bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of matrix metalloproteinases in the development of diabetic retinopathy in the elderly
Authors: Фабрикантов О. Л. , Лев И.В. , Агарков Н.М. , Османов Р.Э. 
Published: August 2022

Развитие диабетической ретинопатии ассоциируется с матриксными металлопротеиназами, но они редко применяются для прогнозирования данной патологии. Цель исследования -прогнозирование развития непролиферативной диабетической ретинопатии в пожилом возрасте по уровню матриксных металлопротеиназ в плазме крови. Основную группу составили 63 пациента 60- 74 лет с сахарным диабетом 2-го типа и непролиферативной диабетической ретинопатией, контрольную - 56 пациентов такого же возраста с сахарным диабетом 2-го типа и отсутствием диабетической ретинопатии и другой офтальмопатологии в настоящее время и в анамнезе. Обследование пациентов обеих групп включало тонометрию, визиометрию, стандартную фоторегистрацию глазного дна, оптическую когерентную томографию, оптическую когерентную томографию-А, флюоресцентную ангиографию. Определение матриксных металлопротеиназ осуществляли методом твердофазного ИФА. Установлено статистически значимое повышение уровня матриксной металлопротеиназы-9 в основной группе больных до 55,7±2,6 нг/мл против 40,2±1,9 нг/мл в контрольной, матриксной металлопротеиназы-2 до 269,8±4,2 нг/мл против 221,9±3,6 нг/ мл соответственно. На основе уровня матриксных металлопротеиназ-2 (Х) и -9 (Х) в крови создана регрессионная модель для прогнозирования развития диабетической ретинопатии, имеющая вид Y=28,315+3,892·X+2,453·X, что позволит выявлять заболевание на ранней стадии.
The development of diabetic retinopathy is associated with matrix metalloproteinases, but they are rarely used to predict this pathology. The aim of the study was to predict the development of non-proliferative diabetic retinopathy in old age by the level of matrix metalloproteinases in blood plasma. The main study group consisted of 63 patients aged 60-74 years with type 2 diabetes mellitus and non-proliferative diabetic retinopathy, the control was 56 patients of the same age with type 2 diabetes mellitus and the absence of diabetic retinopathy and other ophthalmopathology at present and in the anamnesis. Examination of patients of both groups included: tonometry, visiometry, standard fundus photoregistration, optical coherence tomography, optical coherence tomography-A, fluorescent angiography. Determination of matrix metalloproteinases was carried out by the method of solid-phase enzyme immunoassay. There was a statistically significant increase in matrix metalloproteinase-9 in the main group of patients to 55,7±2,6 ng/ml versus 40,2±1,9 ng/ml in the age control, matrix metalloproteinase-2 to 269,8±4,2 ng/ml versus 221,9±3,6 ng/ml, respectively. Based on the level of matrix metalloproteinases-2 (X) and -9 (X) in the blood, a regression model was created by the regression method to predict the development of diabetic retinopathy, having the form Y=28,315+3,892·X+2,453·X, which will allow detecting the disease at an early stage.
The state of the oral cavity in early diagnosis and predicting cognitive disorders
Authors: Мякотных В.С. , Сиденкова А.П. , Харитонова М.П. , Мещанинов В.Н. , Мельник А.А. , Хилюк Д.А. 
Published: August 2022

