bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of Hip Arthroplasty and Closed Reduction Proximal Femur Nail in the Treatment of Elderly Patients with Hip Fractures
Authors: Zhou Xianchao , Shen Xiang 
Published: May 2022

ObjectiveTo compare the clinical effect of hip arthroplasty and closed reduction intramedullary nailing of proximal femur in the treatment of elderly hip fracture patients.MethodsThere are 90 elderly hip fracture patients being recruited in the present study. Fifty patients in Group A received closed reduction intramedullary nailing of proximal femur, and 40 patients in Group B received hip arthroplasty. All patients were followed up for 12 months after surgery, clinical outcomes included surgical indicators, visual analog scale (VAS) score, Harris score, quality of life, mental status, and complications.ResultsThe surgery time, bleeding volume, infusion volume of patients in Group A are all significantly lower than those in Group B (p &lt; 0.05), while the weight-bearing activity time and first workout time of Group A are all significantly higher than those in Group B (p &lt; 0.05). The VAS score in patients of Group A at 1 week postoperative is significantly lower than that in patients of Group B (p &lt; 0.05). The Harris score in patients of Group A at 3, 6, and 12 months postoperative are all significantly higher than those in patients of Group B (p &lt; 0.05), and the excellent and good rate of hip function recovery at 12 months postoperative in patient of Group A is significantly lower than that in patients of Group B (80% vs. 95%, p &lt; 0.05). Furthermore, The score of SF-36 standardized physical component, SF-36 standardized mental component and Barthel in patients of Group A at 6 months postoperative are significantly lower than those in patients of Group B (p &lt; 0.05), and the score of mini-mental state examination is significantly higher (p &lt; 0.05), while there are not significantly different at 12 months postoperative (p &gt; 0.05). The incidence of postoperative complications in Group A was significantly lower than that in Group B (10% vs. 27.5%, p &lt; 0.05).ConclusionElderly hip fracture patients treated with closed reduction intramedullary nailing of proximal femur has less surgical trauma and lower complication rates, but slower postoperative recovery compared with hip arthroplasty.
Gene Expression Profile Analysis of Human Epidermal Keratinocytes Expressing Human Papillomavirus Type 8 E7
Authors: Chen Xianzhen , Li Ma , Tang Yi , Liang Qichang , Hua Chunting , He Huiqin , Song Yinjing , Cheng Hao 
Published: May 2022

Background: Human papillomavirus type 8 (HPV8) has been implicated in the progress of non-melanoma skin cancers and their precursor lesions. The HPV8 E7 oncoprotein plays a key role in the tumorigenesis of HPV-associated cutaneous tumors. However, the exact role of HPV8 E7 in human epidermal carcinogenesis has not been fully elucidated.Methods: To investigate the potential carcinogenic effects of HPV8 E7 on epithelial cells, we used RNA-sequencing technology to analyze the gene expression profile of HPV8 E7-overexpressed normal human epidermal keratinocytes (NHEKs).Results: RNA-sequencing revealed 831 differentially expressed genes (DEGs) between HPV8 E7-expressing NHEKs and control cells, among which, 631 genes were significantly upregulated, and 200 were downregulated. Gene ontology annotation enrichment analysis showed that HPV8 E7 mainly affected the expression of genes associated with protein heterodimerization activity, DNA binding, nucleosomes, and nucleosome assembly. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that overexpression of HPV8 E7 affected the expression of gene clusters associated with viral carcinogenesis and transcriptional misregulation in cancer and necroptosis signaling pathways that reportedly play crucial roles in HPV infection promotion and cancer progression. We also found the DEGs, such as HKDC1 and TNFAIP3, were associated with epigenetic modifications, immune regulation, and metabolic pathways.Conclusion: Our results demonstrate that the pro-carcinogenic effect of HPV8 expression in epithelial cells may be attributed to the regulatory effect of oncogene E7 on gene expression associated with epigenetic modifications and immune and metabolic status-associated gene expression. Although our data are based on an in vitro experiment, it provides the theoretical evidence that the development of squamous cell carcinoma can be caused by HPV.
Distribution and Clinical Significance of IL-17A in Tumor-Infiltrating Lymphocytes of Non-Small Cell Lung Cancer Patients
Authors: Xu Rui , Ke Xing , Shang Wenwen , Liu Shuna , Fu Xin , Wang Ting , Jin Shuxian 
Published: May 2022

