bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect Evaluation of Norepinephrine on Cardiac Function in Patients with Sepsis by Cardiac Ultrasound Imaging
Authors: Zhou Wei , Li Yuyu , Yang Baocheng , Wang Xianjun 
Published: June 2022

In order to investigate the therapeutic effect of norepinephrine on patients with sepsis and the effect of echocardiography on the diagnosis of cardiac function in patients with sepsis, 86 patients with sepsis were selected as research objects and randomly divided into two groups. Patients in the control group (

N
=
43

cases) received conventional treatment (1~15 μg/

kg
∗
min

dopamine), and those in the experimental group (

N
=
43

cases) received conventional treatment+norepinephrine therapy (0.05~0.5

μ
g
∗
kg

-1/min). The clinical efficacy, cardiac ultrasonography results, and hemodynamic indexes of patients between the two groups were analyzed and compared. The results showed that the total effective rate of treatment in the experimental group (97.7%) was significantly higher than that in the control group (81.4%) (

P
<
0.05

). The maximum, minimum, and average values of mitral valve E peak flow velocity (VEpeak) and left ventricular outflow tract peak flow velocity (Vpeak), respiratory variability of mitral valve E peak flow velocity (ΔVEpeak), and respiratory variability of peak flow velocity (ΔVpeak) were all significantly greater than those of the control group (

P
<
0.05

). The area under the receiver operating characteristic curve (AUC) of ΔVEpeak and ΔVpeak for predicting positive volume response in patients with sepsis was 0.934 and 0.913, respectively; the sensitivity was 0.828 and 0.827; the specificity was 0.936 and 0.893; and the Youden indices were 0.765 and 0.712, respectively. In short, norepinephrine had a high total response rate in patients with sepsis, and echocardiography can well evaluate the effect of norepinephrine on cardiac function in patients with sepsis, which is worthy of further promotion.
Cardiovascular and Limb Events Following Endovascular Revascularization Among Patients ≥65 Years Old: An American College of Cardiology PVI Registry Analysis
Authors: Weissler E. Hope , Wang Yongfei , Gales Jordan M. , Feldman Dmitriy N. , Arya Shipra , Secemsky Eric A. , Aronow Herbert D. , Hawkins Beau M. , Gutierrez J. Antonio , Patel Manesh R. , Curtis Jeptha P. , Jones W. Schuyler , Swaminathan Rajesh V. 
Published: June 2022

Background
We aimed to characterize the occurrence of major adverse cardiovascular and limb events (MACE and MALE) among patients with peripheral artery disease (PAD) undergoing peripheral vascular intervention (PVI), as well as associated factors in patients with chronic limb threatening ischemia (CLTI).

Methods and Results
Patients undergoing PVI in the American College of Cardiology’s (ACC) National Cardiovascular Data Registry’s PVI Registry who could be linked to Centers for Medicare and Medicaid Services data were included. The primary outcomes were MACE, MALE, and readmission within 1 month and 1 year following index CLTI‐PVI or non‐CLTI‐PVI. Cox proportional hazards regression was used to identify factors associated with the development of the primary outcomes among patients undergoing CLTI‐PVI. There were 1758 (49.7%) patients undergoing CLTI‐PVI and 1779 (50.3%) undergoing non‐CLTI‐PVI. By 1 year, MACE occurred in 29.5% of patients with CLTI (n=519), and MALE occurred in 34.0% of patients with CLTI (n=598). By 1 year, MACE occurred in 8.2% of patients with non‐CLTI (n=146), and MALE occurred in 26.1% of patients with non‐CLTI (n=465). Predictors of MACE at 1 year in CLTI‐PVI included end‐stage renal disease on hemodialysis, congestive heart failure, prior CABG, and severe lung disease. Predictors of MALE at 1 year in CLTI‐PVI included treatment of a prior bypass graft, profunda femoral artery treatment, end‐stage renal disease on hemodialysis, and treatment of a previously treated lesion.

