bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth in individuals with SATB2‐associated syndrome
Authors: Zarate Yuri A. , Kannan Amrit , Bosanko Katherine A. , Caffrey Aisling R. 
Published: July 2022

AbstractSATB2‐associated syndrome (SAS) is an autosomal dominant multisystemic disorder caused by alterations in the SATB2 gene. In addition to a predominant neurodevelopmental phenotype, individuals with SAS often present with feeding difficulties and growth retardation that persist past infancy. In this study, we present growth and measurement data from 211 individuals (53.6% male, 46.4% female) with SAS due to different molecular mechanisms. To delineate growth in this population, we constructed SAS‐specific growth charts by sex from birth to 10 years of age. Smoothed SAS percentiles were superimposed with normative percentiles from WHO (birth to <24 months) and CDC (24 months to 10 years) growth charts. Individuals with SAS tend to display slower postnatal growth with 22.2% (32/144), 19.0% (26/137), and 21.6% having at least one weight, height, or weight‐for‐length /body mass index (BMI) measurement below −2 standard deviations, respectively. The SAS 50th centile BMI was consistently below the normative data 50th centile and negative mean Z‐scores were seen across almost all age groups analyzed for both genders. Individuals with chromosomal abnormalities displayed significantly lower weight for age Z‐score, height for age Z‐scores, occipitofrontal head circumference for age Z‐scores, and BMI for age Z‐scores compared to either missense or null variants.
Selective Confinement of Rare‐Earth‐Metal Hydrates by a Capped Metallo‐Cage under Aqueous Conditions
Authors: Tabuchi Ryosuke , Takezawa Hiroki , Fujita Makoto 
Published: July 2022

AbstractThe properties of rare‐earth‐metal ions in aqueous media often depend on their various hydration modes, which allow them to exist as monomeric or oligomeric species with different coordination numbers. Capturing rare‐earth‐metal ions in a confined cavity can fix their hydration modes and thus enable their intrinsic properties to be distinguished. However, the isolation of ionic species from bulk aqueous media is not an easy task due to competitive interaction with bulk water. Here, we report the encapsulation of hydrated rare‐earth‐metal ions in a hydrophobic cavity of a synthetic cage. Cap‐like counter anions located at the cage's portals play an important role in capturing the rare‐earth metals at a fixed position via electrostatic interactions. Preferential encapsulation of early lanthanoid (III) ions was observed even though all the rare‐earth metals have the same hydration number and geometry, as visualized by the competitive inclusion of a dye molecule. Accordingly, the early lanthanoid ion was selectively extracted from a mixture of two rare‐earth‐metal ions.
Isothermal Rolling Circle Amplification and Lanthanide‐Based FRET for Femtomolar Quantification of MicroRNA
Authors: Dekaliuk Mariia , Busson Pierre , Hildebrandt Niko 
Published: July 2022

AbstractQuantification of DNA and RNA biomarkers via isothermal amplification technologies can significantly simplify biosensing and clinical diagnostics. However, highly sensitive and wash‐free assay formats based on time‐resolved Förster resonance energy transfer (TR‐FRET) have been limited to terbium (Tb) based FRET pairs and their application on specialized clinical instruments. Here, we present the implementation of rolling circle amplification (RCA)‐FRET to europium‐dye (Eu‐ATTO620) FRET pairs and its application on standard benchtop fluorescence plate readers. Eu‐ATTO620 RCA‐FRET was used to quantify microRNA‐21 (miR‐21) in a 1 to 100 pM concentration range on a SPARK multimode plate reader system. Detection limits down to 120±20 fM (18±3 attomol of miR‐21) and quantification of endogenous miR‐21 from the plasma of ovarian cancer patients using a KRYPTOR clinical plate reader demonstrated the broad applicability and clinical relevance of Eu‐dye‐based RCA‐FRET. The extension to both Eu and Tb based TR‐FRET and to standard bioanalytical laboratory instruments has the potential to significantly broaden the application and versatility of RCA‐FRET for simple, highly‐sensitive, and multiplexed bioanalysis.
Base‐free Air Oxidation of Chitin‐derived Glucosamine to Glucosaminic Acid by Zinc Oxide‐supported Gold Nanoparticles
Authors: Zheng Yue , Xu Di , Zhang Lei , Chen Xi 
Published: July 2022

