bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Impact of Early Treatment and Oxaliplatin Discontinuation in Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 11 Adjuvant Trials
Authors: Gallois Claire , Shi Qian , Meyers Jeffrey P. , Iveson Timothy , Alberts Steven R. , de Gramont Aimery , Sobrero Alberto F. , Haller Daniel G. , Oki Eiji , Shields Anthony Frank , Goldberg Richard M. , Kerr Rachel , Lonardi Sara , Yothers Greg , Kelly Caroline , Boukovinas Ioannis , Labianca Roberto , Sinicrope Frank A. , Souglakos Ioannis , Yoshino Takayuki , Meyerhardt Jeffrey A. , André Thierry , Papamichael Demetris , Taieb Julien 
Published: November 2022

PURPOSE Oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer (CC) for 6 months remains a standard in high-risk stage III patients. Data are lacking as to whether early discontinuation of all treatment (ETD) or early discontinuation of oxaliplatin (EOD) could worsen the prognosis. MATERIALS AND METHODS We studied the prognostic impact of ETD and EOD in patients with stage III CC from the ACCENT/IDEA databases, where patients were planned to receive 6 months of infusional fluorouracil, leucovorin, and oxaliplatin or capecitabine plus oxaliplatin. ETD was defined as discontinuation of treatment and EOD as discontinuation of oxaliplatin only before patients had received a maximum of 75% of planned cycles. Association between ETD/EOD and overall survival and disease-free survival (DFS) were assessed by Cox models adjusted for established prognostic factors. RESULTS Analysis of ETD and EOD included 10,447 (20.9% with ETD) and 7,243 (18.8% with EOD) patients, respectively. Compared with patients without ETD or EOD, patients with ETD or EOD were statistically more likely to be women, with Eastern Cooperative Oncology Group performance status ≥ 1, and for ETD, older with a lower body mass index. In multivariable analyses, ETD was associated with a decrease in disease-free survival and overall survival (hazard ratio [HR], 1.61, P < .001 and HR, 1.73, P < .001), which was not the case for EOD (HR, 1.07, P = .3 and HR, 1.13, P = .1). However, patients who received < 50% of the planned cycles of oxaliplatin had poorer outcomes. CONCLUSION In patients treated with 6 months of oxaliplatin-based chemotherapy for stage III CC, ETD was associated with poorer oncologic outcomes. However, this was not the case for EOD. These data favor discontinuing oxaliplatin while continuing fluoropyrimidine in individuals with significant neurotoxicity having received > 50% of the planned 6-month chemotherapy.
Approach to the Patient With a Suppressed TSH
Authors: Praw Stephanie Smooke , Brent Gregory A 
Published: November 2022

Abstract
Subclinical hyperthyroidism (SCH) is a laboratory diagnosis defined by a serum thyrotropin (TSH) concentration below the reference range (&lt; 0.4 mU/L in most assays), and a free thyroxine (FT4) and 3,5,3′-triiodothyronine levels (FT3) in the reference range. Many patients diagnosed with SCH will be clinically euthyroid while others may present with manifestations characteristic of thyroid hormone excess, such as tachycardia, tremor, intolerance to heat, bone density loss, or weight loss. In addition to the laboratory abnormalities, patient factors such as age, symptoms, and underlying heart and bone disease are used to stratify patients for the risk of adverse outcomes and determine the appropriate treatment. Evaluation should include repeat thyroid function tests to document persistent TSH suppression, investigation of the underlying cause, as well as evaluation of the patient's risk of adverse outcomes in the setting of a subnormal TSH. Persistent SCH has been associated with an increased risk of a range of adverse events, including cardiovascular events such as atrial fibrillation and heart failure, bone loss and fracture, and in some studies, cognitive decline. Despite the consistent association of these adverse events with SCH, prospective studies showing improved outcomes with treatment remain limited. Management options include observation without active therapy, radioactive iodine ablation of the thyroid, antithyroid medication, thyroid surgery, or radiofrequency ablation, as appropriate for the patient and clinical setting. The choice of therapy should be guided by the underlying etiology of disease, patient factors, and the risks and benefits of each treatment option.
Health-Related Quality of Life at Diagnosis for Pediatric Thyroid Cancer Patients
Authors: Perez Megan N , Halada Stephen , Isaza Amber , Sisko Lindsay , Mostoufi-Moab Sogol , Bauer Andrew J , Barakat Lamia P 
Published: November 2022

