bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiating phonological delay from phonological disorder: Executive function performance in preschoolers
Authors: Waring Rebecca , Rickard Liow Susan , Dodd Barbara , Eadie Patricia 
Published: January 2022

AbstractBackgroundThe conversational speech of most children can be understood by people outside the family by the time they reach 4 years. However, for some children, speech sound disorders (SSDs) persist into their early school years, and beyond, despite adequate hearing, oromotor function, and language learning opportunities. One explanation for children's SSDs are domain‐general cognitive‐linguistic deficits that impair the child's ability to correctly derive rules governing how speech sounds legally combine to form words in a specific language.AimsTo explore whether there are differences in performance on executive function tasks between children who make speech errors characteristic of phonological delay and those who make speech errors characteristic of phonological disorder.Methods & ProceduresTwenty‐six children aged from 3;6 to 5;2 (13 with phonological delay and 13 with phonological disorder), matched pairwise for age and sex (nine males), were assessed on tasks measuring cognitive flexibility (rule abstraction and cognitive shift) and phonological working memory.Outcome & ResultsFor the cognitive flexibility tasks, the performance of children with phonological delay was significantly better than that for children with phonological disorder, but there were no group differences for the phonological working memory task.Conclusions & ImplicationsChildren with phonological disorders might benefit from intervention programmes that incorporate training in cognitive flexibility.What is already known on the subjectChildren with phonological delay and phonological disorder comprise the two largest SSD subgroups that present to speech‐language therapy clinics. Evidence suggests domain‐general cognitive processes (e.g., phonological working memory, ability to revise faulty underlying representations, rule abstraction, and cognitive shift) influence phonological development. Differences between the two subgroups in the types of speech errors, linguistic abilities, developmental trajectories, and responses to intervention have been reported, yet little is known about the underlying cognitive‐linguistic deficits.What this paper adds to existing knowledgeThe results of this study suggest that children with phonological delay and phonological disorder have distinct patterns of performance on executive function tasks: Children with phonological disorder showed deficits in domain general rule‐abstraction and cognitive shift when compared to children with phonological delay.What are the potential or actual clinical implications of this work?The findings draw attention to: (1) the importance of differential diagnosis of phonological delay and phonological disorder; (2) the role of domain‐general cognitive processes in explaining why children make particular types of errors; and (3) the need to develop innovative and tailored intervention techniques that target specific underlying deficits.
Linking Entrepreneurial Orientation to Environmental Collaboration: A Stakeholder Theory and Evidence from Multinational Companies in an Emerging Market
Authors: Bouguerra Abderaouf , Hughes Mathew , Cakir M. Selim , Tatoglu Ekrem 
Published: January 2022

AbstractRevisiting stakeholder theory as a potential theory of the firm giving rise to expectations about organizing, we analyze when and under what circumstances entrepreneurially oriented firms increase their environmental collaboration with suppliers. Specifically, we investigate the association between entrepreneurial orientation and environmental collaboration with suppliers by accounting for the degree of employees’ work engagement and market environment complexity as stakeholder‐oriented moderators of this relationship. We test our hypotheses using multi‐level analyses on 249 managers nested in 66 multinational companies (MNCs) in Turkey. We find that entrepreneurial orientation positively impacts environmental collaboration with suppliers. A high level of work engagement (as an organizing principle favouring a stakeholder focus) and a low level of market environment complexity (as an organizing principle favouring the customer as an instrumental stakeholder) moderate this linkage. We enrich the debate on entrepreneurial orientation, strategy, and environmental sustainability by providing logic rooted in stakeholder theory of the conditions under which MNCs’ entrepreneurial orientation in emerging markets prioritizes and privileges environmental collaboration with suppliers.
Data‐driven mergers and personalization
Authors: Chen Zhijun , Choe Chongwoo , Cong Jiajia , Matsushima Noriaki 
Published: January 2022

