bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Affordable Homestead Implements for Stress Reduction on Body Parts amongst Farm Workers of Khammam District, India
Authors: Kumar J. Hemantha , Suneetha W. Jessie , Chaitanya V. , Ravi Kumar K. , Nagaraju D. , Reddy R. Uma , V. Prasad J. 
Published: August 2022

The rural populations consisting of marginal and poor farmers are dependent on labourers for all farm related activities like sowing / planting of paddy, harvesting of agricultural and horticultural produce and application of pesticides which can be very costly. These labourers also face a lot of problems in sowing / planting of paddy as it has to be done by bending down continuously or during application of pesticides to cotton fields drift can be major health concern and harvesting different produce like bhendi due to its thorny spikes and capsaicin content of chilies. In view of this, KVK, Wyra, Khammam has assessed cost effective homestead implements and is relentlessly trying to popularize them. These included use of protective clothing during application of pesticides, rolling stem applicator for controlling sucking pest in cotton, knitted gloves for bhendi plucking and chilli finger guard for its plucking. These simple and cost-effective farm implements helped farm women in drudgery reduction, ergonomic stress on various body parts, improved work efficiency, decreased labour cost and body allergies. Protective clothing reduced itching, irritation, skin allergies, burning, vomiting, headache and faintness over a month’s time, rolling stem applicator was ecofriendly and decreased the amount of chemicals, knitted gloves for bhendi plucking reduced the bruising and repeated damage to fingers during harvesting and chilli finger guard. The reduction in stress on body parts automatically improved the work efficiency among farm workers.
Effect of Tillage and Nutrient Management Practices on Growth, Yield and Oil Quality of Rice Fallow Sesame
Authors: Hari Priya K. , Ramesh K. , Deep Tuti Mangal , Anjaiah T. , A. Qureshi M. A. , Yadav Pradhuman 
Published: August 2022

A field experiment was conducted during year 2021-22 at ICAR-Indian Institute of Rice Research, Rajendranagar, Hyderabad to study the effect of tillage and nutrient management practices on growth, yield and quality of sesame grown in rice fallows. The experiment was laid out in split plot design with 18 treatments comprised of three main plot treatments i.e., A1: Reduced tillage (Cultivator once) , A2: Conventional tillage (Cultivator twice with rotavator once) and A3: Minimum tillage (tillage in the row zone/uprooting soil in the seed zone with hand held dibbler) with six sub-plot treatments i.e., B1: Control , B2: 25% RDF, B3: 50% RDF, B4 : 75% RDF, B5 : 100% RDF and B6 : 125 % RDF replicated three times. Results revealed that there was a significant improvement in growth and yield of rice fallow sesame with conventional tillage and application of 125% RDF. Significantly taller plants, higher drymatter production, seed yield and stalk yield was obtained with conventional tillage. While,125% RDF recorded significantly higher growth and yield parameters when compared to lower fertilizer doses. There was no significant influence of tillage and nutrient management practices on oil content and fatty acid composition. However, with increase in fertilizer dose upto 125% RDF there was a slight change in oil content. Significant effect of tillage and nutrient management was observed in oil yield. Conventional tillage proved to be beneficial as it increased oil yield significantly. With increase in fertilizer doses there was appreciable increase in linoleic and oleic acid content. But stearic acid, palmitic acid and linolenic acid contents decreased at higher fertilizer doses.
Zn and B Mediated Effect on Yield Attribute, Yield, and Nutrient Uptake in Lentil (Lens culinaris Medick.)
Authors: Kumar Yadav Praveen , Kumar Satendra , Kumar Vivek , Dixit Vidhu , Verma Shikhar , Singh Vikash 
Published: August 2022

