bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice
Authors: Li Ting , Lu Dingyi , Yao Chengcheng , Li Tingting , Dong Hua , Li Zhan , Xu Guang , Chen Jiayi , Zhang Hao , Yi Xiaoyu , Zhu Haizhen , Liu Guangqin , Wen Kaiqing , Zhao Haixin , Gao Jun , Zhang Yakun , Han Qiuying , Li Teng , Zhang Weina , Zhao Jie , Li Tao , Bai Zhaofang , Song Moshi , He Xinhua , Zhou Tao , Xia Qing , Li Ailing , Pan Xin 
Published: February 2022

AbstractKoolen-de Vries syndrome (KdVS) is a rare disorder caused by haploinsufficiency of KAT8 regulatory NSL complex subunit 1 (KANSL1), which is characterized by intellectual disability, heart failure, hypotonia, and congenital malformations. To date, no effective treatment has been found for KdVS, largely due to its unknown pathogenesis. Using siRNA screening, we identified KANSL1 as an essential gene for autophagy. Mechanistic study shows that KANSL1 modulates autophagosome-lysosome fusion for cargo degradation via transcriptional regulation of autophagosomal gene, STX17. Kansl1+/− mice exhibit impairment in the autophagic clearance of damaged mitochondria and accumulation of reactive oxygen species, thereby resulting in defective neuronal and cardiac functions. Moreover, we discovered that the FDA-approved drug 13-cis retinoic acid can reverse these mitophagic defects and neurobehavioral abnormalities in Kansl1+/− mice by promoting autophagosome-lysosome fusion. Hence, these findings demonstrate a critical role for KANSL1 in autophagy and indicate a potentially viable therapeutic strategy for KdVS.
Superresolution concentration measurement realized by sub-shot-noise absorption spectroscopy
Authors: Matsuzaki Korenobu , Tahara Tahei 
Published: February 2022

AbstractAbsorption spectroscopy is one of the most widely used spectroscopic methods. The signal-to-noise ratio in conventional absorption spectroscopy is ultimately limited by the shot noise, which arises from the statistical property of the light used for the measurement. Here we show that the noise in absorption spectra can be suppressed below the shot-noise limit when entangled photon pairs are used for the light source. By combining broadband entangled photon pairs and multichannel detection, we realize the acquisition of sub-shot-noise absorption spectra in the entire visible wavelength. Furthermore, we demonstrate the strength of sub-shot-noise absorption spectroscopy for the identification and quantification of chemical species, which are two primary aims of absorption spectroscopy. For highly diluted binary mixture solutions, sub-shot-noise absorption spectroscopy enables us to determine the concentration of each chemical species with precision beyond the limit of conventional absorption spectroscopy. That is, sub-shot-noise absorption spectroscopy achieves superresolution in concentration measurements.
Unexpectedly minor nitrous oxide emissions from fluvial networks draining permafrost catchments of the East Qinghai-Tibet Plateau
Authors: Zhang Liwei , Zhang Sibo , Xia Xinghui , Battin Tom J. , Liu Shaoda , Wang Qingrui , Liu Ran , Yang Zhifeng , Ni Jinren , Stanley Emily H. 
Published: February 2022

AbstractStreams and rivers emit substantial amounts of nitrous oxide (N2O) and are therefore an essential component of global nitrogen (N) cycle. Permafrost soils store a large reservoir of dormant N that, upon thawing, can enter fluvial networks and partly degrade to N2O, yet the role of waterborne release of N2O in permafrost regions is unclear. Here we report N2O concentrations and fluxes during different seasons between 2016 and 2018 in four watersheds on the East Qinghai-Tibet Plateau. Thawing permafrost soils are known to emit N2O at a high rate, but permafrost rivers draining the East Qinghai-Tibet Plateau behave as unexpectedly minor sources of atmospheric N2O. Such low N2O fluxes are associated with low riverine dissolved inorganic N (DIN) after terrestrial plant uptake, unfavorable conditions for N2O generation via denitrification, and low N2O yield due to a small ratio of nitrite reductase: nitrous oxide reductase in these rivers. We estimate fluvial N2O emissions of 0.432 − 0.463 Gg N2O-N yr−1 from permafrost landscapes on the entire Qinghai-Tibet Plateau, which is marginal (~0.15%) given their areal contribution to global streams and rivers (0.7%). However, we suggest that these permafrost-affected rivers can shift from minor sources to strong emitters in the warmer future, likely giving rise to the permafrost non-carbon feedback that intensifies warming.
A review of the recent progress in battery informatics
Authors: Ling Chen 
Published: February 2022

