bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Dialysis “Becomes Life”: Pediatric Caregivers' Lived Experiences Obtained From Patient-Reported Outcomes Measures
Authors: Levy Erez Daniella , Meyers Melissa R. , Raman Swathi , Thomas Melissa , Furth Susan , Forrest Christopher B. , Denburg Michelle 
Published: May 2022

IntroductionQualitative research reveals significant caregiver impact resulting from managing children requiring chronic dialysis but offers few quantitative measures of their lived experiences.Materials and MethodsThis cross-sectional study included 25 caregivers of children on chronic peritoneal dialysis (PD) and hemodialysis (HD) enrolled from 2018 to 2019 at a large pediatric dialysis program in the U.S.Patient Reported Outcomes Measures Information System (PROMIS) measures and free text commentary were collected and analyzed to evaluate the self-reported impact and wellbeing of these caregivers.ResultsAmong all dialysis modalities, caregivers' positive affect (43.4 ± 10) and general life satisfaction (45.1 ± 11.5) were significantly lower than the general adult population. Compared with HD caregivers, PD caregivers demonstrated significantly more fatigue and sleep disturbance and less positive affect and life satisfaction. Amongst HD caregivers, sleep disturbance, positive affect, and meaning/purpose differed significantly from the general population. Analyses of text commentary revealed that caregivers also expressed the feelings of loss, importance of knowing the impact of dialysis prior to initiation, need for a support group, and value of home nursing.ConclusionsCaregivers of children on chronic dialysis had significantly poorer self-rated health and wellbeing compared with the general adult population. This may be due in part to their feelings of social isolation. Our findings highlight opportunities to improve caregivers' lived experiences.
Effectiveness and Safety of Atazanavir Use for the Treatment of Children and Adolescents Living With HIV: A Systematic Review
Authors: Saint-Lary Laura , Dassi Tchoupa Revegue Marc Harris , Jesson Julie , Renaud Françoise , Penazzato Martina , Townsend Claire L. , O'Rourke John , Leroy Valériane ,   WHO HIV Hepatitis and STIs (HHS) Department
Published: May 2022

BackgroundAtazanavir/ritonavir is recommended as a preferred second-line antiretroviral regimen in children older than 3 months, alternatively to lopinavir/ritonavir. We performed a systematic review to assess safety and effectiveness of atazanavir use in children and adolescents.MethodsWe searched observational studies and clinical trials on Web of Science, Embase and Cochrane CENTRAL database between 2009/01/01 and 2020/10/01; as well as grey literature. We extracted safety (adverse events, grade 3 or 4 adverse events, treatment discontinuation) and effectiveness (CD4 cell counts and HIV viral load) outcomes. We estimated weighted summary pooled incidence with corresponding 95% confidence intervals.ResultsOut of the 1,085 records screened, we included five studies (one comparative cohort, three single phase 2-3 trial arms, one retrospective cohort) reporting 975 children and adolescents, of whom 56% (544) received atazanavir. Three studies reported all-cause treatment discontinuation rates, yielding a pooled incidence of 19% [15–22] at 12 months. The comparative cohort compared atazanavir to darunavir, with few grade 3–4 adverse events, except transient hyperbilirubinemia, occurring in half (92/188) of the atazanavir patients. No death occurred (two studies reporting). Four studies described increased CD4 cell counts and decreased HIV viral load at 6 or 12 months.ConclusionFew safety and effectiveness data were available for children and adolescents exposed to atazanavir. Transient grade 3–4 hyperbilirubinemia was the main adverse outcome reported. Immune and viral responses were descriptive. The use of atazanavir/ritonavir in children and adolescents needs further investigation, but remains a suitable option for a preferred second-line antiretroviral regimen.PROSPERO numberCRD42022309230
Fermented Rosa Roxburghii Tratt Juice Alleviates High-Fat Diet-Induced Hyperlipidemia in Rats by Modulating Gut Microbiota and Metabolites
Authors: Ji Jiacheng , Zhang Shuo , Yuan Minyan , Zhang Min , Tang Li , Wang Pengjiao , Liu Yujie , Xu Changqian , Luo Peng , Gao Xiuli 
Published: May 2022

