bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of time‐to‐intravenous furosemide with mortality in acute heart failure: data from REPORT‐HF
Authors: Ouwerkerk Wouter , Tromp Jasper , Cleland John G.F. , Angermann Christiane E. , Dahlstrom Ulf , Ertl Georg , Hassanein Mahmoud , Perrone Sergio V. , Ghadanfar Mathieu , Schweizer Anja , Obergfell Achim , Dickstein Kenneth , Filippatos Gerasimos , Collins Sean P. , Lam Carolyn S.P. 
Published: October 2022

AbstractAimAcute heart failure can be a life‐threatening medical condition. Delaying administration of intravenous furosemide (time‐to‐diuretics) has been postulated to increase mortality, but prior reports have been inconclusive. We aimed to evaluate the association between time‐to‐diuretics and mortality in the international REPORT‐HF registry.Methods and resultsWe assessed the association of time‐to‐diuretics within the first 24 h with in‐hospital and 30‐day post‐discharge mortality in 15 078 patients from seven world regions in the REPORT‐HF registry. We further tested for effect modification by baseline mortality risk (ADHERE risk score), left ventricular ejection fraction (LVEF) and region. The median time‐to‐diuretics was 67 (25th–75th percentiles 17–190) min. Women, patients with more signs and symptoms of heart failure, and patients from Eastern Europe or Southeast Asia had shorter time‐to‐diuretics. There was no significant association between time‐to‐diuretics and in‐hospital mortality (p > 0.1). The 30‐day mortality risk increased linearly with longer time‐to‐diuretics (administered between hospital arrival and 8 h post‐hospital arrival) (p = 0.016). This increase was more significant in patients with a higher ADHERE risk score (pinteraction = 0.008), and not modified by LVEF or geographic region (pinteraction > 0.1 for both).ConclusionIn REPORT‐HF, longer time‐to‐diuretics was not associated with higher in‐hospital mortality. However, we did found an association with increased 30‐day mortality, particularly in high‐risk patients, and irrespective of LVEF or geographic region.Clinical Trial Registration: ClinicalTrials.gov Identifier NCT02595814.
Intensity measures, fragility analysis and dimensionality reduction of rocking under far‐field ground motions
Authors: Sieber Max , Vassiliou Michalis F. , Anastasopoulos Ioannis 
Published: October 2022

AbstractProblems for which it is impossible to make a precise causal prediction are commonly tackled with statistical analysis. Although fairly simple, the problem of a rocking block on a rigid base subjected to seismic excitation exhibits a fascinating, complex response, making it extremely difficult to validate numerical models against experimental results, thus calling for a statistical approach. In this context, this paper statistically studies the rocking behaviour of rigid blocks, excited by synthetic far‐field ground motions. A total of 50 million analyses are performed, considering rocking blocks of height ranging from 1 to 20 m and slenderness angle ranging from 0.1 to 0.35 rad. The results are used to explore the performance of different ground motion intensity measures (IMs), in terms of their ability to predict the maximum rocking rotation. By comparing the efficiency, sufficiency and proficiency of the IMs, it is found that the peak ground velocity (PGV) performs optimally. Then, fragility curves are constructed using different IMs, concluding again that the PGV is the most efficient IM. Impressively, the fragility curves for different block sizes collapse to a single curve, if a non‐dimensional IM that involves PGV and the block geometry is used. Finally, the results produced on the basis of far‐field synthetic motions are compared to results based on recorded ground motions.
Differences in rice yield and biomass accumulation dynamics for different direct seeding methods after wheat straw return
Authors: Tian Jinyu , Li Shaoping , Xing Zhipeng , Cheng Shuang , Guo Baowei , Hu Yajie , Wei Haiyan , Gao Hui , Liao Ping , Wei Huanhe , Zhang Hongcheng 
Published: October 2022

