bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Rehabilitation Referral Among Cardiovascular Surgical Patients
Authors: Gómez González Laura , Supervia Marta , Medina-Inojosa José R. , Smith Joshua R. , López Blanco M. Esther , Miranda Vivas M. Teresa , López-Jiménez Francisco , Arroyo-Riaño M. Olga 
Published: May 2022

ObjectiveCardiovascular disease (CVD) continues to be the leading cause of mortality globally. Cardiac rehabilitation (CR) programs act by modifying the evolution of CVD and mortality; however, CR programs are under-used. The aim was to determine the profile of patients that received rehabilitation after cardiac surgery.Patients and MethodsA retrospective observational study was conducted from January 2017 to December 2017 at a single center. The study sample was chosen among patients admitted to the Intensive Care Unit of the Hospital Gregorio Marañón/Gregorio Marañón General University Hospital. Socio-demographic and clinical variables were collected.ResultsIn the present study, 336 patients underwent cardiac surgery of which 63.8% were men and 87.1% had ≥1 cardiovascular risk factors. Of the total cohort, 24.7% were operated for ischemic heart disease, 47.9% valvulopathy, 11% underwent combined surgery, 3.6% cardiac transplantation, 6.5% aneurysms, and 3.9% congenital disease. In-hospital respiratory rehabilitation was prescribed to all patients. Only 4.8% of the patients received motor rehabilitation and 13.8% were referred to CR. We found higher referral rates among patients with more cardiovascular risk factors, &lt;65 years of age, and those undergoing coronary surgery and heart transplantation. Age, ischemic heart disease, and overweight were independent predictors of CR referral.ConclusionThe benefit of CR programs after cardiac surgery is widely described; however, the referral rate to CR remains low. It is crucial to optimize referral protocols for these patients.
Cohort Study Examining the Association of Optimal Blood Pressure Control at Entry With Infrarenal Abdominal Aortic Aneurysm Growth
Authors: Thomas Manapurathe Diana , Moxon Joseph Vaughan , Krishna Smriti Murali , Quigley Frank , Bourke Michael , Bourke Bernard , Jones Rhondda E. , Golledge Jonathan 
Published: May 2022

Background and AimThe benefit of controlling cardiovascular risk factors in slowing the progression of small abdominal aortic aneurysm (AAA) is controversial. This study investigated the association of optimal blood pressure control at entry with the growth of small AAA.Methods and ResultsA total of 1,293 patients with initial AAA diameter &lt;50 mm were followed by a median 5 (inter-quartile range, IQR, 3–7) ultrasound scans for a median of 3.6 years (IQR 1.8, 5.3). Optimal blood pressure control was defined as blood pressure ≤140/90 mmHg at recruitment. The association of optimal blood pressure control at entry with AAA growth was assessed using linear mixed effects models adjusted for established risk factors of AAA growth and factors which were unequally distributed among the blood pressure groups. Optimal blood pressure control at entry was not significantly associated with AAA growth. In the risk factor adjusted model the mean difference in AAA growth between blood pressure groups was 0.04 mm/year (95% CI −0.20, 0.13; p = 0.65). The results were similar in sensitivity analyses excluding outliers or focused on systolic or diastolic blood pressure alone.ConclusionsThis observational study suggests that optimal blood pressure control at entry is not associated with slower AAA growth.
Middle Miocene-Pleistocene Magneto-Cyclostratigraphy from IODP Site U1501 in the Northern South China Sea
Authors: Shi Meinan , Wu Huaichun , Ferré Eric C. , Satolli Sara , Fang Qiang , Nie Yunfeng , Qin Yuhe , Zhang Shihong , Yang Tianshui , Li Haiyan 
Published: May 2022

