bluuebunny/crossref_metadata_2025_split huggingface dataset:
As medidas governamentais de prevenção ao suicídio no Brasil têm sido efetivas?
Authors: Lopes Mauro Marques , Lucas Bernardes Frois Jean , Lima Augusto de Morais , Gonçalves Lucas Tadeu Washington , Ribeiro Samuel Melo , Vale Leonardo Turquette Lellis do , Teles Marina Pacheco , Andrade Isabela Vasconcelos Ramos , Negris Thaygor de Matos , Cunha Thaier Serqueira 
Published: August 2022

Introdução: O suicídio é um problema de saúde pública global que tem aumentando de forma gradual nos últimos 10 anos. O Brasil ocupa a oitava posição no ranking mundial com mais casos de suicídios. O objetivo do estudo é analisar a efetividade das medidas governamentais de prevenção ao suicídio no Brasil. Metodologia: Trata-se de uma revisão integrativa da literatura realizada através das bases de dados Scielo, Pubmed, BVS, CINAHL e UpToDate contendo publicações entre 2017 a 2022. Resultados: Entre 2010 e 2019, foi observado um aumento de 43% no número anual de suicídios no Brasil, totalizando 112.230 mortes. Esse dado reflete a ineficácia das políticas públicas no combate ao suicídio. Associado à ineficiência dos planos de ação, a falta de treinamento específico dos profissionais de saúde na atenção básica prejudica a identificação e tratamento das doenças correlacionadas. Conclusão: As políticas públicas para a prevenção do suicídio devem ser mais precisas e efetivas, para que sua prática alcance todos os cidadãos. Estudos apontam falta de controle destes índices e o aumento progressivo de casos de suicídio. Intervenções relacionadas as primeiras manifestações de ideação suicida tem potencial promissor como medidas efetivas e devem ser estudadas.
A importância da implantação do acolhimento na atenção primária à saúde: revisão integrativa
Authors: Ribeiro Ana Paula Maria , Frisanco Fernanda Menegatti , Barbieri Melina Renata Blascke , De Lima Valéria Beatriz , Jacob Lia Maristela da Silva , Maciel Júnior Marcos 
Published: August 2022

Objective: to identify through the integrative review the importance of the implementation of the reception in Primary Health Care providing information about this attitude in the light of the published literature. Methodology: This is an integrative review of the literature, whose data were collected from secondary sources, through a bibliographic survey of scientific studies in Brazil, from 2017 to 2021, in three databases: VHL (Medical Literature Analysis and Retrieval System Online), Pubmed (U.S.National Library of Medicine) and Web of Science; the main question of the study was: What were the impacts on the quality of Primary Health Care with the implementation of reception in health services in Brazil in the last five years? Results: The search resulted in 160 articles, after reflective and critical reading of the abstracts, 15 articles were selected that met the objectives and the guide question, after the full reading of the articles was performed. Conclusion: Welcoming is a method designed to collaborate with the qualification of health issues, in a way that allows the user access to a fair and comprehensive care, through multiprofessionality and intersectoriality. It is a tool capable of enabling the SUS to effectiveness its constitutional principles. In addition, the study showed that welcoming promotes the connection of trust and commitment of users with the team and services, being a fundamental action for the humanization of the SUS and depends solely on the professionals inserted in the Primary Care network.
Nível de estresse de pais adolescentes de recém-nascidos internados em uma Unidade de Terapia Intensiva Neonatal
Authors: Lima Gabriela Colombi de , Sehnem Graciela Dutra , Cogo Silvana Bastos , Kleinubing Raquel Einloft , Garzão Bruna Oliveira Ungaratti , Selli Tainá , Marquesin Mylena Wichinheski 
Published: August 2022

