bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular dynamics simulations of the interaction between graphene and lubricating oil molecules
Authors: Hu Xianguo , Qiu Feng , Song Hui , Feng Weimin , Yang Zhiquan , Zhang Fei 
Published: November 2022

Abstract
The microscopic interaction between graphene and liquid lubricating oil molecules significantly affects the rheological and tribological properties of the solid-liquid lubricating system. In this study, the interaction between graphene and six kinds of alkane oil droplets with different chain lengths was investigated by molecular dynamics simulations. Interaction energy, atomic concentration distribution, mean square distribution, curvature, centroid, and inclination angle were used to quantitatively describe the effect of interaction differences on lubricating performance. The results demonstrated that with the increase of the carbon chain length, the alkane molecules transformed from a spherical oil droplet model to an ordered layered structure. At the same time, the interaction energy and the angle with the Z coordinate axis were further increased. The self-diffusion movement and the degree of molecular bending were reduced during the interaction, indicating that long-chain alkane molecules interact strongly with graphene, and a dense bilayer adsorption film was formed by horizontal adsorption on the surface of graphene, thus exerting a good lubricating effect. In addition, it was found that the increase in temperature was beneficial to the occurrence of the adsorption process, but high temperature is not conducive to the stable adsorption of alkane molecules on the surface of graphene.
Distributed Compact Plasma Reactor Sterilization for Planetary Protection in Space Missions
Authors: Choudhury Bhaswati , Revazishvili Tamara , Lozada Maria , Roy Sarthak , Mastro Emma Noelle , Portugal Sherlie , Roy Subrata 
Published: November 2022

Abstract
This paper presents a proof-of-concept study establishing effectiveness of the Active Plasma Sterilizer (APS) for sterilization in planetary protection. The APS uses Compact Portable Plasma Reactors (CPPRs) to produce surface dielectric barrier discharge, a type of cold plasma, using ambient air to generate and distribute reactive species like ozone used for decontamination. Sterilization tests were performed with pathogenic bacteria (Escherichia coli and Bacillus subtilis) on materials (Aluminum, Polycarbonate, Kevlar and Orthofabric) relevant to space missions. Results show that the APS can achieve 4 to 5 log reductions of pathogenic bacteria on four selected materials, simultaneously at 11 points within 30 minutes, using power of 13.2 +/- 2.22 W. Spatial sterilization data shows the APS can uniformly sterilize several areas of a contaminated surface within 30 minutes. Ozone penetration through Kevlar and Orthofabric layers was achieved using the CPPR with no external agent assisting penetration. Preliminary material compatibility tests with SEM analysis of the APS exposed materials showed no significant material damage. Thus, this study shows the potential of the APS as a lightweight sustainable sterilization technology for planetary protection with advantages of uniform spatial decontamination, low processing temperatures, low exposure times, material compatibility and the ability to disinfect porous surfaces.
Estimates of building-specific average annual loss reveal insights into U.S. homeowner flood risk
Authors: Rahim Md Adilur , Friedland Carol J , Mostafiz Rubayet Bin , Rohli Robert V , Bushra Nazla 
Published: November 2022

Abstract
Accurate economic loss assessment for natural hazards is vital for planning, mitigation, and actuarial purposes. The widespread and costly nature of flood hazards, with the economically disadvantaged disproportionately victimized, makes flood risk assessment particularly important. Here, flood risk is assessed as incurred by the homeowner vs. by the flood insurer for insured U.S. properties through the derivation of average annual loss (AAL). AAL is estimated and partitioned using Monte Carlo simulation at the individual home scale considering insurance coverage and deductible, and home freeboard (i.e., elevation of the first floor above the base flood elevation), to determine the homeowners’ AAL proportion (i.e., apportionment factor) for building and contents, distinguished from that borne by the insurer. In general, AAL estimates suggest that a large portion of the U.S. property flood risk is borne by flood insurer. The flood insurance policy deductible directly influences the apportionment factor whereby higher deductibles leave homeowners with higher annual risk; however, the apportionment factor remains relatively insensitive to coverage values, especially for higher coverage amounts. The homeowner’s flood risk is further reduced by freeboard, with AAL following an exponential decay trend as freeboard increases, but the apportionment factor appears relatively insensitive to freeboard. These results reveal new perspectives about how flood insurance protects homeowners from flood risk. In general, results inform the proactive decision-making process that allows homeowners to self-assess their degree of preparation and vulnerability to the devastating economic impacts of flood.
Simultaneous Multimodal fNIRS-EEG Recordings Reveal New Insights in Neural Activity During Motor Execution, Observation, and Imagery
Authors: Su Wan-Chun , Dashtestani Hadis , Miguel Helga O. , Condy Emma , Buckley Aaron , Park Soongho , Perreault John B. , Nguyen Thien , Zeytinoglu Selin , Millerhagen John , Fox Nathan , Gandjbakhche Amir 
Published: November 2022

