bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone deacetylase inhibitors attenuated interleukin-1β-induced chondrogenesis inhibition in synovium-derived mesenchymal stem cells of the temporomandibular joint
Authors: Liao Wen-ting , Sun Jia-dong , Wang Yun , He Yi-qing , Su Kai , Lu Yun-yang , Liao Guiqing , Sun Yang-peng 
Published: January 2022

AimsIn the repair of condylar cartilage injury, synovium-derived mesenchymal stem cells (SMSCs) migrate to an injured site and differentiate into cartilage. This study aimed to confirm that histone deacetylase (HDAC) inhibitors, which alleviate arthritis, can improve chondrogenesis inhibited by IL-1β, and to explore its mechanism.MethodsSMSCs were isolated from synovium specimens of patients undergoing temporomandibular joint (TMJ) surgery. Chondrogenic differentiation potential of SMSCs was evaluated in vitro in the control, IL-1β stimulation, and IL-1β stimulation with HDAC inhibitors groups. The effect of HDAC inhibitors on the synovium and condylar cartilage in a rat TMJ arthritis model was evaluated.ResultsInterleukin (IL)-1β inhibited the chondrogenic differentiation potential of SMSCs, while the HDAC inhibitors, suberoylanilide hydroxamic acid (SAHA) and panobinostat (LBH589), attenuated inhibition of IL-1β-induced SMSC chondrogenesis. Additionally, SAHA attenuated the destruction of condylar cartilage in rat TMJ arthritis model. IL-6 (p < 0.001) and matrix metalloproteinase 13 (MMP13) (p = 0.006) were significantly upregulated after IL-1β stimulation, while SAHA and LBH589 attenuated IL-6 and MMP13 expression, which was upregulated by IL-1β in vitro. Silencing of IL-6 significantly downregulated MMP13 expression and attenuated IL-1β-induced chondrogenesis inhibition of SMSCs.ConclusionHDAC inhibitors SAHA and LBH589 attenuated chondrogenesis inhibition of SMSC induced by IL-1β in TMJ, and inhibition of IL-6/MMP13 pathway activation contributes to this biological progress. This study provides a theoretical basis for the application of HDAC inhibitors in the treatment of TMJ arthritis. Cite this article: Bone Joint Res 2022;11(1):40–48.
European Cybersecurity Certification Schemes and cybersecurity in the EU internal market
Authors: Stewart Ferguson Donald David 
Published: January 2022

AbstractThe principal question addressed by this paper is: how adequate are the minimum security objectives of the European Union Cybersecurity Act (Regulation (EU) 2019/881) in assisting organisations in the European Union internal market with resisting and recovering from cyber threats? The question is answered by first identifying the scope of the minimum security objectives. Scope identification, performed through legislative interpretation, reveals an integrated system of security objectives with significant gaps. Second, the minimum security objectives are evaluated within a model of cyber attacks from attack reconnaissance to legal proceedings to reveal further significant gaps. Finally, the minimum security objectives are evaluated within five cyber attack scenarios, reflecting the highest ranking cyber threats to the internal market. The simulation analysis accentuates the findings of the model analysis and identifies further significant gaps. In conclusion, the minimum security objectives are found to be largely inadequate in assisting organisations in the European Union internal market with resisting and recovering from cyber threats. The analysis of the adequacy of the minimum security objectives is timely, as the first European cybersecurity certification schemes are currently being designed.
Relationship between adiponectin multimer levels and subtypes of cerebral infarction
Authors: Tagawa Noriko , Fujinami Aya , Natsume Shigeatsu , Mizuno Shigeto , Kato Ikuo 
Published: January 2022

Aim
Serum adiponectin levels are decreased in patients with cerebral infarction. Adiponectin in circulation exists in three isoforms: high molecular weight (HMW), medium molecular weight (MMW), and low molecular weight (LMW) adiponectin. We measured serum levels of total adiponectin and adiponectin multimers (HMW, MMW, and LMW) in patients with cerebral infarction and compared the serum levels of the three adiponectin multimers in stroke subtypes. We also evaluated the clinical value of adiponectin multimer levels as a biomarker for cerebral infarction.

