphical abstract
Simultaneous quantification of eight hemoglobin adducts of genotoxic substances by isotope-dilution UHPLC-MS/MS
Authors: Gauch Fabian , Abraham Klaus , Monien Bernhard H. 
Published: June 2022

AbstractVarious genotoxic carcinogens ubiquitously present in the human environment or respective reactive metabolites form adducts in DNA and proteins, which can be used as biomarkers of internal exposure. For example, the mass spectrometric determination of Val adducts at the N-termini of hemoglobin (Hb) peptide chains after cleavage by an Edman degradation has a long tradition in occupational medicine. We developed a novel isotope-dilution UHPLC-MS/MS method for the simultaneous quantification of Val adducts of eight genotoxic substances in Hb after cleavage with fluorescein-5-isothiocyanate (FIRE procedure™). The following adducts were included [sources in square brackets]: N-(2,3-dihydroxypropyl)-Val [glycidol], N-(2-carbamoylethyl)-Val [acrylamide], N-(2-carbamoyl-2-hydroxyethyl)-Val [glycidamide], N-((furan-2-yl)methyl)-Val [furfuryl alcohol], N-(trans-isoestragole-3′-yl)-Val [estragole/anethole], N-(3-ketopentyl)-Val [1-penten-3-one], N-(3-ketooctanyl)-Val [1-octene-3-one], and N-benzyl-Val [benzyl chloride], each of which was quantified with a specific isotope-labeled standard. The limits of quantification were between 0.014 and 3.6 pmol/g Hb (using 35 mg Hb per analysis); other validation parameters were satisfactory according to guidelines of the U.S. Food and Drug Administration. The quantification in erythrocyte samples of human adults (proof of principle) showed that the median levels of Hb adducts of acrylamide, glycidamide, and glycidol were found to be significantly lower in six non-smokers (25.9, 12.2, and 4.7 pmol/g Hb, respectively) compared to those of six smokers (69.0, 44.2, and 8.6 pmol/g Hb, respectively). In summary, the method surpasses former techniques of Hb adduct quantification due to its simplicity, sensitivity, and accuracy. It can be extended continuously with other Hb adducts and will be used in epidemiological studies on internal exposure to carcinogens.
Graphical abstract
Visual perception and macular integrity in non-classical CLN2 disease
Authors: Atiskova Yevgeniya , Wildner Jan , Wibbeler Eva , Nickel Miriam , Spitzer Martin Stephan , Schwering Christoph , Schulz Angela , Dulz Simon 
Published: June 2022

Abstract
Purpose
Patients with CLN2 suffer from epileptic seizures, rapid psychomotor decline and vision loss in early childhood. The aim of the study was to provide longitudinal ophthalmic data of patients with confirmed genetic mutation and non-classical disease course, marked by later onset, protracted progression and prolonged life span.

Methods
Prospective, observational study to assess visual acuity, retinal features (Weil Cornell Ophthalmic Score), central retinal thickness (CRT) measured by optical coherence tomography and general disease progression (Hamburg CLN2 motor language score) in non-classical CLN2 patients.

Results
All patients received intracerebroventricular enzyme replacement therapy with cerliponase alfa. Mean age at last follow-up was 12.4 years; mean follow-up time 2.6 years. All cases demonstrated a stable Hamburg motor language CLN2 Score and Weill Cornell LINCL Ophthalmic Severity Score. Visual function remained stable in 4/6 patients, 2/6 patients showed a decrease, 4/6 cases had a stable CRT and 2/6 showed a reduction of CRT. One patient showed a massive macular thinning and low vision. A correlation with a specific mutation or age could not be verified.

Discussion
The presented longitudinal study characterizes the variable ocular involvement in non-classical CLN2 disease and contributes to the natural history description. The functional and morphologic data outline the necessity of regular ophthalmic examination.

Summary statement

Ocular phenotyping and description of retinal degeneration in non-classical CLN2 disease.
Intravitreal aflibercept for diabetic macular edema in real-world clinical practice in Japan: 24-month outcomes
Authors: Sugimoto Masahiko , Handa Chiharu , Hirano Kazufumi , Sunaya Toshiyuki , Kondo Mineo 
Published: June 2022

Abstract
Purpose
To report the safety and effectiveness of intravitreal aflibercept (IVT-AFL) for diabetic macular edema (DME) in the real-world clinical practice setting in Japan.

