bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time Matters: A Swedish Cohort Study of Labor Duration and Risk of Uterine Rupture
Authors: Hesselman S. , Lampa E. , Wikman A. , Törn A.E. , Högberg U.L.f. , Wikström A.-K. , Jonsson M. 
Published: September 2022

(Acta Obstet Gynecol Scand. 2021;100:1902–1909)
In medium- to high-resource settings, a previous cesarean delivery (CD) is the main risk factor for uterine rupture, which is associated with maternal and neonatal morbidity and mortality. Induction of labor and augmentation of labor with oxytocin are both modifiable risk factors but are also common in patients who do not experience uterine rupture. One risk factor that could potentially help identify patients at risk of uterine rupture is slower progression in labor. This study aimed to examine the relationship between duration of labor and uterine rupture in the first trial of labor after one CD. The study also aimed to evaluate risk factors such as induction and use of prostaglandins, oxytocin, and epidural analgesia.
Effect of Educational Training on Nurses’ Ability to Care for Patients with Pressure Injuries: A Meta-analysis
Authors: Yuan Liqiong , Ye Maoting , Yang Ting 
Published: September 2022

ABSTRACT

Objective
To provide up-to-date, systematic pooled evidence on the effect of educational training on nurses’ knowledge and classification skills related to pressure injuries.

Data Sources
The authors searched the following databases: MEDLINE, EMBASE, ScienceDirect, Google Scholar, and Cochrane library.

Study Selection
Two investigators independently performed the primary screening (title, abstract, and keywords). Of the 903 articles identified, 99 studies met the eligibility criteria, and their full texts were reviewed. Of these, nine studies totaling 25,723 participants satisfied the inclusion criteria and were included in the review.

Data Extraction
Manual data extraction was performed by the primary investigator using a predefined, semistructured form and was checked for accuracy by secondary investigators.

Data Synthesis
The majority of the included studies (five out of nine) were low quality. For knowledge score, the pooled standardized mean difference was 1.60 (95% CI, 0.79–2.41), P < .001. For classification skills, the pooled risk ratio was 1.20 (95% CI, 1.12–1.28).

Conclusions
Educational training was relatively effective in improving nurses’ pressure injury knowledge and classification skills, although the studies in this review exhibited significant heterogeneity.
Sclerotherapy in Aesthetic Medicine: Myths and Realities
Authors: Liu Annie , Boen Monica , Fabi Sabrina , Goldman Mitchel P. 
Published: September 2022

BACKGROUND
Sclerotherapy is commonly performed for elimination of reticular and telangiectatic leg veins. There are several variations in practice, from the preparation to post-therapy directives.

OBJECTIVE
To critically examine the misconceptions of sclerotherapy for aesthetic indications.

MATERIALS AND METHODS
This review assesses evidence for and against each of the most common myths regarding sclerotherapy for aesthetic indications.

RESULTS
Sclerotherapy can be safely used to treat veins in areas other than the lower extremities, with the exception of the face. Laser therapy is not superior to sclerotherapy for the treatment of small telangiectatic veins on the lower extremities. The type of syringe used to produce foam sclerotherapy is an important procedural consideration. After sclerotherapy, graduated compression stocking usage is a vital part of the procedure. Detergent sclerotherapy agents are similar, but not equivalent. Touch-up treatments after sclerotherapy should not be performed for 2 months post-treatment. Foam sclerotherapy does not have a high risk for air emboli. It is not advisable to treat the leg veins in “sections.” Finally, one cannot reliably treat the telangiectatic veins without treating the feeding reticular veins for a satisfactory result.

CONCLUSION
Many aspects of sclerotherapy have existing evidence to dictate best clinical practice.
An Open-Label, Prospective, Pilot Study of Hypertonic Saline for Hidradenitis Suppurativa
Authors: Porter Martina L. , Salian Prerna , Rosales Santillan Monica , Greif Charlotte , Kimball Alexa B. 
Published: September 2022

BACKGROUND
Hidradenitis suppurativa (HS) fistulas are likely to persist without surgical intervention. Hypertonic saline (HTS), a venous sclerosant, disrupts the endothelial lining leading to occlusion and fibrosis when used for venous insufficiency.

