bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-criteria decision analysis (MCDA) tool for purchasing off-patent oncology medicines in Egypt
Authors: Elezbawy Baher , Fasseeh Ahmad Nader , Sedrak Amal , Eldessouki Randa , Gamal Mary , Eldebeiky Mariam , Amer Hanaa , Akeel Shimaa , Morsy Ahmad , Amin Amira , Shafik Amr , Abaza Sherif , Kaló Zoltán 
Published: March 2022

Abstract
Background
Multi- criteria decision analysis (MCDA) can assist policymakers in objectively choosing between alternative therapeutic options based on multiple value attributes. Our aim was to create an MCDA tool for the national tenders of off-patent oncology medicines in Egypt.

Methods
An initial list of criteria was developed through a literature review complemented by local expert interviews. Price or cost-related criteria were excluded to abide by the national regulations of the tender process. Next, a workshop hosting diversified stakeholders representing different governmental bodies was held. Anonymous voting was used to rank and weigh the criteria as well as assigning scores. Price was added as a separate step to identify best option based on price per point. The tool was then tested on a national tender sample of off-patent oncology medicines to assess its performance, and it was readjusted accordingly in a second workshop.

Results
Seven non-price criteria were selected, including use in reference countries (23.49% weight), equivalence with the reference product (18.79%), manufacturing quality (15.53%), provision of pharmacovigilance services (12.94%), supply reliability (10.78%), previous use in local settings (9.8%) and macroeconomic benefit (8.67%).
A medicine receives a score ranging from 0 to 100% of each criterion’s weight. The aggregated score is calculated on a hundred-point scale. Based on participants’ consensus, an overall score of 65 was set as a cut-off for passing the technical eligibility phase of the tendering process. Any product receiving a lower score would be disqualified from the tender. For qualified products, the lower price per point represents preferential option for the national tender.

Conclusions
The created MCDA tool is capable of objectively comparing similar off-patent oncology medicines by considering multiple value attributes and providing reliable scoring functions for each.
Patients’ dissatisfaction with multifocal intraocular lenses managed by exchange with other multifocal lenses of different optical profiles
Authors: Al-Shymali Olena , McAlinden Colm , Alio del Barrio Jorge L. , Canto-Cerdan Mario , Alio Jorge L. 
Published: March 2022

AbstractBackgroundThe aim of the study was to evaluate the outcomes of dissatisfied patients reporting poor visual quality following implantation of multifocal intraocular lenses (MF-IOLs), managed by IOL exchange with another multifocal optical profile.MethodsThis is a retrospective series of cases. MF-IOL exchange was done in 15 dissatisfied patients (30 eyes) with the perception of poor visual quality for far distance affected by neuroadaptation failure. Patients underwent a bilateral exchange of a MF-IOL with another MF-IOL of a different optical profile. Visual outcomes and complications were analyzed. Questionnaires including Quality of Vision (QoV), Visual Function Index-14 (VF-14) and its Rasch-revised version (VF-8R) and a satisfaction questionnaire were also used for outcome evaluation.ResultsThe mean elapsed time from implantation to explantation-reimplantation was 11.8 months. The QoV scores improved significantly across all the three subscales. Visual function improved with a change in VF-14 score from 60.41 ± 24.81 to 90.16 ± 10.91 (P < 0.001). The VF-8R score improved as well. The uncorrected distance visual acuity improved from 0.24 to 0.12 logMAR after exchange (P < 0.001) and corrected distance visual acuity improved from 0.15 to 0.04 logMAR (P < 0.001). Safety and efficacy indexes reached 1.46 and 1.16, respectively. Concerning patients’ satisfaction following MF-IOL exchange, 80% of the patients reported they would have the MF-IOL reimplantation procedure again.ConclusionsPatient dissatisfaction with neuroadaptation failure following MF-IOL implantation can be managed in 80% of our cases by MF-IOL exchange with a different MF-IOL optical profile.
Factors associated with survival of Iranian patients with COVID-19: comparison of Cox regression and mixture cure model
Authors: Seif Mozhgan , Sharafi Mehdi , Ghaem Haleh , Kasraei Farzaneh 
Published: March 2022

Abstract
Backgrounds
SARS-CoV-2 is almost the most problematic virus of this century. It has caused extensive damage to various economic, social, and health aspects worldwide. Nowadays, coronavirus disease 2019 (COVID-19) is the most dangerous threat to human survival. Therefore, this study aimed to investigate factors associated with the survival of Iranian patients with SARS-CoV-2.

