bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECIENCY AND SAFETY OF THE VETERINARY MEDICINAL PRODUCT VETASEPTOL IN THE TREATMENT OF PIGS SUFFERING FROM ACUTE RESPIRATORY DISEASE OF BACTERIAL ETIOLOGY
Authors: Lisova N. , Shkodyak N. , Sobodosh O. , Zhyla M. , Maksymovych O. , Myhalyuk O. , Stetsko T. , Ostrovska L. 
Published: December 2022

The article presents the results of clinical trials on pigs of the veterinary medicinal product Vetaseptol (powder for oral use), manufactured by “Ukrvetrompostach LLC”. The drug was used orally with feed for the treatment of acute respiratory infection in 2-month-old piglets in the dosage recommended by the manufacturer. Before the experiment, microbiological studies were conducted on selection and identification of microorganisms, pathogens of respiratory infection in pigs, and establishing of their sensitivity to the active substances of the drug (oxytetracycline and erythromycin). During the experiment, constant observation of the clinical condition and physiological parameters of the body of the experimental animals were performed. Evaluation of hematological and biochemical indicators was carried out according to recognized methods. The therapeutic efficiency was compared with the data obtained before the treatment and after using the comparator drug. On the basis of obtained data and their statistical analysis, conclusions about the effeciency of Vetaseptol in the treatment of pigs, suffering from streptococcosis, and its effect on their organism were made.
According to the evaluation of the animal’s clinical condition and the results of laboratory tests obtained, it was established that the tolerability of the studied drug for the treatment of respiratory infection of young pigs was good. During the experimental period and two weeks after the use of the drugs, no side effects were detected and no changes in the behavior of the piglets were observed. The therapeutic effectiveness of the test drug was 100%, and the recovery time was almost 5 days. A comparative analysis of piglet’s hematological indicators showed a reliable decrease of monocytes number in the animal’s leukogram after antibiotic therapy. The normalization of the piglet’s leukogram indicated the termination of inflammatory processes and the improvement of the physiological state of animals. The serum biochemical profile of experimental animals hasn’t changed significantly. Laboratory studies did not reveal hemo- and hepatotoxic effects of the antimicrobial drug.
DEVELOPMENT OF METHODS FOR QUANTITATIVE DETERMINATION OF MEBENDAZOLE AND ITS METABOLITES IN BIOLOGICAL TISSUES USING HPLC/ DAD
Authors: Melikyan S. , Biront N. , Pazderska O. , Mys’ko G. , Yanovych D. 
Published: December 2022

This manuscript presents the results of developed method is intended for clinical and pharmaceutical studies of veterinary drugs based on the active substances mebendazole and its main metabolites: mebendazole amin and mebendazole hydroxide in sheep muscles and liver. Tissue samples were made alkaline with sodium carbonate, extracted twice with acetonitrile and degreased with hexane. The extracts are further purified using a series of liquid-liquid extraction and solid phase extraction. After concentration and drying, the dry residue was recovered in the mobile phase. Separation was performed on an inverted phase Kinetex EVO С18 column using acetonitrile and phosphate buffer as the mobile phase. The gradient mode of eluents was used during 10 min at a flow rate of 1,5 ml/min. The peak retention time of a mebendazole is 3,4 min, mebendazole hydroxide is 4,1 min, and the retention time of mebendazole amin peak is 6,1 min. The specificity of the analytical method was checked by comparing the chromatographic separation of a sample of muscle tissue and liver enriched with a standard solution of a mixture of mebendazole and its main metabolites at the level of MDR and a sample of muscle tissue and liver placebo. The procedure of sample preparation of fortified tissues to construct calibration graphs is described in the manuscript. The validation parameters of the method “recovery” and “coefficient of variation” were considered in accordance with the criteria of Council Directive 2002/657/EC. The mean recovery from fortified muscle tissue in the range of 40.0-60.0 μg/kg mebendazole and its metabolites was 98 %. The average extraction of the studied analytes from the loaded liver in the range of 200.0 - 600.0 μg/kg was 100 %. The average coefficient of variation for each compound was ≤ 10 %.
The method is linear in the concentration range of 5 – 100.0 μg/kg of each analyte in muscles and 50,0 – 800,0 μg/kg in liver. The results obtained in the study of the linearity of this technique were used to estimate the correctness and convergence. The accuracy of the measurements was evaluated by examining the known amounts of analytes added to the control muscle tissue. Recovery data are acceptable because they are within ± 10% of the target value. The method has sufficient convergence (accuracy). The evaluation of the intermediate accuracy of mebendazole and its main metabolites was assessed on three different days of analysis. The average CV for each compound was <10 %. Selectivity and high sensitivity are the main advantages of the developed technique. The developed HPLC/DMD method can be used to study the deficiency of mebendazole and its metabolites.
MORPHOLOGICAL INDICATORS OF BLOOD IN CATS WITH CALICIVIROSIS
Authors: Radzіkhovskyі N. , Sachuk R. , Sokulsky I. , Dyshkant О. , Tolokevich O. 
Published: December 2022

