bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why is Babesia not killed by artemisinin like Plasmodium?
Authors: Si Wenwen , Fang Chuantao , Liu Chuang , Yin Meng , Xu Wenyue , Li Yanna , Yan Xiaoli , Shen Yujuan , Cao Jianping , Sun Jun 
Published: August 2022

AbstractBabesia spp. are intraerythrocytic apicomplexan organisms digesting hemoglobin similar to intraerythrocytic Plasmodium spp. However, unlike Plasmodium spp., Babesia spp. are not sensitive to artemisinin, The difference between Babesia genomes and Plasmodium genomes revealed that smaller Babesia genomes lack numerous genes, especially haem synthesis-related genes. Single-cell sequencing analysis showed that different groups of B. microti with expressed pentose phosphate pathway (PPP)-related, DNA replication-related, antioxidation-related, glycolysis-related, and glutathione-related genes were not as sensitive to artemether as P. yoelii 17XNL. Especially, PPP-related, DNA replication-related, and glutathione-related genes were inactively expressed compared with P. yoelii 17XNL. Adding iron supply in vivo can promote the reproduction of B. microti. These results suggest that Babesia spp. lack a similar mechanism to that in malaria parasites, by which haem or iron in hemoglobin is utilized, but it likely leads to their insensitivity to artemisinin in turn.Author summaryBabesia and Plasmodium are similar in many ways, from morphology to life history. In particular, both ingest and break down hemoglobin. However, compared with Plasmodium, Babesia cannot form hemozoin with less pathogenicity and insensitivity to artemisinin. Recent studies suggest that artemisinin can kill malaria parasites through free-radical and iron-capture effects, indicating that iron and haem play a key role in the sensitivity of malaria parasites to artemisinin. The Babesia genome is smaller and does not contain haem synthesis-related genes, indicating low requirements and utilization of haem and iron (HI). Moreover, we found that the expression of PPP-related and DNA replication-related genes is not active, distinctly different from malaria parasites. However, adding iron supply in vivo can increase the infection rate of B. microti. Therefore, we hypothesized that Babesia lacks mechanisms for the efficient utilization of HI, resulting in low requirements for HI, and therefore insensitivity to artemisinin.
Does the market reward meeting or beating analyst earnings forecasts? Empirical evidence from China
Authors: Luo Guqiang , Wang Kun Tracy , Wu Yue 
Published: August 2022

PurposeUsing a sample of 9,898 firm-year observations from 1,821 unique Chinese listed firms over the period from 2004 to 2019, this study aims to investigate whether the market rewards meeting or beating analyst earnings expectations (MBE).Design/methodology/approachThe authors use an event study methodology to capture market reactions to MBE.FindingsThe authors document a stock return premium for beating analyst forecasts by a wide margin. However, there is no stock return premium for firms that meet or just beat analyst forecasts, suggesting that the market is skeptical of earnings management by these firms. This market underreaction is more pronounced for firms with weak external monitoring. Further analysis shows that meeting or just beating analyst forecasts is indicative of superior future financial performance. The authors do not find firms using earnings management to meet or just beat analyst forecasts.Research limitations/implicationsThe authors provide evidence of market underreaction to meeting or just beating analyst forecasts, with the market's over-skepticism of earnings management being a plausible mechanism for this phenomenon.Practical implicationsThe findings of this study are informative to researchers, market participants and regulators concerned about the impact of analysts and earnings management and interested in detecting and constraining managers' earnings management.Originality/valueThe authors provide new insights into how the market reacts to MBE by showing that the market appears to focus on using meeting or just beating analyst forecasts as an indicator of earnings management, while it does not detect managed MBE. Meeting or just beating analyst forecasts is commonly used as a proxy for earnings management in the literature. However, the findings suggest that it is a noisy proxy for earnings management.
Enhancing the effects of creativity training for business school students through art-based methods and blended learning
Authors: Kuo Tsung-Hsien , Tien Han-Kuang 
Published: August 2022

