bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generating a Bispecific Antibody Drug Conjugate Targeting PRLR and HER2 with Improving the Internalization
Authors: Zong Hui-Fang , Zhang Bao-Hong , Zhu Jian-Wei 
Published: July 2022

AbstractAntibody drug conjugate (ADC) therapy has become one of the most promising approaches in cancer immunotherapy. The bispecific targeting could improve the specificity, affinity, and internalization of the ADC molecules. Prolactin preceptor (PRLR) and HER2 have crosstalk signaling in breast cancer, and PRLR undergoes a rapid internalization compared with HER2. To improve the efficacy of HER2 ADCs with enhancing the target specificity and internalization, we constructed a PRLR/HER2-targeting bispecific ADC (BsADC). We evaluated the characterization of PRLR × HER2 BsADC from the affinity and internalization, and further assessed its in vitro cytotoxicity in human breast-cancer cell lines (BT474, T47D, and MDA-MB-231) using Cell Count Kit-8 analysis. Our data demonstrated that PRLR × HER2 BsADC kept the affinity to two targeting antigens after conjugating drugs and exhibited higher internalization efficiency in comparison to HER2 ADC. Furthermore, PRLR × HER2 BsADC demonstrated to have superior antitumor activity in human breast cancer in vitro. In conclusion, our findings indicate that it is feasible through increasing the internalization of target antibody to enhance the antitumor activity and therapeutic potential that could be further evaluated in in vivo animal model.
Using cognitive discourse functions and comparative judgement to build teachers’ knowledge of content and language
integration for assessment in a bilingual education program
Authors: Morton Tom 
Published: July 2022

Abstract
This paper reports a study carried out in the context of a seminar designed to build teachers’ knowledge of
content and language integration for assessment in a bilingual education program in Madrid, Spain. The participants were seven
teachers (two primary, five secondary) of English and science (primary), and art, history, Spanish language arts and English
(secondary). The teachers were introduced to the concept of cognitive discourse function (CDF) and assessed
samples of students’ work expressing the functions define, evaluate, and explore, using
comparative judgement. In sharing and justifying their assessments, they articulated the criteria they used to take their
decisions. The findings show that participants emphasized content quality over quantity and language form over function. There was
also evidence that the concept of CDFs enabled them to express new understandings of the content-language relationship in
assessment. The study has implications for building the knowledge base for content and language integrated assessment across CBLE
programs.
The benefit of urban green area in Kota Kinabalu, Sabah
Authors: Mojiol A R , Lim W S , Chung K C L , Dani J L 
Published: July 2022

Abstract
The city of Kota Kinabalu features several urban green areas, which become the focal points for the urban inhabitants. This study was conducted to determine the benefits and public perceptions that encourage them to visit the local urban green area. The convenience sampling method was used, in which questionnaires were distributed to 101 respondents of the local park visitors. The present finding revealed that most of the respondents strongly agreed that the urban greens help to improve the physical well-being of the urban dwellers (Mean score, µ=4.27), regulate the urban temperature during sunny days (µ=4.20), encourage people to spend more time on outdoor activities in nature (µ=4.14), help to remove air pollutants (µ=4.09), control the amount of water on the ground surface during the rainy season (µ=4.06), reduce stress, anxiety, and depression (µ=4.04), prevent the occurrence of a flash flood (µ=3.98), and promote social interactions among people (µ=3.81). The correlation between the respondents’ education and the mean benefits of urban green areas in Kota Kinabalu was significant (p<0.05). In conclusion, the public perception of the benefits of urban green areas is generally positive, and they also exhibit a high understanding of its importance towards urban dwellers.
Converting wood-related waste materials into other value-added products: A short review
Authors: Mokhtar N , Razali S M , Sulaiman M S , Edin T , Wahab R 
Published: July 2022

