bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of SOX10 and estrogen receptor immunohistochemical expression in endometrial carcinoma of Egyptian patients
Authors: Kora Mona A. , Moselhy Alyaa A. , Abdallah Rania A. 
Published: February 2025

Background
A critical need for new therapeutic targets and more precise markers of endometrial carcinoma (EC) is required, particularly for metastatic and recurrent cases. The purpose of this work is to examine the utility of SOX10 expression in EC. In addition, we looked at estrogen receptor (ER) expression in EC and examined its correlation with clinicopathologic variables.

Patients and methods
This retrospective study included 108 EC hysterectomy specimens from Egyptian patients. Immunohistochemical staining for SOX10 and ER was performed using the streptavidin–biotin–peroxidase technique. The results were correlated with clinicopathologic parameters together with overall (OS) and recurrence-free survival.

Results
Surprisingly, SOX10 expression appeared negative in all studied EC patients. Positive ER expression was noticed in 67 (62%) cases that was closely linked to negative nodal metastasis, M0 stage, early-stage group, absence of recurrence, type I EC, and low-grade tumors. A complete response to therapy was significantly correlated with increased ER total percentage and H-score of expression. Endometrial cancer patients with early-stage diseases (T1, N0, and M0), no recurrence, type I EC, less than or equal to 50% myometrial invasion, absence of necrosis, adjacent hyperplastic endometrium, complete response to therapy, and positive ER expression exhibited better OS rates. In addition, longer recurrence-free survival was associated with cases exhibiting strong ER-dominant intensity.

Conclusion
ER expression in EC was correlated with a number of favorable prognostic parameters, better OS, and a complete response to therapy. These findings are therapeutically important because ER loss may help to distinguish high-risk patients for accurate personalized treatment. Moreover, the fact that SOX10 was negatively expressed in all studied cases indicated that it had no impact either on initiation or progression of EC.
Prevalence of Allergies in Children with Idiopathic Nephrotic Syndrome
Authors: Khanna Alok , Kharkongor Nancy P. , Verma Anjali , Bhalla Kapil , Gill Paramjeet S. , Verma Surender , Prakash Gulshan 
Published: February 2025

ABSTRACT

Introduction:
Nephrotic syndrome (NS) is a common chronic kidney disease in children characterized by the leakage of protein through a pathologically altered glomerular filtration membrane. There is not much literature on a clear association between Idiopathic Nephrotic Syndrome (INS) and atopic disorder and the relationship between IgE and IL-13 in children with INS in relapse and remission. Thus, the present case-control study was conducted using the validated assessment tool i.e., the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to determine the prevalence of allergies along with the estimation of IgE and IL-13 levels to determine their role in the pathogenesis and outcome of patients with NS.

Methods:
The present study was a hospital-based, case-control study, which was conducted in the Department of Paediatrics, Pt. B.D. Sharma PGIMS, Rohtak to determine the prevalence of allergies in children with Idiopathic NS. Fifty children with NS (Group I) were taken as cases and 50 age and gender-matched children (Group II) were taken as controls. Allergies were assessed by using the ISAAC Questionnaire, and IgE and IL -13 were determined by the ELISA technique.

Results:
Baseline demographics were comparable in both groups. The incidence of asthma was higher in Group I as compared to Group II and statistically significant. The mean serum IgE and IL -13 levels in Group I were higher as compared to Group II, and the difference was statistically significant, P value being <0.001. There was a moderate positive correlation between Serum IL-13 and Serum IgE (IU/ml). The incidence of rhinitis and eczema was also higher in Group I as compared to Group II; however, it was not statistically significant.

Conclusion:
Allergic conditions were frequently found in children with INS. Increased IgE and IL-13 may reflect the activation of an immune mechanism following various stimuli, which is ultimately a reflection of immune dysregulation, and it may have a role in the pathogenesis of INS.
Development and Evaluation of Effectiveness of a Universal Behavior Change Communication (UBCC) Model
Authors: Mukherjee Abhishek , Gupta Avantika , Patel Geeta , Kosambiya JK 
Published: February 2025

ABSTRACT

Background:
Universal Behavior Change Communication (UBCC) is a comprehensive communication model, with participant-centric messages, applicable to varied social and clinical pathologies.

Objective:
To develop and evaluate the effectiveness of the UBCC model.

