bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Performance of Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging in Differentiating Recurrence From Radiation Injury in Postoperative Glioma: A Meta-analysis
Authors: Zhang Hui-Mei , Huo Xiao-Bing , Wang Hua-Long , Wang Chen 
Published: August 2022

Purpose
It is important to differentiate between radiation injury (RI) and tumor recurrence (TR) in patients with glioma after surgery and radiotherapy. Our objective was to evaluate the use of dynamic susceptibility contrast-enhanced perfusion-weighted imaging to distinguish between TR and RI in patients with glioma.

Methods
Relevant studies published until October 2021 were identified in the PubMed, Embase, and Cochrane Library databases. Stata v12.0 and RevMan 5.3 were used for meta-analysis.

Results
In total, the meta-analysis incorporated 13 retrospective studies that included 513 patients with 522 lesions. Among the 522 lesions, 329 lesions were TRs and 193 lesions were RIs. The pooled relative cerebral blood volume value was significantly greater in the TR group (P < 0.00001) with significant heterogeneity (I
2 = 88%). The pooled sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 83% (95 confidence interval [CI], 77%–88%), 85% (95 CI, 77%–91%), 5.60 (95 CI, 3.61–8.70), and 0.20 (95% CI, 0.14–0.27), respectively. The heterogeneity of sensitivity (I
2 = 33.18%), specificity (I
2 = 24.01%), PLR (I
2 = 0.00%), and NLR (I
2 = 6.68%) is not significant. The area under the receiver operating characteristic curve was 0.91 (95% CI, 0.88–0.93). The 3.0 T magnetic resonance imaging, high-grade glioma, and Europe/America patient subgroups showed PLR greater than 5 and NLR less than 0.2. There was no significant indication of publication bias in the analysis (P = 0.496).

Conclusions
It is concluded that dynamic susceptibility contrast-enhanced perfusion-weighted imaging is effective for the diagnostic differentiation between TR and RI in patients with glioma.
A Retrospective Study Examining the Presentation and Management of Maxillofacial Soft Tissue Injuries Over 3 Years at a Regional Children’s Hospital and the Introduction of a Maxillofacial Laceration Grading Scale
Authors: Chundoo Shima , McMillan Kevin , Williams Rhodri 
Published: August 2022

Pediatric trauma has been affected by COVID-19, school closures, and stay at home advice. Health seeking behavior has decreased. The aim of this study is to assess trends in the presentation of maxillofacial soft tissue injuries and subsequent management within a regional pediatric hospital.
Retrospective study over a 3-year period (from 2019 to 2021 between the months of January and April). Inclusion of all pediatric patients seen by Oral and Maxillofacial Surgery team.
Between 2019 and 2021, the total number of patients dropped by over half. The average age dropped from 5.9 in 2019 to 3.8 in 2021. Males were more commonly seen. Falls are the most common cause of injuries across 2019 to 2021. Extraoral injuries increased by 21%. Intraoral injuries reduced by 8%. Lip lacerations accounted for most injuries. In 2020, there was 21% reduction in conservative management of injuries. Wound closure under local anesthetic peaked in 2020, by 12%. Wound closure under general anesthetic has increased by 5%, and accounts for nearly a third of all injuries in 2020 and 2021.
Patients are becoming younger and more likely to be male. Conservative management is most common but closure under local anesthetic and general anesthetic has increased. This may indicate an increase in the severity of soft tissue injuries or a trend toward operative management. We also introduce a laceration grading scale for clinician use to assist in assessing and documenting injury severity. Further research is needed to assess whether these trends continue or revert to prepandemic trends.
Diabetic Neuropathy Is Independently Associated With Worse Graft Outcomes and Incident Cardiovascular Disease After Pancreas Transplantation: A Retrospective Cohort Study in Type 1 Diabetes
Authors: Boswell Laura , Ventura-Aguiar Pedro , Alejaldre Aida , Navarro-Otano Judith , Cofan Frederic , Serés-Noriega Tonet , Pané Adriana , Montagud-Marrahi Enrique , Molina-Andújar Alicia , Ruiz Montserrat , Cucchiari David , Musquera Mireia , Ferrer-Fàbrega Joana , Diekmann Fritz , Esmatjes Enric , Amor Antonio J. 
Published: August 2022

Background.
Information about the impact of diabetic neuropathy (DN) on outcomes after pancreas transplantation (PT) is scarce. We assessed the independent relationship between DN markers with both graft survival and incident cardiovascular disease (CVD) after transplantation.

