bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid range expansion of an invasive flatworm, Kontikia andersoni, on subantarctic Macquarie Island
Authors: Houghton Melissa Jane , Terauds Aleks , Shaw Justine D 
Published: February 2022

Abstract
Spanning the Southern Ocean high latitudes, subantarctic islands are protected areas with high conservation values. Despite the remoteness of these islands, invasive species threaten their native species and ecosystem function. The most ubiquitous and speciose group of invasive species are invertebrates. Due to their cryptic habits and ambiguous establishment history, the impacts of invasive invertebrates on native species and ecosystems in the region remains largely unknown. Understanding how invasive invertebrate species are transported, disperse, establish and colonise new habitats is key to understanding their existing and future impacts. This knowledge is also fundamental to improving biosecurity practise and informing future management of Southern Ocean islands. We undertook invertebrate surveys on Macquarie Island to determine the current status of four non-native macro-invertebrates - Kontikia andersoni and Arthurdendyus vegrandis (Platyhelminthes: Geoplanidae), Styloniscus otakensis (Isopoda: Styloniscidae) and Puhuruhuru patersoni (Amphipoda: Talitridae). We found A. vergrandis, S. otakensis and P. patersoni had not markedly expanded their range. In contrast, K. andersoni has more than doubled its previously mapped area and expanded at a rate of ~500m−yr since 2004. We discuss the possible underlying mechanisms for the dramatic range expansion of K. andersoni and consider the implications for the future management of Macquarie Island.
Multidisciplinary Lifestyle Interventions In The Management of Resistant Hypertension
Authors: Espinel Eugenia , Azancot Maria Antonia , Gomez Alba , Beneria Anna , Caraben Anna , Andurell Laura , Delgado Pilar , Castañé Helena , Joven Jorge , Seron Daniel 
Published: February 2022

Abstract
Resistant hypertension renders patients refractory to pharmacological treatment and is closely associated with excess weight and high cardiovascular risk. Resistant hypertension and obesity-associated hypertension share highly interrelated and interacting pathogenic mechanisms exacerbated by adiposity that propagate end organ damage including chronic kidney disease and cardiovascular disease. Perhaps it is time to contemplate in the overall management of hypertension, invasive procedures focused on weight loss. Lifestyle interventions improved results from pharmacotherapy alone in a cohort of patients with resistant hypertension. After 6 months of intensive multidisciplinary care, we found significant reductions in blood pressure, body mass index, and antihypertensive medication burden with improvement in cardiovascular disease biomarkers. Increased physical activity and weight loss appeared to be significant factors. Weight-loss drugs are generally ineffective but the impact of laparoscopic sleeve gastrectomy in another cohort of patients with obesity grade 3 and hypertension, was relevant with hypertension remission in more than 50% of cases and significant reductions in blood pressure and medication burden in those who remained hypertensive. Our results suggest the need to define in future studies and selected patients the potential role of combining medical multidisciplinary care with surgical interventions in the management of patients with resistant hypertension and high cardiovascular risk.
Self-medication practices and their characteristics among Iran university students
Authors: Rahimisadegh Rohaneh , Sharifi Nader , Jahromi Vahid Kohpeima , Zahedi Razieh , Rostayee Zahra , Asadi Razieh 
Published: February 2022

