bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photo‐Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles
Authors: Perez Schmidt Patricia , Pagano Katiuscia , Lenardi Cristina , Penconi Marta , Ferrando Ruth Mateu , Evangelisti Claudio , Lay Luigi , Ragona Laura , Marelli Marcello , Polito Laura 
Published: November 2022

AbstractUltra‐small gold nanoparticles (UAuNPs) are extremely interesting for applications in nanomedicine thanks to their good stability, biocompatibility, long circulation time and efficient clearance pathways. UAuNPs engineered with glycans (Glyco‐UAuNPs) emerged as excellent platforms for many applications since the multiple copies of glycans can mimic the multivalent effect of glycoside clusters. Herein, we unravel a straightforward photo‐induced synthesis of Glyco‐UAuNPs based on a reliable and robust microfluidic approach. The synthesis occurs at room temperature avoiding the use of any further chemical reductant, templating agents or co‐solvents. Exploiting 1H NMR spectroscopy, we showed that the amount of thiol‐ligand exposed on the UAuNPs is linearly correlated to the ligand concentration in the initial mixture. The results pave the way towards the development of a programmable synthetic approach, enabling an accurate design of the engineered UAuNPs or smart hybrid nano‐systems.
Reticular Synthesis of One‐Dimensional Covalent Organic Frameworks with 4‐c sql Topology for Enhanced Fluorescence Emission
Authors: Chen Ziao , Wang Kai , Tang Yumeng , Li Lan , Hu Xuening , Han Mingxi , Guo Zhiyong , Zhan Hongbing , Chen Banglin 
Published: November 2022

AbstractCovalent organic frameworks (COFs) have been extensively investigated due to their unique structure, porosity, and functionality. However, at the topological level, COFs remain as two‐dimensional (2D) or three‐dimensional (3D) structures, while COFs with one‐dimensional (1D) topology have not been systematically explored. In this work, we proposed a synthetic strategy for the construction of 1D‐COFs based on non‐linear edges and suitable high‐symmetry vertices. Compared with their 2D‐COFs counterparts, the 1D‐COFs with AIEgens located at the vertex of the frame exhibited enhanced fluorescence. The density functional theory (DFT) calculations revealed that the dimensional‐induced rotation restriction (DIRR) effect could spontaneously introduce additional non‐covalent interactions between the strip frames, which could substantially diminish non‐radiative transitions. This work also provides protocols for the design of 1D‐COFs and a guidance scheme for the synthesis of emitting COFs.
Origin and Acceleration of Insoluble Li2S2−Li2S Reduction Catalysis in Ferromagnetic Atoms‐based Lithium‐Sulfur Battery Cathodes
Authors: Yan Rui , Zhao Zhenyang , Cheng Menghao , Yang Zhao , Cheng Chong , Liu Xikui , Yin Bo , Li Shuang 
Published: November 2022

AbstractAccelerating insoluble Li2S2−Li2S reduction catalysis to mitigate the shuttle effect has emerged as an innovative paradigm for high‐efficient lithium‐sulfur battery cathodes, such as single‐atom catalysts by offering high‐density active sites to realize in situ reaction with solid Li2S2. However, the profound origin of diverse single‐atom species on solid‐solid sulfur reduction catalysis and modulation principles remains ambiguous. Here we disclose the fundamental origin of Li2S2−Li2S reduction catalysis in ferromagnetic elements‐based single‐atom materials to be from their spin density and magnetic moments. The experimental and theoretical studies disclose that the Fe−N4‐based cathodes exhibit the fastest deposition kinetics of Li2S (226 mAh g−1) and the lowest thermodynamic energy barriers (0.56 eV). We believe that the accelerated Li2S2−Li2S reduction catalysis enabled via spin polarization of ferromagnetic atoms provides practical opportunities towards long‐life batteries.
The effect of process parameters on the properties of elastic melt blown nonwovens: Air pressure and DCD
Authors: Chang Li , Zhou Yanfen , Dai Kun , Jiang Liang , Jerrams Stephen , Ma Jianwei , Chen Shaojuan 
Published: November 2022

