bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment outcomes among high‐risk neuroblastoma patients receiving non‐immunotherapy regimen: Multicenter study on behalf of the Thai Pediatric Oncology Group
Authors: Suwannaying Kunanya , Monsereenusorn Chalinee , Rujkijyanont Piya , Techavichit Piti , Phuakpet Kamon , Pongphitcha Pongpak , Chainansamit Su‐on , Chotsampancharoen Thirachit , Winaichatsak Angkana , Traivaree Chanchai , Sathitsamitphong Lalita , Kanjanapongkul Somjai , Komvilaisak Patcharee , Sanpakit Kleebsabai , Photia Apichat , Seksarn Panya , Wiangnon Surapon , Hongeng Suradej ,   Thai Pediatric Oncology Neuroblastoma Working Group
Published: May 2022

AbstractBackgroundNeuroblastoma is the most common extracranial malignant solid tumor during childhood. Despite intensified treatment, patients with high‐risk neuroblastoma (HR‐NBL) still carry a dismal prognosis. The Thai Pediatric Oncology Group (ThaiPOG) proposed the use of a multimodality treatment to improve outcomes of HR‐NBL in non‐immunotherapy settings.MethodsPatients with HR‐NBL undergoing ThaiPOG protocols (ThaiPOG‐NB‐13HR or ‐18HR) between 2013 and 2019 were retrospectively reviewed. Patient demographic data, treatment modalities, outcomes, and prognostic factors were evaluated and analyzed.ResultsA total of 183 patients with HR‐NBL undergoing a topotecan containing induction regimen were enrolled in this study. During the consolidation phase (n = 169), 116 patients (68.6%) received conventional chemotherapy, while 53 patients (31.4%) underwent hematopoietic stem cell transplantation (HSCT). The 5‐year overall survival (OS) and event‐free survival (EFS) were 41.2% and 22.8%, respectively. Patients who underwent HSCT had more superior 5‐year EFS (36%) than those who received chemotherapy (17.1%) (p = .041), although they both performed similarly in 5‐year OS (48.7% vs. 39.8%, p = .17). The variation of survival outcomes was observed depending on the number of treatment modalities. HSCT combined with metaiodobenzylguanidine (MIBG) treatment and maintenance with 13‐cis‐retinoic acid (cis‐RA) demonstrated a desirable 5‐year OS and EFS of 65.6% and 58.3%, respectively. Poorly or undifferentiated tumor histology and cis‐RA administration were independent factors associated with relapse and survival outcomes, respectively (p < .05).ConclusionA combination of HSCT and cis‐RA successfully improved the outcomes of patients with HR‐NBL in immunotherapy inaccessible settings.
Tri‐functional unit groups contained polyurethane composites with excellent antibacterial property and biocompatibility
Authors: Wang Chuyao , Xue Yunyun , Tian Hua , Zhao Zihao , Shen Shuyang , Fang Lifeng , Cui Ronglu , Han Jun , Zhu Baoku 
Published: May 2022

AbstractAs biomaterials, it is essential for polyurethane (PU) to have excellent antibacterial activity and biocompatibility at the same time. Herein, quaternary ammonium groups, sulfonic groups, and alkyl groups simultaneously introduced hyperbranched poly(amidoamine) (HPA‐QSA) was synthesized, which was further used to blend with PU and prepared as films. HPA‐QSA/PU blend films showed strong antibacterial activity to kill more than 99.99% of both Gram‐positive and Gram‐negative bacteria due to the quaternary ammonium groups and long alkyl groups, as well as good biocompatibility through protein‐resistance, cytotoxicity, hemolysis assays under the combined action of cations and anions. Moreover, they exhibited stable antibacterial activity and low cytotoxicity in aquatic solutions. Overall, HPA‐QSA/PU films prepared by facile blending process exhibit great promise as low‐cost, effective antibacterial, good biocompatible materials, indicating an appealing prospect in biomedical fields.
Effects of mycorrhizae, plants, and soils on phosphorus leaching and plant uptake: Lessons learned from a mesocosm study
Authors: Rubin Jessica A. , Görres Josef H. 
Published: May 2022

Societal Impact StatementWorldwide, farmers struggle to find the most efficacious practices which balance crop fertility needs and water quality protection. Through a greenhouse experiment, we investigated how soil status (high vs. low phosphorus [P] concentration), mycorrhizae (inoculated vs. not), and plant species (dogwood vs. willow) affected P plant uptake and leaching. We found mycorrhizae did not affect uptake or leaching, more P was leached from high than low P soil, dogwood uptook yet leached more P, and above ground biomass at the end of summer contained more P than roots. This study provides insights to be considered by researchers and practitioners who implement best management practices for water quality.Summary

