bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of recreational and tourist attractiveness of roadside territories
Authors: Anisimova Svitlanа 
Published: September 2022

Problem. Currently, many roads and their infrastructure have been severely damaged by hostilities. In the post-war development of Ukraine, especially transport infrastructure, much attention should be paid to the restoration and construction of recreational facilities in roadside areas to ensure short-term and long-term recreation of drivers and passengers. Not many studies have been devoted to the problems of providing tourist and recreational potential with transport and recreational infrastructure in Ukraine. Basically, researchers pay attention to the characteristics of the transport complex of Ukraine in terms of the development of the roads themselves. Thus, it is necessary to determine the principles of selection of territories for the development of recreational facilities along highways in the restoration and development of post-war Ukraine. Goal. The aim of the work is to develop criteria and principles for assessing roadside areas in terms of the need and possibility of locating tourist and recreational infrastructure. Methodology. Analytical research methods were used to determine the approaches of foreign countries to the location of tourist and recreational facilities on highways. Determining the most attractive roadside areas for tourist and recreational infrastructure is based on the developed criteria and methodological approach to scoring the requirements of vacationers. Results. The main highways, which are tourist and recreational routes for Ukrainian and foreign vacationers, are characterized. The tourist and recreational infrastructure and its influence on the development of recreational business in the state are determined. The principles of location of recreational facilities in roadside areas abroad are analyzed. Recreational requirements of traveling tourists are revealed. Criteria and principles for assessing roadside areas for the construction of recreational facilities have been developed. Originality. Criteria and methodological approach for assessing the most attractive roadside areas for tourist and recreational infrastructure have been developed. The main priorities are suggested that should be the basis of tourism and recreation policy of the state in the post-war reconstruction of Ukraine. Practical value. The use of the proposed methodological approach to determining the most attractive areas for the construction of tourist and recreational infrastructure will help avoid chaotic construction of roadside space and unmotivated alienation of agricultural land.
Use of heparin to rescue immunosuppressive monocyte reprogramming by glioblastoma-derived extracellular vesicles
Authors: Himes Benjamin T. , Fain Cori E. , Tritz Zachariah P. , Nesvick Cody L. , Jin-Lee Helen J. , Geiger Philipp A. , Peterson Timothy E. , Jung Mi-Yeon , Parney Ian F. 
Published: September 2022

OBJECTIVE
The profound immunosuppression found in glioblastoma (GBM) patients is a critical barrier to effective immunotherapy. Multiple mechanisms of tumor-mediated immune suppression exist, and the induction of immunosuppressive monocytes such as myeloid-derived suppressor cells (MDSCs) is increasingly appreciated as a key part of this pathology. GBM-derived extracellular vesicles (EVs) can induce the formation of MDSCs. The authors sought to identify the molecular consequences of these interactions in myeloid cells in order to identify potential targets that could pharmacologically disrupt GBM EV–monocyte interaction as a means to ameliorate tumor-mediated immune suppression. Heparin-sulfate proteoglycans (HSPGs) are a general mechanism by which EVs come into association with their target cells, and soluble heparin has been shown to interfere with EV-HSPG interactions. The authors sought to assess the efficacy of heparin treatment for mitigating the effects of GBM EVs on the formation of MDSCs.

METHODS
GBM EVs were collected from patient-derived cell line cultures via staged ultracentrifugation and cocultured with monocytes collected from apheresis cones from healthy blood donors. RNA was isolated from EV-conditioned and unconditioned monocytes after 72 hours of coculture, and RNA-sequencing analysis performed. For the heparin treatment studies, soluble heparin was added at the time of EV-monocyte coculture and flow cytometry analysis was performed 72 hours later. After the initial EV-monocyte coculture period, donor-matched T-cell coculture studies were performed by adding fluorescently labeled and stimulated T cells for 5 days of coculture.

RESULTS
Transcriptomic analysis of GBM EV–treated monocytes demonstrated downregulation of several important immunological and metabolic pathways, with upregulation of the pathways associated with synthesis of cholesterol and HSPG. Heparin treatment inhibited association between GBM EVs and monocytes in a dose-dependent fashion, which resulted in a concomitant reduction in MDSC formation (p < 0.01). The authors further demonstrated that reduced MDSC formation resulted in a partial rescue of immune suppression, as measured by effects on activated donor-matched T cells (p < 0.05).

