bluuebunny/crossref_metadata_2025_split huggingface dataset:
PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response
Authors: Geng Xinwei , Zhang Chao , Li Miao , Wang Jiaqi , Ji Fang , Feng Hanrong , Xing Meichun , Li Fei , Zhang Lingling , Li Wen , Chen Zhihua , Hickson Ian D. , Shen Huahao , Ying Songmin 
Published: January 2022

AbstractThe Plk1‐interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase DNA bridges in mitosis along with a complex of DNA repair proteins. Previous studies show PICH deficiency‐induced embryonic lethality in mice. However, the function of PICH that is required to suppress embryonic lethality in PICH‐deficient mammals remains to be determined. Previous clinical studies suggest a link between PICH deficiency and the onset of acquired aplastic anemia. Here, using Pich knock‐out (KO) mouse models, the authors provide evidence for a mechanistic link between PICH deficiency and defective hematopoiesis. Fetal livers from Pich‐KO embryos exhibit a significantly elevated number of hematopoietic stem cells (HSCs); however, these HSCs display a higher level of apoptosis and a much‐reduced ability to reconstitute a functional hematopoietic system when transplanted into lethally irradiated recipients. Moreover, these HSCs show an elevated cytoplasmic dsDNA expression and an activation of the cGAS‐STING pathway, resulting in excessive production of type I interferons (IFN). Importantly, deletion of Ifnar1 or cGAS reverses the defective hematopoiesis. The authors conclude that loss of PICH results in defective hematopoiesis via cGAS‐STING‐mediated type I IFN production.
Comment on: The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
Authors: Schymik Hanna S. , Dahlem Charlotte , Barghash Ahmad , Kiemer Alexandra K. 
Published: January 2022

AbstractRecently, first insights into the regulation and the role of the RNA‐binding protein IMP2 in macrophage activation have been published by Wang et al. This study addresses differences in the regulation of IMP2 between the human and murine system. While the expression of IMP2 in anti‐inflammatory macrophages is synchronous in mice and men, IMP2 expression is regulated differently in inflammatory macrophages.
Epitaxy of 2D Materials toward Single Crystals
Authors: Zhang Zhihong , Yang Xiaonan , Liu Kaihui , Wang Rongming 
Published: January 2022

AbstractTwo‐dimensional (2D) materials exhibit unique electronic, optical, magnetic, mechanical, and thermal properties due to their special crystal structure and thus have promising potential in many fields, such as in electronics and optoelectronics. To realize their real applications, especially in integrated devices, the growth of large‐size single crystal is a prerequisite. Up to now, the most feasible way to achieve 2D single crystal growth is the epitaxy: growth of 2D materials of one or more specific orientations with single‐crystal substrate. Only when the 2D domains have the same orientation, they can stitch together seamlessly and single‐crystal 2D films can be obtained. In this view, four different epitaxy modes of 2D materials on various substrates are presented, including van der Waals epitaxy, edge epitaxy, step‐guided epitaxy, and in‐plane epitaxy focusing on the growth of graphene, hexagonal boron nitride (h‐BN), and transition metal dichalcogenide (TMDC). The lattice symmetry relation and the interaction between 2D materials and the substrate are the key factors determining the epitaxy behaviors and thus are systematically discussed. Finally, the opportunities and challenges about the epitaxy of 2D single crystals in the future are summarized.
Abundance and Metabolism Disruptions of Intratumoral Microbiota by Chemical and Physical Actions Unfreeze Tumor Treatment Resistance
Authors: Kong Fanlei , Fang Chao , Zhang Yan , Duan Lixia , Du Dou , Xu Guang , Li Xiaolong , Li Hongyan , Yin Yifei , Xu Huixiong , Zhang Kun 
Published: January 2022