AbstractContextPediatric thyroid cancer (TC) incidence rates are increasing, yet TC has one of the highest survival rates. Despite increased prevalence, little is known about youth adjustment to TC, particularly compared to other pediatric cancers.ObjectiveThe current study sought to describe health-related quality of life (HRQoL) in pediatric TC patients early after diagnosis compared to other pediatric cancer patients and healthy youth and examine predictors of HRQoL.MethodsPediatric TC patients (ages 8.5–23.4 years) and their caregivers from a pediatric thyroid center completed psychosocial questionnaires as part of a clinic-based screening program around time of surgery. TC HRQoL was compared to other pediatric cancer and healthy youth reported norms. Clinical and demographic data extracted from the medical record were examined for predictors of HRQoL. The main outcome measures included the Pediatric Quality of Life Inventory (PedsQL) and Distress Thermometer.ResultsFindings evidenced significantly higher HRQoL for TC patients than other pediatric cancers for all but emotional and school functioning. Compared to healthy youth, TC patients reported significantly lower functioning, except comparable social functioning. No significant differences in HRQoL were identified based on disease severity, thyroid disease history, or treatment. Patient distress was associated with HRQoL.ConclusionThe findings suggest general resilience in TC patients compared to youth with other cancers, yet worse HRQoL than peers. Early universal screening is warranted due to a short TC treatment regimen. If administrative barriers preclude comprehensive screening, the single-item Distress Thermometer may identify patients for further comprehensive screening.
Another Country: Cuban Communism and Black Self-Determination, 1932–1936
Authors: Wood Tony 
Published: November 2022

AbstractBetween 1932 and 1935, the Cuban Communist Party (PCC) argued that the majority-Black population of Oriente, the island's easternmost province, should be granted the right to national self-determination. While this policy has often been dismissed as a passing aberration, I argue that Black self-determination in fact left a lasting imprint both on the PCC and on the country's political landscape. I draw on research in Cuban and Russian archives to show that, far from being imposed on local Communists by the Comintern, the policy was most clearly formulated by Cubans, including leading members of African descent. I further show that it served as the focal point for the development of the PCC's antiracist stance, which by the end of the decade had made it a leading proponent of equality. Self-determination was integral to that transformation, which reshaped the party's composition and social basis for years to come.
Opaque Infrastructure: Black Markets as Architectures of Care
Authors: Tayob Huda 
Published: November 2022

AbstractBellstat Junction and Sekko's Place are two markets in Cape Town established by migrants, refugees, and asylum seekers. They are perhaps better understood as black markets existing within a lineage of global black urbanisms, past and future. These sites occupy a slippery legality, sited in the peripheral margins and shadows of the central city of Cape Town. They operate across grammars of transaction and care. An architectural reading of black markets enables a drawing out and stitching together of the constituents of these sites: of site and story, of domesticity and infrastructure, of publicness and transnational networks. Adopting the term black markets for these sites calls attention to the racialization of these spaces, and their emergence as sites of possibility, precarity, and care in the face of protracted crises.
In Passing: Some Notes on Urban Life
Authors: Khanolkar Prasad 
Published: November 2022

AbstractThe expansionist mode of neoliberal urbanization relies on a subtractive logic that renders lives, habitats, and rhythms along its path as both expendable and profitable. This essay uses the conceptual lens of “passages” to read how urban entities, those rendered “expendable,” seep back in through different urban passages and “play” the game of urbanization. These passages are not given, but constellated by drawing disparate urban entities into a relationship. In them, urban entities, although deemed expendable, are in medias res and incomplete; they are the mediums in which life takes form; and they have the “abilities” to take on many forms. The essay thus departs from the demographic and territorial notions of “what is urban,” to explore the urban as a constitutive medium composed of numerous passages. It asks, What is at play in them? What life forms in passing? And how might we conceive of Walter Benjamin's Passagen-Werk down South?
Perylene-Templated Hierarchically Porous Carbon Fibers as Efficient Supercapacitor Electrode Material
Authors: Perez-Calm Adria , Shrestha Lok Kumar , Magana Jose Rodrigo , Esquena Jordi , Salonen Laura M , Shrestha Rekha Goswami , Ma Renzhi , Ariga Katsuhiko , Rodriguez-Abreu Carlos 
Published: November 2022

