bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lot-to-lot variation and verification
Authors: Loh Tze Ping , Markus Corey , Tan Chin Hon , Tran Mai Thi Chi , Sethi Sunil Kumar , Lim Chun Yee 
Published: November 2022

Abstract
Lot-to-lot verification is an integral component for monitoring the long-term stability of a measurement procedure. The practice is challenged by the resource requirements as well as uncertainty surrounding experimental design and statistical analysis that is optimal for individual laboratories, although guidance is becoming increasingly available. Collaborative verification efforts as well as application of patient-based monitoring are likely to further improve identification of any differences in performance in a relatively timely manner. Appropriate follow up actions of failed lot-to-lot verification is required and must balance potential disruptions to clinical services provided by the laboratory. Manufacturers need to increase transparency surrounding release criteria and work closer with laboratory professionals to ensure acceptable reagent lots are released to end users. A tripartite collaboration between regulatory bodies, manufacturers, and laboratory medicine professional bodies is key to developing a balanced system where regulatory, manufacturing, and clinical requirements of laboratory testing are met, to minimize differences between reagent lots and ensure patient safety. Clinical Chemistry and Laboratory Medicine has served as a fertile platform for advancing the discussion and practice of lot-to-lot verification in the past 60 years and will continue to be an advocate of this important topic for many more years to come.
Ultrasonic-induced reversible blood–brain barrier opening: Safety evaluation into the cellular level
Authors: Wang Mengxin , Guo Shuyuan , Lin Bingling , Lv Tao , Zhang Zhuxia , Hu Die , Hu Azhen , Xu Bingxuan , Qi Yulong , Liu Li , Cheng Guanxun , Chen Yun , Zheng Tingting 
Published: November 2022

Abstract
An important function of the blood–brain barrier (BBB) is to protect the central nervous system and maintain its homeostasis, but it is also a major barrier to the intervention and treatment of neurological diseases. Our study aimed at opening the BBB using a noninvasive method, focused ultrasound, screening for 16 different parameter combinations of frequency, peak voltage (Ppeak) and irradiation time. Comparing the results of hematoxylin–eosin staining, serum oxidative damage factor and TUNEL staining under various conditions, we obtained a parameter combination that did not lead to oxidative stress injury and apoptosis: 0.8 mHz + 900 mVpp + 90 s. It will be used as a safety parameter for BBB opening treatment of Parkinson’s disease in our subsequent experiments. In addition, the closing time after the BBB opening was verified in magnetic resonance imaging contrast examination and at the tissue level. It is worth mentioning that, different from previous studies, we focused on damage assessment at cellular and molecular levels.
Nitrogen removal characteristics of wet–dry alternative constructed wetlands
Authors: Chen Xinyong , Tian Zaifeng , Zhu Jing , Wu Yihong , Zhao Qi 
Published: November 2022

Abstract
Dry–wet alternate constructed wetland is an effective method to remove nitrogen elements in the tail water of sewage treatment plant. According to the reaeration mechanism of wet–dry alternative constructed wetland, the denitrification effect and influence characteristics of the dry–wet alternate constructed wetland on the tail water of sewage treatment plant were studied under low temperature. The results showed that the removal rates of each nitrogen element in the constructed wetland reached 20–40% with the dry–wet alternate time at 10°C. Under the influence of dry–wet alternation of constructed wetland, dissolved oxygen (DO) was significantly correlated with the dry–wet alternation time (p < 0.05), and DO was correlated with each nitrogen element removal rate (p < 0.05), which means constructed wetlands use alternate dry and wet operation, which can significantly affect the content of DO and nitrogen removal efficiency in constructed wetlands, providing a technical basis for regulating the operation effect of constructed wetland ecosystems.
Sunflower is the main oil crop in Ukraine
Authors: Chekhova Irina 
Published: November 2022

