bluuebunny/crossref_metadata_2025_split huggingface dataset:
The temporal association of hyperhidrosis and its comorbidities – a nationwide hospital‐based cohort study
Authors: Henning M.A.S. , Reguant R. , Jørgensen I.F. , Andersen R.K. , Ibler K.S. , Pedersen O.B. , Jemec G.B.E. , Brunak S. 
Published: June 2022

AbstractBackgroundResearch on hyperhidrosis comorbidities has documented the co‐occurrence of diseases but has not provided information about temporal disease associations.ObjectiveTo investigate the temporal disease trajectories of individuals with hospital‐diagnosed hyperhidrosis.MethodsThis is a hospital‐based nationwide cohort study including all patients with a hospital contact in Denmark between 1994 and 2018. International Classification of Diseases version‐10 diagnoses assigned to inpatients, outpatients and emergency department patients were collected from the Danish National Patient Register. The main outcome was the temporal disease associations occurring in individuals with hyperhidrosis, which was assessed by identifying morbidities significantly associated with hyperhidrosis and then examining whether there was a significant order of these diagnoses using binomial tests.ResultsOverall, 7 191 519 patients were included. Of these, 8758 (0.12%) patients had localized hyperhidrosis (5674 female sex [64.8%]; median age at first diagnosis 26.9 [interquartile range 21.3–36.1]) and 1102 (0.015%) generalized hyperhidrosis (606 female sex [59.9%]; median age at first diagnosis 40.9 [interquartile range 26.4–60.7]). The disease trajectories comprised pain complaints, stress, epilepsy, respiratory and psychiatric diseases. The most diagnosed morbidities for localized hyperhidrosis were abdominal pain (relative risk [RR] = 121.75; 95% Confidence Interval [CI] 121.14–122.35; P < 0.001), soft tissue disorders (RR = 151.19; 95% CI 149.58–152.80; P < 0.001) and dorsalgia (RR = 160.15; 95% CI 158.92–161.38; P < 0.001). The most diagnosed morbidities for generalized hyperhidrosis were dorsalgia (RR = 306.59; 95% CI 302.17–311.02; P < 0.001), angina pectoris (RR = 411.69; 95% CI 402.23–421.16; P < 0.001) and depression (RR = 207.92; 95% CI 202.21–213.62; P < 0.001). All these morbidities were diagnosed before hyperhidrosis.ConclusionsThis paper ascertains which hospital‐diagnosed morbidities precede hospital‐diagnosed hyperhidrosis. As hyperhidrosis mainly is treated in the primary health care sector, the trajectories suggests that these morbidities may lead to a worse disease course of hyperhidrosis that necessitates treatment in hospitals. Treating these morbidities may improve the disease course of hyperhidrosis.
Integrated multivariate analysis as a tool to evaluate effects of ultrasound on beef quality
Authors: Caraveo‐Suarez Reyes Omaro , Garcia‐Galicia Iván Adrián , Santellano‐Estrada Eduardo , Carrillo‐Lopez Luis Manuel , Huerta‐Jimenez Mariana , Alarcon‐Rojo Alma Delia 
Published: June 2022

AbstractAn important controversy in the effect of high‐intensity ultrasound (HIU) on beef physicochemical properties exists among studies. This study aimed to analyze physicochemical data from several experiments in order to determine the most effective HIU treatment for the quality improvement of meat. Multivariate analysis was used to define the main effects attributed to the application of HIU, packaging, and storage of beef. A data set containing 104 individual records of color parameters (L*, a*, b*, C* and Hue*), drip loss, water‐holding capacity, and shear force from beef muscles under different treatments (HIU, packaging, storage) was constructed. All the evaluated variables presented changes by the effect of the treatments. The cluster analysis in the MANOVA analysis showed the formation of 12 groups with significant differences (p < .05) among them. Each variable had an important role in explaining the data, and all variables should be considered in future studies about the HIU effect on meat quality. Multivariate analysis indicated that beef sonicated at 16–28 W/cm2 for 20–40 min and packed in modified atmosphere had the best physicochemical quality. This study confirmed the efficacy of multivariate statistical techniques in assessing the quality of beef and in indicating the HIU parameters associated with the technological quality of the product.Practical applicationsHIU as an alternative processing technique to conventional methods of beef preservation is considered a green emerging technology. The application of HIU to beef is effective for improving the technological quality of fresh and processed beef. Multivariate data analysis as a complementary discipline in meat processing can generate useful results to make decisions on the equipment design and the application of ultrasound for enhancing the beef technological quality and shelf life, benefiting to the meat industry.
Links between celiac disease and small intestinal bacterial overgrowth: A systematic review and meta‐analysis
Authors: Shah Ayesha , Thite Parag , Hansen Teressa , Kendall Bradley J , Sanders David S , Morrison Mark , Jones Michael P , Holtmann Gerald 
Published: June 2022

