bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taxanes plus cetuximab with or without platinum chemotherapy after progression on immune checkpoint inhibitors in patients with squamous cell carcinoma of the head and neck.
Authors: Saleh Khalil , Vinches Marie , Safta Inga , Guiard Emeline , Marret Gregoire , Vion Roman , Guigay Joel , Ferrand François-Régis , Clatot Florian , Le Tourneau Christophe , Rambeau Audrey , Saada-Bouzid Esma , Daste Amaury , Even Caroline 
Published: July 2022

6036 Background: Salvage chemotherapy after progression on immune checkpoint inhibitors (ICIs) was associated with an objective response rate (ORR) of 30% in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). We aimed to investigate the efficacy of taxanes + cetuximab (TC) +/- platinum chemotherapy in pts with R/M SCCHN who failed ICIs in palliative setting. Methods: A retrospective study was conducted at 7 French university hospitals. Eligibility criteria were pts treated with ICI for R/M SCCHN, who progressed after treatment with ICI and received TC +/- platinum salvage chemotherapy between August 2017 and December 2021. Clinical and radiological data and outcome were collected from review of medical records. Results: Ninety-nine pts met eligibility criteria: 63 pts received TC and 36 pts received triplet regimen (TR). The median age was 61 years (range 24-78) and 79% of pts were male. Forty-two pts (42%) had platinum-refractory disease (PRD) after multimodal treatment, 13 pts received prior taxanes and 24 pts received prior cetuximab. The median PS at salvage chemotherapy was 1 (range 0-3). ICIs were given as first-line treatment in 70% of pts including those with PRD. The ORR of the entire cohort was 62% (61/99) including 5 complete responses (CR) and the disease control rate was 79% (78/99). The median progression-free survival of the entire cohort was 4.4 months and the median overall survival (OS) was 7.5 months. The 5 pts who had CR as best response are still in remission after a median follow-up of 24 months (range 8-58). The ORR of TC subgroup was 57% (36/63) and the ORR of TR subgroup was 69% (25/36). Furthermore, the ORR in the PRD subgroup of pts was 54% (39/72), and the ORR in the subgroup of pts who were not chemo naïve was 54% (39/72). The ORR in pts who previously received cetuximab was 50% (12/24) vs 75% (49/75) in those who did not. The ORR in pts who previsouly received taxanes was 38% (5/13) vs 65% in those who did not. Finally, the ORR in PRD pts and treated with TR was 50% (7/14) and the ORR in pts who previously received platinum-based treatment or PRD and treated with TR was 55% (11/20). Conclusions: TC +/- platinum chemotherapy was highly effective in pts R/M SCCHN who progressed on ICIs with an ORR of 62% and DCR of 79%. Further investigations are warranted.
Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids
Authors: Maeda Ryo , Tamagaki-Asahina Hiroko , Sato Takeshi , Yanagawa Masataka , Sako Yasushi 
Published: July 2022

ABSTRACT
The cytoplasmic domain of receptor tyrosine kinases (RTKs) plays roles as a kinase and a protein scaffold; however, the allocation of these two functions is not fully understood. Here, we analyzed the assembly of the transmembrane (TM)–juxtamembrane (JM) region of EGFR, one of the best studied members of RTKs, by combining single-pair fluorescence resonance energy transfer (FRET) imaging and a nanodisc technique. The JM domain of EGFR contains a threonine residue (T654) that is phosphorylated after ligand association. We observed that the TM–JM peptides of EGFR form anionic lipid-induced dimers and cholesterol-induced oligomers. The two forms involve distinct molecular interactions, with a bias toward oligomer formation upon threonine phosphorylation. We further analyzed the functions and oligomerization of whole EGFR molecules, with or without a substitution of T654 to alanine, in living cells. The results suggested an autoregulatory mechanism in which T654 phosphorylation causes a switch of the major function of EGFR from kinase-activating dimers to scaffolding oligomers.
Η σύνδεση της Πανδώρας με την πρώιμη αρχαϊκή εποχή στο Ἔργα καὶ Ἡμέραι
Authors: Αναστασιάδου Χριστίνα 
Published: July 2022

