bluuebunny/crossref_metadata_2025_split huggingface dataset:
Firm innovation and technical capabilities for enhanced export performance: the moderating role of competitive intensity
Authors: Zhang Meng Di , Jedin Mohd Haniff 
Published: November 2022

PurposeDrawing on the resource-based view (RBV) and structure–conduct–performance (SCP) paradigm perspectives, this study aims to investigate the influence of the innovation and technical capabilities of exporting organisations on their export performance moderate by competitive intensity.Design/methodology/approachPrimary data were collected from 162 Chinese manufacturer–exporter companies operating across China. The conceptual framework of this study, which incorporated the impact of RBV and SCP paradigm determinants on export performance through the interaction effect of competitive intensity, was tested using structural equation modelling (Smart-PLS).FindingsResults show that the technical and innovation capabilities can increase its export success in international markets. Furthermore, this research finds that competitive intensity moderates the positive relationship between technical capability and export performance but not the relationship between innovation capability and export performance.Originality/valueThis study presents a holistic assessment of the export performance of manufacturer–exporter enterprises by accounting for the overlooked effect of organisational capabilities through the moderating function of competitive intensity. This study has far-reaching consequences for export academics and practitioners, including the fundamental concept of an internationalizing small- and medium-sized enterprises, especially the manufacturers.
An unusual blunt force trauma pattern and mechanism to the cranial vault: Investigation of an atypical infant homicide
Authors: Isaac Carolyn V. , Cornelison Jered B. , Devota Clara J. , Shattuck Brandy L. , Castellani Rudolph J. 
Published: November 2022

AbstractThis case report presents an unusual fracture pattern in the cranium of a four‐month‐old infant indicative of child abuse. Upon postmortem examination, the infant presented with numerous bilateral linear cranial fractures running perpendicular to the sagittal suture with depressed and curvilinear fractures apparent on the supra‐auricular surfaces of the cranium. Histological evidence indicates multiple traumatic events to the cranium. In addition, the stair‐step pattern of a parietal fracture may represent multiple contiguous fractures from repeated loading of the head at different times with variation of the focal points of compressive force. Additionally, the left humerus, left radius, and left ulna have healing metaphyseal fractures, and the left ulna also has an antemortem diaphyseal fracture which resulted in the distal metaphysis being rotated 45 degrees medially. Integration of autopsy, anthropological, and neuropathological reports for this case suggest multiple inflicted injury episodes with a repeated atypical mechanism(s) to the cranial vault of the infant. During investigative interviews, the caretaker admitted to squeezing the infant's head and neck on multiple occasions to quiet the child. This reported abusive mechanism is consistent with the pattern of symmetric cranial fractures and soft tissue injuries indicating asphyxiation. This case report provides forensic investigators with a potential trauma mechanism to explore in cases when a similar pattern of cranial trauma is observed and highlights the need for greater research on fracture propagation and fracture healing in the infant cranium.
Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature
Authors: Etesami Ifa , Kalantari Yasamin , Tavakolpour Soheil , Mahmoudi Hamidreza , Daneshpazhooh Maryam 
Published: November 2022

