bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear Love-Type Waves in a Heterogeneous Layer Sandwitched Between TwoSemi-Infinite Media
Authors: Ozdemir Ekin Deliktas 
Published: October 2022

Abstract
Generalized Love-type wave propagation in a nonlinear, heterogeneous, isotropic, low-velocity intermediate layer of uniform thickness lying between two nonlinear, homogeneous, elastic different half spaces is examined. The heterogeneity of the layer is considered to result from the exponential change of rigidity and density in the thickness direction. Nonlinear self-modulation of waves is characterized by a nonlinear Schrödinger equation with the aid of multiple scales asymptotic method. The influence of both nonlinearand heterogeneous characteristics of the slow intermediate layer on the existence of bright and dark soliton Love-type waves is investigated numerically. Furthermore, the considerable effect of the layer’s linear and nonlinear heterogeneity properties on the nonlinear evolution of bright and dark solitary waves is graphically shown.
Microbial community succession along a chronosequence in constructed salt marsh soils
Authors: Kim Carol , Staver Lorie W. , Chen Xuan , Bulseco Ashley , Cornwell Jeffrey C. , Malkin Sairah Y. 
Published: October 2022

Abstract
In this study, we examined the succession of soil microbial communities across a chronosequence of newly constructed salt marshes constructed primarily of fine-grained dredge material, using 16S rRNA amplicon sequences. Alpha diversity in the parent material was initially low and increased to reference levels within 3 years of marsh construction, while in the newly accumulating organic matter-rich surface soils alpha diversity was initially high and remained unchanged. Microbial community succession was fastest in the surface horizon (~ 24 years to reference equivalency) and became progressively slower with depth in the subsurface horizons (~ 30–67 years). Random forest linear regression analysis was used to identify important taxa driving the trajectories toward reference conditions. In the parent material, putative sulfate-reducers (Desulfobacterota), methanogens (Crenarchaeota, especially Methanosaeta), and fermenters (Chloroflexi and Clostridia) increased over time, suggesting an enrichment of these metabolisms over time, similar to natural marshes. Concurrently in the surface soils, the relative abundances of putative methane-, methyl-, and sulfide oxidizers, especially among Gammaproteobacteria, increased over time, suggesting the co-development of sulfide and methane removal metabolisms in the marsh soils. Finally, we observed that the surface soil communities at one of the marshes did not follow the trajectory of the others, exhibiting a greater relative abundance of anaerobic taxa. Uniquely in this dataset, this marsh was developing signs of excessive inundation stress in terms of vegetation coverage and soil geochemistry. Therefore, we suggest that soil microbial community structures may be effective bioindicators of salt marsh inundation and are worthy of further targeted investigation.
The development of radiotherapy quality indicators for lung cancer- a modified Delphi technique protocol
Authors: Chiew Kim-Lin , Donnelly Candice , Harden Susan , Vinod Shalini 
Published: October 2022

Abstract
Background
Radiotherapy is an effective evidence-based treatment modality for the definitive management of both early and locally advanced lung cancer. Whilst the literature reports a wide range of quality indicators (QIs) to assess the surgical management of lung cancer there is a deficit of robust QIs available to measure the quality of radiotherapy received by patients[1]. We propose a literature review and modified Delphi technique to develop a set of radiotherapy specific quality indicators and benchmarks aimed at evaluating the processes involved in the planning and delivery of radiotherapy for lung cancer.
Methods
A modified Delphi technique will be used and will include an international expert panel in two formal rounds with a target of 40 participants and intervening steering committee review with a minimum of 9 stakeholders. Candidate radiotherapy QIs will be selected from literature review and assessed by a steering committee to be included in the Delphi process. Both QIs and proposed benchmarks will be ranked by the expert panel in 2 rounds and included in the final set of QIs if a pre-defined consensus definition for importance is met by at least 70% of responses with a score of 7 or more on a 9-point Likert scale. Consensus criteria for feasibility and proposed benchmarks will be achieved if at least 70% of responses are reported as 3 or more on a 3-point Likert scale.
Discussion
We aim to address the current lack of quality indicators for assessing radiotherapy in lung cancer by using a robust modified Delphi method to attain international expert consensus for a set of QIs specific to the process involved in planning and delivering radiotherapy for definitive management of lung cancer. These have the potential to provide a foundation for QI measurement and benchmarking to guide quality improvement in radiotherapy for lung cancer.
Do different methods of specimen extraction in laparoscopic low rectal cancer surgery affect loop ileostomy closure?
Authors: Chen Haipeng , Huang Fei , Yang Ming , Zhao Zhixun , Guan Xu , Liu Zheng , Jiang Zheng , Liu Qian , Zheng Zhaoxu , Wang Xishan 
Published: October 2022