AbstractAn elastic masterbatch and elastic melt blown nonwovens are prepared based successively on styrene‐ethylene/butylene‐styrene (SEBS) and polypropylene (PP) blend. The phase separation morphology, rheological properties and crystal structure of the elastic masterbatch are investigated. The results show that a compatible and stable structure is obtained in molten SEBS and PP blend with excellent mobility in the temperature range of 210–230°C. The crystallization of PP slows down resulting in a finer structure due to the restriction of the SEBS network structure with rarely change of crystalline structure. The relationship between process parameters and properties of the elastic nonwoven is also studied in detail. Air pressure and die to collector distance (DCD) have discernible effects on fiber diameter and bonding between fibers, further influencing the performances of nonwovens including porosity, tensile strength and elastic recovery. Elastic recovery is shown to be significantly more affected by DCD than by air pressure.
Dynamics of DNA Through Solid‐state Nanopores Fabricated by Controlled Dielectric Breakdown
Authors: Fujinami Tanimoto Izadora Mayumi , Zhang Jiayi , Cressiot Benjamin , Le Pioufle Bruno , Bacri Laurent , Pelta Juan 
Published: November 2022

AbstractControlled dielectric breakdown (CDB) is gaining popularity for fabricating solid‐state nanopores in situ with size control in a simple, low‐cost, and scalable way. This technique could be used for a broad type of applications in the field of nucleic acid analysis and even for protein studies. In this work, we studied the entry and transport of double‐stranded DNAs using a solid‐state nanopore fabricated by CDB as a function of applied voltage for two different DNA lengths. We showed that the blockade rate increases exponentially with voltage up to 120 mV. The energy barrier depends on the chain length, and the dwell times decrease with applied voltage up to 120 mV. Moreover, no matter the chain length, it is possible to differentiate two families of blockade amplitudes, high and low ones, due to DNA folding.
Ugi Cascade Sequence for the Construction of 3‐Pyrrolin‐2‐one Scaffolds: Anti‐proliferation in Prostate Cancer Cells
Authors: Lei Jie , Yang Dong‐Lin , Xu Jia , Li Jie , Zhang Geng‐Yuan , Xiong Xu , Zhou Chen‐He , Xu Zhi‐Gang , Chen Zhong‐Zhu 
Published: November 2022

AbstractHerein, a small series of 3‐pyrrolin‐2‐ones was efficiently synthesized through a three‐step Ugi cascade sequence. This method features readily available substrates, simple aqueous workup procedures and good yields, dramatically improving generality of reaction. Importantly, the newly product N‐benzyl‐2‐(3‐(4‐chlorophenyl)‐4‐methyl‐2‐oxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)‐2‐phen‐ylacetamide exhibited potent anti‐proliferation in prostate cancer cell line through G1/S cell cycle arrest and targeted in PI3K/AKT/TSC2 signal pathway.
Valence‐variable Catalysts for Redox‐controlled Switchable Ring‐opening Polymerization
Authors: Li Bokun , Hu Chenyang , Pang Xuan , Chen Xuesi 
Published: November 2022

AbstractAs a representative class of sustainable polymer materials, biodegradable polymers have attracted increasing interest in recent years. Despite significant advance of related polymerization techniques, realizing high sequence‐control and easy‐handling in ring‐opening (co)polymerizations still remains a central challenge. To this end, a promising solution is the development of valence‐variable metal‐based catalysts for redox‐induced switchable polymerization of cyclic esters, cyclic ethers, epoxides, and CO2. Through a valence‐determined electron effect, the switch between different catalytically active states as well as dormant state contributes to convenient formation of polymer products with desired microstructures and various practical performances. This redox‐controlled switchable strategy for controlled synthesis of polymers is overviewed in this Review with a focus on potential applications and challenges for further studies.
Discussion of “Multivariate Dynamic Modeling for Bayesian Forecasting of Business Revenue”
Authors: So Mike K.P. , Chen Cathy W.S. 
Published: November 2022

AbstractThis paper, “Multivariate Dynamic Modeling for Bayesian Forecasting of Business Revenue,” proposes a novel Bayesian approach based on dynamic linear models to share information from different sectors, LSG (Local Store Group), and item category, through the use of auxiliary information (the discount information). The authors demonstrate the feasibility of parallel computing with multiple item categories, making the Bayesian method highly scalable. The proposed method in the paper should have wide applicability in inventory and revenue management. We suggest in this discussion potential areas for further development.
Integrated Conjugated Microporous Polymers/Carbon Nanotube Composite Boosting Superior Anodic Lithium Storage Behavior
Authors: Yu Jie , Li Suriguga , Si Zhenjun , Gao Bo , Lv Xiaoling , Wang Heng‐guo 
Published: November 2022

