bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERANCANGAN MARKETING INFORMATION SYSTEM UNTUK MENINGKATKAN PENJUALAN PRODUK SEPATU TOMKINS BERBASIS ANDROID
Authors: . Riyanto , Aman Mustar 
Published: November 2022

PT. Primarindo Asia Infrastructure, Tbk merupakan Perusahaan multinasional yang bergerak dibidang manufaturing alas kaki. Produk yang dihasilkan oleh Perusahaan tersebut berupa sepatu, sandal, kaus kaki, tas dan beberapa apharel. Salah satu produk yang dihasilkan dan sangat populer di masyarakat Indonesia adalah Tomkins. Tomkins menjadi merk lokal yang sangat diperhitungkan diantara kompetitornya karena produknya memiliki kualitas dan desain yang sangat bervariasi serta menggunakan material lokal yang tidak kalah dengan dengan Merk populer Internasional lainnya.Penjualan produknya dilakukan melalui 3 metode, yaitu Direct Selling, Consignment dan Penjualan Online. Penjualan Online menggunakan 2 line, yaitu menggunakan line web Perusahaan sendiri dan bekerjasama dengan beberapa Online store yang ada di Indonesia. Sistem perekaman data penjualan menggunakan sms gateway yang terintegrasi dengan server Perusahaan, yang dalam implementasinya sering terjadi kesalahan pengiriman format dan layanan operator yang sering error. Masalah tersebut mengakibatkan keterlambatan dalam pengolahan data dan pembuatan laporan dalam mendukung strategi peningkatan penjualan. Berdasarkan hasil analisa yang dilakukan di PT. Primarindo Asia Infrastructure, Tbk terutama pada Divisi Marketing, maka penulis simpulkan bahwa terjadi permasalahan pada pengolahan data penjualan sehingga berpengaruh terhadap strategi peningkatan penjualan yang berdampak pada penurunan profit.Penelitian ini bertujuan membuat suatu sistem yang mampu merekam data secara cepat dan akurat untuk pembuatan laporan penjualan serta mampu menyajikan informasi stok secara up to date sehingga peningkatan penjualan dapat dicapai. Hasil dari penelitian ini berupa aplikasi front end berbasis Android yang akan diinstall pada handphone sales yang ada di semua store di Seluruh Indonesia sehingga meminimalisir kesalah format pengiriman pelaporan dan keterlambatan dalam perekaman data penjualan.Kata kunci: System, Marketing, Information, Android
Marine or freshwater: the role of ornamental fish keeper’s preferences in the conservation of aquatic organisms in Brazil
Authors: Borges Anna Karolina Martins , Oliveira Tacyana Pereira Ribeiro , Alves Rômulo Romeu Nóbrega 
Published: November 2022

BackgroundThe use of ornamental fish as pets has important implications for the conservation of the species used in fish keeping, particularly in relation to overexploitation. Understanding ornamental fish keepers’ relationship with the hobby can provide important information for assessing the potential impacts of the activity. Here, we analyzed the profile of Brazilian ornamental fish keepers and evaluated their preferences and the implications of their choices.MethodsInformation was obtained by applying questionnaires to 906 ornamental fish keepers participating in fish keeping groups in a social network. The questionnaire contained questions about the species of fish kept (freshwater and marine), techniques used, socio-economic aspects, and associated conservation perspectives.ResultsMost ornamental fish keepers were young men (20–40 years old), with higher education and monthly income above US$ 530.00. Participants predominantly kept freshwater fish (86%), but marine fish only (5%) or both marine and freshwater hobbyists (9%) were also recorded. A total of 523 species of ornamental fish were kept, most of which comprised freshwater (76% of the total) and exotic species (73%). About a third of the fish species recorded were under national trade restrictions. In addition, about a third of ornamental fish keepers declared that they also had invertebrates. Marine aquariums require a greater financial investment, especially at the beginning, than freshwater aquariums and are also almost entirely based on exotic species. The aesthetic factor is the main motivation associated with practicing this hobby, being color and behavior key factors in choosing fish. A total of 10% of hobbyists have already released fish into the wild, highlighting concerns about potential biological invasions. There is an urgent need to enforce regulations towards restricting ornamental fish keepers’ access to threatened native species and potentially invasive species, as well as measures aimed at informing and raising hobbyists’ awareness of conservation measures related to the hobby.
Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021
Authors: Jollis James G. , Granger Christopher B. , Zègre-Hemsey Jessica K. , Henry Timothy D. , Goyal Abhinav , Tamis-Holland Jacqueline E. , Roettig Mayme Lou , Ali Murtuza J. , French William J. , Poudel Ram , Zhao Juan , Stone R. Harper , Jacobs Alice K. 
Published: November 2022

