bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka
Authors: Jeewandara Chandima , Jayampathi K. A. Chintha S. , Ranasinghe Thushali , Aberathna Inoka Sepali , Gunasekara Banuri , Danasekara Saubhagya , Nimasha Thashmi , Kuruppu Heshan , Dissanayake Osanda , Gamalath Nayanathara , Ekanayake Dinithi , Jayamali Jewantha , Somathilake Gayasha , Guruge Dinuka , Wijayamuni Ruwan , Kamaladasa Achala , Ogg Graham S. , Malavige Gathsaurie Neelika 
Published: July 2022

Background
There are limited data regarding the safety and immunogenicity of the Sinopharm/BBIBP-CorV vaccine in pregnancy. Therefore, we sought to investigate the antibody responses and maternal and fetal adverse events following this vaccine in pregnant mothers in Sri Lanka.

Methods and findings
SARS-CoV-2 receptor binding domain (RBD) specific total antibodies and ACE2 blocking antibodies were measured by ELISA in pregnant mothers (n = 94) who received the vaccine in the first (n = 2), second (n = 57) and third (n = 33) trimester of pregnancy. Data regarding adverse events and fetal and maternal outcomes were obtained from the women once they delivered. No adverse maternal or fetal complications reported such as miscarriage, thrombotic events, hypertensive disorders, fetal death, preterm delivery, or congenital anomalies were reported. 58/94 (61.7%) had RBD binding antibodies and were found to be seropositive at the time of recruitment. All women seroconverted after the second dose and 31/36 previously uninfected women and 57/58 previously infected women gave a positive response to ACE2 blocking antibodies. The RBD binding antibody levels (p = 0.0002) and ACE2 blocking antibodies (p<0.0001) were significantly higher in previously infected individuals post-second dose compared to uninfected individuals.

Conclusions
The Sinopharm/ BBIBP-CorV vaccine appeared safe and induced high seroconversion rates and ACE2 blocking antibodies in pregnant mothers in the second and third trimester in pregnancy. However, the RBD binding antibodies and ACE2 blocking antibodies post-second dose were significantly higher in previously infected pregnant mothers post-second dose, suggesting that two doses of the vaccine are likely to be less immunogenic in previously unexposed individuals.
Indonesian pediatricians’ knowledge of Rome IV criteria and their therapeutic approach to infantile colic
Authors: Sridevi Agus Tini , Jonathan Hubert , Wicaksono Brahmantyo Ardhi , Hegar Badriul 
Published: July 2022

Background Infantile colic is a functional gastrointestinal disorder (FGID) that occurs in approximately 20% of infants under 6 months. Even though this condition is self-limiting, inappropriate therapy affects the baby’s future quality of life. Therefore, it is essential for physicians, especially pediatricians, to employ a correct diagnosis based on the currently accepted Rome IV criteria and an appropriate therapeutic approach.
Objective To assess the gaps in Indonesian pediatricians’ understanding of infantile colic according to Rome IV criteria, their therapeutic approach in managing the condition, and associated factors.
Methods We randomly selected 131 pediatricians from the Jakarta Chapter of the Indonesian Pediatric Society to complete a questionnaire aimed at assessing their knowledge on the diagnosis of and therapeutic approach to infantile colic. The questionnaire was scored on a scale of 0 to 20. We evaluated the association between questionnaire scores and their association with several variables, including years of clinical experience, accreditation of pediatric residency institution, type of hospital, and guidelines used.
Results Out of the 131 pediatricians selected, 75 (57.3%) had used the Rome IV criteria. The mean knowledge score of those participants was 14.24 (SD 3.32) out of 20. Mean therapeutic approach score of all participants was 11.50 (SD 2.80) out of 16 points. There was no significant association between either knowledge or therapeutic approach score with length of clinical experience, accreditation of pediatric residency institution, hospital type, or guidelines used.
Conclusions Most surveyed pediatricians who have used the Rome IV criteria have fairly good knowledge of infantile colic. Overall, pediatricians also have a fairly sound therapeutic approach to infantile colic. However, with mean scores of approximately 70% of the maximum score, education is needed to improve on these areas. Knowledge of and therapeutic approach to infantile colic are not associated with length of clinical experience, accreditation of pediatric residency institution, hospital type, or guidelines used.
Using the National Indonesian Growth Chart to assess short stature and obesity in urban schoolchildren in Surakarta, Indonesia: comparisons to the WHO 2007 and CDC 2000 Growth Charts
Authors: Moelyo Annang Giri , Candrarukmi Dewinda , Rachma Ulfa Puspita 
Published: July 2022

