bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of early mortality risk in patients with epithelial ovarian cancer
Authors: Okunade Kehinde S. , John‐Olabode Sarah , Ohazurike Ephraim O. , Soibi‐Harry Adaiah , Osunwusi Benedetto , Anorlu Rose I. 
Published: July 2022

AbstractBackgroundTo improve the overall survival of epithelial ovarian cancer (EOC) patients, a more precise risk identification after completion of standard treatment will enhance patients' follow‐up surveillance and the use of individualized targeted therapy.AimThis study explored the potential risk predictors of early mortality in EOC patients who had standard treatment with debulking surgery and chemotherapy.MethodsThe study included 93 EOC patients who had standard treatment and were followed up between January 2011 and December 2020. The sociodemographic, clinical, and laboratory data of patients with EOC including the update on their 3‐year follow‐up status were retrospectively collected and analyzed. Early mortality is defined as the death of a patient within 3 years of completion of standard treatment. Patients' data were computed using descriptive statistics and the associations between patients' factors and the risk of early mortality were tested using the binary logistic regression model.ResultsEarly deaths occurred in 36 (38.7%) of patients with EOC. In the final multivariate analyses, early tumor relapse within 6‐months of treatment completion was the only independent risk factor that predicts early mortality in EOC patients (risk ratio = 8.6, 95% confidence interval: 3.3–24.5, p < 0.01).ConclusionOur study suggests that early tumor relapse may be a useful surrogate of early mortality in EOC. However, our findings should be interpreted with caution pending further corroboration through an adequately powered, prospective multicenter study.
A study of the comparative effect of cerium oxide and cerium peroxide on stimulation of angiogenesis: Design and synthesis of pro‐angiogenic chitosan/collagen hydrogels
Authors: Zubairi Waliya , Tehseen Saimoon , Nasir Muhammad , Anwar Chaudhry Aqif , Ur Rehman Ihtesham , Yar Muhammad 
Published: July 2022

AbstractPoor angiogenesis at injury site is a major problem in chronic wounds, which could lead to limbs amputation in adverse cases. To overcome this issue, several efforts have made in literature and by our group as well to develop pro‐angiogenic agents. For this purpose, metal oxides due to their oxidative potential have been studied and found very attractive agents. Cerium oxides are proven to be non‐toxic and their biological studies have already proved their importance in preventing chronic inflammation, and neurological diseases among several others by modulating the intracellular reactive oxygen species. In current study, we report the synthesis and neovascularization activity of cerium oxide and cerium peroxide nanoparticles when loaded into chitosan and collagen hydrogel. The hydrogels were characterized by FTIR, SEM and XRD. The pro‐angiogenic behavior of these hydrogels was studied by in‐vivo CAM assay. It was found that cerium peroxide loaded material showed significantly increase in angiogenesis as compared to cerium oxide loaded materials. It was demonstrated that cerium peroxide hydrogels enhanced the angiogenic capability in CAM assay as compared to cerium oxide and hence holds good potential for chronic ulcer and burn wounds healing.
An integrative review of gift‐giving research in consumer behavior and marketing
Authors: Givi Julian , Birg Laura , Lowrey Tina M. , Galak Jeff 
Published: July 2022

AbstractIn recent decades, scholars across all areas of marketing have studied consumer gift‐giving behavior. Despite the growing popularity of this research topic, no extensive review of the gift‐giving literature exists. To that end, this paper offers an expansive review of research on consumer gift‐giving, focusing primarily on work coming from within the marketing discipline, but also drawing on foundational pieces from other fields. We review extant scholarship on five of gift‐giving's most important aspects—givers' motivations, givers' inputs, giver‐recipient mismatches, value creation/reduction, and the greater gift‐giving context. In doing so, we illuminate the literature's key agreements and disagreements, shed light on themes that traverse ostensibly disparate gift‐giving findings, and develop deeper conceptualizations of gifting constructs. Moreover, we identify opportunities for improvement in the gift‐giving literature and use them to create key agendas for future gift‐giving research. In sum, this paper offers a single point of reference for gift‐giving scholars, improves academia's current understanding of gift‐giving, offers several theoretical contributions, and generates multiple paths for future research.
Incivility in online learning environment: Perception of dental students and faculty
Authors: Farid Huma , Hasan Sana Jalil , Naveed Ayesha , Hyder Pakiza Raza , Shaikh Gul Muhammad , Pasha Lubna 
Published: July 2022

