bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer drugs affect temperature signaling and epigenetic factors in the cold tolerance of Caenorhabditis elegans
Authors: Okahata Misaki , Sawada Natsumi , Nakao Kenji , Ohta Akane , Kuhara Atsushi 
Published: November 2022

Abstract
Drugs are vital for maintaining the body healthy and treating diseases. As most drugs have side effects, it is important to gain a complete understanding of their action mechanisms. However, significant cost and time are involved in elucidating their mechanisms. We conducted drug screening at a low cost and in a short time using the phenomenon of cold tolerance in the nematode Caenorhabditis elegans. Among ~ 4000 drugs, we screened the anticancer drugs leptomycin B and camptothecin that affect cold tolerance. Leptomycin B and camptothecin inhibited molecular pathway(s) downstream of the thermosensory signaling via the cGMP-dependent channel TAX-4 in ASJ thermosensory neurons and the thermoreceptor DEG-1 in ASG thermosensory neurons. Leptomycin B affected cold tolerance by inhibiting the molecular pathway upstream of the insulin receptor DAF-2 that regulates cold tolerance in the intestine. Camptothecin decreased the expression levels of genes required for epigenetic processes, such as hrde-1 and deps-1 encoding Argonaute and constitutive P granule protein, respectively. Moreover, hrde-1 and deps-1 mutants exhibited abnormal cold tolerance. This study established an experimental model for drug screening using the cold tolerance of C. elegans and proposed that an anticancer drug upregulates cold tolerance via temperature signaling and epigenetic regulation.
Graphical Representation of Multidimensional Poverty: Insights for Index Construction and Policy Making
Authors: Arancibia Rodrigo García , Girela Ignacio 
Published: November 2022

Abstract
By means of probabilistic graphical models, in this paper, we present a new framework for exploring relationships among indicators commonly included in the Multidimensional Poverty Index (MPI). In particular, we propose an Ising model with covariates for modeling the MPI as an undirected graph. First, we prove why Ising models are consistent with the theoretical distribution of MPI indicators. Then, a comparison between our estimates and the association measures typically used in the literature is provided. Finally, we show how undirected graphs can complement the MPI policy relevant properties, apart from discovering further insightful patterns that can be useful for policy purposes. This novel approach is illustrated with an empirical application for the global MPI indicators of Guinea and Ecuador, taking living areas and monetary poverty as covariates, respectively.
JEL Classification: I3 , C18 , C35.
Quantitative Distribution Model of Dendrites in Li metal batteries
Authors: Li Guanwu , Qin Chichu , Wang Dong , Liu Yumin , Zhang Hengguang , Wu Yingpeng 
Published: November 2022

AbstractMulti-physics field (MPF) mechanism to Li dendrite has been broadly used in developed routes of protective Li metal anode. It is proved that dendrite can be optimized by adjusting homogeneity of distributions for charge/thermal/structure through chemical reaction field, concentration field, potential field, heat field etc. However, the accurate quantitative for these distributions is still an unsolved problem. Herein, by the natural of entropy (statistics and thermodynamics), we put forwards a quantitative physics field to describe these distributions, named surface distribution entropy (SDE). Subsequently, coupling it into the MPF of electrochemistry, a new finite element analysis model (MPFCS) is developed, which can quantitatively feedback the effect of surface distribution on dendrite growth. Then we re-understand the relationship between nucleation and Li plating within this entropy involved model. In light of this, a dendrite-suppressing route was accomplished through high-density/low-size nucleation with increasing SDE. A step further, an early-warning method for Li anode was realized via the correlation between SDE and extent of dendrite.
Remote and low-cost intraocular pressure monitoring by deep learning of speckle patterns
Authors: Kalyuzhner Zeev , Agdarov Sergey , Beiderman Yevgeny , Bennett Aviya , Beiderman Yafim , Zalevsky Zeev 
Published: November 2022