ImportanceRecognizing the association between timely treatment and less myocardial injury for patients with ST-segment elevation myocardial infarction (STEMI), US national guidelines recommend specific treatment-time goals.ObjectiveTo describe these process measures and outcomes for a recent cohort of patients.Design, Setting, and ParticipantsCross-sectional study of a diagnosis-based registry between the second quarter of 2018 and the third quarter of 2021 for 114 871 patients with STEMI treated at 648 hospitals in the Get With The Guidelines–Coronary Artery Disease registry.ExposuresSTEMI or STEMI equivalent.Main Outcomes and MeasuresTreatment times, in-hospital mortality, and adherence to system goals (75% treated ≤90 minutes of first medical contact if the first hospital is percutaneous coronary intervention [PCI]-capable and ≤120 minutes if patients require transfer to a PCI-capable hospital).ResultsIn the study population, median age was 63 (IQR, 54-72) years, 71% were men, and 29% were women. Median time from symptom onset to PCI was 148 minutes (IQR, 111-226) for patients presenting to PCI-capable hospitals by emergency medical service, 195 minutes (IQR, 127-349) for patients walking in, and 240 minutes (IQR, 166-402) for patients transferred from another hospital. Adjusted in-hospital mortality was lower for those treated within target times vs beyond time goals for patients transported via emergency medical services (first medical contact to laboratory activation ≤20 minutes [in-hospital mortality, 3.6 vs 9.2] adjusted OR, 0.54 [95% CI, 0.48-0.60], and first medical contact to device ≤90 minutes [in-hospital mortality, 3.3 vs 12.1] adjusted OR, 0.40 [95% CI, 0.36-0.44]), walk-in patients (hospital arrival to device ≤90 minutes [in-hospital mortality, 1.8 vs 4.7] adjusted OR, 0.47 [95% CI, 0.40-0.55]), and transferred patients (door-in to door-out time &amp;lt;30 minutes [in-hospital mortality, 2.9 vs 6.4] adjusted OR, 0.51 [95% CI, 0.32-0.78], and first hospital arrival to device ≤120 minutes [in-hospital mortality, 4.3 vs 14.2] adjusted OR, 0.44 [95% CI, 0.26-0.71]). Regardless of mode of presentation, system goals were not met in most quarters, with the most delayed system performance among patients requiring interhospital transfer (17% treated ≤120 minutes).Conclusions and RelevanceThis study of patients with STEMI included in a US national registry provides information on changes in process and outcomes between 2018 and 2021.
Transfer Hydrogenation in Mesoporous Palladium: Polar Hydrogen Engineering to Realize High Selectivity of Alkyne Semi‐Hydrogenation
Authors: Qin Huaiyu , Liu Ben 
Published: November 2022

