bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of sleep-related hypoventilation in patients with pleuroparenchymal fibroelastosis
Authors: Yabuuchi Yuki , Saito Takefumi , Hirano Hitomi , Nonaka Mizu , Arai Naoki , Hyodo Kentaro , Kanazawa Jun , Miura Yukiko , Usui Shingo , Tamura Katsumi , Kasamatsu Tomotaka , Oh-ishi Shuji , Hayashihara Kenji , Matsuyama Masashi , Hizawa Nobuyuki 
Published: May 2022

Abstract
Background Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrosing lung disease with a predilection for the upper lobe and its progression causes hypoventilation, resulting in hypercapnia. Even though the association between sleep-related hypoventilation (SRH) and chronic obstructive pulmonary disease was well documented, its impact in patients with PPFE was not evaluated. The aim of this study is to clarify the impact of SRH on prognosis in PPFE.MethodsA retrospective review of the medical records of 52 patients with PPFE who underwent transcutaneous carbon dioxide monitoring during sleep was done. Patients were stratified into SRH (n=28) and non-SRH (n=24) groups based on American Academy of Sleep Medicine criteria. The impact of SRH on the prognosis of PPFE, as well as the clinical factors and comorbidities of PPFE associated with SRH, were evaluated. ResultsForced expiratory volume in the first second (FEV1), forced vital capacity (FVC), total lung capacity (TLC), and carbon monoxide diffusing capacity (DLco) in the SRH group were significantly lower than the non-SRH group (P< .01). Chronic pulmonary aspergillosis (CPA) was found at a higher rate in the SRH group (P= .02). The median survival time for SRH patients was 330 days, whereas roughly 80% of non-SRH patients were alive during the 3-year observation period (P< .01). Body mass index was a significant prognostic factor in PPFE patients with SRH (HR .78; 95% CI; .64-.94; P< .01). Home oxygen therapy (HOT) during the day and noninvasive positive pressure ventilation (NPPV) at night while sleeping tended to improve prognosis in the SRH group, as indicated by HR of .25 (P= .07).ConclusionsSRH may be a poor prognostic factor for PPFE. Additionally, SRH may modify susceptibility to Aspergillosis in patients with PPFE. HOT plus NPPV may improve the disease outcomes in patients with SRH.
Whole genome sequencing of Streptomyces antnestii sp. nov. with a potency to become an industrial strain
Authors: Chhettri Saroja , Sevigny Joseph , Pesce Céline , Sarkar Indrani , Thomas W. Kelley , Nouioui Imen , Sen Gargi , Tisa Louis S. , Sen Arnab 
Published: May 2022

Abstract
Strain San01, isolated from an ant-nest found in the tea estate of Darjeeling, India, was the subject of polyphasic taxonomic studies. Phylogenetic studies based on multilocus sequence analysis (atpK, gyrA, ftsZ, dnaKand secA) showed that isolate San01 forms a separate branch within the genus Streptomyces with Streptomyces avermitilis MA-4680T (ATTC 31267T=NCIMB 12804T=NRRL 8165T) as the closest neighbour. The average nucleotide identity (ANI) value (83.52%) between the genome sequence of the studied strain and its closest phylogenetic neighbour is below the threshold for assigning prokaryotic strain to a novel species. Strain San01 could also be distinguished from its closest neighbour using a broad range of phenotypic data. The draft genome sequence of isolate San01(NZ_RZYA00000000.1) was estimated to be 9.12 Mbp in size with 71.2% of GC content and it encompasses 39 biosynthetic gene clusters that emphasizes the biotechnological potential of this isolate. Based on the phenotypic, genetic and genomic data, isolate San01 (=JCM 34633 = NCTC 14543) merits to be recognized as a type strain of a novel species and hereby propose the name Streptomyces antnestiisp.nov. Incidentally, this is the first report on Streptomyces genomes from Darjeeling, India.
Comparison of treatment modalities as a bridge to curative surgery for malignant right-sided colonic obstruction: stent versus stoma
Authors: Park Yong Eun , Hong Seung Min , Lee Seung Bum , Lee Hong Sub , Baek Dong Hoon , Cha Rari , Lee Jong Yoon , Kim Tae Oh , Lee Jong Hoon 
Published: May 2022

