bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant-based nano-fertilizer prepared from Paulownia Tomentosa: fabrication, characterization, and application on Ocimum basilicum
Authors: Sohrabi Yousef , Sharifi Kalyani Firouzeh , Heydari Moslem , Yazdani Majed , Omer Khalid M. , Yousefi Ali Reza 
Published: November 2022

Abstract
Background
The use of hazardous and toxic chemical material has become limited by the green synthesis of nano-particles (NPs) from plants and other living organisms. In the current study, a new nano-fertilizer was green synthesized from Paulownia tomentosa leaves and then its effectiveness in alleviation of drought stress in Ocimum basilicum was investigated. Five concentrations of nano-fertilizer (0, 50, 70, 90 and 110 ppm) at three irrigation regimes including 100% of field capacity (IRF100), 75% of field capacity (IRF75), and 50% of field capacity (IRF50) were evaluated. Nano-fertilizers were prepared using the green hydrothermal method.

Results
Based on TEM analyses nanoparticles sizes were 5–8 nm. The results of FTIR appearance indicated the main distinctive peaks of the Paulownia-based nano-fertilizer (NFPs) in the spectrum. In addition, the nitrogen peaks in the XPS spectra indicate that the prepared carbon dots NFPs are nitrogen-doped. Moreover, there are functional groups, such as COOH or OH groups on the surface of Paulownia-based nano-fertilizer (NFPs). The results illustrated that drought stress increased proline (73%), alcohol-soluble carbohydrates (78%), and malondialdehyde (41%) in comparison with normal irrigation; in contrast, soluble proteins (73%), Chlorophyll a (46%), Chlorophyll b (39%), Chlorophyll total (42%), and carotenoid (77%) were reduced in the same condition. The O. basilicum biological yield was reduced in moderate (12.40%) and severe (24.42%) drought stress in comparison with full irrigation conditions (IRF100). Paulownia-based nano-fertilizer (NFPs) caused an increase in soluble proteins and photosynthetic pigments. Application of NFP-90 reduced the production of proline and malondialdehyde, respectively, 51.8% and 30.8% compared to non-application under severe stress conditions, which indicates alleviated the adverse effect of drought stress. The highest biological yield of basil was obtained at a 110 ppm concentration of NFPs.

Conclusion
Overall, results showed that using NPs biosynthesized from Paulownia leaves could be an economically and environmentally friendly method as a nano-fertilizer.

Graphical Abstract
Phase separation and formation of sodium caseinate/pectin complex coacervates: effects of pH on the complexation
Authors: Ardestani Faezeh , Haghighi Asl Ali , Rafe Ali 
Published: November 2022

Abstract
Background
The electrostatic interactions between polysaccharides and proteins are an interesting field in the complex coacervation. PH and mixing ratio have major effect on the complexation and the coacervates structure. Hence, it is necessary to find the optimum pH and mixing ratio of the coacervates as well as understanding the thermal, mechanical, and structural characterization of the coacervates. Thus, structural changes of the complexes of sodium caseinate (NaCas) and high methoxyl pectin as a function of pH (2.00–7.00), biopolymer ratios (1:1, 2:1, 4:1, and 8:1), and total biopolymer concentration (0.1, 0.2, and 0.4% w/v) were evaluated by light scattering and ζ-potential measurements. The phase separation behavior of the NaCas/HMP coacervate and its kinetics turbidity were also investigated via monitoring the turbidity profiles. Moreover, the thermal, rheological and structural behavior of the coacervates was evaluated at the selected pH values.

Results
The highest turbidity, particle size, and viscosity were achieved at pHmax = 3.30 and formation or dissociation around the pHmax was confirmed by particle size and FTIR. The optimum condition for the coacervation of NaCas and HMP was obtained at ratio 4:1 and 0.4% w/v. Thermal and mechanical stability of the NaCas/HMP coacervates was improved at pH 3.30. By increasing the total concentration of biopolymers, the NaCas/pectin ratio shifted to higher pH values. Furthermore, the maximum coacervate yield was achieved at 39.8% w/w at a ratio of 4:1 of NaCas/HMP and a total biopolymer concentration of 0.4% w/v.

Conclusion
Phase separation behavior of the coacervates exhibited the optimum pH in coacervation between NaCas and HMP. Furthermore, the rheological, thermal and structural stability of the coacervates were improved in comparison with the single biopolymers.

