bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability of fiducial cephalometric landmarks of growing Class II malocclusion patients: a three-dimensional retrospective study
Authors: Santana Lucas Garcia , Cheib Paula Loureiro , de Pársia Henrique Gontijo , Franchi Lorenzo , Moro Alexandre , Souki Bernardo Q. 
Published: June 2022

ABSTRACT

Objectives
To evaluate three-dimensionally (3D) the stability of Nasion (Na), Sella (S), Basion (Ba), Porion (Po), and Orbitale (Or) in different age groups of growing Class II malocclusion patients and, additionally, to assess rotational changes of the S-Na and Ba-Na lines and the Frankfurt Horizontal Plane (FHP).

Materials and Methods
Cone-beam computed tomography studies of 67 Class II division 1 malocclusion patients, acquired at baseline (T0) and 1 year later (T1), were retrospectively assessed. Anterior cranial fossa was used for volumetric superimposition. Subjects were grouped according to their age at T0: group 1 (G1) (8–10 years), G2 (11–13 years), and G3 (14–17 years). Quantitative assessments of the 3D linear displacements (Euclidean distance) in the position of Na, S, Ba, Po, and Or were performed. Displacement in the X, Y, and Z projections and the rotation of S-Na, Na-Ba, and FHP were also quantified.

Results
All cephalometric landmarks showed 3D displacement (P = .001) in the three age groups. Orbitale remained stable in the vertical and sagittal dimension from 8 to 17 years (P &gt; .05). S-Na, Na-Ba, and the FHP showed statistically significant angular rotation (P &lt; .05) in younger patients (G1), while in older individuals (G2 and G3) they were stable (P &gt; .05).

Conclusions
Na, S, Ba, and Po showed vertical and sagittal positional changes relative to the anterior cranial fossa during the growth of Class II individuals. After age 11, S-Na, Na-Ba, and FHP did not show rotation and, thus, are valid parameters for angular cephalometric analysis in Class II growing patients.
Aburrá- Medellín River Water Quality Space-Time Variation from the Electrical Conductivity and Its Use as an Indicator of Quality.
Authors: Giraldo Buitrago Lina Claudia 
Published: June 2022

This article aims to perform a space-time analysis of the electrical conductivity readings measured in the Aburrá - Medellín river, in the period 2006-2020, through the monitoring network of water resources in the region - RedRío, to evaluate the feasibility of using it as an indicator of water quality in the three automatic monitoring stations that are part of this network.
The classification of the flow regime was carried out considering the historical record of flows measured between 2004 and 2020 in the region's water resources monitoring network - RedRío. Then, to evaluate if there were statistically significant differences between the electrical conductivity measured in the stations and for the measurements in the three flow ranges, the non-parametric Kruskal Wallis test was performed, since the assumptions required for an analysis of variance were not met. Finally, to make the state of the river more visible from the electrical conductivity measurements, a categorization by ranges (quartiles) and color assignment is proposed, as established in the ICA water quality indices.
As a result of this study, two classifications of electrical conductivity expressed in five color ranges are proposed, as well as the quality index for surface water – ICA-. Finally, the readings obtained in the automatic stations from August 2019 to March 2020 are reviewed and classification ranges for these stations are adjusted.
This research highlights the proposal to introduce the use of this variable as an indicator of water quality, to illustrate and continuously inform the community about the state of the Aburrá- Medellín river through a color code, to sensitize the inhabitants of the basin on its protection, care, and the importance of efficiently use and save water.
Prospects of PARP Inhibitors in Treatment of BRCA-Mutated Pancreatic Cancer: a Literature Review
Authors: Menshikov K. V. , Sultanbaev A. V. , Musin Sh. I. , Izmailov A. A. , Menshikova I. A. , Sultanbaeva N. I. , Popova E. V. , Khammatova L. A. 
Published: June 2022

