bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis value of 18 F-Fluoro-D-glucose positron emission tomography-computed tomography in pulmonary hamartoma
Authors: Ye Sheng , Meng Shen , Bian Shuang , Zhao Cuicui , Yang Jin , Lei Wei 
Published: September 2022

Abstract
Purpose: The diagnosis of pulmonary hamartoma (PH) based on computed tomography (CT) is a challenge, especially in patients with atypical imaging characteristics. This study was aimed at summarizing the imaging characteristic of 18F-Fluoro-D-glucose positron emission tomography-computed tomography (18F-FDG PET-CT) in PH and exploring the application value of PET in the diagnosis of PH.
Data and Methods: Patients diagnosed with PH who had undergone PET-CT from our hospital were retrospectively reviewed. And other cases were publications regarding the use of PET-CT in patients with PH were retrieved from the Cochrane Library, PubMed, Excerpta Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI) and Wanfang databases, until June 2022. Patients’ symptoms, imaging characteristics of chest CT, tumor markers, PET-CT characteristics, the reason for PET-CT and the complications were analyzed.
Results: In this retrospective study, a total of 219 patients were diagnosed with PH and had been examined by PET-CT. 23 of the cases were patients of our hospital from January 2008 to June 2022. Others were collected from the literature. the mean diameter of most lung hamartoma lesions is 1.68 cm (0.4-5.5cm). Most of their SUVmax values were lower than internationally recognized cut-off value (SUVmax=2.5). PET-CT was superior to CT in diagnosing PH but there was a consistency of diagnostic efficiency between CT and PET-CT. ROC curve analysis showed that the AUC(Area under curve) of SUVmax was 0.905, and the optimal diagnostic threshold was SUVmax>2.65.
Conclusion: PET-CT might be a useful tool to diagnose PH, even though with atypical radiographic features, and show better diagnostic accuracy than CT.
CircBRD7 inhibits tumor growth and metastasis in nasopharyngeal carcinoma via forming a positive feedback regulation loop with its host gene
Authors: Wei Jianxia , Li Mengna , Chen Shipeng , Xue Changning , Zhan Yuting , Zheng Lemei , Duan Yumei , Deng Hongyu , Tang Faqing , Fan Songqing , Xiong Wei , Li Guiyuan , Zhou Ming 
Published: September 2022

Abstract
Background: BRD7 was identified as a tumor suppressor in nasopharyngeal carcinoma (NPC). Circular RNA (CircRNAs) are involved in the occurrence and development of NPC as oncogenes or tumor suppressors. However, the function and mechanism of the circRNAs derived from BRD7 in NPC are not well understood.
Methods: Bioinformatics analysis, agarose gel electrophoresis and Sanger sequencing were performed to screen and identify the circular RNA derived from BRD7. CCK-8, colony formation, wound healing and transwell assays were used to evaluate the cell proliferation, migration and invasion abilities of circBRD7. The ChIP-qPCR assay was performed to investigate the regulatory mechanism of circBRD7 on BRD7. Xenograft tumor and lung metastasis models were constructed to confirm the effect of circBRD7 on tumor growth and metastasis.
Results: CircBRD7 was identified as a circular RNA derived from BRD7 that inhibited cell proliferation, migration, invasion of NPC cells as well as the xenograft tumor growth and metastasis in vivo. Mechanistically,circBRD7 promoted the transcription and expression of BRD7 by enhancing the enrichment of H3K27ac in the promoter region of its host gene, and BRD7 promoted the expression of circBRD7, thus circBRD7 formed positive feedback loop with BRD7 to inhibit NPC development and progression. Moreover, restoration of BRD7 expression rescued the inhibitory effect of circBRD7 on the proliferation, migration and invasion of NPC cell and xenograft tumor growth and metastasis. In addition, circBRD7 was expressed at low levels in NPC tissues, which was positively correlated with BRD7 expression and negatively correlated with the clinical stage of NPC patients. The combination of circBRD7 and BRD7 could be used as an important molecular marker for the evaluation of NPC progression.
Conclusions: Taken together, circBRD7 inhibits the tumor growth and metastasis of NPC via forming positive feedback loop with its host gene, and targeting the circBRD7/BRD7 axis is a promising strategy for the clinical diagnosis and treatment of NPC.
Married women’s decision to delay childbearing, and loneliness, severe psychological distress, and suicidal ideation under crisis: Online survey data analysis from 2020 and 2021
Authors: Matsushima Midori , Yamada Hiroyuki , Kondo Naoki , Arakawa Yuki , Tabuchi Takahiro 
Published: September 2022