OBJECTIVE
To evaluate the efficacy and tolerability of HTS sclerotherapy for HS fistulas.

METHODS AND MATERIALS
This Institutional review board–approved, nonrandomized, clinical trial included adult patients with a diagnosis of HS and at least one confirmed HS fistula who underwent HTS injections into their fistulas every two weeks followed by a 4-week follow-up period. The study was performed from 2016 to 2019 at two academic outpatient dermatology clinics in Boston, MA. Primary outcomes were physician-assessed improvement of HS fistula characteristics between final and baseline visits and physician-assessed HS improvement during course of study.

RESULTS
Overall, 21 patients participated. Physician-assessed overall HS improvement was significant between Visits 2 and 3 (p = .036). Drainage (p = .035), erythema (p = .008), and swelling (p = .025) demonstrated statistically significant improvement from baseline to final visit. Dermatology life quality index scores significantly improved from baseline to Visit 2 (p = .0005), Visit 3 (p = .0008), and final visit (p = .011). Numeric rating scale stinging scores increased with sclerosant volume.

CONCLUSION
This study demonstrated physician-reported and patient-reported improvement in fistulas following serial HTS injections. HTS injections were well tolerated.
Impact of 60 days of head-down bed rest on large arteries
Authors: Boutouyrie Pierre , Fayol Antoine , Fortier Catherine , Khettab Hakim , Cristian Catalin , Gencer Umit , Fouassier David , Mousseaux Elie , Derobertmasure Audrey , Leguy Carole , Bruno Rosa-Maria 
Published: September 2022

Background:
The long-term cardiovascular consequences of microgravity on large arteries are a threat for long-term space missions. We hypothesized that changes in arterial properties differ according to the arterial territory (upper or lower body), and arterial structure (elastic vs. muscular arteries), in response to 60-day head-down bed rest (HDBR).

Method:
Twenty healthy male volunteers were included and received a daily multivitamin supplementation in a double-blind fashion. At baseline, 29 and 52 days during strict HDBR, then 12 and 30 days after HDBR, aortic stiffness was measured using carotid-to-femoral pulse wave velocity (cf-PWV) and aortic MRI. Carotid, femoral, brachial and popliteal arteries were studied by ultrasound echo tracking, central blood pressure (BP) by tonometry and endothelial function by flow-mediated dilatation.

Results:
Cf-PWV increased during HDBR (+0.8 and +1.1m/s, at D29 and D52, respectively, P = 0.004), corresponding to an increase in vascular age up to +11 years (P = 0.003). Changes were similar to those observed on MRI (+0.8 m/s at D52, P < 0.01) and were independent of BP and heart rate changes. After HDBR, cf-PWV showed a substantial recovery at R12 but still remained higher than baseline at R30 (+0.8 m/s, P = 0.018), corresponding to +6.5 years of vascular aging (P = 0.018). Thoracic aorta diameter increased significantly (+6%, P = 0.0008). During HDBR, femoral and popliteal arteries showed dimensional changes, leading to femoral inward hypotrophic remodeling (femoral diameter: −12%, P < 0.05; wall cross-sectional area: −25%, P = 0.014) and popliteal inward eutrophic remodeling (popliteal diameter: −25%, P < 0.05; wall cross-sectional area: −3%, P = 0.51). After HDBR, both arterial territories of the leg recovered. We did not observe any significant changes for carotid arteries nor for endothelial function during and after HDBR. Multivitamin supplementation did not affect vascular changes. HDBR was associated with an important increase in aortic stiffness, which did not completely recover 1 month after the end of HDBR. The thoracic aorta and the lower body muscular arteries underwent significant changes in dimensions whereas the common carotid arteries were preserved.

Conclusion:
These results should raise caution for those exposed to microgravity, real or simulated.
EVALUATION OF THE RETINAL HAZARD WITH 3D DIGITALLY ASSISTED VISUALIZATION SYSTEM AND CONVENTIONAL MICROSCOPE IN MACULAR SURGERIES
Authors: Horigome Yuka , Iwashita Yume , Hirono Kazushi , Inoue Tatsuya , Konno Ami , Kadonosono Kazuaki , Yanagi Yasuo 
Published: September 2022

Purpose:
To investigate the retinal light hazard during macular surgery using a digital three-dimensional visualization system (3D) and a conventional microscope (CM).

