bluuebunny/crossref_metadata_2025_split huggingface dataset:
A SOD1-dependent mitotic DNA damage checkpoint
Authors: Gatenby Rachel , Li Nan , Lata Priya , Walne Thomas , Tufail Afzaal , Breitweiser Alexander , Thompson Ruth 
Published: October 2022

AbstractIn the event of DNA damage, the cell cycle can be slowed or halted to allow for DNA repair. The mechanisms by which this occurs are well-characterised in interphase, although the mechanisms underpinning mitosis slowing in response to damage are unclear. Canonical checkpoints and DNA repair pathways are largely repressed in mitosis, and whilst there is some level of mitotic DNA synthesis and repair, the bulk of DNA damage is processed for post-mitotic repair. How the decision is made between mitotic DNA repair and post-mitotic DNA repair is not known. We have identified the antioxidant enzyme Superoxide Dismutase 1 (SOD1) as an essential factor mediating delayed mitotic progression in response to DNA damage and replication stress. Cells depleted of SOD1 no longer exhibit DNA damage dependent mitotic delay, and display increased levels of damaged centromeres and mitotic defects. Whilst reactive oxygen species (ROS)-inducing agents also lead to SOD1-dependent mitotic delay, intracellular ROS levels do not correlate with mitotic arrest. SOD1 appears to play an important role in DNA repair in interphase and is recruited to the nucleus in response to DNA damage. In addition to control of mitotic progression in response to genotoxic stress, SOD1 also plays a major role in mitotic DNA synthesis. SOD- depleted cells show reduced levels of mitotic EdU incorporation in response to either replication stress or DNA breaks, seemingly in tandem with Rad51 andSOD1-depletion induced mitotic progression in the presence of DNA breaks is Rad52-dependent. We suggest that there are two responses to DNA breaks in mitosis; either arrest and mitotic repair or progression and post-mitotic repair; and these two pathways exist in a fine balance, controlled by a signaling cascade involving SOD1.
Reinforcement learning control for a flapping-wing micro aerial vehicle with output constraint
Authors: Huang Haifeng , Wu Xiaoyang , Wang Tingting , Sun Yongbin , Fu Qiang 
Published: October 2022

Purpose
This paper aims to study the application of reinforcement learning (RL) in the control of an output-constrained flapping-wing micro aerial vehicle (FWMAV) with system uncertainty.

Design/methodology/approach
A six-degrees-of-freedom hummingbird model is used without consideration of the inertial effects of the wings. A RL algorithm based on actor–critic framework is applied, which consists of an actor network with unknown policy gradient and a critic network with unknown value function. Considering the good performance of neural network (NN) in fitting nonlinearity and its optimum characteristics, an actor–critic NN optimization algorithm is designed, in which the actor and critic NNs are used to generate a policy and approximate the cost functions, respectively. In addition, to ensure the safe and stable flight of the FWMAV, a barrier Lyapunov function is used to make the flight states constrained in predefined regions. Based on the Lyapunov stability theory, the stability of the system is analyzed, and finally, the feasibility of RL in the control of a FWMAV is verified through simulation.

Findings
The proposed RL control scheme works well in ensuring the trajectory tracking of the FWMAV in the presence of output constraint and system uncertainty.

Originality/value
A novel RL algorithm based on actor–critic framework is applied to the control of a FWMAV with system uncertainty. For the stable and safe flight of the FWMAV, the output constraint problem is considered and solved by barrier Lyapunov function-based control.
Interorganisational citizenship behaviours: development and validation of a measurement scale in South African craft breweries
Authors: Brits Emmica , Czakon Wojciech , Volschenk Jako , Kraus Sascha 
Published: October 2022

PurposeCitizenship behaviours are used in organisation studies to explain their effectiveness and to capture the role of unsolicited, extra-role behaviours. Recent extensions towards the interorganisational context provide evidence that Interorganisational Citizenship Behaviours (ICBs) are important in facilitating supply chain operations and cluster innovation activities. This study took stock of citizenship behaviours literature within and among organisations, in order to develop and validate a measurement scale for ICBs useful in the food industry and beyond.Design/methodology/approachDeparting from a literature driven 10-dimensional construct, Th authors proceeded with validating our scale in the South African craft brewing industry. The authors ran a face validation, followed by confirmatory and exploratory factor analyses on a sample of 108 expert informants. The authors ran nomological tests through correlation and regression analysis. Finally, logical analysis was done to ensure the theoretical integrity of the mathematical indications.FindingsThe authors found support that the model consisting of interorganisational magnanimity, interorganisational advancement and interorganisational constructiveness, is relevant for value creation within coopetitive networks. The purified scale included three psychometrically distinct ICBs dimensions, measured by 31 items.Practical implicationsManagers can benefit from adequately identifying ICB in their environment, and among their competitors in particular. The study’s measurement scale offers a useful tool for an initial monitoring of firms in their competitive environment.Originality/valueThe authors extended and advanced prior research on the ICB construct by providing a rigorously validated, parsimonious measurement scale of ICBs. The authors bridged the ICB and coopetition literature to better understand spontaneous extra-role coopetitive network facilitating behaviours.
Measuring the perceptual, physiological and environmental factors that impact stress in the construction industry
Authors: Newton Sidney 
Published: October 2022

Purpose
The purpose of this study is to highlight and demonstrate how the study of stress and related responses in construction can best be measured and benchmarked effectively.