AbstractBackground and AimSymptoms of small intestinal bacterial overgrowth (SIBO) and celiac disease (CeD) often overlap, and studies suggest a link between SIBO and CeD. We thus conducted a systematic review and meta‐analysis to compare SIBO prevalence in CeD patients and controls and assessed effects of antimicrobial therapy on gastrointestinal symptoms in SIBO positive CeD patients.MethodsElectronic databases were searched until February 2022 for studies reporting SIBO prevalence in CeD. Prevalence rates, odds ratio (OR), and 95% confidence intervals (CI) of SIBO in CeD and controls were calculated.ResultsWe included 14 studies, with 742 CeD patients and 178 controls. The pooled prevalence of SIBO in CeD was 18.3% (95% CI: 11.4–28.1), with substantial heterogeneity. Including case–control studies with healthy controls, SIBO prevalence in CeD patients was significantly increased (OR 5.1, 95% CI: 2.1–12.4, P = 0.0001), with minimal heterogeneity. Utilizing breath tests, SIBO prevalence in CeD patients was 20.8% (95% CI: 11.9–33.7), almost two‐fold higher compared with culture‐based methods at 12.6% (95% CI: 5.1–28.0), with substantial heterogeneity in both analyses. SIBO prevalence in CeD patients nonresponsive to a gluten free diet (GFD) was not statistically higher as compared with those responsive to GFD (OR 1.5, 95% CI: 0.4–5.0, P = 0.511). Antibiotic therapy of SIBO positive CeD patients resulted in improvement in gastrointestinal symptoms in 95.6% (95% CI: 78.0–99.9) and normalization of breath tests.ConclusionsThis study suggests a link between SIBO and CeD. While SIBO could explain nonresponse to a GFD in CeD, SIBO prevalence is not statistically higher in CeD patients non‐responsive to GFD. The overall quality of the evidence is low, mainly due to substantial “clinical heterogeneity” and the limited sensitivity/specificity of the available diagnostic tests.
Indication of emergency colonoscopy after colorectal endoscopic submucosal dissection: A proposal of hematochezia scale
Authors: Tani Yasuhiro , Kanesaka Takashi , Takeuchi Yoji , Okubo Yuki , Kawakami Yushi , Sakurai Hirohisa , Nakamura Takahiko , Matsueda Katsunori , Miyake Muneaki , Shichijo Satoki , Maekawa Akira , Yamamoto Sachiko , Higashino Koji , Uedo Noriya , Michida Tomoki , Ishihara Ryu 
Published: June 2022

AbstractBackground and AimHematochezia is a major adverse event associated with colorectal endoscopic submucosal dissection (ESD). This study aimed to distinguish between hematochezia that required endoscopic hemostasis and hematochezia that required no hemostasis.MethodsThis retrospective study included consecutive patients who underwent ESD for colorectal tumors at the Osaka International Cancer Institute between September 2017 and August 2020. The exclusion criteria were as follows: patients with coexisting advanced colorectal cancers or inflammatory bowel diseases, patients who received incomplete ESD or emergency surgery, or patients who underwent ESD for multiple lesions. We evaluated whether the patients had hematochezia and underwent emergency colonoscopy and hemostasis during hospitalization. The degree of hematochezia in the saved photographs was assessed using the hematochezia scale and classified as mild, moderate, or severe. Blood pressure, heart rate, time from ESD to first hematochezia, and total number of hematochezia episodes were also evaluated.ResultsAmong the 437 patients who underwent ESD, 44 were excluded, and 393 patients were evaluated. Hematochezia was observed in 100 patients (25%). Emergency colonoscopy was performed in 12 patients (3%), and hemostasis was required in six patients (2%). For patients with hematochezia, only mild hematochezia and hematochezia that developed ≤ 48 h after ESD were significantly associated with no intervention for hemostasis. The positive predictive value for no intervention for hemostasis was 100% (93–100%) for mild hematochezia and 98% (93–100%) for hematochezia ≤ 48 h.ConclusionsMild hematochezia and hematochezia ≤ 48 h were negative predictors of hemostasis, in which emergency colonoscopy may be avoided.
Cognitive impairment, age, quality of life, and treatment strategy for atrial fibrillation in older adults: The SAGE‐AF study
Authors: Karnik Ankur A. , Saczynski Jane S. , Chung Joseph J. , Gurwitz Jerry H. , Bamgbade Benita A. , Paul Tenes J. , Lessard Darleen M. , McManus David D. , Helm Robert H. 
Published: June 2022

