bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social media analysis and statistical processing of tweets about COVID-19
Authors: Золотарев О.В. , Хакимова А.Х. 
Published: September 2022

Анализируются сообщения в «Твиттере» для выделения наиболее актуальных тем, связанных с распространением коронавируса в мире на примере русскоязычного сегмента «Твиттера». Для анализа близости слов в тексте и формирования терминологических цепочек слов использовался метод машинного обучения word2vec. Были выделены наиболее распространенные n-граммы, связанные с COVID-19. Авторы предлагают оригинальную методику выявления тематических групп твитов и оценки их значимости, которую можно использовать не только для коротких сообщений в «Твиттере», но и для анализа текстовых документов. В результате исследования выделяются n-граммы различной длины, проводится их статистический анализ, формируются тематические группы, включающие наиболее релевантные n-граммы, и определяются их веса. Для оценки популярности тем предлагается численный показатель. Учитывается актуальная популярность тем и их динамика. Отмечается, что происходит эволюция тем обсуждений и образование новых терминов, связанных с пандемией.
The article analyzes Twitter messages to highlight the most relevant topics related to the spread of coronavirus in the world using the example of the Russian-language segment of Twitter. To analyze the proximity of words in the text and form terminological chains of words, the word2vec machine learning method was used. The most common n-grams associated with COVID-19 have been isolated. The authors propose an original method for identifying thematic groups of tweets and assessing their significance, which can be used not only for short messages on Twitter, but also for the analysis of text documents. As a result of the study, n-grams of various lengths are distinguished, their statistical analysis is carried out, thematic groups are formed, including the most relevant n-grams, and their weights are determined. To assess the popularity of topics, a numerical indicator is proposed. The current popularity of topics and their dynamics are taken into account. It is noted that there is an evolution of discussion topics and the formation of new terms related to the pandemic.
Machine learning algorithms for sentiment analysis
Authors: Бузин Д.С. , Азизов М.Т. 
Published: September 2022

Проводится комплексный анализ технологии машинного обучения. В ходе исследования разработаны алгоритмы глубокого обучения для анализа тональности текста и проведено сравнение их эффективности с другими классификаторами на основе алгоритмов машинного обучения.
The study provides a comprehensive analysis of machine learning technology. In the course of the study, deep learning algorithms were developed for analyzing the sentiment of the text and a comparison was made of their effectiveness with other classifiers based on machine learning algorithms.
Les relations entre le diffuseur public canadien CBC et les producteurs indépendants. Analyse d’une filière audiovisuelle en transformation
Authors: Bizimana Aimé-Jules , Kane Oumar 
Published: September 2022

L’essor du numérique bouleverse l’économie politique de la production indépendante. Cet article a pour objectif d’analyser les liens entre le réseau de langue anglaise du radiodiffuseur public canadien et la production indépendante dans le contexte des mutations technologiques et économiques. L’étude de nature qualitative recourt à l’analyse documentaire et à des entretiens semi-dirigés avec les responsables de la stratégie numérique du réseau public CBC et avec des producteurs indépendants. Le radiodiffuseur public s’adapte au numérique et les façons de faire des producteurs indépendants se modifient aussi dans un nouvel environnement audiovisuel caractérisé par un déséquilibre des rapports de force quant aux ententes commerciales avec la CBC et aux conditions de valorisation du contenu dans un contexte mondialisé.
Online health information seeking among patients attending primary care clinics in Bahrain: a cross-sectional study
Authors: Ali Aqeela A. , AliFardan Fatema A. , Aljamri Sahar Z. , Salman Wadeea M. , Mandeel Mohamed A. , Bahram Samya 
Published: September 2022