Objective: To investigate the distribution of IL-17A and its clinical significance in tumor infiltrating lymphocytes (TILs) of patients with non-small cell lung cancer (NSCLC).Methods: Expression level of IL-17A in TILs of 3 paired NSCLC and paracancerous specimens was measured by qRT-PCR. The distribution of IL-17A in immune cell subsets of 15 paired NSCLC and paracancerous specimens was examined by flow cytometry. The correlation between IL-17A and clinical features of NSCLC was identified.Results: IL-17A was significantly upregulated in TILs of NSCLC specimens than those of paracancerous ones (p &lt; 0.0001). Meanwhile, T helper 17 cells (Th17 cells, p &lt; 0.001), IL-17-secreting CD8+ T cells (Tc17 cells, p &lt; 0.001) and IL-17-producing cells (γδT17 cells, p &lt; 0.0001) were significantly abundant in TILs of NSCLC specimens than those of controls, and the higher abundance of the latter was much pronounced than that of the former two. Moreover, γδT17 cells in TILs were significantly correlated with lymphatic metastasis and CYFRA 21-1 level of NSCLC patients (p &lt; 0.05).Conclusion: Tumor infiltrated γδT cells are the main source of IL-17 in early-stage NSCLC, and IL-17 may be a vital regulator involved in the development of NSCLC.
Donor-Derived Cell-Free DNA for the Detection of Heart Allograft Injury: The Impact of the Timing of the Liquid Biopsy
Authors: Verhoeven Jeroen G. H. P. , Hesselink Dennis A. , Peeters Annemiek M. A. , de Jonge Evert , von der Thüsen Jan H. , van Schaik Ron H. N. , Matic Maja , Baan Carla C. , Manintveld O. C. , Boer Karin 
Published: May 2022

Background: In heart transplant recipients, donor-derived cell-free DNA (ddcfDNA) is a potential biomarker for acute rejection (AR), in that increased values may indicate rejection. For the assessment of ddcfDNA as new biomarker for rejection, blood plasma sampling around the endomyocardial biopsy (EMB) seems a practical approach. To evaluate the effect of the EMB procedure on ddcfDNA values, ddcfDNA values before the EMB were pairwise compared to ddcfDNA values after the EMB. We aimed at evaluating whether it matters whether the ddcfDNA sampling is done before or after the EMB-procedure.Methods: Plasma samples from heart transplant recipients were obtained pre-EMB and post-EMB. A droplet digital PCR method was used for measuring ddcfDNA, making use of single-nucleotide polymorphisms that allowed both relative quantification, as well as absolute quantification of ddcfDNA.Results: Pairwise comparison of ddcfDNA values pre-EMB with post-EMB samples (n = 113) showed significantly increased ddcfDNA concentrations and ddcfDNA% in post-EMB samples: an average 1.28-fold increase in ddcfDNA concentrations and a 1.31-fold increase in ddcfDNA% was observed (p = 0.007 and p = 0.03, respectively).Conclusion: The EMB procedure causes iatrogenic injury to the allograft that results in an increase in ddcfDNA% and ddcfDNA concentrations. For the assessment of ddcfDNA as marker for AR, collection of plasma samples before the EMB procedure is therefore essential.
Ab Initio Study on Dopant Relaxation Mechanism in Ti and Ce Cationically Substituted in Wurtzite Gallium Nitride
Authors: Alkhedher Mohammad , Majid Abdul , Bulut Niyazi , Elkhatib Samah Elsayed 
Published: May 2022

The changes in properties of materials upon introduction of impurities is well documented but less is known about the location of foreign atoms in different hosts. This study is carried out with the motivation to explore dopant location in hexagonal GaN using density functional theory based calculations. The dopant site location of the individual dopants Ti, Ce, and Ti-Ce codoped wurtzite GaN was investigated by placing the dopants at cationic lattice sites as well as off-cationic sites along the c-axis. The geometry optimization relaxed individual dopants on cationic Ga sites but in the case of codoping Ce settled at site 7.8% away along [0001 ¯] and Ti adjusted itself at site 14% away along [0001] from regular cationic sites. The analysis of the results indicates that optimized geometry is sensitive to the starting position of the dopants. The magnetic exchange interactions between Ti and Ce ions are responsible for their structural relaxation in the matrix.
FORMATION OF A RISK IDENTIFICATION AND MANAGEMENT SYSTEM FOR FINANCIAL INSTITUTIONS
Authors: Магомаева Л. Р. 
Published: May 2022