AbstractField experiments were performed in 2019 and 2020 to explore yield performance and biomass accumulation dynamics for different direct‐seeded rice methods after wheat straw return. The experimental treatments included two direct‐seeded rice methods (dry direct‐seeded rice and wet direct‐seeded rice) and two wheat straw return treatments (with and without wheat straw return). Wheat straw return had a negative impact on the yield and biomass of direct‐seeded rice. Compared with wet direct‐seeded rice, dry direct‐seeded rice was more negatively affected, with yield and biomass reduced by 6.7%–7.6% and 5.4%–6.5%, respectively. The yield loss was mainly associated with insufficient total spikelet numbers caused by reduced panicle numbers. A lower maximum tiller number caused by the restricted seedling tillering capacity was partly responsible for the inadequate panicle numbers in direct‐seeded rice after wheat straw return. Wheat straw return reduced the maximum and average rate of biomass accumulation, shortened the duration of effective biomass accumulation, and delayed the days to achieve the maximum rate of biomass accumulation for direct‐seeded rice. The negative effect of wheat straw return on direct‐seeded rice was concentrated mainly in the early stage; reduction in the average biomass accumulation rate in the early stage accounted for 61.1%–75.3% of the reduction in total average rate. Wet direct‐seeded rice had a higher average rate and amount of biomass accumulation at the early stage, a greater maximum tiller number, as well as a stronger photosynthetic ability and grain filling ability after heading, which contributed to improving panicle number and total spikelet number, ultimately increasing yield and biomass compared with dry direct‐seeded rice. These results demonstrate that wheat straw return reduced yield and biomass, mainly by inhibiting growth in the early stage of direct‐seeded rice. However, the wet direct‐seeding method decreased the losses in yield and biomass after wheat straw return.
Beneficial effects of arthrocen on neuroinflammation and behavior like depression in stroke in a murine model
Authors: Goudarzi Ramin , Zamanian Golnaz , Seyyedian Zahra , Mirzaee Saffari Partow , Dehpour Ahmad Reza , Partoazar Alireza 
Published: October 2022

AbstractStroke is a considerable reason for death, disability, socioeconomic loss, and depression in the world. Notably, many attempts to the reduction of the complications of poststroke injuries like depression have failed so far. In this study, we aimed to evaluate the anti‐inflammatory effect of arthrocen, avocado/soybean unsaponifiables (ASU), in the poststroke injuries like depression improvement in a mice model. We examined the antidepressant‐like effect of arthrocen using the forced swimming test and tail suspension test in mice subjected to stroke. Furthermore, immunohistochemistry of proinflammatory cytokines, IL‐10 and TNF‐α, and neural cell count were performed in the ischemic brain hippocampus of mice. Oral arthrocen reduced significantly (p < .001) the immobility time in the forced swimming test and tail suspension test in the stroke animals. Also, immunohistochemistry analysis of the hippocampus indicated significantly (p < .01) the reduction of IL‐10 and TNF‐α cytokines production. Nissl staining showed a significant (p < .0001) increase in the number of viable neurons in stroke mice receiving arthrocen. In conclusion, our data revealed the antidepressant activity of arthrocen in the stroke mice which may be the result of its anti‐inflammatory and neuroprotective role.
A comparison of multiband and multiband multiecho gradient‐echo EPI for task fMRI at 3 T
Authors: Fazal Zahra , Gomez Daniel E. P. , Llera Alberto , Marques José P. R. F. , Beck Thomas , Poser Benedikt A. , Norris David G. 
Published: October 2022

AbstractA multiband (MB) echo‐planar imaging (EPI) sequence is compared to a multiband multiecho (MBME) EPI protocol to investigate differences in sensitivity for task functional magnetic resonance imaging (fMRI) at 3 T. Multiecho sampling improves sensitivity in areas where single‐echo‐EPI suffers from dropouts. However, It requires in‐plane acceleration to reduce the echo train length, limiting the slice acceleration factor and the temporal and spatial resolution Data were acquired for both protocols in two sessions 24 h apart using an adapted color‐word interference Stroop task. Besides protocol comparison statistically, we performed test–retest reliability across sessions for different protocols and denoising methods. We evaluated the sensitivity of two different echo‐combination strategies for MBME‐EPI. We examined the performance of three different data denoising approaches: “Standard,” “AROMA,” and “FIX” for MB and MBME, and assessed whether a specific method is preferable. We consider using an appropriate autoregressive model order within the general linear model framework to correct TR differences between the protocols. The comparison between protocols and denoising methods showed at group level significantly higher mean z‐scores and the number of active voxels for MBME in the motor, subcortical and medial frontal cortices. When comparing different echo combinations, our results suggest that a contrast‐to‐noise ratio weighted echo combination improves sensitivity in MBME compared to simple echo‐summation. This study indicates that MBME can be a preferred protocol in task fMRI at spatial resolution (≥2 mm), primarily in medial prefrontal and subcortical areas.
Glycine‐β‐muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice
Authors: Jiang Jie , Ma Yuandi , Liu Yameng , Lu Dasheng , Gao Xiaoxia , Krausz Kristopher W. , Desai Dhimant , Amin Shantu G. , Patterson Andrew D. , Gonzalez Frank J. , Xie Cen 
Published: October 2022

