bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lustrous wrappings: Complex color and collaborative practices in the contemporary ceramic facade
Authors: McLachlan Fiona , Lyu Mengmeng , Leng Xuechang 
Published: November 2022

AbstractGlazed ceramic cladding is a material with a very long history of use in the built environment, whether as roof tiles, wall tiles, or more recently, as part of a rainscreen cladding system. A key factor in the resurgence of interest in ceramic as a cladding material—in addition to its inherent qualities of sustainability, malleability, durability, and fire resistance—is as a means of incorporating color into the facade. Although polychromatic facades are commonly achieved using tessellation of a range of single‐colored elements, this article will focus on complex layered and variegated color and texture within a single component. Historical glazes, such as the blue‐red of Chinese Jun ware pottery from the 12th century CE were produced through carefully controlled reduction kiln processes, yet retained an element of uncertainty in the resultant patterns and remain an inspiration for contemporary ceramic artists. Drawing on historical research, literature review and interviews with ceramic artists and industrial manufacturers, six case studies from the United Kingdom and China are discussed that show collaborative processes at different scales of operation. These combine unique artisan and artistic glazes, with standardized, rigorously tested, and internationally manufactured products. These “fusion glazes” refer to historic hand‐made practices to bring an element of unpredictability, and a layer of complexity in terms of color, texture and luster.
Effect of Pevonedistat, an Investigational NEDD8‐Activating Enzyme Inhibitor, on the QTc Interval in Patients With Advanced Solid Tumors
Authors: Zhou Xiaofei , Richardson Debra L. , Dowlati Afshin , Goel Sanjay , Sahebjam Solmaz , Strauss James , Chawla Sant , Wang Ding , Mould Diane R. , Samnotra Vivek , Faller Douglas V. , Venkatakrishnan Karthik , Gupta Neeraj 
Published: November 2022

AbstractThe purpose of this study was to assess the effect of pevonedistat, a neural precursor cell expressed, developmentally down‐regulated protein 8 (NEDD8)‐activating enzyme inhibitor, on the heart rate‐corrected QT (QTc) interval in cancer patients. Patients were randomized 1:1 to receive pevonedistat 25 or 50 mg/m2 on day 1 and the alternate dose on day 8. Triplicate electrocardiograms were collected at intervals over 0–11 hours and at 24 hours via Holter recorders on days −1 (baseline), 1, and 8. Changes from time‐matched baseline values were calculated for QTc by Fridericia (QTcF), PR, and QRS intervals. Serial time‐matched blood samples for analysis of pevonedistat plasma pharmacokinetics were collected and a concentration–QTc analysis conducted. Safety was assessed by monitoring vital signs, physical examinations, and clinical laboratory tests. Forty‐four patients were included in the QTc analysis. Maximum least square (LS) mean increase from time‐matched baseline in QTcF was 3.2 milliseconds at 1 hour postdose for pevonedistat at 25 mg/m2, while the LSs mean change from baseline in QTcF was −1.7 milliseconds 1 hour postdose at 50 mg/m2. The maximum 2‐sided 90% upper confidence bound was 6.7 and 2.9 milliseconds for pevonedistat at 25 and 50 mg/m2, respectively. Pevonedistat did not result in clinically relevant effects on heart rate, nor on PR or QRS intervals. Results from pevonedistat concentration–QTc analysis were consistent with these findings. Administration of pevonedistat to cancer patients at a dose of up to 50 mg/m2 showed no evidence of QT prolongation, indicative of the lack of clinically meaningful effects on cardiac repolarization. ClinicalTrials.gov identifier: NCT03330106 (first registered on November 6, 2017).
Trophic strategies of intertidal foraminifera explored with single‐cell microbiome metabarcoding and morphological methods: What is on the menu?
Authors: Schweizer Magali , Jauffrais Thierry , Choquel Constance , Méléder Vona , Quinchard Sophie , Geslin Emmanuelle 
Published: November 2022

