bluuebunny/crossref_metadata_2025_split huggingface dataset:
Citationchaser: A tool for transparent and efficient forward and backward citation chasing in systematic searching
Authors: Haddaway Neal R. , Grainger Matthew J. , Gray Charles T. 
Published: April 2022

AbstractSystematic searching aims to find all possibly relevant research from multiple sources, the basis for an unbiased and comprehensive evidence base. Along with bibliographic databases, systematic reviewers use a variety of additional methods to minimise procedural bias. Citation chasing exploits connections between research articles to identify relevant records for a review by making use of explicit mentions of one article within another. Citation chasing is a popular supplementary search method because it helps to build on the work of primary research and review authors. It does so by identifying potentially relevant studies that might otherwise not be retrieved by other search methods; for example, because they did not use the review authors' search terms in the specified combinations in their titles, abstracts, or keywords. Here, we briefly provide an overview of citation chasing as a method for systematic reviews. Furthermore, given the challenges and high resource requirements associated with citation chasing, the limited application of citation chasing in otherwise rigorous systematic reviews, and the potential benefit of identifying terminologically disconnected but semantically linked research studies, we have developed and describe a free and open source tool that allows for rapid forward and backward citation chasing. We introducecitationchaser, an R package and Shiny app for conducting forward and backward citation chasing from a starting set of articles. We describe the sources of data, the backend code functionality, and the user interface provided in the Shiny app.
Variables related to microwave heating‐toasting time and water migration assessment with kernel size approaches of specialty maize types
Authors: Lara Nelly , Osorio Fernando , Ruales Jenny 
Published: April 2022

AbstractBACKGROUNDThree main maize types with specialty kernels are used to make ready‐to‐eat maize by traditional toasting, and microwave toasting may be an innovative application. However, little is known of the toasting process of these Andean maize types. Therefore, the present study aimed to explore the behavior of a broad scope of variables in these maize types. The kernels were packed in sealed paper envelopes and subjected to six microwave heating‐toasting times from 0 to 390 s. Subsequently, with actual kernel size approaches, water content (WC), water ratio (WR), and water loss (WL) were analyzed.RESULTSIn addition to WC, WR, and WL, the surface area (S), volume (V), and geometric mean diameter (GMD) behaved like time‐related variables with a high correlation depending on the maize types and kernel dimensions. Thus, the WC, WR, and WL third‐order polynomial regression curves computed with the spatial (S/V)2 and distance (GMD/2)2 approaches indicated the water variation at each microwave heating‐toasting time with a clear difference among maize types a0, a1, and a2. Regarding their exchange profiles without and with the spatial (S/V)2 approach, the maximum rates showed significant differences between maize types and WC and WL. Likewise, the maximum rates displayed significant differences between the spatial (S/V)2 and distance (GMD/2)2 approaches, revealing a notable lack of consistency with the distance (GMD/2)2 approach.CONCLUSIONThe kernel size approaches revealed that water migration rates depended on differences in maize types. Such basic information represents the first insight into more physical‐based models of water diffusion during raw microwave maize heating‐toasting. © 2022 Society of Chemical Industry.
Psychological comorbidity: Predictors of residential treatment response among U.S. service members with posttraumatic stress disorder
Authors: Walter Kristen H. , McCabe Cameron T. , Watrous Jessica R. , Kohen Casey B. , Beltran Jessica L. , Kirk Alex , Campbell Justin S. 
Published: April 2022

