bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative hemodynamics as predictors of right heart failure post-left ventricular assist device
Authors: Orozco-Hernandez Erik J. , Kurt DeLay T. , Hoopes Charles W. , Gongora Enrique , Pamboukian Salpy , Xie Rongbing , Davies James E. , Vardas Panos N. 
Published: August 2022

AbstractBackgroundMechanical circulatory support has garnered significant popularity as both a bridge to transplant as well as a destination therapy for patients with end-stage heart failure. Right heart failure (RHF) is a devastating complication after LVAD placement and is very unpredictable. Assisted circulation of the left ventricle (LV) with an LVAD device could unmask an underlying RHF. However, otherwise healthy right ventricles (RVs) can develop RHF after LVAD placement as well due to poor adaptation to new filling pressures and altered hemodynamics. It has been proposed that preoperative volumetric measurements in the pulmonary and systemic vasculature may serve as indicators for a risk of RHF after LVAD implantation. The aim of this study is to examine a potential relationship of preoperative hemodynamic values such as pulmonary artery pulsatility index (PAPi) and the ratio of central venous pressure to pulmonary wedge pressure (CVP/PWP) as preoperative predictors for RHF post LVAD placement.MethodsWe retrospectively reviewed patients undergoing initially planned isolated LVAD implantation with or without concomitant procedures in our institution from January 1, 2017 to June 12, 2020. Data were gathered from hemodynamic records, echocardiographic interpretations, and clinical notes. Patients who had RHF after LVAD implantation but without hemodynamic data available within 14 days from the operation were excluded. Univariable analysis was performed.ResultsOf the 114 patients who received planned isolated LVAD surgery, 70 (61.4%) experienced RHF within the first 7 days postoperatively. PAPi did not correlate significantly with RHF vs non-RHF among LVAD recipients (3.1 ± 2.1 vs. 3.8 ± 3.4P= 0.21). Pre-op CVP/PWP did not differ significantly between RHF and non-RHF patients (0.4 ± 0.2 vs. 0.5 ± 0.8P= 0.28). There was a nonsignificant correlation between elevated pre-op PWP and those with RHF vs those without,OR= 1.05 (95%CI: 1.00, 1.10). Pre-op systolic pulmonary artery pressure (SysPAP) was elevated in patients with post-LVAD RHF compared to those without (51.3 ± 12.3 vs. 47.2 ± 13.0,P= 0.09).ConclusionPreoperative hemodynamic variables such as PAPi or CVP/PWP did not show a significant correlation predicting RHF post LVAD implantation. Acute RHF post LVAD implantation remains a complex medical entity. Several studies have devised multivariable risk scores; however, their performance has been limited. Despite the widespread use of preoperative hemodynamics measurements as risk scores, our study suggests these scores are not as accurate as their use would suggest, particularly among especially morbid patient populations. More prospective studies are needed to accurately demonstrate how preoperative hemodynamics could predict and help prevent this catastrophic complication.
Self-reported Resistance Training Is Associated With Better HR-pQCT–derived Bone Microarchitecture in Vegan People
Authors: Wakolbinger-Habel Robert , Reinweber Matthias , König Jürgen , Pokan Rochus , König Daniel , Pietschmann Peter , Muschitz Christian 
Published: August 2022

Abstract

Context
A plant-based lifestyle is a global trend; lower bone mineral density and increased fracture risk in vegan people are reported.

Objective
The primary objective was to assess trabecular and cortical bone microarchitecture in vegans and omnivores. Secondary objectives were to evaluate relationships between bone microarchitecture, nutrition parameters, and physical activity.

Methods
This was an observational study at the Medical Department II, St. Vincent Hospital (tertiary referral center for gastrointestinal, metabolic, and bone diseases, and teaching hospital of the Medical University of Vienna), including 43 healthy nonobese female and male subjects on a plant-based diet for at least 5 years, and 45 healthy nonobese female and male subjects on an omnivore diet for at least 5 years. The main outcome measures were the parameters of trabecular and cortical bone microarchitecture (high-resolution peripheral quantitative computed tomography), serum markers of bone turnover, nutrient intake (nutrition protocol), and self-reported resistance training (physical activity questionnaires).

