bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Function of Connection: Examining Social Supports in the Lives of Parentally Bereaved Youth
Authors: Schaefer Lauren M. , Howell Kathryn H. , Jamison Lacy E. , Napier Taylor R. 
Published: September 2022

Through reflexive thematic analysis, this study explored three forms of social support in the lives of parentally bereaved youth: support derived from one’s spirituality, caregiver support via parent-child communication, and therapist support from grief counseling ( N = 30 youth, M age = 12.5 years, SD = 2.8 years). Results showed that these sources of support serve varied and vital functions in the lives of parentally bereaved youth. Namely, the benefits of grief counseling and spirituality were consistently identified by youth as critical in facilitating their coping with the loss of a parent; while parent-child communication regarding the deceased varied widely, highlighting the need for additional supports beyond their surviving caregiver. Findings also revealed differences among these supports across youth gender, race, ethnicity, and age. Adolescents were more likely to disengage from counseling services and reported less parental and spiritual support. Males and minoritized youth experienced more benefits from spiritual and therapist supports.
The role of hyaluronic acid in polidocanol foam: An in vitro study
Authors: Ziyi Liu , Xuanxuan Shi , Dongjian Li , Azmoun Sajjad , Shaohua Liu 
Published: September 2022

Objective To study the role of hyaluronic acid (HA) in polidocanol (POL) foam. Methods The dose-dependent effect of HA-POL on cultured human umbilical vein endothelial cells (HUVECs) as well as foam stability was evaluated by measuring optical density (OD) values and foam half-life time (FHT), respectively. An in vitro model was utilized for estimating the foam blood-displacement capacity by adopting maximum displacement distance (MDD) and displacement time. A comparison of foam viscosity was also carried out. Results The OD values of HUVECs treated with HA first increased and then decreased with the growing dosage of HA while cells treated with HA-POL died. Both FHT and displacement time were prolonged statistically with a gradually enhanced foam viscosity. As to MDD, there were no significant differences. Conclusions HA was found to promote HUVECs proliferation slightly, but this was almost negligible when compared to the cell-killing capacity of 1% POL. The viscosity of POL foam was enhanced by HA indicating its positive correlation with both stability and displacement capacity of POL foam.
A manikin study comparing the performance of traditional Macintosh laryngoscope, GlideScope®, Airtraq®, and video‐optical intubation stylet in endotracheal intubation used by emergency doctors in simulated difficult airway intubation: A pilot study
Authors: Li Yu On , Wong Oi Fung , Ko Shing , Ma Hing Man , Lit Chau Hung Albert , Shih Yau Ngai 
Published: September 2022

Background:The video‐optical intubation stylet (VS) is a slim, rigid but flexible intubating device that aids physicians to intubate patients, particularly with difficult airways.Objectives:The objective of this study was to compare the performance of emergency department doctors in using different intubating devices for intubation in an airway manikin simulating different difficult airway scenarios.Methods:Thirty emergency department doctors were recruited in a pilot study. Their performance of using traditional Macintosh laryngoscope, GlideScope®, Airtraq® and C‐MAC® Video Stylet were compared in three situations: normal, restricted cervical motion and limited oral aperture. The time for intubation, first attempt success rate, failure rate, dental injury and the subjective ease of different devices by the participants were compared.Result:The mean intubation time by VS in each scenario was significantly shorter compared with other devices (Normal: 19.77s vs 24.67–28.19s, p = 0.014; Cervical restriction: 20.85 vs 26.17–31.26s, p = 0.008; Limited oral aperture:19.03 vs 29.35, p = 0.001). However, there was no significant difference in failure rate or first attempt success rate. The incidence of dental injury was significantly lower with VS than other laryngoscopes (p = 0.001, p < 0.05 and p < 0.05 in normal, cervical restriction and limited oral aperture scenarios, respectively). Moreover, participants appreciated that VS was the easiest device to intubate in each scenario. (p < 0.05 in all scenarios)Conclusion:The performance of VS was comparable to or even better than the commonly used laryngoscopes in the emergency department in airway management. When adequate training is provided, VS can be a potentially good alternative for tracheal intubation in different situations.
Let’s Talk About Dying: An Educational Pilot Program to Improve Providers’ Competency in End-Of-Life Discussions
Authors: Kaminski Ashley 
Published: September 2022

