bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurse-driven intranasal dexmedetomidine administration as sedation for non-invasive procedures in children: a single center audit.
Authors: Goyens Emma , Allegaert Karel , Debuck Frederik , Lauweryns Julie , Toelen Jaan , Vanhonsebrouck Koen 
Published: September 2022

AbstractPurpose To audit the efficacy and safety of intranasal dexmedetomidine sedation for non-invasive procedural sedation in children provided by nurses of the procedural sedation (PROSA) team in the University Hospitals Leuven. Efficacy (successful sedation as sole sedative) and safety (cardiorespiratory monitoring, saturation) were hereby assessed. Methods In this audit, prospectively recorded data were extracted from the medical files in 772 patients between 4 weeks to 18 years old, who underwent sedation with intranasal dexmedetomidine (2–4 µg/kg) by the nurse-driven PROSA team. Results 90.7% of the patients were successfully sedated (single dose, monotherapy), 60 patients (7.8%) needed an additional intervention during sedation, of whom 37 (4.8%) needed an extra dose of intranasal dexmedetomidine and 14 (1.8%) received an additional other sedative. Successful sedation rates were higher in younger children, and medical imaging was the most common indication. Sedation failed in 12 (1.6%) patients, with 10 of them failed to fall asleep. Adverse events were limited in number (n = 13, 1.7%) and severity: 4 patients had a low heart rate (one treated with atropine), one had an irregular heart rate, and 7 desaturation events were described. Hypotension was treated with normal saline in one case. Conclusions In this nurse-driven PROSA setting, intranasal dexmedetomidine is effective and safe for non-invasive procedural sedation in paediatric patients.
Sunitinib in patients with favorable and intermediate risk metastatic renal cell carcinoma – Lithuanian National Cancer Institute experience
Authors: Zalimas Algirdas , Urbonas Vincas , Dabkeviciene Daiva , Purvaneckas Jonas , Ulys Albertas , Jarmalaite Sonata 
Published: September 2022

Abstract
Introduction and Objectives
Sunitinib, according to the European Society for Medical Oncology (ESMO) and National Comprehensive Cancer Network (NCCN) recommendations, is one of the recommended regimens for favorable and intermediate risk metastatic renal cell carcinoma (mRCC) patients. Our objective was to evaluate sunitinib efficacy as a first-line treatment for mRCC patients with favorable / intermediate prognostic risk in a real-world setting.
Materials and Methods
Patients with diagnosed mRCC and confirmed as appropriate candidates for the first-line systemic treatment were included in the retrospective study. The prognostic risk was evaluated according to the model of International Metastatic RCC Database Consortium (IMDC). Patients received sunitinib as a first-line treatment.
Results
A total of 94 patients were enrolled from 2019 to the 2020 year. 67 patients were included for the detailed analysis. The median age at diagnosis was 62 years. Majority of patients had clear cell renal carcinoma with prior nephrectomy. Half of patients had more than 3 metastatic sites. Metastasectomy was performed for one third of the patients. Median progression-free survival (PFS) was 23.4 (95% CI: 17.3-29.5), and median overall survival (OS) was 66 months (95% CI: 44.9-87.1). The age over 60 years was significant negative predictor for PFS and OS. Regarding IMDC model for disease risk prediction, the number of two risk factors in the intermediate risk group was a significant predictor for a shorter response to the first-line therapy.
Conclusion
In everyday clinical practice, sunitinib is an effective systemic therapy for favorable/intermediate risk groups mRCC patients. This tyrosine kinase inhibitor (TKI) can be used as a first-line treatment in this group of patients, especially in countries where novel systemic treatment modalities are not available yet.
TGF-β signaling and N6-methyladenosine with ciRs-7 in cervical cancer metastasis
Authors: Zhong Guanglei , Wang Yuhan , Zhou Haijian , Fu Zhaojie , Chen Zhiliao , Yao Tingting 
Published: September 2022

