bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case for a Binary Black Hole System Revealed via Quasi-Periodic Outflows
Authors: Pasham Dheeraj , Tombesi Francesco , Sukova Petra , Zajaček Michal , Rakshit Suvendu , Coughlin Eric , Kosec Peter , Karas Vladimir , Masterson Megan , Mummery Andrew , Holoien Thomas , Guolo Muryel , Hinkle Jason , Ripperda Bart , Witzany Vojtěch , Shappee Ben , Kara Erin , Horesh Assaf , Velzen Sjoert van , Sfaradi Itai , Kaplan David , Burger Noam , Murphy Tara , Remillard Ronald , Steiner James , Wevers Thomas , Arcodia Riccardo , Buchner Johannes , Merloni Andrea , Malyali Adam , Fabian Andrew , Fausnaugh Michael , Daylan Tansu , Altamirano Diego , Payne Anna , Ferrara Elizabeth , Burke Jamison 
Published: November 2022

Abstract
Binary black hole systems in close orbits are thought to be the precursors of gravitational wave events and their identification has fundamental implications for our understanding of black hole growth and evolution. However, a gravitationally bound companion orbiting closer than about a milli-parsec to an accreting supermassive black hole (SMBH, mass ≥106 solar masses) in an external galaxy cannot be spatially resolved with present-day instruments. Instead, its detection requires a combination of indirect observational methods and advanced modelling. Here we report the detection of quasi-periodic variability in X-ray spectral features after an outburst from a previously low-luminosity Active Galactic Nucleus (AGN) in a galaxy at redshift z=0.056. We interpret this variability as due to Quasi-Periodic Outflows (QPOuts) from the SMBH. The puzzling phenomenon repeats roughly once every 8.5 days and photo-ionization modeling of the energy spectra implies that the outflowing material moves with a high velocity of about a third of the speed of light. The mass of the central black hole, roughly 30 million solar masses, as derived from the optical broad line--SMBH mass scaling relation, implies that the outflows are launched from a few tens of gravitational radii from the SMBH event horizon. By performing 2D and 3D general relativistic magnetohydrodynamic (GRMHD) simulations and by comparing their results over a broad range of the system parameters we show that these QPOuts can be explained with an orbiting intermediate-mass black hole (IMBH) secondary (mass range of 100--10,000 solar masses) at a distance of about 100 gravitational radii (less than a milli-parsec) from the primary SMBH. Outflows are naturally enhanced when the secondary object punches through the SMBH's inner accretion disc during each orbital period and this is revealed as regular increases in X-ray absorption along our line of sight. The overall optical, UV and X-ray outburst properties indicate that a major accretion episode -- perhaps from a stellar tidal disruption by the SMBH -- could have provided the gas to illuminate the presence of the pre-existing IMBH secondary. Our work highlights the new astrophysical phenomenon of QPOuts and the importance of high cadence X-ray monitoring observations to potentially uncover electromagnetic signatures of such tight binary black hole systems.
The mediating effect of coping style in the relationship between sleep status and quality of life among night shift nurses: a multistage stratified cluster sampling survey
Authors: Zhao Yan , Yang Bei , Liu Cui , Lin Benmiao , Wu Xiaoyi , Sun Yuanyuan , Chu Jianying 
Published: November 2022

Abstract
Background:
This study explored how coping styles mediate the relationship between sleep status and quality of life among night shift nurses.
Methods:
A multistage stratified cluster sampling survey was conducted among staff at a general hospital from November 2019 to January 2020. A total of 1,170 night shift nurses completed the Pittsburgh Sleep Quality Index (PSQI), EuroQol five-dimensions (EQ-5D), and Simplified Coping Style Questionnaire (SCSQ). Respectively, these measures were used to assess sleep quality, the quality of life, and coping styles.
Results:
The total sleep status was positively correlated with the quality of life (r = 0.31, P < 0.05) and negative coping (r = 0.18, P < 0.05), negatively correlated with positive coping (r = -0.05, P < 0.05). Negative coping was positively correlated with the quality of life (r = 0.42, P < 0.05). According to the path analysis, sleep status had a positive effect on negative coping (β = 0.18, P < 0.05) and quality of life (β = 0.11, P < 0.05), negative effect on positive coping (β = -0.05, P < 0.05); positive coping had a negative effect on quality of life (β = -0.03, P < 0.05), while negative coping had a positive effect on quality of life (β = 0.02, P < 0.05).
Conclusions:
Coping style partially mediated the relationship between sleep status and quality of life. This suggests that interventions targeting coping styles may benefit night shift nurses, as such an approach can ultimately enhance the quality of life by improving sleep.
A qualitative research on mental health and psychosocial issues impacting Syrian refugee women in Turkey
Authors: Çöl Meltem , Akın-Sarı Burçin , Mut Ayşe Nur Usturalı , Çelik Kezban , Aykut Nihal Bilgili , Dinç Leyla Ezgi , Koçak Cemal , Kobeissi Loulou , Say Lale , Akın Ayşe 
Published: November 2022

