bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TDS model and epistemic justice for bilingual learners
Authors: Marupi Omphile , Charamba Erasmos 
Published: September 2022

The object of research: Contemporary research suggests the use of an instructional language different from students’ home language as a major contributing factor to academic underachievement. This has also been the case in Gwanda South, Zimbabwe, where Sesotho speaking secondary school learners are taught through English only and have been underperforming. Analysts have suggested the use of a language different from their learners’ home language as the major cause of academic underachievement.
Investigated problem: This study explores how concurrent use of multiple languages can enhance learning in a bilingual community. Results from national examinations show learners from Gwanda South perform comparatively lower than most districts in the country, resulting in calls for transformative pedagogy. This mixed methods study used a descriptive survey design that opted for face-to-face interviews and questionnaires to collect data from 120 secondary school learners, 20 parents, 20 teachers, 10 head teachers and 10 Teachers-in-Charge. Convenience sampling was used to identify participants.
The main scientific results: Results from the study indicate participants’ willingness for pedagogies that acknowledge multiple languages. They also indicate an enhanced academic performance among students when the TDS model is used for pedagogical purposes. As a result, the article introduces a model that is being proposed and recommended for use in bilingual settings, called The Dual System (TDS) Model. The TDS Model has a number of variables that make it operate effectively and efficiently. Its basis is two languages in an environment and community with a keen interest in the successful use of those languages in the classroom. Both teacher and learner ought to be tuned to dual language use and to accept full roles for both languages in the classroom. Translanguaging then is a key element that defines academic activities. Bilingual education where Sesotho and English are key classroom languages is recommended for Gwanda South, Matabeleland South, Zimbabwe.
The area of practical use of the research results: The TDS Model has a number of variables that make it operate effectively and efficiently. Its basis is two languages in an environment and community with a keen interest in the successful use of those languages in the classroom. Both teacher and learner ought to be tuned to dual language use and to accept full roles for both languages in the classroom. Translanguaging then is a key element that defines academic activities. Bilingual education where Sesotho and English are key classroom languages is recommended for Gwanda South, Matabeleland South, Zimbabwe
Suggestopedia: an effective way to teach and learn a foreign language
Authors: Darici Nurullah 
Published: September 2022

The most prominent feature distinguishing humans from animals is their ability to communicate in many ways. People recognize and introduce themselves through language. The individual thinks, speaks, and writes in the language of the society in which s/he lives. When an individual enters a different community, the need to learn a foreign language arises because s/he would have to speak the language of that society to communicate. Language learners and teachers should benefit more from the suggestopedia method. This study is a review article that presents brief theoretical, qualitative information on the suggestopedia method in language learning. This method helps learners improve their feelings, distract them from language learning fears, and reduce learning barriers to getting rid of the fear of making mistakes. Learners of a foreign language will discover their learning potential and keep their information in mind for the longest time by this method.
The object of research: Although there are many ways or methods of learning and teaching a foreign language, suggestopedia technique is still a popular way for teachers and learners in teaching and learning a foreign language. Therefore, it is high time to introduce suggestopedia method to the interested readers. The object of this study is to revise the related literature of Suggestopedia and compile significant features in one study.
Investigated problem: Motivation is a paramount factor for any kind of activity. Learners usually get exhausted in learning a new challenging thing and they might get demotivated due to the environment they are in. One of the most effective barriers in front of learning a foreign language is not having self-esteem which decreases motivation and ends up with failure. However, some people may have the misconception that their academic skills are not sufficient to proceed. Their main problem may be solved through what this methos suggests.
The main scientific results: There may be various reasons why one cannot learn a language effectively. Suggestopedia offers a solution to one dimension of the problem by highlighting important points of psychological aspect. This may help many learners to more efficiently learn a foreign language
The area of practical use of the research results: The results this review extracted can be used by those who feel psychological barriers in front of learning a foreign language
Estimating rainfall–runoff modeling using the rainfall prognostic model-based artificial framework with a well-ordered selective genetic algorithm
Authors: Kumar Shailesh , Pandey K. K. , Kumar Sunil , Supriya Sunidhi 
Published: September 2022

