bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfil Epidemiológico da Mortalidade Materna no Município de Imperatriz-MA
Authors: Barcelos Simili Amanda , Sampaio Souza Aloiso , Araújo-Gomes Rafaela Cristina , Fontenele Moraes da Silva Lorrany , Fontoura Guilherme Martins Gomes , Bertolini Serafim de Carvalho Katerine , Zolinda Cantão Chaves Karlla 
Published: April 2022

O objetivo do estudo foi analisar o perfil dos óbitos maternos no município de Imperatriz, Maranhão, em um período de 10 anos, compreendendo os anos de 2008 a 2017. Caracteriza-se como um estudo descritivo, quantitativo e retrospectivo que avaliou variáveis sociodemográficas, dados clínicos e obstétricos das mulheres que foram à óbito materno, além das causas de morte. Prevaleceram entre as mortes maternas: mulheres de 30 a 39 anos; raça parda; com oito a 11 anos de escolaridade; com igual prevalência de gestantes com e sem companheiro; primigestas; donas de casa; que realizaram de quatro a seis consultas pré-natais; principalmente ocorrendo durante a gravidez, parto ou aborto; no hospital; tendo recebido assistência médica durante a doença que levou à morte; sendo a maioria por causas obstétricas diretas, com destaque para a pré-eclâmpsia e eclampsia. Os resultados mostraram que a mortalidade materna refletiu as falhas existentes no serviço de saúde pública, principalmente no que diz respeito à saúde da mulher. Este estudo poderá contribuir para a elaboração de políticas públicas e implantação de estratégias para reduzir o número de mortes maternas na cidade.

Palavras-chave: Mortalidade Materna. Obstetrícia. Saúde da Mulher.

Abstract
This study aim to analyze the profile of maternal deaths in the municipality of Imperatriz, Maranhão, over a period of 10 years, covering the years of 2008 to 2017. It is characterized as a descriptive, quantitative and retrospective study that evaluated sociodemographic variables, clinical and obstetric data of women who died of maternal death, in addition to the causes of death. Prevailed among maternal deaths: women aged 30 to 39; brown race; with eight to 11 years of schooling; with equal prevalence of pregnant women with and without a partner; primiparous; Housewives; who performed four to six prenatal consultations; mainly occurring during pregnancy, childbirth or abortion; no hospital; having received medical assistance during an illness that led to death; most of them due to direct obstetric causes, with emphasis on pre-eclampsia and eclampsia. The results induced that mortality reflected maternal as existing failures in the public health service, mainly with regard to women's health. This study can contribute to the preparation of public policies and the implementation of a reduction to reduce the number of maternal deaths in the city.

Keywords: Maternal Mortality. Obstetrics. Women's Health.
Études De Lithostabilisation De La Latérite Avec La Dolérite De Mansadala (Sud-Est Du Sénégal) Pour Une Utilisation En Couche De Base De Chaussée
Authors: Massamba Ndiaye , Jean-Pierre Magnan , Lamine Cissé 
Published: April 2022

Les sols latéritiques actuellement rencontrés sur le territoire sénégalais répondent mal aux exigences de qualité fixées par les règles de 2015 de l’Agence des Travaux et de Gestion des Routes du Sénégal (AGEROUTE-Sénégal) pour leur emploi en couche de base routière. Pour les utiliser dans cette couche, un traitement est nécessaire dans la plupart des chantiers courants au Sénégal.
Cet article étudie le comportement de ces matériaux latéritiques modifiés par traitement mécanique ou lithostabilisation par ajout de concassé de dolérite en provenance de Mansadala au sud-est du Sénégal. L’ajout de 20 % ou 25 % de ce matériau très peu utilisé en technique routière au Sénégal semble permettre l’utilisation du graveleux latéritique étudié en couche de base.
The lateritic soils currently encountered on Senegalese territory meet very little the quality requirements set by the 2015 rules of the Senegalese Road Works and Management Agency (AGEROUTE-Senegal) for their use as a road base layer. To use them in this layer, a treatment is necessary in most of the current construction sites in Senegal.
This article studies the behaviour of these lateritic materials, modified by mechanical treatment or lithostabilization by adding crushed dolerite from Mansadala in southern Senegal. The addition of 20% or 25% of this very little used material in road engineering in Senegal seems to make it possible to use the lateritic gravel studied as a base layer.
Impact des facteurs éducatifs sur la croissance économique régionale au Maroc : Une approche par l’économétrie spatiale
Authors: Eradi Ahmed , Moflih Youssef 
Published: April 2022

