bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal muscle and subcutaneous fat quantity as prognostic indicators in cardiac amyloidosis
Authors: Longinow Joshua , Mirzai Saeid , Chen Po‐Hao , Hanna Mazen , Tang W.H. Wilson 
Published: February 2025

AimsDisease‐related changes in body composition are associated with worse outcomes in chronic heart failure. In cardiac amyloidosis (CA), the prognostic value of direct body composition measures is understudied.Methods and resultsWe identified 160 consecutive patients with CA (transthyretin [ATTR] or light chain [AL]) diagnosed between 2001 and 2021 who had chest computed tomography within 1 year before diagnosis. Skeletal muscle index (SMI), intermuscular adipose tissue percentage (IMAT%), and subcutaneous adipose tissue index (SATI) were quantified at the twelfth vertebral level and analysed continuously, in sex‐stratified tertiles, and with derived outcome‐based cutoffs. In a comprehensive model including IMAT% and SATI, only SMI independently predicted 10‐year mortality (hazard ratio 0.69 per standard deviation increase, 95% confidence interval 0.52–0.91, p = 0.010). In tertile analyses, low SMI was associated with 2 to 2.5 times higher 1‐year, 5‐year, and 10‐year mortality versus high SMI. Medium IMAT% and SATI showed approximately 1.9 times higher 5‐year and 10‐year mortality versus high tertiles. These associations were more pronounced in ATTR‐CA, with low SATI also predicting higher mortality. AL‐CA showed fewer significant associations. Interaction testing by CA type was not significant. Outcome‐based SMI cutoffs of 23.5 cm2/m2 (males) and 27.8 cm2/m2 (females) for 10‐year mortality were derived but need validation.ConclusionLower SMI was associated with increased mortality risk in patients with CA, particularly ATTR‐CA. The relationship between SATI and mortality was more nuanced: in the overall cohort, medium SATI was associated with higher mortality risk, while in patients with ATTR‐CA, lower SATI predicted higher mortality risk.
Characteristics, determinants, and prognostic impact of severe tricuspid regurgitation in patients with atrial functional mitral regurgitation: Insights from the REVEAL‐AFMR registry
Authors: Kaneko Tomohiro , Murata Azusa , Amano Masashi , Sato Yukio , Ohno Yohei , Obokata Masaru , Sato Kimi , Okada Taiji , Fujita Wataru , Morita Kojiro , Machino‐Ohtsuka Tomoko , Abe Yukio , Minamino Tohru , Kagiyama Nobuyuki 
Published: February 2025

AbstractAimsTricuspid regurgitation (TR) is often seen in patients with atrial functional mitral regurgitation (AFMR). The aim of this study was to investigate the characteristics, determinants, and prognostic impact of severe TR coexisting with AFMR.Methods and resultsIn 26 facilities in Japan, patients with significant AFMR defined with moderate or severe functional mitral regurgitation with dilated left atrium and preserved left ventricular function were enrolled. The primary endpoint was a composite of heart failure hospitalization and all‐cause mortality. The secondary endpoint was all‐cause mortality. In 792 patients with AFMR (mean age 77 ± 9 years, 55% female), the prevalence of severe TR was 14.9% (n = 118) overall, and 34.6% in severe AFMR. Patients with severe TR were older, mostly with atrial fibrillation, and had more severe heart failure symptoms and more advanced left atrial and right heart remodelling than those with non‐severe TR. Age >75 years, permanent atrial fibrillation, chronic obstructive pulmonary disease, and higher right atrial pressure appeared as independent determinants of severe TR. Severe TR was associated with both the primary and secondary endpoints after adjusted for covariates including the severity of AFMR (adjusted hazard ratio 1.65 [95% confidence interval 1.09–2.47], p = 0.017 and 1.80 [1.06–3.06], p = 0.029 for the primary and secondary endpoints, respectively). Atrial and ventricular functional TR accounted for 41% and 59% of significant TR. Despite more advanced right heart remodelling in ventricular TR, these groups showed similar prognosis.ConclusionsSevere TR coexisting with AFMR was common and was associated with increased event rates. Further study is warranted to establish therapeutic strategies.
Efficient Use of Renewable Solar Energy Resource for Electric Vehicles: Opportunities and Challenges
Authors: Rahim Abdul , Agarwal Shikha , Gupta Gunjan , Singh Rajesh , Malik Praveen Kumar 
Published: February 2025