Pancreatic adenocarcinoma has a 5-year overall survival rate of 9 %, with an outlook of becoming the second leading cause of cancer mortality in the USA by 2030. Familial pancreatic cancer and genetic predisposition syndromes have attracted more interest in the perspective of targeted therapy. Various authors estimate genetic causes to account for 10–15 % of pancreatic cancers. The BRCA gene mutations comprise the today’s most relevant genetic predisposition syndrome. The frequency of BRCA1/2 and PALB2 germinal mutations in patients with pancreatic adenocarcinoma constitutes about 5–9 %. Over recent years, PARP inhibitors (PARPi) have composed a new targeted therapy class with a significant effect in breast and ovarian cancers. With the mechanism of action of the PARP inhibitor and platinum drugs targeting different DNA repair pathways, their combination therapy has been suggested as promising. We report studies of a combination treatment with veliparib, gemcitabine and cisplatin in germinal BRCA1/2-mutation patients with advanced wild-type pancreatic adenocarcinoma (WT). Recent advances have identified patients with germinal and somatic mutations in the BRCA1/2 and other genes. HRD-targeted therapy, including platinum and PARP inhibitor drugs, can significantly improve survival.
Serotonin receptor subtype-2B signaling is associated with interleukin-18-induced cardiomyoblast hypertrophy in vitro
Authors: Chen Chao-Yi , Leu Jyh-Gang , Lin Kuan-Yu , Shih Chin-Yu , Liang Yao-Jen 
Published: June 2022

Abstract

Background
In patients with heart failure, interleukin-18 (IL-18) levels increase in the circulatory system and injured myocardial tissue. Serotonin (5-hydroxytryptamine) receptors subtype 2B (HTR2B) play an essential role in cardiac function and development, and their overexpression in rats leads to myocardial hypertrophy. Epigallocatechin gallate (EGCG) is cardioprotective in myocardial ischemia–reperfusion injury in rats and can prevent pressure overload-mediated cardiac hypertrophy in vivo. Mice deficient in peroxisome proliferator-activated receptor delta (PPARδ) can have cardiac dysfunction, myocardial hypertrophy, and heart failure. Matrix metalloproteinases (MMPs) are possibly involved in cardiac remodeling. However, the relationship between IL-18 signaling, cardiac hypertrophy, and the molecular mechanisms involved remain to be fully elucidated.

Objectives
To elucidate the relationship between HTR2B and IL-18-induced myocardial hypertrophy and examine the antihypertrophic effects of EGCG and PPARδ.

Methods
We induced H9c2 cardiomyoblast hypertrophy with IL-18 in vitro and investigated the downstream signaling by real-time polymerase chain reaction (PCR) and western blotting. Hypertrophy was assessed by flow cytometry. We determined the effects of EGCG and PPARδ on IL-18-induced hypertrophic signaling via HTR2B-dependent mechanisms.

Results
IL-18-induced H9c2 hypertrophy upregulated brain natriuretic peptide (BNP) protein and mRNA expression by inducing the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and the hypertrophy was attenuated by pretreatment with EGCG (20 μM) and L-165,041 (2 μM), a PPARδ agonist. IL-18 upregulated the expression of HTR2B, which was inhibited by pretreatment with EGCG and L-165,041. SB215505 (0.1 μM), a HTR2B antagonist and siRNA for HTR2B, attenuated H9c2 hypertrophy significantly. Inhibition of HTR2B also downregulated the expression of MMP-3 and MMP-9.

Conclusions
IL-18 and HTR2B play critical roles in cardiomyoblast hypertrophy. EGCG and L-165,041 inhibit the expression of HTR2B and augment remodeling of H9c2 cardiomyoblasts, possibly mediated by MMP-3 and MMP-9.
KUALITAS DAN TINGKAT PENCEMARAN AIR WADUK TITAB, BULELENG
Authors: Dewi Ayu Meiliana Laksmi , Juliasih Ni Ketut Ayu , Arsana I Nyoman 
Published: June 2022

