bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Determinants of Health, Race, and Diabetes Population Health Improvement: Black/African Americans as a Population Exemplar
Authors: Hill-Briggs Felicia , Ephraim Patti L. , Vrany Elizabeth A. , Davidson Karina W. , Pekmezaris Renee , Salas-Lopez Debbie , Alfano Catherine M. , Gary-Webb Tiffany L. 
Published: March 2022

Abstract
Purpose of Review
To summarize evidence of impact of social determinants of health (SDOH) on diabetes risk, morbidity, and mortality and to illustrate this impact in a population context.

Recent Findings
Key findings from the American Diabetes Association’s scientific review of five SDOH domains (socioeconomic status, neighborhood and physical environment, food environment, health care, social context) are highlighted. Population-based data on Black/African American adults illustrate persisting diabetes disparities and inequities in the SDOH conditions in which this population is born, grows, lives, and ages, with historical contributors. SDOH recommendations from US national committees largely address a health sector response, including health professional education, SDOH measurement, and patient referral to services for social needs. Fewer recommendations address solutions for systemic racism and socioeconomic discrimination as root causes.

Summary
SDOH are systemic, population-based, cyclical, and intergenerational, requiring extension beyond health care solutions to multi-sector and multi-policy approaches to achieve future population health improvement.
Resolutions of operads via Koszul (bi)algebras
Authors: Tamaroff Pedro 
Published: March 2022

AbstractWe introduce a construction that produces from each bialgebra H an operad $$\mathsf {Ass}_H$$

Ass
H

controlling associative algebras in the monoidal category of H-modules or, briefly, H-algebras. When the underlying algebra of this bialgebra is Koszul, we give explicit formulas for the minimal model of this operad depending only on the coproduct of H and the Koszul model of H. This operad is seldom quadratic—and hence does not fall within the reach of Koszul duality theory—so our work provides a new rich family of examples where an explicit minimal model of an operad can be obtained. As an application, we observe that if we take H to be the mod-2 Steenrod algebra $${\mathscr {A}}$$
A
, then this notion of an associative H-algebra coincides with the usual notion of an $$\mathscr {A}$$
A
-algebra considered by homotopy theorists. This makes available to us an operad $$\mathsf {Ass}_{{\mathscr {A}}}$$

Ass
A

along with its minimal model that controls the category of associative $${\mathscr {A}}$$
A
-algebras, and the notion of strong homotopy associative $${\mathscr {A}}$$
A
-algebras.
University spillovers, absorptive capacities, and firm performance
Authors: Lehmann Erik E. , Menter Matthias , Wirsching Katharine 
Published: March 2022

AbstractThis study investigates the impact of both university spillovers and firms’ absorptive capacities on firms’ financial performance, using a multilevel approach. Considering internal firm characteristics as well as external regional characteristics, our results clearly show that university spillovers do not have a per se stimulating effect. It is the interaction between firms’ absorptive capacities and local university spillovers, which proves to have a positive and significant effect on firms’ economic performance. We further find that there is an optimal level of absorptive capacities, implying that ‘a more the better’ logic does not apply. Our findings give impetus to a call for more comprehensive public policy strategies. Policy makers have to balance the support provided to knowledge producing regional actors such as universities as well as knowledge exploiting actors such as knowledge-based firms to leverage local resources and ultimately create economic value within regional innovation systems by enabling efficient technology transfer processes.
Development of digital organ-on-a-chip to assess hepatotoxicity and extracellular vesicle-based anti-liver cancer immunotherapy
Authors: Wu Guohua , Wu Jianguo , Li Zihan , Shi Shengyu , Wu Di , Wang Xuanbo , Xu Han , Liu Hui , Huang Yixiao , Wang Rending , Shen Jia , Dong Zhihong , Wang Shuqi 
Published: March 2022

