bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents (the TECTO trial): a statistical analysis plan for the randomised clinical trial
Authors: Olsen Markus Harboe , Hagstrøm Julie , Lønfeldt Nicole Nadine , Uhre Camilla , Uhre Valdemar , Pretzmann Linea , Christensen Sofie Heidenheim , Thoustrup Christine , Korsbjerg Nicoline Løcke Jepsen , Mora-Jensen Anna-Rosa Cecilie , Ritter Melanie , Engstrøm Janus , Lindschou Jane , Siebner Hartwig Roman , Verhulst Frank , Jeppesen Pia , Jepsen Jens Richardt Møllegaard , Vangkilde Signe , Thomsen Per Hove , Hybel Katja , Clemmesen Line Katrine Harder , Gluud Christian , Plessen Kerstin Jessica , Pagsberg Anne Katrine , Jakobsen Janus Christian 
Published: October 2022

Abstract
Background
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder which affects up to 3% of children and adolescents. OCD in children and adolescents is generally treated with cognitive behavioural therapy (CBT), which, in more severely affected patients, can be combined with antidepressant medication. The TECTO trial aims to compare the benefits and harms of family-based CBT (FCBT) versus family-based psychoeducation/relaxation training (FPRT) in children and adolescents aged 8 to 17 years. This statistical analysis plan outlines the planned statistical analyses for the TECTO trial.

Methods
The TECTO trial is an investigator-initiated, independently funded, single-centre, parallel-group, superiority randomised clinical trial. Both groups undergo 14 sessions of 75 min each during a period of 16 weeks with either FCBT or FPRT depending on the allocation. Participants are randomised stratified by age and baseline Children’s Yale–Brown Obsessive-Compulsive Scale (CY-BOCS) score. The primary outcome is the CY-BOCS score. Secondary outcomes are health-related quality of life assessed using KIDSCREEN-10 and adverse events assessed by the Negative Effects Questionnaire (NEQ). Primary and secondary outcomes are assessed at the end of the intervention. Continuous outcomes will be analysed using linear regression adjusted for the stratification variables and baseline value of the continuous outcome. Dichotomous outcomes will be analysed using logistic regression adjusted for the stratification variables. The statistical analyses will be carried out by two independent blinded statisticians.

Discussion
This statistical analysis plan includes a detailed predefined description of how data will be analysed and presented in the main publication before unblinding of study data. Statistical analysis plans limit selective reporting bias. This statistical analysis plan will increase the validity of the final trial results.

Trial registration
ClinicalTrials.gov NCT03595098. July 23, 2018
Periviscerokinin (Cap2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output
Authors: Wulff Juan P. , Temeyer Kevin B. , Tidwell Jason P. , Schlechte Kristie G. , Lohmeyer Kimberly H. , Pietrantonio Patricia V. 
Published: October 2022

Abstract
Background
The cattle fever tick, Rhipicephalus (Boophilus) microplus, is a vector of pathogens causative of babesiosis and anaplasmosis, both highly lethal bovine diseases that affect cattle worldwide. In Ecdysozoa, neuropeptides and their G-protein-coupled receptors play a critical integrative role in the regulation of all physiological processes. However, the physiological activity of many neuropeptides is still unknown in ticks. Periviscerokinins (CAP2b/PVKs) are neuropeptides associated with myotropic and diuretic activities in insects. These peptides have been identified only in a few tick species, such as Ixodes ricinus, Ixodes scapularis and R. microplus, and their cognate receptor only characterized for the last two.

Methods
Expression of the periviscerokinin receptor (Rhimi-CAP2bR) was investigated throughout the developmental stages of R. microplus and silenced by RNA interference (RNAi) in the females. In a first experiment, three double-stranded (ds) RNAs, named ds680-805, ds956-1109 and ds1102-1200, respectively, were tested in vivo. All three caused phenotypic effects, but only the last one was chosen for subsequent experiments. Resulting RNAi phenotypic variables were compared to those of negative controls, both non-injected and dsRNA beta-lactamase-injected ticks, and to positive controls injected with beta-actin dsRNA. Rhimi-CAP2bR silencing was verified by quantitative reverse-transcriptase PCR in whole females and dissected tissues.

Results
Rhimi-CAP2bR transcript expression was detected throughout all developmental stages. Rhimi-CAP2bR silencing was associated with increased female mortality, decreased weight of surviving females and of egg masses, a delayed egg incubation period and decreased egg hatching (P < 0.05).

Conclusions
CAP2b/PVKs appear to be associated with the regulation of female feeding, reproduction and survival. Since the Rhimi-CAP2bR loss of function was detrimental to females, the discovery of antagonistic molecules of the CAP2b/PVK signaling system should cause similar effects. Our results point to this signaling system as a promising target for tick control.

