bluuebunny/crossref_metadata_2025_split huggingface dataset:
Il tempo e la crisi. Analisi di un binomio costitutivo della modernità europea
Authors: Ampollini Andrea 
Published: October 2022

This article aims to reconstruct the history of the concept of crisis and its links with the main temporal models of European modernity, paying particular attention to Marxian thought and to some of the most significant critiques that have been addressed to it. During this historical and conceptual analysis, three objectives will be basically pursued: firstly, to show the positive meaning that ‘crisis’ has assumed within the modern philosophies of history and to investigate its debts with the Judeo-Christian tradition; secondly, to prove that Marx did not intend to support, as he has often been accused of, any staged and linear conception of history, but rather to highlight the existence of different temporal strata, within which ‘crisis’ does not produce any forced outcome; finally, to analyze how, between the nineteenth and the twentieth centuries, authors like Nietzsche and Spengler tried to eliminate – without succeeding – faith in historical progress.
Salvador Luria
Authors: Selya Rena 
Published: October 2022

The life of Nobel-winning biologist Salvador Luria, whose passion for science was equaled by his commitment to political engagement in Cold War America.
Blacklisted from federal funding review panels but awarded a Nobel Prize for his research on bacteriophage, biologist Salvador Luria (1912–1991) was as much an activist as a scientist. In this first full-length biography of Luria, Rena Selya draws on extensive archival research; interviews with Luria's family, colleagues, and students; and FBI documents obtained through the Freedom of Information Act to create a compelling portrait of a man committed to both science and society.
In addition to his work with viruses and bacteria in the 1940s, Luria broke new ground in molecular biology and cancer research from the 1950s to the 1980s and was a leader in calling for scientists to accept an educational and advisory responsibility to the public. In return, he believed, the public should rely on science to strengthen social and political institutions.
Luria was born in Italy, where the Fascists came to power when he was ten. He left Italy for France due to the antisemetic Race Laws of 1938, and then fled as a Jewish refugee from Nazi Europe, making his way to the United States. Once an American citizen, Luria became a grassroots activist on behalf of civil rights, labor representation, nuclear disarmament, and American military disengagement from the Vietnam and Gulf Wars. Luria joined the MIT faculty in 1960 and was the founding director of the Center for Cancer Research. Throughout his life he remained as passionate about his engagement with political issues as about his science, and continued to fight for peace and freedom until his death.
Pattern of Neonatal Mortality at a Special Care Baby Unit in Rivers State, Nigeria
Authors: West Boma Awoala , Onubogu Uchenna , Arthur Adaku 
Published: October 2022

Background: Neonatal mortality rate is an important indicator which does not only reflect the overall health of a child and well-being but also assesses the social and economic development of a country.
Aim: The study was carried out to determine the pattern and factors associated with neonatal mortality.
Methods and Materials: It was a retrospective study carried out in the Special care Baby Unit of the Rivers State University Teaching Hospital from January 2016 to December 2020.
Results: Of 2,944 neonatal admissions, 358 died giving a mortality of 12.2% with male preponderance (M:F ratio of 1.5:1). Majority of the neonates who died were admitted within the first 24 hours of life 289(80.7%) and were delivered via Caesarean section 195(54.4%). Most deaths occurred in the first 7 days of life 189(52.8%). The commonest cause of mortality was neonatal sepsis 183 (51.1%) followed by perinatal asphyxia 178(49.7%) and prematurity 176(49.2%). Most mortalities occurred between 4.00pm and 7.59 am 218(61.0%) outside regular work hours. The lowest annual mortality was recorded in the year 2020 (6.36%) while the highest was in the year 2018 (19.27%). There was significant mortality within 24hours of admission among neonates < 1.5 kg as well as those with sepsis, anaemia and neonatal jaundice.
Conclusion: The mortality rate of neonates in the Rivers State University Teaching Hospital was high, 12.2% with neonatal sepsis, perinatal asphyxia and prematurity being the commonest causes which are largely preventable. There is therefore need to improve obstetric and newborn care to improve neonatal outcome.
Non-commutativity Over Canonical Suspension η for Genus g ≥1 in Hypercomplex Structures for Potential ρϕ
Authors: Bhattacharjee Deep 
Published: October 2022

