bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk of symptomatic venous thromboembolism after total knee arthroplasty for valgus deformity is comparable to that for varus deformity, but revision is 2.5 times higher
Authors: Xu Kuishuai , Zhang Liang , Song Wenlian , Ren Zhongkai , Wang Tianrui , Zhang Yingze , Zhao Xia , Yu Tengbo 
Published: September 2022

Abstract
Purpose
To study the difference of perioperative symptomatic venous thromboembolism (VTE) and prosthesis revision rate in patients with valgus knee osteoarthritis by comparing with patients undergoing total knee arthroplasty(TKA) for varus deformity and analyze the reasons for revision. At the same time, the distribution and radiographic features of lower extremity deep venous thrombosis were recorded.
Methods
8917 patients who underwent primary unilateral TKA in our hospital from 2011 to 2020 were retrospectively analyzed and all patients assigned to two groups: valgus group (n = 412) and varus group (n = 8505). Main indicators included the incidence of symptomatic VTE and prosthesis revision. Secondary outcomes included general information on operative time, Kellgren and Lawrence score, total hospital stay and total costs.
Results
In our hospital, the proportion of valgus knees in TKA patients was 4.62% (412/8917), the incidence of VTE events was 6.17‰ (55/8917), and most deep venous thrombosis occurred in the distal lower extremities (51/55), mainly in the intermuscular veins (43/53). The incidence of VTE was 6.23‰(53/8505) and 4.85‰(2/412) in the varus and valgus groups, and the results were not statistically different (P = 0.727). There was no significant difference in echogenicity, number of occluded vessels and thrombus length between the valgus group (P = 0.942, P = 0.653, P = 0.684). Total prosthesis revision after TKA was 5.16‰(46/8917), and infection was the main reason for revision (26/46). Patients with valgus deformity had 12.14‰(5/412) prosthesis revision, the incidence of varus deformity was 4.82‰ (41/8505), and the revision risk of valgus group was 2.5 times higher than varus group, and the results were statistically different (P = 0.043). The operation time and hospital stay in the valgus group were longer than those in the varus group, and the results were statistically different (P = 0.018, P < 0.001).
Conclusions
The proportion of valgus knees in TKA patients in our hospital was 4.62%, which was lower than that in previous reports. Compared with the varus group, no difference was found in the incidence of symptomatic VTE, thrombus location, echogenicity, number of occluded vessels, and thrombus length after TKA in the valgus group, but the prosthesis revision rate was 2.5 times higher in the valgus group than in the varus group,higher revision rates may be associated with longer operative times.
Fragility Curve Analysis for G+6 Buildings With an Outer Pheriphery Shear Wall
Authors: M Saravanakumar R , S Samson 
Published: September 2022

Abstract

Although it is impossible to predict the time or location of an earthquake, it is possible to predict the likelihood of a failure after it hits. Six models with different placements of the shear walls are used in this study to predict the probability of failure through fragility curve analysis. For the fragility curve analysis, each model with 40 earthquakes goes through a nonlinear time history analysis. When developing fragility curves, uncertainty is also taken into account. Uncertainties are commonly associated with construction quality, modeling, and materials. After 280 nonlinear time history analyses, the maximum response for each model is determined, and a fragility curve between PGA and probability of exceedance is performed. The SW6 model performs well in the face of seismic action, with damage levels such as immediate occupancy, limit state, and collapse prevention falling within acceptable limits. For a PGA of 0.5, all of these probabilities of exceedance are noted.
Analytical review of Recurring-window based time-varying portfolio crash risks
Authors: Malhotra Rohit 
Published: September 2022

