bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Approach for Designing an Underbalanced Cementing Plug Using a Managed Pressure Cementing and Pump-Pull Method with Narrow Pore-Frac Pressure Window in HPHT Exploration Well: An Offshore East Kalimantan, Indonesia Case Study
Authors: Setiohadi _ , Hadistira Praja , Yudhatama Muhammad Alfianoor , Sitompul Daniel , Hutabarat Dhika Escodianto , WIharja Andre , Panjaitan Reinhard Aberson , Agriawan Crisa , Kusumawatie Reny , Wedhaswari Victoria Rasmi , Darmanto Bagus Setyo , Osman Ahmed , Azwar Cinto , Winarti Wiwin , Simanjuntak Andre 
Published: October 2022

Abstract
The operator was drilling their first high-pressure high-temperature (HPHT) exploration well with narrow pressure window in a swamp area of East Kalimantan. The gas field was discovered in 1977 and production started in 1990. Since then, more than 1500 wells have been drilled in this area yielding a total gas production of 9.7 Tcf. Currently T field enters established mature field status which has quite marginal reserves. Therefore, further exploration is seen as one of the solutions to locate additional reserves to enhance overall gas production. The well was drilled directionally with no offset well nearby. While drilling the 6-in open hole section, an unexpected high-pressure zone was penetrated. The zone condition was made worse by lost circulation and a high gas reading.
Two cement plugs were placed using a managed pressure cementing with pump and pull method. The first plug was set by applying surface back pressure (SBP) to maintain equivalent bottom hole pressure (BHP) between lowermost pore pressure (PP) and fracture gradient (FG) at the previous shoe. After pumping 1 m3 of cement into the annulus, pump and pull operations commenced. While performing post job circulation on the first plug, it was observed that the returned fluid density at surface was less than original mud weight, indicating the possibility of contaminant invasion from formation. After waiting for the cement to reach 500 psi compressive strength, pressure buildup was observed when annulus was shut-in, indicating an inadequate pressure seal across the cement plug
Applying lessons learned from setting the first plug, new design considerations were implemented such as increasing cement volume in the annulus to 4 m3 prior to the pump and pull operation to minimize cement overlapping risk and applying SBP at BHP near FG. A contingency plan was in place to determine the appropriate SBP value to be applied whenever the pumping rate was changed. A second plug job was performed safely and flawlessly by achieving the top of cement as desired. A successful inflow test was performed with indication of no contaminant invasion nor pressure bypass around the cement plug. The rig was able to continue its next operation to sidetrack the well.
This paper presents the design considerations, methodology applied, and lessons learned two managed pressure cement plugs using pump and pull method in a well bore with a narrow pore-frac window where the new techniques were implemented to enhance success of the plug job despite the complexity and risk inherent with an underbalanced operation.
Effects of dietary habits and catheterization type on breast cancer-related lymphedema: a retrospective cohort study
Authors: Wang Ling , Zhen Meixin , Li Hui , Yan Huang , Jiang Botao , Wiley James A. , Chen Xuemei , Yv Jun , Ding Boni , Yang Dongliang 
Published: October 2022

Abstract
Background Understanding the factors that contribute to variability in breast cancer-related lymphedema (BCRL) is an important first step in developing targeted interventions to improve quality of life in breast cancer patients. Although previous research studies have has identified many risk factors for BCRL, dietary habits and catheterization type have rarely been studied until the present.This study aims to explore the effects of dietary habits and catheterization type on BCRL.
Methods This study included 1,476 breast cancer patients after surgery between January 1, 2010 and September 1, 2020. Lymphedema was assessed with a validated self-reported questionnaire. All research data was obtained by medical records and follow-up database. Survival analysis was conducted to explore the effects of dietary habits and catheterization type on BCRL.
Results The result showed an increased risk for BCRL among breast cancer patients who followed a high-fat diet pre-hospitalization (hazard ratio [HR] =2.473; P<0.001), indwelling totally implantable venous access ports (TIVAPs) compared with indwelling needle (HR=0.558; P=0.017) and indwelling TIVAPs, compared with anindwelling peripherally inserted central catheter (PICC) (HR=0.691; P=0.086).
Conclusion High-fat diet pre-hospitalization was an independent risk factor for lymphedema. The TIVAPs did not exert a protective effect on lymphedema compared with the PICC and indwelling needle. This study finding offers new insights to develop targeted interventions to decrease the incidence of lymphedema.
Polypharmacy in patients with chronic liver disease: a systematic review of definitions
Authors: Danjuma Mohammed I , ansari soubiya , Abu-Affifeh Leen Maen , Altikrity Nawras , Al-Sr Aisha , Jumbo Unwam , Naseralallah Lina 
Published: October 2022

Abstract
Background

Despite its central role in drug metabolism, there is still residual uncertainty regarding the rising burden as well as exact definition of polypharmacy in patients with chronic liver disease.