Представлен обзор литературы по проблеме использования неинвазивных технологий в ранней диагностике и прогнозировании возраст-ассоциированного когнитивного снижения, связанного в своей основе с болезнью Альцгеймера. Основное внимание уделяется исследованию состояния буккального эпителия и ротовой жидкости как суррогатных моделей дегенеративного поражения церебральных структур, а также определению роли микроорганизмов ротовой полости в формировании и развитии когнитивных нарушений. Приводится оригинальная гипотеза нейродегенеративного поражения церебральных структур, на основе которой предлагается алгоритм исследований состояния полости рта для наиболее раннего выявления и прогноза когнитивного дефицита.
A review of the literature on the problem of the use of non-invasive technologies in early diagnosis and prediction of age-associated cognitive decline associated with Alzheimer’s disease is presented. The main attention is paid to the study of the buccal epithelium, oral fluid, as surrogate models of degenerative lesions of cerebral structures, as well as determining the role of oral microorganisms in the formation and development of cognitive disorders. An original hypothesis of neurodegenerative lesions of cerebral structures is presented, on the basis of which an algorithm for studying the state of the oral cavity is proposed in order to detect and predict cognitive deficits as early as possible.
Optimization of rehabilitation of elderly and senile patients with primary traumatic dislocation of the shoulder
Authors: Асланов В.А. , Линник С.А. , Пономаренко Г.Н. , Гуманенко Е.К. , Кучеев И.О. , Слабоспицкий М.А. , Ромашов П.П. , Штанько В.А. , Лузанов А.А. , Ковальчук Г. Л. 
Published: August 2022

Цель исследования - улучшение исходов лечения пациентов пожилого возраста с первичным травматическим вывихом плеча путем разработки атравматичного способа реабилитации. В исследование вошли 56 пациентов старше 60 лет с первичным травматическим вывихом плеча. В анамнезе до настоящего вывиха травм поврежденного плечевого сустава не было. Все больные были разделены на две группы в зависимости от тактики применяемого лечения. Пациентам 1-й группы (29 больных) после вправления вывиха плеча производили функциональное лечение с помощью ортезов и разработанного курса лечебной физкультуры. Больным 2-й группы (27 больных) лечение осуществляли по традиционной методике с применением гипсовой иммобилизации после вправления вывиха плеча. Для диагностики вывиха плеча и оценки исходов выполняли рентгенографию плечевого сустава, МРТ, определение потенциалов в биологически активных точках в течение первых 2-3 сут после вывиха. Для оценки ближайших результатов изучали электропотенциал в биологически активных точках через 1, 3 и 6 мес. У 70,3 % больных 1-й группы через 3-6 мес по шкале ASES получены положительные исходы, в то время как во 2-й группе такие результаты достигнуты только у 57,3 % пациентов, а по шкале UCLA - 22,8 и 19,2 % соответственно. Таким образом, использование предложенной тактики функционального лечения позволяет достоверно ( p <0,05) улучшить исходы у пациентов старшей возрастной группы.
Тhe aim of the study is to improve the treatment outcomes of elderly patients with primary traumatic shoulder dislocation by developing an atraumatic rehabilitation method. The study included 56 patients aged over 60 years with primary traumatic dislocation of the shoulder. The patients of the first group (29 patients) after the dislocation of the shoulder was corrected, functional treatment was performed using orthoses and a developed course of physical therapy. Patients of the second group (27 patients) were treated according to the traditional method with the use of plaster immobilization after the dislocation of the shoulder was corrected. Shoulder joint radiography, MRI, determination of potentials in biologically active points (BAT) during the first 2-3 days after dislocation were used to diagnose shoulder dislocation and assess outcomes. To assess the immediate results, the electrical potential in BAHT was studied after 1,3 and 6 months. In 70,3 % of group 1 patients, positive outcomes were obtained after 3-6 months on the ASES scale, while in the second group such results were achieved only in 57,3 % of patients, and on the UCLA scale 22,8 and 19,2 %, respectively. Thus, the use of the proposed tactics of functional treatment makes it possible to significantly ( p <0,05) improve outcomes in patients of the older age group.
Physical rehabilitation for osteochondrosis of the cervical and thoracic spine in elderly and senile people (Stage 3)
Authors: Бобунов Д.Н. , Тюсенко А.Е. , Темнякова В.А. , Солдатова Л.Н. , Иорданишвили А.К. , Проценко А.Р. 
Published: August 2022