Abstract
Introduction: The aim of this study was to compare whether laparoscopic low rectal cancer surgery with three different specimen extraction methods affects loop ileostomy closure.
Materials and methods: A consecutive series of patients with low rectal cancer who underwent laparoscopic low anterior resection plus protective loop ileostomy (LAR-PLI) were enrolled. Three main techniques, namely specimen extraction through auxiliary incision (EXAI), specimen extraction through stoma incision (EXSI), and specimen eversion and extra-abdominal resection (EVER), were employed. The postoperative outcomes of the three techniques and the impact on loop ileostomy closure were compared.
Results: In all, 254 patients were enrolled in this study: 104 (40.9%) in the EXAI group, 104 (40.9%) in the EXSI group, and 46 (18.1%) in the EVER group. For primary surgery, EXAI group had significantly longer operative time (P<0.001), more intraoperative bleeding (P<0.001), longer length of abdominal incision (P＜0.001), longer time to first flatus (P<0.001), longer time to first defecation (P<0.001), longer time to first eat (P<0.001), and longer postoperative hospital stays (P=0.005) than the EXSI and EVER groups. The primary postoperative complication rate in the EXAI and EVER group was significantly higher than in the EXSI group (P=0.005). In loop ileostomy closure, EXAI group had significantly longer operative time (P=0.001), more bleeding volume and longer postoperative hospital stays (P<0.001) than the EXSI and EVER groups.
Conclusions: All three techniques of LAR-PLI for low rectal cancer were safe and feasible, but specimen extraction via EXAI had no advantages in terms of early postoperative recovery and loop ileostomy closure.
Cohort Profile: CITIC-Xiangya Assisted Reproductive Technology Cohort (CXART Cohort)
Authors: Ma Shujuan , Xiong Yiquan , Hu Liang , Peng Yangqin , Wang Xiaojuan , Tan Lu , Hocher Berthold , Sun Xin , Tan Jing , Lin Ge 
Published: October 2022

Abstract
To address the data source gap between the wide use of assisted reproductive technology (ART) and deficiencies in clinical and biological research, the CITIC-Xiangya Assisted Reproductive Technology (CXART) Cohort began to enroll infertile patients who attended the Reproductive and Genetic Hospital of CITIC-Xiangya for ART treatment since January 2016, and enrollment is expected to be completed in January 2026. By November 30, 2020, 223,494 ART cycles were recorded from 119,590 infertile couples. In addition to the detailed medical, treatment and laboratory records, examination and detection results, billing information captured from the hospital’s pre-designed and ART-specialized electronic medical records system; and follow-up data at four time points (14 and 28 days after transfer, 42 days and 1 year after delivery) collected by the active follow-up team, we also investigated lifestyle habits, environmental exposure, dietary nutrition and psychological emergencies of 26,747 infertile couples by proactive investigation. To date, a total of 71,689 biological samples have been collected from infertile couples, including peripheral blood, follicular fluid, cumulus cells, and semen. The cohort has the capacity to examine the causes and elucidate the mechanisms of infertility, novel therapeutic targets, and better reproductive outcomes, and provides a theoretical basis for the exploration of personalized precision medicine, especially in Chinese populations.
The Knowledge Mapping of HIV/AIDS in Indonesians Living on Six Major Islands Using the Indonesian Version of the HIV-KQ-18 Instrument
Authors: Arifin Bustanul , Rokhman M. Rifqi , Zulkarnain Zulkarnain , Perwitasari Dyah Aryani , Manggau Marianti , Rauf Saidah , Noor Rasuane , Padmawati Retna Siwi , Massi Muhammad Narum , Schans Jurjen van der , Postma Maarten J. 
Published: October 2022

