bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel insights into heme binding to hemoglobin
Authors: Hopp Marie-Therese , Rathod Dhruv Chetanbhai , Winn Kristina Helena , Ambast Shubhi , Imhof Diana 
Published: August 2022

Abstract
Under hemolytic conditions, hemoglobin and subsequently heme are rapidly released, leading to the toxic effects characterizing diseases such as β-thalassemia and sickle cell disease. Herein, we provide evidence that human hemoglobin can bind heme in a transient fashion via surface-exposed sequence motifs. Following the synthesis of potential heme-binding motifs (HBMs) as peptides, their heme-binding capacity was investigated by UV–vis spectroscopy and ranked according to their binding affinity. Heme binding to human hemoglobin was subsequently studied by UV–vis and surface plasmon resonance (SPR) spectroscopy, revealing a heme-binding affinity in the sub- to micromolar range and a stoichiometry that clearly exceeds a 1:1 ratio. In silico molecular docking and simulation studies confirmed heme binding to the respective motifs in the β-chain of hemoglobin. Finally, the peroxidase-like activity of hemoglobin and the hemoglobin-heme complex was monitored, which indicated a much higher activity (>1800%) than other heme-peptide/protein complexes reported so far. The present study provides novel insights into the nature of intact hemoglobin concerning its transient interaction with heme, which suggests for the first time potential heme-scavenging properties of the protein at concomitant disassembly and, consequently, a potentiation of hemolysis and related processes.
Flexural analysis of hemp, kenaf and glass fibre-reinforced polyester resin
Authors: Mohamad Muhammad Aizuddin , Jumahat Aidah , Sapiai Napisah 
Published: August 2022

Abstract
Natural fibres have a high potential to replace synthetic fibres such as glass in a variety of applications. However, natural fibre-reinforced composites still have some limitations with respect to the mechanical performance especially in high load bearing capabilities. The hybridization of natural fibres with synthetic fibres in the same matrix has proven to create a balancing effect and enhanced the composites performance. Besides that, fibre architectures that include fibres continuity, fibres orientation, fibres arrangement and fibres interlocking are also considered to enhance the overall performance of the composites. In this study, the hemp mat, kenaf mat and glass chopped strand mat were hybridised with woven glass fibres, respectively in polyester resin to form 12 systems of the composites. The hybridization effects of different fibre core material, fibre core thickness and fibre arrangement on flexural response were investigated according to ASTM D7264. The results indicated that hybrid CSM glass/woven glass composite showed the highest flexural strength and modulus compared to hemp/woven glass and kenaf/woven glass composites, with about 377.15 ± 48.41 MPa and 16.74 ± 7.15 GPa. Among natural fibres, kenaf fibre (2WG/K/2WG) composite showed better flexural properties compared to hemp fibre (2WG/H/2WG) composite. 2WG/2G/2WG composites with two plies of CSM glass showed maximum flexural properties. As for hemp/woven glass and kenaf/glass hybrid composites, the flexural properties reached a maximum value in system arrangement of (2:1:2) but it reduced in the system arrangement of (2:2:2) and (2:4:2). On the evaluation effect of fibre arrangement, hemp, kenaf and glass mat used as core (arrange in the middle; (2:2:2)) showed higher flexural properties as compared to the use as skin (arrange in outer; (1:4:1)). (2WG/2K/2WG) showed better flexural properties than (2WG/2H/2WG) as the core, while (H/4WG/H) showed better flexural properties than (K/4WG/K) as skin.
Effect of Nano-MgO on the Durability of Cement-Based Materials
Authors: Chen Yaohua , Liu Jiesheng , Feng Bowen , Wei Jing , Tan Xiaoming , Zhang Man , Sun Zhengguang 
Published: August 2022

