bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epithelial necrotic cells provoke exacerbated inflammatory response in gingival fibroblasts
Authors: Sordi Mariane Beatriz , Panahipour Layla , Gruber Reinhard 
Published: October 2022

Abstract
Objectives: to study how cellular lysates could affect the expression of inflammatory cytokines of periodontal-related cells.
Materials and Methods: cell suspensions were submitted to different treatments: lysate 1 – no treatment; lysate 2 – sonication; and lysate 3 – freeze/thawing. All lysates were centrifuged, and the supernatants were used for experimentation. Cell viability assays, RT-qPCR of IL1, IL6 and IL8, IL6 immunoassay, and immunofluorescence of NF-kB were applied to verify the inflammatory crosstalk potential of damaged cells over healthy plated cells. Further, titanium discs and collagen membranes were treated with the cell lysates and checked for IL8 RT-qPCR expression.
Results: lysates obtained upon sonication or freeze/thawing of oral squamous cell carcinoma cell lines provoked a robust increase in the expression of IL1, IL6, and IL8 by gingival fibroblasts, which was confirmed by immunoassays for IL6. Lysates obtained from the gingival fibroblasts failed to increase the expression of inflammatory cytokines in oral squamous cell carcinoma cells. Epithelial cell lysates caused the activation of the NF-kB signalling cascade in gingival fibroblasts as indicated by the phosphorylation and nuclear translocation of p65, indicating inflammation. Finally, epithelial lysates could adhere to the titanium and collagen membrane surfaces and increase IL8 expression by gingival fibroblasts.
Conclusions: injured oral epithelial cells can release factors that incite gingival fibroblasts to become pro-inflammatory.
Clinical Relevance: injuries affecting the oral mucosa generate epithelial fragments that may reach the underlying connective tissue and provoke inflammation. These injuries are routinely caused by mastication, sonication for teeth cleaning, prostheses maladaptation, implant drilling, and teeth preparation.
Should we change the treatment plan in early hepatocellular carcinoma with chronic kidney disease?
Authors: Soong Rueyshyang , Chao Wu-Po , Chai Shion-Wei , Chiang Po-Hsing , Chou Ta-Chun , Chen Yi-Chan 
Published: October 2022

Abstract
Background
Chronic kidney disease (CKD) has been considered to be a poor prognostic factor for hepatocellular carcinoma (HCC). However, few studies have focused on early HCC and the impact of CKD on survival, which should be considered in curative treatment for early HCC.
Materials and Methods
Patients with BCLC stage 0/A were enrolled from 2009 to 2019. A total of 383 patients were divided into CKD stages 1, 2 and CKD stages 3, 4, and 5, based on estimated glomerular filtration rate. Overall survival (OS) and disease-free survival (DFS) of different treatments were determined using the Kaplan–Meier method.
Results
The CKD1,2 group had a significantly better OS than the CKD3,4,5 group (72.6 months vs 56.7 months; p = 0.003). DFS was similar between the groups (62.2 months vs 63.8 months, p = 0.717). In the CKD1,2 group, the surgically treated (OP) group had significantly superior OS (65.0 months vs 80.0 months, p = 0.014) and DFS (50.9 months vs 70.2 months, p = 0.020) than the radiofrequency ablation-treated group. In the CKD3,4,5 group, the OP group showed a survival advantage in OS (70.6 months vs 49.2 months, p = 0.004), while DFS was similar between treatment groups (56.0 months vs 62.2 months, p = 0.097).
Conclusion
CKD should not be considered to be a poor prognostic factor in early HCC patients. However, liver resection provides a survival advantage in CKD patients with early HCC.
Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice
Authors: Yu Yongquan , Wang Yucheng , Dong Yu , Shu Shuge , Zhang Di , Xu Jiayi , Zhang Ying , Shi Wei , Wang Shou-Lin 
Published: October 2022

