bluuebunny/crossref_metadata_2025_split huggingface dataset:
541-P: Patterns of Physical Activity and Cardiometabolic Risk in Hispanic/Latino Adults with or Vulnerable to Type 2 Diabetes
Authors: BEVIER WENDY C. , LAMUNION SAMUEL , ROACH MEGAN , GLANTZ NAMINO M. , LAREZ ARIANNA , CASTORINO KRISTIN N. , CHEN KONG Y. , KERR DAVID 
Published: May 2022

While physical activity (PA) improves physical health, and wearable accelerometers clarify PA behavior, patterns of PA and cardiometabolic risk have not been well studied in ethnic minorities. In the Mil Familias observational cohort study of Hispanic/Latino adults with or at risk for type 2 diabetes (T2D) , PA was measured in 118 women and 59 men (age 56.9±10.6 years, mean±SD, HbA1c 7.1 [6.3, 9.2] %, median [IQR]) ; 150 had T2D (duration 12.2±8.2 years) . An ActiGraph wGT3X-BT was worn on the right hip 24 hours/day for 7 consecutive days (mean 4.5±1.8 days) with ≥hours waking wear time as a valid day. We found that study participants in the low HbA1c (&lt;7.0%) had significantly less waking sedentary minutes (SED) per day than those with high (≥7.0%) HbA1c (see table) . For men, there were significant differences for time standing and sitting, levels of moderate to vigorous physical activity (MVPA) , and LDL cholesterol. In women with diabetes (n=103) , individual fasting HDL (50.7±11.7 mg/dL) was positively correlated with light physical activity minutes (266.0±66.8, r=0.3, p&lt;0.05) . Also, sitting minutes (328±83.2) and standing minutes (352±97.4) correlated with waist circumference (100±12.9 cm) , r=0.2 & r=-0.2, p≤0.respectively. In these Hispanic/Latino adults, PA (from work and/or exercise) and SED time appear to have important cardiometabolic health implications.

Disclosure
W.C.Bevier: Research Support; Abbott Diabetes. S.Lamunion: None. M.Roach: None. N.M.Glantz: Research Support; Abbott. A.Larez: Research Support; Abbott. K.N.Castorino: Consultant; Lilly Diabetes, Research Support; Abbott Diabetes, Dexcom, Inc., Drawbridge Health, Inc., Eyenuk, Inc., Laxmi Therapeutic Devices, Medtronic, National Institute of Diabetes and Digestive and Kidney Diseases, Novo Nordisk, Speaker's Bureau; Dexcom, Inc. K.Y.Chen: None. D.Kerr: Advisory Panel; Abbott Diabetes, Novo Nordisk A/S, Sanofi, Consultant; Evidation Health, Research Support; Novo Nordisk A/S, Stock/Shareholder; Glooko, Inc., Hi.Health.
557-P: Effect of Monocarbonyl Curcumin Analogues C66 and B2BrBC on Pancreatic Expression of Genes Related to Insulin Signaling Pathway and Oxidative Stress in Streptozotocin-Induced Diabetes
Authors: STOJCHEVSKI RADOSLAV , ANGELOVSKI MARIJA , VELICHKOVIKJ SARA , HADZI-PETRUSHEV NIKOLA , MLADENOV MITKO , BOGDANOV JANE B. , PORETSKY LEONID , AVTANSKI DIMITER 
Published: May 2022

