bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Cost-Effectiveness of First-Line Gemcitabine Plus Nab-Paclitaxel vs FOLFIRINOX in Patients With Advanced Pancreatic Cancer
Authors: Arciero Vanessa , Luo Jin , Parmar Ambica , Dai Wei Fang , Beca Jaclyn M , Raphael Michael J , Isaranuwatchai Wanrudee , Habbous Steven , Tadrous Mina , Earle Craig C , Biagi Jim J , Mittmann Nicole , Arias Jessica , Gavura Scott , Chan Kelvin K W 
Published: June 2022

Abstract

Background
There are no randomized control trials (RCTs) comparing gemcitabine and nab-paclitaxel (Gem-Nab) and fluorouracil, folinic acid, irinotecan, oxaliplatin (FOLFIRINOX) for advanced pancreatic cancer (APC). Although it is well known that RCT-based efficacy often does not translate to real-world effectiveness, there is limited literature investigating comparative cost-effectiveness of Gem-Nab vs FOLFIRINOX for APC. We aimed to examine the real-world cost-effectiveness of Gem-Nab vs FOLFIRINOX for APC in Ontario, Canada.

Methods
This study compared patients treated with first-line Gem-Nab or FOLFIRINOX for APC in Ontario from April 2015 to March 2019. Patients were linked to administrative databases. Using propensity scores and a stabilizing weights method, an inverse probability of treatment weighted cohort was developed. Mean survival and total costs were calculated over a 5-year time horizon, adjusted for censoring, and discounted at 1.5%. Incremental cost-effectiveness ratio and net monetary benefit were computed to estimate cost-effectiveness from the public health-care payer’s perspective. Sensitivity analysis was conducted using the propensity score matching method.

Results
A total of 1988 patients were identified (Gem-Nab: n = 928; FOLFIRINOX: n = 1060). Mean survival was lower for patients in the Gem-Nab than the FOLFIRINOX group (0.98 vs 1.26 life-years; incremental effectiveness = −0.28 life-years [95% confidence interval = −0.47 to −0.13]). Patients in the Gem-Nab group incurred greater mean 5-year total costs (Gem-Nab: $103 884; FOLFIRINOX: $101 518). Key cost contributors include ambulatory cancer care, acute inpatient hospitalization, and systemic therapy drug acquisition. Gem-Nab was dominated by FOLFIRINOX, as it was less effective and more costly. Results from the sensitivity analysis were similar.

Conclusions
Gem-Nab is likely more costly and less effective than FOLFIRINOX and therefore not considered cost-effective at commonly accepted willingness-to-pay thresholds.
A case report of anaplastic carcinoma with osteoclast-like giant cells arising in the pancreatic body
Authors: Kitazono Masaki , Fujita Makoto , Ito Ayaka , Oyama Tomohiro , Ikeda Naotaka , Eguchi Mayumi , Sato Rikiya , Uchiyama Shuichiro , Toyosaki Ryoichi , Yokomakura Naoya , Suenaga Toyokuni , Kusumoto Hirotake , Tsukasa Koichiro 
Published: June 2022

Abstract
The patient is a 58-year-old woman. She was referred to our hospital following a computed tomography scan that revealed a 2-cm tumor-like lesion in the pancreatic body. Endoscopic ultrasound fine-needle aspiration examination revealed a suspected undifferentiated carcinoma with pleomorphic type. The patient was diagnosed with anaplastic carcinoma of the pancreas (ACP) and underwent distal pancreatectomy with lymph nodes dissection. The resected body and tail of the pancreas had a nodular tumor measuring 30 mm in diameter. Histologically, the main lesion of the tumor showed well-differentiated adenocarcinoma, and diffuse proliferation of atypical short spindle cells and round cells accompanied by multinucleated giant cells aggregation was observed around the tubular structure; hence, it was diagnosed with ACP. The postoperative course was uneventful, and the patient was discharged 14 days after the operation. It has already been about 5 years since the surgery, and although the tumor has recurred, the patient is still alive and undergoing chemotherapy.
Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?
Authors: Kasparkova Jana , Kostrhunova Hana , Novohradsky Vojtech , Ma Lili , Zhu Guangyu , Milaeva Elena R , Shtill Alexender A , Vinck Robin , Gasser Gilles , Brabec Viktor , Nazarov Alexey A 
Published: June 2022

