bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of intra‐firm linkages on firm productivity
Authors: Cho Jaehan , Choi Bo‐Young 
Published: November 2022

AbstractIn this study, we investigate the relationship between intra‐firm linkages and firm productivity using a unique dataset from Korean multinational foreign affiliates. In an empirical analysis, we find that while intra‐firm imports are not statistically associated with productivity on an economy‐wide scale, a positive relationship exists among affiliates in industries with high levels of research and development (R&D) intensity. Our findings show that productivity gains from intra‐firm trade are larger for affiliates in high R&D intensity industries, thus providing evidence that intra‐firm trade is an important channel for knowledge transfer related to R&D for foreign affiliates of multinational corporations.
The two‐child limit and fertility decision making: When policy narratives and lived experiences collide
Authors: Patrick Ruth , Andersen Kate 
Published: November 2022

AbstractThe UK's two‐child limit restricts the child element in Universal Credit and Tax Credits to two children in a household. Given that the policy aims to influence the fertility decision making of parents in (or at risk of) poverty, it is important to explore the impact it has here. This article contrasts the policy rationale for the two‐child limit with everyday realities of fertility decision making. We share new empirical findings from qualitative longitudinal research with parents directly affected by the two‐child limit, contrasting these with the assumptions found in government speeches and statements on the policy. This exploration reveals a series of mismatches, which help explain the relative absence of fertility effects, which has been uncovered in previous quantitative analysis. We show how a government narrative of “choice” over fertility decisions is contradicted by situated realities, where choice is often absent or unresponsive to changes in financial incentives. We also find low levels of awareness of the two‐child limit, militating against it affecting fertility decision making. Our findings demonstrate the importance of better and more sustained engagement with qualitative evidence in the design and review of policies, essential if we are to prevent harms like those witnessed as a result of the two‐child limit.
Transitional care programs in Canada for older adults transitioning from hospital to home: a systematic review of text and opinion protocol
Authors: Barber Brittany , Gregg Emily , Macdonald Marilyn , Moody Elaine , Rothfus Melissa , Weeks Lori E. 
Published: November 2022

Objective:
The objective of this systematic review is to understand what transitional care programs exist across Canada, and to identify the characteristics and outcomes of these programs.

Introduction:
There is growing evidence of the benefits of transitional care programs to support older adults moving from hospital to home. However, there is limited literature identifying the types of transitional care programs that exist internationally, and very little evidence available within Canada.

Inclusion criteria:
Sources of gray literature published from 2016 that focus on older adults receiving services from transitional care programs to move from hospital to home in Canada will be considered for inclusion. Sources of gray literature will be excluded if interventions are targeted at adults younger than 65, Indigenous adults under the age of 55, or whose primary discharge destination is not an independent community dwelling. Interventions designed for older adults waiting in hospital for long-term care placement will also be excluded from this review.

Methods:
An initial limited search of Canadian national gray literature resources will be undertaken, followed by an advanced Google search of Canadian resources and news media reports. Lastly, an advanced search of Google for all 10 provinces and 3 territories will be undertaken to target examples of local transitional care programs that may not be found through a national search, such as local pilot projects, health region–specific programs, and provincial organizations. All identified sources will be retrieved and full text review of selected citations assessed in detail by two independent reviewers. Data about the characteristics and outcomes of transitional care programs and results will be extracted and synthesized using JBI System for the Unified Management, Assessment, and Review of Information (JBI SUMARI), with a meta-aggregation approach for grading according to JBI ConQual method.

Systematic review registration number:
PROSPERO CRD42022298821
Gesture Recognition and Master–Slave Control of a Manipulator Based on sEMG and Convolutional Neural Network–Gated Recurrent Unit
Authors: Ge Zhaojie , Wu Zhile , Han Xu , Zhao Ping 
Published: November 2022

AbstractSurface electromyography signal (sEMG) is the bio-electric signal accompanied by muscle contraction. For master–slave manipulation scenario such as patients with prosthetic hands, their upper limb sEMG signals can be collected and corresponded to the patient's gesture intention. Therefore, using a slave manipulator that integrated with the sEMG signal recognition module, the master side could control it to make gestures and meet their needs of daily life. In this paper, gesture recognition is carried out based on sEMG and deep learning, and the master–slave control of manipulator is realized. According to the results of training, the network model with the highest accuracy of gesture classification and recognition can be obtained. Then, combined with the integrated manipulator, the control signal of the manipulator corresponding to the gesture is sent to the control module of the manipulator. In the end, a prototype system is built and the master–slave control of the manipulator using the sEMG signal is realized.
Problem of Blocking a Technogenic Fracture in the Reservoir Using a Suspension Mixture
Authors: Gil’manov A. Ya. , Fedorov K. M. , Shevelev A. P. 
Published: November 2022

