bluuebunny/crossref_metadata_2025_split huggingface dataset:
OAGB with shortened excluded ileal loop as an effective treatment for type 2 diabetes mellitus in the cases of Caucasian Men and Women with obesity of the first degree (BMI 30-35 kg/m2)
Authors: Jaworski Paweł , Binda Artur , Barski Krzysztof , Wawiernia Karolina , Kudlicka Emilia , Wąsowski Michał , Jankowski Piotr , Tarnowski Wiesław 
Published: August 2022

Abstract
Introduction: The aim of the study is to assess long-term results of surgical treatment (One Anastomosis Gastric Bypass) of type 2 diabetes in patients with Io obesity. Material and Methods: The study included 25 patients with BMI 30-35 kg / m2 and diagnosed diabetes mellitus type 2 undergoing OAGB with excluded 150 cm of the small intestine (this is one of the innovative elements of this work).Results: There were no: deaths in the study group, bleeding during the postoperative period requiring reoperation, anastomotic leak/leakage of mechanical stitching. The mean HbA1C level 12 months after surgery is 6.16 ± 0.96%, the decrease was 2.29 ± 3.3%. In more than 85% of patients taking insulin before surgery, it was discontinued in the postoperative period. Additionally, the level of glycaemia was assessed in patients on the day of surgery (163 ± 58 mg%) and on the day of discharge from the hospital (4.7 ± 1.3 day) - it was lower by over 18% (133 ± 39.2 mg). Over the period of 12 months following OAGB: reduction in the mean BMI value from 33.5 ± 2 kg / m2 to 25.5 ± 2.5 kg / m2, improvement in lipid parameters and mean values of blood pressure.Conculsion: OAGB with excluded 150 cm of the small intestine has beneficial effect on resolution of T2DM in patients with BMI of 30-35kg/m2 and is associated with an acceptable level of complications. Achieved weight loss after surgery is satisfactory.
Towards roadmap to implement blockchain-oriented solution artifact for secured transactions: a remittance management perspective
Authors: Weerawarna Rashikala , Miah Shah J 
Published: August 2022

Abstract
Block chain has become a popular distributed ledger technology, which assists to store data in a secured, tamper proofed and immutable manner. In recent years, banks and remittance institutes have shown their interests increasingly to investigate the application design issues related to this disruptive technology, for instance, by evaluating the competitive advantage of using the applications over the tradition banking and remittance industry. Gaining opportunities of the block chain, however, is a challenge for international remittance due to the lack of relevant knowledge of business integration, security, regulatory requirements, technological improvements in mining hardware requirements and social trust.It is imperative to develop application design understanding that may be assistive to gain the actual benefit of the block chain in remittance management. Aiming to offer new knowledge for academics, researchers, business owners, government, FinTech companies and general public users elaborating interplaying business, technical and social requirements, this paper presents a design research approach that guides the development of a novel block chain-oriented remittance model for Australian remittance companies. This paper reports on a preliminary design which can be considered as a first proof-of-concept prototype. We identify key requirements of designing a secured, faster, user-friendly and responsive options for delivering secured transparency of financial transactions for stakeholders, which are to be complying with Know Your Customer (KYC) and Anti-Money Laundering (AML) regulations.
Risk factors of primary poor graft function after allogeneic hematopoietic stem cell transplantation in patients with myeloid tumors
Authors: ZHANG Lin-Yi , XIONG Yi-Ying , LIAO Ming-Yan , Qing XIAO , TANG Xiao-Qiong , Xiao-Hua LUO , ZHANG Hong-Bin , Li WANG , Lin LIU 
Published: August 2022

Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy but can result in significant complications including poor graft function (PGF). Little is known about the risk factors of primary PGF occurring after allo-HSCT. We retrospectively analyze the clinical data of 146 patients with myeloid tumors who underwent allo-HSCT at our hospital from January 2015 to December 2021. The relevant clinical parameters affecting the occurance of primary PGF after allo-HSCT were selected for univariate and multivariate analysis. Then, the difference in overall survival (OS) between groups were analyzed. The results of univariate and multivariate analysis showed that CD34+ cell dose ＜5×106 /kg (P = 0.010) and the pre-transplant CRP ＞10 mg/L (P = 0.020) were independent risk factors for primary PGF after allo-HSCT. The primary PGF was an independent factor related to poor OS for patients with myeloid tumors (P = 0.046). In conclusion, monitoring the pre-transplant CRP and ensuring CD34+ cell dose ≥5×106 /kg in graft are effective measures to prevent the occurance of primary PGF after allo-HSCT. The occurance of primary PGF affects the overall survival of patients with myeloid tumors who underwent allo-HSCT and we should do a good job in prevention and treatment of primary PGF at an early stage.
Prediction of cancer driver genes through integrated analysis of differentially expressed genes at the individual level
Authors: Gao Bo , Zhao Yue , Li Guojun 
Published: August 2022

Abstract
Driver mutations are anticipated to change the gene expression of their related or interacting partners, or cognate proteins. We introduce DEGdriver, a novel method that can discriminate between mutations in drivers and passengers by utilizing gene differential expression at the individual level. Tested on eleven TCGA cancer datasets, DEGdriver substantially outperforms cutting-edge approaches in distinguishing driver genes from passengers and exhibits robustness to varying parameters and protein-protein interaction networks. We further show, through enrichment analysis, that DEGdriver is capable of identifying functional modules or pathways in addition to novel driver genes.
Snare and rubber band combined assisted traction ： a novel method for endoscopic submucosal dissection in treating early gastric cancer
Authors: bai Bing , Li Zhen , Mao Chongshan , Kuang Shengli , Zhou Bingxi 
Published: August 2022

Abstract
Background: Endoscopic submucosal dissection（ESD）has the advantages of high complete resection rate, less trauma and higher safety than open surgery. However, ESD has high technical requirements and is difficult to operate, especially when submucosal dissection fails to fully expose the submucosa. To create a good operational field of vision and achieve accurate cutting, a variety of endoscopic assisted traction methods have emerged. Our study team has invented a new traction method, that is, snare combined with rubber band assisted ESD in the treatment of early gastric cancer.Methods: Retrospective study was performed in 35 patients diagnosed as having early gastric cancer and received ESD assisted by snare and rubber band method from January 2016 to December 2018.The en bloc excision rate, procedure time, complication rate were analyzed. Results: All lesions received en bloc resection. The lesion size ranged ２～6ｃｍ.The median procedure time was 30min (ranging 25～45min). There was no bleeding or perforation occurred during and after the procedure.Conclusion: Snare-rubber band assisted traction method can provide good vision during the ESD procedure for early gastric cancer, and increase resection efficiency, reduce the operation time and complication rate.
Schooling, Migration and Social Violence in Colombia
Authors: Rodriguez Jhon James Mora , Cuandros-Menaca Andres 
Published: August 2022

Abstract
The article discusses the relationship between migration and schooling in social violence context. Migration stimulates the development and alleviates poverty by providing capital for household human capital investments in the migrant’s home country. However, in the context of social violence, the positive effects of migration may be offset or disappear entirely. Our findings suggest that living in a migrant household increases both the probability of reaching non-compulsory levels of education and the likelihood of completing high school. However, we show that exposure to social violence can mitigate the positive impact of migration on schooling disappears for children in unsafe (violent) neighborhoods.[1]JEL Codes: O15, F22, I25
Environmental impacts of large-scale Spirulina (Arthrospira platensis) production in Hellisheidi geothermal park Iceland: life cycle assessment
Authors: Tzachor Asaf , Smidt-Jensen Asger , Ramel Alfons , Geirsdóttir Margrét 
Published: August 2022

