bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of TonB-dependent receptors with susceptibility to cefiderocol in clinical isolates of Pseudomonas aeruginosa
Authors: Gupta Aanchal , Landman David , Quale John 
Published: January 2022

Abstract

Objectives
Cefiderocol maintains activity against most MDR Gram-negative pathogens including Pseudomonas aeruginosa. In laboratory-derived isolates, down-regulation of TonB-dependent siderophore receptors have been implicated in resistance to cefiderocol.

Methods
In this report, the expression of seven TonB-dependent siderophore receptors was examined in 10 clinical isolates with cefiderocol MICs ranging from ≤0.03–8 mg/L. In addition, genetic sequences of the siderophore receptors were analysed to identify potentially disruptive mutations.

Results
There was no clear association between expression of the receptors with cefiderocol susceptibility, including the receptors piuA/piuD and pirA previously implicated in cefiderocol uptake. In addition, there were no disabling mutations identified in the receptors. Acquired β-lactamase activity also could not explain the range in cefiderocol susceptibility.

Conclusions
The aetiology of reduced susceptibility to cefiderocol in clinical isolates of P. aeruginosa remains an enigma and worthy of further investigation.
The feasibility and generalizability of assessing the appropriateness of antimicrobial prescribing in hospitals: a review of the Australian National Antimicrobial Prescribing Survey
Authors: James Rodney , Nakamachi Yoshiko , Morris Andrew , So Miranda , Ponnampalavanar Sasheela Sri La Sri , Chuki Pem , Loong Ly Sia , Lai Pauline Siew Mei , Chen Caroline , Ingram Robyn , Rajkhowa Arjun , Buising Kirsty , Thursky Karin 
Published: January 2022

AbstractThe National Antimicrobial Prescribing Survey (NAPS) is a web-based qualitative auditing platform that provides a standardized and validated tool to assist hospitals in assessing the appropriateness of antimicrobial prescribing practices. Since its release in 2013, the NAPS has been adopted by all hospital types within Australia, including public and private facilities, and supports them in meeting the national standards for accreditation. Hospitals can generate real-time reports to assist with local antimicrobial stewardship (AMS) activities and interventions. De-identified aggregate data from the NAPS are also submitted to the Antimicrobial Use and Resistance in Australia surveillance system, for national reporting purposes, and to strengthen national AMS strategies. With the successful implementation of the programme within Australia, the NAPS has now been adopted by countries with both well-resourced and resource-limited healthcare systems. We provide here a narrative review describing the experience of users utilizing the NAPS programme in Canada, Malaysia and Bhutan. We highlight the key barriers and facilitators to implementation and demonstrate that the NAPS methodology is feasible, generalizable and translatable to various settings and able to assist in initiatives to optimize the use of antimicrobials.
Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS
Authors: Mahowald Grace , Khaliq Tahira , Basu Sankha , Griggs David , Siegel Molly , Leffert Lisa , Bernstein Sarah , Flood James G , Uljon Sacha 
Published: January 2022

Abstract

Background
Liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) is the gold standard for the measurement of fentanyl and norfentanyl (NF) in urine and is favored over immunoassays due to its superior specificity. NF is the principal metabolite of fentanyl found in the urine and is typically present in higher abundance than fentanyl. Thus, the sensitivity and specificity of LC–MS/MS relies largely on the ability to identify and quantitate NF.

Methods
We analyzed urine specimens from women who had received bupivacaine and fentanyl for epidural analgesia during labor. We analyzed the contents of the epidural bag itself and purified bupivacaine metabolite N-desbutyl bupivacaine [or N-(2,6-dimethylphenyl)piperidine-2-carboxamide (NDB)] by LC–MS/MS.

Results
NDB interferes with the LC–MS/MS assay for NF. NDB passes through the Q1 mass selection filter because it is isobaric with the NF precursor ion (233 m/z). Further, it shares product ions with NF (84 m/z and 150 m/z), used as quantifier and qualifier ions, respectively, in our urine NF detection method. Baseline resolution of NDB and NF using these quantifier and qualifier ions could not be achieved. A unique product ion of NF (177 m/z) was useful for distinguishing NDB from NF.

