bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boost short-term load forecasts with synthetic data from transferred latent space information
Authors: Heidrich Benedikt , Mannsperger Lisa , Turowski Marian , Phipps Kaleb , Schäfer Benjamin , Mikut Ralf , Hagenmeyer Veit 
Published: September 2022

AbstractSustainable energy systems are characterised by an increased integration of renewable energy sources, which magnifies the fluctuations in energy supply. Methods to to cope with these magnified fluctuations, such as load shifting, typically require accurate short-term load forecasts. Although numerous machine learning models have been developed to improve short-term load forecasting (STLF), these models often require large amounts of training data. Unfortunately, such data is usually not available, for example, due to new users or privacy concerns. Therefore, obtaining accurate short-term load forecasts with little data is a major challenge. The present paper thus proposes the latent space-based forecast enhancer (LSFE), a method which combines transfer learning and data augmentation to enhance STLF when training data is limited. The LSFE first trains a generative model on source data similar to the target data before using the latent space data representation of the target data to generate seed noise. Finally, we use this seed noise to generate synthetic data, which we combine with real data to enhance STLF. We evaluate the LSFE on real-world electricity data by examining the influence of its components, analysing its influence on obtained forecasts, and comparing its performance to benchmark models. We show that the Latent Space-based Forecast Enhancer is generally capable of improving the forecast accuracy and thus helps to successfully meet the challenge of limited available training data.
miR-454-3p and miR-194-5p targeting cardiac sarcolemma ion exchange transcripts are potential noninvasive diagnostic biomarkers for childhood dilated cardiomyopathy in Egyptian patients
Authors: Fayez Alaaeldin G. , Esmaiel Nora N. , Salem Sohair M. , Ashaat Engy A. , El-Saiedi Sonia A. , El Ruby Mona O. 
Published: September 2022

Abstract
Background
Childhood dilated cardiomyopathy (CDCM) is the most common cardiomyopathy in children and it is risk factor to heart failure and sudden death. Most of the different etiologic factors which have been postulated to DCM are idiopathic, and its pathogenesis remains uncertain. So it was worth investigating the potential DCM pathogenicity models to establish early noninvasive diagnosis parameters especially in CDCM patients. Beside that miRNAs in the circulatory blood are genetically considered the best option for noninvasive diagnosis; also, implementation of miRNAs as early diagnostic markers for children with DCM is urgent because those children have high risk to sudden heart death. We aimed to identify discriminator diagnostic circulatory miRNA expression levels in CDCM patients.

Results
The expression levels of miR-454-3p and miR-194-5p were found significant upregulated (p value = 0.001 and 0.018; CI 95%, respectively), while miR-875-3p was found significant downregulated (p value = 0.040; CI 95%). A receiver operating characteristic (ROC) curve analysis showed significant AUC = 1.000 and 0.798 for miR-454-3p and miR-194-5p, respectively, and the optimal discriminated diagnostic cut-points were computed by index of union (IU) method. Enrichment analysis for the potential targeted mature mRNAs by miR-454-3p and miR-194-5p pointed that Ca, Na and K ions homeostasis in cardiac sarcolemma consider potential CDCM pathogenicity model.

Conclusions
miR-454-3p and miR-194-5p are highly influencing noninvasive biomarkers for CDCM, and further circulatory miRNAs-implicated studies are highly recommended.
The association between nomophobia and loneliness among the general population in the Kingdom of Saudi Arabia
Authors: Hussien Rasha Mohammed 
Published: September 2022

Abstract
Background
Nomophobia progresses through phases (initiation, affirmation, need, and dependency), similarly to addiction, and manifests in a variety of ways, including socially, physiologically, and physically. The objective of the study is to examine the association between nomophobia and feelings of loneliness among a sample of the general population from the KSA. Data were gathered between 5 March and 5 April 2022 using a descriptive, cross-sectional survey design. Five hundred twenty-six participants make up the sample for this study. The information is gathered using a sociodemographic data sheet, Internet usage profiles, a nomophobia questionnaire, and the Loneliness Scale.

