bluuebunny/crossref_metadata_2025_split huggingface dataset:
Receiver operating characteristic analysis to determine optimal cutting point of cage in predicting physical and mental comorbidities among alcohol users
Authors: Chu C.Y. , Wang S.C. , Lee C.H. , Cheng C.M. 
Published: February 2022

IntroductionAlcohol use disorder (AUD) is highly related to various comorbidities, such as cancer, cognitive impairment, cirrhosis, chronic sclerosing stomatitis, stroke, and depression. The CAGE (Cut down, Annoyed, Guilty, Eye-opener) questionnaire is a simple screening material to make a diagnosis of alcoholism.ObjectivesOur study aimed to find an optimal cut-off point of CAGE for alcohol-related comorbidities in Taiwan.MethodsWe performed demographic analysis for 280 participants with AUD and categorized them into two groups according to CAGE scores. We applied receiver operator characteristic (ROC) analysis to determine optimal cutting point of CAGE in predicting physical and mental problems among alcohol users. Statistical analysis was performed with the Statistical Software Stata version 12.0 (StataCorp LP, College Station, TX, USA).ResultsThe mean age of participants was 45.9 ± 10.5 years, and all of them were male. Among 280 participants, 134 (47.9%) had physical diseases, including 37 (13.2%) with liver disease, 10 (3.6%) with pancreatitis, 22 (7.9%) with gout, and 5 (1.8%) with esophageal varices; while 33 (11.8%) had one or more mental illnesses. Patients with CAGE score greater than 3 were more likely to have both mental health problems and/or physical diseases, especially hepatic disease and esophageal varices.ConclusionsThis study revealed that with CAGE score greater than 3, male patients with AUD are at higher risks of both physical and mental comorbidities. Further research as well as female participants are needed to identify the associations between the severity of alcohol use disorder and related diseases for comprehensive evaluation in Taiwan.
Clinical and therapeutic aspects of the alcohol addiction phenomenon in elderly women
Authors: Sosin I. , Mysko G. , Honcharova O. , Misna O. , Minko O. 
Published: February 2022

IntroductionAge-related features of alcohol addiction in elderly women (AAEW) have not been studied properly. The WHO classifies 60-75 years as elderly age (‘early old age’), when morphological and physiological functions of all organs and systems fade away, causing severe post-intoxication and withdrawal disorders, giving organic tint to alcohol dependence clinical picture, and rapid onset of alcoholic mental degradation of personality.ObjectivesTo study specific clinical, diagnostic and pathophysiological basis of alcohol dependence in aged women for innovative approaches to AAEW treatment.MethodsClinical and medical history questioning, international tests and scales to identify alcohol dependence and complications in elderly women. Follow-up monitoring of basic biochemical, clinical, laboratory and electrophysiological findings at treatment runtime.ResultsMultifactorial study and specific gender features in AAEW development allowed to identify abundant dual comorbidity, prevalence, high degree of affective disorders (depression, anxiety, dysphoria) combined with various somatic conditions and diencephalic symptoms in this alcoholic disease pattern. New treatment modality for alcohol dependence in elderly women was proposed and tested; along with classical detoxification and symptomatic therapy, the patients received anxiolytic agent (serotonin receptor stimulator) Buspirone SANDOZ, 5 mg 3 times a day, followed by individually corrected effective dose. The drug stopped anxiety, balanced the mood, causing no addiction. Buspirone was combined with bromine and sodium sulfate transcerebral electrophoresis № 5 and selective psychotherapy.ConclusionsThe proposed integrated therapy for AAEW was proven to be effective by statistical reliability and patient-specific clinical illustrations.
Mental health and human rights of women
Authors: Amering M. 
Published: February 2022

