bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Outdoor Sports on Preschool Children’s Motor Skills Development
Authors: Saadu Usman 
Published: November 2022

The main purpose of this study was to examine the impact of outdoors sports on preschool children’s motor skills development in Ilorin Metropolis. The study adopted a pretest-posttest control group quasi-experimental research design. The population of this study consisted of all preschool children in public schools the Ilorin Metropolis, Kwara State. Purposive sampling technique was used to select 10 public schools who had preschooler with motor skill coordination problem. The sample size for this study comprised of 47 preschoolers who had motor skills coordination problems. The instrument was titled “Preschoolers performance scores (PPS)” were used to elicit information. It consisted of 10 items on a 3 likert-scale; options on “low”, “moderate” and “high” based on what preschoolers were able to do before and after exposing them to outdoor sports. Some of the items were kicking a ball at 5m target, throwing at a 2m target, running forward, balancing on right and left foot, throwing and catching a ball. The keys used were low 0.00-0.09, moderate 1.0-1.4 and high 1.5-2.5. Instruments were validated by lecturers in the department of Human Kinetics and reliability score was 0.79. The data were analyzed using frequency counts and percentage and Analysis of Covariance (ANCOVA) at 0.05 level of significance. The findings of the study revealed that there was a significant main effect of treatment on preschool children motor skill development (F(1; 47) = 264.448, P < 0.05). also, there was no significant main effect of gender on preschool children motor skill development (F (1; 47) =1.422; P > 0.05) and there was no significant interaction effect of treatment and gender on preschool children motor skill development ( (F (1; 47) =1.538; P >0.05). The study concludes that sports especially outdoor activities have positive impact on preschoolers’ motor skills development. Based on the findings, the study recommends among others that; teachers in preschools should be encouraged on the use of outdoor sports in improving motor skills development in children and workshops and trainings should be organized by school owners regularly, in order to educate teachers on new ways of improving motor skills development.
The Effect of Using Duolingo Application Towards Students’ Vocabulary Mastery at the Eighth Grade of SMPN 2 Banjarsari Lebak-Banten
Authors: Permatasari Puput , Sudirman Ade , Munawaroh Tatu 
Published: November 2022

The purpose of this research was to find out the emperical evidence of The Effect of Using Duolingo Application Toward Students’ Vocabulary Mastery at The Eighth Grade of SMPN 2 Banjarsari Lebak-Banten In Acaddemic Year 2021/2022. In this research, the quantitative methode was used and the research design was a quasi-experimental. To conduct the research, 76 students of eighth grade student of SMPN 2 Banjarsari Lebak academic year of 2021/2022 are choosen as the sample in this research. They were VIII A class as the experimental class, and VIII B class as the control class. Each class consisted of 25 students. This number was taken as the sample of this research by using Mr.Excel and SPSS 25. Duolingo application was used as an instrument in the experimental class while the control class uses the Hello English Application. Based on the calculation, the post-test mean scores of the experimental class was 70.12 while that of the control class was 59.36. The researcher got the result from testing with SPSS 25 t-test obtained the t-count =6.301in control class and signification value (p-value)=0.000 < a =0.05, and with t-test obtained the t-count= 6.463 in experimental class and significant value (p-value) =0.000 < a = 0.05 Ha is accepted and Ho is rejected. The result indicated that using Duolingo is effect towards students’ vocabulary mastery and had a moderate effect at the eighth grade of students SMPN 2 Banjarsari Lebak in the acaddemic year of 2021/2022.
Pemanfaatan Web Online Single Submission (OSS) Untuk Pembuatan Nomor Induk Berusaha (NIB) Pada UMKM Tanggamus
Authors: Khumaidi Ahmad , Suyono Suyono , Puspita Dian , Anggraeni Leni 
Published: November 2022

