bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological disparity in extant and extinct sepiid phragmocones: morphological adaptions for phragmocone strength compared to those related to cameral liquid emptying hypotheses
Authors: Ward Peter D. , Veloso Job Lukas , Klug Christian 
Published: May 2022

AbstractThe phragmocone-bearing coleoid cephalopodsSepia,Sepiella,MetasepiaandHemisepius(sepiids) are the most diverse of all extant chambered cephalopods and show the highest disparity. As such, they have a great potential to serve as model organisms to better understand the paleobiology not only of extinct coleoids, but of extinct nautiloids and ammonoids as well. Here, we present new measurements from the phragmocones ofSepiaandSepiellaand relate these to known maximum depths. While these latter data remain few for some species, in aggregate they provide progress allowing this work. In so doing, we expand upon the great legacy of Sigurd von Boletzky. We show that deep water-inhabiting sepiids have phragmocones with a higher number of septa per length, a smaller area covered by the last chamber in relation to the volume of all previous phragmocone chambers, are smaller in size (length and volume), and bear dorsal shields that have strengthening central rib(s) compared to most species from shallower water; the very small endemic species of South Africa may be an exception. We show that the various subgenera defined by Khromov (1987) are not monophyletic clades but morphological groupings explicitly related to depth, partially evolved convergently. We conclude with analyses of Australian sepiid assemblages and show that these are depth related in ways analogous to ammonite and/or nautiloid assemblages of the past that are later commingled through post-mortal drift.
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells
Authors: Ma Xueyou , Tan Zenglai , Zhang Qin , Ma Kaifang , Xiao Jun , Wang Xiong , Wang Yanan , Zhong Mengjie , Wang Yu , Li Jing , Zeng Xing , Guan Wei , Wang Shaogang , Gong Kan , Wei Gong-Hong , Wang Zhihua 
Published: May 2022

Abstract
Background
Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or malignant tumors. The mechanism of VHL mutants in pathogenicity is poorly understand.

Results
Here we identified heterozygous missense mutations c.193T > C and c.194C > G in VHL in several patients from two Chinese families. These mutations are predicted to cause Serine (c.193T > C) to Proline and Tryptophan (c.194C > G) substitution at residue 65 of VHL protein (p.Ser65Pro and Ser65Trp). Ser65 residue, located within the β-domain and nearby the interaction sites with hypoxia-inducing factor α (HIFα), is highly conserved among different species. We observed gain of functions in VHL mutations, thereby stabilizing HIF2α protein and reprograming HIF2α genome-wide target gene transcriptional programs. Further analysis of independent cohorts of patients with renal carcinoma revealed specific HIF2α gene expression signatures in the context of VHL Ser65Pro or Ser65Trp mutation, showing high correlations with hypoxia and epithelial-mesenchymal transition signaling activities and strong associations with poor prognosis.

Conclusions
Together, our findings highlight the crucial role of pVHL-HIF dysregulation in VHL disease and strengthen the clinical relevance and significance of the missense mutations of Ser65 residue in pVHL in the familial VHL disease.
A new subgradient extragradient method for solving the split modified system of variational inequality problems and fixed point problem
Authors: Sripattanet Anchalee , Kangtunyakarn Atid 
Published: May 2022

AbstractWe introduce a new subgradient extragradient algorithm utilizing the concept of the set of solutions of the split modified system of variational inequality problems (SMSVIP). Our main theorem is weak convergence theorem for such an algorithm for approximating the fixed point problem in a real Hilbert space. We also apply these results to approximate the split minimization problem. In the last section, we provide an example to illustrate the potential of our main theorem.
Existence and blow-up of weak solutions of a pseudo-parabolic equation with logarithmic nonlinearity
Authors: Lakshmipriya N. , Gnanavel S. , Balachandran K. , Ma Yong-Ki 
Published: May 2022

AbstractIn this paper, we prove the existence of weak solutions of a pseudo-parabolic equation with logarithmic nonlinearity in an interval $[0, T)$
[
0
,
T
)
by employing the Galerkin approximation method and compactness arguments. We show that the solutions become unbounded at a finite time $T^{\star}$

T
⋆

and find upper and lower bounds for this time.
Starchy and fibrous feedstuffs differ in their in vitro digestibility and fermentation characteristics and differently modulate gut microbiota of swine
Authors: Tiwari Utsav P. , Mandal Rabindra K. , Neupane Kabi Raj , Mishra Birendra , Jha Rajesh 
Published: May 2022