Monitoring water sources is essential to ensure the quality and quantity, one of which is in the Titab Reservoir. The purpose of the study was to assess the water quality and amount of pollution in the Titab reservoir in terms of physical, chemical, and microbiological characteristics, as well as the NVC of Tawes (Barbonymus gonionotus) fish. There are five station points for water sampling and 10 test parameters related to water quality. Data analysis compares test results with second-class water quality standards (Bali Governor Regulation No. 16/2016), IP value (pollution index), and NVC with Furton's equation. The test results obtained that the water in the Titab reservoir has a temperature of 28.97oC, TSS (0.18 mg/L), pH (8.82), BOD (3.22 mg/L), COD (16.70 mg/L), DO (6.77 mg/L), Total Phosphate (0.12 mg/L), Nitrate (0.19 mg/L) and Fecal Coliform (960 MPN/100 mL), the IP value was 1.39, and the NVC was 1.65. Thus, the pH, BOD, and Fecal Coliform levels of the Titab reservoir water did not match the specified limits, although the other parameters satisfied the water quality norms. The Titab reservoir's water is classed as mildly contaminated with the NVC value of tawes fish, referring to the Titab reservoir's polluted water.
Keywords: Tawes Fish, Titab Reservoir, Water pollution, Water quality.
EFEKTIVITAS PEMANFAATAN KULTUR LOKAL DALAM BIOREAKTOR PENGOLAHAN AIR LIMBAH KERAJINAN ENDEK
Authors: Juliasari Ni Made Tia , Budiarsa Suyasa I Wayan , Rai I Nyoman 
Published: June 2022

Endek is one of the fabrics that are in demand by local and foreign people. The distinctive pattern of this endek cloth continues to develop while still paying attention to the authenticity of the endek motives from Bali so that it is easily recognized by the public, however, in its production, it produces waste that causes environmental pollution therefore it needs to be managed. One of the easy and efficient textile waste management is a bioreactor by utilizing local culture. Local cultures are indicated as indigenous microorganisms originating from the waste itself. The purpose of this study is to analyze the effectiveness of local cultures in bioreactors in improving wastewater quality and analyze the effectiveness of using local microbial cultures in bioreactors for treating endek wastewater. This study applied a quantitative approach with experimental methods. The processing begins with the growth of biofilms to determine the biomass profile using the Mixed Liquor Suspended Solid (MLSS) method, then the color waste water is stored in an anaerobic reservoir for 24 hours then tested and then processing, later it is inundated for 1 hour before parameter measurement. The parameters tested were COD levels, color content and pH. Based on the results of the study, the optimum MLSS value obtained in the seeding process was 4490 mg/L on the 7th day and the biofilm growth biomass profile of 3240 mg/L on the 22nd day. The utilization of local microbial culture in the bioreactor in this study was effective in reducing the color content parameter by 77% at processing times of 384 and 408 hours, and decreasing pH was only effective at processing time of 6 hours and reducing COD was not effective.
Keywords : endek wastewater, local culture, bioreactor, effectivenes
ANALISIS KUALITAS AIR SUMUR GALI BERDASARKAN INDEKS PENCEMARAN SERTA PERSEPSI DAN PERILAKU MASYARAKAT DI DESA SANUR KAUH DENPASAR SELATAN
Authors: Kahar Gertrudis Vebriyanti , Sudiana Mahendra Made , Mahardika I Gede 
Published: June 2022

