bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensemble of Phanom Rung, Mueang Tam and Plai Bat Sanctuaries and the Phimai Cultural Route: Comparative Study and Future Expectation in World Heritage Context
Authors: Poshyanandana Saowalux 
Published: June 2022

Abstract
The removal of “Phimai, its Cultural Route and the Associated Temples of Phanomroong and Muangtam” from the the World Heritage Tentative List in 2019 indicates the change of focus of the Thailand State Party away from this emsemble originally included as components of the Phimai cultural route. This paper discusses the reasons behind this change, the values and ouv as well as advantages and disadvantages of these two proposals in the context of World Heritage nomination. It concludes that the proposal of the Ensemble of Phanom Rung was made after work on nominating the Phimai cultural route faced management obstacles and disputes between the responsible organization and local people, rather than on the values of the cultural route itself. As for the ensemble, the main concern is that this serial cultural heritage site still requires extensive study to justify the proposed criteria. Therefore, the Phimai cultural route, with its advantages in strong and verifiable values, may be reconsidered for World Heritage nomination when management issues are resolved.
Association of socioeconomic status with nonsuicidal self-injury and suicidal ideation in young Korean adults
Authors: Park Heyeon , In Sunwoo , Hur Ji-Won 
Published: June 2022

Objective: Although nonsuicidal self-injury (NSSI) in youth is an important mental health concern worldwide, limited studies have investigated its sociodemographic correlates in early adulthood. This study explored associations between socioeconomic status (SES) and self-harm behaviors, including NSSI and suicidal ideation, in a community-based sample of young adults. Methods: A total of 414 Korean young adults engaged in NSSI and 200 controls completed online self-report questionnaires assessing sociodemographic and clinical characteristics, using logistic regression to estimate the odds ratio and analyzed risk factors for NSSI, especially the independent influence of SES on NSSI risk. Multivariate regression was performed to identify the role of socioeconomic disadvantage in suicidal ideation in NSSI people. Results: Logistic regression showed that low SES significantly increased NSSI risk. Multivariable regression also revealed that lower SES was related to more severe suicidal ideation in young adults with NSSI after controlling for gender and the higher-severity NSSI index, including the number of NSSI methods used and NSSI intrapersonal functions. Conclusions: This is the first study to directly address socioeconomic gradients of a general population of young adults with NSSI and its effects, and socioeconomic status should be considered preemptively when defining suicide risks of this group and when intervening in self-injurious behaviors.
COVID-19 Vaccination and Intent Among Pregnant Women, United States, April 2021
Authors: Razzaghi Hilda , Kahn Katherine E. , Masalovich Svetlana , Black Carla L. , Nguyen Kimberly H. , Barfield Wanda D. , Galang Romeo R. , Singleton James A. 
Published: June 2022

Objectives: National data on COVID-19 vaccination coverage among pregnant women are limited. We assessed COVID-19 vaccination coverage and intent, factors associated with COVID-19 vaccination, reasons for nonvaccination, and knowledge, attitudes, and beliefs related to COVID-19 illness and vaccination among pregnant women in the United States. Methods: Data from an opt-in internet panel survey of pregnant women conducted March 31–April 16, 2021, assessed receipt of ≥1 dose of any COVID-19 vaccine during pregnancy. The sample included 1516 women pregnant any time during December 1, 2020–April 16, 2021, who were not fully vaccinated before pregnancy. We used multivariable logistic regression to determine variables independently associated with receipt of COVID-19 vaccine. Results: As of April 16, 2021, 21.7% of pregnant women had received ≥1 dose of COVID-19 vaccine during pregnancy, 24.0% intended to receive a vaccine, 17.2% were unsure, and 37.1% did not intend to receive a vaccine. Pregnant women with (vs without) a health care provider recommendation (adjusted prevalence ratio [aPR] = 4.86), those who lived (vs not) with someone with a condition that could increase risk for serious medical complications of COVID-19 (aPR = 2.11), and those who had received (vs not) an influenza vaccination (aPR = 2.35) were more likely to receive a COVID-19 vaccine. Common reasons for nonvaccination included concerns about safety risk to baby (37.2%) or self (34.6%) and about rapid vaccine development (29.7%) and approval (30.9%). Conclusions: Our findings indicate a continued need to emphasize the benefits of COVID-19 vaccination during pregnancy and to widely disseminate the recommendations of the Centers for Disease Control and Prevention and other clinical professional societies for all pregnant women to be vaccinated.
A physical therapist–led clinical decision-making program reduced risk of adverse events after total knee arthroplasty over 3 years: A retrospective review
Authors: Peterson Seth 
Published: June 2022

