bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health effects of reduced occupational sedentary behaviour in type 2 diabetes using a mobile health intervention: A study protocol for a 12-month randomized controlled trial – the ROSEBUD study
Authors: Syrjälä Maria Brännholm , Bennet L , Dempsey PC , Fharm E , Hellgren M , Jansson S , Nilsson S , Nordendahl M , Rolandsson O , Rådholm K , Ugarph-Morawski A , Wändell P , Wennberg P 
Published: May 2022

Abstract
Background
Short-term trials conducted in adults with type 2 diabetes mellitus (T2DM) showed that reducing sedentary behaviour by performing regular short bouts of light-intensity physical activity, enhances health. Moreover, support for reducing sedentary behaviour may be provided at a low cost via mobile health technology (mHealth). There are a wide range of mHealth solutions available including SMS text message reminders and activity trackers that monitor the physical activity level and notify the user of prolonged sitting periods. The aim of this study is to evaluate the effects of a mHealth intervention on sedentary behaviour and physical activity and the associated changes in health in adults with T2DM.
Methods
A dual-arm, 12-month, randomized controlled trial (RCT) will be conducted within a nationwide Swedish collaboration for diabetes research in primary health care. Individuals with T2DM (n = 142) and mainly sedentary work will be recruited across primary health care centres in five regions in Sweden. Participants will be randomized (1:1) into two groups. A mHealth intervention group who will receive an activity tracker wristband (Garmin Vivofit4), regular SMS text message reminders, and counselling with a diabetes specialist nurse, or a comparator group who will receive counselling with a diabetes specialist nurse only. The primary outcomes are device-measured total sitting time and total number of steps (activPAL3). The secondary outcomes are fatigue, health-related quality of life and musculoskeletal problems (self-reported questionnaires), number of sick leave days (diaries), diabetes medications (clinical record review) and cardiometabolic biomarkers including waist circumference, mean blood pressure, HbA1c, HDL-cholesterol and triglycerides.
Discussion
Successful interventions to increase physical activity amongst those with T2DM have been costly and long-term effectiveness remains uncertain. The use of mHealth technologies such as activity trackers and SMS text reminders may increase awareness of prolonged sedentary behaviour and encourage increase in regular physical activity. mHealth may, therefore, provide a valuable and novel tool to improve health outcomes and clinical management in those with T2DM. This 12-month RCT will evaluate longer-term effects of a mHealth intervention suitable for real-world primary health care settings.
Trial registration:
ClinicalTrials.gov Identifier: NCT04219800
The potential of Elophila obliteralis larvae (waterlily leafcutter moth) as a biological control for the invasive aquatic plant Nymphoides peltata (yellow floating heart)
Authors: Tomasko Rachael E , Jennrich Seth J , Gorbach Kathleen R , Warman Mark J 
Published: May 2022

Abstract
We tested the potential of Elophila obliteralis larvae (waterlily leafcutter moth, native to the eastern United States) as a biological control for Nymphoides peltata (yellow floating heart). N. peltata , an invasive aquatic floating-leaved plant in the United States, grows in mats creating profound shade reducing macrophyte community biodiversity below the water’s surface. The larvae cut pieces from its host plant’s foliage to live in and consume. It is hypothesized that the E. obliteralis larva has potential as a biological control for N. peltata ; as the density of larvae to leaf SA (surface area (cm 2 )) increases, a greater decline of leaf SA occurs. To determine the ability of the larvae to control the plant, different density ratios of larvae: leaf SA (1:8, 1:4, and no larva=control) were observed over 5 weeks, measuring the progression using Leafscan app. The higher density of larvae to leaf SA resulted in more foliage consumed. The treatments had a mean percent change ± standard deviation of +0.43% ± 22.26% SD (control), -40.37% ± 29.48% SD (1:8), and -71.27% ± 21.95% SD (1:4) from week 0-5. A one-way repeated measure ANOVA found a statistically significant difference among treatment groups (F= 10.51, p=0.002), indicating a significant effect of the larvae on plant SA. Observationally, the larvae impacted regrowth of the plant. These results indicate that E. obliteralis is a potential biological control for N. peltata . Future research should be conducted.
High-speed and efficient removal of Uranium (VI) from aqueous solution by hydroxyapatite modified ordered mesoporous carbon (CMK-3)
Authors: Ma Ming , Deng Hao , Ren Zhenyu , Zhong Xin 
Published: May 2022

