bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Risk Factor for Bradycardia in COVID-19 Patients: A Potential Harm of Steroid Treatment
Authors: Ogiwara Misa , Ihara Hiroaki , Haba Manami , Nakazawa Hiroki , Hotta Saori , Jo Hitomi , Hayama Noriko , Honma Yuichiro , Hoshi Sakuo , Fujii Mitsuhiro , Takahashi Kazuhisa 
Published: July 2022

Abstract
The coronavirus disease 2019 (COVID-19) is a condition caused by the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) which first emerged in December 2019. Although several papers have reported the presence bradycardia in patients with COVID-19, the pathophysiology behind this remains unclear. Therefore, we investigated the presence of bradycardia in patients with COVID-19. A total of 153 patients with COVID-19 and 90 patients with influenza who were hospitalized in our hospital from January 1, 2020 to December 31, 2021 and from January 1, 2014 to December 31, 2021, respectively, were enrolled. After adjustment, the incidence of bradycardia and steroid use in patients with COVID-19 were significantly higher than those in patients with influenza (P-value = 0.0067 and P-value = 0.0003, respectively). We then compared the detailed characteristics of patients with COVID-19 to evaluate risk factors for bradycardia. Multivariate logistic regression analysis revealed that steroid use was significantly related to bradycardia (P-value = 0.031; odds ratio [OR]: 3.67; 95% confidence interval [CI]: 1.12–11.96). Overall, results showed a higher incidence of bradycardia in patients with COVID-19 who received steroid treatment. To the best of our knowledge, this is the first report to discuss the potential risk of excessive steroid use patients with COVID-19.
A simplistic approach to the study of two-point correlation function in galaxy clusters
Authors: Qadri Durakhshan Ashraf , Khanday Abdul W. , Ganai Prince A. 
Published: July 2022

Abstract
We developed the functional form of the two-point correlation function under the approximation of fixed particle number density ¯n. We solved the quasi-linear partial differential equation (PDE) through the method of characteristics to obtain the parametric solution for the canonical ensemble. We attempted many functional forms and concluded that the functional form should be such that the two-point correlation function should go to zero as the value of system temperature increases or the separation between the galaxies becomes large. Also, we studied the graphical behavior of the developed two-point correlation function for large values of temperature T and spatial separation r. The behavior of the two-point function was also studied from the temperature measurement of clusters in the redshift range of 0.023 − 0.546.
Effects of Psychological Fatigue on athletes’ Error Related Negativity Based on Artificial Intelligence Computing Method
Authors: LI Jin , Wang Yanni , Li Sihua 
Published: July 2022

Abstract
Psychological fatigue, including mental fatigue and burnout, is a phenomenon that psychological function cannot remain the former level of mental activity. Athletes’ response monitoring ability decreases is up for debate under mental fatigue or burnout circumstances. In Event-related potentials studies, the amplitude of error related negativity decreases. Two experiments were carried out to explore cause-effect relationships of psychological fatigue and response monitoring. The experimental data processing was based on Artificial Intelligence computing methods, including wavelet transform, gray scale transformation and other algorithms. The first experiment was done to explain mental fatigue and response monitoring, 15 participants operated continuously 60 minutes Flanker task, and then operated 15 minutes task accompanied by light music. From the results of behavioral performances, the fatigue period compared with the fatigue-free period showed significant differences, including reaction time(p=0.029) and correct rate(p=0.046). From the results of error related negativity, the amplitude of the fatigue-free period was bigger than that of the music intervention period, the latter was bigger than that of the fatigue period (p<0.001). The second experiment was done to explore burnout and response monitoring, 24 participants were separated averagely into two groups. One group was burnout group, the other group was no burnout group. They operated 15 minutes task. From the results of behavioral performances, no burnout group was better than burnout group. From the results of error related negativity, no burnout group’s amplitude was bigger than that of burnout group, but the difference was marginally significant. The conclusions are as follows: Psychological fatigue (mental fatigue and burnout) weakens athletes’ response monitoring ability, and the effect of mental fatigue is significant.
Numerical Analysis of the Effect of Marangoni Convection in a Shallow Cylinder
Authors: Jory Kurian , Anbalagan Satheesh 
Published: July 2022

