bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of university students spending time with young people with autism
Authors: Sari Hatice Yildirim , Dereli Feyza , Akgul Esra Ardahan 
Published: July 2022

Aims:This study aimed to clarify the experiences of university students following their participation in a project where they spent time with young people with autism.Methods:Students at İzmir Kâtip Çelebi University, Turkey, volunteered to take part in a project where they met and socialised with young people with autism. At the end of the project, focus group interviews were held with the students.Findings:In the descriptive analysis, themes such as prejudice, anxiety and fear, benefit, lack of knowledge, friendship, normality and experience were determined. The students stated that the participants with autism and their parents, as well as themselves, benefited from the project.Conclusion:After completing the project, the university students stated that they were able to get acquainted with and effectively socialise with children with autism and that this experience was beneficial to them.
Impact of capsular preservation on patient-reported outcomes and complication rates in total hip arthroplasty using the direct anterior approach
Authors: Stadelmann Vincent A. , Rüdiger Hannes A. , Nauer Selina , Leunig Michael 
Published: July 2022

Aims It is not known whether preservation of the capsule of the hip positively affects patient-reported outcome measures (PROMs) in total hip arthroplasty using the direct anterior approach (DAA-THA). A recent randomized controlled trial found no clinically significant difference at one year postoperatively. This study aimed to determine whether preservation of the anterolateral capsule and anatomical closure improve the outcome and revision rate, when compared with resection of the anterolateral capsule, at two years postoperatively. Methods Two consecutive groups of patients whose operations were performed by the senior author were compared. The anterolateral capsule was resected in the first group of 430 patients between January 2012 and December 2014, and preserved and anatomically closed in the second group of 450 patients between July 2015 and December 2017. There were no other technical changes between the two groups. Patient characteristics, the Charlson Comorbidity Index (CCI), and surgical data were collected from our database. PROM questionnaires, consisting of the Oxford Hip Score (OHS) and Core Outcome Measures Index (COMI-Hip), were collected two years postoperatively. Data were analyzed with generalized multiple regression analysis. Results The characteristics, CCI, operating time, and length of stay were similar in both groups. There was significantly less blood loss in the capsular preservation group (p = 0.037). The revision rate (n = 3, (0.6%) in the resected group, and 1 (0.2%) in the preserved group) did not differ significantly (p = 0.295). Once adjusted for demographic and surgical factors, the preserved group had significantly worse PROMs: + 0.24 COMI-Hip (p < 0.001) and -1.6 OHS points (p = 0.017). However, the effect sizes were much smaller than the minimal clinically important differences (MCIDs) of 0.95 and 5, respectively). The date of surgery (influencing, for instance, the surgeon’s age) was not a significant factor. Conclusion Based on the MCID, the lower PROMs in the capsular preservation group do not seem to have clinical relevance. They do not, however, confirm the expected benefit of capsular preservation reported for the posterolateral approach. Cite this article: Bone Joint J 2022;104-B(7):826–832.
The incidence of adverse local tissue reaction due to head taper corrosion after total hip arthroplasty using V40 taper and 36 mm CoCr head
Authors: Grothe Tim , Günther Klaus-Peter , Hartmann Albrecht , Blum Sophia , Haselhoff Richard , Goronzy Jens 
Published: July 2022