AbstractSemi‐hydrogenation of alkynes to industrially important alkenes is earnestly desirable in the fine chemical industry but energetically unfavorable. Herein, it is reported that mesoporous palladium (meso‐Pd) catalyst changes the hydrogenation pathways in ethanol with ammonium borane as the hydrogen source, realizing the high catalytic selectivity of ≈99% in semi‐hydrogenation of alkynes. Mechanism studies reveal that the active polar hydrogen can be produced and reserved well in the electron‐rich mesoporous channels of meso‐Pd catalyst, resulting in a transfer hydrogenation pathway, which selectively semi‐hydrogenates alkynes into alkenes without over‐hydrogenating alkenes into alkanes. Moreover, it is demonstrated that the polar hydrogen engineering of meso‐Pd catalyst is highly efficient in various alkyne semi‐hydrogenation and chemoselective hydrogenation reactions. The results thus establish metal catalyst mesostructuring as an alternative route for engineering polar hydrogen in the transfer hydrogenation reactions, thus realizing the high catalytic selectivity in various selective catalysis.
Atroposelective Synthesis of Tetrahydropyrrolo[3,2‐c]azepine Derivatives Through Gold(I)‐Catalyzed Hydroarylation
Authors: Gaignard‐Gaillard Quentin , Han Xu , Alix Aurélien , Bour Christophe , Guillot Regis , Gandon Vincent , Voituriez Arnaud 
Published: November 2022

AbstractA series of enantioenriched substituted tetrahydropyrrolo[3,2‐c]azepine products possessing an axial chirality were synthesized in 63–99% yield through a gold(I)‐catalyzed hydroarylation. DFT calculations rationalized the reactivity observed for the formation of such complex molecular frameworks and guided our choice in the pyrrole N‐substituent to isolate configurationally stable compounds.magnified image
Cu(I)‐Catalyzed Oxytrifluoromethylation of N‐Boc‐Ynamides for the Construction of Trifluoromethylated Oxazolones
Authors: Zuo Yue , Ye Xingyuan , Jiang Dongjie , Zhou Shuai , Yu Mengyuan , He Guangke 
Published: November 2022

AbstractA chemo‐selective copper(I)‐catalyzed oxytrifluoromethylation of N‐Boc‐ynamides with TMSCF3 has been achieved, affording the trifluoromethylated oxazolones in 51–99% yields. The reaction proceeds at room temperature and tolerates a variety of functional groups such as −X, −OMe, alkenyl, and other substituents. The resulting oxazolones provide access to α‐CF3‐substituted amines through decarboxylative reduction.magnified image
Gold(I)‐Catalyzed Carbothiolation via Rearrangement of S‐Propargyl Group: An Access to 3‐Allenyl or 3‐Indenyl Benzo[b]thiophenes
Authors: Van Wesemael Camille , Brach Nicolas , Gulea Mihaela , Blond Gaëlle 
Published: November 2022

AbstractA series of 3‐allenyl benzo[b]thiophenes were synthesized through a gold(I)‐catalyzed domino reaction. The process consists in a 5‐endo‐dig cyclization with C−S bond formation and consecutive S‐to‐C propargyl migration via [3,3]‐sigmatropic Claisen rearrangement. With aryl substituents on both triple bonds of the substrate, subsequent intramolecular hydroarylation on the formed allenyl system led to 3‐indenyl benzo[b]thiophenes. From a substrate bearing a 3‐butynol moiety diverse fused O‐heterocycles have been obtained via intramolecular hydroalkoxylation. A gold‐mediated 1,3‐migration involving allenyl to propargyl rearrangement is also described.magnified image
Benefits of an Immunogenic Personalized Neoantigen Nanovaccine in Patients with High‐Risk Gastric/Gastroesophageal Junction Cancer
Authors: Liu Qin , Chu Yanhong , Shao Jie , Qian Hanqing , Yang Ju , Sha Huizi , Cen Lanqi , Tian Manman , Xu Qiuping , Chen Fangjun , Yang Yang , Wang Weifeng , Wang Kai , Yu Lixia , Wei Jia , Liu Baorui 
Published: November 2022

