bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries
Authors: Iznak A. , Iznak E. , Oleichik I. , Zozulya S. 
Published: September 2022

IntroductionNon-suicidal self-injurious behavior (NSSI) is rather widespread in adolescents, especially in females, and is an important risk factor for future suicide. The search for neurobiological markers of NSSI is therefore an actual medical and social problem.ObjectivesThe aim of the study was to determine the relationships between pre-treatment quantitative clinical, EEG, and neuroimmunological parameters in female depressive adolescents with NSSI.Methods40 female depressive patients (all right-handed, 16–25 years old, mean 17.6±2.2 years old) were included in the study. Total HDRS-17 scores varied from 14 to 38 (mean 26.0±6.9). Multichannel eyes closed resting EEG was recorded with subsequent spectral power (SP) measurements in narrow frequency sub-bands. Enzymatic activities of leukocyte elastase (LE) and its antagonist α-1 proteinase inhibitor (α1-PI), as neuroinflammation markers, and the levels of autoantibodies to S100b protein (AAB-S100b) and to basic myelin protein (AAB-BMP), as neuroplasticity markers, were measured in the blood plasma. Spearman’s rank correlations were calculated between clinical, EEG, and neuroimmunological parameters.ResultsHDRS-17 scores correlated positively (p<0.05) with beta2 (20-30 Hz) SP in the right anterior and mid-temporal leads. AAB-S100b values correlated positively with alpha2 (9-11 Hz) and alpha3 (11-13 Hz) SP in central-temporal-parietal-occipital leads, and correlated negatively with beta1 (13-20 Hz) and beta2 SP in the right anterior temporal lead.ConclusionsThe structure of clinical–neurobiological correlations obtained indicates that processes of neuroinflammation in depressive adolescents with NSSI are relatively mild and/or compensated by anti-inflammatory mechanisms. The study supported by RBRF grant No.20-013-00129a.DisclosureNo significant relationships.
The UK AVATAR 1 and 2 Trials for People with Distressing Voices – Findings and Learning from AVATAR1, and AVATAR2 Developments in Theory and Therapy
Authors: Craig T. , Garety P. , Ward T. , Edwards C. , Rus-Calafell M. , Huckvale M. , Emsley R. 
Published: September 2022

IntroductionMany people suffering from psychotic disorders report persistent auditory verbal hallucinations (‘voices’) despite pharmacological and psychological therapy. Interest is growing in approaches that emphasise the personal relationship between the patient and their voice(s). AVATAR therapy is one such approach that uses a digital representation (avatar) of a selected voice to facilitate a three-way discussion between patient, therapist and voice, the therapist speaking either as him/herself or in the digitally transformed voice of the avatar. Objectives: To describe AVATAR therapy and an ongoing multi-centre clinical trial. Methods: Encouraging findings from an earlier controlled trial (AVATAR1) comparing AVATAR therapy and supportive counselling informed our current multi-site cost-effectiveness trial of brief and extended versions of the therapy compared to treatment as usual (AVATAR2). Results: AVATAR1 delivered in 7 weekly sessions resulted in a reduction in the frequency, distress and power of voices that was significantly superior to supportive counselling. Clinical experience suggested that some participants improved in response to the early focus on anxiety while others seemed more responsive to later more formulation-driven approach. These findings led us to the current ongoing three arm clinical trial comprising a brief (6 session) focus on anxiety/assertiveness, an extended (12 session) formulation-driven approach both approaches compared to treatment as usual. Conclusion: Previous AVATAR studies suggest this is a therapy with considerable promise. It can be delivered through widely available laptop computers, usually in clinic but also remotely via existing commercial platforms. The current trial will address questions about dissemination, training and cost-effectiveness in NHS settings.DisclosureThe digital technology employed in AVATAR therapy is provided by licence for the trial from Avatar Therapy Ltd
Mother-Baby Day Hospital (MBDH): preliminary results of effectiveness of multidisciplinary intensive intervention for women with postpartum affective/anxiety disorder
Authors: Gelabert E. , Torres Giménez A. , Andrés-Perpiñá S. , Naranjo C. , Roda E. , Garcia-Esteve L. , Roca Lecumberri A. 
Published: September 2022

