bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender-Based Differences in Response to Tumor Necrosis Factor Inhibitor Therapies for Ulcerative Colitis: Individual Participant Data Meta-Analyses of Clinical Trials
Authors: Agrawal Manasi , Petralia Francesca , Tepler Adam , Durbin Laura , Reinisch Walter , Colombel Jean-Frederic , Shah Shailja C 
Published: April 2022

AbstractBackgroundGender-based differences are reported in inflammatory bowel diseases (IBD) pathogenesis, but their impacts on IBD outcomes are not well known. We determined gender-based differences in response to treatment with tumor necrosis factor inhibitor (TNFi) therapies in individuals with ulcerative colitis (UC).MethodsWe used the Yale University Open Data Access (YODA) platform to abstract individual participant data from randomized clinical trials to study infliximab and golimumab as induction and maintenance therapies in moderately to severely active UC. Using multivariable logistic regression, we examined associations between gender and the endpoints of clinical remission, mucosal healing, and clinical response for each study individually and in a meta-analysis.ResultsOf 1639 patients included in induction trials (Program of Ulcerative Colitis Research Studies Utilizing an Investigational Treatment—Subcutaneous [PURSUIT-SC], active ulcerative colitis trials [ACT] 1 and 2) and 1280 patients included in maintenance trials (Program of Ulcerative Colitis Research Studies Utilizing an Investigational Treatment—Maintenance [PURSUIT-IM], ACT 1 and 2), 696 (42.5%) and 534 (41.7%) were women, respectively. In a meta-analysis of induction trials, the adjusted odds ratios (aORs) of clinical remission (aOR, 0.55; 95% CI, 0.31–0.97), mucosal healing (aOR, 0.47; 95% CI, 0.27–0.83), and clinical response (aOR, 0.51; 95% CI, 0.29–0.90) in the treatment arm and of clinical remission in the placebo arm (aOR, 0.34; 95% CI, 0.15–0.82) were lower in men compared to women. There were no differences in outcomes by gender in the treatment and placebo arms in the meta-analysis of maintenance trials.ConclusionsMen are less likely to achieve clinical remission, mucosal healing, and clinical response compared to women during induction treatment with TNFi for UC, but not during the maintenance phase. Future studies delineating the mechanisms underlying these observations would be informative.
Loss of Consciousness and Visual Hallucinations Related to 5-MeO-DALT Intake, a Case Report Confirmed by Toxicological Analyses
Authors: Dufayet Laurène , Langrand Jérôme , Alvarez Jean-Claude , Islam Larabi Amine 
Published: April 2022

Abstract
5-MeO-DALT or 5-methoxy-N,N-diallyltryptamine is a derivative of tryptamines, consumed for its hallucinogenic and entheogenic effects. We report the case of a 46-year-old-man, presenting with a brief loss of consciousness and visual hallucinations, after the consumption of three 5-MeO-DALT tablets bought online. Liquid chromatography coupled to tandem mass spectrometry method was performed, and 5-MeO-DALT was quantified in both the tablets (32.5 mg per tablet, 11% of purity) and the patient’s plasma (7 ng/mL—8 h between the consumption and the blood sample). 5-MeO-DALT poisonings are rarely described. Given the broad availability of these products, it is important that emergency department physicians and clinical toxicologists do not overlook the possibility of the ingestion of recreational tryptamines, especially since they are not detected by most routine toxicological screening.
Structural implications of potential field data on Southeastern North America
Authors: Alarifi Saad S 
Published: April 2022