Conclusions
Patients ≥65 years old undergoing PVI experience high rates of MACE and MALE. A range of modifiable and non‐modifiable patient factors, procedural characteristics, and medications are associated with the occurrence of MACE and MALE following CLTI‐PVI.
Systematic Review and Network Meta‐Analysis Comparing Bifurcation Techniques for Percutaneous Coronary Intervention
Authors: Park Dae Yong , An Seokyung , Jolly Neeraj , Attanasio Steve , Yadav Neha , Rao Sunil , Vij Aviral 
Published: June 2022

Background
Bifurcation lesions account for 20% of all percutaneous coronary interventions and represent a complex subset which are associated with lower procedural success and higher rates of restenosis. The ideal bifurcation technique, however, remains elusive.

Methods and Results
Extensive search of the literature was performed to pull data from randomized clinical trials that met predetermined inclusion criteria. Conventional meta‐analysis produced pooled relative risk (RR) and 95% CI of 2‐stent technique versus provisional stent on prespecified outcomes. Both frequentist and Bayesian network meta‐analyses were performed to compare bifurcation techniques. A total of 8318 patients were included from 29 randomized clinical trials. Conventional meta‐analysis showed no significant differences in all‐cause mortality, cardiac death, major adverse cardiac events, myocardial infarction, stent thrombosis, target lesion revascularization, and target vessel revascularization between 2‐stent techniques and provisional stenting. Frequentist network meta‐analysis revealed that double kissing crush was associated with lower cardiac death (RR, 0.57; 95% CI, 0.38–0.84), major adverse cardiac events (RR, 0.50; 95% CI, 0.39–0.64), myocardial infarction (RR, 0.60; 95% CI, 0.39–0.90), stent thrombosis (RR, 0.50; 95% CI, 0.28–0.88), target lesion revascularization, and target vessel revascularization when compared with provisional stenting. Double kissing crush was also superior to other 2‐stent techniques, including T‐stent or T and protrusion, dedicated bifurcation stent, and culotte.

Conclusions
Double kissing crush was associated with lower risk of cardiac death, major adverse cardiac events, myocardial infarction, stent thrombosis, target lesion revascularization, and target vessel revascularization compared with provisional stenting and was superior to other 2‐stent techniques. Superiority of 2‐stent strategy over provisional stenting was observed in subgroup meta‐analysis stratified to side branch lesion length ≥10 mm.
Two-Way Teleconnections between the Southern Ocean and the Tropical Pacific via a Dynamic Feedback
Authors: Dong Yue , Armour Kyle C. , Battisti David S. , Blanchard-Wrigglesworth Edward 
Published: June 2022

Abstract
Despite substantial global mean warming, surface cooling has occurred in both the tropical eastern Pacific Ocean and the Southern Ocean over the past 40 years, influencing both regional climates and estimates of Earth’s climate sensitivity to rising greenhouse gases. While a tropical influence on the extratropics has been extensively studied in the literature, here we demonstrate that the teleconnection works in the other direction as well, with the southeast Pacific sector of the Southern Ocean exerting a strong influence on the tropical eastern Pacific. Using a slab ocean model, we find that the tropical Pacific sea surface temperature (SST) response to an imposed Southern Ocean surface heat flux forcing is sensitive to the longitudinal location of that forcing, suggesting an atmospheric pathway associated with regional dynamics rather than reflecting a zonal-mean energetic constraint. The transient response shows that an imposed Southern Ocean cooling in the southeast Pacific sector first propagates into the tropics by mean-wind advection. Once tropical Pacific SSTs are perturbed, they then drive remote changes to atmospheric circulation in the extratropics that further enhance both Southern Ocean and tropical cooling. These results suggest a mutually interactive two-way teleconnection between the Southern Ocean and tropical Pacific through atmospheric circulations, and highlight potential impacts on the tropics from the extratropical climate changes over the instrumental record and in the future.
Gastric Neuroendocrine Tumor Treatment and Survival Outcome Depends on Facility Type
Authors: Platoff Rebecca M. , Lou Johanna , Bush Kathryn , Zhu Clara , Spitz Elizabeth , Gaughan John P. , Atabek Umur , Spitz Francis , Hong Young K 
Published: June 2022

