bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose-dependent benefits of iron-magnetic nanoparticle-coated human umbilical-derived mesenchymal stem cell treatment in rat intracranial hemorrhage model
Authors: Chen Kuan-Hung , Chai Han-Tan , Lin Kun-Chen , Chiang John Y. , Sung Pei-Hsun , Chen Chih-Hung , Yip Hon-Kan 
Published: June 2022

Abstract
Background
This study tested whether two doses of human umbilical-derived mesenchymal stem cells (hUC-MSCs) were superior to one dose for protecting the brain against intracranial hemorrhage (ICH) induced by intracranial injection collagenase and the capacity of ironic-magnetic-nanoparticles (Ir-MNa) coated hUC-MSCs tracked by MRI.

Methods and results
Adult male SD rats (n = 40) were equally categorized into group 1 (sham-operated-control), group 2 (ICH), group 3 [ICH + Ir-MNa-coated hUC-MSCs/1.2 × 106 cells with an extracorporeal magnet over rat head (eCMag)/administered by left internal carotid artery (LICA) at post-3 h ICH], and group 4 (ICH + Ir-MNa-coated hUC-MSCs/1.2 × 106 cells with an eCMag/administered post-3 h ICH by LICA and 24 h by IV) and euthanized by day 28. The result showed that by day 28 after ICH induction the neurological function was severely impaired in group 2 than in group 1 that was significantly improved in group 3 and further significantly improved in group 4, whereas ICH volume exhibited an opposite pattern of neurological impairment among the groups (all p < 0.0001). Brain MRI demonstrated that by 4 h after ICH, Ir-MNa-coated hUC-MSCs were abundantly identified in ischemic area in group 4. The protein expressions of inflammatory (TNF-α/MMP-9/IL-1ß/iNOS)/oxidative-stress (NOX-1/NOX-2/oxidized protein)/apoptotic (caspase-3/mitochondrial Bax/PARP)/fibrotic (Smad3/TGF-ß)/mitochondrial-damaged (cytosolic-cytochrome-C) biomarkers displayed an identical pattern of neurological impairment among the groups (all p < 0.0001). The cellular expressions of inflammation (CD68+/CD11b+)/brain edema (AQP4+) biomarkers exhibited an identical pattern, whereas the neuronal-myelin (Doublecortin+/NeuN/nestin) biomarkers displayed an opposite pattern of neurological impairment (all p < 0.0001).

Conclusion
Two doses of hUC-MSCs were superior to just one dose for protecting the brain against ICH-induced damage and Ir-MNa-coated hUC-MSCs offered a well adopted method for tracking hUC-MSCs homing into the brain.
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
Authors: Chen Qun , Li Jiajia , Shen Peng , Yuan Hao , Yin Jie , Ge Wanli , Wang Wujun , Chen Guangbin , Yang Taoyue , Xiao Bin , Miao Yi , Lu Zipeng , Wu Pengfei , Jiang Kuirong 
Published: June 2022

AbstractPancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally, robust biomarkers and satisfactory therapeutic strategies for clinical use in PC patients are still lacking. Circular RNAs (circRNAs) are a new type of non-coding RNA originating from precursor messenger RNAs, with a covalent continuous closed-loop structure, strong stability and high specificity. Accumulating evidence suggests that circRNAs may participate in PC development and progression. Abnormal expression of circRNAs in PC is considered a vital factor that affects tumor cell proliferation, migration, invasion, apoptosis, angiogenesis and drug resistance. In this review of relevant articles published in recent years, we describe the basic knowledge concerning circRNAs, including their classification, biogenesis, functions and research approaches. Moreover, the biological roles and clinical significance of circRNAs related to PC are discussed. Finally, we note the questions remaining from recent studies and anticipate that further investigations will address these gaps in knowledge in this field. In conclusion, we expect to provide insights into circRNAs as potential targets for specific PC diagnosis and treatment in the future.
Performance and time improvement of LT code-based cloud storage
Authors: Chakani Nastaran , Mirrezaei Seyed Masoud , Hodtani Ghosheh Abed 
Published: June 2022

