bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferromagnetic Flexible Electronics for Brain‐Wide Selective Neural Recording
Authors: Liu Yuxin , Chen Xi , Liang Ye , Song Hao , Yu Peng , Guan Shunmin , Liu Zijian , Yang Anqi , Tang Minghui , Zhou Yajing , Zheng Ying , Yang Zhilun , Jiang Lelun , He Jufang , Tan Ning , Xu Bingzhe , Lin Xudong 
Published: December 2022

AbstractFlexible microelectronics capable of straightforward implantation, remotely controlled navigation, and stable long‐term recording hold great promise in diverse medical applications, particularly in deciphering complex functions of neural circuits in the brain. Existing flexible electronics, however, are often limited in bending and buckling during implantation, and unable to access a large brain region. Here, an injectable class of electronics with stable recording, omnidirectional steering, and precise navigating capabilities based on magnetic actuation is presented. After simple transcriptional injection, the rigid coatings are biodegraded quickly and the bundles of magnetic‐nanoparticles‐coated microelectrodes become separated, ultra‐flexible, and magnetic actuated for further minimally invasive three‐dimensional interpenetration in the brain. As proof of concept, this paradigm‐shifting approach is demonstrated for selective and multiplexed neural activities recording across distant regions in the deep rodent brains. Coupling with optogenetic neural stimulation, the unique capabilities of this platform in electrophysiological readouts of projection dynamics in vivo are also demonstrated. The ability of these miniaturized, remotely controllable, and biocompatible ferromagnetic flexible electronics to afford minimally invasive manipulations in the soft tissues of the mammalian brain foreshadows applications in other organ systems, with great potential for broad utility in biomedical science and engineering.
Highly Efficient Decoupled Triple‐Channel OAM Generation with a Single‐Layer Shared Aperture Reflective Metasurface
Authors: Jiang Yuying , Liu Liangliang , Li Shuying , Tang Chunzi , Luo Zhengzhi , Zhu Zhengtao , Cao Yuxiang , Gu Changqing , Li Zhuo 
Published: December 2022

AbstractMetasurface is extensively studied for generating multicharacteristic orbital angular momentum (OAM) beams. However, designing a highly integrated and independent polarization‐frequency multiplexing metasurface for efficient multiscenario OAM‐related applications is still a challenge. Here, a triple‐band single‐layer shared aperture reflective metasurface for triple‐polarization channels independent OAM modulations is proposed. The specific frequency quantitative customization resonance phase and quasi‐static geometric phase are utilized to manipulate the dual‐band (Ku‐ and K‐band) orthogonal linearly polarized (LP) channel and C&X‐band right‐handed circularly polarized (RHCP) channel. An isolation ring is introduced for eliminating the strong coupling between the structurally compatible RHCP and orthogonal‐LP subunits in a shared aperture meta‐atom. It is revealed that the isolation ring not only helps realize efficient multipolarization, multiband, and multimode OAM generation, but also expands the operation bandwidth of the RHCP channel OAM. A proof‐of‐concept prototype of the designed metasurface is constructed to verify the methodology and the experimental results are in excellent agreement with simulations. The proposed independent OAM modulation scheme for extending the functionality of metasurface offers a novel route to realize multipolarization and multiband OAM beams with high isolation, which may have potential applications in OAM‐based multichannel multiplexing communications.
Organocatalytic oxa‐Michael/Michael Addition/Deformylation Cascade Reaction of 3‐Formylchromone with p‐Quinol: Synthesis of the Furanochromanone Skeleton
Authors: Zheng Xiurong , Chen Jiajia , Li Zhuowen , Zhong Lin , Zhan Ruoting , Huang Huicai 
Published: December 2022

AbstractAn approach for the construction of furanochromanone skeletons has been developed through a DABCO‐catalyzed cascade reaction with good yields (up to 83%) and high diastereoselectivity (>20:1 dr). Notably, the asymmetric catalytic version of this reaction was further studied, obtaining furanochromanones bearing four contiguous stereogenic centers with excellent enantio‐ and diastereoselectivity (up to 98% ee, >20:1 dr). This protocol causes the formation of a variety of substituted furanochromanones via an oxa‐Michael/Michael addition/deformylation cascade reaction.magnified image
Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis
Authors: Niu Ningning , Shen Xuqing , Zhang Li , Chen Yueyue , Lu Ping , Yang Wenjuan , Liu Mingzhu , Shi Juanjuan , Xu Dapeng , Tang Yingying , Yang Xiaotong , Weng Yawen , Zhao Xinxin , Wu Lian‐Ming , Sun Yongwei , Xue Jing 
Published: December 2022

AbstractGenetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigenesis. However, little is known about its role in remodeling the TME and immune evasion. Here, it is shown that SETD2 deficiency can reprogram neutrophils to an immunosuppressive phenotype, thereby promoting immune escape during pancreatic tumor progression. By comprehensive profiling of the intratumoral immune cells, neutrophils are identified as the subset with the most significant changes upon Setd2 loss. Setd2‐deficient pancreatic tumor cells directly enhance neutrophil recruitment and reprogramming, thereby inhibiting the cytotoxicity of CD8+ T cells to foster tumor progression. Mechanistically, it is revealed that Setd2‐H3K36me3 loss leads to ectopic gain of H3K27me3 to downregulate Cxadr expression, which boosts the PI3K‐AKT pathway and excessive expression of CXCL1 and GM‐CSF, thereby promoting neutrophil recruitment and reprogramming toward an immunosuppressive phenotype. The study provides mechanistic insights into how tumor cell‐intrinsic Setd2 deficiency strengthens the immune escape during pancreatic tumorigenesis, which may offer potential therapeutic implications for pancreatic cancer patients with SETD2 deficiency.
3D Gelatin Microsphere Scaffolds Promote Functional Recovery after Spinal Cord Hemisection in Rats
Authors: Ke Hongfei , Yang Hongru , Zhao Yijing , Li Tingting , Xin Danqing , Gai Chengcheng , Jiang Zige , Wang Zhen 
Published: December 2022

AbstractSpinal cord injury (SCI) damages signal connections and conductions, with the result that neuronal circuits are disrupted leading to neural dysfunctions. Such injuries represent a serious and relatively common central nervous system condition and current treatments have limited success in the reconstruction of nerve connections in injured areas, especially where sizeable gaps are present. Biomaterial scaffolds have become an effective alternative to nerve transplantation in filling these gaps and provide the foundation for simulating the 3D structure of solid organs. However, there remain some limitations with the application of 3D bioprinting for preparation of biomaterial scaffolds. Here, the approach in constructing and testing mini‐tissue building blocks and self‐assembly, solid 3D gelatin microsphere (GM) scaffolds with multiple voids as based on the convenient preparation of gelatin microspheres by microfluidic devices is described. These 3D GM scaffolds demonstrate suitable biocompatibility, biodegradation, porosity, low preparation costs, and relative ease of production. Moreover, 3D GM scaffolds can effectively bridge injury gaps, establish nerve connections and signal transductions, mitigate inflammatory microenvironments, and reduce glial scar formation. Accordingly, these 3D GM scaffolds can serve as a novel and effective bridging method to promote nerve regeneration and reconstruction and thus recovery of nerve function after SCI.
Glasswing‐Butterfly‐Inspired Multifunctional Scleral Lens and Smartphone Raman Spectrometer for Point‐of‐Care Tear Biomarker Analysis
Authors: Narasimhan Vinayak , Siddique Radwanul Hasan , Kim Un Jeong , Lee Suyeon , Kim Hyochul , Roh YoungGeun , Wang Yibing Michelle , Choo Hyuck 
Published: December 2022

AbstractAugmenting contact lenses with sensing capabilities requires incorporating multiple functionalities within a diminutive device. Inspired by multifunctional biophotonic nanostructures of glasswing butterflies, a nanostructured scleral lens with enhanced optical, bactericidal, and sensing capabilities is reported. When used in conjunction with a smartphone‐integrated Raman spectrometer, the feasibility of point‐of‐care applications is demonstrated. The bioinspired nanostructures made on parylene films are mounted on the anterior and posterior side of a scleral lens to create a nanostructured lens. Compared to unstructured parylene, nanostructured parylene minimizes glare by 4.3‐fold at large viewing angles up to 80o. When mounted on a scleral lens, the nanostructures block 2.8‐fold more ultraviolet (UVA) light while offering 1.1‐fold improved transmission in the visible regime. Furthermore, the nanostructures exhibit potent bactericidal activity against Escherichia coli, killing 89% of tested bacteria within 4 h. The same nanostructures, when gold‐coated, are used to perform rapid label‐free multiplex detection of lysozyme and lactoferrin, the protein biomarkers of the chronic dry eye disease, in whole human tears using drop‐coating deposition Raman spectroscopy. The detection of both proteins in whole human tear samples from different subjects using the nanostructured lens produced excellent correlation with commercial enzyme‐based assays while simultaneously displaying a 1.5‐fold lower standard deviation.
Deciphering the Morphology Change and Performance Enhancement for Perovskite Solar Cells Induced by Surface Modification
Authors: Guan Nianci , Zhang Yuezhou , Chen Wei , Jiang Zhengyan , Gu Lei , Zhu Ruixue , Yadav Deependra , Li Deli , Xu Baomin , Cao Leifeng , Gao Xingyu , Chen Yonghua , Song Lin 
Published: December 2022

