bluuebunny/crossref_metadata_2025_split huggingface dataset:
High serum levels of N-epsilon-carboxymethyllysine are associated with poor coronary collateralization in type 2 diabetic patients with chronic total occlusion of coronary artery
Authors: Li Le-Ying , Chen Shuai , Li Fei-Fei , Wu Zhi-Ming , Shen Ying , Ding Feng-Hua , Wang Xiao-Qun , Shen Wei-Feng , Chen Qiu-Jing , Dai Yang , Lu Lin 
Published: February 2022

Abstract
Background: The formation of advanced glycation end-products (AGEs) is a crucial risk factor for the pathogenesis of cardiovascular diseases. We investigated whether N-epsilon-carboxymethyllysine (CML), a major form of AGEs in vivo, was associated with poor coronary collateral vessel (CCV) formation in patients with type 2 diabetes mellitus (T2DM) and chronic total occlusion (CTO) of coronary artery.Methods: This study consisted of 242 T2DM patients with angiographically documented CTO. Blood samples were obtained and demographic/clinical characteristics were documented. The collateralization of these patients was defined according to Rentrop score. Receiver operating characteristic curve and multivariable regression analysis were performed.Results: 242 patients were categorized into poor CCV group (Rentrop score 0 and 1)(n=107) and good CCV group (Rentrop score 2 and 3)(n=135). Serum CML levels were significantly higher in poor CCV group (110.0 ± 83.35 ng/ml) than in good CCV group (62.95 ± 58.83 ng/ml, P<0.001). Moreover, these CML levels were also significantly different across the Rentrop score 0, 1, 2 and 3 groups (P<0.001). In multivariable logistic regression, CML levels (P<0.001) remained independent determinants of poor CCV after adjustment of traditional risk factors. Conclusions: This study suggests that higher CML is associated with poor collateralization in T2DM patients with CTO.
Theoretical study of the reactivity between HCO and CH2 in interstellar medium
Authors: abbas Haider , Bardhan Ananna , Gupta Riya , Shallu Shallu 
Published: February 2022

Abstract
Barrierless radical-radical reactions may be considered as a favorable process for the formation of interstellar organic molecules. Vinoxy radical can be separated into two fragments namely CH2 and HCO. Both of these have been detected in the interstellar medium. However, vinoxy radical is not yet detected in the interstellar medium. Two reaction channels have been studied for the reaction between CH2 and HCO in the gas phase and in the presence of one water molecule. Product of channel 1 is vinoxy radical while in channel 2, CO and CH3 are formed. Density functional theory (DFT) and complete active self-consistent field (CASSCF) calculations predict both the reactions to be barrierless. Therefore, non-detection of vinoxy radical cannot be explained on the basis of potential energy surface scans obtained by DFT and CASSCF calculations. However, study of frontier orbitals provides a reasonable explanation for the validity of channel 2 and prohibition of channel 1. Further, the Mulliken charge and electrostatic surface potential map also supports that the H atom of HCO will have higher probability of interacting with C atom of CH2 (formation of CH3 + CO via hydrogen abstraction) compared to the coupling of carbon-carbon atom (formation of vinoxy radical via C-C bonding).
Preparation and Investigation of PVA/Cu Nanoparticles by Eco-friendly Electrochemical Method
Authors: Fahmy Tarek , Habib Ahmed , Sarhan Afaf 
Published: February 2022

