bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Making of Index Numbers in the Early 1920s: A Closer Look at the Fisher-Mitchell Debate
Authors: Cruz-e-Silva Victor , Almeida Felipe 
Published: May 2022

Abstract
The systematic emergence of the test approach to index numbers took place in the early 1920s, a period marked by pluralism in American economics. Promoted by Irving Fisher, the test approach to index numbers aimed to select a universally valid, ideal formula for index numbers by employing a series of mathematical tests. However, from the first presentation of Fisher's approach, at the 1920 Annual Meeting of the American Statistical Association, to the publication of his book The Making of Index Numbers, in 1922, he faced a series of criticisms, not addressed to his ideal formula per se, but rather aimed at the very idea that a universal formula for index numbers could be singled out. The most prominent individuals involved in this debate were Wesley Mitchell, Warren Persons, Correa Walsh (Fisher's only supporter), and Allyn Young. Among them, the foremost representative of Fisher's antagonists was Mitchell. This study aims at reconstructing this antagonism, arguing that the disagreements between Fisher and Mitchell resulted from their different backgrounds and their distinct understandings of economics as a science. More specifically, this article illustrates how Fisher, as a mathematical economist, privileged a universalist conception of science, while Mitchell, as an institutionalist, understood economics as a contextual and historical discipline, and it illustrates how these preconceptions spilled over to their debates on index numbers. To illuminate such positions, this study explores their archival correspondence.
“Come vertute in petra prezïosa”
Authors: Pace Matteo 
Published: May 2022

AbstractAlthough in the last few decades scholars have dedicated much attention to the juridical world and the academic environment of Bologna and its flourishing university in the second half of the thirteenth century, totally uncharted territory are the connections between Guido Guinizzelli di Magnano (1230s–1276), judge, prosecutor, and one of the main literary references of the upcoming Dolce Stilnovo, and the professional activity of Taddeo Alderotti (1206/1215–1295), the catalyst of the new scientific trends of the Bolognese medical school. Guido Guinizzelli’s canzone “Al cor gentil” offers a groundbreaking theory of nobility that philosophically conflates love with nobility. This article argues that the philosophical progress of the canzone presents an understanding of medical and scientific terminology that must be put in contact with Taddeo and his interest in Avicenna’s medical philosophy. Guinizzelli’s correspondence between love and nobility is nurtured by Avicenna’s increasingly popular doctrine of forma specifica, which structures the reasoning and the examples of the vernacular poem. Guinizzelli therefore frames the idea of nobility in the heart of the lover as the forma specifica of the noble man, and conceives the lady as the divine intelligence that reduces to act his potentiality.
Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus
Authors: Xia Yingqian , Zhang Yizhi , Xu Min , Zou Xiaochuan , Gao Jun , Ji Mu-Huo , Chen Guiquan 
Published: May 2022

ABSTRACT
Recent evidence has shown that presenilin enhancer 2 (Pen2; Psenen) plays an essential role in corticogenesis by regulating the switch of apical progenitors (APs) to basal progenitors (BPs). The hippocampus is a brain structure required for advanced functions, including spatial navigation, learning and memory. However, it remains unknown whether Pen2 is important for hippocampal morphogenesis. To address this question, we generated Pen2 conditional knockout (cKO) mice, in which Pen2 is inactivated in neural progenitor cells (NPCs) in the hippocampal primordium. We showed that Pen2 cKO mice exhibited hippocampal malformation and decreased population of NPCs in the neuroepithelium of the hippocampus. We found that deletion of Pen2 neither affected the proliferative capability of APs nor the switch of APs to BPs in the hippocampus, and that it caused enhanced transition of APs to neurons. We demonstrated that expression of the Notch1 intracellular domain (N1ICD) significantly increased the population of NPCs in the Pen2 cKO hippocampus. Collectively, this study uncovers a crucial role for Pen2 in the maintenance of NPCs during hippocampal development.
A cell wall-associated gene network shapes leaf boundary domains
Authors: Bouré Nathalie , Peaucelle Alexis , Goussot Magali , Adroher Bernard , Soubigou-Taconnat Ludivine , Borrega Néro , Biot Eric , Tariq Zakia , Martin-Magniette Marie-Laure , Pautot Véronique , Laufs Patrick , Arnaud Nicolas 
Published: May 2022