Methods.
A cohort study in individuals with type 1 diabetes and end-stage kidney disease who underwent PT between 1999 and 2015 was conducted. DN was assessed with vibration perception thresholds (VPTs) and orthostatic hypotension (pre-PT and 6 mo, 2–3, 5–6, and 8–10 y after transplantation). Pretransplantation and posttransplantation DN markers were related with graft failure/dysfunction and incident CVD during follow-up.

Results.
We included 187 participants (70% men, age 39.9 ± 7.1 y, diabetes duration 27.1 y), with a median follow-up of 11.3 y. Abnormal VPTs (≥25 V) were observed in 53%. After transplantation, VPTs improved (22.4 ± 8.4 pretransplant versus 16.1 ± 6.1 V at 8–10 y post-PT; P < 0.001); additionally, the prevalence of abnormal VPTs decreased (53% pretransplant versus 24.4% at 8–10 y; P < 0.001). After adjusting for age, sex, diabetes duration, blood pressure, body mass index, and previous CVD, pretransplant VPTs ≥25 V were independently associated with pancreas graft failure/dysfunction (hazard ratio [HR], 2.01 [1.01-4.00]) and incident CVD (HR, 2.57 [1.17-5.64]). Furthermore, persistent abnormal VPTs after 6 mo posttransplantation were associated with the worst outcomes (HR, 2.80 [1.25-6.23] and HR, 3.19 [1.14-8.96], for graft failure/dysfunction and incident CVD, respectively).

Conclusions.
In individuals with type 1 diabetes and end-stage kidney disease, PT was associated with an improvement of VPTs. This simple and widely available DN study was independently associated with pancreas graft function and CVD posttransplantation.
Visualization for epidemiological modelling: challenges, solutions, reflections and recommendations
Authors: Dykes Jason , Abdul-Rahman Alfie , Archambault Daniel , Bach Benjamin , Borgo Rita , Chen Min , Enright Jessica , Fang Hui , Firat Elif E. , Freeman Euan , Gönen Tuna , Harris Claire , Jianu Radu , John Nigel W. , Khan Saiful , Lahiff Andrew , Laramee Robert S. , Matthews Louise , Mohr Sibylle , Nguyen Phong H. , Rahat Alma A. M. , Reeve Richard , Ritsos Panagiotis D. , Roberts Jonathan C. , Slingsby Aidan , Swallow Ben , Torsney-Weir Thomas , Turkay Cagatay , Turner Robert , Vidal Franck P. , Wang Qiru , Wood Jo , Xu Kai 
Published: August 2022

We report on an ongoing collaboration between epidemiological modellers and visualization researchers by documenting and reflecting upon knowledge constructs—a series of ideas, approaches and methods taken from existing visualization research and practice—deployed and developed to support modelling of the COVID-19 pandemic. Structured independent commentary on these efforts is synthesized through iterative reflection to develop: evidence of the effectiveness and value of visualization in this context; open problems upon which the research communities may focus; guidance for future activity of this type and recommendations to safeguard the achievements and promote, advance, secure and prepare for future collaborations of this kind. In describing and comparing a series of related projects that were undertaken in unprecedented conditions, our hope is that this unique report, and its rich interactive supplementary materials, will guide the scientific community in embracing visualization in its observation, analysis and modelling of data as well as in disseminating findings. Equally we hope to encourage the visualization community to engage with impactful science in addressing its emerging data challenges. If we are successful, this showcase of activity may stimulate mutually beneficial engagement between communities with complementary expertise to address problems of significance in epidemiology and beyond. Seehttps://ramp-vis.github.io/RAMPVIS-PhilTransA-Supplement/.This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’.
Compositional modelling of immune response and virus transmission dynamics
Authors: Waites W. , Cavaliere M. , Danos V. , Datta R. , Eggo R. M. , Hallett T. B. , Manheim D. , Panovska-Griffiths J. , Russell T. W. , Zarnitsyna V. I. 
Published: August 2022

Transmission models for infectious diseases are typically formulated in terms of dynamics between individuals or groups with processes such as disease progression or recovery for each individual captured phenomenologically, without reference to underlying biological processes. Furthermore, the construction of these models is often monolithic: they do not allow one to readily modify the processes involved or include the new ones, or to combine models at different scales. We show how to construct a simple model of immune response to a respiratory virus and a model of transmission using an easily modifiable set of rules allowing further refining and merging the two models together. The immune response model reproduces the expected response curve of PCR testing for COVID-19 and implies a long-tailed distribution of infectiousness reflective of individual heterogeneity. This immune response model, when combined with a transmission model, reproduces the previously reported shift in the population distribution of viral loads along an epidemic trajectory.This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’.
Improved model quality assessment using sequence and structural information by enhanced deep neural networks
Authors: Liu Jun , Zhao Kailong , Zhang Guijun 
Published: August 2022

