bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bovine serum albumin-functionalized graphene-decorated strontium as a potent complex nanoparticle for bone tissue engineering
Authors: Akbari Hossein , Askari Esfandyar , Naghib Seyed Morteza , Salehi Zeinab 
Published: July 2022

AbstractGraphene and its family have a great potential in tissue engineering because of their super mechanical properties, electrical conductivity and antibacterial properties. Considering other properties of graphene such as high surface area and ready-to-use functionalization according to the high oxygen-containing groups in graphene oxide family, some needs could be addressed in bone tissue engineering. Herein, we synthesized and decorated strontium nanoparticles (SrNPs) during the reduction process of graphene oxide using green and novel method. Without using hydrazine or chemical linkers, strontium NPs were synthesized and decorated on the surface of rGO simultaneously using BSA. The results of the UV–Vis, FTIR and Raman spectroscopy demonstrated that BSA could successfully reduce graphene oxide and decorated SrNPs on the surface of rGO. FESEM and TEM exhibited that in situ synthesized SrNPs had 25–30 nm diameter. Interestingly, cell viability for MC3T3-E1 cells treated with SrNPs-rGO, were significantly higher than BSA-rGO and GO in constant concentration. Furthermore, we investigated the alkaline phosphatase activity (ALP) of these nanosheets that the results demonstrated Sr-BSA-rGO enhanced ALP activity more than GO and BSA-rGO. Remarkably, the relative expression of RUNX 2 and Col1 genes of MC3T3-E1 cells was boosted when treated with Sr-BSA-rGO nanosheets. This study revealed that using proteins and other biomolecules as green and facile agent for decoration of smart nanoparticles on the surface of nanosheets, would be promising and assist researcher to replace the harsh and toxic hydrazine like materials with bio-friendly method. These results demonstrated that Sr-BSA-rGO had the excellent capability for regenerating bone tissue and could be used as an osteogenesis booster in implants.
Long-term anti-tumor effects following both conventional radiotherapy and FLASH in fully immunocompetent animals with glioblastoma
Authors: Liljedahl Emma , Konradsson Elise , Gustafsson Emma , Jonsson Karolina Förnvik , Olofsson Jill K. , Ceberg Crister , Redebrandt Henrietta Nittby 
Published: July 2022

AbstractRadiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced. The efficacy of FLASH in relation to conventional radiotherapy (CONV-RT) has not been extensively explored in fully immunocompetent animals. Fully immunocompetent Fischer 344 rats were inoculated with NS1 glioblastoma cells subcutaneously or intracranially. Radiotherapy was delivered with FLASH or CONV-RT at 8 Gy × 2 (subcutaneous tumors) and 12.5 Gy × 2 (intracranial tumors). Cured animals were re-challenged in order to explore long-term anti-tumor immunity. Serum analytes and gene expression were explored. The majority of animals with subcutaneous tumors were cured when treated with FLASH or CONV-RT at 8 Gy × 2. Cured animals could reject tumor re-challenge. TIMP-1 in serum was reduced in animals treated with FLASH 8 Gy × 2 compared to control animals. Animals with intracranial tumors survived longer when treated with FLASH or CONV-RT at 12.5 Gy × 2, but cure was not reached. CONV-RT and FLASH were equally effective in fully immunocompetent animals with glioblastoma. Radiotherapy was highly efficient in the subcutaneous setting, leading to cure and long-term immunity in the majority of the animals.
Misrepresentation of group contributions undermines conditional cooperation in a human decision making experiment
Authors: van den Berg Pieter , Liu Siyuan , Wenseleers Tom , Zhang Jianlei 
Published: July 2022

