bluuebunny/crossref_metadata_2025_split huggingface dataset:
B Cells Are Not Involved in the Regulation of Adenoviral TGF-β1– or Bleomycin-Induced Lung Fibrosis in Mice
Authors: Moog Marie T , Hinze Christopher , Bormann Tina , Aschenbrenner Franziska , Knudsen Lars , DeLuca David S , Jonigk Danny , Neubert Lavinia , Welte Tobias , Gauldie Jack , Kolb Martin , Maus Ulrich A 
Published: February 2022

Abstract
Idiopathic pulmonary fibrosis (IPF) is an irreversible, age-related diffuse parenchymal lung disease of poorly defined etiology. Many patients with IPF demonstrate distinctive lymphocytic interstitial infiltrations within remodeled lung tissue with uncertain pathogenetic relevance. Histopathological examination of explant lung tissue of patients with IPF revealed accentuated lymphoplasmacellular accumulations in close vicinity to, or even infiltrating, remodeled lung tissue. Similarly, we found significant accumulations of B cells interfused with T cells within remodeled lung tissue in two murine models of adenoviral TGF-β1 or bleomycin (BLM)-induced lung fibrosis. Such B cell accumulations coincided with significantly increased lung collagen deposition, lung histopathology, and worsened lung function in wild-type (WT) mice. Surprisingly, B cell–deficient µMT knockout mice exhibited similar lung tissue remodeling and worsened lung function upon either AdTGF-β1 or BLM as for WT mice. Comparative transcriptomic profiling of sorted B cells collected from lungs of AdTGF-β1– and BLM-exposed WT mice identified a large set of commonly regulated genes, but with significant enrichment observed for Gene Ontology terms apparently not related to lung fibrogenesis. Collectively, although we observed B cell accumulations in lungs of IPF patients as well as two experimental models of lung fibrosis, comparative profiling of characteristic features of lung fibrosis between WT and B cell–deficient mice did not support a major involvement of B cells in lung fibrogenesis in mice.
Precipitating Factors Leading to Hospitalization and Mortality in Heart Failure Patients
Authors: Shehab Abdulla , Sulaiman Kadhim , Barder Feras , Amin Haitham , Salam Amar M. 
Published: February 2022

Aim:
To investigate the precipitating factors that contribute to hospitalization and mortality in postacute heart failure (AHF) hospitalization in the Middle-East region.

Methods:
We evaluated patient data from the Gulf AHF registry (Gulf CARE), a prospective multicenter study conducted on hospitalized AHF patients in 47 hospitals across seven Middle Eastern Gulf countries in 2012. We performed analysis by adjusting confounders to identify important precipitating factors contributing to rehospitalization and 90- to 120-day follow-up mortality.

Results:
The mean age of the cohort (n = 5005) was 59.3 ± 14.9 years. Acute coronary syndrome (ACS) (27.2%), nonadherence to diet (19.2%), and infection (14.6%) were the most common precipitating factors identified. After adjusting for confounders, patients with AHF precipitated by infection (hazard ratio [HR], 1.40; 95% confidence interval [CI] 1.10–1.78) and ACS (HR-1.23; 95% CI: 0.99-1.52) at admission showed a higher 90-day mortality. Similarly, AHF precipitated by infection (HR-1.13; 95% CI: 0.93–1.37), and nonadherence to diet and medication (HR-1.12; 95% CI: 0.94–1.34) during hospitalization showed a persistently higher risk of 12-month mortality compared with AHF patients without identified precipitants.

Conclusion:
Precipitating factors such as ACS, nonadherence to diet, and medication were frequently identified as factors that influenced frequent hospitalization and mortality. Hence, early detection, management, and monitoring of these prognostic factors in-hospital and postdischarge should be prioritized in optimizing the management of HF in the Gulf region.
Cerebrovascular Events Complicating Cardiac Catheterization - A Tertiary Care Cardiac Centre Experience
Authors: Shivashankarappa Arun B. , Mahadevappa Nagesh C. , Palakshachar Anand , Bhat Prabhavathi , Barthur Ashita , Bangalore Sripal , Chikkaswamy Srinivas B. , Katheria Rockey , Nanjappa Manjunath C. 
Published: February 2022

Background:
Cerebrovascular events (CVEs) are one of the rare complications of cardiac catheterization. This prospective single-center study was conducted to assess the incidence, presentations, and outcomes of CVEs in patients undergoing cardiac catheterization.

Methods:
Patients undergoing cardiac catheterization who developed CVEs within 48 h of procedure were analyzed prospectively with clinical assessment and neuroimaging.