Conclusion
Bupivacaine is a commonly used drug. Recognition of this interference by laboratories is critical for preventing the misidentification of NF, which can have profound effects on patient care.
Effect of health information technology (HIT)-based discharge transition interventions on patient readmissions and emergency room visits: a systematic review
Authors: Abraham Joanna , Meng Alicia , Tripathy Sanjna , Kitsiou Spyros , Kannampallil Thomas 
Published: January 2022

Abstract

Objective
To systematically synthesize and appraise the evidence on the effectiveness of health information technology (HIT)-based discharge care transition interventions (CTIs) on readmissions and emergency room visits.

Materials and Methods
We conducted a systematic search on multiple databases (MEDLINE, CINAHL, EMBASE, and CENTRAL) on June 29, 2020, targeting readmissions and emergency room visits. Prospective studies evaluating HIT-based CTIs published as original research articles in English language peer-reviewed journals were eligible for inclusion. Outcomes were pooled for narrative analysis.

Results
Eleven studies were included for review. Most studies (n = 6) were non-RCTs. Several studies (n = 9) assessed bridging interventions comprised of at least 1 pre- and 1 post-discharge component. The narrative analysis found improvements in patient experience and perceptions of discharge care.

Discussion
Given the statistical and clinical heterogeneity among studies, we could not ascertain the cumulative effect of CTIs on clinical outcomes. Nevertheless, we found gaps in current research and its implications for future work, including the need for a HIT-based care transition model for guiding theory-driven design and evaluation of HIT-based discharge CTIs.

Conclusions
We appraised and aggregated empirical evidence on the cumulative effectiveness of HIT-based interventions to support discharge transitions from hospital to home, and we highlighted the implications for evidence-based practice and informatics research.
Into the matrix: current methods for mitochondrial translation studies
Authors: Apostolopoulos Antonios , Iwasaki Shintaro 
Published: January 2022

Abstract
In addition to the cytoplasmic translation system, eukaryotic cells house additional protein synthesis machinery in mitochondria. The importance of this in organello translation is exemplified by clinical pathologies associated with mutations in mitochondrial translation factors. Although a detailed understanding of mitochondrial translation has long been awaited, quantitative, comprehensive and spatiotemporal measurements have posed analytic challenges. The recent development of novel approaches for studying mitochondrial protein synthesis has overcome these issues and expands our understanding of the unique translation system. Here, we review the current technologies for the investigation of mitochondrial translation and the insights provided by their application.
‘Beautiful, plain objects like [SKF] ball bearings’: The Enigma of Aestheticizing Anonymity in ‘Machine Art’ and Modernist Logotypes
Authors: Shales Ezra 
Published: January 2022

Abstract
The SKF ball bearing on display in the 1934 ‘Machine Art’ exhibition in the Museum of Modern Art is an icon referenced throughout visual culture studies but this article recognizes its materiality, identifying the corporate logotype and other branded markings that complicate its identity as anonymous or, in the words of museum curator Philip Johnson, as ‘plain’. SKF, Svenska Kullagerfabriken (The Swedish ball bearing factory), had a fully developed global advertising campaign that made it a more established brand name than MoMA, and pioneered the contemporary mode of speaking and thinking in logotypes—by 1934, Johnson’s claim notwithstanding, no one could ‘see’ an SKF ball bearing without seeing the company’s logo. Scholarly commentary has adhered to MoMA’s description as if the bearing were anonymous and not visibly branded. This essay describes the history of the SKF logotype and situates it as both pioneering and part of a complex corporate culture and aspect of brand standardization that intersected with globalization in unexpected ways. To delve into the commercial context and production of ball bearings is to unravel the contradictions inherent in identifying design as national or global, and the modernist idealization of anonymous industrial form as an aesthetic ideal.
Nitric Oxide Fumigation for Control of Ham Mite, Tyrophagus putrescentiae (Sarcoptiformes: Acaridae)
Authors: Yang Xiangbing , Liu Yong-Biao , Singh Rippy , Phillips Thomas W 
Published: January 2022