Abstract
In recent years, the synthesis and application of green, cost-effective and sustainable materials for uranium (VI) removal was significant to environmental protection. The ordered mesoporous carbon (CMK-3) supported different mass of hydroxyapatite materials (HAP@CMK-3) were facilely synthesized via hydrothermal method. The resultant materials were characterized by XRD, FT-IR, BET, SEM, TEM-mapping and XPS, and implemented for immobilizing U(VI). Not only the specific surface area of HAP (7.01 m2/g) was increased by the loading on CMK-3 (818.37 m2/g), but also the adsorption capacity of CMK-3 was increased by HAP modification. Impressively, HAP@CMK-3 exhibited highly adsorption capacity of U(VI) with the increase of HAP deposition and was capable of achieving fast reaction. Therein to, the specific surface area of HAP@CMK-3(2:1) was 253.68 m2/g, as well as the adsorption capacity was up to 1072 mg/g (fitted by Langmuir isotherm, at pH = 3.0, 298 K) and the adsorption process was completed in 30 min (followed by pseudo-second-order kinetic). The adsorption mechanisms of U(VI) on HAP@CMK-3 involved electrostatic forces, ionic interactions and chemical complexation. This work offered new avenues to address the limitations of cost and less secondary pollution for the removal of U(IV) from wastewater.
A single-institution study comparing robotic major hepatectomy and laparoscopic major hepatectomy for hepatocellular carcinoma in terms of short-term outcomes
Authors: Liu Linsen , Wang Yan , Wu Tianchong , Lin Jianwei , Deng Lingna , Jiang Jiling , An Tailai 
Published: May 2022

Abstract
Background: Nowadays, more and more major hepatectomy surgeries for hepatocellular carcinoma (HCC) are being accomplished by robots. Despite the fact that robotic surgery has the potential of overcoming some disadvantages of laparoscopic procedures, studies comparing robotic major hepatectomy with laparoscopic major hepatectomy in terms of short-term results are still scarce. This study was performed to compare robotic major hepatectomy and laparoscopic major hepatectomy regarding intraoperative and postoperative results.Methods: Data of demographics, intraoperative and postoperative results of 131 patients undergoing robotic or laparoscopic major hepatectomy between January 2017 and March 2022 were retrieved from the medical records. Then patients undergoing robotic major hepatectomy were compared with those undergoing laparoscopic major hepatectomy in terms of demographic variables, intraoperative and postoperative results. Results: Between January 2017 and March 2022, 44 robotic major hepatectomy and 87 laparoscopic major hepatectomy were accomplished at Department of Hepatobiliary and Pancreatic Surgery, Shenzhen People,s Hospital. Firstly, patients undergoing robotic major hepatectomy were not significantly from those undergoing laparoscopic surgery in terms of age (P=0.397), gender (P=0.624), body mass index (BMI) (P=0.118), alpha-fetoprotein (AFP) (P=0.09), tumor size (P=0.176), cirrhosis (P=0.384), fatty liver (P=0.162), preoperative antiviral treatment (P=0.934), and HBV DNA (P=0.646). Secondly, it was revealed that patients undergoing robotic major hepatectomy were not significantly from those undergoing laparoscopic surgery in terms of length of hospital stay after operation (P=0.849), ICU stay (P=0.866), postoperative massive abdominal bleeding (P=1.00), portal vein thrombosis (P=1.00), abdominal infection (P=1.00), pulmonary infection (P=1.00), pulmonary embolism (P=1.00), cardiac complications (P=1.00), liver failure (P=1.00), kidney failure (P=1.00), biliary leak (P=1.00), 30-day mortality (P=1.00) and 90-day mortality (P=1.00). Thirdly, it was also demonstrated that it took significantly longer time to accomplish robotic major hepatectomy than that for laparoscopic major hepatectomy (P<0.001). Fourthly, the estimated blood loss during laparoscopic major hepatectomy was significantly more than that during robotic major hepatectomy (P=0.002). Conclusions: Robotic major hepatectomy was as effective as laparoscopic surgery in terms of intraoperative and postoperative variables and robotic surgery took longer time than laparoscopic surgery, while robotic approach could more efficiently control intraoperative blood loss.
Prediction Model of Sparse Autoencoder based Bidirectional LSTM for Wastewater Flow Rate
Authors: Huang Jianying , Yang Seunghyeok , Li Jinhui , Oh Jeill , Kang Hoon 
Published: May 2022