AbstractThis article studies tech mergers that involve a large volume of consumer data. The merger links the markets for data collection and data application through a consumption synergy. The merger‐specific efficiency gains exist in the market for data application due to the consumption synergy and data‐enabled personalization. Prices fall in the market for data collection but generally rise in the market for data application as the efficiency gains are extracted away through personalized pricing. When the consumption synergy is large enough, the merger can result in monopolization of both markets. We discuss policy implications including various merger remedies.
Local consolidative therapy for synchronous oligometastatic non‐small cell lung cancer treated with first‐line pembrolizumab: A retrospective observational study
Authors: Chen Ya , Wang Yanan , Yang Zhengyu , Hu Minjuan , Lu Jun , Zhang Yanwei , Qian Fangfei , Zhang Bo , Wang Shuyuan , Wang Kai , Zhang Wei , Han Baohui 
Published: January 2022

AbstractBackgroundLocal consolidative therapy (LCT) has emerged as a treatment option in patients with oligometastatic non‐small cell lung cancer (NSCLC) undergoing chemotherapy or targeted therapy. However, the current literature lacks evidence as to whether LCT improves survival in NSCLC patients receiving immunotherapy. Our study aimed to assess whether LCT combined with pembrolizumab ± chemotherapy could improve the survival of patients with synchronous oligometastatic NSCLC.MethodsPatients with NSCLC, without EGFR or ALK genetic aberrations, who were treated with first‐line pembrolizumab ± chemotherapy, were included in the study. Survival analysis of the LCT and non‐LCT groups was compared.ResultsA total of 231 patients were included in the study. The median follow‐up time was 15.24 months. Median progression‐free survival (PFS) and overall survival (OS) of the entire cohort were 12.00 and 23.43 months, respectively. Of the 231 patients included, 76 patients received LCT combined with pembrolizumab ± chemotherapy (LCT group) while 155 patients received pembrolizumab ± chemotherapy alone (non‐LCT group). Of note, the PFS of the LCT and non‐LCT groups was 13.97 and 10.08 months (p = 0.016), respectively. The OS were 30.67 and 21.97 months (p = 0.011), respectively. The PFS and OS were significantly improved with LCT for patients with brain or lung metastases but not bone metastases. No significant increase in treatment‐related toxicity was observed in the LCT group.ConclusionsThe present study shows that LCT to metastatic sites is an option for consideration in patients with synchronous oligometastatic NSCLC during first‐line pembrolizumab treatment, with significantly improved PFS and OS compared with systemic treatment alone.
ESCROpath, a Bayesian mixing model to quantify diets and trophic flows in aquatic food webs
Authors: Lobry Jérémy , Mounier Florence , Ballutaud Marine , Chevillot Xavier , Gascuel Didier , Budzinski Hélène , Labadie Pierre , Drouineau Hilaire 
Published: January 2022

AbstractFood‐web modelling is a key tool to provide a global and comprehensive knowledge on community structure, biodiversity and ecosystem processes and functioning. In particular, it allows computing integrative and holistic indices describing food web characteristics, topology and functioning. However, one of the main sources of uncertainty in most food‐web models is the estimation of diet matrices.In the present work, we propose an innovative approach that combines (a) a Bayesian mixing model using both isotopes and contaminants as chemical tracers with (b) classical mass‐balance equations. This dual approach allows the simultaneous estimation of diet composition, isotopic enrichment, contaminant biomagnification, and contaminants and biomass flows in the whole food web. This original model named ESCROpath also provides food‐web indices derived from ecological network analysis (ENA). As a case study, the approach was implemented in the Gironde estuarine food web (SW France) for which isotopes, contaminants and trophic data exist. Two sets of priors were constructed accounting for more or less uncertainty in trophic parameter estimates. Outputs were compared with previous published Ecopath results.A constrained calibration led to very similar outputs as Ecopath (which shows that the method is able to find the initial set of parameters if it is forced to do so), whereas a free calibration led to slight differences in trophic parameters and ENA indice estimations (which shows that the Ecopath solution was not fully optimal). Quite different diet matrices and estimations of flows distribution within the food web can thus be obtained.ESCROpath is an original flexible food‐web modelling tool that, for the first time, makes it possible to go from a model mainly built on an ‘estimate’ of the parameters based on expert knowledge (which constitutes the main criticism formulated against Ecopath) to a statistical Bayesian framework for the estimation of the trophic parameters. It thus provides a very integrated framework for food‐web modelling by estimating simultaneously trophic parameters, diet compositions and trophic enrichment/magnification factors. By doing this, it notably provides reliable and robust uncertainty estimations for output parameters.
Witnessing “imperfect victims”
Authors: HUSSAIN SALMAN 
Published: January 2022