Results
In the vegan group, trabecular and cortical structure were altered compared with omnivores. Vegans not reporting resistance training had diminished bone microarchitecture compared with omnivores not reporting resistance training. In vegans and omnivores reporting resistance training, bone structure was similar. In both vegan subgroups (resistance training and not resistance training), a small number of correlations between nutrient intake and bone microarchitecture were observed without a conclusive pattern.

Conclusion
Bone microarchitecture in vegans differed from matched omnivores but could not be explained solely by nutrient uptake. These differences were attenuated between the subgroups reporting resistance training. In addition to a well-planned diet, progressive resistance training on a regular basis should be part of the vegan lifestyle.
“We wait to be true people, Christians”: An Idolatry Confession in Zapotec
Authors: Tavárez David 
Published: August 2022

Context
This article presents a translation and analysis of the only extant formal confession of human sacrifice written in an Indigenous language in the colonial Americas. An analysis of this document, written in Northern Zapotec by the town officials of Yalalag in 1704, provides numerous insights about how a community deployed traditional rhetoric to seek mercy from their civil magistrate, and to provide a justification for committing acts of idolatry and child sacrifice. Rather than aligning with the canonical middle ground (nepantla), often used as a yardstick, this confession eloquently and incisively places Northern Zapotec society in tentative terrain point in terms of their knowledge of Christianity, and depicts Christianization as a long-term process, which confessants boldly tied to latent forms of negotiation.
Collective Disorientation and Catastrophic Precarity in the Hypermodern Era
Authors: Means Alexander J. , Slater Graham B. 
Published: August 2022

Abstract
Who can imagine a future today? Any sense of progress, or belief in the future, appears as merely another exclusive privilege of the ultrarich. Time seems to be accelerating faster than catastrophic trajectories can be metabolized. Meanwhile, hypermodern capitalism is eroding its own conditions of possibility, intensifying historical injuries and societal fractures, and destabilizing modern assumptions regarding space, time, and security. The supposed end of history that characterized the neoliberal era has morphed into a reckoning with the end of a world—perhaps not the world as such, but the world as it is being made and unmade by the spatial, temporal, racial, linguistic, technological, and imperial drives of hypermodern capitalism, particularly its global, financialized, and algorithmic forms. Scholars of political economy have drawn attention to the fracturing of the neoliberal phase of late capitalism and its hegemonic constellation, and how this fracture has led to a moment of historical uncertainty and transition in the dynamics of power and contestation across societies. Similarly, scholars across the humanities and social sciences have highlighted the existential and political challenges presented by the Anthropocene's apocalyptic implications. This article argues that the dialectical crises of capitalism and ecology are converging in a cultural condition of collective disorientation: a return of history bereft of futurity. Through an analysis of catastrophic precarity in the hypermodern era, the article tracks collective disorientation and catastrophic precarity across four registers—accumulation, time, space, and agency—before ending with a discussion of implications of the analysis for alternative orientations.
Remodeling of organelles and microtubules during spermiogenesis in the liverwort Marchantia polymorpha
Authors: Minamino Naoki , Norizuki Takuya , Mano Shoji , Ebine Kazuo , Ueda Takashi 
Published: August 2022

ABSTRACT
Gametogenesis is an essential event for sexual reproduction in various organisms. Bryophytes employ motile sperm (spermatozoids) as male gametes, which locomote to the egg cells to accomplish fertilization. The spermatozoids of bryophytes harbor distinctive morphological characteristics, including a cell body with a helical shape and two flagella. During spermiogenesis, the shape and cellular contents of the spermatids are dynamically reorganized. However, the reorganization patterns of each organelle remain obscure. In this study, we classified the developmental processes during spermiogenesis in the liverwort Marchantia polymorpha according to changes in cellular and nuclear shapes and flagellar development. We then examined the remodeling of microtubules and the reorganization of endomembrane organelles. The results indicated that the state of glutamylation of tubulin changes during formation of the flagella and spline. We also found that the plasma membrane and endomembrane organelles are drastically reorganized in a precisely regulated manner, which involves the functions of endosomal sorting complexes required for transport (ESCRT) machineries in endocytic and vacuolar transport. These findings are expected to provide useful indices to classify developmental and subcellular processes of spermiogenesis in bryophytes.
Patient perspectives on home-based rehabilitation exercise and general physical activity after total hip arthroplasty: A qualitative study (PHETHAS-2)
Authors: Poulsen Anne Grøndahl , Gravesen Janni Dahlgaard , Madsen Merete Nørgaard , Mikkelsen Lone Ramer , Bandholm Thomas , Rossen Camilla Blach 
Published: August 2022

