bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diazepam diminishes temozolomide efficacy in the treatment of U87 glioblastoma cell line
Authors: Drljača Jovana , Popović Aleksandra , Bulajić Dragica , Stilinović Nebojša , Vidičević Novaković Sašenka , Sekulić Slobodan , Milenković Ivan , Ninković Srđan , Ljubković Marko , Čapo Ivan 
Published: June 2022

AbstractAimsMany patients with glioblastoma (GBM) suffer from comorbid neurological/psychiatric disorders and, therefore, are treated with psychopharmacological agents. Diazepam (DIA) is widely adopted to treat status epilepticus, alleviate anxiety, and inhibit chemotherapy‐associated delayed emesis in GBM patients. Even though temozolomide (TMZ) and DIA could be found as possible combination therapy in clinical practice, there are no reports of their combined effects in GBM. Hence, it may be of interest to investigate whether DIA enhances the antitumor efficacy of TMZ in GBM cells.MethodsU87 human GBM was used to examine the effects of combined TMZ and DIA on cell viability, and the oxygen consumption within the cells, in order to evaluate mitochondrial bioenergetic response upon the treatment.ResultsThe cooperative index showed the presence of antagonism between TMZ and DIA, which was confirmed on long‐term observation. Moreover, the level of apoptosis after the TMZ treatment was significantly decreased when administered with DIA (p < 0.001). Concomitant use of TMZ and DIA increased the basal cell respiration rate, the oxidative phosphorylation rate, and maximal capacity of mitochondrial electron transport chain, as well as the activities of complexes I and II, vs. TMZ alone (p < 0.001).ConclusionComparing our results with data reported that DIA elicits cell cycle arrest in the G0/G1 phase and favors senescence reveals that DIA diminishes TMZ efficacy in concomitant use in the treatment of GBM. However, due to its great potency to hinder GBM proliferation and metabolism, it could be considered using DIA as maintenance therapy after TMZ cycles.
Morning blood pressure surge in renal transplant recipients: Its relation to graft function and arterial stiffness
Authors: Demirci Bahar Gurlek , Afşar Barış , Tutal Emre , Colak Turan , Sezer Siren 
Published: June 2022

AbstractBackgroundWhen the blood pressure rises before awakening in the morning, it is called as morning blood pressure pulse (MBPS). MBPS is considered to be an independent risk factor for cardiovascular disease. The aim of this study was to investigate the associations between MBPS, graft function, arterial stiffness and echocardiographic indices in renal transplant recipients.MethodsAmong 600 renal transplant recipients, 122 patients who had a history of hypertension and were taking at least one antihypertensive medication were enrolled in the study. Arterial stiffness was measured by carotid‐femoral pulse wave velocity (PWv), and echocardiographic indices were assessed. 24 h ambulatory blood pressure was monitored for all patients. MBPS was calculated by subtracting morning systolic blood pressure from minimal asleep systolic blood pressure.ResultsMean morning, day time and asleep systolic blood pressure values were 171.2 ± 23.9, 137.9 ± 18.1, and 131.7 ± 18.9, respectively. Nondipper hypertension status was observed in 93 patients. Mean MBPS was 35.6 ± 19.5 mm Hg, means PWv was 6.5 ± 2.0 m/s. Patients with MBPS ≥ 35 mm Hg, had significantly lower eGFR and higher proteinuria, PWv. higher left atrium volume and LVMI. In regression analysis, day time systolic blood pressure, asleep systolic blood pressure, morning blood pressure surge, nondipper status and left ventricular mass index were detected as the predictors of graft function.ConclusionsIncreased morning blood pressure surge is associated with graft dysfunction, increased arterial stiffness and LVMI that contribute to cardiovascular mortality and morbidity in renal transplant recipients.
Prevalence and correlates of childhood‐onset bipolar disorder among adolescents
Authors: Barton Jessica , Mio Megan , Timmins Vanessa , Mitchell Rachel H. B. , Goldstein Benjamin I. 
Published: June 2022

