bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of Love and Infidelity by Polish Youth
Authors: Wróblewska-Skrzek Joanna 
Published: August 2022

AbstractThe article presents results of research on academic youth attitudes on love, intimacy, and infidelity in Poland. The research goal was to determine how modern adolescents define a relationship, what role is played in this regard by the sociocultural understanding of love they adopted, and how their ideas about relationship and love translate into faithfulness in the relationship. The research was conducted using quantitative methods with computer assisted (aided) web interviews on an Internet channel supervised by Lime-Survey system. The study was of an exploratory character; it used N = 621 of full questionnaires. Factor analysis enabled distinguishing three analytic areas: relationship, infidelity and causes of infidelity. Within every definitional range, the number of variables extracted from the question pool was reduced to two dimensions. In each case, the definitional variants clearly fit into a distinct dualism of cultural forms of love, which distinguished between romantic love and pure relationship. Young people’s attitudes towards love and infidelity are full of contradictions and paradoxes. On the one hand, they look for romantic love, on the other, one can observe a need of sexual experiences and pleasures. Adolescents define infidelity in corporal terms, but they do not forget about its emotional aspect. Their opinions about infidelity point to a rather elusive nature of traditionally applying norms and prohibitions. What is crucial in this regard is the way the relationship is perceived and the strength of emotional involvement and ties binding the couple.
Lukea gen. nov. (Monodoreae-Annonaceae) with two new threatened species of shrub from the forests of the Udzungwas, Tanzania and Kaya Ribe, Kenya
Authors: Cheek Martin , Luke W. R. Quentin , Gosline George 
Published: August 2022

SummaryA new genus, Lukea Cheek & Gosline (Annonaceae), is erected for two new species to science, Lukea quentinii Cheek & Gosline from Kaya Ribe, SE Kenya, and Lukea triciae Cheek & Gosline from the Udzungwa Mts, Tanzania. Lukea is characterised by a flattened circular bowl-shaped receptacle-calyx with a corolla of three free petals that give the buds and flowers a unique appearance in African Annonaceae. Both species are extremely rare shrubs of small surviving areas of lowland evergreen forest under threat of habitat degradation and destruction and are provisionally assessed as Critically Endangered and Endangered respectively using the IUCN 2012 standard. Both species are illustrated and mapped. Material of the two species had formerly been considered to be possibly Uvariopsis Engl. & Diels, and the genus Lukea is placed in the Uvariopsis clade of the Monodoreae (consisting of the African genera Uvariodendron (Engl. & Diels) R.E.Fries, Uvariopsis, Mischogyne Exell, Dennettia Baker f., and Monocyclanthus Keay). The clade is characterised by often conspicuous, finely reticulate quaternary nervation, incomplete or absent connective shields (in Annonaceae the connective shield is usually complete) and free petals (except in some Uvariopsis). Morphologically Lukea is distinct for its broad, turbinate, fleshy pedicel, a potential synapomorphy within Monodoreae. It appears closest morphologically to the West African monotypic Monocyclanthus, since it shares a trait unusual in the Annonaceae: the calyx in both genera forms a shallow bowl (calyx lobes are absent or vestigial), barely enclosing the base of the petals at anthesis, which persists, living and green, in the mature fruit. However, on recent molecular phylogenetic evidence, Lukea is sister to Mischogyne and the two split c. 20 million years BP, while Monocyclanthus is sister to Dennettia. The placement of Lukea within the Uvariopsis clade is discussed.
Magnetic Resonance T1w/T2w Ratio in the Putamen and Cerebellum as a Marker of Cognitive Impairment in MSA: a Longitudinal Study
Authors: Cuoco Sofia , Ponticorvo Sara , Bisogno Rossella , Manara Renzo , Esposito Fabrizio , Di Salle Gianfranco , Di Salle Francesco , Amboni Marianna , Erro Roberto , Picillo Marina , Barone Paolo , Pellecchia Maria Teresa 
Published: August 2022