Концепция мультидисциплинарного подхода к лечению остеохондроза у лиц пожилого и старческого возраста специалистами различного профиля медикаментозными и немедикаментозными методами на сегодняшний день особенно актуальна. Требуется разработка и внедрение в практику различных вариантов сочетанного применения средств физической реабилитации на разных этапах восстановительного лечения пациентов пожилого и старческого возраста с данной патологией. Динамика клинических проявлений остеохондроза после восстановительного лечения относительно возраста пациентов в группах показала, что эффективность методики значительно выше у пациентов пожилого возраста в отличие от пациентов старческого возраста и долгожителей. В ходе исследования не выявлено значимых осложнений и побочных эффектов при использовании данной методики, что позволяет рекомендовать ее как средство вторичной профилактики заболеваний шейного и грудного остеохондроза, особенно при противопоказаниях к применению нестероидных противовоспалительных препаратов и глюкокортикостероидов. Методика может быть рекомендована для использования в фитнес-клубах, атлетических залах и врачебно-физкультурных диспансерах.
The concept of a multidisciplinary approach to the treatment of osteochondrosis in elderly and senile patients by specialists of various profiles using medicinal and non-medicinal methods is especially relevant today, therefore, it is necessary to develop and put into practice various options for the combined use of physical rehabilitation means at different stages of rehabilitation treatment of elderly and senile patients with osteochondrosis of the cervical and thoracic spine. The dynamics of clinical manifestations of osteochondrosis after rehabilitation treatment relative to the age of patients in groups showed that the effectiveness of the technique is much higher in elderly patients, in contrast to senile patients and centenarians. The study revealed no significant complications and side effects when using this technique, which allows us to recommend it as a means of secondary prevention of diseases of the cervical and thoracic osteochondrosis, especially in the presence of contraindications to the use of non-steroidal anti-inflammatory drugs and glucocorticoids. The technique can be recommended for use in fitness clubs, athletic halls and medical and physical education dispensaries.
THE FINANCIAL PERFORMANCE IN THE INDONESIAN BANKING INDUSTRY REVIEW FROM GOOD CORPORATE GOVERNANCE AND INTELLECTUAL CAPITAL
Authors: Ulya Sinta Zahrotul , Puspitasari Elen 
Published: August 2022

This study aims to determine the effect of Good Corporate Governance and Intellectual Capital on the financial performance of Indonesian banking companies. Good Corporate Governance in terms of Board of Directors, Audit Committee, and Independent Commissioners. Intellectual capital measured by the efficiencies of human capital, structural capital, relational capital and capital employed. The population of this study is all banking companies listed on the Indonesia Stock Exchange for the 2017-2020. The number of samples from using purposive sampling technique obtained were 28 companies with 112 data observations. The major of financial performance proxied by Return on Assets and Capital Adequacy Ratio. This research uses multiple linear analysis method. The results of this study indicate that the Board of Directors and the efficiency of Human Capital, Structural Capital, Relational Capital, and capital employed have a significant positive effect on financial performances. Meanwhile, the Audit Committee and Independent Commissioner have no significant effect on financial performances.
THE EFFECT OF INSTITUTIONAL OWNERSHIP, COMPANY SIZE AND ASSET MANAGEMENT ON FIRM VALUE
Authors: Holly Anthony , Jao Robert , Mardiana Ana 
Published: August 2022

The study purpose is to investigate the impact of institutional ownership, firm size, and asset management to firm value. Sample of this research is companies listed in Indonesia Stock Exchange between 2016-2018. Sample selected by purposive sampling method. Data type used in this study is quantitative data and analyzed using multiple regression analysis to analysis dependent variable, firm value and independent variable, institutional ownership, firm size, and asset management. The result of the research revealed institutional ownership and firm size have positive and significant effect to firm value because the mechanism of control by institutions is more effective and the bigger of the companies means their manager can accumulate value. Asset management has no effect to firm value.
“I SHOULD LOVE LOCAL PRODUCT” : LOCAL PRODUCT LOYALTY WITHIN UTILITARIAN PERSPECTIVE
Authors: Wangsa Ignasius Heri Satrya , Tyra Maria Josephine 
Published: August 2022

