bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency and mechanism of phosphorus removal by iron-organic matter associations in peatland
Authors: Yang weilin , Xiang Wu , Bao Zhengyu , Huang Chunlei , Ma Ming , Lu Xinzhe , Yao Lingyang , Wang Yong 
Published: March 2022

Abstract
This study was carried out to evaluate the efficiency and mechanism of P removal by different types of Fe-OM associations in peatlands. Humic substance (HS) and particulate organic matter (POM) were isolated from peat soils, and different types of iron-organic matter associations (Fe-HS and Fe-POM) were prepared. In addition, the natural combination of Fe3+ with peat was simulated. Then, isothermal adsorption experiments were carried out on the synthesized Fe-OM and iron-contained peat soils. All the adsorption data can be well fitted by the Langmuir adsorption model. The theoretical maximum adsorption capacity (Qmax) of Fe-HS associations can reach 36.90 mg/g, which is approximately two times higher than that of ferrihydrite (19.23 mg/g) and ten times higher than that of hematite (3.26 mg/g) and goethite (2.08 mg/g). The adsorption capacities of peat soils and POM were significantly enhanced by combinations with exogenous Fe3+. The Qmax of the original peat and iron-contained peat were 2.83 mg/g and 7.36 mg/g, respectively, and those of the original POM and Fe-POM association were 4.31 mg/g and 5.89 mg/g, respectively. The contribution of Fe-OM associations to phosphorus removal in peatlands is much higher than that of inorganic iron oxide. In addition, exogenous Fe3+ could also participate in other phosphorus removal processes.
Serum creatinine / cystatin C ratio is a surrogate marker for sarcopenia in patients with idiopathic pulmonary fibrosis
Authors: Fujita Kohei , Ohkubo Hirotsugu , Nakano Akiko , Takeda Norihisa , Fukumitsu Kensuke , Fukuda Satoshi , Kanemitsu Yoshihiro , Uemura Takehiro , Tajiri Tomoko , Maeno Ken , Ito Yutaka , Oguri Tetsuya , Ozawa Yoshiyuki , Murase Takayuki , Niimi Akio 
Published: March 2022

Abstract
Background
The serum creatinine / cystatin C (Cr/CysC) ratio has attracted attention as a marker for sarcopenia, but has not been studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to confirm the utility of the serum Cr/CysC ratio in predicting sarcopenia and to investigate its clinical relevance.
Methods
This cross-sectional pilot study prospectively enrolled patients with stable IPF. IPF was diagnosed through multidisciplinary discussions according to the 2018 international guidelines, and sarcopenia was diagnosed according to the 2019 consensus report of the Asian Working Group for Sarcopenia. Patient-reported outcomes (PROs) were evaluated using the modified Medical Research Council (mMRC) dyspnea scale, chronic obstructive pulmonary disease assessment test (CAT), and King’s Brief Interstitial Lung Disease (K-BILD) questionnaire. The associations between serum Cr/CysC ratio and the presence of sarcopenia and other clinical parameters, including PROs scores, were examined.
Results
A total of 49 Japanese patients with IPF with a mean age of 73.0 ± 7.7 years and a percent predicted forced vital capacity of 80.4 ± 15.5%, were enrolled. Sarcopenia was diagnosed in 18 patients (36.7%), and the serum Cre/CysC ratio was 0.86 [0.76–0.94] (median [interquartile range]). Receiver operating characteristic curve analyses for detection of sarcopenia according to the serum Cr/CysC showed that the area under the curve, optimal cutoff value, specificity, and sensitivity were 0.85, 0.88, 0.65, and 0.94, respectively. Sarcopenia was identified in 13% of patients with a high serum Cr/CysC ratio (≥ 0.88) and 60% with a low serum Cr/CysC ratio (< 0.88) (P < 0.001). Multiple linear regression analysis showed that the serum Cr/CysC ratio was an independent predictive marker of worse PROs evaluated using mMRC (P < 0.05), CAT (P < 0.05), and K-BILD (P < 0.05).
Conclusions
This study showed that the serum Cr/CysC ratio can be used as a surrogate marker of sarcopenia in patients with IPF. Furthermore, it is important to pay attention to the serum Cr/CysC ratio because a lower serum Cr/CysC ratio is associated with worse PROs.
Design of an untethered magbot: mimicking fruit fly larvae using magnetothermal actuation
Authors: Ding Jianning , Xu Lin , Liu Siyuan , Wagner Robert , He Qingrui , Zou Xiang , Fu Yu , Shi Xingling , Zhao Dongliang , Vernerey Franck 
Published: March 2022