AbstractIntratumoral or intestinal microbiota correlates with tumorigenesis and progression, and microbiota regulation for reinforcing various anti‐tumor approaches is of significant importance, which, however, suffers from no precise regulation method and unclear underlying mechanism. Herein, a microbiome metabolism‐engineered phototherapy strategy is established, wherein Nb2C/Au nanocomposite and the corresponding phototherapy are harnessed to realize “chemical” and “physical” bacterial regulations. Flora analysis and mass spectrometry (MS) and metabonomics combined tests demonstrate that the synergistic microbiota regulations can alter the abundance, diversity of intratumoral microbiome, and disrupt metabolic pathways of microbiome and tumor microenvironment, wherein the differential singling pathways and biosynthetic necessities or metabolites that can affect tumor progression are identified. As well, anti‐TNFα is introduced to unite with bacterial regulation to synergistically mitigate bacterial‐induced inflammation, which, along with the metabolism disruptions of intratumoral microbiota and tumor microenvironment, unfreezes tumor resistance and harvests significantly‐intensified phototherapy‐based anti‐tumor outcomes against 4T1 and CT26 tumors. The clear underlying principles of microbiome‐regulated tumorigenesis and the established microbiome metabolism regulation method provide distinctive insights into tumor therapy, and can be also extended to other gut microbiome‐associated lesions interference.
Stacking Engineered Room Temperature Ferroelectricity in Twisted Germanium Sulfide Nanowires
Authors: Chowdhury Tamaghna , Taneja Chetna , Vasdev Aastha , Ghosh Prasenjit , Sheet Goutam , Kumar G.V. Pavan , Rahman Atikur 
Published: January 2022

AbstractGroup‐IV monochalcogenides have emerged with immense potential to be used as ferroelectric materials in recent times. However, in most of them, ferroelectricity is limited by the presence of inversion symmetry in their natural crystal structure. Here, an experimental observation of ferroelectric order at room temperature by introducing Eshelby twist in Germanium sulfide (GeS) nanowires is reported. The twisted nanowires are synthesized by low‐pressure chemical vapor deposition. The existence of room temperature ferroelectricity in a single nanowire is confirmed by electrical measurements, piezoelectric force microscopy, and second harmonic generation spectroscopy. Density functional theory calculations reveal that the twist in the GeS nanowires breaks the inversion symmetry where the inversion symmetry breaking phonon modes get hardened giving rise to ferroelectricity. These results are expected to be useful in making non‐volatile memory devices, flexible electronics, electronic sensors, and neuromorphic computing.
Explainable artificial intelligence and social science: Further insights for qualitative investigation
Authors: Johs Adam J. , Agosto Denise E. , Weber Rosina O. 
Published: January 2022

AbstractWe present a scoping review of user studies in explainable artificial intelligence (XAI) entailing qualitative investigation. We draw on social science corpora to suggest ways for improving the rigor of studies where XAI researchers use observations, interviews, focus groups, and/or questionnaire tasks to collect qualitative data. We contextualize the presentation of the XAI papers included in our review according to the components of rigor discussed in the qualitative research literature: (a) underlying theories or frameworks; (b) methodological approaches; (c) data collection methods; and (d) data analysis processes. The results of our review dovetail with calls made by others in the XAI community advocating for collaboration with experts from social disciplines toward bolstering rigor and effectiveness in user studies.
Picking on Carbonate: Kinetic Selectivity in the Encapsulation of Anions
Authors: Xie Han , Gunawardana Vageesha W. Liyana , Finnegan Tyler J. , Xie William , Badjić Jovica D. 
Published: January 2022

AbstractSupramolecular hosts bind to inorganic anions at a fast rate and select them in proportion with thermodynamic stability of the corresponding [anion⊂host] complexes, forming in a reversible manner. In this study, we describe the action of hexapodal capsule1and its remarkable ability to select anions based on a large span of rates by which they enter this host. The thermodynamic affinity of1toward eighteen anions extends over eight orders of magnitude (0<Ka<108 M−1;1H NMR spectroscopy). The capsule would retain CO32−(Ka=107 M−1) for hours in the presence of eleven competing anions, including stronger binding SO42−, HAsO42−and HPO42−(Ka=107–108 M−1). The observed selection resulted from1possessing narrow apertures (ca. 3×6 Å) comparable in size to anions (d=3.5–7.1 Å) slowing down the encapsulation to last from seconds to days. The unorthodox mode of action of1sets the stage for creating hosts that pick anions by their ability to access the host.
Three‐Dimensional Crystalline Covalent Triazine Frameworks via a Polycondensation Approach
Authors: Sun Ruixue , Wang Xiaoyan , Wang Xuepeng , Tan Bien 
Published: January 2022