Abstract
Intraocular pressure (IOP) measurements comprise an essential tool in modern medicine for the early diagnosis of glaucoma, the second leading cause of human blindness. The world's highest prevalence of glaucoma is in low-income countries.
Current diagnostic methods require experience in running expensive equipment as well as the use of anesthetic eye drops. We present herein a remote photonic IOP biomonitoring method based on deep learning of secondary speckle patterns, captured by a fast camera, that are reflected from eye sclera stimulated by an external sound wave. By combining speckle pattern analysis with deep learning, high precision measurements are possible.
The method was tested under artificially varying eye pressures on a series of 24 pig eyeballs, found to be similar to human eyes.
As a low-cost procedure, it has the potential to meet clinical needs in low- and middle-income countries and at points of care everywhere.
Evaluation of T cell responses with the QuantiFERON SARS-CoV-2 assay in individuals with 3 doses of BNT162b2 vaccine, SARS-CoV-2 infection, or hybrid immunity
Authors: Dourdouna Maria-Myrto , Tatsi Elizabeth-Barbara , Syriopoulou Vasiliki , Michos Athanasios 
Published: November 2022

Abstract
Cellular immunity after SARS-CoV-2 infection or immunization may be important for long-lasting protection against severe COVID-19 disease. We investigated cellular immune responses after SARS-CoV-2 infection and/or vaccination with an interferon (IFN)-γ release assay (QuantiFERON, QFN). In parallel, we measured SARS-CoV-2 anti-Nucleocapsid (Abs-N), anti-Spike (Abs-S) and Neutralizing (NAbs) antibodies against SARS-CoV-2 wild type and Omicron variant. We recruited 41 participants: unvaccinated children and adults and vaccinated uninfected or vaccinated convalescent adults. All vaccinated adults had received three doses of the BNT162b2 COVID-19 vaccine at 6.2–10.9 months prior to their inclusion to the study. All the unvaccinated participants were tested negative with QFN. Regarding the vaccinated population, 50% (8/16) of the vaccinated uninfected adults and 57.1% (8/14) of the vaccinated convalescent adults were tested positive. Among the QFN positive individuals, a reactive response to antigen (Ag) 1 (CD4+ epitopes) and to Ag2 (CD4+ and CD8+ epitopes), was detected in 68.8% (11/16) and 87.5% (14/16) respectively, while 56.3% (9/16) had a reactive response to both antigens. Additionally, Ag1 IFN-γ values correlated with Abs-S (P < 0.001) and NAbs against wild type (P = 0.039) levels, but not with NAbs against Omicron variant (P = 0.09) and Ag2 IFN-γ values correlated only with Abs-S levels (P = 0.009). The SARS-CoV-2 QFN assay did not detect T cellular responses in unvaccinated individuals and in a significant number of vaccinated individuals. Further comparative studies with different immunology assays are required to elucidate whether this is the result of waning immunity or low sensitivity of the assay.
Unbalanced aryl hydrocarbon receptor expression in peripheral and lesional T cell subsets of atopic dermatitis
Authors: Hu Yu-qing , Zhao Yan , Zhang Jianzhong 
Published: November 2022

Abstract
Conclusion AhR was highly expressed in subpopulations of T cells in peripheral blood and skin lesions of AD, suggesting that AhR might contribute to the pathogenesis of AD.
Background and Objective The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which is involved in the pathogenesis of a variety of skin diseases such as atopic dermatitis (AD). In this study, we aimed to study the AhR-expressing cells in T helper 17 (Th17), T helper 22 (Th22), regulatory T cells (Treg) and B cells in peripheral blood and in AD skin lesions.
Methods Twenty AD patients defined according to the Chinese criteria of atopic dermatitis and eighteen healthy subjects were included in our study. The AhR-expressing Th17, Th22, Treg and total B cells in peripheral blood was measured by flow cytometry. The AhR+ Th17 cells and AhR+ Th22 cells in AD skin lesions was measured by immunofluorescence. The mRNA of AhR, interleukin (IL)-22, IL-17A, IL-10, Foxp3, RORγT and TGF-β in peripheral blood mononuclear cells (PBMCs) was measured by real-time quantitative polymerase chain reaction.
Results The expression of AhR in peripheral CD4+ T cells, Th22 cells, Treg cells and total B cells was significantly increased in AD. AhR+IL-17A+ and AhR+IL-22+ lymphocytes were also increased in AD skin lesions. The mRNA levels of AhR, IL-22 and IL-17A in PBMCs in AD patients were significantly higher. AhR mRNA levels in PBMCs positively correlated with peripheral basophil count, peripheral eosinophils count and mRNA levels of IL-22.
Optimized geometry parameters of PMBLDC motor using Hybrid moth flame
Authors: Chandran Praveenkumar , Mylsamy Kaliamoorthy , Umapathy Prabha S 
Published: November 2022