Introduction Advance care planning (ACP) conversations occur infrequently due to lack of provider confidence-level, education, and workplace support for gaining skills in initiating goals of care and end-of-life discussions. Methods A 3-month quality improvement project was carried out between October 2021 to January 2022 using a short, accessible virtual presentation on provider initiation of goals of care conversations. A pre-test/post-test design was implemented using the End-of-Life Professional Caregiver Survey and frequency of ACP documentation of surgical intensive care unit providers. Results Over the study period, 17 providers reviewed the virtual presentation. The End-of-Life Professional Caregiver Survey sum score increased significantly from pre-to post-test ( P < .001) reflecting increased provider confidence in initiating goals of care conversations. There was also significant increase in ACP documentation from pre-intervention to the third and final monthly cycle. Discussion Structured education increased ICU providers confidence in having goals of care conversations and improved the frequency of ACP documentation.
Reasons for Discordance Between Life-Sustaining Treatment Preferences and Medical Orders in Nursing Facilities Without POLST
Authors: Heim Smith Nicholette L. , Sudore Rebecca L. , Myers Anne L. , Hammes Bernard J. , Hickman Susan E. 
Published: September 2022

Background Life-sustaining treatment (LST) orders are important communication tools used to ensure preference-concordant care at the end of life. Recent studies reveal concerning rates of discordance between current preferences and documented LST orders, especially in nursing facilities without POLST. Reasons for discordance in facilities using POLST have been explored, however the majority of nursing facilities in the United States do not yet use the POLST form. Design Qualitative descriptive study using constant comparative analysis. Setting Nursing facilities in Indiana ( n = 6) not using POLST. Participants Residents ( n = 15) and surrogate decision-makers of residents without decisional capacity (n = 15) with discordance between current preferences and documented LST orders. Measurements Do not resuscitate, do not hospitalize (DNH), and do not intubate (DNI) orders were extracted from medical charts. Current preferences were elicited using the Respecting Choices Advanced Steps model. A semi-structured interview guide was used to explore reasons for discordance between current preferences and LST orders. Results Reasons for discordance included: (1) inadequate information about the range of available LST options, what each involves, and how to formally communicate preferences; (2) no previous discussion with facility staff; (3) no documentation of previously expressed preferences; and (4) family involvement. Conclusion Reasons for discordance between expressed preferences and LST orders suggest that in facilities without a uniform and systematic LST order documentation strategy like POLST, these conversations may not occur and/or be documented. Staff should be aware that residents and surrogates may have preferences about LSTs that require strategic solicitation and documentation.
Magnitude of Work-Related Musculoskeletal Disorders and its Associated Factors Among Computer User Bankers in South Gondar Zone, Northwest Ethiopia, 2021
Authors: Demissie Biruk , Yenew Chalachew , Amsalu Alebachew , Yideg Yitbarek Getachew , Dagnew Baye Nega , Walle Gashaw , Asnakew Sintayehu , Minuye Binyam , Tadele Adimasu Fitalew , Tilahun Mulu Anemut , Sisay Ermias , Teshome Dagnaw Fentaw , Tegegne Eniyew 
Published: September 2022