Abstract
Phthalates are a group of neurotoxicants with cognitive-disrupting potentials. Given the structural diversity of phthalates, the corresponding neurotoxicity is dramatically altered. To identify the potential contributions of different phthalates on the process of cognitive impairment, data of 836 elders from the NHANES 2011–2014 cycles were used. Survey-weighted logistic regression and principal component analysis-weighted quantile sum regression (PCA-WQSR) models were applied to estimate the independent and combined associations of 11 urinary phthalate metabolites with cognitive deficit [assessed by 4 tests: Immediate Recall (IR), Delayed Recall (DR), Animal Fluency (AF), and Digit Symbol Substitution test (DSST] and to identify the potential phthalate with high weight. Laboratory mice were further used to examine the effect of phthalates on cognitive function and to explore the potential mechanisms. In logistic regression models, MBzP was the only metabolite positively correlated with four tests, with ORs of 2.53 [quartile 3 (Q3)], 2.26 (Q3), 2.89 (Q4) and 2.45 (Q2), 2.82 (Q4) for IR, DR, AF and DSST respectively. In PCA-WQSR co-exposure models, low-molecular-weight (LMW) phthalates were the only PC positively linked to DSST deficit (OR: 1.93), which was further validated in WQSR analysis (WQS OR7 − phthalates: 1.56 and WQS OR8 − phthalates: 1.55); consistent with the results of logistic regression, MBzP was the dominant phthalate. In mice, butyl benzyl phthalate (BBP), the parent phthalate of MBzP, dose-dependently reduced cognitive function and disrupted hippocampal neurons. Additionally, the hippocampal transcriptome analysis identified 431 differential expression genes, among which most were involved in inhibiting the neuroactive ligand‒receptor interaction pathway and activating the cytokine‒cytokine receptor interaction pathway. Our study indicates the critical role of BBP in the association of phthalates and cognitive deficits among elderly individuals, which might be speculated that BBP could disrupt hippocampal neurons, activate neuroinflammation and inhibit neuroactive receptors. Our findings provide new insight into the cognitive-disrupting potential of BBP.
Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: A single-center, randomized, controlled trial
Authors: Sekiguchi Ryo , Kinoshita Michiko , Kawanishi Ryosuke , Kakuta Nami , Sakai Yoko , Tanaka Katsuya 
Published: October 2022

Abstract
Background
Remimazolam confers a lower risk of hypotension than propofol. However, no studies have compared efficacy of remimazolam and propofol administered using target-controlled infusion (TCI). This study aimed to investigate hemodynamic effects of remimazolam and target-controlled propofol in middle-aged and elderly patients during the induction of anesthesia.
Methods
Forty adults aged 45–80 years with the American Society of Anesthesiologists Physical Status 1–2 were randomly assigned to remimazolam or propofol group (n = 20 each). Patients received either remimazolam (12 mg/kg/h) or propofol (3 µg/mL, TCI), along with remifentanil for inducing anesthesia. We recorded the blood pressure, heart rate (HR), and estimated continuous cardiac output (esCCO) using the pulse wave transit time. The primary outcome was the maximum change in mean arterial pressure (MAP) after induction. Secondary outcomes included changes in HR, cardiac output (CO), and stroke volume (SV).
Results
MAP tended to decrease after induction of anesthesia in both the groups, without significant differences between the groups (-41.1 [16.4] mmHg and − 42.8 [10.8] mmHg in remimazolam and propofol groups, respectively; mean difference: 1.7 [95% confidence interval: -8.2 to 4.9]; p = 0.613). Furthermore, HR, CO, and SV decreased after induction in both groups, without significant differences between the groups. Remimazolam group had significantly shorter time until loss of consciousness than propofol group (1.7 [0.7] min and 3.5 [1.7] min, respectively; p < 0.001). However, MAP, HR, CO, and SV were not significantly different between the groups despite adjusting time until loss of consciousness as a covariate. Remimazolam group tended to have a lower frequency of hypotension (MAP < 65 mmHg) than propofol group (7 [35%] and 11 [55%] cases, respectively; p = 0.341).
Conclusions
Hemodynamics were not significantly different between remimazolam and target-controlled propofol groups during induction of anesthesia. Thus, the choice, dose, and usage of anesthetics are important for hemodynamic stability while inducing anesthesia. Clinicians should monitor hypotension while inducing anesthesia with remimazolam as well as propofol.
Trial registration:
UMIN-CTR (UMIN000045612).
Unraveling the complex causality behind the Fe-N-C degradation in fuel cell
Authors: Bae Geunsu , Jin Song , Han Man Ho , Oh Hyung-Suk , Sougrati Moulay Tahar , Lee Kug-Seung , Seo Min Ho , Jaouen Frédéric , Choi Chang Hyuck 
Published: October 2022