AbstractPersonalized neoantigen vaccines have shown strong immunogenicity in clinical trial, but still face various challenges in facilitating an efficient antitumor immune response. Here, a personalized neoantigen nanovaccine (PNVAC) platform for adjuvant cancer immunotherapy is generated. PNVAC triggers superior protective efficacy against tumor recurrence and promotes longer survival than free neoantigens, especially when combined with anti‐PD‐1 treatment in a murine tumor model. A phase I clinical trial (ChiCTR1800017319) is initiated to evaluate the safety, immunogenicity, and prophylactic effect of PNVAC on preventing tumor recurrence in patients with high‐risk gastric/gastroesophageal junction cancer after adjuvant chemotherapy of postsurgical resection. The one‐ and two‐year disease‐free survival rates are significantly higher than historical record. PNVAC induces both CD4+ and CD8+ T cell responses as well as antigen‐experienced memory T cell phenotype. Furthermore, the immune response is persistent and remains evident one year after the vaccination. This work provides a safe and feasible strategy for developing neoantigen vaccines to delay gastric cancer recurrence after surgery.
Soybean seeding rate and seed treatment that maximize yield and profitability based on planting date
Authors: Siler Thomas B. , Singh Maninder Pal 
Published: November 2022

AbstractWarmer spring temperatures and a growing body of literature on the importance of timely planting have resulted in many growers in Michigan and other northern U.S. states planting soybean [Glycine max (L.) Merr.]. However, there is limited research in Michigan informing how other management practices should be adjusted based on planting date (PD). Field experiments were conducted at two locations in Michigan using a split‐plot design during the 2018 and 2019 growing seasons to determine how seeding rate (SR; 124,000 to 519,000 seeds ha−1) and seed treatment (ST; fungicide + insecticide + nematicide) impact soybean yield and net returns based on PD. Soybean was planted at five SRs with or without an ST (split‐plot) on four PDs (main‐plot). The use of the ST increased plant stand by 6.7% at one location but did not improve yield at either location regardless of PD. The increased cost associated with the ST and lack of a yield increase resulted in a US$25 ha−1 decrease in net returns. Maximum yield was achieved with a final plant stand of 242,000, 288,000, 307,000, and 384,000 plants ha−1 during the late April, mid‐May, early June, and late June PDs, respectively. However, the final population to achieve maximum net returns ranged from 89,000 to 141,000 plants ha−1 less than the population that maximized seed yield. Overall, results indicated that ST did not improve net returns across any PD, and relatively lower SRs were able to achieve maximum yield and net returns during early season planting, but increased SRs were necessary when planting was delayed.
Effectiveness of nutritional information in increasing demand for enriched yoghurt among poor households in Kenya: Implications for agribusiness marketing strategies
Authors: Ortega David L. , Caputo Vincenzina , Maredia Mywish 
Published: November 2022

AbstractThe yoghurt market represents one of the most dynamic consumer segments in Kenya's dairy industry. Product innovation like yoghurt enriched with nutrients is increasingly promoted to address the challenges of micro‐nutrient deficiencies, especially among children and women of poor households. Using data from 383 in‐household interviews in predominantly poor neighborhoods in Nairobi, we focus on evaluating features that can make this healthy product more desirable to increase demand and inform agribusiness marketing efforts. More specifically, we elicit preferences and willingness to pay (WTP) for health and nutrition‐related yoghurt product attributes, and find that information connecting product enrichment to health can increase consumer desirability and consumer WTP. [EconLit Citations: D12, Q10, Q13].
Mindestinformationsstandards in der Chemie: Ein Appell zum besseren Umgang mit Forschungsdaten
Authors: Herres‐Pawlis Sonja , Bach Felix , Bruno Ian J. , Chalk Stuart J. , Jung Nicole , Liermann Johannes C. , McEwen Leah R. , Neumann Steffen , Steinbeck Christoph , Razum Matthias , Koepler Oliver 
Published: November 2022