Abstract
A numerical study in a two-dimensional, axisymmetric cylindrical geometry is performed to evaluate the effect of Marangoni convection in shallow liquid layers. The test fluid used is silicone oil. The study aims to understand Marangoni convection for a range of temperature gradients (9.0 K, 11.5 K, and 14.0 K), layer depths (4.0 mm, 4.5 mm, and 5.0 mm) under earth gravity (1.0 g), and microgravity (0.5 ×10-3 g) conditions. The finite element method is used to solve the present problem and the numerical models were created using COMSOL V5.6 commercial tool. The influence of fluid meniscus on Marangoni convection is analyzed and found out the thermo-capillary force is less significant in driving the fluid. The present investigation in microgravity ensures the Marangoni convection dominates natural convection. For all the test conditions, it is found that Marangoni convection is influenced more by temperature difference than layer depths. It is observed that the velocity magnitude deviates around 45% for the selected temperatures at 4 mm layer depth, whereas, a 3% deviation is only found between the selected ranges of layer depths at a temperature difference of 11.5 K. From the microgravity study, it is clear that for velocity magnitude at z = 2.5 mm the Marangoni convection contributes to almost 90% of the total convection. It was also observed that the presence of Meniscus will reduce the free surface velocity by almost 60 %.
Predictive Analytics of Economic Factors
Authors: A Sathwik , M Shashank , T Madhusudhan , B.A Raghu 
Published: July 2022

Abstract
The outbreak of the COVID-19 pandemic has affected the world enormously. Along with everything else, theeconomic status of countries has had a major impact, andeverything has come to a standstill. Several important parameterssuch as the GDP rates, unemployment rates, and internationaltrade were highly impacted and if not for the pandemic, thetrends could have been very different.In this study, the focusis to analyze the depth of the impact on various countries andindustries.All the business planning done, be it for a specificproduct launch or implementing a new business model had tobe rescheduled due to the drastic economic changes after thepandemic/lockdown. Although there are many different opinionsof people in this regard, when it comes to business reschedulingall we are looking for is the most ideal alternative time slot insteadof the perfect one. Hence our main goal in this project would betake into account some of the major economic factors/indicatorsof different countries and forecast the same w.r.t each countryconsidered in the data set. If we are able to estimate the metricswith minimum error, we will have a good understanding of howthe economies are shaping up. Our main objective is to analyzethe effect of it , i.e. to analyze the economic pattern and its pathtowards stability . Also, provide a proper predictive model soas to help a lot of decision making groups like Product basedbusiness, few govt institutions.
Activity-based Costing of Caries Treatment Done Under General Anaesthesia
Authors: Sockanathan Loshini , Kuppusamy Elavarasi , Teo Rufinah , Dom Tuti Ningseh Mohd , Aizuddin Azimatun Noor , Yazid Farinawati 
Published: July 2022

Abstract
Background
Activity-based costing (ABC) is a micro costing method. The concept of ABC is production of service consumes activities and these activities consume resources. The objective of this study is to conduct an ABC of common treatments for caries management done under general anaesthesia (GA) among paediatric patients at Hospital Canselor Tuanku Muhriz (HCTM), Malaysia.
Methods
ABC was conducted through clinical pathway to lay out the routine activities of dental caries management done under GA among paediatric patients, analyse each activity, gather information about the equipment, instruments and consumables used, personnel involved, and the time spent for each procedure.
Results
Based on the clinical pathway conducted, patient flow can be divided into ward care, anaesthesia procedure and dental procedure. 10 common treatments for caries management conducted under general anaesthesia identified. The price range of treatment ranges from USD 15 to USD 100. Pulpotomy has the highest cost whereas extraction of teeth has the lowest cost.
Conclusion
Study on costing is important to reduce the gap between the demand in dental treatment and the limited resources available to perform the treatment. ABC is deemed to be appropriate to be used in this study as dental treatment is largely procedural-based and this costing method will produce a a more precise and transparent data. The outcome of this data provides a tool for other hospitals to be used as a standardised approach for treating these patients and subsequently improve the quality of dental care given.
Preparation and characterization of acrylic resins with bio-active glasses
Authors: Raszewski Zbigniew , Chojnacka Katarzyna , Mikulewicz Marcin 
Published: July 2022

