bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-β Signaling Constrains Endothelial-to-Mesenchymal-Transition in Atherosclerosis
Authors: Dong Yunzhou , Wang Beibei , Du Mulong , Zhu Bo , Cui Kui , Chan Siu-Lung , Cowan Douglas B. , Bhattacharjee Sudarshan , Shan Dan , Wong Scott , Bischoff Joyce , Linton MacRae F. , Chen Hong 
Published: August 2022

ABSTRACTBACKGROUNDEpsin endocytic adaptor proteins are implicated in the progression of atherosclerosis; however, the underlying molecular mechanisms have not yet been fully defined. In this study, we determined how epsins enhance endothelial-to-mesenchymal transition (EndoMT) in atherosclerosis and assessed the efficacy of a therapeutic peptide in a preclinical model of this disease.METHODSUsing single cell RNA sequencing (scRNA-seq), combined with molecular, cellular, and biochemical analyses, we investigated the role of epsins in stimulating EndoMT using knock-out mouse models. The therapeutic efficacy of a synthetic peptide targeting atherosclerotic plaques was then assessed inApoe−/−mice.RESULTSScRNA-seq and lineage tracing revealed that epsins 1 and 2 promote EndoMT, and the loss of endothelial epsins inhibits EndoMT marker expression as well as transforming growth factor-beta signalingin vitroand in atherosclerotic mice, which is associated with smaller lesions inApoe−/−mouse model. Mechanistically, the loss of endothelial cell epsins results in increased fibroblast growth factor receptor-1 (FGFR1) expression that inhibits TGF-β signaling and EndoMT. Epsins directly bind ubiquitinated FGFR1 through their ubiquitin-interacting motif (UIM), which results in endocytosis and degradation of this receptor complex. Consequently, administration of a synthetic UIM–containing peptide API significantly attenuates EndoMT and progression of atherosclerosis.CONCLUSIONSWe conclude that epsins potentiate EndoMT during atherogenesis by increasing TGF-β signaling through FGFR1 internalization and degradation. Inhibition of EndoMT by reducing epsin-FGFR1 interaction with a therapeutic peptide may represent a novel treatment strategy for atherosclerosis.
Fabrication and microstructural characterization of Al-SiC based functionally graded disk
Authors: Madan Royal , Bhowmick Shubhankar 
Published: August 2022

Purpose
The purpose of this study is to investigate the performance of disks that can be increased by functionally grading the disk in the radial direction; there are several but distinct categories of literature that pertain to the fabrication of disk in the thickness direction, but to the best of the authors’ knowledge, no study has been conducted yet, in which gradient composition changes radially.

Design/methodology/approach
A powder metallurgy technique was used for the fabrication of Al-SiC-based, three-and five-layered functionally graded (FG) disk. The variation of volume fraction of reinforcement particles (SiC) in a disk changes radially. Finite element analysis has been performed to investigate stress distribution in a layered disk.

Findings
The microstructural investigation was carried out under an optical microscope and scanning electron microscopy integrated with EDS, confirming a uniform distribution of SiC in the matrix (Al). Interface microstructure indicates a successful fabrication of FG material because the transition is uniform in the graded layer without any development of crack or void at the interface. The grain size in the layers decreases with the addition of SiC particles. Additionally, the disk hardness increases as the SiC composition in the layer increases.

Practical implications
An FG disk can be used in a wide range of machinery, from power transmission assemblies to energy storage devices (e.g. flywheel, gears, rotors and disk brake).

Originality/value
The proposed powder metallurgy technique could be used in industries for the fabrication of simple to complicated geometries with FG properties.
Other customers' service failure and recovery encounters: a qualitative exploration
Authors: Gupta Niharika , Verma Harsh V. 
Published: August 2022

PurposeService failure and recovery encounters are often witnessed by other customers, but little is known about how these encounters impacts other customers. With an aim to bridge this gap, the purpose of the paper is to explore why and how service recovery directed at a focal customer impacts other customers who are present in the same service environment.Design/methodology/approachThe paper follows a qualitative research methodology. Purposive sampling was used to collect data from 30 customers through semi-structured face-to-face interviews. The data was analysed using thematic analysis.FindingsFindings of the study show that service recovery directed at a focal customer has an impact on other customers' fairness judgments, emotions, service quality perceptions and behaviour. Other customers' behavioural reactions in response to observed service recovery are driven by two different motives: self-interest and moral obligation. Observing customers' cautious behaviour and (re)purchase behaviour are found to be primarily driven by self-interest, whereas their helping behaviour, punishment behaviour and word-of-mouth behaviour are found to be driven by moral obligation.Research limitations/implicationsThis study findings contribute to theory development on “other-oriented” effects of service recovery and provides valuable insights for effective management of service failures in the shared service environment.Originality/valueThis is the first study, which qualitatively explores the “other customers” perspective of service recovery in the context of shared servicescape.
Social aspect versus service quality in trust formation toward mobile payment adoption: a case study of Indonesia
Authors: Lisana  , Handarkho Yonathan Dri 
Published: August 2022