Abstract
The autogenous shrinkage of cement-based materials is difficult to solve. Some studies have found that nano-magnesium oxide (MgO) can be used as an expansive agent to improve the shrinkage performance of cement-based materials. The basic research on nano-MgO in cement-based materials has appeared, but the research on the durability of cement-based materials by nano-MgO is very rare. In this article, nano-MgO was incorporated into cement mortar, and the experimental research studies effects of nano-MgO content on permeability resistance, crack resistance, sulfate corrosion resistance, and freeze-thaw resistance of cement mortar. The results show that nano-MgO can improve the durability of mortar. The mechanism of nano-MgO is discussed by this article in improving the durability of cement mortar, and it provides a theoretical basis for the further application of nano-MgO in cement-based materials.
Osteosíntesis de fracturas complejas de húmero distal. Nuestra experiencia
Authors: Muñoz Fabián Enrique , Rosso Guiñazu Emmanuel Julio Lisandro 
Published: August 2022

Objetivo: Describir los resultados obtenidos en el tratamiento de las fracturas de húmero distal mediante reducción abierta y fijación interna y reflejar si el abordaje empleado tuvo impacto en el resultado funcional.
Materiales y Métodos: Se llevó a cabo un estudio retrospectivo de presentación de casos. Se evaluó a 19 pacientes con diagnóstico de fractura de húmero distal compleja tratados con reducción abierta y fijación interna entre 2015 y 2021. Se realizó un control radiográfico periódico y se evaluó el resultado funcional mediante escalas internacionales, como DASH y MEPS. Luego se procedió a extrapolar las variables obtenidas utilizando un programa estadístico.
Resultados: Se logró la consolidación de todas las fracturas. Se empleó el abordaje de Alonso Llames en 7 pacientes (37%) y la osteotomía de olécranon en 12 casos (63%). El puntaje DASH promedio fue de 11,31, lo que determinó discapacidades leves. El puntaje MEPS obtenido fue excelente en un paciente (5,26%), bueno en 10 (52,6%), regular en 7 (36,84%) y pobre en 1 (5,26%).
Conclusiones: La reducción abierta y la fijación interna son eficaces para tratar las fracturas complejas de húmero distal, permiten lograr buenos resultados posquirúrgicos. En esta serie, el 57% de los pacientes obtuvo resultados excelentes o buenos. No se halló una diferencia estadísticamente significativa con respecto a la elección de un abordaje u otro
Parrhesía. El lugar del “decir veraz” en el juego democrático
Authors: Camargo Ricardo 
Published: August 2022

La parrhesía constituye una práctica de “decir veraz” que Michel Foucault investiga genealógicamente en sus últimos seminarios del Colegio de Francia, como una de las maneras originales de constitución de uno mismo en la cultura grecolatina antigua. En este trabajo, dicha noción de parrhesía es desplegada en toda su contemporaneidad política, afirmándose que constituye un complemento fundamental para la tesis agonísitica de la democracia, en especial la defendida por Chantal Mouffe. El “decir veraz” del parrhesiasta, al interpelar de manera radical el statu quo de la identidad colectiva constituida en el proceso de politización propio de la democracia radical, subvierte y transforma dicha identidad en un objeto permanente de disputa. Se recupera así el sentido del polemos propio de la práctica democrática.
Exploiting stock data: a survey of state of the art computational techniques aimed at producing beliefs regarding investment portfolios
Authors: Linares Vásquez Mario , Hernández Losada Diego Fernando , González Osorio Fabio 
Published: August 2022

Selecting an investment portfolio has inspired several models aimed at optimising the set of securities which an investor may select according to a number of specific decision criteria such as risk, expected return and planning horizon. The classical approach has been developed for supporting the two stages of portfolio selection and is supported by disciplines such as econometrics, technical analysis and corporative finance. However, with the emerging field of computational finance, new and interesting techniques have arisen in line with the need for the automatic processing of vast volumes of information. This paper surveys such new techniques which belong to the body of knowledge concerning computing and systems engineering, focusing on techniques particularly aimed at producing beliefs regarding investment portfolios.
Flexible linear programming with fuzzy constraints
Authors: López Ospina Héctor Andrés , Restrepo López Mauricio 
Published: August 2022

