bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Maternal Fluid Intake During Labor and Neonatal Weight Loss: A Review of the Literature
Authors: Glasofer Amy , Donato Shirley E. , Werfel Elizabeth , Galosi Gina , Epstein Helen-Ann Brown , Moraca Christine 
Published: August 2022

IntroductionThough in-hospital supplementation of the newborn is associated with decreased breastfeeding success, excessive neonatal weight loss is a medical indication for supplementation. Studies have theorized that maternal fluid intake during labor may impact neonatal weight loss, resulting in unnecessary supplementation. The purpose of this review was to synthesize evidence regarding the relationship between maternal fluid intake during labor and neonatal weight loss.MethodsLiterature searches were conducted in relevant databases using controlled vocabulary. The main findings and outcomes were compared across studies and calculations conducted to report the proportion of studies reporting significant findings.Results11 studies were included in the review. Overall, 7 studies (64%) identified a significant relationship between maternal fluid intake during labor and neonatal weight loss.ConclusionsGiven the risk to the newborn associated with excessive weight loss, it is not prudent to incorporate maternal fluid intake into supplementation guidelines based on existing evidence. Further research is needed before practice recommendations can be made.
Extended GRA Method for Multi-criteria Group Decision Making Problem based on Fuzzy Credibility Geometric Aggregation Operator
Authors: Qiyas Muhammad , Yahya Muhammad , Abdullah Saleem , Khan Neelam , Naeem Muhammad 
Published: August 2022

Abstract
The aim of this study is to introduce a new extended version of the GRA method for multi -criteria decision making method under the generalized fuzzy numbers. First, we develop some operational laws of credibility fuzzy numbers using the concept of Dombi norms and Bonferroni mean operator, furthermore we develop a series of aggregation operators and also discuss some basic properties like as; monotonicity , boundedness and assoicativity . Also, the core of this study is that we have developed two algorithms for multi -criteria decision making problems which is applied and to select the best option for the practical application example ( Telecom Company) of real life decision making problems. To check the validity of our developed method we have to compare with other existing methods.
Application of geographic information system (GIS) and WEB GIS for monitoring and surveillance of FMD and PPR diseases in Algeria
Authors: DAHMANI Ali , KHELIFI-TOUHAMI Nadjet Amina , BOUFENIZA Redouane-Larbi , OUCHENE Nassim , BOUFENIZA Amira , CHOURAK Asma 
Published: August 2022

Abstract
The study aimed to describe the evaluation and implementation of a spatial database that are directly or indirectly related to animal health in GIS and a web-GIS and the visualization of the spatio-temporal distribution of animal disease such as peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) in Algeria. A methodology has been adapted based on the classical steps of GIS; and performed using freely available Qgis 3.10, this methodology can be largely applied to touch different types of diseases. We have also created a model of a website «VETALGIS» (Veterinary Algerian GIS) in order to digitalize the veterinary sector and minimize the problem of lack of data, organize them and facilitate access to them which will improve networking and communication between institutions responsible for livestock disease management. GIS spatial analysis techniques have proven to be a useful tool that can support the decisionmaking process in planning, implementing and monitoring FMD and PPR control strategies in endemic and high-risk areas.
Semiconductor-Assisted Photodegradation of Azo Dye (OII), Antioxidant and Bactericidal Effect of TiO2/NiO Nanocomposite
Authors: Gul Tamanna , Saeed Khalid 
Published: August 2022

Abstract
Chemical reduction method was used to synthesize Nickle oxide nanoparticles (NiO NPs) and NiO supported on titanium dioxide (TiO2/NiO) NPs. The morphological investigation showed that neat TiO2 NPs are present in both a dispersed and agglomerated form, whereas NiO NPs are well distributed and deposited on the surface of TiO2 with size below 200 nm. The majority of the NiO NPs have a cubical form. The formation of NiO NPs was also verified by FT-IR analysis. The synthesized TiO2/NiO and NiO NPs were used as photocatalystsfor the degradation of Orange II (OII) dye. According to the degradation investigation, both NiO NPs and TiO2/NiO NPs degraded OII dye more efficiently when exposed to UV light. The results indicated that NiO NPs degraded 93% and TiO2/NiO NPs degraded approximately 96% of OII dye within 30 min. The recovered and re-recovered NPs were also significantly degraded OII dye. The effects of initial dye concentration, catalyst dosage, and pH effect were studied. Promising bioactivities were demonstrated by TiO2/NiO and NiO NPs against the pathogenic bacteria citrobacter and provedincia. TiO2/NiO NPs have strong antioxidant activity (80%) compared to the standard ascorbic acid (88%).
Mmu_circ_009056 promotes osteogenic differentiation and mineralization of BMSCs via miR-139-3p
Authors: Luo Tao , Huang Zhu , Ding Chen , Su Zhikang , Zheng Zhichao , Guo Lvhua 
Published: August 2022