Curcumin has well documented beneficial effects against diabetes but its poor bioavailability limits its use. Here, we investigated the effects of two monocarbonyl curcumin analogues - (2E,6E) -2,6-bis[ (2-trifluoromethyl) benzylidene]cyclohexanone (C66) and (2E,6E) -2,6-bis (2-bromobenzylidene) cyclohexanone) (B2BrBC) - on the expression of genes involved in insulin signaling and oxidative stress in pancreas samples from streptozotocin (STZ) -induced diabetic rats. Animals were divided into two experiments: (Experiment 1) STZ injection (60 mg/kg) followed by 30 days treatment with C66 or B2BrBC (both 50 µmol/kg, daily) or (Experiment 2) single-dose treated with C66 or B2BrBC (125 µmol/kg) , 6 hours before STZ injection, and sacrifice after 72 hours. Quantitative RT-PCR analysis was used to assess the expression of: insulin (Ins1) , insulin receptor substrate 2 (Irs2) , Slc2a2 solute carrier family 2 member 2 (Slc2a2) (s. Glut2) , mitogen-activated protein kinase 14 (Mapk14) , protein kinase AMP-activated catalytic subunit alpha 1 (Prkaa1) , peroxisome proliferator-activator receptor gamma (Pparg) , BCL2 apoptosis regulator (Bcl2) , BCL2-associated X apoptosis regulator (Bax) , and NF-κB inhibitor alpha (Nfkbia) . Results demonstrated that when C66 and B2BrBC were administered at lower, chronic doses after STZ application (Experiment 1) , they both reversed the effect of STZ on Irs2 mRNA levels in the pancreas, with the effect of C66 being significantly higher. At higher, acute doses (Experiment 2) , C66 ameliorated Ins1 mRNA levels after STZ treatment. Also, although not statistically significant, at higher doses, both C66 and B2BrBC showed a trend to normalize the suppressing effect of STZ on Glut2 mRNA levels. Overall, our data demonstrate that these two monocarbonyl curcumin analogues have direct effects on the expression of insulin signaling pathway-related genes in the pancreas.

Disclosure
N. Hadzi-Petrushev: None. M. Mladenov: None. J.B. Bogdanov: None. L. Poretsky: None. D. Avtanski: None.

Funding
Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research
560-P: Medical Nutrition Therapy Treatment for Gestational Diabetes
Authors: SHANKAR ANAND 
Published: May 2022

Objective: Gestational Diabetes Mellitus (GDM) is a controversial disorder that can be defined as glucose intolerance or obesity in offspring or unfortunate perinatal complications and outcomes. Inadequate treatment of GDM might lead to foetal complications. This study will aim at assessing the effects of Medical Nutritional Therapy (MNT) as a treatment therapy for pregnant women with gestational diabetes.
Methods: This study was conducted in two center between March to July 2021. A total of 76 patients had been evaluated among whom 20 women had been diagnosed with GDM while the other 56 women had normal tolerance for glucose. Women diagnosed with GDM had received medical nutrition therapy with recommended nuts and olive oil intake.
Results: The HbA1C level of the GDW women (5.1% ± 0.3% (32 ± 0.9 mmol/mol) was higher as opposed to those with Normal tolerance for glucose (NGT) (4.9% ± 0.3% (30 ± 0.9 mmol/mol) , p = 0.001) . In a similar manner, the insulin resistance among the GDM women (24-28 GWs, p = 0.001) was higher. The total weight gain during the pregnancy period was lesser in comparison with the NGT women. Along with these, occurrences of adverse events during pregnancy were lesser among GDW women.
Conclusion: With the help of Medical Nutrition therapy during gestational diabetes management, the outcomes of pregnancies among GDW women can be made similar to those
with NGT. MNT is an effective treatment since it reduces pregnancy complications and enhances outcomes.

Disclosure
A.Shankar: None.
563-P: A Community Health Worker–Led Hypertension and Diabetes Management Program for South Asians in Atlanta: The DREAM Atlanta Study
Authors: SHAH MEGHA K. , WYATT LAURA , GIBBS CHRISTINA C. , MAMMEN SHINU , MOHSIN FARHAN M. , ISLAM NADIA 
Published: May 2022

