bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric patients with acute lymphoblastic leukemia treated with blinatumomab in a real‐world setting: Results from the NEUF study
Authors: Locatelli Franco , Maschan Alexey , Boissel Nicolas , Strocchio Luisa , Alam Naufil , Pezzani Isabella , Brescianini Alessandra , Kreuzbauer Georg , Baruchel Andre 
Published: January 2022

AbstractBackgroundPrior to regulatory approval of blinatumomab in pediatric patients with relapsed/refractory Philadelphia chromosome‐negative B‐cell precursor acute lymphoblastic leukemia (R/R Ph− BCP‐ALL), blinatumomab was made available via an expanded access program (EAP).ProcedureThis retrospective observational study included patients receiving blinatumomab in the EAP between January 1, 2014 and June 30, 2017 who were followed until death, entry into a clinical trial, end of follow‐up, or end of the study period (December 31, 2017), whichever occurred first.ResultsAmong 113 children enrolled, 72 were diagnosed with R/R Ph− BCP‐ALL and 41 were minimal residual disease positive (MRD+, either Ph− or Ph+). In the R/R group, 38 (53%) patients achieved hematological response within two cycles. Of these, 19 (50%) proceeded to hematopoietic stem cell transplantation (HSCT) without bridging myelosuppressive therapy. Of 36 patients in the R/R group evaluable for MRD, 30 (83%) had an MRD response. In the R/R group, median relapse‐free survival was 5.4 months and median overall survival (OS) was 8.2 months. Of 36 patients in the MRD+ group who were evaluable for MRD after two cycles, 27 (75%) had an MRD response. Overall, 24 (59%) of the MRD+ patients proceeded to HSCT without other bridging therapy. Median disease‐free survival was 13.6 months; median OS was not reached.ConclusionsIn this real‐world pediatric cohort, blinatumomab was effective within two cycles. Over half of patients with R/R Ph− BCP‐ALL achieved hematological response and most achieved MRD response in the MRD+ group, confirming the efficacy of blinatumomab in pediatric trials.
Facile synthesis of tough metallosupramolecular hydrogels by using phosphates as temporary ligands of ferric ions to avoid inhibition of polymerization
Authors: Fang Lingtao , Hu Jian , Zhang Chuan Wei , Wei Jialun , Yu Hai Chao , Zheng Si Yu , Wu Zi Liang , Zheng Qiang 
Published: January 2022

AbstractForming carboxyl‐Fe3+ coordination bonds as physical crosslinks is an effective strategy to develop tough hydrogels. Considering the inhibition of ferric ions on free‐radical polymerization, these coordination bonds cannot be formed during the reaction, and a soaking process of preformed hydrogels is usually required for mechanical enhancement, resulting in uncontrollable gradient structure, long preparation time, and unnecessary waste of metallic ions. A facile strategy is reported here to prepare tough metallosupramolecular hydrogels by polymerization and in situ formation of coordination bonds with phosphates as the temporal ligands of Fe3+ ions. The phosphate ligands in the precursor solution form coordination complexes with the Fe3+ ions, which avoids the inhibition and ensures the polymerization. After swelling the resultant hydrogel in water, the ligands are substituted by carboxyl groups of the gel matrix due to the variation of local pH. The equilibrated hydrogel with carboxyl‐Fe3+ coordination bonds as the physical crosslinks possesses excellent mechanical properties that can be tuned over a wide range by adjusting the polymer compositions and the concentrations of phosphate ligands and Fe3+ ions. This strategy should be applicable to other systems to enable synthesis of functional hydrogels with Fe3+ ions as the additive toward specific applications in engineering and biomedical fields.
BowTie analysis of rooftop grid‐connected photovoltaic systems
Authors: Mohd Nizam Ong Nur Aliah Fatin , Mohd Tohir Mohd Zahirasri , Mutlak Mays Mahmood , Sadiq Muhammad Adnan , Omar Rozita , Md Said Mohamad Syazarudin 
Published: January 2022

