bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Covid-19 on research output by gender across countries
Authors: Abramo Giovanni , D’Angelo Ciriaco Andrea , Mele Ida 
Published: January 2022

AbstractThe massive shock of the COVID-19 pandemic has already shown its negative effects on economies around the world, unprecedented in recent history. COVID-19 infections and containment measures caused a general slowdown in research and new knowledge production. Because of the link between R&D output and economic growth, it is to be expected then that a slowdown in research activities will slow in turn the global recovery from the pandemic. Many recent studies also claim an uneven impact on scientific production across gender. In this paper, we investigate the phenomenon across countries, analysing preprint depositions in main repositories. Differently from other works, that compare the number of preprint depositions before and after the pandemic outbreak, we analyse the depositions trends across geographical areas, and contrast after-pandemic outbreak depositions with expected ones. Differently from common belief and initial evidence, the decrease in research output is not more severe for women than for men.
National and organizational patterns of Nobel laureate careers in physiology/medicine, physics, and chemistry
Authors: Heinze Thomas , Fuchs Joel Emanuel 
Published: January 2022

AbstractThis paper examines the distribution of Nobel laureates in Physiology/Medicine, Physics, and Chemistry across countries and research organizations. We provide basic information about where future laureates received their education and/or conducted their research, then present heat maps depicting country and organizational specialization patterns. In addition, we identify theorganizational ultra-elitein science: universities and research institutes that show continuously above-average numbers of future laureates, typically in one career phase. Furthermore, we identify those universities and research institutes that have undergone considerable growth (or decline) in their capabilities for highly innovative research. Also, we compare country-specific profiles with those at the organizational level. Our findings are interpreted in the light of findings from comparative-historical studies.
Catalytic Production of Renewable Hydrogen for Use in Fuel Cells: A Review Study
Authors: Rossetti Ilenia , Tripodi Antonio 
Published: January 2022

AbstractHydrogen production from renewable sources is gaining increasing importance for application as fuel, in particular with high efficiency and low impact devices such as fuel cells. In addition, the possibility to produce more sustainable hydrogen for industrial application is also of interest for fundamental industrial processes, such as ammonia and methanol synthesis. Catalytic processes are used in most options for the production of hydrogen from renewable sources. Catalysts are directly involved in the main transformation, as in the case of reforming and of electro-/photo-catalytic water splitting, or in the upgrade and refining of the main reaction products, as in the case of tar reforming. In every case, for the main processes that reached a sufficiently mature development stage, attempts of process design, economic and environmental impact assessment are presented, on one hand to finalise the demonstration of the technology, on the other hand to highlight the challenges and bottlenecks. Selected examples are described, highlighting whenever possible the role of catalysis and the open issues, e.g. for the H2 production from reforming, aqueous phase reforming, biomass pyrolysis and gasification, photo- and electro-catalytic processes, enzymatic catalysis. The case history of hydrogen production from bioethanol for use in fuel cells is detailed from the point of view of process design and techno-economic validation. Examples of steady state or dynamic simulation of a centralised or distributed H2 production unit are presented to demonstrate the feasibility of this technology, that appears as one of the nearest to market. The economic feasibility seems demonstrated when producing hydrogen starting from diluted bioethanol.
Kidney failure, CKD progression and mortality after nephrectomy
Authors: Ellis Robert J. , Cameron Anne , Gobe Glenda C. , Diwan Vishal , Healy Helen G. , Lee Jeremy , Tan Ken-Soon , Venuthurupalli Sree , Zhang Jianzhen , Hoy Wendy E. ,   the NHMRC CKD.CRE, the CKD.QLD Collaborative
Published: January 2022

Abstract
Purpose
This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes.

Methods
A sample of 5983 patients from five specialist nephrology practices was ascertained from the Queensland CKD Registry. Rates of kidney failure/death were compared on primary aetiology of CKD using multivariable Cox proportional hazards models. CKD progression was compared using multivariable linear and logistic regression analyses.

