bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transient adrenal insufficiency following treatment of rheumatoid arthritis with intramuscular methylprednisolone acetate
Authors: Angus Alisa , Giles Emily E. , Ogundipe Olayinka A. 
Published: August 2022

An 82-year-old woman presented with dizziness, a fall, and pubic fractures. She had resting severe hypertension, with marked orthostatic hypotension. She was recently diagnosed with cyclic citrullinated peptide (+) rheumatoid arthritis. She had received 120 mg intramuscular methylprednisolone (Depo-Medrone®) eight months prior, and a second dose a day preceding hospitalisation. Two days into the admission, her Glasgow coma scale (GCS) score dropped acutely from 15/15 (E4;V5;M6) to 3/15 (E1;V1;M1). The initial differential diagnoses were: an acute stroke (a total anterior circulation syndrome-TACS or brainstem stroke), opiate toxicity (fracture pains), and possible unwitnessed seizure (in a post-ictal state). Urgent computerised tomography (CT) brain was unremarkable. She had an acute-on-chronic hyponatraemia (nadir 121 mmol/L) while on long-term proton pump inhibitor therapy, and hyperkalaemia (peak 5.8 mmol/L). Initial management included intravenous (IV) naloxone, fluids and diazepam with poor clinical response. Due to persistent low GCS, the admitting team were concerned about a potentially guarded prognosis. However, based on the history of recent high dose steroid injections, plus the evolving clinical picture and abnormal biochemistry, empirical treatment was started (IV hydrocortisone 100 mg QDS and 0.9% saline infusion) for possible adrenal insufficiency. An ‘add-on’ request for random serum cortisol was made to her admission bloods, and returned low (33 nmol/L). With treatment, her GCS improved rapidly from 3/15 to 15/15. A subsequent planned short synacthen test was abnormal (cortisol level pre-synacthen 100; 30min post-synacthen 340), suggestive of adrenal insufficiency. Following consultation with endocrinology, she was maintained on oral hydrocortisone 10 mg (am)/5 mg(teatime) with sustained clinical improvement.
Impact of organized teaching programme on awareness of mothers regarding prevention of eye problems in children at selected rural areas of Kolar district
Authors: A. R. Harish Kumar , E. P. Elia Vivek 
Published: August 2022

Background: Depending on the geographical area and socioeconomic state of the population, numerous diseases can cause visual impairment and blindness in children. Blindness in children in underdeveloped nations is typically caused by illnesses that result in corneal scarring such as vitamin A deficiency, measles infection, neonatal conjunctivitis, and dangerous traditional eye medications. Cataract, retinopathy of prematurity, genetic disorders, and congenital anomalies are the most common causes elsewhere. This issue is complicated by a lack of information about eye care and utilization of eye treatments. Methods: For this study, an evaluative technique was applied. The data was collected using a one-group pre-test and post-test design. The organized teaching programme on prevention of eye problems in children was the study's independent variable, while the knowledge level of mothers on prevention of eye problems was the dependent variable. A structured interview schedule was utilized to collect data from 100 mothers who were recruited using the purposive sample technique.Results: In the pre-test, the mean percentage of total knowledge was 56.35, with a standard deviation of 2.37. The mean percentage of total knowledge in the posttest was 75.83, with a standard deviation of 1.37. The obtained t value of 24.70 was larger than the table value of 2.66 and it was judged to be significant at the threshold of 0.01.Conclusions: Study demonstrated that the organized education programme was successful in raising mothers' awareness about the prevention of eye disorders in children.
Radiofrequency ablation in Von-Hippel-Lindau disease with bilateral renal cell carcinoma: a case report
Authors: Shanmugam Subbiah , . Bharanidharan , C. H. Radha Siva Bharath 
Published: August 2022