Abstract
Background
Circular RNAs (circRNA) are a group of influential regulators associated with cancergenesis. However, there has been no report in cervical cancer on ciR-7.
Results
In situ hybridization showed ciRs-7 was upregulated and positively correlated with lymph node metastasis and worse overall survival. In addition, overexpression of ciRs-7 promoted cervical cancer metastasis in vitro and in vivo. It was also found that ciRs-7 could promote the orchestration of IGF2BP1 on the mRNA of SLUG and stabilize it from degradation. Silencing IGF2BP1 could promote cervical cancer metastasis. Additionally, effective ciRs-7 has been proven to activate TGF-β signaling factors known to promote EMT, including p-smad2 and p-smad3. Effective ciRs-7 in cervical cancer promotes metastasis via activating TGF-beta induced EMT and stabilizing SLUG expression through working as a scaffold between IGF2BP1 and SLUG mRNA.
Conclusions
Our study for the first time proved the potential role of ciRs-7 in mediating progression of cervical cancer.
Psychosocial and Mental Health Difficulties among Adolescents with Body Image Dissatisfaction
Authors: Medise Bernie Endyarni , Nasution Kholisah , Devaera Yoga , Prayitno Ari , Djer Mulyadi M , Ifran Evita Karianni Bermanshah , Iskandar Adhi Teguh Perma 
Published: September 2022

Abstract

Background:Adolescents’ psychosocial and mental health is affected by body image. However, adolescent body image dissatisfaction (BID) is noted as an epidemic problem worldwide and limited studies in developing countries were performed. This study aimed to assess the association between psychosocial-mental health difficulties and BID among adolescents in Indonesia.Methods:We conducted a cross-sectional study in high schools in Jakarta selected by cluster random sampling. The randomly selected students aged 14-18 from each school were provided with online questionnaires, including Body Dissatisfaction Scale (BDS), Strength and Difficulties Questionnaire (SDQ), and Kessler Psychological Distress Scale (KPDS).Results:There were 327 subjects who filled out the questionnaire completely and were included in the analysis. The common psychosocial and mental health difficulties in adolescents in this study were hyperactivity-inattention, peer problems, and emotional problems (30%, 20.8%, and 20.2% consecutively). The overall psychosocial and mental health scores were not statistically higher in the BID group, but the emotional symptom scores were significantly higher in the BID group (p=0.023). The correlation between stress level and emotional symptom scores is also strong (p<0.001, r=0.701).Conclusion:Public health interventions are needed to assist adolescents to improve their body confidence and develop a resistant coping mechanism.
Comparison between two different expansion protocols in early mixed dentition:Clear Aligners vs Rapid Maxillary Expansion
Authors: Lombardo Elisabetta Cretella , Fanelli Silvia , Paoloni Valeria , Cozza Paola , Lione Roberta 
Published: September 2022

Abstract
Background: to compare the effects of two different expansion protocols in terms of bi-dimensional linear, angular measurements, and three-dimensional analysis of palatal area on digital casts in patients with mixed dentition.
Methods: digital casts of 32 children treated with the RME (RG: 17 subjects), or with clear aligners (FG: 15 subjects) were collected. Linear and angular values were measured in both groups on the upper arch for each pre (T1) and post-treatment (T2) models, as well as palatal area. Unpaired t-test was used to test significant differences between groups (p<0.05).
Results: the comparison of T2-T1 changes for linear measurements between groups showed significant differences in the inter-canine width (+1.5mm in FG), in the first inter-deciduous molar width (+1.5mm in FG), in the first inter-molar distal width (-1.2mm in FG), in the inter-canine transpalatal width (+1.5mm in FG) and in the first inter-deciduous molar transpalatal width (+1.4mm in FG). The analysis of angular measurements showed a significant increase of the crown angulation for all the teeth in FG except for the second deciduous molars and for the first molars. First molars showed a reduction of this parameter. FG patients showed a greater increase of the palatal area.
Conclusions: the comparison between FG and RG groups pointed out that clear aligners system seems to be more efficient than RME in terms of expansion obtainable at the anterior segment of the arch with a better control of upper first molar crown angulation and a greater increase of the palatal area.
Fungal cell barriers and organelles are disrupted by Polyhexamethylene biguanide (PHMB)
Authors: Ntow-Boahene Winnie , Papandronicou Isabelle , Miculob Josephous , Good Liam 
Published: September 2022