Results:
Out of 55,664 patients, 35 had periprocedural CVEs (0.063%). The incidence of periprocedural CVEs with balloon mitral valvotomy, percutaneous coronary intervention, and coronary angiography was 0.127%, 0.112%, and 0.043%, respectively. A larger proportion of periprocedural CVEs occurred in patients with acute coronary syndrome (ACS, 77.1%) than in patients with stable coronary artery disease (CAD). The majority of CVEs were ischemic type (33 patients, 94.3%). It was most commonly seen in the left middle cerebral artery (MCA) territory. Hemorrhagic CVEs were very rare (2 patients, 5.7%). The majority of the CVEs manifested during or within 24 h of the procedure (31 patients, 88.6%). Neurodeficits persisted during the hospital stay in 20 patients (57.2%), who had longer duration of procedure compared to those with recovered deficits (P = 0.0125). In-hospital mortality occurred in three patients (8.5%) and post-discharge mortality in another 3 (8.5%).

Conclusions:
Periprocedural CVEs are rare and have decreased over time. They occur in a greater proportion in patients with ACS than in patients with stable CAD, more with interventional than diagnostic procedures. Ischemic event in the left MCA territory is the most common manifestation, commonly seen within 24 h of the procedure. Longer duration of procedure was a risk factor for larger infarcts and hence persistent neurodeficit at discharge. Although a substantial number of patients recover the neurodeficits, periprocedural CVEs are associated with adverse outcomes.
A 5 Years Assessment of Patients with Acute Digoxin Poisoning
Authors: Rahimi Mitra , Mahdavinejad Arezou , Shadnia Shahin , Saffaei Ali 
Published: February 2022

Background:
Digoxin poisoning leads to the development of cardiac and noncardiac complications. Digoxin immune fab is a safe and effective antidote, but clinical trials have not been performed in this regard, and most of the evidence is based on prospective studies. Understanding the toxicoepidemiology pattern of digoxin poisoning could provide valuable context for better managing its acute poisoning.

Objectives:
This study aimed to assess the toxicoepidemiology pattern of acute digoxin poisoning through a 5-year assessment in Iran.

Methodology:
In this observational study, the records of 97 patients who were referred with acute digoxin poisoning between 2010 and 2015 were evaluated. Demographic characteristics, past medical history, drug history, chief complaints, vital signs, paraclinical findings, digoxin immune fab administration, and clinical outcomes recorded.

Results:
The mean age of patients was 34.02 ± 17.87 years old. About 24.7% of patients had underlying diseases, and among them, heart failure was the most prevalent disease (29.2%) 42.3% of patients needed intensive care unit (ICU) admission. The mean duration of ICU stay was 4.00 ± 2.29 days. Digoxin immune fab was administered for 4.1% of patients, and an average of 6.2 ± 2.2 vials were used for them. All patients survived, and no mortality was reported.

Conclusions:
Digoxin immune fab administration did not alter the mortality rate. Hence, it can be concluded digoxin immune fab is not appropriate in acute poisoning, but it may be considered in chronic poisoning. Furthermore, acute digoxin poisoning is more common in Iran, and it responds appropriately to conventional treatment.
Minimally-invasive versus open pancreatoduodenectomies with vascular resection
Authors: Yang Edwin , Chong Yvette , Wang Zhongkai , Koh Ye-Xin , Lim Kai-Inn , P. Goh Brian K. 
Published: February 2022

Background:
Minimally invasive pancreatic pancreatoduodenectomy (MIPD) is increasingly adopted worldwide and its potential advantages include reduced hospital stay and decrease pain. However, evidence supporting the role of MIPD for tumours requiring vascular reconstruction remains limited and requires further evaluation. This study aims to investigate the safety and efficacy of MIPD with vascular resection (MIPDV) by performing a 1:1 propensity-score matched (PSM) comparison with open pancreatoduodenectomy with vascular resection (OPDV) based on a single surgeon's experience.

Methods:
This is a retrospective review of 41 patients who underwent PDV between 2011 and 2020 by a single surgeon. After PSM, the comparison was made between 13 MIPDV and 13 OPDV.

Results:
Thirty-six patients underwent venous reconstruction (VR) only and 5 underwent arterial reconstruction of which 4 had concomitant VR. The types of VR included 22 wedge resections with primary repair, 8 segmental resections with primary anastomosis and 11 requiring interposition grafts. Post-operative pancreatic fistula (POPF) occurred in 3 (7.3%) patients. Major complications (>Grade 2) occurred in 16 (39%) patients, of which 7 were due to delayed gastric emptying requiring nasojejunal tube placement. There was 1 (2.4%) 30-day mortality (OPDV). Of the 13 MIPDV, there were 3 (23.1%) open conversions. PSM comparison demonstrated that MIPDV was associated with longer median operative time (720 min vs. 485 min (P = 0.018). There was no statistically significant difference in other key perioperative outcomes such as intra-operative blood loss, overall morbidity, major morbidity rate, POPF and length of stay.

