bluuebunny/crossref_metadata_2025_split huggingface dataset:
GeFSIX‐1‐Cu based semi‐interpenetrating network mixed matrix membranes for efficient CO2 separation
Authors: Cheng Jun , Hou Wen , Liu Niu , Yang Chen , Zhou Junhu 
Published: July 2022

AbstractIn order to increase CO2 separation efficiency, semi‐interpenetrating network mixed matrix membranes (SIPN‐MMMs) were loaded with GeFSIX‐1‐Cu (Cu(4,4′‐bipyridine)2(GeF6)) and poly ethylene glycol dimethyl ether (PEGDME). Two long‐chain polymers poly ethylene glycol diacrylate (PEGDA) and poly ethylene glycol methyl ether acrylate (PEGMEA) jointly constituted a crosslinked PEO backbone, and CO2‐philic short‐chain polymer PEGDME and anion‐pillared hybrid porous materials GeFSIX‐1‐Cu were embedded into the backbone to introduce strong CO2 adsorption sites and provide extra pore channels. Increasing GeFSIX‐1‐Cu loading in SIPN‐MMMs initially improved CO2 permeability and CO2/N2, CO2/CH4, and CO2/H2 selectivity, because the porous structure of GeFSIX‐1‐Cu provides additional pore channels for gas transport. In addition, the strong binding affinity between GeF62− and CO2 leads to improved membrane selectivity. When GeFSIX‐1‐Cu loading increased above 3 wt%, both CO2 permeability and CO2/N2, CO2/CH4, and CO2/H2 selectivity decreased, due to agglomeration of excess GeFSIX‐1‐Cu loading in SIPN‐MMMs. The highest CO2 permeability of 786 Barrer and CO2/N2 ideal selectivity of 43 (at GeFSIX‐1‐Cu loading of 3 wt%) were 36% and 38% higher than those of pure SIPN membrane, respectively, resolving the trade‐off between permeability and selectivity, and surpassing the Robeson upper bound (2008).
Mycetoma by Actinomadura madurae in the central nervous system: Renal transplant receptor disease
Authors: Cerrillos‐Gutiérrez José Ignacio , Ramírez‐Flores Diana , Gutiérrez‐Govea Alfredo , Andrade‐Sierra Jorge , Medina‐Pérez Miguel , Rojas‐Campos Enrique 
Published: July 2022

AbstractThe mycetoma is a granulomatous chronic disease, subcutaneous disease is the common presentation, very few cases are reported affecting central nervous system, but there are not cases in Renal Transplant (RT).
Application of finite element analysis to tissue differentiation and bone remodelling approaches and their use in design optimization of orthopaedic implants: A review
Authors: Ghosh Rajdeep , Chanda Souptick , Chakraborty Debabrata 
Published: July 2022

AbstractPost‐operative bone growth and long‐term bone adaptation around the orthopaedic implants are simulated using the mechanoregulation based tissue‐differentiation and adaptive bone remodelling algorithms, respectively. The primary objective of these algorithms was to assess biomechanical feasibility and reliability of orthopaedic implants. This article aims to offer a comprehensive review of the developments in mathematical models of tissue‐differentiation and bone adaptation and their applications in studies involving design optimization of orthopaedic implants over three decades. Despite the different mechanoregulatory models developed, existing literature confirm that none of the models can be highly regarded or completely disregarded over each other. Not much development in mathematical formulations has been observed from the current state of knowledge due to the lack of in vivo studies involving clinically relevant animal models, which further retarded the development of such models to use in translational research at a fast pace. Future investigations involving artificial intelligence (AI), soft‐computing techniques and combined tissue‐differentiation and bone‐adaptation studies involving animal subjects for model verification are needed to formulate more sophisticated mathematical models to enhance the accuracy of pre‐clinical testing of orthopaedic implants.
Multiple introductions and overwintering shape the progressive invasion of Aedes albopictus beyond the Alps
Authors: Vavassori Laura , Honnen Ann‐Christin , Saarman Norah , Caccone Adalgisa , Müller Pie 
Published: July 2022