Abstract
Background: The optimal treatment for acute malignant right-sided colonic obstruction (RSCO) remains challenging. Emergency resection, the traditional modality for RSCO, has shown significantly high mortality and morbidity rates according to recent studies. Initial bowel decompression by stent placement or stoma creation has been established for distal colonic obstruction. This study aimed to compare the clinical outcomes of these two procedures as a bridge to curative surgery for RSCO.Methods: This retrospective cohort study included 85 patients (46 men, mean age: 73 ± 16 years) who underwent loop ileostomy or endoscopic placement of a self-expanding metallic stent (SEMS) for RSCO at six referral centers between January, 2011 and July, 2021. Clinicopathologic characteristics, procedure-related complications, surgical outcomes, and risk factors for short-term mortality were analyzed.Results: During a median follow-up period of 26 months (range: 0.5–60 months), 40 patients (47.1%) underwent ileostomy preferentially in clinical situations with tumor in ascending colon/hepatic flexure, complete obstruction, and more advanced tumor stage compared to SEMS group. No significant differences were found in procedure-related complications. Multivariate Cox regression analysis revealed that ileostomy as a bridge treatment was associated with increased likelihood of 1-year mortality (hazard ratio, 17.805; 95% confidence interval, 1.924–164.788; P = 0.011).Conclusions: In this study, ileostomy as a bridge to surgery showed a significantly higher mortality rate than stent placement. However, these results should be considered when performing ileostomy in patients with more advanced malignant obstruction of the right colon.
Corrected flow time and respirophasic variation in blood flow peak velocity of radial artery predict fluid responsiveness in gynecological surgical patients with mechanical ventilation
Authors: Shen Jianjun , Dai Shaobing , Tao Xia , Chen Xinzhong , Xu Lili 
Published: May 2022

Abstract
BACKGROUND: Recent evidence suggests that ultrasound measurements of carotid and brachial artery corrected flow time (FTc) and respirophasic variation in blood flow peak velocity (ΔVpeak) are valuable for predicting fluid responsiveness in mechanical ventilated patients. We performed the study to reveal the performance of ultrasonic measurements of radial artery FTc, and ΔVpeak for predicting fluid responsiveness in mechanical ventilated patients undergoing gynecological surgery.METHODS: A total of eighty mechanical ventilated patients were enrolled. Radial artery FTc and ΔVpeak, and non-invasive PPV were measured before and after fluid challenge. Fluid responsiveness was defined as an increase in stroke volume index (SVI) of 15% or more after the fluid challenge. RESULTS: Forty-four (55%) patients were fluid responders. Multivariate logistic regression analysis showed that radial artery FTc and ΔVpeak were the independent predictors of fluid responsiveness, with odds ratios of 1.152 [95% confidence interval (CI) 1.045 to 1.270] and 0.581 (95% CI 0.403 to 0.839). The area under the ROC curve of fluid responsiveness predicted by FTc was 0.802 (95% CI, 0.706-0.898), and ΔVpeak was 0.812 (95% CI, 0.714-0.909). The optimal cut-off values of FTc for fluid responsiveness was 336.6 ms (sensitivity of 75.3%; specificity of 75.9%), ΔVpeak was 14.2% (sensitivity of 88.2%; specificity of 67.9%). The grey zone for FTc was 313.5-336.6 ms, ΔVpeak was 12.2-16.5%.CONCLUSIONS: Ultrasound measurement of radial artery FTc and ΔVpeak are the feasible and reliable methods for predicting fluid responsiveness in mechanically ventilated patients.The trial was registered at the Chinese Clinical Trial Registry (ChiCTR)(www.chictr.org), registration number ChiCTR-ICR-2000040941.This study was approved by the Research Ethics Committee of Women’s Hospital, Zhejiang University School of Medicine (20200197).
Using simulated patients and real patients in undergraduate medical education: A qualitative exploration
Authors: Kodikara Kaumudee G. , Seneviratne Thilanka , Premaratna Ranjan 
Published: May 2022