IntroductionWomen experiencing postpartum mental illness have unique needs. Psychiatric Mother Baby Units (MBUs) can provide specialist in-patient care for mothers without separation from their baby. Since 2018, an innovative Mother-Baby Day Hospital (MBDH) have been developed and implemented in a public hospital in Spain, directed at the intensive, integral, and multidisciplinary treatment.ObjectivesThe aim of the present study was to obtain preliminary data regarding its effectiveness in postpartum women with affective and anxiety disorders.MethodsThirty-three mothers and their babies with affective or anxiety disorders attended to MBDH CLINIC-BCN participated in the study. All women were assessed at admission, discharge, and 3 months follow-up. Primary outcomes were depression (EPDS) and anxiety symptoms (STAI-S), mother-infant bonding (PBQ) and functional impairment (HoNOs).ResultsAt discharge, 100% of women no longer met the full criteria for the main diagnosis (PSR≥5). Significant improvements from admission to discharge were achieved in depression and anxiety symptoms, mother infant bonding and functional impairment. Clinical significance was also calculated. After treatment, mothers had greater autonomy for care their babies. Similar results were observed at 3 months follow-up. The MBDH was rated by mothers as an excellent quality program and they would recommend it.ConclusionsThis study found that multidisciplinary intervention at MBDH for postpartum women with affective or anxiety disorders is effective, not only for maternal psychopathology but also for maternal care and bonding. It is imperative to develop specialized devices that integrate the care of the dyad by professionals specialized in perinatal mental health.DisclosureNo significant relationships.
EEG alpha band functional connectivity and network structure mark hub overload in Mild Cognitive Impairment during memory maintenance
Authors: Fodor Z. , Horváth A. , Hidasi Z. , Gouw A. , Stam C. , Csukly G. 
Published: September 2022

IntroductionWhile decreased alpha-band functional connectivity (FC) and changes in network topology have been reported in Alzheimer’s disease, it is not yet entirely known whether these differences mark cognitive decline in the early stages of the disease.ObjectivesOur study aimed to analyze EEG FC and network differences in the alpha frequency band during visuospatial memory maintenance between Mild Cognitive Impairment (MCI) patients and healthy elderly with subjective memory complaints.MethodsFC and network structure of 17 MCI patients and 20 control participants were studied with 128-channel EEG during a visuospatial memory task. FC was measured by amplitude envelope correlation with leakage correction (AEC-c), while network analysis was performed by applying the Minimum Spanning Tree approach.ResultsIncreasing memory load enhanced the mean alpha-band FC in the control group. In contrast to that, after an initial increase, the MCI group showed significantly (p<0.05) diminished FC in the highest memory load condition. Mean alpha AEC-c correlated significantly with the size and mean diffusivity of medial temporal lobe structures in the entire sample. The network analysis revealed a rerouted network in the MCI group with a more centralized topology and a more unequal traffic load distribution compared to the control group.ConclusionsAlpha-band FC correlates with cognitive load-related modulation, with medial temporal lobe atrophy, and with the disruption of hippocampal fiber integrity in the earliest stages of cognitive decline. The more integrated network topology of the MCI group is in line with the “hub overload and failure” framework and might be part of a compensatory mechanism.DisclosureNo significant relationships.
Qualitative description of work of a psychotherapy group in the context of COVID pandemic
Authors: Najbar I. , Guśtak E. , Młynarczyk R. , Łopalewska D. 
Published: September 2022

