bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chaotic simplex moth swarm algorithm for optimization of alternative energy integrated power grid including static synchronous series compensator
Authors: Banerjee Dhiman , Roy Provas Kumar , Panda Gautam Kumar 
Published: July 2022

AbstractAn optimal power flow (OPF) model is developed in this paper, which includes three highly volatile energy sources: wind energy, photovoltaic energy, and electric vehicle as a vehicle to grid energy source. An interpretable probabilistic approach is implemented to estimate the power generation from the mentioned energy sources using different probability distribution functions. A single static synchronous series compensator is optimally configured and positioned in the combined grid power system to achieve balanced operation. This significant uncertainty imposed OPF model is solved by blending (a) chaotic mapping technique, and (b) Nelder–mead simplex method with conventional moth swarm algorithm (MSA) and the modified version of MSA is called chaotic simplex MSA (CSMSA). Proposed CSMSA's performance is evaluated analytically using extensive simulation approaches that include six different power‐related simulation instances considering IEEE 30 and 118‐bus test grid systems. The strength of the proposed CSMSA is examined by comparing its performance to five outstanding metaheuristic techniques.
Impact of searching clinical trials registers in systematic reviews of pharmaceutical and non‐pharmaceutical interventions: Reanalysis of meta‐analyses
Authors: Alqaidoom Zainab , Nguyen Phi‐Yen , Awadh Maryam , Page Matthew J. 
Published: July 2022

AbstractSystematic reviewers are advised to search trials registers to minimise risk of reporting biases. However, there has been little research on the impact of searching trials registers on the results of meta‐analyses. We aimed to evaluate the impact of searching clinical trials registers for systematic reviews of pharmaceutical or non‐pharmaceutical interventions. We searched PubMed, Scopus, Science Citation Index and Social Sciences Citation Index, and Education Collection for systematic reviews with meta‐analyses indexed from 2 November to 2 December 2020. A random sample of systematic reviews was initially drawn, and for reviews which considered randomised trials eligible for inclusion, which had not searched a trials register, we searched ClinicalTrials.gov, EudraCT, ANZCTR, and the WHO ICTRP search portal for eligible trials. We compared meta‐analytic effect estimates before and after including results from additional trials identified. We found additional trials for 63% (63/101) of eligible reviews; however, trials with results that could contribute to a meta‐analysis were identified for only 20% (20/101) of the reviews. On average, there was no difference in the meta‐analytic effect estimates before versus after adding the new trials. In summary, searching clinical trial registers led to identification of additional trials for many reviews; however, very few trials had results available for inclusion in meta‐analyses. Including results from the new trials led to no change in the meta‐analytic estimates, on average. Trials registers would be even more valuable to systematic reviewers if more trialists made use of them (i.e., registered their trials and posted results in a timely manner).
Comparing methods for handling missing covariates in meta‐regression
Authors: Lee Jihyun , Beretvas S. Natasha 
Published: July 2022

AbstractMeta‐analysts often encounter missing covariate values when estimating meta‐regression models. In practice, ad hoc approaches involving data deletion have been widely used. The current study investigates the performance of different methods for handling missing covariates in meta‐regression, including complete‐case analysis (CCA), shifting‐case analysis (SCA), multiple imputation (MI), and full information maximum likelihood (FIML), assuming missing at random mechanism. According to the simulation results, we advocate the use of MI and FIML than CCA and SCA approaches in practice. In addition, we cautiously note the challenges and potential advantages of using MI in the meta‐analysis context.
5,291‐ppi OLED display enabled by monolithic integration of C‐axis‐aligned crystalline IGZO FET and Si CMOS
Authors: Kato Kiyoshi , Kobayashi Hidetomo , Shishido Hideaki , Isa Toshiyuki , Aoyama Tomoya , Jimbo Yasuhiro , Hodo Ryota , Kusunoki Koji , Kunitake Hitoshi , Yamazaki Shunpei 
Published: July 2022