AbstractResidential posttraumatic stress disorder (PTSD) research in military samples generally shows that in aggregate, PTSD symptoms significantly improve over the course of treatment but can remain at elevated levels following treatment. Identifying individuals who respond to residential treatment versus those who do not, including those who worsen, is critical given the extensive resources required for such programs. This study examined predictors of treatment response among 282 male service members who received treatment in a U.S. Department of Defense residential PTSD program. Using established criteria, service members were classified as improved, indeterminate (referent), or worsened in terms of self‐reported PTSD symptoms. Multinomial logistic regression results showed that for PTSD symptoms, higher levels of pretreatment PTSD symptom severity were associated with significantly lower odds of being in the improved group, adjusted odds ratio (aOR) = 0.955, p = .018. In addition, service members who completed treatment were significantly more likely to be in the improved group, aOR = 2.488, p = .048. Longer average pretreatment nightly sleep duration, aOR = 1.157, p = .035, and more severe pretreatment depressive symptoms, aOR = 1.109, p = .014, were associated with significantly higher odds of being in the improved group. These findings reveal clinical characteristics better suited for residential PTSD treatment and highlight implications for comorbid conditions.
Designing Double‐Layer Multimaterial Composite Patch Scaffold with Adhesion Resistance for Hernia Repair
Authors: Hu Qingxi , Wu Junjie , Zhang Haiguang , Dong Wenpei , Gu Yan , Liu Suihong 
Published: April 2022

AbstractHernia repair mesh is associated with a number of complications, including adhesions and limited mobility, due to insufficient mechanical strength and nonresorbability. Among them, visceral adhesions are one of the most serious complications of patch repair. In this study, a degradable patch with an antiadhesive layer is prepared for hernia repair by 3D printing and electrospinning techniques using polycaprolactone, polyvinyl alcohol, and soybean peptide (SP). The study into the physicochemical properties of the patch is found that it has adequate mechanical strength requirements (16 N cm−1) and large elongation at break, which are superior than commercial polypropylene patches. In vivo and in vitro experiments show that human umbilical vein endothelial cells proliferated well on composite patches, and showed excellent biocompatibility with the host and little adhesion through a rat abdominal wall defect model. In conclusion, the results of this study show that composite patch can effectively reduce the occurrence of adhesions, while the addition of SP in the patch further enhances its biocompatibility. It is believed that a regenerative biological patch with great potential in hernia repair provides a new strategy for the development of new biomimetic biodegradable patches.
Combined inhibition of BET bromodomain and mTORC1/2 provides therapeutic advantage for rhabdomyosarcoma by switching cell death mechanism
Authors: Srivastava Ritesh K. , Guroji Purushotham , Jin Lin , Mukhtar M. Shahid , Athar Mohammad 
Published: April 2022

AbstractAberrant activation of multiple complex signaling pathways underlies the pathogenesis of rhabdomyosarcoma (RMS), which remains a cause of mortality in approximately 30% of children with RMS. Bromodomain and extraterminal (BET) domain chromatin remodeling regulates several of these pathways. Here, we targeted bromodomain 4 (BRD4) in combination with another molecular metabolic tumor driver, the Akt/mTOR signaling pathway, to provide a highly effective treatment for this neoplasm. We demonstrated that a nexus of these two molecular pathways underlies RMS pathogenesis. Our data show that the combined inhibition of the BET bromodomain and mTORC1/2 signaling abrogates aggressive RMS growth. Thus, the bromodomain inhibitor RVX‐208 significantly augmented the therapeutic effects of the dual mTORC1/2 inhibitors, OSI‐027 and PP242, both in vitro and in a human xenograft murine model. Drug‐treated residual tumors showed a decrease in the activation of underlying signaling mechanisms characterized by a reduction in the expression of p‐AKT, p‐mTOR, p‐p70S6K, cyclin D1, and proliferation. Our ChIP‐seq data demonstrated that RVX‐208 effectively blocked BRD4 occupancy on its target promoters. ChIP‐qPCR assays further confirmed that RVX‐208 treatment resulted in a significant decrease in H3K27ac and H4K8ac signals at their target loci. While single RVX‐208 treatment induces apoptosis and a single mTORC1/2 inhibitor induces macropinocytosis, their combined treatment led to necroptosis‐mediated cell death. These data suggest that combined treatment with drugs targeting BRD4 and mTORC1/2 may be an effective therapeutic intervention for drug‐resistant RMS.
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
Authors: Fakih Walaa , Zeitoun Ralph , AlZaim Ibrahim , Eid Ali H. , Kobeissy Firas , Abd‐Elrahman Khaled S. , El‐Yazbi Ahmed F. 
Published: April 2022