AbstractOutsourcing data on cloud storage services has already attracted great attention due to the prospect of rapid data growth and storing efficiencies for customers. The coding-based cloud storage approach can offer a more reliable and faster solution with less storage space in comparison with replication-based cloud storage. LT codes are the famous member of the rateless code family that can improve performance of storage systems utilizing good degree distributions. Since degree distribution plays a key role in LT codes performance, recently introduced Poisson robust soliton distribution (PRSD) and combined Poisson robust soliton distribution (CPRSD) motivate us to investigate LT code-based cloud storage system. So, we exploit LT codes with new degree distributions to provide lower average degree and higher decoding efficiency, specifically when receiving fewer encoding symbols, compared with popular degree distribution, robust soliton distribution (RSD). In this paper, we show that proposed cloud storage outperforms traditional ones in terms of storage space and robustness encountering unavailability of encoding symbols, due to compatible properties of PRSD and CPRSD with cloud storage essence. Furthermore, a modified decoding process is presented based on required encoding symbols behavior to reduce data retrieval time. Numerical results confirm improvement of cloud storage performance.
Theory of planned behaviour-based interventions in chronic diseases among low health-literacy population: protocol for a systematic review
Authors: Paul Biswajit , Kirubakaran Richard , Isaac Rita , Dozier Marshall , Grant Liz , Weller David ,   RESPIRE collaboration
Published: June 2022

Abstract
Background
Health behaviour can change outcomes in both healthy and unhealthy populations and are particularly useful in promoting compliance to treatment and maintaining fidelity to care seeking and follow-up options in chronic diseases. Interventions to change health behaviour based on psychological theory are more often successful than those without any underlying theory. The theory of planned behaviour (TPB) is one such psychological theory which had been found to predict human behaviour with respect to disease prevention and when applied to interventions can change the outcomes of diseases. Most of the research evidence of TPB-based interventions have been from developed world. Evidence is required whether TPB-based interventions can be applied and works in low-resource, low health-literacy settings of low- and middle-income countries (LMICs).

Methods
The protocol has been developed as per PRISMA-P guidelines and incorporates PICO (population, intervention, comparison, outcomes) framework for describing the methodology. Population above 18 years of age and having any chronic disease (as defined for this systematic review) will be selected, while any health or educational intervention based on constructs of TPB will be included. Comparison will be with non-TPB-based interventions or treatment as usual without any intervention, and the primary outcome will be the behaviour change effected by the TPB-based intervention. Intervention studies will be considered, and relevant databases like MEDLINE, Embase, Cochrane Library and ProQuest will be explored. Data extraction will done in a standardised form, and risk-of-bias assessment will be done using the Cochrane Collaboration’s tools for such assessment. Narrative synthesis of the selected studies will be done to draw the conclusions, and meta-analysis will be done to calculate the effect estimates with I-squared statistics to describe the heterogeneity.

Discussion
This systematic review will provide new evidence on fidelity and effectiveness of the TPB-based interventions among chronic disease patients from low health literacy, resource-poor background. It will inform of how to plan and use such interventions to change health behaviour in chronic disease patients, particularly in LMIC settings.

Systematic review registration
PROSPERO CRD42018104890.
Refinements of some classical inequalities via superquadraticity
Authors: Nikolova Ludmila , Persson Lars-Erik , Varošanec Sanja , Yimer Markos Fisseha 
Published: June 2022

AbstractSome new refined versions of the Jensen, Minkowski, and Hardy inequalities are stated and proved. In particular, these results both generalize and unify several results of this type. Some results are also new for the classical situation.
Factors influencing suicidal tendencies during COVID-19 pandemic in Korean multicultural adolescents: a cross-sectional study
Authors: Park Ju-Young , Lee Insook 
Published: June 2022

Abstract
Background
There is concern that the COVID-19 pandemic has had a negative impact on the psychological wellbeing of many populations, including increase of fear, anxiety, and uncertainty. Since the start of the COVID-19 pandemic, adolescents specifically have experienced direct and indirect impacts on their mentally, resulting in severe depression, self-harm and suicide. This study aimed to identify factors influencing suicidal tendencies and the mental health status of multicultural adolescents in Korea during the COVID-19 pandemic.

