bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological Characteristics and Prognosis of 103 Cases of CRKP in a General Hospital in Guangzhou
Authors: Zu Shuai , Zhao Hengrui , Wen Minghui , Zheng Lei , Hu Xiumei 
Published: October 2022

Abstract
Objective: To analyze the nosocomial infection of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the prognosis of patients in a general hospital in 2021.
Methods:Using unified diagnostic criteria, 103 cases of CRKP infection in a general hospital in 2021 were investigated, including the clinical epidemiological data of age, sex, and department, and the characteristics of department distribution, infection site, population and prognosis of CRKP were analyzed.
Results:As global bacterial resistance rises and widely distributed multiple drug-resistant bacteria, XDR gradually becomes untreatable, which leads to an increase in the number of hospital infections. Through the investigation of hospital infection in clinical departments and related disease areas of our hospital, it was found that the majority of clinical departments have detected multidrug-resistant bacteria, which makes us pay more attention to this phenomenon: A total of 106 strains of CRKP were detected in the whole year (repeated detection of CRKP in different specimens from the same patient was only recorded for the first time). The detection rate of CRKP in hospitals was 13.77%, and male patients were far higher than female patients. The internal medicine unit was the department with a high incidence of CRKP infection. After CRKP infection, 70 patients improved, while 33 patients did not improve (χ2= 9.936, P < 0.01).The main source of specimens and sites of infection is the respiratory tract and lungs.
Conclusion: The high-risk population of hospital CRKP infection is male elderly patients, the high-risk department is internal medicine, and the main infection site is the lung. The majority of CRKP patients improved after treatment. Tigecycline and cephalosporins enzyme inhibitor compound preparations are effective in the treatment and prognosis of clinical patients with CRKP infection.
Non-aromatic 1,3-Disilapyrroles:
a class of stable organosilicon-based triplet diradicals
Authors: Xiong Yun , Dong Shicheng , Yao Shenglai , Lorent Christian , Krause Konstantin , Gonela Vijaykumer , Zhu Jun , Limberg Christian , Driess Matthias 
Published: October 2022

Abstract
Open-shell molecules with unpaired electrons and a high-spin S ≥ 1 configuration are of fundamental importance in chemistry, biology and towards molecular electronics. Among metal-free systems, carbon- and silicon-based triplet diradicals with two unpaired electrons and strong ferromagnetic coupling are proposed as key intermediates in many organic and elementorganic transformations but their isolation remains challenging due to their very high reactivity. Herein, we report the facile synthesis of the first isolable 1,3-disilapyrroles which represent organosilicon-based delocalized triplet diradicals. They result from click chemistry of two divalent silicon atoms in a 1,1-bis(silylenyl)aniline to the carbon-carbon triple bond of diphenylacetylenes. Remarkably, the spin-density distribution of these triplet diradicals exhibits an asymmetric delocalization due to steric congestion. The unpaired electrons in the 1,3-disilapyrroles enable an unprecedented reactivity, including cyclotetramerization and complete cleavage of the carbon-oxygen triple bond of CO at ambient temperature with subsequent C(sp3)-H bond activation to give a new bicyclic product.
Factors Associated with Exclusive Breastfeeding of Children Under 6 Months of Age in Cote D'ivoire
Authors: KOFFI Ibrahima , ESSIS Esme Marie Laure , BAMBA Iba , ASSI Kaudjhis RH , KONAN Loukou Léandre , Aka Joseph 
Published: October 2022

Abstract
Introduction:
Despite benefits of exclusive breastfeeding (EBF) and its strategic place in the national guidelines for infant and young child feeding, its practice remains insufficient in Côte d'Ivoire (34%). It is therefore important to identify its early stopping associated factors.
Objectives
(i) To assess the extent of children’s exposure to exclusive breastfeeding (EBF) and the associated explanatory factors for discontinuation before 6 months. (ii) To profile non-exclusively breastfed children and interrelationships between these factors.
Materials and methods
A secondary analysis of data from the 2016 Cote d’Ivoire Fifth Multi indicator Cluster Survey (MICS5) of 980 children under 6 months of age was conducted in this study. Data were analyzed using the actuarial method of survival function estimation combined with the Wilcoxon (Gehan) test, discrete-time logistic regression, and Multiple Correspondence Factorial Analysis (MCA) to profile the children.
Results
Maternal exposure to medical discourse, age at delivery, and child sex were significantly associated with the likelihood of discontinuing EBF before the first 6 months of life. Children deprived of AME resided in urban areas, in high and very high economic welfare households. Their mothers had a secondary education or higher and were poor with up to three children. In addition, the explanatory factors for dropping out of the EBF, ranked in descending order of explanatory power, were region of residence, child's health status, household standard of living, child's gender, mother's exposure to medical discourse, and mother's education level.
Conclusion
Improving the practice of EBF in Côte d'Ivoire requires strengthening the capacities of health professionals in terms of advice and assistance to mothers for the practice of AME and its maintenance until 6 months of age, regardless of the health status and sex of the child.
Spontaneous rupture of a small intestinal stromal tumor and causes acute abdomen: a case report
Authors: zongyao chen , shuangya deng , xiaoxin jin , yuhang liu , weidong chen 
Published: October 2022

