bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers
Authors: Christiansen Colette , Tomlinson Max , Eliot Melissa , Nilsson Emma , Costeira Ricardo , Xia Yujing , Villicaña Sergio , Mompeo Olatz , Wells Philippa , Castillo-Fernandez Juan , Potier Louis , Vohl Marie-Claude , Tchernof Andre , Moustafa Julia El-Sayed , Menni Cristina , Steves Claire J. , Kelsey Karl , Ling Charlotte , Grundberg Elin , Small Kerrin S. , Bell Jordana T. 
Published: July 2022

Abstract
Background
There is considerable evidence for the importance of the DNA methylome in metabolic health, for example, a robust methylation signature has been associated with body mass index (BMI). However, visceral fat (VF) mass accumulation is a greater risk factor for metabolic disease than BMI alone. In this study, we dissect the subcutaneous adipose tissue (SAT) methylome signature relevant to metabolic health by focusing on VF as the major risk factor of metabolic disease. We integrate results with genetic, blood methylation, SAT gene expression, blood metabolomic, dietary intake and metabolic phenotype data to assess and quantify genetic and environmental drivers of the identified signals, as well as their potential functional roles.

Methods
Epigenome-wide association analyses were carried out to determine visceral fat mass-associated differentially methylated positions (VF-DMPs) in SAT samples from 538 TwinsUK participants. Validation and replication were performed in 333 individuals from 3 independent cohorts. To assess functional impacts of the VF-DMPs, the association between VF and gene expression was determined at the genes annotated to the VF-DMPs and an association analysis was carried out to determine whether methylation at the VF-DMPs is associated with gene expression. Further epigenetic analyses were carried out to compare methylation levels at the VF-DMPs as the response variables and a range of different metabolic health phenotypes including android:gynoid fat ratio (AGR), lipids, blood metabolomic profiles, insulin resistance, T2D and dietary intake variables. The results from all analyses were integrated to identify signals that exhibit altered SAT function and have strong relevance to metabolic health.

Results
We identified 1181 CpG positions in 788 genes to be differentially methylated with VF (VF-DMPs) with significant enrichment in the insulin signalling pathway. Follow-up cross-omic analysis of VF-DMPs integrating genetics, gene expression, metabolomics, diet, and metabolic traits highlighted VF-DMPs located in 9 genes with strong relevance to metabolic disease mechanisms, with replication of signals in FASN, SREBF1, TAGLN2, PC and CFAP410. PC methylation showed evidence for mediating effects of diet on VF. FASN DNA methylation exhibited putative causal effects on VF that were also strongly associated with insulin resistance and methylation levels in FASN better classified insulin resistance (AUC=0.91) than BMI or VF alone.

Conclusions
Our findings help characterise the adiposity-associated methylation signature of SAT, with insights for metabolic disease risk.
Severe dysphagia after a posterior cervical spine fusion at the C1–C3 level and its improvement after correction surgery for malalignment: a case report
Authors: Suvithayasiri Siravich , Decharin Payothorn 
Published: July 2022

Abstract
Background
The development of dysphagia and trismus following posterior C1–C3 fusion is rare compared to occipitocervical fusion, and there are very few reports in the literature.

Case presentation
A 75-year-old Thai man who had an extradural tumor at the C1/C2 level developed severe dysphagia and trismus immediately after tumor resection and C1–C3 fusion. During the surgery for malalignment correction, the C1–C2 screws were re-aligned into an increased lordotic position. The symptoms resolved immediately post-surgery.

Conclusions
Short upper cervical fusion can produce trismus and dysphagia in a relatively flexed position. Preoperative planning should be individualized based on the patient’s resting neutral alignment to prevent complications.
Sulfate-reducing bioreactors subjected to high sulfate loading rate or acidity: variations in microbial consortia
Authors: Salo Marja , Bomberg Malin 
Published: July 2022

