bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrapleural infusion of tumor cell-derived microparticles packaging methotrexate or saline combined with pemetrexed-cisplatin chemotherapy for the treatment of malignant pleural effusion in advanced non-squamous non-small cell lung cancer: A double-blind, randomized, placebo-controlled study
Authors: Dong Xiaorong , Huang Yu , Yi Tienan , Hu Chunhong , Gao Quanli , Chen Yuan , Zhang Jing , Chen Jianhua , Liu Li , Meng Rui , Zhang Sheng , Dai Xiaofang , Fei Shihong , Jin Yang , Yin Ping , Hu Yanping , Wu Gang 
Published: October 2022

BackgroundPreclincal studies showed the promising efficacy of tumor cell-derived microparticles packaging methotrexate (TMPs-MTX) to treat advanced non-squamous non-small cell lung cancer (NSCLC) with malignant pleural effusion (MPE).MethodsThis randomized, double-blind, placebo-controlled study was conducted at six hospitals in China from 20 July 2015 to 25 April 2019. Patients newly diagnosed with non-squamous NSCLC with MPE were randomly assigned to receive TMPs-MTX (group A) or saline (group B). Patients in both groups received pemetrexed (500 mg/m2 d1) and cisplatin (75 mg/m2 in total for d1-d2). Intrapleural infusion (50 mL saline containing 5 units of TMPs-MTX per perfusion, once every 48 hours, six total perfusions) was initiated on day 5 after pemetrexed-cisplatin chemotherapy. The primary outcome was the objective response rate (ORR) of MPE. Secondary outcomes included the ORR of target lesions, progression-free survival (PFS), overall survival (OS), toxicity, and pleural fluid properties.ResultsA total of 86 patients were enrolled in this study and randomly assigned to either group A or group B. Of these, 79 patients were evaluable for response. The ORR of MPE in group A was significantly higher than that in group B (82.50% vs. 58.97%, P = 0.0237). The ORR of target lesions was 25.64% in group A and 20.51% in group B (P = 0.5909), respectively. With a median follow-up time of 18.8 months, median PFS were 6.4 (95% CI, 4.5-12.3) months in group A and 7.3 (95% CI, 6.1-10.4) months in group B (P = 0.6893), and median OS were 19.9 (95% CI, 17.1-28.5) months and 17.5 (95% CI, 11.6-25.0) months (P = 0.4500), respectively. The incidence rates of adverse events were similar in the two groups. The most common treatment-related adverse events were chemotherapy-induced toxicities, including fever, gastrointestinal reactions, hepatic dysfunction, and leukopenia.ConclusionIntrapleural infusion of TMPs-MTX combined with pemetrexed-cisplatin chemotherapy is safe and effective against MPE in patients with advanced non-squamous NSCLC.Clinical trial registrationhttp://www.chictr.org.cn (ChiCTR-ICR-15006304).
Effect of acupuncture for disorders of consciousness in patients with stroke: A systematic review and meta-analysis
Authors: Huang Zhibin , Chen Yuning , Xiao Qilan , Kuang Weichuan , Liu Kun , Jiang Ye , Wen Xi , Qin Weiting , Liu Yue , Liu Tong 
Published: October 2022

BackgroundDisorder of consciousness (DOC) is frequent in patients with stroke, which is the second most common cause of death and a leading cause of disability. Acupuncture has been used as a curative method for DOC treatment in China. Nevertheless, no critical systematic review of acupuncture's effect on DOC has been published. This review aims to evaluate the present evidence regarding the efficacy of acupuncture for DOC after stroke.MethodsSeven databases were searched from their inception to November 1, 2021, containing three English databases (PubMed, Embase, and Cochrane Central Register of Controlled Trials) and four Chinese databases (CNKI, CBM, VIP, and Wanfang Database). The primary outcomes comprise the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) before and after treatment. Secondary outcomes involve resuscitation rate, resuscitation time, and adverse events. Data synthesis was calculated by RevMan (V.5.4.1) software. According to the Cochrane Handbook, methodological quality was assessed with the risk of bias tool 2.0 (RoB2).ResultsSeventeen studies containing 1,208 patients were eventually included in our review. Overall, most trials were rated as high or had some concerns regarding the risk of bias. GCS was reported in 16 trials, and a meta-analysis showed that GCS improvement in the acupuncture group was greater than in the non-acupuncture group (MD 1.45, 95% CI 0.94–1.97, P &lt; 0.0001). One trial reported that GOS improvement in the acupuncture plus medication group was greater than in the medication group (MD 0.58, 95% CI 0.11–1.05, P = 0.01). Another study reported that acupuncture plus medication was statistically more effective in shortening resuscitation time than medication alone (MD−0.89, 95% CI −1.53 to −0.25, P = 0.006). Four trials reported that the resuscitation rate in the acupuncture group was higher than without acupuncture intervention (RR 1.68, 95% CI 1.30–2.18, I2 0%, P = 0.39). Adverse events were reported in two studies, with one case in the acupuncture group suffering from subcutaneous hematoma.ConclusionAcupuncture may improve consciousness level, increase the resuscitation rate, and shorten resuscitation time for post-stroke patients with DOC. Adverse events from acupuncture were rare, tolerable, and recoverable. However, the results should be interpreted cautiously, and more rigorous RCTs with better methodology are warranted.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=289802, identifier 289802.
Decreased locus coeruleus signal associated with Alzheimer’s disease based on neuromelanin-sensitive magnetic resonance imaging technique
Authors: Li Meng , Liu Shanwen , Zhu Hongqin , Guo Zhiwen , Zhi Yuqi , Liu Rong , Jiang Zhen , Liang Xiaoyun , Hu Hua , Zhu Jiangtao 
Published: October 2022

