bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the COVID-19 pandemic on children's mental health: A systematic review
Authors: Ng Catalina Sau Man , Ng Sally Sui Ling 
Published: October 2022

BackgroundThe outbreak of COVID-19 in December 2019 has caused unprecedented disruption to the structure of children's daily lives due to school closures, online learning, strict social distancing measures, limited access to outdoor activities and many other restrictions. Since children are more susceptible to stress than adults and there is a growing concern about the potential debilitating consequences of COVID-19 for children's mental health, the present review aims to provide empirical evidence on the groups who are most at risk of mental health problems and uncover the risk and protective factors of children's mental health.MethodsA systematic search was performed, in accordance with PRISMA guidelines, in the electronic databases Web of Science (including SSCI and A&amp;HI) and EBSCOhost (including ERIC, MEDLINE and APA PsycArticles and APA PsycINFO), for any empirical studies published between January 2020 and February 2022 that focused on children ≤ 12 years old.ResultsAn initial search identified 2,133 studies. A total of 30 studies fulfilled the inclusion criteria and were analyzed. The evidence showed that many children were affected by the COVID-19 pandemic and experienced internalizing and externalizing behaviors. Worsened child mental health outcomes reflected socioeconomic inequalities as most at-risk children had parents with low educational attainment, were from families of low socioeconomic status and lived in small homes. Key risk factors were identified, including unhealthy lifestyle behaviors (extended screen time, sleep disturbances and less physical activity), increased pandemic-related stressors among parents and deteriorated mental health of parents, which were directly or indirectly associated with the pandemic safety measures, such as home confinement or social distancing. Protective factors including parents' resilience, positive parent-child relationship and school connectedness in relation to children's mental health were reported.ConclusionThe overall results highlight the urgent need for the implementation of tailor-made interventions for children with signs of internalizing and externalizing behaviors. Health promotion and prevention strategies by the government to maintain the mental health of children, particularly those from lower SES families who are at higher risk of worsened mental health are essential for post-pandemic policies.
Gleason score, surgical and distant metastasis are associated with cancer-specific survival and overall survival in middle aged high-risk prostate cancer: A population-based study
Authors: Cao Guangbiao , Li Yan , Wang Jinkui , Wu Xin , Zhang Zhaoxia , Zhanghuang Chenghao , Han Keqiang 
Published: October 2022

ObjectiveAccording to statistics, patients with high-risk prostate cancer (PC) account for about 15% of prostate cancer diagnoses, and high-risk patients usually have a poor prognosis due to metastasis and recurrence and have a high mortality rate. Therefore, the accurate prediction of prognostic-related risk factors in middle-aged high-risk PC patients between 50 and 65 can help reduce patient mortality. We aimed to construct new nomograms for predicting cancer-specific survival (CSS) and Overall survival (OS) in middle-aged high-risk PC patients.MethodsData for patients aged between 50 and 65 years old and diagnosed with high-risk PC were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression models were used to identify independent risk factors for CSS and OS in patients. Nomograms predicting CSS and OS were developed based on multivariate Cox regression models. The concordance index (C-index), the area under the receiver operating characteristic curve (AUC), and the calibration curve are used to detect the accuracy and discrimination of the model. Decision curve analysis (DCA) is used to detect the potential clinical value of this model.ResultsBetween 2010 and 2018, 1,651 patients diagnosed with high-risk PC and aged 50–65 years were included. In this study, the training group (n = 1,146) and the validation group (n = 505) were randomly assigned in a ratio of 7:3. The results showed that M stage, Gleason (GS) and surgical mode were independent risk factors for CSS; marital status, T stage, M stage, surgical mode, and GS were independent risk factors for OS. The C-index for predicting CSS in the training and validation groups are 0.84 and 0.811, respectively; the C-index for predicting OS in the training and validation groups are 0.824 and 0.784, respectively. The AUC and the calibration curves also showed good accuracy and discrimination.ConclusionsWe constructed new nomograms to predict CSS and OS in middle-aged high-risk PC patients. The prediction tools showed good accuracy and reliability, which can help clinicians and patients to make better clinical decisions.
Evidence-based core information for health communication of tobacco control: The effect of smoking on risks of female disease
Authors: Liu Jin , Hao Yun-Yi , Mao Hui-Jia , Sun Xiang-Ju , Huang Xiao-Lu , Quan Chen-Xin , Cao Mei-Ling , Wei Shu-Ting , Jin Xue-Zheng , Wu Yi-Bo 
Published: October 2022

