bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multi-Parametric Radiomics Nomogram for Preoperative Prediction of Microvascular Invasion Status in Intrahepatic Cholangiocarcinoma
Authors: Qian Xianling , Lu Xin , Ma Xijuan , Zhang Ying , Zhou Changwu , Wang Fang , Shi Yibing , Zeng Mengsu 
Published: February 2022

BackgroundIntrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer with increasing incidence in the last decades. Microvascular invasion (MVI) is a poor prognostic factor for patients with ICC, which correlates early recurrence and poor prognosis, and it can affect the selection of personalized therapeutic regime.PurposeThis study aimed to develop and validate a radiomics-based nomogram for predicting MVI in ICC patients preoperatively.MethodsA total of 163 pathologically confirmed ICC patients (training cohort: n = 130; validation cohort: n = 33) with postoperative Ga-DTPA-enhanced MR examination were enrolled, and a time-independent test cohort (n = 24) was collected for external validation. Univariate and multivariate analyses were used to determine the independent predictors of MVI status, which were then incorporated into the MVI prediction nomogram. Least absolute shrinkage and selection operator logistic regression was performed to select optimal features and construct radiomics models. The prediction performances of models were assessed by receiver operating characteristic (ROC) curve analysis. The performance of the MVI prediction nomogram was evaluated by its calibration, discrimination, and clinical utility.ResultsLarger tumor size (p = 0.003) and intrahepatic duct dilatation (p = 0.002) are independent predictors of MVI. The final radiomics model shows desirable and stable prediction performance in the training cohort (AUC = 0.950), validation cohort (AUC = 0.883), and test cohort (AUC = 0.812). The MVI prediction nomogram incorporates tumor size, intrahepatic duct dilatation, and the final radiomics model and achieves excellent predictive efficacy in training cohort (AUC = 0.953), validation cohort (AUC = 0.861), and test cohort (AUC = 0.819), fitting well in calibration curves (p &gt; 0.05). Decision curve and clinical impact curve further confirm the clinical usefulness of the nomogram.ConclusionThe nomogram incorporating tumor size, intrahepatic duct dilatation, and the final radiomics model is a potential biomarker for preoperative prediction of the MVI status in ICC patients.
Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice
Authors: Hanaguri Junya , Yokota Harumasa , Kushiyama Akifumi , Kushiyama Sakura , Watanabe Masahisa , Yamagami Satoru , Nagaoka Taiji 
Published: February 2022

PurposeWe investigated the effect of long-term administration of supplement with trapa bispinosa roxb. extract (TBE) and lutein on the susceptibility of retinal blood flow regulation in type 2 diabetic mice.MethodsSix-week-old db/db mice were randomly divided into the untreated group (n = 6) and the treated group received the supplement with TBE and lutein (n = 6). The longitudinal changes in retinal blood flow responses to systemic hyperoxia and a flicker stimulation were evaluated every 2 weeks in diabetes db/db mice from age 8 to 14 weeks. The retinal blood flow was assessed using laser speckle flowgraphy. We also evaluated the expressions of glial fibrillary acid protein (GFAP) and vascular endothelial growth factor (VEGF) by immunofluorescence.ResultsThe resting retinal blood flow was steady and comparable between two groups throughout the study. In db/db mice with supplement, both blood flow responses were restored from 8 to 14 weeks of age compared with diabetic mice treated with the placebo. Supplement prevented the activation of GFAP and decreased the expression of VEGF detected by immunofluorescence compared with the diabetic mice treated with placebo.ConclusionWe found that the long-term administration of supplement with TBE and lutein improved the impaired regulation of retinal blood flow in response to systemic hyperoxia and flicker stimulation, suggesting that these supplements can prevent diabetic retinopathy by improving abnormal neurovascular coupling in type 2 diabetic mice.
Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects
Authors: Araujo Gustavo S. M. , Silva Thiago O. C. , Guerra Grazia M. , Izaias João E. , Rocha Helena M. N. , Faria Diego , Rocha Natalia G. , Dalmazo Aline Lopes , Araujo Amanda , Marciano Consolim-Colombo Fernanda , de Angelis Katia , Irigoyen Maria C. C. , Sales Allan R. K. 
Published: February 2022