Abstract
Nitrogen-doped nanoporous carbon fibers were prepared using chromonic perylene bisimide self-assemblies as templates. The method involves the formation of perylene-templated silica followed by carbonization and etching. This strategy does not require any additional carbon or nitrogen precursor and therefore omits the associated impregnation step. The obtained carbon fibers were tested as electrode materials for supercapacitor applications. Owing to the high surface area (695 m2 g−1) and well-developed porosity (pore volume ca. 0.67 cm3 g−1) with hierarchical micro- and mesopore structures, N-doping and high-wettability, amorphous carbon fibers show excellent electrical double-layer capacitance with faradaic pseudocapacitance performance in an aqueous electrolyte solution (1 M H2SO4). A working electrode prepared from the optimal sample achieved a high specific capacitance of 317 F g−1 at a current density of 1 A g−1 with excellent capacitance retention of 80% at a high current density of 50 A g−1 suggesting a fast electrolyte ion diffusion at the electrode surface. The electrode also showed outstanding cycle stability of 99% after 10,000 successive charge-discharge cycles. These results show the high potential of chromonic-derived hierarchically porous carbon fibers as electrode materials for high-performance supercapacitors with advantages over electrospinning and catalytic fabrication methods, such as the absence of heavy metals and organic solvents in the preparation procedure.
What is the association between common medications (indomethacin, ibuprofen and acetaminophen) and spontaneous intestinal perforations in premature infants? A systematic review protocol
Authors: Hudson Jo-Anna , Shabbir Wardha , Chan Monica Lik Man , Hayawi Lamia , Barrowman Nicholas , Sikora Lindsey , Ferretti Emanuela 
Published: November 2022

Background: Spontaneous intestinal perforation (SIP) affects very low birth weight preterm neonates and accounts for 44% of gastrointestinal perforations. Commonly used medications such as indomethacin, ibuprofen and acetaminophen for PDA closure, increases the risk of intestinal perforation. Unfortunately, the majority of the data combine SIP with those affected by necrotizing enterocolitis (NEC) despite them being separate entities. This systematic review aims to explore the association between the use of common medications and SIP in the premature infant cohort independently from NEC. Methods: Our study will focus on preterm infants with exposure to either indomethacin, ibuprofen or acetaminophen where SIP is a reported outcome. A health science librarian will search Medline and Medline in Process via OVID, Embase Classic + Embase via OVID, the LILACS database, the ScIELO database and the Cochrane Library including EBM Reviews - Cochrane Central Register of Controlled Trials. Search dates for each database will be from their respective dates of inception to March 2022. All articles will undergo screening by two independent reviewers, and if selected, data extraction with risk of bias assessment by two independent reviewers. A third reviewer will settle any disagreements that may occur. Incidence of SIP will be measured as a proportion. Individual proportions will be pooled using a random effects logistic regression model. The comparative incidence of SIP by treatment group will be measured using the odds ratio. Odds ratios will be pooled using the DerSimonian and Laird random effects model for meta-analysis. PROSPERO Registration: CRD42017058603
The number of neutral mutants in an expanding Luria-Delbrück population is approximately Fréchet
Authors: Frank Steven A. 
Published: November 2022

Background: A growing population of cells accumulates mutations. A single mutation early in the growth process carries forward to all descendant cells, causing the final population to have a lot of mutant cells. When the first mutation happens later in growth, the final population typically has fewer mutants. The number of mutant cells in the final population follows the Luria-Delbrück distribution. The mathematical form of the distribution is known only from its probability generating function. For larger populations of cells, one typically uses computer simulations to estimate the distribution. Methods: This article searches for a simple approximation of the Luria-Delbrück distribution, with an explicit mathematical form that can be used easily in calculations. Results: The Fréchet distribution provides a good approximation for the Luria-Delbrück distribution for neutral mutations, which do not cause a growth rate change relative to the original cells. Conclusions: The Fréchet distribution apparently provides a good match through its description of extreme value problems for multiplicative processes such as exponential growth.
Digital infrared chromatic aberration correction algorithm for a membrane diffractive lens based on coherent imaging
Authors: Wu Jiang , Li Daojing , Cui Anjing , Gao Jinghan , Zhou Kai , Liu Bo 
Published: November 2022