ObjectiveCigarettes have become the the biggest killer of contemporary female's health and beauty. What kind of health information is suitable for the general public is an important issue to be discussed globally. The purpose of this study is to generate systematic, rigorous, public-demand-oriented and appropriate core information relevant to tobacco control based on the best available evidence, combined with audience preferences and pre-dissemination content review from multidisciplinary expertise in order to improve the effectiveness of health communication of tobacco control.MethodsRelevant systematic reviews meta-analysis that reported smoking on risks of female disease were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, Clinical Trials.gov, and the International Clinical Trial Registry Platform. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) process was applied to assess the evidence in order to make rigorous core information. The audience prevalence survey was conducted to ensure that core information was targeted and tailored. Finally, the expert assessment was used for a pre-dissemination content review and to evaluate whether the core information was appropriate or not.ResultsThe final core information consisted of eight parts concerning the effects of smoking and female cardiovascular disease, diabetes, rheumatoid arthritis, respiratory disease, digestive system disease, mental disease, non-pregnant female reproductive system disease, as well as pregnant women and their fetuses. A total of 35 items of core information suitable for dissemination was included and the quality of evidence, the degree of public demand and the outcome of pre-dissemination content review were reported.ConclusionThe core information related to female cardiovascular system diseases, as well as liver cancer and upper gastrointestinal cancer is the preferred content for health communication of tobacco control. The quality of evidence for core information related to pregnant women and their infants, as well as diseases of reproductive system, respiratory system, and diabetes needs to be improved to meet high public demand. The core information related to mental disease is more suitable for dissemination to patients with mental illness than to the general public. Besides, dissemination of core information should be individualized. Evidence-based Core Information for Health Communication of Tobacco Control would be helpful to provide evidence support for health communication related to tobacco control and enhance public health literacy for international communities that have high smoking prevalence and related disease burden.
Use of the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework to guide iterative adaptations: Applications, lessons learned, and future directions
Authors: Glasgow Russell E. , Battaglia Catherine , McCreight Marina , Ayele Roman , Maw Anna M. , Fort Meredith P. , Holtrop Jodi Summers , Gomes Rebekah N. , Rabin Borsika Adrienn 
Published: October 2022

IntroductionImplementation science frameworks have been used widely for planning and evaluation, but seldom to guide adaptations during program implementation. There is great potential for these frameworks to be used to inform conceptual and data-driven decisions about adaptations.MethodsWe summarize recent applications using Iterative RE-AIM to capture and guide adaptations. Iterative RE-AIM can be repeated at multiple time points customized to each project and involves the following activities: identification of key implementation partners; rating importance of and progress on each RE-AIM dimension (reach, effectiveness, adoption, implementation, and maintenance); use of summary data on ratings to identify one or two RE-AIM dimensions for adaptations and implementation strategies; and evaluation of progress and impact of adaptations. We summarize recent and ongoing Iterative RE-AIM applications across multiple care coordination and pain management projects within the Veterans Health Administration, a hypertension control trial in Guatemala, a hospital-based lung ultrasound implementation pilot, and a colorectal cancer screening program in underserved communities.ResultsIterative RE-AIM appears feasible, helpful, and broadly applicable across diverse health care issues, interventions, contexts, and populations. In general, the RE-AIM dimension showing the largest gap between importance and progress has been Reach. The dimensions most frequently selected for improvement have been Reach and Implementation. We discuss commonalities, differences and lessons learned across these various applications of Iterative RE-AIM. Challenges include having objective real time data on which to make decisions, having key implementation staff available for all assessments, and rapidly scoring and providing actionable feedback. We discuss print and online resources and materials to support Iterative RE-AIM.ConclusionsThe use of Iterative RE-AIM to guide and support understanding of adaptations has proven feasible across diverse projects and in multiple case studies, but there are still questions about its strengths, limitations, essential components, efficiency, comparative effectiveness, and delivery details. Future directions include investigating the optimal frequency and timing for iterative applications; adding contextual assessments; developing more continuous and rapid data on which to make adaptation decisions; identifying opportunities to enhance health equity; and determining the level of facilitation that is most cost-effective.
Sub-surface plasma flows and the flare productivity of solar active regions
Authors: Lekshmi B. , Jain Kiran , Komm Rudolf W. , Nandy Dibyendu 
Published: October 2022