AbstractOrgan-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic agents. However, current organ-on-a-chip platforms are limited by a “single pot” design, which inevitably requires holistic analysis and limits parallel processing. Here, we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres, which significantly increased the parallelism over traditional organ-on-a-chip for drug development. Up to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units, allowing for analysis with high consistency and quick response. Our platform displayed evident anti-cancer efficacy at a concentration of 10 μM for sorafenib, and had greater alignment than the “single pot” organ-on-a-chip with a previous in vivo study. In addition, this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50 μg/mL. The successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities, thereby accelerating the joint endeavor to combat cancer.
Graphic abstract
Temperature-mediated regulation of flowering time in Arabidopsis thaliana
Authors: Brightbill C. Maddie , Sung Sibum 
Published: March 2022

AbstractThroughout a plant’s life cycle, temperature plays a major role in development. Regulatory modules use temperature cues to control gene expression, facilitating physiological change from germination to flowering. These regulatory modules control morphological and molecular responses to temperature changes caused by seasonal changes or by temporary fluctuations, providing a versatile plasticity of plants. In this review, we outline how temperature changes affect the regulatory modules that induce and repress flowering, in addition to general temperature regulation. Recent studies have identified several regulatory modules by which floral transition and growth responses are controlled in a temperature-dependent manner. This review will report on recent studies related to floral transition and ambient temperature response.
Worst-Case Analysis of a New Heuristic for the Travelling Salesman Problem
Authors: Christofides Nicos 
Published: March 2022

AbstractAn O(n3) heuristic algorithm is described for solving d-city travelling salesman problems (TSP) whose cost matrix satisfies the triangularity condition. The algorithm involves as substeps the computation of a shortest spanning tree of the graph G defining the TSP and the finding of a minimum cost perfect matching of a certain induced subgraph of G. A worst-case analysis of this heuristic shows that the ratio of the answer obtained to the optimum TSP solution is strictly less than 3/2. This represents a 50% reduction over the value 2 which was the previously best known such ratio for the performance of other polynomial growth algorithms for the TSP.
The Medical Information Scientific Process: Define, Research, Evaluate, Synthesize, and Share (DRESS)
Authors: Albano Dominick , Pragga Farah , Rai Rena , Flowers Teresa , Parmar Prachi , Wnorowski Susan , Hermes-DeSantis Evelyn R. 
Published: March 2022

AbstractMedical information (MI) professionals are primarily responsible for researching and responding to unsolicited requests for information on their company’s product(s). In an effort to set a standard for quality, the Pharma Collaboration for Transparent Medical Information (phactMI) created a code of practice for the provision of medical information to healthcare professionals. This code introduced the term “MI science skills” to describe the expertise required to perform the duties of an MI professional. These skills can be summarized by the acronym DRESS. In order to effectively and efficiently respond to an unsolicited request for information, the MI professional essentially follows five steps: define the question, research the topic, evaluate the evidence, synthesize a response, and share the answer. As this approach mirrors the scientific process for data generation, MI scientist may be a more apt description for this role. This paper explains the rationale behind the term MI scientist and the skills associated with each component of the DRESS approach.
Reflections on the human role in AI policy formulations: how do national AI strategies view people?
Authors: Salo-Pöntinen Henrikki , Saariluoma Pertti 
Published: March 2022

Abstract
Purpose
There is no artificial intelligence (AI) without people. People design and develop AI; they modify and use it and they have to reorganize the ways they have carried out tasks in their work and everyday life. National strategies are documents made to describe how different nations foster AI and as human dimensions are such an important aspect of AI, this study sought to investigate major national strategy documents to determine how they view the human role in emerging AI societies.

Approach
Our method for analyzing the strategies was conceptual analysis since the development of technology is embedded with conceptual ideas of humanity, explicit or implicit, and in addition to deepening analysis of explicit argumentation the method enables the deconstruction and reconstruction of meanings and conceptual relations within the strategies, exposing presumptions and tacit commitments of the writers.

