bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sledding Accidents at a Level 1 Pediatric Trauma Center Between 2006 and 2016
Authors: Ryan Sydney , Fenton Stephen J. , Hansen Kris , Hewes Hilary A. 
Published: April 2022

Background
Sledding is not a risk-free winter sport. According to the US Consumer Product Safety Commission, there were an estimated 13,954 sledding accidents requiring medical care in 2010. However, specific information concerning pediatric injuries related to sledding is not well defined.

Objectives
This study aimed to identify the most common types of injuries associated with sledding accidents and demographic factors related to risk of injury in pediatric patients, and to compare injuries associated with 2 different age groups and sexes.

Methods
This is a retrospective descriptive study of pediatric patients (<18 years of age) presenting to a regional level I pediatric trauma center secondary to a sledding injury between 2006 and 2016. Demographic information including sex, age, mechanism of injury, and injury severity score was captured and analyzed using descriptive statistics.

Results
There were 209 patients identified for 10 years. There were no mortalities. There were 85 patients with primary head injury, of which 82 (96.5%) were hospitalized and 33 (38.8%) required an intensive care unit (ICU) stay. Seventy-five patients primarily suffered from extremity injuries, of which 56 (74.6%) had lower extremity fractures requiring operative intervention. There was no difference in ICU or length of stay between younger children (0–11 years) and adolescents (12–18 years) or between male and female patients.

Conclusions
Childhood sledding can result in a variety of significant injuries requiring surgical intervention and hospitalization. Children pulled on sleds behind motorized vehicles are at higher risk for more severe injuries resulting in a higher rate of ICU admission.
Value of Temperature for Predicting Invasive Bacterial Infection in Febrile Infants
Authors: de la Torre Mercedes , Gómez Borja , Velasco Roberto ,   on behalf of the Group for Study of Febrile Infant of Spanish Pediatric Emergency Research Group (RISeuP-SPERG)
Published: April 2022

Objective
This study aimed to analyze the prevalence of invasive bacterial infection (IBI) among infants younger than 90 days with fever without source according to the degree of fever.

Methods
We performed a secondary analysis of a multicenter study with 19 participating Spanish pediatric emergency departments that included 3401 febrile infants 90 days or younger.

Results
Prevalence of IBI was 3.2% (5.3% among infants <29 days old, 2.5% among those 29–60 days old, and 2.2% among those 61–90 days old). Prevalence of bacteremia increased with the degree of fever, meanwhile the prevalence of bacterial meningitis did not. No cutoff point was useful for ruling out an IBI safely. Overall, 46.7% of the IBIs were diagnosed in patients with temperature <38.6° (sensitivity, 53.3%; negative likelihood ratio, 0.81).

Conclusions
Performing blood tests should be recommended in infants 90 days or younger with temperature ≥38°C without source regardless of the degree of fever.
Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: a retrospective cohort study
Authors: Hebert Anne , Simons Annet , Schuurs-Hoeijmakers Janneke H.M. , Koenen Hans J.P.M. , Zonneveld-Huijssoon Evelien , Henriet Stefanie S.V. , Schatorjé Ellen J.H. , Hoppenreijs Esther P.A.H. , Leenders Erika K.S.M. , Janssen Etienne J.M. , Santen Gijs W.E. , de Munnik Sonja A. , van Reijmersdal Simon V. , van Rijssen Esther , Kersten Simone , Netea Mihai G. , Smeets Ruben L. , van de Veerdonk Frank L. , Hoischen Alexander , van der Made Caspar I. 
Published: April 2022