Introduction: Musculoskeletal disorders (MSDs), which are the leading cause of workplace health problems; affect workers, employers, and society as a whole following direct and indirect cost. Bankers are expected to perform at computer workstations for long periods of time. As a result, they are at risk of developing musculoskeletal disorders. Hence, this study intends to assess magnitude of work related musculoskeletal disorders and its predictors among computer user bankers in this study area. Material and methods: Institutional based cross-sectional study was conducted from September to December 2021. A total of 422 private and Public own computer user bankers were participated. Simple random sampling technique was used to select the study participants. Binary logistic regression model was used to investigate the relationship between dependent and independent variables. P value less than .05 at 95% CI was considered as a significant association between dependent and independent variables. Result: Overall, 245 (58.8%) of computer-user bankers were suffered work-related musculoskeletal disorders in the previous 12 months. Aged 30 and above [AOR:6.5 (1.7-24.6)], no regular physical exercise [AOR: 6.03 (2.2-16.3)], not received ergonomics training [AOR: 5.46 (2.2-13.1)] and working in awkward posture [AOR: 8.76 (2.9-25.9)] were significantly associated to work related musculoskeletal disorders in the previous 12 months. Conclusion: The magnitude of musculoskeletal disorders among computer user bankers was high. Implementing proper working posture, regular physical exercise, avoiding prolonged use of computer and receiving ergonomics training will reduce the burden of musculoskeletal disorders among computer user bankers. The implications of the findings enhance the need for training supervision, cascading tasks taking the age of workers in to account, sustained supply of work station materials and promoting physical exercise by banks to their workers uninterruptedly.
Antimuscarinics for neurogenic overactive bladder in multiple sclerosis: real-life data
Authors: Andretta Elena , Finazzi Agrò Enrico , Calabrese Massimiliano , Orecchia Luca , Furlan Antonietta , Zuliani Cristina 
Published: September 2022

Background: Antimuscarinics (AMs) represent the mainstay of treatment for storage lower urinary tract symptoms (LUTS) but few data are available on their impact in multiple sclerosis (MS) patients. Objective: To assess effectiveness and tolerability of AMs in MS patients with neurogenic detrusor overactivity (NDO). Methods: Sixty consecutive outpatients, who started treatment with AMs at one centre, were recruited. The primary endpoint was change in Patient’s Perception of Intensity of Urgency Scale (PPIUS) at 6 months; secondary endpoints were post-void residual urine (PVR) and pads used daily. Incidence and severity of adverse events (AEs) were recorded. Results: Significant reduction ( p < 0.001) of mean PPIUS and pads use were detected, as well as a significant increase ( p < 0.001) of PVR (143 ± 42 ml). AEs, recorded in 53% of patients, were frequently multiple and caused suspension of AM in 10% of cases, mainly for xerostomia, which has been the commonest AE (26.6%). Neurological AEs appeared in 11.7% of subjects, mostly with oxybutynin. Worsening/onset of voiding LUTS, reported by 8.3% of MS, resulted to be the unique AE correlated to AM dosage. Conclusion: This study suggests that AMs are effective in MS patients, but their use should be tailored on every patient as even low dosages can be poorly tolerated. AEs, including neurological ones, are common.
Seasonal Variations in the Effectiveness of Immersive Virtual Nature
Authors: Litleskare Sigbjørn , Calogiuri Giovanna 
Published: September 2022

Aim: The aim of this study was to assess whether the outcomes of immersive virtual nature (IVN) varies between seasons. Background: IVN has received increased interest in recent years due to its potential applications within health and design. However, factors influencing people’s responses to IVN are largely unknown. Seasons affect a variety of human processes and behaviors including levels of affect and blood pressure, also in the context of human–nature interactions. These seasonal variations might influence how people interact and respond to IVN, especially since IVN allow for representations of nature that are not representative of the current real-life season. Methods: A secondary analysis of data retrieved from two previous studies, which included three IVN conditions, was conducted. All IVNs represented late spring conditions. Measures included perceived environmental restorativeness, affect, enjoyment, heart rate, and blood pressure. A meta-analytic approach was used to assess whether there were consistent differences between participants who were exposed to the IVN in spring/summer (early June to mid-September) and autumn/winter (mid-September to December) across the three different conditions. Results: There was a consistent effect of season only for one component of affect (fatigue), with larger reductions in fatigue when exposed to IVN during autumn/winter compared to spring/summer. No other significant effects of season were observed. Conclusion: IVNs are feasible to use across all seasons but might be more effective in reducing the feeling of fatigue during autumn and winter compared to other seasons.
A quality improvement initiative for patient knowledge comprehension during the discharge procedure using a novel computer-generated patient-tailored discharge document in cardiology
Authors: de Wit André , de Heide John , Cummins Paul , van Bruchem-van de Scheur Ada , Bhagwandien Rohit , Lenzen Mattie 
Published: September 2022