AbstractFor the first time in the world, we have fabricated an organic light‐emitting diode (OLED) display that monolithically integrates Si CMOS and oxide semiconductor FETs (OSFETs). OSFETs can be monolithically stacked on Si CMOS. With this OS/Si monolithic stack technology, we have fabricated driver circuits with Si CMOS and pixel circuits with OSFETs. This enables displays to have thin bezels. In addition, fabricating pixel circuits with OSFETs, which have higher breakdown voltage than Si CMOS, allows the use of tandem OLED devices that require high driving voltage. This enables an OLED display with a pixel density over 5,000 ppi.
Impact of resection margin status on survival after operation for pancreatic head cancer with extrapancreatic nerve plexus invasion
Authors: Konishi Takanori , Takano Shigetsugu , Furukawa Katsunori , Takayashiki Tsukasa , Kuboki Satoshi , Suzuki Daisuke , Sakai Nozomu , Hosokawa Isamu , Mishima Takashi , Ohtsuka Masayuki 
Published: July 2022

AbstractBackgroundExtrapancreatic nerve plexus (PL) invasion of pancreatic ductal adenocarcinoma (PDAC) is an important factor for determining resectability and surgical method. We sought to clarify the characteristics of PDAC with PL invasion and clinical impact of the resection margin status on prognosis for PDAC with PL invasion.MethodsA total of 242 patients with pancreatic head cancer who underwent pancreatectomy were evaluated. Clinicopathological data and patient survival were analyzed.ResultsPathological PL invasion was observed in 68 patients (28.1%). Patients with PL invasion had significantly shorter disease‐free survival (DFS) and showed trends toward worse overall survival (OS) than those without PL invasion. While multivariate analysis revealed that PL invasion was not an independent prognostic factor, PL invasion was associated with extensive venous invasion and a high percentage of lymph node metastases, both of which were independent factors affecting DFS and OS. Among patients with PL invasion, there was no significant difference in DFS and OS between the R0 and R1 resection groups.ConclusionsPL invasion is a common pathological feature of aggressive PDAC with high propensity for invasiveness and metastatic potential. The microscopic resection margin status may not affect the survival of pancreatic head cancer patients with PL invasion.
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration
Authors: Cui Shangbin , Li Wenyue , Teixeira Graciosa Q. , Neidlinger‐Wilke Cornelia , Wilke Hans‐Joachim , Haglund Lisbet , Ouyang Hongwei , Richards R. Geoff , Grad Sibylle , Alini Mauro , Li Zhen 
Published: July 2022

AbstractBackgroundDuring the intervertebral disc (IVD) degeneration process, initial degenerative events occur at the extracellular matrix level, with the appearance of neoepitope peptides formed by the cleavage of aggrecan and collagen. This study aims to elucidate the spatial and temporal alterations of aggrecan and collagen neoepitope level during IVD degeneration.MethodsBovine caudal IVDs were cultured under four different conditions to mimic different degenerative situations. Samples cultured after 1‐ or 8‐days were collected for analysis. Human IVD samples were obtained from patients diagnosed with lumbar disc herniation (LDH) or adolescent idiopathic scoliosis (AIS). After immunohistochemical (IHC) staining of Aggrecanase Cleaved C‐terminus Aggrecan Neoepitope (NB100), MMP Cleaved C‐terminus Aggrecan Neoepitope (MMPCC), Collagen Type 1α1 1/4 fragment (C1α1) and Collagenase Cleaved Type I and II Collagen Neoepitope (C1,2C), staining optical density (OD)/area in extracellular matrix (OECM) and pericellular zone (OPCZ) were analyzed. Conditioned media of the bovine IVD was collected to measure protein level of inflammatory cytokines and C1,2C.ResultsFor the bovine IVD sections, the aggrecan MMPCC neoepitope was accumulated in nucleus pulposus (NP) and cartilage endplate (EP) regions following mechanical overload in the one strike model after long‐term culture; as for the TNF‐α induced degeneration, the OECM and OPCZ of collagen C1,2C neoepitope was significantly increased in the outer AF region after long‐term culture; moreover, the C1,2C was only detected in conditioned medium from TNF‐α injection + Degenerative loading group after 8 days of culture. LDH patients showed higher MMPCC OECM in NP and higher C1,2C OECM in AF region compared with AIS patients.ConclusionsIn summary, aggrecan and collagen neoepitope profiles showed degeneration induction trigger‐ and region‐specific differences in the IVD organ culture models. Different IVD degeneration types are correlated with specific neoepitope expression profiles. These neoepitopes may be helpful as biomarkers of ECM degradation in early IVD degeneration and indicators of different degeneration phenotypes.
Gold Nanoparticle Embedded Stimuli‐Responsive Functional Glycopolymer: A Potential Material for Synergistic Chemo‐Photodynamic Therapy of Cancer Cells
Authors: Bhattacharya Koushik , Das Subhayan , Kundu Moumita , Singh Sudarshan , Kalita Uddhab , Mandal Mahitosh , Singha Nikhil K. 
Published: July 2022