Abstract
Background: Self-medication in students as educated people is one of the most important health issues. It is known that inappropriate self-medication is harmful for individuals due to some potential risks and also harmful to the government because disrupts the drug market and increases the per capita financial drug consumption. Thus, the aim of this study is to investigate the habits related to rational use of drug (RUD) and the prevalence of self-medication practices among students. Methods: A cross-sectional study was conducted in 2021 at Jahrom universities/Iran using an electronic “Self-medication practices and medication habits” questionnaire. The 848 students from four healthcare and non-healthcare faculties participated in the study. Results: The prevalence of self-medication among students was 44.8%. The most common medicines on self-medication were cold remedies and sedatives in about 33%. About 47% of students had used antibiotics without a doctor's prescription. The internet and social networks were the source of information about the RUD in about 40% of students. There was no difference in RUD between medical and non-medical students (OR = 0.865, 95% CI: 659-1.134). RUD in students with underlying disease was higher than students without underlying disease (OR = 2.8, 95% CI: 1.39-5.60). Conclusions: Self-medication was high prevalence in students. The best strategy in this high level of self-medication is to raise students' awareness and knowledge by colleges about potential risk of self-medication practices.
The First Horse Gut Microbiome Gene Catalog Reveals That Rare Microbiome Ensures Better Cardiovascular Fitness During Endurance Racing
Authors: Mach Núria , Midoux Cédric , Leclercq Sébastien , Pennarun Samuel , Moyec Laurence Le , Rué Olivier , Robert Céline , Sallé Guillaume , Barrey Eric 
Published: February 2022

Abstract
Emerging evidence indicates that the gut microbiome contributes to endurance exercise performance, but the extent of their functional and metabolic potential remains unknown. Using elite endurance horses as a model system for exercise responsiveness, we built the first equine gut microbial gene catalog comprising more than 25 million non-redundant genes representing 4,696 genera spanning 95 phyla. The unprecedented resolution unrevealed functional pathways relevant for both the structure of the microbiome and the host health and recovered 369 novel metagenome-assembled bacterial genomes, providing useful reference for future studies. Integration of microbial and host omic datasets suggested that microbiomes harboring rare species were functionally dissimilar from those enriched in Lachnospiraceae taxa. Moreover, they offered expanded metabolic pathways to fine-tune the cardiovascular capacity through mitochondria-mediated mechanisms. The results identify an associative link between horse endurance capability and its microbiome gene function, laying the basis for nutritional interventions that could benefit endurance athletes.
High-sensitivity temperature sensor based on microstructured fiber outside coated with gold and PDMS films
Authors: feng yuhui , LI HONGYU , MENG XIAOJIAN , LI MENGQIANG , LI SHUGUANG 
Published: February 2022

Abstract
A high-sensitivity temperature sensor based on microstructured fiber (MSF) outside coated with gold and Polydimethylsiloxane (PDMS) films has been presented in this paper. The gold film is coated outside the fiber cladding, wich is used to excite the surface plasmon resonance (SPR), and PDMS is a kind of substance with high thermo-optical coefficient and easy to be cured, the temperature response has been effectively improved by depositing PDMS film outside the gold film. The influences of the parameters on the sensing characteristics are investigated by using the finite element method (FEM). Simulation results show that the average temperature sensitivity is up to 9.287nm/℃ in the range of -20℃-40℃. Moreover, compared with other designs, the fully coated structure on the outside of MSF enables temperature-sensitive medium to be in direct contact with the environment, which reduces the difficulty of internal coating and filling in the air-holes of MSF. The optimized process of structure in this study provides an effective method, and the temperature sensor based on MSF has good application prospects in the fields such as medical treatment, biochemical detection, and intelligent monitoring.
Sexuality and Psychological Well-being in Different Polycystic Ovary Syndrome Phenotypes Compared with Healthy Controls: A Cross-sectional Study
Authors: Bahadori Fatemeh , Sadatmahalleh Shahideh Jahanian , Montazeri Ali , Nasiri Malihe 
Published: February 2022

