bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender-based violence (GBV) coordination in humanitarian and public health emergencies: a scoping review
Authors: Raftery Philomena , Howard Natasha , Palmer Jennifer , Hossain Mazeda 
Published: June 2022

Abstract
Background
Gender-based violence (GBV) is a global health, human rights, and protection issue, which can increase during emergencies. GBV coordination is an essential component of every humanitarian response, ensuring that, from the earliest phases of a crisis, accessible and safe services are available and prevention and mitigation mechanisms are implemented to reduce GBV. We sought to address the limited evidence on GBV coordination, by reviewing literature on GBV coordination in emergencies, identifying facilitators and barriers influencing effectiveness.

Methods
We conducted a scoping review on GBV coordination in emergencies from 1990 to 2020. Studies explicitly discussing GBV coordination in humanitarian, natural disaster and public health emergencies, in low or middle-income countries, were included. Using thematic analysis, we developed a six-topic framework to synthesise evidence on effective GBV coordination and present recommendations for strengthening GBV coordination in emergencies.

Findings
We included 28 of 964 sources identified, covering 30 different emergency settings across 22 countries. Sources spanned emergency settings, with minimal evidence in public health emergencies and none focussed solely on GBV coordination. Several sources suggested that timely establishment of GBV coordination mechanisms, led by dedicated, experienced coordinators, increased funding and strengthened service provision. GBV risk mitigation was compromised by weak commitment across sectors, poor accountability systems, and limited engagement of affected women. Inclusive GBV coordination, involving national and local actors is vital but engagement efforts have been inadequate and localisation funding targets not yet achieved. Implementation of the GBV Information Management System has reinforced coordination, funding allocation and service provision. While specialist GBV services remain insufficient, emergencies can present opportunities for expansion. Sustainability and long-term impact are compromised by over-reliance on international leadership and funding, weak commitment by governments, and limited attention to GBV prevention.

Conclusion
Despite enhanced global commitments to addressing GBV in recent years, it remains consistently under-prioritised and under-resourced. Recommendations to strengthen GBV coordination in emergencies include: funding dedicated GBV coordination positions across all types of emergencies, building the global GBV coordination workforce, expanding inclusion of national actors and investing in GBV risk mitigation and prevention through multiyear funding. The evidence-based framework for effective GBV coordination presented here, can guide further research in diverse emergencies.
Impact of the COVID-19 pandemic on delays in surgical procedures in Germany: a multi-center analysis of an administrative registry of 176,783 patients
Authors: Hunger Richard , König Volker , Stillger Rosi , Mantke René 
Published: June 2022

Abstract
Background
While extensive data are available on the postponement of elective surgical procedures due to the COVID-19 pandemic for Germany, data on the impact on emergency procedures is limited.

Methods
In this retrospective case–control study, anonymized case-related routine data of a Germany-wide voluntary hospital association (CLINOTEL association) of 66 hospitals was analyzed. Operation volumes, in-hospital mortality, and COVID-19 prevalence rates in digestive surgery procedure groups and selected single surgical procedures in the one-year periods before and after the outbreak of the COVID-19 pandemic were analyzed. The analysis was stratified by admitting department (direct admission or transfer to the general surgical department, i.e., primary or secondary surgical patients) and type of admission (elective/emergent).

Results
The total number of primary and secondary surgical patients decreased by 22.7% and 11.7%, respectively. Among primary surgical patients more pronounced reductions were observed in elective (-25.6%) than emergency cases (-18.8%). Most affected procedures were thyroidectomies (-30.2%), operations on the anus (-24.2%), and closure of abdominal hernias (-23.9%; all P’s < 0.001). Declines were also observed in colorectal (-9.0%, P = 0.002), but not in rectal cancer surgery (-3.9%, n.s.). Mortality was slightly increased in primary (1.3 vs. 1.5%, P < 0.001), but not in secondary surgical cases. The one-year prevalence of COVID-19 in general surgical patients was low (0.6%), but a significant driver of mortality (OR = 9.63, P < 0.001).

Conclusions
Compared to the previous year period, the number of patients in general and visceral surgery decreased by 22.7% in the first pandemic year. At the procedure level, a decrease of 14.8% was observed for elective procedures and 6.0% for emergency procedures. COVID-19 infections in general surgical patients are rare (0.6% prevalence), but associated with high mortality (21.8%).

