bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha-1 antitrypsin protects against phosgene-induced acute lung injury by activating the ID1-dependent anti-inflammatory response
Authors: He Gaihua , Yu Weihua , Li Hongwei , Liu Jiangzheng , Tu Yongmei , Kong Deqin , Long Zi , Liu Rui , Peng Jie , Wang Zhao , Liu Penghui , Hai Chunxu , Yan Wenjun , Li Wenli 
Published: December 2022

Abstract
Phosgene, a highly dangerous chemical warfare agent, is widely used as an industrial chemical. Phosgene inhalation causes acute lung injury (ALI), which may further progress into pulmonary edema. Currently, there is no known antidote for phosgene poisoning. Alpha-1 antitrypsin (α1-AT) is a protease inhibitor that has been used to treat emphysema patients, who are deficient in α1-AT, for decades. Recent studies have shown that α1-AT has both anti-inflammatory and anti-SARS-CoV-2 effects. In this study, we aimed to investigate the role of α1-AT in phosgene-induced ALI. We observed a time-dependent increase in α1-AT expression and secretion in the lungs of rats exposed to phosgene. Interestingly, α1-AT was derived from neutrophils, but not from macrophages or alveolar type II cells, and α1-AT knockdown aggravated phosgene- and lipopolysaccharide (LPS)-induced inflammation and cell death in human bronchial epithelial cells (BEAS-2B). Conversely, α1-AT administration suppressed the inflammatory response and prevented death in LPS- and phosgene-exposed BEAS-2B cells. Furthermore, α1-AT treatment increased the expression of the inhibitor of DNA binding (ID1) gene, which suppressed NF-κB pathway activation, reduced inflammation, and inhibited cell death. These data demonstrate that neutrophil-derived α1-AT protects against phosgene-induced ALI by activating the ID1-dependent anti-inflammatory response. This study may provide novel strategies for the treatment of patients with phosgene-induced ALI.
Correlation between PAPP-A levels determined during the first trimester and birth weight at full-term.
Authors: Sánchez Elena Turrado , Sánchez Virginia de Miguel , Cortiñas Manuel Macia 
Published: December 2022

Abstract
Introduction: Foetal birth weight is an important determinant of perinatal health. For this reason, various methods have been investigated for estimating this weight during pregnancy.
Aims: The aim of this study is to evaluate the possible relationship between full-term birth weight and PAPP-A levels determined during the first trimester as part of combined screening for aneuploidy carried out in pregnant women.
Material and methodology We carried out a single-centre study including pregnant women who were being followed up by the Obstetrics Service Care Units of the XXI de Santiago de Compostela e Barbanza Foundation, who gave birth from 1 March 2015 to 1 March 2017, and who had undergone their first-trimester combined chromosomopathy screening (or first-trimester combined screening, FTCS). The sample included a total of 2794 women.
Results: When we analysed the relationship between foetal birth weight and the parameters used during first-trimester combined screening, as well as investigating into a predictor role for these parameters, we found a significant correlation between MoM PAPP-A and foetal birth weight. When MoM PAPP-A was measured at extremely low levels (< 0.3) during the first trimester, the OR for giving birth to a foetus with weight < p10, adjusting for gestational age and sex, was 2.74. For low levels of MoM PAPP-A (0.3 - 0.44), the OR was 1.52. With regard to the value of MOM PAPP-A levels as a predictor of foetal macrosomia, a correlation could be observed with elevated levels, although this was not statistically significant.
Conclusions: PPAP-A determined during the first trimester acts as a predictor of foetal weight at term, as well as for foetal growth disorders.
Remdesivir Administration for Sars Cov 2 Pneumonia in Icu and Non- Icu Patients: Outcome and Post-treatment Differences
Authors: Sabba Antonio , Pontoni Giancarlo , Santangelo Maria , Rachedi Nadir , D’Ercole Maurizio , Marseglia Bernardino , Fusaro Marcella , Fontana Costantino 
Published: December 2022