AbstractSulfate-reducing bioreactors are used in e.g. the mining industry to remove sulfate and harmful metals from process waters. These bioreactors are expected to be run for extended periods of time and may experience variations in the influent quality, such as increasing sulfate loading rate and decrease in pH, while being expected to function optimally. In this study we followed the sulfate removal rate and variation in microbial communities over a period of up to 333 days in three different up-flow anaerobic sludge blanket (UASB) bioreactors being submitted to increasing sulfate loading rate or decreasing pH. Sodium lactate was used as the sole carbon source and electron donor. All three bioreactors contained highly diverse microbial communities containing archaea, fungi and bacteria. Sulfurospirillum and Desulfovibrio were the most prominent bacterial genera detected in the bioreactors receiving the highest sulfate loading rates, and the greatest relative abundance of methanogenic archaea and the fungal genus Cadophora coincided with the highest sulfate reduction rates. In contrast, Sulfuricurvum was dominant in the bioreactor receiving influent with alternating pH, but its relative abundance receded in response to low pH of the influent. All bioreactors showed excellent sulfate removal even under extreme conditions in addition to unique responses in the microbial communities under changing operational conditions. This shows that a high diversity in the microbial consortia in the bioreactors could make the sulfate removal process less sensitive to changing operational conditions, such as variations in influent sulfate loading rate and pH.
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
Authors: Sbardella Diego , Tundo Grazia Raffaella , Mecchia Alice , Palumbo Camilla , Atzori Maria Grazia , Levati Lauretta , Boccaccini Alessandra , Caccuri Anna Maria , Cascio Paolo , Lacal Pedro Miguel , Graziani Grazia , Varano Monica , Coletta Massimiliano , Parravano Mariacristina 
Published: July 2022

Abstract
Background
Diabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a dramatic burden for health and economic systems on a global scale. Although the pathogenesis of DR is largely unknown, several preclinical data have pointed out to a main role of Muller glia (MG), a cell type which spans across the retina layers providing nourishment and support for Retina Ganglion Cells (RGCs), in sensing hyper-glycemia and in acquiring a pro-inflammatory polarization in response to this insult.

Results
By using a validated experimental model of DR in vitro, rMC1 cells challenged with high glucose, we uncovered the induction of an early (within minutes) and atypical Nuclear Factor-kB (NF-kB) signalling pathway regulated by a calcium-dependent calmodulin kinase II (CamKII)-proteasome axis. Phosphorylation of proteasome subunit Rpt6 (at Serine 120) by CamKII stimulated the accelerated turnover of IkBα (i.e., the natural inhibitor of p65-50 transcription factor), regardless of the phosphorylation at Serine 32 which labels canonical NF-kB signalling. This event allowed the p65-p50 heterodimer to migrate into the nucleus and to induce transcription of IL-8, Il-1β and MCP-1. Pharmacological inhibition of CamKII as well as proteasome inhibition stopped this pro-inflammatory program, whereas introduction of a Rpt6 phospho-dead mutant (Rpt6-S120A) stimulated a paradoxical effect on NF-kB probably through the activation of a compensatory mechanism which may involve phosphorylation of 20S α4 subunit.

Conclusions
This study introduces a novel pathway of MG activation by high glucose and casts some light on the biological relevance of proteasome post-translational modifications in modulating pathways regulated through targeted proteolysis.
Emoji as promising tools for emotional evaluation in orthodontics
Authors: Marañón-Vásquez Guido Artemio , Maia Lucianne Cople , Barreto Luísa Schubach da Costa , da Cruz Mariana Farias , Jural Lucas Alves , Araújo Mônica Tirre de Souza , Pithon Matheus Melo 
Published: July 2022

Abstract
Background
Emoji are pictograms frequently used in social networks capable of expressing emotions. These tools can provide insights into people's behavior that could not be obtained with the use of textual communication. Recently, emoji have been introduced to various research fields as successful alternatives to word-based questionnaires for measure emotional responses. The objective of this study was to preliminarily evaluate the discriminating ability and relationship of these tools with different occlusal conditions/malocclusions.

Methods
Online surveys were applied to adult individuals (n = 201; mean age = 27.4 ± 5.7; 37.3% males, 62.7% females). Subjects issued acceptance scores (10-point scale) and expressed their emotional status using a 30-emoji list in relation to nine occlusal conditions: C1–crowding, C2–anterior open bite, C3–interincisal diastema, C4–increased overjet + deep bite (Class II div. 1), C5–anterior crossbite (Class III), C6–ideal occlusion, C7–unilateral posterior crossbite, C8–anterior open bite plus bilateral posterior crossbite plus crowding, and C9–deep bite (Class II div. 2). Cochran's Q and McNemar tests were used to compare the frequencies of choice of emoji between conditions. Correspondence analyses were applied to assess the association between occlusal conditions and emoji. Kendall's correlation coefficient was calculated to evaluate the relationship between mean acceptance scores and frequency counts of each emoji.