AbstractThis paper reviews converting wood-related waste materials from forestry, wood-based industry, and agriculture activities into other value-added products such as bio-energy, construction materials, agricultural compost, and handicraft application. The wood waste, however, needs to be processed before it can be utilized. The information obtained is reviewed in order to enable them to be useful to the government planners and those involved in the wood-based industry. The gross domestic product from the forest-related industry reached RM6.38 billion in 2019. This resulted in a large amount of waste produced annually. Utilizing these waste materials instead of letting them rot or deteriorate in the forests or at the factory yards sites could generate income and create job opportunities for the local community. A proper and systematic study needs to be undertaken in order to make them into reality.
A Modified Technique in Rhinoplasty: A Septal Extension Graft Complex Using Septal Cartilage, Ethmoid Bone, and Auricular Cartilage
Authors: Wang Jue , Li Binghang , Wang Qianwen , Wu Lehao , Zhang Chang , Zhao Sichun , Chen Lianjie , Li Kongying , Zhou Xu 
Published: July 2022

Abstract

Background
Due to the small and weak septal cartilage of Asians, it is a challenge to obtain ideal tip projection and nose lengthening in this population by performing septal extension grafts with only septal cartilage.

Objectives
The aim of this study was to introduce a septal extension graft complex incorporating nasal septal cartilage, the perpendicular plate of the ethmoid bone, and bilateral auricular cartilage, and to examine its effectiveness in terms of morphological and mechanical support.

Methods
Septal cartilage was harvested under an endoscope according to standard techniques. Two pieces of the perpendicular plate of the ethmoid bone, placed on either side of the “L” strut, served as 2 spreader grafts. A double layer of auricular cartilage was fixed as columellar strut grafts. Three-dimensional facial scanning was used to examine the change of 3 parameters. Nasal tip resistance was evaluated by a digital Newton meter.

Results
In total, 25 patients were followed up postoperatively for a mean of 25.9 months. The analysis showed significant differences in both contour parameters and nasal resistance: nasal length (mean [standard deviation], 41.4 [4.0] vs 46.2 [3.4] mm, P &lt; 0.05) and nasal tip projection (21.3 [3.2] vs 24.4 [2.7] mm, P &lt; 0.05) appeared to increase postoperatively, whereas nasolabial angle (117.6° [5.9°] vs 109.5° [5.3°], P &lt; 0.05) showed a significant decrease after surgery. The resistance of the nasal tip also increased significantly (P &lt; 0.05) at displacements of 1, 2, and 3 mm. All patients were satisfied with the aesthetic results, and no serious complications occurred.

Conclusions
This kind of modified septal extension graft technique can effectively adjust nasal morphology for short-nose East Asians.

Level of Evidence: 4
The Event of a Poem: Denise Riley’s ‘Lone Star Clattering’
Authors: Attridge Derek 
Published: July 2022

Abstract
If we think of a literary work as an event experienced by a reader or listener, and if one mode of literary criticism is an honest report on that event, a poem whose singularity lies in part in its resistance to the conventional protocols of interpretation, such as coherence and continuity, presents a particular challenge. In this short essay, I give an account of my reading of Denise Riley’s ‘Lone Star Clattering’ that attempts to reflect the obstacles it places in the way of such a critical mode, using, and testing, an approach developed to describe the operation of the traditional lyric poem, Don Paterson’s theory of ‘conceptual domains’.
Is This the Way to Amarillo? Reading Denise Riley with Derek Attridge
Authors: Wilkinson John 
Published: July 2022

Abstract
This essay responds to a challenge offered by the avowed bafflement of the critic and prosodist Derek Attridge faced with a poem by Denise Riley, ‘Lone Star Clattering’. It argues that Attridge’s adoption of an interpretative approach derived from Don Paterson, employing a step-by-step and constrictive cognitive framing, cannot succeed with a late Modernist lyric poem. Drawing on classroom experience with the same poem, it describes a prevalent cats-cradle approach as a variant on such constrictive reading, where a small group of external referents is grabbed onto, and the poem forced into unseemly conformity with them. The essay proposes instead a practice of feline reading characterized by a hovering casual interest, a constant scan of the sensual and mental fields so that their contours are felt, while sustaining a hair-trigger responsiveness to any unanticipated event along with a Keatsian tolerance of irresolution.
Reading the Event of the Poem: Derek Attridge and John Wilkinson on Denise Riley’s ‘Lone Star Clattering’
Authors: Nowell Smith David 
Published: July 2022

