bluuebunny/crossref_metadata_2025_split huggingface dataset:
The asymmetric impact of oil price uncertainty on emerging market financial stress: A quantile regression approach
Authors: Das Debojyoti , Dutta Anupam , Jana Rabin K. , Ghosh Indranil 
Published: June 2022

AbstractThis study investigates the effects of the crude oil implied volatility index (OVX) upon emerging market financial stress (EMFS). We resort to a quantile regression framework as this approach is a better alternative to disentangle the relationship under different market conditions. Besides, we also examine how EMFS responds to the lags and asymmetries in the OVX. The empirical results show significantly positive impacts of OVX upon EMFS. Further, the effects of OVX become more assertive in the upper quantiles of EMFS, implying higher sensitivity to OVX when stress levels are high. In terms of the lagged effects, the relationship is transient as the OVX coefficients become weaker with increasing lag sizes. We further find that only positive impulses in OVX can significantly predict EMFS. Lastly, we report evidence that the Credit market stress is a crucial driver of EMFS.
Fair value hierarchy, bargaining power, and audit pricing across audit firms’ client portfolios
Authors: Clark Stanley , Vagner Brandon , Ward Terry 
Published: June 2022

AbstractThis study explores how the presence of Level 2 and/or 3 fair value assets (FVA_23) influences audit pricing across small and large clients for Big‐4 and non‐Big‐4 audit firms. Through analysis of 7918 firm‐year observations, we investigate whether companies with FVA_23 incur higher audit fees than companies without FVA_23 and the differences between how Big‐4 and non‐Big‐4 firms price risk for large and small companies. Our theoretical basis is product differentiation and economic importance, which suggest competing influences on audit fees based on firm and company size. We are the first to analyze the effect of FVA_23 on audit fees with the United States sample including all industries during a stabilized regulatory period, and we are the first to explore the effect of FVA_23 on audit pricing across small and large audit clients for Big‐4 and non‐Big‐4 firms. We find companies with FVA_23 incur higher audit fees than companies without FVA_23. More specifically, we find small and large companies realize different audit fees compared to companies of similar size without FVA_23. Additionally, Big‐4 and non‐Big‐4 firms price audits with FVA_23 differently than audits without FVA_23. Furthermore, Big‐4 and non‐Big‐4 audit pricing is influenced by FVA_23 differently based on company size.
Ligand‐assisted imprinting‐probe‐labeling strategy reveals Siglec‐7 ‐ glycoprotein interactions
Authors: Li Pei‐Jhen , Kawade Sachin Kisan , Adak Avijit K. , Shen Yu‐Ju , Fan Chen‐Yo , Hsieh Yu‐Heng , Angata Takashi , Chen Yu‐Ju , Lin Chun‐Cheng 
Published: June 2022

AbstractThe development of a ligand‐assisted imprinting probe (i.e., LIP 1) for the site‐specific labeling of recombinant Siglec‐7 protein (rSiglec‐7) is reported. LIP 1 is a LIP bearing a ganglioside GD3 glycan, a natural ligand for Siglec‐7, that is embedded in an ortho‐hydroxyl cinnamate core, which exhibits UV‐light‐dependent conformational changes, and is appended with a clickable alkyne handle. LIP 1 enables the selective introduction of an alkyne at the threonine residue 91 (Thr91), which is proximal to the carbohydrate‐binding pocket of Siglec‐7, as identified by LC–MS/MS analysis. By using LIP 1, an azide‐containing environment‐sensitive merocyanine dye is conjugated to rSiglec‐7 by a click reaction, which is capable of directly imaging live HeLa cells as a result of highly specific interactions with cell‐surface glycoproteins containing sialic acid. Moreover, the conjugation of doxorubicin (Dox) to alkynylated rSiglec‐7 retains the original activity of protein binding to the interacting natural GD3 glycan ligand, as revealed by microarray analysis; hence, the rSiglec‐7 conjugate can serve as cargo (Dox)‐delivery vehicle to Siglec‐ligand‐expressing HeLa cells. The LIP labeling strategy described herein is expected to be a general strategy for the future development of glycoprobes for investigating lectin‐glycan interactions.
Preparation of rGO‐CNT/Ag3PO4/Nb2O5 composite with enhanced photoresponse properties as a highly effective visible light driven photocatalyst
Authors: Alijani Hassan , Kaveh Reyhaneh 
Published: June 2022