Abstract
Motor execution, observation, and imagery are important skills used in motor learning and rehabilitation. The neural mechanisms underlying these cognitive-motor processes are still poorly understood. We used a simultaneous recording of functional near-infrared spectroscopy (fNIRS) and electroencephalogram (EEG) to elucidate the differences in neural activity across three conditions requiring these processes. Additionally, we used a new method called structured sparse multiset Canonical Correlation Analysis (ssmCCA) to fuse the fNIRS and EEG data and determine the brain regions of neural activity consistently detected by both modalities. Unimodal analyses revealed differentiated activation between conditions; however, the activated regions did not fully overlap across the two modalities (fNIRS: left pre- and post-central, right angular gyrus; EEG: bilateral central, right frontal, and parietal). These discrepancies might be because fNIRS and EEG detect different signals. Using fused fNIRS-EEG data, we consistently found activation over the left inferior parietal lobe, superior marginal gyrus, and post-central gyrus during all three conditions, suggesting that our multimodal approach identifies a shared neural region associated with the Action Observation Network (AON). This study highlights the strengths of using the multimodal fNIRS-EEG fusion technique for studying AON. Neural researchers should consider using the multimodal approach to validate their findings.
Denosumab for Osteoporosis in Patients With Primary Hyperparathyroidism and Renal Insufficiency
Authors: Gronskaia Sofia , Belaya Zhanna , Rozhinskaya Liudmila , Mamedova Elizaveta , Vorontsova Maria , Solodovnikov Alexander , Golounina Olga , Melnichenko Galina 
Published: November 2022

Abstract
Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia. The only curative treatment is parathyroidectomy. However, patients are often ineligible or decline surgery. Denosumab (Dmab) is an antiresorptive pharmaceutical alternative. The effects of exposure to Dmab in subjects with chronic kidney disease (CKD) and PHPT are unknown.
Purpose:We aimed to assess the efficacy and safety of denosumab in postmenopausal women with PHPT- related osteoporosis and CKD.
Methods: Women over 50 years of age with PHPT or postmenopausal osteoporosis (PMO) were retrospectively recruited into this longitudinal study. These PHPT and PMO groups were further categorized into four subgroups based on the presence of CKD (Glomerular filtration rate (GFR) <60 mL/min/1.73mBI): patients with PHPT with and without CKD and patients with PMO with and without CKD. All patients were given denosumab over 24 months due to verified osteoporosis. The primary outcomes were changes in bone mineral density (BMD) and serum calcium levels.
Results: 145 postmenopausal women median age 69 [63;77] were recruited and assigned to one of the subgroups. Denosumab treatment significantly increased BMD (median ΔT-score: L1-L4 +0.65 (p<0.001), femur neck +0.3 (p=0.012); radius 33% +0.2 (p<0.05)) in PHPT-related osteoporosis and CKD at 24 months. Changes in BMD were similar in all study groups compared to baseline. A marked decline in calcium was noted in the primary study group of PHPT with CKD (median ΔCa = -0.24 mmol/L p<0.001), compared to PHPT without CKD (median ΔCa = -0.08 mmol/L p<0.001) and PMO with or without CKD. Denosumab treatment was well-tolerated with no serious adverse events.
Conclusion: Denosumab treatment was similarly effective at increasing BMD in patients with PHPT and PMO with and without renal insufficiency. The calcium lowering effects of denosumab were most significant in patients with PHPT and CKD. The safety of denosumab did not differ among participants with and without CKD.
EcoDataCube.eu: Analysis-Ready Open Environmental Data Cube for Europe
Authors: Witjes Martijn , Parente Leandro Leal , Krizan Josip , Antonic Luka , Hengl Tomislav 
Published: November 2022

