bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural plant diet impacts phenotypic expression of pyrethroid resistance in Anopheles mosquitoes
Authors: Paré Prisca S. L. , Hien Domonbabele F. D. S. , Bayili Koama , Yerbanga Rakiswendé S. , Cohuet Anna , Carrasco David , Guissou Edwige , Gouagna Louis-Clément , Yaméogo Koudraogo B. , Diabaté Abdoulaye , Ignell Rickard , Dabiré Roch K. , Lefèvre Thierry , Gnankiné Olivier 
Published: December 2022

AbstractSuccess in reducing malaria transmission through vector control is threatened by insecticide resistance in mosquitoes. Although the proximal molecular mechanisms and genetic determinants involved are well documented, little is known about the influence of the environment on mosquito resistance to insecticides. The aim of this study was to assess the effect of plant sugar feeding on the response of Anopheles gambiae sensu lato to insecticides. Adults were fed with one of four treatments, namely a 5% glucose control solution, nectariferous flowers of Barleria lupulina, of Cascabela thevetia and a combination of both B. lupulina + C. thevetia. WHO tube tests were performed with 0.05% and 0.5% deltamethrin, and knockdown rate (KD) and the 24 h mosquito mortality were measured. Plant diet significantly influenced mosquito KD rate at both concentrations of deltamethrin. Following exposure to 0.05% deltamethrin, the B. lupulina diet induced a 2.5 fold-increase in mosquito mortality compared to 5% glucose. Species molecular identification confirmed the predominance of An. gambiae (60% of the samples) over An. coluzzii and An. arabiensis in our study area. The kdr mutation L1014F displayed an allelic frequency of 0.75 and was positively associated with increased phenotypic resistance to deltamethrin. Plant diet, particularly B. lupulina, increased the susceptibility of mosquitoes to insecticides. The finding that B. lupulina-fed control individuals (i.e. not exposed to deltamethrin) also displayed increased 24 h mortality suggests that plant-mediated effects may be driven by a direct effect of plant diet on mosquito survival rather than indirect effects through interference with insecticide-resistance mechanisms. Thus, some plant species may weaken mosquitoes, making them less vigorous and more vulnerable to the insecticide. There is a need for further investigation, using a wider range of plant species and insecticides, in combination with other relevant environmental factors, to better understand the expression and evolution of insecticide resistance.
Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach
Authors: Dehghani Mansooreh , Abbasi Alireza , Taherzadeh Ziba , Dehghani Samaneh 
Published: December 2022

AbstractTo monitor employees' work safety and exposure against air contaminants, Trans, trans-muconic acid, Hippuric acid, Methyl hippuric acid, Mandelic acid and Phenylglyoxylic acid can be used as reliable biomarkers of exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) compounds. This study aims to determine the level of urinary metabolites of BTEX compounds using biological monitoring in the employees of a wastewater treatment plant (WWTP) in the south of Iran. The study was performed on 56 employees of the WWTP of one of the southern cities of Iran in 2020. Urine samples (n total = 112) consisting of 60 samples of employees working in the operation section (exposed group) and 52 samples of employees working in the administrative section (control group) in the WWTP were collected before and at the end of their shift. The mean concentration of urinary metabolites of BTEX of both groups ranged from 546.43 (μg/g cr) for trans, trans-muconic acid to 0.006 (μg/g cr) for methyl hippuric acid, which indicates that most of the evaluated metabolites showed a higher concentration than their occupational threshold limit value urine (p < 0.05). Regression analysis results showed a significant correlation (p < 0.05) between age and utilization of flame heaters with changes in the measured BTEX metabolites in the urine. The results of this study illustrate that WWTPs should be considered as one of the workplaces with potential sources of BTEX exposure for employees. Future investigations are recommended to perform itemized appraisals of BTEX intake sources, particularly in employees of the operational sections of WWTP.
Dissociable behavioural signatures of co-existing impulsivity and apathy in decision-making
Authors: Petitet Pierre , Zhao Sijia , Drew Daniel , Manohar Sanjay G. , Husain Masud 
Published: December 2022

