bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hormone-controlled cooperative binding of transcription factors drives synergistic induction of fasting-regulated genes
Authors: Goldberg Dana , Charni-Natan Meital , Buchshtab Nufar , Bar-Shimon Meirav , Goldstein Ido 
Published: May 2022

Abstract
During fasting, hepatocytes produce glucose in response to hormonal signals. Glucagon and glucocorticoids are principal fasting hormones that cooperate in regulating glucose production via gluconeogenesis. However, how these hormone signals are integrated and interpreted to a biological output is unknown. Here, we use genome-wide profiling of gene expression, enhancer dynamics and transcription factor (TF) binding in primary mouse hepatocytes to uncover the mode of cooperation between glucagon and glucocorticoids. We found that compared to a single treatment with each hormone, a dual treatment directs hepatocytes to a pro-gluconeogenic gene program by synergistically inducing gluconeogenic genes. The cooperative mechanism driving synergistic gene expression is based on ‘assisted loading’ whereby a glucagon-activated TF (cAMP responsive element binding protein; CREB) leads to enhancer activation which facilitates binding of the glucocorticoid receptor (GR) upon glucocorticoid stimulation. Glucagon does not only activate single enhancers but also activates enhancer clusters, thereby assisting the loading of GR also across enhancer units within the cluster. In summary, we show that cells integrate extracellular signals by an enhancer-specific mechanism: one hormone-activated TF activates enhancers, thereby assisting the loading of a TF stimulated by a second hormone, leading to synergistic gene induction and a tailored transcriptional response to fasting.
rna-tools.online: a Swiss army knife for RNA 3D structure modeling workflow
Authors: Magnus Marcin 
Published: May 2022

Abstract
Significant improvements have been made in the efficiency and accuracy of RNA 3D structure prediction methods in recent years; however, many tools developed in the field stay exclusive to only a few bioinformatic groups. To perform a complete RNA 3D structure modeling analysis as proposed by the RNA-Puzzles community, researchers must familiarize themselves with a quite complex set of tools. In order to facilitate the processing of RNA sequences and structures, we previously developed the rna-tools package. However, using rna-tools requires the installation of a mixture of libraries and tools, basic knowledge of the command line and the Python programming language. To provide an opportunity for the broader community of biologists to take advantage of the new developments in RNA structural biology, we developed rna-tools.online. The web server provides a user-friendly platform to perform many standard analyses required for the typical modeling workflow: 3D structure manipulation and editing, structure minimization, structure analysis, quality assessment, and comparison. rna-tools.online supports biologists to start benefiting from the maturing field of RNA 3D structural bioinformatics and can be used for educational purposes. The web server is available at https://rna-tools.online.
Dali server: structural unification of protein families
Authors: Holm Liisa 
Published: May 2022

Abstract
Protein structure is key to understanding biological function. Structure comparison deciphers deep phylogenies, providing insight into functional conservation and functional shifts during evolution. Until recently, structural coverage of the protein universe was limited by the cost and labour involved in experimental structure determination. Recent breakthroughs in deep learning revolutionized structural bioinformatics by providing accurate structural models of numerous protein families for which no structural information existed. The Dali server for 3D protein structure comparison is widely used by crystallographers to relate new structures to pre-existing ones. Here, we report two most recent upgrades to the web server: (i) the foldomes of key organisms in the AlphaFold Database (version 1) are searchable by Dali, (ii) structural alignments are annotated with protein families. Using these new features, we discovered a novel functionally diverse subgroup within the WRKY/GCM1 clan. This was accomplished by linking the structurally characterized SWI/SNF and NAM families as well as the structural models of the CG-1 family and uncharacterized proteins to the structure of Gti1/Pac2, a previously known member of the WRKY/GCM1 clan. The Dali server is available at http://ekhidna2.biocenter.helsinki.fi/dali. This website is free and open to all users and there is no login requirement.
Relationship between gamma-ray loudness and X-ray spectra of radio galaxies
Authors: Kayanoki Taishu , Fukazawa Yasushi 
Published: May 2022