Objective The duration of hospital admissions has shortened significantly. This challenges healthcare professionals to provide the necessary information and instructions in a limited time. Patient-tailored discharge information may improve the patient's understanding of the discharge information but may also be time-consuming. The objective of this descriptive quality improvement study was to evaluate patient comprehension of discharge information using a novel computer-generated patient-tailored discharge document. Methods A prospective pre-post study comparing patient-tailored discharge information with conventional discharge information, for patients undergoing an electrophysiological procedure during two periods of six weeks between January and March 2016. Group I received conventional discharge information ( n  =  55). Group II received a computer-generated, patient-tailored discharge document ( n  =  57). Their comprehension of the discharge information was evaluated using a peer-reviewed questionnaire distributed among patients, comparing groups I and II using Likert scales. Nurses and nurse practitioners evaluated the use of personalized discharge information by means of a short survey. Results In terms of discharge information, comprehensibility was equivalent; however, an increase in comprehension was observed in patients seeking a telephone consultation with the cardiology department within one-week post-discharge. A reduction in discharge preparation time and an increased uniformity of discharge information were reported by nurses. Nurse practitioners found the web tool easy to use and time-saving. Conclusions In this study, computer-generated patient-tailored discharge information was equivalent to conventional discharge information. A more positive trend was seen for patients who initiated teleconsultation with the hospital within one-week post-discharge. This suggests that for this subgroup the patient-tailored discharge web tool might lead to an improvement in care. However, more research with a larger number of participants is needed to confirm this trend.
Perception of Clinical Authority in LGBTQIA+ Mental Health Service Users: An Exploration Through Projective Storytelling and Experiential Narratives
Authors: Chatterjee Aritra , Dasgupta Manisha 
Published: September 2022

Background: There is a tendency to use projective assessment to single out intrapsychic vulnerabilities of LGBTQIA+ individuals in mental health literature, without giving due weightage to their marginalized contexts. Additionally, their experiences in accessing mental health services are often nonaffirmative due to dominant pathological discourses in mainstream settings, even though scientific-clinical consensus has been explicit about depathologization. Objectives: The current study aims to understand implicit perceptions and attitudes toward clinical authority in a sample of 10 self-identified LGBTQIA+ mental health service-users in Kolkata. It also aims to contextualize the same against their lived experiences of mental health-care use. Methodology: Qualitative method was used in the current study. Data was collected with the help of sociodemographic questionnaire (for identifying social locations of participants), semi-structured interviews (for eliciting lived experiences of clinical relationships in mental health care), and projective storytelling with the help of TAT Cards 1 and 12M. Results: Analysis of projective storytelling reveals predominantly negative perception of clinical authority with prominent themes of being overpowered by authority, dilemma regarding clinical outcome, passivity, sexual violation, and extreme perceived hostility from environment. Such perception is explainable in the light of lived experiences of discrimination in mental health care, personal vulnerabilities, lack of wholesome interpersonal relationships, and being victims of dominant pathologizing discourses in mental health sciences. Conclusion: Mental health-care praxis needs to direct its attention to discriminatory experiences of service-users from gender and sexual minorities. Practitioners must be encouraged to develop specific competency in this regard, and be mindful of their own biases and prejudice when interacting with clients. JEL Classification:
RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
Authors: Fraga de Andrade Isabela , Johnson Kirby D. , Mehta Charu , Dewey Colin N. , Basu Uttiya , Bresnick Emery H. 
Published: September 2022

