bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Gemcitabine Plus Nab-Paclitaxel-Based Chemotherapy Regimen as First-Line Treatment in Metastatic Pancreatic Carcinoma
Authors: Domadia Kshitij , Goel Varun , Koyyala Venkata Pradeep Babu , Patnaik Nivedita , Chaudhari Krushna , Raina Shubhra , Doval D. C. , Talwar Vineet 
Published: January 2022

Background The purpose of this study was to study the effectiveness of gemcitabine and nab-paclitaxel combination as first-line chemotherapy regimen for the treatment of metastatic pancreatic cancer. There is scarcity of data regarding efficacy and toxicity profile of this combination in Indian population.
Aims and Objectives The primary aim of this study was to assess efficacy of this regimen, for which evaluation done in terms of the objective response rate, progression-free survival (PFS), and overall survival. Safety data were also evaluated.
Materials and Methods In this prospective study, gemcitabine plus nab-paclitaxel combination chemotherapy was given as first line in metastatic pancreatic carcinoma patients till progression or appearance of grade 3/4 toxicities with treatment.
Results The study was performed in 30 patients comprising 18 (60%) males and 12 (40%) females. The median age was 60 years. Median number of cycles administered were six cycles per patient. Seventeen patients (56.67%) had a partial response and 0% had complete response. A total of seven (23.3%) patients progressed on chemotherapy and six (20%) had stable disease (SD). The disease control rate (responses and SD) was 76.7%. The median PFS was 5.75 months. There was no statistically significant difference in terms of response rates and baseline CA 19-9 levels. Most common toxicities were hematological toxicities with rates of grade 3/4 anemia and neutropenia of 20%. Among nonhematological toxicities, nausea (46.67%) and fatigue (30%) were the commonest.
Conclusion Combination of gemcitabine and nab-paclitaxel is active and well tolerated in advanced pancreatic carcinoma. To the best of our knowledge, this is the first such study conducted in India.
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer with Peritoneal Metastasis—Indian Experience
Authors: S.P Somashekhar , Karivedu Jyothsana , C. Rohit Kumar , Y. Ramya , Kapoor Priya , Rauthan Amit , K.R Ashwin 
Published: January 2022

Introduction Peritoneal metastasis secondary to gastric cancer is associated with poor prognosis. Recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may be an efficacious treatment option for an otherwise palliative condition.
Methods A retrospective single institutional study of patents diagnosed with gastric carcinoma and peritoneal metastasis and treated with CRS and HIPEC from February 2015 to December 2019.
Results Sixteen patients with gastric cancer and peritoneal carcinomatosis were treated with CRS and HIPEC. Three patients underwent upfront surgery, and five patients underwent interval surgery. The mean peritoneal cancer index (PCI) was 3.5, and adequate complete cytoreduction (CC) score of 0/1 was achieved in all patients. All patients received HIPEC with mitomycin C. Major surgical complications were in 12.5% of patients. Grade I surgical site infection was present in one patient. Three patients had prolonged gastrointestinal (GI) recovery. The 30-day mortality was zero. Median follow-up time was 39 months. The median progression-free survival (PFS) was 12 months (95% conﬁdence interval [CI] 6.86–17.13). The median overall survival (OS) was 17 months (95% CI 6.36–27.64).
Conclusion Multidisciplinary treatment of perioperative chemotherapy with CRS and HIPEC is a promising treatment option, which may prolong survival in selected patients, and large randomized clinical trials are warranted for it to become standard of care.
Association Between Sensorineural Hearing Loss and Various Stages of Chronic Kidney Disease
Authors: Kotian Shashank , Naik Ashok S. , Revanasiddappa Manjunath , Goutham Maniyankode Krishnamohan 
Published: January 2022