Abstract
Nonalcoholic steatohepatitis (NASH) is a rapidly developing pathology around the world, with limited treatment options available. Some farnesoid X receptor (FXR) agonists have been applied in clinical trials for NASH, but side effects such as pruritus and low‐density lipoprotein elevation have been reported. Intestinal FXR is recognized as a promising therapeutic target for metabolic diseases. Glycine‐β‐muricholic acid (Gly‐MCA) is an intestine‐specific FXR antagonist previously shown to have favorable metabolic effects on obesity and insulin resistance. Herein, we identify a role for Gly‐MCA in the pathogenesis of NASH, and explore the underlying molecular mechanism. Gly‐MCA improved lipid accumulation, inflammatory response, and collagen deposition in two different NASH models. Mechanistically, Gly‐MCA decreased intestine‐derived ceramides by suppressing ceramide synthesis–related genes via decreasing intestinal FXR signaling, leading to lower liver endoplasmic reticulum (ER) stress and proinflammatory cytokine production. The role of bile acid metabolism and adiposity was excluded in the suppression of NASH by Gly‐MCA, and a correlation was found between intestine‐derived ceramides and NASH severity. This study revealed that Gly‐MCA, an intestine‐specific FXR antagonist, has beneficial effects on NASH by reducing ceramide levels circulating to liver via lowering intestinal FXR signaling, and ceramide production, followed by decreased liver ER stress and NASH progression. Intestinal FXR is a promising drug target and Gly‐MCA a novel agent for the prevention and treatment of NASH.
Examining the peatland shrubification‐evapotranspiration feedback following multi‐decadal water table manipulation
Authors: Moore Paul A. , Pypker Thomas G. , Hribljan John A. , Chimner Rodney A. , Waddington James Michael 
Published: October 2022

AbstractNorthern peatlands are globally important long‐term sinks of carbon due to their predominantly saturated conditions. However, these ecosystems are expected to become drier with climate change, potentially leading to shrubification. As such, the response of the shrubification–evapotranspiration (ET) feedback may be of critical importance to future peatland energy, water and carbon dynamics. We examined the effect of multi‐decadal peatland water table (WT) alteration at three adjacent sites with increasing depth to WT (WET, INTermediate, and DRY). In order to better understand the WT–shrubification–ET feedback, we measured peatland vegetation composition, microtopography and ET partitioning, where ET was measured at the ecosystem, microform, and leaf level using eddy covariance (EC), chambers and porometry, respectively. Averaged across microforms and WT treatments, there was a difference in the median measured leaf resistance (rleaf) between plant functional types ranging from 213 s m−1 for erect dwarf shrubs, 325 s m−1 for graminoids/sedges, and 520 s m−1 for prostrate dwarf shrubs. Scaled based on LAI, the low rleaf of erect dwarf shrubs dominated hummocks, where sites with a higher proportion of hummocks had lower median canopy resistance (rv) of 141, 133 and 130 s m−1 at the WET, INT and DRY sites respectively. Nevertheless, ET was highest at the WET site and similar between the INT and DRY sites, with greater evaporation from the moss surface at the WET site. Porometry and EC data along with a three‐source model were used to independently assess the evaporative contribution from the moss surface, which ranged from 17% to 40%. For moderate and persistent changes in WT from land‐use or climate change, our results suggest vegetation succession is minimal, but the microtopographic development and the concomitant differences in LAI for the various plant functional types is key to understanding changes in total ET and partitioning.
Hydrological process controls on streamflow variability in a glacierized headwater basin
Authors: Aubry‐Wake Caroline , Pradhananga Dhiraj , Pomeroy John W. 
Published: October 2022