Abstract
The Fermi satellite has detected ∼ 60 radio galaxies (RGs). In this study, we investigate the difference in the properties of X-ray spectra between GeV-loud RGs and GeV-quiet RGs. Our sample comprises 68 objects: 36 RGs detected with Fermi and 32 RGs not detected with gamma-rays. We analyzed the X-ray spectra of these 68 objects using data from the XMM-Newton, Chandra, NuSTAR, and Swift satellites. Our results show that most GeV-loud RGs do not exhibit significant absorption, while $\sim \!50\%$ of the GeV-quiet RGs exhibit significant absorption. This suggests that the jet of GeV-loud RGs is viewed from a small angle, and thus the emission is not easily blocked by the torus. Moreover, we reported that RGs with a heavy absorption are mostly in the X-ray luminosity range of 1043–1045 erg s−1; however, few RGs with lower and higher luminosity suffer from heavy absorption. This is the same trend as that of Seyfert galaxies.
Years of life lost associated with COVID-19 deaths in the USA during the first 2 years of the pandemic
Authors: Quast Troy , Andel Ross , Gregory Sean , Storch Eric A 
Published: May 2022

Abstract

Background
Prior estimates of the years of life lost (YLLs) in the USA associated with coronavirus disease 2019 (COVID-19) were 1.2 million through 11 July 2020 and 3.9 million through 31 January 2021 (which roughly coincides with the first full year of the pandemic). The aim of this study is to update YLL estimates through the first 2 years of the pandemic.

Methods
We employed data regarding COVID-19 deaths through 5 February 2022 by jurisdiction, gender and age group. We used actuarial life expectancy tables by gender and age to estimate YLLs.

Results
We estimated roughly 9.7 million YLLs due to COVID-19 deaths. The number of YLLs per 10 000 capita was 297.5, with the highest rate in Mississippi (482.7) and the lowest in Vermont (61.4). There was substantial interstate variation in the timing of YLLs and differences in YLLs by gender. YLLs per death increased from 9.2 in the first year of the pandemic to 10.8 through the first 2 years.

Conclusions
Our findings improve our understanding of how the mortality effects of COVID-19 have evolved. This insight can be valuable to public health officials as the disease moves to an endemic phase.
An Innovative Approach to a Multitrack Advance Practice Registered Nurse Program: The Integration of Psychiatric Mental Health and Primary Care Cohorts
Authors: Durham Catherine O. , Lauerer Joy , Smith Whitney 
Published: May 2022

Abstract
We describe how an online graduate nurse practitioner program combined psychiatric mental health nurse practitioner and primary care advanced practice registered nurse (AGNP/FNP/PNP) tracks into an integrated curriculum. Student evaluations and assessments, along with board certification scores, demonstrated improvement in identifying and managing behavioral health problems, as well as increased competence and collaboration with other nurse practitioner students. Details of the integrated curriculum are provided.
Interprofessional Collaboration Among Dental Hygiene and Nursing Students on the Oral Health of Cancer Patients
Authors: Warren Debin , Stanek Joan , Dsouza Roxanne Mariola , Ciarrocca Katharine , Brame Jennifer L. 
Published: May 2022

Abstract
One third of patients diagnosed with cancer develop oral complications during cancer treatment. Health care professionals play an important role in the management of patients undergoing cancer therapies; however, optimal oral care for cancer patients is often missing from nursing and dental hygiene curricula. A quasi-experimental mixed-methods study was conducted with accelerated bachelor of nursing and dental hygiene students following a presentation and small-group case review. Pre/post surveys and findings from a debriefing session showed increased confidence to screen, counsel, and refer patients between disciplines compared to a control group.
Building Academic Leadership Capacity Through Coaching
Authors: Patterson Barbara J. , Brewington Janice , Krouse Anne , Hall Meg 
Published: May 2022

Abstract

AIM
The purpose of this study was to examine the influence of coaching in a 12-month leadership development program for nurse faculty and administrators who transition to leadership positions or who aspire to lead.

BACKGROUND
There is a critical need in nursing education to build leadership capacity. One strategy to foster leadership development is through coaching. Although developmental leadership programs for nurse educators exist, limited empirical data exist in nursing academia examining the effectiveness of coaching on leadership.

METHOD
The design was qualitative descriptive. Using a semistructured interview guide, participants (N = 12) responded to open-ended questions about their coaching experience.

RESULTS
Data analysis revealed three themes: encouraging intentional reflection of self and leadership, validating perceptions of challenging professional situations, and strategizing options for action plans and behaviors.

