bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATENÇÃO FARMACÊUTICA VOLTADA A IDENTIFICAÇÃO DA INTERAÇÃO FÁRMACO-NUTRIENTE E SUAS IMPLICAÇÕES.
Authors: Dos Santos Lucilene Pereira , Lima Marcio Amorim Tolentino , Haun Youssef Conrado , Da Silva Íris Terezinha Santos de Santana , De Santana Ana Carolina Moraes 
Published: November 2022

A assistência farmacêutica é o conjunto de ações e serviços que visa assegurar a assistência terapêutica integral, a promoção e a recuperação da saúde. Um dos desafios encontrados nesta prática profissional são os problemas relacionados aos medicamentos incluindo as interações fármaco-nutriente. o profissional farmacêutico, possui visão ampla e sistemática quanto aos riscos destas interações, logo, o acompanhamento é essencial na farmacoterapia. Sendo inúmeras as possibilidades de ocorrência de interações entre fármacos e nutriente, o objetivo deste trabalho foi identificar as principais interações relatadas na literatura e suas implicações, bem como evitá-las através da atenção farmacêutica. Para encontrar os resultados foi realizada uma revisão bibliográfica sistemática integrativa com as bases de dados SCIELO, BVMS e DOAJ. Os resultados evidenciaram diversas possibilidades de mecanismos de interações entre fármacos e alimentos com interferências nos processos farmacocinéticos que vão desde a absorção até a excreção, bem como nos processos farmacodinâmicos. Algumas interações produzem modificações na disponibilidade e na atividade do fármaco podendo acelerar o efeito desejável ou tornar indesejável. O emprego da atenção farmacêutica pode colaborar para prevenir, identificar e resolver as prováveis interações entre fármacos e nutrientes, aumentando desta forma a eficácia do medicamento e o resultado da terapia.
La “defensa” aristotélica de la esclavitud de los indios americanos: a propósito del dominium e imperium en la lectura de Juan Ginés de Sepúlveda
Authors: Valencia Constantino Genaro 
Published: November 2022

La defensa de la esclavitud de los indios americanos, que aparentemente Juan Ginés de Sepúlveda sostenía en el siglo XVI, es, como intentaré demostrar a lo largo de este trabajo, un malentendido resultante de interpretaciones poco atinadas y simplistas que no contemplan el tipo de lectura que hizo Sepúlveda de la Política de Aristóteles, la versión latina que publicó, el contexto político y social de la monarquía hispánica durante ese siglo y ciertos conceptos clave del derecho romano. Además, el prejuicio, que Menéndez Pelayo provocó, quizá sin intención, al traducir parte del título del tratado Democrates alter, sive de iustis belli causis apud Indos con “contra los indios”, creó un grave estigma desde el siglo XIX que ha condenado a Sepúlveda como defensor de la esclavitud. Con este texto, pretendo evidenciar la lectura e interpretación que él hizo del escrito aristotélico a la luz de algunos condicionantes textuales y contextuales que esclarecen la forma en que el humanista español abordó la cuestión filosófica y política de la conquista indígena.
Alimentos orgânicos
Authors: Garcia Alane Marília , Bleil Rozane Aparecida Toso , Weber Jucieli 
Published: November 2022

O presente estudo procurou conhecer a opinião dos consumidores de um município de pequeno porte da região sudoeste do Paraná em relação aos alimentos orgânicos, buscando identificar os fatores que possam interferir na sua aquisição e no consumo. Utilizou-se como instrumento para coleta de dados um questionário elaborado para este fim a partir de outros estudos já realizados e um questionário socioeconômico. A maioria dos participantes da pesquisa era adulta (86%; n=327), do gênero feminino (77%; n=294), residia na área urbana do município (80%; n=308) e o nível de escolaridade concentrou-se no ensino superior (42%; n=159). Quanto ao conhecimento sobre alimentos orgânicos, 96% (n=368) os entrevistados relataram que conhecem tais alimentos e o critério mais importante para sua aquisição é “fazer bem a saúde” (55%; n=211). Por outro lado, foi destacada a existência de poucos locais para adquirí-los (64%; n= 245), prevalecendo, assim, o baixo consumo pelo grupo (53%; n= 205). A maioria respondeu que confia nas universidades (76%; n= 291) e em profissionais nutricionistas (77%; n= 294) como referência sobre o tema e mais de um terço não confia nas mídias como agentes formadores de opinião (39%; n= 149). O principal fator que interfere na aquisição e no consumo de orgânicos é a falta de locais destinados à venda dos mesmos, o que restringe o acesso à população.
PERLAWANAN PEREMPUAN MENGHADAPI PELECEHAN VERBAL
Authors: Rahayu Sinta Dwi , Legowo Martinus 
Published: November 2022