Context Reducing adverse events after total knee arthroplasty has implications for newly developed bundled payment models. Objective To examine the impact of a physical therapist–led clinical decision-making program on the risk of adverse events, function, visits used, or reaching knee range of motion (ROM) goals in patients after total knee arthroplasty. Methods The decision-making program consisted of quarterly meetings and recommendations for early risk identification and evidence-based intervention. A retrospective review of electronic records included adult patients who underwent total knee arthroplasty postoperative rehabilitation in an 18-month baseline period from 2014 to 2015 and an intervention period from 2015 to 2018. Relative risk reduction (RRR) determined whether a reduction in risk had occurred. Discharge function was measured with the Lower Extremity Functional Scale. Results A total of 160 patients were included, 69 from the 18-month baseline period and 91 from the 36-month intervention period. Mean (SD) age was 68 (9.2) years in the baseline period and 72 (9.7) years in the intervention period. There was an 8.4% (95% CI, 1.1%–64.9%) RRR in adverse events. The RRR for patients not reaching full knee extension was 70.5% (95% CI, 33.4%–87.0%) and the RRR for patients not reaching 120° of knee flexion was 65.5% (95% CI, 5.4%–87.4%). There was significant improvement in the discharge function score ( P = 0.05), but not the number of visits used ( P = 0.29). Conclusion The physical therapist–led clinical decision-making program reduced the risk of adverse events after total knee arthroplasty. The risk of not reaching ROM goals by discharge was also substantially reduced.
Visually significant cataract and associated factors among older people attending a community ophthalmic service in central Gondar Zone, Northwest Ethiopia: a cross-sectional study
Authors: Tegegn Melkamu Temeselew , Assaye Aragaw Kegne , Belete Gizachew Tilahun , Munaw Minychil Bantihun 
Published: June 2022

Objective In this study, we aimed to determine the prevalence of visually significant cataract and associated factors among older people attending community ophthalmic services in the central Gondar Zone, Northwest Ethiopia. Methods We conducted a community outreach-based cross-sectional study among adults aged ≥40 years in the central Gondar Zone from 30 May to 15 June 2021. We used systematic random sampling to select study participants. Interviewer-administered questionnaires and ocular examinations were performed and the data recorded. We applied binary logistic regression to identify factors associated with visually significant cataract. Results A total of 821 participants were included, with median age 57 years. The prevalence of visually significant cataract was 29.1% (95% CI: 26.1–32.0). Age ≥80 years (adjusted odds ratio [AOR] = 16.9; 95% CI: 7.5–38.4), rural residence (AOR = 1.7; 95% CI: 1.02–2.7), unmarried status (AOR = 1.9; 95% CI: 1.2–3.2), illiteracy (AOR = 2.9; 95% CI: 1.4–6.1), unemployed status (AOR = 1.7; 95% CI: 1.1–2.7), and sunlight exposure ≥5 hours per day (AOR = 1.6; 95% CI: 1.04–2.4) were significantly associated with visually significant cataract. Conclusion In this study, visually significant cataract was found to be high, which requires immediate public health intervention.
Risk of Diagnosed Adolescent-Onset Non-Affective Psychotic Disorder by Migration Background in British Columbia: A Retrospective Cohort Study
Authors: Magee Carly , Oberle Eva , Guhn Martin , Gadermann Anne , Puyat Joseph H. 
Published: June 2022