Abstract
Background
The COVID-19 pandemic has affected every aspect of our lives, including the decision to become pregnant. Existing literature suggests that infertility and the decision to delay childbearing at a younger age are associated with a lower level of well-being and regrets when women start to desire a baby. Thus, the decision to delay childbearing due to the pandemic could negatively affect the well-being of women. This study focuses on how pregnancy decisions affect the well-being of women during the COVID-19 pandemic.
Methods
From the Japan COVID-19 and Society Internet Survey, a nationally representative web-based survey, 768 observations of married women aged 18 to 50 years who had the intention of getting pregnant during the pre-pandemic period (conducted in 2020 and 2021) were used. Loneliness, severe psychological distress, and suicidal ideation were used as well-being indicators. For pooled data, a generalised estimated equation (GEE) model was used to estimate how pregnancy decision related to well-being indicators. For a sub-analysis, the sample was divided by the survey year and a Poisson regression model was used.
Results
Approximately 20% of married women reported that their decision to postpone childbearing was due to the pandemic. The GEE analysis showed an association between delaying childbearing and severe psychological distress, with the prevalence ratio (PR) being 2.06 [95% CI (1.40–3.03)]. Furthermore, loneliness and suicidal ideation that occurred after the beginning of the pandemic were significantly related to the decision to delay childbearing—1.55 [95% CI (1.03,2.34)] and 2.55 [95% CI (1.45–4.51)], respectively. Moreover, these PRs were larger for 2021 compared to 2020.
Conclusion
During the COVID-19 pandemic, approximately one-fifth of married women who had childbearing intentions before the pandemic decided to postpone pregnancy. They exhibited a deteriorated mental health state. Furthermore, the negative associations were larger in 2021 compared to 2020. Loneliness has negative consequences for both mental and physical health, as well as elevated severe psychological distress and suicidal ideation among those who decided to postpone pregnancy. Therefore, the current results should not be overlooked by society.
Groundwater vulnerability assessment using a GIS-based DRASTIC method in Erbil Dumpsite area (Kani Qirzhala), Central Erbil Basin, North Iraq
Authors: Hamed Masoud H. , Dara Rebwar N. , Kirlas Marios C. 
Published: September 2022

Abstract

Groundwater vulnerability assessment is an essential step for the efficient management of groundwater resources, especially in areas with intensive anthropogenic activities and groundwater pollution. In the present study, the DRASTIC method was applied using geographic information system (GIS) to evaluate groundwater vulnerability zones in Erbil Dumpsite area, Central Erbil Basin, North Iraq. Results showed that the area was classified into the following vulnerability classes: very low (16.97%), low (27.67%), moderate (36.55%) and high (18.81%). The southern, south-eastern and northern part of the study area had the highest vulnerability potential, whereas the central-northern, northern and north-western portion of the study area revealed the lowest vulnerability potential. Moreover, results of the single-parameter sensitivity analysis showed that amongst the seven DRASTIC parameters the unsaturated zone and the aquifer media were the most influencing parameters. Finally, the correlation of 25 nitrate concentration values with the final vulnerability map, using the Pearson correlation coefficient, gave a satisfactory result equal to R = 0.72.
Off-axis high-speed camera-based real-time monitoring and simulation study for laser powder bed fusion of 316L stainless steel
Authors: Thanki Aditi , Jordan Carlos , Booth Brian G. , Verhees Dries , Heylen Rob , Mir Mariam , Bey-Temsamani Abdellatif , Philips Wilfried , Witvrouw Ann , Haitjema Han 
Published: September 2022

Abstract
In-situ monitoring and post-process metrology form a basis to better understand the fundamental physics involved in the Laser Powder Bed Fusion (LPBF) process and ultimately to determine its stability. By utilizing high-speed imaging, various process signatures are produced during single track formation of 316L stainless steel with various combinations of laser power and scan speed. In this study, we evaluate whether these signatures can be used to detect the onset of potential defects. To identify process signatures, image segmentation and feature detection are applied to the monitoring data along the line scans. The process signatures determined in the current study are mainly related to the features like the process zone length-to-width ratio, process zone area, process zone mean intensity, spatter speed and number of spatters. It is shown that the scan speed has a significant impact on the process stability and spatter formation during single track fusion. Simulations with similar processing conditions were also performed to predict melt pool geometric features. Post-process characterization techniques such as X-ray computed tomography and 2.5-D surface topography measurement were carried out for a quality check of the line track. An attempt was made to correlate physics-based features with process-related defects and a correlation between the number of keyhole porosities and the number of spatters was observed for the line tracks.
Study the ISO-FDTD algorithm to processing higher-order dielectric function in SFM-FDTD
Authors: gu ke-da , xie jin , yang hong-wei 
Published: September 2022