PurposeThe content of training (art-based method) and instructional strategies (blended learning) can improve business school students' creativity and attempts to determine how training can be maintained using longitudinal tracking. The study aims to answer (1) whether the incorporation of art-based methods enhances the creativity of students compared to traditional face-to-face (F2F) teaching, and (2) whether such creative training and blended teaching methods have a higher transfer of training.Design/methodology/approachThis study adopted a two-stage design (1) it adopted a 2 × 2 (with or without art-based methods * blended teaching or F2F teaching) between-subject design of experiments with 221 participants and (2) a one-year follow-up study was conducted (participants who were employed for 6 months to one year after graduation) with 187 participants and their directors.FindingsThe results showed that the inclusion of art-based methods in the creative training of students strengthens creative ability of the students; there were no significant differences between blended and traditional learning. The authors examined the effect of transferring creative training through a questionnaire analysis of participants and employers of the participants. Self-regulated and self-directed learning positively influence motivation to transfer, which positively influences creative performance.Originality/valueThe higher the level of self-regulated and self-directed learning of students, the more effective the transfer of creative training is over time.
The impact of task-oriented leadership to subordinates' knowledge creation behavior – based on organismic integration theory
Authors: Ma Fangfei , Zhao Hongchao , Wu Chunbo 
Published: August 2022

PurposeCompetitiveness of pharmaceutical companies hugely depends on new knowledge because of ever-changing technologies and forefront of knowledge. Leadership styles appear to influence knowledge management behavior, but there has been little empirical research on employees' knowledge creation behavior as an outcome of leadership. The study examines how task-oriented leadership affects subordinates' knowledge creation behavior. Based on organismic integration theory (OIT), the study proposes that perception of competitive climate and achievement motivation can conduct as mediators.Design/methodology/approachData were collected from 877 full-time working employees in five pharmaceutical companies in China. Participants answered demographic questions and completed the task-oriented leadership, perception of competitive climate, achievement motivation, as well as knowledge creation behavior scale. Structural equation modeling was used to test the hypothesized relationships.FindingsThe results review that task-oriented leadership will significantly promote subordinates' knowledge creation behavior. Perception of competitive climate and achievement motivation play mediator roles between task-oriented leadership and subordinates knowledge creation behavior. Perception of competitive climate and achievement motivation have a serial mediating effect between task-oriented leadership and subordinates knowledge creation behavior.Practical implicationsBy adopting a task-oriented leadership style through training and development, leaders may stimulate employees more knowledge creation behaviors by transmitting the organization's vision, clarifying their work tasks and setting relatively high-performance standards. Then, organizations should establish a competition mechanism to promote competition among employees, while also preventing malicious competition. Finally, organizations should arouse employees' achievement motivation to stimulate their internal pursuit of success and needs.Originality/valueBecause of the improvement of information technology and the acceleration of knowledge dissemination, the need for new knowledge is becoming more and more urgent in organizations. Knowledge, as a resource that needs to be managed in an organizational environment, has regained researchers' attention. However, a flourishing number of studies explain the organizational knowledge management from the macro level, there is a need to explore how leaders influence their subordinates to create knowledge. From the perspective of extrinsic motivation internalization, this study’s findings contribute to the literature on task-oriented leadership and knowledge creation behavior and expand our understanding of why task-oriented leadership promotes subordinates' knowledge creation behavior.
Performance analysis of textured journal bearing operating with and without nanoparticles in the lubricant
Authors: Byotra Deepak , Sharma Sanjay 
Published: August 2022

Purpose
This study aims to investigate the performance improvement of journal bearing by applying the arc-shaped textures on various regions of bearing expressly full, second half and pressure increasing regions operating with and without nanoparticles in the lubricant.

