bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of set‐based concurrent engineering methodology to the development of cost modeling system for metal casting process
Authors: Sajid Muhammad , Wasim Ahmad , Hussain Salman , Raza Muhammad Huzaifa , Jahanzaib Mirza 
Published: November 2022

AbstractIn recent years, the reliable, accurate, and timely estimate of product cost at the conceptual design stage can enhance the competitiveness of a casting part. Set‐based concurrent engineering has emerged as an efficient solution to overcome this limitation as it provides simultaneous design procedures to positively assist the designer in achieving the required customer values in a short time and low cost. Therefore, this study attempts to integrate the set‐based concurrent engineering methodology into the development of a cost modeling system for the metal casting process. The system architecture is comprised of a user interface, knowledge database, and CAD modeling system. A detailed working flow process of the developed cost modeling system has been proposed under the guidelines of set‐based concurrent engineering. Further, the proposed methodology is demonstrated and validated by employing a real‐time casting part that was manufactured using the sand casting process. The implementation of the system provided many tangible benefits to the collaborative company including a decrease in cost estimation time (∼50%) and part rejection rate (∼32.3%). Further, the developed cost modeling approach provided a cost estimate near the actual cost of the product (∼4% deviation). It truly proves the significance of the developed system for the practitioners who believe that accurate and timely estimates of product manufacturing cost at the design stage can enhance the competitiveness of a product.
CCL3‐CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway
Authors: Guan Bugao , Li Hongbo , Yao Jian , Guo Jinbao , Yu Fei , Li Guangrun , Wan Benhai , Ma Jun , Huang Desong , Sun Lu , Chen Yan 
Published: November 2022

AbstractBackgroundInfiltration of tumor‐associated macrophages (TAMs) can promote tumorigenesis and development. C‐C motif chemokine ligand 3 (CCL3) was reported to be derived from TAMs and tumor cells and facilitate the progression of several cancers. Nevertheless, whether CCL3 can be derived from TAMs and tumor cells of colon adenocarcinoma (COAD) is unclarified.MethodsPeripheral blood monocytes‐derived macrophages were polarized by the conditioned medium from COAD cells to establish TAM‐like macrophages (TAM1/2). RT‐qPCR and western blotting were used for detection of expression levels of CCL3 and its receptors C‐C motif chemokine receptor 1 (CCR1) and CCR5 in TAM1/2 and COAD cells. Immunofluorescence staining was utilized for evaluating CCL3, CD163 and CCR5 expression. The Akt signaling pathway‐associated protein levels were measured by western blotting. Transwell assays were used for assessing cell migration and invasiveness.ResultsCCL3 displayed a high level in TAMs and cancer cells of COAD. CCL3 activated the Akt signaling pathway by binding to CCR5. CCL3‐CCR5 axis facilitated COAD cell migration and invasiveness by activating the Akt signaling. CCL3 derived from both TAMs and cancer cells contributed to the malignant behaviors of COAD cells. High expression of CCL3/CCR5 was closely associated with poor prognoses of COAD patients.ConclusionCCL3‐CCR5 interaction promotes cell migration and invasiveness, and functions as a prognostic biomarker for COAD.
The soybean ubiquitin‐proteasome system: Current knowledge and future perspective
Authors: Xiong Erhui , Qu Xuelian , Li Junfeng , Liu Hongli , Ma Hui , Zhang Dan , Chu Shanshan , Jiao Yongqing 
Published: November 2022

AbstractIncreasing soybean [Glycine max (L.) Merr.] yield has become a worldwide scientific problem in the world. Many studies have shown that ubiquitination plays a key role in stress response and yield formation. In the UniProtKB database, 2,429 ubiquitin‐related proteins were predicted in soybean, however, <20 were studied. One key way to address this lack of progress in increasing soybean yield will be a deeper understanding of the ubiquitin‐proteasome system (UPS) in soybean. In this review, we summarized the current knowledge about soybean ubiquitin‐related proteins and discussed the method of combining phenotype, mutant library, transgenic system, genomics, and proteomics approaches to facilitate the exploration of the soybean UPS. We also proposed the strategy of applying the UPS in soybean improvement based on related studies in model plants. Our review will be helpful for soybean scientists to learn current research progress of the soybean UPS and further lay a theoretical reference for the molecular improvement of soybean in future research by use of this knowledge.
Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
Authors: Arshi Banafsheh , Chen Jinluan , Ikram M. Arfan , Zillikens M. Carola , Kavousi Maryam 
Published: November 2022

Abstract
Aims/hypothesis
The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluorescence (SAF), with prevalent heart failure, and with systolic and diastolic cardiac function, in a large population-based cohort study.