Graphical Abstract
Dislocation of a middle lobe torsion-preventing bridging structure with an absorptive sheet and fibrin glue: a case report
Authors: Matsumiya Hiroki , Kuroda Koji , Mori Masataka , Kanayama Masatoshi , Taira Akihiro , Shinohara Shinji , Takenaka Masaru , Tanaka Fumihiro 
Published: November 2022

Abstract
Background
Middle lobe torsion is a rare complication of right upper lobectomy. Middle lobe torsion can be critical; thus, various preventive measures are used.

Case presentation
A 77-year-old man underwent thoracoscopic right upper lobectomy with partial middle resection and S6 segmentectomy for right upper lobe lung cancer located at the confluence of the three lobes and lower lobe lung cancer. Inversion of the middle lobe was observed during lung expansion before chest closure. A bridging structure with an absorptive sheet and fibrin glue was placed in the basal section of the middle lobe under lung expansion to prevent torsion. On postoperative day 1, the patient was tachycardic and was found to have decreased lung field permeability. The patient underwent emergency surgery for suspected middle lobe torsion. Dislocation of the bridging structure between the basal segments of the middle lobe was confirmed, and the middle lobe was deviated cephalad. In addition, pulmonary congestion in S4 due to pressure stenosis of V4 caused by the deviation of the middle lobe was observed, and middle lobe resection was performed. The postoperative course was uneventful.

Conclusions
This case suggested that the reinforcement method with an absorptive sheet and fibrin glue lacked sufficient strength to prevent middle lobe torsion. Stronger fixation should be considered if the middle lobe rotation is thought to be sufficiently strong when the lung is reinflated before chest closure.
Dietary diversity and micronutrient adequacy among women of reproductive age: a cross-sectional study in Southern Thailand
Authors: Puwanant Maneerat , Boonrusmee Sasivara , Jaruratanasirikul Somchit , Chimrung Kanjana , Sriplung Hutcha 
Published: November 2022

Abstract
Introduction
Adequate nutritional intake of both macronutrients and micronutrients is essential for maintaining good health throughout life, particularly for women of reproductive age (WRA). The Minimum Dietary Diversity for WRA (MDD-W), or the sum of dietary diversity, is recommended as a simple indicator to identify at-risk WRA populations. However, there are no studies on the MDD-W among WRA in Thailand.

Objectives
To determine food group diversity, MDD-W, and micronutrient intake of WRA in Southern Thailand.

Participants
From December 2020 to November 2021, 120 healthy, young WRA (average age 33.2 ± 4.5 years) were enrolled.

Methods
A 24-h food record was used to quantitatively and qualitatively assess the food consumed. Dietary diversity was classified into ten food groups. The macronutrients and 15 micronutrients were calculated using the software program INMUCAL, which is the standard program for calculating nutrients in Thai food. The calculated intake of each micronutrient was transformed to the probability of adequacy (PA).

Results
The most common foods consumed were rice, followed by meat, eggs, fruits, and vegetables. Fewer than 40% of the participants consumed beans, dairy products, vitamin A-rich fruits and vegetables, dark green vegetables, and pulses. The average MDD-W score was 5 (range 2–8). The mean caloric intake (1,865 cal/day) was adequate for non-lactating WRA but was approximately 300 kcal/day lower than the recommendation for lactating WRA. Most WRA consumed lower amounts of micronutrients than those recommended. The mean PA (MPA) of the 15 micronutrients was 0.33 (range 0.0–0.9).

Conclusions
Non-pregnant WRA in Songkhla consumed adequate macronutrients but inadequate micronutrients. A nutritional education program regarding the importance of micronutrients should be provided to the public, with special attention to WRA.
Immune-related adverse events in patients with pre-existing autoimmune rheumatologic disease on immune checkpoint inhibitor therapy
Authors: Lusa Amanda , Alvarez Carolina , Saxena Beem Shruti , Schwartz Todd A. , Ishizawar Rumey 
Published: November 2022