ABSTRACTAfter the 9/11 attacks, Pakistan's military government unleashed a program of extrajudicial detentions to surveil and track down “Islamic terrorists.” These men are known as the “missing” or “disappeared” persons in the movement mobilized by their families to protest the abductions. Ethnographic research with the families of “missing persons” in Pakistan, however, involves working with people whom I call “imperfect victims”—that is, persons who do not easily fit the subject position of those occupying the “suffering slot.” Such imperfect victims often rely on nonnormative ethics of grief and sacrifice to help them make sense of violence stemming from larger political‐economic structures of power. An ethnography of imperfect victims responds to calls for going beyond the “suffering subject” in anthropology. It does so by questioning the humanitarian assumption in anthropology that suffering is a common, apolitical ground for all humanity and that a politics of solidarity can be built on the suffering of others. [witnessing, suffering subject, ethnography, human rights, disappearances, missing persons, Pakistan, South Asia]
Narrative review of the systemic inflammatory reaction to cardiac surgery and cardiopulmonary bypass
Authors: Squiccimarro Enrico , Stasi Alessandra , Lorusso Roberto , Paparella Domenico 
Published: January 2022

AbstractBackgroundData from large cardiac surgery registries have been depicting a downward trend of mortality and morbidities in the last 20 years. However, despite decades of medical evolution, cardiac surgery and cardiopulmonary bypass still provoke a systemic inflammatory response, which occasionally leads to worsened outcome. This article seeks to outline the mechanism of the phenomenon.MethodsA thorough review of the literature has been performed. Criteria for considering studies for this non‐systematic review were as follows: observational and interventional studies investigating the systemic inflammatory response to cardiac surgery, experimental studies describing relevant molecular mechanisms, and essential review studies pertinent to the topic.ResultsThe intrinsic variability of the inflammatory response to cardiac surgery, together with its heterogenous perception among clinicians, as well as the arduousness to early discriminate high‐responder patients from those who will not develop a clinically relevant reaction, concurred to hitherto unconclusive randomized controlled trials. Furthermore, peremptory knowledge about the pathophysiology of maladaptive inflammation following heart surgery is still lacking.ConclusionsSystemic inflammation following cardiac surgery is a frequent entity that occasionally becomes clinically relevant. Specific genomic differences, age, and other preoperative factors influence the magnitude of the response, which elements display extreme redundancy and pleiotropism that the target of a single pathway cannot represent a silver bullet.
Previous intravitreal injection as a risk factor of posterior capsule rupture in cataract surgery: a systematic review and meta‐analysis
Authors: Bjerager Jakob , van Dijk Elon H. C. , Holm Lars Morten , Singh Amardeep , Subhi Yousif 
Published: January 2022