AbstractIn this study a facile method to synthesize a new type of photocatalyst by coating Ag3PO4/Nb2O5 composite on rGO‐CNT network was reported. The composite of Silver orthophosphate/Niobium(V) oxide (Ag3PO4/Nb2O5) was prepared through depositing Ag3PO4 particles on the surface of Nb2O5 particles. The prepared Ag3PO4/Nb2O5 composite photocatalyst shows a much higher photocatalytic activity for the degradation of MB than pure Ag3PO4 and Nb2O5 under simulated sunlight. This can be related to the efficient separation of photoinduced electron/hole pairs derived from the Ag3PO4/Nb2O5 heterojunction. Moreover, the prepared reduced Graphene Oxide‐Carbon nanotube (rGO‐CNT) network inhibits the restacking of sheets of Graphene Oxide (GO) during the reduction process and can create fast electronic conducting channels, making this an effective strategy for improving the photocatalytic performance of the prepared composite of Ag3PO4/Nb2O5. The degradation rate constant (kapp) of the optimized rGO‐CNT/Ag3PO4/Nb2O5 photocatalyst was higher by a factor of 6.7 times than that of the corresponding Ag3PO4 nanoparticles. The synergistic interactions between Ag3PO4, Nb2O5, and the presence of rGO‐CNT network lead to an increased surface area, a decreased aggregation of the particles, a reduced recombination rate for the photogenerated electron/hole pairs, and an efficient charge carrier transfer. In addition, no loss of photocatalytic activity was observed after six recycles. © 2022 Society of Chemical Industry (SCI).
Strain‐mediated electrical and optical properties of novel lead‐free CuFe2O4–KNbO3 nanocomposite solid solutions: A combined experimental and Density Functional Theory studies
Authors: I. B. Shameem Banu , Raman Rajesh , Mamat Mohamad Hafiz , P. Komalavalli , B. H. Poornima , S. Divyalakshmi , S. Sathik Basha , A. Sathya Priya , Hussain Shamima 
Published: June 2022

AbstractThis article summarizes the strain‐mediated electrical and optical properties of novel lead‐free xCuFe2O4 (1 − x) KNbO3 (x = 0.2, 0.3, and 0.4) multiferroic nanocomposite through a solid state route. X‐ray diffraction analysis divulges the influence of interfacial strain in the KNbO3–CuFe2O4 matrix and shows the coexistence of orthorhombic and cubic spinel phases, respectively. Morphological analysis reveals that the average particle size of 0.3CuFe2O4–0.7KNbO3 is 25 nm which is smaller than the other two nanocomposites. The UV–visible absorption studies and Raman spectroscopy of 0.3CuFe2O4–0.7KNbO3 nanocomposite present the high energy bandgap and electro coupling of KNbO3 and CuFe2O4 phases. The DFT theoretical bandgap behaviors of all the three nanocomposites synchronize with the experimental bandgap results. Dielectric, ferroelectric and magnetoelectric behaviors are also improved in 0.3CuFe2O4–0.7KNbO3 nanocomposite as compared to pristine KNbO3 and the other two nanocomposites.Highlights

This article summarizes the strain‐mediated electrical and optical properties of novel lead‐free xCuFe2O4–(1 − x) KNbO3 (x = 0.2, 0.3, and 0.4) multiferroic nanocomposite through a solid state route.
X‐ray diffraction analysis divulges the influence of interfacial strain in the KNbO3–CuFe2O4 matrix and shows the coexistence of orthorhombic and cubic spinel phases, respectively.
The 0.3CuFe2O4–0.7 KNbO3 nanocomposite shows a remarkable increase in the optical bandgap, remnant polarization, dielectric permittivity, and magnetoelectric coefficient compared to the other two nanocomposites.
DFT calculations on KNbO3–CuFe2O4 matrix reveal the impact of diffusion between two phases and support the bandgap experimental results.
Intermittent neurologic decompensation: An underrecognized presentation of tyrosine hydroxylase deficiency
Authors: Champagne Marjolaine , Horvath Gabriella A. , Perreault Sébastien , Gauthier Julie , Hyland Keith , Soucy Jean‐François , Mitchell Grant A. 
Published: June 2022