AbstractBackgroundDe novo variants (DNVs) are currently not routinely evaluated as part of diagnostic whole exome sequencing (WES) analysis in patients with suspected inborn errors of immunity (IEI).MethodsThis study explored the potential added value of systematic assessment of DNVs in a retrospective cohort of 123 patients with a suspected sporadic IEI who underwent patient-parent trio-based WES.ResultsA likely molecular diagnosis for (part) of the immunological phenotype was achieved in 12 patients with the diagnostic in silico IEI WES gene panel. Exome-wide evaluation of rare, non-synonymous DNVs affecting coding or splice site regions led to the identification of 14 candidate DNVs in genes with an annotated immune function. DNVs were identified in IEI genes (NLRP3 and RELA) and potentially novel candidate genes, including PSMB10, DDX1, KMT2C and FBXW11. The FBXW11 canonical splice site DNV, in a patient with autoinflammatory disease, was shown to lead to defective RNA splicing, increased NF-κB p65 signalling, and elevated IL-1β production in primary immune cells.ConclusionsThis retrospective cohort study advocates the implementation of trio-based sequencing in routine diagnostics of patients with sporadic IEI. Furthermore, we have provided functional evidence supporting a causal role for FBXW11 loss-of-function mutations in autoinflammatory disease.FundingThis research was supported by grants from the European Union, ZonMW and the Radboud Institute for Molecular Life Sciences.
Safety and feasibility of an FES-Cycling based neuromuscular evaluation method in mechanically ventilated patients
Authors: Figueiredo Thainá de Gomes , Frazão Murillo , Werlang Luís Augusto , Azevedo Cássio , Kunz Adelar , Peltz Maikel , Câmara Furtado Veridiana , de Souza Edgar Brito , de Moura Júlio Francisco , Silva Rosane Maria , Sobral Filho Dário Celestino 
Published: April 2022

AbstractPurposeFES-Cycling can be used to assess neuromuscular performance, however the safety and feasibility of this evaluation method has never been investigated.Materials and methodsan observational prospective study was carried out. The FES-Cycling equipment was set in the evaluation mode. For safety determination, hemodynamic parameters and peripheral oxygen saturation were measured before and immediately after the evaluation protocol, as well as venous oxygen saturation and blood lactate. The creatine phosphokinase level (CPK) was measured before and 24, 48 and 72 hours after the test. The time spent to carry out the entire evaluation protocol and the number of patients with visible muscle contraction were recorded to assess feasibility.ResultsHeart rate, systolic and diastolic blood pressure did not change after protocol evaluation, as well as peripheral and venous oxygen saturation (p > 0.05). Moreover, blood lactate did not change (p > 0.05). CPK did not change up to 72 hours after the test (p > 0.05). The time for evaluation was 11.3 (SD = 1.1) minutes. Furthermore, 75% of the patients presented very visible muscle contraction, 25% of the patients presented barely visible and no patients presented non-visible muscle contraction.ConclusionsFES-Cycling based neuromuscular evaluation method is safe and feasible.
Triangulating Causality Between Childhood Obesity and Neurobehavior: Twin and Longitudinal Evidence
Authors: Kulisch Leonard Konstantin , Arumäe Kadri , Briley D. A. , Vainik Uku 
Published: April 2022

AbstractObjectiveChildhood obesity is a serious health concern that is not yet fully understood. Previous research has linked obesity with neurobehavioral factors such as behavior, cognition, and brain morphology. The causal directions of these relationships remain mostly untested.MethodsWe filled this gap by using the Adolescent Brain Cognitive Development study cohort comprising 11,875 children aged 9–10. First, correlations between body mass percentile and neurobehavioral measures were cross-sectionally analyzed. Effects were then aggregated by neurobehavioral domain for causal analyses. Direction of Causation twin modeling was used to test the direction of each relationship. Findings were validated by longitudinal cross-lagged panel modeling.ResultsBody mass percentile correlated with measures of impulsivity, motivation, psychopathology, eating behavior, and cognitive tests (executive functioning, language, memory, perception, working memory). Higher obesity was also associated with reduced cortical thickness in areas of the frontal and temporal lobe but with increased thickness in parietal and occipital brain areas. Similar although weaker patterns emerged for cortical surface area and volume. Twin modeling suggested causal effects of childhood obesity on eating behavior (β=.26), cognition (β=.05), cortical thickness (β=.15), and cortical surface area (β=.07). Personality/psychopathology (β=.09) and eating behavior (β=.16) appeared to causally influence childhood obesity. Longitudinal evidence broadly supported these findings. Results regarding cortical volume were inconsistent.ConclusionsResults supported causal effects of obesity on brain functioning and morphology, consistent with effects of obesity-related brain inflammation on cognition. The present study highlights the importance of physical health for brain development during childhood and may inform interventions aimed at preventing or reducing pediatric obesity.
Berberine Bridge Enzyme-Like Oligosaccharide Oxidases Act As Enzymatic Transducers Between Microbial Glycoside Hydrolases and Plant Peroxidases
Authors: Scortica Anna , Giovannoni Moira , Scafati Valentina , Angelucci Francesco , Cervone Felice , De Lorenzo Giulia , Benedetti Manuel , Mattei Benedetta 
Published: April 2022

