bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-methicillin resistant and growth inhibitory studies of extract and fractions of leaves of Bryophyllum pinnatum (Lam.) Kurz (Crassulaceae)
Authors: Anie Clement Oliseloke , Ikpefan Emmanuel Oise , Enwa Felix Oghenemaro , Umunade Lucy , Enomate Ejiroghene 
Published: May 2022

Summary

Introduction: Bryophyllum pinnatum is a plant with diverse ethnomedicinal claims yet to be verified scientifically.

Objective: This work was aimed at evaluating the extract and vacuum liquid chromatographic (VLC) fractions of B. pinnatum on methicillin-resistant Staphylococcus aureus (MRSA) and anti-proliferating seed radicle cells of Sorghum bicolor.

Methods: The extract and VLC fractions of B. pinatum were screened phytochemically and subsequently tested against MRSA at concentrations of 3.125–100 mg/ml, while the antiproliferative assay at 1–30 and 1–10 mg/ml.

Results: The extract recorded zone of inhibition of 7.05 mm was only at 100 mg/ml against L20 MRSA strains. While VLC bulked fractions A(1), C (5–7), D (8–9) and E (10) had no zones of inhibition against the strains, fraction B had zones of inhibitions at all concentrations with the highest ones of 9.7 and 8.5 mm at 125 and 62.5 mg/ml, respectively, against MRSA sample (L20). The MIC of the active fraction B was observed at 3.9, 7.8 and 15.6 mg/ml for all samples used. At 96 h of seed incubation, 56 mm radicle length was recorded by the control seeds was reduced to 1.5 mm (97%) and 0.4 mm (99%) when treated with 20 and 30 mg/ml of the extract. The VLC sub-fraction B at 10 mg/ml showed more inhibitory effects on the germinating radicles as it recorded 100% reduction when compared to the control at 96 h against 80 and 70% recorded by fractions ‘A’ and ‘C’, respectively.

Conclusion: The results obtained showed an evidence of susceptibility of methicillin-resistant Staphylococcus aureus and growth inhibitory potentials of B. pinnatum, particularly the active VLC fraction “B”. Thus, further studies are required to support these findings.
Disruption and transformation in media events theory: The case of the Euromaidan Revolution in Ukraine
Authors: Bolin Göran , Ståhlberg Per 
Published: May 2022

Abstract
Media events, Dayan and Katz argue, compose a narrative genre that follows specific structural principles and narrative tropes and that works toward societal integration. However, a specific subset of media events is labelled transformative, and these work towards societal change. In this article, we point to an unresolved tension between transformative events and what has subsequently been introduced as disruptive events. Our discussion builds on research on the developments in post-Soviet Ukraine, and we analyse, firstly, the transformative and disruptive relations related to the so-called Euromaidan Revolution, and secondly, how these events can be placed in a wider narrative of three Ukrainian revolutions. Our analysis concludes that narrative analysis can help explain the ways in which these events are understood by broader international audiences.
Knowledge management by construction management template for sustainable entrepreneurship
Authors: Meneiluik Aleksandr , Nikiforov Aleksey 
Published: May 2022

Abstract
The article is devoted to the development of a new information and communication concept – “construction management template (CMT)”. This concept changes the way knowledge management in construction is due to: taking into account the most effective modern and traditional methods of management; use of information technologies; end-to-end integration of different solutions into one information and communication tool.
CMT is an information and communication model in the form of a three-dimensional parametric part of a building or structure and the associated resource schedule of works used to plan and control management, architectural, technological, operational, and economic decisions throughout the construction project.
Combining different construction solutions and including management innovations, the developed information and communication concept is the latest way to manage knowledge in construction. Development of the information and communication concept CMT takes into account the use of modern software, innovative and most effective traditional methods of managing enterprises of the full investment construction cycle. The practical significance of the results lies in the development of recommendations for: finding and using efficiency reserves in construction management with the help of modern information technologies; development and use of construction management templates for knowledge management.
The obtained results allowed establishing the new method of management in construction increases the accuracy and speed of management influences, while reducing the cost of management. Thus, more sustainable development of construction entrepreneurship is possible.
Investigation of the poor-quality practices on building construction sites in Malaysia
Authors: Olanrewaju Abdul Lateef , Lee Alice Hui Jing 
Published: May 2022