Abstract
Purpose
This prospective observation and monocentric study aims to verify the outcome (Healing/Death) of Remdesivir, a nucleotide analogue prodrug of adenosine, for two hospital patients groups: patients in standard oxygen therapy and patients undergoing mechanical ventilation.
Methods
449 patients affected by Covid-19 were hospitalized at the Rome Military Hospital between March 2020 and July 2022. Depending on the severity of the disease they were assigned either to the Functional Health Emergency Unit (UFES) - if suffering from interstitial pneumonia with a clinical manifestation of dyspnoea associated with peripheral oxygen saturation < 92%, and oxygen atmospheric pressure therapy - or to the Intensive Care Unit (ICU) - if the blood gas-lytic index P/F (ratio between partial pressure of arterial O2 and inspired fraction of O2) was below 150. The two patient categories were further separated into a study group undergoing Remdesivir therapy and a control group treated alternatively with Lopinavir/Ritonavir either Hydroxychlorochina or Tocilizumab.
Results
The results highlight the importance of the adoption of Remdesivir in the initial stages of infection to prevent the systemic spread and viral multiplication and, in the subsequent phase, a cytokine storm resulting in acute respiratory failure and multi organ failure. The use of the drug in the most advanced stages of the disease is not associated with a real impact on patient outcomes. Therefore, there is a statistically significant correspondence between the early use of remdesevir in the treatment of Sars Cov 2 disease - in addition to guidelines therapies - and a favorable clinical outcome.
In Vitro High-Throughput Toxicological Assessment of E-Cigarette Flavors in Human Bronchial Epithelial Cells and the role of TRPA1 in Cinnamon Flavor-Induced Toxicity
Authors: Effah Felix , Taiwo Benjamin , Baines Deborah , Bailey Alexis , Marczylo Tim 
Published: December 2022

Abstract
Background
Electronic cigarettes (ECs) are considered a less hazardous alternative to tobacco smoking but are not harmless. Growing concerns about the safety profiles of flavors in e-liquids underpin the need for this study.
Methods
Here, we screened 53 nicotine-free flavored e-liquids (across 15 flavor categories) across a 3-point concentration range (0.25%, 0.5%, and 1% v/v) in a high-throughput fashion in human bronchial epithelial (HBEC-3KT) submerged cell cultures to identify ‘toxic hits’ using in vitro endpoint assays comprising cell count, cell viability, and lactate dehydrogenase (LDH).
Results
We observed significant, dose-dependent adverse effects only with cinnamon, vanilla tobacco, and hazelnut e-liquids compared to media-only control and PG/VG vehicle controls. Hence, we further analyzed these three flavors for their effects on HBEC-3KT proliferation, mitochondrial health, and oxidative stress. A significant decrease in cell proliferation after 36h was observed for each e-liquid toxic hit compared to media-only and PG/VG controls. Hazelnut (at all concentrations) and vanilla tobacco (1%) increased cytoplasmic reactive oxygen species (ROS) generation compared to media-only and PG/VG controls. Conversely, all three flavors at 0.5% and 1% significantly decreased mitochondrial membrane potential (MP) compared to PG/VG and media-only controls. We hypothesized that the cytotoxic effects of cinnamon flavor in e-liquids might be mediated via the transient protein receptor ankyrin subtype 1 (TRPA1); however, TRPA1 antagonist AP-18 (10 µM) did not mitigate these effects, and cinnamon significantly increased TRPA1 transcript levels. Therefore, pathways that mediate cinnamon’s cytotoxicity warrant further investigations.
Conclusion
This study could inform public health authorities on the relative health risks assessment following exposure to EC flavor ingredients.
The Role of Ramus Intermedius in Atherosclerosis Plaque Deposition at the Left Bifurcation Region: A Retrospective Study using Coronary Computed Tomography Angiography
Authors: ROSANI NURUL SAZMI , Zamin Rasheeda Mohd , Zulkafli Intan Suhana , Aman Raja Rizal Azman Raja , Zuhdi Ahmad Syadi Mahmood , Danaee Mahmoud 
Published: December 2022

Abstract
Ramus intermedius (RI) is a coronary artery anatomical variant arising from the left main bifurcation angle coursing between the left anterior descending and left circumflex arteries. RI is commonly reported in coronary artery investigations, but its role in coronary artery disease (CAD) is unknown. The objective of this study is to evaluate the contributory effects of the RI in the development of CAD at the left bifurcation region (LBR) using coronary computed tomography angiography (CCTA). A retrospective cross-sectional single-centre study was conducted on patients who underwent CCTA from January 2017 until December 2018. A total of 374 patients were included based on inclusion and exclusion criteria. The left main coronary artery (LMCA), proximal left anterior descending (pLAD), and proximal left circumflex (pLCx) arteries were analysed against known cardiovascular risks (CVR) (i.e., Absence or Presence). The RI was identified in 32% of patients (n = 121). RI singularly increases the risk for plaque deposition at the LMCA and pLAD but not in the pLCx. RI increased the risk for LMCA stenosis by eight-fold (Adjusted OR, aOR: 8.5, 95% CI: 1.7, 43.0, p = 0.010). At the pLAD, a RI increased the risk for plaque deposition at the lateral wall by three-fold (aOR: 3.5, 95% CI: 1.1, 11.3, p = 0.036) and four-fold for plaque formation on both lateral and medial walls (aOR: 4.3, 95% CI: 2.7, 17.2, p = 0.038). These findings suggested for the first time that RI pose an elevated risk for atherosclerosis in coronary arteries.
A study of the effect of Graphene on the Fatigue Life of CuAlNi Shape Memory Alloy
Authors: Issa Wasiu Ayinde , Çamur Hüseyin , Savaş Mahmut 
Published: December 2022