AbstractThe fault system of Eastern Piedmont could be extensive in the East of the USA. Debates remain regarding the sutures zone, contacts and faults between terranes, especially underneath the coastal sediment. However, in this study, a new interpretation of the structures and contacts of the southeastern margin was based on regional land gravity anomaly and magnetic anomaly maps. To delineate and investigate the subsurface geological structures in the southern Appalachian belt and underneath the coastal sediment that covers the southeastern half of the study area, the gravity and magnetic maps were subjected to several filter techniques. The anomalies maps were enhanced by applying the reduction to pole (RTP), analytical signal (AS), tilt derivative (TDR), horizontal gradient (HG), direction filter and power spectrum techniques. The power spectrum filter was applied to separate the regional-residual anomaly. The results of regional anomaly maps display elongate high amplitude anomalies lie in the south that are related to deep-seated igneous mafic intrusive and basaltic lavas emplacement. The directional filter was used to eliminate the sutural trend of the Jurassic dikes that intruded the study area. The result displays the structural contacts clearly after removing the anomalies of the Jurassic. Finally, the edge detection filters (TDR, HG, AS) from the gravity and magnetic maps helped in mapping the anomaly contact of the subsurface bodies. The apparent structural signature of the interpreted contacts confirmed the presence of these structural features in all edge detection methods.
Factors Influencing Family Woodland Management Action After Calling a Public Agency Forester
Authors: Sagor Eli S , Sebald Martha J , Kilgore Michael A , Blinn Charles R , Snyder Stephanie A , Russell Matthew B 
Published: April 2022

Abstract
Many public agencies make foresters available to answer landowners’ land management questions. We gathered data about landowner calls to private forest management (PFM) foresters employed by a Minnesota state agency in 2017 and 2018. We used a mailed questionnaire to assess the outcomes of these contacts, including land management actions taken and factors most influential the landowner’s subsequent decision process. The most common topic landowners called about was enrolling in a property tax program, followed by harvesting and planting trees, obtaining financial assistance, and controlling forest pests. Eighteen months after the initial call, implementation rates and intent were high, ranging from 73%–91%. Across management actions, information from a PFM forester, likelihood of timely implementation, and expected benefit were highly influential. PFM calls also informed landowners about additional land management actions, many of which they implemented. Our results offer new insight into the value of landowner contact with public sector foresters.
Experimental study on erosion and wear law of metal screen under spraying condition
Authors: Ying Ruomeng , Zhao Xuankang , Shi Baocheng , Wu Lijuan , Zhang Xingkai , Jiang Ziheng , Guo Xiaochi 
Published: April 2022

ABSTRACT
It is very important for the safe production of sand producing oil and gas wells to make clear the erosion law of sand control screen pipe. The experiment of erosion law of metal mesh under two working conditions of blockage and non-blockage was carried out with jet erosion experimental device. The influencing factor of solid mass fraction (0.3%, 0.5%, and 0.8%), aperture velocity (1.5 m/s, 4 m/s, and 6 m/s) and particle size (20 μm, 54 μm, and 74 μm) on the erosion rate of metal mesh was analyzed. The results show that the mass loss of screen increases with the increase of solid mass fraction, aperture velocity and particle size, and the change law of single and double screens is consistent; under the condition of incomplete blockage, the mass loss of screen increases exponentially with the flow rate; under the condition of complete blockage, the balance flow rate of screen decreases with the increase of pressure difference when the pressure difference between inlet and outlet of screen is kept constant. In addition, the mass loss increases with the increase of pressure difference; in addition, the scanning electron microscope results of the erosion screen show that the erosion wear of the screen under the non-blocking condition is much less than that under the blocking condition, which is because the gap between the weft wires of the screen is blocked by particles, resulting in the rapid increase of the local aperture velocity of the screen, thus accelerating the local erosion wear of the screen.
Scattering of a scalene trapezoidal hill with a shallow cavity to SH waves
Authors: Sun Yingchao , Yang Zailin , Chen Lei , Mao Duanhua 
Published: April 2022

Abstract
Both surface ground motion and cavity stress concentration have always been considered in the designs of earthquake engineering. In this paper, a theoretical approach is used to study the scattering problem of circular holes under a scalene trapezoidal hill. The wave displacement function was obtained by solving the Helmholtz equation that meets the zero-stress boundary conditions by the variable separation method and the image method. Based on the complex function, the multipolar coordinate method and the region-matching technique, algebraic equations were established at auxiliary boundaries and free boundary conditions in the complex domain. Auxiliary circles were used to solve the singularity of the reflex angle at the trapezoidal corner. Then, according to the sample statistics, instead of the Fourier expansion method, the least-squares method was used to solve the undetermined coefficient of the algebraic equations by discrete boundaries. Frequency responses for some parameters were calculated and discussed. The numerical results demonstrate that the continuity of the auxiliary boundaries and the accuracy of the zero-stress boundary are good; the displacement of the free surface and the stress of the circular hole are related to the shape of the trapezoid, the position of the circular hole, the direction of the incident wave and the frequency content of the excitation. Finally, time-domain responses were calculated by inverse fast Fourier transform based on the frequency domain theory, and the results have revealed the wave propagation mechanism in the complicated structure.
Weight functions for an array of collinear cracks in an infinite anisotropic elastic plate
Authors: Wu Kuang-Chong , Chen Shyh-Haur 
Published: April 2022