AimsBoth postprandial lipemia (PPL) and disturbed blood flow (DBF) induce endothelial dysfunction. However, the interactive effect of these stimuli on endothelial function is currently unknown. In the present study, we tested whether PPL plus DBF causes a greater reduction in flow-mediated dilation (FMD) than PPL and if this response is associated with elevations in oxidative stress and endothelial microvesicles (EMVs).MethodsEighteen individuals (aged 28 ± 1yrs, 3 females, and BMI 24.43 ± 0.8kg/m2) randomly underwent two experimental sessions: PPL and PPL plus DBF. FMD and venous blood samples were obtained at baseline and 30, 70, and 110 min after stimulation. PPL was induced by fat overload via mozzarella pizza ingestion and DBF by forearm cuff inflation to 75 mm Hg per 30 min. Lipidic profile, oxidative stress (thiobarbituric acid reactive substances, TBARS; ferric reducing/antioxidant power, FRAP; hydrogen peroxide, H2O2) and EMVs were measured in blood samples.ResultsHypertriglyceridemia was observed in both sessions. Retrograde shear rate and oscillatory index responses were significantly higher in the PPL plus DBF compared with PPL. PPL plus DBF evoked a greater reduction in FMD than did PPL and EMVs, NADPH oxidase, and H2O2 similarly increased in both sessions, but TBARS and FRAP did not change.ConclusionThese data indicate that the association of PPL plus DBF additively impairs endothelium-dependent function in 110 min after stimulus in healthy individuals, despite a similar increase in oxidative stress and EMVs. Further studies are needed to understand the mechanisms associated with the induced-endothelial dysfunction by association of PPL and DBF.
Empathy, Emotion Recognition, and Paranoia in the General Population
Authors: Beals Kendall , Sperry Sarah H. , Sheffield Julia M. 
Published: February 2022

BackgroundParanoia is associated with a multitude of social cognitive deficits, observed in both clinical and subclinical populations. Empathy is significantly and broadly impaired in schizophrenia, yet its relationship with subclinical paranoia is poorly understood. Furthermore, deficits in emotion recognition – a very early component of empathic processing – are present in both clinical and subclinical paranoia. Deficits in emotion recognition may therefore underlie relationships between paranoia and empathic processing. The current investigation aims to add to the literature on social cognition and paranoia by: (1) characterizing the relationship between paranoia and empathy, and (2) testing whether there is an indirect effect of emotion recognition on the relationship between empathy and paranoia.MethodsParanoia, empathy, and emotion recognition were assessed in a non-clinical sample of adults (n= 226) from the Nathan Kline Institute-Rockland (NKI-Rockland) dataset. Paranoia was measured using the Peters Delusions Inventory-21 (PDI-21). Empathy was measured using the Interpersonal Reactivity Index (IRI), a self-report instrument designed to assess empathy using four subscales: Personal Distress, Empathic Concern, Perspective Taking, and Fantasy. Emotion recognition was assessed using the Penn Emotion Recognition Test (ER-40). Structural equation modeling (SEM) was used to estimate relationships between paranoia, the four measures of empathy and emotion recognition.ResultsParanoia was associated with the Fantasy subscale of the IRI, such that higher Fantasy was associated with more severe paranoia (p&lt; 0.001). No other empathy subscales were associated with paranoia. Fantasy was also associated with the emotion recognition of fear, such that higher Fantasy was correlated with better recognition of fear (p= 0.008). Paranoia and emotion recognition were not significantly associated. The Empathic Concern subscale was negatively associated with emotion recognition, with higher empathic concern related to worse overall emotion recognition (p= 0.002). All indirect paths through emotion recognition were non-significant.DiscussionThese results suggest that imaginative perspective-taking contributes to paranoia in the general population. These data do not, however, point to robust global relationships between empathy and paranoia or to emotion recognition as an underlying mechanism. Deficits in empathy and emotion recognition observed in schizophrenia may be associated with the broader pathology of schizophrenia, and therefore not detectable with subclinical populations.
Factors Associated With Severe Fever With Thrombocytopenia Syndrome in Endemic Areas of China
Authors: Jiang Xiaolin , Wang Yiguan , Zhang Xiaomei , Pang Bo , Yao Mingxiao , Tian Xueying , Sang Shaowei 
Published: February 2022