Background: South Asians are disproportionately affected by type 2 diabetes (DMII) and comorbid hypertension (HTN) , which increases the risk of stroke and myocardial infarction. In Atlanta, South Asians represent one of the fastest growing immigrant populations. Community health worker (CHW) interventions have been shown to improve chronic disease outcomes, yet few tailored interventions have addressed the high burden of cardiovascular disease among South Asians.
Objective: To test the effectiveness of an evidence-based, CHW-led, and culturally-tailored HTN and DMII management program for South Asian adults with DMII and comorbid HTN.
Methods and Study Design: Randomized-Waitlist Controlled Trial Setting/intervention: The treatment group received 5 group virtual DMII and HTN education sessions as well as 2 one-on-one goal setting sessions. The waitlist control group received 3 group virtual sessions at the end of study.
Measures: Primary outcomes included feasibility, acceptability, and change in BP control (systolic blood pressure (SBP) &lt;130 and diastolic blood pressure (DBP) &lt;80) . Secondary outcomes included changes in glycated hemoglobin (HbA1c) , weight, diabetes self-efficacy, healthy eating, and physical activity.
Results: A total of 199 South Asian adults were randomized to treatment or control groups. At 6-month follow-up, 40.2% of the treatment group had controlled BP, compared to 24.2% of the control group (p=0.020) . Absolute change in mean SBP and DBP was significantly greater for the treatment group vs. control group. Weight change was -4.8lbs in the treatment group, compared to +0.6lbs in the control group (p=0.007) . The intervention had an overall retention of 95% (treatment = 92, control=91) .
Conclusions: A culturally-tailored CHW-led intervention is feasible, acceptable, and can significantly improve diabetes and HTN among South Asians. Further study will evaluate the implementation and scalability of the intervention.

Disclosure
M.K.Shah: None. L.Wyatt: None. C.C.Gibbs: None. S.Mammen: None. F.M.Mohsin: None. N.Islam: None.

Funding
NIMHD: K23 MD015088-and 3U54MD000538-17S1
57-LB: Evaluating the Receptiveness to Wear Flash Glucose Monitoring System (FGMS) Sensors in People with Prediabetes—A Feasibility and Acceptability Study
Authors: LEE JOYCE Y. , NGUYEN JENNY T. , ARROYO JEFFREY , TRAN TRACEY , HANAMI DYLAN , MAYORGA JOSE 
Published: May 2022

Flash glucose monitoring system (FGMS) may empower people with prediabetes to become more aware of their glucose impairment, allowing timely lifestyle modification and diabetes prevention. This study aimed to evaluate the feasibility and acceptability of wearing FGMS sensors in people with prediabetes.
We conducted a single-arm, prospective study in two federally qualified health center sites where people with prediabetes were invited to wear FGMS sensors for 28 days through provider referral. Participants with contraindications to wearing sensors were excluded. Feasibility was measured through recruitment rate and total days of sensor wear. Acceptability was measured through a semi-structured interview conducted at the end of the study.
Between July and Dec 2021, a total of 135 eligible participants were identified and referred, of which 46 were uncontactable, 13 were undecided and 45 declined due to disinterest or lack of time, leaving a total of 31 subjects (17 males, 14 females) entering the study. The mean age and duration of prediabetes were 52 and 1.5 years, respectively. The average duration of sensor wear was 25 days. All subjects completed the semi-structured interview with 29 (95%) subjects recommending sensor wear for people with prediabetes.
In conclusion, our study showed that wearing FGMS sensors appeared receptive, with 1 in every 3 contactable persons with prediabetes willing to wear FGMS sensors and reporting positive behavior change.

Disclosure
J. Y. Lee: None. J. T. Nguyen: None. J. Arroyo: None. T. Tran: None. D. Hanami: None. J. Mayorga: None.

Funding
National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health (UL1 TR0001414) . The content is solely the responsibility of the authors and does not necessarilyrepresent the official views of the NIH.
570-P: Household Food Insecurity, Stress, and Anxiety among Youth and Young Adults with Diabetes
Authors: BROWN ANDREA D. , MENDOZA JASON A. , FRONGILLO EDWARD A. , FLORY KATE , REBOUSSIN BETH A. , JENSEN ELIZABETH T. , DOLAN LAWRENCE M. , BELLATORRE ANNA , MALIK FAISAL , MARCOVINA SANTICA M. , PIHOKER CATHERINE , LIESE ANGELA D. 
Published: May 2022