Trial registration
The present study does not meet the ICMJE definition of a clinical trial and was therefore not registered.
Genome analysis and virulence gene expression profile of a multi drug resistant Salmonella enterica serovar Typhimurium ms202
Authors: Mohakud Nirmal Kumar , Panda Rakesh Kumar , Patra Saumya Darshana , Sahu Bikash Ranjan , Ghosh Mrinmoy , Kushwaha Gajraj Singh , Misra Namrata , Suar Mrutyunjay 
Published: June 2022

Abstract
Background
In India, multi-drug resistance in Salmonella enterica serovar Typhimurium poses a significant health threat. Indeed, S. Typhimurium has remained unknown for a large portion of its genome associated with various physiological functions including mechanism of drug resistance and virulence. The whole-genome sequence of a Salmonella strain obtained from feces of a patient with gastroenteritis in Odisha, India, was analyzed for understanding the disease association and underlying virulence mechanisms.

Results
The de novo assembly yielded 17 contigs and showed 99.9% similarity to S. enterica sub sp enterica strain LT2 and S. enteric subsp salamae strain DSM 9220. S. Typhimurium ms202 strain constitutes six known Salmonella pathogenicity islands and nine different phages. The comparative interpretation of pathogenic islands displayed the genes contained in SPI-1 and SPI-2 to be highly conserved. We identified sit ABCD cluster regulatory cascade in SPI-1. Multiple antimicrobial resistance genes were identified that directly implies antibiotic-resistant phenotype. Notably, seven unique genes were identified as "acquired antibiotic resistance". These data suggest that virulence in S. enterica Typhimurium ms202 is associated with SPI-1 and SPI-2. Further, we found several virulent genes encoding SPI regions belonging to type III secretion systems (T3SS) of bacteria were significantly upregulated in ms202 compared to control LT2. Moreover, all these genes were significantly downregulated in S. enterica Typhimurium ms202 as compared to control LT2 on adding Mn2+ exogenously.

Conclusions
Our study raises a vital concern about the potential diffusion of a novel multi-drug resistant S. enterica Typhimurium ms202. It justifies this clinical pathogen to demonstrate a higher degree survival due to higher expression of virulent genes and enhanced ability of metallic ion acquisition.
Effects of small-sided games and running-based high-intensity interval training on body composition and physical fitness in under-19 female soccer players
Authors: Nayıroğlu Sinan , Yılmaz Ali Kerim , Silva Ana Filipa , Silva Rui , Nobari Hadi , Clemente Filipe Manuel 
Published: June 2022

Abstract
Background
The aim of this study was to compare the effects of small-sided games (SSGs) and running-based high-intensity interval training (HIIT) on the body composition and physical fitness of youth female soccer players.

Methods
This study followed a randomized parallel study design. Twenty-four female soccer players (age: 18.63 ± 2.36 years) were randomly allocated to two training groups (SSG, n = 12; and HIIT, n = 12). The training intervention had a duration of eight weeks, consisting of three training sessions per week. Players were assessed twice (pre- and post-intervention) for anthropometrics, vertical (countermovement jumps, CMJ; and drop jumps, DJ) and horizontal jumping (single, triple and crossover hop), sprinting (10- and 30-m), change-of-direction (COD), COD deficit and final velocity at 30–15 Intermittent Fitness Test (VIFT). A covariance analysis (ANCOVA) was used to determine differences between the groups in the effect on post-intervention by controlling for covariates (pre-intervention). The within-group analysis (time) was performed using a paired t-test, while the between-group analysis per assessment moment was performed using an independent t-test.

Results
The between-group analysis with ANCOVA revealed that there are no significant differences between the SSG and HIIT groups in the post-intervention for any outcome (p > 0.05). The within-group analysis revealed significant improvements in both the SSG and HIIT groups in CMJ (p < 0.05), single, triple and crossover hops (p < 0.05), RSI DJ 30-cm and RSI DJ 40-cm (p < 0.05), VIFT (p < 0.05) and COD (p < 0.05).

