bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute kidney injury in 18 cats after subcutaneous meloxicam and an update on non‐steroidal anti‐inflammatory drug usage in feline patients in Australia
Authors: Wun MK , Leister E , King T , Korman R , Malik R 
Published: December 2022

ObjectivesAcute kidney injury (AKI) is a well‐known but poorly documented adverse effect of non‐steroidal anti‐inflammatory drugs (NSAIDs) in cats. We aimed to describe instances of NSAID‐associated AKI in cats and survey Australian veterinarians on NSAID use in acute settings.MethodsMedical records of cats that developed an AKI subsequent to the administration of meloxicam were obtained by searching the databases of seven practices in Queensland, as well as by contemporaneously contacting select veterinary colleagues of the authors in both general and specialist small animal practice. An online questionnaire was created for the survey, and the URL distributed to Australian practitioners.ResultsA total of 18 cases were retrieved, all of which received injectable meloxicam. The indication(s) for its use and the dosage prescribed were within the manufacturer's recommendations for Australian veterinarians. The majority of cases (13/18 cats) received the label dose of 0.3 mg/kg subcutaneously (SC) on the day of the procedure. In 12/18 cats, the injection was given in association with general anaesthesia or sedation. Fourteen cats survived to hospital discharge. Of 187 survey respondees, 89% routinely administered NSAIDs for surgery‐related analgesia, with 98% prescribing meloxicam and 84% of these giving it SC. Ninety percent of respondees routinely administered NSAIDs for non‐surgical‐related analgesia, with 99% prescribing meloxicam and 35% of those giving it SC.Conclusions and RelevanceWe strongly recommend that practitioners avoid prescribing meloxicam SC in cats. This recommendation is emphatic in situations where concurrent dehydration and/or hypotension are possible.
Relating transcription, executive functions and text quality in Grades 2–3: A cross‐lagged panel analysis
Authors: Vieira Ana Isabel , Magalhães Sofia , Limpo Teresa 
Published: December 2022

AbstractBackgroundIt has been suggested that children's writing is dependent on transcription and executive functions. However, there is a need for more research examining the relationships among those variables in primary school children, given that most existing studies are cross‐sectional and assess transcription and executive functions separately, and there are scarce and mixed longitudinal findings.AimsThis study used a cross‐lagged panel model to explore the relationships among transcription skills, executive functions and text quality from Grade 2 to Grade 3.SampleThe sample included 353 Portuguese children (195 boys, 155 girls) in Grade 2, who were reassessed in Grade 3.MethodsChildren were assessed on transcription, executive functions and writing tasks at two time points.ResultsTranscription skills and executive functions in Grade 2 positively predicted the same variables in Grade 3. At Grade 2, transcription skills were associated with executive functions and text quality. At Grade 3, we only found an association between executive functions and text quality. Finally, text quality in Grade 2 predicted transcription skills in Grade 3, but both transcription and executive functions in Grade 2 did not predict text quality in Grade 3.ConclusionsTranscription skills and executive functions seem to be stable over time, but previous performance on these skills does not seem to predict later text quality. Overall, these findings do put into question the direction of the typically assumed relationships, especially between transcription and text quality. Findings also provide information that can guide the development of instructional programmes in primary school.
Orthogonal threading‐through‐β‐sheet design of lung cancer EGFR extracellular domain‐derived peptidic mimotopes binding to anti‐EGFR antibody
Authors: Zhang Xian‐Chao , Chang Na , Zhang Xian‐Qi 
Published: December 2022

AbstractHuman epidermal growth factor receptor (EGFR) has been established as a therapeutic target of lung cancer and other diverse tumors. The antibody drug Cetuximab has been developed to target the third subdomain III (TSDIII) of EGFR extracellular domain (ECD) by competitively inhibiting epidermal growth factor binding. In this study, we performed systematic investigation on the crystal complex structure of EGFR ECD domain with Cetuximab to create a residue importance profile for the TSDIII subdomain, based on which a number of U‐shaped, double‐stranded linear peptides were derived and cyclized to orthogonally thread through most hotspot residues and many responsible residues within the TSDIII β‐sheet plane; they represent mimotopes of the key antibody‐recognition site of TSDIII subdomain. Computational analyses revealed that these linear peptides cannot spontaneously fold to the desired conformation in free state due to their intrinsic flexibility. Cell‐free assays confirmed that the stapling can considerably improve the binding affinity of linear peptides to Cetuximab by up to 18‐fold. The cOrt1 [3–18] cyclic peptide was measured to have the highest affinity in all designed linear and cyclic peptides.
The effect of the endoscopic device Endocuff™/Endocuff vision™ on quality standards in colonoscopy: A systematic review and meta‐analysis of randomized trials
Authors: Walls Martin , Houwen Britt B. S. L. , Rice Stephen , Seager Alexander , Dekker Evelien , Sharp Linda , Rees Colin J. 
Published: December 2022

