bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedicine practice guidelines in India: Global implications in the wake of the COVID‐19 pandemic
Authors: Venkatesh U. , Aravind Gandhi P. , Velmurugan Anbu Ananthan 
Published: February 2022

AbstractTelemedicine is the delivery of healthcare services from a distance, by use of information and communication technology. There have been no statutory regulations or official guidelines in India specific for telemedicine practice and allied matters so far. For the first time, the government of India released telemedicine practice guidelines for Registered Medical Practitioners on March 25, 2020, amid the COVID‐19 outbreak. This review would initiate the discussion on the features of the guidelines, their limitations, and their significance in times of the COVID‐19 pandemic. The guidelines are with a restricted scope for providing medical consultation to patients, excluding other aspects of telemedicine such as research and evaluation and the continuing education of healthcare workers. The guidelines have elaborated on the eligibility for practicing Telemedicine in India, the modes and types of teleconsultations, delved into the doctor‐patient relationship, consent, and management protocols, and touched upon the data security and privacy aspects of Teleconsultation. After releasing the guidelines, the telescreening of the public for COVID‐19 symptoms is being advocated by the government of India. COVID‐19 National Teleconsultation Centre (CoNTeC) has been initiated, which connects the doctors across India to All India Institute of Medical Sciences (AIIMS) in real‐time for accessing expert guidance on the treatment of the COVID‐19 patients.
Understanding the gap between policy and facts: The Italian experience on federal decoupling in the implementation of breast units
Authors: Gabutti Irene , Barneschi Chiara 
Published: February 2022

AbstractDecoupling in the health‐care sector is a highly problematic phenomenon that easily leads to dramatic failures in strategy implementation. Although decoupling is addressed frequently at the organizational level, there exists extremely poor evidence of its presence at the federal/regional level. This study provides an investigation on the implementation of Italy's directive on the re‐organization of regional health‐care systems' networks based on breast units, with the intent of detecting different levels of compliance across regions and possible decoupling phenomena. Nonparametric tests are carried out to assess the gaps between formal and concrete compliance to the national directive across regions. Results suggest that decoupling occurs at the regional level, but formal compliance positively affects concrete compliance in the long term. Implications for policymakers concern their awareness of possible discrepancies between formal compliance to their directives and concrete changes in the way health‐care services are managed, as well as a strategic understanding of how these are doomed to be mitigated in the long run. Such awareness should affect the ability of policymakers to adapt and interpret performance measurement systems accordingly.
Ewen D. Cameron: Wechselwirkungen zwischen einem forschenden Psychiater und seinen professionellen wie auch gesellschaftlichen Kontexten
Authors: Helmchen Hanfried 
Published: February 2022

ZusammenfassungDer Psychiater Ewen Cameron hat bereits in den 1930er Jahren organisatorische Grundlagen für die sozialpsychiatrische Reform der psychiatrischen „Anstalt“ gelegt, das open-door-System eingeführt und 1946 die weltweit erste psychiatrische Tagesklinik gegründet. Ebenso hat er mit dem „psychic driving“ eine „automatisierte Psychotherapie“ entwickelt sowie die somatischen Behandlungsverfahren seiner Zeit (wissenschaftlicher Kontext) zu einer neuen Therapieform gebündelt, dem „depatterning“. Sein Bild in der Öffentlichkeit wurde zunächst durch seine charismatische und mit bedeutenden Ehrungen anerkannte Persönlichkeit geprägt, u.a. wurde Cameron 1961 Gründungspräsident des Weltverbandes für Psychiatrie (WPA). Als 1977 bekannt wurde, dass eines seiner Forschungsprojekte von der CIA verdeckt mitfinanziert worden war, wurde er zum Inbegriff des brainwashing-Experten stilisiert. Die in die gesellschaftliche Atmosphäre des kalten Krieges mit ihren Verschwörungsvermutungen eingebettete öffentliche Beschäftigung mit der „Gehirnwäsche“ und den Gedankenkontrolltechniken der CIA (gesellschaftlicher Kontext) veränderte das posthume Bild von Ewen Cameron grundlegend. Im kritischen Rückblick hat er seine Forschung in einem klinischen Kontext realisieren können, das sowohl sein Forschungskonzept tolerierte und offenbar höher als das Leiden des einzelnen Kranken bewertete, als auch die klaren ethischen Regeln des Jahres 1948 (Nürnberger Kodex, Genfer Deklaration des Weltärztebundes wie auch der UN-Deklaration der Allgemeinen Menschenrechte) noch nicht internalisiert hatte. Auch mit seinen sozialtechnischen Phantasien lief Cameron Gefahr, die sozialpsychiatrische Versorgung psychisch Kranker zu verlassen und in eine totalitäre Ideologie abzugleiten.
Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array
Authors: Sun Rujian , Sun Bincheng , Tian Yu , Su Shanshan , Zhang Yong , Zhang Wanhai , Wang Jingshun , Yu Ping , Guo Bingfu , Li Huihui , Li Yanfei , Gao Huawei , Gu Yongzhe , Yu Lili , Ma Yansong , Su Erhu , Li Qiang , Hu Xingguo , Zhang Qi , Guo Rongqi , Chai Shen , Feng Lei , Wang Jun , Hong Huilong , Xu Jiangyuan , Yao Xindong , Wen Jing , Liu Jiqiang , Li Yinghui , Qiu Lijuan 
Published: February 2022