Abstract
The paper describes production steps and accuracy assessment of an analysis-ready open
environmental data cube (2000--2021+) for continental Europe; at working resolutions
from 10~m to 30~m and with quarterly to annual estimates. The data cube is based on
processing and harmonizing earth observation (EO) images: Landsat GLAD ARD (2000-
-2020+), Sentinel-2 images (2017--2021+) and Digital Elevation data. These datasets were
created with accessibility, user-friendliness, interoperability and synthesis in mind. This
has required systematic spatiotemporal harmonization, efficient compression, and
imputation of missing values. To ensure a missing value percentage below 1%, the EO
data was first aggregated into 4 quarterly periods approximating the 4 seasons common in
Europe (winter, spring, summer and autumn), and then split into three percentiles (25th,
50th and 75th). Remaining missing data in the Landsat time-series was imputed with a
temporal moving window median (TMWM) approach. The accuracy assessment shows
TMWM gap-ûlling achieves higher performance in Southern Europe, and lower performance
in mountainous regions such as the Scandinavian Mountains, the Alps, and the Pyrenees.
The intended uses of the EcoDataCube platform include vegetation, soil, land cover and
land use mapping projects, environmental monitoring and automated generation of data
for statistical oûces including Eurostat. Combining all four datasets produced in this work
(DTM, Landsat 30m, Sentinel-2 30m and Sentinel-2 10m) yields the highest land cover
classification accuracy, with different datasets improving the results for different land
cover classes. The Environmental data cube for Europe is available under CC-BY license as
Cloud-Optimized GeoTIFFs (ca. 12TB in size) through STAC and the EcoDataCube data
portal.
Influence of Internal and External Imaging Plane Inclination on Assessment of Trochlear Depth, Sulcus Angle, And Facet Asymmetry in the Setting of Trochlear Dysplasia: A Cadaveric Study
Authors: Vranken Kristel , Doring Seema , Buls Nico , Vanlauwe Johan , Germonpré Sofie , Provyn Steven , De Smet Aron , De Maeseneer Michel 
Published: November 2022

Abstract
Purpose
(1) to assess the influence of internal or external imaging plane inclination on measurement of sulcus angle, trochlear depth, and facet asymmetry on transverse cross-sectional images. (2) to assess the effect of measurement level (height) on these respective parameters.
Materials and methods
Twenty dry femurs (9 left, 11 right) were imaged with CT. A 3D dataset was obtained from which axial images were reconstructed in the ideal plane without inclination as well as with 8° of medial and lateral inclination. Sulcus angle, trochlear depth, and facet asymmetry were measured on the 3 image sets. In addition, the measurements were performed at 5 mm and 10 mm from the superior margin of the medial trochlear facet. Statistical analysis consisted of Wilcoxon test and calculation of measurement variation.
Results
There were no statistically significant differences between the indicated measurements on the reference set compared to medial or lateral inclination. All measurements were significantly different depending on measurement height.
Conclusion
Medial or lateral inclination in the transverse imaging plane of 8 ° does not influence the values of typical parameters used for assessment of trochlear dysplasia. The measurement height has a significant influence, and a consensus should be found as to which is the optimal measurement height.
UnidecNMR: Automatic peak detection for NMR spectra in 1-4 dimensions
Authors: Buchanan Charles , Karunanithy Gogulan , Tkachenko Olga , Barber Michael , Marty Michael , Baldwin Andrew 
Published: November 2022

Abstract

To extract information from NMR experiments, users need to identify the number of resonances in the spectrum,together with characteristic features such as chemical shiftsand intensities. In many applications, particularly those involving biomolecules, this procedure is typicallya manual and laborious process. While manyalgorithms are available to tackle this problem, theirperformance tends to be inferior to that of an experienced user.Here,weintroduce UnidecNMR, which identifies resonances in NMR spectra using deconvolution. We demonstrate itsfavourable performance on 1 and 2D simulatedspectra,strongly overlapped 1D spectra of oligosaccharides and2D HSQC,3D HNCO, 3DHNCA and 3/4D methyl-methyl NOE experimental spectra from a range of proteins. UnidecNMR outperforms a number of freely available algorithms and provides results that are either of similar quality to those generated manually, or in the case of NOE data, superior. We demonstrate that introducing additionalrestraints, such as a 2D peak listwhen analysing 3 and 4D data and incorporating reflection symmetryin NOE analysisfurther improves the results. UnidecNMR outputs a back-calculated spectrum and a peak list, both of which can be easily examined using the supplied GUI. The software allows interactive processing of raw data using nmrPipe. UnidecNMR is free for academic use and can function as either part of an automatic pipeline or provide an excellent ‘first guess’ of peak locations as part of a semi-automatic analysis.
The Presidential period in the United States of America and stock returns, evidence from Iran
Authors: Dadaneh Foad Zamani , Khezre Mehran , Haghighat Hamid 
Published: November 2022

