bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chiral fiber supramolecular hydrogels for tissue engineering
Authors: Wang Xueqian , Feng Chuanliang 
Published: August 2022

AbstractTissue engineering (TE), as a new interdisciplinary discipline, aims to develop biological substitutes for repairing damaged tissues and organs. For the success of tissue regeneration, such biomaterials need to support the physiological activities of cells and allow the growth and maturation of tissues. Naturally, this regulation is achieved through the dynamic remodeling of the extracellular matrix (ECM) of cells. In recent years, chiral supramolecular hydrogels have shown higher application potential in the TE field than traditional polymer hydrogels due to their dynamic noncovalent interactions, adjustable self‐assembly structure, and good biocompatibility. These advantages make it possible to construct hydrogels under physiological conditions with structure and function similar to those of the natural ECM. Meanwhile, the chiral characteristics of hydrogels play an important role in regulating cellular activities such as differentiation, adhesion, and proliferation, which is beneficial for tissue formation. In this review, a brief introduction is presented to highlight the importance of chiral fiber supramolecular hydrogels for TE at first. Afterward, the considerations for chiral supramolecular hydrogel design, as well as the influence of external stimuli on chiral hydrogel construction, are discussed. Finally, the potential application prospects of these materials in TE and the significant contribution made by our group in this field are summarized. This review not only helps to reveal the importance of chiral properties in TE but also provides new strategies for TE research based on chiral bionic microenvironments.This article is categorized under:
Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Biology‐Inspired Nanomaterials > Peptide‐Based Structures
Nanotechnology Approaches to Biology > Cells at the Nanoscale
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Problematic Use of Social Networking Sites Among Adolescents in the Czech Republic Versus Offline Risk Behaviour and Parental Control
Authors: Tomczyk Łukasz , Szotkowski René , Stošić Lazar , Maksimović Jelena , Počuča Milan 
Published: August 2022

AbstractThe Problematic Use (PU) of Social Networking Sites (SNS) is a diagnostic and preventive as well as educational challenge. Problematic Use of new media is currently a phenomenon discussed by psychologists, sociologists, and media educators in the field of diagnosing the scale of the phenomenon, as well as protective factors and risks related to this phenomenon. This text is part of the debate on the scale of SNS among young people, as well as on the role of parents in reducing this phenomenon. The text also juxtaposes issues related to the prediction of PU SNS and risk behaviours in the offline space. The study employed a triangulation of quantitative tools in the form of: frequency of SNS use, parental control online, and scale of psychoactive substance use. Based on the data collected among a group of adolescents in the Czech Republic (N = 531 individuals aged 13–19 years, study year 2018/2019), it was noted that: 1) Almost 75% of adolescents systematically use SNS before bedtime; 2) Every fifth adolescent consumes dinner daily or almost daily accompanied by SNS; 3) Less than a third of respondents use SNS almost continuously; 4) SNS UI indicators are mutually related; however, the relationship is not always strong; 5) Girls have a slightly higher level of PU SNS than boys; 6) Systematic alcohol consumption is a predictor of PU SNS; 7) Parental restriction of Internet use time leads to a reduction in PU SNS among adolescents.
Educational Digital Storytelling: Empowering Students to Shape Their Future
Authors: Parola Anna , Di Fuccio Raffaele , Somma Federica , Miglino Orazio 
Published: August 2022

AbstractEducation digital storytelling (EDS) refers to digital storytelling in education. EDS is often presented as a technology-enhanced learning approach with powerful educational benefits. The use of EDS as a tool to support students to consider and pursue a meaningful life based on their interests, talents, and aspirations is spreading. Due to its nature, EDS could be an optimal tool to create and share digital stories to stimulate career plans. This paper deals with the educational uses of digital storytelling and presents an overview of how EDS can be used to support career guidance. It concludes with a brief description of the NEFELE Erasmus+ project that will implement tangible user interfaces (TUIs) in the classrooms to promote the EDS as a tool for career intervention.
$$ \mathcal{N} $$ = 1 S-fold spectroscopy
Authors: Cesàro Mattia , Larios Gabriel , Varela Oscar 
Published: August 2022