Although household food insecurity (HFI) has been associated with depressive symptoms in youth and young adults (YYA) with youth-onset diabetes, little is known about the association of HFI with other mental health comorbidities. We examined the association of HFI with stress and anxiety symptoms among YYA with diabetes using cross-sectional data from the SEARCH Food Security Cohort study (assessments conducted 2018-2020; n = 1030, age =23.8± 0.3, female =58.8%, type 1 diabetes (T1D) = 881, type 2 diabetes (T2D) =149) . HFI was defined as 3+ affirmations on the USDA Household Food Security Survey Module. The Generalized Anxiety Disorder (GAD-7) and Cohen’s Perceived Stress Scale (PSS-14) were used to assess outcomes of anxiety (score range 0-21) and stress (score range 0-56) , higher scores indicating greater anxiety or stress. Linear regression models were adjusted for age, sex, race/ethnicity, site, diabetes duration, parental education, income, and whether assessment was completed pre/post the coronavirus pandemic. Analyses were stratified by diabetes type. HFI was present in 17.3% of T1D and 35.6 % of T2D. Moderate/severe anxiety symptom scores (range 10-21) were found in 27.5 % (mean=6.9, s.d. =5.5) of T1D and 40.9% (mean=8.4, s.d. =6.5) of T2D. Mean stress scores were 26.7 (s.d.=6.3) for T1D and 27.9 (s.d.=6.3) for T2D. In T1D, HFI was associated with higher anxiety (β=4.8, p=&lt;0.0001) and stress (β=4.9, p=&lt;0.0001) symptom scores compared to those with food security adjusted for covariates. Among T2D, HFI was associated with greater anxiety symptoms (β=2.8, p=0.0247) but no association was observed with stress. These findings suggest that assessing and alleviating HFI may help improve stress and anxiety among YYA with diabetes, and further study is warranted to determine associations over time.

Disclosure
A.D.Brown: n/a. S.M.Marcovina: None. C.Pihoker: None. A.D.Liese: None. J.A.Mendoza: None. E.A.Frongillo: None. K.Flory: None. B.A.Reboussin: None. E.T.Jensen: Consultant; Regeneron Pharmaceuticals Inc. L.M.Dolan: None. A.Bellatorre: None. F.Malik: n/a.

Funding
NIH/NIDDK (1R01DK117461-01) ; NIH/NIDDK/CDC (1UC4DK108173) ; NIH/NIGMS (T32-GM081740)
574-P: Meta-analysis Shows Mind- and Body-Based Interventions Improve Glycemic Control in Patients with Type 2 Diabetes
Authors: SANOGO FATIMATA , XU KEREN , CORTESSIS VICTORIA K. , WEIGENSBERG MARC , WATANABE RICHARD M. 
Published: May 2022

Only 57% of type 2 diabetes (T2D) patients achieve HbA1c &lt;7%. Mind and body practices (MBP) are increasingly used to improve glycemic control inT2D, but individual studies show inconsistent efficacy. We performed a meta-analysis of MBP to assess their overall effect to improve glycemia in patients with T2D. We identified 489 articles with 25 having required HbA1c or fasting glucose measures and meeting other inclusion criteria. Interventions included yoga (n=16) , meditation (n=2) , Qigong (n=2) , guided imagery (n=1) , and mindfulness-based stress reduction (n=4) . We used restricted maximum likelihood random effects modeling to combine individual study results and estimate weighted means and 95% confidence intervals. Heterogeneity was assessed Cochran's Q and I2, bias assessed by funnel plots, and potential sources of heterogeneity assessed using meta regression. Overall, there was a statistically significant and clinically relevant mean reduction in HbA1C (‑0.94%; 95% CI: (-1.23%, -0.65%) ; p=5.4x10-10) . We observed a similar significant mean reduction in fasting glucose (-22.4 mg/dl; 95% CI: (-33.4, -11.6 mg/dl) ; p=5.4x10-5) . Funnel plots revealed no evidence for bias. Significant heterogeneity was observed (Q=71.2; p=2.3x10-9) , which could not be accounted for by variation in duration of the individual interventions (p=0.32) . We conclude MBP results in clinically significant improvement in glycemic control and may be an effective tool to treat patients with T2D.

