bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Iron-Inflammation Axis in Early-Stage Triple-Negative Breast Cancer
Authors: Duan Fangfang , Zhong Muyi , Ye Jinhui , Wang Li , Jiang Chang , Yuan Zhongyu , Bi Xiwen , Huang Jiajia 
Published: February 2022

The iron-related homeostasis and inflammatory biomarker have been identified as prognostic factors for cancers. We aimed to explore the prognostic value of a novel comprehensive biomarker, the iron-monocyte-to-lymphocyte ratio (IronMLR) score, in patients with early-stage triple-negative breast cancer (TNBC) in this study. We retrospectively analysed a total of 257 early-stage TNBC patients treated at Sun Yat-sen University Cancer Center (SYSUCC) between March 2006 and October 2016. Their clinicopathological information and haematological data tested within 1 week of the diagnosis were collected. According to the IronMLR score cutoff value of 6.07 μmol/L determined by maximally selected rank statistics, patients were stratified into the low- and high-IronMLR groups, after a median follow-up of 92.3 months (95% confidence interval [CI] 76.0–119.3 months), significant differences in 5-years disease-free survival (DFS) rate (81.2%, 95% CI 76.2%–86.5% vs. 65.5%, 95% CI 50.3%–85.3%, p = 0.012) and 5-years overall survival (OS) rate (86.0%, 95% CI 81.6%–90.7% vs. 65.5%, 95% CI 50.3%–85.3%, p = 0.011) were seen between two groups. Further multivariate Cox regression analysis revealed the IronMLR score as an independent predictor for DFS and OS, respectively, we then established a prognostic nomogram integrating the IronMLR score, T stage and N stage for individualized survival predictions. The prognostic model showed good predictive performance with a C-index of DFS 0.725 (95% CI 0.662–0.788) and OS 0.758 (95% CI 0.689–0.826), respectively. Besides, calibration curves for 1-, 3-, 5-DFS, and OS represented satisfactory consistency between actual and nomogram predicted survival. In conclusion, the Iron-inflammation axis might be a potential prognostic biomarker of survival outcomes for patients with early-stage TNBC, prognostic nomograms based on it with good predictive performance might improve individualized survival predictions.
HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas
Authors: Zhou Xiang , Ji Qiankun , Li Qin , Wang Peng , Hu Guowen , Xiao Feng , Ye Minhua , Lin Li , Luo Min , Guo Yun , Wu Weijun , Huang Kai , Guo Hua 
Published: February 2022

Gliomas are primary intracranial space lesions with a high mortality rate. Current treatments for glioma are very limited. Recently, immunotargeted therapy of the glioma microenvironment has been developed. Members of the 70 kDa heat shock protein (HSP70) family are involved in the development of many tumors and immunity. HSPA6 protein belongs to the HSP70 family; However, the biological function of this protein in gliomas has yet to be evaluated. In the present study, a range of analyses, involving protein networks, survival, clinical correlation, and function, revealed that the expression of HSPA6 was negatively correlated with clinical prognosis and closely associated with immunity, invasion, and angiogenesis. Quantitative protein analysis confirmed that HSPA6 was expressed at high levels in patients with glioblastoma. Vitro experiments further verified that HSPA6 enhanced the malignant progression of glioma cells by promoting proliferation, invasion and anti-apoptosis. We also found that HSPA6 was closely correlated with genomic variations and tumor microenvironment. Collectively, we demonstrated that HSPA6 may represent a new therapeutic target to improve the prognosis of patients with gliomas.
Comparison of Single Axillary vs. Dual Arterial Cannulation for Acute Type a Aortic Dissection: A Propensity Score Matching Analysis
Authors: Chang Yi , Lin Hongyuan , Qian Xiangyang , Guo Hongwei , Yu Cuntao , Sun Xiaogang , Wei Bo , Ma Qiong , Wei Yizhen , Shi Yi 
Published: February 2022