PurposeThis research aims to investigate the significant influence of social factors based on the social impact theory against service quality factors based on uncertainty avoidance dimension in determining user perception of trust toward mobile payment (MP) usage.Design/methodology/approachThe theoretical model used was analyzed by adopting the structural equation modeling technique. Questionnaires were delivered to Indonesian customers as the target respondents using Google Forms, and finally, 659 valid responses were received.FindingsBased on the direct effect analysis, service quality had more influence on the user trust perception than the social aspect. More specifically, Perceived Security was the most influential in increasing the level of user trust followed by Perceived Usefulness and Network Externalities.Originality/valueThis research presents a comprehensive investigation that applied a different perspective of the way social and service quality aspects develop user trust toward MP usage.
Impact of MD&A sentiment on corporate investment in developing economies: Chinese evidence
Authors: Fedorova Elena , Drogovoz Pavel , Nevredinov Alexandr , Kazinina Polina , Qitan Cai 
Published: August 2022

PurposeThe goal of the study is to examine the effects of management discussion and analysis (MD&A) sentiment in public companies' annual reports on corporate investment incentives in developing economies.Design/methodology/approachThe authors use sentiment analysis of MD&A texts based on Loughran and McDonald (2011) and combination of panel data regression, logit model and random forest. The text data consists of 3,511 annual reports of Chinese listed companies for the period from 2010 to 2019.FindingsThis paper provides empirical evidence of signaling theory that sentiment of annual reports and MD&A influences corporate decisions on both M&A and internal investments. The authors found that comparing to annual reports MD&A sentiment has more stable and significant explanatory and predictive power.Practical implicationsThis paper confirms the importance of MD&A sentiment for corporate investment decision taking and provides practical techniques for analysts and researchers to study corporate investment incentives from the point of view of signaling theory.Originality/valueThe study aims to expand the domains of signaling theory and corporate investment valuation by including a broader range of data on companies' M&A and internal investments in developing economies. To explore the impact of MD&A sentiment on corporate investment, a state-of-the-art set of text mining and machine learning techniques is used. The authors' results confirm that MD&A has signaling effect and can get a positive market response. Furthermore, this study enhances the empirical evidence of overconfidence theory, i.e. optimistic management whose MD&A tend to positive overestimates the management's investments decision and also underestimate the potential risk to the firm.
Managerial Coase theorem: evidence from China
Authors: Gao Shaohui , He Yiming 
Published: August 2022

Purpose
This paper aims to take a step in this direction and use the high dimensional fixed effects and quantile regression discontinuity design to test the managerial Coase theorem, which provides an institutional perspective for us to gauge the impact of private property rights on firm performance and the effect of management costs on intermediate inputs.

Design/methodology/approach
This study first uses high dimensional regression discontinuity designs to examine the impact of privatization on firm performance in China between 1998 and 2013.

Findings
Results indicate that privatization effects increase average outputs of the firm by around 10% given lower management costs, and management costs increase intermediate inputs by more than 50% points. Using data from annual surveys to test managerial Coase theorem, the authors show that management costs negatively affect the marginal effect of privatization on the average outputs of the firm. The positive impact on the investment in intermediate goods and services is larger in magnitude under higher management costs.

Originality/value
The authors develop the managerial Coase theorem. Today, given lower management costs, private property rights provide an incentive structure for a firm to maximize the value of the assets and expand the boundaries.
Supply chain network structure and firm's R&D investments: empirical evidence from Chinese manufacturing firms
Authors: Huang Heshu , Zhang Jiping , Yan Ji , Gong Yu , Wang Liukai 
Published: August 2022

