bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose and insulin levels’ linkages with breast cancer factors
Authors: Mahashweta Das , Ishita Saha , Prasenjit Sinha , Sunit Kumar Medda , Rabindra Nath Das 
Published: April 2022

Serum lipid and glucose metabolisms are considered as the intermediary mechanisms for connecting obesity and Breast Cancer (BC). The article aims to identify the linkages between diabetes biochemical factors such as glucose & insulin and BC biochemical factors such as Monocyte Chemoattractant Protein-1 (MCP-1), adiponectin, Homeostasis Model Assessment score Insulin Resistance (HOMA-IR), resistin, leptin. These objectives can be focused on the two separate statistical models of glucose & insulin based on the remaining factors. From the mean model of glucose, it is observed that mean glucose level is directly linked with BC women (P= 0.023), leptin (P<0.001), HOMA-IR (P<0.001), while it is inversely linked with the interaction effects between HOMA-IR & leptin (i.e., HOMA-IR*leptin (P<0.001)) and adiponectin & leptin (i.e., adiponectin* leptin (P= 0.088)). Similarly, from the mean model of insulin, it is observed that mean insulin level is directly linked with HOMA-IR (P<0.001), leptin (P<0.001), and the interaction effects Age*MCP-1 (P= 0.091), glucose*adiponectin (P= 0.043), glucose*resistin (P<0.001), MCP-1*HOMA-IR (P<0.001), while it is reciprocally linked with MCP-1 (P= 0.026), resistin (P<0.001), adiponectin (P= 0.078), HOMA-IR*body mass index (BMI) (P<0.001), glucose*HOMA-IR (P<0.001), leptin*adiponectin (P= 0.071). There are more linkages of the variances of insulin and glucose with the BC biochemical factors. Based on the summarized results it is interpreted that diabetes biochemical factors such as insulin and glucose are highly linked with BC biomarkers such as MCP-1, HOMA-IR, leptin, resistin, and adiponectin.
Therapeutic Effects of Aloe vera (L.) Burm.f. and Vitis vinifera L. Combination Cream on Wound Healing in Second-Degree Burn Model in Rats: Quantiﬁcation of Compounds and VEGF & TGFβ Gene Expression
Authors: Moayeri Ardeshir , Ramz Kholoud , Karimi Elahe , Azizi Monireh , Abbasi Naser , Aidy Ali , Bahmani Mahmoud 
Published: April 2022

Finding more efficient agents with fewer side effects for the treatment of burns has been a concern for researchers. The current study aims to assess Aloe vera (L.) Burm.f. and Vitis vinifera L. extract combination (AVEC) effects on wound healing in rats compared with silver sulfadiazine (SSD). Identification of individual polyphenols of the plant extracts was performed by HPLC. The animals were randomly divided into twelve groups. Standard second-degree burn wounds were induced on the back. Groups were treated with Aloe vera (A.V) and Vitis vinifera (V.V) creams at concentrations of 0.5, 1, 1.5, and 2% with ED50 values of 1.5 ± 0.02 and 1.4 ± 0.08 %, respectively. The other group was treated with an AVEC cream (1.5%). The samples of burned skin tissue were collected from the rats for histopathological examination. To evaluate the expression of VEGF and TGFβ1, the real time-PCR method was used. Kaempferol was only detected in Aloe. This study revealed that AVEC cream exhibits significant wound healing activity. VEGF and TGFβ1 had a significant increase in the AVEC. Based on our findings, AVEC cream can be a therapy of choice for burn injuries.
Peran Pemerintah Kota Banjarmasin dalam Pengelolaan Lingkungan Hilir Sungai Barito – Kalimantan Selatan
Authors: Alviawati Eva , Angriani Parida 
Published: April 2022

Pengelolaan sungai memelukan sinergitas dari berbagai pihak. Pengelolaan sungai juga harus berkelanjutan dan dilakukan mulai dari hulu sampai ke hilir. Pemerintah dan masyarakat perlu saling bahu membahu dalam upaya pengelolaan sungai. Penelitian ini bertujuan untuk menganalisis peran pemerintah dalam pengelolaan lingkungan dan kondisi masyarakat hilir Sungai Barito. Metode yang dipergunakan dalam penelitian ini adalah kualitatif deskriptif. Data dalam penelitian ini berdasarkan hasil observasi lapangan dan pemanfataan data sekunder. Analisis data dilakukan secara deskriptif empirik. Hasil penelitian menunjukkan kegiatan pengelolaan sungai yang dilakukan oleh pemerintah antara lain melalui program perbaikan sungai seperti inventarisasi ulang dan labelisasi sungai, normalisasi sungai besar dan kecil, pembangunan dan pemeliharaan saluran drainase, revitalisasi dan penataan bantaran sungai, serta membangun fasilitas pendukung sungai lainnya. Selain pengelolaan secara fisik, program perbaikan sungai juga dilakukan pada aspek sosial ekonomi dan budaya masyarakat sekitar sungai, seperti melalui program PLPBK dan KOTAKU Kata Kunci: pengelolaan sungai, peran pemerintah, Sungai Barito
Un testimonio manuscrito de la primera edición del Corpus islamológico de Theodor Bibliander
Authors: González Muñoz Fernando 
Published: April 2022