Conclusions
SSG and HIIT are both effective for improving vertical and horizontal jumping ability, change-of-direction, and aerobic capacity status measured at a progressive and intermittent multistage test in youth soccer players.
Physical property characterization of the Waipapa greywacke: an important geothermal reservoir basement rock in New Zealand
Authors: Melia Aurelio , Faulkner Daniel Roy , McNamara David Daniel 
Published: June 2022

AbstractGreywacke basement rocks in New Zealand host conventional geothermal reservoirs and may supply important hotter and deeper geothermal energy resources in the future. This work combines petrological analyses and physical property measurements of Waipapa greywacke, a basement unit hosting New Zealand geothermal reservoirs, in order to understand better how structurally controlled flow networks develop and channel geothermal fluids within it. Results show intact Waipapa greywacke has high tensile and triaxial compressive strengths, and low intrinsic permeability (~ 10–21 m2). Permeability of intact Waipapa greywacke does not increase significantly during triaxial loading to failure and is accompanied by minimal changes ultrasonic wave velocities. These data taken together suggest that microcrack development during brittle deformation is very limited. Upon failure, the permeability increases by two orders of magnitude and shows similar permeability to tests performed on synthetic, single, mode I fractures in intact Waipapa greywacke. Permeability persists in Waipapa greywacke fractures under confining pressures of at least 150 MPa. It is concluded that Waipapa greywacke rocks will not allow fluid flow through the matrix of the rock and that substantial geothermal fluid flow will only occur through macrofracture networks.
The deeper the better? A thermogeological analysis of medium-deep borehole heat exchangers in low-enthalpy crystalline rocks
Authors: Piipponen Kaiu , Martinkauppi Annu , Korhonen Kimmo , Vallin Sami , Arola Teppo , Bischoff Alan , Leppäharju Nina 
Published: June 2022

AbstractThe energy sector is undergoing a fundamental transformation, with a significant investment in low-carbon technologies to replace fossil-based systems. In densely populated urban areas, deep boreholes offer an alternative over shallow geothermal systems, which demand extensive surface areas to attain large-scale heat production. This paper presents numerical calculations of the thermal energy that can be extracted from the medium-deep borehole heat exchangers in the low-enthalpy geothermal setting at depths ranging from 600 to 3000 m. We applied the thermogeological parameters of three locations across Finland and tested two types of coaxial borehole heat exchangers to understand better the variables that affect heat production in low-permeability crystalline rocks. For each depth, location, and heat collector type, we used a range of fluid flow rates to examine the correlation between thermal energy production and resulting outlet temperature. Our results indicate a trade-off between thermal energy production and outlet fluid temperature depending on the fluid flow rate, and that the vacuum-insulated tubing outperforms a high-density polyethylene pipe in energy and temperature production. In addition, the results suggest that the local thermogeological factors impact heat production. Maximum energy production from a 600-m-deep well achieved 170 MWh/a, increasing to 330 MWh/a from a 1000-m-deep well, 980 MWh/a from a 2-km-deep well, and up to 1880 MWh/a from a 3-km-deep well. We demonstrate that understanding the interplay of the local geology, heat exchanger materials, and fluid circulation rates is necessary to maximize the potential of medium-deep geothermal boreholes as a reliable long-term baseload energy source.
Simulated viewing distance impairs the confidence–accuracy relationship for long, but not moderate distances: support for a model incorporating the role of feature ambiguity
Authors: Davis Sara D. , Peterson Daniel J. 
Published: June 2022

AbstractThere is an increasing need in eyewitness identification research to identify factors that not only influence identification accuracy but may also impact the confidence–accuracy (CA) relationship. One such variable that has a notable impact on memory for faces is viewing distance, with faces encoded from a shorter distance remembered better than faces encoded at longer differences. In four pre-registered experiments, using both laboratory and online samples, we compared faces viewed at a simulated viewing distance at two different levels (medium and far) to faces that were viewed at a very near-simulated distance. Distance was simulated using a Gaussian blur function with higher levels of blur corresponding to greater simulated distance. We found that both medium and far simulated distances impaired memory performance overall relative to no simulated distance, with increased distance resulting in poorer memory. However, only far simulated distances impaired the CA relationship. In a fourth experiment, we found that a pre-test warning did not ameliorate this impairment of the CA relationship for faces viewed at a far simulated distance. These findings suggest that even high-confidence identifications made for faces viewed from long distances should be disregarded, and that estimator variables that impact memory may degrade the CA relationship when memory is reduced to critical levels.
Individual differences in social intelligence and perception of emotion expression of masked and unmasked faces
Authors: Swain Riley H. , O’Hare Aminda J. , Brandley Kamila , Gardner A. Tye 
Published: June 2022