Site U1501 of International Ocean Discovery Program (IODP) Expedition 368 locates on a broad regional basement high in the northern margin of the South China Sea (SCS). This study refines the chronostratigraphy of the upper 160 m sedimentary succession from Hole U1501C using paleomagnetic measurements and cyclostratigraphic analysis on the Natural Gamma Radiation (NGR) data. Rock magnetic analysis displays that the magnetic signal of the sediments is mainly carried by single-domain (SD) and multi-domain (MD) magnetite. A total of 12 geomagnetic reversals are identified and correlated to the geomagnetic polarity time scale (GPTS) in Geologic Time Scale 2020 (GTS 2020), combining biostratigraphic data and planktonic foraminiferal oxygen records. The Milankovitch cycles of 405-kyr long orbital eccentricity, ∼100-kyr short orbital eccentricity, and obliquity cycles are identified in the NGR profile. A 15.54 Myr astronomical time scale is constructed by tuning the short eccentricity cycles filtered from the NGR profiles to the La2010 astronomical solution with the constraints of the magnetostratigraphic results, biostratigraphic age datum and planktonic foraminiferal oxygen records. This new high-resolution age model provides a new temporal constraint on the tectonic and paleoenvironmental evolution in the South China Sea.
Interfacial Behavior of the Steel–UHPC Composite Deck With Toughened Epoxy Bonding
Authors: Jiang Jinlong , Leng Jingchen , Zhang Jiangtao , Guo Jincen 
Published: May 2022

Using traditional stud connectors to connect the ultra-high-performance concrete layer and steel deck is detrimental to the construction speed and fatigue performance of the composite structure. Connecting the steel–UHPC interface with toughened epoxy bonding is a potential alternative to avoid this issue. To explore whether the toughened epoxy bonding interface can reduce the amount of bridge deck studs or even cancel the studs, a numerical simulation was conducted in this paper. The non-toughened epoxy bonding interface, the toughened epoxy bonding interface, a few studs + toughened epoxy bonding interface, and the full stud connection interface were designed to study the interfacial behavior of the steel–UHPC composite deck. Moreover, the constitutive model of the toughened epoxy bonding interface is verified through the direct shear test and compression-shear test. The results show that the maximum interface shear stress of the toughened epoxy bonding interface is 0.61 MPa under the standard wheel load, which is 20.78% lower than that of the non-toughened epoxy bonding interface. Under the overload, the interface failure of the toughened epoxy bonding interface is more concentrated and exhibits a smaller damage area compared with the non-toughened epoxy bonding interface. When the interface defect is 5%, the toughened epoxy bonding interface only has a few interface damages, exhibiting good defect tolerance. Compared to the traditional full stud connection interface, the interface shear stress in the few studs + toughened epoxy bonding interface is more uniform, which avoids the stress concentration in the root of studs, and the studs’ average stress is significantly reduced by 63.21%. It is verified that using the toughened epoxy bonding interface can significantly reduce the amount of studs.
Alterations of Lysine Acetylation Profile in Murine Skeletal Muscles Upon Exercise
Authors: Liang Dehuan , Chen Cheng , Huang Song , Liu Sujuan , Fu Li , Niu Yanmei 
Published: May 2022

ObjectiveRegular exercise is a powerful tool that enhances skeletal muscle mass and strength. Lysine acetylation is an important post-translational modification (PTM) involved in a broad array of cellular functions. Skeletal muscle protein contains a considerable number of lysine-acetylated (Kac) sites, so we aimed to investigate the effects of exercise-induced lysine acetylation on skeletal muscle proteins.MethodsWe randomly divided 20 male C57BL/6 mice into exercise and control groups. After 6 weeks of treadmill exercise, a lysine acetylation proteomics analysis of the gastrocnemius muscles of mice was performed.ResultsA total of 2,254 lysine acetylation sites in 693 protein groups were identified, among which 1,916 sites in 528 proteins were quantified. The enrichment analysis suggested that protein acetylation could influence both structural and functional muscle protein properties. Moreover, molecular docking revealed that mimicking protein deacetylation primarily influenced the interaction between substrates and enzymes.ConclusionExercise-induced lysine acetylation appears to be a crucial contributor to the alteration of skeletal muscle protein binding free energy, suggesting that its modulation is a potential approach for improving exercise performance.
An Initial Evaluation of Human Plasma cMLC-1: A Potential Protein Biomarker for Trastuzumab-Induced Cardiotoxicity, Breast Cancer Screening and Progression
Authors: Yu Ling , Allen Read , Jia Lin , Sun Ting , Isakoff Steven J. , Scherrer-Crosbie Marielle , Kehlmann Allison M. , Zheng Hui , Ly Amy , Walmsley Charlotte S. , Hesler Katherine , Varasteh Ava N. , Pinto Christopher J. , McLoughlin Daniel E. , Wu Wenjin , Wang Xinhui 
Published: May 2022