Abstract
The similarities between fungal and mammalian cells pose inherent challenges for the development of treatments for fungal infections, due to drug crossover recognition of host drug targets by antifungal agents. Thus, there are a limited number of drug classes available for treatment. Treatment is further limited by the acquisition and dissemination of antifungal resistance which contributes to the urgent need of new therapies. Polyhexamethylene biguanide (PHMB) is a cationic antimicrobial polymer with bactericidal, parasiticidal and fungicidal activities. The antifungal mechanism of action appears to involve preferential mechanical disruption of microbial cell structures, offering an alternative to conventional antifungals. However, the antifungal mechanisms have been little studied. The aim of this study was to characterise PHMB’s activities on selected yeast (S. cerevisiae, C. albicans) and filamentous (F. oxysporum, P. glabrum) fungal species. Fungal membrane disruption, cell entry and intracellular localisation activities of PHMB were evaluated using viability probe entry and polymer localisation studies. We observed that PHMB initially permeabilises fungal cell membranes and then accumulates within the cytosol. Once in the cytosol, it disrupts the nuclear membrane, leading to DNA binding and fragmentation. The electrostatic interaction of PHMB with membranes suggests other intracellular organelles could be potential targets of its action. Overall, the results indicate multiple antifungal mechanisms, which may help to explain its broad-spectrum efficacy. A better understanding of PHMB’s mechanism(s) of action may aid the development of improved antifungal treatment strategies.
Cinnamic aldehyde induces apoptosis of breast cancer cells via STAT3/cMyc pathway
Authors: Yi Xiaohong , Hou Lefeng , Tan Xue , Pei Tianli , Li Shengrong , Huang Lijun 
Published: September 2022

Abstract
Signal transducer and activator of transcription 3 (STAT3) is known to be activated in numerous cancer types, including more than 40% of breast cancers. STAT3 ’s downstream gene cMyc serves as an important target in cancer treatment. However, the clinical availability of small-molecule inhibitors that can target cMyc are lacking.Cinnamic aldehyde (CA) has been reported to inhibit the proliferation of a variety of cancer cells, including those in breast cancer; however, its molecular mechanism remains unclear. This study examined CA induction of apoptosis in breast cancer cells via STAT3/cMyc pathway. The corresponding findings demonstrated that CA significantly inhibited the proliferation and migration of MDA-MB-231 cells, MCF-7 cells, and 4T1 cells in both a time and concentration-dependent manner. CA was also shown to enhance the effect of cMyc inhibitor 10074-G5 and was observed to be better than 10074-G5 in the same concentration. CA also inhibited the proliferation and migration of breast cancer cells, which may be related to the induction of breast cancer cells’ mitochondral apoptosis through the down-regulation of apoptosis-related proteins via STAT3/cMyc pathway. Accordingly, this study suggests that CA may serve as a novel cMyc inhibitor in breast cancer cells and should be further studied.
Enhancement the Nutritional Quality of Pretzels Using Sprouted Garden Cress
Authors: Gebreil Seham , Mahdy Samar , Asal Mostafa 
Published: September 2022

Abstract
The purpose of this paper is to enhance the nutritional quality of pretzels using sprouted garden cress seeds. Sprouting was performed in garden cress seeds at 3and 6 days to select the best sprouting conditions. Chemical composition, total phenols, flavonoids, and DPPH were performed on sprouted and un-sprouted garden cress. Sprouted and un-sprouted garden cress seeds were substituted at 0, 5, 10, and, 15% level with wheat flour in pretzels preparation. Chemical analysis, sensory properties and protein quality were performed on pretzels to assess its nutritional quality. After 3& 6 days, sprouting increased (P ≤ 0.05) ash (9.89, 5.88%), fiber (10.20, 8.61%), and protein (24.71, 25.92%). Sensory scores showed no (P ≤ 0.05) differences between pretzels with sprouted and un-sprouted garden cress at 5 and 10% for all attributes. Pretzels with 10% sprouted garden cress was the highest (P ≤ 0.05) of Zinc (20.1), iron (67.05), magnesium (494), calcium (1503), potassium (2885) and phosphorus (328 and 48mg/100g). In vitro protein digestibility (78.46%), total essential amino acids (3.8), total non-essential amino acids (4.8%) were increased in pretzels with 10% sprouted garden cress compared to un-sprouted seeds. Sprouted garden cress could be used to improve the nutritional quality of pretzels at 10% level of substitution with wheat flour with highly acceptability.This study leads to valuable addition and improvement of consumers diet, especially with the exploration of the potential of sprouted garden cress seed in a popular bakery snack like pretzels was very limited.
An epigenetic mechanism for differential maturation of amygdala-prefrontal connectivity in childhood socio-emotional development
Authors: Morris James , Skyberg Amalia , Newman Benjamin , Graves Andrew , Goldstein Alison , Brindley Samantha , Kim Minah , Druzgal T. , Connelly Jessica 
Published: September 2022