Results
The majority of people in the study sample use the Internet for between 4 and 9 h, most immediately in the morning, on waking, for gaming, and for social communication. For nomophobia levels among the study population, the highest percentage is for a moderate level of nomophobia, with the highest means being for factor 1 (unable to communicate), followed by factor 4 (giving up convenience). They also have a moderate level of loneliness.

Conclusions
The multivariate analysis shows that the total loneliness score is strongly and positively correlated with the total nomophobia score and its four factors and the duration of daily mobile Internet use. There are also negative correlations with age and education level. Additionally, the overall nomophobia score has an inverse relationship with income level and age, but a high relationship with the frequency of daily mobile Internet use. The study suggests that there is a need for psychoeducation for a variety of sociodemographic groups to raise awareness about the psychological repercussions of nomophobia, practices that will help to reduce the time spent online for arbitrary reasons, to discover new and entertaining ways of communicating with each other.
Efficacy and safety of direct-acting antivirals for HCV in patients with extrahepatic malignancies: real-life experience
Authors: Atef Mira , Eletreby Rasha , Abdallah Mohamed , Salama Rasha , Elakel Wafaa , Hassany Mohamed , Abdel-Razek Wael , El Shazly Yehia , Doss Wahid , Esmat Gamal 
Published: September 2022

Abstract
Background
Outcome of HCV treatment with direct antiviral agents in malignant patients is questionable. The aim is to assess the safety and efficacy of DAAs in treatment of chronic HCV patients who received chemotherapy for malignancies.

Materials
Retrospective cohort study of 83 patients with HCV post chemotherapy receiving DAAs treatment compared to a matched group of 88 chronic HCV patients without cancer. Demographic, laboratory and abdominal ultrasound data, and SVR were taken for all patients.

Results
Patients’ data revealed mean age (52 years) and BMI (29). A total of 52% of HCV patients were females, and 83.6% were treatment naïve. Patients with cancer had higher FIB4 values and more cirrhosis (20.5% vs. 13.6%) with no statistical significance. Total bilirubin and HbA1C levels were significantly higher in HCV patients without cancer. All patients in either groups received SOF-based DAAs except 2 cases received PAR/OMP/RBV. SVR rate was very high and comparable between the two groups (100% and 97.7% in post chemotherapy and control groups) with no statistical difference. Mortality was represented in 23% in patients post chemotherapy with FIB4 score considered the only predictor for mortality.

Conclusion
DAAs have excellent efficacy in patients post chemotherapy. Further studies should be conducted for their concomitant use with chemotherapy.
Does organizational culture influence employee productivity at the local level? A test of Denison's culture model in Ghana’s local government sector
Authors: Abane Juliana Abagsonema , Adamtey Ronald , Ayim Virceta Owusu 
Published: September 2022

AbstractThere is mixed evidence that low levels of productivity at the local government level are not common with organizations with strong cultures as these are less prone to any externalities. The paper investigated the link between organizational culture and employee productivity from the perspectives of employees of the Sekondi-Takoradi Metropolitan Assembly (STMA) in Ghana. The study used the quantitative approach with descriptive and cross-sectional designs. The simple random and stratified sampling techniques were used to select 132 respondents from the STMA using a self-administered survey questionnaire between August 2020 and December 2020. Denison’s 1984 model of organizational culture was adopted to measure organizational culture while employee productivity was measured by target achievement, available resources and hours of work in a week. With the support of the “SPSS version 22,” the study used descriptive statistics, bivariate analysis and ANOVA tests with hypotheses using standard regression methods. The findings indicate a strong and positive culture of mission, involvement, adaptability and consistency in the STMA. Further, two hypotheses of the study were supported while one hypothesis failed to reject the null hypothesis. However, the relationship between the culture of adaptability and employee productivity was negative but statistically significant; hence, the research hypothesis on this variable was modified to reject the null. Denison’s culture model, which was used to measure organizational culture, was less effective in explaining the variance in the dependent variable as a combined variable.
Development and evaluation of ultradeformable vesicles loaded transdermal film of boswellic acid
Authors: Varia Umang , Joshi Disha , Jadeja Mukesh , Katariya Hitesh , Detholia Krunal , Soni Vishwa 
Published: September 2022