AbstractObjectivesThe objectives of this study were to assess the extent of incivility and perception of dental students and faculty regarding uncivil behaviors in the online learning environment.MethodsIncivility in online environment (IOLE) survey was used to collect data from dental students (n = 232) and faculty (n = 35) at Margalla Institute of Health Sciences, Rawalpindi, Pakistan from September to December 2021. A 4‐ point Likert scale was used for respondents to indicate their perceptions regarding incivility in IOLE, and a list of students’ and faculty's uncivil behaviors. Descriptive analysis, chi‐square test, and Spearman's correlation coefficient were used for data analysis. The level of significance was kept at ≤0.05.ResultsThe majority of the students reported online incivility as either “a moderate or serious problem” (n = 103, 72.0%), and the majority of faculty (n = 12, 56%) reported incivility as “no to a mild problem” (p = 0.018). Both students and faculty agreed that students are more likely to engage in uncivil behavior in OLE as compared to faculty. Various forms of rude/threatening comments and posting ambiguous or vague responses that do not add meaning to the online discussion were considered uncivil student behaviors by both students and faculty (p ≤ 0.05). Assigning grades without providing useful feedback and threatening to fail students for not complying with faculty's demands were perceived as uncivil faculty behaviors (p ≤ 0.05). Female students and students with less self‐reported expertise in online learning had greater mean scores for faculty uncivil behaviors (p ≤ 0.05).ConclusionIncivility exists in OLE in dentistry with the more likely engagement of students in uncivil behaviors. With the increasing use of online platforms for education in dentistry, there is a need for further research and training courses for both students and faculty to reduce the extent of incivility and create a healthy and conducive learning environment.
Cortical thickness abnormalities in attention deficit hyperactivity disorder revealed by structural magnetic resonance imaging: Newborns to young adults
Authors: Levman Jacob , Forgeron Cynthia , Shiohama Tadashi , MacDonald Patrick , Stewart Natalie , Lim Ashley , Berrigan Lindsay , Takahashi Emi 
Published: July 2022

AbstractAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition for which we have an incomplete understanding, and so brain imaging methods, such as magnetic resonance imaging (MRI), may be able to assist in characterising and understanding the presentation of the brain in an ADHD population. Statistical and computational methods were used to compare participants with ADHD and neurotypical controls at a variety of developmental stages to assess detectable abnormal neurodevelopment potentially associated with ADHD and to assess our ability to diagnose and characterise the condition from real‐world clinical MRI examinations. T1‐weighted structural MRI examinations (n = 993; 0–31 years old [YO]) were obtained from neurotypical controls, and 637 examinations were obtained from patients with ADHD (0–26 YO). Measures of average (mean) regional cortical thickness were acquired, alongside the first reporting of regional cortical thickness variability (as assessed with the standard deviation [SD]) in ADHD. A comparison between the inattentive and combined (inattentive and hyperactive) subtypes of ADHD is also provided. A preliminary independent validation was also performed on the publicly available ADHD200 dataset. Relative to controls, subjects with ADHD had, on average, lowered SD of cortical thicknesses and increased mean thicknesses across several key regions potentially linked with known symptoms of ADHD, including the precuneus and supramarginal gyrus.
Changes in swine ammonia emissions associated with improved production management
Authors: Harper Lowry A. , Weaver Kim H. , Duffin Sarah M. , Coffey M. Terry 
Published: July 2022