Abstract
Beyond great advances in initial activity, Fe-N-C catalysts face the next challenge of stability issue in acidic medium that must be overcome to replace Pt in fuel cell cathode. However, the complex phenomena in fuel cells and consequential difficulty in understanding deactivation mechanisms of Fe-N-C cathodes impede solutions for prolonged stability. Here, we show time-resolved changes in active site density (SD) and turnover frequency (TOF) of Fe-N-C along with concurrent decrease in oxygen reduction reaction (ORR) current in temperature/gas controllable gas-diffusion electrode (GDE) flow cell. In operando diagnosis of Fe leaching identifies a strong dependence of SD changes on operating parameters, and draws a lifetime-dependent stability diagram that reveals a shift in prime degradation mechanism during the operations. A proof-of-concept strategy with site-isolated Pt ions as a non-catalytic stabilizer, supported by theoretical calculation, demonstrates enhanced fuel cell stability with reduced Fe dissolution, offering new design principle for durable Fe-N-C catalysts.
Czech News Dataset for Semantic Textual Similarity
Authors: Sido Jakub , Seják Michal , Pražák Ondřej , Konopík Miloslav , Moravec Václav 
Published: October 2022

Abstract

This paper describes a novel dataset consisting of sentences with two different semantic similarity annotations; with and without surrounding context. The data originate from the journalistic domain in the Czech language. The final dataset contains 138,556 human annotations divided into train and test sets. In total, 485 journalism students participated in the creation process. To increase the reliability of the test set, we compute the final annotations as an average of 9 individual annotation scores. We evaluate the dataset quality by measuring inter and intra-annotator agreements. Besides agreement numbers, we provide detailed statistics of the collected dataset. We conclude our paper with a baseline experiment of building a system for predicting the semantic similarity of sentences. Due to the massive number of training annotations (116,956), the model significantly outperforms an average annotator (0.92 versus 0.86 of Pearson's correlation coefficient).
Quantitative Analysis of the Right Ventricle in Non-Gated Myocardial Perfusion SPECT Imaging
Authors: Shahamiri Negar , Yazdi Mehran , Entezarmahdi Seyed Mohammad , Faghihi Reza , Geramifar Parham , Haghighatafshar Mahdi 
Published: October 2022

Abstract
Background. Recent studies have shown that the right ventricular (RV) analysis in myocardial perfusion imaging (MPI) SPECT can reveal some critical issues of heart disease. This study proposes a new algorithm for right ventricular 3D segmentation and quantification.
Methods. The proposed Quantitative Cardiac analysis in Nuclear Medicine imaging (QCard-NM) algorithm provides the RV myocardial surface estimation and create its contour using an iterative 3D model fitting method. The founded contour is then used for the RV quantitative analysis. The proposed method was assessed using various patient datasets and digital phantoms. First, the physician’s handmade contours were compared to the QCard-NM results using the Dice Similarity Coefficient (DSC). Second, the QCard-NM's repeatability was evaluated using repeated MPI scans in a single day. Third, the ability of QCard-NM analysis to classify the RCA stenosis was assessed. Fourth, the bias of Calculated RV cavity volume with the algorithms mentioned above was analyzed using 31 digital phantoms.
Results. The average DSC value was 𝟎𝟎. 𝟖𝟖𝟖𝟖 ± 𝟎𝟎. 𝟎𝟎𝟎𝟎 in the first dataset. In the second dataset, results imply that the Pearson correlation coefficient of the RV calculated cavity volume among two repeated scans was 0.87. The RV quantitative analysis using QCard-NM revealed an accuracy of 71.4% [p-value<0.05] detecting the RCA stenosis. In the phantom study, the mean absolute errors for calculated cavity volume were 22% and 38% for the QCard-NM and QPS, respectively.
Conclusion. We believe this preliminary study could lead to the development of a framework for improving the diagnosis of RCA abnormalities using RV quantitative analysis.
The impact of national sociodemographic variables on access to cardiac medicine and surgery in Haiti: Evidence from Haiti Cardiac Alliance
Authors: Bansal Esha , Patel Krishna , Lacossade Samantha , Gue Bennisoit , Acceme Kessy , Robinson Owen , Kwan Gene F , Wilentz James R 
Published: October 2022

