bluuebunny/crossref_metadata_2025_split huggingface dataset:
SGLBP: Subgraph‐based Local Binary Patterns for Feature Extraction on Point Clouds
Authors: Guo Bao , Zhang Yuhe , Gao Jian , Li Chunhui , Hu Yao 
Published: April 2022

AbstractExtraction for points that can outline the shape of a point cloud is an important task for point cloud processing in various applications. The topology information of the neighbourhood of a point usually contains sufficient information for detecting features, which is fully considered in this study. Therefore, a novel method for extracting feature points based on the topology information is proposed. First, an improved ‐shape technique is introduced, generating two graphs for potential feature detection and neighbourhood description, respectively. Local binary pattern (LBP) is then applied to the subgraphs, thus subgraph‐based local binary patterns (SGLBPs) are generated for encoding the topology of the neighbourhoods of points, which helps to remove non‐feature points from potential feature points. The proposed method can directly process raw point clouds and needs no prior surface reconstruction or geometric invariants computation; furthermore, the proposed method detects feature points by analysing the topologies of the neighbourhoods of points, consequently promoting the effectiveness for tiny features and the robustness to noises and non‐uniformly sampling patterns. The experimental results demonstrate that the proposed method is robust and achieves state‐of‐the‐art performance.
Child well‐being in early childhood education and care during COVID‐19: Child sensitivity in small, fixed groups
Authors: Koch Anette Boye 
Published: April 2022

AbstractThe article explores child well‐being in Danish early childhood education and care (ECEC) during the time of COVID‐19. A phased reopening of Denmark occurred in spring 2020 under strict health guidelines. Two ECEC institutions were followed first‐hand to observe the impact of the pandemic on pedagogy and child well‐being. Observations and interviews were conducted with follow‐up interviews and an online survey a year later. The findings suggest that the pandemic caused pedagogues to work in a more child‐sensitive way with elevated staff/child ratios and children in small, fixed groups; however, child well‐being was not negatively affected, despite the acute situation
Impact of serial measurements of tricuspid annular plane systolic excursion on mortality and morbidity after heart transplantation
Authors: Vishram‐Nielsen Julie K. K. , Nelson Lærke M. , Fan Chun‐Po , Foroutan Farid , Gustafsson Finn , Billia Filio , Ross Heather J. , Alba Ana Carolina 
Published: April 2022

AbstractThe impact of right ventricular (RV) dysfunction on long‐term post‐HTx outcomes remains uncertain. We assessed the impact of serial measurements of Tricuspid Annular Plane Systolic Excursion (TAPSE) on post‐HTx mortality and morbidity. This two‐center retrospective cohort study included consecutive adult HTx recipients (2000–2017). We used multivariable extended hazard regression models to evaluate the association between TAPSE and left ventricular ejection fraction (LVEF), entered as time‐dependent variables, and all‐cause mortality, cardiac allograft vasculopathy (CAV), acute cellular rejection (ACR), and chronic kidney disease (CKD). TAPSE was modelled using cubic splines. We included 485 HTx recipients (9461 TAPSE measurements), median (25th‐ 75th percentile) 19 (10–27) mm; median age was 52 (41–59) years, and 71.3% were male. During a follow‐up of 6.7 (3.0–10.8) years, 92 patients died, 225 had ACR >2R, 234 CAV, and 91 CKD. By multivariable analysis, for each 1‐mm decrease in patients with a TAPSE value <15mm, mortality increased by 22% (P<.001). For the average HTx recipient with a TAPSE of 15mm, 10mm, and 6mm, 1‐year mortality was 3%, 7%, and 17%, and 5‐year mortality was 8%, 20%, and 43%, respectively. Reduced TAPSE was significantly associated with increased CAV but notACR and CKD. A decrease in TAPSE below 15mm represents clinically significant graft dysfunction, warranting close monitoring.
Cross‐functional integration skills: Are business schools delivering what organizations need?
Authors: D'Souza Derrick E. , Bement Danuse , Cory Kenneth 
Published: April 2022

