bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomimetic Natural Biopolymer‐Based Wet‐Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing
Authors: Yang Wen , Kang Xinyi , Gao Xu , Zhuang Yan , Fan Caixai , Shen He , Chen Yanyan , Dai Jianwu 
Published: December 2022

AbstractBioadhesives have been used in clinics among the most prospective alternatives to sutures and staples for wound sealing and repairing; however, they generally have inadequate adhesion to wet surfaces, improper mechanical strength, poor hemostasis, and cytotoxicity. To address these challenges, a robust wet tissue adhesive based on collagen and starch materials (CoSt) is designed in this study. CoSt hydrogels integrate the feature of drainage, molecular penetration and strengthen cross‐linking similar to mussel, ivy, and oyster glues, which remove interfacial water quickly, reinforce tough dissipation and involve multiple reversible dynamic interactions. Therefore, they form strong adhesion and sutureless sealing of injured tissues, accompanying actuate robust biointerfaces in direct contact with tissue liquids or blood, resolving the crucial impediments with sutures and commercially accessible adhesives. The novel bioadhesive shows repeatable strong wet tissue adhesiveness (62 ± 4.8 KPa), high sealing performance (153.2 ± 35.1 mmHg), fast self‐healing ability, excellent injectability, and shape adaptability. For different hemostatic needs in rat models of tail amputation, skin incision, severe liver, abdominal aorta, and transected nerve injuries, the CoSt hydrogel shows better hemostatic efficiency than fibrin glue because of the coordinate efficacy of tough wound sealing property, outstanding red blood cell arresting capability, and the activation of hemostatic barrier membrane. Moreover, in vivo investigation of the skin injury repair of the rat model validate that CoSt hydrogels accelerate wound healing and functional recovery via skin damage/defects. Tough wet adhesion, quick hemostasis, distinguished biocompatibility, suitability to match irregular‐shaped target sites, and good wound healing promotion of the CoSt hydrogel makes it a prospective bioadhesive for various biomedical applications.
Ni‐Alginate Hydrogel Microspheres with Sustained Interleukin 2 Release to Boost Cytokine‐Based Cancer Immunotherapy
Authors: Xiong Zijian , Sun Lele , Yang He , Xiao Zhisheng , Deng Zheng , Li Quguang , Wang Chenya , Shen Fengyun , Liu Zhuang 
Published: December 2022

AbstractInterleukin 2 (IL2) is the first approved immunotherapeutic agent in cancer treatment. However, high‐dose IL2 administrated through intratumoral injection still spreads all over the body, causing serious systemic toxicity. Herein, an injectable nickel‐alginate hydrogel microsphere (Ni‐ALGMS) to allow effective loading of IL2 and its sustained release after intratumoral administration is reported. In this design, histidine (his)‐tagged IL2 is assembled into the Ni‐ALGMS via the coordination bonds between his‐tag and Ni2+. After injecting IL2‐loaded Ni‐ALGMSs (IL2@Ni‐ALGMSs) into the tumor, IL2 slowly releases over long periods, thereby avoiding the risk of cytokine storm happening in IL2 systemic administration. Applying such IL2@Ni‐ALGMSs for tumor model treatment can significantly increase the tumor infiltration of T lymphocytes, and effectively inhibit tumor growth, especially in combination with immune checkpoint inhibitors. This study presents a novel IL2 sustained‐releasing platform for tumor immunotherapy, which can also be conveniently applied in other cytokines‐based immunotherapies.
A Versatile Nanoplatform Based on Metal‐Phenolic Networks Inhibiting Tumor Growth and Metastasis by Combined Starvation/Chemodynamic/Immunotherapy
Authors: Fu Zhaoming , Zhang Yufei , Chen Xiaolu , Wang Nan , Ma Rongying , Luo Xingyu , Pan Xin , Yang Yong , Xue Wei 
Published: December 2022