COAHCING
Coaching holds a great deal of promise as a means to develop the next generation of academic nurse leaders.
Developing an Interprofessional e-Consult Checklist for Family Nurse Practitioner Students
Authors: Conelius Jaclyn 
Published: May 2022

Abstract
Family nurse practitioners (FNPs) are filling the provider gaps in primary care. Primary care patients require referrals to different types of specialty providers that are not always readily available. The use of electronic consultations (e-consults) can fill this gap. FNPS may not be aware of e-consults or may feel they are not beneficial in their practice, likely because of a lack of training. This article details the development of an e-consult checklist for graduate FNPs.
Underrepresented Ethnic Minority Nursing Students’ Perceptions of Factors That Enhanced or Hindered Their Self-Efficacy
Authors: Page Julianne 
Published: May 2022

Abstract
Self-efficacy is the perceived confidence of students in their ability to learn new skills and knowledge. This study examined underrepresented ethnic minority students’ perceptions of the factors that enhanced/hindered their self-efficacy in a bachelor of science in nursing program. Qualitative analysis revealed three themes: 1) doing it, 2) connecting with clinical faculty, and 3) dealing with multiple stressors. Students described clinical faculty’s teaching strategies that enhanced their nursing self-efficacy as they managed multiple stressors in their lives.
Association of Respiratory Parameters at Venovenous Extracorporeal Membrane Oxygenation Liberation With Duration of Mechanical Ventilation and ICU Length of Stay: A Prospective Cohort Study
Authors: Thiara Sonny , Serpa Neto Ary , Burrell Aidan J. C. , Fulcher Bentley J , Hodgson Carol L. ,   for the EXCEL Study Investigators, the ANZICS-CTG and the International ECMO Network.
Published: May 2022

OBJECTIVES:
Although the criteria for initiation of venovenous extracorporeal membrane oxygenation (VV ECMO) are well defined, the criteria and timing for VV ECMO decannulation are less certain. The aim of this study was to describe the ventilation and physiologic factors at the time of VV ECMO decannulation and to determine if these factors have association with mechanical ventilation or ICU length of stay after ECMO decannulation.

DESIGN:
Multicenter, prospective cohort study.

SETTING:
Eleven ICUs in Australia.

PATIENTS:
Adult patients treated with VV ECMO from March 19, 2019, to September 20, 2020.

INTERVENTIONS:
Liberation from VV ECMO.

RESULTS:
Of 87 patients receiving VV ECMO, the median age was 49 years (interquartile range, 37–59 yr), 61 of 87 (70%) were male, and 52/87 (60%) had a diagnosis of acute respiratory distress syndrome. There were 24 of 87 patients (28%) who died prior to day 90. No patient required a second run of VV ECMO. In a multivariate models, a higher partial pressure of arterial carbon dioxide (p < 0.01) and respiratory rate at the time of decannulation (p = 0.01) were predictive of a longer duration of mechanical ventilation and ICU length of stay postdecannulation in survivors. Higher positive end-expiratory pressure at ECMO decannulation was associated with shorter duration of ICU length of stay post-ECMO decannulation in survivors (p = 0.01).

CONCLUSIONS:
A higher partial pressure of arterial carbon dioxide and higher respiratory rate at ECMO decannulation were associated with increased duration of mechanical ventilation and increased duration of ICU stay postdecannulation, and increased positive end-expiratory pressure at decannulation was associated with decreased duration of ICU stay postdecannulation. Future research should further investigate these associations to establish the optimal ventilator settings and timing of liberation from VV ECMO.
Creating a Rural Plastic Surgery Practice: Social and Financial Impacts
Authors: Meyerson Joseph , Shields Tyler , Liechty Andrew , O’Brien Andrew 
Published: May 2022

