bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of robot‐assisted nipple‐sparing mastectomy using the da Vinci SP system
Authors: Go Jieon , Ahn Jee Hyun , Park Jung Min , Choi Soon Bo , Lee Jeea , Kim Jee Ye , Park Hyung Seok 
Published: May 2022

AbstractBackgroundAs patients tend to be diagnosed with breast cancer at an early stage, the demand for better cosmetic outcomes has increased. Several studies revealed that robot‐assisted nipple‐sparing mastectomy (RNSM) shows favorable outcomes. The aim of the study was to reveal the feasibility of RNSM using the da Vinci single‐port (SP) system with a minimal incision, hidden in the arm.MethodsFrom 2018 to 2021, 81 cases (70 patients) were retrospectively reviewed. Clinicopathologic characteristics, operative outcomes, and postoperative complications were evaluated. The operative outcomes were analyzed using the Mann–Whitney U test.ResultsThe median age was 42 years (range, 26–60 years). Bilateral RNSM was performed in 11 (27.2%) patients. The median size of the initial skin incision was 40 mm (range, 20–55 mm). Immediate reconstruction with direct‐to‐implant was performed in 54 (66.7%) patients and deep inferior epigastric perforator (DIEP) flaps in 15 (18.5%) patients. Postoperative complications of Clavien–Dindo Classification III occurred in six (7.5%) patients. Patients reconstructed with a DIEP flap had large breasts with more severe ptosis, yet grade III complications did not occur.ConclusionsRNSM using the SP system can be applied for curative and risk‐reducing mastectomy, regardless of breast size or ptosis grade.
Lack of Association Between a Quantified Lung Ultrasound Score and Illness Severity in Pediatric Emergency Department Patients With Acute Lower Respiratory Infections
Authors: Kessler David , Dessie Almaz , Kanjanauptom Panida , Vindas Marc , Ng Lorraine , Youssef Mariam M. , Birger Ruthie , Shaman Jeff , Dayan Peter 
Published: May 2022

ObjectivesLung ultrasound (LUS) may help determine illness severity in children with acute lower respiratory tract infections (LRTI) but limited pediatric studies exist. Our objective was to determine the association between LUS findings and illness severity in children with LRTI.MethodsWe conducted a prospective study of patients <20 years with LRTI. Trained investigators performed standardized LUS examinations of 12 regions. Blinded sonologists reviewed examinations for individual pathologic features and also calculated a Quantified Lung Ultrasound Score (QLUS). We defined focal severity as QLUS of ≥2 in ≥1 region, and diffuse severity as QLUS of ≥1 in ≥3 regions. The primary outcome was the Respiratory component of the Pediatric Early Warning Score (RPEWS), a 14‐item scale measuring respiratory illness severity. Secondary outcomes included hospital admission, length of stay, supplemental oxygen, and antibiotic use.ResultsWe enrolled 85 patients with LRTIs, 46 (54%) whom were hospitalized (5.4% intensive care). Median RPEWS was 1 (interquartile range 2). Neither individual features on ultrasound nor total QLUS were associated with RPEWS, hospitalization, length of stay, or oxygen use. Mean RPEWS was similar for participants regardless of focal (1.46 versus 1.26, P = .57) or diffuse (1.47 versus 1.21, P = .47) severity findings, but those with focal or diffuse severity, or isolated consolidation, had greater antibiotic administration (P < .001).ConclusionsIn children with LRTI, neither individual features nor QLUS were associated with illness severity. Antibiotics were more likely in patients with either focal or diffuse severity or presence of consolidation on ultrasound.
A novel MPZL2 c.68delC variant is associated with progressive hearing loss in Chinese population and literature review
Authors: Wang Zhili , Jiang Mengda , Wu Hao , Li Yun , Chen Ying 
Published: May 2022

