bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Attitude, and Psychological Impacts of COVID-19 in Saudi Arabia
Authors: Alanazi Naif , Bahjri Khaled 
Published: February 2022

BackgroundThe world has been facing an unprecedented pandemic of COVID-19 with over 336 million people infected and millions of deaths. This required an enormous communication effort response from governments, international, and individuals to keep the public informed about the outbreak. When a pandemic affects communities, individuals' knowledge and attitude are important factors to contain the outbreak. Thus, the purpose of this study is to measure individuals' knowledge and attitude toward COVID-19 and ascertain whether a need exists for mental health services for those who were affected by the pandemic.MethodsA cross-sectional design was used to measure the knowledge, attitude, and psychological impacts about the COVID-19 pandemic among the Saudi population. Research participants were recruited using a snowball sampling technique through the social media platform WhatsApp. A total of 482 eligible individuals participated from various locations in Saudi Arabia represented almost all Saudi regions. The questionnaire consisted of seven questions evaluating knowledge, seven gauging attitudes, and 16 questions assessing anxiety and perceived need for mental healthcare services.ResultsA modest level of knowledge (59%) was found among the Saudi population sampled about the COVID-19 pandemic, and satisfactory knowledge (&gt;80%) about its preventive measures. Anxiety and stress existed among the participants (79% obsessed with COVID-19), with an 88% approval rate for obtaining mental health services for individuals highly affected by the pandemic.ConclusionThere is a need to increase awareness and provide continuous updates regarding the pandemic situation. Promoting access to mental health services is critical, as well as finding creative and suitable strategies to deliver mental health services to those who need them.
Involving Animal Models in Uterine Transplantation
Authors: Favre-Inhofer Angeline , Carbonnel Marie , Domert Johanna , Cornet Nathalie , Chastant Sylvie , Coscas Raphaël , Vialard François , Gelin Valérie , Galio Laurent , Richard Christophe , Trabelsi Héla , Sandra Olivier , de Ziegler Dominique , Chavatte-Palmer Pascale , Ayoubi Jean-Marc 
Published: February 2022

BackgroundAbsolute uterine factor infertility affects 0. 2% women of childbearing age around the world. Uterine transplantation (UTx) is a promising solution for many of them since the first birth from UTx was described by the Swedish team in 2014. The success of Utx in humans has become possible after a systematic and meticulous approach involving years of research on animal models. To date, more than 80 UTx procedures have been performed worldwide and 30 children were born.Material and MethodThis review summarizes the research preparation conducted in animals before beginning UTx in humans. It focuses on the advantages and limits of each animal model, their place in surgical training, and current contribution in research to improve UTx successes in humans. The different steps in the process of UTx have been analyzed, such as imaging, surgery, ischemia-reperfusion effects, rejection markers, immunosuppressive treatment, and pregnancy.ConclusionAnimal models have played an essential role in the implementation of UTx, which is a highly complex procedure. While respecting the 3R requirements (replacement, refinement, and reduction), the surgical training using large animal models, such as notably ewes remain irreplaceable for teams wishing to initiate a UTx program. Furthermore, animal models are still mandatory in current research to improve the success rates of UTx in humans as well as to reduce the morbidity associated with this experimental infertility treatment.
Mitigating SARS-CoV-2 Transmission in Hospitals: A Systematic Literature Review
Authors: Ng Chester Yan Hao , Lim Nicole-Ann , Bao Lena X. Y. , Quek Amy M. L. , Seet Raymond C. S. 
Published: February 2022

