bluuebunny/crossref_metadata_2025_split huggingface dataset:
What matters in mental health care? A co-design approach to developing clinical supervision tools for practitioner competency development
Authors: Böhm Bettina , Keane Gregory , Karimet Myriam , Palma Miguel 
Published: October 2022

AbstractBackgroundSpecialised mental health (MH) care providers are often absent or scarcely available in low resource and humanitarian settings (LRHS), making MH training and supervision for general health care workers (using task-sharing approaches) essential to scaling up services and reducing the treatment gap for severe and common MH conditions. Yet, the diversity of settings, population types, and professional skills in crisis contexts complicate these efforts. A standardised, field tested instrument for clinical supervision would be a significant step towards attaining quality standards in MH care worldwide.MethodsA competency-based clinical supervision tool was designed by Médecins Sans Frontières (MSF) for use in LRHS. A systematic literature review informed its design and assured its focus on key clinical competencies. An initial pool of behavioural indicators was identified through a rational theoretical scale construction approach, tested through waves of simulation and reviewed by 12 MH supervisors in seven projects where MSF provides care for severe and common MH conditions.ResultsQualitative analysis yielded two sets of competency grids based on a supervisee's professional background: one for ‘psychological/counselling’ and another for ‘psychiatric/mhGAP’ practitioners. Each grid features 22–26 competencies, plus optional items for specific interventions. While the structure and content were assessed as logical by supervisors, there were concerns regarding the adequacy of the tool to field reality.ConclusionsHumanitarian settings have specific needs that require careful consideration when developing capacity-building strategies. Clinical supervision of key competencies through a standardised instrument represents an important step towards ensuring progress of clinical skills among MH practitioners.
The Politics of Private Violence: How Intimate Partner Violence Victimization Influences Political Attitudes
Authors: Kras Helen Rabello 
Published: October 2022

ABSTRACTThis study examines the relationship between personal experience with intimate partner violence (IPV) and political attitudes. I argue that by adopting salient legislation on violence against women, the state enables survivors to evaluate government performance on the basis of their ability to access resources for victims. As such, when survivors are unable to reach specialized public services, they might downgrade their evaluations of government performance. Focusing on Brazil and using survey data and qualitative interviews, this study finds that IPV survivors who have not used specialized services hold more negative views of government performance compared to nonvictims. Further analysis, including a series of placebo tests, lends additional support to the main results. This study has an intersectional component, as it also examines the relationship between race and access to services. These findings have implications for victims’ democratic rights and access to justice.
From Mesoamerican History to the History of Mexican Archaeology
Authors: Holley-Kline Sam 
Published: October 2022

This essay reviews the following works:The Alchemy of Conquest: Science, Religion, and the Secrets of the New World. By Ralph Bauer. Charlottesville: University of Virginia Press, 2019. Pp. 670. $79.50 hardcover. ISBN: 9780813942544.On the Lips of Others: Moteuczoma’s Fame in Aztec Monuments and Rituals. By Patrick Thomas Hajovsky. Austin: University of Texas Press, 2015. Pp. vii + 194. $45.00 paperback. ISBN: 9781477307243.Time and the Ancestors: Aztec and Mixtec Ritual Art. By Maarten Jansen and Gabina Aurora Pérez Jiménez. Leiden: Brill, 2017. Pp. ix + 615. $182.54 hardcover. ISBN: 9789004340510.En busca del alma nacional: La arqueología y la construcción del origen de la historia nacional en México (1867–1942). By Haydeé López Hernández. Ciudad de México: Instituto Nacional de Antropología e Historia, 2018. Pp. 389. $44.99. paperback. ISBN: 9786075391120.The Value of Things: Prehistoric to Contemporary Commodities in the Maya Region. Edited by Jennifer P. Mathews and Thomas H. Guderjan. Tucson: University of Arizona Press, 2017. Pp. iii + 309. $65.00 hardcover. ISBN: 9780816533527.In the Lands of Fire and Sun: Resistance and Accommodation in the Huichol Sierra, 1723–1930. By Michele McArdle Stephens. Lincoln: University of Nebraska Press, 2018. Pp. ix + 177. $50.00 hardcover. ISBN: 9780803288584.Género, ciencia y política: Voces, vidas y miradas de la arqueología mexicana. By Apen Ruiz Martínez. Ciudad de México: Instituto Nacional de Antropología e Historia, 2016. Pp. 251. Paperback. ISBN: 9786074847970.The Fifteenth Month: Aztec History in the Rituals of Panquetzaliztli. By John F. Schwaller. Norman: University of Oklahoma Press, 2019. Pp. ix + 264. $39.95 hardcover. ISBN: 9780806162768.
Joint association of alcohol consumption and adiposity with alcohol- and obesity-related cancer in a population sample of 399,575 UK adults
Authors: Inan-Eroglu Elif , Huang Bo-Huei , Sarich Peter , Nassar Natasha , Stamatakis Emmanuel 
Published: October 2022

