bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Dive Into Compassion
Authors: Lucarini Alice , Fuochi Giulia , Voci Alberto 
Published: June 2022

Abstract: The present multi-sample study ( N = 723) explores in depth the construct of dispositional compassion and its assessment, relying on two recent multidimensional scales: the Sussex-Oxford Compassion Scale – toward Others (SOCS-O; Gu et al., 2020 ) and the Compassion Scale (CS; Pommier et al., 2020 ). First, we validated the two scales in Italian, finding substantial support for their original factor structures and second-order solutions aggregating first-order factors into a general dispositional compassion factor. Second, we tested the simultaneous links between SOCS-O and CS facets via network analysis to identify which facets stand at the core of dispositional compassion or are more distal. Kindness (CS) and Feeling (SOCS-O) facets were more central components of compassion, leaning on the ability to tune in to (CS Mindfulness) and understand others’ pain (SOCS-O Universality) and connected to the urge to alleviate that pain (SOCS-O Acting). Third, we explored the nomological net of correlates of dispositional compassion and examined the differences between the SOCS-O and the CS in their relationship with the correlates. Results supported the convergent and discriminant validity of the scales and showed that the SOCS-O, compared to the CS, may capture some emotionally aversive sides of compassion.
Dynamics of Pedogenic Carbonate Growth in the Tropical Domain of Myanmar
Authors: Licht A. , Kelson J. , Bergel S. , Schauer A. , Petersen S. V. , Capirala A. , Huntington K. W. , Dupont‐Nivet G. , Win Zaw , Aung Day Wa 
Published: June 2022

AbstractPedogenic carbonate is widespread at mid latitudes where warm and dry conditions favor soil carbonate growth from spring to fall. The mechanisms and timing of pedogenic carbonate formation are more ambiguous in the tropical domain, where long periods of soil water saturation and high soil respiration enhance calcite dissolution. This paper provides stable carbon, oxygen and clumped isotope values from Quaternary and Miocene pedogenic carbonates in the tropical domain of Myanmar, in areas characterized by warm (>18°C) winters and annual rainfall up to 1,700 mm. We show that carbonate growth in Myanmar is delayed to the driest and coldest months of the year by sustained monsoonal rainfall from mid spring to late fall. The range of isotopic variability in Quaternary pedogenic carbonates can be solely explained by temporal changes of carbonate growth within the dry season, from winter to early spring. We propose that high soil moisture year‐round in the tropical domain narrows carbonate growth to the driest months and makes it particularly sensitive to the seasonal distribution of rainfall. This sensitivity is also enabled by high winter temperatures, allowing carbonate growth to occur outside the warmest months of the year. This high sensitivity is expected to be more prominent in the geological record during times with higher temperatures and greater expansion of the tropical realm. Clumped isotope temperatures, δ13C and δ18O values of tropical pedogenic carbonates are impacted by changes of both rainfall seasonality and surface temperatures; this sensitivity can potentially be used to track past tropical rainfall distribution.
Wind‐Driven Currents in a “Wide” Narrow Channel, With Application to Douglas Channel, BC
Authors: Wan Di , Hannah Charles G. , Cummins Patrick F. , Foreman Michael G. G. , Dosso Stan E. 
Published: June 2022

AbstractThis paper applies a structured grid, 3‐Dimensional Regional Ocean Modeling System to examine wind‐driven currents of an idealized stratified channel, representative of Douglas Channel, British Columbia, Canada, where the increased marine activities require an improved understanding of the physical oceanography. The surface along‐channel elevation slope resulting from the wind stress is strongly affected by the surface stratification and can serve as a proxy for gauging surface stratification in operational systems. In the case of strong surface stratification, due to rotational effects an apparently narrow (width ≪ length) channel can be dynamically wide with pronounced cross‐channel variation. The thickness of the surface wind‐driven layer is scaled using the thermal wind relation, which provides a scaling factor to estimate the thickness of the surface layer. This scaling factor is not restricted to the wind‐driven flow and could be expanded to the surface mean estuarine outflow layers.
Association of genetic variants with patient reported quality of life and pain experience in patients in the UK NCRI Myeloma X Relapse [Intensive]) trial; an exploratory study
Authors: Snowden John A. , Ahmedzai Sam H. , Cox Angela , Cairns David A. , Ashcroft A. John , Williams Cathy , Cavenagh Jamie D. , Hockaday Anna , Brown Julia M. , Brock Ian W. , Morris Treen C. M. , Cook Gordon ,   on behalf of the National Cancer Research Institute Haemato-oncology Clinical Studies Group
Published: June 2022