Abstract
The article is devoted to the analysis of production volumes and efficiency of sunflower cultivation in Ukraine. It is shown that sunflower occupies more than 70% of the total acreage under oil crops. Attention is focused on the fact that the dominance of sunflowers in the structure of the production of oil crops provides this crop with a special role in the agricultural market of Ukraine. The dynamics of sown areas, gross harvests and the level of productivity of sunflowers in Ukraine for the period 2018–2020 were analyzed. The effectiveness of sunflower production was studied in terms of forms of management of agrarian formations and by the amount of land in use. It has been established that the most effective cultivation of sunflowers is carried out by agricultural enterprises with a land area of more than 2 thousand hectares. Cost calculations and their structure for growing 1 ha of marketable sunflower in 2021 are presented. The volumes and structure of the directions of consumption of marketable sunflower seeds in Ukraine are shown. Practical recommendations for improving the process of sunflower production are proposed, taking into account the balance of supply and demand for marketable products.
Linear isomorphic spaces of Cesàro–Nörlund operator, their duals and matrix transformations
Authors: Singh Uday Pratap , Jasrotia Swati , Raj Kuldip 
Published: November 2022

Abstract
In this article, we introduce and study sequence spaces of Cesàro–Nörlund operators of order n associated with a sequence of Orlicz functions.
We obtain some topological properties and Schauder basis
of these sequence spaces. Moreover, we compute the α-, β- and γ-duals and the matrix transformations of these newly formed sequence spaces. Finally, we prove that these sequence spaces are of Banach–Saks type p and have a weak fixed-point property.
An iterative technique for solving split equality monotone variational inclusion and fixed point problems
Authors: Mewomo Oluwatosin Temitope , Ogbuisi Ferdinard Udochukwu 
Published: November 2022

Abstract
The purpose of this paper is to introduce an iterative algorithm for approximating the solution of the split equality monotone variational inclusion problem (SEMVIP) for monotone operators, which is also a solution of the split equality fixed point problem (SEFPP) for strictly pseudocontractive maps in real Hilbert spaces. We establish the strong convergence of the sequence generated by our iterative algorithm. Our result complements and extends some related results in literature.
Inverse problem for integro-differential Kelvin–Voigt equations
Authors: Khompysh Khonatbek , Nugymanova Nursaule K. 
Published: November 2022

Abstract
In this paper, the existence and uniqueness of a strong solution of the inverse problem of determining a coefficient of right-hand side of the integro-differential Kelvin–Voigt equation are investigated. The unknown coefficient that we search defends on space variables.
Additional information on a solution of the inverse problem is given here as an integral overdetermination condition. The original inverse problem is reduced to study an equivalent inverse problem with homogeneous initial condition. Then the equivalences of the last inverse problem to an operator equation of second kind is proved.
We establish the sufficient conditions for the unique solvability of the operator equation of second kind.
A Hölder stability estimate for a 3D coefficient inverse problem for a hyperbolic equation with a plane wave
Authors: Klibanov Michael V. , Romanov Vladimir G. 
Published: November 2022

Abstract
A 3D coefficient inverse problem for a hyperbolic equation with
non-overdetermined data is considered. The forward problem is the Cauchy
problem with the initial condition being the delta function concentrated at a
single plane (i.e. the plane wave). A certain associated operator is written
in finite differences with respect to two out of three spatial variables,
i.e. “partial finite differences”. The grid step size is
bounded from below by a fixed number. A Carleman estimate is applied to
obtain, for the first time, a Hölder stability estimate for this
problem. Another new result is an estimate from below the amplitude
of the first term of the expansion of the solution of the forward problem
near the characteristic wedge.
Removal of pregnancy categories and likelihood of prescribing: a randomized trial
Authors: Robinson Angela , Futterman Itamar D. , Atallah Fouad , Weedon Jeremy , Chen Yi-Ju Amy , Apostol Radu , Minkoff Howard 
Published: November 2022

Abstract

Objectives
To assess the degree to which removal of FDA’ Pregnancy Categories (PC) of medications (A, B, C, and D) from labeling, affects the likelihood that providers will prescribe those medications.