Abstract
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. The present study aimed to compare the women with different PCOS phenotypes with the healty group in terms of sexual function, depression, anxiety and quality of life scale.Materials and Methods: The present cross-sectional study was carried out on 192 infertile women with PCOS (classified on the basis of Rotterdam criteria into four categories) and 50 healthy controls. All participants were asked to fill out the valid and reliable questionnaires of FSFI (Female Sexual Function Index), HADS (Hospital Depression and Anxiety Scale) and SF-12.Results: In the HADS questionnaire, phenotype B achieved the highest mean score in anxiety and depression domains, whereas, phenotype B had the lowest mean score in the FSFI and SF-12 quassionnaires. Furthermore, there was a significant difference between the women with PCOS phenotypes and the control grroup in arousal, lubrication, pain, and mean total score of FSFI (P<0.05). In regression logistic analysis, age, infertility and depression were predictors of sexual dysfunction (P<0.05).Conclusion: The results indicated significant differences in terms of sexual dysfunction, depression, anxiety and quality of life in the women suffering from different phenotypes of PCOS compared with the healthy group. These results provide evidence that care and recommendations for improving women’s QoL and sexual function should be considered according to the relevant PCOS phenotypes.
Hadrosauroid eggs and embryos from the Upper Cretaceous (Maastrichtian) of Jiangxi Province, China
Authors: Xing Lida , Niu Kecheng , Yang Tzu-Ruei , Wang Donghao , Miyashita Tetsuto , Mallon Jordan C. 
Published: February 2022

Abstract
Background: Dinosaur eggs containing embryos are rare, limiting our understanding of dinosaur development. Recently, a clutch of subspherical dinosaur eggs was discovered while blasting for a construction project in the Upper Cretaceous red beds (Hekou Formation) of the Ganzhou basin, Jiangxi Province, China. At least two of the eggs contain identifiable hadrosauroid embryos, described here for the first time.Results: The eggs, attributable to Spheroolithidae indet., are thick-walled but small (~660 mL) compared to those of Lambeosaurinae. Based on the distinctive shape of the squamosal, the embryos compare favourably with Nanningosaurus dashiensis, otherwise known from incomplete skeletal material from Upper Cretaceous red beds elsewhere in southern China.Conclusion: The small size of the eggs and embryos, similar to those of Hadrosaurinae, indicates that the larger eggs and hatchlings of typical Lambeosaurinae are evolutionarily derived.
Wearable Technology for Health Monitoring During Pregnancy: an Observational Cross-sectional Survey Study
Authors: Wakefield Colin , Yao Lena , Self Steve , Frasch Martin G. 
Published: February 2022

Abstract
Purpose: To evaluate how pregnant women perceive the use of remote fetal ECG monitoring technologies. Telemedicine has advanced to the forefront of healthcare delivery, including maternal-fetal medicine. Smart wearable electrocardiogram (ECG) devices can enable pregnant women to monitor their health and that of their fetuses. Such technology would be a logical extension of the telemedicine ecosystem.Methods: We conducted an observational cross-sectional study via online surveying in the United States. Study participants were recruited using the SurveyMonkey Audience Polling system and responded virtually. In all, the sample consisted of 507 women, aged 18-45 from 45 states, who are expecting to become pregnant in the next five years. Women were asked to identify their willingness to use a wearable ECG device the size of a patch-sized large band-aid on their abdomen. Ten binary or multiple-choice questions were used to gauge population interest and related demographics towards the usage of a wearable ECG device. Results: Of the 507 participants, 461 (91%) women expressed an acceptance of wearable ECG technology throughout the pregnancy as a mechanism for increased frequency of monitoring of maternal and fetal health outside the hospital. 395 (78%) women demonstrated a willingness to wear devices day and night or at least during sleep and 213 (42%) of the women would spend up to $200 on such a device. Conclusion: Even though conducted prior to the COVID-19 pandemic, this study clearly indicates a high degree of readiness of prospective pregnant women for telemedicine with continuous health monitoring of the mother-fetus dyad.
Patient-Controlled Sedation in Port Implantation (PACSPI 1) – a Feasibility Trial
Authors: Seifert Stefanie , Taxbro Knut , Hammarskjöld Fredrik 
Published: February 2022