AbstractThe metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high‐density lipoprotein cholesterol levels, and hypertension, in addition to central obesity. The syndrome confers a high risk of cardiovascular mortality. Indeed, metabolic dysfunction has been shown to cause a direct insult to smooth muscle and endothelial components of the vasculature, which leads to vascular dysfunction and hyperreactivity. This, in turn, causes cerebral vasoconstriction and hypoperfusion, eventually contributing to cognitive deficits. Moreover, the metabolic syndrome disrupts key homeostatic processes in the brain, including apoptosis, autophagy, and neurogenesis. Impairment of such processes in the context of metabolic dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer, Parkinson, and Huntington diseases.The aim of this review is to elucidate the role that the metabolic syndrome plays in the pathogenesis of the latter disorders, with a focus on the role of perivascular adipose inflammation in the peripheral‐to‐central transduction of the inflammatory insult. This review delineates common signaling pathways that contribute to these pathologies. Moreover, the role of therapeutic agents aimed at treating the metabolic syndrome, as well as their risk factors that interfere with the aforementioned pathways, are discussed as potential interventions for neurodegenerative diseases.
Impact of weight loss with diet or diet plus physical activity on cardiac magnetic resonance imaging and cardiovascular disease risk factors: Heart Health Study randomized trial
Authors: Jakicic John M. , Rogers Renee J. , Lang Wei , Gibbs Bethany B. , Yuan Nalingna , Fridman Yaron , Schelbert Erik B. 
Published: April 2022

AbstractObjectiveThe primary aim of this study was to examine the change in left ventricular mass (LVM) in adults with overweight or obesity in response to a behavioral weight‐loss intervention, with variable physical activity (PA) prescriptions.MethodsA total of 383 adults were randomized to a 12‐month intervention of diet modification (DIET), DIET plus 150 min/wk of PA (DIET+MODPA), or DIET plus prescription of 250 min/wk of PA (DIET+HIGHPA). LVM was measured with cardiac magnetic resonance imaging.ResultsTwelve‐month weight loss was −10.2% (95% CI: −11.7% to −8.8%) in the DIET group, −11.0% (95% CI: −12.4% to −9.5%) in the DIET+MODPA group, and −10.3% (95% CI: −11.8% to −8.9%) in the DIET+HIGHPA group. LVM decreased at 12 months in the DIET group (−2.9 g [95% CI: −5.2 to −0.7]; p = 0.0114), with no change observed in the DIET+MODPA group (−0.8 g [95% CI: −3.0 to 1.5]; p = 0.4979) or the DIET+HIGHPA group (−1.1 g [95% CI: −3.3 to 1.1]; p = 0.3299).ConclusionsWeight loss through dietary modification resulted in reduced LVM, whereas, when combined with at least 150 min/wk of prescribed moderate‐to‐vigorous PA, LVM was preserved. These may both be favorable adaptations to weight loss and PA in adults with overweight or obesity that warrant further investigation to understand the clinical implications of these changes on cardiovascular disease risk.
Racial/ethnic disparities in childhood obesity: The role of school segregation
Authors: Mahmood Nuha , Sanchez‐Vaznaugh Emma V. , Matsuzaki Mika , Sánchez Brisa N. 
Published: April 2022

AbstractObjectiveRecent studies have observed that racial or ethnic adult health disparities revealed in national data dissipate in racially integrated communities, supporting the theory that “place, not race” shapes the nature and magnitude of racial/ethnic health disparities. This study tested this theory among children.MethodsIn 2020, the racial/ethnic childhood obesity disparities within integrated schools and between segregated schools were estimated using statewide cross‐sectional data collected in 2019 on fifth, seventh, and ninth grade students from California public schools.ResultsSchool segregation accounted for a large part of the obesity disparities between White children and children of color (Latino, Black, and Filipino children). In racially integrated schools, obesity disparities were much smaller than those in statewide data, whereas racial or ethnic childhood obesity disparities were larger when comparing children in majority‐White schools with those attending schools with a majority enrollment of children of color, except for Asian children, who generally had lower obesity rates than their White peers.ConclusionsSchool‐level racial segregation is a salient contributor to racial/ethnic childhood obesity disparities. Reducing obesity disparities may be particularly effective if place‐level interventions target socioeconomically disadvantaged integrated schools and segregated schools attended primarily by children of color.
Robust fusion filter for multisensor descriptor system with uncertain‐variance noises and packet dropout
Authors: Liu Wentao , Zheng Jiayi , Dou Yinfeng , Ran Chenjian 
Published: April 2022