This research examined the effects of mycorrhizal inoculation in high and low phosphorus saturation soils on phosphorus uptake by Cornus sericea and Salix niger. The aim was to identify practices that improved water quality functions of riparian buffers to protect surface waters impacted by eutrophication.
A mesocosm experiment arranged as a random block design was conducted with mycorrhizal presence, soil phosphorus saturation status, and plant species as factors. Leachate, plant uptake, and soil phosphorus were measured to assess the effects.
Greater leachate and uptake of phosphorus were detected for C. sericea than for S. niger. Mycorrhizae had no effects on leaching nor on uptake of phosphorus in this experiment. High phosphorus saturated soils had greater leaching and uptake than the low phosphorus soils. Above ground biomass contained more phosphorus than below ground biomass in both species at time of harvest. Estimations of phosphorus removal through coppicing suggest a very slow removal rate in biodiverse multi‐functional riparian buffers.
Our results suggest that cyclical coppicing can be an improvement to Best Management Practices. Diverse riparian buffers are limited in the amount of phosphorus that they can store and mitigate, even with coppicing. The emphasis therefore should be on agricultural best management practices that reduce phosphorus export from upland fields. Further studies in phosphorus accumulating plant species with appropriate mycorrhizal symbionts are needed.
High‐resolution accurate mass approach to characterization of SCO‐267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry
Authors: Zhu Ying , Wang Ting , Zhao Na , Jiang Wenya 
Published: May 2022

RationaleSCO‐267 is a potent full agonist of G‐protein‐coupled receptor 40. As a promising therapeutic agent for type 2 diabetes mellitus, it is necessary to elucidate its metabolite profiles during the stage of drug development for safety considerations.MethodsThe in vitro metabolism was investigated by incubating SCO‐267 (5 μM) with liver microsomes and hepatocytes (rat and human). For in vivo metabolism, SCO‐267 (10 mg/kg) was orally administered to rats and plasma samples were collected. The metabolites were identified via measurements of accurate mass, elemental composition and product ions using liquid chromatography coupled to hybrid quadrupole Orbitrap high‐resolution mass spectrometry (LC‐Orbitrap‐MS).ResultsA total of 19 metabolites were structurally identified. M2 (hydroxyl‐SCO‐267), M15 (SCO‐267‐acyl‐glucuronide), M16 (desmethyl‐SCO‐267) and M17 (desneopentyl‐SCO‐267) were verified with reference standards. M2, M11, M16 and M17 were the major metabolites originating from hydroxylation, O‐demethylation and N‐dealkylation, respectively. Phenotyping study with recombinant human P450 enzymes demonstrated that hydroxylation (M2 and M11) was mainly catalyzed by CYP2C8 and 3A4; demethylation (M16) was mainly catalyzed by CYP2D6, and less catalyzed by CYP2C8 and 3A4; and N‐dealkylation (M17) was exclusively triggered by CYP3A4.ConclusionsHydroxylation, O‐demethylation, N‐dealkylation and acyl glucuronidation were the major metabolic pathways of SCO‐267. This study is the first to discover the metabolic fates of SCO‐267, which provides a basis for safety assessment of this drug candidate.
Correlations between dominant vegetation type and composition and diversity of soil bacterial communities in a subtropical forest
Authors: Cui Juyan , Yuan Ping , Zhang Qiufang , Yuan Xiaochun , Zeng Quanxin , Chen Yuehmin 
Published: May 2022