AbstractIn mudflats, interactions and transfers of nutrients and secondary metabolites may drive ecosystems and biodiversity. Foraminifera have complex trophic strategies as they often rely on bacteria and eukaryotes or on potential symbionts for carbon and nitrogen resources. The capacity of these protists to use a wide range of adaptive mechanisms requires clarifying the relationships between them and their microbial associates. Here, we investigate the interactions of three foraminiferal species with nearby organisms in situ, by coupling molecular (cloning/Sanger and high‐throughput sequencing) and direct counting and morphological identification with microscopy. This coupling allows the identification of the organisms found in or around three foraminiferal species through molecular tools combined with a direct counting of foraminifera and diatoms present in situ through microscopy methods. Depending on foraminiferal species, and in addition to diatom biomass, diatom frustule shape, size and species are key factors driving the abundance and diversity of foraminifera in mudflat habitats. Three different trophic strategies were deduced for the foraminifera investigated in this study: Ammonia sp. T6 has an opportunistic strategy and is feeding on bacteria, nematoda, fungi, and diatoms when abundant; Elphidium oceanense is feeding mainly on diatoms, mixed with other preys when they are less abundant; and Haynesina germanica is feeding almost solely on medium‐large pennate diatoms. Although there are limitations due to the lack of species coverage in DNA sequence databases and to the difficulty to compare morphological and molecular data, this study highlights the relevance of combining molecular with morphological tools to study trophic interactions and microbiome communities of protists at the single‐cell scale.
Large variability in response to future climate and land‐use changes among Chinese Theaceae species
Authors: Tang Junfeng , Zhao Xuzhe 
Published: November 2022

AbstractTheaceae is an important family in the phylogeny of angiosperm in China, which are potentially threatened by future changes in climatic and land use conditions. Therefore, understanding and predicting the isolated and combined effects of these two global change factors on Theaceae species is crucial for biodiversity conservation. Here, we assessed the isolated and combined effects of climate and land use change on the distribution shifts of 95 Theaceae species under different future scenarios by comparing projections of three model configurations: (1) dynamics climate and constant land use variables; (2) constant climate and dynamics land use variables; and (3) dynamics climate and dynamics land use variables. We find that all the three types of models predicted range contractions for most of the 95 Theaceae species under all future scenarios. Moreover, we find that climate change has rather strong effect for most species while land use change has nonsignificant or weak effect on future species distributions, although both of these two isolated effects are highly variable across individual species. Finally, the combined effect of these two factors reveals that the land use change may amplify or buffer distribution shifts expected from climate change impact depending on species. These findings emphasize the importance of taking into account the large variability in response to land use change among Theaceae species when developing land‐based conservation strategies in a changing climate.
Inducing fear using acoustic stimuli—A behavioral experiment on moose (Alces alces) in Sweden
Authors: Bhardwaj Manisha , Lodnert Denice , Olsson Mattias , Winsvold Aina , Eilertsen Svein Morten , Kjellander Petter , Seiler Andreas 
Published: November 2022

AbstractPrey species may display anti‐predatory behavior, i.e., flight, increased vigilance, and decreased feeding, in response to the true presence of a predator or to the implied presence of a predator through, e.g., acoustic cues. In this study, we investigated the anti‐predatory reactions of moose (Alces alces) to acoustic stimuli related to hunting, at saltlick stones, a known attractant. In before‐during‐after‐control‐impact experiments, we compared the behavioral responses of individuals to: (i) two hunting‐related acoustic stimuli—hunting dog barking and human speaking; (ii) nonpredatory acoustic stimuli—bird sounds and; and (iii) no acoustic stimulus (control). We asked: (1) How does the probability of moose leaving the site differ depending on the stimulus they are exposed to?; (2) What affect do the acoustic stimuli have on the amount of time moose spend vigilant, feeding, or away from the site?; and (3) What affect do the stimuli have on the time between events at a site? We found that when exposed to the human stimulus, moose left the sites in 75% of the events, which was significantly more often compared to the dog (39%), bird (24%), or silent (11%) events. If moose did not leave the site, they spent more time vigilant, and less time feeding, particularly when exposed to a dog or human stimulus. Furthermore, moose spent the most time away from the site and took the longest to visit the site again after a human stimulus. Moose were also more likely to leave the site when exposed to the bird stimulus than during silent controls. Those that remained spent more time vigilant, but their behaviors returned to baseline after the bird stimulus ended. These findings suggest that acoustic stimuli can be used to modify the behavior of moose; however, reactions towards presumably threatening and nonthreatening stimuli were not as distinct as we had expected.
Multilocus evidence provides insight into the demographic history and asymmetrical gene flow between Ostrinia furnacalis and Ostrinia nubilalis (Lepidoptera: Crambidae) in the Yili area, Xinjiang, China
Authors: Li Bing , Yang Zhaofu 
Published: November 2022

Abstract

Tianshan Mountains provide a model for studying biological evolution and speciation. Here we assess the evolutionary history of Ostrinia furnacalis (ACB) and Ostrinia nubilalis (ECB), which are sympatric in the Yili River Valley in Xinjiang, China.