Abstract
The solution of the problem of blocking a technogenic fracture in the reservoir by a suspension mixture is considered. The mathematical model based on the mass conservation laws for the disperse particles and carrier fluid is used. The flow velocity of disperse particles through the fracture is calculated from the Poiseuille law and the carrier fluid outflow to the reservoir is described by Darcy’s law. It is found that the leading front of suspension slug corresponds to a contact discontinuity. It is shown that a reflected wave in the form of a discontinuity of the volume fraction of disperse particles begins to move counter the flow when the front of suspension slug reaches the fracture end and the fracture begins to be blocked up from this end. It is established that the movement of the reverse wave is gradually slowing down; therefore, blocking the entire fracture is turned out to be problematic.
Acute appendicitis and ulcerative colitis: a population-based sibling comparison study
Authors: Garcia-Argibay Miguel , Hiyoshi Ayako , Montgomery Scott 
Published: November 2022

ObjectiveTo assess the inverse relationship between acute appendicitis and ulcerative colitis (UC) using a sibling comparison design to adjust for unmeasured familial genetic and environmental factors.DesignThe cohort comprised 3.1 million individuals resident in Sweden between 1984 and 2018 with the linkage of several Swedish national registers. Fitting Cox hazards models, we calculated the risk for developing UC in individuals with and without acute appendicitis by the age 20 years adjusting for several potential confounding factors. Further, we performed sibling-stratified analyses to adjust for shared unmeasured familial confounding factors.ResultsDuring 57.7 million person-years of follow-up, 20 848/3 125 232 developed UC among those without appendicitis (3.63 (3.59–3.68) per 10 000 person-years), whereas only 59/35 848 people developed UC among those with appendicitis before age 20 years (1.66 (1.28–2.14) per 10 000 person-years). We found a decreased risk for developing UC in those with acute appendicitis by the age 20 years compared with individuals who did not have appendicitis by this age (HR=0.37 (95% CI 0.29 to 0.48)). When adjusting for shared familial confounders, we observed only a slight attenuation in this association (HR=0.46 (95% CI 0.32 to 0.66)).ConclusionIndividuals who had acute appendicitis by late adolescence showed a decreased risk for developing UC compared with those who did not. Genetic and shared familial environmental factors seem to potentially play only a small role in this relationship. Our results suggest an independent association of acute appendicitis, or its underlying causes, with UC risk.
Tracking progress towards universal health coverage for essential health services in China, 2008–2018
Authors: Feng Xing Lin , Zhang Yaoguang , Hu Xuhuai , Ronsmans Carine 
Published: November 2022

IntroductionWe comprehensively evaluate whether the Chinese Government’s goal of ensuring Universal Health Coverage for essential health services has been achieved.MethodsWe used data from the 2008, 2013 and 2018 National Health Services Survey to report on the coverage of a range of Sustainable Development Goals (SDG) indicator 3.8.1. We created per capita household income deciles for urban and rural samples separately. We report time trends in coverage and the slope index (SII) and relative index (RII).ResultsDespite much lower levels of income and education, rural populations made as much progress as their urban counterparts for most interventions. Coverage of maternal and child health interventions increased substantially in urban and rural areas, with decreasing rich-poor inequalities except for antenatal care. In rural China, one-fifth women could not access 5 or more antenatal visits. Coverage of 8 or more visits were 34% and 68%, respectively in decile D1 (the poorest) and decile D10 (the richest) (SII 35% (95% CI 22% to 48%)). More than 90% households had access to clean water, but basic sanitation was poor for rural households and the urban poorest, presenting bottom inequality. Effective coverage for non-communicable diseases was low. Medication for hypertension and diabetes were relatively high (>70%). But adequate management, counting in preventive interventions, were much lower and decreased overtime, although inequalities were small in size. Screening of cervical and breast cancer was low in both urban and rural areas, seeing no progress overtime. Cervical cancer screening was only 29% (urban) and 24% (rural) in 2018, presenting persisted top inequalities (SII 25% urban, 14% rural).ConclusionChina has made commendable progress in protecting the poorest for basic care. However, the ‘leaving no one behind’ agenda needs a strategy targeting the entire population rather than only the poorest. Blunt investing in primary healthcare facilities seems neither effective nor efficient.
Celecoxib versus placebo as an adjunct to treatment-as-usual in children and youth with obsessive–compulsive disorder: protocol for a single-site randomised quadruple-blind phase II study
Authors: Westwell-Roper Clara , Best John R , Elbe Dean , MacFadden Megan , Baer Susan , Tucker Lori , Au Antony , Naqqash Zainab , Lin Boyee , Lu Cynthia , Stewart S Evelyn 
Published: November 2022

