bluuebunny/crossref_metadata_2025_split huggingface dataset:
A COMPARATIVE STUDY OF EFFICACY ON GLYCEMIC CONTROL BY GLIMEPIRIDE VERSUS TENELIGLIPTIN AS AN ADD ON TO METFORMIN THERAPY IN TYPE 2 DIABETES MELLITUS PATIENTS
Authors: BOMMINENI SASHIDHAR REDDY , SHRAVANI P. , SHYAM J. , ALEKHYA M. , SRIKANTH B. 
Published: March 2022

Objective: In our study, the objective was to evaluate the effectiveness of glycemic control of Glimepiride versus Teneligliptin for 2nd-line therapy in combination with Metformin in T2DM patients.
Methods: A Randomized, Observational, Prospective study has been conducted in outpatient and inpatient departments of General Medicine in RVM Hospital (Laxmakkapally, Mulugu, Siddipet, Telangana). A total of 100 patients with T2DM were recruited in our study in which 50 patients were in Group A (Metformin-Glimepiride) and the other 50 patients were in Group B (Metformin-Teneligliptin). The comparative assessment of efficacy was conducted using glycemic parameters such as FBS, PPBG and HbA1c to interpret the results.
Results: The mean difference values of HbA1c pre-treatment and post-treatment of Group A were calculated as 1.47 and of Group B was 0.83. The mean difference values FBS pre-treatment and post-treatment of Group A were found to be 56.96 and Group B was 29.62. The PLBS mean difference at Pre-treatment and Post-treatment of Group A and Group B was obtained to be 115.8 and 52.58, respectively.
Conclusion: From the results obtained, we hereby conclude that, though there was no large difference between the lowering of HbA1c values by two Groups, the FBS and PLBS levels were diminished significantly by Group A (Metformin-Glimepiride) than Group B (Metformin Teneligliptin). Therefore, Glimepiride is considered to be more beneficial than Teneligliptin when combined with Metformin Monotherapy.
PROTECTIVE FEATURES OF LOBOPHORA VARIEGATA METHANOLIC EXTRACT (LVME) ON COGNITIVE BEHAVIOUR AND REDOX HOMEOSTASIS IN N-NITROSODIETHYLAMINE TREATED DROSOPHILA MELANOGASTER
Authors: AJITHA ADAIKKALM , SUBRAMANIAN PERUMAL 
Published: March 2022

Objective: The protecting influence of methanolic extract of seaweed (Lobophora variegata) on cognitive as well as biochemical indices in N-Nitrosodiethylamine (NDEA, a potent carcinogen) treated Drosophila melanogaster is evaluated.
Methods: In this study, Flies are divided into four groups; group 1–(control), group 2-flies were treated with 0.01% NDEA in food medium, group 3–with 0.01% NDEA and 0.01% Lobophora variegata methanolic extract (LVME) and group 4-with 0.01% LVME alone.
Results: Behavioural abnormalities (negative geotaxis, phototaxis, smell and taste chemotaxis, hygrotaxis and thermotaxis) were quantitatively deviated in NDEA treated flies compared to control but were tend to be normalized in LVME treated flies. The contents of protein carbonyl, thiobarbituric acid reactive substance (TBARS), protein thiol and lipid peroxides were noticeably augmented in NDEA treated flies than control flies and correspondingly tend to normalize in LVME treated groups. Further, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and reduced glutathione (GSH) were decreased in NDEA treated group and were significantly increased (p<0.05) in LVME treated groups.
Conclusion: It is well known that seaweed extracts contain numerous beneficial phytochemicals in abundantly. From our investigation, we found that the 0.01% LVME is efficient in reverting the abnormal behaviours and restoring the redox homeostasis of NDEA induced carcinogenesis in Drosophila melanogaster. Our investigation indicates that these phytochemicals could prevent the abnormalities in behaviour and redox homeostasis during carcinogenesis in D. melanogaster.
The assessment of the integrated safety of Russian oil and gas enterprises
Authors: Gvozdev E. V. 
Published: March 2022