IntroductionMental health stigma and discrimination interact with gender inequality and the discrimination of women and girls to their mental health detriment.ObjectivesPresent and discuss the challenges and opportunities of a human rights based approach to womens’ mental health.MethodsNon-systematic review of policy and practice of human rights based interventions for womens’ mental health.ResultsCurrent mental health as well as gender equality legislation converge towards the realization of longstanding demands of equality for women as well as for persons with mental health problems: removal of barriers, respect and enablement of autonomy, renewed efforts toward effective inclusion in all spheres of life. Essential changes through non-discrimination laws concern key areas, including family planning, marriage and parenthood, employment, housing, education, health, standards of living and social, political and cultural participation, along with the right to be free from exploitation, violence and abuse. Because of the cumulation and the interaction of gender-based and other forms of discrimination, legislations such as the UN-Convention on the Rights of Persons with Disabilities (UN-CRPD) include a focus on gender-specific human rights needs of women and girls. Family advocacy in mental health is prominently supported by female activists as is the user movement.ConclusionsThe opportunities of a successful development towards non-discrimination and gender equality in mental health care are dependent on a viable understanding of these concepts within the mental health community as well as updated expertise concerning tools for implementation of support systems sensitive to the human rights needs of women and girls.DisclosureNo significant relationships.
Method of relieving hypertoxic alcohol abuse states in alcohol dependence
Authors: Sosin I. , Babenko Y. , Sergienko O. , Honcharova O. , Mysko G. , Lisova I. 
Published: February 2022

IntroductionCurrently, alcohol dependence is characterized by immediate onset of dipsomania states (code F10.26, ICD-10) interpreted in clinical addictology as reliable diagnostic signs of morbid alcohol dependence. These are classified clinically by rate, severity, therapeutically resistant post alcohol comorbidities (alcohol-induced polyneuropathy, hepatic dysfunctions, etc.), and by the presence of “lucid spaces”, when patients, depleted physically and mentally by hypertoxic alcohol abuse states, periodically (after binge drinking) intake no alcohol.ObjectivesEffectiveness improvement and reducing time of treatment for hypertoxic alcohol abuse states by reasonable pathogenetic use of highly effective drugs, wide polymodality and synergistic pharmacological range, with few side effects, potential for inclusion to the conventional standard treatment patterns according to thiamine concepts.MethodsValid clinical-diagnostic, laboratory, biochemical, electrophysiological, psychological (scaling, testing), statistical methods for identification of alcohol dependence complicated by hypertoxic alcohol abuse states.ResultsA new method of alleviating the hypertoxic intoxication in alcohol dependence has been developed on representative clinical material, which involves conventional pharmacological and drug-free symptomatic remedies and methods. Along with psychotherapeutic potentiation, a therapeutically targeted pharmacological complex was prescribed: intramuscular Vitaxon № 10 per course; Sibazon 0.5% solution, 2 ml intramuscular, 3-5 injections per course; oral Phenazepam, one tablet (0.001g) twice a day for 10-14 days; Cocarnit one ampoule daily intramuscular injection, for a course of 3-10 injections.ConclusionsThe effectiveness of the proposed pharmacological complex has been proven by the statistical reliability method and illustrated by clinical examples of patient-specific research.
Quality of life of alcohol dependence patients who have been having acute psychotic disorder
Authors: Kuzminov V. 
Published: February 2022