El manuscrito Basel, Universitätsbibliothek A XIII 25 consiste en una suerte de borrador para la impresión de varias secciones del Corpus islamológico de Johannes Oporinus y Theodor Bibliander: Machumetis Saracenorum principis eiusque successorum vitae ac doctrina ipseque Alcoran, que fue publicado a inicios de 1543 en Basilea y reimpreso en 1550. Este estudio pretende destacar el interés de este documento, pues, por una parte, permite deja ver algunos aspectos del proceso editorial: correcciones, supresiones, errores de imprenta etc; por otra, aporta algunos textos ajenos al corpus, como son una lista fragmentaria de títulos latinos para las suras del Corán y una versión manuscrita del tratado de Theodor Bibliander: Ad nominis Christiani socios consultatio.
High-Detail Fault Segmentation: Deep Insight into the Anatomy of the 1983 Borah Peak Earthquake Rupture Zone (Mw 6.9, Idaho, USA)
Authors: Bello Simone , Andrenacci Carlo , Cirillo Daniele , Scott Chelsea P. , Brozzetti Francesco , Arrowsmith J Ramon , Lavecchia Giusy 
Published: April 2022

Abstract
Following observations made in a survey campaign along the Lost River Fault (Idaho, USA) in 2019, we integrate both original and previously published data to obtain a detailed segmentation of the fault sections that failed in the 1983 Borah Peak earthquake (Mw 6.9). The earthquake ruptured the topographic surface with an oblique-normal faulting mechanism, activating two SW-dipping fault segments (Thousand Springs and Warm Springs) and a branching SSW-dipping fault (Arentson Gulch Fault) and producing coseismic surface ruptures with up to 3 m of vertical separation. We augment the 1983 earthquake description by interpreting high-resolution topography and fault mapping. We use quality vertical separation data, rupture zone width measurements, and fault slip data to analyze major and minor structural-geometric complexities, highlighting a partition of the deformation and a fault segmentation into four detail levels (i.e., segments, sections, subsections, and sectors). Our work provides new details of the 1983 Borah Peak earthquake, constraints for paleoseismic and seismotectonic studies, and a methodological approach applicable in other areas of the world. Our fault-slip data show variations along fault-strike that we interpret as kinematic partitioning. In 1983, the main southern segment had a large rupture zone width, while the northern segment localized the deformation. The distributed ruptures accommodate a large portion of the rupture length (~19.5 km versus 31 km for the main rupture) and displacement (~66%). 83% of the surface faulting and 80% of the displacement are located at the hanging wall of the main rupture. There is a strong correlation between vertical separation, rupture zone width, rupture position (footwall or hanging wall), and fault geometry. We highlight the control of the obliquity and kinematic partitioning in the surface expression of the earthquake propagation. We interpret the coseismic (i.e., 1983) and long-term (i.e., Quaternary) behavior, showing that the two activated segments had similar cumulated behaviors in distributing the deformation between synthetic and antithetic ruptures, despite the different geometries. Our results have implications for fault rupture behavior with application to rupture hazard.
A Rare Complication of Closed Loop Obstruction With Mesenteric Volvulus Due to Jejunal Diverticulosis – A Case Report
Authors: Samy Angeline Mary , Subramaniyan Sree , Jain Ankit 
Published: April 2022

Abstract
Jejunal diverticulosis is a rare condition seen in 1-2% of the population and is asymptomatic in 80% of its patients. It can however rarely produce life threatening complications such as perforation, bleeding and obstruction. Diagnosis is often delayed in such patients causing high mortality. We report a 79 year old gentleman presenting with intestinal obstruction for 2 days with peritoneal signs. CT revealed jejunal dilatation with twisting of mesentery with whirlpool sign and closed loop obstruction of jejunum. A differential diagnosis of Jejunal diverticulosis should be considered when encountering patients in the elderly age group in an emergency setting.
Clinical value of serum CA125, CA724, HE4, premenopausal and postmenopausal ROMA index for diagnosis of high-grade serous ovarian cancer
Authors: Hu Deyu , Qian Jun , Yin Fenghua , Wei Bing , Hu Weiping , Wang Jiayu , Yang Haiou 
Published: April 2022

