bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel “proximal first” Inoue balloon catheter for retrograde aortic valvuloplasty: Initial case report
Authors: Onishi Takayuki , Fukutomi Motoki , Ando Tomo , Tobaru Tetsuya 
Published: March 2022

AbstractThe Inoue balloon, invented for percutaneous transseptal mitral commissurotomy for mitral stenosis, is initially dilated in the distal portion and then the proximal portion, forming an hourglass shape that stabilizes the balloon at the mitral valve orifice with a pulling action. The device has been successfully applied to antegrade aortic valvuloplasty; the hourglass shape stabilizes the balloon across the aortic valve without rapid ventricular pacing. Subsequently, an Inoue balloon was developed for retrograde aortic valvuloplasty using the same design as the antegrade balloon. The hourglass‐shaped balloon, however, has difficulty maintaining stability across the aortic valve because the distal portion of the balloon, which inflates first, directly receives systolic pressure from the left ventricle. A novel Inoue balloon was invented to overcome this issue by altering the manner of inflation: the proximal portion inflates first, followed by the distal portion. Theoretically, the proximal portion, which initially inflates just above the aortic valve, remains secure across the valve by applying a pressing force that counteracts the systolic forward pressure. Furthermore, a radiopaque marker is placed at the center of the balloon to enable rapid and precise balloon adjustment. We present a case involving a 65‐year‐old female hemodialysis patient with severe symptomatic aortic stenosis who we successfully treated with balloon aortic valvuloplasty using the novel Inoue balloon followed by transcatheter aortic valve implantation. The present case demonstrates the feasibility and effectiveness of the novel “proximal first” Inoue balloon for retrograde balloon aortic valvuloplasty for severe aortic stenosis.
Biomass‐Derived Carbon Quantum Dots‐Induced Self‐Assembly of 3D Networks of Nickel‐Cobalt Double Hydroxide Nanorods as High‐Performance Electrode Materials for Supercapacitors
Authors: Zhuang Jiayuan , Li Gang , Wang Minghe , Li Guifang , Li Yawen , Jia Lishan 
Published: March 2022

AbstractThe nickel‐cobalt double hydroxide hybrid materials induced by biomass‐derived carbon quantum dots (CQDs) have a three‐dimensional network structure of cross‐linked nanorods. The results demonstrate that the functional groups on the CQDs derived from pomelo peel promoted the nucleation and confined the growth of nickel‐cobalt double hydroxide. The as‐synthesized NiCo‐LDH‐CQDs‐20 exhibits the high specific capacitance of 1814 F g−1 at 1 A g−1. When the current density is increased to 15 A g−1, the specific capacitance value remains 75.5 % of the initial one, which indicates that NiCo‐LDH‐CQDs‐20 has an extremely high‐rate performance. Furthermore, the asymmetric supercapacitor NiCo‐LDH‐CQDs‐20//AC provides a high energy density of 46.47 Wh kg−1 in 2 M KOH solution with a power density of 800 W kg−1 and maintains an initial specific capacitance of 82.7 % after 2000 cycles. Therefore, this study provides a promising approach for the development of anode active materials in supercapacitor energy storage devices.
Association between heart rate and cardiovascular death in patients with coronary heart disease: A NHANES‐based cohort study
Authors: Ma Ruicong , Gao Jianbo , Mao Shiyuan , Wang Zhirong 
Published: March 2022