Abstract
Small intestinal stromal tumors (SIST) reports were not uncommon; however, spontaneous rupture of SIST resulting in the acute abdomen and requiring emergency surgery was uncommon. Here, we reported a case of SIST spontaneous rupture that caused an acute abdomen. The patient went to the Second Xiangya Hospital of Central South University due to abdominal pain for two days. According to his symptoms, signs, and imaging examinations, the preliminary diagnoses were "abdominal pain investigation cause" and "acute peritonitis.” Emergency laparotomy revealed an outgrowing 5-cm tumor in the ileum. The surface of the mass had ruptured, and blood clots and intestinal contents were flowing out. Postoperative pathological outcomes were considered high-risk SIST. In this paper, a literature review of this case was carried out to improve clinicians' understanding of SIST and reduce misdiagnosis and missed diagnoses.
The effects of different levels of sodium diformate on growth performance, Immunological respond, digestive enzyme activity and intestinal histomorphology
Authors: kazemi Mohsen , mohammadian Takavar , Mesbah Mehrzad , Basir Zahra , Khosravi Mohammad , Tabandeh Mohammad Reza 
Published: October 2022

Abstract
Sodium diformate (NaDF) is organic acids that modulate growth performance, Immunological respond, digestive enzyme activity and intestinal histomorphology status. So, the present study aimed to investigate the effects of different levels of NaDF on growth performance, Immunological respond, digestive enzyme activity and intestinal histomorphology in juvenile Siberian Sturgeon Acipenser baerii. Juvenile Siberian Sturgeon fed control food or diet supplemented with different levels of NaDF (0.05, 0.1 and 0.15 g/Kg) for 60 days. The results showed that NaDF 0.1 improved significantly (p < .05) fish growth performance following 30 days of application (p < .05). The results showed that dietary administration of NaDF significantly (p < .05) increased digestive enzymes. Dietary administration of NaDF in all treatments significantly increased the serum lysozyme and complement activity, and respiratory burst activity in A. baerii at days 60th of the experimental period. The highest bactericidal activity (P < 0.05) was observed in the fish which fed diet containing 0.15% NaDF (at days 30th ) and 0.1% NaDF (at days 60th ). The fishes fed diets supplemented with NaDF like other trail factor, presented increase in the thickness of the epithelium of the intestine, villus height, villus width, and number of goblet cells, were greatest in 0.15% NaDF, and followed by 0.1% NaDF after day 30 and 60 of culture. The present results revealed beneficial effects of 0.1 g/Kg dietary NaDF on growth performance and physiological response of A. baerii for 60 days.
Practice Patterns of Physical Therapists and Physical Therapist Assistants Treating Patients with Breast Cancer Related Lymphedema
Authors: Wampler Meredith , Campione Elizabeth , Bolch Charlotte A. 
Published: October 2022