Abstract
This work studied the mechanism of action of a Pt(IV) complex 2 bearing two axial lonidamine ligands, which are selective inhibitors of aerobic glycolysis. The presence of two lonidamine ligands in 2 compared to the parent Pt(II) complex increased its antiproliferative activity, cellular accumulation, and changed its cell cycle profile and mechanism of cell death. In 3D cell culture, 2 showed exceptional antiproliferative activity with IC50 values as low as 1.6 μM in MCF7 cells. The study on the influence of the lonidamine ligands in the Pt complex on glycolysis showed only low potency of ligands to affect metabolic processes in cancer cells, making the investigated complex, not a dual- or multi-action prodrug. However, the Pt(IV) prodrug effectively delivers the cytotoxic Pt(II) complex into cancer cells.
OPUSeq simplifies detection of low-frequency DNA variants and uncovers fragmentase-associated artifacts
Authors: Alekseenko Alisa , Wang Jingwen , Barrett Donal , Pelechano Vicent 
Published: June 2022

Abstract
Detection of low-frequency DNA variants (below 1%) is becoming increasingly important in biomedical research and clinical practice, but is challenging to do with standard sequencing approaches due to high error rates. The use of double-stranded unique molecular identifiers (dsUMIs) allows correction of errors by comparing reads arising from the same original DNA duplex. However, the implementation of such approaches is still challenging. Here, we present a novel method, one-pot dsUMI sequencing (OPUSeq), which allows incorporation of dsUMIs in the same reaction as the library PCR. This obviates the need for adapter pre-synthesis or additional enzymatic steps. OPUSeq can be incorporated into standard DNA library preparation approaches and coupled with hybridization target capture. We demonstrate successful error correction and detection of variants down to allele frequency of 0.01%. Using OPUSeq, we also show that the use of enzymatic fragmentation can lead to the appearance of spurious double-stranded variants, interfering with detection of variant fractions below 0.1%.
Magnetic resonance spectroscopic imaging for detecting metabolic changes in glioblastoma after anti-angiogenic therapy—a systematic literature review
Authors: El-Abtah Mohamed E , Talati Pratik , Dietrich Jorg , Gerstner Elizabeth R , Ratai Eva-Maria 
Published: June 2022

Abstract

Background
The impact of anti-angiogenic therapy (AAT) on patients with glioblastoma (GBM) is unclear due to a disconnect between radiographic findings and overall survivorship. MR spectroscopy (MRS) can provide clinically relevant information regarding tumor metabolism in response to AAT. This review explores the use of MRS to track metabolic changes in patients with GBM treated with AAT.

Methods
We conducted a systematic literature review in accordance with PRISMA guidelines to identify primary research articles that reported metabolic changes in GBMs treated with AAT. Collected variables included single or multi-voxel MRS acquisition parameters, metabolic markers, reported metabolic changes in response to AAT, and survivorship data.

Results
Thirty-five articles were retrieved in the initial query. After applying inclusion and exclusion criteria, 11 studies with 262 patients were included for qualitative synthesis with all studies performed using multi-voxel 1H MRS. Two studies utilized 31P MRS. Post-AAT initiation, shorter-term survivors had increased choline (cellular proliferation marker), increased lactate (a hypoxia marker), and decreased levels of the short echo time (TE) marker, myo-inositol (an osmoregulator and gliosis marker). MRS detected metabolic changes as soon as 1-day after AAT, and throughout the course of AAT, to predict survival. There was substantial heterogeneity in the timing of scans, which ranged from 1-day to 6–9 months after AAT initiation.

