bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change may cause the extinction of the butterfly Lasiommata petropolitana in the Apennines
Authors: Bonifacino Marco , Pasquali Lorenzo , Sistri Ginevra , Menchetti Mattia , Santini Luca , Corbella Cecília , Bonelli Simona , Balletto Emilio , Vila Roger , Dincă Vlad , Dapporto Leonardo 
Published: April 2022

Abstract
Climate change represents a threat to narrow-ranged mountain species living in low-altitude massifs. We studied the disjunct Apennine population of Lasiommata petropolitana (Lepidoptera, Nymphalidae) in the Gran Sasso and Monti della Laga National Park. We quantified the altitudinal shifts undergone in the last decades (1964-2021) in the Alps and Apennines and estimated the local extinction risk due to climate change. We also sequenced the COI mitochondrial marker of seven Apennine specimens, comparing them with those available across the Palearctic. We projected the probability of presence for the species under a future climatic scenario using an ensemble forecasting approach. We found that, despite geographical isolation, the Apennine population of L. petropolitana displays a single widespread COI haplotype also occurring in most European populations. In the Alps and Apennines, this species has shifted uphill an average of 6.3 m per year since 1964. Accordingly, our model predicted a likely extinction in the Apennines by about 2060, due to a reduction of the climatic suitability in this region. Implications for insect conservation Despite its potential loss in the Apennines would not erode mitochondrial diversity, L. petropolitana characterises the butterfly community of the Gran Sasso massif as an alpine enclave. The loss of the Apennine population, together with those of other orophilous butterflies, could trigger a homogenization of alpha and beta diversity and induce a loss of functional diversity in the impoverished high-altitude biotas. As habitat heterogeneity is a key aspect for populations to endure climate change, the maintenance of varied microhabitats, mainly through grazing management, could address the decline of this population.
Notable Electrical and Mechanical Properties of Polyacrylamide (PAM) with Graphene Oxide (GO) and Single-Walled Carbon Nanotube (SWCNT)
Authors: Awasthi Seema , Yadav Thakur Prasad , Awasthi Kalpana 
Published: April 2022

Abstract
In the present investigations, the Polyacrylamide (PAM)-graphene oxide (GO)-single-walled carbon nanotubes (SWNTs) composite materials has been prepared and physical properties (electrical and mechanical) mesurments have been carried out. The dispersion of GO-SWNTs in PAM matrix was confirmed by scanning electron microscopy. The GO sheets provide the enormous surface area in nanocomposite films, while the SWNTs act as wires joining the GO together in the composite matrix. This interconnected network creates a conducting path, lowering film resistance and improving PAM films' electrical, mechanical, and thermal properties. Raman study demonstrated that carbon nanofiller (SWNTs, GO) and PAM have good interfacial boding. Low-temperature dc electrical conductivity measurement and nanoindentation technique were used to investigate the electrical and mechanical properties of PAM-SWNT-GO composite films. At 15 wt% GO and SWNT loading in PAM, significant increases in electrical conductivity and mechanical characteristics (hardness and elastic modulus) are found. Electrical conductivity of 15 wt% GO and SWNTs in PAM is found to be 5 orders of magnitude higher than that of PAM polymer. In compared to pure PAM polymer, the elastic modulus and hardness are found to be 8 and 134 times higher, respectively.
Takeaways from an Experimental Evaluation of XDP and DPDK under a Cloud Computing Environment
Authors: Freitas Eduardo , Filho Assis T. de Oliveira , Carmo Pedro R. X. , Sadok Djamel H. J. , Kelner Judith 
Published: April 2022