Abstract
Background
Boswellic acid (BA), a phytoconstituent obtained from Boswellia serrata, suffers from several limitations after oral administration such as poor systemic absorption, high first-pass metabolism and high frequency of dose requirement, which creates a need to develop an alternative route for drug administration via novel drug delivery formulation. The present research work aims at developing ultradeformable vesicular carriers (transferosomes) for transdermal delivery of boswellic acid to effectively deliver the drug into deeper layers of the skin reaching the target site and thus improving its systemic bioavailability. Ultradeformable vesicles were prepared by thin-film hydration technique, and the formulation was optimized using 32 full factorial design where the amount of lecithin (mg) and concentration of surfactant (%) were considered as independent variables. The formulated boswellic acid-loaded vesicles were incorporated into transdermal film via solvent evaporation technique using the blend of polymers such as starch and HPMC K4M.

Results
The BA-loaded transferosomes were optimized based on vesicle size (nm) and drug entrapment efficiency (%EE), and the results were found to be 205.4 ± 1.215 nm and 86.39 ± 0.019%, respectively. Transmission electron microscopy (TEM) of optimized batch showed spherical shape of vesicles with identified lamellarity, surface charge of vesicles with high negative value − 15.2 mV that suggests electrostatic repulsion between vesicles, while the formulation showed good deformability index of 11.31 ± 0.032% due to use of Tween 80 as surfactant. In vitro permeation study demonstrated sustained release pattern of 96.53 ± 0.023% up to 24 h. Also, the in vitro drug diffusion study was carried out for transfersomal transdermal film which exhibited enhanced permeation and sustained retention of drug up to 94.71 ± 0.019% for 24 h.

Conclusion
Accordingly, the research work suggested that the transferosomes provided an efficient nanosized carriers for enhanced permeation of boswellic acid into deeper layers of skin and could successfully exhibit its therapeutic effect.
Diagnostic efficacy of ultrasonography-guided fine needle aspiration cytology on thyroid swellings
Authors: Gupta Mudit , Acharya Kunjan , Jha Anamika , Triphati Prashant , Gyawali Bigyan Raj , Bhat Neeti , Pandey Apoorva Kr. 
Published: September 2022

Abstract
Introduction
Patients presenting with a thyroid nodule, if malignant, may call for removal. A good screening tool with high diagnostic value for preoperative evaluation is preferred. Through real-time visualization of the needle to aspirate from the suspicious site, ultrasonography-guided fine-needle aspiration cytology could be an excellent screening tool.

Materials and method
A cross-sectional descriptive study was conducted at Ganesh Man Singh Memorial Academy of Ear Nose Throat–Head and Neck Studies, Kathmandu, Nepal, from September 2018 to November 2019. We included 59 subjects of 15–72 years meeting the inclusion criteria. All study participants underwent preoperative ultrasonography-guided fine-needle aspiration cytological evaluation of thyroid nodule, which was correlated with their histopathological findings to determine diagnostic values.

Result
The sensitivity, specificity, and accuracy of ultrasonography-guided fine-needle aspiration cytology of thyroid nodule was 96.96%, 61.53%, and 81.35%, respectively. On stratification according to size, high sensitivity of 100% was observed in evaluating lesions of size < 2 cm and > 4 cm. There was a good inter-rater agreement between findings of ultrasonography-guided fine-needle aspiration cytology and histopathology with a kappa coefficient of 0.607.