Abstract
Bone remodeling is a dynamic process involving bone-forming osteoblasts and bone-resorting osteoclasts. Imbalanced bone metastases may alter the structure, mass and overall strength of the bone. Circular RNAs contribute to the osteoblastic differentiation process of stromal cells, however, the roles of which are not fully understood in bone marrow stromal cells (BMSCs). Here we reported the circular RNA mmu_circ_009056 was significantly upregulated in BMSCs undergoing osteoblastic differentiation. Knockdown of mmu_circ_009056 by siRNA decreased the expression of osteogenic genes Runx2 and Alp. Using high-throughput sequencing technique and bioinformatic tools, miR-139-3p was predicted to be a target of mmu_circ_009056, and the expression of miR-139-3p was increased after mmu_circ_009056 silencing. Moreover, inhibition of miR-139-3p increased osteoblastic differentiation of BMSCs, while miR-139-3p overexpression decreased osteoblastic differentiation and the expression of ALP and RUNX2 in BMSCs, as evidenced by Alizarin staining, RT-PCR and western blot. The paired box family member 5 (Pax5) was identified as a target gene using gene binding site prediction tools, and its expression was negatively correlated with miR-139-3p expression. Collectively, our findings demonstrate that mmu_circ_009056 plays as a regulator of miR-139-3p during osteogenic differentiation of BMSCs, and Pax5 is a potential target of miR-139-3p.
Effect of human breast milk-derived exosomes on the migration and inflammatory response of lipopolysaccharide-exposed dental pulp stem cells
Authors: Azaryan Ehsaneh , Karbasi Samira , Saharkhiz Mansoore , Hanafi-Bojd Mohammad Yahya , Zarban Asghar , Razavi Fariba Emadian , naseri mohsen 
Published: August 2022

Abstract
Aim: The purpose of this study was to investigate the effects of human breast milk-derived exosomes (HM-Exos)on the viability,migration, and inflammatory responses oflipopolysaccharide (LPS)exposed human dental pulp stem cells (HDPSCs) in vitro condition.Methods: HM-Exoswere isolated, and dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy(TEM) were used to analyze their physiological properties (size and shape).To construct an in vitro inflammation model, HDPSCs were exposed to LPS.The MTT test and migration assay were used to investigate the effect of HM-Exos on cell proliferation and migration, and the quantitative polymerase chain reaction was used to assess the expression of inflammatory genes in HDPSCs.Results: DLS measurement revealed that HM-Exos were 116.83.6 nm in diameter. The SEM and TEM images revealed spherical shapes with diameters of 97.2±34.6 nm. According to the results of the cell viability assay, the maximal nontoxic concentration of HM-Exos (400 µg/ml) was chosen for the subsequent investigations. The migration assay results showed that HM-Exos improved the potential of HDPSCs to migrate under LPS-stimulated inflammatory processes. The RT-PCR results indicated that HM-Exos significantly reduced the expression of inflammatory cytokines such as TNF-α, IL-1β and IL-6 in آHDPSCs after LPS stimulation.Conclusions: HM-Exos reduced gene expression of inflammatory cytokinesin inflamed HDPSCs and may be a viable candidate for use as a pulp capping substance in vital pulp therapy.
Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice
Authors: Mori Daisuke , Ikeda Ryosuke , Sawahata Masahito , Yamaguchi Sho , Kodama Akiko , Hirao Takashi , Arioka Yuko , Okumura Hiroki , Inami Chihiro , Suzuki Toshiaki , Hayashi Yu , Kato Hidekazu , Nawa Yoshihiro , Miyata Seiko , Kimura Hiroki , Kushima Itaru , Aleksic Branko , Mizoguchi Hiroyuki , Nagai Taku , Nakazawa Takanobu , Hashimoto Ryota , Kaibuchi Kozo , Kume Kazuhiko , Yamada Kiyofumi , Ozaki Norio 
Published: August 2022