AbstractPurposeIntravitreal injections and cataract surgery are two common procedures in the elderly. Posterior capsular rupture (PCR) is a rare but important complication of cataract surgery. We systematically reviewed the literature on previous intravitreal injections as a risk factor of PCR and performed meta‐analyses to provide pooled summary risk estimates.MethodsWe searched 13 literature databases on 1 June 2021 for studies evaluating the risk of PCR in eyes undergoing cataract surgery with data on previous intravitreal injections. Data extraction was made independently by two authors and discussed afterwards until reaching consensus. Random effects meta‐analyses on the pooled odds ratio (OR) of PCR in eyes with previous intravitreal injections were made using MetaXL 5.3.ResultsSix studies on 1 051 097 eyes undergoing cataract surgery were eligible for the qualitative and quantitative review. Previous history of intravitreal injections was present in 7034 eyes (majority was anti‐VEGF). Our meta‐analyses revealed that any previous intravitreal injection was a risk factor for PCR with an OR of 2.30 (95% CI 1.39–3.81). For each previous intravitreal injection, the risk of PCR was OR 1.04 (95% CI 1.01–1.08) (equivalent of relative risk ~1.04). In other words, risk of PCR increases by 4% for each previous intravitreal injection.ConclusionsPrevious intravitreal injection is a risk factor for PCR and should be taken into account when planning cataract surgery. However, to be regarded as a clinically significant risk of PCR, a substantial number of previous intravitreal injection (e.g. ≥10) should have been administered, considering that the a priori risk of PCR is very low (~1%).
Vector control reduces the rate of species invasion in the world's largest freshwater ecosystem
Authors: Ricciardi Anthony , MacIsaac Hugh J. 
Published: January 2022

AbstractThe Great Lakes‐St Lawrence River basin is the world's most invaded freshwater system. Ballast water release from transoceanic shipping is deemed responsible for 65% of invasions in the basin since the modern St. Lawrence Seaway opened in 1959. Regulations requiring mid‐ocean exchange of ballast water applied in 1993 failed to stem ship‐mediated invasions because the procedure was not mandated for all ships. In 2006 and 2008, Canada and the United States, respectively, mandated that all transoceanic ships should conduct open ocean flushing to ensure that partially filled ballast tanks intended for discharge into the Great Lakes contained water of salinity ≥30 ppt before entering the Seaway. These regulations have been strictly enforced through record inspections and tests of ballast tank salinities of inbound ships. Before‐and‐after comparisons of total organismal abundance and species richness in ballast tanks revealed a substantial reduction in invasion risk from ships that conducted saltwater flushing. Since 2006, the rate of discovery of newly established non‐native species in the Great Lakes declined by 85% to its lowest level in two centuries. While multiple factors could plausibly contribute to this decline, empirical evidence supports the 2006/2008 ballast water regulation as the primary cause, highlighting the benefit of internationally coordinated vector control.
Fostering landscape immunity to protect human health: A science‐based rationale for shifting conservation policy paradigms
Authors: Reaser Jamie K. , Hunt Brooklin E. , Ruiz‐Aravena Manuel , Tabor Gary M. , Patz Jonathan A. , Becker Daniel J. , Locke Harvey , Hudson Peter J. , Plowright Raina K. 
Published: January 2022

AbstractAnthropogenic land use change is a major driver of zoonotic pathogen spillover from wildlife to humans. According to the land use‐induced spillover model, land use change alters environmental conditions that in turn alter the dynamics between zoonotic pathogens and their wildlife hosts. Thus, in response to the global spread of the SARS‐CoV‐2 virus (the agent of COVID‐19 disease), there have been renewed calls for landscape conservation as a disease preventive measure, including by the G7 Ministers responsible for Climate and the Environment. Landscape immunity, as a new construct, points to four paradigm shifts the world must favor to effectively mitigate pandemic risks. We provide a landscape immunity primer for policy makers and make the case for “world views” that placeHomo sapienswithin ecological systems, regard human health as an ecological service, prioritize investments in prevention, and apply ecological restoration to human health goals. Crisis is a conversation starter for reimagining and recommitting ourselves to what is most vital and generative. We urge world leaders to make the move to a nature‐positive world.
Influence of feeder cells on transcriptomic analysis of pluripotent stem cells
Authors: Wan Haifeng , Fu Rui , Tong Man , Wang Yukai , Wang Libin , Wang Siqi , Zhang Ying , Li Wei , Wang Xiu‐Jie , Feng Guihai 
Published: January 2022