Our study is based on the historical gene flow analyses of two species by using three mitochondrial DNA (mtDNA, COI, COII, Cytb) and four nuclear DNA (nuDNA, EF‐1α, Wingless, RPS5, CAD) markers obtained from representatives of HC (Huocheng), YN (Yining), XY (Xinyuan), and MNS (Manasi).

Our results reveal that there is an asymmetrical gene flow pattern between the four populations. The population migratory pathways between these different populations show inflow into HC and YN, outflow from XY, and that MNS maintained a flow balance. Bayesian divergence time dating based on the COI gene suggests that the genetic divergence between the two species in this area may have occurred in Holocene at 0.008 Mya. Neutrality tests (Tajima's D, Fu's Fs), and mismatch distribution test results suggest that population expansion events may not have occurred in the recent past. The demographic history and gene flow pattern between ACB and ECB may follow the “mountain isolation” hypothesis. The ML and BI trees of the mtDNA haplotype dataset show that ECB haplotypes are grouped together in a distinct clade and are clearly separate from ACB haplotypes. However, the geographical pattern of haplotype distribution is less clear for both ACB and ECB, supporting that there has been frequent gene flow among the geographic populations in the Tianshan Mountains.

These findings indicate that the Tianshan Mountains are less likely a barrier to gene flow of the two species.
Disentangling genetic from environmental effects on phenotypic variability of southern rock lobster (Jasus edwardsii) postlarvae
Authors: Villacorta‐Rath Cecilia , Green Bridget S. , Gardner Caleb , Murphy Nick P. , Souza Carla A. , Strugnell Jan M. 
Published: November 2022

AbstractEnvironmental conditions experienced during the larval dispersal of marine organisms can determine the size‐at‐settlement of recruits. It is, therefore, not uncommon that larvae undergoing different dispersal histories would exhibit phenotypic variability at recruitment. Here, we investigated morphological differences in recently settled southern rock lobster (Jasus edwardsii) recruits, known as pueruli, along a latitudinal and temporal gradient on the east coast of Tasmania, Australia. We further explored whether natural selection could be driving morphological variation. We used double digest restriction site‐associated DNA sequencing (ddRADseq) to assess differences in the genetic structure of recently settled recruits on the east coast of Tasmania over 3 months of peak settlement during 2012 (August–October). Phenotypic differences in pueruli between sites and months of settlement were observed, with significantly smaller individuals found at the northernmost site. Also, there was a lack of overall genetic divergence; however, significant differences in pairwise FST values between settlement months were observed at the southernmost study site, located at an area of confluence of ocean currents. Specifically, individuals settling into the southernmost earlier in the season were genetically different from those settling later. The lack of overall genetic divergence in the presence of phenotypic variation indicates that larval environmental history during the dispersal of J. edwardsii could be a possible driver of the resulting phenotype of settlers.
Using a convolutional neural network model to derive imaging landmarks for lumbar spine numbering on axial magnetic resonance images
Authors: Yoon Heewon , Cho Yongwon , Ahn Kyung‐Sik , Lee Hee‐Gone , Kang Chang Ho , Park Beom Jin 
Published: November 2022