Abstract
Soft, worm-like robots show promise in complex and constrained environments due to their robust, yet simple movement patterns. Although many such robots have been developed, they either rely on tethered power supplies and complex designs or cannot move external loads. To address these issues, we here introduce a novel “magbot” that utilizes temperature-sensitive actuation and surface pattern-induced anisotropic friction to achieve peristaltic locomotion inspired by fly larvae. This simple, untethered design can carry cargo that weighs up to three times its own weight with only a 17% reduction in speed over unloaded conditions thereby demonstrating, for the first time, how soft, untethered robots may be used to carry loads in controlled environments. Given their small scale and low cost, we expect that these magbots may be used in remote, confined spaces for small objects handling or as components in more complex designs.
Nanocrystalline Cellulose Based on Chitosan Hydrogel Structure as a Biological Adsorbent for Effluent of Fish Culture Farms
Authors: Darabitabar Fatemeh , yavari vahid , Hedayati Aliakbar , Zakeri Mohammad , Yousefi Hossein 
Published: March 2022

Abstract
Natural hydrogels have replaced synthetic hydrogels due to their properties such as long life, high water absorption capacity, high strength and resistance. Recently, hydrogels have been defined as two- or multi-component systems consisting of three-dimensional networks of polymer chains that fill the space between macromolecules, and the efficiency of their water absorption depends on the polymeric nature and density of the polymer network connections. Due to climate change and frequent droughts, supply of fresh water has become one of the major barriers of sustainable aquaculture development in Iran. Therefore, wastewater treatment and reuse can be a suitable solution to meet the water requirement of expanding aquaculture industry. The purpose of the present study is to assess the efficiency of a new hydrogel prepared from agricultural waste (bagasse) in removal of nitrogen and phosphate compounds from the effluent of fish farms. First, the hydrogel was prepared during the polymerization process and then, in order to determine the optimal adsorption, it was tested in a discontinuous system by performing adsorption isotherm calculations. In cellulose/chitosan nanocrystalline hydrogel nanosorbent, the removal rates for nitrate, nitrite and phosphate were 84.3, 86 and 90.9%, respectively. Optimal adsorption were determined at acidity 6, time 30 minutes, temperature 40 ° C, concentration 100 mg / l and adsorbent weight 0.5 g. Comparison of adsorption isotherm models showed more conformity with Freundlich and Tamkin absorption models with correlation coefficients of 0.99 and 0.97 for nitrate, 0.98 and 0.91 for nitrite and 0.99 and 0.93 for phosphate, respectively.
Postoperative Complications following Lumpectomy and Mastectomy in Women with Pregnancy Associated Breast Cancer
Authors: Chichura Anna , ElSherif Ayat , Yao Meng , Kollikonda Swapna , Risal Djohan , Valente Stephanie , AlHilli Zahraa 
Published: March 2022

Abstract
Purpose: This study aimed to delineate postoperative complications following lumpectomy and mastectomy in women with pregnancy associated breast cancer (PABC).Methods: This is a single institution retrospective study of 74 patients with PABC treated with lumpectomy (n=28) or mastectomy (n=46). Patient demographics, presentation, tumor characteristics, staging, genetic testing, and postoperative complications were recorded. Results: PABC was diagnosed in 74 patients; 28 (37.8%) were diagnosed with PABC during pregnancy (PABC-P) and 46 patients (62.2%) were diagnosed with postpartum PABC within the first 12 months after delivery (PABC-PP). The overall clinical stage distribution at diagnosis was: Stage 0, 6.9%; I, 18.1%; II, 47.2%; III, 22.2%; and IV, 5.6%, with no significant difference between PABC-P and PABC-PP (p=0.18). There was no significant difference in the rate of lumpectomy (25.0% vs 23.9%, p=0.92), mastectomy (75.0% vs 76.1%, p=0.92), sentinel lymph node biopsy (39.3% vs 52.2%, p=0.28), axillary dissection (14.3% vs 4.3%, p=0.19), or rate of immediate reconstruction (42.9% vs 65.7%, p = 0.094) performed in patients with PABC-P and PABC-PP, respectively. Contralateral prophylactic surgery was performed in 43.2% of patients (39.3% PABC-P vs 47.5% PABC-PP, p=0.59). Most (79.9%) patients did not experience any postoperative complications, regardless of whether they underwent lumpectomy or mastectomy (83.3% vs 78.6%, p=0.99) or if they had PABC-P or PABC-PP (89.3% vs 73.9%, p=0.11). There was a statistically significant difference in the rate of complications between PABC-P patients undergoing mastectomy with immediate reconstruction (n=0/9, 0%) as compared to the PABC-PP patients (n=9, 39%; p=0.035). Seroma was the most commonly observed complication after both lumpectomy and mastectomy (n=3 vs n=5, p=0.39). Conclusions: There was no increased risk of postoperative complications in women with PABC treated with lumpectomy as compared to mastectomy. There is an increased risk of postoperative complications in patients with PABC-PP treated with mastectomy and immediate reconstruction.
Fast and efficient Pre-Trip health examination using pulsogram
Authors: Dzyuba Evgeny , Shlipakov Sergey , Gutor Ekaterina , Zhidkova Elena , Gurevich Marina , Rudnikova Natalia , Pankova Vera , Vilk Mikhail , Gurevich Konstantin , Zaborova Victoria , Drapkina Oksana 
Published: March 2022