AbstractIn this study, glucosaminic acid (GlcNA) was produced with the highest yield of ∼85% from chitin biomass‐derived glucosamine (GlcN) at 35 °C under atmospheric air in water, by using zinc oxide‐supported gold nanoparticles (Au/ZnO). The Au/ZnO catalyst prepared by the deposition‐precipitation (DP) method displayed remarkably superior catalytic performance to that prepared by the deposition‐reduction (DR) method, which led to >2‐fold enhancement in product yield. A lower apparent activation energy (Ea) was observed over the Au/ZnO (DP) for GlcNA formation compared with the Au/ZnO (DR) catalyst. Based on control tests and structural characterizations, the average particle size of Au nanoparticles (NPs) and the surface oxygen vacancy (OV) sites were the crucial factors on the catalytic activity. The work puts forward a green, mild and efficient approach to synthesize valuable amino acid from ocean‐based chitin biomass resources with air as the oxidant, adding on new possibilities of chitin biorefinery.
Attempt to obtain the general relativistic planet's motion by special relativity techniques
Authors: Kubo Yoshio 
Published: July 2022

AbstractIt is attempted to derive the general relativistic equation of motion for a planet and its solution solely by the special relativity techniques. The motion of a planet relative to the Sun and that of the Sun to the planet are solved independently in a special relativistic framework using the perturbation theory in celestial mechanics. The solution reveals a nature of the structure of the spacetime under the gravitation of the Sun, and then its effect on the planet's motion is examined. When the motion thus examined are compared with the one obtained by the general relativity theory in post‐Newtonian approximation, both are different concerning the mean motion and the radius of the orbit but exactly the same as for the perihelion precession.
Zusammenwirken von Faser‐ und Betonstahlbewehrung bei biegebeanspruchten UHPC‐Bauteilen
Authors: Huß Michael , Waldenhofer Roland , Freytag Bernhard , Viet Tue Nguyen 
Published: July 2022

AbstractUltrahochfester Beton (UHPC) bietet ein großes Potenzial hinsichtlich nachhaltiger Lösungen für Instandsetzungen und Verstärkungen von bestehenden Tragwerken, aber auch für ressourcensparende Neubauten. In diesem Zusammenhang ist eine Kombination zwischen Mikrostahlfasern und gewöhnlicher Betonstahlbewehrung sinnvoll, da sich Synergieeffekte bezüglich der Rissbreitenbegrenzung und des Lastabfalls bei Verformungslokalisation erzielen lassen. Zur Bestätigung dieser Einschätzung wurden Biegeversuche mit unterschiedlichen Querschnittsgeometrien und Bewehrungskombinationen durchgeführt. Dank moderner Messmethoden konnte hierbei die Rissbreitenentwicklung über den gesamten Versuchsablauf, auch bei sehr feinen Rissen, kontinuierlich erfasst werden. Die Analyse der Versuchsergebnisse zeigt, dass bei der Ermittlung der Biegetragfähigkeit des Querschnitts die volle Wirkung der Betonstahl‐ (Fließen) und der Faserbewehrung (Nachrisszugfestigkeit) addiert werden dürfen, unabhängig vom Fasergehalt. Auf Basis der gewonnen Messdaten wurde außerdem ein vereinfachter Ansatz zur Berechnung der Rissbreiten im Grenzzustand der Gebrauchstauglichkeit abgeleitet.
Holy grail of tissue regeneration: Size
Authors: Chen Kellen , Henn Dominic , Gurtner Geoffrey C. 
Published: July 2022

AbstractCells and tissue within injured organs undergo a complicated healing process that still remains poorly understood. Interestingly, smaller organisms respond to injury with tissue regeneration and restoration of function, while humans and other large organisms respond to injury by forming dysfunctional, fibrotic scar tissue. Over the past few decades, allometric scaling principles have been well established to show that larger organisms experience exponentially higher tissue forces during movement and locomotion and throughout the organism's lifespan. How these evolutionary adaptations may affect tissue injury has not been thoroughly investigated in humans. We discuss how these adapations may affect healing and demonstrate that blocking the most evolutionary conserved biologic force sensor enables large organisms to heal after injury with true tissue regeneration. Future strategies to disrupt tissue force sensors may unlock the key to regenerating after injury in a wide range of organ systems.
Penalized estimation of a class of single‐index varying‐coefficient models for integrative genomic analysis
Authors: Ng Hoi Min , Jiang Binyan , Wong Kin Yau 
Published: July 2022