ABSTRACT
Boundary domains delimit and organize organ growth throughout plant development almost relentlessly, building plant architecture and morphogenesis. Boundary domains display reduced growth and orchestrate development of adjacent tissues in a non-cell-autonomous manner. How these two functions are achieved remains elusive despite the identification of several boundary-specific genes. Here, we show using morphometrics at the organ and cellular levels that leaf boundary domain development requires SPINDLY (SPY), an O-fucosyltransferase, to act as cell growth repressor. Furthermore, we show that SPY acts redundantly with the CUP-SHAPED COTYLEDON transcription factors (CUC2 and CUC3), which are major determinants of boundaries development. Accordingly, at the molecular level CUC2 and SPY repress a common set of genes involved in cell wall loosening, providing a molecular framework for the growth repression associated with boundary domains. Atomic force microscopy confirmed that young leaf boundary domain cells have stiffer cell walls than marginal outgrowth. This differential cell wall stiffness was reduced in spy mutant plants. Taken together, our data reveal a concealed CUC2 cell wall-associated gene network linking tissue patterning with cell growth and mechanics.
Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila
Authors: Töpfer Uwe , Guerra Santillán Karla Yanín , Fischer-Friedrich Elisabeth , Dahmann Christian 
Published: May 2022

ABSTRACT
The basement membrane is a specialized extracellular matrix (ECM) that is crucial for the development of epithelial tissues and organs. In Drosophila, the mechanical properties of the basement membrane play an important role in the proper elongation of the developing egg chamber; however, the molecular mechanisms contributing to basement membrane mechanical properties are not fully understood. Here, we systematically analyze the contributions of individual ECM components towards the molecular composition and mechanical properties of the basement membrane underlying the follicle epithelium of Drosophila egg chambers. We find that the Laminin and Collagen IV networks largely persist in the absence of the other components. Moreover, we show that Perlecan and Collagen IV, but not Laminin or Nidogen, contribute greatly towards egg chamber elongation. Similarly, Perlecan and Collagen, but not Laminin or Nidogen, contribute towards the resistance of egg chambers against osmotic stress. Finally, using atomic force microscopy we show that basement membrane stiffness mainly depends on Collagen IV. Our analysis reveals how single ECM components contribute to the mechanical properties of the basement membrane controlling tissue and organ shape.
The lysine deacetylase activity of histone deacetylases 1 and 2 is required to safeguard zygotic genome activation in mice and cattle
Authors: Dang Yanna , Li Shuang , Zhao Panpan , Xiao Lieying , Wang Lefeng , Shi Yan , Luo Lei , Wang Shaohua , Wang Huanan , Zhang Kun 
Published: May 2022

ABSTRACT
The genome is transcriptionally inert at fertilization and must be activated through a remarkable developmental process called zygotic genome activation (ZGA). Epigenetic reprogramming contributes significantly to the dynamic gene expression during ZGA; however, the mechanism has yet to be resolved. Here, we find histone deacetylases 1 and 2 (HDAC1/2) can regulate ZGA through lysine deacetylase activity. Notably, in mouse embryos, overexpression of a HDAC1/2 dominant-negative mutant leads to developmental arrest at the two-cell stage. RNA-seq reveals that 64% of downregulated genes are ZGA genes and 49% of upregulated genes are developmental genes. Inhibition of the deacetylase activity of HDAC1/2 causes a failure of histone deacetylation at multiple sites, including H4K5, H4K16, H3K14, H3K18 and H3K27. ChIP-seq analysis exhibits an increase and decrease of H3K27ac enrichment at promoters of up- and downregulated genes, respectively. Moreover, HDAC1 mutants prohibit the removal of H3K4me3 by impeding expression of Kdm5 genes. Importantly, the developmental block can be greatly rescued by Kdm5b injection and by partially correcting the expression of the majority of dysregulated genes. Similar functional significance of HDAC1/2 is conserved in bovine embryos. Overall, we propose that HDAC1/2 are indispensable for ZGA by creating correct transcriptional repressive and active states in mouse and bovine embryos.
Dissecting the phenotypic variability of osteogenesis imperfecta
Authors: Garibaldi Nadia , Besio Roberta , Dalgleish Raymond , Villani Simona , Barnes Aileen M. , Marini Joan C. , Forlino Antonella 
Published: May 2022