Abstract
In this paper, we use an ISO-FDTD (improved shift operator finite-difference time-domain, proposed by others) algorithm to further process some more complex dielectric functions like critical models, and several higher order Lorentz models fitted by ourselves, these function models totally have 6 ~ 8 susceptibility terms, and each term was consisted by two complex poles (Lorentz model). Our working supporting the universal applicability of ISO-FDTD for processing higher-order complex dispersive materials. And we applied this ISO-FDTD algorithm in SFM-FDTD (split-field method FDTD) to simulate dispersion media under oblique incidence. The simulation results meet well with the analytical solutions. Researchers can have an alternate option besides ADE and PLRC methods when processing high-order dispersive media in SFM-FDTD.
pH‑EGFET sensor based on the surface modification of MacroPSi with Au-NPs
Authors: Slewa Lary H. , Sabah Fayroz A. , Gozeh Bestoon A. , Othman Hazha Omer , Abbas Tariq A. , Ahmed Naser M. 
Published: September 2022

AbstractA heterostructure of (Au-NPs/MacroPSi) was synthesized by filtering a colloidal of gold nanoparticles (Au-NPs) into MacroPSi layer using high voltage electrophoretic deposition (HVEPD). The aim of that is to enhance the performance of MacroPSi used as a pH-EGFET sensor. For this purpose, the MacroPSi with an average pore size of 1.388 µm was synthesized by anodic etching of Si wafer, and a spherical shape of Au-NPs with size varied in the range of 5 to 25 nm were synthesized in ethanol by pulsed laser ablation in liquid (PLAL) technique. The density of (Au-NPs) on the surface and inside the pores of MacroPSi was determined utilizing FESEM. The pH sensitivity, linearity, and hysteresis of the heterostructure Au-NPs/MacroPSi pH-EGFET sensor were measured in the pH range from 2 to 12. The outcomes indicated that the membrane exhibited a significantly enhanced pH sensitivity value of 83.57 mV/pH with linear regression of 99.37%, and hysteresis of 3 mV and 5 mV in the acid and base pH cycles, respectively. The presence of Au-NPs improve the sensitivity and stability of the sensor due to deactivate of the Si-h surface bond and enhancement the conducting on the surface of MacroPSi, and also provide better Ohmic contact to the PSi. The research work confirms the feasibility of using the hetero structures (Au-NPs/MacroPSi) as extended get for acidity and basicity detection.
Human embryonic stem cells overexpressing dopaminergic transcription factors survive and differentiate in the substantia nigra in vivo
Authors: Ramos-Acevedo Rodrigo , Morato-Torres Carmen Alejandra , Bernal-Conde Luis Daniel , Padilla-Godínez Francisco Javier , Palomero-Rivero Marcela , Zafar Faria , Schüle Birgitt , Guerra-Crespo Magdalena 
Published: September 2022

