bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOXICIDADES SISTÊMICAS SIMULT NEAS RELACIONADAS À QUIMIOTERAPIA DO C NCER DE MAMA: UM RELATO OBSERVACIONAL E PROSPECTIVO
Authors: Marinho Pabliane Matias Lordelo , Barbosa-Lima Ricardo , Santos José Cleyton de Oliveira , Santos Dayane Ketlyn da Cunha , Costa Jéssica dos Santos , Silva Glebson Moura , Kameo Simone Yuriko , Sawada Namie Okino 
Published: October 2022

Objetivo: avaliar quantitativamente um cluster de toxicidades sistêmicas relacionadas à quimioterapia em mulheres com câncer de mama ao longo do tratamento. Métodos: foi realizado um estudo observacional e prospectivo, de natureza quantitativa, envolvendo 140 mulheres com câncer de mama expostas à quimioterapia como modalidade de tratamento. A ocorrência de 14 toxicidades sistêmicas (baseadas no Common Terminology Criteria for Adverse Events, versão 4.03) foi avaliada nos prontuários médicos em dois segmentos: no ciclo intermediário e ao fim da quimioterapia. As frequências foram comparadas entre os dois segmentos do estudo, associando separadamente cada toxicidade e agrupando a quantidade de toxicidades simultâneas de cada paciente, considerando o nível de significância (p) de 5%. Resultados: observou-se que a maioria das toxicidades sistêmicas foram associadas entre os segmentos do estudo, bem como a maioria se manifestou com maior frequência ao final da quimioterapia. As toxicidades mais frequentes (considerando ambos os segmentos) foram vômito (90.7%), cefaleia (88.6%) e astenia (87.9%). As mais incomuns foram leucopenia (7.1%), neutropenia (13.6%) e parestesia (32.1%). Ao comparar a quantidade de toxicidades sistêmicas simultâneas entre os segmentos, observou-se um aumento significativo ao final da quimioterapia em relação ao ciclo intermediário (p <0.001). Conclusão: as mulheres com câncer de mama experimentaram uma quantidade maior de toxicidade sistêmicas simultâneas ao final da quimioterapia, bem como uma alta frequência de toxicidades sistêmicas ao longo do tratamento foi observada.
PENGGUNAAN GADGET TERHADAP PERKEMBANGAN PSIKOSOSIAL ANAK USIAPRASEKOLAH DI TK NEGERI PEMBINA LIMBOTO KABUPATEN GORONTALO
Authors: Firmawati Firmawati , Biahimo Nur Uyuun I. 
Published: October 2022

Gadget is an English term that means a small electronic device with various special functions. The psychosocial development of children at the preschool stage is the basis of a person's psychosocial condition as an adult. The objective of research was to determine The correlation of The Use of Gadgets on Psychosocial Development in Preschool Children at TK Negeri Pembina Limboto. Sampling technique used Total Sampling with samples are 100 respondents.the design used analytic descriptive with cross sectional study. Based on the result obtained nilai p value = 0,003 means small then α = 0,05 (Chi square test). Concluded there is correlation of the use of gadgets on psychosocial development in preschool children at TK Negeri Pembina Limboto, Limboto District. Based on the result above the researcher suggests that kindergartens be able to introduce traditional games and improve communication and interaction between teacher and student.
EFEKTIVITAS MODEL ELEVASI KEPALA ANTARA 30º DAN 45º TERHADAP PENINGKATAN SATURASI OKSIGEN PADA PASIEN STROKE ISKEMIK DI RSUD dr.MM. DUNDA KABUPATEN GORONTALO
Authors: Pakaya Abdul Wahab , Nurliah Nurliah 
Published: October 2022

