bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral Autoregulation Correlation With Outcomes and Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage
Authors: Owen Bryce , Vangala Adarsh , Fritch Chanju , Alsarah Ali A. , Jones Tom , Davis Herbert , Shuttleworth C. William , Carlson Andrew P. 
Published: February 2022

Background:
Delayed cerebral ischemia remains one of the principal therapeutic targets after aneurysmal subarachnoid hemorrhage. While large vessel vasospasm may contribute to ischemia, increasing evidence suggests that physiological impairment through disrupted impaired cerebral autoregulation (CA) and spreading depolarizations (SDs) also contribute to delayed cerebral ischemia and poor neurological outcome. This study seeks to explore the intermeasure correlation of different measures of CA, as well as correlation with SD and neurological outcome.

Methods:
Simultaneous measurement of 7 continuous indices of CA was calculated in 19 subjects entered in a prospective study of SD in aneurysmal subarachnoid hemorrhage undergoing surgical aneurysm clipping. Intermeasure agreement was assessed, and the association of each index with modified Rankin Scale score at 90 days and occurrence of SD was assessed.

Results:
There were 4102 hours of total monitoring time across the 19 subjects. In time-resolved assessment, no CA measures demonstrated significant correlation; however, most demonstrate significant correlation averaged over 1 hour. Pressure reactivity (PRx), oxygen reactivity, and oxygen saturation reactivity were significantly correlated with modified Rankin Scale score at 90 days. PRx and oxygen reactivity also were correlated with the occurrence of SD events. Across multiple CA measure reactivity indices, a threshold between 0.3 and 0.5 was most associated with intervals containing SD.

Conclusions:
Different continuous CA indices do not correlate well with each other on a highly time-resolved basis, so should not be viewed as interchangeable. PRx and oxygen reactivity are the most reliable indices in identifying risk of worse outcome in patients with aneurysmal subarachnoid hemorrhage undergoing surgical treatment. SD occurrence is correlated with impaired CA across multiple CA measurement techniques and may represent the pathological mechanism of delayed cerebral ischemia in patients with impaired CA. Optimization of CA in patients with aneurysmal subarachnoid hemorrhage may lead to decreased incidence of SD and improved neurological outcomes. Future studies are needed to evaluate these hypotheses and approaches.
Continental Water Vapor Dominantly Impacts Precipitation during the Snow Season on the Northeastern Tibetan Plateau
Authors: Wang Weiguo , Li Hongyi , Xie Zeming , Zhu Xiaofan , Xiao Linhong , Hao Xiaohua , Wang Jian 
Published: February 2022

AbstractAtmospheric water vapor plays a key role in the water cycle, especially on the Tibetan Plateau, where precipitation is an invaluable contributor to water resources. To better understand which water vapor source areas influence precipitation on the northeastern Tibetan Plateau (NETP), we applied the flexible particle dispersion method (FLEXPART) to simulate water vapor trajectories and water vapor source contribution related to precipitation events during the snow season from 1979 to 2017 on the NETP. The results show that continental water vapor source areas contributed 92.33% of the water vapor to precipitation events on the NETP, which was obviously greater than the water vapor contribution from oceanic areas. One key continental water vapor source area, the Tibetan Plateau without the study area, contributed 66.13% of the water vapor to the precipitation, and central Asia supplied 8.69%, ranking second. Comparing the distributions of the water vapor contributions to extensive and regional precipitation events revealed that the only difference between extensive and regional precipitation events is in the magnitudes of the water vapor contributions, and the spatial distributions of the water vapor contributions are extremely similar. Central and southern China obviously supplied more water vapor to extensive precipitation events than to regional precipitation events. These results help us better understand the recent drastic precipitation changes on the NETP.Significance StatementWe sought to understand how water vapor influences precipitation over the northeastern Tibetan Plateau and which water vapor source areas play a key role in the water vapor supply. Therefore, we applied a numerical model to investigate the relationship between water vapor and precipitation from 1979 to 2017 during the snow season. Continental water vapor source areas contributed considerably more water vapor than oceanic water vapor source areas. The most important continental water vapor contributor was the Tibetan Plateau without the northeastern Tibetan Plateau area, and the second highest contributor was central Asia. Future work should focus on how water vapor impacts the precipitation changes in this wetter and warming area.
Disasters, Displacement, and Housing Instability: Estimating Time to Stable Housing 13 Years after Hurricane Katrina
Authors: Merdjanoff Alexis A. , Abramson David M. , Park Yoon Soon , Piltch-Loeb Rachael 
Published: February 2022