Abstract
Sanitary Sewer Overflows (SSO) caused by excessive Rainfall Derived Infiltration and Inflow (RDII) is the major challenge currently faced by municipal administrations, and therefore, the ability to correctly predict the wastewater state of the sanitary sewage system in advance is especially significant. In this paper, we present the design of the Sparse Autoencoder-based Bidirectional Long Short-Term Memory (SAE-BLSTM) network model, a model built on Sparse Autoencoder (SAE) and Bidirectional Long Short-Term Memory (BLSTM) networks to predict the wastewater flow rate in a sanitary sewer system. This network model consists of a data preprocessing segment, the Sparse Autoencoder (SAE) network segment, and the Bidirectional Long Short-Term Memory (BLSTM) network segment. The SAE is capable of performing data dimensionality reduction on high-dimensional original input feature data from which it can extract sparse potential features from the aforementioned high-dimensional original input feature data. The potential features extracted by the SAE hidden layer are concatenated with the smooth historical wastewater flow rate features to create an augmented previous feature vector that more accurately predicts the wastewater flow rate. These augmented previous features are applied to the BLSTM network to predict the future wastewater flow rate. Thus, this network model combines two kinds of abilities, SAE's low-dimensional nonlinear representation for original input feature data and BLSTM's time-series prediction for wastewater flow rate. We then conducted extensive experiments on the SAE-BLSTM network model utilizing the real-world hydrological time-series datasets. The experimental results show that our proposed SAE-BLSTM model consistently outperforms the advanced comparison models.
Evaluation of the Effect of Xylopia Aethiopica on the Hormonal Profile of Vertebrates
Authors: Nwankudu Oluchi Nnenna , Chibundu Amarachi Rejoice 
Published: May 2022

Abstract
Xylopia aethiopica is normally used as a major spice in pepper soup for post parturient women. Their spouses are advised to eat the nutrient-rich pepper soup with their wives. The aim of this study is to investigate how this spice affects the hormone profile of male and female vertebrates using albino rats. To do this, aqueous extraction of two varies of Xylopia was done and assessment of the compounds that comprise the two varieties was done. In vitro experiments to ascertain the effect of Xylopia on isolated rat uteri was considered necessary. Also, haematology and histopathology of the testis was also considered important. The two varieties of Xylopia used; Xylopia Ripe Fruit Extract (XRFE) and Xylopia Unripe Fruit Extract (XUFE) extracts were applied to strands of rats isolated uterine smooth muscle preparation in De Jalon solution and bubbled with air. In vivo, thirty rats of fourteen weeks of age were used. Fifteen males were divided into three groups of five each. Group A was control given 2ml/kg of distilled water while groups B and C were given XRFE and XUFE at a dose of 800mg/kg for thirty days. The fifteen females were divided into three as in males and treated accordingly. After thirty days, the rats in all the groups were sacrificed using mild ether for sedation and blood collected through cardiac puncture for haematology in heparinized bottles and serology in test tubes. Result: In vitro experimentations show that Xylopia relaxes the uterus in dose dependent manner. Hormonal profiling of the sera from in vivo experimentation in males revealed that Xylopia treatment reduces testosterone levels. The rate of testosterone reduction is more expressed in XRFE (P ≤ 0.01) treated than in XUFE (P ≤ 0.05) treated males. At the other hand, oestrogen secretion is significantly (P ≤ 0.01) enhanced in the females in XRFE treated females and significantly (P ≤ 0.05) reduced in XUFE treated females. Conclusion: Xylopia treatment in the females lead to induced secretion of oestrogen which suppresses the secretion of Mono Amine Oxidase thereby averting Post Parturient Depression (PPD) while in the males Xylopia treatment is postulated to be a handy male contraceptive. However more work should be done to confirm whether Xylopia treated males becomes temporarily infertile or not.
Effects of Prophylactic Antibiotic Administration and Antibiotic Timing on Culture Results and Clinical Outcomes of Pediatric Musculoskeletal Infection: A Protocol for A Randomized, Controlled, Clinical Trial
Authors: Xia Yongjie , Deng Chao , Zhou Yibiao , Wu Dechao , Liu Zhiyong , Xie Liangfu , E Bing , Han Jingming , You Chao 
Published: May 2022