AbstractCooperative behaviour can evolve through conditional strategies that direct cooperation towards interaction partners who have themselves been cooperative in the past. Such strategies are common in human cooperation, but they can be vulnerable to manipulation: individuals may try to exaggerate their past cooperation to elicit reciprocal contributions or improve their reputation for future gains. Little is known about the prevalence and the ramifications of misrepresentation in human cooperation, neither in general nor about its cultural facets (self-sacrifice for the group is valued differently across cultures). Here, we present a large-scale interactive decision making experiment (N = 870), performed in China and the USA, in which individuals had repeated cooperative interactions in groups. Our results show that (1) most individuals from both cultures overstate their contributions to the group if given the opportunity, (2) misrepresentation of cooperation is detrimental to cooperation in future interactions, and (3) the possibility to build up a personal reputation amplifies the effects of misrepresentation on cooperation in China, but not in the USA. Our results suggest that misrepresentation of cooperation is likely to be an important factor in (the evolution of) human social behaviour, with, depending on culture, diverging impacts on cooperation outcomes.
Identification of FAT3 as a new candidate gene for adolescent idiopathic scoliosis
Authors: Nada Dina , Julien Cédric , Papillon-Cavanagh Simon , Majewski Jacek , Elbakry Mohamed , Elremaly Wesam , Samuels Mark E. , Moreau Alain 
Published: July 2022

AbstractIn an effort to identify rare alleles associated with adolescent idiopathic scoliosis (AIS) whole-exome sequencing was performed on a discovery cohort of 73 unrelated patients and 70 age-and sex matched controls, all of French-Canadian ancestry. A collapsing gene burden test was performed to analyze rare protein-altering variants using case–control statistics. Since no single gene achieved statistical significance, targeted exon sequencing was performed for 24 genes with the smallestpvalues, in an independent replication cohort of unrelated severely affected females with AIS and sex-matched controls (N = 96 each). An excess of rare, potentially protein-altering variants was noted in one particular gene,FAT3, although it did not achieve statistical significance. Independently, we sequenced the exomes of all members of a rare multiplex family of three affected sisters and unaffected parents. All three sisters were compound heterozygous for two rare protein-altering variants inFAT3. The parents were single heterozygotes for each variant. The two variants in the family were also present in our discovery cohort. A second validation step was done, using another independent replication cohort of 258 unrelated AIS patients having reach their skeletal maturity and 143 healthy controls to genotype nineFAT3gene variants, including the two variants previously identified in the multiplex family: p.L517S (rs139595720) and p.L4544F (rs187159256). Interestingly, twoFAT3variants, rs139595720 (genotype A/G) and rs80293525 (genotype C/T), were enriched in severe scoliosis cases (4.5% and 2.7% respectively) compared to milder cases (1.4% and 0.7%) and healthy controls (1.6% and 0.8%). Our results implicateFAT3as a new candidate gene in the etiology of AIS.
SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis
Authors: Wang Minghua , Wu Yongqi , He Yunbiao , Liu Jing , Chen Yingxing , Huang Jieqiong , Qi Guolong , Li Ping 
Published: July 2022

AbstractEndometrial epithelial cells carry distinct cancer-associated alterations that may be more susceptible to endometriosis. Mouse models have shown that overexpression of SIRT1 associated with oncogene activation contributes to the pathogenesis of endometriosis, but the underlying reason remains elusive. Here, we used integrated systems biology analysis and found that enrichment of endometrial stromal fibroblasts in endometriosis and their cellular abundance correlated negatively with epithelial cells in clinical specimens. Furthermore, endometrial epithelial cells were characterized by significant overexpression of SIRT1, which is involved in triggering the EMT switch by escaping damage or oncogene-induced induced senescence in clinical specimens and in vitro human cell line models. This observation supports that genetic and epigenetic incident favors endometrial epithelia cells escape from senescence and fuel EMT process in endometriosis, what could be overcome by downregulation of SIRT1.
Temporal variation in climatic factors influences phenotypic diversity of Trochulus land snails
Authors: Proćków Małgorzata , Kuźnik-Kowalska Elżbieta , Żeromska Aleksandra , Mackiewicz Paweł 
Published: July 2022