Methods

We carried out a systematic search of EMBASE, PUBMED, Cochrane Database of Systematic Reviews, Science Citation Index, and Database of Abstracts of Reviews of Effects (DARE) between 1st January 2000 and 30th January 2022 for studies exploring polypharmacy in patients with chronic liver disease. We excluded studies that had no explicit numerical or descriptive definition of polypharmacy.

Results

We retrieve (N = 171) reports from systematic literature search with six studies (N = 918 548 patients) meeting criteria for inclusion in the review. A total of (N = 8) iterations of polypharmacy definitions were retrieved with numerical definitions (≥ 5 medications) constituting up about 62.5% of this. The latter is the most reported definition of polypharmacy. Two studies described polypharmacy based on the duration of exposure. None of the reviewed studies examined the constituent of polypharmacy (i.e., whether liver-related or non-liver related medications).

Conclusion

In a systematic review of current reports on medication counts in patients with chronic liver disease, we found an intake of 5 or more medications as consistent with the definition of polypharmacy in this patient cohorts. It remains uncertain if adoption of “non-liver related polypharmacy” as a definition will best characterize this therapeutic morbidity in these cohorts of patients.
Prospero Number: CRD42022306572
Study on the variation of MeHg content in different types of soils in non-ferrous metallurgical areas
Authors: Xinyu Li , Dongmei Zheng , Yuqi Wang , Xiaoxiao Xu 
Published: October 2022

Abstract
To study the methylation of mercury in soils of various utilization categories in typical non-ferrous metallurgical areas, soils of various utilization categories were selected for the experiment, and the changes of soil mercury, methylmercury, and SRB content were analyzed, whether the changes of SRB and the changes of soil physical and chemical properties affected the formation of methylmercury, and the results showed that: with the incubation time increased, the mercury content showed a decreasing-increasing-reducing trend. Except for the riverbank substrate, the MeHg content of the other five different land-use types exhibited a trend of rising and then falling, and the MeHg content of soils under flooded conditions was higher than that of non-flooded soils. SRB was present in all types of soils and promoted soil Hg methylation in the late incubation period. Among soil physical and chemical properties, pH and soluble sulfide were significantly correlated with MeHg content in some soils, indicating that MeHg formation was related to SRB, pH, and soluble sulfide, which is important for the study of different types of soils in non-ferrous metallurgical areas.
Association of discordance between Anti-Müllerian Hormone (AMH) and antral follicle count (AFC) with obesity in in vitro fertilization patients: a retrospective cohort study
Authors: Chen Yannan , Gu Xiaoling , Guan Xi , Yu Minyan , Zhong Shuping , Yang Panpan , Wang Xia , Wang Di 
Published: October 2022

Abstract
Background: Both anti-Mullerian hormone (AMH) and antral follicle count (AFC) predict ovarian reserve independently and have been shown to correlate well. However, it is quite common to encounter discordance between the two clinical indices. This objective of this study is to speculate which condition is favorable to patients and to decide what best to be done in cases of such discordance.
Methods: This retrospective cohort study analyzed the medical records of 714 women undergoing the first IVF cycle at the Center for Reproductive Medicine, the Affiliated Hospital of Nantong University, Nantong, Jiangsu between January 2017 and December 2020. All patients had their essential characteristics, baseline FSH, Estradiol, PRL, LH, Testosterone, CA125, AMH, and AFC recorded. Patients were classified into three groups according to whether their AMH and AFC values were in the lower quartile, upper quartile, or in between, namely Group A (Concordance, concordant in AMH and AFC), Group B (HTP, AMH concentration higher than predicted according to AFC) and Group C (LTP, AMH concentration lower than predicted according to AFC). SPSS 25.0 software package (SPSS, Inc., Chicago, IL, USA) was used for statistical analysis.
Results: The entire study population has a good concordance between AMH and AFC. 240 women (33.61%) had discordant AMH and AFC values, and the proportion in Group B(HTP) and Group C(LTP) seemed similar (16.67% VS 16.94%). The three cohorts had similar age, infertile duration, FSH, Estradiol, PRL, LH, Testosterone, and CA125 levels. BMI progressively increased from Group B to Group A and to Group C. The ratio of patients, who had completely mature oocytes (COM), rapidly decreased from Group C to Group A and to Group B. Although no significant difference in CMO rate was observed among Group A, B, and C when stratified according to BMI, CMO rate was the highest (72.31%) when BMI< 18.5 kg/m2 in all BMI categories.
Conclusions: Our analysis demonstrated a high frequency of clinical discordance between AMH and AFC in women undergoing IVF therapeutic regime. Patients’ BMI and completely mature oocytes ratio are significantly different among distinct grouping based on their AMH and AFC partition.
Effects of moisture content and landfill age on the shear strength properties of municipal solid waste in Xi'an, China
Authors: Huang Menghe , Zhang Zhenying , Lan Jiwu , Zhang Jiahe , Xu Hui 
Published: October 2022