Abstract
Whole genome analysis has identified rare copy number variations (CNV) that are strongly involved in the pathogenesis of psychiatric disorders, and 3q29 deletion has been found to have the largest effect size. The 3q29 deletion mice model (3q29-del mice) has been established as a good pathological model for schizophrenia based on phenotypic analysis; however, circadian rhythm and sleep, which are also closely related to neuropsychiatric disorders, have not been investigated. In this study, our aims were to reevaluate the pathogenesis of 3q29-del by recreating model mice and analyzing their behavior and to identify novel new insights into the temporal activity and temperature fluctuations of the mouse model using a recently developed small implantable accelerometer chip, Nano-tag. We generated 3q29-del mice using genome editing technology and reevaluated common behavioral phenotypes. We next implanted Nano-tag in the abdominal cavity of mice for continuous measurements of long-time activity and body temperature. Our model mice exhibited weight loss similar to that of other mice reported previously. A general behavioral battery test in the model mice revealed phenotypes similar to those observed in mouse models of schizophrenia, including increased rearing frequency. Intraperitoneal implantation of Nano-tag, a miniature acceleration sensor, resulted in hypersensitive and rapid increases in the activity and body temperature of 3q29-del mice upon switching to lights-off condition. Similar to the 3q29-del mice reported previously, these mice are a promising model animal for schizophrenia. Successive quantitative analysis may provide results that could help in treating sleep disorders closely associated with neuropsychiatric disorders.
Strategy to improve endogenous bone regeneration of 3D-printed polycaprolactone/hydroxyapatite composite scaffold: Collagen designs with bone morphogenetic protein 2 and fibroblast growth factor 2
Authors: Cho Yong Sang , Ghim Min-Soo , Hong Myoung Wha , Kim Young Yul , Cho Young-Sam 
Published: August 2022

Abstract
In bone tissue engineering, the endogenous regeneration of bone defects still represents a clinical challenge despite the development of intervention therapy to achieve bone regeneration via autologous grafts, allogeneic grafts, bone morphogenetic protein (BMP)-2, etc. To overcome the limitation of endogenous bone regeneration, we assumed that the 3D-printed collagen pattern with BMP-2 and fibroblast growth factor (FGF)-2 in the 3D-printed polycaprolactone/nano-hydroxyapatite scaffold could guide the endogenous regeneration of bone defects. Therefore, to test our hypothesis, polycaprolactone/nano-hydroxyapatite/collagen scaffolds with dual growth factors (BMP-2 and FGF-2) and various hydrogel patterns (positive, edge, and radial patterns) were fabricated at the same ratio and concentration of dual growth factors. Consequently, we revealed that the in vitro released concentrations of BMP-2 and FGF-2 were not affected by collagen patterns in the PCL/nano-hydroxyapatite scaffold. Furthermore, endogenous bone regeneration and angiogenesis in the polycaprolactone/nano-hydroxyapatite/collagen scaffold with a radial pattern were promoted compared with those in the polycaprolactone/nano-hydroxyapatite/collagen scaffolds with positive and edge patterns. Therefore, we demonstrated that a collagen design loaded with dual growth factors in the 3D-printed scaffold could affect endogenous bone regeneration and angiogenesis.
Research on Development of Global Creative Center Cities from Regional Perspective: A case study of creative industries of Milan
Authors: Shen Cheng , Zhang Xinyi , Li Xiang 
Published: August 2022

Abstract
With the advancement of globalization and the deepening of the interlock between cities worldwide, the research on urban culture and creative development should be expanded from single city scale to regional and urban agglomeration scale, and creative clusters will become an important spatial scale to break the bottleneck of urban development in the future. In Europe, cities such as London, Paris and Milan have developed creative industries and built creative clusters earlier and then gradually become global creative centers. However, there are few studies on the development of their creative industries from a regional perspective. This research uses multi-source data, within the scope selected based on comprehensive standards, to analysis regional development characteristics of creative industries in Milan, creative clusters formed with Milan as its core and influencing factors of the development. Through the study of a global creative center from regional perspective, references for emerging creative cities and cities that need industrial transformation can be concluded.
Dosimetric impact of metal artifact reduction for spinal implants in stereotactic body radiotherapy
Authors: Li Bin , Huang Jiexing , Ruan Junjie , Peng Qinghe , Huang Sijuan , Li Yunfei , Li Fanghua 
Published: August 2022