Results
Of 235 patients with an acquired single kidney as their primary cause of CKD, 24 (10%) and 38 (17%) developed kidney failure or died at median [IQR] follow-up times of 12.9 [2.5–31.0] and 33.6 [18.0–57.9] months after recruitment. Among patients with an eGFR < 45 mL/min per 1.73m2 at recruitment, patients with diabetic nephropathy and PCKD had the highest rates (per 1000 person-years) of kidney failure (107.8, 95% CI 71.0–163.8; 75.5, 95% CI 65.6–87.1); whereas, patients with glomerulonephritis and an acquired single kidney had lower rates (52.9, 95% CI 38.8–72.1; 34.6, 95% CI 20.5–58.4, respectively). Among patients with an eGFR ≥ 45 mL/min per 1.73m2, those with diabetic nephropathy had the highest rates of kidney failure (16.6, 95% CI 92.5–117.3); whereas, those with glomerulonephritis, PCKD and acquired single kidney had a lower risk (11.3, 95% CI 7.1–17.9; 11.7, 95% CI 3.8–36.2; 10.7, 95% CI 4.0–28.4, respectively).

Conclusion
Patients who developed CKD after nephrectomy had similar rates of adverse events to most other causes of CKD, except for diabetic nephropathy which was consistently associated with worse outcomes. While CKD after nephrectomy is not the most aggressive cause of kidney disease, it is by no means benign, and is associated with a tangible risk of kidney failure and death, which is comparable to other major causes of CKD.
The Value of Strident Agnosticism: Dorothy Pawluch and the Endurance of Ontological Gerrymandering
Authors: Woolgar Steve 
Published: January 2022

AbstractThis paper reflects on the origins and subsequent reception of the paper “Ontological Gerrymandering: The anatomy of social problems explanations”, published in 1985. It describes the circumstances of my turning up at McGill University as a Visiting Professor in Sociology and meeting Dorothy, then a graduate student and the TA assigned to an undergraduate course on Social Problems which I was asked to teach. The paper reflects on the twin benefits: of an interloper, from Europe and from Science and Technology Studies (STS), entering the exotic and heady fray of North American social problems; and of Dorothy’s steady and resolute guidance in introducing me to a new field. The paper suggests some reasons for the endurance of the paper’s arguments, more than 35 years after its publication, drawing on some parallel developments in Social Problems and STS. It asks why has there been rather little mutual interaction between these disciplines, given their common concern with questions, among others, about values, effects and interventions in academic scholarship. The paper concludes that many more of us might have done well to pursue the path of strident agnosticism.
Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome
Authors: TeBay Clifford , Hill Adam P. , Windley Monique J. 
Published: January 2022

AbstractDrug-induced long QT syndrome (diLQTS) is the phenomenon by which the administration of drugs causes prolongation of cardiac repolarisation and leads to an increased risk of the ventricular tachycardia known as torsades de pointes (TdP). In most cases of diLQTS, the primary molecular target is the human ether-à-go-go-related gene protein (hERG) potassium channel, which carries the rapid delayed rectifier current (IKr) in the heart. However, the proarrhythmic risk associated with drugs that block hERG can be modified in patients by a range of environmental- and disease-related factors, such as febrile temperatures, alterations in pH, dyselectrolytaemias such as hypokalaemia and hypomagnesemia and coadministration with other drugs. In this review, we will discuss the clinical occurrence of drug-induced LQTS in the context of these modifying factors as well as the mechanisms by which they contribute to altered hERG potency and proarrhythmic risk.
Antioxidant-containing monoolein aqueous dispersions: a preliminary study
Authors: Sguizzato Maddalena , Drechsler Markus , Baldisserotto Anna , Cortesi Rita , Esposito Elisabetta 
Published: January 2022

AbstractThe present study describes a preliminary study on the use of monoolein aqueous dispersions (MADs) as delivery systems for antioxidant molecules, namely, ascorbyl palmitate (AP) and alpha-tocopherol (AT). MAD, produced by emulsifying monoolein (4.5% w/w) in water and poloxamer 407 (0.5% w/w) as emulsifier, was characterized in terms of size, morphology, and antioxidant activity by mean of PCS, cryo-TEM, and (2,2-diphenyl-1-picrylhydrazyl) assay. MAD-AP or MAD-AT gave rise to a bimodal size distribution with mean size around 200 nm. All the preparations stored at 25 °C showed quite stable size at least up to 90 days. Cryo-TEM images confirmed MAD size distribution and indicated different MAD morphologies as a function of the loaded antioxidant molecule. Indeed, in the case of MAD-AP, vesicles and cubosomes with the typical inner cubic structure were observed, while vesicles and hexosomes were shown for MAD-AT. The encapsulation efficiency of both antioxidants reached more than 90% with respect to the total amount of drug used for MAD preparation. Moreover, AP and AT antioxidant activity was retained after encapsulation, and in vitro Franz cell experiments showed that the MAD enabled to better control the drug release. These preliminary results suggest that MAD formulations could be further investigated as a potential delivery system for antioxidant supplementation in dietary or cosmetic fields.
Graphical abstract
Genome-wide identification and characterization of grapevine UFD1 genes during berry development and salt stress response
Authors: Wei Lingzhu , Cheng Jianhui , Xiang Jiang , Wu Jiang 
Published: January 2022