A field experiment was conducted during rabi season 2020-21 at the Crop Research Center of Sardar Vallabhbhai Patel University of Agriculture and Technology, Meerut (U.P.) to evaluate the Effect of Zn and B application. Ten treatments comprising control, RDF, Zn and B in a different combination were tested in a randomized block design with three replications. The experimental results revealed that yield attributing traits viz. number of pods plant-1, number of grain plant-1, grain yield plant-1, test weight and biological yield, grain yield, straw yield and content and uptake of N, P, K, Zn, S, and B in lentil differed significantly among different treatments. Growth parameters were significantly better in the treatment T10 (RDF + Boron 2 kg ha-1 + Zinc 5 kg ha-1). The highest grain yield was recorded in T10 RDF + Boron 2 kg ha-1 + Zinc 5 kg ha-1 which were statistically at par with T8. It is concluded based on the study that the application of RDF + Boron 2 kg ha-1 + Zinc 5 kg ha-1 with Zn, and B (T10) gave best results (Grain yield increased by 26.7%, 25.7%, 21%, 22.9%, 17.2% and 59.1% over T1, T3, T4, T5, T6 and T1, respectively) and proved to be beneficial for rabi lentil followed by RDF + Boron 2 kg ha-1 + Zinc 5 kg ha-1 (T9). The balanced and combined use of Zn, and B along with N, P, K and S in lentil improved the yield attribute, yield, and total uptake of nutrients along with maintaining the soil fertility.
Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat
Authors: Bidingha Ronald À. Goufani , Bilanda Danielle Claude , Donfack Mireille Flore Metchi , Oumarou Bibi-Farouck Aboubakar , Nguegan Lohik Mbolang , Owona Pascal Emmanuel , Tcheutchoua Yannick Carlos , Djomeni Paul Désiré Dzeufiet , Dimo Théophile , Kamtchouing Pierre 
Published: August 2022

Background and Aim: Cardiovascular complications are the main cause of morbidity and mortality in hypertensive diabetic patients. They develop due to microvasculopathy, myocardial hypertrophy and cardiac fibrosis. In the present study, the activity of aqueous extract of Erythrina senegalensis on cardiovascular complications in diabetic hypertensive rats was evaluated.
Experimental Procedure: The model of hypertensive diabetic rats was obtained by daily oral administration of sucrose (15%) and 40° ethanol at doses of 1.5 and 5 g/kg respectively for six weeks, followed by an intravenous injection of streptozotocin (35 mg/kg). After four weeks of complications, the diabetic hypertensive rats were divided into six groups of 5 animals each, and received the different treatments for four weeks where blood glucose level was taken weekly. At the end of the treatments, the animals were anaesthetised and the arterial pressures and electrocardiograph were recorded by the direct method. Then the aorta and heart were removed for biochemical calorimetric analysis and histological evaluation.
Results and Conclusion: In the diabetic hypertensive animals the results showed chronic hyperglycaemia associated with high blood pressure. On the electrocardiogram there was a cardiac arrhythmia manifested by a significant decrease in the duration of the PR, QRS, RR, QTc segments, ST interval, P, QRS and T waves, a decrease in the amplitude of the QRS and T waves. There was a significant increase in total cholesterol, triglyceride atherogenic index and a decrease in HDL-cholesterol with a change in the cardiac ionogram and oxidative status in the aorta and heart. The different treatments improved these parameters and cardiovascular function. These results suggest that the extract of E. senegalensis by the presence of several bioactive compounds would possess cardioprotective, hypoglycaemic, hypotensive and antioxidant properties.
Comparative Phytochemical Analysis and Antiradical Activity of Five Plants Used for the Treatment of Type 2 Diabetes in Benin
Authors: Seton S. , Koukoui O. , Koudoro Y. , Amagbegnon J. B. , Betira M. , Sonounameto F. , Agbangnan C. P. 
Published: August 2022