Objectives: Hospital outbreaks of SARS-CoV-2 infection are dreaded but preventable catastrophes. We review the literature to examine the pattern of SARS-CoV-2 transmission in hospitals and identify potential vulnerabilities to mitigate the risk of infection.Methods: Three electronic databases (PubMed, Embase and Scopus) were searched from inception to July 27, 2021 for publications reporting SARS-CoV-2 outbreaks in hospital. Relevant articles and grey literature reports were hand-searched.Results: Twenty-seven articles that described 35 SARS-CoV-2 outbreaks were included. Despite epidemiological investigations, the primary case could not be identified in 37% of outbreaks. Healthcare workers accounted for 40% of primary cases (doctors 17%, followed by ancillary staff 11%). Mortality among infected patients was approximately 15%. By contrast, none of the infected HCWs died. Several concerning patterns were identified, including infections involving ancillary staff and healthcare worker infections from the community and household contacts.Conclusion: Continuous efforts to train-retrain and enforce correct personal protective equipment use and regular routine screening tests (especially among ancillary staff) are necessary to stem future hospital outbreaks of SARS-CoV-2.
Mismatches between Morphology and DNA in Italian Partridges May Not Be Explained Only by Recent Artificial Release of Farm-Reared Birds
Authors: Fontaneto Diego , Viola Paolo , Pizzirani Claudia , Chiesa Stefania , Rossetti Alessandro , Amici Andrea , Lucentini Livia 
Published: February 2022

Translocations and releases of farm-reared birds are considered among the major drivers of genetic pollution with consequent loss of genetic diversity in wild populations. In this study, we aimed to assess the extent of hybridization and introgression in the Italian partridges as a consequence of translocation. We surveyed two mitochondrial markers and one nuclear marker of Alectoris and Perdix from collections (museums and private collections), extant wild populations and farms. Consistent with previous studies, we found haplotypes of allochthonous species within the same genus, likely due to introductions for hunting activities. In addition, we found hybrids between Perdix and Alectoris species with genetic markers from both genera in single individuals. Such introgression was bidirectional and in both mitochondrial and nuclear markers. Counterintuitively, most of the hybrid samples came from collections before the 1950s, when large-scale translocations started, from wild populations where Grey Partridge (Perdix perdix) and Rock Partridge (Alectoris graeca) overlap in their distribution, whereas only one hybrid occurred among the farmed birds. Our results suggest that Perdix and Alectoris species can hybridize in nature and that artificial translocations and releases of farm-reared birds for restocking or reintroduction purposes may be only partially responsible for the genomic mismatches of Italian partridges.
Update on Stachybotrys chartarum—Black Mold Perceived as Toxigenic and Potentially Pathogenic to Humans
Authors: Dyląg Mariusz , Spychała Klaudyna , Zielinski Jessica , Łagowski Dominik , Gnat Sebastian 
Published: February 2022

In nature, there are many species of fungi known to produce various mycotoxins, allergens and volatile organic compounds (VOCs), as well as the commonly known etiological agents of various types of mycoses. So far, none of them have provoked so much emotion among homeowners, builders, conservators, mycologists and clinicians as Stachybotrys chartarum. This species compared to fungi of the genera Fusarium and Aspergillus is not as frequently described to be a micromycete that is toxigenic and hazardous to human and animal health, but interest in it has been growing consistently for three decades. Depending on the authors of any given review article, attention is focused either on the clinical aspects alongside the role of this fungus in deterioration of biomaterials, or aspects related to its biology, ecology and taxonomic position. On the one hand, it is well established that inhalation of conidia, containing the highest concentrations of toxic metabolites, may cause serious damage to the mammalian lung, particularly with repeated exposure. On the other hand, we can find articles in which authors demonstrate that S. chartarum conidia can germinate and form hyphae in lungs but are not able to establish an effective infection. Finally, we can find case reports that suggest that S. chartarum infection is linked with acute pulmonary hemorrhage, based on fungal structures recovered from patient lung tissue. New scientific reports have verified the current state of knowledge and note that clinical significance of this fungus is exceedingly controversial. For these reasons, understanding S. chartarum requires reviewing the well-known toxigenic features and harmful factors associated with this fungus, by gathering the newest ones into a coherent whole. The research problem related to this fungus seems to be not overly publicized, and there is still a demand to truthfully define the real threats of S. chartarum and phylogenetically related species. The most important problem, which should be fully elucidated as soon as possible, remains the clarification of the pathogenicity of S. chartarum and related species. Maybe it is urgent time to ask a critical question, namely what exactly do we know 28 years after the outbreak of pulmonary hemorrhage in infants in Cleveland, Ohio, USA most likely caused by S. chartarum?
Pengaruh Moril Kerja dan Kesediaan Menghadapi Perubahan Terhadap Keterlibatan Kerja Personil Satlantas Di Kepolisian Resort Kota Besar Medan
Authors: Dalimunte Abdul Hamid , Lubis Saiful Ahyar , Lubis M. Rajab 
Published: February 2022