Abstract
In this brief introduction to Derek Attridge’s ‘The Event of a Poem’ and John Wilkinson’s ‘Reading Denise Riley with Derek Attridge’, David Nowell Smith outlines some of the key concepts and questions explored in Attridge’s and Wilkinson’s essays. The central question is a double one: How does meaning in a poem unfold, and how do we as readers make sense of this unfolding? To ask this question means focusing on meaning as a process rather than a content that lies notionally behind the words; it is to understand the poem as actualized in the event, and experience, of its encounter with its audience/reader. The introduction reflects on the peculiar challenges, and pleasures, posed by a poem, such as Denise Riley’s ‘Lone Star Clattering’, where the multiple registers, allusions, and references, would complicate our habitual meaning-making processes. What do individual reading histories bring to such a poem? And what kinds of attention would this poem demand of its readers?
Classification of Uniconnected Involutive Solutions of the Yang–Baxter Equation With Odd Size and a Z-Group Permutation Group
Authors: Castelli Marco 
Published: July 2022

Abstract
In the first part of this paper, we investigate the retraction of finite uniconnected involutive non-degenerate set-theoretic solutions of the Yang–Baxter equation by means of left braces, giving a precise description in some cases. In the core of the paper, we also use left braces to classify all the uniconnected involutive non-degenerate set-theoretic solutions having odd size and a Z-group permutation group. As an application, we classify all the uniconnected involutive non-degenerate solutions having odd square-free size.
Impact of Cover Crop Planting and Termination Dates on Arthropod Activity in the Following Corn
Authors: Inveninato Carmona Gabriela , Robinson Emily , Tonon Rosa Alexandre , Proctor Christopher A , McMechan Anthony Justin 
Published: July 2022

AbstractRelative to fallow-cash crop rotations, the addition of a cover crop can contribute to greater plant diversity and has the potential to conserve predatory arthropods. The transition of arthropods from a cover crop to a subsequent cash crop depends on several factors, such as cover crop biomass production and weather conditions. Information about the effect of cover crop planting and termination dates on arthropods in a subsequent corn system is limited. A two-year field study was conducted in Nebraska in 2018/2019 and 2019/2020 to evaluate the impact of cover crop planting and termination dates as a source for arthropods in the subsequent corn. A total of 38,074 and 50,626 arthropods were collected in the first and second year, respectively. In both years, adding a grass cover crop increased predatory arthropods but reduced yield in follow corn crop. Of the arthropods collected, Carabidae and Araneae had greater activity with cover crop biomass increments, whereas Collembola and Acari activity only increased in treatments with little or no cover crop biomass. Insect pest pressure was not significant in any treatment for either year. A cover crop planted in mid- or late-September and terminated at corn planting was identified as the best management strategy to maximize cover crop biomass, increase predator activity, and modify predator-prey dynamics. The results of this study provide growers with a cover crop management strategy to maximize cover crop biomass, beneficial arthropod activity, and potentially minimize insect pest problems; however, corn Zea Mays (L.) grain yield was reduced as cover crop biomass increased.
Spectrum of coronary anomalies and their categorical approach: rare case series
Authors: Bashyal Krishnaprasad , Koirala Bhagawan , Bhattarai Anil , Baral Ravi Kumar , Khakural Prabhat , Shakya Samir , Kadel Prashiddha Bikram 
Published: July 2022

