bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of perceived government corruption on depressive symptoms with social status as a moderator
Authors: Zhang Yujie 
Published: December 2022

AbstractPerceived government corruption is an important indicator of depressive symptoms. Recent studies have explored the relationship between perceived government corruption and depressive symptoms in a cross-cultural context, but the underlying mechanisms need further research. This paper examines the impact of perceived government corruption on depressive symptoms in China and the moderating role of social status. Based on the 2018 wave of China Family Panel Studies (CFPS2018), 14,116 respondents aged between 16 and 96 were selected. The results revealed: (1) Perceived government corruption was significantly positively correlated with depressive symptoms. (2) Social class had an inhibitory effect in moderating the relationship between perceived government corruption and depressive symptoms. (3) The moderating effect was only significant for respondents who received education between junior high school and a bachelor’s degree. The findings provide policy implications for developing countries and transitional societies like China. To build a more psychologically healthy society, we need to strengthen anti-corruption, stimulate social mobility, and improve people's sense of gain in the future
Prediction method of cutting stability of roadheader based on the Newton–Lagrange mixed discrete method
Authors: Zhu Yun , Xie Miao , Wang He 
Published: December 2022

AbstractIn order to study the influence of the multiple interaction of coal and rock and the velocity effect of the cutting head on the flutter stability of the cantilever roadheader, considering the physical characteristics of coal and rock, the structural parameters of the cutting head and the motion parameters of the cutting head, the functional expression of the cutting depth of the cutting head and the participating cutting teeth is fitted, the cutting state mechanical characteristic equation of the dynamic cutting of the cutting teeth is established, and based on the mapping relationship between the cutting teeth and the cutting head, a cutting dynamic model including multiple interactions between cutting head and coal and rock and the speed effect is constructed. An improved discrete method based on Newton–Lagrange mixed interpolation is proposed, and the influence law of the coupling effect of regeneration effect and velocity effect on the stability of cutting flutter under cutting state is clarified. The improved full discrete method is compared with the full discrete method and the semi-discrete method, and the superiority of the improved full discrete method based on the mixed interpolation method is proved. Based on the improved total discrete method, the influence of different cutting system dynamic parameters on the stability is studied. A cutting head coal rock system is built to simulate the flutter of the cutting system. The results show that the improved fully discrete method can reasonably predict the actual cutting state.
Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy
Authors: Manzano-Muñoz Albert , Yeste José , Ortega María A. , Martín Fernando , López Anna , Rosell Jordi , Castro Sandra , Serrano César , Samitier Josep , Ramón-Azcón Javier , Montero Joan 
Published: December 2022

AbstractPrecision medicine is starting to incorporate functional assays to evaluate anticancer agents on patient-isolated tissues or cells to select for the most effective. Among these new technologies, dynamic BH3 profiling (DBP) has emerged and extensively been used to predict treatment efficacy in different types of cancer. DBP uses synthetic BH3 peptides to measure early apoptotic events (‘priming’) and anticipate therapy-induced cell death leading to tumor elimination. This predictive functional assay presents multiple advantages but a critical limitation: the cell number requirement, that limits drug screening on patient samples, especially in solid tumors. To solve this problem, we developed an innovative microfluidic-based DBP (µDBP) device that overcomes tissue limitations on primary samples. We used microfluidic chips to generate a gradient of BIM BH3 peptide, compared it with the standard flow cytometry based DBP, and tested different anticancer treatments. We first examined this new technology’s predictive capacity using gastrointestinal stromal tumor (GIST) cell lines, by comparing imatinib sensitive and resistant cells, and we could detect differences in apoptotic priming and anticipate cytotoxicity. We then validated µDBP on a refractory GIST patient sample and identified that the combination of dactolisib and venetoclax increased apoptotic priming. In summary, this new technology could represent an important advance for precision medicine by providing a fast, easy-to-use and scalable microfluidic device to perform DBP in situ as a routine assay to identify the best treatment for cancer patients.
Performance enhancement of arrayed waveguide grating‐based fibre Bragg grating interrogation assisted by random forest
Authors: Yue Zizheng , Li Wenbo , Zheng Di , Xie Changjian , Pan Wei , Zou Xihua 
Published: December 2022

