bluuebunny/crossref_metadata_2025_split huggingface dataset:
Provider reported challenges with completing death certificates: A focus group study demonstrating potential sources of error
Authors: Morgan Allie , Andrew Thomas , Guerra Sylvia M. A. , Luna Valeria , Davies Louise , Rees Judy R. 
Published: May 2022

Objectives
To characterize the experiences of providers in completing the cause of death section on death certificates, with particular reference to deaths in people who have cancer.

Methods
Focus groups were conducted until thematic saturation was reached, resulting in four groups over three months. Participants were from a variety of specialties and levels and types of training. Focus groups were recorded and transcribed verbatim and analyzed using constant comparison analysis.

Results
Three types of challenges to case classification were identified. 1) Infrastructural and procedural challenges encountered when completing death certificates, including the rigid structure of the form, lack of training in its completion, and lack of real-time feedback. 2) Clinical uncertainty and the varied approaches providers take to determine the cause of death based on their perception of the purpose of the death certificate. 3) Choosing cause of death in decedents with a history of cancer.

Conclusions
There are specific and substantial challenges in the death certification process that lead to errors in documenting the cause of death, but many of these challenges could be addressed with structural change to the forms or mechanism of training. Using these data to inform change could improve the death certification process and reliability of this data.
Diagnostic value of smartphone in obstructive sleep apnea syndrome: A systematic review and meta-analysis
Authors: Kim Do Hyun , Kim Sung Won , Hwang Se Hwan 
Published: May 2022

Objectives
To assess the diagnostic utility of smartphone-based measurement in detecting moderate to severe obstructive sleep apnea syndrome (OSAS).

Methods
Six databases were thoroughly reviewed. Random-effect models were used to estimate the summary sensitivity, specificity, negative predictive value, positive predictive value, diagnostic odds ratio, summary receiver operating characteristic curve and measured the areas under the curve. To assess the accuracy and precision, pooled mean difference and standard deviation of apnea hypopnea index (AHI) between smartphone and polysomnography (95% limits of agreement) across studies were calculated using the random-effects model. Study methodological quality was evaluated using the QUADAS-2 tool.

Results
Eleven studies were analyzed. The smartphone diagnostic odds ratio for moderate-to-severe OSAS (apnea/hypopnea index > 15) was 57.3873 (95% confidence interval [CI]: [34.7462; 94.7815]). The area under the summary receiver operating characteristic curve was 0.917. The sensitivity, specificity, negative predictive value, and positive predictive value were 0.9064 [0.8789; 0.9282], 0.8801 [0.8227; 0.9207], 0.9049 [0.8556; 0.9386], and 0.8844 [0.8234; 0.9263], respectively. We performed subgroup analysis based on the various OSAS detection methods (motion, sound, oximetry, and combinations thereof). Although the diagnostic odds ratios, specificities, and negative predictive values varied significantly (all p < 0.05), all methods afforded good sensitivity (> 80%). The sensitivities and positive predictive values were similar for the various methods (both p > 0.05). The mean difference with standard deviation in the AHI between smartphone and polysomnography was -0.6845 ± 1.611 events/h [-3.8426; 2.4735].

Conclusions
Smartphone could be used to screen the moderate-to-severe OSAS. The mean difference between smartphones and polysomnography AHI measurements was small, though limits of agreement was wide. Therefore, clinicians should be cautious when making clinical decisions based on these devices.
Do patients’ pre-treatment expectations about acupuncture effectiveness predict treatment outcome in patients with chronic low back pain? A secondary analysis of data from a randomised controlled clinical trial
Authors: Zieger Anja , Kern Alexandra , Barth Jürgen , Witt Claudia M. 
Published: May 2022

Objective
This secondary analysis of a randomised controlled patient-blinded trial comparing effectiveness and side effect briefings in patients with chronic low back pain (CLBP) investigated the association between patients’ pre-treatment expectations about minimal acupuncture treatment and pain intensity as outcome during and after the end of the treatment.