AbstractConjugated microporous polymers (CMPs) with redox‐active sites have attracted extensive notice in rechargeable lithium‐ion batteries (LIBs) due to their extended π‐conjugated structure, uniform porosity, and low solubility. However, poor electrical conductivity and low utilization of active sites limit their application in large‐scale energy storage systems (ESS). Herein, we synthesized two carbonyl‐rich imine‐based CMPs by the polycondensation reaction between tetromino‐benzoquinone and aldehydes, and integrated them with carbon nanotubes (TB‐CMP@CNT and TBP‐CMP@CNT). The composites display good electrochemical performances as anode‐active materials of LIBs, which benefits from abundant redox‐active units, stable π‐conjugated framework, and fast Li+ diffusion kinetics. Especially, TBP‐CMP@CNT has a high reversible capacity of 954.6 mAh g−1 at 50 mA g−1, a long cycle stability at 1 A g−1 with no decrease in capacity after 1000 cycles, and superior rate performance of 221.5 mAh g−1 at 2 A g−1.
In vitro–in vivo extrapolation of bexarotene metabolism in the presence of chronic kidney disease and acute kidney injury in rat using physiologically based pharmacokinetic modeling and extrapolation to human
Authors: Alsmadi Mo'tasem M. , Alzughoul Saja B. 
Published: November 2022

AbstractRenal impairment can affect the elimination of hepatically metabolized drugs. Bexarotene (BXT) used for cutaneous T‐cell lymphoma is highly bound in plasma and metabolized by CYP3A4. The BXT European Medicine Agency and Food and Drug Administration packages recommended the evaluation of renal impairment on BXT metabolism. The plasma protein binding of BXT can be changed in patients with renal dysfunction due to hypoalbuminemia and accumulation of uremic toxins. In vitro, microsomal stability and plasma protein binding studies were pursued. A preclinical pharmacokinetic study was pursued in control, chronic kidney disease (CKD), and acute kidney injury (AKI) rats. A BXT physiologically based pharmacokinetic (PBPK) model that utilized in vitro–in vivo extrapolation of metabolism was established and verified in healthy rats, customized to CKD and AKI rats, and extrapolated to healthy human subjects and those with CKD stages 3, 4, and 5. In vitro studies showed that AKI and CKD significantly increased the BXT fraction unbound in plasma (from 0.011 to 0.018 and 0.022, respectively) and decreased intrinsic clearance (from 4.1 to 2.5, and 2.2 mL/min/g liver, respectively). This could explain the reduced in vivo clearance observed in CKD rats (from 0.4 to 0.28 L/h/kg) and the 1.3‐fold increase in BXT exposure. Changes in BXT disposition in AKI rats were not straightforward due to simultaneous changes in BXT distribution. The human PBPK model predicted an increased BXT exposure by 2‐fold in CKD patients, suggesting the need for dose reduction and drug monitoring. The reduced BXT metabolism due to renal impairment is especially relevant in cancer patients with CKD.
Galvanic replacement reaction to prepare catalytic materials
Authors: Hong Yongju , Venkateshalu Sandhya , Jeong Sangyeon , Tomboc Gracita M. , Jo Jinhyoung , Park Jongsik , Lee Kwangyeol 
Published: November 2022

AbstractGalvanic replacement reaction (GRR) has gained considerable interest as a facile and versatile synthetic method for modulating compositions, morphologies, and corresponding physicochemical properties of metallic nanoparticles. Thus far, extensive knowledge of GRR on monometallic templates has been accumulated, backed with ample experimental data and computational modeling and validation. The GRR templates have recently been extended to other materials such as alloys, oxides, sulfides, and liquid metals. These new materials have demonstrated potential applications in electrochemical energy conversion systems, which have been relatively unexplored for GRR‐originated materials. In this review, the recent findings in GRR on these new template materials are introduced, pointing to the incredible versatility of the GRR methodology in diversifying the catalytic materials classes. We further discuss the remaining critical issues and future research directions of GRRs to fully exploit the potential of GRR in spearheading future advances in electrocatalytic energy conversion and other important applications.
Influences of Some Aromatic Plants on Volatile Compounds and Bioactivity of Cultivated Pleurotus citrinopileatus and Pleurotus djamor
Authors: Süfer Özge , Çelik Zeynep Dilan , Bozok Fuat 
Published: November 2022

AbstractTwo edible Pleurotus species, namely, Pleurotus citrinopileatus and Pleurotus djamor grown in the media of mulberry shavings which were substituted with myrtle, bay laurel, and rosemary leaves were studied. According to volatile profiles, 13 aldehydes, 8 ketones, 7 alcohols, 5 aromatic compounds and 4 terpenes were totally identified. Rosemary leaves were very effective for decreasing the concentrations of some oxidation products in Pleurotus citrinopileatus, but the same impact was not seen in Pleurotus djamor. The high amount of benzaldehyde (41.80 %) detected in bay laurel medium might have played a role in preventing bioactivity. Control Pleurotus citrinopileatus and Pleurotus djamor had a total phenolic content of 4284.89 and 3080.04 mg GAE per kg DM, respectively, and the enrichment of composts with aromatic plant leaves caused significant differences in Pleurotus djamor (p<0.05). Myrtle addition increased total phenolic content and antioxidant activities (by DPPH and FRAP assays) of Pleurotus djamor mushroom as 342.29 mg GAE/kg DM, 0.43 μmol TE/g DM and 2.07 μmol TE/g DM, respectively, when compared to intact one.
Optimization of RiPCA for the Live‐Cell Detection of Pre‐MicroRNA‐Protein Interactions
Authors: Rosenblum Sydney L. , Garner Amanda L. 
Published: November 2022

