bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfil Sociodemográfica e de Risco Cardiovascular entre Policiais do Batalhão de Operações Especiais (BOPE) e Unidades Convencionais no Rio de Janeiro
Authors: De Freitas Marçolla Vanessa , Campos de Albuquerque Denilson , Cavalcanti de Oliveira Dinaldo , Brito de Aragão Alexandre Augustus , Picone Borges de Aragão Ivana , Ferreira Esmeralci 
Published: January 2025

O Rio de Janeiro registrou 38.172 mortes por doenças cardiovasculares em 2016. Os policiais militares são expostos ao adoecimento agravados pelos fatores de risco cardiovascular (FR) e pelo estresse. Há poucos dados de literatura comparando FR em diferentes categorias da Polícia Militar do Estado do Rio de Janeiro (PMERJ). Este estudo, tem por objetivo primário avaliar aspectos sociodemográficos e FR entre o Batalhão de Operações Policiais Especiais (BOPE) e outros policiais de unidades convencionais. Inclusão: homens em atividade policial. Estudo quantitativo, observacional, transversal, com 400 policiais militares: GI= 200 BOPE e GII = 200 policiais de unidades convencionais, entre agosto/2017 até dezembro/2018. Utilizados questionários: FR, autopercepção do estresse e Inventário de Sintomas de Stress (ISS) de LIPP. Resultados: Faixa etária prevalente: 35-44 anos em ambos os grupos, mas no GI eram mais idosos (p= 0,01). Hipertensão: 15,1% (GI) e 6,5% (GII), p= 0,01; diabetes 1,5% (GI) e 4,5% (GII), p=0,14; etilismo 11,6% (GI) e 6,0% (GII), p<0,05; sedentarismo 17,6% (GI) e 17,9% (GII), p=1,0; tabagistas ativos 19,1% (GI) e 54,2% (GII), p=0,01; histórico familiar 25,6%(GI) e 21,4% (GII), p=0,34; circunferência abdominal 97,0 (GI) 95,8 (GII), p=0,02; colesterol 229,6(GI) e 209,6(GII), p=0,01. O estresse foi referido como moderado em ambos os grupos (GI – 42,7% e GII – 43,8%), p=0,61 e o ISS foi semelhante. O escore de Framinghan foi baixo em ambos os grupos (1,3%, p=0,57). Conclusões: os policiais do BOPE apresentaram maior prevalência de FR, mas sem apresentar diferenças nos parâmetros de estresse, tampouco elevado escore de risco de doença coronariana.
Oxidative Stress Biomarkers in Hypertension
Authors: Fountoulakis Petros , Kourampi Islam , Theofilis Panagiotis , Marathonitis Anastasios , Papamikroulis Georgios Angelos , Katsarou Ourania , Marinos Georgios , Oikonomou Evangelos , Siasos Gerasimos , Tousoulis Dimitris 
Published: January 2025

Abstract:
Arterial hypertension is a silent and progressive disease with deleterious vascular
implications on all target organs, including the heart, the brain, the kidneys, and
the eyes. Oxidative stress, defined as the overproduction of Reactive Oxygen Species
(ROS) over antioxidants, is capable of deteriorating not only the normal endothelial but
also the cellular function with further cardiovascular implications. Xanthine oxidase activity,
NADPH oxidase overexpression, and ROS production lead to hypertension and
high arterial tone, culminating in end-organ damage. The inactivation of NO by superoxide
reduces vasodilation and promotes peroxynitrite formation, which damages cellular
components. Activation of MMPs by oxidative stress contributes to pathological neovascularization
and angiogenesis. Salucin-β-induced activation of Angiotensin-II and
NADPH results in vascular remodeling and fibrosis, while lipid peroxidation and PARP-
1 activation further exacerbate cellular apoptosis and vascular calcification. Moreover,
to reliably assess the oxidative status an emerging number of biomarkers are under investigation.
Antioxidant therapy, alongside traditional antihypertensive agents such as
beta-blockers and ACE inhibitors, offers the potential to mitigate oxidative stress and its
detrimental effects. Additionally, polyphenols, found in plant-based foods, show
promise in managing oxidative stress in hypertensive patients although this data has not
been confirmed in randomized clinical trials. Understanding the intricate relationship between
oxidative stress and hypertension underscores the importance of developing comprehensive
therapeutic strategies to reduce cardiovascular risk and improve patient outcomes.
Integrated in Silico and in Vitro Studies of Rutin's Potential against
SARS-CoV-2 through the Inhibition of the RNA-dependent RNA
Polymerase
Authors: Metwaly Ahmed M. , El-Fakharany Esmail M , Alsfouk Aisha A. , Ibrahim Ibrahim M. , Elkaeed Eslam B. , Eissa Ibrahim. H. 
Published: January 2025

Introduction:
In our quest to identify potent inhibitors against SARS-CoV-2,
an extensive investigation was conducted for the binding and inhibitory efficacy of
Rutin against nine SARS-CoV-2 proteins.