Methods
In this prospective, multicenter, observational, post-marketing surveillance, patients with DME newly receiving IVT-AFL were enrolled. During a 24-month follow-up, the primary outcome was the occurrence of safety events. Other pre-specified endpoints were effectiveness indicators, such as best-corrected visual acuity (BCVA), central retinal thickness, and injection frequency.

Results
In total, 646 patients administered at least one IVT-AFL injection were included in the safety analysis. During the follow-up period, adverse events occurred in 42 patients (6.50%), whereas adverse drug reactions occurred in 12 (1.86%). In the 12 patients who had adverse drug reactions, seven events occurred in seven patients within the first month of the most recent injection. In addition, 622 patients were included in the effectiveness analysis set. The number of injections over 24 months was 3.6 ± 3.0 (mean ± standard deviation [SD]). BCVA (logarithm of the minimum angle of resolution) was 0.437 ± 0.362 (mean ± SD) (n = 622) at baseline and 0.321 ± 0.348 (n = 177) after 24 months of treatment with IVT-AFL. Central retinal thickness was 440.8 ± 134.2 μm (mean ± SD) (n = 444) at baseline and 355.5 ± 126.4 μm (n = 140) at 24 months.

Conclusion
Routine administration of IVT-AFL for DME was not associated with new safety concerns, and BCVA outcomes were maintained over 24 months in the real-world setting. Nonetheless, patients in this real-world setting received fewer injections than those in clinical trials, suggesting that a margin for improvement exists in clinical practice.

Trial registration
ClinicalTrials.gov: NCT02425501.
The influence of summer closure on serious postoperative complications in bariatric surgery
Authors: Fall Johanna , Sundbom Magnus , Stenberg Erik 
Published: June 2022

Abstract

Introduction
Bariatric surgery is an effective method of treating obesity, with gastric bypass and sleeve gastrectomy being the most common techniques used worldwide. Despite the technical challenges in these methods, little is known about the effects of summer closure on the incidence of serious postoperative complications in surgeries performed shortly after summer vacation. This has therefore been studied in our large cohort.

Materials and methods
A retrospective cohort study based on data from the Scandinavian Obesity Surgery Registry was conducted. Patients who underwent a primary gastric bypass or sleeve gastrectomy operation between 2010 and 2019 were included. The rate of serious complications within 30 days after surgery for patients who underwent surgery the first month after summer closure was compared to those who underwent surgery during the rest of the year using the χ2 test and adjusted logistic regression.

Results
The study included 42,404 patients, 36,094 of whom underwent gastric bypass and 6310 of whom received sleeve gastrectomy. Summer closure was associated with an increased risk for serious postoperative complications in gastric bypass surgery (adjusted odds ratio (adj-OR) = 1.17; 95% confidence interval (CI): 1.01–1.36). No statistically significant association was seen for sleeve gastrectomy (adj-OR = 1.17; 95% CI: 0.72–1.91), nor in overall complication rate.

Conclusions
Summer closure increases the risk of serious postoperative complications in gastric bypass surgery. No statistically significant association was found for sleeve gastrectomy surgery.
Mixed lymphocytic and collagenous inflammation of the entire gastrointestinal tract under therapy with serotonin and norepinephrine reuptake inhibitors
Authors: Varelas Ana I. , Fürst Stefan , Langner Cord 
Published: June 2022

Abstract
Drug-induced injury to the gastrointestinal tract has gained growing significance in recent years, and the list of causative medications keeps expanding. Herein, we present the case of a 45-year-old female with major depressive disorder treated with two serotonin and norepinephrine reuptake inhibitors (venlafaxine and duloxetine). She developed nausea and weight loss. Endoscopic evaluation of the upper and lower gastrointestinal tract rendered grossly normal mucosa in all segments. Histological examination, however, revealed lymphocytic esophagitis, collagenous gastritis, celiac disease-like intraepithelial lymphocytosis of the duodenum, and incomplete collagenous colitis. Gastrointestinal side effects of psychoactive drugs are largely underrecognized. This is the first report of a mixed lymphocytic and collagenous pattern of injury affecting esophagus, stomach, duodenum, and colon triggered by combined treatment with venlafaxine and duloxetine. In patients with unclear symptoms, obtaining biopsies from mucosa that is normal upon endoscopic inspection may render decisive clues for clinical management.
Multi-physical modeling and numerical simulation of the thermo-hygro-mechanical treatment of wood
Authors: Fleischhauer Robert , Kaliske Michael 
Published: June 2022

