bluuebunny/crossref_metadata_2025_split huggingface dataset:
GSH‐Responsive Organosilica Hybrid Nanosystem as a Cascade Promoter for Enhanced Starvation and Chemodynamic Therapy
Authors: Wu Huan , Li Xianglong , Liu Shi , Wang Qinghua , Cao Yuanyuan , Hao Ji‐Na , Li Yongsheng 
Published: October 2022

AbstractGlucose oxidase (GOD)‐mediated starvation therapy (ST) that causes intratumoral glucose depletion is a promising strategy for tumor treatment. However, the ultimate efficacy is inevitably limited by tumor hypoxia, as oxygen is a key component in the consumption of glucose by GOD. In this study, a kind of glutathione (GSH)‐responsive organosilica hybrid micelles loaded with Mn3O4 and GOD (denoted as Mn3O4@PDOMs‐GOD) is ingeniously designed for enhanced ST and chemodynamic therapy (CDT). Specifically, the internalized Mn3O4@PDOMs‐GOD in tumor cells consumes intracellular glucose and oxygen (O2) under the catalysis of GOD to generate hydrogen peroxide (H2O2), which is subsequently decomposed by Mn3O4 to liberate O2. This cyclically regenerated O2 will form a virtuous cycle of O2 and H2O2 compensation to enhance the ST outcome. Meanwhile, Mn3O4 can oxidize and deplete the overexpressed GSH in the tumor microenvironment (TME) to release Mn2+, which then catalyzes H2O2 into highly toxic hydroxyl radicals (·OH) to accomplish chemodynamic therapy (CDT). Both in vitro and in vivo experiment results demonstrate the significant antitumor efficacy of Mn3O4@PDOMs‐GOD by the cooperatively enhanced ST and CDT, suggesting the feasibility to develop promising therapeutic platforms with higher treatment efficacies.
A Bioinspired Retinomorphic Device for Spontaneous Chromatic Adaptation
Authors: Tan Yinlong , Hao Hao , Chen Yabo , Kang Yan , Xu Tao , Li Cheng , Xie Xiangnan , Jiang Tian 
Published: October 2022

AbstractChromatic adaptation refers to the sensing and preprocessing of the spectral composition of incident light on the retina, and it is important for color‐image recognition. It is challenging to apply sensing, memory, and processing functions to color images via the same physical process using the complementary metal–oxide–semiconductor technology because of redundant data detection, complicated signal conversion processes, and the requirement for additional memory modules. Inspired by the highly efficient chromatic adaptation of the human retina, a 2D oxygen‐mediated platinum diselenide (PtSe2) device is presented to simultaneously apply sensing, memory, and processing functions to color images. The device exhibits a wavelength‐dependent bipolar photoresponse and the linear pulse‐number dependence of photoconductivity, which is dominated by the photon‐mediated physical adsorption and desorption of oxygen molecules on bilayer PtSe2. The proposed retinomorphic device shows superior image classification accuracy (over 90%) compared to an independent pseudocolor channel (less than 75%). Hence, it is promising for developing artificial vision perception systems with reduced architectural complexity.
A Monolithic Graphene‐Functionalized Microlaser for Multispecies Gas Detection
Authors: Guo Yanhong , Li Zhaoyu , An Ning , Guo Yongzheng , Wang Yuchen , Yuan Yusen , Zhang Hao , Tan Teng , Wu Caihao , Peng Bo , Soavi Giancarlo , Rao Yunjiang , Yao Baicheng 
Published: October 2022

AbstractOptical‐microcavity‐enhanced light–matter interaction offers a powerful tool to develop fast and precise sensing techniques, spurring applications in the detection of biochemical targets ranging from cells, nanoparticles, and large molecules. However, the intrinsic inertness of such pristine microresonators limits their spread in new fields such as gas detection. Here, a functionalized microlaser sensor is realized by depositing graphene in an erbium‐doped over‐modal microsphere. By using a 980 nm pump, multiple laser lines excited in different mode families of the microresonator are co‐generated in a single device. The interference between these splitting mode lasers produce beat notes in the electrical domain (0.2–1.1 MHz) with sub‐kHz accuracy, thanks to the graphene‐induced intracavity backward scattering. This allows for lab‐free multispecies gas identification from a mixture, and ultrasensitive gas detection down to individual molecule.
Sowing density rather than row spacing influences chia radiation use and yield
Authors: Anuch Tiranti Juan V. , Curti Ramiro N. , Acreche Martin Moises 
Published: October 2022