Introduction. The article addresses the choice of a method used to analyze hierarchies and pairwise comparisons (hereinafter — MAH), that serve as a framework for an integrated corporate safety assessment methodology. Its application ensures the transformation of input information, obtained in the form of a characteristic description of an assessed event, into the resulting assessment that has a weighted numerical value.Goals and objectives. The main purpose of the article is to obtain an assessment result in respect of the actions that are added to industrial and fire safety checklists applied to assure the integrated safety of an enterprise. A selected MAH is used to make pairwise comparisons of factors and alternatives. Values of local and global priorities can be determined for each element under study. Weighted coefficients, obtained in the form of local priorities, are related to the activities being checked, while global priorities are directly related to the services (structural units) that ensure the sustainable integrated security of an enterprise.Methods. The authors provide a rationale for the choice of MAH, which allows itemizing the values demonstrating the intensity of influence of factors and break them down into components. At the stage of synthesizing the obtained analytical results with the help of MAH, the results obtained by expertise must be verified by determining the value of the expert consistency ratio to confirm the adequacy of the obtained result.Results. The probability of influence of analyzed hazards, related to accidents and fires at the enterprises under consideration, was assessed as a function of their causes during the 7-year period under review. The article presents calculated coefficients of communication, impacts and influence made by specialists employed with respective services (structural units) on the industrial and fire safety subsystems that encompassed the integra­ted safety of an enterprise. The results of introducing correction factor g, whose dependence is expressed by final indicators of damage measured in economic (ruble) and social (human) losses, are presented.Discussion. The article focuses on the fact that the sustainable operation of industrial enterprises depends on the reliability margin of integrated corporate safety, the maintenance of which requires particular resources (financial, material resources, as well as the time, needed for the personnel to eliminate any identified deviations, etc.). Given that the resources focused on the integrated safety assurance are limited, they cannot meet all requests made by the heads of services (departments), while highly risky targeted activities need more research.
The comparative evaluation of the criteria used to determine the critical values of the partial density of carbon monoxide as part of the calculation of time to the blocking of escape routes in case of a room fire
Authors: Puzach S. V. , Cherepanov R. A. , Akperov R. G. 
Published: March 2022

Introduction. Critical values of the partial density of gas, the toxic dose or relative mass of carboxyhemoglobin in human blood serve as the criteria determining the time to the blocking of escape routes due to the presence of carbon monoxide. However, the comparative analysis of the effect produced by the selected criterion on the time to the blocking of escape routes due to the presence of this gas has not been conducted yet.Goals and objectives. The purpose of the article is to compare the values of the time to the blocking of escape routes by carbon monoxide obtained using various methods of determining the critical values of the carbon monoxide density. Towards this end, experimental studies on combustion processes of various solid and liquid combustible substances and materials were conducted in a small-scale test unit, and calculations of the time to the blocking of escape routes with carbon monoxide were made on their basis.Theoretical fundamentals. The amount of carbon monoxide, inhaled during a fire, is calculated using experimentally measured partial densities of CO and mathematical models designated for the calculation of the toxic dose of this gas and formation of carboxyhemoglobin in human blood.Results and discussion. Experimental dependencies between the testing time and medium-volume densities of monoxide emitted during the combustion of the “low smoke” PVC cable sheathing, timber (pinewood), chocolate, transformer oil and vegetable oil are presented. The authors obtained theoretical dependencies between the toxic dose and mass concentration of carboxyhemoglobin in human blood, on the one hand, and the time for the combustible materials, analyzed in the article. It has been found that the values of time to the blocking of escape routes due to the presence of carbon monoxide may differ significantly depending on the method used to determine the critical values of the carbon monoxide density.Conclusions. Standard methods, used to calculate the time to the blocking of escape routes due to the presence of carbon monoxide, employ the value of the critical partial density which may involve a substantial overestimation of the above time frame and the underestimation of the toxic effect produced on a person in the process of his/her evacuation. Therefore, it is necessary to apply all methods, discussed in the article, to select the minimum value of the above time frame.
Evaluation of the bearing capacity of socket contacts within the framework of a fire investigation
Authors: Nedobitkov A. I. , Abdeyev B. M. 
Published: March 2022