Dalam rangka meningkatkan investasi bisnis di Negara ini, sehingga pemerintah memberikan solusi terbaik dalam pengurusan legalitas usaha yang lebih mudah. Dengan adanya sistem Online Single Submission(OSS) menjadi salah satu solusi yang lebih baik dalam pengurusan Nomor Induk Berusaha (NIB). Nomor Induk Berusaha (NIB) menjadi identitas para pelaku usaha yang diterbitkan melalui OSS setelah pendaftaran yang dilakukan oleh para pelaku usaha. Nomor Induk Berusaha menjadi TDP (Tanda Daftar Perusahaan), Akses Kepabeanan, API (Angka Pengenal Impor) dalam melakukan kegiatan impor dan ekspor. UMKM Tanggamus selalu mengalami perkembanagn bisnis yang sangat pesat disetiap tahunnya tetapi masih banya para pelaku usaha yang belum mengerti dalam membuat legalitas usahanya sehingga dapat diberikan perlindungan oleh pemerintah. Masih banyak para pelaku usaha di UMKM Tanggamus yang belum mengerti pentingnya memiliki Nomor Induk Berusaha (NIB) serta belum mengetahu cara pendaftarnya melalui web OSS (Online Single Submissions). Tujuan penelitian ini memberikan penjelasan tentang pembuatan Nomor Induk Berusaha (NIB) sebagai legalitas usaha mikro kecil dan menengah (UMKM) yang ada di Kabupaten Tanggamus dengan memanfaatkan Web Online Single Submission (OSS). Pengabdian masyarakat ini bertujuan untuk memberikan solusi tentang legalitas usaha pada UMKM Tanggamus, kegiatan ini akan membantu dalam memperkenalkan, memberikan pengetahuan, dan menjadi referensi untuk para pelaku usaha UMKM Tanggamus sebagai pembuatan Nomor Induk Berusaha (NIB). Metode yang digunakan pada kegiatan ini terdapat beberapa tahapan, yaitu memberikan gambaran umum tentang Nomor Induk Berusaha (NIB), memberikan pelatihan tentang tehnis penggunaan Web Online Single Submission (OSS), dan memberikan pendampingan kepada para pelaku usaha UMKM Tanggamus. Hasil akhir dalam kegiatan ini diharapakan kepada para pelaku usaha UMKM Tanggamus dapat memahami pentingnya memiliki Nomor Induk Berusaha (NIB) sebagai legalitas dalam berusaha dengan terdaftarnya usaha UMKM Tanggamus di OSS (Online Single Submissions). Sehingga UMKM Tanggamus mendapatkan perlindungan Berusaha dari pemerintah, mendapatkan kemudahan dalam akses permodalan usaha, dan dapat menjadi usaha yang dapat diperdayakan oleh pemerintah
Pengaruh Pengurangan Setting Time (Wait on Cement) pada Semen Tahan Api dengan Penambahan Oil Well Cement
Authors: Rahmadika Bayu , Apriyanti Yayuk , Irvani Irvani 
Published: November 2022

Underground Coal Gasification (UCG) is a technology to extract coal deposits in the form of gas from mineral deposit without disassembling of overburden. There are some initial processes in UCG, one of them is cementing to glue the casing into the formation. This research-based laboratory using cement mixture that consists of Fire Mortar as the main ingredients with added Oil Well Cement (OWC) by 40%, 42.5%, 45%, 47.5%, 50%, 52.5%, 55%, 57.5% and 60% of the total weight of the cement mixture. Cement samples were then tested with hydration heat test, furnace test at temperatures of 300°C to 900°C and UCS test of a sample at normal temperature as well as samples that have undergone combustion at a certain temperature. Composition of OWC>50% have faster setting time on the 29th to 40th hours with maximum hydration temperature of 34.4°C on the 11th to the 12th hour as well as getting the optimal composition of Fire Mortar which is 42.5% and OWC which is 57.5%. Composition of 50-60% Fire Mortar have a heat resistance to a maximum of 900°C so they don’t experience failure and cracks which make a sample split. Ofter than that, composition of 50-60% OWC on average have a greater compressive strength with the highest compressive strength value of 1.75 MPa at a temperature of 500°C.
Efeitos da poliamina espermidina no metabolismo e na longevidade
Authors: Pereira Juliana Andrade , Abreu Carla Dayana Durães , Abreu Luciana Durães , Magalhães Paloma Gomes de Araújo , Almeida Daniele Santos , Antunes Ada Lorrana Medeiros , Rocha Bianca Portugal Cardoso , Andrade Fernanda Mariane Pereira , Sergio Vieira Machado Mauro , Machado Mauro Sérgio Vieira , Gusmão Yure Gonçalves 
Published: November 2022