AbstractAlthough much progress has been made by multifunctional nanoplatforms in the treatment of cancer, several defects of existing nanoplatforms, such as tedious preparation, poor biocompatibility, and failure to activate the immune system, have limited their clinical applications. Herein, a versatile nanosystem of folic acid‐modified metal‐phenolic networks (MPNs) loaded with GOx and CHA (F‐MGC) is fabricated by the easy self‐assembly of MPNs, during which glucose oxidase (GOx) and chlorogenic acid (CHA) are concurrently loaded. The resulting nanosystem, having a folic acid‐modified surface and inherent acid sensitivity, shows versatility in being able to target tumors and release active ingredients in the weakly acidic tumor microenvironment (TME). Based on the catalysis of GOx and Fe3+, the cascade reaction aroused by F‐MGC efficiently consumes glucose in the TME and produces abundant cytotoxic hydroxyl radicals, thereby causing the starving and chemodynamic death of cancer cells. In addition, CHA can reshape M2 tumor‐associated macrophages (TAMs) into the M1 type, so as to change the immunosuppressive state of TME. The immunogenic cell death (ICD) that occurs from the starvation and chemodynamic therapy, in conjunction with the CHA‐induced TAMs polarization, further activates the immune system. Overall, the easily prepared nanoplatform has excellent biocompatibility and effectively inhibits tumor growth and metastasis.
A 3D Perfusable Platform for In Vitro Culture of Patient Derived Xenografts
Authors: Sablatura Lindsey K. , Bircsak Kristin M. , Shepherd Peter , Bathina Madhavi , Queiroz Karla , Farach‐Carson Mary C. , Kittles Rick A. , Constantinou Pamela E. , Saleh Anthony , Navone Nora M. , Harrington Daniel A. 
Published: December 2022

AbstractMany advanced cancer models, such as patient‐derived xenografts (PDXs), offer significant benefits in their preservation of the native tumor's heterogeneity and susceptibility to treatments, but face significant barriers to use in their reliance on a rodent host for propagation and screening. PDXs remain difficult to implement in vitro, particularly in configurations that enable both detailed cellular analysis and high‐throughput screening (HTS). Complex multilineage co‐cultures with stromal fibroblasts, endothelium, and other cellular and structural components of the tumor microenvironment (TME) further complicate ex vivo implementation. Herein, the culture of multiple prostate cancer (PCa)‐derived PDX models as 3D clusters within engineered biomimetic hydrogel matrices, in a HTS‐compatible multiwell microfluidic format, alongside bone marrow‐derived stromal cells and a perfused endothelial channel. Polymeric hydrogel matrices are customized for each cell type, enabling cell survival in vitro and facile imaging across all conditions. PCa PDXs demonstrate unique morphologies and reliance on TME partners, retention of known phenotype, and expected sensitivity or resistance to standard PCa therapeutics. This novel integration of technologies provides a fully human model, and expands the information to be gathered from each specimen, while avoiding the time and labor involved with animal‐based testing.
Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales
Authors: Schamberger Barbara , Ziege Ricardo , Anselme Karine , Ben Amar Martine , Bykowski Michał , Castro André P. G. , Cipitria Amaia , Coles Rhoslyn A. , Dimova Rumiana , Eder Michaela , Ehrig Sebastian , Escudero Luis M. , Evans Myfanwy E. , Fernandes Paulo R. , Fratzl Peter , Geris Liesbet , Gierlinger Notburga , Hannezo Edouard , Iglič Aleš , Kirkensgaard Jacob J. K. , Kollmannsberger Philip , Kowalewska Łucja , Kurniawan Nicholas A. , Papantoniou Ioannis , Pieuchot Laurent , Pires Tiago H. V. , Renner Lars D. , Sageman‐Furnas Andrew O. , Schröder‐Turk Gerd E. , Sengupta Anupam , Sharma Vikas R. , Tagua Antonio , Tomba Caterina , Trepat Xavier , Waters Sarah L. , Yeo Edwina F. , Roschger Andreas , Bidan Cécile M. , Dunlop John W. C. 
Published: December 2022

AbstractSurface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is supported by numerous experimental and theoretical investigations in recent years. In this review, first, a brief introduction to the key ideas of surface curvature in the context of biological systems is given and the challenges that arise when measuring surface curvature are discussed. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, the interplay between the distribution of morphogens or micro‐organisms and the emergence of curvature across length scales is addressed with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by‐product of the chemical, biological, and mechanical processes but that curvature acts also as a signal that co‐determines these processes.
Flash Recycling of Graphite Anodes
Authors: Chen Weiyin , Salvatierra Rodrigo V. , Li John Tianci , Kittrell Carter , Beckham Jacob L. , Wyss Kevin M. , La Nghi , Savas Paul E. , Ge Chang , Advincula Paul A. , Scotland Phelecia , Eddy Lucas , Deng Bing , Yuan Zhe , Tour James M. 
Published: December 2022