Abstract

Background
Indonesia's total number of HIV/AIDS cases is still high. Inadequate knowledge about the risk of HIV infection will influence HIV prevention and therapy. This study aimed to map the level of HIV-related knowledge among Indonesians living on six major islands in Indonesia and investigate the relationship between socio-demographic characteristics and HIV/AIDS knowledge.
Methods
This cross-sectional study used the Bahasa Indonesia version of the HIV Knowledge Questionnaire-18 items (HIV-KQ-18) Instrument. Data collection was done online through the Google form application.
Results
A total of 5,364 participants were recruited. The participants from Java had the highest degree of HIV/AIDS knowledge, which was 12.5% higher than participants from Sumatra, Kalimantan, Sulawesi, Papua, and Maluku. Linear regression showed that region, educational level, monthly expenditure, occupation, background in health sciences, and workshop attendance were significantly correlated with HIV knowledge. Participants typically understand that "HIV/AIDS transmission" only happens when sex partners are changed. Additionally, the government still needs improvement in HIV/AIDS education, particularly in the HIV incubation period, HIV transmission from pregnant women to the fetus, and condom use as one method of protection.
Conclusion
There are disparities in HIV/AIDS knowledge levels among the major islands of Indonesia. Based on these findings, the government's health promotion program to increase public awareness of HIV/AIDS must be implemented vigorously. Additionally, in line with our research findings, it is essential to broaden the scope of HIV/AIDS education and promotion materials.
A randomized Multi-index sequential Monte Carlo method
Authors: Cotter Simon L. , Law Kody J. H. , Liang Xinzhu , Yang Shangda 
Published: October 2022

Abstract
We consider the problem of estimating expectations with respect to a target distribution with an unknown normalizing constant, and where even the unnormalized target needs to be approximated at finite resolution. Under such an assumption, this work builds upon a recently introduced multi-index Sequential Monte Carlo (SMC) ratio estimator, which provably enjoys the complexity improvements of multi-index Monte Carlo (MIMC) and the efficiency of SMC for inference. The present work leverages a randomization strategy to remove bias entirely, which simplifies estimation substantially, particularly in the MIMC context, where the choice of index set is otherwise important. Under reasonable assumptions, the proposed method provably achieves the same canonical complexity of MSE$^{-1}$ as the original method, but without discretization bias. It is illustrated on examples of Bayesian inverse problems.
FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis
Authors: Dong Qingtai , Ma Dandan , Gong Qi , Lin Zhenyu , Li Zhonghu , Ye Jiaxin , Qin Chunhui , Jin Weidong , Zhang Jianxin , Zhang Zhiyong 
Published: October 2022

Abstract
Background: Family with sequence similarity three member (FAM3) plays a crucial role in the malignant development of various cancers of human. Our study aimed to investigate the role of FAM3 family genes in prognosis, immune subtype, tumor immune microenvironment, stemness score, and anticancer drug sensitivity of pan-cancer.
Methods: The expression, survival, immune subtype, tumor microenvironment, stemness score, and anticancer drug sensitivity analysis data of FAM3 family genes associated with pan-cancer from UCSC Xena GDC and CellMiner databases. Furthermore, we investigated the tumor cellular functions and clinical prognostic value FAMC3 in pancreatic cancer (PAAD) using cellular experiments and tissue microarray.
Results: The results revealed that FAM3 family genes are significantly differential expression in tumor and adjacent normal tissues in 7 cancers (CHOL, HNSC, KICH, LUAD, LUSC, READ, and STAD). The expression of FAM3 family genes were negatively related with the RNAss, and robust correlated with immune type, tumor immune microenvironment and drug sensitivity. Meanwhile, overexpression FAM3C promoted PAAD cell proliferation, migration, invasion and suppressed PAAD cell apoptosis. While knockdown of FAM3C triggered opposite results. High FAM3C expression was associated with duodenal invasion, differentiation and liver metastasis.
Conclusion: This study provided a new perspective on the potential therapeutic role of FAM3 family genes in pan-cancer. In particular, FAM3C may be a new marker for PAAD, providing a new idea for the treatment of PAAD.
Risk assessment of cytologically indeterminate thyroid nodules with integrated molecular testing and repeat biopsy: a surgical decision-oriented tool
Authors: Guan Xuhuizi , Yu Tian , Zhang Zheng , Chen Lan , Yan An , Li Yao , Li Jiankun , Wang Dongdong , Sun Jie , Wang Feiliang , Miao Gang 
Published: October 2022