Abstract

Background: Degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD) is responsible for motor and cognitive impairment. Replacing the dopaminergic cell population in the SNpc to restore normal dopamine levels is a potential therapeutic approach. However, improving neuronal integration still requires a reliable cell source for transplantation and a profound understanding of the effects of the local microenvironment on transplanted cells. We have previously shown that embryoid bodies (EBs)-derived cells from mouse embryonic stem cells overexpressing the dopaminergic transcription factor Lmx1a engrafted into SNpc develop tyrosine hydroxylase (TH)-positive phenotype. In the present work, we transplanted EBs-derived cells from genetically engineered human embryonic stem cells (hESCs), overexpressing the dopaminergic transcription factors LMX1A, FOXA2, and OTX2 (hESC-LFO). We determined their potential to differentiate into TH-expressing neurons in the SNpc of anin vivoPD model. Methods: EBs-derived cells from genetically the engineered hESCs-LFO cell line were transplanted, and their neuronal differentiation potential was determined in the SNpc of anin vivoPD model with 6-hydroxy dopamine (6-OHDA). Three rat groups were designed as follows: Untreated (healthy rats), sham (rats administered with saline solution), and 6-OHDA (rats lesioned with 6-OHDA). A one-way ANOVA test was performed for statistical analysis. Results: Neural rosettes, a fundamental developmental hallmark of neuroepithelial tissue, were found at 7 and 15 days post-transplantation (dpt) in ~ 70% of the transplanted brains in all three conditions: Untreated, sham, and 6-OHDA. The majority of the neural rosettes corresponded to the lumen formation stage. In comparison, no graft survival was observed in EB transplants derived from unmodified hESCs. Interestingly, at 30 dpt, hESC-LFO engrafted cells showed neuronal morphology and positive immunolabeling for TH in all the brains exhibiting surviving transplants: 10% 6-OHDA rats, 0% sham, and 100% untreated rats. Conclusions: Overall, our results show that overexpression of LFO factors favors short-term survival while strongly initiating neural differentiation of hESC-derived cells in SNpc surviving grafts by forming neural rosettes and differentiating into TH-positive cells.
Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET
Authors: Narciso Lucas , Dassanayake Praveen , Liu Linshan , Pinto Samara , Anazodo Udunna , Soddu Andrea , Lawrence Keith St 
Published: September 2022

Abstract
Background: Quantification of cerebral glucose metabolism by dynamic [ 18 F]FDG PET is often limited to the cerebral metabolic rate of glucose (CMRGlu) due to the challenges associated with obtaining microparameters at the voxelwise level (e.g., noise, choice of parameter estimation method, and input function quality). Efforts to avoid invasive arterial sampling include the simultaneous estimation (SIME) approach, which models the image-derived input function (IDIF) by series of exponentials with coefficients obtained by fitting time activity curves (TACs) from multiple volumes-of-interest. A limitation of SIME is the assumption that the input function can be modelled accurately by a series of exponentials. Alternatively, we propose a SIME approach based on the two-tissue compartment model to extract a high signal-to-noise ratio (SNR) modelderived input function (MDIF) from the whole-brain TAC. The purpose of this study is to present the MDIF approach and its implementation in the analysis of animal and human data.
Methods: Simulations were performed to assess the MDIF approach in terms of accuracy, by evaluating a range of temporal resolutions; and precision, by adding noise to simulated TACs. The derived MDIFs were compared to the gold standard using retrospective data from animal experiments ( n = 5). Retrospective data from neurologically healthy volunteers ( n = 18) were used to extract macro- and microparameters from dynamic [ 18 F]FDG PET data.
Results: Simulations demonstrated that extracting the MDIF from a whole-brain TAC requires using a sampling rate sufficient to minimize truncation errors. The MDIF approach improved the precision of estimated [ 18 F]FDG microparameters compared to the original SIME method. Good agreement between MDIFs and measured AIFs was found in the animal experiments. Similarly, the ratio of the area under the curve for MDIF to IDIF in the human experiments was 1.05 ± 0.11, resulting in agreement in grey matter CMRGlu: 24.2 ± 3.5 and 24.4 ± 3.8 mL/100 g/min for MDIF and IDIF, respectively. The MDIF method was superior in characterizing the first pass of [ 18 F]FDG. Groupwise macro- and microparameter voxelwise images obtained with the MDIF showed the expected patterns.
Conclusions: A model-driven SIME method was proposed to derive high SNR input functions. Simulations indicate that [ 18 F]FDG rate constants obtained with the MDIF had higher precision than corresponding estimates from the original IDIF SIME approach, which is attributed to the MDIF method requiring fewer fitting parameters to characterize the input function.
Efficacy of Robot-assisted Hepaticojejunostomy and Laparoscopic-assisted Hepaticojejunostomy in Pediatric Congenital Choledochal Dilatation ： A System Review and Meta-analysis
Authors: Zhang Ruifeng , Liu Shaowen , Li Tengfei , Zhan Jianghua 
Published: September 2022

