bluuebunny/crossref_metadata_2025_split huggingface dataset:
ArTisaN trial protocol: a single Centre, open-label, phase II trial of the safety and efficacy of TheraSphere selective internal radiation therapy (SIRT) in the treatment of inoperable metastatic (liver) neuroendocrine neoplasia (NENs)
Authors: Sharma Rohini , Slater Susanna , Evans Joanne , Martinez Maria , Ward Caroline , Izadi Hooshang , Wernig Florian , Thomas Rob 
Published: July 2022

Abstract
Background
Neuroendocrine neoplasias (NENs) are a rare type of malignancy that arise from the cells of the neuroendocrine system. Most patients present with advanced, unresectable disease, typically with metastases to the liver. The presence of liver metastases dictates prognosis and there has been a number of studies investigating therapies that reduce the burden of liver disease. Selective Internal Radiation Therapy (SIRT) allows the delivery of targeted high dose radiation directly to tumours, with relative sparing of the surrounding liver tissue. Here, we describe the design and rationale of ArtTisaN, a phase II study to assess efficacy and tolerability of SIRT using TheraSpheres for the management of liver metastases secondary to NENs.

Methods
Twenty-four eligible participants will be recruited to receive SIRT with TheraSpheres. The primary objective is to determine the objective response rate to treatment, defined as the rate of best overall response in the treated liver volume. In addition, total hepatic response and overall response will be assessed according to RECIST 1.1. The second co-primary objective is to determine the incidence of adverse and serious adverse device events. The secondary objectives are progression free survival, overall survival and quality of life. Additional exploratory objectives include investigation of circulating biomarkers of response and identification of a radiomic signature of response.

Discussion
This trial will provide prospective evidence on the efficacy of SIRT using TheraSpheres for the management of liver metastases.

Trial registration
NCT04362436.
Screening of BRCA1/2 variants in Mauritanian breast cancer patients
Authors: Brahim Selma Mohamed , Zein Ekht Elbenina , Bonnet Crystel , Hamed Cheikh Tijani , Salame Malak , Zein Mohamed Vall , Khyatti Meriem , Tolba Ahmedou , Houmeida Ahmed 
Published: July 2022

Abstract
Background and study aim
Carrying a pathogenic BRCA1/2 variant increases greatly young women’s risk of developing breast cancer (BC). This study aimed to provide the first genetic data on BC in Mauritania.

Methods
Using NGS based screening; we searched for BRCA1/2 variants in DNA samples from 137 patients diagnosed for hereditary BC.

Results
We identified 16 pathogenic or likely pathogenic (PV) variants carried by 38 patients. Two predominant BRCA1 PV variants were found: c.815_824dup and c.4986 + 6 T > C in 13 and 7 patients, respectively. Interestingly, three novels BRCA1/2 predicted pathogenic variants have also been detected. Notably, no specific distribution of BRCA1/2 variants was observed regarding triple negative breast cancer (TNBC) or patient gender status.

Conclusions
In this first genetic profiling of BC in Mauritania, we identified a substantial number of BRCA1/2 pathogenic variants. This finding could be important in the future diagnosis and prevention policy of hereditary BC in Mauritania.
Reliability levels of motor competence in youth athletes
Authors: Silva Ana Filipa , Nobari Hadi , Badicu Georgian , Ceylan Halil Ibrahim , Lima Ricardo , Lagoa Maria João , Luz Carlos , Clemente Filipe Manuel 
Published: July 2022

AbstractThis study aimed to analyze the reliability of the tests included in the motor competence assessment (MCA) battery and compare the effects of the number of trials per test. Thirty female volleyball players (14.6 ± 1.3 years of age) were tested. The participants performed two or three trials of each test. Intra-class correlation (ICC) was calculated, and a paired sample t-test analyzed the variations between trials (1st vs. 2nd vs. 3rd). Results revealed a significant difference between the first and the second trials for jumping sideways [t(29) = -4.108, p < 0.01], standing long jump [t(29) = -3.643, p < 0.01], and shuttle run [t(29) = -3.139, p < 0.01]. No significant result was registered in the shifting platforms, ball throwing and kicking between the first and second trials. Hence, any difference was recorded between the second and third trial. High ICC values were registered in lateral jumps, among the three repetitions of ball kicking and ball throwing, and between the last two repetitions of shuttle run. Almost perfect values were recorded for the shifting platforms and standing long jump. Nevertheless, there seems to be a learning effect between the first and the second repetition—no differences were registered only considering the two manipulative tests. In conclusion, except for jumping sideways, the MCA tests are reliable and only need to be performed two times instead of three.
Acute mania following COVID-19 in a woman with no past psychiatric history case report
Authors: Sprenger Steven , Bare J. Pilar , Kashyap Rahul , Cardella Luigi 
Published: July 2022

