bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scalable recommendation systems based on finding similar items and sequences
Authors: Uzun‐Per Meryem , Gurel Ahmet Volkan , Can Ali Burak , Aktas Mehmet S. 
Published: January 2022

AbstractThe rapid growth in the airline industry, which started in 2009, continued until the COVID‐19 era, with the annual number of passengers almost doubling in 10 years. This situation has led to increased competition between airline companies, whose profitability has decreased considerably. They aimed to increase their profitability by making services like seat selection, excess baggage, Wi‐Fi access optional under the name of ancillary services. To the best of our knowledge, there is no recommendation system for recommending ancillary services for airline companies. Also, to the best of our knowledge, there is no testing framework to compare recommendation algorithms considering their scalabilities and running times. In this paper, we propose a framework based on Lambda architecture for recommendation systems that run on a big data processing platform. The proposed method utilizes association rule and sequential pattern mining algorithms that are designed for big data processing platforms. To facilitate testing of the proposed method, we implement a prototype application. We conduct an experimental study on the prototype to investigate the performance of the proposed methodology using accuracy, scalability, and latency related performance metrics. The results indicate that the proposed method proves to be useful and has negligible processing overheads.
Adolescent maladaptive schemas and childhood abuse and neglect: A systematic review and meta‐analysis
Authors: May Tamara , Younan Rita , Pilkington Pamela D. 
Published: January 2022

AbstractThis study aimed to review evidence on the associations between childhood emotional, physical and sexual abuse; neglect and bullying and early maladaptive schemas, as measured in adolescence. PubMed, PsycInfo and CINAHL were searched to identify peer‐reviewed studies reporting original quantitative data on the association between early maladaptive schemas or schema domains (e.g., Disconnection and Rejection) and childhood emotional, physical and sexual abuse; neglect and bullying, measured in individuals aged up to 18 years. Meta‐analyses were conducted to estimate the magnitude of the associations between schemas and childhood experiences. Twelve studies were included: Seven explored schemas, and five examined schema domains. Most studies had somewhat representative samples that were adequate in size, and all used validated measures of schemas or schema domains. Three studies explored emotional neglect, two each for emotional abuse, physical abuse and peer problems, one explored family violence and one adolescent stressors. Meta‐analyses indicated small to medium pooled associations between emotional abuse and Emotional Deprivation, r = .33 (95% CI [.19, .46]) and Subjugation, r = .32 (95% CI [.14,.47]) and emotional neglect and Mistrust Abuse, r = .41 (95% CI [.32, .49]), Abandonment, r = .25 (95% CI [.22, .28]), Social Isolation r = .23 (95% CI [.10, .35]) and Failure, r = .35 (95% CI [.26, .44]). Associations between childhood abuse and neglect experiences and schemas were evident in adolescents. There were limited data on some adverse experiences including sexual abuse and neglect. The evidence thus far suggests that maladaptive schemas are related to experiences of childhood emotional abuse and neglect and are evident before adulthood.
Impact of corporate social responsibility on financial expert CEOs' turnover in heavily polluting companies in Bangladesh
Authors: Dhar Bablu Kumar , Harymawan Iman , Sarkar Sabrina Maria 
Published: January 2022

AbstractBased on the empirical data of heavily polluting companies in Bangladesh from 2010 to 2019, this paper conducts an empirical analysis of changes in the financial background of top management on the performance of social responsibilities of heavily polluting companies. Results from the analysis among 212 listed companies on the Dhaka Stock Exchange indicate a significant negative correlation between changes in the financial backgrounds of top management and their performance on social responsibilities. In heavily polluting firms, corporate social responsibility (CSR) performance will deteriorate after the takeover of a new financial expert CEO. Furthermore, the present study found that internal control has a significant negative and moderating effect on the above relationship. As a result, the higher the quality of internal control, the smaller the negative impact of the change in the turnover of financial expert CEO on CSR performance.
Destabilization of macrophage migration inhibitory factor by 4‐IPP reduces NF‐κB/P‐TEFb complex‐mediated c‐Myb transcription to suppress osteosarcoma tumourigenesis
Authors: Zheng Lin , Feng Zhenhua , Tao Siyue , Gao Jiawei , Lin Ye , Wei Xiaoan , Zheng Bingjie , Huang Bao , Zheng Zeyu , Zhang Xuyang , Liu Junhui , Shan Zhi , Chen Yilei , Chen Jian , Zhao Fengdong 
Published: January 2022