AbstractBatteries are of paramount importance for the energy storage, consumption, and transportation in the current and future society. Recently machine learning (ML) has demonstrated success for improving lithium-ion technologies and beyond. This in-depth review aims to provide state-of-art achievements in the interdisciplinary field of ML and battery research and engineering, the battery informatics. We highlight a crucial hurdle in battery informatics, the availability of battery data, and explain the mitigation of the data scarcity challenge with a detailed review of recent achievements. This review is concluded with a perspective in this new but exciting field.
African fermented foods: overview, emerging benefits, and novel approaches to microbiome profiling
Authors: Obafemi Yemisi D. , Oranusi Solomon U. , Ajanaku Kolawole O. , Akinduti Paul A. , Leech John , Cotter Paul D. 
Published: February 2022

AbstractTraditional fermented foods are of major importance with respect to the socio-economic growth, food security, nutrition, and health of African consumers. In several African countries, traditional fermentation processes provide a means of food preservation, improving the shelf life and adding to the nutrients in the food products. As with any fermented foods, the associated food microbiota is of great importance and interest. Recent studies on the microbiome of African fermented foods using high-throughput DNA sequencing techniques have revealed the presence of diverse microbial populations of fundamental, technological, and commercial interest that could be harnessed to further improve health, food safety, and quality. This review provides an overview of African fermented foods, their microbiota, and the health-promoting potential of these foods and microbes.
Comparing the thermal stability of 10-carboxy-, 10-methyl-, and 10-catechyl-pyranocyanidin-3-glucosides and their precursor, cyanidin-3-glucoside
Authors: Voss Danielle M. , Miyagusuku-Cruzado Gonzalo , Giusti M. Mónica 
Published: February 2022

AbstractPyranoanthocyanins are vibrant, naturally derived pigments formed by the reaction of an anthocyanin with a cofactor containing a partially negatively charged carbon. This study compared the thermal stability and degradation products of 10-carboxy-pyranocyanidin-3-glucoside (pyruvic acid cofactor), 10-methyl-pyranocyanidin-3-glucoside (acetone cofactor), and 10-catechyl-pyranocyanidin-3-glucoside (caffeic acid cofactor) with their anthocyanin precursor to evaluate the role of the pyranoanthocyanin C10 substitution on stability. Pyranoanthocyanins exhibited absorbance half-lives ~2.1–8.6 times greater than cyanidin-3-glucoside, with ~15–52% of their original pigment remaining after 12 h of 90 °C heating at pH 3.0. 10-Methyl-pyranocyanidin-3-glucoside was the most stable (p < 0.01) based on UHPLC-PDA analysis, while 10-catechyl-pyranocyanidin-3-glucoside had the most stable color in part due to contribution from a colored degradation compound. Protocatechuic acid formed in all heated samples, which suggested a similar degradation mechanism among pigments. In conclusion, the C10 substitution impacted the extent of pyranoanthocyanin stability and the degradation compounds formed.
Perceiving societal pressure to be happy is linked to poor well-being, especially in happy nations
Authors: Dejonckheere Egon , Rhee Joshua J. , Baguma Peter K. , Barry Oumar , Becker Maja , Bilewicz Michał , Castelain Thomas , Costantini Giulio , Dimdins Girts , Espinosa Agustín , Finchilescu Gillian , Friese Malte , Gastardo-Conaco Maria Cecilia , Gómez Angel , González Roberto , Goto Nobuhiko , Halama Peter , Hurtado-Parrado Camilo , Jiga-Boy Gabriela M. , Karl Johannes A. , Novak Lindsay , Ausmees Liisi , Loughnan Steve , Mastor Khairul A. , McLatchie Neil , Onyishi Ike E. , Rizwan Muhammad , Schaller Mark , Serafimovska Eleonora , Suh Eunkook M. , Swann William B. , Tong Eddie M. W. , Torres Ana , Turner Rhiannon N. , Vinogradov Alexander , Wang Zhechen , Yeung Victoria Wai-lan , Amiot Catherine E. , Boonyasiriwat Watcharaporn , Peker Müjde , Van Lange Paul A. M. , Vauclair Christin-Melanie , Kuppens Peter , Bastian Brock 
Published: February 2022