AbstractObjectiveThe aim of this study was to identify genetic etiology in two unrelated Chinese probands with progressive sensorineural hearing loss.MethodsTwo unrelated Chinese families were recruited. Genetic etiology was identified by targeted next‐generation sequencing (NGS) and verified by Sanger sequencing. Hearing evaluations included pure tone audiometry, auditory brainstem response to clicks, and otoscopic examination. Medical history and computerized tomography scan of temporal bone were also collected. In addition, linear regression was used to summarize all of the reported cases and estimate the progression of hearing loss.ResultsA 28‐year‐old man with variant c.68delC had progressive, moderately severe hearing loss and a suspicious history of renal impairment. His hearing result was 63.75 dB HL. The other proband was the youngest patient with MPZL2‐related hearing loss reported so far in the literature (genotype: c.220C>T homozygote). Her hearing result by click‐ABR was 25 dB nHL at 3 months of age, and deteriorated to 40 dB nHL at 15 months. Behavioral audiometry identified a hearing loss of 26.25 dB HL. In summarizing all of the reported cases, using linear regression, MPZL2‐related hearing loss may deteriorate by 0.59 dB HL per year, and different MPZL2 variants may lead to different rates of progression.ConclusionIn this study, we first identified two unrelated patients with MPZL2‐related hearing loss in Chinese population, and a novel variant c.68delC. Our results expanded the mutation spectrum of deafness genes. Further studies are required to clarify the genotype–phenotype correlation and the progression of MPZL2‐related hearing loss.
Non‐Covalent Cross‐Linking Does the Job: Why PIM‐1/Silicalite‐1 Mixed Matrix Membranes Perform Well Notwithstanding Silicalite‐1
Authors: Santaniello Anna , Golemme Giovanni 
Published: May 2022

AbstractThe macroscopic modeling of gas transport in mixed‐matrix membranes (MMMs) made of a Polymer of Intrinsic Microporosity (PIM‐1) and silicalite1 (MFI) is compared to the experimental results presented in a previous paper, which shows unexpectedly large gas separation factors, although the silicalite‐1 filler is practically nonselective. The mismatch between the predictions of the Maxwell model and the experiments is zeroed by the recognition of nonideal effects, the extent of which is evaluated. The good performance of the PIM‐1 MMM is explained by non‐covalent cross‐linking of the PIM‐1 matrix. Cross‐linking results from π−π stacking interactions between the 2‐phenylethyl grafts on the outer surface of the MFI crystals and the aromatic ladder segments of PIM‐1, in agreement with the current explanation of the good transport performance of PIM‐1 MMMs containing porous aromatic fillers (e.g., PAF‐1).
Benefits and Risks of a Staged‐Bilateral VIM Versus Unilateral VIM DBS for Essential Tremor
Authors: Prakash Prarthana , Deuschl Guenther , Ozinga Sarah , Mitchell Kyle T. , Cheeran Binith , Larson Paul S. , Merola Aristide , Groppa Sergiu , Tomlinson Tucker , Ostrem Jill L. 
Published: May 2022

ABSTRACTBackgroundDespite over 30 years of clinical experience, high‐quality studies on the efficacy of bilateral versus unilateral deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus for medically refractory essential tremor (ET) remain limited.ObjectivesTo compare benefits and risks of bilateral versus unilateral VIM DBS using the largest ET DBS clinical trial dataset available to date.MethodsParticipants from the US St. Jude/Abbott pivotal ET DBS trial who underwent staged‐bilateral VIM implantation constituted the primary cohort in this sub‐analysis. Their assessments “on” DBS at six months after second‐side VIM DBS implantation were compared to the assessments six months after unilateral implantation. Two control cohorts of participants with unilateral implantation only were also used for between‐group comparisons.ResultsThe primary cohort consisted of n = 38 ET patients (22M/16F; age of 65.3 ± 9.5 years). The second side VIM‐DBS resulted in a 29.6% additional improvement in the total motor CRST score (P < 0.001), with a 64.1% CRST improvement in the contralateral side (P < 0.001). An added improvement was observed in the axial tremor score (21.4%, P = 0.005), and CRST part B (24.8%, P < 0.001) score. Rate of adverse events was slightly higher after bilateral stimulation.ConclusionsIn the largest ET DBS study to date, staged‐bilateral VIM DBS was a highly effective treatment for ET with bilateral implantation resulting in greater reduction in total motor tremor scores when compared to unilateral stimulation alone.
Hereditary hemorrhagic telangiectasia: First demonstration of a founder effect in Italy; the ACVRL1 c.289_294del variant originated in the country of Bergamo 200 years ago
Authors: Sbalchiero Anna , Abu Hweij Yasmin , Mazza Tommaso , Buscarini Elisabetta , Scotti Claudia , Pagella Fabio , Manfredi Guido , Matti Elina , Spinozzi Giuseppe , Olivieri Carla 
Published: May 2022

AbstractBackgroundHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder, affecting 1:5000 individuals worldwide. All the genes associated to the disease (ENG, ACVRL1, SMAD4, GDF2) belong to the TGF‐β/BMPs signaling pathway.We found 19 HHT unrelated families, coming from a Northern Italy region and sharing the ACVRL1 in‐frame deletion c.289_294del (p.H97_N98).MethodsTo test the hypothesis of a founder effect, we analyzed 88 subjects from 19 families (66 variant carriers, showing clinical signs of HHT, and 22 non‐carriers, unaffected) using eight microsatellite markers within 3.7 Mb around the ACVRL1 locus. After the haplotype reconstruction, age estimation of the variant was carried out.ResultsWe observed a common disease haplotype in 16/19 families, while three families showed evidence of recombination around the ACVRL1 locus. The subsequent age estimation analyses suggested that the mutation occurred about 8 generations ago, corresponding to about 200 years ago. We also present novel in silico and modeling data supporting the variant pathogenicity: the deletion alters the protein stability and removes the unique extracellular glycosylation site.ConclusionWe have demonstrated, for the first time, a “founder effect” for a HHT pathogenic variant in Italy.
Axisymmetrical analytical solution to the transient heat transfer problem in geological media
Authors: Cheng Xiaohui , Lu Xiaoyu , Liu Ziqi 
Published: May 2022

AbstractLaplace transforms were used in this paper to obtain analytical solutions for the axisymmetric problem under a constant well temperature using the convective heat transfer boundary condition, which included the conduction and convection in the aquifer as well as heat exchange at the boundary. This solution curve intuitively illustrates the temperature distribution within the aquifer. The effects of various parameters on this analytical solution were analyzed. According to this parametric analysis there exists a quasi‐steady‐state of temperature distribution in the axisymmetrical situation, which is different from the planar symmetry problem. In addition, the thermal breakthrough increases with the injected rate and decreases with the increasing convective heat transfer coefficient. Our analytical solution matched the results yielded by the numerical simulation quite well.
Internalized weight stigma in women with class III obesity: A randomized controlled trial of a virtual lifestyle modification intervention followed by a mindful self‐compassion intervention
Authors: Braun Tosca D. , Olson Kayloni , Panza Emily , Lillis Jason , Schumacher Leah , Abrantes Ana M. , Kunicki Zachary , Unick Jessica L. 
Published: May 2022

AbstractBackgroundInternalized weight stigma (Internalized‐WS) is prevalent among individuals with severe obesity, particularly women, and is associated with shame, disordered eating, and weight gain. Effective, accessible interventions that address both severe (Class‐III) obesity and Internalized‐WS are needed. This randomized pilot trial evaluated the feasibility, acceptability, and preliminary efficacy of a fully‐remote lifestyle modification intervention (LM) followed by mindful self‐compassion training (MSC) or control.MethodsTwenty‐eight women with Class‐III obesity (46.6 ± 3.7 kg/m2) and elevated Internalized‐WS were randomized to a virtually‐delivered 4‐month LM followed by a 2‐month MSC or cooking/dietary education (CON). Psychosocial measures/weight were assessed at baseline, 4‐(post‐LM), 6‐(post‐MSC/CON), and 9‐month (follow‐up).ResultsImprovements in Internalized‐WS, shame, and self‐compassion were observed with LM. Mean 4‐month weight loss was 6.3 ± 3.7%. MSC had lower attendance and usefulness ratings versus CON. Post‐MSC/CON, MSC yielded significant and/or meaningful improvements in Internalized‐WS, self‐compassion, and intuitive eating relative to CON. Weight loss did not differ by group at 6‐month, and at 9‐month trended lower in MSC versus CON.ConclusionVirtual LM is feasible, acceptable, and leads to significant weight loss among women with severe obesity; MSC led to further improved Internalized‐WS, self‐compassion, and intuitive eating. Continued work is needed to elucidate effects of self‐compassion training on Internalized‐WS, its mechanisms, and linkages to cardiometabolic health and long‐term weight loss.
Thermal analysis and tribo‐performance evaluation of multilayered graphene and graphite based fly ash filled banana fiber reinforced brake friction composites
Authors: Ahlawat Vishal , Tewatia Praveen , Nain Sunil , Kumar Raj , Kumar Sunil , Singh Tej 
Published: May 2022