AbstractBackgroundAs an inflammatory factor and oncogenic driver protein, the pleiotropic cytokine macrophage migration inhibitory factor (MIF) plays a crucial role in the osteosarcoma microenvironment. Although 4‐iodo‐6‐phenylpyrimidine (4‐IPP) can inactivate MIF biological functions, its anti‐osteosarcoma effect and molecular mechanisms have not been investigated. In this study, we identified the MIF inhibitor 4‐IPP as a specific double‐effector drug for osteosarcoma with both anti‐tumour and anti‐osteoclastogenic functions.MethodsThe anti‐cancer effects of 4‐IPP were evaluated by wound healing assay, cell cycle analysis, colony formation assay, CCK‐8 assay, apoptosis analysis, and Transwell migration/invasion assays. Through the application of a luciferase reporter, chromatin immunoprecipitation assays, and immunofluorescence and coimmunoprecipitation analyses, the transcriptional regulation of the NF‐κB/P‐TEFb complex on c‐Myb‐ and STUB1‐mediated proteasome‐dependent MIF protein degradation was confirmed. The effect of 4‐IPP on tumour growth and metastasis was assessed using an HOS‐derived tail vein metastasis model and subcutaneous and orthotopic xenograft tumour models.ResultsIn vitro, 4‐IPP significantly reduced the proliferation and metastasis of osteosarcoma cells by suppressing the NF‐κB pathway. 4‐IPP hindered the binding between MIF and CD74 as well as p65. Moreover, 4‐IPP inhibited MIF to interrupt the formation of downstream NF‐κB/P‐TEFb complexes, leading to the down‐regulation of c‐Myb transcription. Interestingly, the implementation of 4‐IPP can mediate small molecule‐induced MIF protein proteasomal degradation via the STUB1 E3 ligand. However, 4‐IPP still interrupted MIF‐mediated communication between osteosarcoma cells and osteoclasts, thus promoting osteoclastogenesis. Remarkably, 4‐IPP strongly reduced HOS‐derived xenograft osteosarcoma tumourigenesis and metastasis in an in vivo mouse model.ConclusionsOur findings demonstrate that the small molecule 4‐IPP targeting the MIF protein exerts an anti‐osteosarcoma effect by simultaneously inactivating the biological functions of MIF and promoting its proteasomal degradation. Direct destabilization of the MIF protein with 4‐IPP may be a promising therapeutic strategy for treating osteosarcoma.
Large herbivores facilitate a dominant grassland forb via multiple indirect effects
Authors: Zhong Zhiwei , Li Xiaofei , Smit Christian , Li Tianyun , Wang Ling , Aschero Valeria , Vázquez Diego , Ritchie Mark , Cushman J. Hall , Wang Deli 
Published: January 2022

AbstractWhile large herbivores are critically important components of terrestrial ecosystems and can have pronounced top‐down effects on plants, our understanding of the underlying mechanisms driving these effects remains incomplete. Large herbivores can alter plant growth, reproduction, and abundance through direct effects (predominantly consumption) and through indirect effects via altered interactions with abiotic factors and other species. We know considerably less about these indirect effects than the direct effects. Here, we integrate medium‐ and small‐scale field experiments to investigate how a large vertebrate herbivore, cattle (Bos taurus), affects the aboveground biomass of a dominant forb species, Artemisia scoparia, via diverse direct and indirect pathways in a temperate grassland in northeast China. Although cattle consumed this forb, its biomass increased significantly in response to grazing, due to multiple indirect positive effects that outweighed the direct negative effects of consumption. Cattle preferentially consumed the competing grass Leymus chinensis, and altered Artemisia microhabitats by reducing total plant cover and litter biomass and by increasing the abundance of co‐occurring ant species (e.g., Formica spp. and Lasius spp.). This led to additional indirect positive effects on A. scoparia likely due to (1) increased light availability in understory layers and other limiting resources (e.g., soil nutrients and moisture) caused by removal of competitors and plant litter at the soil surface and (2) the changes in resource availability (e.g., soil nutrients and moisture) associated with ant colonies. Our results show that large herbivores can affect plant growth not only via direct consumption, but also via multiple indirect effects. Focusing on the causes and consequences of herbivore‐induced indirect effects will not only help us to better understand the influence of these animals in ecological systems, but will also lead to more effective land management and conservation practices in the regions they inhabit.
Diet analysis using generalized linear models derived from foraging processes using R package mvtweedie
Authors: Thorson James T. , Arimitsu Mayumi L. , Levi Taal , Roffler Gretchen H. 
Published: January 2022

