bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel m7G methylation-related miRNA signature for overall survival prediction in thyroid cancer
Authors: Qian Xiaoyu , Tang Jian , Chu Yongquan , Chen Ziqiang , Chen Liang , Shen Chao , Li Lin 
Published: May 2022

Abstract
Background
Thyroid cancer (THCA) is an extremely heterogeneous malignancy with different prognoses.A variety of miRNAs affect the process of tumor through different mechanisms.However, the m7G methylation-related miRNA expression in THCA and their associations with prognostic results remain elusive.
Methods
Based on the miRNA expression data from TCGA, differentially expressed miRNAs were screened out.Then, a 7-miRNA prognostic signature was established through LASSO Cox regression.Eventually, our team performed functional enrichment and immune activity analysis.
Results
A total of 47 differently expressed miRNAs were screened out, 7 of which exhibited a significant correlation with overall survival (OS) (P < 0.05).A 7-miRNA signature was developed, exhibiting an excellent forecast power. Patients were classfied into high- and low-risk groups on the basis of the mid-value of the risk score regarding our signature.The cases in High risk patients displayed a remarkably higher mortality than low risk patients (P < 0.001). The risk scoring was an independent prediction factor for OS based on multivariable Cox regressive analyses (P < 0.05). The receiver operating characteristic(ROC) analyses validated the prediction ability of the signature.Immune activity analyses revealed that the immune status of the two risk groups was different.The differentially expressed genes in the risk score and immune score showed a strong association with immune cells and immune pathways.
Conclusion
A novel miRNA prediction model was established for THCA and these miRNAs could be potential therapeutic targets.
Clinical features and forecast indexes of the disease severity of SARS-CoV-2: a retrospective cohort study comparing the wild-type strain and the Delta VOC
Authors: zhang hongjun , Chen Yue-e , Shang Fen-qing , Chen Yan-wei , Wang Rui-xuan , Zheng Wen-hao , Ma Tian-tian , Zhang Xiu-cheng , Li Wen-jie , Gu Xing 
Published: May 2022

Abstract
Background: A novel variant of SARS-CoV-2, the Delta variant of concern (VOC), on disease severity is very unclear. In this retrospective study, we compared the clinical characteristics and the outcomes of patients infected with the Delta VOC and with wild-type strains during the local outbreak in Xi'an and Wuhan, China.Methods: The clinical information pertaining to the 2927 cases (between February 10 and March 8, 2020) infected with wild-type strains and the 993 cases (between December 22, 2021and February 17, 2022) infected with the Delta VOC were extracted. The clinical characteristics and outcomes were compared the cohort of wild-type infection with the cohort of Delta VOC.Results: Among patients younger than 18 years old, the proportion of patients infected with the Delta VOC was significantly higher than that of patients infected with wild-type strains (12.2% vs. 0.3%). In cases with mild and moderate illness, the proportion of patients was higher in the Delta VOC group than that in the wild-type strain (40.9% and 56.6% vs. 0.70% and 3.10%). However, in severe and critical patients, the proportion of patients was significantly less in the Delta VOC group than that in the wild-type strain (1.6% and 0.9% vs. 24.2% and 72.0%). In cases with severe or critical illness, and in the Delta VOC cohort or the wild-type cohort, the prognosis of patients with lymphocytes blood levels that gradually rising is good after treatment, while the prognosis of patients with lymphocytes blood levels that remain low is poor and even death(p＜0.001). The Cox regression analysis revealed that the infection with the lineage of the wide-type strain had a higher risk than the Delta VOC in deteriorating to critical illness (hazards ratio 2.54[95%CI 1.279-5.026]; p = 0.008). Conclusions: Infection with the Delta VOC is characterized by younger patients, milder illness, and decreased risk of disease prognosis compared with the SARS-CoV-2 wild-type lineage; lymphopenia is an effective predictor of deterioration in patients with Delta VOC and wild-type strains, calling for clinicians to understand of characteristics of them, and to guide clinical decision-making.
Whether Behçet’s patients with large vessel involvement have concurrent small vessel involvement? A Case Control Study
Authors: VOSSOUGHIAN SARA , FAEZI SEYEDEH TAHEREH , SHAHRAM FARHAD , KAVOSI HODA , QORBANI MOSTAFA , NEJADHOSSEINIAN MOHAMMAD , HAERIAN HODA , AHMADZADEH YASAMAN , MOZAFFARI MOHAMMAD ALI , DAVATCHI FEREYDOUN 
Published: May 2022

