bluuebunny/crossref_metadata_2025_split huggingface dataset:
Snake Envenomation in the Intensive Care Unit of a Tertiary Care Hospital, Dhaka, Bangladesh: A Prospective Cohort Study
Authors: Sarker Subroto Kumar , Salim Mohammad , Hossain Md Mozaffer , Mandal Biplab Kumar 
Published: May 2022

Background: Snake bite and the subsequent envenomation is an important health hazard which may lead to fatality in rural areas of Bangladesh.
Objective: This study was conducted to evaluate the epidemiology, clinical profile, treatment and outcome for patients with snake bite admitted in the intensive care unit of Dhaka Medical College Hospital, Bangladesh.
Methodology: This prospective cohort study was conducted in the Department of Anaesthesia, Analgesia, Palliative and Intensive Care Medicine, Dhaka Medical College, Dhaka, Bangladesh from May 2019 to April 2020 for a period one year. The patients of snake bite were treated in the Intensive care unit, Dhaka Medical College Hospital, Dhaka, Bangladesh. A questionnaire, containing information on bite, physical examination and identification of snake was used.
Results: A total number of 23 patients of snake bite were treated in the Intensive care unit. Among the patients, 16 (69.56%) were bitten by cobra, 2 (8.6%) were suspected to be bitten by krait and 5(21.7%) cases had Russel viper bite. Tight tourniquet was used in 15(65.21%) cases. Among the patients 18(78.26%) patients were observed with the features of neurotoxicity with or without local envenoming. Among all patients, one patient required two doses of ASV, another patient needed 3 doses; but the other patients were found to be improved after getting a single dose of ASV. However, 15 patients needed ventilator support. The mean duration of ventilator support was 4.8 days. The mortality was 30.43% (7 patients). Out of these 7 patients, 4 patients died due to acute renal failure with DIC.
Conclusion: Neuroparalytic Cobra envenomation is accounted for the highest incidence of venomous bites in the present study.
Journal of Current and Advance Medical Research, January 2022;9(1):48-55
A STUDY OF STUDENTS’ PERCEPTION TOWARDS THE CORRECTIVE FEEDBACKS USED BY THE TEACHER IN CORRECTING THE STUDENTS’ WRITING PROBLEMS
Authors: Warni Asis 
Published: May 2022

This research aimed to find out the students’ perception towards the corrective feedbacks used by the teacher in correctinng the students’ writing problems. The reseach employed descriptive method. The sample of this research was selected by using random sampling technique. The instruments of data collection was a students’ checklist. The data of the students’ perception towards the corrective feedback stated that 59,09% students said that direct corrective feedback help them to understand what to do to correct their errors. Next, the result shown that 54,55% of the students also mentioned that they can notice and understand their errors about punctuation, spelling, and capitalization through indirect corrective feedback easily. Furthermore, half of them or 50% of the sample students told that indirect corrective feedback encouraged them to write in a better topic and details. In conclusion, the corrective feedbacks improve student’s ability in writing especially descriptive text and the students have positive perceptions about the corrective feedbacks. Keywords: Perception, Corrective Feedback, Writing
Adversity Quotient and Learning Interests To Mathematics Learning Achievement
Authors: Rustan Edhy , Ihsan Muhammad , Nurlindasari Nurlindasari 
Published: May 2022

Abstrak. Terdapat beberapa faktor yang memengaruhi prestasi belajar matematika. Faktor tersebut diantaranya adversity quotient dan minat belajar. Tujuan penelitian ini untuk mengetahui hubungan Adversity Quotient (AQ) dan minat belajar terhadap prestasi belajar matematika, serta faktor yang paling mempengaruhi prestasi belajar matematika. Penelitian ini adalah penelitian kuantitatif ex-post facto, dengan menggunakan angket dan dokumentasi. Populasi dalam penelitian ini adalah seluruh siswa kelas XI di salah satu SMK Negeri di Palopo, dengan sampel sebesar 76 siswa. Teknik analisis yang digunakan adalah dengan metode analisis Structural Equation Model (SEM) berbantuan aplikasi AMOS 24. Hasil penelitian menunjukkan bahwa ada hubungan Adversity Quotient dan minat belajar terhadap prestasi belajar matematika siswa kelas XI SMK Negeri Palopo secara simultan. Variabel Adversity Quotient dan minat belajar berhubungan positif dan signifikan terhadap prestasi belajar ( . Variabel confidence memiliki hubungan yang paling besar yaitu 0,508 sedangkan hubungan yang paling kecil ditunjukkan oleh hubungan antara Interest dan Liveliness terhadap prestasi dengan koefisien 0,227. Dengan demikian, dalam meningkatkan prestasi belajar matematika siswa, tidak cukup hanya dengan minat melainkan membutuhkan adversity question terutama aspek kepercayaan diri.Kata Kunci: Adversity Quotient, Minat Belajar, Prestasi Belajar
Korelasi antara Keyakinan Belajar dan Pemahaman Konseptual Kalkulus pada Calon Guru Matematika
Authors: Tamba Kimura Patar , Appulembang Oce Datu , Listiani Tanti 
Published: May 2022