BackgroundTrastuzumab is a targeted therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, trastuzumab-induced cardiotoxicity (TIC) has been reported when trastuzumab is administered to patients as a single agent or combined with anthracycline. Currently no means for detecting the early onset of TIC such as a protein biomarker is available. In this regard and based on promising results from a preliminary animal study, the potential of cardiac myosin light chain 1(cMLC-1) as a biomarker to predict TIC, screen patients for breast cancer and monitor tumor progression in breast cancer patients was evaluated.MethodsArchived plasma samples collected before and after trastuzumab treatment at various fixed time points from 15 HER2+ patients with or without cardiotoxicity, recently collected plasma samples from 79 breast cancer patients (40 HER2+, 39 HER2-), and 46 healthy donors were analyzed for cMLC-1 levels using an enzyme-linked immunosorbent assay (ELISA).ResultsAn elevated plasma cMLC-1 level was found to be associated with TIC in 3 out of 7 (43%) trastuzumab-treated HER2+ breast cancer patients. However, this study provided an opportunity for us to study plasma cMCL-1 levels in breast cancer patients. It was demonstrated that elevated plasma cMCL-1 is associated with breast cancer. The cutoff cMLC-1 concentration is estimated to be 44.99 ng/mL with a sensitivity of 59.49% (95%CI: 48.47%-69.63%) and specificity of 71.74% (95%CI: 57.45% -82.68%). We also found a noticeable but not significantly more elevated plasma cMCL-1 level in HER2- than in HER2+ breast cancer patients with the given sample sizes. As a result, improved sensitivity of 79.49% (95%CI: 64.47%-89.22%) with the specificity of 63.04% (95%CI:48.60%-75.48%) were obtained for cMLC-1 to predict HER2- breast cancer with the cutoff at 37.17 ng/mL. Moreover, this study determined that cMLC-1 level was significantly higher in patients with metastatic breast cancer than in patients with non-metastatic breast cancer.ConclusionsWhile the analysis of cMLC-1 levels in the plasma of a limited number of trastuzumab-treated HER2+ breast cancer patients failed to fully support its identification as a blood protein biomarker for predicting TIC, additional analyses of plasma cMLC-1 levels did significantly establish its correlations with breast cancer and disease progression. Our findings shed light on and filled, to some extent, the gap of knowledge of the potential of cMLC-1 as a blood protein biomarker for screening breast cancer and monitoring disease progression of breast cancer.
Feeding/Eating Problems in Children Who Refrained From Treatment in the Past: Who Did (Not) Recover?
Authors: Dumont Eric , Jansen Anita , Duker Pieter C. , Seys Daniel M. , Broers Nick J. , Mulkens Sandra 
Published: May 2022

BackgroundYoung children with disordered feeding may be at increased risk for problematic eating in the future. This retrospective study attempts to identify predictors of later feeding problems.ObjectivesChildren (N = 236) with disordered feeding, who refrained from behavioral treatment after consultation at a tertiary treatment center for feeding and eating problems were followed-up after, on average, 6 years and 3 months (timepoint 2).MethodLogistic regressions were carried out with characteristics taken at intake (timepoint 1)—sex, pre/dysmaturity, gastro-intestinal disease, history of age-adequate feeding, syndrome/developmental impairment, autism spectrum disorder, comorbidity, age, and several variables of a restrictive- and selective food intake—and duration between timepoint 1 and 2, as predictor variables, and age-appropriate food intake at t2 as the dependent variable.ResultsDespite improvement over time, 63% did not reach an age-adequate food intake at t2. Predictors of age-inadequate food intake were: (a) older age; (b) sex (male), (c) longer duration between timepoint 1 and timepoint 2; (d) autism spectrum disorder; (e) selective texture choices and (f) lack of varied nutritional intake.ConclusionThis study shows that most untreated young children's feeding problems do not improve over years. Besides the advice to seek help at an early age, it seems especially recommended to treat (male) children with autism spectrum disorder and selective feeding patterns.
A Culture-Based Strategy Is More Cost Effective Than an Empiric Therapy Strategy in Managing Pediatric Helicobacter pylori Infection
Authors: Hung Chi-Wen , Chen Solomon Chih-Chen , Ku Li-Jung Elizabeth , Sheu Bor-Shyang , Yang Yao-Jong 
Published: May 2022