Abstract
Rainfall–runoff modeling is one of the most well-known applications of hydrology. The goal of rainfall–runoff modeling is to simulate the peak river flow caused by an actual or hypothetical rainfall force. In existing methods, the rainfall–runoff relationships are quantified to predict the daily streamflow of each catchment from its landscape attributes to measure the daily rainfall. However, the structural model error, infiltration rate, and the steep slopes of the hill affect the prediction process. To tackle these issues, this paper proposed a novel rainfall prognostic model-based artificial framework, which predicts day-to-day rainfall to prevent environmental disasters. The day-to-day predictions minimize the risks to life and property and also manage the agricultural farms in a better way because the possibility of rainfall has been estimated earlier. Furthermore, the posterior fire-breathing network is utilized to estimate model errors in the computational runoff by using time-dependent and random noise to the model's internal storage to solve the uncertainty problem. Since the model errors are estimated, there are limits to the infiltration rate and thus a prophetic multilayer network is utilized which relies on the soil runoff levels. Moreover, the network measures the dynamics of soil moisture to regulate the infiltration rate according to the rural or urban section. Moreover, to measure the surface water from the steep slopes, the system offered a well-ordered selective genetic algorithm to calculate the velocity of runoff in different bend areas to overcome the numerical problem. Thus, the model results showed that the work effectively predicts the rainfall from the investigation of model errors, infiltration rates, and velocity to achieve a better prediction range in the rainfall.
Formation and influencing factors of disinfection by-products from bacterial materials in drinking water distribution systems
Authors: Li Jing , Feng Cuimin , Li Ying , Yang Weiqi , Zhang Zibin 
Published: September 2022

Abstract
In recent years, the contribution of bacterial materials in water distribution systems to DBPs has attracted widespread attention from researchers. The risks and influencing factors of bacterial DBPs are reviewed. Factors affecting the generation of bacterial DBPs include the characteristics of bacterial materials, disinfection process, piping materials, and water quality. Among the major components of biofilms, proteins or amino acids have the greatest risk of DBPs. Among the commonly used disinfection methods, chlorine is more suitable for continuous disinfection of pipe networks than chloramine, but chlorine dioxide may be a better substitute in the future. Pipes with good biological stability, such as polyethylene (PE) pipe, should be encouraged to be used in water supply networks. Periodic removal of biofilms, reduction of organic matter and bromide ion concentrations, and maintenance of high flow rates are effective means to reduce bacterial DBPs. The control, removal and monitoring devices of tube wall biofilm need to be further developed and promoted. In the future, it is urgent to develop new disinfectants that are not easy to react with biomolecules and natural organic matter, and produce fewer or no by-products.
Study on the migration performance of Cs(I) in the treatment of simulated radioactive wastewater by electrodialysis
Authors: Xie Yudong , Wang Xiaowei , Men Jinfeng , Qin Feibo 
Published: September 2022

AbstractAs a competitive radioactive wastewater treatment technology, electrodialysis (ED) has the advantages of low operating pressure and high cycles of concentration. In order to analyze the migration performance of radionuclides during the treatment of radioactive wastewater by ED, a radionuclide migration model was constructed based on the mass conservation law and Faraday's law with the typical radionuclide cesium as the research object. Experiments were carried out for the treatment of simulated radioactive wastewater in a small-scale ED system, and the average migration rate of radionuclides under different operating conditions was predicted by the model. The results showed that the experimental values of concentration and average migration rate of Cs(I) were significantly correlated with the calculated values of the model, in which the relative error of the average migration rate was 4.54%. The variation characteristics of Cs(I) concentration in diluted solution under different current and volume ratio conditions can be predicted by the model. The average variation rate of Cs(I) concentration decreases significantly with the increase of current and volume ratio.
Novel Formulation Approaches used for the Management of Osteoarthritis: A Recent Review
Authors: Kumar Mohit , Dogra Raghav , Mandal Uttam Kumar 
Published: September 2022