ObjectiveNeuromelanin-sensitive magnetic resonance imaging (NM-MRI) technique was used to detect the changes of the locus coeruleus (LC) signals in Alzheimer’s disease patients (AD), and to analyze its correlation with cognitive function.Materials and methodsA total of 27 patients with AD, 15 patients with mild cognitive impairment (MCI), and 25 healthy controls (HC) were examined by NM-MRI technique. ImageJ software was used to measure the LC signals. The locus coeruleus signal contrast ratios (LC-CRs) were calculated, along with the measurement of neuropsychological scales.ResultsThe LC-CRs of AD patients were significantly different from that of HC (p = 0.007, 95% CI: −0.053∼−0.007). However, such significant differences were not observed between MCI and HC (p = 1.000, 95% CI: −0.030∼0.024), AD and MCI (p = 0.050, 95% CI: −0.054∼0.000). Furthermore, a significant positive correlation was identified between LC-CRs and MMSE sub item Drawing (r = 0.484, p = 0.011) in the AD group, MoCA sub item Attention (r = 0.519, p = 0.047) in the MCI group. The area under the curve of LC-CRs in the diagnosis of AD was 0.749 (p = 0.002, 95% CI: 0.618∼0.880), with a sensitivity of 85.2% and a specificity of 56.0%.ConclusionThe NM-MRI technique could quantify the pathological degenerations of the LC in AD. Such LC degenerations can be employed to distinguish AD from healthy elderly.
Neural activity during processing Chinese irony text: An event-related potential study
Authors: Shi Hanwen , Li Yutong 
Published: October 2022

ObjectiveIrony as an indirect language with unpredictability consumes more cognitive resources, and is more difficult to understand than literal language. This study aims to explore the processing differences between irony and literal sentences using event-related potential (ERP) technology.Materials and methodsThree types of sentences were involved: sentences with predictable literal meaning, sentences with unpredictable literal meaning, and sentences with ironic meaning. The neural responses of the subjects were recorded when they read sentences.ResultsCompared to predictable literal meaning sentences, unpredictable literal meaning sentences and ironic meaning sentences elicited larger amplitude of N400 components. The difference was not significant between the latter two. In addition, there was no significant difference in P600 evoked by the three sentences.ConclusionIn the initial stage of irony processing, the low predictability may result in the difficulty in semantic comprehension, in which the processing patterns of unpredictable and ironic sentences are rather close. In the later stage of processing, ironic integration is not harder compared to literal sentence integration.
Prevalence, knowledge and attitude toward electronic cigarette use among male health colleges students in Saudi Arabia—A cross-sectional study
Authors: Alsanea Sary , Alrabiah Ziyad , Samreen Sana , Syed Wajid , Bin Khunayn Rawan M. , Al-Arifi Nasser M. , Alenazi Miteb , Alghadeer Sultan , Alhossan Abdulaziz , Alwhaibi Abdulrahman , Al-Arifi Mohamed N. 
Published: October 2022