AbstractHappiness is a valuable experience, and societies want their citizens to be happy. Although this societal commitment seems laudable, overly emphasizing positivity (versus negativity) may create an unattainable emotion norm that ironically compromises individual well-being. In this multi-national study (40 countries; 7443 participants), we investigate how societal pressure to be happy and not sad predicts emotional, cognitive and clinical indicators of well-being around the world, and examine how these relations differ as a function of countries’ national happiness levels (collected from the World Happiness Report). Although detrimental well-being associations manifest for an average country, the strength of these relations varies across countries. People’s felt societal pressure to be happy and not sad is particularly linked to poor well-being in countries with a higher World Happiness Index. Although the cross-sectional nature of our work prohibits causal conclusions, our findings highlight the correlational link between social emotion valuation and individual well-being, and suggest that high national happiness levels may have downsides for some.
Optimisation of self-healing of bio-foamed concrete bricks pores using Bacillus tequilensis under different temperature and CO2 curing conditions
Authors: Alshalif Abdullah F. , Juki M. Irwan , Tajarudin Husnul Azan , Othman N. , Al-Gheethi Adel Ali , Shamsudin S. , Altowayti Wahid , Sabah Saddam Abo 
Published: February 2022

AbstractThe self-healing of bio-concrete cracks and pores have been utilised worldwide to improve the properties of bio-concrete using different types of bacteria. Meanwhile, no published research was conducted to heal bio-foamed concrete bricks (B-FCB) pores using Bacillus tequilensis. Previous studies focused on the concentration of bacteria and neglect other factors that could affect the healing process. This research aimed to optimise the healing ratio of B-FCB pores using four factors: B. tequilensis concentration, concrete density, temperature and CO2 concentration. Initial water absorption (IWA) and water absorption (WA) were used as responses in statistical methods, namely, factorial and response surface methodology (RSM). B. tequilensis species was isolated from cement kiln dust, produced in a powder form, then subjected to simulate test using a special medium consisting of foamed concrete materials to check the survival ability in B-FCB. SEM, EDX, and XRD were used to investigate the healing process of B-FCB pores. The results revealed that the decrement ratios of IWA and WA of B-FCB were 52.8% and 29.1% compared to FCB, respectively. SEM results reflect the healing that occurred in B-FCB pores, mostly healed via precipitation of CaCO3 as demonstrated on the XRD results.
Structural properties of Bi thin film grown on Si (111) by quasi-van der Waals epitaxy
Authors: Chou Chieh , Wu Bo-Xun , Lin Hao-Hsiung 
Published: February 2022

AbstractCrystallinity of an 80-nm-thick bismuth thin film grown on Si (111) substrate by MBE was investigated. The highly (0003) textured Bi film contains two twinning domains with different bilayer stacking sequences. The basic lattice parameters c and a as well as b, the bilayer thickness, of the two domains were determined from a series of X-ray diffraction (XRD) measurements, and found that the differences are within 0.1% as compared with those of bulk Bi reported in literature, suggesting that the Bi film has been nearly fully relaxed. From the XRD φ-scans of asymmetric Bi (01–14), (10–15), (11–26) planes and Si (220) plane as well as selected area electron diffraction patterns and electron back scatter diffraction pole figures, we confirmed the well registration between the lattices of Si and Bi lattice, i.e. the ω angle difference between Bi[0003] and Si[111] and the φ angle difference between Bi[01–14] and Si[220] are 0.056° and 0.25°, respectively, and thus concluded that the growth is a quasi-van der Waals epitaxy.
Impact of local and systemic antimicrobials on leukocyte- and platelet rich fibrin: an in vitro study
Authors: Siawasch S. A. M. , Andrade C. , Castro A. B. , Teughels W. , Temmerman A. , Quirynen M. 
Published: February 2022

