bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weight gain is associated with shorter lifespan: a longitudinal study of New Zealand soldiers serving in both world wars
Authors: Miecznikowski Monica , Roberts Evan 
Published: January 2022

AbstractObesity is an increasing public health concern with important mortality consequences. Weight gain or maximum adult BMI, not BMI at one point in time, has been shown to be an important risk factor in cohorts studied recently during an era of rapid increase in population levels of overweight and obesity. However, there is limited evidence on individual weight trajectories from cohorts born before the mid-twentieth century. Archival world war military personnel files from New Zealand are freely available online, and identify service in both wars. A pilot study of 316 soldiers confirmed the files contain sufficient information to examine health trajectories and lifespan. Because this cohort are now entirely deceased, nearly the entire sample can be found in death records to estimate the impact of weight increases on lifespan. Weight change over 20–30 years and its relationship with lifespan is examined using ordinary least squares regression. The study demonstrates that military records are a feasible source for collecting data on adult weight and health trajectories in the first half of the twentieth century. Although this sample is likely to be composed of men fitter than average, there is a clear pattern of increasing weight from early to mid-adulthood. Weight gain from early adulthood to middle-age was found to be more strongly associated with mortality than weight in early adulthood. A one unit increase in BMI over the inter-war period was found to be associated with an 8 month decline in lifespan. These results confirm that weight gain in adulthood has an important impact on mortality in an earlier birth cohort than previously studied, and that data exist to measure any changes more precisely over time.
A survey of the extraction and applications of causal relations
Authors: Drury Brett , Gonçalo Oliveira Hugo , de Andrade Lopes Alneu 
Published: January 2022

AbstractCausationin written natural language can express a strong relationship between events and facts. Causation in the written form can be referred to as a causal relation where a cause event entails the occurrence of an effect event. A cause and effect relationship is stronger than a correlation between events, and therefore aggregated causal relations extracted from large corpora can be used in numerous applications such as question-answering and summarisation to produce superior results than traditional approaches. Techniques like logical consequence allow causal relations to be used in niche practical applications such as event prediction which is useful for diverse domains such as security and finance. Until recently, the use of causal relations was a relatively unpopular technique because the causal relation extraction techniques were problematic, and the relations returned were incomplete, error prone or simplistic. The recent adoption of language models and improved relation extractors for natural language such as Transformer-XL (Daiet al. (2019).Transformer-xl: Attentive language models beyond a fixed-length context. arXiv preprintarXiv:1901.02860) has seen a surge of research interest in the possibilities of using causal relations in practical applications. Until now, there has not been an extensive survey of the practical applications of causal relations; therefore, this survey is intended precisely to demonstrate the potential of causal relations. It is a comprehensive survey of the work on the extraction of causal relations and their applications, while also discussing the nature of causation and its representation in text.
China and Peacekeeping: Unfolding the Political and Legal Complexities of an Ambivalent Relationship
Authors: BARELLI Mauro 
Published: January 2022

AbstractIn the past decade China's engagement with UN peacekeeping has intensified. In particular, Beijing has supported and participated in peace operations that were not fully compatible with the consensual, impartial, and non-coercive models of peacekeeping traditionally employed by the United Nations. China's endorsement of offensive and intrusive missions is not inconsequential, given that it clashes with its professed adherence to rigid interpretations of the principles of sovereignty, non-intervention, and the non-use of force in international relations. This article suggests that to make sense of China's involvement in unconventional peacekeeping operations one must examine the broader process of foreign policy recalibration that is redefining the interests and priorities of the country as a new great power. Furthermore, by examining China's ambivalent approach to the principles that have traditionally defined the legal framework of UN peacekeeping, this article highlights the opportunities and challenges that China will face as a provider of international security.
Voluntary workplace genomic testing: wellness benefit or Pandora’s box?
Authors: Sanghavi Kunal , Cohn Betty , Prince Anya E. R. , Feero W. Gregory , Ryan Kerry A. , Spector-Bagdady Kayte , Uhlmann Wendy R. , Lee Charles , Roberts J. Scott , Mathews Debra J. H. 
Published: January 2022

