bluuebunny/crossref_metadata_2025_split huggingface dataset:
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Authors: Martin Sheree D. , Connor Timothy , Sanigorski Andrew , McEwen Kevin A. , Henstridge Darren C. , Nijagal Brunda , Souza David De , Tull Dedreia L. , Meikle Peter J. , Kowalski Greg M. , Bruce Clinton R. , Gregorevic Paul , Febbraio Mark A. , Collier Fiona M. , Walder Ken R. , McGee Sean L. 
Published: October 2022

ABSTRACTLipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5), which reduced the expression of metabolic genes and oxidative metabolism in skeletal muscle, resulting in increased non-oxidative glucose metabolism. This metabolic reprogramming was also associated with impaired apoptosis and ferroptosis responses, and preserved muscle cell viability in response to lipotoxicity. Mechanistically, increased HDAC4 and 5 decreased acetylation of p53 at K120, a modification required for transcriptional activation of apoptosis. Redox drivers of ferroptosis derived from oxidative metabolism were also reduced. The relevance of this pathway was demonstrated by overexpression of loss-of-function HDAC4 and HDAC5 mutants in skeletal muscle of obesedb/dbmice, which enhanced oxidative metabolic capacity, increased apoptosis and ferroptosis and reduced muscle mass. This study identifies HDAC4 and HDAC5 as repressors of skeletal muscle oxidative metabolism, which is linked to inhibition of cell death pathways and preservation of muscle integrity in response to lipotoxicity.
miR-495-3p Sensitizes BCR::ABL1 Expressing Leukemic cells to Tyrosine Kinase Inhibitors by Targeting Multidrug Resistance 1 Gene including in T315I Mutated cells
Authors: Rittavee Yutthana , Artus Jérôme , Desterke Christophe , Simanic Isidora , Eduardo Botelho de Souza Lucas , Riccaldi Sandra , Coignard Sabrina , Ijjeh Yousef , Hughes Patricia , Bennaceur-Griscelli Annelise , Turhan Ali G. , Foudi Adlen 
Published: October 2022

ABSTRACTChronic myeloid leukemia (CML) is a clonal hematopoietic malignancy driven by the BCR::ABL1 fusion oncoprotein. The development of tyrosine kinase inhibitors (TKIs) has deeply increased long-term survival of CML patients. Nonetheless, one patient out of four will switch TKI off owing either to drug intolerance or resistance partly due to amplification or mutations ofBCR::ABL1oncogene and alteration of ATP-binding cassette (ABC) transporters. Increasing evidence suggests an involvement of the microRNA miR-495-3p in cancer-associated chemo-resistance throughmultidrug resistance 1(MDR1) gene which encodes an ATP-dependent efflux pump. Our study aimed at investigating the potential role of miR-495-3p in CML TKI chemo-sensitivity and determining the underlying molecular circuitry involved. We first observed thatmiR-495-3pexpression was lower in BCR::ABL1 expressing cellular modelsin vitro. Notably, loss-of-function experiments showed increased proliferation associated with a decreased number of non-dividing cells (G0/G1) and resistance to Imatinib. Conversely, our data showed thatmiR-495-3poverexpression hindered leukemic cell growth and TKI resistance even in Imatinib-resistant T315I-mutant cells as well as drug efflux activity throughMDR1regulation. To further investigate the role of miR-495-3p in CML patients, we found that predicted miR-495-3p targets were upregulated in patients in blast crisis involved in protein phosphorylation and associated with the worst prognosis. Taken together, our results demonstrate that down-regulation ofmiR-495-3pexpression is important in the malignant phenotype of CML and TKI resistance mechanisms, which could be a useful biomarker and a potential therapeutic target to eradicate CML.MeSH termsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effectsATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*Blast Crisis / pathologyCell Line, TumorCell Proliferation / drug effects*Cell Survival / drug effectsDrug ResistanceGenes, MDRImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMicroRNAs / geneticsMicroRNAs / physiology*HIGHLIGHTSmiR-495-3p inhibits leukemic cell growth and is downregulated in BCR::ABL1 expressing cell linesmiR-495-3p modulates response to TKI treatment including in UT7 cells expressing T315IOverexpression of miR-495-3p leads to a decrease ofMDR1and drug efflux activityBioinformatics analyses reveal that MiR-495-3p target genes are upregulated in blast crisis
Linking social media marketing efforts with customer brand engagement in driving brand loyalty
Authors: Aljuhmani Hasan Yousef , Elrehail Hamzah , Bayram Pelin , Samarah Tariq 
Published: October 2022

