bluuebunny/crossref_metadata_2025_split huggingface dataset:
LBMON141 Macroorchidism In A Patient With A Functional Gonadotroph Macroadenoma
Authors: Chale-Matsau Bettina , Van Staden Louis P , Kemp Tanja , Pillay Tahir S 
Published: November 2022

Abstract

Background
Functioning gonadotroph adenomas (FGAs) are rare, since most pituitary adenomas of gonadotroph origin are clinically silent or non-functioning. FGAs produce hormones that are adequate to result in clinical syndromes. Clinical case We describe a 38-year-old male who presented with pressure effects from a sellar mass manifesting as persistent and progressive headache. He also complained of swelling of the feet, excessive sweating and coarsening of facial features as well as increased libido. The patient also reported symptoms consistent with obstructive sleep apnoea. His shoe size remained the same and had no features of acromegaly. His visual fields appeared intact on informal assessment. He appeared well virilised and had bilateral macroorchidism, with both testes markedly larger than the largest measurement on the orchidometer (25ml). He was found to have elevated follicle stimulating hormone (FSH) 26.7 to 38.4 IU/L [1.3 -19.3] and testosterone levels from 28.1 to 44.3 nmol/L [6.1 - 27.1] with luteinising hormone (LH) levels being either inappropriately non-suppressed or high, 5.7 - 12.3 IU/L [1.2 - 8.6]. He also had erythrocytosis [Hb 19.5 to 21.7 g/dL (14.3 -18.3) and macroorchidism, owing to high gonadotropin levels. The rest of his pituitary axis appeared intact, including TFT, cortisol levels, and IGF-1, were all within normal limits. Although histology of the pituitary adenoma could not be obtained as the patient declined surgery, clinical and biochemical findings were supportive of FGA diagnosis.

Conclusions
FGAs are rare, can have none or subtle clinical features, and often present late with mass effects. Functional gonadotroph adenoma should be suspected in a patient with a sellar mass, with high or non-suppressed gonadotropins in the presence of elevated gonadal steroids. Clinical features such as macroorchidism and polycythaemia may be easily missed or misinterpreted. Surgical removal should be the therapy of choice, and if successful can lead to reversal of the biochemical and clinical abnormalities.
Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.
LBMON65 Generation Of Serum Insulin Like Growth Factor -1 (IGF-1) Normative Data According To Age, Tanner Staging & Bone Age In Healthy Indian Children And Adolescents With Two Different Assays: The Germinative Study
Authors: Teja Ravi , Dutta Pinaki , Korbonits Márta , Marwaha Raman K , Malhotra Bhanu , Rastogi Ashu , Mukherjee Soham , Pal Rimesh , Bhansali Anil , Bhadada Sanjay , Walia Rama , Das Liza , Aggarwal Arun , Monaghan Phillip , James Peter 
Published: November 2022

Abstract

Context
To diagnose and monitor GH-related disorders, serum IGF-I is a cornerstone, but Indian ethnicity based data, following consensus criteria for establishment of normative data are not available.

Objectives
To generate normative IGF-I data for chronological age (CA), Tanner stage and bone age (BA) [Greulich & Pyle (GP)] for both genders. Setting and Participants: We conducted a cross-sectional epidemiological study for Indian children (age 5-18 years) that included 2226 apparently normal subjects (1145 males; 1081 females). We used robust clinical exclusion criteria initially and later statistically we removed outliers separately for Age,Tanner Stage & Bone age using software SPSS 26. 0. Outcome Measures:: Serum IGF-I (ng/ml) using the Roche ECLIA & Immunodiagnostic Systems & Immunoassay System (IDS iSYS) were measured and normative data for 2.5th, 5th,10th, 25th, 50th (median), 75th, 90th, 95th and 97.5th centiles were generated.