ABSTRACTThis research delves into innovative solutions for integrating renewable solar energy into electric vehicle (EV) systems to mitigate limitations associated with battery storage and charging infrastructure. By leveraging advanced technologies, such as phase change materials for efficient thermal management, microgrid‐based charging systems for decentralized energy distribution, and cutting‐edge materials like aerogel composites and polymer solar cells for enhanced energy harvesting, this study addresses critical challenges in sustainable transportation. Through a holistic approach that combines energy efficiency, advanced material science, and renewable energy integration, the research provides actionable insights to enhance EV performance, extend battery life, and reduce greenhouse gas emissions. The findings hold significant implications for improving energy autonomy, enabling sustainable mobility solutions, and fostering environmental conservation in the transportation sector.
Nanotechnology‐Enabled Devices for Ocean Internet of Things
Authors: Shang Chenjing , Chen Yi , Dai Zhuhang , Yalikun Yaxiaer , Qian Lihua , Lee Pooi See , Yang Yang 
Published: February 2025

ABSTRACTThe growing utilization of the Ocean Internet of Things (Ocean IoT) has a significant impact on human society. Recent advances in nanotechnology in terms of developing unprecedented structural, mechanical, electrical, chemical, and photonic properties have led to devices that are expected to promote the sustainable growth of the emerging Ocean IoT. This review provides a system‐level analysis of nanotechnology‐enabled sensors, actuators, energy harvesting, antifouling coatings, and environmental remediation that have been developed, with a focus on their materials, structures, and manufacturing technologies, as well as their merits and drawbacks. The challenges associated with the ecotoxicity of nanotechnology‐derived pollutants in marine ecosystems are also discussed. Finally, potential future research directions are presented for this emerging field.
High‐Impedance Fault Detection in Distribution Networks Based on Support Vector Machine and Wavelet Transform Approach (Case Study: Markazi Province of Iran)
Authors: Attar Mohammad Sadegh , Miveh Mohammad Reza 
Published: February 2025

ABSTRACTHigh impedance faults (HIFs) can lead to crucial damage to the utility grid, such as the risk of fire in material assets, electricity supply interruptions, and long service restoration times. Due to their low current magnitude, conventional protective equipment, such as overcurrent relays, cannot detect these faults. Alternatively, the waveform and variation range of current in HIFs are similar to other phenomena, such as linear and nonlinear load changes and capacitor banks. This paper employs a support vector machine (SVM) classification algorithm that demonstrates reliable accuracy and discrete wavelet transform (DWT) in HIF detection. First, the data set containing measured current signals of HIFs is collected to implement this approach. Then, DWT decomposes it to extract the features of each sample in the data set. The extracted features from this part are used as input to the SVM classification algorithm. The proposed idea is initially implemented on the IEEE 34‐bus distribution test network. The proposed method achieves high capability and accuracy in detecting high‐impedance faults. The proposed method is also applied to a real power distribution network in Markazi Province of Iran, yielding satisfactory results. EMTP‐RV simulation software is used to simulate and evaluate the proposed method for power network modeling. Moreover, MATLAB software is used for feature extraction, and Python programming language in Google Colab and Spyder environment is applied to implement the SVM algorithm. The simulation results confirm the high accuracy of the suggested method. The main criteria obtained by the proposed method include accuracy, sensitivity, specificity, precision, F‐score, and Dice, which are 99.581%, 98.684%, 100%, 100%, 99.338%, and 99.338%, respectively, for the test network, and 97.94%, 93.45%, 100%, 100%, 96.614%, and 96.618%, respectively, for the real power distribution network.
Assessment of Caffeine Content in Tea and Coffee Brands Within the Palestinian Market Using HPLC Method
Authors: Hisham Waad , Nur Haneen , Sinokort Hanadi , Haslamon Duha , Khraiwesh Alaa , Qawasmeh Abdel 
Published: February 2025