Abstract

Background: Due to the civil war since 2011, around 4 million Syrian refugees have migrated to Turkey from their home countries. It is well known that being a refugee, especially a female refugee, is considered to be one of the highest risk group in conflict areas. The psychological adaption challenges and extreme feelings of homesickness have resulted in mental health issues that are more prevalent among refugee women. This study aims to understand how context-specific factors influence Syrian refugee women’ psychosocial wellbeing and mental health through focus group discussions.
Methods: A total of 9 focus groups were conducted with Syrian women (4), Syrian men (3) and stakeholders (2). Qualitative assessment was used to examine the experiences related to the psychological health difficulties of Syrian women living in Turkey with temporary protection status. Thematic analysis was run to analyze the data by coding and identifying themes or patterns. In this study, their psychosocial problems, intention to seek professional help, access to existing services, challenges in access to, and expectations regarding these services were evaluated.
Results: Refugee women experience psychological and social difficulties just because they are women. Also, refugee women seem to be more vulnerable to psychological problems than men due to the effect of patriarchal ideology and the problems experienced before the forced migration.
Conclusions:Psychosocial well-being of Syrian refugee women is affected by the social, economic and political atmosphere, and it is important to develop policies that address the needs of these women.
WITHDRAWN: Preparation of resveratrol-loaded ethyl cellulose microspheres via foam- transfer and its application performances
Authors: Wang Yun , Gao Mengyuan , Pan Xiaolin , He Yanping P. , Liu Yuyang , Ji Mei , Si Tian , Sun Yanlin 
Published: November 2022

Abstract
Resveratrol (Res) has been widely used in personal-care and pharmaceutical products since it has anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. In this work, it was loaded by using biodegradable ethyl cellulose (EC) as the carrier to prepare EC/Res microspheresvia a foam-transfer method. The effects of experimental conditions on the properties of EC/Res microspheres were studied, and then their application performances including the sustained release and the degradation property were investigated. The results showed that resveratrol was loaded to EC microspheres successfully, in which EC/Res microspheres were in highly porous structures. Especially, when the PVA concentration = 2.5 wt%, the stirring rate = 600 rpm, the oil/water (O/W) ratio = 1:2, the polymer concentration = 1:25, the heating rate = 0.33 ℃/min, and the viscosity of ethyl cellulose = 90~110 mpa.s, the yield of EC/Res microspheres was up to 80.70 wt% with an encapsulation ratio of 73.89%; EC/Res microspheres were than produced continuously with an even higher encapsulation rate of resveratrol, which was 90.63% with a yield of 85.58 wt%. The cumulative release of EC/Res microsphere was up to 91.97 wt% in the phosphate buffer solution(PBS) at pH = 5.0 under 45 ℃ for 120 hours. After EC/Res microspheres degraded in PBS (pH = 7.4) for 45 days, their hardness decreased from 12.01 ± 0.56 MPa to 4.02 ± 0.45 MPa. This work provided a practical solution for resveratrol’s application as functional additives in a variety of areas.
Oregano essential oil and its main components Thymol and Carvacrol as alternatives to control citrus canker
Authors: Zamuner C. F. C. , Marin V. R. , Dilarri G. , Hypolito G. B. , Sass D. C. , Ferreira H. 
Published: November 2022

