bluuebunny/crossref_metadata_2025_split huggingface dataset:
A historical review of aggregation‐induced emission from 2001 to 2020: A bibliometric analysis
Authors: Xia Qiming , Zhang Yiyin , Li Yiling , Li Yirun , Li Yixuan , Feng Zhe , Fan Xiaoxiao , Qian Jun , Lin Hui 
Published: January 2022

AbstractAggregation‐induced emission (AIE) is a photophysical phenomenon that a certain group of luminescent materials that become highly luminous when aggregated in a bad solvent or solid state. This year is the 20th anniversary since the AIE concept firstly proposed in 2001. Many advanced applications were gradually being explored, covering optics, electronics, energy, and bioscience and so on. At present, bibliometrics can enlighten the researchers with comprehensive sights of the achievements and trends of a specific field, which is critical for academic investigations. Herein, we presented a general bibliometric overview of AIE covering 20 years of evolution. With the assistance of Web of Science Core Collection database and several bibliometric software tools, the annual publication and citation, most influential countries/regions, most contributing authors, journals and institutions, second near‐infrared (NIR‐II) related hotspots, as well as the forecast of frontiers were demonstrated and systematically analyzed. This study summarizes the current research status in AIE research field and provides a reference for future research directions.
The insertion site is the main risk factor for central venous catheter‐related complications in patients with hematologic malignancies
Authors: Heidenreich Daniela , Hansen Eleonore , Kreil Sebastian , Nolte Florian , Jawhar Mohamad , Hecht Anna , Hofmann Wolf‐Karsten , Klein Stefan A. 
Published: January 2022

AbstractCentral venous catheters (CVC) placed either via the internal jugular vein (IJV) or the subclavian vein (SCV) are routinely used in patients with hematologic malignancies. In this retrospective study, we systematically compared CVC‐associated complications for both insertion sites, IJV and SCV. Between January 2011 and June 2013, all consecutive patients (n = 87) were included with at least one CVC (n = 153; n = 94 IJV; n = 59 SCV) at our institution due to induction/consolidation for AML/ALL or autologous hematopoietic cell transplantation (HCT). Primary study endpoints were central line‐associated (CLABSI), catheter‐related (CRBSI) blood stream infections and local inflammation (LI) at the insertion site. CRBSI occurred earlier and more frequently in the IJV‐ versus the SCV‐group with an incidence rate of CRBSI at day 15 of 10% versus 0% (p = .04) and a rate of CRBSI per 1000 CVC days of 5.7 versus 1.2. In addition, CLABSI was detected more often in IJV‐ compared to SCV‐CVC (26% vs. 8%, p = .009). Conversely, LI occurred more frequently and earlier in SCV‐ versus IJV‐CVC (88% vs. 56%, p < .0001) with a median time to LI of 9 versus 14 days (p < .0001). The strongest risk factor for the endpoints CRBSI, CLABSI, and LI was the insertion site. However, SCV insertion was a risk factor for LI (p = .001, HR: 2.0), insertion in the IJV a risk factor for CLABSI (p = .044, HR: 2.7) and CRBSI (p = .036, HR: 5.4). These results demonstrate a differential effect of the insertion site of CVC in neutropenic patients with a significantly reduced frequency of CVC‐related blood stream infections in SCV‐CVC.
Pd(II)‐Catalyzed Selective Amination of Inert γ‐C(sp3)−O Bonds of Aliphatic Amides with Hydrazines
Authors: Chen Sai , Lin Cong , Xu Yiqing , Liu Xiuhong , Shen Liang 
Published: January 2022

AbstractThe first palladium‐catalyzed selective amination of inert methyl and methylene γ‐C(sp3)−O bonds of aliphatic amides with hydrazines by using the strategy of 8‐aminoquinoline‐directed C(sp3)−H activation/β‐O elimination/hydrofunctionalization is reported. This method features a broad scope of hydrazines, affording an efficient and simple method for the synthesis of corresponding γ‐hydrazine substituted carboxylic acid derivatives that are commonly seen in drug molecules and other bioactive compounds.
Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets
Authors: Nuytemans Karen , Lipkin Vasquez Marina , Wang Liyong , Van Booven Derek , Griswold Antony J. , Rajabli Farid , Celis Katrina , Oron Oded , Hofmann Natalia , Rolati Sophie , Garcia‐Serje Catherine , Zhang Shanshan , Jin Fulai , Argenziano Mariana , Grant Struan F.A. , Chesi Alessandra , Brown Christopher D. , Young Juan I. , Dykxhoorn Derek M. , Pericak‐Vance Margaret A. , Vance Jeffery M. 
Published: January 2022