AbstractThe ever‐increasing production of commercial lithium‐ion batteries (LIBs) will result in a staggering accumulation of waste when they reach their end of life. A closed‐loop solution, with effective recycling of spent LIBs, will lessen both the environmental impacts and economic cost of their use. Presently, <5% of spent LIBs are recycled and the regeneration of graphite anodes has, unfortunately, been mostly overlooked despite the considerable cost of battery‐grade graphite. Here, an ultrafast flash recycling method to regenerate the graphite anode is developed and valuable battery metal resources are recovered. Selective Joule heating is applied for only seconds to efficiently decompose the resistive impurities. The generated inorganic salts, including lithium, cobalt, nickel, and manganese, can be easily recollected from the flashed anode waste using diluted acid, specifically 0.1 m HCl. The flash‐recycled anode preserves the graphite structure and is coated with a solid‐electrolyte‐interphase‐derived carbon shell, contributing to high initial specific capacity, superior rate performance, and cycling stability, when compared to anode materials recycled using a high‐temperature‐calcination method. Life‐cycle‐analysis relative to current graphite production and recycling methods indicate that flash recycling can significantly reduce the total energy consumption and greenhouse gas emission while turning anode recycling into an economically advantageous process.
Tuning Surface Acidity of Mixed Conducting Electrodes: Recovery of Si‐Induced Degradation of Oxygen Exchange Rate and Area Specific Resistance
Authors: Seo Han Gil , Staerz Anna , Kim Dennis S. , LeBeau James M. , Tuller Harry L. 
Published: December 2022

AbstractMetal oxides are an important class of functional materials, and for many applications, ranging from solid oxide fuel/electrolysis cells, oxygen permeation membranes, and oxygen storage materials to gas sensors (semiconducting and electrolytic) and catalysts, the interaction between the surface and oxygen in the gas phase is central. Ubiquitous Si‐impurities are known to impede this interaction, commonly attributed to the formation of glassy blocking layers on the surface. Here, the surface oxygen exchange coefficient (kchem) is examined for Pr0.1Ce0.9O2‐δ (PCO), a model mixed ionic electronic conductor, via electrical conductivity relaxation measurements, and the area‐specific resistance (ASR) by electrochemical impedance spectroscopy. It is demonstrated that even low silica levels, introduced by infiltration, depress kchem by a factor 4000, while the ASR increases 40‐fold and we attribute this to its acidity relative to that of PCO. The ability to fully regenerate the poisoned surface by the subsequent addition of basic Ca‐ or Li‐species is further shown. This ability to not only recover Si‐poisoned surfaces by tuning the relative surface acidity of an oxide surface, but subsequently outperform the pre‐poisoned response, promises to extend the operating life of materials and devices for which the catalytic oxygen/solid interface reaction is central.
Transition Metal Ion Doping on ZIF‐8 Enhances the Electrochemical CO2 Reduction Reaction
Authors: Cho Jin Hyuk , Lee Chaehyeon , Hong Sung Hyun , Jang Ho Yeon , Back Seoin , Seo Myung‐gi , Lee Minzae , Min Hyung‐Ki , Choi Youngheon , Jang Youn Jeong , Ahn Sang Hyun , Jang Ho Won , Kim Soo Young 
Published: December 2022

AbstractThe electrochemical reduction of CO2 to diverse value‐added chemicals is a unique, environmentally friendly approach for curbing greenhouse gas emissions while addressing sluggish catalytic activity and low Faradaic efficiency (FE) of electrocatalysts. Here, zeolite‐imidazolate‐frameworks‐8 (ZIF‐8) containing various transition metal ions—Ni, Fe, and Cu—at varying concentrations upon doping are fabricated for the electrocatalytic CO2 reduction reaction (CO2RR) to carbon monoxide (CO) without further processing. Atom coordination environments and theoretical electrocatalytic performance are scrutinized via X‐ray absorption spectroscopy (XAS) and density functional theory (DFT) calculations. Upon optimized Cu doping on ZIF‐8, Cu0.5Zn0.5/ZIF‐8 achieves a high partial current density of 11.57 mA cm–2 and maximum FE for CO of 88.5% at –1.0 V (versus RHE) with a stable catalytic activity over 6 h. Furthermore, the electron‐rich sp2 C atom facilitates COOH* promotion after Cu doping of ZIF‐8, leading to a local effect between the zinc–nitrogen (Zn–N4) and copper–nitrogen (Cu–N4) moieties. Additionally, the advanced CO2RR pathway is illustrated from various perspectives, including the pre‐H‐covered state under the CO2RR. The findings expand the pool of efficient metal–organic framework (MOF)‐based CO2RR catalysts, deeming them viable alternatives to conventional catalysts.
Ferroelectric Domain Control of Nonlinear Light Polarization in MoS2 via PbZr0.2Ti0.8O3 Thin Films and Free‐Standing Membranes
Authors: Li Dawei , Huang Xi , Wu Qiuchen , Zhang Le , Lu Yongfeng , Hong Xia 
Published: December 2022