AbstractApathy and impulsivity are expressed in a wide range of neuropsychiatric disorders, and, to a less severe extent, in healthy people too. Although traditionally considered to be opposite extremes of a single motivational spectrum, recent epidemiological questionnaire-based data suggest that both traits can in fact co-exist within the same individual. Here, we sought to investigate the relationship between these constructs in healthy people within a controlled task environment that examines the ability to make a decision under temporal uncertainty and measures the vigour of the response. Sixty participants performed a new version of the Traffic Light Task and completed self-report questionnaire measures of apathy and impulsivity. The task required individuals to make rapid decision-making for time-sensitive reward by squeezing a hand-held dynamometer as quickly as possible after a predictable event occurred (a traffic light turning green). Although apathy and impulsivity were positively correlated in questionnaire assessments, the two traits were associated with distinct behavioural signatures on the task. Impulsivity was expressed as an inflexible tendency to generate rapid anticipatory responses, regardless of cost-benefit information. Apathy, on the other hand, was associated with a blunted effect of reward on response vigour. These findings reveal how apathy and impulsivity are related to distinct dimensions of goal-directed behaviour, explaining how these traits might co-exist in the same individuals.
Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis
Authors: Morris Amanda J. , Yau Yvonne C. W. , Park Subin , Eisha Shafinaz , McDonald Nancy , Parsek Matthew R. , Howell P. Lynne , Hoffman Lucas R. , Nguyen Dao , DiGiandomenico Antonio , Rooney Ashley M. , Coburn Bryan , Grana-Miraglia Lucia , Wang Pauline , Guttman David S. , Wozniak Daniel J. , Waters Valerie J. 
Published: December 2022

AbstractWe previously demonstrated that P. aeruginosa isolates that persisted in children with cystic fibrosis (CF) despite inhaled tobramycin treatment had increased anti-Psl antibody binding in vitro compared to those successfully eradicated. We aimed to validate these findings by directly visualizing P. aeruginosa in CF sputum. This was a prospective observational study of children with CF with new-onset P. aeruginosa infection who underwent inhaled tobramycin eradication treatment. Using microbial identification passive clarity technique (MiPACT), P. aeruginosa was visualized in sputum samples obtained before treatment and classified as persistent or eradicated based on outcomes. Pre-treatment isolates were also grown as biofilms in vitro. Of 11 patients enrolled, 4 developed persistent infection and 7 eradicated infection. P. aeruginosa biovolume and the number as well as size of P. aeruginosa aggregates were greater in the sputum of those with persistent compared with eradicated infections (p < 0.01). The amount of Psl antibody binding in sputum was also greater overall (p < 0.05) in samples with increased P. aeruginosa biovolume. When visualized in sputum, P. aeruginosa had a greater biovolume, with more expressed Psl, and formed more numerous, larger aggregates in CF children who failed eradication therapy compared to those who successfully cleared their infection.
Spatial homogeneity pursuit of regression coefficients for hand, foot and mouth disease in Xinjiang Uygur Autonomous Region in 2018
Authors: Zhong Xiaoshuang , Wang Peilin , Zhang Huiguo 
Published: December 2022

AbstractTo explore the complex spatial pattern between the incidence of hand, foot, and mouth disease (HFMD) and meteorological factors [average temperature (AT), average relative humidity (ARH), average air pressure (AP), average wind speed (AW)], this paper constructed a Spatial Clustering coefficient (SCC) regression model to detect spatial clustering patterns of each regression coefficients in different seasons. The results revealed that compared with geographically weighted regression (GWR), the coefficients estimated by SCC method were more smooth with clearly identified spatial and improved edge effects. Therefore, interesting spatial patterns were easy to identify in the SCC estimated coefficients. And then, the SCC method had better estimation accuracy in estimating the relationship between potential meteorological factors and HFMD cases. Meteorological factors had different significance in their effect on HFMD incidence depending on the season. Specifically, the influence of AT on HFMD was negatively correlated in summer and winter, especially in the Altay region, Bayingoleng Mongolian Autonomous Prefecture, Turpan region and Hami region. Second, AW had positive effects with HFMD in summer, but the AW played a negative role in the whole Xinjiang in winter. In Tianshan district, Shayibake district, Shuimogou district, etc. in summer, ARH showed a strong negative correlation, but in Alar city it had a high positive correlation, however, in winter ARH showed a high negative correlation in Altay regions, Aksu region and other places had negative effects, and it showed a strong positive correlation in Shayibak district. Finally, AP had a strong positive correlation with HFMD in summer in Shaybak district, but in winter, AP showed a strong negative correlation in Altay district and Buxel Mongolia Autonomous county. In summary, Xinjiang should adapt measures to local conditions, and formulate appropriate HFMD prevention strategies according to the characteristics of different regions, time, and meteorological factors.
Estimated cost of treating hospitalized COVID-19 patients in Saudi Arabia
Authors: Al Mutair Abbas , Layqah Laila , Alhassan Batool , Alkhalifah Saleh , Almossabeh Modhahir , AlSaleh Thanaa , AlSulaiman Zuhair , Alatiyyah Zainab , Almusalami Eman M. , Al-Jamea Lamiaa H. , Woodman Alexander , Hajissa Khalid , Alhumaid Saad , Rabaan Ali A. 
Published: December 2022

