bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health service requirements after hospitalization due to COVID-19: a 1- year follow-up study
Authors: Andreo Jover J. , Vidal-Villegas M.P. , Mediavilla R. , Louzao Rojas I. , Cebolla Lorenzo S. , Fernández Jiménez E. , Muñoz-Sanjosé A. , Bravo-Ortiz M.F. , Martinez-Ales G. , Bayón-Pérez C. 
Published: September 2022

IntroductionLong-term COVID-19 effects has been recently described as persistent and prolonged symptoms after an acute and severe SARS-COV-2 (1). An important concern is that the sequelae of severe COVID-19 may suppose a substantial outpatient 's burden for the specialized services in reopening pandemic phase (2).ObjectivesTo describe the frequency of mental health service use in COVID-19 hospitalized patients after discharge and to estimate the costs associated to the post- discharge consultations.MethodsWe used a 1-year follow-up cohort of 1455 COVID-19 inpatients hospitalized in La Paz University Hospital of Madrid, Spain between March 16th and April 15th, 2020. Data were retrieved from Psychiatry Service (PS) electronic health records and we described the frequency of mental health reason for consultation. We used information published by the Madrid health Office to estimate the cost of initial and following appointments.ResultsOur sample consisted of 1,455 patients admitted with a COVID-19 diagnosis between March 16th and April 15th, 2020, and then discharged. Roughly half of them were men (776, 53%), 238 (16%) had a prior history of mental health problems, and 44 (3%) died. 193 participants (13%) visited the mental health department after being discharged. The total cost was estimated in 103,581 USD, of which two-thirds corresponded to patients with prior history of mental health problems.ConclusionsOur results indicate that the mental health burden of severe COVID-19 inpatient s after discharge was substantial during the first year of follow-up. This generate important economic impact to mental health providers and society at large.DisclosureNo significant relationships.
Benefits of treadmill training for patients with Down Syndrome
Authors: Kamińska K. , Ciołek M. , Krysta K. 
Published: September 2022

IntroductionDown syndrome (DS) is a complex condition that causes various health problems and it is accepted that treadmill training is a therapy method for some of them.ObjectivesThe objective was to evaluate the effectiveness of various results of treadmill training in children and adults with DS.MethodsWe included studies in which participants with DS from every age group received treadmill training, alone or combined with physiotherapy and could optionally be compared to a control group with patients with DS who did not use treadmill training. The search was conducted in medical databases: PubMed, PEDro, Science Direct, Scopus and Web of Science and involved trials published until July 2021. Following PRISMA criteria, the Risk of Bias assessment was conducted using a tool developed by the Cochrane Collaboration for RCT. The included studies presented multiple outcomes and various methodologies therefore we were not able to conduct any sort of data synthesis, we presented measures of treatment effect as mean differences and corresponding 95% confidence intervals.Results5 studies with a total number of 687 participants were included. 10 trials reported on walking onset, 8 on gait parameters or cardiovascular functions, 4 on anti-inflammatory effect and 3 on executive or cognitive functions. We came across 25 different outcomes in different age groups which are presented in a narrative manner. In all outcomes we have observed a positive result favouring the treadmill training.ConclusionsIntroducing treadmill exercise into typical physiotherapy generates improvements of mental and physical health of people with DS of all ages.DisclosureNo significant relationships.
Clinical effects of central antagonist of cholecystokinin-1 receptors GB-115 in patients with Generalized Anxiety Disorder
Authors: Dorofeeva O. , Syunyakov T. , Metlina M. , Ivashkina N. 
Published: September 2022

Introduction
The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily. Here, we provide results of post-hoc analysis of changes of anxiety and fatigue symptoms to give characterization of its clinical effects in clinically relevant doses.ObjectivesTo research the changes of anxiety- and fatigue-related symptoms during GB-115 treatment in patients with generalized anxiety disorder (GAD).Methods