Abstract
The current empirical work used the robust portfolio mechanism using time-varying (aka conditional) skewness and kurtosis on an arbitrary nearly 50-days recurring window. The comparison of the Top GDP nations (mainly 6 of them according to December 2019 data) was conducted applying the recurring windows based time-varying higher moments on both at individual stock indexes as well as towards covid data. The underline objective was to ensure that the time varying patterns at covid-related “crashes'' vis-a-vis market crashes are managed through an appropriate time-varying portfolio moments specifically for recurring windows since covid pandemic was a kind of “rolling crisis” and its impact was found to be heterogeneous in terms of its intensity and effect on the global financial markets. In the end, the principal component analysis was used to further investigate the orthogonality in reference to the rolling window time varying moments across the six economies in consideration.
JEL C180, G1, G 150
Sex and the estrous-cycle phase influence the expression of G protein-coupled estrogen receptor 1 (GPER) in schizophrenia: translational evidence for a new target.
Authors: Silva Francisco Eliclécio Rodrigues da , Cordeiro Rafaela Carneiro , Lima Camila Nayane de Carvalho , Cardozo Pablo Leal , Vasconcelos Germana Silva , Monte Aline Santos , Sanders Lia Lira Olivier , Vasconcelos Silvânia Maria Mendes , de Lucena David Freitas , Cruz Breno Fiuza , Nicolato Rodrigo , Seeman Mary V. , Ribeiro Fabíola Mara , Macedo Danielle 
Published: September 2022

Abstract
Schizophrenia is a mental disorder with sex bias in disease onset and symptom severity. Recently, it was observed that females present more severe symptoms in the perimenstrual phase of the menstrual cycle. The administration of estrogen also alleviates schizophrenia symptoms. Despite this, little is known about symptom fluctuation over the menstrual cycle and the underlying mechanisms. To address this issue, we worked with the two-hit schizophrenia animal model induced by neonatal exposure to a virus-like particle, Poly I:C, in association with peripubertal unpredictable stress exposure. Prepulse inhibition of the startle reflex (PPI) in male and female mice was considered analogous to human schizophrenia-like behavior. Female mice were studied in the proestrus (high-estrogen estrous cycle phase) and diestrus (low-estrogen phase). Additionally, we evaluated the hippocampal mRNA expression of estrogen synthesis proteins, TSPO and aromatase, and estrogen receptors ERα, ERβ, and GPER. We also collected Peripheral Blood Mononuclear Cells (PBMCs) from male and female patients with schizophrenia and converted them to induced microglia-like cells (iMGs) to evaluate the expression of GPER. We observed raised hippocampal expression of GPER in two-hit female mice at the proestrus phase without PPI deficits and higher levels of proteins related to estrogen synthesis, TSPO, and aromatase. In contrast, two-hit adult males with PPI deficits presented lower hippocampal mRNA expression of TSPO, aromatase, and GPER. iMGs from male and female patients with schizophrenia showed lower mRNA expression of GPER than controls. Therefore, our results suggest that GPER alterations constitute an underlying mechanism for sex influence in schizophrenia.
Realistic environmental exposure to secondary PET microplastics induces biochemical responses in freshwater amphipod Hyalella azteca
Authors: Queiroz Lucas , Rani-Borges Bárbara , Prado Caio , Moraes Beatriz , Ando Rômulo , Paiva Teresa , Pompêo Marcelo 
Published: September 2022

Abstract
Aquatic environments are especially susceptible to microplastic contamination. This is mainly because these water bodies serve as a transport route for these particles from the terrestrial environment until they reach the oceans. Also, there is a lack of available data about the effects of this pollutant on freshwaters making difficult the conservation of these environments. Benthic species, such as the freshwater amphipod Hyalella azteca, have been superficially studied so far. Considering its essential role in the trophic chain as a primary consumer, it becomes a topic of great relevance to investigate the responses triggered by microplastics in these organisms. In this study, we analyzed whether polyethylene terephthalate microplastics could lead to reduced survival of H. azteca or changes in biochemical markers (SOD, CAT, MDA, and GST) at environmentally relevant concentrations (60 and 600 particles per treatment) after 7 days of exposure. The results showed that there was no significant mortality at any of the concentrations tested. The enzyme CAT showed no variation compared to the control group at any of the concentrations. SOD, MDA, and GST were statistically different (p < 0.05). Our study demonstrates that although there was no significant mortality after exposure at an environmentally realistic concentration, the macrobenthic invertebrate community may be under threat in environments where there is microplastic pollution since biochemical changes may be detected at such concentrations as low as 60 particles.
Exponential stabilization of stochastic complex networks with Markovian switching topologies via intermittent discrete-time state observations control
Authors: Zheng Naiqin , Han Naqin , Gunasekaran Nallappan 
Published: September 2022