Abstract
The aim of this study was to prepare a bioactive acrylic material by adding different glasses. Materials and methods: Commercially available thermally polymerized acrylic resin was mixed with 4 different glasses (Biomin F, Biomin C, S53P4 and 45S5) in 10% concentration in powder and cured. The flexural strength, sorption, and solubility of the samples were tested according to ISO 20795-1:2013. Furthermore, the materials were placed in artificial saliva pH = 4 and 7. Elution was performed over a period 0/1/28 and 42 days. The collected samples were analyzed with optical emission inductively plasma spectrometry ICP-OES for the detection of Ca, P, and Si ions and by ion chromatography for F measurements.Results: The materials obtained after modification with special glasses had lower compressive strength compared to those of pure polymethyl methacrylate, but all the results met the normative requirements. Two glasses have higher solublity values compared to ISO standard. Glass Biomin C can deliver Ca-11.96±1.79, P-25.88±3.88 and Si- 4.43±0.6 [mg/l]-after 28 days at pH 4. Material S53P4 released Ca-6.17±0.92, P-28.57±4.29 and Si-10.85±1.63 after 42 days.Conclusion: - Acrylic resins modified with 10% of Biomin C and S53P4 glasses can be a valuable source of calcium and phosphate ions in acid conditions for period 28 and 42 days.
Microanatomy of the metabolic associated fatty liver disease (MAFLD) by Single- Cell Transcriptomics
Authors: li duo , Zhou Kebing , Wu Qing , Zhu Lingping , Hu Yang , Zhang Haiyan , Peng Jinling , Huang Yichao , Yang Xuefeng , Wang Lijun 
Published: July 2022

Abstract
Background: As a major cause of liver disease worldwide, metabolic associated fatty liver disease (MAFLD) comprises non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Due to the high prevalence and poor prognosis of NASH, it is critical to understand its mechanisms. However, the etiology and mechanisms remain largely unknown. Methods: We first identified differential genes in NASH by single-cell analysis of the GSE129516 and expression profiling data analysis of the GSE184019 dataset from the GEO database. Then single-cell trajectory reconstruction and analysis, immune gene score, cellular communication, key Gene Screening, functional enrichment analysis, and immune microenvironment analysis were carried out. Finally, cell experiments were performed to verify the role of key genes in NASH. Results: We show transcriptome profiling of 30,038 single cells—including hepatocyte and non-hepatocyte—from normal and steatosis adult mouse liver. Comparative analysis of hepatocyte and non-hepatocyte revealed pronounced heterogeneity as well as specific utilization of non-hepatocyte types as major cell-communication hubs. The results showed that Hspa1b, Tfrc, Hmox1 and Map4k4 effectively distinguish NASH tissues from normal samples. The results of scRNA-seq and qPCR indicated that the expression levels of hub genes in NASH were significantly higher than in normal cells or tissues. Further immune infiltration analysis showed significant differences in Macrophages M2 distribution between healthy and metabolic associated fatty liver samples. Conclusions: Our results suggest that Hspa1b, Tfrc, Hmox1 and Map4k4 are all potential biomarkers for NASH diagnosis and prognosis may also be potential therapeutic targets for NASH.
Study on the runoff sediment transport rate of two planting modes under the influence of rainfall
Authors: wang Dongdong 
Published: July 2022

Abstract
In order to explore the impact of ecological planting pattern on runoff sediment transport rate(T2), this study in two planting modes with a single planting of Prunella vulgaris (A) and P. vulgaris and earthworms (B) were investigated through simulated rainfall experiments in the field. The results showed that: 1) T2 decreased first and then stabilized with the rainfall duration,which is dominated by the composition of soil particle size and runoff depth;2) T2 under gentle slope and steep slope conditions is greatly affected by rainfall intensity and slope, respectively; 3) T2 ,which has a good correlation with runoff separation rate (D2), needs to be explained in conjunction with soil properties or raindrop kinetic energy. The main controlling factors of T2 in bare slope, B, A are raindrop kinetic energy, D2, and organic matter, which explain 93.10%, 95.76%, and 98.65%.Compared with B, A has obvious economic and ecological value.
Research on Analyzing Runoff and Simulating Erosion on the Grassland
Authors: Wang Dongdong 
Published: July 2022