Abstract
Poor quality occurs in >80% of building projects. They can increase the cost of a building by up to 50% and can delay a project by up to 50%. This research investigated the determinants of poor quality on building on-sites. The research developed a questionnaire instrument that included 20 determinants of poor-quality buildings on construction sites based on literature and site visits. The survey forms were administered to construction sites operatives through hand delivery. A total of 80% of the respondents measured that the poor quality of buildings was caused by the 20 determinants. Poor workmanship, non-compliance with requirements/standards, inadequate site management, failure to achieve high-quality standards, and poor-quality materials/components were the major determinants of the poor quality of buildings during construction. This research provides fresh information on the causes and impact of poor quality on the performance of the building sector.
‘Vestiges of the Divine Light’: Girolamo Zanchi, Richard Hooker, and a Reformed Thomistic Natural Law Theory
Authors: Littlejohn Bradford 
Published: May 2022

Abstract
This article assesses Jerome Zanchi’s (1560-90) theory of natural law in relation to that of Richard Hooker’s (1554-1600) by arguing three theses. First, Zanchi’s view of natural law is generally Thomistic, but he expands upon it in a manner similar to his contemporaries, thereby providing further evidence against the increasingly discredited narrative of a Protestant voluntarism dominating early Reformed scholastic thought. Second, Zanchi’s commitment to the Reformed doctrine of total depravity does not represent as drastic a departure from Thomas as might first appear. Third, Hooker’s disagreement with Zanchi on this last point does not, as often argued, result from his own diluted commitment to total depravity, but denotes a more coherent and elegant way of reaching the same Reformed Thomistic synthesis. The historical record suggests that Hooker’s approach proved more influential than Zanchi’s.
‘All Things Are Lawful’: Adiaphora, Permissive Natural Law, Christian Freedom, and Defending the English Reformation
Authors: Dominiak Paul 
Published: May 2022

Abstract
Adiaphora (‘indifferent matters’) and permissive natural law both conceptually pointed towards an arena of liberty in which the individual remained free to take up (or not) particular courses of action. In the Reformation debates over the external regulation of Christian freedom for the maintenance of peace and order, these two concepts became freighted with political significance; but they also in turn shaped attitudes over when and where obedience was due in relation to the civic regulation of liberty. Tudor apologetics deployed both ideas in order to defend the English Reformation, especially the claim of the royal supremacy to have due authority to regulate ecclesiastical affairs in indifferent matters, limiting Christian freedom and requiring obedience. By situating these debates within the context of the conceptual development of adiaphora and permissive natural law from their original philosophical roots through to the Reformation, this article establishes the genealogy of claims that defined such apologetics. After surveying the seemingly intractable dilemmas in the thought of Thomas Starkey and John Whitgift over why obedience to lay ecclesiastical supremacy was due, this article considers the radical return to the permissive natural law traditions of the medieval period in the Elizabethan conformist thought of Richard Hooker. In this return, Hooker supplanted divine permissions and scriptural principles as the guide for the proper regulation of indifferent matters with an appeal to the light of reason as the divine instrument through which binding human laws are made to govern society and limit freedom for the public good, even in the life of the national church.
MMP-2 and MMP-9 gene polymorphisms and risk of head and neck carcinomas
Authors: Schipor Sorina , Zamfir Adina , Gheorghe Dan Cristian , Picu Catalina , Manda Dana 
Published: May 2022

Abstract

Background: Head and neck carcinomas (HNC) account for a majority of ear, nose and throat tumours. They account for 6.3% of all incident malignancies and 6.2 % of all deaths from cancer in Romania in 2020, the fifth most common cancer in this Eastern Europe country. Aim of the study: The aim of our study was to investigate the association between two MMP-2 and MMP-9 promoter gene polymorphisms and head and neck cancer.

Methods. We enrolled 142 subjects, 65 cancer patients, and 77 control subjects and tested them for MMP-2 -735 C/T and MMP-9 -1562 C/T polymorphisms by PCR-RFLP.