ObjectiveTo explore the influence of climatic, environmental and socioeconomic factors on SFTS occurrence in Shandong Province, China.MethodsWe used generalized additive model to estimate the association between SFTS cases and climatic factors, environmental factors and socioeconomic factors, including annual average temperature, precipitation, land cover, normalized difference vegetation index, altitude, population density, meat production, milk production, and gross domestic product (GDP).ResultsThere were a total of 4,830 cases reported in 100 (70.9%) counties and districts in Shandong Province from 2010 to 2020. The results showed that the annual average temperature, precipitation, forest and grassland coverage rate, altitude and meat production (square root transform) had a reversed “V” relationship with SFTS occurrence, with the inflection points around 12.5–13.0°C in temperature, around 650 mm in precipitation, around 0.3 in forest and grassland coverage rate, around 300 m in altitude, and around 200–300 tons in meat production (square root transform), respectively. SFTS occurrence had a “V” relationship with milk production (square root transform) and GDP (square root transform), with the inflection points around 100–200 tons in milk production (square root transform), and around 150,000–200,000 yuan in GDP (square root transform), respectively.ConclusionsClimatic, environmental, and socioeconomic factors contributed to the heterogeneous distribution of SFTS in Shandong Province, and the influence of these factors on SFTS occurrence was nonlinear.
Influence of Epoch Length and Recording Site on the Relationship Between Tri-Axial Accelerometry-Derived Physical Activity Levels and Structural, Functional, and Hemodynamic Properties of Central and Peripheral Arteries
Authors: Gómez-García Mariana , Torrado Juan , Bia Daniel , Zócalo Yanina 
Published: February 2022

BackgroundIt remains to be established to what extent physical activity (PA) levels among individuals are independently associated with deviations from the “optimal” state of the arterial system. Accelerometers have been proposed as means to obtain reliable, objective, and more comprehensive data of PA. Decisions at the time of data collection/processing could influence the association between accelerometry-derived indices and arterial properties.Objectives(i) To identify to what extent the strength of association between arterial properties and accelerometer-derived indices depend on the recording site and/or the epoch length; (ii) to determine whether some arterial characteristics (hemodynamic vs. structural vs. functional) or regions (elastic vs. transitional vs. muscular arteries; central vs. peripheral) have higher levels of association with accelerometry-derived indices.MethodsPhysical activity (PA), cardiovascular risk factors (CRFs), and cardiovascular properties were evaluated in 60 volunteers (general population; age: 23–62 years; women: 43%). PA was measured daily for 7 days (free-living situation; triaxial-accelerometers ActiGraph-GT3X+; hip and wrist; “Worn-to-wrist” option) and raw data was converted at epoch lengths of 1, 5, 10, 30, and 60-s. PA-related energy expenditure, daily time in moderate-to-vigorous PA, steps/minute, and counts-per-minute for vector magnitude were calculated. The cardiovascular evaluation included hemodynamic (central and peripheral pressure), structural (diameters and intima-media thickness), and functional (local and regional stiffness) parameters of carotids, femoral, and brachial arteries, and carotid-femoral and carotid-radial pathways. Arterial z-scores were obtained using age-related equations derived from healthy participants not exposed to CRFs (n = 1,688; age: 2–84 years; female: 51.2%) to evaluate at which degree each parameter deviates from the “optimal” value.MethodsIn general, hip recordings outperformed those obtained on the wrist regarding the strength of association with arterial parameters. Accelerometer-derived indices and their association with arterial properties vary depending on the recording site and epoch length. PA indices are stronger associated with functional (local) than structural variables and with central than peripheral arteries.ConclusionsRegardless of the PA index, there were independent associations with central artery characteristics, which reinforces that these territories would be the most related to PA levels. Differences in data acquisition and processing could lead to differences in conclusions when addressing the association between accelerometer-derived indices and the cardiovascular system.
Interfacial Phenomena and Reaction Kinetics between High Al Molten Steel and CaO-SiO2-Type Flux
Authors: Zhao Bingbing , Zhang Jie , Yan Baijun 
Published: February 2022