AbstractThe random forest, a powerful machine learning algorithm, is introduced to improve the performance of silicon arrayed waveguide grating (AWG)‐based fibre Bragg grating (FBG) wavelength interrogation. The experimental results show the proposed method has high interrogation accuracy with the root mean squared error (RMSE) of 0.73 pm in the whole demodulation range.
Experimental study on the transition process from partial discharge to arc discharge of oil–paper insulation based on fibre‐optic sensors
Authors: Zhang Zhixian , Chen Weigen , Li Zhengqi , Du Lin , Jiang Tianyan , Cai Nini , Song Ruimin , Li Meng , Wang Jianxin , Wang Ziyi 
Published: December 2022

AbstractArc discharge in the power transformer can bring enormous economic losses and safety risks. The transformer protection system for arc discharge faults is still not ideal. The physical characteristics of the whole process from partial discharge defects transition to arc faults are not fully recognized, mainly because it is difficult to establish and sense the relevant characteristic parameters. This paper built a research platform for studying the transition process from partial discharge to early arc discharge based on fibre‐optic ultrasonic, temperature, pressure sensors with traditional electrical voltage and current sensors. Five discharge models are designed and the changing pattern of multiple parameters in the transition process of different models is studied. The experiment results show that the amplitude and frequency of acoustic waves drop significantly after the arc breakdown. Ultrasonic and high‐frequency current sensing in the early warning of arc fault each has its own limitations. The pressure caused by the arc is not only related to the arc energy but also related to the discharge types. The overall oil temperature change after the early arc discharge is small and hard to detect. This work highlights the promise of using fibre‐optic sensors for physical process research within a harsh electromagnetic environment.
« Une terre irriguée est une terre à riz » : impacts des politiques rizicoles sur la sécurité foncière des petits agriculteurs de Birmanie, de la colonisation à nos jours
Authors: Boutry Maxime 
Published: December 2022

Bien qu’il n’existe pas à proprement parler de régime différencié concernant le foncier irrigué en Birmanie, le développement de l’irrigation se confond dans la majorité des cas avec le développement de la riziculture inondée, et en ce sens génère des enjeux fonciers qui lui sont propres. L’étude du rapport des pouvoirs birmans pré- et postcoloniaux à l’irrigation permet de mettre en exergue la continuité symbolique et politique de la relation entre maîtrise de l’irrigation à des fins de riziculture et construction étatique. L’intervention des gouvernements postcoloniaux en matière d’irrigation peut être caractérisée d’une part en politiques de contrôle dans les plaines centrales et dans le delta de l’Irrawaddy, et en politiques d’ordre « civilisatrices » dans les régions montagneuses d’autre part. Bien que de natures différentes, les formes d’insécurité foncière liées à la culture de terres irriguées n’en sont pas moins une constante. Dans les régions de plus fort contrôle de l’État (c’est-à-dire dans les grands périmètres irrigués des plaines et du delta), la sécurité foncière qui pourrait théoriquement découler de régimes fonciers stables a en réalité été systématiquement sapée par les contraintes économiques imposées dans un objectif d’accroissement de la productivité pour l’État et au détriment des petits agriculteurs. Dans les hautes terres, l’introduction de programmes de culture du riz irrigué a profondément bouleversé les régimes fonciers coutumiers et conduit à la captation des terres les plus fertiles par une élite.
Is the (Neo)adjuvant Therapy of Patients with Primary HER2-positive Breast Cancer Cost-Covering?
Authors: Krawczyk Natalia , Ruckhäberle Eugen , Lux Michael Patrick , Fehm Tanja , Greiling Michael , Osygus Michael 
Published: December 2022

Abstract
Introduction HER2 positivity is one of the most important predictive factors in the treatment of breast cancer patients. Thanks to new targeted anti-HER2 drugs, the prognosis for HER2-positive breast cancer patients has been significantly improved, and the treatment can now be designed according to the risk situation and the response to treatment. At the same time, these innovative targeted anti-HER2 drugs are associated with high costs and require long and involved patient care.
Materials and Methods In this paper, we compare the treatment costs of three post-neoadjuvant treatment regimens (trastuzumab vs. trastuzumab/pertuzumab vs. T-DM1) in early stage HER2-positive breast cancer from the perspective of the oncological outpatient clinic of a certified breast center at a university hospital, and evaluate the cost coverage.
Results The highest costs in systemic therapy were the material costs. These were the highest for dual blockade with trastuzumab/pertuzumab, followed by T-DM1 and trastuzumab monotherapy. According to our study, all three of these post-neoadjuvant therapy variants achieve a positive contribution margin. While all three models have similar contribution margins, the treatment pathway with T-DM1 is associated with a 30% lower contribution margin.
Conclusions Although these model calculations are associated with limitations in view of the introduction of biosimilar antibodies, it can be shown that modern therapeutic approaches do not always have to be associated with lower profits.
Das Jerusalem-Syndrom
Authors: Bernhard Pajonk Frank-Gerald , Juckel Georg , Mavrogiorgou Paraskevi 
Published: December 2022