Abstract
Background: This study aimed at exploring a panel of novel biomarker for early detection of high-grade serous ovarian cancer (HGSOC). Methods: The serum levels of CA125, CA724 and HE4 were compared among serum samples collected from patients with HGSOC, borderline malignancy or benign gynecologic pathologies. Univariable and multivariable logistic regression analyses were performed to identify the risk factors of HGSOC. Nomogram was established for predicting HGSOC using the risk factors. Receiver operating characteristic (ROC) curves was plotted and the area under the curve (AUC), sensitivity and specificity of the CA125, CA724, HE4, ROMA and new panel were calculated.Results: The serum concentration of CA125, CA724 and HE4 were increased among patients with HGSOC. The AUC of CA125, CA724, HE4, ROMA2 and the new panel based on age, CA125 and ROMA2 were 0.732 (0.646-0.818), 0.773 (0.699-0.847), 0.886 (0.831-0.941), 0.835 (0.763-0.907), and 0.933 (0.896-0.969), respectively. Nomogram was constructed to diagnose HGSOC based on CA125, age and ROMA2. The C-indices of this nomogram was 0.88 (95% CI= 0.81-0.95) in training cohort and 0.91 (95% CI= 0.86-0.96) in the validation cohort. The sensitivity and specificity were 89.66% and 82.44% in diagnosing HGSOC, and the positive predictive value and negative predictive value of new algorithm were 69.33% and 94.74%, respectively.Conclusion: The new index based on age, CA125 and ROMA2 could be a new auxiliary diagnostic indicator in distinguishing HGSOC from borderline malignancy.
Nrf2 regulates microglia-mediated phagocytosis and neuroinflammation after intracerebral hemorrhage
Authors: Liu Lirong , Bao Shuangjin , Yao Zhenjia , Bai Qinqin , Liang Chuntian , Fu Pengcheng , Liu Xiangyu , Zhang John H. , Wang gaiqing 
Published: April 2022

Abstract
Activated microglia is essential for hematoma clearance and recovery after intracerebral hemorrhage (ICH). This study aims to evaluate the effect of microglial functional transformation in hematoma clearance after ICH. Through in vitro and in vivo experiments, we also investigate whether Nuclear factor erythroid 2-related factor 2 (Nrf2) -mediated microglial phagocytosis and inflammatory response plays a role in hematoma clearance and functional recovery after ICH. In vitro experiments, BV-2 cells were cultured and randomly divided into 4 groups, including normal control, microglia + Nrf2-siRNA (100 nmol/L), microglia + monascin (15 µM), and microglia + Xuezhikang (200 µg/mL) groups. In vivo experiments, 42 mice were divided into 2 groups, i.e., sham, ICH+vehicle, ICH+Nrf2-/-, ICH+monascin (10mg/kg/day, twice) and ICH+ Xuezhikang (0.2g/kg/day, twice) groups. Further, neurologic scores, hemoglobin levels, microglial phagocytosis, brain expression of CD80/Trem1/TNF-α (pro-inflammatory cytokines), and CD206/Trem2/ BDNF(anti-inflammatory cytokines) were analyzed 72 hours after surgery. The results showed that Nrf2 agonists improved neurological deficits and decreased hemoglobin levels after ICH through regulating microglial functional transformation. Administration of Nrf2 agonist- monascin/ Xuezhikang improved microglia-mediated phagocytosis of erythrocytes and bio-particles through Nrf2 upregulation. Alternatively, monascin/ Xuezhikang promoted the expression of Triggering receptor II expressed on myeloid cells(Trem2), CD206, and BDNF while inhibiting the expression of Trem1,CD80, and TNF-α in microglia. Conversely, Nrf2 inhibition (Nrf2 siRNA or Nrf2-/-) demonstrated conflicting results after ICH. Microglial functional transformations are implicated in hematoma clearance after ICH. Nrf2 activation leads to microglial functional transformation and phagocytic responses then exert its neuroprotection after ICH. Nrf2 activator (Monascin /Xuezhikang) improves hematoma clearance and alleviates neuroinflammation by regulating microglial functional alteration after ICH.
Arabinogalactan prevented APAP-induced acute liver injury by regulating the intestinal flora in mice
Authors: Wang Dongxu , Zhou Shengxue , Wang Xiuying 
Published: April 2022

