bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase Inhibitors
Authors: Metelo Ana M. , Jozwik Agnieszka , Luong Le Anh , Dominey-Foy Delaney , Graham Charlotte , Attwood Charlotte , Inam Shafqat , Dunlop Alan , Sanchez Katy , Cuthill Kirsty , Rice Carmel , Streetly Matthew , Bentley Trevor , Boldajipour Bijan , Sommer Cesar , Sasu Barbra , Benjamin Reuben 
Published: March 2022

Multiple myeloma remains an incurable plasma cell malignancy despite the rapidly evolving treatment landscape. Chimeric antigen receptor T cells targeted against BCMA have recently shown great promise in relapsed refractory multiple myeloma; however, all patients ultimately still progress from their disease. Lack of CAR T-cell persistence, impaired T-cell fitness in autologous CAR T-cell products and the presence of an immunosuppressive bone marrow (BM) microenvironment are contributory factors to treatment failure. We generated anti-BCMA CAR T cells from healthy donors (HD) and patients with multiple myeloma at different stages of disease to compare their T-cell profile, fitness, and cytotoxic activity in preclinical studies. We also used an ex vivo assay with multiple myeloma BM biopsies from distinct genomic subgroups to test the efficacy of HD-derived CAR T cells in a clinically relevant model. HD volunteers showed increased T-cell counts, higher CD4/CD8 ratio, and expanded naïve T-cell population compared with patients with multiple myeloma. After anti-BCMA CAR T-cell production, patients with relapsed multiple myeloma had lower frequencies of CAR+ T cells, decreased central memory phenotype, and increased checkpoint inhibitory markers compared with HD-derived products, which compromised their expansion and cytotoxicity against multiple myeloma cells in vitro. Importantly, HD-derived CAR T cells efficiently killed primary multiple myeloma cells within the BM microenvironment of different multiple myeloma genomic subgroups and their cytotoxic activity could be boosted with gamma secretase inhibitors. In conclusion, allogeneic anti-BCMA CAR T cells are a potential therapeutic strategy for patients with relapsed multiple myeloma and should be further developed in the clinic.Significance:Multiple myeloma is an incurable cancer of the plasma cells. A new therapy with anti-BCMA CAR T cells — the patient's own T cells genetically engineered to find and kill myeloma cancer cells — has shown encouraging results. Unfortunately, patients still relapse. In this study, we propose to use T cells from HD volunteers, which have a stronger T-cell fitness, higher cancer killing capacity, and are ready to be administered when needed.
Short-Term Postoperative Use of Rivaroxaban to Prevent Radial Artery Occlusion After Transradial Coronary Procedure: The RESTORE Randomized Trial
Authors: Liang Dongjie , Lin Qingcheng , Zhu Qianli , Zhou Xiaodong , Fang Ying , Wang Liangguo , Xiang Guangze , Zheng Kenneth I. , Huang Weijian , Shan Peiren 
Published: March 2022

Background:
Adequate procedural anticoagulation is crucial for radial artery occlusion (RAO) prevention in patients undergoing transradial access coronary catheterization, although the effect of postprocedural anticoagulation lack thorough investigation. The aim of this study was to evaluate the clinical value of short-term postoperative anticoagulation with rivaroxaban for 24 hours and 1-month RAO prevention in patients who received transradial coronary procedures.

Methods:
A total of 382 patients were randomized to receive either placebo (control group) or rivaroxaban 10 mg once daily for a period of 7 days (rivaroxaban group) to evaluate the effect of the rivaroxaban in the prevention of 24 hours and 1-month RAO assessed by Doppler ultrasound.

Results:

There was no significant difference in the incidence of 24-hour RAO (8.9% versus 11.5%;
P
=0.398) between the rivaroxaban group and control group (odds ratio, 0.75 [95% CI, 0.39–1.46];
P
=0.399). In contrast, the 1-month RAO (3.8% versus 11.5%;
P
=0.011) was significantly reduced in patients who received rivaroxaban as compared with those who did placebo (odds ratio, 0.22 [95% CI, 0.08–0.65];
P
=0.006). For patients with 24-hour RAO, the rivaroxaban group was associated with higher recanalization rate of the radial artery (69.2% versus 30.0%;
P
=0.027) compared with the control group. No significant differences can be observed between the 2 groups for access-site complications or bleeding events.