Abstract
Grassland runoff is related to soil and water conservation, but there are few related studies. In this study, a simulated rainfall experiment was carried out, and the results showed that: 1) The runoff depth increases with the increase of rainfall intensity and decreases with the increase of slope or cover, all of which can be described by linear equations; 2). Soil specific gravity, root fractal dimension and grass dry weight can explain 5.00%, 31.08%, and 6.64%, respectively;3). The NSE of the grassland erosion model established by rain intensity, flow discharge and cover is 0.700, which is 0.142 larger than that of the grassland erosion model established by rain intensity and flow discharge.The research conclusions will help prevent and control floods, improve water resource utilization and strengthen grassland erosion monitoring.
Personality traits affect anticipatory stress vulnerability and coping effectiveness
Authors: Schlatter Sophie , Louisy Simon , Canada Brice , Thérond Corentin , Duclos Antoine , Blakeley Chris , Lehot Jean-Jacques , Rimmelé Thomas , Guillot Aymeric , Lilot Marc , Debarnot Ursula 
Published: July 2022

Abstract
Objective: The present study aimed at investigating the influence of personality on both anticipatory stress vulnerability and effectiveness of coping strategies in a real-life context. Methods: Following assessment of individual personality traits (Big Five Inventory), 147 volunteers were exposed to the anticipation of a stressful event. Anxiety and cardiac reactivity were assessed as markers of vulnerability to anticipatory stress. Then, participants were randomly assigned to three groups and subjected to a 5-min intervention: relaxing breathing, relaxing breathing combined with cardiac biofeedback, and control. The effectiveness of coping interventions was determined through the cardiac coherence score achieved during the intervention. Results. Higher neuroticism was associated with higher anticipatory stress vulnerability, whereas lower conscientiousness and extraversion were related to lower anticipatory stress vulnerability. Relaxing breathing and biofeedback coping interventions contributed to improve the cardiac coherence in all participants, albeit with greater effectiveness in individuals presenting higher score of openness to experience.Conclusions. The present findings demonstrated that personality traits are related to both anticipatory stress vulnerability and effectiveness of coping interventions. These results bring new insights into practical guidelines for stress prevention by considering personality traits. Specific practical applications for health professionals, who are likely to manage stressful situations daily are discussed.
Preparation and drug loading behavior of pH-responsive Fe3O4/CMCS/ALS magnetic nanoparticles
Authors: Liu Qian , Chen Shilin , Tan Zhenrong , Cen Qiulan , Yang Dongjie , Zheng Dafeng 
Published: July 2022

Abstract
In order to improve the utilization of anti-tumor drugs, a magnetic delivery system for targeted drug was reported. Firstly, aminated modified sodium lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) were used to fabricate nano Fe3O4 to obtain pH-responsive Fe3O4/CMCS/ALS magnetic nanoparticles. Then the magnetic nanoparticles were loaded with doxorubicin hydrochloride (DOX), realizing the targeted delivery and controlled release of anti-tumor drugs. It was found that the amount of crosslinking agent and emulsifier were the key factors affecting the morphology and size of the magnetic nanoparticles. Under optimized conditions, the particle size was about 79.9 ~ 169.9 nm, exhibiting excellent drug loading capacity, good magnetic and pH responsiveness, with an isoelectric point of 4. When the drug-to-material ratio was 11:10, the DOX loading rate and the encapsulation rate of the nanoparticles was 48.68% and 86.23%. While the Fe3O4/CMCS/ALS-DOX could release 63.14%, 56.71%, and 14.28% of DOX at pH 4, 5.3, and 7.4, respectively. The results showed that the Fe3O4/CMCS/ALS particles exhibited excellent drug loading and release behavior based on the pH responsiveness, which could be described by Langmuir adsorption model and Fick's law of diffusion respectively. MTT assay and Live/dead staining experiments also showed that the drug-loaded particles had obvious growth inhibition on cancer cells. So it could be used as a potential drug carrier.
Comparison of unilateral and bilateral percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures with scoliosis
Authors: Liu Zixiang , Li Hanwen , Tang Yingchuang , Liu Hao , Zhang Junxin , Chen Hao , Yang Huilin , Zhang Kai , Chen Kangwu 
Published: July 2022