Βασικός πυρήνας της παρούσας εργασίας αποτελεί η ερμηνεία και η συμβολή της Πανδώρας για το σιδηρό γένος στο Ἔργα καὶ Ἡμέραι του Ησιόδου. Αρχικά, υπογραμμίζεται η συμβολή του Μύθου στην ανάπτυξη του φιλοσοφικού στοχασμού, καθώς και η συνεισφορά του Ησιόδου στη γέννηση της φιλοσοφίας. Έπειτα, επιχειρείται η συσχέτιση της μορφής της Πανδώρας με τα διανοητικά στοιχεία της πρώιμης αρχαϊκής περιόδου. Ακολούθως, πραγματώνεται μια ερμηνευτική σύνδεση ανάμεσα στον Προμηθέα και την Πανδώρα προτάσσοντας την έννοια του μόχθου για το σιδηρό γένος και, τέλος, διαπιστώνεται η αξία της Πανδώρας ως μια καίρια παρουσία για τη διαμόρφωση του σιδηρού και κατ’ επέκταση του ανθρώπινου γένους.
Η πολιτική ιδεολογία του φασισμού και η Νεωτερικότητα
Authors: Ζαχαράκης Μύρων 
Published: July 2022

Στο παρόν άρθρο θα εξεταστεί η σχέση της πολιτικής ιδεολογίας που είναι γνωστή ως «φασισμός» με τις αξίες της Νεωτερικότητας, με σκοπό να αναιρεθεί η ευρέως διαδεδομένη παρερμηνεία ότι ο φασισμός αποτελεί ένα ιδιαίτερο είδος «πολιτικού λουδισμού», δηλαδή μια ακραία αντίδραση απέναντι στη Νεωτερικότητα, καθώς και μια αταβιστική παλινδρόμηση στον μυθικό τρόπο σκέψης, κυρίως εξαιτίας της επιρροής του από τον ρομαντισμό του 19ου αιώνα. Αφού αναιρεθεί αυτή η άποψη, θα προβληθεί η δισυπόστατη φύση του φασισμού, ως μια σύζευξη τεχνοκρατίας και αντιμοντερνισμού, και επιπλέον η γενικότερη σχέση του με το κίνημα του ρομαντισμού.
Wideband dual-polarized linear-circular and linear-cross angular stable THz reflective polarizer based on a modified square loop FSS
Authors: Shukoor Mohammad Abdul , Bini Tejas Shibu , Kunju Nissan , Dey Sukomal 
Published: July 2022

A simple wideband reflective type linear-cross and linear-circular polarization converter for terahertz (THz) applications is proposed in this paper. The top frequency selective surface (FSS) consists of a thin gold coated figure of eight square loop with the connected strip line corners on a thin grounded polyamide dielectric substrate. For the

y

/

x

-polarized incidence, the design exhibits linear-circular conversion with an axial ratio (

≤

3

d
B

) from 0.49–0.50, 0.60–0.83, 1.16–1.62, and 1.81–1.85 THz with 2.02%, 32.17%, 33.09%, and 2.19% fractional bandwidth (FBW), respectively. In addition, it also performs the linear-cross conversion with a minimum 90% polarization conversion ratio (PCR) from 0.53–0.56, 0.92–1.07, and 1.69–1.75 THz having 5.50%, 15.08%, and 3.49% FBW, respectively. Multiple plasmonic resonances are the reason behind different polarization conversions and are confirmed with surface current distribution profiles of the FSS and ground. The metasurface’s performance is stable up to 45° for both transverse electric (TE) and transverse magnetic (TM) oblique incidences. The polarizer’s unit cell architecture is compact with structural dimensions of

0.121

×

0.121

×

0.041

λ
L
3

, where

λ
L

is the lowest operating frequency’s free-space wavelength. The authors believe this design is compact, with angular stable multi-band multi-conversion ability that will significantly impact the THz applications in real time.
Oral doxycycline prevents skin-associated adverse effects induced by injectable collagenase in a rodent model of capsular contracture around silicone implants
Authors: Diehm Yannick F. , Kotsougiani-Fischer Dimitra , Porst Elena , Haug Valentin , Siegwart Laura C. , Overhoff Daniel , Kneser Ulrich , Fischer Sebastian 
Published: July 2022

Background
The collagenase of the bacterium Clostridium histolyticum (CCH) is already an established treatment for fibroproliferative diseases like M. Dupuytren and M. Peyronie Although results are comparable to surgical intervention, skin laceration is a severe and relevant side effect. Doxycycline (DOX) recently rose interest as an inhibitor of matrix-metalloproteinases alongside its capabilities of skin accumulation. It therefore might be a potential skin protective agent in the use of CCH.

Methods
For simulation of a fibroproliferative disease adjacent to the skin, we utilized a rodent model of capsular fibrosis involving silicone implants and subsequent fibrotic capsule formation. For in-vitro studies, fibrotic capsules were excised and incubated with 0.9 mg/ml CCH and four different doses of DOX. For in-vivo experiments, animals received 0.0, 0.3 or 0.9 mg/ml CCH injections into the fibrotic capsules with or without prior oral DOX administration. Outcome analysis included histology, immunohistochemistry, gene expression analysis, chemical collagen and DOX concentration measurements as well as μCT imaging.