AbstractThe aim of this study was to evaluate the effect of local and systemic administration of antimicrobials to leukocyte- and platelet-rich fibrin (L-PRF). For part A, 16 tubes of venous blood were collected from each of eight systemically healthy subjects. Prior to blood centrifugation, 12 of the 16 tubes were injected with 0.125 ml, 0.25 ml or 0.50 ml metronidazole solution. One set of L-PRF membranes was used to assess the release of vascular endothelial growth factor AB, platelet-derived growth factor, transforming growth factor beta 1, and bone morphogenetic protein 2 at indicated time points. The metronidazole release over time by L-PRF membranes was also evaluated. The remaining L-PRF membranes were placed on the surface of agar plates inoculated with three different periodontal pathogens to determine their antibacterial activity. For part B, another six subjects were enrolled with three subjects taking 2 g amoxicillin and three subjects 500 mg metronidazole as prophylaxis prior to a periodontal treatment. Before and 2 h after consuming one of the prescribed antimicrobials, three tubes of blood were collected for preparing L-PRF membranes. These membranes were used to measure the antibacterial activity against periodontal pathogens. No statistically significant difference could be found in the release of growth factors between L-PRF membranes with and without incorporation of metronidazole solution. The release of metronidazole could be detected up to day 3, however with the highest concentration during the first 4 h. This concentration was dose dependent. The antibacterial capacity of L-PRF membranes increased significantly for both the systemic intake, and after the addition of metronidazole solution to the blood tubes before centrifugation, the latter again dose dependent. The antibacterial capacity of L-PRF against the periodontal pathogens tested can significantly be enhanced by the addition of antimicrobials, without disadvantage for the release of growth factors.
Catchment memory explains hydrological drought forecast performance
Authors: Sutanto Samuel Jonson , Van Lanen Henny A. J. 
Published: February 2022

AbstractHydrological drought forecasts outperform meteorological ones, which is anticipated coming from catchment memory. Yet, the importance of catchment memory in explaining hydrological drought forecast performance has not been studied. Here, we use the Baseflow Index (BFI) and the groundwater Recession Coefficient (gRC), which through the streamflow, give information on the catchment memory. Performance of streamflow drought forecasts was evaluated using the Brier Score (BS) for rivers across Europe. We found that BS is negatively correlated with BFI, meaning that rivers with high BFI (large memory) yield better drought prediction (low BS). A significant positive correlation between gRC and BS demonstrates that catchments slowly releasing groundwater to streams (low gRC), i.e. large memory, generates higher drought forecast performance. The higher performance of hydrological drought forecasts in catchments with relatively large memory (high BFI and low gRC) implies that Drought Early Warning Systems have more potential to be implemented there and will appear to be more useful.
Distance-based clustering using QUBO formulations
Authors: Matsumoto Nasa , Hamakawa Yohei , Tatsumura Kosuke , Kudo Kazue 
Published: February 2022

AbstractIn computer science, clustering is a technique for grouping data. Ising machines can solve distance-based clustering problems described by quadratic unconstrained binary optimization (QUBO) formulations. A typical simple method using an Ising machine makes each cluster size equal and is not suitable for clustering unevenly distributed data. We propose a new clustering method that provides better performance than the simple method, especially for unevenly distributed data. The proposed method is a hybrid algorithm including an iterative process that comprises solving a discrete optimization problem with an Ising machine and calculating parameters with a general-purpose computer. To minimize the communication overhead between the Ising machine and the general-purpose computer, we employed a low-latency Ising machine implementing the simulated bifurcation algorithm with a field-programmable gate array attached to a local server. The proposed method results in clustering 200 unevenly distributed data points with a clustering score 18% higher than that of the simple method. The discrete optimization with 2000 variables is performed 100 times per iteration, and the overhead time is reduced to approximately 20% of the total execution time. These results suggest that hybrid algorithms using Ising machines can efficiently solve practical optimization problems.
The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy
Authors: Kathrani Aarti , Yen Sandi , Swann Jonathan R. , Hall Edward J. 
Published: February 2022

