bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuyển chọn vi khuẩn có khả năng phân giải protein và ức chế vi khuẩn Vibrio spp. từ nước mắm truyền thống
Authors: Trần Hữu Hậu , Nguyễn Anh Việt , Hoàng Ngọc Khánh , Trương Thị Bích Vân , Nguyễn Phạm Anh Thi 
Published: October 2022

Nghiên cứu được thực hiện với mục đích phân lập và tuyển chọn dòng vi khuẩn có khả năng phân giải protein và ức chế vi khuẩn Vibrio spp. Khả năng phân giải protein được thực hiện bằng phương pháp nhỏ giọt vi khuẩn và khả năng ức chế Vibrio spp. được thực hiện bằng phương pháp khuếch tán qua giếng. Nghiên cứu đã phân lập được 10 dòng vi khuẩn từ nước mắm truyền thống, trong đó có 7 dòng có khả năng phân giải protein và 4 dòng có khả năng ức chế Vibrio spp. Dòng vi khuẩn được tuyển chọn là NM2.1 có đường kính vòng phân giải lớn và ức chế Vibrio spp. mạnh nhất trong những dòng vi khuẩn nghiên cứu. Qua quan sát hình thái khuẩn lạc, hình thái tế bào và giải trình tự đoạn gene 16S rDNA đã xác định được dòng NM2.1 là Bacillus sp. với độ tương đồng là 99,71% và có khả năng chịu mặn đến 25 ‰.
Các yếu tố giá trị thương hiệu ảnh hưởng đến quyết định mua sắm của người tiêu dùng: Trường hợp các siêu thị bán lẻ thương hiệu việt ở Đồng bằng sông Cửu Long
Authors: Trần Hồng Minh Ngọc , Lưu Thanh Đức Hải 
Published: October 2022

Mục tiêu của bài viết nhằm đo lường mức độ ảnh hưởng của các yếu tố giá trị thương hiệu đến quyết định mua sắm của người tiêu dùng tại các siêu thị bán lẻ thương hiệu Việt ở đồng bằng Sông Cửu Long (ĐBSCL). Mô hình lý thuyết được xây dựng dựa trên việc kế thừa mô hình của Aaker (1991) bao gồm: nhận biết thương hiệu, liên tưởng thương hiệu, trung thành thương hiệu, chất lượng cảm nhận, giá trị thương hiệu khác, quyết định mua. Kết quả nghiên cứu từ việc khảo sát 504 người tiêu dùng theo phương pháp chọn mẫu hạn mức cho thấy cả 5 yếu tố cấu thành giá trị thương hiệu đều có ý nghĩa thống kê. Trong đó, nhận biết thương hiệu là yếu tố có tác động mạnh nhất đến quyết định mua. Kết quả nghiên cứu đã cung cấp cho các nhà quản trị siêu thị thương hiệu Việt cái nhìn chi tiết về sự tác động của các yếu tố cấu thành giá trị thương hiệu đến quyết định mua của người tiêu dùng để từ đó có những chiến lược quản trị thương hiệu phù hợp.
Clinical Experience of Alpha 1 Antitrypsin (AAT) Treatment in Pediatric Patients with Primary Immunodeficiencies Facing to Steroid Refractory (SR) Acute Intestinal Graft versus Host Disease (aGvHD)
Authors: Baskın Kubra , Haskologlu Sule , Islamoglu Candan , Ünal Emel , Dogu Figen , Ikinciogullari Aydan 
Published: October 2022