AbstractBackgroundAtrial fibrillation (AF) treatment includes anticoagulation for high stroke risk individuals and either rate or rhythm control strategies. We aimed to investigate the impact of age, geriatric factors, and medical comorbidities on choice of rhythm versus rate control strategy in older adults.MethodsPatients with AF aged ≥65 years with CHA2DS2VASc score ≥2 and eligible for anticoagulation were recruited for the Systematic Assessment of Geriatric Elements‐AF (SAGE‐AF) prospective cohort study. An interview that included measures of HRQoL, cognitive function, vision, hearing, and frailty was performed. The association between these elements and AF treatment strategy was examined by multivariable logistic regression models.ResultsOne thousand two hundred forty‐four participants (mean age 76 years; 49% female; 85% non‐Hispanic white) were enrolled. Rate and rhythm control were used in 534 and 710 participants, respectively. Compared to participants <75 years, those ≥75 were more likely to be treated with a rate control strategy (age 75–84 adjusted odds ratio [aOR] 1.37 [95% CI 0.99, 1.88]; age 85+ aOR = 2.05, 95% CI 1.30, 3.21). Those treated with a rate control strategy were more likely to have cognitive impairment (aOR = 1.50, 95% CI 1.13, 1.99), and peripheral vascular disease (PVD) (aOR = 1.82, 95% CI 1.22, 2.72) but less likely to have visual impairment (aOR 0.73 [0.55, 0.98]), congestive heart failure (CHF; aOR 0.68 [0.49, 0.94]) or receive anticoagulation (aOR 0.53, 95% CI 0.36, 0.78).ConclusionOlder age, cognitive impairment, and PVD were associated with use of rate control strategy. Visual impairment, CHF, and anticoagulation use were associated with a rhythm control strategy. There was no difference in HRQoL between the rate and rhythm control groups. This study suggests that certain geriatric elements may be associated with AF treatment strategies. Further study is needed to evaluate how these decisions affect outcomes.
British Dietetic Association consensus guidelines on the nutritional assessment and dietary management of patients with inflammatory bowel disease
Authors: Lomer Miranda C. E. , Wilson Bridgette , Wall Catherine L. 
Published: June 2022

AbstractBackgroundDespite increased awareness of diet and nutrition being integral to the management of patients with inflammatory bowel disease (IBD), there are gaps in the knowledge of IBD healthcare providers regarding nutrition. Furthermore, high quality evidence on nutritional assessment and dietary management of IBD is limited. A Delphi consensus from a panel of experts allows for best‐practice guidelines to be developed, especially where high quality evidence is limited. The aim was to develop guidelines for the nutritional assessment and dietary management of IBD using an eDelphi online consensus agreement platform.MethodsSeventeen research topics related to IBD and nutrition were systematically reviewed. Searches in Cochrane, Embase®, Medline® and Scopus® electronic databases were performed. GRADE was used to develop recommendations. Experts from the IBD community (healthcare professionals and patients with IBD) were invited to vote anonymously on the recommendations in a custom‐built online platform. Three rounds of voting were carried out with updated iterations of the recommendations and evaluative text based on feedback from the previous round.ResultsFrom 23,824 non‐duplicated papers, 167 were critically appraised. Fifty‐five participants completed three rounds of voting and 14 GRADE statements and 42 practice statements achieved 80% consensus. Comprehensive guidance related to nutrition assessment, nutrition screening and dietary management is provided.ConclusionsGuidelines on the nutritional assessment and dietary management of IBD have been developed using evidence‐based consensus to improve equality of care. The statements and practice statements developed demonstrate the level of agreement and the quality and strength of the guidelines.
Field‐based versus laboratory‐based estimates of muscle quality index in adolescents with and without Down syndrome
Authors: Melo G. L. R. , Moraes M. R. , Nascimento E. F. , Boato E. M. , Beal F. L. R. , Stone W. , da Cunha Nascimento D. 
Published: June 2022