AbstractPractitioner surveys suggest that despite well‐intentioned efforts, undergraduate business programs could better equip students with “soft skills.” This research study focuses on the soft skills associated with cross‐functional integration (CFI), where skill gaps are believed to exist but have not been confirmed. As the first study to specifically characterize and measure CFI skills, we argue that even in the best‐case scenario, a small CFI‐skills gap could persist, and that the primary goal of business programs is to minimize, not eliminate, the gap. We assert that an instrument that measures CFI skills on three dimensions (cross‐functional collaboration, cross‐functional coordination, and cross‐functional communication) provides a critical starting point in the identification and management of the CFI skills gap. We adapt and validate such an instrument, test it with a sample of 160 business students and 160 hiring managers, and find statistically significant gaps at the construct and dimensional level. However, the magnitude of the gaps is not large, suggesting that business schools may be doing a good job of managing the CFI skills gap. Our assessment instrument is a valuable tool for companies that wish to diagnose and address CFI skills challenges.
Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease
Authors: Arefin Samsul , Hernandez Leah , Ward Liam J. , Schwarz Angelina ,   GOING‐FWD Collaborators, Barany Peter , Stenvinkel Peter , Kublickiene Karolina 
Published: April 2022

AbstractBackgroundIndividuals with chronic kidney disease are affected by acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) due to multiple comorbidities and altered immune system. The first step of the infection process is the binding of SARS‐CoV‐2 with angiotensin‐converting enzyme 2 (ACE2) receptor, followed by its priming by transmembrane protease serine 2 (TMPRSS2). We hypothesized that circulating soluble ACE2 levels, as well as the expressions of ACE2 and TMPRSS2 in the microvasculature, are increased in patients with end‐stage kidney disease (ESKD).MethodsA total of 210 participants were enrolled, representing 80 ESKD patients and 73 non‐CKD controls for soluble ACE2, and 31 ESKD and 26 non‐CKD controls for vasculature and fat tissue bioassays. We have assessed ACE2 expression in blood using ELISA and in tissue using immunofluorescence.ResultsSoluble ACE2 levels were higher in ESKD patients compared to controls; however, there is no sex difference observed. In ESKD and controls, soluble ACE2 positively correlated with Interleukin 6 (IL‐6) and C‐reactive protein (CRP), respectively. Similarly, ACE2 tissue expression in the vasculature was higher in ESKD patients; moreover, this higher ACE2 expression was observed only in male ESKD patients. In addition, TMPRSS2 expression was observed in vessels from males and females but showed no sex difference. The expression of ACE2 receptor was higher in ESKD patients on ACE‐inhibitor/angiotensin blocker treatment.ConclusionESKD is associated with increased ACE2 levels in the circulation and pronounced in male vasculature; however, further studies are warranted to assess possible sex differences on specific treatment regime(s) for different comorbidities present in ESKD.
Marine rove beetles in a low‐salinity lake: Cafius pectoralis (Coleoptera: Staphylinidae) prey on beach hopper in brackish water
Authors: Hayashi Masakazu 
Published: April 2022

AbstractA marine rove beetle, Cafius pectoralis (Boheman, 1858), inhabits the coast and is found in seaweed washed ashore on sandy beaches. This species also inhabits Lake Shinji, a brackish lake with low‐salinity, but there is no seaweed or kelp flies in this lake. Cafius pectoralis prefers to prey on beach hoppers, and many hoppers live in Lake Shinji. One rove beetle and one beach hopper were placed together in a container for 24 h. As a control, beach hoppers were placed in similar containers alone for 24 h. While the beach hoppers that were alone all survived, those with rove beetles were all dead after 24 h. Consequently, it is speculated that the beetles feed on beach hoppers and that they have become habituated to the brackish lake.
A Resist‐Accept‐Direct decision‐support tool for walleye Sander vitreus (Mitchill) management in Wisconsin
Authors: Dassow Colin J. , Latzka Alex W. , Lynch Abigail J. , Sass Greg G. , Tingley Ralph W. , Paukert Craig P. 
Published: April 2022