AbstractGrapevine (Vitis vinifera) is widely applicated in food industry, which shows high economical and nutritional values. However, growth of grapevine was usually affected by various environmental stresses, such as salt, drought and disease. Ubiquitin fusion degradation protein 1 (UFD1) is an essential ubiquitin-recognition protein facilitates regulation of stress response through ERAD pathway. Even though, a comprehensive investigation of UFD1 genes in the plant species is still lacking. Here we identified three VvUFD1 proteins from genome of grapevine, which were assigned into different subgroups. All VvUFD1 genes contain highly conserved motifs in structure. Several cis-elements that related to fruit development and stress response were found in the promoter regions of VvUFD1 genes, including bHLH, NCA, MYB, HD-ZIP, GATA and AP2. Expression analysis found VvUFD1 genes showed different expression patterns in different tissues. Most importantly, VvUFD1 genes were found to be involved in salt stress response during growth of grapevine. Transcriptomic analyses were investigated for further understanding the genes’ function. Expression of VvUFD1 were increased at late stage of berry ripening. In addition, expression of VvUFD1 were also regulated by elevated light treatment and pathogen Neofusicoccum parvum infection. Co-expression network analysis revealed several major transcription factors that co-expressed with VvUFD1 genes. These results provide a basis for investigating the function of UFD1 genes in plant species and expand understanding of the regulation of berry development and salt stress response in grapevine.
Auslandsdeutsche Mediendiskurse: sprachliche und interkulturelle Aspekte von Minderheitenzeitungen
Authors: Földes Csaba 
Published: January 2022

ZusammenfassungDer Aufsatz behandelt einen in der Medienlinguistik noch weitgehend unerforschten Zeitungstyp: die Presse deutsch(sprachig)er Minderheiten im Ausland. Im Sinne eines Werkstattberichts fasst der Beitrag das Untersuchungsdesign, die zentralen Inhaltsstrukturen bzw. -elemente sowie die bisherigen Beobachtungen und Ergebnisse eines aktuellen Forschungsprojekts mit Überblickscharakter zusammen und stellt sie zur Diskussion. Am Beispiel von drei Minderheitenzeitungen aus Russland, Kasachstan und Ungarn konnte die explorative Studie u. a. zu folgenden Befunden gelangen: (1) Aufgrund von Mehrsprachigkeit und Mehrschriftlichkeit bildet vor allem eine Bandbreite sprachkontaktinduzierter Phänomene das wichtigste Alleinstellungsmerkmal dieser Zeitungen. (2) Es liegen viele etwas eklektische und stilistisch-pragmatisch inkonsistente Texte vor. (3) Inhaltliche und kulturinduzierte Auffälligkeiten prägen das Gesamtbild des untersuchten medialen Mikrokosmos. (4) Die Kompetenzbesonderheiten der mehrsprachigen Textproduzenten färben auf die Textgestaltung ab.
SUMO E3 ligase SIZ1 negatively regulates arsenite resistance via depressing GSH biosynthesis in Arabidopsis
Authors: Hong Yechun , Chen Yunjuan , Shi Huazhong , Kong Xiangfeng , Yao Juanjuan , Lei Mingguang , Zhu Jian-Kang , Wang Zhen 
Published: January 2022