Abstract
Objectives To compare the proportion of sensorineural hearing impairment (SHI) among patients of chronic kidney disease (CKD) stages 3&4 with CKD stage 5.
Materials and Methods This is a cross-sectional study of 30 patients with CKD stages 3 and 4 and 30 patients in stage 5. All patients had an audiological evaluation with pure tone audiometry.
Results Our study had 49 males (82%) and 11 females (18%), with the age ranging from 20 to 60 years (mean: 45.13 years). The mean SHI values in stage 3&4 were 28.44 dB and in CKD stage 5 was 31.22 dB. In the right ear, the mean hearing loss in stage 3, stage 4, and stage 5 was 28.17 dB, 28.67 dB, and 31.84 dB, respectively. In the left ear, the mean SHI values in stage 3, stage 4, and stage 5 were 27.05 dB, 31.89 dB, and 30.61 dB, respectively.The mean SHI in stage 3&4 for age group 20 to 30 years was 13.66 dB, for 31 to 40 years was 26.33 dB, for 41 to 50 years was 35.18 dB, for 51 to 60 years was 37.12 dB. The mean SHI in stage 5 for the age group of 20 to 30 years was 16.48 dB, for 31 to 40 years was 28.29 dB, for 41 to 50 years was 31.82 dB, for 51 to 60 years was 34.35 dB. There was a significant correlation between hearing loss and CKD with respect to age (p < 0.001). The duration of renal illness and associated comorbidities was not a significant contributor to hearing loss in our study (p > 0.05).
Conclusion As per our study, with progression in the stage of chronic kidney disease, the hearing loss also increased indicating a possible link between the two. We also noted that the hearing loss increased with the increasing age.
Clinically Undetected Hodgkin Lymphoma Diagnosed Initially on Bone Marrow Biopsy: A Large Retrospective Observational Study from a Tertiary Care Center
Authors: Vangala Navatha , Paul Tara Roshni , Uppin Shantveer G. , Uppin Megha S. , Sadashivudu G. , Raju Y. Satyanarayana , Rao M. Nageswara 
Published: January 2022

Abstract
Introduction Hodgkin lymphoma (HL) involving the bone marrow (BM) is relatively rare with an incidence ranging from 4% to 18%. The incidence of primary HL of marrow is 0.25%. To the best of our knowledge, the present study is the largest study on HL diagnosed initially on marrow biopsy.
Objective To establish diagnostic criteria based on clinicopathological and histological features in HL diagnosed first on the marrow.
Materials and Methods This was a retrospective study done from January 2012 to December 2020 that included 36 cases of HL diagnosed initially on BM. Based on the presence of large mononuclear or binucleate Reed–Sternberg (RS)-like cells in a polymorphous inflammatory background, HL was suspected and immunohistochemistry (IHC) with CD15 and CD30 was done. Correlation with subsequent lymph node biopsies was done, wherever possible.
Results Fever (94.4%) was the most common symptom, followed by loss of weight (66.7%). Twenty-one cases (58.4%) had uni/bicytopenia and 15 cases (41.6%) had pancytopenia. Only one case showed suspicious mononuclear RS cells on aspirates and the rest of the cases were diagnosed on trephine biopsy alone. Trephine imprints showed variable cellularity in 13 (36%) cases. Diffuse involvement was seen in 24 cases (66.7%), and focal nodular aggregates were seen in 12 cases (33.3%). Out of 36 cases, 26 cases (19 cases on marrow and 7 cases on lymph node) were confirmed as HL with IHC. Immunophenotype of the RS cells on the marrow was CD30+/CD15+ in (6/29) (20.7%) cases, CD30+/CD15− in (7/29) (24.1%) cases and CD30−/CD15+ in (6/29) (20.7%) cases. Seven cases (26.9%) were diagnosed on subsequent lymph node biopsy as mixed cellularity HL with IHC confirmation. Marrow fibrosis was seen in 16 cases (44.4%), and granulomas were seen in 8 cases (22.2%).
Conclusion In cases presenting with long-standing fever and cytopenias, HL must always be suspected, even if there are no palpable lymph nodes. Bone marrow biopsy is preferable over aspiration in such cases and IHC plays a major role in diagnosing the cases.
Ischemic Stroke in Young Adults Caused by Cervical Artery Dissection—A Retrospective Study
Authors: Jazbec Lucija , Menih Marija , Arh Rok 
Published: January 2022