AbstractThe exact pathophysiology of cognitive impairment in multiple system atrophy (MSA) is unclear. In our longitudinal study, we aimed to analyze (I) the relationships between cognitive functions and some subcortical structures, such as putamen and cerebellum assessed by voxel-based morphometry (VBM) and T1-weighted/T2-weighted (T1w/T2w) ratio, and (II) the neuroimaging predictors of the progression of cognitive deficits. Twenty-six patients with MSA underwent a comprehensive neuropsychological battery, motor examination, and brain MRI at baseline (T0) and 1-year follow-up (T1). Patients were then divided according to cognitive status into MSA with normal cognition (MSA-NC) and MSA with mild cognitive impairment (MCI). At T1, we divided the sample according to worsening/non worsening of cognitive status compared to baseline evaluation. Logistic regression analysis showed that age (β =  − 9.45, p = .02) and T1w/T2w value in the left putamen (β = 230.64, p = .01) were significant predictors of global cognitive status at T0, explaining 65% of the variance. Logistic regression analysis showed that ∆-values of WM density in the cerebellum/brainstem (β = 2188.70, p = .02) significantly predicted cognitive worsening at T1, explaining 64% of the variance. Our results suggest a role for the putamen and cerebellum in the cognitive changes of MSA, probably due to their connections with the cortex. The putaminal T1w/T2w ratio may deserve further studies as a marker of cognitive impairment in MSA.
The role of highly intercited papers on scientific impact: the Mexican case
Authors: Dorantes-Gilardi Rodrigo , Ramírez-Álvarez Aurora A. , Terrazas-Santamaría Diana 
Published: August 2022

AbstractThe present paper explores the relationship between highly intercited papers in the k-max of citation networks and an author’s impact from the Mexican National System of Researchers (SNI). We investigate whether a more interconnected network, a higher k of the k-max, explains the variation of the total number of citations, controlling for personal characteristics such as SNI level, area of expertise, and the number of publications. We find that the k-max is positively and significantly correlated with impact. In this context, we find that the share of self and collaborator-citations increases with the magnitude of the k-max and women tend to have less interlinked cores of their citation networks than men (smaller k’s). Interestingly, we find that women tend to have a higher share of third-party citations while men tend to have a higher share of self and collaborator-citations, for all k’s and areas of expertise. We conduct a Blinder–Oaxaca decomposition to better understand the citation gender gap and find that much of it can be explained through the differences in observable characteristics (including the k-max) between women and men.
Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Protective Mechanisms in Preeclampsia
Authors: Vignato Julie A. , Gumusoglu S. Banu , Davis Heather A. , Scroggins Sabrina M. , Hamilton Wendy S. , Brandt Debra S. , Pierce Gary L. , Knosp Boyd A. , Santillan Donna A. , Santillan Mark K. 
Published: August 2022

AbstractDepression and preeclampsia share risk factors and are bi-directionally associated with increased risk for each other. Despite epidemiological evidence linking selective serotonin reuptake inhibitors (SSRIs) in pregnancy to preeclampsia, serotonin (5-HT) and vasopressin (AVP) secretion mechanisms suggest that SSRIs may attenuate preeclampsia risk. However, there is a need to clarify the relationship between SSRIs and preeclampsia in humans to determine therapeutic potential. This retrospective cohort study included clinical data from 9558 SSRI-untreated and 9046 SSRI-treated pregnancies. In a subcohort of 233 pregnancies, early pregnancy (< 20 weeks) maternal plasma copeptin, an inert and stable AVP prosegment secreted 1:1 with AVP, was measured by enzyme-linked immunosorbent assay. Diagnoses and depression symptoms (Patient Health Questionnaire-9 [PHQ-9]) were identified via medical records review. Descriptive, univariate, and multivariate regression analyses were conducted (α = 0.05). SSRI use was associated with decreased preeclampsia after controlling for clinical confounders (depression severity, chronic hypertension, diabetes, body mass index, age) (OR = 0.9 [0.7–1.0], p = 0.05). Moderate-to-severe depression symptoms were associated with significantly higher copeptin secretion than mild-to-no depression symptoms (240 ± 29 vs. 142 ± 10 ng/mL, p < 0.001). SSRIs significantly attenuated first trimester plasma copeptin (78 ± 22 users vs. 240 ± 29 ng/ml non-users, p < 0.001). In preeclampsia, SSRI treatment was associated with significantly lower copeptin levels (657 ± 164 vs. 175 ± 134 ng/mL, p = 0.04). Interaction between SSRI treatment and preeclampsia was also significant (p = 0.04). SSRIs may modulate preeclampsia risk and mechanisms, although further studies are needed to investigate the relationships between 5-HT and AVP in depression and preeclampsia.
Graphical abstract
Analysis of risk factors related to severe postpartum hemorrhage of twin pregnancies delivered by cesarean section
Authors: Yin Fufen , Li Ruixue , Xie Junshu , Zhang Xiaohong 
Published: August 2022