ABSTRACTTea and Arabic coffee drinks are part of the daily routine for the Palestinian population due to deep cultural roots and their caffeine contents. The quality of the tea and coffee may be affected by the controlled‐long quarantine procedure followed during importation. Caffeine quantity in tea and coffee samples imported into Palestine has never been assessed. A documented HPLC method was used to determine caffeine contents in Palestinian commercially available imported brands of tea and coffee. The average caffeine content (%w/w) of tea and coffee samples was in the ranges of 0.94%–1.5% and 0.45%–0.74%, respectively. The limit of quantitation (LOQ) and the limit of detection (LOD) were found to be 1.3 and 0.5 ppm, respectively. The relative standard deviation (RSD) for repeatability was less than 5%, which is acceptable, whereas the recovery was more than 97%. The quantity of caffeine in commercially tea and coffee samples test were within the range documented in literature. This suggests that the tea and coffee quality in terms of their caffeine content has not been affected by the procedural/political issues surrounding occupied Palestinian territories. Whether other factors such as phenolic compounds and their attributed antioxidant capacity are affected is a subject of future studies.
Technological and Socio‐Demographic Factors Influencing Telemedicine Literacy in Trinidad and Tobago: A Cross‐Sectional Study Using Multidimensional Approach
Authors: Ezinne Ngozika E. , Koomson Isaac , Anyasodor Anayochukwu E. , Antwi‐Adjei Ellen K. , Bhattarai Dipesh , Armitage James , Osuagwu Uchechukwu L. 
Published: February 2025

ABSTRACTBackground and AimsThe COVID‐19 pandemic restriction impacted physical or face‐to‐face interactions, leading to an upsurge in the use of information technology (IT). This necessitated the adoption of various remote healthcare services including telehealth. This study aimed to examine the role of technological and socio‐demographic factors in enhancing telemedicine literacy.MethodsThis cross‐sectional study was conducted in Trinidad and Tobago (T&T) in 2022 involving 528 participants. The study employed the Alkire‐Foster multidimensional method to measure the telemedicine literacy of participants. The multidimensional telemedicine literacy index was constructed using nine indicators spread across three dimensions (i.e., knowledge, attitude/perception, and practice dimensions), where a threshold of 0.5 was employed to identify those with adequate knowledge to be considered literate in telemedicine. The technological component was captured using IT ability. Participants completed a 31‐item questionnaire administered electronically via iPads. A “Yes” response was coded as 1 and “No” as 0.ResultsMost respondents (62%) were aged 21–40, with 60% identifying as female. Most were Afro‐Trinidadian (54.46%), urban residents (84%), employed (80%), and earned a high income (87%). Overall, participants demonstrated a high perceived IT ability, with a mean score of 0.918 (SD = 0.27). Urban residents exhibited IT skills that were 10% superior to those of rural residents; however, this did not necessarily translate into higher telemedicine literacy. Gender differences were observed, with males reporting IT skills 3% higher than females. Notably, IT ability was a significant predictor of telemedicine literacy, particularly among females and urban residents. Additionally, individuals with postgraduate qualifications, Indo‐Trinidadians, and Christians exhibited significantly higher telemedicine literacy.ConclusionsThis study emphasizes the pivotal role of IT ability in telemedicine literacy across varied socio‐demographic groups in T&T. To promote healthcare for all, interventions targeting digital literacy are crucial to ensure equitable access and enhance the reach of telemedicine in T&T.
Evaluation of the Effects of Postsleeve Gastrectomy Exercise on Long‐Term Glucose Profile and Weight Loss Among Iranian Females: A Prospective Cohort Study From 2016 to 2020
Authors: Norooz Mohammad Tayefeh , Safavi‐Naini Seyed Amir Ahmad , Jamshidi Parnian , Sadeghi Alireza , Tabesh Mastaneh Rajabian , Abolhasani Maryam , Abbasi Maryam , Alamdari Nasser Malekpour , Berger Nathan A. 
Published: February 2025

ABSTRACTBackgroundWeight regain after surgery is linked to an increased risk of relapse for obesity‐related comorbidities, such as type 2 diabetes mellitus (T2DM). This study aims to explore how exercise after laparoscopic sleeve gastrectomy (LSG) affects glucose levels and the percentage of excess body weight loss (%EBWL).MethodsIn this study, females with non‐insulin‐dependent T2DM who underwent LSG between 2014 and 2015 were enrolled and followed at 1 and 4 years postoperatively in a prospective cohort design. Data on glucose profile, body mass index, and the quality and quantity of exercise were collected. Adequate activity was defined as engaging in more than 150 min of exercise per week. Participants were divided into two groups: the control cohort (low activity) and the exposure cohort (adequate activity). The primary outcomes were %EBWL and glycated hemoglobin (HbA1c). Statistical analysis was performed using paired t‐tests and linear regression in the R programming language.ResultsThe study comprised 246 female participants with a mean age of 46.93 ± 8.07 years, drawn from an initial cohort of 249 individuals. Significant associations were observed between %EBWL, fasting blood glucose, and HbA1c with the intensity of exercise. The active cohort exhibited superior outcomes in terms of %EBWL (78.1 ± 22.06 vs. 28.1 ± 10.9), reductions in HbA1c (−0.37% vs. −0.01%), and a decrease in body mass index (−11.6 vs. −8.46 kg/m²). The following formula was established to predict %EBWL at 48 months based on exercise levels (R2 = 0.86): %EBWL (at 48‐month) = −5 (if no exercise at all) + 1*exercise time (minutes/day) + 10*exercise frequency (session/week).ConclusionThis study highlights the essential role of postoperative exercise in facilitating long‐term weight loss and modest improvements in glucose profiles. The developed formula effectively predicts %EBWL based on the patient's exercise profile, thereby emphasizing the significance of physical activity and patient engagement in attaining sustained positive outcomes. It is recommended that patients receive guidance on maintaining an active exercise regimen.
Effectiveness of a Cannabinoids Supplement on Sleep and Mood in Adults With Subthreshold Insomnia: A Randomized Double‐Blind Placebo‐Controlled Crossover Pilot Trial
Authors: Hausenblas Heather , Hooper Stephanie , Lynch Tarah 
Published: February 2025