AbstractOrganisms with limited dispersal capabilities should show phenotypic plasticity in situ to keep pace with environmental changes. Therefore, to study the influence of environmental variation on the phenotypic diversity, we chose land snails,Trochulus hispidusandT. sericeus, characterized by high population variability. We performed long-term field studies as well as laboratory and common garden experiments, which revealed that temporal environmental changes generate visible variation in shell size and shape of these snails. Many shell measurements ofT. hispidusvaried significantly with temperature and humidity in individual years. According to this, the first generation ofT. hispidus, bred in controlled laboratory conditions, became significantly different in higher spire and narrower umbilicus from its wild parents. Interestingly, offspring produced by this generation and transplanted to wild conditions returned to the ‘wild’ flat and wide-umbilicated shell shape. Moreover, initially different speciesT. hispidusandT. sericeustransferred into common environment conditions revealed rapid and convergent shell modifications within one generation. Such morphological flexibility and high genetic variation can be evolutionarily favored, when the environment is heterogeneous in time. The impact of climate change on the shell morphometry can lead to incorrect taxonomic classification or delimitation of artificial taxa in land snails. These findings have also important implications in the context of changing climate and environment.
Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure–volume curves
Authors: Shi Linzheng , Herrmann Jacob , Bou Jawde Samer , Bates Jason H. T. , Nia Hadi T. , Suki Béla 
Published: July 2022

AbstractThe relationship between pressure (P) and volume (V) in the human lung has been extensively studied. However, the combined effects of gravity and the mechanical properties of elastin and collagen on alveolar and lung P–V curves during breathing are not well understood. Here, we extended a previously established thick-walled spherical model of a single alveolus with wavy collagen fibers during positive pressure inflation. First, we updated the model for negative pressure-driven inflation that allowed incorporation of a gravity-induced pleural pressure gradient to predict how the static alveolar P–V relations vary spatially throughout an upright human lung. Second, by introducing dynamic surface tension and collagen viscoelasticity, we computed the hysteresis loop of the lung P–V curve. The model was tested by comparing its predicted regional ventilation to literature data, which offered insight into the effects of microgravity on ventilation. The model has also produced novel testable predictions for future experiments about the variation of mechanical stresses in the septal walls and the contribution of collagen and elastin fibers to the P–V curve and throughout the lung. The model may help us better understand how mechanical stresses arising from breathing and pleural pressure variations affect regional cellular mechanotransduction in the lung.
3D food printing improves color profile and structural properties of the derived novel whole-grain sourdough and malt biscuits
Authors: Kewuyemi Yusuf Olamide , Kesa Hema , Meijboom Reinout , Alimi Oyekunle Azeez , Adebo Oluwafemi Ayodeji 
Published: July 2022

AbstractPresentation of foods is essential to promote the acceptance of diversified and novel products. This study examined the color profile, browning index (BI), and structural properties of 3D-printed and traditional biscuits from whole-grain (WG) sourdough and germinated flours. The processed flours and composite/multigrain flours comprising cowpea sourdough (CS) and quinoa malt (QM) were used to prepare the snacks, and their structural characteristics were determined. Compared with the traditional biscuits, the 3D-printed biscuits showed considerable distinction in terms of consistent structural design and color intensities. The in-barrel shearing effect on dough biopolymers, automated printing of replicated dough strands in layers, and expansion during baking might have caused the biscuits’ structural differences. The composite biscuit formulations had a proportional share of CS and QM characteristics. The 80% CS and 20% QM printed biscuit had a low redness and BI, increased cell volume, average cell area, and total concavity. The 60% CS and 40% QM printed snack showed improved lightness and yellowness, increased average cell elongation, and less hardness. The 3D-printed composite biscuits may be recommended based on their unique structural characteristics. Such attributes can enhance the acceptability of printed foods and reinvent locally prepared meals as trendy, sustainable, and functional foods.
Experimental study on deformation characteristics and pore characteristics variation of granite residual soil
Authors: Yin Song , Huang Jia’ning , Li Xinming , Bai Linjie , Zhang Xianwei , Li Chunqing 
Published: July 2022

AbstractThis paper investigates the regularity of microstructural evolution of Shenzhen granite residual soil in an attempt to determine its macrostructural deformation characteristics. The pore distribution and microstructure characteristics of granite residual soil are examined experimentally under different consolidation stresses, coupled with mercury injection tests and scanning electron microscopy. It is found that a microstructure exists in the granite residual soil and that the structural characteristics of granite residual soil in Shenzhen. The calculated pre-consolidation stress and structural yield strength of the granite residual soil are similar, indicating a phenomenon that resembles over-consolidation in the granite residual soil. This is fundamentally different from the mechanism of conventional over-consolidation in soil. It is also found that the relationship between the increment of mercury in soil samples and the stress of the mercury under different consolidation stresses is mainly trimodal. The significance of the research presented in this paper lies in the development of a clear understanding of the influence of the microstructure characteristics of granite residual soil on its macrostructural deformation, thereby providing a theoretical basis for engineering applications involving granite residual soil and the analysis of foundation deformation.
Determining the effective factors in predicting diet adherence using an intelligent model
Authors: Mousavi Hediye , Karandish Majid , Jamshidnezhad Amir , Hadianfard Ali Mohammad 
Published: July 2022