Method:
The first step of our analysis involved a comprehensive examination of structural similarity among the co-crystallized ligands associated with those proteins. A substantial structural similarity was observed between Rutin and Remdesivir, the ligand of
the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). This similarity was validated through a flexible alignment study. Molecular docking studies, involving superimposition, revealed a notable resemblance in the mode of binding between Rutin and Remdesivir inside the active site of the RdRp. A 200 ns molecular dynamics (MD) simulation
confirmed that the RdRp-Rutin complex is more stable than the RdRp-Remdesivir complex.

Result:
The MM-GBSA studies showed that Rutin had much more favorable binding energies, with a significantly lower value of -7.76 kcal/mol compared to Remdesivir's
-2.15 kcal/mol. This indicates that the RdRp-Rutin binding is more robust and stable
PLIP and ProLIF studies helped clarify the 3D binding interactions and confirmed the
stable binding seen in MD simulations. PCAT gave more insights into the dynamic behavior of the RdRp-Rutin complex. in vitro tests showed that Rutin has a strong inhibitory effect on RdRp with an IC50 of 60.09 nM, significantly outperforming Remdesivir,
which has an IC50 of 24.56 µM. Remarkably, against SARS-CoV-2, Rutin showed a superior in vitro IC50 of 0.598 µg/ml compared to Remdesivir (12.47 µg/ml).

Conclusion:
The values of the selectivity index underscored the exceptional margin of
safety of Rutin (SI: 1078) compared to Remdesivir (SI: 5.8). In conclusion, our comprehensive analysis indicates Rutin’s promising potential as a potent SARS-CoV-2 RdRp inhibitor, providing a valuable insight for developing an effective COVID-19 treatment.
Advances in the Study for Modulators of Transient Receptor Potential Vanilloid (TRPV) Channel Family
Authors: Wang Yajing , Shi Yingying , Zuo Minmin , Yu Yingcong , Huang Xianfeng 
Published: January 2025

Abstract:
Transient receptor potential vanilloid (TRPV) channels are a member of the TRP superfamily,
which consists of six proteins and is expressed in many neuronal and non-neuronal cells.
Among them, TRPV1-4 are non-selective cation channels that are highly sensitive to temperature
changes, while TRPV5-6 are channels that are highly selective to Ca2+. These cation channels have
attracted great interest academically, especially from a pharmacological perspective. TRPV channels
play a vital role in many physiological processes and can be regulated by a variety of endogenous
stimuli as well as a range of natural and synthetic compounds. The regulation of their activities
can lead to a variety of diseases and disorders, such as neurodegenerative diseases, pain, cancer,
and skin diseases. In fact, several TRPV1 and TRPV3 modulators have been developed for
clinical use. Therefore, the development of TRPV channel modulators has important clinical significance
and value. Herein, we focused on and summarized the latest research progress of endogenous
and exogenous ligands of six TRPV channels and their pharmacological effects on related
diseases.
An Improved and Practical Approach to the Synthesis of Terbinafine as an Anti-Fungal Agent
Authors: Satteyyanaidu V. , Reddy P. Naveen , Gajula Srinivas , Poojitha U. , Nalla Ganesh , Reddy B. V. Subba 
Published: January 2025

Abstract:
An improved strategy for the synthesis of terbinafine has been developed through the crosscoupling
of (E)-aminovinyl chloride with tert-butyl acetylene using 1 mol% of 5% Pd/C as a recyclable
heterogeneous catalyst under mild conditions. This is the first report on the Pd/C catalyzed
Sonogashira coupling to produce the 99.9% pure terbinafine under mild conditions.
Benzimidazole-phenoxy-1,2,3-triazole-benzyl Derivatives as the New Potent α-glucosidase Inhibitors: Design, Synthesis, In Vitro, and In Silico Biological Evaluations
Authors: Soltani Arash , Shirzad Hadi , Panji Mohammad , Motevaseli Elahe , Mousavinezhad Seyyed Amin , Kalbasi Saeed 
Published: January 2025

Background::
α-Glucosidase inhibitors play an important role in the treatment of type 2 diabetes mellitus. Inhibitors of the latter enzyme that are available on the market creat-ed gastrointestinal side effects and achieve to a high potent and low side effect potent α-glucosidase inhibitors is a valuable target for medicinal chemists. Objective: In this study, de-rivatives of benzimidazole-phenoxy-1,2,3-triazole-benzyl skeleton were introduced as new α-glucosidase inhibitors.