AbstractThe growth of crystalline covalent triazine frameworks (CTFs) is still considered as a great challenge due to the less reversible covalent bonds of triazine linkages. The research studies of crystalline CTFs to date have been limited to two‐dimensional (2D) structures, and the three‐dimensional (3D) crystalline CTFs have never been reported before. Herein we report the design and synthesis of two 3D crystalline CTFs, termed 3D CTF‐TPM and 3D CTF‐TPA through a reversible/irreversible polycondensation approach. The targeted 3D CTFs adopt ctn topology, and show moderate crystallinity, relatively large surface area (ca. 2000 m2 g−1), and high CO2 uptake capacity (23.61 wt.%). Moreover, these 3D CTFs exhibit ultrastability in the presence of boiling water, strong acid (1 M HCl) and strong base (1 M NaOH). This contribution represents the first report of 3D crystalline CTFs, which not only extends their structural diversity but also offers a synthetic strategy and structural basis for expanding practical applications of CTF materials.
Unprecedented and Readily Tunable Photoluminescence from Aliphatic Quaternary Ammonium Salts**
Authors: Tang Saixing , Zhao Zihao , Chen Jinquan , Yang Tianjia , Wang Yunzhong , Chen Xiaohong , Lv Meng , Yuan Wang Zhang 
Published: January 2022

AbstractCompounds bearing aliphatic amines can be emissive under appropriate conditions. However, their ionized counterparts, namely, quaternary ammonium salts (QASs), which are widely used as phase‐transfer catalysts, ionic liquids, disinfectants, and surfactants, are known as luminescence quenchers and considered nonemissive. Herein, unprecedented intrinsic fluorescence/phosphorescence dual emissions from various QASs are reported, which can be finely regulated by changing the excitation wavelength, alkyl chain length, counterion, and mechanical stimuli. The bright photoluminescence along with distinct afterglow and tunable multicolor emissions enables the application of QAS solids in advanced multimode anticounterfeiting. This finding refreshes the understanding of QASs and may inspire emerging applications based on the utilization of the intrinsic luminescences of QASs. Furthermore, it opens opportunities for the investigation of QAS‐related processes and functions via a photophysical approach and affords strong implications for the fabrication of novel nonconventional luminophores.
Synthesis, characterization, superoxide dismutase, and antimicrobial activities of Co (II) complexes with Schiff base ligand and their hybrid proteins
Authors: Mo Dan , Song Xun , Wu Jiri , Jaiswal Yogini , Guan Yifu , Zhang Yuzhen , Shen Yunjun , Bian Hedong 
Published: January 2022

AbstractMetal complexes have been reported to possess excellent free radical scavenging and antimicrobial properties. In the present study, seven linear trinuclear complexes were synthesized based on bis Schiff base ligand and complexes 1, 3–7 are reported for the first time. Their structure was characterized by IR spectroscopy and single crystal diffraction. BSA was used as carrier to hybridize the synthesized complexes to construct hybrid proteins. The interaction between metal complex and BSA was studied by UV–Vis spectrophotometry and fluorescence spectroscopy. Static quenching was the main mechanism identified for the interaction between metal complex and BSA. In the superoxide dismutase (SOD) activity test, IC50 values of complexes and hybrid proteins range between 2.89 and 26.53 μM, with hybrid proteins demonstrating a stronger activity than the complexes. Among all the complexes studied, complex 5 exhibited the strongest inhibition against Candida albicans (MIC 12.5 μg ml−1) and Cryptococcus neoformans (MIC 6.5 μg ml−1).
Highly active and thermostable camphyl α‐diimine–nickel(II) catalysts for ethylene polymerization: Effects of N‐aryl substituting groups on catalytic properties and branching structures of polyethylene
Authors: Zhang Qiuyue , Liu Ming , Ma Yanping , Ye Zhibin , Liang Tongling , Sun Wen‐Hua 
Published: January 2022