AbstractAimThe adenoma detection rate (ADR) is an important quality measure, with a high ADR reflecting high‐quality colonoscopy. This systematic review and meta‐analysis aimed to assess the effects of Endocuff™/Endocuff Vision™‐assisted colonoscopy (EAC) versus standard colonoscopy (SC) on ADR and other clinical, patient and resource‐use outcomes.MethodMEDLINE, EMBASE, Web of Science, Scopus and the Cochrane Central Register of Controlled Trials were searched for full papers reporting randomized studies comparing EAC with SC. The primary outcome was ADR. Secondary outcomes comprised key polyp/adenoma detection, procedure‐related, patient‐related and health economic measures. Random effects meta‐analyses provided pooled estimates of outcomes [risk ratio (RR) or mean difference (MD), with 95% confidence intervals (CI)].ResultsTwelve parallel‐group randomized controlled trials (RCTs) and three crossover RCTs with data on 9140 patients were included. EAC significantly increased the ADR (RR 1.18, 95% CI 1.09–1.29), mean adenomas per procedure (MAP) (MD 0.19, 95% CI 0.06–0.33), polyp detection rate (PDR) (RR 1.20, 95% CI 1.10–1.30) and mean polyps per procedure (MPP) (MD 0.39, 95% CI 0.14–0.63) versus SC. EAC significantly increased segmental PDR versus SC in the sigmoid (RR 2.02, 95% CI 1.64–2.49), transverse (RR 1.63, 95% CI 1.09–2.42), ascending (RR 1.74, 95% CI 1.26–2.41) and caecal segments (RR 1.91, 95% CI 1.29–2.82). Procedure‐related variables did not differ between arms. There were insufficient data for meta‐analysis of health economic or patient‐centred outcomes.ConclusionsEAC increased ADR, MAP, PDR and MPP versus SC without detrimental effects on procedure measures. Cost‐effectiveness and patient experience data are lacking and would be valuable to inform practice recommendations.
Some novel operational laws and spherical fuzzy Choquet‐Frank operators and their application to MCDM
Authors: Punetha Tanuja , Komal  
Published: December 2022

AbstractSome decision‐making problems are required to be analysed using insufficient and vague information under an extended space of fuzziness, considering flexibility in the decision‐making process and the interdependency and interaction between the criteria. To tackle these challenges, a spherical fuzzy set (SFS), which is an extension of the ordinary picture fuzzy set (PFS), can be used to fulfil the requirement of an extended space of fuzziness by quantifying uncertainty. Similarly, the Frank operations can provide flexibility to the decision‐making process due to the involvement of a parameter, whereas the Choquet integral considers all possible interactive characteristics between different criteria. Therefore, this paper integrates these three important concepts to make more sound and realistic decisions by extending the existing arithmetic operation for spherical fuzzy numbers (SFNs) using Frank t‐norm and t‐conorm. In addition, the paper introduces some novel Choquet‐Frank aggregation operators, such as spherical fuzzy Choquet‐Frank averaging (SFCFA) and spherical fuzzy Choquet‐Frank geometric (SFCFG). To demonstrate the effectiveness of the proposed operators, a multi‐criteria decision making (MCDM) problem related to the selection of an enterprise resource planning (ERP) system is analysed for the available five options , and . Sensitivity analysis is performed to investigate the impact of taking variation in parameter values () on aggregated values. Results confirmed that the best alternatives for SFCFA and SFCFG operators are and , respectively, while is the worst alternative for both these operators. To show the effectiveness of the proposed operators, a comparative analysis has been performed to compare the results obtained from other existing aggregation operators. Results concluded that the findings resemble most of the existing operators which confirms the feasibility of the proposed operators.
Longer duration of seasonal stratification contributes to widespread increases in lake hypoxia and anoxia
Authors: Jane Stephen F. , Mincer Joshua L. , Lau Maximilian P. , Lewis Abigail S. L. , Stetler Jonathan T. , Rose Kevin C. 
Published: December 2022