В связи с активным внедрением мер социального дистанцирования на фоне распространения COVID-19, внимание научного сообщества сконцентрировано на исследованиях применения цифровых, бесконтактных финансовых технологий обслуживания клиентов. Риски, связанные с распространением COVID-19, открывают проблемы неформальной занятости, развитие которых обусловлено преимущественно сокращением рабочих мест, отсутствием социальных гарантий и снижением размера заработной платы. Кредитно-финансовый сектор является наиболее чувствительным к воздействию рисков, обусловленных влиянием пандемии, поскольку аккумулируемые в нем финансовые расчеты и транзакции усиливают рост преступлений, связанных с легализацией доходов, полученных преступным путем. Данная статья раскрывает особенности формирования комплексной системы идентификации рисков COVID-19 для организаций кредитно-финансовой сферы в условиях развития дистанционных каналов обслуживания. В ходе проведенного исследования автором было установлено, что: достижение максимального эффекта от внедряемой системы идентификации рисков COVID-19 в масштабе многофилиальной кредитно-финансовой организации обеспечивается путем анализа событий и источников на уровне различных операционных и бизнес-процессов в рамках последующей оценки потенциальных угроз и идентификации наиболее значимых из них.
Due to the active implementation of social distancing measures against the background of the spread of COVID-19, the attention of the scientific communityis focusedonresearchontheuse of digital, contactless financial technologies for customer service. The risks associated with the spread of COVID-19 open up problems of informal employment, the development of which is mainly due to the reduction of jobs, lack of social guarantees and a decrease in wages. The financial and credit sector is the most sensitive to the impact of risks associated with the impact of the pandemic, since the accumulated financial settlements and transactions in it increase the growth of crimes related to the legalization of proceeds from crime.This article reveals the features of the formation of a comprehensive COVID-19 risk identification system for organizations in the credit and financial sector in the context of the development of remote service channels. In the course of the study, the author found that: achieving the maximum effect from the implemented COVID-19 risk identification system on the scale of a multi-branch financial institution is ensured by analyzing events and sources at the level of various operational and business processes as part of the subsequent assessment of potential threats and identification the most significant of them.
IMPLEMENTASI SCRUM PADA FRAMEWORK SISTEM INFORMASI PENJUALAN DAN PEMBELIAN CAT PADA TOKO CAD
Authors: Eriana Emi Sita 
Published: May 2022

ABSTRACT

In the business world in the company's time that applies information technology because technology is needed in the world of work to facilitate in completing a job so that it is more effective and efficient. One example of the development of information technology in the world of work or the business world is data processing systems. In case studies in cad business units still use manual recording, the management and input process is still manual so it is less effective, efficient, and there are errors in recording inaccurately. Peneliti designed a web-based paint sales and purchase application where this application can facilitate the sale and purchase of paint without location limitations. This method in design uses the Agile method with its continuous development in a process called Scrum that overcomes complexity in the work by making it easier to understand and transparent, allowing teams to examine and adapt depending on current conditions, not the predicted scenario. The implementation of the scrum method is built with framework and MySQL databases. Hasil from research system sales and purchase of web-based paints facilitates purchases, so that customers can make purchases through the website indefinitely, where customers can buy and transact and make it easier for admins to make sales, with this paint sales and purchase system to support a wider market reach without location limitations.

Keywords: Implementation, Scrum method, Framework, Design, Sales System
The Population of Compact Radio Sources in M17
Authors: Yanza Vanessa , Masqué Josep M. , Dzib Sergio A. , Rodríguez Luis F. , Medina S.-N. X. , Kurtz Stan , Loinard Laurent , Trinidad Miguel A. , Menten Karl M. , Rodríguez-Rico Carlos A. 
Published: May 2022