Methods::
Twelve derivatives 8a-l of target scaffold were synthesized via simple chemical re-actions with a yield between 65 and 88%. The in vitro α-glucosidase inhibition activities of these compounds was evaluated against yeast form of this enzyme. After the determination of most potent compound, the interaction of this compound with α-glucosidase was evaluated in vitro by kinetic study and in silico by docking study. Drug-likeness, pharmacokinetics, and toxicity profiles of the most potent compound were predicted by an online software.

Results::
Anti-α-glucosidase assay demonstrated that all synthesized derivatives 8a-l were more potent that standard inhibitor acarbose. Representatively, 2-(4-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole (compound 8a) as the most potent deriv-ative was 150-times more potent than positive control. Kinetic study of compound 8a re-vealed that this compound is an uncompetitive inhibitor against α-glucosidase. Furthermore, molecular docking study showed that compound 8a with favorable binding energy attached to important residues in the α-glucosidase active site. This compound also can be an oral drug with favorable toxicity profile.

Conclusion::
Benzimidazole-phenoxy-1,2,3-triazole-benzyl derivatives 8a-l synthesized and evaluated for anti-α-glucosidase activity. All these compounds were excellent α-glucosidase inhibitor, and compound 8a demonstrated the most significant inhibition effect when com-pared with positive control.
Women’s Satisfaction with the Provision of Prenatal Service by the Care Providers: A Cross-Section Analytical Study
Authors: Ganji Zahra , Simbar Masoumeh , Zahrani Shahnaz Tork , Borumandnia Nasrin , Kiani Zahra 
Published: January 2025

Background:
Assessment of women's satisfaction with the quality of prenatal care
(PNC) services leads to identifying the needs and planning the appropriate interventions for quality
improvement. This study aimed to assess women's satisfaction with the provision of prenatal service
by the midwife and non-midwifery PNC providers and the related factors.

Methods:
This was an analytical cross-sectional study on 200 pregnant women for prenatal care
services. The participants were recruited using a multi-stage sampling method. The tools for data
collection were a demographic and fertility questionnaire and a questionnaire for the assessment of
clients' satisfaction with the quality of prenatal care services. The questionnaires were completed by
the participants in their last weeks of pregnancy and following six PNC visits. T T-test, ANOVA
analyzed data, Pearson's correlation and Multiple linear regression tests and using SPSS-24.

Results:
The total score of satisfaction with the quality of PNC services was 68.99 ± 9.54 percent.
There was no significant correlation between the women's satisfaction with demographic and fertility
variables (p>0.05). However, the T-test showed that women’s satisfaction with the care provided
by midwives is significantly higher than that provided by non-midwifery personnel. Multiple linear
regression showed that providing PNC by the midwives substantially increases the total satisfaction
score by 42.48 compared to the non-midwifery personnel.

Conclusion:
Providing PNC by midwives increases satisfaction compared to non-midwife PNC
providers. Therefore, the provision of care during pregnancy by midwives who are specifically
trained for perinatal care services is emphasized to improve women's satisfaction and the quality of
PNC services, which is necessary to reduce mortality and maternal and neonatal complications.

result:
The total score of satisfaction with the quality of PNC services was 68.99±9.54 percent. There was no significant correlation between the women's satisfaction with demographic and fertility variables (p>0.05). However, the T-test showed that women’s satisfaction with the provided care by midwives is significantly higher than that provided care by non-midwifery personnel. Multiple linear regression showed that providing PNC by the midwives significantly increased the total satisfaction score by 42.48 compared to the non-midwifery personnel.
A Comparative Study of CT-Guided Radiofrequency Ablation and Targeted Therapy: Intervention Efficacy and Survival Rates in Lung Cancer Patients
Authors: Zhao Tianyu , Zhang Chunjing , Dai Hang , Li Jingyu , Hao Liguo , Liu Yanan 
Published: January 2025

Objective:
The study aimed to evaluate the clinical efficacy of CT-guided radiofrequency ablation in conjunction with targeted therapy in lung cancer
patients.

Methods:
We retrospectively analyzed 80 lung cancer patients. They were stratified into the Observation Group (OG; n=40, treated with CT-guided
radiofrequency ablation in conjunction with targeted therapy) and the Control Group (CG; n=40, treated solely with targeted therapy).