To understand the reaction mechanism between high Mn-high Al steel and slag, the reaction experiment of Fe-Mn-Al melts with CaO-SiO2-type flux was carried out in MgO crucible at 1873 K. The evolution of the morphology of interface was inspected firstly, and then the global reaction kinetics was modeled in consideration of the effect of dynamic interfacial phenomena. The results show that in the reaction of Fe-5 mass % Al alloy with high SiO2 or low SiO2 protective slag, the strong chemical affinity between the metal and flux leads to strong spontaneous emulsification and attenuated with the progression of the reaction. Combined with the change of interfacial area caused by emulsification, it is found that the global reaction kinetics can be described satisfactorily by the mass transfer model of Al in liquid steel, and the determined mass transfer coefficient was about k[Al]=4.46×10−5 m/s. However, the emulsification phenomenon in the reaction of Fe-13%Mn-5%Al alloy with low SiO2 slag did not disappear with the reaction, which can be attributed to the decreasing of the interfacial tension with Mn addition and the accumulation of C on the interface. This reaction process can be modeled by assuming the mass transfer of SiO2 in the slag as the rate-controlling step with the estimated transfer coefficient of k(SiO2)=5.12×10−6 m/s.
Therapeutic and Diagnostic Tactics for Adhesive Small Bowel Obstruction: Literature Review
Authors: Клюйко Д.А. , Корик В.Е. 
Published: February 2022

Несмотря на прилагаемые усилия исследователей всего мира, количество пациентов со спаечным синдромом возрастает, остаются существенные трудности в лечении и профилактике данного заболевания. Распознавание спаечного синдрома у пациентов не является сложным диагностическим мероприятием, однако вопросы тактики ведения таких пациентов, перехода от консервативного лечения к оперативному остаются дискутабельными. Острая спаечная кишечная непроходимость является тяжелым заболеванием, в подавляющем большинстве случаев имеет странгуляционный компонент и требует агрессивной хирургической тактики. Консервативное лечение должно приводить к видимым положительным изменениям состояния пациента. При отсутствии значимой положительной динамики она должна расцениваться как отрицательная с немедленным переходом к оперативным методам лечения.
Despite the numerous efforts of researchers around the world, the number of patients with adhesive syndrome will increase; and significant difficulties remain in the treatment and prevention of this disease. Recognition of adhesive syndrome in patients is not a difficult diagnostic measure. However, the issues of tactics of managing such patients, transition from conservative treatment to surgical treatment remain controversial. Acute adhesive intestinal obstruction is a serious disease. In the overwhelming majority of cases, it has a strangulation component and requires more aggressive surgical tactics. The use of conservative therapy should lead to visible positive changes in the patient’s condition. In the absence of significant positive dynamics, it should be regarded as negative with immediate transition to operational methods of treatment.
Clinical Results of Treating Patients with Chronic Dystrophy of Ocular Surface Diseases on the Background of Corneal Syndrome
Authors: Семак Г.Р. , Майсак Ю.А. , Рындова Д.В. 
Published: February 2022