Abstract
Purpose
The purpose of this study is to describe practice patterns of physical therapists (PT) and physical therapist assistants (PTA) who treat patients with breast cancer-related lymphedema (BCRL) and determine if they are adherent to best evidence recommendations for lymphedema diagnosis and intervention.
Methods
An electronic survey to collect practice pattern data of PTs and PTAs who treat patients with BCRL was distributed. A descriptive and quantitative statistical analysis was performed.
Results
26% of respondents read the American Physical Therapy Association sponsored lymphedema diagnosis clinical practice guideline (CPG) and 20% read the lymphedema intervention CPG. Lymphoscintigraphy was the only diagnosis or intervention tool with a significant difference in use between therapists who read versus did not read the CPGs. Adherence to “should do” recommendations was variable: bioimpedance (18.2%), volume calculation (49.3%), ultrasound (0%), patient reported outcome tools (64.9%), compression garments (43.9%), exercise (87.2%), and compression bandaging (56.8%).
Conclusions
There is variability in adherence to recommendations for both the lymphedema diagnosis and intervention CPGs. Interventions to improve implementation and adherence to CPG recommendations are warranted.
Influence of VR-based Brain-Computer Interfaces Training in Brain Activity and Clinical Outcome in Chronic Stroke: A Longitudinal Study of Single Cases
Authors: Vourvopoulos Athanasios , Blanco-Mora Diego , Aldridge Audrey , Jorge Carolina , Fernandes Jean-Claude , Figueiredo Patrícia , Badia Sergi Bermúdez i 
Published: October 2022

Abstract
Background: Restorative Brain-Computer Interfaces (BCI's) can provide an alternative non-muscular channel for patients who lack volitional movement by reinforcing the modulation of sensorimotor rhythms through motor-imagery (MI). MI practice can be augmented through embodied feedback delivered by virtual reality (VR). Nonetheless, detailed information concerning the impact of VR-BCI training in clinical outcome is still largely missing. This paper investigates the long-term effect of VR-BCI training in brain activity patterns measured by the electroencephalogram (EEG) and clinical scales of stroke patients.
Methods: Four chronic stroke patients underwent a 3-week VR-BCI intervention. Fugl-Meyer Assessment (FMA) was conducted pre-, post- intervention, and a follow-up, one-month later. The VR-BCI training consisted of a bimanual rowing task (NeuRow) involving MI and motor observation. From the EEG, the Event-related Desynchronization (ERD) was extracted from the Mu band (8-12 Hz). Finally, the BCI performance was computed from the BCI training session.
Results: All patients showed significantly increased Mu ERD compared to baseline, however, the affected side showed reduced ERD during the contralateral MI. Significant ERD differences originating from both the lesioned and the healthy hemisphere were found when comparing post- with pre- intervention in all patients, and decreasing ERD was found for patients with no clinical improvement. Patients with decreased lateralization of ERD had no improvement of the FMA score.
Conclusion: Stroke patients in the chronic phase can modulate their brain activity patterns using MI in a VR-BCI task, with observable patient-specific differences between brain activity and clinical outcome. Nonetheless, only patients with increased ERD lateralization showed clinical improvement.
IGSF6 is a novel biomarker to evaluate immune infiltration in mismatch repair-proficient colorectal cancer
Authors: Xu Yu-cheng , Yu Zhao-liang , Chen Xiao-chuan , Zhong Min-er , Liang Yu-fan , Weng Jing-rong , Luo Dan-dong , Bie Yi-ran , Chen Xi , Cai Jia-wei , Rong Yu-ming , Zou Yi-feng 
Published: October 2022

Abstract
Background：Immunotherapy has dramatically changed the landscape of treatment for colorectal cancer (CRC), but there is lack of effective predictive biomarker, especially for tumors with mismatch repair (MMR) proficiency. Immune response relies to cell surface receptors and their interactions, such as cell-cell recognition, binding and adhesion. However, the function of immunoglobulin superfamily (IGSF) genes in tumor immune microenvironment remains uncharacterized.
Methods: This study quantified the immune using the gene expression matrix obtained from the public database. Also the associations between IGSF6 gene expression and immune cell infiltration were assessed. The expression levels of IGSF6, CD8+ and CD4+ T cells in cancer tissues from CRC patients were evaluated.
Results: IGSF6 was more highly expressed in CRC tumor tissues than corresponding adjacent normal tissues. And IGSF6 was significantly correlated with immune cell infiltration in MMR-proficient patients. Remarkably, MMR-proficient patients with high IGSF6 expression showed more sensitive to immunotherapy and chemotherapy than those with low IGSF6 expression.
Conclusions: In summary, IGSF6 could be a novel biomarker to evaluate immune infiltration and predict therapeutic effect for MMR-proficient CRC.
Diagnostic yield of copy number variation sequencing in fetuses with increased nuchal translucency: A retrospective study
Authors: xiao yang , Bian Xinyi , Shi Xinwei , Ding Jianlin , Tang Hongju , Xu Peng , Deng Dongrui , Zeng Wanjiang , Chen Suhua , Qiao Fuyuan , Feng Ling , Wu Yuanyuan 
Published: October 2022