Design:
Experimental study and retrospective evaluation of a case–control study.

Subjects:
A total of 20 and 10 patients who underwent pars plana vitrectomy for epiretinal membrane using 3D and CM, respectively.

Methods:
Spectral irradiances of endoilluminators were measured for representative settings used during core vitrectomy and macular manipulations with 3D and CM. From the medical record of the patients, time needed for core vitrectomy and macular manipulations was extracted. The total retinal light hazard index and the macular hazard index were calculated based on the spectral irradiances weighted by the standard functions. Total retinal light hazard index, macular hazard index, and the number of cases that exceeded the maximum permissible radiant power exposure were compared between the two groups.

Results:
The spectral irradiance were 1.6 and 3.9 mW/cm2 for core vitrectomy and 3.4 and 8.1 mW/cm2 for macular manipulations using typical settings for 3D and CM groups, respectively. The total retinal light hazard index ranged from 4.31 kJ/m2 to 17.37 kJ/m2 for 3D and 11.09 kJ/m2 to 27.70 kJ/m2 for CM groups, respectively, whereas the macular hazard index ranged from 2.93 kJ/m2 to 14.58 kJ/m2 for 3D and from 6.84 kJ/m2 to 23.55 kJ/m2 for CM, respectively (P < 0.001). One (5%) and 6 (60%) pars plana vitrectomy cases exceeded the threshold limits with 3D and CM groups, respectively (P < 0.05, chi-square test).

Conclusion:
The 3D digitally assisted visualization system offers significantly safer macular surgery compared with the CM, considering the potential retinal hazard.
Impact of social determinants of health on anticoagulant use among patients with atrial fibrillation: Systemic review and meta-analysis
Authors: Khatib Rasha , Glowacki Nicole , Byrne John , Brady Peter 
Published: September 2022

Background:
A growing body of literature now exists examining associations between social determinants of health (SDOH) and adverse outcomes in patients with atrial fibrillation; however, little is available on anticoagulant prescriptions and the impact of SDOH.

Purpose:
Evaluate the impact of SDOH on anticoagulant prescriptions in patients with atrial fibrillation.

Data Sources:
Medline and Embase databases up to January 2021.

Study Selection:
Noninterventional studies were included if they reported associations between at least 1 of 14 SDOH domains and anticoagulant prescription in patients with atrial fibrillation. Two investigators independently screened and collected data.

Data Extraction:
Two investigators independently screened and collected data.

Data Synthesis:
Meta-analyses using random-effect models evaluated associations between SDOH and receiving an anticoagulant prescription. We included 13 studies, 11 of which were included in meta-analyses that reported on the impact of 9 of the 14 SDOH included in the search. Pooled estimates indicate a 0.85 (95% confidence interval [CI]: 0.75, 0.97) lower odds of receiving anticoagulant prescriptions among Black compared to non-Black patients (reported in 6 studies); 0.42 (95% CI: 0.32, 0.55) lower odds of receiving anticoagulant prescriptions among patients with mental illness compared to those without mental illness (2 studies); and a 0.64 (95% CI: 0.42, 0.96) lower likelihood of receiving oral anticoagulant prescription among employed patients compared to unemployed patients (2 studies).

Limitations:
SDOH lack consistent definitions and measures within the electronic health record.

Conclusion:
The literature reports on only half of the SDOH domains we searched for, indicating that many SDOH are not routinely assessed. Second, social needs impact the decision to prescribe anticoagulants, confirming the need to screen for and address social needs in the clinical setting to support clinicians in providing guideline concordant care to their patients.