BackgroundHealth care professionals have an important role in increasing awareness about smoking harms and serving as role models. This study aims to assess knowledge, attitude and perception toward electronic cigarettes (ECs) as well as prevalence of ECs use among male health colleges students.MethodThis is a cross-sectional survey-based study conducted among students in the male campus of five different health colleges over a 4-month period from February 2020 to May 2020. Descriptive analysis was used to assess the knowledge, perception and attitude, and inferential testing was used to evaluate the association of different participant's variables and knowledge toward ECs usage using SPSS.ResultsA total of 333 students were included in the analysis. Most of students (n = 205; 61.6%) had never used ECs, while 22.8 and 15.6% used them for recreational and smoking cessation purposes, respectively. Focusing on ECs users from each college individually, medical students had the highest prevalence followed by dental, pharmacy and nursing students (47.4, 40.7, 34.5, and 32%, respectively). Many students had misconceptions and a low level of knowledge about ECs, such as recognizing them as smoking-cessation tools and not knowing whether toxic and carcinogenic components levels in ECs are similar to conventional cigarettes, respectively. Medical students had significantly higher knowledge compared to dental students [3 (2) vs. 2 (1); p = 0.033]. Moreover, smokers were less knowledgeable than non-smokers [2.5 (1) vs. 2.1 (1), p = 0.027]. At least 62.8% of students perceived using ECs as a fashionable alternative smoking method and 59.2% believed that they may become a gateway for smoking addiction. Only 120 (36.0%) health colleges students were confidently able to advise smokers regarding ECs.ConclusionOur study highlights an increased trend of ECs use accompanied with insufficient knowledge and several misconceptions about ECs among health colleges students. This was associated with a negative influence on their attitude toward ECs use, which would potentially lead to negative consequences on public health.
Body mass index and quality of life in individuals with polycystic ovary syndrome: Dysmorphic concerns and eating disorders as mediators
Authors: Barberis Nadia , Calaresi Danilo , Cannavò Marco , Verrastro Valeria 
Published: October 2022

ObjectiveWeight issues, dysmorphic concerns and eating disorders are common among individuals with polycystic ovary syndrome (PCOS) and are linked to poor quality of life (QoL). The goal of the current study was to examine whether the association between body mass index (BMI) and QoL was mediated by dysmorphic concerns, examining also the relations with eating disorder symptomatology.MethodsQuestionnaires were administered to 435 individuals with PCOS aged between 18 and 40 years (M = 27.62; SD = 4.83) to measure dysmorphic concerns, eating disorder symptoms and QoL. Participants were also asked to report their height and weight to compute their BMI.ResultsStructural equation modeling was used to observe the relationship between the variables. The results revealed a direct relationship between QoL, BMI, dysmorphic concerns and eating disorder symptomatology. In addition, dysmorphic concerns were related to BMI and eating disorder symptomatology. Furthermore, the results showed the mediating role of dysmorphic concerns and eating disorder symptoms in the relationship between BMI and QoL.ConclusionThe current results highlight the potential importance of harmful relationships with one's own body and food, explaining why weight issues may be linked to different levels of QoL in PCOS individuals. The implications of these findings are discussed.
Analisis performansi high availability cluster server menggunakan heartbeat pada private cloud
Authors: Iryani Nanda , Ayatri Kholifah Dyah , Wahyuningrum Reni Dyah 
Published: October 2022

Pada era new normal terjadinya peningkatan penggunaan internet, sehingga membuat web server akan terus menerus bekerja tanpa berhenti. Semakin tinggi sebuah permintaan pada web server maka beban web server akan semakin bertambah dan server akan mengalami down. Solusinya adalah dengan adanya server yang mempunyai kehandalan dan mampu mengatasi masalahnya sendiri. Jika menggunakan sebuah server saja tidak dapat disebut handal dikarenakan jika server tersebut mati maka sistem akan mati dan tidak dapat melayani sebuah permintaan tanpa adanya server cadangan. Solusinya adalah dengan menerapkan high availability dengan metode heartbeat untuk memastikan failover clustering disaat server utama mati maka akan digantikan dengan server cadangan. Heartbeat dibangun dalam beberapa web server yang terpasang pada private cloud. Private cloud digunakan karena memiliki banyak manfaat seperti kendali penuh dapat menyesuaikan penggunaan sumber daya dengan kebutuhan server dengan lebih baik. Faktor penelitian berdasarkan dari nilai downtime dan nilai availability yang menjadikan sebuah parameter server cluster dapat berjalan dengan baik. Pengujian dilakukan melalui 5 variasi jumlah koneksi, yaitu 200 koneksi, 400 koneksi, 600 koneksi, 800 koneksi, dan 1000 koneksi dengan laju 100 permintaan/detik. Hasil pengujian menunjukkan nilai rata-rata throughput semua variasi sebesar 5,254 Mbit/s dengan tertinggi pada 600 koneksi yaitu 6,233 Mbit/s. Delay menunjukkan kategori Sangat Baik berdasarkan standarisasi TIPHON yaitu kurang dari 150 ms. Presentasi packet loss juga menunjukkan kategori Sangat Baik hingga 1000 koneksi semua paket diloloskan. Hasil pengujian menunjukkan bahwa High Availability Cluster Server menggunakan Heartbeat pada private cloud menunjukan hasil yang sangat baik dimana sistem masih optimal hingga beban 1000 koneksi.
Prevalence and distribution of rice blast disease in different rice ecosystems of Karnataka, India
Authors: Chittaragi Amoghavarsha , Naik Ganesha R , Pramesh Devanna , Naik Manjunatha K , A Raghunandana , E Chidanandappa , Huded Sharanabasav , Alase Saddamhusen , BS Chethana 
Published: October 2022

