bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of a cost-effectiveness threshold for cancer interventions in Iran
Authors: Safari Hossein , Poder Thomas G. , Afshari Somayeh , Nahvijou Azin , Arab-Zozani Morteza , Moradi Nasrin , Ameri Hosein 
Published: December 2022

Background and objectivesThe estimation of a cost- Effectiveness (CE) threshold from the perspective of those who have experienced a life-threatening disease can provide empirical evidence for health policy makers to make the best allocation decisions on limited resources. The aim of the current study was to empirically determine the CE threshold for cancer interventions from the perspective of cancer patients in Iran.MethodsA composite time trade-off (cTTO) task for deriving quality adjusted life-year (QALY) and a double-bounded dichotomous choice (DBDC) approach followed by open-ended question for examining patients’ willingness-to-pay were performed. A nationally representative sample of 580 cancer patients was recruited from the largest governmental cancer centers in Iran between June 2021 and January 2022, and data were gathered using face-to-face interviews. The CE threshold was calculated using the nonparametric Turnbull model and parametric interval-censored Weibull regression model. Furthermore, the factors that affect the CE threshold were determined using the parametric model.ResultsThe estimated CE threshold using the nonparametric Turnbull model and parametric interval-censored Weibull regression model was IRR 440,410,000 (USD 10,485.95) and IRR 595,280,000 (USD 14,173.33) per QALY, respectively. Gender, age, education, income, type of cancer, and current treatment status were significantly associated with the estimated CE threshold.ConclusionsThe value of parametric model-based threshold in this study was 1.98 times the Iranian GDP per capita, which was lower than the CE threshold value recommended by the WHO (i.e., 3 times the GDP per capita) for low-and middle-income countries.
Respiratory support strategies in the prevention of bronchopulmonary dysplasia: A single center quality improvement initiative
Authors: White Heather , Merritt Kamaris , Martin Kirsti , Lauer Emily , Rhein Lawrence 
Published: December 2022

Background and objectivesBronchopulmonary dysplasia (BPD) continues to be a significant morbidity affecting very preterm infants, despite multiple advancements in therapies to treat respiratory distress syndrome and prevent BPD. Local quality improvement (QI) efforts have shown promise in reducing unit or system-wide rates of BPD. In preterm infants born between 23- and 32-weeks' gestation, our aim was to decrease the rate of BPD at 36 weeks corrected gestational age from 43% to 28% by January 2019.MethodsDirected by a multidisciplinary respiratory QI team, we gradually implemented the following interventions to reach our aim: (1) early initiation of non-invasive ventilation in the delivery room, (2) initiation of caffeine prior to 24 h of life, (3) administration of early selective surfactant per a well-defined guideline, (4) continuation of non-invasive ventilation until 32 and 0/7 weeks corrected gestational age (CGA), and (5) a revision of the early selective surfactant guideline. Outcome measures included rates of BPD, and process measures included compliance with the above interventions.ResultsA total of 509 infants with an average gestational age of 29 1/7 weeks and birth weight of 1,254 (SD±401) grams were included. The rate of BPD in our unit decreased from a baseline of 43% to 19% from the start of the project in October 2016 until the first quarter of 2022 (p &lt; 0.00001). The greatest reductions in BPD rates were seen after the initiation of the guideline to extend non-invasive ventilation until 32 0/7 weeks CGA. The rate of severe BPD decreased from 22% to 9%.ConclusionsIn preterm infants born between 23- and 32-weeks' gestation, our local QI interventions to reduce rates of BPD were associated with a reduction in rates by 56%. Increased use of antenatal steroids and higher birth weights post- vs. pre-intervention may have contributed to this successes.
Sugarcane stem node detection and localization for cutting using deep learning
Authors: Wang Weiwei , Li Cheng , Wang Kui , Tang Lingling , Ndiluau Pedro Final , Cao Yuhe 
Published: December 2022