PurposeThis study explores some central questions related to the connections between social media marketing efforts (SMMEs) and brand loyalty by seeking to understand the mediating role of social media customer brand engagement (CBE) in the airline context.Design/methodology/approachThe research model was examined empirically by targeting 360 consumers who follow Royal Jordanian Airlines on Facebook pages. Structural equation modeling (SEM) was used to analyze the data collected.FindingsUsing the Stimulus–Organism–Response (S–O–R) theory and customer engagement model as the theoretical foundations, this study confirms that SMMEs are a strong predictor and play a vital role in developing and building social media customer engagement and brand loyalty. This study also found that the cognitive aspect of CBE is a key driver in enhancing brand loyalty. Furthermore, cognitive social media CBE positively mediated the relationship between SMMEs and brand loyalty. Contrary to expectations, emotional CBE had no mediating effect on the relationship between SMMEs and brand loyalty.Originality/valueThis study contributes to CBE literature by adding SMMEs as antecedents. In addition, the findings of this study add the mediation effect of the cognitive component of customer engagement, through which SMMEs influence brand loyalty.
FDI and cities: network dynamics in cleantech innovation
Authors: Turkina Ekaterina , Sultana Nasrin 
Published: October 2022

Purpose
The purpose of this paper is to understand the relationship between foreign direct investment (FDI) and cities and how the relationship between multinational enterprise (MNEs) and local firms facilitates regional cleantech innovation.

Design/methodology/approach
Using a combination of social network analysis, regression analysis and interview analysis, the authors map and analyze a cleantech cluster to investigate the relationship between MNEs and local firms and the resulting effects on cleantech innovation.

Findings
The findings of the paper indicate that FDI plays a crucial role in cities and their local clusters by acting as a broker between a diverse set of actors: firms, institutions, universities, financial and other intermediaries. Additionally, connectedness to MNEs improves local firms’ innovation.

Research limitations/implications
This study is not free of limitations, mainly, because of the aspects that the analysis is based on one city and one cleantech hub. Further research could verify whether the findings of this paper hold in other cities and industries.

Practical implications
The findings, elucidating the connection between MNEs and local firms, as well as MNEs being important brokers in the local system, and the resulting impact, will help policymakers to take appropriate actions and support the local cleantech innovation. It is important to not only attract high-quality FDI into local clusters, but also to create and support collaborations between foreign firms and local actors, because colocation does not automatically leads to positive spillovers and a lot depends on how MNEs are integrated into the local milieu.

Social implications
The present paper argues that FDI plays an important role in local cleantech innovation and it is important to integrate foreign firms in local social networks.

Originality/value
The authors analyze FDI patterns in an emerging industry at the city and local cluster level using a unique database containing the information on relationships between MNEs and local firms, as well as interview data.
A systematic review of measures of employability
Authors: Neroorkar Samiksha 
Published: October 2022

PurposeThe purpose of this paper is to review empirical research on the measurement of employability, conducted in a 23-year period from 2000 to 2022.Design/methodology/approachA systematic and extensive search of the literature was conducted to select a set of studies that fit the inclusion criteria and addressed the research questions. These studies were conducted worldwide and published anytime from 2000 to 2022. The process of data extraction involved a tabulation of common themes across the studies. Thereafter, the data from the studies were analysed and interpreted to arrive at the findings.FindingsThe findings of this paper show variations in the measures of employability with respect to location, data points, domains and indicators of employability applied. Based on the type of indicators of employability applied, the studies can be categorised as those applying subjective indicators, objective indicators or a combination of the two.Research limitations/implicationsThe paper observed that there has been a great focus on measuring employability using subjective indicators. However, in order to help individuals face the unpredictability of fractious labour markets, going ahead, this measure will not be sufficient. Empirical research needs to focus on applying holistic measures of employability combining both subjective and objective indicators.Originality/valueThis paper presents a detailed categorisation of measures of employability. Thereby, the paper provides useful insights to help practitioners choose a suitable measure of employability for future studies. The paper also makes a case for widening the scope of present measures to apply the construct of employability effectively.
Agile methodologies in times of pandemic: acquisition of employment skills in higher education
Authors: Canales-Ronda Pedro , Aragonés-Jericó Cristina 
Published: October 2022