Results. Comparison between cancer patients and controls demonstrated the presence of MMP-2 -735 C/T and MMP-9 -1562 C/T in head and neck malignant tumours, with OR = 2.206 (95% CI 1.058-4.599, P = 0.03) for MMP-2 and OR = 2.748 (95% C.I. 1.262-5.981, P=0.009) for MMP-9 gene polymorphism. This means that the presence of T allele could be a risk factor for head and neck cancer development. The analysis included a stratification of studied groups by age and gender.

Conclusions. Both genotypes were associated with a significant risk for head and neck carcinomas in case of the presence of the T allele. MMP-2 -735 C/T (rs2285053) and MMP-9 -1562 C/T (rs3918242) gene polymorphism could be an important genetic marker for head and neck cancer susceptibility. This finding could be useful for genetic screening in head and neck carcinomas.
Associations of serum expressions of miR-499 and sex determining region Y-box 6 with prognosis of acute myocardial infarction patients
Authors: Mao Jing , Wang Bin , Li Yingjia 
Published: May 2022

Abstract

Background: To explore the associations of serum expressions of miR-499 and sex determining region Y-box 6 (SOX6) with major adverse cardiovascular and cerebrovascular events (MACCE) and prognosis of acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI).

Methods: The clinical data of 132 patients diagnosed from February 2016 to October 2019 were collected. Serum miR-499 and SOX6 expressions were detected by RT-qPCR. Optimal cut-off values were determined using receiver operating characteristic curves, based on which patients were divided into low and high miR-499 expression groups, and high and low SOX6 expression groups. Survival curves were plotted using Kaplan-Meier method, and the independent risk factors for MACCE were explored by multivariate logistic regression analysis. A nomogram model was established based on the factors and validated using internal data.

Results: AMI group had higher miR-499 expression and lower SOX6 expression than those of control group (P<0.05). After PCI, miR-499 expression decreased and SOX6 expression increased (P<0.05). Low miR-499 expression group had higher 3-year survival and MACCE-free rates than those of high miR-499 expression group (P<0.05). Low SOX6 expression group had lower 3-year survival and MACCE-free rates than those of high SOX6 expression group (P<0.05). AMI history, LVEF, CK-MB, miR-499 and SOX6 expressions were independent risk factors for MACCE (P<0.05). The nomogram model had high accuracy for predicting overall survival, with a concordance index of 0.742 (95%CI=0.684-0.845).

Conclusions: AMI patients have increased serum expression of miR-499 and decreased expression of SOX6. High miR-499 expression is an independent risk factor for poor prognosis. The established nomogram model can be used to predict the risk of MACCE after PCI.
Matrix-assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry (MALDI-TOF MS) for subgingival bacteriome identification in a group of treated periodontitis patients: a case series
Authors: Lupșe Irina , Flonta Mirela , Ciurea Andreea , Micu Iulia Cristina , Roman Alexandra , Pall Emoke , Popescu Dora Maria , Soancă Andrada 
Published: May 2022

Abstract
Periodontitis is a chronic multifactorial polymicrobial infection, characterized by profound modifications of the composition and proportion of the subgingival microbiota. Microbiological laboratory tests are sometimes used in periodontal diagnosis and monitoring of treatment, but both conventional cultivation methods and molecular techniques have some major drawbacks. Therefore, other performant bacterial identification methods must be considered. The aim of the current study was to use Matrix-assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry (MALTI-TOF MS) analysis in association with bacterial culture method to evaluate the modifications of the subgingival bacterial composition in periodontitis patients, before and after cause-related subgingival therapy. Subgingival plaque samples were collected from periodontal pockets before and after subgingival mechanical instrumentation and adjunctive local antimicrobial applications and were cultured in aerobic and anaerobic conditions. Microbial colonies were further assessed using MALDI-TOF-MS. A total of 36 bacterial strains were isolated from a group of 16 patients. All species from the orange complex were identified by MALDI-TOF MS. A marked reduction of detection frequency was observed in most bacterial strains, including the orange complex after cause-related periodontal treatment. The results of this study indicate that MALDI-TOF MS could be considered an accurate method for oral microbial identification and the cause-related periodontal treatment is useful for reducing the microbial burden.
Non-inhibitory effects of the potent antioxidant C-phycocyanin from Plectonema sp. on the in vitro glycation reaction
Authors: Husain Arbab , Alouffi Sultan , Khanam Afreen , Akasha Rihab , Khan Saif , Khan Mahvish , Farooqui Alvina , Ahmad Saheem 
Published: May 2022