AbstractDiet analysis integrates a wide variety of visual, chemical, and biological identification of prey. Samples are often treated as compositional data, where each prey is analyzed as a continuous percentage of the total. However, analyzing compositional data results in analytical challenges, for example, highly parameterized models or prior transformation of data. Here, we present a novel approximation involving a Tweedie generalized linear model (GLM). We first review how this approximation emerges from considering predator foraging as a thinned and marked point process (with marks representing prey species and individual prey size). This derivation can motivate future theoretical and applied developments. We then provide a practical tutorial for the Tweedie GLM using new package mvtweedie that extends capabilities of widely used packages in R (mgcv and ggplot2) by transforming output to calculate prey compositions. We demonstrate this approach and software using two examples. Tufted Puffins (Fratercula cirrhata) provisioning their chicks on a colony in the northern Gulf of Alaska show decadal prey switching among sand lance and prowfish (1980–2000) and then Pacific herring and capelin (2000–2020), while wolves (Canis lupus ligoni) in southeast Alaska forage on mountain goats and marmots in northern uplands and marine mammals in seaward island coastlines.
Step‐by‐step typing for the accurate diagnosis of concurrent light chain and transthyretin cardiac amyloidosis
Authors: Moriyama Hidenori , Kitakata Hiroki , Endo Jin , Ikura Hidehiko , Sano Motoaki , Tasaki Masayoshi , Sakai Shunta , Ueda Mitsuharu , Fukuda Keiichi 
Published: January 2022

AbstractWhile 99mTc‐pyrophosphate scintigraphy is clearly useful in diagnosing transthyretin amyloid cardiomyopathy (ATTR‐CM), it is necessary to know the pitfalls of this test for proper use. We present a rare case of concurrent ATTR‐CM and amyloid light chain (AL) cardiomyopathy. The patient showed congestive heart failure with left ventricular hypertrophy. 99mTc‐pyrophosphate scintigraphy revealed abnormal cardiac uptake of Grade 3, a typical feature for ATTR‐CM. However, the patient showed renal impairment with proteinuria and the presence of monoclonal gammopathy, which rather suggested AL amyloidosis. Endomyocardial biopsy, immunohistochemistry, and proteomic analysis by laser microdissection with liquid chromatography‐coupled tandem mass spectrometry were performed, which finally confirmed both ATTR‐CM and AL cardiomyopathy. This case implicates the importance of combining examinations and precisely interpreting the results to diagnose cardiac amyloidosis accurately.
Effects of potato and sweet potato flour addition on properties of wheat flour and dough, and bread quality
Authors: Meng Hongwei , Xu Chong , Wu Meiying , Feng Ying 
Published: January 2022

AbstractThe effects of 10%–30% of wheat flour substitution with potato flour (PF) and sweet potato flour (SPF) on the flour and dough properties, the total polyphenol (TPC), and carotenoid contents (TCC) of bread, as well as their correlation with bread texture and starch digestibility, were investigated. With PF and SPF addition, the peak, breakdown, and setback viscosity of the flour decreased. The addition of PF and SPF reduced the dough formation and stabilization duration, as well as the hardness of the bread. The specific volume of the bread depended on the addition amount of PF and SPF. When the addition of PF and SPF was 15%, the bread had the lowest hardness and highest specific volume. The TPC and TCC in the bread depended on the added flour variety, and negatively influenced specific volume and positively influenced the content of resistant starch (RS).
Purification, antioxidant activities, encapsulation, and release profile of total flavonoids in Peony seed meal
Authors: Zan Lixia , Song Wangting , Wang Weiwei , He Gang , Li Xinsheng , Pei Jinjin 
Published: January 2022