Any matrix multiplication is non-commutative which has been shown here in terms of suspension‡, annihilator, and factor as established over a ring following the parameter k over a set of elements upto n for an operator to map the ring R to its opposite Rop having been through a continuous representation of permutation upto n-cycles being satisfied for a factor f along with its inverse f-1 over a denoted orbit γ on k-parameterized ring justified via suspension η ∈ η0, η1 implying the same global non-commutativity for the annihilator A. This will be used for the construction of the genus–alteration scenario where the suspension η0 acting with its opponent η1 on any topological space J can alter the geometry making a change in the manifolds for taking over the Boolean (1,0) satisfying the concerned operations.
Pathological Impact and Disease Burden of Human Onchocerciasis in Endemic Areas of Delta State, Nigeria
Authors: Onojafe J. O. , Egwunyenga A. O. , Eke S. S. 
Published: October 2022

Background to the Study/Aim: The context of onchocerciasis being one of the neglected tropical diseases (NTDs) in Nigeria; and the predicted increase in the rate of spread of tropical diseases and vectors to higher altitude, as a result of climate change and global warming, underscores the need for more studies on the disease. Thus, this research was conducted to examine the pathological impact and disease burden of human onchocerciasis on the infected in endemic communities in three local government areas of Delta State, Nigeria.
Materials and Methods: The study was carried out in two phases. The first phase involved four stages. Stage one was visual acuity test on those who volunteered to take part in the research. Stage two was the physical examination of individuals for characteristic onchocercal lesions. The third stage was the collection of skin snips from individuals while the fourth stage was microscopic examination of the skin snips for microfilariae of Onchocerca volvulus. The second phase examined the impact of the disease and was carried out with the aid of a structured questionnaire.
Results: The results showed that human onchocerciasis existed in the study area. Out of the 1,201 persons, comprising of 826 (68.8%) males and 375 (31.2%) females examined, 138 were positive for the onchocercal parasite. The infected, consisted of 101 (12.2%) males and 37 (9.9%) females. Generally, infected persons had manifestations ranging from ocular defects, visual problems to skins disfiguration.
Conclusion: In addition to the administration of ivermectin and vector control, psychosocial and economic needs of the infected should be addressed through counseling and offering of palliating assistance to reduce their economic problems and give them feeling of independence.
A Case Report of Delayed Syphilis Diagnosis in Pregnancy
Authors: Raminta Stuopelytė , Dalia Laužikienė , Algirdas Šumila 
Published: October 2022

Aims: To report a case of primary genital syphilis in a pregnant woman, which is atypical due to the delayed diagnosis, course of the disease and to emphasize its reasons and clinical management.
Presentation of Case: We present a pregnant primiparous woman G1P0A0 complaining of pain and growing lesion in the perineal area. She was misdiagnosed and unsuccessfully treated for the perineal abscess several times. The diagnosis of syphilis was delayed because of the negative prenatal syphilis test result in the first trimester. The negative test result misled doctors into immediately dismissing the diagnosis of syphilis. In addition to the delayed diagnosis, after the correct diagnosis regardless of an appropriate treatment with benzathine penicillin G, the pain and the chancre recurred possibly due to the reinfection during intercourse with an infected partner.
Discussion: Diagnosing syphilis may be complicated itself. In this case there were several factors that made the correct diagnosis and successful treatment even more difficult. These were: negative prenatal screening, reinfection and recurrence of the symptoms after treatment.
Conclusion: With this case we emphasize the importance to repeat the syphilis testing if the diagnosis of syphilis is suspected, regardless of previous negative first trimester syphilis screening result and importance of sexual partner’s screening and treatment if infected.
Effect of Supplementation of Concentrate Containing ZnSO4 and Zn-Cu Isoleucinate on Growth and Post Partum Reproductive Performance of Bali Cows Grazing Native Pastures
Authors: Hartati E. , Telupere F. M. S. , Kleden M. M. , Lestari G. A. Y. , Oematan G. , Ola A. R. B. , Jelantik I. G. N. 
Published: October 2022