Results:
The Overall Response Rate (ORR) and Disease Control Rate (DCR) in the OG group (70.00%, 95.00%) were significantly higher than those in the
CG group (57.50%, 87.50%). After 6 weeks of treatment, the OG group had significantly lower levels of SCC, CEA, and CA125, higher CD4+
levels, and lower CD8+ levels, compared to the CG group. The 24-month follow-up survival rate of the OG group (47.50%) was significantly
higher than that of the CG group (27.50%).

Conclusion:
CT-guided radiofrequency ablation and targeted therapy have been proven effective in treating lung cancer.

result:
The OG group reported 4 cases of Complete Response (CR), 24 cases of Partial Response (PR), 10 cases of Stable Disease (SD), and 2 cases of Progressive Disease (PD). The Overall Response Rate (ORR) was 70.00% (28/40), and the Disease Control Rate (DCR) was 95.00% (38/40). In contrast, the CG group exhibited 3 cases of CR, 20 cases of PR, 12 cases of SD, and 5 cases of PD. The ORR was 57.50% (23/40), and the DCR was 87.50% (35/40). The ORR and DCR in the OG group were significantly higher than those in the CG group. After 6 weeks of treatment, the levels of SCC, CEA, and CA125 in the OG group were significantly lower than those in the CG group; The CD4+ levels in the OG group were significantly higher and the CD8+ levels significantly lower than those in the CG group. A 24-month follow-up showed that the survival rate of the OG group was 47.50% (19/40), which was significantly higher than that of the CG group at 27.50% (11/40).
Perforated Meckel's Diverticulum in an Adult that Resembles Acute Appendicitis: A Case Report and Review of the Literature
Authors: Bakhsh Noha , Banjar Mai 
Published: January 2025

Background:
Perforation is one of the rarest effects of Meckel's diverticulum and may clinically resemble acute appendicitis.

Case Report:
A 34-year-old woman with pain in the right iliac fossa, nausea, and vomiting for three days was brought to the emergency department. An
abdominal examination indicated rebound tenderness in the area of the right iliac fossa. Abdominal ultrasound showed a heterogeneous lesion in
the left iliac fossa measuring 5 cm × 3.5 cm × 4 cm with no internal vascularity. Abdominal Computed Tomography (CT) demonstrated a
hypodense lesion located left of the midline of the abdomen, which was inseparable from the small bowel at the antimesenteric border.
Laparoscopic exploration was performed, and an intraoperative diagnosis of perforated Meckel’s diverticulum with phlegmon formation was made.
The patient had an uneventful recovery.

Conclusion:
Radiologists should be aware of the possibility of complicated Merkel's diverticulum when encountering cases of acute abdominal pain. If there is
a lower abdominal inflammatory process and a normal appendix is identified, there should be a high degree of suspicion when examining the CT
scan.
FedPneu: Federated Learning for Pneumonia Detection across Multiclient Cross-Silo Healthcare Datasets
Authors: Sharma Shagun , Guleria Kalpna , Dogra Ayush 
Published: January 2025

Background:
Pneumonia is an acute respiratory infection that has emerged as the predominant catalyst for escalating mortality rates worldwide. In the pursuit of
the prevention and prediction of pneumonia, this work employs the development of an advanced deep-learning model by using a federated learning
framework. The deep learning models rely on the utilization of a centralized system for disease prediction on the medical imaging data and pose
risks of data breaches and exploitation; however, federated learning is a decentralized architecture which significantly reduces data privacy
concerns.

Methods:
The federated learning works in a distributed architecture by sending a global model to clients rather than sending the data to the model. The
proposed federated deep learning-based FedPneu computer-aided diagnosis model has been implemented in 2, 3, 4, and 5 clients architecture for
early pneumonia detection using X-ray images. The key parameters configuration include batch size, learning rate, optimizer, decay, momentum,
epochs, rounds, and random-split as 32, 0.0001, SGD, 0.000001, 0.9, 10, 100, and 42, respectively.

Results:
The results of the proposed federated deep learning-based FedPneu model have been provided in terms of round-wise accuracy, loss, and
computational time. The highest accuracy of 85.632% has been achieved with 2-clients federated deep learning architecture, whereas, 3, 4, and 5
clients architecture achieved 85.536%, 76.112%, and 74.123% accuracies, respectively.