Methods
Chronic low back pain patients with a pain intensity of at least 4 on a numeric rating scale from 0 to 10 received eight sessions of minimal acupuncture treatment over 4 weeks. The primary outcome was change in pain intensity rated on a Numerical Rating Scale (NRS 0–10) from inclusion visit to treatment session 4 and to the end of the treatment. Patients’ expectations about the effectiveness of acupuncture were assessed using the Expectation for Treatment Scale (ETS) before randomization. Linear regression was applied to investigate whether patients’ pre-treatment expectations predicted changes in pain intensity during and after treatment.

Results
A total of 142 CLBP patients (40.1 ± 12.5 years; 65.5% female) were included in our analysis. Patients’ pre-treatment expectations about acupuncture treatment were associated with changes in pain intensity after four sessions of minimal acupuncture treatment (b = -0.264, p = 0.002), but not after the end of the treatment. This association was found in females and males.

Conclusions
Our results imply that higher pre-treatment expectations only lead to larger reductions in pain intensity in the initial phase of a treatment, with a similar magnitude for both females and males. As the treatment progresses in the second half of the treatment, adapted expectations or other non-specific effects might play a more important role in predicting treatment outcome.
The health impacts of the COVID-19 pandemic on adults who experience imprisonment globally: A mixed methods systematic review
Authors: Kim Hannah , Hughes Emily , Cavanagh Alice , Norris Emily , Gao Angela , Bondy Susan J. , McLeod Katherine E. , Kanagalingam Tharsan , Kouyoumdjian Fiona G. 
Published: May 2022

Background
The prison setting and health status of people who experience imprisonment increase the risks of COVID-19 infection and sequelae, and other health impacts of the COVID-19 pandemic.

Objectives
To conduct a mixed methods systematic review on the impacts of the COVID-19 pandemic on the health of people who experience imprisonment.

Data sources
We searched Medline, PsycINFO, Embase, the Cochrane Library, Social Sciences Abstracts, CINAHL, Applied Social Sciences Index and Abstracts, Sociological Abstracts, Sociology Database, Coronavirus Research Database, ERIC, Proquest Dissertations and Theses, Web of Science, and Scopus in October 2021. We reviewed reference lists for included studies.

Study eligibility criteria
Original research conducted in or after December 2019 on health impacts of the COVID-19 pandemic on adults in prisons or within three months of release.

Study appraisal and synthesis methods
We used the Joanna Briggs Institute’s Critical Appraisal Checklist for Qualitative Research for qualitative studies and the Joanna Briggs Institute’s Critical Appraisal Checklist for Studies Reporting Prevalence Data for quantitative studies. We qualitized quantitative data and extracted qualitative data, coded data, and collated similar data into categories.

Results
We identified 62 studies. People in prisons had disproportionately high rates of COVID-19 infection and COVID-19 mortality. During the pandemic, all-cause mortality worsened, access to health care and other services worsened, and there were major impacts on mental wellbeing and on relationships with family and staff. There was limited evidence regarding key primary and secondary prevention strategies.

Limitations
Our search was limited to databases. As the COVID-19 pandemic is ongoing, more evidence will emerge.

Conclusions
Prisons and people who experience imprisonment should be prioritized for COVID-19 response and recovery efforts, and an explicit focus on prisons is needed for ongoing public health work including emergency preparedness.

Prospero registration number
239324.
Mechanical and chemical bond for composite action of precast beams
Authors: Yousef Rana F. , Al-Rubaye Muna M. , Muteb Haitham H. 
Published: May 2022

AbstractFor utility of economical and practical construction, precast concrete is used due to its advantages such as reliability, durability, and higher quality. The appropriate selection of connection between the precast elements can have a significant influence on both the structural performance and long-term durability of such precast system. In this study, the effects of different connecting techniques on the performance of the precast composite flanged beams were experimentally and numerically investigated. The experimental program included testing up to failure under flexural loading conditions three groups of composite specimens: reference group, mechanical connecting group and chemical connecting group. The numerical assessment was done by using a finite element analysis to get a better insight and analyze the response of tested composite beams that available in the software package ABAQUS. The experimental results showed the advantageous effects of using mechanical connecting technique, as evident from improvement of the ultimate capacity or ductility of the precast composite beams. The results also showed that the predicted structural behavior using finite element analysis in terms of ultimate carrying loads, load-midspan deflection curves and crack patterns of the composite beams was in good agreement with the experimental data.
Disentangling the impact of mean reversion in estimating policy response with dynamic panels
Authors: Besstremyannaya Galina , Golovan Sergei 
Published: May 2022