Цель исследования. Установить эффективность, переносимость, безопасность комплексного лечения пациентов с роговичным синдромом с использованием инъекционной формы 1% низкомолекулярного натрия гиалуроната и комбинированных капель с содержанием нейропротектора и антиоксиданта кроцина, гиалуроновой кислоты (ГК) и липосом (Lumixa, Омисан, Италия).Материалы и методы. Все пациенты, включенные в исследование, длительно использовали слезозаменители без должного эффекта. Препарат Lumixa назначался в виде инстилляций 3–5 раз в день на протяжении 3 месяцев, при необходимости курс продлевался до 6 месяцев. При тяжелом течении дополнительно вводилась инъекционная форма 1%-ного низкомолекулярного натрия гиалуроната.Результаты и обсуждение. Применение капель с ГК, кроцином и липосомами положительно влияло на пробу Ширмера, время разрыва слезной пленки, тест Lipcof, увеличение чувствительности роговицы, уменьшение индекса OSDI. Клинически уменьшились чувство рези, светобоязнь, слезотечение.Заключение. Показана эффективность, хорошая переносимость и безопасность комбинированных капель Lumixa в лечении пациентов с дистрофическими заболеваниями роговицы, сопровождающимися роговичным синдромом. При тяжелой болезни сухого глаза после курса с введением инъекционной формы 1%-ного низкомолекулярного натрия гиалуроната пациенты продолжали длительно применять капли с нейропротекцией.
Purpose. To establish the efficacy, tolerability, safety of complex treatment of patients with corneal syndrome using an injectable form of 1% low molecular weight sodium hyaluronate and combineddrops containing the neuroprotector and antioxidant crocin, hyaluronic acid (HA) and liposomes (Lumixa, Omisan, Italy).Materials and methods. All patients included in the study used artificial ter drops for a long time without effect. Lumixa was prescribed in the form of instillations 3-5 times a day for 3 months, if necessary, the course was extended up to 6 months. In severe cases, an injectable form of 1% low molecular weight sodium hyaluronate was additionally administered.Results and discussion. The application of drops with HA, crocin and liposomes had a positive effect on Schirmer’s test, tear film rupture time, Lipcof test. An increase in corneal sensitivity, and a decrease in the OSDI index were registered. Foreign body sensation, photophobia, lacrimation also decreased.Conclusion. The efficacy, good tolerability and safety of combined Lumixa drops in the treatment of patients with cornea degenerative diseases accompanied by corneal syndrome have been shown. In severe dry eye disease after a course with the introduction of an injectable form of 1% low molecular weight sodium hyaluronate, patients continued to use drops with neuroprotection for a long time.
Features of the Emotional-Cognitive Sphere of Patients with Somatoform Disorders on the Example of Chronic Pain Dysfunction
Authors: Коцюбинская Ю.В. , Сафонова Н.Ю. , Михайлов В.А. 
Published: February 2022

В данной работе на примере пациентов с хроническими болевыми дисфункциями исследовались особенности эмоционально-когнитивной сферы лиц с соматоформными расстройствами. В процессе исследования были выявлены статистически значимые различия между группой пациентов и контрольной выборкой как в отношении когнитивных функций, так и в эмоциональной сфере. Было обнаружено значимое снижение показателей рабочей памяти, концентрации внимания, а также общего тонуса у пациентов с соматоформными расстройствами, что, в общем, характерно для аффективных расстройств депрессивного круга. Обнаружилось, что для пациентов с соматоформными расстройствами негативное влияние аффективной интерференции на процессы запоминания выражено значительно сильнее, чем у здоровых испытуемых, тогда как статистически значимых различий по продуктивности механического запоминания не обнаружилось. Это указывает на особую роль эмоциональных нарушений в возникновении когнитивных расстройств у пациентов с соматоформными заболеваниями.
In this article, we studied the characteristics of the emotional-cognitive sphere of patients with somatoform disorders, using the example of patients with chronic pain dysfunctions. The study revealed statistically significant differences between the patient group and the control group in cognitive functions and emotional sphere. A significant decrease of memory, attention, and vitality was found in patients with somatoform disorders, which is typical for affective disorders of the depressive circle. It was found that for patients with somatoform disorders, the negative effect of affective interference on the processes of memorization is much more pronounced than in healthy subjects, while there were no statistically significant differences in the productivity of mechanical memorization. This data indicate the special role of emotional disorders in the occurrence of cognitive disorders in patients with somatoform diseases.