AbstractAdhering to a healthy diet plays an essential role in preventing many nutrition-related diseases, such as obesity, diabetes, high blood pressure, and other cardiovascular diseases. This study aimed to predict adherence to the prescribed diets using a hybrid model of artificial neural networks (ANNs) and the genetic algorithm (GA). In this study, 26 factors affecting diet adherence were modeled using ANN and GA(ANGA). A dataset of 1528 patients, including 1116 females and 412 males, referred to a private clinic was applied. SPSS Ver.25 and MATLAB toolbox 2017 were employed to make the model and analyze the data. The results showed that the accuracy of the proposed ANN and ANGA models for predicting diet adherence was 93.22% and 93.51%, respectively. Also, the Pearson coefficient showed a significant relationship among the factors. The developed model showed the proper performance for predicting adherence to the diet. Moreover, the most effective factors were selected using GA. Some important factors that affect diet adherence include the duration of the marriage, the reason for referring to the clinic, weight, body mass index (BMI), weight satisfaction, lunch and dinner times, and sleep time. Therefore, applying the proposed model can help dietitians identify people who need more support to adhere to the diet.
A simple proteinuria-based risk score predicts contrast-associated acute kidney injury after percutaneous coronary intervention
Authors: Fujiwara Wakaya , Ishii Hideki , Sobue Yoshihiro , Shimizu Shinya , Ishiguro Tomoya , Yamada Ryo , Ueda Sayano , Nishimura Hideto , Niwa Yudai , Miyazaki Akane , Miyagi Wataru , Takahara Shuhei , Naruse Hiroyuki , Ishii Junichi , Kiyono Ken , Watanabe Eiichi , Izawa Hideo 
Published: July 2022

AbstractContrast-associated acute kidney injury (CA-AKI) is a complication of percutaneous coronary intervention (PCI). Because proteinuria is a sentinel marker of renal dysfunction, we assessed its role in predicting CA-AKI in patients undergoing PCI. A total of 1,254 patients undergoing PCI were randomly assigned to a derivation (n = 840) and validation (n = 414) dataset. We identified the independent predictors of CA-AKI where CA-AKI was defined by the new criteria issued in 2020, by a multivariate logistic regression in the derivation dataset. We created a risk score from the remaining predictors. The discrimination and calibration of the risk score in the validation dataset were assessed by the area under the receiver-operating characteristic curves (AUC) and Hosmer–Lemeshow test, respectively. A total of 64 (5.1%) patients developed CA-AKI. The 3 variables of the risk score were emergency procedures, serum creatinine, and proteinuria, which were assigned 1 point each based on the correlation coefficient. The risk score demonstrated a good discriminative power (AUC 0.789, 95% CI 0.766–0.912) and significant calibration. It was strongly associated with the onset of CA-AKI (Cochran-Armitage test, p < 0.0001). Our risk score that included proteinuria was simple to obtain and calculate, and may be useful in assessing the CA-AKI risk before PCI.
The high-pressure lithium–palladium and lithium–palladium–hydrogen systems
Authors: Frost Mungo , McBride Emma E. , Smith Jesse S. , Glenzer Siegfried H. 
Published: July 2022

AbstractThe lithium–palladium and lithium–palladium–hydrogen systems are investigated at high pressures at and above room temperature. Two novel lithium–palladium compounds are found below $${18.7}\,{\mathrm{GPa}}$$

18.7

GPa

. An ambient temperature phase is tentatively assigned as $$F{\bar{4}}3m\,\hbox {Li}_{17}\hbox {Pd}_{4}$$

F

4

¯

3
m

Li
17

Pd
4

, with $$a = 17.661(1)$$

a
=
17.661
(
1
)