Abstract
Background
The COVID-19 pandemic that began in late 2019 is caused by infection with the severe acute respiratory syndrome coronavirus-2. Since that time, many neuropsychiatric sequelae including psychosis, neurocognitive disorders, and mood disorders have been observed. The mechanism underlying these effects are currently unknown, however several mechanisms have been proposed.

Case presentation
A 47-year-old woman with past medical history including hypertension and premenstrual syndrome but no psychiatric history presented to the psychiatric hospital with new onset mania. She had developed symptoms of COVID-19 and was later diagnosed with COVID pneumonia. During quarantine, she reported high levels of stress, grief, and anxiety. Seventeen days into her illness, she developed altered mental status, sleeplessness, elevated mood, talkativeness, and preoccupations. Her spouse was concerned for her safety and contacted emergency medical services who brought her to the psychiatric hospital. She had not slept for five days prior to her arrival and exhibited flight of ideas, talkativeness, and grandiose ideas. She reported a family history of bipolar disorder but no past manic or depressive episodes. She was diagnosed with acute mania and stabilized using antipsychotics, a mood stabilizer, and a short course of a benzodiazepine. Many of her symptoms improved, including her elevated mood, increased activity level, and flight of ideas though she continued to have decreased need for sleep as her benzodiazepine was tapered. She and her partner were agreeable to transitioning to outpatient care after her mood stabilized.

Conclusions
This report emphasizes the link between COVID-19 and neuropsychiatric symptoms. Acute mania has no recognized association with COVID-19, but similar presentations have been reported. The patient’s age and time to onset of psychiatric symptoms is consistent with previous reports. Given the growing body of evidence, this association warrants further investigation. Severe acute respiratory syndrome coronavirus-2 causes systemic inflammation and has been shown to be neurotropic. In addition, patients undergoing quarantine experience anxiety related to the disease in addition to social isolation. Psychiatric practitioners should be aware of these effects and advocate for psychiatric evaluation following COVID-19 infection. Understanding the sequelae of infectious disease is crucial for responding to future pandemics.
Decreased lateral posterior tibial slope and medial tibial depth are underlying anatomic risk factors for posterior cruciate ligament injury: a case–control study
Authors: Yin Baoshan , Zhao Pei , Chen Jiaxing , Yan Wenlong , Zhang Hua , Zhang Jian , Zhou Aiguo 
Published: July 2022

Abstract
Objectives
To research whether medial PTS, lateral PTS and MTD were different between the PCL injury group and the PCL intact group.

Design
Retrospective case–control study, level of evidence III.

Methods
Fifty patients with PCL rupture from 2015 to 2020 in our hospital, and 50 patients matched by age and sex with intact PCL were enrolled in our study. The intraclass correlation coefficient (ICC) was used to assess the reliability of each parameter. The independent t-test was conducted to identify the differences in tibial morphometric characteristics between the PCL-injured and PCL-intact individuals, including the posterior tibial slope (PTS), meniscal slope (MS), medial tibial depth (MTD). A binary logistic regression model was established to evaluate the roles of those anatomic parameters of interest play in PCL injuries.

Results
The interobserver reliability of each parameter showed excellent agreement. Significant differences in the medial (P = .023) and lateral (P = .009) PTS were found between the PCL-injured group (3.68 ± 2.70 and 4.55 ± 3.19, respectively) and the controls (5.00 ± 2.73 and 6.39 ± 3.29, respectively). And the MTD was 1.98 ± 0.64 mm in the PCL-injured group and 2.37 ± 0.55 mm in the control group (P = 0.007). Binary logistic regression analysis showed that smaller lateral PTS and MTD were directly associated with PCL injury, with an OR of 1.17 and OR of 3.14, respectively. The medial PTS was independent to PCL injures.