Abstract
Catastrophic disasters disrupt the structural and social aspects of housing, which can lead to varying lengths of displacement and housing instability for affected residents. Stable housing is a critical aspect of postdisaster recovery, which makes it important to understand how much time passes before displaced residents are able to find stable housing. Using the Gulf Coast Child and Family Health Study, a longitudinal cohort of Mississippi and Louisiana residents exposed to Hurricane Katrina (n = 1079), we describe patterns of stable housing by identifying protective and prohibitive factors that affect time to stable housing in the 13 years following the storm. Survival analyses reveal that median time to stable housing was 1082 days—over 3 years after Katrina. Age, housing tenure, marital status, income, and social support each independently affected time to stable housing. Findings suggest that postdisaster housing instability is similar to other forms of housing instability, including eviction, frequent moves, and homelessness.

Significance Statement
Climate change is expected to increase gradual-onset events like sea level rise, as well as the frequency and intensity of acute disasters like hurricanes. Such events when coupled with population growth, coastline development, and increasing inequality will lead to high levels of displacement and housing instability. Using longitudinal data, we wanted to understand how much time passed until residents who were displaced by Hurricane Katrina were able to find permanent and stable housing and identify factors that either prolonged or accelerated respondents’ time to stable housing. Addressing this gap can help to improve resident recovery and create targeted postdisaster housing policy, especially as displacement from disasters becomes increasingly common among those living in regions susceptible to the effects of climate change.
Incidence of treated first-episode psychosis amongst Aboriginal and non-Aboriginal youth in the Top End of the Northern Territory, Australia
Authors: Mirza Tamoor , Taft William , He Vincent Yaofeng , Gooding Jade , Dingwall Kylie , Nagel Tricia 
Published: February 2022

Objectives This study aims to estimate the incidence rate of first episode of psychosis (FEP) in the Top End of the Northern Territory (NT), exploring how rates vary by age, sex, Aboriginal status and remoteness. Method Youths (ages 15–24) presenting with FEP to the two specialist mental health services in the Top End were identified through audit of the electronic health records between 2014–2018. Population demographic data were collected from the 2016 Australian National Census. Statistical analysis estimated variation in incidence rates by age, sex, Aboriginal status and remoteness. Results A total of 236 youths with FEP were included in the study. The overall incidence rate was 174 per 100,000 person-years. Rates were very high in the Aboriginal (331 per 100,000 person-years) and remote populations (308 per 100,000 person-years), and lower in the non-Aboriginal population (85 per 100,000 person-years). Conclusion This study shows high rates of FEP in young people in the Top End, attributable to very high rates in the Aboriginal population, many of whom live in remote areas. Resources should be allocated to support this high-risk group.
Current Surgical Practice for Children Born with a Cleft lip and/or Palate in the United Kingdom
Authors: Fell Matthew , Davies Alex , Davies Amy , Chummun Shaheel , Cobb Alistair R.M. , Moar Kanwalraj , Wren Yvonne 
Published: February 2022