Abstract
The popularization of the Linux kernel at data center servers became a significant factor to consider when developing or deploying network applications. New “packet processing frameworks” emerged to ensure fast packet processing inside these servers that rely on the Linux kernel , XDP and DPDK being the two main ones. Alongside this, Cloud Computing environments dominated the data center scenario, bringing virtualization to the center of these servers. This work compares DPDK and XDP packet processors when subject to a cloud computing environment with I/O, CPU, and network load. We first describe an architecture that implements frameworks and emulates a cloud environment. We measure throughput and packet loss while varying the number of competing VMs, CPU usage by the frameworks, and packet size and present our results in the form of takeaways. We conclude that the virtual environment can impact the performance of both frameworks depending on the received packet size and the type of workload the cloud environment performs. A significant case to highlight is when the cloud environment performs network load, and the servers receive small-sized packets, creating both throughput degradation and increasing packet loss. We conclude our experiments by conducting statistical non-parametric hypothesis tests to enhance our conclusions and have a closer look at the results.
Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk
Authors: Shao Xin , Li Chengyu , Yang Haihong , Lu Xiaoyan , Liao Jie , Qian Jingyang , Wang Kai , Cheng Junyun , Yang Penghui , Chen Huajun , Xu Xiao , Fan Xiaohui 
Published: April 2022

Abstract
Spatially resolved transcriptomics (ST) provides genetic information in space toward elucidation of the spatial architecture in intact organs and the spatially resolved cell-cell communications mediating tissue homeostasis, development, and disease. To facilitate inference of spatially resolved cell-cell communications from ST data, we here present SpaTalk, which relies on a graph network and knowledge graph to model and score the ligand-receptor-target signaling network between spatially proximal cells, decomposed from ST data through a non-negative linear model and spatial mapping between single-cell RNA-sequencing and ST data. The performance of SpaTalk benchmarked on public single-cell ST datasets was superior to that of existing cell-cell communication inference methods. SpaTalk was then applied to STARmap, Slide-seq, and 10X Visium data, revealing the in-depth communicative mechanisms underlying normal and disease tissues with spatial structure. SpaTalk can uncover spatially resolved cell-cell communications for single-cell and spot-based ST data universally, providing new insights into spatial inter-cellular dynamics.
Efficacy and safety analysis of a new hemostatic gelatin matrix for spinal surgery: A randomized controlled study
Authors: Gao Ran , Yang Xiaowei , Xu Jiaqiang , Liang Wen , Xie Banglin , Zhang Bin , Guo Runsheng , Lai Qi 
Published: April 2022

Abstract
Objective: This study aimed to assess the efficacy and safety of a new hemostatic gelatin matrix for use in spinal surgery.Methods: From September to December 2020, 54 patients from our hospital were recruited and randomly allocated to a test group or a control group using computer-generated randomization codes. In the test group, the new hemostatic gelatin matrix was used; in the control group, the Surgiflo™ Hemostatic Matrix was used. All operations for both groups were performed by a senior physician, and the following measures were recorded for comparison: (i) rates of successful hemostasis at 5 min; (ii) time to hemostasis; (iii) blood pressure (BP); (iv) red blood (RBC) cell count; and (v) hemoglobin (Hb) levels in the preoperative period, 1st to 2nd postoperative days, and 42nd postoperative day. Adverse events following surgery were also compared. Results: All patients were followed up for at least 6 weeks. In the test group, 24 and 2 cases achieved and did not achieve hemostasis within 5 min, respectively. In the control group, 23 and 2 cases achieved and did not achieve hemostasis within 5 min, respectively. There was no statistical difference between the two groups (P = 0.967). The time to hemostasis, BP, RBC, and Hb in the preoperative period, on the 1st and 2nd postoperative days, and 42nd postoperative day also showed no significant differences between groups (P > 0.05).Conclusion: The new hemostatic gelatin matrix has the same efficacy and safety as that of Surgiflo™ Hemostatic Matrix.
Metastasis of nasopharyngeal carcinoma to the brain: a case report and literature review
Authors: Sun Junwei , Li Jianhua , Wang Mingyu , Kan Zhisheng 
Published: April 2022