Abstract
This paper is concerned with the exponential stability of the stochastic complex networks with Markovian switching topologies. It is worth emphasizing that the topological structure of the stochastic control system is Markovian switching and it is neither required that all switching subnetworks contain a spanning tree nor that they are strongly connected. Moreover, a new type of control, aperiodically intermittent discrete-time state observations control, is proposed. By using the Lyapunov method and graph theory, a theorem with the sufficient conditions for exponential convergence of the state to zero and two corollaries are established. In addition, our theoretical results are used to discuss exponential stability of stochastic coupled oscillators and a communication network model, respectively. Finally, two numerical examples are given to verify the effectiveness of the results.
Self-Oblivion Questionnaire Development and its Reliability and Validity
Authors: Mao Huapei , Zhang Ke , Lin Yingying , Wang Danni , Liao Chuanjing , Sun Daokai 
Published: September 2022

Abstract
Aim：Develop Self Oblivion trait questionnaire, explore its structure and examine its reliability and validity.
Method：Thematic keywords were extracted to form a preliminary questionnaire and an actual questionnaire through literature reviews of Taoism’s Self Oblivion literature and interview with relevant parties. Preliminary test was administered to 303 tertiary students and working adults, where questionnaire items were analyzed for their quality and structure of the questionnaire was examined. The actual test was administered on other 361 tertiary students and working adults, of which went through confirmatory factor analysis and criterion analysis.
Results：Exploratory factor analysis showed that Oblivion of Self questionnaire is made up of 3 factors (15 items in total). Confirmatory factor analysis results support the trifactor structure, where fit indices were reasonable. Self Oblivion trait scores are negatively related to anxiety trait (-0.374), but positively related to peace of mind and mindful attention awareness (0.348 and 0.247 respectively). The overall questionnaire has an internal consistency coefficient of 0.849, and the three factors have an internal consistency coefficient of 0.828-0,904. Retest reliability of the overall questionnaire is 0.738, and the retest reliability of the three factors range between 0.694 and 0.785.
Conclusion：The Self-Oblivion questionnaire developed in this study possess good reliability and validity, which can be used as an assessment instrument for further study and in practice.
Brassica seed meal fumigation restores beneficial bacterial communities by enriching taxa with high resistance and resilience
Authors: Peng Junwei , Shen Minchong , Chen Ruihuan , Liu Hong , Sun Yang , Liu Qin , Dong Yuanhua , Li Jiangang 
Published: September 2022

Abstract

Purpose
Brassica seed meals (BSMs) are widely used as biofumigants to control various soil-borne plant diseases. However, the mechanism of bacterial community reconstruction following fumigation with BSMs remains poorly understood.
Methods
In the present study, to decipher the mechanism of bacterial community reconstruction in fumigated soil and to understand the effect of bacterial communities in fumigated soil on rhizosphere recruitment and subsequent disease control, we investigated the bulk soil and rhizosphere bacterial communities using field experiments in soils treated with various fumigants (Brassica campestris seed meal, Brassica juncea seed meal, and the chemical fumigant dazomet) in two greenhouses subsequently used to grow tomato and cantaloupe, respectively.
Results
This study revealed that bulk soil bacterial community composition changed significantly after fumigation extinction and recovery. Firmicutes and Proteobacteria, showing high resistance and resilience in the extinction and recovery processes, respectively, represented the key microorganisms for community reconstruction and rhizosphere recruitment. Moreover, nutrients supplied by BSMs, especially available phosphorus (AP), in fumigated soils determined the post-restoration changes in bacterial community composition. Additionally, BSMs showed greater potential than chemical fumigant dazomet in rebuilding beneficial bacterial communities and controlling potential soil pathogens by enriching gram-positive bacteria (Firmicutes and Actinobacteria) and genera Bacillus and Streptomyces.
Conclusion
These results provide a clear understanding of the response of soil-inhabiting microbes to fumigation and the reconstruction of soil beneficial bacterial communities after BSM fumigation. Thus, this study improves the understanding of the effects of biofumigants on soil-borne plant disease control in agriculture.
Whole-Transcriptome Sequencing Analysis Reveal Mechanisms of Yiqi Huoxue Yangyin (YHY) Decoction in Ameliorating D-gal-induced Cardiac Aging
Authors: Wang Xue , Xiu ChengKui , Yang Jing , Liu YiQing , Zhang Jiaqi , Lei Yan 
Published: September 2022