<p><em>Gender inequality is a problem that can be found in countries that adhere to a patriarchal culture. Women become the cornered party in self-defense. The crime of verbal harassment is a threat faced by women. Verbal harassment is not a joke, but a real action that imprints and causes trauma to the victim. Verbal harassment can be said as a disguised crime that attacks the victim's psyche and is not realized by the community for the existence of the impact it causes. This study focuses on the efforts made by women in dealing with verbal abuse. This study uses a qualitative method with a phenomenological theory approach initiated by Hussrl. Data collection techniques used in-depth interviews and literature review to obtain rich and relevant data. Research Results Women are blamed by the community and perpetrators when they fight back during verbal harassment. Women were accused of the clothes they used, in addition, women were accused of not being able to respond to jokes in a relaxed manner. Verbal abuse that occurs in women leaves deep scars, causing a sense of trauma and distrust of others. </em><em></em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><strong><em>: Verbal Harassment, Resistance, Female</em></strong></p><p><strong><em> </em></strong></p><h2>Abstrak</h2><p>Ketimpangan gender menjadi permasalahan yang dapat dijumpai di negara penganut budaya patriarki. Perempuan menjadi pihak yang disudutkan dalam melakukan pembelaan diri. Kejahatan pelecehan verbal menjadi ancaman yang dihadapi perempempuan. Pelecehan verbal bukan merupakan bahan lelulocon, melainkan tindakan nyata yang membekas dan menimbukan traumatis pada korban. Pelecehan verbal dapat dikatakan sebagai kejahatan tersamar yang menyerang psikis korban dan tidak disadari oleh masyarakat atas eksistensi dampak yang ditimbulkan. Penelitian ini berfokus pada upaya yang dilakukan oleh perempuan dalam menghadapi pelecehan verbal. Penelitian ini menggunakan metode kualitatif dengan pendekatan teori fenomenologi yang digagas oleh Hussrl. Teknik pengumpulan data menggunakan wawancara mendalan dan kajian literatur untuk memperoleh data yang kaya dan relevan. Hasil Penelitian Pihak perempuan disalahkan masyarakat dan pelaku ketika melakukan perlawan saat pelecehan verbal. Perempuan dituduh atas pakaian yang mereka gunakan, selain itu perempuan mendapat tuduhan bahwa tidak mampu menanggapi bahan candaan dengan santai. Pelecehan verbal yang terjadi pada prempuan memberikan bekas luka yang mendalam, sehingga menimbulkan rasa traumatis dan ketidakpercayaan pada orang lain.</p><p> </p><p><strong>Kata </strong><strong>K</strong><strong>unci: Pelecehan verbal, Perlawanan, Perempuan</strong></p>
On a function maximization in the presence of fuzzy set of constraints with discrete fuzzy parameters
Authors: Mashchenko Serhii O. 
Published: November 2022

Abstract
The present paper investigates a fuzzy mathematical programming problem with a crisp objective function and a fuzzy set of indices of constraint functions with discrete fuzzy parameters. To formalize the set of feasible alternatives, the concept of intersection of fuzzy sets with a fuzzy set of operands is used. The result of this operation is a type-2 fuzzy set (T2FS). It is shown that the T2FS of feasible alternatives can be represented in the form of the collection of T2FSs with constant secondary grades. This approach allows us to define the notion of the weak solution T2FS. The concept of the solution T2FS (not weak) is also proposed. The primary domain of this T2FS is defined as the set of alternatives which together with the corresponding primary degrees of membership form the set of Pareto-optimal pairs to the four-criteria problem. In this problem, the degree of truth of the primary zero degree of membership (which characterizes the infeasibility of the alternative) is minimized in addition to the maximization of the objective function and the degrees (primary and secondary) of membership to the solution T2FS. The notion of a compromise maximizing alternative is given. Several results which enable us to simplify reasoning are obtained. Illustrative examples are given.
Node importance identification for uncertain networks
Authors: Yang Yulin , Li Wanping , Sheng Yuhong 
Published: November 2022

