bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient control and multi‐criteria energy scheduling of renewable‐based utility grid via pareto‐metaheuristic optimizers
Authors: Ramadan Haitham S. , Iqbal Mehroze , Becherif Mohamed , Haes Alhelou Hassan 
Published: March 2022

AbstractBeing a renewable influenced utility grid, the wind integrated hydrothermal system (WHTS) is considered as a future‐proof and contemporary energy system to reduce the dependency on depleting fossil fuels. However, due to intermittent nature of wind energy and complex operational constraints, offering the day‐ahead operation schedule of WHTS with joint awareness of fuel economy and emissions is classified as a complicated multi‐objective optimization problem. The major challenge is to maximize the utilization of clean hydro power to accommodate uncertain wind energy together with reduced dependency on fossils based thermal power. In this context, the paper devises an efficient control and multi‐criteria energy scheduling method, essentially comprised of adaptive repair and volume restriction to maximize the utilization of available hydro power. The pareto‐metaheuristic optimizer based on non‐dominated sorting is exploited for the day‐ahead scheduling of WHTS based utility grid. The most appropriate solution from pareto‐optimal archive is selected using fuzzy‐ranking index. The expected reductions in fuel cost and emissions are reflected using a significant probability scheme. The effectiveness of the proposed approach based on pareto‐metaheuristic is appraised by various case studies. The simulation results provide a suitable day‐ahead generation schedule of WHTS based grid, considering both economics and environmental aspects.
Cannabinoids as New Drug Candidates for the Treatment of Glaucoma
Authors: Jordan Erin , Nguyen Gia-Nam , Piechot Alexander , Kayser Oliver 
Published: March 2022

AbstractGlaucoma is a blinding eye disease that affects about 70 million patients globally today. The cannabinoid receptors and the endocannabinoid system have found attention for new drug
concepts. This review will analyze the potential of cannabinoids, primarily tetrahydrocannabinol, THCVS, and cannabinol, as drug candidates and the role of CB1/CB2 receptors with regard to
the pathophysiology of glaucoma. The mode of action of cannabinoids as innovative drug candidates and recent formulations for topical delivery will be discussed. Cannabinoid receptors with
associated TRPV channels will be evaluated for their potential as drug targets. Especially the role of the endocannabinoid system (fatty acid amide hydrolase, monoacylglycerol lipase)
impacting the prostaglandin network (cyclooxygenase, PGE, PGF) and neuroprotection by inhibition of nitric oxide radical formation is in the focus of this review. Delivery systems, including
recent clinical trials, will be analyzed to evaluate the potential for innovative future ophthalmological drugs.
Effects of Proprioception Training with Kinesio Taping of the Knee
Joints on the Proprioception, Balance, and Gait in Stroke Patients: A
Single-Blind Randomized Trials
Authors: Kim Kyung Hun , Kim Dong Hoon , Kim Jin Hong 
Published: March 2022

AbstractThe purpose of this study was to determine the effects of proprioception training
with kinesio taping (PTKT) of the knee joints on the proprioception, balance and
gait in Stroke Patients. The subjects were randomly divided into the PTKT group
and control group, with subjects assigned to each group. In the PTKT group,
proprioception training with kinesio taping was performed for 4 weeks. The
control group was conducted in the same method except placebo kinesio taping.
Proprioception error measure using the electrogoniometer.. The balance ability
was measure using the pressure plate. Gait ability was evaluated using G-Walk.
The proprioception error, balance ability, and gait were significantly more
improved in the PTKT group than in the control group (p<0.05). These
findings suggest that proprioception training with kinesio taping of the knee
joints for proprioception, balance and gait in stroke patients.
Synthesis of 1,5-Disubstituted Tetrazoles from Nitrones by Using Bis(p-nitrophenyl) Phosphorazidate in the Presence of 4-(Dimethylamino)pyridine
Authors: Matsugi Masato , Ishihara Kotaro , Shioiri Takayuki 
Published: March 2022

AbstractA novel method has been developed for the synthesis of 1,5-disubstituted tetrazoles from nitrones by using bis(p-nitrophenyl) phosphorazidate in the presence of 4-(dimethylamino)pyridine. By this approach, various nitrones were converted into the corresponding tetrazoles. This method permits the preparation of 1,5-disubstituted tetrazoles without the need for toxic or explosive reagents.
Enantioselective Cobalt-Catalyzed C–H Functionalization
Authors: Ye Mengchun , Xu Weiwei 
Published: March 2022