AbstractObesity and alcohol consumption are both important modifiable risk factors for cancer. We examined the joint association of adiposity and alcohol consumption with alcohol- and obesity-related cancer incidence. This prospective cohort study included cancer-free UK Biobank participants aged 40–69 years. Alcohol consumption was categorised based on current UK guidelines into four groups. We defined three markers of adiposity: body fat percentage (BF %), waist circumference and BMI and categorised each into three groups. We derived a joint alcohol consumption and adiposity marker variable with twelve mutually exclusive categories. Among 399 575 participants, 17 617 developed alcohol-related cancer and 20 214 developed obesity-related cancer over an average follow-up of 11·8 (SD 0·9) years. We found relatively weak evidence of independent associations of alcohol consumption with cancer outcomes. However, the joint association analyses showed that across all adiposity markers, above guideline drinkers who were in the top two adiposity groups had elevated cancer incidence risk (e.g. HR for alcohol-related cancer was 1·53 (95 % CI (1·24, 1·90)) for within guideline drinkers and 1·61 (95 % CI (1·30, 2·00)) for above guideline drinkers among participants who were in the top tertile BF %. Regardless of alcohol consumption status, the risk of obesity-related cancer increased with higher adiposity in a dose–response manner within alcohol consumption categories. Our study provides guidance for public health priorities aimed at lowering population cancer risk via two key modifiable risk factors.
Ownership or possession? On Bart Wilson's concept of ownership
Authors: Decker Frank 
Published: October 2022

AbstractIn a recent article Wilson explores the origins and explanation of ownership (property) as a custom, and argues that the custom of ownership is the primary concept and that property rights are subordinated to ownership. I argue that Wilson's subordination argument is unpersuasive; the linguistic evidence used by Wilson fits better with the concept of possession; and ownership is not a human universal.
Overlapping consensus view of human rights: a Rawlsian conception
Authors: Herr Ranjoo Seodu 
Published: October 2022

AbstractThis paper advances and defends the overlapping consensus view of human rights (OCV) as a political conception of human rights most consistent with John Rawls's normative account of a realistic utopia at the international level. Although some clues exist inThe Law of Peoplesto support this view, an innovative reconstruction is called for to complete the picture. This paper aims to offer such a reconstruction, which is predicated on two premises: first, the parties to the international original positions, which include decent nonliberal peoples (DNPs), are reasonable and worthy of liberal toleration; and, second, the protection of human rights proper is a module that can fit into all acceptable comprehensive doctrines at the international level, including societal comprehensive doctrines in DNPs. The first premise has been subjected to vehement liberal critiques and left for dead, and the second premise has not been taken seriously and relatively neglected. This paper defends these premises in turn to justify the OCV as constitutive of Rawls's normative account of a realistic utopia at the international level.
Living With Cosmic Radiation
Authors: Strauss R. Du Toit 
Published: October 2022

AbstractThe last two decades of cosmic ray research have been eventful, to say the least. The Voyager spacecraft explored the outer‐most regions of the heliosphere and eventually left our local astrosphere to explore the galaxy. At the same time, the Parker Solar Probe spacecraft, amongst many other exciting recent missions, is exploring the inner‐most regions of the heliosphere and probing the source of the solar wind. I have been lucky enough to experience these paradigm‐shifting observations as a post‐graduate student and thereafter as a young researcher. In this paper, I give a firsthand account of the last two decades' cosmic ray research from the perspective of a young researcher from South Africa.
Simulating Aerosol Lifecycle Impacts on the Subtropical Stratocumulus‐to‐Cumulus Transition Using Large‐Eddy Simulations
Authors: Erfani Ehsan , Blossey Peter , Wood Robert , Mohrmann Johannes , Doherty Sarah J. , Wyant Matthew , O Kuan‐Ting 
Published: October 2022