Abstract
Background
Aging is a major factor for cardiovascular disease, and cardiac aging is closely related to the incidence of cardiovascular disease. Clarifying the mechanism of cardiac aging and finding reliable intervention is critical for preventing cardiovascular diseases and achieving healthy longevity. Traditional Chinese medicine Yiqi Huoxue Yangyin (YHY) decoction has unique advantages in the treatment of cardiovascular disease and aging. However, the associated molecular mechanisms remain unknown.
Purpose
The present study aimed to verify the efficacy of YHY decoction against cardiac aging in D-gal-induced mouse model, and explore the potential mechanisms of YHY decoction treatment through whole-transcriptome sequencing technique, providing novel insights into the molecular basis of YHY decoction in treating cardiac aging.
Methods
The component of YHY decoction was identified by High Performance Liquid Chromatography (HPLC). D-gal-induced aging mouse model was established for this study. HE and Masson staining were applied to determined pathological changes of heart; telomere length, telomerase activity, AGEs and p53 were used to evaluated the degree of heart aging. Transcriptome sequencing, GO, KEGG, GSEA and ceRNA network were applied to analyzing the potential mechanisms of YHY decoction treatment of cardiac aging.
Results
In this study, we found that YHY decoction not only improved the pathological structure of aging heart, but also regulated the expression of aging-related markers, telomere length, telomerase activity, AGEs and p53, in the myocardial tissue, suggesting that it has a specific effect in delaying cardiac aging. Whole-transcriptome sequencing showed that the total of 433 mRNAs, 284 lncRNAs, 62 miRNAs, and 39 circRNAs were significantly differentially expressed after YHY decoction treatment. According to the analysis results of KEGG and GSEA, the differentially expressed mRNAs were found significantly involved in immune system, cytokine-cytokine receptor interaction and cell adhesion molecules. The ceRNA network showed that miR-770, miR-324, and miR-365 are localized in the center, mainly affecting the immune system, PI3K-Akt signaling pathway, and MAPK signaling pathway.
Conclusion
In conclusion, our results evaluated the ceRNA network of YHY decoction in treating cardiac aging for the first time, which could provide a better understanding of the potential mechanisms of YHY decoction treatment of cardiac aging.
A High-Order Hybrid Numerical Scheme for Hypersonic Flow Over A Blunt Body
Authors: Chen Xingxing , Fang Jian , Moulinec Charles , Emerson David 
Published: September 2022

Abstract
A hybrid scheme is developed for direct numerical simulations of hypersonicflows over a blunt body. The scheme switches to the first-order AUSMPW+ scheme near the bow shock to provide sufficient dissipationto handle the carbuncle phenomenon. In the smooth part of the computationaldomain, a sixth-order central scheme with an eighth-orderlow-pass filter is adopted to provide high spatial accuracy to resolve turbulence.The hybrid scheme is shown to be able to obtain smooth andaccurate predictions of laminar hypersonic flows over a blunt body. Usingthe hybrid scheme, a direct numerical simulation of a Mach 6 hypersonicflow over a circular cylinder is conducted. The result shows the turbulentstructures in the near-wall region are well resolved by the hybrid scheme,and the bow shock is also captured without introducing any numericaloscillations. With the boundary layer transition on the cylinder’s surface,the simulation indicates that the heat flux peak shifts from the stagnationpoint to the transitional zone and its peak value is increased by 50%.
Accurate prediction by AlphaFold2 for ligand binding in a reductive dehalogenase: Implications for PFAS (per- and polyfluoroalkyl substance) biodegradation
Authors: Guo Hao-Bo , Varaljay Vanessa , Kedziora Gary , Taylor Kimberly , Farajollahi Sanaz , Lombardo Nina , Harper Eric , Hung Chia , Gross Marie , Perminov Alexander , Dennis Patrick , Kelley-Loughnane Nancy , Berry Rajiv 
Published: September 2022