Abstract
As waste landfills continue to expand, accidents can occur if these landfills are not properly stabilized. In this study, samples of municipal solid waste (MSW) from a waste landfill in Xi'an, China were collected through on-site drilling. Considering the effects of eight landfill ages (1, 2, 3, 11, 12, 13, 21, 22, and 23 y) and six moisture contents (natural, 20, 40, 60, 80, and 100%), 324 groups of MSW were tested in the laboratory with a direct shear test apparatus. The results indicate the following: (1) with an increase in horizontal shear displacement, the shear stress of MSW gradually increases without a peak stress phenomenon, which is a displacement hardening curve; (2) with an increase in landfill age, the shear strength of MSW increases; (3) with an increase in moisture content, the shear strength of low-age MSW first increases and then decreases, but the relationship between shear strength and moisture content of medium- and high-age MSW is not significant; (4) with an increase in landfill age, the cohesion (c) decreases, and the internal friction angle (φ) increases; (5) with an increase in moisture content, the c and φ of low-age MSW first increases and then decreases. Based on these results, a shear strength, landfill age, and moisture content correlation model is established, and the model has a high degree of fit with the overall experimental data. The results of this study can provide a reference for the stability calculations of MSW landfills.
The effect of motivational interviewing and/or cognitive behaviour therapy on gestational weight gain – a systematic review and meta-analysis
Authors: Nightingale Helen , Mnatzaganian George , Hooker Leesa , Barrett Stephen , Kingsley Michael 
Published: October 2022

Abstract
Background
Women with insufficient or excessive weight gain in pregnancy are at risk of adverse perinatal outcomes. Motivational interviewing and/or cognitive behaviour therapy have demonstrated efficacy in initiating and sustaining behaviour change, including weight control. The objective of this review was to investigate the effect of antenatal interventions that include components of motivational interviewing and/or cognitive behaviour therapy on gestational weight gain.
Methods
Five electronic databases were systematically searched to March 2022. Randomised controlled trials evaluating interventions with identified components of motivational interviewing and/or cognitive behaviour therapies were included. Pooled proportions of appropriate and inappropriate gestational weight gain, and standardised mean difference for total gestational weight gain, were calculated. Grades of Recommendation, Assessment, Development and Evaluation approach was used to evaluate the quality of evidence.
Results
Twenty-one studies (8030 participants) were included. Overall, the intervention limited total gestational weight gain (-0.18 kg, 95% confidence interval: -0.27 to -0.09 kg) and improved the proportion of women achieving recommended gestational weight gain (29% versus 23%, p < 0.001), but the evidence is very uncertain. The magnitude of effect was greater in women with overweight or obesity when compared to women with BMI < 25 kg/m2.
Conclusion
Motivational interviewing and/or cognitive behaviour therapy techniques might be effective for promoting healthy gestational weight gain. Nevertheless, a high proportion of women do not achieve recommended gestational weight gain. Future interventions should consider factors, including user perspectives, in the design and delivery of psychosocial interventions that aim to support healthy gestational weight gain.
Study registration:
The protocol for this review was registered with the PROSPERO International register of systematic reviews (registration number CRD 42020156401).
Effectiveness of Deprescribing Interventions in Older Adults: An Overview of Systematic Reviews
Authors: Chua Shiyun , Todd Adam , Reeve Emily , Smith Susan M , Elsisi Zizi , Hughes Stephen , Husband Andrew , Huang Yuhan , Harris Jeffrey R , Devine Beth , Gray Shelly 
Published: October 2022