Hyperlipidemia endangers human health and has become a significant public health problem. This study aimed to investigate the mechanism of the hypolipidemic effects of Fermented Rosa roxburghii Tratt juice (FRRT) on hyperlipidemic rats and a new hypolipidemic intervention strategy was disclosed. The study revealed 12 weeks FRRT treatment significantly decreased the body weight, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-c), while high-density lipoprotein cholesterol (HDL-c) increased. We integrated the 16S rDNA sequencing and metabolomic profiling to evaluate the changes in the gut microbiota and metabolites. Significant changes in microbial composition accompanied marked changes in 56 feces metabolites. The results showed that FRRT could decrease the ratio of Firmicutes to Bacteroidetes, while increase the abundance of some bacterial genera (Prevotella, Paraprevotellaceae_Prevotella, Ruminococcus, Oscillospira). Metabolomics analysis displayed that the metabolisms of bile acid, amino acid and lipid were significantly affected by FRRT. Correlation analysis suggest that the reductions in serum lipids by FRRT are associated with the gut microbial community and their associated metabolites (amino acid metabolites, bile acid metabolites, and lipid metabolites). This study confirmed FRRT could be used as a new dietary and therapeutic strategy to dyslipidemia by improving the gut microbiota dysbiosis, metabolomic disorders and regulating the dyslipidemia. Our study also extended the understanding of the relationship between gut microbiota, metabolites, and lipid-lowering functions.
Heat Stress Affects Jejunal Immunity of Yellow-Feathered Broilers and Is Potentially Mediated by the Microbiome
Authors: Liu Wen-Chao , Huang Meng-Yi , Balasubramanian Balamuralikrishnan , Jha Rajesh 
Published: May 2022

In the perspective of the global climate change leading to increasing temperature, heat stress (HS) has become a severe issue in broiler production, including the indigenous yellow-feathered broilers. The present study aimed to investigate the effects of HS on jejunal immune response, microbiota structure and their correlation in yellow-feathered broilers. A total of forty female broilers (56-days-old) were randomly and equally divided into normal treatment group (NT group, 21.3 ± 1.2°C, 24 h/day) and HS group (32.5 ± 1.4°C, 8 h/day) with five replicates of each for 4 weeks feeding trial. The results showed that HS exposure increased the contents of TNF-α, IL-1β, and IL-6 in jejunal mucosa (p &lt; 0.05). The HS exposure up-regulated the relative fold changes of NF-κB, TNF-α, IL-1β, and IL-6 (p &lt; 0.01) while down-regulated the relative fold change of IFN-γ in jejunal mucosa (p &lt; 0.05). Meanwhile, HS had no significant impacts on alpha diversity of jejunal microbiota such as Simpson, Chao1 richness estimator (Chao 1), abundance-based coverage estimators (ACE), and Shannon index (p &gt; 0.10). Broilers exposed to HS reduced the jejunal microbial species number at the class and order level (p &lt; 0.05). Moreover, HS decreased the relative abundance of Ruminococcus, Bdellovibrio, and Serratia at the genus level in jejunum (p &lt; 0.05). At the phylum level, four species of bacteria (Bacteroidetes, Cyanobacteria, Thermi, and TM7) were significantly associated with immune-related genes expression (p &lt; 0.05). At the genus level, ten species of bacteria were significantly correlated with the expression of immune-related genes (p &lt; 0.05), including Caulobacteraceae, Actinomyces, Ruminococcaceae, Thermus, Bdellovibrio, Clostridiales, Sediminibacterium, Bacteroides, Sphingomonadales and Ruminococcus. In particular, the microbial with significantly different abundances, Ruminococcus and Bdellovibrio, were negatively associated with pro-inflammatory cytokines expression (p &lt; 0.05). These findings demonstrated that HS exposure promoted the production of pro-inflammatory cytokines in yellow-feathered broilers’ jejunum. The detrimental effects of HS on jejunal immune response might be related to dysbiosis, especially the reduced levels of Ruminococcus and Bdellovibrio.
A Multicenter Cohort Study on the Adverse Effects Evaluation After Messenger RNA COVID-19 Vaccination Among Pregnant Healthcare Employees in Penang General Hospitals
Authors: Arulappen Ann Lisa , Danial Monica , Shanmugam Gaiyathri , Cheng Joo Thye , Dulasi Mairin , Chow Ting Soo 
Published: May 2022

