bluuebunny/crossref_metadata_2025_split huggingface dataset:
Road Safety Analysis of Autonomous Vehicles
Authors: Szűcs Herman , Hézer Jozefin 
Published: June 2022

For the widespread use of Autonomous Vehicles (AVs), a huge number of challenges must be solved by vehicle manufacturers, in contrast they do have significant potential to increase road safety in both passenger and freight transport. In addition to reducing road traffic accidents and traffic jams, AVs also offer a major opportunity to reduce pollutant emissions and CO2 emissions from environmental point of view. In order to implement accident-free traffic, also called Vision Zero, it is essential to examine the safety and reliability of AVs. This article analyzes road traffic accident data and the potential safety benefits of AVs. Furthermore, the paper also sets the safety of the conventional vehicles against AVs and examines the type, location, causes, and dynamics of the accidents. The article also provides an overview over the current development trends and challenges, such as the risk of cyber-attacks, the necessary improvements in sensing technologies, and the not insignificant moral issue of AVs.
Протизапальні властивості стандартизованої рослинної композиції BNO 2103 у щурів з флогоген-індукованим набряком стопи
Authors: Черних В. В. , Шебеко С. К. , Зупанець К. О. 
Published: June 2022

Канефрон® Н – відомий препарат для лікування сечостатевих захворювань. Одним з його ключових ефектів є протизапальний, що було показано низкою досліджень. Патогенез хронічної хвороби нирок (ХХН) асоційований зі запаленням, тому пошук ефективних протизапальних засобів є актуальним. Оскільки досліджений спектр ефективності засобу базується тільки на частині нозологій з групи ХХН, вважали за доцільне вивчити нюанси механізмів протизапальної дії стандартизованої рослинної композиції BNO 2103, що є активним інґредієнтом Канефрону® Н. Позитивні результати можуть бути обґрунтуванням розширення спектра застосування BNO 2103.
Мета дослідження – вивчити протизапальні властивості стандартизованої рослинної композиції BNO 2103 на моделях набряку стопи в щурів, викликаного різними флогогенами (карагенін, простагландин Е2). Експериментальне дослідження проводилось на 60 самцях білих безпородних щурів вагою 150–200 г, які були розподілені на 2 серії по 30 тварин, кожна серія включала 3 групи. Запалення моделювали за допомогою субплантарного введення флогогенів – карагеніну та простагландину Е2. Досліджувану композицію та препарат порівняння – диклофенак натрію – вводили внутрішньошлунково одноразово. Спостереження, фіксування об’єму набряку та оцінювання протизапальної активності відбувались за 0,5; 1; 2 і 3 год після введення карагеніну через 0,5; 1 і 2 год після введення простагландину Е2. Композиція BNO 2103 проявила виражену антиексудативну дію на моделі карагенінового набряку, за якою поступалася препарату порівняння диклофенаку натрію, який є неселективним інгібітором циклооксигенази. На моделі простагландинового набряку композиція BNO 2103 проявила антиексудативну дію не гірше, ніж компаратор. Композиція виявила здатність інгібувати циклооксигеназний шлях перетворення арахідонової кислоти та утворення медіаторів запалення, продемонструвала значний антипростагландиновий ефект.Таким чином, стандартизована рослинна композиція BNO 2103 має значний протизапальний ефект, здійснює інгібуючий вплив на ексудативне запалення, викликане різними флогогенами (карагенін, простагландин Е2), пригнічуючи циклооксигеназний шлях перетворення арахідонової кислоти, що, найімовірніше, зумовлено наявністю в складі засобу флавоноїдів, ефірних олій і фенольних сполук. Це дозволяє розглядати BNO 2103 як перспективний антифлогістик для лікування запальної патології нирок.
Results Of Excision Of Dorsal Spinal Meningioma With Severe Neuro Deficits
Authors: Awwal MA , Sakeb Najmus , Forhad Sheikh , Siddiqui Irfanul Huq , Alam Md Shamsul 
Published: June 2022

Although being a slow growing tumor, spinal meningiomas are often diagnosed late and presents with features of significant cord compression that essentially warrants surgical management. To assess the clinical and functional outcome of excision of dorsal spinal meningioma. Within the period of July 2003 to June 2012, retrospective review of the records of 23 patients (Male:07, Female:26, age range, 34-68 years) with postoperative histological confirmation of meningioma were evaluated. Pre- and postoperative neurological state was classified according to the Frankel scale and functional outcome was assessed according to Levy Score. Chi-squared test and z-test was used for statistical analysis using SPSS. The mean age was 48.30=03.50 years with significant female predominance. The posterior and posterolateral position was significant causing significant neuro-deficit. Satisfactory surgical results were achieved in 78.90% cases (Levy Score) and 82.82% cases (Frankel grading). Surgical resection of spinal meningiomas is a safe and effective procedure even with severe neurological deficits.
JCMCTA 2013 ; 24 (2): 14-18
Morquio Disease : A Case Report
Authors: Chowdhury Pranab Kumar , Chowdhury Dhiman , Karim Mohammed Rezaul , Gosh Sankar Kumar 
Published: June 2022