In recent years, there has been a massive trend in Ukraine to keep cats, which has inevitably led to an increase in the incidence of their diseases. In the general pathology of cats, viral diseases occupy a leading place, and of particular concern is calicivirosis, which is caused by a virus capable of high mutation rates and can cause atypical course with nonspecific manifestations of clinical signs. Therefore, given the urgency of this issue, the result of our research is to clarify, supplement and summarize data on hematological and biochemical parameters of blood and erythrocytopoiesis in calicivirosis in cats, because blood is a sensitive and informative indicator of the body, responds quickly to changes as exogenous. and endogenous factors. The research was conducted in veterinary clinics of Zhytomyr and Kyiv, on purebred and outbred cats (n = 18). Diagnostic studies to confirm feline calicevirus were performed using rapid tests Ag Test (FCV Ag), Quicking Biotech Co., Ltd. and ELISA and PCR for the presence of calicivirus antigen on the basis of a private veterinary laboratory LLC "Bald" in Kiev.
Comprehensive studies have shown that cats with calicivirosis (18) are characterized by changes in morphological and biochemical composition of blood. Deviations from physiological limits were found, namely erythrocytopenia P≤0.05, thrombocytosis P≤0.05, leukocytosis P≤0.05, monocytosis P≤0.01, increase in ESR P≤0.001 and lymphocytopenia P≤0.05, for biochemical ones it is a significant increase in the concentration of globulin P≤0.001, creatinine P≤0.001, urea P≤0.05 hyperenzymemia α-amylase P≤0.001, and ALT P≤0.05. As a result of experimental research of morphological indicators of blood the difficult pathogenesis of a disease with multiorgan insufficiency is established.
DOXYCYCLINE EFFICIENCY AND SAFETY IN THE TREATMENT OF ACUTE INTESTINAL INFECTIONS OF BACTERIAL ETIOLOGY IN BROILER CHICKENS
Authors: Shkodyak N. , Stetsko T. , Pyatnychko O. , Sobodosh O. , Lisova N. , Ostrovska L. , Balyan O. 
Published: December 2022

Doxycycline is a bacteriostatic antibiotic from the group of tetracyclines, a semi-synthetic derivative of chloretracycline. It is a broad-spectrum antibiotic that is active in gram- positive and gram- negative bacteria, including some anaerobes. Therefore, the use of doxycycline drugs is relevant to solve the problem of treatment and control of mono- and polyinfections, which are caused by doxycycline sensitive and other antibiotics resistant to other antibiotics.
The article presents the results of clinical studies of a new veterinary drug Doxal (water-soluble powder for oral administration), production of PJSC “Technologist” (Ukraine), an active pharmaceutical ingredient of which is doxycycline, in the treatment of acute intestinal disease in broiler chickens.
A high level of therapeutic efficacy and safety of the Doxal studied drug in the treatment of chickens 25 daily age with colibacteriose-claspidiosis infection was established.
The diagnosis was made on the basis of anamnestic data, a clinical picture of the disease, the results of pathoanatomical section and bacteriological examination. Microorganisms – pathogens of infection, their level of sensitivity to doxycycline were selected and identified. Therapeutic efficiency of the tested drug was not inferior to the drug-comparison of Doxatib®, production of KRKA DD Novo-Mesto (Slovenia), similar in dosage form and the content of the active substance.
According to the results of laboratory tests, a positive effect of Doxal on the morpho-functional state of the body of chickens in the treatment of acute colibacteriosis-claspidiosis infection was revealed, which is confirmed by normalization with a high percentage of the reliability of morphological and biochemical blood indicators to the values of clinically healthy bird.
Comparative clinical studies have confirmed that Doxal drug is effective chemotherapeutic agent for the treatment of bacterial infections in chickens caused by microorganisms sensitive to doxycycline, and is analogous to Doxatib® by it’s action.
Hopf Structures in the Representation Theory of Direct Products
Authors: Aliniaeifard Farid , Thiem Nathaniel 
Published: December 2022