AbstractChia (Salvia hispanica L.) production worldwide has been encouraged due to its high essential fatty acid content that is effective for reducing cardiovascular affections. However, few studies have assessed the sowing density and row spacing to maximize chia grain yield (GY) and found controversial results. None of them reported effects on radiation interception and use efficiency that could help to clarify the controversial results. The objective of this study was to determine the effects of sowing density and row spacing on radiation interception and radiation use efficiency (RUE) of chia and their effects on chia growth and yield. Two field trials were conducted in Salta, Argentina, during 2017 and 2018, combining two factors: sowing density (5, 9, 13, 17, and 21 plants m−2) and row spacing (0.26 and 0.52 m). Photosynthetically active radiation (PAR) interception (PARi), RUE, biomass and GY components were measured. There was a clear effect of sowing density on the main growth and yield attributes, whereas there were no effects of row spacing. Sowing density had a greater impact on PARi than row spacing. Increasing sowing density increased PARi and RUE through earlier time of maximum PARi, accumulating more PAR producing more biomass and GY. Grain yield, which increased by 73 kg ha−1 per unit increase in plant density, was closely associated with biomass, grain number, and verticillaster number (VN), and negatively associated with 1,000‐grain weight (TGW). Summarizing sowing density rather than row spacing had a greater impact on growth and yield attributes of chia.
An expert‐in‐the‐loop method for domain‐specific document categorization based on small training data
Authors: Han Kanyao , Rezapour Rezvaneh , Nakamura Katia , Devkota Dikshya , Miller Daniel C. , Diesner Jana 
Published: October 2022

AbstractAutomated text categorization methods are of broad relevance for domain experts since they free researchers and practitioners from manual labeling, save their resources (e.g., time, labor), and enrich the data with information helpful to study substantive questions. Despite a variety of newly developed categorization methods that require substantial amounts of annotated data, little is known about how to build models when (a) labeling texts with categories requires substantial domain expertise and/or in‐depth reading, (b) only a few annotated documents are available for model training, and (c) no relevant computational resources, such as pretrained models, are available. In a collaboration with environmental scientists who study the socio‐ecological impact of funded biodiversity conservation projects, we develop a method that integrates deep domain expertise with computational models to automatically categorize project reports based on a small sample of 93 annotated documents. Our results suggest that domain expertise can improve automated categorization and that the magnitude of these improvements is influenced by the experts' understanding of categories and their confidence in their annotation, as well as data sparsity and additional category characteristics such as the portion of exclusive keywords that can identify a category.
Sustainability performance measurement in risk and uncertainty management: An analysis of base of the pyramid supply chain literature
Authors: Aman Sadaf , Seuring Stefan , Khalid Raja Usman 
Published: October 2022

AbstractRisk management in the base of the pyramid (BoP) environment is needed to ensure that firms performance objectives are met. Accordingly, integrating sustainability performance measurement in the supply chain risk management would offer interesting avenues for managing risks in BoP supply chain. Therefore, the paper conceptualizes an intersection between supply chain risk/uncertainty management and sustainable performance measurement. This intersection is then tested by a literature review of 164 BoP SC articles between the years 2000 and 2022. Descriptive, frequency, and correlation analysis identify various risks factors studied in the BoP literature so far, their management strategies and respective performance measures. The findings show a broad strategical aspect of managing SC risks and proffered the tactical or operational level performance measures which along with these practices can manage the related risks. Therefore, their incorporation into the risk management process should be considered. The correlation findings highlight the important role of performance process measures and the impact of these along with the management practices on firm's performance outcomes. The study contributes to supply chain risk and performance management literature by capturing the nexus between BoP and supply chain management.
Ellagic Acid Alleviates Mice Intestinal Ischemia‐Reperfusion Injury: A Study Based on Transcriptomics Combined with Functional Experiments
Authors: Fan Shuyuan , Xu Yue , Li Kun , Li Bin , Diao Yunpeng 
Published: October 2022