AbstractBackgroundLow muscle quality index (MQI) is a potential risk of developing functional impairments in older people. However, considering that individuals with Down syndrome (DS) present with a faster decline in biological aging, an investigation on MQI in individuals with DS is necessary. The aims of this present cross‐sectional study were to compare (1) MQI between adolescents with and without DS and (2) evaluate laboratory versus field‐based estimates of MQI.MethodsFifty‐six adolescents were recruited and separated into two groups: DS (n = 30, 13 boys and 17 girls; age: 12.38 ± 3.07 years) and a control (non‐DS; n = 26, 9 boys and 17 girls; age: 12.46 ± 2.88 years). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual‐energy X‐ray absorptiometry (DXA). Field‐based MQI was quantified from the ratio of hand grip strength (HGS) to body mass index (BMI). For statistical analyses, a two‐way ANOVA was conducted for group comparisons, and a Pearson correlation was used to test the association between field MQI and laboratory MQI.ResultsAdolescents with DS displayed lower field (P = 0.001), laboratory MQI estimates (P = 0.001) and HGS (P = 0.001) as compared non‐DS. Also, there was a strong correlation effect between field MQI and laboratory MQI estimates (P < 0.001, R = 0.81).ConclusionAdolescents with DS have lower field and laboratory MQI compared with adolescents without DS. Simpler field MQI might be used in daily clinical practice, with special attention to those with DS.
Living with parental mental illness is like a roller coaster: Reflections on children's lifeworld in the family setting
Authors: Cudjoe Ebenezer , Tam Cherry Hau Lin , Effah Deborah , Amegashie Elorm Faith , Tweneboah Adjoa Owusu 
Published: June 2022

AbstractAims and objectivesTo explore what it is like for children in the family setting to live with parental mental illness.BackgroundThere are reported risks of negative social and behavioural outcomes among children living with parental mental illness such as poor school performance, isolation and poor mental health. There is yet more to know about how children's interactions with significant members of the family shape their experiences.DesignA phenomenological design following Husserl's concepts of lifeworld and inter‐subjectivity was adapted for the study.MethodTwenty‐one children (ages 10–17) who lived with a parent with mental illness were interviewed. The data were analysed to attain the essential features of the phenomenon. The study followed the COREQ checklist for qualitative studies.FindingsThe essence of the phenomenon ‘living with parental mental illness’ in the family setting comprises strain, sadness and some happy moments. Living with parental mental illness can produce unpredictable life situations for children as relationships and interactions in the family setting can be chaotic and confusing. The ups and downs define their lifeworld as a roller coaster. Strenuous family environment, sibling interaction, navigating separate living arrangements and there are good days were specific themes that clarified the children's lives as a roller coaster.ConclusionA concept called the ‘parent paradox’ is coined to reflect how children are torn between what their living situation looks like comparing the parent with mental illness and the other without mental illness. The paradox is founded on children's loyalty towards their parents.Relevance to clinical practiceTo break the unhealthy cycle created by the parent paradox, mental health nurses should ensure that children are well informed about the parent's mental condition including information about treatment procedures and recovery. Child's psychological distress may be reduced when they are informed.
Genetic polymorphisms in DNA repair genes and their association with risk of cervical cancer: A systematic review and meta‐analysis
Authors: Shao Xueting , Yang Xiaole , Liu Ying , Song Qingxia , Pan Xin , Chen Wansu , Jiang Wei , Xu Dan , Song Yuanyuan , Chen Renshou 
Published: June 2022

AbstractBackgroundThere have been a large number of epidemiologic studies regarding the association between genetic polymorphisms in DNA repair genes and onset of cervical cancer. However, results are inconsistent.MethodsArticles published before June 2021 and regarding genetic polymorphisms in DNA repair genes and cervical cancer were searched in following databases: PubMed, Web of Science, Google Scholar, and CNKI. With at least three articles for each polymorphism, we made meta‐analysis to compute multivariate odds ratios (ORs) and their 95% confidence intervals (CIs).ResultsThe present study showed significant associations between XRCC1 Arg399Gln polymorphisms and risk of cervical cancer in Asian, whereas no significant association between them were showed in Caucasian (Asian: GA vs. GG: OR = 1.27, 95%CI 1.06–1.52; AA vs. GG: OR = 1.91, 95%CI 1.29–2.83; GA + AA vs. GG: OR = 1.36, 95%CI 1.12–1.65; AA vs. GG + GA: OR = 1.66, 95%CI 1.17–2.37; Caucasian: GA vs. GG: OR = 1.08, 95%CI 0.83–1.41; AA vs. GG: OR = 2.18, 95%CI 0.75–6.31; GA + AA vs. GG: OR = 1.23, 95%CI 0.85–1.78; AA vs. GG + GA: OR = 1.70, 95%CI 0.69–4.18). In addition, there were significant associations between ERCC2 rs13181 polymorphisms and risk of cervical cancer in Asian (AC vs AA: OR = 0.53, 95%CI 0.37–0.75, I2 = 0.0%, p value of Q test = 0.847; AC + CC vs AA: OR = 0.50, 95%CI 0.36–0.70, I2 = 0.0%, p value of Q test = 0.856).ConclusionsThe meta‐analysis showed that there were significant associations between XRCC1 Arg399Gln and ERCC2 rs13181 polymorphisms and risk of cervical cancer.
Potential and promising marker for serious bacterial infections in children: Delta neutrophil index
Authors: Yigit Metin , Ozkaya‐Parlakay Aslinur , Yilmaz Naci , Akyol Ozhan , Gulhan Belgin , Kanik Yuksek Saliha , Yalcin Burhan Basak , Kilic Enes K , Karagol Cuneyt 
Published: June 2022

