bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equipes de saúde frente aos cuidados a crianças em tratamento oncológico: principais intervenções
Authors: Souza Lizandra Ellem Silva de , Farias Anderson Fernandes de Carvalho , Koproski Ana Claudia , Sousa Cássio Moura de , Santos Dulcicleide Rodrigues , Oliveira Renata Silva , Lira Damião Wellington de Sousa , Silva Wesley Francisco Sousa da , Apolinário Joelma Maria dos Santos da Silva , Silva João Felipe Tinto 
Published: April 2022

O objetivo do presente estudo, é identificar os principais cuidados, e as intervenções realizadas no tratamento oncológico para crianças com o diagnóstico de câncer. Trata-se de um levantamento bibliográfico sendo então uma revisão de literatura. Realizada no período de janeiro a abril de 2022 através de uma busca nas bases de dados biblioteca Virtual em Saúde (BVS), Scientific Electronic Library Online (SciELO) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Os descritores da saúde utilizados foram: equipe de saúde AND tratamento oncológico AND pediatria. Os critérios de inclusão foram: aqueles pulicados em qualquer idioma desde que tenha tradução disponível, artigos publicados no período de 2018 a 2022 disponíveis de forma gratuita, e nas bases de dados citadas anteriormente. Diante dos achados foi possível identificar 450 artigos que após aplicar os critérios de elegibilidade e feita a leituras dos restantes totalizou 12 trabalhos utilizados. O diagnóstico de câncer é de difícil aceitação e traz consigo sentimentos de desesperança. É uma doença agressiva e que exige um tratamento específico que necessita de intervenções pelas equipes de saúde. Alguns cuidados que podem ser realizados são: cuidados paliativos, comunicação, oferta de um ambiente confortável para o paciente, e suas famílias, apoio psicológico entre outros. Conclui-se que as equipes de saúde estão diretamente ligadas ao cuidado a crianças em tratamento oncológico, pois tem o conhecimento, e capacidades técnicas para prestar esse serviço.
Correção de assimetria dentogengival através da técnica minimamente invasiva Flapless - Estudo de caso clínico
Authors: Couto Aline Vieira , Marzagão Mila , Vilela Júnior Rafael de Aguiar 
Published: April 2022

A cirurgia plástica periodontal tem sido recomendada para pacientes que apresentam insatisfação com seu sorriso ou desproporção em relação a sua anatomia gengival, dessa forma sua corretada identificação é crucial para planejar a conduta mais apropriada de tratamento e propiciar maior previsibilidade de sucesso. Sendo assim, o presente trabalho tem como objetivo demonstrar por meio de um relato de caso clínico a correção do sorriso gengival através de uma técnica minimamente invasiva denominada Flapless. Paciente, caucasiana, sexo feminino, 31 anos de idade, apresenta como queixa principal insatisfação com o tamanho e o aparecimento de seus dentes ao sorrir. Após avaliação clínica optou-se por realizar a cirurgia para aumento de coroa clínica utilizando a técnica flapless. Após 45 dias do procedimento observou-se cicatrização completa dos tecidos, e a partir do exame de profundidade de sondagem pode-se confirmar a efetividade da conquista do espaço biológico. Diante do caso supracitado observou-se que a correção da assimetria dentogengival pela técnica sem retalho (flapless) é um procedimento seguro, fácil e previsível, que possui diversos pontos positivos, dentre eles: menor sangramento e tempo cirúrgico, queda da inflamação no pós-operatório, não necessidade de sutura e mínimo desconforto durante a recuperação. Sua viabilidade e aplicabilidade clinica é notória, com chances reduzidas de recidivas e alto índice de sucesso final.
RELIGIOSITY OF THE MALAY BATUBARA TROUGH ANTHROPOLOGICAL AND HISTORICAL APPROACH
Authors: Maulana Cecep , Loebis Iin Almeina 
Published: April 2022