AbstractOrganic–inorganic perovskite solar cells (PSCs) have achieved great attention due to their expressive power conversion efficiency (PCE) up to 25.7%. To improve the photovoltaic performance of PSCs, interface engineering between the perovskite and hole transport layer (HTL) is a widely used strategy. Following this concept, benzyl trimethyl ammonium chlorides (BTACls) are used to modify the wet chemical processed perovskite film in this work. The BTACl‐induced low dimensional perovskite is found to have a bilayer structure, which efficiently decreases the trap density and improves the energy level alignment at the perovskite/HTL interface. As a result, the BTACl‐modified PSCs show an improved PCE compared to the control devices. From device modeling, the reduced charge carrier recombination and promoted charge carrier transfer at the perovskite/HTL interface are the cause of the open‐circuit (Voc) and fill factor (FF) improvement, respectively. This study gives a deep understanding for surface modification of perovskite films from a perspective of the morphology and the function of enhancing photovoltaic performance.
Runoff and drainage trade‐offs from cover crops exposed to freeze–thaw events
Authors: Muñoz‐Ventura Ariana , Christianson Reid D. , Bhattarai Rabin , Christianson Laura E. 
Published: December 2022

AbstractWinter cover crops are widely promoted for multiple ecosystem services although nutrient leaching from the plant biomass and subsequent transport of those nutrients is possible after freeze–thaw events. The objective of this study was to determine the effect of freeze–thaw conditions on both runoff and drainage or leachate water quality from two common cover crops. Rainfall simulations were performed on packed columns (20 cm diam.; 56 cm length) that included triplicate combinations of cereal rye (Secale cereale L.), forage radish (Raphanus sativus L. var. longipinnatus), and bare soil and a heavy, light, and no freezing treatment. The two cover crops reduced runoff total suspended solids concentrations and nitrate leaching compared with a bare soil control, confirming many cover cropping benefits. The heavy freezing conditions (including two nights of <–15 °C) resulted in significantly higher total phosphorus and nitrate concentrations in both runoff and leachate from the cereal rye, which had been killed, compared with unfrozen cereal rye. Some of the conditions tested in this lab‐scale study could be considered extreme (e.g., 10.1 cm h−1 rainfall × 2 h, −15.7 °C) but these results nonetheless help demonstrate the importance of effective conservation practices for both surface and subsurface flows as well as for multiple water quality parameters in the face of increasing weather variability.
Application of three methods in water‐saving wheat breeding
Authors: Li Qiang , Li Ding , Zhao Minghui , Sun Shuluan , Meng Xianghai , Qiao Wenchen 
Published: December 2022