Methods
We assessed a total of 132 patients with cerebral infarctions. The serum levels of total and adiponectin multimers were measured using enzyme-linked immunosorbent assay (ELISA).

Results
The total and HMW adiponectin levels were significantly lower in atherothrombotic infarction (AI) than in cerebral embolism (CE) (total, p < 0.05; HMW, p < 0.05). In male patients, the MMW adiponectin level was significantly lower in the lacunar infarction (LI) group than in the AI group (p < 0.05). The LMW adiponectin level was significantly lower in the AI group than in the LI and CE groups (LI, p < 0.001; CE, p = 0.001). However, there were no significant differences in adiponectin multimer levels among the stroke subtypes in female subjects. Additionally, in female patients with AI and LI, the LMW adiponectin levels were negatively associated with C-reactive protein (CRP; AI, p < 0.05; LI, p < 0.05).

Conclusion
These findings suggest that a decrease in adiponectin is associated with AI and that serum LMW adiponectin level represents a potential biomarker for AI.
Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma
Authors: Suzuki Shinsuke , Toyoma Satoshi , Kawasaki Yohei , Yamada Takechiyo 
Published: January 2022

Background
Cytotoxic effects of radiation play an important role in the treatment of head and neck cancer. However, irradiation is known to lead to the migration of various cancer cells, including those of head and neck cancer. Recently, fibroblasts in the cancer microenvironment have been reported to be involved in this mechanism. Nevertheless, the mechanism underlying migration of head and neck cancer cells remains unclear. Herein, we aimed to elucidate this migration mechanism induced by irradiation in terms of the interaction of head and neck cancer cells with fibroblasts.

Methods
We used the head and neck squamous cell carcinoma (HNSCC) cell lines SAS and FaDu as well as fibroblast cell lines. These cells were irradiated and their viability was compared. In fibroblasts, changes in interleukin-6 (IL-6) secretion caused by irradiation were measured by enzyme-linked immunosorbent assay (ELISA). The cell migration ability of cancer cells was evaluated via a migration assay using a semipermeable membrane. HNSCC cells were cocultured with irradiated and nonirradiated fibroblasts, and their migration ability under each condition was compared. We also examined the effect of IL-6 on the migration of HNSCC cells. Furthermore, to investigate the effect of fibroblast-derived IL-6 on the migration ability of HNSCC cells, we conducted a coculture study using IL-6 neutralizing antibody.

Results
Irradiation reduced the survival of HNSCC cells, whereas fibroblasts were resistant to irradiation. Irradiation also increased IL-6 secretion by fibroblasts. Migration of HNSCC cells was enhanced by coculture with fibroblasts and further enhanced by coculture with irradiated fibroblasts. We also confirmed that the migration of HNSCC cells was induced by IL-6. The enhanced migration of cancer cells caused by coculturing with fibroblasts was canceled by the IL-6 neutralizing antibody.

Conclusion
These results show that fibroblasts survive irradiation and induce the migration ability of HNSCC cells through increased secretion of IL-6.
Los grandes en un mercado de chicos. El abasto de carne en Buenos Aires colonial.
Authors: Dupuy Andrea Lidia 
Published: January 2022

Se ha demostrado que el abasto de carne a la ciudad de Buenos Aires tardo-colonial es un mercado diversificado en el que predominan los medianos y pequeños productores y comercializadores donde las pequeñas transacciones modelan una demanda constante y sistemàtica. Sin embargo, en ese universo se presenta un reducido grupo de “grandes productores” y “grandes abastecedores”, que matizan este universo. Grupo que aparece en los corrales de abasto citadino con un promedio que excede las 100 reses mensuales, destacándose del resto. En el presente estudio intentamos profundizar la identidad de estos actores sociales, teniendo como objetivo principal su identificación a través del estudio de sus características, puntos de acercamiento, asì como su incidencia dentro de este mercado local y de la economía tardo-colonial de Buenos Aires en su conjunto.
Corpo Axé – Um Relato de Experiência Autobiográfico sobre Consciência Corporal de um jovem Umbandista / Axé Body – An Autobiographical Experience Report about Body Counciousness from a Young Umbandista
Authors: Silva Jorge Francisco Sandro Souza 
Published: January 2022