Abstract
Polyvinyl alcohol (PVA) /Cupper nanocomposite samples have been prepared electrochemically with different times of electropolymerization process. The characterization of prepared samples has been carried out using different techniques such as, X-ray diffraction, FTIR and UV-Vis spectroscopy. XRD patterns showed that, with increasing Cupper nanoparticles (CuNPs) content, the crystal size (D hkl) values are decreased whereas the internal strain values of PVA/Cu nanocomposite samples are increased, indicating that a crystal distortion and defects have been occurred in PVA matrix. FTIR spectroscopy revealed that the incorporation of CuNPs induced modifications in the PVA structure. The presence of the characteristic surface plasmon resonance peak at 773 nm in the absorption spectra of the PVA/CuNPs composite samples confirmed the formation of copper nanoparticles. Analysis of UV-Vis spectra showed that the indirect and direct optical bandgap energies of PVA/CuNPs samples decreased with increasing the CuNPs content. On the other hand, an increase in the refractive index of PVA is observed with increasing concentration of CuNPs. The decrease in the band gap and the increase in conductivity due to the formation of localized electronic states in the PVA host matrix due to the introduction of copper nanoparticles can be related.
Synthesis and Characterization of GaN/quartz Nanostructure using Pulsed Laser Ablation in Liquid
Authors: Fakhri Makram A , Amir Husam Aldin A. Abdul , Alwahib Ali. A. , Salim Evan T. , Alsultany Forat H. 
Published: February 2022

Abstract
This study involves synthesizing gallium nitride (GaN) nanoparticles (NPs) under six different ablation energies using the pulsed laser ablation method. The nanoparticle was deposited using drop cast method on a quartz substrate. XRD pattern shows two peaks of h-GaN nanoparticles at 2θ = 34.64 and 37.98, reflected from (002) and (100) planes. The morphological properties indicate the hexagonal crystal nature of GaN that shows in the XRD pattern. Photoluminescence (PL) spectra show the highest laser power, 2000 mj has a minor emission peaked at 3.34 eV. The maximum emission peak 3.83 eV at 1400 mJ. The study depends on the pulsed laser to generate nanoparticles with different characteristics.
Health Promotion and Empowerment in Collaboration: Theoretical Underpinnings and Methodological Challenges When Creating a Health Equity Program in a Vulnerable Area
Authors: Tengland Per-Anders , Rämgård Margareta 
Published: February 2022

Abstract
In Sweden, as in all other countries, there are inequalities in various areas, such as health and wealth. Research has established a social gradient in health, which means that socio-economic groups differ regarding health status. Furthermore, in many cities today there is segregation and some areas are more “socially vulnerable” than others. Some of these differences between groups and areas can be regarded as unjust and thus constitute inequities. The aim of this paper is to present the creation of a health-promotion innovation program whose purpose is to counteract health inequities in a “vulnerable” urban area in southern Sweden, and to discuss the theoretical and methodological foundations of the program. It does not, then, present any final health outcomes, but rather, gives a description of the, rather complex, initiation and launching of the program, which can in itself be seen as a kind of result. The research carried out in the program is Community-Based Participatory Research (CBPR), grounded in Participatory Action Research (PAR). The paper presents the CBPR program from its start to the present, including its rationale, and sets forth its theoretical underpinnings, i.e., ideas about place, empowerment, health promotion, “human nature,” communication and dialogue, and health equity. It closes by discussing some potential methodological and philosophical problems, namely, issues related to health equity, empowerment as a process, power relations, and community participation in the outcome evaluation.
Multi-locus genome-wide association study for phosphorus use efficiency in a tropical maize germplasm
Authors: Zeffa Douglas Mariani , Júnior Luiz Perini , Delfini Jéssica , Marcos Antoni Wallace , Koltun Alessandra , Baba Viviane Yumi , Constantino Leonel Vinícius , Nogueira Alison Fernando , Moda-Cirino Vania , Scapim Carlos Alberto , Gonçalves Leandro Simões Azeredo 
Published: February 2022

