bluuebunny/crossref_metadata_2025_split huggingface dataset:
СТРУКТУРА Й ХАРАКТЕРИСТИКИ МУЛЬТИМОДАЛЬНОЇ ДОСТАВКИ З ПОЗИЦІЇ ЦИФРОВІЗАЦІЇ
Authors: Berestenko V.V. , Onyshchenko S.P. 
Published: January 2022

Вступ. Найближчий час – це період цифровізації транспортної логістики та ланцюгів постачань, що вимагає специфічної структуризації й моделювання тих об’єктів і процесів, які раніше не досліджувалися із цієї точки зору. Це є першим етапом руху в бік цифровізації, сутність якого – стандартизація структур не тільки документів, а й об’єктів і процесів. Для цифровізації мультимодальних доставок необхідна чітка ідентифікація структури й характеристик мультимодальної доставки, тобто формування системної моделі такої доставки. Це, у свою чергу, дасть змогу розглядати доставку не тільки локально в рамках певних цифрових рішень, а й інтегровано множину доставок мультимодального оператора з метою пошуку джерел підвищення ефективності, наприклад, на базі використання ефекту синергізму. Метою дослідження є формування системного уявлення мультимодальної доставки з урахуванням різних її аспектів, установлення основних характеристик доставки як інтегральних величин на базі її системного уявлення. Результати. Ідентифікована структура мультимодальної доставки відповідно до багатоаспектного погляду на неї. Як утворювальний елемент для подальшого дослідження з урахуванням специфіки цифровізації обрана «операція» транспортно-технологічного процесу, яка може бути виконана різними суб’єктами транспортного ринку. Побудовано основні можливі варіанти фізичного переміщення вантажу та пунктів змін транспортного засобу. Послідовність операцій пропонується уявляти у вигляді сіткової моделі, яка дає змогу з урахуванням основних характеристик кожної операції – часу, вартості й надійності – визначати підсумкові характеристики доставки в цілому. Запропоновано два підходи до визначення надійності доставки залежно від наявної статистичної інформації. Висновки. З урахуванням характеристик кожної компоненти альтернативного варіанта доставки формуються його підсумкові показники – вартість, час і надійність, які є базою для прийняття рішення щодо вибору відповідного варіанта. Зміна хоча б одного елемента в цій системі призводить до зміни характеристик усієї доставки. Це використовується для коригування варіантів у процесі пошуку того варіанта, який би відповідав вимогам, що висуваються.
Pemetaan Kelompok Sebaran Titik Gempa Bumi Mentawai Dengan Metode K-Medoids Clustering
Authors: Setiawan Yudi , Suprianto Safroni Aziz , Wijanarko Andang , Rini Dyah Setyo , Yusa Mochammad 
Published: January 2022

Secara geologis Kepulauan Indonesia berada pada jalur penumjaman lempeng bumi, seperti penunjaman Lempeng Samudra Indo-Australia dengan Lempeng Benua Eurasia yang memanjang dari pantai barat Sumatera hingga pantai selatan Jawa terus ke timur sampai Nusa Tenggara. Jalur penunjaman lempeng bumi di wilayah Kepulauan Indonesia merupakan jalur penyebab gempa tektonik yang mana bersifat regional dan umumnya kerusakan yang ditimbulkan sangat parah. Sebagian jalur gempa bumi tersebut berada di laut sehingga sangat berpotensi menimbulkan bencana tsunami . Di Indonesia sendiri, Daerah yang sangat rawan terjadinya gempa bumi dari dasar laut adalah Kepulauan Mentawai di Sumatera Barat. Pada tahun 2010 Mentawai mengalami sejumlah gempa, yaitu gempa berkekuatan 6,8 SR pada 5 Maret 2010, disusul 6.5 SR pada 5 Mei 2010 dan terakhir gempa berkekuatan 7,8 SR pada 25 oktober 2010 yang diikuti dengan bencana tsunami. United States Geological Survey (USGS) adalah sebuah agensi ilmiah pemerintah Amerika Serikat yang didirikan pada 3 Maret 1879. Organisasi ini memiliki empat disiplin ilmiah utama, yaitu biologi, geografi, geologi, dan air. Salah satu program dari USGS adalah memonitor aktivitas gempa bumi di seluruh dunia, tak terkecuali data gempa kepulauan mentawai yang disediakan dalam bentuk datasheet. Dengan adanya kemajuan teknologi saat ini, dibutuhkan suatu sistem yang dapat memberikan informasi mengenai pemetaan kelompok sebaran titik gempa bumi mentawai dengan clustering gempa bumi. Penelitian ini bertujuan untuk Membangun Sistem Informasi yang dapat melakukan pemetaan pola sebaran gempa bumi mentawai tahun 2010 – 2019 dan juga bertujuan untuk mengimplementasikan metode K-Medoid Clustering untuk menganalisis dan memetakan pola Sebaran gempa bumi mentawai tahun 2010 – 2019. Untuk memetakan pola sebaran gempa bumi tersebut digunakan dua (2) parameter yaitu kedalaman dan kekuatan gempa bumi dengan menggunakan metode K-Medoid Clustering. Luaran yang dihasilkan berupa layout peta hasil perhitungan dari metode K-Medoids Clustering selama sepuluh (10) tahun yaitu tahun 2010 – 2019 yang terdapat sebanyak 1356 data. Selain itu terdapat juga luaran yang dihasilkan berupa tampilan diagram batang dan diagram lingkaran.
Use of Rapid Drug Desensitization in Delayed Hypersensitivity Reactions to Chemotherapy and Monoclonal Antibodies
Authors: Vega Arantza , Peña M. Isabel , Torrado Inés 
Published: January 2022