Abstract
CuAlNi shape memory alloys (SMA) find usefulness in high temperature engineering applications. They have ease of production and are cheap in comparison with Nickel-Titanium alloys. The alloy is usually under cyclic load/stress but lacks excellent fatigue properties. In this study, the effect of graphene (C) on the fatigue life of CuNiAl SMA was investigated. The resulting S-N curves revealed that as the number of stress cycles increases, the magnitude of stress leading to fatigue failure reduces. CuAlNi SMA containing 0.3% graphene showed an improved fatigue life at 1649.25MPA. Design Expert Software version 13.0 was deployed to predict the interaction between fatigue life, percentage composition; of Cu, Al, Ni, graphene (C), and applied stress. These parameters (%Cu, %Al, %Ni, %C, σ) were significant model terms at p < 0.05, indicating that they have significant effect on the fatigue life of SMA and the mathematical model indicated a good fit with R 2 of 0.9058. The developed model can be employed in fatigue life study of shape memory alloy containing a fourth addition such as graphene.
Uveitis, a Rare but Important Complication of adjuvant Zoledronic acid in breast cancer
Authors: Chacko Geena , Kota Srigowri , Kumar Shicha , Ohri Nisha , Omene Coral , Toppmeyert Deborah L. , Ganesan Shridar , George Mridula 
Published: December 2022

Abstract
Adjuvant therapy has become a crucial part in reducing risk of recurrence after surgical intervention. Bisphosphonates such as zoledronic acid have been used as part of adjuvant therapy. Among its many side-effects, zoledronic acid also carries a risk of uveitis. Uveitis remains one of many lesser-known side-effects; prompt recognition is essential to ensure patients receive appropriate and timely care to help prevent permanent vision loss. We report a case of anterior uveitis in a post-menopausal woman who presented with visual symptoms after receiving the first dose of zoledronic acid. This case report serves to educate and increase awareness of the risk of uveitis in patients who are given zoledronic acid. This is the first and only reported case of zoledronic acid, when used in the adjuvant setting for the treatment of breast cancer.
Uterine tumor resembling sex-cord tumors of the ovary (UTROSCT): a case of long-term response to pazopanib
Authors: Massa Giacomo , Tessari Anna , Damian Silvia , Duca Matteo , Tamborini Elena , Perrone Federica , Capone Iolanda , Paolini Biagio , Martinetti Antonia , Sottotetti Elisa , de Braud Filippo , Cresta Sara , Pircher Chiara 
Published: December 2022

Abstract
Background
uterine tumor resembling sex-cord tumors of the ovary (UTROSCT) is a rare form of mesenchymal uterine tumor of uncertain malignancy. Sporadic cases of advanced disease are reported, but little is known about its management in the metastatic setting. Pazopanib is a multi-tyrosine kinase inhibitor (TKI), approved for the treatment of advanced renal cell carcinoma and advanced soft tissue sarcomas, which affects several targets, including VEGFR1-2-3, PDGFRα-β and FGFR1-3.
Case Presentation
here we report a case of metastatic UTROSCT with strong and prolonged clinical response to pazopanib.
Conclusions
these findings suggest that this anti-angiogenic approach should be considered in planning future therapeutic strategies for this rare disease. Furthermore, we noted the importance of including patients with rare diseases in clinical trials and investigating molecular pathogenesis.
A new prognostic model for GBM based on coagulation-related genes
Authors: Zhou Min , Deng Yunbo , Fu Ya , Liang RiChu , Wang Bing , Liu Yang , Liao Quan 
Published: December 2022