Objective This study describes primary surgical reconstructions performed for children born with a cleft lip and/or palate (CL ± P) in the United Kingdom (UK). Design Data forms completed at the time of surgery included details on timing, technique, and adjuncts used during the operative period. Demographic data on participants were validated via parental questionnaires. Setting Data were obtained from the Cleft Collective, a national longitudinal cohort study. Patients Between 2015 and 2021, 1782 Cleft Collective surgical forms were included, relating to the primary reconstructions of 1514 individual children. Results The median age at primary cheiloplasty was 4.3 months. Unilateral cleft lips (UCL) were reconstructed with an anatomical subunit approximation technique in 53%, whereas bilateral cleft lips (BCL) were reconstructed with a broader range of eponymous techniques. Clefts of the soft palate were reconstructed at a median age of 10.3 months with an intravelar veloplasty in 94% cases. Clefts of the hard palate were reconstructed with a vomer flap in 84% cases in a bimodal age distribution, relating to reconstruction carried out simultaneously with either lip or soft palate reconstruction. Antibiotics were used in 96% of cases, with an at-induction-only regimen used more commonly for cheiloplasties ( P < .001) and a 5 to 7-day postoperative regime used more commonly for soft palatoplasties ( P < .001). Perioperative steroids were used more commonly in palatoplasties than cheiloplasties ( P < .001) but tranexamic acid use was equivalent ( P = .73). Conclusions This study contributes to our understanding of current cleft surgical pathways in the UK and will provide a baseline for analysis of the effectiveness of utilized protocols.
Maternal near-miss and mortality in a teaching hospital in Tigray region, Northern Ethiopia
Authors: Teka Hale , Yemane Awol , Berhe Zelelow Yibrah , Tadesse Habtom , Hagos Hadgay 
Published: February 2022

Objective: This study seeks to examine the prevalence of maternal morbidities and deaths in Ayder Comprehensive Specialized Hospital from 1 July 2018 to 30 June 2019. Methods: This was a cross-sectional study. Total purposive sampling method was employed to collect data prospectively using modified World Health Organization criteria for baseline assessment of maternal near-miss and mortality. Pregnant women or those who are within 42 days postpartum/any form of pregnancy termination that satisfy the inclusion criteria were enrolled. Results: A total of 691 mothers were recorded as having severe maternal complications. Out of these, 170 women developed severe maternal outcome, ending with 146 maternal near-miss cases and 24 maternal deaths. The maternal near-miss ratio and maternal mortality ratio were 28.5 per 1000 live births and 469.1 per 100,000 live births, respectively. The overall mortality index was 14%. The top underlying causes of severe maternal complications were the infamous triads of preeclampsia (n = 303, 43.8%), obstetric hemorrhage (n = 166, 24.0%) and sepsis (n = 130, 18.8%). About 62.5% of mothers who died were not admitted to intensive care unit. Conclusion: This study found that the infamous triads of preeclampsia, obstetric hemorrhage and sepsis persist as the commonest causes of severe maternal complications in the study area. A significant number of women with severe maternal outcome were not admitted to intensive care unit. It also highlights that the severe maternal complications, severe maternal outcome, maternal near-miss ratio and mortality index in the study area are disproportionately higher than the global average. These staggering numbers call for a system re-thinking at multiple junctures.
Genistein protects against ultraviolet B–induced wrinkling and photoinflammation in in vitro and in vivo models
Authors: Tang Sheau-Chung , Hsiao Yu-Ping , Ko Jiunn-Liang 
Published: February 2022

Abstract
Background
Chronic exposure to ultraviolet (UV) rays causes severe skin damage by inducing oxidative stress and inflammation. Identifying a safe and natural substance for skin protection is a crucial research goal.

Objective
The aim of this study was to clarify the effects of genistein on skin inflammation and photoaging by using 3 models (humans: skin parameters; animals: wrinkle formation; and cells: anti-inflammatory effects).

Methods
Food frequency questionnaire data and serum and skin parameter data from 120 volunteers (a group with a genistein-rich diet [RG group] and a control group). Human keratinocytes were pretreated with genistein before ultraviolet B (UVB) irradiation. Genistein was topically applied to the dorsal skin of rats.

Results
The blood samples of the RG group had lower serum uric acid levels and blood urea nitrogen levels. The dynamic elasticity level in the RG group was higher than that in the controls. Genistein pretreatment suppressed the expression of proinflammatory cytokines (CXCL1, IL-1, MIF, and PLANH1) and the proteins released by UVB-treated keratinocytes. Topical application of genistein to the dorsal skin of rats reduced the severity of UVB-induced wrinkling. Both intake and topical application of genistein combated UVB-induced inflammation and aging.

Conclusions
Genistein could be used as a safe and natural compound for use in novel anti-inflammatory agents for topical application.