Methods
This cross-sectional study was conducted with 784 multicultural adolescents (Korean fathers and foreign mothers) who participated in the 16th national Korean Youth Risk Behaviour online survey. Research variables were measured using self-reported questionnaires for mental health and suicidal tendencies. Data was analysed using SPSS 26.0 program.

Results
The factors influencing suicidal tendencies (contemplating suicide, suicidal plans, and suicide attempts) were sexual intercourse experience (adjusted odds ratio [aOR], 7.67, 5.04, 7.10), depressive mood (aOR 1.03, 0.98, 0.97, 0.90), and unhappiness (aOR 13.00, 7.28, 5.56).

Conclusions
In conclusion, the factors that affect suicidal tendencies showed sexual intercourse experience, depressive mood and unhappiness. Screening for suicidal tendencies and suicide prevention programs that consider the significant factors that affect suicidal tendencies should be developed for multicultural adolescents. School health professions and mental health counselors at schools need to emphasize the mental health and psychosocial support needs of senior high school students.
Glass in Rome during the transition from late antiquity to the early Middle Ages: materials from the Forum of Caesar
Authors: Boschetti Cristina , Kindberg Jacobsen Jan , Parisi Presicce Claudio , Raja Rubina , Schibille Nadine , Vitti Massimo 
Published: June 2022

Abstract
Base glasses from the eastern Mediterranean which circulated in Rome between the fifth and tenth centuries bear witness to the persistence of long-distance trade after the fall of the Western Roman Empire. LA-ICP-MS data of vessel fragments, mosaic tesserae and indicators of production excavated in the Forum of Caesar identify a substantial amount of recycled Roman base glass mixed with later Foy.2.1 glass, flanked by Roman Mn and Sb, Foy 2.1, Foy 3.2, HIMT and Levantine I base glass. Recycled compositions have been documented since the fifth century. Base glasses dating later than the seventh century are completely missing, indicating an interruption or a strong contraction of the commercial flows sometime in the seventh century. The identification of a small number of medieval vessels is coherent with the presence in the area of a dwelling context of elevated status. The compositional features of these glasses reflect the intensification of recycling in the eight century, when the commerce of cullet became increasingly international and some fresh glass continued to travel along the Adriatic trade routes.
Ancient rivers shaped the current genetic diversity of the wood mouse (Apodemus speciosus) on the islands of the Seto Inland Sea, Japan
Authors: Sato Jun J. , Yasuda Kouki 
Published: June 2022

AbstractThe current distributions of organisms have been shaped by both current and past geographical barriers. However, it remains unclear how past geographical factors—currently cryptic on the sea floor—affected the current distributions of terrestrial animals. Here, we examined the effects of currently cryptic ancient rivers on current genetic differentiation of the large Japanese wood mouse,Apodemus speciosus, which inhabits islands in the Seto Inland Sea, Japan. Genome-wide polymorphisms were identified by GRAS-Di (Genotyping by Random Amplicon Sequencing, Direct) analysis of 92A. speciosusindividuals. Maximum-likelihood analysis was performed with 94,142 single nucleotide polymorphisms (SNPs) identified by GRAS-Di analyses. Ancient rivers were visualized by Geographic Information System (GIS) channel analysis. Maximum-likelihood analysis showed strong support for the monophyly of each population in the islands in the Seto Inland Sea; it also showed close relationships between Innoshima-Ikuchijima, Ohmishima-Hakatajima-Oshima, Ohmishima-Hakatajima, Ohsakikamijima-Ohsakishimojima, Kamikamagarijima-Shimokamagarijima, and Kurahashijima-Etajima islands. The principal component analyses of the SNPs also supported these relationships. Furthermore, individuals from islands located on the east and west sides of the main stream of the ancient river were clustered on each side with strong support. These phylogenetic relationships were completely congruent with the paleogeographic relationships inferred from ancient rivers. In conclusion, the findings demonstrated that the current distribution of genetically distinct island lineages was shaped by ancient rivers that are currently submerged beneath the Seto Inland Sea, Japan.
Comparison of matrix metalloproteinase 9 and 14 levels in vitreous samples in diabetic and non-diabetic patients: a case control study
Authors: Ünal A. , Baykal O. , Öztürk N. 
Published: June 2022

Abstract
Background
MMP-9 plays a prominent role in inflammation and MMP-14 take part in angiogenesis. The objective of this study is to compare MMP-9 and MMP-14 levels between diabetic and non-diabetic patients.