Conclusion:
In the proposed privacy-protected federated deep learning-based FedPneu model, the two-client architecture has been resulted as the most optimal
framework for pneumonia detection among 3-clients, 4-clients, and 5-clients architecture. The model works in a collaborative and privacyprotected
framework with a multi-silo dataset which could be highly beneficial for healthcare departments to maintain patient’s data privacy with
improved prediction outcomes.
Displaced Femoral Neck Fractures Treated with Percutaneous Compression Plates in Elderly Individuals: An Effect Analysis Based on Imaging
Authors: Liu Huli , Zhao Kai , Yang Ying , Dai Liansheng , Gu Sanjun , Li Haifeng , Liu Yu 
Published: January 2025

Background:
The effects of percutaneous compression plate (PCP) internal fixation for femoral neck fractures (FNFs) in elderly individuals have rarely been
reported. Therefore, this study aimed to investigate the efficacy of PCCP internal fixation for displaced FNFs in elderly individuals based on
imaging.

Methods:
The clinical data of 32 elderly patients with FNFs treated with PCCP from January 2015 to December 2022 were retrospectively analyzed. The
average age of the participants was 68.7 ± 4.8 years (range, 65–80 years). Nineteen patients had Garden type III, and 13 patients had Garden type
IV. Six patients had Pauwels type I, 15 patients had type II, and 11 patients had type III. Twelve patients had Singh index level IV, 14 patients had
level V, and 6 patients had level VI. The time from injury to operation ranged from 3–14 days, with an average of 5.8 days. A radiological
assessment was conducted. The relationships between efficacy and age, Pauwels classification, the Singh index, and the Garden alignment index
were analyzed.

Results:
At postoperative week 1, fracture reduction was acceptable in 31 patients. The time to start walking was 5.7 ± 3.7 days. The follow-up time ranged
from 2.1 to 4 years, with an average of 2.7 years. There were 2 cases of delayed healing and no cases of nonunion or internal fixation failure. The
healing time ranged from 4–8 months, with an average of 4.9 months. Fifteen patients (46.9%) showed healing with shortening of the femoral
neck, and 3 patients (9.4%) had avascular necrosis (AVN). Correlation analysis revealed that healing with shortening of the femoral neck was
positively correlated with age and the Singh index and that AVN was positively correlated with the Pauwels classification (p < 0.05).

Conclusion:
The efficacy of PCCPs for internal fixation of displaced FNFs in elderly individuals without severe osteoporosis is satisfactory, especially for
patients who can ambulate early postoperatively. The main complications are healing with shortening of the femoral neck and AVN, which are
prone to occur in patients with severe osteoporosis and Pauwels type III FNFs, respectively.
Enhanced Detection of Colon Diseases via a Fused Deep Learning Model with an Auxiliary Fusion Layer and Residual Blocks on Endoscopic Images
Authors: Kumar Rakesh , Anand Vatsala , Gupta Sheifali , Almogren Ahmad , Bharany Salil , Altameem Ayman , Rehman Ateeq Ur 
Published: January 2025

Background:
Colon diseases are major global health issues that often require early detection and correct diagnosis to be effectively treated. Deep learning
approaches and recent developments in medical imaging have demonstrated promise in increasing diagnostic accuracy.

Objective:
This work suggests that a Convolutional Neural Network (CNN) model paired with other models can detect different gastrointestinal (GI)
abnormalities or diseases from endoscopic images via the fusion of residual blocks, including alpha dropouts (αDO) and auxiliary fusing layers

Methods:
To automatically diagnose colon disorders from medical images, this work explores the use of a fused deeplearning model that incorporates the
EfficientNetB0, MobileNetV2, and ResNet50V2 architectures. By integrating these features, the fused model aims to improve the classification
accuracy and robustness for various colon diseases. The proposed model incorporates an auxiliary fusion layer and a fusion residual block. By
combining diverse features through an auxiliary fusion layer, the network can create more comprehensive and richer representations, capturing
intricate patterns that might be missed by single-source processing. The fusion residual block incorporates residual connections, which help
mitigate the vanishing gradient problem. By adding the input of the block directly to its output, these connections facilitate better gradient flow
during backpropagation, allowing for deeper and more stable training. A wide range of endoscopic images are used to assess the proposed model,
offering an accurate depiction of various disease scenarios

Results:
The proposed model, with an auxiliary fusion layer and residual blocks, exhibited an enormous reduction in overfitting and performance saturation.
The proposed model achieved an impressive 98.03% training accuracy and 97.90% validation accuracy after evaluation, outperforming the
majority of typically trained DCNNs in terms of efficiency and accuracy.

Conclusion:
The proposed method developed a lightweight model that correctly identifies disorders of the gastrointestinal (GI) tract by combining advanced
techniques, including feature fusion, residual learning, and self-normalization.