This research is talked about the Islamic Religious Discourse of Malay Batu Bara. In this case, the researchers took the historic sites in Batu Bara as a support in the Islamic religion of Malay Batu Bara. Background with many historic sites Batu Bara which is considered by some people to have high noble values and touched to religious part of the community and make researcher interested to explore this anthropology history approach which found the contribution about various aspects of human life, society and culture but also showed the procedure, technique and process. That is systematically arranged in disciplinary research to develop knowledge and obtain the object study. To implement this research the writer uses the methodology with a qualitative approach which results in descriptive data and the object under study is the Islamic religious of Malay Batu Bara. In collecting data researchers use the power of primary and secondary data. In analyzing the data researchers use data reduction, data presentation, and concluding that do data verification. Then in the validity of the data the researcher uses the degree of trustworthiness, dependability, and certainty. In the scientific , researchers use anthropology history. Researchers found many historic sites in Batu Bara which are very close. They are Kubah Datok Batu Bara, Sumur Istana Niat Lima Laras and Meriam Bogak. From the three historic sites, the researcher found a theoretical component from religion as said by C.Y.Glock and R. Stark that is the dimension of faith, dimension ritualistic, dimension experiential, dimension consequential, and dimension intellectual. Besides that researchers also found religious Malay Batu Bara community also influenced by beliefs in occult things such as witchcraft, rituals rejecting reinforcements, sea spells, and also related to beliefs in traditions or customs such as abstinence forbids, tapai party and balimau bathing.
Cell Inertia: Predicting Cell Distributions in Lung Vasculature to Optimize Re-endothelialization
Authors: Chan Jason K.D. , Chadwick Eric A. , Taniguchi Daisuke , Ahmadipour Mohammadali , Suzuki Takaya , Romero David , Amon Cristina , Waddell Thomas K. , Karoubi Golnaz , Bazylak Aimy 
Published: April 2022

We created a transient computational fluid dynamics model featuring a particle deposition probability function that incorporates inertia to quantify the transport and deposition of cells in mouse lung vasculature for the re-endothelialization of the acellular organ. Our novel inertial algorithm demonstrated a 73% reduction in cell seeding efficiency error compared to two established particle deposition algorithms when validated with experiments based on common clinical practices. We enhanced the uniformity of cell distributions in the lung vasculature by increasing the injection flow rate from 3.81 ml/min to 9.40 ml/min. As a result, the cell seeding efficiency increased in both the numerical and experimental results by 42 and 66%, respectively.
ECG Utilization Patterns of Patients With Arrhythmias During COVID-19 Epidemic and Post-SARS-CoV-2 Eras in Shanghai, China
Authors: Li Cheng , Chen Mu , Li Mohan , Wang Haicheng , Qiu Xiangjun , Hu Xiaoliang , Wang Qunshan , Sun Jian , Yang Mei , Zhu Yuling , Liao Peng , Zhou Baohong , Chen Min , Liu Xia , Zhao Yuelin , Shen Mingzhen , Huang Jinkang , Luo Li , Wu Hong , Li Yi-Gang 
Published: April 2022

BackgroundThe COVID-19 pandemic has led to concerns around its subsequent impact on global health.ObjectiveTo investigate the health-seeking behavior, reflected by ECG utilization patterns, of patients with non-COVID-19 diseases during and after COVID-19 epidemic.MethodsTaking advantage of the remote ECG system covering 278 medical institutions throughout Shanghai, the numbers of medical visits with ECG examinations during the lockdown (between January 23 and April 7, 2020), post-lockdown (between April 8 and December 31, 2020) and post-SARS-CoV-2 (between January 23 and April 7, 2021) periods were analyzed and compared against those during the same periods of the preceding years (2018 and 2019).ResultsCompared with the same period during pre-COVID years, the number of medical visits decreased during the lockdown (a 38% reduction), followed by a rebound post-lockdown (a 17% increase) and a fall to the baseline level in post-SARS-CoV-2 period. The number of new COVID-19 cases announced on a given day significantly correlated negatively with the numbers of medical visits during the following 7 days. Medical visit dynamics differed for various arrhythmias. Whereas medical visits for sinus bradycardia exhibited a typical decrease-rebound-fallback pattern, medical visits for atrial fibrillation did not fall during the lockdown but did exhibit a subsequent increase during the post-lockdown period. By comparison, the volume for ventricular tachycardia remained constant throughout this entire period.ConclusionThe ECG utilization patterns of patients with arrhythmias exhibited a decrease-rebound-fallback pattern following the COVID-19 lockdowns. Medical visits for diseases with more severe symptoms were less influenced by the lockdowns, showing a resilient demand for healthcare.
Relationship Between Hypertension and Basilar Atherosclerosis in Chinese Han Population: A High-Resolution Magnetic Resonance Imaging Study
Authors: Hu Feng , Lu Feng , Xiao Huiling , Dong Meixue , Xu Yan 
Published: April 2022