AbstractKey messageWe developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding.AbstractMicroarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.
Comparison of different approaches to describe the thermotropic volume phase transition of smart microgels
Authors: Friesen Simon , Hannappel Yvonne , Kakorin Sergej , Hellweg Thomas 
Published: February 2022

AbstractThe description of gel swelling by Flory and Rehner using the original Flory–Huggins interaction parameter for the polymer–solvent interaction cannot be applied to most smart microgels. Here, we compare descriptions of the swelling curves of such microgels using series expansions of the Flory–Huggins parameter $$\chi$$
χ
with the results of Hill-like equation for $$\chi$$
χ
. We study N-isopropyl-acrylamide particles at different concentrations of the cross-linker N,N-methylenebisacrylamide. The hydrodynamic radius $$R_{\mathrm {H}}$$

R
H

of the microgel particles is determined using photon correlation spectroscopy. The fits with the series expansion of $$\chi$$
χ
nicely follow the experimental data. However, already with the first-order series expansion, the computed $$\Theta$$
Θ
temperatures are not physically reasonable. Moreover, the physical meaning of the parameters of the series expansion is not clear. The Hill-like equation, which we recently introduced, yields a good description of all measured microgel swelling curves and provides physically meaningful parameters. For instance, the Hill parameter $$\nu$$
ν
corresponds to the number of water molecules per network chain cooperatively leaving the chain at the volume phase transition.
Graphical abstract
Different approaches to model the Flory-Huggins interaction parameter are explored and compared with respect to the quality of the fit of microgel swelling curves.
Chiral pyridine oxazoline and 1,2,4-triazine oxazoline ligands incorporating electron-withdrawing substituents and their application in the Cu-catalyzed enantioselective nitroaldol reaction
Authors: Wolińska Ewa , Rozbicki Przemysław , Branowska Danuta 
Published: February 2022

AbstractEight pyridine-containing and four 1,2,4-triazine-containing chiral oxazoline ligands incorporating electron-withdrawing substituents have been synthesized by two-step route including Buchwald–Hartwig amination. Enantio-inducing activity of the ligands has been assessed in the copper-catalyzed asymmetric nitroaldol reactions and the influence of the electron-withdrawing substituents on the ligands' activity has been investigated.Graphical abstract
Desulfovulcanus ferrireducens gen. nov., sp. nov., a thermophilic autotrophic iron and sulfate-reducing bacterium from subseafloor basalt that grows on akaganéite and lepidocrocite minerals
Authors: Kashyap Srishti , Musa Masroque , Neat Kaylee A. , Leopo Deborah A. , Holden James F. 
Published: February 2022