AbstractTwo‐dimensional (2D) transition metal dichalcogenides (TMDCs) such as MoS2 exhibit exceptionally strong nonlinear optical responses, while nanoscale control of the amplitude, polar orientation, and phase of the nonlinear light in TMDCs remains challenging. In this work, by interfacing monolayer MoS2 with epitaxial PbZr0.2Ti0.8O3 (PZT) thin films and free‐standing PZT membranes, the amplitude and polarization of the second harmonic generation (SHG) signal are modulated via ferroelectric domain patterning, which demonstrates that PZT membranes can lead to in‐operando programming of nonlinear light polarization. The interfacial coupling of the MoS2 polar axis with either the out‐of‐plane polar domains of PZT or the in‐plane polarization of domain walls tailors the SHG light polarization into different patterns with distinct symmetries, which are modeled via nonlinear electromagnetic theory. This study provides a new material platform that enables reconfigurable design of light polarization at the nanoscale, paving the path for developing novel optical information processing, smart light modulators, and integrated photonic circuits.
Highly Sensitive and Cost‐Effective Polymeric‐Sulfur‐Based Mid‐Wavelength Infrared Linear Polarizers with Tailored Fabry–Pérot Resonance
Authors: Cho Woongbi , Hwang Jehwan , Lee Sang Yeon , Park Jaeseo , Han Nara , Lee Chi Hwan , Kang Sang‐Woo , Urbas Augustine , Kim Jun Oh , Ku Zahyun , Wie Jeong Jae 
Published: December 2022

AbstractInverse‐vulcanized polymeric sulfur has received considerable attention for application in waste‐based infrared (IR) polarizers with high polarization sensitivities, owing to its high transmittance in the IR region and thermal processability. However, there have been few reports on highly sensitive polymeric sulfur‐based polarizers by replication of pre‐simulated dimensions to achieve a high transmission of the transverse magnetic field (TTM) and extinction ratio (ER). Herein, a 400‐nanometer‐pitch mid‐wavelength infrared bilayer linear polarizer with self‐aligned metal gratings is introduced on polymeric sulfur gratings integrated with a spacer layer (SM‐polarizer). The dimensions of the SM‐polarizer can be closely replicated using pre‐simulated dimensions via a systematic investigation of thermal nanoimprinting conditions. Spacer thickness is tailored from 40 to 5100 nm by adjusting the concentration of polymeric sulfur solution during spin‐coating. A tailored spacer thickness can maximize TTM in the broadband MWIR region by satisfying Fabry–Pérot resonance. The SM‐polarizer yields TTM of 0.65, 0.59, and 0.43 and ER of 3.12 × 103, 5.19 × 103, and 5.81 × 103 at 4 µm for spacer thicknesses of 90, 338, and 572 nm, respectively. This demonstration of a highly sensitive and cost‐effective SM‐polarizer opens up exciting avenues for infrared polarimetric imaging and for applications in polarization manipulation.
Tube‐Sponge‐Inspired Hierarchical Electrocatalysts with Boosted Mass and Electron Transfer for Efficient Oxygen Evolution
Authors: Zhou Yaya , Jin Ningxuan , Ma Yibing , Cui Yushuang , Wang Lina , Kwon Yongwoo , Lee Won‐Kyu , Zhang Wei , Ge Haixiong , Zhang Jian 
Published: December 2022

AbstractHindered gas bubble release and limited electron conducting process represent the major bottlenecks for large‐scale electrochemical water splitting. Both the desorption of bubbles and continuous electron transport are achievable on the surfaces of biomimetic catalytic materials by designing multiscale structural hierarchy. Inspired by the tubular structures of the deep‐sea sponges, an exceptionally active and binder‐free porous nickel tube arrays (PNTA) decorated with NiFe‐Zn2+‐pore nanosheets (NiFe‐PZn) are fabricated. The PNTA facilitate removal of bubbles and electron transfer in the oxygen evolution reaction by reproducing trunks of the sponges, and simultaneously, the NiFe‐PZn increase the number of catalytic active sites by simulating the sponge epidermis. With improved external mass transfer and interior electron transfer, the hierarchical NiFe‐PZn@PNTA electrode exhibits superior oxygen evolution reaction performance with an overpotential of 172 mV at 10 mA cm−2 (with a Tafel slope of 50 mV dec−1). Furthermore, this electrocatalytic system recorded excellent reaction stability over 360 h with a constant current density of 100 mA cm−2 at the potential of 1.52 V (versus RHE). This work provides a new strategy of designing hierarchical electrocatalysts for highly efficient water splitting.
Z‐Scheme Strategy in Polymeric Graphitic C3N5/CdS Core–Shell Heterojunction Drives Long‐Lived Carriers Separation for Robust Visible‐Light Hydrogen Production
Authors: Wang Xin , Wu Kaili , Cao Wei , Rui Kun , Wang Wenchao , Zhu Ruixue , Zhu Jixin , Yan Zhiping 
Published: December 2022