Conclusions:
Short-term postoperative anticoagulation with rivaroxaban did not reduce the rate of 24-hour RAO but improved 1-month RAO, because of higher recanalization of the radial artery. However, larger clinical trials are needed to prove our results.

Registration:

URL:
https://www.chictr.org.cn
; Unique identifier: ChiCTR1900026974.
Designing an Automatic Agent for Repeated Language–based Persuasion Games
Authors: Raifer Maya , Rotman Guy , Apel Reut , Tennenholtz Moshe , Reichart Roi 
Published: March 2022

AbstractPersuasion games are fundamental in economics and AI research and serve as the basis for important applications. However, work on this setup assumes communication with stylized messages that do not consist of rich human language. In this paper we consider a repeated sender (expert) – receiver (decision maker) game, where the sender is fully informed about the state of the world and aims to persuade the receiver to accept a deal by sending one of several possible natural language reviews. We design an automatic expert that plays this repeated game, aiming to achieve the maximal payoff. Our expert is implemented within the Monte Carlo Tree Search (MCTS) algorithm, with deep learning models that exploit behavioral and linguistic signals in order to predict the next action of the decision maker, and the future payoff of the expert given the state of the game and a candidate review. We demonstrate the superiority of our expert over strong baselines and its adaptability to different decision makers and potential proposed deals.1
Richard Simon and the tiers parti
Authors: Mithen Nicholas 
Published: March 2022

Abstract
Recent scholarship has sought to reinterpret the French biblical scholar Richard Simon, viewing him less as the unwitting participant in an agenda of radical secularisation, and more as the culmination of centuries of humanistic learning. This article repositions this rehabilitated Simon within the contested theological landscape of late seventeenth century French Catholicism. Drawing upon Simon’s exchanges with the Jansenist Antoine Arnauld and the Jesuit Dominique Bouhours concerning the translation of the New Testament into French, it argues that Simon’s critical approach to scripture can be seen as—and Simon himself defined it as—representative of a tiers parti. This tiers parti stood outside of the structural divisions within seventeenth century Catholicism between Jansenists and Molinists, between advocates of efficacious and sufficient grace. It deployed historical criticism to bolster the authority of Tradition, to undermine rational and speculative theology, and to mollify intra-confessional division.
Antilogy, Dialectic and Dialectic’s Objects in Plato’s Phaedrus
Authors: Lavilla de Lera Jonathan 
Published: March 2022

Abstract
Plato’s Phaedrus is a dialogue in which rhetoric is not only discussed, but also displayed. The first half of the plot depicts a rhetorical contest in which Socrates himself offers two opposite speeches on love, a kind of dissoi logoi. The current paper tries to explain that the second half of the dialogue offers the necessary keys to understand that for Plato true rhetoric is nothing but dialectic and that beyond the apparent antilogic exercise carried out by Socrates there can be found philosopher’s dialectical practice itself. Last but not least, the article defends that dialectic does not necessarily deal with Forms.
Ἀθρόα ἐπιβολή: Galen as a Source for Plotinus, 3.7(45).1
Authors: Chiaradonna Riccardo 
Published: March 2022

Abstract
Plotinus’ outline of his method on inquiry on eternity and time in 3.7(45).1.4 includes a reference to ‘concentrated apprehensions of thought’ ([…] ταῖς τῆς ἐννοίας ἀθροωτέραις ἐπιβολαῖς […]). Scholars sometimes argue that Plotinus is here referring to the Epicurean notion of ἀθρόα ἐπιβολή (Epic., Ep. Hdt. 35.9; PHerc. 346, col. 4.24–28). I suggest instead that Gal., mm x.38 Kühn provides the closest parallel to Plotinus’ passage. Further parallels between 3.7 and Galens’ lost On Demonstration suggest that Galen, not Epicurus, is Plotinus’ immediate source.
Proclus’ Theory of Seemingly “Useless” Theorems
Authors: Kiosoglou Sokratis-Athanasios 
Published: March 2022