AbstractForschungsdatenmanagement (FDM) ist erforderlich, um wissenschaftlichen Fortschritt und das Sammeln von Daten zu fördern. Viele Fördergeldgeber verlangen FDM, da Forschung oft durch Steuergelder finanziert wird und daraus resultierende Daten nachhaltig für kommende Generationen hinterlegt werden sollten. In heutigen Laboren sind Papier‐Laborbücher allerdings noch immer gängige Praxis, und die Forschungsdaten werden oft in proprietären Dateiformaten ohne experimentellen Kontext gespeichert. Daten müssen über eine Rolle als bloßes Anhängsel von Publikationen hinauswachsen. Elektronische Laborbücher (ELN) und Laborinformationsmanagementsysteme (LIMS) ermöglichen es, Daten besser zu verwalten sowie Forschung und Veröffentlichung zu vereinfachen. Die in gutes FDM investierte Zeit zahlt sich später in vielerlei Hinsicht aus. Daher werden Mindestinformationsstandards (MI) für die Handhabung von Daten benötigt. Die Digitalisierung hält gerade Einzug in die Lehrpläne, sodass zukünftige Generationen von ChemikerInnen mit FDM und ELN‐Nutzung vertraut sein werden.
Molecular Engineering of Chalcogen‐Embedded Anthanthrenes viaperi‐Selective C−H Activation: Fine‐Tuning of Crystal Packing for Organic Field‐Effect Transistors
Authors: Liu Zheng , Han Weiguo , Lan Jingbo , Sun Lingyan , Tang Junbin , Zhang Cheng , You Jingsong 
Published: November 2022

AbstractDisclosed herein is a RhCl3‐catalyzedperi‐selective C−H/C−H oxidative homo‐coupling of 1‐substituted naphthalenes, which provides a highly efficient and streamlined approach to chalcogen‐embedded anthanthrenes from readily available starting materials. Introducing O, S, and Se into the anthanthrene skeleton leads to gradually increased π–π stacking distances but significantly enhanced π–π overlaps with the growth of the hetero‐atom radius. Moderate π–π distance, overlap area, and intermolecular S−S interactions endow S‐embedded anthanthrene (PTT) with excellent 2D charge‐transport properties. Moreover, the transformation of p‐type to n‐type S‐embedded anthanthrenes is realized for the first time via the S‐atom oxidation fromPTTtoPTT‐O4. In organic field‐effect transistor devices,PTTderivatives exhibit hole transport with mobilities up to 1.1 cm2 V−1 s−1, whilePTT‐O4shows electron transport with a mobility of 0.022 cm2 V−1 s−1.
Synthetic Zwitterionic Streptococcus pneumoniae Type 1 Oligosaccharides Carrying Labile O‐Acetyl Esters
Authors: Wang Zhen , Gimeno Ana , Lete Marta G. , Overkleeft Herman S. , van der Marel Gijsbert A. , Chiodo Fabrizio , Jiménez‐Barbero Jesús , Codée Jeroen D. C. 
Published: November 2022

AbstractWe herein report the first total synthesis of the Streptococcus pneumoniae serotype 1 (Sp1) oligosaccharide, a unique zwitterionic capsular polysaccharide carrying labile O‐acetyl esters. The target oligosaccharides, featuring rare α‐2,4‐diamino‐2,4,6‐trideoxy galactose (AAT) and α‐galacturonic acids, were assembled up to the 9‐mer level, in a highly stereoselective manner using trisaccharide building blocks. The lability of the O‐acetyl esters imposed a careful deprotection scheme to prevent migration and hydrolysis. The migration was investigated in detail at various pD values using NMR spectroscopy, to show that migration and hydrolysis of the C‐3‐O‐acetyl esters readily takes place under neutral conditions. Structural investigation showed the oligomers to adopt a right‐handed helical structure with the acetyl esters exposed on the periphery of the helix in close proximity of the neighboring AAT residues, thereby imposing conformational restrictions on the AATα1‐4GalA(3OAc) glycosidic linkages, supporting the helical shape of the polysaccharide, that has been proposed to be critical for its unique biological activity.
Catalytic DNA‐Assisted Mass Production of Arbitrary Single‐Stranded DNA
Authors: Zhang Qiao , Xia Kai , Jiang Meng , Li Qingting , Chen Weigang , Han Mingzhe , Li Wei , Ke Rongqin , Wang Fei , Zhao Yongxing , Liu Yuehua , Fan Chunhai , Gu Hongzhou 
Published: November 2022