Abstract
Purpose: The efficacy of Robot-assisted hepaticojejunostomy (RAHJ) and Laparoscopic-assisted hepaticojejunostomy (LAHJ) in children with congenital choledochal dilatation has been a topic of much debate and controversy. The purpose of this study was to evaluate the role of RAHJ and LAHJ in pediatric congenital choledochal dilatation.
Method: The review program has been prospectively registered (PROSPEROID: CRD42022306868). We searched the PubMed, Embase, Cochrane, CBM, VIP, Web of Science, CNKI databases and Wanfang databases from March 2021. The Mantel–Haenszel method and a random effects model were used to figure out the hazard ratio (95% CI).
Results: Ten studies evaluated 869 subjects (332 in the robotic group and 537 in the laparoscopic group), meeting all inclusion criteria. Compared with the laparoscopic group, robotic group demonstrated fewer postoperative complications [p = 0.0009; OR = 0.34 (95% CI, 0.18-0.64); I2= 3%], shorter postoperative hospital stay [p < 00001; MD = -2.05 (95% CI, -2.40-1.70); I2 = 0%] and less intraoperative bleeding [p < 0.008; MD = -10.08 (95% CI, -18.80--2.81); I2 = 99%]. There was no significant difference in operative time between the two groups [p = 0.10; MD = 24.53 (95% CI, -5.11-54.17); I2 = 99%]. The same situation happened in short-term complication outcomes [p = 0.06; RR = 0.45 (95% CI, 0.19-1.04); I2 = 0%]. However, children in the RAHJ group had significantly lower levels of long-term complications [p = 0.04; OR = 0.41 (95% CI, 0.17-0.96); I2 = 0%]. Hospitalization costs were significantly higher in the RAHJ group [p < 0.00001; OR = 27113.86 (95% CI, 26307.24-27920.48); I2 = 0%]. For overall complications, subgroup analysis of literature published after 2020 and of literature with high quality scores showed a significant decrease in the RAHJ group.
Conclusion: In children with congenital choledochal dilatation, RAHJ is associated with reduced intraoperative bleeding, postoperative complications and length of stay. Robotic surgery has a bright future in the treatment of pediatric common hepatic duct cysts and deserves to be promoted and popularized.
Impact of cooled compressed air and high-speed cutting on the drilling of hybrid composite-metal stacks
Authors: Devitte Cristiano , Souza André J. 
Published: September 2022

Abstract
Hybrid composite-metal stacks (HCMS) are used to manufacture and maintain aircraft combining metal alloys and composite materials. Drilling stands out due to its high use for installing rivets in fuselages. This work sought to identify the influence of cooled compressed air and high-speed cutting (HSC) on drilling multi-material joints with different configurations. Among the factors observed are the composite type (carbon- or glass-fiber-reinforced polymer), joint type with 2024 aluminum alloy (simple or composed), presence or absence of cooled air, cutting speed (40 and 220 m/min), and feed rate (0.02 and 0.08 mm/rev) in HCMS drilling. Adjusted delamination factor, hole wall roughness, hole roundness, and thrust force were evaluated. The combined effect between cutting speed and cooled air did not significantly impact the defects generated, making it possible to use HSC without harming the joint. Cooled air showed a tendency to decrease defects in HCMS drilling.
Adventive population of Trissolcus japonicus, parasitoid of Halyomorpha halys, discovered in southwestern Idaho
Authors: Richardson Kate V. , Alston Diane G. , Spears Lori R. 
Published: September 2022

Abstract
Adventive populations of Trissolcus japonicus (Ashmead) have been detected in eastern and western United States including the western states of Washington, Oregon, California, and Utah. These populations may provide classical biological control for the invasive stink bug Halyomorpha halys (Stål) which can cause severe damage and economic loss, especially to specialty crops in western North America. Idaho has previously been un-surveyed for the exotic T. japonicus and native parasitoids of H. halys. To assess the presence of stink bug parasitoids in Idaho, we deployed yellow sticky cards at nine sites in southwestern Idaho between June and October 2021. We discovered T. japonicus on sticky cards and emerging from wild H. halys egg masses. This is the first record of T. japonicus in the state of Idaho. Trissolcus japonicus constituted only 5% of Trissolcus species detected; other species included T. euschisti, T. hullensis, and T. utahensis. In other studies, native Trissolcus have been found to provide low parasitism rates of H. halys in invaded regions. Through genetic population level analysis, specimens from this study may suggest that T. japonicus is expanding inland from the West Coast, inhabiting ecozones previously considered unsuitable due to high temperatures and low humidity. These findings open the prospect of an effective biological control agent for H. halys in Idaho and potentially other hot and dry geographic regions and expands documentation of the presence of adventive T. japonicus populations in North America.