Objective We recently found that the risk of diagnosed non-affective psychotic disorder between the ages of 13 and 19 was lower for immigrant adolescents compared to those without a personal or parental migration history in British Columbia (BC), Canada. In the current study, we further examined the risk for migrants compared to non-migrants by region of origin and immigrant generation (first vs. second), adjusting for several demographic factors and migration class. Methods Administrative data were used to construct a cohort of individuals born 1990–98 and residing in South-Western BC ( N = 193,400). Cases were identified by either one hospitalization or two outpatient physician visits with a primary diagnosis of a non-affective psychotic disorder. Poisson regression was used to estimate incidence rate ratios (IRR) of a diagnosed non-affective psychotic disorder by region of origin among first- and second-generation migrants compared to non-migrants, adjusting for sex, birth year, neighbourhood income and low family income. Results Risk of diagnosed non-affective psychotic disorder was lower among first-generation migrants from East Asia (IRR = 0.34[95% CI: 0.25–0.46]), South-Asia (IRR = 0.47[95% CI: 0.25–0.89]) and South-East Asia (IRR = 0.55[95% CI: 0.32–0.93]) and second-generation migrants from East Asia (IRR = 0.49[95% CI: 0.35–0.69]) and South Asia (IRR = 0.52[95% CI: 0.37–0.73]), compared to non-migrants. Adjusting for migration class attenuated but did not fully explain variation in risk by region among first-generation migrants. No groups exhibited a significantly elevated risk of the diagnosed non-affective psychotic disorder compared to non-migrants. Conclusion Findings from this study underline the complexity of the association between migration and psychotic disorders. Future research should investigate why certain groups of migrants are less likely to be diagnosed and whether there are specific sub-groups that face an elevated risk.
Effect of hexagonal stringer design on bulging factor and stress intensity factor of cracks in the skin of pressurized aircraft fuselage
Authors: Zayati Ahmed F , Lazghab Tarek , Soula Mohamed 
Published: June 2022

Aircraft structural fatigue is a serious issue. Untreated, it could lead to failure. Several aircraft accidents were caused by widespread fatigue damage. For cracks in the fuselage, the stress state is due to the bulging around the crack caused by applied internal pressure. This condition is characterized by a parameter called the bulging factor; it compares the stress intensity factor of a crack in curved shell to its counterpart in a plate. Bulging factor expressions are available for longitudinal and circumferential cracks but less for slanted cracks. The underlying structure that stiffens the skin of the fuselage has a direct impact on the stress intensity factor and the bulging factor of the crack. A hexagonal grid stiffening pattern has been shown to provide sufficient stiffening to the fuselage skin while using a lesser amount of material compared to the traditional orthogonal grid design. However, the response of this grid pattern in the presence of a cracked fuselage has not been studied. The current paper aims to estimate the effect of the hexagonal grid pattern on the bulging factor and stress intensity factor of cracks of various lengths and orientations in the skin of the fuselage. Results obtained are compared to the conventional orthogonal grid stiffening pattern of a fuselage structure. Several patterns were considered. Results show that cracks of different lengths and orientations in hexagonal grid stiffened panels had stress intensity factors and bulging factors that are comparable to the base case within a margin of 2%–8%.
Evaluation of the use of açaí seed residue as reinforcement in polymeric composite
Authors: de Melo Barbosa Andrezza , Machado dos Santos Gabrielle , Medeiros de Melo Gabriel Messias , Litaiff Hannah Alagoas , Martorano Lucieta Guerreiro , Giacon Virgínia Mansanares 
Published: June 2022

Açaí ( Euterpe oleracea Mart.) is an important economic source in the north region of Brazil for agro-industry. However, it generates a huge amount of seed residue as agro-waste. The aim of this study is to evaluate the performance of this residue as reinforcement in particleboards. The medium-density particleboards were manufactured according to the experimental design (22 + 1), considering the parameters with two factors: “Granulometry”, for different açaí seed sizes (2.38, 1.19, 0.29, 0.15 and 0.07 mm) and “%Resin”, for different resin weight fractions (10%, 12.5% and 15%), both applied in the manufacturing of the composites. Measurements for the Apparent Density Thickness Swelling and Water Absorption (WA) of the particleboards were performed. Mechanical properties of particleboards were analyzed through top and surface Screw Withdrawal and Internal Bonding test. In addition, the morphology of surface from particleboards was evaluated through Scanning Electron Microscopy The results of TS for 24 h, WA for 2 and 24 h, and IB showed that the particle size was a significant factor ( p < .05). These results established that the highest particle sizes provided lower percentages of absorption. The results of Screw Withdrawal did not achieve the requirements established by NBR 14810–2:2018 standard. Besides that, the results presented statistical difference, considering the particle size and the interaction between parameters (“%Resin” and “Granulometry”), which resulted in a p-value < .05. For the Internal Bonding test, the composite with highest particle size exhibited the best performance compared to the other ones.
A Systematic Review of Warfarin Use in Post-Bariatric Surgery Patients: Cases Compiled From a Literature Review
Authors: Patel Pooja H. , Ho Tiffany , Upadhyay Shreeya M. 
Published: June 2022