Abstract
Background: Musculoskeletal infection (MSI) is a common cause of morbidity among the pediatric population. Some clinicians recommend withholding prophylactic antibiotics until culture collection with an aim to improve the culture sensitivity. However, a recent retrospective study reported that prophylactic antibiotic administration did not affect culture sensitivities in either disseminated or local MSI in pediatric population, which is surprising. Therefore, the aim of this study is to investigate the effects of prophylactic antibiotic administration and the timing of antibiotic administration on culture sensitivity and clinical outcomes of pediatric MSI.Methods: A randomized, controlled, clinical trial will be carried out. Individuals aged 0 to 18 years with a diagnosis of MSI will be screened and evaluated at the Shenzhen Children’s Hospital. The participants will be randomly allocated into four groups, and they will receive the antibiotic treatment at different time points, that is, 1 week, 3 days, 1 day prior to culture collection and 1 day after culture collection, respectively. The primary outcome will be culture sensitivity. In addition, the disease-related markers including white blood cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate, vital signs as well as the length of hospital stay will be measured or recorded accordingly. Using chi-squared tests, the rates of positive cultures will be compared between different groups. Statistical comparisons between the different patient groups regarding the confounding and outcome variables will be conducted using independent t-tests, Mann-Whitney U tests, chi-squared tests and Fisher’s exact tests as appropriate with the significance level set to 5% (P<0.05).Discussion: The results of this study would provide some evidence for the clinical management of pediatric MSIs with regards to the application of prophylactic antibiotics.Trial registration: Chinese Clinical Trial Registry, ChiCTR2100041631. Registered at 1 January 2021, http://www.chictr.org.cn/hvshowproject.aspx?id=69850.
Effects of Prophylactic Antibiotic Administration and Antibiotic Timing on Culture Results and Clinical Outcomes of Pediatric Musculoskeletal Infection: A Protocol for A Randomized, Controlled, Clinical Trial
Authors: Xia Yongjie , Deng Chao , Zhou Yibiao , Wu Dechao , Liu Zhiyong , Xie Liangfu , E Bing , Han Jingming , You Chao 
Published: May 2022

Abstract
Background
Musculoskeletal infection (MSI) is a common cause of morbidity among the pediatric population. Some clinicians recommend withholding prophylactic antibiotics until culture collection with an aim to improve the culture sensitivity. However, a recent retrospective study reported that prophylactic antibiotic administration did not affect culture sensitivities in either disseminated or local MSI in pediatric population, which is surprising. Therefore, the aim of this study is to investigate the effects of prophylactic antibiotic administration and the timing of antibiotic administration on culture sensitivity and clinical outcomes of pediatric MSI.
Methods
A randomized, controlled, clinical trial will be carried out. Individuals aged 0 to 18 years with a diagnosis of MSI will be screened and evaluated at the Shenzhen Children’s Hospital. The participants will be randomly allocated into four groups, and they will receive the antibiotic treatment at different time points, that is, 1 week, 3 days, 1 day prior to culture collection and 1 day after culture collection, respectively. The primary outcome will be culture sensitivity. In addition, the disease-related markers including white blood cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate, vital signs as well as the length of hospital stay will be measured or recorded accordingly. Using chi-squared tests, the rates of positive cultures will be compared between different groups. Statistical comparisons between the different patient groups regarding the confounding and outcome variables will be conducted using independent t-tests, Mann-Whitney U tests, chi-squared tests and Fisher’s exact tests as appropriate with the significance level set to 5% (P < 0.05).
Discussion
The results of this study would provide some evidence for the clinical management of pediatric MSIs with regards to the application of prophylactic antibiotics.
Trial registration
: Chinese Clinical Trial Registry, ChiCTR2100041631. Registered at 1 January 2021, http://www.chictr.org.cn/hvshowproject.aspx?id=69850.
Risky anatomical variations of sphenoid sinus and surrounding structures in endoscopic sinus surgery
Authors: Fadda Gian Luca , Petrelli Alessio , Urbanelli Anastasia , Castelnuovo Paolo , Bignami Maurizio , Crosetti Erika , Succo Giovanni , Cavallo Giovanni 
Published: May 2022