Findings
The analysis of the documents illustrates that the general tendency in national strategies is globally dominantly technology-driven as the state of affairs appears to be creating new technologies. However, various human research points such as usability, user experience, sociotechnical and life-based themes are less well represented. Because national strategies are used to develop innovation processes, we argue that future development of national strategies could be improved by taking human research issues more energetically in the agenda.

Originality
Our study elaborates the current trends in AI-policy discourses and discusses reasons and possibilities for more holistic policymaking, making it a valuable resource for policymakers, researchers, and the larger public.
The origin of smiling, laughing, and crying: The defensive mimic theory
Authors: Graziano Michael S. A. 
Published: March 2022

AbstractWhy do we leak lubricant from the eyes to solicit comfort from others? Why do we bare our teeth and crinkle our faces to express non-aggression? The defensive mimic theory proposes that a broad range of human emotional expressions evolved originally as exaggerated, temporally extended mimics of the fast, defensive reflexes that normally protect the body surface. Defensive reflexes are so important to survival that they cannot be safely suppressed; yet they also broadcast information about an animal's internal state, information that can potentially be exploited by other animals. Once others can observe and exploit an animal's defensive reflexes, it may be advantageous to the animal to run interference by creating mimic defensive actions, thereby manipulating the behaviour of others. Through this interaction over millions of years, many human emotional expressions may have evolved. Here, human social signals including smiling, laughing and crying, are compared component-by-component with the known, well-studied features of primate defensive reflexes. It is suggested that the defensive mimic theory can adequately account for the physical form of not all, but a large range of, human emotional expression.
Feminist Demands and the Problem of Housework
Authors: FORRESTER KATRINA 
Published: March 2022

This article develops an account of demand-making and provides a novel framework for evaluating the demands and strategies of social movements. It explores three features of demands, arguing that they disclose social conditions, create constituencies, and set the horizons of the world that social movements seek to build. It does so by considering two feminist demands: the demand for wages for housework and for the socialization of housework. By revisiting revolutionary feminism in the 1970s, it contrasts two strategic perspectives articulated in debates about housework: what Selma James called the “perspective of winning” and what I call the “perspective of investment,” a strategy for change that sees short-term reforms as investments in long-term transformations. In light of this, I endorse the demand to socialize housework as apt for the contemporary care economy and show how my account of demand-making contributes to the political theory of social movements by clarifying movement demands for “non-reformist reforms,” such as defund the police.
TORT'S HIERARCHY OF PROTECTED INTERESTS
Authors: Murphy John 
Published: March 2022

AbstractIt is widely accepted that tort law operates according to a hierarchy of protected interests. Some commentators suggest that this hierarchy can be put to dispositive uses in cases characterised by a clash of interests held respectively by the claimant and defendant (the inferior interest giving way). Others argue that thinking in terms of a hierarchy of interests sheds light on three unusual aspects of tort law: viz. the existence of torts that are actionable per se, the existence of strict liability torts, and the existence of actions in which injunctive relief is routinely awarded even though compensatory damages are tort law's default remedy. This article tests both claims. It concludes that an intuitively appealing hierarchy of interests can be identified, and that it might well possess dispositive significance all other things being equal. But it also observes that all other things are seldom equal, and that departures from the hierarchy occur for various reasons that can be clearly identified and which should be borne in mind when thinking about its dispositive utility. It also urges caution in making connections between the status of certain interests and the fact that they are protected by torts that are actionable per se, strict liability torts and torts in connection with which injunctions are awarded almost as a matter of course.
Effects of the thermal denaturation degree of a whey protein isolate on the strength of acid milk gels and the dissociation of κ-casein
Authors: Oka Daiki , Ono Wataru , Tamaki Shojiro , Noguchi Tomohiro , Takano Katsumi 
Published: March 2022