Objective The objective of this review was to provide dosing recommendations for percentage change in weekly warfarin dose and rates of thrombotic and bleeding events in patients requiring long-term warfarin therapy after bariatric surgery. Data Sources: A comprehensive literature search of PubMed (through April 5, 2021), Cochrane Library, and Google Scholar (through April 5, 2021) databases was completed using the keywords warfarin OR vitamin k antagonist AND bariatric surgery. Study selection and data extraction: Retrospective studies and matched-cohort studies evaluating preoperative and postoperative use of warfarin after bariatric surgery for obesity were considered. Weekly dose defined as sum of daily doses of warfarin for 7 consecutive days was a required outcome to be considered in this review. Patients were excluded from review if post-operative dosage change was not reported. Data synthesis Six studies were included with a total of 160 patients who met the criteria. A decrease in average warfarin dose was seen in all studies, with the largest decrease occurring at 1 month postsurgery followed by an upward trend toward baseline about 90 days postsurgery. While thrombotic events were observed in none of the patients, there was an increased risk of bleeding in patients, particularly in those who underwent roux-en-y gastric bypass (RYGB) surgery. Relevance to patient care and clinical practice The study provides a specific warfarin dosing titration regimen, as well as embolic and bleed risk in post-bariatric surgery population. Conclusions Clinicians may consider lowering warfarin weekly dose by about 25% immediately postsurgery, with doses approaching closer to baseline about 90 days postsurgery.
Students’ Inattention Symptoms and Psychological Need Satisfaction During the Secondary School Transition: The Protective Role of Teachers’ Involvement
Authors: Duchesne Stéphane , Plamondon André , Ratelle Catherine F. 
Published: June 2022

Objective: This study examined the prospective relationship from student inattention symptoms to changes in their psychological need satisfaction (PNS) during their transition to secondary school. In doing so, it has explored whether this temporal association was moderated by teachers’ involvement (TI). Method: A sample of 688 students (46% male; Mage = 11.82) followed in Grade 6 and Secondary 1 was selected from a stratified random list. Results: Inattention symptoms predicted a decrease in autonomy and competence need satisfaction, after adjusting for gender, anxiety, aggression, and PNS at baseline. In addition, TI in Secondary 1 attenuated the association between inattention and autonomy need satisfaction decline. TI also predicted a smaller decrease in competence need satisfaction, over and above the contribution of inattention. Conclusions: Results support the importance of TI in PNS of students who are struggling with inattention throughout a critical transition. Implications for educational practices and research are discussed.
An 8-Gene Signature for Classifying Major Subtypes of Non-Small-Cell Lung Cancer
Authors: Hamaneh Mehdi , Yu Yi-Kuo 
Published: June 2022

Motivation: The precise diagnosis of the major subtypes, lung adenocarcinoma and lung squamous cell carcinoma, of non-small-cell lung cancer is of practical importance as some treatments are subtype-specific. However, in some cases diagnosis via the commonly-used method, that is staining the specimen using immunohistochemical markers, may be challenging. Hence, having a computational method that complements the diagnosis is desirable. In this paper, we propose a gene signature for this purpose. Results: We developed an expression-based method that systematically suggests a huge set of candidate gene signatures and finds the best candidate. By applying this method to a training set, the optimal gene signature was found by considering close to 765 billion candidate signatures. The 8-gene signature found for classifying the 2 aforementioned subtypes comprises TP63, CALML3, KRT5, PKP1, TESC, SPINK1, C9orf152, and KRT7. The signature achieved a high overall prediction accuracy of 0.936 when tested using 34 independent gene expression datasets obtained using different technologies and comprising 2556 adenocarcinoma and 1630 squamous cell carcinoma samples. Additionally, the signature performed well in clinically challenging cases, that is poorly differentiated tumors and specimens obtained from biopsies. In comparison with 2 previously reported signatures, our signature performed better in terms of overall accuracy and especially accuracy of classifying lung squamous cell carcinoma. Conclusions: Our signature is easy to use and accurate regardless of the technology used to obtain the gene expression profiles. It performs well even in clinically challenging cases and thus can assist pathologists in diagnosis of the ambiguous cases.
Interleukin-33 and thymic stromal lymphopoietin are primary cytokines involved in the Th1/Th2 inflammatory response in chronic secretory otitis media
Authors: Liao Zhifang , Tu Bo , Sun Liang , Dong Chang , Jiang Hongyan , Hu Genwen 
Published: June 2022