AbstractCo-catalyzed C–H functionalization has received great attention due to the high earth abundance, low biotoxicity, and unique reactivity of cobalt; enantioselective control of these reactions has been a formidable challenge. Various efficient strategies have recently been developed for enantioselective Co-catalyzed C–H functionalization, but there is no topical review of this field. Herein, we give a detailed summary of this rapidly growing field, highlighting critical progress, current challenges, and future trends.1	Introduction2	Enantioselective C–H Functionalization via Low-Valent Co Catalysis2.1	Chiral Diphosphines for Enantioselective Control2.2	Chiral Monophosphines or N-Heterocyclic Carbenes for Enantioselective Control3	Enantioselective C–H Functionalization via High-Valent Co Catalysis3.1	Chiral Acids for Enantioselective Control3.2	Chiral Cp Ligands for Enantioselective Control4	Conclusions and Outlook
Outcomes of Moderately Preterm Infants of Insulin-Dependent Diabetic Mothers
Authors: Gray Keyaria D. , Saha Shampa , Battarbee Ashley N. , Cotten Charles Michael , Boghossian Nansi S. , Walsh Michele C. , Greenberg Rachel G. ,   for the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network
Published: March 2022

Objective Little is known about the hospital outcomes of moderately preterm (MPT; 29 0/7–33 6/7 weeks gestational age) infants born to insulin-dependent diabetic mothers (IDDMs). We evaluated characteristics and outcomes of MPT infants born to IDDMs compared with those without IDDM (non-IDDM).
Study Design Cohort study of infants from 18 centers included in the MPT infant database from 2012 to 2013. We compared characteristics and outcomes of infants born to IDDMs and non-IDDMs.
Results Of 7,036 infants, 527 (7.5%) were born to IDDMs. Infants of IDDMs were larger at birth, more often received continuous positive pressure ventilation in the delivery room, and had higher risk of patent ductus arteriosus (adjusted relative risk or aRR: 1.49, 95% confidence interval [CI]: 1.20–1.85) and continued hospitalization at 40 weeks postmenstrual age (aRR: 1.55, 95% CI: 1.18–2.05).
Conclusion MPT infants of IDDM received more respiratory support and prolonged hospitalizations, providing further evidence of the important neonatal health consequences of maternal diabetes.
Key Points
Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3-a]azines as Potential HSF1 Inductors
Authors: Utepova Irina A. , Serebrennikova Polina O. , Chupakhin Oleg N. , Guzhova Irina V. , Mikhaylova Elena R. , Antonchick Andrey P. 
Published: March 2022

AbstractDerivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation.
Spirocyclic Products via Carbene Intermediates from Thermolysis of 1,2-Dialkynylpyrrole and 1,2-Diethynylimidazole
Authors: Kerwin Sean M. , Jewett Ashley L. , Bondoc Joshua A. , Gilbreath Bradford L. , Reinus Brandon J. 
Published: March 2022

AbstractThe thermal rearrangements of 1,2-dialkynylimidazoles have been shown to lead to trapping products of cyclopenta[b]pyrazine carbene intermediates. Here we show that a similar rearrangement also occurs in the case of 1,2-diethynyl-1H-pyrrole, and that trapping the intermediate cyclopenta[b]pyridine carbene with solvent THF affords an ylide that undergoes a Stevens rearrangement to a spirocyclic product. An analogous rearrangement and trapping is observed for thermolysis of 1,2-dialkynylimidazoles in THF or 1,4-dioxane.
Concise Synthesis of (1R,2S,3R,6R)-6-Ethoxy-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, a Key Intermediate for the Synthesis of Uvacalols I and J
Authors: Rao Batchu Venkateswara , Surender Banothu , Vinaykumar Allam , Bharathkumar Hanumantharayappa 
Published: March 2022

AbstractUvacalols are novel carbasugars isolated from the genera Uvaria. In this study, we report concise syntheses of (1R,2S,3R,6R)-6-ethoxy-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, a key intermediate for the synthesis of uvacalols I and J, and of its epimer (1R,2S,3S,6R)-6-ethoxy-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, starting from cheap and readily available methyl d-glucopyranoside.
Efficacy of Individualized Homeopathic Medicines in Treatment of Acne Vulgaris: A Double-Blind, Randomized, Placebo-Controlled Trial
Authors: Rai Shruti , Gupta Gobind Narayan , Singh Subhas , Michael James , Misra Pankhuri , Gupta Bharti , Singh Suman , Prakash Akshaya , Tomar Maneela , Sadhukhan Satarupa , Koley Munmun , Saha Subhranil 
Published: March 2022