Graphical abstract
The experimental design procedure, including the skin parameter and blood serum measurements of 137 participants. Genistein-rich compounds provide protection against UVB-induced inflammation, as determined using in vitro and in vivo animal model experiments.
Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma
Authors: Mizutani Yasuyuki , Iida Tadashi , Ohno Eizaburo , Ishikawa Takuya , Kinoshita Fumie , Kuwatsuka Yachiyo , Imai Miwa , Shimizu Shinobu , Tsuruta Toshihisa , Enomoto Atsushi , Kawashima Hiroki , Fujishiro Mitsuhiro 
Published: February 2022

Abstract
Background
Cancer-associated fibroblasts (CAFs) are an important component of the tumour microenvironment. Recent studies revealed CAFs are heterogeneous and CAF subset(s) that suppress cancer progression (cancer-restraining CAFs [rCAFs]) must exist in addition to well-characterised cancer-promoting CAFs (pCAFs). However, the identity and specific markers of rCAFs are not yet reported. We recently identified Meflin as a specific marker of rCAFs in pancreatic and colon cancers. Our studies revealed that rCAFs may represent proliferating resident fibroblasts. Interestingly, a lineage tracing experiment showed Meflin-positive rCAFs differentiate into α-smooth muscle actin-positive and Meflin-negative CAFs, which are generally hypothesised as pCAFs, during cancer progression. Using a pharmacological approach, we identified AM80, a synthetic unnatural retinoid, as a reagent that effectively converts Meflin-negative pCAFs to Meflin-positive rCAFs. We aimed to investigate the efficacy of a combination of AM80 and gemcitabine (GEM) and nab-paclitaxel (nab-PTX) in patients with advanced pancreatic cancer.

Methods
The phase I part is a 3 + 3 design, open-label, and dose-finding study. The dose-limiting toxicity (DLT) of these combination therapies would be evaluated for 4 weeks. After the DLT evaluation period, if no disease progression is noted based on the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 or if the patient has no intolerable toxicity, administration of AM80 with GEM and nab-PTX would be continued for up to 24 weeks. The phase II part is an open-label, single-arm study. The maximum tolerated dose (MTD) of AM80 with GEM and nab-PTX, determined in phase I, would be administered until intolerable toxicity or disease progression occurs, up to a maximum of 24 weeks, to confirm efficacy and safety.
The primary endpoints are frequency of DLT and MTD of AM80 with GEM and nab-PTX in the phase I part and response rate based on the RECIST in the phase II part. Given the historical control data, we hope that the response rate will be over 23% in phase II.

Discussion
Strategies to convert pCAFs into rCAFs have been developed in recent years. We hypothesised that AM80 would be a promising enhancer of chemosensitivity and drug distribution through CAF conversion in the stroma.

Trial registration
Clinicaltrial.gov: NCT05064618, registered on 1 October 2021.
jRCT: jRCT2041210056, registered on 27 August 2021.
Melatonin for pre-medication in children: a systematic review
Authors: Mellor Katie , Papaioannou Diana , Thomason Anna , Bolt Robert , Evans Chris , Wilson Matthew , Deery Chris 
Published: February 2022

Abstract
Background
Melatonin’s effectiveness as an anxiolytic medication has been confirmed in adults; however, its efficacy in a paediatric population is unclear. A number of small studies have assessed its use in children as a pre-operative anxiolytic, with conflicting results.

Methods
We undertook a systematic review of pre-operative melatonin use in children. Four databases (MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Web of Science), and ‘ClinicalTrials.gov’ were searched for ongoing and completed clinical trials of relevance. Citation tracking reference lists and relevant articles were also accessed. The review was unrestricted by comparator or outcomes. Eleven studies were judged eligible for inclusion. There were high levels of heterogeneity in melatonin administration (in terms of dose and timing). Variable outcomes were reported and included: anxiety; anaesthetic success; analgesia; sedation; post-operative recovery; and safety. Outcomes were not always assessed with the same measures.

Results
Evidence to support melatonin’s anxiolytic properties in this setting is conflicting. Melatonin was associated with reduced sedative effects, post-operative excitement and improved emergence behaviour, compared to comparator drugs. One study reported the benefit of melatonin use on sleep disturbance at two weeks post-surgery. No adverse safety events were identified to be significantly associated with melatonin, affirming its excellent safety profile.