A poliamina espermidina é encontrada em todos os seres eucariotos e na grande parte dos procariontes. Conforme sua natureza policatiônica, as poliaminas podem juntar facilmente a biomoléculas com carga negativa, especialmente o DNA, RNA, proteínas e fosfolipídios, modificando em muitas ocasiões a função dessas macromoléculas. Dada a sua habilidade em se ligar em outras moléculas, eles estão associados em diversas funções, sobretudo vinculadas ao crescimento, autofagia, sobrevivência e proliferação celular. Objetivou-se com este estudo identificar os efeitos da poliamina espermidinano metabolismo e na longevidade. Trata-se de um estudo de revisão de literatura integrativa, foi utilizada as seguintes bases de dados SciELO, PUBMED, LILACS e Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes). A espermidina exerce nas atividades de promoção da longevidade sendo ligada à sua capacidade de manter proteostase por meio da estimulação da autofagia citoprotetora, ocasionando uma retirada do acúmulo intracelular de detritos tóxicos produzidos pelo envelhecimento e doenças. Além da indução da autofagia, a atuação da espermidina tem sido referente à modulação de espécies reativas de oxigênio, replicação, transcrição e tradução de DNA, propriedades antiinflamatórias, atividade mitocondrial modificada, proteostase melhorada, crescimento da hipusinação. As poliaminas têm uma relação complexa e difusa com as doenças. Podendo ser prejudiciais, neutras ou benéficas, variando de acordo com a poliamina e a doença específica. Contudo, parece que a espermidina expressou efeitos mais positivos, estando em concordância com seus efeitos benéficos expressados acerca do tempo de vida e o estresse.
Desafios e enfrentamentos para a prática clínica do enfermeiro: Scoping review
Authors: Fogliatto Danielle Borges , Peres Aida Maris , Ros Carla da , Kalinowski Carmen Elizabeth 
Published: November 2022

Objetivo: Identificar os desafios e as potencialidades para a prática clínica do enfermeiro na atenção primária à saúde frente à COVID-19. Método: Scoping Review, conforme Joanna Briggs Institute (JBI), com a questão norteadora: “Quais os desafios e as potencialidades da prática clínica do enfermeiro na atenção primária à saúde frente à COVID-19?”. Inclusos estudos nacionais e internacionais, nos idiomas inglês, português e espanhol, no espaço temporal de 2019 a 2022, com buscas em quatro bases de dados. Resultados: Encontrados 9089 artigos e selecionados oito como amostra final. Os estudos destacaram alguns dos desafios com o referencial para COVID-19, como a jornada de trabalho excessiva dos enfermeiros, falta de educação continuada, os Equipamentos de Proteção Individual (EPI) insuficientes, o subfinanciamento da APS, entre outros, bem como as potencialidades, como a adaptabilidade e a força de trabalho dos profissionais de saúde, principalmente dos enfermeiros. Conclusões: Evidenciado que os desafios para a prática clínica do enfermeiro frente à COVID-19 estão no enfrentamento e superação das questões estruturais, econômicas, sociais e emocionais, geradas por situações como a falta de equipamentos e materiais, e trabalhar com o desconhecido. As potencialidades relacionam-se às possibilidades de desenvolvimento de competências clínicas e à adaptabilidade da força de trabalho para atender com segurança e qualidade as pessoas.
Association between energy intake patterns and outcome in US heart failure patients
Authors: Fang Zhang , Wang Zhe , Cao Xiaodi , Wang Ze-Mu , Yu Chuanchuan , Ju Weizhu , Li Dianfu 
Published: November 2022