Stroke is a cerebrovascular disease which occurs suddenly and causes neurological damage. This research was implemented to stroke patients at RSUD dr.MM.dunda, which aimed to find out the Effectiveness of head elevation models between 30° and 45° to increase oxygen saturation. The design used quasy experiment with non randominize pretest posttest contro group design approach. The samples were 22 respondents who are treated with head elevation between 30 ° and 45 ° for 4 weeks. Statistical test result obtained p value 0,000 less than alpha (p<0,05) means that Ho rejected, concluded that there is the influence of the elevation on increasing oxygen saturation and more influenced the 30° head elevation models to increase oxygen saturation in ischemic stroke patients at RSUD dr.MM.Dunda Limboto.
PERBANDINGAN KOMPRES HANGAT PADA DAERAH DINDING PERUT, VENA-VENA BESAR (AXILA) DAN DAERAH TEMPORAL TERHADAP PENURUNAN SUHU TUBUH KLIEN FEBRIS DI RSUD DR. M. M. DUNDA LIMBOTO
Authors: Syamsuddin Fadli , Pakaya Abdul Wahab 
Published: October 2022

Kompres hangat dapat dilakukan di daerah dinding perut, vena-vena besar (axilla) dan daerah temporal. Tujuan dari penelitian ini adalah untuk mengetahui perbandingan efektifitas pemberian kompres hangat pada daerah dinding perut, vena-vena besar (axila) dan daerah temporal terhadap penurunan suhu tubuh klien febris. Jenis penelitian ini adalah kuantitatif dengan rancangan There Group Pretest Posttest. Penelitian ini dilakukan di ruangan irina F dan irina H, di RSUD dr. M.M. Dunda Limboto. Tehnik pengambilan sampel pada penelitian ini adalah purposive sampling. Pada penelitian ini dilakukan pengujian yaitu penggunakan paired sample t test pada masing-masing kelompok intervensi yang dilanjutkan dengan analisis one way anova.Kesimpulan penelitian adalah terdapat perbedaan penurunan suhu tubuh antara kompres hangat pada daerah vena-vena besar (axila) dengan kompres pada daerah perut dan daerah temporal (ρvalue 0,000) dan tidak terdapat perbedaan kompres daerah perut dengan daerah temporal ditunjukkan (ρvalue 0,539).
Integrating Same-Level Peer-Assisted Learning in a Simulation-Based Emergency Dystocia Module for Final-Year Veterinary Students
Authors: Schlesinger Samira L. , Losansky Vera A. 
Published: October 2022

Due to faculty shortages, time restraints, and unpredictability of emergency cases, teaching emergency veterinary care is associated with a range of challenges. A novel simulation-based emergency veterinary care (EVC) module was introduced at the Department of Veterinary Medicine, Freie Universität Berlin. The module was mandatory for all final-year veterinary students ( n = 155) and consisted of a 5-hour online workshop series on communication skills, a series of interactive, virtual emergency cases, and a weeklong block event covering practical skills at different simulation-based learning stations. A same-level peer-assisted learning (PAL) approach was trialed at two learning stations. Sixteen students volunteered to act as student tutors for their peers. The student tutors received specific training and each tutored six groups of three to four tutees in one topic of their choice. Evaluation forms were filled out by both tutors and tutees with response rates of 100% and 89.7%, respectively. Most student tutors felt well prepared and comfortable in their role as tutor. They indicated exceptionally high levels of motivation and felt useful and competent during the exercise. The tutees reciprocated these opinions and specifically enjoyed the fun and positive learning environment that the tutors were able to create. Responses in the evaluation forms also indicated that the ratio of faculty member to tutors to tutees (1:3:9–12) was a good fit for the exercise. Reciprocal same-level PAL shows promise as an effective teaching tool for final-year veterinary students receiving EVC training. This translation was provided by the authors. To view the full translated article visit: https://doi.org/10.3138/jvme-2022-0038.de
Flexible endoscope–assisted suture release and barrel stave osteotomy for the correction of sagittal synostosis
Authors: Labuschagne Jason , Mutyaba Denis , Ouma John , Dewan Michael C. 
Published: October 2022

OBJECTIVE
Early suturectomy with a rigid endoscope followed by orthotic cranial helmet therapy is an accepted treatment option for single-suture craniosynostosis. To the authors’ knowledge, flexible endoscope–assisted suture release (FEASR) has not been previously described. Presented herein is their experience with FEASR for the treatment of isolated sagittal craniosynostosis.