Ce papier examine les effets des facteurs éducatifs sur la croissance économique durant la période 2015-2019 dans les 12 régions marocaines. Pour ce faire, L’analyse des interactions spatiales se fait à travers le calcul des indices de Moran et LISA, ainsi, les approches d’économétrie spatiale SAR et SEM semblent être appropriés pour étudier l’effet de l’investissement public en matière de l’éducation sur la croissance économique en prenant en considération les retombées spatiales. Les résultats des interactions spatiales ont montré la persistance de l’état défavorable des régions vulnérables en termes du revenu, de financement et du rendement de l’éducation. L’investissement en capital a un effet plus positif et supérieur aux effets de l’investissement en matière de l’éducation et de la population active. L’investissement pourrait jouer un rôle plus important et contribue significativement dans la croissance économique des régions marocaines. Quelques politiques susceptibles de renforcer l'éducation et ses effets sur la croissance régionale sont proposés.

This paper examines the effects of educational factors on economic growth during the period 2015-2019 in the 12 Moroccan regions. In this framework, the analysis of spatial interactions is done through the calculation of Moran and LISA indices, thus, SAR and SEM spatial econometric models seem to be appropriate to study the impact of education on economic growth by considering spatial spillovers. The results of the spatial interactions showed the persistence of the unfavorable state of vulnerable regions in terms of income, financing and returns to education. Capital investment has a more positive and greater effect than the effects of education investment and labor force and thus investment could play a more important role in regional economic growth. Some policies that could enhance education and its effects on regional growth are proposed.
Model Pengembangan Desain Ilustrasi Buku Cerita Temi Story Sebagai Media Pengenalan Hidup Sehat di TK Mentari Bontoa
Authors: Nur Dhaahiru Aliza Shafira 
Published: April 2022

Pengenalan hidup sehat adalah kebiasaan yang perlu diperhatikan setiap individu. Maka dari itu perlu diperkenalkan sejak dini agar kebiasaan pola hidup sehat dapat menjadi kebiasaan baik yang melekat disetiap individu. Penelitian ini bertujuan untuk: (a) menghasilkan buku cerita bergambar sebagai media pengenalan hidup sehat, (b) mengetahui kelayakan buku cerita bergambar sebagai media pengenalan hidup sehat, (c) mengetahui efektivitas buku cerita bergambar sebagai media pengenalan hidup sehat. Jenis penelitian ini merupakan penelitian dan pengembangan (R&D) denganmengadaptasi model Borg dan Gall. Tahapan pengembangan meliputi lima tahapan: analisis kebutuhan, perencanaan, pengembangan produk awal, pengujian terbatas, revisi hasil uji produk. Analisis kebutuhan dilakukan dalam penelitian ini untuk mengetahui apaka buku cerita bergambar sebagai media pengenalan hidup sehat dibutuhkan. Berdasarkan tujuh responden menjawab sangat butuh dengan presentase 100%. Buku cerita Temi Story diuji validasi dan efektivitas. Hasil validasi oleh ahli media di peroleh 100% sangat baik. Hasil uji efektivitas diperoleh 75% layak dan 25% sangat layak.
The Role of OIC to Tackle Discrimination against Uighur Muslims by the Chinese Government in Xinjiang
Authors: Dalillah Nurul Indah 
Published: April 2022

Abstract
The Uighur are a minority Muslim group living in Xinjiang, China. Muslim Uighurs are prohibited from performing religious rituals in mosques and praying by the Chinese government. Human rights violations committed against Uighur Muslims such as being prohibited in freedom of expression, barriers to education, and discrimination against Uighur still occur in Xinjiang, China. Therefore, this paper will analyze the efforts of the Organization of Islamic Cooperation (OIC) as an organization that assists in resolving conflicts in Muslim countries and liberating Muslim rights to contribute to the prevention, management, and resolution of world conflicts that can make their efforts to free discrimination among Muslim Uighur. In this study the researcher using the theory of the role of international organizations from several experts. At the same time in this study using a qualitative method with a descriptive approach through books, journals, or news related to Uighur Muslim issues. The type of data collected also uses secondary data from several studies that have been conducted. The OIC has coordinated and dialogued with the Chinese government through a meeting of the OIC Secretariat General with the delegate of China to report the OIC's direct visit to Xinjiang but this has not freed Uighur Muslims.
Keywords: Discrimination, OIC, Uighur Muslim
Effects of Rotifer Feeding Frequency on Growth and Survival Rate of Early Larval Stages of Mud Crab, Scylla olivacea
Authors: Pattirane Chrisoetanto P. , Pattiasina Bethsy J. , Sangkia Frederik Dony 
Published: April 2022