Abstract
BACKGROUND: Behçet’s disease (BD) is a chronic multisystem disorder. The principal pathological finding in BD is vasculitis, which may involve vessels of different sizes. Concurrence of small and large vessel involvement in BD patients is undetermined. The aim of this study is to evaluate small vessel involvement in BD patients with large vessel involvement.METHODS: 35 BD patients with large vessel involvement (cases) and 35 BD patients without large vessel involvement (controls) were included. For evaluation of small vessel involvement, capillaroscopy was done for all patients. Capillaroscopic findings were compared between two groups. RESULTS: According to the capillaroscopic findings, all of our BD patients had small vessel involvementThe most abnormality was tortuosity (87.1%), followed by avascular areas (51.4%) and decreased density of capillaries (44.2%). Capillaroscopy findings were not statistically different between the case and the control groups. In the case group, the number of avascular areas was associated with superficial phlebitis (p=0.044) and deep vein thrombosis (p= 0.022). In addition, there was a significant association between micro bleeding and the history of erythema nodosum (p=0.015), tortuosity and the history of skin aphthosis (p= 0.015), architectural derangement and the history of uveitis (p=0.029), the number of avascular areas and active oral aphthosis (p= 0.021), and architectural derangement and increased ESR (p=0.011). CONCLUSION: There was no difference in nailfold capillary involvement between BD patients with and without large vessel involvement. However, Among BD patients with large vessel involvement, the number of avascular areas was significantly associated with superficial phlebitis and deep vein thrombosis.
A Nomogram for Predicting Screw Loosening after Single-Level Posterior Lumbar Interbody Fusion utilizing Cortical Bone Trajectory Screw: A Minimum 2-year Follow-up Study
Authors: Zhang Yiqi , Li Yue , Hai Yong , Guan Li , Zhang Xinuo , Pan Aixing , Lu Hongyi , Wu Bingchao , Liu Yuzeng 
Published: May 2022

Abstract
Purpose: To investigate the risk factors for screw loosening after single-level posterior lumbar interbody fusion (PLIF) utilizing cortical bone trajectory (CBT) screw and establish a nomogram for predicting screw looseningMethods: A total of 79 patients (316 screws) underwent single-level PLIF with CBT screw were included in the study. Preoperative, postoperative and final follow-up demographic data, surgical data and radiographic parameters were documented and analyzed to identify risk factors and a predictive nomogram was established for screw loosening. The nomogram was assessed through concordance index (C-index), calibration plot, decision curve analysis (DCA) and internal validation.Results: The incidence of screw loosening was 26.6% in 79 patients, and 11.4% in 316 screws. Multifactorial regression analysis confirmed that fixed to S1 (FS1, OR=3.82, 95%CI 1.12-12.71, P=0.029), coronal angle of the screw (CA, OR=1.07, 95%CI 1.01-1.14, P=0.039) and cortical bone contacted layers (CBCL, OR=0.17, 95%CI 0.10-0.29, P<0.001) were risk factors and incorporated in the nomogram for predicting screw loosening after single-level PLIF with CBT screw. The C-index of the nomogram was 0.877 (95%CI 0.818-0.936) which demonstrated good predictive accuracy. The Calibration plot indicated an acceptable calibration of the nomogram that also had a positive benefit guiding treatment decision. Conclusion: FS1, CA and CBCL are identified to be significant risk factors for screw loosening after single-level PLIF with CBT technique. The nomogram we have established can be used to predict screw loosening and contribute to surgical decision.
Hydrological modelling of climate change impacts in Awash River basin: A case of Borkena River Catchment, Ethiopia
Authors: Kifle Teshome , Ayalew Mamaru , Sahlu Dejena , Sintayehu Gashaw , Belayneh Alemshet 
Published: May 2022