Abstract
Purpose: This study aimed to examine the relationship between the SS and surrounding vital structures such as the internal carotid artery (ICA) and optic nerve canal (ONC) as well as the types of attachment of the sphenoidal septa onto these structures.Methods: In total, 230 computed tomography (CT) scans were reviewed to study the type of sphenoid sinus pneumatization (SSP), the protrusion and dehiscence of the ICA and ONC, the relationship between the sphenoidal septa and surrounding vital structures as well as pterygoid recess pneumatization (PRP).Results: The most common SSP was sellar type (58.7%). The rates of protrusion and dehiscence of the ICA were 26.3% and 0.4%, and for the ONC, they were 13% and 1.5%, respectively. The ICA and ONC were most protruded and dehiscent in more extensive SSP. In 21.6% of patients, the intersphenoidal septa (IS) were attached to the wall of the ICA and in 8.6% they were attached to the wall of the ONC. The attachment of IS to the ICA correlated statistically significantly (p<0.0001) with protrusion of the ICA. Accessory septa were detected in 30.4% of cases with various sites of attachment.Conclusion: To reduce the risk of injury and complications during ESS, surgeons should consider using CT to identify possible bulging and dehiscence of the ICA/ONC and their relationship to the extent of SSP and also to establish the presence of deviation of the sphenoid septum, and the presence of accessory septa.
Prevalence of gestational diabetes in eastern Democratic Republic of Congo
Authors: Kisindja Rogatien Mwandjalulu , Tugirimana Pierrot Lundimu , Prudence Mitangala Ndeba , Bosunga Katenga , Sihalikyolo Jean-Jeannot Juakali , Kayamba Prosper Kalenga Muenze , A-Nkoy Albert Mwembo Tambwe- 
Published: May 2022

Abstract
Objective: To determine the prevalence of gestational diabetes and associated risk factors in the eastern region of the Democratic Republic of Congo (DRC).Methods: A cross-sectional study was conducted in Goma city, Idjwi, Ngungu and Rutshuru districts between April 2019 and February 2021. Were included, pregnant women between 24 to 28 weeks of amenorrhea who consented to participate in the study. Blood sugar, anthropometric parameters and obstetrical and family history were studied. Gestational diabetes was defined as blood glucose level between 92 and 125mg/dL.Results: The overall prevalence was 21.2% (n=391) and was higher in Rutshuru [27.2% (n=92)] and Goma [26.9% (n=134)] compared to Ngungu [10.0% (n=110)] (p=0.005). An increased risk was associated with a history of a newborn weighing ≥ 4000g [OR 2.4 95% CI (1.3 – 4.4)] or family diabetes [OR 2.9 95% CI (2.0 – 4.9)]. Median age in the pathological group was not different from that with normal blood glucose [25.0 (16.0 – 44.0) Vs 26.0 (16.0 – 44.0)] (p = 0.67). The prevalence tended to increase for pregnant women with a mid-upper arm circumference ≥ 280 mm [28.1% (n = 57)] Vs [19.3% (n=322)] if < 280 mm, [OR (95% CI)] [1.5 (0.9 - 2.3)] (p = 0.13).Conclusion: Gestattional diabetes was found in one out of five pregnant women regardless their age. The history of macrosomia birth and diabetes in the family were the main risk factors.
Enhanced production of withaferin A in hairy root cultures of underutilised plant Physalis minima L
Authors: HALDER TARUN , Ghosh Biswajit 
Published: May 2022

Abstract
Physalis minima L. is an important underutilised medicinal plant. It has many medicinal properties including anticancer activity due to the synthesis of steroidal lactone withaferin A. This is the first time we developed hairy root (HR) culture system via infection with wild A4 strain of Agrobacterium rhizogenes for continuous synthesis of steroidal lactone withaferin A. Maximum transformation efficiency (83.49 ± 2.45 %) was recorded with the treatment of 200 μM of acetosyringone. Confirmation of transformed root was analysed using seven different gene-specific primers. After the establishment of axenic culture, five different HR lines were separated and selected on the basis of their growth rate and accumulation of withaferin A (891.79 ± 36.21 μg g–1 DW) content analysed by standard high-performance liquid chromatography (HPLC) method. The present study investigated to enhance the biosynthesis of withaferin A by the application of different elicitors on selected HR lines. Elicitors like chitosan, yeast extract, salicylic acid, methyl jasmonate and aluminium chloride were examined. Among the different elicitors, all elicitors exhibit their positive response in differential manner with respect to withaferin A synthesis. The most effective response was observed when treated with elicitor methyl jasmonate and salicylic acid; they trigger to synthesise 18186.55 ± 45.46 μg g–1 DW and 19080.60 ± 58.04 μg g–1 DW of withaferin A, respectively from HR. After 15 d of culture, whereas controlled HR in MSO synthesised only 891.79 ± 36.21 μg g–1 DW of withaferin A content. Results suggested that HRs of P. minima open a new opportunity to produce enhanced amount of withaferin A after the treatment of elicitors.