AbstractSingle and mixed vegetation types have significant effects on soil parameters and the composition and diversity of soil bacterial community. To understand the influence of different vegetation types on the structure of soil bacterial community across soil depth in a subtropical forest, we assessed the relative abundance of edaphic bacterial community and soil parameters, including pH, cation exchange capacity (CEC), and dissolved organic C in Daiyun Mountain Nature Reserve in Fujian Province, southeastern China. The study area constitutes pine coniferous forest (CF) of Pinus taiwanensis Hayata, broad‐leaved forest (BF) of Castanopsis fabri Hance, and a mixed forest comprising CF and BF (MF). Quantitative polymerase chain reaction (PCR) and Illumina sequencing of 16S ribosomal DNA were used to analyze the abundance, diversity, and composition of soil bacteria. The results showed that the pH, CEC, and diversity of tree species are all associated with the composition of bacterial community in the soil. It was found that CEC, soluble organic N, and pH largely affected the structure of soil bacterial community in A horizon, whereas CEC, moisture content, and organic P affected the structure of soil bacterial community in B horizon. We found that the dominant taxa in the CF and BF were Proteobacteria and Acidobacteria, respectively. The results of both mental and random forest analyses displayed groups according to vegetation types, indicating that the bacterial communities in the research site were significantly influenced by vegetation types in subtropical forests. The study highlights the ecological effects of forest management and elucidates the differences in the functional structure of soil bacterial communities under different vegetation types and soil depths.
Observational data from the adalimumab post‐marketing PYRAMID registry of patients with Crohn's disease who became pregnant: A post hoc analysis
Authors: Hart Ailsa , D’Haens Geert , Bereswill Mareike , Finney‐Hayward Tricia , Kalabic Jasmina , Levy Gweneth , Liang Huifang , Seow Cynthia H. , Loftus Edward V. , Panaccione Remo , Reinisch Walter , Satsangi Jack 
Published: May 2022

AbstractBackgroundPYRAMID was an international post‐marketing registry that aimed to collect data on the long‐term safety and effectiveness of adalimumab treatment per local standard of care in patients with moderately to severely active Crohn's disease (CD). Here, we present post hoc analyses of observational data from patients who became pregnant while participating in this registry and receiving adalimumab.MethodsFrom the subpopulation of patients receiving adalimumab who became pregnant while taking part in PYRAMID, data on patient characteristics, pregnancy outcomes, and complications of pregnancy were analysed retrospectively.ResultsAcross the PYRAMID registry, 293 pregnancies occurred in patients who had gestational adalimumab exposure (average disease duration at last menstrual period: 8.6 years), resulting in 300 pregnancy outcomes. A total of 197 pregnancies (67.2%) were exposed to adalimumab in all trimesters per physician's decision. Of the known reported outcomes (96.3%), 81.7% (236/289) were live births, 10.4% (30/289) were spontaneous abortions, 4.8% (14/289) elective terminations, 2.8% (8/289) ectopic pregnancies, and 0.3% (1/289) was a stillbirth. Congenital malformations (pulmonary valve stenosis and tricuspid valve incompetence) were reported in one infant. In addition to the pregnancy outcomes described above, 23 complications of pregnancy were reported in 20 patients.ConclusionsThis analysis showed that adalimumab treatment in patients with CD, who became pregnant whilst participating in the PYRAMID registry, contributed no additional adverse effects during the pregnancy course or on pregnancy outcomes.
Multidrug resistant Enterococcus faecium isolate from cholangitis/cholecystitis in a dog
Authors: Sposato Alessio , Cordisco Marco , de Ruvo Giuseppe , Ferro Silvia , Raineri Rossana Alessandra , Trotta Adriana , Buonavoglia Domenico , Corrente Marialaura 
Published: May 2022

AbstractMucocele and cholecystitis were diagnosed in a 10 year‐old Shetland‐sheepdog presenting aspecific clinical signs. Blood examinations and ultrasonography investigation were performed before to surgical approach, which allowed to collect biopsies and samples for bacteriological analyses. In addition, the patient was subjected to cholecystectomy. A multidrug resistant Enterococcus faecium was isolated from the gallbladder specimens. On the basis of antimicrobial susceptibility test, nitrofurantoin was used. The correct bacteriological diagnosis is necessary to set up effective therapy, influencing the patient's prognosis and improving the recovery time.
Enchrony
Authors: Enfield N. J. 
Published: May 2022

AbstractWhat are the properties of mind that make language the way it is, and languages the way they are? To answer those questions, it is necessary to look at the causal processes by which languagesbecomethe way they are. The relevant dynamic processes take place in different causal frames, including the familiar diachronic, phylogenetic, ontogenetic, and microgenetic frames. One frame is less frequently acknowledged and yet is arguably central to cognitive‐scientific explanations of language. This is theenchronicframe, which critically involves apublicsemiotic process (running at the time‐course of milliseconds and seconds) by which each utterance serves as an interpretant of—that is, a meaningful response to—what came before it, driving the progression of social interaction, the most experience‐near context of language usage. The notion of enchrony is needed for bringing together certain aspects of language that are typically handled by quite disparate conceptual and methodological approaches (e.g., lexical semantics, morphological typology, conversation analysis, sociolinguistic typology, diachronic linguistics). Situated within an integrated set of causal frames for language, enchrony provides conceptual tools for an account of language that foregrounds social cognition and interaction in a usage‐based model.This article is categorized under:Linguistics > Cognitive Linguistics
On wind turbine's loss of synchronisation during severe faults
Authors: Arasteh Amir , Cutululis Nicolaos A. 
Published: May 2022