ABSTRACTBackground and AimsConduct a pilot randomized double‐blind placebo‐controlled crossover trial for adults with subthreshold insomnia symptoms to examine the effectiveness of a cannabinoids supplement on sleep quality and health outcomes.MethodsAdults with subthreshold insomnia symptoms (N = 20, Mage = 47.40) were randomized to either the Cannabinoids Supplement (CS) or Placebo Condition (PC) for 10 days. The CS was an oral soft gel that contained 3 mg Δ9‐tetrahydrocannabinol, 6 mg cannabinol, 10 mg cannabidiol, and 90 mg of a proprietary food‐grade terpene blend. Following a 2‐week washout, they completed the alternate condition. The following validated questionnaires were collected at baseline and following each condition: Insomnia Severity Index, Pittsburgh Sleep Quality Index, Bergen Insomnia Scale, Profile of Mood States (POMS), Perceived Stress Scale, Pain and Sleep Questionnaire. Trait Anxiety Inventory, Flinders Daytime Fatigue, and Health‐related Quality of Life Scale. Clinical trial registry number = ISRCTN 15022302.ResultsWhen compared to PC, the CS Condition had significantly improved sleep quality/efficiency, insomnia symptoms, and health‐related quality of life, p < 0.05. Nonsignificant improvements for the CS compared to the PC were found for the POMS mood subscales of tension, anger, fatigue, depression, and vigor, as well as anxiety. The Esteem subscale improved significantly from Baseline to Post for the PC. Both the CS and PC Vigor improved significantly from baseline. Anxiety improved significantly from Baseline to Post for the CS. No adverse events reported.ConclusionThis cannabinoid‐based formulation was a well‐tolerated oral supplement that may improve adults' sleep quality/efficiency and health‐related quality of life. Larger controlled trials are encouraged to examine the longer‐term effects of this supplement in a variety of populations and environments.
Association of SIRT1 rs3758391 Polymorphism With T2DM in Bangladeshi Population: Evidence From a Case‐Control Study and Meta‐Analysis
Authors: Ahmed Rezwana , Safa Mushfikur Rahman , Zahid Zahidul Islam , Chowdhury Md. Mazharul Islam , Hasan A.B.M. Kamrul , Mostaid Md. Shaki , Reza Hasan Mahmud 
Published: February 2025

ABSTRACTBackground and AimType 2 diabetes mellitus (T2DM) remains one of the major causes of morbidity and mortality worldwide, including Bangladesh. SIRT1, an NAD‐dependent deacetylase, is involved in energy homeostasis and protects β‐cells of the pancreas from oxidative stress. Single nucleotide polymorphisms (SNPs) in the SIRT1 gene have been found to be associated with T2DM in several populations, however, with conflicting results. The aim of this present case‐control study, along with the meta‐analysis, was to elucidate the association of rs3758391 polymorphism with the susceptibility to T2DM in Bangladeshi population.Methods72 T2DM patients and 90 healthy controls were enrolled in our study and polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) was employed for genotyping the SNP. Odds ratio (OR) with 95% confidence interval (95% CI) was used to represent the association of SIRT1 polymorphism with T2DM. For the meta‐analysis six studies were included and pooled odds ratio with 95% CI were calculated for six genetic models using the random effects model. Heterogeneity and publication bias was also calculated for each study.ResultsA significant association was found between rs3758391 polymorphism and increased risk of T2DM under codominant TT versus CC (OR = 3.88, 95% CI = 1.34–11.25, p = 0.012), recessive TT versus CC + CT (OR = 2.83, 95% CI = 1.12–7.09, p = 0.027) and allelic T versus C (OR = 1.67, 95% CI = 1.07–2.60, p = 0.024) genetic models. However, no significant association between rs3758391 and other biochemical and anthropometric parameters were found. Our meta‐analysis showed no statistically significant association of this polymorphism.ConclusionWe conclude that, polymorphism at rs3758391 of SIRT1 gene conferred an increased risk of T2DM in Bangladeshi population.
Incidence trends and relative survival of colorectal neuroendocrine neoplasms: A population‐based study using German cancer registry data
Authors: Möller Lennart , Szentkirályi Andras , Eisfeld Christine , Wellmann Ina , Rees Franziska , Claaßen Kevin , Oesterling Florian , Kajüter Hiltraud , Stang Andreas 
Published: February 2025