Results
Age- and gender-specific serum IGF-I normative data generated from a uniquely large cohort reflected various patterns. With Roche assay, females (n=910) had IGF-I median peak at 13 years (356.85) [BA (n=804) at 14 years (401.5 ng/mL)] and & Tanner (n = 936) stage IV (368) while males (n=959) had median peak at 14 years (329.5) [BA (n=906) at 15 years (351 ng/mL)] & Tanner (n = 986) stage III (311. 0). With IDS iSYS assay, females had IGF-I median peak at Age (n=913) 13 years (397.5), Tanner (n=941) stage IV (418.5) and GP BA (n=843) 14 years (448.5) and males had median peak at Age (n=974) 14 years (376), Tanner (n=1003) stage III (367) and GP BA (n=909) 15-16 years (383). Females had earlier rise & peak and higher IGF-I values with both assays. In Tanner-specific data maximum difference noticed between stage II and III in both genders with both assays. On comparison of both assays, IGF-1 median peak was achieved at similar ages and Tanner stage but all the values are higher with IDS iSYS assay. When reviewed published literature on Caucasians, females had IGF-I median peak at 15 years (300.1) and Tanner stage III (382.8) and males had median peak at 15 years (318.3) and Tanner stage IV (439). The Indian & Caucasian IGF-1 normative data clearly demonstrates that every ethnicity has a unique pattern of growth.

Conclusions
The normative data on serum IGF-I are ethnicity-specific and it will improve the diagnostic utility of IGF-I in evaluation and management of growth disorders in Indian Children. Using both age- and Tanner stage-specific normative data simultaneously can improve diagnostic work-up.
Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.
LBODP075 Vanishing Pituitary Macroadenoma
Authors: Naik Vaishali Shashikant 
Published: November 2022

Abstract

Introduction
-Clinical presentation of Pituitary macroadenoma and Lymphocytic hypophysitis may mimic each other. It is necessary to be cautious when one treats these patients and follow up with clinical response and hormonal and radiological evaluation is important to differentiate between the two pathologies.

Case presentation
Sixty years lady with no comorbidities presented with giddiness and vomiting for three days. She was found to have high blood pressure and was started on betablocker. This was followed by hypotension and bradycardia for which patient required admission. On admission she had persistent hypotension and bradycardia required inotropes for 48 hours. Her routine investigations were unremarkable but S. sodium was 117 (135-145 mEq/L). Endocrine reference was for persistent hyponatremia. History did not reveal any significant medical or surgical problems. She did not have headaches, visual complaints or polyuria. Clinical examination was unremarkable. Her hormonal profile was done and started on intravenous steroids. There was dramatic response to the steroid treatment. Her investigations - Urine spot Na 40 (more than 20meq/L), Urine specific gravity 1. 015 (1. 005-1. 030), Urine osmolarity 210.6mosm/kg of water (500-850) Serum osmolarity of 257.7 moms/kg(275- 295), Random bloodsugar 106 mg/dl(less than 140), Cortisol 1.91 mcg/dl (10-20), ACTH 5.59 pg/ml(10-60), Ft3 1.67pg/ml(2.3-4.1) Ft4 0.7 ng/dl(0.7-1.9) TSH 0. 05mIU/L(0.5-5. 0), Prolactin 12.5 ng/ml(less than 25), LH 1.58 IU/L(19.3-100) FSH 11.85 IU/L(25-130), uric acid 3.2 mg/dl (3.5-7.2), Glycosylated Hb 5.7% (less than 5.7),serum sodium 117 mEq/L(135-145), serum K+ 4.5 meq/L (3.6-5.2), serum creatinine 0.8 mg/dl (0.6-1.3), ACE levels 21.32 mcg/L(less than 40), antiTPO antibodies 1.82 IU/mL (less than 9), IGF1 23.6 ng/ml (55-165) . MRI pituitary showed a pituitary macroadenoma. Patient improved dramatically with intravenous steroids and thyroxine 50 mcg per day. She was discharged on oral steroids prednisolone 5 mg twice a day and thyroxine 50 mcg daily. Patient followed up after 6 weeks and was clinically stable and her Ft3 was 2.46 pg/ml and FT4 was 1. 06 ng/dl with 8 am Cortisol (without steroids) 16.3 mcg/dl and ACTH 54.4 pg/ml. Her MRI pituitary after 3 months showed a normal pituitary and clinically she was stable off steroids . She is coninued on thyroxine 50 mcg and is under regular follow up.