AbstractIntroductionImmune checkpoint inhibitors (ICIs) enhance the immune system’s ability to target and destroy cancer cells, but this non-specific immune overactivation can result in immune-related adverse events (irAEs). Patients with underlying autoimmune diseases were excluded from the original ICI clinical trials because of the theoretical risk of irAEs. This study aimed to evaluate the risk of irAEs in patients with pre-existing rheumatologic diseases on ICIs, impact of anti-rheumatic therapy on irAEs, and malignancy outcomes.MethodsWe performed a retrospective chart review of patients with a pre-existing rheumatologic diagnosis receiving ICIs at the University of North Carolina from 2014 to 2019. Risk differences (RD) and asymptotic 95% confidence intervals (95% CIs) using a continuity correction along with odds ratios (OR) and exact 95% CIs were produced between pre-specified risk factors and flares of the underlying rheumatologic disease and/or irAEs. Kaplan–Meier survival estimates for time to unfavorable cancer response between subsets of patients were compared using the log-rank test.ResultsWe identified 45 patients receiving an ICI with an underlying rheumatologic diagnosis, including 22 with rheumatoid arthritis (RA). Overall, 13 patients (29%) had a flare of their autoimmune disease, 20 patients (44%) had a new-onset irAE, and 27 (60%) had either a flare or new-onset irAE. Patients with RA had higher risk of flares compared to those with other rheumatologic disorders (45% vs 13%, RD 32%, 95% CI 2.0–56.8); all RA flares were ≤ grade 2 and treated in the outpatient setting. Concurrent treatment of the rheumatologic disease at the start of ICI therapy was not associated with a reduced risk of flare (OR 0.86, 95% CI 0.19–3.76) or new onset irAE (OR 3.21, 95% CI 0.83–13.6) compared to those not on anti-rheumatic medications. Anti-rheumatic therapy did not impact time to unfavorable malignancy outcome (p = 0.52).ConclusionThe majority of our study cohort experienced a flare or new onset irAE with ICI treatment. Treatment with anti-rheumatic therapy did not prevent disease flares or new onset irAEs, but did not negatively impact malignancy outcomes. Research is needed to determine safe anti-rheumatic therapy options to prevent flares and irAEs that do not interfere with malignancy outcomes.
Phase II study of trastuzumab-pkrb and docetaxel anhydrous combination therapy in recurrent or metastatic salivary ductal carcinomas (KCSG HN18-08/KM11).
Authors: Lee Jiyun , Park Sehhoon , Jung Hyun Ae , Lee Se-Hoon , Seo Seyoung , Kim Sung-Bae , Kim Ji-Won , Lee Keun Wook , Kang Eun Joo , Kim Ju Won , Choi Yoon Ji , Shim Byoung Yong , An Ho Jung , Park Lee Chun , Shin SeongHoon , Kim Jae-Joon , Oh So Yeon , Kim Min Kyoung , Ahn Myung-Ju 
Published: November 2022

6018 Background: Salivary gland cancers (SGCs) are relatively rare, accounting for 1-6% of all neoplasms of the head and neck, have diverse disease course with respect to origin and pathology. Salivary duct carcinoma (SDC) is the most aggressive tumor subtype of primary SGC, showing high rates of local recurrence and distant metastases. In regard to previous studies which reported a high prevalence of HER2 positivity in SDCs, we conducted a single-arm, phase II study to evaluate the antitumor activity and safety of Herzuma (a trastuzumab biosimilar which demonstrated an equivalent efficacy to reference trastuzumab) in combination with docetaxel anhydrous (Nanoxel) in patients with HER2-positive advanced SDCs. Methods: Eligible patients had histologically confirmed HER2-positive (defined as IHC≥2+ and/or FISH HER2/CEN17 ratio ≥2.0) recurrent/metastatic SDC, or subtypes of SGC that were pathologically similar to SDC (excluding ACCs). They received Herzuma (8mg/kg i.v. loading dose, followed by 6mg/kg i.v.) and Nanoxel (75mg/m2 i.v.) every 3 weeks. The primary endpoint was the investigator-assessed objective response rate (ORR) according to RECIST v1.1. Secondary endpoints were overall survival (OS), progression-free survival (PFS), and safety. The calculated sample size was 43 patients for H1 of ORR ≥40%. Safety was evaluated by CTCAE v4.0. Results: A total of 43 patients were enrolled. Patient characteristics included: median age 60 (range 35–81); 86% male; 84% ECOG1; 84% SDC, 9% adenocarcinoma, 2% high grade mucoepidermoid carcinoma, and 5% other subtypes. Confirmed ORR was seen in 67% (95% CI, 52–81). No patient had a complete response as their BOR, 29 (67%) had a partial response, 11 (26%) had stable disease, 1 (2%) had progressive disease, and 2 (5%) were unevaluable. The DCR was 93% (95% CI, 81–99). The median PFS and OS were 8.2 months (95% CI, 6.7–9.7) and 23.3 months (95% CI, 19.9–26.7), respectively. Thirty-eight (88%) patients experienced a treatment-related AE (TRAE), with 15 (35%) patients experiencing ≥grade 3 TRAE including: neutropenia (10), febrile neutropenia (4), anemia (1), sepsis (1), anaphylaxis (1), decreased LVEF (1). There were no treatment-related deaths. Conclusions: The study met the primary endpoint of ORR. Herzuma and Nanoxel combination therapy demonstrated a promising treatment outcome in patients with HER2-positive recurrent/metastatic SDC. Clinical trial information: NCT03614364.
Active percolation in pusher-type microswimmers
Authors: Schwarzendahl Fabian Jan , Mazza Marco G. 
Published: November 2022