Objetivo: analisar o nível de estresse e identificar os fatores mais estressantes para os pais adolescentes de recém-nascidos internados em uma Unidade Terapia Intensiva Neonatal. Método: estudo quantitativo e transversal, com mães/pais adolescentes de recém-nascidos hospitalizados, com faixa etária entre 10 e 19 anos, no período de maio a outubro de 2021. Para a coleta de dados utilizou-se a versão brasileira da Parental Stress Scale: Neonatal Intensive Care Unit. A análise foi realizada por meio do programa estatístico Software Statistical Package for the Social Sciences, com medidas de tendência central e de dispersão. Resultados: a pesquisa contou com nove participantes, a subescala “Alteração no papel de mãe/pai” obteve o maior nível de estresse (média=3,85), seguido de “Aparência e comportamento do bebê” (média=2,63) e “Imagens e sons” (média=1,82). Conclusão: a inserção dos pais nos cuidados com o filho na Unidade Terapia Intensiva Neonatal é uma prática que deve ser estimulada, pois proporcionará o fortalecimento do vínculo e amenizará o estresse vivenciado durante a internação.
Caatinga: barn of antioxidant and nutraceutical bio-actives
Authors: Diniz Katharina  Marques , Santos Milena Maia Dantas dos , Barbosa Julyanne Maria de Lima , Borges Yan Wagner Brandão , Silva Wilka Maria do Nascimento , Veras Bruno de Oliveira , Silva Márcia Vanusa da , Correia Maria Tereza dos Santo 
Published: August 2022

The Caatinga, of Brazilian exclusivity, is compound by adapted plants for the climate-specific conditions present in this region. The natural resources in this phytogeography domain are used for local communities as foods source, regional economics develops, and traditional medicine. Folk medicine is applied as a local tradition through the fraction of the plants, such as roots, leaves, and fruits, to treat inflammation, tumor, metabolic or degenerative diseases. Although the technological pharmaceutical industrial process shows exponential development in benefits for human health, the search for new treatments, naturals, and alternatives linked with the significant consciousness of the populations some knowledge about folk medicine and their natural compounds are not vast. In this way, the present review aimed to realize the systematic research considering 26 species endemics in Caatinga and their most significant biological potential. As a result, it was observed that have more studies with the antioxidative and immunomodulatory activities. The previous knowledge shows the relation between the accumulation of reactive oxygen species (ROS) and the development of different immunological diseases. With this review, we propose to contribute to the biotechnological potential of the Caatinga for science health.
Lavagem das mãos: profissionais de saúde, práticas e narrativas
Authors: Gama Junior Walter Oliveira , Monteiro Claudia Barbastefano , Miranda Rita de Cássia Mendonça de , Rêgo Adriana Sousa , Chagas Maria Raimundo , Loyola Cristina Maria Douat 
Published: August 2022

Este estudo objetivou analisar as práticas (observação participante) e narrativas (entrevistas) dos profissionais de saúde e administrativos de um hospital, diante da necessidade de higienização das mãos no ambiente hospitalar. Trata-se de um estudo qualitativo, descritivo, exploratório de natureza analítica, utilizando-se a análise de conteúdo para o material empírico e a teoria das representações sociais (TRS), realizada com vinte e um profissionais (médicos, enfermeiros, técnicos de enfermagem, fisioterapeutas, maqueiros e administrativos das unidades de saúde). Para a coleta de dados, utilizou-se 60 horas de observação participante e vinte e uma entrevistas. Os resultados demonstraram que duas categorias: ato de higienização das mãos – percepção do sujo e do limpo e as necessidades de higienização das mãos no ambiente de trabalho. O estudo demonstrou que a higienização das mãos parece um hábito de difícil modificação e este estudo mostra que a maioria dos profissionais de saúde higieniza as mãos de acordo com as suas necessidades, ou seja, quando eles têm a percepção de que as mãos estão realmente sujas ou em ocasiões que eles tiveram contato com o sujo, deixando de fazê-la nos momentos recomendados. Apesar das evidências de sua eficácia, a conformidade com a higiene das mãos é bastante baixa, como foi verificado na observação participante, isso pode ser devido à natureza da higienização das mãos ser uma ação impulsionada pelo comportamento social.
Polimorfismos no gene IL17A não influenciam nas manifestações clínicas, laboratoriais e radiológicas da tuberculose
Authors: Felício Suelen Aparecida , Rosa Ualter Guilherme Cipriano , Matarazo João Guilherme Araujo , Aguiar Amanda Aparecida Silva de , Mazaro Paulo José Mascarenhas , Santos Elaine Cristina Negri , Peresi-Lordelo Eliana 
Published: August 2022