CONCLUSIONS
The authors demonstrated that GBM EVs induce broad but reproducible reprogramming in monocytes, with enrichment of pathways that may portend an immunosuppressive phenotype. The authors further demonstrated that GBM EV–monocyte interactions are potentially druggable targets for overcoming tumor-mediated immune suppression, with heparin inhibition of EV-monocyte interactions demonstrating proof of principle.
Growth risk classification and typical growth speed of convexity, parasagittal, and falx meningiomas: a retrospective cohort study
Authors: Yamada Shuhei , Hirayama Ryuichi , Iwata Takamitsu , Kuroda Hideki , Nakagawa Tomoyoshi , Takenaka Tomofumi , Kijima Noriyuki , Okita Yoshiko , Kagawa Naoki , Kishima Haruhiko 
Published: September 2022

OBJECTIVE
Meningiomas are the most common primary intracranial tumors, and their clinical and biological characteristics vary by location. Convexity, parasagittal, and falx meningiomas account for approximately 50%–65% of intracranial meningiomas. Focusing only on these locations, the aim of this study was to determine the typical speed of tumor growth, to assess the growth risk, and to show the possible tumor volume that many lesions can reach after 5 years.

METHODS
Patients with radiologically suspected convexity, parasagittal, or falx meningiomas at the authors’ institution were studied retrospectively. The relative growth rate (RGR) and annual volume change (AVC) were calculated from MRI at more than 3-month intervals. Based on sex, age, and signal intensity on T2-weighted MRI, the cases were classified into three groups: extremely high-growth, high-growth, and low-growth groups.

RESULTS
The data of 313 cases were analyzed. The median RGR and AVC for this entire cohort were 6.1% (interquartile range [IQR] 2.4%–16.0%) and 0.20 (IQR 0.04–1.18) cm3/year, respectively. There were significant differences in sex (p = 0.018) and T2-weighted MRI signal intensity (p < 0.001) for RGR, and T2-weighted MRI signal intensity (p < 0.001), tumor location (p = 0.025), and initial tumor volume (p < 0.001) for AVC. The median RGR and AVC were 17.5% (IQR 8.3%–44.1%) and 1.05 (IQR 0.18–3.53) cm3/year, 8.2% (IQR 2.9%–18.6%) and 0.33 (IQR 0.06–1.66) cm3/year, and 3.4% (IQR 1.2%–5.8%) and 0.04 (IQR 0.02–0.21) cm3/year for the extremely high-growth, high-growth, and low-growth groups, respectively, with a significant difference among the groups (p < 0.001). A 2.24-times, or 5.24 cm3, increase in tumor volume over 5 years was typical in the extremely high-growth group, whereas the low-growth group showed little change in tumor volume even over a 5-year follow-up period.

CONCLUSIONS
For the first time, the typical speed of tumor growth was calculated, focusing only on patients with convexity, parasagittal, and falx meningiomas. In addition, the possible tumor volume that many lesions in these locations can reach after 5 years was shown based on objective indicators. These results may allow clinicians to easily detect lesions that require frequent follow-up or early treatment by determining whether they deviate from the typical range of the growth rate, similar to a growth chart for children.
Radiological and clinical outcomes of concurrent hamstring stretching with quadriceps strengthening in patients with knee osteoarthritis: A randomized clinical trial
Authors: Mahmoud Waleed S. , Osailan Ahmad , Elnaggar Ragab K. , Alhailiy Ali B. 
Published: September 2022

BACKGROUND: Hamstring shortening altered joint reaction forces during activities of daily living (ADL), causing knee pain. Moreover, weak quadriceps may negatively distribute the compressive and shear forces at the knee joint. PURPOSE: The study examined the effect of adding hamstring stretching to quadriceps strengthening exercises on joint space narrowing (JSN), medial joint space width (mJSW), and physical abilities in patients with knee osteoarthritis (KOA). METHODS: A total of 42 osteoarthritis patients, aged from 50 to 65 years, were randomized and assigned into 2 groups: the study and the control groups. Quadriceps strengthening exercises were given to both groups, while static hamstring stretching was applied to only the study group. Patients of both groups were screened with a weight-bearing x-ray beam to investigate the JSN, mJSW, and functional abilities measured in the WOMAC scale. The Outcomes were evaluated at the baseline and immediately after 6 weeks of treatment. RESULTS: The mJSW improved in the study group ([Formula: see text] 0.001) compared to the control group ([Formula: see text] 0.07). The OARSI JSN was enhanced significantly in both groups, but in favor of the study group ([Formula: see text] 0.001) over the control group ([Formula: see text] 0.046). Both MVIC and total score of WOMAC were significantly improved in both groups ([Formula: see text] 0.001). CONCLUSION: Adding static hamstring stretching to quadriceps strengthening exercises provided a substantial effect on mJSW, JSN, and functional abilities in KOA patients.
Effects of trunk stabilization exercises using laser pointer visual feedback in patients with chronic stroke: A randomized controlled study
Authors: Kim Kyoung-Il , Im Sang-Cheol , Kim Kyoung 
Published: September 2022