IntroductionSevere acute psychosis significantly alters patient’s quality of life in patients with alcohol dependence. The aim of the investigation were examination value quality of the life patients with alcohol dependence who have recently suffered of acute psychotic disorder. The factor influencing the quality of life is the psychoorganic syndrome after acute psychosis.Objectives120 patients with alcohol dependence who had recent history of acute psychosis were examined.MethodsPsychopathological.ResultsThe psychorganic syndromes at these patients were investigated. The Index quality of the life in these patients was assessed due to type of the psychorganic syndromes. The dynamics of the Index quality of the life at patients with psychorganic syndrome during the treatment were described. The subjective assessment of their condition in patients with hard psychorganic syndrome was dissociated from the assessment of doctors and relatives. The explaining the characteristics of the consequences of the transferred psychotic disorder to the patients turned out to be important for overcoming anosognosia. The Index quality of the life in these patients was assessed repeatedly at the same time, there was a significant decrease in the difference in the assessment of the quality of life by patients with relatives.ConclusionsThe importance of value quality of the life from the point of the patient, relatives of the patient and physician was underlined. The assesment of Index quality of the life is important important to explain the peculiarities of the postpsychotic state to the patients and their relatives in order to develop rehabilitation programs and carrying out psychotherapeutic activities.
The socio-professional impact of workaholism on engineers
Authors: Hrairi A. , Dhouib F. , Masmoudi R. , Kotti N. , Hammami K. Jmal , Masmoudi M. Larbi , Masmoudi J. , Hajjeji M. 
Published: February 2022

IntroductionWorkaholism is an “irrational commitment to excessive work” as described by Cherrington. It’s considered as an emerging phenomenon that has been the topic of much debate. Indeed, over the last four decades, many contradictions have arisen among researchers investigating its negative consequences.Objectives-Determine the prevalence of workaholism among a population of engineers. -Evaluate the socio-professional impact of workaholism on this population.MethodsThis study is a descriptive-cross sectional analysis conducted on active engineers for one month. Data were collected through an online questionnaire, including socio-professional data and the WART (Work Addiction Risk Test) questionnaire.ResultsOur population consisted of 75 engineers with an average age of 29± 4.6 years and sex-ratio of 1.2. Among this group, 26.7% of engineers were at risk of work addiction, while a certain addiction was noted among the third of the population. Workaholism was positively correlated with the lack of entertainment, especially sports activity (p= 0.012). Moreover, workaholic subjects were more likely to work more than 8 hours a day (p=0.004) and without a weekly break (p=0.043). Workaholism was not associated with the level of job satisfaction.ConclusionsWorkaholism is an emerging phenomenon among engineers that can lead, in some cases, to depression and burnout. Therefore, the role of the occupational physician consists in the detection of early signs of workaholism and in raising awareness of this hidden problem.Conflict of interestNo significant relationships.
Patient’s perspective on early treatment retention in take home buprenorphine maintenance treatment- an explorative study from India
Authors: M P. , Chand P. , Murthy P. 
Published: February 2022

IntroductionCurrently, Buprenorphine maintenance therapy (BMT) is an evidence-based treatment in retaining patients who are dependent on opioids. However, factors influencing retention are often measured objectively. Studies on patient’s perspectives on take home BMT in developing countries are limited.ObjectivesThis study examines the potential factors influencing treatment compliance in the early phase of Buprenorphine maintenance treatment from the patient’s perspectiveMethodsParticipants (n=89) who were initiated on BMT were recruited and followed after six weeks. A semi-structured interview was conducted with 62 patients who remained in treatment and 24 patients who dropped out of the studyResultsBased on the semi qualitative analysis some of the factors which facilitated the patient’s retention in treatment were: (1) Effectiveness in blocking withdrawal symptoms (2) effectiveness in reducing their cravings and controlling their opioid use (3) decreased fear of withdrawal and/or missing doses(4) improvement in the quality of life(5) patient-related factors like family support (6) effectiveness of the treatment program. Around nine percent of patients reported family support as the reason for retention, which is not noticed in other studies. Barriers reported by the patients while on medication were: (1) negative effect experienced with medication (2) program related difficulties like distance, unavailability (3) major life event interrupting the treatment (4) patient-related factors like low mood, financial constraints.ConclusionsUnderstanding factors associated with barriers to treatment provide insights into preventable factors that contribute to premature drop out from BMT and to improve clinical practice, policy decisions, or future research.
Smoking among patients followed at the department of psychiatry
Authors: Kerkeni A. , Abbes W. , Abbes M. , Medhaffer K. , Zitoun K. , Ghanmi L. 
Published: February 2022