BackgroundThe optimal arterial cannulation site for acute aortic dissection repair is unclear, especially for complex arch surgery. Axillary artery cannulation is widely accepted but adding femoral artery cannulation to it was considered to potentially improve perfusion and early outcomes. To clarify this point, a comparison of perioperative outcomes for these two different cannulation strategies was conducted regarding the pathological features of dissection.MethodsFrom January 2010 to December 2019, 927 consecutive patients underwent a total arch replacement combined with frozen elephant trunk for acute type A aortic dissection. The data, including detailed pathological features, were retrospectively collected and analyzed. Propensity score matching and multivariate logistic regression analysis were used for adjusting confounders that are potentially related to the outcome.ResultsA total of 523 patients (56.3%) accepted a dual arterial cannulation (DAC group), and 406 patients (43.7%) received a single axillary artery cannulation (SAC group). In total, 388 pairs of patients were well-matched. Whether before or after adjusting the preoperative characteristics by matching, there were no significant differences in operative mortality (6.7 vs. 5.4%, P = 0.420 before matching; 5.4 vs. 5.4%, P = 1 after matching), stroke (6.7 vs. 5.4%, P = 0.420 before matching; 6.4 vs. 5.2%, P = 0.435 after matching), spinal cord injury (5 vs. 5.7%, P = 0.640 before matching; 5.4 vs. 5.7%, P = 1. After matching), and acute renal failure requiring dialysis (13.8 vs. 9.6%, P =0.050 before matching; 12.6 vs. 9.5%, P = 0.174) between the two groups. Dual arterial cannulation was not an independent protective factor of operative mortality (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.55–1.86), stroke (OR 1.17, 95% CI 0.65–2.11), spinal cord injury (OR 1.17, 95% CI 0.65–2.11), and acute renal failure requiring continuous renal replacement therapy (CRRT) (OR 1.24, 95% CI 0.78–1.97) after adjusting for confounding factors by multivariable logistic regression analysis. In the subgroup analysis, no advantage of dual arterial cannulation was found for a particular population.ConclusionsSingle axillary artery cannulation was competent in the complex arch repair for acute aortic dissection, presenting with a satisfactory result as dual arterial cannulation. Adding femoral artery cannulation was necessary when a sufficient flow volume could not be achieved by axillary artery cannulation or when a lower limb malperfusion existed.
Feasibility of Apatinib in Radioiodine-Refractory Differentiated Thyroid Carcinoma
Authors: Du Wei , Shi Xiangyu , Fang Qigen , Zhang Xu , Liu Shanting 
Published: February 2022

ObjectivesOur aim was to describe our experience in using apatinib as treatment for radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC).MethodsForty-seven patients undergoing apatinib treatment for RAIR-DTC were prospectively enrolled in this study. The study endpoints were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and rate of adverse events.ResultsNo patients achieved complete response, while 36 (76.6%) and 8 (17.0%) patients achieved partial response and stable disease, respectively. The ORR and DCR were 76.6% and 93.6%, respectively. The median PFS and OS were 18 and 59 months, respectively. A total of 91 adverse events occurred, of which 21 were graded as grade 3 or higher. There were no drug-related deaths.ConclusionsApatinib has distinct anti-RAIR-DTC efficacy in terms of ORR, PFS, and OS and has a favorable safety profile. It is a feasible treatment option for RAIR-DTC.
The Effect of the Milling Vial Shape on the In-Situ Consolidation of a Nanocrystalline Al-Li-GNPs Nanocomposite Synthesized by Room Temperature Ball-Milling
Authors: Ahmad Sara I. , Youssef Khaled M. 
Published: February 2022

Several studies investigating the ball-milling of ductile face-centered cubic metals have reported a so-called in-situ consolidation phenomenon where the milled powder is also consolidated during the milling process. Thus, instead of refined powders or agglomerated particles, the formation of spherical bulk particles of the milled material is reported using a combination of cryomilling and room temperature milling processes. In this study, we studied the effect of the milling vial shape on the in-situ consolidation of a graphene nanoplatelets (GNPs) reinforced aluminum-lithium (Al-Li) matrix nanocomposite for the first time. An in-situ consolidated nanometric Al-Li-GNPs nanocomposite with an average grain size of 48 nm and high hardness of 1.48 GPa was attained after only 8 h of room-temperature milling. The results presented suggest that dense nanostructured composites can be prepared by in-situ consolidation during a one-step milling process and subsequently investigated in order to analyze their mechanical behavior. This allows for the intrinsic mechanical behavior of the synthesized material to be examined without the interference of subsequent high-temperature consolidation processes, thus avoiding unwanted structural changes such as grain growth and second phase formations.
A Nomogram-Based Model to Predict Respiratory Dysfunction at 6 Months in Non-Critical COVID-19 Survivors
Authors: De Lorenzo Rebecca , Magnaghi Cristiano , Cinel Elena , Vitali Giordano , Martinenghi Sabina , Mazza Mario G. , Nocera Luigi , Cilla Marta , Damanti Sarah , Compagnone Nicola , Ferrante Marica , Conte Caterina , Benedetti Francesco , Ciceri Fabio , Rovere-Querini Patrizia 
Published: February 2022