Aims: This research was carried out to evaluate effect of supplementation of ZnSO4 and Zn-Cu isoleucinate into Complete Feed Plus (CFP) on the growth in the last period of pregnancy and the post partum reproduction efficiency of Bali cows reared semi-intensively.
Study Design: The experiment employed twenty seven Bali cows at the last period of pregnancy. The animals were grouped into three treatment groups consisted of grazing on the nearby pasture without supplement (R0), and supplemented with either Gliricidia and Leucaena leaves (R1), or with concentrate supplement containing 150 mg ZnSO4 kg-1 PCF DM and 2% Zn-Cu isoleucinate kg-1 diet DM (R2). Data collected was then analyzed using analysis of variance and then Duncan’s multiple range test for further test by using SPSS package Release 19.
Results: Results showed that supplementation with concentrate containing 150 mg ZnSO4.kg-1 DM PCF and 2% Zn-Cu isoleucinate.kg-1 DM diet increased significantly (P<0,01) the rumen propionate concentration, NH3-N concentration, plasma glucose, N and energy retention, daily gain of Bali cows in the last period of pregnancy, calf birth weight, estrous cycle and estrous post partum acceleration, and body weight of weaned calves. Average daily gain of Bali cows in the last period of pregnancy, calf birth weight, body weight of the weaned calves, estrous cycle and post-partum estrous were found on feed supplement treatment containing 150 mg ZnSO4 kg-1 DM of PCF and 2% Zn-Cu isoleucinate kg-1 DM of diet.
Conclusion: Supplementing grazing Bali cows with concentrate containing 150 mg ZnSO4.kg-1 DM PCF and 2% Zn-Cu isoleucinate.kg-1 DM diet improved calf’s birth weight and postpartum reproductive performance.
Seroprevalence of Hepatitis A Infection among Young Adults in Ilorin
Authors: Pius Omosigho Omoruyi , Daniel Ugbomoiko , Esther James Omolola , Ekundayo Izevbuwa Osazee , David Akinola Ayoola , Anthony Otojareri Kohwo 
Published: October 2022

Hepatitis A infection is predominantly caused by Hepatitis A virus which is transmitted by fecal-oral route through contaminated food or drinks. The virus’s ability to cause hepatitis poses as a major hazard to public health. This study was done to discover the widespread presence of hepatitis A among young adults in Ilorin, Kwara State. A Cross sectional sampling technique was employed to select the study population. Semi-structured questionnaire was used to acquire demographic information of the cohorts. Four hundred (400) young adults residing in Ilorin were the participants in the study.
Five mls of venous blood sample were obtained from each of the participants through venipuncture technique. The blood samples were separated and the serum used for qualitative analysis of hepatitis A virus IgG using EIA and indirect ELISA technique (Abbexa Ltd, UK).
Out of the four hundred (400) healthy young adult subjects, an overall distribution of 1.5% IgG Hepatitis A were found among participants in Ilorin. Fulminant stooling, location, gender, educational level, age and occupation were risk factors for acquiring Hepatitis A infection. There was significant difference between Hepatitis A infection and Fulminant stooling (p<0.05). Previous history of blood transfusion was not statistically associated as a potential risk factor for Hepatitis A infection among Inhabitants in Ilorin. High prevalence of anti-hepatitis A virus IgG levels of the antibody was reported among young adult in this study. Based on the findings of this study, screening of hepatitis A virus for blood transfusion and food vendors, personal hygiene are highly advocated.
Conflict Management inside EAEU to Preserve Its Forum
Authors: Roedyati Joevi 
Published: October 2022

Eurasian Economic Union members: The Eurasian Economic Union consists of five member states: Russia, Belarus, Kazakhstan, Kyrgyzstan, and Armenia.
What is the Eurasian Economic Union?
The Eurasian Economic Union (EEU or EAEU is a project for the economic integration of the former Soviet region. Its formal objectives are to create a common market much like the European Union (EU). There are four targets of this forum, i.e:1) coordinating economic policy, 2.) eliminating non-tariff trade barriers,3) harmonizing regulations, and 4).modernizing the economies of its five member states. While the whole population of EEU member states is estimated 180 million people.
The EEU has some institutions inside it, i.e: the Eurasian Economic Commission in Moscow as its regulatory body, and a Court of the Eurasian Economic Union based in Minsk. The Commission's power is limited. Member states disagreeing with its judgments can appeal to other bodies, and the Commission has no power to bring a member state before the Court in a case of non-compliance. Disputes are often resolved bilaterally rather than via EAEU institutions.
Bureaucratic forms of the EU have not been fully copied by the EAEU, which seems a slow phase of its development so far. This is might be caused by EAEU GDP in 2019 being the majority Russian economy (87%). Russia is by far the largest member state and dominates the Union. This domination means that Russia is easily able to act unilaterally within the union [1].
Multisensory encoding of names via name tags facilitates remembering
Authors: Murray Carolyn A. , Tarlow Maisy , Rissman Jesse , Shams Ladan 
Published: October 2022

