bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alexia and agraphia in Japanese
Authors: Suzuki Kyoko 
Published: May 2022

AbstractDissociated performance in the reading/writing of kanji (morphogram) and kana (phonogram) in alexia and agraphia in Japanese has attracted attention because kanji and kana differently convey semantics, orthography, and phonology. Although the dissociation between kanji and kana is relative, but not absolute, detailed case studies, in addition to recent neuroimaging and neurophysiological studies, have revealed the partially separable mechanisms of the kanji and kana writing systems. Kanji words are processed mainly, not exclusively, via the orthographic–semantic route, and kana words are processed via both orthographic–semantic and phonological routes. Pure alexia with lesions in the left medial occipital lobe and splenium shows alexia for both kanji and kana, but at the chronic stage, alexia for either kanji or kana may remain depending on the compensatory mechanism. The left occipitotemporal area is important for reading/writing. The slightly different location and extent of lesions are associated with distinct symptoms: kanji alexia with the lesion in the mid‐fusiform gyrus (visual word form area; VWFA), kana alexia with lesions posterior to VWFA, and kanji alexia with kanji agraphia with lesions lateral to VWFA. The left angular gyrus has traditionally been considered important for writing. However, it is unclear whether the crucial site is the angular gyrus or the cortical and subcortical regions adjacent to it. In neurodegenerative diseases, reading/writing abilities are differentially impaired depending on the specific distribution of neuronal degeneration in each disease. Examining the reading/writing abilities of kanji and kana can facilitate understanding of the writing system and related disorders.
PEAPOD repressors modulate and coordinate developmental responses to light intensity in Arabidopsis
Authors: White Derek W. R. 
Published: May 2022

Summary

Higher plants adapt to different light intensities by altering hypocotyl elongation, stomatal density, seed size, and flowering time. Despite the importance of this developmental plasticity, knowledge of the underlying genetic and molecular mechanisms modulating and coordinating responses to light intensity remains incomplete. Here, I report that in Arabidopsis the PEAPOD (PPD) repressors PPD1 and PPD2 prevent exaggerated responses to light intensity.

Genetic and transcriptome analyses, of a ppd deletion mutant and a PPD1 overexpression genotype, were used to identify how PPD repressors modulate the light signalling network.

A ppd1/ppd2 deletion mutant has elongated hypocotyls, elevated stomatal density, enlarged seed, and delayed flowering, whereas overexpression of PPD1 results in the reverse. Transcription of both PPD1 and PPD2, upregulated in low light and downregulated in higher light, is activated by PHYTOCHROME INTERACTING FACTOR 4. I found PPDs modulate light signalling by negative regulation of SUPPRESSOR OF phyA‐105 (SPA1) transcription. Whereas PPDs coordinate many of the responses to light intensity – hypocotyl elongation, flowering time, and stomatal density – by repression/de‐repression of SPA1, PPD regulation of seed size occurs independent of SPA1.

In conclusion PPD repressors modulate and coordinate developmental responses to light intensity by altering light signal transduction.
OSCA1 is an osmotic specific sensor: a method to distinguish Ca2+‐mediated osmotic and ionic perception
Authors: Pei Songyu , Liu Yuantao , Li Wenke , Krichilsky Bryan , Dai Shiwen , Wang Yan , Wang Xi , Johnson Douglas M. , Crawford Bridget M. , Swift Gary B. , Vo‐Dinh Tuan , Pei Zhen‐Ming , Yuan Fang 
Published: May 2022

Summary

Genetic mutants defective in stimulus‐induced Ca2+ increases have been gradually isolated, allowing the identification of cell‐surface sensors/receptors, such as the osmosensor OSCA1. However, determining the Ca2+‐signaling specificity to various stimuli in these mutants remains a challenge. For instance, less is known about the exact selectivity between osmotic and ionic stresses in the osca1 mutant.

Here, we have developed a method to distinguish the osmotic and ionic effects by analyzing Ca2+ increases, and demonstrated that osca1 is impaired primarily in Ca2+ increases induced by the osmotic but not ionic stress.

We recorded Ca2+ increases induced by sorbitol (osmotic effect, OE) and NaCl/CaCl2 (OE + ionic effect, IE) in Arabidopsis wild‐type and osca1 seedlings. We assumed the NaCl/CaCl2 total effect (TE) = OE + IE, then developed procedures for Ca2+ imaging, image analysis and mathematic fitting/modeling, and found osca1 defects mainly in OE.