Background: The only curative therapy for many primary
immunodeficiencies is HSCT. aGvHD is a serious and potentially fatal
complication of HSCT with an incidence of nearly %50. Furthermore,
involvement of the lower gastrointestinal (LGI) tract is associated with
a poor prognosis. Unfortunately, there isn’t consensus about second-line
therapies for steroid-refractory (SR) aGvHD. Alpha 1 Antitrypsin (AAT)
is one of the second-line therapies. There isn’t a study in pediatric
population with acute SR-GvHD in the literature. Method: We
retrospectively evaluated data of 3 patients that received AAT as
second-line therapy for acute SR-GvHD. Results: Each patients’
response to treatment was unique. P1 had a complete response beginning
with the third dose of the treatment. P2 showed a partial response to
the treatment after the second dose. Despite 8 doses of the treatment,
P3 did not achieve remission. Conclusion: AAT may play a
promising role in the treatment of severe and refractory aGvHD in
children, without causing an additional immune suppression in opposite
to agents which were placed in guidelines. Further studies are warranted
with AAT for pediatric population.
Pharmacologic Treatment of Type 2 Diabetes in the United States, Sweden, and Israel
Authors: Lyu Beini , Sang Yingying , Selvin Elizabeth , Chang Alex R. , Alexander G Caleb , Melzer-Cohen Cheli , Coresh Josef , Shalev Varda , Chodick Gabriel , Karasik Avraham , Jesús Carrero Juan , Fu Edouard L , Xu Yang , E. Grams Morgan , Shin Jung-Im 
Published: October 2022

<p> </p>
Abstract
<p><strong>Objectives</strong> To characterize and compare glucose-lowering medication use in type 2 diabetes in the US, Sweden, and Israel, including adoption of newer medications and prescribing patterns.</p>
<p><strong>Research Design and Methods</strong> We used data from the National Health and Nutrition Examination Survey (NHANES) from the US, Stockholm CREAtinine Measurements project (SCREAM) from Sweden, and Maccabi Healthcare Services from Israel. Specific pharmacotherapy for type 2 diabetes between 2007 and 2018 were examined. </p>
<p><strong>Results </strong>Use of glucose-lowering medications among patients with type 2 diabetes was substantially lower in the US and SCREAM than in Maccabi (66.0% in NHANES, 68.4% in SCREAM, and 88.1% in Maccabi in 2017-2018). Among patients who took at least one glucose-lowering medication in 2017-2018, metformin use was also lower in the US and SCREAM (74.1% in NHANES, 75.9% in SCREAM, and 92.6% in Maccabi) whereas sulfonylureas use was greater in the US (31.5% in NHANES, 16.0% in SCREAM, and 14.9% in Maccabi). Adoption of DPP4i and SGLT2i were slower in the US and SCREAM than Maccabi. History of atherosclerotic cardiovascular disease, heart failure, reduced kidney function, and albuminuria were not consistently associated with greater use of SGLT2i or GLP1RA across the three countries. </p>
<p><strong>Conclusions </strong>There were substantial differences in real-world use of glucose-lowering medications across the US, Sweden, and Israel, with more optimal pharmacologic management in Israel. Variation in access to care and medication cost across countries may have contributed to these differences. SGLT2i and GLP1RA use in high-risk patients was limited in all three countries during this time period.</p>
Clinical Performance of Direct Posterior Composite Restorations in Patients with Amelogenesis Imperfecta
Authors: Tekçe N , Demirci M , Sancak EI , Güder G , Tuncer S , Baydemir C 
Published: October 2022

