bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing Nursing Science and Practice in Unison
Authors: Kennedy Patrick , Cameron Patricia , Munyan Kristen 
Published: May 2022

PurposeThe purpose of this article is to explore the strengths of collaborative Doctor of Nursing Practice (DNP) and the Doctor of Philosophy (PhD) research drawing on the assets of the complementary skill sets, explore examples of current DNP/PhD collaborations, and provide a model for building these partnerships.DesignA DNP and PhD collaboration was examined through case analysis. Courtney and Neiheisel’s model was used as a framework to examine the development, implementation, and evaluation of DNP and PhD collaboration.MethodsThe DNP/PhD collaboration phases were examined using Tuckman’s five-stage model for high-performance team development.ConclusionDoctoral-prepared nurses must understand each other’s background and education to facilitate combined contributions. This exemplar demonstrates the effectiveness of a synergistic relationship in a DNP/PhD collaboration.Clinical RelevanceA collaborative partnership between DNP and PhD nurses creates a practice environment that helps discover, integrate, apply knowledge, and communicate and disseminate it. This same collaborative effort between the two roles has been shown to reduce practice gaps while ultimately improving patient outcomes.
Recognition of emotions in the elderly through facial expressions: Emotions biofeedback as a therapy support tool
Authors: Torcate Arianne Sarmento , de Santana Maíra Araújo , Gomes Juliana Carneiro , Nunes Ingrid Bruno , Fonseca Flávio Secco , Moreno Giselle Magalhães Machado , Santos Wellington Pinheiro dos 
Published: May 2022

Abstract
Purpose: Data provided by the World Health Organization indicate that the number of people aged 60 years or more in the world population is gradually increasing. Moreover, projections clarify that in 2030 there will be 1.4 billion elderly people and 2.1 billion in 2050. Along with the natural aging process of any human being, changes in perception and cognition can cause damage that contributes to elderly people having difficulties both to recognize and to express emotions through the face. Few researches in the literature address the recognition of emotions in elderly, whether they are affected by dementia processes or not. In consequence of this, few databases are made available for carrying out work and experiments. Not being able to express and recognize emotions through the face can contribute to the elderly having difficulties in communicating important messages, which may even compromise their physical integrity.Methods: Therefore, this work aims to develop an application for Emotion Recognition in the elderly through Facial Expressions. For this, we first used Haar cascade Frontal Face for face detection and implemented a Convolutional Neural Network to classify emotions, using FER2013 database for training, validation and testing. In a second part of the methodology, in order to assess the performance of the algorithm in this context, we applied the developed model to recognize emotions in static images of elderly people.Results: As a result, the accuracy achieved by the developed model was 0.6375. From the images tested, for 52.63% of them the model was able to detect the face and identify some emotion. On the other hand, in 47.37% of the images, the model had difficulty both in detecting the face and in identifying emotions.Conclusion: Finally, the findings and discussions exposed in this work are promising, we also found and shared limitations and related them to our goals for future works. The possibility of developing intelligent systems that support emotion recognition in elderly population emerges as a valuable tool, representing an alternative to promote not only quality of life for the elderly themselves, but also for the entire support network around them.
Improving Healthcare Transition of Young Adults with Chronic Diseases at The Ottawa Hospital: a cross-sectional study assessing the patient’s perspective on current practices
Authors: Fulcher Jill , Malcolm Janine , Keely Erin , Murthy Sanjay , McCurdy Jeffrey , Chin Melanie , Aaron Shawn D. , Gaudet Ena , Cabral Antonio , McConville Eilish , Mack Johnathan , Toupin Melissa , Ramsay Timothy , Bredeson Christopher , Wells Philip 
Published: May 2022