The present work shows the basic concepts underlying flexible linear programming or linear programming with fuzzy constraints. The literature often presents this methodology related to inequality constraints. This works deals with a methodology for box and equality constrains; it shows how this type of problem is similar to parametric optimisation. Two examples are given to show the advantage of using this methodology.
Using multinomial and imprecise probability for non-parametric modelling of rainfall in Manizales (Colombia)
Authors: Chivatá Cárdenas Ibsen 
Published: August 2022

This article presents a rainfall model constructed by applying non-parametric modelling and imprecise probabilities; these tools were used because there was not enough homogeneous information in the study area. The area’s hydro logical information regarding rainfall was scarce and existing hydrological time series were not uniform. A distributed extended rainfall model was constructed from so-called probability boxes (p-boxes), multinomial probability distribution and confidence intervals (a friendly algorithm was constructed for non-parametric modelling by combining the last two tools). This model confirmed the high level of uncertainty involved in local rainfall modelling. Uncertainty encompassed the whole range (domain) of probability values thereby showing the severe limitations on information, leading to the conclusion that a detailed estimation of probability would lead to significant error. Nevertheless, relevant information was extracted; it was estimated that maximum daily rainfall threshold (70 mm) would be surpassed at least once every three years and the magnitude of uncertainty affecting hydrological parameter estimation. This paper’s conclusions may be of interest to non-parametric modellers and decisions-makers as such modelling and imprecise probability represents an alternative for hydrological variable assessment and maybe an obligatory procedure in the future. Its potential lies in treating scarce information and represents a robust modelling strategy for non-seasonal stochastic modelling conditions.
The Jouyban-Acree model’s usefulness for estimating ibuprofen and naproxen solubility in some cosolvent mixtures
Authors: Vargas E. Edgar F. , Barbosa B. Helber J. , Martínez Fleming 
Published: August 2022

Estimating drug solubility in cosolvent mixtures has been an important pharmaceutical science research field at theoretical and practical levels for several decades. The validity of an adapted version of the Jouyban-Acree (J-A) model for predicting ibuprofen (IBP) and naproxen (NAP) solubility in propylene glycol + water cosolvent mixtures was thus evaluated. The usefulness of Yalkowsky and Roseman’s solubility log-linear equation was also evaluated for the same drugs in such cosolvent system. The solubility estimation was studied as a function of temperature and cosolvent composition. The J-A and Y-R models only require experimental equilibrium solubility values in pure solvents at all temperatures evaluated. Estimated solubility values obtained by using both semi-empiric models were similar but presented notable deviations regarding experimental values presented in the literature, especially for IBP. These results show that currently available theoretical strategies for estimating this property must be improved; they also demonstrate the importance of experimental determination of drug solubility according to temperature in all cosolvent mixtures which could be useful when designing homogeneous liquid dosage at industrial level.
Hierarchical production planning model in flexible job shop including a preemption and sequence-dependent setup times
Authors: Osorio Gómez Juan Carlos , Castrillón  Montenegro Oscar Eduardo , Toro Cardona Juliana Andrea , Orejuela Cabrera Juan Pablo 
Published: August 2022

Production planning and control are complex problems for manufacturing organisations. Hierarchical production planning and control is one way to address the problem as it can reduce its complexity and reach good solutions in reasonable computational time. This paper presents a hierarchical approach to resolving production programming in a flexible job shop configuration; this problem includes pre-emption and sequence-dependent setup times. Although non-optimal (as expected), good solutions were obtained as shown in the validation of the method.
Hydrodynamic ecohydraulic habitat assessment aimed at conserving and restoring fluvial hydrosystems
Authors: Diez Hernández Juan Manuel 
Published: August 2022