Abstract
We analyse the spectrum of Kaluza-Klein excitations above three distinct families of $$ \mathcal{N} $$
N
= 1 AdS4 solutions of type IIB supergravity of typically non-geometric, S-fold type that have been recently found. For all three families, we provide the complete algebraic structure of their spectra, including the content of OSp(4|1) multiplets at all Kaluza-Klein levels and their charges under the residual symmetry groups. We also provide extensive results for the multiplet dimensions using new methods derived from exceptional field theory, including complete, analytic results for one of the families. All three spectra show periodicity in the moduli that label the corresponding family of solutions. Finally, the compactness of these moduli is verified in some cases at the level of the fully-fledged type IIB uplifted solutions.
Electroweak renormalization based on gauge-invariant vacuum expectation values of non-linear Higgs representations. Part II. Extended Higgs sectors
Authors: Dittmaier Stefan , Rzehak Heidi 
Published: August 2022

Abstract
A recently proposed scheme for a gauge-invariant treatment of tadpole corrections in spontaneously broken gauge theories — called Gauge-Invariant Vacuum expectation value Scheme (GIVS) — is applied to a singlet Higgs extension of the Standard Model and to the Two-Higgs Doublet Model. In contrast to previously used tadpole schemes, the GIVS unifies the gauge-invariance property with perturbative stability. For the Standard Model this was demonstrated for the conversion between on-shell and $$ \overline{\mathrm{MS}} $$

MS
¯

renormalized masses, where the GIVS leads to very moderate, gauge-independent electroweak corrections. In models with extended scalar sectors, issues with tadpole renormalization exist if Higgs mixing angles are renormalized with $$ \overline{\mathrm{MS}} $$

MS
¯

conditions, which is the major subject of this article. In detail, we first formulate non-linear representations of the extended scalar sectors, which is an interesting subject in its own right. Then we formulate the GIVS which employs these non-linear representations in the calculation of the tadpole renormalization constants, while actual higher-order calculations in the GIVS proceed in linear representations as usual. Finally, for the considered models we discuss the next-to-leading-order (electroweak and QCD) corrections to the decay processes h/H → WW/ZZ → 4 fermions of the CP-even neutral Higgs bosons h and H using $$ \overline{\mathrm{MS}} $$

MS
¯

-renormalized Higgs mixing angles with the GIVS and previously used tadpole treatments.
Higgs/amplitude mode dynamics from holography
Authors: Donos Aristomenis , Pantelidou Christiana 
Published: August 2022

Abstract
Second order phase transitions are universally driven by an order parameter which becomes trivial at the critical point. At the same time, collective excitations which involve the amplitude of the order parameter develop a gap which smoothly closes to zero at criticality. We develop analytical techniques to study this “Higgs” mode in holographic systems which undergo a continuous phase transition at finite temperature and chemical potential. This allows us to study the linear response of the system at energy scales of the order of the gap. We express the Green’s functions of scalar operators in terms of thermodynamic quantities and a single transport coefficient which we fix in terms of black hole horizon data.
Impact of dosimetric factors on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients after (chemo)radiotherapy—results from a prospective randomized trial
Authors: Löser Anastassia , Grohmann Maximilian , Finger Anna , Greinert Franziska , Krause Linda , Molwitz Isabel , Krüll Andreas , Petersen Cordula 
Published: August 2022