AbstractWith the rapid growth of the worldwide photovoltaic (PV) installation, the number of fire incidents involving PV systems also shows an increasing trend. Several studies revealed that installing PV systems on the rooftop has introduced an additional fire risk to the building. Therefore, risk assessment is required to identify the possible cause of fire initiation involving PV systems and subsequently provide the solar industry with fire risk information regarding PV faults. A BowTie analysis of rooftop grid‐connected PV systems was conducted, where initiation of ignition was determined as the hazard and PV fires as the loss event. Four threats in the BowTie analysis were identified using fault tree analysis, that is, arc fault, ground fault, hotspot effect at PV modules, and overheating. Arc fault contributes the most to PV fire incidents, while poor installation of PV systems was found to be the primary underlying cause of all PV fault scenarios. The main factor is due to lack of fire safety knowledge and negligence behavior of the installers. The consequences of PV fires in the BowTie diagram were investigated from the event tree analysis. Twelve possible outcomes were identified and regrouped to five consequences, that is, respiratory poisons, electrical shock, fall from heights, asset damage, and fire propagation. The evaluation of the consequences of PV fire shows that electrical shock poses a very high risk to the surrounding people, including firefighters. Additional measures are proposed to reduce the impact of electric shock.
Global drivers of herbicide‐resistant weed richness in major cereal crops worldwide
Authors: Hulme Philip E 
Published: January 2022

AbstractBACKGROUNDThe number of herbicide‐resistant weeds differs across the globe but the reasons for this variation are poorly understood. Taking a macroecological approach, the role of six drivers of herbicide resistance in a country was examined for barley, maize, rice and wheat crops worldwide. Drivers captured agronomic measures (crop harvested area, herbicide and fertilizer input) as well as sources of sampling bias that result in under‐reporting of herbicide resistance (human population density, research intensity and time since the first record of resistance).RESULTSDepending on the crop, best subset regression models explained between 60% and 80% of the variation in herbicide‐resistant weeds recorded in countries worldwide. Global prevalence of herbicide‐resistant weeds is likely underestimated, especially in countries with limited capability in herbicide research. Numbers of resistant weeds worldwide will continue to increase. Agricultural intensification, captured by fertilizer and herbicide input, as well as further expansion of crop harvested area are primary drivers of future herbicide‐resistant weeds.CONCLUSIONBecause the evolution of herbicide resistance lags behind the selection pressures imposed by fertilizer and herbicide inputs, several countries (e.g. Brazil, South Africa, Uruguay) appear to exhibit a ‘herbicide resistance debt’ in which current agronomic conditions have set the scene for higher numbers of herbicide‐resistant weeds than currently observed. Future agricultural expansion will lead to more herbicide‐resistant weeds, especially in developing countries as their economies grow and where herbicide resistance is currently under‐reported. A global strategy for increasing national capability in herbicide resistance research is needed. © 2022 The Author. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Event‐based finite‐time H∞ filtering of discrete‐time singular jump network systems
Authors: Zhang Yingqi , Shi Peng , Basin Michael V. 
Published: January 2022

AbstractThis article presents the analysis and design problems of event‐based (EB) finite‐time (FT) filtering for discrete‐time singular Markov jump network systems (SMNSs) based on separation of matrix inequality variables. According to the EB method, an SMNS model of network‐induced delay is introduced. Sufficient conditions of singular stochastic FT boundedness are then obtained for the augmented SMNS model by applying a stochastic Lyapunov functional and introducing slack matrix variables. In addition, using separation schemes for decoupling matrix inequality variables, the EBFT filter gain matrices and triggered ones are co‐designed to ensure that the augmented SMNSs are singularly stochastic FT bounded with a prescribed performance index. Finally, a practical DC test example is presented to show effectiveness of the proposed approach.
The dilution effect in a freshwater mutualism: Impacts of introduced host species on native symbionts
Authors: Creed Robert P. , Bailey Gretchen L. , Skelton James , Brown Bryan L. 
Published: January 2022