Mucopolysaccharidoses (MPS) are hereditary progressive metabolic disorder caused by the absence or malfunctioning of lysosomal enzyme needed to breakdown molecule called glycosaminoglycan (GAGS) [1]. The major GAGS are chondrotin 4 sulfate, heparin sulfate, dermaten sulfate and hyaluranan. People with mucopolysacaride disease either do not produce enough one of the enzyme required to break down these sugar chain into simple molecule or they produce enzyme that don't work [2]. Morquio disease (MPS IV) is caused by a deficiency of Nacetylgalactosamine-6-sulfatase (MPS IV-A) or of B-galactosidase (MPS IV-B). Both result in the defective degradation of keratan sulfate [2,3]. The incidence of MPS is between 3.5 to 4.5/100000. The most common subtype is MPS III. Our case is a 8 month old son of a non-consanguineous parents from Sandwip, Chittagong, admitted to the Department of Paediatrics, Chittagong Medical College Hospital with a history of gibbus at thoracolumber region for last two months. But on examination he was found to be macrochphalic, stunted and wasted. Skeletal survey had shown some consistent findings of Morquio disease and his urine for Mucopolysaccharidoses screening test is also positive. We have reported this case of MPS as it is rarer and among the MPS, Morquio disease is also not a commoner one [4,5). It is also necessary for early differentiation of MPS IV from some treatable clinical entity like congenital hypothroidism.
JCMCTA 2013 ; 24 (2): 48-50
MODERN VERSIONS OF SHEVCHENKO’S ALLEGED PATERNITY
Authors: Boron Oleksandr 
Published: June 2022

The creation of a new scholarly biography of Shevchenko is impossible without testing plausible assumptions and hypotheses prevalent in the mass consciousness. Most of them do not stand up to criticism and miss any detailed analysis, while others seem at first glance so convincing that they are perceived almost as a truth. Shevchenko‘s alleged paternity used to be one of the taboo issues but now it is fervently debated, attracting many — both admirers of his word and ill-wishers.
In the media, popular editions, and even outlines of the lessons available on the Internet, the idea that the poet was the father of Hanna Zakrevska’s (1822—1857) daughter, Sofiia Platonivna, married Felen (1845—?), is being replicated. Volodymyr Syrotenko (Verbytskyi),
Candidate of Technical Sciences, actively defends this view. Another hypothesis belongs to the writer Antonina Tsvyd who tries, in her research paper, to substantiate legendary folk stories about the alleged Shevchenko’s son Fedir whose mother was an unknown resident of Sedniv.
The statements and assumptions made in the publications of these authors have been critically verified by comparison with dependable information, which showed that both versions do not have any real basis and contradict properly proven facts and documents. V. Syrotenko presents his conjectures as the purest truth, while A. Tsvyd, trying to find evidence for dubious legends, resorts to assumptions devoid of logic and common sense while leaving well-known circumstances without attention. Memoirs are also misinterpreted, in particular the ones of Oleksandr Chuzhbynskyi, and it once again testifies to the urgent need for a critical edition of a corpus of memoirs about Shevchenko. It is especially unfortunate that V. Syrotenko’s inventions are recklessly picked up by the community of teachers who ‘legalize’ them in publications and the educational process.
Análsis de los tratamiento farmacológicos y no farmacológicos en el síndrome de hipermovilidad articular (SHA) durante el periodo 2017 al 2021: Una revisión sistemática
Authors: Takahashi-Ferrer Carolina Mayo , Parreño-Tipian Juan Manuel 
Published: June 2022