Abstract
We present a catalog of radio sources of the M17 region based on deep X-band radio observations centered at 10 GHz obtained with the Jansky Very Large Array in the A configuration. We detect a total of 194 radio sources, 12 of them extended and 182 compact. We find that a significant fraction (at least 40% in our catalog) have suspected gyrosynchrotron emission associated with stellar coronal emission. By comparing the radio luminosities of our sources with their X-ray counterparts, when available, we find that they are underluminous in X-rays with respect to the Güdel–Benz relation, but a correlation with a similar slope is obtained provided that only sources with evident nonthermal nature are selected from the sample compiled for the Orion Nebula Cluster (ONC) and M17. The comparison of M17 with the ONC and NGC 6334D-F leads to a similar luminosity function for the three regions, at least for the more luminous sources. However, the radio sources in M17 are three times more numerous compared to the other regions at a given luminosity and their spatial distribution differs from that of Orion. Moreover, an arc-shaped structure of 40″ in extent is observed in our map, identified previously as an ionizing front, with the cometary hypercompact source UC1 at its focus. Archival 1 mm ALMA data reveals compact emission coincident with the radio wavelength peak, possibly associated with a protostellar disk of the massive star exciting UC1.
Secular Dynamics around a Supermassive black hole via Multipole Expansion
Authors: Fouvry Jean-Baptiste , Dehnen Walter , Tremaine Scott , Bar-Or Ben 
Published: May 2022

Abstract
In galactic nuclei, the gravitational potential is dominated by the central supermassive black hole, so stars follow quasi-Keplerian orbits. These orbits are distorted by gravitational forces from other stars, leading to long-term orbital relaxation. The direct numerical study of these processes is challenging because the fast orbital motion imposed by the central black hole requires very small timesteps. An alternative approach, pioneered by Gauß, is to use the secular approximation of smearing out N stars over their Keplerian orbits, using K nodes along each orbit. In this study, we propose three novel improvements to this method. First, we reformulate the discretization of the rates of change of the variables describing the orbital states to ensure that all conservation laws are exactly satisfied. Second, we replace the pairwise sum over nodes by a multipole expansion up to order

ℓ

max

, reducing the overall computational cost from O(N
2
K
2) to

O
(
NK

ℓ

max

2

)

. Finally, we show that the averaged dynamical system is equivalent to 2N interacting unit spin vectors and provide two time integrators: a second-order symplectic scheme, and a fourth-order Lie-group Runge–Kutta method, both of which are straightforward to generalize to higher order. These new simulations recover the diffusion coefficients of stellar eccentricities obtained through analytical calculations of the secular dynamics.
Two Rings and a Marginally Resolved, 5 au Disk around LkCa 15 Identified via Near-infrared Sparse Aperture Masking Interferometry
Authors: Blakely Dori , Francis Logan , Johnstone Doug , Soulain Anthony , Tuthill Peter , Cheetham Anthony , Sanchez-Bermudez Joel , Sivaramakrishnan Anand , Dong Ruobing , van der Marel Nienke , Cooper Rachel , Vigan Arthur , Cantalloube Faustine 
Published: May 2022

Abstract
Sparse aperture masking interferometry (SAM) is a high-resolution observing technique that allows for imaging at and beyond a telescope’s diffraction limit. The technique is ideal for searching for stellar companions at small separations from their host star; however, previous analyses of SAM observations of young stars surrounded by dusty disks have had difficulties disentangling planet and extended disk emission. We analyze VLT/SPHERE-IRDIS SAM observations of the transition disk LkCa 15, model the extended disk emission, probe for planets at small separations, and improve contrast limits for planets. We fit geometrical models directly to the interferometric observables and recover previously observed extended disk emission. We use dynamic nested sampling to estimate uncertainties on our model parameters and to calculate evidences to perform model comparison. We compare our extended disk emission models against point-source models to robustly conclude that the system is dominated by extended emission within 50 au. We report detections of two previously observed asymmetric rings at ∼17 and ∼45 au. The peak brightness location of each model ring is consistent with the previous observations. We also, for the first time with imaging, robustly recover an elliptical Gaussian inner disk, previously inferred via SED fitting. This inner disk has an FWHM of 5 au and a similar inclination and orientation to the outer rings. Finally, we recover no clear evidence for candidate planets. By modeling the extended disk emission, we are able to place a lower limit on the near-infrared companion contrast of at least 1000.
Establishing the Nonprimordial Origin of Black Hole–Neutron Star Mergers
Authors: Sasaki Misao , Takhistov Volodymyr , Vardanyan Valeri , Zhang Ying-li 
Published: May 2022

