bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does attention‐deficit/hyperactivity disorder increase the risk of minor blunt head trauma in children?
Authors: Pakyurek Murat , Badawy Mohamed , Ugalde Irma T. , Ishimine Paul , Chaudhari Pradip P. , McCarten‐Gibbs Kevan , Nobari Ozra , Kuppermann Nathan , Holmes James F. 
Published: August 2022

AbstractProblemIt is unclear if attention‐deficit hyperactivity disorder (ADHD) increases the risk of head trauma in children.MethodsWe conducted a multicenter prospective observational study of children with minor blunt head trauma. Guardians were queried, and medical records were reviewed as to whether the patient had previously been diagnosed with ADHD. Enrolled patients were categorized based on their mechanism of injury, with a comparison of those with motor vehicle collision (MVC) versus non‐MVC mechanisms.FindingsA total of 3410 (84%) enrolled children had ADHD status available, and 274 (8.0%; 95% confidence interval, CI: 7.1, 9.0%) had been diagnosed with ADHD. The mean age was 9.2 ± 3.5 years and 64% were males. Rates of ADHD for specific mechanisms of injury were: assaults: 23/131 (17.6%; 95% CI 11.5, 25.2%), automobile versus pedestrian 23/173 (13.3%; 95% CI: 8.6, 19.3%), bicycle crashes 26/148 (17.6%; 95% CI: 11.8, 24.7%), falls 107/1651 (6.5%; 95% 5.3, 7.8%), object struck head 31/421 (7.4%; 5.1, 10.3%), motorized vehicle crashes (e.g., motorcycle, motor scooter) 11/148 (7.4%; 3.8, 12.9%), and MVCs 46/704 (6.5%; 95% CI: 4.8, 8.6%).ConclusionChildren with ADHD appear to be at increased risk of head trauma from certain mechanisms of injury including assaults, auto versus pedestrian, and bicycle crashes but are not at an increased risk for falls.
Which factors affect internalized stigmatization in adolescents with mental disorders?
Authors: Dikeç Gül , Bilaç Öznur , Kardelen Cansın , Sapmaz Şermin Yalın , Kandemir Hasan 
Published: August 2022

AbstractPurposeThe aim of this descriptive study was to determine the factors affecting internalized stigmatization of adolescents with mental disorders.MethodThe study data were collected in a university hospital between August 1, 2020 and July 30, 2021 (n = 123), using a Personal information form and the Internalized Stigmatization of Mental Illness‐Adolescent Form (ISMI‐AF).ResultsGender and the number of hospitalizations were determined to be independent variables with explanatory power in the ISMI‐AF, and in the model created with these variables, it was determined that these variables explained 18% of the change in the total points of the ISMI‐AF.ConclusionsIt could be recommended that psychosocial programs are developed with the aim of decreasing internalized stigmatization and increasing the psychological resilience of adolescents.
Extraction and properties of glutinous rice bran protein obtained by the mild alkaline extraction for the bran combined with enzymatic treatment for the residues
Authors: Gao Kuan , He Shudong , Li Qiuyang , Chen Haoshuang , Sun Hanju , Miao Xinya 
Published: August 2022

AbstractThe mild alkali extraction combined with the enzymatic hydrolysis was explored to extract protein from glutinous rice bran in the study, and the function properties of the proteins were investigated. The mild alkali extraction of pH 5.0 and temperature 50°C was carried out firstly for the water‐soluble protein extraction from the bran at the solid–liquid ratio of 1:10 (w/v) for 3.0 h, and the complex enzyme of cellulase and papain (7:3, w/w) were subsequently added to hydrolyze the residue for a better protein yield. After a mild proteolysis treatment under the conditions of enzyme addition 5.0%, pH 6.0, temperature 55°C and time 4.5 h, the final 90.2 ± 0.22% protein yield was obtained. It was interesting that the DPPH radical scavenging activity of the IC50 0.71 mg/ml was significantly improved, meanwhile, based on the combined extraction strategy, the protein solubility, emulsifying, and foaming properties were significantly enhanced in a wide range of pH environments. These results demonstrated that the mild alkali extraction combined with the enzymatic hydrolysis could be used in the glutinous rice bran protein extraction with high yield and good functionality, and the extracted protein could be potentially applied in food industry as nutraceutical ingredient or as the functional ingredient in the commercialized food products.Novelty impact statementAlthough the glutinous rice bran has an abundance of protein content, the protein has not been well extracted yet to be utilized in the food industry. Therefore, the proper procedure needs to be explored for glutinous rice bran protein extraction. The mild alkali combined with the enzymatic hydrolysis was firstly applied in the study, and the protein yield of glutinous rice bran protein was notably improved, furthermore, the antioxidant and function properties of glutinous rice bran protein also have been significantly increased because of the mild extraction and proteolysis.
Rare Disasters, Financial Development, and Sovereign Debt
Authors: REBELO SERGIO , WANG NENG , YANG JINQIANG 
Published: August 2022