Abstract
Background:Nasopharyngeal carcinoma (NPC) is one of the most common tumors in the head and neck. Brain metastasis from NPC is extremely rare and few case reports describe it in detail. Case presentation: We presented the experience of a 51-year-old patient with NPC that progressed to brain metastases and was surgically removed. The primary lesion of NPC was located in his left pharynx, while the metastatic mass appeared in the right temporal lobe, and it caused significant space-occupying effects. Surgical resection was performed and histopathology after surgery confirmed that the mass was a non-keratinizing undifferentiated carcinoma. Conclusions:Clinicians should pay continuous attention to the occurrence of NPC brain metastasis. More studies should focus on the epidemiological characteristics, the mechanisms of metastasis, advanced diagnostic methods, and better treatment strategies for NPC brain metastases.
Comparison of outcomes between Oblique Lumbar Interbody Fusion and MED-Assisted Minimally Invasive Transforaminal Lumbar Interbody Fusion in single-level lumbar spondylosis
Authors: Chang Feng , Wei Jinpeng , Zhang Peng , Gao Gang , Zhang Ting , Yu Chen , Xu Yongli , Ge Yizhou , Zhang Zhiguo , Huang Ying 
Published: April 2022

Abstract
Background: For Lumbar degenerative spondylolisthesis, lumbar fusion surgery is usually one of the treatment options after conservative treatment has failed. This retrospective study compared the recent clinical efficacy of Oblique Lumbar interbody Fusion (OLIF) and Microendoscopic Discectomy combine Minimally Invasive Transforaminal Lumbar Interbody Fusion (MED-assisted MIS-TLIF) in the treatment of lumbar single-level spondylolisthesis. Methods: A total of 55 patients with degenerative lumbar spondylolisthesis who underwent OLIF or MED-assisted MIS-TLIF between February 2019 and February 2021 were enrolled. Operating time, intra-operative bleeding and post-operative drainage were recorded to evaluate the intraoperative performance. The oswestry disability index (ODI) and visual analog scale (VAS) for back and leg pain were used to evaluate the clinical outcomes. Lumbar lordosis (LL), fused segmental lordosis (FSL) and disc height (DH) were measured preoperatively, three days postoperatively, 3 months and 12 months postoperatively. Fusion status (FS) and cage subsidence (CS) were assessed at final follow-up postoperatively. Results were analyzed statistically.Results: In this study, patients were divided into the OLIF group (35 cases) and the MIS-TLIF group (20 cases). No statistically significant difference in preoperative indicators between groups. Intraoperative performance of the OLIF group was better than that of the MIS-TLIF group. At the immediate postoperative, the VAS was 3.54±1.12 in the OLIF group and 4.25±1.02 in the MIS-TLIF group(P=0.024). There was no significant difference in the VAS and ODI score at subsequent follow-up. Comparison of radiographic indicators showed that there was a significant difference in the DH between groups at post-operative and final follow-up(12.11±1.83 mm vs 11.04±1.26 mm, P = 0.024; 11.98±1.81 mm vs 10.88±1.27 mm, P =0.011). At the last follow-up, the fusion rate and CS in the OLIF group and the MIS-TLIF group was not statistically significant (91.43% vs 75%, P=0.206; 8.57% vs 15%, P=0.775).Conclusion: OLIF has advantages in terms of intraoperative performance and postoperative recovery. In terms of clinical presentation, both two groups have excellent short-term outcomes for patients with lumbar spondylolisthesis. Further follow up is required for long term outcome.
Intratracheal trimerized nanobody cocktail protects against SARS-CoV-2 Omicron in mice
Authors: Nagata Kayoko , Utsumi Daichi , Asaka Masamitsu , Maeda Ryota , Shirakawa Kotaro , Kazuma Yasuhiro , Nomura Ryosuke , Horisawa Yoshihito , Yanagida Yohei , Kawai Yugo , Sato Kei , Yamaoka Yutaro , Miyakawa Kei , Ryo Akihide , Yasutomi Yasuhiro , Imura Akihiro , Takaori-Kondo Akifumi 
Published: April 2022