Abstract
Regional and local hydrological regimes are expressively exposed to global climate change, which is considered to be one of the major problems threating water resources and flood security. This research has been done aimed at the examination of the effect of climate change on the hydrology of Borkena watershed, Awash River Basin during 2030s (2021-2040), 2050s (2040-2060), and 2070s (2061-2080) future periods. To realize this, the distributed hydrological SWAT Model driven by three different Global Circulation Models (MIROC5, MPI, and IPSL) under two Representative Concentration Pathway emission scenarios (RCP4.5 and RCP8.5) was used. As result, the GCM projection indicated that, the mean annual maximum and minimum temperature projected to increases by 0.56°c and 0.31°c respectively while the mean annual rainfall has no a significant change in the coming decades. The study also resulted in a considerable average monthly and seasonal, rainfall change in magnitude and direction. Relative to the baseline period the changes in mean annual stream flow from (2021-2080) are mostly negative and indicate a reduction in volume of discharge available in the Borkena river. In addition, trends in the extreme flow are also determined for high and low flows and the results show a forceful negative trend for extreme stream flows and flood volumes may decrease by 43.1% in RCP4.5 under MPI (2021–2040), 38.6% (2041–2060) and 49.4% (2061–2080) in RCP8.5 under IPSL and MIROC5 respectively. These findings will serve as a nearly warning for the alarming extreme weather events for the future period in Borkena watershed as well as Awash River basin which require sustainable and effective adaptive measures for future water resource management.
Entropy detection approach applying random sampling in cognitive radio systems
Authors: Boumaaz Najib , Maali Asmaa , Semlali Hayat , Laafar Sara , Soulmani Abdallah 
Published: May 2022

Abstract
Currently, the spectrum sensing is an active research area in cognitive radio systems that aims to identify the presence or absence of a primary user in a specific frequency band. The challenge of each spectrum sensing technique is to reach a maximum of detection probability for a given false alarm probability and to detect the presence/absence in very low signal to noise ratio regions. In the present work, we endeavor to improve the performance of detection by investigating entropy detection associated with random sampling. The performance of the proposed approach is evaluated in terms of Receiver Operating Characteristic and the reconstruction Signal to Noise Ratio of the detected signal. The obtained results are compared to the uniform sampling case to present the advantages of the random sampling.
Resistance training on body composition aspects of adolescents: ABCD Growth Study
Authors: Dias Jefferson Souza , Agostinete Ricardo Ribeiro , Urban Jacqueline Bexiga , Torres Wésley , Mesquita Eduardo Duarte Lima , Cayres-Santos Suziane Ungari , Chagas Lucas Gabriel Moraes , Lemes Ítalo Ribeiro , Fernandes Rômulo Araújo 
Published: May 2022

Abstract
Background: Resistance training is a known method for weight reduction, but in apparently healthy adolescents the effects on health aspects are not clear. Aims: Was to analyze the relationship between resistance training (RT) and body composition in adolescents over a 12-month follow-up. Methods: Longitudinal study conducted at a public university in Presidente Prudente, SP, Brazil. Data from a study entitled the “ABCD- Growth Study” were used. The sample consisted of 190 adolescents of both sexes from schools (public and private) and sports clubs in Presidente Prudente, Brazil, divided into 3 groups according to RT practice: non-engagement (n=121), irregular engagement (n=44), and frequent engagement (n=25). Engagement in RT was assessed by face-to-face interviews. The bone mineral density (BMD), lean soft tissue (LST), and body fatness (BF) were analyzed using dual-energy x-ray absorptiometry (DXA). All data analyses were performed using BioEstat statistical software (version 5.0) and the statistical significance was set at 5% (p-value <0.05). Results: After 12-months of follow-up, adolescents frequently engaged in RT presented higher gains in LST (6.160 kg [3.727 to 8.593]) and BMD-upper limbs (0.096 g/cm2 [0.072 to 0.121]) when compared to adolescents who were not engaged in RT (2.452 kg [1.461 to 3.442] and 0.096 g/cm2 [0.072 to 0.121], respectively). Findings were more consistent for boys than girls. Conclusion: Regular engagement in RT seems to be related to higher gains in muscle mass and bone density, especially among boys.
Prenatal and postnatal echocardiographic manifestations of early-onset Marfan syndrome: a case report
Authors: Pu Lihong , Wang Yu , Liu Hanmin , Dai Xiaohui , Liu Dan , Wu Ting , Chen Jiao 
Published: May 2022