Background
Cyclooxygenase (COX) enzymes oxidise arachidonic acid to prostaglandins, which modulate neuronal function and inflammation in the central nervous system. Consensus guidelines suggest non-steroidal anti-inflammatory drugs as a possible adjunctive approach in adults with obsessive–compulsive disorder (OCD) and in children with acute-onset OCD subtypes. However, there is limited evidence to support this approach. The primary objective of this study is to determine the efficacy of the COX-2-selective inhibitor celecoxib as an adjunct to treatment-as-usual in children and youth with moderate-to-severe OCD. The safety of this intervention including adverse events will also be systematically assessed.

Methods
TheAdjunctiveCElecoxib in childhood-onsetOCD(ACE-OCD) study is a single-centre randomised, quadruple-blind, placebo-controlled superiority trial with two parallel groups: celecoxib 100 mg twice daily and placebo. Treatments will be added to participants’ routine clinical care, which will not change over the course of the study. Target recruitment is 80 participants ages 7–18 with no recent treatment changes. The primary outcome is OCD severity after 12 weeks of treatment, measured by clinician-administered Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS). Secondary outcomes include CY-BOCS score after 6 weeks; difference in the proportion of participants achieving a clinically meaningful response or remission; mean clinical global impression of severity and improvement after 6 and 12 weeks; and proportion of participants reporting adverse events possibly or probably related to the study intervention. The primary analyses, carried out according to intention-to-treat principles, will compare the celecoxib to placebo group on each outcome of interest, adjusting for baseline scores using analysis of covariance or logistic regression. Participants will be offered a 12-week open-label celecoxib extension and will be invited to participate in an ancillary study for biomarker analyses.

Ethics and dissemination
This protocol has been approved by the University of British Columbia Children’s and Women’s Research Ethics Board and has received a No Objection Letter from Health Canada. The findings will be disseminated in peer-reviewed journals and presentations to multiple stakeholders including patients, parents and healthcare providers.

Trial registration number

NCT04673578.
Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
Authors: Wallace Sarah , Hall Victoria , Charlett Andre , Kirwan Peter D , Cole Michele , Gillson Natalie , Atti Ana , Timeyin Jean , Foulkes Sarah , Taylor-Kerr Andrew , Andrews Nick , Shrotri Madhumita , Rokadiya Sakib , Oguti Blanche , Vusirikala Amoolya , Islam Jasmin , Zambon Maria , Brooks Tim J G , Ramsay Mary , Brown Colin S , Chand Meera , Hopkins Susan 
Published: November 2022

Introduction
Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection.

Methods and analysis
This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months.
The primary outcome of interest is infection with SARS-CoV-2 after previous SARS-CoV-2 infection or COVID-19 vaccination during the study period. Secondary outcomes include incidence and prevalence (both RNA and antibody) of SARS-CoV-2, viral genomics, viral culture, symptom history and antibody/neutralising antibody titres.

Ethics and dissemination
The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. Participants gave informed consent before taking part in the study.
Regular reports to national and international expert advisory groups and peer-reviewed publications ensure timely dissemination of findings to inform decision making.

Trial registration number

NCT11041050.
Understanding recruitment to a perioperative randomised controlled trial: protocol for a mixed-methods substudy nested within a feasibility trial of octreotide infusion during liver transplantation
Authors: Brodkin Edgar , Loh Ee-Neng , Spiro Michael , Hannon Vivienne , Fabes Jez , Moonesinghe S Ramani , Wagstaff Duncan 
Published: November 2022

Introduction
Recruitment to perioperative randomised controlled trials is known to be challenging. Qualitative methods offer insight into barriers and enablers to participation. This is a substudy within a feasibility randomised controlled trial of octreotide infusion during liver transplantation at two National Health Service hospitals, which will evaluate patient and staff experiences of trial processes. By sharing formative understanding from these methods with the trials team we aim to improve staff–patient interactions and hence recruitment rates.

Methods and analysis
This prospective mixed-methods study will comprise two workstreams. First, after consent to the randomised controlled trial is sought, all patients will be invited to complete a questionnaire to explore their perceptions of the information given to them and motivating factors that influenced their decision to consent or not. Questionnaires will be analysed using descriptive statistics and framework analysis.
If the recruitment:approach ratio drops below a predetermined ratio or if there are any specific recruitment concerns from the trials team, a second workstream involving mixed-methods fieldwork will be implemented. This will involve audiorecording of recruitment consultations and a follow-up semistructured interview to explore patients’ perception of their decision-making regarding recruitment. Semistructured interviews will also be conducted with the recruitment team to establish their views about the trial, barriers to recruitment and ways to overcome them. Recruitment consultations will be analysed using Q-QAT methodology and interviews will be analysed using framework analysis. Findings from both workstreams will be formatively fed back to the trials team to enable iterative improvement to recruitment processes.