AbstractBackground: It has been reported that intestinal ischemia‐reperfusion injury (IIRI) is closely related to inflammatory response, apoptosis and oxidative stress. Ellagic acid (EA) has been proved to have antioxidant and anti‐inflammatory effects and can inhibit tumor angiogenesis. The purpose of this study was to investigate the protective effects of EA on IIRI in mice. Methods: A mouse model of IIRI was established by clamping the mesenteric artery. Effects and mechanisms of EA on IIRI were investigate by transcriptomics combined with functional experiments. Results: The symptoms of IIRI were reflected in significant increases in inflammatory factors such as TNF‐α and IL‐1β; significant increases in oxidative stress indicators such as MDA and GSH and decreases in SOD and promotion of the apoptotic protein Bax/Bcl‐2. These indicators were significantly alleviated by EA. And after EA treatment, transcriptomics results identified AKT1 differentially expressed mRNAs mainly enriched in PI3K/AKT signalling pathway. Conclusion: This study illustrates the protective effects against IIRI, the possible mechanisms were also studied. This study provides new scientific information for the application of EA in IIRI therapy.
Dynein localization and pronuclear movement in the C. elegans zygote
Authors: Ignacio David P. , Kravtsova Natalia , Henry John , Palomares Roberto Hernández , Dawes Adriana T. 
Published: October 2022

AbstractCentrosomes serve as a site for microtubule nucleation and these microtubules will grow and interact with the motor protein dynein at the cortex. The position of the centrosomes determines where the mitotic spindle will develop across all cell types. Centrosome positioning is achieved through dynein and microtubule‐mediated force generation. The mechanism and regulation of force generation during centrosome positioning are not fully understood. Centrosome and pronuclear movement in the first cell cycle of the Caenorhabditis elegans early embryo undergoes both centration and rotation prior to cell division. The proteins LET‐99 and GPB‐1 have been postulated to have a role in force generation associated with pronuclear centration and rotation dynamics. When the expression of these proteins is perturbed, pronuclear positioning exhibits a movement defect characterized by oscillatory (“wobble”) behavior of the pronuclear complex (PNC). To determine if this movement defect is due to an effect on cortical dynein distribution, we utilize RNAi‐mediated knockdown of LET‐99 and GPB‐1 to induce wobble and assay for any effects on GFP‐tagged dynein localization in the early C. elegans embryo. To compare and quantify the movement defect produced by the knockdown of LET‐99 and GPB‐1, we devised a quantification method that measures the strength of wobble (“wobble metric”) observed under these experimental conditions. Our quantification of pronuclear complex dynamics and dynein localization shows that loss of LET‐99 and GPB‐1 induces a similar movement defect which is independent of cortical dynein localization in the early C. elegans embryo.
FeOCl Nanodots and Doxorubicin Co‐loaded Polymer Nanoparticles for Glutathione/pH‐responsive Chemodynamic Therapy/Chemotherapy of Tumors
Authors: Yuwen Lihui , Zhang Yue , Xiao Huayu , Xiao Hang , Li Xiao , Yang Wenjing , Yang Zhaoxia , Dong Heng , Wang Lianhui 
Published: October 2022

AbstractChemodynamic therapy (CDT) based on the Fenton reaction has been considered as a promising solution for the treatment of tumors. However, the limited therapeutic efficacy and lack of responsive release of Fenton agents still hinder the further application of CDT. To this end, we designed a disulfide bond (−S−S−) cross‐linked polymer nanoparticles (poly(AA‐co‐DMA), PAD) to load FeOCl nanodots (FeOCl NDs) and doxorubicin (DOX) with the surface coating of bovine serum albumin (BSA) to prepare glutathione (GSH)/pH‐responsive PAD‐FeOCl/DOX@BSA nanoparticles (PFDB). In the tumor microenvironment (TME) with abundant GSH and acidic pH, the −S−S− bond in PFDB can be reduced and the linkage between the polymer chains is broken down, which facilitates the controlled release of FeOCl NDs and DOX. Both in vitro and in vivo experimental results showed that PFDB can serve as a GSH/pH‐responsive nanoagent for the effective killing of 4T1 tumor cells by combined CDT/chemotherapy. This study provides a promising TME‐responsive nanoagent with dual therapeutic modes for the effective treatment of tumors.
Novel single‐operator through‐the‐scope traction device for endoscopic submucosal dissection: Outcomes of a multicenter randomized pilot ex‐vivo study in trainees with limited endoscopic submucosal dissection experience (with video)
Authors: Yang Dennis , Aihara Hiroyuki , Hasan Muhammad K. , Simsek Cem , Khan Hafiz , Brar Tony S. , Gorrepati Venkata S. , Forde Justin J. , Kadkhodayan Kambiz , Arain Mustafa A. , Draganov Peter V. 
Published: October 2022