AbstractFacial expressions provide key information for successful social interactions. Recent research finds that accurate perception of emotion expressions decreases when faces are presented with face masks. What is unknown is how individual differences in social intelligence may influence perception of masked emotion expressions. In this study, participants (n = 224) completed an emotion perception task of face stimuli presented with and without face masks and completed two measures of social intelligence: the Reading the Mind in the Eyes Test (RMET) and the Tromsø Social Intelligence Scale (TSIS). Face masks were found to significantly decrease the accurate identification of emotion expressions, impacting the perception of disgust and sad expressions the most. Further, the type of emotion misattributed to facial expressions varied across expressions. Performance on the RMET test did predict perception accuracy, while scores on the TSIS did not. As face masks continue to be common globally, we must be aware that they cause interference with our social interactions and perceptions. Further, some individuals may be more negatively impacted by these effects than others. As such, it is important that we find ways to ensure that we are effectively communicating with one another and have patience when perception mistakes arise.
Migraine and its relation to other risk factors in patients with acute ischemic stroke and acute coronary syndrome
Authors: Hassan Enas M. , Momtaz Osama M. , Hamdy Nermin A. , Yahia Mohamed A. , Afifi Mohamed K. 
Published: June 2022

Abstract
Background
Migraine has been recently studied as a risk factor for ischemic stroke (IS) and a possible link to a broader range of ischemic vascular disorders including angina and myocardial infarction is suggested.

Objectives
to study migraine and its relation to other risk factors in patients with acute IS and acute coronary syndrome (ACS).

Patients and methods
We studied 200 patients, 114 patients had acute IS and 86 patients with ACS, in addition to 850 control participants. All patients were subjected to detailed clinical and laboratory evaluation; including evaluation of traditional risk factors. All stroke patients were subjected to CT scan. Diagnosis of acute coronary syndrome was established clinically by ECG and cardiac specific enzymes. Migraine was diagnosed according to the international headache society and assessment of migraine severity was measured by the Migraine Disability Assessment (MIDAS) questionnaire.

Results
In patients with ischemic stroke, Risk Ratios (RR) of migraine was 3.3 for all migrainous patients, higher for migraine with aura (MA). In the cardiovascular group, it was 2.75 and again higher in MA. A positive correlation between migraine severity and both stroke severity and cardiac affection severity was found though non-significant in the cardiovascular group. There was no significant difference in hospital outcome in migrainous patients in both groups.

Conclusions
Patients with migraine have higher risk than non-migrainous patients for both cerebrovascular and coronary vascular diseases. Risk is stronger in MA in both conditions. Considering migraine in risk stratification of cerebrovascular and cardiovascular diseases is recommended.
Atezolizumab With Neoadjuvant Anti–Human Epidermal Growth Factor Receptor 2 Therapy and Chemotherapy in Human Epidermal Growth Factor Receptor 2–Positive Early Breast Cancer: Primary Results of the Randomized Phase III IMpassion050 Trial
Authors: Huober Jens , Barrios Carlos H. , Niikura Naoki , Jarząb Michał , Chang Yuan-Ching , Huggins-Puhalla Shannon L. , Pedrini José , Zhukova Lyudmila , Graupner Vilma , Eiger Daniel , Henschel Volkmar , Gochitashvili Nino , Lambertini Chiara , Restuccia Eleonora , Zhang Hong ,   the IMpassion050 Trial Investigators
Published: June 2022