Background: Home-based rehabilitation exercise following Total Hip Arthroplasty (THA) shows similar outcomes compared to supervised outpatient rehabilitation exercise. Little is known about patients' experiences with home-based rehabilitation, and this study aimed to investigate how patients perceived home-based rehabilitation exercise and general physical activity after THA, focusing on facilitators and barriers. Methods: Semi-structured interviews of qualitative design were conducted with 22 patients who had undergone THA and who had performed home-based rehabilitation exercise. The study took place in a regional hospital in Denmark between January 2018 and May 2019. Data were analyzed using an interpretive thematic analysis approach, with theoretical underpinning from the concept ‘conduct of everyday life’. The study is embedded within the Pragmatic Home-Based Exercise Therapy after Total Hip Arthroplasty-Silkeborg trial (PHETHAS-1). Results: The main theme, ‘wishing to return to the well-known everyday life’, and four subthemes were identified. Generally, participants found the home-based rehabilitation exercise boring but were motivated by the goal of returning to their well-known everyday life and performing their usual general physical activities, though some lacked contact to physiotherapist. Participants enrolled in the PHETHAS-1 study used the enrollment as part of their motivation for doing the exercises. Both pain and the absence of pain were identified as barriers for doing home-based rehabilitation exercise. Pain could cause insecurity about possible medical complications, while the absence of pain could lead to the rehabilitation exercise being perceived as pointless. Conclusions: The overall goal of returning to the well-known everyday life served as a facilitator for undertaking home-based rehabilitation exercise after THA along with the flexibility regarding time and place for performing exercises. Boring exercises as well as both pain and no pain were identified as barriers to the performance of home-based rehabilitation exercise. Participants were motivated towards performing general physical activities which were part of their everyday life.
Using the ‘Twelve tips for applying change models’ for undergraduate medical curriculum reform in Pakistan: Incorporating a new Trauma Evaluation and Management TEAM® course
Authors: Soomro Rufina , Ur Rehman Sheeraz , Ali Sobia , McKimm Judy 
Published: August 2022

Background: Trauma evaluation and management skills are not taught enough in medical school undergraduate curriculums worldwide. It has been recommended by trauma educators to incorporate trauma training in medical schools’ curriculum as first-line management of trauma cases is usually required by junior doctors in ERs. The introduction of formal trauma training in the form of the Trauma Evaluation and Management TEAM® course is a change introduced into the curriculum. Even when introducing such a simple change, certain factors need to be considered including the stakeholders’ apprehensions and involvement, the complexity of the internal and external environment, cultural context and political influences, and finally the psychological impact of change. Methods: Based primarily on the “Twelve tips for applying change models to curriculum design, development and delivery” by McKimm and Jones (2018), these 12 tips provide educators, involved in curriculum or program development, a practical example of the systematic and organized outlines to improve medical curricula. Results & Conclusions: While addressing these factors, this framework can guide educators for the successful development and implementation of a suggested change in the existing curriculum.
Opinions and experiences of physicians regarding complementary and alternative medicine (CAM). A research report from Poland
Authors: Leśniewska Magdalena , Kozioł Ilona , Budzyńska Julia , Kopystecka Agnieszka , Patryn Rafał 
Published: August 2022