Abstract
Weight functions are provided for calculating the stress intensity factors for collinear cracks in an infinite anisotropic elastic plate. The number of cracks as well as the length of the cracks are arbitrary. The weight functions are for crack-face loading, which may be non-self-equilibrium. It is shown that for self-equilibrium loading, the weight functions are independent of elastic constants. For non-self-equilibrium loading, however, an additional constant term that is material-dependent appears.
Integrated safety analysis of filgotinib treatment for rheumatoid arthritis in patients from Japan over a median of 1.5 years
Authors: Ishiguro Naoki , Tanaka Yoshiya , Matsubara Tsukasa , Atsumi Tatsuya , Amano Koichi , Sugiyama Eiji , Yamaoka Kunihiro , Winthrop Kevin , Kivitz Alan , Burmester Gerd R , Gottenberg Jacques-Eric , Genovese Mark C , Matzkies Franziska , Guo Ying , Jiang Deyuan , Bartok Beatrix , Pechonkina Alena , Kondo Akira , Besuyen Robin , Takeuchi Tsutomu 
Published: April 2022

ABSTRACT

Objective
Characterize safety of the Janus kinase-1 preferential inhibitor filgotinib (FIL) in Japanese patients with moderately to severely active rheumatoid arthritis (RA).

Methods
Data from three Phase 3 trials (NCT02889796, NCT02873936, and NCT02886728) and a long-term extension (NCT03025308) through September 2019 were integrated; patients received ≥1 dose of FIL 200 (FIL200) or 100 mg (FIL100) daily, or placebo (PBO). We calculated exposure-adjusted incidence rates (EAIRs) per 100 patient-years FIL exposure (100PYE) for treatment-emergent adverse events (TEAEs) and adverse events of special interest.

Results
Among 3691 total patients and 6080.7 PYE, 229 Japanese patients received FIL for 311.4 PYE (median 1.5, maximum 2.5 years). During the 12-week PBO-controlled period, serious TEAEs and TEAEs leading to study drug disruption were comparable between FIL and PBO. Serious infection rates were 1.9%, 0%, and 2% for FIL200, FIL100, and PBO during the PBO-controlled period; long-term FIL200 and FIL100 EAIRs were 3.8 and 2.1/100PYE. No herpes zoster (HZ) or major adverse cardiovascular events (MACEs) occurred during the PBO-controlled period; long-term FIL200 and FIL100 EAIRs were 3.0 and 2.1/100PYE (HZ) and 0.6 and 0/100PYE (MACE).

Conclusion
Long-term FIL treatment (median 1.5, maximum 2.5 years exposure) was well tolerated at 100- and 200-mg doses in Japanese patients with RA.
Do Smokers’ Perceptions of the Harmfulness of Nicotine Replacement Therapy and Nicotine Vaping Products as Compared to Cigarettes Influence Their Use as an Aid for Smoking Cessation? Findings from the ITC Four Country Smoking and Vaping Surveys
Authors: Yong Hua-Hie , Gravely Shannon , Borland Ron , Gartner Coral , Michael Cummings K , East Katherine , Tagliaferri Scott , Elton-Marshall Tara , Hyland Andrew , Bansal-Travers Maansi , Fong Geoffrey T 
Published: April 2022

Abstract

Introduction
This study examined whether smokers’ harm perceptions of nicotine replacement therapy (NRT) and nicotine vaping products (NVPs) relative to cigarettes predicted their subsequent use as smoking cessation aids during their last quit attempt (LQA).