Conclusion:
Our initial experience with the adoption MIPDV has demonstrated it to be safe with comparable outcomes to OPDV despite the longer operation time.
Multi-plant (Phoenix dactylifera and Cyperus esculentus) Effects on Regulating Diet Induced-hypercholesterolemia in Female Sprague-Dawley Rats
Authors: Moses-Otutu Ifueko , Ogeyemhe Blessing , Odigie Efosa 
Published: February 2022

Hypercholesterolemia also known as amplified blood cholesterol represent other forms of hyperlipidemia secondary to atherosclerosis is rising fast in our society. Natural remedies without potential harmful effects are increasing as well. It is against this backdrop that we investigated combined effects of Phoenix dactylifera and Cyperus esculentus against diet induced hypercholesterolemia in rats. In-bred, healthy non-pregnant female Sprague-Dawley rats (11-17weeks, 153-177g) were grouped and orally administered (A1, B1, and C1 =300mg/kg b.w.; A2, B2, and C2 =600mg/kg b.w.; A3, B3, and C3 =900mg/kg b.w.; A4, B4, and C4 =1200mg/kg b.w and D = untreated, n=3) daily for 45days by oral intubation. Polypropylene cages in a sanitized aerated facility, bedded with sawdust housed all animals. They observed 7days adaptation to environmental temperature (25±5ºC), humidity (45±5%), and photoperiod (12:12 hr. day/night). Rats consumed high fat-dietary cholesterol diet to induce hypercholesterolemia and water provided ad libitum. Sera were used for lipid profiling (before, during, and after) following varying treatments plan. Lipid profile: TC (total cholesterol), ST (serum triglycerides), LDLC (low-density lipoprotein cholesterol), HDLC (high-density lipoprotein cholesterol) were abnormal in pre-experimental phases (both test and control). Values were regulated after treatment particularly in 1200mg/kg b.w in rats administered P. dactylifera: TC50.17±2.7/dL, ST27.7±0.6mg/dL, LDL23.2±2.5mg/dL, HDL89.1 ± 3.9/dL; C. esculentus: TC41.03±2.3mg/dL, ST27.4±2.9mg/dL, LDL27.1±1.3mg/dL, HDL94.3±1.8mg/dL; and mix: TC32.77±3.8mg/dL, ST23.5±2.4mg/dL, LDL21.3±2.9mg/dL, HDL97.8±3.9mg/dL excluding control: TC92.62±0.3mg/dL, ST71.3±1.9mg/dL, LDL64.0±0.2mg/dL, and HDL21.3±1.1mg/dL (p < 0.05). Therefore, synergy of P. dactylifera and C. esculentus regulate hypercholesterolemia in rats while C. esculentus particularly is the super active constituent in the mix.
Keywords: C. esculentus; P. dactylifera; lipid profile; hyperlipidemia; medicinal crops; experimental rats
Solving Mixed Boundary Value Problems using Fourier Transform and Dual Integral Equations Method
Authors: Umar Abubakar , Maishanu Zilkarnaini 
Published: February 2022

The research considered the solution of the system of dual integral equations involving Fourier transform occurring in mixed boundary value problems for Laplace’s equation with mixed Dirichlet-Neumann boundary conditions. The dual integral equations involving trigonometric function kernel have been solved using Fourier sine transforms. Graphical solutions with the help of Mathematica were used to demonstrate the effectiveness of this method.
Keywords: Boundary value problem; Laplace’s equation; Mixed boundary value problems; Fourier transform; Dual integral equations.
Analysis Of Human Resource Competency, Internal Control System, Quality Of Financial Statements and Application Of Government Accounting Standards To Accountability Of Performance Of Government Agencies In Pegunungan Bintang Regency
Authors: Ramasoyan Ramasoyan , Van Sweet Sesa Pascalina , Patma Kurniawan , Larasati Rudiawie 
Published: February 2022