Disclosure
F.Sanogo: None. K.Xu: None. V.K.Cortessis: None. M.Weigensberg: None. R.M.Watanabe: None.
58-LB: Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice
Authors: CABELLO MIRIAM , ONECA MARÍA , PAJARES MARIA J. , AYO JOSUNE , ENCÍO IGNACIO J. , ARAÑA MIRIAM , BARAJAS MIGUEL 
Published: May 2022

Prediabetes (PreD) , which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D) . Growing evidence suggests the role of the gastrointestinal microbiota in both PreD and T2D, which opens the possibility for a novel nutritional approach, based on probiotics, for improving glucose regulation and delaying disease progression of PreD to T2D. In this light, the present study aimed to assess the antidiabetic properties of Pediococcus acidilactici pA1c (pA1c) in a murine model of high-fat diet (HFD) -induced T2D. For that purpose, C57BL/6 mice were given HFD enriched with either probiotic (1×10E10 CFU/day) or placebo for 12 weeks. We determined body weight, fasting blood glucose, glucose tolerance, HOMA-IR and HOMA-β index, C-peptide, GLP-1, leptin, and lipid profile. We also measured hepatic gene expression (G6P, PEPCK, GCK, IL-1β, and IL-6) and ex-amined pancreatic and intestinal histology (% of GLP-1+ cells, % of goblet cells and villus length) . We found that pA1c supplementation significantly attenuated body weight gain, mitigated glucose dysregulation by reducing fasting blood glucose levels, glucose tolerance test, leptin levels, and insulin resistance, increased C-peptide and GLP-1 levels, enhanced pancreatic function, and improved intestinal histology. These findings indicate that pA1c improved HFD-induced T2D derived insulin resistance and intestinal histology, as well as protected from body weight increase. Together, our study proposes that pA1c may be a promising new dietary management strategy to improve metabolic disorders in PreD and T2D.

Disclosure
M. Cabello: None. M. Oneca: Employee; GENBIOMA APLICACIONES SL. M. J. Pajares: None. J. Ayo: Board Member; Genbioma Aplicaciones S. L., Employee; Genbioma Aplicaciones S. L. I. J. Encío: Other Relationship; Genbioma Aplicaciones SL. M. Araña: None. M. Barajas: None.

Funding
Government of Navarre (Ref 0011-1365-2020-000290) and the European Regional Development Fund (ERDF) . Maria Oneca is supported by Torres-Quevedo grants from the Spanish Ministry of Science and innovation (Ayudas para contratos Torres Quevedo PTQ2019-010384/AEI/10.13039/501100011033)
582-P: Process Evaluation of Dulce Digital–Me: An Adaptive mHealth Intervention for Underserved Hispanics with Diabetes
Authors: SPIERLING BAGSIC SAMANTHA R. , SAVIN KIMBERLY L. , SORIANO EMILY , SAN DIEGO EMILY ROSE N. , ORENDAIN NATALIA , CLARK TAYLOR , SANDOVAL HALEY , CHICHMARENKO MARIYA , PEREZ-RAMIREZ PERLA , FARCAS EMILIA , GODINO JOB G. , PHILIS-TSIMIKAS ATHENA , GALLO LINDA , FORTMANN ADDIE L. 
Published: May 2022