Conclusions
Multi-voxel MRS at intermediate and short TE can serve as a robust prognosticator of outcomes of patients with GBM who are treated with AAT.
Social Dilemmas
Authors: Arora Poonam , Kugler Tamar , Giardini Francesca 
Published: June 2022

AbstractSocial dilemmas are interdependent decisions where the outcomes depend upon choices made by every decision maker. Importantly, the incentive structure sets up a dominant strategy of non-cooperation such that everyone ends up worse off than if all had cooperated, but each individual is better off not cooperating regardless of what others do. Thus, social dilemmas are mixed-motive situations that require a choice between short-term individual gain and long-term collective gain. Social dilemma researchers have adopted a variety of approaches to studying cooperation ranging from considering it as a constructed context-dependent choice that is affected by incentives and economic nudges, group affiliation, norms, and social nudges, while others investigate individual differences and personal perceptions of value. This chapter organizes current topical knowledge through the lens of the Theory of Planned Behavior (TPB), where cooperation is the expressed behavior when an intent to cooperate emerges (consciously or sub-consciously) from a positive attitude towards the act of cooperating, from a dominant cooperative norm, or the interaction of attitude and norms, and is supported by the perception that one has the freedom to cooperate (behave cooperatively). The chapter provides a broad review of the field to understand mechanisms that both increase likelihood of cooperative behavior and those that result in cooperative breakdowns, as well as possible solutions to further effective cooperation.
Psychobiology of Competition: A Review of Men’s Endogenous Testosterone Dynamics
Authors: Bird Brian M. , Bochon Lindsay , Wu Yin , Zilioli Samuele 
Published: June 2022

Abstract
Competition is a defining feature of most living organisms. Among humans, the engagement in, and the associated outcomes of, competition (i.e., win or loss) can hold important consequences for survival, individual and group status, and mating-related opportunities. As such, considerable research efforts have been devoted to identifying and delineating the factors that influence human competitive decision-making. The steroid hormone testosterone, in particular, has been identified as one such factor, not only influencing competitive decision-making and behavior, but also responding flexibly to competitive cues and outcomes to then feedback to ongoing pursuits. Growing evidence suggests that the extent to which testosterone exerts its effects may depend on variables across a number of domains, such as individual preferences or dispositions, social cues, and other hormones. This chapter provides an overview of such competitive biopsychology with a focus on men’s testosterone dynamics. The authors provide a brief introduction to testosterone, and a summary of some of the key theoretical approaches to understanding testosterone dynamics in humans, followed by an overview of correlational and experimental studies that examine the independent and interactive effects of testosterone on competition and competition-related variables.
Which Globalization? Whose World Music? On Historicizing, Particularizing, and Finding Value
Authors: Taylor Timothy D. 
Published: June 2022

Abstract
This chapter makes a plea for more empirically grounded studies of globalization, offering a case study of the rise of the international music industry in the early twentieth century in East Asia. The invention of technology that made possible the mass reproduction of sound recordings in 1900 necessitated the creation of inventory in what Anna Tsing has called supply-chain capitalism, one way that firms create capitalist economic value. This chapter also argues that much of what passes for theorizing in the music fields is over-generalized, that we need to continue to pay attention, whether ethnographically, historically, or some other way, to what is going on in the lives of the people we study, and that considering what those people value is a good way to start.
Roman Catholic Sacred Space
Authors: Primiano Leonard Norman 
Published: June 2022

Abstract
Pre-Christian world views of the animated universe had a profound impact on the developing religion. Especially influential on the tradition known as Roman Catholicism was an understanding and appreciation of sacred space that perfectly captures the sense of omnipresent sacredness—of sacredness in domestic and natural spaces—that is the legacy of pre-Christian habitus. This discussion of Catholic space and the places inhabited by this tradition’s sense of presence, materiality, and aesthetics seeks not a synthesis of “Catholic” space, but of “Catholics’ ” spaces. The chapter invites readers to open their minds to the intrinsic Catholic sensibility of the omnipotent sacredness found in natural and built environments, from the mountains to a special tree to the desert to ecclesiastical and domestic enclosures (from vast cathedrals to home altars), and in the layered decoration that is emblematic of the materialization of Roman Catholic vernacular religion.
The Impermanence of Religious Space
Authors: Kilde Jeanne Halgren 
Published: June 2022