Methods
Over a one-year period a convenience sample of providers was recruited into a randomized, survey-based, study. Two versions of the survey were randomly distributed; version 1 presented clinical vignettes, drug information, and PC, while version 2, presented the identical information without the PC. Respondents were asked to estimate their likelihood of prescribing the drug. A mixed linear model was constructed, with likelihood of prescription as the dependent variable, treated as interval-scaled.

Results
Out of 169 surveys given out, 162 (96%) were returned. Simple effects analysis showed that the presence of PC letter significantly affected the decision to prescribe category B (p<0.001) and C drugs (p=0.008) but not the A or D. Participants were significantly less likely to prescribe class B and C drugs when the letters were not available for review. These findings remained significant even when controlling for covariates (p=0.001).

Conclusions
When a PC letter is absent on labeling, physicians were less likely to use category B and C drugs, the most common medications prescribed in pregnancy.
Dictionaries as instruments of exclusion and inclusion: some South African dictionaries as case in point
Authors: Gouws Rufus H. 
Published: November 2022

Abstract
As utility tools dictionaries should convey data in an impartial way. Lexicographers should not impose either their subjective view or some prevailing ideologies on the users of the dictionary. This paper focuses on aspects of exclusion and othering in some South African dictionaries. Different types of exclusion in different types of dictionaries are shown but it is also shown how dictionaries contribute to processes of inclusion. The treatment of a single offensive racist word in different dictionaries is discussed and the lack of countering the insulting impact of the use of the word is criticized. A positive response to this problem by means of a policy for the treatment of sensitive words is also discussed.
Sprachliche Ausgrenzung in der Lexikographie des Tschechischen
Authors: Vachková Marie 
Published: November 2022

Abstract
The article describes in a chronological overview the lexicographical processing of the entry cikán (‘Gypsy’) and its derivatives which are now perceived as more or less discriminatory and establishes historical and political references. Central attention is directed to the dictionary articles from the Concise dictionary of the Czech language: the author explores the connections between the dictionary articles and the tenor of the excerpted material which is available online as a digitized card index. In this way one can partly determine to what extent one can infer an evidence of a prejudice that has accompanied the presence of the Sinti and Roma on the Bohemian / Czech or Moravian territory for centuries until today.
Critical buckling loads of embedded perforated microbeams with arbitrary boundary conditions via an efficient solution method
Authors: Uzun Büşra , Civalek Ömer , Yaylı Mustafa Özgür 
Published: November 2022

Abstract
In the present work, the small size effects on stability properties of perforated microbeams under various types of deformable boundary conditions are studied considering the Fourier sine series solution procedure and a mathematical procedure known as Stokes’ transformation for the first time. The main benefit of the present method is that, in addition to considering both the gradient elasticity and the size effects, the kinematic boundary conditions are modeled by two elastic springs as deformable boundary conditions. The deformable boundary conditions and corresponding stability equation are described using the classical principle which are then used to construct a linear system of equations. Afterward, an eigenvalue problem is adopted to obtain critical buckling loads. The correctness and accuracy of the present model are demonstrated by comparing results with those available from other works in the literature. Moreover, a numerical problem is solved and presented in detail to show the influences of the perforation properties, geometrical, and the variation of small-scale parameters and foundation parameters on the stability behavior of the microbeams. In addition, according to the best knowledge of the authors, there is no study in the literature that examines the buckling behavior of perforated microbeams on elastic foundation with the gradient elasticity theory.
Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stem‐like cells
Authors: Liu Zhen , Shan Shan , Yuan Zixin , Wu Fengying , Zheng Ming , Wang Ying , Gui Jun , Xu Wei , Wang Chunhong , Ren Tao , Wen Zhenke 
Published: November 2022