Conclusion
- A female patient who presented in adrenal crisis with central hypothyroidism with radiological evidence of a pituitary macroadenoma which vanished on treatment of steroids. Retrospectively it was probably Lymphocytic hypophysitis which recovered over 3 months. Her hormonal profile improved. It is important to have a clinical index of suspicion while treating a Pituitary macroadenoma which may masquerade a Lymphocytic hypophysitis as the natural course of disease and treatment is different in both.
Presentation: No date and time listed
Isabel de Velasco, menina deLas Meninas, y los indios del antiguo señorío de Zinacantán en 1642–1659
Authors: Obara-Saeki Tadashi 
Published: November 2022

AbstractEste artículo muestra una relación que existió entre Isabel de Velasco, menina de Las Meninas, y los indios de Zinacantán, San Felipe, Ixtapa, Osumacinta y Simojovel de la provincia de Chiapas en Centroamérica. Cuando Isabel tenía tres años, sus padres obtuvieron la encomienda de estos cinco pueblos, y en otoño de 1659, su padre cubrió tres gastos relativos a la muerte y los funerales de Isabel con el dinero procedente de la renta de los tributos de aquellos indios. El caso de Isabel de Velasco y los indios de estos cinco pueblos nos permite entender de manera muy concreta una de las relaciones que se dieron entre la alta nobleza de Madrid y los indios de los reinos americanos a mediados del siglo xvii.
A Refuge from Science: The Practice and Politics of Rights in Brazil's Vaccine Revolt
Authors: Cantisano Pedro Jimenez 
Published: November 2022

Abstract
This article considers the rights-based opposition that helped fuel Rio de Janeiro's 1904 Vaccine Revolt. I argue that the revolt was embedded in sociolegal conflicts about the policing of homes. In the early twentieth century, empowered by new laws, public health agents invaded homes to disinfect them with sulfur to kill the mosquitoes that transmitted yellow fever, and to vaccinate residents against smallpox. An elite coalition invoked the constitutional right to the home's inviolability against state interference in this private space. For working-class people, this rights language resonated with long-lasting struggles for inclusion and equality. Since the nineteenth century, they had associated their homes with freedom, honor, and autonomy. Moreover, judicial records reveal that a less diverse group composed of immigrants, property owners, and labor leaders requested court orders to stop forced residential disinfections. This article shows how resistance in courts and on the streets mutually fueled each other.
Poverty Alleviation from the Margins: Mexico's IMSS-COPLAMAR as a Challenge to Global Health and Economic Models, 1979–1989
Authors: Soto Laveaga Gabriela 
Published: November 2022

AbstractA 1970s and 1980s poverty alleviation program, IMSS-COPLAMAR, challenged universal definitions of poverty as well as health models for rural areas while proffering a distinctly Mexican alternative. Yet this solution, broadly painting rural dwellers as marginados (marginalized), focused on need-based definitions of social exclusion and thus incongruously erased ethnic diversity while celebrating Indigenous forms of healing. Indeed, linking notions of poverty to health programs redefined poverty in the late twentieth century as an economically preventable ailment. More problematically, the term marginados tended to flatten the complex identities of the rural poor. Despite these faults, the program was groundbreaking and inventive in its conception. At its core, this article shows how radically innovative and socially inclusive domestic programs that emerged in the late twentieth century from the so-called developing world found it difficult to compete against—and survive—prescriptive solutions pushed by international organizations, especially at the dawn of neoliberal reforms.
A Forgotten Family Portrait
Authors: Cecil Elizabeth A. 
Published: November 2022

Abstract
Ancient Daśapura was the site of an internally complex Śaiva religious community. The Aulikara rulers used Śaivism as a political idiom to celebrate military might and royal power. Their ministers, the Naigamas, promoted an irenic vision that praised Śiva as a source of protection and prosperity. Attention to those expressions of Śaivism enable us to contextualize one of Daśapura's most famous, yet enigmatic, works of art: an ithyphallic male figure depicted with a double phallus (ca. sixth c. ce). To date, the sculpture has remained impossible to place within the greater artistic landscape of the region. This study proposes a resolution by showing that the icon was conceived as part of a triad of sculptures that included Śiva's wife, Pārvatī, and their son, Skanda. The images of Śiva and Skanda are displayed at the Bhopal Museum, and while their similarities have been noted in previous studies, they have not been viewed as part of a set. The reason for this is their separation from an unpublished Pārvatī that currently is displayed in the Mandasor Archaeological Museum and identified as a yakṣī. When viewed as part of a triad, the double-phallus figure is transformed from an iconographic puzzle into an innovative visual strategy to reconcile what might seem opposing facets of a divine persona—that is, the ascetic and the family man. By presenting these icons as a “family portrait,” this study recontextualizes important works of art from early India and initiates broader considerations of the political and religious ideologies that inspired their production.
Art-Historical Fiction or Fictional Art History?
Authors: Park J. P. 
Published: November 2022