METHODS
A retrospective analysis of the health records of patients who had undergone FEASR between March 2018 and December 2020 was performed. Patients under the age of 6 months who had been diagnosed with isolated sagittal synostosis were considered eligible for FEASR. Exclusion criteria included syndromic synostosis or multiple-suture synostosis. The cephalic index, the primary measure of the cosmetic endpoint, was calculated at prespecified intervals: immediately preoperatively and 6 weeks and 12 months postoperatively. Parental satisfaction with the cosmetic outcome was determined throughout the clinical follow-up and documented according to a structured questionnaire for the first 12 months.

RESULTS
A total of 18 consecutive patients met the criteria for study inclusion. The mean patient age at the time of surgery was 3.4 months (range 2–6 months). All patients underwent a wide craniectomy with no need to convert to an open procedure. The mean craniectomy width was 3.61 cm. Estimated blood loss ranged from 5 to 30 ml. The mean operative time was 75 minutes. No intraoperative complications were observed. The average length of stay was 2.6 days. The mean cephalic index was 67.7 preoperatively, 77.1 at 6 weeks postoperatively, and 76.3 at 1 year postoperatively. The mean percentage change in the cephalic index from preoperatively to the 12-month follow-up was 10.44 (p < 0.001). The mean follow-up was 17 months (range 12–28 months). All parents were satisfied with the cosmetic outcome of the procedure. No patients developed symptoms of raised intracranial pressure (ICP) or needed invasive ICP monitoring during the follow-up period. No patients required reoperation.

CONCLUSIONS
In this modest single-hospital series, the authors demonstrated the feasibility of FEASR in treating sagittal synostosis with favorable cosmetic outcomes. The morbidity profile and resource utilization of the procedure appear similar to those of procedures conducted via traditional rigid endoscopy.
Determining Appropriateness of Antibiotic Therapy in Nursing Home Residents: A Review
Authors: Mylotte Joseph 
Published: October 2022

Upwards of 70% of nursing home residents receive at least one course of antibiotics yearly but as many as 75% of these courses have been considered inappropriate. In response to this potential overprescribing of antibiotic nursing homes are now required to have an antimicrobial stewardship program to monitor and improve prescribing. However, determining appropriateness of antibiotic therapy in the nursing home setting has been a major challenge. The objectives of this review were to identify and review studies of appropriateness of antibiotic therapy in nursing homes with special focus on the criteria utilized for determining appropriateness. Of the 30 studies identified in the literature review, 50% utilized infection surveillance definitions that were not designed to assess appropriateness of antibiotic therapy in individual residents. There was also variation in the size of study populations, study design, and criteria for identifying the study population. These limitations not only make comparisons among studies problematic but also raise concerns about the validity of the findings regarding the level of appropriateness of antibiotic prescribing in nursing homes. Suggestions are provided for the design of future studies of antibiotic appropriateness in nursing homes that focus on standardizing the methodology to minimize the variation observed in the studies in this review.
ANALISIS DAMPAK PANDEMI COVID19 TERHADAP PERGERAKAN ORANG KE KAWASAN KOMERSIAL BERDASARKAN PENGGUNAAN LAHAN PARKIR (Studi Kasus Suzuya Mall Banda Aceh)
Authors: Fisaini Juliana , Isya Muhammad 
Published: October 2022