Rice is the most widely consumed cereal staple food for a significant part of the world, particularly in Asia. The Karnataka state of India is one of the highest rice producers, and it has a varied rice ecosystem from irrigated plains to rainfed hilly areas. The rice blast occurs at different severity in these ecosystems causing significant losses each year. The roving survey was carried out in the 120 villages of 18 districts distributed under five irrigated and two rainfed ecosystems of Karnataka during Kharif -2019. Within the irrigated ecosystems, the highest PDI was observed in the Kavery (50.85), followed by Varada (45.89), Bhadra (45.82), Tungabhadra (11.13), and Upper Krishna (10.58) command areas. In a rainfed ecosystem, the highest PDI was observed in the hilly ecosystem (53.38) and the least in the coastal ecosystem (3.73). Within 18 districts, the lowest PDI was observed in the Gadag district (1.68) of the Thungabhadra ecosystem, and the highest was observed in the Chikkamagalur district (81.60) of the hilly ecosystem. The disease was severe in the rainfed hilly ecosystem, followed by an irrigated and rainfed coastal ecosystem. This information is helpful in formulating the management strategies of rice blast in different rice ecosystems of Karnataka.
Pyrometallurgy and Electrometallurgy of Rare Earths – Part B: Cell design, construction, rate processes, and unit operation
Authors: Rafique Muhammad Musaddique Ali 
Published: October 2022

<p>Present study consititutes researching extraction and refining of rare earths. A quantitative approach is adopted enlisting and enumerating equations, diagrams and graphs. Emphasis is placed on arriving at definitive answer regarding assumed hypothesis. </p>
Patch-wise 3D Segmentation Quality Assessment Combining Reconstruction and Regression Networks
Authors: Zaman Fahim Ahmed , Roy Tarun Kanti , Sonka Milan , Wu Xiaodong 
Published: October 2022

<p>In this article, we propose a novel deep learning framework to identify location-specific inaccurate segmentation for medical images to aid downstream analyses. The proposed method relies directly on the extracted segmentation related features and does not need to use the independent standard during the inference phase to identify erroneous regions in the computed segmentation. This is significant because image segmentation plays an indispensable role for automated quantitative analysis in modern precision medicine and the absence of case-by-case ground truth for medical images limits the segmentation quality assessment. Moreover, in contrast to our approach, to the best of our knowledge, current deep learning-based segmentation quality assessment models evaluate the segmentation quality globally and may ignore significant local segmentation errors in locations where diseases are prevalent. For the purpose of disease diagnosis and/or prognosis, it is critical to identify inaccurate segmentation in local regions. We used two publicly available datasets to evaluate our method and show that our method is robust and works well to localize small but significant inaccurate segmentation in the cases of both good and bad overall segmentation results for different imaging modalities. </p>
PSYCHOLOGICAL WELL-BEING PADA WANITA YANG MENIKAH DENGAN PROSES TA’ARUF
Authors: Lusi Anggraini Siagian  
Published: October 2022