IntroductionThe year 2020 saw the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which became a great threat to public health worldwide. The exponential spread of the disease with millions of lives lost worldwide saw the emergence of an accelerated vaccine development with emergency approval from well-known regulatory bodies such as the US Food and Drug Administration, followed by widespread vaccine deployment despite a paucity in safety profile data. This issue becomes even more pronounced when it involves expectant mothers considering the possible undesirable effect toward the unborn child.MethodThis was a retrospective cohort study which was conducted at six general hospitals in the state of Penang, Malaysia. All the pregnant employees who have consented to take the mRNA COVID-19 vaccine and participate in this study were monitored from the time of their first vaccination and up to 28 days after they delivered their babies.ResultsAll the participants had adequate maximum vertical pocket (MVP) and no obvious anomalies or detection of intrauterine growth restriction (IUGR) were detected during the second trimester. However, one subject was reported to have miscarried during the second trimester. The reported mean neonate birth weight was 3.0 kg with the mean Apgar score of 8.8 and 9.8 at 1 and 5 min, respectively. Approximately seven (5.8%) neonates were reported to be small for their gestational age. Another three (2.5%) neonates were reported to have anomalies.ConclusionAs a whole, the inference that can be made from this study is that mRNA COVID-19 vaccine appears to be safe in pregnant women regardless of the trimester as the findings did not show obvious safety warning signs.
Characteristics of Oral Mucosal Lesions and Their Association With Socioeconomic Status and Systemic Health: A Cross-Sectional Study of Consecutively Collected Oral Medicine Clinic Data in a Remote Rural Area of China
Authors: Yao Hui , Zhang Qiongyue , Song Qianqian , Liu Mingshan , Tang Guoyao 
Published: May 2022

ObjectivesEpidemiological data of oral mucosal lesions (OMLs) are required to develop practical oral care policies. However, limited data are available for rural areas in China. We aimed to estimate the spectrum and frequency of OMLs and to identify their associated socioeconomic status (SES) and systemic health in a remote rural area in Yunnan, China.MethodsWe screened patients for OMLs in an oral medicine clinic in rural Yunnan, China, from August 2020 to February 2021. OMLs were documented. SES, including the highest education level achieved and the previous month's household income, as well as the patient's systemic health, including a history of smoking, alcohol use, and chronic disease, were obtained from the Medical History/Health Questionnaire Form and patient medical records.ResultsA total of 146 patients were found to have OMLs. The most frequent OML was aphthous ulcer (n = 41, 28.1%), followed by burning mouth syndrome (BMS) (n = 16, 11.0%), viral ulcer (n = 14, 9.6%), and oral lichen planus (OLP) (n = 9, 6.2%). In these patients, the most common chronic diseases were sleep apnea (n = 35, 24.0%), hypertension (n = 23, 15.8%), bronchitis (n = 16, 11.0%), reflux (including gastroesophageal reflux disease) (n = 12, 8.2%), and arthritis (n = 11, 7.5%). On adjusted regression, the patients without chronic diseases had a lower risk of BMS than those with chronic diseases [odds ratio (OR), 0.2; 95% confidence interval (CI), 0.03–0.9]. Age was an independent protective factor for viral ulcers (OR, 1.0; 95% CI, 0.9–1.0). Patients with low-income levels had a lower risk of OLP than those with high-income levels (OR, 0.2; 95% CI, 0.05–0.9).ConclusionsOur oral medicine clinic data in remote Yunnan, China, showed the most frequent OML was aphthous ulcer, which was followed by BMS, viral ulcer, and OLP. Oral care policies should be prioritized among patients with aphthous ulcer. Preventive strategy of BMS should be targeted to people with chronic disease for health equalities. Therefore, an individualized strategy for interventions of OMLs might be optimal, based on the specific epidemiologic characteristics in rural settings.
Unmet Dental Needs Among Mid-to-Older Deaf and Hard of Hearing Women in the U.S.
Authors: Donald Andrew , Rao Sowmya R. , Jacobs Katja , MacDonald Nthabeleng , Kushalnagar Poorna 
Published: May 2022

