bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salp swarm algorithm based on golden section and adaptive and its application in target tracking
Authors: Guo Zhimin , Tian Yangyang , Feng Yuxing , Zhang Huanlong , Liu Junfeng , Wang Zanfeng 
Published: April 2022

AbstractIn order to solve the problem that the conventional tracker is not adapted to the abrupt motion, a tracking algorithm based on the improved salp swarm algorithm (ISSA) was proposed. Visual tracking is considered to be a process of locating the optimal position through the interaction between leaders and followers in successive images. Firstly, the adaptive mechanism of leader and follower is introduced into the original salp swarm algorithm (SSA) to balance the exploitation and exploration of the algorithm. This method can improve the accuracy and effect of tracking. Secondly, the golden‐sine algorithm was used to update the position of followers, considering that the SSA had a single spatial search mode for followers and was easy to fall into the local optimum. By comparing with 19 classical tracking algorithms, qualitative and quantitative analysis is carried out to verify the tracking effect of the proposed method. A large number of experimental results show that the algorithm proposed here has good performance in visual tracking, especially for mutation motion tracking.
Unmanned aerial vehicles object detection based on image haze removal under sea fog conditions
Authors: Pikun Wang , Ling Wu , Jiangxin Qi , Jiashuai Dai 
Published: April 2022

AbstractUnmanned aerial vehicles (UAVs) have gradually become a major air threat to ships because of small size, good maneuverability, and low cost. Vision‐based UAV detection offers one of the main ways to identify and protect against UAVs. Unlike land environment, the weather is complicated at sea. The visibility of an object is undermined by such factors as sea fog and sunlight, which makes it difficult to detect UAVs at sea through vision‐based object detection. For the purpose of object detection at sea, this paper proposes a UAV object detection method based on image haze removal. In the proposed method, an improved dark channel haze removal (DCHR) algorithm is utilized to remove haze for and restore video images. Additionally, co‐ordinate attention (CoordAttention, CA) is introduced to the lightweight algorithms of You Only Look Once (YOLO) for the object detection in restored video images, so as to improve the precision and speed of detection and reduce the miss rate. Some video images are also taken for detection experiments to verify the feasibility and effectiveness of the proposed method.
Sonographic differential diagnosis of duplex kidneys
Authors: Deeg Karl-Heinz 
Published: April 2022

AbstractDuplex kidneys have two renal pelvises and two ureters, which can join on the way to the urinary bladder but can also enter the bladder separately. A distinction must be made between normal and pathological duplex kidneys. In normal duplex kidneys, both renal pelvises are normal in width, and the upper and lower poles are approximately the same size. Furthermore, ureters are not dilated, and the upper and lower poles of the kidneys are not cystically altered. In contrast, pathological duplex kidneys, occurring in about 50 % of cases, are characterized by dilation of one or both renal pelvises. Additionally, one or both ureters may be dilated. Megaureters may be obstructive or refluxive. If a megaureter is present, a ureterocele must be ruled out, as well as an ectopically opening ureter. A pathological duplex kidney must always be assumed if one pole of the kidney is hypoplastic. Hypoplasia of the upper renal pole is often associated with an obstructive megaureter. Vesicoureteral reflux into the lower pyelon is common in hypoplasia of the lower pole. In the presence of vesicoureteral reflux, the associated (lower) pyelon is dilated when the bladder is full or during micturition. In addition, there is a dilated ureter. On the other hand, the pyelon can have a normal width when the bladder is empty. In rare cases, one pole may be cystically altered in pathological duplex kidneys. In this instance, segmental multicystic dysplastic duplex kidney must be differentiated from segmental multicystic nephroma.
Assessment of Cranial Radiotherapy Treatment in T-cell Lymphoblastic Lymphoma: Retrospective Study from Tertiary Care Center
Authors: Mehta Maitrik , Shah Isha , Parikh Ankita , Suryanarayan U. , Panchal Harsha , Singh Jayesh , T. Arun 
Published: April 2022