ABSTRACT
Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1 and COL1A2 genes that encode the α1(I) and α2(I) collagen chains. Mutant collagen is partially retained intracellularly, impairing cell homeostasis. Upon secretion, it assembles in disorganized fibrils, altering mineralization. OI is characterized by a wide range of clinical outcomes, even in the presence of identical sequence variants. Given the heterotrimeric nature of collagen I, its amino acid composition and the peculiarity of its folding, several causes may underlie the phenotypic variability of OI. A deep analysis of entries regarding glycine and splice site collagen substitution of the largest publicly available patient database reveals a higher risk of lethal phenotype for carriers of variants in α1(I) than in α2(I) chain. However, splice site variants are predominantly associated with lethal phenotype when they occur in COL1A2. In addition, lethality is increased when mutations occur in regions of importance for extracellular matrix interactions. Both extracellular and intracellular determinants of OI clinical severity are discussed in light of the findings from in vitro and in vivo OI models. Combined with meticulous tracking of clinical cases via a publicly available database, the available OI animal models have proven to be a unique tool to shed light on new modulators of phenotype determination for this rare heterogeneous disease.
A brainstem preparation allowing simultaneous access to respiratory motor output and cellular properties of motoneurons in American bullfrogs
Authors: Amaral-Silva Lara do , Santin Joseph M. 
Published: May 2022

ABSTRACT
Breathing is generated by a complex neural circuit, and the ability to monitor the activity of multiple network components simultaneously is required to uncover the cellular basis of breathing. In neonatal rodents, a single brainstem slice can be obtained to record respiratory-related motor nerve discharge along with individual rhythm-generating cells or motoneurons because of the close proximity of these neurons in the brainstem. However, most ex vivo preparations in other vertebrates can only capture respiratory motor outflow or electrophysiological properties of putative respiratory neurons in slices without relevant synaptic inputs. Here, we detail a method to horizontally slice away the dorsal portion of the brainstem to expose fluorescently labeled motoneurons for patch-clamp recordings in American bullfrogs. This ‘semi-intact’ preparation allows tandem recordings of motor output and single motoneurons during respiratory-related synaptic inputs. The rhythmic motor patterns are comparable to those from intact preparations and operate at physiological temperature and [K+]. Thus, this preparation provides the ability to record network and cellular outputs simultaneously and may lead to new mechanistic insights into breathing control across vertebrates.
High Stabilization of Low Valency in a Homoleptic ortho-Hydroxybenzoate-bridged Paddlewheel Diruthenium(II,II) Complex
Authors: Kosaka Wataru , Watanabe Yudai , Itoh Chisa , Miyasaka Hitoshi 
Published: May 2022

Abstract
A paddlewheel-type homoleptic diruthenium(II,II) complex ([Ru2II,II]), [Ru2(o-OHPhCO2)4(THF)2] (o-OH), bridged by ortho-hydroxybenzoate (o-OHPhCO2−) and tetrahydrofuran (THF) coordinated at the axial position (Lax) was isolated. The use of meta- and para-substituted hydroxybenzoate (x-OHPhCO2−; x = m and p) produced the corresponding [Ru2II,III] species neutralized by deprotonation of one of the x-OHPhCO2− ligands. In the o-OH complex, the formation of intramolecular hydrogen bonds between the o-OH group and carboxylate oxygen atom stabilized the [Ru2II,II] species significantly.
Inclusive pedagogy in online simulation-based learning in undergraduate nursing education: A scoping review protocol
Authors: Langan Lisa , Halligan Phil , Frazer Kate , Darley Andrew , Goodman Lizbeth , Redmond Catherine 
Published: May 2022