Abstract
When glucose and Amadori products are auto-oxidized, glycation occurs, resulting in the formation of early (Amadori) and late advanced glycation end products (AGEs), as well as free radicals. Glycation and an increase in free radical activity induce diabetic complications. Antioxidant and antiglycation compounds may aid in the prevention of oxidation and glycation. The goal of this study was to assess the antiglycation and antioxidant capacity of C-phycocyanin (C-PC) derived from Plectonema sp. The DPPH (1, 1-diphenyl-2-picrylhydrazyl), nitric oxide, hydroxyl radical scavenging activities and ferric ions reducing antioxidant power (FRAP) assays were used to assess antioxidant activity, while an in vitro bovine serum albumin-methyl glyoxal glycation (BSA-MG) model was used to assess glycation inhibitory potential. Glycation inhibition was measured using a variety of spectroscopic and biochemical parameters, including UV-visible & fluorescence spectroscopy, ketoamine, carbonyl and hydroxymethyl furfural content, as well as free lysine & free arginine estimations. In vitro, C-PC exhibited dose-dependent potent antioxidant activity, but lacked significant antiglycation potential. As a result, it is recommended that further studies be conducted to evaluate the antiglycation potential of C-PC.
The Design and Experimental Analysis of Excavator with Rotor
Authors: Hamidi Beqir , Shala Ahmet 
Published: May 2022

Abstract
In this paper deriving of dynamical model of the load-bearing structure in form of a Trusses of the excavator with rotor is elaborated. Finite Element Methods and real working conditions are used to derive the dynamical model and to perform the local linearization of the dynamic elastic line for the structure of the load-bearing of the excavator with rotor. As carriers with continuous masses were treated the upper bearing structure of the Dynamical model and the truss levels. Finally, in accordance with the requirements of the problem, the degrees of freedom and the reference nodes are selected. The second stage of reduction, represents the final formation of the dynamical model of the load-bearing infrastructure, which however must be more accurate during the dynamic behaviour of the excavator with the rotor. The exposed work with the formation of the dynamic model of the Truss bearing structure, enables the concrete solution of the oscillations of the excavator with rotor. In addition, the model is of a universal character, respectively, can also be used during the formation of the dynamical model of truss carriers in general.
Influence of the Selected Sieving Parameters on the Sieving Efficiency of Material MCC Avicel PH102
Authors: Jezsó Kristian , Peciar Peter 
Published: May 2022

Abstract
Sieving or screening plays a crucial role in the processing of particulate materials. The sieving process is affected by many factors, including the selection of suitable sieving equipment. Several experiments were carried out to examine the influence of three basic sieving parameters on process efficiency. The investigated material was MCC Avicel PH102, which is widely used as an excipient in the pharmaceutical industry. The three mentioned parameters were sample mass, sieving duration, and vibration amplitude. It was necessary to find a suitable method to evaluate screening efficiency.
Adaptation of Dâmbovița Educational Services to Students needs in the Context of the Coronavirus Pandemic
Authors: Ștefan Maria-Cristina , Andreiana Violeta-Andreea , Stoica Georgiana Daniela , Ghibanu Adrian Ionuț 
Published: May 2022

Abstract
The crisis generated by the coronavirus pandemic has led to many problems related to the optimal management of the teaching act. The topic „Adapting Dâmboviţa educational services to the needs of students in the context of the coronavirus pandemic” is topical and has created many debates and suspicions among the population, especially among those directly involved in education. During the school year 2019-2020, a difficult year, in the field of education there were numerous dysfunctions in the provision of quality educational services online. The study details the measures applied by C.S.I. Dâmbovița in adapting educational services to the needs of students.
Combining Pedagogical Methods with Marketing Techniques to Increase Youth Attachment to Educational Institutions
Authors: Furdui Monica , Marcu Laura , Sula Ledia 
Published: May 2022