AbstractThe Myeloma X trial provided a platform to explore genetics in relation to systematic assessment of patient-reported outcomes at key points during salvage treatment in multiple myeloma (MM) patients. Blood DNA was obtained in 191 subjects for single nucleotide polymorphism (SNP) genotyping. By univariable analysis, the non-coding rs2562456 SNP, upstream of LINC00664, was associated with several relevant pain and health-related quality-of-life (HRQoL) scores at 100 days after allocation to consolidation with autologous stem cell transplantation or weekly cyclophosphamide. Presence of the minor (C) allele was associated with lower pain interference (p = 0.014) and HRQoL pain (p = 0.003), and higher HRQoL global health status (p = 0.011) and physical functioning (p = 0.007). These effects were not modified by treatment arm and were no longer significant at 6 months. Following induction therapy, the rs13361160 SNP near the CCT5 and FAM173B genes was associated with higher global health (p = 0.027) and physical functioning (p = 0.013). This exploratory study supports associations between subjective parameters in MM with SNPs previously identified in genome-wide association studies of pain. Conversely, SNPs in candidate genes involved in opioid and transporter pathways showed no effect. Further studies are warranted in well-defined cancer populations, and potentially assisted by whole genome sequencing with germline analysis in routine diagnostics in haematological cancers.
CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease
Authors: Ni Chao , Qiu Huixian , Zhang Shuchi , Zhang Qihao , Zhang Ruiyin , Zhou Jinhui , Zhu Jinshun , Niu Chao , Wu Rongzhou , Shao Chuxiao , Mamun Abdullah Al , Han Bo , Chu Maoping , Jia Chang 
Published: June 2022

AbstractEndothelial-to-mesenchymal transition (EndMT) is implicated in myofibroblast-like cell-mediated damage to coronary artery wall of Kawasaki disease (KD) patients, which subsequently increases the risk of coronary artery aneurysm. Many circular RNAs (circRNAs) have been reported to be associated with cardiovascular diseases. However, the roles and underlying molecular mechanism of circRNAs in KD-associated EndMT remains indefinite. In this research, we screened out circRNA-3302 from human umbilical vein endothelial cells (HUVECs) treated by sera from healthy controls (HCs) or KD patients via circRNA sequencing (circRNA-seq). In addition, circRNA-3302 upregulation was verified in endothelial cells stimulated by KD serum and pathological KD mice modeled with Candida albicans cell wall extracts (CAWS). Moreover, in vitro experiments demonstrated that overexpression of circRNA-3302 could markedly induce EndMT, and silencing of circRNA-3302 significantly alleviated KD serum-mediated EndMT. To further explore the molecular mechanisms of circRNA-3302 inducing EndMT, RNA sequencing (RNA-seq), a dual-luciferase reporter system, nuclear and extra-nuclear RNA isolation, RT-qPCR and Western blot analyses and so on, were utilized. Our data demonstrated that circRNA-3302 contributed to the KD-associated EndMT via sponging miR-135b-5p to enhance KIT expression. Collectively, our results imply that circRNA-3302 plays an important role in KD-associated EndMT, providing new insights into minimizing the risks of developing coronary artery aneurysms.
The importance of molecular weight in determining the minimum dose of oat β-glucan required to reduce the glycaemic response in healthy subjects without diabetes: a systematic review and meta-regression analysis
Authors: Noronha Jarvis C. , Zurbau Andreea , Wolever Thomas M. S. 
Published: June 2022