BACKGROUND: Many previous studies have cited the importance of trunk stabilization exercises in patients with stroke. However, the evidence for optimal trunk stabilization exercises for patients with stroke is still lacking. OBJECTIVE: To investigate the effects of laser pointer visual feedback in trunk stabilization exercises that are important for improving trunk dysfunction in patients with stroke. METHODS: In total, 30 patients with chronic stroke were randomly assigned to experimental and control groups. The experimental group underwent a traditional stroke rehabilitation program and trunk stabilization exercises using laser pointer visual feedback. The control group underwent a traditional stroke rehabilitation program and trunk stabilization exercises without visual feedback. Pre- and postintervention results after 6 weeks were evaluated using the Berg Balance Scale, static and dynamic plantar pressure, 10-m walk test, and the Korean version of the Fall Efficacy Scale. The results were analyzed using a general linear repeated measurement model. RESULTS: Both groups showed significant improvements in BBS scores, static plantar pressure, dynamic plantar pressure, 10 MWT, and K-FES scores after 6 weeks of intervention (P< 0.05). Compared to the control group, significant improvements were observed in the experimental group in the Berg Balance Scale scores, dynamic paretic posterior plantar pressure, 10-m walk test, and Korean version of the Fall Efficacy Scale scores (P< 0.025). CONCLUSION: Our results demonstrated the effectiveness of visual feedback during trunk stabilization exercises for resolving trunk dysfunction in patients with stroke. Trunk stabilization exercises using laser pointer visual feedback have been found to be more effective in balance, walking, and fall efficacy in patients with stroke.
RAS mutations that have a major impact on current cancer genomic medicine
Authors: Hayashi Takuma , Yaegashi Nobuo , Konishi Ikuo 
Published: September 2022

The status of rat sarcoma viral oncogene homolog (RAS) proteins is a negative predictive biomarker for anti-epidermal growth factor receptor (EGFR) therapy in metastatic colon cancer. In the phase 2 CHRONOS trial, patients with mutant gene(s) are ineligible for anti-EGFR therapy. However, our studies revealed that splicing caused by the RAS mutations, which were considered oncogenic, generates unfunctional RAS family. Especially, Kirsten Rat Sarcoma (KRAS) silent variants are of concern to be a serious problem in genomic cancer medicine.
School of Ball Choreography by KNUKiM in Modern Scientific Discourse
Authors: Korytna Alina 
Published: September 2022

The purpose of the article is to identify the main approaches to understanding the activities of the school of ballroom choreography of the Kyiv National University of Culture and Arts (KNUKiM) in modern research. Research methodology. Methods of analysis and synthesis are applied; historical for consideration of scientific publications in chronological order; method of theoretical generalization for formulating conclusions, etc. Scientific novelty. The scientific novelty is to identify the degree of research of the phenomenon of "school of ballroom choreography KNUKiM" and the main approaches to understanding its activities. Conclusions. The analysis of the scientific discourse on the school of ballroom choreography of KNUKiM proved the importance not only of narrow choreographic optics but also the legitimacy of the application of culturological approaches, given the scale of the phenomenon of this school. In fact, only T. Pavliuk and A. Pidlypska consider the "school of ballroom choreography of KNUKiM", and not some aspects of its activities, without calling the phenomenon "school". Most of the authors, resorting to demonstrating the importance of scientific and methodological achievements of ballroom dance teachers KNUKiM, as well as graduates of the Department of Ballroom Choreography, prove the legitimacy of the definition of "scientific and pedagogical school". Despite numerous mentions of the Department of Ballroom Choreography KNUKiM and its representatives, it should be noted that researchers have not paid due attention to the preconditions and characteristics of the formation of art and pedagogical school of ballroom choreography KNUKiM, clarifying the main directions of the Department of Ballroom Choreography its role in the cultural and artistic life of Ukraine, the identification of the personal contribution of school representatives, the development of periodization of school activities, etc. The relevance of such a study is undeniable, and its results can be used in further theoretical developments on the activities of art, pedagogical, scientific schools in the process of cultural creation, choreographic art in Ukraine, etc.
Key words: Department of Ballroom Choreography KNUKiM, Ukrainian culture, art school, scientific discourse.
Pavlo Virsky's creativity is the symbiosis of choreographic and theatre art of the XX century
Authors: Roy Euvgenii , Roy Vyacheslav 
Published: September 2022

