bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain
Authors: Chen Jiayang , Fuhler Nicole , Noguchi Kevin , Dougherty Joseph D. 
Published: October 2022

AbstractIn vitrostudies indicate the neurodevelopmental disorder gene Myelin Transcription Factor 1 Like (MYT1L) suppresses non-neuronal lineage genes during fibroblast-to-neuron direct differentiation. However, MYT1L’s molecular and cellular functions during differentiation in the mammalian brain have not been fully characterized. Here, we found that MYT1L loss leads to up-regulated deep layer (DL) but down-regulated upper layer (UL) neuron gene expression, corresponding to an increased ratio of DL/UL neurons in mouse cortex. To define potential mechanisms, we conducted Cleavage Under Targets & Release Using Nuclease (CUT&RUN) to map MYT1L binding targets in mouse developing cortex and adult prefrontal cortex (PFC), and to map epigenetic changes due to MYT1L mutation. We found MYT1L mainly binds to open chromatin, but with different transcription factor co-occupancies between promoters and enhancers. Likewise, multi-omic dataset integration revealed that, at promoters, MYT1L loss does not change chromatin accessibility but does increase H3K4me3 and H3K27ac, activating both a subset of earlier neuronal development genes as well asBcl11b, a key regulator for DL neuron development. Meanwhile, we discovered that MYT1L normally represses the activity of neurogenic enhancers associated with neuronal migration and neuronal projection development by closing chromatin structures and promoting removal of active histone marks. Further, we show MYT1L interacts with SIN3B and HDAC2in vivo, providing potential mechanisms underlying any repressive effects on histone acetylation and gene expression. Overall, our findings provide a comprehensive map of MYT1L bindingin vivoand mechanistic insights to how MYT1L facilitates neuronal maturation.
Type I PRMT inhibitor MS023 promotesSMN2exon 7 inclusion and synergizes with nusinersen to rescue the phenotype of SMA mice
Authors: Kordala Anna J , Ahlskog Nina , Hanifi Muhammad , Bhomra Amarjit , Stoodley Jessica , Lim Wooi Fang , Hammond Suzan M , Wood Matthew JA , Rinaldi Carlo 
Published: October 2022

AbstractSpinal muscular atrophy (SMA) is the leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients’ life expectancy and quality of life. Nevertheless, these are not without limitations, and research efforts are underway to develop new approaches to be used alone and in combination, to ensure improved and long-lasting benefits for SMA patients. Protein arginine methyltransferases (PRMT) are emerging as druggable epigenetic targets, with several small molecule PRMT inhibitors already in clinical trial stage. From a screen of highly potent and selective next generation epigenetic small molecules, we have identified MS023, a potent and selective type I PRMT inhibitor, able to promoteSMN2exon 7 inclusion and increase SMN protein levels in preclinical SMA model, by inhibiting the binding of splicing factor hnRNPA1 toSMN2pre-mRNA. Treatment of SMA mice with MS023 results in amelioration of the disease phenotype, with strong synergistic amplification of the positive effect when delivered in combination with theSMN2-targeting antisense oligonucleotide nusinersen. Moreover, transcriptomic analysis revealed that MS023 treatment has very minimal off-target effects and that the added benefit of the combination therapy is mainly attributable to targeting neuroinflammation. Our study warrants further clinical investigation of PRMT inhibition both as a stand-alone and add-on therapy for SMA patients.
Periodic boundaries in Molecular Dynamics simulations: why do we need salt?
Authors: Kopec Wojciech , Gapsys Vytautas 
Published: October 2022

AbstractMolecular dynamics (MD) simulations are usually performed by employing periodic boundary conditions (PBC). While this treatment of simulation system removes the necessity to treat the interactions with an otherwise artificial boundary, PBC also introduces additional constraints that need to be carefully considered for a robust and reliable simulation. Some of the issues pertaining to PBC are well explored and can be remedied by choosing a large enough unit cell, or by applying corrections to the generated trajectories. In current work, we study another artifact which cannot be alleviated by changing the box size. The artifact occurs due to the PBC imposed constraints affecting systems with permanent uncompensated dipoles, which is of particular relevance for lipid membrane simulations. Such dipoles often arise in many biologically-relevant setups, in particular those involving asymmetric lipid bilayers. The artifact manifests itself as an electric field formation in the simulation box which is counteracted by redistribution of mobile charge carriers (ions) and/or ordering of water dipoles. In the absence of ions, the artifact may cause strong water ordering, affecting thermodynamics of the studied system. This observation reveals a conceptually interesting effect of using explicit salt in MD simulations: ions help removing the unwanted periodicity-induced artifact occurring due to uncompensated electric dipoles. Therefore, we recommend adding mobile ions in molecular simulations whenever possible, and call for caution when simulating systems that require low salt concentration (or no salt at all), for example ion channel inactivation promoting conditions. In general, our findings are relevant for molecular simulations of any systems that contain uncompensated dipoles, that might occur more often than previously thought.
OPUS: an easy way to push the limits of SANS instruments towards USANS
Authors: Galvan Josa Victor Martín , Farhi Emmanuel , Schweins Ralf , Jackson Andrew , Mondelli Claudia 
Published: October 2022