Abstract
Early-onset Marfan syndrome (eoMFS) is a rare subset of Marfan syndrome with varying phenotypic expression that occurs in the neonatal and infantile periods. eoMFS has a poor prognosis and is associated with high rates of mortality. Most newborn eoMFS patients present with early onset heart failure that is resistant to treatment. However, eoMFS is not easily diagnosed prenatally. This study presents a case of eoMFS in which the patient was assessed to be normal in utero. The patient's developmental process is shown in relatively complete detail.
Live effects of anodal and cathodal transcranial Direct Current Stimulation (tDCS) on glucose metabolism in a patient with chronic hemorrhagic stroke: a PET case study
Authors: Reale Giuseppe , Fusco Augusto , Cocciolillo Fabrizio , Amoruso Vincenza , Glorioso Davide , Calcagni Maria Lucia , Giordano Alessandro , Padua Luca 
Published: May 2022

Abstract
The aim of this study was to assess whether and how tDCS induces acute changes of brain metabolism in a patient with chronic stroke. We studied a patient with chronic right nucleo-capsular hemorrhagic stroke admitted to our Intensive Neurorehabilitation Care. The patient underwent the following protocol: baseline cerebral FDG-PET (T0); cerebral FDG-PET during anodal-tDCS on the affected hemishphere; cerebral FDG-PET during cathodal-tDCS on the unaffected hemisphere. Baseline FDG-PET documented a marked hypomethabolism of the hemorrhagic right nucleo-capsular lesion; T1 FDG-PET showed an increased brain metabolism of both stimulated hemisphere and non-stimulated hemisphere; T2 FDG-PET documented a reduction of metabolism in the hemisphere ipsilateral to the inhibiting current applied by tDCS. The use of PET may unlock new insights on the effects of tDCS on brain metabolism, providing in vivo information about plasticity mechanisms of injured brain. Further studies by using a combination of PET and TDCS are necessary to further clarify the mechanisms of action in relation with the obtained functional outcomes.
Expected Return to Education, Schooling and Child Labour in Cote d’Ivoire
Authors: AHOUAKAN Ehouman Williams Venance 
Published: May 2022

Abstract
The paper attempts to assess whether expected returns to education affect the incidence of child labour in Côte d’Ivoire using the 2008 Households Living Standard Survey (ENV 2008) and the 2013 National Survey on Employment and Child Labour Status (ENSETE 2013). Nationally, approximately a quarter (1/4) of children belonging to the 5 to 17 age group are involved in economic activities. Child labour is a matter of concern in Côte d’Ivoire, as it interferes with schooling. We find evidence that improvement in the expected returns to education leads to regression of the likelihood that both boys and girls be involved in child labour, while it only increases girls’ probability of attending school. This result suggests that households' decisions to provide their children with schooling or to involve them early on in the labour market are sensitive to the expected returns to education. A potential explanation of this could be found in the low expected returns to education. Indeed, many educated people in this country experience difficulties in finding decent jobs. Therefore, sound educational system and labour market reforms likely to improve the return to education could help reduce child labour and improve girls' schooling.
Causes and treatment of temporomandibular luxation – a retrospective analysis of 260 patients
Authors: Tarhio Reetta , Toivari Miika , Snäll Johanna , Uittamo Johanna 
Published: May 2022

Abstract
ObjectivesWe aimed to clarify the aetiology, diagnostic process, and treatment of temporomandibular joint (TMJ) luxation, as the standard care is mainly based on case-reports and systematic studies are lacking. The hypotheses were that luxation occurs spontaneously, recurrence manifests particularly among geriatric patients, and surgery is needed infrequently.Patients and materialsA retrospective study of TMJ luxation patients (n = 260) from 2007 to 2020 was designed and implemented. The primary outcome was type of TMJ luxation (i.e., recurrent or non-recurrent), and secondary outcomes were the need for and type of surgical intervention. Predictor variables comprised age, sex, presence of neurological condition, and mechanism of luxation. Administered treatment and clinical outcomes were recorded.ResultsOf luxation, 61.9% was recurrent and 60.0% due to spontaneous cause. The presence of neurological condition caused a 2.28-fold risk for recurrence of luxation. Only 1.9% of patients underwent surgical intervention. The risk ratio for mortality within 12 months of primary contact was 1.52-fold higher in recurrent luxation patients than in non-recurrent cases.ConclusionsTMJ luxation is often recurrent, bilateral, and spontaneous. Recurrent luxation is associated with geriatric and neurological conditions, and in this group recurrent TMJ luxation predicted death.Clinical relevanceOur findings contribute to more effective diagnostics and treatment of TMJ luxation patients. We show that there is a need to standardize diagnostic measures and treatment patterns. Moreover, collaboration with other specialities, especially neurology and geriatrics, is important.
Total laparoscopic total gastrectomy and distal esophagectomy combined with reconstruction by transhiatal esophagojejunal Roux-en-y mediastinal anastomosis for Siewert II AEG
Authors: Yin Qifan , Zhang Guibin , Qie Peng , Han Shaohui , Liu Lijun 
Published: May 2022