Aiming at the wide-spectrum chromatic aberration problem of membrane diffractive
lenses, the concept of the digital chromatic aberration correction
infrared imaging system was proposed. The principle of digital
chromatic aberration correction was given, and the chromatic
aberration correction of this system was completed on a computer,
which is based on a wavelength-tunable laser local oscillator coherent
detection detector. Compared with the chromatic aberration correction
method for traditional lenses, this membrane diffractive optical
system exhibited characteristics of small size, low weight, and low
complexity. The digital chromatic aberration correction application
conditions of this membrane diffractive optical system were analyzed.
In addition, the main parameters and imaging simulation results were
given. The center wavelength of this membrane diffractive optical
system is 1.55 µm, and its spectral range is
1.50–1.60 µm. The application of autocorrelation processing to
infrared complex images after digital chromatic aberration correction
followed by incoherent accumulation of the received corrected complex
images based on multiple stepping wavelengths could significantly
improve the imaging signal-to-noise ratio.
Magnification and quality improvement for an optical cylindrical holographic display
Authors: Wang Jun , Guo Zicheng , Wu Yang 
Published: November 2022

Cylindrical holograms have been widely studied for their 360° display properties and have remained in the theoretical stage for a long time because of the difficulty to manufacture cylindrical spatial light modulators (SLMs). Recently, an optical realization of cylindrical holography using a planar SLM that converts planar holography into cylindrical holography through a conical mirror has been proposed. However, the magnification and quality improvement of the reconstruction have remained issues from the original method that still must be addressed. In this paper, a Fourier hologram optimization with stochastic gradient descent (FHO-SGD) is proposed for the magnification and quality improvement of an optical cylindrical holographic display. The reconstructed object is magnified 2.9 times by a lens with a focal length of 300 mm due to the optical properties of Fourier holograms. In addition, the quality of the reconstructed objects is significantly improved. Numerical simulation and optical experiments demonstrate the effectiveness of the proposed FHO-SGD method in the magnification and quality improvement of an optical cylindrical holographic display.
Identities of women who have an autoimmune rheumatic disease [ARD] during pregnancy planning, pregnancy and early parenting: A qualitative study
Authors: Williams Denitza , Pell Bethan , Grant Aimee , Sanders Julia , Taylor Ann , Edwards Adrian , Choy Ernest , Phillips Rhiannon 
Published: November 2022

Objective
Women of reproductive age who have autoimmune rheumatic diseases [ARDs] have expressed a need to be better supported with making decisions about pregnancy. Women with ARDs want their motherhood identities and associated preferences to be taken into account in decisions about their healthcare. The aim of this study was to explore the interplay between illness and motherhood identities of women with ARDs during preconception decision making.

Methods
Timeline-facilitated qualitative interviews with women diagnosed with an ARD [18–49 years old]. Participants were purposively sampled based on the following three criteria: thinking about getting pregnant, currently pregnant, or had young children. Interviews were thematically analysed.

Results
Twenty-two women were interviewed face-to-face [N = 6] or over the telephone [N = 16]. Interview length ranged from 20 minutes to 70 minutes, with a mean length of 48 minutes. Three main themes were identified: prioritisation, discrepancy, and trade-off. Difficulties in balancing multiple identities in healthcare encounters were reported. Women used ‘self-guides’ as a reference for priority setting in a dynamic process that shifted as their level of disease activity altered and as their motherhood identity became more or less of a focus at a given point in time. Women’s illness and motherhood identities did not present in isolation but were intertwined.