AbstractPhotodynamic therapy has emerged as a noninvasive treatment modality for several types of cancers. However, conventional hydrophobic photosensitizers (PS) suffer from low water solubility and poor tumor‐targeting ability. Therefore, PS modified with glycopolymers can offer adequate water solubility, biocompatibility, and tumor‐targeting ability due to the presence of multiple sugar units. In this study, a well‐defined block copolymer poly(3‐O‐methacryloyl‐d‐glucopyranose)‐b‐poly(2‐(4‐formylbenzoyloxy)ethylmethacrylate) (PMAG‐b‐PFBEMA) containing pendant glucose and aldehyde units is synthesized via reversible addition‐fragmentation chain transfer polymerization method. A water‐soluble PS (toluidine blue O; TBO) and a potent anticancer drug, Doxorubicin (Dox) are introduced to the polymer backbone via acid‐labile Schiff‐base reaction (PMAG‐b‐PFBEMA_TBO_Dox). The PMAG‐b‐PFBEMA_TBO_Dox is then anchored on the surface of gold nanoparticles (AuNPs) via electrostatic interaction. This hybrid system exhibits excellent reactive oxygen species (ROS) generating ability under exposure of 630 nm light‐emitting diode along with triggered release of Dox under the acidic pH of tumor cells. The in vitro cytotoxicity study on human breast cancer cell line, MDA MB 231, for this hybrid system shows promising results due to the synergistic effect of ROS and Dox released. Thus, this glycopolymer‐based dual (chemo‐photodynamic) therapy model can work as potential material for future therapeutics.
Corrosion challenges towards a sustainable society
Authors: Bender Roman , Féron Damien , Mills Douglas , Ritter Stefan , Bäßler Ralph , Bettge Dirk , De Graeve Iris , Dugstad Arne , Grassini Sabrina , Hack Theo , Halama Maros , Han En‐Hou , Harder Thomas , Hinds Gareth , Kittel Jean , Krieg Romina , Leygraf Christofer , Martinelli Laure , Mol Arjan , Neff Delphine , Nilsson Jan‐Olov , Odnevall Inger , Paterson Steve , Paul Shiladitya , Prošek Tomáš , Raupach Michael , Revilla Reynier I. , Ropital François , Schweigart Helmut , Szala Elizabeth , Terryn Herman , Tidblad Johan , Virtanen Sannakaisa , Volovitch Polina , Watkinson David , Wilms Marc , Winning George , Zheludkevich Mikhail 
Published: July 2022

AbstractA global transition towards more sustainable, affordable and reliable energy systems is being stimulated by the Paris Agreement and the United Nation's 2030 Agenda for Sustainable Development. This poses a challenge for the corrosion industry, as building climate‐resilient energy systems and infrastructures brings with it a long‐term direction, so as a result the long‐term behaviour of structural materials (mainly metals and alloys) becomes a major prospect. With this in mind “Corrosion Challenges Towards a Sustainable Society” presents a series of cases showing the importance of corrosion protection of metals and alloys in the development of energy production to further understand the science of corrosion, and bring the need for research and the consequences of corrosion into public and political focus. This includes emphasis on the limitation of greenhouse gas emissions, on the lifetime of infrastructures, implants, cultural heritage artefacts, and a variety of other topics.
Strong Hydrophobic and Ultraviolet Reflective Film from Fluorinated Polyisoprene with Microphase Separation via Thiol–Epoxy Click Chemistry
Authors: Liu Huan , Cheng Shihong , Yang Yadong , Wang Chunlin , Zhu Shijiang , Zhao Fuchun 
Published: July 2022