Abstract
PMBLDC motor is a type of brushless motor with a permanent magnet as a rotor material. Its main advantage is high efficiency and high lifetime due to less friction in the operation. Its efficiency can be improved further by the proper selection of BLDC motor design. Based on that, in the existing approach, the finite element analysis (FEA) is carried out using software for finding the stator material and the number of turns. This approach provides the optimal stator material with fixed turns as PMBLDC motor design. But in this, the analysis is carried out only for the two numbers of turns only. Hence, in this, a hybrid optimization approach is proposed for designing the PMBLDC motor. The hybrid optimization selects the pole pairs, thickness winding, and other PMBLDC parameters by minimizing the power loss of the motor. To perform this, here, the moth flame and Cauchy particle swarm optimization are used to determine the optimal PMBLDC parameters using MATLAB R2020b version under a windows 10 environment. The proposed method's performance will be compared with the existing in terms of torque and power loss.
Does the dorsal plication matter with the results of primary hypospadias repair?
Authors: Wu Xuemin , Liu Zhaoquan , Wang Hongwei , He Yan , Xu Yingrui , Liu Wei , Wu Rongde 
Published: November 2022

Abstract
Objective
To evaluate the efficacy of dorsal plication (DP) to correct ventral penile curvature (VPC) in hypospadias repair with urethral plate preservation.
Materials and Methods
We conducted a chart review of all patients underwent DP during primary hypospadias repair with urethral plate preservation from January 2018 to December 2021. Patients were divided into two groups according to the curvature degree after degloving, including < 30° (group 1) and 30–45° group (group 2). The recurrent VPC, common urethral complications and pediatric penile perception score (PPPS) questionnaires from parents were analyzed.
Results
A total of 66 patients were included. There were 51 patients in group 1 and 15 in group 2. The incidence of recurrent VPC (7.8% vs 13.3%, p = 0.889) and urethral complications (66.7% vs 46.7%, p = 0.160) did not differ between the two groups. We collected 33 PPPS questionnaires. There was no significant difference in dissatisfaction evaluation with penis length between the two groups (12.0% vs 25.0%, p = 0.744 > 0.05).
Conclusions
DP did not increase the incidence of recurrence VPC and urethral complications and the dissatisfaction rate of penile length in correcting 30–45° VPC after degloving in hypospadias repair. Long term follow-up and more cases are still required for the efficacy of DP.
Viscous dissipation and Joule heating Effects on Unsteady flow of Walters-B and tangent hyperbolic liquid past a semi-infinite vertical porous plate
Authors: Pavani M. Naga , Reddy G. VenkataRamana 
Published: November 2022

Abstract

The major aim of this communications is to examine the mass and heat transport process of two non-Newtonian liquids (Walters-B and hyperbolic tangent liquid) flowing into the boundary layer through a semi-infinite upward penetrable plate. The flow analysis is governed by partial differential equations (PDEs). The PDEs are reduced by utilizing a suitable quantity to obtain set of dimensionless PDEs. The simplified equations are solved by utilizing the spectral relaxation method (SRM). SRM is a technique that solved differential equations iteratively by first decoupling the system. This communication is unique because it elucidated the simultaneous flow of two non-Newtonian liquids with flow radiation, and Joule heating, viscous dissipation, magnetic field and so on. Increasing magnetic term enhances Lorentz force and the velocity degenerates owning to the simultaneous flow of Walters-B and hyperbolic tangent liquid, increase in the Weissenberg number elevates the velocity profile. The outcomes of this agrees with previous outcomes.
Effects of climate change on livelihood strategies of farm households: the case of the Lowlands of Wolaita Ethiopia
Authors: Aboye Almaz Balta , Kinsella James , Leza Tekle 
Published: November 2022