Results
The frequency of choice between conditions showed a significant difference for 25 of the 30 emoji (P < 0.05), indicating an adequate discriminating ability of these tools. Emoji were grouped predominantly based on their emotional valence (positive/negative) and arousal/activation (high/low). Positive emoji were associated with the most accepted conditions (i.e., C6, C3), while negative emoji with the most rejected ones (i.e., C8, C1, C2). Although only weak, positive correlations between acceptance and positively valenced emoji, and negative correlations between acceptance and negatively valenced emoji were observed (P < 0.05).

Conclusions
Emoji have an adequate discriminatory ability and would allow determining emotional profiles in the face of different occlusal conditions. Further research is necessary to consolidate the use of these tools in an instrument that allows measuring emotional responses.
68Ga-PSMA-11 PET/MRI versus multiparametric MRI in men referred for prostate biopsy: primary tumour localization and interreader agreement
Authors: Ferraro Daniela A. , Hötker Andreas M. , Becker Anton S. , Mebert Iliana , Laudicella Riccardo , Baltensperger Anka , Rupp Niels J. , Rueschoff Jan H. , Müller Julian , Mortezavi Ashkan , Sapienza Marcelo T. , Eberli Daniel , Donati Olivio F. , Burger Irene A. 
Published: July 2022

Abstract
Background
Magnetic resonance imaging (MRI) is recommended by the European Urology Association guidelines as the standard modality for imaging-guided biopsy. Recently positron emission tomography with prostate-specific membrane antigen (PSMA PET) has shown promising results as a tool for this purpose. The aim of this study was to compare the accuracy of positron emission tomography with prostate-specific membrane antigen/magnetic resonance imaging (PET/MRI) using the gallium-labeled prostate-specific membrane antigen (68Ga-PSMA-11) and multiparametric MRI (mpMRI) for pre-biopsy tumour localization and interreader agreement for visual and semiquantitative analysis. Semiquantitative parameters included apparent diffusion coefficient (ADC) and maximum lesion diameter for mpMRI and standardized uptake value (SUVmax) and PSMA-positive volume (PSMAvol) for PSMA PET/MRI.

Results
Sensitivity and specificity were 61.4% and 92.9% for mpMRI and 66.7% and 92.9% for PSMA PET/MRI for reader one, respectively. RPE was available in 23 patients and 41 of 47 quadrants with discrepant findings. Based on RPE results, the specificity for both imaging modalities increased to 98% and 99%, and the sensitivity improved to 63.9% and 72.1% for mpMRI and PSMA PET/MRI, respectively. Both modalities yielded a substantial interreader agreement for primary tumour localization (mpMRI kappa = 0.65 (0.52–0.79), PSMA PET/MRI kappa = 0.73 (0.61–0.84)). ICC for SUVmax, PSMAvol and lesion diameter were almost perfect (≥ 0.90) while for ADC it was only moderate (ICC = 0.54 (0.04–0.78)). ADC and lesion diameter did not correlate significantly with Gleason score (ρ = 0.26 and ρ = 0.16) while SUVmax and PSMAvol did (ρ =  − 0.474 and ρ =  − 0.468).

Conclusions
PSMA PET/MRI has similar accuracy and reliability to mpMRI regarding primary prostate cancer (PCa) localization. In our cohort, semiquantitative parameters from PSMA PET/MRI correlated with tumour grade and were more reliable than the ones from mpMRI.
Extracranial metastasis of recurrent glioblastoma to the parotid gland: a case report and review of the literature
Authors: Baskurt Ozan , Kurtulus Yunus , Yavuz Ahmed Yasin , Avci İdris 
Published: July 2022