Design/methodology/approach
A range of perceptual and physiological measures are obtained across different time periods and during different activities in a fieldwork setting. Differences in the empirical results are analysed and implications for future studies of stress discussed.

Findings
The results of this study strongly support the use of multiple psychometrics and biosensors whenever biometrics are included in the study of stress. Perceptual, physiological and environmental factors are all shown to act in concert to impact stress. Strong conclusions on the potential drivers of stress should then only be considered when consistent results apply across multiple metrics, time periods and activities.

Research limitations/implications
Stress is an incredibly complex condition. This study demonstrates why many current applications of biosensors to study stress in construction are not up to the task and provides empirical evidence on how future studies can be significantly improved.

Originality/value
To the best of the author’s knowledge, this is the first study to focus explicitly on demonstrating the need for multiple research instruments and settings when studying stress or related conditions in construction.
Feasible versus desirable market offerings: the role of choice set size
Authors: Thai Nguyen T. , Yuksel Ulku 
Published: October 2022

Purpose
This paper aims to find out what product features become salient when consumers are exposed to many market offerings, demonstrating how choice set size influences construal mindset, which then affects the type of product consumers choose.

Design/methodology/approach
Experiment 1 provides preliminary evidence that being exposed to a large (vs small) choice set may drive people to focus more on the feasibility (i.e. a secondary feature) of a product and less on the desirability (i.e. a primary feature) when making a choice. Experiment 2 unveils the serial mediating roles of construal level and importance of price/design.

Findings
Consumers are more likely to select feasible (i.e. affordable) market offerings and not desirable (i.e. well-designed) ones when choosing from a large (vs small) choice set. This effect is serially mediated by mental construals and by the importance of price or design. Choosing from a large (vs small) choice set leads to low-level mental construals, which increase the importance of price (a feasibility attribute) while decreasing the importance of design (a desirability attribute), resulting in choice of feasible (affordable) market offerings over well-designed ones.

Research limitations/implications
Although consumers generally focus on the desirability of a choice or an action, choosing from large choice sets makes them focus more on the feasibility of market offerings because of low-level mental construals.

Practical implications
In today’s era of e-commerce, as consumers are exposed to too many product offerings, retailers should emphasize the feasibility of their market offerings (e.g. affordability) to increase the chance that consumers purchase their products. This research shows that people rely very much on product price to make selections when provided with a large choice set.

Originality/value
To the best of the authors’ knowledge, this research is the first to show that large choice sets make consumers choose affordable products over well-designed ones and introduces the serial mediation effect of construal level and importance of price/design. Accordingly, this research establishes that large choice sets activate low-level mental construals, which associate with a feasibility mindset that ultimately makes consumers choose an affordable product instead of a well-designed one. It adds to the literature on choice overload by showing that the importance of price overshadows the importance of design (aesthetics) when people are exposed to large choice sets.
Coffee and gastronomy: a potential ‘marriage’? The case of Vietnam
Authors: Vu Oanh Thi Kim , Duarte Alonso Abel , Martens Wil , Do Lan , Tran Luong Ngoc , Tran Thanh Duc , Nguyen Trung Thanh 
Published: October 2022

Purpose
The purpose of this study is to gain a more nuanced understanding of the relationship between a national product (coffee) and gastronomy. Moreover, incorporating the resource-based view of the firm framework, the importance of coffee is examined, as is the extent and potential to “marry” coffee and gastronomy into a tourism activity, and the need to develop such potential.

Design/methodology/approach
Semi-structured, face-to-face and online interviews were used to gather the viewpoints of 79 chefs and coffee shop owners/managers operating in Vietnam, the world’s second-largest coffee producer and home to a vibrant coffee shop industry.

Findings
The selected inductive analysis identified 11 dimensions, including “coffee infrastructure”, “coffee-based innovation”, “coffee-trigger” and “coffee resources”, emerged. These dimensions reveal a strong potential for a coffee and local gastronomy “marriage”. Furthermore, nine of the 11 dimensions provide direct guidance concerning the importance, the potential for “marriage”, coffee tourism development and what is needed to fulfil this potential.

