bluuebunny/crossref_metadata_2025_split huggingface dataset:
In search of the perfect tan: Chemical activity, biological effects, business considerations, and consumer implications of dihydroxyacetone sunless tanning products
Authors: Turner Josh , O’Loughlin Danielle A. , Green Phill , McDonald Tom O. , Hamill Kevin J. 
Published: April 2022

AbstractAs the desire and popularity of a tanned appearance continues, the social effects of UV‐free tanning are becoming more important. Dihydroxyacetone (DHA) has seen extensive use as the main tanning agent in sunless tanners. The DHA‐induced tan is a result of brown melanoidins formed by a non‐enzymatic Maillard reaction between DHA and amino acid species found in the stratum corneum. DHA, thereby, provides a safer route to a tanned appearance compared with exposure to ultraviolet radiation. However, DHA is a highly reactive molecule, posing a multitude of challenges for potential product formulations. With their increased use, the safety considerations of topically applied DHA tanners have been investigated. Many different vehicles have been used for topical delivery of DHA, and they are becoming increasingly multifunctional. This review provides a holistic overview of dihydroxyacetone sunless tanning products.
Stream or discharge? Analysing hydrosocial relations in the Waimapihi Stream to innovate urban water politics
Authors: McLean Sylvie 
Published: April 2022

AbstractIn Te Whanganui‐a‐Tara Wellington, Aotearoa New Zealand, 95% of the length of urban streams are piped and buried, leaving them hidden. Technocratic management regimes separate streams into discrete parts, and thus overlook important relationships that can improve or maintain the state of streams. This paper takes a hydrosocial perspective on urban streams, exploring connections between water flow, infrastructure, and social structures and institutions to consider the buried Waimapihi Stream. Drawing on interviews, it examines implications of the Waimapihi's legislative status and management for its headwaters at the Waimapihi Reserve and the stormwater piped section, and considers the potential for daylighting the piped section.
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques
Authors: Holdcraft Robert W. , Graham Melanie J. , Bemrose Melissa A. , Mutch Lucas A. , Martis Prithy C. , Janecek Jody L. , Hall Richard D. , Smith Barry H. , Gazda Lawrence S. 
Published: April 2022

AbstractAlthough human islet transplantation has proven to provide clinical benefits, especially the near complete amelioration of hypoglycemia, the supply of human islets is limited and insufficient to meet the needs of all people that could benefit from islet transplantation. Porcine islets, secreting insulin nearly identical to that of human insulin, have been proposed as a viable supply of unlimited islets. Further, encapsulation of the porcine islets has been shown to reduce or eliminate the use of immunosuppressive therapy that would be required to prevent rejection of the foreign islet tissue. The goal of the current study was to determine the long‐term safety and efficacy of agarose encapsulated porcine islets (macrobeads) in diabetic cynomolgus macaques, in a study emulating a proposed IND trial in which daily exogenous insulin therapy would be reduced by 50% with no loss of glucose regulation. Four of six animals implanted with macrobeads demonstrated ≥ 30% reduction in insulin requirements in year 1 of follow‐up. Animals were followed for 2, 3.5, and 7.4 years with no serious adverse events, mortality or evidence of pathogen transmission. This study supports the continued pursuit of encapsulated porcine islet therapy as a promising treatment option for diabetes mellitus.
U-Pb dating of oil charge in superimposed basins: A case study from the Tarim Basin, NW China
Authors: Chen Jiaxu , Guo Xiaowen , Tao Ze , Cao Zicheng , Wang Bin , Zhang Xuyou , Xu Hao , Zhao Jian-xin 
Published: April 2022

Abstract
Direct dating of oil charge in superimposed basins is essential to understanding the evolutionary histories of petroleum systems, especially in sedimentary basins with complicated tectonic evolution and thermal histories. Based on analyses of different phases of calcite veins and primary oil inclusions, episodes of oil charge were determined by laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) in situ U-Pb dating of calcite veins from an Ordovician reservoir within the Tahe Oilfield of the Tarim Basin, NW China. This basin has been subjected to multiple uplifts and erosions and repeated oil charges. The U-Pb dating results indicate that the first phase of oil charge occurred from 329.7 ± 1.6 Ma to 308.1 ± 4.1 Ma, and the second phase occurred from 249.3 ± 2.6 Ma to 220.5 ± 7.3 Ma. The timing of oil charge determined by fluid inclusion analysis alone can lead to great uncertainties due to the existence of multiple phases of oil charge and complex thermal evolution in superimposed basins. Our study demonstrates that U-Pb dating of calcite veins originating from the reservoirs offers a unique solution to determining the oil charge history, which avoids the multi-solution uncertainties in the timing of oil charge inferred from fluid inclusion analysis in superimposed basins.
Vacuum (meta-)stability in the $$\mu \nu $$SSM
Authors: Biekötter Thomas , Heinemeyer Sven , Weiglein Georg 
Published: April 2022

