bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative functional analysis uncovers metabolic differences between Candida species
Authors: Begum Neelu , Lee Sunjae , Portlock Theo John , Pellon Aize , Nasab Shervin Dokht Sadeghi , Nielsen Jens , Uhlen Mathias , Moyes David L. , Shoaie Saeed 
Published: September 2022

AbstractCandidaspecies are a dominant constituent of the human mycobiome and associated with the development of several diseases. Understanding theCandidaspecies metabolism could provide key insights into their ability to cause pathogenesis. Here, we have developed the BioFung database, providing an efficient annotation of protein-encoding genes. Along, with BioFung, using carbohydrate-active enzyme (CAZymes) analysis, we have uncovered core and accessory features acrossCandidaspecies demonstrating plasticity, adaption to the environment and acquired features. We show a greater importance of amino acid metabolism, as functional analysis revealed that allCandidaspecies can employ amino acid metabolism. However, metabolomics revealed that only a specific cluster of species (AGAu species—C. albicans, C. glabrataandC. auris) utilised amino acid metabolism including arginine, cysteine, and methionine metabolism potentially improving their competitive fitness in pathogenesis. We further identified critical metabolic pathways in the AGAu cluster with biomarkers and anti-fungal target potential in the CAZyme profile, polyamine, choline and fatty acid biosynthesis pathways. This study, combining genomic analysis, and validation with gene expression and metabolomics, highlights the metabolic diversity with AGAu species that underlies their remarkable ability to dominate they mycobiome and cause disease.
Kinetics of phagosome maturation is coupled to their intracellular motility
Authors: Yu Yanqi , Zhang Zihan , Walpole Glenn F. W. , Yu Yan 
Published: September 2022

AbstractImmune cells degrade internalized pathogens in phagosomes through sequential biochemical changes. The degradation must be fast enough for effective infection control. The presumption is that each phagosome degrades cargos autonomously with a distinct but stochastic kinetic rate. However, here we show that the degradation kinetics of individual phagosomes is not stochastic but coupled to their intracellular motility. By engineering RotSensors that are optically anisotropic, magnetic responsive, and fluorogenic in response to degradation activities in phagosomes, we monitored cargo degradation kinetics in single phagosomes simultaneously with their translational and rotational dynamics. We show that phagosomes that move faster centripetally are more likely to encounter and fuse with lysosomes, thereby acidifying faster and degrading cargos more efficiently. The degradation rates increase nearly linearly with the translational and rotational velocities of phagosomes. Our results indicate that the centripetal motion of phagosomes functions as a clock for controlling the progression of cargo degradation.
The combination of sodium alginate and chlorogenic acid enhances the therapeutic effect on ulcerative colitis by the regulation of inflammation and the intestinal flora
Authors: Niu Wei , Chen Yuxuan , Wang Ligui , Li Jia , Cui Zhao , Lv Jiajie , Yang Fuyan , Huo Jiege , Zhang Zhenhai , Ju Jianming 
Published: September 2022

The combination of sodium alginate (SA) and chlorogenic acid (CA) enhances the therapeutic effect on ulcerative colitis by the regulation of inflammation and the intestinal flora.
Cellular and structural insight into dynamin function during endocytic vesicle formation: a tale of 50 years of investigation
Authors: Perrais David 
Published: September 2022

Abstract
Dynamin is one of the major proteins involved in endocytosis. First identified 50 years ago in a genetic screen in Drosophila melanogaster, it has become a central player in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis, as well as other important cellular processes such as actin remodelling. Decades of work using biochemical and structural studies, cell-free assays, live cell imaging, acute inhibition and genetic studies have led to important insights on its mode of action. Dynamin is a remarkable mechano-GTPase, which can do a lot to membranes on its own but which is, in cells, at the centre of a vast protein and lipid network and cannot work in isolation. This review summarizes the main features of dynamin structure and function and its central role in membrane remodelling events, and give an update on the latest results.
Bilateral association tracking with parzen window density estimation
Authors: Xu Yuan , Chen Youyuan , Zhang Yang , Zhu Qunxiong , He Yanlin , Sheng Hao 
Published: September 2022