Abstract
The aggregation of microorganisms in colonies and biofilms underpins a myriad of biological processes, and has crucial implications in ecology and biomedical sciences. While much of our knowledge of microbial motion is based on single-cell mechanisms or cell-cell interactions, the origin of cooperativity in microbial communities is not yet fully understood. Here, we reveal the existence of a continuum percolation transition in two model suspensions of pusher-type microswimmers: an asymmetric dumbbell and a squirmer model. Clusters of swimmers held together by hydrodynamic forces dynamically aggregate and separate. Using simulations with explicit hydrodynamics and theory, we find that as the microswimmers' filling fraction increases, the cluster size distribution approaches a scale-free form and system-spanning clusters emerge.
A State of Natriuretic Peptide Deficiency
Authors: Nyberg Michael , Terzic Dijana , Ludvigsen Trine P , Mark Peter D , Michaelsen Natasha B , Abildstrøm Steen Z , Engelmann Mads , Richards A Mark , Goetze Jens P 
Published: November 2022

Abstract
Measurement of natriuretic peptides (NPs) has proven its clinical value as biomarker, especially in the context of heart failure (HF). In contrast, a state of partial NP deficiency appears integral to several conditions in which lower NP concentrations in plasma presage overt cardiometabolic disease. Here, obesity and type 2 diabetes have attracted considerable attention. Other factors—including age, sex, race, genetics, and diurnal regulation—affect the NP “armory” and may leave some individuals more prone to development of cardiovascular disease. The molecular maturation of NPs has also proven complex, with highly variable O-glycosylation within the biosynthetic precursors. The relevance of this regulatory step in post-translational propeptide maturation has recently become recognized in biomarker measurement/interpretation and cardiovascular pathophysiology. An important proportion of people appear to have reduced effective net NP bioactivity in terms of receptor activation and physiological effects. The state of NP deficiency both entails a potential for further biomarker development and could also offer novel pharmacological possibilities. Alleviating the state of NP deficiency before development of overt cardiometabolic disease in selected patients could be a future path for improving precision medicine.
Mechanism of Formate Dehydrogenase Catalyzed CO2 Reduction with the Cation Radical of a 2,2′-Bipyridinium Salt Based on a Theoretical Approach
Authors: Miyaji Akimitsu , Amao Yutaka 
Published: November 2022

Abstract
The visible-light driven redox system of an electron donor, a photosensitizer, an electron mediator and formate dehydrogenase from Candida boidinii (CbFDH; EC.1.2.1.2) as a catalyst has received much attention for CO2 reduction to formate. In this system, elucidation of the electron transfer process between the electron mediator and CbFDH is important for improving efficiency of CO2 reduction to formate. 2,2′-Bipyridinium salt (2,2′-BP2+) is a remarkable electron mediator for CbFDH-catalyzed CO2 reduction. Especially, the direct interaction between cation radicals of 2,2′-BPs (2,2′-BP+•s) and CbFDH is a significant factor for the CO2 reduction. By using 1,1′-ethylene-2,2′-bipyridinium salt (DB2+), 1,1′-trimethylene-2,2′-bipyridinium salt (TB2+), 1,1′-tetramethylene-2,2′-bipyridinium salt (QB2+) and 1,1′-dimethyl-2,2′-bipyridinium salt (DM2+), 2,2′-BP+• with a small dihedral angle between the two pyridine rings (DB or TB) accelerates the CbFDH-catalyzed CO2 reduction. This work illuminated the direct interaction of the cation radicals of DB, TB, QB and DM in the substrate-binding site of CbFDH on the basis of a docking-simulated prediction. Moreover, the electron transfer process from the cation radicals of DB, TB, QB and DM to CO2 in the CbFDH was investigated based on the energy of the molecular orbital calculated by density functional theory (DFT). From these results, it can be predicted that efficient CO2 reduction to formate can be achieved by suppressing the three-dimensional structural change between the 2,2′-BP dication and the cation radical in the substrate-binding pocket of CbFDH as much as possible.
Moment Analysis of Solute Permeation Kinetics at an Interface of Mixed Micelles of Anionic and Nonionic Surfactants
Authors: Miyabe Kanji , Aoki Kayoko 
Published: November 2022