PurposeThe purpose of this research is to investigate the R&D investment (RDI) of manufacturing firms from the perspective of supply chain network, especially the effect of firms' supply chain network structures (network power and network cohesion) on its RDI, and further to explore the contingency conditions of this effect within the context of Chinese manufacturing supply chains.Design/methodology/approachThe authors collect a large sample of Chinese manufacturing firms over the period 2014–2019 and construct a large-scale supply chain network, and finally obtain 2,390 firms from 20,483 observations. Ordinary least squares regression was adopted to analyse how supply chain network structures affect RDI in manufacturing firms.FindingsIt is surprising that firm's supply chain network structures have a negative effect on RDI. In addition, knowledge and technology intensity (KTI) positively moderate the relationship between network cohesion and RDI.Originality/valueThis study contributes to the innovation stream from the perspectives of supply chain network, and provides the empirical findings that the negative role of a firm's supply chain network structure on its RDI for the first time. The rationale for these negative effects is straightforward according to the social capital theory that manufacturing firms with a high level of social capital that are possibly to accept established patterns of thinking and behaviour, causing them to decrease the enthusiasm of RDI.
Disruptive human resource management technologies: a systematic literature review
Authors: Priyashantha K.G. , De Alwis A. Chamaru , Welmilla Indumathi 
Published: August 2022

PurposeThe disruptive human resource management (HRM) technologies are now considered a significant facilitator to change and benefit the entire HRM landscape. This view needs to be further verified by reviewing the knowledge on the subject in the empirical research landscape. Thus, the study's objectives were to find (1) the current knowledge and (2) the areas where empirical research is lacking in disruptive HRM technologies.Design/methodology/approachThe article is a literature review that was followed by the systematic literature review and the preferred reporting items for systematic reviews and meta-analyses (PRISMA). The review considered 45 articles published during the 2008–2021 period extracted from the Scopus database, and bibliometric analysis was performed to achieve the research objectives.FindingsThe results found that scholarly attention has been given to electronic HRM (E-HRM) rather than the disruptive HRM technologies. The areas investigated include the determinants of intention, adoptions and use of E-HRM and the outcomes of E-HRM adoptions and use. These outcomes can be further divided into general outcomes and HRM outcomes.Research limitations/implicationsThe findings reveal gaps in E-HRM research and disruptive HRM technologies remain untapped in the empirical research landscape. Hence, the study findings provide some implications for future research and applications.Originality/valueThe study found empirically proven determinants of E-HRM intention, adoptions and use and E-HRM adoptions and use outcomes. These were found in the studies conducted during the 2008–2021 period.
An empirical survey on prevalence and demographic differences in academic dishonesty among undergraduates from four public universities in China
Authors: Liu Xinjuan , Alias Noryati 
Published: August 2022

PurposeThis empirical survey is conducted to investigate the prevalence rate of academic dishonesty (AD) in examinations and assignments among undergraduates. The study compared the difference in admitted behaviours of academic dishonesty between male and female students comprising second-year, third-year and fourth-year students from the discipline of business, engineering, information technology (IT) and education.Design/methodology/approachA cross-sectional study was utilized in this study and collected data via the online questionnaire. A total of 1,624 respondents participated from four public universities of four provinces in China Mainland.FindingsThe findings showed that the proportion of respondents from China participating in AD is between 15.4 and 51.7%. The findings showed that more than two-thirds of the respondents stated involved dishonesty in examinations and assignments at least once during the previous academic year. In addition, male and female undergraduates in second-year, third-year and fourth-year showed statistically significant differences in dishonest behaviours. Specifically, the male/senior students were more involved in dishonest behaviours than the females/sophomores.Originality/valueUnlike previous studies, this study found that discipline in the Chinese context was not a significant demographic predictor of dishonesty. Although not significantly different, the respondents majoring in business reported a high engagement rate of dishonesty, followed by engineering and information technology undergraduates, but education undergraduates revealed the lowest engagement rate of dishonesty. The target integrity education should be imparted among male and senior students.
Submitting tentative solutions for platform feedback in crowdsourcing contests: breaking network closure with boundary spanning for team performance
Authors: Javadi Khasraghi Hanieh , Wang Xuan , Sun Jun , Javadi Khasraghi Bahar 
Published: August 2022

PurposeTo obtain optimal deliverables, more and more crowdsourcing platforms allow contest teams to submit tentative solutions and update scores/rankings on public leaderboards. Such feedback-seeking behavior for progress benchmarking pertains to the team representation activity of boundary spanning. The literature on virtual team performance primarily focuses on team characteristics, among which network closure is generally considered a positive factor. This study further examines how boundary spanning helps mitigate the negative impact of network closure.Design/methodology/approachThis study collected data of 9,793 teams in 246 contests from Kaggle.com. Negative binomial regression modeling and linear regression modeling are employed to investigate the relationships among network closure, boundary spanning and team performance in crowdsourcing contests.FindingsWhereas network closure turns out to be a negative asset for virtual teams to seek platform feedback, boundary spanning mitigates its impact on team performance. On top of such a partial mediation, boundary spanning experience and previous contest performance serve as potential moderators.Practical implicationsThe findings offer helpful implications for researchers and practitioners on how to break network closure and encourage boundary spanning with the establishment of facilitating structures in crowdsourcing contests.Originality/valueThe study advances the understanding of theoretical relationships among network closure, boundary spanning and team performance in crowdsourcing contests.
Enhancing the analysis of online product reviews to support product improvement: integrating text mining with quality function deployment
Authors: Asadabadi Mehdi Rajabi , Saberi Morteza , Sadghiani Nima Salehi , Zwikael Ofer , Chang Elizabeth 
Published: August 2022