Background: Diabetes remains a real public health problem in the world today. Although considered a disease of rich countries, today diabetes is increasingly a major concern in developing countries and particularly in sub-Saharan Africa. In Benin, its prevalence in 2015 was 12.4%.
Objective: This work aimed to compare the secondary metabolites, the content of phenolic compounds (total phenol, flavonoid) and the antiradical power of five plants (Bambusa vulgaris Schrad. Ex Wendel; Parkia biglobosa (Jacq.) R. Br. Ex G. Don; Mangifera indica L.; Saccharum officinarum L.; and Annona muricata L.) used in Benin by traditional healers to treat type 2 diabetes.
Materials and Methods: Secondary metabolites were identified by coloration and precipitation reactions specific to each family of metabolites. Total phenols were determined by Folin Ciocalteu method. The aluminum trichloride method has been used to quantify total flavonoids. The antiradical capacity was evaluated by 2,2-diphenyl-l-picrylhydrazyl (DPPH).
Results: Plants which leaves were higher in total phenols were Mangifera indica, Parkia biglobosa and Bambusa vulgaris while Annona muricata and Parkia biglobosa were the richest plants in flavonoids. The hydroethanolic extract of leaves of Bambusa vulgaris (IC50=0.28mg/mL), Parkia biglobosa (IC50=0.3mg/mL) and Mangifera indica (IC50=2.5mg/mL) showed more pronounced antiradical activity than vitamin C (IC50=3.2 mg/mL) which were synthetic antioxidant.
Conclusion: Our results showed that among the five plants studied Mangifera indica, Parkia biglobosa and Bambusa vulgaris were the richest in total phenols and also those whose leaf extracts had the highest antiradical activities. These three plants could therefore be considered as potential remedies for type 2 diabetes and its complications.
Over 10% Efficient Cu2CdSnS4 Solar Cells Fabricated from Optimized Sulfurization
Authors: Fan Ping , Lin Jinhong , Hu Juguang , Yu Zixuan , Zhao Yunhai , Chen Shuo , Zheng Zhuanghao , Luo Jingting , Liang Guangxing , Su Zhenghua 
Published: August 2022

AbstractAt present, Kesterite‐based thin‐film solar cells, such as Cu2ZnSnS4 solar cells, involve serious band‐tailed states, which leads to low open‐circuit voltage, thereby hindering the further improvement of device performance. In stannite‐based materials, such as Cu2CdSnS4, the substitution of Zn with Cd can effectively suppress CuCd‐related point defects and defect clusters; thus, the band‐tailing state is few, which has attracted considerable research attention. In this work, on the basis of using optimized sulfurization and optimizing ratios (Cu/Cd+Sn) and temperatures, Cu2CdSnS4 thin films can be obtained with good quality and single‐phase composition, in which the device prepared at a ratio of 0.83 and 590 °C has the highest efficiency. Defect analysis shows that the substitution of Zn with Cd can effectively reduce CuCd‐related defects and defect clusters (such as 2CuCd+SnCd) and also decrease Urbach energy, fluctuations of bandgap, and electrostatic potential compared with kesterite‐based devices. In particular, Cu2CdSnS4 thin‐film solar cell prepared under optimized conditions (the ratio of 0.83 and 590 °C) has the minimum reverse saturation current, red shift, and the maximum minority carrier diffusion length. Therefore, an efficiency over 10% Cu2CdSnS4 thin‐film solar cell is reported, which shows the highest efficiency among stannite‐based solar cells to date.
Metal Confined in 2D Membranes for Molecular Recognition and Sieving towards Ethylene/Ethane Separation
Authors: Cheng Long , Guo Yanan , Liu Quan , Liu Guozhen , Li Renhao , Chen Xi , Zeng Hui , Liu Gongping , Jin Wanqin 
Published: August 2022