Abstract
Background
Patient interaction is identified as a key learning experience in undergraduate medical education. A real patient or a simulated/standardized patient (SP) can be used for this purpose. Although both real patients and SPs have their inherent advantages and disadvantages in undergraduate medical education, the value of using SPs as opposed to real patients is recognized as an important area warranting research. The objective of this study was to explore the students’ perception on the use of real patients and simulated patients in their education.
Methods
Three focus-group interviews were conducted using medical undergraduates in the 3rd, 4th and final year batches of Faculty of Medicine, University of Kelaniya, Sri Lanka from July to August 2020. The interviews were recorded, transcribed and were analyzed for recurring themes.
Results
All the participants considered real patient encounters to be more authentic than SP encounters. The students identified many strengths of SP interactions. SP encounters enabled them to prepare for real patient encounters. In particular, the participants appreciated the opportunity to practice communication skills in the simulated setting with SPs. Further, the students valued the feedback provided by SPs. The students identified real patient encounters in the clinical setting to be better than SP encounters in learning physical examination skills and procedural skills. Interestingly, real patient encounters were identified as more instructive by the majority and some students identified “the nervousness and anxiety” that is associated with real patient encounters to be valuable and helps to improve self-confidence.
Conclusions
Students identified specific strengths and weaknesses in both real patient encounters and SP encounters. Each encounter was appreciated for learning and improving clinical skills and thus suggest incorporation of both in undergraduate medical education.
Effects of natural antioxidants on the lipid oxidation, physicochemical and sensory characteristics, and shelf life of sliced salami Characteristics/shelf life of salami added with natural antioxidants
Authors: Demarco Fabrício , Rômio Ana Paula , Alfaro Alexandre , Tonial Ivane Benedetti 
Published: May 2022

Abstract
This study aimed to use natural antioxidants (rosemary and curry leaf extracts - AT1 and a mixture of tocopherols - AT2) in sliced salami to prevent lipid oxidation, preserve physicochemical and sensory characteristics, and increase the shelf life. Five formulations were developed in addition to a control formulation and physical-chemical, microbiological and sensory evaluations were performed. The physicochemical and sensory characteristics did not change and the sliced salami was microbiologically suitable for consumption at the end of the 120 days. The natural antioxidants at the concentrations tested slowed down the oxidation reactions, preserved the color and provided a 30-day extension in the shelf life of sliced salami.
Study on the anti-tumor mechanism of Poria triterpenoids on mouse ascites tumor based on Lable-free proteomics
Authors: Dai Junyi , Fang Xiao , Zhu Yao , Yin Can , Liu Yanwen , You Pengtao , Zan Junfeng 
Published: May 2022

Abstract
In order to understand the mechanism of tumor suppression of Poria triterpene on H22 ascites tumor, this paper used HPLC-LTQ-Orbitrap method to detect and identify the chemical composition of Poria triterpene site, based on the use of Lable-free proteomics, so as to explore the potential mechanism of action of Poria triterpene on tumor suppression of mouse ascites tumor. A total of 19 triterpenoids were identified by chemical composition profiling of Poria triterpenes, and 188 differentially expressed proteins were found in Poria triterpene group compared with the model group, of which 86 differentially expressed proteins were upregulated and 102 differentially expressed proteins were downregulated by GO database analysis; the differentially expressed proteins were mainly involved in the regulation of leukocyte GO database analysis showed that differentially expressed proteins were mainly involved in the regulationof interleukin-1 production, arachidonic acid secretion, autophagy and other biological processes; KEGG database analysis showed that differentially expressed proteins were involved in signaling pathways that were closely related to tumors, mainly MAPK, Apoptotic acid, and other proteins. Mainly MAPK, Apoptosis, mTOR, Wnt and p53 pathways; RT-qPCR was used to validate the genes encoding seven representative differential proteins at the mRNA level, and then Western blot was used to validate the differential proteins, and the results were consistent with the proteomic results. The mechanism of tumor suppressive effect of Poria triterpenes on mouse ascites tumor was found to be mainly involved in apoptosis, inflammatory response and immune process.
Low lipoprotein(a) concentration is associated with higher atrial fibrillation risk: A large retrospective cohort study
Authors: Jiang Long , Yang Xinlei , Tao Junjie , Qiu Qinkai , Gao Feng , Chen Wenchong , Hu Lijuan , Xu Yuan , Yi Yingping 
Published: May 2022

Abstract
BACKGROUND AND AIMS: The role of serum lipoprotein(a) [Lp(a)] levels in atrial fibrillation (AF) is still uncertain, especially in the Chinese population. Here we aimed to elucidate the potential relationship between Lp(a) quantiles and AF risk.METHODS: From 2017 to 2021, 4,511 patients with AF and 9,022 patients without AF were 1:2 matched by the propensity score matching method. Interactions between AF risk, Lp(a) quantiles, and other clinical indices were analyzed by logistics regression and stratified analysis.RESULTS: 46.9% of the study group were women, and the baseline mean age exhibited 65 years. The AF group exhibited lower median Lp(a) than the non-AF group (15.95 vs. 16.90 mg/dL; P<0.001). The AF risk decreased from 34.2% (Q1) to 30.9% (Q4) (P<0.001). Lp(a) quantiles 1-3 increased the AF risk 1.162 fold (1.049-1.286), 1.198 fold (1.083-1.327), and 1.111 fold (1.003-1.231) in the unadjusted logistics model, respectively. Lp(a) levels in female patients exhibited significantly negatively correlated with AF (OR of Q1: 1.394[1.194-1.626], P=0.001). Age and hypertension did not affect the adverse correlation.CONCLUSION: For female patients whose serum Lp(a) concentration was less than 16.54 mg/dL, there was a higher risk of suffering from AF. Thus, we recommend a pre-emptive screening for AF in women with low Lp(a) plasma levels.
Sex as a biological determinant in the anthropometric, biochemical, and dietary changes during Ramadan fasting in healthy people: A systematic review of observational studies
Authors: Faris MoezAlIslam , Abdelrahim Dana , Rachida Roky , Krami Al Mahdi , Nadia Aadil 
Published: May 2022