AbstractDrug‐induced cutaneous pseudolymphoma (CPL) is a common form of pseudolymphoma and there are numerous drugs associated with it. In this study, we performed a systematic review of the literature by searching PubMed/Medline and Embase databases to determine the most common drugs responsible for CPL and to define the demographic, clinical, histopathological and immunopathological characteristics of patients (updated on 30 December 2020). From 883 initially found articles, 56 studies (89 reported cases) were included. The mean age of patients was 54.4 ± 17.7 (ranging 8–86) years, and 46 (51.7%) were men. The median time interval between drug intake and CPL occurrence was 120 days (range 1–7300 days). The shortest median time interval between taking the drug and the onset of the disease was observed among patients taking antidepressants (60 days) (range 7–540) and the longest median time interval was observed in individuals using immunomodulators (300 days) (range 3–7300). The most‐reported drug categories causing CPL were anti‐hypertensives (17.9%), anticonvulsants (14.6%), monoclonal antibodies (13.4%) and antidepressants (11.2%). Moreover, the most common drugs were phenytoin (6.7%), amlodipine (5.6%), fluoxetine (5.6%) and carbamazepine (4.4%). Histopathological evaluation of 76 cases revealed 62 (81.5%) reports of T‐cell infiltrations. Furthermore, positive reports of CD4 (94.0%), CD8 (93.0%) and CD30 (87.5%) were noted. The lowest prevalence of CD30‐positive reports was observed among monoclonal antibodies. In conclusion, anti‐hypertensives, anti‐convulsants, monoclonal antibodies and anti‐depressants are the most common drugs responsible for CPL. It mostly presents in middle‐aged patients with almost no gender difference as pruritic papules, nodules and plaques.
Cervical neoplasia in relation to socioeconomic and demographic factors – a nationwide cohort study (2002–2018)
Authors: Jansåker Filip , Li Xinjun , Sundqvist Avalon , Sundquist Kristina , Borgfeldt Christer 
Published: November 2022

AbstractIntroductionCervical cancer is a major cause of mortality and morbidity. We aimed to estimate the association between sociodemographic factors and cervical neoplasia.Material and methodsIn this Swedish nationwide open cohort study, 4 120 557 women aged ≥15 years at baseline were included between January 1, 2002 and December 31, 2018. The two outcomes were cervical cancer and carcinoma in situ identified in the Swedish Cancer Register. Sociodemographic factors (age, education level, family income level, region of residency, country of origin) were the main predictors. Incidence rates per 10 000 person‐years were calculated. Cox regression was used to estimate hazard ratios. Sensitivity analyses were conducted, including parity, urogenital infections, alcohol‐ and drug‐use disorders, and chronic obstructive pulmonary disease (used as a proxy for tobacco abuse).ResultsIn 38.9 million person‐years of follow‐up, 5781 (incidence rate: 1.5, 95% confidence interval [CI] 1.4–1.5) and 62 249 (incidence rate 16.9, 95% CI 15.9–16.1) women were diagnosed with cervical cancer and carcinoma in situ, respectively. Women from Eastern Europe had a hazard ratio of 1.18 (95% CI 1.05–1.33) for cervical cancer compared with Swedish‐born women, while women from non‐Western regions were inversely associated with cervical cancer and carcinoma in situ. Women with a low education level had a hazard ratio of 1.37 (95% CI 1.29–1.45) for cervical cancer compared with women with a high education level.ConclusionsWomen from the Middle East and Africa living in Sweden seem to suffer less from cervical neoplasia, whereas women with low education and women from Eastern Europe seem to suffer more from cervical cancer.
A note on the use of rank‐ordered logit models for ordered response categories
Authors: Johnson Timothy R. 
Published: November 2022

AbstractModels for rankings have been shown to produce more efficient estimators than comparable models for first/top choices. The discussions and applications of these models typically only consider unordered alternatives. But these models can be usefully adapted to the case where a respondent ranks a set of ordered alternatives that are ordered response categories. This paper proposes eliciting a rank order that is consistent with the ordering of the response categories, and then modelling the observed rankings using a variant of the rank ordered logit model where the distribution of rankings has been truncated to the set of admissible rankings. This results in lower standard errors in comparison to when only a single top category is selected by the respondents. And the restrictions on the set of admissible rankings reduces the number of decisions needed to be made by respondents in comparison to ranking a set of unordered alternatives. Simulation studies and application examples featuring models based on a stereotype regression model and a rating scale item response model are provided to demonstrate the utility of this approach.
The gut microbiome reflects ancestry despite dietary shifts across a hybrid zone
Authors: Nielsen Danny P. , Harrison Joshua G. , Byer Nathan W. , Faske Trevor M. , Parchman Thomas L. , Simison W. Brian , Matocq Marjorie D. 
Published: November 2022