The osmotic specificity of osca1 suggests that osmotic and ionic perceptions are independent. The precise estimation of these two stress effects is applicable not only to new Ca2+‐signaling mutants with distinct stimulus specificity but also the complex Ca2+ signaling crosstalk among multiple concurrent stresses that occur naturally, and will enable us to specifically fine tune multiple signal pathways to improve crop yields.
Robust crisis communication in turbulent times: Conceptualization and empirical evidence from the United States
Authors: Zhong Wei , Hu Qian , Kapucu Naim 
Published: May 2022

AbstractDrawing on recent research on robust governance, we conceptualize robust crisis communication as a dynamic process centered on evolving public communication demands. We propose a three‐dimensional measurement for empirically examining the robustness of government crisis communication in the context of the COVID‐19 pandemic. We collected 43,642 Twitter messages posted by 50 state governors in the United States from January 1 to June 30, 2020. We applied machine learning algorithms to code the voluminous Twitter data based on messaging topics, sentiments, and interactions. This study found an overall low level of robustness in the governors' crisis communication. Governors most frequently posted reputation management tweets, followed by tweets about the government's handling of the pandemic. This research presents empirical evidence for the heavy influence of politics on governors' crisis communication strategies and highlights the need to understand and build robust crisis communication.摘要本文借鉴稳健性治理的最新相关研究，提出稳健性危机沟通的概念，将其界定为聚焦于满足危机中持续变化的公众沟通需求的动态沟通过程与模式。基于此概念，本文以新型冠状病毒肺炎疫情中的危机沟通为例，构建三维测量方法，用以检验政府危机沟通在内容主题、情感表达和对话互动三方面的稳健程度。本文收集美国50个州长在2020年1月1日至2020年6月30日期间发布的43,642条推特信息，并应用机器学习对所有信息的主题、情感和互动特征进行编码分析。本文发现美国州长危机沟通的稳健性程度总体偏低。美国州长最经常发布与声誉管理相关的推文，其次是政府的疫情防控措施。文章进一步阐释与例证政治因素对州长危机沟通策略的深刻影响，并强调政府部门理解与践行稳健性风险沟通的必要性与重要性。
Milroy disease with predominant preputial involvement
Authors: Pérez‐Bertólez Sonia , Alonso Verónica 
Published: May 2022

AbstractMilroy disease is a form of congenital primary lymphedema that usually affects the lower limbs. Predominant genital lymphedema in Milroy disease is uncommon and disabling. When conservative management is ineffective, surgical treatment becomes necessary. Here, we present a rare case of congenital primary penile lymphedema in a 4‐year‐old child.
Capturing Dynamic Performance in a Cognitive Model: Estimating ACT‐R Memory Parameters With the Linear Ballistic Accumulator
Authors: van der Velde Maarten , Sense Florian , Borst Jelmer P. , van Maanen Leendert , van Rijn Hedderik 
Published: May 2022

AbstractThe parameters governing our behavior are in constant flux. Accurately capturing these dynamics in cognitive models poses a challenge to modelers. Here, we demonstrate a mapping of ACT‐R's declarative memory onto the linear ballistic accumulator (LBA), a mathematical model describing a competition between evidence accumulation processes. We show that this mapping provides a method for inferring individual ACT‐R parameters without requiring the modeler to build and fit an entire ACT‐R model. Existing parameter estimation methods for the LBA can be used, instead of the computationally expensive parameter sweeps that are traditionally done. We conduct a parameter recovery study to confirm that the LBA can recover ACT‐R parameters from simulated data. Then, as a proof of concept, we use the LBA to estimate ACT‐R parameters from an empirical dataset. The resulting parameter estimates provide a cognitively meaningful explanation for observed differences in behavior over time and between individuals. In addition, we find that the mapping between ACT‐R and LBA lends a more concrete interpretation to ACT‐R's latency factor parameter, namely as a measure of response caution. This work contributes to a growing movement towards integrating formal modeling approaches in cognitive science.
Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog
Authors: Buseman Miranda , Blong April E. , Walton Rebecca A. L. 
Published: May 2022

