bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venation‐Mimicking, Ultrastretchable, Room‐Temperature‐Attachable Metal Tapes for Integrated Electronic Skins
Authors: Feng Bin , Sun Tianming , Wang Wengan , Xiao Yu , Huo Jinpeng , Deng Zhongyang , Bian Gongbo , Wu Yuxi , Zou Guisheng , Wang Wenxian , Ren Tianling , Liu Lei 
Published: December 2022

AbstractFuture electronic skin systems require stretchable conductors and low‐temperature integration of external components, which remains challenging for traditional metal films. Herein, a bioinspired design concept is reported to endow metal films with 200% stretchability as well as room‐temperature integration capability with diverse components. It is revealed that by controllable implantation of defects, distinctive venation‐mimicking cracking modes can be induced in strained metal films, leading to profound stretchability regulation. An intriguing exponential‐to‐linear transition of the film electromechanical performance is observed, which is elucidated by a unified model covering the essence of all modes. Combined with room‐temperature integration capability, an integrated electronic skin is constructed with metal films serving as stretchable electrodes, diverse sensors, and “tapes” to attach subcomponents, showing prospects in helping disabled people. This one‐step, defect implantation strategy is applicable to common metals without special substrate treatments, which enables fascinating ultrastretchable metal film conductors with low‐temperature integration capability to spark more sophisticated flexible electronic systems.
Dual‐Rotor Luminescence Based on Supramolecular Secondary Reassembly
Authors: Xu Wen‐Wen , Qin Yue‐Xiu , Niu Jie , Xu Wenshi , Chen Yong , Zhang Heng‐Yi , Liu Yu 
Published: December 2022

AbstractHerein, synergistically confining anthracene‐phenylpyridium derivatives (1’ and 1) as dual‐rotor luminogens through macrocyclic cucurbit[8]uril (CB[8]) and hyaluronic acid (HA) mediated supramolecular secondary reassembly is reported to give bright fluorescence emission. The non‐emissive dual‐rotor molecule 1 first assembles with CB[8] to form non‐emissive supramolecular nanotubes, which are further reconstructed to be nanoparticles with a diameter of 83 nm by HA induced secondary reassembly through electrostatic interaction. Intriguingly, the secondary reassembly not only transforms the topological morphology, but also acts as a switch to activate the robust fluorescence of dual‐rotor molecule, accompanying emission at 600 nm with large Stokes shift (150 nm). This activation is mainly attributed to sufficient suppression of intramolecular rotation and promotion of intramolecular charge transfer of dual‐rotor molecule after reassembly. Benefiting from multiple components synergistic stimuli‐responsiveness and the targeted ability of HA to tumor cells, the secondary reassembly constructed dual‐rotor luminescence system is successfully applied in triplet encryption information security and targeted cancer cell imaging.
Giant Polyoxoniobate‐Based Inorganic Molecular Tweezers: Metal Recognitions, Ion‐Exchange Interactions and Mechanism Studies
Authors: Wu Ping‐Xin , Guo Zheng‐Wei , Lai Rong‐Da , Li Xin‐Xiong , Sun Cai , Zheng Shou‐Tian 
Published: December 2022

AbstractThis work reports the interesting and unique cation‐exchange behaviors of the first indium‐bridged purely inorganic 3D framework based on high‐nuclearity polyoxoniobates as building units. Each nanoscale polyoxoniobate features a fascinating near‐icosahedral core–shell structure with six pairs of unique inorganic “molecular tweezers” that have changeable openings for binding different metal cations via ion‐exchanges and exhibit unusual selective metal‐uptake behaviors. Further, the material has high chemical stability so that can undergo single‐crystal‐to‐single‐crystal metal‐exchange processes to produce a dozen new crystals with high crystallinity. Based on these crystals and time‐dependent metal‐exchange experiments, we can visually reveal the detailed metal‐exchange interactions and mechanisms of the material at the atomic precision level. This work demonstrates a rare systematic and atomic‐level study on the ion‐exchange properties of nanoclusters, which is of significance for the exploration of cluster‐based ion‐exchange materials that are still to be developed.
A report on learning gains and student confidence after incorporating an enzyme purification and characterization course‐based undergraduate experience
Authors: Jones Eric , Glanz Hunter , Wilkinson Steven , Fogle Emily 
Published: December 2022