Tata guna lahan dipercaya mempengaruhi tarikan perjalanan. Hal ini dikarenakan tata guna lahan berhubungan erat dengan pemenuhan kebutuhan manusia. Pandemi Covid19 telah mempengaruhi berbagai aspek dalam kehidupan manusia, termasuk dalam melakukan pergerakan dalam memenuhi kebutuhan sehari-hari (aktivitas). Fenomena ini terjadi sangat signifikan di awal masa pandemi karena adanya pembatasan sosial oleh pemerintah. Penelitian ini bertujuan untuk menganalisis pergerakan orang ke kawasan komersial pada awal masa pandemi di Kota Banda Aceh, dengan merekam data penggunaan lahan parkir. Lokasi tinjauan adalah kawasan komersial pusat perbelanjaan Suzuya Mall Kota Banda Aceh. Data yang dikumpulkan terdiri dari data penggunaan lahan parkir sebelum dan selama awal pandemi, dimana diberlakukan himbauan pembatasan sosial di Kota Banda Aceh. Metode pengumpulan data dilakukan dengan mengambil data sekunder, yaitu data penggunaan lahan parkir yang bersumber dari mesin pencatat parkir otomatis. Analisis data dilakukan secara deskriptif berdasarkan data kendaraan yang masuk ke lahan parkir pada kawasan tinjauan. Data ini diolah dalam bentuk fluktuasi jumlah kendaraan per hari selama masa pengumpulan data. Analisis ini juga dapat mengidentifikasi efektivitas himbauan pemerintah terkait pembatasan sosial. Hasil menunjukkan bahwa terdapat penurunan pergerakan orang ke kawasan komersial dengan menggunakan sepeda motor sebesar 70,4%, dimana jumlah kedatangan tertinggi adalah 1936 kendaraan/hari menjadi 573 kendaraan. Sedangkan jumlah kunjungan dengan menggunakan mobil juga mengalami penurunan sebesar 57,53% dimana kunjungan tertinggi 1439 kendaraan/hari dan kunjungan terendah 611 kendaraan/hari. Namun demikian, telihat kenaikan jumlah kunjangan pada akhir pekan pertama pembatasan social. Dapat disimpulkan bahwa himbauan pembatasan sosial dari pemerintah mempengaruhi perilaku masyarakat dalam melakukan pergerakan di masa pandemi.
The PRIDIKSI DEBIT PUNCAK SUNGAI AIR KETAHUN HULU KABUPATEN LEBONG DENGAN MENGGUNAKAN METODE HIDROGRAF SATUAN SINTETIK GAMA I
Authors: Zega Haris Ifawan , Amri Khairul , Fauzi Muhammad 
Published: October 2022

INTISARI
Daerah aliran sungai (DAS) Air Ketahun Hulu merupakan salah satu DAS yang berada di Lebong. DAS Air Ketahun Hulu mengalir dari daerah hulu yang terletak diwilayah Kabupaten Lebong. Tujuan penelitian ini adalah untuk mendapatkan debit puncak rencana terhadap Desa Talang Bunut dan sekitarnya akibat sering dilanda banjir saat debit air naik pada DAS Air Ketahun Hulu dalam menganalisis hidrologi dengan menggunakan HSS Gama 1. Curah hujan sangat berpengaruh pada besarnya debit air yang mengalir pada suatu sungai. Analisi hidrologi untuk mendapatkan debit puncak dengan cara ini menggunakan data curah hujan harian selama 10 tahun. Debit puncak yang didapat pada DAS Air Ketahun Hulu yang berada di desa talang Bunut kecamatan Uram Jaya Kabupaten Lebong untuk periode ulang 100 tahun dengan metode HSS Gama I yaitu 3030,45 m3/detik dengan waktu puncak sebesar 2 jam
Kata kunci : Curah Hujan, Hidrograf satuan sintetik, Debit puncak
Engineered biosynthesis of plant polyketides by type III polyketide synthases in microorganisms
Authors: Liu Chang , Li Sijin 
Published: October 2022