Background: Online health information seeking is prevalent among patients nowadays and this might influence the medical consultation outcome and affect the patient-doctor relationship. Objective was to determine the prevalence of online health information seeking behavior among primary care clinics attendees in Bahrain and the impact on patient-doctor relationship.Methods: Patients attending primary care clinics in Bahrain were asked to complete a previously adapted self-administered questionnaire that studied demographical data, frequency of online use in general and for health-related information and pattern of online health information seeking including reasons searched for and sources used. The logistic regression analysis done to explore respondent’s characteristics with health seeking behavior online.Results: Ninety-seven percent (97%) of the study population used the internet and (94.7%) had searched for online health information. The two main types of information sought were disease-related information (88.7%) and complementary and alternative medicine (55%). Fifty-three percent used reliable sources (i.e., Ministry of Health (43.3%), hospital websites (14.9%), medical encyclopedias (e.g., PubMed and Medline plus) (17.4%). Approximately (39.3%) use social networks to find information (including Facebook and Twitter). Convenience and usability were the main reasons (88.9%). Fifty-five percent (55%) asked or shared health information they found online with their doctor.Conclusions: Online health information seeking is highly prevalent in Bahrain among primary care clinic attendees. Sources were chosen mainly for their convenience, availability and being easily understood. A good number shared health information found online with their physicians. Physicians should be aware about patients’ online health seeking behavior and address that during consultation.
Monitoring of hepatitis B virus surface antigen escape mutations and concomitant nucleostide analog resistance mutations in patients with chronic hepatitis B
Authors: Deshkar Smita T. , Patil Niranjan B. , Lad Ashish A. , Papal Namrata S. , Sharan Swati S. 
Published: September 2022

Background: In hepatitis B virus (HBV), reverse transcriptase (RT) region of the polymerase P gene and surface S gene (HBsAg) are largely overlapped. Mutations in surface S gene may cause escape variants. In the present study, we aimed to study the prevalence and pattern of the typical HBsAg escape mutations and concomitant nucleos(t)ide analogue resistance mutation patterns in patients with chronic hepatitis B in Indian population.Methods: The present observational study was carried out from January 2021 to June 2022 with 156 known cases of hepatitis B infection. Hepatitis B viral load quantitation was done followed by HBV genotyping and drug resistance detection by PCR and sequencing.Results: Out of 156 cases of chronic hepatitis B, HBsAg escape mutations were found in 50 (32.05%) patients. Genotype D was predominant (90%). Median viral load was 4.43×105 copies/ml. Total 128 HBsAg escape mutations of 46 different patterns were observed with overall prevalence of 29.49% (46/156) in CHB infected patients. The most common substitutions were sP127T (16.67%), sA128V (14.74%), sR122K (5.13%), sY134N (3.85%), sK141R (2.56%), sS143L (2.56%) and sT126INST (1.92%). Concomitant RT mutations were detected in 20 (40%) patients. Total 68 (43.59%) RT mutations of 18 different mutation characteristics were found conferring possible or confirmed resistance to nucleos(t)ide analogues.Conclusions: The emergence of drugs resistant mutants with alteration in ‘aa’ determinant of the S protein is of some concern. The development of novel nucleos(t)ide analogues with a high barrier to resistance is warranted. National surveillance networks should be set up.
An in-vitro analysis of L-Carnitine mediated rescue of TNF-? induced apoptosis in mice oocytes
Authors: Sharma Mona , Rana Ranjana , Halder Ashutosh , Gupta Surabhi 
Published: September 2022

: Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine implicated in various physiological and pathological events. Carnitine is a quaternary amine which plays a significant role in fatty acid oxidation and is reported to produce antiapoptotic effects. Aim of this work was to study the effect of L-Carnitine (LC) on TNF-α induced apoptosis in mice oocytes. : Oocytes were isolated from super ovulated Swiss Albino mice and treated with different concentrations of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100ng/ml) and LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml). TUNEL Assay was done for the biochemical assessment of apoptosis.: Apoptotic indices with different doses of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100 ng/ml) were 28.5%, 71.4%, 100%, 42.8% respectively. The concentration of TNF-α that produced the highest apoptotic index was 10ng/ml. LC alone in different doses (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml) did not elicit any apoptotic signal. Further LC was added in different doses with 10ng/ml TNF-α to study the rate of apoptosis in mice oocytes. Apoptotic index with 10 ng/ml TNF-α and different doses of LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1 mg/ml) were 25%, 37.5%, 50%, 62.5% respectively. The concentration of LC that reduced the apoptotic index to the maximum was 0.1mg/ml.: Present study could demonstrate the anti-apoptotic effect of LC against apoptotic effects of TNF-α in mice oocytes. The study presents preliminary data suggesting a possible therapeutic role of LC in inflammatory etiologies such as ovarian failure.
Physiological and biochemical parameters of smokers and alcohol consuming adults from Terai region of Nepal using cross-sectional study
Authors: Jha Birendra Kumar , Sherpa Mingma Lhamu , Singh Jitendra Kumar , Dahal Binod Kumar , Gupta Chamma 
Published: September 2022