The extreme space weather conditions resulting from high energetic events likes solar flares and Coronal Mass Ejections demand for reliable space weather forecasting. The magnetic flux tubes while rising through the convection zone gets twisted by the turbulent plasma flows, energizing the system and resulting in flares. We investigate the relationship between the subsurface plasma flows associated with flaring active regions and their surface magnetic flux and current helicity. The near-surface horizontal velocities derived from the ring-diagram analysis of active region patches using Global Oscillation Network Group Doppler velocity measurements are used to compute the fluid dynamics descriptors like vertical divergence, vorticity and kinetic helicity used in this work. The flaring active regions are observed to have large value of vertical vorticity and kinetic helicity. Also, the horizontal flow divergence, vorticity, flux, kinetic and current helicities are observed to be significantly correlated and evolve in phase with each other. We observe that the integrated values of the above flow and magnetic parameters observed 1 day prior to the flare are significantly correlated with the integrated flare intensity of the active region. Hence, we show that strong vorticity/kinetic helicities lead to larger active region twisting, presumably generating high-intensity flares.
Distal and proximal control of rhythmic gene transcription
Authors: Román-Figueroa Abraham , Tenorio-Hernández Luis , Furlan-Magaril Mayra 
Published: October 2022

The circadian clock synchronizes the temporal activity of physiological processes with geophysical time. At the molecular level circadian rhythms arise from negative feedback loops between activator and repressor transcription factors whose opposite and rhythmic activity at gene promoters sustains cyclic transcription. Additional epigenetic mechanisms driving rhythmic transcription involve dynamic remodeling of the proximal and distal chromatin environment of cyclic genes around the day. In this context, previous studies reported that thousands of enhancer elements display rhythmic activity throughout the 24 h and more recently, 3C-based technologies have shown that circadian genes establish static and rhythmic contacts with enhancers. However, the precise mechanisms by which the clock modulates gene topology are yet to be fully characterized and at the frontier of chronobiology. Here we review evidence of the proximal and long-distance epigenetic mechanisms controlling circadian transcription in health and disease.
Plasma Extracellular Vesicles-Derived miR-99a-5p: A Potential Biomarker to Predict Early Head and Neck Squamous Cell Carcinoma
Authors: Huang Qiang , Shen Yu-Jie , Hsueh Chi-Yao , Zhang Yi-Fan , Yuan Xiao-Hui , Zhou Yu-Juan , Li Jiao-Yu , Lin Lan , Wu Chun-Ping , Hu Chun-Yan 
Published: October 2022

