bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of peripapillary capillary plexus using optical coherence tomography angiography and retinal nerve fibre layer analysis using spectral domain optical coherence tomography in glaucoma patients, glaucoma suspects, and healthy subjects
Authors: Dutta Ananya , Thulasidas Mithun , Sasidharan Ajita , Pradeep Balam , Rajesh Prabu V 
Published: December 2022

Purpose:
To assess the association between radial peripapillary capillary (RPC) plexus using optical coherence tomography angiography (OCTA) and retinal nerve fibre layer (RNFL) thickness using spectral domain OCT (SD-OCT) in primary open-angle glaucoma (POAG) patients, glaucoma suspects, and healthy subjects.

Methods:
In this single-centre cross-sectional observational study, POAG, glaucoma suspects, and healthy patients underwent OCT-RNFL and optic nerve head angiography scans. The RNFL thickness and the vascular parameters obtained from RPC plexus, including perfusion density (PD), flux index (FI), and vessel density (VD), were analysed.

Results:
In all, 120 eyes of 120 patients, including 40 POAG patients, 40 glaucoma suspects, and 40 healthy subjects, were included. The pairwise comparison of mean RNFL thickness, FI, and VD showed significant difference (P < 0.001) in all sectors between POAG, glaucoma suspects, and healthy eyes. However, PD showed no significant difference between glaucoma suspects and healthy eyes. The average RNFL thickness was found to have a better diagnostic ability than VD to distinguish POAG eyes from healthy eyes and glaucoma suspects based on receiver operating characteristics curve and area under the curve. VD had better diagnostic accuracy than RNFL when glaucoma suspects and healthy were compared.

Conclusion:
OCT-RNFL has better diagnostic capability in differentiating glaucoma from healthy eyes compared to OCTA. However, OCTA was found to be better in screening out glaucoma suspects from healthy eyes. The VD is a better OCTA parameter than FI and PD to differentiate POAG and glaucoma suspects from healthy eyes.
Comparative evaluation of an automated preloaded delivery system with a non-preloaded system
Authors: Joshi Rajesh S 
Published: December 2022

Purpose:
To evaluate a single surgeon’s experience with an automated preloaded intraocular lens (IOL) delivery system and a nonpreloaded system.

Methods:
This was a prospective, observational case series. Phacoemulsification was performed under topical anesthesia by creating a temporal clear corneal incision. Patients were consecutively assigned to either the Clareon group (n = 50; the IOL was injected into the capsular bag by using an automated injector system) or the AcrySof group (n = 50; the IOL was injected into the capsular bag by using a conventional injector system). The main outcome measures were ease of implantation, intraoperative complications, postoperative centration, and visual acuity.

Results:
Additional manipulation in the anterior chamber was not required in 38 (74%) eyes in the Clareon group and 41 (82%) eyes in the AcrySof group. However, seven eyes in the Clareon group and one eye in the AcrySof group required trailing haptic dislodgement from the optic. Furthermore, two eyes in the Clareon group and five eyes in the AcrySof group required injector rotation (varying from 10° to 90°) in the wound. Moreover, in two eyes of the Clareon group, the silicon plunger of the injector system crossed over the optic. None of the patients developed iris trauma and PCR during IOL manipulation. All the IOLs were centered in the capsular bag.

Conclusion:
The automated IOL delivery system enables the controlled delivery of an IOL in the capsular bag. The effect of carbon footprints created by plastic generated from the delivery system and the implications of the CO2 cylinder on the environment should be addressed.
Diagnostic ability of superficial vascular density measured by optical coherence tomography angiography to differentiate high myopic eyes from eyes with primary open angle glaucoma
Authors: Santhosh Liz Mary , Elias Anna , Anup Manju , Nair Abhilash , Anantharaman Giridhar , Prakash Nimmi 
Published: December 2022

Purpose:
To determine if high myopia and glaucoma can be differentiated based on the measurement of superficial vascular density in the peripapillary and macular areas by using Optical Coherence Tomography Angiography (OCTA).

