bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Manajemen Produksi dan Penjualan Produk Banyu Lemon (Sari Lemon) Dengan Memanfaatkan Website Dan Marketplace Di Masa Pandemi Covid-19
Authors: Susena Edy , Sukendar Markus , Setiyanto Riyan , Primadani Afrilia , Maris Yogi , Pangastuti Dewi 
Published: November 2022

Pandemi covid-19 yang melanda dunia pada dua tahun terakhir ini telah menyebabkan terpuruknya berbagai sektor, salah satunya sektor ekonomi. Banyak perusahaan besar sampai industri rumah tangga tidak dapat beroperasi. Di masa new normal ini pelan – pelan sektor ekonomi mulai bangkit. Kebangkitan sektor ekonomi tentunya perlu dukungan dari berbagai pihak.
Tim Penerapan Ipteks Masyarakat Politeknik Indonusa Surakarta bekerja sama dengan Direktorat Jenderal Pendidikan Vokasi memberikan dukungan kepada industri rumahan Banyu Lemon Ngargoyoso Karanganyar untuk bangkit lagi. Program yang diberikan adalah Penerapan Ipteks Masyarakat (PIM)
Program Penerapan Ipteks Masyarakat (PIM) yang dilaksanakan di Industri Rumahan Banyu Lemon Ngargoyoso Karanganyar selama 6 bulan mulai bulan Juli-Desember 2022. Kegiatan yang dilakukan adalah Forum Group Disscusion dengan mitra, memproses Izin PIRT ke Dinas Kesehatan Kabupaten Karanganyar, merancang sistem informasi penjualan secara online, mendaftarkan produk Banyu Lemon ke marketplace, membuat varian produk Lemon Madu, mendesain label dan kemasan produk, meningkatkan produktifitas, meningkatkan jumlah agen pemasaran.
Kata kunci: Banyu, Lemon, Sari, online
Terapan Iptek Kewirausahaan Untuk Hasil Produk Pengelasan Kepada Masyarakat Kayang Makmur, Kabupaten Madiun
Authors: Mohammad Erik Echsony  , Muhammad Taali  , Alfi Tranggono Agus Salim  , Ina Syarifah  , Rahayu Mekar Bisono  , Khandia Nabil Khoyyiroh  , Rafli Maulana  , Imerlipta Sekar Artianingrum  , Rachel Yogi Iswari  
Published: November 2022

Tingkat kemampuan berwirausaha dibidang pengelasan yang dimiliki masyarakat Dusun Kayang Makmur, Desa Bader, Kecamatan Dolopo, Kabupaten Madiun dinilai rendah karena keterbatasan materi, hal ini berdampak pada perawatan dan perbaikan dalam bentuk pengelasan untuk alat pertanian dari baja yang sebagian besar digunakan oleh masyarakat Dusun Kayang Makmur. Oleh karena itu, diadakannya pelatihan pengelasan dan kewirausahaan yang kemudian hari dikembangkan menjadi suatu ide usaha. Dengan penguasaan keterampilan pengelasan maka produk yang dihasilkan masyarakat desa mampu dijadikan kegiatan berwirausaha dan bersaing pada pasar di era globalisasi. Penyelenggaraan kegiatan program kemitraan masyarakat ini dilaksanakan dengan beberapa parameter yang dapat dicapai luaran dari kegiatan ini berupa kemampuan kewirausahaan yang bermanfaat bagi masyarakat Dusun Kayang Makmur. Tahapan pelaksanaan terdiri dari teori dasar kewirausahaan dan praktek pemasaran produk yang telah dibuat. Hasil dari pengabdian (pelatihan) kewirausahaan berupa pengetahuan dalam hal dasar kewirausahaan dan penerapannya.
Airway management with novel intubating laryngeal tubes has no influence on cerebral oxygenation in cardiac surgery patients: A prospective observational study
Authors: Kriege Marc , Rissel René , Heid Florian , Ott Thomas , Beyrouti Hazem El , Hotz Eric 
Published: November 2022