IntroductionSmoking and nicotine dependence are particularly common in patients with a psychiatric disorder compared to the general population.ObjectivesTo study the prevalence of smoking in patients followed at the department of psychiatry and to assess their dependence on nicotine.MethodsThis was a cross-sectional, descriptive and analytical study. The study focused on patients followed at the department of psychiatry of the regional hospital of Gabes. Sociodemographic and clinical data were assessed. Fagerstrom questionnaire in its validated French version was used to assess the nicotine dependence. Data were analyzed using the software SPSS (20th edition).Results100 patients were included. They were male (60%) and single (50%) and with a mean age of 45.3 years [18-71]. The three most common pathologies were anxiety disorders (31%), schizophrenia (30%) and depression (29%). Among the patients surveyed 48% were smokers. Of which, 93.7% smoked cigarettes, 20.8% snorted chewing tobacco and 12.5% smoked hookah. The average number of pack-years was 11.6, with an average of 22.8 cigarettes per day. The mean duration of regular smoking was 19.1 years. Regarding nicotine dependence, 42% of patients were dependent. Regarding the degree of dependency, 43.7% were heavily dependent, 25% were weakly dependent and 18.8% were moderately dependent. Smoking was significantly associated with the male gender (p≤10-3), alcoholism (p=0.002) and schizophrenia (p=0.006).ConclusionsResults of our study show that smoking is frequent in patients followed at the psychiatry department. This aspect should be taken into account during the psychiatric evaluation, especially when therapeutic resistance occurs.
Mc Donalds’ model of deliverance of opioid substitution treatment in COVID-19 crisis in opioid belt in rural India : A retrospective - comparative study
Authors: Uppal G. 
Published: February 2022

IntroductionCOVID-19 has been declared as a pandemic by the World Health Organization on March, 2020. Opioid substitution therapy (OST) for opioid-dependent patients is an evidence-based, effective outpatient (OPD) based treatment maintained on medications(, buprenorphine-naloxone combination). These are difficult times for patients with addictive disorders. Authors came up with an idea of implementing “walk through” out patient model inspired by “Drive through” model of Mc Donalds in which Doctor and Nurses run open space OPD near to Medical record section to reduce the waiting time of patient, quick delivery and minimize droplet exposure.ObjectivesTo study the efficacy of Mc Donald’s model of OST in OST centre in Tarn Taran, india.MethodsThis was a restrospective-comparative study. We studied records of our patients using streatment as usual from September 2019 to March 2020 and using Mc Donald’s model (From April 2020 to October, 2020) for a period of 6 months during and before lockdown.ResultsThe average number of patients attending OST clinics during Covid lockdown was 352.8. The compliance rates significantly improved (57.82%), The drop out rates were much lower (20.78%), using Mc Donald’s model than usual treatment.ConclusionsAs per our knowledge, this study is first of its kind to study the efficacy of OST drug deliverance in pre Covid and Covid times and suggest, the new findings which can be inculcated in the other OSTs.
Treating addiction with psychedelics - are we waking up?
Authors: Miranda J. , Barbosa M. , Figueiredo I. , Mota P. , Tarelho A. 
Published: February 2022