Abstract
Background: The preoperative diagnosis of cytologically indeterminate thyroid nodules (ITNs) is very challenging. In this study, we aim to provide an integrated risk assessment for thyroid nodules with indeterminate cytology to guide surgical decision-making.
Methods: The study retrospectively included 265 ITNs between June 2019 and April 2022. According to our integrated risk assessment that includes the results of blood tests, molecular tests and repeat fine-needle aspiration biopsy (FNAB), we divided the ITNs into high-risk and low-risk groups. Performance was evaluated with sensitivity, specificity, positive predictive value (PPV), negative predictive value(NPV), area under the receiver operating characteristiccurve (AUC), and the consistency between the risk evaluation and histological results.
Results:Of the 265 ITNs, 87 were included in the risk assessment process. The risk assessment had a sensitivity of 84.1%, specificity of 83.3%, PPV of 95.1%, NPV of 57.7% and AUC of 0.837. The nodules with consistent results between the risk groups and histological outcomes, which included malignant cases in the high-risk group and benign cases in the low-risk group, accounted for 83.9% of all risk-assessed nodules.
Conclusions: These data suggest that the integrated risk assessment might provide proper information for surgical decision-making in patients with ITNs.
Perceptible Sentiment Analysis of Students' WhatsApp Group Chats in Valence, Arousal, and Dominance Space
Authors: Roy Baishali , Das Sourav 
Published: October 2022

Abstract
Sentiment analysis is a vastly established domain for social media monitoring, feedback insights, and commercial or political campaigns, as it allows us to gain an overview of the wider public opinion on certain topics. Nowadays, different social media platforms play a crucial role in web-based sentiment analysis and emotion detection from distinct perspectives. Likewise, WhatsApp is probably the most popular messaging app, allowing users to send messages, images, audio, or videos. However, it is still highly under-explored for any type of linguistic synthesis and analysis. Like many other groups of people, students use WhatsApp for various purposes, even more since the last two years of the pandemic phase. For instance, class communication, study group communication, etc. In this paper, we present a novel approach to analyze the sentiments and emotions of students in valence, arousal, and dominance space by classifying the messages from their WhatsApp group chat. The emotional dimensions of Valence, Arousal and Dominance (VAD) can derive a person’s interest (attraction), level of activation, and perceived level of control for a particular situation from textual communication. We propose a vanilla SVM model fused with a language classifier to calculate each message's sentiment ratings. Finally, using the SVM classifier we classify the sentiment ratings concerning the degree of the VAD scale. The data were analyzed using a qualitative content analysis method. The results of the study in the form of cumulative sentiment scale and sentiment clustering in VAD space reveal that the students' WhatsApp groups were mostly used for sharing information, exchanging ideas, and discussing issues, with mostly neutral to positive sentiment viewpoints for the provided topics of discussions.
A semiautomated radiomics model based on multimodal spectral CT for preoperative discriminating of the invasiveness of pure ground-glass nodules.
Authors: Wang Yue , Chen Hebing , Chen Yuyang , Guang Zhongzhen , Huang Haoyu , Sun Peng , Zhang Xiaohui , Wan Yiliang , Li Lingli , Ye Tianhe , Pan Feng , Yang Lian 
Published: October 2022

Abstract
Background
To investigate the value of dual-layer spectral CT-based multimodal radiomics in accessing the invasiveness of lung adenocarcinoma manifesting as ground glass nodules (GGNs).
Method
In this study, 125 GGNs with pathologically confirmed preinvasive adenocarcinoma and lung adenocarcinoma were divided into a training set (n = 87) and a test set (n = 38). Each lesion was automatically detected and segmented by the pre-trained neural networks (SCPM-Net and 3D-RCNN), and 63 multimodal radiomic features were extracted. The least absolute shrinkage and selection operator (LASSO) was used to select target features, and a rad-score was constructed in the training set. Logistic regression analysis was conducted to establish a joint model which combined age, gender, and the rad-score. Diagnostic performance of the two models were compared by the receiver operating characteristic (ROC) curve and precision-recall (PR) curve. The test set was used to evaluate the predictive performance and calibration of the model.
Results
Five radiomic features (a_ED_original_firstorder_90Percentile, a_ID_original_firstorder_Entropy, p_original_shape_Maximum2DDiameterSlice, v_ED_original_firstorder_90Percentile and v_Zeff_original_firstorder_Uniformity) were selected. In the training and test sets, the AUC of the radiomics model was 0.896 (95% CI: 0.830, 0.962) and 0.881 (95% CI: 0.777, 0.985) respectively, and the AUC of the joint model was 0.932 (95% CI: 0.882–0.982) and 0.887 (95% CI: 0.786, 0.988) respectively. There was no significant difference in AUC between the training and test sets (0.896 vs. 0.932, p = 0.088; 0.881 vs. 0.887, p = 0.480).
Conclusion
Multimodal radiomics based on dual-layer spectral CT showed good predictive performance in differentiating the invasiveness of GGNs, which could assist in the decision of clinical treatment strategies.
Risk factors associated with prolonged postoperative intensive care unit stay in total anomalous pulmonary venous connection
Authors: Huang Jinjin , Tang Jian , Fan Yong , Wang Dongpi , Ye Lifen 
Published: October 2022