The purpose of this study is to see: the influence of work moril and willingness readiness of changes to the work involvement of satlantas personnel in the Police Resort Kota Besar Medan. The hypothesis proposed is there is a moral influence of work and willingness readiness of changes to work engagement. The research was conducted on 70 Satlantas personnel with sampling techniques is purposive sampling. Data retrieval by scale method is the scale of work engagement, the moral scale of work and the scale of willingness to readiness change. The results showed; 1). There is a significant influence between the morale of work and willingness readiness of changes to work engagement. Coefficient Freg = 110.037; p = 0.000 where p < 0.050. Thus the hypothesis presented in this study is accepted, 2). There was a very significant influence between work morale on work engagement, with a correlation coefficient of 0.716 and an effective contribution of 51.2%. 3). There was a very significant influence between willingness readiness of change and work engagement, with a correlation coefficient of 0.818 and an effective contribution of 66.9%. The moral influence of work and willingness readiness of changes to work engagement is as large. 76,7%. thus there were still 23.3% influenced by other factors not studied in this study.
Dysbacteriosis as an Aspect of the Pathogenesis of Periodontal Disease
Authors: Бобкова И.Л. , Зиновенко О.Г. 
Published: February 2022

Микрофлора полости рта представляет собой высокочувствительную индикаторную систему, реагирующую качественными и количественными сдвигами на изменения состояния различных органов и систем человеческого организма в целом. Постоянство микробного состава ротовой полости поддерживается благодаря свойству нормальной микрофлоры противостоять патогенным и условно-патогенным микроорганизмам. При генерализованном пародонтите в содержимом пародонтальных карманов отмечается резкое снижение количества лактобактерий. Возникает дисбактериоз, выраженность которого соответствует степени тяжести поражения пародонта. В связи с этим перспективным направлением в разработке новых методов комплексного лечения пародонтита является использование бактерийных препаратов, действующим началом которых являются штаммы представителей нормальной микрофлоры.Цель. Изучение влияния метода лечения хронического пародонтита, включающего использование отечественного пробиотика и низкоинтенсивного лазерного излучения, на содержание лактобактерий в содержимом пародонтальных карманов.Материалы и методы. Объектом исследования явились 100 пациентов с диагнозом «хронический генерализованный периодонтит» средней и среднетяжелой степени тяжести.Результаты. Включение в состав комплексного лечения пациентов с хроническим пародонтитом на фоне соматической патологии местного применения отечественного пробиотика в сочетании с низкоинтенсивным лазерным излучением способствует нормализации микроэкологии пародонтальных карманов.
The microflora of the oral cavity is a highly sensitive indicator system that reacts with qualitative and quantitative shifts to changes in the state of various organs and systems of the human body as a whole. The constancy of the microbial composition of the oral cavity is maintained due to the property of normal microflora to resist pathogenic and opportunistic microorganisms. With generalized periodontitis, a sharp decrease in the number of lactobacilli is noted in the contents of periodontal pockets. Dysbiosis occurs, the severity of which corresponds to the severity of periodontal lesions. In this regard, a promising direction in the development of new methods ofcomplex treatment of periodontitis is the use of bacterial preparations, the active principle of which are strains of representatives of normal microflora.The aim of the study was to study the effect of the method of treating chronic periodontitis, including the use of a probiotic and low-intensity laser radiation, on the content of lactobacilli in the contents of periodontal pockets.Materials and methods. The object of the study was 100 patients diagnosed with chronic generalized periodontitis of moderate and moderate severity.Results. The inclusion in the complex treatment of patients with chronic periodontitis against the background of somatic pathology of local application of the probiotic in combination with low-intensity laser radiation contributes to the normalization of the microecology of periodontal pockets.
Split Notochord Syndrome in the First Trimester of Pregnancy
Authors: Лазаревич А.А. 
Published: February 2022