Abstrak. Keyakinan adalah faktor penting dalam mempengaruhi praktek pembelajaran matematika di dalam kelas. Keyakinan belajar kalkulus diasumsikan memiliki korelasi dengan pemahaman konseptual kalkulus. Penelitian ini bertujuan untuk menguji hubungan antara keyakinan belajar kalkulus dan pemahaman konseptual kalkulus. Penelitian menggunakan metode survei dengan desain cross-sectional terhadap 65 orang calon guru matematika yaitu mahasiswa pendidikan matematika pada semester tiga dan lima. Data keyakinan belajar kalkulus dikumpulkan dengan kuisioner. Data pemahaman konseptual kalkulus dikumpulkan dengan menggunakan instrumen Calculus Concept Inventory. Analisis data dilakukan secara kuantitatif dengan memakai statistik deskriptif dan inferensial. Statistik deskriptif yang digunakan adalah rata-rata, maksimum, minimum dan standar deviasi. Statistik inferensial yang digunakan adalah korelasi product-moment. Hasil penelitian menunjukkan tidak terdapat korelasi signifikan antara keyakinan belajar kalkulus dan pemahaman konseptual kalkulus calon guru matematika, calon guru matematika cenderung memegang keyakinan campuran mengenai belajar kalkulus, dan kemampuan pemahaman konseptual calon guru matematika berada pada kategori rendah. Implikasinya adalah pentingnya menerapkan berbagai pendekatan dalam pembelajaran kalkulus karena kecenderungan calon guru matematika memegang keyakinan campuran serta mempertimbangkan faktor lain diluar keyakinan mengenai belajar kalkulus. Kata Kunci: Keyakinan belajar kalkulus, Pemahaman konseptual kalkulus, Calculus concept inventory
Abstraksi Matematika Sebagai Epistemological Obstacles dalam Pemodelan Pembelajaran SPLDV di Sekolah Menengah
Authors: Sumbandari Akhmad , Misdalina Misdalina , Fuadiah Nyiayu Fahriza 
Published: May 2022

Abstrak. Penelitian ini merupakan prospective analysis yang merupakan rangkaian dari didactical design research. Penelitian ini dilatarbelakangi oleh miskonsepsi dan alur pembelajaran yang melewati lintasan belajar yang mengakibatkan terjadinya learning obstacles. Dengan demikian, tujuan dari penelitian ini adalah untuk menganalisis hambatan belajar dalam pemodelan matematika dari permasalahan yang berkaitan dengan SPLDV. Metode yang digunakan pada penelitian ini adalah metode kualitatif. Analisis yang dilakukan adalah analisis epistemological obstacles yang berkaitan dengan intervensi didaktis pada kurikulum, RPP, dan wawancara terhadap guru mata pelajaran. Analisis epistemological obstacles juga dilakukan dengan tes diagnostik terhadap siswa kelas 9 SMPN 1 Mendo Barat dan siswa kelas 11 IPA SMAN 1 Mendo Barat. Dari hasil analisis menunjukkan epistemological obstacles dalam pemodelan matematika dari permasalahan yang berkaitan dengan SPLDV. Berdasarkan hasil penelitian, epistemological obstacles yang dominan adalah siswa kesulitan dalam melakukan pemodelan matematika. Terdapat 90,9 % siswa SMP tidak dapat membuat model matematika dengan tepat. Hal yang sama terjadi pada siswa SMA dengan persentase kejadian 86,66 %. Epistemological obstacles yang ditemukan adalah kesulitan dalam melakukan abstraksi yang mengakibatkan siswa tidak dapat melakukan pemodelan matematika dalam menyelesaikan SPLDV. Hasil dari penelitian ini dapat menjadi dasar untuk merancang desain pembelajaran dalam pemodelan matematika agar learning obstacles pada pembelajaran SPLDV dapat diminimalisir. Kata Kunci: Epistemological Obstacles, Abstraksi Matematika, Pemodelan matematika, Didactical Design Research
Uji Kecocokan Model Parameter Logistik Soal Diagnosa Kemampuan Matematika Dasar
Authors: Hartono Wahyu , Hadi Samsul , Rosnawati Raden , Retnawati Heri 
Published: May 2022