AbstractBackgroundGlioblastomas are the most common and highly malignant primary brain tumors in adults with a median survival of 15 months even with appropriate treatment. Extracranial metastases are extremely rare due to the poor prognosis not allowing sufficient time to spread. We report an extremely rare case of extracranial metastasis of supra-tentorial glioblastoma involving the skin, subcutaneous and muscular layers, periauricular region and parotid gland, and review the literature. A total of 13 glioblastoma parotid gland metastases cases have been hitherto described.Main body of the abstractA 42-year-old man underwent surgery for right temporal glioblastoma and received 60 Gy/30 fractions radiotherapy together with temozolomide at 75 mg/m2. Seven months later, the tumor relapsed and the patient underwent a second surgery while chemotherapy continued. Fifteen months later, he complained of swelling in the right neck region. Fine needle aspiration and tru-cut biopsy revealed a high-grade malignant tumor infiltration within the parotid gland. Despite salvage chemotherapy and adjuvant radiotherapy, in his follow-up after 6 months neck swelling increased. The patient declined any treatment modality and continues his life 39 months after the primary diagnosis of intracranial glioblastoma.Short conclusionDue to the recurrence rate of intracranial glioblastoma and its malignant nature; close imaging follow-up is highly crucial. The increase in reported cases of its extracranial metastases is generally due to the modern diagnostic tools and prolonged survival attributed to the improvement in treatment modalities where now radical surgery with adjuvant radiotherapy and chemotherapy is standard protocol. Patients with glioblastomas presenting with swelling in the cervical region should be investigated to rule out parotid gland metastasis.
Directions to the Outskirts of Town: Punk Rock Tour Diaries from Nineties North America, Welly Artcore (2021)
Authors: Bestley Russ 
Published: July 2022

Review of: Directions to the Outskirts of Town: Punk Rock Tour Diaries from Nineties North America, Welly Artcore (2021)
Ticehurst: Earth Island Books, 316 pp.,
ISBN 978-1-83835-674-3, p/bk, GBP £14.99
Electric Wizards: A Tapestry of Heavy Music, 1968 to the Present, J. R. Moores (2021)
Authors: Paschos Yorgos 
Published: July 2022

Review of: Electric Wizards: A Tapestry of Heavy Music, 1968 to the Present, J. R. Moores (2021)
London: Reaktion Books Ltd, 480 pp.,
ISBN 978-1-78914-448-2, h/bk, GBP £20.00
Red Days: Popular Music & the English Counterculture 1965–1975, John Roberts (2020)
Authors: Erraught Stan 
Published: July 2022

Review of: Red Days: Popular Music & the English Counterculture 1965–1975, John Roberts (2020)
Colchester and New York: Minor Compositions, 197 pp.,
ISBN 978-1-57027-364-3, p/bk, GBP £18.00
PUNK! Las Américas Edition, Olga Rodríguez-Ulloa, Rodrigo Quijano and Shane Greene (eds) (2021)
Authors: Makagon Daniel 
Published: July 2022

Review of: PUNK! Las Américas Edition, Olga Rodríguez-Ulloa, Rodrigo Quijano and Shane Greene (eds) (2021)
Bristol: Intellect, 394 pp.,
ISBN 978-1-78938-415-4, h/bk, GBP £80.00
Faster! Louder! How a Punk Rocker from Yorkshire Became British Champion Fell Runner, Boff Whalley (2021)
Authors: Bestley Russ 
Published: July 2022

Review of: Faster! Louder! How a Punk Rocker from Yorkshire Became British Champion Fell Runner, Boff Whalley (2021)
Bradford: Great Northern Books, 232 pp.,
ISBN 978-1-91210-129-0, p/bk, GBP £9.99
Kinetic Modeling and Optimization of Biomass Gasification in Bubbling Fluidized Bed Gasifier Using Response Surface Method
Authors: Tulu Tolossa Kebede , Atnaw Samson Mekbib , Bededa Robera Daba , Wakshume Demeke Girma , Ancha Venkata Ramayya 
Published: July 2022

This paper presents the kinetic modeling of biomass gasification in bubbling fluidized bed (BFB) gasifiers and optimization methods to maximize gasification products. The kinetic model was developed based on two-phase fluidization theory. In this work, reaction kinetics, hydrodynamic conditions, convective and diffusion effect, and the thermal cracking of tar kinetics were considered in the model. The model was coded in MATLAB and simulated. The result depicted good agreement with experimental work in literature. The sensitivity analysis was carried out and the effect of temperature ranging from 650 to 850 and steam to biomass ratio (S/B) ranging from 0.1 to 2 was investigated. The result showed that an increase in temperature promoted H2 production from 18.73 % to 36.87 %, reduced that of CO from 39.97 % to 34.2 %, and CH4 from 18.01 % to 11.65 %. Furthermore, surface response was constructed from the regression model and the mutual effect of temperature and S/B on gasification products and heating value was investigated. In addition, the desirability function was employed to optimize gasification product and heating value. The maximum gasification product yield was obtained at 827.9 and 0.1 S/B. The response predicted by desirability function at these optimum operational conditions was 30.1 %, 44.1 %, 13.2 %, 12.9 %, 14.035 MJ/Nm3, and 14.5 MJ/Nm3 for H2, CO, CO2, CH4, LHV, and HHV, respectively. Kinetic modeling of the biomass gasification in BFB process is still under development, which considers the diffusion effect, tar cracking, reaction kinetics, and hydrodynamic behavior. Moreover, the large number of previous studies gave priority to a single parameter investigation. However, this investigation can be extended to various parameters analysis simultaneously, which would give solid information on system performance analysis.
Contrasts of urban development in Bauru city (SP): slum and fortified enclaves in Jardim Nicéia
Authors: Krause Anna B. P. , Goulart Jefferson O. 
Published: July 2022