AbstractProtein model quality assessment plays an important role in protein structure prediction, protein design, and drug discovery. In this work, DeepUMQA2, a substantially improved version of DeepUMQA for protein model quality assessment, is proposed. First, sequence features containing protein co-evolution information and structural features reflecting family information are extracted to complement model-dependent features. Second, a novel backbone network based on triangular multiplication update and axial attention mechanism is designed to enhance information exchange between inter-residue pairs. On CASP13 and CASP14 datasets, the performance of DeepUMQA2 increases by 20.5% and 20.4% compared with DeepUMQA, respectively (measured by top 1 loss). Moreover, on the three-month CAMEO dataset (March 11 to June 04, 2022), DeepUMQA2 outperforms DeepUMQA by 15.5% (measured by local AUC0,0.2) and ranks first among all competing server methods in CAMEO blind test. Experimental results show that DeepUMQA2 outperforms state-of-the-art model quality assessment methods, such as ProQ3D-LDDT, ModFOLD8, DeepAccNet, Atom_ProteinQA, and QMEAN3.
Effect of the thickness of CAD‐CAM materials on the shear bond strength of light‐polymerized resin cement
Authors: Okutan Yener , Kandemir Banucicek , Donmez Mustafa Borga , Yucel Munir Tolga 
Published: August 2022

AbstractThis study aimed to investigate the effect of the thickness of computer aided design‐computer aided manufacturing (CAD‐CAM) restorative materials on the bond strength of light‐polymerized resin cement. Ninety specimens were prepared from three different CAD‐CAM materials (a leucite‐based glass‐ceramic [Empress CAD], a polymer‐infiltrated ceramic network [Vita Enamic], and a zirconia‐reinforced lithium silicate glass‐ceramic [Vita Suprinity]) in different thicknesses (1, 2, and 3 mm). One surface of each specimen was treated by using a single‐step self‐etching ceramic primer (Monobond Etch & Prime). Light‐polymerized resin cement was bonded to treated surfaces by exposure to a light‐emitting diode curing unit from the untreated side of the samples. Shear bond strength (SBS) between the ceramic and the resin cement was measured by using a universal testing machine. The leucite‐based glass‐ceramic had higher SBS values than the other materials at each thickness. For each material, 1 mm‐thick specimens had the highest SBS values. The difference between the SBS values of 2 mm‐ and 3 mm‐thick polymer‐infiltrated ceramic network was nonsignificant, whereas the SBS values of 2 mm‐thick leucite‐based glass‐ceramic and the zirconia‐reinforced lithium silicate glass‐ceramic were significantly higher than those of the corresponding 3 mm‐thick specimens. The choice of the material and its thickness may be highly important for clinical success when light‐polymerized resin cements are used for cementation.
“Keep a sinking boat afloat”: Class contradictions in a nascent shrimp farmers' cooperative in South China
Authors: Huang Yu 
Published: August 2022

AbstractWhether producer cooperatives could serve as a stepping stone leading to socialism is a much debated issue in Marxian scholarship. It has now been recognized that producer cooperatives might possess paradoxical potentials of promoting egalitarian economy and democratic management whilst at the same time constructing class hierarchies. So far, agrarian scholars have already identified how pre‐existing social differentiation facilitated privileged members to exploit the marginal non‐members. However, they have not explored how members exercise their agency in challenging the class division. In summer 2013, at the height of China's cooperatization movement, I embarked on a project of “engaged anthropology” to mobilize shrimp farmers in South China to establish a cooperative so as to challenge agribusinesses that squeeze farmers' returns, but members ended up hiring outside labour. However, members tried hard to bridge the hierarchy between investors and workers as well as between managers and labourers in order to expand its membership and build the village's reputation. This paper traces how cooperative members deal with the dilemmas between profit maximization and egalitarian distribution, highlighting the importance of class analysis for a pro‐poor cooperative movement.
KDM1A inhibition increases UVA toxicity and enhances photodynamic therapy efficacy
Authors: Mudambi Shaila , Fitzgerald Megan , Pera Paula , Washington Deschana , Chamberlain Sarah , Fidrus Eszter , Hegedűs Csaba , Remenyik Eva , Shafirstein Gal , Bellnier David , Paragh Gyorgy 
Published: August 2022