Abstract
Although the materiality of churches, synagogues, mosques, and other religious buildings implies permanence, their presence and their congregations in specific locations, or “religioscapes,” are in constant flux. This chapter argues that our understanding of these changes is limited because our interpretive frameworks have been too narrow. It identifies and examines two frameworks that have dominated scholarly and media discourse: the conquer and vanquish model that views change as a result of conflict, and the progress or decline model that views change as a result of immigrant assimilation or secularization. Arguing that these perspectives mask other motivations and processes that drive change, the chapter builds on a case study of religious sites in Minneapolis and St. Paul, Minnesota, to propose an alternative framework that approaches religioscapes as spaces of encounter that function constitutively in the development of religious pluralism and where change is motivated by internal congregational factors and external pressures.
Sites of Miracles and Other Holy Places
Authors: Hendrickson Brett 
Published: June 2022

Abstract
This chapter examines sites of miracles by focusing on a case study of the Santuario de Chimayó, a church in New Mexico known for miraculous healing and pilgrimage. It describes the Santuario’s history and contemporary characteristics to illumine the complex encounters between various stakeholders at the site. Pueblo people, Hispanic New Mexicans, Catholic clergy, and thousands of tourists all lay claim to the miraculous at the Santuario in ways that sometimes complement each other and sometimes compete. The chapter suggests that the present case study of the Santuario, rather than providing a universal template for all miracle sites, instead provides a compelling point of comparison for other such sites.
Exploration of Religious Spaces in Western Africa
Authors: Dei Daniel 
Published: June 2022

Abstract
This chapter focuses on the character and significance of religious spaces in Western Africa. An examination of the nature of Western African communities reveals many physical structures, thought patterns, emotional expressions, and symbols that have acute religious implications. Combining the structuralist-hermeneutical and sociohistorical approaches, it probes the question, What is the nature and significance of religious spaces in Western Africa? The chapter examines four types of religious spaces and reveals that religious spaces continue to define the individual and corporate identity of Western Africans in the twenty-first century. These influences are perceptible in terms of the thoughts, actions, and emotional expressions of the Western African, touching on, but not limited to, historical and religiocultural heritage, spirituality, world view, ecological preservation, existential stability, and moral stability. In this regard, it is recommended that religious spaces in Western Africa be preserved against going extinct.
Playing in the Borderlands
Authors: Gilman Vee , Reed Rachel , bautista ezequiel , Taylor Arnett Ashley , Perkins Freddy , Hadley Susan 
Published: June 2022

Abstract
Music therapy pedagogy has traditionally been defined by rigid roles and structures, including fixed teacher/learner identity categories, systematized hierarchies of knowledge and communication, cultural and musical gatekeeping practices, and standardized musical, clinical, and professional competencies. These structures represent narrowly defined borders which limit who enters the profession, how we understand human variability, and whose knowledges are acceptable within the field of music therapy. This chapter aims to destabilize long-held oppressive categorizations and emphasizes generative liminal spaces as opportunities to experience radically inclusive relationships. We believe that these relationships are key to the transformative learning process of understanding ourselves, others, and the worlds we inhabit. We engage queer theory literature to establish key tenets of ‘queering’ as an active practice applicable beyond gender and sexuality to include other socially constructed identity categories such as race and disability. We then move beyond identity categories themselves to address systemic educational and institutional practices.
Ethnography in Comparative Environmental Politics
Authors: Pacheco-Vega Raul 
Published: June 2022