ZUSAMMENFASSUNGJerusalem ist Sehnsuchtsort dreier Weltreligionen. Nirgendwo sonst kommt es so häufig zu psychotischen Erkrankungen mit religiösen Inhalten, man spricht vom Jerusalem-Syndrom. Die Ätiologie und der Verlauf sind heterogen. Vom Jerusalem-Syndrom in seiner reinen Form sind Touristen ohne psychiatrische Vorerkrankungen betroffen. Es handelt sich überwiegend um weiße Protestanten, die sich zunehmend aus ihrer Reisegruppe zurückziehen, sich mit einer religiösen Figur aus dem Alten oder Neuen Testament identifizieren und verhaltensauffällig werden. Im vorliegenden Beitrag werden der historische Hintergrund, die Häufigkeit, Risikofaktoren, differenzialdiagnostische Überlegungen und insbesondere psychodynamische Erklärungsmodelle sowie der Verlauf und die Therapie dargestellt.
SEPRES: Intensive Care Unit Clinical Data Integration System to Predict Sepsis
Authors: Chen Qiyu , Li Ranran , Lin ChihChe , Lai Chiming , Huang Yaling , Lu Wenlian , Li Lei 
Published: December 2022

Abstract
Background The lack of information interoperability between different devices and systems in the intensive care unit (ICU) hinders further utilization of data, especially for early warning of specific diseases in the ICU.
Objectives We aimed to establish a data integration system. Based on this system, the sepsis prediction module was added to compose the Sepsis PREdiction System (SEPRES), where real-time early warning of sepsis can be implemented at the bedside in the ICU.
Methods Data are collected from bedside devices through the integration hub and uploaded to the integration system through the local area network. The data integration system was designed to integrate vital signs data, laboratory data, ventilator data, demographic data, pharmacy data, nursing data, etc. from multiple medical devices and systems. It integrates, standardizes, and stores information, making the real-time inference of the early warning module possible. The built-in sepsis early warning module can detect the onset of sepsis within 5 hours preceding at most.
Results Our data integration system has already been deployed in Ruijin Hospital, confirming the feasibility of our system.
Conclusion We highlight that SEPRES has the potential to improve ICU management by helping medical practitioners identify at-sepsis-risk patients and prepare for timely diagnosis and intervention.
A Review on Application of Poly(3,4-ethylenedioxythiophene) (PEDOT) in Rechargeable Batteries
Authors: Su Laisuo , Kumar Shwetha Sunil , Manthiram Arumugam , Reeja-Jayan B. 
Published: December 2022

Since the very first patent on poly(3,4-ethylenedioxythiophene) (PEDOT) that was filed in 1988, this polymer has been widely utilized and has achieved great success owing to its high electrical conductivity and excellent stability. The application of the conducting polymer, PEDOT, in renewable energy devices, especially rechargeable batteries, is attracting increasing attention due to its potential to solve the energy and climate crisis. In this review, we summarize the research over the past few decades directed toward the application of PEDOT in rechargeable batteries aimed at improving their electrochemical performance. We focus on PEDOT synthesized via oxidative chemical vapor deposition (oCVD), a relatively new process known for its ability to grow conducting polymer thin films with uniform, pinhole-free properties, and controllable thickness and conformality. For a comparison purpose, PEDOT synthesized via solution-based methods is also briefly summarized. Finally, future research directions for applying oCVD PEDOT in rechargeable batteries are discussed.IntroductionPEDOT Synthesis MethodsApplication of oCVD PEDOT in Rechargeable BatteriesApplications of Solution-Based PEDOT in Rechargeable BatteriesConclusions and Outlook
Discovering the Site-Selective Umpolung of Ketones Triggered by Hypervalent Fluoro-Iodanes – Why Investigating Side Reactions Matters!
Authors: Gulder Tanja , Kretzschmar Martin 
Published: December 2022