AbstractArsenic is a metalloid toxic to plants, animals and human beings. Small ubiquitin-like modifier (SUMO) conjugation is involved in many biological processes in plants. However, the role of SUMOylation in regulating plant arsenic response is still unclear. In this study, we found that dysfunction of SUMO E3 ligase SIZ1 improves arsenite resistance in Arabidopsis. Overexpression of the dominant-negative SUMO E2 variant resembled the arsenite-resistant phenotype of siz1 mutant, indicating that SUMOylation plays a negative role in plant arsenite detoxification. The siz1 mutant accumulated more glutathione (GSH) than the wild type under arsenite stress, and the arsenite-resistant phenotype of siz1 was depressed by inhibiting GSH biosynthesis. The transcript levels of the genes in the GSH biosynthetic pathway were increased in the siz1 mutant comparing with the wild type in response to arsenite treatment. Taken together, our findings revealed a novel function of SIZ1 in modulating plant arsenite response through regulating the GSH-dependent detoxification.
Can Arbitrary Beliefs be Rational?
Authors: Skipper Mattias 
Published: January 2022

AbstractWhen a belief has been influenced, in part or whole, by factors that, by the believer's own lights, do not bear on the truth of the believed proposition, we can say that the belief has been, in a sense,arbitrarily formed. Can such beliefs ever be rational? It might seem obvious that they can't. After all, belief, supposedly, “aims at the truth.” But many epistemologists have come to think that certain kinds of arbitrary beliefs can, indeed, be rational. In this paper, I want to do two things. First, I want to show that the claim that arbitrary beliefs can be rational is inconsistent with the conjunction of two other attractive claims: one saying that rationality requires a certain kind ofepistemic immodesty, and one saying that rationality forbids certain kinds ofself-ascriptions of epistemic luck. Second, I want to evaluate different ways one might respond to this inconsistent triad. I won't defend any response in particular, but I'll draw out some notable costs and benefits of each response, which may help shed light on the question of whether arbitrary beliefs can be rational.
Can We Talk? The Application of the Public Law Democratic Dialogue Model to the Interactions between Domestic Legislatures and the European Courts
Authors: Gillis Matilda 
Published: January 2022

AbstractThe democratic dialogue model is a domestic constitutional model of rights protection, which is used to explain and evaluate the relationship between domestic courts and legislatures. It is characterised by there being some capacity on the part of the legislature to respond to a court decision and it claims, among other things, to produce a ‘better protection of human rights’. This paper examines whether the democratic dialogue model can be, and should be, applied to the relationship between state legislatures and, respectively, the European Court of Human Rights and the Court of Justice of the European Union (the European Courts). The paper first demonstrates that this proposed application of the model differs from other accounts of dialogue hitherto applied at the transnational level. It examines how exactly the model can be applied to the relationship between national legislatures and the European Courts and it demonstrates that the model provides an explanatory framework for the interactions between the institutions. It argues that the normative claims of the domestic dialogue model are achieved when the model is applied in the proposed way, but it acknowledges that the achievement of those normative claims might not always be desirable at the transnational level.
First evidence for Neoproterozoic rocks offshore South-East Greenland
Authors: Guarnieri Pierpaolo , Storey Michael , Thomsen Tonny B. , Heredia Benjamin Dominguez , Malkki Sebastian Næsby 
Published: January 2022

AbstractMeta-sedimentary rocks recovered beneath Palaeogene basalts near the base of Ocean Drilling Program (ODP) Leg 152-917A offshore South-East Greenland were thought to be of Late Cretaceous age. This interpretation, however, has several inconsistencies as it requires a tectono-metamorphic event during the Cretaceous not recognized in the North Atlantic region, and the presence of a wide Mesozoic sedimentary basin that extended from SE-Greenland to the Rockall Plateau, for which there is currently no evidence. Here, we report a Neoproterozoic U/Pb apatite age of 905 ± 21 Ma and a younger40Ar/39Ar isochron whole-rock age of 820 ± 40 Ma for an altered tuff layer that occurs in the upper part of the meta-volcaniclastic sequence recovered from hole 917A. The40Ar/39Ar step-heating ages on biotite and whole-rock mini-cores from deeper in hole 917A yielded Palaeoproterozic dates that cluster around 1950 to 1850 Ma, pointing toward a Palaeoproterozoic source. The U/Pb apatite date is interpreted as the eruption age of the tuff layer, whereas the younger whole-rock40Ar/39Ar age is consistent with low-temperature greenschist alteration of volcanic glass and secondary mineral growth during sedimentary burial in an extensional regime. Thec.905 Ma age for the tuff provides the first evidence for Neoproterozoic rocks offshore South-East Greenland and suggests a correlation between this sequence and the Torridon Group in the Hebridean Foreland of the Scottish Caledonides. The calc-alkaline nature of the volcaniclastic rocks and the age of the tuff layer point toward a source area with arc-magmatism related to the Renlandian event of the Valhalla Orogeny.
The heritability of Nematodirus battus fecal egg counts
Authors: Nikbin Saeid , Almasi Fazel , Alenizi Dalal , Jenvey Caitlin , Sloan Sarah , Preston Sarah , Piedrafita David , Jonsson Nicholas , Stear Michael 
Published: January 2022