BackgroundA laryngeal tube is often used as an alternative to intubation with direct laryngoscopy during cardiopulmonary resuscitation. However, in a study with piglets undergoing simulated cardiac arrest, reduced carotid artery blood flow was associated with the insertion of different supraglottic airway devices, such as a laryngeal tube. Limited by its construction, secondary tracheal intubation through a laryngeal tube was difficult or impossible in contrast to a second generation laryngeal mask. The new disposable intubating laryngeal tube with suction (iLTS-D®) seems to facilitate tracheal intubation. We hypothesized that iLTS-D, when inflated to the recommended air volume, does not reduce cerebral oxygenation in patients with cardiovascular diseases undergoing elective cardiac surgery.MethodsThis single-center prospective, controlled observational study was approved by the local ethics committee (Ethical Committee No. 2018-13716). Forty adult patients undergoing elective cardiac surgery requiring tracheal intubation were included in this study. The exclusion criteria were age &lt;18 years and a high risk of aspiration, inability to consent, height &lt;155 cm, or pregnancy. Prior to insufflation and deflation of the cuffs, we performed cerebral oximetry via near-infrared spectroscopy. The primary outcome was a significant reduction in NIRS in the context of the preinduction baseline value after inflation of the cuffs with the recommended air volume, defined as a ≥25% decrease from baseline or an absolute value ≤ 50%. The secondary endpoints were differences in time points, insertion success rates, and complications.ResultsThere was no significant reduction in cerebral oximetry after inflation with the recommended cuff volume and an initially measured cuff pressure of &gt;120 cmH2O. Overall, tracheal intubation was achieved in a median of 20 s [interquartile range 15-23 s] and enabled sufficient ventilation and tracheal intubation through the iLTS-D in all patients. Traces of blood on the cuffs (after removing the iLTS-D) and a sore throat (evaluated 2 h after removing the tracheal tube) were observed in one patient.ConclusionOur results showed no association between the insertion of the iLTS-D and reduced cerebral oxygenation in patients undergoing elective cardiac surgery.Trial registrationClinicalTrials.gov, NCT03942809.
Cardiovascular autonomic modulation differences between moderate-intensity continuous and high-intensity interval aerobic training in women with PCOS: A randomized trial
Authors: Philbois Stella V. , Ribeiro Victor B. , Tank Jens , Reis Rosana Maria dos , Gerlach Darius A. , Souza Hugo C. D. 
Published: November 2022

BackgroundModerate-intensity continuous training (MICT) is strongly recommended for polycystic ovarian syndrome (PCOS) treatment. However, recent studies have suggested that high-intensity interval training (HIIT) would promote great benefits for cardiac autonomic control. Therefore, we investigated whether the benefits of HIIT related to cardiovascular autonomic control were greater than those of MICT in women with PCOS.MethodsWomen with PCOS were randomly allocated through a blind draw into three groups: control, MICT, and HIIT. The control group did not undergo exercise, whereas those in the MICT and HIIT groups underwent 16 weeks of aerobic physical training. All groups were evaluated before and after the 16 weeks of intervention in the following aspects: quantification of serum lipids, testosterone, fasting insulin and blood glucose; physical fitness through cardiopulmonary testing; analysis of heart rate variability (HRV) by linear (time domain and frequency domain) and non-linear (symbolic analysis) methods, analysis of blood pressure variability (BPV) and spontaneous baroreflex sensitivity (BRS).ResultsThe final analysis, each group comprised 25 individuals. All groups had similar baseline parameters. After 16 weeks, intragroup comparison showed that the MICT and HIIT groups had a reduction in baseline heart rate (P &lt; 0.001; P &lt; 0.001, respectively) and testosterone levels P &lt; 0.037; P &lt; 0.012, respectively) associated with an increase in VO2peak (MICT, P &lt; 0.001; HIIT, P &lt; 0.001). The MICT (P &lt; 0.36) and HIIT (P &lt; 0.17) groups also showed an increase in cardiac vagal modulation, however only observed in the non-linear analysis. The intergroup comparison showed no differences between the MICT and HIIT groups in any of the hormonal, metabolic and autonomic parameters evaluated, including testosterone, peak oxygen uptake (VO2peak), HRV, BPV and BRS.ConclusionHIIT and MICT showed similar results for the different parameters evaluated. This suggests that both training protocols can be recommended for the treatment of PCOS. Brazilian Clinical Trials Registry (RBR-78qtwy).
Health-related quality of life in boys with constitutional delay of growth and puberty
Authors: Kariola Laura , Varimo Tero , Huopio Hanna , Tenhola Sirpa , Voutilainen Raimo , Kosola Silja , Toppari Jorma , Sintonen Harri , Miettinen Päivi J. , Raivio Taneli , Hero Matti 
Published: November 2022

IntroductionConstitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy male adolescents. The main indication for medical treatment for this condition is psychosocial burden. However, to the best of our knowledge, no previous study has addressed the impact of puberty-promoting treatment on health-related quality of life (HRQoL) among boys with CDGP.MethodsWe investigated HRQoL in 22 boys with CDGP, who participated in a randomized controlled trial in four Finnish pediatric endocrinology outpatient clinics between 2013 and 2017. The boys were randomized to receive either aromatase inhibitor letrozole (2.5mg/day; n=11) or intramuscular testosterone (1mg/kg/every 4 weeks; n=11) for 6 months and followed up to 12 months. HRQoL was assessed with a generic self-assessment 16D© instrument developed and validated for adolescents aged 12 to 15 years. The 16D includes 16 dimensions (vitality, sight, breathing, distress, hearing, sleeping, eating, discomfort and symptoms, speech, physical appearance, school and hobbies, mobility, friends, mental function, excretion and depression). The results were compared with an age-matched reference population that included 163 boys from the Finnish capital-city area. The study protocol is registered to ClinicalTrials.gov (registration number: NCT01797718).ResultsAt baseline, the mean 16D score of the CDGP boys was similar to the age-matched reference population (0.95 vs 0.96, p=0.838). However, the physical appearance score (satisfaction with general appearance, height and weight) was significantly lower in the CDGP boys (0.75 vs 0.92, p=0.004) than their peers. Twelve months after treatment, Appearance had improved significantly (0.75 vs 0.87, p=0.004) and no HRQoL dimension was inferior compared to the age-matched reference population.DiscussionIn terms of HRQoL, the main impact of delayed puberty was dissatisfaction with physical appearance. Puberty promoting therapy was associated with a positive change in perceived appearance, with no clear difference between low-dose testosterone and letrozole treatments.
Simultaneous measurement of multiple variant-specific SARS-CoV-2 neutralizing antibodies with a multiplexed flow cytometric assay
Authors: Liu Hong , Varvel Stephen , Chen Ge , McConnell Joseph , Caffrey Rebecca , Galdzicka Marzena , Shabahang Shahrokh 
Published: November 2022

IntroductionNeutralizing antibodies (NAbs) have been recognized as surrogates of protection against SARS-CoV-2; however, the emergence of variants/subvariants escaping neutralization suggests that laboratory assessments of NAbs against the ancestral/wild type (WT) antigens likely overestimate the degree of protection.MethodsA novel flow cytometry-based multiplex test system was developed for the simultaneous detection of NAbs of multiple SARS-CoV-2 variants. SARS-CoV-2 antibodies (Abs) including IgG, IgM, IgA isotypes were measured in the same system. Samples from negative, convalesced, vaccinated, boosted, and breakthrough infection (BTI) populations were tested for both NAbs and Abs.ResultsNAbs induced by WT showed neutralization activity that correlated strongly to all variants (R2 &gt; 0.85) except omicron BA.1/BA.2 (R2 &lt;0.50). Two doses of vaccine elicited very little protective immunity against BA.1/BA.2, though a booster dose significantly improved NAbs for all variants. NAbs/Abs increased more following BTI than after a booster, suggesting that hybrid immunity (vaccination + natural immunity) was more robust to all variants including BA.1/BA.2. BTIs occurring in the omicron era led to stronger NAb responses against BA.1/BA.2 than did older BTIs. In all comparisons, the RBD antigens demonstrated greater differences between WT and BA.1/BA.2 than the spike antigens.DiscussionTaken together, we demonstrated that both Ab and NAb against multiple SARS-CoV-2 variants/subvariants can be reliably detected on the same multiplex platform. Distinguishing NAbs to the appropriate antigenic target of prevalent variants offers the best correlate of protection and aids individual decisions about the appropriateness and cadence of vaccine boosters and other exposure mitigation strategies.
Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer
Authors: Fang Kun , Xu Zhengjie , Jiang Suxiao , Yan Changsheng , Tang Desheng , Huang Yan 
Published: November 2022