AbstractBackgroundDue to the lack of research, this study aimed to assess the association between the specific range of heart rate and cardiovascular (CV) death in coronary heart disease (CHD) patients.HypothesisHeart rate of 70–79 bpm may be associated with reduced risk of CV death in CHD patients.MethodsThis retrospective cohort study collected the data of CHD patients from the eight cycles of the Health and Nutrition Examination Survey (NHANES). The included patients were divided into four groups: <60, 60–69, 70–79, and ≥80 bpm. The start of follow‐up date was the mobile examination center date, the last follow‐up date was December 31, 2015. The average follow‐up time was 81.70 months, and the longest follow‐up time was 200 months. Competing risk models were developed to evaluate the association between heart rate and CV death, with hazard ratios (HRs) and 95% confidence intervals (CIs) calculated.ResultsA total of 1648 patients with CHD were included in this study. CHD patients at heart rate of <60 (HR, 1.35; 95% CI, 1.34–1.36), 60–69 (HR, 1.05; 95% CI, 1.04–1.06) or ≥80 (HR, 1.39; 95% CI, 1.38–1.41) bpm had a higher risk of CV death than those at heart rate of 70–79 bpm.ConclusionsHeart rate of <70 or ≥80 bpm was associated with an elevated risk of CV death among CHD patients. Continuous monitoring of heart rate may help to screen for health risks and offer early interventions to corresponding patients.
Turgor loss point predicts survival responses to experimental and natural drought in tropical tree seedlings
Authors: Álvarez‐Cansino Leonor , Comita Liza S. , Jones F. Andrew , Manzané‐Pinzón Eric , Browne Luke , Engelbrecht Bettina M. J. 
Published: March 2022

AbstractIdentifying key traits that can serve as proxies for species drought resistance is crucial for predicting and mitigating the effects of climate change in diverse plant communities. Turgor loss point (πtlp) is a recently emerged trait that has been linked to species distributions across gradients of water availability. However, a direct relationship between πtlp and species ability to survive drought has yet to be established for woody species. Using a manipulative field experiment to quantify species drought resistance (i.e., their survival response to drought), combined with measurements of πtlp for 16 tree species, we show a negative relationship between πtlp and seedling drought resistance. Using long‐term forest plot data, we also show that πtlp predicts seedling survival responses to a severe El Niño‐related drought, although additional factors are clearly also important. Our study demonstrates that species with lower πtlp exhibit higher survival under both experimental and natural drought. These results provide a missing cornerstone in the assessment of the traits underlying drought resistance in woody species and strengthen πtlp as a proxy for evaluating which species will lose or win under projections of exacerbating drought regimes.
A Tetracyanobutadiene Spirobifluorene: Synthesis, Enantiomeric Resolution and Chiroptical Properties
Authors: Ozcelik Ani , Pereira‐Cameselle Raquel , Peña‐Gallego Ángeles , Alonso‐Gómez J. Lorenzo 
Published: March 2022

AbstractPush‐pull organic compounds with π‐conjugated backbones are attracting considerable interest in terms of their highly efficient (NLO) non‐linear optical effects. In this respect, cyano groups constitute one of the strongest electron acceptors suitable for NLO materials. We herein report the first 1,1,4,4‐tetracyanobutadiene (TCBD) spirobifluorene (SBF) through a double [2+2] cycloaddition‐retroelectrocyclization. Enantiomeric resolution by HPLC using a chiral stationary phase (CSP) and theoretical calculations unveiled not only the nature of the potential energy surface, but also the absolute configuration of each enantiomer. Since both the presence of strong donor and acceptor, as well as the intrinsic non‐centrosymmetric character of chiral compounds are a prerequisite for the development of NLO properties, the first hyperpolarizability of the developed system was theoretically calculated. The results suggested a strong dependence on the conformation and an intensity enhancement for certain conformers of 1 as compared to its allenic TCBD analogue. Therefore, the present study opens a new class of SBF compounds suitable for NLO applications.
Bimetallic FeCo−N−C Catalyst for Efficient Oxygen Reduction Reaction
Authors: Zhou Meng , Zhu Zhijun , Ju Yuan , Zhai Yanling , Jiao Lei , Liu Minmin , Yang Wenxiu , Tang Jianguo 
Published: March 2022

AbstractOxygen reduction reaction (ORR) is being deeply studied because of its significance in energy storage and conversion. It is an urgent and challenging task to explore low‐cost ORR catalysts with excellent activity and outstanding long‐term stability. Herein, we report an efficient bimetallic FeCo catalyst based on nitrogen‐doped carbon (FeCo−NC) for ORR by pyrolysis of FeCo‐1,10‐phenanthroline complexes (FeCo‐phen) supported on ZIF‐8. The as‐synthesized FeCo−NC catalyst shows excellent ORR activity, improved durability and excellent methanol cross poisoning resistance, which are ascribed to the formation of metal‐N−C active sites, the synergistic effect between Fe and Co, as well as the porous structure.
Decoding microbial genomes to understand their functional roles in human complex diseases
Authors: Wang Yifeng , Dong Quanbin , Hu Shixian , Zou Huayiyang , Wu Tingting , Shi Jing , Zhang Haifeng , Sheng Yanhui , Sun Wei , Kong Xiangqing , Chen Lianmin 
Published: March 2022