Abstract
Plant Essential Oils and their constituents are well-known for their properties as antimicrobial agents and are labeled as Generally Recognized as Safe (GRAS), prompting studies around their usage in the control of food-borne microorganisms and phytopathogens. In this study, we evaluated Oregano Essential Oil (OEO), Thymol (THY) and Carvacrol (CAR) for the control of Xanthomonas citri subsp. citri (X. citri). In vitro antibacterial assays revealed that CAR and THY inhibit X. citri growth at concentrations (100 ug.mL− 1 and 114 ug.mL− 1) lower than OEO (136 ug.mL− 1). Bactericidal effects were observed at 400 ug.mL− 1 for OEO and 200 ug.mL− 1 for CAR and THY. Investigating potential cellular targets for the compounds showed that after 30 minutes of exposure up to 84% of the cells had their membranes disrupted, prompting the membrane as the primary target. Phytotoxicicity evaluations using Lactuca sativa and Solanum lycopersicum seeds showed an acute toxic effect in all treatments above 200 µg.mL− 1, except for OEO and THY in S. lycopersicum at lower concentrations. Regarding their protective effect on citrus leaves, CAR showed no effect (0.39 lesions per cm2) when compared to the controls. OEO and THY were able to significantly reduce citrus canker symptoms (0.18 and 0.11 lesions per cm2, respectively). In addition, no toxic effects were observed on citrus leaves. THY inhibits X. citri growth and the development of citrus canker lesions. These results prompt THY as a viable alternative to be used in citrus canker management.
The mediating role of attitudes towards dementia on the relationship between dementia knowledge and behaviors towards persons with dementia: A cross-sectional study
Authors: Huang Hsiu-Li , Li Yang-Tzu , Bai Jing-Xuan , He Jia-Ming , Yang Shao-Wei 
Published: November 2022

Abstract

Background
The rising prevalence of dementia is a global health issue due to the worldwide increase in the number of adults over the age of 65 years. Persons living with dementia often experience discrimination in their life; thus, building a dementia-friendly community is important for reducing biases towards this population. The relationship between dementia knowledge, attitudes, and behaviors towards persons with dementia are significant factors in creating a dementia-friendly community. However, limited research has prevented a better understanding of the relationships among these variables. This study aimed to examine the mediating effect of attitudes towards dementia on the relationship between dementia knowledge and behaviors towards persons with dementia.
Methods
This was a cross-sectional survey with participants recruited from Wanhua District, Taipei City using a non-probability sampling method. Data were collected regarding dementia knowledge, attitudes, and behaviors using the Alzheimer’s Disease Knowledge Scale (ADKS), Approaches to Dementia Questionnaire (ADQ), and two researcher-developed self-administered survey questions on unfriendly behaviors towards persons with dementia, respectively. The correlation between dementia knowledge, attitudes, and unfriendly behaviors towards persons with dementia was determined with Pearson’s correlation coefficient. Multiple linear regressions investigated predictors of unfriendly behaviors towards persons with dementia. A simple mediation model was used to examine the mediation effect of attitudes on the relationship between dementia knowledge and unfriendly behaviors towards persons with dementia.
Results
A total of 313 participants were surveyed and the mean age of the respondents was 53.24 years (SD = 17.20; range = 20 to 90 years). Scores for dementia knowledge, attitudes and unfriendly behaviors towards persons with dementia were significantly correlated. Higher scores for knowledge (β=-0.16, p < 0.01) and attitudes towards dementia (β=-0.32, p < 0.001) were significantly associated with lower scores for unfriendly behaviors towards persons with dementia. A significant mediating effect of attitudes towards dementia was observed.
Conclusions
Attitudes towards dementia was a significant mediator in the relationship between dementia knowledge and unfriendly behaviors towards persons with dementia. Our findings suggest that increasing public awareness and knowledge about dementia could help the general population develop better attitudes towards dementia, which could subsequently help improve behaviors towards persons with dementia.
Antiplane fracture behavior of n nano-cracks emanating from a magnetoelectrically semi-permeable regular n-polygon nano-hole in magnetoelectroelastic materials
Authors: Wu Zhilin , Liu Guanting , Yang Dongsheng 
Published: November 2022