AbstractThe contribution at hand introduces computational modeling and realistic simulation concepts for a comprehensive description of the manufacturing and application of densified wood and wooden structures made from molded densified wood. Wood, as a natural material, is characterized by e.g. a very good mechanical load-bearing capacity related to its density. Nevertheless, the ratio between its mechanical properties and its density can be optimized by densification technology for an expanded use of wood in structural engineering. The wood densification process is not only a mechanical process with large and irreversible deformations, it is also denoted by temperature- and moisture-dependent treatments of the wooden specimens. Thus, the introduced approaches to predict the material and structural characteristics of compressed and molded wood consist of an inelastic and multi-physical constitutive modeling of wood at finite deformations as well as the computation of effective structural properties of wood after the thermo-hygro-mechanical densification process. A successful implementation of the modeling concepts into the finite element method (FEM) is presented, which is verified by numerical investigations. A validation of the numerical results is carried out by use of experimental data at beech wood (Fagus Sylvatica, L.), taken from literature.
Unified landslide hazard assessment using hurdle models: a case study in the Island of Dominica
Authors: Bryce Erin , Lombardo Luigi , van Westen Cees , Tanyas Hakan , Castro-Camilo Daniela 
Published: June 2022

AbstractClimatically-induced natural hazards are a threat to communities. They can cause life losses and heavy damage to infrastructure, and due to climate change, they have become increasingly frequent. This is especially the case in tropical regions, where major hurricanes have consistently appeared in recent history. Such events induce damage due to the high wind speed they carry, and the high intensity/duration of rainfall they discharge can further induce a chain of hydro-morphological hazards in the form of widespread debris slides/flows. The way the scientific community has developed preparatory steps to mitigate the potential damage of these hydro-morphological threats includes assessing where they are likely to manifest across a given landscape. This concept is referred to as susceptibility, and it is commonly achieved by implementing binary classifiers to estimate probabilities of landslide occurrences. However, predicting where landslides can occur may not be sufficient information, for it fails to convey how large landslides may be. This work proposes using a flexible Bernoulli-log-Gaussian hurdle model to simultaneously model landslide occurrence and size per areal unit. Covariate and spatial information are introduced using a generalised additive modelling framework. To cope with the high spatial resolution of the data, our model uses a Markovian representation of the Matérn covariance function based on the stochastic partial differential equation approach. Assuming Gaussian priors, our model can be integrated into the class of latent Gaussian models, for which inference is conveniently performed based on the integrated nested Laplace approximation method. We use our modelling approach in Dominica, where hurricane Maria (September 2017) induced thousands of shallow flow-like landslides passing over the island. Our results show that we can not only estimate where landslides may occur and how large they may be, but we can also combine this information in a unified landslide hazard model, which is the first of its kind.
The effect of aerobic exercise on tumour blood delivery: a systematic review and meta-analysis
Authors: Seet-Lee Catherine , Yee Jasmine , Morahan Heidi , Ross Lois S. , Edwards Kate M. 
Published: June 2022

Abstract
Purpose
Tumour blood vessels are structurally and functionally abnormal, resulting in areas of hypoxia and heterogeneous blood supply. Aerobic exercise may modulate tumour blood flow and normalise the tumour microenvironment to improve chemotherapy delivery. This systematic review and meta-analysis aimed to evaluate the effect of the aerobic exercise mode on tumour hypoxia, vascularisation and blood flow.

Methods
Four online databases were searched. Preclinical and clinical randomised controlled trials examining the effects of aerobic exercise training on hypoxia, vascularisation or blood flow in solid tumours were included. The risk of bias was assessed and a meta-analysis performed.

Results
Seventeen preclinical studies and one clinical study met criteria. Eleven studies assessed hypoxia, 15 studies assessed vascularisation and seven evaluated blood flow. There was large variability in measurement methods, tumour types and exercise program designs. The overall risk of bias was unclear in clinical and preclinical studies, owing to poor reporting. There was no significant effect of aerobic exercise on hypoxia (SMD = −0.17; 95% CI = −0.62, 0.28; I2 = 60%), vascularisation (SMD = 0.07; 95% CI = −0.40, 0.55; I2 = 71%) or blood flow (SMD = 0.01; 95% CI = −0.59, 0.61; I2 = 63%).

