bluuebunny/crossref_metadata_2025_split huggingface dataset:
SÍNDROME DE MILLER FISHER: UMA PATOLOGIA IMUNOMEDIADA POR ANTICORPOS ANTI-GQ1B
Authors: Araújo João Raphael Calil Lemos , PEIXOTO JULLI MARTINS , RABELO ISADORA DE OLIVEIRA , PEREIRA KELLEN CRISTINE , SILVA JORDANY MOLLINE 
Published: June 2022

Introdução: A síndrome de Miller Fisher (SMF) é uma variante da Síndrome de Guillain Barré (SGB), que cursa com a tríade: ataxia, oftalmoplegia e arreflexia, nessa perspectiva, caracteriza-se como uma síndrome desmielinizante aguda inflamatória e autoimune que acomete o sistema nervoso periférico. Na maioria dos casos, há uma história de infecção prévia (em média 10 dias antes, podendo variar de uma a três semanas) do sistema respiratório ou do sistema nervoso central que precede o aparecimento da sintomatologia sindrômica. Além disso, outros sintomas que levam a suspeita clínica são: gastroenterite, disartria, diplopia, paresia de nervos cranianos, especialmente do nervo facial. Objetivo: Analisar o panorama das publicações acerca da caracterização clínica para o diagnóstico da SMF. Material e métodos: Trata-se de uma revisão de literatura qualitativa realizada por meio de buscas nas bases de dados Google Scholar, Cochrane Library, BVS e PubMed, com seleção de 6 publicações. Resultados: Os fatores que justificam a presença de infecção prévia por agentes como: Campylobacter jejuni, Haemophilus influenzae, Epstein Barr e citomegalovírus e o surgimento da SMF, estão relacionados ao mecanismo de mimetismo molecular entre o gangliosídeo GQ1b nos nervos cranianos e periféricos e os oligossacarídeos presentes na superfície do agente infeccioso em questão, resultando em uma reação cruzada do sistema imune, responsável pela desmielinização dos nervos e aparecimento da sintomatologia da SMF. Dessa forma, o diagnóstico da SMF é baseado na suspeita clínica e em exames complementares, como o estudo para descoberta de anticorpos antigênicos (o anti-GQ1b está diretamente, mas não exclusivamente, relacionado com à SMF). Conclusão: Portanto, a SMF, apesar de rara, possui sintomatologia exuberante que além de afetar a qualidade de vida dos portadores, é um desafio diagnóstico para os médicos, nesse sentido é de fundamental importância que os profissionais estejam aptos a reconhecer a SMF, de forma a tranquilizar os pacientes sobre o caráter autolimitado dos sintomas (em média 3 semanas) e a instituir tratamento que acelere a recuperação como a plasmaférese e a imunoglobulina intravenosa, que inibe a ligação de anticorpos anti-GQ1b a GQ1b, impedindo assim a ligação de anticorpos a GQ1b neural, ativação do complemento e efeitos fisiopatológicos subsequentes.
INSERÇÃO DO GÊNERO E DA SEXUALIDADE NO CURRÍCULO MÉDICO COMO FORMA DE PROMOVER A EQUIDADE
Authors: Morais Rian Barreto Arrais Rodrigues de , RAIMUNDO ALINE CRISTINA BATISTUZZI , BARRETO BEATRIZ LIMA , FIENI KEITE ANTUNES , RONDON MARIANA MENEZES 
Published: June 2022