AbstractConsumer interest in genetic and genomic testing is growing rapidly, with more than 26 million Americans having purchased direct-to-consumer genetic testing services. Capitalizing on the increasing comfort of consumers with genetic testing outside the clinical environment, commercial vendors are expanding their customer base by marketing genetic and genomic testing services, including testing for pharmacogenomic and pathogenic variants, to employers for inclusion in workplace wellness programs. We describe the appeal of voluntary workplace genomic testing (wGT) to employers and employees, how the ethical, legal, and social implications literature has approached the issue of genetic testing in the workplace in the past, and outline the relevant legal landscape. Given that we are in the early stages of development of the wGT market, now is the time to identify the critical interests and concerns of employees and employers, so that governance can develop and evolve along with the wGT market, rather than behind it, and be based on data, rather than speculative hopes and fears.
Designing quantum networks using preexisting infrastructure
Authors: Rabbie Julian , Chakraborty Kaushik , Avis Guus , Wehner Stephanie 
Published: January 2022

AbstractWe consider the problem of deploying a quantum network on an existing fiber infrastructure, where quantum repeaters and end nodes can only be housed at specific locations. We propose a method based on integer linear programming (ILP) to place the minimal number of repeaters on such an existing network topology, such that requirements on end-to-end entanglement-generation rate and fidelity between any pair of end-nodes are satisfied. While ILPs are generally difficult to solve, we show that our method performs well in practice for networks of up to 100 nodes. We illustrate the behavior of our method both on randomly-generated network topologies, as well as on a real-world fiber topology deployed in the Netherlands.
A crowdsourced global data set for validating built-up surface layers
Authors: See Linda , Georgieva Ivelina , Duerauer Martina , Kemper Thomas , Corbane Christina , Maffenini Luca , Gallego Javier , Pesaresi Martino , Sirbu Flavius , Ahmed Rekib , Blyshchyk Kateryna , Magori Brigitte , Blyshchyk Volodymyr , Melnyk Oleksandr , Zadorozhniuk Roman , Mandici Marian-Traian , Su Yuan-Fong , Rabia Ahmed Harb , Pérez-Hoyos Ana , Vasylyshyn Roman , Pawe Chandra Kant , Bilous Svitlana , Kovalevskyi Serhii B. , Kovalevskyi Sergii S. , Bordoloi Kusumbor , Bilous Andrii , Panging Kripal , Bilous Valentyn , Prestele Reinhard , Sahariah Dhrubajyoti , Deka Anjan , Nath Nityaranjan , Neves Rui , Myroniuk Viktor , Karner Mathias , Fritz Steffen 
Published: January 2022

AbstractSeveral global high-resolution built-up surface products have emerged over the last five years, taking full advantage of open sources of satellite data such as Landsat and Sentinel. However, these data sets require validation that is independent of the producers of these products. To fill this gap, we designed a validation sample set of 50 K locations using a stratified sampling approach independent of any existing global built-up surface products. We launched a crowdsourcing campaign using Geo-Wiki (https://www.geo-wiki.org/) to visually interpret this sample set for built-up surfaces using very high-resolution satellite images as a source of reference data for labelling the samples, with a minimum of five validations per sample location. Data were collected for 10 m sub-pixels in an 80 × 80 m grid to allow for geo-registration errors as well as the application of different validation modes including exact pixel matching to majority or percentage agreement. The data set presented in this paper is suitable for the validation and inter-comparison of multiple products of built-up areas.
Global holiday datasets for understanding seasonal human mobility and population dynamics
Authors: Lai Shengjie , Sorichetta Alessandro , Steele Jessica , Ruktanonchai Corrine W. , Cunningham Alexander D. , Rogers Grant , Koper Patrycja , Woods Dorothea , Bondarenko Maksym , Ruktanonchai Nick W. , Shi Weifeng , Tatem Andrew J. 
Published: January 2022