AbstractAedes albopictus originates from Southeast Asia and is considered one of the most invasive species globally. This mosquito is a nuisance and a disease vector of significant public health relevance. In Europe, Ae. albopictus is firmly established and widespread south of the Alps, a mountain range that forms a formidable biogeographic barrier to many organisms. Recent reports of Ae. albopictus north of the Alps raise questions of (1) the origins of its recent invasion, and (2) if this mosquito has established overwintering populations north of the Alps. To answer these questions, we analyzed population genomic data from >4000 genome‐wide SNPs obtained through double‐digest restriction site‐associated DNA sequencing. We collected SNP data from specimens from six sites in Switzerland, north and south of the Alps, and analyzed them together with specimens from other 33 European sites, five from the Americas, and five from its Asian native range. At a global level, we detected four genetic clusters with specimens from Indonesia, Brazil, and Japan as the most differentiated, whereas specimens from Europe, Hong Kong, and USA largely overlapped. Across the Alps, we detected a weak genetic structure and high levels of genetic admixture, supporting a scenario of rapid and human‐aided dispersal along transportation routes. While the genetic pattern suggests frequent re‐introductions into Switzerland from Italian sources, the recovery of a pair of full siblings in two consecutive years in Strasbourg, France, suggests the presence of an overwintering population north of the Alps. The suggestion of overwintering populations of Ae. albopictus north of the Alps and the expansion patterns identified points to an increased risk of further northward expansion and the need for increased surveillance of mosquito populations in Northern Europe.
Bilateral climate finance and food security in developing countries: A look at German donations to Sub‐Saharan Africa
Authors: Doku Isaac , Richardson Theophilus Edward , Essah Nicholas Kwame 
Published: July 2022

AbstractThis study seeks to assess whether the German bilateral climate finance (GCF) geared toward the agriculture sector of 35 SSA countries is helping achieve food security. In measuring food security, the study employed principal component analysis to generate an index for all four food security dimensions proposed by FAOSTAT‐food availability, access, stability, and utilization. A general composite food security index was also generated. System‐GMM was used to estimate the influence of GCF on all the food security components. The findings show that GCF improves food availability and general food security in SSA, but government expenditure is inadequate to do so. It was also found that agricultural technology or capacity moderates the effect of GCF on food availability and overall food security. Based on the findings of the study, it is clear that bilateral climate finance flow invested in agricultural technology coupled with an increase in government agricultural expenditure from the current 6% to 10% as proposed by the Malabo declaration will put SSA on a path to achieving food security. It is recommended that SSA countries deepen incentives to attract FDI inflows to the region due to its role in improving food security via food access.
The effects of land‐use conversion on evapotranspiration and water balance of subtropical forest and managed tea plantation in Taihu Lake Basin, China
Authors: Geng Jianwei , Li Hengpeng , Pang Jiaping , Zhang Wangshou , Shi Yunjie 
Published: July 2022

AbstractWidespread clearing of natural forests for tea plantations have profoundly altered the local water balance and energy budget. However, studies of comprehensive effects of land‐use conversion on energy and hydrological cycling are still rare. In this study, we used 5 years (2014–2018) of eddy covariance (EC) data, modelled estimates, and hydrological monitoring of different functional layers (canopy, litter and soil layers) to summarize the seasonal and inter‐annual variations and differences of evapotranspiration and water balance components in tea plantations (Camellia sinensis) and natural bamboo forests (Phyllostachysedulis). Results suggested the bamboo forest had higher actual evapotranspiration (ETa) (835 ± 5 mm) than the tea plantation (730 ± 19 mm), owing to differences in canopy conditions and plant physiology. Evident differences in ETa components were found between the tea plantation site and the bamboo forest site. The proportion of transpiration (Etr) was higher at the bamboo site (0.71–0.76) than the tea plantation site (0.60–0.65). Additionally, the soil evaporation ratio (0.10–0.13) was lower at the bamboo forest site than the tea plantation site (0.21–0.24) due to vegetation structure differences altering the radiation energy partitioning between the two sites. Moreover, the tea plantations were more susceptible to drought stress with low water storage in soil and simple rhizome‐root system. The comprehensive water holding capacity of canopy, litter, and soil layers of bamboo forest was 1.0–1.8 times of that in tea plantation. Compared with bamboo forest, pruning and losing of soil with intensive management activities enhanced drainage at the tea plantation site. This study provides insights into land‐use conversion of subtropical forest and managed tea plantation that have important implications on regional energy and water budgets.
Repurposing alpelisib, an anti‐cancer drug, for the treatment of severe TIE2‐mutated venous malformations: Preliminary pharmacokinetics and pharmacodynamic data
Authors: Remy Amandine , Tran Thai Hoa , Dubois Josée , Gavra Paul , Lapointe Chantal , Winikoff Rochelle , Facundo Garcia‐Bournissen , Théorêt Yves , Kleiber Niina 
Published: July 2022