AbstractIn 1634 Zhang Taijie (b. 1588) published a woodblock edition of Baohuilu (A Record of Treasured Paintings), an extensive catalog of a massive painting collection he claimed to have built. This work would seem to be a useful resource for historians of Chinese art since it provides accounts of paintings by artists whose works are no longer extant. But there is one major problem: the book is a forgery. What is more, Zhang also forged paintings to match the documentation he created, so he could also profit from trading in them. Interestingly, the book also echoes unfounded claims registered in art-historical writings of the time, wherein leading critics and connoisseurs, including Dong Qichang (1555–1636), propounded completely contrived arguments by which they tried to establish legitimate lineages in Chinese art. Such propositions represent, borrowing from Eric Hobsbawm's insight, a kind of “invented tradition,” a fictional history of practice and artifact that runs as some thought it ought to have, rather than as it did. By looking into all the three major components of forgeries in early modern China that are referenced throughout Zhang Taijie's catalog—(1) fabricated texts, (2) forged paintings, and (3) fake histories/theories—this paper aims to explain how Baohuilu facilitated Zhang's candid desire for fame and profit in the booming art market of the time, while unveiling certain cultural, social, and genealogical anxieties and tensions negotiated in the form of art-historical theories.
“Structure and Subject Matter” at Dunhuang
Authors: Linrothe Rob 
Published: November 2022

Abstract
Michelle Wang's Maṇḍalas in the Making is a groundbreaking treatment of mainly ninth- and tenth-century wall murals at Dunhuang making use of recent scholarship on early Esoteric Buddhist texts, teachers, and themes in Chinese and Tibetan sources. The review article assesses and extends the understanding and definitions of forms of mandala in India and China, recognizing the distinction between textual accounts of internal, visualized mandalas (bhāvyamaṇḍala), and the external, physical objects (lekhyamaṇḍala). Questions concerning the role(s) of the viewer and the purpose(s) of the Dunhuang shrines for the patrons and designers are also raised. For the patrons and designers, the shrines surely provided opportunities for acts of merit-making and expressions of gratitude for good fortune. For viewers and later visitors, were the shrines coded expressions of discursive Buddhist “meaning” and “repentance rituals,” as Wang mainly argues, or (perhaps also) locales for gestalt experience of the presence of consecrated deities? The attribution of the visual style to a Nepalese-derived Tibetan mode is also examined.
Urban Popular Economies
Authors:   The Urban Popular Economy Collective, Benjamin Solomon , Castronovo Alioscia , Cavallero Luci , Cielo Cristina , Gago Véronica , Guma Prince , Gupte Rupali , Habermehl Victoria , Salman Lana , Shetty Prasad , Simone AbdouMaliq , Smith Constance , Tonucci João 
Published: November 2022

AbstractWhat is a life worth living and how is it concretely actualized by an urban majority making often unanticipated, unformatted uses of the urban to engender livelihoods in a dynamic and open-ended process? This is the key question undertaken in this collectively written piece. This means thinking about work, paid and unpaid, in ways that highlight the everyday practices of urban inhabitants as they put together territories in which to operate, which sustain their imaginations of well-being as part of a process of being with others—in households, neighborhoods, communities, and institutions. What is it that different kinds of workers have in common; what links them; where does the household begin and end; what is the difference between productive and reproductive work?
Media portrayal of vaccine: a content analysis of Vietnam online news about a pentavalent vaccine in the Expanded Program of Immunization.
Authors: Ha Nguyen Thanh , Chi Nguyen Thi Yen , Van Nuil Jennifer , Thwaites Louise , Chambers Mary 
Published: November 2022