Abstract
Background
In Haiti, cardiovascular disease is a leading cause of morbidity and mortality, with congenital and rheumatic heart disease comprising a large portion of disease burden. However, domestic disparities in cardiac care access and their impact on clinical outcomes remain poorly understood. We analyzed population-level sociodemographic variables to predict cardiac care outcomes across the ten Haitian administrative departments.
Methods
This cross-sectional study combines data from a 2016-17 Haitian national health survey with aggregate outcomes from the Haiti Cardiac Alliance (HCA) database (n = 1817 de-identified patients). By univariate and multivariate regression, the proportion of HCA patients belonging to three clinical categories (active treatment, lost to follow-up, deceased preoperatively) was modeled in relation to six population-level survey variables selected a priori.
Results
In univariate analysis, higher departmental rates of childhood growth retardation were associated with a lower proportion of patients in active care (OR = 0.979 [0.969,0.989], p = 0.002) and a higher proportion of patients lost to follow-up (OR = 1.016 [1.006,1.026], p = 0.009). In multivariate analysis, the proportion of department patients in active care was inversely associated with qualified prenatal care (OR = 0.980 [0.971,0.989], p = 0.005), child growth retardation (OR = 0.977 [0.972,0.983]), p = 0.00019), and travel time to nearest healthcare facility in an emergency (OR = 0.997 [0.993,1.001], p = 0.16); it was directly associated with adult employment (OR = 1.006 [0.996,1.015], p = 0.28). Similar multivariate results were obtained for departmental rates of loss to follow-up and preoperative mortality.
Conclusions
Population data on multiple sociodemographic variables meaningfully predicted domestic disparities in HCA clinical outcomes by region. These findings may help to identify underserved areas in Haiti, for whom targeted resources may increase continuity of care and success of cardiac care interventions. This approach may also be generalizable to other forms of specialty care in Haiti and other low-income countries.
Knowledge and Practice of Nurses towards Non-Pharmacological Pain Management Methods and Associated Factors at West Arsi Zone Public Hospitals, Oromia, Ethiopia, 2021: A Cross-Sectional Institution Based Study
Authors: Abdella Jabir , Oltaye Zewdie , Fetene Diriba 
Published: October 2022

Abstract

Background
Non-pharmacological pain management methods have a vital role in the management of pain and helps to minimize risks related to drugs. This study is intended to assess knowledge and practice level of nurses towards non-pharmacological pain management methods and associated factors at west Arsi zone public hospitals, Oromia, Ethiopia, 2021.
Method
Institutional-based cross-sectional study design was conducted on 418 nurses at west Arsi zone public hospitals from April 15 to April 30, 2021. The study subjects were selected by simple random sampling technique. Data was collected using a pre-tested self-administered questionnaire. Bivariate and multivariate analyses were carried out to identify associations. Odds ratios were calculated for related factors with a 95% confidence interval and Significant factor reported at P < 0.05 (CI).
Result
A total of 418 were included in the study with a response rate of 99.1%.This study shows that 66.7% of respondents had good knowledge and 53.8% of nurses had good practice about non-pharmacological pain management. Being having MSc educational status (AOR = 5.926(1.064–32.988)) and work experience of ≥ 11 years (AOR = 9.232(1.543–55.237) were significantly associated with knowledge. The study also shows that 30–39 age group (AOR = 2.276(1.344–3.855)), Being having BSc educational status (AOR = 2.554(1.465–4.452), marital status (AOR = 0.456(0.284–0.730)) and history of training (AOR = 1.976(1.233–3.168)) were significantly associated with the practice.
Conclusion
The study concluded that nurses working at west Arsi zone public hospitals had good knowledge and good practice. Educational background and work experience were associated with nurses’ knowledge. Age, Educational background, marital status, and history of training were associated with practice. The stake holders should focus on training, and continues nurses' professional development to improve knowledge and practice of non-pharmacological pain management.
Design and Analysis of Structure for Milling OCr13 Stainless Steel with Unequal Tooth Pitch Plunge Milling Tool
Authors: Li Junhua , Wang Yu , Gai Zhuxing , Jiang Lulu 
Published: October 2022