Abstract
This paper proposes the concepts of uncertain strength, uncertain degree, and uncertain clustering coefficient under uncertain networks, along with the proposes uncertain k -shell decomposition algorithm and uncertain h -index. Susceptible-Infected-Recovered (SIR) epidemic model is used to simulate the propagation process under uncertain networks. When compared to with the propagation process under uncertain k -shell decomposition algorithm and uncertain h -index, it is discovered that there are few differences among these methods. In order to find a better node importance identification algorithm, this paper combines these methods using the information entropy to form a new node importance identification method, which is called uncertain entropy method. SIR epidemic model is used to illustrate the difference among these methods.
Scalp acupuncture attenuates brain injury after intracerebral hemorrhage in rats by inhibiting necroptosis
Authors: yao jiayong , Dai Xiaohong , Yu Xueping , Teng Wei , Yu Weiwei , Kuang Binglin , Li Mingyue , Liu Xiaoying , Zheng Lei , Cao Hongtao , Zou Wei 
Published: November 2022

Abstract
Objectives The purpose of this study was to explore the effects and mechanisms of scalp acupuncture on necroptosis and inflammatory injury after intracerebral hemorrhage in rats.
Methods A total of 168 male Sprague–Dawley rats were divided into the sham operation group, intracerebral hemorrhage (ICH) group, scalp acupuncture group, and Nec-1 group. The Garcia score was used to evaluate neurological function. The occurrence of necroptosis after ICH was observed by propidium iodide staining, immunofluorescence co-localization, and transmission electron microscopy. The protein expression of RIP1, RIP3, and MLKL was detected by immunohistochemistry and Western blot analysis, and the levels of TNF-α and IL-1β were determined by enzyme-linked immunosorbent assay. Brain water content was measured by the dry wet weight method.
Results The results showed that scalp acupuncture could alleviate neurologic deficits, inhibit the occurrence of necroptosis, decrease the expression of RIP1, RIP3, and MLKL, reduce the release of TNF-α and IL-1β, and reduce brain edema. This effect was similar to the effect of the necroptosis-specific inhibitor Nec-1.
Conclusion Our study showed that scalp acupuncture may inhibit RIP1/RIP3/MLKL-mediated necroptosis in rats following ICH. In addition, the anti-inflammatory effect and the reduction of brain edema by acupuncture after ICH may be achieved partly through the inhibition of necroptosis.
Statistical Analysis of Modified Whale Optimization Algorithm for Active Power Loss Minimization
Authors: SAHAY SHUVAM , Upputuri Ramanaiah , Kumari Pooja , Kumar Niranjan 
Published: November 2022

Abstract
Optimal reactive power dispatch has an influential impact on improving the power quality of different utilities connected to the power system. It is a non-linear, non-convex, mixed-integer type problem formulated to minimize the active power loss considering generator voltage, tap setting value, and reactive power compensation as a control variable. In this article, a novel modified whale optimization algorithm is applied to solve this problem. A non-linear adaptive weight and an improved golden sign operator are being used to modify the basic whale algorithm. It improves the randomness due to parameter variation and enlarges the search area for accurate global solutions. It prevents the algorithm from local convergence. It also improves the convergence speed as compared to the basic whale optimization algorithm. It is tested and verified on the standard IEEE-57 bus system and IEEE-118 bus system. The solutions given by this method are compared with that of recently developed techniques for proving its dominance over the other techniques. The power losses of the IEEE-57 bus system are reduced to 1.78% and for the IEEE-118 bus system are reduced to 2.66%. Additionally, the comparative statistical analysis is performed in terms of the probability density function and cumulative density function along with the Wilcoxon rank test on the above test systems for 30 independent runs. The statistical analysis results prove that this algorithm is highly efficient in solving this problem compared to other techniques.
GEM-2: Next Generation Molecular Property Prediction Network by Modeling Full-range Many-body Interactions
Authors: Liu Lihang , He Donglong , Fang Xiaomin , Zhang Shanzhuo , Wang Fan , He Jingzhou , Wu Hua 
Published: November 2022