Abstract
The ham mite, Tyrophagus putrescentiae (Schrank) (Sarcoptiformes: Acaridae), is a common pest infesting several stored products, particularly the aged hams. In this study, we reported the efficacy of nitric oxide (NO) fumigation, a recently discovered fumigation treatment under the ultra-low oxygen environment, at various concentrations and time under the laboratory conditions at 25°C against different mite stages on both dietary media and ham meat. Our results showed that NO fumigation was effective against all mite stages and 100% control was achieved. Generally, the egg was the most tolerant stage and required 48-, 24-, 16-, and 8-h treatments to achieve 100% mortality at 0.5, 1, 1.5, and 2% NO concentration on dietary media, respectively. Tyrophagus putrescentiae mobile immatures and adult stages were less tolerant, and 100% mortality was achieved after 16-, 8-, 8-, and 4-h treatment at 0.5, 1, 1.5, and 2% NO, respectively. The median lethal concentration (LC50) of NO on egg was 0.86, 0.68, and 0.32% for 8-, 16-, and 24-h treatments. In addition, a confirmatory test was conducted on ham meat at 0.5 and 1.0% of NO and similar efficacy was found. Complete control of egg was achieved after 48- and 24-h treatment at 0.5 and 1.0% of NO, respectively, and larvae and adult mites were 100% controlled after 16 and 8 h at 0.5 and 1.0% of NO, respectively. Our results demonstrated that NO fumigation was effective against T. putrescentiae and can be a potential alternative treatment to methyl bromide for cured-ham pest control.
Court Decisions in the Republic of Korea on Japan's Accountability for Sexual Slavery of the Comfort Women
Authors: Nam Seunghyun 
Published: January 2022

Abstract
On January and April of 2021, two contradictory decisions on the comfort women issue were ruled by two courts in the Republic of Korea (ROK), stirring much controversy on the various legal issues concerning the comfort women. In the January decision, the court held Japan accountable for the acts committed against the comfort women and denied Japan’s immunity in the courts of the ROK because these atrocities constitute crimes against humanity when Japan illegally occupied Korea. On the other hand, the April decision, which was a case for another group of comfort women victims, dismissed the suit by ruling that Japan was rather immune on this issue in ROK courts because state immunity is considered to be part of customary international law. The court specifically referred to the Jurisdictional Immunities case before the International Court of Justice which found that violations of jus cogens as a substantive norm could not trump over procedural matters such as state immunity. As the April case has been appealed by the victims, this article aims to examine the historical background of the issue of comfort women and the main legal issues of these domestic decisions. The first issue concerns whether Japan is immune in ROK courts for even alleged violations of jus cogens, and the second issue is whether the individual claims of the comfort women are still valid today or whether they have been, as a matter of law, extinguished or waived through the 1965 Claims Agreement and the 2015 Agreement signed by both the ROK and Japan.
Robust schedules for tardiness optimization in job shop with interval uncertainty
Authors: Díaz Hernán , Palacios Juan José , Díaz Irene , Vela Camino R , González-Rodríguez Inés 
Published: January 2022

AbstractThis paper addresses a variant of the job shop scheduling problem with total tardiness minimization where task durations and due dates are uncertain. This uncertainty is modelled with intervals. Different ranking methods for intervals are considered and embedded into a genetic algorithm. A new robustness measure is proposed to compare the different ranking methods and assess their capacity to predict ‘expected delays’ of jobs. Experimental results show that dealing with uncertainty during the optimization process yields more robust solutions. A sensitivity analysis also shows that the robustness of the solutions given by the solving method increases when the uncertainty grows.
A new copyright law in the UAE
Authors: Al-Sharieh Saleh 
Published: January 2022

ABSTRACT
The Federal Decree-Law No. 38 of 2021 on Copyright and Related Rights, published in the Official Gazette, Issue No. 712, on 26 September 2021
On 2 January 2022, the Federal Decree-Law No. 38 of 2021 on Copyright and Related Rights (‘Federal Decree-Law No. 38’), repealing the Federal Law No. 7 of 2002 on Copyrights and Related Rights (‘repealed law’), came into force in the United Arab Emirates. It seeks to facilitate the transition into the knowledge economy and implement the Marrakesh Treaty to Facilitate Access to Published Works for Persons Who Are Blind, Visually Impaired, or Otherwise Print Disabled (‘Marrakesh Treaty’).
Host Plant-Based Artificial Diets Enhance Development, Survival and Fecundity of the Edible Long-Horned Grasshopper Ruspolia differens (Orthoptera: Tettigoniidae)
Authors: Leonard Alfonce , Egonyu James P , Tanga Chrysantus M , Kyamanywa Samuel , Ekesi Sunday , Khamis Fathiya M , Subramanian Sevgan 
Published: January 2022