ObjectiveTo investigate the relationship between hypertension and basilar atherosclerosis evaluated by high-resolution magnetic resonance imaging (HR-MRI) in the Chinese Han population.MethodsHigh resolution-MRI vessel wall imaging was performed in selected 193 patients for various indications. Multivariable logistic regression models based on odds ratio (OR) with their associated 95% confidence interval (CI) were used to assess the relationship between hypertension and basilar artery (BA) plaque, moderate or severe stenosis of BA plaque, and vulnerable plaque. A linear regression model was used to assess the relationship between hypertension and BA plaque numbers.ResultsPatients with hypertension had a higher proportion of BA plaque and vulnerable plaque as well as more number of enhancements of BA plaque and serious plaque compared with normotensive patients (all values of p &lt; 0.05). Multivariable logistic regression analysis indicated that patients with hypertension had an increased risk for and more number of enhancements of BA plaque (adjusted-OR: 4.32, 95% CI 1.89–9.88, p &lt; 0.001; adjusted-β: 0.55, 95% CI 0.14–0.96, p = 0.009, respectively) and had a higher proportion of moderate or severe stenosis of BA plaque and vulnerable plaque (adjusted-OR: 3.08, 95% CI 0.77–12.32, p = 0.111; adjusted-OR: 4.52, 95% CI 1.50–13.64, p = 0.007, respectively) compared with the normotensive group. Moreover, there was a saturation effect of age on the prevalence of BA plaque and vulnerable plaque.ConclusionHypertension was the independent risk factor of BA plaque and vulnerable plaque assessed by HR-MRI in the Chinese Han population.
Evolution of the Continental Crust in the Northern Tibetan Plateau: Constraints From Geochronology and Hf Isotopes of Detrital Zircons
Authors: Liu Zeyu , Zhang Guibin , Xiong Lu , Chang Feng , Liu Shuaiqi 
Published: April 2022

To investigate the evolution of the continental crust in the northern Tibetan Plateau, detrital zircon U–Pb geochronology and Hf isotopes analysis were performed on two fluvial sand samples from North Qaidam (the Yuka and Shaliu rivers). A total of 443 detrital zircon U–Pb ages and 244 Hf isotopic results were obtained and reveal that the South Qilian, North Qaidam, and East Kunlun terranes show affinity to the western Yangtze Block. Age distributions of detrital zircons from the Yuka River cluster mainly in two age intervals of 1,000–700 and 480–400 Ma. The corresponding εHf(t) values are mostly negative, with depleted two-stage Hf model ages (TDM2) of 2.1–1.6 Ga. In contrast, age data for the Shaliu River fall in the ranges of 1,000–700, 460–380, and 260–200 Ma, with TDM2 ages of 2.0–1.6 and 1.6–1.2 Ga. In addition, zircons with Neoproterozoic ages from both river samples possess common Paleoproterozoic TDM2 ages (2.0–1.6 Ga, with a peak of 1.8–1.7 Ga), indicating that the South Qilian, North Qaidam and East Kunlun terranes were probably part of the same Neoproterozoic continent. The East Kunlun and North Qaidam terranes are inferred to include Mesoproterozoic continental crust (1.6–1.0 Ga), suggesting differences in crustal evolution between the East Kunlun–North Qaidam and Qilian terranes. Phanerozoic magmatism in these three terranes was sourced mainly from the recycling of ancient continental crust with minor contributions from the juvenile crust.
Altered Gut Microbiota in Children With Hyperuricemia
Authors: Yuan Xin , Chen Ruimin , Zhang Ying , Lin Xiangquan , Yang Xiaohong 
Published: April 2022

BackgroundIn adults, gut dysbiosis may contribute to the pathogenesis of gout. However, the characteristics of gut microbiota in children with hyperuricemia (HUA) in the absence of clinical gout have not been explored.ObjectiveThis present study analyzed the gut microbiota in children with HUA as compared to controls (Con) and explored bacterial associations that may account for differences.MethodsA total of 80 children were enrolled in this study; they were divided into HUA and Con according to the level of serum uric acid (UA). The composition of gut microbiota was investigated by 16S rRNA high-throughput sequencing.ResultsPrincipal coordinate analysis revealed that gut microbiota of the HUA group was clustered together and separated partly from the Con group. There was no difference in alpha-diversity between the two groups. However, Spearman’s correlation analysis revealed that serum UA level positively correlated with genera Actinomyces, Morganella, and Streptococcus, and negatively associated with the producers of short-chain fatty acids (SCFAs), such as Alistipes, Faecalibacterium, and Oscillospira, and the sulfidogenic bacteria Bilophila. The members of the genera Alistipes and Bilophila in the Con group were significantly more prevalent than the HUA subjects. Compared to the Con cohort, metabolic pathway predictions found that the superpathways of purine nucleotide de novo biosynthesis were decreased in HUA subjects, whereas the superpathway of purine deoxyribonucleoside de	gradation was increased.ConclusionThe composition of the gut microbiota in children with HUA differs from Con. Although causality cannot be established, modification in the microbiota that produces SCFA and sulfide may promote HUA.
Immune Checkpoint Protein Expression Defines the Prognosis of Advanced Thyroid Carcinoma
Authors: Luo Yi , Yang Yi-Chen , Shen Cen-Kai , Ma Ben , Xu Wei-Bo , Wang Qi-Feng , Zhang Yan , Liao Tian , Wei Wen-Jun , Wang Yu 
Published: April 2022