BackgroundHelicobacter pylori infection is a major cause of peptic ulcers and gastric cancer. This study aimed to compare the eradication rate and essential costs of culture-based and empiric therapy strategies in treating pediatric H. pylori infection.MethodsWe retrospectively enrolled patients aged &lt;18 years with a diagnosis of H. pylori infection who received esophagogastroduodenoscopy at two medical centers in southern Taiwan from 1998 to 2018. Patients with positive cultures and minimum inhibitory concentration test results were allocated to a culture-based strategy, and those with negative cultures or without culture as an empiric therapy strategy. We collected demographic data and eradication rates, and calculated the total essential costs of treating a hypothetical cohort of 1,000 pediatric patients based on the two strategies.ResultsNinety-six patients were enrolled, of whom 55 received a culture-based strategy and 41 received an empiric therapy strategy. The eradication rates with the first treatment were 89.1 and 75.6% in the culture-based and empiric therapy strategy, respectively. There were no significant differences in age, sex, and endoscopic diagnosis between the two strategies. For every 10% increase in those receiving a culture-based strategy, the total cost would have been reduced by US$466 in a hypothetical cohort of 1,000 patients. For every 10% increase in successful eradication rate, the total cost was reduced by US$24,058 with a culture-based strategy and by US$20,241 with an empiric therapy strategy.ConclusionsA culture-based strategy was more cost effective than an empiric therapy strategy in treating pediatric H. pylori-infected patients.
Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer
Authors: Liang Hanzhi , Zhu Yue , Zhao Zhiyuan , Du Jintong , Yang Xinying , Fang Hao , Hou Xuben 
Published: May 2022

Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g., R-Roscovitine) are important scaffolds in the development of CDK inhibitors. Herein, we designed a new series of 2-aminopurine derivatives based on the fragment-centric pocket mapping analysis of CDK2 crystal structure. Our results indicated that the introduction of polar substitution at the C-6 position of purine would be beneficial for CDK2 inhibition. Among them, compound 11l showed good CDK2 inhibitory activity (IC50 = 19 nM) and possessed good selectivity against other CDKs. Further in vitro tests indicated that compound 11l possesses anti-proliferation activity in triple-negative breast cancer (TNBC) cells. Moreover, molecular dynamics simulation suggested the favorable binding mode of compound 11l, which may serve as a new lead compound for the future development of CDK2 selective inhibitors.
Restorative Retelling for Processing Psychedelic Experiences: Rationale and Case Study of Complicated Grief
Authors: González Débora , Aixalà Marc B. , Neimeyer Robert A. , Cantillo Jordi , Nicolson Donald , Farré Magi 
Published: May 2022

RationaleMany psychedelic experiences are meaningful, but ineffable. Engaging in meaning-making regarding emerging symbolic content and changing previous schemas have been proposed as mechanisms of change in psychedelic therapy.ObjectiveFirstly, we suggest the implementation of a Restorative Retelling (RR) technique to process and integrate the psychedelic experience into autobiographical memory, in a way that fosters meaning-making. We also show how ayahuasca has the potential to evoke key psychological content in survivors, during the process of grief adjustment following the death of a loved one.MethodsThe rationale for the implementation of RR to process psychedelic experiences and a case study of a woman suffering from Complicated Grief (CG) after her mother’s suicide are presented.ResultsEvaluations conducted before the ayahuasca experience and after RR suggest the effectiveness of ayahuasca and RR in reducing symptoms of CG and psychopathology.ConclusionThis case report illustrates an effective adaptation of the RR technique for processing the psychedelic experience. The significance of the study and its limitations are discussed.
Neural Effects of Cognitive Behavioral Therapy in Psychiatric Disorders: A Systematic Review and Activation Likelihood Estimation Meta-Analysis
Authors: Yuan Shiting , Wu Huiqin , Wu Yun , Xu Huazhen , Yu Jianping , Zhong Yuan , Zhang Ning , Li Jinyang , Xu Qianwen , Wang Chun 
Published: May 2022