Background:Rapid drug desensitization (RDD) allows first-line therapies in patients with immediate drug hypersensitivity reactions (DHR) to chemotherapeutic drugs (ChD) and monoclonal antibodies (mAb). Desensitization in delayed drug reactions has traditionally used slow protocols extending up to several weeks; RDD protocols have been scarcely reported.Patients and Method:We retrospectively analyzed the patients referred to the Allergy Department, who had experienced a delayed DHR (&gt; 6 h) related to a ChD or mAb and underwent an RDD protocol. The rate of successful administration of the offending drug and the presence of adverse reactions were evaluated.Results:A total of 93 RDDs were performed in 11 patients (including 6 men and 5 women, with a median age of 61 years). The primary DHR were maculopapular exanthema (MPE) (8), generalized delayed urticaria (1), MPE with pustulosis and facial edema (1), and facial edema with desquamative eczema (1). The meantime for the onset of symptoms was 3 days (range 1–16 days). RDD was performed using a protocol involving 8–13 steps, with temozolomide (25), bendamustine (4), rituximab (9), infliximab (24), gemcitabine (23), and docetaxel (8), within 4.6–6.5 h. Sixteen breakthrough reactions were reported during the RDD (17.2 %) in 5 patients; all were mild reactions including 11 delayed and 5 immediate reactions. All patients completed their treatment.Conclusions:RDD is a potentially safe and effective procedure in patients suffering from delayed reactions to ChD and mAb. It allows them to receive full treatment in a short period, thereby reducing time and hospital visits.
MFG-E8 Maintains Cellular Homeostasis by Suppressing Endoplasmic Reticulum Stress in Pancreatic Exocrine Acinar Cells
Authors: Ren Yifan , Liu Wuming , Zhang Jia , Bi Jianbin , Fan Meng , Lv Yi , Wu Zheng , Zhang Yuanyuan , Wu Rongqian 
Published: January 2022

Graphical AbstractMFG-E8 alleviate ER stress in pancreatic exocrine acinar cells via αVβ3/5 integrin-FAK-STAT3 pathway.
Zn-Based Deep Eutectic Solvent as the Stabilizing Electrolyte for Zn Metal Anode in Rechargeable Aqueous Batteries
Authors: Thorat Gaurav M. , Ho Van-Chuong , Mun Junyoung 
Published: January 2022