Abstract
Introduction Leukemia-like regimens given for acute lymphoblastic leukemia (ALL) are the cornerstone of treatment for T-cell lymphoblastic lymphoma (LBL) and can produce complete remission rates exceeding 90%. For central nervous system (CNS) prophylaxis, intrathecal chemotherapy and cranial irradiation are used to prevent future CNS recurrence.
Objective The purpose of this study was to assess CNS relapse rate after cranial prophylaxis treatment given at our institute.
Materials and Methods In this retrospective analysis, between July 2013 and June 2019, 149 files of lymphoblastic lymphoma were reviewed. Out of these, 53 patients received cranial irradiation. All patients were given CNS-directed therapy in the form of intrathecal methotrexate and patients with CNS-negative disease and primary tumor complete response or more than partial response after chemotherapy were given prophylactic cranial irradiation (18 Gy/10#), and in patients with upfront CNS involvement, therapeutic cranial irradiation (24 Gy/12#) was delivered. Radiotherapy was delivered as per the standard conventional protocol on a linear accelerator.
Results Out of 53 patients (age range: 2–50 years, mean–16.79 years, 26 [49.1%] pediatric [<14 years], 27 [50.9%] adults [>14 years]), 13/53 (24.5%), and 40/53 (75.5%) patients were on MCP 841 and BFM 90 protocols, respectively. Also, 48 (90.56%) patients received prophylactic cranial irradiation (25 [52.1%] pediatric, 23 [47.9%] adults). Moreover, 3/48 (6.25%) (2 [4.16%] pediatric, 1 [2.08%] adult) patients had CNS failure after receiving prophylactic cranial irradiation. For 48 target patients, with the median follow-up of 27.27 months (26.1 months–pediatric, 28.2 months– adults), EFS (event-free survival) in the brain was 93.8% (92%: pediatric, 95.7%: adults). Also, the difference between pediatric and adult groups was not statistically significant (p-value = 0.662). Five (9.43%) patients had CNS-positive disease upfront and received therapeutic cranial irradiation.
Conclusion In BFM 90/MCP 841 protocol in lymphoblastic lymphoma, prophylactic cranial irradiation and intrathecal methotrexate have been the standard of care as the CNS-directed therapy to prevent cranial infiltration. Though our results are not at par with the published world literature, further research and efforts are required to prevent CNS relapse in a selected sub-set of patients with lymphoblastic lymphoma.
Rubidium Uptake in Chest Tumors on PET/CT
Authors: Oldan Jorge D. , Femi-Abodunde Abiola D. , Muhleman Mitchel A. , Khandani Amir H. 
Published: April 2022

Abstract
Background Chest tumors are often found incidentally on cardiac scans; we aimed to describe the findings of rubidium (Rb) in incidentally discovered extracardiac tumors.
Materials and Methods We reviewed a database of cardiac Rb scans performed over a period of 11 years and identified those with a previously unsuspected malignancy seen on the plane of section. We then measured maximum standard uptake value for each of the tumors, as well as background lung, liver, mediastinum, and body wall. In cases where fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) was available, we compared Rb results with FDG PET/CT.
Results We identified 63 patients meeting criteria including full visualization of a tumor of at least 1.0 cm with no prior treatment. Of these patients, 17 had breast, 36 had lung, and 10 had miscellaneous other tumors. We selected patients with either breast or lung tumors for further analysis. Overall uptake was relatively stable between rest and stress but lower than FDG PET/CT; it was generally low and similar to blood pool. There was a small but statistically significant correlation between estrogen receptor positivity and Rb uptake in breast tumors. There was a stable pattern of uptake in background tissues, with liver being greater than mediastinal blood pool, which in turn was more avid than lung, which was more avid than subcutaneous body wall tissues. Lung showed a noticeable tendency toward increased uptake in dependent regions, likely reflecting low-level atelectasis.
Conclusion Uptake was stable between rest and stress but low relative to FDG PET/CT; some correlations with receptors suggest it may be useful in molecular imaging.
Unexpected Rare Association of Secondary Breast, Thyroid, and Ovarian Lymphomas in a Female Patient with Burkitt Lymphoma: PET-CT Findings
Authors: Ouriagli Salah Nabih 
Published: April 2022