AbstractIn this study, the effects of the degree of thermal denaturation of whey protein (WP) added to milk on the dissociation of κ-casein from casein micelles were investigated, since they are related to the strength of acid milk gel and its factors. Acid milk gels were prepared by heating thermally denatured WP isolate (WPI) and undenatured milk mixtures and treating them with glucono-δ-lactone as a coagulant. The strength of these gels was negatively correlated with the WPI denaturation degree and strongly positively correlated with the extent of κ-casein dissociation from casein micelles. This behavior was ascribed to the fact that α-lactalbumin (α-La) and β-lactoglobulin (β-Lg) contained in WPI denatured after heating and engaged in disulfide bond formation with each other. With an increase in the degree of denaturation and disulfide bond formation, the bonding between β-lactoglobulin and κ-casein was suppressed to decrease the amount of κ-casein–WPI complexes. When β-Lg forms SS bonds with α-La, the number of highly reactive, free SH groups decreases, which complicates the formation of SS bridges between β-Lg and κ-casein. Thus, the denaturation degree of WPI largely determined the degree of κ-casein dissociation from casein micelles and, consequently, the strength of acid milk gels. Adding WP to milk increases the strength of acid milk gel, and it can be controlled by changing the degree of thermal denaturation of the WP. Furthermore, it was clarified for the first time that the dissociation of κ-casein from casein micelles influences this effect. Further studies are needed to elucidate the structural features of κ-casein-dissociated micelles.
First isolation and scanning electron microscopy of haptoral sclerites ofMacrogyrodactylus(Monogenea)
Authors: Maduenyane Mpho , Dos Santos Quinton Marco , Avenant-Oldewage Annemariè 
Published: March 2022

AbstractMacrogyrodactylus congolensis(Prudhoe, 1957) is one of six species ofMacrogyrodactylus, all of which are endemic to Africa. This monogenean is a host-specific ectoparasite of the African sharptooth catfish,Clarias gariepinus(Burchell, 1822). It attaches to the host with a posterior haptor armed with sclerites. The specific morphology of sclerites is taxonomically significant and usually studied using light microscopy. The aim of the present study was to confirm the identification of macrogyrodactylid parasites using classic morphology (light microscopy of glycerine ammonium picrate mounted specimens) and molecular techniques (18S rDNA, ITS rDNA and cytochrome oxidase subunit 1 (COI) mtDNA). Additionally, the sclerites were accurately described with a technique not previously used for the genus, whereby haptoral sclerites were isolated by removing the encapsulating soft tissue with a digestion buffer and studied with scanning electron microscopy (SEM). Morphology and morphometry of studied specimens corresponded to available data forM. congolensis, confirming the identity of the parasite. All previous descriptions were summarized in a table and discrepancies discussed. Molecular analysis also confirmed the specimens to beM. congolensis, but ITS rDNA and COI mtDNA was more reliable than 18S rDNA in this regard. The isolation of haptoral sclerites and their study using SEM was successful, resolving the morphology of all sclerites. This study provided the first reconstruction of the haptor of aMacrogyrodactylusspecies following SEM analysis, as well as the first mtDNA forM. congolensis. Further study of isolated haptoral sclerites of other macrogyrodactylids is required to determine the full benefits of studying their isolated sclerites.
Phylogeny, species delimitation and ecological and morphological diversity of Characithecium (Monogenoidea: Dactylogyridae)
Authors: Wendt Emília W. , Malabarba Luiz R. , Braga Mariana P. , Boeger Walter A. , Landis Michael , Carvalho Tiago P. 
Published: March 2022