Background:The osteoarthritis (OA) causes economic, social, and health difficulties to the patients. Approximately 10% to 15% of all persons above the age of 60 have some degree of OA. OA is more common in women than in males. Diagnosed OA prevalence varies widely among EU member states, from 2.8% in Romania to 18.3% in Hungary.Introduction:Osteoarthritis (OA) is a slow-progressing, non-inflammatory disorder. This disorder ultimately destroys articular cartilage and other joint components. The main symptoms are stiffness, pain, loss of flexibility, swelling, and bone spurs. Many risk factors, both modifiable and non-modifiable, have been associated with osteoarthritis (OA), including obesity and lack of exercise, genetic susceptibility, bone density, work-related damage, and trauma.Method:Hydrogels, micro and nano-sized particles, and novel topical gels are among the most common examples. Hydrogels are cross-linked polymers with 3-D architecture that can hold water and expand like living tissue. The Micro-carriers, and nano-based drug delivery systems provide several advantages and may demonstrate prolonged release, controlled release, and higher joint half-life.Result:OA-induced male Lewis rats were injected with celecoxib-loaded PEA microspheres to assess in vivo biocompatibility and degradation. According to the findings of this research, PEA microspheres loaded with celecoxib may be employed as safe delivery of drug with self-regulating behavior for the pain treatment related to knee osteoarthritis.Conclusion:The concept of novel drug delivery systems has shown tangible benefits as a new avenue for precise, safe, and high-quality drug delivery for OA treatment. Currently, herbal drugs are also used in osteoarthritis treatment due to their potency and fewer side effects in contrast to synthetic drugs. The herbo-synthetic approach is a new concept for the delivery of both herbal and synthetic drugs together to exploit their individual beneficial effects while reducing undesirable side effects.
Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps,
Tools and Traps
Authors: Ramos André , Granzotto Natalli , Kremer Rafael , Boeder Ariela Maína , de Araújo Julia Fernandez Puñal , Pereira Aline Guimarães , Izídio Geison Souza 
Published: September 2022

Abstract:
Scientists have systematically investigated the hereditary bases of behaviors since the 19th
century, moved by either evolutionary questions or clinically-motivated purposes. The pioneer studies
on the genetic selection of laboratory animals had already indicated, one hundred years ago, the immense
complexity of analyzing behaviors that were influenced by a large number of small-effect genes
and an incalculable amount of environmental factors. Merging Mendelian, quantitative and molecular
approaches in the 1990s made it possible to map specific rodent behaviors to known chromosome regions.
From that point on, Quantitative Trait Locus (QTL) analyses coupled with behavioral and molecular
techniques, which involved in vivo isolation of relevant blocks of genes, opened new avenues
for gene mapping and characterization. This review examines the QTL strategy applied to the behavioral
study of emotionality, with a focus on the laboratory rat. We discuss the challenges, advances and
limitations of the search for Quantitative Trait Genes (QTG) playing a role in regulating emotionality.
For the past 25 years, we have marched the long journey from emotionality-related behaviors to genes.
In this context, our experiences are used to illustrate why and how one should move forward in the
molecular understanding of complex psychiatric illnesses. The promise of exploring genetic links between
immunological and emotional responses are also discussed. New strategies based on humans,
rodents and other animals (such as zebrafish) are also acknowledged, as they are likely to allow substantial
progress to be made in the near future.
Efficient Synthesis of the Key Intermediate of Scopolamine by [4+3]
Cycloaddition Reaction
Authors: Li Gudong , Zheng Guojun , Duan Xiuyuan , Wang Qian , Shahab Muhammad , Liang Chaoqun 
Published: September 2022

Abstract:
Scopolamine, as an anticholinergic agent, plays a regulatory role in the peripheral nervous
system. In this paper, 6,7-dehydrotropinone, which is the key intermediate of scopolamine, is synthesized
in moderate yield through [4+3] cyclization reaction and Barton deoxygenation reaction. This
route has good application prospects with mild reaction conditions, moderate yield, and simple operating
procedures.
Efficient Synthesis of 4-Arylmethylene-3-methylisoxazol-5(4H)-one Derivatives Catalyzed by Malic Acid
Authors: Kiyani Hamzeh , Tahmasabi Sayed Zakaria , Samimi Heshmat Allah 
Published: September 2022