Abstract
Background: Transfer of young adults (YAs) with chronic diseases from pediatric- to adult hospital-based care is a major life event for this vulnerable group of patients. Inadequate preparation of the YAs and poorly planned transition of care are associated with subsequent treatment non-adherence, discontinuity of care and poor long-term outcomes. A formalized structured process for HCT has been demonstrated to improve patient experience and optimize subsequent engagement with adult healthcare and is now recommended as standard of care. Implementation of this approach is however suboptimal at a global level and practices vary within institutes and between specialties. We recognized this issue at the Ottawa Hospital (TOH) and sought to explore the impact of differences in approaches to HCT from the YA’s perspective. We assessed and compared patient experience of HCT in specialties with and without a structured HCT program with the aim of gaining insight into gaps in care to facilitate reforming current practices and optimizing care. Methods: YAs aged 18 to 25 years (n=175) who had transitioned into five adult specialties at TOH volunteered for this study. A self-care assessment survey and two feedback surveys were customized from the Got TransitionTM HCT measurement resources. Responses of those YAs attending clinics with (n=93) and without (n=82) a structured HCT program were assessed and compared.Results: YAs who transitioned into clinics with structured HCT reported better medical knowledge and practical skills for independent use of the healthcare system compared to YAs who attended clinics without a formal HCT process. This group reported a greater level of involvement in preparation for HCT by their pediatric health-care providers and better education and provision of practical information by their adult healthcare team compared to the YAs attending clinics without a formal HCT process. Conclusions: Results demonstrate superior health knowledge and healthcare usage skills in YAs attending clinics with structured HCT programs and support the benefit of establishing a structured approach to HCT across all specialties caring for transitioned YAs at TOH. By identifying strengths and gaps in current practices, this study has provided a basis to drive institutional reform to improve quality of care for this vulnerable patient population.
Association of Lung Function With Benzene, Toluene and Xylenes (Btx) in End-exhaled Air in Gas Station Attendants
Authors: Warnakulasuriya Tania , Medagoda Kushan , Amarasiri Lakmali , Wadasinghe Dilesha , Kottahachchi Dulani , Luke Dunya , Ariyawansa Janaki , Rathnayake Prasanna , Dissanayake Tharuka , Fernando Sudeera , Werdt Laurie , Ediriweera Dileepa , Wickramasinghe Rajitha , Silva Deepthi C , Devanarayana Niranga Manjuri , Scheepers Paul T.J. 
Published: May 2022

Abstract
Background - Gas station attendants are exposed to benzene, toluene and xylenes (BTX) from fuels. The aim was to study the association between this exposure and spirometry parameters in gas station attendants and office workers as controls.Method – In 44 male gas station attendants and 38 office workers in the Gampaha district of Sri Lanka spirometry was performed according to the guidelines of the American Thoracic Society (ATS). Pre- and post-shift end-exhaled air samples were collected from a subset of both study groups and analysed for BTX by gas chromatography-mass spectrometry.Results – Among gas station attendants (n = 20) median pre-/post-shift exhaled air concentrations (ng/L) were: benzene 11.23/21.05; toluene 10.39/22.19; m/p-xylene 1.62/2.45; o-xylene 1.01/1.45. For controls (n = 11) these values were (ng/L): 9.47/12.04, 3.13/4.00, 1.52/1.25 and 0.50/0.48, respectively. The peak expiratory flow rate (PEFR) and %-predicted PEFR were significantly lower among gas station attendants compared to controls (p < 0.012). The % predicted FVC and FEV1/FVC ratio were not different but in gas station attendants benzene in post-shift samples was associated with %-predicted FVC (Spearman’s correlation coefficient of -0.469, p = 0.037). In addition, the %-predicted FVC was lower in gas station attendants working ≥ 5 years compared to those who worked < 5 years. In controls a distinct pattern was observed, indicating a moderate to strong association of post-shift toluene and m/p-xylenes with all lung function parameter but not benzene. These results were adjusted for smoking. Air pollutants other than BTX may have contributed to explaining our findings.Conclusion – Overall, we did not observe changes to the lung function of clinical relevance that can be explained by occupational exposure to BTX. In gas station attendants we observed obstructive responses in spirometry that were most pronounced for the level of work-related benzene exposure and also associated with duration of employment. In office workers (as controls) a distinct pattern of associations with BTX exposure was observed, indicating a moderate to strong association of the exposure level of toluene and m/p-xylenes with all lung function parameters.
Does the fear of covid-19 transmission affect hospital attendance in Cameroon?
Authors: Nanfosso Roger Tsafack , Tadadjeu Sosson 
Published: May 2022