Fluvial conservation and restoration measures’ efficiency was evaluated in terms of ecological state enhancement, comparing future scenarios with historical or altered conditions. Ecohydraulics provides valuable scientific tools for the environmental diagnosis of lotic ecosystems, evaluating the combined effect of flow regime and channel structure on habitat quality for aquatic biota. This paper adopts an analytic-synthetic approach to the interdisciplinary challenge of fluvial ecohydraulics for computational fluid dynamics (CFD) within the framework of ecosystem water management. The procedure for multidimensional (2D/3D) evaluation of the physical aquatic habitat is described as well as its predictive ability and main applications. The 2D depth-averaged scheme is highlighted whose velocity simulation error (being normally lower than 10%) overcomes classic one-dimensional (1D) simplifications. The basic aspects of biological habitat modelling, abiotic variables and biological preference are summarised. Combining eco logical criteria with hydrodynamic flow patterns is illustrated for producing discrete habitat fields which were then spatially and temporarily integrated in ecohydraulic analysis.
Swarm intelligence: problem-solving societies (a review)
Authors: Muñoz Mario A. , López Jesús A. , Caicedo Eduardo F. 
Published: August 2022

This paper presents a review of the basic concepts of swarm intelligence and some views regarding the future of research in this area aimed at establishing a starting point for future work in different engineering fields. A bibliographic search of the most updated databases regarding classic articles on the subject and the most recent applications and results was used for constructing this review, especially in the areas of automatic control, signal and image processing and robotics. The main concepts were selected and organised in chronological order. A taxonomy was obtained for evolutionary computing techniques, a clear differentiation between swarm intelligence and other evolutionary algorithms and an overview of the different techniques and applications.
Pentachlorophenol reduction in raw Cauca river water through activated carbon adsorption in water purification
Authors: Torres Patricia , Cruz Vélez Camilo Hernán , González Magally , Gutiérrez Héctor Mario , Barba Luz Edith , Escobar Juan Carlos , Germán Delgado Luis 
Published: August 2022

Reducing chemical risk in raw water from the River Cauca (caused by the presence of pentachlorophenol and organic matter (real color, UV254 absorbance)) was evaluated at bench scale by using three treatment sequences: adsorption with powdered activated coal (PAC); adsorption – coagulation; and, adsorption – disinfection – coagulation. The results showed that although PAC is appropriate for pentachlorophenol removal, and its use together with the coagulant (aluminium sulphate) significantly improved phenolic compound and organic matter removal (promoting enhanced coagulation), the most efficient treatment sequence was adsorption – disinfection - coagulation, achieving minor pentachlorophenol levels than detection (1.56 μg/l) and WHO limits (9μg/l) due to the effect of chloride on PAC.
Non-uniform electric field-induced yeast cell electrokinetic behavior
Authors: Fernández Morales Flavio Humberto , Duarte Julio Enrique , Samitier Martí Joseph 
Published: August 2022

Common dielectrophoresis (c-DEP, i.e. neutral matter motion induced by non-uniform electric fields) has become a basic phenomenon of biochips intended for medical, biological and chemical assays, especially when they imply bioparticle handling. This paper deals with modelling and experimental verification of a castellated, c-DEP-based, microelectrode array intended to handle biological objects. The proposed microsystem was developed employing platinum electrodes patterned by lift-off, silicon micro machining and photoresin patterning techniques. Saccharomyces cerevisiae were used as test bioparticles for experimental verification. Yeast cells were repelled toward electrode bays and toward interelectrodic gaps tor frequencies around 20 MHz where there is minimum electric field strength, corresponding to a negative dielectrophoretic phenomenon. Yeast cell agglomerations were observed around electrode edges for frequencies of around 2 MHz where there is maximum electric field strength, thereby verifying the positive dielectrophoretic phenomenon. Bioparticles were separated from the electrode edges when the working frequency was reduced and they were dragged towards the electrode centre, remaining there while the frequency was low enough. Such atypical pattern may be explained due to the occurrence of positive dielectrophoresis overlap with electrohydrodynamic effects (i.e. the viscous drag force acting on the particles was greater than the dielectrophoretic force at frequencies where positive dielectrophoresis should occur). The experiments illustrated microsystem convenience in microhandling biological objects, the reby providing these microarrays’ possible use with other cells. Liquid motion resulting from electrohydrodynamic effects must also be taken into account when designing bioparticle micromanipulators, and could be used as a mechanism for cleaning electrode surfaces.
Mathematically modelling the power requirement for a vertical shaft mowing machine
Authors: Pérez de Corcho Fuentes Jorge Simón , Garbati Pegna Francesco 
Published: August 2022