Alguns polimorfismos de base única (SNP) nos genes das citocinas apresentam potencialidade para afetar a expressão gênica e/ou a atividade biológica da respectiva citocina, e existem evidências da associação de diferentes SNPs com a tuberculose em diversas populações diferentes. Os estudos envolvendo a influência de SNPs no gene da IL17A ainda são controversos, comportando-se de forma variada entre diferentes populações. Desta forma, a pesquisa da associação de SNPs no gene da IL17A com a evolução clínica da doença, poderá contribuir para um melhor entendimento da susceptibilidade e o desenvolvimento da TB. Para tanto, o objetivo do presente estudo foi avaliar a influência de SNPs no gene IL17A e a sua associação clínico-laboratorial em pacientes com tuberculose. Para tanto, foram estudados 35 pacientes com tuberculose e 26 controles. A avaliação dos SNPs no gene IL17A, rs7747909 e rs2275913, foi realizada através da técnica de discriminação alélica por PCR em tempo real. Os dados clínicos, laboratoriais e radiológicos foram obtidos através da coleta de prontuário. As análises foram realizadas pelo teste de Fisher, considerando valores significativos p<0,05. Não houve associação dos SNPs no gene IL17A avaliados, seja em relação à susceptibilidade ou quanto à associção clínica, laboratorial e radiológica. Por conseguinte, é fundamental o avanço em pesquisas para analisar a influência de outros SNPs no gene da IL17A e a relação com outras variáveis ligadas à resposta imune ao M. tuberculosis.
Niacinamide for the treatment of melasma: an integrative review of randomized clinical trials
Authors: Pedroso Adriana Giomo , Furtado Gisele Rosada Dônola , Barbosa Kledson Lopes 
Published: August 2022

Introduction: Melasma is a very common and difficult to treat hypermelanosis because it usually responds poorly to therapies, negatively affecting the quality of life of patients. Objective: to know and analyze the scientific evidence related to the treatment of patients with facial melasma treated with niacinamide. Method: a literature review was performed based on a data search in BIREME, PubMed, SciELO and ScienceDirect. Articles indexed in these electronic journals were included in the time frame from 2011 to 2019. Results: Evidence analyzes revealed a major impact on the appearance of facial melasma after niacinamide treatment. Well, the studies (100%) concluded improvement of the spots with the treatment time, improving the appearance of the skin. Conclusion: Evidence shows that niacinamide has a lightening property in adult women with improvement of melanic hyperpigmentation caused by melasma. However, there is very little evidence published in the last decade using pure niacinamide for increased pigmentation in melasma.
PENGUATAN PERAN WARGA MASYARAKAT DALAM MITIGASI DAN ADAPTASI MENGHADAPI WABAH COVID-19 DI KABUPATEN BUTON TENGAH
Authors: Zubaydah Wa Ode Sitti , Sida Nurramadhani A. 
Published: August 2022

In early 2020, Coronavirus Disease 2019 (COVID-19) was declared as a global pandemic by the World Health Organization (WHO). The number of positive cases of this virus continues to grow every day. Positive cases in Buton Tengah by 3 months increased up to 41 cases. Therefore the socialization of the mitigation and adaptation program of the people of Central of Buton during the COVID-19 outbreak needs to be done. The purpose is achievement of the ability to live a healthy life in the form of preventive measures to faced covid-19 outbreak. Mitigation programs carried out are the Healthy Living Community Movement (GERMAS), clean and healthy living behavior (PHBS), Community Movement using masks (GEMAS), TOGA and VCO, as well as the use of handsanitizers and disinfectants. The method was discourse directly to the public. The results obtained is increased public understanding of how to prevent COVID-19 infection in the mitigation program delivered. Conclusion is the mitigation socialization of COVID-19 received a very good response from the community, the residents felt very helped and there was an increase in community understanding and skills.
PENGOLAHAN DAN STRATEGI PEMASARAN PRODUK OLAHAN BURUNG PUYUH SEBAGAI ALTERNATIF PENINGKATAN INCOME SELAMA MASA PANDEMI COVID-19 DI KOTA KENDARI
Authors: Badaruddin Rusli , Sani La Ode Arsad , Sandiah Natsir , Syamsuddin Syamsuddin , Aka Rahim , Hadini Hairil A. , Auza Fuji Astuty , Indi Amiluddin 
Published: August 2022