Abstract
Methods
A systematic search was conducted on Scopus and PubMed for experimental and observational studies tackling Ramadan fasting, dietary, anthropometric, and biochemical outcomes in both women and men. Data were extracted using a standardized data-collection form by two independent reviewers.
Results
From about 3870 studies, sex-based differences were reported in 29 studies, which included 3167 healthy people, of which 1558 (40.3%) were women. Most of the differences between men and women were reported both in the baseline period before Ramadan and during Ramadan. Sex differences were examined in a total of 69 outcomes of observing RDIF and included different nutrition and health-related aspects such as dietary and nutrition-related factors (17 outcomes), anthropometrics (13 outcomes), and biochemical (39 outcomes), with the latter including metabolic, hormonal, regulatory, inflammatory and diet-related biochemical markers.
Conclusion
A growing attention has been directed toward the sex differences concerning dietary and lifestyle modifications such as RDIF. Clear differences were observed in the tested dietary, anthropometric, and biochemical outcomes induced by RDIF. More attention has to be directed toward the inclusion of both sexes in studying the impact of observing RDIF and differentiating the outcomes based on the sex differences.
Faba bean (Vicia faba L) seed value chain: implications for a sustainable seed supply in Eastern Amhara Region, Ethiopia
Authors: Kassa Yehuala , Giziew Almaz , Teferra Beneberu 
Published: May 2022

Abstract
This study presents the production performance of faba beans, yield gap, and adoption of improved varieties. Also, it identifies and maps the actors involved in the seed value chain. The paper was based on primary data collected from randomly selected 168 farmers. The result revealed that the adoption rate of improved faba bean seed in the study area at the household level was 23%. It was low mainly due to a lack of access to improved seeds (59.5%) and a lack of awareness about the availability of improved varieties (23%). The average yield of adopters was 13% higher than non-adopters thus reducing the yield gap relative to research fields to 56.6% from 61.6% for non-adopters. They also received an 11% price premium for better seed quality, uniform appearance, and bigger beans of their produce. Farmers’ most important source of planting material was their own saved seed. The formal seed sector supplies only about 2.2% of the seed requirement of faba beans. Hence, own saved seed, community-based seed production, scaling up activities, seed producer and marketing cooperatives and farmer to farmer seed exchange were found to be the main source of a faba bean seed. The study recommends the promotion of improved faba bean varieties, improving access to extension service, strengthening and improving the informal seed system, and linking and integrating all the actors in the chain. The institutional linkage and intensive communication between all stakeholders is also pertinent for technology scaling up and farmers’ easy access to improved seed.
Modeling the indentation size effects of polymers, based on couple stress elasticity and shear transformation plasticity
Authors: Peng Chao , Zeng Fanlin 
Published: May 2022

Abstract
This work attempts to find out the models which can describe the size effects in modulus and hardness of polymers measured by indentation tests. Firstly, the elastic size effects are described by a model, through introducing a model of elastic unloading load with consideration of couple stress elasticity into the Oliver-Pharr indentation approach. The accordingly proposed modulus model and hardness model agree excellently with a large amount of experimental data obtained from literatures. The models show that the elastic size effects of polymers and their experimental observations are mainly determined by the molecular structures. The fitting results verify that the size effects in indentation hardness of polymers with complex molecular structures are significantly elastic. Secondly, it is postulated that the plastic size effects in indentation hardness of polymers are only derived from their glassy components. A shear transformation plasticity theory proposed for glassy polymers is employed to characterize the plastic size effects. A hardness model is accordingly proposed and agrees well with related experimental data.
On the Nanophthalmus fauna of Georgia (Coleoptera: Staphylinidae: Scydmaeninae)
Authors: Assing Volker 
Published: May 2022