IntroductionClassic psychedelics have been administered in sacramental contexts since ancient times. They were of prominent interest within psychiatry and neuroscience in the 1950s to 1960s, but the association between classic psychedelics and the emerging counterculture put an end to their research. Modern research with classic psychedelics has reinitiated interest in the treatment of both cancer-related distress and addiction, with really promising results.ObjectivesWe aim to provide a review about history and new insights regarding research with psychedelics specially as treatment of addictive disorders.MethodsA framing analysis of articles, searched on Pubmed (articles between 2010-2020) with the key words: “ psychedelics”, “psilocybin”, “substance use disorder”, “addiction”.ResultsClassic psychedelics are 5HT2AR agonists such as LSD, mescaline, and psilocybin. They were shown to occasion mystical experiences, which are experiences reported throughout different cultures and religions involving a strong sense of unity. These experiences are scientifically important because they appear to cause abrupt and sustained changes in behavior and perception, that can be very useful in the substance use disorder field. From this analysis is possible to understand that the use of psychadelics in the treatment of some addictions is currently at an early stage of research. However, they show interesting results with no clinically significant adverse events when risk individuals are excluded.ConclusionsIn comparison to psychedelic research about cancer-related psychological distress, studies with addictions are less developed, but if they continue to suggest safety and efficacy, may be the use of psilocybin for the treatment of specific addiction can happen in a close future.
Relationship between online cognition and personality traits: A questionnaire based study of medical college students
Authors: Ohri N. , Gill A. , Vankar G. , Tyagi P. , Reddy S. 
Published: February 2022

IntroductionCurrent classification systems are not sure where to place the internet use disorder. Is it an addiction, an impulse control disorder, a consequence of another psychiatric morbidity or a consequence of personality trait/personality disorder?ObjectivesWe intended to study which personality traits associated with online cognition may contribute towards Problematic internet use(PIU). We also analysed the relationship between number of hours of use/week of internet and PIU along with its relation with two ‘screening’ questions.MethodsOnline cognition scale and Abbreviated Eysenck Personality questionnaires were our measurements of choice in addition to demographic measures and some questions pertaining to online behaviour patterns.ResultsTotal 163 responses were analysed. The demographic pools consisted mostly of young adults who had, on average, used the internet for 5.2 years at present rate of 21.81hours/week. We observed significantly higher mean OCS scores in men, in people who thought that the internet interfered with their lives and in those who felt the need to ‘cut-down’. A moderate positive and significant correlation was observed between hpurs/week of internet use and OCS scores. Also, significant positive correlation was observed between Neuroticism and OCS, impulsivity, and loneliness/depression scores. Significant negative correlations were observed between the Lie trait and impulse control. Neuroticism and Lie together contributed to 21.8% of variance in OCS scores.ConclusionsNeuroticism and Lie traits (representing need for social acceptance) were found to the causing significamn varience in the OCS scores of the subjects. High number of hours/week use of internet was related to the feeling of ‘need to cut down use’.
Pornography cyberaddiction and impulsivity among medical tunisian students
Authors: Meseddi N. , Bouhamed M. , Bouattour O. , Chamseddine A. , Charfeddine F. , Aribi L. , Aloulou J. 
Published: February 2022

IntroductionMedical studies have always been considered as very stressful. Although these students are generally among the most academically successful students, they are not spared from developing both substance and behavioral addictions, particularly pornography cyberaddiction.ObjectivesTo evaluate the pornography cyberaddiction in a group of tunisian students, to study their impulsivity and determinate the link between these two entities.MethodsA descriptive and analytical cross-sectional study including 155 medical students. We used the S-IAT sex : to evaluate pornography cyberaddiction and Barrat bis 10 : to evaluate impulsivity.ResultsThe average age of students was 25.8 ±3.5 years old. The sex ratio (M/W) was 0,72. This medical students were single in 76.8%, had a high socio-economic status in 99.4% of case. They had a personal psychiatric history in 15.0%. They are smokers in 20%, consume alcohol in 30.3% and cannabis in 9% of case. The mean score of : the BIS 10 was 63.3 and the S-IAT was 15.6. The viewing of pornographic movies started around the age of 15 years old. Pornographic sites are the most frequently used tool (58.2%). The factors correlated with this addiction are: male sex (p=0.014), tobacco consumption (p=0.012), alcohol consumption (p=0.02) and impulsivity (p=0.03).ConclusionsIt resort from our study that medical students may suffer from pornography cyberaddiction. This increased use may be associated with impulsivity and substance use. Psychological support aimed specifically should be used to protect medical students.