Abstract
Background: This study aimed to explore the mechanism by which arabinogalactan (AG) inhibited N-acetyl-para-aminophenol (APAP)-induced acute liver injury in mice. The balance of the mouse intestinal flora and the relationship between AG treatment and the PI3K/AKT and NF-κB signaling pathways were evaluated to confirm a liver-gut interaction. Methods: Mice were administered 2 different doses of AG (150 or 300 mg/kg body weight) by gavage for 7 days and liver injury was induced by a single injection of APAP (250 m/kg). Hematoxylin-eosin staining, terminal deoxynucleotidyl transferase dUTP nick-end labeling, and Hoechst 33258 fluorescence staining of liver tissue were used to analyze liver damage. Western blots were used to evaluate expression of proteins related to PI3K/AKT and NF-κB signaling pathways, and changes in the hierarchical structure of the intestinal flora were determined. Results: AG pretreatment increased the proportion of Lactobacillus and decreased the abundance of species from norank_o_Clostridiaceae and Prevotella in mouse feces compared with APAP-only treated mice. AG pretreatment reversed glutathione depletion and CYP2E1 overexpression, reduced the production of malondialdehyde and 4-hydroxynonenal, and decreased the levels of alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-α and interleukin-1β compared with the APAP-only treated mice. The levels of proteins related to the PI3K/AKT signaling pathway were similar between the AG and control groups. AG pretreatment significantly reduced APAP-induced hepatocyte apoptosis and necrosis and inflammatory infiltration into the liver. Conclusion: PI3K/AKT pathway-mediated BAX expression and the NF-κB signaling cascade were inhibited by AG. AG protected the intestinal flora composition, which subsequently suppressed oxidative stress in the liver, improved the inflammatory response, and reduced hepatocyte apoptosis and necrosis.
Organisation, influence, and impact of patient advisory boards in rehabilitation institutions - an explorative cross-sectional study.
Authors: Sagen Joachim , Børøsund Elin , Simonsen Ann Elisabeth , Habberstad Andreas , Kjeken Ingvild , Dagfinrud Hanne Solveig , Moe Rikke Helene 
Published: April 2022

Abstract
Background: Patient participation is highlighted as an important facilitator for patient-centered care. Patient participation organised as patient advisory boards (PABs) is an integral part of health care institutions in Norway. More knowledge is needed on how PAB representatives experience patient engagement (PE) with regard to organisation, influence, and impact.Objectives: The objective of this study was to describe how PAB representatives engage in PABs with regard to tasks, roles, influence, and impact on decision-making processes and service delivery.Methods: PAB representatives recruited from rehabilitation institutions completed the Norwegian version of the generic Public and Patient Engagement evaluation tool (Norwegian abbreviation EBNOR). EBNOR is tested for reliability and validity with good results and comprises 35 items within four main domains, policies and practices, participatory culture, collaboration, and influence and impact that provide responses about PE-levels. Categorical data were summarized using frequencies and percentages, and response categories were collapsed into three PE-levels: barrier, intermediate, and facilitating level. Free-text responses were analysed according to principles of manifest content analysis, summed up, and used to elaborate the results of the scores.Results: Of the 150 contacted PAB representatives, 47 (32%) consented to participate. The results showed that approximately 75% agreed that the organisation as a whole was strengthened as a result of patient participation. Four out of five main domains were scored indicating a facilitating level; policies and practices (53%), participatory culture (53%), collaboration and common purpose (37%), and final thoughts (63%). The scores in the domain influence and impact were in the intermediate PE-level (44%). Of a total of 34 codes from free text analyses, barriers to PE were coded 26 times, and PE facilitators coded 8 times.Conclusions: The findings indicate that most PAB representatives are satisfied with how rehabilitation institutions organise their PAB, but they still experience their impact as limited.
The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis
Authors: Yin WeiWei , Huang Chang-Chang , Chen Yi-Ru , Yu Dan-Qing , Jin Min , Feng Chun 
Published: April 2022