Abstract
The RNA-regulatory exosome complex (EC) posttranscriptionally and cotranscriptionally processes and degrades RNAs in a context-dependent manner. Although the EC functions in diverse cell types, its contributions to stem and progenitor cell development are not well understood. Previously, we demonstrated that the transcriptional regulator of erythrocyte development, GATA1, represses EC subunit genes, and the EC maintains erythroid progenitors in vitro. To determine if this mechanism operates in vivo, we used the hematopoietic-specific Vav1-Cre and “conditional by inversion” mouse system to ablate Exosc3, encoding an EC structural subunit. Although Exosc3C/C Cre+ embryos developed normally until embryonic day 14.5, Exosc3 ablation was embryonic lethal and severely reduced erythromyeloid progenitor activity. RNA sequencing analysis of Exosc3-ablated burst-forming unit-erythroid revealed elevated transcripts encoding multiple proapoptotic factors, and the mutant erythroid progenitors exhibited increased apoptosis. We propose that the EC controls an ensemble of apoptosis-regulatory RNAs, thereby promoting erythroid progenitor survival and developmental erythropoiesis in vivo.
The impact of seat height on 1-min sit-to-stand test performance in COPD: a randomised crossover trial
Authors: Zumbrunnen Valerie , Riegler Thomas F. , Haile Sarah R. , Radtke Thomas 
Published: September 2022

Study questionIs there a difference in the number of repetitions in the 1-minute sit-to-stand (1MSTS) test using an individually adapted seat height to 90° knee flexion (1MSTSIND), compared with the commonly used standard chair seat height of 46 cm (1MSTSSTD), in people with COPD?MethodsWe conducted a single-centre, single-blinded, randomised crossover trial in people with COPD between August 2020 and March 2021 at a specialised rehabilitation clinic in Switzerland. After a learning 1MSTS test, all participants performed two 1MSTS tests in random order on consecutive days. Participants were blinded, as they did not receive detailed information on the testing protocols.Results49 individuals with COPD (47% female) participated. In a regression model adjusted for sequence period and subject, 1MSTS test performance was lower on 1MSTSINDcompared to 1MSTSSTD(−0.78 repetitions, 95% CI −1.47 to −0.11). In a second regression model additionally including the knee angle and an interaction term (1MSTSIND×knee angle), the interaction term was significant: 0.18 (95% CI 0.05 to 0.30). The limits of agreement were between −5.5 and 4 repetitions.ConclusionAlthough we observed a statistically significant difference between 1MSTSINDand 1MSTSSTDon a population level, the difference is negligible. Further studies may be needed to determine whether individual adaptation of seat height is needed for very tall or short people to ensure a valid assessment of 1MSTS test performance in COPD.
Effects of functional training with blood occlusion on the irisin, follistatin, and myostatin myokines in elderly men
Authors: Pazokian Fatemeh , Amani-Shalamzari Sadegh , Rajabi Hamid 
Published: September 2022

AbstractBackgroundThis study aimed to determine the efficacy of functional training with and without blood flow restriction (BFR) on muscle hypertrophy indices and strength in older men.MethodsThirty older adults (67.7 ± 5.8 years) were randomly assigned to three groups: functional training (FT), functional training with BFR (FTBFR), and control (C). Participants in experimental groups were trained in three sessions per week for six weeks. They performed 11 whole body exercises, in 2–4 sets of 10 repetitions. FTBFR group wore pneumatic cuffs on their extremities that began with 50% of estimated arterial occlusion pressure which increased by 10% every two weeks. Blood samples were obtained, and static strength tests were evaluated at baseline and after the training program. A One-Way Analysis of Covariance was used to interpret the data.ResultsA significant increase in follistatin levels (p = 0.002) and reduction in myostatin levels (p = 0.001) were observed in FT and FTBFR groups; there was a considerable increase in the F:M ratio in both training groups (p = 0.001), whereas it decreased in C group. These changes were accompanied by significant improvements in handgrip (p = 0.001) and shoulder girdle (p = 0.001) strength in both experimental groups, especially in the FTBFR group. However, the levels of irisin were not statistically changed following interventions (p = 0.561).ConclusionThe findings showed that FT was effective in increasing circulating biomarkers involved in hypertrophy in older adults while adding BFR to FT had a slight increase in these biomarkers but had a tremendous increase in muscle strength.