AbstractAssociating names to faces can be challenging, in part because this task lacks an inherent semantic relationship between a face and name. The current study seeks to understand whether bolstering names with cross‐modal cues—specifically, name tags—may aid memory for face and name pairings. In a series of five experiments, we investigated whether the presentation of congruent vocalized and written names at encoding might benefit subsequent cued recall and recognition memory tasks. The results showed that participants, cued with a picture of a face, were more likely to recall the associated name when those names were encoded with a name tag (a congruent visual cue) compared to when no supporting cross‐modal cue was available. The findings were consistent with a benefit of multisensory encoding, above any effect from the availability of independent unisensory traces, extending previous findings of multisensory learning and memory benefits to a naturalistic associative memory task.
Investigation of a failed DNA assay leads to identification of an unexpected contaminant in a commonly used chromatography buffer
Authors: Kuhns Scott T. , Semin David J. , Soice Neil P. , Kappes Andy , Wong H. Edward , Hwang Tsang‐Lin , Soto Robert J. , Csordas Andrew T. , Wu Alexander , Martinez‐Cano Diandra , Babayan Melin , Pelayo Yesenia , Hammond Matthew R. , Nashed‐Samuel Yasser , Goudar Chetan T. 
Published: October 2022

AbstractFor mammalian cell‐derived recombinant biotherapeutics, controlling host cell DNA levels below a threshold is a regulatory requirement to ensure patient safety. DNA removal during drug substance manufacture is accomplished by a series of chromatography‐based purification steps and a qPCR‐based analytical method is most used to measure DNA content in the purified drug substance to enable material disposition. While the qPCR approach is mature and its application to DNA measurement is widespread in the industry, it is susceptible to trace levels of process‐related contaminants that are carried forward. In this study, we observed failures in spike recovery studies that are an integral component of the qPCR‐based DNA testing, suggesting the presence of an inhibitory compound in the sample matrix. We generated hypotheses around the origin of the inhibitory compound and generated multiple sample matrices and deployed a suite of analytical techniques including Raman and NMR spectroscopy to determine the origin and identity of the inhibitory compound. The caustic wash step and depth filter extractables were ruled out as root causes after extensive experimentation and DNA testing. Subsequently, 2‐(N‐morpholino)ethanesulfonic acid (MES), a buffer used in the chromatography unit operations, was identified as the source of the contaminant. A 500‐fold concentration followed by Raman and NMR spectroscopy analysis revealed the identity of the inhibitory compound as polyvinyl sulfone (PVS), an impurity that originates in the MES manufacturing process. We have implemented PVS concentration controls for incoming MES raw material, and our work highlights the need for rigor in raw material qualification and control.
Assessing early changes in plasma HER2 levels is useful for predicting therapeutic response in advanced breast cancer: A multicenter, prospective, noninterventional clinical study
Authors: Kang Yi‐Kun , Si Yi‐Ran , Ju Jie , Jia Zhu‐Qing , Hu Nan‐Lin , Dong Hao , Wang Xue , Yue Jian , Jiang Pei‐Di , Li Zhao‐Liang , Zhang Yun‐Yun , Wang Yan , Xu Bing‐He , Yuan Peng 
Published: October 2022

AbstractBackgroundEarly prediction of treatment response is crucial for the optimal treatment of advanced breast cancer. We aimed to explore whether monitoring early changes in plasma human epidermal growth factor receptor 2 (HER2) levels using digital PCR (dPCR) could predict the treatment response in advanced breast cancer.MethodsThis was a multicenter, prospective, noninterventional clinical study of patients with advanced breast cancer. All enrolled patients underwent blood testing to measure the HER2 levels by digital PCR before treatment initiation and once every 3 weeks during the study. The primary endpoints werea the diagnostic value of dPCR for detecting HER2 status in the blood andb the relevance of potential changes in the plasma HER2 level at 3 weeks from baseline for predicting treatment response.ResultsOverall, 85 patients were enrolled between October 9, 2018, and January 23, 2020. dPCR had a specificity of 91.67% (95% CI: 80.61% to 97.43%) for detecting HER2 amplification, and the area under the receiver operating characteristic (ROC) curve was 0.84 (p < 0.01). A clinically relevant specificity threshold of approximately 90%, which was equivalent to a ≥15% decrease in the plasma HER2 ratio at 3 weeks from baseline, showed a positive predictive value of 97.37% (95% CI: 77.11% to 98.65%) in terms of predicting clinical benefit. Patients whose plasma HER2 ratio was reduced by ≥15% had a longer median progression‐free survival (PFS) than those whose ratio was reduced by <15% (9.20 months vs. 4.50 months, p < 0.01).ConclusionsEarly changes in the plasma HER2 ratio may predict the treatment response in patients with advanced breast cancer and could facilitate optimal treatment selection.
The paired‐related homeobox protein 1 promotes cardiac fibrosis via the Twist1‐Prrx1‐tenascin‐C loop
Authors: Wang Fengyuan , Zhao Hongyi , Yin Lin , Zhang Wei , Tang Yanhong , Wang Xi , Huang Congxin 
Published: October 2022