AbstractFor the multisensor linear stochastic descriptor system with uncertain‐variance noises and packet dropout, the standard state space model of the new reduced‐order augmented state is obtained based on the singular value decomposition (SVD) approach and augmented state approach. By applying the min‐max robust estimation principle and Kalman filtering theory, the local robust time‐varying Kalman filters of the reduced‐order augmented state and fictitious process noise are proposed. Then, the local robust time‐varying filters of the original descriptor system are presented according to the relation of the reduced‐order augmented state and the original state. And the distributed and covariance intersection (CI) fusion robust time‐varying filters are presented, and the actual and conservative filtering error variances are obtained. Further, the robustness of the local and fused robust filters are proved by applying Lyapunov equation approach, and the accuracy relation between them is analyzed. A simulation example applied to a circuit system shows its effectiveness and applicability.
Comparative evaluation of areca/carbon/basalt fiber reinforced epoxy/bio epoxy based hybrid composites
Authors: Yashas Gowda T. G. , Madhu P. , Kushvaha Vinod , Rangappa Sanjay Mavinkere , Siengchin Suchart 
Published: April 2022

AbstractThe use of renewable resources to reduce environmental effects can provide a long‐term platform. The natural fiber is an excellent renewable resource for developing lightweight composite materials. The present work is the development of hybrid areca/carbon/basalt reinforced epoxy/bio epoxy composites and the investigation of their mechanical, thermal, and water absorption behavior. Four layered areca–carbon, areca–basalt, and areca fiber reinforced epoxy/bio epoxy composites were fabricated with three different varying stacking sequences with epoxy and bio epoxy composites with a hand layup method. The Mechanical properties like tensile, flexural, and impact behavior were evaluated and compared between the synthetic and bio epoxy resin. Also, the thermal, water absorption, and morphological studies of all composites were studied, and results showed that out of all the composites the carbon—areca fiber reinforced composites showed better mechanical properties and SEM analysis exemplified the better bonding between areca, carbon, and basalt fabrics. The prepared laminates can be used for developing some commercial medium‐load structural applications.
Untreated and chemically treated Pennisetum orientale grass fiber filled vinyl ester composites: Physical, mechanical, and thermal properties analysis
Authors: Nayak Subhakanta 
Published: April 2022

AbstractThe utilization of natural fibers rather than engineered filaments has turned into a subject of conversation in the composite industries. In this research, one of the natural fibers was synthesized from Pennisetum orientale grass and the surfaces were modified using sodium hydroxide (NaOH) chemically. Then they were used as reinforcement in vinyl ester polymer by different weight percentage (0, 5, 10, 15, 20, 25, and 30 wt%) for fabrication of composites. At different filler loading various mechanical properties were evaluated and discussed. The mechanical properties of the composites were observed to increase at beginning phase with increase in filler content till optimum (25 wt%) fiber loading and from there on declines. The composite at optimum fiber loading were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, thermogravimetric analysis and compared with untreated composites. The findings give manufactures and engineer a general idea to use this composite for weight reduction especially in automotive applications.
Green engineered rubber process oil for passenger tire tread component and its effect on mechanical and rheological characteristics
Authors: Kumarasamy Ariyanayagam , Narayanasamy Babu , Arumugam Elango 
Published: April 2022