Social aspect in consumer behavior has placed the essence of interaction between consumer and his environment. It is within the interactive process that consumer begins to recognize his role. Therefore, there are two domains in the context of local product loyalty. First, pressure of social function directs the consumption to satisfy certain level of social consequences ie. the deployment of loyalty as part of patriotism “I should love local product”. Second, economic rationality is always trying to seek the best combination in which resources can be allocated efficiently. In the first domain the discussion is mainly about local product consumption ie. nationalism-based consumption, while in the second one the utilitarian perspective is introduced as complement in the discourse of the rationales behind local product consumption. Participants in this research were selected and their narratives of local product consumption were analyzed through mixed-method approach. Marketing implication was also discussed to contribute in the theory of local product consumption within utilitarian perspective.
Fibrilación auricular no valvular en pacientes anticoagulados
Authors: Gil Aldana Victor José , Jiménez Lizcano Adriana Milena , Suárez Ramírez Omar Fabián , Vera Léon Cristian Camilo , Torres-Dimas Alejandro Esteban 
Published: August 2022

Objetivo: analizar las características epidemiológicas y clínicas de una población con fibrilación auricular no valvular (FANV) tratada con anticoagulación oral en el Instituto Cardiovascular del Tolima (Ibagué, Colombia).
Marco de referencia: la FANV es una patología prevalente en pacientes colombianos mayores de 60 años, quienes tienen mayor riesgo de accidente cerebrovascular, el cual es prevenible con el tratamiento de anticoagulación; sin embargo, a pesar de la terapia se pueden presentar complicaciones propias de la patología o secundarias a él.
Metodología: estudio de corte transversal, que describe las características basales de un total de 146 participantes con FANV en manejo con anticoagulantes orales, con seguimiento a través del registro de su historia clínica entre 2018 y 2019.
Resultados: de los participantes, el 53% corresponde a mujeres, el 57% de los participantes presentaron FANV tipo permanente siendo la más frecuente en la cohorte estudiada; recibieron manejo en 99% con anticoagulante oral no antagonista de la vitamina K (NOAC) (76% con rivaroxabán) y 1% con AVK (warfarina). El 89% de los participantes tuvo una clasificación dentro de CHADS2 de 1-3 y 87% dentro de HASBLED de 1-3; de estos, el 95% no presentó ACV/AIT, el 99% no presentó embolismo sistémico y 97% no presentó sangrados mayores, respectivamente con cada clasificación. No se documentaron eventos fatales para el 100% de los pacientes.
Conclusiones: se confirma asociación para las clasificaciones de tipo CHADS2, CHADS- 2VASC2, HASBLED y el desarrollo de ACV/AIT y hemorragias en la población estudiada (p<0.05).
Síndrome de Kounis perioperatorio en una adulta mayor: reporte de caso.
Authors: Castañeda-Camacho Hector Andrés , Mendoza-Pérez Andrea Carolina , Pinzón-Rodríguez Martha Carolina , Reyes Sonia Elizabeth , Salazar-Reyes Andrés Yobany , Vargas Rodriguez Ledmar Jovanny 
Published: August 2022