IntroductionCOVID pandemic very much influenced therapeutic organisation of psychiatric care. This also applies to our hospital. Especially therapeutic activities in stationary wards.ObjectivesWe would like to show changes occurring in psychotherapy group of the patients with psychotic disorder in the stationary ward in core of pandemic.MethodsI would like to present a qualitative description of psychotherapy group in the context of COVID. The group is designed for patients with experience of psychosis, grounded in psychodynamic school and has a long tradition at an acute admission in stationary psychiatric department.ResultsDuring the pandemic there were epidemiological constraints. From six members of personnel in the basic assumptions, we reduced to minimum. So from two co-therapists, reflecting team and an observer, we ended leading the group every second time with one of the therapists. Despite of our efforts to maintain a continuous group, the group was closed for more than half a year and then reactivated based on old rules and roots, but less consistent memory of group members. During this most strict reduction of personnel, which would never have been accepted apart from the pandemic restrictions appeared a few interesting phenomenon. One of them was - twin groups. With the colleague we lead the group every second time. The group shows us a similar picture twice.ConclusionsAs we understand, twin groups is a way to try to keep this group together in its already damaged setting. For the moment the abstract submission group is continuing to work within its present arrangement.DisclosureNo significant relationships.
Successful mentalizing in schizophrenia is associated with specific recruitment of ventromedial prefrontal cortex and precuneus
Authors: Jáni M. , Gajdoš M. , Ustohal L. , Hořínková J. , Kašpárek T. 
Published: September 2022

IntroductionPatients with schizophrenia have difficulties in cognitive and affective mentalizing which is manifested by excessive (‘overmentalizing’) or defective (‘undermentalizing’) attribution of mental states. As most of the tests does not differentiate between ‘overmentalizing’ and ‘undermentalizing’, it is not yet clear how are these deficits reflected in mentalizing network in schizophrenia.ObjectivesInvestigate how is cognitive and affective ‘overmentalizing’ and ‘undermentalizing’ reflected in mentalizing network in schizophrenia.MethodsWe recruited 30 schizophrenia patients and 30 healthy controls who underwent fMRI session while they completed ‘Social situations assessment task’ consisting of 90 stories with 30 questions on affective, 30 on cognitive mental states and 30 control memory questions and 4 possible answers: no mentalizing, undermentalizing, appropriate mentalizing, overmentalizng (for control condition 1 correct and 3 incorrect).ResultsOn a behavioral level, we found increased no mentalizing and undermentalizing and decreased mentalizing in patients, but no difference in overmentalizing between groups. For fMRI results, patients showed lesser recruitment of dorsomedial prefrontal cortex and temporal poles (with right superior temporal sulcus) only during appropriate mentalizing in both affective and cognitive conditions. However, ventromedial prefrontal cortex and precuneus showed increased pattern of activation across all mentalizing levels in healthy controls compared to schizophrenia, but suppressed activation in appropriate cognitive mentalizing corresponding to the level of a schizophrenia group.ConclusionsSchizophrenia patients show different pattern of mentalizing compared to healthy control that can be associated with specific activity mentalizing brain network.DisclosureNo significant relationships.
The role of social intelligence and creativity as personal resources for coping with uncertainty during primary career self-determination in late adolescence
Authors: Chesnokova O. , Churbanova S. , Molchanov S. , Markish O. 
Published: September 2022

IntroductionSocial intelligence (SI) and creativity (Cr) are resources to develop adaptive coping strategies and positive emotions that can help combat feelings of fragility and vulnerability caused by uncertainty during primary career self-determination as the developmental task in late adolescence.ObjectivesThe aim of the study was to compare SI and Cr of students with high and low level of tolerance for uncertainty (TU) during two last years in the middle school.MethodsParticipants were 200 students (15-17 years old). The level of TU was estimated by Budner’s scale (Kornilova, 2010). Social intelligence was assessed by O’Sullivan & Guilford’s Tests, creativity was measured by CAP. In addition, we estimate career adapt-abilities applied to present and prospective future career decisions.ResultsTwo contrast clusters based on TU level were analysed. The level of SI and Cr were various within each group. There appears to be an association between TU and career adapt-abilities (at r ∼ .37, p < .05). Mostly female students with low level of TU and above average scores on SI and Cr demonstrate the effective coping strategy dealing with stress (at r ∼ .45, p < .01) emotionally focus on nearest professional future, seek social support. Coping strategy of students with high TU, SI and Cr is focusing on nearest and distant professional future, on task-oriented content and the social status of the future profession. They are open to new career experience and flexibility in the use of future professional skills (at r ∼ .56, p < .001).ConclusionsEmploying their SI and Cr give new opportunities to understand and prevent the development of stress and provide age-specific support to prospective students during primary career self-determination.DisclosureResearch is supported by the Russian Humanitarian Research Foundation, project No. 18-013-01067.
Impact of COVID-19 pandemic on the Acute Confusional Syndrome by the liaison psychiatry service of Hospital del Mar
Authors: Calls M. , Llimona González A. , Dinamarca F. , García Hernández D. , Oller Canet S. 
Published: September 2022

IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has had a profound worldwide impact on health. Acute Confusional Syndrome (ACS) is the most common neuropsychiatric complication in COVID-19 infection.ObjectivesDescribe the characteristics of the admited patients attended by the liaison psychiatry service for acute confusional syndrome during the COVID 19 pandemic. Sociodemographical and clinical variables were descrived.MethodsWe conducted an observational, descriptive study. All patients attended by the liaison psychiatry service of Hospital del Mar, between February and April 2020, with ACS diagnosis were included.ResultsWe included 62 patients with acute confusional syndrom; 35 were men (56.5%), and mean age was 71.71 years (standard deviation [SD]:11.345). The mean duration of admision stay was 41.19 days [SD: 38.039]. The mean number of consultations carried out was 6.5 [SD: 5.422]. 52.5% of our sample of our sample had confusional symptoms for 8 days. 50 patients presented complications during admission (80.6%), of which 43 patients developed infectious complications (69.4%). 59 patients had a history of chronic diseases (95.2%). 54 patiens (88.5%) had potencial risk factors associated with acute confusional syndrome including: isolation in 24 (39.3%), active infection in 46 (74.2%), hypoxemia in 25 (40.3%), previous cognitive impairment in 15 (24.6%)ConclusionsAcute Confusional Syndrome mainly affects people with risk factors such as isolation, active infection and hypoxemia (which in turn are symptoms of Covid-19).DisclosureNo significant relationships.
Ethnic inequalities in multiple comorbidities among people with psychosis
Authors: Fonseca De Freitas D. , Khondoker M. , Nazroo J. , Hayes R. , Bhui K. 
Published: September 2022

IntroductionStudies have shown ethnic inequalities in health, with a higher incidence of illnesses among people of some minoritised ethnic groups. Furthermore, it has been observed that people with severe mental illnesses have a higher risk for multimorbidity. However, no study has investigated ethnic disparities in comorbidity in people with a schizophrenia spectrum disorder.ObjectivesThis study investigates potential ethnic disparities in physical health comorbidity in a cohort of people with psychosis.MethodsUsing a cross-sectional design, we identified service-users of the South London and Maudsley NHS Trust who were diagnosed with a schizophrenia spectrum disorder between 2007 and 2020. We assessed the prevalence of asthma, bronchitis, diabetes, hypertension, low blood pressure, overweight or obesity, and rheumatoid arthritis. Latent class analyses were used to investigate distinct profiles of comorbidity. Multinomial regression was then used to investigate ethnic disparities in these profiles. The regression model was adjusted for gender, age, neighbourhood deprivation, smoking and duration of care.ResultsOn a sample of 23,418 service-users with psychosis, we identified two classes of comorbidity: low comorbidity and multiple comorbidities. Compared to the White British ethnicity, a higher risk for multiple comorbidities was observed for people with any Black background, Indian, Pakistani, Asian British, and mixed-race ethnicities. Furthermore, Black African women had a significantly higher risk for multiple comorbidities than their male counterparts.ConclusionsEthnic disparities are observed in multiple comorbidities among people with psychosis. Further research is needed to understand the impact of these disparities, especially in relation to mortality.DisclosureNo significant relationships.
Digital self-harm – Social Media and its impact on Non-Suicidal Self-Injury and suicidal behavior. A Longitudinal Mixed Method Study
Authors: Jensen M.E. , Vinberg M. , Andreasson K. , Klausen J. , Joergensen K. , Nordentoft M. 
Published: September 2022