AbstractWe previously demonstrated that in Alzheimer's disease (AD) patients, European apolipoprotein E (APOE) ε4 carriers express significantly more APOE ε4 in their brains than African AD carriers. We examined single nucleotide polymorphisms near APOE with significant frequency differences between African and European/Japanese APOE ε4 haplotypes that could contribute to this difference in expression through regulation. Two enhancer massively parallel reporter assay (MPRA) approaches were performed, supplemented with single fragment reporter assays. We used Capture C analyses to support interactions with the APOE promoter. Introns within TOMM40 showed increased enhancer activity in the European/Japanese versus African haplotypes in astrocytes and microglia. This region overlaps with APOE promoter interactions as assessed by Capture C analysis. Single variant analyses pinpoints rs2075650/rs157581, and rs59007384 as functionally different on these haplotypes. Identification of the mechanisms for differential regulatory function for APOE expression between African and European/Japanese haplotypes could lead to therapeutic targets for APOE ε4 carriers.
Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low‐to‐middle‐income country
Authors: Suemoto Claudia K. , Bertola Laiss , Grinberg Lea T. , Leite Renata E. P. , Rodriguez Roberta D. , Santana Pedro H. , Pasqualucci Carlos A. , Jacob‐Filho Wilson , Nitrini Ricardo 
Published: January 2022

AbstractIntroductionEducation, and less frequently occupation, has been associated with lower dementia risk in studies from high‐income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low‐middle‐income country sample.MethodsIn this cross‐sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR‐SOB). We investigated the association of occupation complexity and education with CDR‐SOB using adjusted linear regression models for age, sex, and neuropathological lesions.ResultsIn 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR‐SOB (1–4 years: = ‐0.99, 95% confidence interval [CI] = –1.85; –0.14, P = .02; ≥5 years: = –1.42, 95% CI = –2.47; –0.38, P = .008). Occupation complexity and demands were unrelated to cognition.DiscussionEducation, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults.
Modified nanocrystalline cellulose partially replaced carbon black to reinforce natural rubber composites
Authors: Jiang Weihui , Cheng Zhuohuang , Wang Jingjing , Gu Ju 
Published: January 2022

AbstractAs a renewable nanomaterials, nanocellulose was generally considered as a green filler for reinforcing polymer. In this study, nanocrystalline cellulose (NCC) isolated from softwood pulp was successfully modified, and the modified nanocrystalline cellulose (m‐NCC) was used to partially replace carbon black (CB) to reinforce natural rubber (NR). Then, the dispersion of m‐NCC in the rubber matrix and the mechanical properties of NR composites were studied. The results showed that the surface modification of NCC improved its dispersion in the NR matrix and the filler‐rubber interfacial interaction. In addition, the m‐NCC partly replaced the CB‐reinforced NR composite with a lower stress at 300% elongation, but the tensile strength, elongation at break, tear strength, and wear resistance of the composites were significantly improved. Besides, the dynamic compression fatigue heat built‐up of the composites in which m‐NCC partially replaced CB was increased, but DIN abrasion and the flex cracking resistance was improved. From these properties, it can be seen that the partial replacement of CB by NCC could basically approach or even achieve the effect of NR composites reinforced by CB, indicating that the NCC had good rubber reinforcement ability.
Fe II emission in active galactic nuclei
Authors: Gaskell Martin , Thakur Neha , Tian Betsy , Saravanan Anjana 
Published: January 2022