Chemistry and physics have made major advances in recent years, yielding much more complex systems with high hierarchical order across multiple length scales. Accordingly, characterization tools are required that can elucidate the structure of such new materials over all length scales. Simultaneous small-angle neutron scattering (SANS) and ultra-small-angle neutron scattering (USANS) measurements are a unique tool to study such complexity and can be applied to very different fields of science. The OPUS (Option USANS) project is the study of a USANS option for SANS instruments, designed to be very versatile and easy to implement. The main idea is to provide the opportunity to study at the same time, and under the same experimental conditions, complex systems such as polymers, bio-systems, complex fibres and self-assembling systems. More specifically, this work presents the design of an option that could be applied to the suite of SANS instruments at the European Spallation Source (ESS) which will allow exploration of a Q range with a minimum Q down to one order of magnitude lower than the value attainable with the standard SANS instrument at the ESS. The proposed setup, based on the SAMBA (small-angle multi-beam analysis) approach, is very easy and fast to implement on a conventional SANS instrument and constitutes a multi-beam approach involving two multi-slits and a set of lenses near the sample position. This contribution describes all the focusing elements necessary to attain the proposed configuration and a detailed study using McStas simulations to optimize all the parameters involved for two SANS instruments: the future LoKI at the ESS and the present D11 at the Institut Laue–Langevin, the latter used as a benchmark for the model. Simulations performed without taking into account gravity effects show that the multi-beam approach allows extending the Q ranges to 9 × 10−5–7 × 10−4 Å−1 and 5 × 10−5–3 × 10−4 Å−1 for LoKI and D11, respectively.
Impact of income diversification on bank stability: a cross-country analysis
Authors: Adem Mohammed 
Published: October 2022

PurposeThe impact of diversification on bank stability and risk remains an ongoing topic of discussion with inconclusive results. Hence, this study investigated the implications of income diversification on bank stability within African markets.Design/methodology/approachThe study utilised longitudinal financial data on 45 countries from 2000 to 2017 and employed static and dynamic panel model estimation.FindingsThe results of the study suggest income diversification technique could improve financial stability throughout typical and crisis periods which validate portfolio management theory. The study also confirms the “too big to fail” hypothesis, extensive diversifying over an optimal range negatively impacts stability. Banks with a high level of liquidity, a higher operating efficiency and a larger deposit ratio become more resilient. Banking capital regulations found to be the appropriate monitoring instrument for lowering risks and maintaining stability. However, profitability was found to have a positive effect on bank risk-taking. The finding also suggests that political institutions have substantial, direct implications that are positively related to bank fragility. Macroeconomic factors such as gross domestic product (GDP) growth and inflation also influenced bank stability.Practical implicationsThis study has important implications for bankers, regulators and academicians concerned about the effect of diversification on a bank’s risk-taking or stability in developing economies.Originality/valueTo the best of the author’s knowledge, this is the first study on Africa to analyse the quadratic influence of income diversification and the effects of political institutions on the level of bank stability.
Mapping research output on library and information science research domain in South Africa: a bibliometric visualisation
Authors: Wani Javaid Ahmad , Ganaie Shabir Ahmad , Rehman Ikhlaq Ur 
Published: October 2022

Purpose
The purpose of this study is to examine the research output on “library and information science” (LIS) research domain in South Africa. It also highlights the top LIS research organisations, authors, journals, collaboration types and commonly used keywords. This research will aid in the identification of emerging concepts, trends and advances in this subject.

Design/methodology/approach
The Web of Science (WoS), an indexing and abstracting database, served as a tool for bibliographical data. By applying advanced search features, the authors curated data from 1989 to 2021 through the WoS subject category WC = (Information Science & Library Science), limiting the scope to the region, CU = (South Africa), which resulted in 1,034 articles. Moreover, the research focuses on science mapping using the R package for reliable analysis.

Findings
The findings reveal that the publications have considerably grown over time, indicating significant attention among researchers in LIS. The findings indicate the critical operator’s performance, existing thematic choices and subsequent research opportunities. The primary topical fields of study that emerged from the bibliometric analysis are impact, information, science, model, management, technology, knowledge and education. Pouris and Fourie are the most productive citations, h-index and g-index. The influential institute was The University of Pretoria.