Introdução: Nas unidades de ensino de medicina do país é observado um modelo de ensino pouco flexível, em que o acadêmico não possui autonomia em grande parte do seu processo de estudo-aprendizado. Por um lado, essa metodologia permite sim formar profissionais bem capacitados, entretanto, por outro, impede que o médico desenvolva uma visão mais humana, cuidadosa e reflexiva com cada futuro paciente. Um grande exemplo, são as temáticas de gênero e sexualidade, as quais são superficialmente abordadas no ensino acadêmico, mas são de extrema importância para a vida profissional do médico. Objetivo: O principal objetivo desse trabalho é abordar uma perspectiva sobre a inserção de uma disciplina de gênero e sexualidade na grade curricular da graduação de medicina, analisando a necessidade de inclusão dos fatores humanos e sociais na promoção em saúde e na educação médica. Material e Método: Foram utilizadas as bases de dados da Scientific Electronic Online (Scielo), biblioteca nacional dos Estados Unidos (Pubmed), dentro do período de 2010 a junho de 2021. Foram revisados estudos publicados na língua inglesa e portuguesa que abordassem a discussão de gênero e sexualidade no âmbito acadêmico, principalmente na formação médica. A seleção da bibliografia, ainda, foi baseada no título, relevância e descrição do trabalho. Resultados: Dentre os estudos analisados ficou claro que a sexualidade é compreendida nos aspectos biológicos, psíquicos e sociais e, assim deve ser incluída no campo da saúde a partir do seu reconhecimento como um aspecto fundamental na educação médica e na promoção em saúde. Discussão: A maior parte dos artigos analisados mostrou a necessidade da abordagem do gênero e da sexualidade de forma a promover a interdisciplinaridade entre os campos das ciências humanas e sociais com a ciência biológica, para que tanto docentes como discentes possam expandir esse debate alargando as fronteiras do conhecimento acadêmico. Conclusão: Portanto, para que, de fato, tenha-se uma perspectiva para além da abordagem exclusivamente biológica, evidenciou-se que é necessário promover um diálogo interdisciplinar entre as ciências biológicas, exatas e humanas no âmbito acadêmico, ampliando, desse modo, aquilo que a visibilidade seletiva à patologia e aos aspectos técnicos da prática médica restringem.
FREQUÊNCIA DE BACTÉRIAS ISOLADAS DO SISTEMA TEGUMENTAR DE PEQUENOS ANIMAIS
Authors: Silva Eliane Ribeiro da , BOSSARDI MELISSA , LIMA DIANE ALVES , CHAGAS PIETRO MARIA , SILVA LETICIA DA 
Published: June 2022

Introdução: As constantes mudanças nos hábitos sociais e culturais se criou um vínculo, muitas vezes familiar, entre os homens e os animais, principalmente os domésticos como cães e gatos sendo que essa ligação requer inúmeros cuidados, que se não exercidos geram uma série de consequências para ambas as espécies tornando extremamente relevante para a saúde pública, uma vez que os animais são possíveis fontes de infecção. Objetivo: O objetivo desse estudo foi identificar as bactérias isoladas no sistema tegumentar de cães e gatos de amostras enviadas a um laboratório veterinário de Caxias do Sul no período de janeiro de 2021 a janeiro de 2022. Material e Método: Foi realizado um estudo retrospectivo de 94 laudos de cultura e antibiograma, onde foi utilizado uma gama de antimicrobianos de diferentes classes para avaliar a susceptibilidade, porém nem todos os microrganismos foram testados para os mesmos antimicrobianos. Resultados: Os isolados de cães e gatos foram analisados de forma conjunta, decorrente ao baixo número de isolados oriundos de felinos 5,31% (5/94). O estudo avaliou a presença de 14 gêneros isolados, onde Staphylococcus spp. foi o gênero bacteriano mais frequente, representando mais de 65% dos isolados (62/94) com diferente caracterização quanto a coagulase (Staphylococcus sp. coagulase negativa 37,25% (35/94) e Staphylococcus sp coagulase positiva 28,73% (27/94) seguido de Proteus sp. (6,40%), E. coli (5,32%) e Klebsiella sp. (4,26%) como os gêneros Gram-negativos mais frequentes. Os demais gêneros foram isolados em menor número, caracterizando um número amostral inferior a 3%. Conclusão: A cultura e antibiograma são exames complementares de grande relevância, uma vez que permitem a identificação das bactérias envolvidas no processo infeccioso, além de determinar o perfil de sensibilidade desses sendo a identificação e caracterização destes isolados cruciais para a escolha do melhor método para avaliação de sensibilidade assim como determinar o conjunto de antimicrobianos a serem testados, acordando as diretrizes utilizadas por cada laboratório.
Conservation and development of human resources through the return migration policy
Authors: Ryndzak Olha , Bachynska Mariia 
Published: June 2022