AbstractCardiac fibrosis is a common pathology in the advanced stage of cardiovascular diseases, which leads to cardiac systolic and diastolic dysfunction. It is important to prevent cardiac fibrosis during myocardial injury. The transcription factor Prrx1 is involved in cancer‐associated fibrosis and other organ fibrosis. However, the role and mechanism of Prrx1 in cardiac fibrosis deserves further exploration. We identified that overexpressed Prrx1 promoted the proliferation and migration of cardiac fibroblasts, and transform cardiac fibroblasts to myofibroblasts in vitro. We demonstrated that the expression of Prrx1 is upregulated in TGF‐β1‐treated fibroblasts. And silencing Prrx1 could attenuate cardiac fibrosis induced by TGF‐β1 in vitro. In addition, a Twist1‐paired‐related homeobox 1 (Prrx1)‐tenascin‐C (TNC) positive feedback loop (PFL) combined with Twist1, Prrx1, and TNC activated fibroblasts, which was the mechanism the Prrx1 in cardiac fibrosis. In conclusion, our findings showed that the deficiency of Prrx1 attenuated cardiac fibrosis in vitro and reveal a novel Twist1‐Prrx1‐TNC PFL in the regulation of cardiac fibrosis.
Liquid–liquid equilibria of ternary mixtures of methanol + MEG + n‐C5, ethanol + MEG + n‐C5, and n‐butanol + MEG + n‐C5
Authors: Mascietti Vanessa A. , Farias Larissa Silva , Tavares Frederico W. , Ndiaye Papa M. 
Published: October 2022

AbstractNew liquid–liquid equilibrium data of ternary systems of mono ethylene glycol + n‐pentane + methanol, mono‐ethylene glycol (MEG) + n‐pentane + ethanol, and mono ethylene glycol + n‐pentane + n‐butanol from 283.15 to 293 K are presented in this work. Binodal curves were obtained by the cloud point titration method. Tie‐line compositions were obtained through density and sound velocity measurements of phases in equilibrium. Results show that the solubility increases with temperature in all systems and decreases as the alcohol chain increases. The relative solubility data indicate that the alcohols are more soluble in MEG than in n‐C5. The obtained experimental data were successfully correlated using the CPA and the PC‐SAFT equation with appropriate binary interaction parameters.
NLSP: A novel lattice‐based secure primitive for privacy‐preserving smart grid communications
Authors: Bao HaiYong , Xu Zheng , Hong HaiBo , Kong QingLei , Qian HaiFeng 
Published: October 2022

SummaryAs the new generation of power scheme, smart grid is proposed to overcome the shortcomings of traditional systems, such as low efficiency and reliability. In this article, a novel lattice‐based secure primitive for privacy‐preserving smart grid communications is proposed, which has the remarkable characteristics, such as scalable multi‐dimensional fine‐grained power data structure and differential privacy security. First, combining with the lattice‐based data encryption technology, while effectively resisting quantum attacks, the method of simultaneous processing of multi‐dimensional data is innovated. Second, through combining the additive homomorphism of the lattice‐based cryptosystem and the Chinese remainder theorem, the data aggregation mechanism that can directly perform homomorphic operations on compressed ciphertext is constructed. Thanks to the above innovative design ideas, the proposed scheme not only significantly improves the efficiency of data communication and processing, greatly reduces the computational cost of the intermediate entity, but also realizes the data confidentiality and information privacy. Finally, observing the decentralized topology of communication nodes in the typical cyber‐physical system of smart grid, the localized differential privacy technology is leveraged to optimize and balance the utility, security, and efficiency of differential privacy. Extensive performance evaluations are conducted to illustrate that the proposed scheme outperforms the state‐of‐the‐art similar schemes in terms of computation complexity and communication cost.