AbstractSynthetic single‐stranded (ss) DNA is a cornerstone for life and materials science, yet the purity, quantity, length, and customizability of synthetic DNA are still limiting in various applications. Here, we present PECAN, paired‐end cutting assisted by DNAzymes (DNA enzymes or deoxyribozymes), which enables mass production of ssDNA of arbitrary sequence (up to 7000 nucleotides, or nt) with single‐base precision. At the core of PECAN technique are two newly identified classes of DNAzymes, each robustly self‐hydrolyzing with minimal sequence requirement up‐ or down‐stream of its cleavage site. Flanking the target ssDNA with a pair of such DNAzymes generates a precursor ssDNA amplifiable by pseudogene‐recombinant bacteriophage, which subsequently releases the target ssDNA in large quantities after efficient auto‐processing. PECAN produces ssDNA of virtually any terminal bases and compositions with >98.5 % purity at the milligram‐to‐gram scale. We demonstrate the feasibility of using PECAN ssDNA for RNA in situ detection, homology‐directed genome editing, and DNA‐based data storage.
Chemoselective Decarboxylative Protonation Enabled by Cooperative Earth‐Abundant Element Catalysis
Authors: Lu Yen‐Chu , West Julian G. 
Published: November 2022

AbstractDecarboxylative protonation is a general deletion tactic to replace polar carboxylic acid groups with hydrogen or its isotope. Current methods rely on the pre‐activation of acids, non‐sustainable hydrogen sources, and/or expensive/highly oxidizing photocatalysts, presenting challenges to their wide adoption. Here we show that a cooperative iron/thiol catalyst system can readily achieve this transformation, hydrodecarboxylating a wide range of activated and unactivated carboxylic acids and overcoming scope limitations in previous direct methods. The reaction is readily scaled in batch configuration and can be directly performed in deuterated solvent to afford high yields of d‐incorporated products with excellent isotope incorporation efficiency; characteristics not attainable in previous photocatalyzed approaches. Preliminary mechanistic studies indicate a radical mechanism and kinetic results of unactivated acids (KIE=1) are consistent with a light‐limited reaction.
Anthracene‐Fused Oligo‐BODIPYs: A New Class of π‐Extended NIR‐Absorbing Materials
Authors: Labella Jorge , Durán‐Sampedro Gonzalo , Krishna Swathi , Martínez‐Díaz M. Victoria , Guldi Dirk M. , Torres Tomás 
Published: November 2022

AbstractLarge π‐conjugated systems are key in the area of molecular materials. Herein, we prepare via AuI‐catalyzed cyclization a series of fully π‐conjugated anthracene‐fused oligo‐BODIPYs. Their structural and optoelectronic properties were studied by several techniques, ranging from X‐ray, UV/Vis, and cyclic voltammetry to transient absorption spectroscopy. As a complement, their electronic structures were explored by means of Density Functional Theory (DFT) calculations. Depending on the size and shape of the π‐conjugated skeleton, unique features—such as face‐to‐face supramolecular organization, NIR absorption and fluorescence as well as strong electron accepting character—were noted. All in all, the aforementioned features render them valuable for technological applications.
Organocatalytic Enantioselective Diels–Alder Reaction of 2‐Trifluoroacetamido‐1,3‐dienes with α,β‐Unsaturated Ketones
Authors: Zhu Xin‐Qi , Wang Qian , Zhu Jieping 
Published: November 2022

AbstractWe report herein the first examples of chiral phosphoric acid‐catalyzed enantioselective Diels–Alder reactions between 2‐trifluoroacetamido‐1,3‐dienes 1 and α,β‐unsaturated carbonyl compounds 2. Polysubstituted 1‐acetamido cyclohexenes 3 were formed in high yields with excellent diastereo‐ and enantioselectivities. The reaction proceeds through a stepwise process as shown by deuterium labelling experiments. A catalytic enantioselective three‐component reaction of 1, 2 and ortho‐hydroxybenzhydryl alcohols 4 was subsequently developed furnishing the densely functionalized hexahydroxanthenes 5 in a highly stereoselective manner. This multicomponent reaction generates four chemical bonds with concurrent creation of five contiguous stereocenters.