Ethics and dissemination
Approval has been granted by Greater Manchester West Research Ethics Committee (ref 20/NW/0071), the Health Research Authority and the local Research and Development offices. A manuscript detailing the summative findings will be submitted to peer-reviewed journals.

Trial registration number

NCT04941911.
Orthodontic interventions as a management option for children with residual obstructive sleep apnea: a cohort study protocol
Authors: Fagundes Nathalia Carolina Fernandes , Perez-Garcia Arnaldo , Graf Daniel , Flores-Mir Carlos , Heo Giseon 
Published: November 2022

Introduction
Obstructive sleep apnoea (OSA) is a sleep-breathing disorder that seems likely to have long-term negative social and health consequences in children and adolescents. There are no established standard management approaches when the first line of therapy, the tonsillectomy and adenoidectomy (T&A), is not indicated or fails to address paediatric OSA (residual paediatric OSA). This protocol describes a prospective cohort study that aims to assess the effectiveness of orthodontic interventions for managing residual paediatric OSA in patients with concomitant craniofacial issues.

Methods and analysis
Children aged 6–16 years who with an OSA diagnosis and did not benefit from previous T&A or qualified for T&A will be recruited. Orthodontic intervention(s), when adequately indicated (maxillary expansion, mandibular advancement or maxillary complex advancement with skeletal anchored headgear), and a control (orthodontic intervention declined) cohorts will be involved. A sample size of 70 participants (n=35 per cohort) is planned. Effectiveness data will be assessed through nocturnal polysomnography, a craniofacial index, sleep questionnaires and medical records. Additionally, the association of residual OSA and two comorbidities, obesity and asthma, will be investigated through assessing blood, urine and saliva metabolites. The changes on body mass index will also be investigated as a secondary outcome. Other additional outcomes, including association between residual paediatric OSA and periodic limbs movement, restless leg syndrome, insomnia, and the use of abiometric shirt to sleep monitoring purposes will also be considered. All participants will be followed up for 12 months after treatment allocation. The effectiveness of the intervention will be analysed by the assessment of sleep parameters, medical history (from medical chart reviews), questionnaire responses, craniofacial characteristics and metabolomic markers using an algorithm to be developed.

Ethics and dissemination
This study was approved by the Health Research Ethics Board-Health Panel, University of Alberta, Edmonton, Canada (Pro00084763). The findings will be shared with scientific and patient content-specific social network communities to maximise their impact on clinical practice and future research in the study topic.

Trial registration number

NCT03821831; Pre-results.
Type of hospitalisations and in-hospital outcomes in the Italian coronary care unit network at the time of COVID-19 pandemic: the BLITZ-COVID19 Registry
Authors: Gulizia Michele Massimo , Fabbri Gianna , Lucci Donata , Di Pasquale Giuseppe , Gabrielli Domenico , Campodonico Jeness , Mauro Andrea , Inciardi Riccardo , Di Lorenzo Emilio , Oliva Fabrizio , Nardi Federico , Colivicchi Furio , De Luca Leonardo 
Published: November 2022

ObjectiveThe aim of the study was to describe the epidemiology and outcome of patients hospitalised during the COVID-19 pandemic in intensive cardiac care units (ICCs).DesignNon-interventional, retrospective and prospective, nationwide study.Setting109 private or public ICCs in Italy.Participants6054 consecutive patients admitted to Italian ICCs during COVID-19 pandemic.Primary and secondary outcome measuresTo obtain accurate and up-to-date information on epidemiology and outcome of patients admitted to ICCs during the COVID-19 pandemic, the impact that the COVID-19 infection may have determined on the organisational pathways and in-hospital management of the various clinical conditions being admitted to ICCs.ResultsAcute coronary syndromes were the most frequent ICC discharge diagnoses followed by heart failure and hypokinetic arrhythmias. The prevalence of COVID-19 positivity was approximately 3%. Most patients with a COVID-19 diagnosis at discharge (52%) arrived to ICC from other wards, in particular 22% from non-cardiology ICCs. The overall mortality was 4.2% during ICC and 5.8% during hospital stay. The cause of in-hospital death was cardiac in 74.4% of the cases, non-cardiovascular in 13.5%, vascular in 5.8% and related to COVID-19 in 6.3% of the patients.ConclusionsThis study provides a unique nationwide picture of current ICC care during COVID-19 pandemic.Trial registration numberNCT04744415.