AbstractThe economic impact of the COVID-19 pandemic on global health systems is a major concern. To plan and allocate resources to treat COVID-19 patients and provide insights into the financial sustainability of healthcare systems in fighting the future pandemic, measuring the costs to treat COVID-19 patients is deemed necessary. As such, we conducted a retrospective, real-world observational study to measure the direct medical cost of treating COVID-19 patients at a tertiary care hospital in Saudi Arabia. The analysis was conducted using primary data and a mixed methodology of micro and macro-costing. Between July 2020 and July 2021, 287 patients with confirmed COVID-19 were admitted and their data were analyzed. COVID-19 infection was confirmed by RT-PCR or serologic tests in all the included patients. There were 60 cases of mild to moderate disease, 148 cases of severe disease, and 79 critically ill patients. The cost per case for mild to moderate disease, severe disease, and critically ill was 2003 USD, 14,545 USD, and 20,188 USD, respectively. There was a statistically significant difference in the cost between patients with comorbidities and patients without comorbidities (P-value 0.008). Across patients with and without comorbidities, there was a significant difference in the cost of the bed, laboratory work, treatment medications, and non-pharmaceutical equipment. The cost of treating COVID-19 patients is considered a burden for many countries. More studies from different private and governmental hospitals are needed to compare different study findings for better preparation for the current COVID-19 as well as future pandemics.
Exploration on Quantum Chemical Potential Energy Surfaces
Authors: Ohno Koichi , Satoh Hiroko 
Published: December 2022

Written chemical formulas, such as C2H6O, can tell us the constituent atoms a molecule contains but they cannot differentiate between the possible geometrical arrangements (isomers) of these models. Yet the chemical properties of different isomers can vary hugely. Therefore, to understand the world of chemistry we need to ask what kind of isomers can be produced from a given atomic composition, how are isomers converted into each other, how do they decompose into smaller pieces, and how can they be made from smaller pieces? The answers to these questions will help us to discover new chemistry and new molecules. A potential energy surface (PES) describes a system, such as a molecule, based on geometrical parameters. The mathematical properties of the PES can be used to calculate probable isomer structures as well as how they are formed and how they might behave.
Exploration on Quantum Chemical Potential Energy Surfaces focuses on the PES search based on quantum chemical calculations. It describes how to explore the chemical world on PES, discusses fundamental methods and specific techniques developed for efficient exploration on PES, and demonstrates several examples of the PES search for chemical structures and reaction routes.
Distinct insight into the use of difunctional double-decker silsesquioxanes as building blocks for alternating A–B type macromolecular frameworks
Authors: Duszczak Julia , Mrzygłód Aleksandra , Mituła Katarzyna , Dutkiewicz Michał , Januszewski Rafał , Rzonsowska Monika , Dudziec Beata , Nowicki Marek , Kubicki Maciej 
Published: December 2022