AbstractThe rich flavonoid glycosides present in the peel of lemon has the property of anticarcinogen the need of hour. This experimental study open up way for exploring the possibilities of providing an optimal alternative in search of conventional high polycyclic aromatic hydrocarbon rubber process oils. The preliminary elastomer science test (tensile, hardness, and rheometry) conducted provided scope for replacement. The tensile test showed higher strength at minimal loading (10 phr) in comparison with controlling component aromatic oil. The hardness test exposed a gradual 3% increase for increase in loading. The elongation at break was found higher for L ‐ trials (L1‐Lemon peel oil 5 phr, L2–10, L3–15 and L4–20 phr) than A‐ trials (Controlling component aromatic oil) indicates greater resistance to change in geometric property without any crack formation attributed to uniform dispersion of N330. Around 2% of mass loss (mg) and 6% of volumetric loss were prevented with the usage of trial ‐L process oil in place of trial A process oil. The uniformity in dispersion was evident from SEM images prove to be an optimal alternative to high polycyclic aromatic hydrocarbon rubber process oil a major carcinogenic threat to environment and living creatures.
Power conversion efficiency of 25.26% for silicon heterojunction solar cell with transition metal element doped indium oxide transparent conductive film as front electrode
Authors: Dong Gangqiang , Sang Jiacheng , Peng Chen‐Wei , Liu Fengzhen , Zhou Yurong , Yu Cao 
Published: April 2022

AbstractIn this paper, to improve the power conversion efficiency (Eff) of silicon heterojunction (SHJ) solar cells, we developed the indium oxide doped with transition metal elements (IMO) as front transparent conductive oxide (TCO) layer combined with microcrystalline silicon (μ‐Si:H(n+)) for SHJ solar cell. The optical and electrical properties as well as structures of hydrogenated IMO (IMO:H) films were studied and compared to conventional indium tin oxide (ITO) film. Such IMO:H films have high carrier mobility over 70 cm2/V·s, high transmittance, and low free carrier absorption, which leads to a high short circuit current density exceeding 40 mA/cm2. In addition, the low sheet resistance and contact resistivity of the IMO:H films contribute to the high fill factor of the solar cell. The average Eff of solar cells with IMO:H + μ‐Si:H(n+) is improved by 0.4% compared with that of the solar cells with ITO + a‐Si:H(n+). Finally, a certified efficiency up to 25.26% (total area, 274.5 cm2) was achieved.
The efficacy of exergaming in patients with knee osteoarthritis: A randomized controlled clinical trial
Authors: Mete Emel , Sari Zübeyir 
Published: April 2022

AbstractBackgroundExergaming, one of the most recognized virtual rehabilitation tools, has been shown to be useful for promoting physical activity and enhancing postural stability for neurologic conditions. However, studies with exergaming programs for patients with knee osteoarthritis (OA) are limited.AimsWe aimed to investigate the effects of exergaming given by visual and auditory stimulated assisted joint training device in addition to the conventional physiotherapy program on pain intensity, range of motion (ROM), functional status, kinesiophobia, proprioceptive acuity, muscle strength, and postural stability in patients with knee OA.Study DesignRandomized controlled clinical trial.MethodsSixty patients (47 female, 13 male) with knee osteoarhritis aged 40–65 years (57.36 ± 7.26) who were at stage of two to three according to the Kellegren Lawrence radiological evaluation were included in the study. The patients were randomly divided into two groups as study group (conventional physiotherapy + exergaming) and control group (conventional physiotherapy). Electrotherapy and exercise program were applied to both of the groups along 5 days a week for 6 weeks but exergaming only applied to study group. ROM, pain intensity, proprioceptive acuity, kinesiophobia, muscle strength, and postural stability of the patients were evaluated at the beginning and end of the treatment.ResultsIn the intra‐group analyses of all the assessments of the patients, there was a significant difference in the positive direction in both groups, except for the postural stability values. In the intra‐group analyses of postural stability, there was a significant increase only in the study group. In comparison between the groups, proprioceptive acuity, ROM, functional status, and postural stability scores were significantly increased in the study group according to the control group; pain and kinesiophobia decreased significantly.ConclusionIn this study, the exergaming accompanied with conventional physiotherapy programs resulted more positive improvements on pain, ROM, postural stability, kinesiophobia, proprioceptive acuity, and functional status in patients with knee OA compared to the conventional physiotherapy program alone.