Methodology:
A multiphase mixed-method study from June 2022 to July 2023. Phase I and III were conducted in urban field practice areas, where two Galis each were selected using simple random sampling. Phase II was conducted in urban and rural using systematic random sampling for household selection. Data were collected by face-to-face interviews. Basic communication framework was developed in Phase I using comprehension and retention analysis on “Anemia Mukt Bharat.” Model content and implementation processes were finalized in Phase II, targeting parental coronavirus disease 2019 (COVID-19) vaccine hesitancy. Effectiveness was evaluated in Phase III by extrapolating the model to other health issues, where reliability and validity were assessed. Binary logistic regression and Chi-square tests were applied for analysis.

Results:
In Phase I, participants had higher odds of retaining subdomains of perceived susceptibility (aOR = 5.7, P < 0.001), perceived severity (aOR = 1.8, P = 0.02), perceived benefits (aOR = 7.5, P < 0.001) and convenience (aOR = 3.8, P = 0.003). The Ebbinghaus retention curve showed higher residual knowledge in the group where repetition was done. The addition of regional statistics in Phase II had higher vaccine acceptance (P = 0.001). The choice of implementer (P = 0.377) and place of implementation (P = 0.099) showed no significant difference. Phase III demonstrated positive behavior change in “cloth washing practices” (P = 0.003) and “footwear practice” (P = 0.001). The model had good internal consistency (Cronbach’s α =0.893), substantial test-retest reliability (ICC = 0.69-0.78), and satisfactory content validity index (0.94).

Conclusion:
There is a need to apply resource-saving UBCC model with high validity and reliability, across various levels of health care system.
Assessment of Quality of Life in Cervical Cancer Patients at a Tertiary Care Centre
Authors: Keerthana Koppolu , Subhaprada Savolu Cynthia 
Published: February 2025

ABSTRACT

Background:
Cervical cancer is the fourth most common neoplasm among women. Cancer and treatment side effects have adverse effects and this affects patient’s well-being during and after treatment, resulting in lower quality of life (QoL). The paucity of data about QoL of Indian cervical cancer survivors led to the present study with the objective of assessing quality of life among cervical cancer patients.

Methodology:
A cross-sectional study was conducted among 136 cervical cancer patients attending Gynecology Out Patient Department (OPD) and Radiotherapy OPD, in Government General Hospital, Kurnool, during April–May 2023. Sample size was calculated using Cochran’s formula, taking prevalence of cervical cancer as 9.4% and absolute error of precision as 5%. Institutional ethical committee clearance and informed consent of study participants were obtained. For evaluation of QoL, a validated questionnaire for women with cervical cancer (Functional Assessment of Cancer Therapy—Cervix Cancer [FACT-Cx]) was used. The total score of FACT-Cx questionnaire ranges from 0 to 168, with higher score indicating better QoL. Data on socio-demographic profile, stage and grade of cancer and treatment modalities were collected and subjected to quantitative analysis using SPSS Version 21.

Results:
The mean age of the patients was 50.28 years, and 69.9% of them were illiterate. 45.6% belonged to middle-class socio-economic status according to BG Prasad’s classification. The overall mean score was 83.42 ± 14.4 standard deviation. Physical well-being was 14.59 ± 4.3, social/family well-being was 14.70 ± 3.68, emotional well-being was 11.79 ± 2.9, functional well-being was 12.20 ± 3.29, and mean score for additional concerns was 30.14 ± 5.37. PWB was affected by educational status (β = 0.212, P = 0.016) and staging of tumour (β = -0.326, P = 0.001).

Conclusion:
This study showed that majority of cervical cancer patients receiving treatment had stable QoL as depicted by social, family and functional well-being. Women with cervical cancer may require counselling, and reasonable efforts should be taken to alleviate their suffering.
Challenges Faced by Undergraduate Students of a Medical College in Kolkata During Family Visits Under Family Adoption Programme: A Mixed-Methods Study
Authors: Chakrabarti Soma , Mishra Ankita , Bysack Ratul Kumar , Chakrabarti Sreetama , Naskar Somnath , Basu Mausumi 
Published: February 2025

ABSTRACT

Background:
Family Adoption Programme (FAP) has been introduced in the curriculum for medical students to help them learn empathy while understanding the customs and limitations of the community. Though this would help in attaining universal health coverage, most of its aspects are still unknown. Through this study, challenges faced by the students could be identified and addressed.

Objectives:
This study aimed to identify and explore the challenges faced by undergraduate students of a medical college in Kolkata during family visit under FAP.