Abstract
Climate change affects rural communities that depend on agriculture for their livelihoods. Farmer focus groups and a survey of 400 farm households were used to examine the livelihood strategies used by households in the context of a changing climate and to identify the factors that affect adoption of livelihood strategies in the lowlands of Wolaita, southern Ethiopia. The findings showed that just over half of the farm households depended solely on agricultural activities (crop and animal production) as their primary source of household income. The findings suggest that during a two-decade period, the frequency and severity of extreme weather events increased, which affected the livelihood strategies of farm households. Farmers reported that climate variability affected farming activities by decreasing yields as result of irregular and delayed rainfall as well as impaired animal productivity due to shortage of grass, inadequate water, and illnesses. This study showed that gender, age, level of education, household size, landholdings, livestock ownership, extension advisory contact, total annual income, and access to food aid were significantly affected the adoption of livelihood strategies in the area. The findings suggest that national public policy should support climate-smart agricultural practices, as well as non-farm livelihood diversification strategies, as part of Ethiopia’s national job creation strategy.
Algorithms for the diagnosis and treatment of chronic tonsillitis
Authors: Vladimirova T. Yu. , Lenshina N. Yu. 
Published: November 2022

Introduction. Features of the course of chronic tonsillitis may vary depending on the age of the patient, his comorbid status and the severity of the disease. One of the characteristic manifestations of the disease are local signs of chronic tonsillitis and manifestations of a systemic inflammatory response. The article considers the issue of increasing the effectiveness of treatment of patients with chronic tonsillitis at the stage of clinical examination by using bioregulatory therapy drugs in complex conservative treatment. Aim. Evaluation of the effectiveness of bioregulatory therapy (Traumeel ® S) in the dynamic monitoring of patients with chronic tonsillitis. Materials and methods. A randomized controlled trial was conducted in patients with newly established and confirmed diagnosis of chronic tonsillitis, decompensated form. The severity of subjective and objective symptoms was assessed using a visual analogue scale, as well as pharyngoscopy data, supplemented by the results of ultrasound examination of the palatine tonsils. Results. In the group of patients who took bioregulatory therapy, positive dynamics was observed already on the 2 nd day and related to the reduction of bad breath and sore throat. Comparative analysis in the groups made it possible to note a more significant and faster dynamics in relation to changes in the palatine arches, elasticity of the palatine tonsils and the phenomena of retromaxillary regional lymphadenitis. The monitoring of the condition of the treated patients over the course of 6 months made it possible to identify more rare recurrences of chronic tonsillitis among patients in the complex treatment of which the bioregulatory medicine was used, the frequency of which was 2.8 times lower compared to the control group. Discussion. The conducted study showed that the use of bioregulatory therapy has a positive effect on the symptoms of the inflammatory process. This is confirmed by an improvement in the general condition of patients in dynamics, a decrease in pain according to visual analogue scale, and an objective assessment of changes in the structure of the palatine tonsils using ultrasonography. Conclusions. Вioregulatory therapy as of a complex application (oral and parenteral forms) increases the effectiveness of treatment in patients of the dispensary group with a newly diagnosed chronic tonsillitis, decompensated form. Drug can significantly reduce the duration of therapy and reduce the number of relapses after complete recovery within 6 months.
Evaluation of the impact of a special sound signal on the functional state of the hearing organ (experimental study)
Authors: Dvoryanchikov V. V. , Kuznetsov M. S. , Logatkin S. М. , Golovanov А. E. 
Published: November 2022