AbstractA deep-sea thermophilic bacterium, strain Ax17T, was isolated from 25 °C hydrothermal fluid at Axial Seamount. It was obligately anaerobic and autotrophic, oxidized molecular hydrogen and formate, and reduced synthetic nanophase Fe(III) (oxyhydr)oxide minerals, sulfate, sulfite, thiosulfate, and elemental sulfur for growth. It produced up to 20 mM Fe2+ when grown on ferrihydrite but < 5 mM Fe2+ when grown on akaganéite, lepidocrocite, hematite, and goethite. It was a straight to curved rod that grew at temperatures ranging from 35 to 70 °C (optimum 65 °C) and a minimum doubling time of 7.1 h, in the presence of 1.5–6% NaCl (optimum 3%) and pH 5–9 (optimum 8.0). Phylogenetic analysis based on 16S rRNA gene sequences indicated that the strain was 90–92% identical to other genera of the family Desulfonauticaceae in the phylum Pseudomonadota. The genome of Ax17T was sequenced, which yielded 2,585,834 bp and contained 2407 protein-coding sequences. Based on overall genome relatedness index analyses and its unique phenotypic characteristics, strain Ax17T is suggested to represent a novel genus and species, for which the name Desulfovulcanus ferrireducens is proposed. The type strain is Ax17T (= DSM 111878T = ATCC TSD-233T).
Right atrial and ventricular strain detects subclinical changes in right ventricular function in precapillary pulmonary hypertension
Authors: Vos J. L. , Leiner T. , van Dijk A. P. J. , van der Zwaan H. B. , Sieswerda G. Tj. , Snijder R. J. , Post M. C. , Vonk M. C. , van Leuven S. , Vart P. , Snoeren M. , Hirsch A. , El Messaoudi S. , Nijveldt R. , Driessen M. M. P. 
Published: February 2022

AbstractRight ventricular (RV) ejection fraction (EF) by cardiac magnetic resonance (CMR) correlates to outcome in precapillary pulmonary hypertension (pPH) patients, but is insensitive to early changes. Strain might provide incremental information. In this study, we compare right atrial (RA) and RV strain in pPH patients to healthy controls, and evaluate the prognostic value of strain in pPH. In this cross-sectional study, 45 pPH patients and 20 healthy controls underwent CMR, and feature-tracking derived RA and RV strain were evaluated. pPH patients had impaired RA reservoir and conduit strain, and RV longitudinal strain (LS), compared to healthy controls. In pPH patients with preserved RVEF (≥ 50%, n = 18), RA reservoir (35% ± 9 vs. 41% ± 6, p = 0.02) and conduit strain (16% ± 8 vs. 23% ± 5, p = 0.004), and RV–LS (−25% ± 4 vs. −31% ± 4, p < 0.001) remained impaired, compared to healthy controls. The association of strain with the primary endpoint (combination of all-cause death, lung transplantation, and heart failure hospitalization) was evaluated using a multivariable Cox regression model. RV–LS (HR 1.18, 95%–CI 1.04–1.34, p = 0.01) and RA strain (reservoir: HR 0.87, 95%–CI 0.80–0.94, p = 0.001; conduit: HR 0.85, 95%–CI 0.75–0.97, p = 0.02, booster: HR 0.81, 95%-CI 0.71–0.92, p = 0.001) were independent predictors of outcome, beyond clinical and imaging features. In conclusion, pPH patients have impaired RA strain and RV–LS, even when RVEF is preserved. In addition, RA strain and RV–LS were independent predictors of adverse prognosis. These results emphasize the incremental value of RA and RV strain analyses, to detect alterations in RV function, even before RVEF declines.
Markerless gait estimation and tracking for postural assessment
Authors: Tay Chuan Zhi , Lim King Hann , Phang Jonathan Then Sien 
Published: February 2022

