bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Authors: Taylor Hugh , Li Howard J , Carson Sandra , Flores Valerie , Pal Lubna , Robbins Jared , Santoro Nanette F , Segars James H , Seifer David , Huang Hao , Young Steven , Zhang Heping 
Published: June 2022

IntroductionInfertility is a common complication of endometriosis. While in vitro fertilisation-embryo transfer (IVF) successfully treats endometriosis-associated infertility, there is some evidence that pregnancy rates may be diminished in women seeing fertility treatment for endometriosis-associated infertility compared with other etiologies of infertility. The use of gonadotropin releasing hormone (GnRH) agonist prior to IVF has been suggested to improve success, however studies have been small and rarely reported live birth rates. Recent approval of an oral GnRH antagonist for endometriosis provides a novel option for women with endometriosis who are undergoing IVF. There have been no studies on the efficacy of GnRH antagonists for the treatment of endometriosis-related infertility.Methods and analysisThis study is a multicentre, prospective, randomised, double-blind, placebo-controlled trial to study the efficacy of GnRH antagonist pretreatment for women with endometriosis who are undergoing IVF. A total of 814 patients with endometriosis undergoing fertility treatment will be enrolled and randomised 1:1 into two groups: elagolix 200 mg two times per day or placebo for 8 weeks, prior to undergoing IVF. All participants will then undergo IVF treatment per local protocols. The primary outcome is live birth. Secondary outcomes include oocyte number, fertilisation rate, embryo morphology and implantation rates, as well as rates of known endometriosis-related obstetrical outcomes (pregnancy-induced hypertension, antepartum haemorrhage, caesarean delivery and preterm birth).Ethics and disseminationThe PREGnant trial was approved by the Institutional Review Board at Johns Hopkins University. Results will be published in a peer-reviewed journal.Trial registration numberNCT04173169.
Interventions to improve media coverage of medical research: a codesigned feasibility and acceptability study with Australian journalists
Authors: Copp Tessa , Dakin Thomas , Nickel Brooke , Albarqouni Loai , Mannix Liam , McCaffery Kirsten J , Barratt Alexandra , Moynihan Ray 
Published: June 2022

ObjectivesAlthough the media can influence public perceptions and utilisation of healthcare, journalists generally receive no routine training in interpreting and reporting on medical research. Given growing evidence about the problems of medical overuse, the need for quality media reporting has become a greater priority. This study aimed to codesign and assess the feasibility of a multicomponent training intervention for journalists in Australia.DesignA small pragmatic feasibility study using a pre- and postdesign.Setting90 min online workshop.ParticipantsEight journalists currently working in Australia, recruited through the study’s journalist advisor and existing contacts of the researchers.InterventionThe training intervention covered a range of topics, including study designs, conflicts of interest, misleading medical statistics, population screening and overdiagnosis. The intervention also provided tools to help journalists with reporting, including a Tip Sheet and list of expert contacts in health and medicine. Preworkshop and postworkshop questionnaires were administered via Qualtrics.MeasuresAcceptability and feasibility of the intervention, and journalists’ knowledge of overdiagnosis and common issues with health stories. Quantitative results were analysed descriptively using SPSS. Qualitative data were thematically analysed.ResultsAll participants completed preworkshop and postworkshop questionnaires, and 6 completed the 6-week follow-up (75% retention). Feasibility findings suggest the intervention is acceptable and relevant to journalists, with participants indicating the workshop increased confidence with reporting on medical research. We observed increases in knowledge preworkshop to postworkshop for all knowledge measures on overdiagnosis and common issues with media coverage of medicine. Analysis of free-text responses identified several areas for improvement, such as including more examples to aid understanding of the counterintuitive topic of overdiagnosis and more time for discussion.ConclusionsPiloting suggested the multicomponent training intervention is acceptable to journalists and provided important feedback and insights to inform a future trial of the intervention’s impact on media coverage of medicine.
Players’, parents’ and staffs’ perceptions of injury prevention exercise programmes in youth rugby union
Authors: Sly Nicole , Soomro Mariam , Withall Adrienne L , Cullen Patricia , Turner Robin M , Flahive Sharron R 
Published: June 2022