AbstractThe dilution effect was originally proposed to describe the negative effect of increased host diversity on parasite or pathogen abundance; with greater host diversity, parasite or pathogen levels per host are predicted to be lower due to a higher probability of dispersing parasites or pathogens encountering noncompetent hosts. Dilution effects could occur in many mutualisms if dispersing symbionts encounter hosts that vary in their competence. Introduced, non‐native hosts can change the community competence of a local group of host species. Crayfish introductions are occurring world‐wide and these introductions are likely disrupting native crayfish‐symbiont systems. Branchiobdellidan symbionts declined on native Cambarus crayfish co‐occurring with non‐native Faxonius crayfish in the New River watershed, USA. We performed an experiment investigating the effect of host density (1 vs. 2 native hosts) and host diversity (1 native host and 1 introduced host) on branchiobdellidan abundance. The introduced Faxonius cristavarius is a noncompetent host for these worms. Six C. ingens were stocked on a Cambarus chasmodactylus in each treatment and worm numbers were followed over 34 days. Worm numbers decreased over time on C. chasmodactylus alone and in the treatment in which a C. chasmodactylus was paired with an F. cristavarius. Worm numbers remained highest in the 2 C. chasmodactylus treatment. There was no effect of host diversity on worm reproduction. Crayfish invasions may have negative effects on mutualistic symbionts depending on the competence of introduced hosts. Loss of native symbionts is one of the potential hidden, negative effects of invasions on native freshwater diversity.
Polyphosphate‐Grafted Fe3O4 Nanomagnets for the Removal of Trivalent Radionuclides from Acidic Nuclear Waste Solution
Authors: Pahan Sumit , Dutta Bijaideep , Panja Surajit , Barick Kanhu Charan , Banerjee Dayamay , Vincent Tessy , Sugilal Gopalakrishnan , Manohar Smitha , Prakash Kaushik Chetan 
Published: January 2022

AbstractThe removal of radionuclides from nuclear waste solution is one of the biggest environmental challenges in today's world. In this aspect, polyphosphate grafted Fe3O4 nanomagnets (PPNMs) were investigated for its efficiency in removal of trivalent radionuclides from acidic nuclear waste solution. Various characterization techniques like XRD, FTIR, TEM and DLS were used to characterize these PPNMs, which showed successful formation of single phase, polyphosphate functionalized aqueous stable Fe3O4 nanostructure with average size ∼10 nm. The kinetics of sorption for Am(III) and Eu(III) by the PPNMs was found to be very fast with equilibrium being attained within ∼5 min. The sorption of both the radionuclides was following pseudo second order kinetic model. With increasing pH of the solution, the sorption efficiency of PPNMs for both the radionuclides was found to increase, whereas it decreased with increasing ionic strength of the medium. These observations clearly suggested that the sorption process proceeds through electrostatic interaction between the nanomagnets and trivalent radionuclides. Moreover, the PPNMs retained their sorption efficiency for at least 10 successive cycles when desorbed with 0.2 M HNO3. Thus, these magnetic nanosorbents can be used as highly effective, separable and reusable materials for removal of trivalent radionuclides from acidic nuclear waste solution.
Recent Advances on Tuning the Interlayer Coupling and Properties in van der Waals Heterostructures
Authors: Wu Xin , Chen Xiyue , Yang Ruxue , Zhan Jianbin , Ren Yingzhi , Li Kun 
Published: January 2022

Abstract2D van der Waals (vdW) heterostructures are receiving increasing research attention due to the theoretically amazing properties and unprecedented application potential. However, the as‐synthesized heterostructures are generally underperforming due to the weak interlayer coupling, which inspires the researchers to find ways to modulate the interlayer coupling and properties, realizing the tailored performance for actual applications. There have been a lot of publications regarding the controllable regulation of the structures and properties of 2D vdW heterostructures in the past few years, while a review work summarizing the current advances is not yet available, though it is significant. This paper conducts a state‐of‐the‐art review regarding the current research progress of performance modulation of vdW heterostructures by different techniques. First, the general synthesis methods of vdW heterostructures are summarized. Then, different performance modulation techniques, that is, mechanical‐based, external fields‐assisted, and particle beam irradiation‐based methods, are discussed and compared in detail. Some of the newly proposed concepts are described. Thereafter, applications of vdW heterostructures with tailored properties are reviewed for the application prospects of the topic around this area. Moreover, the future research challenges and prospects are discussed, aiming at triggering more research interest and device applications around this topic.
Better Scrum through Essence
Authors: Jacobson Ivar , Sutherland Jeff , Kerr Brian , Buhnova Barbora 
Published: January 2022