Purpose of Research. The purposes of the research are to analyse the artistic works of Pavlo Virsky, the Ukrainian choreographer-director, in the State Honored Academic Dance Ensemble of Ukraine and to reveal the phenomenon of his theatrical folk choreography in the context of theatrical art. Methodology. The scientific methodological basis of the research is the combination of the dialectical principle of knowledge, systemic, socio-cultural and historical approaches, the fundamental provisions of the culture theory and history of. The general scientific and interdisciplinary research methods were used, which revealed the close connection between folk and stage dance and theatre art in the artist's staging work. Scientific Novelty. The scientific novelty of the results are to identify and generalise the features of dance art of Ukrainian choreographer, which brought his theatrical performances in the ensemble to a kind of author's folk dance theatre. Conclusions. P. Virsky’s creativity is a living proof of the syncretic connection among dance, stage and theatrical art. These spheres merged so strongly and organically in his many years of work in one of the best dance groups in Ukraine, because everything he did in the national folk choreography had a pronounced theatrical and figurative character. Having absorbed modern ideas and forms of choreography, reworking them into his plot productions, the artist forms clear guidelines for the synthesis of folk – choreographic and theatrical arts. Thus, he allegedly points to a promising direction in the development of folk dance art in Ukraine. In addition, as a result of the analysis of artistic and stylistic features of P. Virsky's artistic works we have found out that he managed to expand the genre boundaries of folk-stage dance art, bringing them closer to the style of performance. This allows us to talk about a kind of author's folk dance theatre, the basic basis of which was the State Honored Academic Dance Ensemble of Ukraine.
Keywords: theatrical folklore, syncretism of folk-stage choreography, symbiosis of stage arts, folk dance theater, artistic-stage imagery.
PASTORALISTS’ KNOWLEDGE ON PREVALENT CATTLE DISEASES AND PARASITES MANAGEMENT PRACTICES IN NORTH-EAST, NIGERIA.
Authors: Bashir Mohammed Bawuro  , Ndaghu Augustine Anthony  , Anonguku Iorfa  
Published: September 2022

In as much as there exist supportive vegetation and good management practices of cattle diseases and parasites, Cattle rearing can be proud not only in North east but throughout Nigeria. The study assessed pastoralists’ knowledge on prevalent cattle diseases and parasites management in North East, Nigeria. Specifically, the study identified the prevalent cattle diseases and parasites in the study area, identified pastoralists awareness of cattle diseases and parasites, assessed pastoralists knowledge of cattle diseases and parasites. Multi Stage sampling techniques were used to select four hundred and twenty pastoralists for the study. The pastoralists comprised 126, 105, 84 and 105 from Adamawa, Bauchi, Gombe and Taraba. Descriptive statistics and logit regression were used to analyse the data. Result revealed that contagious bovine Pleuropneumonia (97.8%) and Tsetse flies (99.3%) were the most prevalent cattle diseases and parasites. Contagious bovine Pleuropneumonia and Tape worms ranked 1st with a mean score of 2.81 and 2.77 were highly prevalent. Majority (97.8% and 99.0%) of the pastoralists were aware of bovine tuberculosis and Liver flukes. The result also showed that the pastoralists had a high knowledge of Contagious Bovine Pleuropneumonia and Tape worms with a mean score of 1.89 and 1.86. Result of logit regression analysis revealed Blackleg (0.0092), Foot and Mouth Diseases (0.0317), Tick (0.0053), Tsetse flies (0.0002), Tapeworm (0.0655), were found to be positive and statistically significant at 5%. It is therefore recommended that extension services should target more pastoralists so as to aid their knowledge on the modern practices of cattle diseases and parasites management practices.
COMPUTATIONAL ANALYSIS OF FUNCTIONAL EFFECTS OF SINGLE NUCLEOTIDE POLYMORPHISM ON OVINE INTERFERON TAU
Authors: MUSA S.I , YAHAYA K.O , YAHAYA A 
Published: September 2022