AbstractSwine manure management and storage have been implicated as major sources of increasing agricultural ammonia (NH3) emissions resulting in increased ammonium deposition in North Carolina. This study was conducted to establish how improvements in manure and animal management have affected lagoon nutrient loading and subsequent NH3 emissions determined from measured lagoon chemistry and climate data. Archived lagoon chemistry analyses from 182 farm lagoons (106,000 sample analyses) were used to evaluate trends in lagoon chemical properties. Process and empirical (statistical) NH3 volatilization models were used with the data to calculate changes in NH3 emissions from 2001 through 2018. Lagoon nutrient trends for finisher and sow farms showed that annual averages of nutrients had decreases ranging from 18 to 93%, except for a 41% increase in copper for finisher primary lagoons. Because of reduced nitrogen and pH in the lagoons, a process model of NH3 emissions suggested decreases from primary lagoons of 49 and 25% from finisher and sow farm lagoons, respectively. Empirical (statistical) models predicted even larger relative NH3 decreases (up to 54%).
Plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy induced by type 2 diabetes mellitus
Authors: Wang Guo‐Qiang , Wang Fei‐Xiang , He Yi‐Na , Lin Jing‐Yan 
Published: July 2022

AbstractThe glymphatic system is a recently discovered glial‐dependent macroscopic interstitial waste clearance system that promotes the efficient elimination of soluble proteins and metabolites from the central nervous system. Its anatomic foundation is the astrocytes and aquaporin‐4 (AQP4) water channels on the endfeet of astrocytes. The aim of this study is to evaluate the plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy (PDN) induced by type 2 diabetes mellitus. PDN rats were modeled under a high‐fat and high‐glucose diet with a low dose of streptozotocin. MRI was applied to observe the infiltration and clearance of contrast to indicate the functional variability of the glymphatic system at the spinal cord level. The paw withdrawal threshold was used to represent mechanical allodynia. The numerical change of glial fibrillary acidic protein (GFAP) positive astrocytes was assessed and the polarity reversal of AQP4 protein was measured by immunofluorescence. As a result, deceased contrast infiltration and clearance, enhanced mechanical allodynia, increased number of GFAP positive astrocytes, and reversed polarity of AQP4 protein were found in the PDN rats. The above molecular level changes may contribute to the impairment of the spinal glymphatic system in PDN rats. This study revealed the molecular and functional variations of the spinal glymphatic system in PDN rats and for the first time indicated that there might be a correlation between the impaired spinal glymphatic system and PDN rats.
Effect of excipient wall materials on the development of ginger oleoresin microcapsules: assessing the physicochemical, antioxidant and structural properties
Authors: Ahad Tehmeena , Gull Amir , Masoodi Farooq Ahmad , Nissar Jasia , Masoodi Lubna , Sajad Wani Mohd 
Published: July 2022

AbstractBACKGROUNDGinger oleoresin is prone to destruction from air, light and high temperatures and has a limited shelf life if kept improperly. Its viscous and sticky characteristics also make it difficult to handle and utilize. These issues can be solved via microencapsulation. The goal of this research was to evaluate how different wall materials affect the properties of microencapsulated ginger oleoresin powder.RESULTSGinger oleoresin microcapsules were developed through spray drying technique using gum acacia (GA) and whey protein isolate (WPI) as wall materials. The characteristics of the obtained powder, including water activity, wettability and encapsulation efficiency, were evaluated, corresponded to values of 0.20, 90.54 s and 84.15% for whey protein isolate‐based ginger oleoresin powder. Whey protein isolate microcapsules also exhibited higher phenolic content (27.26 mg gallic acid equivalents g−1), total flavonoid (2.94 mg quercetin equivalents g−1) and 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activity (68.71%) than GA microcapsules. Both WPI‐ and GA‐based oleoresin microcapsules displayed poor flowability, but possessed a metastable amorphous state as indicated by X‐ray diffraction. GA‐encapsulated oleoresin microcapsules showed a significant increase in particle size (1983 nm) compared to WPI oleoresin microcapsules. Fourier transform infrared analysis of the developed oleoresin microcapsules indicated no change in molecular structure except for a variation in peak intensity.CONCLUSIONWhey protein isolate proved to be more efficient in maintaining the physicochemical and antioxidant activity of spray‐dried ginger oleoresin powder. The present study revealed whey protein‐based oleoresin powder could be used as a therapeutic agent in various nutraceutical applications. © 2022 Society of Chemical Industry.
Augmentation and vocal fold biomechanics in a recurrent laryngeal nerve injury model
Authors: Miar Solaleh , Walters Benjamin , Gonzales Gabriela , Malka Ronit , Baker Amelia , Guda Teja , Dion Gregory R. 
Published: July 2022