AbstractGrid codes mandate that wind turbines (WTs) remain connected even during severe faults. This requirement can lead to WTs' loss of synchronisation (LoS) with the AC grid under severe symmetrical faults. In this paper, the LoS is illustrated by the power balance principle. Then, a solution with improved performance for avoiding LoS during severe faults is proposed, implemented and verified by simulations. The results show that the solution eliminates the steady‐state frequency deviation during faults, resulting in a smoother WT transient during and post‐fault.
Magic zeroes and hidden symmetries
Authors: Craig Nathaniel , Garcia Isabel Garcia , Vainshtein Arkady , Zhang Zhengkang 
Published: May 2022

Abstract
Selection rules arising from accidental or broken symmetries may be sufficiently obscure that their agency is hidden, leading to the appearance of “magic zeroes” — quantities that are suppressed without apparent recourse to a symmetry explanation. Magic zeroes and their corresponding hidden symmetries may shed new light on parametric hierarchies in the Standard Model and beyond. We identify the hidden symmetry responsible for a recently-discovered magic zero, the vanishing of the putative leading contribution to the anomalous dipole moments of the muon upon integrating out weak doublet and singlet vector-like fermions. Some of the tools involved — spurion analysis leveraging discrete symmetries of the free theory, field redefinitions, spectator fields, and non-supersymmetric non-renormalization theorems — may prove useful in the hunt for new magic zeroes and their hidden symmetries.
Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model
Authors: Van Loy Tom , De Jonghe Steven , Castermans Karolien , Dheedene Wouter , Stoop Reinout , Verschuren Lars , Versele Matthias , Chaltin Patrick , Luttun Aernout , Schols Dominique 
Published: May 2022

AbstractAtypical chemokine receptor 3 (ACKR3, formerly CXC chemokine receptor 7) is a G protein-coupled receptor that recruits β-arrestins, but is devoid of functional G protein signaling after receptor stimulation. In preclinical models of liver and lung fibrosis, ACKR3 was previously shown to be upregulated after acute injury in liver sinusoidal and pulmonary capillary endothelial cells, respectively. This upregulation was linked with a pro-regenerative and anti-fibrotic role for ACKR3. A recently described ACKR3-targeting small molecule agonist protected mice from isoproterenol-induced cardiac fibrosis. Here, we aimed to evaluate its protective role in preclinical models of liver and lung fibrosis. After confirming its in vitro pharmacological activity (i.e., ACKR3-mediated β-arrestin recruitment and receptor binding), in vivo administration of this ACKR3 agonist led to increased mouse CXCL12 plasma levels, indicating in vivo interaction of the agonist with ACKR3. Whereas twice daily in vivo administration of the ACKR3 agonist lacked inhibitory effect on bleomycin-induced lung fibrosis, it had a modest, but significant anti-fibrotic effect in the carbon tetrachloride (CCl4)-induced liver fibrosis model. In the latter model, ACKR3 stimulation affected the expression of several fibrosis-related genes and led to reduced collagen content as determined by picro-sirius red staining and hydroxyproline quantification. These data confirm that ACKR3 agonism, at least to some extent, attenuates fibrosis, although this effect is rather modest and heterogeneous across various tissue types. Stimulating ACKR3 alone without intervening in other signaling pathways involved in the multicellular crosstalk leading to fibrosis will, therefore, most likely not be sufficient to deliver a satisfactory clinical outcome.
Exponential Dynamical Localization for Random Word Models
Authors: Rangamani Nishant 
Published: May 2022

AbstractWe show that one-dimensional Schrödinger operators whose potentials arise by randomly concatenating words from an underlying set exhibit exponential dynamical localization (EDL) on any compact set which trivially intersects a finite set of critical energies. We do so by first giving a new proof of spectral localization for such operators and then showing that once one has the existence of a complete orthonormal basis of eigenfunctions (with probability one), the same estimates used to prove it naturally lead to a proof of the aforementioned EDL result. The EDL statements provide new localization results for several classes of random Schrödinger operators including random polymer models and generalized Anderson models.
Use of a p64 MW Flow Diverter with Hydrophilic Polymer Coating (HPC) and Prasugrel Single Antiplatelet Therapy for the Treatment of Unruptured Anterior Circulation Aneurysms: Safety Data and Short-term Occlusion Rates
Authors: Hellstern V. , Aguilar Pérez M. , Henkes E. , Donauer E. , Wendl C. , Bäzner H. , Ganslandt O. , Henkes H. 
Published: May 2022