Graphical Abstract
Short-term effects of tropical cyclones on the incidence of dengue: a time-series study in Guangzhou, China
Authors: Li Chuanxi , Zhao Zhe , Yan Yu , Liu Qiyong , Zhao Qi , Ma Wei 
Published: October 2022

Abstract
Background
Limited evidence is available about the association between tropical cyclones and dengue incidence. This study aimed to examine the effects of tropical cyclones on the incidence of dengue and to explore the vulnerable populations in Guangzhou, China.

Methods
Weekly dengue case data, tropical cyclone and meteorological data during the tropical cyclones season (June to October) from 2015 to 2019 were collected for the study. A quasi-Poisson generalized linear model combined with a distributed lag non-linear model was conducted to quantify the association between tropical cyclones and dengue, controlling for meteorological factors, seasonality, and long-term trend. Proportion of dengue cases attributable to tropical cyclone exposure was calculated. The effect difference by sex and age groups was calculated to identify vulnerable populations. The tropical cyclones were classified into two levels to compare the effects of different grades of tropical cyclones on the dengue incidence.

Results
Tropical cyclones were associated with an increased number of dengue cases with the maximum risk ratio of 1.41 (95% confidence interval 1.17–1.69) in lag 0 week and cumulative risk ratio of 2.13 (95% confidence interval 1.28–3.56) in lag 0–4 weeks. The attributable fraction was 6.31% (95% empirical confidence interval 1.96–10.16%). Men and the elderly were more vulnerable to the effects of tropical cyclones than the others. The effects of typhoons were stronger than those of tropical storms among various subpopulations.

Conclusions
Our findings indicate that tropical cyclones may increase the incidence of dengue within a 4-week lag in Guangzhou, China, and the effects were more pronounced in men and the elderly. Precautionary measures should be taken with a focus on the identified vulnerable populations to control the transmission of dengue associated with tropical cyclones.

Graphical Abstract
Methanol poisoning outbreak in Saudi Arabia: a case series
Authors: Eskandrani Rawan , Almulhim Khalid , Altamimi Abdulla , Alhaj Abeer , Alnasser Shahd , Alawi Laale , Aldweikh Eman , Alaufi Khalid , Mzahim Bandr 
Published: October 2022

Abstract
Background
Outbreaks of methanol poisoning have been described in the medical literature in different regions around the world. Even though in Saudi Arabia a few outbreaks of methanol poisoning have occurred, they remain undocumented. Herein, we describe several cases of methanol poisoning in Saudi Arabia with the goal of increasing awareness about the dangers of methanol poisoning among healthcare staff.

Case presentation
Nine middle-aged Saudi patients (five men aged 24, 26, 27, 36, and 49 years and four females aged 19, 20, 24, and 25 years) were admitted to our emergency department after alcohol consumption. All patients presented with severe metabolic acidosis and some visual impairment. Treatment was initiated based on the clinical suspicion of methanol intoxication because of laboratory test limitations and time constraints. Patients showed improvement and favorable hospital outcomes after aggressive empirical treatment.

Conclusions
Many social and cultural factors influence the lack of reporting of methanol poisoning cases in Saudi Arabia. We believe it is important to document these outbreaks to increase the knowledge among healthcare providers and promote public health awareness. A high index of suspicion and the development of local public health networks to monitor, survey, follow-up, and facilitate data exchange can help healthcare providers recognize and aggressively treat affected individuals. Early empiric and aggressive management can greatly decrease morbidity and mortality despite challenges and limited resources.
Intravascular ultrasound-based decision tree model for the optimal endovascular treatment strategy selection of femoropopliteal artery disease—results from the ONION Study-
Authors: Yazu Yuko , Fujihara Masahiko , Takahara Mitsuyoshi , Kurata Naoya , Nakata Aya , Yoshimura Hitoshi , Ito Tomoaki , Fukunaga Masashi , Kozuki Amane , Tomoi Yusuke 
Published: October 2022

Abstract
Background
The role of catheter-based imaging in peripheral interventions for lower extremity artery disease (LEAD) has increased with percutaneous interventions. To clarify the relation between intravascular ultrasound (IVUS) information and procedure selection strategy for endovascular treatment therapy (EVT) of the femoropopliteal artery in the real-world clinical settings wherein new endovascular technologies (NETs), including drug-coated balloon (DCB), drug-eluting stent (DES), and covered stent-graft (CS). Our retrospective multicenter analysis examined symptomatic 970 patients treated by EVT for de novo femoropopliteal lesions with IVUS guidance. The decision tree analysis was performed retrospectively to determine the association of IVUS and angiography parameters with the strategy selection of endovascular procedures. We divided the study population according to the developed tree, and identified the most popular strategy selection in each subgroup. We finally examined whether the restenosis risk would be different among respective subgroups of the tree.