Objetivos: Analizar los tratamientos no farmacológicos y farmacológicos en pacientes con síndrome de hipermovilidad articular (SHA). Métodos: Es una revisión sistemática de trabajos de investigación, donde se siguió la recomendación PRISMA buscando artículos científicos publicada en: Redalyc, Eric, Sciencedirect, Latindex, Scopus, Alicia, Elsevier, Pubmed, LILACS, SciELO, EBSCO y Google Scholar, durante el periodo 2017 al 2021. Resultados: Del total inicial de 261019 estudios correspondientes a la búsqueda, sin aplicar filtros, se seleccionaron cuatro artículos de los cuales todas describen tratamientos no farmacológicos considerando la terapia física como la alternativa más adecuada y eficaz para fortalecer y reeducar las articulaciones, para así reducir el dolor de forma temporal. No se debe sobre esforzar y se debe respetar las limitaciones de cada paciente; de lo contrario, sería perjudicial para la salud. Por otro lado, un solo estudio de los mencionados, detalla tratamientos farmacológicos recomendando a la amitriptilina y a la fluoxetina como la opción para mitigar el dolor crónico, en presencia de crisis de dolor se recomienda el paracetamol, sin embargo se recalca que el uso de los antiinflamatorios no esteroideos (AINE) y los opiáceos ya que también podrían usarse para dolor agudo, mas no se recomiendan por no ser bien tolerados por estos pacientes debido a la fragilidad de sus tejidos por la alteración a nivel de colágeno que presentan. Conclusiones: No hay avances significativos en los últimos cinco años con respecto a tratamientos para pacientes con SHA en comparación con años pasados. Existe una mayor evidencia sobre terapia física para tratar las dolencias y sintomatología de estos pacientes en comparación a las opciones de fármacos que se puede recurrir para mitigar el dolor y reducir la sintomatología.
Effects of Knee Joint Angle and Contraction Intensity on the Triceps Surae Stiffness
Authors: Lin Ming , Deng Weixin , Liang Hongying , Yu Suiqing , Xu Qin , Liu Chunlong 
Published: June 2022

Purpose: Monitoring the contractility of muscles assists the clinician in understanding how muscle functions as part of the kinetic system. This study investigated the effect of knee joint angles under different resistance on the stiffness of the medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) muscles using the shear wave elastography (SWE) technique.Methods: A total of 22 females were recruited. During isometric plantar flexion, at knee 0-degree (fully extended) and knee 90-degree (flexed 90°), the shear modulus on the MG, LG, and SOL was measured by shear wave elastography at no contraction and two intensities (40% and 80%) of maximal voluntary contraction (MVC). Shear modulus is a mechanical parameter to describe stiffness, and stiffness is a proxy for muscle contractility.Results: There were moderate-to high-positive correlations between the active stiffness of triceps surae muscles and isometric contraction intensity (r: 0.57–0.91, p＜0.001). The active stiffness in MG and LG with extended knees was higher than that with flexed knees (p＜0.001). The active stiffness in SOL with flexed knee was higher than that with extended knee (p＜0.001).Conclusion: Active stiffness can be considered a quantitative indicator generated by the force output of the triceps surae. Different knee joint angles cause three triceps surae muscles to exhibit non-uniform mechanical properties, which may explain part of the mechanism of soft tissue injury during physical exercise.
Observations of Wave Height Amplification Behind an Oyster Castle Breakwater System in a High-Energy Environment: Gandys Beach, NJ
Authors: Bredes Amy L. , Miller Jon K. , Kerr Laura , Brown Dana Rose 
Published: June 2022

This study reports findings of an analysis of modifications to the incident wave field caused by constructed Oyster Castle® breakwater systems at Gandys Beach Preserve in Downe Township, NJ. The Nature Conservancy’s (TNC) Gandys Beach Preserve is a one-mile stretch of beach located along with intertidal mud flats, sandy beaches, tidal creeks, and salt marshes. Gandys Beach can be classified as a high-energy environment, with open water fetches exceeding 30 miles, and a tidal range on the order of 2 m. The Gandys Beach living shoreline project was designed and constructed by TNC in partnership with the United States Fish and Wildlife Service (USFWS) to investigate the effectiveness of various natural and nature-based features (NNBFs) in protecting and enhancing salt marshes and beaches in high (er) energy environments. Many of the NNBF techniques used at Gandys Beach, such as Oyster Castle® block breakwaters (Oyster Castles), had only been implemented at smaller scales in New Jersey prior to the project. Stevens was contracted by USFWS/TNC to evaluate the impact of the breakwater systems on incident waves. Four breakwater sections along the beach were selected to monitor wave attenuation. Month-long deployments of wave staffs and pressure sensors occurred in the summer and winter of 2019. Analysis of the data indicates that when crests of the Oyster Castles are exposed the breakwater system effectively attenuates waves. However, when the structures are submerged, wave height attenuation decreases, and under certain conditions wave heights behind Oyster Castles can be amplified more than 80%. These results are troubling, especially in areas experiencing sea level rise where the frequency of submergence will likely increase in the future. Due to the complex nature of Gandys Beach, exact mechanisms causing this amplification remain uncertain. Furthermore, transmission coefficients (Kt) above 1 are not typically modeled in existing empirical equations. Seabrook and Hall (Coast. Eng. Proc., 1998, 1 (26), 2000) is the only studied empirical formula that indicated an amplification of the Hs as observed during these field deployments and therefore was used to model Kt. However, poor agreement between the modeled and observed Kt was found and a better predictive tool is needed.
Fluorescence Detection of Cancer Stem Cell Markers Using a Sensitive Nano-Aptamer Sensor
Authors: Ding Jie , Xu Weiqiang , Tan Jing , Liu Zhifang , Huang Guoliang , Wang Shoushan , He Zhiwei 
Published: June 2022