The goal of the study was to analyze the water quality of dug wells based on Bali Governor Regulation No. 16 of 2016 and Regulation of the Minister of Health of the Republic of Indonesia No.492/Menkes/Per/IV/2010, which analyzes the quality status of dug well water and its distribution based on the Pollution Index (IP) value and community behavior in Sanur Kauh Village, South Denpasar. Purposive sampling at three stations with three repeats was used to determine the sample. Temperature, color, taste, odor, TDS, turbidity, pH, DO, BOD, COD, Nitrate (NO3-N), Phosphate (PO4), Chloride (Cl-), Iron (fe), E. Coli, and total coliforms were among the parameters measured in situ and ex situ (laboratory). Questionnaires and interviews with respondents who used dug well water were used to collect data on perception and behavior of components (households, business actors and/or activities, farmers, and the government), which were analyzed using a Likert scale and binary model. Surfer and GIS were used to map the water from an excavated well. The results of the analysis of the quality of dug well water exceeded the Class I Water quality standard set by Bali Governor Regulation No. 16 of 2016 for BOD, COD, phosphate, nitrate, iron, total coliform, and turbidity parameters, as well as the Indonesian Minister of Health Regulation No.492/Menkes /Per/IV/2010 for BOD, COD, phosphate, nitrate, iron, total coliform, and turbidity parameters Population activities, pollution sources, climate, soil type and topography, height and depth of the well all influence the water quality status of dug wells, which is classified as moderately polluted. The average community's impression of the provision of dug well water, water pollution, and waste management is positive, and the average community conduct is positive.
Keywords: Shallow Groundwater, Groundwater Quality, Quality Status, Perception, Behavior
EFEKTIVITAS MIKROALGA Chlorella vulgaris DAN Spirulina plantensis DALAM BIOSORPSI LOGAM NIKEL DI PERAIRAN (KASUS PERAIRAN POMALAA KABUPATEN KOLAKA)
Authors: Zakir Ahmad , Budiarsa Suyasa I Wayan , Astarini Ida Ayu 
Published: June 2022

Mining and nickel processing activities in Pomalaa, Kolaka Regency have an impact on the condition of coastal waters. Several researchers who have conducted research in the area stated that the Pomalaa coast has been polluted by the presence of nickel metal so that there is an initiative to reduce the impact of Ni in the waters by bioremediation of the microalgae Chlorella vulgaris and Spirulina platensis. This study aims to analyze the growth of microalgae types C. vulgaris and S. platensis cultured on media containing nickel with different concentrations and also to determine the ability of microalgae to reduce nickel heavy metals at different concentrations. This research was carried out at the Fisheries Laboratory of Haluoleo University , while the AAS (Atomic Absorption Spectrophotometric) analysis was carried out at the Kendari Environmental Laboratory UPTD Laboratory on January – May 2021. The results of the analysis showed that there was a significant difference in the growth density of microalgae cells (C. vulgaris and S. platensis) which were given the treatment/concentration. Ni different. The absorption capacity of C. vulgaris ranged from 0.73 to 4.97 mg/l, while s. platensis ranged from 0.082 – 2.11 mg/l. C. vulgaris is superior in reducing nickel because C. vulgaris can live in polluted water conditions.
Keywords: Bioremediation; Nickel; C. vulgaris; S. platensis.
ANALISIS DAYA DUKUNG MONKEY FOREST UBUD SEBAGAI DAYA TARIK WISATA BERKELANJUTAN
Authors: Putri Niken Prameswari , Rai I Nyoman , Agung Suryawan A.A.P 
Published: June 2022

Monkey Forest Ubud is located in the Padang Tegal Village, Ubud District. The area of ????the tourism forest is about 12.5 ha. Tourism activities at Monkey Forest Ubud tend to be mass tourism activities. This study aims to measure the position of the effective carrying capacity of Monkey Forest Ubud based on biotic and abiotic variables, perceptions of tourism actors (tourists and management) towards tourism activities, condition of facilities and infrastructure and management of Monkey Forest Ubud, as well as alternative strategies for the realization of environmental sustainability and tourism. The method used to analyze the carrying capacity of the environment according to Cifuentes, drafting alternative sustainable management strategies for Monkey Forest Ubud with QSPM analysis. The results of the carrying capacity analysis show the ECC of 257 people/day. The average tourist visit in 2010-2019 reached 1,784 people/day, exceeding the ECC value indicates a threat to the biotic and abiotic factors that affect it. Alternative strategies resulting from the QSPM analysis for the realization of sustainable tourism with a score of 4.88 are alternative tourism in the form of educational tours in the Yadnya forest and event procurement in non-forest areas, the second strategy with a score of 4.86 is to maximize the digital marketing function, namely buying tickets online with providing daily visit quotas for tourist restrictions, the third strategy with a score of 4.66 is to increase ticket prices by 50% from normal tickets.The existence of the Ubud Monkey Forest has a positive impact on the social and economic aspects of the Padang Tegal Village community, but environmental sustainability needs to be considered, one of which is the restriction of tourist visits.
Keywords: carrying capacity, sustainable tourism, Quantitative Strategy Planning Matrix
Potential of Genitri (Elaeocarpus sphaericus Schum.) on Leukocytes and Pulmonary Tissue Structure Influenza Virus Induced Wistar Rat
Authors: Primiani Cicilia Novi , Pujiati Pujiati , Setiawan Mohammad Arfi 
Published: June 2022