AbstractTo determine the minimum amount of oat β-glucan (OBG) required to reduce glycaemic responses (MinDose), we conducted a systematic review and meta-regression analysis of acute, crossover, single-meal feeding trials that examined the effects of adding OBG or oat bran to a carbohydrate-containing test-meal versus a control test-meal containing an equivalent amount of available-carbohydrate (avCHO) from the same or similar source. Medline, Embase, and Cochrane Library were searched up to 18 August 2021. The primary outcome was glucose incremental-area-under-the-curve (iAUC). Secondary outcomes included insulin iAUC, and glucose and insulin incremental peak-rise (iPeak). Two independent reviewers extracted data. Results were expressed as ratio-of-means (RoM) with 95% confidence intervals (CIs). Linear associations were assessed by random effects meta-regression. MinDose was defined as the dose at which the upper 95% CI of the regression line cut the line of no effect (i.e., RoM = 1). Fifty-nine comparisons (n = 340) were included; 57 in healthy subjects without diabetes and two in subjects with diabetes; 24 high-MW (>1000 kg/mol), 22 medium-MW (300–1,000 kg/mol), and 13 low-MW (<300 kg/mol). In healthy subjects without diabetes the associations between OBG dose and glucose iAUC and iPeak were linear (non-linear p value >0.05). MinDoses for glucose iAUC for high-MW, medium-MW and low-MW OBG, respectively, were estimated to be 0.2 g, 2.2 g and 3.2 g per 30 g avCHO; MinDoses for glucose iPeak were less than those for iAUC. Insufficient data were available to assess MinDose for insulin, however, there was no evidence of a disproportionate increase in insulin. More high-quality trials are needed to establish MinDose in individuals with diabetes.
A novel HRAS c.466C>T p.(Phe156Leu) variant in two patients with attenuated features of Costello syndrome
Authors: Lindsey-Temple Suzanna , Edwards Matt , Rickassel Verena , Nauth Theresa , Rosenberger Georg 
Published: June 2022

AbstractCostello syndrome (CS) is caused by heterozygous HRAS germline mutations. Most patients share the HRAS variant p.Gly12Ser that is associated with a typical, homogeneous phenotype. Rarer pathogenic HRAS variants (e.g., p.Thr56Ile) were identified in individuals with attenuated CS phenotypes. The obvious phenotypical variability reflects different dysfunctional consequences of distinct HRAS variants. We report on two boys with the novel de novo HRAS variant c.466 C > T p.(Phe156Leu). Both had severe feeding difficulties, airway obstruction and developmental delay, which are typical findings in CS. They showed subtle facial and dermatologic features consistent with attenuated CS. They significantly differed in their musculoskeletal, cardiovascular and endocrinologic manifestations underscoring the clinical variability of individuals with identical, in particular rarer pathogenic HRAS variants. Functional studies revealed enhanced effector-binding, increased downstream signaling activation and impaired growth factor-induced signaling dynamics in cells expressing HRASPhe156Leu. Our data further illustrate the molecular and phenotypic variability of CS.
Bidirectional mechanical switching window in ferroelectric thin films predicted by first-principle-based simulations
Authors: Liu Jianyi , Chen Weijin , Wu Mengjun , Sun Fei , Huang Xiang , Zheng Yue 
Published: June 2022

AbstractMechanical control of ferroelectric domain evolution has attracted much interest over the past decade. Nevertheless, bidirectional 180° mechanical switching, i.e., a complete cycle of mechanical writing and then erasing of a ferroelectric nanodomain, has not yet been realized in tip-film architectures. Here, via first-principles-based molecular dynamics simulations, we demonstrate that bidirectional 180° mechanical switching is possible in tip-film architectures when screening condition of ferroelectric films and tip loading force are within an appropriate window. The switching utilizes a delicate competition between the flexoelectric field and an overlooked effective dipolar field. The effective dipolar field dominates at small tip force and trigger switching from a downward single-domain state to an upward poly-domain state, whereas the flexoelectric field dominates at relatively large tip force and enables a back-switching. Bidirectional mechanical switching is achieved by applying tip force pulses with alternatively varying strength. The dipole-dipole interaction dynamics play important roles in mechanical switching.
Long-term interactive corrosion between International Simple Glass and stainless steel
Authors: Mohanty Chandi , Guo Xiaolei , Kaya Huseyin , Gin Stephane , Yang Kun , Zhang Zelong , Kim Seong H. , Lian Jie , Wang Jianwei , Frankel Gerald S. 
Published: June 2022