AbstractThe concentration of dissolved oxygen (DO) is an important attribute of aquatic ecosystems, influencing habitat, drinking water quality, biodiversity, nutrient biogeochemistry, and greenhouse gas emissions. While average summer DO concentrations are declining in lakes across the temperate zone, much remains unknown about seasonal factors contributing to deepwater DO losses. It is unclear whether declines are related to increasing rates of seasonal DO depletion or changes in seasonal stratification that limit re‐oxygenation of deep waters. Furthermore, despite the presence of important biological and ecological DO thresholds, there has been no large‐scale assessment of changes in the amount of habitat crossing these thresholds, limiting the ability to understand the consequences of observed DO losses. We used a dataset from >400 widely distributed lakes to identify the drivers of DO losses and quantify the frequency and volume of lake water crossing biologically and ecologically important threshold concentrations ranging from 5 to 0.5 mg/L. Our results show that while there were no consistent changes over time in seasonal DO depletion rates, over three‐quarters of lakes exhibited an increase in the duration of stratification, providing more time for seasonal deepwater DO depletion to occur. As a result, most lakes have experienced summertime increases in the amount of water below all examined thresholds in deepwater DO concentration, with increases in the proportion of the water column below thresholds ranging between 0.9% and 1.7% per decade. In the 30‐day period preceding the end of stratification, increases were greater at >2.2% per decade and >70% of analyzed lakes experienced increases in the amount of oxygen‐depleted water. These results indicate ongoing climate‐induced increases in the duration of stratification have already contributed to reduction of habitat for many species, likely increased internal nutrient loading, and otherwise altered lake chemistry. Future warming is likely to exacerbate these trends.
Use of fermented sprouted mung bean (Vigna radiata) containing protective starter culture LAB to produce clean‐label fortified wheat bread
Authors: Aryashad Mohammad , Sadeghi Alireza , Nouri Mehrnaz , Ebrahimi Maryam , Kashaninejad Mahdi , Aalami Mehran 
Published: December 2022

SummaryPredominant antifungal lactic acid bacteria (LAB) isolated from fermented sprouted mung bean (FSM) was used as protective starter culture in controlled FSM to produce a clean‐label fortified wheat bread. Sequencing results of the PCR products led to the identification of Pediococcus pentosaceus as the selected LAB isolate. The rate of surface growth of Aspergillus niger on FSM‐added bread was significantly (P < 0.05) lower than the wheat bread containing mung bean, fermented mung bean and sprouted mung bean alone. The quantity of almost all of the amino acids (aspartic acid, histidine, serine, arginine, threonine, tyrosine, valine, phenylalanine and tryptophane) in the FSM‐added wheat bread was also higher than the control, according to the HPLC analysis. Furthermore, bread containing FSM had the highest mould‐free shelf‐life (4 days) and porosity (21.61%). Meanwhile, there was no significant (P > 0.05) difference in terms of crumb hardness, specific volume and overall acceptability among the produced samples.
Synergistic effect of gum arabic and xanthan gum on improving rheological properties of low‐fat mayonnaise with egg white protein microparticle as a fat mimetic
Authors: Shi Yefan , Li Junhua , Gu Luping , Su Yujie , Chen Wangying , Zhang Ming , Chang Cuihua , Yang Yanjun 
Published: December 2022

SummaryOverconsumption of fat‐rich foods has led to a significant increase in the incidence of chronic diseases in humans. With the increased pursuit of a healthy lifestyle, low‐fat products are gradually developing. In this study, egg white protein microparticle (EWPM) was used as a fat mimetic in low‐fat mayonnaise, as well as xanthan gum (XG) and gum arabic (GA) were used as texture and rheology modifiers. The results showed that XG and GA had a synergistic effect on modifying viscosity and recovery of EWPM‐structured low‐fat mayonnaise. The addition of XG could effectively increase the viscosity of low‐fat system, due to the electrostatic binding with EWPM and the intermolecular entanglement. The incorporation of XG with GA could effectively intervene intermolecular interactions to improve recovery, verified by the decreased particle size and weakened electrostatic binding. The results would provide practical guidance for the development of high‐protein and low‐fat nutritious mayonnaise.
Physico‐chemical, sensory, antioxidant and electromyographic analyses of functional liquid diets (IDDSI levels 0–2) formulated for dysphagia patients
Authors: Sodhi Navdeep Singh , Dhillon Bhavnita , Kaur Ramneet , Goria Gurleen , Sharma Shivangi , Jaiswal Sunanda 
Published: December 2022