The urban development of medium-sized cities in the interior of São Paulo state reproduced, to a large extent, the segregating logic of the Brazilian urbanization of large urban centers throughout the XX century. This paper analyzes the remarkable characteristics of the recent urbanization process in the city of Bauru (SP), relating them to the rise of precarious settlements in the form of the favela and the phenomenon of contemporary segregation in fortified enclaves. The object of analysis is the Jardim Nicéia slum, located between gated condominiums in the southern part of the city. The methodology used included a bibliographic review of theoretical and analytical references, research on demographic and socioeconomic data sources (IBGE, City Hall and municipal public agencies) and socio-spatial analysis of the area, in order to interpret how segregation is reproduced in this specific territorial area.
The cancer and its treatment and its impact on the patients’ life. A qualitative study
Authors: Gutiérrez Maria Gaby R de , Arthur Taís C , Fonseca Selma M da , Matheus Maria Clara C 
Published: July 2022

Background: Offering the best level of comfort and quality of life as possible is one of the goals of nursing care for cancer patients and their family, for both the diagnosis and the treatment of cancer still causes great apprehension and suffering. Purpose: Understanding the effects of cancer and its treatment on the different dimensions of the patients’ life. Methods: Descriptive study, developed under a qualitative approach, carried out from June to August 2005 with cancer patients of the Chemotherapy Ambulatory of the São Paulo Hospital, in São Paulo, Brazil. A semi-structured interview form was used for data collection and content analysis was applied in order to identify the thematic units. Results: Three themes emerged from patients’ reports: suffering the disease’s shock; re-dimensioning life; and feeling the need of a sensitive care. Conclusion: The results reinforce the need of implementing the humanization principles of nursing care when assisting cancer patients and their families.
Keywords: Oncology nursing; chemotherapy; nursing care; quality of life.
Leininger’s Theory and its use as framework for the professional practice in the nursing master’s dissertations at the UFSC. A preview note
Authors: Guesser Joice Cristina , Monticelli Marisa , Boehs Astrid Eggert , Gehrmann Taise , Paiva Kamila 
Published: July 2022

Abstract: Bibliographic study with the objective to identify and to analyze the master’s dissertations sustained at UFSC that had used Madeleine Leininger’s theory, raising its main characteristics, approaches and contrasts presented between the theory fundamentals and its operationalization. The data collection has begun in June 2006. Until now, the sample was characterized, the utilized concepts and its definitions were identified, as well as the methodological design. The next steps involve the correlation of the methodology with the theoretical framework, as well as the accomplishment of contrasts and approaches between the boarding theoretical-methodological approach utilized in the dissertations and the Leininger’s original proposal.
Keywords: Transcultural nursing; Nursing theory; Nursing research.
Fragilities and potentialities in the humanization attendance process in the intensive care unit: a qualitative and dialectic based-study
Authors: Pinho Leandro Barbosa de , Santos Silvia Maria Azevedo dos 
Published: July 2022

This study attempts to unveil difficulties and potentialities in the process of humanization attendance in the intensive care unit, from the speech of the intensive nursing, the perception of family members and interned patient. It is a qualitative, dialectic-based study involving 7 nurses, 4 family members, and 1 patient of the Adult ICU in the University Hospital of the Federal University of Santa Catarina, Brazil.
We evidence that the fragilities and potentialities in the humanization care process in the ICU involve a set of premises and factors, that if relate dialectically, going since the necessities most caregiver subjective and the well-taken care of being, until more structural dimensions, that if they around locate of the context and the spaces of performance. We think that reflection of the context of intensive attendance can help in the transformation of the reality, where professional that they take care of and well-taken care of people are in tunning, share experiences and limitations and, more of the one than this, they value the human potentials.