AbstractComplex diseases such as cardiovascular disease (CVD), obesity, inflammatory bowel disease (IBD), kidney disease, type 2 diabetes (T2D), and cancer have become a major burden to public health and affect more than 20% of the population worldwide. The etiology of complex diseases is not yet clear, but they are traditionally thought to be caused by genetics and environmental factors (e.g., dietary habits), and by their interactions. Besides this, increasing pieces of evidence now highlight that the intestinal microbiota may contribute substantially to the health and disease of the human host via their metabolic molecules. Therefore, decoding the microbial genomes has been an important strategy to shed light on their functional potential. In this review, we summarize the roles of the gut microbiome in complex diseases from its functional perspective. We further introduce artificial tools in decoding microbial genomes to profile their functionalities. Finally, state‐of‐the‐art techniques have been highlighted which may contribute to a mechanistic understanding of the gut microbiome in human complex diseases and promote the development of the gut microbiome‐based personalized medicine.
In vitro and in vivo methods to study bacterial colonization of hydrogel dermal fillers
Authors: Wang Yi , Borthwell Rachel M. , Hori Kellyn , Clarkson Samuel , Blumstein Gideon , Park Howard , Hart Christopher M. , Hamad Christopher D. , Francis Kevin P. , Bernthal Nicholas M. , Phillips K. Scott 
Published: March 2022

AbstractPreclinical in vitro and in vivo methods to study bacterial interactions with dermal fillers and infection pathogenesis are lacking. In this work, first in vitro methods to assess protein biofouling and effective pore size of commercial dermal fillers, including degradable hyaluronic acid (HA)‐based fillers and other semi‐degradable or permanent fillers (non‐HA), were developed. The results were then related to Staphylococcus aureus (S. aureus) adhesion rates in vitro. HA fillers had less protein sorption than non‐HA fillers and overall had smaller effective pore sizes. The properties correlated with levels of bacterial adhesion, where the control glass surface had the most rapid increase in bacterial cell adhesion, with a slope of 0.29 cm−2 min−1, three unique non‐HA fillers had intermediate adhesion with slopes of 0.11 and 0.06 cm−2 min−1, and three unique HA fillers had the least adhesion with slopes of 0.02, 0.02, and 0.01 cm−2 min−1. S. aureus had greater motility on the HA fillers than on non‐HA fillers. Next, a mouse model for dermal filler biofilm and infection was developed. Mice were inoculated with a controlled amount of bioluminescent bacteria (Xen36 S. aureus) and polyacrylamide hydrogels of different stiffness were injected. In vivo bioluminescence was monitored longitudinally for 35 days to ensure that lasting colonization was established. The inoculum was optimized to achieve adequate bioluminescent signal, and bacterial bioburden over time and inter‐animal variability in bioburden were determined. These in vitro and in vivo approaches can be used for future studies of antimicrobial interventions for dermal fillers.
Group schema therapy for patients with severe anxiety disorders
Authors: Straarup Nanna S. , Renneberg Henriette B. , Farrell Joan , Younan Rita 
Published: March 2022

AbstractThis article presents an adaptation of group schema therapy (GST) developed for patients with severe anxiety. An anonymized case presentation exemplifies the adaptation. GST was originally developed to treat clients with maladaptive personality traits but has been applied to a variety of disorders in recent years. For patients with severe anxiety, who have not responded to other treatments, GST may be a promising approach. The paper presents the GST model, the evidence supporting it, and its adaptation for the treatment of anxiety. The case presentation illustrates the therapeutic process and GST interventions. Finally, the clinical outcome and the implications for implementing GST are discussed.
Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development
Authors: Fish‐Williamson Adi , Hahn‐Holbrook Jennifer , Hobbs Mark , Wallander Jan , Morton Susan M. B. 
Published: March 2022