AbstractThis study compared thermal and tribological properties of multilayered graphene‐based flyash filled and banana fiber reinforced brake friction composites with graphite‐based specimens. Two series of brake friction composites by varying the content of graphene/graphite (1, 2, and 3 wt%) were manufactured and tribo‐evaluated using a pin‐on‐disc type tribo‐tester. Tribological properties of the brake friction composites were studied at varying test conditions of normal load (50 and 150 N) and sliding velocity (3.3 and 9.9 m/s). Compared to graphene, the thermal stability remains higher for graphite lubricated composites and decreases with increased graphite/graphene loading. The developed graphite/graphene brake friction composites resulted in a reduction in friction coefficient with increasing sliding velocity and normal loads. The graphene‐filled composite exhibited higher friction performance with enhanced wear resistance at lower sliding velocity than graphite‐based composites. The friction performance of graphite‐filled composites and the graphene‐filled composite's wear resistance remains highest at higher sliding velocity conditions. Moreover, it is observed that the wear rate of graphene lubricated composites remains 21%–35% lowers than the graphite‐filled composite. Finally, the worn composite surfaces were analyzed using a scanning electron microscopy to study the possible wear mechanisms and to understand the nature of the formed contact patches/plateaus remain vital for deciding the tribological behavior of the composites.
Effects of different weaving patterns on thermomechanical and dynamic mechanical properties of Kevlar/pineapple leaf fiber hybrid composites
Authors: Jeyaguru Sangilimuthukumar , Thiagamani Senthil Muthu Kumar , Pulikkalparambil Harikrishnan , Siengchin Suchart , Krishnasamy Senthilkumar , Rajkumar Arpitha Gulihonenahali , Muthukumar Chandrasekar , Rangappa Sanjay Mavinkere 
Published: May 2022

AbstractIn the present study, different weaving patterns (plain, twill, and basket types) on intra‐ply Kevlar and pineapple leaf fiber (PALF) woven hybrid fabrics with epoxy matrix composites were fabricated using compression molding process and their thermomechanical and dynamic mechanical characteristics were examined. From the results, it was evident that pure Kevlar composites have the best flexural, impact, and interlaminar shear strength properties of all composites. However, the basket type weaving pattern on intra‐ply hybrid composites possesses better flexural strength of 282 MPa and flexural modulus of 6 GPa, the impact strength of 16.3 kJ/m2, interlaminar shear strength of 3.43 MPa. Moreover, it is observed that the pure Kevlar and twill type weaving patterns have better thermal stability compared to the remaining composites. The dynamic mechanical analysis results observed plain type intra‐ply hybrid composites possess enhanced storage modulus, loss modulus, and tan delta values due to their greater interfacial adhesion between Kevlar and PALF fiber with epoxy matrix. The differential scanning calorimetry results showed both basket weave and twill weave hybrid composites had the greatest glass transition temperature values of 78 and 76°C, respectively. Further, the thermomechanical analysis showed basket type hybrid composites have the lowest coefficient of thermal expansion and highest glass transition temperature value of 63.34°C. To conclude, these intra‐ply hybrid composites have enhanced mechanical strength and thermal stability, indicating suitable automotive interior parts applications.
Myocardial infarction associated with erenumab: A case report
Authors: Perino Justine , Corand Virginie , Laurent Elise , Théophile Hélène , Miremont‐Salamé Ghada , Pariente Antoine , Colas Jean‐Laurent , Couffinhal Thierry , Salvo Francesco 
Published: May 2022

AbstractBackgroundMonoclonal antibodies acting on the calcitonin gene‐related peptide or its receptor (CGRP‐mabs) are novel drugs for resistant migraine prophylaxis. As CGRP‐mabs cause inhibition of vasodilatation, their use is reserved to patients with no recent history of cardiovascular diseases. We report a case of myocardial infarction associated with erenumab.CaseA 57‐year‐old woman with a familial history of coronaropathy was first treated with erenumab 70 mg for 6 months and then increased to 140 mg. Almost 5 months after, the patient presented chest pain, increased troponin, and abnormal electrocardiogram. A myocardial infarction without coronarography abnormality was diagnosed through MRI.ConclusionFurther evidence is needed to assess the risk of myocardial infarction in patients treated with a CGRP‐mab. In patients over 40 years of age, the risk of coronary or cardiovascular events should be assessed using risk tables or algorithms to take into account cardiovascular risk factors. This may be complemented by appropriate examinations to measure the burden of coronary atherosclerosis, if necessary.
Complicated streamer dynamics in petal‐like patterns formed on the substrate downstream of an argon plasma jet
Authors: Wu Kaiyue , Zhao Na , Wu Jiacun , Zhang Furong , Niu Mengyu , Ran Junxia , Jia Pengying , Li Xuechen 
Published: May 2022