Background Gastric neuroendocrine tumors (gNETs) are rare cancers for which surgery may improve survival. We aim to determine if facility type affects treatment and survival outcomes. Methods The NCDB was queried for patients with gNET from 2004-2016 and stratified into Academic/Research Program (ARP), Community Cancer Program (CCP), Comprehensive Community Cancer Program (CCCP), or Integrated Network Cancer Program (INCP). Overall survival along with clinical and demographic features was compared. Results Median survival was improved in patients treated at an academic program: 137.3 months versus 88.0, 96.3, and 100.2 for CCP, CCCP, INCP, respectively (P < .0001). Patients treated at academic centers were more likely to have surgery (64.2% vs 59.1%, 57.5%, 51.4%, P < .0001). After propensity matching for age, race, grade, stage, insurance status, and comorbidity score, survival benefit from treatment at an academic center remained (P = .03), particularly for patients undergoing surgery (P < .0001) and chemotherapy (P = .04). Conclusion Patients with gNET treated at an academic hospital had improved median survival after propensity matching and may benefit from treatment at academic rather than community medical centers.
Adherence to the American Cancer Society Head and Neck Cancer Survivorship Care Guideline According to Chart Review: A Nested Retrospective Cohort Pilot Study
Authors: Salley Jordan R. , Day Andrew T. , Balachandra Sanjana , Mehr Joshua , Sumer Baran D. , Sher David J. , Mayfield Arnold Elizabeth , Danphuong Ho Esther , Lee Simon Craddock , Eary Rebecca 
Published: June 2022

Objectives:The purpose of this study was to explore adherence to the American Cancer Society (ACS) Head and Neck Cancer (HNC) Survivorship Care Guideline and their outlined 33 recommendations among posttreatment HNC survivors.Methods:A bi-institutional, retrospective, nested cohort study of mucosal or salivary gland HNC survivors diagnosed in 2018 was designed. Guideline adherence was assessed via retrospective chart review between 0 and 13 months after completion of oncologic treatment according to 4 categories: (1) problem assessed, (2) problem diagnosed, (3) management offered; (4) problem treated. Adherence was defined as meeting a recommendation subcategory at least once over the 13-month period.Results:Among 60 randomly selected HNC survivors, a total of 38 were included in the final cohort after exclusion of individuals with ineligible cancers and those who died or were lost to follow-up over the study period. Approximately 95% of HNC survivors were assessed for HNC recurrence and screened for lung cancer. Certain common problems such as xerostomia, dysphagia, and hypothyroidism were screened for and managed in ≥70% of eligible survivors. Conversely, screening for other second primary cancers and assessment of a majority of other physical and psychosocial harms occurred in <70% of survivors, and in many cases none to a slim minority of survivors (eg, sleep apnea and sleep disturbance, body and self-image concerns). Only 5% of survivors received a survivorship care plan.Conclusion:Overall adherence to the ACS HNC Survivorship Care Guideline in early posttreatment survivors was suboptimal. Interventions are needed to better implement and operationalize these guideline recommendations.
Systematic Review of Slide Tracheoplasty Outcomes
Authors: Zalzal Habib G. , Behzadpour Hengameh K. , Leonard James , Sinha Pranava , Preciado Diego A. 
Published: June 2022

Objective: To identify factors predicting success in slide tracheoplasty surgery at a regional children’s hospital and compare with available published literature. Measures: Retrospective chart review comparing demographics (age, weight) and clinical (operative and hospital course, need for additional airway intervention) factors experienced with slide tracheoplasty. Findings were compared with a systematic review of published literature. Results: Of the 16 tracheal stenosis patients in our cohort, 13 (81.3%) presented with an additional congenital or cardiovascular anomaly. When adjusted for cardiovascular anomalies, congenital tracheal stenosis patients had a mean age of 5.2 months (range 6 days-17 months), mean weight of 5.04 kg, and average ICU and hospital length of stay of 31.5 and 36.0 days, respectively. Tracheostomy was required for 4 patients and no early deaths were recorded. Of the 391 children in the grouped cohort, mean age and weight was older at 7.67 months and larger at 5.70 kg. Length of stay in both ICU and overall hospital course was 31.6 and 43.5 days, respectively. Mortality etiology for 44 patients was reported: 17 (38.6%) cardiac-related and 28 (63.6%) late mortalities. Our overall calculated mortality risk of 1.26 ( P < .05) was lower than reported ratios of 2.0+. Conclusion: Despite the numerous institutional studies involving tracheal stenosis, mortality and surgical challenges remain high. Future studies with the inclusion of specific perioperative data can prove to further evaluate correlations between presentation characteristics and mortality.
Development of a High-Fidelity, 3D Printed Otoplasty Surgical Simulator
Authors: Witsberger Chelsey A. , Michaels Ross , Monovoukas Demetri , Cin Mitchell , Zugris Nicholas V. , Nourmohammadi Zahra , Zopf David A. 
Published: June 2022