Abstract
Primordial black holes (PBHs) from the early universe constitute attractive dark matter candidates. First detections of black hole–neutron star (BH–NS) candidate gravitational wave events by the LIGO/Virgo collaboration, GW200105 and GW200115, already prompted speculations about nonastrophysical origin. We analyze, for the first time, the total volumetric merger rates of PBH–NS binaries formed via two-body gravitational scattering, finding them to be subdominant to the astrophysical BH–NS rates. In contrast to binary black holes, a significant fraction of which can be of primordial origin, either formed in dark matter halos or in the early universe, PBH–NS rates cannot be significantly enhanced by contributions preceding star formation. Our findings imply that the identified BH–NS events are of astrophysical origin, even when PBH–PBH events significantly contribute to the gravitational wave observations.
Measurement of the Charge Exchange Cross Section for N7+, O7+ Ions in Collision with Atomic H
Authors: Zhang R. T. , Seely D. G. , Andrianarijaona V. M. , Draganić I. N. , Havener C. C. 
Published: May 2022

Abstract
The absolute total cross sections for the charge exchange between highly charged ions 15N7+, O7+, and atomic H have been measured with the ion-atom merged-beams apparatus at Oak Ridge National Laboratory. The collision energy range is from 1224 down to 2 eV u−1, which covers outflowing hot components of astrophysical charge exchange plasmas like stellar-wind and supernova remnants. Good agreement with the previous measurements and theory is found for the collision energies above 100 eV u−1, while below 100 eV u−1 limited agreement is achieved with the available calculations. These cross-section data are useful for modeling X-ray emission resulting from the charge exchange at the interface of hot plasma interacting with ambient neutral gas.
Trouble développemental du langage et trouble spécifique d’apprentissage de la lecture : rôle du vocabulaire et de la compréhension écrite
Authors: Talli Ioanna 
Published: May 2022

L’article s’intéresse à la spécificité des déficits linguistiques chez les enfants présentant un trouble développemental du langage (TDL) et/ou un trouble spécifique d’apprentissage de la lecture (TSAL). Un premier objectif est de présenter l’état actuel des connaissances sur le rôle du vocabulaire dans le TDL et le TDLE. Celui-ci a un double impact : d’une part, sur la compréhension écrite, d’autre part, sur les procédures d’identification des mots écrits. Un second objectif est de suggérer que certaines différences relevées entre les enfants présentant un TDL ou un TSAL proviennent de choix méthodologiques. C’est ainsi que, dans les études sur le TSAL, le niveau de vocabulaire est une variable de contrôle, supposée ne pas différencier le groupe des enfants avec TSAL de celui des lecteurs typiques, et les évaluations portent alors le plus souvent sur les procédures d’identification des mots écrits. En revanche, c’est le niveau de compréhension du langage oral (du mot, à la phrase et au texte) qui est au centre des études sur les TDL. On peut donc penser que le vocabulaire et la compréhension écrite sont des variables pertinentes qu’il conviendrait de prendre en compte dans la compréhension de ces deux troubles.
Discours sur la démence et le déclin au Royaume-Uni
Authors: Libert Sébastien , Charlesworth Georgina , Higgs Paul 
Published: May 2022

La notion d’indépendance occupe une place prépondérante dans les stratégies actuelles de réponse à l’exclusion sociale des personnes atteintes de démence au Royaume-Uni, s’inscrivant dans un récit plus large de « bien vivre » dans la maladie. Cet article explore les implications pratiques de l’application de cette notion. Il se base sur une étude de six entretiens qualitatifs avec des chercheurs développant une intervention psychosociale dans ce pays. Une analyse de leurs perspectives et expériences présente comment l’application de ce concept vise à promouvoir une agentivité et un mode de vie actif chez la personne vivant un déclin cognitif. Cette intervention traduit ainsi un récit de stabilisation de la démence à l’encontre de sa nature progressive. Deux zones de tension émergent de ce récit dans l’intervention liées 1) à la normativité attachée au principe d’indépendance, et 2) au risque de présenter la dépendance comme un choix. Au vu de ces tensions, cet article argumente que la prédominance de ce principe d’indépendance risque de naturaliser une part de l’exclusion que vivent les personnes ne pouvant prendre part à ce type d’intervention en raison même de l’intensité de leur dépendance. Cet article propose alors le concept de techniques d’omission comme catégorie analytique permettant d’appréhender de manière plus large les interventions, stratégies et récits sociétaux qui omettent la position des personnes en situation de dépendance avancée, incitant ainsi une réflexion sur notre rapport sélectif au déclin cognitif et au vieillissement dans la société.