Methods:
This prospective, observational, cross-sectional, comparative study was conducted on patients between 40 and 60 years of age diagnosed as primary open-angle glaucoma (POAG) or high myopia and compared with age-matched controls. The main outcome measures were the difference in SVD% in peripapillary and macular areas in POAG and high myopic eyes. Detailed ophthalmic examination and OCTA of the disc and peripapillary area and macula were performed. The SVD in each zone was calculated using ImageJ software and their difference were analyzed.

Results:
In total, 128 eyes of 70 patients were enrolled. Peripapillary SVD% in controls was 45.07 ± 3.44, 40.36 ± 8.27 in high myopia, and 31.80 ± 9.008 in POAG. The mean difference in peripapillary SVD% of POAG to control was − 13.479, of POAG to high myopia was −8.777 (both P < 0.001), and of high myopia to controls was −4.701 (P = 0.012). Macular SVD% in controls was 27.30 ± 3.438, 22.33 ± 6.011 in high myopia, and 21.21 ± 5.598 in POAG. The mean difference in macular SVD% of POAG to controls was −6.088, of high myopia to controls was −4.965 (both P < 0.001), and of POAG to high myopia was −1.122 (P = 0.984; not statistically significant).

Conclusion:
OCTA is a useful diagnostic tool in distinguishing glaucomatous and myopic eyes. The measurement of peripapillary SVD has a greater discriminatory ability than that of the macular area.
Comparison of stereoacuity in patients of anisometropia, isometropia and emmetropia
Authors: Khan Nida , Zaka-ur-Rab Simi , Ashraf Mohammad , Mishra Aradhna 
Published: December 2022

Purpose:
To compare the stereoacuity in patients with anisometropia, isometropia, and emmetropia.

Methods:
A cross-sectional study was conducted on 1403 subjects (range: 5–45 years) divided into anisometropes (n = 403), isometropes (n = 500), and emmetropes (n = 500). There were 258 amblyopic eyes among anisometropes and 156 amblyopic eyes among isometropes. Stereoacuity was measured using the Titmus stereo test consisting of a combination of contour targets.

Results:
There were 675 males and 728 females. A significant (P < 0.001) reduction in stereoacuity was found in anisometropes as compared to isometropes and emmetropes. The stereoacuity was even worse in amblyopes as compared to non-amblyopes. Most patients with anisometropia of <3.0 D had fair stereoacuity. However, as the degree of anisometropia increased to >3.0 D, stereoacuity deteriorated gradually. Marked reduction of stereoacuity was observed in severe degree of anisometropia (>6.0 D). Overall, an anisometropia of ≥2.12 D was associated with reduced stereoacuity. Among the anisometropes, it was found to be the poorest in myopia, followed by myopia with astigmatism, hypermetropia with astigmatism, and hypermetropia.

Conclusion:
The level of stereoacuity was worse in anisometropes as compared to isometropes and emmetropes. Amblyopes had a greater reduction in stereoacuity than non-amblyopes. Stereoacuity decreased as the degree of anisometropia increased. Among the anisometropes, myopes had worst stereoacuity than hypermetropes.
Clinical outcomes of femtosecond laser–assisted cataract surgery versus conventional phacoemulsification: A retrospective study in a tertiary eye care center in South India
Authors: Medhi Santana , Senthil Prasad R , Pai Aruna , Muthukrishnan Gomathi Ramya , Mariammal A , Chitradevi R , Shekhar Madhu 
Published: December 2022

Purpose:
To compare the clinical outcomes of femtosecond laser–assisted cataract surgery (FLACS) versus conventional phacoemulsification (CP) in terms of refractive outcomes, cumulative dissipated energy, and intraoperative complications.

Methods:
In this retrospective study performed in a tertiary care ophthalmic hospital, we reviewed 2124 eyes that underwent FLACS or CP. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), cumulative dissipated energy (CDE), and intraoperative complications were analyzed in the study.