AbstractWe review problems raised by Fe II emission in active galactic nuclei (AGNs) and address the question of its relationship to other broad‐line region (BLR) lines. The self‐shielding, stratified, BLR model of Gaskell, Klimek & Nazarova (Astrophysics, 2007; GKN) predicts that Fe II emission comes from twice the radius of Hβ, in agreement with widths of lines of Fe II lines being only 70% of the widths of Hβ. This disagrees with some reverberation mapping results, which have suggested that Fe II and Hβ arise at similar radii. The highest quality reverberation mapping, however, supports the predictions that Fe II comes from twice the radius of Hβ. We suggest that lower quality reverberation mapping of Fe II is biased to give too small lags. We conclude that, in agreement with the GKN model, the region emitting Fe II is the outermost part of the BLR just inside the surrounding dust. The model naturally gives the Doppler broadening required by models of Fe II emission. Optical Fe II emission implies typical reddenings of . This helps to explain the ratio of UV to optical Fe II emission. Simulations show that the amplitude of Fe II variability is consistent with being the same as for Hβ variability. The Fe II/Hβ ratio is a good proxy for the Eddington ratio. The ratio might be driven in part by the strong soft X‐ray excess because the X‐rays destroy grains and release iron into the gas phase. We propose that the correlation of Fe II strength of radio and host galaxy properties is a result of AGN downsizing.
A State‐of‐the‐Art Update on Integrated CO2 Capture and Electrochemical Conversion Systems
Authors: Gutiérrez‐Sánchez Oriol , Bohlen Barbara , Daems Nick , Bulut Metin , Pant Deepak , Breugelmans Tom 
Published: January 2022

AbstractTo valorize waste CO2, capturing and utilizing it to produce chemical building blocks is currently receiving a lot of attention. In this respect, amine and alkali base solutions have shown to be efficient CO2 capturing solutions and electrochemical CO2 conversion is a promising technology to convert CO2 and, as such, reduce greenhouse gas emissions. However, to date, CO2 capture and utilization (CCU) technologies have been investigated almost exclusively as separate processes. This has the disadvantage that CO2 has to be desorbed and compressed from the capture solution before sending it to the CO2 electrolyzer, seriously increasing the capital and operational costs of the overall technology. To improve the valorization potential of the CCU technologies, integrating both technologies by directly utilizing the capture solution as an electrolyte for the electrochemical CO2 reduction (eCO2R) is a highly promising approach. This technology is however limited by low Faradaic efficiencies (FE) and partial current densities that can be achieved with these solutions. The main reason for this is the slow CO2 release rate at the catalytic interphase. Nevertheless, in recent years, in light of tackling these challenges, several studies successfully managed to decrease the costs of the CO2 capturing step and to electrochemically convert more efficiently the CO2 capture solutions. Herein, we review the status of the integrated CO2 capture and electrochemical conversion technology, discussing the recent developments and advances both in the field of CO2 capture and eCO2R.
Novel Electrode Materials and Redox‐Active Electrolyte for High‐Performance Supercapacitor
Authors: Zhang Pei , Mu Jiahui , Kong Xiangjin , Wang Xiaowen , Ing Wong Shao , Sunarso Jaka , Xing Wei , Zhou Jin , Zhao Yi , Zhuo Shuping 
Published: January 2022

AbstractHeteroatom doping has been increasingly applied to enhance the electrochemical performance of carbon materials when used as supercapacitor electrodes. However, the use of doped electrode by itself often does not provide sufficiently high performance for aqueous‐based supercapacitor. Here, a high‐performance supercapacitor was developed, using nitrogen‐doped microporous carbon spheres‐based materials and a redox‐active electrolyte as electrodes and electrolyte, respectively. The doped electrode, which was produced via template and self‐assembly routes, exhibited a well‐developed microporous structure, large specific surface area, and abundant heteroatoms. The combination of the heteroatom‐doped electrode and KI‐H2SO4 electrolyte in supercapacitor substantially increased the specific capacitance, from 230 F g−1 to 532 mAh g−1. Such a large enhancement was attributed to the addition of KI as a redox mediator in the aqueous electrolyte. The NCS‐800 supercapacitor has a specific capacity as high as 68 mAh g−1 (at a 1 A g−1 current density) in KI‐H2SO4 electrolyte. It could retain 57 % of capacitance even after maintaining a constant voltage of 1 V for 5 hours, highlighting its good electrochemical performance of NCS‐800 as a supercapacitor electrode material.
A generalized linear secant bulk modulus based correlation for the prediction of compressed liquid density
Authors: Ramos‐Pallares Francisco 
Published: January 2022