Purpose. The purpose of the article is to develop the theoretical and methodological foundations for the study of return migration policy based on its information support, including regression analysis and authors’ sociological research on return intentions of Ukrainian migrants.
Methodology / approach. The mathematical tools were used for the assessment of Ukraine’s economical losses, related to migration. With the help of the sociological method (survey) migrants’ intentions and main motives to return were investigated. Stepwise regression model was built for identification of main factors of Ukrainian population’s international migration. Besides, general scientific methods were used in the study, such as: analysis, generalization, systematization, tabular and graphical.
Results. Analysis showed the lack of statistical and sociological information on international migration (particularly return migration) of Ukrainian population. It substantiates the need for improving the system of information provision of migration policy. The results of the survey of the migrants from the Carpathian region of Ukraine (conducted in 2020) show low level of their readiness to return. According to the answers to the questionnaire, there are two main circumstances that could motivate migrants to return: high level of wages and general improving of economic situation in Ukraine. Due to the regression model it was found that the emigration of the population is influenced by the following factors: average monthly wages, gross regional product per capita, foreign direct investment per economically active person and the share of the population with incomes below the subsistence level. The article provides main benefits and ways of implementation of the return migration policy. Particularly, circular migration is considered as a good way to slow down losses of human resources. It is beneficial for all institutional units of the migration process.
Originality / scientific novelty. The methodology for the consequences of international migration study is improved. In particular, the formula for determination of migration losses through the calculation of economic activity losses is proposed and calculated for the first time. The theoretical foundation of return migration policy is developed. In particular, the model of return migration process on the individual level is elaborated. The sociological tool for the return migration investigation is developed and tested.
Practical value / implications. The practical recommendations for the human resources conservation are worked out. The questions for the survey, developed by the authors, could be used in further investigations in this issue. The model of return migration process is useful for developing a comprehensive return migration policy, which could support migrants at all stages of this process: decisions making, movement and reintegration.
Forecasting agricultural commodity price using different models: a case study of widely consumed grains in Nigeria
Authors: Sanusi Olajide I. , Safi Samir K. , Adeeko Omotara , Tabash Mosab I. 
Published: June 2022

Purpose. This study highlights the specific and accurate methods for forecasting prices of commonly consumed grains or legumes in Nigeria based on data from January 2017 to June 2020.
Methodology / approach. Different models that include autoregressive integrated moving average (ARIMA), artificial neural networks (ANN), seasonal decomposition of time series by loess method (STLM), and a combination of these three models (hybrid model) were proposed to forecast the sample grain price data. This study uses price data on widely consumed grains, such as white maize, local rice, imported rice, and white beans, in Nigeria from January 2017 to June 2020.
Results. Our result indicates that ARIMA is the best applicable model for white maize and imported rice because it is well fitted to stationary data, as demonstrated in the sample period. The STLM is more appropriate in forecasting white beans. As white beans are highly seasonal in Nigeria, it further explains why the STLM model fits better in forecasting prices. The production of local rice is inconsistent in Nigeria because of erratic rainfall and stiff competition from the importation of rice from other countries. Therefore, and consistent with the analysis, the hybrid model is the best model applicable to local rice because it captures varying trends exhibited in the data.
Originality / scientific novelty. This study suggests most accurate forecasting techniques for specific agricultural commodities in sub-Saharan African countries. It considers forecasting prices of commonly consumed grains and legumes in Nigeria and traded worldwide, such as imported rice, local rice, beans, and maize.
Practical value / implications. The study highlights the importance of appropriate forecasts for policymakers, producers, and consumers to enhance better decision making and serve as an underlying incentive to guide the allocation of financial resources to the agricultural sector, which determines the structure and degree of sectoral growth.
Financial well-being of territorial communities and the economic growth of the regions of Ukraine: assessment and modeling of interrelation
Authors: Voznyak Halyna , Mulska Olha , Bil Mariana , Patytska Khrystyna , Lysiak Liubov 
Published: June 2022