Abstract
The incidence of coronary artery anomalies (CAAs) is 0.2–1.2% of the population. Its paradox of being a rare entity with presentation ranging from sudden cardiac death, congestive heart failure, myocardial infarction to being clinically silent, asserts a challenge to its treating physician. Among the various major categories of CAA, we describe four different types of these anomalies in our retrospective evaluation over 2 years. They include – coronary cameral fistula with coronary aneurysm, congenital atresia of left main, anomalous aortic origin of left anterior descending (LAD) and circumflex artery (LCx) with malignant LAD course, anomalous origin of left coronary artery from pulmonary artery (ALCAPA). Although the child with ALCAPA succumbed despite every possible and available timely efforts, other patients had good postoperative recovery and a brief hospital stay.
A Comprehensive Analysis of Injuries During Army Basic Military Training
Authors: Gibson Neil , Drain Jace R , Larsen Penelope , Michael Scott , Groeller Herbert , Sampson John A 
Published: July 2022

ABSTRACT

Introduction
The injury definitions and surveillance methods commonly used in Army basic military training (BMT) research may underestimate the extent of injury. This study therefore aims to obtain a comprehensive understanding of injuries sustained during BMT by employing recording methods to capture all physical complaints.

Materials and methods
Six hundred and forty-six recruits were assessed over the 12-week Australian Army BMT course. Throughout BMT injury, data were recorded via (1) physiotherapy reports following recruit consultation, (2) a member of the research team (third party) present at physical training sessions, and (3) recruit daily self-reports.

Results
Two hundred and thirty-five recruits had ≥1 incident injury recorded by physiotherapists, 365 recruits had ≥1 incident injury recorded by the third party, and 542 recruits reported ≥1 injury-related problems via the self-reported health questionnaire. Six hundred twenty-one, six hundred eighty-seven, and two thousand nine hundred sixty-four incident injuries were recorded from a total of 997 physiotherapy reports, 1,937 third-party reports, and 13,181 self-reported injury-related problems, respectively. The lower extremity was the most commonly injured general body region as indicated by all three recording methods. Overuse accounted for 79% and 76% of documented incident injuries from physiotherapists and the third party, respectively.

Conclusions
This study highlights that injury recording methods impact injury reporting during BMT. The present findings suggest that traditional injury surveillance methods, which rely on medical encounters, underestimate the injury profile during BMT. Considering accurate injury surveillance is fundamental in the sequence of injury prevention, implementing additional injury recording methods during BMT may thus improve injury surveillance and better inform training modifications and injury prevention programs.
A critical review of mineral–microbe interaction and co-evolution: mechanisms and applications
Authors: Dong Hailiang , Huang Liuqin , Zhao Linduo , Zeng Qiang , Liu Xiaolei , Sheng Yizhi , Shi Liang , Wu Geng , Jiang Hongchen , Li Fangru , Zhang Li , Guo Dongyi , Li Gaoyuan , Hou Weiguo , Chen Hongyu 
Published: July 2022

Abstract
Mineral–microbe interactions play important roles in environmental change, biogeochemical cycling of elements and formation of ore deposits. Minerals provide both beneficial (physical and chemical protection, nutrients, and energy) and detrimental (toxic substances and oxidative pressure) effects to microbes, resulting in mineral-specific microbial colonization. Microbes impact dissolution, transformation and precipitation of minerals through their activity, resulting in either genetically controlled or metabolism-induced biomineralization. Through these interactions, minerals and microbes co-evolve through Earth history. Mineral–microbe interactions typically occur at microscopic scale but the effect is often manifested at global scale. Despite advances achieved through decades of research, major questions remain. Four areas are identified for future research: integrating mineral and microbial ecology, establishing mineral biosignatures, linking laboratory mechanistic investigation to field observation, and manipulating mineral–microbe interactions for the benefit of humankind.
Evolutionary traits of Tick-borne encephalitis virus: Pervasive non-coding RNA structure conservation and molecular epidemiology
Authors: Kutschera Lena S , Wolfinger Michael T 
Published: July 2022