Abstract
Based on the theoretical analysis of the initial selection of tool parameters, the intrinsic model of stainless steel 0Cr13 material was constructed, and the simplified model was imported into Deform3D software, and after setting the corresponding parameters, the variation of milling force, milling temperature and tool wear of unequal pitch step plunge milling tool and common plunge milling tool were simulated. Then, according to the fuzzy matter-element theory, a fuzzy matter-element evaluation model was established for the plunge milling tool, and the values of milling force, acceleration and tool wear were measured by milling test, and the milling performance was compared between the unequal pitch step plunge milling tool and the common plunge milling tool by the fuzzy matter-element evaluation method. Milling force, acceleration and tool wear were reduced by 5%, 24% and 15%, respectively.
Verteporfin-induced proteotoxicity impairs cell homeostasis and survival in neuroblastoma subtypes independent of YAP/TAZ expression
Authors: Condurat Alexandra-Larisa , Aminzadeh-Gohari Sepideh , Malnar Mirjana , Thomas Ria , Menon Vishal , Kofler Barbara , Pruszak Jan 
Published: October 2022

Abstract
Neuroblastoma (NB) is a highly aggressive extracranial solid tumor in children. Due to its heterogeneity, NB remains a therapeutic challenge. Several oncogenic factors, including the Hippo effectors YAP/TAZ, are associated with NB tumorigenesis. Verteporfin (VPF) is an FDA-approved drug shown to directly inhibit YAP/TAZ activity. Our study aimed to investigate VPF’s potential as a therapeutic agent in NB. We show that VPF selectively and efficiently impairs the viability of YAP/ TAZ-expressing NB GI-ME-N and SK-N-AS cells, but not of normal fibroblasts. To investigate whether VPF-mediated NB cell killing is YAP-dependent, we tested VPF potency in CRISPR-mediated YAP/TAZ knock-out GI-ME-N cells, as well as YAP-negative BE(2)-M17 NB cells. Our data shows that VPF-mediated NB cell killing is not dependent on YAP expression. Moreover, we determined that the formation of high molecular weight (HMW) complexes is an early and shared VPF-induced cytotoxic mechanism in both YAP-positive and YAP-negative NB models. The accumulation of HMW complexes, involving STAT3, GM130 and COX IV proteins, impaired cell homeostasis and triggered cell stress and cell death mechanisms. Altogether, our study shows significant in vitro and in vivo VPF-induced suppression of NB growth, making VPF a potential therapeutic candidate against NB.
A cross-sectional study comparing emotional intelligence and perceived stress in groups of pharmacists delivering and not delivering a new community pharmacy service
Authors: Senćanski Dejan , Marinković Valentina , Tadić Ivana 
Published: October 2022

Abstract
Background:Community pharmacists (CPs) strongly contribute to public health and person-centered care. Emotional intelligence (EI) may help health professionals better engage with patients, handle stress in challenging situations, and presumably better introduce and implement new services. Such data in different CP populations do not exist.
Aim:The study's primary aim was to compare the EI and perceived stress (PS) levels in CPs providing a new service to patients with diabetes with their controls, CPs providing standard pharmaceutical care (PhC).
Method:Well-validated instruments were distributed electronically to all participating CPs. To compare the continuous EI and PS level data between the two study groups, the Independent Samples t-test, and Mann-Whitney U test was used. Pearson and Spearman’s correlations tested the associations between EI and PS and their respective sub-domains.
Results:A total of 86 CPs participated in the study. The study groups did not differ by any characteristics except gender, and their EI and PS levels did not differ. In both study groups, inverse correlations were found between PS and EI levels, with strong statistical significance in the control group.
Conclusion:Our study results suggest that the introduction of the EI agenda into the certification programs for new CP services should be considered. The results also suggest that higher EI may have protective effects against PS. Additional research with larger cohorts and a longitudinal design, including EI development intervention, would clarify the need to invest in CP-oriented EI programs more.