Conclusions
Findings highlight the need for holistic person-centred care that supports women with the complex and emotive decisions relating to preconception decision-making. In practice, health professionals need to consider women’s multiple and sometimes conflicting identities, and include both their condition and family associated goals and values within healthcare communication.
Mesenchymal stromal cell therapy compared to SGLT2-inhibitors and usual care in treating diabetic kidney disease: A cost-effectiveness analysis
Authors: Barry Luke E. , Crealey Grainne E. , Cockwell Paul , Elliman Stephen J. , Griffin Matthew D. , Maxwell Alexander P. , O’Brien Timothy , Perico Norberto , O’Neill Ciaran 
Published: November 2022

Background and objectives
To simulate the cost-effectiveness of Mesenchymal Stromal Cell (MSC) therapy compared to sodium/glucose co-transporter 2 inhibitors (SGLT2i) or usual care (UC) in treating patients with Diabetic Kidney Disease (DKD).

Design, setting, participants, and measurements
This Markov-chain Monte Carlo model adopted a societal perspective and simulated 10,000 patients with DKD eligible for MSC therapy alongside UC using a lifetime horizon. This cohort was compared with an SGLT2i alongside UC arm and a UC only arm. Model input data were extracted from the literature. A threshold of $47,000 per quality-adjusted life year and a discount rate of 3% were used. The primary outcome measure was incremental net monetary benefit (INMB). Sensitivity analysis was conducted to examine: parameter uncertainty; threshold effects regarding MSC effectiveness and cost; and INMB according to patient age (71 vs 40 years), sex, and jurisdiction (UK, Italy and Ireland).

Results
While MSC was more cost-effective than UC, both the UC and MSC arms were dominated by SLGT2i. Relative to SGLT2i, the INMB’s for MSC and UC were -$4,158 and -$10,085 respectively indicating that SGLT2i, MSC and UC had a 64%, 34% and 1% probability of being cost-effective at the given threshold, respectively. This pattern was consistent across most scenarios; driven by the relatively low cost of SGLT2i and demonstrated class-effect in delaying kidney failure and all-cause mortality. When examining younger patients at baseline, SGLT2i was still the most cost-effective but MSC performed better against UC given the increased lifetime benefit from delaying progression to ESRD.

Conclusions
The evidence base regarding the effectiveness of MSC therapy continues to evolve. The potential for these therapies to reverse kidney damage would see large improvements in their cost-effectiveness as would targeting such therapies at younger patients and/or those for whom SGLT2i is contra-indicated.
Impact of body and orofacial appearance on life satisfaction among Brazilian adults
Authors: Campos Lucas Arrais , Campos Juliana Alvares Duarte Bonini , Silva Wanderson Roberto da , Peltomäki Timo , Pinto Ary dos Santos , Marôco João 
Published: November 2022

Aims
1. to elaborate a general model of physical appearance taking into account body image (BI) and orofacial appearance (OA) components; and 2. to evaluate the impact of BI and OA on life satisfaction among Brazilian adults.

Methods
This is a cross-sectional observational study. The cognitive, behavioral, affective, and satisfaction/dissatisfaction aspects of BI, the satisfaction and psychosocial impact of OA, and life satisfaction were evaluated by self-reported psychometric scales. Principal Component Analysis and Parallel Analysis were performed. Structural equation models were elaborated to estimate the impact of BI and OA on life satisfaction. The fit of the models was verified and the significance of the path estimates (β) was evaluated using z-tests (α = 5%).

Results
A total of 1,940 individuals participated in the study (age: mean = 24.8, standard deviation = 5.7 years; females = 70.1%). In the male sample, three physical appearance factors were retained (OA, cognitive and behavioral components of BI, and affective and satisfaction/dissatisfaction components of BI). In the female sample, two factors were retained (OA and all components of BI). All factors had significant impact on life satisfaction (β = |0.26|-|0.48|, p<0.001) in both samples. Individuals dissatisfied with BI and OA had lower levels of life satisfaction. For men, the affective and satisfaction components of BI had a greater impact on life satisfaction (β = 0.48, p<0.001) than the other factors (β =] -0.30;-0.25[, p<0.001). For women, both BI and OA had a similar impact (BI: β = -0.30, p<0.001; OA: β = -0.32, p<0.001).

Conclusion
BI and OA formed distinct clusters in the physical appearance evaluation. Physical appearance was perceived differently by men and women, fostering discussion about the sociocultural construction of the body. BI and OA had a significant impact on life satisfaction and should be considered in assessment and treatment protocols.