BackgroundPatients with advanced thyroid carcinoma (TC), such as anaplastic thyroid carcinoma (ATC), poorly differentiated thyroid carcinoma (PDTC), and locally advanced papillary thyroid carcinoma (PTC), have poor prognoses and require novel treatments. Immune checkpoint (ICP) inhibitors have demonstrated encouraging and good results; nevertheless, their effect in advanced TCs remains largely unclear. Thus, we demonstrated ICP profiles and investigated their potential clinical significance.MethodsA total of 234 TC patients were involved, with 22 ATCs, 44 PDTCs, and 168 PTCs, including 58 advanced PTCs. Immunohistochemistry was performed to evaluate nine ICPs [programmed cell death ligand 1 (PDL1), Programmed cell death 1 (PD1), cytotoxic T lymphocyte-associated protein 4 (CTLA4), B and T lymphocyte attenuator (BTLA), T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), lymphocyte activation gene 3 (LAG3), V-domain immunoglobulin suppressor of T-cell activation (VISTA), B7 homolog 3 (B7-H3), and T-cell immunoglobulin and mucin domain- 3 protein (TIM3)] expression via tissue microarrays (TMAs), and clinical correlations were analyzed simultaneously.ResultsATC had the highest positive rate of ICPs among the three pathological types, as well as relatively high ICP co-expression. ATC with high expression of PDL1 positivity had a poor prognosis. Shorter survival was associated with VISTA, B7H3, TIM3, and TIGIT expression in PDTC. The greater the co-expression of these four ICPs, the poorer the prognosis in PDTC patients. VISTA and B7H3 were the two most commonly expressed ICPs in advanced PTC, both of which were linked to a poor prognosis.ConclusionsPDL1 is linked to the overall survival (OS) of ATC. A subset of PDTC is likely immunogenic with poor prognosis and co-expression of VISTA, B7H3, TIM3, and TIGIT. Furthermore, VISTA and B7H3 are prognostic biomarkers in advanced PTC. Single or combined blockade targeting these ICPs might be effective for advanced TCs in the future.
Growth and Pb Uptake of Brassica campestris Enhanced by Two Ecological Earthworm Species in Relation to Soil Physicochemical Properties
Authors: Tibihenda Cevin , Zhang Menghao , Zhong Hesen , Xiao Ling , Wu Ling , Dai Jun , Liu Kexue , Zhang Chi 
Published: April 2022

A comprehensive understanding of the influence of earthworms on the growth and Pb accumulation of leafy vegetables is significant for soil management and human health. This study was aimed to evaluate the different influences of two ecological earthworm species on the growth and Pb accumulation of Brassica campestris in a Pb-contaminated soil and their relationship with soil physico-chemical properties. In a 30-day microcosm experiment, the anecic and native earthworm species Amynthas aspergillum and the epigeic species Eisenia fetida were inoculated in soil artificially contaminated with Pb at different levels (i.e., 0, 100, 500, and 1,000 mg kg−1), and B. campestris was grown. With a survival rate of 81%–100%, A. aspergillum was more tolerant to Pb contamination than E. fetida with 46%–84%. At the same time, earthworm inoculation significantly increased soil Pb bioavailability (p &lt; 0.05). At the 500 and 1,000 mg kg−1 Pb levels, the treatments with earthworm inoculation showed higher plant biomass, leaf area, and chlorophyll concentration than the treatments without earthworm. The principal component analysis (PCA) showed that earthworm inoculation exerted a stronger effect on soil properties than Pb contamination, but the latter had a stronger effect on plant growth and Pb accumulation. Compared with A. aspergillum, E. fetida had a greater effect on soil cation exchange capacity, available Pb, and plant growth and Pb accumulation. In contrast, A. aspergillum had a greater effect on soil C and N contents than E. fetida. The co-inertia analysis revealed that plant Pb accumulation was positively correlated with soil available Pb and CEC. The leaf chlorophyll concentration was closely related to soil Eh, pH, and Dissolved organic carbon. The findings of this study showed that in the Pb-contaminated soils, earthworm inoculation exerted a strong effect on soil physicochemical properties and the growth and Pb accumulation of the leafy vegetable B. campestris. Both the epigeic earthworm species E. fetida and the anecic species A. aspergillum were associated with higher Pb accumulation or concentration in B. campestris, which may bring a possible risk to food security.
Gene Expression Profiling of Glioblastoma to Recognize Potential Biomarker Candidates
Authors: Li Qiang , Aishwarya S. , Li Ji-Ping , Pan Dong-Xiao , Shi Jia-Pei 
Published: April 2022