AbstractCourse‐based undergraduate research experiences (CUREs) can provide undergraduate students access to research opportunities when student and faculty resources are limited. In addition to expanding research opportunities, CUREs may also be explored as a pedagogical tool for improving student learning of course content and laboratory skills, as well as improving meta‐cognitive features such as confidence. We examined how a 6‐week CURE in an upper‐level undergraduate biochemistry lab affected student gains in content knowledge and confidence in scientific abilities, compared to a non‐CURE section of the same course. We find that gains in content knowledge were similar between CURE and non‐CURE sections, indicating the CURE does not negatively impact student learning. The CURE was associated with a statistically significant gain in student confidence, compared to non‐CURE group. These results show that even a relatively short CURE can be effective in improving student confidence at scientific research skills, in addition to expanding access to research.
Myxococcus xanthus as Host for the Production of Benzoxazoles
Authors: Winand Lea , Lernoud Lucia , Meyners Saskia Anna , Kuhr Katharina , Hiller Wolf , Nett Markus 
Published: December 2022

AbstractBenzoxazoles are important structural motifs in pharmaceutical drugs. Here, we present the heterologous production of 3‐hydroxyanthranilate‐derived benzoxazoles in the host bacterium Myxococcus xanthus following the expression of two genes from the nataxazole biosynthetic gene cluster of Streptomyces sp. Tü 6176. The M. xanthus expression strain achieved a benzoxazole titer of 114.6±7.4 mg L−1 upon precursor supplementation, which is superior to other bacterial production systems. Crosstalk between the heterologously expressed benzoxazole pathway and the endogenous myxochelin pathway led to the combinatorial biosynthesis of benzoxazoles featuring a 2,3‐dihydroxybenzoic acid (2,3‐DHBA) building block. Subsequent in vitro studies confirmed that this crosstalk is not only due to the availability of 2,3‐DHBA in M. xanthus, rather, it is promoted by the adenylating enzyme MxcE from the myxochelin pathway, which contributes to the activation of aryl carboxylic acids and delivers them to benzoxazole biosynthesis.
Bulk preparation of free‐standing single‐iron‐atom catalysts directly as the air electrodes for high‐performance zinc‐air batteries
Authors: Zhang Hong‐Bo , Meng Yu , Zhong Hong , Zhang Lili , Ding Shichao , Fang Lingzhe , Li Tao , Mei Yi , Hou Peng‐Xiang , Liu Chang , Beckman Scott P. , Lin Yuehe , Cheng Hui‐Ming , Li Jin‐Cheng 
Published: December 2022

AbstractThe keen interest in fuel cells and metal‐air batteries stimulates a great deal of research on the development of a cost‐efficient and high‐performance catalyst as an alternative to traditional Pt to boost the sluggish oxygen reduction reaction (ORR) at the cathode. Herein, we report a facile and scalable strategy for the large‐scale preparation of a free‐standing and flexible porous atomically dispersed Fe–N‐doped carbon microtube (FeSAC/PCMT) sponge. Benefiting from its unique structure that greatly facilitates the catalytic kinetics, mass transport, and electron transfer, our FeSAC/PCMT electrode exhibits excellent performance with an ORR potential of 0.942 V at −3 mA cm−2. When the FeSAC/PCMT sponge was directly used as an oxygen electrode for liquid‐state and flexible solid‐state zinc‐air batteries, high peak power densities of 183.1 and 58.0 mW cm−2 were respectively achieved, better than its powdery counterpart and commercial Pt/C catalyst. Experimental and theoretical investigation results demonstrate that such ultrahigh ORR performance can be attributed to atomically dispersed Fe–N5 species in FeSAC/PCMT. This study presents a cost‐effective and scalable strategy for the fabrication of highly efficient and flexible oxygen electrodes, provides a significant new insight into the catalytic mechanisms, and helps to realize significant advances in energy devices.
Enhanced Photocatalytic Activity of Hyper‐Cross‐Linked Polymers Toward Amines Oxidation Coupled with H2O2 Generation through Extending Monomer's Conjugation Degree
Authors: Nie Xinhao , Zhao Ying , Gao Wei , Liu Weihua , Cheng Xiang , Gao Yongjun , Shang Ningzhao , Gao Shutao , Wang Chun 
Published: December 2022