A distinct look at known, hydrosilylation reactions used for the formation of DDSQ-based linear A–B alternating macromolecular systems with DPn > 1000 is presented. Selected physicochemical properties of obtained hybrid co-polymers were determined.
VERTICO
Authors: Jiménez-Donaire María J. , Brown Toby , Wilson Christine D. , Roberts Ian D. , Zabel Nikki , Ellison Sara L. , Thorp Mallory , Villanueva Vicente , Chown Ryan , Bisaria Dhruv , Bolatto Alberto D. , Boselli Alessandro , Catinella Barbara , Chung Aeree , Cortese Luca , Davis Timothy A. , Lagos Claudia D. P. , Lee Bumhyun , Parker Laura C. , Spekkens Kristine , Stevens Adam R. H. , Sun Jiayi 
Published: December 2022

Aims. In this Virgo Environment Traced in CO (VERTICO) science paper, we aim to study how the star formation process depends on the galactic environment and gravitational interactions in the context of galaxy evolution. We explore the scaling relation between the star formation rate surface density (ΣSFR) and the molecular gas surface density (Σmol), also known as the Kennicutt-Schmidt relation, in a subsample of Virgo cluster spiral galaxies.
Methods. We used new Atacama Compact Array and Total Power (ACA+TP) observations from the VERTICO-Atacama Large Millimeter/submillimeter Array (ALMA) Large Program at 720 pc resolution to resolve the molecular gas content, as traced by the 12CO (2 − 1) transition, across the disks of 37 spiral galaxies in the Virgo cluster. In combination with archival UV and IR observations used to determine the star formation rate (SFR), we estimated the parameters of the Kennicutt-Schmidt (KS) relation for the entire ensemble of galaxies, and within individual galaxies.
Results. We find the KS slope for the entire population to be N = 0.97 ± 0.07, with a characteristic molecular gas depletion time of 1.86 Gyr for our full sample, which is in agreement with previous work in isolated, nearby star-forming galaxies. In individual galaxies, we find that the KS slope ranges between 0.69 and 1.40, and that typical star formation efficiencies of molecular gas can vary from galaxy to galaxy by a factor of ∼4. These galaxy-to-galaxy variations account for ∼0.20 dex in scatter in the ensemble KS relation, which is characterized by a 0.42 dex scatter. In addition, we find that the HI-deficient galaxies in the Virgo cluster show a steeper resolved KS relation and lower molecular gas efficiencies than HI-normal cluster galaxies.
Conclusions. While the molecular gas content in galaxies residing in the Virgo cluster appears – to first order – to behave similarly to that in isolated galaxies, our VERTICO sample of galaxies shows that cluster environments play a key role in regulating star formation. The environmental mechanisms affecting the HI galaxy content also have a direct impact on the star formation efficiency of molecular gas in cluster galaxies, leading to longer depletion times in HI-deficient members.
Balint-Psychodrama – Die Bedeutung des Körpers in der
Balint-Arbeit*
Authors: Bachmann Jean-Pierre 
Published: December 2022

ZusammenfassungDer Autor gibt einem kurzen Überblick über den Stellenwert des
Körpers in Freuds Gedanken und die Bedeutung, die Michael Balint dem
Körper in seiner Arbeit als Psychoanalytiker beimaß; dann geht
er der Frage nach, welchen Stellenwert der Körper in der Balint-Arbeit
einnimmt.In den 1970-er Jahren hat die französische Psychoanalytikerin und
Psychodramatikerin Anne Caïn das Balint-Psychodrama entwickelt, eine
Methode, die Balint-Arbeit mit dem psychoanalytischen Psychodrama verbindet. Ein
wesentlicher Aspekt liegt in der Wiedereinführung des Körpers in
die Balint-Arbeit, weshalb sich die Methode hervorragend für die Aus-
und Weiterbildung von Ärzten, Psychologen und Menschen in anderen
helfenden Berufen anbietet.Ein klinisches Beispiel einer Balint-Psychodramasitzung beschreibt diesen Prozess
der Mobilisierung des Körpers, der das Wiederauftauchen eines
verschütteten motorischen Gedächtnisses und das der Affekte
fördert. Das Durchlaufen des psychodramatischen Spiels mit seinen
Rollenwechseln und das Wiedererleben einer rekonstruierten Szene aus dem
Berufsleben fördern die Identifikationsphänomene des Referenten,
die die Grundlage für jedes emotionale Verständnis des Patienten
bilden; sie ermöglichen das Wiederentdecken von
Körpererfahrungen, die an der Gegenübertragung des Referenten
beteiligt sind.
Benefits of Combined MRI Sequences in Meningioma Consistency Prediction: A Prospective Study of 287 Consecutive Patients
Authors: Limpastan Kriengsak , Unsrisong Kittisak , Vaniyapong Tanat , Norasetthada Thunya , Watcharasaksilp Wanarak , Jetjumnong Chumpon 
Published: December 2022