AbstractMembranes with nanochannels have exhibited great potential in molecular separations, while it remains a great challenge to separate molecules with very close physical properties and kinetic diameters (e.g., ethylene/ethane) owing to the lack of size‐sieving property and specific affinity. Herein, a metal confined 2D sub‐nanometer channel is reported to successfully discriminate ethylene over ethane via molecular recognition and sieving. Transition metal cations are paired with polyelectrolyte anions to achieve high dissociation activity, forming reversible complexation with ethylene. Aberration‐corrected transmission electron microscopy observes that the metals with size of ≈2 nm are uniformly confined in graphene oxide (GO) interlayer channels with average height of ≈0.44 nm, thereby cooperating the size‐sieving effect with a molecular recognition ability toward ethylene and stimulating its selective transport over ethane. The resulting ultrathin (≈60 nm) membrane exhibits superior ethylene/ethane separation performance far beyond the polymeric upper‐bound. Density functional theory (DFT) and molecular dynamic simulations reveal that the metal@2D interlayer channel provides a molecular recognition pathway for selective gas transport. The proposed metal confined in 2D channel with molecular recognition and sieving properties would have broad application in other related fields such as single‐atom catalysis, sensor and energy conversion.
Surface Anchoring‐Induced Robust Luminescence Thermal Quenching Suppression in Shell‐Free Perovskite Nanocrystals
Authors: Hu Xudong , Wu Yuting , Wang Yue , Xu Lili , Zhang Shengli , Wang Junhui , Wu Kaifeng , Liu Yang , Li Yuelei , Li Xiaoming 
Published: August 2022

AbstractThe luminescence thermal quenching (LTQ) behavior is one of the detrimental effects which result in poor stability and hinder the practical applications of luminescent nanocrystals (NCs) severely. Suppressing the LTQ effect is fundamentally important, especially for the recent rising star lead halide perovskite NCs while related investigations are rare. Herein, taking CsPbBr3 NCs with high photoluminescence quantum yield (PLQY) as examples, a surface anchoring mechanism is proposed and the LTQ effect is successfully overcome. By introducing hybrid ligand system with large binding effect and steric hindrance, ligand desorption induces irreversible LTQ effect and the formation of surface atom vibration related transient traps is suppressed. As a result, 96.3% and 75.6% of the initial PL intensity are maintained up to 378 and 423 K, respectively, which are even superior to conventional core–shell NCs. Notably, after being treated under 333 K for 15 days, a PL intensity remnant of >88.4% is achieved. Such anti‐LTQ mechanism is also extended to blue perovskite NCs. Temperature‐tolerant stimulated emission and high temperature lasing phenomenon are fulfilled with considerable thermal stability. This work provides a new mechanism which can possibly help to solve the bottleneck toward practical luminescence applications for perovskite nanostructures.
Cu‐Oxide Nanoparticles Catalyzed Synthesis of Nitriles and Amides from Alcohols and Ammonia in Presence of Air
Authors: Senthamarai Thirusangumurugan , Poovan Fairoosa , Alenad Asma M. , Rockstroh Nils , Rabeah Jabor , Bartling Stephan , Baráth Eszter , Natte Kishore , Jagadeesh Rajenahally V. 
Published: August 2022

AbstractThe synthesis and functionalization of nitrogen‐containing compounds continue to be important due to their wide applications. In particular, the preparation of nitriles and amides applying cost‐effective and green methodologies is of central importance because these products represent valuable fine and bulk chemicals and serve as key precursors and central intermediates in organic synthesis and drug discovery as well as materials. Here, the preparation of nitriles and primary amides from alcohols and ammonia by a heterogeneous Cu‐catalyzed aerobic oxidation process is reported. The optimal catalyst for this synthesis is based on supported copper oxide‐nanoparticles, which are prepared by the impregnation and pyrolysis of simple copper nitrate on carbon. Applying these reusable nanoparticles, various simple, substituted, and functionalized aromatic, heterocyclic, and aliphatic nitriles are synthesized starting from inexpensive and easily accessible alcohols and ammonia in the presence of air. In addition, the synthesis of selected primary amides in a water medium is also performed using these Cu nanoparticles.
Dimethyl 2‐Methylglutarate (Iris): A Green Platform for Efficient Liquid‐Phase Exfoliation of 2D Materials
Authors: D'Olimpio Gianluca , Occhiuzzi Jessica , Lozzi Luca , Ottaviano Luca , Politano Antonio 
Published: August 2022