AbstractPostural assessment is crucial in the sports screening system to reduce the risk of severe injury. The capture of the athlete’s posture using computer vision attracts huge attention in the sports community due to its markerless motion capture and less interference in the physical training. In this paper, a novel markerless gait estimation and tracking algorithm is proposed to locate human key-points in spatial-temporal sequences for gait analysis. First, human pose estimation using OpenPose network to detect 14 core key-points from the human body. The ratio of body joints is normalized with neck-to-pelvis distance to obtain camera invariant key-points. These key-points are subsequently used to generate a spatial-temporal sequences and it is fed into Long-Short-Term-Memory network for gait recognition. An indexed person is tracked for quick local pose estimation and postural analysis. This proposed algorithm can automate the capture of human joints for postural assessment to analyze the human motion. The proposed system is implemented on Intel Up Squared Board and it can achieve up to 9 frames-per-second with 95% accuracy of gait recognition.
What Shapes Satisfaction with Democracy? Interests, Morals, and the German East–West Divide
Authors: Welsch Heinz 
Published: February 2022

AbstractThirty years after reunification, East and West Germany are still characterized by a considerable difference in satisfaction with democracy (SWD). This paper proposes and tests a model which assumes SWD to be shaped by the interests (economic and cultural) and moral values individuals demand to see fostered by the democratic system. Empirical application of the model reveals substantial differences between the East and West German SWD function in that the satisfaction of economic interests is much more important in the East than the West whereas the opposite applies to moral concerns. Demands on redistribution and immigration policies—conceptualized asproximatedrivers of SWD—also shape SWD differently in the East and the West, in addition to being shaped by interests and morals in different ways. East–West differences in therelationshipbetween economic demands and SWD are more important than differences in thelevelsof demand.
Dams in South Europe: socio-environmental approach and eDNA-metabarcoding to study dam acceptance and ecosystem health
Authors: Fernandez Sara , Arboleya Elena , Dopico Eduardo , Garcia-Vazquez Eva 
Published: February 2022

AbstractUnder current climate warming, dams and reservoirs are main options to ensure water supply in dry regions. However, the presence of these infrastructures encompasses impacts on ecosystem due to the alteration of connectivity and river habitat. We expect that as a result of the relation between water supply as a resource and the population will depend on their use or demand, so the benefits of dams compensate their negative impacts in regions with droughts while not having the same perception in zones where water supply is not a problem, so the public acceptance of dams is expected to change depending on the area. Here, we have employed a multidisciplinary approach to study dam acceptance and also measure ecosystem health in two dammed areas, Guadalhorce and Nalón rivers, Mediterranean dry south and Atlantic humid north of Spain, respectively. The methodology employed has included the use of Environmental DNA for phytoplankton inventory and surveys to stakeholders and ordinary citizens to measure dam’s acceptance. Worse bioindicators of water quality associated to dams were found in Guadalhorce than in Nalon River. However, stakeholders valued more the ecosystem services provided by Guadalhorce dams, especially of cultural nature, than those provided by Nalón dams. Most citizens consulted (N = 319 and 300 in Guadalhorce and Nalón regions) were favourable to the presence of dams and reservoirs. They would also increase their annual taxes to restore river connectivity, especially in Guadalhorce River, while dam demolition was the least supported. The generally positive views would help to identify actions for improvement of dammed rivers highlighting the importance of restoring river connectivity without dam demolition for local river users.
Genetic medicine is accelerating in Japan
Authors: Hayashi Saori , Kubo Makoto , Kaneshiro Kazuhisa , Kai Masaya , Yamada Mai , Morisaki Takafumi , Takao Yuka , Shimazaki Akiko , Shikada Sawako , Nakamura Masafumi 
Published: February 2022

Abstract
Background
In 2018, BRACAnalysis® was covered by medical insurance in Japan as a companion diagnostic test for the poly ADP-ribose polymerase inhibitor olaparib. In April 2020, eligibility for BRCA1/2 genetic testing was expanded to the diagnosis of hereditary breast and ovarian cancer syndrome, and medical management including prophylactic surgery and surveillance were covered by public insurance for BRCA1/2 mutation carriers who developed breast or ovarian cancer. The amount of BRCA1/2 genetic testing has been increasing recently, but the number of subjects and the impact of testing for patients’ outcomes remain unclear.

Patients and methods
This study explored the potential number of patients who will be eligible for new insurance coverage for BRCA1/2 genetic testing. We analyzed 868 patients from 938 surgeries between January 2014 and September 2020 from our database.