ABSTRACTOG-oxidases (OGOXs) and CD-oxidase (CELLOX) are plant berberine bridge enzyme-like oligosaccharide oxidases that oxidize oligogalacturonides (OGs) and cellodextrins (CDs), cell wall fragments with nature of damage-associated molecular patterns (DAMPs). The oxidation of OGs and CDs attenuates their elicitor activity by concomitantly releasing H2O2. Here, we demonstrate that the H2O2 generated downstream of the combined action between a fungal polygalacturonase and OGOX1 or an endoglucanase and CELLOX can be directed by plant peroxidases (PODs) either towards a reaction possibly involved in plant defence such as the oxidation of monolignol or a reaction possibly involved in a developmental event such as the oxidation of auxin (IAA), pointing to OGOX1 and CELLOX as enzymatic transducers between microbial glycoside hydrolases and plant PODs.
Accelerated mass transfer from frozen thin films during thin-film freeze-drying
Authors: Wang Jie-Liang , Kuang Manlei , Xu Haiyue , Williams Robert O. , Cui Zhengrong 
Published: April 2022

AbstractFreeze-drying, or lyophilization, is widely used to produce pharmaceutical solids from temperature-sensitive materials but the process is time and energy inefficient. Herein, using E. coli as a model live organism, whose viability in dry powders is highly sensitive to the water content in the powders, we demonstrated that the drying rate of thin-film freeze-drying (TFFD) is significantly higher than that of the conventional shelf freeze-drying, likely because the large total surface area from the loosely stacked frozen thin films and the low thickness of the thin-films enable faster and more efficient mass transfer during freeze-drying. The highly porous nature and high specific surface area of the thin-film freeze-dried powders may have contributed to the faster mass transfer as well. Moreover, we demonstrated that TFFD can be applied to produce dry powders of E. coli and L. acidophilus with minimum bacterial viability loss (i.e., within one log reduction), and the L. acidophilus dry powder is suitable for intranasal delivery. It is concluded that TFFD technology is promising in addressing the time-and cost-inefficient issue of conventional shelf freeze-drying.
Peptidergic signaling controls the dynamics of sickness behavior inCaenorhabditis elegans
Authors: Marquina-Solis Javier , Vandewyer Elke , Hawk Josh , Colón-Ramos Daniel A. , Beets Isabel , Bargmann Cornelia I. 
Published: April 2022

SUMMARYPathogenic infection elicits sickness behaviors that promote recovery and survival of the host. For example, following infection with the pathogenic bacteriumPseudomonas aeruginosaPA14, the nematodeCaenorhabditis elegansmodifies its sensory preferences to avoid the pathogen. Here we identify antagonistic neuromodulatory circuits that shape this sickness behavior. Using an unbiased cell-directed neuropeptide screen, we show that AVK neurons upregulate and release FMRFamide-like FLP-1 neuropeptides during infection to drive pathogen avoidance. Manipulations that increase or decrease AVK signaling accelerate or delay pathogen avoidance, respectively, implicating AVK in the dynamics of sickness behavior. FLP-1 neuropeptides act via the G-protein-coupled receptor DMSR-7 in RIM/RIC neurons to reduce tyraminergic/octopaminergic signaling that opposes pathogen avoidance. RIM/RIC neurons relay parallel signals from neuropeptides and the cytokine TGF-β that represent internal and external regulators of pathogen avoidance. Our results demonstrate that antagonism between neuromodulatory systems results in slow, graded transitions between alternative behavioral states.
Dual orexin antagonist DORA-22 suppressed posttraumatic seizures and enhances GABAergic inhibition in dentate granule cells
Authors: Konduru Sruthi R. , Isaacson Jesse R. , Zhou Zihao , Rao Rohan K. , Lasky Danny J. , Vattem Swati S. , Rewey Sophie J. , Jones Mathew V. , Maganti Rama K. 
Published: April 2022