SummaryDysphagia is a symptom that refers to difficulty during the progression of the alimentary bolus from the mouth to the stomach. This may lead to malnutrition and negative effects on quality of life. Doctors and dieticians around the globe are looking for nutritious texture‐modified diets which are easier to chew and swallow thus could reduce the risks associated with choking in dysphagia patients. In this study, different functional liquid diets were formulated under International Dysphagia Diet Standardization Initiative (IDDSI) levels 0–2. The diets were made with incorporation of various fruits and vegetables to enhance their nutritional profile. The formulated liquid diets were analysed for their proximate composition, colour, antioxidant and sensory properties. The formulated liquid diets were high in nutrients and antioxidants. Also, all the formulated products were highly acceptable based on various sensory attributes indicating their potential to be incorporated in the diet plan of dysphagia patients. Electromyography (EMG) study was conducted to acquire myoelectrical activities of both masseter and suprahyoid muscles during oral processing of liquid diets by human subjects. The acquired EMG oral processing parameters significantly (P < 0.05) correlated with ease of swallowing and IDDSI levels. Hence, EMG technique provides in vivo texture evaluation and real‐time swallowing patterns and thus can be an effective approach for the formulation of texture‐modified diets for dysphagia patients.
Decision and foreknowledge
Authors: Gallow J. Dmitri 
Published: December 2022

AbstractMy topic is how to make decisions when you possess foreknowledge of the consequences of your choice. Many have thought that these kinds of decisions pose a distinctive and novel problem for causal decision theory (CDT). My thesis is that foreknowledge poses no new problems for CDT. Some of the purported problems are not problems. Others are problems, but they are not problems for CDT. Rather, they are problems for our theories of subjunctive supposition. Others are problems, but they are not new problems. They are old problems transposed into a new key. Nonetheless, decisions made with foreknowledge illustrate important lessons about the instrumental value of our choices. Once we've appreciated these lessons, we are left with a version of CDT which faces no novel threats from foreknowledge.
Impacts of micronutrient intervention programs on effective coverage and lives saved: Modeled evidence from Cameroon
Authors: Vosti Stephen A. , Adams Katherine P. , Michuda Aleksandr , Ortiz‐Becerra Karen , Luo Hanqi , Haile Demewoz , Chou Victoria B. , Clermont Adrienne , Teta Ismael , Ndjebayi Alex , Kagin Justin , Guintang Jules , Engle‐Stone Reina 
Published: December 2022

AbstractPolicymakers are committed to improving nutritional status and to saving lives. Some micronutrient intervention programs (MIPs) can do both, but not to the same degrees. We apply the Micronutrient Intervention Modeling tool to compare sets of MIPs for (1) achieving dietary adequacy separately for zinc, vitamin A (VA), and folate for children and women of reproductive age (WRA), and (2) saving children's lives via combinations of MIPs. We used 24‐h dietary recall data from Cameroon to estimate usual intake distributions of zinc and VA for children 6–59 months and of folate for WRA. We simulated the effects on dietary inadequacy and lives saved of four fortified foods and two VA supplementation (VAS) platforms. We estimated program costs over 10 years. To promote micronutrient‐specific dietary adequacy, the economic optimization model (EOM) selected zinc‐ and folic acid–fortified wheat flour, VA‐fortified edible oils, and bouillon cubes, and VAS via Child Health Days in the North macroregion. A different set of cost‐effective MIPs emerged for reducing child mortality, shifting away from VA and toward more zinc for children and more folic acid for WRA. The EOM identified more efficient sets of MIPs than the business‐as‐usual MIPs, especially among programs aiming to save lives.
Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28‐week clinical and biomarker results from the BioDay registry
Authors: Kamphuis Esmé , Boesjes Celeste M. , Loman Laura , Bakker Daphne S. , Poelhekken Mila , Zuithoff Nicolaas P. A. , Kamsteeg Marijke , Romeijn Geertruida L. E. , van Wijk Femke , de Bruin‐Weller Marjolein S. , de Graaf Marlies , Schuttelaar Marie L. A. 
Published: December 2022