Crustacean larvae have the characteristics of living as carnivorous organisms. This has an impact on the length of gut evacuation time which affects the feeding pattern of the larvae. The feeding strategy of mud crab larvae is modulated by the length of gut evacuation time. Another factor that can be subject to modulation is the frequency of feeding. This research aimed to evaluate rotifer frequency feeding of early larvae stages of mud crab, Scylla olivacea. This research was conducted at the Mariculture Fisheries Center, Ambon with an indoor system. This research began with carrying out parental maintenance to produce larvae. Larvae are fed with rotifers with different frequencies. The treatments were the frequency of feeding rotifers, namely: Treatment 1 (F1) was the frequency of 1x a day (9:00 am); Treatment 2 (F2) was a frequency of 2x a day (9:00 am & 13:00 pm) and Treatment 3 (F3) was a frequency of 3x a day (9:00am, 13:00pm & 17:00pm). Each treatment was given 3 replications. Based on the results of this study, it showed that feeding with a frequency of three times a day (F3 treatment) was able to have a positive effect on the survival rate of zoea larvae which on the third day was 58% and the fourth day was 22% higher than the F1 and F2 treatments. The growth of larvae showed that F3 treatment was higher than F1 and F2 on the sixth day with an increase in the absolute value of growth of 0.12044 mm compared to F1 of 0.05531 mm and F2 of 0.03253 mm. Keywords: frequency of feeding, growth, larvae, survival rate, mud crab
Phylogenetic relationships of sleeper gobies (Eleotridae: Gobiiformes: Gobioidei), with comments on the position of the miniature genus Microphilypnus
Authors: Macate Isadola Eusébio , Bessa-Silva Adam , Caires Rodrigo , Vallinoto Marcelo , Giarrizzo Tommaso , Angulo Arturo , Ruiz-Campos Gorgonio , Sampaio Iracilda , Guimarães-Costa Aurycéia 
Published: April 2022

Abstract
Microphilypnus and Leptophilypnion are miniaturized genera within the family Eleotridae. The evolutionary relationships among these taxa are still poorly understood, and molecular analyses are restricted to mitochondrial genes, which have not been conclusive. We compiled both mitochondrial and nuclear genes in order to study the phylogenetic position of Microphilypnus and the evolutionary history and relationships of eleotrids. We propose that Microphilypnus and Leptophilypnus (a non-miniature genus) are not sister groups as suggested by previous studies, but rather separate lineages that arose in the early Eocene, with Leptophilypnus recovered as a sister group to the other analyzed eleotrids. In fact, Microphilypnus is currently associated with the Neotropical clade Guavina/Dormitator/Gobiomorus. We also identified a well-supported clade that indicated Gobiomorus and Hemieleotris as paraphyletic groups, besides a close relationship among Calumia godeffroyi, Bunaka gyrinoides, Eleotris and Erotelis species. This is the first comprehensive report about the evolutionary relationships in members of the family Eleotridae, including multiloci and multispecies approaches. Therefore, we provided new insights about the phylogenetic position of some taxa absent in previous studies, such as the miniature genus Microphilypnus and a recently described species of Eleotris from South America.
Fyn interrupts telomere maintenance in stem cells by phosphorylating menin at tyrosine 603
Authors: PAUL SOUREN , McCourt Preston , Le Le Thi My , Ryu Joohyun , Czaja Wioletta , Bode Ann , Contreras-Galindo Rafael , Dong zigang 
Published: April 2022

Abstract
Telomeres protect chromosome ends and determine the proliferative potential of cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core components of telomerase are well defined, many aspects of telomerase regulation are poorly understood. We report a novel role for the Src family kinase Fyn, which interrupts telomere maintenance in stem cells by negatively regulating telomerase assembly. We determine that Fyn promotes SUMOylation of the scaffold protein menin at lysine 609 (K609) by phosphorylating menin at tyrosine 603 (Y603). We show that K609-SUMOylated menin associates with much greater affinity to the telomerase RNA component (TERC) and interferes with telomerase assembly by preventing dyskerin (DKC1) and H/ACA ribonucleoprotein complex subunit 1 (GAR1) from binding to TERC. Importantly, we find that inhibition of Fyn reduces telomere shortening in human iPSCs and mice harboring mutations for dyskeratosis congenita.
A Student-led Interprofessional Virtual Outreach Program for People with HIV during the Covid-19 Pandemic: A pilot program at an academic medical center in Boston
Authors: Solomon Daniel A. , Larrabee Susan , Ellis Joshua , Erfani Parsa , Johnson Shawn F. , Rich Katherine M. , Sandoval Raquel Sofia , Osman Nora Y. 
Published: April 2022