Non-communicable chronic diseases (NCD) are contributing 46% to the global diseases burden and account for 59% of annual death. Tobacco and alcohol consumptions are reported as major factors associated with growing burden of NCDs and account for 11.5% of global death with around 80% of these deaths are reported in low middle-income countries.Nepal, a low middle-income county, is also facing an increasing prevalence (31%) of NCDs with a significant prevalence of smoking (37.1%) and alcohol consumption (15%-57%). To explore the physiological and biochemical parameters of smoker and alcohol consuming subjects of Terai region of Nepal. We conducted a community based cross-sectional study during August to November 2019, 282 adult participants were selected from Terai region of Janakpur Zone, Nepal, After obtaining written consent and clinical examination, fasting venous blood was collected from study subjects and examined for triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and fasting blood sugar.We observed significantly increased triglycerides (p&#60;0.05), and waist circumference (p&#60;0.05) in current smoking and alcohol consuming subjects, however diastolic blood pressure was found to be significantly higher among alcohol consuming subjects only (p=0.05). We did not observe any significant correlation between fasting blood sugar, total-cholesterol and LDL-cholesterol among smoking or alcohol consuming subjects.Significantly increased triglycerides, waist circumference and diastolic blood pressure in smoking and alcohol consuming subjects likely suggest lack of public awareness and heath promotion activities in Teari region of Nepal and indicate an urgent public health awareness programs in this region to maintain quality of life.
A comparative study of serum ferritin and thyroid stimulating hormone (TSH) levels in hypothyroid and euthyroid subjects
Authors: Prabhu P S Sumitha , Cheriyan Sumina , Sulaiman Libna 
Published: September 2022

Thyroid hormones synthesized and released by the thyroid gland, have a vital role in regulating the metabolism of body. Synthesis of these thyroid hormones requires an iron containing enzyme Thyroid Peroxidase (TPO). Thus, iron inadequacy can affect the proper functioning of the TPO enzyme that further affect the thyroid hormone production. Serum ferritin, an index of iron store is present in almost all cells; however, it has been reported that an alteration in ferritin levels occurs in patients with thyroid disease. This study was conducted to determine serum ferritin and Thyroid Stimulating Hormone (TSH) levels in hypothyroid and euthyroid subjects and to compare the same.The retrospective study was carried out in Amrita Institute of Medical Sciences (AIMS), Kochi, which included 30 hypothyroid subjects as cases and 30 age and gender matched healthy controls. TSH, Thyroxine (T4) and serum ferritin levels of the study groups were collected and recorded.The mean TSH of hypothyroid patients was found to be higher (16.12±17.00) than that of euthyroid group (2.35± 1.08) whereas the mean value of T4 (1.01± 0.25) and ferritin (43.80 ± 75.44) were found to be reduced in patients with hypothyroidism compared to normal subjects. All the parameters were statistically significant with p value &#60;0.05.The present study showed that hypothyroid subjects had significantly lower serum ferritin concentration than euthyroid subjects. Thus, serum ferritin measurement could be useful for the evaluation of thyroid diseases.
Study of lipid profile and insulin resistance in polycystic ovarian syndrome
Authors: Patil Vasudha Deepak , Belwalkar Gajanan , Nagane Nitin , Dhonde Sushma 
Published: September 2022

Polycystic ovarian syndrome (PCOS) is the most common metabolic and endocrine disorder in women of reproductive age group. It is the first leading cause of infertility in females with incidence of 5-10%.Polycystic ovarian syndrome encloses a spectrum of clinical and metabolic diseases that are associated with cutaneous excess androgen status which includes acne resistant to treatment, hirsuitism, male or female pattern baldness, ovulatory and menstrual disturbances such as irregular bleeding, amenorrhea, oligomenorrhea, polycystic ovaries, obesity and insulin resistance.To study lipid profile and insulin resistance in polycystic ovarian syndrome women.The present study included 60 diagnosed PCOS women in the age group of 16-40 years. Lipid profile (TC, TG and HDL) was done on fully automatic Meril 400 biochemistry analyzer. LDLwas calculated from TC, TG and HDL cholesterol as per Friedewald calculation. Fasting plasma glucose done in semiautoanalyser and serum insulin is measured by CLAI. Insulin resistance (IR) was calculated by using HOMA model (HOMA IR).Deranged serum lipids in the present study was mainly in the form of decreased HDL levels. Serum TC, TG and LDL levels were within normal range in most of the cases. Insulin resistance was prevalent in 75% PCOS cases in the present study.The women with PCOS should be screened for lipid profile which can be helpful in assessing the risk of cardiovascular disease.
C-reactive protein to albumin ratio in atrial fibrillation
Authors: ABUŞ Sabri 
Published: September 2022