Combinatorial Hopf algebras give a linear algebraic structure to infinite families of combinatorial objects, a technique further enriched by the categorification of these structures via the representation theory of families of algebras. This paper examines a fundamental construction in group theory, the direct product, and how it can be used to build representation theoretic Hopf algebras out of towers of groups. A key special case gives us the noncommutative symmetric functions NSym, but there are many things that we can say for the general Hopf algebras, including the structure of their character groups and a formula for the antipode.
PERAN LEMBAGA KEUANGAN MIKRO DAN TENAGA KERJA TERHADAP PERTUMBUHAN EKONOMI
Authors: Indarti Dwi , Maulidiya Erlina , Simorangkir Christien , Saraswati Birgitta Dian 
Published: December 2022

Economic growth is a measure of the welfare of the Indonesian people. Over time, the factors that affect economic growth are growing. The emergence of Microfinance Institutions (MFIs) has its own impact on Indonesia's economic growth. This study aims to determine the effect of Microfinance Institutions on economic growth in Indonesia. By using the Random Effect Model (REM) panel data regression method covering 21 provinces in Indonesia in the 2019-2020 period, this study shows that, only the Labor variable is proven to have an effect on economic growth in Indonesia. While the variables for the number of MFIs and the amount of MSME loan funds have not been proven to have an effect on economic growth in Indonesia. This indicates that the human resource factor as a form of human capital is the main factor driving economic growth in Indonesia. So that the policy implication of this research is to encourage economic growth a policy to improve the quality of human resources is needed.
Keywords: Economic Growth, Total Microfinance, Labor, REM
KUALITAS PELAYANAN KARTU TANDA PENDUDUK ELEKTRONIK (e-KTP) PADA DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN ENDE
Authors: Age Karolus , Tanusi Gabriel 
Published: December 2022

Excellent service provided by service officers in the field of population registration, especially e-KTP loading, greatly affects the quality of service perceived by the community. Making e-KTP which take 2-4 weeks, lack of friendliness of employees is providing services, service provided are too bureaucratic, the numbers of officers who handle the e-KTP recording process is not comparable to the people who take care of making e-KTP are problems faced in managing the e-KTP. This study aims to determine the value of the community satisfaction index in getting public services at the office of population and civil registration in ende regency, especialy the process of making e-KTP. The population in this study amounted to 9.811 people with a total sampel of 99 people. Date collection techniques using questionnaires, interviews and documentation. The dat a of analysis technique uses an analysis of the community satisfaction index which is calculated using the weighted average value of each service element. The result of the study show that the community satisfaction index in obtaining e-KTP making services at the ende regency popilation and civil registration office uses 12 elements or assessment indicators coverted to 37,50 and is in the category of poor service quality, while the average value of the community satisfaction indeks studied based on the characteristics of the respondents is 1,39 and is the category of poor service quality
HUBUNGAN USIA DENGAN JENIS TUMOR OVARIUM DI RUMAH SAKIT BETHESDA YOGYAKARTA TAHUN 2019
Authors: Nosakaytu Grasyella Iga , Jayadi Tejo , Putra Eduardus , Kusumosih Theresia 
Published: December 2022

Data WHO tahun 2014 mencatat bahwa kanker ovarium menempati posisi insidensi keempat terbanyak pada wanita setelah kanker serviks, kanker payudara, dan kanker korpus uteri. Data penelitian di RS Dharmais Jakarta tahun 2019 menyatakan bahwa kanker ovarium menempati posisi ketiga (7,84%) penyebab kematian akibat kanker pada wanita setelah kanker payudara dan kanker serviks. Berdasarkan data yang diperoleh jenis tumor ovarium yang bervariasi dan angka kematian yang disebabkan oleh tumor ovarium meningkat setiap tahun sehingga peneliti ingin mendapatkan data banding penderita tumor ovarium di RS Bethesda Yogyakarta dan gambaran kejadian berdasarkan usia, jenis histopatologi tumor jinak ovarium, dan jenis histopatologi tumor ganas ovarium. Penelitian ini bertujuan untuk mengetahui hubungan antara usia dengan berbagai jenis histopatologi tumor jinak dan tumor ganas ovarium di RS Bethesda Yogyakarta. Metode yang digunakan adalah deskripsi analitik dengan desain penelitian cross sectional. Dari 122 data yang diperoleh, ditemukan jenis histopatologi tumor jinak ovarium sebesar 51,6% (63 pasien) dan jenis histopatologi tumor ganas ovarium sebesar 48,4% (59 pasien). Hasil yang didapatkan dari uji Chi-Square terdapat hubungan antara usia dengan jenis tumor ovarium ditunjukkan dari output spss <0,05 yang bermakna secara signifikan dengan (OR: 6,176; 95% CI: 2,526-15,101). Data rekam medis RS Bethesda Yogyakarta pada periode 2019 menunjukkan bahwa terdapat hubungan yang signifikan antara usia dan jenis histopatologi tumor ovarium.
Spectroscopic Confirmation of a Population of Isolated, Intermediate-mass Young Stellar Objects
Authors: Kuhn Michael A. , Saber Ramzi , Povich Matthew S. , de Souza Rafael S. , Krone-Martins Alberto , Ishida Emille E. O. , Zucker Catherine , Benjamin Robert A. , Hillenbrand Lynne A. , Castro-Ginard Alfred , Zhou Xingyu ,   For the COIN collaboration
Published: December 2022