Background and aimDespite evidence of their efficacy, there is no widespread adoption of injury prevention exercise programmes (IPEPs) among young players and coaches in community rugby union. The purpose of this study was to (1) analyse the knowledge and perceptions of injury prevention and IPEPs among staff, parents and players in youth rugby union and (2) explore the facilitators and barriers to implementation of IPEPs. With this contextual information, tailored implementation strategies can be created.MethodsParticipants completed an online survey addressing knowledge and perceptions of injury risk, injury prevention practices and a rugby-specific IPEP. Community rugby union players aged 14–18 years, their parents and staff were invited to participate, including school-based and development squads competing at a national level.ResultsSurveys were completed by 18 staff members, 72 parents and 56 players. Staff, parents and players believe that the risk of injury in youth rugby union is high and that injury prevention is important. The perceived role in injury prevention and availability of allied health staff, particularly strength and conditioning coaches, was apparent in this sample. Reported barriers to completion of IPEPs related to time, resources, awareness of the programme and end-users' attitudes or motivations. Leadership, the use of role models and the structure and routine provided by an IPEP were considered facilitative.ConclusionsThese findings inform future implementation strategies for IPEPs in this setting, including the need to provide practical solutions, education and considering the role of allied health staff in facilitating such programmes.
Percutaneous auricular nerve stimulation (neuromodulation) for the treatment of pain following outpatient surgery: a proof-of-concept case series
Authors: Ilfeld Brian M , Finneran John J , Dalstrom David , Wallace Anne M , Abdullah Baharin , Said Engy T 
Published: June 2022

BackgroundFollowing outpatient surgery, it is often difficult to provide adequate analgesia while concurrently minimizing opioid requirements. Ultrasound-guided percutaneous peripheral nerve stimulation has been proposed as an analgesic, but requires physician-level skills, advanced equipment, up to an hour to administer, and is frequently cost prohibitive. In contrast, percutaneous auricular neuromodulation may be placed by nursing staff in a few minutes without additional equipment, theoretically provides analgesia for nearly any anatomic location, lacks systemic side effects, and has no significant risks. We now present a case report to demonstrate proof of concept for the off-label use of an auricular neuromodulation device—originally developed to treat symptoms associated with opioid withdrawal—to instead provide analgesia following outpatient surgery.Case presentationFollowing moderately painful ambulatory orthopedic and breast surgery, seven patients had an auricular neuromodulation device (NSS-2 Bridge, Masimo, Irvine, California, USA) affixed within the recovery room in approximately 5 min and discharged home. Average resting and dynamic pain scores measured on the 0–10 Numeric Rating Scale were a median of 1 over the first 2 days, subsequently falling to 0. Five patients avoided opioid use entirely, while the remaining two each consumed 5 mg of oxycodone during the first 1–2 postoperative days. After 5 days, the devices were removed at home and discarded.ConclusionsThese cases demonstrate that ambulatory percutaneous auricular neuromodulation is feasible and may be an effective analgesic and decreasing or even negating opioid requirements following outpatient surgery. Considering the lack of systemic side effects, serious adverse events, and misuse/dependence/diversion potential, further study with a randomized, controlled trial appears warranted.
Cosmographic analysis of a closed bouncing universe with the varying cosmological constant in f(R, T) gravity
Authors: Bhardwaj Vinod Kumar , Pradhan Anirudh , Ahmed Nasr , Shaker A.A. 
Published: June 2022

Modelling of matter bounce in f( R, T) gravity has been presented with no violation of the null energy condition. Only a closed universe with negative pressure is allowed in good agreement with some recent observations that favour a universe with positive curvature. Our results agree with some recent works in which a combination of positive curvature and vacuum energy leads to non-singular bounces with no violation of the null energy condition. The stability of the model has been discussed. The cosmographic parameters are developed for the derived model to explain the accelerated expansion of the universe.
Signals for vector-like leptons in an $$S_3$$-symmetric 2HDM at ILC
Authors: Chakraborty Indrani , Ghosh Dilip Kumar , Ghosh Nivedita , Rai Santosh Kumar 
Published: June 2022