Abstract
Relevance: The train drivers are responsible for the safety of transported people and goods. Therefore, medical monitoring of their state of health is an integral part of ensuring the safety of railway traffic.Purpose: to study the possibilities of using a pulsogram for analyzing the parameters of heart rate variability during pre-trip health examination of members of train crews.Materials and methods: 183 male train crew members (106 engine train drivers, 77 train drivers’ assistants) were examined; the average age was 37.7 ± 9.4 years. ECG and pulsogram were measured simultaneously, and heart rate variability was analyzed.Results: A high degree of coincidence of mean values and variances of heart rate variability parameters, calculated on the basis of ECG (electrocardiogram) and pulsogram, was found. A high degree of reliable positive correlation was established between these parameters. Significant differences in the parameters of heart rate variability were revealed between the members of train crews who underwent and those who did not undergo the first-time pre-trip medical examination.Conclusion: Measurements of heart rate variability parameters based on the pulsogram can be used to solve a number of urgent problems of pre-trip medical examination of members of train crews.
Potential of Rice (Oryza Sativa L.) Cultivars to Mitigate Methane Emissions from Irrigated Systems in Latin America and the Caribbean
Authors: SOREMI Paul Abayomi Sobowale , Chirinda Ngonidzashe , Graterol Eduardo , Alvarez Maria F. 
Published: March 2022

Abstract
Irrigated rice, represents a methane (CH4) emissions source. In rice fields, the dominance of plant-mediated transportation of CH4 from submerged soils to the atmosphere raises the possibility of varietal differences in CH4 emissions. Previous findings remain inconclusive and no study has explored varietal differences in CH4 emissions of rice in Latin America. A field experiment was conducted in Colombia to investigate the potential of a breeding line, a commercial variety, and two rice hybrids to mitigate CH4 emissions from irrigated rice. Data on CH4 emissions, phenotypic, physiological, root traits, and grain yield were collected. Results showed CH4 emissions, grain yield, root length and root surface area differences followed the order Hybrid 2 > Hybrid 1 > breeding line > Commercial variety. Whereas CH4 emissions per unit area for the two rice hybrids were within the of range 29–62% higher than the commercial variety and breeding line, CH4 emission per unit grain yield were similar across the rice genotypes. Our data suggests that differences in root development and grain yields explain genetic influence on CH4 emissions. We conclude that by exploiting differences in productivity and root characteristics among rice cultivars the transition towards low emission rice production systems can be accelerated.
The Application Of Remodeled Glove Puppetry For Children With Developmental Disabilities
Authors: Lai Chia Ching , Hsieh Hsieh-Chun , Chen Hsin-Yung , Lin Chien-Heng 
Published: March 2022

Abstract
Objective: To study the improvement of hand performance and play behavior in children with developmental disabilities using remodeled glove puppetry. Method: A pretest-posttest design was used in this randomized controlled trial to evaluate the intervention. Sixty-two children with developmental disabilities were randomly divided into experimental and control groups (n=31 each). Both groups underwent puppet play sessions once daily in playrooms. The children in the experimental group underwent rehabilitation by playing with the remodeled glove puppetry for 12 weeks, while the children in the control group played with non-remodeled glove puppetry. The Chinese puppet was remodeled using the Lego EV3® robot. We analyzed the motion kinematics of the hand using Siliconcoach® Pro 7 software and measured the force produced by the Baseline® hydraulic pinch gauge. The revised Knox Preschool Play Scale was used to score the play behavior. Results: Improvement in hand kinematics and play scales in the experimental group indicated that glove puppetry remodeled with EV3® robots had a good training effect. Discussion: Remodeled glove puppetry improved the range of motion and the qualities of play behavior, such as material management and participation of play quality. Further studies using remodeled glove puppetry with different disability populations are needed.
CD36 accelerates the progression of hepatocellular carcinoma by promoting FAs absorption
Authors: Tao Lide , Ding Xiangmin , Yan Lele , Xu Guangcai , Zhang Peijian , Ji Anlai , Zhang Lihong 
Published: March 2022