Purpose. The purpose of the article to assess and model the interrelation between the financial well-being of territorial communities (TCs) and regional economic growth in Ukraine under conditions of uncertainty.
Methodology / approach. The empirics of assessment and modeling of a causal relationship between the financial well-being of TCs and economic growth of regions is based on: the construction of time series for empirical parameters of territorial communities’ financial well-being (substantiation of structural elements of financial well-being, TCs clusterization by the criteria of profitability, and calculation of integral coefficients); multidimensional estimation of regional economic growth (multiplicative approach, principal component analysis); detection of impact (“pressure” force) of TCs’ financial well-being on the paces of regional economic growth (index and regression methods).
Results. Based on the results of the integral assessment with preliminary clusterization of TCs by their revenues, the article reveals that in 2020, the weighted average level of TCs’ financial well-being in Ukrainian regions was the highest in Zakarpattia (0.592), Kherson (0.534), Zaporizhzhia (0.513), and Chernivtsi (0.512) oblasts, while the lowest – in Ivano-Frankivsk (0.281) oblast. In 2010–2020, Ivano-Frankivsk (0.48 %), Poltava (0.06 %), Rivne (0.16 %), Ternopil (0.25 %), Khmelnytskyi (0.35 %), and Chernihiv (0.54 %) oblasts demonstrated higher annual average economic growth paces, while Dnipropetrovsk (-0.86 %) and Kherson (-0.94 %) oblasts – negative ones.
Originality / scientific novelty. The article enhances the methodological approach to the complementary assessment of TCs’ financial well-being and regional economic growth, which has contributed to modeling the ability of territories’ economies to increase investment-economic capacity and the causal relationship between economic growth determinants and the financial capacity of territorial communities in regions.
Practical value / implications. The article offers and substantiates the action-oriented approach to the assessment of regional economic development. Its implementation contributes to making the spatial breakdown of the system’s economic condition and building the architectonics of economic progress determinants to determine the “divergence areas” of regional development.
Description and evaluation of the tropospheric aerosol scheme in the Integrated Forecasting System (IFS-AER, cycle 47R1) of ECMWF
Authors: Rémy Samuel , Kipling Zak , Huijnen Vincent , Flemming Johannes , Nabat Pierre , Michou Martine , Ades Melanie , Engelen Richard , Peuch Vincent-Henri 
Published: June 2022

Abstract. This article describes the Integrated Forecasting System aerosol scheme (IFS-AER) used operationally in the IFS cycle 47R1, which was operated by the European
Centre for Medium Range Weather Forecasts (ECMWF) in the framework of the Copernicus Atmospheric Monitoring Services (CAMS). It represents an update
of the Rémy et al. (2019) article, which described cycle 45R1 of IFS-AER in detail. Here, we detail only the parameterisations of sources and sinks that
have been updated since cycle 45R1, as well as recent changes in the configuration used operationally within CAMS. Compared to cycle 45R1, a
greater integration of aerosol and chemistry has been achieved. Primary aerosol sources have been updated, with the implementation of new dust and
sea salt aerosol emission schemes. New dry and wet deposition parameterisations have also been implemented. Sulfate production rates are now
provided by the global chemistry component of IFS. This paper aims to describe most of the updates that have been implemented since cycle 45R1,
not just the ones that are used operationally in cycle 47R1; components that are not used operationally will be clearly flagged. Cycle 47R1 of IFS-AER has been evaluated against a wide range of surface and total column observations. The final simulated products, such as
particulate matter (PM) and aerosol optical depth (AOD), generally show a significant improvement in skill scores compared to results obtained
with cycle 45R1. Similarly, the simulated surface concentration of sulfate, organic matter and sea salt aerosol are improved by cycle 47R1 compared to cycle 45R1. Some biases persist, such as the surface concentrations of nitrate and organic matter being simulated too high. The new wet and dry
deposition schemes that have been implemented into cycle 47R1 have a mostly positive impact on simulated AOD, PM and speciated aerosol surface
concentration.
Different drought types and the spatial variability in their hazard, impact, and propagation characteristics
Authors: Tijdeman Erik , Blauhut Veit , Stoelzle Michael , Menzel Lucas , Stahl Kerstin 
Published: June 2022