AbstractObjectivesEndoscopic submucosal dissection is a technically demanding procedure. The pilot study aimed to prospectively evaluate the efficacy and safety of a novel single‐operator through‐the‐scope dynamic traction device among trainees with limited endoscopic submucosal dissection (ESD) experience.MethodsRandomized, controlled, pilot study comparing traction‐assisted ESD (T‐ESD) versus conventional ESD (C‐ESD) in an ex‐vivo porcine stomach model. Trainees were randomized to group 1 (T‐ESD followed by C‐ESD) and group 2 (C‐ESD followed by T‐ESD). Lesions were created on the gravity‐dependent area of the stomachs. The primary outcome was submucosal dissection speed. Secondary outcomes included differences in en‐bloc resection, adverse events, and workload, assessed by the National Aeronautical and Space Administration Task Load Index (NASA‐TLX).ResultsFive trainees performed two T‐ESD and two C‐ESD each, for a total of 20 procedures. Submucosal dissection speed was significantly faster in the T‐ESD group compared to the C‐ESD group (43.32 ± 22.61 vs. 24.19 ± 15.86 mm2/min; p = 0.042). En‐bloc resection was achieved in 60% with T‐ESD and 70% with C‐ESD (p = 1.00). The muscle injury rate was higher in the C‐ESD group (50% vs. 10%; p = 0.21) with 1 perforation reported with C‐ESD and none with T‐ESD. NASA‐TLX physical demand was lower with T‐ESD compared to C‐ESD (4.5 ± 2.17 vs. 6.9 ± 2.50; p = 0.03).ConclusionT‐ESD resulted in faster submucosal dissection and less physical demand when compared to C‐ESD, as performed by trainees in an ex‐vivo gravity‐dependent model. Future studies are needed to assess its role in human ESD cases.
Reciprocal relationships between personality disorders and eating disorders in a prospective 17‐year follow‐up study
Authors: Eielsen Hanna Punsvik , Vrabel KariAnne , Hoffart Asle , Rø Øyvind , Rosenvinge Jan H. 
Published: October 2022

AbstractObjectiveThis study aimed to report the presence of categorical and dimensional personality disorders (PD) in adults with longstanding eating disorders (ED) over a period of 17 years and to investigate whether changes in PD predict changes in ED symptoms or vice versa.MethodsIn total, 62 of the 80 living patients (78% response rate) with anorexia nervosa (n = 23), bulimia nervosa (n = 25), or other specified feeding or ED (n = 14) at baseline were evaluated during hospital treatment and at 1‐year, 2‐year, 5‐year, and 17‐year follow‐up. PD were assessed using the Structured Clinical Interview for DSM‐IV Axis II disorders, and the eating disorder examination (EDE) interview was used to assess ED. Data were analyzed using multilevel modeling.ResultsFrom baseline to the 17‐year follow‐up, the number of patients with any PD decreased significantly from 74.2% to 24.2%, and the total number of PD diagnoses declined from 80 to 22. Mean EDE score was significantly reduced from 4.2 (SD: 1.1) to 2.0 (SD: 1.6). There was a positive association between ED and PD where the initial level of either disorder was followed by similar levels of the other disorder throughout the entire follow‐up period. High baseline levels of borderline PD predicted less decrease in ED symptoms. No significant within‐person effects were found.ConclusionsBoth ED and PD significantly declined over time. As the severity of either disorder seems to be associated with the other, thorough assessment and treatment that incorporates both the ED psychopathology and the personality disturbances are advisable.Public Significance StatementWhile personality disorders were highly prevalent in the sample of patients with longstanding eating disorders, both disorders were significantly reduced at the 17‐year follow‐up. The disorders are related in the sense that an initial high level of either disorder is associated with a high level of the other over time. A thorough assessment and attention to both illnesses are advisable in therapy.Clinical Trial IdentifierNCT03968705.
The interplay between prior selection, mild intermittent exposure, and acute severe exposure in phenotypic and transcriptional response to hypoxia
Authors: Ekwudo Millicent N. , Malek Morad C. , Anderson Cora E. , Yampolsky Lev Y. 
Published: October 2022