Introduction. The integration of special acoustic means into the safety system makes it relevant to conduct biomedical research to evaluate the impact of their effects on the hearing organs. Objective. To study the characteristics of a special sound signal and its effect on the hearing organ of an experimental biological model. Materials and methods. The study was conducted on 6 males (12 ears) guinea pigs (Cavia porcellus) weighing 200–250 grams at the age of 4 weeks. A set of special audio equipment was used to generate an acoustic signal. The study was conducted in a room with an area of about 47 m2. The time of a single exposure to experimental animals was 3 minutes at a sound level of 127–128 dBA. Before exposure and at different times after exposure (after 24 and 72 hours), the otoscopic picture was evaluated, a Preyer’s reflex and distortion-product otoacoustic emissions (DPOAEs) was carried out. Results. The special sound signal was characterized by distinct frequency components and can be attributed to tonal noises. After acoustic exposure to a special sound signal, a normal otoscopic picture was observed in experimental animals. Restoration of the Preyer’s reflex occurred 24 hours after exposure. The restoration of the DPOAEs to background values at frequencies from 1.5 to 3.3 kHz occurred 24 hours after acoustic exposure, at a frequency of 4.2 kHz there was a significant tendency to recovery. Conclusions. With a short-term (within three minutes) single exposure to a special sound signal with a sound level of 127 to 128 dBA on biological models (guinea pigs), no pathology of the hearing organ was detected. Given the greater resistance of humans to acoustic effects, compared to guinea pigs, this can equally be extended to humans.
Ragweed is in the Air: Ambrosia L. (Asteraceae) and Pollen Allergens in a
Changing World
Authors: Montagnani Chiara , Gentili Rodolfo , Citterio Sandra 
Published: November 2022

Abstract:
Globally Ambrosia species (Asteraceae), commonly called ragweed, are recognized to be
one of the most problematic groups of invasive weeds and one of the main allergenic genus. Climate
and land-use change and air pollution are expected to promote ragweed spread, increase airborne ragweed
pollen concentrations (the source of allergens), extend the pollen season, and promote longdistance
transport of pollen or sub-pollen particles containing allergens. The allergenicity of pollen
itself is going to increase. Likely, all these factors will have meaningful effects in the exacerbation of
the sensitization to ragweed pollen and the severity of allergy symptoms. Globally the major health
concern regards A. artemisiifolia, because of its very wide global distribution and highly invasive behavior.
Together with A. artemisiifolia, also A. trifida and A. psilostachya are species of health concern
distributed across different continents, widespread and invasive in several regions. The present review
summarizes the characteristics of these species and gives an overview of factors contributing to their
allergenicity.
Differentiation of Clear Cell and Non-clear-cell Renal Cell Carcinoma
through CT-based Radiomics Models and Nomogram
Authors: Tuerdi Batuer , Cheng Delu , Abudikeranmu Yeerxiati 
Published: November 2022

Purpose:
The aim of the study was to investigate the feasibility of discriminating between
clear-cell renal cell carcinoma (ccRCC) and non-clear-cell renal cell carcinoma (non-ccRCC) via radiomics
models and nomogram.

Method:
The retrospective study included 147 patients (ccRCC=100, non-ccRCC=47) who underwent
enhanced CT before surgery. CT images of the corticomedullary phase (CMP) were collected and
features from the images were extracted. The data were randomly grouped into training and validation
sets according to 7:3, and then the training set was normalized to extract the normalization rule for the
training set, and then the rule was applied to the validation set. First, the T-test, T'-test or Wilcoxon
rank-sum test were executed in the training set data to keep the statistically different parameters, and
then the optimal features were picked based on the least absolute shrinkage and selection operator
(LASSO) algorithm. Five machine learning (ML) models were trained to differentiate ccRCC from noccRCC,
rad+cli nomogram was constructed based on clinical factors and radscore (radiomics score),
and the performance of the classifier was mainly measured by area under the curve (AUC), accuracy,
sensitivity, specificity, and F1. Finally, the ROC curves and radar plots were plotted according to the
five performance parameters.

Result:
1130 radiomics features were extracted, there were 736 radiomics features with statistical
differences were obtained, and 4 features were finally selected after the LASSO algorithm. In the validation
set of this study, three of the five ML models (logistic regression, random forest and support
vector machine) had excellent performance (AUC 0.9-1.0) and two models (adaptive boosting and
decision tree) had good performance (AUC 0.7-0.9), all with accuracy ≥ 0.800. The rad+cli nomogram
performance was found excellent in both the training set (AUC = 0.982,0.963-1.000, accuracy=0.941)
and the validation set (AUC = 0.949,0.885-1.000, accuracy=0.911). The random forest model with
perfect performance (AUC = 1, accuracy=1) was found superior compared to the model performance
in the training set. The rad+cli nomogram model prevailed in the comparison of the model's performance
in the validation set.

Conclusion:
The ML models and nomogram can be used to identify the relatively common pathological
subtypes in clinic and provide some reference for clinicians.