AbstractWhile previous studies have identified cancer stem‐like cells (CSCs) as a crucial driver for chemoresistance and tumor recurrence, the underlying mechanisms for populating the CSC pool remain unclear. Here, we identify hypermitophagy as a feature of human lung CSCs, promoting metabolic adaption via the Notch1‐AMPK axis to drive CSC expansion. Specifically, mitophagy is highly active in CSCs, resulting in increased mitochondrial DNA (mtDNA) content in the lysosome. Lysosomal mtDNA acts as an endogenous ligand for Toll‐like receptor 9 (TLR9) that promotes Notch1 activity. Notch1 interacts with AMPK to drive lysosomal AMPK activation by inducing metabolic stress and LKB1 phosphorylation. This TLR9‐Notch1‐AMPK axis supports mitochondrial metabolism to fuel CSC expansion. In patient‐derived xenograft chimeras, targeting mitophagy and TLR9‐dependent Notch1‐AMPK pathway restricts tumor growth and CSC expansion. Taken together, mitochondrial hemostasis is interlinked with innate immune sensing and Notch1‐AMPK activity to increase the CSC pool of human lung cancer.
ПРОМЫШЛЕННЫЕ ПРЕДПРИЯТИЯ В УСЛОВИЯХ ЦИФРОВЫХ ТРАНСФОРМАЦИЙ (НА ПРИМЕРЕ ПЕРМСКОГО КРАЯ)
Authors: Рожков Евгений Викторович 
Published: November 2022

Целью исследования является анализ основных нормативных документов по внедрению цифровизации и цифровых трансформаций для промышленных предприятий.
Методологическая база исследования представляет анализ материалов, характеризующих экспертные оценки прогнозов положительных последствий по усовершенствованию механизмов трансформации предприятий на примере одного региона.
Результаты исследования определили необходимость разработки документов на основании федеральной нормативно-правовой базы документов для промышленности. Должны быть разработаны такие документы, как Концепции развития цифровой экономики промышленности регионов и нормативные документы в сфере «Цифра».
Перспективы исследования. Вклад проведённого исследования в развитие процессов цифровизации промышленности и внедрения цифровых платформ состоит в уточнении имеющейся нормативно-правовой базы. Развитие нормативной базы по цифровизации — это сегодняшняя необходимость развития промышленности.
СОЦИАЛЬНО-ФИЛОСОФСКИЕ АСПЕКТЫ ПАЛЛИАТИВНОЙ ПОМОЩИ В ЦЕННОСТНЫХ КООРДИНАТАХ РОССИЙСКОГО ОБЩЕСТВА
Authors: Агансон Герман Игоревич 
Published: November 2022

Цель исследования заключается в рассмотрении социально-философских аспектов паллиативной помощи.
Методология исследования. Изучение особенностей паллиативной помощи в рамках аксиосферы требует осуществления междисциплинарного подхода, что обусловливает необходимость применения комплекса методов в проведении исследования. Предпочтительными становятся индуктивно-дедуктивный метод, методы анализа и синтеза, сравнения и сопоставления, а также философской рефлексии.
Результаты исследования. Доказано, что паллиативная помощь обнаруживает тенденцию к интеграции подходов различных дисциплин: медицины, психологии, социальной философии. Одна из центральных целей паллиативной помощи как наиболее философской сферы из всех существующих медицинских областей состоит в организации пространства взаимопомощи, «продления» и усиления личности инкурабельного пациента в других. Аксиосфере современного российского общества также не противоречит ведущая идея паллиативной помощи — максимально возможная активная жизнь пациента вне намерения продления или сокращения срока его жизни. Принципы, составляющие основу паллиативной помощи, имеют общефилософский и гуманистический характер — это справедливость, уважение к пациенту, автономия прав больного, его достоинство. Отмечается, что сильнейшая боль и страдания оказывают существенное воздействие на пациента и способны не только лишить его собственного достоинства, но и привести к мысли о предпочтительности смерти. Однако системно и адекватно осуществляемая паллиативная помощь лишает эвтаназию всякого смысла.
Перспективы исследования заключаются в дальнейшем анализе паллиативной помощи в социально-флоксовом контексте в целях ее развития как социальной практики.
КОНЦЕПТУАЛЬНЫЕ ИСТОКИ АНТРОПОЛОГИИ Э. ФРОММА
Authors: Поломошнов Андрей Федорович , Котлярова Елена Александровна 
Published: November 2022