Abstract
Background: Glioblastoma multiforme (GBM) has the highest aggressiveness and is the most common and lethal types of primary brain tumor. Multiple cancers have been associated with abnormalities in the coagulation system that facilitate tumor invasion and metastasis. In GBM, the prognostic value and underlying mechanism of coagulation-related genes (CRGs) have not been explored.
Methods: RNA sequencing (RNA-seq) and clinical information on GBM were obtained from the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), respectively. Following the identification of differentially expressed CRGs (DECRGs) between BGM and control samples, the survival-related DECRGs were selected by the univariate and multivariable Cox regression analysis to establish a prognostic signature. The prognostic performance and clinical utility of the prognostic signature were assessed by the Kaplan-Meier analysis, receiver operating characteristic (ROC) analysis and the construction of nomogram. The signature genes-related underlying mechanisms were analyzed according to Gene set enrichment analysis (GSEA), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and single-cell analysis. Finally, the difference in immune cell infiltration, stromal score, immune score, and ESTIMATE score were compared between different risk groups.
Results: A five-gene prognostic signature (PLAUR, GP6, C5AR1, SERPINA5, F2RL2) was established for overall survival prediction of BGM patients. The predicted efficiency of the prognostic signature was confirmed in TGGA-BGM dataset and validated in CGGA-BGM dataset, revealing that it could differentiate BGM patients from controls well, and high risk score was accompanied with poor prognosis. Moreover, biological process and signaling pathway analyses showed that signature genes were mainly enriched in the functions of blood coagulation and tumor invasion and metastasis. Moreover, high-risk patients exhibited higher levels of immune cell infiltration, stromal score, immune score, and ESTIMATE score than low-risk patients.
Conclusion:An analysis of coagulation-related prognostic signatures was conducted in this study, as well as how signature genes may affect GBM progress, providing information that might provide new ideas for the development of GBM-related molecular targeted therapies.
Possibility of Incorrect Evaluation of Intraoperative Blood Loss During Open and Laparoscopic Distal Pancreatectomy
Authors: Toya Keisuke , Tomimaru Yoshito , Kobayashi Shogo , Henmi Kazunari , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Noda Takehiro , Takahashi Hidenori , Doki Yuichiro , Eguchi Hidetoshi 
Published: December 2022

Abstract
Purpose
Decreasing intraoperative blood loss is one reported advantage of laparoscopic surgery compared with open surgery. However, several reports indicate that blood loss during laparoscopic surgery may be underestimated. No studies have evaluated this possibility in laparoscopic distal pancreatectomy (LDP). Here we evaluated estimated blood loss (e-BL) compared to actual intraoperative blood loss (i-BL) during distal pancreatectomy (DP).
Methods
This study included 114 patients undergoing DP in our institution during the study period. We examined the relationship between i-BL and e-BL. Based on these results, we further investigated the relationship with LDP.
Results
The laparoscopic approach was used in a significantly higher percentage of patients in e-BL > i-BL group compared to e-BL < i-BL group (55.9% vs. 10.9%, p < 0.0001). Within LDP group (n = 39), e-BL was significantly more than i-BL (388 ± 248 mL vs. 127 ± 160 mL; p < 0.0001). Within open distal pancreatectomy (ODP) group (n = 75), e-BL was significantly less than i-BL (168 ± 324 mL vs. 281 ± 209 mL; p = 0.0017). The e-BL > i-BL trend in LDP group was consistent regardless of the indication for DP. In contrast, the finding of i-BL > e-BL in ODP group was limited to patients with pancreatic cancer.
Conclusion
During LDP, e-BL was significantly more than i-BL. During ODP, e-BL was significantly less than i-BL, only in patients with pancreatic cancer. These results suggested the possibility of i-BL underestimation during LDP, and overestimation during ODP in cases with pancreatic cancer.
Non-self Ćirić α+(θ, ϕ)-proximal contractions with best proximity point
Authors: Alam Khairul Habib , Rohen Yumnam 
Published: December 2022

Abstract
This study aims to provide a new class of Ćirić α+(θ, ϕ)-proximal contraction, a non-self generalized poximal contraction mapping on a non-empty closed subset of any metric space. Also we have proved that such contractions satisfying some conditions must have unique best proximity point if we take the base space as complete. For some particular values of the constants, that we have used to generalize the proximal contraction, we conclude different types of proximal contractions with proof, that all such type of contractions must have unique best proximity point.
Mathematics Subject Classification (2010). Primary 47H10, 54H25; Secondary 41A65, 46B20, 47H05, 47H09.
Nitrate leaching in Argiudoll soil under maize with different doses of fertilizer
Authors: Zamora Martín , Aparicio Virginia , Cerda Artemio , Costa José Luis 
Published: December 2022