IntroductionIn order to promote sugarcane pre-cut seed good seed and good method planting technology, we combine the development of sugarcane pre-cut seed intelligent 0p99oposeed cutting machine to realize the accurate and fast identification and cutting of sugarcane stem nodes.MethodsIn this paper, we proposed an algorithm to improve YOLOv4-Tiny for sugarcane stem node recognition. Based on the original YOLOv4-Tiny network, the three maximum pooling layers of the original YOLOv4-tiny network were replaced with SPP (Spatial Pyramid Pooling) modules, which fuse the local and global features of the images and enhance the accurate localization ability of the network. And a 1×1 convolution module was added to each feature layer to reduce the parameters of the network and improve the prediction speed of the network.ResultsOn the sugarcane dataset, compared with the Faster-RCNN algorithm and YOLOv4 algorithm, the improved algorithm yielded an mean accuracy precision (MAP) of 99.11%, a detection accuracy of 97.07%, and a transmission frame per second (fps) of 30, which can quickly and accurately detect and identify sugarcane stem nodes.DiscussionIn this paper, the improved algorithm is deployed in the sugarcane stem node fast identification and dynamic cutting system to achieve accurate and fast sugarcane stem node identification and cutting in real time. It improves the seed cutting quality and cutting efficiency and reduces the labor intensity.
Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome
Authors: Zhu Qianqian , Cai Jing , Guo Haiyan , Zhao Yan , Lin Jiaying 
Published: December 2022

BackgroundRecently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS).MethodsThis is a retrospective cohort study included a total of 1,652 women with PCOS and 12,543 women without PCOS conducted from 1 January 2015 to 31 December 2019. The average daily concentration data of six air pollutants (PM2.5, PM10, O3, NO2, SO2, and CO) during different exposure windows were obtained. Generalized estimating equation models were used to evaluate the association of air pollution with pregnancy outcomes.ResultsAir pollutants were not found to have a significant association with pregnancy rates among patients with PCOS. However, each IQR increase in PM10 exposure during period 3 (embryo transfer to serum HCG test) was associated with the reduced clinical pregnancy rate (adjusted OR = 0.92, 95% CI: 0.84–0.99) for patients without PCOS. Patients without PCOS showed lower clinical pregnancy rates with increased exposure to NO2 during periods 2 (oocyte retrieval to embryo transfer) and 5 (start of gonadotropin medication to embryo transfer), with aORs and 95% CIs of 0.94 (0.88, 0.99) and 0.94 (0.88, 0.98), respectively. Each IQR increase in SO2 among patients without PCOS during periods 1 (start of gonadotropin medication to oocyte retrieval), 2, 5, and 6 (start of gonadotropin medication to serum HCG test) was related to a decrease in clinical pregnancy rate. For the live birth rate, no significant relationship was found between air pollutants, including PM2.5, PM10, SO2, NO2, CO, and O3, and the live birth rate for women with PCOS. However, women without PCOS presented a lower probability of live birth with exposure to SO2 during periods 1, 2, 5, and 6.ConclusionThis retrospective study of reproductive-aged women observed no significant relationships between ambient pollutants and pregnancy outcomes among women with PCOS but found negative associations among women without PCOS.
Utility of Metagenomic Next-Generation Sequencing in Infective Endocarditis: A Systematic Review
Authors: Haddad Sara F. , DeSimone Daniel C. , Chesdachai Supavit , Gerberi Danielle J. , Baddour Larry M. 
Published: December 2022

Blood cultures have been the gold standard for identifying pathogens in infective endocarditis (IE). Blood culture-negative endocarditis (BCNE), however, occurs in 40% or more of IE cases with the bulk of them due to recent antibiotic exposure prior to obtaining blood cultures. Increasingly, molecular techniques are being used for pathogen identification in cases of BCNE and more recently has included metagenomic next-generation sequencing (mNGS). We therefore performed a literature search on August 31, 2022, that assessed the mNGS in IE and 13 publications were identified and included in a systematic review. Eight (61.5%) of them focused only on IE with mNGS performed on cardiac valve tissue in four studies, plasma in three studies and cardiac implantable electronic devices (CIED) in one study. Gram-positive cocci, including Staphylococcus aureus (n = 31, 8.9%), coagulase-negative staphylococci (n = 61, 17.6%), streptococci (n = 130, 37.5%), and Enterococcus faecalis (n = 23, 6.6%) were the predominant organisms identified by mNGS. Subsequent investigations are needed to further define the utility of mNGS in BCNE and its impact on patient outcomes. Despite some pitfalls, mNGS seems to be of value in pathogen identification in IE cases, particularly in those with BCNE. This study was registered and on the Open Science Framework platform.
Dynamic Removal of Nickel (II) on Elaeis guineensis Waste Bed: Study of the Breakage Curve and Simulation
Authors: Tejada-Tovar Candelaria , Villabona-Ortíz Angel , González-Delgado Ángel Darío 
Published: December 2022