Abstract
SARS-CoV-2 Omicron variants are highly resistant to vaccine-induced immunity and human monoclonal antibodies. Here, we demonstrate that a novel nanobody TP86 potently neutralized both BA.1 and BA.2 Omicron variants, and that the TP17 and TP86 nanobody cocktail broadly neutralized in vitro all VOCs as well as D614G. Furthermore, this cocktail showed therapeutic efficacy in vivo on VOCs using human ACE2 transgenic mice.
Survival outcomes of patients with FIGO stage IV ovarian cancer: cytoreduction still matters
Authors: Xiao Yao , Linghu Hua 
Published: April 2022

Abstract
Purpose: There is still no consensus on the therapeutic strategies for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IV ovarian cancer (OC). We aim to outline the clinical characteristics and optimal therapeutic strategies of patients with FIGO stage IV OC.Methods: This retrospective study analyzed the clinical features and survival of patients with FIGO stage IV OC that underwent cytoreduction or received at least one course of chemotherapy between January 2014 and December 2020.Results: One hundred and twenty patients were included. Compared with chemotherapy alone, cytoreduction significantly improved the median overall survival of patients (51 months vs. 21 months, p<0.001, HR 2.43, 95% CI 1.11-5.33). The completion of chemotherapy improved median overall survival of patients either with (53 months vs. 25 months, p<0.001, HR 7.015, 95% CI 1.372-35.881) or without cytoreduction (43 months vs. 6 months, p=0.006, HR 5.969, 95% CI 1.115-31.952). In patients with FIGO stage IVB, those with only extra-abdominal lymph node metastases had better survival. Conclusions: In patients with FIGO stage IVB, those with only extra-abdominal lymph node metastases had a better prognosis. Cytoreduction provided survival benefits to patients with FIGO stage IV OC. Completion of chemotherapy improved survival of patients either with or without surgery.
PENGARUH BEBAN KERJA DAN GAJI TERHADAP KINERJA PT CIOMAS ADISATWA LAMPUNG SELATAN
Authors: Sari Rani Puspita , Citra Welia , Sanjaya Vicky F 
Published: April 2022

Abstrak: Penelitian ini memiliki tujuan untuk mengetahui dampak dari adanya beban kerja dan gaji terhadap kinerja karyawan pada PT Ciomas Adisatwa Lampung Selatan. Penelitian ini menggunakan metode penelitian kuantitatif, dengan 30 responden yang dikumpulkan dari karyawan PT Ciomas Adisatwa Lampung Selatan dengan teknik analisis data menggunakan PLS. Hasil yang diperoleh dari penelitian ini adalah variabel beban kerja dan gaji terbukti memiliki pengaruh secara signifikan terhadap kinerja karyawan. Oleh karena itu, PT Ciomas Adisatwa Lampung Selatan harus menjadikan beban kerja dan gaji sebagai salah satu tolak ukur utama dalam meningkatkan kinerja perusahaan.
Kata Kunci: Beban Kerja; Gaji; Kinerja

Abstract: This study aims to determine the impact of workload and salary on employee performance at PT Ciomas Adisatwa South Lampung. In this study using quantitative research methods, with 30 respondents collected from employees of PT Ciomas Adisatwa Lampung Selatan with data analysis techniques using PLS. The results obtained from this study are that the workload and salary variables have been shown to have a significant influence, therefore PT Ciomas Adisatwa Lampung Selatan must make workload and salary as one of the main benchmarks in improving company performance.
Keywords: Workload; Salary; Performan
STRATEGI SOSIAL, EKONOMI, DAN BUDAYA PEKERJA PURNA MIGRAN ERA PANDEMI COVID-19
Authors: Agustina Ika , Mubarok Kasirul 
Published: April 2022