Abstract
Objective: The study aims to address whether serum anti-müllerian hormone (AMH) levels fluctuate in the short term after medication application, including oral contraceptives (OCs), metformin, GnRH analogues (GnRH-a), dehydroepiandrosterone (DHEA), vitamin D (VD), clomiphene citrate (CC), and letrozole.Methods: Published literature from PubMed, Embase, and Cochrane central was retrieved up until 19 September 2021. A total of 51 self-control studies with an average Newcastle-Ottawa quality assessment scale (NOS) score of 6.90 were analyzed. Data collection and analysis: the extracted data were entered into Stata software, and the weighted mean difference/standardized mean difference (WMD/SMD) and 95% confidence interval (CI) were used for data analysis.Results: After OCs treatment the AMH level showed a significant decline in women with normal ovarian function, which was significant within 3 months (WMD=-1.43, 95% CI: -2.05 to -0.80, P<0.00001). After metformin treatment the serum AMH decreased in polycystic ovary syndrome (PCOS) patients (WMD=-1.79, 95% CI: -2.32 to -1.26, P<0.00001), in both obese and non-obese patients. GnRH-a treatment in endometriosis patients led to dynamic changes in the serum AMH levels. that is, ascent at 1 month(P=0.05), and descent at 3 months (P=0.02). After DHEA treatment the serum AMH increased in diminished ovarian reserve (DOR) / poor ovarian response (POR) patients (WMD=0.18, 95% CI: 0.09 to 0.27, P<0.0001). After VD treatment the serum AMH increased, and it was obvious in non-PCOS patients (WMD=0.78, 95% CI: 0.34 to 1.21, P=0.0004). After CC treatment the serum AMH decreased significantly in PCOS patients, specifically in non-obese patients (WMD=-1.24, 95% CI: -1.87 to -0.61, P=0.0001). Conclusions: Serum AMH levels may be affected in the short term after drug application. Specifically, OC, metformin and CC leads to decreased AMH level, DHEA and VD leads to increased AMH level, and GnRH-a leads to dynamic variation, which is correlated with PCOS, obesity, age, and duration of medication. The impacts of these medication should be taken into consideration when AMH is used as a marker of ovarian reserve.
Probing the solar coronal magnetic field with physics-informed neural networks
Authors: Jarolim Robert , Thalmann Julia , Veronig Astrid , Podladchikova Tatiana 
Published: April 2022

Abstract
While the photospheric magnetic field of our Sun is routinely measured, its extent into the upper atmosphere remains elusive.
We present a novel approach for coronal magnetic field extrapolation, using a neural network that integrates observational data and the physical force-free magnetic field model. Our method flexibly finds a trade-off between the observation and force-free magnetic field assumption, improving the understanding of the connection between the observation and the underlying physics.
We utilize meta-learning concepts to simulate the evolution of active region NOAA 11158. Our simulation of 5 days of observations at full cadence, requires less than 13 hours of total computation time, enabling real-time force-free magnetic field extrapolations.
A systematic comparison of the time evolution of free magnetic energy and magnetic helicity in the coronal volume, as well as comparison to EUV observations demonstrates the validity of our approach. The obtained temporal and spatial depletion of free magnetic energy unambiguously relates to the observed flare activity.
Assessment of aquifer geometry and groundwater storage using three-dimensional hydrostratigraphic modeling and geophysical survey: The case study of Nefza massive dunes (Northern Tunisia)
Authors: Jerbi Hamza , Sebai Amal , Hamlaoui Ikram , Hamdi Mohamed , Hmida Nesrine 
Published: April 2022

Abstract
The aquifer system of Nefza in northern Tunisia has been exploited for decades in its southern part to meet the increasing need for drinking water. The drop in groundwater levels observed since the 1980s in this exploited area has led water resource managers to focus on the depletion of the groundwater resource, while the availability of groundwater in the entire aquifer system is not well known. To date, the total amount of groundwater stored in the aquifer system has never been fully estimated. That is the purpose of this paper. The methodology includes (1) creating a comprehensive database combining all available lithological and geophysical data (2) designing a three-dimensional model of the aquifer system (3) incorporating hydrodynamic parameters into the model to estimate groundwater storage. The developed model illustrates the spatial distribution of groundwater storage, improves mapping of aquifer geometry, and delineates major aquifers and aquitards. Over 45 km2 of the modeled area, the calculated groundwater storage in 2019 was approximately 3 × 109 m3 with a highly variable spatial distribution. It was found that the area currently exploited for drinking water supply represents low groundwater storage between 97 and 377 m3/voxel (voxel size =1000 m x 1000 m x 5 m) while the unexploited area has excellent groundwater storage up to 798 m3/voxel. Furthermore, over the past 52 years (1976-2019), only 0.2% of the groundwater storage in the aquifer has been depleted. This paper suggests that water management challenges should focus on accessing non-exploited areas of the aquifer covered by forests, even though the cost of the land development and the installation of water pipelines is burdensome. In addition, the water balance of the aquifer is poorly known and groundwater flow in this region needs to be better assessed by multiple methods such as geochemistry and hydrodynamic modeling.