AbstractBackgroundAntibiotic exposure in pregnancy is associated with reduced microbiome diversity in the infant gut. Given that recent research has shown that early microbiome health can impact child socioemotional development, we examined the relationship between prenatal antibiotic exposure in pregnancy and childhood socioemotional developmental outcomes using a large, nationally representative longitudinal dataset.MethodsA sample of 4800 diverse families were assessed from the population cohort of the Growing Up in New Zealand Study (GUiNZ), which prospectively follows children starting in the last trimester of pregnancy into early childhood. Socioemotional development was measured using a composite score derived from seven commonly used socioemotional tasks administered between 9 months and 4.5 years of child age, addressing emotional expression understanding, regulation of emotions and behavior, and social problem solving and relationship skills. A national comprehensive pharmaceutical database was used to determine children's prenatal antibiotic exposure. Multivariate linear regressions models were used to examine the effects of the timing (trimester) and dosage (number of courses) of prenatal antibiotic exposure on socioemotional development, with and without statistically adjusting for confounding factors addressing maternal health, socioeconomic status, maternal age, and child sex.ResultsIn unadjusted analyses, antibiotic exposure was inversely associated with child socioemotional development. However, after statistically adjusting for important confounds, socioemotional development was not associated with prenatal antibiotic exposure at any dosage or trimester of pregnancy (all β ≤ −0.02).ConclusionPrenatal antibiotic exposure does not appear to impact early childhood socioemotional development. Maternal health and sociodemographic factors are confounded with antibiotic exposure and socioemotional development, a fact that should be considered in future research examining the effects of prenatal antibiotic exposure on child health. These findings may be reassuring to families who are concerned about the long‐term effects of antibiotics in pregnancy on child health outcomes.
Stable isotope differences of polar bears in the Southern Beaufort Sea and Chukchi Sea
Authors: Smith Malia E. K. , Horstmann Lara , Stimmelmayr Raphaela 
Published: March 2022

AbstractThe life‐history, genetic, and habitat use differences between the 2 polar bear (Ursus maritimus) subpopulations in Alaska, USA, have been used to determine the geographic border separating them, but it has sparked a debate of the correct placement of the border for several years. Recently, the Southern Beaufort Sea (SBS) polar bear subpopulation has declined because of sea ice loss, while the Chukchi Sea (CS) subpopulation appears stable. To provide additional information about potential differences between the SBS and CS subpopulations, such as differences in prey sources, we used stable isotope analysis of carbon and nitrogen from bone collagen of polar bears in these 2 neighboring subpopulations. We analyzed polar bear bones from 112 individuals collected from 1954–2019. Our purpose was to determine if the SBS and CS subpopulations could be distinguished based on the stable isotope signatures of bone collagen. A difference >1‰ in stable carbon isotope (δ13C) values suggests a change in carbon sources, such as nearshore to offshore, while a 3‰ change in stable nitrogen isotope (δ15N) values equates to a change of about 1 trophic level. Our study indicated a difference in δ13C values (P ≤ 0.001) but not δ15N values (P = 0.654) between the CS (−13.0 ± 0.3‰ and 22.0 ± 0.9‰, respectively) and SBS bears (−14.7 ± 1.3‰ and 22.2 ± 1.0‰, respectively). Our findings indicate that the 2 subpopulations are consuming similar high trophic level prey, while feeding in ecosystems with different δ13C baselines. We performed a logistic regression analysis using δ13C and δ15N values of the polar bears to predict their placement into these 2 subpopulations. Using Icy Cape, Alaska as the geographical boundary, the analysis correctly placed polar bears in their respective subpopulations 82% of the time. Overall accuracy of placement changed to 84% when using the current geographical boundary at Utqiaġvik, Alaska. We predicted samples collected from the Wainwright, Alaska region as 58% CS and 42% SBS polar bears. This suggests that the area between Wainwright and Icy Cape is a polar bear mixing zone that includes bears from both subpopulations. Bone collagen has a long‐term, potentially life‐long, stable isotope turnover rate, and our results could be used to determine the association of harvested polar bears to Alaska subpopulations, thus aiding in transboundary harvest quota management.
Management of clinically node‐negative glottic squamous cell carcinoma patients according to risk‐scoring model for occult lymph node metastases
Authors: Heng Yu , Xu Chengzhi , Lin Hanqing , Zhu Xiaoke , Zhou Liang , Zhang Ming , Wu Chunping , Tao Lei 
Published: March 2022