A group of nickel bromide complexes containing the rigid bidentate bis(arylimino)camphane ligands (Ar‐BIC) with different N‐aryl substituents, [ArN═C(camphyl)C(camphyl)═NAr]NiBr2 (Aryl = 2,6‐Me2C6H3 [Ni1], 2,4‐Me2C6H3 [Ni2], 2,4,6‐Me3C6H2 [Ni3], 2,6‐Me2‐4‐{(C6H4F)2CH}‐C6H2 [Ni4], 2,4‐Me2‐6‐{(C6H4F)2CH}‐C6H2 [Ni5, with the corresponding ligand as L5], and 2‐Me‐4,6‐{(C6H4F)2CH}2‐C6H2 [Ni6]), has been synthesized and characterized. The molecular structures of L5, Ni1, Ni3, Ni4, and Ni6 were elucidated with single‐crystal X‐ray diffraction. The nickel centers displayed a four‐coordinate geometry that can be best described as a distorted tetrahedral geometry. Upon treatment with either MMAO or Me2AlCl, Ni1–Ni6 showed moderate to high activities for ethylene polymerization, producing polyethylenes (PEs) with low to high molecular weights (0.02–23.7 × 105 g mol−1) and low polydispersity indices (PDI: 1.6–2.6). In comparison with reference nickel precatalysts ligated by bis(arylimino)acenaphthene (Ar‐BIAN) and bis(arylimino)butane (Ar‐BIB), the title complexes displayed much better thermal stability and higher catalytic activities (up to 11.2 × 106 g PE (mol Ni)−1 h−1 at 70°C), delivering polyethylenes with higher molecular weights. All the resultant polyethylenes are moderately to highly branched with the branching content and type of branching strongly affected by the type of N‐aryl substituting groups. Notably, the polymers produced with ortho‐hydrogen Ni2/Me2AlCl possessed the highest branching density and unique terminal vinyl (CH═CH2) and internal vinylene (CH═CH) structure. On the other hand, ortho‐di(p‐fluorophenyl)methyl‐containing Ni5 and Ni6 just gave 30 and 19 branches per 1000 Cs due to the reduced chain walking capability as a result of the bulkier substituting groups.
Output tracking of stochastic high‐order nonlinear systems perturbed by second‐order moment process
Authors: Wang Ruitao , Li Wuquan 
Published: January 2022

AbstractIn this paper, we study the output tracking problem of stochastic high‐order nonlinear systems perturbed by second‐order moment process. Unlike the existing results that focused on systems with wiener process, we consider a more practical noise, the second‐order moment process in this paper. We propose a new design method where piecewise functions are suitably constructed to deal with coupling terms between nonlinear functions and the noise. The designed controller ensures that the tracking error can be tuned arbitrarily small, the closed‐loop system has a unique solution, and all states are bounded in probability. Finally, a simulation example is given to illustrate the effectiveness of our control scheme.
Drivers of employees' proactiveness for sustainability embeddedness: Examining situation‐related antecedents of information exchange
Authors: Todaro Niccolò Maria , Testa Francesco , Gusmerotti Natalia Marzia 
Published: January 2022

AbstractEmbedding sustainability in day‐to‐day operations necessitates employees' proactiveness beyond compliance with standardised management practices. Exchanging information on safety and environmental issues is acknowledged as a component of workers' proactive behaviours for sustainability embeddedness, which is hardly promoted by codified procedures. Accordingly, identifying leverages to stimulate information exchange is a primary objective for academics and practitioners. The study investigates drivers of information exchange on safety and environmental near misses by examining five situation‐related antecedents: rewards/reinforcements, organisational boundaries, social proactiveness, stakeholder salience and connectedness. The study relies on a mixed method approach, by combining social network analysis and a questionnaire survey conducted among four large Italian companies. The findings partially support the hypothesis of the study, highlighting rewards/reinforcements and connectedness as relevant antecedents of information exchange, while organisational boundaries only partially relate with information exchange. Surprisingly, stakeholder salience and social proactiveness do not emerge as significant drivers of information exchange. The study contributes to the debate on extra‐role pro‐sustainability behaviours and provides implications for managerial practice.
Ru and Fe Alloying on a Two‐Dimensional MXene Support for Enhanced Electrochemical Synthesis of Ammonia
Authors: Liu Anmin , Liang Xingyou , Gao Mengfan , Ren Xuefeng , Gao Liguo , Yang Yanan , Zhu Haiding , Li Guangxin , Ma Tingli 
Published: January 2022

AbstractCompared with the energy‐intensive Haber‐Bosch process, the electrocatalytic nitrogen reduction reaction (NRR) is a promising approach for sustainable ammonia production. However, the design and development of electrocatalysts with high activity and selectivity is currently a major challenge. In this work, we successfully constructed RuFe bimetallic nanoparticles on a two‐dimensional MXene support (RuFe@MXene) through a simple liquid phase reduction method. Benefiting from the rich surface chemistry and high electronic conductivity of MXene, as well as the synergistic effect between RuFe bimetals, the composite can efficiently synthesize ammonia under environmental conditions. Specifically, the NH3 yield and Faraday efficiency of the prepared Ru0.3Fe0.7@MXene composite catalyst reaches 40.79 μg h−1 cm−2 and 15.25 % at −0.4 V vs. RHE in 0.1 M KOH, which are significantly higher than that of the previously reported Ru@MXene. Moreover, the Ru0.3Fe0.7@MXene catalyst also exhibits outstanding electrochemical stability. The density of state (DOS) and the partial density of state (PDOS) of MXene, Fe@MXene, Ru@MXene, and RuFe@MXene were calculated by DFT to explore the synergistic effect of RuFe on the nitrogen reduction performance of MXene‐based catalysts. This work guides the design of high‐performance NRR electrocatalysts in the future.
How to Model the Cathode Area in Lithium‐Sulfur Batteries?
Authors: Abdulkadiroglu Busra , Bektas Hilal , Eroglu Damla 
Published: January 2022