AbstractBackgroundTraumatic brain injury (TBI) can result in posttraumatic epilepsy (PTE) and sleep disturbances. We hypothesized that treatment with sleep aids after TBI can ameliorate PTE.MethodsCD-1 mice underwent controlled cortical impact (CCI), sham craniotomy or no craniotomy. Sham and CCI groups underwent a month-long treatment with sleep aids including a dual orexin antagonist (DORA-22) or THIP (gaboxadol). We performed week-long EEG recordings during week-1 of treatment and again at months 1, 2 and 3. Seizure analysis occurred at all-time points and sleep analysis occurred in week-1 and month-1 recordings in all groups. Subsets of animals in sleep aid-treated and untreated CCI, and sham groups were subjected to voltage clamp experiments.ResultsDORA-22 treated group had seizures at week-1 but none at months 1-3. TBI reduced amplitude and frequency of miniature inhibitory synaptic currents (mIPSCs) in dentate granule cells and these changes were rescued by DORA-22 treatment. Sleep analysis showed that DORA-22 increased non-rapid eye movement sleep (NREM) in the first 4hours of lights-off whereas THIP increased REM sleep in the first 4-hours of lights-on in week-1, At month-1 both treatments reduced time in NREM during lights-off. TBI increased NREM delta power (NΔ) along with loss of the homeostatic overnight decline of NΔ in week-1 regardless of treatment. DORA-22 and THIP treatment restored NΔ to levels similar to no craniotomy animals at month-1.ConclusionsDORA-22 treatment suppressed posttraumatic seizures possibly due to enhanced GABAergic inhibition in dentate granule cells. DORA-22 may have therapeutic potential in suppressing PTE.Summary for Social MediaTraumatic brain injury (TBI) can result is posttraumatic epilepsy and sleep disturbances. There are no treatments to prevent these complications. We tested whether treatment with sleep aids after TBI can mitigate seizures and sleep disturbances. We found that a sleep aid DORA-22 but not THIP suppressed post traumatic seizures possibly be enhancing GABAergic inhibition in the hippocampus. Sleep analysis showed that TBI disrupts the sleep homeostatic drive and DORA treatment restored it. Findings may lead to potential disease modifying therapy for posttraumatic epilepsy.
Exploring customer stewardship behaviors in service firms
Authors: Boateng Henry , Amenuvor Fortune Edem , Adam Diyawu Rahman , Agbemabiese George Cudjoe , Hinson Robert E. 
Published: April 2022

PurposeThe existing literature has emphasized the importance of frontline service employees developing a sense of ownership for the overall well-being of customers. However, studies into why frontline service employees develop ownership and responsibility for customers are still lacking. The purpose of this paper is to address the question, “Why do frontline service employees engage in responsible customer service behaviors and protect the interests of customers in Ghana?"Design/methodology/approachA semistructured interview with 61 frontline service employees was used in the study. This study used a thematic analysis technique to analyze the data.FindingsThe findings show that frontline service employees develop a sense of customer stewardship because of organizational values, human resource management initiatives (rewards and in-service training) and ownership and accountability.Originality/valueStudies on why frontline service employees engage in responsible customer service behaviors and protect the interests of customers is limited. This study addresses this gap in the literature.
Applying pricing research in B2B financial service industries
Authors: Indounas Kostis 
Published: April 2022

PurposeThe purpose of this research paper is to investigate the extent to which companies that operate in business-to-business (B2B) financial service markets adopt any form of pricing research along with the different pricing objectives that they pursue in comparison with companies that do not adopt such kind of research.Design/methodology/approachTo achieve the research objectives, data were collected from 143 companies operating in three different B2B financial service industries.FindingsThe findings of the study indicate that companies that adopt any form of pricing research are mainly based on historical sales data and personal in-depth interviews. Moreover, they focus more on both company and market related pricing objectives than those companies that do not adopt such pricing research methods when setting their prices.Practical implicationsThe above findings indicate that the managers responsible for setting prices within their firms might have to gain a lot by adopting a research orientation when setting their prices, since such orientation may lead them to a more holistic approach regarding pricing decision-making by focusing on both company and market related issues.Originality/valueGiven the lack of similar studies in the existing B2B financial services literature, the value of the paper is that it represents one of the first attempts to empirically examine this issue.
Short-run effects of hurricanes on the housing markets: evidence from Florida
Authors: Dogan Can , Hattapoglu Mustafa , Hoxha Indrit 
Published: April 2022

Purpose
Many studies have shown that the intensity and the number of hurricanes are likely to increase. This paper aims to look at the immediate effects of hurricanes on the time on the market, share of houses sold and percentage of houses with price cuts in the housing market using the metropolitan statistical area-level data in Florida.