RESUMOO presente artigo trata-se de um relato de experiência autobiográfico a partir da vivência do autor em templo de Umbanda. Apresentando um resgate histórico das religiões afro-brasileiras e tecendo aproximações possíveis entre o corpo numa perspectiva da cosmovisão africana e para a Análise Bioenergética a partir de relatos pessoais. PALAVRAs CHAVE: Consciência corporal; Ancestralidade Africana; Umbanda; Análise Bienergética; Religiões Afro-Brasileiras.
Paternidades Insubmissas: Família QUEER / Unsubmissive Paternities: QUEER Family
Authors: Costa José Amaro da 
Published: January 2022

Resumo: Este artigo foi pensado para dar voz ao que é estigmatizado, muitas vezes silenciado e indesejado pelos defensores de modelos tradicionais quando o assunto é paternidade, educação e família. Para tanto, é necessário dialogar sobre o contexto da experiência paterna separada de uma masculinidade tóxica e hegemônica. Também considerar a liberdade de existências e dar visibilidade e respeito às famílias que transgridem a matriz binária de sexualidades. Destaca-se nesse artigo relatos obtidos através de uma entrevista com dois pais homossexuais que vivem a paternidade via adoção, impulsionando transformações na sociedade.Palavras-chave: Paternidade; Educação; Família Queer. Abstract: This article was designed to give voice to what is stigmatized, often silenced and unwanted by advocates of traditional models when the subject is parenthood, education and family. To do so, it is necessary to dialogue with the context of the paternal experience diverted from a toxic and hegemonic masculinity. Also consider the freedoms of existence and give visibility to families that transgress the binary matrix of sexualities. Highlights in this the reports obtained in an interview with two homosexual fathers who experience fatherhood through adoption, driving transformations in society. Keywords: Fatherhood; Education; Queer Family.
Stein domains in ℂ2 with prescribed boundary
Authors: Tosun Bülent 
Published: January 2022

Abstract
We give an overview of the research related to the topological characterization of Stein domains in complex two-dimensional space, and an instance of their many important connections to smooth manifold topology in dimension four. One goal is to motivate and explain the following remarkable conjecture of Gompf: no Brieskorn integral homology sphere (other than S
3) admits a pseudoconvex embedding in ℂ2, with either orientation. We include some new examples and results that consider the conjecture for families of rational homology spheres which are Seifert fibered, and integral homology spheres which are hyperbolic.
Processing and visualisation of a series of monochromatic images of regions of the Sun
Authors: Vereshchagin Fedor Viktorovich 
Published: January 2022

Abstract
In order to process and visualise the monochromatic images of regions of the Sun obtained with the CCD multichannel spectroheliograph, the freely distributed programs ImageJ and ParaView were chosen and then fine-tuned. This reduced the time required to develop the data processing and visualization software for this instrument and also made it easier to make further corrections and additions to it.
Effect of beating process on the physicochemical and textural properties of meat analogs prepared with Cordyceps militaris fruiting body
Authors: Zou Yuan , Yu Xiaoying , Zheng Qianwang , Ye Zhiwei , Wei Tao , Guo Liqiong , Lin Junfang 
Published: January 2022