AbstractLarge‐scale modelling and prediction provide insight into general influences of climate change on inland recreational fisheries; however, small‐scale dynamics and local expertise will be key in developing explicit goals for managing recreational fisheries as the climate changes. The resist‐accept‐direct (RAD) framework encompasses the entire decision space managers consider when addressing climate influences in their local system, but to decide whether to resist, accept or direct, managers need tools to understand how specific waterbodies will be influenced by climate change. Here, a decision‐support tool was developed and applied to the walleye recreational fishery in Wisconsin, USA as an example of how to link the RAD framework to real‐world management of a large recreational fishery. The tool and broadscale results described here, indicating a widespread shift away from resist strategies by mid‐century, can be used by managers to inform decisions about whether to resist, accept, or direct for specific walleye populations.
High‐resolution mapping of the global silicate weathering carbon sink and its long‐term changes
Authors: Li Chaojun , Bai Xiaoyong , Tan Qiu , Luo Guangjie , Wu Luhua , Chen Fei , Xi Huipeng , Luo Xuling , Ran Chen , Chen Huan , Zhang Sirui , Liu Min , Gong Suhua , Xiong Lian , Song Fengjiao , Xiao Biqin , Du Chaochao 
Published: April 2022

AbstractClimatic and non‐climatic factors affect the chemical weathering of silicate rocks, which in turn affects the CO2 concentration in the atmosphere on a long‐term scale. However, the coupling effects of these factors prevent us from clearly understanding of the global weathering carbon sink of silicate rocks. Here, using the improved first‐order model with correlated factors and non‐parametric methods, we produced spatiotemporal data sets (0.25° × 0.25°) of the global silicate weathering carbon‐sink flux (SCSFα) under different scenarios (SSPs) in present (1950–2014) and future (2015–2100) periods based on the Global River Chemistry Database and CMIP6 data sets. Then, we analyzed and identified the key regions in space where climatic and non‐climatic factors affect the SCSFα. We found that the total SCSFα was 155.80 ± 90 Tg C yr−1 in present period, which was expected to increase by 18.90 ± 11 Tg C yr−1 (12.13%) by the end of this century. Although the SCSFα in more than half of the world was showing an upward trend, about 43% of the regions were still showing a clear downward trend, especially under the SSP2‐4.5 scenario. Among the main factors related to this, the relative contribution rate of runoff to the global SCSFα was close to 1/3 (32.11%), and the main control regions of runoff and precipitation factors in space accounted for about 49% of the area. There was a significant negative partial correlation between leaf area index and silicate weathering carbon sink flux due to the difference between the vegetation types. We have emphasized quantitative analysis the sensitivity of SCSFα to critical factors on a spatial grid scale, which is valuable for understanding the role of silicate chemical weathering in the global carbon cycle.
Influence of frailty on patient global assessment in rheumatoid arthritis
Authors: Suzuki Mochihito , Asai Shuji , Sobue Yasumori , Ohashi Yoshifumi , Koshima Hiroshi , Okui Nobuyuki , Ishikawa Hisato , Takahashi Nobunori , Terabe Kenya , Kishimoto Kenji , Hattori Kyosuke , Imagama Shiro , Kojima Toshihisa 
Published: April 2022

AimPatient Global Assessment (PtGA; range 0–10 cm) is an important indicator of clinical outcomes, including physical function, in self‐assessment of patients with rheumatoid arthritis (RA). Frailty is a concept that encompasses not only physical, but also mental, psychological and social vulnerability. This study aimed to investigate the influence of frailty on PtGA in patients with RA.MethodsAmong 581 patients with RA who completed a questionnaire survey on frailty between June and August 2020, 559 who completed the Kihon Checklist (KCL; a 25‐item questionnaire with seven domains) were included. The proportion of patients with PtGA ≤1 was compared between the frailty (KCL score ≥8), pre‐frailty (KCL score 4–7) and robust (KCL score 0–3) groups. Factors associated with PtGA ≤1 were examined using multivariate logistic regression models.ResultsOf the 559 patients, 221 (39.5%) had frailty. The proportion of patients with PtGA ≤1 was significantly lower in the frailty group (33.9%) than in the robust (65.4%, P < 0.001) and pre‐frailty (55.7%, P < 0.001) groups. Multivariate analysis revealed that frailty (vs robust, OR 0.37, 95% CI 0.22–0.69), as well as disease duration and tender joint count, were factors independently associated with PtGA ≤1. When each domain of the KCL was examined, activities of daily living, physical strength, isolation and depressive mood were factors associated with PtGA ≤1.ConclusionFrailty affects PtGA in patients with RA. As frailty impacts the physical, mental and social vulnerability aspects of PtGA, a multifaceted approach, including inflammation suppression, is required to improve PtGA in patients with RA. Geriatr Gerontol Int 2022; 22: 399–404.
Spalling degradation of Cr2O3‐Al2O3‐ZrO2 refractories for coal‐water slurry gasifier linings: Role of phosphate
Authors: Sun Honggang , Li Hongxia , Geng Keming , Zhao Shixian , Du Yihao , Yan Shuangzhi 
Published: April 2022