AbstractIn this work, we explore the signals of an $$S_3$$

S
3

-symmetric two Higgs doublet model with two generations of vector-like leptons (VLLs) at the proposed International Linear Collider (ILC). The lightest neutral component of the VLL in this model provides a viable dark matter (DM) candidate satisfying the current relic density data as well as circumventing all direct and indirect DM search constraints. Some representative benchmark points have been selected with low, medium and high DM masses, satisfying all theoretical and experimental constraints of the model and constraints coming from the DM sector. The VLLs (both neutral and charged) will be produced in pair leading to multi-lepton and multi-jet final states. We show that the ILC will prove to be a much more efficient and useful machine to hunt for such signals compared to LHC. Using traditional cut-based analysis as well as sophisticated multivariate analysis, we perform a detailed analysis of some promising channels containing mono-lepton plus di-jet, di-lepton, four-lepton and four jets along with missing transverse energy in the final state at 1 TeV ILC.
Animal navigation: how animals use environmental factors to find their way
Authors: Wiltschko Roswitha , Wiltschko Wolfgang 
Published: June 2022

AbstractAnimals use the geomagnetic field and astronomical cues to obtain compass information. The magnetic compass is not a uniform mechanism, as several functional modes have been described in different animal groups. The Sun compass requires the internal clock to interpret the position of the Sun. For star compass orientation, night-migrating birds seem to use the star pattern as a whole, without involving the internal clock. Both the astronomical compass mechanisms are based on learning processes to adapt them to the geographic latitude where the animals live and, in long-living animals, to compensate for the seasonal changes. Several mechanisms are used to determine the compass course to a goal. Using information collected during the outward journey is mostly done by path integration: recording the direction with a compass and integrating its twists and turns. Migratory animals have innate programs to guide them to their still unknown goal. Highly mobile animals with large ranges develop a so-called navigational ‘map’, a mental representation of the spatial distribution of navigational factors within their home region and their migration route. The nature of the factors involved is not yet entirely clear; magnetic intensity and inclination are the ones best supported so far.
Simultaneously vanishing higher derived limits without large cardinals
Authors: Bergfalk Jeffrey , Hrušák Michael , Lambie-Hanson Chris 
Published: June 2022

A question dating to Mardešić and Prasolov’s 1988 work [S. Mardešić and A. V. Prasolov, Strong homology is not additive, Trans. Amer. Math. Soc. 307(2) (1988) 725–744], and motivating a considerable amount of set theoretic work in the years since, is that of whether it is consistent with the ZFC axioms for the higher derived limits [Formula: see text] [Formula: see text] of a certain inverse system [Formula: see text] indexed by [Formula: see text] to simultaneously vanish. An equivalent formulation of this question is that of whether it is consistent for all [Formula: see text]-coherent families of functions indexed by [Formula: see text] to be trivial. In this paper, we prove that, in any forcing extension given by adjoining [Formula: see text]-many Cohen reals, [Formula: see text] vanishes for all [Formula: see text]. Our proof involves a detailed combinatorial analysis of the forcing extension and repeated applications of higher-dimensional [Formula: see text]-system lemmas. This work removes all large cardinal hypotheses from the main result of [J. Bergfalk and C. Lambie-Hanson, Simultaneously vanishing higher derived limits, Forum Math. Pi 9 (2021) e4] and substantially reduces the least value of the continuum known to be compatible with the simultaneous vanishing of [Formula: see text] for all [Formula: see text].
DEAF-BSL: Deep lEArning Framework for British Sign Language recognition
Authors: Kumar Krishan 
Published: June 2022

The recent development of disability studies in academic bodies has expedited the promotion of investigation on disability. With computer-aided tools, communication between the impaired person and someone who does not understand sign language could be accessible. A large number of people across the world are using sign language (e.g.,
British Sign Language (BSL)
,
Asian Sign Language (ASL)
,
Indian Sign Language (ISL)
, etc.) with hand gestures for communication. In BSL recognition, the involvement of both hands overlapping each other becomes the main challenge. Moreover, BSL comprises ambiguous signs concerning viewpoint. However, existing traditional techniques seem in-stable, less accurate, and inefficient. In this work, the BSL fingerspelling alphabet recognition problem explores using a Deep learning framework to address the above-mentioned concerns.
Convolutional Neural Network (CNN)
is employed to detect and recognize for classification of 26 alphabets after being trained on the BSL corpus dataset. The proposed work outperforms the existing works with better precision (6%), recall (4%), and F-measure (5̃%). It reported better results on the BSL corpus dataset and webcam videos. The model achieved better accuracy (98.0%) for a large lexicon of words than previous models (Goh & Holden [
6
]: 69.5%, Rambhau [
9
]: 79.2%, and Liwicki et al. [
8
]: 92.5%). The 3D CNN-based proposal performs robust hand detection, much more accurate sign recognition, more scalability, and less ambiguity in BSL finger-spelling recognition.
Algorithm 1027:
NOMAD
Version 4: Nonlinear Optimization with the MADS Algorithm
Authors: Audet Charles , Le Digabel Sébastien , Montplaisir Viviane Rochon , Tribes Christophe 
Published: June 2022