Abstract
In the present work, Cordyceps militaris fruiting body was used as protein and natural fibrous structure source to prepare animal free patty. The effects of beating process on the structural and textural properties of patty were also evaluated. The results found that C. militaris fruiting body based patty prepared with beating process, showed bright yellow in color, with a uniform and smooth surface, and without obvious crack, before and after cooking. The beating process disrupted the connective tissues in fruiting bodies, let more protein dissolve, and left the un-soluble fiber structure. This helped to form a fibrous structure and good gel matrix in patty, which mainly contributed to the high hardness, chewiness, adhesiveness, and sensory score. Such C. militaris fruiting body based patties also had a good nutritional quality with high protein and essential amino acid content, as well as a special nutrient of cordycepin.
Some subclasses of analytic functions involving certain integral operator
Authors: Bukhari Syed Zakar Hussain , Noor Khalida Inayat 
Published: January 2022

Abstract
In this paper, we introduce and investigate two new subclasses of analytic
functions with bounded boundary and bounded radius rotations by using a
certain p-valent operator which complies with the known Carlson–Shaffer
operator for

p
=
1

{p=1}

. Both of these operators are heavily explored and have
various applications. We investigate some inclusions results and integral
preserving properties. We also extend the Ruscheweyh and Sheil-Small convolution
preserving properties in the context of these classes. We relate our finding with
the existing known results found in the literature regarding this subject.
Polarization-controlled anisotropy in hybrid plasmonic nanoparticles
Authors: Wang Xujie , Dou Zhenlong , Zhang Chi , Deng FangFang , Lu XiaoLin , Wang ShuangShuang , Zhou Li , Ding Tao 
Published: January 2022

Abstract
Anisotropy has played a critical role in many material systems, but its controllable creation and modulation have been a long-lasting challenge for the scientific communities. Polarization-addressed anisotropy appears more attractive among all approaches due to its excellent controllability, simplicity, and accuracy, but only a limited number of material systems are applicable for such a concept, which are largely focused on oriented growth. Here, we establish a polarization-dependent anisotropic etching system made of Au@oligomer core–shell nanoparticles (NPs). As the oligomer coatings can be photochemically degraded via two-photon photolithography, the plasmonic near-field enhancement supported by the Au NP cores renders much faster degradation of the oligomer shells along the polarization, resulting in anisotropic Au@oligomer hybrid NPs. Such shape anisotropy leads to polarization-dependent photoluminescence with embedded dyes of methylene blue, which can be used as single-particle-based polarization detector. The oligomer lobes capped at the sides of the Au NP can also function as a protection agent for anisotropic photochemical growth of Au NPs, which evolve into Au nanorods and mushrooms with controlled irradiation time. Such polarization-directed etching of oligomer shells has unique advantages of high local-selectivity, controllability, and versatility for on-chip nanofabrication, which opens many new opportunities for integrated nanophotonic devices.
Optical generation of strong-field terahertz radiation and its application in nonlinear terahertz metasurfaces
Authors: Ma Zhenzhe , Li Peiyan , Chen Sai , Wu Xiaojun 
Published: January 2022

Abstract
Extremely nonlinear terahertz (THz)-matter interactions and applications have positioned themselves as the next frontier in quantum information, nonlinear optics, and particle acceleration. However, the absence of free-space highly intense THz sources and the diffraction limit, which prevents THz waves from being concentrated to the nanoscale scale, are inhibiting the growth of extreme THz. To address this difficulty, suitably extremely concentrated THz sources are being produced, while (non-)resonant artificial metastructures are being widely used to enhance local fields, resulting in deep-subwavelength (<λ/103) confinement of highly enhanced THz fields in micro-/nano-gaps. We discuss solid-state stable sources of intense THz radiation generated by femtosecond lasers in this Review, with a special emphasis on the lithium niobate-based tilted pulse front approach and the nonlinear THz metasurfaces allowed by it. Finally, we forecast the field’s future directions in extreme THz research.
Direct generation of entangled photon pairs in nonlinear optical waveguides
Authors: Rodríguez Echarri Álvaro , Cox Joel D. , García de Abajo F. Javier 
Published: January 2022