SUMMARY
The objective of this study was to analyze and assess the clinical performance of direct composite restorations using a nanohybrid and a nanofill composite material for posterior teeth in patients with amelogenesis imperfecta (AI). This study involved 15 patients between the ages of 14 and 30 years suffering from amelogenesis imperfecta (AI). During the study, the patients received direct composite restorations using either the Clearfil Majesty ES-2 (Kuraray Medical Inc, Tokyo, Japan) and Clearfil Universal Bond (Kuraray) or Filtek Ultimate Universal Restorative (3M ESPE, St Paul, MN, USA) and Single Bond Universal Adhesive (3M ESPE). The evaluations of the restorations were conducted per the modified USPHS criteria at the time of baseline as well as during the first-, second-, third-, and fourth-year follow-up sessions. After four years, it was observed that the cumulative success rate of direct posterior restorations was 98.1% for Clearfil Majesty ES-2 and 92.2% for Filtek Ultimate. During the study one Clearfil Majesty ES-2 restoration and four Filtek Ultimate restorations failed. There was a significant difference between Clearfil Majesty ES-2 and Filtek Ultimate in the color match in posterior restorations after three and four years. The causes of failure included marginal discoloration and caries, as well as fracture of the restoration. Hence, it can be stated that the use of nanohybrid or nanofill composites in posterior direct restorations in patients with AI looks promising. The failure rate of Clearfil Majesty ES-2 was found to be lower than that of Filtek Ultimate restorations. Clinically, the rate of optimum restorations conducted for partial discoloration, marginal adaptation, color match, and surface texture were observed to be higher when Clearfil Majesty ES-2 was used. However, additional studies are needed to assess the clinical performance of direct posterior composite materials in patients with AI.
Vertical Marginal Discrepancy Performance of a CAD-CAM System with Multiple Users
Authors: Pereira STPL , Roberts HW 
Published: October 2022

SUMMARYPurposeThe purpose of this evaluation was to evaluate the vertical marginal discrepancies of a computer-aided design-computer-aided manufacture (CAD-CAM) system used by different providers at separate time intervals.Methods and MaterialsLithium disilicate monolithic crowns on mandibular third molars were fabricated by three different providers inexperienced in digital dentistry. Using a precision rotary stage mounted on a digital recording microscope, the crown vertical marginal discrepancy was assessed using 160× magnification at 5-degree intervals around the crown marginal circumference for a total of 72 measurements per specimen. In addition to mean vertical marginal discrepancy, the maximum vertical marginal discrepancy, and its location as well as the percent of closed marginal assessments, were assessed. Mean data was analyzed using Kruskal–Wallis and Dunn post hoc testing at a 95% level of confidence (α=0.05).ResultsThe mean marginal vertical discrepancy for all specimens was 21.1 ± 5.5 μm and a significant difference (p=0.0016) existed between groups but with noted wide similarity overlap. No difference (p=0.65) was observed with the mean closed margin percentage, but a significant difference (p=0.0012) existed in the observed maximum marginal discrepancy between groups. The 2-mm axial wall height (AWH), 20-degree total occlusal convergence (TOC) had significantly less (p&lt;0.017) mean vertical marginal discrepancies than the 4-mm AWH, 20-degree TOC, and the 3-mm AWH, 16-degree TOC groups with the remaining groups similar (p&gt;0.147). The plotted location of the specimen’s maximum vertical discrepancy suggests a potential pattern amid the 360-degree margin circumference.ConclusionsUnder the conditions of this study, CAD-CAM-derived monolithic lithium disilicate ceramic crowns fabricated by different clinicians demonstrated mean vertical marginal discrepancy results that were less than the suggested maximum clinically acceptable values. A potential for patterns of marginal discrepancy results was identified and deserves further evaluation. Results should be interpreted with caution as in vitro methodologies vary and do not directly correlate with clinical conditions.
La enfermedad renal oculta en la población diabética de Copalillo, Guerrero, México
Authors: Cuevas Deloya Abrahan , Barlandas Rendón Nicolás Rogelio Eric , Hernández Nava Rocio Guadalupe , Ortiz Saldivar Emmanuel Antonio , Quintana Ponce Sandra 
Published: October 2022