BackgroundThe association between dietary energy patterns, calories, and the outcomes of heart failure (HF) is still unclear.ObjectivesTo evaluate the proper energy intake patterns and daily calorie intake in patients with heart failure among US adults.MethodsThe data were derived from the 2001–2014 National Health and Nutrition Examination Survey (NHANES). A calorie intake pattern variable was created using latent class analysis (LCA) based on the calorie ratio of three major nutrients. Cox proportional hazard regression models were used to evaluate the hazard ratios (HR) and 95% confidence intervals (CI) of the association between calorie intake and energy patterns. The primary endpoint was all-cause mortality.ResultsAmong 991 participants (mean age 67.3 ± 12.9 years; 55.7% men) who suffered from heart failure; the median calorie intake was 1,617 kcal/day [interquartile range (IQR): 1,222–2,154 kcal/day]. In the multivariable-adjusted model, moderate malnutrition was more frequent to death (HR: 2.15; 95% CI: 1.29–3.56). Low-carbohydrate pattern (LCP) and median-carbohydrate pattern (MCP) had lower risks of death compared to high-carbohydrate pattern (HCP) (LCP: HR: 0.76; 95% CI: 0.59–0.97; MCP: HR: 0.77; 95% CI: 0.60–0.98). No association between different amounts of calorie intake and all-cause mortality was found. There was an adjusted significant interaction between calorie intake and energy intake patterns (p = 0.019). There was a linear relationship between energy intake through HCP and all-cause mortality (p for non-linear = 0.557). A non-linear relationship between energy intake through MCP and all-cause mortality (p for non-linear = 0.008) was observed.ConclusionBoth LCP and MCP, compared to HCP, were associated with better outcomes in the HF population. The relationship between energy intake and all-cause death may be influenced by energy intake patterns in HF patients.
Case report: Left bundle branch pacing guided by real-time monitoring of current of injury and electrocardiography
Authors: Shen Jiabo , Jiang Longfu , Wu Hao , Li Hengdong , Zhong Jinyan , Pan Lifang 
Published: November 2022

BackgroundLeft bundle branch (LBB) pacing (LBBP) has recently emerged as a physiological pacing mode. Current of injury (COI) can be used as the basis for electrode fixation position and detection of perforation. However, because the intermittent pacing method cannot monitor the changes in COI in real time, it cannot obtain information about the entire COI change process during implantation.Case summaryLeft bundle branch pacing was achieved for treatment of atrioventricular block in a 76-year-old female. Uninterrupted electrocardiogram and electrogram were recorded on an electrophysiology system. In contrast to the interrupted pacing method, this continuous pacing and recording technique enables real-time monitoring of the change in ventricular COI and the paced QRS complex as the lead advances into the interventricular septum. During the entire screw-in process, the COI amplitude increased and then decreased gradually after reaching the peak, followed by a small but significant, rather than dramatic, decrease.ConclusionThis case report aims to demonstrate the clinical significance of changes in COI and QRS morphology for LBBP using real-time electrocardiographic monitoring and filtered and unfiltered electrograms when the lead is deployed using a continuous pacing technique. The technique could be used to confirm LBB capture and avoid perforation.
Aspirin for the prevention of preeclampsia: A systematic review and meta-analysis of randomized controlled studies
Authors: Wang Yixiao , Guo Xiaojun , Obore Nathan , Ding Hongjuan , Wu Chengqian , Yu Hong 
Published: November 2022