Objectives: Atrial fibrillation (AF) may cause thromboembolism and cardiac morbidity and mortality. Patients with cardiovascular diseases are at risk for developing AF. In this study, the relationship between inflammation markers and AF was examined.
Methods: Among 689 people followed up in the cardiology outpatient clinic for reasons such as hypertension, coronary artery disease, and rheumatic valve disease, 88 patients with AF and 601 patients without AF were compared. The blood parameters of the AF group were examined during the period when AF developed in the patients. Hemogram and biochemistry parameters of AF and non-AF groups were compared.
Results: C-reactive protein to albumin ratio (CAR), neutrophil count to albumin ratio, neutrophil count to lymphocyte count ratio, and monocyte count to lymphocyte count ratio were significantly higher in the AF group than in the non-AF group (p &lt; 0.001, p &lt; 0.001, p = 0.001, and p &lt; 0.001; respectively). According to the Receiver Operating Characteristics analysis, it was found that the CAR value of cut-off: 0.0533 could diagnose AF with 74% sensitivity (AUC: 0.789, CI 95%: 0.726-0.853, p &lt; 0.001). Albumin value of cut-off: 3.75 was found to be able to diagnose AF with 82% specificity (AUC: 0.772, CI 95%: 0.707-0.836, p &lt; 0.001).
Conclusions: AF is an arrhythmia that should be recognized early due to the complications it causes, and the CAR value can be used in the diagnosis of AF in individuals with cardiac disease.
EU’s Legal Framework on Personal Income Tax and Suggestions for Asean to Protect The Rights of Taxpayers
Authors: Doan Kien Trung 
Published: September 2022

The European Union (EU) has a complete and standard legal system, which is always the object of research and evaluation to learn for many countries. The EU comprises countries with an appropriate personal income tax system to ensure human rights. To ensure equality and human rights, and development in every member state, the EU seeks to harmonise personal income tax law, an area primarily of national jurisdiction. This article aims to study and evaluate some basic regulations that the EU has issued to create compatibility of the personal income tax law of the member states, better ensure human rights and promote the development of the Union. Based on the experiences of the EU, the article analyses some implications for the harmonisation of personal income tax law within the ASEAN from the perspective of international private law.
Keywords: Personal Income Tax, Legal Harmonisation, EU, ASEAN
Ensuring the Rights of Vulnerable Groups in the Legislative Process in Vietnam
Authors: Doan Uyen To , Chu Hung Manh 
Published: September 2022

In recent years, Vietnam has actively and vigorously developed and strengthened law enforcement and facilitated access to the law to protect human rights and legitimate interests. After formulating the Judicial Reform Strategy and implementing the law, the State has created favourable conditions for vulnerable groups to participate in Vietnam's political, social, economic, and cultural life. However, it still faces challenges in ensuring and facilitating access to the law and raising legal awareness. In particular, women, ethnic minorities, people with disabilities, and children are the most vulnerable groups. Therefore, this article focuses on the guarantee of the rights of vulnerable groups in the process of law-making in Vietnam today to unveil difficulties and limitations; on that basis, it makes proposals for ensuring the rights of vulnerable groups in the legislative process in the coming time.
Keywords: Human Rights, Rights of Vulnerable Groups, Law-making
N-Acetylcysteine (NAC) and its Immunomodulatory Properties
Authors: Tieu Sophie , Karrow Niel , Mallard Bonnie , Bridle Byram , Charch Armen , Wagter-Lesperance Lauri 
Published: September 2022