AbstractObjectiveTo investigate the risk factors of severe postpartum hemorrhage (PPH) in cesarean section of twin pregnancy, and to provide clinical basis for pregnancy management and perioperative obstetric management of twin pregnancy.MethodsThe clinical data of 631 twin pregnancies with gestational age ≥28 weeks delivered by cesarean section at Peking University People's Hospital (PKUPH) from January 2004 to January 2017 were retrospectively analyzed. Methods of conception, the combined weight of twins, serum albumin level before cesarean section, operation time and other factors on the amount of blood loss during cesarean section were analyzed.ResultsThe proportion of severe PPH was significantly higher in in vitro fertilization-embryo transfer (IVF-ET) group, the combined weight of twins > 6000g group, serum albumin before cesarean section < 30 ​g/dl group than in the natural pregnancy group, 4000–6000g group, < 4000g group and serum albumin ≥30 ​g/dl group respectively (P ​< ​0.05). The proportion of severe PPH in the elective surgery group of twin pregnancy was higher than that in the emergency surgery group, but the difference was not statistically significant (P ​> ​0.05). Moreover, according to the surgical indications, the emergency surgery group was divided into premature rupture of membranes (PROM), labor, fetal distress and others groups, no significant difference were detected among these groups (P>0.05).ConclusionIVF-ET, the combined weight of twins, serum albumin before operation were significantly correlated with severe PPH of twin pregnancies delivered by cesarean section, revealing that it is necessary to strengthen pregnancy management of twin pregnancy.
Prognostic Implications of Early Albuminocytological Dissociation in Guillain–Barré Syndrome
Authors: Vargas-Cañas Edwin Steven , Galnares-Olalde Javier Andrés , León-Velasco Fausto , García-Grimshaw Miguel , Gutiérrez Alonso , López-Hernández Juan Carlos 
Published: August 2022

ABSTRACT:Background:Half of Guillain–Barré syndrome (GBS) present elevated cerebrospinal fluid (CSF) protein levels within 1 week since symptom onset and 80% within 2 weeks. Our objective was to determine the clinical and prognostic implication of albuminocytological dissociation in early GBS.Methods:An ambispective cohort study was conducted. Good outcome was considered if the patient was able to walk unaided (Guillain-Barré disability score [GDS] ≤ 2 points) at 3-month follow-up. Patients were classified into two groups: with and without albuminocytological dissociation; we compared clinical and paraclinic characteristics between the groups. We analyzed clinical and electrophysiological factors related to presenting early dissociation through a multivariate model.Results:We included 240 patients who fulfilled Asbury criteria for GBS. On further selection, only 94 patients fulfilled inclusion. Mean age was 45.94 ± 17.1 years and 67% were male. Median time from symptom onset to admission was 5 days (IQR 3–6). Regarding albuminocytological dissociation and electrophysiological variants, we found a significant difference: acute inflammatory demyelinating polyneuropathy (AIDP) [60.6% vs 26.2%,p= 0.002], acute motor axonal neuropathy (AMAN) [21.2% vs 49.1%,p= 0.009] and acute motor sensory axonal neuropathy (AMSAN) [12.1% vs 1.6%,p= 0.05]. We did not observe significant differences in recovery of independent walking in short term between both groups. The presence of conduction block in any variant (OR 3.21, 95% CI 1.12–9.16,p= 0.02) and absence of sural registration (OR 5.69, 95% CI 1.48–21.83,p= 0.011) were independent factors related to early dissociation.Conclusions:Early dissociation (<7 days) is not associated with any particular clinical feature or unfavorable outcome. It is more common to see in AIDP rather than axonal variants.
Developing an engaging and accessible clinical research training program for new investigators
Authors: Markman Kris M. , Brewer Sarah K. , Klein Andreas K. , Magnuson Britta 
Published: August 2022

