bluuebunny/crossref_metadata_2025_split huggingface dataset:
From managing risk to increasing resilience: a review on the development of urban flood resilience, its assessment and the implications for decision making
Authors: Rözer Viktor , Mehryar Sara , Surminski Swenja 
Published: December 2022

Abstract
Driven by urban growth in hazard prone areas such as along coasts or rivers as well as by climate change induced sea-level rise and increase in extreme rainfall, flood risk in urban areas is increasing. Better understanding of risks, risk drivers and its consequences in urban areas have revealed shortcomings in the existing flood risk management approaches. This has led to a paradigm shift in dealing with floods from managing the risk to reduce damages, to making urban communities resilient to flooding. Often described as a complex and at times confusing concept, this systematic review identifies and summarises the different dimensions and approaches of urban flood resilience and how they are applied in practice. Our analysis shows that urban flood resilience as a concept has evolved over the last two decades. From an engineering concept with a strong focus on ensuring that the built environment can withstand a flood to a more recent definition as a transformative process with the aim to enable all parts of the urban system to live with floods and learn from previous shocks. This evolved understanding is also reflected in the increasing number of dimensions considered in urban flood resilience assessments and decision support tools. A thematic analysis of the challenges in conceptualising and applying urban flood resilience reported in the literature has revealed a number of issues including around fairness and equity of the applied approaches, a lack of data and widely accepted methods as well as uncertainty around changing risks as a result of climate change. Based on these findings we propose a new research agenda, focusing on meta studies to identify the key dimensions and criteria for urban flood resilience, supporting a transparent and evidence-led operationalization.
Spring heat waves drive record western United States snow melt in 2021
Authors: McEvoy Daniel J , Hatchett Benjamin J 
Published: December 2022

Abstract
Throughout the western US snow melted at an alarming rate in April 2021 and by May 1, hydrologic conditions were severely degraded with declining summer water supply forecasts compared to earlier in the winter. The objectives of this study are to (a) quantify the magnitude and climatological context of observed melt rates of snow water equivalent (SWE) and (b) underpin the hydrometeorological drivers during April 2021 based on atmospheric reanalysis and gridded meteorological data. Peak SWE indicated snow drought conditions were widespread (41% of stations between 5th and 20th percentile) but not necessarily extreme (only 9% of stations less than 5th percentile). Here, using observations from the Snow Telemetry (SNOTEL) network we found record 7 day snow melt rates (median of −99 mm; ±one standard deviation of 61 mm) occurred at 24% of SNOTEL sites and in all 11 Western states. Strong upper atmospheric ridging that began initially in the north Pacific with eastward propagation by mid-April to the Pacific Northwest Coast led to near-surface conditions across the western US conducive to rapid snow loss. One heat wave occurred inland across the Rockies the first week of April and then later in April, a second heat wave impacted the Cascades and northern California. We find that ripening of the snowpack by both record high surface solar radiation and air temperatures were factors in driving the rapid snow melt. Equatorial Pacific sea surface temperatures and the La Niña pattern that peaked in winter along with an eastward propagating and intensifying Madden–Julian Oscillation were likely responsible for driving the placement, strength, and progression of the north Pacific Ridge. This study documents the role of two extreme spring ‘sunny heat wave’ events on snowpack, and the cascading drought impacts which are anticipated to become more frequent in a warming world.
All-organic modification coating prepared with large-scale atmospheric-pressure plasma for mitigating surface charge accumulation
Authors: ZHANG Penghao , YU Liang , HE Dazhao , TANG Xinyu , CHEN Shuo , DONG Shoulong , YAO Chenguo 
Published: December 2022

Abstract
The surface charge accumulation on polymers often leads to surface flashover. Current solutions are mainly based on the introduction of inorganic fillers. The high-cost process and low compatibility remain formidable challenges. Moreover, existing researches on all-organic insulation focus on capturing electrons, contrary to alleviating charge accumulation. Here, an all-organic modification coating was prepared on polystyrene (PS) with the large-scale atmospheric-pressure plasma, which exhibits outperformed function in mitigating surface charge accumulation. The surface charge dissipation rate and surface conductivity are promoted by about 1.37 and 9.45 times, respectively. Simulation and experimental results show that this all-organic modification coating has a smaller electron affinity potential compared with PS. The decrease of electron affinity potential may result in accelerated surface charge decay of PS, which has never been involved in previous works. Moreover, this coating also has good reliability in a repeated surface flashover. This facile and large-scale approach brings up a novel idea for surface charge regulation and the manufacture of advanced dielectric polymers.
Genetic and demographic signatures accompanying the evolution of the selfing syndrome inDaphne kiusiana, an evergreen shrub
Authors: Han Eun-Kyeong , Tamaki Ichiro , Oh Sang-Hun , Park Jong-Soo , Cho Won-Bum , Jin Dong-Pil , Kim Bo-Yun , Yang Sungyu , Son Dong Chan , Choi Hyeok-Jae , Gantsetseg Amarsanaa , Isagi Yuji , Lee Jung-Hyun 
Published: December 2022