AbstractAt present, water shortage seriously affects wheat production in many parts of the world, and to solve this problem, water‐saving wheat breeding is an important research domain. The objective of this study was to evaluate water‐saving index (WSI), yield factors, and KASP (kompetitive allele specific polymerase chain reaction) markers in water‐saving wheat breeding carried out in Hengshui region, China. The result showed as follows: (1) The new index WSI could better indicate the water‐saving performance, including the yield potential and the stability of different wheat cultivars under water limited condition (WL). (2) Referring to the degree of heat stress (D) in that year, selecting one of the three yield factors as the focus will improve the breeding efficiency of water‐saving wheat cultivars. With the increase of the D within a certain range, high water‐saving wheat cultivars showed a high grain weight (GW) under WL. Meanwhile with the decreasing of D value, high water‐saving wheat cultivars showed high spike number under WL. (3) KASP aggregation breeding will significantly improve the efficiency of water‐saving breeding. The combination with the highest effective rate of selecting water‐saving varieties carried GS5‐2334‐SNP and Dreb_SNP favorable alleles, and GW2‐6B‐1709SNP, TaMoc‐2433, and 1fehw with adverse alleles, whereas GS5‐2334‐SNP and GW2‐6B‐1709SNP that related to GW were useful markers for water‐saving breeding. These results improved our knowledge on the usage of WSI, yield factors, and KASP markers on water‐saving wheat breeding.
Cognition, function, and prevalent dementia in centenarians and near‐centenarians: An individual participant data (IPD) meta‐analysis of 18 studies
Authors: Leung Yvonne , Barzilai Nir , Batko‐Szwaczka Agnieszka , Beker Nina , Boerner Kathrin , Brayne Carol , Brodaty Henry , Cheung Karen Siu‐Lan , Corrada María M. , Crawford John D. , Galbussera Alessia A. , Gondo Yasuyuki , Holstege Henne , Hulsman Marc , Ishioka Yoshiko Lily , Jopp Daniela , Kawas Claudia H. , Kaye Jeff , Kochan Nicole A. , Lau Bobo Hi‐Po , Lipnicki Darren M. , Lo Jessica W. , Lucca Ugo , Makkar Steve R. , Marcon Gabriella , Martin Peter , Meguro Kenichi , Milman Sofiya , Poon Leonard W. , Recchia Angela , Ribeiro Oscar , Riva Emma , Rott Christoph , Sikkes Sietske AM , Skoog Ingmar , Stephan Blossom , Szewieczek Jan , Teixeira Laetitia , Tettamanti Mauro , Wilczyński Krzysztof , Sachdev Perminder 
Published: December 2022

AbstractIntroductionThere are limited data on prevalence of dementia in centenarians and near‐centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100.MethodsParticipant‐level data were obtained from 18 community‐based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta‐analysis was performed.ResultsThe mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).DiscussionAmong the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia‐free survival in C/NC remain to be understood.
Tunable Latency of Hydrosilylation Catalyst by Ligand Density on Nanoparticle Supports
Authors: Miller Susannah A. , Guironnet Damien 
Published: December 2022

AbstractFunctionalizing inorganic particles with organic ligands is a common technique for heterogenizing organometallic catalysts. We describe how coordinating molecular platinum to silica nanoparticles functionalized with a high density of norbornene ligands causes unexpected latency of the catalytic activity in hydrosilylation reactions when compared to an identical reaction in which the norbornene is not tethered (2 % vs 97 % conversion in 1 h). Performing the hydrosilylation at elevated temperature (70 °C) suppresses this activity delay, suggesting the usefulness of this technique towards temperature‐triggered catalysis. We demonstrate that this latency is related to ligand density on the particle surface, chemical structure of the norbornene, and silica nanoparticle topology. We also establish the benefit of this latency for triggered curing of silicone elastomers. Overall, our work establishes the non‐innocent role of inorganic supports when functionalized with organometallic complexes.
Efficient selective methylene blue adsorption by polyurethane/montmorillonite‐based antifouling electrospun composite membranes
Authors: Kandiyil Juraij , Vasudevan Suni , Athiyanathil Sujith 
Published: December 2022

AbstractA robust antifouling membrane with pollutant‐removing capacity is in high demand for industrial wastewater treatment. Here, we report a new multifunctional polyurethane/montmorillonite‐oxidized multi‐walled carbon nanotube (PU/MMT) nanofibrous composite membrane, beneficial for both water filtration and selective methylene blue adsorption. It was observed that oxidized multi‐walled carbon nanotube (o‐MWCNT) imparted high flexibility with a high percentage elongation (318%–405%) to the composites, whereas montmorillonite (Mt) improved the hydrophilicity, antifouling property, and dye adsorption capacity of the fibrous PU membrane. The sample with 20 wt% Mt (PU/20‐MMT) showed a minimum water contact angle of 57°. It showed a high water flux, oil rejection, and flux recovery ratio compared to the pristine electrospun PU membrane. The Hermia fouling mechanism suggested that electrospun PU obeyed an intermediate blocking model, whereas PU/20‐MMT was best fitted with a cake formation model. During adsorption, the cationic dye methylene blue (MB) was selectively adsorbed on the sample from a methyl orange/methylene blue (MO/MB) mixture. It showed a maximum adsorption capacity (qm) of 112.35 mg/g. The anionic dye methyl orange, on the other hand, remained unadsorbed. The adsorption kinetics and the adsorption isotherm were pseudo‐second‐order kinetics and the Langmuir adsorption isotherm, respectively. The developed, robust electrospun composite membrane opens a new avenue for the selective adsorption of MB from dye mixtures and contaminated water.
Self‐healing and reprocess of crosslinked polyurethane based on dynamic oxime‐carbamate bond
Authors: Zhang Aiqin , Long Jian , Jia Liang , Gao Qiang , Fan Haojun , Xiang Jun 
Published: December 2022