Abstract
Background and aim
Phosphorus (P) is an essential macronutrient for maize (Zea mays L.) growth and development. Therefore, generating cultivars with upgraded P use efficiency (PUE) represents one of the main strategies to reduce the global agriculture dependence on phosphate fertilizers. In this work, genome-wide association studies (GWAS) were performed to detect quantitative trait nucleotide (QTN) and potential PUE-related candidate genes and associated traits in greenhouse and field trials under contrasting P conditions.
Methods
The PUE and other agronomy traits of 132 inbred maize lines were assessed in low and normal P supply through the greenhouse and field experiments and Multi-locus GWAS was used to map the associated QTNs.
Results
Wide genetic variability was observed among the inbred maize lines under low and normal P supply. In addition, we confirm the complex and quantitative nature of PUE. A total of 306 QTNs were associated with the 24 traits evaluated using different multi-locus GWAS methods. A total of 186 potential candidate genes were identified, mainly involved with transcription regulator, transporter, and transference activity.
Conclusions
Further studies are still needed to elucidate the functions and relevance of these genes regarding PUE. Nevertheless, pyramiding the favorable alleles pinpointed in the present study can be considered an efficient strategy for molecular improvement to increase maize PUE.
Recruiting Males To The Nursing Profession: Acceptability Testing Of The ‘Make A Difference With Nursing’ Intervention For Post-Primary School Students.
Authors: Linden Mark Anthony , Mitchell Gary , Carlisle Susan , Rainey Debbie , Mulvenna Caroline , Monaghan Catherine 
Published: February 2022

Abstract
Background: The nursing profession is facing a worldwide recruitment shortage which could be partially addressed by recruiting more males. However, in many developed countries numbers of males nurses have traditionally been low. To address this issue we developed and tested a post-primary school-based intervention to recruit more males into the nursing profession. Methods: Thirty-four female students drawn from an all-girls post-primary school, fifty-one males from an all-boys post-primary school and seven males and fifteen females drawn from a mixed gender post-primary school, all located in Northern Ireland. Participants were all sixteen years of age and were in receipt of careers education. The intervention titled ‘Make a Difference with Nursing’ was co-designed with careers teachers, nurses and post-primary school students. This video based intervention was created to fit within existing career lessons and featured nursing staff and students describing their experiences of the profession. Participants completed the six domains of Nursing as a Career Choice Questionnaire prior to viewing the intervention and again after viewing. Results: Positive and statistically significant increases in perceptions of the nursing profession were found between pre and post test scores across all six domains. No statistically significant differences in perceptions were found between males and females after watching the intervention. Comparison by school type showed statistically significant differences on the domains of prior healthcare exposure (p=0.046; 95% CI -0.19 to 3.79) and job prospects (p=0.005; 95% CI 1.04 to 7.01). Students from the all-girls school rated these more positively than those from the all-boys and mixed-gender schools. Conclusions: A short video presentation to post-primary school students is capable of changing how they perceive the nursing profession. Students expressed surprise over the variety of professional nursing roles suggesting that many were not well informed about the realities of nursing. Providing tailored resources for use in careers lessons can better educate students and teachers about nursing and provide positive portrayals of male role models in the profession.
A comparison of Ivermectin and Non Ivermectin based regimen for covid 19 in Abuja: effects on virus clearance, Days-to-Discharge and Mortality.
Authors: Y Thairu , O.E. Babalola , Ajayi Adesuyi A , Y. Ndanusa. , J.O. Ogedengbe. , O. Omede. 
Published: February 2022

Abstract
Aim: To compare outcomes from ivermectin (IVM)- and non-ivermectin (NIVM)-based treatments for COVID-19 in Abuja, Nigeria.Methods: Sixty-one consecutive virology-proven cases were recruited and managed with IVM-based regimes. A subsequent cohort of 26 patients was treated with NIVM due to physician preference, with varying combinations of lopinavir/ritonavir (Alluvia), remdesivir, azithromycin, and enoxapramin. All patients received zinc sulfate, vitamin C and supportive therapy. Propensity matching was carried out as indicated, and Repeat Measures Analysis of Variance (RMANOVA) allowing for time*treatment interaction was carried out for time dependent variables, deriving Likelihood Ratio (LR) and P values.Main outcome measures: Change in cycle threshold (viral load) over time, positivity status by day 5, improvement in clinical status using myalgia scores, days to discharge (DTD), change in SpO2 and death. Results: IVM was associated with a greater and faster reduction in viral clearance (LR=64.2 p= 0.000 for the N gene): 31% and 95% were negative by days 5 and 14, respectively, versus 0% on NIVM. The mean DTD on IVM was 8.8 days versus 19.4 days, p= 0.000. IVM proved significantly superior for Myalgia scores, LR= 23.45, P=0.0007. The mortality rate was 0/61 (0%) in IVM but 4/26 (15.3%) in NIVM. Three of the 4 deaths were in females, and 2 had been vaccinated, one fully. The SP02% increased significantly more on IVM (p < 0.0001 RMANOVA) than the NIVM group. C-reactive protein and D-dimer levels dropped significantly more sharply during IVM (P= 0.0068, 0.063), suggesting anti-inflammatory and antifibrinolytic activity.Conclusions: The IVM-based regimen caused earlier discharge from treatment and reduced mortality, in addition to clinical and laboratory improvements. Vaccination did not protect some patients from SARS-CoV-2 breakthrough infection and mortality.
Fabrication of g-C3N4/ZnO Nanoheterostructures for Effective Degradation of Methylene Blue Dye under Visible Light Irradiation
Authors: MEENA PARMESHWAR LAL , Poswal Krishna , Surela Ajay Kumar , Saini Jitendra Kumar 
Published: February 2022