Abstract
Wild swarms of the long-horned grasshoppers Ruspolia differens (Serville) which are widely harvested for consumption and sale in Africa are seasonal and unsustainable, hence the need for innovative ways of artificially producing the insects. We investigated the development, survival, and reproduction of R. differens in the laboratory on diets mixed with host plants [Digitaria gayana Kunth, Cynodon dactylon (L.) and Megathyrsus maximus Jacq (Poales: Poaceae); Ageratum conyzoides L. (Asterales: Asteraceae)] identified from guts of their wild conspecifics with a view to developing a suitable diet for artificial mass rearing of the edible insect. A standard diet comprising ground black soldier fly, Hermetia illucens L. (Diptera: Startiomyidae) larvae, soybean flour, maize flour, vitamin premix, and ground bones was tested for rearing R. differens as a control against the same ingredients incorporated with individual powders of the different host plants. Whereas R. differens developed more slowly in the diet mixed with D. gayana than in the control diet; its development was faster in the diet mixed with C. dactylon. Mortalities of R. differens in host plant-based diets were 42.5–52.5%, far lower than in the control diet with 71% mortality. The insects raised on the diet mixed with M. maximus laid approximately twice more eggs compared to R. differens fecundities from the rest of the diets. However, inclusion of host plants in the diets had no detectable influence on R. differens adult weight and longevity. These findings support inclusion of specific host plants in artificial diets used for mass rearing of R. differens to enhance its survival, development, and fecundity.
Identification of a Subset of Stage I Colorectal Cancer Patients With High Recurrence Risk
Authors: Lee Lik Hang , Davis Lindy , Ylagan Lourdes , Omilian Angela R , Attwood Kristopher , Firat Canan , Shia Jinru , Paty Philip B , Cance William G 
Published: January 2022

Abstract

Background
A challenge in early-stage colorectal cancer (CRC) is identifying biomarkers that predict an increased risk for recurrence. A potential clinically adaptable biomarker is focal adhesion kinase (FAK), a tyrosine kinase that promotes invasion and metastasis.

Methods
An initial, single-institution, 298-patient cohort with all stages of CRC and long-term follow-up was assessed for FAK with tissue microarrays using immunohistochemistry. FAK expression was scored and dichotomized into high and low. Subsequently, a validation cohort of 517 early-stage CRCs from a separate institution was evaluated. All statistical tests were 2-sided.

Results
FAK overexpression did not correlate with any known histologic feature and was an early event in CRC, increasing from normal colon to stage I, and stage I to II, but not different at higher stages. High FAK was associated with decreased 10-year recurrence-free survival (RFS) among stage I patients (70.2% for high FAK vs 94.1% for low, P = .02), but not among higher stages in the initial cohort. The same finding was seen in the validation cohort (73.1% for high FAK vs 93.1% for low, P = .004). Multivariable survival analysis for stage I patients showed only two statistically significant factors predicting RFS: FAK (hazard ratio = 5.27, 95% confidence interval = 1.81 to 15.33, P = .002) and perineural invasion (hazard ratio = 7.38, 95% confidence interval = 1.01 to 53.96, P = .049). FAK was the only statistically significant factor in multivariable analysis across RFS, overall, and disease-specific survivals.

Conclusions
High FAK expression identified a subset of stage I CRC patients with high incidence of recurrence and reduced survival, suggesting that FAK has important prognostic value. These patients would immediately benefit from more rigorous surveillance protocols for recurrent disease.
Gynaecomastia-like change of a female breast with tri-layer ductal epithelium as described in the male breast
Authors: Fink Teagan , Deb Siddhartha , Chakrabarti Anannya 
Published: January 2022

Abstract
A 31-year-old female presented with asymmetrical fullness in the right breast and was found to have a large span of fibrocystic change and nodular glandular tissue on magnetic resonance imaging. Breast malignancy could not be excluded, and thus excisional biopsy was performed. Histopathology revealed a rare finding of gynaecomastia-like histopathological changes of a female breast. Gynaecomastia is traditionally a clinical condition affecting the male breast and characterized by ductal hyperplasia, periductal fibrosis and oedema of the tissue. We describe the first finding of gynaecomastia-like change with a tri-layer ductal epithelium in a female breast, as previously described in the male breast.
Imprints of the cosmic void evolution on the baryon processes inside galaxy haloes
Authors: Rodríguez Medrano Agustín M , Paz Dante J , Stasyszyn Federico A , Ruiz Andrés N 
Published: January 2022