AbstractTwo kinds of high chromia bricks with and without phosphate as gasifier linings were postmortem analyzed during their whole service life. The effect of phosphate on the microstructure and phase composition of refractory sections was analyzed. The dense phosphate enrichment layer was observed between the slag penetration layer and the virgin layer, which was considered to reduce the damage of gasifier lining caused by spalling. Phosphate could decompose and migrate slowly under suitable temperature gradient existing in the bricks in service, which would result in the densification of the microstructure earlier than slag penetration. The phosphate in high chromia bricks reduced frequency of spalling due to penetration, which would lead to the lower early wear rate and longer lifetime.
Sintering and characterization of aluminum titanate ceramics with enhanced thermomechanical properties
Authors: Huang Xuehui , Song Xiaozhan , Yang Na , Chang Yu 
Published: April 2022

AbstractAluminum titanate (Al2TiO5) was synthesized from Al2O3‐TiO2 system by solid‐phase reaction with additives of light magnesium carbonate and SiO2, incorporating with silicon carbide (SiC) particle. The influence of additives on the phase composition, microstructure configuration, sintering, and thermomechanical properties of the developed materials was investigated. The experimental results illustrated that the utilization of additives with applicable contents was conducive to the development of complex microstructures. The microstructures characterized by microcracks matrix together with interlocked grains were identified. The samples incorporating SiC and SiO2 simultaneously displayed exceptional densification properties and microstructure as a result of a SiO2 liquid phase accelerating SiC oxidation. Meanwhile, high flexural strength (41.51 MPa) and low thermal expansion coefficient of 0.485 × 10−6 K−1 (RT‐1000 °C) were detected, encouraging refractory applications with high thermomechanical solicitations.
Fabrication of highly bioactive zirconia ceramics via grain‐boundary activation for dental implants
Authors: Zhang Wenmin , Ke Jinhuan , Qian Guowen , Ye Jiandong 
Published: April 2022

AbstractYttria‐stabilized tetragonal zirconia polycrystal (Y‐TZP) ceramics with outstanding mechanical properties and aesthetic origins are expected to be used in dental implant applications. However, tetragonal zirconia ceramics are not bioactive, which affect the osseointegration and reliability as dental implant materials. Herein, in this study, Y‐TZP ceramics were modified by grain‐boundary activation via coating a bioactive glass (BG) sol with different content on the crystal surfaces of zirconia powder and followed by being gelled, dried, granulated, low‐temperature treated, molded and sintered at 1450°C for 3 h in air. The effects of BG content on the morphology, phase compositions, mechanical properties, in vitro mineralization ability and cell biological properties of the bioactivity modified Y‐TZP ceramics were evaluated. The BG additive did not affect the tetragonal–monoclinic phase transformation of ZrO2. However, the addition of BG decreased the flexural strength of the modified Y‐TZP ceramics compared to that of Y‐TZP. The in vitro mineralization results showed that a homogeneous apatite layer was produced on the surface of the Y‐TZP ceramics when they were immersed in the simulated body fluid for 21 days. The cell response results indicated that the bioactive surface modification of Y‐TZP ceramics could promote cell adhesion, propagation and osteogenic differentiation performance. Thus, our research results suggest that the highly bioactive Y‐TZP ceramics could be a potential candidate for dental implant material.
N‐α‐Acetyltransferase 10 inhibits invasion and metastasis of oral squamous cell carcinoma via regulating Pirh2‐p53 signalling pathway
Authors: Wang Fazhan , Zheng Jun , Yang Jie , Luo Ting , Xu Jiang , Yang Yongyong , Gu Yongqing , Zeng Yan 
Published: April 2022