AbstractWe perform an analysis of the vacuum stability of the neutral scalar potential of the $$\mu $$
μ
-from-$$\nu $$
ν
Supersymmetric Standard Model ($$\mu \nu $$

μ
ν

SSM). As an example scenario, we discuss the alignment without decoupling limit of the $$\mu \nu $$

μ
ν

SSM, for which the required conditions on the Higgs sector are derived. We demonstrate that in this limit large parts of the parameter space feature unphysical minima that are deeper than the electroweak minimum. In order to estimate the lifetime of the electroweak vacuum, we calculate the rates for the tunneling process into each unphysical minimum. We find that in many cases the resulting lifetime is longer than the age of the universe, such that the considered parameter region is not excluded. On the other hand, we also find parameter regions in which the electroweak vacuum is short-lived. We investigate how the different regions of stability are related to the presence of light right-handed sneutrinos. Accordingly, a vacuum stability analysis that accurately takes into account the possibility of long-lived metastable vacua is crucial for a reliable assessment of the phenomenological viability of the parameter space of the $$\mu \nu $$

μ
ν

SSM and its resulting phenomenology at the (HL)-LHC.
Dose-Dependent Efficacy of Umbelliferone and Gelatin-Coated ZnO/ZnS Core-Shell Nanoparticles: A Novel Arthritis Agent for Severe Knee Arthritis
Authors: Zheng Yongzhi , Lakshmanan Sivalingam 
Published: April 2022

Rheumatoid arthritis (RA) is a well-known autoimmune disorder that affects 1% of the global population. Zinc (Zn) is crucial for bone homeostasis, when compared with normal human bone, Zn level found to be decreased in RA patients and collagen-induced arthritis (CIA) rats. Notably, Zn-based medicinal products play a prominent role in reducing disease symptoms and acute side effects of patients with bone-related diseases. In this study, we report the clinical efficiency of gelatin- (Gel-) coated ZnO-ZnS core-shell nanoparticles (CSNPs) with umbelliferon (Uf) drug (Uf-Gel-ZnO-ZnS CSNPs) on the normal and CIA-induced Wistar rats. The formed ZnO-ZnS CSNPs are spherical in shape, with an average particle diameter of

150
±
7

nm

. It showed strong cytocompatibility when tested on L929 and foreskin fibroblasts (BJ) cells by MTT assay. While comparing with free Uf, various doses (2.5 and 5 mg) of Uf-Gel-ZnO-ZnS CSNPs showed strong inhibition of CIA by attenuated proinflammatory cytokines such as interleukin-1β, IL-6, PEG2, and IL-17. The Uf-Gel-ZnO-ZnS CSNPs show more effectiveness in reducing joint swelling and also increase the level of antioxidant enzymes. In addition, CSNPs significantly reduced the infiltration of inflammatory cells in the knee joint. Thus, the current study concludes that Uf-Gel-ZnO-ZnS CSNPs feasibly reduce the incidence of arthritis in a dose-dependent manner by attenuation of inflammation.
A Clinical Audit of Cross-Infection Control Practices in Orthodontic Setups During the COVID-19 Scenario
Authors: Thakur Agrima , Sowmya Jangam , Chitra Prasad 
Published: April 2022