AbstractAs potential biomass resources, biomass waste products have been considered worldwide in recent decades. Peony seed meal (PSM) is a kind of agricultural resource waste containing polyphenols, in particular flavonoids. In this study, the total flavonoids of PSM were extracted and purified by AB‐8 macroporous resin (MR), the antioxidant activities of three extract fractions were evaluated, and the total flavonoids were encapsulated with alginate and chitosan by the complex coacervation method. After purification, the yield of total flavonoids was 11.32% and the content in the product increased to 42.89% ± 2.66. The antioxidant activities of three fractions on ·OH, DPPH, and ABTS assays exhibited the following descending order: ethanol elution fraction (ELF) > ethyl acetate extract fraction (EAF) > ethanol extract fraction (EEF). The single‐factor assay showed that the encapsulated total flavonoid microcapsules (EFMs) were prepared with a chitosan concentration of 10 mg/ml, a sodium alginate concentration of 30 mg/ml, a calcium chloride concentration of 50 mg/ml, a ratio of sodium alginate to total flavonoids of 1:3, a flavonoid concentration of 40 mg/ml, and an encapsulation yield of 80.7%. Most microcapsules are smooth‐faced, spherical and uniform in size ranging from 2 to 3 mm in diameter. In vitro release studies suggested that the EFM was stable at pH 1.2 and dissolved at pH 7.5. The result indicated that the EFM is worthy for the development of functional foods and supplements, and PSM could be a potential resource in the food and pharmaceutical industries.
Profile and determinants of intention to migrate by early career doctors in Nigeria: A report from CHARTING study
Authors: Adeniyi Makinde Adebayo , Efuntoye Oluwafemi , Popoola Gbenga , Adebayo Oladimeji , Ekundayo Oladeji , Ibiyo Morohunmubo , Igbokwe Martin C. , Ogunsuji Oluwaseyi , Fagbule Francis , Egwu Onuwabuchi , Kanmodi Kehinde , Omololu Ayanfe , Soneye Olufunmilayo Y. , Umar Wasinda Francis , Oduyemi Ibiyemi , Egbuchulem Kelvin I. , Amoo Abimbola , Sokomba Aliyu , Kpuduwei Selekeowei Peter Kespi , Olaopa Olusegun 
Published: January 2022

AbstractIntroductionRecently, there has been an upsurge in the migration of medical personnel, especially early career doctors (ECDs) from low‐ and middle‐income countries, Nigeria inclusive, to high‐income countries with wide‐ranging consequences on the social and economic systems of the donor countries. This study assessed the profile and determinants of intention to emigrate by ECDs in Nigeria.MethodsA cross‐sectional study conducted among Nigerian ECDs from nine tertiary hospitals. Socio‐demographic characteristics, intention & reasons to emigrate and willingness to return were collected using a self‐administered semi‐structured questionnaire. Data were analysed using Statistical Package for Social Sciences (SPSS) version 23.ResultsA total number of 763 ECDs participated in the study. The majority (88.2%) were less than 40 years of age and the male to female ratio was 2:1. Majority of the participants (69.4%) received monthly income ≤833 US Dollar. About two‐thirds of ECDs had plans to emigrate and most to developed countries. Common reasons for intention to migrate were better quality of postgraduate training, improved quality of life and better remuneration.ConclusionHigh proportion of Nigerian ECDs has intention to emigrate out with potential adverse effect on the fragile health system in the country.
Rainfall, runoff, and suspended sediment dynamics at the flood event scale in a Loess Plateau watershed, China
Authors: Tian Peng , Feng Jiahao , Zhao Guangju , Gao Peng , Sun Wenyi , Hörmann Georg , Mu Xingmin 
Published: January 2022