Practical implications
The study affords understanding of Vietnam’s coffee industry, in particular its resources, and how these can be leveraged to combine with the nation’s gastronomy and produce more fulfilling food and beverage experiences.

Originality/value
Gastronomy, hospitality and tourism represent a well-defined partnership that can result in memorable consumer experiences. While the strength of this partnership is recognised, little is known about the potential to “marry” a national product such as coffee and local gastronomy. The study breaks new ground in this area and concludes with various theoretical and practical implications that contribute to more understanding of the coffee–gastronomy relationship.
The dynamics of entrepreneurial networking logics: evidence from United Kingdom high-tech start-ups
Authors: Jin Zhang Joanne , Baden-Fuller Charles , Zhang Jing 
Published: October 2022

PurposeThis study aims to explore how entrepreneurial firms' networking logics may change under different types of perceived uncertainty. The arrival of new knowledge from the entrepreneurial firm's network may alter the perceived technology and market uncertainty that in turn determines how the firm adopts or combines the two opposing logics of causation and effectuation. Focusing on the roles of external advisors recruited by the firms, the study probes the details of the cyclical process and the mechanism through which networking logics are altered.Design/methodology/approachIn this study the authors conducted a 3-year longitudinal multiple case study of 12 United Kingdom (UK) high-tech start-ups from prefounding to A-round funding with 54 semistructured interviews and meeting observations.FindingsThe knowledge of external advisors with distinct experience often reshapes the entrepreneurial firm's perceptions of uncertainty, leading to logics change in network development. The authors identify two types of knowledge brought by external advisors and discover how these can influence three networking logic pathways under different levels of technology and market uncertainty.Originality/valueThe study is one of the first to map the paths of changing logics along with different types of uncertainty in the context of entrepreneurial network development. The study unpacks one of the key mechanisms of networking logic changes: the knowledge and expertise of those advisors recruited by the entrepreneurial firms. The process model of changing logics contributes to the effectuation literature and entrepreneurial network research.
Financial fragility and financial stress during the COVID-19 crisis: evidence from Colombian households
Authors: Cardona-Montoya Raúl Armando , Cruz Vivian , Mongrut Samuel Arturo 
Published: October 2022

PurposeOur findings indicate that workers with more financial education were more prepared to face the negative effects on their finances from COVID. This ability reduces the probability of becoming financially fragile and experiencing financial stress.Design/methodology/approachThe authors applied a survey questionnaire to 856 Colombian adults and used principal component analysis to build an index for each factor. Then, the authors used a linear regression model with the indexes to test our hypotheses and verify our results using a structural equation model.FindingsOur findings indicate that workers who have more financial education are more prepared to face the negative effects on their finances, which reduces the probability of becoming financially fragile and having financial stress.Research limitations/implicationsThe authors found that there is no significant relationship between financial literacy and financial fragility, neither between financial literacy and financial stress, so a better financial education will not lower financial fragility and stress unless it is being applied by households through better financial preparedness.Practical implicationsIt is important to highlight that the pandemic not only taught us to improve biosecurity measures but also that financial strength, ability to work remotely and income diversification were key factors in facing this adverse shock, the authors show that high levels of financial education have a positively relationship with the ability of individuals to manage their resources, so private and public institutions have to promote better financial education.Originality/valueThis is the first study that applies the four different indexes to an emerging country (i.e. Colombia), and the first one to create and use a financial stress index.
Countering cybercrimes as the strategy of enhancing sustainable digital economy in Nigeria
Authors: Sule Babayo , Sambo Usman , Yusuf Muhammad 
Published: October 2022

Purpose
This study aims to examine the threats posed by cybercrimes toward the quest for achieving a reliable digital economy and to identify practical strategies for countering the crime.

Design/methodology/approach
A qualitative phenomenological paradigm was used as the methodology. Both primary and secondary sources were consulted for data collection. A thematic analytical interpretation was used for data analysis.

Findings
This study discovered that Nigeria is a leverage environment for using digital economy as a means of diversifying the economy owing to population bulge, and an increase patronage of internet and digital space but the threats of cyberfraudsters is ostracising a substantial number from using it which is decreasing the performance of the digital economy.

Research limitations/implications
The research is limited by the scarcity of resources to widen the horizon of the study particularly the fieldwork and the rampant incidences of cybercrime in Nigeria which poses a difficult task for studying the phenomenon. In addition, this study is constrained by the confidentiality in releasing data owing to the sensitivity of the subject of study and its relationship to national security.

Practical implications
This study presents some suggestions that are plausible in countering the crimes and enhancing the digital economy in Nigeria through effective surveillance, massive information and communication technology (ICT) awareness creation for users and severe penitent sanctions for cybercriminals will help in securing digital spaces.