IntroductionDespite the significant number of deaf and hard of hearing (DHH) people living in the U.S., oral health research on DHH people who use American Sign Language (ASL) is virtually nonexistent. This study aims to investigate dental needs among mid-to-older DHH women and identify social determinants of health that may place them at higher risk for unmet dental health needs as the primary outcome.MethodsThis cross-sectional study uses data drawn from Communication Health domain in the PROMIS-DHH Profile and oral health data from the National Health and Nutrition Examination Survey. Both measures were administered in ASL and English between November 2019 and March 2020. Univariate and bivariate analysis included only complete data, and multivariable logistic regression analyses were conducted on multiply imputed data.ResultsOut of 197 DHH women (41 to 71+ years old) who answered the dental visit question, 48 had unmet dental needs and 149 had met dental needs. Adjusting for sociodemographic variables, disparity in dental needs was observed across education [OR (95% CI): 0.45(0.15, 1.370)] and communication health [0.95 (0.90, 1.01)].DiscussionOur study is the first to describe DHH mid-to-older women's access to oral health care. DHH women who do not have a college degree may be impacted. Further research is needed to elucidate the particular risk factors, including cultural, to which DHH individuals from marginalized racial groups are susceptible to unmet oral health needs.ConclusionsEvidence shows that DHH ASL users who have less years of education or are single experience barriers in accessing dental care.
STYLISTIC FEATURES OF THE COMPOSER’S HANDWRITING OF THE TEACHER-ARTIST HRYHORII LEVCHENKO
Authors: Lobach O. , Komyshan Yu. , Yakovlev V. 
Published: May 2022

The article analyzes the musical heritage of Hryhorii Levchenko – a modern famous choral conductor, composer, teacher, scientist, folklorist, public figure, founder and artistic director of the folk choir «Kalyna» in Poltava V. H. Korolenko National Pedagogical University. The characteristic features of the arranging heritage and author’s works of the teacher-artist are determined (reliance of author’s songs on folk traditions, which are harmoniously combined with modern methods of thematics and symphony of musical thinking); the original genres of choral art on the basis of folklore (lyrical-dramatic poem, choral symphony, choral fantasy, choral triptych, Concerto for Ukrainian folk choir, orchestra of folk instruments and piano).
parkrun and the promotion of physical activity: insights for primary care clinicians from an online survey
Authors: Haake Steve , Quirk Helen , Bullas Alice 
Published: May 2022

BackgroundTo support efforts to increase social prescribing and reduce levels of physical inactivity, parkrun UK and the Royal College of General Practitioners together developed the parkrun practice initiative to link general practices to local parkruns (free, weekly, timed, physical activity events). General practice staff are encouraged to take part in parkrun events themselves and to encourage patients to participate.AimTo provide insights for primary care clinicians about parkrun participants (parkrunners), especially those with characteristics of patients who might be signposted to physical activity.Design and settingSecondary analysis of an online survey of parkrunners in the UK.MethodResponders were ranked into 13 categories using mean parkrun finish time, allowing the following definitions: front runners; median runners; slower runners; runners/walkers; and walkers. Measures included demographics, health conditions, motives for first participating, and perceived impact on health and wellbeing.ResultsThe survey included 45 662 parkrunners. More than 9% of all participants and 45% of walkers were found to have at least one long-term health condition, including arthritis, obesity, depression, hypertension, chronic pain, anxiety, type 2 diabetes, and asthma. Walkers were less likely to be motivated by fitness or competition, and were more likely to be motivated by physical health. Despite these differences, perceived improvements to wellbeing were broadly similar for all parkrunners, regardless of their finishing time.ConclusionParkrunners are a diverse population in terms of their physical health. Information provided by this study could be combined with other research on the barriers to participation and successful brief interventions to help address the key issues of primary care clinicians’ knowledge and confidence about social prescribing to increase patients’ physical activity levels.
Design and Basic Characteristics of a National Patient-Powered Registry in ADPKD
Authors: Hoover Elise , Perrone Ronald D. , Rusconi Chris , Benson Beverly , Dahl Neera K. , Gitomer Berenice , Manelli Amy , Mrug Michal , Park Meyeon , Seliger Stephen L. , Phadnis Milind A. , Thewarapperuma Nadeesha , Watnick Terry J. 
Published: May 2022

Key Points

As of October 2021, more than 1500 autosomal dominant polycystic kidney disease (ADPKD) patients have signed up to participate in the ADPKD Registry, which collects patient-reported data.The Registry is a valuable tool for dissemination of information about studies for which individuals may qualify—seven studies so far.By incorporating two validated outcome measures, the ADPKD-IS and ADPKD-PDS, the Registry holds unique data on a national scale.