Abstract
Background
Metal artifacts due to spinal implants can affect the accuracy of dose calculation for radiotherapy. However, the dosimetric impact of metal artifact reduction for spinal implants in Stereotactic Body Radiotherapy (SBRT) plans has not been well studied. The purpose of this study was to evaluate the dosimetric impact of a commercial metal artifact reduction method for different commercial dose calculation algorithms in spinal SBRT planning.
Methods
A gammex phantom and 10 clinical computed tomography (CT) images were selected to investigate the effects of titanium implants. To achieve metal artefact suppression, a commercial orthopedic metal artifact reduction (OMAR) algorithm was employed. Dose calculations for SBRT were conducted on both uncorrected and artifact-suppressed images using three commercial algorithms (Analytical Anisotropic Algorithm (AAA), Acuros XB(AXB) and Monte Carlo (MC)). Dose discrepancies between artifact-uncorrected and artifact-suppressed cases were appraised using Dose Volume histograms (DVH) and 3D gamma analysis with different distance to agreement (DTA) and dose difference criteria. Gamma agreement index (GAI) was denoted as G(∆D, DTA).
Results
No significant dose differences between the artifact-uncorrected and artifact-corrected datasets were observed for titanium spinal implants. For all parameters of DVH, average differences did not exceed 0.7% in PTV and 2.08% in PRV SC. Gamma index test yielded G(3,3) ≥ 99.8%, G(2,2) > 99.2% and G(1,1) > 93.8% for all patient cases. Moreover, MC algorithm was found to be more sensitive to the presence of titanium inserts compared to AXB and AAA.
Conclusions
Dosimetric impact of artifacts caused by titanium implants is not significant in spinal SBRT plan, which indicates that dose calculation algorithms might not be very sensitive to CT number variation caused by titanium inserts. In addition, MC algorithm has higher sensitivity to the presence of metal artifacts than that of AXB and AAA algorithms, indicating that MC is preferable for dose calculation in spinal SBRT planning.
Feasibility study of non-invasive evaluation of human PD-1 expression using 125I-nivolumab in a mouse tumor model
Authors: Park Seri , Vinod Nagarajan , Kim Deok Il , Lim Ilhan 
Published: August 2022

Abstract
The immune checkpoint inhibitor, nivolumab, promotes robust antitumor efficacy in terms of blocking programmed cell death-1 (PD-1). The need is increasing to develop non-invasive imaging approach for evaluating human PD-1 (hPD-1) expression in tumors. The purpose of this study is to investigate whether we can evaluate the human PD-1 (hPD-1) expression non-invasively using 125I-nivolumab in a tumor model. Firstly, we confirmed the hPD-1 expression in Raji-hPD-1 cells by flow cytometry. In vitro cell binding assay for the determination of immunoreactivity showed specific binding of 125I-nivolumab to hPD-1 receptors of Raji cells and the dissociation constants (Kd) was 4.41 nM. Most importantly, single photon emission computed tomography/CT (SPECT/CT) images indicated that 125I-nivolumab uptake in Raji-hPD-1 tumor group showed higher than that of cold blocking group at 48 h and 168 h. In addition, we found that the signal intensity of hPD-1 expressing Raji tumor revealed 4.5-fold higher 125I-nivolumab uptake compared to Raji-null tumor (P<0.05) by autoradiography. Taken together, we established the labeling technique of 125I-nivolumab to evaluate the expression of human PD-1 non-invasively in a mouse tumor model. This technique might be developed further for the clinical application of non-invasive evaluation of hPD-1.
Evidence of Downregulation in Atmospheric Nitrogen-Fixation Associated with Native Hawaiian Sugarcane (Saccharum officinarum L.) Cultivars
Authors: Lincoln Noa Kekuewa , Santiago Paul , Tatum Derek , Valle-Echevarria Angel R. Del 
Published: August 2022