Materials and Methods:
A descriptive study, cross-sectional in design, using a mixed-methods approach (convergent parallel) was conducted for 2 months (from February 6, 2023, to April 8, 2023) at a medical college in Kolkata. On obtaining approval from the Institutional Ethics Committee (IEC) and after obtaining informed written consent from the participants, data were collected from the undergraduate medical students using a predesigned, pretested, and semi-structured questionnaire. In-depth interviews (IDIs) were conducted on purposively selected faculties supervising the visit. The quantitative data were analyzed using Statistical Package for the Social Sciences (SPSS) version 25, while the qualitative data were analyzed thematically.

Results:
The study included 170 students and five faculties. The majority (91.8%) of the students faced challenges during the visit. The most commonly encountered challenge was transport related. Other problems faced were lack of supervision during the examination of the family members, difficulty in communicating, and locating allotted family and safety issues. The faculty members identified challenges related to transportation, burden of community expectations, insufficient clinical exposure, communication, and locating allotted families. On juxtaposition of quantitative and qualitative data, transportation issues, difficulty in locating families, and communication barrier were confirmed.

Conclusion:
Almost all the students faced challenges during the family visits. Challenges, such as transportation issues, finding the family, and language barrier, were confirmed.
Cfr Gene-based Detection of Linezolid-Resistant Staphylococcus Aureus in a Tertiary Care Hospital in Western Uttar Pradesh, India
Authors: Sangita Km. , Pandey Anita , Gupta Geeta , Gupta Ankita 
Published: February 2025

ABSTRACT

Objective:
Linezolid is an important antimicrobial agent which is active against multidrug-resistant Gram-positive cocci. Methicillin-resistant Staphylococcus aureus (MRSA) cause life-threatening infection, with narrow therapeutic options including linezolid and vancomycin. The presence of cfr (chloramphenicol–florfenicol resistance) and optrA (oxazolidinone phenicol resistance) gene plays a crucial role in linezolid resistance.

Materials and Methods:
A total of 199 clinical isolates were confirmed as S. aureus using GP ID p628 card, followed by antibiotic susceptibility testing using GPAST cards in the Vitek 2 compact system (Biomerieux, France) to determine minimum inhibitory concentration (MIC) of linezolid. An MIC value of ≥8 μg/ml was taken as resistant for linezolid. Furthermore, the presence of cfr and optrA gene was looked for in the clinical isolates of linezolid resistant S. aureus (LRSA).

Results:
LRSA was isolated in 2.5% of clinical samples. All LRSA were also MRSA, and all of them were recovered from indoor samples. The LRSA were 100% susceptible to vancomycin. cfr gene could be detected in 40% of the isolates. However, all our isolates of LRSA were negative for optrA gene.

Conclusions:
Emergence of linezolid resistance in clinical isolates of S. aureus is a matter of therapeutic concern which alerts toward judicious use of linezolid in clinical practice. The presence of cfr gene is the most common mechanism of resistance to linezolid.
PKM SOSIALISASI PENGENALAN APLIKASI DASAR KOMPUTER MICROSOFT WORD DAN POWERPOINT DI SMA NEGERI 4 SIBOLGA
Authors: Tanjung Alfansuri , Lubis Rifka Hadia , Matondang Safran , Tanjung Mansur , Koto Mhd. Shafwan , Panggabean Nanda Pratama 
Published: February 2025

ABSTRAK
Tujuan Pelaksanaan PKM ini adalah untuk mengenalkan aplikasi dasar komputer mocrosoft word dan power point di SMA Negeri 4 Sibolga dan membantu mereka mempraktikkannya secara langsung. Metode yang digunakan dalam pengabdian ini adalah metode sosialilasi dan praktik langsung. Pengabdian ini tentunya bertujuan untuk membangun hubungan antara SMA Negeri 4 Sibolga dengan STIE Al Washliyah Sibolga Tapanuli Tengah sebagai mitra pengabdian masyarakat. Program ini diharapkan dapat berjalan dengan baik untuk menmbah wawasan siswa SMA Negeri 4 Sibolga. Hasil dari kegiatan pelatihan ini adalah publikasi karya ilmiah pada prosiding dan jurnal nasional dan jurnal terakreditasi nasional. Hasil dari kegiatan sosialisasi ini menunjukkan bahwa kemampuan siswa SMA Negeri 4 Sibolga sangat memuaskan terlihat dari hasil quiz yang diberikan di akhir sosialisasi.
Kata Kunci : Sosialisasi, Aplikasi Dasar, Microsoft Word Dan Power Point
ANALYSIS OF INFLAMMATORY DISEASES OF THE ORAL CAVITY IN PATIENTS IN NEED OF ORTHOPEDIC CARE
Authors: Khairullayevna Ortikova Nargiza , Khasanovich Irgashev Shohruh , Qizi Turumova Marjona Bahodir 
Published: February 2025