AbstractThe microbiome is critical to an organism's phenotype, and its composition is shaped by, and a driver of, eco‐evolutionary interactions. We investigated how host ancestry, habitat and diet shape gut microbial composition in a mammalian hybrid zone between Neotoma lepida and N. bryanti that occurs across an ecotone between distinct vegetation communities. We found that habitat is the primary determinant of diet, while host genotype is the primary determinant of the gut microbiome—a finding further supported by intermediate microbiome composition in first‐generation hybrids. Despite these distinct primary drivers, microbial richness was correlated with diet richness, and individuals that maintained higher dietary richness had greater gut microbial community stability. Both relationships were stronger in the relative dietary generalist of the two parental species. Our findings show that host ancestry interacts with dietary habits to shape the microbiome, ultimately resulting in the phenotypic plasticity that host–microbial interactions allow.
Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients
Authors: Zare Maryam , Hesampour Fatemeh , Poordast Tahereh , Valibeigi Maryam , Enayatmehri Maliheh , Ahmadi Sahar , Nasri Fatemeh , Gharesi‐Fard Behrouz 
Published: November 2022

AbstractEndometriosis is an inflammatory disease characterized by the presence of ectopic endometrial tissue, immune cell dysfunction and abnormal cytokine secretion. In addition to immunological factors, genetic variations that influence endometriosis severity and cytokine expression levels play important roles in the pathogenesis of this disease. Interleukin‐12 (IL‐12), specifically its p40 subunit encoded by IL‐12B gene and the interleukin‐12 receptor β1 (IL‐12Rβ2) chain of its receptor, as well as interleukin‐27 (IL‐27) are important in the establishment of endometriosis. So, in this study, we measured IL‐12 and IL‐27 serum levels and investigated the possible links between IL‐12B rs3212227, IL‐12Rβ2 rs3790565 and IL‐27 rs153109 polymorphisms and the risk of developing endometriosis in a group of Iranian women. In this case‐control study, 162 endometriosis patients and 151 healthy women were included and tested for the aforementioned polymorphisms using the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) technique. The enzyme‐linked immunosorbent assay (ELISA) method was also used to measure IL‐12 and IL‐27 serum levels. Although there was no statistically significant association between the genotypes and alleles of the studied polymorphisms and the development of endometriosis in general, the AA genotype of IL‐12B rs3212227 showed a significant association with uterine endometriosis when compared to AC+CC genotypes (p = .04, CI = 0.270–0.988, OR = 0.517). Indeed, the AA genotype of the IL‐12B rs3212227 single nucleotide polymorphism (SNP) may be linked with a lower risk of developing uterine endometriosis. There was no significant difference in IL‐27 levels between the two studied groups (p = .49), and IL‐12 levels were undetectable in both groups. In conclusion, the AA genotype of IL‐12B rs3212227 might be associated with a decreased risk of uterine involvement in endometriosis patients.
Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways
Authors: Uy Jessica P. , Tan Ai Peng , Broeckman Birit B.F.P. , Gluckman Peter D. , Chong Yap Seng , Chen Helen , Fortier Marielle V. , Meaney Michael J. , Callaghan Bridget L. 
Published: November 2022

BackgroundExperiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early‐life trauma on child health remain unknown.MethodsThe current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7–8 years, as indexed by parent‐reported internalizing problems and child self‐reported anxiety and depressive symptoms (N = 268–418).ResultsGreater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting‐state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes.ConclusionsFindings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences.
Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review
Authors: Prinz Jörg C. , Choon Siew Eng , Griffiths Christopher E. M. , Merola Joseph F. , Morita Akimichi , Ashcroft Darren M. , Viguier Manuelle 
Published: November 2022