Abstract
Objective: To assess the clinical effectiveness and radiographic results of unilateral and bilateral percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures (OVCF) associated with scoliosis.Methods: 52 patients who had OVCF with scoliosis and underwent PKP were retrospectively analyzed. Among the patients, 26 cases were incorporated in unilateral PKP group and 26 cases in bilateral PKP group. The operation time, injected cement volume and frequency of intraoperative fluoroscopy were recorded and compared. Visual analogue scale (VAS) and oswestry disability index (ODI) scores, postoperative complications including bone cement leakage and adjacent vertebral fractures were also assessed.Results: Compared to that in bilateral PKP group, the injected cement volume, operation time and frequency of intraoperative fluoroscopy were significantly lower in unilateral PKP group. The VAS scores, ODI scores, average vertebral height and kyphotic angle (KA) were obviously improved after surgery in each group, but there is no difference between the 2 groups in these clinical parameters before and after operation. Furthermore, proportion of cases with bone cement leakage in unilateral PKP group was significantly lower than that in bilateral PKP group. During the follow-up, there were 3 cases (11.5%) in unilateral PKP group and 2 cases (7.7%) in bilateral PKP group who suffered adjacent vertebral fractures, but there was no statistically significant difference between the two groups. (p>0.05).Conclusion: For treating patients with OVCF accompanied by spinal scoliosis, both unilateral PKP and bilateral PKP can effectively relieve acute back pain and correct the KA. However, unilateral PKP has more advantages in shortening operation time, reducing fluoroscopy frequency and bone cement leakage.
Facial age estimation based on multi-task learning and label distribution learning
Authors: He Jianhui , Hu Chunlong 
Published: July 2022

Abstract
Facial age estimation was promising for a wide range of applications in security access control, biometrics, recommender systems, and human-computer interaction.Current age estimation methods based on a priori label distribution learning often used Gaussian distribution as the true distribution of age. However, the Gaussian distribution affects the personalized representation of label classes. In this paper,We proposed an age encoding called MPD (Multi-Peak Distribution) to fuse the prior distributions of apparent and true ages for label distribution learning. Specifically, we used label shifting to construct the apparent age distribution. A lightweight multi-task learning network was designed to perform both label distribution learning and regression learning. Unlike traditional label distribution learning cascade networks, the parallel structure was able to reduce the error propagation from predictive distribution to regression.Extensive experimental analyses on three benchmark datasets demonstrate the superior performance of the proposed method.
Intraoperative cone-beam CT during the transjugular intrahepatic portosystemic shunt procedure
Authors: Huang Kai , Liu Yiming , Wei Qiuliang , Xu Kaihao , Han Xinwei , Jiao Dechao 
Published: July 2022

Abstract
To evaluate the identification of portal vein (PV) entry by intraoperative cone-beam CT (CBCT) during the transjugular intrahepatic portosystemic shunt (TIPS) procedure. From February 2018 to February 2020, 73 patients underwent TIPS due to severe portal hypertension, and 28 of them underwent intraoperative CBCT angiography. In the CBCT and digital subtraction angiography (DSA) groups, the primary indicators included the number of punctures, PV puncture time, and PV entry scoring and the secondary indicators included shunt angle (SA), contrast volume, and dose area product (DAP) were evaluated, respectively. The number of punctures and PV puncture time in the CBCT group were (2.3 ± 0.9) and (9.2 ± 1.8) min that both less than (4.2 ± 1.5) and (20.4 ± 2.1) min in the DSA group, respectively, and PV entry scoring was better in the CBCT group (all P < 0.05). The DAP was (224.3 ± 46.3) Gy×cm2 in the CBCT group and (180.9 ± 29.3) Gy×cm2 in the DSA group, which showed a significant increase (P < 0.05). However, SA and contrast volume showed no significance between the two groups. Intraoperative CBCT can accurately identify PV entry for some difficult TIPS procedures but results in increased radiation exposure.