AbstractBackgroundDupilumab has proven to be an effective and safe treatment for atopic dermatitis (AD) in pediatric patients in clinical trials. However, few daily practice studies are available. The aim of this study is to evaluate the effect of 28 weeks dupilumab treatment on effectiveness, safety, and serum biomarkers in pediatric patients with moderate‐to‐severe AD in daily practice.MethodsPatients visited the outpatient clinic at baseline, 4, 16, and 28 weeks of treatment. Disease severity was assessed by the Eczema Area and Severity Index (EASI), Investigator Global Assessment (IGA), Numeric Rating Scale (NRS)‐pruritus and ‐pain, and the Patient‐Oriented Eczema Measure (POEM). Side effects were evaluated. Nineteen severity‐associated serum biomarkers were measured. Predicted‐EASI (p‐EASI) was calculated.ResultsSixty‐one patients were included. Respectively 75.4%, 49.2%, and 24.6% reached EASI‐50, EASI‐75, and EASI‐90 and 36.1% achieved an IGA‐score (almost) clear. Improvement of ≥4 points on POEM, NRS‐pruritus, and NRS‐pain was reached by 84.7%, 45.3%, and 77.4%, respectively. Most reported side effects were conjunctivitis (n = 10) and headache (n = 4). Biomarkers TARC, PARC, periostin, sIL‐2Ra, and eotaxin‐3 significantly decreased during treatment. The p‐EASI showed a significant correlation with disease severity.ConclusionDupilumab treatment significantly improved disease severity and disease‐associated symptoms and decreased severity‐associated serum biomarkers in pediatric AD patients in daily practice.
Allergenic risk assessment of cowpea and its cross‐reactivity with pea and peanut
Authors: Chentouh Mouhamed Mounir , Codreanu‐Morel Françoise , Boutebba Aissa , Kler Stephanie , Revets Dominique , Kuehn Annette , Ollert Markus , Hilger Christiane 
Published: December 2022

AbstractBackgroundNovel protein sources can represent a risk for allergic consumers. The aim of this study was to evaluate the allergenicity of cowpea (Vigna unguiculata), an increasingly consumed legume and potential new industrial food ingredient which may put legume‐allergic patients at risk.MethodsChildren with allergy to legumes associated to peanut (LP group: n = 13) or without peanut allergy (L group: n = 14) were recruited and sensitization to several legumes including cowpea was assessed by prick tests and detection of specific IgE (sIgE). Cowpea protein extract was analyzed by SDS‐PAGE and immunoblotting, IgE‐reactive spots were subjected to mass spectrometry. IgE‐cross‐reactivity between cowpea, pea, and peanut was determined using ELISA inhibition assays. Basophil activation tests were performed to evaluate sensitivity and reactivity of patient basophils toward legumes.ResultsPrick tests and sIgE levels to cowpea were positive in 8/14 and 4/13 patients of the L group and in 9/13 and 10/13 patients of the LP group, respectively. Four major IgE‐binding proteins were identified as vicilins and seed albumin. Cowpea extract and its vicilin fraction strongly inhibited IgE‐binding to pea and peanut extract. Peanut, lentil, and pea were the strongest activators of basophils, followed by cowpea, soybean, mung bean, and lupin.ConclusionA majority of patients with legume allergy were sensitized to cowpea proteins. Four novel allergens were identified in cowpea, among which storage proteins were playing an important role in IgE‐cross‐reactivity, exposing legume‐allergic patients to the risk of clinical cross‐reactivity to cowpea and thus adding cowpea to the group of nonpriority legumes that are not subjected to allergen labeling such as chickpea, pea, and lentil.
Design Criteria for Jet-Propelled Helicopter Rotors
Authors: Denney C. D. 
Published: December 2022

Abstract
Considerable developmental work is progressing on various types of jet rotor systems for helicopters. Among these are the ramjet system, and the pressure system, which are described in some detail in the paper. Application of the gas turbine for driving the compressor used in the pressure system is considered briefly, as well as use of the turbojet engine. A comparison of performance of the two principal jet-rotor systems under consideration with conventional helicopter-rotor drive is given, which indicates advantages for short-haul application over the conventional drive.
Test Results of High-Performance Heat-Exchanger Surfaces Used in Aircraft Intercoolers and Their Significance for Gas-Turbine Regenerator Design
Authors: London A. L. , Ferguson C. K. 
Published: December 2022

Abstract
This paper presents basic heat-transfer and flow-friction design data for a plate louvered-fin type of extended surface which may be of use in the gas-turbine-plant regenerator application. Different surfaces are compared on the basis of a heat-transfer coefficient versus friction-horse-power plot, and some of the heat-transfer and flow-friction aspects of regenerator design are discussed.