Methods
We assessed the cross-sectional association between SAF and prevalent heart failure among 2426 participants from the population-based Rotterdam Study, using logistic regression. Next, among individuals free of heart failure (N=2362), we examined the link between SAF (on a continuous scale) and echocardiographic parameters of left ventricular (LV) systolic and diastolic function using linear regressions. Analyses were adjusted for traditional cardiovascular risk factors.

Results
Higher levels of SAF were associated with higher odds of prevalent heart failure (multivariable adjusted OR 2.90 [95% CI 1.80, 4.62] for one unit higher SAF value). Among individuals without heart failure, one unit increase in SAF was associated with 0.98% lower LV ejection fraction (mean difference [β] −0.98% [95% CI −1.45%, −0.50%]). The association was stronger among participants with diabetes (β −1.84% [95% CI −3.10%, −0.58%] and β −0.78% [95% CI −1.29%, −0.27%] among participants with and without diabetes, respectively). Associations of SAF with diastolic function parameters were not apparent, except in men with diabetes.

Conclusions/interpretation
AGE accumulation was independently associated with prevalent heart failure. Among individuals free of heart failure, AGEs were associated with cardiac function, in particular systolic function. This association was present in participants with and without diabetes and was more prominent in those with diabetes.

Graphical abstract
Simultaneous profiling and quantification of 25 eicosanoids in human serum by ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry
Authors: Lu Yuanyuan , Mai Zhitong , Zhou Hongxia , Guan Wenda , Wu Shiguan , Zou Heyan , Shen Maoting , Zhan Yangqing , Ye Feng , Qiu Minshan , Shen Lihan , Zhao Beibei , Yang Zifeng 
Published: November 2022

AbstractThe eicosanoid metabolic pathway is responsible for mediating the production of various inflammatory factors that are closely related to the development and resolution of inflammation. In biological matrices, the major quantifying obstacles were shown to be the oxidation and low quantities of eicosanoids and their metabolites. This study aimed to develop a reliable, sensitive ultrahigh-performance liquid chromatography coupled to a tandem mass spectrometry (UPLC–MS/MS) method to quantify eicosanoids in human serum. Solid-phase extraction (SPE) was used for sample preparation. The approach employed continuous ionization polarity switching. The target eicosanoids showed good linearity over the investigated concentration range (r2 > 0.99). The recovery rates were over 64.5%, and the matrix effects ranged from 73.0 to 128.0%. The limits of quantification were 0.048 ~ 0.44 ng/mL. For the broad concentration range, the CV % for accuracy and precision were less than ± 20%. We successfully applied this method to rapidly analyse 74 serum samples from severe influenza pneumonia, severe bacterial pneumonia and healthy individuals. Eicosanoid-related metabolite concentrations were quantified within a range similar to those of previously published articles. Compared to healthy individuals, our application found that 20-HETE, 14,15-EET and 11,12-EET were upregulated in severe influenza pneumonia patients, while LTB4 was downregulated. 8-HETE and 5-HETE were upregulated in severe bacterial pneumonia patients, while LTE4 was downregulated. This approach provides a means for monitoring the low quantities of eicosanoids in biological matrices, and our finding that different characteristic metabolite profiles may help discriminate the induction of severe pneumonia patients.
Targeted α-therapy using astatine (211At)-labeled PSMA1, 5, and 6: a preclinical evaluation as a novel compound
Authors: Watabe Tadashi , Kaneda-Nakashima Kazuko , Shirakami Yoshifumi , Kadonaga Yuichiro , Ooe Kazuhiro , Wang Yang , Haba Hiromitsu , Toyoshima Atsushi , Cardinale Jens , Giesel Frederik L. , Tomiyama Noriyuki , Fukase Koichi 
Published: November 2022

Abstract
Purpose
Targeted α-therapy (TAT) for prostate-specific membrane antigen (PSMA) is a promising treatment for metastatic castration-resistant prostate cancer (CRPC). Astatine is an α-emitter (half-life=7.2 h) that can be produced by a 30-MeV cyclotron. This study evaluated the treatment effect of 211At-labeled PSMA compounds in mouse xenograft models.