Abstract
Background
Alternative feedstuffs may contribute to reducing feed costs of pig production. But these feedstuffs are typically rich in fiber and resistant starch (RS). Dietary fibers and RS are fermented in the gastrointestinal tract (GIT) and modulate the microbial community. Certain microbes in the GIT can promote host health, depending on the type of fermentation substrates available. In this study, six alternative feedstuffs (three starchy: Okinawan sweet potato, OSP; yam, and taro, and three fibrous: wheat millrun, WMR; barley brewers grain, BBG; and macadamia nut cake, MNC) were evaluated for their in vitro digestibility and fermentation characteristics and their effects on pig’s hindgut microbial profile. After 2 steps of enzymatic digestion assay, residues were fermented using fresh pig feces as microbial inoculum, and gas production was recorded periodically for 72 h and modeled for fermentation kinetics. After fermentation, the residual liquid phase was analyzed for short-chain fatty acid (SCFA), and the solid phase was used to determine the nutrient’s digestibility and microbial community.

Results
In vitro ileal digestibility of dry matter and gross energy was higher in starchy than fibrous feedstuffs. Total gas and SCFA production were significantly higher (P < 0.001) in starchy feedstuffs than fibrous feedstuffs. Both acetate and propionate production was significantly higher (P < 0.001) in all starchy feedstuffs than BBG and MNC; WMR was in between. Overall alpha diversity was not significantly different within and between starchy and fibrous feedstuffs. Beta diversity (measured using bray Curtis dissimilarity distance) of starchy feedstuffs was significantly different (P < 0.005) than fibrous feedstuffs.

Conclusion
Starchy feedstuffs acted as a substrate to similar types of microbes, whereas fibrous feedstuffs resulted in a more diverse microbial population. Such alternative feedstuffs may exert comparable beneficial effects, thus may be included in swine diets to improve gut health.
A comprehensive model to predict severe acute graft-versus-host disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation
Authors: Shen Meng-Zhu , Hong Shen-Da , Lou Rui , Chen Rui-Ze , Zhang Xiao-Hui , Xu Lan-Ping , Wang Yu , Yan Chen-Hua , Chen Huan , Chen Yu-Hong , Han Wei , Wang Feng-Rong , Wang Jing-Zhi , Liu Kai-Yan , Huang Xiao-Jun , Mo Xiao-Dong 
Published: May 2022

Abstract
Background
Acute graft-versus-host disease (aGVHD) remains the major cause of early mortality after haploidentical related donor (HID) hematopoietic stem cell transplantation (HSCT). We aimed to establish a comprehensive model which could predict severe aGVHD after HID HSCT.

Methods
Consecutive 470 acute leukemia patients receiving HID HSCT according to the protocol registered at https://clinicaltrials.gov (NCT03756675) were enrolled, 70% of them (n = 335) were randomly selected as training cohort and the remains 30% (n = 135) were used as validation cohort.

Results
The equation was as follows: Probability (grade III–IV aGVHD) = $$\frac{1}{{1 + \exp \left( { - \,{\text{Y}}} \right)}}$$

1

1
+
exp

-

Y

, where Y = –0.0288 × (age) + 0.7965 × (gender) + 0.8371 × (CD3 + /CD14 + cells ratio in graft) + 0.5829 × (donor/recipient relation) − 0.0089 × (CD8 + cell counts in graft) − 2.9046. The threshold of probability was 0.057392 which helped separate patients into high- and low-risk groups. The 100-day cumulative incidence of grade III–IV aGVHD in the low- and high-risk groups was 4.1% (95% CI 1.9–6.3%) versus 12.8% (95% CI 7.4–18.2%) (P = 0.001), 3.2% (95% CI 1.2–5.1%) versus 10.6% (95% CI 4.7–16.5%) (P = 0.006), and 6.1% (95% CI 1.3–10.9%) versus 19.4% (95% CI 6.3–32.5%) (P = 0.017), respectively, in total, training, and validation cohort. The rates of grade III–IV skin and gut aGVHD in high-risk group were both significantly higher than those of low-risk group. This model could also predict grade II–IV and grade I–IV aGVHD.