This research focused on the use of residual fiber from oil palm (Elaeis guineensis) for Ni (II) adsorption in a packed bed column. An analysis was conducted on the effect and statistical incidence of changes in temperature, adsorbent particle size, and bed height on the adsorption process. The results showed that particle size and bed height significantly affect the adsorption of Ni (II) ions, reaching adsorption efficiencies between 87.24 and 99.86%. A maximum adsorption capacity of 13.48 mg/g was obtained in the bed with a break time of 180 min. The Ni (II) adsorption in the dynamic system was evaluated by the analysis of the breakage curve with different theoretical models: Yoon–Nelson, dose–response, and Adams–Bohart; the dose–response model was the most appropriate to describe the behavior of the packed bed with an R2 of 84.56%. The breakthrough curve obtained from Aspen Adsorption® appropriately describes the experimental data with an R2 of 0.999. These results indicate that the evaluated bioadsorbent can be recommended for the elimination of Ni (II) in aqueous solutions in a dynamic system, and the simulation of the process can be a tool for the scalability of the process.
Comparative Analysis of Facial Coloration between Introduced and Source Populations of the Red Wood Ant Formica paralugubris
Authors: Frizzi Filippo , Buonafede Laura , Masoni Alberto , Balzani Paride , Santini Giacomo 
Published: December 2022

The variation in the typical black-reddish color of red wood ants (Formica rufa group) has been recently suggested as a good indicator of habitat quality, being dependent on environmental conditions. However, the relative contribution of external factors and heritability in shaping this trait is poorly investigated. In this study, we compared the facial coloration of workers from four introduced populations of Formica paralugubris with those of the two Alpine populations from which they had been taken. We used a Relative Warp Analysis to describe the variations in the shape of this trait. We expected each introduced population to be more similar to its population of origin if the color pattern was predominantly genetically determined. On the contrary, due to the considerable differences in habitat type and climate between the Alps and the Apennines, we expected to observe differences between the introduced population and their origin population if the coloration was mostly environmentally determined. With one exception that we discuss, the results showed that ants from the two source populations had different phenotypes, and that the introduced populations had a shape similar to the population of origin, suggesting a stable genetic background. Surprisingly, the habitat type seems to have a less clear effect, even if within-population differences suggest the influence of very localized environmental factors. Finally, we found that the facial coloration shape is affected by the ant’s size, a result in line with previous studies.
Serological and Molecular Survey of Leishmania infantum in a Population of Iberian Lynxes (Lynx pardinus)
Authors: Lima Clara M. , Santarém Nuno , Neves Nuno Costa , Sarmento Pedro , Carrapato Carlos , de Sousa Rita , Cardoso Luís , Cordeiro-da-Silva Anabela 
Published: December 2022