Purpose: This study aimed to investigate the applicability of plasma extracellular vesicles (EVs) miR-99a-5p as a potential head and neck squamous cell carcinoma (HNSCC) diagnostic biomarker.Methods: The miRNA expression of HNSCC tissue and plasma EVs were profiled by small RNA sequencing. qRT-PCR was performed to detect miR-99a-5p expression in HNSCC (n = 93) and benign disease (n = 39) plasma EVs and formalin-fixed and paraffin-embedded (FFPE) tissue (n = 110). We constructed receiver-operating characteristic curves to investigate the diagnostic efficiency of plasma EVs miR-99a-5p.Results: Tumor tissue exhibited lower miR-99a-5p than para-tumor tissue. Patients with high miR-99a-5p expression exhibited significantly more p16 positive status. In contrast, HNSCC plasma EVs harbored more miR-99a-5p than the benign disease group. Plasma EVs miR-99a-5p distinguished HNSCC with area under the curve (AUC) of 0.7494 (95% CI: 0.6692–0.8296; p &lt; 0.0001), with 61.54% sensitivity and 75.27% specificity, respectively. Furthermore, plasma EVs miR-99a-5p also distinguished early HNSCC with AUC of 0.7394 (95% CI: 0.6284–0.8504; p = 0.0002), with 79.07% sensitivity and 61.54% specificity, respectively.Conclusion: Plasma EVs miR-99a-5p is a potential biomarker for predicting early HNSCC.
Effect of Currently Available Nanoparticle Synthesis Routes on Their Biocompatibility with Fibroblast Cell Lines
Authors: Mansoor Afsheen , Khurshid Zohaib , Mansoor Emaan , Khan Muhammad Talal , Ratnayake Jithendra , Jamal Asif 
Published: October 2022

Nanotechnology has acquired significance in dental applications, but its safety regarding human health is still questionable due to the chemicals utilized during various synthesis procedures. Titanium nanoparticles were produced by three novel routes, including Bacillus subtilis, Cassia fistula and hydrothermal heating, and then characterized for shape, phase state, size, surface roughness, elemental composition, texture and morphology by SEM, TEM, XRD, AFM, DRS, DLS and FTIR. These novel titanium nanoparticles were tested for cytotoxicity through the MTT assay. L929 mouse fibroblast cells were used to test the cytotoxicity of the prepared titanium nanoparticles. Cell suspension of 10% DMEM with 1 × 104 cells was seeded in a 96-well plate and incubated. Titanium nanoparticles were used in a 1 mg/mL concentration. Control (water) and titanium nanoparticles stock solutions were prepared with 28 microliters of MTT dye and poured into each well, incubated at 37 °C for 2 h. Readings were recorded on day 1, day 15, day 31, day 41 and day 51. The results concluded that titanium nanoparticles produced by Bacillus subtilis remained non-cytotoxic because cell viability was >90%. Titanium nanoparticles produced by Cassia fistula revealed mild cytotoxicity on day 1, day 15 and day 31 because cell viability was 60–90%, while moderate cytotoxicity was found at day 41 and day 51, as cell viability was 30–60%. Titanium nanoparticles produced by hydrothermal heating depicted mild cytotoxicity on day 1 and day 15; moderate cytotoxicity on day 31; and severe cytotoxicity on day 41 and day 51 because cell viability was less than 30% (p < 0.001). The current study concluded that novel titanium nanoparticles prepared by Bacillus subtilis were the safest, more sustainable and most biocompatible for future restorative nano-dentistry purposes.
DEM Study on Hydrological Response in Makkah City, Saudi Arabia
Authors: Hidayatulloh Asep , Chaabani Anis , Zhang Lifu , Elhag Mohamed 
Published: October 2022