Results:
Out of 2124 eyes, 873 underwent FLACS and 1251 underwent CP. The postoperative mean UCVA after one month was 0.05 ± 0.11 logMAR and 0.14 ± 0.23 logMAR for FLACS and CP, respectively (P < 0.00001). Mean CDVA one month post operation was 0.02 ± 0.07 logMAR and 0.06 ± 0.19 logMAR for FLACS and CP, respectively (P < 0.0001). The CDE for the FLACS group was 6.17 ± 3.86 (P < 0.00001) and it was 9.74 ± 6.02 for the CP group. The intraoperative complication for the FLACS group was 1.60% and the CP group was 2.39% (P < 0.00001).

Conclusion:
The visual outcomes were better in FLACS compared to CP. The CDE was lower for the FLACS group and FLACS had significantly less intraoperative complications.
Evaluation of antifungal susceptibility and clinical characteristics in fungal keratitis in a tertiary care center in North India
Authors: Vanathi Murugesan , Naik Ravinder , Sidhu Navneet , Ahmed Nishat Hussain , Gupta Noopur , Tandon Radhika 
Published: December 2022

Purpose:
To study the antifungal susceptibility of common corneal pathogenic fungi to antifungal agents in the North Indian population.

Methods:
Prospective study of the antifungal sensitivity testing (natamycin, amphotericin B, voriconazole, itraconazole, fluconazole, posaconazole, caspofungin, micafungin) of fungal isolates from 50 cases of culture positive fungal keratitis by using E test method. Details noted included demographic data, visual acuity, clinical details, grade of keratitis, healing time, and success in medical management.

Results:
Of 50 patients with fungal keratitis (mean age: 40.28 ± 16.77 years), 12 eyes healed within 3 weeks, 14 had a delayed healing response, and 24 had chronic keratitis. Among the 15 cases of Fusarium isolates, 93.3% were sensitive to natamycin, while 40% to amphotericin B; 66.6% to voriconazole, 13.4% to itraconazole and fluconazole each. 80% of Fusarium cases (n = 12) showed susceptibility to posaconazole. Among Aspergillus flavus isolates, 53.4% (n = 8) were sensitive to natamycin, with only 40% (n = 7) showing sensitivity to amphotericin B and good susceptibility to azoles. MIC against susceptible Fusarium spp. for natamycin was 3–16 µg/mL, amphotericin B: 1–8 µg/mL, voriconazole: 0.5–1.5 µg/mL, itraconazole: 0.5–12 µg/mL, posaconazole: 0.094–1.5 µg/mL. MIC against Aspergillus flavus was natamycin: 8–32 µg/mL, amphotericin B: 0.5–16 µg/mL, voriconazole: 0.025–4 µg/mL, itraconazole: 0.125–8 µg/mL, posaconazole: 0.047–0.25 µg/mL; against Aspergillus niger isolates, to natamycin was 6 µg/mL (n=1), amphotericin B 8–12 µg/mL (n = 3), voriconazole: 0.125–0.19 µg/mL (n = 3), itraconazole: 0.38–0.75 µg/mL, posaconazole: 0.064–0.19 µg/mL and against Aspergillus fumigatus (n = 1), was natamycin4 µg/mL, amphotericin B - 8 µg/mL, voriconazole 0.25 µg/mL, itraconazole 1 µg/mL, and posaconazole 0.19 µg/mL. MIC against susceptible Acremonium spp. for natamycin was 1.5–16 µg/mL, amphotericin B: 0.5–8 µg/mL, voriconazole: 0.19–3 µg/mL, itraconazole: 0.125 µg/mL, posaconazole: 0.125–0.5 µg/mL and against susceptible Curvularia was natamycin 0.75–4 µg/mL, amphotericin B 0.5–1 µg/mL, voriconazole 0.125–0.19 µg/mL, itraconazole 0.047–0.094 µg/mL, posaconazole 0.047–0.094 µg/mL. MIC against Mucor spp.+ Rhizopus spp. (n = 1) was natamycin: 8 µg/mL, amphotericin B: 0.75 µg/mL, posaconazole: 1.5 µg/mL. MIC against of Alternaria (n = 1) was voriconazole: 0.19 µg/mL, posaconazole: 0.094 µg/mL. MIC against Penicillium (n=1) was natamycin: 8 µg/mL, voriconazole: 0.25 µg/mL, itraconazole: 0.5 µg/mL, and Posaconazole: 0.125 µg/mL.