AbstractWe live at an exciting time where software has become a dominant aspect of our everyday life. Although software provides opportunities for improving various aspects of our society, it also presents many challenges. One of them is development, deployment, and sustaining of high quality software on a broad scale. While agile methods (Scrum being one of the most prominent examples) ease the process, their popularity deteriorates the clarity and simplicity they were once meant to bring into software development. This article explores the synergy of Scrum and Essence, a domain model of software engineering processes, intending to become a common ground for software development methods, bringing clarity into the composition of methods from individual practices. This short communication motivates the interplay of Scrum and Essence, being accompanied with a set of videotutorials and 21 Scrum Essential cards to further guide more effective team's way of working.
In vitro antifungal activity of cold atmospheric microwave plasma and synergistic activity against Malassezia pachydermatis when combined with chlorhexidine gluconate
Authors: Lee Tae‐Hyun , Hyun Jae‐Eun , Kang Yeong‐Hun , Baek Seung‐Joon , Hwang Cheol‐Yong 
Published: January 2022

AbstractBackgroundThe antifungal efficacy of cold atmospheric microwave plasma (CAMP) against Malassezia pachydermatis has not been to be evaluated.ObjectiveTo examine the antifungal effects of CAMP against M. pachydermatis and its synergistic effects with chlorhexidine gluconate (CHX).MethodsA M. pachydermatis isolate was collected from a dog with otitis externa and Malassezia dermatitis at the Seoul National University Veterinary Medical Teaching Hospital. The antifungal effect was determined by applying CAMP to a M. pachydermatis isolate that was incubated for 3 days at 37°C. After 1, 2, 3 and 5 min of application, the efficacy of the plasma treatment was determined according to the number of colony forming units (CFUs). A mixture consisting of inoculum and CHX was applied to evaluate the synergistic effect of the plasma treatment in the same way.ResultsThe application of CAMP showed significant antifungal effects against M. pachydermatis. The antifungal effect of CAMP was enhanced by an increased exposure time and output power. The application of CAMP with 0.02% and 0.2% CHX resulted in lower survival rates against M. pachydermatis when compared with its sole application at 1 or 2 min.ConclusionsThe study findings demonstrate that CAMP has a potential as a new antifungal option for M. pachydermatis and has synergistic antifungal effects with CHX in vitro. Clinical applications for CAMP are necessary to assess the antifungal efficacy for patients.
A suspected intermediate syndrome and intussusception following propoxur toxicity in a dog
Authors: Menchetti Marika , Galli Greta , Bravaccini Beatrice , Zappa Giovanni , Rocchi Paola 
Published: January 2022

AbstractAn 8‐month‐old, mixed breed dog was referred because of vomiting, generalised muscle tremors and miosis. A few hours before the presentation, the owners saw the dog eating something during the daily walk. The dog was initially treated with fluids, atropine, dexmedetomidine, maropitant and midazolam. Complete blood exams showed a marked reduction of cholinesterase activity. Blood toxicology tests revealed the presence of propoxur. Twenty‐four hours after the presentation, the dog developed a small intestinal intussusception. After an initial improvement, the dog developed weakness and respiratory difficulties. The neurological examination showed obtundation, severe generalised muscle weakness of neck and limbs, reduced flexor reflexes in the four limbs and a short and shallow respiratory pattern, suggesting suspected intermediate syndrome. The dog's neurologic conditions progressively improved, and he was discharged 5 days after presentation with only mild impairment of the neck strength.
An opioid‐free anaesthesia (OFA) technique for dorsal laminectomy in a dog subsequent to severe bradycardia and hypothermia after previous subcutaneous methadone administration
Authors: Libera Natalia , McFadzean William 
Published: January 2022