IntroductionSeveral initiatives within psychiatric nursing targets Non-suicidal self-injury (NSSI) in DK, but none targets the new phenomenon Digital Self-harm. Digital self-harm involves the use of Social media (SoMe) to harm oneself for example by communicating condescending content about and to oneself through fake profiles, seeking out conflicts to be humiliated, and consciously get others to say vicious things about themselves. Further, images are exchanged showing wounds, broken extremities, etc. and thoughts and feelings are exchanged about suicidal actions as well as methods for both self-harm and suicide actions. We do not know enough about what constitutes the problem nor do we know how to address neither the behavior nor their consequences. Due to conflicting results, more research is needed to understand how media affects NSSI as well as suicidal behavior.ObjectivesThe overall objective of this study is to map, at a national level, how SoMe is used as part of NSSI and suicidal behavior and get insight as to what constitutes the behavior and how we address it through three sub-studies.MethodsThe study will be carried out as a mixed method study and includes a systematic review (Study 1), a qualitative part, which will be examined through interviews (Study 2), and finally a quantitative part that will be conducted through questionnaires (Study 3).ResultsThe project is ongoing.ConclusionsProspects of this study are that the project will create clarity about the essence of the phenomenon of digital self-harm, how NSSI and suicidal behavior is affected and generate enough knowledge to develop interventions aiming digital self-harming and suicidal behavior.DisclosureNo significant relationships.
Assessment of the performance of assertive community treatment: the case of Bizkaia (Spain)
Authors: Díaz-Milanés D. , Almeda N. , García-Alonso C. , Salvador-Carulla L. 
Published: September 2022

IntroductionA mental health (MH) assertive community treatment (ACT) is always designed expecting for a decrease in the pressure (visits and readmissions) in inpatient services and to increase care quality. An appropriate management of ACT provision can be crucial to develop a balanced community-based MH ecosystems.ObjectivesTo assess the impact of the ACT on the performance of the MH ecosystem of Bizkaia (Basque Country, Spain).MethodsThe ecosystem is structured by 19 MH areas, supported by 5 ACT teams. Here ACT provides high intensity mobile outpatient care to people suffering from severe mental disorders. The impact of these teams on the ecosystem performance was assessed by Monte-Carlo simulation, the Data Envelopment Analysis (DEA) and fuzzy inference. The input variables were the availability, number of psychiatrics, nurses and total of professionals of ACT services in each area. The outputs were: frequentation, incidence and prevalence of ACT services in each MH area. Performance indicators were: relative technical efficiency (RTE), statistical stability and entropy.ResultsThe global ecosystem performance was high (RTE on average=0.799 -input DEA orientation- and 0.825 -output orientation- up to 1, the maximum), the stability was medium-low (respectively 38,67% and 13.64% up to 100%, the maximum) and the entropy was medium-high (respectively 70,41% and 65.9% up to 100%, the maximum).ConclusionsResults highlighted a positive impact of ACT in Bizkaia. Nevertheless, stability and entropy levels showed the existence of a high structural variability in ACT services due to the necessity of adjusting them to the user’s specific needs.DisclosureNo significant relationships.
Alcohol use disorder as a risk factor for violent offending in a sample of female forensic-psychiatric inpatients
Authors: Franke I. , Streb J. , Dudeck M. , Mayer J. , Steiner I. , Wolf V. 
Published: September 2022

IntroductionFemale gender is associated with a lower risk for aggressive behaviour and violent offending. Well established risk factors for aggressive behaviour are alcohol and other substance use, but previous studies focused mainly on male offenders and the general population. However, for therapeutic and prognostic reasons it is important to understand pathways to female offending.ObjectivesTo examine a sample of female forensic-psychiatric inpatients regarding the association of alcohol (AUD) and other substance use disorders (SUD) with violent offending (homicide, assault, robbery).MethodsWe conducted a retrospective cohort study of 334 female patients discharged before 01.01.2019 from a secure psychiatric hospital in Germany.ResultsIn total, 72% of the patients with AUD committed a violent crime, leading to admission to secure psychiatric treatment. In comparison a statistically significant lower rate (19%) of the SUD group was convicted of violent offending. Over 70% of the participants with AUD had a family history of AUD, and over 83% experienced physical violence in adulthood. We found no group differences (AUD vs. SUD) regarding aggressive behaviour during inpatient treatment.ConclusionsAccording to our results, AUD compared to other SUD, is a significant risk factor for violent offending in women. A family background with AUD and a history of physical abuse might function as a risk factor for both: developing an AUD and violent offending. The comparable rates of aggression in both groups during inpatient treatment suggest that abstinence is a protective factor.DisclosureNo significant relationships.