Results
In-vitro, DOX showed a dose-dependent inhibition of CCH activity associated with increasing capsule thickness and collagen density and content. In-vivo, oral DOX administration did neither interfere with capsule formation nor in effectiveness of CCH dissolving fibrotic capsule tissue. However, skin thickness and especially collagen density was significantly higher compared to control groups. This led to a reduced rate of clinical skin lacerations after DOX administration.

Conclusion
DOX inhibits CCH and accumulates in the skin. Thereby, DOX can effectively reduce skin laceration after CCH treatment.
Porto-Sinusoidal Vascular Disease in a Patient With Diffuse Aortitis and Massive Ascites
Authors: Lin Emily , Lee Brian T. 
Published: July 2022

ABSTRACT
A 69-year-old man with no history of liver disease presented with massive ascites. Imaging demonstrated diffuse wall thickening of the entire aorta, renal pelvis, and ureters along with an enlarged main portal vein, portosystemic collaterals, and peritoneal thickening concerning for large vessel vasculitis. Liver biopsy was consistent with obliterative portal venopathy. The patient was started on corticosteroid therapy with improvement in his ascites. This case study reveals a rare association between vasculitis and portal-sinusoidal vascular disease and idiopathic non-cirrhotic portal hypertension, highlighting the heterogenous clinical presentation of this disease entity.
Pengembangan Buku Bacaan Berjenjang Mata Pelajaran IPA Untuk Siswa Sekolah Dasar
Authors: Anisa Nur Izza Fitria  
Published: July 2022

Penelitian ini merupakan penelitian pengembangan (R&D) menggunakan model 4D, yaitu Define, Design Develope, dan Disseminate. Namun, pengembangan ini hanya pada sampai tahap Develope. Penelitian ini bertujuan untuk mengetahui karakteristik produk buku bacaan berjenjang dan mengetahui kualitas produk yang dikembangkan. Penilaian dilakukan melalui ahli materi, ahli media, dan guru IPA SD yang meliputi 9 aspek penilaian dengan menggunakan instrumen lembar penilaian skala 4. Hasil penilaian berupa data kuantitatif dan kualitatif yang kemudian dianalisis dengan pedoman kriteria penilaian ideal untuk menentukan kualitas buku bacaan berjenjang. Produk yang dikembangkan direkomendasikan untuk kelas IV tema 2 pokok bahasan energi dan kelas V tema 3 pokok bahasan sistem pencernaan manusia yang diberi judul “Yuk, Cari Tahu”. Karakteristik produk terdiri dari 20 halaman yang dikemas dalam bentuk cerita dan terdiri dari satu gambar tiap halaman. Berdasarkan penilaian ahli materi menunjukkan bahwa kualitas buku Baik (SB) dengan skor 2 dari total skor 2, penilaian ahli media menunjukkan bahwa kualitas buku Sangat Baik (SB) dengan skor 6 dari total skor 6 dan penilaian guru IPA SD menunjukan bahwa kualitas buku Sangat Baik (SB) dengan skor 31,2 dari total skor 36 dengan persentase keidealan sebesar 87%. Oleh karena itu, produk pengembangan layak dijadikan sebagai media pembelajaran.
Family Context, Identity and Internet Use: A Cross-Sectional Study in a Group of Italian Adolescents During COVID-19 Pandemic
Authors: Monica Pellerone , Razza Stesy Giuseppa , Torvisco Juan Martinez , Lo Piccolo Alessandra 
Published: July 2022

Literature has demonstrated the adaptive function of identity development and family context toward manifestation of problem behaviors in adolescence.
The present research investigates: a) the influence of dysfunctional family dynamics on the Internet use; b) the impact that psychological and physical sensations - following excessive Internet use - can have on the quality of family relationships.
The research involved 150 Italian students (65 males and 85 females) aged between 14 and 20 years (M =15.99, S.D = 1.94). The research lasted for 1 school year.
Participants completed: an anamnestic questionnaire; the Family Assessment Device (FAD) in order to value the family functioning; and a self-report constructed ad hoc questionnaire, named “Adolescents and Digital Technologies” to measure frequency of use of social networks and Internet, the motivation for the use of social networks, the physical and psychological sensation perceived following their use.
Data show the influence of gender and age on the general use of Internet; the influence of gender on psychological and physical sensations experienced by adolescent participants while using the Internet; and the predictive role of the family emotional involvement on Internet use.
Family is a context for learning models and values that affect the wider social and regulatory context, and for this reason it is considered the privileged context in which to intervene to reduce behavioral problems of adolescents.
Capitalism, Justice, and the Boundaries of Liberalism
Authors: Lukes Steven 
Published: July 2022