Conclusion:
Our observations highlight the variations in susceptibility to antifungal agents. Posaconazole seems to be effective with low MIC against common corneal pathogenic fungal isolates.
Genotype Profiles of Rotavirus Strains in Children under 5-year-old Outpatients with Diarrhea in Bandung, West Java, Indonesia
Authors: Prasetyo Dwi , Ermaya Yudith Setiati , Sabaroedin Iesje Martiza , Widhiastuti Dyah , Bachtiar Novilia Sjafri , Kartasasmita Cissy Bana 
Published: December 2022

Introduction:
Diarrhea is a global leading cause of morbidity and mortality among children under five, with rotaviruses being the most common cause. This study aimed to determine the genotypes of rotavirus in children under 5 years with diarrhea in Bandung, Indonesia.

Methods:
This cross-sectional study was conducted from 2014 to 2018 on 450 children under five with acute diarrhea in primary health centers in Bandung, Indonesia. Fecal samples were examined for rotavirus antigen using an enzyme-linked immunosorbent assay method, and genotype was determined through sequencing using polymerase chain reaction. Results were statistically analyzed using Pearson Chi-square in Epi Info version 3.5.4, with P < 0.05 considered statistically significant.

Results:
Rotavirus was identified in 8.9% of the subjects, slightly higher in boys (n = 24, 9.8%) than girls (n = 16, 7.8%). We found that the most rotavirus positive in age group is >12–24 months and >24–59 months, while the highest percentage is at the age of ≤6 months (11.8%). Moderate malnutrition was observed in more subjects (12.8%). Vomiting was more frequent in patients positive (55%, P = 0.013) and fever was seen in 32.5% (P = 0.645). No signs of dehydration were seen in most subjects (75%), P = 0.227. Rotavirus genotypes identified were G1P[8] (18, 45%), G3P[8] (14, 35%), G3P[6] (4, 10%), G3P[9] (2, 5%), G2P[4] (1, 2.5%), and nontypeable (NT) (1, 2.5%).

Conclusions:
The dominant rotavirus genotype is G1P[8], followed by G3P[8], G3P[6], G3P[9], G2P[4], and NT. The most common rotavirus positive in age group is >12–24 months and >24–59 months, while the highest percentage is at the age of ≤6 months.
Quality of life after laparoscopic sleeve gastrectomy: Pre-operative, 1-year and 5-year results
Authors: Mouawad Christian , Aoun Rany , Dahboul Houssam , El Feghali Elie , Kassar Serge , Alkassis Marwan , Osseis Michael , Noun Roger , Chakhtoura Ghassan 
Published: December 2022

Introduction:
The negative impact of obesity on the quality of life (QoL) and its association with multiple comorbidities is unquestionable. The primary objective of this study was to compare the QoL of patients before, 1 year and 5 years after laparoscopic sleeve gastrectomy (LSG). Secondary objectives were to evaluate the resolution of obesity-related comorbidities and weight loss success.

Materials and Methods:
We included patients who underwent LSG for body mass index (BMI) ≥30 kg/m2 between August 2016 and April 2017 and completed the Moorehead-Ardelt QoL Questionnaire II (MA II). Statistical analysis was conducted using SPSS IBM Statistics for Windows version 21.