AbstractA 6‐year‐old, male, crossbreed dog presented for investigation and treatment of neck and thoracic limb pain. Frequent and repeated subcutaneous methadone administration resulted in severe side effects, including bradycardia, hypothermia and profound sedation. Based on the dog's previously evasive behaviour, suspected cervical myelopathy and technical impracticality, the decision was made not to antagonise opioid effects. Supportive treatment was given until general anaesthesia for diagnostic imaging, and surgery was deemed appropriate. In veterinary medicine, opioids are considered the gold‐standard analgesics; therefore, perioperative analgesia can be challenging when previous opioid use in a patient caused side effects. This case report presents an opioid‐free anaesthetic technique for magnetic resonance imaging and dorsal laminectomy in a dog. As a part of a balanced and multimodal approach, ketamine, dexmedetomidine, paracetamol, gabapentin, lidocaine and bupivacaine were included in the anaesthetic protocol; with meloxicam discontinued before surgery due to repeated episodes of vomiting and regurgitation.
Severe thrombocytopenia due to subinvolution of placental sites in a Maltese terrier
Authors: Crosby Jilli , Plested Mark , Hardas Alexandros , Olivares Gerard 
Published: January 2022

AbstractA 2‐year‐6‐month‐old, primiparous, female, entire Maltese terrier presented 4 weeks after whelping with an acute history of lethargy and vulval haemorrhage. It was found to be anaemic and severely thrombocytopenic, which raised the concern about thrombocytopenia being the primary cause of the profuse haemorrhage. The dog received a packed red blood cell transfusion that resulted in the improvement of the anaemia. The platelet count normalised without a specific intervention. Abdominal ultrasound revealed changes consistent with subinvolution of placental sites. An ovariohysterectomy was performed and the dog recovered uneventfully. This case has shown unusually severe thrombocytopenia secondary to haemorrhage, which should be considered a differential diagnosis for severe thrombocytopenia in dogs.
Quantum de Sitter horizon entropy from quasicanonical bulk, edge, sphere and topological string partition functions
Authors: Anninos Dionysios , Denef Frederik , Law Y. T. Albert , Sun Zimo 
Published: January 2022

Abstract
Motivated by the prospect of constraining microscopic models, we calculate the exact one-loop corrected de Sitter entropy (the logarithm of the sphere partition function) for every effective field theory of quantum gravity, with particles in arbitrary spin representations. In doing so, we universally relate the sphere partition function to the quotient of a quasi-canonical bulk and a Euclidean edge partition function, given by integrals of characters encoding the bulk and edge spectrum of the observable universe. Expanding the bulk character splits the bulk (entanglement) entropy into quasinormal mode (quasiqubit) contributions. For 3D higher-spin gravity formulated as an sl(n) Chern-Simons theory, we obtain all-loop exact results. Further to this, we show that the theory has an exponentially large landscape of de Sitter vacua with quantum entropy given by the absolute value squared of a topological string partition function. For generic higher-spin gravity, the formalism succinctly relates dS, AdS± and conformal results. Holography is exhibited in quasi-exact bulk-edge cancelation.
The four-loop $$ \mathcal{N} $$ = 4 SYM Sudakov form factor
Authors: Lee Roman N. , von Manteuffel Andreas , Schabinger Robert M. , Smirnov Alexander V. , Smirnov Vladimir A. , Steinhauser Matthias 
Published: January 2022

Abstract
We present the Sudakov form factor in full color $$ \mathcal{N} $$
N
= 4 supersymmetric Yang- Mills theory to four loop order and provide uniformly transcendental results for the relevant master integrals through to weight eight.
The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function
Authors: Kulikauskas Molly R. , X Shaka , Bautch Victoria L. 
Published: January 2022

AbstractBlood vessels expand via sprouting angiogenesis, and this process involves numerous endothelial cell behaviors, such as collective migration, proliferation, cell–cell junction rearrangements, and anastomosis and lumen formation. Subsequently, blood vessels remodel to form a hierarchical network that circulates blood and delivers oxygen and nutrients to tissue. During this time, endothelial cells become quiescent and form a barrier between blood and tissues that regulates transport of liquids and solutes. Bone morphogenetic protein (BMP) signaling regulates both proangiogenic and homeostatic endothelial cell behaviors as blood vessels form and mature. Almost 30 years ago, human pedigrees linked BMP signaling to diseases associated with blood vessel hemorrhage and shunts, and recent work greatly expanded our knowledge of the players and the effects of vascular BMP signaling. Despite these gains, there remain paradoxes and questions, especially with respect to how and where the different and opposing BMP signaling outputs are regulated. This review examines endothelial cell BMP signaling in vitro and in vivo and discusses the paradox of BMP signals that both destabilize and stabilize endothelial cell behaviors.