Abstract
The argument of Katrina Forrester’s In the Shadow of Justice explains the present neglect of Rawlsian thinking in the social and political world beyond academia. She there convincingly shows how its deep assumptions, conceptual framing and narrow view of what constitutes politics disabled it from grappling with the subsequent massive transformations of capitalism. Her second argument, advanced in her article and questioned here, offers an ideology critique of Rawlsian thinking that claims, in its strongest version, that such thinking fails to acknowledge that capitalism is not reformable and that this failure derives from its liberal assumptions. What is needed, she claims, is a critique that implies the feasibility of attaining a post-capitalist world that is based on a theory that goes beyond the boundaries of liberalism.
Positive solutions for fractional differential equation at resonance under integral boundary conditions
Authors: Wang Youyu , Huang Yue , Li Xianfei 
Published: July 2022

Abstract
By using the theory of fixed point index and spectral theory of linear operators, we study the existence of positive solutions for Riemann-Liouville fractional differential equations at resonance. Our approach will provide some new ideas for the study of this kind of problem.
The “Core Actions” and “Uniquely Colorful Lyricism” of New Mainstream Films
Authors: Zhou Anhua 
Published: July 2022

Abstract
In 2020, new domestic mainstream films continued to challenge audience expectations and achieve breakthroughs. These films not only are characterized by representations that are universally appealing to contemporary tastes, but also integrate the desires and interests of the public. They have become mainstream films because they are full of realistic content and true sentiments. Regarding the narrative esthetics and ideological strategies of these films, the three new “core actions” make the powerful trend of “uniquely colorful lyricism” appear brilliantly on the screen. These core actions are: (1) revealing the true nature of life and struggle by strengthening the sense of opposing forces; (2) emphasizing comedic elements to highlight low-level esthetic charms; and (3) creating open spaces and thematic implications through the use of different phases. Obviously, it has been the inevitable choice of new mainstream films to restore sincerity and truth of the screen, to sense the changes in people and society, and to interpret the new modern and contemporary histories in ways that originated from, but rise above, reality.
Overexpression of miR-100-5p inhibits papillary thyroid cancer progression via targeting FZD8
Authors: Ma Peng , Han Jianli 
Published: July 2022

Abstract
Papillary thyroid cancer (PTC) is the most prevalent type of TC worldwide; however, its pathological process remains unclear at the molecular level. In the current study, we analyzed the microarray data of PTC tissues and non-neoplastic thyroid tissues, and confirmed miR-100-5p as a downregulated miRNA in PTC. Via bioinformatic approach, western blotting, and TOP/FOP-flash assay, miR-100-5p was observed to be involved in the inactivation of Wnt/β-catenin signaling in TPC-1 and KTC-1. Frizzled Class Receptor 8 (FZD8), the coupled receptor for canonical Wnt/β-catenin signaling, was verified to be targeted and inhibited by miR-100-5p in TPC-1 and KTC-1. In the function assay, miR-100-5p mimic repressed PTC cell proliferation and induced cell apoptosis of TPC-1 and KTC-1; meanwhile, transfection of full-length FZD8 attenuated the effect of miR-100-5p mimic. Moreover, in the collected samples, miR-100-5p was lowly expressed in PTC tissues compared with normal tissues, especially in those of advanced stage (Stage III/IV vs Stage I/II), while FZD8 was highly expressed in PTC tissues, which in PTC tissues was inversely correlated to miR-100-5p. Thus, we suggest that overexpression of miR-100-5p inhibits the development of PTC by targeting FZD8.
Bioinformatics analysis reveals three key genes and four survival genes associated with youth-onset NSCLC
Authors: Han Xuan , Ren Peng , Ma Shaohua 
Published: July 2022