AbstractIn this study, a 1‐D electrochemical model was employed to predict the effect of key design parameters, such as carbon‐to‐sulfur (C/S) ratio, electrolyte‐to‐sulfur (E/S) ratio, and sulfur loading on the discharge capacity and voltage profile of a lithium‐sulfur (Li−S) battery. Herein, a novel definition for the electrochemically active area is proposed based on the weight fraction of carbon and a reference porosity in the cathode. The experimental trends of the discharge behavior of a Li−S cell were captured by the model regarding the change in key design parameters. Results were given in comparison with the predictions of two other models that use different active area definitions, and it was concluded that a sensible representation of the electrochemically active area is critical for modeling the effect of cell design on the discharge performance of a Li−S battery.
Synthesis and Electrochemistry of Free‐Base Porphyrins Bearing Trifluoromethyl meso‐Substituents
Authors: Al Shehimy Shaymaa , Frath Denis , Dumont Elise , Chevallier Floris , Bucher Christophe 
Published: January 2022

AbstractCF3‐substituted porphyrins have attracted increasing interest over the past decade. However, the number of examples reported in the literature remains quite limited and much remains to be done to understand the properties and reactivity of these molecules. We are now reporting on the synthesis of a series of free base porphyrins incorporating one, two and three CF3 substituents, including the 5,10,15‐tris(CF3) substituted porphyrin which has never been described before. We have also carried out detailed electrochemical and spectroscopic analyses aiming at assessing the electron‐withdrawing properties of the CF3 substituents compared to the widely used C6F5. Our studies led us to propose an interpretation of the quite unusual electrochemical signature of these molecules featuring three successive one‐electron reduction waves.
Two‐step thermal decomposition mechanism of phosphogypsum for resource utilization
Authors: Qian Wenmin , Ning Ping , Zhu Haodong , Song Xin 
Published: January 2022

AbstractIn this work, the reduction–oxidation two‐step method was used for investigating the resource utilization of phosphogypsum. The influences of different decomposition conditions were investigated, including the reducing process and oxidizing process. The reductive organic sulphide in lignite reacted with CaSO4 and improved the CaSO4 decomposition rate. High Fe2(SO4)3 content and anhydrous air flow rate promoted the formation of Fe–Ca–Ox, decreasing the CaSO4 decomposition rate. H2O derived from CH4 reacted with lignite to consume the solid reducing agent. In the reducing process, CaSO4 reacted with CH4 and lignite to form CO, CO2, H2O, and CaS. In the oxidizing process, CaS was mainly oxidized into CaO, SO2, and element S. Through a two‐step decomposition process (reduction with CH4 and oxidation with air), the decomposition temperature of phosphogypsum decreases and the decomposition efficiency is improved. Meanwhile, the residual lignite was oxidized into CO and CO2. Therefore, it is meaningful and valuable.
Precipitation of lithium phosphate from lithium solution by using sodium phosphate
Authors: Shin Dong Ju , Joo Sung‐Ho , Lee Dongseok , Shin Shun Myung 
Published: January 2022

AbstractLithium was studied to precipitate into Li3PO4 by adding Na3PO4 under various experimental conditions such as initial lithium concentration of the solution, initial pH of the solution, temperature, and the mol equivalent ratio of Na3PO4. The precipitation mechanism of Li3PO4 was investigated with the change of pH value of the solution over time. The precipitation efficiency of Li3PO4 was 95.4% in the condition of the mol equivalent ratio of Na3PO4 of 1, initial Li concentration of 7 g/L, initial pH of 9.5, and at 90°C. When Na3PO4 was added three times, divided in the mol equivalent ratio of 1 via the hydrolysis reaction of PO43−, which inhibits the Li3PO4 precipitation reaction, an excellent precipitation efficiency of 98.4% was obtained. Co‐precipitated Na2HPO4 with Li3PO4 was washed by distilled water in the condition of solid/liquid ratio of 10% and at 90°C. The purity of the final Li3PO4 product was found to be 99.1%.