Abstract
Based on Gurtin Murdoch surface / interface model and complex potential theory, by constructing a new conformal mapping function, the fracture behavior on n nano-cracks emanating from a n-polygon nano-hole under far-field antiplane mechanical load, inplane electrical load and magnetic load is studied. The analytical solutions of stress intensity factor, electric displacement intensity factor and magnetic induction intensity factor at the crack tip are given under the boundary conditions of magnetoelectrically semi-permeable. In addition, numerical examples show that when considering the surface effect, the stress field intensity factor, electric displacement intensity factor and magnetic induction intensity factor have obvious size-dependence. The results of this paper show that when the defect size increases to a certain extent, the influence of the surface effect begins to decrease, and finally tends to the results of classical elastic theory.
Co-delivery of fucoxanthin and Twist siRNA using hydroxyethyl starch-cholesterol self-assembled polymer nanoparticles for triple-negative breast cancer synergistic therapy
Authors: Wu Zeliang , Tang Yuxiang , Chen Zhaozhao , Feng Yuao , Yu Dianwen , Hu Hang , Liu Hui , Chen Wei , Hu Yu , Xu Rong 
Published: November 2022

Abstract
Background: Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer with an extremely dismal prognosis and few treatment options. As a desmoplastic tumor, tumor cells are girdled by stroma composed of tumor-associated fibroblasts (CAFs) and their secreted stromal components. The rapidly proliferating tumor cells, together with the tumor stroma, exert additional solid tissue pressure on tumor vasculature and surrounding tissues, severely obstructing therapeutic agent from deep intratumoral penetration, and resulting in tumor metastasis and treatment resistance. Fucoxanthin (FX), a xanthophyll carotenoid abundant in marine algae, has attracted widespread attention as a promising alternative candidate for tumor prevention and treatment. Twist is a pivotal regulator of epithelial to mesenchymal transition (EMT), and its depletion has proven to sensitize antitumor drugs, inhibit metastasis, reduce CAFs activation and the following interstitial deposition, increase tumor perfusion, and allow more drugs to be delivered across the tumor stroma.
Results: Herein, our studies proposed a novel self-assembled polymer nanoparticle (siTwist/FX@HES-CH NPs) based on the amino-modified hydroxyethyl starch (HES-NH2) grafted with hydrophobic segment cholesterol (CH). Systematic studies demonstrated that the co-delivery strategy of natural product FX and nucleic acid drug Twist siRNA (siTwist) could not only synergistically kill tumor cells, but also inhibit the CAFs activation and extracellular matrix synthesis. Loose tumor stroma further facilitated transvascular transport and deep penetration of nanoparticles, obviously alleviating the primary tumor burden and inhibiting lung metastasis.
Conclusions: This dually functional nanomedicine that targets both tumor cells and tumor microenvironment (TME) could form a potent anti-TNBC therapeutic cyclical feedback loop, providing a new paradigm for TNBC treatment.
PCBP1 overexpression protects dopaminergic neurons in a model of Parkinson's disease
Authors: yang chen , li hongyan 
Published: November 2022

Abstract
PCBP1, known as poly(C)-binding protein, is a multifunctional protein produced by reverse transcription of the full-length mRNA of PCBP2. PCBP1 can regulate gene expression at the transcriptional level and can physically interact with other cellular proteins to alter their functional pathways. In our team's previous studies, overexpression of PCBP1 has been found to be closely related to oxidative stress, protein ubiquitination pathway, and iron death. In the present study, we provide evidence for a neuroprotective role of PCBP1 in dopaminergic neurons. Our data suggest that increased expression of PCBP1 in PC12 cells attenuates cellular damage caused by MPTP, including attenuated apoptosis and improved mitochondrial membrane potential. Overall, our data suggest a neuroprotective role for PCBP1 overexpression in dopaminergic neurons. These findings suggest that PCBP1 may have great therapeutic potential for the treatment of diseases associated with dopaminergic neuron loss, such as PD.
Toxic epidermal necrolysis (TEN) after sclerosing tissue glue injection in oesophageal variceal ligation in patients with liver malignant tumors: A case report
Authors: Hao Liangchao , Cai Wei , Geng Xiuchao , Li Qiang , Zeng Zhaomu , Chen Hong , Zhang Yuhao , Ding Juan 
Published: November 2022