AbstractVisible‐light‐driven amines oxidation coupled with hydrogen peroxide (H2O2) generation is a promising way to convert solar energy to chemical energy. Herein, a series of hyper‐cross‐linked polymers (HCPs) photocatalysts with different arenes monomers, including benzene (BE), diphenyl (DP), p‐terphenyl (TP), or p‐quaterphenyl (QP), were synthesized by simple Friedel–Crafts alkylation reaction. Owing to the maximum monomer's conjunction degree and excellent oxygen (O2) adsorption capacity, QP‐HCPs exhibited highest photocatalytic activity for benzylamine oxidation coupled with H2O2 generation under the irradiation of 455 nm Blue LED lamp. More than 99 % of benzylamine could be converted to N‐benzylidenebenzylamine within 60 min. In addition, nearly stoichiometric H2O2 was synchronously obtained with a high production rate of 9.3 mmol gcat−1 h−1. Our work not only demonstrated that the photocatalytic activity of HCPs photocatalysts significantly depends on monomer's conjunction degree, but also provided a new strategy for converting solar energy to chemical energy.
Robuste Problemlöser
Authors: Homburg Claudia 
Published: December 2022

AbstractIn Minen geht man nicht gerade zimperlich mit Messgeräten um. Die Messorte liegen oft weit unter der Erdoberfläche ‐ zudem führen Staub, Geröll und Lärm jede Füllstandmessung an ihre Grenzen. Dennoch behaupten sich Radarmessgeräte von Vega in diesem schwierigen Umfeld, wie zwei Beispiele aus Südafrika zeigen.
Novel EGFR‐MAPK kinase and ABC transporter inhibitors for HepG2 resistant to Erlotinib
Authors: Ostlund Trevor , SutraDhar Kakan , Elgazwi Sara M. , Mahnashi Mater , Kyeremateng Jennifer , Iram Surtaj , Halaweish Fathi 
Published: December 2022

AbstractHepatocellular carcinoma (HCC) is the third‐leading cause of cancer death in the world, with outlook for most patients having a 5‐year survivability of less than 5%. In a previous study from our laboratory, novel estrone inspired analogs act as epidermal growth factor receptor (EGFR) inhibitors in HepG2 cells. This study focuses on the effect of these analogs on an HCC cell line resistance to Erlotinib. Lead compounds MMA132 and MMA102 showed 13 and 20 µM IC50 values, respectively against HepG2‐R resistant to Erlotinib. These compounds showed cell cycle arrest of the G2 phase up to 54%, and inhibited cell migration of HepG2‐R cells up to 48 h. Western blot analysis revealed that MMA132 reduced total EGFR content after 48 h, while MMA102 inhibited MEK kinase by 84% after 48 h. Western blot analysis also revealed that multidrug resistance protein 2 (MRP2) is overexpressed in HepG2‐R, suggesting that ABC transporters play a likely cause in drug resistance. MMA102 showed significant inhibition of both P‐glycoprotein (83%) and ABCG2 (53%), two additional ABC transporters. Additionally, MMA102 and MMA132 were used in a combination therapy with MK571(MRP1/2 inhibitor) and produced IC50 values of 18 and 10 µM, respectively, better than either MMA102/132 or MK571 alone. To validate our findings, we conducted molecular dynamic simulations with MMA102 and MMA132 in MEK, P‐glycoprotein, MRP1, and MRP2. Results coincided with biological findings in which MMA102 orientation is favored in both MEK and P‐glycoprotein pockets, whereas MMA132 likely binds with MRP2, as likely suggested by the combinatorial study.
Environmental niche overlap in sibling planktonic species Calanus finmarchicus and C. glacialis in Arctic fjords
Authors: Weydmann‐Zwolicka Agata , Cottier Finlo , Berge Jørgen , Majaneva Sanna , Kukliński Piotr , Zwolicki Adrian 
Published: December 2022