Abstract
Objective
To assess the clinical application value of copy number variation sequencing (CNV-seq) combined with karyotype analysis in prenatal diagnosis of fetuses with increased nuchal translucency.
Methods
205 fetuses who were diagnosed with increased nuchal translucency (NT ≥ 2.5 mm) by ultrasound between gestational ages of 11 and 13 + 6 weeks from June 2017 to December 2020 in Tongji Hospital were enrolled. Amniotic fluid samples were extracted for performing karyotype analysis and CNV-seq after patient’s written informed consent was obtained.
Results
Chromosome abnormalities were discovered in 40 fetuses (19.51%) with increased NT by karyotype and the trisomy 21 was the most common. 50 fetuses (24.39%) with chromosomal abnormalities were detected by CNV-seq, producing an incremental yield of 6.06% (10/165) in fetuses with increased NT and normal karyotype. The prevalence of chromosome abnormality increased by from 13.64% for those with NTs of 2.5–3.4 mm to 38.64% for NTs of 3.5–4.4 mm and 51.72% for NTs of over 4.5 mm. The difference had statistically significance (P < 0.05). Those with increased NT complicated with ultrasound soft markers or high risk of non-invasive prenatal testing showed higher rate of chromosome abnormality than those with isolated NT or low risk, and difference had statistically significance (P < 0.05).
Conclusion
As the thickness of NT increases, the odds of chromosome abnormalities also increase, which could be detected by karyotype or CNV-seq, and the combination application of two tests can greatly shorten the turnover time of prenatal diagnosis and the occurrence of missed diagnosis. Besides, we recommend that the NTs of 2.5-3.4mm should be considered as a critical risk range of chromosome abnormality and attention should be paid to those fetuses whether complicated with other ultrasound soft markers or not.
Using Toeplitz Matrices to obtain 2D convolution
Authors: Gnacik Michał , Łapa Krystian 
Published: October 2022

Abstract
Optimising the discrete convolution operations is important due to the fast growing interest and successful applications of deep learning to various fields and industries. In response to that, we propose an algorithm that views the 2D convolution operation between matrices as a matrix multiplication that involves a Toeplitz matrix; our algorithm is based on the mathematical result that we prove. We will present the complexity of the resulting algorithm and benchmark it against other 2D convolution algorithms in known Python computational libraries. The current implementations of our algorithm suggest a potential speed-up of convolution operation if the sparsity of the Toeplitz matrix was utilised.
Natural Resource Extraction, Ecosystem Services and Population Health: An Empirical Test of 170 Countries, 1990-2019
Authors: de Soysa Indra , Parau Cristina 
Published: October 2022

AbstractMany argue that natural resource use and degradation of ecosystems reduce human health. Others prioritize economic development for increasing human health and wellbeing, acknowledging that some environmental assets are necessarily sacrificed for human development. Neo-Marxists and other critical theorists argue that extraction of natural resources are indirect forms of exploitation of the poor, where the rich benefit while the poor sacrifice their natural capital. We test these large propositions using several measures of natural resource extraction and country-level indicators of ecosystem health on health-adjusted life expectancy (HALE) for 170 countries over a 30-year period. The results suggest that resource extraction has very little effect on population health, except that mineral resource extraction improves human health. Ecosystem services generally do not matter, but there is evidence to suggest that lower availability of biome associates with better human health, suggesting that human health is generated by factors quite independent of available biodiversity and protected area. Indeed, per capita income levels show the most robust relationship with healthy life expectancy, as does population density, results generally at odds with neo-Malthusian explanations about people, planet, and human wellbeing. Our results, taken together, support the view that development generates better human health, and perhaps as a result, spurs local-level environmental protections.
Window on Bacillus maritimus MSM1 Exopolysaccharide Characterization and Possibility of its Anti-Alzheimer Property in In-Vitro Model
Authors: El-Newary Samah , Mohamed Sahar S , Mahmoud Manal , Ibrahim Abeer , El-Newary Samah , Awady Mohamed S. El 
Published: October 2022