Results
During the study periods, plain old balloon angioplasty, DCB, and bare nitinol stent were most frequently selected (25.3%, 23.9%, and 23.8%, respectively). The drug-eluting stent (DES), covered stent (CS), and spot stent strategies were used in 7.3%, 11.5%, and 8.1%. NETs had the lowest restenosis risk in the overall population. The decision tree had a depth of six branches and divided the patients into 11 subgroups by IVUS and angiography parameters. The restenosis rate was similarly low among these 11 subgroups when the most popular NET in each subgroup was selected (P = 0.94).

Conclusions
The use of IVUS data along with angiography data would standardize the selection of endovascular procedures and can improve patency outcomes if NETs are used properly.
Study on molecular expression of long non-coding RNA Glypican3 in hepatocellular cancer patients
Authors: Ramadan Ahmed , Abdelaziz Ashraf Omar , Sabry Dina , Fathi Shaimaa Abd El tawab , Nabeel Mohamed Mahmoud , Shousha Hend Ibrahim , Elbaz Tamer Mahmoud , Lithy Rania mohamed , Ryed Hoda Ramadan 
Published: October 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the main cancers in the world with a high mortality rate. The molecular mechanisms of HCC are poorly understood. Long non-coding RNAs (lncRNAs) have a role in HCC pathogenesis. Glypican3 (GPC3) is a cell surface oncofetal proteoglycan that is expressed in HCC, and its overexpression predicts a poorer prognosis. We aimed to assess the levels of alfa fetoprotein (AFP), lncRNA AF085935 gene expression, and GPC3 protein in HCC patients.

Patients and methods
The patients were classified into three groups: HCC group, cirrhotic group, and healthy control group. For all groups, we performed clinical examinations, laboratory investigations, and imaging. The levels of AFP, GPC3 protein, and LncRNA gene expression were estimated. A statistical analysis was done.

Results
Levels of GPC3 and LncRNA gene expression were significantly higher in the HCC group versus other groups. LncRNA gene and GPC3 levels are excellent for the detection of HCC with a sensitivity of 96% and 87%, respectively. Specificity was 81% and 64%, respectively. Linear regression analysis showed that LncRNA gene expression and GPC3 protein are significant predictors for HCC (p = 0 and p = 0.001, respectively). Log rank analysis based on GPC3 and LncRNA gene expression levels in HCC patients showed that high expression of GPC3 and LncRNA is associated with shorter overall survival than those with low expressions (p value < 0.001).

Conclusion
In our study, LncRNA gene expression and GPC3 levels are good diagnostic and prognostic biomarkers for HCC patients.
Outcomes With Local Therapy and Tyrosine Kinase Inhibition in Patients With ALK/ROS1/RET-Rearranged Lung Cancers
Authors: Hubbeling Harper , Choudhury Noura , Flynn Jessica , Zhang Zhigang , Falcon Christina , Rusch Valerie W. , Park Bernard J. , Ziv Etay , Shaverdian Narek , Gelblum Daphna Y. , Shepherd Annemarie F. , Simone Charles B. , Wu Abraham J. , Gomez Daniel R. , Drilon Alexander , Rimner Andreas 
Published: October 2022

PURPOSE Local therapy prolongs progression-free survival in patients with oligometastatic non–small-cell lung cancers treated with chemotherapy. We previously reported that local therapy also prolongs survival and time to next therapy in patients on tyrosine kinase inhibitors (TKIs) for EGFR-mutant lung adenocarcinomas. Here, we investigate the role of local therapy in patients progressing on TKIs for ALK/ ROS1/ RET-rearranged lung adenocarcinomas. MATERIALS AND METHODS Patients with advanced ALK/ ROS/ RET-rearranged lung adenocarcinomas who underwent radiation, surgery, or percutaneous thermal ablation from 2012 to 2020 for progression on an ALK/ROS1/RET TKI were included. Progression patterns were identified. Times from local therapy to progression, next therapy, and death were measured. RESULTS Sixty-one patients with ALK (n = 37), ROS1 (n = 12), and RET (n = 12) fusions were identified. Patients received radiotherapy (92%), surgery (13%), and percutaneous thermal ablation (8%). Local therapy was administered for solitary/oligoprogressive (94%) or polyprogressive (6%) disease. For most patients (85%), local therapy addressed all progressing sites. The median times from any local therapy to subsequent progression and next systemic therapy were 6.8 months (95% CI, 5.1 to 8.1) and 10 months (95% CI, 8.4 to 15.3), respectively. Third or greater local therapy was associated with shorter time to progression and next therapy than first/second local therapies (hazard ratio, 4.97; P < .001 and hazard ratio, 2.48; P < .001). The median overall survival from first local therapy was 34 months (95% CI, 26 to not reached). CONCLUSION Local therapy for progression on ALK, ROS1, or RET TKIs is associated with clinically meaningful time on continued TKI therapy beyond progression, especially earlier in the course of disease.
Pd-Mediated Light-Controlled Living Radical Polymerization of Methyl Acrylate
Authors: Sumino Shuhei , Ryu Ilhyong 
Published: October 2022