Abstract
Background Ischemic stroke is one of the most common causes of death and disability. The most common independent cause is cervical artery dissection, which represents around 20% of all cases of ischemic stroke in young adults. Risk factors for dissection include male gender, migraine (particularly with aura), hyperhomocysteinemia, recent infection, recent history of minor cervical trauma, young age, current smoking status, increased leucocyte count, and shortened activated partial thromboplastin time, whereas hypercholesterolemia and being overweight appear protective.
Patients and Methods This retrospective study was based on data of all patients aged 18 to 49 who were hospitalized in the University Medical Centre Maribor for ischemic stroke between 2010 and 2019 inclusive. The results of the research were analyzed by IBM SPSS Statistics 28 software. For statistical significance, a cut-off value of p < 0.05 was used.
Results The study includes 196 patients with 198 events of ischemic stroke. Dissection of cervical arteries was presented in 16 (8.2%) cases. The presence of arterial hypertension proved to have a relation with the presence of a dissection; patients with dissection are less likely to suffer from arterial hypertension. Duration of hospitalization in the group with dissection lasted significantly longer than in the group without dissection.
Conclusions Dissection of cervical or intracranial artery is an important cause of ischemic stroke, especially in young adults. Therefore, it should be considered in young adults with presentation of stroke who lack traditional and modifiable risk factors.
Radiographic Landmarks for Ideal Port Placement in Wrist Arthroscopy
Authors: Thayer Jacob , Lee Greg , Mailey Brian 
Published: January 2022

Abstract
Background The placement of wrist arthroscopy portals is traditionally performed using distances from anatomic landmarks. We sought to evaluate the safety of traditional portal placement and determine if radiographic landmarks could provide an additional method of identifying tendon intervals.
Methods Six cadaveric specimens were used to evaluate the accuracy of portal placement based on anatomic and radiographic landmarks. Fluoroscopic images were used to document the location of previously described surface landmarks. Soft tissue was dissected away to identify the relationship between the transcutaneously placed portals and the extensor tendons. With soft tissue removed, tendon intervals were identified in relationship to anatomic carpal bone landmarks, and interval distances measured. Portals were then placed under radiographic imaging on the final three specimens and accuracy was examined by the removal of overlying soft tissue to confirm accurate interval placement
Results The 3,4 portal was safely placed using only surface anatomic landmarks, however the 4,5 and midcarpal ulnar (MCU) portal sites were not consistently placed in the intended tendon interval, especially in larger wrists. Radiographic interval targets for the 3,4 portal were identified at the ulnar aspect of the scaphoid and the 4,5 portal at the ulnar one-third of the lunate. The radiographic site for the MCR was located at the inferior radial one-third of the capitate and the MCU portal was located at the radial aspect of the hamate. The 6R portal radiographic landmark is at the radial aspect of the triquetrum and 6U at the ulnar aspect of the triquetrum.
Conclusion Portal placement in wrist arthroscopy based on anatomic landmarks alone can be unreliable in larger wrists. Radiographic imaging based on carpal bone landmarks provides an additional tool for consistent placement of portals in wrist arthroscopy and may limit unintended injury to extensor tendons.
Level of Evidence This is a Level VI study.
Clinical, Morphological, and Molecular Study of Diffuse WHO Grade II and III Astrocytomas: A Retrospective Analysis from a Single Tertiary Care Institute
Authors: Veduruvada Ramya Lakshmi , Uppin Megha S. , Konatam Meher Lakshmi , Alugolu Rajesh , Yeramneni Vamsi Krishna , Bhattacharjee Suchanda , Saradhi Mudumba Vijaya , Irukulla Monica Malik , Rao Madhumohan , Velugonda Nagaraj 
Published: January 2022

AbstractIntroduction Astrocytomas are the most common gliomas, classified on the basis of grade and IDH mutation status according to the World Health Organization (WHO) 2016 update. IDH mutations are seen in 70 to 80% of diffuse grade II and III astrocytomas and are associated with better outcome. They serve as predictive biomarker in IDH-targeted therapies such as small-molecule inhibitors or vaccines.Objective The aim of this study was to analyze the clinical, morphological, immunohistochemical, and molecular genetic characteristics of diffuse astrocytoma (DA: grades II and III). The IDH mutant and wild-type tumors are compared and contrasted with survival analysis on follow-up.Materials and Methods This was a retrospective study conducted on surgically resected tumor specimens. The hematoxylin and eosin-stained slides were examined for histologic features. Immunohistochemistry (IHC) was performed using IDH1R132H, ATRX, p53, and Ki67. All cases of negative immunohistochemical expression of IDH1R132H were subjected to IDH1 mutation analysis by Sanger sequencing. Overall survival was estimated by the Kaplan-Meier method using the log-rank (Mantel–Cox) test.Results The study included 51 cases of DA in the age of 17 to 66 years, mean ± standard deviation was 35.5 ± 9.7 years, and male:female ratio was 2:1.The IDH1R132H cytoplasmic immunopositivity was seen in 36 cases (70.5%), of which 63.6% were of grade II and 72.5% were of grade III. ATRX showed loss of expression in 50 cases (98%), and p53 showed diffuse strong immunohistochemical expression in all the cases of IDH mutant tumors. The difference in the age at presentation for IDH mutant (32.5 years) and wild type tumors (38 years) was statistically significant. Median survival was 55.3 months and 22.2 months in of IDH mutant and wild type cases, respectively.Conclusion IHC and sequencing for IDH mutations is helpful in making an integrated diagnosis and classifying definite molecular subgroups of astrocytic tumors. Mutations in IDH core-elate with survival. IDH mutant tumors showed longer survival duration and are good prognostic indicators.
Use of Biologic Agents for Lip and Cheek Reconstruction
Authors: Depani Monal , Ferry Andrew M. , Grush Andrew E. , Moreno Tanir A. , Jones Lloyd M. , Thornton James F. 
Published: January 2022