Целью исследования является анализ отношения Э. Фромма к идейным источникам его гуманистического психоанализа: фрейдизму, марксизму и экзистенциализму в контексте его замысла теоретического синтеза марксизма и фрейдизма.
Методологическую базу исследования представляют работы Э. Фромма, посвященные анализу социально-философских и антропологических концепций З. Фрейда, экзистенциализма и марксизма, а также современные исследования истоков антропологии Э. Фромма.
Результаты исследования. В статье исследуется отношение антропологии Э. Фромма к ее основным идейным источникам: фрейдизму, марксизму и экзистенциализму. Исследование проводится в двух планах. С одной стороны, рассматриваются собственные характеристики этих источников самим мыслителем. С другой стороны, анализируются взгляды современных исследователей творчества Э. Фромма с точки зрения отношения его антропологии к фрейдизму, марксизму и экзистенциализму. В первом плане Фромм, упрекая фрейдизм в акцентуации биологических влечений в природе человека и этическом релятивизме, признает бессознательную психическую энергию как основу развития личности. Экзистенциализм мыслитель критикует за абсолютизацию экзистенциальных противоречий существования личности. Для Фромма эти противоречия — не конец, а начало антропологии. Говоря о марксизме, мыслитель, опираясь на первоисточники, реконструирует оригинальные идеи антропологии К. Маркса, многие из которых он целиком разделяет. Он стремится дополнить марксизм психологическим анализом социальной жизни личности. Во втором плане, опираясь на современные исследования истоков психоаналитической антропологии Э. Фромма, авторы приходят к выводу о том, что мыслителю не удался эффективный теоретический синтез марксизма и психоанализа. У мыслителя не получилось преодолеть им же установленные экзистенциальные дихотомии в природе человека, а также найти разрешение исторических дихотомий, в частности проблемы тотального отчуждения личности в современном мире.
Перспективы исследования заключаются в установлении трудностей и ограничений, с которыми столкнулся Э. Фромм при попытке синтеза фрейдизма и марксизма, а также в актуализации конструктивного потенциала развития психоаналитической антропологии Э. Фромма в контексте современных вызовов гуманизму.
Elusive Silver Lining: Caring for Patients in the HIV/AIDS “War Zone”. How Did Nurses Sustain It? Benefit-Finding Analysis
Authors: G.A. Jacob Carl , Lagacé-Roy Daniel , Lussier-Duynstee Patricia 
Published: November 2022

Using a review of literature consisting of peer-reviewed articles and grey literature, this paper presents a narrative and graphic representation of the key concepts underpinning the benefits nurses perceived deriving from caring for patients during the HIV/AIDS pandemic. Our review indicates that benefits were seldom the focus of the literature and were mostly integrated within documents pertaining to the negative aspects of caring for these patients. In such a context, this research identified self-enhancement benefits in three domains (work benefits, work attributes, and work ethos), and self-actualization benefits in three domains (relationships, transformation, and humanity). During the COVID-19 pandemic, researchers are once again enticed to write scientific literature about the impact of caring in a “war zone”. Using the underpinning concepts identified through the benefit-finding research in the context of the HIV/AIDS pandemic, researchers could identify the many perceived benefits nurses derive from caring for infected patients during this pandemic.
ELECTRONIC VOTING: A COMMUNICATION NETWORK THAT LINKS STATE AND SOCIETY
Authors: Fedorov Vladislav I. 
Published: November 2022

Aim.To develop various approaches to the identification and critical understanding of the electronic voting as a new mechanism of political activity.Methodology.The research is based on general scientific methods, such as comparative method of extrapolation and forecasting. In addition, we use systemic approach and method of participant observation.Results.In our research work, we have introduced our own electronic voting model as a communication network that links the state and society. Its goal is to escalate people’s conventional political activity with the help of close control over the constituency.Research implications.The results of our work contribute to the development of theories touching upon the problems of information-oriented society and political communication.