Background The National Indonesian Growth Chart (NIGC) is a new growth chart based on Indonesian population data. To date, the CDC 2000 or WHO 2007 charts have been widely used in Indonesia to assess the growth of 5-to-18-year-old children. Use of these reference charts may lead to inaccurate conclusions about children’s nutritional status, particularly when diagnosing short stature or obesity.
Objective To compare assessments of short stature and obesity in Indonesian urban schoolchildren and adolescents based on CDC, WHO, and NIGC reference charts.
Methods Pooled anthropometric data [height, weight, and body mass index (BMI)] were collected cross-sectionally from healthy schoolchildren aged 6 to 18 years in Surakarta in 2013, 2016, 2018, and 2019. We created scatterplots for height, weight, and BMI and analyzed differences in height-for-age (HAZ) and BMI (BAZ) z-scores according to the CDC, WHO, and NIGC growth charts, then calculated differences in proportions of children identified as having short stature or obesity.
Results We included 2,582 subjects; 63% were girls. Subjects’ mean age was 13.1 (SD 3.4) years. Mean differences in HAZ between the NIGC vs. CDC chart and NIGC vs. WHO chart were 1.44 (SD 0.01) and 1.39 (SD 0.00), respectively. Mean differences in BAZ between the NIGC vs. CDC chart and NIGC vs. WHO chart were 0.18 (SD 0.01) and 0.06 (SD 0.01), respectively. The prevalence of short stature was 9.91%, 11.62%, and 0.39% according to the WHO, CDC, and NIGC charts, respectively. The prevalence of obesity was 10.15%, 5.07%, and 11.77% according to the WHO, CDC, and NIGC charts, respectively. The prevalence of obesity according to the WHO, CDC, and NIGC was 7.44%, 2.95%, and 10.08%, respectively in girls and 14.76%, 8.69%, and 14.66%, respectively in boys.
Conclusion The use of the NIGC resulted in a lower prevalence of short stature compared to the CDC or WHO charts. Compared to the WHO charts, the NIGC gave a similar prevalence of obesity overall and in boys, but a higher prevalence of obesity in girls. Compared to the CDC charts, the NIGC gave a higher prevalence of obesity both in boys and girls.
The performance of STRONGkids in the early detection of hospital malnutrition
Authors: Tommy Tommy , Dimiati Herlina , Abdullah Mars Nasrah , Yusuf Sulaiman , Thaib Teuku Muhammad , Andid Rusdi , Edward Eka Destianti 
Published: July 2022

Background Hospital malnutrition in children can increase morbidity and mortality, regardless of the type of illness. The Screening Tool for Risk on Nutritional Status and Growth (STRONGkids) is a practical and easy nutritional risk screening tool that has been widely validated in several countries.
Objective To examine the performance of STRONGkids for the early detection of hospital malnutrition in pediatric inpatients.
Methods This cross-sectional study was conducted in the pediatric ward of Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia. The pediatric inpatients' STRONGkids scores were calculated within 24 hours of admission. We used the chi-square test to compare the proportion of at-risk children based on STRONGkids scores with the prevalence of hospital malnutrition based on serial weight measurement. We also determined the sensitivity, specificity, as well as positive and negative predictive values of STRONGkids for detecting hospital malnutrition, with percentage of weight loss between admission and discharge as the gold standard.
Result Out of 75 subjects, 48% were male. The hospital malnutrition prevalence was 29.3%. STRONGkids score was significantly associated with hospital malnutrition (P=0.023). The sensitivity, specificity, positive predictive value, and negative predictive value of STRONGkids for detecting hospital malnutrition was 77.3%, 54.7%, 41.4%, and 85.2%, respectively.
Conclusion With its good sensitivity, the STRONGkids tool is effective in identifying those at risk of hospital malnutrition. In addition, with its high NPV, a “no-risk” score also effectively implies that the child is likely not to have hospital malnutrition.
The Malgrange–Galois groupoid of the Painlevé VI equation with parameters
Authors: Blázquez-Sanz David , Casale Guy , Arboleda Juan Sebastián Díaz 
Published: July 2022