Abstract
Nitrogen induced an increase in agriculture production and contributed to the growth of the world population. However, the overuse of nitrogen resulted in the pollution of water resources. The expansion of agriculture in Argentina is a good example of the abuse of nitrogen fertilization, but little is known about the damage induced in water quality. The objectives of this study were to (i) Adjust and validate the LEACH-W model simulations with data observed in the field, (ii) quantify nitrate concentrations in the drainage water, (iii) quantify N leaching from a corn-cropped soil, (iv) calculate a simplified soil-plant N balance. Treatments consisted of 0, 100 and 200 kg N ha-1 applied at planting in a RCBD with 4 replications. Ceramic suction cups, and the LEACH-W model were used to measure and model nitrate leaching, respectively. Nitrate leaching was related to drainage events, and nitrate levels in drainage water surpassed 10 mg L-1 of NO3--N in the fertilized treatments. Nitrate leaching was enhanced by the presence of high residual soil nitrate levels. Losses from the fertilized treatments represented 27 and 17% of the applied N for the 100 and 200 kg N ha rates, respectively. Nitrogen fertilization of maize is a threat of contamination of groundwater in the SE region of Buenos Aires, despite the fact that the doses of nitrogen fertilizer are lower than those used in other parts of the world.
Comprehensive study identifies ZNF692 as a potential immune-related biomarker for colorectal cancer
Authors: Gao Rui Qi , Wang Jing , Dong Dan Hong , Mo Zhen Chang , Yu Pengfei , Li Xiao Hua , Gang Ji 
Published: December 2022

Abstract
Although colorectal cancer (CRC) therapy has evolved significantly in recent years, the prognosis for individuals with advanced cancer is still bad. The molecular mechanisms of this illness and its therapeutic interventions require more research. In recent years, the role of ZNF692 in other tumour development has been heavily investigated, with one study showing that ZNF692 has distinct RNA splicing events within various types of hepatocellular carcinoma. Another study showed that patients with Lung adenocarcinoma with elevated ZNF692 had a poorer prognosis. These results suggest a potential link between ZNF692 and tumourigenesis as well as anti-tumour immunity. This study, which mined and analysed data from the The Cancer Genome Atlas (TCGA) database, discovered that ZNF692 was increased in the tumour cancer cells and tissues of CRC patients, and that high ZNF692 expression was substantially connected with distant metastasis, lymph node metastasis, and tumour stage in CRC patients. Cell lines showed that ZNF692 was abnormally and abundantly expressed in colorectal cancer tumour cells. Overall, the findings point to the possibility of using ZNF692 as a predictive biomarker for CRC.
Invasive Adenoarcinoma Arising in Mucinous Cystic Neoplasm Communicating to Main Pancreatic Duct with Concurrent Pseudocyst: A Report of Very Rare Case
Authors: Kumar Dinesh , Pottakkat Biju , Gnanasekaran Senthil , Raja Kalayarasan 
Published: December 2022

Abstract
Purpose: MCN communicating with pancreatic duct and co-existence of pancreatic pseudocyst with MCN are rare conditions. Malignant transformation in MCN is not uncommon but combination of these rare presentations is very rare and has not been reported previously.
Methods - A Case report of malignant transformation of MCN, which was communicating to MPD with concurrent pseudocyst of pancreas.
Results-Two communicating large cysts in relation of tail of pancreas and lesser sac were diagnosed in a 45-year-old woman who had symptoms of early satiety and postprandial fullness of abdomen with history of recurrent acute pancreatitis.On cross sectional imaging there were two cysts:one multiloculated cyst with internal enhancing septations and solid component, which was communicating to main pancreatic duct and other uniloculated cyst without solid component or sepatations.Preoperative diagnosis of an IPMN with co-existing pseudocyst was made. En-bloc resection of both cysts, distal pancreas-spleen, proximal stomach and left hemidiaphragm with lymphadenectomy was done owing to high risk of malignancy. Final diagnosis on histopathological examination was moderately differentiated grade 2, MCN with invasive adenocarcinoma with coexisting pseudocyst of pancreas.
Conclusion: We are reporting the 1st case of invasive adenocarcinoma arising in MCN, which was communicating to main pancreatic duct with chronic pancreatitis and co-existing pseudocyst of pancreas.This case provides unique opportunity to study spectrum of cystic lesions of pancreas in single case.