AbstractAimEarly‐onset bipolar disorder (BD) is associated with a more severe illness as well as a number of clinical factors among adults. Early‐onset can be categorized as childhood‐ (age < 13) or adolescent‐ (age ≥ 13) onset, with the two displaying different clinical profiles. We set out to examine differences in clinical, and familial characteristics among adolescents with childhood‐ versus adolescent‐onset BD.MethodsThe study included 195 adolescents with BD, ages 14–18 years. Age of onset was determined retrospectively by self‐report. Participants completed the semi‐structured K‐SADS‐PL diagnostic interviews along with self‐reported dimensional scales. Analyses examined between‐group differences for clinical and familial variables. Variables associated with age of onset at p < 0.1 in univariate analyses were evaluated in a logistic regression model.ResultsApproximately one‐fifth of participants had childhood‐onset BD (n = 35; 17.9%). A number of clinical and familial factors were significantly associated with childhood‐onset BD. However, there were no significant differences in depressive and manic symptom severity. In multivariate analyses, the variables most strongly associated with childhood‐onset were police contact, and family history of suicidal ideation. Smoking and psychiatric hospitalization were associated with adolescent‐onset.ConclusionsIn this large clinical sample of adolescents with BD, one‐fifth reported childhood‐onset BD. Correlates of childhood‐onset generally aligned with those observed in the literature. Future research is warranted to better understand the genetic and environmental implications of high familial loading of psychopathology associated with childhood‐onset, and to integrate age‐related treatment and prevention strategies.
The representation of shape and texture in category‐selective regions of ventral‐temporal cortex
Authors: Coggan David D. , Watson David M. , Wang Ao , Brownbridge Robert , Ellis Christopher , Jones Kathryn , Kilroy Charlotte , Andrews Timothy J. 
Published: June 2022

AbstractNeuroimaging studies using univariate and multivariate approaches have shown that the fusiform face area (FFA) and parahippocampal place area (PPA) respond selectively to images of faces and places. The aim of this study was to determine the extent to which this selectivity to faces or places is based on the shape or texture properties of the images. Faces and houses were filtered to manipulate their texture properties, while preserving the shape properties (spatial envelope) of the images. In Experiment 1, multivariate pattern analysis (MVPA) showed that patterns of fMRI response to faces and houses in FFA and PPA were predicted by the shape properties, but not by the texture properties of the image. In Experiment 2, a univariate analysis (fMR‐adaptation) showed that responses in the FFA and PPA were sensitive to changes in both the shape and texture properties of the image. These findings can be explained by the spatial scale of the representation of images in the FFA and PPA. At a coarser scale (revealed by MVPA), the neural selectivity to faces and houses is sensitive to variation in the shape properties of the image. However, at a finer scale (revealed by fMR‐adaptation), the neural selectivity is sensitive to the texture properties of the image. By combining these neuroimaging paradigms, our results provide insights into the spatial scale of the neural representation of faces and places in the ventral‐temporal cortex.
War as a pretext to wave the rule of law goodbye? The case for an EU constitutional awakening
Authors: Bárd Petra , Kochenov Dimitry V. 
Published: June 2022

AbstractThe war in Ukraine triggered significant changes at the European Union level. The speed at which the EU has achieved progress on sanctions, migration and defense is particularly impressive. But the Russian aggression against Ukraine has also served as a pretext for putting aside internal discussions about the rule of law, and provided additional political rationales for inaction against Member State governments responsible for the violation of European values, as well as triggered the deepening of double standards in several fields. Against this background, the paper argues that using this crisis as a justification for further inaction in the context of EU values is not a sustainable course of action. The Union must not delay further the need to act to halt the insidious erosion of democracy and the rule of law within its own borders both at the national and supranational level.
Effect of the sequence of pull of bone marrow aspirates on plasma cell quantification in plasma cell proliferative disorders
Authors: Jain Garima , Das Nupur , Gajendra Smeeta , Gangwar Satya Prakash , Gupta Ritu , Mallik Saumyaranjan , Sharma Atul , Kumar Lalit , Upadhyay Ashish Datt 
Published: June 2022