AbstractThe intrinsic charge carriers’ recombination and excited states decay greatly suppress the active species survival and photo(electro)catalytic performance. Inspired by Z‐scheme strategy, the polymeric nitrogen‐rich carbon nitride/cadmium sulfide (g‐C3N5/CdS) core–shell heterojunction is constructed to optimize photocatalytic performance. The optimal hydrogen production rate of g‐C3N5/CdS heterojunction catalyst under visible light without adding extra cocatalyst is up to 7860 µmol h−1 g−1, which is 3 and 71 times higher than that of pure CdS and g‐C3N5 photocatalysts, respectively. The femtosecond transient absorption spectroscopy is employed to observe the kinetic decay of carriers in the heterojunction, revealing the ultrafast charge trapping process (τ1 = 52.3 ps) and long‐lived excited states (τ3 = 1109.2 ps) in g‐C3N5/CdS photocatalyst. Meanwhile, density functional theory calculation results comprehensively suggest the promoted charge separation in heterojunction. Cost‐effective Z‐scheme g‐C3N5/CdS photocatalyst in this work shows a great potential for sustainable and high‐efficiency solar‐to‐H2 conversion.
The Growth of Metal–Organic Framework Films on Calcium Fluoride and Their Interaction With Reactive Molecules
Authors: Mandemaker Laurens D. B. , Jabbour Christia , Nikolopoulos Nikolaos , Dorresteijn Joren M. , Rivera‐Torrente Miguel , Weckhuysen Bert M. 
Published: December 2022

AbstractSpectroscopy on metal–organic framework (MOF) films and the molecular phenomena associated to them is mostly limited to grazing incidence methods. To allow for transmission‐based characterization and highlight the applicability of MOFs on transparent substrates, UiO‐67, UU‐1, and ZIF‐8 MOFs are synthesized on CaF2 windows. It is revealed that the growth of the UiO‐67 MOF follows a Volmer–Weber mechanism using scanning electron microscopy (SEM). This growth is assisted by growing seeds in solution, which anchor on the film and become part of the intergrown film itself. UU‐1, a copper‐based MOF, is formed after spin coating the Cu‐BTC precursors, showing its characteristic fiber‐like morphology and resulting inter‐fiber macroporosity. ZIF‐8 is formed using a “flash”‐synthesis, and it is shown that this approach resembles a Volmer–Weber growth mode as well. Last, CO probe molecule adsorption FT‐IR spectroscopy is utilized to study the effect of methanol exposure. UiO‐67 becomes inaccessible toward CO, due to the formation of methoxy species, whereas UU‐1 undergoes a topotactic transformation to HKUST‐1. ZIF‐8 is the most stable as methanol only removes impurities from the framework. This approach opens the venue for other film materials to be studied in situ synthesis, sorption, or catalysis using transmission‐based spectroscopy.
Controlling the Surface Modification by CF4 Plasma Treatment for Inkjet Printed Color Conversion Layer With InP‐Based QDs Ink
Authors: Lee Sang Youn , Sakong Chun , Choi Sung‐Hwan , Ju Byeong‐Kwon , Cho Kwan Hyun 
Published: December 2022

AbstractControlling of thickness profile in micro‐scale pixels via an inkjet printing process remains a challenge and strict control of surface energy is required. Herein, the surface energy of each substrate is controlled by using CF4 plasma treatment (CPT) to control thickness profile and improve color conversion efficiency (CCE) of the inkjet printed quantum dots (QDs) color conversion layer (CCL). The bank surface becomes hydrophobic due to the fluorination, while the glass becomes hydrophilic due to the cleaning effect by the CPT. Through a systemic investigation of the polar and non‐polar components of the surface energy, it is found that the ink behavior of inkjet‐printed QDs in the pixels is closely related to the non‐polar component of the surface energy. In addition, it is found that more rigorous control of the surface is required for array printing and a wide range of thickness profile control is possible by CPT. The thickness increases by up to 10 µm, the blue leakage is reduced by 26.38%, and the CCE increases by a maximum of 5.71% depending on the CPT. As a result, the relationship between the thickness profile of the CCL and CCE is confirmed through the fabrication of QD‐organic light emitting diodes.