Patients with GAD without somatic diseases aged 18-55 years were eligible in the study. Patients were prescribed with GB-115 6 mg daily for 21 days. Anxiety and fatigue symptoms were assessed with Hamilton Anxiety Rating Scale (HARS) and Multidimensional Fatigue Inventory (MFI-20). Variables are described as medians and interquartile range (IQR). Pre-post comparisons were performed using the Friedman ANOVA at 2-side p-value <0.05.Results25 patients diagnosed with GAD (8 males, 17 females; median [IQR] age: 34 [29.75, 43.0]) included in the analysis. Median [IQR] HARS total score decreased from 22 [20, 24.5] to 19 [16, 20], 13 [10.5, 15.5], 9 [5.5, 11] and 5 [3.5, 8] on the Day 3,7,14 and 21, respectively (χ2=95.07, df=4, p<0.001). Median [IQR] MFI-20 score decreased from 70 [46, 75.5] to 59 [41, 74.5], 52 [37.5, 64.5], 37 [26.5, 63] and 28 [24, 48.5] on the Day 3, 7, 14 and 21, respectively (χ2= 55.41, df=4, p<0.001). None of patients had stimulation-related side effects.ConclusionsGB-115 action in the treatment of GAD patients is characterized with anxiolytic action with mild psychostimulant properties.DisclosureNo significant relationships.
The multimodal psychotherapy of the anxiety disorders patients
Authors: Mykhaylov B. , Kudinova O. 
Published: September 2022

IntroductionContemporary anxiety disorders are the main medical problem.ObjectivesOn the basis of complex psychopatological, pathopsychological research, were obtained reasons and conditions of formation, psychopathological structure, syndrome peculiarities, emotional disfunctions of patients on episodic paroxismal and generalized anxiety disorders and mixed anxiously depressed disorders.MethodsThe basic method was a group psychotherapy with the elements of rational, positive, suggestive and family psychotherapy. In relation to disfunctions of emotional sphere, CBT was used for the phobic-depressive and anxious-depressive syndroms.Results180 anxiety disorders patients were examined, by the stationary course of treatment.Decrease of general level of anxiety and internal anxiety was obtained for most patients. No spontaneous emergence of fear was practically observed. While active interviewing, patients stated that their former worries and fears have lost actuality and apparent emotional colouring become. Considerable reduction of symptomatic of the depressed circle also took place, patients started to feel joy and optimism.ConclusionsTo correct emotional disfunction of patients with episodic paroxismal disorders, generalized anxiety disorders and mixed anxiously depressed disorders, psychotherapeutic correction system is optimal to use, which is built based on stepwise and multimodal principles.DisclosureNo significant relationships.
Medical residents and COVID-19
Authors: Jomli R. , Jemli H. , Ouali U. , Maktouf A. , Zgueb Y. , Aissa A. 
Published: September 2022

IntroductionThe covid-19 pandemic is a difficult global phenomenon that causes a lot of anxiety and uncertainty. This situation has involved reactions of fear. Healthcare professionals are necessarily in contact with patients, but may find themselves torn between the duty to care and the duty to protect themselves and their relatives.ObjectivesTo assess perceived stress among medical residents in TunisiaMethodsWe conducted a descriptive study among a representative sample of residents working at a teaching hospital in Tunis during the first half of 2021 in different departments. We prepared a questionnaire for the study divided in two parts: socio-demographic data; professional data (function, practice setting); data related to contact with covid-19 patients ; questions on fear of covid-19 contamination and the Perceived stress scale (10items)ResultsOur sample consists of 100 residents in 10 different specialties, including 70 in services with direct contact with Covid-19 patients. Stress management is rated good for 30 residents, average for 40 residents and poor for 30 residents. This management depends on the number of guards, the number of patients examined, the technical platform available and especially the period of the pandemic.ConclusionsMedical residents are in the front line in university hospitals in tunisia. The stress to which they are subjected depends on the working conditions and coping skills of each of them.DisclosureNo significant relationships.
Cognitive function in female patients with chronic functional constipation
Authors: Morozova M. , Rupchev G. , Alexeev A. , Beniashvili A. , Potanin S. , Burminskiy D. , Lepilkina T. 
Published: September 2022