Design/methodology/approach
The Reynolds equation is solved numerically by using the finite element method to obtain static performance parameters such as load-carrying capacity (LCC) and coefficient of friction (COF), which are then compared with untextured bearing at eccentricity ratios of 0.2 to 0.8. Aluminum oxide (Al2O3) and copper oxide (CuO) nanoparticles additives are used, and viscosity variation due to the addition of additives in the base lubricant is computed for considering the range of temperatures 50 to 90°C at a weight fraction of 0.1 to 0.5% by using an experimentally validated regression model.

Findings
The results indicate that the maximum LCC and the lower COF are found in the pressure-increasing region. A maximum increase of 34.42% is observed in the pressure-increasing region without nanoparticles, and furthermore, with the addition of Al2O3 and CuO nanoparticles in lubricants in the same region, the LCC increased to 21 and 24%, respectively.

Originality/value
Designers should use optimal parameters from the present work to achieve high bearing performance.
Comparative research on structure function recognition based on deep learning
Authors: Liu Zhongbao , Zhao Wenjuan 
Published: August 2022

PurposeThe research on structure function recognition mainly concentrates on identifying a specific part of academic literature and its applicability in the multidiscipline perspective. A specific part of academic literature, such as sentences, paragraphs and chapter contents are also called a level of academic literature in this paper. There are a few comparative research works on the relationship between models, disciplines and levels in the process of structure function recognition. In view of this, comparative research on structure function recognition based on deep learning has been conducted in this paper.Design/methodology/approachAn experimental corpus, including the academic literature of traditional Chinese medicine, library and information science, computer science, environmental science and phytology, was constructed. Meanwhile, deep learning models such as convolutional neural networks (CNN), long and short-term memory (LSTM) and bidirectional encoder representation from transformers (BERT) were used. The comparative experiments of structure function recognition were conducted with the help of the deep learning models from the multilevel perspective.FindingsThe experimental results showed that (1) the BERT model performed best, with F1 values of 78.02, 89.41 and 94.88%, respectively at the level of sentence, paragraph and chapter content. (2) The deep learning models performed better on the academic literature of traditional Chinese medicine than on other disciplines in most cases, e.g. F1 values of CNN, LSTM and BERT, respectively arrived at 71.14, 69.96 and 78.02% at the level of sentence. (3) The deep learning models performed better at the level of chapter content than other levels, the maximum F1 values of CNN, LSTM and BERT at 91.92, 74.90 and 94.88%, respectively. Furthermore, the confusion matrix of recognition results on the academic literature was introduced to find out the reason for misrecognition.Originality/valueThis paper may inspire other research on structure function recognition, and provide a valuable reference for the analysis of influencing factors.
The link between supervisor support, servicing efficacy and job satisfaction among frontline hotel employees: an investigation in Turkey
Authors: Öksüz Merve , Tosyalı Hikmet , Tosyali Furkan 
Published: August 2022

PurposeThis paper aims to examine the association between supervisor support, servicing efficacy and job satisfaction among frontline hotel employees in Turkey. Specifically, the mediating role of servicing efficacy was examined in the link between supervisor support and job satisfaction.Design/methodology/approachData were collected from 421 frontline employees in 4- and 5-star hotels located in the South and South West of Turkey. The authors proposed a conceptual model in which servicing efficacy mediates the link between supervisor support and job satisfaction after controlling for demographic information. Data were analyzed through the structural equation modeling (SEM) framework.FindingsResults showed that supervisor support positively predicted servicing efficacy and job satisfaction reports of the employees. Those reporting higher servicing efficacy were more likely to report increased job satisfaction. In addition, servicing efficacy partially mediated the link between supervisor support and job satisfaction.Originality/valueThe current study provides new evidence on the link between supervisor support, efficacy beliefs and job satisfaction in the hotel industry. This is the first study investigating the mediating role of servicing efficacy in the association between supervisor support and job satisfaction. Moreover, most previous studies separately focusing on supervisor support, efficacy beliefs and job satisfaction in the hospitality industry were conducted in developed, Western countries. In contrast, research examining work-related constructs and outcomes in Turkey’s hospitality industry has been limited. Thus, both replicated and original findings would contribute to the generalizability of cumulative knowledge in tourism and hospitality.
A lipopolysaccharide‐dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance
Authors: Warring Suzanne L. , Malone Lucia M. , Jayaraman Jay , Easingwood Richard A. , Rigano Luciano A. , Frampton Rebekah A. , Visnovsky Sandra B. , Addison Shea M. , Hernandez Loreto , Pitman Andrew R. , Lopez Acedo Elena , Kleffmann Torsten , Templeton Matthew D. , Bostina Mihnea , Fineran Peter C. 
Published: August 2022