Abstract
This article accounts for multivariate dependence of the variable of policy interest in dynamic panel data models by disentangling the two sources of intertemporal dependence: one from the effect of the policy variable and the other from mean reversion. In a situation where intensity of the policy varies over time, we estimate the unconditional mean in the autoregressive process as a function of the agent’s characteristics and the policy intensity. Comparison of the fitted values of the unconditional mean under different values of the policy intensity enables identification of the policy effect cleared of mean reversion. The approach is relevant for measuring the effect of reforms, which use an intertemporal incentive where intensity of the reform varies over time. The empirical part of the article assesses the effect of hospital financing reform based on incentive contracts, related to the observed quality of services at Medicare hospitals in 2013–2019. We find a direct association between prior quality and quality improvement owing to the reform. Our result reassesses a stylized fact in the literature, which asserts that a pay-for-performance incentive leads to greater improvements at hospitals with lower baseline quality.
Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021)
Authors: Perrin Charles L. , Agranat Israel , Bagno Alessandro , Braslavsky Silvia E. , Fernandes Pedro Alexandrino , Gal Jean-François , Lloyd-Jones Guy C. , Mayr Herbert , Murdoch Joseph R. , Nudelman Norma Sbarbati , Radom Leo , Rappoport Zvi , Ruasse Marie-Françoise , Siehl Hans-Ullrich , Takeuchi Yoshito , Tidwell Thomas T. , Uggerud Einar , Williams Ian H. 
Published: May 2022

Abstract
This Glossary contains definitions, explanatory notes, and sources for terms used in physical organic chemistry. Its aim is to provide guidance on the terminology of physical organic chemistry, with a view to achieving a consensus on the meaning and applicability of useful terms and the abandonment of unsatisfactory ones. Owing to the substantial progress in the field, this 2021 revision of the Glossary is much expanded relative to the previous edition, and it includes terms from cognate fields.
Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery
Authors: Recep Eymen , Bayoglu Burcu , Arslan Caner , Goksedef Deniz , Ipek Gokhan 
Published: May 2022

Abstract

Objectives
Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis.

Methods
In this study, 100 severe CAD patients who had undergone the coronary artery bypass graft surgery and 100 healthy controls were genotyped for OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants via RT-PCR.

Results
The patients with OLR1 rs11053646 CG + GG genotype demonstrated a higher frequency of multi-vessel stenosis (18%) than single- (11.10%) or double-vessel (13.30%) stenosis (p=0.77). Additionally, although not statistically significant, this group of patients had 6.280 times more CAD risk than CC genotype carriers (p=0.089). Furthermore, logistic regression analysis revealed significant associations between the three variants and the risk factors for CAD development, namely waist circumference (p=0.002), body mass index (p=0.013), fasting glucose level (p=0.006), and triglyceride levels (p=0.035).

Conclusions

OLR1 rs11053646, IL17A rs3819025, and rs8193037 variants do not increase the risk for CAD development. However, this conclusion should be confirmed with a larger cohort.
A Strain-Normalized Serviceability Limit State for the Secondary Seal of Insulating Glass Units with Rigid Box Spacers: Optimizing Serviceability of IGU Seals
Authors: Nizich Adam J. , Sanders Helen E. , Burkhart Kelly L. 
Published: May 2022