Background: Vaccine hesitancy has become a prominent public health concern, particularly within the coronavirus disease 2019 (COVID-19) pandemic context. Worries about vaccine side effects are often cited as a reason for hesitancy, while media reporting about this topic plays an important role in influencing the public’s perspectives about vaccines and vaccination. In Vietnam, during 2012-2013, there were several adverse events following immunization (AEFIs) of Quinvaxem– a pentavalent vaccine in the Expanded Immunization Program, which made big headlines in the media. Such incidences have contributed to changes in vaccination policies and influenced parents’ concerns to date. This study explores the portrayal of Quinvaxem in Vietnam digital news during four periods marked by important events. Methods: We performed quantitative and qualitative analysis with a coding framework to identify main content focus, sentiments towards Quinvaxem, and emotional tones in these articles. Results: In total, we included 360 articles into analysis. The amount of news coverage about Quinvaxem increased after AEFIs happened, from 7 articles before AEFIs to 98 and 159 articles in the following periods when AEFIs and investigation into vaccine safety occurred. Most articles are neutral in titles (n=255/360) and content (n=215/360) towards Quinvaxem and do not convey emotional expressions (n=271/360). However, articles focusing on side effects contain negative sentiments and emotional expressions more frequently than articles of other contents while AEFIs details were conflicting across articles. Vaccine sentiments are provoked in the information about vaccine quality and safety, health authority, local delivery, and quoted vaccine opinions. Emotion-conveying elements in 89/360 articles included emotional wording and imagery and expressive punctuation. Conclusions: The heterogeneity of information in online news may reinforce uncertainty about vaccine safety and decrease vaccine intention. Our results have important implications for vaccine communication, given the current plan of the Vietnamese government to roll out COVID-19 vaccination to younger children.
From Contextualizing to Context Theorizing: Assessing Context Effects in Privacy Research
Authors: Xu Heng , Zhang Nan 
Published: November 2022

Over the past two decades, behavioral research in privacy has made considerable progress transitioning from acontextual studies to using contextualization as a powerful sensitizing device for illuminating the boundary conditions of privacy theories. Significant challenges and opportunities wait, however, on elevating and converging individually contextualized studies to a context-contingent theory that explicates the mechanisms through which contexts influence consumers’ privacy concerns and their behavioral reactions. This paper identifies the important barriers occasioned by this lack of context theorizing on the generalizability of privacy research findings and argues for accelerating the transition from the contextualization of individual research studies to an integrative understanding of context effects on privacy concerns. It also takes a first step toward this goal by providing a conceptual framework and the associated methodological instantiation for assessing how context-oriented nuances influence privacy concerns. Empirical evidence demonstrates the value of the framework as a diagnostic device guiding the selection of contextual contingencies in future research, so as to advance the pace of convergence toward context-contingent theories in information privacy.This paper was accepted by Anindya Ghose, information systems.
A Low Cost and Nondestructive Micro-Pocket Meter on Chlorophyll Contents of Vegetable Leaves
Authors: Du Rongyu , Guo Wenchuan , Zhou Yihang , Cheng Jingliang , Zhu Xinhua 
Published: November 2022

Highlights

A meter on the contents of chlorophyll a and b and total chlorophyll of vegetable leaves was developed.

Three LEDs as light sources and a light sensor to sense transmitted light through leaves.

The models to predict the chlorophyll contents were established using multiple linear regression.

The pocket detector makes chlorophyll content detection easy, fast, and in situ.

Abstract. Detecting the contents of chlorophyll (chlorophyll a, chlorophyll b) is important to instruct vegetable growth. However, the traditional spectrophotometry used in measuring these contents requires expensive equipment, is destructive, time-consuming, toxic (acetone), and unable to measure in situ. To make the detection nondestructive, quick, cheap, safe, and on-site, a low-cost micro-pocket photosynthetic chlorophyll content meter was developed in this study. The meter consisted of a micro-controller of STC12C5A60S2, three light-emitting diodes at 460, 660, and 980 nm, a digital light sensor, three keys, one organic light-emitting diode display, and a power supply unit. The software was developed by using the C language. The leaves of leaf lettuce, garden sass, and spinach were used as samples. The models used to predict the contents of chlorophyll a, chlorophyll b, and total chlorophyll, as well as SPAD values, were established based on the absorbance of vegetable leaves at three wavelengths by using the multiple linear regression method. The root-mean-squares errors of the developed meter for chlorophyll a, chlorophyll b, total chlorophyll, and SPAD value were 0.068 mg/g, 0.024 mg/g, 0.085 mg/g, and 1.7, respectively. The meter was small in size and low in cost. The contents of chlorophyll a, chlorophyll b, total chlorophyll, and SPAD value, could be given in 2 s. Keywords: Absorbance, Chlorophyll a, Chlorophyll b, Chlorophyll content, Pocket meter, SPAD.