Abstract:The efficient, straightforward, and green procedure was established in the direction of synthesis of 4-arylmethylene-3-methylisoxazol-5(4H)-one derivatives using the malic acid, which acted as the catalyst for the three-component heterocyclization reaction. In this reaction, aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/ethyl benzoylacetate were applied as the reactants. The reaction was optimized to attain the best conditions for the synthesis of target heterocyclic compounds in a single step route. The best results were obtained from optimization experiments using 10 mol% malic acid as the catalyst, water solvent, and 50ºC temperature. The noticeable features of this process are the simplicity of the experimental procedure, the easy separation of the pure compounds from the product mixture, the simplicity of operation, avoidance of any hazardous organic solvents, no use of chromatographic purification techniques, clean reaction profiles, high yields, relatively short reaction time, and eco-friendliness
Clinical Approaches to Minimize Readmissions of Patients with COPD: A
Narrative Review
Authors: Duong-Quy Sy , Vo-Pham-Minh Thu , Duong-Thi-Thanh Van , Craig Timothy , Nguyen-Nhu Vinh 
Published: September 2022

Abstract:
Chronic obstructive pulmonary disease (COPD) is a progressive disease and also a lead-ing cause of morbidity and mortality worldwide. The frequent readmissions of patients with COPD may reduce lung function, mental health, and quality of life; it also increases the cost of treatment and mortality rate. Some common factors that may increase the readmission frequency of COPD pa-tients include delay of diagnosis, advanced lung function decline, lack of adherence for COPD treatment, ineffective management of comorbidities, acute exacerbation or stable COPD, and infec-tions. However, these factors might be well controlled with appropriate approaches to minimize the readmission of patients with COPD. In this review, we propose a strategy with a seven-step ap-proach to reduce the readmission in COPD patients, including early diagnosis of COPD, optimal treatment for stable COPD, targeted management of comorbidities, adequate therapy for acute ex-acerbations, individualized action plans for COPD patients, effective prevention of bacterial and vi-ral infections, and adaptive program of pulmonary rehabilitation. Thus, implementing this approach may reduce the risk of readmission in patients with COPD.
GC-MS Screening of Adiantum lunulatum Burm. F Phytochemicals and Interaction with COX-2, TRPV1, and TRPC3 Proteins-bioinformatics Approach
Authors: Nair Raveendran Harikumaran , Jerom Jenat Pazheparambil , Sajan Ann Liya , Manirajan Binoy Ambika , Mohammed Sudheer 
Published: September 2022

Background:The Adiantum lunulatum is a medicinally important pteridophyte used to treat inflammatory-related diseases. The phytochemical profile of this plant is poorly investigated.Objective:Here, we screened the nonpolar phytochemicals and their interactions with cyclooxygenase 2 (COX-2) enzyme (inflammation), transient receptor potential cation channel V member 1 (TRPV1), and transient receptor potential channel 3 (TRPC3) receptors (pain).Methods:The identification and molecular docking analysis used gas chromatography-mass spectrometry (GC-MS), AutoDock Vina, and BIOVIA discovery studio visualizer 2020. The online computer tools Swiss ADME and admetSAR predicted these compounds' bioavailability and toxicity.Results:GC-MS analysis detected the 12 different compounds. Five compounds with high similarity to mass spectrum were selected for molecular docking. This includes 2, 4 di-tert-butylphenol; n-hexadecanoic acid (palmitic acid); 2 pentadecanone, 6, 10, 14-trimethyl-; Quinoline 1, 2 dihydro 2, 2, 4 trimethyl and 3, 7, 11, 15-tetramethyl hexadec 2-en-1-yl acetate. These compounds showed interaction with the binding pocket of COX-2, TRPV1, and TRPC3 proteins. This interaction with enzyme and receptor activity causes a reduction in inflammatory pathogenesis.Conclusion:This study enhances our fundamental knowledge of biologically important volatile phytochemicals in Adiantum lunulatum dichloromethane extract and its possible effects in reducing inflammatory responses.
Structure Analysis of Unsaturated Polymyxin E Components Based on
High-Performance Liquid Chromatography - Quadrupole/ Time of Flight
Tandem Mass Spectrometry and Photochemical Reaction
Authors: Zhang Hanzhi , Zhao Jingdan , Tian Zhenhua , Liu Hao 
Published: September 2022

Background:
Polymyxin E (PME), which is a complex of cationic cyclic lipodecapeptides, is used to treat multidrug-resistant gram-negative bacterial infections. Besides the main components PME1 and PME2, polymyxin containing unsaturated fatty acyl (FA) group with lower contents is hardly to determine the structure without chromatographic preparations and NMR.