Insulating glass unit (IGU) geometries, cavity dimensions, installations, and edge seal forces can vary considerably from those qualified with laboratory test specimens for durability. The life span of an IGU is often limited by the design and fabrication quality of the edge seal system. The durability of IGU edge seal systems in North America is evaluated with standardized laboratory weathering tests for the established IGU specimen dimensions and glass compositions specified in ASTM E2190. For edge seal design of structurally glazed dual-sealed IGUs, the secondary seal contact width for a selected edge seal system is based on the minimum dimension qualified in the ASTM E2190 test specimen and the calculated capacity to resist wind load per ASTM C1249. The contact width of the secondary seal is currently evaluated for capacity to resist wind load without an application-specific review of edge seal durability—that is, there is no method to ensure that predicted environmental forces, such as cavity loads, do not cause excessive strain in the primary sealant that would accelerate moisture vapor transmission and gas loss substantially above that experienced by the IGU laboratory test specimen.
A serviceability limit state is proposed for design of the secondary seal of dual-sealed IGUs with a rigid box spacer to achieve a comparable polyisobutylene (PIB) strain to that experienced by IGUs when tested according to ASTM E2190 (strain-normalized performance). This paper describes an evaluation of IGU edge seal structural mechanics with finite element analysis. On the basis of our results, we suggest that service-level design capacity is a function of PIB strain (rather than structural sealant stress) for long-term cavity loads and is the governing limit state for IGU edge seal design. This is an initial step in the development of an analytical method to engineer IGU edge seals for serviceability.
Self-sensing asphalt composite with carbon microfibers for smart weigh-in-motion
Authors: Birgin Hasan Borke , D’Alessandro Antonella , Corradini Alessandro , Laflamme Simon , Ubertini Filippo 
Published: May 2022

AbstractThe need for ageing infrastructure monitoring has recently emerged as an urgent priority in many countries. Smart road infrastructure is a technology that could be used to address this issue by enabling on-time decisions such as condition-based maintenance. For example, automatic traffic monitoring could be beneficial by improving fatigue analysis, and maintenance priority planning and management of overloaded vehicles. This can be done through image-based traffic monitoring, weight measurements by static scales, and weigh-in-motion (WIM) stations. WIM can be used to identify and classify the type, the number, and the weight of vehicles passing over a given road segment without interrupting the traffic flow. The general drawbacks of existing WIM technologies are their high costs, low durability, and complex deployment. This paper proposes a new asphalt-like composite enabling self-sensing road pavements that can serve as a low-cost and durable WIM sensor. The proposed novel material consists of a commercial binder called EVIzero, doped with natural aggregates and carbon microfibers. These microfibers provide electrical conductivity and piezoresistive properties through electrical percolation. Here, both the material preparation for road applications and its electromechanical characterization are examined. Various cylindrical samples fabricated using different percentages of carbon microfibers were produced and investigated in order to evaluate their signal quality and strain sensing capabilities. It is found that the material mix fabricated with 1% carbon microfibers with respect to the binder weight has the best sensing performance due to electrical percolation. A mid-size slab sample is produced using this optimal mix in order to achieve a preliminary demonstration of material’s feasibility for WIM sensing. The results show that a linear relationship between the electrical response of the slab sample and the induced strain is established with an $$R^2$$

R
2

of 93%.
ARTIST’S IRON-BASED NATURAL EARTH PIGMENTS OF TUSCANY (MONTE AMIATA VOLCANO, ITALY)
Authors: VEZZOLI LUIGINA , PRINCIPE CLAUDIA 
Published: May 2022

ABSTRACT
Among the artist’s iron-based natural earth pigments, the so-called terra di Siena (raw sienna), terra di Siena bruciata (burnt sienna) and terra d’ombra (umber) have been among the yellow-brown and reddish-brown earth pigments most widely used by Italian and European painters since the Renaissance. We present the history of discovery, designation, and production of these famous pigments, their geological, lithological, and geochemical characterization, and the recognition of their genesis and places of origin, based on new geological field surveys, and on the critical analysis of textual documents and rock sample collections assembled during the eighteenth and nineteenth centuries. In particular, the terra di Siena earth pigment exclusively originated at, and was extracted from, late Pleistocene paleo-lake basins surrounding the Monte Amiata volcano. This earth pigment consists of primarily lacustrine sediments composed of hydrated iron oxide (limonite/goethite) produced by biochemical authigenic precipitation from fresh waters rich in metal solutes.
Proteozom inhibitörü Carfilzomib’in multipl miyelom hücrelerinde piroptozis hücre ölüm yolağı üzerine olan etkisi
Authors: AKÇORA YILDIZ Dilara , BAYKAN Yakuphan , AŞIK Fadime 
Published: May 2022