Only two named species of Nanophthalmus Motschulsky, 1851 were previously known from Georgia. A study of mostly recently collected material from Georgia yielded nine additional species, one of them previously described and reported from Georgian territory for the first time, two unnamed (male unknown), and six newly described and illustrated: Nanophtalmus egrisicus spec. nov. (Zemo Svaneti); N. svaneticus spec. nov. (Zemo Svaneti); N. truncatus spec. nov. (Racha); N. brachati spec. nov. (Kvemo Svaneti); N. convexus spec. nov. (Adjara); N. simplex spec. nov. (Adjara). The identity and taxonomic status of N. armeniacus (Reitter, 1884), a previously probably misinterpreted species, are discussed. The Georgian Nanophthalmus species are anophthalmous and locally endemic, three in the Lesser Caucasus and five in the Greater Caucasus west of South Ossetia. Their distributions are mapped. The genus now includes a total of 19 described species.
Taxonomic acts
Nanophthalmus brachati spec. nov. – urn:lsid:zoobank.org:act:839F9CB9-48AD-4468-8C2E-2B938E215426 Nanophthalmus convexus spec. nov. – urn:lsid:zoobank.org:act:8ADC681F-B423-4D3D-AAEE-7FE22C0024E9 Nanophthalmus egrisicus spec. nov. – urn:lsid:zoobank.org:act:65510254-39B3-4515-A167-3EE5AA314978 Nanophthalmus simplex spec. nov. – urn:lsid:zoobank.org:act:A80BEF2E-A12F-45FD-95EA-0A49BA3FB407 Nanophthalmus svaneticus spec. nov. – urn:lsid:zoobank.org:act:2D324FFE-B0B5-47B6-86F3-181A88B591D7 Nanophthalmus truncatus spec. nov. – urn:lsid:zoobank.org:act:92C16788-BA1A-4A0F-8871-83658AA468D0
Review of the genus Pelecocera Meigen, 1822 (Diptera, Syrphidae) in the Palaearctic with the description of a new species from Cyprus
Authors: Van Eck Andre , Mengual Ximo 
Published: May 2022

The study of the hoverfly fauna of Cyprus resulted in the discovery of one new species to science, Pelecocera hederae van Eck spec. nov. In the present study, the new species is described in full and all other Palaearctic Pelecocera species are commented. As a result of this study, a revised identification key to the Palaearctic species of Pelecocera is presented. In addition, we performed a DNA barcoding analysis for the Palaearctic species of Pelecocera, including new DNA data and all the Pelecocera sequences publicly available. DNA barcoding supports the new species Pelecocera hederae van Eck spec. nov., as well as most of the Palaearctic species of this genus, with the exception of two pairs of taxa: Pelecocera (Chamaesyrphus) japonica (Shiraki, 1956) and Pelecocera (Chamaesyrphus) lusitanica (Mik, 1898), and Pelecocera (Chamaesyrphus) pruinosomaculata Strobl, 1906 and Pelecocera (Chamaesyrphus) scaevoides (Fallén, 1817).
Taxonomic acts
Pelecocera hederae spec. nov. – urn:lsid:zoobank.org:act:6674C895-CB63-4379-BA8B-227F779481CF
Interlaboratory comparison of the intensity of drinking water odor and taste by two-way ordinal analysis of variation without replication
Authors: Gadrich Tamar , Kuselman Ilya , Pennecchi Francesca R. , Hibbert D. Brynn , Semenova Anastasia A. , Cheow Pui Sze , Naidenko Vladimir N. 
Published: May 2022

Abstract
A case study of ordinal data from human organoleptic examination (sensory analysis) of drinking water obtained in an interlaboratory comparison of 49 ecological laboratories is described. The recently developed two-way ordinal analysis of variation (ORDANOVA) is applied for the first time for the treatment of responses on the intensity of chlorine and sulfurous odor of water at 20 and 60 °C, which is classified into the six categories from ‘imperceptible’ to ‘very strong’. The one-way ORDANOVA is used for the analysis of the ‘salty taste’ intensity of the water. A decomposition of the total variation of the ordinal data and simulation of the multinomial distribution of the data-relative frequencies in different categories allowed the determination of the statistical significance of the difference between laboratories in classifying chlorine or sulfurous odor intensity by categories, while the effect of temperature was not significant. No statistical difference was found between laboratories on salty taste intensity. The capabilities of experts to identify different categories of the intensity of the odor and taste are also evaluated. A comparison of the results obtained with ORDANOVA and ANOVA showed that ORDANOVA is a more useful and reliable tool for understanding categorical data such as the intensity of drinking water odor and taste.