Abstract
Background Acne is estimated to affect 9.4% of the global population, making it the 8th most prevalent disease worldwide. Acne vulgaris (AV) is among the diseases that directly affect quality of life. This trial evaluated the efficacy of individualized homeopathic medicines (IHM) against placebo in AV.
Methods In this double-blind, randomized, placebo-controlled trial conducted at the National Institute of Homoeopathy, India, 126 patients suffering from AV were randomized in a 1:1 ratio to receive either IHM (verum) in centesimal potencies or identical-looking placebo (control). The primary outcome measure was the Global Acne Grading System score; secondary outcomes were the Cardiff Acne Disability Index and Dermatology Life Quality Index questionnaires — all measured at baseline and 3 months after the intervention. Group differences and effect sizes (Cohen's d) were calculated on the intention-to-treat sample.
Results Overall, improvements were greater in the IHM group than placebo, with small to medium effect sizes after 3 months of intervention; however, the inter-group differences were statistically non-significant. Sulphur (17.5%), Natrum muriaticum (15.1%), Calcarea phosphorica (14.3%), Pulsatilla nigricans (10.3%), and Antimonium crudum (7.1%) were the most frequently prescribed medicines; Pulsatilla nigricans, Tuberculinum bovinum and Natrum muriaticum were the most effective of those used. No harms, unintended effects, homeopathic aggravations or any serious adverse events were reported from either group.
Conclusion There was non-significant direction of effect favoring homeopathy against placebo in the treatment of AV.
Trial Registration CTRI/2018/11/016248; UTN: U1111–1221–8164.
Unexpected Intermediate Nerve Conduction Velocity Findings in Charcot-Marie-Tooth Syndromes Classified as Demyelinated or Axonal in a Pediatric Population
Authors: Baudou Eloïse , Cances Claude , Magdelaine Corinne , Latour Philippe , Louvier Ulrike Walther , Juntas-morales Raul , Cintas Pascal , Rivier François 
Published: March 2022

Abstract
Introduction Among the hereditary motor and sensory neuropathies (HMSN), demyelinating forms are the best characterized, with a clear predominance of CMT1A. The axonal and intermediate forms are less described. The aim of this study is to report the genetic diagnosis of Charcot-Marie-Tooth (CMT) according to the nerve conduction velocity (NCV) findings in a pediatric population.
Methods We retrospectively described a population of HMSN children with a confirmed genetic diagnosis of demyelinated, intermediate, or axonal forms. We compared the results of the genetic analyses with those of motor NCV in median nerve according to whether they were below 25 m/s (demyelinating group); between 25 and 45 m/s (intermediate group), or above 45 m/s (axonal group).
Results Among the 143 children with an HMSN, 107 had a genetic diagnosis of which 61 had an electromyogram. On NCV findings: seven (11%) pertain to the axonal group, 20 (32%) to the intermediate group, and 34 (55%) to the demyelinating group. When NCV was above 45 m/s, CMT2A was the predominant genetic diagnosis (70%) when NCV were below 25 m/s, CMT1A was the predominant genetic diagnosis (71%). Intermediate NCV findings group was the more heterogeneous with seven genetic CMT subgroups (60% CMT1A, CMT1B, CMT1X, CMT2A, CMT2N, CMT4G).
Conclusion Taking NCV values between 25 and 45 m/s to define an intermediate group of CMT in children leads to the inclusion of non-typically “intermediate”, especially CMT1A. We emphasize the broad spectrum of NCV in CMT1A that justified the systematic search of PMP22 duplication/deletion screening before next generation sequencing panel.
Thai Menschenbild: A Study of Chinese, Thai, and International Students in a Private Thai University as measured by the National Survey of Student Engagement (NSSE)
Authors: Waters Tony , Day Michael James 
Published: March 2022