Abstract
Characithecium (Monogenoidea, Dactylogyridae) is a genus containing nine species that live on the gills of a characid clade containing genera Astyanax, Andromakhe, Psalidodon and Oligosarcus (Characiformes, Characidae) in South and Central America. Earlier studies suggest a tight coevolutionary history between these parasites and their hosts mainly due to the phylogenetic proximity between these genera of fish. Hence, this study explores phylogenetic relationships, species limits and extrinsic factors (geography and ecology) explaining parasite prevalence. To understand the evolutionary history of the genus, we constructed a time-calibrated phylogenetic hypothesis, which includes eight of the nine known species of Characithecium sampled from a broad spectrum of host species. The phylogeny supports the monophyly of Characithecium, with its most recent common ancestor dating from the Miocene. Using generalized mixed-yule coalescent and Bayesian Poisson tree process methods, species delimitation analyses suggested fewer species than the proposed delimitation based on morphology alone, recovering four and six entities, respectively. The results indicate that species of Characithecium have wider geographical and host distribution and higher prevalence on Oligosarcus species compared to Astyanax and Psalidodon. Correlation between parasite prevalence and biotic and abiotic traits, based on generalized linear models, indicates that the frequency of occurrence of different species of Characithecium is associated with distinct factors, such as host genus, high altitudes, rivers and streams, and different ecoregions. Our results suggest that species of Characithecium are highly opportunistic, exploring resources in different manner as our data reveal the ability of these parasites to explore a diverse environment of variable biotic (e.g. hosts) and abiotic features.
The Reproduction of Caruso
Authors: Williams Gavin 
Published: March 2022

AbstractFew figures loom larger in the early history of recorded sound than Enrico Caruso. Man and voice are ubiquitous in the making of gramophone markets, and conspicuous, too, as means of scholarly explanation by which a sound medium was born. In sound studies, Caruso has become a cipher for ‘audile technique’ (Jonathan Sterne's coinage), the bodily practices by which listeners came to engage musical media as something for their ears alone. This article inquires after what made Caruso a reproducible person. It portrays him as a singer celebrity deeply involved in his own reproduction through the media of caricature, sculpture, film and opera house. Through analysis of Caruso's productions for New York's Italian diaspora and farther afield, it argues that an ensemble of media meant he was reproduced beyond familiar, cosmopolitan circuits of operatic celebrity. Finally, it shows how politics of celebrity reproduction were transformed following Caruso's death, through the writing of history, into new imaginations and techniques for listening.
The cognate facilitation effect depends on the presence of identical cognates
Authors: Arana Sophie L. , Oliveira Helena M. , Fernandes Ana Isabel , Soares Ana Paula , Comesaña Montserrat 
Published: March 2022

AbstractPrevious research has shown that the direction of the cognate facilitation effect (CFE) can disappear if identical cognate words are removed from the stimulus list while keeping task requirements constant (Comesaña, Ferré, Romero, Guasch, Soares & García-Chico, 2015). These results do not fit well with leading computational models of bilingual word recognition (BIA+, Multilink), according to which there are no top-down influences at early stages of word processing. Influences would be post-lexical in nature and would result from competition at the response level. This study aimed to examine this issue by manipulating stimulus list composition and examining its impact on cognate word recognition. We varied the proportion of identical cognates in the experimental lists with four ratios of identical vs. non-identical cognates (50-50; 25-75; 12-88, and 0-100, respectively). Results showed that the CFE gradually decreases as the proportion of identical cognates also decreases. These findings cannot be explained by mechanisms of response competition, but instead seem to imply a dynamic and language-specific top-down regulation of lexical activation.
The Idea of God and the Empirical Investigation of Nature in Kant’s Critique of Pure Reason
Authors: Spagnesi Lorenzo 
Published: March 2022

AbstractThis article aims to justify the positive role in the empirical investigation of nature that Kant attributes to the idea of God in the Critique of Pure Reason. In particular, I propose to read the Transcendental Ideal section and the Appendix to the Transcendental Dialectic together to see whether they can reciprocally illuminate each other. I argue that it is only by looking at the transcendental deduction of the ideas of reason and the resulting analogical conception of God (which Kant provides in the Appendix) that a fully legitimate positive use of the idea of God can be vindicated.