bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Usability of Voice Assistant-Based CBT for Age-Related Depression
Authors: Striegl Julian , Gotthardt Marie , Loitsch Claudia , Weber Gerhard 
Published: July 2022

AbstractTo combat the global shortage of mental health services, new solutions - such as computerized therapy options - have to be found. While research in this field has been ongoing for several decades and approaches such as chatbot-based cognitive behavioral therapy (CBT) have already shown to be effective in reducing symptoms of depression for younger adults, voice assistant-based (VA-based) approaches have thus far not been investigated deeply. However, especially for elderly people with depression VA-based systems could yield benefits - such as the avoidance of physical accessibility issues. Therefore, we propose the design of a VA-based system capable of delivering selected methods from CBT to elderly users with depression in order to investigate its usability. To assess the usability of the conceptualized system in comparison to a chatbot-based approach we conducted a randomized controlled A/B testing experiment with 14 participants. Results indicate a good usability and acceptance of the designed system and a preference for the delivery of CBT-methods via voice assistant rather than via chatbot, especially among elderly participants.
Making Person-Centred Health Care Beneficial for People with Mild Cognitive Impairment (MCI) or Mild Dementia – Results of Interviews with Patients and Their Informal Caregivers
Authors: Gappa Henrike , Mohamad Yehya , Breidenbach Martin , Abizanda Pedro , Schmidt-Barzynski Wolfgang , Steinhoff Antje , Robbins Timothy , Randeva Harpal , Kyrou Ioannis , Cramariuc Oana , Ciobanu Cristiana , Arvanitis Theodoros N. , Keung Sarah N. Lim Choi , Ertürkmen Gokce Banu Laleci , Gencturk Mert , Yüksel Mustafa , Ayadi Jaouhar , Gilardi Luca , Consoli Angelo , Ferrazzini Lionello , Velasco Carlos A. 
Published: July 2022

AbstractIn the health care sector, person-centred treatment approaches have shown the potential to improve treatment outcomes and quality of life of patients. In particular, this applies where patients are living with complex conditions like multimorbid older patients with Mild Cognitive Impairment (MCI) or mild dementia. Such treatment approaches quite often include input from modern health technologies like health/home monitoring platforms which also offer services to patients for self-management of their conditions. This approach is also followed in the research project CAREPATH (An Integrated Solution for Sustainable Care for Multimorbid Patients with Dementia). To achieve acceptance of such complex health technologies, their services must be beneficial in the eyes of target end users which included in the case of CAREPATH, the patient’s informal caregivers. Therefore, understanding the user requirements of patients and their informal caregivers is of utmost importance which was achieved in CAREPATH by interviews. These revealed that patients’ preferences in regard to what services and information shall be provided to them shall be limited to what they deem necessary which is highly personal. Informal caregivers as opposed to patients, are much interested in receiving most possible information about their care-dependent’s health status. Thus, provision of services and information for these user groups need to be highly customizable to their personal preferences and needs.
Displaced neutrino jets at the LHeC
Authors: Cottin Giovanna , Fischer Oliver , Mandal Sanjoy , Mitra Manimala , Padhan Rojalin 
Published: July 2022

Abstract
Extending the Standard Model with right-handed neutrinos (RHNs) is well motivated by the observation of neutrino oscillations. In the type-I seesaw model, the RHNs interact with the SM particles via tiny mixings with the active neutrinos, which makes their discovery in the laboratory, and in particular at collider experiments in general challenging. In this work we instead consider an extension of the seesaw model with RHNs with the addition of a leptoquark (LQ), and employ a non-minimal production mechanism of the RHN via LQ decay, which is unsuppressed by neutrino mixing. We focus on relatively light RHN with mass $$ \mathcal{O} $$
O
(10) GeV and LQ with mass 1.0 TeV, and explore the discovery prospect of the RHN at the proposed Large Hadron electron Collider. In the considered mass range and with the given interaction strength, the RHN is long lived and, due to it stemming from the LQ decay, it is also heavily boosted, resulting in collimated decay products. The unique signature under investigation is thus a displaced fat jet. We use kinematic variables to separate signal from background, and demonstrate that the ratio variables with respect to energy/number of displaced and prompt tracks are useful handles in the identification of displaced decays of the RHN. We also show that employing a positron beam provides order of magnitude enhancement in the detection prospect of this signature.
Meilen- und Grenzsteine der Entwicklung
Authors: Jenni Oskar 
Published: July 2022