Abstract
Background: Rigorous evidence to guide deprescribing is limited, and priorities to inform deprescribing research and practice remain unclear. The objective of this overview of systematic reviews (i.e. reviews) was to synthesize the available review evidence regarding the effectiveness of interventions to deprescribe medications in older adults.
Methods
11 databases were searched from January 2005 to October 2020. We included randomized or non-randomized controlled designs. Two independent reviewers screened and extracted data. We synthesized results in two steps: Step 1 identified results as reported by the original review (including meta-analyses) and Step 2 involved a narrative synthesis of reviews by outcome. Pre-specified subgroups included patient characteristics (e.g., dementia, frailty, advanced age), intervention type and setting. Outcomes included medication-related outcomes (e.g., medication reduction, potentially inappropriate medications) or other outcomes(e.g., mortality, adverse effects, falls, cognition, hospitalizations, quality of life, costs, surrogate biomarkers). Assessment of Multiple Systematic Reviews 2 was used to assess quality of reviews.
RESULTS: 2,335 unique citations were retrieved, of which 93 full-text articles were assessed for eligibility. 33 reviews (encompassing 13 meta-analyses) were included. 19 of the 33 reviews had a general deprescribing focus, 13 focused on specific medication classes or therapeutic category and one review included both. Ten of 13 reviews meta-analyzed medication-related outcomes (29 outcomes: 21 favored the intervention, seven reported no difference and one favored the comparison). The narrative synthesis indicated that most interventions resulted in some evidence of medication reduction. Few meta-analyses reported on other outcomes, and our narrative synthesis found primarily mixed effects or no evidence of an effect on these outcomes. Limited information was available for patient characteristic subgroups. All reviews scored low or critically low on quality assessment.
CONCLUSIONS: Deprescribing interventions likely resulted in medication reduction. Information about other outcomes was not routinely examined, and where included, studies were likely underpowered. The evidence, though of low quality, suggests deprescribing was not associated with increased adverse events, and had little evidence of effect on mortality, quality of life and health-care use. Future research should focus on designing studies powered to examine harms, patient-centered outcomes and the effects on vulnerable subgroups.
Systematic Review Registration
PROSPERO CRD42020178860
This study was supported by NIA (1R24AG064025).
Hydrochemistry; Compliance And Comparative Case Study of Public Water Works In Enugu And Ebonyi States, Southeast of Nigeria
Authors: J Okenwa C. , P Ikeyi A. , N Owoh E. , E Chinyere E. , C Nnonah C. , onunze Emmanuel. C. 
Published: October 2022

Abstract
The compliance and comparative case study of public water works in Enugu and Ebonyi State of Nigeria was carried out in this study. The water samples were collected at Ajali water treatment plant Enugu State (Sample A), 9 Works road GRA, Enugu State (Sample B), Ezilo water Scheme Ebonyi State (Sample C) and Ameke in Ezilo Ebonyi State (Sample D). Ten physicochemical parameters and water like- metals such as SO42−, Cl−, NO3, Mg2+, Ca2+, Na+, Pb, Ni, Cr, and Al were determined in rainy season in for one year. The results shows that chloride (Cl−), (A = 97 mg/l, B = 121 mg/l, C = 97 mg/l, D = 119 mg/l); nitrate, (A = 3.11 mg/l, B = 1.29 mg/l, C = 1.10 mg/l, D = 0.70 mg/l); total phosphate, (A = 1.97 mg/l, B = 0.26 mg/l, C = 0.32 mg/l, D = 0.42 mg/l); Biological oxygen demand (BOD), (A = 0.25 mg/l, 6.00 mg/k, C = 1.10 mg/l, D = 7.40 mg/l); Chemical oxygen demand (COD), (A = 50.67 mg/l 10.67 mg/l, C = 30.39 mg/l, D = 26.67 mg/l); Electrical conductivity (EC), (A = 100 µs/cm, B = 30 µs/cm, C = 200 µs/cm, D = 250 µs/cm); and pH, (A = 7.60, B = 6.62, C = 5.50, D = 5.90) mostly conform to the WHO set standard for drinking water. While TS, TDS, and TSS were (A = 205, B = 535, C = 151, D = 183 mg/l), (A =,60 B = 555, C = 121, D = 128 mg/l) and (A = 145, B = 280, C = 30, D = 55 mg/l) respectively. Further more, the results of the heavy metal analysed showed that; Lead (Pb) was not detected in all water samples; Nickel (Ni) was observed to be 0.07 mg/l in the water sample collected from Sample A; Sample B contained 0.03 mg/l; Sample C not detected while in Sample D, it was 0.04 mg/l;. Chromium (Cr) was observed to be 0.01 mg/l in Sample A, it was not detected in both water samples B and C but was 0.02 mg/l in Sample D; which means that all the water samples studied conform to the WHO set standard for chromium in drinking water. Aluminium (Al) was observed to be 0.05 mg/l, 0.01 mg/l, Not detected and 0.03 mg/l in water sample A, Sample B, Sample C and Sample D. There is a variation in the Mg2+ in Ebonyi water. Hpwever, It was observed that the physical parameters of the water samples analysed were within the World Health Organisation (WHO) set standard for drinking water.
Development of Real-time PCR Method for Detection and Quantification of the Coral Pathogenic Strain XSBZ14
Authors: Zhang Na , Yang Siyue , Zhang Xiang , Long Hao , Cai Xiaoni , Fu Yanan , Xie Zhenyu 
Published: October 2022