ABSTRACTWe propose a model of sovereign debt in which countries vary in their level of financial development, defined as the extent to which they can issue debt denominated in domestic currency in international capital markets. We show that low levels of financial development generate the “debt intolerance” phenomenon that plagues emerging markets: it reduces overall debt capacity, increases credit spreads, and limits the country's ability to smooth consumption.
Influence of testing environment on consumer liking of doenjang stew
Authors: Hwang Jisun , Kim Mina K. 
Published: August 2022

AbstractCentral location test (CLT) is a more widely employed method for testing consumer acceptance in comparison to home usage test (HUT). In this study, the influence of the testing environment on the consumer liking of doenjang stew was determined. Consumer acceptance testing of doenjang stew was conducted four times, with one CLT and three HUTs. For HUTs, samples were served in different containers: 50 ml of premade doenjang stew in a plastic 95‐ml disposable cup, representing CLT conducted at home; 200 ml (one serving size) of premade doenjang stew in a 500‐ml plastic disposable bowl, representing restaurant “take out,” corresponded to the CLT condition performed at home; and doenjang stew meal kit including doenjang paste, vegetables, broth, and cooking recipe, representing meal‐kit consumption scenario. Differences in product liking were observed according to the testing environment (p < .05). In case of appearance‐related attributes (no tasting involved), consumers rated higher liking scores to doenjang stew evaluated under a meal‐kit HUT situation (p < .05). When tasting was involved, consumers rated higher scores to stew samples under the CLT condition (p < .05). The salinity of doenjang stew was the same under all of the product testing environments, while the salty taste liking was rated the highest under the CLT situation (p < .05). Results of this study suggested that the testing environment affects the consumer acceptance testing results.Practical ApplicationsThis study reported that differences in liking attributes under different testing environments, in that the highest overall liking score was rated under CLT condition, while HUT presented as “meal‐kit” received highest appearance‐related liking scores. Based on the results, this study suggests the consumer acceptance testing of doenjang stew using the CLT rather than the HUT considering the time and economics. This study provided an appropriate method to test the consumer liking of doenjang stew‐type food products, which can be utilized in future consumer‐related research.
Effect of calcifediol supplementation on renin‐angiotensin‐aldosterone system mediators in dogs with chronic kidney disease
Authors: Miller Matthew , Quimby Jessica , Langston Catherine , Ames Marisa , Parker Valerie J. 
Published: August 2022