AbstractPurpose/objectiveTo analyze dose–volume histogram (DVH)-derived data on the exposure of organs at risk with impact on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients at 6 and 12 months after definitive or adjuvant (chemo)radiotherapy.Materials and methodsSixty-one patients were prospectively treated with (chemo)radiotherapy. Prophylactic or reactive gastrostomy tube placement was performed in 41 (67.2%) patients. Dose–volume histogram parameters were obtained for the swallowing apparatus.ResultsMedian follow-up time was 25 (2–34) months. Overall survival was shorter in patients with inlying PEG tubes at 6 and 12 months (log rankp = 0.038 andp = 0.017) after therapy completion. The estimated median time of tube dependency was 6 (95% confidence interval: 2–14) months. After 6 months, 46.5% of patients were tube dependent. After 12 months, this estimated proportion fell to 31.5%. For both time points, the volume to the larynx (in %) receiving at least 50 Gy (larynx V50Gy) exceeding 53% was predictive for long-term tube feeding (6 months:p = 0.041 and 12 months:p = 0.042) being an independent predictor during multivariable analysis. There was no clinical feature influencing tube dependence after 12 months.ConclusionLong-term gastrostomy dependence was found to be strongly associated with an exposure of laryngeal structures (specifically, V50Gy ≥ 53%) during radiotherapy. Consequently, the avoidance of supraglottic as well as glottic structures is warranted.
One-step extraction and determination of 513 psychoactive substances, drugs, and their metabolites from hair by LC–MS/MS
Authors: Musiał Jadwiga , Powierska-Czarny Jolanta , Czarny Jakub , Raczkowski Michał , Galant Natalia , Buszewski Bogusław , Gadzała-Kopciuch Renata 
Published: August 2022

AbstractThe emergence of new psychoactive substances on the market is a significant problem on a global scale. This type of substance in society is associated with many negative consequences, such as traffic accidents, accidents at work, rape, homicide, poisoning, or overdose deaths. The analysis of these substances in biological samples is very important for further legal action and saving lives. Therefore, laboratories face a tremendous challenge in tackling the evolving drug market. The paper describes the optimization of the analytical LC–MS/MS method to identify and determine 513 psychoactive substances in hair samples. A method of chromatographic separation was developed, and the working parameters of the mass spectrometer were selected for each analyte. The method has been validated, and the results are as follows: the limit of quantification of the developed method ranges from 0.025 to 1.25 ng/mg hair. The mean recovery of the tested analytes ranges from 80 to 120%. The achieved coefficient of variation in within-run precision ranged from 1.05 to 19.99%. The results achieved for BIAS are in the range of ± 20%.
Phenolic and colour characteristics of must and wine obtained from red grapes treated by pulsed electric fields. Efficacy of PEF to reduce maceration time in elaboration of red wines
Authors: López-Giral N. , López R. , Santamaría P. , González-Arenzana L. , Garde-Cerdán T. 
Published: August 2022

AbstractPulsed electric fields effect was studied on the physico-chemical and general phenolic composition as colour characteristics and stilbene content in must and wine. For this purpose, a continuous pulsed electric fields equipment was used to treat three red grape varieties of DOCa Rioja. Graciano, Tempranillo and Grenache wines from these grapes were elaborated with different maceration times, 2 days in the untreated sample (control) and the PEF-treated sample (PEF), and normal maceration time in another untreated sample (control-NM). Parameters as colour intensity, anthocyanin content, total polyphenol index and tannin content showed no differences between the PEF sample with 2 days of maceration and the control-NM sample, except in the case of Tempranillo wines. Total stilbenes, trans-resveratrol and trans-piceid of Graciano wines elaborated from PEF samples showed a higher concentration than the control wines. Alternatively, PEF wines and control-NM wines showed no differences between them. Tempranillo variety wines presented no differences between the three types of samples. In the Grenache variety, only trans-piceid levels showed differences between control and PEF wines. Moreover, relationship between must and wine characteristics was evaluated and compared between different samples. The trend lines obtained for the CI, TPI and AC parameters for samples of Graciano, Tempranillo and Garnacha indicate that the initial content of compounds extracted significantly affected the days of maceration necessary to obtain the appropriate wine. The results obtained increase the knowledge of pulsed electric fields as a technology available for use in the winery to elaborate red wines with reduced maceration time.
Comparison of online health information between different digital platforms for pelvic organ prolapse
Authors: Hüsch Tanja , Ober Sita , Haferkamp Axel , Naumann Gert , Tunn Ralf , Saar Matthias , Kranz Jennifer 
Published: August 2022

Abstract
Purpose
To identify differences in the content and quality of online health information for pelvic organ prolapse (POP) presented in social media and digital search engines to sustainably enhance patient guidance for adequate platforms for seeking online health information on POP.