Owing to its low cost and high safety, metallic zinc has received considerable attention as an anode material for zinc aqueous batteries (ZIBs). However, the Zn metal instability as a result ultrafast of obstinate dendrite formation, free-water-induced parasite reactions, and corrosive electrolytes has detrimental effects on the implementation of ZIBs. We present an alternative stable electrolyte for ZIBs based on a zinc chloride/ethylene glycol deep eutectic solvent (DES). This electrolyte consists of abundant low-cost materials and a utilizable Zn2+ concentration of approximately 1 M. It combines the advantages of the aqueous and DES media to provide safe and reversible Zn plating/stripping with a two-fold increase in the cycling life compared to that of conventional aqueous electrolytes. With these advantages, the Zn symmetric cell operates at 0.2 mA cm−2 for 300 h. Due to its high efficiency and compositional versatility, this electrolyte enables the investigation of a non-aqueous electrolyte family for ZIBs that fulfill grid-scale electrical energy storage requirements.
Blood Biomarkers and Serologic Immunological Profiles Related to Periodontitis in Abdominal Aortic Aneurysm Patients
Authors: Salhi Leila , Rijkschroeff Patrick , Van Hede Dorien , Laine Marja L. , Teughels Wim , Sakalihasan Natzi , Lambert France 
Published: January 2022

BackgroundPeriodontitis is a chronic inflammatory gum disease associated with systemic diseases such as cardiovascular diseases.AimTo investigate the association of systemic blood biomarkers, C-reactive protein (CRP), levels of lipopolysaccharide (LPS), and IgG levels against periodontal pathogens Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) with the stability, based on the aortic diameter, the growth rate and the eligibility for surgical intervention, of patients with abdominal aortic aneurysm (AAA).MethodsPatients with stable AAA (n = 30) and unstable AAA (n = 31) were recruited. The anti-A. actinomycetemcomitans and anti-P. gingivalis IgG levels were analyzed by ELISA, the LPS analysis was performed by using the limulus amebocyte lysate (LAL) test, and plasma levels of CRP were determined using an immune turbidimetric method. The association between these blood systemic biomarkers, AAA features, periodontal clinical parameters and oral microbial profiles were explored. Regression models were used to test the relationship between variables.ResultsThe presence of antibodies against Pg and Aa, LPS and high CRP concentrations were found in all AAA patients. The IgG levels were similar in patients with stable and unstable AAA (both for Aa and Pg). Among investigated blood biomarkers, only CRP was associated with AAA stability. The amount of LPS in saliva, supra, and subgingival plaque were significantly associated with the systemic LPS (p &lt;0.05).ConclusionsThis post-hoc study emphasizes the presence of antibodies against Pg and Aa, LPS and high CRP concentrations in all AAA patients. The presence of Pg in saliva and subgingival plaque was significantly associated with the blood LPS levels. For further studies investigating periodontitis and systemic diseases, specific predictive blood biomarkers should be considered instead of the use of antibodies alone.
Determining the Recoverable Geothermal Resources Using a Numerical Thermo-Hydraulic Coupled Modeling in Geothermal Reservoirs
Authors: Fan Yifan , Zhang Shikuan , Huang Yonghui , Pang Zhonghe , Li Hongyan 
Published: January 2022

Recoverable geothermal resources are very important for geothermal development and utilization. Generally, the recovery factor is a measure of available geothermal resources in a geothermal field. However, it has been a pre-determined ratio in practice and sustainable utilization of geothermal resources was not considered in the previous calculation of recoverable resources. In this work, we have attempted to develop a method to calculate recoverable geothermal resources based on a numerical thermo-hydraulic coupled modeling of a geothermal reservoir under exploitation, with an assumption of sustainability. Taking a geothermal reservoir as an example, we demonstrate the effectiveness of the method. The recoverable geothermal resources are 6.85 × 1018 J assuming a lifetime of 100 years in a well doublet pattern for geothermal heating. We further discuss the influence of well spacing on the recoverable resources. It is found that 600 m is the optimal well spacing with maximum extracted energy that conforms to the limit of the pressure drop and no temperature drop in the production well. Under the uniform well distribution pattern for sustainable exploitation, the recovery factor is 26.2%, which is higher than the previous value of 15% when depending only on lithology. The proposed method for calculating the recoverable geothermal resources is instructive for making decisions for sustainable exploitation.
Oil Occurrence States in Shale Mixed Inorganic Matter Nanopores
Authors: Liang Shuang , Wang Jia-Ming , Liu Yi-Kun , Liu Bo , Sun Shuo , Shen An-Qi , Tao Fei-Yu 
Published: January 2022