Las enfermedades renales presentan una alta prevalencia entre la población mexicana. En el primer semestre del 2021, ocuparon el 10.o lugar como causa de muerte en México. La enfermedad renal crónica (ERC) se asocia con una disminución de la función renal relacionada con la edad, la presencia de hipertensión, diabetes, obesidad y trastornos renales primarios. Para esta investigación, durante el año 2018, se realizó un estudio descriptivo analítico en Copalillo, Guerrero, México, con el objetivo de identificar las alteraciones bioquímicas y antropométricas que influyen en la presentación y desarrollo de la enfermedad renal oculta (ERO) y la ERC en pacientes diabéticos. Se determinaron parámetros antropométricos y bioquímicos: creatinina, glucosa, urea, colesterol, triglicéridos, albuminuria y filtrado glomerular (FG). Para la determinación del FG, se empleó la ecuación denominada CKD-EPI, basada en la utilización de creatinina estandarizada, ajustada en función de la edad, sexo y raza. Para los parámetros cuantitativos se obtuvieron los valores estadísticos de: media, desviación estándar, valor máximo y valor mínimo; para la comparación de medias, se utilizó el valor p mediante la prueba t de Student usando el software Stata v14.2. La población total del estudio estuvo constituida por 86 pacientes adultos diabéticos y 114 no diabéticos, de los cuales 71 % (142) fueron del sexo femenino y 29 % (58) del masculino. Se identificó que 45 % de los pacientes diabéticos no seguían el tratamiento para esta patología, 87 % presentaron hiperglucemia y 7 % presentaron valores elevados de creatinina. La determinación del FG por medio de la ecuación de CKD-EPI permitió identificar a 11 pacientes con enfermedad renal, de los cuales cinco tenían ERO y seis ERC, esto es, 2.5 % y 3 % de la población total, respectivamente. Además, 81 % de estos pacientes con enfermedad renal eran diabéticos. Por último, se observaron diferencias estadísticamente significativas en los parámetros de creatinina, urea, albuminuria, filtrado glomerular, presión arterial diastólica, presión arterial sistólica y la edad entre los pacientes con enfermedad renal y aquellos sin la enfermedad.
Radiomic Study for Objectification of Diagnostics and Complex Treatment of Glioblastoma
Authors: Nikulshina Ya. O. , Redkin A. N. , Kolpakov A. V. , Zakharov M. A. 
Published: October 2022

Introduction.Glioblastoma is a neuroepithelial malignant brain tumour of predominantly astrocytic origin with an aggressive course and an extremely unfavorable prognosis. Since the median of overall survival with glioblastoma is 14.6 months after complex treatment that includes a combination of surgical treatment, radiation therapy and chemotherapy, the development a personalized approach in the diagnosis and treatment of glioblastomas is appeared to be urgent.Materials and methods. MRIs of a patient undergoing chemoradiotherapy for glioblastoma G4 were performed on the following MRI scanners: Philips Ingenia 1.5T and Philips Ingenia Ambient 1.5T. The analysis of MR-images was carried out using the Matlab 2021 apps.Results and discussion.MR-images were analyzed before and after surgery, and after a course of chemoradiotherapy. The statistical characteristics of the local brightness distribution of the lesion image, which are described by statistical texture parameters, were analyzed as informative features of the lesion area on the images. Initial confirmation of the ability to objectify diagnosis and treatment using the above statistical parameters of T2 MR images of lesion area has been obtained.Conclusion.The aim of further research in this area is to use radiomic study for planning and monitoring the treatment of high-grade gliomas, estimate disease outcomes, and analyze the response to complex treatments in a predictive way.
A Rare Case of Cholangiocellular Liver Cancer with Hematogenous Metastases and Organ Changes in the Generalization of the Process
Authors: Vorobeva O. V. 
Published: October 2022