Summary:
In the United States, 25 million people are without reasonable access to a plastic surgeon. Previous studies have demonstrated that rural populations have limitations to healthcare, and these limitations result in poor quality of life and poor outcomes. New research points to the importance of rural plastic surgery, but still lacks clarity of what the creation and development of a rural plastic surgery practice may entail. Our aim with this study was to discover both the surgical compilation and financial impact of a single rural plastic surgeon’s practice. We reviewed the first 1.5 years of a single surgeon’s plastic surgery practice from its beginnings in a rural community at a critical access hospital with no previous plastic surgery presence. During the study period, the surgeon completed 2062 clinic visits and 305 surgeries. The practice involved approximately 70% hand surgery and the remaining general plastic surgery. The practice generated approximately $8 million in charges and $3.5 million in collections. Collections were broken down by $2.6 million in surgical procedures, $560,000 from clinical practice, and $330,000 from downstream revenue. A rural plastic surgeon’s practice may have noted positive impacts on medical care and financial bottom lines in rural communities.
Fostering organizational resilience: The relevance of organization theory in a postpandemic world
Authors: Zinn Jacqueline 
Published: May 2022

Associate Editor’s Note
This article is an adapted version of Dr. Jacqueline Zinn's Keith G. Provan Distinguished Scholar Award plenary to the Health Care Management Division of the Academy of Management in 2020. We are excited to share it with you because it is noteworthy among scholarly career award plenaries. Specifically, the article does two big things exceptionally well: (a) provides a compelling and informative retrospective on a truly exceptional scholarly career renowned for work that consistently and deeply engages with practice, practitioners, and emerging, urgent problems in a conceptually and empirically rigorous manner and (b) inventively connects her research to the health care, managerial, and organizational challenges posed by the pandemic (and pandemics from prior eras) to provide a forward looking research agenda on organizational resilience and well-being that offers ready-made conceptual development and empirical work for the next generation.
Exploring system features of primary care practices that promote better providers’ clinical work satisfaction: A qualitative comparative analysis
Authors: Liu Lingrui , Chien Alyna T. , Singer Sara J. 
Published: May 2022

Background
Health care delivery system features can have a profound effect on how frontline physicians and other clinical personnel in primary care practices (primary care providers [PCPs]) view the quality and safety of what they deliver and, ultimately, their clinical work satisfaction.

Purpose
The aim of this study was to investigate the combinations of system features (i.e., team dynamics, provider-perceived safety culture, and patient care coordination between PCPs) that are most conducive to positively enhancing PCPs’ clinical work satisfaction.

Approach
Nineteen Harvard-affiliated primary care practice sites participated in the Academic Innovations Collaborative 2012–2016, which aimed to establish team-based care and improve patient safety. An All-Staff Survey was administered to 854 PCPs in 2015. The survey measured provider experience of team dynamics, provider-perceived safety culture, patient care coordination between PCPs, and providers’ clinical work satisfaction. We performed a qualitative comparative analysis to identify “recipes,” that is, combinations of conditions necessary and sufficient for enhancing PCPs’ clinical work satisfaction.

Results
Strong provider-perceived safety culture and effective team dynamics constitute sufficient conditions that, when present in practices, could best support PCPs to achieve greater clinical work satisfaction.

Conclusions
Our findings suggest the importance of creating and sustaining a strong safety culture and of establishing and implementing highly functioning teams in primary care practices for enhancing PCPs’ clinical work satisfaction.

Practice Implications
Conducting the qualitative comparative analysis provides a new perspective for informing primary care and encouraging primary care practices to pursue strategic priorities for enhancing PCPs’ clinical work satisfaction and providing safe, high-quality care.
The Effectiveness of Hydrotherapy-Halliwick Concept in Children With Juvenile Idiopathic Arthritis: Assessment and Treatment
Authors: Karastamati Christina , Chandolias Konstantinos , Grammatikou Georgios , Hristara-Papadopoulou Alexandra 
Published: May 2022

Introduction:
The main symptoms of juvenile idiopathic arthritis (JIA) include swelling of the affected joints, sensitivity, painful movement restriction, and walking disorders. A wealth of findings and research is available on the benefits of various physiotherapy interventions. Instead, there are a small number of studies that examine the benefits of more alternative forms of physiotherapy such as hydrotherapy and more specifically the Halliwick therapy. In the hydrotherapy studies so far, the results are equivalent to classical physiotherapy and sometimes better.

Aim:
This study attempts to record and highlight the effect of the Halliwick hydrotherapy in children with JIA in a 2-month intervention program. In particular, it focuses on (1) balance and (2) plantar pressure distribution before and after the intervention.