Abstract
Functional connectivity between the amygdala and the medial prefrontal cortex (mPFC) has been identified as a neural substrate of emotion regulation that undergoes changes throughout development. Amygdala-mPFC connectivity has been well studied in adolescents and adults, with a mature profile typically emerging at 10 years of age. Maternal bonding in childhood has been shown to buffer amygdala reactivity and to influence the trajectory of amygdala-mPFC coupling, which in turn may impact socio-emotional dysfunction later in life. The oxytocinergic system is critical in the development of social behavior and maternal bonding. Early life parental care influences the methylation status of the oxytocin receptor (OXTRm) in animal models and humans, and higher OXTRm is associated with lower amygdala-PFC functional connectivity in adults. Using a neuroimaging-epigenetic approach, we investigated OXTRm as a biological marker of functional connectivity maturation in middle childhood. We find that higher levels of OXTRm are associated with a more adult-like functional connectivity profile. We also find that lower OXTRm blunts the association between amygdala-mPFC connectivity and future internalizing behaviors in early adolescence. These findings implicate OXTRm as a biological marker at the interface of the social environment and amygdala-mPFC coupling in emotional and behavioral regulation. Ultimately, identification of neurobiological markers may lead to earlier detection of children at risk for socio-emotional dysfunction.
Gain variations as induced by the diffuse night sky background: the ASTRI-Horn experience
Authors: Impiombato Domenico , Compagnino Antonio Alessio , Mineo Teresa , Catalano Osvaldo , Giarrusso Salvatore , Maccarone Maria Concetta 
Published: September 2022

Abstract
ASTRI-Horn is the prototype of the nine telescopes that form the ASTRI Mini-Array, under construction at the Teide Observatory in Spain, devoted to observe the sky above 10 TeV. It adopts an innovative optical design based on a dual-mirror Schwarzschild-Couder configuration, and the camera, composed by a matrix of monolithic multipixel silicon photomultipliers (SiPMs) is managed by ad-hoc tailored front-end electronics based on a peak-detector operation mode. During the Crab Nebula campaign in 2018-2019, ASTRI-Horn was affected by gain variations induced by high levels of night sky background. This paper reports the work performed to detect and quantify the effects of these gain variations in shower images. The analysis requested the use of simultaneous observations of the night sky background flux in the wavelength band 300-650 nm performed with the auxiliary instrument UVscope, a calibrated multi-anode photomultiplier working in single counting mode. As results, a maximum gain reduction of 15% was obtained, in agreement with the value previously computed from the variance of the background level in each image. This ASTRI-Horn gain reduction was caused by current limitation of the voltage supply. The analysis presented in this paper provides a method to evaluate possible variations in the nominal response of SiPMs when scientific observations are performed in the presence of high night sky background as in dark or gray conditions.
Effect of welding heat input conditions on the dynamic behavior of pulse laser beam welding molten pool for Ti6Al4V thin plate with clearance
Authors: Kong Bin , Wei Yanhong , Tang Fengye , Chang Yiting , Chen Jicheng 
Published: September 2022