Abstract
Do all theorems contribute equally in the context of a more geometrico exposition? In this paper it is suggested that Proclus’ account of seemingly useless theorems, as found in his In Euclidem, points to a negative answer to this question. In the first part, I reconstruct Proclus’ theory of seemingly useless theorems. Although not purely constructive, the latter facilitate the refutation of objections, limit argumentative diversity and promote interdisciplinarity (i.e., connections between different sciences). The second part discusses these functions in relation to three concrete examples in the Elements of Physics, thus indicating that this theory crucially informed Proclus’ own practice in his two Elementationes. Finally, I conclude with certain broader remarks about the literary genre of Elementatio.
A Jet-Centered Framework for Investigating High Plains Winter Storm Severity
Authors: Winters Andrew C. , Walker Curtis L. 
Published: March 2022

Abstract
This study utilizes a winter severity index (WSI) to characterize the impacts of High (Great) Plains winter storms during the 2006/07–2018/19 winter seasons across Nebraska and the Colorado Front Range. Winter storms are specifically defined based on the severity of their meteorological impacts and are required to influence a majority of Department of Transportation (DOT) districts within both states. Following their identification, winter storms are examined using a jet-centered framework based on the two leading modes of North Pacific jet (NPJ) and North Atlantic jet (NAJ) variability. The analysis reveals that a retracted or equatorward-shifted NPJ establishes a highly amplified flow pattern conducive to cyclogenesis over the central United States, while a poleward- or equatorward-shifted NAJ favors the development of a strongly baroclinic environment across the study region that serves as a focal region for cyclogenesis and precipitation. Composite analyses of winter storms that rank in the top 25% and bottom 25% in terms of their aggregate WSI are also performed to identify characteristics of the synoptic-scale evolution that discriminate between “high impact” and “low impact” events, respectively. High-impact events are found to feature a more amplified upper-tropospheric flow pattern over the eastern North Pacific and western United States relative to low-impact events, which subsequently favors stronger cyclogenesis over the southern plains. The integration of jet regimes with winter storm severity metrics as part of this study offers the potential to enhance impact-based decision support services and provide the weather enterprise, and its stakeholders, with critical life-saving information.
Oceanic Advection Controls Mesoscale Mixed Layer Heat Budget and Air–Sea Heat Exchange in the Southern Ocean
Authors: Gao Yu , Kamenkovich Igor , Perlin Natalie , Kirtman Benjamin 
Published: March 2022

Abstract
We analyze the role of mesoscale heat advection in a mixed layer (ML) heat budget, using a regional high-resolution coupled model with realistic atmospheric forcing and an idealized ocean component. The model represents two regions in the Southern Ocean, one with strong ocean currents and the other with weak ocean currents. We conclude that heat advection by oceanic currents creates mesoscale anomalies in sea surface temperature (SST), while the atmospheric turbulent heat fluxes dampen these SST anomalies. This relationship depends on the spatial scale, the strength of the currents, and the mixed layer depth (MLD). At the oceanic mesoscale, there is a positive correlation between the advection and SST anomalies, especially when the currents are strong overall. For large-scale zonal anomalies, the ML-integrated advection determines the heating/cooling of the ML, while the SST anomalies tend to be larger in size than the advection and the spatial correlation between these two fields is weak. The effects of atmospheric forcing on the ocean are modulated by the MLD variability. The significance of Ekman advection and diabatic heating is secondary to geostrophic advection except in summer when the MLD is shallow. This study links heat advection, SST anomalies, and air–sea heat fluxes at ocean mesoscales, and emphasizes the overall dominance of intrinsic oceanic variability in mesoscale air–sea heat exchange in the Southern Ocean.
Development and external validation of a nomogram for predicting renal function based on preoperative data from in-hospital patients with simple renal cysts
Authors: Chen Yiding , Chen Lei , Meng Jialin , Zhang Meng , Xu Yuchen , Fan Song , Liang Chaozhao , Liao Guiyi 
Published: March 2022