<p class="abstract">Von Hippel-Lindau (VHL) disease is a familial form of renal cell carcinoma which manifests as bilateral renal cell carcinoma. Radiofrequency ablation is a minimally invasive technique helps in treating renal cell carcinoma with renal function preservation. We reported a case of 29 years old male with bilateral renal cell carcinoma. We treated him with left radical nephrectomy and right side multifocal RCC with Radio frequency ablation. Radiofrequency ablation definitely have a role as alternative treatment modality to nephron sparing surgical procedure for small (&lt;4 cm) localised RCC. Further studies are needed to assess its long-term efficacy.</p><p> </p>
Relation between Environmental Variables and the Spatial Distribution of the Aedes aegypti Mosquito in Rural Colombia
Authors: Cabezas Pinzón Laura Viviana , Sanabria-Marin Rigaud , Andrade-Rivas Federico , Darghan Aquiles , Olano Víctor-Alberto 
Published: August 2022

Background: Changes in global and local environmental variables condition the distribution and density of disease vectors. This study aimed to estimate the relationship between the entomological indicator of immature and adult forms of the Aedes aegypti mosquito per unit area, the environmental variables of temperature, precipitation, and relative humidity in rural areas of two municipalities in Colombia.
Methods: Four spatial regression models were fitted: The Spatial Autoregressive Model with Autoregressive Disturbances of order [1,1] (SARAR[1,1]), Spatial Error Model (SEM), Spatial Lag Model (SLM), and the Pure Spatial Autoregressive Model. Immature and adult A. aegypti forms were collected in homes during June 2013 (dry season). The houses were chosen at random and were georeferenced. Climate information was obtained from the Institute of Hydrology, Meteorology and Environmental Studies (IDEAM- Instituto de Hidrología, Meteorología y Estudios Ambientales). Climatic information was completed with mathematical interpolation from the Akima library.
Results: The most appropriate model was SARAR[1,1], as it showed the lowest values of the Akaike information criterion (AIC = 473.34). In this model, the variable that best explained the entomological indicator (immature and adult forms per unit area) was the altitude of the houses in the rural area where the entomological samples were collected. This means that the higher the altitude, the lower the entomological indicator calculated. The ranges of the environmental variables in which the presence of the mosquito occurred are between 602 to 1414 m.a.s.l (meters above sea level) for altitude, 17 °C to 27 °C for temperature, 27 mm to 86 mm for precipitation, and 70% to 85% for relative humidity.
Conclusions: The importance of understanding the relationship between local environmental characteristics and the presence of the vector for designing comprehensive management strategies was highlighted, contributing to better surveillance, prevention, and control of vectors and diseases transmitted by them.
Workplace Assessment Scale: Pilot Validation Study
Authors: Huang Eileen , Edgar Nicole E. , MacLean Sarah E. , Hatcher Simon 
Published: August 2022

First responders, such as police officers, paramedics, and fire-fighters are at an increased risk of experiencing negative mental health outcomes compared to the general population. This predisposition can partially be attributed to common occupational stressors, such as poor workplace culture and mistreatment from leadership, which may provoke strong feelings of betrayal and humiliation. The Workplace Assessment Scale (WAS) was developed as there is currently no appropriate measure to assess such feelings in the first responder population. The scale consists of the Betrayal Subscale and the Humiliation Subscale, each comprised of 5 Likert scale questions which ask participants to report the frequency at which they experience specific feelings associated with their workplace. This pilot validation study was conducted to assess preliminary reliability and validity of the WAS, using data which was originally collected as part of a larger first responder-based observational study. Based on 21/22 (95%) participant responses, the internal consistency appeared to be strong for both sub-scales as well as the overall questionnaire. However, item 9 will likely require modification or deletion from the scale. The validity analysis found no significant correlations between WAS and other psychiatric scales. Additional research is needed for further analysis and validation of the WAS.
Experimental and Field Investigations on the Impact-Resistance Mechanical Properties of Negative Poisson’s Ratio Bolt/Cable
Authors: Wang Jiong , Liu Peng , Ma Zimin , He Manchao , Gao Chengzhang , Zhu Chun 
Published: August 2022