AbstractBackgroundChronic kidney disease (CKD) leads to low serum concentrations of vitamin D metabolites. Thus, hypovitaminosis D associated with CKD might contribute to disease progression via increased concentration of renin angiotensin aldosterone system (RAAS) mediators.ObjectivesTo evaluate whether supplementation with calcifediol affects equilibrium concentrations of selected mediators of the RAAS. We hypothesized that vitamin D supplementation will decrease concentration of circulating RAAS mediators in dogs with CKD.AnimalsSix client‐owned adult dogs with IRIS Stage 2 and 3 CKD.MethodsProspective study. Serum 25‐hydroxyvitamin D (25[OH]D), 1,25‐dihydroxyvitamin D (1,25[OH]2D), 24,25‐dihydroxyvitamin D (24,25[OH]2D), RAAS mediators (angiotensin I/II/III/IV/1‐5/1‐7, and aldosterone), and surrogate angiotensin converting enzyme (ACE) activity (calculated by the ratio of angiotensin II to angiotensin I) were evaluated at baseline, after 3 months of calcifediol supplementation, and 2 months after discontinuing administration of supplement.ResultsAll serum vitamin D metabolite concentrations increased significantly by month 3 (P < .001): 25(OH)D (median 250 ng/mL; range, 204‐310), compared to baseline (median 43.2 ng/mL; range, 33.8‐58.3 ng/mL); 1,25(OH)2D (median 66.1 pg/mL; range, 57.3‐88.1 pg/mL) compared to baseline (median 35.2 pg/mL; range, 29.3‐56.7 pg/mL); 24,25(OH)2D (median 68.4 ng/mL; range, 22.1‐142.0 ng/mL) compared to baseline (median 14.4 ng/mL; range, 9.0‐21.3 ng/mL). Calculated ACE activity was significantly lower at month 3 (median 0.5; range, 0.4‐1.0) compared to baseline (median 0.7; range, 0.6‐1.3; P = .01). There were no significant differences in any of the evaluated RAAS variables at any other time‐point.Conclusions and Clinical ImportanceShort‐term calcifediol supplementation in this small group of CKD dogs appeared to decrease ACE activity.
Relevance of DNA preservation for future botany and ecology
Authors: González‐Toral Claudia , Cires Eduardo 
Published: August 2022

AbstractThe use of molecular methods in plant systematics and taxonomy has increased during the last decades; however, the accessibility of curated genetic samples and their metadata is a bottleneck for DNA‐based genetic studies in botany. Plant biodiversity DNA banks and DNA‐friendly collections could be critical suppliers of curated genetic material for researchers in the current context of plant biodiversity loss. Here, we aimed to understand the potential of plant DNA banks and DNA‐friendly collections to enhance the growth and openness of scientific knowledge. The preservation of genetic material should become part of a natural collection's process for the generation of extended specimens enabling the preservation of both the phenotype and genotype and contributing to the generation of data networks which cross‐fertilize other fields. These curated collections are advantageous in endangered species research, detecting processes related to extinction, giving a genetic dimension to IUCN assessments or completing the Leipzig Catalogue of Vascular Plants. Therefore, DNA collections are fundamental in producing FAIR data, responsible research and innovation (RRI) and meeting the goals of international conservation programmes. The completion of natural collections is important for current research efforts and furthermore vital to support future research in an era of ongoing plant biodiversity loss.
Genetic patterns in Montipora capitata across an environmental mosaic in Kāne'ohe Bay, O'ahu, Hawai'i
Authors: Caruso Carlo , Rocha de Souza Mariana , Ruiz‐Jones Lupita , Conetta Dennis , Hancock Joshua , Hobbs Callum , Hobbs Caroline , Kahkejian Valerie , Kitchen Rebecca , Marin Christian , Monismith Stephen , Madin Joshua , Gates Ruth , Drury Crawford 
Published: August 2022

AbstractSpatial genetic structure (SGS) is important to a population's ability to adapt to environmental change. For species that reproduce both sexually and asexually, the relative contribution of each reproductive mode has important ecological and evolutionary implications because asexual reproduction can have a strong effect on SGS. Reef‐building corals reproduce sexually, but many species also propagate asexually under certain conditions. To understand SGS and the relative importance of reproductive mode across environmental gradients, we evaluated genetic relatedness in almost 600 colonies of Montipora capitata across 30 environmentally characterized sites in Kāneʻohe Bay, Oʻahu, Hawaii, using low‐depth restriction digest‐associated sequencing. Clonal colonies were relatively rare overall but influenced SGS. Clones were located significantly closer to one another spatially than average colonies and were more frequent on sites where wave energy was relatively high, suggesting a strong role of mechanical breakage in their formation. Excluding clones, we found no evidence of isolation by distance within sites or across the bay. Several environmental characteristics were significant predictors of the underlying genetic variation (including degree heating weeks, time spent above 30°C, depth, sedimentation rate and wave height); however, they only explained 5% of this genetic variation. Our results show that asexual fragmentation contributes to the ecology of branching corals at local scales and that genetic diversity is maintained despite strong environmental gradients in a highly impacted ecosystem, suggesting potential for broad adaptation or acclimatization in this population.
Identification of a novel heterozygous DYSF variant in a large family with a dominantly‐inherited dysferlinopathy
Authors: Folland Chiara , Johnsen Russell , Botero Gomez Adriana , Trajanoski Daniel , Davis Mark R. , Moore Ursula , Straub Volker , Barresi Rita , Guglieri Michela , Hayhurst Hannah , Schaefer Andrew M. , Laing Nigel G. , Lamont Philipa J. , Ravenscroft Gianina 
Published: August 2022