Kendari City as the provincial capital has the highest incidence of positive covid-19 cases compared to other districts / cities in Southeast Sulawesi, Until April 23, 2020 there were 17 positive patients with Covid-19 who were undergoing treatment. This has implications for decreasing consumption and people's income because they cannot carry out normal activities. The steps taken by the central and local governments to combat the Covid-19 pandemic are by carrying out social distancing or social restrictions by limiting distances between individuals and avoiding crowds. Another government policy is the implementation of work from home (WFH) or activities from home for some employees and school children. This condition adversely affects the economy of Kendari city. One of the solutions offered is raising quail by utilizing the house yard. Quail maintenance is quite easy, does not require a large area and the maintenance system can be completed in a minimalist manner. Quail products consist of eggs and meat. Quail meat is processed into rica-rica quail meat and eggs are processed into quail egg nest tofu. KKN-THEMATIC aims to provide insights and knowledge about processing and marketing of processed quail products to the public. The method used is a persuasive participatory method with direct extension activities and practices. The results that have been achieved in this KKN-TEMATIK activity are an increase in the knowledge and understanding of breeders and the community in developing their business sustainability by making processed quail products, aswell as marketing management of processed quail products.
Rapid detection of Phytophthora cinnamomi based on a new target gene Pcinn13739
Authors: Chen Zhenpeng , Jiao Binbin , Zhou Jing , He Haibin , Dai Tingting 
Published: August 2022

Phytophthora cinnamomi causes crown and root wilting in more than 5,000 plant species and represents a significant threat to the health of natural ecosystems and horticultural crops. The early and accurate detection of P. cinnamomi is a fundamental step in disease prevention and appropriate management. In this study, based on public genomic sequence data and bioinformatic analysis of several Phytophthora, Phytopythium, and Pythium species, we have identified a new target gene, Pcinn13739; this allowed us to establish a recombinase polymerase amplification–lateral flow dipstick (RPA-LFD) assay for the detection of P. cinnamomi. Pcinn13739-RPA-LFD assay was highly specific to P. cinnamomi. Test results for 12 isolates of P. cinnamomi were positive, but negative for 50 isolates of 25 kinds of Phytophthora species, 13 isolates of 10 kinds of Phytopythium and Pythium species, 32 isolates of 26 kinds of fungi species, and 11 isolates of two kinds of Bursaphelenchus species. By detecting as little as 10 pg.µl−1 of genomic DNA from P. cinnamomi in a 50-µl reaction, the RPA-LFD assay was 100 times more sensitive than conventional PCR assays. By using RPA-LFD assay, P. cinnamomi was also detected on artificially inoculated fruit from Malus pumila, the leaves of Rhododendron pulchrum, the roots of sterile Lupinus polyphyllus, and the artificially inoculated soil. Results in this study indicated that this sensitive, specific, and rapid RPA-LFD assay has potentially significant applications to diagnosing P. cinnamomi, especially under time- and resource-limited conditions.
Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells
Authors: Barbosa Juliana Magalhães Chaves , Pedra-Rezende Yasmin , Pereira Luíza Dantas , de Melo Tatiana Galvão , Barbosa Helene Santos , Lannes-Vieira Joseli , de Castro Solange Lisboa , Daliry Anissa , Salomão Kelly 
Published: August 2022

Chagas disease (CD), a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, is an important public health problem mainly in Latin America, leading to approximately 12,000 annual deaths. Current etiological treatment for CD is limited to two nitro compounds, benznidazole (Bz) and nifurtimox (Nif), both presenting relevant limitations. Different approaches have been employed to establish more effective and safer schemes to treat T. cruzi infection, mostly based on drug repurposing and combination therapies. Amiodarone (AMD), an antiarrhythmic medicament of choice for patients with the chronic cardiac form of CD, is also recognized as a trypanocidal agent. Therefore, our aim is to investigate the combined treatment Bz + AMD on trypomastigote viability, control of T. cruzi intracellular form proliferation, and recovery of the infection-induced cytoskeleton alterations in cardiac cells. The combination of Bz + AMD did not improve the direct trypanocidal effect of AMD on the infective blood trypomastigote and replicative intracellular forms of the parasite. Otherwise, the treatment of T. cruzi-infected cardiac cells with Bz plus AMD attenuated the infection-triggered cytoskeleton damage of host cells and the cytotoxic effects of AMD. Thus, the combined treatment Bz + AMD may favor parasite control and hamper tissue damage.
Prevalence and associated factors of metabolic body size phenotype in children and adolescents: A national cross-sectional analysis in China
Authors: Liu Jieyu , Ma Tao , Chen Manman , Ma Ying , Li Yanhui , Gao Di , Ma Qi , Wang Xinxin , Chen Li , Zhang Yi , Dong Yanhui , Song Yi , Ma Jun 
Published: August 2022