AbstractIn this account, we describe our journey leading to the discovery of a generally applicable umpolung method for the α-functionalization of ketones. Central to this reaction is the cyclic hypervalent fluoro-iodane, which is mostly known for various alkene functionalizations enabling, for example, the synthesis of fluoro-benzoxazepines, indoles, and ketones. During this work, we encountered α-functionalized ketones as minor side products. This observation prompted us to further investigate this reactivity, thus revealing a directed umpolung of pyridyl ketones by the fluoro-iodane. The key to the success was the unexpected non-covalent interaction between the nucleophile, substrate, and iodane.1	Introduction2	Cyclizations Triggered by the Fluorination of Styrenes3	Umpolung Reactions Facilitated by Hypervalent Iodanes4	Discovering and Evolving a Fluoro-Iodane-Triggered Regioselective α-Functionalization of Carbonyl Compounds5	First Investigations on the Nitrogen-Directed Umpolung6	Conclusion
Medical Marijuana Legalization in Oklahoma: Effects on Neonatal Exposure to Opiates
Authors: DeShea Lise , Rolfs Shanna , McCoy Mike , Beasley William H. , Szyld Edgardo , Makkar Abhishek 
Published: December 2022

Objective The U.S. opioid epidemic has been characterized by increases in opioid misuse, overdose deaths, and neonatal opioid withdrawal syndrome. Research suggests that marijuana legalization has contributed to decreased use of opiates, although many studies had methodological weaknesses and failed to address the pregnant population. Implementation of medical cannabis laws has the potential to reduce maternal opioid use and, therefore, neonatal exposure to the drugs. This study aimed to examine the association between Oklahoma's implementation of state medical marijuana laws and the neonatal exposure to opioids.
Study Design Electronic medical records at two sites (Oklahoma City and Lawton) were searched for results of cord, urine, and meconium screens to detect amphetamines, barbiturates, benzodiazepines, cocaine, ethanol, opiates, phencyclidine, and tetrahydrocannabinol (THC). Two study periods were compared: 19 months before Oklahoma's medical marijuana law took effect and 19 months after legalization began.
Results A total of 16,804 babies were born alive at the two sites during the study period. The rate of positive THC tests per 1,000 liveborn infants significantly increased from 16.2 per 1,000 during the prelaw period to 22.2 per 1,000 during the postlaw period (p = 0.004). Neonatal opioid exposure incidence showed a nonsignificant decrease from 7.6 positive tests per 1,000 liveborn infants to 6.8 per 1,000 from prelaw to postlaw period (p = 0.542). The number of positive tests for THC and concomitant use of opioids doubled from the prelaw period (n = 4) to postlaw (n = 9), but there were too few cases for statistical significance. Infants at the more rural site had significantly higher rates for amphetamines, benzodiazepines, and THC, with a trend toward higher rates for opiates.
Conclusion Marijuana legalization was related to significant increases in positive test rates for THC, but no significant change/association was noted for neonatal exposure to opioids.
Key Points
Outcomes among Nulliparous Women Undergoing Nonmedically Indicated Induction of Labor at 39 Weeks Compared with Expectant Management Differ by Maternal Age
Authors: Hersh Alyssa R. , Urbanowicz Erin , Garg Bharti , Schmidt Eleanor M. , Packer Claire H. , Caughey Aaron B. 
Published: December 2022