AbstractThe effect of a hydrolyzed protein diet on the fecal microbiota has not been studied in feline chronic enteropathy (CE). Our study aimed to (1) compare the fecal microbiota of cats with CE to control cats with no gastrointestinal signs and (2) determine the effect of a hydrolyzed protein diet on the fecal microbiota of cats with CE and whether this differs between dietary responders and non-responders. The fecal microbiome of cats with CE (n = 36) showed decreased α-diversity in terms of genus richness (P = 0.04) and increased β-diversity in terms of Bray–Curtis Dissimilarity (P < 0.001) compared to control cats (n = 14).Clostridiumwas the only genera significantly over-represented in cats with CE compared to control cats (adjustedP < 0.1). After 6-weeks of feeding the diet, fifteen cats were classified as responders and 18 as non-responders, based on clinical signs. At the genus level, α-diversity was increased in non-responders versus responders at diagnosis, but decreased after dietary intervention in both groups (P < 0.05). At the family level, non-responders became increasingly dissimilar after dietary intervention (P = 0.012). In general, the abundance of bacteria decreased with feeding a hydrolyzed diet, with the genera most significantly affected being more frequently observed in non-responders.Bifidobacteriumwas the only genus that increased significantly in abundance post-diet and this effect was observed in both responders and non-responders. BothOscillibacterandDesulfovibrionaceae_unclassifiedwere most abundant in non-responders at diagnosis but were rarely observed post diet in neither responders nor non-responders. Cats with CE had similar microbiota changes to those described in human inflammatory bowel disease. Whether the presence ofOscillibacterandDesulfovibrionaceae_unclassifiedare indicators of non-response to the diet at diagnosis requires further investigation. Despite the hydrolyzed diet reducing α-diversity in all cats with CE, this did not resolve gastrointestinal signs in some cats. However, responders metabolized the diet in a similar manner, reflected by sustained β-diversity, while the microbiome of non-responders became increasingly dissimilar compared to diagnosis at the family level. Therefore, the microbiome may not be as tightly regulated in cats with CE that are non-responders and therefore, these cats would require additional therapy for remission of clinical signs.
Constant output characteristics and design methodology of double side LC compensated capacitive power transfer
Authors: Xiong Qiao , Shao Ying , Sun Pan , Sun Jun , Rong Enguo , Liang Yan 
Published: February 2022

AbstractCapacitive power transfer (CPT) has been verified to be capable of transferring a power level as high as inductive power transfer (IPT) recently, and has its own merits. It is a well complement of IPT in near-field wireless power transfer (WPT). This paper gives a newly designed method of realizing both constant output voltage (COV) and constant output current (COC) modes of double side LC compensated CPT. Firstly, through analysis of basic circuit characteristics, the conditions for both of the two modes are deduced theoretically. Especially, one merit of the method is that the conditions indicate a very clear relationship between the compensation components forming resonant tanks. Another merit is that the couple capacitors also participate in resonant tanks. Different from the COV mode, the COC mode can theoretically reach zero phase angle condition simultaneously. Based on these conditions, the parameter design methodology is proposed. Besides, an efficient model of double side LC compensated CPT is built, and the optimum load is calculated theoretically to guide the design course. Finally, the results of both simulations and experiments demonstrate high consistency with the theoretical analysis.
Body composition, physical fitness and cardiovascular risk factors in 9-year-old children
Authors: Henriksson Pontus , Sandborg Johanna , Henström Maria , Delisle Nyström Christine , Ek Evelina , Ortega Francisco B. , Löf Marie 
Published: February 2022

AbstractThe independent associations of body composition and physical fitness components with cardiovascular disease (CVD) risk factors in childhood are not fully understood. Thus, this cross-sectional study examined the independent associations of body composition and physical fitness with CVD risk factors in Swedish 9-year-old children (n = 411). Unadjusted linear regression analyses showed that body mass index (BMI), % fat mass and fat mass index were all positively associated with systolic and diastolic blood pressure, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Metabolic Syndrome (MetS) score (all β ≥ 0.229,P ≤ 0.001). These associations were virtually unaffected by adjustments for basic covariates (child’s age and sex, maternal educational level and maternal BMI), fat-free mass and physical fitness. Fat-free mass index had generally weak associations with CVD risk factors and no associations were statistically significant after adjustments (allP > 0.27). Greater cardiorespiratory fitness and motor fitness were associated with lower HOMA-IR and MetS score in unadjusted models (all β ≤ − 0.158,P ≤ 0.039) but not after adjustments for basic covariates and body composition. These findings indicate that cardiovascular health promotion in childhood may focus on the maintenance of a healthy fat mass.