Abstract
Despite the success of AlphaFold2 (AF2), it is unclear how AF2 models accommodate for ligand binding. Here, we start with a protein sequence from Acidimicrobiaceae TMED77 (T7RdhA) with potential for catalyzing the degradation of per- and polyfluoroalkyl substances (PFASs). AF2 models and experiments identified T7RdhA as a corrinoid iron-sulfur protein (CoFeSP) which uses a norpseudo-cobalamin (BVQ) cofactor and two [4Fe4S] iron-sulfur clusters (SF4) for catalysis. Docking and molecular dynamics simulations suggest that T7RdhA uses perfluorooctanoic acetate (PFOA) as a substrate, supporting the reported defluorination activity of its homolog, A6RdhA. We showed that AF2 provides processual (dynamic) predictions for the binding pockets of ligands (cofactors and/or substrates). Because the pLDDT scores provided by AF2 reflect the protein native states in complex with ligands as the evolutionary constraints, the Evoformer network of AF2 predicts protein structures and residue flexibility in complex with the ligands, i.e., in their native states.
Assessment of early wound healing, pain experience, life quality and related influenced factors during periodontal surgery: a cross-sectional study
Authors: Yuan Hongmei , Liu Qian , Tang Tian , Qin Huan , Zhao Lei , Chen Wen , Guo Shujuan 
Published: September 2022

Abstract
Background
This cross-sectional study was to assess the early wound healing, pain experience, life quality, surgical satisfaction and the related factors during periodontal surgery.
Methods
369 enrolled patients undergoing periodontal surgery completed the questionnaire before (baseline) and after operation immediately (phase I), on the day of suture removal (phase II) and one month later (phase III). The Early Wound Healing Score (EHS), short-form-McGill-Pain-Questionnaire (SF-MPQ) and tooth hypersensitivity visual analogue scales (VAS), oral-health-related-quality-of-life measure (OHQoL-UK) and surgical satisfaction VAS were detected and analysed.
Results
The EHS was 8.41 ± 2.74 and influenced by disease severity and surgical factors. SF-MPQ, pain intensity and OHQoL-UK were significantly increased in phase I and decreased later. The tooth sensitivity decreased significantly after periodontal surgery. Psychological factors positively related with these scores during periodontal surgery. Besides, disease severity and surgical factors were contributed in baseline or in phase I/II/III. Surgical acceptance and re-operation willing were continuously decreased after surgery and related to various and complicated factors.
Conclusions
EHS was good after periodontal surgery and related to disease severity and surgical factors. Pain experience and life quality were deteriorating in phase I but significantly improved later, which were influenced by disease severity, psychological and surgical factors. All these scores related to the surgical satisfaction.
Trial registration:
This cross-sectional study article reported the results without any intervention on human participants and all the experimental procedures involving human in this study were approved by the Ethics Committee of West China college of stomatology, Sichuan University (WCHSIRB-D-2020-284).
Design and modeling of self-organizing manufacturing system in digital twin shop-floor
Authors: Song Jiaye , Zhang Zequn , Tang Dunbing , Zhu Haihua , Wang Liping , Nie Qingwei 
Published: September 2022

Abstract
The increasing personalized product demands bring reformation to the manufacturing paradigm. Traditional manufacturing systems seldom analyze and give feedback on the data collected during production. The bottleneck between the physical and digital worlds of manufacturing systems is the lack of interoperability. In this paper, a digital twin-based self-organizing manufacturing system (DT-SOMS) is presented under the individualization paradigm. On the basis of interconnection between smart workpieces and smart resources via decentralized digital twin models, a decentralized self-organizing network is established to achieve intelligent collaboration between tasks and resources. The mechanism of job-machine optimal assignment and adaptive optimization control is constructed to improve the capabilities of reconfiguration and responsiveness of the DT-SOMS. An implement case is designed to illustrate that the proposed DT-SOMS can realize synchronized online intelligence in the configuration of resources and response to disturbances.
Dynamic survivability in oscillator systems
Authors: Sun Zhongkui , Wang Yuexin 
Published: September 2022

Abstract
Whether the dynamic systems can display normal performance or complete key mission is the hot spot in recent years. In accordance with this, dynamic survivability is defined for the first time and mission-completion-probability is given as an index in this study. Taking the behavior of globally and diffusively coupled oscillator systems with ER and BA network structures as examples, we show the network structures, systems’ parameters and attack strategies exhibit a profound influence on the dynamic survivability. ER and BA systems display better or worse dynamic survivability under different attack strategies respectively. Our outcomes fill the gap in the survivability study and are helpful for enhancing the dynamic survivability of systems.