Genitri (Elaeocarpus sphaericus Schum.) is an endemic plant of Indonesia that has not been widely cultivated and utilized. The use of genitri is usually as road shade, firewood, seeds for jewelry. The results showed that the diversity of chemical compounds genitri had potential for health. The aim of the study was to analyze the potential of genitri to leukocytes and lung tissue structure of wistar rats induced by influenza virus. The study used an experimental approach, with experimental animals in the form of 24 male wistar rats in 4 treatment groups, P0 negative control, P1 influenza virus induction (positive control), P2 influenza virus induction and given genitri leaf, and P3 influenza virus induction and given genitry seeds. Virus induction on day 0 and day 14. Leaves and seeds were given on the 3rd day. Surgery was performed on day 5 and day 33. The number of leukocytes were calculated using microhematocrit, and identified leukocytes and lung tissue structure staining with HE staining. The results showed that genitry seeds could increase the number of leukocytes up to 13,000 cells/µL, the size of the alveoli diameter was 31.48 m, the size of the alveolar septum was 12.02 m.
Keywords: Antiviral, Elaeocarpus Sphaericus Schum, Genitri, Leukocytes, Pulmo
Wound Healing Of Cuts in the Skin of White Rat (Rattus norvegicus) Is Given Kirinyuh (Chromolaena odorata) Leaf Extract
Authors: Amfotis Maria Lorita , Suarni Ni  Made Rai , Arpiwi Ni Luh 
Published: June 2022

Daun kirinyuh (Chromoelana odorata) merupakan tanaman yang secara tradisional digunakan masyarakat untuk menyembuhkan luka. Daun kirinyuh mengandung senyawa alkaloid, flavonoid, fenol, saponin, triterpenoid dan tanin. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun kirinyuh terhadap penyembuhan luka sayat pada kulit tikus putih. Penelitian ini menggunakan Rancangan Acak Lengkap, terdiri dari lima perlakuan dan masing-masing perlakuan terdapat enam ulangan. Digunakan 30 ekor tikus putih dengan kisaran berat badan 200-250 g. Tikus dibagi dalam lima perlakuan yaitu K- (diberi aquades), K+ (diberi povidone iodine 10%), perlakuan (P1, P2, P3) yang diberikan ekstrak daun kirinyuh 10%, 20%, 30%. Pengamatan secara makroskopis dilakukan pada hari ke-3, 6 dan 9 terhadap hiperemis, kontraksi luka, granulasi, krusta dan produksi pus. Pembuatan sediaan untuk pengamatan secara secara mikroskopis (ketebalan epidermis, jumlah fibroblas dan jumlah kolagen) dilakukan pada hari ke 10. Data makroskopis selain kontraksi luka dianalisa secara deskriptif. Data kontraksi luka, ketebalan epidermis, jumlah fibroblas dan jumlah kolagen dianalisis menggunakan ANOVA (p<0,05) dan bila terdapat perbedaan yang nyata maka dilanjutkan dengan uji Duncan. Hasil pengamatan terhadap penyembuhan luka secara makroskopis menunjukkan bahwa konsentrasi 20% paling optimal dalam menurunkan hiperemis dan kontraksi luka. Sedangkan konsentrasi 10% paling optimal dalam pembentukan granulasi, mencegah krusta dan produksi pus. Hasil pengamatan terhadap penyembuhan luka secara mikroskopis menunjukkan bahwa konsentrasi 20% (P2) paling optimal dalam meningkatkan ketebalan epidermis, meningkatkan jumlah fibroblas dan jumlah kolagen. Dapat disimpulkan bahwa ekstrak daun kirinyuh dapat menyembuhkan luka secara optimal dengan konsentrasi yang berbeda-beda pada setiap tahap penyembuhan.
Kata kunci: Chromoelana odorata, metabolit sekunder, penyembuhan luka, Rattus norvegicus.
Analisis Kandungan Klorofil-A dan Kualitas Air Waduk Ciwaka Kota Serang Banten
Authors: Lail Sakhirotul , KN Aditya Rahman , Khastini Rida Oktorida 
Published: June 2022