Conclusion
Decreased lateral PTS and MTD were underlying anatomic risk factors for PCL injury.
Antibacterial and antibiotic-potentiation activity of the constituents from aerial part of Donella welwitshii (Sapotaceae) against multidrug resistant phenotypes
Authors: Guefack Michel-Gael F. , Ngangoue Marcelle O. , Mbaveng Armelle T. , Nayim Paul , Kuete Jenifer R. N. , Ngaffo Carine M. N. , Chi Godloves F. , Ngameni Bathelemy , Ngadjui Bonaventure T. , Kuete Victor 
Published: July 2022

Abstract
Background
The rise of multidrug-resistant (MDR) bacteria is a real public health problem worldwide and is responsible for the increase in hospital infections. Donella welwitschii is a liana or shrub belonging to the family Sapotaceae and traditionally used to cure coughs.

Objective
This study was conducted with the objective to validate the medicinal properties of this plant, the aerial part was studied for its phytochemical composition using column and PTLC chromatography and exploring its antibacterial and antibiotic-modifying activity as well as those of its phytochemicals.

Methods
The structures of the compounds were elucidated from their physical and spectroscopic data in conjunction with literature. The antibacterial activity of the isolated metabolites was performed toward a panel of MDR Gram negative and Gram-positive bacteria. The broth micro-dilution method was used to determine antibacterial activities, efflux pump effect using the efflux pump inhibitor (EPI) (phenylalanine-arginine-ß-naphthylamide (PAβN)), as well as the modulating activity of antibiotics. Monitoring the acidification of the bacterial growth medium was used to study the effects of the samples on the bacterial proton-ATPase pumps and cellular ATP production.

Results
Eleven compounds were isolated including pentacyclic triterpenes, C-glucosyl benzophenones. With a MIC value < 10 μg/mL, diospyric acid (7) significantly inhibited the growth of Escherichia coli AG102, Enterobacter aerogenes ATCC13048, Klebsiella pneumoniae KP55, Providencia stuartii NEA16 and Staphylococcus aureus MRSA3. 28-hydroxy-β-amyrin (8) significantly impaired the growth of Enterobacter aerogenes EA27, Klebsiella pneumoniae ATCC11296 and Staphylococcus aureus MRSA6; and oleanolic acid (9) strongly impaired the growth of Escherichia coli AG 102, Enterobacter aerogenes EA27 and Providencia stuartii PS2636. Diospyric acid (7) and 28-hydroxy-β-amyrin (8) induced perturbation of H+-ATPase pump and inhibition of the cellular ATP production. Moreover, at MIC/2 and MIC/4, compounds 7, 8, and 9 strongly improved the antibacterial activity of norfloxacin, ciprofloxacin and doxycycline with antibiotic-modulating factors ranging between 2 and 64.

Conclusion
The overall results of the current work demonstrate that diospyric acid (7), 28-hydroxy-β-amyrin (8) and oleanolic acid (9) are the major bioactive constituents of Donella welwitschia towards Gram-negative bacteria expressing MDR phenotypes.
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Authors: Tonomura Sotatsu , Ling Jennifer , Gu Jianguo G. 
Published: July 2022

AbstractPrevious immunohistochemical studies have shown the expression of KCNQ2 channels at nodes of Ranvier (NRs) of myelinated nerves. However, functions of these channels at NRs remain elusive. In the present study, we addressed this issue by directly applying whole-cell patch-clamp recordings at NRs of rat lumbar spinal ventral nerves in ex vivo preparations. We show that depolarizing voltages evoke large non-inactivating outward currents at NRs, which are partially inhibited by KCNQ channel blocker linopirdine and potentiated by KCNQ channel activator retigabine. Furthermore, linopirdine significantly alters intrinsic electrophysiological properties of NRs to depolarize resting membrane potential, increase input resistance, prolong AP width, reduce AP threshold, and decrease AP amplitude. On the other hand, retigabine significantly decreases input resistance and increases AP rheobase at NRs. Moreover, linopirdine increases excitability at NRs by converting single AP firing into multiple AP firing at many NRs. Saltatory conduction velocity is significantly reduced by retigabine, and AP success rate at high stimulation frequency is significantly increased by linopirdine. Collectively, KCNQ2 channels play a significant role in regulating intrinsic electrophysiological properties and saltatory conduction at NRs of motor nerve fibers of rats. These findings may provide insights into how the loss-of-function mutation in KCNQ2 channels can lead to neuromuscular disorders in human patients.
Hypoglycemic unawareness: challenges, triggers, and recommendations in patients with hypoglycemic unawareness: a case report
Authors: Sharifi Yasaman , Ebrahimpur Mahbube , Tamehrizadeh Seyed Saeed 
Published: July 2022