AbstractIntroductionThe evaluation of plasma cell (PC) compartment is influenced by the quality of bone marrow aspirate (BMA). Herein, we evaluated the impact of sequence of pull on quality of clinical assessment in plasma cell proliferative disorders (PCPDs).MethodsHistomorphology along with smears from first pull and second pull BMA and flow cytometric immunophenotyping (FCMI) data from second pull aspirate were evaluated for cellularity and PC%.ResultsOf the 484 samples, BMA smears were adequate in 87.4% of first pull (median PC = 7%; IQR = 2–25%) and 51.2% of second pull samples (median PC = 2%; IQR = 0.5–12%; p < 0.001). Recovery of PC was least on FCMI (median PC = 0.59%; IQR = 0.14–3.07%), however, sample adequacy was met in 42.6% of samples with acquisition of ≥3 million events. Second pull smears under‐reported PC% in 34% of newly diagnosed multiple myeloma (NDMM) (<10% PC) and 46% of MM on therapy (<5% PC), resulting in suboptimal assessment. Bone marrow biopsy (BMBx) was evaluated in a total of 309 cases (median PC = 10.0%; IQR 4.0–40.0%) with significantly higher numbers of BMPC% on BMBx compared with first pull smears (Mean ± 2SD: 25.9% ± 30.54 vs. 20.77% ± 20.20; p = 0.001).ConclusionFirst pull BMA smears were of superior quality but inadequate in one‐tenth of samples. Second pull smears underreported PC% and recovery of PC compartment was poorest on FCMI. Concurrent bone marrow biopsy and use of the first pull sample for FCMI along with acquisition of a higher number of cells on FCMI may enhance the quality of assessment in PCPDs.
Effect of prophylactic central neck dissection following total thyroidectomy on surgical site wound infection, hematoma, and haemorrhage in subjects with clinically node‐negative papillary thyroid carcinoma: A meta‐analysis
Authors: Jin Lingshuang , Liu Limin , Wang Jing , Zhang Li 
Published: June 2022

AbstractWe performed a meta‐analysis to evaluate the effect of prophylactic central neck dissection following total thyroidectomy on surgical site wound infection, hematoma, and haemorrhage in subjects with clinically node‐negative papillary thyroid carcinoma. A systematic literature search up to April 2022 was performed and 3517 subjects with clinically node‐negative papillary thyroid carcinoma at the baseline of the studies; 1503 of them were treated with prophylactic central neck dissection following total thyroidectomy, and 2014 were using total thyroidectomy. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated to assess the effect of prophylactic central neck dissection following total thyroidectomy on surgical site wound infection, hematoma, and haemorrhage in subjects with clinically node‐negative papillary thyroid carcinoma using the dichotomous method with a random or fixed‐effect model. The prophylactic central neck dissection following total thyroidectomy subjects had a significantly lower surgical site wound infection (OR, 0.40; 95% CI, 0.20–0.78, P = .007) in subjects with clinically node‐negative papillary thyroid carcinoma compared with total thyroidectomy. However, prophylactic central neck dissection following total thyroidectomy did not show any significant difference in hematoma (OR, 0.08; 95% CI, 0.43–2.71, P = .87), and haemorrhage (OR, 0.72; 95% CI, 0.26–1.97, P = .52) compared with total thyroidectomy in subjects with clinically node‐negative papillary thyroid carcinoma. The prophylactic central neck dissection following total thyroidectomy subjects had a significantly higher surgical site wound infection, and no significant difference in hematoma, and haemorrhage compared with total thyroidectomy in subjects with clinically node‐negative papillary thyroid carcinoma. The analysis of outcomes should be with caution because of the low number of studies in certain comparisons.
Effect of particle size distribution on crystallization behavior of glass‐based seals in reversible solid oxide cells
Authors: Tao Mengxuan , Feng Jiangtao , Li Ruizhu , Guan Chengzhi , Pu Jian , Chi Bo 
Published: June 2022