Results:
In total, 64 patients participated with a female majority (73.44%) and a mean age of 36.09 with an average BMI at 40.47. Percentage of excess BMI loss and excess weight loss (% EWL) at one and 5 years after surgery went from 90.18% to 85.05% and 72.17% to 67.09%, respectively. The total MA II score before LSG was − 0.39 ± 0.94. Postoperatively, it increased to 1.73 ± 0.60 at 1 year and 1.95 ± 0.67 at 5 years. The positive impact of LSG on QoL was more significant in patients presenting ≥30% of weight loss and in females. At 5 years, a significant improvement in many comorbidities was noted except for arterial hypertension, coxalgia, gastro-oesophageal reflux disease and lower extremities’ varices.

Conclusion:
LSG maintains a long-term QoL improvement, a significant EWL and a resolution of the most common obesity-associated comorbidities such as diabetes, dyslipidaemia and symptoms related to sleep apnoea.
The Effect of the Managing Examinatıon Anxiety Program Applied to High School Students on Test Anxiety
Authors: ÇİYDEM Emre , ŞAVKLI Yücel 
Published: December 2022

Aim: To examine the effect of the multimodal managing examination anxiety program applied to high school students on test anxiety of high school students and some predictors of test anxiety.
Material and Methods: The population of the study, which was in the pretest-posttest single-group quasi-experimental design, consisted of 150 high school senior students. A managing examination anxiety program applied once a week for 7 weeks to 40 students selected using the convinient sampling. The ınformation form and the Westside test exam scale used as data collection tools.
Results: The posttest mean score (32.15 ± 8.15) of the students from the Westside Test Exam Scale was significantly lower than the pretest mean score (37.57 ± 5.49) (p
“PAISAGEM LITORÂNEA”:
Authors: Pinto Carlos Rafael 
Published: December 2022

No presente ensaio teológico, propomos a metáfora de “paisagem litorânea”. Com ela, pretendemos discorrer sobre a proximidade, bem como sobre a relação e a comunhão entre Deus e o ser humano, segundo a leitura de Eugenio Rivas do pensamento de Maurice Blondel. Se, por um lado, na revelação cristã, Deus se comunica, doa a Si mesmo gratuita e amorosamente, como dom sobrenatural, ao ser humano, por outro, este, como ser finito e, ao mesmo tempo, aspirante ao infinito, apresenta-se em estado transnatural, estado de espera e recepção do mistério do dom superior. A recorrência à metáfora se faz importante pois, da mesma maneira que a “paisagem litorânea” requer a presença da praia, imagem da finitude, e do mar, imagem do infinito, a comunhão com Deus supõe a própria graça divina e a vida humana. Assim, a comunhão com o dom sobrenatural faz com que o ser humano se expanda de tal modo que experiencie aquilo a que insaciavelmente aspira: o infinito.
Palavras-chave: Deus. Infinito. Dom. Ser Humano. Paisagem Litorânea.
Analisis Kebermanfaatan Kurikulum Diklat Teknis Substantif Media Pembelajaran Berbasis Multimedia di Kementerian Agama Kabupaten Kupang
Authors: Agustini Ni Made Sri 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui kebermanfaatan kurikulum mata diklat inti dalam Diklat Teknis Substantif Media Pembelajaran Berbasis Multimedia di wilayah kantor Kementerian Agama Kabupaten Kupang dan untuk mengetahui jenis materi pelatihan multimedia yang sangat dibutuhkan oleh guru yang berada di daerah minim akses jaringan internet dalam meningkatkan profesionalitas dan tupoksi sebagai tenaga pendidik. Metode yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan teknik pengumpulan data melalui kuesioner dan observasi. Disimpulkan bahwa kurikulum mata diklat inti dalam Diklat Media Pembelajaran Berbasis Multimedia memiliki tingkat kebermanfaatan 82% dengan kategori bermanfaat. Kurikulum belum sepenuhnya sesuai dengan kebutuhan guru yang berada dalam daerah minim akses sinyal internet di wilayah Kantor Kementerian Agama Kabupaten Kupang. Materi pelatihan multimedia yang sangat dibutuhkan oleh guru yang berada di daerah minim akses jaringan internet dalam meningkatkan profesionalitas dan tupoksi sebagai tenaga pendidik di wilayah Kantor Kementerian Agama Kabupaten Kupang adalah Microsoft Powerpoint dan Macromedia Flash. Kurikulum Diklat Teknis Media Pembelajaran Berbasis Multimedia perlu dikaji ulang berdasarkan peta topografi ketersediaan jaringan internet dan kurikulum dapat dimodifikasi antara berbasis offline dan online sehingga dapat memanfaatkan aplikasi perancangan media pembelajaran berbasis Multimedia ter-update.
This research purposed to determine the usefulness of main materials curriculum training program of Substantive Technical Education and Training of Multimedia-based learning media in the area of ​​Kupang regency Ministry of Religious Affair and to find out the types of Multimedia training materials that highly needed by teachers in areas with minimal internet access to improve professionalism and duty as educators. The method used in this study was descriptive quantitative with data collection techniques through questionnaires and observations. From data analysis were concluded that the main materials Curriculum in Multimedia-based Learning Training Media had grade of usefulness 82% with useful categories. The curriculum is not fully suitable with the needs of teachers in areas with minimal internet signal access in Ministry of Religious Affair at Kupang regency Area. Multimedia training material that were greatly needed by teachers in areas with minimal internet access in increasing professionalism and duties as educators in Kupang Regency Ministry of Religious Affair area were Microsoft PowerPoint and Macromedia Flash. Curriculum of Technical Training Media Multimedia-based learning needs to be reviewed based on topographic maps. The availability of the Internet Network and curriculum can be modified between offline and online based, so the materials can utilize the application of updated Multimedia-based learning media design.
APLIKASI VISUAL SEJARAH MAKAM RADEN AYU SITI KHOTIJAH SEBAGAI PENGUATAN MODERASI BERAGAMA DI KALANGAN MILENIAL
Authors: Suciartini Ni nyoman ayu suciartini 
Published: December 2022