Цель исследования. Описать ультразвуковые и патоморфологические признаки синдрома расщепления хорды у плода в первом триместре беременности.Материалы и методы. Сонография проводилась на аппарате Voluson 730 Expert с использованием трансабдоминального (4–8 МГц) датчика. Нозологический диагноз установлен по результатам патоморфологического исследования плода в I триместре.Результаты. Основными ультразвуковыми (УЗ) признаками синдрома расщепления хорды явились кистозное образование в грудной клетке плода и аномалии позвоночника, включающие полупозвонки, расщепление, деформацию, ограниченную визуализацию позвонков.Выводы. Синдром расщепления хорды является наиболее частой этиологической причиной кистозных образований в грудной клетке плода. При пренатальном выявлении кистозного образования в грудной клетке плода следует провести тщательное обследование позвоночника на предмет выявления аномалий позвонков, что будет способствовать более точной диагностике синдрома расщепления хорды.
Purpose. To explore the ultrasound and pathomorphological signs of split notochord syndrome in the fetus of the first trimester of pregnancy.Materials. Sonography was performed on a Voluson 730 Expert using a transabdominal (4–8 MHz) sensor. The nosological diagnosis is established by the result of pathomorphological and histological studies in the first trimester.Results. We present sporadic case of split notochord syndrome in the fetus of the first trimester. The ultrasound signs were intra-thoracic cyst with vertebral anomalies including hemivertebrae, missing vertebrae and central vertebral body narrowing.Conclusions. Split notochord syndrome is the most common etiology of fetal chest cystic lesions. Detailed examination of the vertebrae when a fetal cystic chest mass is identified on prenatal ultrasound may lead to improved detection and diagnosis of split notochord syndrome, which is important for more accurate prenatal counseling.
The Use of Chophytol in the Complex Treatment of Pyelonephritis in Pregnant Women
Authors: Пересада О.А. , Зновец Т.В. , Шиптенко И.Л. , Котова Г.С. , Милюк Н.С. , Юркевич М.В. , Шереметьева Л.З. , Соколовская М.Н. 
Published: February 2022

Изучено влияние препарата Хофитол в комплексной терапии на динамику клинико-лабораторных показателей при пиелонефрите беременных, исходы родоразрешения и состояние плода. Использование препарата Хофитол в комплексной терапии пациентов с пиелонефритом беременных способствовало достоверному снижению ряда повышенных показателей сыворотки крови (уровней креатинина и мочевины, трансаминаз, билирубина и его фракций, ЩФ и др.). При применении Хофитола не наблюдались аллергические и другие побочные реакции, отмечалась хорошая переносимость.
The effect of Chophytol in complex therapy on the dynamics of clinical and laboratory parameters in pregnant women with pyelonephritis, the outcomes of delivery and the condition of the fetus was studied. The use of Chophytol in the complex therapy of pregnant women with pyelonephritis led to a significant decrease of a number of elevated blood serum parameters (levels of creatinine and urea, transaminases, bilirubin and its fractions, alkaline phosphatase, etc.). The use of Chophytol had no allergic and other side reactions, and good tolerability was noted.
Diagnostic Value of Intima-Media Complex in Assessing Remodelling and Atherosclerotic Features in Patients with Rheumatoid Arthritis
Authors: Саидова М.М. 
Published: February 2022