Penelitian dilakukan untuk mengetahui kualitas perairan Waduk Ciwaka, Kota Serang Banten berdasarkan kandungan klorofil-a dan keberadaan fitoplankton, mengetahui hubungan kandungan klorofil-a dan keberadaan fitoplankton dengan parameter fisik-kimia perairan serta mengetahui bentuk media pembelajaran yang sesuai untuk menginterpretasikan hasil penelitian terhadap kependidikan. Penelitian ini dilaksanakan dari bulan Februari-Juli tahun 2021 di Waduk Ciwaka, Kota Serang Banten. Pengambilan sampel air pada 3 stasiun dilakukan menggunakan metode purposive sampling. Analisis klorofil-a dilakukan menggunakan metode spektrofotometri. Hasil analisis kandungan klorofil-a pada setiap stasiun berkisar 7,458 ?g/L – 34,352 ?g/L. Waduk Ciwaka termasuk dalam kategori perairan yang mengalami eutrofik (tercemar) karena memiliki kadar unsur hara yang tinggi. Kualitas perairan Waduk Ciwaka masih dalam kondisi yang baik sesuai peruntukan baku mutu air kelas 2 pada PP No.82 tahun 2001. Kandungan klorofil-a dan keberadaan fitoplankton (kelimpahan, keanekaragaman dan dominansi) berhubungan lemah dengan kecerahan (r = 0,000). Keanekaragaman fitoplankton berhubungan sangat kuat dengan suhu (r = 0,994). Dominansi fitoplankton berhubungan sangat kuat dengan DO (r = 0,998) dan BOD (r = 0,998).

Kata kunci: Eutrofik, Klorofil-a, Waduk Ciwaka
Laparoscopic cholecystectomy in patients with COVID–19 and in a postcovid period
Authors: Mіshchenko V. V. , Pustovoit P. І. , Vododiuk R. Yu. , Velichko V. V. 
Published: June 2022

Objective. Determination of the role and place for laparoscopic cholecystectomy on background of COVID-19 and in postcovid period.
Materials and methods. Laparoscopic cholecystectomy was performed in 54 patients, suffering cholelithiasis, complicated by an acute calculous cholecystitis, who suffered or have had COVID-19 previously.
Results. Duration of the disease befor hospitalization into the stationary more than 24 h was noted in 45(83,3%) patients. Destructive form of the gallbladder inflammation have appeared a typical one. Antibodies IgM and IgG for SARS-Cov-2 (COVID-19) and positive PCR-test, diagnostic for the viral RNA residuals was noted in 100% of the patients.
Conclusion. The cholelithiasis and an acute clculous cholecystitis course in the patients, suffering COVID-19 or those who have had this disease, is accompanied by certain clinical peculiarities. Diagnosis of cholelithiasis and an acute calculous cholecystitis in the patients having COVID-19 or in a postcovid period must be rapid and precise. Laparoscopic cholecystectomy must be considered a «gold standard» as the operation for cholelithiasis and an acute calculous cholecystitis in the patients, suffering COVID-19 or in a postcovid period.