AbstractObserved stratocumulus to cumulus transitions (SCTs) and their sensitivity to aerosols are studied using a large‐eddy simulation (LES) model that simulates the aerosol lifecycle, including aerosol sources and sinks. To initialize, force, and evaluate the LES, we used a combination of reanalysis, satellite, and aircraft data from the 2015 Cloud System Evolution in the Trades field campaign over the Northeast Pacific. The simulations follow two Lagrangian trajectories from initially overcast stratocumulus (Sc) to the tropical shallow cumulus region near Hawaii. The first trajectory is characterized by an initially clean, well‐mixed Sc‐topped marine boundary layer (MBL), then continuous MBL deepening and precipitation onset followed by a clear SCT and a consistent reduction of aerosols that ultimately leads to an ultra‐clean layer in the upper MBL. The second trajectory is characterized by an initially polluted and decoupled MBL, weak precipitation, and a late SCT. Overall, the LES simulates the observed general MBL features. Sensitivity studies with different aerosol initial and boundary conditions reveal aerosol‐induced changes in the transition, and albedo changes are decomposed into the Twomey effect and adjustments of cloud liquid water path and cloud fraction. Impacts on precipitation play a key role in the sensitivity to aerosols: for the first case, runs with enhanced aerosols exhibit distinct changes in microphysics and macrophysics such as enhanced cloud droplet number concentration, reduced precipitation, and delayed SCT. Cloud adjustments are dominant in this case. For the second case, enhancing aerosols does not affect cloud macrophysical properties significantly, and the Twomey effect dominates.
An Effective and Efficient Method for Identification of Contamination Sources in Water Distribution Systems Based on Manual Grab‐Sampling
Authors: Ji Yiran , Zheng Feifei , Du Jiawen , Huang Yuan , Bi Weiwei , Duan Huan‐Feng , Savic Dragan , Kapelan Zoran 
Published: October 2022

AbstractMost of the contamination source localization methods for water distribution systems (WDSs) assume the availability of accurate water quality models and multi‐parameter online sensors, which are often out of reach of many water utilities. To address this, a novel manual grab‐sampling method (MGSM) is developed to effectively and efficiently locate continuous contamination sources in a WDS using a dynamic and cyclical sampling strategy. The grab samples are collected at a pre‐specified number of hydrants by the corresponding teams followed by laboratory tests. The MGSM optimizes the sampling plan at each cycle by making the probability of contamination source(s) in each sub‐network as equal as possible, where sub‐networks are determined by the selected hydrants and current flow pipe directions. The CS's size is reduced at each cycle by exploiting sample testing results obtained in the previous cycle until there are no further hydrants to sample from. Two real‐world WDSs are used to demonstrate the effectiveness of the proposed MGSM. The results obtained show that the MGSM can significantly reduce the spatial range of the CS (to about 5% of the entire WDS) for a range of scenarios including multiple contamination sources and pipe flow direction changes. We found that an optimal number of sampling teams exists for a given WDS, representing a balanced trade‐off between detection efficiency and sampling/testing budgets. Due to its relative simplicity, the proposed MGSM can be used in engineering practice straightaway and it represents a viable alternative to the methods associated with water quality models and sensors.
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling
Authors: Ai Jingwen , Guo Jingxin , Zhang Haocheng , Zhang Yi , Yang Haochen , Lin Ke , Song Jieyu , Fu Zhangfan , Fan Mingxiang , Zhang Qiran , Wang Hongyu , Zhao Yuanhan , He Zhangyufan , Cui An , Zhou Yang , Wu Jing , Zhou Mingzhe , Yuan Guanmin , Kang Boxi , Zhao Ning , Xu Yuanyuan , Zhu Mengqi , Wang Youhong , Zhang Zemin , Jiang Ning , Qiu Chao , Xu Chenqi , Zhang Wenhong 
Published: October 2022