Введение. Сердечно-сосудистые заболевания (ССЗ) являются одной из ведущих причин смерти и инвалидизации во всем мире. По данным Европейского общества кардиологов, «…ежегодно от ССЗ умирают более 4 миллионов человек, из которых 1,4 миллиона моложе 75 лет, что составляет 45% всех смертей…». По данным крупных исследовательских центров, смертность от кардиоваскулярной патологии (КВП) чаще встречается у пациентов с ревматоидным артритом (РА), чем среди населения в целом.Цель. Оценить параметр толщины интима-медиа (ТИМ) сонных артерий как раннего предиктора развития атеросклероза у пациентов с ревматоидным артритом (РА).Материалы и методы. В исследование были включены 89 пациентов с РА в возрасте 35–60 лет. ТИМ сонных артерий определяли методом допплерографии в В-режиме. Результаты. Результаты, полученные при определении толщины комплекса интима-медиа (КИМ) общей сонной артерии у пациентов с РА, показали 0,98±0,18 мм в правой сонной артерии и 1,01±0,18 мм в левой сонной артерии. Патологическое увеличение этого показателя (>0,9 мм) было выявлено более чем у половины пациентов в исследовании – 49 (55,1%) случаев, КИМ составил 1,13±0,07 мм в правой сонной артерии и 1,16±0,07 мм в левой сонной артерии.Заключение. Оценка параметров ТИМ сонных артерий как раннего предиктора развития атеросклероза у пациентов с ревматоидным артритом дает возможность своевременно выявить сердечно-сосудистый риск и разработать меры профилактики и лечения.
Introduction. Cardiovascular disease (CVD) is one of the leading causes of death and disability worldwide. According to the European Society of Cardiology, "...more than 4 million people die each year from CVDs, of which 1.4 million are under 75 years old, accounting for 45% of all deaths...". According to major research centres, cardiovascular mortality (CVD) is more common in patients with rheumatoid arthritis (RA) than in the general population.Purpose. To assess carotid artery intima-media thickness (IMT) as an early predictor of atherosclerosis in patients with rheumatoid arthritis (RA).Materials and methods. The study included 89 patients with RA aged 35–60 years. Carotid artery IMT was determined by B-mode Doppler.Results. The analysis of the results obtained by determining the intima-media complex (IMC) thickness of the common carotid artery in patients with RA was 0.98±0.18 mm in the right carotid artery and 1.01±0.18 mm in the left carotid artery. An abnormal increase in this index (>0.9 mm) was detected in more than half of the patients in the study – 49 (55.1%) cases, and the CMR was 1.13±0.07 mm in the right carotid artery and 1.16±0.07 mm in the left carotid artery.Conclusion. Evaluation of carotid artery IMT parameters as an early predictor of atherosclerosis in rheumatoid arthritis patients allows timely assessment of cardiovascular risk and development of preventive and treatment measures.
Modern Ideas about the Diagnostic Significance and Mechanisms of Increasing the Levels of Cardiac Troponins in Arterial Hypertension in Human Biological Fluids
Authors: Чаулин А.М. , Дупляков Д.В. 
Published: February 2022

На фоне улучшения чувствительности лабораторных методов детекции сердечных тропонинов (cTn) открылись новые диагностические возможности для их применения в клинической практике. Новые высокочувствительные методы определения тропонинов (hs-cTn) позволяют выявлять даже самые незначительные повреждения кардиомиоцитов при многих сердечных и системных заболеваниях, и степень повышения hs-cTn, как правило, имеет значительную диагностическую и/или прогностическую ценность. Многие из таких заболеваний, в частности артериальная гипертензия (АГ), могут протекать латентно и в последующем часто приводить к возникновению ряда опасных и тяжелых осложнений в виде острого инфаркта миокарда, сердечной недостаточности, инсульта и др. Поэтому раннее выявление пациентов с АГ, имеющих повышенный риск возникновения данных осложнений, будет иметь большое значение для улучшения лечебно-профилактических мероприятий в клинической практике. В данной статье подробно обсуждаются возможность использования и диагностическое значение повышенных уровней hs-cTn в биологических жидкостях у пациентов, страдающих АГ. Отдельное внимание уделено механизмам повышения hs-cTn при АГ в биологических жидкостях человека.
Against the background of improving the sensitivity of laboratory methods for detecting cardiac troponins (cTn), new diagnostic opportunities have opened up for their use in clinical practice. New highly sensitive methods for determining troponins (hs-cTn) make it possible to detect even the most insignificant damage to cardiomyocytes in many cardiac and systemic diseases, and the degree of increase in hs-cTn, as a rule, has significant diagnostic and/or prognostic value. Many of these diseases, in particular arterial hypertension (AH), can occur latently and subsequently often lead to a number of dangerous and severe complications in the form of acute myocardial infarction, heart failure, stroke and others. Therefore, earlier identification of patients with hypertension who have an increased risk of these complications will be important for improving therapeutic and preventive measures in clinical practice. This article discusses in detail the possibility of using and the diagnostic value of elevated levels of hs-cTn in biological fluids in patients suffering from AH. Special attention is paid to the mechanisms of increasing hs-cTn in hypertension in human biological fluids.