Aims and Methods
We analyzed data from 1,315 current daily smokers (10+ cigarettes per day) who were recruited at Wave 1 (2016), and who reported making a quit attempt by Wave 2 (2018) of the International Tobacco Control Four Country Smoking and Vaping Surveys in Australia, Canada, England, and the United States. We used multinomial logistic regression models to examine prospective associations between harm perceptions of (a) NRT and (b) NVPs and their use at LQA, controlling for socio-demographic and other potential confounders.

Results
Smokers who perceive that (a) NRT and (b) NVPs are much less harmful than cigarettes were more likely to subsequently use the respective product as an aid than using no aid or other aids during LQA (adjusted relative risk ratio [aRRR] = 3.79, 95%CI = 2.16–6.66; and aRRR = 2.11, 95%CI = 1.29–3.45, respectively) compared to smokers who perceive these products as equally or more harmful. Additionally, those who perceive NVPs as much less harmful than cigarettes were less likely to use NRT as a quit aid (aRRR = 0.34, 95%CI = 0.20–0.60). No country variations for these associations were found.

Conclusions
This study found that smokers’ perceptions of the harmfulness of (a) NRT and (b) NVPs relative to cigarettes predicted the respective product use when trying to quit smoking. Corrective education targeting misperceptions of nicotine products’ relative harmfulness may facilitate their use for smoking cessation.

Implications
Nicotine replacement therapy and nicotine vaping products are two commonly used smoking cessation aids. This study demonstrates that misperceptions of the harms of nicotine products relative to cigarettes influence their use for smoking cessation. Believing that nicotine vaping products are much less harmful than cigarette smoking may lead some smokers to prefer these products over nicotine replacement therapy to aid smoking cessation. Education targeting misperceptions of nicotine products’ harmfulness relative to cigarettes may enable smokers to make informed choices about which are appropriate to aid smoking cessation.
Exposure to Negative News Stories About Vaping, and Harm Perceptions of Vaping, Among Youth in England, Canada, and the United States Before and After the Outbreak of E-cigarette or Vaping-Associated Lung Injury (‘EVALI’)
Authors: East Katherine , Reid Jessica L , Burkhalter Robin , Wackowski Olivia A , Thrasher James F , Tattan-Birch Harry , Boudreau Christian , Bansal-Travers Maansi , Liber Alex C , McNeill Ann , Hammond David 
Published: April 2022

Abstract

Introduction
Little is known about the international impact of E-cigarette or Vaping-Associated Lung Injury (‘EVALI’) on youth perceptions of vaping harms.

Methods
Repeat cross-sectional online surveys of youth aged 16–19 years in England, Canada, and the United States before (2017, 2018), during (2019 August/September), and after (2020 February/March, 2020 August) the ‘EVALI’ outbreak (N = 63380). Logistic regressions assessed trends, country differences, and associations between exposure to negative news stories about vaping and vaping harm perceptions.

Results
Exposure to negative news stories increased between 2017 and February–March 2020 in England (12.6% to 34.2%), Canada (16.7% to 56.9%), and the United States (18.0% to 64.6%), accelerating during (2019) and immediately after (February–March 2020) the outbreak (p &lt; .001) before returning to 2019 levels by August 2020. Similarly, the accurate perception that vaping is less harmful than smoking declined between 2017 and February–March 2020 in England (77.3% to 62.2%), Canada (66.3% to 43.3%), and the United States (61.3% to 34.0%), again accelerating during and immediately after the outbreak (p &lt; .001). The perception that vaping takes less than a year to harm users’ health and worry that vaping will damage health also doubled over this period (p ≤ .001). Time trends were most pronounced in the United States. Exposure to negative news stories predicted the perception that vaping takes less than a year to harm health (Adjusted Odds Ratio = 1.55, 1.48-1.61) and worry that vaping will damage health (Adjusted Odds Ratio = 1.32, 1.18-1.48).

Conclusions
Between 2017 and February–March 2020, youth exposure to negative news stories, and perceptions of vaping harms, increased, and increases were exacerbated during and immediately after ‘EVALI’. Effects were seen in all countries but were most pronounced in the United States.