Kementerian Agama mendorong penguatan moderasi beragama di Indonesia. Moderasi beragama dapat dipahami sebagai cara pandang, sikap dan perilaku selalu mengambil posisi di tengah-tengah, selalu bertindak adil dan tidak ekstrim dalam beragama. Moderasi beragama kunci terciptanya toleransi dan kerukunan. Pengenalan moderasi beragama dapat disajikan secara digital salah satunya dengan dihadirkannya media interaktif aplikasi visual makam Rade Ayu Siti Khotijah yang informatif dan edukatif. Visual novel merupakan sebuah jenis permainan yang dapat dimainkan di personal computer (PC) pada awalnya dan telah menjadi permainan offline. Permainan ini berbasis petualangan yang difokuskan di bagian penceritaan dengan elemen-elemen pendukungnya seperti gambar beserta teks dan suara. Sebuah visual novel bisa dapat menarik minat untuk mengetahui dan memahami suatu tema yang diangkat pada sejarah. Visual atau aplikasi visual yang mengangkat cerita terkait makam Raden Ayu Siti Khotijah yang akan menjadi media moderasi beragama di kalangan generasi milenial, terutamanya diperkenalkan di kampus atau di tingkat sekolah menengah atas. Dalam penjaringan data berupa wawancara dan penyebaran kuesioner terbuka kepada dua puluh responden disimpulkan bahwa aplikasi visual yang berisi sejarah makam Raden Ayu Siti Khotijah ini mengandung nilai edukatif dan sekaligus menjadi media sosialisasi positif terkait moderasi beragam kepada kaum milenial. Responden memberikan tanggapan beragam terkait empat indikator seseorang dikatakan moderat dalam upaya moderasi beragama di tengah kemajemukan bangsa. Empat indikator moderasi beragama yaitu (1) komitmen kebangsaan, (2) toleransi, (3) anti-kekerasan, dan (4) akomodatif terhadap kebudayaan lokal.

Kata Kunci: Moderasi Beragama, aplikasi visual, Makam Raden Ayu Siti Khotijjah