AbstractBackgroundLysine‐specific histone demethylase 1 (KDM1A/LSD1) regulates multiple cellular functions, including cellular proliferation, differentiation, and DNA repair. KDM1A is overexpressed in squamous cell carcinoma of the skin and inhibition of KDM1A can suppress cutaneous carcinogenesis. Despite the role of KDM1A in skin and DNA repair, the effect of KDM1A inhibition on cellular ultraviolet (UV) response has not been studied.MethodsThe ability of KDM1A inhibitor bizine to modify cell death after UVA and UVB exposure was tested in normal human keratinocytes and melanocytes, HaCaT, and FaDu cell lines. KDM1A was also downregulated using shRNA and inhibited by phenelzine in HaCaT and FaDu cells to confirm the role of KDM1A in UVA response. In addition, cellular reactive oxygen species (ROS) changes were assessed by a lipid‐soluble fluorescent indicator of lipid oxidation, and ROS‐related gene regulation using qPCR. During photodynamic therapy (PDT) studies HaCaT and FaDu cells were treated with aminolaevulinic acid (5‐ALA) or HPPH (2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a) sodium and irradiated with 0‐8 J/cm2 red LED light.ResultsKDM1A inhibition sensitized cells to UVA radiation‐induced cell death but not to UVB. KDM1A inhibition increased ROS generation as detected by increased lipid peroxidation and the upregulation of ROS‐responsive genes. The effectiveness of both ALA and HPPH PDT significantly improved in vitro in HaCaT and FaDu cells after KDM1A inhibition.ConclusionKDM1A is a regulator of cellular UV response and KDM1A inhibition can improve PDT efficacy.
Pilot study evaluating the tolerability of a 3 Gy × 10 daily fraction 3D‐conformal palliative radiation therapy protocol plus toceranib for the treatment of measurable carcinomas in the dog
Authors: Keyerleber Michele A. , Barber Lisa G. 
Published: August 2022

AbstractThe use of radiation therapy in conjunction with small molecule inhibitors is an appealing treatment combination for non‐resectable carcinomas, which tend to be locally invasive with variable risk of locoregional metastasis. This prospective, pilot study aimed to evaluate the tolerability and adverse event profile of concurrent toceranib and palliative‐intent radiation therapy (PRT) in dogs with measurable carcinoma and to secondarily evaluate short‐term measurable tumor response. Fifteen dogs with measurable carcinoma received toceranib and 3D‐conformal PRT in 3 Gy/fraction for 10 daily fractions. Adverse events were graded using standard schemes and tolerability was followed via quality‐of‐life questionnaires during the 12‐week treatment period. Thirteen dogs (87%) experienced acute radiation toxicity, graded as severe in three dogs. All dogs experienced toceranib toxicity, graded as severe in one dog. Seven dogs (47%) completed the 12‐week study protocol; four were withdrawn due to toxicity and/or associated poor quality of life and four developed progressive disease. Based on these preliminary results, this 3D‐conformal chemoradiation protocol should be considered with caution and only with proper owner education on potential toxicity. More conformal treatment planning techniques or alternative protocols should be investigated for improved tolerability.
Quel sens donner à la sécurisation culturelle pour la main-d’œuvre autochtone? Le contexte du secteur forestier québécois
Authors: Desrochers-Arsenault Jeanne , Beaudoin Jean-Michel , Dufour Marie-Ève 
Published: August 2022

Employment can enable First Nations to improve their socio-economic conditions and foster individual and collective well-being. At the same time, there is a growing scarcity of labour in the Canadian forestry sector. In order to address this issue, it is important to consider the difficulties in attracting and retaining First Nations workers in this sector, something that is also the purpose of the efforts undertaken by many First Nations in Quebec, as well as elsewhere in Canada. This qualitative case study research is in line with the initiatives of the Atikamekw of Wemotaci First Nation. Its objective is to better understand the issues and possible solutions to attract and retain Atikamekw workers in the forestry sector. The results show five sets of issues: ( i) the perception of a hierarchy, ( ii) inadequate training methods, ( iii) the individual nature of the work, ( iv) the inclusion of cultural practices, and ( v) the creation of community benefits. For forestry stakeholders interested in attracting and retaining First Nations employees, this research is an invitation to reflect on their practices. The results suggest various avenues to either implement or maintain a cultural safety approach with First Nations workers. [Journal translation]
Roles of Atmospheric Variability and Arctic Sea Ice in the Asymmetric Arctic–Eurasia Temperature Connection on Subseasonal Time Scale
Authors: Nie Yu , Ren Hong-Li , Zhang Yang , Zhang Pengfei 
Published: August 2022