AbstractUnderstanding the axial lumbar spine anatomy, including knowledge of the relationship between the lumbar spine level and other paraspinal structures, is important for diagnosing and treating diseases. The purpose of this study was to validate the accuracy of a convolutional neural network (CNN) model in lumbar spine level numbering on axial magnetic resonance (MR) images and to find the appropriate anatomic landmarks for numbering using a class activation map (CAM). A total of 6055 axial MR images of the lumbar spine from the L1‐2 to L5‐S1 disc levels were obtained to train and validate the CNN model. MR images were acquired using three 3‐Tesla machines. The algorithm was developed with three models, and the best‐performing model was selected. The external validation set (n = 493) was obtained from other institutions using various machines. The accuracy of the numbering was analyzed using a confusion matrix and receiver operating characteristic curves. The CAMs were reviewed, and the identified anatomic structures were investigated. A reader study was performed by three radiologists, and their accuracy was compared with that of the model. The overall accuracy of the best‐performing model for lumbar spine numbering was 0.98 on internal validation and 0.95 on external validation. For the CAM review, mappings concentrated on both paraspinal areas, including the kidney, back muscles, and ilium according to the level. Top‐1 and top‐2 accuracies of the reviewers ranged between 0.56–0.75, and 0.84–0.93, respectively. After reviewing the CAMs, the accuracy increased to 0.75–0.78 and 0.93–0.98, respectively. A CNN model can accurately determine the level of the lumbar spine on axial MR images, and the configuration of muscles can be used to determine the lumbar level.
Mechanisms fostering the sustainability of actualized value propositions of implementede‐Governmentprojects inSub‐SaharanAfrica: A realist evaluation case of Nigeria and Rwanda
Authors: Chidama Yusuf Ephraim , Ononiwu Chidi Gerard 
Published: November 2022

AbstractThis study examines the mechanisms fostering sustainable value propositions of implemented e‐Governments projects in sub‐Saharan Africa (SSA) as a research focus. Value propositions identify how public organizations use e‐Government to fulfill citizens' needs across different roles. Using a concept‐centric systematic review, we identified such value propositions as effective public organizations, quality service delivery, open government and democratic values, as well as social values and well‐being. We chose some selected e‐Government projects in Nigeria and Rwanda; adopted realist evaluation (RE) multiple case studies as a methodology and introduced affordance actualization, self‐determination theory, and sustainability framework for e‐Government success as theoretical lenses. To collect data, we adopted a mixed method RE approach and used a contingent valuation method (CVM) as a quantitative aspect to identify the actualized value propositions in operations in the implemented e‐Government projects in Nigeria and Rwanda as outcomes. Sequentially followed by a realist interview as a qualitative approach to collect and analyze data we uncovered the generative mechanisms causing such outcomes to exist and be sustainable. Our findings revealed technological cognizance and autonomy as well as competence as individual mechanisms identified for sustaining such outcomes. While organizational mechanisms revealed are continuous availability of funds, institutional, administrative, and coordinating capacity with leadership and political support. Other organizational mechanisms include institutionalizing the technology within local settings with ongoing monitoring and improvement evaluation enabled by both internal and external contextual conditions. We synthesized our findings into an actualized value sustainability framework for implemented e‐Government projects in SSA to contribute to academics and practice in ICT4D, particularly RE application in e‐Government study, which is nascent.
Polyetherimide‐ and folic acid‐modifiedFe3O4nanospheres for enhanced magnetic hyperthermia performance
Authors: Wang Qinganzi , Cheng Yuemei , Wang Wenhua , Tang Xiaolin , Yang Yongxiu 
Published: November 2022

AbstractRecent studies have highlighted the development prospects of magnetic hyperthermia in cancer therapy. A few studies on the application of Fe3O4nanospheres for the magnetic hyperthermia of gynecological malignancies have achieved certain efficacy, but there was no visible progress currently. In this work, Fe3O4nanospheres modified with polyetherimide (PEI) and folic acid (FA) were synthesized using a hydrothermal method for possible utility in biocompatible and active tumor‐targeting magnetic induction hyperthermia. The PEI‐ and FA‐coated Fe3O4nanospheres showed high crystallinity, well‐dispersed spherical structures and idealMsvalue. As a result, the designed Fe3O4@ PEI@FA nanospheres achieved higher specific absorption rate (SAR) values at 360 kHz and 308 Oe, as well as excellent biocompatibility in Hela, SKOV3, HEC‐1‐A and NIH3T3 cells. These nanospheres can be used as an optimal heating agent for the magnetic hyperthermia treatment of gynecological cancers.
The Arterial Pattern of the Upper Nasal Septum (S‐Point) and Potential Role in Severe Epistaxis
Authors: Rezende Natália Cerqueira , Leonel Luciano C.P.C. , Kosugi Eduardo Macoto , Pinheiro‐Neto Carlos Diógenes , Peris‐Celda Maria 
Published: November 2022