Methods
Tumor xenograft models were established by subcutaneous transplantation of human prostate cancer cells (LNCaP) in NOD/SCID mouse. [211At]PSMA1, [211At]PSMA5, or [211At]PSMA6 was administered to LNCaP xenograft mice to evaluate biodistribution at 3 and 24 h. The treatment effect was evaluated by administering [211At]PSMA1 (0.40 ± 0.07 MBq), [211At]PSMA5 (0.39 ± 0.03 MBq), or saline. Histopathological evaluation was performed for the at-risk organs at 3 and 6 weeks after administration.

Results
[211At]PSMA5 resulted in higher tumor retention compared to [211At]PSMA1 and [211At]PSMA6 (30.6 ± 17.8, 12.4 ± 4.8, and 19.1 ± 4.5 %ID/g at 3 h versus 40.7 ± 2.6, 8.7 ± 3.5, and 18.1 ± 2.2%ID/g at 24 h, respectively), whereas kidney excretion was superior in [211At]PSMA1 compared to [211At]PSMA5 and [211At]PSMA6. An excellent treatment effect on tumor growth was observed after [211At]PSMA5 administration. [211At]PSMA1 also showed a substantial treatment effect; however, the tumor size was relatively larger compared to that with [211At]PSMA5. In the histopathological evaluation, regenerated tubules were detected in the kidneys at 3 and 6 weeks after the administration of [211At]PSMA5.

Conclusion
TAT using [211At]PSMA5 resulted in excellent tumor growth suppression with minimal side effects in the normal organs. [211At]PSMA5 should be considered a new possible TAT for metastatic CRPC, and translational prospective trials are warranted.
Validation and Meaningful Change Thresholds for an Objective Cough Frequency Measurement in Chronic Cough
Authors: Schelfhout Jonathan , Nguyen Allison Martin , Birring Surinder S. , Bacci Elizabeth D. , Vernon Margaret , Muccino David R. , La Rosa Carmen , Smith Jaclyn A. 
Published: November 2022

Abstract
Purpose
Objective cough frequency is used to assess efficacy of chronic cough (CC) treatments. The objective of this study was to explore the relationship between objective cough frequency and cough-specific patient-reported outcomes (PROs) and estimate a clinically meaningful change threshold (MCT) for objective cough frequency.

Methods
Data collected in a phase 2b study in participants with refractory or unexplained CC were used to investigate the relationship between 24-h cough frequency (measured using an ambulatory cough monitor) and cough-specific PROs (i.e., cough severity visual analog scale, cough severity diary, Leicester Cough Questionnaire). Convergent validity was assessed using Spearman ρ. An MCT for 24-h cough frequency was estimated using the patient global impression of change (PGIC) scale as an anchor.

Results
Correlations between 24-h cough frequency and cough-specific PROs at baseline, Week 4, and Week 12 were significant (P < 0.0001) but low to moderate in strength (ρ = 0.30–0.58). Participants categorized as very much improved/much improved (i.e., PGIC of 1 or 2) or minimally improved (i.e., PGIC of 3) had mean 24-h cough frequency reductions of 55% and 30%, respectively. Receiver operating characteristic curve analysis suggested that a 24-h cough frequency reduction of 38% optimizes sensitivity and specificity for predicting a PGIC score of 1–3.