Research limitations/implications
The use of the WoS database for data collecting limits this study. Because the WoS was the only citation and abstract database used in this study, bibliometric investigations using other citation and abstract databases like “Scopus”, “Google Scholar” and “Dimension” could be interesting. This study presented a bibliometric summary; nevertheless, a systematic and methodical examination of highly cited LIS research publications could throw more light on the subject.

Practical implications
This paper gives valuable information about recent scientific advancements in the LIS and emerging future academic subject prospects. Furthermore, this research work will serve as a reference for researchers in various areas to analyse the evolution of scholarly literature on a particular topic over time.

Originality/value
By identifying the standard channels of study in the LIS discipline, and the essential journals, publications, nations, institutions, authors, data sources and networks in this subject, this bibliometric mapping and visualisation provide new perspectives into academic performance. This paper also articulates future research directions in this realm of knowledge. This study is more rigorous and comprehensive in terms of the analytical procedures it uses.
How and when does leader humility promote followers’ proactive customer service performance?
Authors: Peng Yan , Tian Jian , Zhou Xing , Wu Lunwen 
Published: October 2022

Purpose
This study aims to examine how and when leader humility influences subordinates’ proactive customer service performance (PCSP). Drawing upon the conservation of resources theory, this study theorizes a moderated mediation model with relational energy as the mediator and person–supervisor fit (P-S fit) as the moderator.

Design/methodology/approach
This study conducted a three-wave survey in 20 hotels in China, collecting 467 valid questionnaires from frontline employees and supervisors. Hierarchical regression analysis and the PROCESS procedure were adopted for data analyses.

Findings
Leader humility can facilitate followers’ PCSP, and relational energy mediates this relationship. Furthermore, P-S fit amplifies leader humility’s direct influence on relational energy, as well as magnifies leader humility’s indirect effect on PCSP through relational energy.

Research limitations/implications
Companies need to be more concerned about selecting qualified candidates for management positions and fostering their humility via training, focus on employees’ relational energy and P-S fit and attempt to encourage PCSP in multiple ways.

Originality/value
Research on PCSP has largely neglected the influence of leader humility, which has the potential to be particularly effective in today’s hospitality industry, characterized by high dynamics. This study extends the literature on PCSP by connecting it with leader humility. It also provides new insights into the mechanism and boundary condition from a relational and resource perspective.
Investigating the impact of COVID-19 on sustainable food supply chains
Authors: Kumar Vikas , Yetkin Ekren Banu , Wang Jiayan , Shah Bhavin , Frederico Guilherme Francisco 
Published: October 2022

PurposeThe ongoing pandemic has gravely affected different facets of society and economic trades worldwide. During the outbreak, most manufacturing and service sectors were closed across the globe except for essential commodities such as food and medicines. Consequently, recent literature has focused on studying supply chain resilience and sustainability in different pandemic contexts. This study aims to add to the existing literature by exploring the economic, environmental and societal aspects affecting the food supply chain and assessing the impact of COVID-19 on food sustainability.Design/methodology/approachA survey method has been adopted with a questionnaire instrument investigating the role of technology, government policies, geopolitics and intermediaries on sustainable organisational management. A five-point Likert scale (i.e. 1 = strongly disagree; 5 = strongly agree) is used to evaluate the responses. The findings are based on 131 responses from entry-level workers and senior executives of different food supply chains across Asia and Europe. The data has been analysed to derive insights into the impacts of this pandemic.FindingsThe survey concludes with the significant impact of COVID-19 on the three pillars of sustainability, i.e. economic, social and environmental dimensions. The empirical analysis shows digitalisation and its applications help mitigate the negative effect of COVID-19 on sustainability. In addition, the supportive government policies and intermediatory interventions were helpful in improving sustainability at each level.Research limitations/implicationsThe findings have implications for businesses and policymakers. Companies can learn from the advantages of digitalisation to counter the challenges imposed by the pandemic or similar situations in the future in maintaining the sustainability of their supply chains. Managers can also learn the importance of effective organisational management in driving sustainability. Finally, policymakers can devise policies to support businesses in adopting sustainable practices in their supply chains.Originality/valueThis study adds to the limited literature exploring the impact of COVID-19 on food supply chain sustainability through the triple bottom line lens. To the best of the authors’ knowledge, this is also one of the first empirical studies to examine the effect of technology, government and organisational management practices on the sustainability of food supply chains.
The Covid Shift: working women's punctuated equilibrium
Authors: Purcell Jennifer W. , Rodriguez Darlene Xiomara , Ring Kelsey A. 
Published: October 2022