AbstractLiquid‐phase exfoliation of bulk crystals of layered materials, held together by weak interlayer van der Waals forces, is an ideal platform for scalable synthesis of nanosheets. However, it is mandatory to substitute existing solvents, regrettably displaying severe limitations due to toxicity. Here, dimethyl 2‐methylglutarate (Rhodiasolv Iris) is validated for efficient liquid‐phase exfoliation of selected van der Waals materials, namely, MoS2, WS2, GeSe, and graphite. Here, we show that Iris‐assisted liquid phase exfoliation provides high yield (up to 52%) of flakes of 2D materials with aspect ratio as high as 500. Considering the various advantages of Iris over the state‐of‐the‐art solvents, including the absence of toxicity and its biodegradability, this work opens new possibilities for the ecofriendly production of 2D materials and for their extensive usage in industrial processes hitherto semi‐unexplored, owing to the toxicity of state‐of‐the‐art solvents (including the production of drinkable water or fruit juice concentration). Accordingly, the validation of Iris for sustainable liquid‐phase exfoliation of van der Waals crystals has intrinsic outstanding potential commercial impact. Moreover, here the values of the surface tension, Hansen solubility parameter, and viscosity of Rhodiasolv Iris are reported for the first time, which will be relevant also for any other sustainable process based on this new green solvent.
Oxygen‐Generated Hierarchical‐Structured AuNRs@MnO2@SiO2 Nanocarrier for Enhanced NIR‐ and H2O2‐Responsive Mild‐Hyperthermia Photodynamic/Photothermal Combined Tumor Therapy
Authors: Zheng Wen‐Jie , Zhou Ze‐Lei , Lv Qi‐Yan , Song Xiaojie , Zhang Wen‐Xing , Cui Hui‐Fang 
Published: August 2022

AbstractTumor hypoxia greatly restricts photodynamic therapy (PDT) efficiency. Photothermal therapy (PTT) implemented at high temperatures induces local skin burning and surrounding tissue damage. Herein, an near‐infrared (NIR)‐ and H2O2‐double responsive heat‐ and O2‐generating core–shell–shell AuNRs@MnO2@SiO2 nanocarrier with Au nanorods (AuNRs) as core and MnO2 as sandwiched nanolayer is developed to realize enhanced photodynamic/photothermal combined tumor therapy at mild‐hyperthermia temperatures. Coating poly‐l‐lysine on AuNRs is capable of preventing AuNRs from aggregation and facilitating the on‐site growth of MnO2. The mesoporous SiO2 nanoshell provides large loading sites for payload indocyanine green (ICG). The MnO2 nanolayer greatly enhances the singlet oxygen (1O2) generation efficiency of ICG both in testing tubes and in cancer cells. Consequently, the O2‐enhanced PDT endows the AuNRs@MnO2@SiO2‐ICG nanoparticles (NPs) dramatically stronger antitumor effect both in vitro and in vivo. Their tumor growth inhibition ratio (67.6%) is significantly higher than that of AuNRs@SiO2‐ICG (28.5%) after one dose intratumor injection and NIR irradiation. Together with their good biosafety, the AuNRs@MnO2@SiO2‐ICG is promisingly translational. The multifunctionality should provide the AuNRs@MnO2@SiO2 NPs a nanocarrier platform for various therapeutic agents to modulate the tumor microenvironment and enhance tumor therapy efficiency.
D2 Plot, a Matrix of DNA Density and Distance to Periphery, Reveals Functional Genome Regions
Authors: Che Yizhuo , Yang Xiaofei , Jia Peng , Wang Tingjie , Xu Dan , Guo Tianxue , Ye Kai 
Published: August 2022