AbstractBacterial pathogens are major causes of crop diseases, leading to significant production losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae pv. actinidiae (Psa), has posed a global challenge to kiwifruit production. Treatment with copper and antibiotics, whilst initially effective, is leading to the rise of bacterial resistance, requiring new biocontrol approaches. Previously, we isolated a group of closely related Psa phages with biocontrol potential, which represent environmentally sustainable antimicrobials. However, their deployment as antimicrobials requires further insight into their properties and infection strategy. Here, we provide an in‐depth examination of the genome of ΦPsa374‐like phages and show that they use lipopolysaccharides (LPS) as their main receptor. Through proteomics and cryo‐electron microscopy of ΦPsa374, we revealed the structural proteome and that this phage possess a T = 9 capsid triangulation, unusual for myoviruses. Furthermore, we show that ΦPsa374 phage resistance arises in planta through mutations in a glycosyltransferase involved in LPS synthesis. Lastly, through in vitro evolution experiments we showed that phage resistance is overcome by mutations in a tail fibre and structural protein of unknown function in ΦPsa374. This study provides new insight into the properties of ΦPsa374‐like phages that informs their use as antimicrobials against Psa.
A process approach to quality management doublesNEONsensor data quality
Authors: Sturtevant Cove , DeRego Elizabeth , Metzger Stefan , Ayres Edward , Allen Dan , Burlingame Teresa , Catolico Nora , Cawley Kaelin , Csavina Janae , Durden David , Florian Christopher , Frost Shalane , Gaddie Ross , Knapp Elizabeth , Laney Christine , Lee Robert , Lenz Dawn , Litt Guy , Luo Hongyan , Roberti Joshua , Slemmons Caleb , Styers Kevin , Tran Chau , Vance Tanya , SanClements Michael 
Published: August 2022

AbstractA quality management system is critical for ensuring that the data and services provided by an organization meet the needs of its mission. With a mission to collect long‐term open‐access ecological data to better understand how US ecosystems are changing, the National Ecological Observatory Network (NEON) is a highly standardized measurement network distributed across the United States and Puerto Rico collecting data on the biosphere and its interfaces with the pedosphere, hydrosphere and atmosphere.In order to achieve high‐quality, comparable data across the network, a quality management system was developed by applying the seven ISO 9001:2015 principles of quality management:customer focus,leadership, engagement of people, process approach, improvement, evidence‐based decision makingandrelationship management. The resultant system is integrated throughout NEON's organizational structure with an approach that connects people and operational processes throughout the data life cycle (process approach).We describe the system with respect to sensor data (automated measurements), demonstrating its effectiveness through examples, lessons learned and a continuous history of improvement towards quality goals, including a doubling of data quality in NEON's meteorological and soil datasets since 2015 and substantial gains in other sensor datasets.Owing to a focus on quality management principles and particularly the interconnectedness of human and information systems, NEON's quality management system can serve as a model for networks with a variety of organizational structures and sizes.
Global emergency medicine: A scoping review of the literature from 2021
Authors: Kivlehan Sean M. , Hexom Braden J. , Bonney Joseph , Collier Amanda , Nicholson Benjamin D. , Quao Nana Serwaa A. , Rybarczyk Megan M. , Selvam Anand , Rees Chris A. , Roy Charlotte M. , Bhaskar Nidhi , Becker Torben K. ,   Global Emergency Medicine Literature Review (GEMLR) Group
Published: August 2022