Background: The term CAM denotes complementary and alternative medicine. However, CAM is practiced by individuals without academic medical education and formal eligibility for treating people. The extent of interest in CAM is considerable. The WHO global report on traditional and complementary medicine has demonstrated that 87% of all WHO Member States legally recognise individual forms of CAM, and 100 Member States have national policies regarding such practices. In Poland, performing medical activities without appropriate qualifications is prohibited.
Material and Methods: Diagnostic survey distributed as Google Forms was used as the basic research method with the research technique of a questionnaire. The questionnaire starting with a metrics part consisted of several questions regarding popularity and tendency of CAM, causes of CAM popularity, approach to those types of practices and patients as well as role of CAM during the pandemic. Sixty-one responses were obtained from physicians of different age, experience and speciality.
Results: Ninety-five percent (95%) of doctors believe that alternative medicine can be dangerous; 67.2% think that the phenomenon of alternative medicine should be combated; almost half of the physicians surveyed believe that there is a fundamental contradiction between evidence-based medicine (EBM) and alternative medicine. Furthermore, according to 48% of respondents, physicians in Poland should be able to recommend and combine methods of traditional and alternative medicine.
Conclusion: Doctors point to the increasing popularity of CAM among patients in Poland, the consequences of which cannot be determined because there is still a lack of research on the safety of alternative methods. The most frequently cited reasons for interest in CAM suggest that there is a need for a better tailored biomedical approach to individual patient needs.
Improving physiological stability of very preterm babies: a preliminary randomised controlled trial
Authors: Jeffries Suzan , Moss Becky , Modi Neena , Hyde Matthew J , Lammons William 
Published: August 2022

Background Preterm babies born below 32 weeks gestational age are placed in incubators, and therefore deprived of exposure to maternal heartbeat sounds and breathing rhythms. This article explored the use of a unique soft-robotics device that replicates these via a mattress in the incubator. Aims This study aimed to obtain data on mothers' experiences in the NHS COSYBABY study in relation to using the device and learn what, if any, value this device has to parents in the neonatal unit. Methods The study used qualitative focus groups conducted by patient and public involvement leads and interviews with parents. Framework analysis was used to analyse the data. Results Resulting themes were willingness to try anything, supporting mothers, scepticism and searching for causality, limitations of the device and beyond the intervention. Conclusions The device provides socioemotional benefits to mothers of neonatal babies, although the health benefits to their baby are uncertain.
Self-assessed hand and wrist pain and quality of life for postpartum mothers in Japan
Authors: Satoh Tamami , Cadillo Lourdes R Herrera , Ohashi Kazutomo , Onishi Tetsuro 
Published: August 2022

Background Hand and wrist pain can develop during the postpartum period, may be exacerbated by activities during childcare and may continue for several months, leading to chronic upper extremity disability. Little is known about the impact of hand and wrist pain on quality of life in postpartum mothers. Aims This study aimed to explore the relationship between self-assessed hand and wrist pain, upper extremity disability and quality of life among postpartum mothers in Japan. Methods A prospective cohort study was designed for women who had given birth at a general hospital and a clinic in the south of Japan. Participants self-assessed hand and wrist pain using Eichhoff's test and upper extremity disability using the Hand20 questionnaire. General quality of life was assessed with the EQ-5D-5L. Results Self-assessed hand and wrist pain was significantly associated with upper extremity disability. Self-reported subjective and induced pain was associated with lower quality of life. Conclusions Self-assessed hand and wrist pain in postpartum women can significantly lower quality of life. Reporting subjective and self-induced pain helps diagnosis of and may prevent disability, improving a mother's quality of life.
Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures
Authors: Ruberto Anthony A. , Bourke Caitlin , Vantaux Amélie , Maher Steven P. , Jex Aaron , Witkowski Benoit , Snounou Georges , Mueller Ivo 
Published: August 2022

Background
Plasmodium vivax sporozoites reside in the salivary glands of a mosquito before infecting a human host and causing malaria. Previous transcriptome-wide studies in populations of these parasite forms were limited in their ability to elucidate cell-to-cell variation, thereby masking cellular states potentially important in understanding malaria transmission outcomes.