Registration:
This systematic review and meta-analysis was registered with PROSPERO.
Investigation of the effects of anti-TNF agents on hemoglobin levels in patients with inflammatory bowel disease
Authors: Okuyucu Muhammed , Avcioğlu Ufuk , Şenel Tuğba , Ustaoğlu Müge 
Published: September 2022

Inflammatory bowel disease (IBD) is characterized by many clinical features. Anemia is 1 of the most frequent complications and/or extraintestinal manifestations of IBD. There are conflicting data regarding the relationship between changes in hemoglobin levels and disease prevalence in IBD patients with and without antitumor necrosis factor (antiTNF) therapy. In our study, we aimed to investigate the long-term effect of antiTNF agents on anemia in IBD.
The records of IBD patients followed-up in our hospital between January 2011 and January 2021 were reviewed retrospectively. Demographic, clinical, endoscopic, radiological and medical treatment data of the patients were recorded. Complete blood count and laboratory markers of inflammation and disease activation, were recorded at the beginning and at the first year of treatment in all patients. The data of patients with and without antiTNF therapy were analyzed statistically. A total of 240 IBD patients who met the inclusion criteria were enrolled in the study. The number of patients with and without antiTNF therapy was 102 (42.5%) and 138 (57.5%), respectively. The change in all laboratory parameters between the beginning and the first year of treatment was statistically significant (P < .001) in all IBD patients with and without antiTNF therapy. The change in Hb level after 1 year of treatment was significantly different in patients with antiTNF therapy compared to those without therapy (3.00 ± 1.78 g/dL vs 1.19 ± 1.38 g/dL, P < .001). In the multiple regression analysis, male gender, antiTNF therapy, baseline Hb level and iron therapy were independent significant variables of hematopoietic response. This study showed that with appropriate treatment, hemoglobin levels of IBD patients with and without antiTNF therapy increased within 1 year, and the use of antiTNF agents in the treatment of IBD was an independent variable in correcting anemia.
Clinical features and characteristics of pediatric patients with COVID-19 infection: Experiences in a Tertiary Taiwan Hospital
Authors: Bai Geng-Hao , Shih Ping-Yi , Chen Shih-Yen , Hsieh Kai-Sheng , Chou Cheng-Che , Feng Po-Hao , Kong Shu-Sing , Lin Wen-Chuan , Lu Meng-Che 
Published: September 2022

Coronavirus disease 2019 (COVID-19) patients have distinct clinical features in the pediatric groups. However, there is a paucity of research focused on clinical manifestation within pediatric group in Taiwan. This study is to conduct a retrospective study of the clinical features of COVID-19 in Taiwan pediatric patients.
A retrospective study was conducted on pediatric patients (Aged ≤ 18 years) in a Northern Taiwan hospital from May 1st, 2021 to June 30th, 2021. Thirty-eight patients were included from emergency room. They were laboratory confirmed COVID-19 through specimens from nasopharyngeal swab by real-time reverse-transcription polymerase chain reaction (RT-PCR). Data including RT-PCR cycle threshold (Ct) values, clinical and epidemiological features were collected and analyzed.
Thirty-eight patients aged from 7-month to 18-year-old were included. The median age of patients was 15-year-old. The patients had sex ratio of 23 males to 15 females. More than half patients were infected from family members. Asymptomatic patients were 47.37%. In the symptomatic patients, fever (34.21%) was the most predominant symptom. Cough, nasal obstruction and sore throat were also common. Asymptomatic children had significantly higher Ct-values than symptomatic children, and diagnosed patients with Ct-values more than 19 were associated with asymptomatic infection (P = .0084).
Ct-values higher than 19 were associated with asymptomatic infection, which may be a predictor of pediatric disease severity. Our results highlight the distinct clinical manifestations and outcomes in pediatric COVID-19 patients. Compared to the adults, pediatric patients aged ≤ 18 years with COVID-19 in Taiwan mainly had mild disease.
Differences in temperament and character inventory (TCI) profile between suicidal and nonsuicidal psychiatric outpatients
Authors: Hong Sumin , Jeon Hong Jun , Ha Jee Hyun 
Published: September 2022