Glioblastoma is an aggressive malignant tumor of the brain and spinal cord. Due to the blood–brain barrier, the accessibility of its treatments still remains significantly challenging. Unfortunately, the recurrence rates of glioblastoma upon surgery are very high too. Hence, understanding the molecular drivers of disease progression is valuable. In this study, we aimed to investigate the molecular drivers responsible for glioblastoma progression and identify valid biomarkers. Three microarray expression profiles GSE90604, GSE50601, and GSE134470 containing healthy and glioblastoma-affected samples revealed overlapping differentially expressed genes (DEGs). The interrelational pathway enrichment analysis elucidated the halt of cell cycle checkpoints and activation of signaling pathways and led to the identification of 6 predominant hub genes. Validation of hub genes in comparison with The Cancer Genome Atlas datasets identified the potential biomarkers of glioblastoma. The study evaluated two significantly upregulated genes, SPARC (secreted protein acidic and rich in cysteine) and VIM (vimentin) for glioblastoma. The genes CACNA1E (calcium voltage-gated channel subunit alpha1 e), SH3GL2 (SH3 domain-containing GRB2-like 2, endophilin A1), and DDN (dendrin) were identified as under-expressed genes as compared to the normal and pan-cancer tissues along with prominent putative prognostic biomarker potentials. The genes DDN and SH3GL2 were found to be upregulated in the proneural subtype, while CACNA1E in the mesenchymal subtype of glioblastoma exhibits good prognostic potential. The mutational analysis also revealed the benign, possibly, and probably damaging substitution mutations. The correlation between the DEG and survival in glioblastoma was evaluated using the Kaplan–Meier plots, and VIM had a greater life expectancy of 60.25 months. Overall, this study identified key candidate genes that might serve as predictive biomarkers for glioblastoma.
Genome-wide Exploration of a Pyroptosis-Related Long Non-Coding RNA Signature Associated With the Prognosis and Immune Response in Patients With Bladder Cancer
Authors: Gao Xin , Cai Jianping 
Published: April 2022

Background: Bladder cancer (BLCA) is a malignant tumor with a complex molecular mechanism and high recurrence rate in the urinary system. Studies have shown that pyroptosis regulates tumor cell proliferation and metastasis and affects the prognosis of cancer patients. However, the role of pyroptosis-related (PR) genes or long non-coding RNAs (lncRNAs) in BLCA development is not fully understood.Methods: We comprehensively analyzed the molecular biological characteristics of PR genes in BLCA, including copy number variation, mutations, expression and prognostic value based on TCGA database. We then identified PR lncRNAs with prognostic value based on the expression of PR genes and performed a consistent clustering analysis of 407 BLCA patients according to the expression of prognosis-related PR lncRNAs and identified two clusters. The least absolute shrinkage and selection operator (LASSO) regression was used to establish a PR lncRNA signature and calculate the risk score associated with the prognosis of patients with BLCA. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) were used to evaluate the possible functions of PR lncRNA signature. We also evaluated the relationship between the risk score and tumor immune microenvironment (TIME).Results: A total of 33 PR genes were obtained in our study and 194 prognosis-related PR lncRNAs were identified. We also constructed a signature consisting of eight-PR-lncRNAs and divided patients into high- and low-risk groups. The overall survival rate of patients with a high risk was significantly lower than patients with a low risk. The risk score was significantly correlated with the degree of infiltration of multiple immune cell subtypes and positively correlated with multiple immune checkpoint genes expression in BLCA. Enrichment analyses showed that these lncRNAs are involved in human immune regulatory functions and immune-related pathways.Conclusion: Our study comprehensively studied the molecular biological characteristics of PR genes BLCA, and the eight-PR-lncRNA signature we identified might play a crucial role in tumor immunity and may be able to predict the prognosis of BLCA patients, providing a theoretical basis for an in-depth study of the relationship between the prognosis and TIME.