Plant specialized metabolites occupy unique therapeutic niches in human medicine. A large family of plant specialized metabolites, namely plant polyketides, exhibit diverse and remarkable pharmaceutical properties and thereby great biomanufacturing potential. A growing body of studies has focused on plant polyketide synthesis using plant type III polyketide synthases (PKSs), such as flavonoids, stilbenes, benzalacetones, curcuminoids, chromones, acridones, xanthones, and pyrones. Microbial expression of plant type III PKSs and related biosynthetic pathways in workhorse microorganisms, such as Saccharomyces cerevisiae, Escherichia coli, and Yarrowia lipolytica, have led to the complete biosynthesis of multiple plant polyketides, such as flavonoids and stilbenes, from simple carbohydrates using different metabolic engineering approaches. Additionally, advanced biosynthesis techniques led to the biosynthesis of novel and complex plant polyketides synthesized by diversified type III PKSs. This review will summarize efforts in the past 10 years in type III PKS-catalyzed natural product biosynthesis in microorganisms, especially the complete biosynthesis strategies and achievements.
Sex differences in metabolically healthy and metabolically unhealthy obesity among Chinese children and adolescents
Authors: Cai Shan , Dang Jiajia , Zhong Panliang , Ma Ning , Liu Yunfei , Shi Di , Zou Zhiyong , Dong Yanhui , Ma Jun , Song Yi 
Published: October 2022

ObjectivesTo analyze sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents aged 7-18 years in China.MethodsWe enrolled 15,114 children and adolescents aged 7-18 years into the final analysis. Obesity phenotypes were classified by body mass index (BMI) and metabolic status as metabolically healthy or unhealthy obesity. In addition, we collected four possible influencing factors on obesity phenotypes through questionnaires, including demographic, parental, early life, and lifestyle indicators. Multinomial logistic regression analysis in a generalized linear mixed model (GLMM) was selected to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for identifying risk factors and control the cluster effects of schools. More importantly, the interaction terms of sex and each indicator were established to demonstrate the sex differences.ResultsThe prevalence of metabolically healthy obesity (MHO), metabolically unhealthy obesity (MUO), metabolically healthy overweight and obesity (MHOO), and metabolically unhealthy overweight and obesity (MUOO) were 3.5%, 5.6%, 11.1%, and 13.0% respectively, with higher prevalence in boys (5.3% vs. 1.6%, 7.9% vs. 3.1%, 14.3% vs. 7.7%, 15.6% vs. 10.1%). In addition, younger ages, single children, parental smoking, parental history of diseases (overweight, hypertension, diabetes), caesarean, premature, and delayed delivery time, high birth weight, insufficient sleep time, and excessive screen time were considered as important risk factors of MHO and MUO among children and adolescents (p &lt; 0.05). More notably, boys were at higher risks of MUO when they were single children (boys: OR = 1.56, 95% CI: 1.24-1.96; girls: OR = 1.12, 95% CI: 0.82-1.54), while girls were more sensitive to MUO with parental smoking (girls: OR = 1.34, 95% CI: 1.02-1.76; boys: OR = 1.16, 95% CI: 0.97-1.39), premature delivery (girls: OR = 3.11, 95% CI: 1.59-6.07; boys: OR = 1.22, 95% CI: 0.67-2.22), high birth weight (girls: OR = 2.45, 95% CI: 1.63-3.69; boys: OR = 1.28, 95% CI: 0.96-1.70), and excessive screen time (girls: OR = 1.47, 95% CI: 1.06-2.04; boys: OR = 0.97, 95% CI: 0.79-1.20), with significant interaction term for sex difference (pinteraction &lt; 0.05).ConclusionsMHO and MUO are becoming prevalent among Chinese children and adolescents. Significant sex differences in the prevalence of obesity phenotypes as well as their environmental and genetic risk factors suggest it might be necessary to manage obesity phenotypes problems from a sex perspective.
Crop residual burning correlations with major air pollutants in mainland China
Authors: Wang Tianwei , Meng Ke , Fu Peihong , Huang Wei 
Published: October 2022