Abstract
Solubilization phenomena of neutral solutes into mixed micelles of anionic and nonionic surfactants were studied by means of micellar electrokinetic chromatography (MEKC). MEKC experiments were conducted by using mixed micelles consisting of sodium dodecylsulfate (SDS) and polyoxyethylene sorbitan monolaurate (Tween 20) or monostearate (Tween 60) as pseudo-stationary phases while changing the concentration of SDS-Tween mixed micelles and the molar fraction of Tween 20 or 60 in mixed micelles. Elution peak profiles measured by MEKC were analyzed on the basis of the moment theory to determine the solute partition equilibrium constant (Kp) and the rate constants of solute permeation at the interface of mixed micelles (kin and kout). It seems that the values of Kp, kin, and kout are increased by adding Tween 20 or 60 and that the influence of the addition of Tween 60 on their values is more remarkable than that of Tween 20. It was demonstrated that moment analysis of MEKC data is effective for studying solubilization phenomena of surfactant micelles under the conditions that both immobilization and chemical modification (i.e., fluorescence labeling) of solute and micelles are not required.
Volatility Puzzle: Long Memory or Antipersistency
Authors: Shi Shuping , Yu Jun 
Published: November 2022

The log realized volatility (RV) is often modeled as an autoregressive fractionally integrated moving average model ARFIMA([Formula: see text]). Two conflicting empirical results have been found in the literature. One stream shows that log RV has a long memory (i.e., the fractional parameter d > 0). The other stream suggests that the autoregressive coefficient α is near unity with antipersistent errors (i.e., d < 0). This paper explains how these conflicting empirical findings can coexist in the context of ARFIMA([Formula: see text]) model by examining the finite sample properties of popular estimation methods, including semiparametric methods and parametric maximum likelihood methods. The finite sample results suggest that it is challenging to distinguish [Formula: see text] (ARFIMA([Formula: see text]) with α close to 0 and d close to 0.5) from [Formula: see text] (ARFIMA([Formula: see text]) with α close to unity and d close to –0.5). An intuitive explanation is given. For the 10 financial assets considered, despite that no definitive conclusions can be drawn regarding the data-generating process, we find that the frequency domain maximum likelihood (or Whittle) method can generate the most accurate out-of-sample forecasts.This paper was accepted by Lukas Schmid, finance.Funding: S. Shi acknowledges research support from the Australian Research Council [Project DE190100840]. J. Yu acknowledges financial support from the Ministry of Education–Singapore Tier 2 Academic Research Fund [Project MOE-T2EP402A20-0002] and the Lee Foundation.Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.4552 .
QoT estimation using EGN-assisted machine learning for multi-period network planning
Authors: Müller Jasper , Patri Sai Kireet , Fehenberger Tobias , Griesser Helmut , Elbers Jörg-Peter , Mas-Machuca Carmen 
Published: November 2022

The rapidly growing traffic demands in fiber-optical networks require flexibility and accuracy in configuring lightpaths, for which fast and accurate quality of transmission (QoT) estimation is of pivotal importance. This paper introduces a machine learning (ML)-based QoT estimation approach that meets these requirements. The proposed gradient-boosting ML model uses precomputed per-channel self-channel-interference values as representative and condensed features to estimate non-linear interference in a flexible-grid network. With an enhanced Gaussian noise (GN) model simulation as the baseline, the ML model achieves a mean absolute signal-to-noise ratio error of approximately 0.1 dB, which is an improvement over the GN model. For three different network topologies and network planning approaches of varying complexities, a multi-period network planning study is performed in which ML and GN are compared as path computation elements (PCEs). The results show that the ML PCE is capable of matching or slightly improving the performance of the GN PCE on all topologies while reducing significantly the computation time of network planning by up to 70%.