Aims Head-taper corrosion is a cause of failure in total hip arthroplasty (THA). Recent reports have described an increasing number of V40 taper failures with adverse local tissue reaction (ALTR). However, the real incidence of V40 taper damage and its cause remain unknown. The aim of this study was to evaluate the long-term incidence of ALTR in a consecutive series of THAs using a V40 taper and identify potentially related factors. Methods Between January 2006 and June 2007, a total of 121 patients underwent THA using either an uncemented (Accolade I, made of Ti12Mo6Zr2Fe; Stryker, USA) or a cemented (ABG II, made of cobalt-chrome-molybdenum (CoCrMo); Stryker) femoral component, both with a V40 taper (Stryker). Uncemented acetabular components (Trident; Stryker) with crosslinked polyethylene liners and CoCr femoral heads of 36 mm diameter were used in all patients. At a mean folllow-up of 10.8 years (SD 1.1), 94 patients (79%) were eligible for follow-up (six patients had already undergone a revision, 15 had died, and six were lost to follow-up). A total of 85 THAs in 80 patients (mean age 61 years (24 to 75); 47 (56%) were female) underwent clinical and radiological evaluation, including the measurement of whole blood levels of cobalt and chrome. Metal artifact reduction sequence MRI scans of the hip were performed in 71 patients. Results A total of 20 ALTRs were identified on MRI, with an incidence of 26%. Patients with ALTR had significantly higher median Co levels compared with those without ALTR (2.96 μg/l (interquartile range (IQR) 1.35 to 4.98) vs 1.44 μg/l (IQR 0.79 to 2.5); p = 0.019). Radiological evidence of osteolysis was also significantly associated with ALTR (p = 0.014). Median Cr levels were not significantly higher in those with ALTR compared with those without one (0.97 μg/l (IQR 0.72 to 1.9) v 0.67 μg/l (IQR 0.5 to 1.19; p = 0.080). BMI, sex, age, type of femoral component, head length, the inclination of the acetabular component, and heterotopic ossification formation showed no significant relationship with ALTR. Conclusion Due to the high incidence of local ALTR in our cohort after more than ten years postoperatively, we recommend regular follow-up investigation even in asymptomatic patients with V40 taper and metal heads. As cobalt levels correlate with ALTR occurrence, routine metal ion screening and consecutive MRI investigation upon elevation could be discussed. Cite this article: Bone Joint J 2022;104-B(7):852–858.
Modified acetabular component liner designs are not superior to standard liners at reducing the risk of revision
Authors: Krull Paula , Steinbrück Arnd , Grimberg Alexander W. , Melsheimer Oliver , Morlock Michael , Perka Carsten 
Published: July 2022

Aims Registry studies on modified acetabular polyethylene (PE) liner designs are limited. We investigated the influence of standard and modified PE acetabular liner designs on the revision rate for mechanical complications in primary cementless total hip arthroplasty (THA). Methods We analyzed 151,096 primary cementless THAs from the German Arthroplasty Registry (EPRD) between November 2012 and November 2020. Cumulative incidence of revision for mechanical complications for standard and four modified PE liners (lipped, offset, angulated/offset, and angulated) was determined using competing risk analysis at one and seven years. Confounders were investigated with a Cox proportional-hazards model. Results Median follow-up was 868 days (interquartile range 418 to 1,364). The offset liner design reduced the risk of revision (hazard ratio (HR) 0.68 (95% confidence interval (CI) 0.50 to 0.92)), while the angulated/offset liner increased the risk of revision for mechanical failure (HR 1.81 (95% CI 1.38 to 2.36)). The cumulative incidence of revision was lowest for the offset liner at one and seven years (1.0% (95% CI 0.7 to 1.3) and 1.8% (95% CI 1.0 to 3.0)). No difference was found between standard, lipped, and angulated liner designs. Higher age at index primary THA and an Elixhauser Comorbidity Index greater than 0 increased the revision risk in the first year after surgery. Implantation of a higher proportion of a single design of liner in a hospital reduced revision risk slightly but significantly (p = 0.001). Conclusion The use of standard acetabular component liners remains a good choice in primary uncemented THA, as most modified liner designs were not associated with a reduced risk of revision for mechanical failure. Offset liner designs were found to be beneficial and angulated/offset liner designs were associated with higher risks of revision. Cite this article: Bone Joint J 2022;104-B(7):801–810.
Policing a pandemic: changes in police response to intimate partner violence (IPV) during the first lockdown in England
Authors: Trafford Lucy 
Published: July 2022

This article investigates the police response to intimate partner violence (IPV) during the first lockdown in England (23 March–30 June 2020), a time when more people were confined to their homes and rates of IPV increased globally (Williamson et al, 2020). Having gained access to data for domestic abuse-flagged incidents from a south-eastern police force, this research compares quantitative data for 6808 incidents during the first lockdown in England with 6408 incidents during the equivalent 2019 timeframe. Quantitative analysis was conducted by comparing descriptive statistics and chi-squared testing.
This study finds that age distribution changed for victims and suspects, with IPV decreasing among younger age groups and increasing within older age categories. Shifts occurred in the categorisation of IPV crimes with an increase in crimes that can be committed remotely, most notably stalking and malicious communications. Additionally, the risk level differed for IPV incidents, with a reduction in incidents recorded as medium- and high-risk. Whereas, standard-risk incidents rose substantially, causing a change in the distribution of risk levels across reported incidents. This shift was reflected in fewer arrests, except among higher-risk incidents which maintained higher arrest rates. Official outcomes similarly decreased, with fewer court disposals and more simple cautions.
The prevalence and causes of pediatric uncorrected refractive error: Pooled data from population studies for Global Burden of Disease (GBD) sub-regions
Authors: Cao He , Cao Xiang , Cao Zhi , Zhang Lu , Han Yue , Guo Changchun 
Published: July 2022