PURPOSE Combining standard of care (pertuzumab-trastuzumab [PH], chemotherapy) with cancer immunotherapy may potentiate antitumor immunity, cytotoxic activity, and patient outcomes in high-risk, human epidermal growth factor receptor 2 (HER2)–positive early breast cancer. We report the phase III IMpassion050 primary analysis of neoadjuvant atezolizumab, PH, and chemotherapy in these patients. METHODS Patients with a primary tumor of > 2 cm and histologically confirmed, positive lymph node status (T2-4, N1-3, M0) were randomly assigned 1:1 to atezolizumab/placebo with dose-dense doxorubicin/cyclophosphamide, followed by paclitaxel, and PH. After surgery, patients were to continue atezolizumab/placebo and PH (total: 1 year of HER2-targeted therapy); those with residual disease could switch to ado-trastuzumab emtansine with atezolizumab/placebo. Coprimary efficacy end points were pathologic complete response (pCR; ypT0/is ypN0) rates in intention-to-treat (ITT) and programmed cell death-ligand 1 (PD-L1)–positive populations. RESULTS At clinical cutoff (February 5, 2021), pCR rates in the placebo and atezolizumab groups in the ITT populations were 62.7% (n = 143/228) and 62.4% (n = 141/226), respectively (difference –0.33%; 95% CI, –9.2 to 8.6; P = .9551). The pCR rates in the placebo and atezolizumab groups in patients with PD-L1–positive tumors were 72.5% (n = 79/109) and 64.2% (n = 70/109), respectively (difference –8.26%; 95% CI, –20.6 to 4.0; P = .1846). Grade 3-4 and serious adverse events were more frequent in the atezolizumab versus placebo group. Five grade 5 adverse events occurred (four neoadjuvant, one adjuvant; two assigned to study treatment), all with atezolizumab. Overall, the safety profile was consistent with that of atezolizumab in other combination studies. CONCLUSION Atezolizumab with neoadjuvant dose-dense doxorubicin/cyclophosphamide–paclitaxel and PH for high-risk, HER2-positive early breast cancer did not increase pCR rates versus placebo in the ITT or PD-L1–positive populations. PH and chemotherapy remains standard of care; longer follow-up may help to inform the long-term impact of atezolizumab.
Three-dimensional movement of the beak during seed processing in domestic canaries
Authors: Mielke Maja , Van Wassenbergh Sam 
Published: June 2022

ABSTRACT
Many songbird species rely on seeds as a primary food source and the process of picking up, positioning, cracking, dehusking and swallowing seeds is one of the most sophisticated tasks of the beak. Still, we lack understanding about how granivorous songbirds move their beak during the different phases of seed processing. In this study, we used multi-view high-speed imaging to analyze the 3D movement of the beak in feeding domestic canaries. Our analysis focused on the correlation of the upper and lower beak, the frequency of mandibulation and the direction of mandible movement in 3D space. We show that the correlation of maxilla and mandible movement differs among the phases of seed processing. Furthermore, we found that the beak moves at extremely high frequencies, up to 25 Hz, which resembles previously reported maximal syllable rates in singing canaries. Finally, we report that canaries use specific 3D mandible movements during the different phases of seed processing. Kinematic parameters do not differ between male and female canaries. Our findings provide an important biomechanical basis for better understanding the beak as a functional tool.
Prognostic factors of 112 elderly patients with advanced non-small cell lung cancer
Authors: Ran Fanglan , Liu Qin 
Published: June 2022

Objectives: In this study we retrospectively analyzed the prognostic factors of patients with advanced non-small cell lung cancer (NSCLC).
Methods: Clinical data of 112 patients with advanced NSCLC treated in the tumor center of our hospital from January 2016 to December 2017 were analyzed retrospectively, follow up the survival of patients, the effects of gender, age, tumor stage, pathological type, performance status (PS) score, smoking history and treatment on the survival of elderly patients with advanced NSCLC were analyzed.
Results: The median survival time was 12.0 months, and the median age was 74 years. The 3-year survival rate after confirmation of advanced lung cancer was 6.25%. Kaplan Meier univariate analysis showed that age, PS score, smoking status and treatment correlated with the prognosis(P<0.05). Cox multivariate analysis showed that age >70 years, PS score>2, smoking and no targeted therapy were independent adverse prognostic factors for elderly patients with advanced NSCLC(P<0.05).
Conclusions: Age, PS score, smoking and treatment mode affect the prognosis and survival of elderly patients with advanced NSCLC. Effective treatment should be given according to the principle of evidence-based medicine.
doi: https://doi.org/10.12669/pjms.38.6.5457
How to cite this:Ran F, Liu Q. Prognostic factors of 112 elderly patients with advanced non-small cell lung cancer. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5457
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.