Abstract
In the present, the g-C3N4/ZnO hybrid nanoheterostructures photocatalysts with different weight percents of ZnO have been successfully prepared by a facile grinding, dehydration followed by pyrolysis method. The structural and textural properties of the prepared samples were investigated by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy combine electron dispersive spectroscopy (FESEM-EDS) and UV-vis spectroscopy. The photocatalytic performance of the fabricated g-C3N4/ZnO nanostructures was investigated for the degradation of methylene blue (MB) dye and it is determined much higher in compare to the bare g-C3N4 nanosheets and ZnO nanorods. The optimized ZnO content in the g-C3N4/ZnO photocatalyst was determined to be 25%. In the current study, 99.54% of MB dye is degraded in 60 min of visible light irradiation at pH = 10 over g-C3N4/ZnO (25%) photocatalyst. The results of the kinetic study reveals that photodegradation reactions have followed the first-order kinetics and the rate constant values of MB photodegradation in presence of prepared g-C3N4/ZnO (25%) is determined ∼13 and ∼7.76 times greater than that of the bare g-C3N4 and ZnO respectively. The enhanced photocatalytic efficiency of the fabricated g-C3N4/ZnO nanoheterostructures could be due to the creation of heterojunction by the coupling of two semiconductors of well matched band structures in which effective charge transfer has been occurred. The prepared g-C3N4/ZnO has demonstrated significant photostability after utilization in four runs of cycles. The decrease in the catalyst performance even after four repeated cycles is approximately 8%. The superoxide free radicals (•O2−) are the main reactive species participated in the degradation of MB dye. The current approach of fabrication of heterojunction has presented a competent and simplistic synthetic tactic of creation of visible-light-driven photocatalyst for the effective photocatalytic mineralization of organic dye contaminants in the aqueous medium.
Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway
Authors: de Souza Alana Gomes , Lopes Iardja Stéfane , Filho Adriano José Maia Chaves , Cavalcante Talita Matias Barbosa , Oliveira João Victor Souza , de Carvalho Michele Albuquerque Jales , de Lima Klistenes Alves , Jucá Paloma Marinho , Mendonça Sabrina Silva , Mottin Melina , Andrade Carolina Horta , de Sousa Francisca Cléa Florenço , Macedo Danielle S. , Fonteles Marta Maria de França 
Published: February 2022