Conclusions
We established a model which could predict the development of severe aGVHD in HID HSCT recipients.
The five tenets of family-based treatment for adolescent eating disorders
Authors: Rienecke Renee D. , Le Grange Daniel 
Published: May 2022

AbstractFamily-based treatment (FBT) is the leading treatment for adolescent eating disorders and is based on five tenets, or fundamental assumptions: (1) the therapist holds an agnostic view of the cause of the illness; (2) the therapist takes a non-authoritarian stance in treatment; (3) parents are empowered to bring about the recovery of their child; (4) the eating disorder is separated from the patient and externalized; and (5) FBT utilizes a pragmatic approach to treatment. Learning these tenets is crucial to the correct practice and implementation of manualized FBT. The purpose of the current paper is to provide an in-depth overview of these five tenets and to illustrate how they are used in clinical practice. This overview will aid clinicians who are learning FBT.
Computational methods for predicting the outcome of thoracic transplantation
Authors: Raji C. G. , Safna A. K. 
Published: May 2022

AbstractCardiac disease and the death rates due to coronary heart failure and cardiomyopathy are increasing. Thoracic transplantation is now a widely accepted therapeutic option for end-stage cardiac failure. The survival rate after the organ transplantation is crucial. Survival prediction after heart transplantation is a hot area of research. The use of conventional statistical techniques is computationally expensive and does not provide reliable solutions. Artificial Neural Networks based survival prediction helps surgeons make precise decisions and predict the best outcomes. The proposed system implements multi-layer perceptron algorithm, which shows good performance in survival prediction. We also implemented our work in the Radial Basis Function Network model to prove the accuracy of proposed model. For this research study, data were collected from United Network for Organ Sharing database and extracted the relevant thoracic transplantation survival prediction attributes with the help of suitable data mining techniques. We obtained an accuracy of 97.1% from the multi-layer perceptron model with the evaluation of various performance measures. In order to assure the validity of the proposed model we implemented the Radial Basis Function model and obtained an accuracy of 92.37%. We collated the accuracy of proposed survival prediction models with existing systems and proved that the proposed system appeared to be best for survival prediction with higher accuracy compared to 85.9% in the existing system. The outcome of the model will be an asset for the lifesaving procedures in the medical field.
A unified representation and transformation of multi-model data using category theory
Authors: Koupil Pavel , Holubová Irena 
Published: May 2022

AbstractThe support for multi-model data has become a standard for most of the existing DBMSs. However, the step from a conceptual (e.g., ER or UML) schema to a logical multi-model schema of a particular DBMS is not straightforward. In this paper, we extend our previous proposal of multi-model data representation using category theory for transformations between models. We introduce a mapping between multi-model data and the categorical representation and algorithms for mutual transformations between them. We also show how the algorithms can be implemented using the idea of wrappers with the interface published but specific internal details concealed. Finally, we discuss the applicability of the approach to various data management tasks, such as conceptual querying.
Knowledge, attitude, and practice of pharmacists regarding asthma management: a cross-sectional study in Egypt
Authors: Said Amira S. A. , Hussain Nadia , Kharaba Zelal , Al Haddad Amal H. I. , Abdelaty Lamiaa N. , Hussein Raghda R. S. 
Published: May 2022

Abstract
Background
Asthma is a significant public health issue that poses a substantial health and economic burden. Despite the availability of effective asthma medications, its management remain suboptimal. Recent asthma guidelines have highlighted the importance of pharmacist unique position and its interventional strategies in positively impacting asthma treatment outcomes. Therefore, this study aimed to assess the degree of Egyptian pharmacists’ knowledge, attitudes, as well as their practices towards asthma management in line with the recent asthma guidelines.

Methods
This cross-sectional study was conducted among 800 pharmacists working in different private and governmental sectors. The data were collected using a 37-item pre-validated self-administered KAP questionnaire. The data were analyzed using Student’s t-test and analysis of variance to assess the association between each KAP level and the sociodemographic variables at the significance level of 0.05.

Results
Of the 800 distributed questionnaire, a total of 550 participants (316 Male, and 234 Female) responded, representing a 68.7% response rate. The mean ± SD score of knowledge, attitude, practice, and barrier was 5.49 ± 1.65 (min = 0; max = 8), 23.5 ± 2.84 (min = 15, max = 30), 43.12 ± 8.61 (min = 28, max = 62), and 27.76 ± 3.72 (min = 17, max = 39), respectively. The results showed that poor knowledge, attitude, and practice scores were achieved by 30.54, 0, and 38.72% of participants, respectively.