AbstractObjectiveTo report the use of manual therapeutic plasma exchange (TPE) in a dog with severe carprofen toxicity.SummaryA 12‐year‐old neutered female Pembroke Welsh Corgi weighing 20 kg was evaluated after ingesting 223 mg/kg of carprofen. Emesis was attempted with apomorphine at the primary care veterinarian but was unsuccessful, and a dose of activated charcoal with sorbitol was administered. On presentation to the referral center, approximately 8 hours after ingestion, the dog's physical examination revealed mild abdominal discomfort but was otherwise unremarkable. Treatment consisted of a combination of supportive care including activated charcoal with sorbitol, cholestyramine, IV lipid emulsion, and manual TPE. Blood samples were collected prior to the initiation of manual TPE and at the completion of 12 exchange cycles. Carprofen levels were determined by high‐pressure liquid chromatography. A 57% decrease in carprofen levels was achieved with the combination of activated charcoal, cholestyramine, IV lipid emulsion, and manual TPE. The dog did not develop organ dysfunction secondary to toxicity and was discharged 4 days after ingestion.New or Unique Information ProvidedThis report describes the successful decrease of plasma carprofen in a dog with the combination of decontamination techniques and manual TPE. While TPE has been previously reported as a successful therapeutic in dogs with nonsteroidal anti‐inflammatory toxicity, including carprofen, equipment and expertise of this platform is not readily available. Manual TPE is technically simple and can be performed in any hospital with a large blood centrifuge.
Modeling and Reinforcement Learning Control of an Autonomous Vehicle to Get Unstuck From a Ditch
Authors: Manring Levi H. , Mann Brian P. 
Published: May 2022

Abstract
Autonomous vehicle control approaches are rapidly being developed for everyday street-driving scenarios. This article considers autonomous vehicle control in a less common, albeit important, situation “a vehicle stuck in a ditch.” In this scenario, a solution is typically obtained by either using a tow-truck or by humans rocking the vehicle to build momentum and push the vehicle out. However, it would be much more safe and convenient if a vehicle was able to exit the ditch autonomously without human intervention. In exploration of this idea, this article derives the governing equations for a vehicle moving along an arbitrary ditch profile with torques applied to front and rear wheels and the consideration of four regions of wheel-slip. A reward function was designed to minimize wheel-slip, and the model was used to train control agents using Probabilistic Inference for Learning COntrol (PILCO) and deep deterministic policy gradient (DDPG) reinforcement learning (RL) algorithms. Both rear-wheel-drive (RWD) and all-wheel-drive (AWD) results were compared, showing the capability of the agents to achieve escape from a ditch while minimizing wheel-slip for several ditch profiles. The policy results from applying RL to this problem intuitively increased the momentum of the vehicle and applied “braking” to the wheels when slip was detected so as to achieve a safe exit from the ditch. The conclusions show a pathway to apply aspects of this article to specific vehicles.
Nanoindentation Size Effects in Lithiated and Sodiated Battery Electrode Materials
Authors: Papakyriakou Marc , Lu Mu , Xia Shuman 
Published: May 2022

Abstract
Deformation and stress in battery electrode materials are strongly coupled with diffusion processes, and this coupling plays a crucial role in the chemical and structural stability of these materials. In this work, we performed a comparative study of the mechanical characteristics of two model materials (lithiated and sodiated germanium (Ge)) by nanoindentation. A particular focus of the study was on the indentation size effects and harnessing them to understand the chemo-mechanical interplay in these materials. While the quasi-static measurement results showed no significant size dependence, size effects inherent in the nanoindentation creep response were observed and utilized to investigate the deformation mechanism of each material. Supplemented by computational chemo-mechanical modeling, we found that lithiated Ge creeps through a stress-gradient-induced diffusion (SGID) mechanism but a model combining the SGID and conventional shear transformation deformation (STD) mechanisms was needed to capture the creep behavior of sodiated Ge. Broadly, this work reveals the importance of stress-diffusion coupling in governing the deformation of active electrode materials and provides a quantitative framework for characterizing and understanding such coupling.
Probabilistic Digital Twin for Additive Manufacturing Process Design and Control
Authors: Nath Paromita , Mahadevan Sankaran 
Published: May 2022