Design/methodology/approach
Using a difference-in-difference method, the authors estimate the impact that a hurricane has on the housing markets.

Findings
The authors find that a hurricane has a positive and significant effect on the time on the market. A hurricane leads to a delay of the sale of a typical house in Florida by five days. The authors test for within-year seasonality and show that these effects change with seasonality of the housing market. Markets with seasonal housing prices tend to be affected more by hurricanes than those where housing prices are not seasonal. The authors also show that effects of a hurricane are transient and fade away in a few months. The results remain significant as the hurricane intensity changes.

Originality/value
This is the first study to look at the short-term effects of the hurricanes and how their effects vary based on seasonality of the markets.
Research on electronic word-of-mouth for product and service quality improvement: bibliometric analysis and future directions
Authors: Wang Yajun , Meng Xinyu , Xu Chang , Zhao Meng 
Published: April 2022

PurposeThis paper aims to analyze high-quality papers on the research of electronic word-of-mouth (eWOM) for product and service quality improvement from 2009 to 2022, in order to fully understand their historical progress, current situation and future development trend.Design/Methodology/ApproachThis paper adopts the bibliometrics method to analyze the relevant literature, including publishing trend and citation status, regional and discipline area distribution, and influential publications. Secondly, the VOSviewer is used for literature co-citation analysis and keyword co-occurrence analysis to obtain the basic literature and research hotspots in this research field.FindingsFirstly, the study finds that the number of publications basically shows an increasing trend, and those publications are mainly published in tourism journals. In addition, among these papers, China has the largest number of publications, followed by the USA and South Korea. Through co-citation analysis of literature and keyword co-occurrence analysis, 22 foundational papers and six main research topics are obtained in this paper. Finally, this paper elaborates on the development trend of the research topic and future research directions in detail.Originality/valueThis is the first paper that uses bibliometrics to analyze and review relevant researches on eWOM for product and service quality improvement, which is helpful for researchers to quickly understand its development status and trend. This review also provides some future research directions and provides a reference for further research.
Fostering firm resilience through organizational ambidexterity capability and resource availability: amid the COVID-19 outbreak
Authors: Gayed Salma , El Ebrashi Raghda 
Published: April 2022

Purpose
This study aims to study the impact of organizational ambidexterity capability and resource availability on firm resilience along with perceived environmental uncertainty playing a moderating role. This study also intends to investigate the interplaying relationship between exploration capability and exploitation capability as components of organizational ambidexterity with resource availability.

Design/methodology/approach
Quantitative data was collected through self-administered surveys targeting 202 firms in Egypt. SEM (AMOS-SPSS) was used to test the proposed hypotheses.

Findings
The results indicated that both organizational ambidexterity capability and resource availability impact firm resilience. Moreover, the relationship between the enablers was found to be significant, where resource availability has a positive impact on the firm’s exploitation capability, the firm’s exploitation capability has a positive impact on its exploration capability and finally, the firm’s exploration capability has a positive impact on resource availability. However, the moderating role of perceived environmental uncertainty was found to be insignificant.

Research limitations/implications
Nonprobability convenience sampling technique, cross-sectional design and the relatively small sample size may hinder the ability to generalize this study.

Practical implications
This study identifies the importance of exploration (innovation) and exploitation (efficiency) capabilities for managers to build responsive organizations.

Originality/value
This study contributes to the understanding of firm resilience in times of uncertainties, where empirical research has not been enough. In addition, this study contributes to the identification of possible antecedents of firm resilience, highlighting the importance of certain strategic features including organizational ambidexterity capability and resource availability. This study also investigates the relationship between exploitation capabilities, exploration capabilities and resource availability, which was not empirically tested in the literature.