Abstract
Clinicians who are interested in becoming principal investigators struggle to find and complete training that adequately prepares them to conduct safe, well-designed clinical and translational research. Degree programs covering these skills require a significant time investment, while online trainings lack engagement and may not be specific to local research contexts. Staff at Tufts Clinical and Translational Science Institute sought to fill the gap in junior investigator training by designing an eight-module, noncredit certificate program to teach aspiring clinician-investigators about good clinical practice, clinical research processes, and federal and local regulatory requirements. The first iteration of this program was evaluated using pre- and posttest questionnaires and by gathering clinician learner feedback in a focus group. Based on the pre- and posttest questionnaires, learners experienced an increase in self-efficacy and confidence related to clinical research competencies. Feedback from learners also highlighted important program strengths, including an engaging program format, a manageable time commitment, and an emphasis on identifying crucial research resources. This article describes one approach to creating a meaningful and efficient clinical trial training program for clinicians.
Mental health implications on Afghan children: an impending catastrophe
Authors: Qamar Khulud , Priya  , Rija Aiman , Vohra Laiba Imran , Nawaz Faisal A. , Essar Mohammad Yasir 
Published: August 2022

AbstractAfghan children have suffered for decades because of chronic socioeconomic health crises. The current state of Afghanistan has deprived the basic human needs of children. The lack of freedom leaves their voices unheard, causing detrimental effects on their mental health. Mental illnesses such as post-traumatic stress disorder, anxiety, and depression are prevalent in Afghanistan, causing severe negative outcomes among children. Promotion of mental health services, psychological training, awareness campaigns, acceptance of Afghan refugees, and initiatives to support re-connecting with loved ones, are among the many recommended measures needed to manage this alarming situation. This requires an immediate action plan from government and public health officials to mitigate this impending catastrophe.
Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice
Authors: Becari Luca , Fonseca Maria Luiza A. , Gonçalves Sthéfanie C. A. , Bader Michael , Santos Robson A. S. , Campagnole-Santos Maria José , Kangussu Lucas M. 
Published: August 2022

AbstractObjectives:To evaluate the impact of genetic deletion of receptors of the counterregulatory arms of the renin–angiotensin system in depressive-like behaviours.Methods:8–12 weeks-old male mice wild type (WT, C57BL/6J) and mice with genetic deletion of MrgD (MrgD KO) or Mas receptors (Mas KO) were subjected to the Forced Swim Test (FST) and the Tail Suspension Test (TST). Brain-derived neurotrophic factor (BDNF) levels were measured by enzyme-linked immunosorbent assay (ELISA). Blockade of Mas was performed by acute intracerebroventricular (icv) injection of its selective antagonist, A779.Results:No statistical difference in immobility time was observed between MrgD KO and WT male animals subjected to FST and TST. However, acute icv injection of A779 significantly increased the immobility time of MrgD KO male mice subjected to FST and TST, suggesting the involvement of Mas in preventing depressive-like behaviour. Indeed, Mas KO male animals showed increased immobility time in FST and TST, evidencing a depressive-like behaviour in these animals, in addition to a reduction in BDNF levels in the prefrontal cortex and hippocampus. No changes in BDNF levels were observed in MrgD KO male animals.Conclusion:Our data showed that Mas plays an important role in the neurobiology of depression probably by modulating BDNF expression. On the contrary, lack of MrgD did not alter depressive-like behaviour, which was supported by the lack of alterations in BDNF levels.
Effect of live yeast supplementation and feeding frequency in male finishing pigs subjected to heat stress
Authors: Serviento Aira Maye , Castex Mathieu , Renaudeau David , Labussière Etienne 
Published: August 2022