Background: Education is recognised as a constitutional right, however, access to and participation in higher education can be challenging for some students. This has led to the development of various international and local initiatives promoting inclusion, which has increased student representation from marginalised groups. In order to support growing student diversity, teaching and learning (T&L) strategies must encompass inclusive pedagogical principles. Technological advancements have improved opportunities for online T&L strategies and these are becoming an integral component of curricula in undergraduate nursing programmes. Online simulation-based learning (SBL) has gathered momentum in nursing education over the past twenty years. However, it is unclear from the evidence-base how inclusive this educational approach is, and how it can best support the growing diversity among nursing students. This paper outlines the protocol for a scoping review that aims to systematically and comprehensively map the available published and unpublished literature on inclusive pedagogy in online SBL in undergraduate nursing education. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for systematic review protocols (PRISMA-P) guided this protocol. Arksey and O'Malley (2015) six-stage methodology framework, the Joanna Briggs Institute (JBI) guidelines (2005) and the PRISMA extension for scoping reviews (PRISMA-ScR) will guide the proposed scoping review. Conclusion: It is envisaged that this scoping review will give a broad overview of the evidence for inclusive pedagogy in online SBL at this point. The findings of this review will be used to inform future policy and the pedagogical and technological design of online SBL activities and assist nurse educators to meet the current requirement of inclusive practice.
Rewards and recognition for Canadian distributed medical education preceptors: a qualitative analysis
Authors: Bell Amanda , Johnston Aaron , Makwarimba Edward , Malhi Rebecca 
Published: May 2022

Background: Recognition of Distributed Medical Education (DME) preceptors by medical institutions ensures that important community-based training opportunities remain available to learners. Yet the literature seldom explores what rewards are meaningful to this population of teachers. The goal of our national project was to provide guidance to medical schools about the financial remuneration and non-financial rewards that are most valued by DME preceptors. Methods: In this qualitative study, we invited DME faculty members from all Canadian medical schools to participate in semi-structured interviews. Participants with a range of medical specialties, stages of career, and geographic locations were interviewed via Zoom videoconferencing. The sessions in English and French were audio-recorded and transcribed. We used line-by-line inductive coding and thematic analysis to examine participant talk about meaningful preceptor recognition. Results: Fourteen participants from multiple provinces were interviewed. Results indicated that the DME faculty are a diverse group of people with diverse needs. Most of the interviewees appreciated the rewards and recognition provided by their institutions but felt that there are areas for improvement. Recognition is not necessarily monetary and should be tailored to the needs and the values of the recipient. Other themes included: benefits and challenges of being a preceptor, current institutional structures and supports, and the impact of the pandemic on preceptors. Conclusions: The interviews highlighted the importance placed by preceptors on personal rewards and a wide variety of forms of recognition. Based on the findings, we suggest specific steps that medical institutions can take to support, engage, and recognize DME faculty.
Cloaked near-field probe for non-invasive near-field optical microscopy
Authors: Bernal Arango Felipe , Alpeggiani Filippo , Conteduca Donato , Opheij Aron , Chen Aobo , Abdelrahman Mohamed I. , Krauss Thomas F. , Alù Andrea , Monticone Francesco , Kuipers Laurens 
Published: May 2022

Near-field scanning optical microscopy is a powerful technique for
imaging below the diffraction limit, which has been extensively used
in biomedical imaging and nanophotonics. However, when the
electromagnetic fields under measurement are strongly confined, they
can be heavily perturbed by the presence of the near-field probe
itself. Here, taking inspiration from scattering-cancellation
invisibility cloaks, Huygens–Kerker scatterers, and cloaked sensors,
we design and fabricate a cloaked near-field probe. We show that, by
suitably nanostructuring the probe, its electric and magnetic
polarizabilities can be controlled and balanced. As a result,
probe-induced perturbations can be largely suppressed, effectively
cloaking the near-field probe without preventing its ability to
measure. We experimentally demonstrate the cloaking effect by
comparing the interaction of conventional and nanostructured probes
with a representative nanophotonic structure, namely, a 1D
photonic-crystal cavity. Our results show that, by engineering the
structure of the probe, one can systematically control its back action
on the resonant fields of the sample and decrease the perturbation by

>

70
%

with most of our modified probes, and
by up to 1 order of magnitude for the best probe, at probe-sample
distances of 100 nm. Our work paves the way for non-invasive
near-field optical microscopy of classical and quantum
nanosystems.
Association between history of HBV vaccine response and anti-SARS-CoV-2 spike antibody response to the BioNTech/Pfizer’s BNT162b2 mRNA SARS-CoV-2 vaccine among healthcare workers in Japan: A prospective observational study
Authors: Iwamoto Momoko , Ukimura Akira , Ogawa Taku , Kawanishi Fumiko , Osaka Naofumi , Kubota Mari , Mori Tatsuhiko , Sawamura Ritsuko , Nishihara Masami , Suzuki Tomio , Uchiyama Kazuhisa 
Published: May 2022

Introduction
Inadequate vaccine response is a common concern among healthcare workers at the frontlines of the COVID-19 pandemic. We aimed to investigate if healthcare workers with history of weak immune response to HBV vaccination are more likely to have weak responses against the BioNTech/Pfizer’s BNT162b2 mRNA SARS-CoV-2 vaccine.