AbstractTyrosine hydroxylase deficiency (THD) is a treatable inborn error of dopamine biosynthesis caused by mutations in TH. Two presentations are described. Type A, milder, presents after 12 months of age with progressive hypokinesis and rigidity. Type B presents before 12 months as a progressive complex encephalopathy. We report a girl with mild THD who had recurrent episodes of neurological decompensations. Before the first episode, she had normal development except for mild head tremor. Episodes occurred at 12, 19, and 25 months of age. After viral infections or vaccination, she developed lethargy, worsened tremor, language, and motor regression including severe axial hypotonia, recuperating over several weeks of intensive rehabilitation but with residual tremor and mild lower limb spasticity. Basal ganglia imaging was normal. Exome sequencing revealed two missense variants of uncertain significance in TH: c.1147G>T and c.1084G>A. Both have low gnomAD allele frequencies and in silico, are predicted to be deleterious. Cerebrospinal fluid analysis showed low homovanillic acid (HVA, 160 nmol/L, reference 233–938) and low HVA/5‐hydroxyindolacetic acid molar ratio (1.07, reference .5–3.5). She responded rapidly to L‐Dopa/carbidopa without further episodes. Literature review revealed four other THD patients who had a total of seven episodes of marked hypotonia and motor regression following infections, occurring between ages 12 months and 6 years. All improved with L‐Dopa/carbidopa treatment. Intermittent THD is treatable, important for genetic counseling, and should be considered after even a single episode of marked hypotonia with recuperation over weeks, especially in patients with preexisting tremor, dystonia, or rigidity.
Modeling knowledge management for job satisfaction improvement
Authors: Kavalić Mila , Stanisavljev Sanja , Mirkov Smiljana , Rajković Jelena , Terek Stojanović Edit , Milosavljev Dragana , Nikolić Milan 
Published: June 2022

AbstractThis paper analyzes the influence and predictive effects of knowledge management on job satisfaction. The aim of this paper is to develop a model based on the effects of knowledge management on job satisfaction. The data were obtained by interviewing 520 managers of all levels from manufacturing enterprises in Serbia. The results showed that knowledge management has a complex influence on job satisfaction. It negatively affects the dimensions of Salary, Promotion, and Supervision and positively influences the Additional Benefits dimension, while having combined effects on the other dimensions. In a working environment where knowledge management levels are high, employees may perceive their salaries, rewards, and promotion opportunities as inadequate. This is because they feel they deserve more due to their knowledge, ability, engagement, and the enterprise's success. Serbian enterprises are often unable to pay their employees higher salaries. The theoretical importance of the results is precisely in the fact that the individual relations of the observed dimensions are determined and that the desired model is developed. The practical significance of the work is that leaders and managers, based on these relations, can see the possibilities and ways to improve certain aspects of knowledge management and job satisfaction.
Evaluation of the long‐term results of vascular anastomosis using polyurethane adhesive and shape‐memory stent in the rat carotid artery model
Authors: Heitzer Marius , Ooms Mark , Katz Marie Sophie , Peters Florian , Kilic Konrad , Tolba René , Jockenhoevel Stefan , Hermanns‐Sachweh Benita , Hölzle Frank , Modabber Ali 
Published: June 2022

AbstractIntroductionIn free flaps, 5%–10% of complications are related to failure of sutured vascular anastomoses. Adhesive‐based microvascular anastomoses are potential alternatives but are associated with failure rates of 70% in research studies. VIVO is a new adhesive with slow biodegradation within 6 months that has shown a 100% patency rate in research studies over 2 h observation time but long‐term patency has not been evaluated. The authors hypothesize that VIVO will enable a reliable microvascular procedure comparable to sutured anastomoses over a 28‐day period.Materials and MethodsThe right common carotid artery of 60 male Sprague Dawley rats, ~450 g, were used for microvascular end‐to‐end anastomosis. VIVO was applied with reduced sutures with a temporary catheter in one group and in the other with a custom‐shaped memory stent. Anastomoses with eight interrupted sutures served as control. All groups were n = 20. Anastomosis time and bleeding were recorded for each procedure. Doppler flowmetry was performed 20 min, 1, 10, and 28 days postoperatively. Postmortem toluidine staining was used for semi‐quantitative analysis of stenosis, thrombosis, necrosis, and aneurysm formation by histologic evaluation.ResultsNo occlusion was detected 20 min and 1 day postoperative, and after 28 days of observation in all anastomoses. The anastomosis time of the VIVO with catheter group was about 32% significantly faster than the VIVO with stent group. In the VIVO group with stent, the bleeding time was ~80% shorter than in the control group with 2.1 ± 0.3 and VIVO with catheter 2.0 ± 0.5 (p ≤ .001 each). Minor and nonsignificant stent‐associated thrombus formation and stent‐typical intraluminal stenosis were detected exclusively in the VIVO with stent group.ConclusionWithin the limitations of a rat study, the use of VIVO in anastomosis showed promising results. VIVO with catheter was found to be advantageous.
Identifying Chirality in Line Drawings of Molecules Using Imbalanced Dataset Sampler for a Multilabel Classification Task
Authors: Kok Yong En , Woodward Simon , Özcan Ender , Torres Torres Mercedes 
Published: June 2022