Introduction:
The peptide sequences of PME components has been carried out based on high performance liquid chromatography-quadrupole / time-of-flight mass spectrometry (HPLC-Q/TOF-MS). However, the components with double bond on the FA, such as 2’, 3’-dehydro PME1, were difficult to be determined or easily misjudged by MS/MS. The transformation of such unsaturated components to be epoxidized components or di-hydroxylated components can promote the acquisition of more fragment ions in the MS/MS, so as to assist in judging the position of double bonds on FA.

Methods:
In this paper, the PME mixtures were dissolved in an equal proportion of 20% ACN aqueous solution and 2-acetylpyridine. The above PME solution was transferred to a quartz cuvette and irradiated with the ultraviolet lamp at 254 nm for 8h. The dehydro PME components were converted to be epoxy PMEs and dihydroxy PMEs. A fragmentation pathway of epoxidized components or di-hydroxylated components based on Q/TOF-MS/MS was proposed for the first time.

Results:
According to the characteristic ions of epoxidized components and di-hydroxylated components, 2’, 3’-epoxy PME1/E2 and 2’, 3’-dihydroxy PME1/E2 were confirmed. It can be inferred that the double bond is located at the 2’, 3’-position of FA.

Conclusion:
The structure of unsaturated PME component with double bond on the FA is elucidated by HPLC-Q/TOF-MS combined with photochemical reaction. This strategy is applicable to other lipopeptides containing unsaturated FA chain.
Mechanism of Shizi Sanhua Decoction on Male Oligospermia Revealed by
Herbs-Ingredients and Disease Co-Target Genes Sub-Network
Authors: Li Haibin , Cao Hongwen , Wang Dan , Feng Yigeng , Chen Lei , Gao Renjie 
Published: September 2022

Background:
Shizi Sanhua Decoction, a traditional Chinese medicine (TCM) prescription,
shows a treatment advantage on male oligospermia. While due to the complexity of the compatibility
(multiple herbs composition), the underlying mechanism remains to be deciphered.

Methods:
Herbs-ingredients-target genes were retrieved from the Traditional Chinese Medicine Systems
Pharmacology Database and Analysis Platform (TCMSP) and SWISSADME database, intersecting
with oligospermia-related derived from DisGeNET to obtain co-target genes. The protein-protein
interaction (PPI) network of co-target genes was constructed based on the STRING database, and highly
condensed sub-networks and top 10 Hub genes were identified with the CytoHubba plug-in. Herbs, ingredients
and KEGG enrichment information were projected onto the identified highly condensed subnetwork
to build Herbs-ingredients and disease co-target genes sub-network.

Results:
After integration of herbs-ingredients-target genes (n=453) with disease genes (n=329), 29 cotarget
genes were obtained. Among them, PARP1, AR, CYP17A1, ESR1, ABCB1, STS, CFTR,
SOAT1, NR5A1, and HIF1A were related to male infertility (WP4673-WikiPathways). Sub-network
analysis further revealed the top 10 Hub genes, and the relation with the herbs and ingredients was
demonstrated in the sub-network of herbs-ingredients and disease co-target genes. As expected, reproductive-
related biological processes (mammary gland epithelium development, GO:0061180; Oocyte
meiosis, hsa04114; Progesterone-mediated oocyte maturation, hsa04914) were enriched. Thyroid hormone
signaling pathway (hsa04919), Serotonergic synapse (hsa04726), Chemical carcinogenesisreactive
oxygen species (hsa05208), and Endocrine resistance (hsa01522) may contribute to the development
of male oligospermia.

Conclusion:
Constructed herbs-ingredients and disease co-target genes sub-network discloses specific
bioprocesses and molecular targets of Shizi Sanhua Decoction in oligospermia treatment.