Å at 8.64 GPa, isostructural with $$\hbox {Li}_{17}\hbox {Sn}_{4}$$

Li
17

Sn
4

. The other phase occurs at high-temperature and is $$I{\bar{4}}3m\, \hbox {Li}_{11}\hbox {Pd}_{2}$$

I

4

¯

3
m

Li
11

Pd
2

, $$a = 9.218(1)$$

a
=
9.218
(
1
)

Å at 3.88 GPa and 200 $$^\circ {\mathrm{C}}$$

∘

C

, similar to $$\hbox {Li}_{11}\hbox {Pt}_{2}$$

Li
11

Pt
2

, which is also known at high pressure. The presence of hydrogen in the system results in an $$I{\bar{4}}3m$$

I

4

¯

3
m

structure with $$a = 8.856(1)$$

a
=
8.856
(
1
)

Å at 9.74 GPa. This persists up to $${13.3}\,\mathrm{GPa}$$

13.3

GPa

, the highest pressure studied. Below $${2}\,{\mathrm{GPa}}$$

2

GPa

an fcc phase with a large unit cell, $$a = 19.324(1)$$

a
=
19.324
(
1
)

Å at 0.39 GPa, is also observed in the presence of hydrogen. On heating the hydrogen containing system at 4 GPa the $$I{\bar{4}}3m$$

I

4

¯

3
m

phases persists to the melting point of lithium. In both systems melting the lithium results in the loss of crystalline diffraction from palladium containing phases. This is attributed to dissolution of the palladium in the molten lithium, and on cooling the palladium remains dispersed.
Magnetocaloric performance of the three-component Ho1-xErxNi2 (x = 0.25, 0.5, 0.75) Laves phases as composite refrigerants
Authors: Ćwik Jacek , Koshkid’ko Yurii , Nenkov Konstantin , Tereshina-Chitrova Evgenia , Małecka Małgorzata , Weise Bruno , Kowalska Karolina 
Published: July 2022

AbstractTo date, significant efforts have been put into searching for materials with advanced magnetocaloric properties which show promise as refrigerants and permit realization of efficient cooling. The present study, by an example of Ho1−xErxNi2, develops the concept of magnetocaloric efficiency in the rare-earth Laves-phase compounds. Based on the magneto-thermodynamic properties, their potentiality as components of magnetocaloric composites is illustrated. The determined regularities in the behaviour of the heat capacity, magnetic entropy change, and adiabatic temperature change of the system substantiate reaching high magnetocaloric potentials in a desired temperature range. For the Ho1−xErxNi2 solid solutions, we simulate optimal molar ratios and construct the composites used in magnetic refrigerators performing an Ericsson cycle at low temperatures. The tailored magnetocaloric characteristics are designed and efficient procedures for their manufacturing are developed. Our calculations based on the real empirical data are very promising and open avenue to further experimental studies. Systems showing large magnetocaloric effect (MCE) at low temperatures are of importance due to their potential utilization in refrigeration for gas liquefaction.
Estimates of the genetic contribution to methane emission in dairy cows: a meta-analysis
Authors: Ghavi Hossein-Zadeh Navid 
Published: July 2022

AbstractThe present study aimed to perform a meta-analysis using the three-level model to integrate published estimates of genetic parameters for methane emission traits [methane yield (METY), methane intensity (METINT), and methane production (METP)] in dairy cows. Overall, 40 heritability estimates and 32 genetic correlations from 17 papers published between 2015 and 2021 were used in this study. The heritability estimates for METY, METINT, and METP were 0.244, 0.180, and 0.211, respectively. The genetic correlation estimates between METY and METINT with corrected milk yield for fat, protein, and or energy (CMY) were negative (− 0.433 and − 0.262, respectively). Also, genetic correlation estimates between METINT with milk fat and protein percentages were 0.254 and 0.334, respectively. Although the genetic correlation estimate of METP with daily milk yield was 0.172, its genetic correlation with CMY was 0.446. All genetic correlation estimates between METP with milk fat and protein yield or percentage ranged from 0.005 (between METP-milk protein yield) to 0.185 (between METP-milk protein percentage). The current meta-analysis confirmed the presence of additive genetic variation for methane emission traits in dairy cows that could be exploited in genetic selection plans.