BackgroundThe results of randomized controlled studies on aspirin for the prevention of preeclampsia (PE) are conflicting, and some of the related meta-analyses also have limitations or flaws.Data sourcesA search was conducted on PubMed, Embase, and Cochrane Central Register of Controlled Trials databases, with no time or language restrictions.Study eligibility criteriaRandomized controlled studies comparing aspirin for the prevention of PE were conducted.MethodsSystematic reviews were performed according to the Cochrane Manual guidelines. A fixed-effects model or a random-effects model was chosen to calculate pooled relative risks with 95% confidence intervals based on the heterogeneity of the included studies. The study aimed to investigate the effect of aspirin on the development of PE in high-risk and general populations of women. Publication bias was assessed by funnel plots. All included studies were assessed for bias by the Cochrane Manual of Bias Assessment. Subgroup analyses were conducted on the aspirin dose, time of initial aspirin intervention, and the region in which the research was conducted, to explore the effective dose of aspirin and time of initial aspirin intervention and to try to find sources of heterogeneity and publication bias.ResultsA total of 39 articles were included, including 29 studies involving pregnant women at high risk for PE (20,133 patients) and 10 studies involving a general population of pregnant women (18,911 patients). Aspirin reduced the incidence of PE by 28% (RR 0.72, 95% CI 0.62–0.83) in women at high risk for PE. Aspirin reduced the incidence of PE by 30% in the general population (RR 0.70, 95% CI 0.52–0.95), but sensitivity analyses found that aspirin in the general population was not robust. A subgroup analysis showed that an aspirin dose of 75 mg/day (RR 0.50, 95% CI 0.32–0.78) had a better protective effect than other doses. Starting aspirin at 12–16 weeks (RR 0.62, 95% CI 0.53–0.74) of gestation or 17–28 weeks (RR 0.62, 95% CI 0.44–0.89) reduced the incidence of PE by 38% in women at high risk for PE, but the results were more reliable for use at 12–16 weeks. Heterogeneity and publication bias of the included studies may be mainly due to the studies completed in Asia.ConclusionAspirin is recommended to be started at 12–16 weeks of pregnancy in women at high risk for PE. The optimal dose of aspirin to use is 75 mg/d.Systematic review registration[www.ClinicalTrials.gov], identifier [CRD42022319984].
Follicular fluid steroid and gonadotropic hormone levels and mitochondrial function from exosomes predict embryonic development
Authors: Yu Li , Liu Miao , Xu Shiji , Wang Zhenxin , Liu Te , Zhou Jiaye , Zhang Doudou , Dong Xi , Pan Baishen , Wang Beili , Liu Suying , Guo Wei 
Published: November 2022

PurposeHuman follicular fluid (FF) is a complex biological fluid that contributes to the micro-environment of oocyte development. The aim of this study was to evaluate the role of steroid and gonadotropic hormones levels and mitochondrial function in embryo development during in vitro fertilization cycles.MethodsThis was a cohort study of 138 women receiving IVF/ICSI, including 136 FF samples from 109 infertile women. FF steroid and gonadotropic hormones levels were tested by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassays. The mRNA expression levels of mitochondrial electron transport chain (ETC) complex genes from FF exosomes were detected by qPCR.ResultsAnalysis of these individual FF concentrations revealed that LH and FSH concentrations were higher in follicles in which the oocyte developed into a top quality (TQ) blastocyst (LH: 9.44 ± 2.32mIU/ml, FSH: 9.32 ± 1.01mIU/ml) than those in which there was a failure of fertilization (LH: 5.30 ± 0.84mIU/ml, FSH: 6.91 ± 0.62mIU/ml). In contrast, follicular cortisone concentrations were lower for oocytes that resulted in a TQ blastocyst (12.20 ± 0.82mIU/ml). The receiver operating characteristic analysis showed that FF LH and FSH levels predicted TQ blastocyst with excellent AUC value of 0.711 and 0.747. Mitochondrial ETC complex I and III mRNA levels were increased in the FF exosomes of TQ blastocyst. Correlation analysis showed that mRNA levels of ETC complex I was positively correlated with LH and FSH levels in FF.ConclusionThe levels of FF steroid and gonadotropic hormones from single follicle can predetermine subsequent embryo development to some extent. Furthermore, impaired exosome mitochondrial dysfunction is a potiential event that causes hormone change in embryo development.
Study on the differences of gut microbiota composition between phlegm-dampness syndrome and qi-yin deficiency syndrome in patients with metabolic syndrome
Authors: Shang Haonan , Zhang Lu , Xiao Tiegang , Zhang Li , Ruan Jun , Zhang Qiang , Liu Kaili , Yu Zhonghai , Ni Yueqiong , Wang Bing 
Published: November 2022