AbstractExtensive venous malformations involving limbs severely impact quality of life, mostly due to chronic pain and functional limitations. But patients can also display coagulopathy with associated risks of life‐threatening thromboembolism and bleeding. Available pharmacological treatments (e.g., sirolimus) are not universally effective. Novel therapies are urgently needed for patients with treatment‐resistant venous malformations. We report three patients with TIE‐2 receptor mutations treated with alpelisib for 6 months (daily dosing: 50 mg for children weighing <50 kg and 100 mg for those >50 kg). Pain was controlled, gait improved, size of the abnormal venous network decreased, and coagulopathy dramatically improved. Drug exposure was highly variable, suggesting that alpelisib dosing should be individualized to patient's characteristics and guided by therapeutic drug monitoring.
A novel numerical method to evaluate the thermal conductivity of the unidirectional fiber‐reinforced composites
Authors: Cai Heng , Ye Junjie , Xi Jiale , Hong Yun , Shi Yang , Wang Yongkun , He Wangpei 
Published: July 2022

AbstractIn this study, an effective microscale method based on the parametric modeling scheme of the finite volume method is improved to evaluate the effective thermal conductivity and localized thermal fields of the fiber‐reinforced composites. By comparing with the finite element method and experimental data, it is indicated that the proposed microscale method exhibits a high accuracy in solving their effective properties. On this basis, the mesh sensitivity and fiber volume fraction influence on the thermal conductivity are both investigated. The number of 36 × 36 sub‐cells is employed as the RVE model to balance the computational efficiency and simulating accuracy. In addition, affected by the thermal conductivity and microstructure of constituent materials, the heat flux distribution near the interface between phenolic resin matrix and glass fiber is relatively uniform. The study on the influencing factors of the volume fraction shows that the equivalent thermal conductivity increases slowly at the low volume fraction, while the growth rate of the equivalent thermal conductivity increases significantly at the high‐volume fraction.
Compacted N‐Doped 3D Bicontinuous Nanoporous Graphene/Carbon Nanotubes@Ni‐Doped MnO2 Electrode for Ultrahigh Volumetric Performance All‐Solid‐State Supercapacitors at Wide Temperature Range
Authors: Qin Kaiqiang , Baucom Jesse , Diao Lechen , Lu Yunfeng , Zhao Naiqin 
Published: July 2022

AbstractDeveloping wide temperature range flexible solid‐state supercapacitors with high volumetric energy density is highly desirable to meet the demands of the rapidly developing field of miniature consumer electronic devices and promote their widespread adoption. Herein, high‐quality dense N‐doped 3D porous graphene/carbon nanotube (N‐3DG/CNTs) hybrid films are prepared and used as the substrate for the growth of Ni‐doped MnO2 (Ni‐MnO2). The integrated and interconnected architecture endows N‐3DG/CNTs@Ni‐MnO2 composite electrodes’ high conductivity and fast ion/electron transport pathway. Subsequently, 2.4 V solid‐state supercapacitors are fabricated based on compacted N‐3DG/CNTs@Ni‐MnO2 positive electrodes, which exhibit an ultrahigh volumetric energy density of 78.88 mWh cm‐3 based on the entire device including electrodes, solid‐state electrolyte, and packing films, excellent cycling stability up to 10 000 cycles, and a wide operating temperature range from −20 to 70 °C. This work demonstrates a design of flexible solid‐state supercapacitors with exceptional volumetric performance capable of operation under extreme conditions.
Animal obesity: What insights can a one health approach offer when it comes to veterinarians ‘making every contact count’?
Authors: Lynden Jenny , Hollands Teresa , Ogden Jane 
Published: July 2022