Conclusion
Our findings revealed the inconsistencies between poor pharmacists’ knowledge and practices with respect to their positive attitudes. The lack of pharmacists’ knowledge and compliance to recent GINA guidelines in this study highlight the crucial need for effective Educational strategies that should better equip pharmacists for their potential role in asthma care.
What is the impact of dynamic contrast-enhancement sequence in the Vesical Imaging, Reporting and Data System (VI-RADS)? A subgroup analysis
Authors: Bricio Thaisa Gvozdenovic Medina , Gouvea Gabriel Lion , Barros Rafael Vasconcelos , Chahud Fernando , Elias Jorge , Reis Rodolfo B. , Muglia Valdair F. 
Published: May 2022

Abstract
Background
A scoring system focusing on the risk of muscle layer invasion by Bladder cancer (BCa) has been released, Vesical Imaging - Radiological and Data System (VI-RADS), with a growing interest in evaluating its diagnostic accuracy.
Our goal was to assess the accuracy and reproducibility of the VI-RADS score for assessment of the vesical muscular layer with (multiparametric-mp) and without (biparametric-bp) a dynamic-contrast enhancement (DCE) sequence.

Methods
Retrospective study conducted from July 2018 to July 2020. All patients had suspicions of BCa and underwent Magnetic Resonance Imaging (MRI) before any intervention. MRI was interpreted by two radiologists with different levels of experience, and a VI-RADS score assigned in two different sessions (3 months apart) without and with DCE. After exclusions, 44 patients with 50 lesions were enrolled. The standard of reference was transurethral resection in 18 patients (40.9%) and cystectomy in 26 patients (59.1%).

Results
Twenty-five lesions (50%) were muscle-invasive. There was no significant difference between the two groups for gender and presence of a stalk, but mean age of NMIBCa group was significantly higher (p = 0.01). The sizes of lesions were significantly different between groups for both readers at 2.42+/− 1.58 vs. 5.70+/− 2.67 cm for reader 1 (p < 0.0001) and 2.37+/− 1.50 vs. 5.44 +/− 2.90 cm for reader 2 (p = 0.001). The area under the curve (AUC) for muscle invasion with mpVI-RADS, considering all lesions, was 0.885 +/− 0.04 (95% CI-0.79-0.98) for reader 1 and 0.924 +/− 0.04 (0.84–0.99) for reader 2, and for bpVI-RADS was 0.879+/− 0.05 and 0.916 +/− 0.04 (0.85–0.99), respectively, both differences not statistically significant (p = 0.24 and 0.07, respectively). When considering only small lesions (< 3.0 cm), the accuracy for mpVI-RADS was 0.795 +/− 0.11 (0.57–1.0) for reader1, and 0.80 +/− 0.11(0.57–1.0) for reader 2, a non-significant difference (p = 0.56) and for bpVI-RADS was 0.747 +/− 0.12 (0.50–0.99) for reader 1 and 0.80 +/− 0.11(0.57–1.0) for reader 2, a significant difference (p = 0.04). The intraclass correlation coefficient for the final score was 0.81 (0.60–1.0) for mpVI-RADS and 0.85 (0.63–1.0) for bpVI-RADS.

Conclusion
The VI-RADS system was accurate in demonstrating muscle-invasive BCa, for both experienced and less experienced reader, regardless of the use of a DCE sequence. However, when only small lesions were assessed the difference between the two readers was significant only for the biparametric analysis. The reproducibility was similar between multiparametric and biparametric approach.
Acetaminophen-induced hypotension in sepsis
Authors: Inage Shunsuke , Yajima Ryo , Nagahara Shintaro , Kazama Aya , Takamura Moe , Shoji Tomohiro , Kadoi Mika , Tashiro Yukiko , Ise Yuya 
Published: May 2022

Abstract
Background
Acetaminophen-induced hypotension has been reported in critically ill patients; however, it remains unclear whether mannitol, present as a stabilizing compound in acetaminophen formulations, affects hemodynamic changes. The objectives of this study were to clarify the direct effect of acetaminophen on blood pressure by comparing blood pressure changes after acetaminophen and intravenous immunoglobulin (IVIG) administration, both containing mannitol, in patients with sepsis and understand the risk factors for reduced blood pressure following acetaminophen administration.

Methods
This was a retrospective cohort study. Adult patients who were diagnosed with sepsis at Nippon Medical School Hospital, and who were undergoing continuous arterial blood pressure measurement and received intravenous acetaminophen or IVIG, were included.

Results
Overall, 185 patients were included, with 92 patients in the IVIG group and 93 in the acetaminophen group. The incidence of hypotension was 36.9% in the IVIG group (34 of 92 patients) and 58.0% in the acetaminophen group (54 of 93 patients) (OR = 8.26, p = 0.004). In a propensity score-matched cohort, 80 matched patients were selected. The incidence of hypotension was 37.5% in the IVIG group (15 of 40 patients) and 67.5% in the acetaminophen group (27 of 40 patients) (OR = 7.21, p = 0.007).