The changes in catchments can be analyzed through the generation of DEM, which is important as input data in hydrologic modeling. This study aims to analyze the effect of anthropogenic activities on hydrological studies based on DEM comparison and GIUH hydrographs. The four DEM datasets (SRTM, ALOS, Copernicus, Sentinel-1) were compared to the topographic map of Makkah City and GPS data in order to assess the quality of the DEM elevation. The GIS Arc Hydro toolbox was used to extract morphometric and Horton–Strahler ratio characteristics to generate a GIUH hydrograph of the catchments of Wadi Nouman and Wadi Ibrahim inside Makkah City. Based on the DEM comparison, Copernicus and SRTM have the highest accuracy, with R2 = 0.9788 and 0.9765, and the lowest RMSE, 3.89 m and 4.23 m, respectively. ALOS and Sentinel-1 have the lowest R2, 0.9687 and 0.9028, and the highest RMSE, 4.27 m and 6.31 m, respectively. GIUH Copernicus DEM on Wadi Nouman has a higher qp and lower tp (0.21 1/h and 2.66 h) than SRTM (0.20 1/h and 2.75 h), respectively. On Wadi Ibrahim, the SRTM has a greater qp and lower tp than Copernicus due to the wadi having two shapes. Based on the anthropogenic effect, the stream network in the mountain area is quite similar for SRTM and Copernicus due to the dominant influence of the mountainous relief and relatively inconsequential influence of anthropogenic activities and DEM noise. In the urban area, the variation of the stream network is high due to differing DEM noise and significant anthropogenic activities such as urban redevelopment. The Copernicus DEM has the best performance of the others, with high accuracy, less RMSE, and stream flow direction following the recent condition.
The Effect Of Cupping On Blood Pressure In Hypertension
Authors: Rohayu Santoso Budi , Ketut Wahyudi  , Sampari Gerbab IHA  
Published: October 2022

Pressure blood tall Becomes a problem only when blood pressure is persistent because it makes system circulation and organs that receive blood supply (including heart and brain) tense. one therapy trusted cupping can lower blood pressure. The research objectives are to analyze the effectiveness of cupping to change pressure blood sufferer hypertension. Study this use method study quantitative with type study pre-experimental design. In a study, this is a total of 30 sufferers Coming hypertension went to the clinic house Nur syifa therapy and did not use the drug hypertension. Respondent gets action measurement pressure blood before conducting action cupping. Respondent gets therapy cupping not enough for 3-5 minutes, then measured repeat pressure of the blood after action cupping. Data analysis using the Wilcoxon test. Results show that cupping is effective for lower pressure blood (p-value <0.001), and pressure blood experienced a decrease in average post cupping 1.45 points _ with effect size in the category large (1.0). Therapy cupping is capable lower blood pressure. Future research could compile therapy with other therapies to reduce antihypertensive drugs that cause resistance or affect medicine.
Legislation of the countries of the European Region on the drinking water quality management (overview)
Authors: Тюрина И.А. , Лебедь-Шарлевич Я.И. , Манаева Е.С. 
Published: October 2022

Качественная питьевая вода является залогом здоровья и благополучия населения. Формирование требований к водоподготовке способствует обеспечению качества и безопасности питьевой воды. Проведен обзор основных подходов законодательного регулирования и нормативно-правовой базы в области обеспечения качества питьевой воды в странах Европейского региона. Рассмотрены требования к качеству питьевой воды, реагентам, материалам и оборудованию, применяемым в системах питьевого водоснабжения, а также требования к их сертификации в странах Европейского союза и России. Отмечено, что, несмотря на наличие национальных нормативов и стандартов, происходит гармонизация требований, предъявляемых к продукции для питьевого водоснабжения, в рамках крупных объединений государств (Европейский союз и Евразийский экономический союз).
High-quality drinking water has been a guarantee of the health and well-being of the population. Formation of the requirements to the water treatment contributes to ensuring the quality and safety of drinking water. A review of the main approaches of the legislative regulation and the legal framework in the field of drinking water quality assurance in the countries of the European Region was carried out. The requirements to the quality of drinking water, chemicals, materials and equipment used in drinking water supply systems, as well as the requirements to their certification in the EU countries and Russia are considered. It is noted that, despite the availability of the national regulations and standards, a harmonization of the requirements to the products for drinking water supply is taking place within the framework of large associations of states (the European Union and the Eurasian Economic Union).