AbstractThe interactive corrosion between stainless steel 316 (SS) and International Simple Glass (ISG) has been studied for 12 months. The samples were placed in intimate contact to create crevice corrosion conditions on SS in a 0.6 M NaCl solution with and without 142 ppm dissolved silica species enriched in 29Si. Corrosion on SS was observed with large pits located close to the crevice mouth at the end of 1 year in 0.6 M NaCl solution. The SS corrosion was also associated with the dissolution of nearby glass in a highly localized manner. When the leaching solution was saturated with silica species, the corrosion rate of SS was suppressed. However, the presence of SS enhances ISG dissolution in both conditions. The implications of the observed phenomena on the long-term storage of nuclear waste are discussed.
Unraveling the role of tungsten as a minor alloying element in the oxidation NiCr alloys
Authors: Volders Cameron , Angelici Valentina Avincola , Waluyo Iradwikanari , Hunt Adrian , Árnadóttir Líney , Reinke Petra 
Published: June 2022

AbstractNi-based superalloys offer a unique combination of mechanical properties, corrosion resistance and high temperature performance. Near ambient pressure X-ray photoelectron spectroscopy was used to study in operando the initial steps of oxidation for Ni-5Cr, Ni-15Cr, Ni-30Cr and Ni-15Cr-6W at 500 °C, p(O2)=10−6 mbar. The comparison of oxide evolution for these alloys quantifies the outsized impact of W in promoting chromia formation. For the binary alloys an increase in chromia due to Cr-surface enrichment is followed by NiO nucleation and growth thus seeding a dual-layer structure. The addition of W (Ni-15Cr-6W) shifts the reaction pathways towards chromia thus enhancing oxide quality. Density functional theory calculations confirm that W atoms adjacent to Cr create highly favorable oxygen adsorption sites. The addition of W supercharges the reactivity of Cr with oxygen essentially funneling oxygen atoms into Cr sites. The experimental results are discussed in the context of surface composition, chemistry, reactant fluxes, and microstructure.
Measuring Rényi entanglement entropy with high efficiency and precision in quantum Monte Carlo simulations
Authors: Zhao Jiarui , Chen Bin-Bin , Wang Yan-Cheng , Yan Zheng , Cheng Meng , Meng Zi Yang 
Published: June 2022

AbstractWe develop a nonequilibrium increment method in quantum Monte Carlo simulations to obtain the Rényi entanglement entropy of various quantum many-body systems with high efficiency and precision. To demonstrate its power, we show the results on a few important yet difficult (2 + 1)dquantum lattice models, ranging from the Heisenberg quantum antiferromagnet with spontaneous symmetry breaking, the quantum critical point with O(3) conformal field theory (CFT) to the toric code$${{\mathbb{Z}}}_{2}$$Z2topological ordered state and the Kagome$${{\mathbb{Z}}}_{2}$$Z2quantum spin liquid model with frustration and multi-spin interactions. In all these cases, our method either reveals the precise CFT data from the logarithmic correction or extracts the quantum dimension in topological order, from the dominant area law in finite-size scaling, with very large system sizes, controlled errorbars, and minimal computational costs. Our method, therefore, establishes a controlled and practical computation paradigm to obtain the difficult yet important universal properties in highly entangled quantum matter.
The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch
Authors: Asimakidou Evridiki , Job Xavier , Kilteni Konstantina 
Published: June 2022

AbstractThe brain predicts the sensory consequences of our movements and uses these predictions to attenuate the perception of self-generated sensations. Accordingly, self-generated touch feels weaker than an externally generated touch of identical intensity. In schizophrenia, this somatosensory attenuation is substantially reduced, suggesting that patients with positive symptoms fail to accurately predict and process self-generated touch. If an impaired prediction underlies the positive symptoms of schizophrenia, then a similar impairment should exist in healthy nonclinical individuals with high positive schizotypal traits. One hundred healthy participants (53 female), assessed for schizotypal traits, underwent a well-established psychophysics force discrimination task to quantify how they perceived self-generated and externally generated touch. The perceived intensity of tactile stimuli delivered to their left index finger (magnitude) and the ability to discriminate the stimuli (precision) was measured. We observed that higher positive schizotypal traits were associated with reduced somatosensory attenuation and poorer somatosensory precision of self-generated touch, both when treating schizotypy as a continuous or categorical variable. These effects were specific to positive schizotypy and were not observed for the negative or disorganized dimensions of schizotypy. The results suggest that positive schizotypal traits are associated with a reduced ability to predict and process self-generated touch. Given that the positive dimension of schizotypy represents the analogue of positive psychotic symptoms of schizophrenia, deficits in processing self-generated tactile information could indicate increased liability to schizophrenia.
Impact of mandatory vaccination against serogroup C meningococci in targeted and non-targeted populations in France
Authors: Taha Samy , Taha Muhamed-Kheir , Deghmane Ala-Eddine 
Published: June 2022