ZusammenfassungUmfassende Kenntnisse über Meilen- und Grenzsteine der kindlichen Entwicklung sind für Kinderärztinnen und Kinderärzte unerlässlich. Ein Meilenstein definiert den Zeitpunkt, an dem ein bestimmter Entwicklungsschritt zum ersten Mal von einem Kind vollzogen wurde. Von diesem individuellen Meilenstein abzugrenzen ist der Grenzstein: Er kennzeichnet denjenigen Zeitpunkt, an dem fast alle Kinder (z. B. 90 %) einen bestimmten Entwicklungsschritt erreicht haben. Grenzsteine stellen – ebenso wie Meilensteine – keine qualitativen Aspekte der Entwicklung dar; sie beschreiben nicht die individuellen Entwicklungswege und Entwicklungsvarianten der Kinder, sondern definieren ein bestimmtes Alter, in dem die Mehrheit der Kinder ein vorgegebenes Entwicklungsziel erreicht hat. Grenzsteine sind eine Art Frühwarnsystem und geben Hinweise darauf, dass eine weitere diagnostische Abklärung erfolgen sollte.
Depth estimation from a single SEM image using pixel-wise fine-tuning with multimodal data
Authors: Houben Tim , Huisman Thomas , Pisarenco Maxim , van der Sommen Fons , de With Peter H. N. 
Published: July 2022

AbstractTo support the ongoing size reduction in integrated circuits, the need for accurate depth measurements of on-chip structures becomes increasingly important. Unfortunately, present metrology tools do not offer a practical solution. In the semiconductor industry, critical dimension scanning electron microscopes (CD-SEMs) are predominantly used for 2D imaging at a local scale. The main objective of this work is to investigate whether sufficient 3D information is present in a single SEM image for accurate surface reconstruction of the device topology. In this work, we present a method that is able to produce depth maps from synthetic and experimental SEM images. We demonstrate that the proposed neural network architecture, together with a tailored training procedure, leads to accurate depth predictions. The training procedure includes a weakly supervised domain adaptation step, which is further referred to as pixel-wise fine-tuning. This step employs scatterometry data to address the ground-truth scarcity problem. We have tested this method first on a synthetic contact hole dataset, where a mean relative error smaller than 6.2% is achieved at realistic noise levels. Additionally, it is shown that this method is well suited for other important semiconductor metrics, such as top critical dimension (CD), bottom CD and sidewall angle. To the extent of our knowledge, we are the first to achieve accurate depth estimation results on real experimental data, by combining data from SEM and scatterometry measurements. An experiment on a dense line space dataset yields a mean relative error smaller than 1%.
Everlasting UC Commitments from Fully Malicious PUFs
Authors: Magri Bernardo , Malavolta Giulio , Schröder Dominique , Unruh Dominique 
Published: July 2022

AbstractEverlasting security models the setting where hardness assumptions hold during the execution of a protocol but may get broken in the future. Due to the strength of this adversarial model, achieving any meaningful security guarantees for composable protocols is impossible without relying on hardware assumptions (Müller-Quade and Unruh, JoC’10). For this reason, a rich line of research has tried to leverage physical assumptions to construct well-known everlasting cryptographic primitives, such as commitment schemes. The only known everlastingly UC secure commitment scheme, due to Müller-Quade and Unruh (JoC’10), assumes honestly generated hardware tokens. The authors leave the possibility of constructing everlastingly UC secure commitments from malicious hardware tokens as an open problem. Goyal et al. (Crypto’10) constructs unconditionally UC-secure commitments and secure computation from malicious hardware tokens, with the caveat that the honest tokens must encapsulate other tokens. This extra restriction rules out interesting classes of hardware tokens, such as physically uncloneable functions (PUFs). In this work, we present the first construction of an everlastingly UC-secure commitment scheme in the fully malicious token modelwithout requiringhonest token encapsulation. Our scheme assumes the existence of PUFs and is secure in the common reference string model. We also show that our results are tight by giving an impossibility proof for everlasting UC-securecomputationfrom non-erasable tokens (such as PUFs), even with trusted setup.
No evidence in support of arthroscopic partial meniscectomy in adults with degenerative and nonobstructive meniscal symptoms: a level I evidence-based systematic review
Authors: Migliorini Filippo , Oliva Francesco , Eschweiler Jörg , Cuozzo Francesco , Hildebrand Frank , Maffulli Nicola 
Published: July 2022