NOMAD
is a state-of-the-art software package for optimizing blackbox problems. In continuous development since 2001, it constantly evolved with the integration of new algorithmic features published in scientific publications. These features are motivated by real applications encountered by industrial partners. The latest major release of
NOMAD
, version 3, dates to 2008. Minor releases are produced as new features are incorporated. The present work describes
NOMAD
4, a complete redesign of the previous version, with a new architecture providing more flexible code, added functionalities, and reusable code. We introduce algorithmic components, which are building blocks for more complex algorithms and can initiate other components, launch nested algorithms, or perform specialized tasks. They facilitate the implementation of new ideas, including the
MegaSearchPoll
component, warm and hot restarts, and a revised version of the
PsdMads
algorithm. Another main improvement of
NOMAD
4 is the usage of parallelism, to simultaneously compute multiple blackbox evaluations and to maximize usage of available cores. Running different algorithms, tuning their parameters, and comparing their performance for optimization are simpler than before, while overall optimization performance is maintained between versions 3 and 4.
NOMAD
is freely available at www.gerad.ca/nomad
and the whole project is visible at github.com/bbopt/nomad.
Alternatively Spliced Form of Angiopoietin-2 as a New Vascular Rheostat
Authors: Kamiyama Miki , Augustin Hellmut G. 
Published: June 2022

AbstractAngiopoietin (ANPGT)–TIE signaling serves as a critical regulator of vessel maturation controlling vascular quiescence, maintenance, and homeostasis (primarily through ANGPT1–TIE2 signaling), as well as enabling vascular plasticity and responsiveness to exogenous cytokines (primarily through antagonistically acting ANGPT2). An alternatively spliced form of ANGPT2 (ANGPT2443) was first reported 20 years ago. Yet, little is known to this day about its biological functions. In this issue of Cancer Research, Kapiainen and colleagues report an elegant series of experiments adding to the complexity and contextuality of ANGPT–TIE signaling. The authors studied the function of ANGPT2443 in cellular experiments as well as in a genetic model in vivo, revealing that it is proteolytically cleaved into a lower molecular weight isoform (termed ANGPT2DAP) that lacks the superclustering domain necessary for multimer formation. When compared with full-length ANGPT2, ANGPT2443 and ANGPT2DAP showed lower binding affinity to α5β1 integrin, but were more potent inhibitors of ANGPT1–TIE2 signaling. Functionally, ANGPT2443 impaired vessel enlargement and vein morphogenesis during postnatal retinal angiogenesis. Tumor experiments in Angpt2443-expressing mice showed enhanced destabilization of the lung vasculature, with varying effects on metastasis. Taken together, the study provides important insight into the significance of ANGPT2 alternative splicing and identifies ANGPT2443 and ANGPT2DAP as a biological rheostat of ANGPT1–TIE2 signaling. Future work will need to characterize the relative ratios and functional contributions of the ANGPT2 variants in different pathophysiologic settings.See related article by Kapiainen et al., p. 129
eQTL Set–Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma
Authors: Wang Xiaoyu , Gharahkhani Puya , Levine David M. , Fitzgerald Rebecca C. , Gockel Ines , Corley Douglas A. , Risch Harvey A. , Bernstein Leslie , Chow Wong-Ho , Onstad Lynn , Shaheen Nicholas J. , Lagergren Jesper , Hardie Laura J. , Wu Anna H. , Pharoah Paul D.P. , Liu Geoffrey , Anderson Lesley A. , Iyer Prasad G. , Gammon Marilie D. , Caldas Carlos , Ye Weimin , Barr Hugh , Moayyedi Paul , Harrison Rebecca , Watson R.G. Peter , Attwood Stephen , Chegwidden Laura , Love Sharon B. , MacDonald David , deCaestecker John , Prenen Hans , Ott Katja , Moebus Susanne , Venerito Marino , Lang Hauke , Mayershofer Rupert , Knapp Michael , Veits Lothar , Gerges Christian , Weismüller Josef , Reeh Matthias , Nöthen Markus M. , Izbicki Jakob R. , Manner Hendrik , Neuhaus Horst , Rösch Thomas , Böhmer Anne C. , Hölscher Arnulf H. , Anders Mario , Pech Oliver , Schumacher Brigitte , Schmidt Claudia , Schmidt Thomas , Noder Tania , Lorenz Dietmar , Vieth Michael , May Andrea , Hess Timo , Kreuser Nicole , Becker Jessica , Ell Christian , Tomlinson Ian , Palles Claire , Jankowski Janusz A. , Whiteman David C. , MacGregor Stuart , Schumacher Johannes , Vaughan Thomas L. , Buas Matthew F. , Dai James Y. 
Published: June 2022