Methods
This retrospective hospital-based cohort study was conducted on 870 COVID-19 patients with blood oxygen levels of less than 93%. Cox regression and mixture cure model were used and compared to analyze the patients’ survival. It is worth noting that no similar study has been previously conducted using mixture cure regression to model the survival of Iranian patients with COVID-19.

Result
The cure rate and median survival time were respectively 81.5% and 20 days. Cox regression identified that respiratory distress, history of heart disease and hypertension, and older age were shown to increase the hazard. The Incidence and Latency parts of the mixture cure model respectively revealed that respiratory distress, history of hypertension, diabetes and cardiovascular diseases (CVDs), cough, fever, and older age reduced the cure odds; also, respiratory distress, history of hypertension, and CVDs, and older age increased the hazard.

Conclusion
The findings of our study revealed that priority should be given to older patients with a history of diabetes, hypertension, and CVDs in receiving intensive care and immunization. Also, the lower cure odds for patients with respiratory distress, fever, and cough favor early hospitalization before the appearance of severe symptoms.
Factors associated with food consumption score among pregnant women in Eastern Ethiopia: a community-based study
Authors: Fite Meseret Belete , Tura Abera Kenay , Yadeta Tesfaye Assebe , Oljira Lemessa , Roba Kedir Teji 
Published: March 2022

Abstract
Introduction
Although assessing the nutritional status of pregnant women is becoming a common research agenda, evidence on food consumption scores, particularly among rural residents, is limited. This study aimed to assess the level of food consumption score and associated factors among pregnant women in Haramaya district, eastern Ethiopia, 2021.

Methods
A community-based cross-sectional study was conducted among 448 pregnant women in Haramaya district, eastern Ethiopia. Data were collected through face-to-face interviews by trained research assistants, using a validated food frequency questionnaire. Food consumption score, a proxy measure for food security, was assessed through a seven-day dietary recall of consumption of food items. Each food item was given a score of 0–7 depending on the number of days it was consumed then grouped into food groups and summed up each food group. The pregnant women were labeled as "acceptable food consumption score" when they had a food composite score of > 42 during the reference period. Otherwise, they were defined as "unacceptable." A Poisson regression model with robust variance estimation was used to investigate the association of the independent variables with the food consumption score. An adjusted prevalence ratio with a 95% confidence interval was reported to show an association using a p value < 0.05.

Results
The acceptable food consumption score among the study participants was 54.46% (95% CI 49–59%). The level of acceptable food consumption score was higher among respondents who were in the richest class (APR = 1.31; 95% CI 1.04–1.66), those who had ANC follow-up (APR = 1.78; 95% CI 1.40–2.27), those who had a favorable attitude toward dietary practice (APR = 1.30; 95% CI 1.12–1.52), and those who consumed high animal source foods (APR = 1.28; 95% CI 1.01–1.51). However, acceptable food consumption score was lower among women who were not owned agricultural land (APR = 0.84; 95% CI 0.72–0.99).