Conclusion
Objective 24-h cough frequency is significantly associated with cough-specific PROs, but cough frequency and PROs most likely capture distinct aspects of CC. A ≥ 30% reduction in 24-h cough frequency is a reasonable MCT to define treatment response in CC clinical trials.
Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children
Authors: Zhong Xuhui , Ding Jie 
Published: November 2022

AbstractIgA nephropathy (IgAN) and IgA vasculitis-associated nephritis (IgAVN) are among the most frequent childhood glomerular diseases and are characterized by significant variability in clinical manifestations, pathological presentation and long-term outcomes. IgAVN, alternatively called purpura nephritis, is pathologically indistinguishable from kidney-limited IgAN. In Chinese children, the clinical presentations and pathological manifestations of IgAN and IgAVN are variable. The severity of proteinuria and abnormalities in kidney function and blood pressure of children in China are comparable to those of children in Europe, the USA, and Japan. Compared to Caucasian children and Japanese children, crescents were more common in Chinese children with IgAN or IgAVN. Approximately 10–20% of childhood IgAN or IgAVN progresses to impaired kidney function in China. Since 2007, a series of guidelines on the diagnosis and treatment of pediatric kidney diseases has been published following the principles of evidence-based medicine. However, a large difference exists between the Chinese evidence-based guidelines and the guidelines developed by Kidney Disease: Improving Global Outcomes (KDIGO) in 2021. Chinese children with IgAN or IgAVN were more likely to be treated with steroids or immunosuppressive agents. Further studies exploring the optimal treatment regimen for childhood IgAN or IgAVN are needed in the future.
Pyric Herbivory and the Nexus Between Forage, Fire and Native and Introduced Large Grazing Herbivores in Australian Tropical Savannas
Authors: Reid Angela M. , Murphy Brett P. , Vigilante Tom ,   Wunambal Gaambera Aboriginal Corporation, Bowman David M. J. S. 
Published: November 2022

AbstractEarth’s tropical savannas typically support high biomass of diverse grazing herbivores that depend on a highly fluctuating resource: high-quality forage. An annual wet–dry cycle, fire and herbivory combine to influence forage quality and availability throughout the year. In the savannas of northern Australia, a depauperate suite of large native (marsupial) herbivores (wallaroos [Osphranter spp.] and the agile wallaby [Notamacropus agilis]) compete for resources with non-native large herbivores introduced in the late nineteenth century, particularly bovines (feral and managed cattle [Bos spp.] and feral water buffalo [Bubalus bubalis]) that now dominate the landscape. Anecdotal reports of recent population declines of large macropods and negative impacts of bovines highlight the need to better understand the complex relationship between forage, fire and abundance of native and introduced large herbivores. The pyric herbivory conceptual model, which posits complex feedbacks between fire and herbivory and was developed outside Australia, predicts that native and introduced large herbivores will both respond positively to post-fire forage production in Australian savannas where they co-occur. We used grazing exclosures, forage biomass and nutrient analyses and motion-sensor camera-trapping to evaluate the overall robustness of the pyric herbivory model in the Australian context, specifically whether forage quantity and quality are impacted by herbivory, season and fire activity, and which forage attributes most influence large grazing herbivore abundance. Forage quantity, as measured by live, dead and total herbaceous biomass and proportion of biomass alive, was higher inside herbivore exclosures, even at relatively low densities of herbivores. Forage quality, as measured by fibre content, was not affected by herbivory, however, crude protein content of live herbaceous biomass was greater outside herbivore exclosures. Recent fire was an important predictor of all measures of forage quantity and quality. Recent fire occurrence decreased overall quantity (biomass) but increased quality (decreased fibre content and increased crude protein content); late dry season fires resulted in forage with the highest crude protein content. The predictions of the pyric herbivory conceptual model are consistent with observations of the feeding behaviour of introduced bovines and some large macropods in northern Australian savannas, lending support to the global generality of pyric herbivory in fire-prone grassy biomes.
High-resolution multi-parameter monitoring of microbial water quality and particles at two alpine karst springs as a basis for an early-warning system
Authors: Frank Simon , Fahrmeier Nikolai , Goeppert Nadine , Goldscheider Nico 
Published: November 2022