AbstractGeneralized pustular psoriasis (GPP) is a rare auto‐inflammatory skin disease characterised by acute episodes of sterile pustule formation. Diagnosis and treatment of the disease have historically been complicated by a lack of awareness, and no consistent global definition or clinical coding standards. Now acknowledged as a distinct clinical entity with a recognised genetic component, GPP can take a serious and life‐threatening course due to systemic inflammatory complications and its association with various comorbidities. As with other rare diseases, there are significant challenges to understanding the epidemiology of GPP, notably a small patient population, non‐standardised study methodologies and ethnic differences in its presentation. A clearer understanding of GPP is therefore required for clinicians to better manage patients with this rare condition. In this review article, we present an overview of the available data on GPP prevalence estimates in key demographics and report the frequency of genetic mutations associated with the disease. We detail the incidence of known comorbidities and summarise the data on mortality and assigned causes of death. Lastly, we discuss the various factors that impact the collection, interpretation and comparison of these data.
Experience on switching trientine formulations in Wilson disease: Efficacy and safety after initiation of TETA 4HCl as substitute for TETA 2HCl
Authors: Mohr Isabelle , Bourhis Hélène , Woimant France , Obadia Mickael Alexandre , Morgil Müzeyyen , Morvan Erwan , Merle Uta , Denk Gerald , Poujois Aurelia , Weiss Karl Heinz 
Published: November 2022

AbstractBackground and AimThis retrospective, multicenter study aims to assess the efficacy and safety in Wilson disease (WD) patients treated with trientine tetrahydrochloride (TETA 4HCl) after switch from trientine dihydrochloride (TETA 2HCl).MethodsIn total, 68 WD patients with stable copper metabolism were identified to receive TETA 4HCl (Cuprior™) after previous treatment with TETA 2HCl. We analyzed biochemical markers such as urinary copper, serum copper, non‐coeruloplasmin bound copper (NCC), and transaminases as well as clinical scores (APRI; FIB‐4 score) at baseline with a follow‐up (FU) of 12 months. Safety of TETA 4HCl treatment was based on reported adverse events (AEs).ResultsThe study cohort reflects a common WD cohort with a mean age of 20.3 years at diagnosis and 38.3 years at baseline. There are no significant differences concerning serum copper, NCC, transaminases, APRI, and FIB‐4 score in the 3‐month FU. Six‐month FU revealed a decreased AST (P = 0.008), APRI (P = 0.042), and FIB‐4 score (P = 0.039). GGT varied only borderline significantly in the 3‐month, but not in the 6‐month FU. Comparison of urinary copper within the subsets did not reveal a difference to baseline in all FUs, suggesting stable control of copper metabolism. Few AEs during TETA 4HCl treatment were reported, most commonly gastrointestinal discomfort. Only three treatments with TETA 4HCl were discontinued.ConclusionCopper parameters and liver function were stable after treatment switch to TETA 4HCl. Treatment with TETA 4HCl was generally well tolerated. This study indicates that the switch from TETA 2HCl to TETA 4HCl is safe and viable.
Clinical characterization of epileptic seizures in Pomeranians with idiopathic epilepsy or epilepsy of unknown cause
Authors: Yu Yoshihiko , Hasegawa Daisuke , Kanazono Shinichi , Saito Miyoko 
Published: November 2022

AbstractBackgroundFocal epileptic motor seizures manifested by limb contraction have been recognized anecdotally in Pomeranians.ObjectivesTo investigate clinical features of idiopathic epilepsy (IE) and epilepsy of unknown cause (EUC) in Pomeranians as well as the ADAM23 haplotype frequency previously reported as a common risk haplotype for epilepsy in several breeds of dogs.AnimalsTwenty‐eight Pomeranians, including 15 with IE and 13 with EUC. Nine Pomeranians with epilepsy and 8 control Pomeranians were used for ADAM23 risk haplotype analysis.MethodsCase series study including both retrospectively and prospectively collected cases. The ADAM23 haplotype was determined by direct sequencing of PCR amplicons. Data were analyzed descriptively.ResultsFocal epileptic seizures (FS) were the predominant type of seizure in 22 of 28 dogs (78.6%). Among these, 12 of the IE dogs (80.0%) and 10 of the EUC dogs (76.9%) showed FS. Notably, 21 of 22 Pomeranians with FS (95.5%) showed limb contraction during ictal periods. Some dogs with FS also showed immobility, generalized tremors, difficulty walking or moving, autonomic signs, orofacial automatisms or some combination during ictal events. Ten dogs with FS and limb contraction had electroencephalography (EEG) performed, and interictal epileptiform discharges were identified in 9 dogs. The haplotype frequency of ADAM23 in cases was lower (27.8%) than that of the controls (56.3%).Conclusions and Clinical ImportanceIn our study, FS was the predominant type of seizure in Pomeranians, and almost all cases with FS showed limb contraction, regardless of whether having IE or EUC.
miR‐141‐3p affects β‐catenin signaling and apoptosis by targeting Ubtd2 in rats with anorectal malformations
Authors: Wang Chen Yi , Li Si Ying , Xiao Yun Xia , Zhen Lin , Wei Xiao Gao , Tang Xiao Bing , Yuan Zheng Wei , Bai Yu Zuo 
Published: November 2022