AbstractPublic and school holidays have important impacts on population mobility and dynamics across multiple spatial and temporal scales, subsequently affecting the transmission dynamics of infectious diseases and many socioeconomic activities. However, worldwide data on public and school holidays for understanding their changes across regions and years have not been assembled into a single, open-source and multitemporal dataset. To address this gap, an open access archive of data on public and school holidays in 2010–2019 across the globe at daily, weekly, and monthly timescales was constructed. Airline passenger volumes across 90 countries from 2010 to 2018 were also assembled to illustrate the usage of the holiday data for understanding the changing spatiotemporal patterns of population movements.
Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases
Authors: Zhu Xiaojia , Wang Yuwei , Xiao Yujie , Gao Qianwen , Gao Li , Zhang Wenhui , Xin Xiaofeng , Chen Kesu , Srivastava Ujala , Ginjupalli Vamsi Krishna Murthy , Cupelli Michael , Lazzerini Pietro Enea , Capecchi Pier Leopoldo , Chen Long , Boutjdir Mohamed 
Published: January 2022

AbstractInflammatory diseases including COVID-19 are associated with a cytokine storm characterized by high interleukin-6 (IL-6) titers. In particular, while recent studies examined COVID-19 associated arrhythmic risks from cardiac injury and/or from pharmacotherapy such as the combination of azithromycin (AZM) and hydroxychloroquine (HCQ), the role of IL-6 per se in increasing the arrhythmic risk remains poorly understood. The objective is to elucidate the electrophysiological basis of inflammation-associated arrhythmic risk in the presence of AZM and HCQ. IL-6, AZM and HCQ were concomitantly administered to guinea pigs in-vivo and in-vitro. Electrocardiograms, action potentials and ion-currents were analyzed. IL-6 alone or the combination AZM + HCQ induced mild to moderate reduction in heart rate, PR-interval and corrected QT (QTc) in-vivo and in-vitro. Notably, IL-6 alone was more potent than the combination of the two drugs in reducing heart rate, increasing PR-interval and QTc. In addition, the in-vivo or in-vitro combination of IL-6 + AZM + HCQ caused severe bradycardia, conduction abnormalities, QTc prolongation and asystole. These electrocardiographic abnormalities were attenuated in-vivo by tocilizumab (TCZ), a monoclonal antibody against IL-6 receptor, and are due in part to the prolongation of action potential duration and selective inhibition of Na+, Ca2+ and K+ currents. Inflammation confers greater risk for arrhythmia than the drug combination therapy. As such, in the setting of elevated IL-6 during inflammation caution must be taken when co-administering drugs known to predispose to fatal arrhythmias and TCZ could be an important player as a novel anti-arrhythmic agent. Thus, identifying inflammation as a critical culprit is essential for proper management.
Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit
Authors: Liu Shizhen , Zhong Zhihua , Liu Fanna 
Published: January 2022

AbstractThis study evaluated the relationship between hyperuricemia at admission and the clinical prognosis of patients with sepsis. The data were obtained from the Intensive Care Medical Information Database III. The patients were divided into a normal serum uric acid group and a hyperuricemia group. The main outcome was 90-day mortality, and the secondary outcomes were hospital mortality, 30-day mortality, and acute kidney injury. Propensity score matching was used to balance the baseline characteristics of the groups. Our study retrospectively included 954 patients. Before and after propensity score matching, the incidence of AKI, the 30-day and 90-day mortality rates were significantly higher in the hyperuricemia group. Cox regression analysis showed that hyperuricemia was significantly associated with 90-day mortality (HR 1.648, 95% CI 1.215–2.234,p = 0.006), and hyperuricemia was significantly associated with the incidence of AKI (HR 1.773, 95% CI 1.107–2.841,p = 0.017). The Kaplan–Meier survival curve showed that the 90-day survival rate was significantly lower in the hyperuricemia group. In patients with sepsis in the intensive care unit, hyperuricemia was significantly associated with increased risk 90-day all-cause mortality and the incidence of AKI.
Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma
Authors: Quentmeier Hilmar , Geffers Robert , Hauer Vivien , Nagel Stefan , Pommerenke Claudia , Uphoff Cord C. , Zaborski Margarete , Drexler Hans G. 
Published: January 2022

AbstractOverexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. Antagonizing BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leukemia and for acute myeloid leukemia. To find additional hematologic entities with ectopic expression of BCL2 family members, we performed expression screening of cell lines applying the LL-100 panel. Anaplastic large cell lymphoma (ALCL) and primary effusion lymphoma (PEL), 2/22 entities covered by this panel, stood out by high expression of MCL1 and low expression of BCL2. The MCL1 inhibitor AZD-5991 induced apoptosis in cell lines from both malignancies, suggesting that this BH3 mimetic might be efficient as drug for these diseases. The ALCL cell lines also expressed BCLXL and BCL2A1, both contributing to survival of the cells. The combination of specific BH3 mimetics yielded synergistic effects, pointing to a novel strategy for the treatment of ALCL. The PI3K/mTOR inhibitor BEZ-235 could also efficiently be applied in combination with AZD-5991, offering an alternative to avoid thrombocytopenia which is associated with the use of BCLXL inhibitors.
Efficacy of adjuvant trastuzumab in women with HER2-positive T1a or bN0M0 breast cancer: a population-based cohort study
Authors: Ali Sanji , Hendry Jace , Le Duc , Mondal Prosanta K. , Sami Amer , Chalchal Haji , Haider Kamal , Ahmed Osama , El-Gayed Ali , Wright Philip , Pauls Mehrnoosh , Johnson Kate , Ahmed Shahid 
Published: January 2022

AbstractAdjuvant trastuzumab has been associated with superior survival in women with ≥ T1c or node-positive HER2-positive early-stage breast cancer; however, there is a lack of phase III trials in women with T1a/bN0 disease. Our study aimed to assess the outcomes of women with HER2-positive T1a/bN0 breast cancer who received adjuvant trastuzumab in Saskatchewan, Canada. We evaluated all women diagnosed with HER2-positive T1a/bN0 breast cancer in Saskatchewan between 2008 and 2017. We performed Cox proportional multivariable analysis to determine factors correlated with survival. In addition, inverse probability treatment weighting (IPTW) using propensity score was performed to assess benefit of adjuvant trastuzumab. Ninety-one eligible women with a median age of 61 years (range 30–89) were identified. Thirty-nine (43%) women received adjuvant trastuzumab. Women who received trastuzumab were younger and had a higher rate of T1b disease. Overall, 3% of women who received trastuzumab compared to 12% of women who did not receive trastuzumab developed breast cancer recurrence (p = 0.23). Five-year disease-free survival (DFS) of women who received adjuvant trastuzumab was 94.8% compared to 82.7% of women who did not receive trastuzumab (p = 0.22). Five-year overall survival was 100% of women who received trastuzumab compared to 90.4% of women who did not receive adjuvant trastuzumab (p = 0.038). In the multivariable analysis, grade III tumors were correlated with inferior DFS (hazard ratio [HR] 5.5, 95% CI [1.7–17.7]). The propensity score using the inverse probability of treatment weighting showed that lack of adjuvant trastuzumab was correlated inferior DFS, with an HR of 4 (95% CI 1.05–15.5). Women with HER2-positive T1a/bN0 breast cancer had overall low recurrence of breast cancer. However, the results of this exploratory analysis indicate that women who received adjuvant trastuzumab had better survival.
Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature
Authors: Ayan Esra , Yuksel Busra , Destan Ebru , Ertem Fatma Betul , Yildirim Gunseli , Eren Meryem , Yefanov Oleksandr M. , Barty Anton , Tolstikova Alexandra , Ketawala Gihan K. , Botha Sabine , Dao E. Han , Hayes Brandon , Liang Mengning , Seaberg Matthew H. , Hunter Mark S. , Batyuk Alexander , Mariani Valerio , Su Zhen , Poitevin Frederic , Yoon Chun Hong , Kupitz Christopher , Cohen Aina , Doukov Tzanko , Sierra Raymond G. , Dağ Çağdaş , DeMirci Hasan 
Published: January 2022