Abstract
Background: The Coronavirus disease 2019 (Covid-19) pandemic caused an abrupt disruption in clinical care and medical education, putting patients at increased risk for social stressors and displacing medical students from traditional clerkships. The pandemic also exposed the need for virtual tools to supplement clinical care, and an opportunity to create meaningful roles for learners. Methods: An interdisciplinary group designed a student-led virtual outreach program for patients with HIV whose care was limited by the pandemic. Patients were identified by clinicians and social workers using a clinic-based registry. Students called patients to conduct needs assessments, Covid-19 education, and to facilitate connection to services. Students participated in case-based didactics and workshops on motivational interviewing and patient engagement using virtual tools. Facilitated team meetings were held weekly during which themes of calls were identified.Results: During a three-month period, six students participated in the outreach program. 216 patients were identified for outreach calls, of which 174 (75.9%) were successfully reached by telephone. Rate of completed phone call did not differ by age. 60 patients had a preferred language other than English of which 95.6% were reached in their preferred language. Conclusions: Virtual proactive outreach can be used as a tool to support patients and engage students in clinical care when access to in-person care is limited. This model of care could be adapted to other ambulatory practices and integrated into pre-clerkship curriculum as an introduction to the social history and structural drivers of health (SDOH). (242/350)
Epidemiological analysis of age and spatial differences of HIV prevalence over the last decade in Nanjing, China
Authors: Zhu Zheng-ping , Xu Yuan-yuan , Li Xin , Ma Tao , Wu Su-shu , Shi Hong-jie , Qiao Meng-kai , Xu Wen-jiong , Ding Jie 
Published: April 2022

Abstract
ObjectiveTo describe the epidemiological characteristics of PLHIV, and to assess age and spatial distribution of HIV prevalence over the last decade in Nanjing.MethodsWe downloaded information of the reported PLHIV from Chinese HIV/AIDS comprehensive prevention system, and we performed descriptive, one-way ANOVA, autocorrelation analysis, spatial scanning and mapping of spatial distribution.Results5269 PLHIV that fulfilled the inclusion and exclusion criteria were included to our study. The HIV prevalence for each year rose from 1.09/10000 in 2011 to 5.70/10000 in 2020. The dominate transmission was sexual route. Homosexual transmission showed an upward trend from 61.5–74.5%, and decreased slowly to 62.9%, the proportion of drug injection transmission decreased from 10.6–0.2%. The characteristics of transmission routes, disease stage and the diagnosis way were different among three age groups, and the difference were statistically significant with all P<0.001. The spatial autocorrelation analysis showed that the spatial clustering of HIV prevalence existed among three age groups in 2016 and 2020. By the end of 2020, HIV prevalence clustering districts among Youth were Qinhuai, Gulou, Xuanwu, Qixia, Jiangbeinewarea. HIV prevalence clustering districts among Middle-aged were Qinhuai, Gulou, Xuanwu, Jianye, Yuhuatai, HIV prevalence clustering districts among Elderly were Qinhuai, Gulou, Xuanwu, Qixia.ConclusionThe steadily increasing HIV prevalence rate, the late diagnosis of Elderly, the expansion of the clustering districts among Youth, and the key clustering districts like Qinhuai and Gulou where risk factors exist all posed challenges to the prevention and control of HIV in Nanjing. Societal and medical resources should be deployed to deal with HIV epidemic under the consideration of the variation of age and geographic regions.
Exploring Robust Architectures for Deep Artificial Neural Networks
Authors: Waqas Asim , Rasool Ghulam , Farooq Hamza , Bouaynaya Nidhal 
Published: April 2022