Conclusion
We found a low acceptable food consumption score among pregnant women in this predominantly rural setting. Nutritional counseling in pregnancy should address the importance of food diversity and consumption of animal source foods to improve nutrition in pregnancy. Our findings highlight the imperative requirement for policies and programs to support farmers who had no farmland to improve their overall food security and maximize their food consumption score. Assessing perinatal outcomes associated with food consumption score is essential for unraveling the spectrum of nutrition in pregnancy and beyond.
Dark-field chest x-ray imaging: first experience in patients with alpha1-antitrypsin deficiency
Authors: Zimmermann Gregor S. , Fingerle Alexander A. , Renger Bernhard , Laugwitz Karl-Ludwig , Hautmann Hubert , Sauter Andreas , Meurer Felix , Gassert Florian Tilman , Bodden Jannis , Müller-Leisse Christina , Renz Martin , Rummeny Ernst J. , Makowski Marcus R. , Willer Konstantin , Noichl Wolfgang , De Marco Fabio , Frank Manuela , Urban Theresa , Schick Rafael C. , Herzen Julia , Koehler Thomas , Haller Bernhard , Pfeiffer Daniela , Pfeiffer Franz 
Published: March 2022

Abstract
Background
Spirometry and conventional chest x-ray have limitations in investigating early emphysema, while computed tomography, the reference imaging method in this context, is not part of routine patient care due to its higher radiation dose. In this work, we investigated a novel low-dose imaging modality, dark-field chest x-ray, for the evaluation of emphysema in patients with alpha1-antitrypsin deficiency.

Methods
By exploiting wave properties of x-rays for contrast formation, dark-field chest x-ray visualises the structural integrity of the alveoli, represented by a high signal over the lungs in the dark-field image. We investigated four patients with alpha1-antitrypsin deficiency with a novel dark-field x-ray prototype and simultaneous conventional chest x-ray. The extent of pulmonary function impairment was assessed by pulmonary function measurement and regional emphysema distribution was compared with CT in one patient.

Results
We show that dark-field chest x-ray visualises the extent of pulmonary emphysema displaying severity and regional differences. Areas with low dark-field signal correlate with emphysematous changes detected by computed tomography using a threshold of -950 Hounsfield units. The airway parameters obtained by whole-body plethysmography and single breath diffusing capacity of the lungs for carbon monoxide demonstrated typical changes of advanced emphysema.

Conclusions
Dark-field chest x-ray directly visualised the severity and regional distribution of pulmonary emphysema compared to conventional chest x-ray in patients with alpha1-antitrypsin deficiency. Due to the ultra-low radiation dose in comparison to computed tomography, dark-field chest x-ray could be beneficial for long-term follow-up in these patients.
Dynamic profiles of DNA methylation and the interaction with histone acetylation during fiber cell initiation of Gossypium hirsutum
Authors: CHEN Guangyu , LI Yonghui , WEI Zhenzhen , GAN Lei , LIU Jisheng , WANG Zhi 
Published: March 2022

Abstract
Background
Fiber, as the main product of cotton, provides main raw material for the textile industry. Many key factors have been revealed a significant role in fiber cell development including Myb proteins, phytohormones, fatty acid metabolites, and epigenetic modifications. DNA methylation is one of the important epigenetic modifications to regulate plant development and responses to abiotic or biotic stimuli. In general, DNA methylation consisting of 5mC and 6mA regulates the chromatin structure and gene transcription to affect plant development, however, the detailed role and underlying mechanism of DNA methylation in the fiber development of cotton are yet vague.

Results
Here, systematical study of the 5mC and 6mA DNA methylation profiles during the fiber initiation period of Xu142 and its glabrous mutant Xu142fl represented a clear alteration of global DNA methylation associated with fiber cell initiation. Then, the genome-wide identification of genes responsible for methylation regulation at the fifth carbon of cytosine and the sixth carbon of adenine of DNA was operated in Gossypium hirsutum. As a result, 13, 10, 6, and 17 genes were identified for 5mC methylation, 5mC demethylation, 6mA methylation, and 6mA demethylation, respectively. We then investigated the tissue expression pattern of all these genes, and some genes showed higher expression levels in fiber initiation, among which some displayed a significant change in transcription between Xu142 and Xu142fl. The possible interaction between histone acetylation and DNA methylation in fiber initiation through in vitro culture was studied by dot blot, and the results showed that repressed histone deacetylation by Trichostatin A (TSA) inhibited the global DNA methylation, and some causal genes (e. g., GhDMT13, GhDAMT2, GhALKBH12, GhDM7) were also identified.