Importance: Prominotia has functional and esthetic impact for the child and family and proficiency in otoplasty requires experiential rehearsal. Objectives: To design and validate an anatomically accurate, 3D printed prominotia simulator for rehearsal of otoplasties. Methods: A 3D prominotia model was designed from a computed tomographic (CT) scan and edited in 3-matic software. Negative molds were 3D printed and filled with silicone. Expert surgeons performed an otoplasty procedure on these simulators and provided Likert-based feedback. Results: Six expert surgeons with a mean of 14.3 years of practice evaluated physical qualities, realism, performance, and value of the simulator. The simulator was rated on a scale of 1 (no value) to 5 (great value) and scored 3.83 as a training tool, 3.83 as a competency evaluation tool, and 4 as a rehearsal tool. Conclusions: Expert validation rated the otoplasty simulator highly in physical qualities, realism, performance, and value. With minor modifications, this model demonstrates valuable educational potential.
Hikikomori and modern-type depression in Italy: A new phenotypical trans-cultural characterization?
Authors: Orsolini Laura , Bellagamba Silvia , Volpe Umberto , Kato Takahiro A. 
Published: June 2022

Introduction: Hikikomori is a Japanese term etymologically derived from ‘ hiku’ (i.e. ‘ to pull back’) and ‘ komoru’ (i.e. ‘ seclude oneself’), which identifies those subjects who deliberately withdraw themselves by social life, remaining confined into their own home/room. The phenomenon is widely diffused in Japan, even though it is currently spread outside the Japanese culture. However, a universally shared and cross-cultural adaptation of Hikikomori definition, phenomenological and psychopathological characterization is still missing. Methodology: An expert-guided opinion paper was here provided to clinical characterize the Hikikomori-like social withdrawal in the Italian context, by considering the transformation from a family-based society to a ‘fluid’ digital-structured culture, also discussing the concept of modern-type depression. This was provided deepening the principal current studies available in literature and giving an interpretation based on clinical experience in the Italian society. The work was supervised through a consensus by the most international expert of Japanese Hikikomori syndrome. Results: Current individual, family and social trajectories may potentially act as a mediator in favouring the occurrence of Hikikomori-like social withdrawal also in western countries, including Italy. Despite the differences between Japanese and Italian society and culture, the recent shaping of family structure and intra-familial dynamics, typical of the current post-modern society, may potentially influence the emergence of psychopathologies not typical of Italian culture. Unemployment and ‘Not in Employment Education or Training’ (NEET) conditions may represent another potential risk factor for economical/social marginalization of youngsters, together with the recent dramatic emergence of web-based psychopathologies. Conclusion: A diagnostic culturally-adapted flow-chart is proposed for clinical characterizing Hikikomori in Italian context, which may help in proposing preventive strategies, ensuring early identification and prompt therapeutic interventions, particularly among youngsters.
The effect of direct-acting antiviral regimens and telemedicine on the treatment of inmates with hepatitis C virus infection in Israeli prisons
Authors: Richter Vered , Goldstein Liav , Cohen Daniel L , Bermont Anton , Zelnik Yovel Dana , Madar Miriam , Rabinovitch Ron , Shirin Haim , Broide Efrat 
Published: June 2022

Background Direct-acting antiviral (DAA) regimens and telemedicine services are both options for treating hepatitis C virus (HCV) within the prison setting. We aimed to compare factors associated with HCV treatment success over the past decade in Israeli prisons, specifically the influence of DAAs and telemedicine. Methods We retrospectively reviewed the medical records of inmates with HCV infection in Israeli prisons from 2010 through 2020. Demographic, clinical, and laboratory data were recorded, including treatment regimens and success rates. Results A total of 273 inmates were treated; mean age 45 ± 9.36 years; 98.2% males; 63.9% with a history of drug abuse. Advanced fibrosis was documented in 42.9%. The most common genotypes were 1 (46%) followed by 3 (40.7%). Interferon-based regimens were given to 68 inmates between 2010 and 2017. DAA agents were introduced in 2016, with pan-genotype regimens being exclusively used since 2019. Telemedicine services were used in 140 patients (51.3%), starting in February 2019. The sustained viral response (SVR) rate with interferon-based therapy was 78.8% and 98.8% with DAA treatment, giving an overall SVR of 93.2%. This difference between regimens proved to be the only statistically significant predictor of treatment success. The number of prisoners being treated with DAAs increased exponentially after telemedicine was introduced. Comparable SVR rates were achieved with either in-person or telemedicine consultation. Conclusion Screening of this high-risk population and using telemedicine for treatment may be an effective strategy for the elimination of HCV from the prison population.
Production-based solution for interactive healthcare apparels: biomedical applications for topical wound healing
Authors: Cheung Tin Wai , Fu Ying , Li Li 
Published: June 2022