The purpose of this study was to identify personality traits associated with suicide attempt in a clinical sample. Temperament and character inventory (TCI) profiles of 759 patients who met the inclusion criteria among 1000 randomly selected hospital records collected. Of these 759 patients, 103 had a history of at least 1 actual suicide attempt (suicidal group) whereas 656 had no such history (nonsuicidal group). The suicidal group showed higher scores of novelty seeking (mean ± SD: 36.1 ± 1.2 vs 33.3 ± 0.5; P = .026) and harm avoidance (57.1 ± 1.5 vs 53.0 ± 0.6; P = .01) but lower scores of self-directedness (27.5 ± 1.5 vs 34.4 ± 0.6; P < .001) than the nonsuicidal group. Higher novelty seeking (OR [95% CI]: 1.031 [1.008–1.054]; P = .007) and lower self-directedness: 0.955 [0.927–0.983]; P = .002 were also associated with suicide attempts in the analysis of 7 personality scales. These findings suggest that patients who attempt suicide differ from nonattempters in terms of personality traits, especially in novelty seeking (NS), harm avoidance (HA), and self-directedness (SD). It is noteworthy that this study contains data from actual visits to the emergency room to evaluate suicide attempts.
Abbreviations: CO = cooperativeness, Ha = harm avoidance, NS = novelty seeking, PS = persistence, RD = reward dependence, SD = self-directedness, ST = self-transcendence, TCI = temperament and character inventory.
Effects of sleep insufficiency on spatial working memory in low-pressure and hypoxic environments
Authors: Li Bingqi , Dong Haotian , Wang Yanxiang , Li Fangming , Gao Xiaolei , Ma Hailin , Gao Lei 
Published: September 2022

Background:
This study aimed to investigate the effects of sleep insufficiency on spatial working memory in low-pressure and hypoxic environments.

Methods:
We selected 58 insufficient sleepers and 27 normal sleepers among the college students living in high-altitude areas for a long time to receive a spatial 2-back working memory task, while collecting behavioral and electroencephalograph data. We adopted an independent sample t-test and repeated measures analysis of variance to compare the differences in response time and accuracy, P2 and late positive potential components, and theta band energy values in the spatial working memory task between insufficient and normal sleepers.

Results:
We found no significant differences in response time and accuracy between the insufficient sleep group and the normal sleep group; however, the P2 peak value and the early theta band energy value were higher in the insufficient sleep group than in the normal sleep group.

Conclusions:
These results suggest that the spatial working memory ability of individuals with sleep insufficiency was weakened under low-pressure and low-oxygen environment.
A meta-analysis of wenxin granule and metoprolol for the treatment of coronary heart disease and arrhythmia
Authors: Meng Ling-Li , Huang Wei 
Published: September 2022

Background:
This meta-analysis aimed to systematically and comprehensively assess the effectiveness and safety of wenxin granule (WXG) and metoprolol in the treatment of elderly patients with coronary heart disease (CHD) and arrhythmia.

Methods:
We searched the electronic databases of the Cochrane Library, PUBMED, EMBASE, CNKI, Wangfang, and CBM from initiation to May 1, 2022, and selected a set of clinical indicators for WXG and metoprolol for CHD and arrhythmia. The methodological quality of the included studies was analyzed using the Cochrane risk-of-bias tool. Data were pooled using a fixed-effects or random-effects model, and a meta-analysis was conducted.

Results:
Eight randomized controlled trials involving 722 patients with CHD and arrhythmia were included. Our findings showed that WXG and metoprolol showed better effects than metoprolol alone on electrocardiogram change (odds ratio [OR] = 7.21, 95% confidence interval [CI] [1.48, 35.07]), clinical symptom improvement (OR = 5.83, 95% CI [1.52, 22.35]), overall clinical effect (OR = 5.51, 95% CI [2.65, 11.44], P < .001), atrial premature beat (mean difference [MD] = −109.85, 95% CI [−171.25, −48.46], P < .001), ventricular premature beat (MD = −195.43, 95% CI [−334.09, −56.77], P < .001), borderline premature beat (MD = −42.92, 95% CI [−77.18, −8.67], P = .01), short-burst ventricular tachycardia (MD = −35.98, 95% CI [−39.66, −32.30], P < .001), ST segment reduction (MD = −0.47, 95% CI [−0.54, −0.40], P < .001), ST segment decrease duration (MD = −0.76, 95% CI [−0.95, −0.57], P < .001). However, no significant differences were observed in adverse reactions (OR = 0.54, 95% CI [0.27, 1.09], P = .09).

Conclusion:
Compared to metoprolol alone, WXG and metoprolol can more effectively manage patients with CHD and arrhythmia. However, additional large-scale, multicenter, rigorous, and high-quality randomized controlled trials are warranted to verify the present findings.