AbstractThere is an overweight/obesity crisis in both human and companion animal populations globally. Veterinarians have an ethical obligation to protect animal welfare and, therefore, have a duty to intervene by supporting their clients in changing care plans to mitigate and prevent pet overweight/obesity. Currently, there is limited evidence in veterinary contexts for when and how this can be done effectively. In contrast, a more comprehensive body of literature has been developed on how human healthcare practitioners ‘make every contact count’ (MECC). This review begins by briefly exploring the cross‐species multifactorial causes of overweight/obesity, before considering the literature regarding whether veterinarians reliably address overweight/obesity and the obstacles they encounter. The review then explores the evidence from human healthcare contexts in terms of how person‐centred and health ‘coaching‐style’ MECC interventions have supported weight management in adult and child populations and the barriers practitioners face when implementing these interventions. The final section interprets this literature to provide a fresh ‘lens’ through which veterinarians' concerns can be understood. Recommendations are made for enhancing veterinarians’ capacity to develop the knowledge and skills needed for successful outcomes when MECC. Opportunities for developing local multi‐stakeholder/agency teams taking a ‘one health’ approach are considered.
Interleukin-33 and soluble suppression of tumorigenicity 2 in scleroderma cardiac involvement
Authors: Iannazzo Francesco , Pellicano Chiara , Colalillo Amalia , Ramaccini Cesarina , Romaniello Antonella , Gigante Antonietta , Rosato Edoardo 
Published: July 2022

AbstractInterleukin (IL)-33 is part of the IL-1 family of cytokines and soluble suppression of tumorigenicity 2 (sST2) is part of the family of IL-1 receptors. In systemic sclerosis (SSc), IL-33 and sST2 are involved in cardiac manifestations such as diastolic dysfunction (DD), autonomic dysfunction (AD) and right ventricular–pulmonary arterial coupling assessed by tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP). Serum levels of IL33 and sST2 were assessed in 50 SSc patients and 14 healthy controls (HC). Clinical assessment, echocardiography and heart rate variability (HRV) analysis were performed in SSc patients. Serum levels of IL-33 and sST2 were significantly higher in SSc patients than HC. A linear positive correlation between modified Rodnan skin score and IL33 was observed. Serum values of sST2 were higher in SSc patients with DD than in patients without DD [15403 pg/ml (12,208–19,941) vs 8556 pg/ml (6820–11,036), p < 0.001]. sST2 showed a negative correlation with standard deviation of normal-to-normal RR intervals (SDNN) (r = − 0.281, p < 0.05) and positive correlation with low frequency/high frequency (LF/HF) (r = 0,349, p < 0.01). Negative linear correlation exists between sST2 and TAPSE/sPAP (r = − 0.398, p < 0.01). Serum levels of IL-33 and sST2 are higher in SSc patients than HC. Serum levels of sST2 are a potential marker of DD, AD and right ventricular–pulmonary arterial coupling.
A Continuum-Tensegrity Computational Model for Chondrocyte Biomechanics in AFM Indentation and Micropipette Aspiration
Authors: Arduino Alessandro , Pettenuzzo Sofia , Berardo Alice , Salomoni Valentina A. , Majorana Carmelo , Carniel Emanuele Luigi 
Published: July 2022

AbstractMechanical stimuli are fundamental in the development of organs and tissues, their growth, regeneration or disease. They influence the biochemical signals produced by the cells, and, consequently, the development and spreading of a disease. Moreover, tumour cells are usually characterized by a decrease in the cell mechanical properties that may be directly linked to their metastatic potential. Thus, recently, the experimental and computational study of cell biomechanics is facing a growing interest. Various experimental approaches have been implemented to describe the passive response of cells; however, cell variability and complex experimental procedures may affect the obtained mechanical properties. For this reason, in-silico computational models have been developed through the years, to overcome such limitations, while proposing valuable tools to understand cell mechanical behaviour. This being the case, we propose a combined continuous-tensegrity finite element (FE) model to analyse the mechanical response of a cell and its subcomponents, observing how every part contributes to the overall mechanical behaviour. We modelled both Atomic Force Microscopy (AFM) indentation and micropipette aspiration techniques, as common mechanical tests for cells and elucidated also the role of cell cytoplasm and cytoskeleton in the global cell mechanical response.
The Potential of Semaglutide Once-Weekly in Patients Without Type 2 Diabetes with Weight Regain or Insufficient Weight Loss After Bariatric Surgery—a Retrospective Analysis
Authors: Lautenbach Anne , Wernecke Marie , Huber Tobias B. , Stoll Fabian , Wagner Jonas , Meyhöfer Sebastian M. , Meyhöfer Svenja , Aberle Jens 
Published: July 2022

Abstract
Purpose
About 20–25% of patients experience weight regain (WR) or insufficient weight loss (IWL) after bariatric metabolic surgery (BS). Therefore, we aimed to retrospectively assess the effectiveness of adjunct treatment with the GLP-1 receptor agonist semaglutide in non-diabetic patients with WR or IWL after BS.