AbstractKnowledge of environmental preferences of the key planktonic species, such as Calanus copepods in the Arctic, is crucial to understand ecosystem function and its future under climate change. Here, we assessed the environmental conditions influencing the development stages of Atlantic Calanus finmarchicus and Arctic Calanus glacialis, and we quantified the extent to which their niches overlap by incorporating multiple environmental data. We based our analysis on a 3‐year seasonal collection of zooplankton by sediment traps, located on moorings in two contrasting Svalbard fjords: the Arctic Rijpfjorden and the Atlantic‐influenced Kongsfjorden. Despite large differences in water temperature between the fjords, local realized ecological niches of the sibling Calanus species overlapped almost perfectly. The exception was the earliest copepodites of C. glacialis in Rijpfjorden, which probably utilized the local ice algal bloom in spring. However, during periods with no sea ice, like in Kongsfjorden, the siblings of both Calanus species showed high synchronization in the population structure. Interestingly, differences in temperature preferences of C. finmarchicus and C. glacialis were much higher between the studied fjords than between the species. Our analysis confirmed the high plasticity of Calanus copepods and their abilities to adapt to highly variable environmental settings, not only on an interannual basis but also in a climate warming context, indicating some resilience in the Calanus community.
Real‐life research projects improve student engagement and provide reliable data for academics
Authors: Marley Sarah A. , Siani Alessandro , Sims Stuart 
Published: December 2022

AbstractStudent engagement can have a positive influence on student success. Many methods exist for fostering engagement but tend to be generic and require tailoring to specific contexts, subjects, and students. In the case of undergraduate science students, practical classes are a popular tool for increasing engagement. However, despite strong potential for improvement via links with “real life” research projects (RLRPs), few academic staff incorporate research participation with teaching activities. This is potentially due to poor time availability and low opinions of students' ability to collect reliable data. This study aims to examine whether involvement with RLRPs can generate reliable scientific data and also act as a motivational tool for engaging tertiary science students. A preexisting core activity for first‐year biology and marine biology students was modified to include a short RLRP component. Student‐based data collection and a questionnaire about experiences were used to examine the reliability of student‐collected data and student perceptions of RLRPs. Results indicated that error rate in student‐collected data was minimal. Irrespective of participating in a “normal” practical class or a class with a RLRP component, students collected equally accurate data. However, when the topic aligned specifically with their degree subject, student accuracy was higher. All students surveyed reported high motivation with the idea of RLRP participation, placing high importance on this from an educational and employability perspective. Yet, students were not confident about participating in RLRPs until they had engaged with one, suggesting that introducing such projects into taught sessions early‐on may encourage students to seek further opportunities in the future. In conclusion, incorporating RLRPs into the curriculum of undergraduate science courses has considerable potential benefits for both students and academic staff.
The role of genomic signatures of directional selection and demographic history in the population structure of a marine teleost with high gene flow
Authors: Weist Peggy , Jentoft Sissel , Tørresen Ole K. , Schade Franziska M. , Pampoulie Christophe , Krumme Uwe , Hanel Reinhold 
Published: December 2022

AbstractRecent studies have uncovered patterns of genomic divergence in marine teleosts where panmixia due to high gene flow has been the general paradigm. These signatures of divergent selection are often impacted by structural variants, acting as “supergenes” facilitating local adaptation. The highly dispersing European plaice (Pleuronectes platessa)—in which putative structural variants (i.e., inversions) have been identified—has successfully colonized the brackish water ecosystem of the Baltic Sea. Thus, the species represents an ideal opportunity to investigate how the interplay of gene flow, structural variants, natural selection, past demographic history, and gene flow impacts on population (sub)structuring in marine systems. Here, we report on the generation of an annotated draft plaice genome assembly in combination with population sequencing data—following the salinity gradient from the Baltic Sea into the North Sea together with samples from Icelandic waters—to illuminate genome‐wide patterns of divergence. Neutral markers pointed at large‐scale panmixia across the European continental shelf associated with high gene flow and a common postglacial colonization history of shelf populations. However, based on genome‐wide outlier loci, we uncovered signatures of population substructuring among the European continental shelf populations, i.e., suggesting signs of ongoing selection. Genome‐wide selection analyses (xp‐EHH) and the identification of genes within genomic regions of recent selective sweeps—overlapping with the outlier loci—suggest that these represent the signs of divergent selection. Our findings provide support for genomic divergence driven by local adaptation in the face of high gene flow and elucidate the relative importance of demographic history versus adaptive divergence in shaping the contemporary population genetic structure of a marine teleost. The role of the putative inversion(s) in the substructuring—and potentially ongoing adaptation—was seemingly not substantial.
Metal oxide semiconductors for gas sensing
Authors: Goel Neeraj , Kunal Kishor , Kushwaha Aditya , Kumar Mahesh 
Published: December 2022