IntroductionChronic functional gastro-intestinal disorders can affect cognitive functioning of patients (1). Wong et al (2) showed attentional and executive function impairment, Aizawa et al. (3) found impairment of cognitive plasticity and activity of frontal and temporal arias of brain during performing tests in these patients.ObjectivesAssessing of cognitive functioning of the female patients with chronic functional constipation.Methods42 Rome IV adult female patients with chronic functional constipation and 26 adult normative female volunteers were tested with Brief Assessment of Cognition in Schizophrenia (BACS).ResultsBoth groups were comparable by age (patients’ group 29,5±6,1, volunteers’ group 28,5±9,6, ns) In both groups subjects demonstrated normal level of cognitive functioning but the scores of the patients were closer to the lower level than the scores of the volunteers. The difference was significant in composite scores and in several other scores (Tab.1). Table1.BACSPatients (n=42)Volunteers (n=26)p-levelVerbal Memory49,5± 10,658,8± 7,10,0002Work memory48,2±10,151,7±8,4nsMotor token51,3±10,559,8±10,40,003Verbal fluency52,1±11,556,5±9,9nsSymbol coding45,1±8,454,8±12,70,015Tower of London (planning)50,2±10,757,6±10,20,015Composite scores49,1 ±10,159,9 ±7,40,0001ConclusionsThe findings of the study once more indicate some link between gastrointestinal dysfunction and cognitive functioning. Even these slight decrease in some aspects of cognition from normal population could have negative impact on everyday functioning. The origin of this link is still under question.DisclosureNo significant relationships.
Thyroid Function Rather Than Thyroid Antibodies Affects Pregnancy and Perinatal Outcomes: Results of a Prospective Study
Authors: Orsolini Francesca , Gianetti Elena , Terrenzio Chiara , Montanelli Lucia , Benelli Elena , Bagattini Brunella , Fiore Emilio , Tonacchera Massimo 
Published: September 2022

Abstract

Context
Thyroid autoantibody positivity has been associated with an increased rate of obstetrical complications.

Objective
We aimed to evaluate the role of thyroid autoantibodies in adverse pregnancy outcomes.

Methods
This prospective study was conducted in the Endocrinology Unit of Pisa Hospital. A total of 975 pregnant women were studied from 2012 to 2021; 572 (59%) were diagnosed with autoimmune thyroid (AT) diseases; 403 (41%) served as controls. Levothyroxine (LT4) treatment was introduced when TSH was &gt; 2.5 mIU/L in the AT group and when TSH was &gt; 4 mIU/L in the controls. Rates of obstetrical complications in each group were measured.

Results
Although the frequency of miscarriage in the AT group was greater (4.8%) than in the controls (2.9%), no significant differences were detected (P = 0.181). There were no differences between the 2 groups concerning the other pregnancy complications, and no association with the titer of thyroid antibodies was observed. The frequency of congenital malformations was greater in the AT group than in the controls (P = 0.019), but no correlation with major congenital malformations was detected (P = 0.872). Given that thyroid hormone concentrations were strictly controlled in our population, we documented a tendency (not significant) toward an increase in miscarriage and preterm birth among women with TSH &gt; 4 mIU/L.

Conclusion
If thyroid function is adequately controlled, the presence and titer of thyroid autoantibodies does not negatively influence gestation. Although not significant, suboptimal thyroid hormone status seems to affect pregnancy outcomes more than thyroid autoimmunity.
The atypical small GTPase RABL3 interacts with RAB11 to regulate early ciliogenesis in human cells
Authors: Kobayashi Tetsuo , Ikeda Tatsuya , Ota Reo , Yasukawa Takafumi , Itoh Hiroshi 
Published: September 2022

ABSTRACT
Primary cilia are near-ubiquitously assembled on cells in the human body, and are broadly associated with genetic diseases and cancers. In the early stage of ciliogenesis, the ciliary vesicle (CV) is formed on the mother centriole, which nucleates the primary cilium. However, the regulatory mechanisms underlying CV formation have not yet been fully elucidated. Here, we found that the atypical small GTPase RAB-like 3 (RABL3) is necessary to assemble primary cilia in human cells. RABL3 directly interacts with RAB11 (herein referring to both RAB11A and RAB11B), which is involved in CV formation. RABL3 localizes around the centrosome during early ciliogenesis, reminiscent of RAB11 dynamics. Furthermore, RABL3 positively controls the CV formation like RAB11. These findings suggest that RABL3 plays an important role, in cooperation with RAB11, in CV formation during early ciliogenesis.
Expert clinical consensus in the delivery of hydrodilatation for the management of patients with a primary frozen shoulder
Authors: Thompson Helen , Brealey Stephen , Cook Elizabeth , Hadi Saif , Khan Shah H. M. , Rangan Amar 
Published: September 2022