Antigen CD133 is a glycoprotein present on the surface of cancer stem cells (CSCs), which is a key molecule to regulate the fate of stem cells and a functional marker of stem cells. Herein, a novel fluorescence “turn-on” nano-aptamer sensor for quantifying CD133 was designed using hybridization between CD133-targeted aptamers and partially complementary paired RNA (ssRNA), which were modified on the surface of quantum dots (QDs) and gold nanoparticles (AuNPs), respectively. Owing to the hybridization of aptamers and ssRNA, the distance between QDs and AuNPs was shortened, which caused fluorescence resonance energy transfer (FRET) between them, and the florescence of QDs was quenched by AuNPs. When CD133 competitively replaced ssRNA and was bound to aptamers, AuNPs-ssRNA could be released, which led to a recovery of fluorescent signals of QDs. The increase in the relative value of fluorescence intensity was investigated to linearly correlate with the CD133 concentration in the range of 0–1.539 μM, and the detection limit was 6.99 nM. In confocal images of A549 cells, the CD133 aptamer sensor was further proved applicable in lung cancer cell samples with specificity, precision, and accuracy. Compared with complicated methods, this study provided a fresh approach to develop a highly sensitive and selective detection sensor for CSC markers.
Validation of T-MoCA in the Screening of Mild Cognitive Impairment in Chinese Patients With Atrial Fibrillation
Authors: Lai Yiwei , Zhao Manlin , Jiang Chao , Du Xin , Wang Zhiyan , Zhang Jingrui , Bai Yu , Xu Baolei , Zhang Weiwei , Tang Ribo , Sang Caihua , Long Deyong , Dong Jianzeng , Ma Changsheng 
Published: June 2022

BackgroundAtrial fibrillation (AF) is associated with a high risk of mild cognitive impairment (MCI) and dementia. However, feasible and simple instruments that facilitate the regular assessment of cognitive status in patients with AF remain underdeveloped.MethodsCognitive function was first evaluated using telephone Montreal cognitive assessment (T-MoCA), and then patients were invited for an in-person interview for cognitive assessment using both Clinical Dementia Rating (CDR) and mini-mental status evaluation (MMSE). Using CDR = 0.5 as a reference standard, the ability of T-MoCA and MMSE to discriminate cognitive dysfunction, stratified by education level, was tested by receiver–operating curve (ROC) analysis. The net reclassification index was calculated for comparison between the performance of T-MoCA and MMSE.ResultsOne hundred and one patients completed both telephone and in-person interview. Thirty-five MCI patients were identified as MCI using the criteria of CDR = 0.5. The areas under the ROC curve of T-MoCA were 0.80 (0.71–0.89), 0.83 (0.71–0.95), and 0.85 (0.64–0.92) for all patients, patients with high educational level, and patients with low education level, respectively. The optimal threshold was achieved at 16/17 with a sensitivity of 85.7% and a specificity of 69.7% in overall patients, 15/16 with a sensitivity of 88.2% and a specificity of 64.5% in the low educational level patients, and 16/17 with a sensitivity of 77.8% and a specificity of 87.9% in the high educational level patients. Compared to the criterion MMSE ≤ 27 and MMSE norms for the elderly Chinese community, the stratified T-MoCA threshold improves correct classification by 23.7% (p = 0.033) and 30.3% (p = 0.020), respectively.ConclusionT-MoCA is a feasible and effective instrument for MCI screening in patients with AF.
Incidence and Predictors of Cardiac Arrhythmias in Patients With COVID-19
Authors: Mouram Sahar , Pannone Luigi , Gauthey Anaïs , Sorgente Antonio , Vergara Pasquale , Bisignani Antonio , Monaco Cinzia , Mojica Joerelle , Al Housari Maysam , Miraglia Vincenzo , Del Monte Alvise , Paparella Gaetano , Ramak Robbert , Overeinder Ingrid , Bala Gezim , Almorad Alexandre , Ströker Erwin , Sieira Juan , Brugada Pedro , La Meir Mark , Chierchia Gian Battista , de Asmundis Carlo 
Published: June 2022