Abstract
Dynamic impact tests of negative Poisson’s ratio (NPR) and rebar bolts under different impact wavelengths were carried out using a self-developed NPR bolt tensile impact test system. Additionally, a field anti-impact test using blasting was performed to simulate rockburst, and the field anti-impact characteristics of the NPR and conventional cable were compared and analysed. The experimental test results revealed that the peak impact force of the NPR and rebar bolts was inversely proportional to the wavelength. The NPR bolt underwent only constant resistance structural deformation, and the rod body did not break. The rebar bolt body fractured and necked. Under the same impact wavelength, the impact force and elongation of the two bolt types were proportional to the impact velocity. Compared with the greater peak impact force of the rebar bolt, the NPR bolt output structure deformation reduced the peak impact force. At the same impact velocity, as the wavelength increased, the impact force of the NPR bolt decreased rapidly, and the number of peaks also decreased. The impact force peak value of the rebar bolt was high, the impact force-time curve had multipeak characteristics, and no apparent rapid attenuation occurred. The field test results indicated that the NPR cable could produce slip deformation under the action of an explosion impact force to absorb the impact energy and that it had special mechanical properties to maintain a constant resistance. Under the same equivalent blasting impact energy, the conventional cable test section collapsed completely. The NPR cable test section was stable overall, verifying that the NPR cable had better impact-resistance mechanical properties than conventional cable. The research results provide a reliable basis for the effectiveness of NPR bolts/cables in preventing rockbursts.
Adaptive RISE Control of Winding Tension With Active Disturbance Rejection
Authors: Mi Junjie , Yao Jianyong , Deng Wenxiang 
Published: August 2022

Abstract
The winding system is a time-varying system that takes into account various complex nonlinear characteristics. Among them, how to control the stability of the winding tension during the winding process is the primary problem that has plagued the development of this field in recent years. There are many nonlinear factors that affect the tension in the winding process, such as friction, structured, unstructured uncertainties and external interference. These terms severely restrict the performance of the tracking error of tension. Previously, the existing tension control strategies were mainly based on the composite control of the tension loop and the speed loop, and the research was carried out through complex decoupling operations. Due to the large calculation amount of this method, it brings a lot of inconvenience in practical engineering applications. For this purpose that further simplify the tension generation mechanism and the influence of the nonlinear characteristics of the winding system, a simpler nonlinear dynamic model of the winding tension was established. At the same time, an adaptive method was applied to update the feedback gain of the continuous robust integral of the sign of the error (RISE). Furthermore, extended state observer (ESO) was used to estimate the modeling errors and external disturbances. Then, the model disturbance term can be compensated in the designed controller of RISE. The asymptotic stability of the system is prove based on the stability theory of Lyapunov. Finally, a comparative analysis was carried out between the proposed nonlinear controller and several other controllers. Results show that the tracking error of winding tension was enhanced significantly.
Paraoxonase-2 contributes to promoting lipid metabolism and mitochondrial function via autophagy activation
Authors: Shin Gu-Choul , Lee Hyeong Min , Kim Na Yeon , Yoo Sang-Ku , Park Hyung Soon , Choi Leo Sungwong , Kim Kwang Pyo , Kim Kyun Hwan 
Published: August 2022

Abstract
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent immuno-metabolic disease that can progress to hepatic cirrhosis and cancer. NAFLD pathogenesis is extremely complex and is characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Thus, in-depth research on its underlying mechanisms and subsequent investigation into a potential drug target that has overarching effects on these features will help in the discovery of effective treatments for NAFLD. Our study examines the role of endogenous paraoxonase-2 (PON2), a membrane protein with reported antioxidant activity, in an in vitro cell model of NAFLD. We found that the hepatic loss of PON2 activity aggravated steatosis and oxidative stress under lipotoxic conditions, and our transcriptome analysis revealed that the loss of PON2 disrupts the activation of numerous functional pathways closely related to NAFLD pathogenesis, including mitochondrial respiratory capacity, lipid metabolism, and hepatic fibrosis and inflammation. We found that PON2 promoted the activation of the autophagy pathway, specifically the mitophagy cargo sequestration, which could potentially aid PON2 in alleviating oxidative stress, mitochondrial dysfunction, lipid accumulation, and inflammation. These results provide a mechanistic foundation for the prospect of PON2 as a drug target, leading to the development of novel therapeutics for NAFLD.
On MXene Conducting Polymer Nanocomposites Micro-Supercapacitors and Applications
Authors: Idumah Christopher Igwe 
Published: August 2022