AbstractMulti‐object tracking is an important branch of computer vision, which is mostly used for behavior recognition and event analysis. At present, most of the research focuses on the accuracy of tracking. However, the real‐time performance is also urgently desired but there is lack of research. As a result, Deepsort, proposed 5 years ago, is still the most widely used tracker in real applications. In this paper, a Bilateral Association Tracking (BAT) framework is proposed. It uses tracklet as the basic node instead of discrete detection for tracking. Meanwhile, a Parzen density based Hierarchical Agglomerative Clustering (P‐HAC) algorithm is introduced to describe the density distribution of targets and generate tracklets with high confidence. In addition, Dual Appearance Features (DAF) is proposed which considers both spatial and temporal features of tracklets and promotes the accuracy of tracklet association. Experiments are conducted on popular benchmarks such as MOT2017, Visdrone and KITTI. BAT outperforms Deepsort on both association accuracy and trajectory integrity without obvious efficiency decline. Compared with other state‐of‐the‐art trackers, BAT shows significant advantage on computational cost while performing competitive tracking accuracy as well. It is hoped that the research can promote the applications on real‐time tracking in the near future.
Compact UHF RFID balun‐like integrated tag antenna for long range detection of water bottles
Authors: Garg Manoj , Sharma Ashwani , Garcia Zuazola Ignacio J. , Gupta Arjit 
Published: September 2022

AbstractA compact, flexible, long‐range, and impedance transformer balun‐like integrated UHF RFID tag antenna is proposed for the detection of water bottles. To alleviate the performance of a tag antenna in close proximity to a high dielectric material such as water, the radiating element of the tag antenna uses folded, unbalanced strips made of balun‐like arms wrapped around the tag's body. As a result, a wide bandwidth with reasonably good radiation resistance is achieved. The tag's body comprises dual loops for the impedance matching to the tag chip. This leads to a long read range of 13.33 m; >5.83 m compared to other state‐of‐the‐art designs. The proposed tag antenna conforms to a small footprint by wrapping the balun‐like arms around the tag's body, which results in a compact form. The tag is fabricated, and the results reasonably agree with simulations.
Modified manta ray foraging optimization algorithm based improved load frequency controller for interconnected microgrids
Authors: Ahmed Emad M. , Selim Ali , Mohamed Emad A. , Aly Mokhtar , Alnuman Hammad , Ramadan Husam A. 
Published: September 2022

AbstractThe recent environmental crisis and global warming have compelled an energy transition, particularly in the power generation and transportation sectors. Increased energy competence and production will necessitate enormous efforts. Admittedly, power system inertia metrics have revealed reduced inertia attributes, which could lead to a catastrophic shutdown and security issues in future electrical power systems. The design of the load frequency controller is essential for improving frequency regulation and power system stability. Nonetheless, more research is needed into control development and design approaches that take into account renewable energy characteristics, complexities, connected electric vehicles (EVs), and uncertainties. Metaheuristic‐based design methods and fractional order control have recently demonstrated an improved response when compared to classical design methods and integer‐order controllers. This work presents an improved fractional order hybrid control system based on two modified versions of the Manta Ray Foraging Optimization (MRFO) Algorithm. The exploration and exploitation stages of the modified MRFO are enhanced by utilizing a chaotic map and a weighting factor. The transients and steady‐state performance of the studied two‐areas interconnected microgrids have been significantly improved by incorporating the advantages of both the suggested fractional order‐based control approach and the proposed modified MRFO algorithms. While assessing the feasibility of the developed controller and modified optimizers, uncertainty, renewable energy fluctuations, load transients, and electric vehicle attributes are all properly considered. The modified MRFO's performances are evaluated using 23 benchmark functions, and the results are compared to the original MRFO and recent well‐known optimization algorithms. Both statistical analysis and time‐domain results demonstrate the superiority of the proposed modified optimizers and the proposed load frequency controller.
HARPS radial velocity search for planets in the Scorpius-Centaurus association
Authors: Grandjean A. , Lagrange A.-M. , Meunier N. , Chauvin G. , Borgniet S. , Desidera S. , Galland F. , Kiefer F. , Messina S. , Iglesias D. , Nicholson B. , Pantoja B. , Rubini P. , Sedaghati E. , Sterzik M. , Zicher N. 
Published: September 2022