AbstractThe unique requirements of reconstructing cheek defects, often with its proximity to the mobile elements of the face including the lip and the eyelid, have been met very handily with the directed and thoughtful use of biologic wound healing agents. One of the key advantages of these agents is their ability to provide coverage for the mobile elements of the cheek and the lip in patients with multiple co-morbidities. These agents are successfully used where the standard cheek closure techniques including cervicofacial advancement flap are contraindicated due to its anesthetic requirement. Additionally, lip reconstruction involves examining the lip's three anatomic layers: mucosa, muscle, and skin. The defects must be planned for reconstruction based on the involvement of these layers. This paper serves to introduce the use of biologic wound healing agents depending on the involvement of these layers. The authors provide specific illustrations of these agents based on defect location, tissue involvement, and severity of the defect to help with procedural planning to reconstruct a very aesthetically involved part of the face.
Beyond “Doing as the Romans Do”: A review of research on countercultural business practices
Authors: Caprar Dan V. , Kim Sunghoon , Walker Benjamin W. , Caligiuri Paula 
Published: January 2022

AbstractThere has long been a dominant logic in the international business literature that multinational corporations should adapt business practices to “fit” host cultures. Business practices that are congruent with local cultural norms have been advocated as effective and desirable, while practices that are incongruent have been deemed problematic. We examine and challenge this persistent assumption by reviewing the literature showing evidence for both benefits and acceptance of countercultural practices (i.e., practices that are seemingly incongruent with local cultural norms or values), and disadvantages and rejection of local practices. Drawing on the literature reviewed, we offer four types of theoretical (ontological, epistemological, causal, and functional) explanations as to why and when countercultural business practices might be preferred. Finally, we provide a springboard for a future research agenda on countercultural practices, centered around understanding the circumstances under which businesses and local stakeholders might benefit from the use of countercultural practices based on such factors as strategic intent, local preferences, institutional drivers, and social responsibility.
Single-Point And Triple-Point Queries Visibility Constrained Minimum Link Paths In Simple Polygons
Authors: Reza Zarrabi Mohammad , Moghaddam Charkari Nasrollah 
Published: January 2022

AbstractWe study the query version of constrained minimum link paths between two points inside a simple polygon $P$ with $n$ vertices such that there is at least one point on the path, visible from a query point. The method is based on partitioning $P$ into a number of faces of equal link distance from a point. This partitioning is essentially a link-based shortest path map. Initially, we solve this problem for two given points $s$, $t,$ and a query point $q$. Then, the proposed solution is extended to a general case for three arbitrary query points: $s$, $t$ and $q$. In the former case, we propose an algorithm with $O(n)$preprocessing time. For the latter case, we develop an algorithm with $O(n^3)$ preprocessing time. The link distance of a $q$-$visible$ path between $s$, $t$ and the path are provided in time $O(\log n)$ and $O(m+\log n)$, respectively, for the above two cases, where $m$ is the number of links.
Regularizing the 3-D teleseismic wavefield for receiver function imaging using a radial basis function
Authors: Xie Chengliang , Fang Yuanyuan , Zhang Jinhai 
Published: January 2022