Abstrak: Masyarakat di era COVID-19 mengalami perubahan, tak terkecuali purna migran. Perubahan terjadi yang disebabkan oleh pandemi mengakibatkan purna migran membuat dan melaksanakan strategi dalam bidang sosial, ekonomi, dan budaya untuk mempertahankan hidup. Tujuan dari penelitian ini adalah untuk menjelaskan bagaimana strategi sosial, budaya, dan ekonomi purna migran dalam masyarakat pada era pandemi. Teori Tindakan Sosial, Teori Masyarakat Risiko, dan Teori Modal Sosial digunakan sebagai alat untuk memperkuat analisis. Metode yang digunakan adalah kualitatif dengan pendekatan studi kasus terhadap strategi sosial, budaya, dan ekonomi pekerja purna migran dalam masyarakat masa pandemi kemudian dengan melakukan wawancara mendalam kepada empat informan purna pekerja migran. Hasil penelitian menunjukkan saat awal menjadi purna migran mereka mengalami risiko akibat pandemi (diberhentikan, dipulangkan, dan tidak dibayar). Untuk memenuhi kebutuhan hidup, mereka membuat strategi dalam bidang sosial, budaya, dan ekonomi merupakan pilihan yang tepat dan modal yang dimiliki purna migran dapat dikembangkan, baik sosial, budaya, dan ekonomi. Temuan menarik dalam penelitian ini adalah setelah menjadi purna migran yang sudah menerapkan strategi mereka tetap mengalami risiko dalam bidang tersebut sesuai dengan teori masyarakat risiko.
Kata Kunci : Strategi Sosial; Strategi Ekonomi; Strategi Budaya; Purna Pekerja Migran.

Abstract: Society in the COVID-19 era has changed, including post-migrants. The changes that have occurred due to the pandemic have resulted in returning migrants to create and implement strategies in the social, economic, and cultural fields to sustain life. The purpose of this study is to explain how the social, cultural, and economic strategies of post-migrants in society during the pandemic era. Social Action Theory, Community Risk Theory, and Social Capital Theory are used as tools to strengthen the analysis. The method used is qualitative with a case study approach to the social, cultural, and economic strategies of returning migrant workers in a community during the pandemic and then conducting in-depth interviews with four informants of returning migrant workers. The results showed that when they first became retired migrants, they were at risk due to the pandemic (dismissed, repatriated, and unpaid). To meet the needs of life, they make a strategy in the social, cultural, and economic fields which is the right choice and the capital owned by post-migrants can be developed, both socially, culturally, and economically. An interesting finding in this study is that after returning migrants who have implemented the strategy, they still experience risks in this field according to the risk society theory.
Keywords: Social Strategy, Economic Strategy, Cultural Strategy, Retired Migrant Workers.
FATORES SOCIODEMOGRÁFICOS E CLÍNICOS ASSOCIADOS AO ATENDIMENTO DE IDOSOS VÍTIMAS DE QUEDAS EM UM PRONTO-SOCORRO
Authors: Martins Cristiano Inácio , Rona da Silva Karla , Castro Santos Camargos Mirela 
Published: April 2022