AbstractNeuroendocrine neoplasms (NENs) of the colon and rectum are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. They include well‐differentiated neuroendocrine tumors (NETs), poorly differentiated neuroendocrine carcinomas (NECs) and mixed neuroendocrine‐non‐neuroendocrine neoplasms (MiNENs). Our aim was to calculate incidence, incidence trends and relative survival for colonic and rectal NETs, NECs, and MiNENs. We analyzed data covering the entire German population recorded between 2009 and 2021, calculating age‐standardized incidence rates, annual percent changes, and the relative 5‐year survival probability for the calendar period 2017–2021. Our comprehensive analyses included 12,602 NEN cases, with 59% located in the rectum. NECs, MiNENs and tumors with colonic location showed higher stages. We observed an increase in the incidence of NETs, particularly in patients aged <55 years, and in the incidence of MiNENs, and a constant incidence of NECs. The relative five‐year survival was high for rectal NETs (95.9%, 95%‐CI 94.6; 97.1) and colonic NETs (81.4%, 95%‐CI 78.3; 84.5) and low for colonic NECs (20.5%, 95%‐CI 17.6; 23.4) and rectal NECs (19.2%, 95%‐CI 15.7; 22.6). The increase in the incidence of NETs might be partly due to colorectal cancer screening, improved diagnostics, and changes in classification of NETs. We attribute the increase in incidence of MiNENs to the recent introduction of this morphological category. Higher stages at diagnosis, a higher proportion of NECs and higher median age at diagnosis may contribute to the less favorable survival probabilities associated with colonic as opposed to rectal location.
Risk Taking and Accidents in Adventure Sports Across Males and Females
Authors: Blanch Angel , Martínez Albert 
Published: February 2025

ABSTRACTThe popularity and practice of adventure physical activities in nature (APAN) have risen substantially in the past 20 years. At the same time, the number of events leading to serious injury has increased substantially. Several factors account for the occurrence of such events, albeit individual differences in personality traits together with sex differences appear as important intervening factors. Social or evolutionary approaches might be helpful to explain the higher risk taking and accidents in males compared with females. We evaluated whether sex similarities or differences emerged when relating individual traits with accidents in adventure sports, with a sample of Spanish practitioners of adventure sports (337 males, 168 females). Males endured more accidents than females albeit scoring similarly in risk taking. There was a more robust association between age and deliberate risk taking for males than for females, and risk taking was a more robust predictor of accidents for males than for females. Further, males remained more prone than females to endure an accident when scoring high in risk taking.
CH Bond Activation Mechanism by a High‐Valent Dinuclear Copper Complex: Unraveling the Effect of a Base by a Theoretical Study
Authors: Mangel Oceane , Jamet Helene 
Published: February 2025

ABSTRACTRecently, an electrochemically monooxidized dinuclear copper(II) complex [Cu2(L)(μ‐OH)2]2+ with the dipyridylethane naphthyridine ligand (L) has been shown to activate the recalcitrant aliphatic Csp3H bond of toluene (bond dissociation free energy, BDFE = 87.0 kcal mol−1) at room temperature. The mechanistic pathway turns from stoichiometric to catalytic upon addition of a base (2,6‐lutidine), suggesting a modification of the reactive species. Herein, we report theoretical calculations to characterize the reactive species and obtain a detailed understanding of the reactivity. Since different electronic structures are possible for these high valent systems, we perform DFT calculations coupled to CCSD(T) ones using the DLPNO‐CCSD(T) scheme. Our results show that the presence of a base will impact the nature of the reactive species but also the type of mechanism involved in the CH activation.