AbstractAdvancements in methods for identifying RNA‐protein interactions (RPIs) on a large scale has necessitated the development of assays for validation of these interactions, particularly in living cells. We previously reported the development of RiPCA (RNA interaction with protein‐mediated complementation assay) to enable the cellular detection of the well‐characterized interaction between the pre‐microRNA, pre‐let‐7, and its RNA‐binding protein (RBP) partner Lin28. In this study, the applicability of RiPCA for the detection of putative pre‐miRNA‐protein interactions was explored using an improved RiPCA protocol, termed RiPCA 2.0. RiPCA 2.0 was adapted to detect the sequence specificity of the RBPs hnRNP A1, Msi1, and Msi2 for reported pre‐microRNA binding partners. Additionally, the ability of RiPCA 2.0 to detect site‐specific binding was explored. Collectively, this work highlights the versatility of RiPCA 2.0 in detecting cellular RPIs.
Stent expansion of restrictive Fontan conduits to nominal diameter and beyond
Authors: Salaets Thomas , Cools Bjorn , De Meester Pieter , Heying Ruth , Boshoff Derize , Eyskens Benedicte , Brown Stephen , Meyns Bart , Rega Filip , Van Puyvelde Joeri , Budts Werner , Gewillig Marc 
Published: November 2022

AbstractBackgroundMechanical factors may cause bottlenecks in a Fontan circuit. Extracardiac conduits (ECC) are placed at a young age, but the materials do not allow growth. Restriction in ECC dimensions may deteriorate the function of the circuit.AimsThis study aimed to evaluate the feasibility and safety of stent expansion of an ECC to the nominal dimension at the time of implant and, if possible, beyond nominal.MethodsRetrospective, single‐center observational review of all ECC Fontan patients who received a stent to expand a previously placed surgical conduit.ResultsA total of 44 restrictive conduits were stented over a 14‐year study period with a median of 11.8 (interquartile ranges [IQR]: 9.1−13.8) years after ECC placement. Cross‐sectional areas were a median of 30% (IQR: 21−42) smaller than the originally placed ECC; there was no gradient in 23/44 patients and in 21/44, a minimal gradient of 1.3 ± 0.5 (range 1−3 mmHg). All conduits could be enlarged with a significant (p < 0.0001) increase in diameter from 13.6 ± 1.8 to 19.2 ± 1.2 mm, corresponding to a median cross‐sectional area increase of 171% (IQR: 153−220). In three patients where the conduits were not contracted, expansion of between 127% and 165% was obtained. There were no conduit ruptures and only one minor complication.ConclusionsECC in some Fontan patients become smaller than nominal over time, usually without overt symptoms. The dimensions of ECC's can be safely and significantly increased to nominal or even beyond employing stenting. It allows adjustment of ECC dimensions to compensate for somatic growth.
Selective Photocatalytic Reduction of CO2‐to‐CO in Water using a Polymeric Carbon Nitride Quantum Dot/Fe‐Porphyrin Hybrid Assembly
Authors: Mistry Liam , Le‐Quang Long , Masdeu Gerard , Björkman Wilma , Härelind Hanna , Abrahamsson Maria 
Published: November 2022

AbstractVisible light‐driven conversion of CO2 into more value‐added products is a promising technology not only for diminution of CO2 emission but also for solar energy storage in the form of chemical energy. However, photocatalytic materials that can efficiently and selectively reduce CO2‐to‐CO in a fully aqueous solution typically involve precious metals that limit their suitability for large scale applications. Herein, a novel photocatalytic assembly is reported, consisting of polymeric carbon nitride quantum dots (CNQDs) as the visible light absorber and a Fe‐porphyrin complex (Fe‐p‐TMA) as the catalyst for CO2‐to‐CO conversion. Both components were carefully selected to allow for excellent solubility in water as well as improved electronic communication through complementary electrostatic and π‐π interactions. This CNQD ⋅ [Fe‐p‐TMA] hybrid assembly, at the optimized molar ratio, can produce CO with a turnover number (TON) exceeding 105 and selectivity ∼96 % after 10 hours of visible light irradiation (400–700 nm). It is postulated that the enhanced CO2‐to‐CO transformation performance is due to the convenience of a more direct charge transfer (CT) pathway between the CNQDs and [Fe‐p‐TMA] motif.
Optimizing band structure of CoP nanoparticles via rich‐defect carbon shell toward bifunctional electrocatalysts for overall water splitting
Authors: Wu Juncheng , Wang Zhe‐Fan , Guan Taotao , Zhang Guoli , Zhang Juan , Han Jie , Guan Shengqin , Wang Ning , Wang Jianlong , Li Kaixi 
Published: November 2022