AbstractMountain glacierized headwaters are currently witnessing a transient shift in their hydrological and glaciological systems in response to rapid climate change. To characterize these changes, a robust understanding of the hydrological processes operating in the basin and their interactions is needed. Such an investigation was undertaken in the Peyto Glacier Research Basin, Canadian Rockies over 32 years (1988–2020). A distributed, physically based, uncalibrated glacier hydrology model was developed using the modular, object‐oriented Cold Region Hydrological Modelling Platform to simulate both on and off‐glacier high mountain processes and streamflow generation. The hydrological processes that generate streamflow from this alpine basin are characterized by substantial inter‐annual variability over the 32 years. Snowmelt runoff always provided the largest fraction of annual streamflow (44% to 89%), with smaller fractional contributions occurring in higher streamflow years. Ice melt runoff provided 10% to 45% of annual streamflow volume, with higher fractions associated with higher flow years. Both rainfall and firn melt runoff contributed less than 13% of annual streamflow. Years with high streamflow were on average 1.43°C warmer than low streamflow years, and higher streamflow years had lower seasonal snow accumulation, earlier snowmelt and higher summer rainfall than years with lower streamflow. Greater ice exposure in warmer, low snowfall (high rainfall) years led to greater streamflow generation. The understanding gained here provides insight into how future climate and increased meteorological variability may impact glacier meltwater contributions to streamflow and downstream water availability as alpine glaciers continue to retreat.
Trabectedin use in soft‐tissue sarcoma patients in a real‐world setting: Data from an Italian national drug‐access registry
Authors: Vincenzi Bruno , Napolitano Andrea , Comandone Alessandro , Sanfilippo Roberta , Celant Simone , Olimpieri Pier P. , Di Segni Susanna , Russo Pierluigi , Casali Paolo G. 
Published: October 2022

AbstractTrabectedin is a marine‐derived anticancer drug approved for the treatment of patients with advanced soft‐tissue sarcomas (STS). Here, we aimed to analyze its use in a large cohort of STS patients treated in Italy in a real‐world setting. Data on STS patients treated with trabectedin in Italy were prospectively collected from January 2013 to December 2019 by the national drug regulator, the Italian Medicines Agency (AIFA). Time‐to‐off‐treatment (TToT) was defined as the time between the initial prescription of trabectedin and the date of treatment discontinuation for any cause. The impact of the different baseline covariates, including the initial prescribed dose of trabectedin, on TToT was evaluated using an accelerated failure time (AFT) models with log‐logistic distribution. In total, we analyzed data from 2633 sarcoma patients and 14 950 individual cycles of trabectedin. The median number of cycles of trabectedin received per patient was 3 (interquartile range 2‐7). The labeled 1.5 mg/sqm dose was used in 27.3% of all first prescriptions. Overall, the median TToT was 93 days. In the final AFT model, the variables significantly associated to longer TToT were female gender (+13% increase in TToT); ECOG performance status 0 (+50%); histological diagnosis of leiomyosarcoma (+22%), well‐differentiated/dedifferentiated liposarcoma (+72%) or myxoid liposarcoma (+61%); receiving treatment in a high‐volume center (+23%). In this large real‐world cohort of STS patients treated with trabectedin, our findings support the use of trabectedin in STS patients, in particular in leiomyosarcoma and liposarcoma patients, and highlight the role of treatment center volume in their management.
A functionalized separator enables dendrite‐free Zn anode via metal‐polydopamine coordination chemistry
Authors: Liu Yanfen , Liu Shude , Xie Xuesong , Li Zhicheng , Wang Pinji , Lu Bingan , Liang Shuquan , Tang Yan , Zhou Jiang 
Published: October 2022

AbstractDesigning a multifunctional separator with abundant ion migration paths is crucial for tuning the ion transport in rocking‐chair‐type batteries. Herein, a polydopamine‐functionalized PVDF (PVDF@PDA) nanofibrous membrane is designed to serve as a separator for aqueous zinc‐ion batteries (AZIBs). The functional groups (OH and NH) in PDA facilitate the formation of ZnO and ZnN coordination bonds with Zn ions, homogenizing the Zn‐ion flux and thus enabling dendrite‐free Zn deposition. Moreover, the PVDF@PDA separator effectively inhibits the shuttling of V‐species through the formation of VO coordination bonds. As a result, the Zn/NH4V4O10 battery with the PVDF@PDA separator exhibits enhanced cycling stability (92.3% after 1000 cycles at 5 A g−1) and rate capability compared to that using a glass fiber separator. This work provides a new avenue to design functionalized separators for high‐performance AZIBs.image
Analysis of the association between MICA gene polymorphisms and schizophrenia
Authors: Ren Xing , Mao Aiyou , Tan Shumin , Liu Jiaxiu , Wei Xiaobin 
Published: October 2022