AbstractThai Higher Education (Thai HE) is changing, due to international reform. This paper presents data collected in a longitudinal study carried out in Thailand during 2017–2018 using the US version of the National Survey of Student Engagement (NSSE) and qualitative interviews. We offer a case study about the cultures and engagement of three groups of students found at an international private university in Thailand. The groups studied were international students, Chinese students in a mixed Thai/English curriculum and Thai students studying in Thai, all situated in a Thai HE institutional community. The (NSSE) was administered to 179 students: 89 in an International College, 54 Chinese students and 36 Thai students, as a control. Our results showed different attitudes toward studying, teachers, memorisation, participation, critical thinking, and empathy. This paper concludes with a discussion of how students in an international university in Thailand arrange themselves socially, and why this matters.
Extension services can promote pasture restoration: Evidence from Brazil’s low carbon agriculture plan
Authors: Bragança Arthur , Newton Peter , Cohn Avery , Assunção Juliano , Camboim Cristiane , de Faveri Diego , Farinelli Barbara , Perego Viviana M.E. , Tavares Mateus , Resende Janei , de Medeiros Sidney , Searchinger Timothy D. 
Published: March 2022

Significance
Livestock supply chains account for 14.5% of global greenhouse gases (GHG) emissions. There is a consensus that approaches that improve cattle productivity while enhancing carbon sequestration can contribute to the multiple goals of improving ranchers’ livelihoods and mitigating climate change. Identifying policies that simultaneously increase productivity and sequestration is therefore critical to promote sustainable growth in the livestock sector. This paper documents the impact of training and technical assistance on pasture restoration and productivity in Brazil. We found that providing technical assistance to previously trained producers promoted pasture restoration, induced farmers to use more inputs, helped them improve their practices, and increased productivity and carbon sequestration. These findings highlight the importance of providing customized information to ranchers to help them sustainably intensify.
Elucidation of the key role of Pt···Pt interactions in the directional self-assembly of platinum(II) complexes
Authors: Zheng Xiaoyan , Chan Michael Ho-Yeung , Chan Alan Kwun-Wa , Cao Siqin , Ng Maggie , Sheong Fu Kit , Li Chu , Goonetilleke Eshani Chrisana , Lam William Wai Yan , Lau Tai-Chu , Huang Xuhui , Yam Vivian Wing-Wah 
Published: March 2022

Significance
Molecular self-assembly provides a bottom-up platform to design supramolecular functional materials, attracting numerous interests in material sciences. The utilization of platinum(II) complexes as building blocks of supramolecular assemblies opens up the unique noncovalent Pt···Pt interaction as one of the driving forces, imparting the supramolecular materials with rich spectroscopic features. However, the exact role of Pt···Pt interactions in molecular assembly remains elusive. The current study combines experimental and computational techniques to elucidate the role of Pt···Pt interactions in the self-assembly process of a representative amphiphilic platinum(II) complex. This work demonstrates the directional role of Pt···Pt interactions in assisting the molecular assembly in an anisotropic manner, achieving the formation of ordered self-assembled structures.
Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
Authors: Jin Chen , Wang Jiaoni , Wang Yumeng , Jia Bojun , Guo Xuefei , Yang Guanghui , Xu Peng , Greengard Paul , Zhou Rui , Shi Yigong 
Published: March 2022

Significance
γ-secretase activating protein (GSAP) has emerged as a key regulator of γ-secretase. In cells, GSAP exists primarily in the form of a 16-kDa fragment known as GSAP-16K. In this study, we report the finding that GSAP-16K undergoes phase separation in vitro and in cells. Importantly, the outcome of GSAP-16K phase separation directly regulates the protease activity of human γ-secretase. Through direct interaction with the substrate amyloid precursor protein–C-terminal 99-residue fragment, GSAP-16K in dilute phase favors the production of β-amyloid peptide 42 (Aβ42) but not Aβ40. These observations not only explain how GSAP activates γ-secretase but also identify their interaction as a target of potential therapeutic intervention.
Correspondences of matter field fluctuations in semiclassical and classical gravity in the decoherence limit
Authors: Satin Seema 
Published: March 2022

Abstract
A correspondence between fluctuations of non-minimally coupled scalar fields and that of an effective fluid with heat flux and anisotropic stresses, is shown. Though the correspondence between respective stress tensors of scalar fields and fluids is known and widely used in literature, the fluctuations in the two cases still await a formal correspondence and are open to investigation in all details. Using results obtained in the newly established theory of semiclassical stochastic gravity which focuses on the fluctuations of the quantum stress tensor, we show new relations in this regard. This development, apart from its relevance to the field-fluid correspondence, is expected to give insight to the mesoscopic phenomena for gravitating systems, and enable backreaction studies of the fluctuations on the perturbations of astrophysical objects. Such a development is aimed to enhance the perturbative analysis for cosmological spacetimes and astrophysical objects specifically in the decoherence limit. A kinetic theory, which can be based on stochastic fluctuations vs particle picture in curved spacetime may find useful insights from such correspondences in future work.
Light-enhanced gating effect at the interface of oxide heterostructure
Authors: Wadehra Neha , Tomar Ruchi , Yokoyama Yuichi , Yasui Akira , Ikenaga E , Wadati H , Maryenko Denis , Chakraverty S 
Published: March 2022