Abstract. Droughts often have a severe impact on the environment, society, and the economy. The variables and scales that are relevant to understand the impact of drought motivated this study, which compared hazard and propagation characteristics, as well as impacts, of major droughts between 1990 and 2019 in southwestern Germany. We bring together high-resolution datasets of air temperature, precipitation, soil moisture simulations, and streamflow and groundwater level observations, as well as text-based information on drought impacts. Various drought characteristics were derived from the hydrometeorological and drought impact time series and compared across variables and spatial scales. Results revealed different drought types sharing similar hazard and impact characteristics. The most severe drought type identified is an intense multi-seasonal drought type peaking in summer, i.e., the events in 2003, 2015, and 2018. This drought type appeared in all domains of the hydrological cycle and coincided with high air temperatures, causing a high number of and variability in drought impacts. The regional average drought signals of this drought type exhibit typical drought propagation characteristics such as a time lag between meteorological and hydrological drought, whereas propagation characteristics of local drought signals are variable in space. This spatial variability in drought hazard increased when droughts propagated through the hydrological cycle, causing distinct differences among variables, as well as regional average and local drought information. Accordingly, single variable or regional average drought information is not sufficient to fully explain the variety of drought impacts that occurred, supporting the conclusion that in regions as diverse as the case study presented here, large-scale drought monitoring needs to be complemented by local drought information to assess the multifaceted impact of drought.
Green synthesis of ZnO nanoparticles using the leaf extract of Lavandula angustifolia and evaluation of their antibacterial activity against human pathogens
Authors: Rather Gulzar Ahmed , Nanda Anima , Raj Ezekiel , Mathivanan Narayanasamy , Nayak B. K. 
Published: June 2022

The present study was aimed to the biosynthesis of Zinc oxide nanoparticles using leaf extract of Lavandula angustifolia. The nanoparticles were characterized by different techniques like UV-Visible spectroscopy, FESEM analysis, and X-ray diffraction. From the UV-Visible spectra analysis, it was observed the peak obtained at 350 nm confirmed the biosynthesis of LA-ZnONPs. The shape and size of LA-ZnONPs were confirmed by FESEM analysis, and from FESEM analysis it was found that the LA-ZnONPs were truncated and triangular in shape with an average size of 61.52 nm respectively. Further, the XRD analysis showed the LA-ZnONPs were crystalline in nature. By using well diffusion assay, the antibacterial activity of LA-ZnONPs was investigated against gram-positive S. aureus (ATCC 25923) and gram-negative E. coli (ATCC 11229) pathogens in a dose-dependent manner. The LA-ZnONPs exhibited excellent antibacterial activity against both the pathogens. The LA-ZnONPs thus possessed excellent antibacterial activity against human pathogens and can be used in drug development
Vrijheid de uitzondering, beperking de regel: de strafbaarstelling van het verblijven in een door een terroristische organisatie gecontroleerd gebied
Authors: Faber Tom , van Noorloos Marloes 
Published: June 2022

Freedom the exception, restriction the rule: criminalisation of staying in an area controlled by a terrorist organization
This article deals with the legislative proposal in the Netherlands to criminalise staying (without permission) in an area controlled by a terrorist organisation. The discussion surrounding the proposal is focused, amongst other things, on possible exemptions for journalists and providers of humanitarian assistance. This article analyses the newest version of the proposal in light of the rights to freedom of movement and freedom of expression.
De weigering van een jachtakte door de korpschef van de politie als een bestraffende sanctie?
Authors: van der Vorm B. 
Published: June 2022

De weigering van een jachtakte door de korpschef van de politie als een bestraffende sanctie? Annotatie bij ABRvS 4 augustus 2021, ECLI:NL:RVS:2021:1748
Door de korpschef van de politie is geweigerd een jachtakte te verlenen. De reden hiervoor ligt in het feit dat de aanvrager van de jachtakte is veroordeeld wegens overtreding van de Wet wapens en munitie. Op grond hiervan mag de korpschef geen jachtakte verlenen aan de aanvrager. Voorts is deze weigering niet aan te merken als een bestraffende sanctie.
De zaak Gündoğan/Volt: rechter, politiek en de zoektocht naar institutionele grenzen
Authors: Vetzo M.J. 
Published: June 2022

De zaak Gündoğan/Volt: rechter, politiek en de zoektocht naar institutionele grenzen
De stelling in deze aflevering van TvCR luidt: ‘In de zaak Gündoğan/Volt wreekte zich het ontbreken van een fatsoenlijke wettelijke regeling over het functioneren van Kamerfracties.’
Max Vetzo pleit tegen deze stelling.
Volgens hem schuilt het probleem niet in het ontbreken van objectieve wettelijke normen, maar in institutionele onduidelijkheid over de vraag welke rol de rechter in geschillen over het fractielidmaatschap van Kamerleden toekomt.