ObjectiveTo assess the prevalence of respiratory sequelae of Coronavirus disease 2019 (COVID-19) survivors at 6 months after hospital discharge and develop a model to identify at-risk patients.Patients and MethodsIn this prospective cohort study, hospitalized, non-critical COVID-19 patients evaluated at 6-month follow-up between 26 August, 2020 and 16 December, 2020 were included. Primary outcome was respiratory dysfunction at 6 months, defined as at least one among tachypnea at rest, percent predicted 6-min walking distance at 6-min walking test (6MWT) ≤ 70%, pre-post 6MWT difference in Borg score ≥ 1 or a difference between pre- and post-6MWT oxygen saturation ≥ 5%. A nomogram-based multivariable logistic regression model was built to predict primary outcome. Validation relied on 2000-resample bootstrap. The model was compared to one based uniquely on degree of hypoxemia at admission.ResultsOverall, 316 patients were included, of whom 118 (37.3%) showed respiratory dysfunction at 6 months. The nomogram relied on sex, obesity, chronic obstructive pulmonary disease, degree of hypoxemia at admission, and non-invasive ventilation. It was 73.0% (95% confidence interval 67.3–78.4%) accurate in predicting primary outcome and exhibited minimal departure from ideal prediction. Compared to the model including only hypoxemia at admission, the nomogram showed higher accuracy (73.0 vs 59.1%, P &lt; 0.001) and greater net-benefit in decision curve analyses. When the model included also respiratory data at 1 month, it yielded better accuracy (78.2 vs. 73.2%) and more favorable net-benefit than the original model.ConclusionThe newly developed nomograms accurately identify patients at risk of persistent respiratory dysfunction and may help inform clinical priorities.
Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study
Authors: Landete Pedro , Fernández-García Carlos Ernesto , Aldave-Orzaiz Beatriz , Hernández-Olivo Marta , Acosta-Gutiérrez Carmen M. , Zamora-García Enrique , Ancochea Julio , González-Rodríguez Águeda , García-Monzón Carmelo 
Published: February 2022

IntroductionGiven that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and advanced liver fibrosis in patients with clinical and polygraphic criteria of OSA (n = 153) and in subjects with normal lung function parameters (NLP, n = 43).MethodsHepatosteatosis, NASH, and advanced liver fibrosis were determined by blood-based non-invasive tools, such as the fatty liver index and the hepatic steatosis index, a serum lipidomic (OWLiver™) test, and three distinct fibrosis algorithms, respectively. Logistic regression models adjusted by potential confounders were performed to evaluate risk factors.ResultsInsulin resistance and dyslipidemia were more frequent in patients with OSA than in subjects with NLP. The prevalence of hepatosteatosis was significantly higher in patients with OSA than in subjects with NLP. NASH was also found more frequently in patients with OSA than in subjects with NLP. In contrast, advanced liver fibrosis was rarely detected in the entire study population, and no significant differences were observed between patients with OSA and subjects with NLP. Besides male gender, increased body mass index (BMI), and presence of type 2 diabetes, percentage of sleep time with oxygen saturation &lt;90% (Tc90%) was the only polygraphic variable significantly associated with NASH in patients with OSA.ConclusionsThis study shows that hepatosteatosis and NASH are highly prevalent in patients with OSA and indicates that those with a Tc90% higher than 10% are at increased risk for NASH.
Erector Spinae Plane Block in Abdominal Surgery: A Meta-Analysis
Authors: Viderman Dmitriy , Aubakirova Mina , Abdildin Yerkin G. 
Published: February 2022