Abstract
Purpose
To assess the safety and short-term occlusion rates in procedures using the p64 MW hydrophilic polymer-coated (HPC) flow diverter (FD) with prasugrel single antiplatelet therapy (SAPT) for the treatment of anterior circulation saccular aneurysms.

Methods
We retrospectively identified patients who underwent treatment of one or more intracranial anterior circulation saccular aneurysms between March 2020 and December 2021 with a p64 MW HPC FD and prasugrel SAPT with verified P2Y12 platelet receptor inhibition. Patients diagnosed with fusiform, dissecting, or recently ruptured aneurysms were excluded. Periprocedural and postprocedural complications, clinical outcomes, and angiographic follow-up results were evaluated.

Results
One hundred and two patients with 132 intracranial aneurysms met the inclusion criteria. Previous or concomitant treatments (e.g., coil occlusion) had been performed on 18 of these aneurysms. The technical success rate (i.e., implantation of the intended FD) was 100% with an average of 1.1 devices implanted per patient. Periprocedural and postprocedural complications occurred in 13.6% and 6.8% of these patients, respectively. No mortality or permanent clinical deterioration (i.e., modified Rankin scale score ≥ 3) were reported. Early follow-up digital subtraction angiography revealed aneurysmal occlusion rates of 72.6% and 83.8% at four and nine months, respectively.

Conclusions
The implantation of a p64 MW HPC FD with prasugrel SAPT is safe and results in rapid, reliable and effective aneurysmal occlusion.
Axillary lymph node imaging in mRNA, vector-based, and mix-and-match COVID-19 vaccine recipients: ultrasound features
Authors: Igual-Rouilleault Alba Cristina , Soriano Ignacio , Elizalde Arlette , Quan Paola Leonor , Fernandez-Montero Alejandro , Sobrido Carolina , Pina Luis 
Published: May 2022

Abstract
Objectives
To assess ultrasound characteristics of ipsilateral axillary lymph nodes after two doses of four different COVID-19 vaccination protocols, to determine whether these parameters differed with age, and to describe how they changed on follow-up imaging.

Methods
A total of 247 volunteer employees from our center who had received two doses of COVID-19 vaccination were recruited and followed prospectively. Axillary ultrasound of the ipsilateral vaccinated arm was performed the week after receiving the second dose to analyze lymph node features (number, long-axis, cortical thickness, morphology, and vascular imaging). Axillary lymphadenopathy resulting from four vaccination protocols—mRNA (BNT162b2, mRNA-1273), ChAdOx1-S, and mix-and-match—was compared. Analysis was conducted using the Kruskal-Wallis test and post hoc analysis with Bonferroni corrections. Nodal reactogenicity was evaluated for two age groups: young (< 45 years old) and middle-aged ( ≥ 45 years old). All parameters were compared between both groups using an unpaired-sample Student t test. A p value < 0.05 was considered statistically significant.

Results
Significantly higher values for total number of visible nodes, cortical thickness, Bedi’s classification (p < 0.001), and vascularity (p < 0.05) were observed in mRNA vaccine recipients compared to full ChAdOx1-S protocol recipients. Moreover, mix-and-match protocol recipients showed greater nodal cortical thickness and higher Bedi’s classification than full ChAdOx1-S recipients (p < 0.001). Analyses between age groups revealed greater cortical thickness, Bedi’s classification, and color Doppler signal in younger patients (p < 0.05).

Conclusions
Nodal parameters of Bedi’s classification and cortical thickness were more often increased in mRNA and mix-and-match vaccine recipients when compared to ChAdOx1-S vaccine alone, especially in younger patients.

Key Points
• Hyperplastic lymphadenopathy was observed more frequently in mRNA and mix-and-match vaccine protocols compared to full vector-based vaccination.
• Higher values for cortical thickness, Bedi’s classification, and color Doppler signal parameters were identified in younger patients.
• Observed lymph node findings normalized in greater than 80% of patients by the third month following vaccination.