BackgroundCoronavirus disease 2019 (COVID-19) is a systemic disease caused by severe acute respiratory syndrome coronavirus 2. Arrhythmias are frequently associated with COVID-19 and could be the result of inflammation or hypoxia. This study aimed to define the incidence of arrhythmias in patients with COVID-19 and to correlate arrhythmias with pulmonary damage assessed by computed tomography (CT).MethodsAll consecutive patients with a COVID-19 diagnosis hospitalized at Universitair Ziekenhuis Brussel, Belgium, between March 2020 and May 2020, were screened. All included patients underwent a thorax CT scan and a CT severity score, a semiquantitative scoring system of pulmonary damage, was calculated. The primary endpoint was the arrhythmia occurrence during follow-up.ResultsIn this study, 100 patients were prospectively included. At a mean follow-up of 19.6 months, 25 patients with COVID-19 (25%) experienced 26 arrhythmic episodes, including atrial fibrillation in 17 patients, inappropriate sinus tachycardia in 7 patients, atrial flutter in 1 patient, and third-degree atrioventricular block in 1 patient. No ventricular arrhythmias were documented. Patients with COVID-19 with arrhythmias showed more often need for oxygen, higher oxygen maximum flow, longer QTc at admission, and worse damage at CT severity score. In univariate logistic regression analysis, significant predictors of the primary endpoint were: the need for oxygen therapy (odds ratio [OR] 4.59, 95% CI 1.44–14.67, p = 0.01) and CT severity score of pulmonary damage (OR per 1 point increase 1.25, 95% CI 1.11–1.4, p &lt; 0.001).ConclusionsIn a consecutive cohort of patients with COVID-19 the incidence of cardiac arrhythmias was 25%. The need for oxygen therapy and CT severity score were predictors of arrhythmia occurrence during follow-up.
Depositional Controls on Detrital Zircon Provenance: An Example From Upper Cretaceous Strata, Southern Patagonia
Authors: Dobbs Stephen C. , Malkowski Matthew A. , Schwartz Theresa M. , Sickmann Zachary T. , Graham Stephan A. 
Published: June 2022

Understanding how depositional environments within a sedimentary system redistribute and sequester sediment is critical for interpreting basin-scale provenance trends. However, sedimentary source-to-sink models commonly examine temporal changes and do not consider how variation in sedimentation processes across a dispersal pathway may result in contrasting provenance signatures. In this paper, we demonstrate a down-paleoslope shift in detrital zircon provenance signatures correlated with shallow-marine lithofacies patterns from the Upper Cretaceous La Anita Formation and underlying continental slope lithofacies of the Alta Vista Formation (Magallanes-Austral Basin, southern Patagonia). New stratigraphic, sedimentologic, and lithofacies analysis results from the La Anita Formation suggest an upward shoaling succession, from a 1) storm-influenced shoreface, 2) fluvially dominated, wave-influenced delta, and a 3) high-energy, gravelly foreshore. Stratigraphic sections are paired with U-Pb detrital zircon sandstone samples (N = 20; n = 5,219), which provide both maximum depositional ages and provenance characteristics. While all samples contain abundant zircon derived from the Andean volcanic arc (ca. 145–75 Ma), the amount from both Jurassic distal volcanic massifs (ca. 188–162 Ma) and recycled orogenic sources exhumed during the advance of the Cretaceous fold-and-thrust belt (&gt;200 Ma; 157–142 Ma) vary with changes in depositional environment. We argue that down-paleoslope, systematic enriching of local fold-and-thrust belt material within the La Anita Formation is reflective of progressive mixing of grains transported via shallow-marine processes, while distally enriched fluvio-deltaic transported zircons were sourced from large, regional catchments. This suggests that competition between transport processes across a shallow and marginal marine sequence of rocks affects the resulting provenance signatures recorded within a single stratigraphic succession. These data also detail the degree of sediment pathway connectivity between shallow-marine sources and deep-marine sinks. Detrital zircon results from muddy continental slope facies of the Alta Vista Formation are made up entirely locally derived material, while zircon results from deep-water, sand-rich channel facies of the Formation are indistinguishable from coeval fluvio-deltaic zircon signatures. This implies that continental shelf-to-slope connectivity in a sediment dispersal system, via submarine canyons or shelf-edge delta progradation, is necessary for detrital zircon distributions from the shallow-marine realm to propagate into the deeper marine.