Abstrak. Penilaian diagnostik kognitif berfungsi untuk mengukur struktur pengetahuan teknis siswa dan kemampuan pemrosesan untuk memberikan informasi tentang kekuatan dan kelemahan kognitifnya. Penelitian ini bertujuan untuk menganalisis kesesuaian model teori respon butir soal tes diagnostik kemampuan matematika dasar. Jenis penelitian ini adalah penelitian deskriptif eksploratif dengan pendekatan kuantitatif. Subyek penelitian sebanyak 200 responden yang merupakan mahasiswa mahasiswa tingkat 1,2,3 dan 4 dari 7 program sarjana Universitas Swadaya Gunung Jati. Instrumen yang digunakan berupa tes materi eksponensial berbentuk multiple-choice sebanyak 12 butir. Data yang diperoleh berupa respon siswa pada instrumen tes yang diberikan. Teknik analisis datanya adalah analisis karakteristik butir berdasarkan teori respons butir (IRT). Analisis uji prasyarat model IRT dengan analisis faktor. Uji asumsi independensi lokal berdasarkan penghitungan korelasi antar item. Sedangkan uji invariansi parameter menggunakan scatter plot. Berdasarkan hasil penelitian ini diperoleh nilai korelasi poin biserial butir nomor empat adalah negatif, sehingga butir tersebut tidak digunakan dalam analisis parameter dan kecocokan model. Model teori respons butir yang cocok dengan instrumen tersebut adalah model 3-PL. Tingkat kesukaran item berada dalam rentang sampai 0,901. Daya pembeda berada dalam rentang sampai serta tebakan semu ada di antara 0 sampai . Jika ditinjau dari tingkat kesulitan butir terbukti bahwa keseluruhan butir memiliki tingkat kesulitan yang baik, sehingga dapat disimpulkan bahwa seluruh butir memiliki karakateristik butir yang baik. Penelitian ini memberikan gambaran pengujian empiris dalam menentukan kualitas butir instrumen berdasarkan analisis yang tepat sehingga layak untuk digunakan dalam mengukur hasil belajar.Kata Kunci: Tes Diagnosa, Teori Respons Butir, Model Logistik Parameter.
Interpersonal Communication Model and Learning Readiness Among Santri in Achieving The Success of Study at Higher-Educational Institutions
Authors: Sholeh Ahmad , Yaqien Nurul 
Published: May 2022

This study aims to determine to what extent the education system of Islamic boarding schools (known as Pondok Pesantren) is related to the model of interpersonal communication and pesantren students (known as santri) readiness to learn can contribute to their success while taking the level in higher education. The authors used the quantitative method as the research approach. This research was conducted at the Pondok Pesantren "Anwarul Huda" Karang Basuki, Malang. To solve the problems in this study, two statistical analysis techniques were used, namely descriptive statistics and multiple regression analysis. The results of this study indicated that first, most of the santri studying at higher educational institutions (universities) had poor interpersonal communication, quite good learning readiness, and good learning outcomes. Second, the santri’s interpersonal communication model and learning readiness significantly contribute to university learning outcomes achievement by 7.6% and other factors that influence the rest. This analysis indicates that santri’s interpersonal communication and learning readiness have not been optimally carried out in Islamic boarding schools. Therefore, every educator should always provide directions to generate and develop santri’s interpersonal communication model and learning readiness to maximize their learning outcomes in higher education.
Fractional photothermolysis as up-to-date technology for skin regeneration
Authors: Kuznetsova E. K. , Kudrevich Y. V. , Ziganshin O. R. , Dolgushin I. I. 
Published: May 2022