Introdução: Com o envelhecimento populacional e aumento da longevidade, é de se esperar um aumento na demanda por atendimento dessa população, por diversos motivos, entre eles as quedas. Objetivo: Analisar os fatores sociodemográficos e clínicos associados à atendimentos por quedas em pacientes idosos de um pronto-socorro referência para politraumatizado do Estado de Minas Gerais. Metodologia: Estudo transversal descritivo, de natureza quantitativa, coleta de dados em fontes secundária. Resultados: A análise demonstrou maiores chances de ocorrência de queda no sexo feminino, um paciente de 75 a 79 anos tem 1,2 vezes mais chances de sofrer queda em comparação a um paciente na faixa de 60 a 64 anos. Estas chances são aumentadas em 1,5 vezes se o paciente for da faixa de 80 a 84 anos, 2,0 vezes se for da faixa de 85 a 89 anos, 2,5 vezes se for da faixa de 90 a 94 anos, 3,4 vezes se for da faixa de 95 a 99 anos e 6,5 vezes se for da faixa de 100 anos ou mais. Um paciente com classificação de Manchester verde tem 2,7 vezes mais chances de sofrer queda em comparação a um paciente com classificação azul. Estas chances são aumentadas 4,8 vezes para o paciente classificado na cor amarela, aumento de 6,4 vezes para a classificação cor laranja e 3,3 vezes para a cor vermelha. As lesões em membros inferiores foram os mais prevalentes dentre as lesões corporais. Considerações Finais: Os resultados apresentados são insumos para o planejamento de ações necessárias a gestão e organização da atenção à saúde do idoso, que contribuem para o fortalecimento de uma assistência de qualidade, segura e transparente.
Palavras-chave: Idoso. Quedas. Pronto-socorro.
Impact of climate change on streamflow of Melka Wakena catchment, Upper Wabi Shebelle sub-basin, south-eastern Ethiopia
Authors: Fita Teshale , Abate Brook 
Published: April 2022

Abstract
Climate change is becoming a global concern, dictating the water resource availability of a certain region. This study focuses on the impact of climate change on the streamflow of the Melka Wakena reservoir in the Upper Wabi Shebelle sub-basin using a Soil Water Analysis Tool (SWAT). The climate model variables (precipitation and temperature) are obtained from the Coordinated Regional Downscaling Experiment (CORDEX-Africa) and applied under representative concentration pathway (RCP4.5) and (RCP8.5) scenarios. Bias correction was applied to the climate variables before transferring to the hydrological model (SWAT) to simulate discharge. The performance measures R2, NSE, and Percent Bias (PBIAS) for calibration and validation were 0.69, 0.65, and −5.10 and 0.65, 0.61, and −9.81, respectively. Streamflow was simulated for two consecutive periods from 2021 to 2050 and from 2051 to 2080 for both scenarios and compared with the base period from 1986 to 2015 to explore the impact of climate change on inflows to the reservoir. The result obtained showed that the precipitation was predicted to be mildly decreasing, whereas overall annual flow was projected to be insignificantly decreasing under RCP4.5 and RCP8.5 scenarios. The impact of climate change on the water resource of the study area was predicted to be a statistically insignificant reduction.
Study on optimization of coagulation-flocculation of fish market wastewater using bittern coagulant – response surface methodological approach
Authors: Bagastyo Arseto Yekti , Anggrainy Anita Dwi , Gatneh Syaima , Nurhayati Ervin , Susanti Diah , Widodo Erwin , Soehartanto Totok , Warmadewanthi IDAA 
Published: April 2022

Abstract
Bittern contains a high ionic strength that can be used as an alternative coagulant in wastewater treatment. The magnesium content in the bittern could promote the removal of suspended particles and nutrients as settleable precipitates. This would create a more compact and manageable sludge. This study investigates the performance of bittern as a coagulant for fish market wastewater treatment. The effectiveness of bittern was evaluated based on the efficiency of pollutants removal and the amount of residual magnesium. The experiments were performed using a standard jar test. Response surface methodology (RSM) based on a two-factor central composite design (CCD) was used to design the experiment. The parameters involved were pH (7.5, 9, and 10.5) and coagulant dose (0.5, 1.5, 2.5 mL L−1). The maximum removal efficiencies (i.e., 93.3% TSS, 87.5% COD, 37.6% ammonium, and 91.3% phosphate) were recorded at pH 10.5 and 1.5 mL L−1 dose of bittern, while the optimum results (desirability value of 0.929) may occur at pH 10.5 and a dose of 1.284 mL L−1. Approximately 51% of struvite and 48% of calcite precipitates were identified in the generated sludge, which can possibly be used as supplementary material in agrochemical industry with further treatment.