Abstract
We postulated that dimethyl fumarate (DMF), an activator of the Nuclear Factor Erythroid 2-related factor 2 (Nrf2) pathway, exerts neuroprotective effects against depression-like behaviors through astrocytes and microglia modulation. To ascertain our hypothesis and define the mechanistic pathways involved in effect of DMF on neuroinflammation, we used the depression model induced by Chronic Unpredictable Mild Stress (CUMS), in which, the mice were exposed to stressful events for 28 days and from the 14th day they received DMF in the doses of 50 and 100 mg / kg or fluoxetine 10 mg / kg or saline. On the 29th day, the animals were subjected to behavioral tests. Microglia (Iba1) and astrocytes (GFAP) markers expressions were evaluated by immunofluorescence analyzes and the cytokines TNF-α and IL-Iβ by immunoenzymatic assay. In addition, computational target prediction, 3D protein structure prediction and docking calculations were performed with monomethyl fumarate (DMF active metabolite) and the Kelch-like ECH associated protein-1 and hydroxycarboxylic acid receptor 2 (HCAR2), which suggested that these could be the probable targets related protective effects. CUMS induced anxiety- and depressive-like behaviors, cognitive deficit, decreased GFAP and increased Iba1, TNF-α and IL-Iβ expression in the hippocampus. These alterations were reversed by DMF. Thus, it is suggested that one of the mechanisms involved in the antidepressant effect of DMF is neuroinflammatory suppression, through the signaling pathway HCAR2 / Nrf2. However, more studies must be performed to better understand the molecular mechanisms of this drug.
Particulate Matter Exposure-Induced Cholesterol Metabolism Disorder In Lung Epithelial Cells
Authors: Yin Ting , Liu Yuanyuan , Cong Xiaonan , Ding Rui , Diao Zhenying , Qiu Long , Wu Haigang 
Published: February 2022

Abstract
Background: Particulate matter (PM) has been the worldwide problem to threaten human health. Although many work have well investigated physiological effect of PM on different tissues, few work can systemically evaluate intrinsic molecular mechanism of PM effect at molecular pathway levels and how to lead cellular toxicity.Methods: Here, RNA sequencing was employed to explore molecular mechanism of micro-meter PMs obtained from air on ferret lung epithelial cells. PM particles were firstly characterized using SEM, XPS and IR to examine morphology and elemental components. Then, dosage-dependent cellular toxicity of PM was examined using MTT method, and it displayed dosage-dependent cellular apoptosis. Results: By performing bioinformatics analysis, we found that 190 down-regulated and 56 up-regulated genes were identified after exposure to PM particles with higher concentration (500 μg/mL). By employing gene ontology (GO) and gene score enrichment analysis (GSEA), results demonstrated that “cholesterol metabolism” pathway was substantially down-regulated, which was confirmed using qRT-PCR and free cholesterol measurement. The intrinsic mechanism to lead dysfunction of cholesterol metabolism is oxidative stress with imbalance of GSSH/GSH and NADP/NADPH ratios, leading by higher ROS and disorder of mitochondrial membrane potential. Conclusion: These results give a new insight in physiological effect of PMs on lung epithelial cells and provide the potential intervention approaches to rescue respiratory-related diseases caused by exposure to particulate matters.
Effectiveness of Emotion Regulation Strategies in Dealing With Weak and Strong Negative Emotion: Self-report, Heart Rate Variability, and Electromyography Data
Authors: Kobylińska Dorota , Lewczuk Karol , Wizła Magdalena , Marcowski Przemysław , Blaison Christophe , Kastendieck Till , Hess Ursula 
Published: February 2022

Abstract
We investigated how emotion regulation (ER) effectiveness – both on a level of self-reported rating as well as emotional expression (corrugator supercilii muscle activity) – is affected by the characteristics of the situation (low vs. high negativity), the strategy used (reappraisal, distraction, suppression, no regulation control condition) and individual dispositions (low vs. high baseline Heart Rate Variability) as well as their interaction. For this 69 adult women participated in a laboratory study. All the included factors significantly influenced both corrugator activity and appraisals of pictures’ negativity (in specific experimental conditions). For example, for high HRV participants, (1) distraction, suppression and reappraisal significantly decreased corrugator activity compared to the control condition, and (2) distraction as well as reappraisal decreased appraised picture negativity for high negativity photos. For low HRV participants, distraction and suppression were most effective in decreasing corrugator responses, while suppression was more effective than reappraisal in decreasing perceived picture negativity in the low negativity condition. Subjectively reported effort and success in applying ER strategies were also dependent on manipulated and dispositional factors. Overall, our results lend support to the flexible emotion regulation framework, showing that emotion regulation effectiveness relies on situational context as well as individual dispositions and their interaction.