Introduction. The data, provided in the article, demonstrate the relevance of the socket fire safety improvement in the course of operation. The purpose of the article is to develop a research-backed method of examining the socket contacts that feature high transient resistance or change in shape. The method can be subsequently used to identify causes of damages in a fire investigation.Materials and methods. A JSM-6390LV scanning electron microscope with a module designated for the energy dispersive microanalysis is used in the research. The subjects of research are type C (EU Type C) and type F (EU Type F) sockets. The failure surfaces of socket contacts were analyzed without preliminary sample preparation.Theoretical fundamentals (theory and calculations). A physical and mathematical model of the limit bearing capacity of socket contacts, similar to the real construction, has been developed. The model serves as the framework for a practical computational algorithm of the expert analysis of mechanical and geometrical characteristics. The solution is reduced to short calculation formulas, that can be used to evaluate the bearing capacity of so­cket contacts. The applicability of the developed mathematical model to fire investigations is proven in a specific ­example.Results and discussion. The authors analyze cases of socket fires, caused by the loss of the bearing capacity of socket contacts in the process of operation. Photos of the oxide film on the contact surface and its elemental composition are provided in the article. The experimental data have proven that the fusion of contacts and the presence of an oxide film, featuring high specific resistivity, are a significant criminalistic evidence that helps to identify causes of fire.Conclusions. The authors propose a method for the identification of the bearing capacity of socket contacts. The method can be used to determine if a subsequent fire is related to the socket ignition. The information, provided in the article, can be used by specialists in the course of an expert examination of socket contacts withdrawn from the site of the fire to identify the failure mechanisms and, ultimately, causes of fire.
Autoeficácia docente na educação inclusiva e características do contexto de ensino
Authors: Nina Karla , Ramos Edson Marcos Leal Soares , Ravagnani Luis Ricardo , Britto Gisele Maria Gomes , Pontes Fernando Augusto Ramos , Silva Simone Souza da Costa 
Published: March 2022

O objetivo deste estudo foi descrever a associação da autoeficácia de professores em práticas educacionais inclusivas com variáveis do contexto de ensino e características dos docentes. Participaram 193 professores da educação básica, sendo 77,72 % do sexo feminino e 22,28 % do sexo masculino de escolas particulares, confessionais e públicas estaduais localizadas nos municípios de Belém e Castanhal, Pará, Brasil. Foram aplicados os instrumentos de caracterização e a escala de eficácia de professores em práticas educacionais inclusivas. As técnicas de análise de dados foram a análise fatorial e a análise de correspondência. Dentre os resultados encontrados, verificaram-se as associações entre as variáveis investigadas, o que sugere que ao julgar a própria capacidade em práticas educacionais inclusivas, o professor considera alguns fatores presentes no contexto e em sua trajetória docente. Espera-se que este estudo possa contribuir com o estímulo a formação continuada de professores no contexto inclusivo.
Strategi pemasaran untuk meningkatkan tingkat hunian kamar di tengah pandemic covid-19 di alaya resort ubud
Authors: Saksiari Luh Made 
Published: March 2022

Tujuan penelitian ini adalah mengidentifikasi potensi lingkungan internal dan eksternal serta menganalisis strategi yang tepat yang akan digunakan untuk meningkatkan tingkat hunian kamar di tengah pandemi COVID-19. Penelitian ini menggunakan data kualitatif berupa Bauran Pemasaran 7P dan data kuantitatif berupa hasil kuisioner yang digunakan untuk menentukan analisis SWOT dan analisis Triangulasi. Data primer diperoleh dari hasil wawancara, pemberian bobot dan rating untuk faktor-faktor IFAS, EFAS, sedangkan data sekunder diperoleh dari data statistic seperti three months forecast, history and forecast, cancelation report Pandemic Covid-19. Teknik pengumpulan menggunakan wawancara, observarsi partisifatif, wawancara tidak terstuktur, studi dokumentasi, kuesioner. Hasil penelitian menghasilkan Strategi pemasaran alternatif yang dihasilkan dari kaudran SWOT adalah titik sumbu X (internal) 8,6 dengan sumbu Y (eksternal) 10,6, sehingga koordinat sumbu (x,y) berada pada titik kuadran I, yang artinya berada disituasi yang menguntungkan, dimana memiliki peluang dan kekuatan sehingga peluang pasar yang besar dapat dimanfaatkan secara optimal seperti memanfaatkan lokasi yang strategis, memanfaatkan café lokal yang berdampingan dengan hotel untuk sarana operasional seperti penyediaan breakfast, menambah daya tarik dengan menambahkan guest activity dan melakukan promosi mengenai kegiatan operasioal hotel selama pandemi dengan memanfaatkan teknologi digitalisasi untuk menarik tamu untuk berkunjung. Hasil analisa Triangulasi berdasarkan focus strategy serta hasil analisa kuadran SWOT menunjukkan perlu berfokus dalam memperbaharui website dengan promo-promo terbaru, melakukan promosi secara berkala melalui sosial media seperti instagram dan facebook, menambah benefit kepada tamu yang menginap, serta melakukan competitor analysis dengan menyesuaikan harga kompetitor dan memperbaharui publish rate supaya memiliki harga saing yang sesuai dengan kompetitronya.
Pendekatan Saintifik dengan Model Pembelajaran Berbasis Proyek (PjBL) untuk Meningkatkan Hasil Belajar Matematika Siswa Kelas V SD
Authors: Raini Gusti Kadek 
Published: March 2022