ObjectiveFerroptosis is an iron-dependent type of regulated cell death triggered by the toxic buildup of lipid peroxides on cell membranes. Nonetheless, the implication of ferroptosis in triple‐negative breast cancer (TNBC), which is the most aggressive subtype of breast carcinoma, remains unexplored.MethodsThree TNBC cohorts—TCGA-TNBC, GSE58812, and METABRIC—were adopted. Consensus molecular subtyping on prognostic ferroptosis-related genes was implemented across TNBC. Ferroptosis classification-relevant genes were selected through weighted co-expression network analysis (WGCNA), and a ferroptosis-relevant scoring system was proposed through the LASSO approach. Prognostic and immunological traits, transcriptional and post-transcriptional modulation, therapeutic response, and prediction of potential small-molecule agents were conducted.ResultsThree disparate ferroptosis patterns were identified across TNBC, with prognostic and immunological traits in each pattern. The ferroptosis-relevant scoring system was proposed, with poorer overall survival in high-risk patients. This risk score was strongly linked to transcriptional and post-transcriptional mechanisms. The high-risk group had a higher response to anti-PD-1 blockade or sunitinib, and the low-risk group had higher sensitivity to cisplatin. High relationships of risk score with immunological features were observed across pan-cancer. Two Cancer Therapeutics Response Portal (CTRP)-derived agents (SNX-2112 and brefeldin A) and PRISM-derived agents (MEK162, PD-0325901, PD-318088, Ro-4987655, and SAR131675) were predicted, which were intended for high-risk patients.ConclusionAltogether, our findings unveil prognostic, immunological, and pharmacogenomic features of ferroptosis in TNBC, highlighting the potential clinical utility of ferroptosis in TNBC therapy.
A novel approach for fibrous dysplasia assessment using combined planar and quantitative SPECT/CT analysis of Tc-99m-diphosphonate bone scan in correlation with biological bone turnover markers of disease activity
Authors: Jreige Mario , Hall Nicolas , Becce Fabio , Aubry-Rozier Bérengère , Gonzalez Rodriguez Elena , Schaefer Niklaus , Prior John O. , Nicod Lalonde Marie 
Published: November 2022

PurposeTo investigate the emerging role of Tc-99m-labeled diphosphonate (Tc-99m-DPD) uptake quantification by SPECT/CT in fibrous dysplasia (FD) bone lesions and its correlation with biological bone turnover markers (BTMs) of disease activity.Materials and methodsSeven patients (49 ± 16 years) with a confirmed diagnosis of FD were included in this retrospective study. Bone scans with Tc-99m-DPD and quantitative SPECT/CT (xSPECT/CT) were performed. SUVmax (maximum standard unit value) and SUVmean (mean standard unit value) were measured in all FD bone lesions. The skeletal burden score (SBS) was assessed on planar scintigraphy and multiplied by mean SUVmax and SUVmean to generate two new parameters, SBS_SUVmax and SBS_SUVmean, respectively. Planar and xSPECT/CT quantitative measures were correlated with biological BTMs of disease activity, including fibroblast growth factor 23 (FGF-23), alkaline phosphatase (ALP), procollagen 1 intact N-terminal propeptide (P1NP) and C-terminal telopeptide (CTX), as well as scoliosis angle measured on radiographs. Statistical significance was evaluated with Spearman’s correlations.ResultsA total of 76 FD bone lesions were analyzed, showing an average SUVmax and SUVmean (g/mL) of 13 ± 7.3 and 8 ± 4.5, respectively. SBS, SBS_SUVmax and SBS_SUVmean values were 30.8 ± 25.6, 358 ± 267 and 220.1 ± 164.5, respectively. Mean measured values of FGF-23 (pg/mL), ALP (U/L), P1NP (μg/L) and CTX (pg/mL) were 98.4 (22–175), 283.5 (46–735), 283.1 (31–1,161) and 494 (360–609), respectively. Mean scoliosis angle was 15.7 (7–22) degrees. We found a very strong positive correlation between planar-derived SBS and CTX (r = 0.96, p = 0.010), but no significant correlation between SUVmax or SUVmean and biological BTMs. SBS_SUVmax showed a strong to very strong positive correlation with CTX (ρ = 0.99, p = 0.002), FGF-23 (ρ = 0.91, p = 0.010), ALP (ρ = 0.82, p = 0.020), and P1NP (ρ = 0.78, p = 0.039), respectively.ConclusionThis study showed that biological BTMs are significantly correlated with diphosphonate uptake on bone scan, quantified by a new parameter combining information from both planar and quantitative SPECT/CT. Further analysis of bone scan quantitative SPECT/CT data in a larger patient population might help better characterize the skeletal disease burden in FD, and guide treatment and follow-up.
Evaluation of the use of video consultation in German rheumatology care before and during the COVID-19 pandemic
Authors: Richter Jutta G. , Chehab Gamal , Reiter Joana , Aries Peer , Muehlensiepen Felix , Welcker Martin , Acar Hasan , Voormann Anna , Schneider Matthias , Specker Christof 
Published: November 2022