This work describes a mathematical model for determining the power demand for a vertical shaft mowing machine, particularly taking into account the influence of speed on cutting power, which is different from that of other models of mowers. The influence of the apparatus’ rotation and translation speeds was simulated in determining power demand. The results showed that no changes in cutting power were produced by varying the knives’ angular speed (if translation speed was constant), while cutting power became increased if translation speed was increased. Variations in angular speed, however, influenced other parameters determining total power demand. Determining this vertical shaft mower’s cutting pattern led to obtaining good crop stubble quality at the mower’s lower rotation speed, hence reducing total energy requirements.
Comparing two spatio-temporal query languages: SQLST and Güting’s language
Authors: Pérez Montoya Luis Miguel , Moreno Arboleda Francisco Javier 
Published: August 2022

Spatio-temporal databases allow us to represent objects and phenomena from the real world which change position or shape as time elapses. Several query languages have been proposed during the last decade to deal with this type of database. Two of these languages have been compared in this paper: SQLST and Güting’s language. The comparison was based on criteria which have been applied to programming languages; however, they were adapted here to evaluate database query languages. The results led to concluding that both languages high degree of expressiveness may affect other criteria such as readability and simplicity, especially in the case of Güting’s language.
The characteristics of oxygen-enriched combustion and perspectives regarding its application in SMEs having high-temperature processes
Authors: González Palencia Juan Carlos , Amell Arrieta Andrés Adolfo , Cadavid Sierra Francisco Javier 
Published: August 2022

Small and medium-sized enterprises (SMEs) having high temperature processes, such as heat treating and melting, are socially and economically important for developing countries. Consequently, their competitiveness must thus be increased to guarantee their permanence in the market. As these companies are thermal energy intensive, their competitiveness is affected by obsolescence and the low efficiency of older combustion devices, thereby making research necessary and being open to and aware of new technologies. With this aim in mind, a review of the state of the art regarding oxygen-enhanced combustion (OEC) is presented, highlighting its productivity and environmental benefits. A brass melting process in a self-regenerative furnace is shown to account for its potential, in which 28%, 43% and 34% reductions in fuel consumption, process time and CO2 emissions were obtained, respectively, and a 30% increase in efficiency, by increasing the oxygen content in the oxidiser from 21% to 35%. However, increased O2 supply cost constitutes an obstacle to applying this technique in SMEs.
Antonio Cassarino's Latin translation of Plutarch's Bruta animalia ratione uti
Authors: Gaál Balázs 
Published: August 2022

Abstract
The present paper aims at giving a text edition of Antonio Cassarino's humanist Latin translation of Plutarch's dialogue Bruta animalia ratione uti. This is the earliest of three translations made of this dialogue in the course of the 15th century. The text itself is extant in three different manuscripts, one of which is a codex of the Vatican Library (Vat. lat. 3349), compiled after Cassarino's death by Panormita. A comparison of the text variants has led to several results. First, some of the errors shared by all three manuscripts show that they go back to a common archetype already at some distance from the translator's original copy. Second, Panormita relied heavily on a codex of the Biblioteca della Società Siciliana per la Storia Patria in Palermo (MS Lodi XII E 13) in preparing his own version. Third, the Vatican codex is far from being the best representative of Cassarino's original translation. Though Panormita corrected several of the common inherited errors, he made changes to the text without consulting the Greek. In almost every instance, it is a codex of the Biblioteca Casanatense of Rome (Bibl. Casan. 665 C II 8) which gives the best reading, providing the clue for a successful reconstruction of the text. An attempt will be made to trace the version contained in this codex back to a certain person named Balbi, referred to in the dedicatory letter as being a learned expert of both languages, Greek and Latin. Along with the establishment of the text, it will also be possible to define the original Greek source codex Cassarino used for his translation (Vat. Pal. gr. 170).