AbstractObjectives/hypothesisComposite vocal fold (VF) biomechanical data are lacking for augmentation after recurrent laryngeal nerve (RLN) injury. We hypothesize resulting atrophy decreases VF stiffness and augmentation restores native VF biomechanics.MethodsSixteen Yorkshire Crossbreed swine underwent left RLN transection and were observed or underwent carboxymethylcellulose (CMC) or calcium hydroxyapatite (CaHa) augmentation at 2 weeks. Biomechanical measurements (structural stiffness, displacement, and maximum load) were measured at 4 or 12 weeks. Thyroarytenoid (TA) muscle cross‐sectional area was quantified and compared with two‐way ANOVA with Tukey's post hoc test.ResultsAfter 4 weeks, right greater than left structural stiffness (mean ± SE) was observed (49.6 ± 0.003 vs. 28.4 ± 0.002 mN/mm), left greater than right displacement at 6.3 mN (0.54 ± 0.01 vs. 0.46 ± 0.01 mm, p < .01) was identified, and right greater than left maximum load (72.3 ± 0.005 vs. 40.8 ± 0.003 mN) was recorded. TA muscle atrophy in the injured group without augmentations was significant compared to the noninjured side, and muscle atrophy was seen at overall muscle area and individual muscle bundles. CMC augmentation appears to maintain TA muscle structure in the first 4 weeks with atrophy present at 12 weeks.ConclusionsVF biomechanical properties match TA muscle atrophy in this model, and both CMC and CaHa injection demonstrated improved biomechanical properties and slower TA atrophy compared to the uninjured side. Taken together, these data provide a quantifiable biomechanical basis for early injection laryngoplasty to improve dysphonia and potentially improve healing in reversible unilateral vocal fold atrophy.Level of evidenceN/A
Climatological study of airflow channelling in relation to surface geostrophic wind
Authors: Sato Ryogo , Kusaka Hiroyuki 
Published: July 2022

AbstractThe aim of this study was to climatologically investigate forced and pressure‐driven channelling flow in the Kitakami Basin, Japan, through the use of observational surface wind and sea‐level pressure data collected over 23 years, which corresponded to 15,584 channelling flow events. Our results indicated that forced channelling tends to occur when the direction of the surface geostrophic wind is parallel to the valley axis. Contrastingly, pressure‐driven channelling tends to occur when the component perpendicular to the valley axis of the surface geostrophic wind is larger than that parallel to the valley axis of the surface geostrophic wind. The channelling flow type was determined by the wind direction of the surface geostrophic wind, which was more pronounced when the mountain Froude number of the flow across the valley was less than 1. This indicates that the type of channelling flow depends on the surface geostrophic wind speed. Moreover, neither channelling flow type was dominant when the component parallel to the valley axis of the surface geostrophic wind was slightly larger than the orthogonal component. This suggests that the flow type cannot be explained using the surface geostrophic wind alone, irrespective of whether forced channelling or pressure‐driven channelling is dominant.
Monochorionic twins with 15q26.3 duplication presenting with selective intrauterine growth restriction and discordant cardiac anomalies: A case report
Authors: Kannan Suraj , Bodurtha Joann N. , Hamosh Ada , Jordan Christopher 
Published: July 2022

AbstractBackgroundDuplication of the distal end of chromosome 15q has been previously implicated in a characteristic overgrowth syndrome. Additionally, many patients have other congenital malformations, including cardiac, renal, genital, and musculoskeletal anomalies. However, some patients may present with intrauterine growth restriction and short stature. Different breakpoints within 15q, as well as different environmental factors, may underlie these varied presentations.Case PresentationWe discuss monochorionic‐diamniotic twins with a ~345 kb maternally inherited duplication in 15q26.3. The twins presented with discordant pathology—one twin with a single umbilical artery, selective intrauterine growth restriction, and multiple cardiac defects including aortic coarctation, aortic valve stenosis, and ventricular septal defect, whereas the other twin was unaffected. To our knowledge, this case represents the smallest reported duplication of distal 15q.ConclusionThe discordant phenotype seen in the twins is likely due to a complex interplay between genetic and environmental causes. The affected infant presented prenatally with growth restriction and a single umbilical artery rather than overgrowth, potentially due to a unique breakpoint within 15q. This, in turn, may have produced hemodynamic perturbations between the twins, leading to discordant cardiac disease. Our report thus highlights the importance of genetic and nongenetic mechanisms underlying discordant anomalies in monochorionic twins.
Calculation of the relative basicity of three α,ω‐diphenylpolyenes with trifluoroacetic acid
Authors: Masthay Mark B. , McLean Jack B. , Santos Ariana L. , Pirlo Russell K. , Biffinger Justin C. 
Published: July 2022