Abstract
Four bacterial isolates were obtained from marine sediments, collected from Sahl Hashish, Hurghada Red Sea, Egypt. The four isolates were screened for exopolysaccharides (EPS) production and acetylcholinesterase inhibition. The most promising isolate S16 provided the highest EPS yield (7.51 g/L) and acetylcholinesterase inhibition was identified morphologically and genetically using 16S rRNA gene sequence analysis as Bacillus maritimus. Physico-chemical analysis of BMEPS using UV-Vis was estimated uronic acid and sulfate contents to be 24.7% and 18.3%, respectively. HPLC analysis indicated that it Mannuronic acid, glucouronic acid, glucose, and mannose are present in a molar ratio of 0.8:1.0:2.8:2.3, respectively. Further, FT-IR showed the abundance of β-configurations. The GPC estimated the average molecular weight (Mw) to be 4.31´104 g/mol. BMEPS successfully inhibited AChE (IC50; 691.77± 8.65μg/ ml), BuChE (IC50; 288.27±10.50μg/ ml), and tyrosinase (IC50; 3.34±0.09, 14.00± 0.14, and 22.96 ± 1.23μg/ ml during incubation durations of 10, 20, and 40 minutes); It also demonstrated a selective anti-inflammatory action against COX-2 rather than COX-1. Furthermore, BMEPS showed powerful antioxidant capabilities such as free radical and oxygen reactive species (ROS) scavenging, metal chelation, reduction capacity, and suppression of lipid peroxidation. These activities are due to its distinct chemical composition, which includes sulfated moieties (18.30%) and uronic acids (24.70%). The findings of this study indicate that BMEPs shown promising anti-disease Alzheimer's activity in vitro, qualifying them for inclusion in advanced preclinical studies for the discovery of alternative treatment.
Automorphisms of affine Veronese surfaces
Authors: Aitzhanova Bakhyt , Umirbaev Ualbai 
Published: October 2022

Abstract
We prove that every derivation and every locally nilpotent derivation of the subalgebra K[xn, xn−1y, . . . , xyn−1, yn], where n ≥ 2, of the polynomial algebra K[x, y] in two variables over a field K of characteristic zero is induced by a derivation and a locally nilpotent derivation of K[x, y], respectively. Moreover, we prove that every automorphism of K[xn, xn−1y, . . . , xyn−1, yn] over an algebraically closed field K of characteristic zero is induced by an automorphism of K[x, y]. We also show that the group of automorphisms of K[xn, xn−1y, . . . , xyn−1, yn] admits an amalgamated free product structure.
Mathematics Subject Classification (2020): 14R10, 14J50, 13F20.
Resveratrol improves the progression of osteoarthritis by regulating the SIRT1-FoxO1 pathway-mediated cholesterol metabolism
Authors: Liang ChuanCai , Xing Hengte , Wang ChenYu , Xu XiongFeng , Hao Yarong , Qiu Bo 
Published: October 2022

Abstract
Osteoarthritis (OA) is considered a metabolic disorder. This study investigated the effect of resveratrol (RES) on cholesterol accumulation in osteoarthritic articular cartilage via the SIRT1/FoxO1 pathway. Interleukin (IL)-1β-treated chondrocytes that mimic OA chondrocytes were used in in vitro experiments. The optimal RES concentration was selected based on the results of chondrocyte proliferation in the Cell Counting Kit-8 assay. Western blotting, immunofluorescence, and reverse transcription-quantitative polymerase chain reaction were performed. For the animal experiments, rats were randomly divided into the RES group (n = 15), medial meniscus destabilization group (n = 15), and Sham group (n = 15), and each group received the same dose of RES or saline. Articular cartilage tissue was obtained eight weeks after surgery for relevant histological analysis. Clinical tissue test results suggest that downregulation of the SIRT1/FoxO1 pathway is associated with cholesterol buildup in OA chondrocytes. For the in vitro studies, RES increased SIRT1 expression and FoxO1 phosphorylation in IL-1β-treated chondrocytes, promoted the expression of cholesterol efflux factors (LXRα, ABCA1, and ApoA1), and inhibited the expression of cholesterol synthesis-related factors (SREBP-2and HMGCR). This reduced IL-1β-induced chondrocytes cholesterol accumulation. SIRT1 inhibition prevented the RES-mediated reduction in cholesterol buildup. Inhibiting FoxO1 but not SIRT1reduced FoxO1 phosphorylation and increased cholesterol buildup in cultured chondrocytes. Additionally, in vivo experiments have shown that RES can alleviate cholesterol buildup and pathological changes in OA cartilage. Our findings suggest that RES regulates cholesterol buildup in osteoarthritic articular cartilage via the SIRT1/FoxO1 pathway, thereby improving the progression of OA.