Implications
This is the first study examining changes in exposure to news stories about vaping, and perceptions of vaping harms, among youth in England, Canada, and the United States before, during, and after ‘EVALI’. Between 2017 and February–March 2020, youth exposure to negative news stories, and perceptions of vaping harms, increased, and increases were exacerbated during and immediately after ‘EVALI’. By August 2020, exposure to negative news stories returned to 2019 levels, while perceptions of harm were sustained. Exposure to negative news stories also predicted two of the three harm perception measures. Overall, findings suggest that ‘EVALI’ may have exacerbated youth’s perceptions of vaping harms internationally.
Androgen receptor polyQ alleles and COVID-19 severity in men: a replication study
Authors: López-Rodríguez Rosario , Ruiz-Hornillos Javier , Cortón Marta , Almoguera Berta , Minguez Pablo , Pérez-Tomás María Elena , Barreda-Sánchez María , Mancebo Esther , Ondo Lorena , Martinez-Ramas Andrea , Fernández-Caballero Lidia ,   the STOP_Coronavirus Study Group, Paz-Artal Estela , Guillen-Navarro Encarna , Ayuso Carmen 
Published: April 2022

AbstractAmple evidence indicates a sex-related difference in severity of COVID-19, with less favorable outcomes observed in men. Genetic factors have been proposed as candidates to explain this difference. The polyQ polymorphism in the androgen receptor gene has been recently described as a genetic biomarker of COVID-19 severity. In this study, we analyzed this association in a large cohort of 1136 men classified into three groups according to their degree of COVID-19 severity, finding a similar distribution of polyQ alleles among severity groups. Therefore, our results do not support the role of this polymorphism as a biomarker of COVID-19 severity.
Association of Mass Distribution of Rapid Antigen Tests and SARS-CoV-2 Prevalence: Results from NIH-CDC funded Say Yes! Covid Test program in Michigan
Authors: Soni Apurv , Herbert Carly , Baek Jonggyu , Shi Qiming , Marquez Juan , Harman Emma , Kheterpal Vik , Nowak Chris , Suvarna Thejas , Lin Honghuang , Heetderks William , Zai Adrian , Cohen-Wolkowiez Michael , Corbie-Smith Giselle , Kibbe Warren , Gerber Ben S. , Hafer Nathaniel , Barton Bruce , Broach John , McManus David 
Published: April 2022

AbstractImportanceWide-spread distribution of diagnostics is an integral part of the United States’ COVID-19 strategy; however, few studies have assessed the effectiveness of this intervention at reducing transmission of community COVID-19.ObjectiveTo assess the impact of the Say Yes! Covid Test (SYCT!) Michigan program, a population-based program that distributed 20,000 free rapid antigen tests within Ann Arbor and Ypsilanti, Michigan in June-August 2021, on community prevalence of SARS-CoV-2.DesignThis ecological study analyzed cases of SARS-CoV-2 from March to October 2021 reported to the Washtenaw County Health Department.SettingWashtenaw County, MichiganParticipantsAll residents of Washtenaw CountyInterventionsCommunity-wide distribution of 500,000 rapid antigen tests for SARS-CoV-2 to residents of Ann Arbor and Ypsilanti, Michigan. Each household was limited to one test kit containing 25 rapid antigen tests.Main Outcome and MeasuresCommunity prevalence of SARS-CoV-2, as measured through 7-day average cases, in Ann Arbor and Ypsilanti was compared to the rest of Washtenaw County. A generalized additive model was fitted with non-parametric trends for control and relative differences of trends in the pre-intervention, intervention, and post-intervention periods to compare intervention municipalities of Ann Arbor and Ypsilanti to the rest of Washtenaw County. Model results were used to calculate average cases prevented in the post-intervention period.ResultsIn the post-intervention period, there were significantly lower standardized average cases in the intervention communities of Ann Arbor/Ypsilanti compared to the rest of Washtenaw County (p<0.001). The estimated standardized relative difference between Ann Arbor/Ypsilanti and the rest of Washtenaw County was -0.016 cases per day (95% CI: -0.020 to -0.013), implying that the intervention prevented 40 average cases per day two months into the post-intervention period if trends were consistent.Conclusions and RelevanceMass distribution of rapid antigen tests may be a useful mitigation strategy to combat community transmission of SARS-CoV-2, especially given the recent relaxation of social distancing and masking requirements.