AbstractObjectivesHuman pluripotent stem cells (hPSCs) are of great importance in both scientific research and regenerative medicine. The most classic and widely used culture method for hPSCs is co‐culture with feeder cells, usually mouse embryonic fibroblasts. However, whether these feeder cell residues can affect the transcriptomic data analysis of hPSCs, especially gene or miRNA expression quantification, is still largely unknown.Methods and ResultsIn this study, reanalysis of published mRNA‐Seq and miRNA‐Seq data sets revealed the existence of feeder cell‐derived reads in the hPSC transcriptomic samples. We identified potentially influenced human genes and miRNAs due to misalignment of sequencing fragments affected by mouse feeder cells. Furthermore, we developed an optimized miRNA analysis pipeline to avoid quantification bias from different miRNA isoforms in the same family. Finally, by comparing the levels of feeder cell residues in hPSC samples isolated by different methods, we found that fluorescence‐activated cell sorting and adhesion methods were more effective in feeder cell removal than the gradient centrifugation method.ConclusionsCollectively, our results demonstrate that feeder cell residues affect the transcriptomic data analysis of hPSCs. To minimize the impact of feeder cell contamination in hPSC samples, we provide solutions for both data analysis and sample preparation.
Saving species beyond the protected area fence: Threats must be managed across multiple land tenure types to secure Australia's endangered species
Authors: Kearney Stephen G. , Carwardine Josie , Reside April E. , Adams Vanessa M. , Nelson Rebecca , Coggan Anthea , Spindler Rebecca , Watson James E. M. 
Published: January 2022

AbstractThe main effort to secure threatened species globally is to set aside land and sea for their conservation via governance arrangements such as protected areas. But not even the biggest protected area estate will cover enough area to halt most species declines. Consequently, there is a need for assessments of how species habitats are distributed across the tenure landscape, to guide policy and conservation opportunities. Using Australia as a case study, we assess the relationship between land tenure coverage and the distributions of nationally listed threatened species. We discover that on average, nearly half (48%) of Australian threatened species' distributions occur on privately owned (freehold) lands, despite this tenure covering only 29% of the continent. In contrast, leasehold lands, which cover 38% of Australia, overlap with only 6% of species' distributions while protected area lands (which cover 20%) have an average of 35% of species' distributions. We found the majority (75%; n = 1199) of species occur across multiple land tenures, and those species that are confined to a single tenure were mostly on freehold lands (13%; n = 201) and protected areas (9%; n = 139). Our findings display the opportunity to reverse the current trend of species decline with increased coordination of threat management across land tenures.
Endemism, projected climate change, and identifying species of critical concern in the Scrub Mint clade (Lamiaceae)
Authors: Naranjo Andre A. , Melton Anthony E. , Soltis Douglas E. , Soltis Pamela S. 
Published: January 2022

AbstractRecent studies have revealed that narrow endemics, particularly those native to the North American Coastal Plain, are experiencing range contractions due to human development and anthropogenic‐driven climate warming. We model how the projected distributions of a group of scrub‐adapted plant species with similar evolutionary histories change in response to warming climates. The Scrub Mint clade (Lamiaceae) (SMC), which comprises 24 species in Dicerandra, Conradina, Stachydeoma, Piloblephis, and Clinopodium, including federally or state‐listed threatened and endangered species, occurs in the scrub and sandhill biomes of the North American Coastal Plain. Georeferenced occurrence points were used to develop species distribution models (SDMs) to assess both present and predicted future ranges of all SMC species under future climate change. Future SDMs show that suitable environments for 67% of the SMC species would cover reduced geographical areas than at present. This loss of habitat is most pronounced in species of the Florida peninsula but is also prevalent in species found farther north. We use SDMs to identify the most at‐risk species and geographic areas. Narrowly endemic species were more susceptible to habitat loss than those species with wider ranges. Using a large dataset and modeling habitat suitability at this regional scale, we demonstrate that scrub‐adapted species are highly vulnerable to habitat reduction as a result of climate change.