BackgroundThe COVID-19 pandemic led to transformations in healthcare infrastructures and increased use of (innovative) telemedicine (TM) tools. Comparison of the use of video consultation (VC) in rheumatology in the pre-pandemic period and during the pandemic might allow for evaluating this new form of consultancy in healthcare due to changing conditions and possibilities.Materials and methodsCross-sectional nationwide online survey among German rheumatologists and rheumatologists in training between March and May 2021 promoted by newsletters and Twitter posts.ResultsResults refer to 205 participants. The majority was male (59%), older than 40 years (90%). Thirty-eight percent stated to have employed TM before (“digital users”), 27% were using VC as part of their TM expertise (“VC-users”), 10% stated to have experience with TM but not VC (“TM-users”). Those negating the use of any TM (62%) were designated as “digital non-users.” TM-Knowledge was self-rated as 4 [median on a Likert Scale 1 (very high) to 6 (very low)] with a significant difference between digital users (VC-user 2.7 ± 1.2, TM-user 3.2 ± 1.1) and digital non-users (4.4 ± 1.3). The reported significant increase of VC use during the lockdown periods and between the lockdowns compared to the pre-pandemic phase was regarded as a proxy for VC acceptance in the pandemic. Reasons for VC non-use were administrative/technical efforts (21%), lack of technical equipment (15%), time constraints (12%), time required for individual VC sessions (12%), inadequate reimbursement (11%), lack of demand from patients (11%), data security concerns (9%), poor internet connection (8%), and lack of scientific evaluation/evidence (5%). Physicians considered the following clinical situations to be particularly suitable for VC: follow-up visits (VC-user 79%, TM-user 62%, digital non-user 47%), emergency consultations (VC-user 20%, TM-user 33%, digital non-user 20%), and patients presenting for the first time (VC-user 11%, TM-user 19%, digital non-user 8%).ConclusionEven though the pandemic situation, with social distancing and several lockdowns, provides an ideal environment for the implementation of new remote care forms as VC, its use and acceptance remained comparatively low due to multiple reasons. This analysis may help identify hurdles in employing innovative digital care models for rheumatologic healthcare.
Predictors of use of direct oral anticoagulants in patients with venous thromboembolism: Findings from the Registro Informatizado Enfermedad Tromboembólica registry
Authors: Lorenzo Alicia , Beroiz Patricia , Ortiz Salvador , del Toro Jorge , Mazzolai Lucia , Bura-Riviere Alessandra , Visonà Adriana , Verhamme Peter , Di Micco Pierpaolo , Camporese Giuseppe , Sancho Bueso Teresa , Monreal Manuel ,   the RIETE Investigators
Published: November 2022

BackgroundCurrent guidelines recommend the use of direct oral anticoagulants (DOACs) for patients with venous thromboembolism (VTE). However little is known about the use of DOACs in daily practice.MethodsWe used the RIETE registry to identify predictors of use of DOACs for initial and/or long-term therapy of VTE based on patient-related factors, institution-related factors or over time.ResultsAmong 41,678 patients from March 2013 to September 2021, 12,286 (29%) used DOACs: for initial therapy 6,456; for long-term therapy 12,046. On multivariable analysis, independent predictors were: age &lt; 65 years (odds ratio [OR]: 1.30; 95% CI: 1.23–1.38), body weight &lt;50 kg (OR: 0.54; 95% CI: 0.45–0.65) or &gt;120 kg (OR: 0.64; 95% CI: 0.53–0.77), initial VTE presentation as pulmonary embolism (OR: 1.18; 95% CI: 1.13–1.25), recent bleeding (OR: 0.53; 95% CI: 0.45–0.63), renal insufficiency (OR: 0.44; 95% CI: 0.38–0.51), liver cirrhosis (OR: 0.32; 95% CI: 0.20–0.52), thrombocytopenia (OR: 0.40; 95% CI: 0.34–0.49), atrial fibrillation (OR: 1.58; 95% CI: 1.42–1.75) and prior VTE (OR: 1.14; 95% CI: 1.06–1.22). The DOACs were more likely used in other European countries (OR: 8.97; 95% CI: 8.49–9.49), America (OR: 6.35; 95% CI: 5.67–7.11) or in other countries of the world (OR: 2.99; 95% CI: 2.70–3.31) than in Spain, and progressively increased from 2013–2015 to 2016–2018 (OR: 2.78; 95% CI: 2.62–2.95) and 2019–2021 (OR: 6.36; 95% CI: 5.95–6.80).ConclusionIn this large multinational VTE registry, variations were observed in the use of DOACs according to patient or country factors, and over time. The safety, costs, and influence of the DOACs on VTE-related outcomes in daily practice warrant further investigation.