Context. The Scorpius-Centaurus (Sco-Cen) young and nearby massive star-forming region is particularly well suited for extrasolar planet searches with both direct imaging and radial velocity (RV) techniques. The RV search, however, is challenging, as the stars are faster rotators on average than their older stellar counterparts of similar spectral types. Moreover, the RV time series show strong signatures of stellar variability (spots and faculae) and/or stellar pulsations.
Aims. Our aim is to search for giant planets (GPs) and brown dwarfs at short orbital distances around star members of the Sco-Cen association. We also aim at using these data together with others available on young stars to estimate the GP occurrence rate for young stars for periods of up to 1000 days.
Methods. We used the High Accuracy Radial velocity Planet Searcher (HARPS) spectrograph on the 3.6 m telescope at the La Silla Observatory to monitor 88 A – F Sco-Cen stars. To improve our statistics and analysis, we combined this survey with two previous surveys that focused on young nearby stars (YNS) to compute companion occurrence rates from a sample of 176 young A – M stars.
Results. We report the discovery of a massive hot-Jupiter candidate around HD 145467, together with the discovery of one probable short-period (P < 10 days) brown dwarf around HD 149790. In addition, we confirm the binary nature of eight single-line binaries: HD 108857, HD 108904, HD 111102, HD 114319, HD 121176, HD 126488, HD 126838, and HD 133574. From our sample, we obtain a GP (mc ∈ [1; 13] MJup) occurrence rate of 0.7−0.2+1.6% for periods between 1 and 1000 days and a brown dwarf (mc ∈ [13; 80] MJup) occurrence rate of 0.6−0.2+1.4%, in the same period range. In addition, we report a possible lack of close (P ∈ [1; 1000] days) GPs around young F-K stars compared to their older counterparts, with a confidence level of 95%.
Supportive Ernährungstherapie für onkologische
PatientInnen während der Behandlungsphase
Authors: Erickson Nicole , Saraç Zeynep , Frank NicolePedros 
Published: September 2022

ZusammenfassungInsbesondere für onkologische PatientInnen besteht während der
Therapiephase ein erhöhtes Risiko für eine reduzierte
Flüssigkeits-, Energie- und Nährstoffzufuhr, was wiederum zur
Mangelernährung führen kann. Zunehmende Evidenzen belegen den
negativen Effekt der Mangelernährung auf Therapieerfolg,
Morbidität und Mortalität. Daher sind angemessene
ernährungstherapeutische Maßnahmen unabdingbar. Gezielte
Ernährungsinterventionen sollen der Ätiologie einer
Mangelernährung (wie z. B. Diarrhoe, Übelkeit und
Appetitlosigkeit) entgegenwirken und sollten patientenzentriert erfolgen. Hierzu
gehört auch die Beseitigung von Fehlinformation und die Vermittlung von
praktischen und einsetzbaren Empfehlungen.
Second-Look-Ultraschall mittels Scherwellen-Elastografie bei Verdacht auf lokoregionales Rezidiv des Mammakarzinoms im MRT
Authors: Divjak Eugen , Ivanac Gordana , Radović Niko , Špoljar Iva Biondić , Sović Slavica , Bahnik Valentina , Brkljačić Boris 
Published: September 2022