Leishmania infantum, the sand fly-transmitted protozoan parasite responsible for leishmaniasis in humans, dogs, and cats, is endemic in the Iberian Peninsula. However, the impact of L. infantum infection on the conservation of the endangered Iberian lynx (Lynx pardinus) is unknown. Herein, we describe for the first time the occurrence of L. infantum infection among a population of reintroduced and wild-born L. pardinus living in the Portuguese Guadiana Valley Park. The presence of infection was addressed by molecular detection of Leishmania kinetoplast DNA (kDNA) in 35 lynxes, with further confirmation of L. infantum species performed by an internally transcribed spacer (ITS)-1 sequencing. Eight blood samples were positive for kDNA, and ITS-1 sequencing confirmed the presence of L. infantum in two of those samples. Exposure to Leishmania was screened in a group of 36 lynxes using an immunofluorescence antibody test (IFAT) and a multi-antigen enzyme-linked immunosorbent assay (ELISA), using SPLA, rK39, and CPX as Leishmania-specific antigens. Four animals presented a positive IFAT at a dilution of 1:40. Eight samples were considered seropositive to all ELISA Leishmania-specific antigens. Agreement between PCR, IFAT, and all ELISA antigens was found for 1 in 27 samples. These results highlight the susceptibility of autochthonous L. pardinus to L. infantum infection. Further investigation is required to assess the impact of L. infantum infection on this wild species conservation.
THE INTERNALLY MIGRANT STUDENTS’ ADAPTATION TO THE ENVIRONMENT OF UNIVERSITY BY MEANS OF TRAINING ACTIVITIES
Authors: BELYAEVA N. , BOLOVATSKA Y. 
Published: December 2022

The article deals with the problem of the internally migrant students’ adaptation to the environment of university by means of training activities. The various aspects of support for internally displaced youth have been analyzes in the article. The most effective forms, methods and means of educational activity in higher educational institutions are considered. The authors underlines in the article that the Students involved in educational activities feel comfortable in the new student community and realizing themselves in their own projects and programs.Involvement of internally displaced persons in the arsenal of various forms of educational activities helps to overcome the obstacles encountered by settlers. In the course of the research and the questionnaire survey, we identified two key groups of such difficulties, in particular: the educational and organizational difficulties that arise when organizing the educational process in higher education and organizing the life of a student outside the university; psychological difficulties that manifest themselves in increasing the rate of emotional excitement, anxiety, neuroticism; reducing communicability, emotional stability, self-control, etc.An effective means of adapting internally displaced persons to the university's educational environment is educational activity that allows the settler to feel fit in the new student community, make a personal contribution to solving social problems and overcome the difficulties associated with forced migration processes in Ukraine.
EDUCATION OF PERSONALITY OF FUTURE TEACHER BY MEANS OF OLYMPISM
Authors: MOMOT O. 
Published: December 2022

In the article education of personality of future teacher is described by means of olympism as vital philosophy, that glorifies and unites in harmonious unit the internalss of body, will and mind. Combining sport with a culture and education, olympism aims to create such way of life, that would be based on the gladnesses obtained through effort, educational values of kind example and respect of universal ethic principles.The plan of work of the Poltava regional branch of the Olympic academy of Ukraine is shown. A separation is the guide- book of distribution of olympic, healthy ideas. One of directions of activity of that there is education of personality of future teacher by facilities of olympism, health and creation of healthy environment of high school. It would give an opportunity to deepen knowledge of personality of future teacher about Olympic ideas, Olympic movement, Olympic games of remoteness and contemporaneity, about importance of development of spiritual and physically developed personality. Such approach would give an opportunity to warn such dangerous negative phenomena, as smoking, alcoholism, drug addiction and to inoculate to the future specialists love to the environment and health. Except it to interest young people in athletic-sporting activity that is a substantial push in creation of healthy environment of high school.
Life Values in the Proverbs used in Vilavangodu Region
Authors: S. L Helen Japa Rose 
Published: December 2022

Proverbs is one of the literary forms. Like folk songs, folk tales, fairy tales etc., proverbs belong to the genre of oral literature. A proverb is a language that originates from primitive knowledge. Describing an object in one or two lines without directly describing it is called riddles. In Tamil it is called pisi or nodi. These riddles help in developing intellectual activities. Mothers use riddles to develop their child's intellectual power. Proverbs have appeared in all the languages and it is intertwined with people's lives. Proverbs have been used by the Tamil people since the ancient time itself. Proverbs is the shortest form of oral language-based folk idioms. It has a great impact on people. Even today riddles are most commonly used by all humans. Our forefathers have used to say proverbs to indicate certain actions in the rural areas, to make comments and create awareness. It is infused with experience and knowledge. It can be said that it is the experience of a society's long-term circulation. In particular, proverbs describe something succinctly, clearly and beautifully. This article is in a position to establish how these proverbs are learned and used by the people Vilavankodu region.
Peranan Faktor Sosial Ekonomi Dan Partisipasi Wanita Tani Dalam Kegiatan Kelompok Wanita Tani (KWT) Terhadap Keberhasilan Program Kawasan Rumah Pangan Lestari (KRPL) (Suatu Kasus pada Kelompok Wanita Tani (KWT) di Kecamatan Cianjur Kabupaten Cianjur)
Authors: Permana Rosdianti , Sukmawati Dety , Dasipah Euis 
Published: December 2022