AbstractRecent technological advances have made it possible to collect high‐dimensional genomic data along with clinical data on a large number of subjects. In the studies of chronic diseases such as cancer, it is of great interest to integrate clinical and genomic data to build a comprehensive understanding of the disease mechanisms. Despite extensive studies on integrative analysis, it remains an ongoing challenge to model the interaction effects between clinical and genomic variables, due to high dimensionality of the data and heterogeneity across data types. In this paper, we propose an integrative approach that models interaction effects using a single‐index varying‐coefficient model, where the effects of genomic features can be modified by clinical variables. We propose a penalized approach for separate selection of main and interaction effects. Notably, the proposed methods can be applied to right‐censored survival outcomes based on a Cox proportional hazards model. We demonstrate the advantages of the proposed methods through extensive simulation studies and provide applications to a motivating cancer genomic study.
Technological advances in ocular trabecular meshwork in vitro models for glaucoma research
Authors: Bikuna‐Izagirre Maria , Aldazabal Javier , Extramiana Leire , Moreno‐Montañés Javier , Carnero Elena , Paredes Jacobo 
Published: July 2022

AbstractGlaucoma is the leading cause of irreversible blindness worldwide and is characterized by the progressive degeneration of the optic nerve. Intraocular pressure (IOP), which is considered to be the main risk factor for glaucoma development, builds up in response to the resistance (resistance to what?) provided by the trabecular meshwork (TM) to aqueous humor (AH) outflow. Although the TM and its relationship to AH outflow have remained at the forefront of scientific interest, researchers remain uncertain regarding which mechanisms drive the deterioration of the TM. Current tissue‐engineering fabrication techniques have come up with promising approaches to successfully recreate the TM. Nonetheless, more accurate models are needed to understand the factors that make glaucoma arise. In this review, we provide a chronological evaluation of the technological milestones that have taken place in the field of glaucoma research, and we conduct a comprehensive comparison of available TM fabrication technologies. Additionally, we also discuss AH perfusion platforms, since they are essential for the validation of these scaffolds, as well as pressure–outflow relationship studies and the discovery of new IOP‐reduction therapies.
Pursuing a strategy of ‘common benefit’ in business: The adoption of the benefit corporation model in Italy
Authors: Marchini Pier Luigi , Tibiletti Veronica , Fellegara Anna Maria , Mazza Tatiana 
Published: July 2022

AbstractA benefit corporation (BC) is a for‐profit company that pursues common benefits for stakeholders. Adopting institutional theory, we analyse the characteristics of the company in relation to the common benefits a BC pursue and how BC model fits with corporate social responsibility (CSR) practices defined in literature. BCs were introduced by a 2016 law in Italy, that was the first European country to approve legislation for BCs, under which a company must indicate its specific common benefit in its articles of association (AoAs). We run a multivariate regression on data from a content analysis on companies' AoA and then use questionnaire data to perform a cluster analysis and interviews to provide additional information. We show that larger and profitable firms focus on customers, while mature firm focus on the environment in the definition of common benefit in AoA. There is resistance to profit sharing. Industry and location specific are important drivers. Among first evidences, it is interesting to see that the most frequent perceived advantage of BC status is differentiation, BC and BCorp do not in practice overlap, and ownership is the main promoter of the change to become BC.
Importance of green innovation for business sustainability: Identifying the key role of green intellectual capital and green SCM
Authors: Suki Norazah Mohd , Suki Norbayah Mohd , Sharif Arshian , Afshan Sahar , Rexhepi Gadaf 
Published: July 2022

AbstractOrganizations, while transforming resources into products and services and then into financial gains, consecutively neglect the adverse effects that are being caused to the environment and society. Hence, organizations should not focus on the financial aspects only; rather, they need to strive for business sustainability (BS). For an organization to become more sustainable, they need to tap and excel into green innovation (GIN), followed by green intellectual capital (GIC), whereas the role of green supply chain management practices (GSCMP) in this objective cannot be ignored. To fill this gap, we have established a framework based on the natural resource‐based view theory and extant literature that offers a foundation for sculpturing the process by which GIN was observed to capture BS through GIC and GSCMP. Primary data were collected from the Malaysian manufacturing industries, and partial least square structural equation modeling (PLS‐SEM) was applied to the sample of 243 respondents. The key findings reported that GIN has a positive and significant relationship with GIC, GSCMP, and BS. Further, GIC and GSCMP also positively and significantly affect BS. These findings have some certain recommendations for policymakers that the present study proposed. Mainly organizations need to develop their green and sustainable resources, which will help them develop according to the principles of BS and gain a competitive advantage in the long run. In the end, there are certain limitations of the present study on which the possibilities of future research are drawn.
Transient cortical blindness, a rare complication during cerebral digital subtraction angiography: A case report and literature review
Authors: Sarkodie Benjamin Dabo , Jimah Bashiru Babatunde , Anim Dorothea , Jackson Emmanuel , Brakohiapa Edmund , Anaglate Awo Yaa Oduro 
Published: July 2022