AbstractChirality, the ability of some molecules to exist as two non‐superimposable mirror images, profoundly influences both chemistry and biology. Advances in deep learning enable the automatic recognition of chemical structure diagrams, however, studies on discovering the molecule chirality are scarce and the machine‐readable molecular representations are not always sufficient to fully support the encoding of this important property. Here, we pretrained networks on a ChEMBL+ dataset (79641 molecules) and fine‐tuned them for the binary classification of chirality (achiral/chiral) or multilabel chirality type classifications (none/centre/axial/planar). To address the label combination imbalanced problem in the multilabel task, the study proposed a Formulated Imbalanced Dataset Sampler (FIDS) to sample a formulated amount of minority label combinations on top of the training set. On a 10‐fold cross validation experiment using our CHIRAL dataset (1142 manually curated molecules), our models achieved up to an accuracy of 90 % in the binary task. In the multilabel task incorporated with FIDS, the overall performance increases from 87 % to 89 % and the accuracy per label combination can attained up to a 50 % increase. Through the study of heatmaps, our work also exemplified the potential of deep neural network to make predictions based on the actual location of chirality elements.
Prenatal detection and evaluation of differences of sex development: A qualitative interview study of parental perspectives and unmet needs
Authors: Whitehead J , Hirsch Josephine , Rosoklija Ilina , Goetsch Weisman Allison , Dungan Jeffrey , Finlayson Courtney , Chen Diane , Johnson Emilie K. 
Published: June 2022

AbstractObjectivesPrenatal diagnoses of differences of sex development (DSD) are increasing due to availability of cell‐free DNA screening (cell‐free DNA screening (cfDNA)). This study explores first‐hand experiences of parents whose children had prenatal findings of DSD.MethodsEligible parents were identified through chart review at a pediatric center and interviewed about their prenatal evaluation, decision making, informational sources, and support systems. Interviews were coded using a combined inductive and deductive thematic analysis. Parents also completed quantitative measures of decisional regret.ResultsSeventeen parents (13 mothers; 4 fathers) of 13 children (with 7 DSD diagnoses) were recruited. Four children had discordance between sex predicted by cfDNA versus prenatal ultrasound, and 2 had non‐binary appearing (atypical) genitalia on prenatal ultrasound. Of these 6, 3 were not offered additional prenatal testing or counseling.Most parents described tension between obtaining support through disclosure of their child's diagnosis and preserving their child's autonomy/privacy, highlighting the need for mental health support.ConclusionThis is the first study to gather qualitative data from parents whose children had prenatal findings of DSD. We identified multiple targets for intervention to improve care for patients with DSD across the lifespan, including improvements in clinician education, pre‐ and post‐test counseling, and patient education materials.
Chronic bronchiectasis complicated with benign jejuno‐ileal pneumatosis intestinalis
Authors: Wei Sheng‐Huan , Huang Li‐Ting , Huang Tang‐Hsiu 
Published: June 2022

AbstractPatients with chronic bronchiectasis are susceptible to various respiratory complications. In this report, however, we describe a 53‐year‐old male with chronic bronchiectasis who developed extensive but asymptomatic jejuno‐ileal pneumatosis intestinalis. The patient did not have preceding pneumothorax or pneumomediastinum, and he did not receive cytotoxic or immunosuppressive therapy. Nor did he exhibit any clinical or radiographic evidence of intestinal ischaemia, obstruction or infection. Mucosal defects, due to his severe diarrhoea relating to the prolonged anti‐pseudomonal antibiotic treatment for his lungs, and the intestinal luminal pressure fluctuation, resulting from his exacerbated cough and from his frequent abdominal straining during defecation, were considered to have precipitated the condition. Following conservative treatment, the patient recovered well. In addition to adverse respiratory events, clinicians managing patients with bronchiectasis should also be alert to such an unusual extrapulmonary complication, because either neglecting the condition or unnecessary exploratory surgery may lead to hazardous outcomes.
Rare case of cystic anterior mediastinal tuberculosis in an immunocompetent patient
Authors: Butler Jessica , Barry Simone 
Published: June 2022