Abstract
Molecular property prediction is a fundamental task in the drug and material industries. Physically, the properties of a molecule are determined by its own electronic structure, which is a quantum many-body system and can be exactly described by the Schrödinger equation. Full-range many-body interactions between electrons have been proven effective in obtaining an accurate solution of the Schrödinger equation by classical computational chemistry methods, although modeling such interactions consumes an expensive computational cost. Meanwhile, deep learning methods have also demonstrated their competence in molecular property prediction tasks. Inspired by the classical computational chemistry methods, we design a novel method, namely GEM-2, which comprehensively considers full-range many-body interactions in molecules. Multiple tracks are utilized to model the full-range interactions between the many-bodies with different orders, and a novel axial attention mechanism is designed to approximate the full-range interaction modeling with much lower computational cost.
Multi-Affinity Network integration based on multi-omics data for tumor Stratification
Authors: Sun Zhensheng , Li Feng , Li Shengjun , Shang Junliang , Liu Jin-Xing , Liu Xikui , Li Yan 
Published: November 2022

Abstract
Tumor stratification facilitates clinical applications such as diagnosis and targeted treatment of patients. Sufficient multi-omics data have facilitated the study of tumor stratification, and many omics fusion methods have been proposed. However, most methods require that the omics data must contain the same samples. In this study, we propose a Multi-Affinity Network integration based on multi-omics data for tumor Stratification, call MANS. MANS addresses the limitation that omics data fusion must contain identical samples. Another novelty is that the subdivision of a single cancer type into a corresponding cancer subtype is unsupervised. Firstly, MANS constructs affinity networks based on the calculated similarity matrices between genes. Then we integrate multi-omics information by performing biased random walks in multiple affinity networks to obtain the neighborhood relationships of genes. Finally, the patient feature is constructed by using the somatic mutation profile. We classify the pan-cancer by lightGBM algorithm with an AUC value of approximately 0.94. The cancer is further subdivided into subtypes by unsupervised clustering algorithm. Among the 12 cancer types, MANS identifies significant differences in patient survival for subtypes of 10 cancer types. In conclusion, MANS is a potent precision oncology tool.
The Impact of Economic Growth, Globalization, and Land Transport Network on CO2 Emissions in Türkiye; Improved Empirical Results
Authors: Aytekin Ibrahim , Yetis Aysegul Demir , Yetis Recep 
Published: November 2022

AbstractThe aim of this study is to examine the effects of transportation activities, which are necessary for economic and commercial development, on greenhouse gas and carbon dioxide (CO2) emissions, and to evaluate changes in CO2emissions from road and rail transportation in Türkiye between 1977 and 2019 according to economic growth and globalization models. In this context, the data were analyzed using stationarity, time series analysis, unit root tests, boxplot, and statistical methods. As a result, it was seen that a very strong positive correlation exists between carbon emissions and economic growth, globalization, railway length, and highway length. The conclusion that all the variables are stationary at the first difference shows that the most suitable model in statistical terms is the Johansen cointegration test model. Accordingly, carbon emissions in Türkiye show that a long-running relationship exists between economic growth, globalization, railway length, and highway length variables. Box charts show that since the 1990s, economic growth, globalization, and increases in both road and railway lengths have directly and proportionally caused increases in carbon emissions. According to the results obtained, considering both environmental health and public health, there is a necessity reducin carbon emissions in order to ensure sustainable development.
Early oral feeding enhanced recovery after intestinal anastomosis in young infants aged less than 3 months -A real-word study
Authors: Lu Changgui , Sun Xinhe , Li Wei , Geng Qiming , Tang Weibing 
Published: November 2022