Despite the increasing interest and use of NAC over the decades, there remains much debate surrounding NAC’s mechanisms of action. It was widely believed that NAC exerts its antioxidant and cytoprotective properties through its ability to act as a scavenger of reactive oxygen species, a precursor for glutathione biosynthesis, and a disulfide reductant. However, these three major narratives are only applicable under specific circumstances and cannot explain NAC’s actions in a more general context. A newly emerging alternative mechanism of action of NAC involving hydrogen sulfide and sulfane sulfur species may serve to provide an explanation of NAC’s effects in a more generalized context. Part II of this review will provide an overview of NAC’s mechanisms of molecular action.
Synthesis and Evaluation of Naphthalene Derivatives as Potent STAT3 inhibitors and Agents Against Triple-Negative Breast Cancer Growth and Metastasis
Authors: Yang Zhengyan , Xu Hongyun , Yang Yupo , Duan Chaoqun , Zhang Pai , Wang Yang , Fu Kai , Shen Yonghong , Xu Marvin Xuejun 
Published: September 2022

Abstract
Purpose
Triple-negative breast cancer (TNBC) represents the worst prognostic subtype of breast cancer and lacks targeted therapeutic drugs. Signal transducer and activator of transcription 3 (STAT3) is overexpressed and constitutively activated in TNBCs and associated with poor patient outcomes. However, no agents targeting STAT3 have been successfully developed and marketed. Selective Estrogen Receptor Modulators (SERMs) have been reported as potential inhibitors of the IL-6/STAT3 signaling pathway. Naphthalene compounds have good pharmacological activity and significant anti-cancer activity. In this study, we synthesized a new series of naphthalene derivatives with the general structure of SERM and evaluated their effects on TNBC and STAT3 signals.
Methods
A new series of compounds based on the scaffold of SERMs and an amino group were designed and screened based on the structure-activity relationship by MTT assay. The binding activity of SMY002 to STAT3 was predicted and validated by docking and SPR. The STAT3 signaling target and anti-cancer effects of SMY002 were evaluated with three TNBC cell lines and the mice transplanted tumor model.
Results
Among the compounds, SMY002 displayed the most potent activity, which could directly interact with STAT3 SH2-domain, and strongly inhibit the phosphorylation, dimerization, nuclear distribution, transcriptional activity, and target genes expression of STAT3. Furthermore, SMY002 markedly suppressed migration, invasion, survival, growth, and metastasis of TNBC cells in vitro and in vivo via down-regulating the expression of Cyclin D1 and MMP9.
Conclusions
SMY002 can significantly inhibit the growth and metastasis of TNBC cells by targeting the STAT3 signal.
WNK1 enforces macrophage lineage fidelity
Authors: Perry Justin , Trzeciak Alissa , Rojas Waleska Saitz , Krebs Adam , Zago Giulia , Wang Ya-Ting , Wang Zhaoquan , Saavedra Pedro , Xie Jian , Huang Chou-Long , Overholtzer Michael , Glickman Michael , Parkhurst Christopher , Vierbuchen Thomas , Lucas Christopher 
Published: September 2022

Abstract
The appropriate development of myeloid progenitors into macrophages, the body’s professional phagocyte, is essential for organismal development, especially in mammals1. This dependence is exemplified by the observation that loss-of-function mutation in colony stimulating factor 1 receptor (CSF1R) results in multiple tissue abnormalities including osteopetrosis2. Despite this importance, little is known about the molecular and cell biological regulation of macrophage development. Here, we report the surprising finding that the chloride-sensing kinase With-no-lysine 1 (WNK1) is required for embryonic development of tissue-resident macrophages (TRMs). Myeloid-specific deletion of Wnk1 caused a dramatic loss of TRMs and subsequently disrupted organ development, induced systemic neutrophilia, and resulted in mortality between 3 and 4 weeks of age. Specifically, we observed that WNK1 absence stalled macrophage differentiation at the myeloid multipotent progenitor (MPP) stage, instead skewing MPP differentiation towards granulopoiesis. Mechanistically, the cognate CSF1R cytokine, macrophage-colony stimulating factor (M-CSF), triggers macropinocytosis in myeloid progenitors, which in turn induces phosphorylation of WNK1. Importantly, macropinocytosis by myeloid progenitors increases cytosolic chloride, which is directly sensed by WNK1. Perturbing chloride flux during macropinocytosis, inhibiting WNK1 chloride-sensing, and blocking macropinocytosis each skew progenitor differentiation from macrophage lineage to granulocyte lineage. Thus, we have uncovered a novel mechanism that links a cell biological process to a molecular circuit whereby WNK1 chloride-sensing and chloride flux act downstream of M-CSF-induced macropinocytosis by multipotent progenitors to ensure macrophage lineage fidelity.