PurposeThe purpose of this paper is to develop an effective approach to support and guide production improvement processes utilising online product reviews.Design/methodology/approachThis paper combines two methods: (1) natural language processing (NLP) to support advanced text mining to increase the accuracy of information extracted from product reviews and (2) quality function deployment (QFD) to utilise the extracted information to guide the product improvement process.FindingsThe paper proposes an approach to automate the process of obtaining voice of the customer (VOC) by performing text mining on available online product reviews while considering key factors such as the time of review and review usefulness. The paper enhances quality management processes in organisations and advances the literature on customer-oriented product improvement processes.Originality/valueOnline product reviews are a valuable source of information for companies to capture the true VOC. VOC is then commonly used by companies as the main input for QFD to enhance quality management and product improvement. However, this process requires considerable time, during which VOC may change, which may negatively impact the output of QFD. This paper addresses this challenge by providing an improved approach.
Education and environmental sustainability: culture matters
Authors: Komatsu Hikaru , Silova Iveta , Rappleye Jeremy 
Published: August 2022

PurposeHumans remain unsuccessful in their attempts to achieve environmental sustainability, despite decades of scientific awareness and political efforts toward that end. This paper suggests a fresh conceptualization, one that focuses on education, offers a fuller explanation for our lack of success and calls attention to alternatives.Design/methodology/approachThe authors first critically review mainstream approaches that have been used to achieve environmental sustainability, then introduce an alternative that the authors call the cultural approach. The authors finally discuss how educational research should be re-articulated based on the cultural approach.FindingsThe authors identified three mainstream approaches – the technological, cognitive approach and behaviorist – all of which function to reproduce modern mainstream culture. In contrast, the cultural approach assumes modern mainstream culture as the root cause of environmental unsustainability and aims to rearticulate it. To elaborate a cultural approach, the authors recommend education scholars to (1) bring attention to the role of culture in sustainability and (2) identify education practices that are potentially useful for enacting a cultural shift, primarily developing richer synergies between qualitative and quantitative research.Originality/valueUnlike many previous studies in the field of education, the authors’ account highlights how current mainstream approaches used for current global education policymaking often merely reproduces modern mainstream culture and accelerates the environmental crisis. It thus proposes to redirect educational research for a cultural shift, one that allows human society to move beyond the comforting rhetoric of sustainability and face the survivability imperative.
Factors affecting e-government adoption in the UAE public sector organisations: the knowledge management perspective
Authors: Al Sayegh Ahmed Juma , Ahmad Syed Zamberi , AlFaqeeh Khadeeja Mohsen , Singh Sanjay Kumar 
Published: August 2022

PurposeThis study aims to investigate factors that influence e-government adoption among public sector departments with the view to determine how such factors may be used to better facilitate e-government adoption across United Arab Emirates (UAE) public sectors. The use of e-government is advocated for the central government in the UAE.Design/methodology/approachUsing random sampling, a total of 172 participants from ten departments and organisations in Dubai and Sharjah completed the online survey for this pilot study.FindingsThe authors found that performance expectancy and facilitating conditions have positive effects on e-government adoption. Furthermore, this study revealed the factors that encourage more e-government adoption between government organisations in the UAE. This study reveals three facilitating conditions may encourage e-government adoption in UAE public sector organisations when short- and long-term performances have positive effects on e-government usage.Practical implicationsThis study provides middle managers clarity on factors that would influence government-to-government (G2G) uptake in more government organisations across the country. For uniformity and consistency, middle managers are now better informed as a result of this study to determine how best to use the six factors to motivate subordinates for more effective G2G.Originality/valueThe scope and results of this study is a contribution to e-government studies because it identifies the factors that positively influence G2G adoption. This scope exceeds the studies by Chanet al.(2021) and Habibet al.(2020) which focuses on the use of e-government for citizens or the public. This study focuses on the use of e-government within the government and between government departments.