Abstract
The architectures of deep artificial neural networks (DANNs) are routinely studied to improve their predictive performance. However, the relationship between the architecture of a DANN and its robustness to noise and adversarial attacks is less explored. We investigate how the robustness of DANNs relates to their underlying graph architectures or structures. This study: (1) starts by exploring the design space of architectures of DANNs using graph-theoretic robustness measures; (2) transforms the graphs to DANN architectures to train/validate/test on various image classification tasks; (3) explores the relationship between the robustness of trained DANNs against noise and adversarial attacks and the robustness of their underlying architectures estimated via graph-theoretic measures. We show that the topological entropy and Olivier-Ricci curvature of the underlying graphs can quantify the robustness performance of DANNs. The said relationship is stronger for complex tasks and large DANNs. Our work will allow autoML and neural architecture search community to explore design spaces of robust and accurate DANNs.
Cost Effectiveness Analysis of Home-Based Phototherapy Versus Hospital-Based Phototherapy for Treatment of Neonatal Hyperbilirubinemia in shiraz, Iran
Authors: Kavosi Zahra , Mozafari Malallah , Rezaee Mehdi , Keshavarz Khosro 
Published: April 2022

Abstract
Background
Neonatal jaundice is the most common cause of hospitalization of mature and healthy infants. Phototherapy is the most common treatment for the rise in indirect bilirubin. Hospitalization of infants has complications such as hospital infections, separation of the mother from the baby, occupying hospital beds and high cost of hospitalization. Since phototherapy is possible at home and by home care centers, this study was conducted to analyze the cost-effectiveness of phototherapy at home versus phototherapy in hospital in Shiraz in 2021.
Methods
This research is a complete economic evaluation of cost-effectiveness that was conducted cross-sectionally from March to August 2021 in Hafez and Hazrat Zeinab hospitals and Parseh and Ava Gostar home care centers in Shiraz. The study population included all neonates who were admitted to these centers with a diagnosis of jaundice for phototherapy. 180 neonates with jaundice in the two groups of hospital and home care were included in the study. The effectiveness index for this study was the average daily decrease in total bilirubin. We made use of cost and effectiveness forms to collect the required information. The results were presented in the form of incremental cost-effectiveness ratio (ICER) and one-way and probabilistic sensitivity analysis was used to measure the strength of the study results. TreeAge pro2020, Excel 2019 and Spss18 were used to analyze the collected data.
Results
The results showed that the average cost of phototherapy at home and hospital were $ 196.52 and $ 397.85, respectively, and the average effectiveness was 0.39 and 0.36, respectively. Therefore, according to the results, phototherapy at home is more cost-effective than phototherapy in the hospital. In addition, the results of one-way and probabilistic sensitivity analysis showed the strength of the research results.
Conclusion
Phototherapy at home is a more cost-effective option than phototherapy in the hospital. Therefore, it can be suggested to insurance organizations as well as service providers to prioritize phototherapy at home to be included in the basic insurance package.
Evaluation of additional gastrectomy after noncurative endoscopic submucosal dissection for early gastric cancer
Authors: Makimoto Shinichiro , Mushiake Yutaka , Takami Tomoya , Shintani Hiroshi , Kataoka Naoki , Yamaguchi Tomoyuki , Oura Shoji 
Published: April 2022

Abstract
BackgroundPerforming additional surgery after noncurative endoscopic submucosal dissection (ESD) for early gastric cancer is controversial. Our aims are to clarify the risk factors for lymph node metastasis (LNM) and local residual cancer (RC) after noncurative ESD and to determine recommendations for additional treatment. MethodsOf the 1483 patients who underwent ESD for early gastric cancer between January 2012 and April 2020, we retrospectively analyzed 151 patients diagnosed as having a lesion not meeting the curative criteria after ESD. Of these patients, 100 underwent additional gastrectomy, and 51 were observed without surgery. ResultsSurgical specimens showed LNM in 14 patients (14.0 %) and local RC in 7 (7.0 %). However, 81 patients (81.0 %) had neither of these malignancies. Multivariate analysis revealed that a positive lymphatic invasion (P = 0.035)　and an undifferentiated type (P = 0.047) were independent risk factors for LNM, whereas a positive horizontal margin (P = 0.017) was an independent risk factor for local RC. In the additional gastrectomy group, 3 patients (3.0 %) had recurrences, and 2 (2.0 %) died of gastric cancer. In the observation group, 1 patient (2.0 %) had distant recurrence, and 2 patients (3.9 %) had local recurrences.ConclusionFollowing noncurative ESD for early gastric cancer, we recommend an additional gastrectomy with lymph node dissection for patients with lymphovascular invasion and/or undifferentiated type. Careful follow-ups without additional surgery may be acceptable for patients with advanced age, severe comorbidity, or no lymphovascular invasion.