BackgroundThere are limited systematic reviews on the prevalence of uncorrected refractive errors in children. We aimed to summarize the prevalence and causes of pediatric uncorrected refractive error (URE) from studies in the Global Burden of Disease (GBD) sub-regions.MethodsThe pooled analysis used the individual participant data (ages less than 20 years old) from population-based studies around the world by regions. URE was defined as presenting VA < 6/18 and improving to ≥ 6/18 or ≥1 line on using a pinhole in either eye, with main causes of myopia, hyperopia or astigmatism. Each study provided data on any URE, myopia, hyperopia or astigmatism by age, gender, and ethnicity. Prevalence rates were directly age and gender standardized to the 2020 world population with all age groups. Estimates were calculated by study and sub-regions after pooling. Summary estimates included studies in which URE was assessed from a pinhole-corrected refraction in the better eye.ResultsThe combined pooled data contained 302,513,219 patients including 8 963 URE cases individuals from 57 studies. Prevalence varied by age and GBD sub-regions and differed by gender. The age- and region-standardized prevalence of URE was 3.41 per 1000 (CI, 1.53~7.62) in Western Pacific region (12 studies), 2.26 per 1000 (CI, 0.85~6.01) in South-East Asia region (14 studies), 5.85 per 1000 (CI, 3.75~9.13) in Americans (11 studies) and 4.40 per 1000 (CI, 3.0~6.45) in Eastern Mediterranean region (13 studies). On the basis of these data, myopia was the first-leading cause in female children with 12~17 age group, with the prevalence rate 18.2 per 1000 (CI, 11.52~23.61). Astigmatism was detected in 27.2 per 1000 male children with 6~11 age group (CI: 19.12–30.68).ConclusionsPrevalence of URE available data within these sub-regions are widely disparate. Myopia and astigmatism in young age children continue as the leading cause of URE worldwide. Providing appropriate refractive correction to those individuals whose vision can be improved is an important public health endeavor with implications for safety and quality of life.
Research on performance and dynamic competency evaluation of bid evaluation experts based on weight interval number
Authors: Li Tie , Li Guoliang , Zhang Mi , Qin Yuan , Wei Guolong 
Published: July 2022

Purpose/Significance
In the past many years, some scholars have studied bid evaluation experts, such as the behavior of bid evaluation experts. However, previous research ignores the performance and competency of bid evaluation experts, so this paper aims to provide a theoretical basis for incentive and constraint mechanism and hierarchical or dynamic management of bid evaluation experts by implementing performance and dynamic competency evaluation of bid evaluation experts.

Method/Process
Firstly, the evaluation index system of performance and dynamic competency of bid evaluation experts is preliminarily constructed by referring to relevant literature, and then the constructed evaluation index was modified and improved by consulting relevant stakeholders’ experts. Secondly, considering the hesitation and consistency of expert weighting, the calculation method of expert weight coefficient and index score interval number is improved. Based on the theory of weight interval number, the corresponding mathematical optimization model is constructed to calculate the index weight according to the purpose of performance judgment and dynamic competency clustering of bid evaluation experts. Finally, the data of performance and dynamic competency of bid evaluation experts is obtained by questionnaire survey, and the empirical analysis was carried out by simulating the bid evaluation experts consistent with the actual situation.