Conclusion
Ultrasonography-guided fine needle aspiration cytology is a reliable procedure to evaluate thyroid lesions with high diagnostic value. It is an excellent tool for evaluating small, non-palpable nodules.
A new shape invariance form of the trigonometric Scarf potential: Two-parameter cross-additivity shape invariance
Authors: Xiong Lulin , Luo Guang 
Published: September 2022

Abstract
Supersymmetric quantum mechanics (SUSYQM) provides an important method for solving the Schrödinger equation rapidly and conveniently. Based on SUSYQM, for the trigonometric Scarf potential, we find that the shape invariance with two parameters shows a new characteristic, i.e., two parameters' cross-additivity

. That is different from the parameters' change

. The changing of the parameters with cross-additivity brings new characteristic to the wave function and energy spectrum. Based on this cross-additivity characteristic, we discuss in detail the eigenvalues and the eigenfunctions of the Hamiltonian with this potential. And then we get the two-parameter cross-additivity shape invariance again with potential algebra methods and study the energy spectrum. It is shown that the two-parameter cross-additivity shape invariance of the partner potential is completely self-consistent with its potential algebraic form. Our research indicates that the Schrödinger equation with a superpotential with two parameters shows new characteristics.
Effect of frequency stabilization on beam shift of total reflection prism laser gyro
Authors: Ma Jiajun , Huang Yueruihan , Liang Yongchao , Jiang Junbiao 
Published: September 2022

Abstract
For the phenomenon of degradation of the performance of total reflection prism laser gyro before and after reset jump, this paper investigates the effect of frequency stabilization on the beam shift of total reflection prism laser gyro using a matrix optics method, and proposes a method to calculate the beam shift with frequency stabilization. The numerical simulation and experimental results show that, unlike the beam shift characteristics caused by the prism temperature, the frequency stabilization additionally causes an approximately equal beam shift at each prism interface, and the shift is proportional to the frequency stabilization control amount. It is pointed out that the large abrupt change of beam propagation path before and after reset jump is the main reason for the degradation of total reflection prism laser gyro performance, and the frequency stabilization control method of reset jump once for each optical wavelength adjustment can effectively reduce the beam shift caused by frequency stabilization.
Diversity and antimicrobial activity of marine nudibranch associated bacteria against tropical human skin pathogens
Authors: Sabdono Agus , Radjasa Ocky , Trianto Agus , Korshunova Tatiana , Martynov Alexander , Sibero Mada 
Published: September 2022

Background: Skin disease is the fourth most common disease among all diseases. The number of cases of skin diseases continues to increase, and people commonly use antibiotics to treat these diseases. Nevertheless, overuse of antibiotics can increase the resistance of these pathogens. Hence, the study of novel antibiotic compounds against multi-drug resistant (MDR) skin pathogens is urgently needed. Methods: This study describes the antimicrobial diversity of bacteria associated with three species of marine nudibranchs (Jorunna funebris, Gymnodoris rubropapulosa, and Glossodoris atromarginata) sampled from Jepara coastal waters, the North Java Sea in August 2020. A total of 115 bacterial strains were selected for their prospective antipathogenic compounds against the pathogens Cutibacterium acnes, Staphylococcus aureus, Candida albicans, and Malassezia furfur. Results: A total of 24 bacterial isolates (20.87%) exhibited antimicrobial activity against the pathogens that were selected and molecularly identified. Analyses of the gene of 16S rRNA discovered that these 24 isolates were associated with 11 genera of the phyla Firmicutes, Proteobacteria, and Actinobacteria, including Bacillus as the dominant genus, followed by Streptomyces, Gordonia, Salinicola, Thalassospira, Halomonas, Dietzia, Brevibacterium, Paracoccus, Pseudovibrio, Pseudoalteromonas, and Pseudomonas. None of the 24 antimicrobial bacterial strains possessed type-1 polyketide synthases (PKS-I). One strain possessed type II polyketide synthases (PKS-II), and five strains possessed non-ribosomal peptide synthetase (NRPS) genes. The amounts of bacterial genus and strains in the three nudibranchs differed significantly, as did the proportions of antimicrobial strains in each nudibranch species. The antibacterial strains isolated from G. atromarginata were the highest number (62.5%), followed by J. funebris (20.8%) and G. rubropapulosa (16.7%). Conclusions: These results demonstrate that nudibranch species harbor prominent and varied communities of bacteria and reveal that many nudibranch-associated bacteria have the potential for the advancement of broad-spectrum antibiotics.
Case Report: Interstitial-intralesional laser therapy and laser-assisted new attachment procedure for the treatment of alveolar bone loss provoked by an aggressive pyogenic granuloma
Authors: Akkarapatum Anon , Klanrit Poramaporn , Sattayut Sajee 
Published: September 2022