Objective To develop and validate a nomogram for predicting renal dysfunction in patients with simple renal cysts (SRCs). Methods We performed a multivariable logistic regression analysis of an in-hospital retrospective cohort of patients with SRCs in the Urology Department of the First Affiliated Hospital of Anhui Medical University. For prognostic model development, 386 patients with SRCs were enrolled from January 2016 to December 2018. External validation was performed in 46 patients with SRCs from January 2019 to April 2019. The primary outcome was renal dysfunction. Results Patients were divided into normal or abnormal estimated glomerular filtration rate groups (293 vs. 93) based on the cut-off value of 90 mL/minute/1.73 m2. Logistical regression analysis determined that age, haemoglobin, globulin, and creatinine might be associated with renal dysfunction, and a novel nomogram was established. Calibration curves showed that the true prediction rate was 77.42%, and decision curve analysis revealed that the nomogram was more effective with threshold probabilities ranging from 0.1 to 0.8. The area under the curves were 0.829, 0.752, and 0.888 in the overall training, internal, and external validation cohorts, respectively. Conclusions We established a nomogram to predict the probability of developing renal dysfunction in patients with SRCs.
Dancing in the Paradox: Virtual Human Resource Development, Online Teaching, and Learning
Authors: Bennett Elisabeth E. , McWhorter Rochell R. 
Published: March 2022

Problem The world is undergoing digital transformation accelerated by the COVID-19 pandemic, resulting in several paradoxes, such as isolation versus increased accessibility, and structure versus flexibility. With many joining Virtual Human Resource Development (VHRD), the relationship of online teaching and learning to VHRD is understudied, thus necessitating exploration. Solution The complexity of virtual environments, dual emphasis on formal and informal learning, and the socio-cultural nature of large digital networks and learning management systems are explored. This article describes selected connections, presents recommended practices and implications for online instruction from the VHRD perspective, discusses digital tools for instructors and trainers, and presents cautions. Stakeholders Learning professionals are encouraged to dance within the paradox to promote learning agility for adapting within digital transformation and to use both high tech and low tech designs to shape resilient learners who combine hard and soft skills valuable for organizations that are increasing the use of artificial intelligence applications.
Investigation into the ophthalmic artery and its branches by superselective angiography
Authors: Akdemir Aktaş Hilal , Mine Ergun Kadriye , Tatar İlkan , Arat Anıl , Mutlu Hayran Kadir 
Published: March 2022

Background The vascular anatomy of orbit is highly complex, and the main blood supply to the orbit is via the ophthalmic artery, which is a branch of the internal carotid artery. The purpose of this study was to determine the morphometry of the ophthalmic artery and its branches by superselective angiography in a large series of pediatric patients. Methods We evaluated 134 angiographies performed on children with intraocular retinoblastoma undergoing intra-arterial chemotherapy. The origin, diameter, and angiographic visibility percentages of the ophthalmic artery and its branches were examined according to age group and sex. Results The ophthalmic artery originated 97.8% from the internal carotid artery and 2.2% from the middle meningeal artery. The mean diameter of ophthalmic artery was measured 0.76 ± 0.14 mm in girls, 0.80 ± 0.15 mm in boys and 0.79 ± 0.15 mm in general. The posterior ciliary, lacrimal, inferior muscular, and anterior ethmoidal arteries had a higher angiographic visibility percentages (> 85%) than the other OA branches. Only the diameter of the dorsal nasal artery showed a significant correlation with age. The supratrochlear and posterior ciliary arteries showed statistically significant relationship with sex. Conclusions Present study will make a substantial contribution to the pediatric literature about the ophthalmic artery and its branches. A better understanding of ophthalmic artery morphology can help surgeons and neurointerventional radiologists to avoid possible severe complications during embolization, intra-arterial chemotherapy, cosmetic procedures, endonasal and orbital surgeries.
Contrast enhanced duplex ultrasound for early postoperative follow-up after endovascular aneurysm repair: Relation to patient’s initial risk of complications
Authors: Park Young Jun , Mok Sang Kyun , Kim Jang Yong , Park Sun Cheol , Yun Sang Seob 
Published: March 2022