Abstract
Wide-field searches for young stellar objects (YSOs) can place useful constraints on the prevalence of clustered versus distributed star formation. The Spitzer/IRAC Candidate YSO (SPICY) catalog is one of the largest compilations of such objects (∼120,000 candidates in the Galactic midplane). Many SPICY candidates are spatially clustered, but, perhaps surprisingly, approximately half the candidates appear spatially distributed. To better characterize this unexpected population and confirm its nature, we obtained Palomar/DBSP spectroscopy for 26 of the optically bright (G < 15 mag) “isolated” YSO candidates. We confirm the YSO classifications of all 26 sources based on their positions on the Hertzsprung–Russell diagram, H and Ca ii line emission from over half the sample, and robust detection of infrared excesses. This implies a contamination rate of <10% for SPICY stars that meet our optical selection criteria. Spectral types range from B4 to K3, with A-type stars being the most common. Spectral energy distributions, diffuse interstellar bands, and Galactic extinction maps indicate moderate-to-high extinction. Stellar masses range from ∼1 to 7 M
⊙, and the estimated accretion rates, ranging from 3 × 10−8 to 3 × 10−7
M
⊙ yr−1, are typical for YSOs in this mass range. The 3D spatial distribution of these stars, based on Gaia astrometry, reveals that the “isolated” YSOs are not evenly distributed in the Solar neighborhood but are concentrated in kiloparsec-scale dusty Galactic structures that also contain the majority of the SPICY YSO clusters. Thus, the processes that produce large Galactic star-forming structures may yield nearly as many distributed as clustered YSOs.
VERTICO. IV. Environmental Effects on the Gas Distribution and Star Formation Efficiency of Virgo Cluster Spirals
Authors: Villanueva Vicente , Bolatto Alberto D. , Vogel Stuart , Brown Tobias , Wilson Christine D. , Zabel Nikki , Ellison Sara , Stevens Adam R. H. , Jiménez Donaire María Jesús , Spekkens Kristine , Tharp Mallory , Davis Timothy A. , Parker Laura C. , Roberts Ian D. , Basra Dhruv , Boselli Alessandro , Catinella Barbara , Chung Aeree , Cortese Luca , Lee Bumhyun , Watts Adam 
Published: December 2022

Abstract
We measure the molecular-to-atomic gas ratio, R
mol, and the star formation rate (SFR) per unit molecular gas mass, SFEmol, in 38 nearby galaxies selected from the Virgo Environment Traced in CO (VERTICO) survey. We stack ALMA 12CO (J = 2−1) spectra coherently using H i velocities from the VIVA survey to detect faint CO emission out to galactocentric radii r
gal ∼ 1.2 r
25. We determine the scale lengths for the molecular and stellar components, finding a ∼3:5 relation compared to ∼1:1 in field galaxies, indicating that the CO emission is more centrally concentrated than the stars. We compute R
mol as a function of different physical quantities. While the spatially resolved R
mol on average decreases with increasing radius, we find that the mean molecular-to-atomic gas ratio within the stellar effective radius R

e
, R
mol(r < R

e
), shows a systematic increase with the level of H i, truncation and/or asymmetry (HI perturbation). Analysis of the molecular- and the atomic-to-stellar mass ratios within R

e
,

R
⋆
mol

(
r
<

R
e

)

and

R
⋆
atom

(
r
<

R
e

)

, shows that VERTICO galaxies have increasingly lower

R
⋆
atom

(
r
<

R
e

)

for larger levels of HI perturbation (compared to field galaxies matched in stellar mass), but no significant change in

R

⋆

m

o

l

(
r
<

R
e

)