Abstract
Background: CD36 is emerging as a potential strategy for cancer treatment because of its function of regulating fatty acid intake. The purpose of this study was to clarify the molecular mechanism of CD36 in the progression of HCC.Methods: TCGA database was used to analyze the relationship of CD36 with HCC. The expression of CD36 in HCC clinical samples and cell lines was detected by qRT-PCR and western blot. Huh7 cells and HCCLM3 cells were transfected and treated into different group. CCK-8 and clone formation assay were used to detect the cell proliferation ability. Wound healing and transwell experiment were used to detect the metastatic ability. HCC xenografts were constructed in nude mice by subcutaneous injection of stably transfected Huh7 cells. The expression of CD36 in HCC was detected by immunohistochemistry (IHC). The contents of phospholipids and triglycerides in HCC cells were detected by ELISA. And the content of neutral lipids in HCC cells was detected by staining with BODIPY 493/503 and DAPI dye. Then transcriptional sequencing was used to determine the downstream mechanism of CD36 in HCC, and the differentially expressed genes (DEGs) were analyzed. Results: CD36 was up regulated in HCC. Knockdown of CD36 could suppress the proliferation and metastasis of HCC in vitro and in vivo by regulating FAs intake in HCC. In addition, the expression of AKR1C2 was suppressed by sh-CD36, and which was also involved in the regulation of FAs intake.Conclusion: The molecular mechanism by which CD36 accelerated the progression of HCC was to promote the expression of AKR1C2 and thus enhance fatty acids (FAs) intake.
Design of High-Sensitivity Surface Plasmon Resonance Sensor Based on Nanostructured Thin Films for Effective Detection of DNA Hybridization
Authors: Ghayoor Reza , Zangenehzadeh Soraya , Keshavarz Alireza 
Published: March 2022

Abstract
With the increasing ability to control infectious diseases in developed countries, there has come the realization that genetic diseases are a major cause of disability, death, and human tragedy. Recently, Coronavirus as an epidemic, has spread worldwide and the ability to identify low concentrations and the mutations of the virus can effectively reduce the spread of the disease. In this paper, A surface plasmon resonance sensor based on nanostructured thin films and graphene as a 2D material has been designed with high sensitivity and accuracy to identify DNAbased infectious diseases such as SARS-CoV-2. The effects of different structural factors, including nanolayers thickness on the sensor’s performance are assessed through the transfer matrix method. The results demonstrated that the sensor with the Kretschmann configuration has ultra-high sensitivity (192.19 deg/RIU) and a high figure of merit (634.68 RIU -1 ).
Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei
Authors: Erenler Ramazan , Yildiz Ilyas , Aydin Ali , Genc Nusret 
Published: March 2022

Abstract
Onosma species have been used commonly for traditional medicine for years due to their bioactive compounds content. Onosma bourgaei aerial part was extracted with hexane and methanol successively. The methanol extract was subjected to chromatographic techniques to isolate allantoin (1), 3,4-dihydroxybenzaldehyde (2), luteolin-7-O-glucoside (3), apigenin-7-O-β-glucoside (4), diosmetin-7-O-β-glucoside (5), rosmarinic acid (6), globoidnan A (7). The structure of isolated compounds were identified by spectroscopic techniques such as 1D-NMR, 2D-NMR, FTIR, and LC-TOF/MS/MS. Antiproliferative activity of extract and natural compounds were carried out using HeLa (human epithelial cervix adenocarcinoma, ATCC® CCL-2™), HT-29 (human colorectal adenocarcinoma, ATCC® HTB38™), MCF-7 (human mammary gland adenocarcinoma, ATCC® HTB22™) and A549 (human lung carcinoma, ATCC® CCL185™) cancerous cells and normal cells, FL (human epithelial amnion cell, ATCC® CCL62™). Lactate dehydrogenase (LDH) was performed for cytotoxicity. The compounds, 4, 6, and 7 displayed the strong antiproliferative activity against corresponding cell lines. Apigenin-7-O-β-glucoside (4) revealed the excellent activity on HeLa, HT29, A549, MCF6 cancer cell lines with the values of (IC50, µM) 167.3, 196.8 181.1, 203.5 respectively compared standard compound, cisplatin.
Effect of multiple washing operations on removal of heavy metals from an alkaline farmland soil and the strategy for agricultural reuse
Authors: Guo Xiaofang , Gao Yu , Han Wei , Zhao Guohui , Zhang Guixiang , Liu Dandan 
Published: March 2022