AbstractObjectiveThe objective was to identify the most important and impactful peer‐reviewed global emergency medicine (GEM) articles published in 2021. The top articles are summarized in brief narratives and accompanied by a comprehensive list of all identified articles that address the topic during the year to serve as a reference for clinicians, researchers, and policy makers.MethodsA systematic PubMed search was carried out to identify all GEM articles published in 2021. Title and abstract screening was performed by trained reviewers and editors to identify articles in one of three categories based on predefined criteria: disaster and humanitarian response (DHR), emergency care in resource‐limited settings (ECRLS), and emergency medicine development (EMD). Included articles were each scored by two reviewers using established rubrics for original (OR) and review (RE) articles. The top 5% of articles overall and the top 5% of articles from each category (DHR, ECRLS, EMD, OR, and RE) were included for narrative summary.ResultsThe 2021 search identified 44,839 articles, of which 444 articles screened in for scoring, 25% and 22% increases from 2020, respectively. After removal of duplicates, 23 articles were included for narrative summary. ECRLS constituted the largest category (n = 16, 70%), followed by EMD (n = 4, 17%) and DHR (n = 3, 13%). The majority of top articles were OR (n = 14, 61%) compared to RE (n = 9, 39%).ConclusionsThe GEM peer‐reviewed literature continued to grow at a fast rate in 2021, reflecting the continued expansion and maturation of this subspecialty of emergency medicine. Few high‐quality articles focused on DHR and EMD, suggesting a need for further efforts in those fields. Future efforts should focus on improving the diversity of GEM research and equitable representation.
Noninferior oncological outcomes in adults aged 80 years or older compared with younger patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma
Authors: Yamada Yasufumi , Ikeda Masaomi , Hirayama Takahiro , Murakami Yasukiyo , Koguchi Dai , Matsuda Daisuke , Okuno Norihiko , Taoka Yoshinori , Utsunomiya Takuji , Irie Akira , Matsumoto Kazumasa , Iwamura Masatsugu 
Published: August 2022

AbstractAimRadical nephroureterectomy (RNU) is the gold standard treatment for upper tract urothelial carcinoma (UTUC), but the usefulness of this surgery for older patients is rarely discussed. The prognosis following RNU for patients ≥80 years old remains controversial. We retrospectively investigated the prognosis of UTUC in patients ≥80 years old who underwent RNU.MethodsBetween January 1990 and December 2015, 451 patients with UTUC underwent RNU at six hospitals affiliated with Kitasato University (Kanagawa, Japan), eight patients who underwent neoadjuvant chemotherapy and two patients with metastases before surgery were excluded. Patients were divided into three groups according to their age at the time of RNU: ≤64 years (n = 135), 65–79 years (n = 254), and ≥80 years (n = 52). Recurrence‐free survival (RFS), cancer‐specific survival (CSS), and overall survival (OS) curves were estimated using Kaplan–Meier analysis for all patients and each pT stage. Independent prognostic factors for survival were examined via multivariate analysis.ResultsRFS and CSS did not significantly differ between the three groups, but OS was significantly poorer in patients ≥80 years old. Stratification by pT stage (≤pT1, ≥pT2, and ≥pT3) yielded the same results. In the multivariate analysis for OS, an age of ≥80 years was a significant independent risk factor (hazard ratio: 3.01, p = .01), but RFS and CSS did not significantly differ.ConclusionOncological outcomes showed the same anticancer effects in patients ≥80 years old who underwent RNU for UTUC compared with those of younger patients. Our study suggests that surgical treatment is a beneficial option for older patients who can tolerate radical surgery.