Abstract
Spirulina algae (Spirulina platensis) cultivated in geothermally powered photobioreactors is here proposed as a potentially resource efficient, zero-carbon, and nutritious alternative to conventional beef meat. Employing a standard life cycle assessment, environmental impacts of large-scale Spirulina production in this facility are calculated. The production facility is sited in Orka náttúrunnar (ON Power) Geothermal Park, Iceland, and benefits from resource streams accessible through Hellisheiði (Hellisheidi) power station, including renewable electricity for illumination and power usage, hot- and cold-water streams for thermal management, freshwater for cultivation, as well as CO2 for biofixation. During cultivation, GHG-intensive ammonia-based fertilizers are replaced with macronutrients sourced from natural open mines. LCA results show that production of 1 kg of wet edible biomass in this facility requires 0.0378 m2 non-arable land, 8.36 m3 fresh water, and is carbon neutral with − 0.008 CO2-eq GHG emissions (net zero). Compared with conventionally produced meat from beef cattle, Spirulina algae cultured in the ON Power Geothermal Park, referred to in this study as GeoSpirulina, requires less than 1% land and water, and emits less than 1% GHGs. Considering food and nutritional security concerns, cultivation in a controlled environment agriculture system assures consistent nutritional profile year-round. Moreover, GeoSpirulina biomass assessed in this study contains all essential amino acids as well as essential vitamins and minerals. While keeping a balanced nutrition, for every kg beef meat replaced with one kg GeoSpirulina, the average consumer can save ~ 100 kg CO2-eq GHGs. It is concluded that environmental impacts of GeoSpirulina production in the Hellisheidi facility are considerably lower than those of conventionally produced ruminants.
Coumarin-derived imino sulfonate 5h ameliorates cardiac injury induced by myocardial infarction via activating Sirt1/Nrf2 signaling pathway
Authors: Xu Xueli , Shi Yangyang , Yu Qingwen , Peng Yajie , Zhao Fei , Cui Jing , Chen Yajing , Liu Lingxu , Zhang Yiran , Zhang Ji , Wei Bo 
Published: August 2022

Abstract
Myocardial infarction (MI) is an irreversible damage caused by ischemia and hypoxia in coronary arteries accompanied with elevated levels of catecholamine, leading to the accumulation of free radicals. Our previous study discovered coumarin-derived imino sulfonates as a novel class of potential cardioprotective agents possessing strong anti-oxidative effect in cardimyocytes. Therefore, the identification of the compound with the highest cardioprotective activity, 5h, and the mechanism involved was necessary. As a kind of catecholamine, isoproterenol can clinically induce myocardial infarction injury similar to the symptoms of myocardial infarction patients. Our experiments explored the underlying mechanism of this effect of compound 5h by assessing cardiac function, infarct size, histopathological changes, and downregulation of Sirt1 by transfection of adenovirus in vitro and by administering Ex527, a specific inhibitor of Sirt1, in vivo. Compound 5h exhibited strong cardioprotective actions in vivo and in vitro via improving cell survival, cardiac function and decreasing the cellular oxidative stress and cardiac infarct size against MI. Furthermore, compound 5h significantly enhanced cardiac expression of Sirt1, subsequently activating the Nrf2/NQO1 signaling pathway. However, adenovirus induced Sirt1 downregulation or Sirt1 specific inhibitor largely blocked such beneficial effects of 5h in vitro and in vivo, respectively. Taken together our results demonstrated, for the first time, that the cardioprotective action of 5h against MI was mediated by reducing oxidative stress and apoptosis through the Sirt1/Nrf2 signaling pathway. Our findings proposed novel insights in the development and evaluation of coumarin-derived imino sulfonate compounds as epigenetics-targeted drug therapy for MI.
Thermal Physiology integrated species distribution model predicts profound habitat fragmentation for estuarine fish with ocean warming
Authors: Harishchandra Akila , Xue Huijie , Salinas Santiago , Jayasundara Nishad 
Published: August 2022

AbstractSpecies distribution models predict a poleward migration for marine ectotherms with ocean warming. However, a key limitation in current species distribution models (SDM) is that they do not account for population-specific heterogeneity in physiological responses to temperature change resulting from local adaptations and acclimatization. To address this gap, we developed a novel, Physiology Integrated BioClimate Model (PIBCM) that combines habitat-specific metabolic thermal physiological tolerance of a species into a bioclimate envelope model. Using a downscaling approach, we also established a fine-resolution coastal sea-surface temperature data set for 2050–2080, that showed a high degree of location-specific variability in future thermal regimes. Combining predicted temperature data with the PIBCM model, we estimated habitat distribution for a highly eurythermal intertidal minnow, the Atlantic killifish (Fundulus heteroclitus), a species that likely presents a best-case-scenario for coastal vertebrates. We show that the killifish northern boundary shifts southwards, while distinct habitat fragmentation occurs in the southern sub-population (due to migration of adjacent fish populations to the nearest metabolically optimal thermal habitat). When compared to current SDMs (e.g., AquaMaps), our results emphasize the need for thermal physiology integrated range shift models and indicate that habitat fragmentation for coastal fishes may reshape nursery habitats for many commercially and ecologically important species.
Point-of-collection testing for screening of psychoactive substances among drivers of Kerala, India
Authors: M.S. Siva Prasad , C.V. Priyatha , Jayesh K Joseph , E.M. Aneesh 
Published: August 2022