AbstractN‐α‐Acetyltransferase 10 (NAA10) was reported to be involved in tumour invasion and metastasis in several of tumours. However, the role and mechanism of NAA10‐mediated invasion and metastasis in oral squamous cell carcinoma (OSCC) remains undetermined. Herein, our study showed that NAA10 inhibits cell migration and invasion in vitro and attenuates the xenograft tumorigenesis in nude mice. Mechanistically, we demonstrated that there is a physical interaction between NAA10 and RelA/p65 in OSCC cells, thereby preventing RelA/p65‐mediated transcriptional activation of Pirh2. Consequently, inhibition of Pirh2 increased p53 level and suppressed the expression of p53 downstream targets, matrix metalloprotein‐2 (MMP‐2) and MMP‐9. Therefore, NAA10 may function as a tumour metastasis suppressor in the progression of OSCC by targeting Pirh2‐p53 axis and might be a prognostic marker as well as a therapeutic target for OSCC.
Prevalence and characterization of treatment‐refractory psoriasis and super‐responders to biologic treatment: a nationwide study
Authors: Loft N. , Egeberg A. , Rasmussen M.K. , Bryld L.E. , Nissen C.V. , Dam T.N. , Ajgeiy K.K. , Iversen L. , Skov L. 
Published: April 2022

AbstractIntroductionTreatment with biologics often leads to clearance of psoriasis. However, some patients do repeatedly fail to respond and/or lose an achieved response (treatment refractory) to the biologic, whereas other patients achieve excellent response to one biologic and remain clear of psoriasis for several years (super‐responders).ObjectiveTo identify and characterize patients with treatment refractory psoriasis and patients who are super‐responders to biologic treatment.Material and methodsPatients registered in DERMBIO between January 2007 and November 2019 were included. Patients were categorized as being treatment refractory if they had had treatment failure to ≥3 biologics targeting ≥2 different pathways. Super‐responders were patients treated with their first biologic for minimum 5 years without an absolute psoriasis area and severity index (PASI) > 3 between 6 months and 5 years of treatment. All remaining patients from DERMBIO served as comparators.ResultsIn total, 3280 patients were included with a mean age of 45.0 years. 1221 (37%) of the patients were females. Of the included patients, 214 (6.5%) were categorized as treatment refractory and 207 (6.3%) were categorized as super‐responders. Treatment refractory patients had higher mean body weight (100.6 kg vs. 90.6 kg, P < 0.0001) and higher mean BMI (32.2 vs. 29.4, P < 0.0001) compared with the rest of patients in DERMBIO. Super‐responders had higher socioeconomic status and fewer comorbidities compared with the comparator group (P < 0.0001).ConclusionA small proportion of patients with psoriasis treated with biologics are either super‐responders or treatment refractory. Treatment refractory patients have higher body weight, whereas super‐responders have fewer comorbidities and higher socioeconomic status.
Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
Authors: Assan F. , Husson B. , Hegazy S. , Seneschal J. , Aubin F. , Mahé E. , Jullien D. , Sbidian E. , D'Incan M. , Conrad C. , Brenaut E. , Girard C. , Richard M.A. , Bachelez H. , Viguier M. ,   “Groupe de Recherche sur le Psoriasis” de la Société Française de Dermatologie
Published: April 2022

AbstractBackgroundAcral pustular disease within the pustular psoriasis/psoriasis‐like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiologic characteristics of ACH and PPP.ObjectivesWe aimed to perform a comparative description of the epidemiological and clinical characteristics of PPP and ACH in a multicentre retrospective cohort.MethodsIn this multicentre national retrospective cohort study, we compared the epidemiological characteristics, comorbidities and psoriasis characteristics of patients with PPP and ACH.ResultsA total of 234 patients were included: 203 (87%) with PPP, 18 (8%) with ACH and 13 (6%) with both, according to 2017 ERASPEN criteria. As compared with ACH, PPP was associated with female sex, smoking activity and higher median BMI (P = 0.01, P = 0.02 and P = 0.05 respectively). A family background of psoriasis was more frequent in PPP than ACH. Age of onset of palmoplantar disease was similar between PPP and ACH patients, median age 44 and 48 years respectively. Peripheral joint inflammatory involvement was the only rheumatic disease associated with ACH. The association with another psoriasis type was similar in PPP and ACH (57.6% and 61.1% respectively).ConclusionOur study confirms in a large PPP cohort the predominance of females and a high prevalence of smoking and elevated body mass index but also shows an association of these features in PPP as compared with ACH. In addition, it highlights peripheral arthritis as the only arthritis endotype associated with ACH. Increased knowledge of the immunogenetic backgrounds underlying these two entities is warranted to better stratify pustular psoriasis or psoriasis‐like entities for precision medicine.