Abstract
Utilization of health services during COVID-19 is an important policy for improving health outcomes. However, demand-side barriers to health care are as important as supply-side factors in deterring patients from seeking care during this health crisis. This paper takes a fresh look and contributes to the literature by focuses on a demand-side factor, the fear of Covid-19 infection. We use data from the Coronavirus Impact Assessment Survey conducted by the National Institute of Statistics and compiled data from the World Health Organization’s Covid-19 newsletter in Cameroon. These data show that 61.2% of respondents were using hospitals less during the health crisis. The results of the Probit regressions show that concern about the Covid-19 pandemic reduces the likelihood of attending hospitals. However, this result is heterogeneous by sector of activity and the place of residence of the respondents. The reduction of outings and the suspension of jobs also explain the low hospital attendance during this crisis. Based on these results, we encourage the massive sensitization of communities in using formal health care in strict compliance with the measures to fight the pandemic.
MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
Authors: Zhao Jun-Zhang , Wang Wei , Liu Tao , Zhang Lei , Lin De-Zheng , Yao Jia-Yin , Peng Xiang , Jin Gang , Ma Tian-Tian , Gao Jin-Bo , Huang Fang , Nie Jun , Lv Qing 
Published: May 2022

Abstract
Background: Metabolic reprogramming is a hallmark of cancer, alteration of nucleotide metabolism of hepatocellular carcinoma (HCC) is not well-understood. MYBL2 regulates cell cycle progression and hepatocarcinogenesis, its role in metabolic regulation remains elusive. Patients and methods: Copy number, mRNA and protein level of MYBL2 and IMPDH1 were analyzed in HCC, and correlated with patient survival. Chromatin Immunoprecipitation sequence (Chip-seq) and Chromatin Immunoprecipitation quantitative polymerase chain reaction (ChIP-qPCR) were used to explore the relationship between MYBL2 and IMPDH1. Metabolomics were used to analyze how MYBL2 affected purine metabolism. The regulating effect of MYBL2 in HCC was further validated in vivo using xenograft models. Results: The Results showed that copy-number alterations of MYBL2 occur in about 10% of human HCC. Expression of MYBL2, IMPDH1, or combination of both were significantly upregulated and associated with poor prognosis in HCC. Correlation, ChIP-seq and ChIP-qPCR analysis revealed that MYBL2 activates transcription of IMPDH1, while knock-out of MYBL2 retarded IMPDH1 expression and inhibited proliferation of HCC cells. Metabolomic analysis post knocking-out of MYBL2 demonstrated that it was essential in de novo purine synthesis, especially guanine nucleotides. In vivo analysis using xenograft tumors also revealed MYBL2 regulated purine synthesis by regulating IMPDH1, and thus, influencing tumor progression. Conclusion: MYBL2 is a key regulator of purine synthesis and promotes HCC progression by transcriptionally activating IMPDH1, it could be a potential candidate for targeted therapy for HCC.
Prevention and screening during the COVID-19 pandemic: Qualitative findings from the BETTER WISE project
Authors: Sopcak Nicolette , Wong Melanie , Fernandes Carolina , Ofosu Daniel , Khalil Ielaf , Manca Donna 
Published: May 2022

Abstract
Background: The COVID-19 pandemic challenged healthcare systems worldwide and disrupted primary care, particularly prevention, screening, and lifestyle counselling. BETTER WISE is a comprehensive and structured approach that proactively addresses cancer and chronic disease prevention and screening (CCDPS), including cancer survivorship and screening for poverty and lifestyle risks for patients aged 40 to 65. Patients from 13 primary care clinics (urban, rural, and remote) in Alberta, Ontario, and Newfoundland & Labrador, Canada were invited for a 1-hour visit with a prevention practitioner (PP), a member of the primary care team with specialized training in CCDPS to provide patients an overview of eligible screening and assist with lifestyle counselling. This qualitative sub-study describes how the COVID-19 pandemic impacted BETTER WISE in a constantly changing medical landscape.Methods: We conducted 17 focus groups and 48 key informant interviews with a total of 132 primary care providers (PPs, physicians, allied health professionals, and clinic staff) over three different data points to better understand their perspectives on the BETTER WISE project. We also received 585 patient feedback forms of the 1,005 patients who agreed to participate in the study. We also collected field notes and memos and employed thematic analysis using a constant comparative method focused on the impact of the pandemic on BETTER WISE.Results: We identified four themes related to how the COVID-19 pandemic impacted the BETTER WISE study: 1) Switch of in-person visits to visits over the phone; 2) Lack of access to preventive care and delays of screening tests; 3) Changes in primary care providers’ availability and priorities; 4) Impact of the pandemic on patients’ and primary care providers’ mental health.Conclusions: The COVID-19 pandemic had and, at the time of writing, continues to have an impact on primary care, particularly on prevention, screening, and lifestyle counselling. Despite structural and procedural challenges throughout different waves of the pandemic, the primary care clinics participating in BETTER WISE were able to complete the study. Our results underscore the importance of the role of primary care providers in adapting to changing circumstances and support of patients in these challenging times.Trial registration: This qualitative study is a sub-component of the BETTER WISE pragmatic, cRCT, trial registration ISRCTN21333761 (date of registration 19/12/2016)
Size-Dependent Adsorption Performance of ZnO Nanoclusters for Drug Delivery Applications
Authors: Kurban Mustafa , Muz İskender 
Published: May 2022