Introducción: El síndrome de Kounis (SDK) corresponde a una isquemia miocárdica secundaria a la liberación de mediadores inflamatorios (degranulación de mastocitos) durante una reacción alérgica. La anafilaxia en adultos comúnmente es desencadenada por medicamentos, de los cuales los antibióticos son los más frecuentemente informados. Objetivo: Estudiar la forma de presentación y abordaje clínico de un paciente con síndrome de Kounis y aumentar la sospecha diagnostica de una patología que no tiene un tratamiento estandarizado o respaldado por guías de práctica clínica. Presentación de caso: Se presenta el caso de una paciente adulta de 62 años con dolor precordial y equivalentes anginosos posterior a un choque anafiláctico perioperatorio durante una colecistectomía abierta realizada de forma programada por Colelitiasis, con posterior infarto agudo de miocardio sin elevación del ST, con arteriografía que descarto lesiones en arterias coronarias o enfermedad ateromatosa. Conclusión: El síndrome de kounis es una entidad subdiagnosticada, con presentación clínica variable y sin un tratamiento concreto o estandarizado, lo que motiva a realizar una mayor casuística y estructurar recomendaciones de amplia difusión respecto a su tratamiento.
Uji Daya Hambat Daun Ketepeng Cina terhadap Pertumbuhan Malassezia furfur Penyebab Tinea versicolor
Authors: Dirga Ayusti , Rahman Indas Wari , Yunasdy Muh. 
Published: August 2022

Tinea versicolor merupakan infeksi jamur yang terdapat pada permukaan kulit, penyakit ini disebabkan oleh jamur Malasezzia furfur. Penyakit merupakan infeksi jamur superfisial yang ditandai dengan munculnya makula di permukaan kulit, skuama halus, dan disertai rasa gatal pada kulit. Tujuan penelitian ini untuk mengetahui zona hambat dan menentukan konsentrasi KHM ekstrak daun ketepeng cina (Cassia alata. L) dalam menghambat pertumbuhan jamur Malassezia furfur. Penelitian ini termasuk penelitian eksprimen bersifat deskriftif .Metode yang digunakan yaitu metode Kirby Bauer. Kemudian data yang dianalisis dan disimpulkan. Hasil penelitian ini menunjukkan ekstrak daun ketepeng cina (Cassia alata. L) pada kosentrasi 20%, 40%, dan 60% menunjukkan adanya zona hambat didapatkan nilai rata-rata zona hambat kosentrasi 4.6 mm, 8,2 mm 10,23 mm. Kesimpulan dari 3 kosentasi 20%, 40%, dan 60% dengan nilai rata-rata zona hambat 4.6 mm, 8,2 mm, 10,23 mm dan kontrol positif 13,9 mm sedangkan zona hambat KHM adalah 20%
Pengaruh Kemampuan Koneksi Matematis dan Kebiasaan Belajar terhadap Hasil Belajar Matematika Siswa Kelas IX
Authors: A Siti Amirah , Mahmud Nurfadilah , Aprisal Aprisal 
Published: August 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh kemampuan koneksi matematis dan kebiasaan belajar terhadap hasil belajar matematika siswa kelas IX SMP Negeri 3 Tinambung. Penelitian ini adalah penelitian ex-post facto yang bersifat kausal komparatif dengan sampel penelitian sebanyak 87 siswa yaitu kelas IX SMP Negeri 3 Tinambung yang dipilih dengan menggunakan teknik sampling jenuh. Teknik pengumpulan data menggunakan instrumen: (1) tes kemampuan koneksi matematis, (2) angket kebiasaan belajar, dan (3) tes hasil belajar matematika. Analisis data dengan menggunakan statistik deskriptif dan analisis inferensial. Hasil pengujian deskriptif data menunjukkan bahwa: (1) kemampuan koneksi matematis berada pada kategori kurang. (2) kebiasaan belajar berada pada kategori sedang, dan (3) hasil belajar matematika siswa berada pada kategori sedang. Adapun hipotesis dalam penelitian ini ada 3 dengan hasil pegujian menggunakan analisis regresi berganda, yaitu: (1) kemampuan koneksi matematis tidak berpengaruh terhadap hasil belajar matematika siswa, (2) kebiasaan belajar berpengaruh terhadap hasil belajar matematika siswa, (3) kemampuan koneksi matematis dan kebiasaan belajar secara bersama-sama berpengaruh terhadap hasil belajar matematika siswa.
Istifham dalam Surah Al-Qiyamah: Suatu Kajian Kebahasaan
Authors: Maulana Muhamad Erpian 
Published: August 2022