Results/Conclusion
After improving the calculation method of index score interval number, and then calculating index weight interval number through index score interval number, the length of index weight interval number can be decreased and the calculation accuracy of index weight interval number can be increased. In addition, the index weight calculated by the constructed mathematical optimization model can make the intra-class discrimination smaller and the inter-class discrimination larger. Finally, some suggestions are also provided for the management of bid evaluation experts.
Implications of COVID-19 labour market shock for child and household hungers in South Africa: Do social protection programs protect?’
Authors: Gelo Dambala , Dikgang Johane 
Published: July 2022

Background
Recent studies have confirmed that the COVID-19 lockdown has caused massive job losses. However, the impact of this loss on food security is not well-understood. Moreover, a paucity of evidence exists regarding social protection grants’ countervailing effects against such shocks. This study examined the effects of job loss (labour income loss) on child and household hungers (our two measures food insecurity) during COVID-19 pandemic in South Africa. It also ascertained whether these effect were offset by alternative social grant programs to document the protective role of the latter.

Data and methods
We used South Africa’s National Income Dynamics Study (NIDS) and the Coronavirus Rapid Mobile Survey (CRAM) data. These data cover a nationally representative sample of 7073 individuals. We employed a probit model to estimate the effect of job loss and receipts of various social grants on child and households’ hungers. We also estimated the double-selection logit model to account for the model’s uncertainty surrounding the variable selection and treatment-effects estimation using lasso (Telasso) for causal inference of our analysis.

Results
Our analyses showed that households exposed to a labour market shock during the pandemic experienced a significant increase in our measures of food insecurity (child and household hungers). Specifically, we found that compared with households containing employed respondents, households with respondents who lost their jobs due to COVID-19 lockdown were 5.4% more likely to report child hunger and 2.6% more likely to report household hunger in the past seven days A receipt of child support grant reduces the likelihood of reporting child hunger and household hunger by 21.7%and 16.9% respectively among these households. A receipt of old age pension grant reduces the likelihood of reporting household hunger by 24% with no significant effect on child hunger.

Conclusion
The COVID-19 lockdown resulted in unprecedent job losses with significant implications for food insecurity. Job loss due to COVID-19 lockdown significantly increased food insecurity in South Africa. Receipts of social grants effectively offset this adverse effect. The protective effect of the social grant is heterogenous across its alternative programs (child support grant and old age pension grant) and food insecurity, suggesting the differences in the size of transfers and motivations for sending these transfers.
Diagnostic of FibroTouch and six serological models in assessing the degree of liver fibrosis among patients with chronic hepatic disease: A single-center retrospective study
Authors: Zuo Zhongbao , Cui Huaizhong , Wang Miaochan , Huang Congxiang , Wu Jing , Tao Chengjing , Li Zhaoyi , Yang Chunli , Pan Kenv , Bao Jianfeng , Liu Shourong , Xu Aifang 
Published: July 2022

Background and aims
The aim of this study was to evaluate the diagnostic value of FibroTouch and serological models on staging hepatic fibrosis in chronic liver diseases.

Methods
We recruited 850 patients undergoing liver biopsy and received FibroTouch test before or after liver biopsy within one week, blood was taken for the routine inspection before the operation within one week. The serological models were calculated by the blood results and routine clinical information. The diagnostic value of FibroTouch and six serological models was analyzed by receiver operating characteristic curve (ROC).

Results
Patients with severe liver fibrosis had significantly higher AST, ALT, GGT, RDW, ALP, and FT-LSM. The area under the receiver operating characteristic curve (AUROC) of FT-LSM for the liver diagnosis of S≥2, S≥3 and S = 4 was 0.75(95% confidence interval [CI]:0.72–0.78), 0.83(95% CI: 0.80–0.86), and 0.85 (95% CI: 0.81–0.89), respectively. The optimal cut-off of FT-LSM for diagnosing S≥2, S≥3 and S = 4 was 8.7, 10.7, and 12.3, respectively.

Conclusions
Our study showed the FibroTouch has a higher diagnostic value compared with the non-invasive serological models in staging the fibrosis stage. The cut-off of FibroTouch and five serological models (APRI, FIB-4, S-index, Forns, and PRP) increased with the severe of fibrosis stage.
A pilot phase Ib/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: First experience from Africa
Authors: Saleh Mansoor , Sharma Karishma , Shah Jasmit , Karsan Farrok , Waweru Angela , Musumbi Martin , Shah Reena , Sayed Shahin , Abayo Innocent , Karimi Noureen , Gondi Stacey , Rupani Sehrish , Kirathe Grace , Amariati Heldah 
Published: July 2022