BackgroundAbdominal surgery is one of the most definitive and mainstay treatment options for abdominal pathologies in clinical practice. Acute postoperative pain is a major challenge in the postoperative period. Although opioids are commonly used for analgesia after major abdominal surgeries, they can lead to side effects, such as nausea and vomiting, constipation, pruritus, and life-threatening respiratory depression. Regional anesthetic techniques are commonly used to prevent or minimize these side effects. The objective of this meta-analysis is to assess the effectiveness of erector spinae plane block (ESPB) and standard medical (no block) pain management after major abdominal surgeries.MethodsWe searched for articles reporting the results of randomized controlled trials on ESPB and no block in pain control published before May 2021.ResultsThe systematic search initially yielded 56 publications, 49 articles were excluded, and seven randomized clinical trials were included and analyzed. We extracted the data on postoperative opioid consumption, the efficacy of pain relief, time to the first opioid demand, and the rate of postoperative complications in the ESPB group and no block group.ConclusionsOpioid requirement and time to first analgesic request were significantly reduced in the ultrasound-guided ESPB group, but pain scores, nausea, and vomiting did not differ significantly after pooling the results of the block and no block studies. There were no reports on serious complications related to ESPB.
Ropivacaine Inhibits Lung Cancer Cell Malignancy Through Downregulation of Cellular Signaling Including HIF-1α In Vitro
Authors: Shen Junmei , Han Lina , Xue Yongxian , Li Chao , Jia Huiqun , Zhu Kangsheng 
Published: February 2022

Background: Ropivacaine is widely used to induce regional anesthesia during lung cancer surgery. Previous studies reported that amide-linked local anesthetics, e.g., ropivacaine, affected the biological behavior of lung adenocarcinoma cells, but the conclusion is controversial and warrants further study. This study set out to investigate the biological effects of ropivacaine on cultured lung cancer cells and underlying mechanisms.Methods: Lung cancer cell lines (A549 and H1299) were cultured and then treated with or without ropivacaine (0.5, 1, and 2 mM) for 48 or 72 h. Their proliferation, migration, and invasion together with cell death and molecules including hypoxia inducible factor (HIF)-1α, VEGF, matrix metalloproteinase (MMP)-1, MMP-2, and MMP-9 expression associated with these changes were determined.Results: Ropivacaine significantly inhibited proliferation and migration, invasion, and cell death in a concentration-dependent manner in both cell lines. Ropivacaine also promoted cell death and induced a concentration- and time-dependent cell arrest towards the G0/G1 phase. Expression of VEGF, MMP-1, MMP-2, MMP-9, and HIF-1α in both cell lines was also inhibited by ropivacaine in a concentration-related manner.Conclusion: Our data indicated that ropivacaine inhibited lung cancer cell malignancy, which may be associated with downregulation of cell-survival-associated cellular molecules. The translational value of the current work is subjected to further study.
A Numerical and Experimental Investigation of a Confluent Jets Ventilation Supply Device in a Conference Room
Authors: Andersson Harald , Cehlin Mathias , Moshfegh Bahram 
Published: February 2022

In this study, confluent jets ventilation (CJV) supply devices with three different nozzle arrays (1 × 19, 2 × 19, 3 × 19) were investigated both numerically and experimentally at two different airflow and supply air temperature set-ups. The performance of the CJV supply devices was investigated concerning thermal comfort, indoor air quality (IAQ), and heat removal effectiveness in a conference room environment. A comparison between the experimental and numerical results showed that the ϑ2¯−f model had the best agreement out of the investigated turbulence models. The numerical results showed that the size of the array had a great impact both on near-field development and on the conditions in the occupied zone. A larger array with multiple rows and a lower momentum conserved the inlet temperature and the mean age of the air better than a single-row array with a higher momentum. A larger array with multiple rows had a higher IAQ and a greater heat removal effectiveness in the occupied zone because the larger array conserved the mean age of air better and the buoyancy driven flow was slightly better at removing the heat. Because of the lower inlet velocities, they also had lower velocities at ankle level, which decreased the risk of draft and thermal discomfort.
Remote Sensing of Ecosystem Water Use Efficiency in Different Ecozones of the North China Plain
Authors: Hu Yungang , Li Guangchao , Chen Wei 
Published: February 2022