Many studies have established the correlation between crop residual burning (CRB) and air pollutants such as particulate matter (PM) pollutants. However, few studies have compared CRB’s correlations with all major air pollutants, including PM with aerodynamic diameters less than 10µm (PM10) and 2.5 µm (PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and carbon monoxide (CO), during open-field CRB seasons. This study monitored daily CRB spots from 2015 to 2016 in China, together with daily concentrations of PM2.5, PM10, CO, SO2, NO2, and 8 h average O3 provided by the China National Environmental Monitoring Center. Temporal changes in air pollutant concentration at the provincial level and spatial contributions of CRB to air pollution at the monitoring-site level were analyzed. The results indicated that the decrease in CRB from 2015 to 2016 probably led to a decrease in the mean air pollutant concentration and maxima; it also probably led to more outliers at the provincial level in the CRB seasons, especially in Heilongjiang, Jilin, and Liaoning. Spatial contributions suggest that the Heilongjiang, Jilin, and Liaoning provinces experienced a regional increase in the concentrations of almost all major air pollutants during the CRB seasons. In Heilongjiang, Jilin, and Liaoning, 67.88%, 72.12%, 80.00%, 77.58%, and 69.09% of the monitoring sites recorded higher concentrations of PM2.5, PM10, NO2, O3 , and CO, respectively, in the winter CRB season of 2015 compared to other periods. In contrast, in other provinces with fewer and more widely distributed CRB spots, only the monitoring sites close to or on CRB spots experienced increases.
Perinatal outcomes of pregestational hypertension according to blood pressure range at 11–14 week scan: Impact of the 2017 ACC/AHA guidelines
Authors: Sepúlveda-Martínez Alvaro , Conrads Tomas , Guiñez Rodolfo , Guiñez Javiera , Llancaqueo Marcelo , Parra-Cordero Mauro 
Published: October 2022

ObjectiveThe aim of this study was to evaluate the impact on perinatal outcomes related to placental insufficiency with the application of the new 2017 ACC/AHA guidelines to a group of chronic hypertensive pregnancies during their first-trimester assessment.Study designThis retrospective cohort study included pregnancies with preconceptional hypertension and known perinatal outcomes. In the first trimester, a combined screening for preterm preeclampsia (p-PE) was performed, including blood pressure (BP), mean uterine artery Doppler, and maternal characteristics. Patients were divided, according to the 2017 ACC/AHA consensus, into the following groups: elevated or less, Stage 1, and Stage 2. For adverse perinatal outcome assessment, univariate and multivariate regression analyses were performed, considering the “elevated or less” group as a reference. Odds ratios (OR) were compared with linear trend analysis. The main outcomes measured were preterm PE and FGR &lt; 3rd percentile.ResultsOf the 130 included patients, 59 (45.4%) were classified as elevated or less, 47 (36.2%) as Stage 1, and 24 (18.4%) as Stage 2. p-PE showed a significant increase according to BP range [7% (OR = 1.0), 19.6% (OR = 3.2), and 21.7% (OR = 3.7)]; trend p = 0.02, for elevated or less, Stage 1, and Stage 2, respectively. There was a non-significant increased trend of FGR &lt; 3rd percentile according to the BP stage. The best multivariate predictive model for p-PE included a previous PE background (OR = 15) and mean arterial pressure in mmHg (OR = 1.1).ConclusionThe use of the 2017 ACC/AHA consensus in pregnancies with chronic hypertension identifies an intermediate risk group for placental-mediated diseases.
Some sufficient conditions on hamilton graphs with toughness
Authors: Cai Gaixiang , Yu Tao , Xu Huan , Yu Guidong 
Published: October 2022

Let G be a graph, and the number of components of G is denoted by c(G). Let t be a positive real number. A connected graph G is t-tough if tc(G − S) ≤ |S| for every vertex cut S of V(G). The toughness of G is the largest value of t for which G is t-tough, denoted by τ(G). We call a graph G Hamiltonian if it has a cycle that contains all vertices of G. Chvátal and other scholars investigate the relationship between toughness conditions and the existence of cyclic structures. In this paper, we establish some sufficient conditions that a graph with toughness is Hamiltonian based on the number of edges, spectral radius, and signless Laplacian spectral radius of the graph.MR subject classifications: 05C50, 15A18.