Aims To achieve expert clinical consensus in the delivery of hydrodilatation for the treatment of primary frozen shoulder to inform clinical practice and the design of an intervention for evaluation. Methods We conducted a two-stage, electronic questionnaire-based, modified Delphi survey of shoulder experts in the UK NHS. Round one required positive, negative, or neutral ratings about hydrodilatation. In round two, each participant was reminded of their round one responses and the modal (or ‘group’) response from all participants. This allowed participants to modify their responses in round two. We proposed respectively mandating or encouraging elements of hydrodilatation with 100% and 90% positive consensus, and respectively disallowing or discouraging with 90% and 80% negative consensus. Other elements would be optional. Results Between 4 August 2020 and 4 August 2021, shoulder experts from 47 hospitals in the UK completed the study. There were 106 participants (consultant upper limb orthopaedic surgeons, n = 50; consultant radiologists, n = 52; consultant physiotherapist, n = 1; extended scope physiotherapists, n = 3) who completed round one, of whom 97 (92%) completed round two. No elements of hydrodilatation were “mandated” (100% positive rating). Elements that were “encouraged” (≥ 80% positive rating) were the use of image guidance, local anaesthetic, normal saline, and steroids to deliver the injection. Injecting according to patient tolerance, physiotherapy, and home exercises were also “encouraged”. No elements were “discouraged” (≥ 80% negative rating) although using hypertonic saline was rated as being “disallowed” (≥ 90% negative rating). Conclusion In the absence of rigorous evidence, our Delphi study allowed us to achieve expert consensus about positive, negative, and neutral ratings of hydrodilatation in the management of frozen shoulder in a hospital setting. This should inform clinical practice and the design of an intervention for evaluation. Cite this article: Bone Jt Open 2022;3(9):701–709.
DESENVOLVIMENTO MUNICIPAL NAS MESORREGIÕES DIFERENCIADAS DA AMAZÔNIA OCIDENTAL
Authors: Almeida Freitas Lara Brunelle , Ferrera de Lima Jandir 
Published: September 2022

Esse artigo analisa a atratividade e a disparidade no desenvolvimento socioeconômico dos municípios que compõem as Mesorregiões Diferenciadas Alto do Solimões e Vale do Rio Acre, ambas localizadas na área ocidental do espaço da Amazônia legal brasileira. A metodologia utilizada foi a estimativa dos índices de centralidade e disparidade regional a partir de dados da população, de crescimento e desenvolvimento socioeconômico. Os resultados demonstraram que os municípios melhoraram seus indicadores de desenvolvimento humano, mas ainda não conseguiram avançar em emprego e renda. A convergência dos indicadores socioeconômicos foi positiva, mas a centralidade dos municípios centrais continua bem significativa.
Computational microscopy for fast widefield deep-tissue fluorescence imaging using a commercial dual-cannula probe
Authors: Mitra Ekata , Guo Ruipeng , Nelson Soren , Nagarajan Naveen , Menon Rajesh 
Published: September 2022

A solid-glass cannula serves as a micro-endoscope that can deliver excitation light deep inside tissue while also collecting emitted fluorescence. Then, we utilize deep neural networks to reconstruct images from the collected intensity distributions. By using a commercially available dual-cannula probe, and training a separate deep neural network for each cannula, we effectively double the field of view compared to prior work. We demonstrated ex vivo imaging of fluorescent beads and brain slices and in vivo imaging from whole brains. We clearly resolved 4 µm beads, with FOV from each cannula of 0.2 mm (diameter), and produced images from a depth of ∼1.2 mm in the whole brain, currently limited primarily by the labeling. Since no scanning is required, fast widefield fluorescence imaging limited primarily by the brightness of the fluorophores, collection efficiency of our system, and the frame rate of the camera becomes possible.
Lipid lowering therapy patterns and the risk of cardiovascular events in the 1-year after acute myocardial infarction in United Arab Emirates
Authors: Pinto Lionel , Farghaly Mohamed , Nunna Sasikiran , Chickballapur Ramachandrachar Badarinath , Chilukuri Sri Harshadeep , Natarajan Ashok 
Published: September 2022

Aim
In United Arab Emirates, cardiovascular disease (CVD) is a leading cause of mortality and 22% of CVD deaths are attributable to acute myocardial infarction (MI). Adherence to guidelines for lipid management is incompletely described in the Middle East. This study aimed to characterize lipid lowering therapy (LLT) patterns and the risk of subsequent cardiovascular events (CVEs) in the first year after MI.

Methods
This was a retrospective cohort study using the Dubai Real-World Claims Database, including all patients discharged with MI between January 01, 2015 and December 31, 2018, followed-up until December 31, 2019.