Penelitian ini bertujuan untuk mengetahui bagaimana Psychological well-being ataukesejahteraan psikologis pada pasangan yang ta’aruf. Penelitian ini menggunkan metodefenomologi dengan tekinik pengumpulan data menggunakan metode wawancara dan observasi.Sumber data informan penelitian ini terdiri dari lima orang subjek penelitian dan lima oranginforman penelitian. Subjek penelitian merupakan wanita yang menikah dengan proses ta’aruf.Pemilihan subjek menggunakan teknik purposive sampling. Hasil penelitian menunjukkan subjekyang menikah dengan proses ta’aruf bahagia dengan kehidupan pernikahanna, subjek merasa aman,nyaman dan sejahtera psikologisnya dalam menjalani kehidupan pernikahan. Kelima subjek bahagiadalam menjalani kehidupan pernikahannya karena subjek menikah dengan niat ibadah. Pasanganpernikahan hasil ta’aruf mempunyai perilaku bahwa pernikahan adalah sarana untuk meningkatkanketaatan kepada Tuhan, artinya interaksi yang dibangun bukan hanya atas dasar melaksanakan hakdan kewajiban kepada pasangan namun itu juga bentuk ketaatan kepada Tuhan, bukan hanyasekedar bersatu dan diikat oleh kata pernikahan saja, namun ada tuntutan hak, kewajiban dantanggung jawab yang harus diemban, tidak hanya dipertanggung jawabkan ke suami atau istri tetapijuga kepada Tuhan.Kata Kunci: Psychological well-being, ta’aruf
This study aims to determine how the psychological well-being or psychological wellbeingof ta'aruf couples. This study uses a phenomology method with data collection techniquesusing interviews and observations. The data sources of this research informant consisted of fiveresearch subjects and five research informants. The research subjects are women who are marriedwith the ta'aruf process. Subject selection using purposive sampling technique. The results showedthat subjects who were married with the ta'aruf process were happy with their married life, thesubject felt safe, comfortable and psychologically prosperous in living their married life. The fivesubjects are happy in living their married life because the subject is married with the intention ofworship. Ta'aruf marriage couples have the behavior that marriage is a means to increase obedienceto God, not an interaction that is built on the basis of carrying out rights and obligations to a partnerbut also a form of obedience to God, not just gathering by the word marriage, but there aredemands, obligations and responsibilities that must be carried out, are not only accountable to thehusband or wife but also to God.Keywords: Psychological well-being, ta’aruf
ЦИФРОВІЗАЦІЯ ПУБЛІЧНОГО УПРАВЛІННЯ ТА Е-ДЕМОКРАТІЇ НА РЕГІОНАЛЬНОМУ РІВНІ
Authors: Пиріг Світлана  
Published: October 2022

У статті узагальнено питання цифровізації публічного управління та е-демократії, що є процесом зміни управління загалом та діяльності державних органів зокрема, що базується на цифрових технологіях у процесі надання державних послуг. Основною метою дослідження є визначення основних переваг е-демократії, що спонукають зростанню можливостей громадян щодо їх участі в суспільно-політичному управлінні та інструментів електронної демократії, що стали зручними онлайн-інструментами комунікації громадян, організацій громадянського суспільства з органами виконавчої влади. Систематизація літературних джерел та підходів до вирішення проблеми цифровізації публічного управління та е-демократії на регіональному рівні свідчить про те, що даний процес вимагає постійного впровадження і вдосконалення цифрових інструментів електронної демократії з метою створення цифрової держави, що орієнтована на задоволення потреб громадян. Актуальність вирішення даної наукової проблеми полягає в тому, що розвиток цифровізації публічного управління та електронної демократії на регіональному рівні залежить від доступності до цифрових технологій та активності громадян використання платформи «е-ВзаємоДії». Дослідження теми цифровізації публічного управління та електронної демократії на регіональному рівні у роботі здійснюється в такій логічній послідовності: визначено актуальність побудови системи електронного урядування та електронної взаємодії, що позитивно впливає на подальші перетворення в державі, насамперед, методи та форми взаємодії органів державного управління з населенням та бізнесом; громадськими організаціями; досліджено переваги використання е-демократії, що позитивно впливають на подальші радикальні перетворення в цифровому суспільстві. Методологічним інструментарієм методів дослідження були кілька останніх років досліджень. Об’єктом дослідження є процеси, що пов’язані з поширенням електронної демократії на регіональному рівні, які впливають на цифровий розвиток публічного управління та цифрової держави. У статті представлені результати емпіричного аналізу кількості органів виконавчої влади, які надавали можливість використання інструментів е-демократії, що дало змогу Україні увійти до групи країн з високим рівнем електронного урядування. Дослідження емпірично підтверджує та теоретично доводить, що розвиток е-демократії є важливим кроком Уряду до створення сервісної держави, яка орієнтована на задоволення потреб громадян для комунікації та взаємодії з органами виконавчої влади. Результати дослідження можуть бути корисними для науковців та практиків, що займаються дослідженням цифрового розвитку та е-домократії в Україні.