AbstractMultimeric protein assemblies are abundant in nature. Streptavidin is an attractive protein that provides a paradigm system to investigate the intra- and intermolecular interactions of multimeric protein complexes. Also, it offers a versatile tool for biotechnological applications. Here, we present two apo-streptavidin structures, the first one is an ambient temperature Serial Femtosecond X-ray crystal (Apo-SFX) structure at 1.7 Å resolution and the second one is a cryogenic crystal structure (Apo-Cryo) at 1.1 Å resolution. These structures are mostly in agreement with previous structural data. Combined with computational analysis, these structures provide invaluable information about structural dynamics of apo streptavidin. Collectively, these data further reveal a novel cooperative allostery of streptavidin which binds to substrate via water molecules that provide a polar interaction network and mimics the substrate biotin which displays one of the strongest affinities found in nature.
Plasticity in visual cortex is disrupted in a mouse model of tauopathy
Authors: Papanikolaou Amalia , Rodrigues Fabio R. , Holeniewska Joanna , Phillips Keith G. , Saleem Aman B. , Solomon Samuel G. 
Published: January 2022

AbstractAlzheimer’s disease and other dementias are thought to underlie a progressive impairment of neural plasticity. Previous work in mouse models of Alzheimer’s disease shows pronounced changes in artificially-induced plasticity in hippocampus, perirhinal and prefrontal cortex. However, it is not known how degeneration disrupts intrinsic forms of brain plasticity. Here we characterised the impact of tauopathy on a simple form of intrinsic plasticity in the visual system, which allowed us to track plasticity at both long (days) and short (minutes) timescales. We studied rTg4510 transgenic mice at early stages of tauopathy (5 months) and a more advanced stage (8 months). We recorded local field potentials in the primary visual cortex while animals were repeatedly exposed to a stimulus over 9 days. We found that both short- and long-term visual plasticity were already disrupted at early stages of tauopathy, and further reduced in older animals, such that it was abolished in mice expressing mutant tau. Additionally, visually evoked behaviours were disrupted in both younger and older mice expressing mutant tau. Our results show that visual cortical plasticity and visually evoked behaviours are disrupted in the rTg4510 model of tauopathy. This simple measure of plasticity may help understand how tauopathy disrupts neural circuits, and offers a translatable platform for detection and tracking of the disease.
How the motor system copes with aging: a quantitative meta-analysis of the effect of aging on motor function control
Authors: Zapparoli Laura , Mariano Marika , Paulesu Eraldo 
Published: January 2022

AbstractMotor cognitive functions and their neurophysiology evolve and degrade along the lifespan in a dramatic fashion. Current models of how the brain adapts to aging remain inspired primarily by studies on memory or language processes. Yet, aging is strongly associated with reduced motor independence and the associated degraded interaction with the environment: accordingly, any neurocognitive model of aging not considering the motor system is, ipso facto, incomplete. Here we present a meta-analysis of forty functional brain-imaging studies to address aging effects on motor control. Our results indicate that motor control is associated with aging-related changes in brain activity, involving not only motoric brain regions but also posterior areas such as the occipito-temporal cortex. Notably, some of these differences depend on the specific nature of the motor task and the level of performance achieved by the participants. These findings support neurocognitive models of aging that make fewer anatomical assumptions while also considering tasks-dependent and performance-dependent manifestations. Besides the theoretical implications, the present data also provide additional information for the motor rehabilitation domain, indicating that motor control is a more complex phenomenon than previously understood, to which separate cognitive operations can contribute and decrease in different ways with aging.