Abstract
This paper proposes a detailed methodology for constructing an additive manufacturing (AM) digital twin for the laser powder bed fusion (LPBF) process. An important aspect of the proposed digital twin is the incorporation of model uncertainty and process variability. A virtual representation of the LPBF process is first constructed using a physics-based model. To enable faster computation required in uncertainty analysis and decision-making, the physics-based model is replaced by a cheaper surrogate model. A two-step surrogate model is proposed when the quantity of interest is not directly observable during manufacturing. The data collected from the monitoring sensors are used for diagnosis (of current part quality) and passed on to the virtual representation for model updating. The model updating consists of Bayesian calibration of the uncertain parameters and the discrepancy term representing the model prediction error. The resulting digital twin is thus tailored for the particular individual part being produced and is used for probabilistic process parameter optimization (initial, before starting the printing) and online, real-time adjustment of the LPBF process parameters, in order to control the porosity in the manufactured part. A robust design optimization formulation is used to minimize the mean and standard deviation of the difference between the target porosity and the predicted porosity. The proposed methodology includes validation of the digital twin in two stages. Validation of the initial model in the digital twin is performed using available data, whereas data collected during manufacturing are used to validate the overall digital twin.
Inflated Cone Experiment for High-Throughput Characterization of Time-Dependent Polymer Membranes
Authors: Bugra Ozdemir Veli , Kwok Kawai 
Published: May 2022

Abstract
Long-term behavior of polymer membranes in the nonlinear regime is probed by strain histories under various stress levels. Current characterization methods for polymer membranes impose a uniform stress field and hence require a series of long-duration tests to be conducted, which poses a significant experimental challenge. Here, we present the inflated cone method to generate a continuous spectrum of strain histories under various stresses in a single experiment. By imposing a known stress gradient and utilizing a full-field strain measurement technique, the inflated cone method provides a high-throughput approach for extracting time-dependent data of polymer membranes. The method is suitable for studying nonlinear time-dependent deformations under a biaxial stress state. The stress range and ratio can be easily modulated by cone geometry design. We demonstrate the utility of the method through creep-recovery tests carried out on a polyethylene thin film. The proposed experimental method is highly beneficial for the development of nonlinear viscoelastic and viscoplastic models.
The jagged western edge of Laurentia: The role of inherited rifted lithospheric structure in subsequent tectonism in the Pacific Northwest
Authors: Tikoff B. , Kelso P. , Fayon A.K. , Gaschnig R. , Russo R.M. , Vervoort J. , Jicha B. , Kahn M.J. 
Published: May 2022

ABSTRACT
The rifted Precambrian margin of western Laurentia is hypothesized to have consisted of a series of ~330°-oriented rift segments and ~060°-oriented transform segments. One difficulty with this idea is that the87Sr/86Sri = 0.706 isopleth, which is inferred to coincide with the trace of this rifted margin, is oriented approximately N-S along the western edge of the Idaho batholith and E-W in northern Idaho; the transition between the N-S– and E-W–oriented segments occurs near Orofino, Idaho. We present new paleomagnetic and geochronologic evidence that indicates that the area around Orofino, Idaho, has rotated ~30° clockwise since ca. 85 Ma. Consequently, we interpret the current N-S–oriented margin as originally oriented ~330°, consistent with a Precambrian rift segment, and the E-W margin as originally oriented ~060°, consistent with a transform segment. Independent geochemical and seismic evidence corroborates this interpretation of rotation of Blue Mountains terranes and adjacent Laurentian block. Left-lateral motion along the Lewis and Clark zone during Late Cretaceous–Paleogene time likely accommodated this rotation. The clockwise rotation partially explains the presence of the Columbia embayment, as Laurentian lithosphere was located further west. Restoration of the rotation results in a reconstructed Neoproterozoic margin with a distinct promontory and embayment, and it constrains the rifting direction as SW oriented. The rigid Precambrian rift-transform corner created a transpressional syntaxis during middle Cretaceous deformation associated with the western Idaho and Ahsahka shear zones. During the late Miocene to present, the Precambrian rift-transform corner has acted as a fulcrum, with the Blue Mountains terranes as the lever arm. This motion also explains the paired fan-shaped contractional deformation of the Yakima fold-and-thrust belt and fan-shaped extensional deformation in the Hells Canyon extensional province.
Benchmark planes for Higgs-to-Higgs decays in the NMSSM
Authors: Ellwanger Ulrich , Hugonie Cyril 
Published: May 2022

AbstractWe present benchmark planes (or lines) with cross sections via gluon fusion for the processes $$H\rightarrow h+H_{S}$$

H
→
h
+

H
S

, resonant Higgs pair and triple Higgs production, $$A \rightarrow h+(A_S \rightarrow \gamma \gamma )$$

A
→
h
+
(

A
S

→
γ
γ
)

, $$A \rightarrow Z+ h$$

A
→
Z
+
h

and $$A \rightarrow Z+ H_{S}$$

A
→
Z
+

H
S

within the Next-to-Minimal Supersymmetric Standard Model. Moreover we propose new searches for $$H\rightarrow h+(H_{S} \rightarrow t{\bar{t}})$$