Results
In the first year after MI, 8.42% of 4,595 patients included experienced at least one recurrent MI (rate 6.77 events/100 person-years [PYs]), 2.94% had one revascularization (cumulative rate 0.55 events/100 PYs) and 2.66% had one hospitalization due to unstable angina (cumulative rate 5.16 new events/100 PYs). The majority (60.40%) of the patients presented with LDL-C levels ≥ 70 mg/dL after MI. In the first year after MI, 93.45% of the patients received LLT, mainly high-intensity statin (67.79%); with a minority of patients receiving statin + ezetimibe (4.55%), PCSK9i (0.20%) or ezetimibe alone (0.07%).

Conclusion
Patients hospitalized with MI in Dubai present an increased risk of CVEs in their first-year post-discharge. Majority of the patients presented with LDL-C levels above 70 mg/dL, which indicates suboptimal lipid control with existing LLT, particularly in high-risk patients.
Disparities in scientific research activity between doctors and nurses working in the Peruvian health care system: Analysis of a nationally representative sample
Authors: Vergara-Mejía Angélica , Niño-Garcia Roberto , Zeta-Solis Ludwing , Soto-Becerra Percy , Al-kassab-Córdova Ali , Pereyra-Elías Reneé , Cabieses Báltica , Mezones-Holguin Edward 
Published: September 2022

AimTo evaluate disparities in the frequency of scientific activity between medical doctors and nurses in Peru.MethodsWe carried out a secondary data analysis of the National Health Services Users’ Satisfaction Survey (ENSUSALUD), 2016. This nationally representative survey evaluates doctors and nurses working in clinical settings. We defined scientific activity as i) having published an original article (journal indexed in Web of Science, Scopus or Medline); and ii) having authored an abstract in a national or international conference. We estimated crude and adjusted disparities prevalence ratios (aDPR) and 95% confidence intervals (95%CI).ResultsWe included 2025 doctors and 2877 nurses in the analysis; 71% of doctors doctor were male, and 93% of nurses were female (p<0.001). Among doctors, 13.9% had published an article, and 8.4% presented an abstract at a conference in the last two years, while these proportions were 0.6% and 2.5% for nurses, respectively. The adjusted models showed that doctors, when compared to nurses, were approximately 27 times likely to have published a paper (aDPR = 27.86; 95% CI 10.46 to 74.19) and twice as likely to have authored a conference abstract (aDPR = 2.51; 95% CI 1.39 to 4.53).ConclusionsThere are important disparities in scientific activity between doctors and nurses working in clinical settings in Peru. Disparities are more significant for article publication than for authoring in conference abstracts. We suggest public policies that promote research dissemination between health professionals, with emphasis on nurses.
Clinical phenotypes of delirium in patients admitted to the cardiac intensive care unit
Authors: Ko Ryoung-Eun , Kim Sungeun , Lee Jihye , Park Sojin , Bae Daehwan , Choi Ki Hong , Park Taek Kyu , Chung Chi Ryang , Yang Jeong Hoon 
Published: September 2022

Background
Limited data are available on clinical phenotype for delirium that occurs frequently among patients admitted to the cardiac intensive care unit (CICU). The objective of this study was to investigate the clinical pictures of delirium, and their association with clinical outcomes in CICU patients.

Methods
A total of 4,261 patients who were admitted to the CICU between September 1 2012 to December 31 2018 were retrospectively registered. Patients were excluded if they were admitted to the CICU for less than 24 hours or had missed data. Ultimately, 2,783 patients were included in the analysis. A day of delirium was defined as any day during which at least one CAM-ICU assessment was positive. The clinical risk factors of delirium were classified by the delirium phenotype, as follows; hypoxic, septic, sedative-associated, and metabolic delirium.

Results
The incidence of delirium was 24.4% at the index hospitalization in all CICU patients, and 22.6% within 7 days after CICU admission. The most common delirium phenotype was septic delirium (17.2%), followed by hypoxic delirium (16.8%). Multiple phenotypes were observed during most delirium days. Delirium most frequently occurred in patients with heart failure. Of all patients affected by delirium within 7 days, both ICU and hospital mortality significantly increased according to the combined number of delirium phenotypes.

Conclusions
Delirium occurred in a quarter of patients admitted to the modern CICU and was associated with increased in-hospital mortality. Therefore, more efforts are needed to reduce the clinical risk factors of delirium, and to prevent it in order to improve clinical outcomes in the CICU.