AbstractWe report a case of a 28‐year‐old immunocompetent woman found to have a mediastinal lesion on chest x‐ray performed as part of a visa renewal process. Computed tomographic imaging revealed a cystic superior anterior mediastinal mass. Although initially asymptomatic, the woman subsequently developed progressive chest discomfort. She underwent surgical resection of the mass. Histological assessment demonstrated necrotizing granulomatous inflammation, while Gene Xpert™ testing was positive for Mycobacterium tuberculosis complex and she was subsequently commenced on anti‐tuberculous therapy.
Atezolizumab in combination with carboplatin plus nab‐paclitaxel for managing combined large‐cell neuroendocrine carcinoma: A case report
Authors: Tsutsumi Rei , Kataoka Nobutaka , Kunimatsu Yusuke , Sato Izumi , Tanimura Mai , Nakano Takayuki , Tanimura Keiko , Takeda Takayuki 
Published: June 2022

AbstractLarge‐cell neuroendocrine carcinomas (LCNECs), categorized as high‐grade neuroendocrine carcinomas, account for approximately 3% of resected lung cancers. LCNECs containing other components are called ‘combined LCNECs’ and have no standard treatment. A 73‐year‐old male with a metastatic brain tumour from a combined LCNEC of the lung containing adenocarcinoma and sarcomatoid components was referred to our department. The patient was treated with chemotherapy consisting of carboplatin and nanoparticle albumin‐bound (nab)‐paclitaxel in combination with atezolizumab, which was decided in accordance with the histological evaluation of the components. This treatment resulted in partial response and remained durable for 12 months with an ongoing regimen. The current case suggests that the constituents of chemoimmunotherapy should be selected in accordance with the reported efficacy of relevant regimens for each component of the combined LCNEC.
Model‐based event‐triggered neural learning control for discrete‐time strict‐feedback systems
Authors: Shi Haotian , Wang Min , Wang Cong 
Published: June 2022

AbstractIn this article, the model‐based event‐triggered neural learning control problem is investigated for a class of discrete‐time strict‐feedback systems. First, with the case of sufficient network resources, an adaptive neural controller is designed with a new neural weight update law, which avoids the ‐step delay of traditional adaptive neural control methods. The proposed controller performs the tracking control task while ensuring that the radial basis function neural network can accurately identify the unknown system nonlinear dynamics and the estimated neural weights can converge to their ideal values. Second, with the case of limited network resources, the convergent neural weights can be reused to construct the neural network model, event‐trigger conditions, and the neural learning controller, which can improve the tracking control performance and save the communication resources. Especially, compared with the traditional event‐triggered adaptive neural controller, the neural learning controller can reduce the burden of online calculations since the constant neural weights are used to construct the neural network model and trigger conditions. For the proposed control scheme, simulation results are given to verify its effectiveness.
Flexible MXene‐Based Composite Films: Synthesis, Modification, and Applications as Electrodes of Supercapacitors
Authors: Luo Yijia , Que Wenxiu , Bin Xiaoqing , Xia Chenji , Kong Bingshan , Gao Bowen , Kong Ling Bing 
Published: June 2022

AbstractMXenes, as a 2D planar structure nanomaterial, were first reported in 2011. Due to their large specific surface area, high ductility, high electrical conductivity, strong hydrophilic surface, and high mechanical flexibility, MXenes have been extensively explored in the development of various functional materials with desired performances. This review is aimed to summarize the current progress in synthesis, modification, and applications of MXene‐based composite films as electrode materials of flexible energy storage devices. In the synthesis of MXenes, the evolution and exploration of etchants are emphasized. Furthermore, in order to develop MXene‐based composite films, the components used to modify the MXene nanoflakes, including 0D, 1D, and 2D nanomaterials, are summarized, and the perspectives and research direction of such materials are also discussed.