Conclusions
Acetaminophen induced substantially greater hypotension than IVIG in patients with sepsis, with both containing mannitol. Further studies are needed to clarify the effects on hemodynamics of mannitol contained in acetaminophen formulations.
Successful management of a mediastinum abscess with sternum destruction caused by MSSA bloodstream infection
Authors: Wada Hironobu , Shina Yuki , Kamata Toshiko , Ishibashi Fumihiro , Tamura Hajime , Toriumi Masahiro , Matsuzaki Kyoichi , Yoshida Shigetoshi 
Published: May 2022

Abstract
Background
Multiple deep organ abscesses associated with Staphylococcus aureus bloodstream infection (SAB) have a high mortality rate, requiring rapid removal or drainage of infective foci with long-term appropriate antimicrobial therapy. Cases in which infective foci cannot be completely removed are challenging for their management.

Case presentation
A 77-year-old man developed multiple deep organ abscesses associated with SAB. The left anterior chest subcutaneous abscess continued into the right anterior mediastinum and had extensively destroyed the sternum. Necrotizing fasciitis was observed in the bilateral feet. The anterior mediastinum abscess was drained percutaneously, and the chest wall abscess was incised cautiously without causing an external pneumothorax. On the next day, right-sided pyothorax had developed, requiring pleural drainage. On the third day, debridement of anterior chest wall abscess followed by concurrent thoracoscopic pleural curettage and debridement of bilateral feet were performed. Thorough sternal debridement was not performed, considering the risk of respiratory failure due to the sternal defects. On the 24th day, sternum debridement and incisional drainage of sciatic rectus fossa abscess, which had been present since the time of admission, were performed to control persistent infection. The caudal half of the sternal body was resected, leaving the costal cartilage attachments. The general condition further improved without postoperative respiratory failure after the second surgery, leading to a transfer to the general ward on the 43rd day.

Conclusions
We successfully treated the severe multiple deep organ abscesses, including a mediastinum abscess with sternum destruction, by repeated removal of the infective foci while avoiding respiratory failure due to excessive debridement of the anterior chest wall, including the sternum.
Micronutrient status of individuals with overweight and obesity following 3 months’ supplementation with PolyGlycopleX (PGX®) or psyllium: a randomized controlled trial
Authors: Pal Sebely , McKay Jenny , Ho Suleen , Jane Monica , Gahler Roland J. , Wood Simon 
Published: May 2022

Abstract
Background
Safe and effective weight control strategies are needed to curtail the current obesity epidemic worldwide. Increasing dietary fibre has shown positive results with weight loss as well as in the reduction of metabolic syndrome risk factors. However, fibre can act as an inhibitor to the bioavailability of micronutrients in the gastrointestinal tract. While there is a substantial amount of scientific research into psyllium fibre, PolyGlycopleX (PGX®) is a novel fibre and as yet the effects of PGX® on micronutrient status is not well researched.

Aim
To determine whether 3-months’ supplementation with 15 g of psyllium or PGX® fibre daily affects micronutrient status of overweight and obese adults.

Methods
Overweight and obese individuals with a BMI between 25–40 kg/m2 and aged between 18 and 65 years, but otherwise healthy, were instructed to consume a 5 g sachet of psyllium, PGX® fibre or a rice flour placebo three times a day for 52 weeks as part of a larger long-term study. Blood sample data for the first 3 months were analysed for associations between serum micronutrient levels and psyllium fibre and/or PGX® supplements.

Results
No significant differences between fibre supplement groups and micronutrient status were found after 3 months at p > 0.05. Dietary intake of vitamin C was significantly lower for PGX® at 3 months compared to baseline and compared to control (p < 0.05). Folate was significantly lower in the control group after 3 months (p < 0.05). In the psyllium group, folate, sodium, zinc and magnesium intake decreased after 3 months (p < 0.05). A limitation of dietary intake data (tertiary measure) is the potential for inaccurate self-reporting, although reduced nutrient intake could be due to the satiating effect of dietary fibre.

Conclusions
There were no significant between group differences in serum micronutrient concentrations after a 3-month psyllium fibre or PGX® supplementation intervention of 15 g per day. Fibre supplementation is unlikely to compromise the nutritional status of overweight and obese individuals in the short term. Further research is recommended to monitor micronutrient status over a longer period or with a higher fibre dosage.