Background
Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease worldwide. Over the past five years, the therapeutic pipeline for ADPKD has expanded, leading to a growing need for patient enrollment in clinical trials and improved understanding of patient-centered outcomes that can be used in trial design. To advance these goals, the Polycystic Kidney Disease Foundation (PKDF) established a national web-based ADPKD Registry.

Methods
The ADPKD Registry is hosted on a secure, HIPAA-compliant, online platform (IQVIA, oc-meridian.com/pkdcure). Participants are consented through the online system and complete a series of modules. The Core Questionnaire includes patient-reported diagnosis, latest creatinine values, and comorbidities. Additional modules include surveys of family history, diet, quality of life, extrarenal manifestations, and attitudes surrounding research participation.

Results
As of October 2021, 1563 ADPKD patients across the United States have registered and completed the Core Questionnaire. Participants have a median age of 44 years and are 72% women, 93% White, with 4% self-identifying as Hispanic/Latino and 2% as Black. All CKD stages are present, including post kidney transplant. To date, seven clinical studies have used the Registry as a recruitment tool. Additionally, quality-of-life burden scores revealed a correlation with disease stage as determined by kidney function.

Conclusions
The Registry described here is the only one of its kind and is a valuable longitudinal research tool encompassing all stages of ADPKD. The registry will allow investigators to pursue a range of research questions related to the management of ADPKD, including definition of health-related quality of life (HRQoL) outcomes and recruitment for a variety of observational and therapeutic clinical protocols.
Pengembangan Media Edukasi Game Tastarok Tingkat Dasar untuk Meningkatkan Perilaku Pencegahan Merokok Anak
Authors: Mujito Mujito , Abiddin Andi Hayyun , Ulum Mohamad Miftachul 
Published: May 2022

Latar Belakang: Promosi perilaku tidak merokok di sekolah dasar merupakan suatu bentuk upaya promosi perilaku sehat khusus pada pengamanan zat adiktif tembakau. Hal ini untuk mengantisipasi kecenderungan peningkatan usia mulai merokok pada anak usia sekolah.
Tujuan : Menghasilkan media edukasi yang mampu menstimulasi perilaku pencegahan merokok pada anak usia sekolah.
Metode: Research and Development, dengan subyek penelitian terdiri 15 kelompok responden uji coba dan 20 kelompok responden penelitian, dari anak usia sekolah. Obyek yang diteliti adalah kualitas dan efektifitas media edukasi. Pengambilan data dengan teknik wawancara, pemberian kuesioner dan check list, untuk mengukur aspek kelayakan materi, rekayasa grafika dan efektifitas media.
Hasil: Hasil validasi produk dinyatakan sangat layak untuk digunakan sebagai media promosi kesehatan dibuktikan melalui hasil uji paired t-test dengan p=0.000, yang berarti ada perbedaan yang signifikan antara rerata keyakinan dalam perilaku pencegahan merokok sebelum dan sesudah intervensi.
Kesimpulan: Media edukasi permainan tastarok tingkat dasar dapat meningkatkan perilaku pencegahan merokok pada anak, sehingga tenaga promosi kesehatan diharapkan mampu menggunakan media edukasi ini dalam promosi kesehatan di sekolah
Crystal growth and optical properties of Ce-doped (Y, Lu)AlO3 single crystal
Authors: Horiai Takahiko , Pejchal Jan , Paterek Juraj , Kucerkova Romana , Yokota Yuui , Yoshikawa Akira , Nikl Martin 
Published: May 2022

Abstract
(Ce0.002 Y0.998−x
Lu
x
)AlO3 (x = 0.000, 0.010, 0.100, 0.200) single crystals were grown and characterized to clarify the effects of Lu substitution in Ce:YAlO3 on its crystal structure, optical properties and thermal stability of Ce3+ luminescence. The lattice constants of (Ce0.002 Y0.798 Lu0.200)AlO3 were comparable to those of Ce:YAlO3, so the crystal structure was not significantly influenced by Lu substitution. Concerning the optical characterization, the absorption and emission spectra were almost the same regardless the amount of Lu substitution. This result is consistent with the assumption that the crystal field is not influenced by Lu substitution. The temperature dependences of the photoluminescence decay time showed that the quenching temperature (T
50%) tends to increase with the increasing Lu concentration. We conclude that the leading quenching mechanism is the thermally activated ionization which is suppressed by the Lu substitution in Ce:YAlO3.