Abstract
Objective Consistency of meningiomas is one of the most important factors affecting the completeness of removal and major risks of meningioma surgery. This study used preoperative magnetic resonance imaging (MRI) sequences in single and in combination to predict meningioma consistency.
Methods The prospective study included 287 intracranial meningiomas operated on by five attending neurosurgeons at Chiang Mai University Hospital from July 2012 through June 2020. The intraoperative consistency was categorized in four grades according to the method of surgical removal and intensity of ultrasonic aspirator, then correlated with preoperative tumor signal intensity pattern on MRI including T1-weighted image, T2-weighted image (T2WI), fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted image (DWI), which were described as hypointensity, isointensity, and hyperintensity signals which were blindly interpreted by one neuroradiologist.
Results Among 287 patients, 29 were male and 258 female. The ages ranged from 22 to 83 years. A total of 189 tumors were situated in the supratentorial space and 98 were in the middle fossa and infratentorial locations. Note that 125 tumors were found to be of soft consistency (grades 1, 2) and 162 tumors of hard consistency (grades 3, 4). Hyperintensity signals on T2WI, FLAIR, and DWI were significantly associated with soft consistency of meningiomas (relative risk [RR] 2.02, 95% confidence interval [CI] 1.35–3.03, p = 0.001, RR 2.19, 95% CI 1.43–3.35, p < 0.001, and RR 1.47, 95% CI 1.02–2.11, p = 0.037, respectively). Further, chance to be soft consistency significantly increased when two and three hyperintensity signals were combined (RR 2.75, 95% CI 1.62–4.65, p ≤ 0.001, RR 2.79, 95% CI 1.58–4.93, p < 0.001, respectively). Hypointensity signals on T2WI, FLAIR, and DWI were significantly associated with hard consistency of meningiomas (RR 1.82, 95% CI 1.18–2.81, p = 0.007, RR 1.80, 95% CI 1.15–2.83, p = 0.010, RR 1.67, 95% CI 1.07–2.59, p = 0.023, respectively) and chance to be hard consistency significantly increased when three hypointensity signals were combined (RR 1.82, 95% CI 1.11–2.97, p = 0.017).
Conclusion T2WI, FLAIR, and DWI hyperintensity signals of the meningiomas was solely significantly associated with soft consistency and predictive value significantly increased when two and three hyperintensity signals were combined. Each of hypointensity signals on T2WI, FLAIR, and DWI was significantly associated with hard consistency of tumors and tendency to be hard consistency significantly increased when hypointensity was found in all three sequences.
Highly crystalline In2S3 thin films epitaxially grown on sapphire substrates
Authors: Jawinski Tanja , Sturm Chris , Clausing Roland , Kempa Heiko , Grundmann Marius , Scheer Roland , von Wenckstern Holger 
Published: December 2022

Indium sulfide (In2S3) thin films were deposited on glass and sapphire substrates by physical co-evaporation of the elements. The deposition parameters were varied to optimize the structural properties of the thin films. The sample epitaxially grown on a-sapphire substrate shows the smoothest surface and the highest crystallinity. The optical absorption properties were found to be independent on the deposition parameters and substrate material. We found for In2S3 a weakly pronounced absorption onset at 1.7 eV and a strong one at 2.5 eV, which can be attributed to direct band–band transitions located at 2.1 and 2.7 eV, respectively. Electrical characterization reveals photovoltaic activity with p-ZnCo2O4/ n-In2S3 heterodiodes but low performance due to non-ideal heterojunction properties. We further find a strong, persistent photoconductivity, which manifests itself in a strong time-dependence of the dark resistivity after the samples were exposed to light.