Methods
The platforms Google search, Facebook, Instagram, LinkedIn, and YouTube were searched for the keyword “pelvic organ prolapse”. Results were categorized as useful, misleading, advertising, and personal experience. Data were categorized into healthcare professionals, professional organisations, industry, patients, and individuals. The readability score and Health On the Net (HON) code seal were analyzed for Google. Descriptive and univariate analysis was performed.

Results
The source with the highest quantity of useful content was YouTube whereas LinkedIn included mostly advertisement and misleading content. YouTube and Google provided the greatest variety of health information. Social media platforms identified emotional distress and sleep disturbances as a common side effect of POP which is limited considered in clinical practice and provide novel insights of bothersome symptoms related to the disease. The spectrum of different surgical techniques was limited in all platforms. Only 12 (40.0%) were HON-qualified websites with a mean readability score of 10.4 which is considered fairly difficult to read.

Conclusion
Besides Google search, YouTube was identified as a valuable online source for POP information. However, encompassing information of surgical techniques was limited in all platforms. Urogynecological association may contribute to improve patient information by providing online health information which is complete and easy to understand.
Contactless pressure measurement of an underwater shock wave in a microtube using a high-resolution background-oriented schlieren technique
Authors: Yamamoto Shota , Shimazaki Takaaki , Franco-Gómez Andrés , Ichihara Sayaka , Yee Jingzu , Tagawa Yoshiyuki 
Published: August 2022

Abstract
A high-resolution background-oriented schlieren (BOS) technique, which utilizes a high-resolution camera and a microdot background pattern, is proposed and used to measure the pressure field of an underwater shock wave in a microtube. The propagation of the shock wave subsequently reaches a concave water–air interface set in the microtube resulting in the ejection of a focused microjet. This high spatial-resolution BOS technique can measure the pressure field of a shock front with a width as narrow as the order of only $$10^1\,\upmu$$

10
1

μ

m with a peak pressure as large as almost 3 MPa. This significant breakthrough has enabled the simultaneous measurement of the pressure impulse of the shock front and the velocity of the microjet tip. As a result, we have experimentally observed the linear relation between the velocity of the microjet tip and the pressure impulse of the shock front for the cases without secondary cavitation in the liquid bulk. Such relation was theoretically/numerically predicted by Peters et al. (J Fluid Mech 719:587–605, 2013). This study demonstrated the capability of the proposed high-resolution BOS technique as a microscale contactless pressure measurement tool for underwater shock waves and potentially other micro- and nanofluids.

Graphical abstract
A CNN-based surrogate model of isogeometric analysis in nonlocal flexoelectric problems
Authors: Wang Qimin , Zhuang Xiaoying 
Published: August 2022

AbstractWe proposed a convolutional neural network (CNN)-based surrogate model to predict the nonlocal response for flexoelectric structures with complex topologies. The input, i.e. the binary images, for the CNN is obtained by converting geometries into pixels, while the output comes from simulations of an isogeometric (IGA) flexoelectric model, which in turn exploits the higher-order continuity of the underlying non-uniform rational B-splines (NURBS) basis functions to fast computing of flexoelectric parameters, e.g., electric gradient, mechanical displacement, strain, and strain gradient. To generate the dataset of porous flexoelectric cantilevers, we developed a NURBS trimming technique based on the IGA model. As for CNN construction, the key factors were optimized based on the IGA dataset, including activation functions, dropout layers, and optimizers. Then the cross-validation was conducted to test the CNN’s generalization ability. Last but not least, the potential of the CNN performance has been explored under different model output sizes and the corresponding possible optimal model layout is proposed. The results can be instructive for studies on deep learning of other nonlocal mech-physical simulations.
Fast mechanisms linking the Labrador Sea with subtropical Atlantic overturning
Authors: Kostov Yavor , Messias Marie-José , Mercier Herlé , Johnson Helen L. , Marshall David P. 
Published: August 2022