AbstractTick-borne encephalitis virus (TBEV) is the aetiological agent of tick-borne encephalitis, an infectious disease of the central nervous system that is often associated with severe sequelae in humans. While TBEV is typically classified into three subtypes, recent evidence suggests a more varied range of TBEV subtypes and lineages that differ substantially in the architecture of their 3ʹ untranslated region (3ʹUTR). Building on comparative genomic approaches and thermodynamic modelling, we characterize the TBEV UTR structureome diversity and propose a unified picture of pervasive non-coding RNA structure conservation. Moreover, we provide an updated phylogeny of TBEV, building on more than 220 publicly available complete genomes, and investigate the molecular epidemiology and phylodynamics with Nextstrain, a web-based visualization framework for real-time pathogen evolution.
Efficacy and Safety of PL-5 (Peceleganan) Spray for Wound Infections
Authors: Wei Yating , Wu Jun , Chen Yuxin , Fan Kunwu , Yu Xuming , Li Xiaojian , Zhao Yaohua , Li Yi , Lv Guozhong , Song Guodong , Rong Xinzhou , Lin Cai , Wang Haitao , Chen Xiaodong , Zhang Pihong , Han Chunmao , Zu Hongxu , Liu Wenjun , Zhang Yi , Liu Chang , Su Yongtao , Zhang Baolin , Sun Bingwei , Wang Lei , Lai Wen , Liu Jinhui , Xia Chengde , Ji Geng , Zhu Feng , Yu Jia’ao , Ahemaiti Akebaer , Dong Hu , Chen Mingxia ,   on behalf of the PL-5 Investigators
Published: July 2022

Objective:
To assess the safety and efficacy of antimicrobial peptide PL-5 (Peceleganan) spray in the treatment of wound infections.

Background:
Antimicrobial peptide PL-5 spray is a novel topical antimicrobial agent.

Methods:
We conducted a multicenter, open-label, randomized, controlled phase IIb clinical trial to evaluate the efficacy and safety of PL-5 spray, as compared with silver sulfadiazine, in patients with skin wound infections. The primary efficacy outcome was the clinical efficacy rate on the first day after ending the treatment (D8). The secondary efficacy outcome was the clinical efficacy rate on the fifth day posttreatment (D5), the bacteria clearance rate, and the overall efficacy rate at the mentioned 2 time points. The safety outcomes included adverse reactions and pharmacokinetic analysis posttreatment.

Results:
A total of 220 patients from 27 hospitals in China were randomly assigned to 4 groups. On D8, the efficacy rate was 100.0%, 96.7%, 96.7% for the 1‰ PL-5, 2‰ PL-5, 4‰ PL-5 groups, respectively, as compared with 87.5% for the control group. The efficacy rate among the 4 groups was significantly different (P<0.05). On D5, the efficacy rate was 100.0%, 93.4%, 98.3% for the 1‰ PL-5, 2‰ PL-5, 4‰ PL-5 groups, respectively, as compared with 82.5% for the control group. The efficacy rate among the 4 groups was significantly different (P<0.05). The blood concentration of PL-5 was not detectable in pharmacokinetic analysis. No severe adverse event related to the application of PL-5 was reported.

Conclusions:
Antimicrobial peptide PL-5 spray is safe and effective for the treatment of skin wound infections.

Trial Registration:
ChiCTR2000033334.
Digital approaches to continuing care
Authors: McKay James R. 
Published: July 2022

Purpose of review
To provide an update of studies on the effectiveness of digital and telephonic approaches to providing remote continuing care for substance use disorders.

Recent findings
Effective continuing care can be provided via smartphone apps, text messaging, interactive voice response, and structured telephone counseling. The remote continuing care interventions with the strongest evidence of efficacy are the Addiction Comprehensive Health Enhancement Support System app and Telephone Monitoring and Counseling. Positive effects for these intervention on drinking outcomes in patients with alcohol use disorders were replicated in a recent randomized controlled study.

Summary
Continuing care is widely believed to be an important component of treatment for substance use disorders, especially for sustaining positive outcomes. However, many individuals do not attend clinic-based continuing care, due to a variety of reasons, including competing work and family responsibilities, disabilities, transportation challenges, and recently the COVID-19 pandemic. Remote continuing care, provided via smartphone apps, text messaging, and various telephonic approaches, has been shown to be effective, and could be used to provide continuing care to patients who would otherwise not receive it. Further work is needed to determine how to effectively combine more traditional continuing care with newer digitized and telephonic approaches.