Abstract
In semiconducting materials, electrostatic gating and light illumination are widely used stimuli to tune the electronic properties of the system. Here, we show a significant enhancement of photoresponse at the conducting interface of LaVO3–SrTiO3 under the simultaneous application of light and negative gate bias voltage, in comparison to their individual application. On the other hand, the illuminated LaVO3-SrTiO3 interface does not show any enhancement, when a positive gate bias voltage is applied. Our x-ray diffractometer, Raman spectroscopy and photoemission measurements show that unlike the LaAlO3–SrTiO3 interface, migration of oxygen vacancies may not be the prime mechanism for the enhanced photoresponse. Rather, we suggest that the photoresponse of our system is intrinsic and this intrinsic mechanism is a complex interplay between band filling, electric field at the interface and modification of conducting channel width.
A label-free biomarkers detection platform relied on a bilayer long-wave infrared metamaterials BioNEMS sensor
Authors: Marvi Fahimeh , Jafari Kian 
Published: March 2022

Abstract
A novel approach based on optical Biological-Nano-Electro-Mechanical-Systems (BioNEMS) sensor is presented in this paper to provide highly sensitive and precise detection of biomolecules. The proposed BioNEMS sensor is relied on a bi-layer metamaterials structure, tuned by its wavelength. The presented biosensor consists of a BioNEMS membrane coated by Complementary Split Ring Resonators and an array of Split Ring Resonators cells on the substrate. While the immobilized bioreceptors adsorb the biomarkers (i.e. mRNA or protein), it causes a bending of the suspended membrane. This is due to the differential surface stress which is induced on the Nano-Electro-Mechanical-Systems structure. As a consequence, the coupling strength of two complementary metamaterial layers and thus the electromagnetic response of the biosensor are changed. Furthermore, the proposed device is designed and analyzed by numerical and analytical approaches in order to obtain its functional characteristics as follows: detection sensitivity of 21 967 nm/RIU, figure of merit of 327.8 RIU−1", mechanical sensitivity of 2.6 μm/Nm−1" and resonant frequency of 4.92 kHz. According to the obtained results, the functional characteristics of the proposed label-free biosensor show its high potential for highly sensitive and accurate molecule detections, disease diagnosis as well as drug delivery tests for Lab-On-Chip systems.
Synergistically segmenting choroidal layer and vessel using deep learning for choroid structure analysis
Authors: Zhu Lei , Li JunMeng , Zhu Ruilin , Meng Xiangxi , Rong Pei , Zhang Yibao , Jiang Zhe , Geng Mufeng , Qiu Bin , Rong Xin , Zhang Yadi , Gu Xiaopeng , Wang Yuwei , Zhang Zhiyue , Wang Jing , Yang Liu , Ren Qiushi , Lu Yanye 
Published: March 2022

Abstract

Objective. The choroid is the most vascularized structure in the human eye, whose layer structure and vessel distribution are both critical for the physiology of the retina, and disease pathogenesis of the eye. Although some works have used graph-based methods or convolutional neural networks to separate the choroid layer from the outer-choroid structure, few works focused on further distinguishing the inner-choroid structure, such as the choroid vessel and choroid stroma. Approach. Inspired by the multi-task learning strategy, in this paper, we propose a segmentation pipeline for choroid analysis which can separate the choroid layer from other structures and segment the choroid vessel synergistically. The key component of this pipeline is the proposed choroidal U-shape network (CUNet), which catches both correlation features and specific features between the choroid layer and the choroid vessel. Then pixel-wise classification is generated based on these two types of features to obtain choroid layer segmentation and vessel segmentation. Besides, the training process of CUNet is supervised by a proposed adaptive multi-task segmentation loss which adds a regularization term that is used to balance the performance of the two tasks. Main results. Experiments show the high performance (4% higher dice score) and less computational complexity (18.85 M lower size) of our proposed strategy. Significance. The high performance and generalization on both choroid layer and vessel segmentation indicate the clinical potential of our proposed pipeline.