BackgroundMetabolic syndrome (MS) is a group of complex medical conditions that can lead to serious cardiovascular and cerebrovascular diseases. According to the theory of traditional Chinese medicine (TCM), MS can be divided into two main subtypes termed ‘phlegm-dampness syndrome’ (TSZE) and ‘qi-yin deficiency syndrome’ (QYLX). At present, the research into intestinal microbiota of different TCM syndromes of MS and its association with clinical manifestation is lacking.Materials and methodsUsing 16S rRNA sequencing, we performed a cross-sectional analysis of human gut microbiota between two different TCM syndromes (QYLX and TSZE, n=60) of MS, and their differences with healthy participants (n=30).ResultsWe found that the QYLX and TSZE groups differ from the healthy control group in the overall gut microbiota composition, and some specific microbial taxa and functional pathways. Moreover, significantly differentially abundant taxa and distinct BMI-correlated taxa were observed between QYLX and TSZE groups, suggesting the potential contribution of gut microbiota to the distinction between the two TCM syndromes. The predicted functional profiles also showed considerable differences, especially pathways related to amino acid metabolism and lipopolysaccharide synthesis.ConclusionOur study highlights the gut microbiota’s contribution to the differentiation between two TCM syndromes of MS and may provide the rationale for adopting different microbiota-directed treatment strategies for different TCM syndromes of MS in the future.
Neonatal outcomes and congenital malformations in children born after progestin-primed ovarian stimulation protocol
Authors: Li Danjun , Hu Zhijie , Chen Qiuju , Chai Weiran , Cai Renfei , Kuang Yanping , Lu Xuefeng 
Published: November 2022

PurposeThe purpose of this study is to assess the safety of progestin-primed ovarian stimulation (PPOS) protocol regarding the neonatal outcomes and congenital malformations in babies born after in vitro fertilization (IVF) and frozen embryo transfer (FET).MethodsIn this large retrospective cohort study, a total of 16,493 infants born between 1 September 2013 and 31 July 2021 from IVF and FET cycles after treatment with either PPOS (n = 15,245) or gonadotropin-releasing hormone antagonist (GnRH-ant) (n = 1,248) were finally enrolled. The primary outcome measure was the incidence of congenital malformations. The secondary outcome measures were rates of low birth weight (LBW), very low birth weight (VLBW), preterm birth (PTB), very preterm birth (VPTB), and early neonatal death.ResultsBirth characteristics for both singletons and twins regarding the sex of infants, gestational age, birth weight, and birth length were comparable between the PPOS group and the GnRH-ant group. Rates of LBW, VLBW, PTB, VPTB, and early neonatal death were also similar. The reanalysis using propensity score matching (PSM) and multivariable logistic regression indicated that the PPOS protocol could not increase the risk of adverse neonatal outcomes compared with the GnRH-ant protocol. Furthermore, no significant difference was observed in the overall incidence of congenital malformations in live-born babies. After PSM and controlling for all confounders, the results remained insignificant with an adjusted odds ratio of 0.66 [95% confidence interval (CI) 0.32–1.34] and 2.43 [95% CI 0.97–6.06], respectively, for singletons and twins.ConclusionsOur study suggests that compared with GnRH-ant treatment for IVF, the PPOS protocol could not produce a negative effect on the newborn population in terms of neonatal outcomes and congenital malformations.