AbstractKarst aquifers are important resources for drinking water supply and are very vulnerable to contamination. Microbial concentrations at karst springs, in particular, often vary quickly over a short period of time. In this study, the response of microbial water quality and particle-size distribution of two alpine karst springs to rainfall events was investigated to test and validate parameters that can be used as early-warning systems for fecal contamination. At both investigated karst springs, total organic carbon, particle-size distribution (especially small particle fractions), and particle load show a good correlation to the fecal indicator bacteria E. coli and can therefore be used as a real-time indicator of fecal contamination at the investigated springs. In addition to conventional bacterial determination methods, the β-D-glucuronidase activity, which can be measured in near real-time, was used as a novel indicator parameter for fecal contamination. At the event scale, the β-D-glucuronidase (GLUC) activity shows a good correlation to E. coli and can be used as an additional real-time indicator of fecal contamination. For the studied springs, when they show two peaks in turbidity and small particles, these two parameters are suitable for an early warning system because the bacterial contamination occurs during the secondary peak of these parameters. These results highlight the vulnerability of karst aquifers and demonstrate the applicability of advanced measurement techniques in detecting fecal contamination in real-time, which is especially important given the time-consuming nature of conventional bacterial detection methods.
Investigating temporal and spatial patterns in the stochastic component of ZTD time series over Europe
Authors: Klos Anna , Bogusz Janusz , Pacione Rosa , Humphrey Vincent , Dobslaw Henryk 
Published: November 2022

AbstractThe EUREF Permanent GNSS Network (EPN) provides a unique atmospheric dataset over Europe in the form of Zenith Total Delay (ZTD) time series. These ZTD time series are estimated independently by different analysis centers, but a combined solution is also provided. Previous studies showed that changes in the processing strategy do not affect trends and seasonal amplitudes. However, its effect on the temporal and spatial variations of the stochastic component of ZTD time series has not yet been investigated. This study analyses the temporal and spatial correlations of the ZTD residuals obtained from four different datasets: one solution provided by ASI (Agenzia Spaziale Italiana Centro di Geodesia Spaziale, Italy), two solutions provided by GOP (Geodetic Observatory Pecny, Czech Republic), and one combined solution resulting from the EPN’s second reprocessing campaign. We find that the ZTD residuals obtained from the three individual solutions can be modeled using a first-order autoregressive stochastic process, which is less significant and must be completed by an additional white noise process in the combined solution. Although the combination procedure changes the temporal correlation in the ZTD residuals, it neither affects its spatial correlation structure nor its time-variability, for which an annual modulation is observed for stations up to 1,000 km apart. The main spatial patterns in the ZTD residuals also remain identical. Finally, we compare two GOP solutions, one of which only differs in the modeling of non-tidal atmospheric loading at the observation level, and conclude that its modeling has a negligible effect on ZTD values.
“Half a flood’s no good”: flooding, viticulture, and hydrosocial terroir in a South Australian wine region
Authors: Skinner William , Drew Georgina , Bardsley Douglas K. 
Published: November 2022

AbstractFloods generate both risks and benefits. In Langhorne Creek, South Australia, a historically-embedded system of shared floodwater management exists among farmers, who rely on semi-regular flood inundations as part of the region’s hydrosocial terroir – a dynamic conjunction of water, landscape, social relations and agricultural practice. Unruly floods coexist with a heavily regulated and precisely measured system of modern water management for viticultural irrigation across the region. Since the mid-twentieth century, groundwater extraction and new pipeline schemes have linked Langhorne Creek to the Murray Darling Basin water management system, which has displaced flooding as the primary source of irrigation water. The associated modernist shift towards the rationalization of water as a measurable resource has acted to sideline flood irrigation. Yet, floods maintain important viticultural, ecological and social roles in Langhorne Creek, adding to the flexibility and resilience of the region in response to water management challenges. The system involves technological and infrastructural components, such as flood gates and channels, but also relies upon the cooperation and coordination of community members. Local vignerons suggest that flood irrigation is environmentally as well as economically beneficial, rejuvenating riparian wetlands along watercourses. A more formal acknowledgement of the specific regional experiences of water management in a wine region like Langhorne Creek helps to fill a gap between emplaced and hydrosocial understandings of flood irrigation and broader assumptions about flooding as wasteful and inefficient.