Conclusion
Despite potential advantages, including improved emergence behaviour, based on current evidence we cannot confirm whether melatonin is non-inferior to current “usual care” pre-medications. Further consideration of melatonin as an anxiolytic pre-medication in paediatric surgery is needed.
Stress eating: an online survey of eating behaviours, comfort foods, and healthy food substitutes in German adults
Authors: Gemesi Kathrin , Holzmann Sophie Laura , Kaiser Birgit , Wintergerst Monika , Lurz Martin , Groh Georg , Böhm Markus , Krcmar Helmut , Gedrich Kurt , Hauner Hans , Holzapfel Christina 
Published: February 2022

Abstract
Background
In many people, stress is associated with changes in eating behaviour. Food products consumed during stress (comfort foods) are often unhealthy. It is rather unknown what comfort foods are consumed in Germany and what healthier food products are considered as alternatives to support stress-eaters in making healthier food choices.

Methods
This online survey was conducted in spring 2021 throughout Germany. Participants were digitally recruited by newsletters, homepages, social media, and mailing lists. The survey included a standardized questionnaire with items concerning e.g. sociodemography, stress, and nutrition. Comfort foods were pre-selected through literature search and food substitutes were defined and discussed by experts. Analyses examined comfort food consumption and substitute preferences dependent on sex, age, body mass index (BMI), and being a self-identified stress-eater. The statistical analysis was performed using R.

Results
Survey participants were mostly female (80.6%, 994/1234), had a mean age of 31.4 ± 12.8 years and a mean BMI of 23.4 ± 4.3 kg/m2. Participants stated, that the two favourite comfort foods were chocolate (consumed often/very often by 48.3%, 596/1234) and coffee (consumed often/very often by 45.9%, 566/1234). Regarding food substitutes, the most frequently named alternative food for chocolate and cookies was fresh fruits (for chocolate: 74.4%, 815/1096, for cookies: 62.6%, 565/902). Tea without added sugar (64.4%, 541/840) was the preferred substitute for coffee. Almost 50% of participants (48.1%, 594/1234) identified themselves as stress-eaters, of which 68.9% (408/592) stated to eat (very) often more than usual in subjective stress situations.

Conclusions
The results from this work suggest that specific comfort foods and substitutes are preferred by the participants in stressful situations. This knowledge about food choices and substitutes should be investigated in further studies to improve eating behaviour in stressful situations.

Trial registration
The survey was registered in the German Register of Clinical Studies (Registration number: DRKS00023984).
Evaluation of ‘Shisha No Thanks’ – a co-design social marketing campaign on the harms of waterpipe smoking
Authors: Chan Lilian , El-Haddad Nouhad , Freeman Becky , MacKenzie Ross , Woodland Lisa , O’Hara Blythe J. , Harris-Roxas Ben F. 
Published: February 2022

AbstractBackgroundWaterpipe (shisha) is becoming increasingly popular worldwide, particularly among young people; and in some countries, it is one of the few forms of tobacco use that is increasing. While there is a growing body of evidence of the harms of waterpipe smoke, there is a scarcity of research of interventions to address this form of tobacco consumption.MethodsTheShisha No Thanksproject was a co-design social marketing campaign that aimed to raise awareness of the harms of waterpipe smoking among young people from an Arabic speaking background in Sydney, Australia. The campaign distributed material through social media and community events. We evaluated the project through an SMS community panel using a longitudinal study design. The cohort were sent questions before and after the project asking about their awareness of messages of harms, attitudes, intention to reduce waterpipe smoking, and awareness of support services. Data was analysed as matched pre- post- data.ResultsThe evaluation recruited 133 people to the panel. There was a significantly greater proportion of people who reported seeing, hearing or reading something about the harms of waterpipe smoking after the campaign (67.5%) compared with before (45.0%) (p=0.003). Post-campaign, there were higher proportions of people who strongly agreed that waterpipe smoking causes damage, and that it contains cancer-causing substances, but these increases were not statistically significant. There was low awareness of waterpipe cessation services at baseline and post campaign (22.5%).ConclusionsTheShisha No Thanksproject increased awareness of messages about the harms of waterpipe smoking. Although this is a small study, the longitudinal evaluation findings have international relevance and make a useful contribution to the understanding of the impact such interventions can have in addressing one of the few forms of tobacco use that is growing in both developed and developing countries.