AbstractPurposeIt is unclear whether the results of arthroscopic partial meniscectomy (APM) are comparable to a structured physical therapy (PT). This systematic review investigated efficacy of APM in the management of symptomatic meniscal damages in middle aged patients. Current available randomised controlled trials (RCTs) which compared APM performed in isolation or combined with physical therapy versus sham arthroscopy or isolated physical therapy were considered in the present systematic review.MethodsThis systematic review was conducted according to the 2020 PRISMA statement. All the level I RCTs which investigated the efficacy of AMP were accessed. Studies which included elderlies with severe OA were not eligible, nor were those in which APM was combined with other surgical intervention or in patients with unstable knee or with ligaments insufficiency. The risk of bias was assessed using the software Review Manager 5.3 (The Nordic Cochrane Collaboration, Copenhagen). To rate the quality of evidence of collected outcomes, the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used.ResultsData from 17 studies (2037 patients) were collected. 48.5% (988 of 2037 patients) were women. The mean age of the patients was 52.7 ± 3.9 years, the mean BMI 27.0 ± 1.3 kg/m2. The current evidence suggests no difference in functional PROMs (quality of the evidence: high), clinical PROMs (quality of the evidence: high), pain (quality of the evidence: high), quality of life (quality of the evidence: high), physical performance measures (quality of the evidence: moderate), and OA progression (quality of the evidence: moderate).ConclusionsThe benefits of APM in adults with degenerative and nonobstructive meniscal symptoms are limited. The current evidence reports similarity in the outcome between APM and PT. Further long-term RCTs are required to investigate whether APM and PT produce comparable results using validated and reliable PROMs. Moreover, future RCTs should investigate whether patients who might benefit from APM exist, clarifying proper indications and outcomes. High quality investigations are strongly required to establish the optimal PT regimes.Level of evidenceLevel I.
Fatal adverse events of rivaroxaban combined with aspirin: an analysis using data from VigiBase
Authors: Zhang Qingxia , Ding Qian , Yan Suying , Yue Qun-Ying 
Published: July 2022

Abstract
Purpose
The aim of this study was to analyze the clinical characteristics of fatal adverse events (AEs) of rivaroxaban combined with aspirin and to underline the importance of the rational use of drugs.

Methods
The WHO global database of reported potential side effects of medicinal products (VigiBase) was searched for fatal AEs in the combined use of rivaroxaban and aspirin, and the clinical characteristics of those cases with sufficient information (vigiGrade completeness score ≥ 0.80) were analyzed.

Results
By January 19, 2020, 2309 fatal adverse event reports of rivaroxaban combined with aspirin from 21 countries were entered in VigiBase. One hundred and twenty cases contained further information, of which 42 were female (35%) and 78 were male (65%). The median age was 75 (range 34 to 93) years, and 109 cases (91%) were elderly patients (≥ 65 years). The AEs listed in the fatal case reports included bleeding in 114 cases (mainly intracranial hemorrhage and gastrointestinal hemorrhage, 59 and 46 respectively, accounting for 88%) and ischemic events in six cases (ischemic stroke in three, acute myocardial infarction in two, myocardial infarction combined with acute liver failure in one). Among the patients with bleeding events, 108 (95%) had existing risk factors for bleeding or for interacting with aspirin or rivaroxaban. These may be divided into the following: diseases (hypertension, renal impairment, history of stroke, peptic ulcer, or previous bleeding), drugs (high dose aspirin, antiplatelet drugs, anticoagulants, P-gp inhibitors/CYP3A4 inhibitors, non-steroidal anti-inflammatory drugs, steroids, and selective serotonin reuptake inhibitors), or other factors (e.g., elderly, low body weight, or excessive intake of ginger, fish oil, or alcohol). There were 45 cases with two or more of these risk factors in addition to rivaroxaban and aspirin. Patients with ischemic events are often in very high-risk groups of atherosclerotic cardiovascular disease (ASCVD) or self-discontinuation of treated drugs. Medication errors occurred in 24 patients (20%): excessive treatment in 17 cases, contraindication in three, frequency error in two, excessive treatment combined with contraindication in one, and self-discontinuation in one.