Background: The COVID-19 pandemic has caused many changes in the practice of orthodontics, with the main focus being prevention of cross-infection. Clinical audits can help assess the extent to which practices/practitioners adhere to standard cross-infection control protocols, thereby providing scope for improvement resulting in better treatment outcomes. Objective: Phase 1—to investigate the type of cross-infection control procedures being followed by orthodontic residents of 5 dental institutes in Hyderabad city and compare them to recommended guidelines. Phase 2—after identification of the shortcomings, analyzing how re-education and revision of guidelines can lead to improvements in cross-infection prevention protocols. Methodology: Orthodontic residents of 5 dental institutes were observed with regard to their routine infection control practices, which were compared to a set standard. A second audit cycle was conducted on the same clinicians after a seminar where they were encouraged to work on shortcomings at their workplace. The results from the 2 audit cycles were then compared to assess differences. Results and Conclusion: While most clinicians were aware of the recommended cross-infection control guidelines, few steps were neglected while in practice. Comparisons between the 2 audit cycles revealed definite improvements.
Messaging, Posting, and Browsing: A Mobile Experience Sampling Study Investigating Youth’s Social Media Use, Affective Well-Being, and Loneliness
Authors: Karsay Kathrin , Matthes Jörg , Schmuck Desirée , Ecklebe Sarah 
Published: April 2022

Employing a mobile experience sampling design, we investigated in the present study how different types of mobile social media use relate to young individuals’ momentary affective well-being and momentary loneliness. We differentiated between three types of social media use: Messaging, posting, and browsing. Moreover, we studied fear of missing out (FoMO) as a moderating variable. We collected data from 79 middle and late adolescents ( M age = 17.55 years, SD = 1.29; 59% girls) yielding 956 momentary assessments. The results showed that messaging and posting were positively related to affective well-being, while browsing was associated with higher levels of loneliness. Furthermore, some of the relations between social media use, affective well-being, and loneliness were also moderated by FoMO. Our results highlight the need to differentiate between different types of social media use, to include individual predispositions, and to apply methods that account for daily fluctuations in psychological well-being when studying the complex relationship between youth’s mobile social media use and well-being.
The effects of social, familial, and economic stress on social workers working with disabled individuals
Authors: Alsabti Khawlah A 
Published: April 2022

Summary This study aimed to employ a social survey method to define the social, familial, and economic stresses experienced by a sample of 135 Saudi social workers who work with people with disabilities. It also aimed to understand the impact of these stresses on the degree of burnout these workers experienced in the following three dimensions: emotional exhaustion, depersonalization, and personal accomplishment. Findings We found that the degree of social, familial, and economic stress among social workers was moderate, whereas the degree of depersonalization was high; emotional exhaustion was medium; and personal accomplishment was low. We found a medium proportional correlation between the total stress experienced by a social worker and the emotional exhaustion they were likely to experience, which had a weak inverse correlation with personal accomplishment. Social workers’ total stress predicted their burnout to be 18.7% in terms of emotional exhaustion, 19.6% for depersonalization, and 7.5% for personal accomplishment. These predicted values also differed with regards to each focus. There was no correlation between workers’ burnout and the quantitative demographic variations. Applications The social and familial stresses encountered by social workers working with disabled individuals should be considered in order to map the causes of their suffering and, ultimately, to establish ways of alleviating the severity of the burnout they experience. Finally, there was evidence to support the idea that a review of their monthly salaries might serve as a solution to burnout.
Hsa_circ_0030042 Facilitates the Proliferation and Migration of Vascular Smooth Muscle Cells via the miR-514a-3p/FOXO1 Axis
Authors: Ma Ji , Liu Jia , Li Tengfei , Ren Jianzhuang 
Published: April 2022

Purpose: Circular RNA (circRNA) has been proved to play a vital role in atherosclerosis (AS) progression, and vascular smooth muscle cells (VSMCs) are involved in the progression of AS. However, the in-depth mechanism by which circRNA regulates VSMC proliferation and migration remains to be elusive. Methods: We used tumor necrosis factor-alpha (TNF-α) to treat VSMCs to establish a cell model of AS. We used Cell Counting Kit-8, terminal-deoxynucleoitidyl transferase–mediated nick end labeling, and transwell assays to assess the proliferation, apoptosis, and migration in TNF-α-induced VSMCs. Moreover, the interaction between molecules was measured by RNA-binding protein immunoprecipitation, RNA pull-down, and luciferase reporter assays. Results: Our study found that a novel circRNA hsa_circ_0030042, which is derived from its host gene forkhead box O1 (FOXO1), was upregulated in TNF-α-induced VSMCs. Silencing of hsa_circ_0030042 inhibited proliferation and migration while promoting apoptosis in TNF-α-induced VSMCs. Mechanically, hsa_circ_0030042 positively regulated FOXO1 expression via sponging miR-514a-3p. Conclusions: Our study stated the vital role of the hsa_circ_0030042/miR-514a-3p/FOXO1 axis and provides a profound understanding about the circRNA in AS.
Variation in patient information and rehabilitation regimens after flexor tendon repair in the United Kingdom
Authors: Newington Lisa , Lane Jennifer CE , Holmes David GW , Gardiner Matthew D 
Published: April 2022