Regional device organization (OPD) of Pegunungan Bintang Regency. The internal control system has a significant effect on the accountability of the performance of government agencies in the Purpose Organization in this study to know and analyze the influence of human resource competence, the influence of internal control systems influence the quality of financial statements, the implementation of government accounting standards on government performance accountability,and silmultan to the accountability of government agencies performance. The population in this study is employees of the Regional Device Organization (OPD) Of Pegunungan Bintang District who routinely carry out inspection tasks and have a minimum educational background diploma 3 (D3) Accounting, have attended JFA training (Auditor Functional Department) and have a minimum work experience of 1 Year. The analysis techniques used are multiple regression analysis techniques to process and discuss the data that has been obtained and test the proposed hypothesis. The results of the analysis are known that human resources competency variables have a significant influence on the accountability of the performance of government agencies Regional Devices (OPD) Gunung Bintang District,the quality of financial statements have a significant effect on the accountability of the performance of government agencies in the Regional Device Organization (OPD) Gunung Bintang District.
Itinerary of children in the management of intussusception: the true reasons of delayed medical care in a west African country
Authors: Boume Missoki Azanlédji , Bikor Kwami Edem Edoh , Donou Amivi Alice , Akakpo-Numado Gamedzi Komlatsè 
Published: February 2022

Background: The delayed medical care of intussusception is still the reason for morbidity and mortality in many developing countries. The objective of this study is to take stock of the itinerary of children treated for intussusception, in order to to reduce the delay of the treatment.
Methods: This is a cross-sectional study, carried over three years (from 1st June 2016 to 31 May 2019), at a Paediatric Surgery department of Campus Teaching Hospital in Lomé (Togo). The medical record of 23 children whose median age was 12 months, were included. Symptoms, the average time before the first consultation, different health centres consulted and treatment received, and the average time before the admission in the specialised department were studied.
Results: In three years, 23 children were managed for intussusception. The average time before the first consultation from home in a health centre was 1.87 days. No patient was admitted to the Paediatric Surgery department directly from home. Twelve patients consulted one centre, eight patients 2 centres, and one patient 3 centres before admission. Before referral, these patients were misdiagnosis as gastro-enteritis in 8 cases (38.10%), malaria in 8 cases (38.10%), and digestive salmonellosis in 3 cases (14.29%). The time elapsed between the beginning of the disease and the admission in specialised service was on average 5.39 days and 3.52 days elapsed then between the first consultation from home and the admission to the Paediatric Surgery service.
Conclusion: Valuable time to manage intussusceptions is lost in other medical health services before admission to specialised services. Action on this route will have to be taken through an effective counter-referral system.
La evaluación formativa en la educación superior
Authors: Veronica Bazán Linares Magda , De la Cruz Lauriano Antonio Zavaleta , Rojas Oscar Melanio Dávila , Jiménez José Ángel Meneses , Oyola Mabel Cruz Palma 
Published: February 2022

La evaluación es desde siempre un importante mecanismo de valoración de los aprendizajes en los procesos académicos. Este artículo asumió el objetivo analizar la importancia de la valuación formativa en la educación superior. La investigación siguió el paradigma interpretativo, enfoque cualitativo, documental y explicativo. Para lo cual se realizó una exploración sobre el estado del arte de diferentes artículos científicos sobre la valoración formativa en la educación superior. Una exploración de la importancia de los instrumentos y herramientas que apoyan esta valoración, su predominio en la consecución de las competencias profesionales en los jóvenes universitarios. Se revisaron treinta y cuatro documentos alojados en revistas como Scopus, Wep of Science, Sciencedierct, Scielo, Redalyc, Dialnet y ScienceDirect, manejando discernimientos de elección y excepción. Se percibió que la valoración formativa y sus instrumentos deben formar parte del sistema de evaluación universitaria. Se concluyó, que interviene en el fortalecimiento de la participación colaborativa, el intercambio de información promueve su participación crítica de los estudiantes. La rúbrica, el portafolio, la retroalimentación favorecen la autoevaluación, autoformación y el constante estudio. Jóvenes empoderados y más seguros al momento de sus participaciones y esto se refleja en la mejora de las competencias profesionales.
ANALISIS RASIO KEUANGAN TERHADAP PERUBAHAN LABA PADA PERUSAHAAN FARMASI
Authors: Sarirati Putri , Melani Dewi 
Published: February 2022