AbstractWe report the case of a 15-year-old female, followed for Burkitt lymphoma with initial ovarian presentation. Positron emission tomography-computed tomography (PET-CT) with 18F-fluorodeoxyglucose (18F-FDG) performed to evaluate initial extension assessment showed an unexpected association with secondary breast, thyroid, and ovarian lymphomas. To our knowledge, this association is very rare, unusual, and these extranodal presentations have been reported in literature as a separate case report. Authors highlight performance of PET-CT with 18F-FDG to determinate the secondary origin of this multiglandular involvement, to establish a lesional map of the whole body, and to contribute to the therapeutic decision.
Detection of Spinal Tuberculosis by F-18 FDG PET/CT as a Cause of Unusual Referred Pain in the Right Upper Quadrant of Abdomen
Authors: Sampath Santhosh , Basumani Pandurangan , Kothandaraman Anand , Ramakrishnan Ravi 
Published: April 2022

AbstractTuberculous involvement of the spine (tuberculosis [TB] spine) can cause severe morbidity unless detected and treated early. Apart from the constitutional symptoms, it can present with back pain, kyphosis, gait abnormality, and paraplegia secondary to the bone or spinal cord involvement. There had been instances of TB spine presenting directly as abdominal pain due to psoas abscesses. Herein, we report a very rare clinical manifestation of TB spine as referred pain in the right upper abdominal quadrant due to right epidural phlegmon associated with T7 vertebra, detected by positron emission tomography.
‘The chances are zero’: a qualitative study on perceived susceptibility to pregnancy among women experiencing homelessness
Authors: Galvin Annalynn M. , Garg Ashvita , Griner Stacey B. , Diener Anelise K. , Thompson Erika L. 
Published: May 2022

Background Women experiencing homelessness are at higher risk of unintended pregnancy than women stably housed. The way women perceive their susceptibility to pregnancy may contribute to effective contraceptive use. This study aimed to explore how women experiencing homelessness perceive their susceptibility to pregnancy with and without contraception from a qualitative, emic perspective. Methods Semi-structured interviews (n = 19) were conducted from December 2019 to October 2020 among English-speaking, pregnancy-capable (i.e. not sterilised) women, aged 18–45 years, experiencing homelessness. Interview questions included perceived susceptibility to pregnancy with and without contraception, attitudes toward pregnancy, and pregnancy intention. Interviews were audio-transcribed and coded to consensus using a seven-step coding process. Themes were identified via thematic and framework analysis, stratifying participants by pregnancy desire in the next year: yes (n = 4), no (n = 9), or don’t know (n = 6). Results Seventeen women reported inconsistent or no contraceptive use. Some women found their risk of pregnancy was equal with and without contraception based on perceptions of specific contraception efficacy (e.g. condoms vs pills); fertility and fecundity concerns; and high abstinence self-efficacy themes. In stratified analysis, women who desired pregnancy or were uncertain of pregnancy desire in the next year reported similar perceived susceptibility with and without contraception, compared with women not desiring pregnancy in the next year. Conclusions Given the need to have higher susceptibility to pregnancy without contraceptive use for consistent contraception uptake, findings may explain the lack of contraceptive behaviours and contraception preferences related to pregnancy desire.
Physicochemical classification of organisms
Authors: Vallina Estrada Eloy , Oliveberg Mikael 
Published: May 2022

Significance
A common way to establish functional relations across organisms is through sequence conservation. In this study, we show that functional evolution also involves a second level of optimization coded in sequence regions that are generally considered nonconserved: the charge of the hypervariable surfaces of folded proteins. The physicochemical signatures of this protein-surface optimization not only diverge in a phylogenetically consistent way, but also are so systematically organized that they allow for detailed functional classification of organisms across all kingdoms of life. Accordingly, the finding 1) exposes a universal determinant of cellular fitness and 2) presents an alternative method for evolutionary and functional elucidation of organisms that is orthogonal to conventional sequence alignment.
A comparative approach reveals diversity of floral developmental processes in Urticaceae
Authors: Pedersoli Giseli D , Staedler Yannick M , Schönenberger Jürg , Teixeira Simone P 
Published: April 2022