Social implications
This study has social implications including the suggestion for simplifying digital transactions that will save time, increases economic activities and passive multiple stream income for Nigerians and ease of doing business with less risk of robbery and other cumbersome tasks.

Originality/value
This study has originality value because after the survey of the existing literature, a field work is conducted to have the views of experts on the subject of study which adds value to the subject and originality of the findings.
Open for antiracism: supporting educators to use open education for antiracist teaching
Authors: Daly Una T. , Glapa-Grossklag James , Nguyen Alyssa , Valenzuela Ireri 
Published: October 2022

Purpose
The Open for Antiracism program supports faculty to change their teaching practices to be antiracist through the affordances of open educational resources (OER) and open pedagogy. This study aims to raise questions about how professional development impacts student outcomes, and how faculty perceive the utility of OER and open pedagogy to support antiracist teaching and learning.

Design/methodology/approach
An evaluation plan examined how faculty participants perceived the effectiveness of OER and open pedagogy to make their classes antiracist. Students compared their experiences in treated classes with those in other classes. Participating faculty completed pre- and post-surveys and a subset sat for interviews.

Findings
Faculty participants felt prepared to implement antiracist practices using OER and open pedagogy. Eighty-seven percent reported they were highly likely to recommend the program and 80% plan to continue using open pedagogy. Eighty percent of students reported they were more active or engaged than in other classes and that they examined biases of the discipline.

Originality/value
This study raises the question of how antiracist teaching approaches impact student outcomes over a longer term. Further, how can changes to teaching strategies impact institutions? Do teams of instructors offer support in ways that lead to a greater voice within an institution?
A tale of two pandemics: teachers’ disproportionate views on student engagement in remote learning
Authors: Wake Donna , Mills Michael 
Published: October 2022

PurposeThis study aims to use culturally responsive pedagogy as a model to examine teachers’ views of the equity implications found within virtual instruction.Design/methodology/approachThe researchers used a descriptive methods design based on survey research employing both fixed (quantitative) and open response (qualitative) options to curate teachers’ perceptions of their students’ abilities to engage in online learning.FindingsTeachers articulated anxiety for student engagement based on access as well as concerns for student engagement and social emotional learning (SEL) connection. Data point to disparate views of students’ abilities to engage in remote learning based on demographic markers. Teachers also noted their own limitations in providing engaging online instruction that was culturally responsive and included social emotional learning (SEL) learning.Originality/valueThis study provided a unique opportunity to explore teachers’ perceptions of their students in online learning contexts as well as teachers’ perceptions of their own abilities to support diverse students in remote learning. Teachers’ responses indicated deficit views of their culturally and linguistically diverse students and signaled awareness of their own limitations in providing online instruction that was culturally responsive and student centered. Study findings point to a need to equip teachers with tools to mitigate systemic inequity in online contexts.
Relationship between meteorin-like peptide (Metrnl) serum levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in type 2 diabetes patients
Authors: Khajebishak Yaser , Madani Sadra , Faghfouri Amir Hossein , Soleimani Ali , Ilaei Sara , Peyrovi Said , Payahoo Laleh 
Published: October 2022

Purpose
Meteorin like-peptide (Metrnl) modulates energy hemostasis and relieves inflammation and oxidative stress. This study aims to investigate the relationship between Metrnl levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in obese type 2 diabetic patients.

Design/methodology/approach
This analytical cross-sectional study was carried out between August 2020 and March 2021on 93 people (n = 32 obese type 2 diabetic patients, n = 31 healthy obese, n = 30 healthy normal weight). Serum Metrnl levels were measured by enzyme-linked immunosorbent assay. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde and total antioxidant capacity were measured using standard methods. Body composition was assessed by bioelectrical impedance analysis. p-Value less than 0.05 was considered significant.

Findings
Serum Metrnl levels were lower in obese diabetic patients than in healthy normal-weight subjects (82.5 [72.4–94.5] ng/mL compared to 154 [129–189] ng/mL). The difference in Metrnl levels between the two groups was significant (p < 0.001). The difference in Metrnl levels between the two groups was significant. Moreover, a significant correlation between Metrnl level and both TNF-a and hs-CRP was detected (p = 0.006 and p < 0.001, respectively) and the correlation between Metrnl and IL-6 was borderline (p = 0.051). A negative correlation was revealed between Metrnl level and anthropometric measurements and body composition (p < 0.05) with the exception of fat-free mass and skeletal muscle mass.

Originality/value
To discover sufficient evidence for the therapeutic function of Metrnl and its use as a prognostic biomarker in the management of type 2 diabetes mellitus, future clinical studies are needed to highlight other factors influencing Metrnl serum levels.