Abstract
The radical polymerization of methyl acrylate in the presence of a palladium dimer complex and ethyl iodoacetate as an initiator under photoirradiation conditions led to the formation of poly(methyl acrylate) having good Ð values. The polymerization could be controlled by switching the light on and off, exhibiting living characteristics. We propose that such α-Pd polyesters could function as dormant species, which would allow a pair of transient α-keto radicals and persistent Pd radicals to be generated upon photoirradiation.
Η Αξιολόγηση του Μαθητή από τη Σκοπιά των Εκπαιδευτικών
Authors: Ρέλλος Νικόλαος 
Published: October 2022

«Η αξιολόγηση είναι μια από τις βασικές αποστολές του εκπαιδευτικού κατά την άσκηση των διδακτικών του καθηκόντων». Κατά την αντιπαράθεση με το θέμα της αξιολόγησης του μαθητή ανακύπτει κατ’ αρχήν το ερώτημα, κατά πόσον ο εκπαιδευτικός είναι ή αισθάνεται ικανός (δηλαδή επαρκώς κατηρτισμένος), για να μπορέσει να ανταποκριθεί επιτυχώς στην εκπλήρωση της ανωτέρω αποστολής. Επιτυχής ανταπόκριση σημαίνει εδώ να εκφέρει ο εκπαιδευτικός αξιολογική κρίση, η οποία κινούμενη εντός του πνεύματος της παιδαγωγικής λειτουργίας της αξιολόγησης, υπηρετεί την ατομική ενίσχυση του παιδιού, προσφέροντας σ’ αυτό ενθάρρυνση και σημεία στήριξης για την παραπέρα μαθησιακή (και κοινωνικοποιητική) του πορεία. Δύο μεγάλοι άξονες ερωτήσεων της έρευνας έχουν ως πυρήνα, αντίστοιχα, τη βαθμολογική και περιγραφική αξιολόγηση. Μέσα από πολλές υποερωτήσεις εδώ γίνεται σε τελική ανάλυση κριτική θεώρηση της βαθμολογικής και περιγραφικής αξιολόγησης και παρουσιάζονται -καλυμμένα- τα πλεονεκτήματα και μειονεκτήματα της μιας και της άλλης.
Αξιολόγηση, Σχεδιασμός και Προετοιμασία Επιμορφωτικού Προγράμματος Εκπαιδευτικών Δευτεροβάθμιας Εκπαίδευσης σε παιδιά Ρομά
Authors: Ντρενογιάννη Ελένη , Λιάμπας Αναστάσιος 
Published: October 2022

Η εργασία παρουσιάζει την αξιολόγηση, το σχεδιασμό, την προετοιμασία και τα κύρια συμπεράσματα της υλοποίησης ενός επιμορφωτικού προγράμματος από απόσταση για εκπαιδευτικούς δευτεροβάθμιας εκπαίδευσης που είχαν στις τάξεις τους παιδιά από κοινωνικά ευάλωτες ομάδες. Σκοπός του επιμορφωτικού προγράμματος ήταν η ενδυνάμωση των εκπαιδευτικών, ώστε να αναλάβουν πρωτεύοντα και ενεργητικό ρόλο στην εκπαιδευτική πράξη. Οι εκπαιδευτικοί μπόρεσαν και την προσέγγισαν ερευνητικά, μελέτησαν τις μεθόδους και τις διδακτικές τους πρακτικές και την αναπροσανατόλισαν σε Έρευνα δράση. Γνώρισαν και κατανόησαν τους μαθητές τους, έθεσαν στο επίκεντρο την επίτευξη στόχων που οι ίδιοι επέλεξαν και ήταν καίριας σημασίας για την τάξη τους με εξαιρετικά αποτελέσματα τόσο για τους ίδιους όσο και για τους μαθητές τους.
Κύπρου Χρυσάνθη, «“Οι εξομολογήσεις ενός νόθου κοριτσιού”: μια ανάγνωση»
Authors: Χριστοδουλίδου Λουίζα 
Published: October 2022