Abstract
The article discusses the subject of pupils’ attachment to the specialization and the educational institution to which they are enrolled, through the perspective of a double approach: pedagogical and marketing. In both cases, the content of the concept, its role and the means by which it can be supported are presented. At the same time, the theoretical approach is completed by a case study on educational institutions in a locality in Romania, following the way in which the marketing strategy is used to increase the degree of attachment of pupils to these institutions.
Considerations regarding the Accounting of Value Added Tax – National Particularities within the European Context
Authors: Necula Anda Ileana , Manole Andrei Marcel , Şenchea Florea Anca Daniela , Stancu Liţă Izabela 
Published: May 2022

Abstract
The value added tax (VAT) is an indirect tax on consumption, of a general nature, applied to value of economic goods, regardless their final destination, i.e., consumer goods or production means, as well as to the execution of works and providing of services. According to its name, the calculation basis of VAT, paid by the consumer and due by the seller, is the added value related to the last link in the supply chain; this feature ensures the transparency of the tax. VAT is a consumption tax applied to almost all goods and services purchased and sold for use or consumption in the European Union (EU). At Community level, there are standard VAT rules, but their application may differ among countries. In most cases, VAT must be paid for all goods and services at all stages of the supply chain, including sale to the final consumer. Until 1989, Romania applied a single sales tax, followed by the tax on the movement of goods between 1989 and 1992. The latter was replaced by VAT, starting with July 1, 1992, as part of the initial efforts of transition towards the convergence with the applicable tax system within the European context. The introduction of value added tax has determined, in the early stage following the implementation of this measure, the increase of the consumer price index, but later it had a stimulating effect on investments and exports.
ВОКАЛЬНО-ВИКОНАВСЬКА ТВОРЧІСТЬ МОДЕСТА МЕНЦИНСЬКОГО
Authors: Турянський Петро 
Published: May 2022

У статті описані найважливіші події життя і вокально-творчого шляху визначного українського співака, драматичного тенора Модеста Менцинського. Також висвітлено виконання низки вокальних партій і популяризації української народної пісні, творів і обробок Миколи Лисенка на теренах зарубіжжя.
Зазначено, що поряд зі сценічно-виконавською діяльністю Модест Менцинський засновує у Стокгольмі власну вокальну школу, у нього консультуються як співаки-початківці, так і ті, хто, здобувши визнання, намагалися перейняти багатющий досвід Модеста Менцинського з питань сценічної культури, образності, виконавської майстерності, його вагомих знань і умінь у розвитку вокальної техніки.
ПЕДАГОГІЧНІ УМОВИ РОЗВИТКУ ПРОФЕСІОНАЛІЗМУ МАЙБУТНІХ УЧИТЕЛІВ ФІЗИЧНОЇ КУЛЬТУРИ В ПРОЦЕСІ ФАХОВОЇ ПІДГОТОВКИ
Authors: Лун Цуй 
Published: May 2022

У статті запропоновано педагогічні умови розвитку професіоналізму майбутніх учителів фізичної культури у процесі фахової підготовки.
Автором зазначено, що у КНР фізична культура відіграє значиму роль у житті молоді. Багато молодих людей займаються бойовими видами мистецтва.
Виділено педагогічні умови розвитку професіоналізму майбутніх учителів фізичної культури у процесі фахової підготовки, а саме: підбір викладацького складу, здатного до систематичного вивчення особистісних характеристик майбутніх учителів фізичної культури, урахування їхніх індивідуальних творчих можливостей і ціннісних орієнтацій; формування у майбутніх учителів фізичної культури розуміння ролі і сформованості відповідних компетентностей сучасної діагностики свого функціонального стану для вдосконалення професійної майстерності; забезпечення змагальної активності для фізичного самовдосконалення, забезпечення якості фахової підготовленості майбутнього учителя фізичної культури, формування впевненості у своїх фізичних можливостях.