Methodology:
The methodology we used to collect our data was quantitative research, and the research tools used were the Berg balance scale and a modular platform system to measure plantar pressure. The sample consisted of 16 children with JIA who took measurements before and after the intervention. The duration of this intervention was 2 months. Data analysis was performed using the SPSS v21 statistical program.

Results:
Some remarkable results were obtained: (1) all subjects had no significant change in the already good balance; and (2) all subjects had a significant improvement in the uniform distribution of plantar pressure following the Halliwick treatment sessions.

Conclusions:
The philosophy of the Halliwick hydrotherapy is a more alternative form of physical therapy that has been shown to contribute to improving the distribution of weight and plantar pressure in children suffering from JIA.
Effect of different doses of atorvastatin on collateral formation in coronary artery disease patients with coronary atherosclerosis
Authors: Liu Ling , Gao Lei , Tan Huilian , Qi Yanchao , Cui Dong , Wang Zhen , Liu Jun 
Published: May 2022

Objective
The study aimed to explore the effect of different doses of atorvastatin on collateral formation in coronary artery disease (CAD) patients with coronary atherosclerosis.

Methods
The study included 218 CAD patients who received treatment between January 2017 and January 2020 at our hospital. They were assigned to the high-dose group (40 mg atorvastatin) and the low-dose group (20 mg atorvastatin) using the random table method with 109 patients per group. The blood lipid levels, TNF-α, hs-CRP, NO, and coronary atherosclerosis collateral formation before and after treatment in the two groups were compared, and favorable factors of good coronary artery collateral circulation were analyzed by multivariate logistic regression analysis.

Results
LDL-C, TG, and TC levels decreased, whereas HDL-C levels increased in the two groups after treatment. The high-dose group had lower LDL-C, TG, and TC levels but higher HDL-C levels than the low-dose group, and the difference was statistically significant (P < 0.05). TNF-α and hs-CRP levels decreased while NO levels increased in both groups after treatment. The high-dose group had lower TNF-α and hs-CRP levels but higher NO levels than the low-dose group, and the difference was statistically significant (P < 0.05).

Conclusion
High-dose atorvastatin could blood lipid levels of modulate CAD patients and promote coronary atherosclerosis collateral formation. In addition, hypertension, LDL-C, HDL-C, TNF-α, hs-CRP, and NO were independent determinants of good coronary artery collateral circulation.
Impact of Dermal Matrix Brand in Implant-Based Breast Reconstruction Outcomes
Authors: Johnson Ariel C. , Colakoglu Salih , Siddikoglu Duygu , Li Angel , Kaoutzanis Christodoulos , Cohen Justin B. , Chong Tae W. , Mathes David W. 
Published: May 2022

Background:
Implant-based reconstruction is the most common procedure for breast reconstruction after mastectomy. Acellular dermal matrix is used to provide additional coverage in subpectoral and prepectoral implant placement. In this study, the authors compared postoperative outcomes between AlloDerm (LifeCell, Branchburg, N.J.) and DermACELL (Stryker, Kalamazoo, Mich.), two acellular dermal matrix brands.

Methods:
A retrospective review of implant-based breast reconstruction from 2016 to 2020 was conducted. Patient demographics and comorbidities, implant size and location, acellular dermal matrix choice, and postoperative outcomes were recorded. Primary outcomes assessed were seroma and infection compared between two acellular dermal matrix brands. Independent clinical parameters were assessed with multiple logistic regression models for the primary outcomes.

Results:
Reconstruction was performed in 150 patients (241 breasts). Eighty-eight patients underwent expander placement with AlloDerm and 62 patients with DermACELL. There were no significant differences in patient characteristics between the two groups. There was a significantly higher incidence of seroma in the AlloDerm group in univariate (AlloDerm 21.7 percent versus DermACELL 8.2 percent, p < 0.005) and multivariate analyses (p = 0.04; 95 percent CI, 1.02 to 6.07). Acellular dermal matrix use (regardless of type) was not associated with higher rates of infection (p = 0.99), but body mass index was (p = 0.004).

Conclusions:
Both AlloDerm and DermACELL had similar infection rates regardless of contributing risk factors. AlloDerm was found to be a risk factor for seroma formation in the postoperative period. As such, it is important to be aware of this complication when performing implant-based reconstruction with this brand of acellular dermal matrix.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.