AbstractStreamer behaviors, related to discharge patterns, can determine the distribution of active species, which play an important role in the applications of the plasma jet. In this article, petal‐like patterns formed on the substrate are observed for the first time downstream of an argon plasma jet. The penta‐petalous pattern is taken as an example to discuss the pattern formation mechanism, which results from two positive discharges (Dp1 and Dp2) and one negative discharge (Dn) in every voltage cycle. Fast photography is implemented to reveal the complicated streamer dynamics of Dp2. Results indicate that Dp2 with a low Q undergoes a stripe phase, a homogeneous phase, and a branch phase. The complicated streamer dynamics of Dp2 are analyzed based on optical emission spectra.
Role of soluble triggering receptors expressed on myeloid cells‐1 and 25‐hydroxy vitamin D as early diagnostic markers of neonatal Ventilator‐associated pneumonia: A prospective cohort study
Authors: El‐Sheikh Mai , Elmahdy Heba , Nassar Mohammed , Fouda Mohamed , Ibrahim Ashraf , Al‐Beltagi Mohammed 
Published: May 2022

AbstractBackgroundVentilator‐associated pneumonia (VAP) is one of the most common causes of nosocomial pneumonia in ventilated neonates. Nevertheless, its diagnosis is challenging due to the nonspecific clinical parameters and the lack of sensitive biomarkers. The main objective of this study was to compare soluble triggering receptors expressed on myeloid cells‐1 (sTREM‐1) and 25‐hydroxy vitamin D as early predictors of neonatal VAP.MethodsThis prospective cohort study included 85 ventilated neonates divided into the VAP group (n = 33) and the non‐VAP group (n = 52). sTREM‐1 levels in the endotracheal aspirate (ETA) and serum 25‐hydroxy vitamin D levels were measured on the third and seventh days following mechanical ventilation. The Ethical and Research Committee approved the study at Tanta University Hospitals, Egypt (with the Approval code: 32751/12/18).ResultsThe sTREM‐1 cutoff value of >0.46 and >0.44 ng/ml at 3 and 7 days had a sensitivity of 93.94% and 96.97%, a specificity of 92.31% and 100%, and an area under the receiver operating characteristic curve (AUC) of 0.963 and 0.993, respectively, to predict the development of neonatal VAP. A serum 25‐hydroxy vitamin D cutoff value of ≤17.5 ng/ml at 3 and 7 days had a sensitivity of 90.91% and 81.82%, a specificity of 75% and 78.85%, and area under the curve of 0.877 and 0.939, respectively.ConclusionBoth sTREM‐1 in ETA and serum 25‐hydroxy vitamin D could be used as early predictors of neonatal VAP, but sTREM‐1 appears more useful.
Emergency department‐initiated home oxygen for viral bronchiolitis: A cost‐effectiveness analysis
Authors: Rodríguez‐Martínez Carlos E. , Sossa‐Briceño Monica P. , Nino Gustavo 
Published: May 2022

AbstractObjectiveThe use of emergency department (ED)‐initiated outpatient oxygen therapy has been considered to be a possible alternative to hospitalization for otherwise healthy‐appearing, well‐hydrated infants with uncomplicated disease. However, a formal economic evaluation of this treatment strategy is lacking. The aim of the present study was to compare the cost‐effectiveness of ED‐initiated outpatient oxygen therapy versus conventional inpatient hospitalization in infants with uncomplicated hypoxic bronchiolitis living in Bogota, the high‐altitude capital city of Colombia, a middle‐income country (MIC).MethodsA decision analysis model was developed to estimate the cost‐effectiveness of ED‐initiated outpatient oxygen therapy versus hospitalization. The main outcome of the model was avoidance of admission to a high‐dependency unit.ResultsCompared to hospitalization, ED‐initiated outpatient oxygen therapy was associated with lower total costs (US$306.7 vs. US$638.7 average cost per patient) and a higher probability of avoidance of admission to a high‐dependency unit (0.9528 vs. 0.8960), thus leading to dominance. The results were robust to deterministic and probabilistic sensitivity analyses.ConclusionsOur study suggests that in infants attending the ED with an uncomplicated hypoxic bronchiolitis episode in the city of Bogota, a high‐altitude city, ED‐initiated outpatient oxygen therapy is a dominant strategy compared to conventional inpatient hospitalization, because it involves a higher probability of avoidance of admission to a high‐dependency unit, at lower total treatment costs.
Spin‐Chain‐Star Systems: Entangling Multiple Chains of Spin Qubits
Authors: Grimaudo Roberto , Magalhães de Castro Antonio Sergio , Messina Antonino , Valenti Davide 
Published: May 2022

AbstractWe consider spin‐chain‐star systems characterized byN‐wise many‐body interactions between the spins in each chain and the central one. We show that such systems can be exactly mapped into standard spin‐star systems through unitary transformations. Such an approach allows the solution of the dynamic problem of an spin‐chain‐star model and transparently shows the emergence of quantum correlations in the system, based on the idea of entanglement between chains.