AbstractTransient cortical blindness (TCB) is a rare consequence of cerebral angiography with no recognized cause. TCB was observed in a patient with a wide‐neck cavernous aneurysm during digital subtraction angiography. One hour after angiography, vision returned spontaneously, with no neurological damage. An MRI was performed three hours after the incident and revealed no abnormalities.
Lightsheet Microscopy
Authors: Dyer Laura , Parker Andrew , Paphiti Keanu , Sanderson Jeremy 
Published: July 2022

AbstractIn this paper, we review lightsheet (selective plane illumination) microscopy for mouse developmental biologists. There are different means of forming the illumination sheet, and we discuss these. We explain how we introduced the lightsheet microscope economically into our core facility and present our results on fixed and living samples. We also describe methods of clearing fixed samples for three‐dimensional imaging and discuss the various means of preparing samples with particular reference to mouse cilia, adipose spheroids, and cochleae. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.
Serum microRNAs are key predictors of long‐term heart failure and cardiovascular death after myocardial infarction
Authors: Rincón Luis M. , Rodríguez‐Serrano Macarena , Conde Elisa , Lanza Val F. , Sanmartín Marcelo , González‐Portilla Paz , Paz‐García Marta , Del Rey José Manuel , Menacho Miriam , García Bermejo María‐Laura , Zamorano José L. 
Published: July 2022

AbstractBackgroundPatients with acute myocardial infarction (MI) are at high risk of upcoming events, in particular heart failure (HF), but reliable stratification methods are lacking. Our goal was to evaluate the potential role of circulating miRNAs as prognostic biomarkers in patients presenting with MI.Methods and resultsWe conducted a prospective study among 311 consecutive patients hospitalized with MI (65% ST‐segment elevation MI & median age of 55 years) with long‐term follow‐up. An initial screening was conducted to select candidate miRNAs, with subsequent study of 14 candidate miRNAs. The primary outcome was the composite of hospital admission for HF or cardiovascular death. During a mean follow‐up of 2.1 years miR‐21‐5p, miR‐23a‐3p, miR27b‐3p, miR‐122‐5p, miR210‐3p, and miR‐221‐3p reliably predicted the primary outcome. Multivariate Cox regression analyses highlighted that miR‐210‐3p [hazard ratio (HR) 2.65 per 1 SD increase, P < 0.001], miR‐23a‐3p (HR 2.11 per 1 SD increase, P < 0.001), and miR‐221‐3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long‐term New York Heart Association (NYHA) functional class. These three miRNAs clearly improved the performance of multivariate clinical models: ΔC‐statistic = 0.10 [95% confidence interval (CI), 0.03–0.17], continuous net reclassification index = 34.8% (95%CI, 5.8–57.4%), and integrated discrimination improvement (P < 0.001).ConclusionsThis is the largest study evaluating the prognostic value of circulating miRNAs for HF‐related events among patients with MI. We show that several miRNAs predict HF hospitalizations, cardiovascular mortality, and poor long‐term NYHA status and improve current risk prediction methods.
Materials design and system structures of solar steam evaporators
Authors: Xiao Bo , Zhou Wei , Yu Fang , Wang Junshi , Xiong Xin , Liu Gang , Xia Yue , Wang Xianbao 
Published: July 2022

AbstractSolar energy, as a low‐cost, abundant and clean energy, has enormous potential to alleviate water shortages. Solar steam generation (SSG) is a promising solar‐to‐thermal conversion technology that has been effectively applied for clean water production, desalination and sewage treatment. In this review, the recent developments of photothermal materials from a light absorption capacity and structural design have been summarized. Based on thermal management and transporting water, the advantages and disadvantages of volume systems, surface system and isolation system to get the optimal solar evaporator structure have been presented. This work aims to provide a pointer for rational design of photothermal evaporators for clean water production and a direction to large engineering systems for realizing commercialization of SSG.
Aminophosphate precursors for the synthesis of near‐unity emitting InP quantum dots and their application in liver cancer diagnosis
Authors: Zhang Yanbin , Lv Yanbing , Li Lin‐Song , Zhao Xue‐Jie , Zhao Mei‐Xia , Shen Huaibin 
Published: July 2022