AbstractAnorectal malformations (ARMs) are the most common gastrointestinal malformations. miR‐141‐3p was obtained from whole‐transcriptome sequencing, and Ub domain‐containing protein 2 (Ubtd2) was predicted as the target gene. An ARM rat model was induced using ethylenethiourea. Fluorescence in situ hybridization and immunofluorescence were used to detect the spatiotemporal expression of miR‐141‐3p and Ubtd2, respectively. A dual‐luciferase reporter assay confirmed their targeting relationship, and cell proliferation and apoptosis were investigated after transfection in the intestinal epithelium (IEC‐6). Additionally, western blotting and co‐immunoprecipitation were used to examine the protein levels and the endogenous binding relationship. miR‐141‐3p was downregulated in the ARM group, whereas Ubtd2 increased and colocalized with TUNEL‐positive cells. After miR‐141‐3p inhibition, protein expression of USP5 and β‐catenin was affected via Ubtd2, and USP5 could bind to both Ubtd2 and β‐catenin. Flow cytometry analysis and caspase 3/7 staining demonstrated that downregulated miR‐141‐3p promoted cell apoptosis through Ubtd2. In summary, targeting Ubtd2 decreased in miR‐141‐3p and promoted apoptosis of intestinal epithelium and regulated β‐catenin expression. This may cause aberrant apoptosis during hindgut development and mediate the imbalance of β‐catenin signaling in the cloaca, further affecting the occurrence of ARMs.
Limitation of sucrose biosynthesis shapes carbon partitioning during plant cold acclimation
Authors: Kitashova Anastasia , Adler Stephan O. , Richter Andreas S. , Eberlein Svenja , Dziubek Dejan , Klipp Edda , Nägele Thomas 
Published: November 2022

AbstractCold acclimation is a multigenic process by which many plant species increase their freezing tolerance. Stabilization of photosynthesis and carbohydrate metabolism plays a crucial role in cold acclimation. To study regulation of primary and secondary metabolism during cold acclimation of Arabidopsis thaliana, metabolic mutants with deficiencies in either starch or flavonoid metabolism were exposed to 4°C. Photosynthesis was determined together with amounts of carbohydrates, anthocyanins, organic acids and enzyme activities of the central carbohydrate metabolism. Starch deficiency was found to significantly delay soluble sugar accumulation during cold acclimation, while starch overaccumulation did not affect accumulation dynamics but resulted in lower total amounts of \sucrose and glucose. Anthocyanin amounts were lowered in both starch deficient and overaccumulating mutants. Vice versa, flavonoid deficiency did not result in a changed starch amount, which suggested a unidirectional signalling link between starch and flavonoid metabolism. Mathematical modelling of carbon metabolism indicated kinetics of sucrose biosynthesis to be limiting for carbon partitioning in leaf tissue during cold exposure. Together with cold‐induced dynamics of citrate, fumarate and malate amounts, this provided evidence for a central role of sucrose phosphate synthase activity in carbon partitioning between biosynthetic and dissimilatory pathways which stabilizes photosynthesis and metabolism at low temperature.