Abstract

Background:
Over 20 susceptibility single-nucleotide polymorphisms (SNP) have been identified for esophageal adenocarcinoma (EAC) and its precursor, Barrett esophagus (BE), explaining a small portion of heritability.

Methods:
Using genetic data from 4,323 BE and 4,116 EAC patients aggregated by international consortia including the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), we conducted a comprehensive transcriptome-wide association study (TWAS) for BE/EAC, leveraging Genotype Tissue Expression (GTEx) gene-expression data from six tissue types of plausible relevance to EAC etiology: mucosa and muscularis from the esophagus, gastroesophageal (GE) junction, stomach, whole blood, and visceral adipose. Two analytical approaches were taken: standard TWAS using the predicted gene expression from local expression quantitative trait loci (eQTL), and set-based SKAT association using selected eQTLs that predict the gene expression.

Results:
Although the standard approach did not identify significant signals, the eQTL set–based approach identified eight novel associations, three of which were validated in independent external data (eQTL SNP sets for EXOC3, ZNF641, and HSP90AA1).

Conclusions:
This study identified novel genetic susceptibility loci for EAC and BE using an eQTL set–based genetic association approach.

Impact:
This study expanded the pool of genetic susceptibility loci for EAC and BE, suggesting the potential of the eQTL set–based genetic association approach as an alternative method for TWAS analysis.
Emerging Roles of the Copper–CTR1 Axis in Tumorigenesis
Authors: Su Yaqing , Zhang Xiaomei , Li Shaoqiang , Xie Wei , Guo Jianping 
Published: June 2022

AbstractPhysiologic roles of copper in metabolic homeostasis have been well established; however, whether and how copper is dysregulated in tumors and contributes to tumorigenesis is not recapitulated. Here, we comprehensively summarize the potential origins of copper accumulation in diseases, especially in cancers, by dysregulating copper transporter 1 (CTR1) or ATPase copper transporting alpha/beta (ATP7A/B) and further demonstrate the underlying mechanism of copper contributing to tumorigenesis. Specifically, in addition to modulating reactive oxygen species (ROS), angiogenesis, immune response, and metabolic homeostasis, copper recently has drawn more attention by directly binding to oncoproteins such as MEK, ULK, Memo, and PDK1 to activate distinct oncogenic signals and account for tumorigenesis. In the end, we disclose the emerging applications of copper in cancer diagnosis and highlight the promising strategies to target the copper–CTR1 axis for cancer therapies.
Marcelo Cohen: la literatura hacia la epistemología
Authors: Martinez Luciana Noelia 
Published: June 2022

El presente trabajo analiza las vinculaciones entre literatura y epistemología en la obra del escritor argentino Marcelo Cohen. Su obra, la cual puede definirse claramente en el seno de la escritura de ciencia ficción, propone una radicalización del concepto de “literatura anticipativa” tradicional en el género. Es precisamente en los procesos de ficcionalización de los paradigmas epistemológicos de la cuántica y las teorías del caos que Cohen lleva su literatura a un límite, a partir del cual explora las posibilidades de la escritura como herramienta filosófico-epistemológica mediante la que podrían definirse nuevas ontologías y pensarse otras formas de organización social. En este sentido, el ejercicio escriturario se entiende como una peculiar forma de realismo en el que lo real sería indisociable de lo ficcional.