AbstractPolymer materials containing oxime‐carbamate bonds show superior self‐healing ability under certain conditions. In this study, a series of dynamic oxime‐carbamate based PU‐D‐x (Polyurethane‐Dimethylglyoxime‐x) with different crosslinking degrees (x indicates the content of crosslinker based on the weight of solid content) were prepared, and the self‐healing together with the reprocessing characteristic was investigated. In situ variable temperature FTIR spectroscopy shows that the dissociation of oxime‐carbamate bonds occurred at 80°C and can be accelerated by the increasing temperature. With relatively lower cross‐linking degrees, these types of PU can be healed at low temperature and in a short time, for example, PU‐D‐0.3 can be completely healed at 80°C in 6 h, and PU‐D‐0.45 can be almost completely healed at 80°C in 9 h. With the increase of cross‐linking degree, the self‐repair of this kind of PU needs to be carried out at higher temperature and needs an extension of time. However, when the temperature increased to 100°C, the self‐healing time is greatly reduced to 3–5 h. Most interestingly, these types of crosslinked PUs showed expected reusing and reprocessing characteristics, even the PU‐D‐1.2 sample with the highest crosslinking degree can be completely reshaped and reprocessed under 120°C and 10 MPa pressure.
A method for the treatment of black tea waste: Converting it into liquid mulching film and solid mulching film
Authors: Sun Wei , Liu Xin , Li Xiang , Wang Shujie , Li Qing , Sun Zhonghua 
Published: December 2022

AbstractThis work was aim to prepare biodegradable mulching film from biomass materials to reduce the environmental pollution caused by plastics. Black tea waste was divided into two parts and combined with degradable materials such as polyvinyl alcohol and cellulose to prepare two degradable mulching films: liquid mulching film (LMF) and solid mulching film (SMF). The optimum formula was developed after studying the effects of various components of degradable mulching film on mechanical properties in both dry and wet circumstances. The properties of LMF and SMF were characterized and tested by scanning electron microscope (SEM), Fourier transform infrared spectrometer (FTIR), light transmittance test, contact angle test, water resistance test, artificial accelerated aging test, and degradation performance test. The results demonstrated that LMF and SMF had good mechanical properties, resistance to ultraviolet light, water resistance, aging resistance, and biodegradation. Using tea waste to prepare mulching film material has the advantages of no pollution, easy biodegradation, and good biocompatibility.
The effect of alcoholic solutions on the thermomechanical properties of immersed poly(lactic acid) films
Authors: Xu Dian , Auras Rafael A. , Sonchaeng Uruchaya , Rubino Maria , Lim Loong‐Tak 
Published: December 2022

AbstractThe effects of aqueous and deuterium oxide (D2O) solutions of alcohols (methanol, ethanol, 1‐propanol, 2‐propanol, and 1‐butanol) on the thermomechanical properties of poly(lactic acid)—PLA—films were assessed by dynamic mechanical analysis. The glass transition temperature (Tg) of PLA films immersed in 25%, 50%, 75%, and 100% (v/v) alcoholic solutions were compared with the Tg of films immersed in 100% water and D2O. The Tg of PLA films immersed in methanol and ethanol aqueous solutions decreased as the concentration of the alcohol solutions increased. For methanol and ethanol, the Tg decreased by 8.6 and 7.6°C per 25% (v/v) increase in alcohol, respectively. When the PLA films were immersed in propanol aqueous solutions and butanol, the Tg reached the lowest value at 75% (v/v) and 100% (v/v), respectively. Tg of PLA films immersed in 1‐propanol and 2‐propanol decreased by 8.6 and 8.9°C for every 25% increase in propanol before reaching the minimum value, respectively. Aqueous and D2O solutions had similar effects on Tg. Selective studies of crystallinity evolution, ethanol sorption, degree of swelling, and Hansen solubility parameters of PLA were conducted. This work assists in developing PLA films intended for contact with aqueous‐alcoholic solutions.