Background: T-helper (Th)1/Th2 inflammatory responses are responsible for secretory otitis media (SOM) development. However, the mechanisms underlying these immune responses remain unknown. This study aims to identify the primary cytokines that play essential roles in chronic SOM. Methods: Two groups were established for the present study: chronic SOM group ( n = 21) and control group ( n = 10). The middle ear effusion and serum samples of the expression cytokines (interleukin IL-2, IL-4, IL-5, IL-13, IL-17, IL-25, IL-33, interferon [IFN]-γ, thymic stromal lymphopoietin [TSLP], immunoglobulin IgE, and pepsins) were analyzed by enzyme-linked immunosorbent assay. Results: The levels of IL-4, IL-5, IL-13, IL-17, IL-25, IFN-γ, TLSP, pepsins, IL-2, and IL-33 (all, p < 0.001) were higher in middle ear effusion, when compared to those in serum, in chronic SOM group (non-paired sample). However, there was no significant difference in serum expression for those cytokines compared chronic SOM group and control group. The paired sample expression for IL-33 and TLSP (both, p = 0.046) were higher compared the effusion and serum in chronic SOM group. Conclusions: IL-33 produces inflammatory cytokines, such as IL-1b, IL-6, TNF-α, IL-10, IL-4, and TGF-β, which through nucleus into cytoplasm causing inflammatory responses. The present study revealed that IL-33 also produce IL-17, IL-4, IL-5, and IL-13 inflammatory factors, triggering an inflammatory response. Study reported that the combined stimulation of TSLP and IL-33 elicits an approximately 10-fold increase in cytokine production, when compared to the stimulation of IL-33 alone. This suggests that IL-33 and TLSP may be the primary cytokines involved in Th1/Th2 inflammatory responses in chronic SOM.
Impact of proton pump inhibitors on the in-hospital outcome of COVID-19 patients: a retrospective study
Authors: Yao Haijuan , Li Hongyu , Ma Zhuang , Wu Yanyan , Tang Yufu , Meng Hao , Yu Hao , Peng Chengfei , Teng Yue , Zhang Quanyu , Zhu Tianyi , Zhao Haitao , Chu Guiyang , Tong Zhenhua , Liu Lu , Lu Hui , Qi Xingshun 
Published: June 2022

Background: Coronavirus disease 2019 (COVID-19) has triggered a global public health crisis. Proton pump inhibitors (PPIs) are one of the most commonly prescribed drugs. However, the effect of PPIs on the clinical outcomes of COVID-19 patients remains unclear. Methods: All COVID-19 patients admitted to the Wuhan Huoshenshan Hospital from February 2020 to April 2020 were retrospectively collected. Patients were divided into PPIs and non-PPIs groups. Logistic regression analyses were performed to explore the effects of PPIs on the outcomes of COVID-19 patients, including transfer to intensive care unit, mechanical ventilation, and death. Subgroup analyses were performed according to the presence of upper gastrointestinal symptoms potentially associated with acid and the routes, types, median total dosage, and duration of PPIs. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: Of the 3024 COVID-19 patients included, 694 and 2330 were in PPIs and non-PPIs groups, respectively. Univariate logistic regression analysis showed that PPIs significantly increased the risk of reaching the composite endpoint in COVID-19 patients (OR = 10.23, 95% CI = 6.90–15.16, p < 0.001). After adjusting for age, sex, comorbidities, other medications, and severe/critical COVID-19, PPIs were independently associated with an increased risk of reaching the composite endpoint (OR = 7.00, 95% CI = 4.57–10.71, p < 0.001). This association remained significant in patients with upper gastrointestinal symptoms and those who received an intravenous omeprazole alone, but not those who received oral lansoprazole or rabeprazole alone. It was not influenced by dosage or duration of PPIs. Conclusion: The use of intravenous PPIs alone during hospitalization may be associated with worse clinical outcome in COVID-19 patients.