Introduction. Cholangiocellular cancer is a malignant tumor from the epithelium of the bile ducts. Intravital diagnosis is often difficult to make due to the absence of any definitive signs of cancer and problems with detecting the first signs. Following the relevance of the problem, a case of cholangiocellular liver cancer with generalized metastases is presented.Materials and methods. The analysis of the received supporting medical documentation and the description of macroand micropreparations using histological (hematoxylin and eosin staining) and immunohistochemical methods were carried out.Results and discussion. Patient L.M., 60 years old, died at home, was referred by a general practitioner to the pathology department for autopsy examination. During the forensic autopsy, the macroscopic examination revealed dense liver substance, a «tree-like» mass of gray-yellow-brown color on the sections around the portal vein and intrahepatic bile ducts, with involvement of the right and left liver lobes and multiple gray nodules located throughout the liver parenchyma. The intrahepatic bile ducts malfunction due to expanding tumor tissue. Histological examination revealed a moderately differentiated tumor growth of cholangiocellular carcinoma, consisting of polymorphic cells separated by layers of fibrous tissue with areas of necrosis, foci of cholestasis. Immunohistochemical analysis of the tumor tissue of the lungs, liver: cytokeratins CAM 5.2 (+). All groups of lymph nodes of hepatoduodenal ligament, along vesicular and common bile ducts, hepatic artery and portal vein, surrounding left gastric and common hepatic artery, as well as lymph nodes of posterior pancreaticoduodenal group and distant lymph nodes are celiac; upper mesenteric and paraaortic zones appear unremarkable. Cerebral edema, pulmonary edema and necronephrosis were reported.Conclusion. The presented case is of particular interest to practitioners owing to the absence of the characteristic lymph node metastases and presence of hematogenous metastases and development of multiple organ failure.
Analysis of intercomponent relations in metageosystems by using simulation modeling
Authors: Yamashkin Stanislav Anatolyevich , Yamashkina Ekaterina Olegovna , Nikulin Vladimir Valerievich 
Published: October 2022

The article focuses on solving the scientific problem of quantitative analysis of intercomponent relationships in metageosystems of different hierarchical levels by using the method of simulation modeling. Studying the structure and properties of metageosystems proved to be based on the analysis of the regularities of interaction of the territorial components distributed in space. A list of requirements for the framework of simulation models of spatial processes is formulated, an algorithm for developing a model that describes the spatial-temporal processes occurring in territorial systems is presented. There have been singled out two directions for developing the framework of simulation modeling of spatial processes: deductive, in which the model building system must be initially designed in order to achieve the coverage
of solutions to the maximum number of tasks, and inductive, in which positive changes in the particular models turn into the basis for the development of the simulation framework. The combined use of deductive and inductive strategies will evolutionize the upgraded modeling framework and optimize the particular solutions developed on its basis. As an example of implementation of a software package that demonstrates the possibilities of simulation modeling for solving the problem of analyzing intercomponent relations in metageosystems there has been developed an information system for modeling traffic flows in urban metageosystems. The developed system consists of the following modules: a map editor, a component for working with a database, a subsystem for visualizing interactive graphical web interfaces, an auxiliary module for performing the necessary mathematical calculations, a subsystem for modeling urban traffic, and a recommender subsystem for generating recommendations based on rules. The implemented software package for simulating traffic flows in urban metageosystems can be used to create dynamic transport models able to predict the flow depending on the situation. The model serves as a tool for making strategic decisions regarding the development of the spatial struc-ture of a city or region. The system modules aggregate interacting with each other and ensure the reliable and uninterrupted operation of the simulation system as a whole.
DESKRIPSI KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS DITINJAU DARI SELF-REGULATED LEARNING
Authors: Pasha Veda Fitaloka , Aini Indrie Noor 
Published: October 2022