Background: A pyogenic granuloma (PG) is a common benign vascular lesion found in the oral cavity. The gold standard treatment of this lesion, comprising surgical excision and the elimination of etiological factors, cannot avoid tooth loss in the case of an aggressive pyogenic granuloma. Because of the prominent properties of 980 nm and 635 nm diode lasers in photocoagulation and photobiomodulation, we applied these wavelengths in the treatment of a large pyogenic granuloma with alveolar bone loss. Case presentation: Our objective was to use a combination of interstitial-intralesional laser therapy, photocoagulation and laser-assisted new attachment procedure (LANAP) to preserve the teeth and periodontal tissue in a case of an aggressive pyogenic granuloma. Results: The patient was a 13-year-old Thai male with a pyogenic granuloma involving the interdental papilla and lingual gingiva of the lower left first and second molars. The teeth were also displaced by the lesion. After treatment with three sessions of photocoagulation, three sessions of interstitial-intralesional laser therapy and two sessions of LANAP, the lesion was completely resolved. The periodontal status of the teeth was improved at the six-month follow-up. Conclusion: The combination of interstitial-intralesional laser therapy, photocoagulation and LANAP was able to treat an aggressive pyogenic granuloma with tooth preservation.
Public perceptions and interactions with UK COVID-19 Test, Trace and Isolate policies, and implications for pandemic infectious disease modelling
Authors: Marshall Guy C. , Skeva Rigina , Jay Caroline , Silva Miguel E. P. , Fyles Martyn , House Thomas , Davis Emma L. , Pi Li , Medley Graham F. , Quilty Billy J. , Dyson Louise , Yardley Lucy , Fearon Elizabeth 
Published: September 2022

Background The efforts to contain SARS-CoV-2 and reduce the impact of the COVID-19 pandemic have been supported by Test, Trace and Isolate (TTI) systems in many settings, including the United Kingdom. Mathematical models of transmission and TTI interventions, used to inform design and policy choices, make assumptions about the public’s behaviour in the context of a rapidly unfolding and changeable emergency. This study investigates public perceptions and interactions with UK TTI policy in July 2021, assesses them against how TTI processes are conceptualised and represented in models, and then interprets the findings with modellers who have been contributing evidence to TTI policy. Methods 20 members of the public recruited via social media were interviewed for one hour about their perceptions and interactions with the UK TTI system. Thematic analysis identified key themes, which were then presented back to a workshop of pandemic infectious disease modellers who assessed these findings against assumptions made in TTI intervention modelling. Workshop members co-drafted this report. Results Themes included education about SARS-CoV-2, perceived risks, trust, mental health and practical concerns. Findings covered testing practices, including the uses of and trust in different types of testing, and the challenges of testing and isolating faced by different demographic groups. This information was judged as consequential to the modelling process, from guiding the selection of research questions, influencing choice of model structure, informing parameter ranges and validating or challenging assumptions, to highlighting where model assumptions are reasonable or where their poor reflection of practice might lead to uninformative results. Conclusions We conclude that deeper engagement with members of the public should be integrated at regular stages of public health intervention modelling.