Abstract
Purpose: The optimal procedure is still controversial about Siewert type II AEG, We are attemptto explore the efficacy and feasibility of total laparoscopic total gastrectomy and distal esophagectomy combined with reconstruction by transhiatal esophagojejunal Roux-en-y mediastinal anastomosis for Siewert type II AEG.Method: Data of patients with Siewert type II AEG who received total laparoscopic total gastrectomy and distal esophagectomy combined with reconstruction by transhiatal esophagojejunal Roux-en-y mediastinal anastomosis in the Hebei General Hospital were collected from October 2020 to October 2021, The operation time, surgical blood loss, the number of dissected lymph nodes, duration of drainage tube,the length of stay in ICU, the resume oral feeding time, the length of postoperative hospital stay, postoperative complications and other related indicators of the patients were collected to evaluate the safety and feasibility of this operation.Result: A total of 17 patients received total laparoscopic total gastrectomy and distal esophagectomy combined with reconstruction by transhiatal esophagojejunal Roux-en-y mediastinal anastomosisin the treatment of Siewert type II AEG were analyzed in our research. The mean operation time was 253±24.8min(196-347min); The median surgical blood loss was 250ml(20-2400ml); The average number of dissected lymph nodes were 28±4.6(17-36); The median duration of drainage tube was 5 days(3-7days); The median length of stay in ICU was 18 hours(10-34hours); The median time of resume oral feeding was 6 days(5-7days); The median postoperative hospital stay was 11 days (8-15 days).Among the all enrolled patients, one patient underwent the conversion to laparotomy due to the massive intraoperative bleeding, one patient developed anastomotic stenosis at jejunum side-to-side anastomosis on the first month after surgery, there was no case of death during the operation and postoperative anastomotic fistula. All patients achieved R0 resection with an average distance of 6cm (4-8.5cm) from the upper margin of the tumor to the resection margin.Conclusion: The operation of total laparoscopic total gastric and distal esophagectomy combined with reconstruction by transhiatal esophagojejunal Roux-en-y mediastinal anastomosis is technically feasible and sufficiently safe in the treatment of Seiwert type II AEG from our primary clinical experience.This procedure could be one of the alternatives for the radical treatment of Siewert type II AEG.
A simple nomogram for predicting osteoarthritis severity in patients with knee osteoarthritis
Authors: Zhang Qingzhu , Yao Yinhui , Wang Jinzhu , Chen Yufeng , Ren Dong , Wang Pengcheng 
Published: May 2022

Abstract
Objective: To explore the influencing factors of knee osteoarthritis (KOA) severity and establish a KOA nomogram model.Methods: Inpatient data from our hospital’s Department of Joint Surgery from January 2020-January 2022 were collected, and the least absolute shrinkage and selection operator (LASSO) methods were used to screen the factors for KOA severity to determine the best predictive index. Then, after combining the significant factors from the LASSO and multivariate logistic regressions, a prediction model was established. All potential prediction factors were included in the KOA severity prediction model, and the corresponding nomogram was drawn. The consistency index (C-index), area under the receiver operating characteristic (ROC) curve (AUC), GiViTi calibration band, net classification improvement (NRI) index, and integrated discrimination improvement (IDI) index evaluation of a model predicted KOA severity. Decision curve analysis (DCA) and clinical influence curves were used to study the model’s potential clinical value.Results: Four hundred KOA patients were included. The nomogram’s predictive factors were age, pulse, absolute value of lymphocytes, mean corpuscular haemoglobin concentration (MCHC)and blood urea nitrogen (BUN). The C-index and AUC of the model were 0.802. Giviti calibration band (P = 0.065), NRI (0.091) and IDI (0.033) showed that the modified model can distinguish between severe KOA and nonsevere KOA. DCA showed that the KOA severity nomogram has clinical application value with threshold probabilities between 0.01-0.78.Conclusions: A nomogram model for predicting KOA severity was established for the first time, can visually identify patients with severe KOA, and is novel for indirectly evaluating KOA severity by nonimaging means.