AbstractIn growing pigs, reduced growth during heat stress (HS) is mainly related to decreased feed intake. The study aimed to determine whether the reported positive effects of live yeast (LY) supplementation in HS pigs were due to a modified feeding behaviour or energy metabolism, and if these can be replicated by imposing an increased meal frequency. The effect of LY supplementation (0 (NS) v. 100 (LY) g/ton of feed), and of feeding window (FW) (unlimited or Unli, 2FW of 1 h each and 8FW of 15 min each) were measured in entire male finishing pigs (n 36). Ambient temperature was at 22°C during the thermoneutral (TN) period (5 d) and at 28°C during the HS period (5 d). Heat exposure decreased DM intake (DMI) and retained energy (RE) (–627 and −460 kJ·kg BW–0·60 · d–1, respectively; P < 0·01). During HS, LY supplementation in Unli pigs decreased inter-meal intervals (P = 0·02) attenuating HS effect on DMI which tended to improve RE (P = 0·09). NS – 8FW had higher DMI and RE than NS – 2FW (P < 0·05) but protein deposition (PD) were similar. Supplemented pigs had higher PD during HS regardless of FW (+18 g · d–1; P = 0·03). Comparing the 2FW groups, improved heat tolerance of LY-supplemented pigs were due to improved insulin sensitivity (P < 0·05) and latent heat loss capacity after a meal (P < 0·05) allowing them to increase their DMI (via an increased number of meals) and thus their energy efficiency. Imposing an increased meal frequency improved DMI in HS pigs but did not replicate positive effects of LY on PD.
The impact of pasture and non-pasture diets on the sensory and volatile properties of whole milk powder
Authors: Cheng Zeng , Mannion David T. , O'Sullivan Maurice G. , Miao Song , Kerry Joseph P. , Kilcawley Kieran N. 
Published: August 2022

AbstractThis study evaluated the impact of three distinct diets; perennial ryegrass (GRS), perennial ryegrass/white clover (CLV) and total mixed ration (TMR), on the sensory properties and volatile profile of whole milk powder (WMP). The samples were evaluated using a hedonic sensory acceptance test (n = 99 consumers) and by optimised descriptive profiling (ODP) using trained assessors (n = 33). Volatile profiling was achieved by gas chromatography mass spectrometry using three different extraction techniques; headspace solid phase micro-extraction, thermal desorption and high capacity sorptive extraction. Significant differences were evident in both sensory perception and the volatile profiles of the WMP based on the diet, with WMP from GRS and CLV more similar than WMP from TMR. Consumers scored WMP from CLV diets highest for overall acceptability, flavour and quality, and WMP from TMR diets highest for cooked flavour and aftertaste. ODP analysis found that WMP from TMR diets had greater caramelised flavour, sweet aroma and sweet taste, and that WMP from GRS diets had greater cooked aroma and cooked flavour, with WMP derived from CLV diets having greater scores for liking of colour and creamy aroma. Sixty four VOCs were identified, twenty six were found to vary significantly based on diet and seventeen of these were derived from fatty acids; lactones, alcohols, aldehydes, ketones and esters. The abundance of δ-decalactone and δ-dodecalactone was very high in WMP derived from CLV and GRS diets as was γ-dodecalactone derived from a TMR diet. These lactones appeared to influence sweet, creamy, and caramelised attributes in the resultant WMP samples. The differences in these VOC derived from lipids due to diet are probably further exacerbated by the thermal treatments used in WMP manufacture.
Cochlear implantation in a profoundly deaf child with cystic leukoencephalopathy without megalencephaly
Authors: Gopalakrishnan A , Thangavel S , Chowdhary S , Alexander A 
Published: August 2022

AbstractBackgroundCochlear implantation candidacy criteria have continued to evolve over the years, and cochlear implantation is possible with many inner-ear and brain anomalies with good hearing and linguistic outcomes. Cystic leukoencephalopathy without megalencephaly is a rare disease in children, with only 30 cases reported in the literature, but it is associated with hearing loss in only three cases. Radiological investigations can help in diagnosing this rare entity before proceeding with cochlear implantation.Case ReportA four-year-old female child born out of consanguinity with normal psychomotor development, bilateral sensorineural hearing loss and an incidental magnetic resonance imaging finding of cystic leukoencephalopathy without megalencephaly underwent successful cochlear implantation. Her post-operative period was uneventful with successful mapping of the cochlear implant.ConclusionThis is the first reported case of cystic leukoencephalopathy without megalencephaly and with sensorineural hearing loss in which cochlear implantation was performed successfully. White matter and temporal lobe abnormalities should not deter paediatric cochlear implantation.