AbstractBackground and AimsThe evolution of mating systems from outcrossing to self-fertilization is a common transition in flowering plants. This shift is often associated with the ‘selfing syndrome’, which is characterized by less visible flowers with functional changes to control outcrossing. In most cases, the evolutionary history and demographic dynamics underlying the evolution of the selfing syndrome remain poorly understood.MethodsHere, we characterize differences in the demographic genetic consequences and associated floral-specific traits between two distinct geographical groups of a wild shrub, Daphne kiusiana, endemic to East Asia; plants in the eastern region (southeastern Korea and Kyushu, Japan) exhibit smaller and fewer flowers compared to those of plants in the western region (southwestern Korea). Genetic analyses were conducted using nuclear microsatellites and chloroplast DNA (multiplexed phylogenetic marker sequencing) datasets.Key ResultsA high selfing rate with significantly increased homozygosity characterized the eastern lineage, associated with lower levels of visibility and herkogamy in the floral traits. The two lineages harboured independent phylogeographical histories. In contrast to the western lineage, the eastern lineage showed a gradual reduction in the effective population size with no signs of a severe bottleneck despite its extreme range contraction during the last glacial period.ConclusionsOur results suggest that the selfing-associated morphological changes in D. kiusiana are of relatively old origin (at least 100 000 years ago) and were driven by directional selection for efficient self-pollination. We provide evidence that the evolution of the selfing syndrome in D. kiusiana is not strongly associated with a severe population bottleneck.
A randomized clinical trial of isolated ambulatory phlebectomy versus saphenous thermal ablation with concomitant phlebectomy (SAPTAP Trial)
Authors: Scheerders Eveline R Y , van der Velden Simone K , Goossens Lucas M A , Hamann Sterre A S , de Maeseneer Marianne G R , Malskat Wendy S J , de Mik Linda , Nijsten Tamar E C , van den Bos Renate R ,   the members of the SAPTAP group, Scheerders E R Y , Hamann S A S , Malskat W S J , Maeseneer de M G R , Bos van den R R , Velden van der S K , Mik de L , Gaastra M T W , Koppen S , Roos De K P , Shadid N H , Wolff O 
Published: December 2022

Abstract

Background
Current treatment of patients with saphenous trunk and tributary incompetence consists of truncal ablation with concomitant, delayed or no treatment of the tributary. However, reflux of the saphenous trunk may be reversible after treatment of the incompetent tributary. The aim of this study was to determine whether single ambulatory phlebectomy with or without delayed endovenous truncal ablation (SAP) is non-inferior to thermal endovenous ablation with concomitant phlebectomy (TAP), and whether SAP is a cost-effective alternative to TAP.

Methods
A multicentre, non-inferiority RCT was conducted in patients with an incompetent great saphenous vein or anterior accessory saphenous vein with one or more incompetent tributaries. Participants were randomized to receive SAP or TAP. After 9 months, additional truncal treatment was considered for SAP patients with remaining symptoms. The primary outcome was VEnous INsufficiency Epidemiological and Economic Study Quality of Life/Symptoms (VEINES-QOL/Sym score) after 12 months. Secondary outcomes were, among others, cost-effectiveness, perceived improvement of symptoms, and anatomical success.

Results
Some 464 patients received the allocated treatment (SAP 227, TAP 237). VEINES-QOL scores were 52.7 (95 per cent c.i. 51.9 to 53.9) for SAP and 53.8 (53.3 to 55.1) for TAP; VEINES-Sym scores were 53.5 (52.6 to 54.4) and 54.2 (54.0 to 55.6) respectively. Fifty-eight patients (25.6 per cent) in the SAP group received additional truncal ablation. Treatment with SAP was less costly than treatment with TAP.