Abstract
The most important event in the world is the presidential election in the United States of America, to which the stock markets of many countries react. This reaction may differ according to the presidential period in which one of the candidates is selected. Accordingly, our research aims to investigate the effect of two presidential periods with two different parties on the stock returns of companies listed on the Tehran Stock Exchange. Hence, using the analysis of 650 firm-year observations for the first period and 1095 firm-year observations for the second period, for two different presidential periods, respectively, the presidency of Barack Obama (Democratic Party) and Donald Trump (Republican Party), we find that the elections and the presidential period of both parties have a negative, significant effect on the annual cumulative stock returns of companies. Results show that investors react to events such as elections, even in emerging markets like Iran.
A novel weevil-transmitted tymovirus found in mixed infection on hollyhock
Authors: Mahillon Mathieu , Brodard Justine , Kellenberger Isabelle , Blouin Arnaud , Schumpp Olivier 
Published: November 2022

Abstract
Leaves of hollyhock (Alcea rosea) exhibiting vein chlorosis and yellow mosaic symptoms were collected at public sites in Lausanne and Nyon, two cities of western Switzerland. Classical diagnostic methods untangled in samples from both sites the mixed infections of a novel isometric virus, tentatively named “Alcea yellow mosaic virus” (AYMV) with the carlavirus Gaillardia latent virus. A new potyvirus was also identified in samples from Nyon. A combination of Illumina, Nanopore and Sanger sequencing was necessary to assemble the full-length genome of AYMV, revealing an exceptionally high cytidine content and other features typically associated with members of the genus Tymovirus. The host range of AYMV was found to be restricted to mallows, including ornamentals as well as economically important plants. Phylogenetic analyses further showed that AYMV belongs to a Tymovirus subclade that also gathers the other mallow-infecting members. The virus was readily transmitted by sap inoculation, and the weevil species Aspidapion radiolus was evidenced as a vector. Transmission assays using another weevil or other insect species did not succeed, and seed transmission was not observed.
'Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity’
Authors: Shukla Rahul , Ahuja Richa , Beesetti Hemalatha , Garg Amit , Aggrawal Charu , Chaturvedi Shivam , Nayyar Kaushal , Arora Upasana , Lal Altaf A. , Khanna Navin 
Published: November 2022

Abstract
Dengue Virus (DENV) infection has increased worldwide, with over 400 million infections annually, and has become a serious public health concern. Several drug candidates, new and repurposed, have failed to meet the primary efficacy endpoints. We have recently shown that Aqueous Extract of the stem of Cocculus hirsutus (AQCH) was effective in vitro and in vivo against DENV and was safe in humans. We now report that an active ingredient of AQCH, Sinococuline, protects against the antibody-mediated secondary-DENV infection in the AG129 mouse model. DENV infection markers were assessed, viz. serum viremia and vital organs pathologies- viral load, proinflammatory cytokines and intestinal vascular leakage. The treatment with Sinococuline at 2.0 mg/kg/dose, twice a day (BID), was the most effective in protecting the severely DENV-infected AG129 mice. Also, this dose effectively reduced serum viremia and tissue-viral load and inhibited the elevated expression levels of proinflammatory cytokines (TNF-α & IL-6) in several vital organs. Based on these findings, it could be explored further for pre-clinical and clinical developments for the treatment of dengue.
The Prevalence and Risk Factors of Autistic Experiences of Interpersonal Violence: A Systematic Review and Meta-Analysis
Authors: Cooke Kassandrah , Ridgway Kathryn , Westrupp Elizabeth , Hedley Darren , Hooley Merrilyn , Stokes Mark A. 
Published: November 2022