AbstractDue to escalating evolution of micro-electronics utilized in wearable, as well as flexible electronics, the quests for micro-batteries along with micro-supercapacitors (MSCs) has increased tremendously. MSCs have attracted increasing interests as a result of the development occurring in scope of these energy storing micro-architectures. Appropriate electrode material selection constitutes a fundamental choice in design and fabrication of MSCs. Presently, an emerging class of two-dimensional transitional metallic (M) carbides or nitrides (X) referred as 2-D MXene (M-X) has emanated and pronounced efficient for energy storage. Hence, as a result of inherently elevated electronic conductivity of 10,000 S cm− 1, elevated charge storing efficiency, and ease of processability, M-X has demonstrated high prospects for fabrication of MSC electrodes. Thus, M-X has been versatily utilized in stacked form or within inter-digitalized system for on-chip MSCs. Therefore, this paper elucidates recently emerging trends in M-X hybrids and conducting polymeric nanoarchitecture oriented energy storing systems especially for MSCs, Metal-ion batteries and other energy storage systems.
AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Authors: Zhang Ruihong , Liu Luguang , Wang Fengqin , Zhao Weizhu , Liu Kai , Yu Hang , Zhao Siwei , Xu Botao , Zhang Xiaoli , Chai Jie , Hao Jing 
Published: August 2022

Abstract
Gastric cancer (GC) remains the third leading cause of cancer-related deaths. Chemoresistance is the major determinant of GC treatment failure. To explore the molecular mechanisms of GC chemoresistance, mass spectrometry was performed to detect the genes altered in expression between chemoresistant and chemosensitive GC. PRKA kinase anchor protein 8L (AKAP-8L) was identified as one of the top upregulated genes in chemoresistant GC tissues. Moreover, the higher AKAP-8L expression was associated with the lower survival rate in GC patients. Overexpression of AKAP-8L enhanced the GC cell stemness and chemoresistance of oxaliplatin in vivo and in vitro. AKAP-8L deficiency obtained the opposite results. Mechanistically, AKAP-8L interacted with Stearoyl-CoA desaturase 1 (SCD1) mRNA and IGF2BP1 protein, and regulated SCD1 mRNA stability via IGF2BP1-dependent manner. SCD1 played a critical role in mediating the function of AKAP-8L in GC cell stemness and chemoresistance. Clinically, AKAP-8L and SCD1 protein levels was positively associated with human GC chemoresistance. Taken together, our results demonstrated that AKAP-8L facilitates GC chemoresistance via regulating SCD1-mediated stemness of GC cells. AKAP8L may represent a novel therapeutic target to overcome GC chemoresistance.
Targeting Aurora-A Inhibits Tumor Progression and Sensitizes Thyroid Carcinoma to sorafenib by decreasing PFKFB3-mediated glycolysis
Authors: Zhi Jingtai , Hu Linfei , Kang Ning , Yun Xinwei , Wang Xin , Ruan Xianhui , huang dongmei , Yang Weiwei , Meng Xiangrui , Wang Wei , Zheng Xiangqian 
Published: August 2022

Abstract
Background
Thyroid cancer (TC) is the most common endocrine tumor, amongst which anaplastic thyroid carcinoma (ATC) is the most deadly. Aurora-A usually functions as oncogenes, and its inhibitor Alisertib exerts a powerful antitumor effect in various tumors. However, the mechanism of Aurora-A in regulating TC cell energy supply remains unclear.
Methods
Phosphoproteome and proteome analyses and RNA-seq were performed to investigate the molecular mechanisms of Aurora-A-induced tumor cell progression, which were further verified by in vitro modulations of Aurora-A and related pathways. An immunohistochemistry assay was carried out to evaluate the relationship between Aurora-A and patient prognosis. Finally, the antitumor efficacy of the Alisertib/Sorafenib combination was assessed in vitro and in vivo.
Results
We demonstrated the antitumor effect of Alisertib and an association between high Aurora-A expression and shorter survival. Multi-omics data and in vitro validation data suggested that Aurora-A induced PFKFB3-mediated glycolysis to increase ATP supply, which significantly upregulated the phosphorylation of ERK and AKT. The combination of Alisertib and Sorafenib had a synergistic effect, further confirmed in xenograft models and in vitro.
Conclusions
We provide compelling evidence of the prognostic value of Aurora-A expression and suggest that Aurora-A upregulates PFKFB3-mediated glycolysis to enhance ATP supply and promote TC progression. Combining Alisertib with Sorafenib has huge prospects for application in treating advanced thyroid carcinoma.
Polypropylene Anterior-apical single-incision mesh surgery in women with severe pelvic organ prolapse—a case series at 53 months median period follow-up
Authors: Lo Tsia-Shu , Chua Sandy , Shen Yu-Hua , Tan Yiap Loong , Kao Chuan Chi , Hsieh Wu-Chiao 
Published: August 2022