Results
Overall, 372 patients (43%) were eligible for new insurance coverage for BRCA1/2 genetic testing. The most common category was family history of breast or ovarian cancer within third-degree relatives. We found that 202 patients (23%) had family history of breast or ovarian cancer. In addition, the progression-free survival was significantly lower in triple-negative breast cancer patients aged 60 years or younger compared with the other patients (P = 0.0005).

Conclusion
The genetic medicine for primary breast cancer patients with BRCA1/2 germline mutation is accelerating rapidly in Japan. Therefore, establishing a system for the genetic medicine would be urgent.
An Optimal Thirty-Second-Order Iterative Method for Solving Nonlinear Equations and a Conjecture
Authors: Varona Juan Luis 
Published: February 2022

AbstractMany multipoint iterative methods without memory for solving non-linear equations in one variable are found in the literature. In particular, there are methods that provide fourth-order, eighth-order or sixteenth-order convergence using only, respectively, three, four or five function evaluations per iteration step, thus supporting the Kung-Traub conjecture on the optimal order of convergence. This paper shows how to find optimal high order root-finding iterative methods by means of a general scheme based in weight functions. In particular, we explicitly give an optimal thirty-second-order iterative method; as long as we know, an iterative method with that order of convergence has not been described before. Finally, we give a conjecture about optimal order multipoint iterative methods with weights.
Wind tunnel experiments of interstage segments used for aerodynamic control of retro-propulsion assisted landing vehicles
Authors: Marwege Ansgar , Hantz Christian , Kirchheck Daniel , Klevanski Josef , Gülhan Ali , Charbonnier Dominique , Vos Jan 
Published: February 2022

AbstractIn the RETALT (RETro propulsion Assisted Landing Technologies) project vertical landing launcher configurations are investigated. In the aerodynamic phase of retro propulsion assisted descent and landing, the main devices for control and trim of the vehicle are the aerodynamic control surfaces. In this paper, experimental data of a novel concept where the interstage is divided in four segments which are used as aerodynamic control surface during the aerodynamic descent of the first stage is presented. The results are compared to theoretical results obtained using a simplified modelling of supersonic and hypersonic flow fields. The interstage segments show to be very effective in creating drag for aerodynamic deceleration in the atmosphere. A large deflection of the interstage segments can lead to largely unsteady flows. The deflection of only one interstage segment does not yield statically stable configurations.
CURIE: Towards an Ontology and Enterprise Architecture of a CRM Conceptual Model
Authors: Fernández-Cejas Miguel , Pérez-González Carlos J. , Roda-García José L. , Colebrook Marcos 
Published: February 2022

AbstractCompanies face the challenge of managing customer relationships (CRM) in a context marked by a drastic digital transformation and unbridled evolution of consumer behavior, exacerbated by the COVID-19 pandemic. The customer is more demanding, has access to the global market and interacts with companies through multiple digital channels, such as email, social networks, mobile apps or instant messaging. In this situation, the success of a CRM implementation highly depends on information technology and the applications used. To harmonize this new business context with the development of information systems (IS), a suitable CRM ontology and enterprise architecture (EA) is needed. While an ontology-based conceptual model provides a unifying framework, aids sharing and reusing knowledge, and facilitates communication within a domain, an EA-based model unequivocally describes, analyzes, and visualizes how an organization should operate from the perspective of business, application, and technology. The purpose of the paper is the proposal of CURIE-O, a CRM OntoUML UFO-based ontology, together with CURIE-EA, a CRM ArchiMate-based EA to serve business managers and IS specialists an updated unifying framework of reference in the CRM domain as well as a highly efficient tool to support application development and maintenance in this changing and increasingly digital context. Modeling has proven to be an essential element to achieve high-performance information systems. In order to apply the ontology and the EA proposed here, the authors developed a CRM task management application prototype that was implemented as a case study in a consulting company. The methodology followed was design science research (DSR), in order to design and validate the artifacts. Within the DSR framework, other complementary research methods have been used, in particular literature research, interviews and focus groups carried out with several hotel chains in Tenerife (Canary Islands). The main existing CRM models in the scientific literature have also been analyzed together with the leading CRM market solutions.