Abstract
Aims
The study of nitrogen fixation in sugarcane has a long history that has demonstrated high potential but with substantial variation in results. This 32-month study sough to assess the response of nitrogen fixation associated with sugarcane (Saccharum officinarum L. cvs. ‘Akoki, Honua‘ula, and ‘Ula) to available soil nitrogen.
Methods
Plants were grown in large pots of perlite along with a fixing and a non-fixing plant control, and administered liquid fertigation with varying amounts of isotopically enriched nitrogen. Assessment of nitrogen fixation utilized nitrogen isotope tracing and acetylene reduction assay in the target and control plants.
Results
Isotope enrichment and acetylene reduction assay both indicated that nitrogen fixation peaked under low nitrogen application, and declined with higher application rates, with agreement between the two methods. These results suggest that sugarcane engages in a downregulation of nitrogen fixation under high nitrogen availability, potentially explaining the high variation in published experimental results.
Conclusion
This suggests that nitrogen management and fertilization strategy can impact the atmospheric inputs of nitrogen in sugarcane cultivation, and the potential to improve nitrogen application efficiency in cropping systems utilizing sugarcane.
Preoperative Omega-6/Omega-3 Fatty Acid Ratio predicts postoperative outcomes in patients with surgically resected Non-Small Cell Lung Cancer
Authors: Déniz Carlos , Raba-Parodi Carla , García Eva , Macía Iván , Rivas Francisco , Ureña Anna , Muñoz Anna , Moreno Camilo , Serratosa Ines , Masuet-Aumatell Cristina , Escobar Ignacio , Ramos Ricard 
Published: August 2022

Abstract
Background
The aim of this study was to determine whether preoperative nutritional status and inflammatory status, specifically the omega fatty acids and the omega 6/3 ratio, would affect postoperative outcomes and complications in patients with lung cancer undergoing lung resection.
Methods
This prospective observational study included 68 patients with early-stage non-small cell lung cancer who were candidates for radical surgery. A complete nutritional assessment was performed. The primary study variable was postoperative complications and mortality in the first 30 days. Descriptive, bivariate, logistic regression analysis was carried out.
Results
A total of 50 men (73.53%) and 18 women (26.47%) underwent surgery, with a median age of 64.2 (± 9.74) years. The mean omega 6/3 ratio was 17.39 (± 9.45). A complication occurred in 39.7% of the study sample (n = 27), the most common being persistent air leak, in 23.53% (n = 16). After performing bivariate analysis taking the omega 6/3 ratio as a qualitative variable, we observed that the omega 6/3 ratio had prognostic value for persistent air leak (p = 0.001) independently of age, sex, comorbidity, preoperative respiratory function and approach or type of surgery. The remaining nutritional and inflammatory markers did not have a statistically significant association (p > 0.05) with postoperative complications. On multivariate analysis with an omega 6/3 ratio cut-off of 21, the only variable that remained significant was COPD (p = 0.03; 95% CI: 1.22–53.57).
Conclusions
Omega 6/3 ratio is a prognostic factor for air leak, independently of the patient’s clinical and pathological characteristics.
Analysis of the dynamics of temperature in the northern part of Cameroon
Authors: Yaouba Bassirou , Dieudonné Bitondo 
Published: August 2022

Abstract

The northern part of Cameroon is reported to be vulnerable to climate change and heavily dependent on agriculture. However, few studies have considered the evolution of climatic data that influence agriculture. Existing studies are rarely based on field data. The assessment of precipitation has gained more attention than that of temperature. Few publications have addressed temperature dynamics, and this research contributes to closing that gap by studying the dynamics of three temperature parameters, namely, maximum, minimum and mean temperatures. Data from 1973 to 2020 were collected from weather stations located in three major cities in northern Cameroon: Ngaoundere, and Garoua, from the weather stations of the Agency for Aerial Navigation Safety in Africa and Madagascar (ASECNA); and Maroua, from the weather station of the Cameroon Civil Aviation Authority (CCAA). The study reveals that in Ngaoundere, the minimum temperature increased by 8.7% between 1987 and 2020 compared to 1973–1987. In Garoua, the mean temperature increased by 2.2% between 2003 and 2020 compared to 1973–2002, the minimum temperature increased by 13.3% between 1985 and 2020 compared to 1973–1984, and the maximum temperature decreased by -8.2%. In Maroua, the mean temperature increased by 3.6% between 2002 and 2020 compared to 1973–2001, and the minimum temperature also increased by 17.8% between 1990 and 2020 compared to 1973–1989; however, the maximum temperature decreased by -6.8% between 1988 and 2020 compared to 1973–1987. The results of this study will be used as the basis for forecasting future agricultural conditions.