AbstractAimsDysferlinopathy is an autosomal recessive muscular dystrophy, caused by bi‐allelic variants in the gene encoding dysferlin (DYSF). Onset typically occurs in the second to third decade and is characterised by slowly progressive skeletal muscle weakness and atrophy of the proximal and/or distal muscles of the four limbs. There are rare cases of symptomatic DYSF variant carriers. Here, we report a large family with a dominantly inherited hyperCKaemia and late‐onset muscular dystrophy.Methods and ResultsGenetic analysis identified a co‐segregating novel DYSF variant [NM_003494.4:c.6207del p.(Tyr2070Metfs*4)]. No secondary variants in DYSF or other dystrophy‐related genes were identified on whole genome sequencing and analysis of the proband's DNA. Skeletal muscle involvement was milder and later onset than typical dysferlinopathy presentations; these clinical signs manifested in four individuals, all between the fourth and sixth decades of life. All individuals heterozygous for the c.6207del variant had hyperCKaemia. Histological analysis of skeletal muscle biopsies across three generations showed clear dystrophic signs, including inflammatory infiltrates, regenerating myofibres, increased variability in myofibre size and internal nuclei. Muscle magnetic resonance imaging revealed fatty replacement of muscle in two individuals. Western blot and immunohistochemical analysis of muscle biopsy demonstrated consistent reduction of dysferlin staining. Allele‐specific quantitative PCR analysis of DYSF mRNA from patient muscle found that the variant, localised to the extreme C‐terminus of dysferlin, does not activate post‐transcriptional mRNA decay.ConclusionsWe propose that this inheritance pattern may be underappreciated and that other late‐onset muscular dystrophy cases with mono‐allelic DYSF variants, particularly C‐terminal premature truncation variants, may represent dominant forms of disease.
Autopolyploid inheritance and a heterozygous reciprocal translocation shape chromosome genetic behavior in tetraploid blueberry (Vaccinium corymbosum)
Authors: Mengist Molla F. , Bostan Hamed , De Paola Domenico , Teresi Scott J. , Platts Adrian E. , Cremona Gaetana , Qi Xinpeng , Mackey Ted , Bassil Nahla V. , Ashrafi Hamid , Giongo Lara , Jibran Rubina , Chagné David , Bianco Luca , Lila Mary A. , Rowland Lisa J. , Iovene Marina , Edger Patrick P. , Iorizzo Massimo 
Published: August 2022

Summary

Understanding chromosome recombination behavior in polyploidy species is key to advancing genetic discoveries. In blueberry, a tetraploid species, the line of evidences about its genetic behavior still remain poorly understood, owing to the inter‐specific, and inter‐ploidy admixture of its genome and lack of in depth genome‐wide inheritance and comparative structural studies.

Here we describe a new high‐quality, phased, chromosome‐scale genome of a diploid blueberry, clone W85. The genome was integrated with cytogenetics and high‐density, genetic maps representing six tetraploid blueberry cultivars, harboring different levels of wild genome admixture, to uncover recombination behavior and structural genome divergence across tetraploid and wild diploid species.

Analysis of chromosome inheritance and pairing demonstrated that tetraploid blueberry behaves as an autotetraploid with tetrasomic inheritance. Comparative analysis demonstrated the presence of a reciprocal, heterozygous, translocation spanning one homolog of chr‐6 and one of chr‐10 in the cultivar Draper. The translocation affects pairing and recombination of chromosomes 6 and 10. Besides the translocation detected in Draper, no other structural genomic divergences were detected across tetraploid cultivars and highly inter‐crossable wild diploid species.