Penelitian ini bertujuan untuk menganalisis kemampuan pemahaman konsep matematis pada materi bentuk aljabar ditinjau dari self-regulated learning. Subjek dalam penelitian deskriptif kualitatif ini berjumlah 4 orang siswa SMP kelas VII di daerah Telagasari Karawang Jawa barat yang dipilih secara purposive sampling. Instrumen utama ialah peneliti sendiri, sedangkan instrumen pendukung yang dipakai dalam penelitian ini adalah soal uraian yang berjumlah tiga soal. Analisis data yang digunakan dalam penelitian ini adalah analisis jawaban siswa yang merujuk pada ketujuh indikator kemampuan pemahaman konsep matematis serta melaksanakan wawancara tak terstruktur. Hasil penelitian ini memperlihatkan bahwasanya siswa 1 dan 2 hanya mampu memenuhi tiga indikator yakni menyatakan ulang sebuah konsep, menyajikan konsep dalam berbagai untuk representasi matematis dan menggunakan, memanfaatkan, juga memilihkan prosedur ataupun operasi tertentu juga mengaplikasikan konsep ataupun algoritma pemecahan masalah sementara siswa 3 dan 4 hanya mampu memenuhi satu indikator yakni menyebutkan ulang sebuah konsep. Sehingga dapat disimpulkan bahwa kemampuan pemahaman konsep matematis bentuk aljabar ditinjau dari self-regulated learning tergolong rendah. Hal itu dapat diperkuat dengan hasil wawancara pada siswa yang memperlihatkan bahwasanya ketiga siswa mempunyai kemampuan self-regulated learning yang rendah.
Cardiac troponins as biomarkers of cardiomyocyte damage in arterial hypertension: emphasis on pathophysiological mechanisms
Authors: Чаулин А.М. 
Published: October 2022

Введение. Многие патологические состояния различного генеза вызывают повреждение кардиомиоцитов (КМЦ). Одним из наиболее чувствительных и специфичных критериев оценки степени повреждения КМЦ являются сердечные тропонины (СТ) - регуляторные белковые молекулы, которые высвобождаются в сыворотку крови из КМЦ при их гибели или повреждении. Новые высокочувствительные методы детекции СТ позволяют выявлять незначительные повреждения КМЦ на самых ранних стадиях сердечно-сосудистых патологий, в связи с чем могут изменить представление о патогенезе и открыть новые диагностические возможности. Цель обзора - обобщение патофизиологических механизмов, лежащих в основе повреждения КМЦ и высвобождения СТ в сосудистое русло при артериальной гипертензии и обсуждение клинического значения изменения уровня СТ у пациентов, страдающих артериальной гипертензией. Методика. При подготовке обзора были использованы отечественные (elibrary/РИНЦ) и зарубежные (Embase, Pubmed/Medline) базы данных. Заключение. В повреждении КМЦ и высвобождении СТ при артериальной гипертензии задействованы следующие патофизиологические механизмы: гипертрофия миокарда, апоптоз КМЦ, повреждение клеточной мембраны КМЦ и повышение ее проницаемости для молекул СТ, а также изменение скорости клубочковой фильтрации в почках. С учетом данных о прогностической ценности уровня СТ при артериальной гипертензии открываются перспективы для использования этих биомаркеров при выборе тактики ведения пациентов.
Introduction. Many pathological conditions, both of cardiovascular and extra-cardiac genesis, cause damage to cardiomyocytes (CMC). One of the most sensitive and specific criteria for the detection of CMC damage are cardiac troponins (CT), regulatory protein molecules that are released into the blood from CMC when these cells are killed or damaged. New, highly sensitive methods for detecting CT can identify minor damage to CMC at the earliest stages of cardiovascular pathologies. Thus, these methods may change the understanding of the pathogenesis and suggest new diagnostic possibilities. The aim of this review was to summarize the pathophysiological mechanisms underlying the damage to CMC with the release of CT and to discuss the clinical significance of elevated CT in arterial hypertension. Methods. In the search for literature, Russian (elibrary/RSCI) and international (Embase, Pubmed/Medline) databases were used. The following keywords were used: myocardial damage, cardiac troponins, arterial hypertension, pathophysiology. Conclusion. The CMC damage and the CT release in arterial hypertension are mediated by the following pathophysiological mechanisms: myocardial hypertrophy, CMC apoptosis, damage to the CMC cell membrane and its increased permeability to CT molecules, and changes in the glomerular filtration rate. Taking into account the prognostic value of CT in arterial hypertension, there are prospects for using these biomarkers in choosing tactics for management of patients.