AbstractRiver runoff and suspended sediment play a critical role in the chemical, physical, biological processes of Earth's ecosystems. We assessed the temporal changes in runoff and sediment load at both the annual and event scales in the Gushanchuan watershed in the middle reaches of the Yellow River. A total of 330 events, from 1955 to 2018, were selected to evaluate the relationships between rainfall, runoff, and suspended sediment load at the Gaoshiya gauging station. Significant reductions were examined in the maximum runoff peaks, suspended sediment concentration, total runoff, suspended sediment yield, and ratio of event runoff to annual total, whereas the ratio of event sediment yield to annual total remained relatively stable. Hysteresis analysis suggested that the complex loops, anti‐clockwise, and figure‐eight loops accounted for 93.7% of the total events in the watershed. High positive correlations were observed between the flood‐event sediment yield, runoff volume, maximum runoff peaks, and total rainfall amount. The flow‐sediment relationship can be well fitted by the proportional model, and was weaker in 1997–2018 than those in the periods of 1955–1979 and 1980–1996. Runoff during the rising limb of the event significantly contributed to the total runoff and sediment yield. Land use changes and various soil conservation practices were responsible for the decrease in the flood frequency and magnitude. The results of this study provide useful insights into the relationships between rainfall, runoff, and suspended sediment dynamics, and their responses to soil conservation practices.
Streptococcus uberis‐associated mastitis in dairy herds: dealing with outbreaks and improving control
Authors: Sherwin Ginny , Breen James 
Published: January 2022

Background:Streptococcus uberishas been reported to be the most prevalent cause of mastitis in dairy cattle in the UK, incurring a huge cost to the dairy industry each year.Aim of the article: This article informs practitioners about developments in the research ofS uberisand how these findings can be implemented in the field in terms of investigating a herd level outbreak.
Preparation and evaluation of a silk fibroin–polycaprolactone biodegradable biomimetic tracheal scaffold
Authors: Liu Cai‐Sheng , Feng Bo‐Wen , He Shao‐Ru , Liu Yu‐Mei , Chen Liang , Chen Yan‐Ling , Yao Zhi‐Ye , Jian Min‐Qiao 
Published: January 2022

AbstractIn tracheal tissue engineering, the construction of tracheal scaffolds with adequate biodegradable mechanical capacity and biological functions that mimic the structure of a natural trachea is challenging. To explore the feasibility of preparing biomimetic degradable scaffolds with C‐type cartilage rings and an inner tracheal wall of polycaprolactone and silk fibroin. A mold was made according to the diameter of a rabbit trachea, and a silk fibroin tube and polycaprolactone ring attached to the tube were obtained by solution casting. The ring was fixed to the tube at a specific spacing using electrostatic spinning technology to construct a biomimetic tracheal scaffold; its porous structure was observed by scanning electron microscopy, its degradation properties were determined by in vitro enzymatic hydrolysis and its mechanical properties were obtained by pressure testing. The composite scaffold was transplanted subcutaneously into a rabbit model, and the scaffold was taken at 1, 2, and 4 weeks after surgery for sectioning to observe pre‐vascularization. The Medical Ethics Committee of Guangdong Provincial People's Hospital approved the study. The general view of the biomimetic scaffold: the polycaprolactone ring was fixed firmly on the outer wall of the silk fibroin tube; the two corresponded in size, and they fitted closely. The surface of the polycaprolactone ring was smooth and dense, while the surface of the silk fibroin tube could be seen as a uniform porous structure. Scanning electron microscopy showed that the surface and profile of the fibroin tube had a uniform pore size and distribution. The pores were connected to form a network. In vitro, enzymatic hydrolysis experiments confirmed that the fibroin was degraded easily, with most being degraded at the end of week 1. The degradation slowed at 2, 3, and 4 weeks, while the degradation of polycaprolactone was extremely slow. A compression test showed that the compressive resistance of the silk fibroin–polycaprolactone biomimetic scaffolds was much better than that of the rabbit trachea at close thickness. In the tissue staining experiments, as the material degraded, fibrous tissues and blood vessels grew to replace the material, allowing the scaffold to obtain a blood supply and better mechanical properties. A quantitative analysis of CD31 showed that the results for the vascularization of the scaffold were better at 4 weeks than at 2 weeks following subcutaneous grafting (P < .05). The results confirmed that it is feasible to prepare porous, degradable silk fibroin–polycaprolactone biomimetic scaffolds with good mechanical properties and epithelial biological functions by mold casting.