Inflammatory diseases of the oral cavity are a common challenge among patients requiring orthopedic care, significantly affecting their overall health and the success of dental prosthetic treatment. These conditions, which include gingivitis, periodontitis, stomatitis, and periimplantitis, can lead to discomfort, functional impairment, and complications in prosthetic rehabilitation.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL PASTA GIGI EKSTRAK ETANOL ALBEDO SEMANGKA MERAH (Citrulus Lanatus Thumb)
Authors: Suharyanisa  , Marpaung Jon Kenedy , Suhendri Martin , Ayu Herti 
Published: February 2025

Latar belakang: Menurut WHO tahun 2022, karies anak di seluruh dunia mencapai 514 juta. Berdasarkan Global Oral Health Status Report (2022), prevalensi karies anak tertinggi terdapat di wilayah Pasifik Barat sebesar 46,20%, Mediterania Barat sebesar 45,10% dam Asia Tenggara dengan persentase 42,77%(World Health Organization, 2022). Beberapa negara di Asia Tenggara dengan angka karies anak yang tinggi adalah Filipina dan Indonesia (World Health Organization, 2022). Dan data Riskesdas pada tahun 2018, persentase masyarakat Indonesia yang mengalami karies gigi sebesar 45,3%
Tujuan: Untuk menganalisis efek pemutihan gigi dengan menggunakan formulasi gel pasta gigi ekstrak etanol albendo semangka merah (Citrulus Lannatus Thumb) memiliki efek antibakteri .
Metode: Metode penelitian yang dilakukan adalah penelitian eksperimental yang meliputi pengumpulan sampel, identifikasi sampel, pengolahan simplisia, pembuatan ekstrak etanol albedo buah semangka merah,, formulasi sedian gel pasta gigi, dan uji gel pasta gigi terhadap pemutihan gigi.
Hasil:3 Hasil identifikasi sampel albedo semangka yang diidentifikasi di Herbarium Medanese (MEDA), Laboratorium Herbarium FMIPA Universitas Sumatera Utara (USU) menunjukkan bahwa sampel yang digunakan benar kulit eemangka dengan famili Cucurbitales dan spesies Curullus lanatus (Thumb)
Kesimpulan: Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa ekstrak etanol albendo semangka merah (Citrulus Lannatus Thumb) memiliki diameter zona hambat pada ketiga formula. Pada F1, yang mengandung 10 gram ekstrak etanol albedo semangka, diameter zona hambat yang terbentuk berada pada rentang 3,925 mm hingga 6,825 mm termasuk dalam kategori "Sangat Lemah". Untuk F2, yang mengandung 15 gram ekstrak, diameter zona hambat yang dihasilkan sedikit lebih besar dibandingkan F1, yaitu berkisar antara 7,425 mm hingga 7,7425 mm. mm termasuk dalam kategori "Lemah". Formula F3, yang mengandung 20 gram ekstrak etanol albedo semangka, menunjukkan hasil yang paling baik di antara ketiga formula, dengan diameter zona hambat yang berkisar antara 8,75 mm hingga 9,425 mm termasuk dalam kategori "Lemah". Hal ini dapat disimpulkan bahwa ekstrak etanol albendo semangka merah (Citrulus Lannatus Thumb) kurang memberikan aktivitas antibakteri yang bagus yang bagus terhadap Streptococus mutans.
DETERMINANTES SOCIAIS DA SAÚDE: IMPACTOS NO DESENVOLVIMENTO DE CRIANÇAS E ADOLESCENTE EM SITUAÇÕES DE RISCO
Authors: Justino Neila Fernandes , Gomes Rebecca Nascimento da Silveira , Carminatti Micheli , Barros Luís Felipe Morais , Guerra Júlia Maria López , Rodrigues Jefferson Carlos Tolentino , Lopes Juliana de Fatima da Conceição Veríssimo , Anjos Jalmes Silva Pereira dos 
Published: February 2025