In present paper, the mineral and fluid compositions of shale oil from the Songliao Basin are analyzed systematically using core samples, X-ray diffractometer (XRD), and gas chromatography (GC). The effects of shale mineral composition, pore size, temperature, and pressure on the mass density of the adsorbed layers are then studied utilizing molecular dynamics simulation. The results show that illite and quartz are predominant in the micro petrological components of the shale, and nC19 is the main carbon peak. The fluid consists primarily of n-alkane molecules, and nC19 is found to be representative of the shale oil composition. Moreover, the adsorbing effect of quartz-illite mixed wall is between that of a pure mineral wall (illite and quartz), indicating that the selection of a mixed wall is similar to the actual shale composition. If the pores are inorganic, the minimum pore size of only adsorption oil is smaller than the organic pores. The critical adsorption point of shale oil in inorganic pores is less than 3.2 nm. Furthermore, compared to pressure, the temperature has a more significant effect on fluid adsorption due to the correlation with the kinetic energy of alkane molecules. This research shows the oil occurrence status in inorganic matter nanopore with a mixed solid wall, and provides theoretical support for shale oil exploration.
Current Progress of Jatropha Curcas Commoditisation as Biodiesel Feedstock: A Comprehensive Review
Authors: Riayatsyah T. M. I. , Sebayang A. H. , Silitonga A. S. , Padli Y. , Fattah I. M. R. , Kusumo F. , Ong H. C. , Mahlia T. M. I. 
Published: January 2022

This article looks at the national and global actors, social networks, and narratives that have influencedJatropha’sworldwide acceptability as a biofuel crop.Jatropha Curcasis a genus of around 175 succulent shrubs and trees in theEuphorbiaceaefamily (some of which are deciduous, such asJatropha CurcasL.). It’s a drought-tolerant perennial that thrives in poor or marginal soil and produces a large amount of oil per hectare. It is easy to grow, has a fast growth rate, and can generate seeds for up to 50 years.Jatropha Curcashas been developed as a unique and promising tropical plant for augmenting renewable energy sources due to its various benefits. It is deserving of being recognised as the only competitor in terms of concrete and intangible environmental advantages.Jatropha Curcasis a low-cost biodiesel feedstock with good fuel properties and more oil than other species. It is a non-edible oilseed feedstock. Thus it will have no impact on food prices or the food vs fuel debate.Jatropha Curcasemits fewer pollutants than diesel and may be used in diesel engines with equivalent performance.Jatropha Curcasalso makes a substantial contribution to the betterment of rural life. The plant may also provide up to 40% oil yield per seed based on weight. This study looks at the features characteristics ofJatropha Curcasas biodiesel feedstock and performance, and emissions of internal combustion engine that operates on this biodiesel fuel.
A Comparative Study of Particulate Matter Between New Delhi, India and Riyadh, Saudi Arabia During the COVID-19 Lockdown Period
Authors: Singh Bhupendra Pratap , Eldesoky Gaber E. , Kumar Pramod , Chandra Prakash , Islam Md Ataul , Rahman Shakilur 
Published: January 2022

Novel Coronavirus disease (COVID-19), after being identified in late December 2019 in Wuhan city of China, spread very fast and has affected all the countries in the world. The impact of lockdowns on particulate matter during the lockdown period needs attention to explore the correlation between anthropogenic and natural emissions. The current study has demonstrated the changes in fine particulate matter PM2.5, PM10 and their effect on air quality during the lockdown. The air quality before the lockdown was low in New Delhi (India) and Riyadh (Saudi Arabia), among major cities worldwide. The air quality of India is influenced by dust and sand from the desert and surrounding areas. Thus, the current study becomes important to analyse changes in the air quality of the Indian sub-continent as impacted by dust storms from long distances. The result indicated a significant reduction of PM2.5 and PM10 from 93.24 to 37.89 μg/m3 and from 176.55 to 98.87 μg/m3 during the lockdown period as compared to pre lockdown period, respectively. The study shows that average concentrations of PM10 and PM2.5 have declined by -44% and -59% during the lockdown period in Delhi. The average value of median PM10 was calculated at 33.71 μg/m3 for Riyadh, which was lower than that value for New Delhi during the same period. The values of PM10 were different for pre and during the lockdown periods in Riyadh, indicating the considerable influence on air quality, especially the concentration of PM10, from both the natural (sand and dust storms) and the anthropogenic sources during the lockdown periods. However, relatively smaller gains in the improvement of air quality in Riyadh were correlated to the imposition of milder lockdown and the predominance of natural factors over the anthropogenic factors there. The Air Quality Index (AQI) data for Delhi showed the air quality to be ‘satisfactory’ and in the green category during the lockdown period. This study attempts to better understand the impact of particulate matter on the short- and long-term air quality in Delhi during the lockdown. This study has the scope of being scaled up nationwide, and this might be helpful in formulation air pollution reduction and sustainable management policies in the future.
Establishment and Validation of a Ferroptosis-Related Gene Signature to Predict Overall Survival in Lung Adenocarcinoma
Authors: Wang Su , Xie Zhen , Wu Zenghong 
Published: January 2022