Diabetes self-management education and support improves clinical outcomes in populations disproportionately impacted by type 2 diabetes, including ethnic/racial minorities and individuals of low socioeconomic status. Mobile health (mHealth) interventions have been shown to reduce barriers to accessing these services. The Dulce Digital-Me study sought to integrate adaptive mHealth technologies into diabetes management to enhance self-management support and reduce inequities. This process evaluation uses the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework. The study was effective in reaching a sample that was representative of the intended population, with no differences in baseline clinical characteristics (HbA1c, systolic blood pressure, or LDL cholesterol) between eligible participants who did not (N=261) versus did (N=310) enroll in the study (ps&gt;0.15) . A key informant interview revealed that the medical assistant health coach (MA) found the adoption of the study to be successful in positively impacting patients’ diabetes self-management. Participants across study arms had no significant differences in delivery of mHealth content (ps&gt;0.07) , demonstrating that the intervention was implemented with fidelity. Participants who received Dulce Digital-Me with additional support from an MA were most engaged in responses to ecological momentary assessment prompts (p&lt;0.02) , suggesting utility and acceptability of integrating medical assistants with mHealth interventions. Perceptions of implementation among study participants were positive—with 93% of all participants reporting that the intervention was helpful in managing their diabetes—and were consistent across study arms (p=0.7) . Further studies are warranted to evaluate the efficacy and maintenance of the study following the RE-AIM model to determine whether this intervention warrants expansion to additional settings and patient populations.

Disclosure
S.R.Spierling bagsic: None. E.Farcas: None. J.G.Godino: None. A.Philis-tsimikas: Advisory Panel; Bayer AG, Novo Nordisk, Research Support; Lilly Diabetes, National Institute of Diabetes and Digestive and Kidney Diseases, Novo Nordisk, Viking Therapeutics. L.Gallo: None. A.L.Fortmann: Consultant; Ascensia Diabetes Care, Employee; Dexcom, Inc. K.L.Savin: None. E.Soriano: None. E.N.San diego: None. N.Orendain: None. T.Clark: None. H.Sandoval: None. M.Chichmarenko: None. P.Perez-ramirez: None.

Funding
National Institutes of Health, NIDDK: (R01DK112322) National Institutes of Health, NCATS: (UL1TR002550 & KL2TR002552)
588-P: Examining Psychosocial and Comorbidity Factors Associated with Diabetes Distress among Medicaid Beneficiaries
Authors: VERDECIAS NIKO , MCQUEEN AMY , SMITH RACHEL E. , KREUTER MATTHEW 
Published: May 2022

Evidence supports diabetes distress’ (distress hereafter) effect on diabetes self-management. Few studies have examined factors that influence distress. We used self-reported cross-sectional data from Medicaid beneficiaries in Louisiana to examine psychosocial and clinical factors and their associations with distress. The sample (n=345) was mostly female (75%) , age &gt;45 (77%) , Black (65%) , &gt;years since diabetes diagnosis (51%) , had A1c values ≥7.0% (46%) or unknown (30%) , high distress (71%) , ≥1 social needs (94%) , poor self-rated health (68%) , lower stress (54%) and depression (51%) , more social support (56%) , high # of comorbidities (7.3 ± 2.9) and burden (21.2 ± 11.3) , medication adherence challenges (21%) , and moderately strong self-efficacy (56.0 ± 15.1) . Correlations revealed time since diabetes diagnosis (r= -.11, p&lt;.05) , social support (r= -.28, p&lt;.001) , and self-efficacy (r= -.34, p&lt;.001) were inversely associated with distress. While unemployment (r=.13, p&lt;.05) , A1c (r=.19, p&lt;.05) , more social needs (r=.12, p&lt;.05) , worse self-rated health (r=.32, p&lt;.001) , more stress (r=.16, p&lt;.05) and depression (r=.52, p&lt;.001) , more comorbidities (r=.28, p&lt;.001) and burden (r=.41, p&lt;.001) , and poor medication adherence (r=.19, p&lt;.001) were positively correlated with distress. A multiple linear regression model explained 36% of the variance in distress. Significant factors of distress were less time since diabetes diagnosis (β=-.04, p&lt;.05) , higher A1c (β=.94, p&lt;.05) , higher depression (β=.57, p&lt;.001) , more comorbidity burden (β=.06, p&lt;.001) , and lower self-efficacy (β=-.04, p&lt;.001) . Findings suggest key modifiable factors that may increase distress, warranting research examining strategies to screen and address such factors to improve diabetes self-management.

Disclosure
N.Verdecias: None. A.Mcqueen: None. R.E.Smith: n/a. M.Kreuter: None.

Funding
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK115916)