H
→
h
+
(

H
S

→
t

t

¯

)

, $$A \rightarrow Z+ (H_{S}\rightarrow h+h)$$

A
→
Z
+
(

H
S

→
h
+
h
)

and $$A \rightarrow Z+ (H_{S}\rightarrow t{\bar{t}})$$

A
→
Z
+
(

H
S

→
t

t

¯

)

for which possible cross sections are given. These allow the experimental collaborations to verify in the future which search channels cover yet unexplored regions of the parameter space. Expressions for the dominant contributions to trilinear Higgs couplings and Higgs–Z couplings are discussed which allow to identify the dominant processes contributing to a given final state.
How to understand the X(2900)?
Authors: Wang Bo , Zhu Shi-Lin 
Published: May 2022

AbstractIn this work, the S- and P-wave $$\bar{D}^*K^*$$

D

¯

∗

K
∗

interactions are studied in a coupled-channel formalism to understand the recently observed $$X_0(2900)$$

X
0

(
2900
)

and $$X_1(2900)$$

X
1

(
2900
)

at LHCb. The experimental event distributions can be well described, and two states with $$I(J^P)=0(0^+)$$

I

(

J
P

)

=
0

(

0
+

)

and $$0(1^-)$$

0
(

1
-

)

are yielded in a unified framework. The masses of the $$0^+$$

0
+

and $$1^-$$

1
-

states are consistent with the experimental data, but the width of the $$0^+$$

0
+

state is larger than that of the $$1^-$$

1
-

one. The $$X_1(2900)$$

X
1

(
2900
)

can be interpreted as the P-wave excitation of the ground-state $$X_0(2900)$$

X
0

(
2900
)

in the hadronic molecular picture. The S- and P-wave multiplets in the $$\bar{D}^*K^*$$

D

¯

∗

K
∗

system have many members, so the present peak in the $$D^-K^+$$

D
-

K
+

invariant mass distributions might contain multi substructures.
Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma
Authors: Saini Neeraj Y. , Swoboda David M. , Greenbaum Uri , Ma Junsheng , Patel Romil D. , Devashish Kartik , Das Kaberi , Tanner Mark R. , Strati Paolo , Nair Ranjit , Fayad Luis , Ahmed Sairah , Lee Hun Ju , Iyer Swaminathan P. , Steiner Raphael , Jain Nitin , Nastoupil Loretta , Loghavi Sanam , Tang Guilin , Bassett Roland L. , Jain Preetesh , Wang Michael , Westin Jason R. , Green Michael R. , Sallman David A. , Padron Eric , Davila Marco L. , Locke Frederick L. , Champlin Richard E. , Garcia-Manero Guillermo , Shpall Elizabeth J. , Kebriaei Partow , Flowers Christopher R. , Jain Michael D. , Wang Feng , Futreal Andrew P. , Gillis Nancy , Neelapu Sattva S. , Takahashi Koichi 
Published: May 2022

Abstract

To explore the role of clonal hematopoiesis (CH) in chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep sequencing on buffy coats collected during the 21 days before lymphodepleting chemotherapy from 114 large B-cell lymphoma patients treated with anti-CD19 CAR T cells. We detected CH in 42 (36.8%) pretreatment samples, most frequently in PPM1D (19/114) and TP53 (13/114) genes. Grade ≥3 immune effector cell-associated neurotoxicity syndrome (ICANS) incidence was higher in CH-positive patients than CH-negative patients (45.2% vs. 25.0%, P = 0.038). Higher toxicities with CH were primarily associated with DNMT3A, TET2, and ASXL1 genes (DTA mutations). Grade ≥3 ICANS (58.9% vs. 25%, P = 0.02) and ≥3 cytokine release syndrome (17.7% vs. 4.2%, P = 0.08) incidences were higher in DTA-positive than in CH-negative patients. The estimated 24-month cumulative incidence of therapy-related myeloid neoplasms after CAR T-cell therapy was higher in CH-positive than CH-negative patients [19% (95% CI, 5.5–38.7) vs. 4.2% (95% CI, 0.3–18.4), P = 0.028].

Significance:
Our study reveals that CH mutations, especially those associated with inflammation (DNMT3A, TET2, and ASXL1), are associated with severe-grade neurotoxicities in lymphoma patients receiving anti-CD19 CAR T-cell therapy. Further studies to investigate the mechanisms and interventions to improve toxicities in the context of CH are warranted.
See related content by Uslu and June, p. 382.
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