Abstract
Entangled photons are pivotal elements in emerging quantum information technologies. While several schemes are available for the production of entangled photons, they typically require the assistance of cumbersome optical elements to couple them to other components involved in logic operations. Here, we introduce a scheme by which entangled photon pairs are directly generated as guided mode states in optical waveguides. The scheme relies on the intrinsic nonlinearity of the waveguide material, circumventing the use of bulky optical components and their associated phase-matching constraints. Specifically, we consider an optical waveguide under normal illumination, so that photon down-conversion can take place to excite waveguide states with opposite momentum in a spectral region populated by only two accessible modes. By additionally configuring the external illumination to interfere different incident directions, we can produce maximally entangled photon-pair states, directly generated as waveguide modes with conversion efficiencies that are competitive with respect to existing macroscopic schemes. These results should find application in the design of more efficient and compact quantum optics devices.
The radionuclides contamination in eggs as an environmental marker: a systematic review
Authors: Sadighara Parisa , Mohajer Afsaneh , Shamloo Ehsan , Akbari Nader , Vakili Saatloo Naiema 
Published: January 2022

Abstract
Foods are contaminated with natural and man-made radionuclides. The aim of this systematic review was to determine the amount and type of radionuclides in eggs, as well as the biomarker capability of eggs. The research studies with keywords radionuclide, radioisotopes, contamination and egg were searched in PubMed, Scopus, and Science Direct databases, regardless of publication time. A number of 70 studies were obtained and only 13 articles were finally selected according to exclusion, inclusion criteria and quality assessment results. Studies which detected radionuclide in the hen eggs were selected. The highest frequency of radionuclides belonged to Ra-226 and Cs-137. The index of natural radionuclides is Ra-226 and the index of synthetic radionuclides is Cs-137. The local eggs, in addition to determining food contamination, can also be a good biomarker for identifying environmental contamination.
Exploring aspects of New Work: Spirituality at Work in agile organizations
Authors: Moll Tobias 
Published: January 2022

Abstract
The topic spirituality at work is becoming increasingly important in the scientific management research, while various concepts of and approaches to new work are attracting more and more attention regarding for instance the trend toward a knowledge society, digitalization, increasingly intense competition, and uncertain market and working environments, or aspects of demographic changes especially in corporate practice. These two discussion strands currently run separately; I seek to connect them. I outline the contributions and impacts of the scientific discussion about spirituality at work for the challenges discussed in corporate practice conversation on new work regarding rapid innovation, agility, and continual change, employee retention, and meaning and purpose on the example of the healthcare industry, particularly nursing.
Based on initial results on German employer and employee perspectives on spirituality at work, I show that spirituality at work can positively contribute to employees dealing with uncertainty and persistent change in agile work settings, promote employee creativity, and employee retention and employer attractiveness, especially among younger members of Generation Y. Thus, spirituality at work is a resource for both employees and employers. Finally, I discuss spirituality at works’ double-edged sword character and its suitability for HRM in broadly secularized Germany.
The control effect of dual-frequency ultrasonic excitation on the chaotic oscillation of cavitation bubbles
Authors: Wang Xiaojiao , Ning Zhi , Lv Ming 
Published: January 2022

Abstract
Dual-frequency ultrasonic excitation is not only an important mean of inducing ultrasonic cavitation, but also a key approach to control the oscillation characteristics of cavitation bubbles. In this paper, the control effect of dual-frequency excitation on the oscillation characteristics of cavitation bubbles is studied by means of nonlinear dynamic analyses. The results show that both suppression and promotion of the chaotic oscillation of cavitation bubbles can be achieved by dual-frequency excitation, which deeply depends on the parameters setting (second frequency value, pressure amplitude ratio and phase difference). By increasing the second frequency value, reducing the pressure amplitude ratio and keeping the phase difference within a certain range, the transformation of cavitation bubbles from periodic to chaotic oscillation can be promoted. The results of this paper are of great significance for promoting the highly efficient sonochemical reactions.