AbstractBackground:Interpersonal violence is a widespread yet understudied issue in autism spectrum disorder (henceforth, ‘autism’). While themultiple minority stressmodel suggests gender marginalised groups (e.g., females, transgender, non-binary) are at greater risk, research investigating this model among autistic populations is limited. The current review and meta-analysis examined the prevalence and risk factors associated with interpersonal violence among autistic individuals of varying gender identities.Methods:A systematic database search identified 42 studies examining: (1) a combination of physical, sexual, or psychological violence; (2) physical violence; (3) sexual violence; (4) psychological violence; (5) traditional bullying; (6) cyberbullying; and (7) homicide among autistic people across all age groups and support needs levels, compared by gender. A random-effects meta-analysis with pooled data from 13 eligible studies was undertaken, comprising 4,498 participants (malesn= 3,472; femalesn= 1,026) aged between 2 to 56 years.Results:Analyses indicated overall violence prevalence is increased among females compared to males,d= 0.44,p< .001; 95% CI [0.24, 0.65], across all ages and support needs levels. The largest effect was for childhood maltreatment and negative social events during adulthood,d= 1.07,p< .05, [0.20, 1.93]. Narrative synthesis of 37 studies indicated autistic people were significantly more likely to be victimised by carers and peers compared to non-autistic people. Key risk factors included belonging to a gender or racial minority, having co-occurring mental health issues, and coming from a low-income household.Limitations:The generalisability of findings was limited by the shortage of literature about autistic experiences of violence not involving bullying, participants with high needs, and participants outside of the binary gender. This may also contribute to the high level of heterogeneity (I2= 87%) found.Conclusions:The results of this review and meta-analysis indicate that interpersonal violence is a pressing issue among autistic people, who appear to face concerningly high rates of victimisation and poly-victimisation across the life course, particularly among multiply marginalised people (i.e., gender, race, mental health, economic). This underscores the importance of exploring violence from an intersectional perspective, across individual and societal contexts, providing support for multiple minority theory.
Exploring the expression and the prognosis of mismatch repair protein and PD-L1 in colorectal cancer
Authors: Zhang Yaping , Han Lu , Zhang Qun , Liu Zhihao , Niu Haiqing , Li Li , Hu Jing , Shi Xiao , Ding Zhou , Qian Xiaoping 
Published: November 2022

Abstract
Background Colorectal cancer (CRC) is one of the most common malignancies of the gastrointestinal tract, it is very important to find biomarkers that can accurately predict the therapeutic efficacy to accurately grasp the development of the disease, this study aims to investigate the expression and clinical significance of mismatch repair (MMR) protein and programmed cell death 1 ligand 1 (PD-L1) in samples from surgically resected colorectal cancer (CRC) patients. Methods A total of 272 surgically resected CRC patients attending at Drum Tower Hospital of Nanjing University School of Medicine from January 2018 to May 2022 were retrospectively included in the study. Collect surgical excision samples from all patients and record in detail the general data, clinicopathological data, and imaging data of all subjects. Immunohistochemistry (IHC) and Western Blot were used to detect the expression of MSH2, MSH6, MLH1, and PMS2 proteins in the tumor tissue and normal tissue adjacent to the cancer of the resected samples, respectively. X2 test was used to investigate the correlation between the expression of MMR protein and PD-L1 in CRC tumor tissues and the clinicopathological characteristics, then further analyzed the correlation between the deletion of four MMR proteins in CRC tumor tissues, and finally investigated the relationship between the expression of MMR protein and PD-L1 and the prognosis of CRC patients by survival curve and Log Rank test. Results 1. MMR protein expression deletion was correlated with tumor location, differentiation degree, and TNM stage (P < 0.05); while PD-L1 expression was only correlated with TNM stage (P < 0.05). 2. Correlation analysis of MMR protein isoform expression deletion found that PMS2 expression deletion was significantly correlated with MLH1 expression deletion, similarly, MSH2 expression deletion was significantly correlated with MSH6 expression deletion was significantly correlated with MSH6 expression deletion (P < 0.05), in addition, PMS2 expression deletion was also correlated with PD-L1 expression (P < 0.05). 3. The survival time was shorter in dMMR patients compared with pMMR patients. Conclusion Deletion of MMR protein expression and expression of PD-L1 are closely related to clinicopathological characteristics and prognosis of CRC patients, maybe MMR and PD-L1can be potential biomarkers.