Conclusion
One year after treatment, participants who underwent SAP had non-inferior health-related quality of life compared with those who had TAP. Treatment with SAP was a cost-effective alternative to TAP at 12 months.

Registration number
NTR 4821 (www.trialregister.nl).
Olfaction in pregnancy: systematic review and meta-analysis
Authors: Albaugh Shaley L , Wu Lisa L , Zhang Douglas , Diaz Ashley , Werner Debra A , Pinto Jayant M , Cameron E Leslie 
Published: December 2022

Abstract
Little attention has been paid to olfactory changes during pregnancy with contemporary studies limited in number and sample size. We examined whether pregnancy is associated with differences in olfactory performance and if there were any specific gestational ages at which these differences occur through a comprehensive systematic review and meta-analysis of the current literature. An initial electronic database search identified 234 citations, which were screened at the abstract level. Twenty-three citations were germane for full-text review, and 13 met criteria for inclusion. Our review assessed 5 olfactory measures of interest: odor identification (n = 11 articles), threshold (n = 8), discrimination (n = 5), hedonics (n = 6), and intensity (n = 5). Nine of these 13 studies contained sufficient data for meta-analysis, and these studies included a total of 523 pregnant women and 365 non-pregnant controls. Despite previous subjective and objective reports of odor intolerances and odor hypersensitivity, we did not find any significant differences between pregnant and non-pregnant women in odor discrimination, thresholds, or hedonics. However, meta-analysis of 506 cases and 333 controls showed worse odor identification in pregnant women compared to controls in a random-effects model. Thus, we demonstrate worse performance at odor identification during pregnancy. In this review, we discuss the current evidence (and lack thereof) regarding olfaction in pregnancy as well as highlight current knowledge gaps in this field.
Development and Validation of Stability-Indicating High-Performance Liquid Chromatography Method for Estimation of Lacosamide in Bulk and Its Pharmaceutical Dosage Form
Authors: Padhiyar Shantilal , Jivani Kamlesh M , Upadhyay Jagat , Patel Tejas , Suhagia Bhanubhai 
Published: December 2022

Abstract
A simple, specific, accurate and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the determination of lacosamide, using C18 column and a mobile phase composed of phosphate buffer (pH 4.0):acetonitrile (40:60 v/v). The retention time of lacosamide was found to be 2.7 min. Linearity was established for lacosamide in the range of 10–50 μg/mL. The percentage recovery of lacosamide was found to be in the range of 97.37–99.20%. The drug was subjected to acid, alkali, oxidation, dry heat and photolytic degradation. The degradation studies indicated condition was well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for quantitative analysis of lacosamide in bulk drug and formulation.
Cardiovascular surgery in very low birth weight (≤1500 g) neonates
Authors: Henmi Soichiro , Essa Yasin , Öztürk Mahmut , Tongut Aybala , Desai Manan , Yerebakan Can , d’Udekem Yves 
Published: December 2022

Abstract

OBJECTIVES
Low birth weight and prematurity are known risks of increased morbidity and mortality with undergoing cardiovascular surgery. Our aim was to review the outcomes of very low birth weight (≤1500 g) patients who have undergone cardiovascular surgery.

METHODS
A retrospective review was performed for 32 very low birth weight (≤1500 g) patients who underwent cardiovascular surgery from 2004 to 2021 in our institution.

RESULTS
Fifteen patients weighting ≤1500 g at surgery (≤1500-g group) were compared to 17 patients born with a weigh of ≤1500 g and weighting between 1500 and 2500 g at surgery (&gt;1500- to ≤2500-g group) in this study. In-hospital mortality was 33% (5/15) in the ≤1500-g group and 24% (4/17) in the &gt;1500- to ≤2500-g group (P = 0.55). All patients with simple biventricular lesion survived following full repair. The occurrence of postoperative intracerebral haemorrhage was significantly higher in those operated at weight ≤1500 g than those weighting &gt;1500 to ≤2500 g (40% vs 0%; P = 0.01). The 1- and 3-year survival rates were 66.0 ± 12.4% and 46.2 ± 14.8% in the ≤1500-g group and 76.5 ± 10.3% and 70.6 ± 11.1% in the &gt;1500- to ≤2500-g group (log-rank P = 0.12).