Abstract
We have investigated the size-dependent adsorption performance of ZnO nanoclusters (NCs) as drug delivery carriers for the first time. Our results show that the adsorption energy of the favipiravir drug on the ZnO NCs is predicted in the range of -26.69 kcal/mol and − 34.27 kcal/mol. The adsorption energy (-34.27 kcal/mol) between (ZnO)18 NC and the favipiravir is energetically desirable and more favorable than the other interactions. The size of ZnO NCs and the position of the favipiravir on the ZnO NCs cause a decrease in the energy gap, which makes the charge-transfer process easier. The bonds between O – Zn, N – Zn and F – Zn atoms exhibit dual covalent and ionic natures. The non-covalent interaction analysis shows that the strongest H-bonds are observed near NH2 within the favipiravir molecule. Finally, the acquired results show that the interaction of ZnO NCs with the favipiravir anticancer drug can have the potential as drug delivery carriers.
“When I am breathless now, I don’t have the fear that’s linked to it.” A case series on the potential of EMDR to break the dyspnea-anxiety cycle in COPD
Authors: Mooren Kris , Smit Kirsten , Engels Yvonne , Janssen Daisy , Godschalx Judith 
Published: May 2022

Abstract
BackgroundExpectations can enhance the intensity and the neural processing of breathlessness. Previous breathlessness episodes may have a psychotraumatic effect and may influence perception of subsequent episodes. In post-traumatic stress disorder, eye movement desensitization and reprocessing (EMDR) is the therapy of choice. Aims and objectivesWe explored the hypothesis that EMDR in patients with chronic obstructive pulmonary disease (COPD) and previous severe breathlessness episodes improves breathlessness mastery by decreasing the anxiety component. MethodsSince there is no previous research on this subject, we undertook a qualitative case series to explore it. We included four patients with COPD GOLD 4/D and refractory breathlessness who wished to undergo EMDR for traumatic breathlessness episodes. Amongst others, we used the Chronic Respiratory Disease Questionnaire (CRQ) before and after EMDR, and semi-structured, face-to-face, in-depth interviews.ResultsAll patients had between 3 and 5 EMDR sessions. On CRQ, subset mastery, 3 patients had a large improvement and 1 patient a moderate improvement. On subset emotional functioning, 3 patients showed a large clinically relevant improvement and 1 patient showed no change. All patients made a distinction between ‘regular’ breathlessness and breathlessness intertwined with anxiety. They all stated that the anxiety component of their breathlessness diminished or disappeared. When asked whether they would recommend EMDR for other COPD patients, all four subjects answered positively.ConclusionsThere is ground for a randomized controlled clinical trial to test the effect of EMDR on breathlessness mastery in a subset of COPD patients with previous severe breathlessness episodes and high levels of anxiety.
Blade-running: An efficient sanitary behavior against summit disease in ants
Authors: Erős Katalin , Csata Enikő , Rákosy László , Markó Bálint 
Published: May 2022

Abstract
Social systems are attractive targets for parasites. Once infiltrated they could manipulate the host to contribute to their further dispersal. A wide array of parasites causes summit disease driving their host up on a grass blade from where propagules are then dispersed. In ants, previous observations suggested the existence of a social prophylactic strategy that could help reduce the pathogen’s dispersal success through early corpse disposal in the case of summit causing pathogenic Pandora fungus. We experimentally tested the efficiency of such prophylactic mechanisms in a large nest complex using fresh ant corpses and dummies fixed to grass blades. Indeed, ants discovered and disposed of corpses very efficiently, primarily of those close to the nest margin, while dummies were mostly neglected. We argue that this behavior is not necessarily specific, but rather part of a general set of behaviors that could be of use to fight other pathogens as well that cause summit disease.
A parametric approach to estimate streamflow quantiles using annual flow–duration curves
Authors: Asikoglu Omer Levend , Narin Tugce 
Published: May 2022