AbstractHypoxia has profound and diverse effects on aerobic organisms, disrupting oxidative phosphorylation and activating several protective pathways. Predictions have been made that exposure to mild intermittent hypoxia may be protective against more severe exposure and may extend lifespan. Here we report the lifespan effects of chronic, mild, intermittent hypoxia, and short‐term survival in acute severe hypoxia in four clones of Daphnia magna originating from either permanent or intermittent habitats. We test the hypothesis that acclimation to chronic mild intermittent hypoxia can extend lifespan through activation of antioxidant and stress‐tolerance pathways and increase survival in acute severe hypoxia through activation of oxygen transport and storage proteins and adjustment to carbohydrate metabolism. Unexpectedly, we show that chronic hypoxia extended the lifespan in the two clones originating from intermittent habitats but had the opposite effect in the two clones from permanent habitats, which also showed lower tolerance to acute hypoxia. Exposure to chronic hypoxia did not protect against acute hypoxia; to the contrary, Daphnia from the chronic hypoxia treatment had lower acute hypoxia tolerance than normoxic controls. Few transcripts changed their abundance in response to the chronic hypoxia treatment in any of the clones. After 12 h of acute hypoxia treatment, the transcriptional response was more pronounced, with numerous protein‐coding genes with functionality in oxygen transport, mitochondrial and respiratory metabolism, and gluconeogenesis, showing upregulation. While clones from intermittent habitats showed somewhat stronger differential expression in response to acute hypoxia than those from permanent habitats, contrary to predictions, there were no significant hypoxia‐by‐habitat of origin or chronic‐by‐acute treatment interactions. GO enrichment analysis revealed a possible hypoxia tolerance role by accelerating the molting cycle and regulating neuron survival through upregulation of cuticular proteins and neurotrophins, respectively.
Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells
Authors: Yao Jihang , Takenaga Keizo , Koshikawa Nobuko , Kida Yuki , Lin Jason , Watanabe Takayoshi , Maru Yoshiaki , Hippo Yoshitaka , Yamamoto Seigi , Zhu Yuyan , Nagase Hiroki 
Published: October 2022

AbstractCervical cancer remains a major threat to women's health, especially in countries with limited medical resources, and new drugs are needed to improve patient survival and minimize adverse effects. Here, we examine the effects of a triphenylphosphonium (TPP)‐conjugated pyrrole‐imidazole polyamide (CCC‐h1005) targeting the common homoplasmic mitochondrial DNA (mtDNA) cancer risk variant (ATP6 8860A>G) on the survival of cervical cancer cell lines, cisplatin‐resistant HeLa cells and patient‐derived cervical clear cell carcinoma cells as models of cervical cancer treatment. We found that CCC‐h1005 induced death in these cells and suppressed the growth of xenografted HeLa tumors with no severe adverse effects. These results suggest that PIP‐TPP designed to target mtDNA cancer risk variants can be used to treat many cervical cancers harboring high copies of the target variant, providing a foundation for clinical trials of this class of molecules for treating cervical cancer and other types of cancers.
Exchange rate pass‐through to consumer prices in India – nonlinear evidence from a smooth transition model
Authors: Bhat Javed Ahmad , Nain Md Zulquar , Bhat Sajad Ahmad 
Published: October 2022

AbstractUsing a backward‐looking Philips curve framework and a Logistic Smooth Transition Regression (STR) model, this article examined the exchange rate pass‐through (ERPT) to final consumer prices in the case of India. Specifically, the nonlinearity of ERPT has been investigated with respect to the level of economic activity and the rate of inflation by considering two alternative measures of exchange rate. For the first transition variable, results are markedly different between high and low‐activity regimes and signify the favourable impact of economic activity on the extent of pass‐through. In the short run, 1% exchange rate appreciation would decrease the price level by 0.244% when the economy is in a low‐activity regime; however, the same appreciation increases the price level by 0.485% when there is a boom in the economy. In the long run, ERPT in the low‐activity regime is −0.358, and in the high‐activity regime, it is 0.039. In both regimes, pass‐through coefficients differ from zero and one, implying that neither local currency pricing nor producer currency pricing characterizes the ERPT mechanism. The impact of other important determinants of inflation is also well according to theoretical expectations. Finally, for the rate of inflation, we did not report any evidence favouring the Taylor hypothesis in the case of India.