AbstractTransition‐metal phosphides (TMPs) with high catalytic activity are widely used in the design of electrodes for water splitting. However, a major challenge is how to achieve the trade‐off between activity and stability of TMPs. Herein, a novel method for synthesizing CoP nanoparticles encapsulated in a rich‐defect carbon shell (CoP/DCS) is developed through the self‐assembly of modified polycyclic aromatic molecules. The graft and removal of high‐activity C–N bonds of aromatic molecules render the controllable design of crystallite defects of carbon shell. The density functional theory calculation indicates that the carbon defects with unpaired electrons could effectively tailor the band structure of CoP. Benefiting from the improved activity and corrosion resistance, the CoP/DCS delivers outstanding difunctional hydrogen evolution reaction (88 mV) and oxygen evolution reaction (251 mV) performances at 10 mA cm−2 current density. Furthermore, the coupled water electrolyzer with CoP/DCS as both the cathode and anode presents ultralow cell voltages of 1.49 V to achieve 10 mA cm−2 with long‐time stability. This strategy to improve TMPs electrocatalyst with rich‐DCS and heterogeneous structure will inspire the design of other transition metal compound electrocatalysts for water splitting.
Enhancing Resistance to Chloride Corrosion by Controlling the Morphologies of PtNi Electrocatalysts for Alkaline Seawater Hydrogen Evolution
Authors: Zhang Xue‐Qi , Xiao Yu‐Xuan , Tian Ge , Yang Xiong , Dong Yuan , Zhang Fan , Yang Xiao‐Yu 
Published: November 2022

AbstractA solvothermal method to prepare PtNi alloys that have differing morphologies is described. By adjusting the feed ratio of Pt and Ni precursors in this process, PtNi alloys with different compositions (Pt : Ni atomic ratio from 1 : 3 to 3 : 1) and morphologies (evolution from nanobranches to nanoparticles) are generated. The prepared Pt48Ni52 alloy, which has a composite morphology comprised of nanobranches and nanoparticles, exhibits superior activity and durability towards the hydrogen evolution reaction (HER) in seawater compared to those of commercial Pt/C catalyst and other PtNi alloys that have different compositions and morphologies. The excellent seawater HER performance of Pt48Ni52 is ascribed to its nanobranch/nanoparticle morphology that optimally facilitates electron accumulation on Pt, which enhances resistance to chloride corrosion in seawater.
In situ Self‐Catalyzed Growth of Manganese‐Embedded 3D Flakes‐Coated Carbon Rod as an Efficient Oxygen‐Reduction Reaction Catalyst of Zinc‐Air Batteries
Authors: Zhang Shuangshuang , Hou Jin‐an , Hu Juan , Zhang Chun‐yang 
Published: November 2022

AbstractThe in situ self‐catalyzed growth of manganese‐embedded 3D flakes‐coated carbon rods (GFC) as an efficient oxygen‐reduction reaction (ORR) catalyst of Zinc‐air batteries is described for the first time. By optimizing the amount of Mn in the precursor, a series of 3D graphene‐like flakes‐coated carbon rods were synthesized. GFC with a doping amount of Mn of 10 % (GFC‐10) exhibits excellent ORR performance with an onset potential of 0.94 V (vs. reversible hydrogen electrode). The Zinc‐air battery is constructed with GFC‐10 as the cathode catalyst, and it exhibits a peak power density of 128.9 mW cm−2and a cycling stability of 75 h at a current density of 10 mA cm−2, which are superior to the commercial 20 wt% Pt/C‐based Zinc‐air battery. Interestingly, the introduction of Mn facilitates the self‐catalyzed growth of carbon rods, and the change of Mn amount can effectively regulate the morphology of materials. The improved ORR performance of the catalyst is ascribed to the synergistic effect of unique hierarchical porous structure, high‐charge transport capacity, abundant carbon defects/edges and Mn‐Nxsites. This research provides a new avenue to fabricating highly active Mn‐based electrocatalysts for renewable energy systems.