AbstractPolyisoprene is widely used in the industrial production of tires, thermoplastic elastomers, pressure sensitive adhesives, coatings, plasticizers, lubricants, and other functional materials. However, due to the inherent molecular defect of containing many unsaturated double bonds, polyisoprene exhibits relatively weak environmental endurance, especially under extreme environmental conditions. To incorporate the excellent features of fluorinated polymer such as tough environmental endurance, a new type of fluorinated polyisoprene is tailored and a facile procedure of introducing fluoroalkyl side chains onto polyisoprene backbone is carried out via epoxidation and thiol–epoxy click chemistry under mild conditions. The results demonstrate that fluorinated alkyl side chains are successfully clicked onto backbone chains of polyisoprene and the corresponding film exhibits a microphase separation structure. As for the fluorinated polyisoprene film after the introduction of fluoroalkyl groups, the water contact angle enhances significantly from 79.4° to 114.8° and the UV reflectivity improves markedly. In addition, the surface chemical constituents confirm that the incorporated fluoroalkyl groups have a tendency to migrate and enrich spontaneously onto the film surface.
Compact planar ultra‐wideband pattern diversity antenna
Authors: Ellis Mubarak S. , Nourinia Javad , Ghobadi Changiz , Mohammadi Bahman 
Published: July 2022

AbstractA two‐port planar ultra‐wideband (UWB) pattern diversity antenna is proposed in this letter. The design consists of an array of two rotated identical monopole antennas and two feeding ports with 0° in‐phase and 180° out‐of‐phase excitations. The single monopole antenna includes a circular patch, a rectangular truncated ground plane and a fork‐shaped feeding structure. In this antenna, a modified partial common ground plane is used to enhance the input matching, increase the isolation between antenna elements and improve the desired radiations. The measured results show an |S11| < −10 dB bandwidth ranging from 2 to over 20GHz, with conical and broadside beams, high efficiency, and good isolation across the entire UWB band. Also, the proposed antenna exhibits a smaller footprint, larger bandwidth, and more straightforward design compared with the existing designs. To the best of authors’ knowledge, all these characteristics have never been presented in previously reported UWB pattern diversity antennas.
A compendious review on fatigue properties of the bio‐nanocomposites
Authors: Aravind Dhandapani , Senthilkumar Krishnasamy , Chandrasekar Muthukumar , Senthil Muthu Kumar Thiagamani , Ganesan C. , Parameswaranpillai Jyotishkumar , Rajini Nagarajan , Siengchin Suchart , Varagunapandiyan Natarajan 
Published: July 2022

AbstractIn this present work, a review of fatigue strength on bio‐nano composites was presented. Generally, the biocomposites possessed higher fatigue strength than the conventional materials. Because the propagation in biocomposites can be arrested due to their internal structure, whereas the damages occur in the matrix and/or at the fiber/matrix interface region. In the case of conventional materials, the cracks would rapidly grow until a catastrophic failure occurs. Thus, the S–N curves of composites show a flatter curve when compared to the conventional materials. In terms of fatigue properties, conventional fiber‐reinforced composites (e.g., glass and carbon‐reinforced composites) were more extensively studied than bio‐based reinforced composites. Examining the fatigue properties of materials is significant for all engineering‐based applications. Because the fatigue failures can occur below the ultimate tensile strength of materials. However, the fatigue performance of the composites can be enhanced by improving the fiber‐matrix interfacial bonding resulting from surface treatment of fibers and incorporating nanofillers within the matrix, and so forth. Since the nanocomposites have a larger surface area and aspect ratio, they are preferred to use in many applications: aerospace, automotive, biotechnology, construction, and building, electronics, marine, and packing industries. Thus, this chapter starts with the unique advantages of bio‐nano composites. Then, the fatigue properties of bio‐nano composites, the significance of the S–N diagram, and the pattern of fatigue testing were discussed. In order to understand the fatigue behavior, several factors such as structure, fillers, fabrication techniques, and so forth were included. Challenges of fatigue strength of biocomposites were also summarized.
Advancing quantification methods for polyphenols in brown seaweeds—applying a selective qNMR method compared with the TPC assay
Authors: Wekre Marie Emilie , Hellesen Brunvoll Sondre , Jordheim Monica 
Published: July 2022