Guru di sekolah dasar dalam pembelajaran cenderung mengajarkan pada domain pengetahuan saja, penilain lebih banyak menggunakan tes, dan rapor cenderung hanya melaporkan kompetensi bidang pengetahuan. Hal ini dapat memengaruhi hasil belajar siswa menjadi rendah. Penelitian ini bertujuan untuk menganalisis pendekatan saintifik dengan Model Pembelajaran Berbasis Proyek (PjBL) untuk meningkatkan hasil belajar matematika siswa kelas V. Penelitian tindakan kelas ini terdiri atas dua siklus. Setiap siklus terdiri atas tahap rencana tindakan, pelaksanaan, observasi/evaluasi, dan refleksi. Subjek penelitian ini adalah siswa kelas V SD yang berjumlah 15 orang. Pengumpulan data dalam penelitian ini dilakukan dengan metode tes. Data dianalisis dengan teknik analisis statistik deskriptif. Hasil penelitian menunjukkan adanya peningkatan rata-rata hasil belajar matematika sebesar 8,67, dari 71,00 pada siklus I menjadi 79,67 pada siklus II. Jadi, dapat disimpulkan bahwa penerapan pendekatan saintifik dengan model pembelajaran berbasis proyek (PjBL) dapat meningkatkan hasil belajar matematika siswa kelas V SD. Implikasi penelitian ini diharapkan dapat membantu siswa dan guru pada proses pembelajaran sehingga dapat meningkatkan minat dan motivasi belajar serta hasil belajar menjadi lebih baik.
Model Pembelajaran Problem Based Learning Untuk Meningkatkan Hasil Belajar Kimia Pada Pokok Bahasan Termokimia
Authors: Antara I Pande Putu Alit 
Published: March 2022

Penelitian tindakan Kelas ini dilaksanakan di SMA Negeri 1 Semarapura di Kelas XI MIPA.4 Semester ganjil tahun pelajaran 2019/2020 yang kemampuan siswanya untuk pelajaran kimia cukup rendah. Tujuan penulisan penelitian tindakan kelas ini adalah untuk mengetahui apakah model pembelajaran problem based learning dapat meningkatkan hasil belajar kimia siswa. Metode pengumpulan datanya adalah tes hasil belajar. Metode analisis datanya adalah deskriptif baik untuk data kualitatif maupun untuk data kuantitatif. Hasil yang diperoleh dari penelitian ini adalah problem based learning dapat meningkatkan hasil belajar kimia siswa. Ini terbukti dari hasil yang diperoleh pada awalnya mencapai nilai rata-rata 76,54 dengan ketuntasan belajarnya 71,43%, pada siklus I mencapai nilai rata-rata 80,77 dengan ketuntasan belajarnya 88,57% dan pada siklus II mencapai nilai rata-rata 84,49 dengan ketuntasan belajarnya 100%. Kesimpulan yang diperoleh dari penelitian ini adalah model pembelajaran problem based learning dapat meningkatkan hasil belajar kimia pada pokok bahasan termokimia.
Contribution of the Leukocyte Adherence Inhibition Test for the Evaluation of Immunoreactivity against Gluten Extracts in Non—IgE-Mediated / Non-Autoimmune Gluten-Related Disorders
Authors: Olivier Celso Eduardo , Pinto Daiana G. , Teixeira Ana P. M. , Santana Jhéssica L. S. , Santos Raquel A. P. G. , Lima Regiane P. S. 
Published: March 2022