Abstract
Background
Toxic epidermal necrolysis (TEN) is one of the few allergic diseases with an acute onset and severe symptoms in dermatology. Drugs are the most important pathogenic factors for this condition. Referring to the relevant literature, TEN after endoscopic surgery has been rarely reported.
Case presentation:
A 58-year-old male patient with chronic liver disease was treated with oesophageal variceal ligation, sclerosing agent and tissue glue injection due to oesophageal and gastric variceal bleeding. After 2 days, the patient’s skin exhibited erythema to different degrees. After 10 days of dexamethasone treatment, the whole-body rash worsened, and a severe skin reaction appeared, which was suggestive of toxic epidermal necrolysis (TEN). Strict mucosal care was provided, and corticosteroids, gamma globulin and adalimumab were concurrently used for treatment. After 20 days, the patient recovered from the skin problems.
Conclusion
Combined with domestic and international case reports, this may be the first case report of toxic epidermal necrolysis after sclerosing tissue glue injection in oesophageal variceal ligation. When patients with multiple drugs have multiline erythema, physicians should be alert to the possibility of its development into TEN. This article summarizes the experiences of this patient and related diagnoses and treatments at home and abroad, which provides a practical clinical basis and experience for the diagnosis and treatment of TEN in the future.
Portrayals of Electronic Cigarette Use; A Content Analysis of News Coverage by Online News Sites in Africa
Authors: Ngoma Chimwemwe 
Published: November 2022

Abstract
Background
Electronic cigarette use has become an international phenomenon in recent years, with many countries reporting an increase in the number of electronic cigarette users. Despite this, it remains largely unclear how news about the use of electronic cigarettes is portrayed in Africa. This study examined how news on electronic cigarette use is portrayed in Africa.
Methods
Content analysis was conducted to reveal the prevalence of codes and themes. A thematic analysis was also undertaken to explore how the choice of news sources influences news framing.
Results
The study found that positively framed articles and arguments about e-cigarettes in Africa outnumbered negatively framed articles and arguments. The study also found that the health impacts of electronic cigarettes were the most discussed topic and health authorities were the commonly used news sources.
Conclusion
Despite public health authorities being the main news source, the study found that there was a lack of unison in the argument on the safety of electronic cigarette use which could result in public health consequences, such as the formation of uninformed policies.
Persistent Myocardial Dysfunction Assessed by Global Myocardial Strain in Covid-19 Recovered Patients with Cardiovascular Comorbidities at 3 Months after Acute Infection
Authors: Tanto Ines Vidal , Sukmawan Renan , Liastuti Lies Dina , Mulya Erwin , Danny Siska Suridanda , Ariani Rina , Dwiputra Bambang , Hazami Zakky , Kusuma Nabilla Merdika , Kuncoro BRM Ario Soeryo 
Published: November 2022

Abstract
Background
Previous studies reported the Coronavirus disease (COVID-19) has long implications, which involve multiple organs, including the cardiovascular system. This study aims to assess myocardial dysfunction by echocardiograph myocardial longitudinal strain Left ventricular-Global Longitudinal Strain (LV-GLS) and Right Ventricular-Free Wall Strain (RV-FWS) measurements as a marker for myocardial dysfunction and heart fibrosis. Additionally, we aim to identify admission factors that may serve as a predictor of long COVID syndrome.
Methods
This cross-sectional study assessed echocardiograph global longitudinal strain (GLS) values measurement done three months after initial hospitalization. Multivariate analysis was done to investigate admission factors associated with differences in GLS values.
Results
100 subjects with cardiovascular comorbidities and prior COVID-19 infection were enrolled. Echocardiography examination showed lower GLS values in this group compared to the normal population. Demographic and risk factors-matched subjects without a history of COVID-19 (n = 31, Control 1) and healthy subjects (n-31, Control 2) were included as comparisons to validate GLS results. The case group had significantly lower LV-GLS values compared to other groups (p < 0.05, mean ± SD -16.17 ± 3.379, -19.48 ± 1.141, -21.48 ± 1.777 respectively for case, control one, and control two groups). Upon admission, a history of coronary artery disease was found to be associated with decreased LV GLS values in recovered COVID-19 patients with cardiovascular comorbidity.
Conclusion
LV GLS values significantly decreased in recovered COVID-19 patients with cardiovascular comorbidities. Upon admission, a history of CAD may predict cardiac long COVID-19 syndrome.