AbstractAlthough Nematodirus battus is a serious threat to the health and survival of young lambs, there are few options to control this parasite. Bayesian Monte Carlo Markov Chain modelling with a zero-inflated Poisson distribution was used to estimate the heritability of egg counts in both June and July for each of five consecutive cohorts of 200 Scottish Blackface lambs. In one of the 10 analyses, the results failed the diagnostic tests. In seven of the analyses, there was no convincing evidence that the variation in egg counts was heritable. In the 2 years of high infection, the heritability was approximately 0.4 in June but the estimates lacked precision and the 95% highest posterior density credible intervals ranged from just above zero to 0.7. Selective breeding for resistance to N. battus will be difficult because genetically resistant or susceptible lambs cannot be consistently identified by phenotypic markers.
Three new species of Helicometroides Yamaguti, 1934 from Japan and Australia, with new molecular evidence of a widespread species
Authors: Wee Nicholas Q-X. , Cribb Thomas H. , Shirakashi Sho , Cutmore Scott C. 
Published: January 2022

Abstract
We report specimens of monorchiids infecting Haemulidae from the waters off Japan and Australia; these specimens represent five species of Helicometroides Yamaguti, 1934, three of which are unambiguously new. Helicometroides murakamii n. sp. infects Diagramma pictum pictum from off Minabe, Japan; Helicometroides gabrieli n. sp. infects Plectorhinchus chrysotaenia from off Lizard Island, Australia; and Helicometroides wardae n. sp. infects Plectorhinchus flavomaculatus and Plectorhinchus multivittatus from off Heron Island, Australia. Helicometroides murakamii n. sp. and H. gabrieli n. sp. conform to the most recent diagnosis of Helicometroides in lacking a terminal organ, but H. wardae n. sp. possesses a terminal organ with distinct, robust spines; despite this morphological distinction, the three form a strongly-supported clade in phylogenetic analyses. We also report specimens morphologically consistent with Helicometroides longicollis Yamaguti, 1934, from D. pictum pictum from off Minabe, Japan, and Diagramma pictum labiosum on the Great Barrier Reef, Australia. Genetic analyses of ITS2 rDNA, 28S rDNA and cox1 mtDNA sequence data for the Japanese specimens reveal the presence of two distinct genotypes. Specimens of the two genotypes were discovered in mixed infections and are morphologically indistinguishable; neither genotype can be associated definitively with H. longicollis as originally described. We thus identify them as H. longicollis lineage 1 and 2, pending study of further fresh material. Genetic analyses of specimens from the Great Barrier Reef are consistent with the presence of only H. longicollis lineage 1. This species thus has a range that incorporates at least Australia and Japan, localities separated by over 7000 km.
Ecological specificity explains infection parameters of anuran parasites at different scales
Authors: Euclydes Lorena , De La Torre Gabriel M. , Dudczak Amanda Caroline , Melo Francisco Tiago de Vasconcelos , Campião Karla Magalhães 
Published: January 2022

AbstractUnderstanding the determinants of parasite infection in different hosts is one of the main goals of disease ecology. Evaluating the relationship between parasite–host specificity and infection parameters within host communities and populations may contribute to this understanding. Here we propose two measures of specificity that encompasses phylogenetic and ecological relatedness among hosts and investigated how such metrics explain parasite infection prevalence and mean infection intensity (MII). We analysed the parasites associated with an anuran community in an area of Atlantic Forest and used the number of infected hosts and the net relatedness index to calculate the phylogenetic and ecological specificities of the parasites. These specificity measures were related to infection metrics (prevalence and MII) with generalized linear mixed models at community (all hosts) and population (infected host species) scales. Parasite prevalence was correlated with the number of infected hosts and, when considering only multi-host parasites, was positively related to parasite ecological specificity at community and population scales. Thus, parasite species have similar prevalences in ecologically closer hosts. No relationship was found for parasite MII. Incorporating ecological characteristics of hosts in parasite specificity analyses improves the detection of patterns of specificity across scales.