Abstract
Most species of Urticaceae, the nettle family, have small and inconspicuous, diclinous flowers, in which the perianth, androecium and gynoecium tend to vary in number. Our objective was to study the morphology of the developing flowers of seven species of Urticaceae to understand the pathways that lead to the different patterns of floral reduction and the complex development of pseudomonomerous gynoecia. Buds and flowers were prepared for electron and light microscopy. Vascularization was studied via high resolution X-ray computed tomography micro-CT. Only one whorl of perianth organs is initiated, except for Phenax sonneratii, the flower of which is achlamydeous; variation in perianth merosity results from absence of organs from inception; dicliny results from the absence of stamens from inception (pistillate flowers) and from pistil abortion at intermediate developmental stages (staminate flowers). The gynoecium results from a primordium that divides partially forming two congenitally united primordia (most species) or from a single primordium that apparently does not divide. The gynoecium is served by a single (four species), or two vascular bundles. This second condition is expected for a pseudomonomerous gynoecium. Pistillode or rudimentary carpels occur in staminate flowers. The comparison among species shows that the developmental processes acting in the floral construction in Urticaceae is diverse.
Defining diagnostic trajectories in patients with podocytopathies
Authors: Cirillo Luigi , Lugli Gianmarco , Raglianti Valentina , Ravaglia Fiammetta , Buti Elisa , Landini Samuela , Becherucci Francesca 
Published: April 2022

ABSTRACT
Podocytopathies are glomerular disorders in which podocyte injury drives proteinuria and progressive kidney disease. They encompass a broad spectrum of aetiologies, resulting in pathological pictures of minimal-changes, focal segmental glomerulosclerosis, diffuse mesangial sclerosis or collapsing glomerulopathy. Despite improvement in classifying podocytopathies as a distinct group of disorders, the histological definition fails to capture the relevant biological heterogeneity underlying each case, manifesting as extensive variability in disease progression and response to therapies. Increasing evidence suggests that podocytopathies can result from a single causative factor or a combination of multiple genetic and/or environmental risk factors with different relative contributions, identifying complex physiopathological mechanisms. Consequently, the diagnosis can still be challenging. In recent years, significant advances in genetic, microscopy and biological techniques revolutionized our understanding of the molecular mechanisms underlying podocytopathies, pushing nephrologists to integrate innovative information with more conventional data obtained from kidney biopsy in the diagnostic workflow. In this review, we will summarize current approaches in the diagnosis of podocytopathies, focusing on strategies aimed at elucidating the aetiology underlying the histological picture. We will provide several examples of an integrative view of traditional concepts and new data in patients with suspected podocytopathies, along with a perspective on how a reclassification could help to improve not only diagnostic pathways and therapeutic strategies, but also the management of disease recurrence after kidney transplantation. In the future, the advantages of precision medicine will probably allow diagnostic trajectories to be increasingly focused, maximizing therapeutic results and long-term prognosis.
Single-Cell Identification, Drug Susceptibility Test, and Whole-genome Sequencing of Helicobacter pylori Directly from Gastric Biopsy by Clinical Antimicrobial Susceptibility Test Ramanometry
Authors: Liu Min , Zhu Pengfei , Zhang Lei , Gong Yanhai , Wang Chen , Sun Lu , Wang Lili , Chen Rongze , Mao Yuli , Fu Xiaoting , Zhang Lili , Xu Teng , Ji Yuetong , Dong Quanjiang , Ma Bo , Zhang Jianzhong , Xu Jian 
Published: April 2022

Abstract

Background
The battle against Helicobacter pylori (H. pylori) infections demands fast, reliable, and sensitive methods for pathogen identification (ID), antimicrobial susceptibility tests (ASTs) based on metabolic response, and genome-wide mutation profiling that reveals resistance mechanisms.

Methods
Here we introduce Clinical Antimicrobial Susceptibility Test Ramanometry for H. pylori (CAST-R-HP), and its validation with clinical samples. This method performs rapid ID, metabolism inhibition–based AST, and high-quality whole-genome sequencing for cells of targeted resistance phenotype, all at precisely 1-cell resolution and directly from biopsy samples.

Results
In CAST-R-HP, automated acquisition and machine learning of single-cell Raman spectra (SCRS) enable distinguishing individual H. pylori cells directly from a biopsy sample, with 98.5 ± 0.27% accuracy in ID. Moreover, by adding a 48- to72-h D2O feeding and drug exposure step prior to SCRS acquisition, CAST-R-HP reports AST for levofloxacin and clarithromycin with 100% accuracy, based on metabolic inhibition level. Furthermore, CAST-R-HP supports rapid sorting, low-bias DNA amplification, and full genome sequencing of single H. pylori cells with the SCRS defined, targeted drug-susceptibility phenotype, via Raman-activated gravity-driven cell encapsulation and sequencing. The genome-wide mutation map (maximum 99.70% coverage), at precisely 1-cell resolution, not only elucidates the drug-susceptibility phenotypes but also unveils their underlying molecular mechanisms.