Conclusions
In this study, all the findings indicated the interplay between histone acetylation and DNA methylation, supporting their important roles and providing precious clues for the epigenetic modifications associated with DNA methylation in the fiber development of cotton.
Blockchain abnormal behavior awareness methods: a survey
Authors: Yan Chuyi , Zhang Chen , Lu Zhigang , Wang Zehui , Liu Yuling , Liu Baoxu 
Published: March 2022

AbstractWith the wide application and development of blockchain technology in various fields such as finance, government affairs and medical care, security incidents occur frequently on it, which brings great threats to users’ assets and information. Many researchers have worked on blockchain abnormal behavior awareness in respond to these threats. We summarize respectively the existing public blockchain and consortium blockchain abnormal behavior awareness methods and ideas in detail as the difference between the two types of blockchain. At the same time, we summarize and analyze the existing data sets related to mainstream blockchain security, and finally discuss possible future research directions. Therefore, this work can provide a reference for blockchain security awareness research.
The Pseudomonas syringae effector AvrPtoB targets abscisic acid signaling pathway to promote its virulence in Arabidopsis
Authors: Liu Yanzhi , Mahmud Md. Rubel , Xu Ning , Liu Jun 
Published: March 2022

AbstractPhytohormones play an essential role in plant immune responses. Many phytopathogens secret effector proteins to promote infection and plant hormone signaling pathways are considered to be the potential targets of effectors. Here we found that abscisic acid (ABA) signaling was activated rapidly upon infection with Pseudomonas syringae pv. tomato (Pst). Pst secretes the effector AvrPtoB to target ABA 8′-hydroxylase CYP707As for degradation in Arabidopsis thaliana. CYP707As hydroxylate ABA to an inactive form. The degradation of CYP707As resulted in ABA accumulation and compromised plant immune responses. Our study demonstrated that Pst could hijack the key components of Arabidopsis ABA signaling pathway to cause disease.
The first combined meta‐analytic approach for elucidating the relationship of circulating resistin levels and RETN gene polymorphisms with colorectal and breast cancer
Authors: Aziz Md. Abdul , Akter Tahmina , Sarwar Md. Shahid , Islam Mohammad Safiqul 
Published: March 2022

Abstract
Background
Evidence suggests that circulating resistin levels are altered in colorectal cancer (CRC) and breast cancer (BC). Again, polymorphisms in resistin-encoding gene RETN have been evaluated in CRC and BC. However, there is a scarcity of data establishing the relationship of resistin and RETN polymorphisms (rs1862513 and rs3745367) with these cancers. This study aimed to analyze the relationship of resistin levels and RETN polymorphisms with CRC and BC in a combined meta-analytic approach.

Main body of the abstract
After a comprehensive online literature search, screening and eligibility check, 41 articles (31 with resistin level and 10 with RETN polymorphisms) were retrieved for meta-analyses. The mean difference (MD) of resistin was calculated and pooled to investigate the effect sizes with a 95% confidence interval (CI), and the connection of genetic polymorphisms was analyzed with an odds ratio (OR) and 95% CI. The analysis showed that resistin level is significantly higher in CRC (MD = 3.39) and BC (MD = 3.91) patients. Subgroup analysis in CRC showed significantly higher resistin in serum (MD = 4.61) and plasma (MD = 0.34), and in BC, a significantly elevated resistin level was reported in premenopausal (MD = 7.82) and postmenopausal (MD = 0.37) patients. Again, RETN rs1862513 showed a significantly strong association with CRC (codominant 1—OR 1.24, codominant 2—OR 1.31, dominant model—OR 1.25, and allele model—OR 1.16) and with BC (codominant 2—OR 1.51, codominant 3—OR 1.51, recessive model—OR 1.51, and allele model—OR 1.21). RETN rs3745367 did not show any association with these cancers.