AbstractSince January 2018, mandatory vaccination against meningococci serogroup C has been implemented in France for children <2 years with a recommended catch-up vaccination until the age of 24 years. We aimed to analyse the impact of mandatory vaccination on populations not targeted by it (2–24 years old). We used the database of the national reference centre for meningococci to collect the number of invasive meningococcal disease (IMD) cases before (2016–2017) and after (2018–2019) the mandatory vaccination. The cultured isolates were sequenced and submitted for genomic comparison. The total number of cases was 1706, including 376 cases of IMD serogroup C. Mandatory vaccination correlated with a significant decrease among the <2 years old and a decreasing trend among the 2–14 years old group but not among 15–25 years of age. This observation may be explained by the vaccine coverage that is still low among adolescents and young adults. Moreover, the genomic analysis revealed the co-circulation of two major genotypes belonging to the clonal complex ST-11 whose distribution differed across the age groups in accord with cyclic variations of genotypes. It is important to increase specific knowledge on meningococcal epidemiology and vaccination to involve them in establishing the vaccination strategy.
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
Authors: Subbiah Jeeva , Oh Judy , Kim Ki-Hye , Shin Chong-Hyun , Park Bo Ryoung , Bhatnagar Noopur , Seong Baik-Lin , Wang Bao-Zhong , Kang Sang-Moo 
Published: June 2022

AbstractWe developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the drawbacks of low efficacy by monomeric domain-based universal vaccines. M2e-H3 stalk protein expressed and purified from Escherichia coli was thermostable, displaying native-like antigenic epitopes recognized by antisera of different HA subtype proteins and influenza A virus infections. Adjuvanted M2e-H3 stalk vaccination induced M2e and stalk-specific IgG antibodies recognizing viral antigens on virus particles and on the infected cell surface, CD4+ and CD8+ T-cell responses, and antibody-dependent cytotoxic cell surrogate activity in mice. M2e-H3 stalk was found to confer protection against heterologous and heterosubtypic cross-group subtype viruses (H1N1, H5N1, H9N2, H3N2, H7N9) at similar levels in adult and aged mice. These results provide evidence that M2e-H3 stalk chimeric proteins can be developed as a universal influenza A virus vaccine candidate for young and aged populations.
Finger Movement Recognition via High-Density Electromyography of Intrinsic and Extrinsic Hand Muscles
Authors: Hu Xuhui , Song Aiguo , Wang Jianzhi , Zeng Hong , Wei Wentao 
Published: June 2022

AbstractSurface electromyography (sEMG) is commonly used to observe the motor neuronal activity within muscle fibers. However, decoding dexterous body movements from sEMG signals is still quite challenging. In this paper, we present a high-density sEMG (HD-sEMG) signal database that comprises simultaneously recorded sEMG signals of intrinsic and extrinsic hand muscles. Specifically, twenty able-bodied participants performed 12 finger movements under two paces and three arm postures. HD-sEMG signals were recorded with a 64-channel high-density grid placed on the back of hand and an 8-channel armband around the forearm. Also, a data-glove was used to record the finger joint angles. Synchronisation and reproducibility of the data collection from the HD-sEMG and glove sensors were ensured. The collected data samples were further employed for automated recognition of dexterous finger movements. The introduced dataset offers a new perspective to study the synergy between the intrinsic and extrinsic hand muscles during dynamic finger movements. As this dataset was collected from multiple participants, it also provides a resource for exploring generalized models for finger movement decoding.