AbstractInP quantum dots (QDs) are a promising and environment‐friendly alternative to Cd‐based QDs for in vitro diagnostics and bioimaging applications. However, their poor fluorescence and stability severely limit their biological applications. Herein, we synthesize bright (∼100%) and stable InP‐based core/shell QDs by using cost‐effective and low‐toxic phosphorus source, and then aqueous InP QDs are prepared with quantum yield over 80% by shell engineering. The immunoassay of alpha‐fetoprotein can be detected in the widest analytical range of 1–1000 ng ml−1 and the limit of detection of 0.58 ng ml−1 by using those InP QDs‐based fluorescent probes, making it the best‐performing heavy metal‐free detection reported so far, comparable to state‐of‐the‐art Cd‐QDs‐based probes. Furthermore, the high‐quality aqueous InP QDs exhibit excellent performance in specific labeling of liver cancer cells and in vivo tumor‐targeted imaging of live mice. Overall, the present work demonstrates the great potential of novel high‐quality Cd‐free InP QDs in cancer diagnosis and image‐guided surgery.
Forecasting chlorophyll‐a concentration using empirical wavelet transform and support vector regression
Authors: Yu Jin‐Won , Kim Ju‐Song , Jong Yun‐Chol , Li Xia , Ryang Gwang‐Il 
Published: July 2022

AbstractAccurate forecast of chlorophyll‐a concentration of water bodies is important for aquatic management because it can support management decisions with future information. In this regard, this paper proposes a new chlorophyll‐a forecast method that combines empirical wavelet transform, support vector regression, and sine cosine algorithm. Chlorophyll‐a concentration data are decomposed by empirical wavelet transform, and then, support vector regression is employed to predict decomposed components, and finally, forecast value is obtained by reconstructing the predicted values for the decomposed components. Hyperparameters of support vector regression models are optimized by sine cosine algorithm. Our model is evaluated by chlorophyll‐a concentration data of Lake Kasumigaura, Japan. For the purpose of comparison, several other models are also developed. Result indicates that our method shows better forecast performance than other competitor models. This study demonstrates that data processing by empirical wavelet transform can significantly improve forecast accuracy and our method is a promising new forecast method for lake chlorophyll‐a concentration.
Effect of roasting and frying treatments on aflatoxins and capsaicinoids content and nutritional profile of green chilies (Capsicum annumL.)
Authors: Bashir Omar , Sharma Vasudha , Hussain Syed Zameer , Naseer Bazila , Amin Tawheed , Ameer Kashif , Bhat Shakeel Ahmad , Manzoor Sobiya , Mohamed Ahmed Isam A. 
Published: July 2022

AbstractThis study was conducted to assess the effect of two thermal treatments, viz. roasting and pan frying (deep frying), on nutritional profile, aflatoxin, and capsaicin content in green chilies. Green chilies were subjected to roasting and frying to reduce the aflatoxin contamination, besides retaining their pungency and nutritional profile. Reversed‐phase HPLC was employed to determine the levels of aflatoxins B1, B2, G1, and G2 in thermally treated and control samples. The proximate compositions of roasted and fried chili samples were significantly (p ≤ .05) different from raw chili (control), except ash content. Vitamin A levels decreased significantly (p ≤ .05) during roasting and were undetected in fried chili samples. Likewise, vitamin C was undetected in both roasted and fried chili samples. Significantly decreasing (p ≤ .05) trends were noticed in capsaicinoids viz. capsaicin and dihydrocapsaicin contents including Scoville Heat Units (SHU) during roasting and frying. However, retention of capsaicinoids was higher in roasted chilies (730.00 ± 4.90 mg/kg) than fried samples (502.56 ± 5.10 mg/kg). The levels of all the four major aflatoxins (AFs)‐ AFB1, AFB2, AFG1, and AFG2 recorded in control were much higher than the limits prescribed by the European Union for spices. Both thermal treatments (roasting and frying) employed proved to be effective in reducing aflatoxins like AFB2, AFG1, and AFG2 in chilies to below the prescribed limits, while as the level of AFB1 was reduced below the limits by only the frying method. This study therefore indicated the substantial impact of frying on aflatoxins.