Zusammenfassung
Ziel Es soll untersucht werden, ob der Second-Look-US mittels Scherwellen-Elastografie (SWE) nützlich ist, um zwischen benignen und malignen Veränderungen in der postoperativen Brust nach der operativen Therapie des Mammakarzinoms zu differenzieren.
Material und Methoden SWE und die damit verbundenen sonografischen Merkmale wurden bei 90 Patientinnen mit Anamnese einer operativen Therapie des Mammakarzinoms und einer bei der MRT-Nachuntersuchung entdeckten verdächtigen Läsion überprüft. Ein einziger erfahrener Radiologe führte alle Second-Look-US-Untersuchungen mit SWE-Messungen durch, indem er eine kreisförmige Region of Interest von 2 mm Durchmesser über dem steifsten Teil der Läsion legte. Gewebeproben für die histopathologische Untersuchung wurden dabei durch Stanzbiopsie entnommen.
Ergebnisse Von 90 Läsionen erwiesen sich 39 als maligne in der histopathologischen Untersuchung. Von den malignen Läsionen zeigten 50 % Elmax-Werte im Bereich von 128 bis 199 kPa, und 50 % der benignen Läsionen hatten Elmax-Werte von 65 bis 169 kPa. Ein Cut-off-Wert von 171,2 kPa für Elmax zeigt eine Sensitivität von 59 % und eine Spezifität von 78,4 % für das Karzinomrezidiv und eine AUC von 0,706 (95 %-KI 0,6–0,81; p = 0,001). In univariaten logistischen Modellen erwiesen sich eingeschränkte Diffusion und Steifigkeit bei SWE, Elmax > 171,2 kPa, als signifikante Rezidiv-Prädiktoren. Im multivariaten Modell bleibt die eingeschränkte Diffusion ein signifikanter unabhängiger Rezidiv-Prädiktor. Bei einer Rezidiv-Prävalenz von 43 % liegt die Testsensitivität bei 95 % (95 %-KI 81–99 %) und die Spezifität bei 75 % (95 %-KI 60–85 %).
Schlussfolgerung Steifere Läsionen in der postoperativen Brust sollten im Second-Look-Ultraschall als suspekt angesehen werden. SWE kann eine hilfreiche Methode zur Identifizierung maligner Läsionen sein, insbesondere im Zusammenhang mit einer eingeschränkten Diffusion in der MRTUntersuchung. Die Steifigkeit der Läsion sollte jedoch nicht als unabhängiger Prädiktor für die Läsionsmalignität in der postoperativen Brust angesehen werden, da in der SWE benigne Veränderungen steif, Karzinomrezidive hingegen weich erscheinen können.
Luxação intraprotética precoce de artroplastia total do quadril com implante de dupla mobilidade: Relato de caso
Authors: Lima Thiago Lopes , Pallottino Alexandre de Bustamante , Franco José Sérgio , Chami Sávio Manhães , Scorza Breno Jorge , Morais Brunno Benedetti de 
Published: September 2022

ResumoA artroplastia total do quadril (ATQ) é uma cirurgia bem-sucedida no tratamento da dor no quadril, mas existem complicações potenciais, das quais a luxação é uma das mais comuns. O gerenciamento das luxações é um problema desafiador que requer uma abordagem multimodal, e o uso de implantes de mobilidade dupla é uma opção. Apresentamos uma paciente com história de fratura do colo do fêmur que foi submetida a ATQ com um implante de dupla mobilidade. No 18° dia pós-operatório, após queda ao solo, a paciente evoluiu com luxação da prótese e teve uma complicação após redução fechada, uma luxação intraprotética subsequente. Após um diagnóstico radiográfico, a paciente apresentou sinais mecânicos na flexão do quadril causados por um implante de mobilidade dupla desassociado. A cirurgia de revisão foi indicada, mas a paciente optou por não realizar o procedimento cirúrgico necessário. O estudo pós-operatório cuidadoso das radiografias revelou uma cabeça femoral excêntrica e evidências do implante desassociado nos tecidos moles circundantes. As radiografias após a redução fechada das luxações intraprotéticas devem ser examinadas minunciosamente.
The small-scale limits of electron beam melt additive manufactured Ti–6Al–4V octet-truss lattices
Authors: Neils Andrew , Dong Liang , Wadley Haydn 
Published: September 2022

The emergence of powder-based additive manufacturing (AM) processes, such as electron beam melting (EBM), enables the one step manufacture of microarchitected metamaterials from topology optimized models. However, many applications are optimized by low relative density lattices with slender trusses whose diameter approaches small multiples of largest powder particles, potentially resulting in surface roughness. The thermal history experienced by alloy powders also modifies the alloy microstructure, and thus mechanical behavior, posing a significant challenge to metallic metamaterial designs and fabrication. We therefore build and characterize the multiscale structure and mechanical properties of EBM manufactured Ti–6Al–4V octet truss lattices with strut diameters approaching the particle diameter-imposed fabrication limit. We measure the dependence of their relative density, elastic modulus, and compressive strength on the fabrication process-controlled truss topology and microstructure, and compare them to identical smooth surface structures made from an annealed, wrought version of the same alloy built using a snap-fit assembly method. Micro-x-ray tomography confirmed that the lattice strut surfaces were covered with partially melted powder particles, resulting in about 29% of the lattice mass that inefficiently supported the applied loads. The use of a powder bed held at a temperature of 600–700 °C also resulted in a lamellar α/β phase microstructure with an elastic modulus, yield strength, and a ductility that were less than the equiaxed α/β microstructure of snap-fit assembled structures. However, the higher tangent modulus of the lamellar AM processed alloy resulted in significant strengthening of EBM lattices that failed by inelastic buckling during compression. The ability to increase the alloy tangent modulus during an EBM build process therefore provides a promising approach for increasing lattice compressive strength and therefore compensates for surface roughness induced losses.
Slamsex in The Netherlands among men who have sex with men (MSM): use patterns, motives, and adverse effects
Authors: Knoops Leon , van Amsterdam Jan , Albers Thijs , Brunt Tibor Markus , van den Brink Wim 
Published: September 2022