Abstract
The Malgrange–Galois groupoid of Painlevé IV equations is known to be, for very general values of parameters, the pseudogroup of transformations of the phase space preserving a volume form, a time form and the equation. Here we compute the Malgrange–Galois groupoid of the Painlevé VI family including all parameters as new dependent variables. We conclude that it is the pseudogroup of transformations preserving the parameter values, the differential of the independent variable, a volume form in the dependent variables and the equation. This implies that a solution of a Painlevé VI equation depending analytically on the parameters does not satisfy any new partial differential equation (including derivatives with respect to parameters) which is not derived from Painlevé VI.
Computation of Dressians by dimensional reduction
Authors: Brandt Madeline , Speyer David E. 
Published: July 2022

Abstract
We study Dressians of matroids using the initial matroids of Dress and Wenzel. These correspond to cells in regular matroid subdivisions of matroid polytopes. An efficient algorithm for computing Dressians is presented, and its implementation is applied to a range of interesting matroids. We give counterexamples to a few plausible statements about matroid subdivisions.
Insights into the molecular basis of some chalcone analogues as potential inhibitors of Leishmania donovani: An integrated in silico and in vitro study
Authors: Osman Marwa S. , Awad Talal A. , Shantier Shaza W. , Garelnabi Elrashied A. E. , Mukhtar Moawia M. , Osman Wadah , Mothana Ramzi A. , Elhag Rashid I. 
Published: July 2022

Abstract
Protozoal infections caused by species belonging to Leishmania donovani complex are responsible for the most severe form of leishmaniasis, especially in Sudan and other developing countries. Drugs commonly used for the treatment of the disease show varying levels of effectiveness and also have associated side effects. Thus, the present work highlights the synthesis of some chalcones to be used as potential anti-leishmanial agents. The activity of the synthesized chalcones has been evaluated against L. donovani. The ADMET profile of the synthesized compounds were tested using various integrated web-based tools. Moreover, in order to investigate the molecular mechanism of action, the chalcone compounds were docked into L. donovani trypanothione reductase (TR) using Autodock 4.0 and molecular dynamics were studies. Eight compounds showed the highest activity against the morphological forms. Among these compounds, chalcones 15 has shown the highest inhibitory effect with IC50 value of 1.1 µM. In addition, pharmacokinetic and toxicological investigations revealed its good oral bioavailability and low toxicity. Furthermore, chalcone 15 was found to interact with high affinity (−13.7 kcal/mol) with TR, an essential enzyme for the leishmanial parasite. Thus, this promising activity against L. donovani supports the use of chalcone 15 as a potential new therapy for visceral leishmaniasis.
Crystal structure of (poly[µ2-(1H-pyrazol-1-yl)methyl]-1H-benzotriazole-κ
2
N:N)-(nitrato-κ
2
O:O′) silver(I), C9H8AgN7O3
Authors: Yang Jing , Wang Xin-Ling , Du Jun-Ya , Song Ning 
Published: July 2022

Abstract
C9H8AgN7O3, monoclinic, P21/c (no. 14), a = 8.3179(3) Å, b = 16.6800(5) Å, c = 9.0138(3) Å, β = 103.839(4)°, Z = 4, V = 1214.30(7) Å3, R
gt(F) = 0.0423, wR
ref(F
2) = 0.1065, T = 293(2) K.
Confirmation of Decreased Rates of Cerebral Protein SynthesisIn Vivoin a Mouse Model of Tuberous Sclerosis Complex
Authors: Saré Rachel Michelle , Torossian Anita , Loutaev Inna , Smith Carolyn Beebe 
Published: July 2022

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant disorder that results in intellectual disability and, in ∼50% of patients, autism spectrum disorder. The protein products that are altered in TSC (TSC1 and TSC2) form a complex to inhibit the mammalian target of rapamycin [mTOR; mTOR complex 1 (mTORC1)] pathway. This pathway has been shown to affect the process of mRNA translation through its action on ribosomal protein S6 and 4-elongation binding protein 1. It is thought that mutations in the TSC proteins lead to upregulation of the mTORC1 pathway and consequently an increase in protein synthesis. Unexpectedly, our previous study of a mouse model of TSC (Tsc2Djk+/−) demonstrated decreasedin vivorates of protein synthesis throughout the brain. In the present study, we confirm those results in anotherTsc2+/−mouse model, one with a different mutation locus and on a mixed background (Tsc2Mjg+/−). We also examine mTORC1 signaling and possible effects of prior isoflurane anesthesia. Because measurements of protein synthesis ratesin vivorequire surgical preparation of the animal and anesthesia, we examine mTORC1 signaling pathways both under baseline conditions and following recovery from anesthesia. Our results demonstrate regionally selective effects of prior anesthesia. Overall, our results in bothin vivomodels suggest divergences from the central hypothesis regarding TSC and show the importance of studying protein synthesisin vivo.
Preliminary Study in Overview of CYP2A6 Gene Variation in Infertile Male Patients
Authors: Mumtaz Jihadin Rasyadi , Harriyati Zeti , Adhiyanto Chris , Hiedayati Nurul , Mimanda Yona , Muniroh Muniroh 
Published: July 2022