Abstract
Purpose
Coral degradation is a worldwide ecological problem. Bacterial diseases are a great danger to coral health. However the bacterial communities in coral reef ecosystems are complex and variable. Therefore, real-time and accurate detection of coral pathogenic bacteria is necessary. This study aims to develop a detection method for pathogenic bacteria Vibrio alginolytcus XSBZ14, which could cause Porites andrewsi white syndrome (PAWS), is an enormous threat to coral reef ecosystem in the South China Sea. That could provide help for the protection of coral reefs in the South China Sea.
Methods
At first, a low sequence identity single-copy sequence S2 was selected from the genome by in-house perl script. Using the designed specific primers, four different types of standard curves were subsequently plotted for the accurate quantification of the strain XSBZ14 in four different samples (DNA, bacterial suspension, coral tissue, seawater). Then, using the strain to infect the Galaxea fascicularis and test the strain in the coral culture water during the week.
Results
The rapid detection method of pathogenic bacteria by RT-PCR was established. The limit of detection (LOD) of the RT-PCR was 0.88 pg/reaction (0.44 pg/µL) in DNA, 2 CFU/reaction (1000 CFU/mL) in bacterial suspension, 2 CFU/reaction in coral tissue, 20 CFU/reaction in seawater for the strain XSBZ14, respectively. In addition, according to the detection results of the RT-PCR, the strain XSBZ14 could survive in Galaxea fascicularis for a week, and the strain could also be detected from its reared seawater.
Conclusion
These results indicated that other coral species and their habitats might act as an important reservoir for the strain XSBZ14 and mediated its horizontal transmission in coral reefs. In a word, the RT-PCR detection method of a coral pathogenic strain XSBZ14 was firstly established. The method is a robust tool for the rapid detection and quantification of the coral pathogen, XSBZ14, and is very useful for PAWS epidemiological survey and specific pathogen-free coral transplantation in the South China Sea.
Prognostic effect of albumin-to-alkaline phosphatase ratio on patients with hepatocellular carcinoma: a systematic review and meta-analysis.
Authors: Zhang Xinyuan , Xin Yujing , Yang Yi , Chen Yi , Zhou Xiang 
Published: October 2022

Abstract
Background
The prognostic value of albumin-to-alkaline phosphatase ratio (AAPR) in patients with hepatocellular carcinoma (HCC) remains controversial. This meta-analysis aims to evaluate the prognostic role of AAPR in patients with HCC.
Methods
The databases of Web of Science, Embase, Cochrane Library and PubMed were comprehensively searched from inception to April 25, 2022. Pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated with Stata 16.0 software for the assessment of the relationship between AAPR and overall survival (OS) as well as disease-free survival (DFS) in patients with HCC.
Results
A total of 2634 patients from 12 cohorts were included in this meta-analysis. The pooled results showed that lower AAPR was significantly associated with poorer OS (HR: 2.02, 95% CI: 1.78–2.30). Similarly, pooled results demonstrated that lower AAPR was also significantly associated with poorer DFS (HR: 1.61, 95% CI: 1.36–1.92). Heterogeneity for DFS and publication bias for OS existed, however, the subgroup analysis, meta-regression analysis as well as adjustment using trim-and-fill analysis confirmed a stable interaction between AAPR and OS as well as DFS.
Conclusions
This meta-analysis proves that lower AAPR was significantly associated with poorer OS and DFS in patients with HCC, and AAPR could be a promising indicator for prognosis of HCC.