Abstract

BackgroundEarly oral feeding(EOF) has been proven with a low incidence of complications and fast recovery after surgery in some elective pediatric patients,however,evidence for initiating EOF after intestinal anastomosis(IA) in young infants aged less than 3 months,with immature immune system and organs, is insufficient.This tudy was primary designed to investigate the status and evaluate the feasibility of EOF in young infants with IA in mainland china.Methods491 young infants from 51 hospital in china mainland were divided into two groups(EOF group,n=88;traditional oral feeding,TOF group,n=403),and the clinical characteristics were collected and analyzed for evaluation of the status of EOF in young infants.The complications and recovery were also be compared to defined the feasibility after balancing the baseline by propensity score matching(PSM).ResultsThe time of TPN,PN and postoperative hospital stay were significantly shorter in the EOF group than that in the TOF group in young infants with IA(2.00[1.00,2.00]d vs. 5.00[3.00,6.00]d, p<0.001; 7.00[5.00,8.00]d vs.9.00[7.00,13.00]d, p<0.001;11.00[8.00,14.00]]d vs.14.00[11.00,17.00]d).There were significant differences in the spectrum of disorders, anastomotic sites,operative age and weight between EOF and TOF groups(p=0.002;p=0.029,p=0.045,p<0.001).The overall low rate of EOF in neonates and infants with IA was 17.9%,especially lower in intestinal atresia,stenosis,stoma closure,ileal-colonic,colonic anastomotic site,operative age less than 30 days and weight less than 2.5kg.The overall rate of and Clavien-Dindo II complications were higher in EOF than TOF group(p=0.002),however,no differences were found in severe complications(Clavien-Dindo III/ IV/V).ConclusionThe rate of EOF in young infants with IA is low in Mainland China and the spectrum of disorders,anastomotic sites,operative age and weight maybe factors affecting the performing of EOF. Nevertheless, implementing EOF in young infants with IA maybe beneficial, enhances the recovery, and does not increase the rate of severe complications. This study was registered on Clinical Trials. gov (NCT04464057)
Screening, diagnosis and evaluation of neonatal congenital heart disease in the southernmost region of China
Authors: Chen Qianqian , Zhang Dufei , Wang Yazhou , Zhang Xiangyun 
Published: November 2022

Abstract
Background and aim Early detection,diagnosis and treatment of children with congenital heart disease(CHD) has become a hot research issue.The aim of this study was to establish and promote an appropriate technology system for early screening-diagnosis-evaluation of neonatal CHD in the southernmost region of China--Hainan province.
Methods From January 1,2019 to December 31,2021,all screening staff from the screening institutions use 2 indicators,namely cardiac auscultation plus pulse oximetry(POX),to screen live newborns within 6 to 72 hours after birth.Diagnosis procedure for the screened-positive newborns was performed in the 31 certified medical institutions,and evaluation procedure for the newborns with confirmed CHD was performed in the 6 certified medical institutions.Data of screening,diagnosis,evaluation and treatment were filled in,uploaded and managed online through a neonatal CHD screening information management net.
Results A total of 321,447 live births participated in the CHD screening of this project,providing an overall screening rate of 97.59%(321,447/329,387).And 8,032 cases were screened to be positive.A total of 1099 cases of CHD were confirmed,providing a CHD prevalence of 3.419 per 1000 live births.Atrial septal defect was the most common CHD lesion.The prevalence of insignificant,significant,serious and critical CHD was 1.680,1.260,0.376 and 0.103 per 1000 live births,respectively.The sensitivity of cardiac auscultation,POX and 2 indicators combination(cardiac auscultation plus POX) for CHD detection was 69.15%,33.49% and 91.90%,respectively,and the specificity was 98.36%,99.43% and 97.81%,respectively.The ratio of both positive in 2 indicators in the children with major(serious and critical) CHD at the initial screening was significantly higher than that of single positive in any indicator (χ2=59.455,P<0.001).All children with CHD were evaluated,154 cases of children with major CHD were treated promptly.Only 15 cases of children with major CHD died,the standardized mortality of children aged 0-1 years with CHD was 4.67/100,000,and the case fatality rate of children with major CHD was 9.74%.
Conclusions Cardiac auscultation plus POX for CHD screening is non-invasive,simple,easy to operate and reliable,so that it is conducive to be promoted.It is of great significance to promote an appropriate technology for screening,diagnosis and evaluation of neonatal CHD,for which is conducive to timely diagnose and treat children with CHD,especially children with major CHD.