Σε αυτή την εργασία θα μας απασχολήσει το διήγημα «Οι εξομολογήσεις ενός νόθου κοριτσιού» (Πεζός Λόγος ΙΙΙ, Ιστορίες από την Κύπρο την αγέρινη, 1973) του Κύπρου Χρυσάνθη. Οι άξονες της αναγνωστικής μας πρόσληψης εστιάζονται στην εξιστόρηση των γεγονότων από την οπτική γωνία του αυτοδιηγητικού αφηγητή - της κεντρικής ηρωίδας. Η αναπαράσταση του τόπου και των συμβολικών του διαστάσεων είναι μία άλλη ενδιαφέρουσα πτυχή την οποίαν θα αναδείξουμε με τη συμβολή της φαινομενολογίας του τόπου, εφόσον ο τόπος και το τοπίο, κυρίως το σπίτι, κεντρικοί άξονες της κειμενικής οργάνωσης του διηγήματος, δημιουργούν το σκηνικό μέσα στο οποίο εκδηλώνονται τα πάθη των δρώντων προσώπων. Ο χώρος γίνεται το πρόσχημα για τις μεταβολές που συμβαίνουν στην ψυχή της ηρωίδας και συμβάλλουν στην ανάδειξη του εσωτερικού της κόσμου.
A geospatial source selector for federated GeoSPARQL querying
Authors: Troumpoukis Antonis , Konstantopoulos Stasinos , Prokopaki-Kostopoulou Nefeli 
Published: October 2022

Background: Geospatial linked data brings into the scope of the Semantic Web and its technologies, a wealth of datasets that combine semantically-rich descriptions of resources with their geo-location. There are, however, various Semantic Web technologies where technical work is needed in order to achieve the full integration of geospatial data, and federated query processing is one of these technologies. Methods: In this paper, we explore the idea of annotating data sources with a bounding polygon that summarizes the spatial extent of the resources in each data source, and of using such a summary as an (additional) source selection criterion in order to reduce the set of sources that will be tested as potentially holding relevant data. We present our source selection method, and we discuss its correctness and implementation. Results: We evaluate the proposed source selection using three different types of summaries with different degrees of accuracy, against not using geospatial summaries. We use datasets and queries from a practical use case that combines crop-type data with water availability data for food security. The experimental results suggest that more complex summaries lead to slower source selection times, but also to more precise exclusion of unneeded sources. Moreover, we observe the source selection runtime is (partially or fully) recovered by shorter planning and execution runtimes. As a result, the federated sources are not burdened by pointless querying from the federation engine. Conclusions: The evaluation draws on data and queries from the agroenvironmental domain and shows that our source selection method substantially improves the effectiveness of federated GeoSPARQL query processing.
Disaggregated optical-layer switching for optically composable disaggregated computing [Invited]
Authors: Ishii Kiyo , Matsumoto Ryosuke , Inoue Takashi , Namiki Shu 
Published: October 2022

Disaggregated computing has been widely investigated to support the continuous progress in computing performance and overcome the slowdown of Moore’s law. It involves a flexible and optimal interconnection of heterogeneous compute nodes, such as the CPU, GPU, xPU, memory, and storage, to offer an efficient computing environment for various applications. Such a scheme inherently requires high network performance, including low latency, high capacity, determinism, and energy efficiency, all of which are simultaneously achieved through the introduction of optical-layer switching. This paper presents the application of optical-layer-switching architectures to disaggregated computing. Networks associated with disaggregated computing are classified into intra- and interserver networks. Focusing on the intraserver network, a holistic concept of optically composable disaggregated computing (OCDC) is discussed, along with its technological direction toward future digital infrastructure (i.e., the computing continuum). To realize OCDC, scalable and flexible optical switch technologies, as well as their dynamic and automatic control and management mechanisms, are indispensable. Previous studies have reported

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silicon photonic switches that can form a nine-stage Clos topology with a radix of 131,072 and a machine-processable function description model for optical-layer switching, called the functional block-based disaggregation model (FBD model) that is capable of automating the operation, administration, and management of any optical physical topology in cooperation with upper-layer operating systems. This study examines their applicability to OCDC. The superior energy performance and scaling of an OCDC system equipped with optical matrix switches, such as silicon photonic switches, with respect to the conventional one big electrical packet-switching approach based on the reported wall-plug power consumption is also presented. The potential applicability of the FBD model as an essential control and management system for the optical layer of OCDC is evaluated through numerical experiments.