The purpose of this study is to determine the effect of the company's financial ratio empirically, both partially and simultaneously on changes in profit. The selection of samples was conducted by purposive sampling method from 12 company samples obtained by 9 company samples. The study used data analysis methods with multiple linear regressions and performed classical assumption tests first.The results of this study showed that the Current Ratio variable partially had an influence and negatively on the change in profit. Based on the resultsof the t test witha t count of -3,341 fromthetable's t value of -2,030 and a significance level of 0.002 0.05. The Return on Assets variable partially has an effect and positives on the change in profit. Based on the resultsof the t test with at calculate of 12,978 ofthetable's t value of 2,030 and the significance level of 0.000 0.05. While the Debt to Equity Ratio variable and the Total Assets Turnover variable partially had no significant effect on the change in profit. Simultaneous testing showed that variables Current Ratio, Return On Assets, Debt to Equity Ratio,and Total Assets Turnover simultaneously had a significant effect on changes in profits. Based on the results of the test F with a significance value of 0.000 0.05 and Fcalculated 46.745 from the table Fvalueof 2.61. The variable influence rate of Current Ratio, Return On Assets, Debt to Equity Ratio and Total Assets Turnover simultaneously is 82.4%.
Comparison of In-game External Load Metrics Among Positions and Between Halves for Division I Collegiate Women’s Lacrosse Athletes
Authors: Kilian Justin , Snyman Kristen , Miyashita Theresa 
Published: February 2022

External load has become a common metric for coaches to track the activity profiles of athletes during training and competition. The advent of wearable technology has made external load monitoring accessible for more coaches. The purpose of this study was to compare positional (attack, midfield, and defense) and game (first half to second) external loads. An NCAA Division I women’s lacrosse team was recruited to wear triaxal accelerometers and GPS units during five non-conference games during the 2020 regular season. The external load metrics evaluated for this study included total distance, sprint distance (> 19 km∙hr-1), number of power plays (> 3 m·s-2), top speed, and PlayerLoad. Significance was set at p < 0.05. No significant differences among positions were observed for full game measures (p > 0.05). A significant main effect for time was observed for sprint distance (midfield; p < 0.001 ) and power plays (midfield; p < 0.001 and defense; p = 0.004). While no significant differences occurred for activity profiles among positions, high-intensity efforts (sprint distance and power plays) were significantly less in the second half, likely due to fatigue. Coaches and sports scientists can use this information to manage in-game fatigue through tactics such as strategic substitutions and time-outs, thus preserving the intensity of the activity profiles late in the game.
Meningkatkan Pengetahuan Siswa Tentang Jajanan Sehat
Authors: Putri Mega Arianti , Yuliana Fitria 
Published: February 2022

Pertumbuhan dan perkembangan anak usia sekolah harus optimal seperti pemberian nutrisi dengan kualitas dan kuantitas yang baik serta benar, bila tidak benar dapat mengakibatkan gangguan pada banyak organ tubuh anak usia sekolah. Memasuki usia sekolah, anak mulai ingin menunjukkan kemampuannya menentukan pilihan atas makanan. Cara yang dapat dilakukan adalah dengan promosi kesehatan mengenai jajanan sehat dan bahaya junk food. Kegiatan pengabdian kepada masyarakat ini dimaksudkan kepada siswa untuk mengurangi paparan anak sekolah terhadap makanan jajanan yang tidak sehat dan tidak aman. Kegiatan pengabdian ini dilaksanakan dengan metode sebagai berikut: a).Metode ceramah, digunakan untuk menyampaikan pengetahuan tentang jajanan sehat dan bergizi meliputi: Unsur gizi dalam makanan dan bahan tambahan makanan. b). Metode praktek, digunakan untuk simulasi membandingkan 2 macam jajanan yang biasa dikonsumsi,secara berkelompok dengan setiap kelompok beranggotakan 5 orang anak. c).Metode tanya jawab, digunakan untuk memberikan tanggapan kepada siswa sekaligus untuk mendapatkan tanggapan siswa tentang materi yang telah disampaikan selama kegiatan. Antusias siswa pada saat pelaksanaan penyuluhan sangat tinggi, dibuktikan dengan semua siswa mengerjakan pretes. Pada saat proses penyampaian materi, siswa juga bisa diajak interaksi, dengan mengajukan beberapa pertanyaan dari materi yang telah disampaikan. Hasil pretes rata-rata sebesar 77,68 dan rata-rata postes sebesar 85,69. Hasil penghitungan nilai menunjukkan pengetahuan jajanan sehat siswa meningkat dengan kategori sedang. Siswa dapat membedakan jenis makanan sehat dan tidak sehat serta mengetahui dampak dari jajanan sehat setelah dikonsumsi. Kesimpulan dari kegiatan ini adalah: (1) Antusias siswa sangat tinggi, semua siswa mengikuti kegiatan mulai dari awal sampai akhir; (2) Pengetahuan siswa tentang jajanan sehat meningkat. Saran dari kegiatan pengabdian ini adalah pengabdian ini dapat dilakukan di sekolah lain dengan melibatkan guru serta orang tua, agar pengawsan nutrisi yang didapatkan anak bisa lebih baik.