AbstractBackgroundThe major histocompatibility complex (MHC) has been implicated in schizophrenia. This study aimed to explore the correlation between the major histocompatibility complex class I polypeptide‐related sequence A (MICA) polymorphisms and schizophrenia.MethodsA total of 220 Han schizophrenia patients, 47 Han healthy controls, 155 Li schizophrenia patients, and 48 Li controls were selected from Hainan Province, China. The diagnosis was made according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria. Sequencing‐based‐typing (PCR‐SBT) technology was used for MICA allele typing, and the correlation analyses of MICA gene polymorphism and schizophrenia were performed.ResultsIn the Han group, the three allele frequencies of MICA*002:01, MICA*A4, and MICA*A9 in the schizophrenia group were significantly higher than those in the healthy control group, and the differences were statistically significant (pc < 0.05; pc values were 0.024, 0.030, and 0.031, respectively). Yet, there was no difference in the MICA gene between the schizophrenia group and the healthy controls group in the Li population.ConclusionWe found MICA*002:01, MICA*A4, and MICA*A9 may be susceptibility alleles for schizophrenia in the Han population, while the MICA allele polymorphism in the Li population is not associated with schizophrenia in Chinese.
Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis
Authors: García‐Abellás Patricia , Ferrer Gómez Ana , Bueno Sacristán Diego , Piris Villaespesa Miguel , Talavera Yagüe María , Reguero Callejas María Eugenia , García‐Cosío Mónica 
Published: October 2022

AbstractLymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow
with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens.
Machine learning classification reveals robust morphometric biomarker of glial and neuronal arbors
Authors: Akram Masood A. , Wei Qi , Ascoli Giorgio A. 
Published: October 2022

AbstractNeurons and glia are the two main cell classes in the nervous systems of most animals. Although functionally distinct, neurons and glia are both characterized by multiple branching arbors stemming from the cell bodies. Glial processes are generally known to form smaller trees than neuronal dendrites. However, the full extent of morphological differences between neurons and glia in multiple species and brain regions has not yet been characterized, nor is it known whether these cells can be reliably distinguished based on geometric features alone. Here, we show that multiple supervised learning algorithms deployed on a large database of morphological reconstructions can systematically classify neuronal and glial arbors with nearly perfect accuracy and precision. Moreover, we report multiple morphometric properties, both size related and size independent, that differ substantially between these cell types. In particular, we newly identify an individual morphometric measurement, Average Branch Euclidean Length that can robustly separate neurons from glia across multiple animal models, a broad diversity of experimental conditions, and anatomical areas, with the notable exception of the cerebellum. We discuss the practical utility and physiological interpretation of this discovery.
Enhancing employees' duty orientation and moral potency: Dual mechanisms linking ethical psychological climate to ethically focused proactive behaviors
Authors: Gok Kubilay , Babalola Mayowa T. , Lakshman C. , Sumanth John J. , Vo Linh Chi , Decoster Stijn , Bansal Anjali , Coşkun Ahmet 
Published: October 2022

AbstractBased on social cognitive theory (SCT), we develop and test a model that links ethical psychological climate to ethically focused proactive behavior (i.e., ethical voice and ethical taking charge) via two distinct mechanisms (i.e., duty orientation and moral potency). Results from multi‐wave field studies conducted in the United States, Turkey, France, Vietnam, and India demonstrate that an ethical psychological climate indirectly influences employees' ethical voice and ethical taking charge behaviors through the dual mechanisms of duty orientation and moral potency. Additionally, we find that individuals' moral attentiveness strengthened these mediating processes. Together, these findings suggest that ethical psychological climate is an important antecedent of ethically focused proactive behavior by stimulating individuals' sense of duty and enhancing their moral potency, particularly when employees are already highly attuned to moral issues.