AbstractA generalized correlation for the prediction of compressed liquid density has been developed based on the linear secant bulk modulus (LSM) concept. The correlation was developed using a dataset containing over 25 000 density data points from non‐polar and polar components collected from the literature. The LSM correlation fitted the data in this dataset with an overall average absolute deviation of 6 kg/m3. The developed correlation applies to pure components at reduced temperatures up to 0.99 and pressures up to 1 × 106 kPa and requires the following inputs: critical properties, acentric factor, saturated liquid density, and saturation pressure. The developed LSM correlation was tested on predicting the density of 18 components (over 23 000 data points) from assorted chemical families, including alcohols. The overall average absolute deviation was 5 kg/m3. For comparison, the Chang–Zhao correlation predicted the densities in the same Test Dataset with an overall average absolute deviation of 6 kg/m3. However, at pressures above 1 × 105 kPa, the LSM correlation predicted more accurate densities with an overall average absolute deviation of 11 kg/m3, whereas the Chang–Zhao correlation predicted the densities with an overall average absolute deviation of 26 kg/m3.
Bubble size distribution and gas holdup in bubble columns employing non‐Newtonian liquids: A CFD study
Authors: Paul Meljin Madavana , Pakzad Leila 
Published: January 2022

AbstractThe hydrodynamics involved with the rise of air bubbles in shear‐thinning non‐Newtonian liquids in bubble columns was investigated using computational fluid dynamics (CFD). In bubble columns, the bubble size distribution (BSD) and gas holdup significantly affect the mass transfer rates and the reactor design. Consequently, the influence of superficial gas velocity, flow index, consistency index, sparger bubble size, and yield stress were analyzed on a local and global scale. The bubble sizes and the coalescence and breakage phenomena were incorporated using the homogeneous discrete method of the population balance model (PBM). The bubbles underwent coalescence during ascent and exhibited bimodal distribution. The radial homogeneity of the gas phase increased axially. Moreover, the zones of low liquid dynamic viscosity produced zones of a high gas holdup. Though the dual effect of viscosity on gas holdup was non‐existent, the gas holdup surged after 35.1 mPa s at the mid‐zone and remained constant thereafter. The noteworthy differences in simulation results put further emphasis upon the importance of sparger bubble size in CFD modelling. A decrease in the overall gas holdup and the axial air velocity with yield stress was observed. CFD simulation proved capable of providing results in reasonable agreement with experiments.
Association between cumulative blood pressure in early adulthood and right ventricular structure and function in middle age: The CARDIA study
Authors: Liu Shenrong , Liao Yanfen , Zhu Zongyuan , Wang Shushui , Li Yifan , Liang Dongpo , Xie Yumei , Zhang Zhiwei 
Published: January 2022

AbstractObjectiveCumulative blood pressure (BP) exposure is a known risk factor for cardiovascular disease. This study sought to investigate the association between cumulative BP from early adulthood to middle age and right ventricular (RV) structure and function in middle age.MethodsWe included 2844 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults). Cumulative BP over the 30‐years follow‐up was defined as the sum of the product of mean BP for each pair of consecutive examinations and the time interval between these two consecutive examinations in years. RV structure and function were assessed by echocardiography. The main analyses utilized logistic and linear regression models.ResultsIn fully adjusted models, higher cumulative systolic BP was independently associated with lower tricuspid annular plane systolic excursion (TAPSE), right ventricular peak systolic velocity (RVS′), right ventricular early diastolic velocity (RVe′), and higher pulmonary arterial systolic pressure. Higher cumulative diastolic BP was independently associated with smaller RV basal diameter, lower TAPSE, RVS′, and RVe′. For categorical analyses of RV dysfunction, cumulative systolic BP was not related to systolic dysfunction. Per 1‐SD increase in cumulative systolic BP was associated with a higher risk of diastolic dysfunction, while an increase in cumulative diastolic BP was associated with a higher risk of systolic dysfunction and diastolic dysfunction.ConclusionsCumulative exposure to increased BP from early adulthood to middle age was associated with incipient RV systolic and diastolic dysfunction in middle age. Exposure to higher diastolic BP levels from early adulthood to middle age was associated with a smaller RV basal diameter in middle age.
Novel Insights and Perspectives for the Diagnosis and Treatment of Hearing Loss through the Implementation of Magnetic Nanotheranostics
Authors: Martín María Julia , Spitzmaul Guillermo , Lassalle Verónica 
Published: January 2022