Abstract
For a practical pulse laser beam welding (PLBW) process of metal sheets assembled in butt joint configuration, the precise control of the assembling clearance has been a challenge. The existence of machining burrs and assembly errors will lead to forming severe defects, such as misalignment, welding leakage, and penetrating. In this paper, a pair of Ti6Al4V plates with a 0.2 mm air gap was tested by an improved PLBW process. A three-dimensional multi-phase and multi-physical field coupling model of Ti6Al4V alloy plate with a reserved air gap was established according to the weld profile, and the dynamic behavior of the keyhole and molten pool was simulated. Transient temperature field, velocity field, keyhole size, and liquid bridge connection were calculated by using different welding heat input parameters. The results showed that the weld profile simulated by the CFD model is in good agreement with the experimental results, and the deviation is between 0.68% and 7.95%. After the laser power reaches the peak value, the metal steam eruption weakens and the obvious Marangoni vortex appears in the molten pool. The simulated keyhole is always in three stages, that is, the keyhole appears, and then gradually forms the through-hole. The through hole keeps oscillating, and finally, the keyhole shrinks and disappears when the laser power drops to zero. With the increase of laser peak power, the keyhole shape becomes more curved, indicating that the keyhole oscillation is enhanced. With the increase in welding speed, the stability of the molten pool is improved, and the area of the liquid bridge rises more regularly.
Dipeptidyl peptidase-4 inhibitors and mortality risks in patients with prostate cancer receiving androgen deprivation therapy: a population-based cohort study
Authors: Hui Jeremy , Lee Yan Hiu Athena , Li Simon , Liu Kang , Dee Edward , Ng Kenrick , Chan Jeffrey , Tse Gary , Ng Chi Fai 
Published: September 2022

AbstractBackground Dipeptidyl peptidase-4 inhibitors (DPP-4I) have demonstrated survival benefit in patients with cancer, but their impact on patients with prostate cancer (PCa), especially with androgen deprivation therapy (ADT), is unclear. This study examined the impact of DPP-4I use on mortality risks in patients with type 2 diabetes (T2D) and PCa receiving ADT. Methods Adults with T2D and PCa who received metformin and ADT attending public hospitals in Hong Kong between 1 January 2006 and 31 March 2021 were retrospectively identified. Patients with < 6 months of chemical castration without bilateral orchidectomy, < 6 months of concurrent DPP-4I and ADT use, or missing baseline HbA1c were excluded. DPP-4I users had ≥ 6 months of concurrent DPP-4I and ADT use, while non-users never had DPP-4I use. Included patients were followed-up until 30 September 2021. The endpoints were PCa-specific mortality and all-cause mortality. Inverse probability treatment weighting was used to balance covariates. Results In total, 1465 patients (286 DPP-4I users and 1179 non-users; mean age 76.0 ± 7.9 years old) were analyzed. Over a mean follow-up of 4.0 ± 3.0 years, DPP-4I users had lower risks of PCa-specific mortality (weighted hazard ratio (wHR) 0.40 [95% confidence interval (CI) 0.26–0.59], p < 0.001) and all-cause mortality (wHR 0.59 [95% CI 0.48–0.73], p < 0.001). Such associations were independent of diabetic control. Moreover, the association between DPP-4I use and risks of PCa-specific mortality was independent of chemotherapy or androgen receptor signaling inhibitor use. Conclusions DPP-4I use is associated with decreased mortality risks in patients with T2D and PCa receiving ADT.
Early-Stage Breast Cancer Menopausal Symptom Experience and Management: Exploring Medical Oncology Clinic Visit Conversations Through Qualitative Analysis
Authors: Limbacher Sarah A. , Mazanec Susan R. , Frame Jennifer M. , Connolly Mary C. , Park Sumin , Rozenzweig Margaret Q. 
Published: September 2022

Abstract
Purpose
Women being treated with chemotherapy for breast cancer experience menopausal symptoms that vary in presentation and impact on quality of life. The clinical visit before each chemotherapy cycle provides an important opportunity to allow patients to dialogue with their medical oncology healthcare providers about these symptoms and identify strategies for self-management. The objective of this study was to characterize patient and provider interactions regarding the menopausal symptom experience and management in the context of breast cancer treatment.
Methods
Thematic analysis was employed to analyze 61 transcripts from clinical encounters of women receiving chemotherapy treatment for breast cancer. Transcripts were chosen based on their inclusion of menopausal symptom discussion.
Results
Themes were separated into three distinct categories: patient, clinician, and dyadic themes. The overarching theme was goal discordance in the clinical visit, which was reflected in the following themes: unexpected & unprepared, distressed, disrupted & disturbed, clinical insensitivity, missed opportunity for management and empathy, and use of humor and colloquial language. Overall, women were unprepared for the menopausal symptom experience and clinicians did not often provide management, interventions, or empathetic responses.
Conclusion
There is a need to develop more astute assessment and communication regarding menopausal symptoms during the clinical visit. Possible interventions include a more holistic assessment, algorithms to facilitate the clinician’s attention and response to menopausal symptoms, and treatment of symptoms.