The objective of this study was to evaluate the functional effects of Single Nucleotide Polymorphism(SNP) in ovine interferon tau using computational methods. Data on ovine interferon was retrieved from data base of National Center for Biotechnology Information ((GenBank). Functional effects of substitution of Leucin by Proline at position 26 of interferon protein chain was predicted using Protein Variation Effect Analyser, Panther server and Poly phen 2 (Polymorphism phenotyping). Provean score of - 5.828 was obtained, indicating a deleterious effect of the amino acid substitution. Panther server indicated damaging effect of the SNP with Pdel ( probability of deleterious effect) of 0.5. Similarly, Poly phen 2 showed damaging effect of the amino acid substitution. It can be concluded that substitution of Leucin by proline at position 26 of the protein sequence of interferon tau resulted in deleterious effect on the functionality of ovine interferon tau. Studies in Single Nucleotide Polymorphism on ovine interferon tau can provide better understanding of biomarkers associated with efficiency of maternal pregnancy recognition in the ovine species.
Sistem Pendukung Keputusan Pemilihan Ketua Osis dengan Metode Simple Additive Weighting SMK Negeri 11 Pandeglang
Authors: Mardiana Riki , Destaryana Aldi , Henderi Henderi 
Published: September 2022

Sistem pendukung keputusan pemilihan ketua osis ialah aplikasi yang di dalamnya ada proses pemilihan siswa yang bisa jadi calon ketua osis. Sistem ini diperlukan karena proses yang ada, tidak mendapatkan siswa yang sesungguhnya berkompeten untuk menjadi ketua OSIS. Tujuan dari riset ini merupakan mencari calon ketua osis dengan sistem pendukung keputusan yang bisa memperhitungkan calon ketua osis yang terdapat di Sekolah Menengah Kejuruan (SMK) Negara 11 Pandeglang. Tata cara yang digunakan dalam riset ini adalah metode pengumpulan informasi yang digunakan ialah memastikan kriteria, variable kriteria, melaksanakan perhitungan. Ada pula hasil proses SAW ini berbentuk peringkat, hasil proses ini direkomendasikan selaku ketua OSIS bersumber pada kriterianya.
Kata Kunci – Sistem Informasi, Ketua Osis, Metode SAW.
Essay of Different Proportion of Protein on Growth of juvenile Distichodus antonii schilthius 1891.l. In vivo in Kisangani (D. R. Congo.)
Authors: Serge Munganga Kabate , Osombause Sango Joël  , Kalala Gaëtan  , Ngalya Benga Nathalie  , Monsengo Mbabruki Franco  , Ebwa Joël  , Serkali Maliba  
Published: September 2022

The present work was carried out in 201 at Facultural Institute of Agronomic Science of Yangambi in the province of Tshopo (RDC) and focuses on the Essay of different proportion of protein on growth of juvenile Distichodus antonii schilthius 1891.l. In vivo in Kisangani (D. R. Congo.) The objective pursued by this work was of study the performance of growth of juvenile of Distichodus antonii schilthius vivo in. Methodology and results: It resulted from the study that Distichodus antonii has doubled weight during all the experience. According to the t test of STUDENT calculated between the gain of body mass of fish fed with the food R1 continent 300% of protein and the R2 continent 25 % of protein showed a non significant difference (P<0,05). The SGR (Specific Growth Rate ‘‘SGR’’) appeared meaningfully and significantly correlated to the fed. The results of mortality rate during this experience did not seem being correlated to the different diet but rather to the manipulation of fish and other experimental protocols artefacts. The protein content of the carcasses of Distichodus varied of 117, 40% for the food R1 and 135, 84% for the food R2. The diet R2 appeared performing compared to the diet R1 according to body protein gain by unit of consumed protein and for the weight gain by unit of consumed protein by Distichodus antonii.