Abstract
Ethnography—the systematic observation of populations and communities with the intention of learning about the cultural inner workings of a societal group—is part of a larger suite of qualitative methods available to researchers in comparative environmental politics (CEP). This chapter showcases the application of a qualitative research strategy that pays attention to the potential vulnerabilities of the communities under study. It draws on original research on bottled water consumption and informal waste picking to show how a doubly engaged ethnography has the potential to yield robust insights into the comparative environmental politics of resource governance. It explains how CEP as a field can benefit from using doubly engaged ethnography as a methodological framework by focusing on the study of unorthodox commons and their usage by vulnerable populations, utilizing examples from across the world.
The Regional Novel and the Novel of the Mexican Revolution on Common Ground
Authors: Mitchell Tamara L. , Smith Amanda M. 
Published: June 2022

Abstract
This chapter focuses on the common ground tread by the Latin American regional novel and the novel of the Mexican Revolution, namely, a shared preoccupation with questions of land sovereignty and land ownership. While the two narrative modes are often considered separate literary phenomena, this chapter argues for evaluating them together as critical responses to the reorganization of Latin American economies, politics, and cultures by neocolonial interests. Focusing on an emblematic novel from each category—José Eustasio Rivera’s La vorágine (The Vortex, 1924) and Martín Luis Guzmán’s El águila y la serpiente (The Eagle and the Serpent, 1928), this analysis charts a more expansive geography of the presence of tierra in the Latin American novel and proposes an alternative shared legacy of such works.
Financial Systems
Authors: Quaglia Lucia 
Published: June 2022

Abstract
Financial systems and the governance of global finance are key topics in International Political Economy (IPE) given the massive size of the financial sector worldwide, the mobility of finance, the cross-border nature of many financial services, the devastation caused by financial crises, and the link between finance and the real economy. This chapter reviews the existing literature on financial systems and the governance of finance in IPE. It first outlines the main theoretical approaches that have been used. It then takes stock from the existing works in the field, discussing to what extent various bodies of scholarly works speak to each other, and identifying blind spots in the literature. It is argued that, like other fields of IPE, the academic literature on the governance of financial systems has become largely problem-centered, meaning that, rather than contributing to specific “schools of thought,” most research engages with real-world questions, first and foremost, how to prevent and manage financial crises in the context of the multi-level governance of finance and how to study and understand the increased complexity of financial systems.
Implementation Initiatives to Improve Low Back Pain Care in Australia: A Scoping Review
Authors: Costa Nathalia , Blyth Fiona M , Amorim Anita B , Parambath Sarika , Shanmuganathan Selvanaayagam , Huckel Schneider Carmen 
Published: June 2022

Abstract

Objective
This scoping review aimed to comprehensively review strategies for implementation of low back pain (LBP) guidelines, policies, and models of care in the Australian health care system.

Methods
A literature search was conducted in MEDLINE, EMBASE, CINAHL, Allied and Complementary Medicine Database, and Web of Science to identify studies that aimed to implement or integrate evidence-based interventions or practices to improve LBP care within Australian settings.

Results
Twenty-five studies met the inclusion criteria. Most studies targeted primary care settings (n = 13). Other settings included tertiary care (n = 4), community (n = 4), and pharmacies (n = 3). One study targeted both primary and tertiary care settings (n = 1). Only 40% of the included studies reported an underpinning framework, model, or theory. The implementation strategies most frequently used were evaluative and iterative strategies (n = 14, 56%) and train and educate stakeholders (n = 13, 52%), followed by engage consumers (n = 6, 24%), develop stakeholder relationships (n = 4, 16%), change in infrastructure (n = 4, 16%), and support clinicians (n = 3, 12%). The most common implementation outcomes considered were acceptability (n = 11, 44%) and adoption (n = 10, 40%), followed by appropriateness (n = 7, 28%), cost (n = 3, 12%), feasibility (n = 1, 4%), and fidelity (n = 1, 4%). Barriers included time constraints, funding, and teamwork availability. Facilitators included funding and collaboration between stakeholders.

Conclusions
Implementation research targeting LBP appears to be a young field, mostly focusing on training and educating stakeholders in primary care. Outcomes on sustainability and penetration of evidence-based interventions are lacking. There is a need for implementation research guided by established frameworks that consider interrelationships between organizational and system contexts beyond the clinician–patient dyad.