Esse artigo buscou analisar os principais determinantes sociais da saúde (DSS) e seus impactos no desenvolvimento de crianças e adolescentes em situação de risco, destacando as implicações para a saúde pública e possíveis estratégias de intervenção. O trabalho avaliou, por meio de uma revisão integrativa da literatura, como fatores como pobreza, violência, insegurança alimentar, precariedade habitacional e acesso limitado a serviços de saúde e educação influenciam negativamente o crescimento físico, cognitivo, emocional e social desses indivíduos. A revisão evidenciou que a exposição a ambientes adversos está associada a maiores riscos de transtornos psicossociais, dificuldades de aprendizagem e desenvolvimento de doenças crônicas, perpetuando desigualdades e ampliando vulnerabilidades. Além disso, a pandemia de COVID-19 exacerbou esses desafios, reforçando a necessidade de políticas públicas intersetoriais que promovam equidade e inclusão social. O estudo concluiu que, embora os DSS representem um desafio significativo, a adoção de medidas estratégicas, como o fortalecimento de redes de apoio comunitário e a ampliação do acesso a serviços essenciais, pode mitigar seus efeitos negativos, garantindo um desenvolvimento mais saudável e equitativo para crianças e adolescentes em situação de risco.
Divisor equitably strong non-split divisor equitable domination in graphs
Authors: G. B. Priyanka , P Xavier , John J. Catherine Grace 
Published: February 2025

In epidemiology, the spread of diseases can be modelled using graphs, where individuals are nodes, and edges represent potential pathways for disease transmission. A non-split dominating set could help identify key individuals (or groups) whose monitoring or immunization would ensure that the rest of the population (the non-dominated group) remains connected and can be controlled in case of disease spread. This approach has the potential to have a significant impact across various areas of medicine. We present the idea of non-split divisor equitable domination in graphs as a way to optimize medical networks. Let Q be a graph with vertex set R(Q) and edge set E (Q). Two vertices h and t are known as degree divisor equitable if gcd(dQ(h), dQ(t)) = 1. F ⊂ R(Q) is known as divisor equitable dominating set of Q if ∀ h ∈ R\F, ∋ a t ∈ F such that h and t are adjacent and degree divisor equitable. The divisor equitable domination number of a graph γde(Q) of Q is the minimum cardinality of a divisor equitable dominating set of Q. In this paper, we introduce the concept of a non-split divisor equitable dominating set, divisor equitably strong non-split divisor equitable dominating set, and divisor equitable independent set and divisor equitable clique number. It also explores the concepts of a divisor equitable vertex dominating set, complement divisor equitable graph, and divisor equitable vertex cut.
Soms moet er iets gebeuren voordat er iets gebeurt
Authors: Houdijk J.C.A. , Snoek M.A.M. 
Published: February 2025

Soms moet er iets gebeuren voordat er iets gebeurt. De implicaties van de arresten in European Superleague, ISU en Royal Antwerp voor de ontwikkeling van het Europees mededingingsrecht
Het Hof van Justitie heeft zich in een drietal spraakmakende sportarresten uitgelaten over een aantal aspecten van de toepassing van het mededingingsrecht op de (commerciële organisatie en exploitatie van de) sportsector, specifieker op de rol van sportbonden en -federaties in de regulering van de professionele sportsector. Het Hof van Justitie buigt zich in deze zaken over de ruimte die sportfederaties (waaronder voetbalbonden) hebben om besluiten te nemen over de mogelijke toetreding van nieuwe partijen tot de sportevenementenmarkt door middel van de introductie van nieuwe competitie- of wedstrijdvormen. Het Hof van Justitie formuleert een aantal voorwaarden waaraan sportfederaties zijn gehouden in de opzet van hun organisatie en reglementen voor de beoordeling van initiatieven tot nieuwe competitievormen of wedstrijden en voor de ter controle ingestelde sancties. Het gaat dan om de beginselen van transparantie, objectiviteit, non-discriminatie en evenredigheid.HvJ 21 december 2023, C-333/21, ECLI:EU:C:2023:1011 (European Superleague Company SL/Fédération internationale de football association (FIFA) et Union des associations européennes de football (UEFA)); HvJ 21 december 2023, C-124/21 P, ECLI:EU:C:2023:1012 (International Skating Union/Europese Commissie); HvJ 21 december 2023, C-680/21, ECLI:EU:C:2023:1010 (UL en SA Royal Antwerp Football Club/Union royale belge des sociétés de football association ASBL).