AbstractThe execution of biological activities inside space‐limited cell nuclei requires sophisticated organization. Current studies on the 3D genome focus on chromatin interactions and local structures, e.g., topologically associating domains (TADs). In this study, two global physical properties: DNA density and distance to nuclear periphery (DisTP), are introduced and a 2D matrix, D2 plot, is constructed for mapping genetic and epigenetic markers. Distinct patterns of functional markers on the D2 plot, indicating its ability to compartmentalize functional genome regions, are observed. Furthermore, enrichments of transcription‐related markers are concatenated into a cross‐species transcriptional activation model, where the nucleus is divided into four areas: active, intermediate, repress and histone, and repress and repeat. Based on the trajectories of the genomic regions on D2 plot, the constantly active and newly activated genes are successfully identified during olfactory sensory neuron maturation. The analysis reveals that the D2 plot effectively categorizes functional regions and provides a universal and transcription‐related measurement for the 3D genome.
S100A9 Derived from Chemoembolization‐Induced Hypoxia Governs Mitochondrial Function in Hepatocellular Carcinoma Progression
Authors: Zhong Chengrui , Niu Yi , Liu Wenwu , Yuan Yichuan , Li Kai , Shi Yunxing , Qiu Zhiyu , Li Keren , Lin Zhu , Huang Zhenkun , Zuo Dinglan , Yang Zhiwen , Liao Yadi , Zhang Yuanping , Wang Chenwei , Qiu Jiliang , He Wei , Yuan Yunfei , Li Binkui 
Published: August 2022

AbstractTransarterial chemoembolization (TACE) is the major treatment for advanced hepatocellular carcinoma (HCC), but it may cause hypoxic environment, leading to rapid progression after treatment. Here, using high‐throughput sequencing on different models, S100 calcium binding protein A9 (S100A9) is identified as a key oncogene involved in post‐TACE progression. Depletion or pharmacologic inhibition of S100A9 significantly dampens the growth and metastatic ability of HCC. Mechanistically, TACE induces S100A9 via hypoxia‐inducible factor 1α (HIF1A)‐mediated pathway. S100A9 acts as a scaffold recruiting ubiquitin specific peptidase 10 and phosphoglycerate mutase family member 5 (PGAM5) to form a tripolymer, causing the deubiquitination and stabilization of PGAM5, leading to mitochondrial fission and reactive oxygen species production, thereby promoting the growth and metastasis of HCC. Higher S100A9 level in HCC tissue or in serum predicts a worse outcome for HCC patients. Collectively, this study identifies S100A9 as a key driver for post‐TACE HCC progression. Targeting S100A9 may be a promising therapeutic strategy for HCC patients.
Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy
Authors: Song Chuanhui , Huang Danqing , Zhao Cheng , Zhao Yuanjin 
Published: August 2022

AbstractAntibiotics provide promising strategies for treating periodontitis, while their delivery and controllable release with desired oral retention remain challenging. Here, inspired by the unique suction‐cup structures of abalones, a novel adhesive and photo‐responsive microparticle (MP) delivery system is developed to treat periodontitis through microfluidic electrospray technology. Such MPs are generated by quickly ionic cross‐linking of sodium alginate together with photo‐curing of poly(ethylene glycol) diacrylate of the distorted microfluidic droplets during their high‐speed dropping into calcium chloride solution. Attributing to their unique concave structures, the abalone‐inspired MPs exhibit desired underwater adhesion ability and stability under running water. In addition, due to the loading of antibiotics minocycline hydrochloride and near‐infrared (NIR)‐responsive black phosphorus during their fabrication, the resultant MPs can not only eradicate bacteria directly, but also realize a controllable and effective drug release upon NIR irradiation. Based on these features, it is demonstrated from in vivo periodontitis that the abalone‐inspired MPs are firmly adhesive and can controlled‐release drugs on the tooth, and thus have outstanding antibacterial efficacy against Porphyromonas gingivalis. These results indicate the particular values of the abalone‐inspired MPs for oral‐related disease treatment.