AbstractBackgroundHypoglycemia is a fairly common complication in diabetic patients, particularly in those on insulin therapy. Hypoglycemia symptoms are classified into two types: autonomic and neuroglycopenic symptoms. If a person develops neuroglycopenic symptoms before the appearance of autonomic symptoms or is asymptomatic until blood sugar levels are very low, the patient will develop hypoglycemic unawareness (HU).Case presentationA 25-year-old Iranian woman with HU presented with a severe hypoglycemic episode. This episode was characterized by loss of consciousness and focal neural deficits, which were unusual symptoms in the patient, who was a medical intern with type 1 diabetes and currently being treated with regular and NPH insulin.ConclusionsHypoglycemia is a common complication in diabetic patients receiving oral or insulin therapy. A patient who is unaware of their condition may experience severe and potentially fatal episodes. These incidents can negatively affect their daily lives as well as their careers and jobs. Hypoglycemia-associated autonomic failure is a possible cause for patients with multiple episodes of severe hypoglycemia. IThe use of a continuous glucose monitoring device with an alarm, if available, can be an excellent option for these patients.
Ionospheric signatures of repeated passages of atmospheric waves by the 2022 Jan. 15 Hunga Tonga-Hunga Ha’apai eruption detected by QZSS-TEC observations in Japan
Authors: Heki Kosuke 
Published: July 2022

AbstractA large eruption occurred on Jan. 15, 2022, at the submarine volcano Hunga Tonga-Hunga Ha’apai, southern Pacific, and the atmospheric Lamb wave was observed to have traveled round the Earth multiple times with a speed of ~ 0.3 km/s. Here, I compare their ionospheric and atmospheric signatures using data from dense arrays of barometers and GNSS stations in Japan. I confirmed that the ionospheric disturbances passed over Japan at least four times, first from SE to NW, then from NW to SE, again from SE to NW, and finally from NW to SE. The propagation velocity of the ionospheric disturbances was as fast as the atmospheric Lamb wave, suggesting their origin as upward energy leakage from the troposphere. The first passage of the ionospheric disturbance started prior to the arrival of the Lamb pulse, but its physical mechanism is yet to be explored. Unlike the barometric records, waveforms and amplitudes of ionospheric disturbances exhibit large diversity along the wavefront, suggesting their turbulent nature.

Graphical Abstract
Decoupling between soil moisture and biomass drives seasonal variations in live fuel moisture across co-occurring plant functional types
Authors: Brown Tegan P. , Hoylman Zachary H. , Conrad Elliott , Holden Zachary , Jencso Kelsey , Jolly W Matt 
Published: July 2022

Abstract
Background
Wildfires are important global disturbances influencing ecosystem structure and composition. The moisture content of living and senescent plant components are key determinants of wildfire activity, yet our understanding of how seasonal fluctuations in water availability and biomass control live foliar moisture content (LFMC) across co-occurring plant functional types is limited in diverse forested landscapes.

Results
We recorded root-zone volumetric water content (VWC) and sampled leaf mass area (LMA) and LFMC of three co-occurring plant functional types across six field sites. We used a linear mixed effects model to quantify the drivers of LFMC and understand whether LFMC dynamics were coupled or decoupled from site conditions. Both LMA and VWC were significant predictors of LFMC variability (p < 0.001), although the strength and direction of these relationships varied across functional types. LFMC dynamics of understorey plant functional types were strongly coupled to site conditions, where the site random effect explained 44.2% (shrub) and 74.8% (herb) of the variability in LFMC across the season respectively. In contrast, overstorey plants were decoupled from site conditions, which explained only 8.1% of the variability in LFMC.

Conclusions
LFMC of understorey plants responded to changes in soil water availability (VWC), while overstorey trees responded to biomass fluctuations (LMA). We present a conceptual model describing the influence of these factors on LFMC, which aligns with our findings and draws on the broader literature. This knowledge and conceptual approach can be used to improve our ability to characterize seasonal LFMC variation across different plant functional types, in turn improving our capacity to predict wildfire risk.
Effect of intradialytic exercises (IDE) on maximal oxygen consumption and quality of life undergoing hemodialysis in Indian population—a pilot study
Authors: Grover Seema , Goyal Vaishali , Chorsiya Varsha , Ganguly Nirmal Kumar , Saha Gautam Kumar 
Published: July 2022

Abstract
Background
End stage renal disease (ESRD) is emerging as a major health issues across developing countries with limited access and awareness about the importance of exercises in daily life. People on prolong hemodialysis has difficulty in performing their activities of daily living (ADL). Loss of muscle mass is inevitable among patients on hemodialysis that leads to morbidity and mortality. Exercise is feasible during dialysis and can enhance quality of life. Increase in aerobic endurance by various combined protocol of aerobic and resistive exercises can improve compliance to regular exercise that underlines the theme of present study.