Short conclusion
Overall, our analysis indicates that higher circulating resistin levels are associated with an elevated risk of CRC and premenopausal and postmenopausal BC. Besides, rs1862513 in RETN gene is significantly connected with both CRC and BC.
Discrimination between phyllodes tumor and fibro-adenoma: Does artificial intelligence-aided mammograms have an impact?
Authors: Mansour Sahar , Kamel Rasha , Marey Ahmed , Hunold Christiane , Yousry Ahmed 
Published: March 2022

Abstract
Background
The indulgence of artificial intelligence (AI) has been considered recently in the work up for the detection and diagnosis of breast cancer through algorithms that could supply diagnosis as the radiologist do. The algorithm learns from a supervised and continuous input of large and new data sets unlike the standard programming, which requires clear step-by-step instructions. The aim of this study is to assess the ability of AI scanned mammograms to aid the ultrasound in the discrimination between phyllodes tumors and fibro-adenomas.

Results
This is a retrospective analysis included 374 proven phyllodes tumors (PT) and fibro-adenomas (FA). Digital mammogram and breast ultrasound was performed for all the cases and each breast was given a “Breast Imaging Reporting and Data System” (BI-RADS) score. Included mammograms were scanned by AI with resultant a qualitative heatmap and a quantitative abnormality scoring of suspicion percentage.
The study included 164 PT (43.9%) and 210 FA (56.1%). BI-RADS category 2 was assigned in 40.1%, category 3 in 38.2%, category 4 in 18.5% and category 5 in 3.2% with median value of the AI abnormality scoring of 23%, 44%, 65% and 90% respectively. Sensitivity and specificity of the conventional imaging were 59.2% and 75.8% respectively. The AI abnormality scoring of 49.5% upgraded the sensitivity to 89.6% and specificity to 94.8% in the ability to discriminate PT from FA masses.

Conclusion
Artificial intelligence-aided mammograms could be used as method of distinction between PT from FA detected on sono-mammogram. The color hue and the quantification of the abnormality scoring percentage could be used as a one setting method for specification and so guide clinicians in their decision of conservative management or the choice of the surgical procedure.
Overview of Adult Sarcoma Burden and Clinical Pathways in Brazil
Authors: David Bruna Bianca Lopes , Abdon Mello Celso , Santos Thuler Luiz Claudio , de Melo Andreia Cristina 
Published: March 2022

PURPOSE Sarcomas are a heterogeneous group of cancers classified as rare cancers and are often poorly characterized. In Brazil, little is known about the adult sarcoma burden and patients' clinical pathways. MATERIALS AND METHODS We analyzed data from the Brazilian Hospital–Based Cancer Registries System, which encompasses the entire country. The histologic criteria included sarcomas according to the International Classification of Diseases for Oncology, 3rd edition. All cases were histology-based. No central pathology review was performed. Patients < 18 years old were excluded. The variables were analyzed according to the center type, hospital patient volume (> 70 patients/year for 3 consecutive years), and geographical region. The results were based on valid data, and the missing values were reported. RESULTS From 2000 to 2017, a total of 312 units and 49,878 cases were identified. Missing data proportion was stable. Soft tissue sarcomas were predominant, followed by bone sarcomas and gastrointestinal stromal tumors. The Southeast concentrated on the largest number of patients (51%), of high-complexity centers (CACONs; 52%), and of patients treated at CACONs (56.9%). In all regions, the majority of patients had localized disease at diagnosis. The proportion of patients starting their treatment within 60 days from diagnosis at CACON was 59.3% and 62.3% at others. Ten hospitals achieved the established threshold for high-volume center, of which seven were CACON. CONCLUSION This article highlights the need for further research on the profile of patients with sarcoma in Brazil and the importance of providing them a more effective diagnostic and therapeutic approach. This initiative is critical not just for planning treatment strategies but also to allocate medical resources and to improve quality of care and sarcoma patients outcomes.