AbstractHearing loss (HL) is a sensory disability that affects 5 % of the world‘s population. HL predominantly involves damage and death to the cochlear cells. Currently, there is no cure or specific medications for HL. Furthermore, the arrival of therapeutic molecules to the inner ear represents a challenge due to the limited blood supply to the sensory cells and the poor penetration of the blood‐cochlear barrier. Superparamagnetic iron oxide nanoparticles (SPIONs) perfectly coordinate with the requirements for controlled drug delivery along with magnetic resonance imaging (MRI) diagnostic and monitoring capabilities. Besides, they are suitable tools to be applied to HL, expecting to be more effective and non‐invasive. So far, the published literature only refers to some preclinical studies of SPIONs for HL management. This contribution aims to provide an integrated view of the best options and strategies that can be considered for future research punctually in the field of magnetic nanotechnology applied to HL.
Design, Synthesis, in vitro and in silico Characterization of 2‐Quinolone‐L‐alaninate‐1,2,3‐triazoles as Antimicrobial Agents
Authors: Moussaoui Oussama , Bhadane Rajendra , Sghyar Riham , Ilaš Janez , El Hadrami El Mestafa , Chakroune Said , Salo‐Ahen Outi M. H. 
Published: January 2022

AbstractDue to the ever‐increasing antimicrobial resistance there is an urgent need to continuously design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities of various heterocyclic compounds such as 2‐quinolone derivatives, we designed and synthesized new methyl‐(2‐oxo‐1,2‐dihydroquinolin‐4‐yl)‐L‐alaninate‐1,2,3‐triazole derivatives via 1,3‐dipolar cycloaddition reaction of 1‐propargyl‐2‐quinolone‐L‐alaninate with appropriate azide groups. The synthesized compounds were obtained in good yield ranging from 75 to 80 %. The chemical structures of these novel hybrid molecules were determined by spectroscopic methods and the antimicrobial activity of the compounds was investigated against both bacterial and fungal strains. The tested compounds showed significant antimicrobial activity and weak to moderate antifungal activity. Despite the evident similarity of the quinolone moiety of our compounds with fluoroquinolones, our compounds do not function by inhibiting DNA gyrase. Computational characterization of the compounds shows that they have attractive physicochemical and pharmacokinetic properties and could serve as templates for developing potential antimicrobial agents for clinical use.
Electrochemistry and Electrochromic Performance of a Metallopolymer Formed by Electropolymerization of a Fe(II) Complex with a Triphenylamine‐Hydrazone Ligand
Authors: Banasz Radosław , Kubicki Maciej , Wałęsa‐Chorab Monika 
Published: January 2022

AbstractThe complex of Fe(II) ions of general formula [FeL2](BF4)2 with triphenylamine‐hydrazone ligand L has been synthesized and characterized. Oxidative electropolymerization of the complex proceeded smoothly on the working electrode producing a homogenous thin film of metallopolymer. The film thickness and morphology of the layer was investigated by microscopy techniques such as scanning electron microscopy and atomic force microscopy, and the composition of the film was confirmed by X‐ray photoelectron spectroscopy analysis. It was found that fifty successive oxidation/reduction cycles resulted in a 120 nm thick film on the electrode surface. The metallopolymer was also characterized using cyclic voltammetry and spectroelectrochemical methods. The film was found to change its color from yellow to green‐blue, exhibit high change in transmittance of 60 % at 770 nm, and possess good electrochemical stability during 375 cycles of switching of the potential between −0.1 V and +1.5 V, owing to the presence of metal ions that link two ligand molecules resulting in formation of highly cross‐linked film. The switching times (coloration and bleaching) were calculated to be 34.2 s and 7.3 s, respectively. Coloration efficiency of the formed film of polymeric complex was found to be 144 cm2 C−1.