ObjectivesThe previously described S‐point, corresponds to the medial projection of the middle turbinate axilla in the superior nasal septum and has been identified as a common source of severe epistaxis. The objective is to define the anatomical patterns of vascularization of the S‐point area that could explain its clinical relevance.MethodsThirty‐three nasal septums of latex‐injected formalin‐embalmed and fresh human cadaveric heads were dissected to analyze the arterial arrangement of the S‐point area. Measurements and patterns of vascularization were described.ResultsThe S‐point area, was consistently surrounded by a single or multiple arterial anastomotic arches consistently formed superiorly by the anterior ethmoidal and posterior ethmoidal artery branches, and inferiorly by the posterior septal artery. The caliber of the arterial arches was typically larger than the caliber of the arterial branches supplying them. A single arch was present in 36.3% of septums, and multiple arches in 63.6%. The mean distance from the S‐point to the anterior limit of the arch was 9 mm, to the posterior arch when the present was 3 mm, to the superior limit 6 mm, to the inferior limit 6 mm, and to the nasal roof was 10 mm.ConclusionThis study demonstrates the dense arterial configuration of the S point area, which is characterized by a single or multiple vascular arches of greater caliber than the branches of origin. This finding could explain why the S‐point area is a frequent source of epistaxis, and guide its surgical cauterization when an obvious vascular ectasia is not visualized.Level of EvidenceN/A Laryngoscope, 133:2075–2080, 2023
A Self‐Pumping Dressing with Multiple Liquid Transport Channels for Wound Microclimate Management
Authors: Zhu Hai , Zhi Chao , Meng Jiaguang , Wang Yongzhen , Liu Yaming , Wei Liang , Fu Sida , Miao Menghe , Yu Lingjie 
Published: November 2022

AbstractA microclimate with ventilation and proper wettability near the wound is vital for wound healing. In the case of pressure or absorption of large amounts of wound exudate, maintaining air circulation around the wound is currently a challenge for wound dressings. In this study, a novel self‐pumping dressing (FAED) with multiple liquid transport channels is designed by combining a 3D spacer fabric, sodium alginate aerogel, and electrospun membrane. This unique structural design allows FAED to unidirectionally rapidly remove excess biofluid from the wound and transfer it through a special liquid transport channel to a liquid storage layer with a high absorption ratio. Importantly, the air circulation layer of FAED composed of liquid transport channels and spacer yarns provides excellent air permeability in both the horizontal (12.3 L min−1) and vertical (272.02 mm s−1) directions. Additionally, a lower compression modulus (0.14 MPa) and higher compression strength (0.15 MPa) enable the novel dressing to adapt to body contours and provide good supporting performance, as compared to foam dressings. Combined with its high biocompatibility, this unique dressing has significant potential for wound treatment and intensive care.
Modification of CNF‐Networks by the Addition of Small Amounts of Well‐Defined Rigid Cationic Nanolatexes
Authors: Alexakis Alexandros Efraim , Jerlhagen Åsa , Leggieri Maria Rosella Telaretti , Eliasson Adrian , Benselfelt Tobias , Malmström Eva 
Published: November 2022

AbstractCellulose nanofibril (CNF)‐networks are modified by the addition of small amounts (below 10 wt%) of well‐defined cationic nanolatexes synthesized through reversible addition–fragmentation chain‐transfer‐mediated polymerization‐induced self‐assembly (PISA). Minute amounts of nanolatex inclusions lead to increased tensile and shear moduli, indicating that nanolatexes can act as bridging‐points between CNFs. At higher nanolatex content, this stiffening effect is lost, likely due to interactions between nanolatexes leading to plasticization. The influence of nanolatex content and size on interparticle distance is discussed and is used as a tool to understand the effects observed in macroscopic properties. Upon annealing, the stiffening effect is lost due to the softening of the nanolatexes, indicating that the core–shell morphology is a prerequisite for this effect. These systems form a versatile platform to develop fundamental insights into complex condensed colloidal systems, to ultimately aid in the development of new sustainable material concepts.