Abstract
Youth-onset non-small cell lung cancer (NSCLC) is a heterogeneous disease. It has a unique clinicopathology and special genetic background. In this study, three key genes, CDC20, CCNB2, and BUB1, have been identified in youth-onset NSCLC tumor tissues based on the TCGA and GEO cohorts. Functional enrichment analysis reveals that the “oocyte meiosis,” “cell cycle,” and the “P53 signaling pathway” are significantly enriched. Additionally, four survival genes, including AKAP12, CRIM1, FEN1, and SLC7A11, that affect the prognosis of youth-onset NSCLC patients are identified in this study. Finally, we construct a risk model to predict the overall survival of youth-onset NSCLC patients, the AUC of the risk model in 1, 3, and 5 years of overall survival is 0.808, 0.844, and 0.728. This study aims to provide a novel idea to explore the pathogenic genes of youth-onset NSCLC.
Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation
Authors: Liu Yang , Wang Xiang , Zeng Xingzhi , Wu Yinghua , Liu Xinrong , Tan Juan , Li Xiaoyan 
Published: July 2022

Abstract
The function of small ubiquitin-like modifier (SUMO)-related genes in hepatocellular carcinoma (HCC) remains unclear. This study aimed to analyze the expression profile and prognostic relevance of SUMO-related genes using publicly available data. A set of bioinformatics tools and experiments were integrated to explore the mechanism of the genes of interest. The least absolute shrinkage and selection operator Cox regression analysis was used to construct a prognostic model. SUMO-2 and SUMO-activating enzyme subunit 1 (SAE1) were upregulated in HCC. The enrichment analysis indicated that SUMO-2 and SAE1 might regulate the cell cycle. The downregulation of SAE1 inhibited the proliferation of HCC cells, whereas the upregulation of the gene promoted cell proliferation. IGF2BP3 contributed to the upregulation of SAE1 in an N6-methyladenosine (m6A)-dependent way. Eventually, an SAE1-related risk score (SRRS) was developed and validated in HCC. SRRS could serve as an independent prognostic factor and predict the efficiency of transarterial chemoembolization in patients with HCC.
Effect of thermomechanical processing on the mechanical properties of CuZn10 alloy
Authors: Yilmaz S. Osman , Teker Tanju , Batmaz Yaşar Onur , Yüksel Çağlar 
Published: July 2022

Abstract
The effects of thermomechanical processing on the grain size, tensile strength, and strain rate of a CuZn10 alloy were investigated. Microstructures of thermomechanically treated samples were introduced using a scanning electron microscope. The relationships between the flow stress, reduction ratio, annealing temperatures, and strain rates were detected for determination of activation energies and optimized thermomechanical parameters. The effect of grain size on the mechanical properties was examined by tensile and microhardness tests. The typical fractographs of samples after tensile tests were examined using a scanning electron microscope. It was observed that the annealing temperature and aging time have significant effects on the optimum grain size. Mechanical properties of the thermomechanically treated samples were improved by strain rate, deformation ratio, annealing temperature, and aging time.
Crystal structure of 9-(t-butyl)-3,11-dihydro-6H-pyrazolo [1,5-a]pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-6-one hemihydrate, C30H32N10O3
Authors: Song Zhi-Qiang , Hou Ying-Jie , Sun Hai-Yang , Zhong Qi-Di 
Published: July 2022

Abstract
C30H32N10O3, monoclinic, P21/c (no. 14), a = 10.447(2) Å, b = 20.130(4) Å, c = 14.772(3) Å, β = 113.001(3)°, V = 2859.7(10) Å3, Z = 4, R

gt
(F) = 0.0556, wR

ref
(F
2) = 0.1663, T = 296 K.
The finite element modeling of the impacting process of hard particles on pump components
Authors: Li Qingyu , Jing Laiyi , Sun Qunying , Ji Li , Chen Songying 
Published: July 2022

Abstract
Shield pumps which transport a variety of complex media are widely used in chemical industry, mineral industry, and other fields. However, the hard particles in the media erode the flow passage in the shield pump, seriously affecting the service life of the pump. Therefore, it is important to study the erosion process in the flow passage to extend the service life of the pump. This erosion process in the shield pump can be investigated by experiments, but it is difficult for the current experimental method to copy the real industrial service environment of impellers. For example, the environment temperature and speed range are found difficult to be reached by the current experimental method. Comparatively, the simulation by finite element method can overcome the above deficiency. In this article, the ANASYS software is used to simulate the erosion process in shield pump flow passage due to hard particles. Specifically, the structural static analysis module is used to build the model of thermal barrier coating components and hard particle components. Then the variation law of stress, strain, and material deformation of the flow passage components under concentrated force is obtained. Second, the extended finite element method is used to study the crack propagation caused by the erosion process. A linear elastic–linear softening constitutive model is established to simulate the stress variation during the crack propagation and material removal under the continuous erosion from hard particles. The proposed law regarding stress variation and crack propagation in the erosion process in this study contributes to theoretical support for damage detection and service life extension of shield pumps.