Chitosan, which is a naturally occurring polysaccharide, is known to be a promising component with effective antimicrobial and interactive wound healing properties. However, limitations in the conventional spinning process have restricted the production of chitosan textiles for the development of wound repairing apparels, bedsheets and other textile-based wound care products. Therefore, in scholarly circles, the study of wound healing has mainly focused on nonwoven fabrics and limited attention has been paid to the alleviation of wound conditions on a daily basis by applying chitosan knitted textiles. This study serves as a pilot study associating chitosan knitted fabrics with an interactive wound healing function. Chitosan/cotton blended yarns with different chitosan ratios (5/95 chitosan/cotton and 10/90 chitosan/cotton) were initially spun using the anti-static spinning process and knitted fabrics were made with these yarns. Biological studies, which include an in vitro cell study of dermal repair and animal study of wound healing, were conducted. Significant wound healing ability could be shown even when the yarns consisted of low chitosan ratios. It is believed that the study could provide a new production-based solution for the development of interactive wound healing materials as well as realize the concept of manufacturing topical wound repairing apparel.
Microscopic Over-under Versus Medial Tympanoplasty for Larger Tympanic Membrane Perforations
Authors: Zhang Xiaowen , Ji Caili , Li Aifeng , Xu Zhenju , Zhang Xiaoheng 
Published: June 2022

Objectives To identify the differences in hearing, anatomical success rate, functional success rate, and complications between over-under tympanoplasty and medial tympanoplasty procedures. Methods The clinical data of patients with tympanic membrane perforation repaired by medial tympanoplasty between January 2011 and December 2016 and by over-under tympanoplasty between January 2017 and December 2020 were retrospectively analyzed. We evaluated the differences between medial tympanoplasty and over-under tympanoplasty. Results The overall success rate of over-under tympanoplasty was higher than that of medial tympanoplasty (90.76% vs 81.31%). In large perforations, the success rate of over-under tympanoplasty was higher than that of medial tympanoplasty (89.80% vs 71.43%). There was no statistically significant difference in the success rate between the two treatment groups for moderate perforations. Furthermore, there was no statistically significant difference in the incidence of complications between the two groups ( P = .2637). Conclusions Over-under tympanoplasty is more suitable for large perforations of the tympanic membrane and has a higher success rate as compared to medial tympanoplasty.
The experience of meaning and value in occupations for forced migrants seeking asylum, and factors that facilitate occupational engagement: A meta-ethnography using a strength-based approach
Authors: McGovern Anna , Yong Audrey 
Published: June 2022

Introduction Asylum-seekers face significant barriers to meaningful occupation, leading to negative health and wellbeing outcomes. This study provides a strength-based approach to enhance understandings about the meaning of occupation for those seeking asylum. Method A systematic search of the literature identified seven qualitative research studies. A meta-ethnographic approach was used to synthesise the findings. Results Examination of the selected studies generated three third-order interpretations as follows: keeping busy as a coping mechanism; maintaining continuity with past life by preserving identity, roles, values and culture; and building a new future with a drive to be a productive member of society. The study also identified factors that support meaningful occupational engagement during asylum. Conclusion This study shows that occupations are essential to existence for asylum-seekers. They help preserve identity and life-continuity; help people make sense of disorder in their life; and provide opportunity for reflection, leading to motivation toward goal-directed occupation. Finally, engaging in occupation helps people adjust and cope with trauma. The study highlights that a lack of meaningful occupations may limit the long-term benefits of occupational engagement while seeking asylum. Recommendations are made for further research to challenge restrictive policies and promote the rights and wellbeing of this population.