AbstractReversible solid oxide cell (RSOC), integrating solid oxide fuel cell and solid oxide electrolysis cell, usually utilizes a glass material as seals. The particle size distribution of glass has a significant influence on crystallization and sintering behavior in the sealing process during RSOC operation. In this work, the effects of particle size on the non‐isothermal crystallization kinetics of BaO–ZnO–MgO–B2O3–SiO2 glass in RSOC are conducted. The crystallization behavior of glass is experimentally investigated and theoretically analyzed using Kissinger, Augis–Bennett, and Ozawa models. The values of crystallization activation energies are 164.4, 188.4, and 223.2 kJ/mol for 50, 150, and 300 μm (average particle sizes of S1, S2, and S3 glasses, respectively). The Avrami parameter (n) and dimensionality (m) of S1 glass are 0.6 and 0.7, similarly those of S2 glass were 0.9 and 0.7, corresponding to surface crystallization. However, the n and m values of S3 glass are both 1.8, suggesting that crystal growth between 1 (rod like) and 2 (plate like). Coarse glass exhibits better thermal stability and higher sluggishness to crystallize than that of fine glass. The main crystallization phases are characterized as thermally stable structure BaZn2Si2O7. Combined crystallization behavior with sintering behavior of glass, it is indicated that fine glass owns fast crystallization kinetics compared with sintering kinetics, generating a porous structure, whereas glass with larger particles crystallizes more slowly, exhibiting a relatively dense structure in RSOC operation.
Mineralogy, chronology and formation process of the epithermal gold–silver vein deposits in the historical Togi mine, Noto Peninsula, Japan
Authors: Hamada Maki , Kobayashi Wataru , Hiramatsu Yoshihiro , Hasebe Noriko 
Published: June 2022

AbstractTo determine local deposit features in the vein‐type gold–silver ore deposit of the historical Togi mine, Noto Peninsula, central Japan, we investigated the occurrence and chemical compositions of ore minerals, especially silver‐ and/or gold‐bearing minerals, and wall‐rock alteration in the Togo No. 3 tunnel, a major tunnel of the Urukami mining area of the Togi mine. In the tunnel, the stockwork veins which are generally 0.1–1.5 m wide runs in Neogene pyroxene andesite. In the ore‐bearing quartz vein, in addition to the sulfides such as sphalerite, pyrite and chalcopyrite, the following Au and/or Ag ore minerals were identified: electrum with <49.3 mol% Ag, uytenbogaardtite, fischesserite, silver‐rich minerals of the Ag2S–Ag2Se solid solution series, and Se‐rich pearceite. Gangue minerals in the quartz veins are quartz and adularia. The wall rock is silicified, chloritized, and sericitized pyroxene andesite. Multiple generations of adularia grown on quartz suggest that adularia has grown by repeatedly passing the hydrothermal solution through the vein. Based on the characteristic occurrence of the Ag and/or silver‐rich ore minerals such as electrum, fischesserite, and Se‐rich pearceite and a gangue mineral, adularia, and on the wall‐rock alteration characterized by chlorite, sericite, and calcite, the Togi deposit is classified as a Se‐type and low‐sulfidation epithermal gold vein deposit. The K‐Ar ages of illite/smectite mixed‐layer minerals from the altered outcrop and plagioclase from a fresh andesite sample are 17.68 ± 0.41 and 17.52 ± 0.43 Ma, respectively, in agreement with published data of the Besshodake andesite. These results indicate that the hydrothermal fluids generated by the Miocene andesitic magma activity infiltrated the fissures relating to the formation of the Togi‐gawa Nangan Fault at the northern boundary of the Togi mining area, and Au and/or Ag‐rich ore minerals were formed from the hydrothermal fluid with decreasing temperature at the shallow level.
SEIR Model to address the impact of face masks amid COVID‐19 pandemic
Authors: Maged Ahmed , Ahmed Abdullah , Haridy Salah , Baker Arthur W. , Xie Min 
Published: June 2022