Conclusions
Fatal AEs related to rivaroxaban combined with aspirin, including bleeding and ischemic events, have been reported mostly in the elderly, and sometimes involved medication errors. The fatal AEs mainly manifested as serious bleeding, and most of them occurred in patients with concurrent multiple risk factors. Monitoring coagulation during rivaroxaban treatment is recommended in very high-risk ASCVD populations, and attention should be paid to prevention of medication errors.
Enhancement and investigation of biodegradability of poly (methyl methacrylate) and poly (vinyl chloride) by blending with biodegradable polymer
Authors: Sudhakar Yethadka Narahari , Selvakumar Muthu , Bhat Denthaje Krishna 
Published: July 2022

AbstractPresently, society needs an eco-friendlier alternative for non-biodegradable polymers, nonetheless, synthetic polymers have established the market because of cost and easy to manufacture. To address the challenge of reducing the lifetime of degradation of these polymers, the scope of blending natural biopolymers is effective. This paper focuses on confirming the effectiveness of biodegradation in the molecular level of polymer blends between synthetic polymers and biopolymers. The synthetic polymers such as poly (methyl methacrylate) (PMMA) and poly (vinyl chloride) (PVC) were blended with varying compositions of biodegradable cellulose acetate butyrate (CAB). Using dimethylformamide (DMF) the films of PMMA/CAB, PVC/CAB blends were prepared by the solution casting method. Four different methods for studying biodegradability of these blends, namely soil burial test, enzymatic degradation, activated sludge degradation followed by microbial degradation were performed. The confirmation of degradation was done by NMR, FTIR, and Gel Permeation Chromatography (GPC) studies. Moreover, degradation analyses were determined by the weight loss method. Sufficient biodegradability was shown with an increase in CAB content in the blend. This work provides an approach for bringing about the degradation of synthetic polymers without much compromise on their properties. Also, the type of microorganisms that effectively degrades these polymer bends can be known.
The vacuolar morphology protein VAC14 plays an important role in sexual development in the filamentous ascomycete Sordaria macrospora
Authors: Groth Anika , Ahlmann Svenja , Werner Antonia , Pöggeler Stefanie 
Published: July 2022

AbstractThe multiprotein Fab1p/PIKfyve-complex regulating the abundance of the phospholipid phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is highly conserved among eukaryotes. In yeast/mammals, it is composed of the phosphatidylinositol 3-phosphate 5-kinase Fab1p/PIKfyve, the PtdIns(3,5)P2 phosphatase Fig4p/Sac3 and the scaffolding subunit Vac14p/ArPIKfyve. The complex is located to vacuolar membranes in yeast and to endosomal membranes in mammals, where it controls the synthesis and turnover of PtdIns(3,5)P2. In this study, we analyzed the role and function of the Fab1p/PIKfyve-complex scaffold protein SmVAC14 in the filamentous ascomycete Sordaria macrospora (Sm). We generated the Smvac14 deletion strain ∆vac14 and performed phenotypic analysis of the mutant. Furthermore, we conducted fluorescence microscopic localization studies of fluorescently labeled SmVAC14 with vacuolar and late endosomal marker proteins. Our results revealed that SmVAC14 is important for maintaining vacuolar size and appearance as well as proper sexual development in S. macrospora. In addition, SmVAC14 plays an important role in starvation stress response. Accordingly, our results propose that the turnover of PtdIns(3,5)P2 is of great significance for developmental processes in filamentous fungi.
Association between ultra-processed food consumption and cognitive performance in US older adults: a cross-sectional analysis of the NHANES 2011–2014
Authors: R Cardoso Barbara , Machado Priscila , Steele Euridice Martinez 
Published: July 2022

Abstract
Purpose
This study evaluated the association between ultra-processed food (UPF) consumption and cognitive performance among older US adults.

Methods
This cross-sectional study assessed 3632 participants aged 60+ years from the National Health and Nutrition Examination Survey (NHANES) 2011–14. Cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Word Learning test, Animal Fluency test, and the Digit Symbol Substitution test (DSST). Dietary intake was assessed using two 24-h diet recalls. Food items were classified according to the NOVA system, a classification based on the nature, extent, and purpose of industrial food processing. Linear regression models were used to evaluate the association of dietary share of UPF (% of daily energy intake) (categorized as tertiles) and cognitive test scores, adjusting for socio-demographic variables, physical activity, smoking status, and chronic diseases (cardiovascular diseases, diabetes, and depression). Models excluding participants with pre-existing diseases were carried out to address potential reverse causality.