Background
Low dose radiation therapy (LDRT) has been used for non-malignant conditions since early 1900s based on the ability of single fractions between 50–150 cGy to inhibit cellular proliferation. Given scarcity of resources, poor access to vaccines and medical therapies within low and middle income countries, there is an urgent need to identify other cost-effective alternatives in management of COVID-19 pneumonia. We conducted a pilot phase Ib/II investigator-initiated clinical trial to assess the safety, feasibility, and toxicity of LDRT in patients with severe COVID-19 pneumonia at the Aga Khan University Hospital in Nairobi, Kenya. Additionally, we also assessed clinical benefit in terms of improvement in oxygenation at day 3 following LDRT and the ability to avoid mechanical ventilation at day 7 post LDRT.

Methods
Patients with both polymerase chain reaction (PCR) and high-resolution computer tomogram (HRCT) confirmed severe COVID-19 pneumonia, not improving on conventional therapy including Dexamethasone and with increasing oxygen requirement were enrolled in the study. Patients on mechanical ventilation were excluded. Eligible patients received a single 100cGy fraction to the whole lung. In the absence of any dose limiting toxicity the study proposed to treat a total of 10 patients. The primary endpoints were to assess the safety/feasibility, and toxicity within the first 24 hours post LDRT. The secondary endpoints were to assess efficacy of LDRT at Day 3, 7, 14 and 28 post LDRT.

Results
Ten patients were treated with LDRT. All (100%) of patients were able to complete LDRT without treatment related SAE within the first 24 hours post treatment. None of the patients treated with LDRT experienced any acute toxicity as defined by change in clinical and respiratory status at 24hr following LDRT. Majority (90%) of patients avoided mechanical ventilation within 7 days of LDRT. Four patients (40%) demonstrated at least 25% improvement in oxygen requirements within 3 days. Six patients (60%) were discharged and remained off oxygen, whereas four progressed and died (1 due to sepsis and 3 in cytokine storm). Median time to discharge (n = 6) was 16.5 days and median time to death (n = 4) was 11.0 days. Patients who ultimately died showed elevated inflammatory markers including Ferritin, CRP and D-dimers as compared to those who were discharged alive.

Conclusion
LDRT was feasible, safe and shows promise in the management of severe COVID-19 pneumonia including in patients progressing on conventional systemic treatment. Additional phase II trials are warranted to identify patients most likely to benefit from LDRT.
Design and performance optimization of 96 x 40 Gbps CSRZ based DWDM long-haul system
Authors: Ghera Jaswinder Singh , Sharma Vikrant 
Published: July 2022

Abstract
In this paper, we have designed and presented a simulation analysis of 96 × 40 Gbps CSRZ based DWDM long-haul transmission system under the influence of Kerr non-linearities using hybrid dispersion compensation technique. The proposed system performance is measured at 50 GHz channel spacing in terms of BER, Q-factor and eye-diagram for the varied launched power ranging from −4 dB m to 12 dB m of CW laser array and various transmission distances. We have implemented pre-filtering before multiplexing the modulated data of all the channels and post-filtering after de-multiplexing for avoiding co-channel interference and to suppress the cross-talk. By optimizing the system parameters, the transmission distance of 16,500 km is achieved for BER value of 1.48,875E-14 with corresponding Q-factor value of 7.55,989 at 6 dB m input power. The CSRZ modulated system has shown much robustness against the occurred linear and non-linear degradation factors due to its narrow spectrum.
The molecular mechanisms that underlie neural network assembly
Authors: Ye Bing 
Published: July 2022

Abstract
Neural networks are groups of interconnected neurons, which collectively give rise to emergent neural activities and functions that cannot be explained by the activity of single neurons. How neural networks are assembled is poorly understood. While all aspects of neuronal development are essential for the assembly of a functional neural network, we know little about high-level principles that govern neural network assembly beyond the basic steps of neuronal development. In this review, I use vertebrate spinal motor columns, Drosophila larval motor circuit, and the lamination in the vertebrate inner retina to highlight the spatial codes, temporal codes, and cell adhesion codes for neural network assembly. Nevertheless, these examples only show preliminary connections between neural network development and their functions. Much needs to be done to understand the molecular mechanisms that underlie the assembly of functional neural networks.