Introduction: Infertility is a condition which is described by WHO as inability for having children after one year of relationship without birth control. this condition can be caused both from inside and outside the body. One of the major outside factors is exposure to chemical substances, which in this case nicotine substance that came from cigarettes. The CYP2A6 gene is a coding gene for the xenobiotic metabolic enzyme, in this case nicotine which can cause infertility in men. Mutations in this gene can lead to nicotine buildup, increasing nicotine effect thus increasing the risk of infertility in men. The aim of this study was to determine whether there were variations in the CYP2A6 gene in male infertile patients.Methods: The method used was the isolation of infertile and fertile sperm DNA samples (five samples each) which were then amplified at the target DNA (CYP2A6) by PCR method and then sequenced to see the nucleutide sequence.Result: The results of this study showed that there were variations in the CYP2A6 gene that occurred only in infertile patients, heterogeneous mutations in the 7788th(C-A), 8040th (C-T), 7661st (G­-C) nucleutide sequence of the CYP2A6 gene and SNP mutations in the 8250th(T>C), 8409th (T>G/C), and 8428th(C>T) nucleutide sequence of the CYP2A6 gene.Conclusion: The conclusion of this study is that there are CYP2A6 variations that found only in infertile male patients.
Memoria histórica del río Ocloro, Barrio Luján, San José, Costa Rica, 1960-2017
Authors: Chaves Villalobos María Del Carmen 
Published: July 2022

Barrio Luján es un barrio que se ubica al sur de la capital de Costa Rica, siendo parte del distrito Catedral desde 1868, en este barrio la clase trabajadora encontró un hogar, que a pesar del creciente desarrollo urbanístico de las últimas décadas, preserva características de un barrio obrero, con actividades tradicionales que han sido heredadas de generación en generación. Además, se ha caracterizado por su organización comunal en dos grandes frentes: el desarrollo comunitario y la gestión de eventos de inundación provocados por el río Ocloro. Este río ha sufrido transformaciones a lo largo de los años, no solo por la carga de contaminación de residuos sólidos y líquidos que recibe actualmente, sino también, por las obras de entubado que ha experimentado en algunos segmentos del cauce, para intentar controlar las inundaciones.
Este documento pretende describir el proceso dinámico que ha experimentado Barrio Luján, para facilitar la comprensión de la situación actual del río Ocloro y su impacto sobre el ambiente y la comunidad.
De colegios y conventos de la Península Ibérica al virreinato del Perú. Una aproximación de los franciscanos embarcados durante los años 1577 a 1620
Authors: Rivasplata varillas Paula Ermila 
Published: July 2022

El continuo envío de franciscanos a las Indias españolas entre 1577 a 1620 era una prueba de su necesidad para la consolidación del Imperio, sobre todo en los lugares donde no había tanta presencia de autoridades laicas. Los comisarios fueron, al menos entre los franciscanos, los encargados de traer a Indias misioneros de los distintos conventos y casas de formación de la Metrópoli en la Península Ibérica. El número de franciscanos que llegaron a Indias prácticamente duplicó a los dominicos, sus más cercanos antagonistas. En este contexto se realizara una aproximación de los 40 grupos de franciscanos que vinieron al virreinato del Perú de los 133 grupos, enviados a América y Asia entre 1577 a 1620. Algunos religiosos de estos grupos se convirtieron en obispos, cronistas e incluso santos.
Effect of Yoga on the Stress, Anxiety, and Depression of COVID-19-Positive Patients: A Quasi-Randomized Controlled Study
Authors: Sharma Nitesh , Sahni Pooja Swami , Sharma Uma Shankar , Kumar Jyoti , Garg Rahul 
Published: July 2022