Background: The Non-Celiac Gluten Sensitivity (NCGS) is a category inside the Gluten-Related Disorders (GRD) that groups the patients with unidentified mechanisms responsible for their symptoms.
Objective: To evaluate the opportunity of an ex vivo challenge immunoassay, the Leukocyte Adherence Inhibition Test (LAIT), to discriminate non—IgE-mediated gluten-specific immunoreactivity in patients with NCGS.
Methods: Ex vivo challenge tests performed with gluten latex extract, monitored by LAIT, were assayed in an asymptomatic control group of 30 individuals and a group of 52 patients with GRD not related to any identifiable immune mechanism (NCGS).
Results: The mean Leukocyte Adherence Inhibition (LAI) of the control group was 10.9%. The mean LAI of the NCGS patients’ group was 54.9%. The non-parametric Wilcoxon-Mann-Whitney U test comparing the control group with the NCGS patient’s group showed significance with a p-value < 0.00001.
Conclusion: The LAIT is an ex vivo challenge test able to discriminate gluten-sensitive and gluten-tolerant individuals, suggesting the participation of an immune Non—IgE-mediated hypersensitivity reaction in patients with the clinical diagnosis of NCGS.
Suspected COVID-19 Cases Admitted in a Tertiary Care Hospital. Correlation of Demographic and Clinical Characteristics with Viral Load Results and Hospitalization
Authors: Mourtzikou Antonia , Korre Antonia , Stamouli Marilena , Seitopoulou Christina , Petraki Ioanna , Kalliora Georgia , Koumpouros Panagiotis , Karle Paraskevi , Kimouli Maria 
Published: March 2022

Background: The current pandemic outbreak of COVID-19 due to the SARS-CoV-2 virus affected the health care systems, health services and economy globally. It also affected the health of the population worldwide, with high mortality and morbidity rates. The present study aimed to study the patients that were admitted to a tertiary care hospital and to investigate the potential correlation between hospitalization and RT-PCR for SARS-CoV-2 results with demographic characteristics and clinical characteristics. Moreover, it aimed to examine a mathematical formula that might describe the correlation of the aforementioned parameters.
Methods: The study population included 1244 patients admitted to the Nikea General Hospital "Agios Panteleimon", Piraeus, Greece. Patient age, gender, underlying diseases, travel history, symptoms, etiology for hospital admission and contact with confirmed cases were recorded. Potential correlation of hospitalization and RT-PCR for SARS-CoV-2 results with the aforementioned characteristics were identified by chi-square test of independence and logistic regression analysis.
Results: We observed significant correlation of hospitalization with fever, cough, dyspnea, pneumonia, travel history and etiology for hospital admission. We observed significant correlation of RT-PCR for SARS-CoV-2 results with rapid antigen test result, hospitalization etiology for hospital admission and contact with confirmed COVI-19 case.
Conclusions: According to the logistic regression model, RT-PCR for SARS-CoV-2 result, fever, dyspnea, pneumonia, and underlying disease are the most important predictors for hospitalization in the population under study. Contact with confirmed COVID-19 case is the most important predictor for RT-PCR for SARS-CoV-2 result.
Karakteristik Fluida Mata Air Panas di Kabupaten Tanah Datar
Authors: Fajrin Muhammad , Putra Ardian 
Published: March 2022

Penelitian ini bertujuan untuk mengdentifikasi karakteristik fluida pada 6 (enam) titik mata air panas di Kabupaten Tanah Datar terkait asal usul fluida panas bumi, pengenceran fluida panas bumi dan kesetimbangan fluida panas bumi. Konsentrasi Li, B, Na, K, dan Mg pada masing-masing sampel diukur dengan menggunakan Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) dan konsentrasi Cl diukur menggunakan dengan metode titrasi. Diagram segitiga Cl-Li-B menunjukkan seluruh sampel didominasi oleh Cl yang mengindikasikan bahwa mata air panas di Kabupaten Tanah Datar berasal dari sumber panas bumi dan terjadi sedikit pengenceran batuan sedimen organik. Plot diagramÂ segitiga Na-K-Mg menunjukan seluruh sampel berada pada daerah immature water yang mengindikasikan fluida panas bumi Kabupaten Tanah Datar bercampur dengan air permukaan yang cukup banyak.Â This study aims to identify the characteristics of the fluids at 6 (six) hot springs in Tanah Datar Regency regarding the origin of geothermal fluids, dilution of geothermal fluids and equilibrium of geothermal fluids. The concentrations of Li, B, Na, K, and Mg in each sample were measured using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) and Cl concentrations were measured using the titration method. Based on these results, the Cl-Li-B triangle diagram shows that all samples are dominated by Cl, which indicates that the hot springs in Tanah Datar Regency originate from geothermal sources and there is a slight dilution of organic sedimentary rocks. The plot of the Na-K-Mg triangle diagram shows that all samples are in the immature water area, which indicates that the geothermal fluid in Tanah Datar is mixed with quite a lot of surface water.