Amaç: Multipl miyelom (MM), monoklonal antikor salgılayan anormal plazma hücrelerinin kemik iliğinde aşırı birikimi ile karakterize bir B hücre malignitesidir. Klinik uygulamalarda ikinci nesil proteozom inhibitörü carfilzomib (CFZ), relaps veya tedaviye dirençli hastaların tedavi rejimlerinde kullanılmaktadır. Ancak, MM hücrelerinde CFZ’in tetiklediği hücre ölümü mekanizmaları tam olarak aydınlatılamamıştır. Bu çalışmanın amacı, MM hücrelerinde CFZ’in apoptotik olmayan düzenli hücre ölüm yolaklarından biri olan piroptozis üzerine olan etkisinin araştırılmasıdır.
Yöntem: İnsan RPMI 8226, U266 ve NCI H929 MM hücre hatları, CFZ’in IC50 dozları ile 48 saat süre boyunca muamele edildi. Muamele edilen hücrelerde piroptozisin önemli substratları olan GSDMD ve GSDME ile Bax ve Bcl-2 genlerinin mRNA düzeylerindeki farklılıklar kantitatif eş zamanlı PCR (qPCR) yöntemiyle belirlendi.
Bulgular: NCI H929 ve RPMI 8226 hücrelerinde CFZ uygulamasının hem GSDMD hem de GSDME mRNA düzeylerinde anlamlı artışa neden olduğu belirlenirken, U266 hücrelerinde ise sadece GSDME mRNA seviyesinde anlamlı bir artış tespit edildi (p
Age specific references for anti-mullerian hormone and use as a potential diagnostic marker of PCOS in an Indian population
Authors: Vijayan Abinaya , Shankar K M Kundavi , Geetha  
Published: May 2022

: Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder of reproductive age characterized by anovulatory infertility and diagnosed by Rotterdam criteria. The International evidence based guidelines for PCOS, confirms that raised levels of anti-Müllerian hormone (AMH) in patients with PCOS but lack of cutoff values in different age groups is limited. Hence the present study was aimed to determine a cutoff value of AMH in different age groups that could facilitate potential diagnostic marker of PCOS Chennai, India.: A total of 800 women aged 20 to 40 years, including 139 (17.3%) PCOS patients and 160 eumenorrheic non-hirsute control women were prospectively enrolled in this study between May 2020 and July 2021. The Rotterdam criteria were used for diagnosis of PCOS. The cut-off levels of AMH in different age categories were estimated, using the Bayesian method. Mann-Whitney and Chi-square statistical analysis were done for the variables.: Out of139 PCOS patients, 38/139 (27.3%) aged 20-25 years, 35/139 (25.1%) aged 26-30 years, 32/139 (23%) aged 31-35 years and 34 (24.4%) aged 36-40 years. Mean AMH concentrations in women with PCOS was higher 5.24 ± 3.61 ng/mL in comparison to controls 2.51 ± 1.74 ng/mL. The cutoff levels of PCOS in the age categories of 20-25, 26-30,31-35 and 36-40 years were 5.6 (95% CI: 5.20–6.18), 5.3 (95% CI: 5.14–4.28), 4.03 (95% CI: 3.55–4.42) and 3.52 (95% CI: 3.72–3.27), respectively.: Serum AMH concentration &#62;3.52 ng/mL could be used as cutoff value as a potential diagnostic marker of PCOS in all age group. Further, studies needed with more PCOS patients to identify the reference intervals of serum AMH according to age groups and can be used an additional marker for PCOS diagnosis.