PurposeThis research aims to focus on analysing the opinion of university students on the effects that agile methodologies are having on their education during this time of pandemic that is affecting the normal functioning of on-site universities. Specifically, the authors intend to analyse the effect that different constructs have on the development of their skills for labour markets through the application of agile methodologies in blended learning. Thus, the authors will analyse the effects of intrinsic motivation, the interactivity of the system, the involvement of students, their engagement to these activities and their level of satisfaction with this training process.Design/methodology/approachThe authors conducted research based on the use of agile methodologies applied to higher education. To this end, various activities were designed within different subjects in marketing area. 115 business students were consulted, who valued their experience and the usefulness of this methodology in relation to the improvement of the learning process.FindingsThe results of the research show the usefulness of agile methodologies for university students. In addition, these methodologies allow them to develop certain skills that will be important for labour markets, such as teamwork, motivation and engagement to tasks to be developed.Originality/valueThe main value of this research lies in the application of a methodology from the business environment in higher education and the subsequent analysis of the students' assessment of these agile methodologies in terms of their usefulness for their professional future. Moreover, this application of agile methodologies has been carried out in an unusual environment due to the pandemic situation that has changed the usual development of face-to-face university training towards the application of e-learning methodologies.
Reflection/transmission of plane waves at the interface of an ideal fluid and nonlocal piezothermoelastic medium
Authors: Gupta Vipin , Kumar Rajesh , Kumar Manjeet , Pathania Vijayata , Barak M.S. 
Published: October 2022

Purpose
This paper aims to study the variation of energy ratios of different reflected and transmitted waves by calculating the amplitude ratios.

Design/methodology/approach
This investigation studied the reflection and transmission of plane waves on an interface of nonlocal orthotropic piezothermoelastic space (NOPHS) and fluid half-space (FHS) in reference to dual-phase-lag theory under three different temperature models, namely, without-two-temperature, classical-two-temperature, and hyperbolic-two-temperature with memory-dependent derivatives (MDDs).

Findings
The primary (P) plane waves propagate through FHS and strike at the interface x3 = 0. The results are one wave reflected in FHS and four waves transmitted in NOPHS. It is noticed that these ratios are observed under the impact of nonlocal, dual-phase-lag (DPL), two-temperature and memory-dependent parameters and are displayed graphically. Some particular cases are also deduced, and the law of conservation of energy across the interface is justified.

Research limitations/implications
According to the available literature, there is no substantial research on the considered model incorporating NOPHS and FHS with hyperbolic two-temperature, DPL and memory.

Practical implications
The current model may be used in various fields, including earthquake engineering, nuclear reactors, high particle accelerators, aeronautics, soil dynamics and so on, where MDDs and conductive temperature play a significant role. Wave propagation in a fluid-piezothermoelastic media with different characteristics such as initial stress, magnetic field, porosity, temperature, etc., provides crucial information about the presence of new and modified waves, which is helpful in a variety of technical and geophysical situations. Experimental seismologists, new material designers and researchers may find this model valuable in revising earthquake estimates.

Social implications
The researchers may classify the material using the two-temperature parameter and the time-delay operator, where the parameter is a new indication of its capacity to transmit heat in interaction with various materials.

Originality/value
The submitted manuscript is original work done by the team of said authors and each author contributed equally to preparing this manuscript.
Gaining more, producing less: the link between an obese workforce and firm-level productivity
Authors: Mazhar Ummad 
Published: October 2022

PurposeThe health costs associated with obesity are increasing in developed and emerging economies. Particularly important, though remaining underexplored, is the overall impact of health risks associated with being obese and overweight on the productivity of firms in a cross-country setting. The purpose of this paper is to address these issues.Design/methodology/approachThis paper exploits the natural variation in the percentage of obese males in the population as an exogenous health risk randomly distributed across firms in each country.FindingsInvestigating this link for a sample of around 80 emerging countries, the evidence suggests a significant negative effect of health risks on productivity.Research limitations/implicationsThe identification assumptions are checked using different approaches to establish the robustness of the empirical link.Originality/valueThis study helps us understand the microlevel effects of the rising average obesity rate. This knowledge is rare in emerging economies which are facing the highest risks of obesity and cardiovascular diseases associated with it.
The money laundering typologies and the applicability of placement-layering-integration model in undocumented South Asian economies: a case of Pakistan
Authors: Sultan Nasir , Mohamed Norazida 
Published: October 2022

Purpose
This study aims to determine the applicability of the placement-layering-integration model of money laundering (ML) in the South Asian context with emphasis on Pakistan by analysing different ML typologies.

Design/methodology/approach
This study applied content analysis in the first step. It explored three primary documents concerning ML typologies: Asia Pacific Group’s yearly reports on ML typologies from 2010 to 2021, the mutual evaluation reports and the National Risk Assessment of Pakistan. In the second step, expert interviews were recorded, and NVivo was used for data management and analysis.

Findings
This study found primary predicate offences: corruption, tax crimes, smuggling and drug and human trafficking. Pakistani launderers often use traditional typologies, including cash smuggling, round-tripping, multiple bank accounts, investment in real estate (in Pakistan and Dubai) and hawala. However, cybercrimes, cyber laundering and trade-based ML are rising. The politically exposed persons are involved in most of the laundering cases.