Water use efficiency (WUE), as an environmental factor of metabolism in different ecosystem functional areas, is a key indicator of the ecosystem carbon-water cycle. WUE is defined as the ratio of carbon absorbed by ecosystems to water evaporated. Exploring the spatiotemporal variation in carbon and water cycles in different ecological zones of the North China Plain and their driving factors is important for the ecological management and sustainable development of the different ecological zones in the North China Plain. Based on remote sensing data products, this paper studies the spatiotemporal variations of WUE and their driving factors in different ecological functional areas of the North China Plain from 2001 to 2017. This study found that: (1) The spatial distribution of WUE and gross primary production (GPP) in the North China Plain is similar, with the multiyear average of WUE at 0.74 g C m−2 y−1. The variation trend of WUE is mainly affected by the variation trend of GPP (44.38% of the area of the North China Plain). (2) The change trend of WUE mainly showed a mild decrease and a mild increase, accounting for 73.22% of the area of the North China Plain; the area with medium-low fluctuation of WUE accounted for the largest proportion, accounting for 59.90% of the area of the North China Plain. In addition, the multiyear average values of WUE in the ecological functional area are Qin Ling Mountains deciduous forests > Central China loess plateau mixed forests > Mongolian-Manchurian grassland > Ordos Plateau steppe > Changjiang Plain evergreen forests > Huang He Plain mixed forests > Bohai Sea saline meadow, in the order from high to low. (3) The influence of precipitation on WUE was higher than that of temperature. The area of WUE that increased with the increase of precipitation accounted for 23.74% of the area of the North China Plain and was mainly distributed in the Qin Ling Mountains deciduous forests, Changjiang Plain evergreen forests, and Huang He Plain mixed forests’ ecological functional areas. The results of the study can provide a reference and theoretical basis for the conservation and management of carbon and water cycles in the functional areas of North China’s ecosystems.
Gerakan Perempuan Subaltern Ekofeminisme dalam Melawan Pembangunan PLTU 2 Indramayu
Authors: Cusdiawan Cusdiawan , Abdoellah Oekan S. , Manan Firman 
Published: February 2022

This research examines the struggle of women in rejecting development that is considered damaging to the environment. The problem asked in this study, namely "How is the process of the subaltern ecofeminism women's movement in Indramayu against the construction of PLTU 2 ?". Meanwhile, the purpose of the research is to describe the process of the subaltern ecofeminism women's movement in Indramayu against the construction of PLTU 2. This research was conducted using a qualitative method with a feminist perspective, and took place in Mekarsari Village, Patrol District, Indramayu Regency which became the site of PLTU 2 construction. subaltern groups, because of their position outside of social and political representation, this development will further marginalize them. Therefore, they took the fight in the form of social movements. In this movement, women affirm the spirit of ecofeminism. This article looks at the process of the movement with a social movement integration approach (political opportunity structure, mobilization structure and framing process), so that the factors of political economy structure, mobilization structure and framing are considered an important part of the process of emergence and development of a movement
Is It Easy to Supply a Cytogenetic Diagnosis? Examples of Two Clinical Cases with Mosaicism on the 18th Chromosome
Authors: Головатая Е.И. , Голубева С.В. , Мотюк И.Н. 
Published: February 2022

В статье представлены два наблюдения с хромосомными аномалиями: 1) частичная моносомия длинного плеча 18-й хромосомы размером 29 Mb в мозаичной форме;2) частичная моносомия длинного плеча 18-й хромосомы размером 14 Mb, представленная в двух клонах клеток (с делетированной и кольцевой хромосомами). Материалом для исследования были клетки периферической крови. Рассмотрены клинические данные, этапы постановки генетического диагноза, роль генетического консультанта в установлении генетической патологии, результаты исследований методами стандартного кариотипирования (GTG-banding) и хромосомного микроматричного анализа (SNP array). Делеция генетического материала выявлена с помощью хромосомного микроматричного анализа, окончательный кариотип установлен по совокупности результатов двух методов. Проанализирована возможность выявления структурной перестройки и мозаицизма разными методами исследования.
The article presents two observations with chromosomal aberrations: 1) mosaic partial monosomy of the long arm of the 18th chromosome, 29Mb in size; 2) partial monosomy of the long arm of chromosome 18, 14Mb in size, presented in two clones of cells (with deleted and ring chromosomes). The material for the study were peripheral blood cells. Clinical data, stages of a genetic diagnosis, the role of the genetic consultant in the identification of genetic pathology, research results by standard karyotyping (GTG- banding) and chromosomal microarray analysis (SNP array) are considered. Deletion of the genetic material was detected using chromosomal microarray analysis, the final karyotype was established by the combination of the results of the two methods. The possibility of revealing structural rearrangement and mosaicism by different research methods is analyzed.