Introduction There is clinical uncertainty regarding the optimal method of rehabilitation following flexor tendon repair. Many splint designs and rehabilitation regimens are reported in the literature; however, there is insufficient evidence to support the use of any one regimen. The aim of this study was to describe rehabilitation guidelines used in the United Kingdom (UK) following zone I/II flexor tendon repair. Methods Using a cross-sectional design, hand units in the UK were invited to complete a short survey and to upload their flexor tendon rehabilitation guidelines and patient information material. Approval was granted by the British Association of Hand Therapists. Data were extracted in duplicate, using a pre-piloted form, and analysed using descriptive statistics. Results Thirty-five hand units responded (21%), providing 52 treatment guidelines. Three splinting regimens were described, and all involved early active mobilisation: (i) long dorsal-blocking splint (DBS); (ii) short DBS; and (iii) relative motion flexion splint. Duration of full-time splint wear ranged from 4 to 6 weeks. There were variations in splint design and composition of home exercise programmes, particularly for the long DBS. Where reported, recommended return to driving ranged from 8 to 12 weeks, and return to light work activities ranged from 5 to 10 weeks. Discussion Treatment guidelines varied across UK hand therapy departments, suggesting that patients receive differing advice about how to protect, move and use their hand after zone I/II flexor tendon repair. The disparity in splint wear duration, home exercise frequency and prescribed functional restrictions raises potential financial and social implications for patients. Future research should explore rehabilitation burden in addition to clinical outcomes.
The effectiveness of automated digital health solutions at successfully managing obesity and obesity-associated disorders: A PICO-structured investigation
Authors: Price James Christopher , Santos Heitor Oliveira , Bueno Allain Amador 
Published: April 2022

Most adults in the UK and USA are classified as overweight or obese. Recent studies suggest that the prevalence of obesity has further increased during the SARS-CoV-2 pandemic and associated lockdowns. Digital technologies may be effective at managing obesity and related comorbidities, a potential further justified by social isolation and distancing circumstances. This review of published literature employed a Patient-Intervention-Comparison-Outcome structured approach on the use of digital solutions to determine the effectiveness of their use in the management and treatment of obesity, hypertension, and type 2 diabetes and included commercially available, automated devices and applications that did not require intervention from a clinician. Our search covered studies published between January 2004 and February 2019, and 18 papers were included in the final analysis. The digital solutions reviewed were smartphone applications, wearable activity trackers, and ‘digital medicine offerings’ (DMO), including ingestible sensors and wearable patches. This study found that not all interventions were effective at encouraging the lifestyle changes required for the management of obesity. Smartphone applications requiring interaction from the patient appeared to be more effective at encouraging engagement with treatment interventions than more passive wearable activity trackers. Automated feedback from smartphone applications was effective at managing type 2 diabetes, while DMO were effective at reducing blood pressure. With the advancement of new technologies alongside a rapid increase in the prevalence of obesity and associated disorders, further studies comparing the various technologies available in larger sample populations for longer periods would help determine the most cost-effective preventive and therapeutic strategies.
Workspace and Accuracy Analysis on a Novel 6-UCU Bone-attached Parallel Manipulator
Authors: Dong Kaijie , Li Duanling , Xue Xingyu , Xu Chang , Wang Haowei , Gao Xianming 
Published: April 2022