AimThis study aimed to evaluate the usefulness and accuracy of the delta neutrophil index (DNI), an index expressing the number of immature granulocytes as a proportion of the total, as an inflammatory marker in predicting serious bacterial infections (SBIs).MethodsPaediatric patients admitted to our hospital with fever were divided into four groups: SBI, non‐SBI, COVID‐19 and control group. White blood cell count, absolute neutrophil count, C‐reactive protein and the DNI were recorded, and their accuracy in predicting SBI was evaluated.ResultsMean DNI was 4.96 ± 8.38 in the SBI group (150 patients), 0.67 ± 1.68 in the non‐SBI group (397 patients), 0.29 ± 0.99 in the COVID‐19 group (112 patients) and 0.14 ± 0.21 in the control group (102 patients). The DNI was significantly higher in the SBI group compared with the non‐SBI (P < 0.001); the non‐SBI group also had higher levels than the COVID‐19 group (P = 0.005). One percent increase in the DNI increased the SBI rate 1.36 times (odds ratio 1.36 (95% confidence interval 1.23–1.49), P < 0.001). Based on the determined cut‐off value (>2.5%), the DNI (odds ratio 6.27 (95% confidence interval 3.85–10.21), P < 0.001) significantly predicted SBIs with 90.4% specificity and 47.7% sensitivity.ConclusionsSBIs in childrenare associated with an increase in DNI levels. Compared to other biomarkers, the DNI had higher specificity in predicting SBIs. The DNI may also be usefulin differentiating bacterial and non‐bacterial infections in individualclinical syndromes. Currently, there is no evidence that serum DNI aids indifferentiating COVID‐19 and upper respiratory tract infection.
Effects of peer‐delivered self‐management, recovery education interventions for individuals with severe and enduring mental health challenges: A meta‐analysis
Authors: Peck Celia Kim Huey , Thangavelu Dhivya Prabha , Li Ziqiang , Goh Yong Shian 
Published: June 2022

Accessible SummaryWhat is known on the subject?

The paradigm shifts in the conceptualization of recovery have led to a wide adoption of peer‐delivered self‐management interventions among individuals with severe and enduring mental health challenges.

Peers with experiential knowledge on managing their own mental health conditions act as role models for affected individuals.

What the paper adds to existing knowledge?

The meta‐analysis demonstrated significant small‐to‐medium effects favouring such interventions on symptom severity, self‐perceived recovery, hopefulness and empowerment.

What are the implications for practice?

With peer‐delivered self‐management interventions, individuals with severe and enduring mental health challenges could self‐direct their care, thus reducing their reliance on service providers.

Individuals with severe and enduring mental health challenges equipped to seek their recovery within the community beyond institutional care, regaining independence and gradually reintegrate into society.

AbstractIntroductionThe shift in mindset within mental health care has led to the adoption of peer‐delivered self‐management interventions in promoting recovery among individuals with severe and enduring mental health challenges. However, no reviews have hitherto examined their effectiveness.AimTo determine the effectiveness of peer‐delivered self‐management interventions in improving symptom severity, self‐perceived recovery, hopefulness and empowerment.MethodA search was performed in nine English databases for published studies and grey literature from inception to the 5 January 2021. The methodological quality of the studies was graded with the Joanna Briggs Institute's critical appraisal tools. The overall effects were pooled through a meta‐analysis with heterogeneity evaluated via the chi‐square test and I‐square statistics. This review was guided by the PRISMA 2020 statement on transparent reporting of systematic review and meta‐analyses.ResultsSeventeen publications involving 3189 participants were included in this review, and ten were included for the meta‐analysis and accounted for 2725 participants. The meta‐analysis demonstrated significant small‐to‐medium effects favouring such interventions on symptom severity, self‐perceived recovery, hopefulness and empowerment.DiscussionPeer‐delivered self‐management interventions should be implemented as it is effective in promoting recovery among individuals with severe and enduring mental health challenges.Implications for practiceWith peer‐delivered self‐management interventions, individuals with severe and enduring mental health challenges could self‐direct their care and reduce their reliance on service providers.