Conclusion
There is heterogeneity in methodology, resulting in evidence that is inconsistent and inconclusive for the effects of aerobic exercise on hypoxia, vascularisation and blood flow. Most evidence of aerobic exercise effects on tumour blood flow is in animal models, with very limited evidence in humans.
Mobilität auf dem Klimaprüfstand: Bahnverkehr
Authors: Eisenkopf Alexander 
Published: June 2022

ZusammenfassungIm Zuge der politisch und gesellschaftlich propagierten „Verkehrs- und Klimawende“ wird der Stärkung des Schienenverkehrs in Deutschland eine zunehmend wichtigere Rolle beigemessen. Mit der Coronakrise ist die Klimadebatte zwar zwischenzeitlich etwas aus den Schlagzeilen verschwunden; es ist jedoch davon auszugehen, dass sie spätestens nach dem Ende der Pandemie mit zunehmender Intensität fortgeführt werden und auch in der Verkehrspolitik zu entsprechenden Weichenstellungen führen wird.
Die große Zeit des Autos kommt erst
Authors: Dudenhöffer Ferdinand 
Published: June 2022

ZusammenfassungDer Bestand an Pkw steigt stetig an. Die Nachfrage nach individueller Mobilität ist somit hoch und nimmt weiter zu. Die Herausforderung ist, das Auto klimaneutral zu gestalten. Vollelektrische Autos spielen hier eine zentrale Rolle. Dabei darf der Strombedarf nicht unterschätzt und muss für die Zukunft sichergestellt werden. Daneben wird das autonom fahrende Fahrzeug an Bedeutung gewinnen. China ist hier bereits Vorreiter. Deutschland kann von China lernen, sodass auch künftig das Auto das wichtigste Verkehrsmittel sein wird.
Cooperative Carbon Alliances: Defining an Agenda for Global Industrial Decarbonisation
Authors: Shawkat Aylin , Sartor Oliver 
Published: June 2022

AbstractThere have been several recent proposals for cooperative climate alliances, from the OECD, the IMF, the World Trade Organization (WTO), the German Government, and others. The “Climate Club” concept comprises many different possible regimes and intents. They range from so-called transformational clubs (which incentivise membership and penalise non-members), to looser joint agreements on ambition level for climate action, such as the UN’s Net-Zero Coalition. Given this option, there is not yet any agreement on how to design such a “club”, or its aims, rules, or scope of membership.
Impact of extreme rainfall events on landslide activity in Portugal under climate change scenarios
Authors: Araújo Joana R. , Ramos Alexandre M. , Soares Pedro M. M. , Melo Raquel , Oliveira Sérgio C. , Trigo Ricardo M. 
Published: June 2022

AbstractRainfall is considered the most important physical process for landslide triggering in Portugal. It is expected that changes in the precipitation regimes in the region, as a direct consequence of climate change, will have influence in the occurrence of extreme rainfall events that will be more frequently, throughout the century. The aim of this study relied on the assessment of the projected future changes in the extreme precipitation over Portugal mainland and quantifying the correlation between extreme rainfall events and landslide events through Rainfall Triggering Thresholds (RTTs). This methodology was applied for two specific locations within two Portuguese areas of great geomorphological interest. To analyze the past frequency of landslide events, we resorted to the DISASTER database. To evaluate the possible projected changes in the extreme precipitation, we used the Iberia02 dataset and the EURO-CORDEX models’ runs at a 0.11° spatial resolution. It was analyzed the models’ performance to simulate extreme values in the precipitation series. The simulated precipitation relied on RCM-GCM models’ runs, from EURO-CORDEX, and a multimodel ensemble mean. The extreme precipitation assessment relied on the values associated to the highest percentiles, and to the values associated to the RTTs’ percentiles. To evaluate the possible future changes of the precipitation series, both at the most representative percentiles and RTTs’ percentiles, a comparison was made between the simulated values from EURO-CORDEX historical runs (1971–2000) and the simulated values from EURO-CORDEX future runs (2071–2100), considering two concentration scenarios: RCP 4.5 and RCP 8.5. In the models’ performance, the multimodel ensemble mean appeared to be within the best representing models. As for the projected changes in the extreme precipitation for the end of the century, when following the RCP 4.5 scenario, most models projected an increase in the extreme values, whereas, when following the RCP 8.5 scenario, most models projected a decrease in the extreme values.