BackgroundCognitive behavioral therapy (CBT) is a first-line psychotherapeutic treatment that has been recommended for psychiatric disorders. Prior neuroimaging studies have provided preliminary evidence suggesting that CBT can have an impact on the activity of brain regions and functional integration between regions. However, the results are far from conclusive. The present article aimed to detect characteristic changes in brain activation following CBT across psychiatric disorders.MethodWeb of Science, Cochrane Library, Scopus, and PubMed databases were searched to identify whole-brain functional neuroimaging studies of CBT through 4 August 2021. To be included in the meta-analysis, studies were required to examine functional activation changes between pre-and post-CBT. The included studies were then divided into subgroups according to different task paradigms. Then, an activation likelihood estimation algorithm (ALE) was performed in the different meta-analyses to identify whether brain regions showed consistent effects. Finally, brain regions identified from the meta-analysis were categorized into eight functional networks according to the spatial correlation values between independent components and the template.ResultsIn total, 13 studies met inclusion criteria. Three different meta-analyses were performed separately for total tasks, emotion tasks, and cognition tasks. In the total task ALE meta-analysis, the left precuneus was found to have decreased activation. For the cognition task ALE meta-analysis, left anterior cingulate (ACC) and left middle frontal gyrus (MFG) were found to have decreased activation following CBT. However, the emotion task ALE meta-analysis did not find any specific brain regions showing consistent effects. A review of included studies revealed default mode network (DMN), executive control network (ECN), and salience network (SN) were the most relevant among the eight functional networks.ConclusionThe results revealed that the altered activation in the prefrontal cortex and precuneus were key regions related to the effects of CBT. Therefore, CBT may modulate the neural circuitry of emotion regulation. This finding provides recommendations for the rapidly developing literature.
Compulsive Sexual Behavior Online and Non-online in Adult Male Patients and Healthy Controls: Comparison in Sociodemographic, Clinical, and Personality Variables
Authors: González-Bueso Vega , Santamaría Juan José , Caro-Pérez Oriol , Fernández Daniel , Baño-Alcazar Marta , Jiménez-Murcia Susana , Håkansson Anders , del Pino-Gutiérrez Amparo , Ribas Joan 
Published: May 2022

Background and AimsCompulsive sexual behavior (CSB) is characterized by a persistent pattern of failure to control sexual impulses, resulting in repetitive sexual behavior over a prolonged period that causes marked discomfort in personal, family, social, school, work or in other functional areas. The evolution of the worldwide incidence of this disorder warrants further studies focused on examining the characteristics of the affected people. The purpose of this study was to compare online compulsive sexual behavior (when the problematic sexual practices were online) and non-online compulsive sexual behavior (when the problematic sexual practices were in-person) patients (OCSB and non-OCSB, respectively), and healthy controls in terms of sexual behavior, sociodemographic variables and psychopathology and personality characteristics.MethodA sample of 80 CSB male patients consecutively admitted to our Behavioral Addictions Unit and 25 healthy male controls, participated in the study. The CSB group was comprised by 36 online CSB patients (mean age 42.25, SD: 10.0) and 44 non-online CSB patients (mean age 43.5, SD: 11.9). Scores on the Sexual Compulsivity Scale, Temperament and Character Inventory-Revised, Symptom CheckList-90 Items-Revised, State-Trait Anxiety Index, and additional demographic, clinical, and social/family variables related to sexual behaviors between the three groups were compared.ResultsWhen compared with healthy controls, both clinical groups showed higher psychopathology in all measures as well as higher harm avoidance and self-transcendence and lower self-directness and cooperativeness. When comparing OCSB and non-OCSB patients, results showed that non-OCSB patients exhibited higher prevalence of sexually transmitted diseases, higher percentage of homosexual and bisexual orientation and higher scores in anxiety and in sexual impulse control failure.ConclusionBoth online and non-online CSB patients may experience a variety of comorbid psychological and medical problems. Patients with non-OCSB may suffer more consequences that are negative. Therefore, these results should be considered when designing the most convenient therapeutic approach. Whether sexual orientation plays a role in treatment needs and treatment response in CSB, should be further explored in future studies.