Methods
We prospectively tested 954 healthcare workers for the Anti-SARS-CoV-2 spike (S) protein antibody titers prior to the first and second BNT162b2 vaccination doses and after four weeks after the second dose using Roche’s Elecsys® assay. We calculated the percentage of patients who seroconverted after the first and second doses. We estimated the relative risk of non-seroconversion after the first BNT162b2 vaccine (defined as anti-SARS-CoV-2-S titer <15 U/mL) among HBV vaccine non-responders (HBs-Ab titer <10 mIU/mL) and weak responders (≥10 and <100 mIU/mL) compared to normal responders (≥100 mIU/mL).

Results
Among 954 healthcare workers recruited between March 9 and March 24, 2021 at Osaka Medical and Pharmaceutical University, weak and normal HBV vaccine responders had comparable S-protein titers after the first BNT162b2 dose (51.4 [95% confidence interval 25.2–137.0] versus 59.7 [29.8–138.0] U/mL, respectively). HBV vaccine non-responders were more likely than normal responders to not seroconvert after a single dose (age and sex-adjusted relative risk 1.85 95% confidence interval [1.10–3.13]) although nearly all participants seroconverted after the second dose. After limiting the analysis to 382 patients with baseline comorbidity data, the comorbidity-adjusted relative risk of non-seroconversion among HBV vaccine non-responders to normal responders was 1.32 (95% confidence interval [0.59–2.98]).

Discussion
Long term follow-up studies are needed to understand if protective immunity against SARS-CoV-2 wanes faster among those with history of HBV vaccine non-response and when booster doses are warranted for these healthcare workers.
International Journal of Education Through Art, 18:1, Special Issue: ‘Reconciliation’, Nadine M. Kalin, Mira Kallio-Tavin, Sheri R. Klein and Alexandra Lasczik (eds) (2022)
Authors: Robinson Stefan 
Published: May 2022

Response of: International Journal of Education Through Art, 18:1, Special Issue: ‘Reconciliation’, Nadine M. Kalin, Mira Kallio-Tavin, Sheri R. Klein and Alexandra Lasczik (eds) (2022)
Bristol: Intellect Ltd., 136 pp.
Controversial Issues and their Impact on the Construction and Reshaping of EFL Learners' Habitus
Authors: Ortiz López Juan Eduardo , Keitt Tracey 
Published: May 2022

The following study aims to explore Bourdieu’s notion of habitus and its shaping and re-shaping through exposure of authentic oral input. The study used podcasts as an EFL teaching strategy where learners were expected to confront their dispositions. For the purpose of this study, the mental illness issue was employed as a controversial topic. The research used a grounded theory approach and multi-case study design where three unstructured interviews were implemented in each case along the teaching process. Content analysis was applied and research generated categories emerged from the coding process. The results reveal that the EFL learning process has the potential to become a subversive form of defying culturally dominant dispositions and to enhance the learners’ probabilities of re-shaping habitus as well as learning a foreign language. According to the findings of this study, the inclusion of authentic controversial podcasts as listening comprehension tasks, which challenge EFL students’ habitus, can become a successful strategy to modify their cultural dispositions along with learning English as a foreign language.
Título: Manual para Docentes y Estudiantes Bisoños, Avezados, o Procrastinadores: Leer, Escribir e Investigar con Apoyo de las TIC
Authors: Castiblanco Abril Olga Lucía 
Published: May 2022

Biografía del autor

Rigoberto Castillo es Doctorado en Educación de University of Texas at Austin. Licenciado en Filología e Idiomas de la Universidad Nacional de Colombia. Profesor e investigador en la Universidad Distrital Francisco José de Caldas. Becario Fulbright y miembro del Grupo de Investigación Formación de Educadores. Profesor invitado de la Universidad San Buenaventura y Universidad de Caldas. El Dr. Castillo recibió de la Asociación Colombiana de Profesores de Inglés (ASOCOPI) el premio nacional Claire de Silva por sus aportes a la profesión. Email: rcastillo@udistrital.edu.co / ORCID: https://orcid.org/0000-0002-9527-0120