Abstract
The flow–duration curve (FDC) is a significant instrument used in solving many hydrological and environmental problems such as evaluating water quality, examining water supply and use for hydroelectric generation and irrigation, and investigating sedimentation and low flows. However, the insufficiency of flow data allows FDCs to be used only for gauged basins or gauged locations in a basin. Therefore, obtaining regional relationships that provide effective estimates about a region, by using the records of existing stations in the region, becomes necessary. This paper illustrates a simple parametric approach, where droughts are characterized by using the lower part of the annual flow–duration curve. The paper uses the actual instantaneous flow data of 30 basins in Western Anatolia and 21 basins in Southwestern Anatolia, Turkey to offer a new perspective for the estimation of streamflow quantiles using Areal Scale Factors (ASFs), which efficiently represent the relationship between flow quantile and basin area.
Salvianolic acid A improves chronic cerebral ischemia through TLR4/MAPKs/AP-1 signaling pathway
Authors: Bai Fei , Yin Sheng , Xu Yue , Wang Jian , Hu Qing-Qing , Sun Ren-Kuan , Wang Jin-Hui , Yang Bao-Feng , Li Chun-li 
Published: May 2022

Abstract
Chronic cerebral hypoperfusion (CCH) is a clinical syndrome. Long-term chronic cerebral low perfusion will lead to insufficient blood supply to the brain, this leads to a pathological cascade. Salvianolic acid A (SAA) is a water-soluble phenolic acid contained in Salvia miltiorrhiza Bge., which has regulated effect on cardiovascular and cerebrovascular diseases. We established a chronic bilateral common carotid artery occlusion (BCCAO) model to investigate the improvement of SAA on cognitive dysfunction after chronic cerebral ischemia, and further explore whether it has a protective effect on hippocampal neuron damage. The mRNA changes of BCCAO model rats before and after SAA administration were analyzed based on RNA-Seq technique. Combined with GO and KEGG analysis results, PPI network analysis was performed for the major differential genes. Finally, the results were verified by western blot and enzyme-linked immunosorbent assay. After SAA treatment in BCCAO rats, behavioral experiments showed that SAA could improve learning and memory dysfunction caused by BCCAO model in rats. Moreover, it can significantly improve the hippocampal damage caused by long-term cerebral ischemia. Differential gene analysis revealed that there were multiple gene and pathway changes before and after SAA treatment. The genes we screened included TLR4, MyD88, Fos, Jun, ERK1/2, JNK and P38. Western blotting and enzyme-linked immunosorbent assay showed that SAA could regulate the TLR4/MAPKS/AP-1 signaling pathway, reduce the release of inflammatory factors, improve the nerve injury caused by brain ischemia in rats, and playing neuroprotective effects.
Cutting Performance of Tool with Continuous Lubrication of Atomized Cutting Fluid at Tool-chip Interface
Authors: Zhang Wei , Cao Tongkun 
Published: May 2022

Abstract
The application of conventional minimum quantity lubrication (MQL) will cause a large amount of oil mist particles to suspend in the air, which will harm the environment and people's health. In order to reduce the side-effects of the conventional MQL technology and the waste of cutting fluid, this paper has proposed an improved lubrication method, and a new cutting tool was fabricated. A micro-channel inside the new tool connects the tool rake face and the atomizing system, which can directly supply the atomized cutting fluid to the tool-chip contact interface for continuous lubrication. The cutting lubrication performances of the new lubrication method were compared with that of the conventional MQL, and the effectiveness of the new lubrication method was verified. The results include that the cutting force, the length of tool-chip contact, and the friction coefficient of the new lubrication method have decreased, but the cutting temperature has increased. The effect of lubricating is better than the conventional MQL. Meanwhile, the amount of the cutting fluid used by the new lubrication method has been reduced by 10 times. And the wear mechanism is dominated by adhesive wear.