Abstract
One of the important risk factors for road traffic crashes is driving under the influence of drugs (DUID). This study aimed to check the prevalence of drugs of abuse (DOA) among the goods carriage drivers associated with the southern state of India, Kerala. Roadside point-of-collection testing (POCT) of oral fluid collected from the participants on the major highways was done using the Evidence MultiSTAT DOA Oral Fluid II Assay kits and the Evidence MultiSTAT analyzer. Out of the total samples (n= 249), 53 (21.29%) were positive for one or more DOA. A high prevalence of tetrahydrocannabinol (THC) (10.04%) and synthetic cannabinoids were detected in the samples. The use of ketamine, alpha-PVP, LSD, methamphetamine, opiate, 6-MAM, benzodiazepines I, methadone, PCP, tramadol, and amphetamine were also detected in oral fluid samples and their frequency of use was ranging between 4.02-0.80%. Confirmatory analysis using ultra-high performance liquid chromatography-tandem mass spectrometry showed excellent agreement with the results of the screening test. This was the first qualitative study conducted among drivers in India for the detection of DOA. Scientific studies are crucial for assessing the effectiveness of strategies for reducing psychoactive substance use by drivers before or while driving.
Hadronic Interaction Model Dependence in Cosmic Gamma-ray Flux Estimation Using an Extensive Air Shower Array with a Muon Detector
Authors: Okukawa Sousuke , Katayose Yusaku , Anzorena Marcos , Asano Shunta , Condori Cesar , Fuente Eduardo , Gomi Asuka , Hibino Kinya , Hotta Naoki , Jimenez-Meza Ana , Kato Chihiro , Kato Sei , Kawashima Teruyoshi , Kawata Kazumasa , Koi Tatsumi , Kojima Hiroshi , Kurashige Daichi , Lozoya Jorge , Mayta Rosa , Miranda Pedro , Munakata Kazuoki , Nagaya Kaito , Nakamura Yoshiaki , Nakazawa Yuuki , Nina Carlos , Nishizawa Masaki , Ogio Shoichi , Ohnishi Munehiro , Oshima Akitoshi , Raljevich Mirko , Rivera Hugo , Saito Toshiharu , Sakakibara Yohei , Sako Takashi , Sako Takashi K. , Shibata Shoichi , Shiomi Atsushi , Subieta Martin , Tajima Norio , Takano Wakiko , Takita Masato , Tameda Yuichiro , Tanaka Koichi , Ticona Rolando , Toledano-Juarez Ivan , Tsuchiya Harufumi , Tsunesada Yoshiki , Udo Shigeharu , Yamazaki Katsuya , Yokoe Yoshichika 
Published: August 2022

Abstract
Observation techniques of high-energy gamma rays using air showers have remarkably progressed via
the Tibet AS$\gamma$, HAWC, and LHAASO experiments.
These observations have significantly contributed to gamma-ray astronomy in the northern sky's sub-Peta electron volts (PeV) region.
Moreover, in the southern sky,
the ALPACA experiment is underway at 4,740\,m altitude on the Chacaltaya plateau in Bolivia.
This experiment estimates the gamma-ray flux from the difference between the number of on-source and off-source events by real data, utilizing the gamma-ray detection efficiency calculated through Monte Carlo simulations, which in turn depends on the hadronic interaction models.
Even though the number of cosmic-ray background events can be experimentally estimated, this model dependence affects the estimation of gamma-ray detection efficiency.
However, previous reports have assumed that the model dependence is
negligible and have not included it in the error of gamma-ray flux estimation.
Using ALPAQUITA, the prototype experiment of ALPACA, we quantitatively evaluated the model dependence on hadronic interaction models for the first time.
We evaluate the model dependence on hadronic interactions as less than 3.6\,\% in the typical gamma-ray flux estimation performed by ALPAQUITA; this is negligible compared with other uncertainties such as energy scale uncertainty in the energy range from 6 to 300 TeV, which is dominated by the Monte Carlo statistics.
This upper limit of 3.6\,\% model dependence is expected to apply to ALPACA.
Predictors of Return to Sports at 6 Months After Anterior Cruciate Ligament Reconstruction in Non-elite Athletes
Authors: Zhou Lan , Xu Yihong , Guo Luqi , Zhang Jing , Zhou Tianping Zhou , Wang Siya , Wang Shaobai , Xu Weidong 
Published: August 2022