. We also measure a clear systematic decrease of the SFEmol within R

e
, SFEmol(r < Re
), with increasingly perturbed H i. Therefore, compared to field galaxies from the field, VERTICO galaxies are more compact in CO emission in relation to their stellar distribution, but increasingly perturbed atomic gas increases their R
mol and decreases the efficiency with which their molecular gas forms stars.
Les tragédies de l’exécution chez La Calprenède : ambiguïté judiciaire et esthétique aristotélicienne
Authors: Ding Ruoting 
Published: December 2022

La Calprenède s’intéresse particulièrement au sujet de l’exécution. Parmi les six tragédies publiées, quatre se terminent par une mise à mort. Dans ces pièces, le dramaturge interroge d’une part la culpabilité ambiguë de l’accusé et d’autre part la position du roi-juge dont la considération dépasse le cadre strictement juridique. Il combine le modèle aristotélicien dont l’enjeu réside dans la notion de faute et celui de l’innocence persécutée qui assimile les condamnés aux victimes du machiavélisme d’État. Ainsi, la mort du héros, ni entièrement méritée, ni entièrement imméritée, devient le vecteur de l’émotion tragique sur deux plans : d’un côté, la punition, résultant d’une faute mais présentant un caractère excessif, suscite la compassion du public ; de l’autre, le « bourreau » éprouve une douleur qui éveille également la pitié du spectateur. Cette dramaturgie de l’équivocité s’enrichit enfin par certains éléments empruntés au théâtre de dévotion.
Mœurs et coutumes japonaises au prisme des premiers observateurs européens (1543-1585)
Authors: Thomas Jérôme 
Published: December 2022

L’histoire du Japon s’est tout d’abord définie comme isolée, un pays aux portes fermées par des chaînes (sakoku). Il aurait existé un corps insulaire et même un caractère national déterminé par un espace physique spécifique, ce qui aurait induit des mentalités et des perceptions originales. Ce « corps japonais » selon le mot de Marc Kober serait marqué par le regard européen et une curiosité condescendante. Il se condense en certains traits jugés typiques et cette stéréotypie identifie une culture à un corps. La confrontation physique directe ou imaginaire fit naître des représentations tout au long du XVIe siècle. À travers les sources et commentaires sur les premiers contacts entre Portugais et Japonais, de 1543, l’ouvrage fondamental de Fróis sur Européens et Japonais. Traité sur les contradictions et différences de mœurs (1585), les écrits de François Xavier et les lettres jésuites, nous tenterons de comprendre et d’analyser les mœurs et coutumes japonaises au prisme du regard européen face à cette nouvelle altérité.
Performing Contestation
Authors: Vidal Melanie Sampayo 
Published: December 2022

This article explores the potential and limits of the popular satire theatre Kotéba in transporting critical narratives into the Malian public sphere. It investigates how Kotéba can be perceived as a means of contestation. Through the accounts of two cultural agents who were actively implicated in creating plays and censorship-processes during the Moussa Traoré regime (1968-1991), the author traces Kotéba’s development and social function to discuss the interconnection of theatre, narrative and contestation. The focus on narrated memories favors a backstage perspective, allowing insight into the otherwise hidden processes which make “performing contestation” possible.
Entre patrimonialisation et innovation sociale, le collectif comme opérateur territorial de la transition : le cas du collectif de Chirols en Ardèche
Authors: Vigne Flore , Landel Pierre-Antoine 
Published: December 2022

Le présent article résulte d’un travail de recherche sur le devenir du patrimoine industriel dans les Monts d’Ardèche (Vigné, 2021). À partir d’une analyse d’un corpus de près de 700 sites, trois lieux sont identifiés car les porteurs de projet y sont explicitement engagés dans le développement d’innovations sociales. Sur l’un de ces sites, le moulinage de Chirols, la description des patrimoines mobilisés, des acteurs engagés et de leurs modes d’organisation, ainsi que des projets développés, interrogent le statut des collectifs impliqués en tant « qu’opérateur territorial de la transition ». En parallèle à une discussion sur les modalités d’ancrage territorial de ces innovations, l’article vérifie la capacité du porteur de projet, le Collectif du moulinage de Chirols à mettre en place des intermédiations entre des acteurs différenciés, entre des échelles d’intervention mais aussi entre l’histoire longue du territoire et l’action contemporaine. Ce faisant, il met en discussion l’hypothèse d’une patrimonialisation transformative de la trajectoire des territoires, qui mérite maintenant d’être confrontée à d’autres terrains d’étude.