BackgroundMetabolically healthy obesity (MHO) is a group of subjects with overweight/obesity who present a metabolically healthy profile; however, associated factors are complex and are far from completely understood. The aim of the current study was to estimate the prevalence of different metabolic body size phenotypes and investigate the associated factors in Chinese children and adolescents.MethodsA cross-sectional survey was conducted of 12,346 children and adolescents aged 7–18 years from seven provinces in China in 2013. Anthropometric, blood pressure, and biochemical measurements were obtained. A multi-component questionnaire covering demographic, neonatal, and lifestyle characteristics was administered. The classification of metabolic body size phenotype based on three definitions was compared. With metabolically healthy with normal weight (MHNW) as a reference group, logistic regression analyses were used to estimate the potential effects of associated risk factors, with adjustment for age, sex, single-child status, and residence area.ResultsThe prevalence of MHNW, MHO, metabolically unhealthy with normal weight (MUNW), and metabolically unhealthy overweight/obesity (MUO) phenotype was 68.6%, 2.0%, 26.4%, and 3.0%, respectively. There were 39.3% MHO and 60.7% MUO among obese participants and 72.2% MHNW and 27.8% MUNW among those with normal weight. Compared to cardiometabolic risk factor (CMRF) criteria and metabolic syndrome (MetS) component definition, the application of the 2018 consensus-based definition may identify more children with abnormal cardiovascular risks, independent of weight status. Compared to younger children, older-aged adolescents were positively associated with higher risks of MUNW (odds ratio (OR) = 1.38, 95% CI = 1.27–1.50) and MUO (OR = 1.29, 95% CI = 1.04–1.60), while factors positively associated with MHO were younger age, single-child status, urban residence, high birth weight, prolonged breastfeeding duration, parental overweight/obesity status, long screen time, and less physical activity.ConclusionThere were still a high proportion of children and adolescents at high cardiometabolic risk in China. Our findings reinforce the need for cardiometabolic risk prevention in children and adolescents irrespective of their weight statuses, such as parental educational programs and healthy lifestyle interventions.
A semiquantitative study of the optimal whole-body imaging time after 131I therapy for differentiated thyroid cancer
Authors: Liu Shuang , Zuo Rui , Yang Tianyu , Pang Hua , Wang Zhengjie 
Published: August 2022

ObjectiveWe compared the efficacy of post-therapy whole-body scintigraphy (Tx-WBS) in terms of detecting lesions in patients with differentiated thyroid cancer (DTC) on days 3, 7, and 10 after 131I treatment, and we determined the optimal imaging time.MethodsClinical data from 161 DTC patients treated with 131I were collected. All patients underwent day 3 imaging, but only 98 patients underwent day 3 and day 7 imaging, and 63 patients underwent day 3 and day 10 imaging at the same time. And the thyroid bed uptake was visually graded. The radioactivity ratios of the thyroid bed, neck lymph nodes, lungs, and liver (to the background) were calculated to allow a semiquantitative analysis.ResultsVisual analysis showed that delayed imaging revealed more lymph node and lung radioactivity, early imaging showed more residual thyroid tissue, and significant differences in uptake were apparent at days 3, 7, and 10 (P &lt; 0.001). Semiquantitative analysis revealed significant differences in the target-to-background ratios of the residual thyroid bed, lungs, and liver at days 3, 7, and 10. On these days, the imaging sensitivities in terms of detecting metastatic lymph nodes were 29.58%, 39.02%, and 19.35%, and the specificities were 75.56%, 75.86%, and 75% (P = 0.465, 0.154, and 0.763, respectively). In terms of lung metastasis detection, the sensitivities were 29.58%, 38.46%, and 13.33% respectively, and the specificities were 98.33%, 100%, and 95.83% (P &lt; 0.001, &lt; 0.001, and P=0.238).ConclusionMore residual thyroid tissue can be detected by imaging on day 3; imaging on day 7 more effectively detects lung metastases than does imaging on day 3 or 10.