Background: Lung adenocarcinoma (LUAD) is the most common and lethal subtype of lung cancer. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a target in cancer therapy. However, the prognostic value of ferroptosis-related genes (FRGs)x in LUAD remains to be explored.Methods: In this study, we used RNA sequencing data and relevant clinical data from The Cancer Genome Atlas (TCGA) dataset and Gene Expression Omnibus (GEO) dataset to construct and validate a prognostic FRG signature for overall survival (OS) in LUAD patients and defined potential biomarkers for ferroptosis-related tumor therapy.Results: A total of 86 differentially expressed FRGs were identified from LUAD tumor tissues versus normal tissues, of which 15 FRGs were significantly associated with OS in the survival analysis. Through the LASSO Cox regression analysis, a prognostic signature including 11 FRGs was established to predict OS in the TCGA tumor cohort. Based on the median value of risk scores calculated according to the signature, patients were divided into high-risk and low-risk groups. Kaplan–Meier analysis indicated that the high-risk group had a poorer OS than the low-risk group. The area under the curve of this signature was 0.74 in the TCGA tumor set, showing good discrimination. In the GEO validation set, the prognostic signature also had good predictive performance. Functional enrichment analysis showed that some immune-associated gene sets were significantly differently enriched in two risk groups.Conclusion: Our study unearthed a novel ferroptosis-related gene signature for predicting the prognosis of LUAD, and the signature may provide useful prognostic biomarkers and potential treatment targets.
Tumor Flare Reaction in a Classic Hodgkin Lymphoma Patient Treated With Brentuximab Vedotin and Tislelizumab: A Case Report
Authors: Zhu Chunting , Zhao Yi , Yu Fang , Huang Weijia , Wu Wenjun , He Jingsong , Cai Zhen , He Donghua 
Published: January 2022

BackgroundTumor flare reaction (TFR) is a clinical syndrome, which is mainly associated with painful and swollen lymph nodes or splenomegaly, slight fever, bone pain, and skin rash during treatment with immune-related drugs, causing difficulty in distinguishing TFR from disease progression. Brentuximab vedotin (BV) and programmed death 1 (PD-1) inhibitor are two ideal drugs used for the treatment of classic Hodgkin lymphoma, but few studies have reported their adverse effects in association with TFR. The efficacy and safety of monotherapy or combination therapy with these drugs needs to be further evaluated. It is essential to determine whether treated patients can develop TFR, thus enabling more accurate diagnosis and treatment.Case presentationA 26-year-old female patient, diagnosed with classic Hodgkin lymphoma, had received 2 + 3 cycles of ABVD chemotherapy (a combination of adriamycin, bleomycin, vinblastine, and dacarbazine) and 4 cycles of PD-1 inhibitor (tislelizumab) therapy but exhibited poor efficacy. Subsequently, she was given combination therapy of BV (100 mg) + tislelizumab (200 mg). However, a slight fever, painful and swollen axillary lymph nodes, multiple skin rashes with pruritus, joint pain, and fatigue with poor appetite appeared during the treatment. Ultrasound (US) scans revealed that multiple lymph nodes were significantly enlarged. After treatment with low-dose dexamethasone and cetirizine, the symptoms were alleviated. A biopsy of the left axillary lymph node revealed that lymphoid tissue exhibited proliferative changes, without tumor cell infiltration. These findings were consistent with the clinical and pathological manifestations of TFR.ConclusionCombination therapy with BV and PD-1 inhibitor was effective in the treatment of relapsed or refractory classic Hodgkin lymphoma. The results suggest that the combination therapy may cause TFR, and biopsy and also continuous imaging observation are important to determine the disease stage. This approach allows clinicians to decide whether to continue the current treatment plan, and alerts them to the occurrence of excessive activation of the immune system.