Abstract
Objective
Prolonged intensive care unit stay occupies medical resources and increases medical cost. The present study aimed to identify the risk factors associated with prolonged postoperative intensive care unit (ICU) stay in total anomalous pulmonary venous connection (TAPVC).
Methods
The medical records of 85 patients who underwent TAPVC correction surgery were retrospectively analyzed. Patients were divided into the prolonged stay group and the standard stay group. The prolonged stay group included all the patients exceeding the 75th percentile for duration of ICU stay, and the standard stay group included all the remaining patient. The effect of patient variables on the ICU stay duration was investigated using univariate analysis and logistic regression analysis.
Results
The median age of 85 patients was 41 (18–103) days, median weight was 3.80 (3.30–5.35) kg. According to the grouping criteria, the postoperative duration of ICU stay in prolonged stay group (n = 23) was 11–68 days and the postoperative duration of ICU stay in standard stay group (n = 62) was 2–10 days. Preoperative lower saturation of pulse oximetry (SpO2), intraoperative higher plasma lactate level and prolonged postoperative mechanical ventilation were independent risk factors for prolonged ICU stay in children with TAPVC. When the preoperative SpO2 was lower than 88.5%, the highest plasma lactate value was more than 4.15 mmol/L, and the postoperative mechanical ventilator duration was longer than 53.5 hours, the risk of prolonged ICU stay was increased. Young age, low body weight, subcardiac type, need for vasoactive drug support, emergency operation, long anesthesia time, low SpO2 after anesthesia induction, long cardiopulmonary bypass (CPB) time and aortic clamp time, high level lactate, low temperature and large volume of ultrafiltration during CPB, large amount chest drainage, large red blood cells (RBCs) and plasma transfusion, postoperative cardiac dysfunction might be associated with prolonged ICU stay.
Conclusions
Preoperative lower SpO2, intraoperative higher plasma lactate level and prolonged postoperative mechanical ventilation were independent risk factors for prolonged ICU stay in children with TAPVC. When the SpO2 was lower than 88.5%, the highest plasma lactate value was more than 4.15 mmol/L, and the postoperative mechanical ventilator duration was longer than 53.5 hours, the risk of prolonged ICU stay was increased. Improved clinical management including early diagnosis and timely surgical intervention to reduce hypoxia time, intraoperative cardiac function protection, etc. can help to reduce ICU stay time.
High-performance flipped voltage follower based low input resistance current mirror with wide current mirroring range and high output resistance
Authors: Jindal Caffey , Pandey Rishikesh 
Published: October 2022

Abstract
This paper presents a high performance current mirror with a large current mirroring range. The advantages of folded flipped voltage follower (FVF) cell and super cascode transistor are combined in proposed current mirror, which make it suitable for high performance applications. The folded FVF cell provides low resistance node which is utilized to inject the input current and therefore, proposed current mirror shows input resistance of 24.15 Ω. By employing a super cascode transistor at the output node, the output resistance is increased to 28.3 G. The presented current mirror achieves bandwidth of 280 MHz and wide current mirroring range of 0 to 500 µA. The suggested current mirror is designed using CMOS technology at 0.18 µm in virtuoso, and it is simulated using Cadence’s spectre. The physical layout has been made using the layout XL editor. The efficiency of the proposed current mirror is shown by post-layout simulation results.