The use of lasers in medical cosmetology today is widespread. The effects of laser techniques are pronounced and persistent. It is known that skin microcirculation increases after the procedures, renewal of keratinocytes and fbroblasts is stimulated, but there is little information about the molecular basis of the action of ablative lasers, about the mechanisms underlying the formation of new tissues (various types of collagens, laminin, vessels of the microvasculature).Purpose of the study. Formation of a detailed understanding of the mechanisms underlying the regenerative processes of the skin after ablative laser exposure.Results. After ablative laser exposure, the amount of interleukin-1α signifcantly increases, which leads to stimulation of the formation of type I and III collagens, laminin. There is an increase in vascular, fbroblast growth factor, which also helps to stimulate the proliferation of fbroblasts, increase its blood supply.Conclusions. Based on the data obtained, it can be concluded that fractional photothermolysis improves the elastic properties of the skin, enhances skin trophism and activates the metabolism of the skin. The prolongation of the effects of a single procedure is due to the activation and stimulation of the skin’s own regenerative resources, which contributes to an increase in its own fbroblasts, collagens, vessels of the microvasculature, cells of the epidermis and dermis.
Sub-Lethal Concentrations of Graphene Oxide Trigger Acute-Phase Response and Impairment of Phase-I Xenobiotic Metabolism in Upcyte® Hepatocytes
Authors: Romaldini A. , Spanò R. , Catalano F. , Villa F. , Poggi A. , Sabella S. 
Published: May 2022

The impact of graphene oxide on hepatic functional cells represents a crucial evaluation step for its potential application in nanomedicine. Primary human hepatocytes are the gold standard for studying drug toxicity and metabolism; however, current technical limitations may slow down the large-scale diffusion of this cellular tool for in vitro investigations. To assess the potential hepatotoxicity of graphene oxide, we propose an alternative cell model, the second-generation upcyte® hepatocytes, which show metabolic and functional profiles akin to primary human hepatocytes. Cells were acutely exposed to sub-lethal concentrations of graphene oxide (≤80 μg/ml) for 24 h and stress-related cell responses (such as apoptosis, oxidative stress, and inflammatory response) were evaluated, along with a broad investigation of graphene oxide impact on specialized hepatic functions. Results show a mild activation of early apoptosis but not oxidative stress or inflammatory response in our cell model. Notably, while graphene oxide clearly impacted phase-I drug-metabolism enzymes (e.g., CYP3A4, CYP2C9) through the inhibition of gene expression and metabolic activity, conversely, no effect was observed for phase-II enzyme GST and phase-III efflux transporter ABCG2. The GO-induced impairment of CYP3A4 occurs concomitantly with the activation of an early acute-phase response, characterized by altered levels of gene expression and protein production of relevant acute-phase proteins (i.e., CRP, Albumin, TFR, TTR). These data suggest that graphene oxide induces an acute phase response, which is in line with recent in vivo findings. In conclusion, upcyte® hepatocytes appear a reliable in vitro model for assessing nanomaterial-induced hepatotoxicity, specifically showing that sub-lethal doses of graphene oxide have a negative impact on the specialized hepatic functions of these cells. The impairment of the cytochrome P450 system, along with the activation of an acute-phase response, may suggest potential detrimental consequences for human health, as altered detoxification from xenobiotics and drugs.
Reproductive and Developmental Toxicity Assessment of Human Umbilical Cord Mesenchymal Stem Cells in Rats
Authors: Li Xiaobo , Huang Qijing , Zhang Xiangxiang , Xie Changfeng , Liu Muyun , Yuan Yueming , Feng Jianjia , Xing Haoyu , Ru Li , Yuan Zheng , Xu Zhiyong , Yang YaoXiang , Long Yan , Xing Chengfeng , Song Jianping , Hu Xiang , Xu Qin 
Published: May 2022

Objective: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown very attractive potential in clinical applications for the treatment of various diseases. However, the data about the reproductive and developmental toxicity of hUC-MSCs remains insufficient. Thus, we assessed the potential effects of intravenous injection of hUC-MSCs on reproduction and development in Sprague-Dawley rats.Methods: In the fertility and early embryonic development study, hUC-MSCs were administered at dose levels of 0, 6.0 × 106, 8.5 × 106, and 1.2 × 107/kg to male and female rats during the pre-mating, mating and gestation period. In the embryo-fetal development study, the pregnant female rats received 0, 6.0 × 106, 1.2 × 107, and 2.4 × 107/kg of hUC-MSCs from gestation days (GD) 6–15. Assessments made included mortality, clinical observations, body weight, food consumption, fertility parameters of male and female, litter, and fetus parameters, etc.Results: No hUC-MSCs-related toxicity was observed on the fertility of male and female rats, and no teratogenic effect on fetuses. hUC-MSCs at 1.2 × 107/kg caused a mildly decrease in body weight gain of male rats, transient listlessness, tachypnea, and hematuria symptoms in pregnant female rats. Death was observed in part of the pregnant females at a dose of 2.4 × 107/kg, which could be due to pulmonary embolism.Conclusion: Based on the results of the studies, the no-observed-adverse-effect levels (NOAELs) are 8.5 × 106/kg for fertility and early embryonic development, 1.2 × 107/kg for maternal toxicity and 2.4 × 107/kg for embryo-fetal development in rats intravenous injected with hUC-MSCs, which are equivalent to 8.5-fold, 12-fold, and 24-fold respectively of its clinical dosage in humans. These findings may provide a rational basis for human health risk assessment of hUC-MSCs.
Dynamic Changes in the Aorta During the Cardiac Cycle Analyzed by ECG-Gated Computed Tomography
Authors: Zhu Wenying , Wang Yingliang , Chen Yang , Liu Jiacheng , Zhou Chen , Shi Qin , Huang Songjiang , Yang Chongtu , Li Tongqiang , Xiong Bin 
Published: May 2022