Abstract
Despite the severe impacts on Eurasian extreme weather, the mechanisms and causes of the “warm Arctic–cold Eurasia” (WACE) pattern and its opposite phase “cold Arctic–warm Eurasia” (CAWE) remain a subject of active debate. With a focus on subseasonal time scale, this study investigates the roles of atmospheric variability and Arctic sea ice in the variation of asymmetric WACE and CAWE patterns in the cold season. WACE (CAWE) patterns are predominantly driven by the temperature advection by anticyclonic (cyclonic) wave activity anomaly over Ural region. Low-frequency processes from both eddy vorticity and heat fluxes are important for the formation of the Ural wave activity anomaly. The subseasonal Arctic sea ice anomaly plays an additional role in maintaining the persistence of WACE and CAWE anomalies through surface heat flux exchange and alteration of Ural wave activity anomaly. Both comprehensive and idealized numerical experiments suggest that sea ice anomalies or thermal forcing act to maintain the WACE pattern by increasing the persistence of Ural anticyclonic anomaly through reducing background flow. The net effect of subseasonal thermal forcing on the WACE and CAWE anomalies is dependent on the mean state on longer time scale. We argue that the dominance of WACE over CAWE is mainly attributed to stronger roles of internal low-frequency atmospheric variability in driving the Ural anticyclonic anomaly and sea ice anomaly or thermal forcing in extending the persistence of the Ural anticyclonic anomaly through modulation on the background flow.

Significance Statement
The purpose of this study is to better understand the subseasonal variability of the “warm Arctic–cold Eurasia” (WACE) and “cold Arctic–warm Eurasia” (CAWE) patterns, which have severe impacts on Eurasian extreme weather. We highlight a dominance of WACE over CAWE, and attribute it to stronger roles of atmospheric variability in driving the WACE pattern and Arctic sea ice in maintaining the WACE anomalies. These findings have important implications for improving the subseasonal prediction of regional extremes.
Association of hyperuricemia with apolipoprotein AI and atherogenic index of plasma in healthy Chinese people: a cross-sectional study
Authors: Duan Yan , Chang Xiaona , Ding Xiaoyu , An Yu , Wang Guang , Liu Jia 
Published: August 2022

Abstract
Background
The atherogenic index of plasma (AIP) is a predictor for cardiovascular diseases (CVD), while hyperuricemia is an independent risk factor for a variety of CVD. Apolipoprotein AI has been found to be a protective factor for CVD. However, the role of APO AI in the association between plasma uric acid and AIP among healthy Chinese people needs to be further explored.

Aims
To evaluate the relationship between blood uric acid and AIP level in healthy Chinese people. To evaluate the relationship between blood uric acid and Apolipoprotein AI in healthy Chinese people.

Method
A total of 3501 normal and healthy subjects who had physical examinations were divided into the hyperuricemia (HUA) group and the normouricemia (NUA) group.

Result
The AIP of HUA group was significantly higher than that of NUA group [0.17±0.30 vs. −0.08±0.29]. Apo AI (1.33 ± 0.21 vs. 1.47 ± 0.26 g/l) and HDL-c (1.12 ± 0.27 vs. 1.36 ± 0.33 mmol/l) were significantly lower in the HUA group than in the NUA group. LDL-C (2.81 ± 0.77 vs. 2.69 ± 0.73 mmol/l), Apo B (0.96 ± 0.20 vs. 0.89 ± 0.20 g/l), FBG (5.48 ± 0.48 vs. 5.36 ± 0.48 mmol/l) and HOMA-IR [2.75 (1.92–3.91) vs. 2.18 (1.50–3.12)] was significantly higher in HAU group than the NUA group. Increases in plasma UA were associated with increases in AIP (β = 0.307, p < 0.01) and decreases in Apo AI (β =  − 0.236, p < 0.01).

Conclusion
Hyperuricemia is an independent risk factor for high AIP level. Inhibition of Apolipoprotein AI may be one of the mechanisms of UA which is involved in the progression of cardiovascular disease.