Abstract
The spread of COVID-19 has resulted in reports of increase in stress, anxiety, and depression across society, especially in people who have tested positive for COVID-19, which affects their mental health and well-being. This article reports a quasi-randomized controlled study conducted in the COVID wards of a hospital to examine the efficacy of add-on yoga intervention in reducing stress, anxiety, and depression in COVID-affected patients under quarantine. The peripheral capillary oxygen saturation level and heart rate of the COVID-19-affected patients were also measured. A total of 62 COVID-19-positive patients participated in the study. The participants were randomized into a control group (n = 31), which received conventional medical treatment alone, and a yoga intervention group (n = 31), which received 50 minutes of yoga intervention along with the conventional medical treatment. Standardized Hospital Anxiety and Depression Scale, Generalized Anxiety Disorder–7 Item, Patient Health Questionnaire–9, and Perceived Stress Scale were administered at the beginning and end of the quarantine period. A significant decrease in stress, anxiety, and depression was observed in the patients who undertook the add-on yoga intervention. There was also a significant decrease in anxiety in the control group, but the intervention group had a larger decrease compared to the control group. Further significant improvements in oxygen saturation and heart rate levels were observed in the group of patients who were practicing yoga, but no significant improvement was observed in the control group. Findings of this study suggest that yoga intervention can be an effective add-on practice in reducing stress, anxiety, and depression levels of COVID-19 patients.
Basal cell carcinoma excision with bilobed flap nasal reconstruction
Authors: Kumar Kuldeep , Prinja Sumit , Bansal Garima , R Asuvini , Dhanoa Simran , Rani Diksha 
Published: July 2022

: Basal cell carcinoma (BCC) is a slow growing, locally destructive, malignant tumor of the skin. It is derived from non- keratinizing cells that originate from the basal layer of the epidermis. After excision nasolabial flap, median forehead dorsal nasal flap, glabellar flaps, bilobed flaps, cheek and craniofacial flaps are used for nasal reconstruction. The Zitelli’s bilobed flap is one of the most useful flaps for nasal reconstruction. It is a simple double transposition flap and is designed to move more skin, without deformation. A 60-years old male patient reported to our department with complains of circular raised and reddish discoloration lesion on the left side of the nose. Surgical excision and reconstruction of defect using bilobed flap was planned under general anaesthesia. The flap was designed in such a manner that the flap could be turned over the defect on the ala of the nose and closure of the donor site could be done primarily without deformity. Surgical excision of the nose lesion was done and reconstruction was performed using bilobed flap. The patient has been followed up for 1year with no evidence of recurrence. The bilobed flap is a versatile and reliable flap for coverage of small skin and soft tissue defects of the lower third of the nose. It gives a successful outcome if it is designed well and performed properly. In this case it helped us to achieve a defect free cosmetically fine nose after excision of basal cell carcinoma nose.
THE CORRELATION BETWEEN MOTIVATION AND STUDENTS’ SPEAKING SKILLS AT INTERNATIONAL CLASS PROGRAM (ICP) OF IAIN SALATIGA
Authors: Rozi Irfan 
Published: July 2022

This study is to find a correlation between motivation and students’ speaking skills in the English Education Department at the International Class Program of IAIN Salatiga. The methodology of the research was quantitative research, especially correlation studies. The techniques of collecting data are questionnaires to find out students’ motivation and documentation techniques to find out the speaking skills of the students.
The writer finds 1) The students’ motivation of the English Education Department at International Class Program (ICP) IAIN Salatiga. It shows that there are 5 students or about 17.2% have high motivation level, 20 students or 69.0% have a medium motivation level, and 4 students or 13.8% have a low motivation level. It shows that the subject as an educated group has stable motivation. 2) The student’s speaking skills of the English Education Department at International Class Program (ICP) IAIN Salatiga. It shows that all students in this research have a GPA of more than 3.50. They are 4 students who have a 3.75 speaking score and 25 students have a 4.00 speaking score, so all students have a “Cumlaude” predicate. It shows that the students have high speaking skills in English. 3) There is no significant correlation between motivation and students’ speaking skills in the English Education Department at the International Class Program (ICP) of IAIN Salatiga. It is proved by the Sig value that shows 0.284 > 0.05 and t count 0.206> t table 0.00/0.20 where t count is no correlation.
Keywords: Correlation, Psychological factors, Students’, Motivation, speaking skills.