AbstractThe usage of the gas sensor has been increasing very rapidly in the industry and in daily life for various potential applications. In the recent years, metal oxide semiconductors (MOS) become the primary choice for designing highly sensitive, stable, and low‐cost real‐life applications‐based gas sensors due to their inherent physical and chemical properties. Researchers have proposed numerous sensing mechanisms to explain the functionality of MOS‐based gas sensors. In this review, we have comprehensively covered different sensing mechanisms used for MOS. We have also discussed different parameters affecting the sensitivity and selectivity of the gas sensors. Moreover, the different techniques used to enhance the gas sensing response of MOS‐based sensors are also extensively covered. And finally, we give our prospective on recent opportunities and challenges on the future applications of MOS‐based gas sensors.
Cognitive and clinical gender‐related differences among binge‐spectrum eating disorders: Analysis of therapy response predictors
Authors: Mallorquí‐Bagué Núria , Lozano‐Madrid María , Granero Roser , Mestre‐Bach Gemma , Vintró‐Alcaraz Cristina , Sánchez Isabel , Jiménez‐Murcia Susana , Fernández‐Aranda Fernando 
Published: December 2022

AbstractObjectiveThis study assessed gender‐related differences in executive functions (decision‐making, inhibitory control and cognitive flexibility), personality traits and psychopathological symptoms in binge‐spectrum eating disorders (EDs). Secondly, we aimed to separately explore the predictive value of gender and executive functions in treatment outcome.MethodA battery of self‐reported and neurocognitive measures were answered by a sample of 85 patients (64 females) diagnosed with a binge‐spectrum ED (41 BN; 44 binge eating disorder).ResultsData showed gender‐related differences in executive functioning, displaying women lower inhibitory control and lower cognitive flexibility than men. Regarding personality traits and psychopathology symptoms, women presented higher reward dependence and cooperativeness, as well as more drive for thinness, body dissatisfaction, bulimia, and somatisation symptoms than men. Finally, worse executive functioning, particularly having lower ability in concept formation seems to predict worse treatment outcomes and dropout in these patients.ConclusionsWe described gender specific neuropsychological, personality and psychopathological impairments in patients with binge‐spectrum EDs. Moreover, difficulties in executive functioning might have an impact on treatment response, since patients with a lower ability in concept formation are less likely to benefit from treatment. The present results can help improving current treatment approaches by tackling gender and individual differences.
Efficient identification of trait‐associated loss‐of‐function variants in the UK Biobank cohort by exome‐sequencing based genotype imputation
Authors: Yu Wen‐Yuan , Yan Shan‐Shan , Zhang Shu‐Han , Ni Jing‐Jing , Bin‐Li  , Pei Yu‐Fang , Zhang Lei 
Published: December 2022

AbstractThe large‐scale open access whole‐exome sequencing (WES) data of the UK Biobank ~200,000 participants is accelerating a new wave of genetic association studies aiming to identify rare and functional loss‐of‐function (LoF) variants associated with complex traits and diseases. We proposed to merge the WES genotypes and the genome‐wide genotyping (GWAS) genotypes of 167,000 UKB homogeneous European participants into a combined reference panel, and then to impute 241,911 UKB homogeneous European participants who had the GWAS genotypes only. We then used the imputed data to replicate association identified in the discovery WES sample. The average imputation accuracy measure r2 is modest to high for LoF variants at all minor allele frequency intervals: 0.942 at MAF interval (0.01, 0.5), 0.807 at (1.0 × 10−3, 0.01), 0.805 at (1.0 × 10−4, 1.0 × 10−3), 0.664 at (1.0 × 10−5, 1.0 × 10−4) and 0.410 at (0, 1.0 × 10−5). As applications, we studied associations of LoF variants with estimated heel BMD and four lipid traits. In addition to replicating dozens of previously reported genes, we also identified three novel associations, two genes PLIN1 and ANGPTL3 for high‐density‐lipoprotein cholesterol and one gene PDE3B for triglycerides. Our results highlighted the strength of WES based genotype imputation as well as provided useful imputed data within the UKB cohort.