Methods
The patients who scheduled for pars plana vitrectomy were included in our study. Patients are divided into 2 groups: the diabetic group and non-diabetic group. Age, gender, intraocular pressure(IOP), visual acuity (VA) were reported. Color fundus photography, fundus fluorescein angiography, optic coherence tomography (OCT) were performed before and after the operation. MMP-9 and MMP-14 levels in vitreous samples were analyzed with a reader device by ELISA method. Mann–Whitney U test and logistic regressions were used in statistical analysis, p < 0.05 accepted as statistically significant.

Results
70 eyes of 70 patients who received pars plana vitrectomy were enrolled in the study and divided into 2 groups: 34 patients in the diabetic group, 36 patients in the non-diabetic group. The average age of diabetic patients was 60.14 ± 10.20, and non-diabetic patients was 64.22 ± 11.16, respectively. The average MMP-9 (0.67 ± 0.66 ng/ml) and MMP-14 (0.16 ± 0.45 ng/ml) values in the diabetic group were significantly higher than the average MMP-9 (0.21 ± 0.05 ng/ml) and MMP-14 (and 0.07 ± 0.02 ng/ml) values in the non-diabetic group (P < 0.01). Also, it was observed that MMP-9 and MMP-14 levels increases as the diabetic disease duration increases. The risk of diabetes incidence increased with high levels of MMP-9 and MMP-14.

Conclusion
Due to the higher levels of MMP-9 and MMP-14 in the pathogenesis of diabetic retinopathy, these proteins may probably be among the therapeutic targets in the prevention and treatment of retinopathy.
Symptomatic absorption of normal saline during transurethral resection of the prostate: a case report
Authors: Okuma Naomi , Hino Hideki , Kuroki Madoka , Matsuura Tadashi , Mori Takashi 
Published: June 2022

Abstract
Background
Transurethral resection of the prostate (TUR-P) could incidentally cause hyponatremia, known as TUR syndrome due to intravascular absorption of non-electrolytic irrigation fluid. Recently, normal saline has been used as an irrigation fluid in a new system named TURis (TUR in saline) to prevent TUR syndrome. However, rapid massive absorption of normal saline can also cause other systemic adverse events.

Case presentation
A 71-year-old man underwent TURis for benign prostatic hyperplasia under spinal anesthesia. The patient lost consciousness which led upper airway obstruction and hypoxia 30 min after the surgery began. Blood gas test indicated hyperchloremic metabolic acidosis. While vasoactive agents were ineffective, the administration of bicarbonate significantly improved the symptoms and restored blood pressure.

Conclusion
We experienced a case of hyperchloremic metabolic acidosis with decreased level of consciousness and hypotension during TURis. Administration of bicarbonate, but not phenylephrine, was effective for recovering blood pressure.
The cross-cultural validation of the technology-enhanced social constructivist learning environment questionnaire in the Iraqi Kurdistan Region
Authors: Mohammed Saif Husam , Kinyó László 
Published: June 2022