Materials and Methods
Post-bariatric patients without type 2 diabetes (T2D) with WR or IWL (n = 44) were included in the analysis. The primary endpoint was weight loss 3 and 6 months after initiation of adjunct treatment. Secondary endpoints included change in BMI, HbA1c, lipid profile, hs-CRP, and liver enzymes.

Results
Patients started semaglutide 64.7 ± 47.6 months (mean ± SD) after BS. At initiation of semaglutide, WR after post-bariatric weight nadir was 12.3 ± 14.4% (mean ± SD). Total weight loss during semaglutide treatment was − 6.0 ± 4.3% (mean ± SD, p < 0.001) after 3 months (3.2 months, IQR 3.0–3.5, n = 38) and − 10.3 ± 5.5% (mean ± SD, p < 0.001) after 6 months (5.8 months, IQR 5.8–6.4, n = 20). At 3 months, categorical weight loss was > 5% in 61% of patients, > 10% in 16% of patients, and > 15% in 2% of patients. Triglycerides (OR = 0.99; p < 0.05), ALT (OR = 0.87; p = 0.05), and AST (OR = 0.89; p < 0.05) at baseline were negatively associated with weight loss of at least 5% at 3 months’ follow-up (p < 0.05).

Conclusion
Treatment options to manage post-bariatric excess weight (regain) are scarce. Our results imply a clear benefit of adjunct treatment with semaglutide in post-bariatric patients. However, these results need to be confirmed in a prospective randomized controlled trial to close the gap between lifestyle intervention and revision surgery in patients with IWL or WR after BS.

Graphical abstract
Cancer Stem Cells and the Tumor Microenvironment: Targeting the Critical Crosstalk through Nanocarrier Systems
Authors: Nayak Aadya , Warrier Neerada Meenakshi , Kumar Praveen 
Published: July 2022

AbstractThe physiological state of the tumor microenvironment (TME) plays a central role in cancer development due to multiple universal features that transcend heterogeneity and niche specifications, like promoting cancer progression and metastasis. As a result of their preponderant involvement in tumor growth and maintenance through several microsystemic alterations, including hypoxia, oxidative stress, and acidosis, TMEs make for ideal targets in both diagnostic and therapeutic ventures. Correspondingly, methodologies to target TMEs have been investigated this past decade as stratagems of significant potential in the genre of focused cancer treatment. Within targeted oncotherapy, nanomedical derivates—nanocarriers (NCs) especially—have emerged to present notable prospects in enhancing targeting specificity. Yet, one major issue in the application of NCs in microenvironmental directed therapy is that TMEs are too broad a spectrum of targeting possibilities for these carriers to be effectively employed. However, cancer stem cells (CSCs) might portend a solution to the above conundrum: aside from being quite heavily invested in tumorigenesis and therapeutic resistance, CSCs also show self-renewal and fluid clonogenic properties that often define specific TME niches. Further scrutiny of the relationship between CSCs and TMEs also points towards mechanisms that underly tumoral characteristics of metastasis, malignancy, and even resistance. This review summarizes recent advances in NC-enabled targeting of CSCs for more holistic strikes against TMEs and discusses both the current challenges that hinder the clinical application of these strategies as well as the avenues that can further CSC-targeting initiatives.
Graphical abstract
Central role of CSCs in regulation of cellular components within the TME
Encapsulated trajectory tracking control for autonomous vehicles
Authors: Homolla Tobias , Winner Hermann 
Published: July 2022

AbstractThe motion control of autonomous vehicles with a modular, service-oriented system architecture poses new challenges, as trajectory-planning and -execution are independent software functions. In this paper, requirements for an encapsulated trajectory tracking control are derived and it’s shown that key differences to conventional vehicles with an integrated system architecture exist, requiring additional attention during controller design. A novel, encapsulated control architecture is presented that incorporates multiple extensions and support functions, fulfilling the derived requirements. It allows the application within the modular architecture without loss of functionality or performance. The controller considers vehicle stability and enables the yaw motion as an independent degree of freedom. The concept is applied and validated within the vehicles of the UNICARagil research project, that feature the previously described system architecture to increase flexibility of application by dynamically interconnecting services based on the current use-case.