Methodology/Principal findings
In this study, we performed transcription profiling on 9,947 P. vivax sporozoites to assess the extent to which they differ at single-cell resolution. We show that sporozoites residing in the mosquito’s salivary glands exist in distinct developmental states, as defined by their transcriptomic signatures. Additionally, relative to P. falciparum, P. vivax displays overlapping and unique gene usage patterns, highlighting conserved and species-specific gene programs. Notably, distinguishing P. vivax from P. falciparum were a subset of P. vivax sporozoites expressing genes associated with translational regulation and repression. Finally, our comparison of single-cell transcriptomic data from P. vivax sporozoite and erythrocytic forms reveals gene usage patterns unique to sporozoites.

Conclusions/Significance
In defining the transcriptomic signatures of individual P. vivax sporozoites, our work provides new insights into the factors driving their developmental trajectory and lays the groundwork for a more comprehensive P. vivax cell atlas.
Psychometric properties of the item-reduced version of the comprehensive general parenting questionnaire for caregivers of preschoolers in a Finnish context
Authors: Ray Carola , van der Borgh-Sleddens Ester , Augusta de Oliveira Figueiredo Rejane , Gubbels Jessica , Bjelland Mona , Roos Eva 
Published: August 2022

Introduction
Many instruments for assessing general parenting have been reported as burdensome and are thus seldom used in studies exploring children’s energy balance-related behaviors or weight. This study evaluates the factorial structure of the item-reduced version of the Comprehensive General Parenting Questionnaire (CGPQ), which assesses five constructs of general parenting.

Methods
The study uses data from two cross-sectional studies: Study 1 in 2014 (n = 173) and Study 2 in 2015–16 (n = 805). Parents of children aged three to six answered the CGPQ; in Study 1 the 69-item version, and in Study 2 the 29-item version. The reduction was based on the results of the confirmatory factor analyses (CFA) in Study 1. In both datasets, internal consistency, as Cronbach’s alphas and intraclass correlations between the items of each construct, was tested. A combined assessment of the CFA and items response theory evaluated the construct validity and the item importance for the 29-item version, and a further the reduced 22-item version.

Results
In Study 1, the highest Cronbach’s alphas were shown for the five constructs in the 69-item version. A higher intraclass correlation was found between the constructs in the 69- and 29-item versions, than between the 69- and the 22-item version. However, a high concordance was found between the constructs in the 29- and 22-item versions in both Study 1 and in Study 2 (0.76–1.00). Testing the goodness-of-fit of the CFA models revealed that the 22-item model fulfilled all the criteria, showing that it had a better factorial structure than the 29-item model. Standard estimations ranged from 0.20 to 0.76 in the 22-item version.

Conclusion
The reduced 22- and 29-item versions of the 69-item CGPQ showed good model fit, the 22-item version the better of the two. These short versions can be used to assess general parenting without overburdening the respondents.
Prognostic nutritional index as a prognostic factor for renal cell carcinoma: A systematic review and meta-analysis
Authors: Shim Sung Ryul , Kim Sun Il , Kim Se Joong , Cho Dae Sung 
Published: August 2022

Background
Prognostic nutritional index (PNI) is a simple parameter which reflects patient’s nutritional and inflammatory status and reported as a prognostic factor for renal cell carcinoma (RCC). Studies were included from database inception until February 2, 2022. The aim of this study is to evaluate prognostic value of PNI by meta-analysis of the diagnostic test accuracy in RCC.

Methods and findings
Studies were retrieved from PubMed, Cochrane, and EMBASE databases and assessed sensitivity, specificity, summary receiver operating characteristic curve (SROC) and area under curve (AUC). Totally, we identified 11 studies with a total of 7,296 patients were included to evaluate the prognostic value of PNI in RCC finally. They indicated a pooled sensitivity of 0.733 (95% CI, 0.651–0.802), specificity of 0.615 (95% CI, 0.528–0.695), diagnostic odds ratio (DOR) of 4.382 (95% CI, 3.148–6.101) and AUC of 0.72 (95% CI, 0.68–0.76). Heterogeneity was significant and univariate meta-regression revealed that metastasis and cut-off value of PNI might be the potential source of heterogeneity. Multivariate meta-regression analysis also demonstrated that metastasis might be the source of heterogeneity.

Conclusions
PNI demonstrated a good diagnostic accuracy as a prognostic factor for RCC and especially in case of metastatic RCC.