Originality/value
Rare studies specifically address the south Asian typologies and the limitations of the placement, layering and integration model. Therefore, there is a need to understand the current typologies used in developing, less regulated and undocumented jurisdictions like Pakistan.
Exploring the effect of workplace incivility on job outcomes: testing the mediating effect of emotional exhaustion
Authors: Parray Zahoor Ahmad , Islam Shahbaz Ul , Shah Tanveer Ahmad 
Published: October 2022

PurposeThe main goal of this research study is to look at the mediating effect of emotional exhaustion in the association between workplace incivility and job outcomes (job stress, job satisfaction, and employee turnover intentions).Design/methodology/approachThe authors gathered field data from individuals working in the higher education sector of Jammu and Kashmir to test the proposed study paradigm. A total of 550 respondents reported their perceptions of workplace incivility, emotional exhaustion, and job-related outcomes (job stress, job satisfaction, and employee turnover intention) at Time 1 in the Kashmir division and Time 2 in the Jammu division of Jammu and Kashmir via a two-wave data collection design.FindingsThe findings supported the hypothesized relationships, demonstrating that emotional exhaustion acts as a mediator between workplace incivility and employee job outcomes (job stress, employee job satisfaction, and employee intention to leave).Practical implicationsThe findings of this research study will assist organizations and practitioners in comprehending the implications of workplace incivility and emotional exhaustion, as well as how they positively impact job-related outcomes (employee job stress, turnover intention), and negatively on job satisfaction.Originality/valueThis study adds to existing knowledge on COR theory by suggesting workplace incivility as a stressor and also testing emotional exhaustion as a defense mechanism for determining the effect of workplace incivility on employee job outcomes.
Willing but fearful: resilience and youth entrepreneurial intentions
Authors: Ukil Minhajul Islam , Jenkins Anna 
Published: October 2022

PurposeDespite entrepreneurial intentions being a central and enduring construct in entrepreneurship research, most research on intentions focused on factors that underpin an individual's entrepreneurial intentions. This study extends the emerging literature on fear of failure and resilience to understand how they influence entrepreneurial intentions. The authors do this in a context where job prospects are low, and unemployment is high to understand what potentially prevents educated youth in a developing country from pursuing self-employment.Design/methodology/approachThis study applies the structural equation modelling (SEM) using AMOS 25 to test the hypotheses on a sample of 238 third- and fourth-year Bangladeshi students facing an important career decision. A replication study is also conducted with an additional sample (n = 209) to verify the robustness of the findings, using a different measurement of resilience and a different analysis method – partial least square (PLS)-SEM in Smart-PLS 3.FindingsThe study finds support for the mediation model where fear of failure mediates the relationship between resilience and entrepreneurial intentions. The findings suggest that resilience enhances entrepreneurial intentions while also reducing the negative effects of fear of failure on entrepreneurial intentions.Originality/valueThis study contributes to an underexplored area of entrepreneurial intentions literature by exploring how resilience relates to fear of failure and entrepreneurial intentions. The findings demonstrate the importance of resilience through its direct effect on intentions as well as its indirect effect through its influence on fear of failure. The findings have implications for potential entrepreneurs and educational institutions providing training in entrepreneurship.
Sustainable green technology for adaptation of circular economy to valorize agri-food waste: celery root peel as a case study
Authors: Aşkın Uzel Ruhan 
Published: October 2022

PurposeOne of the popular fields to replace linear economy approach with the sustainable circular approach is the valorization of agri-food waste and by-products by using green methods. Celery peel contains essential nutrients as much as celery root. This study aims to propose a novel framework for investigation of celery root peel waste, which has high nutritional value and is beneficial for healthy nutrition, valorization potential to re-formulate ayran (a traditional Turkish drink).Design/methodology/approachSustainable green extraction/distillation methods were applied to the celery root peel material to obtain water soluble extracts to be used in formulation of traditional Turkish drink “Ayran”.FindingsAs a result of the study, a new functional fermented drink derived from traditional drink ayran was obtained by using celery root peel extract. In addition to the positive characteristic properties of samples in terms of physical, chemical, microbiological and sensory parameters, it was observed that it increased the shelf life by at least 50% compared to the drink from which it was derived.Originality/valueSeveral studies focused the valorization of food waste materials; however, to the best of the author’s knowledge, no study has been taken an approach for using green methods to add additional properties to traditional foods by using celery root peel extracts. Therefore, the study is a remarkable contribution to the circular economy and is a role model for further studies.