AbstractSARS-CoV-2 vaccine booster dose can induce a robust humoral immune response, however, its cellular mechanisms remain elusive. Here, we investigated the durability of antibody responses and single-cell immune profiles following booster dose immunization, longitudinally over 6 months, in recipients of a homologous BBIBP-CorV/BBIBP-CorV or a heterologous BBIBP-CorV/ZF2001 regimen. The production of neutralizing antibodies was dramatically enhanced by both booster regimens, and the antibodies could last at least six months. The heterologous booster induced a faster and more robust plasmablast response, characterized by activation of plasma cells than the homologous booster. The response was attributed to recall of memory B cells and the de novo activation of B cells. Expanded B cell clones upon booster dose vaccination could persist for months, and their B cell receptors displayed accumulated mutations. The production of antibody was positively correlated with antigen presentation by conventional dendritic cells (cDCs), which provides support for B cell maturation through activation and development of follicular helper T (Tfh) cells. The proper activation of cDC/Tfh/B cells was likely fueled by active energy metabolism, and glutaminolysis might also play a general role in promoting humoral immunity. Our study unveils the cellular mechanisms of booster-induced memory/adaptive humoral immunity and suggests potential strategies to optimize vaccine efficacy and durability in future iterations.
Sleep decreases neuronal activity control of microglial dynamics in mice
Authors: Hristovska I. , Robert M. , Combet K. , Honnorat J. , Comte J-C , Pascual O. 
Published: October 2022

AbstractMicroglia, the brain-resident immune cells, are highly ramified with dynamic processes transiently contacting synapses. These contacts have been reported to be activity-dependent, but this has not been thoroughly studied yet, especially in physiological conditions. Here we investigate neuron-microglia contacts and microglia morphodynamics in mice in an activity-dependent context such as the vigilance states. We report that microglial morphodynamics and microglia-spine contacts are regulated by spontaneous and evoked neuronal activity. We also found that sleep modulates microglial morphodynamics through Cx3cr1 signaling. At the synaptic level, microglial processes are attracted towards active spines during wake, and this relationship is hindered during sleep. Finally, microglial contact increases spine activity, mainly during NREM sleep. Altogether, these results indicate that microglial function at synapses is dependent on neuronal activity and the vigilance states, providing evidence that microglia could be important for synaptic homeostasis and plasticity.
Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses
Authors: Jia Janice Zhirong , Tan Chee Wah , Cheng Samuel M. S. , Gu Haogao , Yeoh Aileen Ying Yan , Mok Chris Ka Pun , Wang Yanqun , Zhao Jincun , Leung Nancy H. L. , Cowling Benjamin J. , Poon Leo L. M. , Hui David S. C. , Wang Linfa , Peiris Malik , Valkenburg Sophie A. 
Published: October 2022

AbstractVaccines that are broadly cross-protective against current and future SARS-CoV-2 variants of concern (VoC) or across the sarbecoviruses subgenus remain a priority for public health. Virus neutralization is the best available correlate of protection. To define the magnitude and breadth of cross-neutralization in individuals with different exposure to SARS-CoV-2 infection and vaccination, we here use a multiplex surrogate neutralization assay based on virus spike receptor binding domains of multiple SARS-CoV-2 VoC, as well as related bat and pangolin viruses. We include sera from cohorts of individuals vaccinated with two or three doses of mRNA (BNT162b2) or inactivated SARS-CoV-2 (Coronavac or Sinopharm) vaccines with or without a history of previous SARS-CoV-2 or SARS-CoV-1 infection. SARS-CoV-2 or SARS-CoV-1 infection followed by BNT162b2 vaccine, Omicron BA.2 breakthrough infection following BNT162b2 vaccine or a third dose of BNT162b2 following two doses of BNT162b2 or Coronavac elicit the highest and broadest neutralization across VoCs. For both breadth and magnitude of neutralization across all sarbecoviruses, those infected with SARS-CoV-1 immunized with BNT162b2 outperform all other combinations of infection and/or vaccination. These data may inform vaccine design strategies for generating broadly neutralizing antibodies to SARS-CoV-2 variants or across the sarbecovirus subgenus.
Population genomics of Puccinia graminis f.sp. tritici highlights the role of admixture in the origin of virulent wheat rust races
Authors: Guo Yuanwen , Betzen Bliss , Salcedo Andres , He Fei , Bowden Robert L. , Fellers John P. , Jordan Katherine W. , Akhunova Alina , Rouse Mathew N. , Szabo Les J. , Akhunov Eduard 
Published: October 2022