Objectives Current guidelines recommend initial postoperative follow-up with computed tomography angiography (CTA) after endovascular aneurysm repair (EVAR). However, CTA has risks associated with ionizing radiations and nephrotoxic contrast agents. We investigated possibilities to replace the initial postoperative CTA with contrast enhanced duplex ultrasound (CE-DUS) in selected patients. Methods Out of the 273 consecutive patients who underwent EVAR, 173 were excluded and the 100 patients who underwent CTA and CE-DUS imaging concurrently (≤1 month interval between CTA and CE-DUS imaging) within 60 days after EVAR were analyzed. Patients who underwent EVAR outside the manufacturer’s instructions for use or who had endoleaks discovered on intraoperative angiography were classified as the high-risk group, otherwise, they were classified as the low-risk group. Measurements of diagnostic values of CE-DUS ​​related to the detection of complications were calculated using CTA as the gold standard. McNemar’s test was performed to compare these values and Pearson correlation coefficient was derived to compare CE-DUS measurements of sac diameters with CTA. Results In the low-risk group, no difference was observed between CE-DUS and CTA in the detection of EVAR-related complications (sensitivity = 0.95, specificity = 0.93). In the high-risk group, CE-DUS was not as accurate as CTA for the detection of overall EVAR-related complications (sensitivity = 0.57, specificity = 0.86, p = 0.04) and for the detection of complications other than endoleaks ( p = 0.02). Regarding sac diameter measurement, there was good agreement between CE-DUS and CTA ( r = 0.92, p < 0.001). Conclusions First postoperative CE-DUS was reliable for the evaluation of EVAR-related complications compared to CTA in selected patients. Individualized EVAR follow-up strategy using CE-DUS based on the initial risk of EVAR-related complications should be considered.
High-flow nasal cannula versus noninvasive ventilation in patients with COVID-19: a systematic review and meta-analysis
Authors: He Yuewen , Liu Na , Zhuang Xuhui , Wang Xia , Ma Wuhua 
Published: March 2022

Background: During the novel coronavirus disease 2019 (COVID-19) pandemic raging around the world, the effectiveness of respiratory support treatment has dominated people’s field of vision. This study aimed to compare the effectiveness and value of high-flow nasal cannula (HFNC) with noninvasive ventilation (NIV) for COVID-19 patients. Methods: A comprehensive systematic review via PubMed, Web of Science, Cochrane, Scopus, WHO database, China Biology Medicine Disc (SINOMED), and China National Knowledge Infrastructure (CNKI) databases was conducted, followed by meta-analysis. RevMan 5.4 was used to analyze the results and risk of bias. The primary outcome is the number of deaths at day 28. The secondary outcomes are the occurrence of invasive mechanical ventilation (IMV), the number of deaths (no time-limited), length of intensive care unit (ICU) and hospital stay, ventilator-free days, and oxygenation index [partial pressure of arterial oxygen (PaO2)/fraction of inhaled oxygen (FiO2)] at 24 h. Results: In total, nine studies [one randomized controlled trial (RCT), seven retrospective studies, and one prospective study] totaling 1582 patients were enrolled in the meta-analysis. The results showed that the incidence of IMV, number of deaths (no time-limited), and length of ICU stay were not statistically significant in the HFNC group compared with the NIV group ( ps = 0.71, 0.31, and 0.33, respectively). Whereas the HFNC group performed significant advantages in terms of the number of deaths at day 28, length of hospital stay and oxygenation index ( p < 0.05). Only in the ventilator-free days did NIV show advantages over the HFNC group ( p < 0.0001). Conclusion: For COVID-19 patients, the use of HFNC therapy is associated with the reduction of the number of deaths at day 28 and length of hospital stay, and can significantly improve oxygenation index (PaO2/FiO2) at 24 h. However, there was no favorable between the HFNC and NIV groups in the occurrence of IMV. NIV group was superior only in terms of ventilator-free days.