PurposeThe purpose of this paper is to present a conceptual framework for examining the impact of the COVID-19 pandemic on working women.Design/methodology/approachThis conceptual paper on women in the formal workforce is grounded within the leadership and organization development literature.FindingsThe authors posit the COVID-19 pandemic and the subsequent instability in the US workforce, particularly among women and mothers, is effectively examined through the lens of punctuated equilibrium. Specifically, the widespread disruption initiated by the pandemic provides an opportunity for transformative change within organizations and society. Furthermore, working women impacted during this punctuated equilibrium are likewise positioned for transformation. The authors suggest the pandemic and its impact on the formal workforce can be leveraged for individual and organizational development as well as transformation, resulting in advancement toward self-authorship and increased equity within organizations, respectively.Originality/valueThis paper offers a novel integration and application of three leadership and organization development concepts: punctuated equilibrium, the self-authorship theory and Theory U, to better understand the impact of the COVID-19 pandemic on working women.
Institutions Ignored: A History of Select Committee Scrutiny in the House of Lords, 1968–2021
Authors: Connolly John , Flinders Matthew , Judge David , Torrance Michael , Tudor Philippa 
Published: October 2022

AbstractWithin the vast seam of scholarship on parliamentary history the evolution and role of select committees in the house of lords, particularly in relation to investigatory or policy‐focused committees, has been almost completely overlooked. They have been ‘institutions ignored’. This gap in the existing research base is particularly stark when compared with the very large literature on the history of select committees in the house of commons. This article fills this gap by providing the first detailed historical account of the evolution of investigatory or policy‐focused committees in the house of lords. This account reveals the evolution of a distinctive ‘scrutiny style’ moulded around the notion of complementarity, a highly specialised approach and an understanding of the merits of self‐restraint. However, during 2018–21 a fundamental review of the investigatory committee system was undertaken within the house of lords which led to significant change in relation to both the structure and ambition of committees. The impact of this reform agenda is likely to ensure that select committees in the Lords are far more visible in the future, within and beyond the Palace of Westminster, than they were in the past.
River Basin Export Reduction Optimization Support Tool; a tool to screen options for reducing nutrient loads while minimizing cost
Authors: Chamberlin Catherine , ten Brink Marilyn , Munson Kate , Le Alyssa , Detenbeck Naomi 
Published: October 2022

AbstractExcess loading of nitrogen and phosphorus to river networks causes environmental harm, but reducing loads from large river basins is difficult and expensive. We developed a new tool, the River Basin Export Reduction Optimization Support Tool (RBEROST) to identify the least‐cost combinations of management practices that will reduce nutrient loading to target levels in downstream and mid‐network waterbodies. We demonstrate the utility of the tool in a case study in the Upper Connecticut River Basin in New England, USA. The total project cost of optimized lowest‐cost plans ranged from $18.0 million to $41.0 million per year over 15 years depending on user specifications. Plans include both point source and non‐point source management practices, and most costs are associated with urban stormwater practices. Adding a 2% margin of safety to loading targets improved the estimated probability of success from 37.5% to 99%. The large spatial scale of RBEROST, and the consideration of both point and non‐point source contributions of nutrients, make it well suited as an initial screening tool in watershed planning.
Voice activity detection in eco‐acoustic data enables privacy protection and is a proxy for human disturbance
Authors: Cretois Benjamin , Rosten Carolyn M. , Sethi Sarab S. 
Published: October 2022

Abstract

Eco‐acoustic monitoring is increasingly being used to map biodiversity across large scales, yet little thought is given to the privacy concerns and potential scientific value of inadvertently recorded human speech. Automated speech detection is possible using voice activity detection (VAD) models, but it is not clear how well these perform in diverse natural soundscapes. In this study we present the first evaluation of VAD models for anonymization of eco‐acoustic data and demonstrate how speech detection frequency can be used as one potential measure of human disturbance.

We first generated multiple synthetic datasets using different data preprocessing techniques to train and validate deep neural network models. We evaluated the performance of our custom models against existing state‐of‐the‐art VAD models using playback experiments with speech samples from a man, woman and child. Finally, we collected long‐term data from a Norwegian forest heavily used for hiking to evaluate the ability of the models to detect human speech and quantify a proxy for human disturbance in a real monitoring scenario.

In playback experiments, all models could detect human speech with high accuracy at distances where the speech was intelligible (up to 10 m). We showed that training models using location specific soundscapes in the data preprocessing step resulted in a slight improvement in model performance. Additionally, we found that the number of speech detections correlated with peak traffic hours (using bus timings) demonstrating how VAD can be used to derive a proxy for human disturbance with fine temporal resolution.

Anonymizing audio data effectively using VAD models will allow eco‐acoustic monitoring to continue to deliver invaluable ecological insight at scale, while minimizing the risk of data misuse. Furthermore, using speech detections as a proxy for human disturbance opens new opportunities for eco‐acoustic monitoring to shed light on nuanced human–wildlife interactions.