AbstractWe use an ocean general circulation model and its adjoint to analyze the causal chain linking sea surface buoyancy anomalies in the Labrador Sea to variability in the deep branch of the Atlantic meridional overturning circulation (AMOC) on inter-annual timescales. Our study highlights the importance of the North Atlantic Current (NAC) for the north-to-south connectivity in the AMOC and for the meridional transport of Lower North Atlantic Deep Water (LNADW). We identify two mechanisms that allow the Labrador Sea to impact velocities in the LNADW layer. The first mechanism involves a passive advection of surface buoyancy anomalies from the Labrador Sea towards the eastern subpolar gyre by the background NAC. The second mechanism plays a dominant role and involves a dynamical response of the NAC to surface density anomalies originating in the Labrador Sea; the NAC adjustment modifies the northward transport of salt and heat and exerts a strong positive feedback, amplifying the upper ocean buoyancy anomalies. The two mechanisms spin up/down the subpolar gyre on a timescale of years, while boundary trapped waves rapidly communicate this signal to the subtropics and trigger an adjustment of LNADW transport on a timescale of months. The NAC and the eastern subpolar gyre play an essential role in both mechanisms linking the Labrador Sea with LNADW transport variability and the subtropical AMOC. We thus reconcile two apparently contradictory paradigms about AMOC connectivity: (1) Labrador Sea buoyancy anomalies drive AMOC variability; (2) water mass transformation is largest in the eastern subpolar gyre.
Der Rolle der DNA-Schadensantwort bei granulomatösen Erkrankungen
Authors: Fabry Lea A. R. , Triantafyllopoulou Antigoni 
Published: August 2022

ZusammenfassungGranulome sind organisierte Aggregate von Immunzellen, die sich infolge eines persistierenden Stimulus bilden und bei verschiedenen rheumatischen Erkrankungen zu finden sind. Zentraler Bestandteil von Granulomen ist eine Vielzahl unterschiedlicher Makrophagensubtypen. Darunter befinden sich auch multinukleäre Makrophagen, die mehrere Zellkerne aufweisen. Die genauen Mechanismen, welche die Granulomentstehung vermitteln, sind bislang noch nicht vollständig aufgeklärt. Neuere Daten zeigen jedoch, dass die DNA-Schadensantwort eine relevante Rolle bei der Entstehung multinukleärer Makrophagen und damit bei der Bildung von Granulomen spielen könnte.
Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure
Authors: Alcantara Juan M. A. , Sanchez-Delgado Guillermo , Jurado-Fasoli Lucas , Galgani Jose E. , Labayen Idoia , Ruiz Jonatan R. 
Published: August 2022

Abstract
Purpose
Metabolic flexibility (MetF), which is a surrogate of metabolic health, can be assessed by the change in the respiratory exchange ratio (RER) in response to an oral glucose tolerance test (OGTT). We aimed to determine the day-to-day reproducibility of the energy expenditure (EE) and RER response to an OGTT, and whether a simulation-based postcalorimetric correction of metabolic cart readouts improves day-to-day reproducibility.

Methods
The EE was assessed (12 young adults, 6 women, 27 ± 2 years old) using an Omnical metabolic cart (Maastricht Instruments, Maastricht, The Netherlands) after an overnight fast (12 h) and after a 75-g oral glucose dose on 2 separate days (48 h). On both days, we assessed EE in 7 periods (one 30-min baseline and six 15-min postprandial). The ICcE was performed immediately after each recording period, and capillary glucose concentration (using a digital glucometer) was determined.

Results
We observed a high day-to-day reproducibility for the assessed RER (coefficients of variation [CV] < 4%) and EE (CVs < 9%) in the 7 different periods. In contrast, the RER and EE areas under the curve showed a low day-to-day reproducibility (CV = 22% and 56%, respectively). Contrary to our expectations, the postcalorimetric correction procedure did not influence the day-to-day reproducibility of the energy metabolism response, possibly because the Omnical’s accuracy was ~ 100%.

Conclusion
Our study demonstrates that the energy metabolism response to an OGTT is poorly reproducible (CVs > 20%) even using a very accurate metabolic cart. Furthermore, the postcalorimetric correction procedure did not influence the day-to-day reproducibility.
Trial registration NCT04320433; March 25, 2020.