AbstractWith the increasingly more extensive application of the medical surgical robot in the clinic, higher requirements have been put forward for medical robots. The bone-attached robot, a popular orthopedic robot in recent years, has a tendency of miniaturization and refinement. Thus, a bone-attached parallel manipulator (PM) based on 6-UCU (universal-cylindrical-universal) configuration is proposed, which is characterized by small volume, compact structure, high precision and six-dimensional force feedback. To optimize the structure and make it more compact, the workspace of the 6-UCU PM is analyzed based on the analysis of three kinds of constraint, and workspace model is established through spherical coordinate search method. This study also analyzes the influence of structural parameters on workspace, which may contribute to improving the efficiency of design and ensuring small-sized robots possess relatively large workspace. Moreover, to improve the motion accuracy, an error modeling method is developed based on the structure of 6-UCU PMs. According to this established error model, the output pose error curves are drawn using MATLAB software when the structure parameters change, and the influence of the structure and pose parameters change on the output pose error of PMs is analyzed. The proposed research provides the instruction to design and analysis of small PMs such as bone-attached robots.
Relationship and distribution of Salmonella enterica serovar I 4,[5],12:i:- strain sequences in the NCBI Pathogen Detection database
Authors: Trachsel Julian M. , Bearson Bradley L. , Brunelle Brian W. , Bearson Shawn M. D. 
Published: April 2022

Abstract
Background
Of the > 2600 Salmonella serovars, Salmonella enterica serovar I 4,[5],12:i:- (serovar I 4,[5],12:i:-) has emerged as one of the most common causes of human salmonellosis and the most frequent multidrug-resistant (MDR; resistance to ≥3 antimicrobial classes) nontyphoidal Salmonella serovar in the U.S. Serovar I 4,[5],12:i:- isolates have been described globally with resistance to ampicillin, streptomycin, sulfisoxazole, and tetracycline (R-type ASSuT) and an integrative and conjugative element with multi-metal tolerance named Salmonella Genomic Island 4 (SGI-4).

Results
We analyzed 13,612 serovar I 4,[5],12:i:- strain sequences available in the NCBI Pathogen Detection database to determine global distribution, animal sources, presence of SGI-4, occurrence of R-type ASSuT, frequency of antimicrobial resistance (AMR), and potential transmission clusters. Genome sequences for serovar I 4,[5],12:i:- strains represented 30 countries from 5 continents (North America, Europe, Asia, Oceania, and South America), but sequences from the United States (59%) and the United Kingdom (28%) were dominant. The metal tolerance island SGI-4 and the R-type ASSuT were present in 71 and 55% of serovar I 4,[5],12:i:- strain sequences, respectively. Sixty-five percent of strain sequences were MDR which correlates to serovar I 4,[5],12:i:- being the most frequent MDR serovar. The distribution of serovar I 4,[5],12:i:- strain sequences in the NCBI Pathogen Detection database suggests that swine-associated strain sequences were the most frequent food-animal source and were significantly more likely to contain the metal tolerance island SGI-4 and genes for MDR compared to all other animal-associated isolate sequences.

Conclusions
Our study illustrates how analysis of genomic sequences from the NCBI Pathogen Detection database can be utilized to identify the prevalence of genetic features such as antimicrobial resistance, metal tolerance, and virulence genes that may be responsible for the successful emergence of bacterial foodborne pathogens.
The evolution of microtubule associated proteins – a reference proteomic perspective
Authors: Gottschalk Amy C. , Hefti Marco M. 
Published: April 2022

AbstractMicrotubule associated proteins (MAPs), defined as proteins that bind microtubules but are not molecular motors or severing enzymes, play a key role in regulating microtubule stability in neurons. Existing studies of the evolutionary relationships between these proteins are limited to genomic data from a small number of species. We therefore used a large collection of publicly available reference-quality eukaryotic proteomes to carry out a phylogenetic analysis of microtubule associated proteins in both vertebrates and invertebrates. Complete or near-complete reference quality proteomes were obtained from Uniprot. Microtubule associated proteins were identified using InterProtScan, aligned using MUSCLE and then phylogenetic trees constructed using the WAG algorithm. We identified 889 proteins with tubulin binding domains, of which 663 were in eukaryotes, including 168 vertebrates and 64 invertebrates. The vertebrate proteins separated into three families, resembling human MAP 2, MAP4 and MAPT, respectively, while invertebrate MAPs clustered separately. We found significant variation in number of microtubule associated proteins and number of microtubule binding domains between taxa, with fish and mollusks having an unexpectedly high number of MAPs and binding domains, respectively. Our findings represent a novel analysis of the evolution of microtubule associated proteins based on publicly available proteomics data sets. We were able to confirm the phylogeny of MAPs identified based on more limited genomic analyses, and in addition, derived several novel insights on the structure and function of MAPs.