Tujuan penelitian ini adalah untuk mengetahui: (1) seberapa besar pengaruh faktor sosial ekonomi terhadap keberhasilan program KRPL; (2) seberapa besar pengaruh partisipasi anggota kelompok wanita tani terhadap keberhasilan program KRPL; (3) seberapa besar pengaruh faktor sosial ekonomi dan partisipasi anggota kelompok wanita tani terhadap keberhasilan program KRPL. Penelitian ini menggunakan metode survei dengan unit analisisnya adalah petani anggota kelompok wanita tani yang melaksanakan program Kawasan Rumah Pangan Lestari di Kecamatan Cianjur Kabupaten Cianjur. Teknik pengambilan sampel dilakukan secara sampling sebanyak 79 responden. Â Data yang terkumpul dianalisis dengan menggunakan analisis jalur (path analysis), analitik disesuaikan dengan hasil pengujian hipotesis. Hasil penelitian menunjukkan bahwa Faktor Sosial Ekonomi dan Partisipasi Anggota Kelompok Wanita Tani secara simultan berpengaruh signifikan terhadap Keberhasilan program KRPL sebesar 90,3 %. Sisanya sebesar 9,7 % dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini.
THE STRUGGLE OF THE SOVIET POWER WITH THE VOLYN INSURGENT ARMY
Authors: Makarchuk I. 
Published: December 2022

The purpose of the article is to analyze the formation of underground cells of the anti-Bolshevik insurgent movement in Volyn after the Second Winter Campaign of the UNR army. Coverage of the measures of the Soviet authorities, aimed at the detection, intelligence development and destruction of an underground organization of an insurgent character called the Volyn Insurgent Army, which operated on the territory of the Volyn Province during 1922.
Methodology. When writing the article, the basic principles of historical knowledge were used: historicism, scientificity, objectivity. Specific search tasks of the research were solved by problem-chronological means (optimal involvement of the thematic literature and source base); historical-comparative (analysis of various sources and formation of relevant research provisions and conclusions); critical analysis (critical attitude to various sources) methods.
The scientific novelty consists in a comprehensive study of the stages of detection and liquidation by Soviet law enforcement agencies of the Volyn rebel army on the basis of unpublished sources and the available historiographical base. New source material, in particular archival documents, important for solving the problem, was introduced into scientific circulation and analyzed.
Conclusions. The unsuccessful completion of the Second Winter Campaign of the UNR army accelerated the decline of the anti-Bolshevik insurgent movement, which continued under the repressive policy of the Soviet government. Even in such difficult conditions for the local insurgents, several underground cells began to operate on the territory of Volyn, which later merged into a whole insurgent organization called the Volyn Insurgent Army. The insurgents' activation and lack of conspiracy experience on their part allowed the Soviet authorities to discover that not just ordinary partisan units, but a whole underground organization with its own structure and tasks, began to operate in Volyn. In order to eliminate all the cells and structures of the VPA as effectively as possible, the Bolsheviks decided to infiltrate the rebels with their agents under the guise of members of the anti-Soviet underground. They successfully managed to do this and the work to identify all the participants of the underground continued. The success of the insurgents in expanding their network and their preparation for the uprising forced representatives of the Soviet authorities to quickly draw up a plan to eliminate the VPA. The very liquidation of the organization was quite successful for the Bolsheviks, because most of the members of the VPA were arrested or destroyed, although the underground command staff managed to retreat abroad.