Objective Prior studies have demonstrated the potential benefit of nonmedically indicated induction of labor for nulliparous women at 39 weeks of gestation, yet few have studied the impact of this management strategy in different maternal age groups on obstetric outcomes. We sought to assess whether obstetric outcomes among women undergoing nonmedically indicated induction of labor at 39 weeks of gestation as compared with expectant management vary based on maternal age.
Study Design This was a retrospective cohort study of singleton, nonanomalous, deliveries between 2007 and 2012 in California. We defined nonmedically indicated induction of labor as induction of labor without a specific medical indication, and women with planned cesarean sections were excluded. We compared induction of labor with expectant management beyond the gestational age of induction and examined this comparison in different maternal age groups. Numerous maternal and neonatal outcomes were examined. Chi-squared and multivariable logistic regression analyses were used for statistical comparisons and a p-value of less than 0.05 was used to indicate statistical significance.
Results A total of 630,485 women–infant dyads met our inclusion criteria and were included in this study. At 39 weeks' gestation, 6% of women underwent nonmedically indicated induction of labor and 94% underwent expectant management. Women 20 to 34 and ≥35 years old had lower odds of cesarean delivery if they underwent induction of labor. Women of all ages undergoing nonmedically indicated induction of labor had higher odds of operative vaginal delivery. Neonatal outcomes were better with nonmedically indicated induction of labor, including lower odds of neonatal intensive care unit admission and neonatal respiratory distress.
Conclusion Our study demonstrated that obstetric outcomes vary among women undergoing nonmedically indicated induction of labor compared with expectant management when stratified by maternal age. These findings illustrate the importance of understanding age-related differences in outcomes associated with nonmedically indicated induction of labor.
Key Points
Efficient Computation of the Interaction Energies of Very Large Non-covalently Bound Complexes
Authors: Gorges Johannes , Bädorf Benedikt , Hansen Andreas , Grimme Stefan 
Published: December 2022

AbstractWe present a new benchmark set consisting of 16 large non-covalently bound systems (LNCI16) ranging from 380 up to 1988 atoms and featuring diverse interaction motives. Gas-phase interaction energies are calculated with various composite DFT, semi-empirical quantum mechanical (SQM), and force field (FF) methods and are evaluated using accurate DFT reference values. Of the employed QM methods, PBEh-3c proves to be the most robust for large systems with a relative mean absolute deviation (relMAD) of 8.5% with respect to the reference interaction energies. r2SCAN-3c yields an even smaller relMAD, at least for the subset of complexes for which the calculation could be converged, but is less robust for systems with smaller HOMO–LUMO gaps. The inclusion of Fock-exchange is therefore important for the description of very large non-covalent interaction (NCI) complexes in the gas phase. GFN2-xTB was found to be the best performer of the SQM methods with an excellent result of only 11.1% deviation. From the assessed force fields, GFN-FF and GAFF achieve the best accuracy. Considering their low computational costs, both can be recommended for routine calculations of very large NCI complexes, with GFN-FF being clearly superior in terms of general applicability. Hence, GFN-FF may be routinely applied in supramolecular synthesis planning.1	Introduction2	The LNCI16 Benchmark Set3	Computational Details4	Generation of Reference Values5	Results and Discussion6	Conclusions
Supercharge End-to-Side Sensory Transfer to A Long Nerve Graft to Enhance Motor Regeneration in A Brachial Plexus Model—An Experimental Rat Study
Authors: Daniel Bassem W. , Giesen Teun , Lu Johnny Chuieng-Yi , Chang Tommy Nai-Jen , Zavala Abraham , Chuang David Chwei-Chin 
Published: December 2022

Abstract
Background Long nerve grafts will affect muscle recovery. Aim of this study is to investigate if supercharged end-to-side (SETS) sensory nerve transfer to long nerve graft can enhance functional outcomes in brachial plexus animal model.
Methods A reversed long nerve graft (20–23-mm) was interposed between C6 and musculocutaneous nerve (MCN) in 48 SD rats. The sensory nerves adjacent to the proximal and distal coaptation sites of the nerve graft were used for SETS. There were four groups with 12 rats in each: (A) nerve graft alone, (B) proximal SETS sensory transfer, (C) distal SETS sensory transfer, and (D) combined proximal and distal SETS sensory transfers. Grooming test at 4, 8, 12 and 16 weeks, and compound muscle action potentials (CMAP), biceps tetanic muscle contraction force, muscle weight and MCN axon histomorphologic analysis at 16 weeks were assessed.
Results Grooming test was significantly better in group C and D at 8 weeks (p = 0.02 and p = 0.04) and still superior at 16 weeks. There was no significant difference in CMAP, tetanic muscle contraction force, or muscle weight. The axon counts showed all experimental arms were significantly higher than the unoperated arms. Although the axon count was lowest in group C and highest in group D (p = 0.02), the nerve morphology tended to be better in group C overall.
Conclusion Distal sensory SETS transfer to a long nerve graft showed benefits of functional muscle recovery and better target nerve morphology. Proximal sensory inputs do not benefit the outcomes at all.