Conclusion
The culture independency, shorter turnaround time, high resolution, and comprehensive information output suggest that CAST-R-HP is a powerful tool for diagnosing and treating H. pylori infections.
The potential for bacteria from carbon-limited deep terrestrial environments to participate in chlorine cycling
Authors: Bhattarai Susma , Temme Hanna , Jain Abhiney , Badalamenti Jonathan P , Gralnick Jeffrey A , Novak Paige J 
Published: April 2022

Abstract
Bacteria capable of dehalogenation via reductive or hydrolytic pathways are ubiquitous. Little is known, however, about the prevalence of bacterial dechlorination in deep terrestrial environments with a limited carbon supply. In this study we analyzed published genomes from three deep terrestrial subsurface sites: a deep aquifer in Western Siberia, the Sanford Underground Research Facility in South Dakota, USA, and the Soudan Underground Iron Mine (SUIM) in Minnesota, USA to determine if there was evidence to suggest that microbial dehalogenation was possible in these environments. Diverse dehalogenase genes were present in all analyzed metagenomes, with reductive dehalogenase and haloalkane dehalogenase genes the most common. Taxonomic analysis of both hydrolytic and reductive dehalogenase genes was performed to explore their affiliation; this analysis indicated that at the SUIM site, hydrolytic dehalogenase genes were taxonomically affiliated with Marinobacter species. Because of this affiliation, experiments were also performed with Marinobacter subterrani strain JG233 (‘JG233’), an organism containing three predicted hydrolytic dehalogenase genes and isolated from the SUIM site, to determine whether hydrolytic dehalogenation was an active process and involved in growth on a chlorocarboxylic acid. Presence of these genes in genome appears to be functional, as JG233 was capable of chloroacetate dechlorination with simultaneous chloride release. Stable isotope experiments combined with confocal Raman microspectroscopy demonstrated that JG233 incorporated carbon from 13C-chloroacetate into its biomass. These experiments suggest that organisms present in these extreme and often low-carbon environments are capable of reductive and hydrolytic dechlorination and, based on laboratory experiments, may use this capability as a competitive advantage by utilizing chlorinated organic compounds for growth, either directly or after dechlorination.
Coronary artery bypass grafting for coronary artery anomalies in infants and young children
Authors: Hohri Yu , Yamagishi Masaaki , Maeda Yoshinobu , Asada Satoshi , Hongu Hisayuki , Numata Satoshi , Yaku Hitoshi 
Published: April 2022

Abstract

OBJECTIVES
Coronary artery bypass grafting (CABG) has been reported for coronary artery diseases in patients with Kawasaki disease and coronary artery complications after arterial switch operations for transposition of the great arteries. However, only a few studies have explored this modality for congenital coronary artery anomalies. As congenital coronary artery anomalies, particularly left coronary artery atresia and stenosis, are one of the reasons for sudden death, coronary revascularization is often required in infants and young children. Therefore, we aimed to investigate the outcome of CABG for such anomalies in infants and young children.

METHODS
From 2014 to 2018, 3 infants and 2 children (median age: 10 months; range: 6–40 months) with coronary artery anomalies underwent CABG at our hospital. The indications for the procedure included left main coronary artery atresia and stenosis in 2 and 3 patients, respectively. Graft patency was evaluated postoperatively by contrast-enhanced computed tomography or coronary angiography, and postoperative outcomes (including death and cardiac events) were assessed during the follow-up period.

RESULTS
No 30-day or in-hospital mortalities were noted. Postoperative examinations revealed patent grafts in all patients. They were discharged without any cardiac complications. Regarding the outcomes at the follow-up period, the graft patency rate was 80.0% (4/5 grafts), with no deaths or cardiac events.

CONCLUSIONS
CABG is a useful strategy for coronary revascularization in infants and young children with coronary artery anomalies. Although the mid-term outcomes and patency are satisfactory, careful follow-up is necessary because the long-term outcomes remain unknown.