Abstract
Introduction:
The return to sports (RTS) is a primary goal after anterior cruciate ligament reconstruction (ACLR) for most elite and non-elite athletes. The predictors and kinematic factors associated with the RTS are unclear. This study aimed to explore the predictors of RTS and the difference of knee kinematics between the RTS and non-RTS (nRTS) group in non-elite athletes.
Methods
This study was conducted with 41 non-elite athletes who underwent ACLR. The isokinetic test, single and triple hop tests, three-dimensional knee kinematics and the administration of two questionnaires [International Knee Documentation Committee (IKDC) and ACL-Return to Sport after Injury scale (ACL-RSI)] were conducted 6months after surgery. One year post-operatively, an interview and Tegner score were used to assign patients to RTS and nRTS groups. Multivariate logistic regression and receiver operating characteristic curve analyses were performed to identify the independent predictors of the RTS.
Results
Thirty (73%) patients were allocated to the RTS group and 11 (27%) were allocated to the nRTS group. Multivariate logistic regression showed that significant predictors of RTS (odds ratio/10-unit increase, P, cut-off value, sensitivity, specificity) were the single hop LSI (1.714, P = 0.004; 84.4%, 0.867, 0.818), IKDC (1.486, P = 0.015; 84.5, 0.867, 0.727), ACL-RSI (1.262, P = 0.016; 53.8, 0.833, 0.818) and quadriceps LSI (1.137, P = 0.012; 90.4%, 0.700, 0.818). Compared with the uninvolved limbs, the involved limbs in the nRTS group had larger external rotation angles at initial contact (IC; P = 0.019) and maximum (P < 0.001), smaller flexion angle at IC (P = 0.01) and greater anteroposterior translation (P = 0.05) in stance phase. In the RTS group, only the flexion-extension range of motion differed significantly between limbs (P < 0.001).
Conclusions
Single hop test LSI, IKDC score, ACL-RSI score and quadricep strength at 6 months after ACLR were related to a greater likelihood of nRTS at 1 year after surgery in non-elite athletes. The nRTS group also displayed more asymmetrical gait behavior.
Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity
Authors: Choi Hwajung , Yang Liu , Liu Yudong , Jeong Ju-Kyung , Cho Eui-Sic 
Published: August 2022

Abstract
Tooth roots embedded in the alveolar bone do not typically undergo resorption while the bone continues remodeling in its physiological state. In this study, we analyzed genetically modified mice with the functional inactivation of nucleotide pyrophosphatase 1 (Npp1), encoded by ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1). This mutation leads to the formation of ectopic cervical cementum vulnerable to external tooth root resorption. Cementoblasts with the inactivation of Enpp1 extensively expressed non-collagenous matrix proteins enriched with bone sialoprotein (Bsp), dentin matrix protein 1 (Dmp1), and osteopontin (Opn), which have roles in mineralization through nucleation and in cell adhesion through the Arg-Gly-Asp (RGD) motif. In cementoblasts with the inactivation of Enpp1, β-catenin was significantly activated and induced the expression of these non-collagenous matrix proteins. In addition, adenosine triphosphate (ATP), which is the most preferred substrate of Npp1, accumulated extracellularly and autocrinally induced the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cementoblasts with inactivated Npp1. Consequently, these results strongly suggest that functional Npp1 preserves thin and less-mineralized cementum integrity and supports the anti-resorptive properties of tooth roots through ATP homeostasis in the physiological state of cervical cementum.