AbstractPuccinia graminis f.sp. tritici (Pgt) causes stem rust disease in wheat that can result in severe yield losses. The factors driving the evolution of its virulence and adaptation remain poorly characterized. We utilize long-read sequencing to develop a haplotype-resolved genome assembly of a U.S. isolate of Pgt. Using Pgt haplotypes as a reference, we characterize the structural variants (SVs) and single nucleotide polymorphisms in a diverse panel of isolates. SVs impact the repertoire of predicted effectors, secreted proteins involved in host-pathogen interaction, and show evidence of purifying selection. By analyzing global and local genomic ancestry we demonstrate that the origin of 8 out of 12 Pgt clades is linked with either somatic hybridization or sexual recombination between the diverged donor populations. Our study shows that SVs and admixture events appear to play an important role in broadening Pgt virulence and the origin of highly virulent races, creating a resource for studying the evolution of Pgt virulence and preventing future epidemic outbreaks.
Personalized risk predictor for acute cellular rejection in lung transplant using soluble CD31
Authors: Tran-Dinh Alexy , Laurent Quentin , Even Guillaume , Tanaka Sébastien , Lortat-Jacob Brice , Castier Yves , Mal Hervé , Messika Jonathan , Mordant Pierre , Nicoletti Antonino , Montravers Philippe , Caligiuri Giuseppina , Morilla Ian 
Published: October 2022

AbstractWe evaluated the contribution of artificial intelligence in predicting the risk of acute cellular rejection (ACR) using early plasma levels of soluble CD31 (sCD31) in combination with recipient haematosis, which was measured by the ratio of arterial oxygen partial pressure to fractional oxygen inspired (PaO2/FiO2) and respiratory SOFA (Sequential Organ Failure Assessment) within 3 days of lung transplantation (LTx). CD31 is expressed on endothelial cells, leukocytes and platelets and acts as a “peace-maker” at the blood/vessel interface. Upon nonspecific activation, CD31 can be cleaved, released, and detected in the plasma (sCD31). The study included 40 lung transplant recipients, seven (17.5%) of whom experienced ACR. We modelled the plasma levels of sCD31 as a nonlinear dependent variable of the PaO2/FiO2 and respiratory SOFA over time using multivariate and multimodal models. A deep convolutional network classified the time series models of each individual associated with the risk of ACR to each individual in the cohort.
Vitamin D status in chimpanzees in human care: a Europe wide study
Authors: Moittié Sophie , Jarvis Rachel , Bandelow Stephan , Byrne Sarah , Dobbs Phillipa , Grant Melissa , Reeves Christopher , White Kate , Liptovszky Mátyás , Baiker Kerstin 
Published: October 2022

AbstractWhile vitamin D deficiency is a public health concern in humans, comparatively little is known about vitamin D levels in non-human primates. Vitamin D plays a crucial role in overall health and its deficiency is associated with a range of disorders, including cardiovascular disease, which is a leading cause of death in great apes. Serum samples (n = 245) from chimpanzees (Pan troglodytes) housed at 32 European zoos were measured for 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and total 25-hydroxyvitamin D (25-OHD) using liquid chromatography and tandem mass spectrometry. Of these samples, 33.1% indicated inadequate vitamin D status, using the human reference interval (25-OHD < 50 nmol/L). The season of the year, health status of the animal, and the provision of daily outdoor access had a significant effect on vitamin D status. This is the first large-scale study on vitamin D status of non-human great apes in human care. Inadequate 25-OHD serum concentrations are widespread in the chimpanzee population in Europe and could be a risk factor for the development of idiopathic myocardial fibrosis, a major cause of mortality in this species, as well as other diseases. A review of husbandry and nutrition practices is recommended to ensure optimal vitamin D supply for these endangered animals.
Hybrid photon–phonon blockade
Authors: Abo Shilan , Chimczak Grzegorz , Kowalewska-Kudłaszyk Anna , Peřina Jan , Chhajlany Ravindra , Miranowicz Adam 
Published: October 2022

AbstractWe describe a novel type of blockade in a hybrid mode generated by linear coupling of photonic and phononic modes. We refer to this effect as hybrid photon–phonon blockade and show how it can be generated and detected in a driven nonlinear optomechanical superconducting system. Thus, we study boson-number correlations in the photon, phonon, and hybrid modes in linearly coupled microwave and mechanical resonators with a superconducting qubit inserted in one of them. We find such system parameters for which we observe eight types of different combinations of either blockade or tunnelling effects (defined via the sub- and super-Poissonian statistics, respectively) for photons, phonons, and hybrid bosons. In particular, we find that the hybrid photon–phonon blockade can be generated by mixing the photonic and phononic modes which do not exhibit blockade.