BackgroundTo characterize the difference in aortic dimensions during the cardiac cycle with electrocardiogram (ECG)-gated computed tomography angiography (CTA) and to determine whether other parameters in comparison to diameter could potentially provide a more accurate size reference for stent selection at the aortic arch and the proximal thoracic descending aorta.MethodsThe CTA imaging of 90 patients during the cardiac cycle was reviewed. Three anatomic locations were selected for analysis (level A: 1 cm proximal to the innominate artery; level B: 1 cm distal to the left common carotid artery; and level C: 1 cm distal to the left subclavian artery). We measured the maximum diameter, the minimum diameter, the lumen area, the lumen perimeter, and the diameter derived from the lumen area, and the changes of each parameter at each level during the cardiac cycle were compared.ResultsThe mean age was 60.9 ± 12.4 years (range, 16–78 years). There was a significant difference in the aortic dimensions during the cardiac cycle (p &lt; 0.001). The diameter derived from the lumen area at all three levels was changed least over time when compared to the area, perimeter, and the maximum aortic diameter (all p &lt; 0.01).ConclusionThe aortic dimensional differences during the cardiac cycle are significant. The aortic diameter derived from the lumen area over other parameters may provide a better evaluation for selecting the size of the stent at the aortic arch and the proximal thoracic descending aorta. A prospective study comparing these different measurement parameters regarding the outcomes is still needed to evaluate the clinical implications.
Is the Risk of Diabetes Lower in Patients With Atrial Fibrillation Treated With Direct Oral Anticoagulant Compared to Warfarin?
Authors: Liu Xuyang , Feng Shenghui , Chen Zhuohui , Zhou Yue , Yin Kang , Xue Zhengbiao , Zhu Wengen 
Published: May 2022

BackgroundThe use of anticoagulants is an established strategy to prevent stroke, embolism, and cardiovascular mortality in patients with atrial fibrillation (AF), but its role in the prevention of incident diabetes is unclear. We aimed to investigate this question by using participant data from cohort studies.MethodsWe conducted a meta-analysis of participants to investigate the impact of direct oral anticoagulants (DOACs) on the risk of new-onset diabetes in AF patients. The collection of related data was performed in the PubMed and EMBASE databases until December 2021, including studies associated with evaluating the correlation between DOACs and incident diabetes. The hazard ratios (HRs) and 95% confidence intervals (CIs) were adjusted by the random-effects model with an inverse variance method.ResultsTwo cohort studies with a total of 24,434 patients were included in this study (warfarin: n = 6,906; DOACs: n = 17,528). Compared with warfarin, the use of DOACs could reduce the incident diabetic risk in AF patients (HR = 0.75, 95%CI: 0.68–0.82). Investigations about the effects of three major classes of DOACs showed that the individual use of dabigatran (HR = 0.76, 95%CI: 0.64–0.90), rivaroxaban (HR = 0.74, 95%CI: 0.64–0.87), apixaban (HR = 0.74, 95%CI: 0.60–0.92) and the combined use of rivaroxaban and apixaban (HR = 0.74, 95%CI: 0.66–0.84) could reduce the risk of new-onset diabetes compared with warfarin. This risk reduction effect could be observed in both male and female groups (HR = 0.73, 95%CI: 0.64–0.84, P &lt; 0.00001; HR = 0.82, 95%CI: 0.82–0.99, P = 0.04).ConclusionsTreatment with DOACs compared with warfarin reduced the risk of new-onset diabetes in both male and female patients with AF.