CONCLUSIONS
Cardiac surgery for a very low birth weight neonate resulted in a high early and late mortality. Early surgery is only acceptable for simple biventricular lesions if needed. Delayed surgery seems to provide better long-term outcomes in patients with complex lesions. Alternative strategies for neonatal cardiopulmonary bypass should be investigated in patients with complex biventricular and single ventricular lesions.
Sustaining telehealth among cardiac and pulmonary rehabilitation services: a qualitative framework study
Authors: Thomas Emma E , Chambers Rebecca , Phillips Samara , Rawstorn Jonathan C , Cartledge Susie 
Published: December 2022

Abstract

Aims
As we move into a new phase of the COVID-19 pandemic, cardiac and pulmonary services are considering how to sustain telehealth modalities long-term. It is important to learn from services that had greater telehealth adoption and determine factors that support sustained use. We aimed to describe how telehealth has been used to deliver cardiac and pulmonary rehabilitation services across Queensland, Australia.

Methods and results
Semi-structured interviews (n = 8) and focus groups (n = 7) were conducted with 27 cardiac and pulmonary clinicians and managers from health services across Queensland between June and August 2021. Interview questions were guided by Greenhalgh’s Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework. Hybrid inductive/deductive framework analysis elicited six main themes: (i) Variable levels of readiness; (ii) Greater telehealth uptake in pulmonary vs. cardiac rehabilitation; (iii) Safety and risk management; (iv) Client willingness—targeted support required; (v) Equity and access; and (vi) New models of care. We found that sustained integration of telehealth in cardiac and pulmonary rehabilitation will require contributions from all stakeholders: consumers (e.g. co-design), clinicians (e.g. shared learning), health services (e.g. increasing platform functionality), and the profession (e.g. sharing resources).

Conclusion
There are opportunities for telehealth programmes servicing large geographic areas and opportunities to increase programme participation rates more broadly. Centralized models of care serving large geographic areas could maximize sustainability with current resource limitations; however, realizing the full potential of telehealth will require additional funding for supporting infrastructure and workforce. Individuals and organizations both have roles to play in sustaining telehealth in cardiac and pulmonary services.
How Do Own and Siblings’ Genders Shape Caregivers’ Risk of Perceiving Care-Related Criticism From Siblings?
Authors: Rurka Marissa M , Suitor J Jill , Gilligan Megan , Frase Robert T 
Published: December 2022

AbstractObjectivesCaring for a parent takes a greater psychological toll on daughters than sons. To minimize the psychological burden of parent care, it is important to understand what contributes to this gender disparity. Inspired by the caregiver stress process model and gender-as-relational perspective, we investigate how caregivers’ gender, and the genders of their siblings, shape their risk of perceiving care-related criticism from siblings, a secondary stressor of caregiving with negative implications for psychological well-being.MethodsUsing data from 408 adult child caregivers nested within 231 families collected as part of the Within-Family Differences Study, we employ multilevel modeling to examine how caregivers’ gender, as well as the gender composition of their sibship, interact to shape caregivers’ probability of perceiving criticism from siblings regarding the care that they provide their mother. Qualitative data from the same caregivers are then analyzed to illuminate processes underlying these statistical associations.ResultsQuantitative analyses reveal that daughters in predominantly-son sibships have a lower risk of perceiving care-related criticism than daughters in sibships with higher proportions of daughters. Qualitative analyses elucidate these findings. Daughters in predominantly-son sibships report that their siblings defer to them regarding their mother’s care. Conversely, daughters in higher proportion-daughter sibships perceive care-related criticism because they and their sibling(s) hold conflicting views regarding care, and there is less consensus regarding who best understands their mother’s care needs and preferences.DiscussionFindings demonstrate how characteristics of caregivers and their sibships interact to affect caregivers’ risk of perceiving criticism regarding their care to their mothers.
The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways
Authors: Nakahama Taisuke , Kawahara Yukio 
Published: December 2022

AbstractAdenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme that catalyzes adenosine-to-inosine conversions in double-stranded RNAs (dsRNAs). In mammals, ADAR1 is composed of two isoforms: a nuclear short p110 isoform and a cytoplasmic long p150 isoform. Whereas both isoforms contain right-handed dsRNA-binding and deaminase domains, ADAR1 p150 harbors a Zα domain that binds to left-handed dsRNAs, termed Z-RNAs. Myeloma differentiation-associated gene 5 (MDA5) sensing of endogenous dsRNAs as non-self leads to the induction of type I interferon (IFN)-stimulated genes, but recent studies revealed that ADAR1 p150-mediated RNA editing, but not ADAR1 p110, prevents this MDA5-mediated sensing. ADAR1 p150-specific RNA-editing sites are present and at least a Zα domain–Z-RNA interaction is required for this specificity. Mutations in the ADAR1 gene cause Aicardi–Goutières syndrome (AGS), an infant encephalopathy with type I IFN overproduction. Insertion of a point mutation in the Zα domain of the Adar1 gene induces AGS-like encephalopathy in mice, which is rescued by concurrent deletion of MDA5. This finding indicates that impaired ADAR1 p150-mediated RNA-editing is a mechanism underlying AGS caused by an ADAR1 mutation. ADAR1 p150 also prevents ZBP1 sensing of endogenous Z-RNA, which leads to programmed cell death, via the Zα domain and its RNA-editing activity. Furthermore, ADAR1 prevents protein kinase R (PKR) sensing of endogenous right-handed dsRNAs, which leads to translational shutdown and growth arrest. Thus, ADAR1 acts as a regulatory hub that blocks sensing of endogenous dsRNAs as non-self by multiple sensor proteins, both in RNA editing-dependent and -independent manners, and is a potential therapeutic target for diseases, especially cancer.
POPDx: an automated framework for patient phenotyping across 392 246 individuals in the UK Biobank study
Authors: Yang Lu , Wang Sheng , Altman Russ B 
Published: December 2022

AbstractObjectiveFor the UK Biobank, standardized phenotype codes are associated with patients who have been hospitalized but are missing for many patients who have been treated exclusively in an outpatient setting. We describe a method for phenotype recognition that imputes phenotype codes for all UK Biobank participants.Materials and MethodsPOPDx (Population-based Objective Phenotyping by Deep Extrapolation) is a bilinear machine learning framework for simultaneously estimating the probabilities of 1538 phenotype codes. We extracted phenotypic and health-related information of 392 246 individuals from the UK Biobank for POPDx development and evaluation. A total of 12 803 ICD-10 diagnosis codes of the patients were converted to 1538 phecodes as gold standard labels. The POPDx framework was evaluated and compared to other available methods on automated multiphenotype recognition.ResultsPOPDx can predict phenotypes that are rare or even unobserved in training. We demonstrate substantial improvement of automated multiphenotype recognition across 22 disease categories, and its application in identifying key epidemiological features associated with each phenotype.ConclusionsPOPDx helps provide well-defined cohorts for downstream studies. It is a general-purpose method that can be applied to other biobanks with diverse but incomplete data.
Morphology and Distribution of Antennal Sensilla in an Egg Parasitoid Wasp,Anastatus disparis(Hymenoptera: Eupelmidae)
Authors: Wang Jianjun , Liu Pengcheng , Wang Jianguo , Luan Qingshu , Jiang Xu , Cao Chuanwang 
Published: December 2022

AbstractThe wasp Anastatus disparis is an egg endoparasitoid of a number of Lepidopteran pest species. To better understand the A. disparis olfactory system, we observed the antennal sensilla of males and females under a scanning electron microscope and quantified their sizes and morphological characteristics. We identified the types of sensilla and counted the numbers and locations of the different types on the dorsal and ventral antennal surfaces. The antennae of A. disparis are geniculate, with flagella that comprise 11 subsegments in females and eight in males. The mean antenna length was 1324.10 ± 52.50 μm in females and 1323.93 ± 65.20 μm in males. Ten sensillum types were identified in both sexes: Böhm bristles (BBs), sensilla trichodea (ST, with subtypes STI and STII), sensilla chaetica (SCh), sensilla basiconica (SB, with subtypes SBI and SBII), sensilla placodea (SP), sensilla coeleoconica (SCo), sensilla grooved peg (SGP), sensilla auricillica (SAu), sensilla campaniformia (SCa), and glandular pores (GPs). The total numbers of BBs, STI, SBII, SCa, SCo, and GPs did not differ significantly between the sexes, whereas the total numbers of SCh, SBI, and SAu were significantly greater in females, and those of STII, SP, and SGP were significantly lower. The types, number, and density of antennal sensilla increased from the base to the end. The possible functions of these sensilla in host-detection behavior are discussed.