AbstractEarly in the pandemic of coronavirus disease 2019 (COVID‐19), face masks were used extensively by the general public in several Asian countries. The lower transmission rate of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in Asian countries compared with Western countries suggested that the wider community use of face masks has the potential to decrease transmission of SARS‐CoV‐2. A risk assessment model named Susceptible, Exposed, Infectious, Recovered (SEIR) model is used to quantitatively evaluate the potential impact of community face masks on SARS‐CoV‐2 reproduction number (R0) and peak number of infectious persons. For a simulated population of one million, the model showed a reduction in R0 of 49% and 50% when 60% and 80% of the population wore masks, respectively. Moreover, we present a modified model that considers the effect of mask‐wearing after community vaccination. Interestingly mask‐wearing still provided a considerable benefit in lowering the number of infectious individuals. The results of this research are expected to help public health officials in making prompt decisions involving resource allocation and crafting legislation.
BaRTv2: a highly resolved barley reference transcriptome for accurate transcript‐specific RNA‐seq quantification
Authors: Coulter Max , Entizne Juan Carlos , Guo Wenbin , Bayer Micha , Wonneberger Ronja , Milne Linda , Schreiber Miriam , Haaning Allison , Muehlbauer Gary J. , McCallum Nicola , Fuller John , Simpson Craig , Stein Nils , Brown John W. S. , Waugh Robbie , Zhang Runxuan 
Published: June 2022

SUMMARYAccurate characterisation of splice junctions (SJs) as well as transcription start and end sites in reference transcriptomes allows precise quantification of transcripts from RNA‐seq data, and enables detailed investigations of transcriptional and post‐transcriptional regulation. Using novel computational methods and a combination of PacBio Iso‐seq and Illumina short‐read sequences from 20 diverse tissues and conditions, we generated a comprehensive and highly resolved barley reference transcript dataset from the European 2‐row spring barley cultivar Barke (BaRTv2.18). Stringent and thorough filtering was carried out to maintain the quality and accuracy of the SJs and transcript start and end sites. BaRTv2.18 shows increased transcript diversity and completeness compared with an earlier version, BaRTv1.0. The accuracy of transcript level quantification, SJs and transcript start and end sites have been validated extensively using parallel technologies and analysis, including high‐resolution reverse transcriptase‐polymerase chain reaction and 5'‐RACE. BaRTv2.18 contains 39 434 genes and 148 260 transcripts, representing the most comprehensive and resolved reference transcriptome in barley to date. It provides an important and high‐quality resource for advanced transcriptomic analyses, including both transcriptional and post‐transcriptional regulation, with exceptional resolution and precision.
Post‐protectorate Uganda and current models of influence across Englishes
Authors: Meierkord Christiane 
Published: June 2022

AbstractThis paper presents the overall results of a research project that investigated factors determining how speakers of Ugandan English express futurity, ability and obligation. Findings reveal that forms identified to convey these meanings in American, Indian, Kenyan or Nigerian English, and whose use would reveal influence from these, are seldom used. Rather, persisting exonormative orientation towards British English and first‐language influence seem to determine how many forms are tolerated and which ones are preferred. This challenges epicentre theory, according to which an endonormatively stable variety influences varieties in neighbouring countries, as well as models that assume that varieties with a high impact in terms of the demographic and economic weight of their speakers influence those with a lower impact, whilst findings furthermore indicate that regular long‐term exposure to another variety results in accommodation, making this a factor that needs to be better accounted for.
The Effect of Agricultural Modernization on Work Preferences in Batu, East Java, Indonesia
Authors: Yana Hamyana , Hidayat Kliwon , Sukesi Keppi , Yuliati Yayuk , Sofiana Eva 
Published: June 2022

This study aims to determine the effect of agricultural modernization on work preferences. There are two variables of agricultural modernization are used, which are the characteristics of human resources and farming characteristics. This type of research is survey research with a quantitative descriptive analysis. The location of this research was carried out in Batu on the respondents of Karang Taruna (Children of Farmers) aged 16-22 years. The sampling technique used the formula from Slovin to get 100 respondents. The sampling technique used Proportionate Random Sampling techniques and data collection methods through Google Form. Data analysis techniques in this study were the test instrument and multiple linear regression analysis. The results showed that there was a significant influence on the modernization of agriculture on work preferences for Karang Taruna in Junrejo District Batu.