Results
On average, UPF accounted for 53% of total energy intake, ranging from 33 to 70% across extreme tertiles. Inverted U-shape association between UPF consumption and Animal fluency and DSST was observed. No significant associations were observed between the UPF intake tertiles and the cognitive test results. Nonetheless, UPF consumption was significantly associated with worse performance in Animal Fluency in older adults without pre-existing diseases (P < 0.05).

Conclusion
UPF consumption was associated with worse performance in Animal Fluency among older people without pre-existing diseases. Decreasing UPF consumption may be a way to improve impaired cognition among older adults.
Utility of the Heat Index in defining the upper limits of thermal balance during light physical activity (PSU HEAT Project)
Authors: Vecellio Daniel J. , Wolf S. Tony , Cottle Rachel M. , Kenney W. Larry 
Published: July 2022

AbstractExtreme heat events and consequent detrimental heat-health outcomes have been increasing in recent decades and are expected to continue with future climate warming. While many indices have been created to quantify the combined atmospheric contributions to heat, few have been validated to determine how index-defined heat conditions impact human health. However, this subset of indices is likely not valid for all situations and populations nor easily understood and interpreted by health officials and the public. In this study, we compare the ability of thresholds determined from the National Weather Service’s (NWS) Heat Index (HI), the Wet Bulb Globe Temperature (WBGT), and the Universal Thermal Climate Index (UTCI) to predict the compensability of human heat stress (upper limits of heat balance) measured as part of the Pennsylvania State University’s Heat Environmental Age Thresholds (PSU HEAT) project. While the WBGT performed the best of the three indices for both minimal activities of daily living (MinAct; 83 W·m−2) and light ambulation (LightAmb; 133 W·m−2) in a cohort of young, healthy subjects, HI was likewise accurate in predicting heat stress compensability in MinAct conditions. HI was significantly correlated with subjects’ perception of temperature and humidity as well as their body core temperature, linking perception of the ambient environment with physiological responses in MinAct conditions. Given the familiarity the public has with HI, it may be better utilized in the expansion of safeguard policies and the issuance of heat warnings during extreme heat events, especially when access to engineered cooling strategies is unavailable.
Subdifferential set of an operator
Authors: K. Rao T. S. S. R. 
Published: July 2022

AbstractLet X, Y be complex Banach spaces. Let $${\mathcal L}(X,Y)$$

L
(
X
,
Y
)

be the space of bounded operators. An important aspect of understanding differentiability is to study the subdifferential of the norm at a point, say $$x \in X$$

x
∈
X

, this is the set, $$\{f \in X^*:\Vert f\Vert =1~,f(x)=\Vert x\Vert \}$$

{
f
∈

X
∗

:
‖
f
‖
=
1

,
f

(
x
)

=
‖
x
‖
}

. See page 7 in Deville et al. (Pitman Monographs and Surveys in Pure and Applied Mathematics. 64. Harlow: Longman Scientific and Technical. New York: John Wiley and Sons, Inc. 1993). Motivated by recent results of Singla (Singla in Linear Alg. Appl. 629:208–218, 2021) in the context of Hilbert spaces, for $$T \in {{\mathcal {L}}}(X,Y)$$

T
∈
L
(
X
,
Y
)

, we determine the subdifferential of the operator norm at T, $$\partial _T = \{\Lambda \in {{\mathcal {L}}}(X,Y)^*: \Lambda (T) = \Vert T\Vert ~,~\Vert \Lambda \Vert =1\}$$

∂
T

=
{
Λ
∈
L

(
X
,
Y
)

∗

:
Λ

(
T
)

=
‖
T
‖

,

‖
Λ
‖
=
1
}

. Our approach is based on the ‘position’ of the space of compact operators and the Calkin norm of T. Our ideas give a unified approach and extend several results from Singla (Linear Alg. Appl. 629:208–218, 2021) to the case of $$\ell ^p$$

ℓ
p

-spaces for $$1<p<\infty $$

1
<
p
<
∞

. We also investigate the converse, using the structure of the subdifferential set to decide when the Calkin norm is a strict contraction. As an application of these ideas, we partially solve the open problem of relating the subdifferential of the operator norm at a compact operator T to that of $$T(x_0)$$

T
(

x
0

)

, where $$x_0$$

x
0

is a unit vector where T attains its norm.