Methods
A total of 31 participants were recruited during November 2019 to February 2020, after screening of 65 participants for selection criteria from Indraprastha Apollo Hospital’s dialysis unit. The average age of the participants was 52.36 ± 11.56 years. A single-blinded, pre-test–post-test quasi-experimental clinical trial for intradialytic exercise program involving lower limb ergometer and resistance training for lower limbs and non-fistula hand for 24 sessions, in 3 months, twice a week was conducted.

Results
The exercise program was well tolerated and all patients completed it. Aerobic and resistance intradialytic exercises (IDE) had a positive effect on maximal oxygen consumption (VO2 Max), quality of life (SF 36), and sleep quality (PSQI). IDE showed statistically significant difference from pre- to post-intervention for maximal oxygen consumption, quality of life boosting their sleep quality.

Conclusions
IDE found to benefit the patient and results showed a significant improvement in maximal oxygen consumption, sleep quality, quality of life and fatigue over a span of 12 weeks.

Trial registration
CTRI, CTRI/2019/08/020848. Registered on 22 August 2019.
Responder Analysis of Pain Relief After Surgery for the Treatment of Spinal Metastatic Tumors
Authors: Rothrock Robert J. , Reiner Anne S. , Barzilai Ori , Kim Nora C. , Ogilvie Shahiba Q. , Lis Eric , Gulati Amitabh , Yamada Yoshiya , Bilsky Mark H. , Laufer Ilya 
Published: July 2022

BACKGROUND:
Central tendency analysis studies demonstrate that surgery provides pain relief in spinal metastatic tumors. However, they preclude patient-specific probability of treatment outcome.

OBJECTIVE:
To use responder analysis to study the variability of pain improvement.

METHODS:
In this single-center, retrospective analysis, 174 patients were studied. Logistic regression modeling was used to associate preoperative characteristics with rating the Brief Pain Inventory (BPI) worst pain item 0 to 4. Linear regression modeling was used to associate preoperative characteristics with minimal clinically important improvement (MCI) in physical functioning defined by a 1-point decrease in the BPI Interference Construct score from preoperative baseline to 6 months postoperatively.

RESULTS:
Patient-level analysis revealed that 60% of patients experienced an improvement in pain. At least half experienced a decrease in pain resulting in MCI in physical functioning. Cutpoint analysis revealed that 48% were responders. Increasing scores on the preoperative pain intensity BPI items, the MD Anderson Symptom Inventory (MDASI) Core Symptom Severity Construct, the MDASI Spine Tumor–Specific Construct, the presence of preoperative neurologic deficits, and postoperative complications were associated with lower probability of treatment success while increasing severity in all BPI pain items, and MDASI constructs were associated with increased probability of MCI in physical function. Significant mortality and loss to follow-up intrinsic to this patient population limit the strength of these data.

CONCLUSION:
Although patients with milder preoperative symptoms are likely to achieve better pain relief after surgery, patients with worse preoperative symptom also benefit from surgery with adequate pain relief with an improvement in physical function.
Ordered Silica Nanostructure by the Calcination of Block Copolymer with Polyhedral Oligomeric Silsesquioxane (POSS) Side Chain
Authors: Iwao Sota , Kurono Naoki , Higashiguchi Wataru , Hayakawa Teruaki , Ohta Noboru , Kamitani Kazutaka , Fujii Syuji , Nakamura Yoshinobu , Hirai Tomoyasu 
Published: July 2022

Abstract
Silica with well-ordered line patterns and a periodicity of approximately 30 nm was prepared by the calcination of a block copolymer with polyhedral oligomeric silsesquioxane (POSS) as a template. A POSS-containing block copolymer was prepared via living anionic polymerization. The thin film of the block copolymer exhibited linear features upon CS2 vapor annealing. Cylindrical structure changed to a line morphology during calcination process.