AbstractIntroductionBrown seaweeds are a sustainable biomass with a potential for various industrial applications. Polyphenols are an important contributor to this potential.ObjectiveThe aim was total quantification of polyphenols in brown seaweeds from different tidal zones, using a selective 1H quantitative NMR (qNMR) method, comparing the results with the colorimetric Folin–Ciocalteu total phenolic content (TPC) assay.MethodqNMR was performed with integration of selected peaks in the aromatic region (7–5.5 ppm). Deselection of non‐polyphenolic 1H signals was based on information from 2D (1H‐13C, 1H‐15N) NMR spectra. 13C NMR phlorotannin characterisation facilitated the average number of protons expected to be found per aromatic ring used for the 1H quantification.ResultsSelective qNMR and the TPC assay showed similar results for the three sublittoral growing species from the Laminariaceae; lower amounts for Laminaria hyperborea and Laminaria digitata (qNMR: 0.4%–0.6%; TPC: 0.6%–0.8%, phloroglucinol equivalents (PGE), dry weight (DW)) and higher amounts for Saccharina latissima (qNMR: 1.2%; TPC: 1.5%, PGE, DW). For the eulittoral Fucaceae, Fucus vesiculosus (qNMR: 1.1%; TPC: 4.1%; PGE, DW) and Ascophyllum nodosum (qNMR: 0.9%; TPC: 2.0%; PGE, DW), the TPC results were found to be up to three times higher than the qNMR results. The 13C NMR characterisation showed the highest phlorotannin polymerisation degree for F. vesiculosus.ConclusionThe TPC assay provided similar polyphenolic amounts to the selective qNMR method for sublittoral species. For eulittoral growing species, the TPC method showed amounts up to three times higher than the qNMR method—most likely illustrating the lack of selectivity in the TPC assay.
Enhanced properties of poly(silylene phenylether arylacetylene) by a side cyano group
Authors: Li Chuan , Ma Manping , Tang Junkun , Yuan Qiaolong , Huang Farong 
Published: July 2022

AbstractPoly(silylene arylacetylene) resin is a type of thermosetting resin with high heat resistance and good mechanical performance. A cyano group was introduced into a 1,3‐bis(4‐ethynylphenoxy)benzene, and thus a poly(silylene phenylether arylacetylene) with a side cyano group (PCNSA‐MP) was obtained by the polymerization of 2,6‐bis‐(4‐ethynylphenoxy)benzonitrile and dichlormethylphenylsilane under a catalyst. The structures and properties of PCNSA‐MP and poly(silylene phenylether arylacetylene) (PSEA‐MP) resins and the mechanical properties of T300/resin composites were studied. The results show that both PCNSA‐MP and PSEA‐MP resins possess good heat resistance. Especially, the PCNSA‐MP resin with the cyano group exhibits lower curing temperature, better heat resistance, and higher mechanical properties as compared with PSEA‐MP resin. The Td5 of the cured PCNSA‐MP resin arrives at 491°C and there is no significant glass transition below 450°C for the resin. The flexural strengths of the cured PCNSA‐MP resin and T300/ PCNSA‐MP composite reach 55.2 MPa and 433.8 MPa, respectively.
Forced expiratory flows and diffusion capacity in infants born from mothers with pre‐eclampsia
Authors: Ren Clement L. , Slaven James E. , Haas David M. , Haneline Laura S. , Tiller Christina , Hogg Graham , Bjerregaard Jeffrey , Tepper Robert S. 
Published: July 2022

AbstractRationaleAnimal models suggest pre‐eclampsia (Pre‐E) affects alveolar development, but data from humans are lacking.ObjectiveAssess the impact of Pre‐E on airway function, diffusion capacity, and respiratory morbidity in preterm and term infants born from mothers with Pre‐E.MethodsInfants born from mothers with and without Pre‐E were recruited for this study; term and preterm infants were included in both cohorts. Respiratory morbidity in the first 12 months of life was assessed through monthly phone surveys. Raised volume rapid thoracoabdominal compression and measurement of diffusion capacity of the lung to carbon monoxide (DLCO) were performed at 6 months corrected age.Measurements and Main ResultsThere were 146 infants in the Pre‐E cohort and 143 in the control cohort. The Pre‐E cohort was further divided into nonsevere (N = 41) and severe (N = 105) groups. There was no significant difference in DLCO and DLCO/alveolar volume among the three groups. Forced vital capacity was similar among the three groups, but the nonsevere Pre‐E group had significantly higher forced expiratory flows than the other two groups. After adjusting for multiple covariates including prematurity, the severe Pre‐E group had a lower risk for wheezing in the first year of life compared to the other two groups.ConclusionsPre‐E is not associated with reduced DLCO, lower forced expiratory flows, or increased wheezing in the first year of life. These results differ from animal models and highlight the complex relationships between Pre‐E and lung function and respiratory morbidity in human infants.