Tujuan dari tulisan ini adalah untuk mengkaji istifham dalam surah al-Qiyamah. Keindahan bahasa Al-Qur’an lahir sebagai tantangan kepada orang Arab ketika itu untuk menandinginya. Ilmu balaghah sebagai salah satu disiplin ilmu yang mengkaji keindahan bahasa, di dalamnya membahas tentang istifham, yaitu pertanyaan yang termasuk pada kajian kalam insha’i. Metode penelitian yang digunakan adalah metode penelitian kualitatif, dengan jenis data berupa studi kepustakaan. Data analisis yang digunakan adalah deskriptif-analisis. Penulis menemukan bahwa terdapat enam jenis istifham dalam surah al-Qiyamah. Di antaranya dengan huruf hamzah yang berfungsi untuk membenarkan dengan jumlah empat, Aina yang merujuk pada pertanyaan tempat dengan jumlah satu dan kata Ayyana yang merujuk pada sesuatu yang dahsyat dan bersifat akan datang dengan jumlah satu. Istifham dengan hamzah pada surah ini telah keluar dari makna asalnya, karena indikasi dan konteks lain yang menuntut melahirkan makna yang berbeda.
Sistem Pendidikan Islam Menurut Pandangan Ideal Ibnu Khaldun:
Authors: Zubair Nur Fahimah , Syafi'i Imam 
Published: August 2022

This article aims to reveal how Ibn Khaldun thinks about education, which indirectly gives an idea of the ideal Islamic education system according to him. Not only that, the researcher will try to describe how much his thoughts have implications for the current style of Islamic education in Indonesia. The method used in this article is descriptive qualitative analysis, through a literature study of previous research documents and texts, it was found that the ideal education system according to Ibn Khaldun has enormous implications for the current style of Islamic education, as can be seen from his thoughts on the original language, curriculum, educator criteria, and other things that have a lot of conformity with the implementation and the Islamic Education Law in Indonesia.

Keywords: Education System, Ibn Khaldun, Islamic Education Thought, Implication
Harmonisasi Pendidikan Islam dan Negara
Authors: Zaman Mohamad Badrun , Nawir Muhammd Syukri , Islamy Athoillah , Aninnas Afina 
Published: August 2022

Citra baik Pesantren sebagai lembaga pendidikan Islam di Indonesia terkadang mmendapat stigma buruk akibat tindakan negatif oleh oknum-oknum yang hidup di lingkungan Pesantren itu sendiri. Merespons fenomena tersebut, maka membumikan nilai-nilai luhur sosial budaya bangsa Indonesia di lingkungan Pesantren menjadi hal yang sangat dibutuhkan. Penelitian kualitataif ini bertujuan untuk mengidentifikasi dimensi nilai Pancasila dalam orientasi penyelenggaraan pendidikan Pesantren yang termaktub pada Undang-undang No.18 Tahun 2019 tentang Pesantren. Penelitian normatif filosofis ini menggunakan nilai-nilai falsafah Pancasila sebagai teori analisis. Hasil penelitian menunjukan terdapat dimensi nilai-nilai Pancasila pada orientasi penyelenggaraan pendidikan Pesantren di Indonesia. Pertama, nilai sila kesatu dan kedua dalam orientasi pembentukan karakter individu yang religius dan humanis. Kedua, nilai sila ketiga dalam pembentukan karakter individu yang nasionalis dan pluralis. Ketiga, nilai sila keempat dan kelima dalam pembentukan karakter individu yang inovatif dan sejahtera. Implikasi teoritik penelitian ini menunjukan pendidikan Islam memiliki titik temu dengan pelbagai nilai universal yang dapat dimanifestasikan dalam kehidupan masyarakat plural. Keterbatasan penelitian ini belum menyentuh terkait bagaimana strategi pemerintah Indonesia terkait diseminasi nilai-nilai Pancasila dalam lembaga pendidikan Pesantren di Indonesia