SUMMARY
Receiver function is important for imaging crustal and upper-mantle discontinuities. However, sparsely scattered stations could introduce imaging artefacts or misinterpretations for complex structures. We regularize a 3-D teleseismic wavefield to reduce these artefacts using radial basis function interpolation. First, we evaluated the feasibility of wavefield regularization with several typical models using synthetic data. The results demonstrate the high reliability of our method for recovering local 2-D and 3-D structures, even when seismic stations intentionally miss 95 per cent of a uniform fine grid. Then, we applied this method to sparsely deployed stations in Northeast China. The waveforms reconstructed from surrounding stations show good consistency with the observed waveforms; furthermore, the imaging results using the regularized data are highly comparable with the reference results obtained by using a dense 2-D seismic array of 60 stations (with a spacing of 10–17 km), even though our input data were mainly contributed by only 9 stations (with an average spacing of ∼80 km). Our results show better continuity of the 3-D topography of the subsurface compared with that obtained by the traditional method. Our regularization method could significantly improve the spatial resolution of receiver function imaging for both sparse and dense distributions of seismic stations, especially for imaging relatively complex structures with lateral variations.
Arbitrage Pricing with Heterogeneous Spatial Effects and Heteroscedastic Disturbances
Authors: Hu Jianhua , Ding Hao , Liu Xiaoqian 
Published: January 2022

Abstract
We develop a heterogeneous spatial arbit and regression coefficients, and heteroscedastic variances, and further establish identification of parameters and asymptotic normality of the conditional QML estimators under some mild conditions. We apply the proposed model to study a real data set of 11 eurozone stock index returns and extend the Fama–French five-factor model to regional stock indices, in which heterogeneous spatial effects and heteroscedastic disturbances are highly significant and they both play very important roles in explaining distinct endogenous effects and distinct risks of the 11 eurozone stock markets. Our empirical results reveal unique characteristics of each of 11 eurozone stock markets and their inner connections.
Extrapleural pneumonectomy for recurrent thymoma diagnosed after return of paraneoplastic Morvan syndrome
Authors: Banks Kian C , Hsu Diana S , Velotta Jeffrey B 
Published: January 2022

Abstract
A 50-year-old male with history of HIV, syphilis, paraneoplastic Morvan syndrome secondary to thymoma resected in 2013 presented recently with tachycardia, tremors, diarrhea, hyperhidrosis and bilateral lower extremity pain leading to the discovery of thymoma recurrence. He initially developed Morvan Syndrome after thymectomy in 2013 and gradually improved with negative anti-contactin-associated protein-like 2 antibody testing in 2017 and symptom resolution in 2018. Upon return of dysautonomia symptoms, subsequent imaging revealed widespread disease recurrence diffusely in the right lung parenchyma and pleura for which he underwent right extrapleural pneumonectomy. He was managed with low-dose prednisone perioperatively, but when his symptoms worsened, he was started on rituximab and methylprednisolone. Nearly 3 months from surgery, he died from urinary sepsis. This represents a unique case of recurrent paraneoplastic Morvan syndrome leading to the diagnosis of metastatic thymoma as well as the challenges of symptom control during the surgical management of the underlying disease.
Radial stellar populations, kinematics, and photometry of the cD galaxy NGC 6086 in Abell 2162
Authors: Pérez-Hernández E , Kemp S N , Ramirez-Siordia V H , Nigoche-Netro A 
Published: January 2022

ABSTRACT
We present a full study of deep optical long-slit spectroscopy and deep broad-band photometry of NGC 6086. We cover up to at least 3re in spectroscopy and 5re in photometry (re ≈ 22 arcsec in our V-band photometry). The envelope first appears in the photometric profile around 23 arcsec, and the velocity dispersion, age, metallicity, and Mg2 indices all show changes starting at about this radius suggesting that we are seeing two separate structures (ellipsoid and envelope) with different properties in the data. We do not find the kinematically decoupled core reported in Carter et al. The velocity dispersion profile rises from 300 km s−1 in the centre to 600 km s−1 at 40 arcsec, a similar tendency to that previously observed in NGC 6166. Populations indicate a trend from old metal-rich stars to younger metal-poorer ones as the radius increases. Line-index analysis indicates that the α-element proportion is high at all radii and that the Mg2 index declines relatively steeply with radius. The photometry shows the extended envelope with a Sérsic index of 0.6 and flat colour gradients. Previous measurements of the velocity dispersion of the galaxies in the cluster A2162 are in the range 300–420 km s−1 for only around 40 member galaxies, but there appears to be a radial discontinuity in the distribution of galaxies and a flattish distribution in radial velocity, implying that the kinematics of this cluster requires further investigation.