AbstractBackgroundGlottic squamous cell carcinoma (GSCC) is the most prevalent type of laryngeal carcinoma. The value of prophylactic lymph node dissection (LND) in resected GSCC remains controversial. This study aims to quantitatively assess the probability of occult lymph node metastasis (LNM) for GSCC patients and devise individualized postoperative radiotherapy strategies.MethodsA total of 1319 patients with GSCC were retrospectively analyzed.ResultsGSCC patients with T1‐T2 stages showed significantly lower LNM rate than those with T3‐T4 stages. For patients with T3‐T4 GSCC, multivariate logistic analyses indicated that three factors—maximum tumor diameter (MTD) of more than 2.0 cm, relatively low differentiation, and tumor invasive depth of no less than 1.0 cm—were independent risk factors for the existence of LNM. A predictive nomogram was established based on these factors. The accuracy and validity of our model were verified by 0.716 and remained at 0.717 after 1000 bootstrapping. The calibration curve was also plotted and showed a favorable agreement. The patients were stratified into two groups based on their individual LNM risk points. Possible LNM rates for low‐risk and high‐risk subgroups were 4.7% and 25.2%, respectively.ConclusionsA new post‐operative strategy selection flow chart was established based on our newly created nomogram which can effectively predict the individualized possibility of occult LNM for GSCC patients. For clinical T3‐4N0 patients in the high‐risk subgroup, prophylactic dose post‐operative radiation therapy is recommended. However, for all those clinically diagnosed as T1‐2N0 stage, regular follow‐up is sufficient in view of the low occult LNM rate.Level of Evidence: 2a
Saved by the past? Disease threat triggers nostalgic consumption
Authors: Barauskaitė Dovilė , Gineikienė Justina , Fennis Bob M. 
Published: March 2022

AbstractRecent research views nostalgia as a valuable resource that can be accessed in times of distress and discomfort. The present work complements this literature by examining novel and previously uncovered triggers and downstream consequences of nostalgia in the consumer domain: disease‐threat and protective behavior. The current paper argues that nostalgia functions as such a psychological resource with buffering qualities and is used as a coping mechanism to maintain comfort when experiencing disease threat—the perception of a potential threat posed by an infectious disease. Using an archival data set and five experiments, the authors demonstrate that when facing a disease threat, but not an actual occurrence of disease, consumers experience a higher need for nostalgia and show an increased preference for nostalgic products. That is, internet searches for nostalgic products rise during flu season as well as COVID‐19 pandemic (Study 1), disease threat induces increased levels of experienced nostalgia (Study 2), which translate into increased preferences for nostalgic products (Study 3 and Study 5), mediated by disgust (Study 4). Finally, the authors show the resource value of product‐induced nostalgia, demonstrating the ironic effect that it can compensate for disease‐protective behavior (Study 6). The results provide important practical implications for marketers and policy‐makers who could focus on promoting nostalgic products or incorporating nostalgic cues in product design and communication that would generate positive consumer evaluations when the threat of illness or disease is salient.
The late Archaean to early Proterozoic origin and evolution of anaerobic methane‐oxidizing archaea
Authors: Wang Yinzhao , Xie Ruize , Hou Jialin , Lv Zhenbo , Li Liuyang , Hu Yaoxun , Huang Hungchia , Wang Fengping 
Published: March 2022

Impact statementMicroorganisms, called anaerobic methane‐oxidizing archaea (ANME), can reduce a large amount of greenhouse gas methane and therefore have the potential to cool the Earth. We collected nearly all ANMEs genomes in public databases and performed a comprehensive comparative genomic analysis and molecular dating. Our results show that ANMEs originated in the late Archaean to early Proterozoic eon. During this period of time, our planet Earth was experiencing the Great Oxygenation Event and Huronian Glaciation, a dramatic drop in the Earth's surface temperature. This suggests that the emergence of ANMEs may contribute to the reduction of methane at that time, which is an unappreciated potential cause that led to the Huronian Glaciation.