Abstract
Objective
This study aims to assess the medium-term outcomes of UpholdTM-LITE system for treatment of advanced pelvic organ prolapse (POP).
Methods
This is a retrospective case series of 53 months follow-up of 123 consecutive patients who underwent UpholdTM-LITE system. Objective outcome measure was the anatomical correction of prolapse with POP-Q ≤ Stage 1. Subjective outcome was patient’s feedback to questions 2 and 3 of POPDI-6. Secondary outcome measures the quality of life, presence of lower urinary tract symptoms and complications. Quality of life is assessed by validated questionnaires on UDI-6, IIQ-7, POPDI-6, and PISQ-12 at 1 and 3 years post-operatively.
Results
Objective outcome at 1 and 3 years was at 96.7% and 95.4% respectively. The subjective cure was 95.1% and 91.6%. Five-year cumulative cure rate maintained at 87.2%. Secondary outcomes observed improvement on UDI-6, IIQ-7, POPDI-6 and PISQ-12 postoperatively. Bladder outlet obstruction (BOO) improved while De novo urodynamic stress incontinence (USI) increased slightly post surgically. Mesh erosion rate was 0.8%.
Conclusion
The UpholdTM-LITE system demonstrated good medium term anatomical correction of apical and anterior prolapse, with good subjective cure and improved quality of life. Whilst complication rate was low, a slight increased in De novo USI was observed.
Nationwide Survey of Medical Student Interest in and Exposure to Aerospace Medicine
Authors: Thamer Semran , Bello Joseph , Stevanovic Mirjana , Obat Dennis , Buckey Jay 
Published: August 2022

Abstract
INTRODUCTION: Aerospace Medicine is experiencing a renaissance. The field provides physicians with the expertise to promote the health and safety of those traveling in space. Commercial spaceflight is now a reality, meaning that individuals with a variety of medical conditions will be flying in space. NASA has Mars plans and SpaceX plans to send humans to Mars within the next decade, so today’s medical students may be future physicians on these crews. Considering these developments, we evaluated interest in and exposure to Aerospace Medicine among medical students in the United States (US).METHODS: This study was approved by the Dartmouth College Committee for the Protection of Human Subjects and informed consent was obtained by each participant. A 19-question anonymous multiple-choice questionnaire was emailed to current medical students throughout the US. Information about demographics, career and research interests in Aerospace Medicine, opportunities available at students’ respective institutions, and possible avenues for supporting students’ interests was collected and analyzed.RESULTS: 1,244 students (490 men, 751 women, 3 other) with a mean age of 25.8 ± 3.0 years from 61 institutions completed the questionnaire. 1,061 (85.3%) expressed an interest in learning more about Aerospace Medicine if given the opportunity with 208 (16.7%) specifying an interest in research and 939 (75.5%) in career opportunities. 55 (4.4%) indicated that they had access to research opportunities at their institutions while 333 (47.2%) of those who did not, suggested they would pursue research if they had access. 98 (7.9%) of respondents reported that their institution offered an Aerospace Medicine Interest Group or elective. Students from institutions who offered an interest group, elective, or access to research opportunities expressed significantly more interest in Aerospace Medicine careers than those who did not (p<0.0001). 1008 (81.0%) of respondents rated the importance of physician involvement in space exploration as moderately to extremely important.DISCUSSION: Most respondents expressed an interest in learning about Aerospace Medicine during their training. A strong interest in research as well as career opportunities exists despite the majority of students reporting minimal access to opportunities to get involved in the field at most of the surveyed institutions. With growing interest and an expected increase in demand for physicians with a background in Aerospace Medicine, medical schools may be able to support students by increasing access to opportunities.