ABSTRACT
Cosmic voids provide a unique environment to study galaxy formation and evolution. In this paper, we analyse a set of hydrodynamic zoom-in simulations of voids, to analyse in detail their inner structures. These voids were identified in a cosmological simulation and classified according to their surrounding dynamics at very large scales: whether they are in expansion or contraction at their outskirts. We study how these environments and the dynamics of voids impact the baryonic processes inside haloes and their mechanisms of formation and evolution. We find an underabundance of processed gas within the voids that can be associated with the lack of massive haloes. By studying the dynamical phase-space diagram of haloes and the halo-particle correlation function, we find that haloes inside of contracting voids are slightly affected by the presence of bigger structures, in comparison to haloes in the inner regions of expanding voids. This fact is consistent when you see dark matter or gas particles. We show that the halo assembly depends on the void dynamical state: haloes in expanding voids assemble slowly than those in contracting voids and in the general universe. This difference in the assembly impacts the baryonic evolution of haloes. Overall the redshift range analysed that haloes in voids have less baryon content than haloes in the general universe and particularly at z = 0 less stellar content. Our results suggest that the large-scale void environment modulate the baryonic process occurring inside haloes according to the void dynamical state.
Dark Energy Survey Year 3 results: marginalization over redshift distribution uncertainties using ranking of discrete realizations
Authors: Cordero Juan P , Harrison Ian , Rollins Richard P , Bernstein G M , Bridle S L , Alarcon A , Alves O , Amon A , Andrade-Oliveira F , Camacho H , Campos A , Choi A , DeRose J , Dodelson S , Eckert K , Eifler T F , Everett S , Fang X , Friedrich O , Gruen D , Gruendl R A , Hartley W G , Huff E M , Krause E , Kuropatkin N , MacCrann N , McCullough J , Myles J , Pandey S , Raveri M , Rosenfeld R , Rykoff E S , Sánchez C , Sánchez J , Sevilla-Noarbe I , Sheldon E , Troxel M , Wechsler R , Yanny B , Yin B , Zhang Y , Aguena M , Allam S , Bertin E , Brooks D , Burke D L , Carnero Rosell A , Carrasco Kind M , Carretero J , Castander F J , Cawthon R , Costanzi M , da Costa L , da Silva Pereira M E , De Vicente J , Diehl H T , Dietrich J , Doel P , Elvin-Poole J , Ferrero I , Flaugher B , Fosalba P , Frieman J , Garcia-Bellido J , Gerdes D , Gschwend J , Gutierrez G , Hinton S , Hollowood D L , Honscheid K , Hoyle B , James D , Kuehn K , Lahav O , Maia M A G , March M , Menanteau F , Miquel R , Morgan R , Muir J , Palmese A , Paz-Chinchon F , Pieres A , Plazas Malagón A , Sánchez E , Scarpine V , Serrano S , Smith M , Soares-Santos M , Suchyta E , Swanson M , Tarle G , Thomas D , To C , Varga T N ,   (DES Collaboration)
Published: January 2022

ABSTRACT
Cosmological information from weak lensing surveys is maximized by sorting source galaxies into tomographic redshift subsamples. Any uncertainties on these redshift distributions must be correctly propagated into the cosmological results. We present hyperrank, a new method for marginalizing over redshift distribution uncertainties, using discrete samples from the space of all possible redshift distributions, improving over simple parametrized models. In hyperrank, the set of proposed redshift distributions is ranked according to a small (between one and four) number of summary values, which are then sampled, along with other nuisance parameters and cosmological parameters in the Monte Carlo chain used for inference. This approach can be regarded as a general method for marginalizing over discrete realizations of data vector variation with nuisance parameters, which can consequently be sampled separately from the main parameters of interest, allowing for increased computational efficiency. We focus on the case of weak lensing cosmic shear analyses and demonstrate our method using simulations made for the Dark Energy Survey (DES). We show that the method can correctly and efficiently marginalize over a wide range of models for the redshift distribution uncertainty. Finally, we compare hyperrank to the common mean-shifting method of marginalizing over redshift uncertainty, validating that this simpler model is sufficient for use in the DES Year 3 cosmology results presented in companion papers.