Background This paper describes an online survey of men who have sex with men (MSM) and use drugs before or during sex (‘chemsex’) via injection (‘slamming’ or ‘practising slamsex’). Approximately 15–30% of the MSM population in The Netherlands have practiced chemsex at some point, and 0.5–3.1% of them ever had ‘slamsex’. This study investigates which substances are used in The Netherlands during slamsex, the motives for slamming and the health risks involved. Method In total, 175 MSM from The Netherlands, who had used substances before or during sex via injection completed an ad hoc online questionnaire designed for this study. Results Mean age of respondents was 47.8 years. During chemsex, almost every substance was used; the most common substances that were injected (slammed) were 3-methylmethcathinone (3-MMC), methamphetamine, ketamine, 4-methylethcathinone (4-MEC) and mephedrone (4-MMC). Reasons for slamming were mainly to experience a more intense rush and longer sex. Virtually none of the respondents used a condom during slamsex, but needles were almost never shared or used only once. Slammers reported health problems associated with injecting drugs (skin problems, collapsed veins and infections). Of most concern were the psychological symptoms reported by about three-quarters of respondents (e.g. insomnia, sadness, depressed mood, anxiety, suicidal tendencies). About half of respondents reported some degree of loss of control or concerns about their slamming behaviour. Conclusion Results show that slamsex is associated with consciously chosen sexual risk behaviours and risk-avoidance slam behaviours. This study may contribute to the reinforcement of accessible, non-judgmental and well informed prevention and harm reduction activities to support MSM practising slamsex.
Impacts of long-term rice-based organic farming on fractions and forms of soil organic carbon and nitrogen in the Indo-Gangetic Plain
Authors: Meena Amrit Lal , Pandey R. N. , Kumar Dinesh , Sharma V. K. , Meena M. D. , Karwal Minakshi , Dutta Debashis , Meena L. K. , Narwal Ekta , Mishra R. P. , Panwar A. S. , Ghosh A. 
Published: September 2022

The present study aimed to appraise the long-term effects of organics, crop residues, and biofertilisers on soil carbon (C) and nitrogen (N) pools for sustainable crop production and changes in soil quality under long-term organic farming practices. Hence, we studied the soil C and N pools and their sensitivity indices as influenced by a different combination of farmyard manure, vermicompost, biofertilisers, and crop residue of rice, wheat, and mungbean, under long-term rice–wheat–mungbean (RWMCS) and rice–wheat (RWCS) cropping systems in an Inceptisol of India. Total soil organic C increased by 78% and 104% for RWMCS and 94% and 123% for RWCS with FYM + crop residue + biofertilisers and vermicompost + crop residue + biofertilisers, respectively over unfertilised control plots of RWMCS. The highly labile C and microbial biomass C were highly sensitive to management practices compared to total organic C and less labile C fractions. Integrated application of manures and crop residues in FYM + crop residue and VC + crop residue resulted in significantly higher total N, labile N, and mineral N for both cropping systems. Higher values of C and N management indexes were observed with FYM + crop residue + biofertilisers and VC + crop residue + biofertiliser in both cropping systems than other treatments. Integrated use of organic sources had higher N fractions than the unfertilised control plots, indicating that long-term conjoint use of organics, crop residues, and biofertilisers could sustain crop production and soil quality.
From deontic modality to conditionality
Authors: Kuo Yueh Hsin 
Published: September 2022

AbstractWhile epistemic modality has been suggested to be a modal source of conditionality, deontic modality has been generally overlooked. Using data from Classical Chinese and the Invited Inferencing Theory of Semantic Change, this study demonstrates that the deontic modalbitends to invite inferences of conditionality in contexts where it is used teleologically and performatively as an indirect speech act of advice. That is, conditionality can emerge out of an interaction of teleological and performative meanings. Furthermore, three conditions are identified as where teleological, performative and conditional meanings enable the inferencing of the deontic modalbias a conditional protasis connective. The absence of one or more of these conditions is shown to be less likely to invite inferences of conditionality.