Abstract
Little study carried out the soil washing experiments using pot experiments to simulate in-situ soil washing operation, particularly for the alkaline soil. This study explored the effect of multiple washing operation using pot experiments on the removal efficiencies of heavy metals from the alkaline farmland soil and the reuse strategy of the washed soil for safe agricultural production. The results showed that the removal efficiencies of Cd, Pb, Cu and Zn after the seven times washing with the mixed chelator (EDTA, GLDA and citric acid) were 41.1%, 47.1%, 14.7% and 26.5%, respectively, which were close to those from the results of EDTA treatment. For the alkaline soil studied, the 2nd washing with the mixed chelator most effectively removed heavy metals owing to the activation of heavy metals after the first washing operation. The mixed chelator more effectively increased the proportion of stable speciation of heavy metals and maintained soil nutrients such as nitrogen content in soil than EDTA did, indicating the little disturbance of alkaline soil quality after being washed by the mixed chelator. After application of amendment into the washed soil, there was no visible difference in biomass weight of crops from the soil washed with different agents, indicating that the inhibitory effect of both washing agents on the plant growth was effectively alleviated. The Cd and Pb in Z. may were below the threshold of Hygienical Standard for Feeds of China (GB 13078 − 2017) (1 and 30 mg·kg− 1). Moreover, after three times of cropping, the concentrations of available heavy metals in the soil washed with the mixed chelator were lower than those in the washed soil with EDTA, indicating the value and potential of agricultural reuse of alkaline farmland soil being washed with the mixed chelator here.
Clinical characteristics and prognosis of Primary biliary cholangitis with esophagogastric varices.
Authors: Zhang Mingyue , Xie Huan , Gerussi Alessio , Han Lin , Chen Ying , Zhao Jun , Liang Qingsheng , Li Baosen , Invernizzi Pietro , Zou Zhengsheng , Gershwin ME , Sun Ying 
Published: March 2022

Abstract
Background and aims The development of esophagogastric varices (EGV) is one of the most common complications in patients with Primary biliary cholangitis (PBC); yet, factors associated with their development have been poorly characterized. In this cohort, we aimed to investigate the clinical factors associated with EGV in patients with PBC. Methods: The cohort study included patients with PBC who received esophagogastroduodenoscopy screening and ursodeoxycholic acid (UDCA) therapy at baseline. Liver-related death and liver transplantation were assessed as the endpoint, liver transplantation-free survival rates were estimated by using Kaplan–Meier methods, and Cox regression analysis was performed to identify the potential risk factors of endpoint events for PBC with EGV. Results The 690 patients included in this study had a mean age of 57 years old and 553 (80.1%) were females, 13 (7.9%) in the 165 PBC with no liver cirrhosis and 400 (76.2%) in the 525 PBC with liver cirrhosis had signs of EGV, and 215 (31.2%) patients of the cohort had bleeding esophagogastric varices as the first presentation at diagnosis. The median (Interquartile range) follow-up period was 4.0 (2.0, 6.0) years. During the follow-up duration, 99 patients progressed to liver-related deaths, and 23 patients underwent liver transplantation. The 5-year cumulative LT-free survival was 88.20% (95% CI 83.7-92.7) in PBC without EGV, and 80.90% (95% CI 80.0-89.9), 80.30% (95% CI 69.7-90.9), 75.70% (95% CI 68.3-83.1) among PBC with small, medium and large-sized esophageal varices at baseline, respectively (p =0.002). The 10-year cumulative LT-free survival was 68.8% (95% CI 53.9-82.8) in PBC without EGV, and 54.2% (95% CI 36.4-72.0), 51.6% (95% CI 29.9-73.3), 62.1% (95% CI 49.2-75.0) among PBC patients with small, medium and large-sized esophageal varices at baseline, respectively (p=0.001). History of endoscopic therapy and UDCA biochemical responder with Paris criteria for PBC with EGV were associated with a statistically significant reduced risk of LT or death (p =0.001 and p=0.007).Conclusions Endoscopic therapy and a favorable biochemical profile of UDCA can prolong the LT-free survival of PBC patients with EGV, despite the presence of large-sized esophageal varices.