AbstractLinear polyenes are an important class of compounds containing two or more alternating carbon‐carbon double and single bonds that are soluble primarily in organic non‐polar solvents. However, determining the relative basicity of unsubstituted polyenes experimentally has proven to be challenging in practice because such studies require mixing non‐polar polyene‐organic solvent mixtures with high concentrations of moderately polar organic acids. In this study, we used both computational and experimental approaches to calculate potential sites of protonation of trans‐1,4‐diphenyl‐1,3‐butadiene (DPB), all trans‐1,6‐diphenyl‐1,3,5‐hexatriene (DPH), and all trans‐1,8‐diphenyl‐1,3,5,7‐octatetraene (DPO) with trifluoroacetic acid (TFAH) in both n‐hexane or benzene solvents. Density functional theory (DFT) calculations with a 6‐311 + G (d,p) basis set and the B3LYP exchange correlation functional predict that the carbon atoms α to either phenyl ring are the most likely sites of protonation. Our calculations indicate that the basicities of the DPPs increase with increasing length of the polyene moiety (DPO > DPH >> DPB) in the gas phase and in both benzene and n‐heptane solvents. Consistent with these computational predictions, the experimental rates of protonation of DPB, DPH, and DPO in benzene and hexane were consistent with the calculated basicity trends. Dynamic light scattering data confirmed that these reactions were phase separated resulting in emulsions between TFAH and both solvents; these phase separations complicated specification of the actual reaction rates. Finally, GC‐MS and NMR data confirm that the crude products from the protonation of DPB and DPH were mixtures of DPB and DPH dimers. In significant contrast, DPO did not form dimers but rather an unidentified monomeric trifluoroacetate addition product.
Baseline sensitivity of European Zymoseptoria tritici populations to the complex III respiration inhibitor fenpicoxamid
Authors: Kildea Steven , Hellin Pierre , Heick Thies M. , Hutton Fiona 
Published: July 2022

AbstractBACKGROUNDFenpicoxamid is a recently developed fungicide belonging to the quinone inside inhibitor (QiI) group. This is the first fungicide within this group to be active against the Zymoseptoria tritici, which causes Septoria tritici blotch on wheat. The occurrence of pre‐existing resistance mechanisms was monitored, using sensitivity assays and Illumina sequencing, in Z. tritici populations sampled in multiple European countries before the introduction of fenpicoxamid.RESULTSAlthough differences in sensitivity to all three fungicides tested (fenpicoxamid, fentin chloride and pyraclostrobin) existed between the isolate collections, no alterations associated with QiI resistance were detected. Among the isolates, a range in sensitivity to fenpicoxamid was observed (ratio between most sensitive/least sensitive = 53.1), with differences between the most extreme isolates when tested in planta following limited fenpicoxamid treatment. Sensitivity assays using fentin chloride suggest some of the observed differences in fenpicoxamid sensitivity are associated with multi‐drug resistance. Detailed monitoring of the wider European population using Illumina‐based partial sequencing of the Z. tritici also only detected the presence of G143A, with differences in frequencies of this alteration observed across the region.CONCLUSIONSThis study provides a baseline sensitivity for European Z. tritici populations to fenpicoxamid. Target‐site resistance appears to be limited or non‐existing in European Z. tritici populations prior to the introduction of fenpicoxamid. Non‐target site resistance mechanisms exist, but their impact in the field is predicted to be limited. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.