AbstractThis study’s primary aim is to validate a research instrument in Iraqi Kurdistan middle and secondary schools to explore learners’ perspectives concerning social constructivist learning environments and e-learning outcomes. The research instrument was updated and devised based on Aldridge, Fraser, Taylor, and Chen's (Aldridge et al., International Journal of Science Education 22:37–55, 2000) Constructivist Learning Environment (CLES) Survey. Additionally, it also contains two newly developed rating scales that have been taken from Luckay and Laugksch (Luckay and Laugksch, Research in Science Education 45:1–22, 2015), and a perceived e-learning outcomes scale adopted from Sultan, Woods, and Koo (Sultan et al., Educational Technology and Society 14:149–163, 2011). The instrument included seven prominent social constructivist learning dimensions and plus perceived e-learning outcomes, namely: Respect for Difference, Learner Investigation, Critical Voice, Learner Negotiation, Individual Relevance, Shared Control, Uncertainty and Perceived e-Learning Outcomes. For this study, empirical data were gathered from 1289 upper primary and secondary school students in the Iraqi Kurdistan Region. The research instrument possessed factor structure, discriminant validity, and internal consistency reliability based on the results of data analysis. Consequently, the validity and reliability of Arabic language and Kurdish language versions of the survey were verified. Hence, the principal data are sufficient for additional empirical research involving path model evaluation in order to discern any correlations between the variables included in the research model.
Ultrastructural studies on effect of Caesalpinia bonducella and Croton joufra, traditionally used anthelmintics, on Hymenolepis diminuta and Syphacia obvelata
Authors: Gogoi Shyamalima , Soren Amar Deep , Yadav Arun K. 
Published: June 2022

Abstract
Background
The leaves of Caesalpinia bonducella and Croton joufra are traditionally used anthelmintics by the Mishing tribe in Assam, India. In vitro studies have shown them to be effective as anthelmintics. This study evaluates their effects on the tegument of Hymenolepis diminuta (Cestoda) and the cuticle of Syphacia obvelata (Nematoda) using scanning electron microscopy. The effects were compared with negative control parasites and the one exposed to reference drugs (positive control). Parasites were collected from freshly necropsied animals and were exposed to 30 mg/ml of the methanolic leaf extract of the two plants. Paralysed worms were then processed for ultrastructural studies as per standard methods.

Results
Adult and juvenile H. diminuta exposed to extracts of both the test plants showed damaged scolex, suckers and altered tegument. S. obvelata treated with C. bonducella showed damaged apical region, closed mouth, and a damaged cuticle. Worms exposed to C. joufra showed deformations in the apical region with closed mouth, loss of cephalic papillae, distorted lips and damaged cuticle.

Conclusions
In conclusion, the findings of this study demonstrate that the extract of these plants acts via a tegumental/cuticular mode. This study also validates the traditional knowledge system of the Mishing tribe in Assam, India.
Detection, characterization and virulence analysis of nucleopolyhedrovirus isolated from the cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae)
Authors: El Sayed Yasmein A. , Sayed Samy , Magdy Aml , Elmenofy Wael 
Published: June 2022

Abstract
Background
In the present study, detection, characterization and virulence analysis of a field collected nucleopolyhedrovirus isolated from the cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) was carried out. The obtained isolate, named SpliNPV-YW, was collected from diseased S. littoralis larvae in El-Menoufia governorate, Egypt.

Results
Transmission electron microscopy showed the presence of typical occlusion bodies with average size of (1.06 × 1.19 µm). Upon digestion using two different endonucleases, PstI and ScaI, no clear difference was detected in the collected isolate (SpliNPV-YW) DNA genome pattern compared to the reference strain SpliNPV-AN1956. The evolutionary analysis of the polyhedrin gene's partial nucleotide sequence revealed that SpliNPV-YW isolate was closed and had a genetic origin with the NPV isolate SpliMNPV-A26-5 that belongs to group II NPVs with identity of 99.7%. The median lethal concentration (LC50) and the median lethal time (LT50) values were estimated for second and fourth larval instars of S. littoralis. The LC50 values were 2.8 × 104 OB/ml for second larval instar and 5.2 × 105 OB/ml for fourth larval instar after 10 days of treatment. Regarding the speed of killing of the viral isolate, the results showed that the LT50 value for the second instar larvae (LT50 = 5.5 days) was lower than that of the fourth instar larvae (LT50 = 6.2 days) at concentrations of 4.3 × 1010 (ob/ml) and 1.2 × 1011 (ob/ml) for second and fourth instar larvae, respectively.

Conclusions
Host specificity and virulence characteristics make SpliNPV-YW isolate a good potential to be utilized as a candidate biopesticide for the control of S. littoralis population in Egypt.