These findings and resources will facilitate new genetic and comparative genomic studies in Vaccinium and the development of genomic assisted selection strategy for this crop.
Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
Authors: Brown Alistair J. P. 
Published: August 2022

AbstractWe are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to gain advantage during these skirmishes, the interactions between host and fungal pathogen are complex and dynamic. Nevertheless, simply compromising the physiological robustness of fungal pathogens reduces their ability to evade antifungal immunity, their virulence, and their tolerance against antifungal therapy. In this article I argue that this physiological robustness is based on a ‘Resilience Network’ which mechanistically links and controls fungal growth, metabolism, stress resistance and drug tolerance. The elasticity of this network probably underlies the phenotypic variability of fungal isolates and the heterogeneity of individual cells within clonal populations. Consequently, I suggest that the definition of the fungal Resilience Network represents an important goal for the future which offers the clear potential to reveal drug targets that compromise drug tolerance and synergise with current antifungal therapies.
Correlations between photosynthetic heat tolerance and leaf anatomy and climatic niche in Asian mangrove trees
Authors: Li X. , Wen Y. , Chen X. , Qie Y. , Cao K.‐F. , Wee A. K. S. 
Published: August 2022

Abstract
Photosynthetic heat tolerance (PHT) is a key predictor of plant response to climate change. Mangroves are an ecologically and economically important coastal plant community comprised of trees growing at their physiological limits. Mangroves are currently impacted by global warming, yet the PHT of mangrove trees is poorly understood.
In this study, we provide the first assessment of PHT in 13 Asian mangrove species, based on the critical temperature that causes the initial damage (TCrit) and the temperature that causes 50% damage (T50) to photosystem II. We tested the hypotheses that the PHT in mangroves is: (i) correlated with climatic niche and leaf traits, and (ii) higher than in plants from other tropical ecosystems.
Our results demonstrated correlations between PHT and multiple key climate variables, the palisade to spongy mesophyll ratio and the leaf area. The two most heat‐sensitive species were Kandelia obovata and Avicennia marina. Our study also revealed that mangrove trees show high heat tolerance compared to plants from other tropical ecosystems.
The high PHT of mangroves thus demonstrated a conservative evolutionary strategy in heat tolerance, and highlights the need for integrative and comparative studies on thermoregulatory traits and climatic niche in order to understand the physiological response of mangrove trees to climate change‐driven heatwaves and rising global temperatures.
Tilapia introduction in China: Economic boom in aquaculture versus ecological threats to ecosystems
Authors: Xiong Wen , Guo Chuanbo , Gozlan Rodolphe E. , Liu Jiashou 
Published: August 2022

AbstractThe introduction and use of non‐native species in aquaculture have played a central role in the development of this economic sector worldwide. Tilapia is one of the most widely introduced species in the world, and China has become the largest producer and consumer of tilapia. While non‐native tilapia in China support provisioning ecosystem services of substantial economic value, the invasion also poses potential threats to native fish diversity, ecosystems and ultimately the sustainable fisheries development. However, knowledge regarding the invading pathway, aquaculture development, economic benefits and the ecological impacts of such important non‐native species is still limited, especially in China. Based on thorough literature review as well as field surveys, this paper has comprehensively presented the introduction of tilapia species across a range of aquatic habitats and its role in the aquaculture industry growth, emphasising the economic benefits in China. In addition, we also synthesised the potential negative ecological impacts caused by tilapia invasion with global evidences, which will provide excellent lessons and management recommendations for China and other countries worldwide. Future trends tend to indicate an increase in the number and frequency of tilapia's introduction in China, with an increasing likelihood of environmental impacts. However, it is apparent that the aquaculture of non‐native tilapias is a highly profitable activity in China which makes the introductions inevitable, therefore, alternative management strategies and implications are further discussed to seek to achieve more sustainable and ecosystem‐friendly aquaculture, reduce the risks and negative impacts on ecosystems while still maintaining the economic benefits.
A model of police financing through income and consumption taxes
Authors: Deng Weiguang , Li Xue , Luo Zijun 
Published: August 2022

AbstractThis article studies police financing with a focus on the difference in the timing between federal and local government funds. In general, federal government funds came from income taxes collected before possible appropriative activities while local government funds came from consumption taxes collected afterwards. We find that income‐tax financing results in more workers, more police, and fewer thieves when appropriation and tax rates are the same between the two cases. Funding the police before possible appropriative activities works as a deterrence. Our findings show the complexity of studying crime and police financing even in a highly stylized model.