Abstract
Purpose: Central venous access is essential for the administration of chemotherapy and frequent blood sampling in patients with cancer. The subcutaneous venous port (SVP) is commonly used for this purpose. SVP implantation is a minor surgical procedure; however, it can provoke pain and anxiety in these vulnerable patients. The aim of this study was to determine the feasibility and safety of patient-controlled sedation (PCS) with propofol and alfentanil as an adjunct to local anesthesia during SVP implantation.Methods: We prospectively studied 40 patients scheduled for SVP implantation between April 14, 2021, and October 15, 2021, at a 500-bed secondary level hospital in Sweden. Anesthesiologists performed SVP implantation with PCS using propofol and alfentanil. We determined pain perception (primary outcome), patient satisfaction, sedation score, and key safety measures.Results: Of the 40 patients with cancer, 80% reported a pain score ≤3 on an 11-point numeric rating scale (NRS) during SVP implantation. Overall satisfaction with pain management and operating conditions was graded as 10 of 10 on the NRS. Four patients (10%) had bradypnea (<8 breaths/min) without oxygen desaturation to ≤90%. Rescue sedation was administered to one patient (2.5%). Conclusion: PCS with propofol and alfentanil during SVP implantation is feasible, safe, and well accepted. Its efficacy must be evaluated in a randomized controlled trial to provide clinicians with evidence-based guidance for choosing the optimal perioperative strategy for SVP implantation.Trial registration number at clinicaltrials.gov: NCT04631393 before study commencement.
Effect of Taurine Supplement on Aerobic and Anaerobic Outcomes: Meta-Analysis of Randomized Controlled Trials
Authors: Buzdağlı Yusuf , Eyipınar Cemre Didem , Tekin Aslıhan , Şıktar Erdinç , Zydecka Karolina Skonieczna 
Published: February 2022

Abstract
Background: Taurine is a well-known free amino acid that has gained prominence in recent years despite its little or no role in protein formation. Few studies on the ergogenic effect of taurine exist with inconsistent results. The question on whether performance markers show the benefit from the taurine remains open. This study aimed to reach a consensus about whether taurine supplementation is effective on aerobic (time to exhaustion, VO2max, and rating of perceived exertion) and anaerobic (jumping, blood lactate level) performance outputs. Methods: Google Scholar, Pubmed databases, clinical trial websites, and grey literature were reviewed until November 2021. Mean differences (MDs) were pooled using random or fixed-effects models according to the heterogeneity degree of related outcomes. Although 17 studies were detected for the meta-analysis between 2001-2021, 15 studies were grouped. Only randomized controlled trials (single or double-blind) were considered. Results: Taurine supplementation had a significant effect on vertical (MD =3.60; 95% CI 2.32 to 4.89, p <0.00001) and countermovement (MD = 8.50; 95% CI 4.78 to 12.22, p <0.00001) jump performance when compared to a placebo group. Taurine supplementation had no significant effect on VO2max level and rate of perceived exertion (respectively, MD = −0.54 ml/kg/min; 95% CI −6.84 to 5.75, p=0.87; MD = −0.24; 95% CI −0.74 to 0.27, p=0.35) when compared to a placebo group. Conclusion: Taurine improves potentially jumping performance and time to exhaustion.
TIMP1, CLCA1 and KLF4 are the Prognostic Biomarkers for the Development of Colon Cancer
Authors: Zhang Guoliang , Li Bing , Xu Xuejie , Wu Weidan , Zheng Linlin 
Published: February 2022

Abstract
Objective: Colon cancer (CC) is one of the most common malignant diseases that poses a serious threat to human health. The aim of this study was to identify critical biomarkers or features that may be used as potential targets for early diagnosis and treatment monitoring of CC. Methods: Two microarray datasets of colorectal cancer were downloaded from the Gene Expression Omnibus (GEO) database. The transcriptome and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. The method of robust rank aggregation was adopted to integrate differentially expressed genes (DEGs). The protein-protein interaction (PPI) network of the DEGs was constructed using the STRING platform, and hub genes were identified using the Cytoscape plugin cytoHubba. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analysis were performed using DAVID online tool. Kaplan Meier survival analysis were used to evaluate the prognostic value of the hub genes. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic value of the genes. Pearson’s correlation analysis was utilized to detect the relationship between the prognostic genes and infiltrated immune cells. The human protein atlas (HPA) database was used to verify the protein expression of the prognostic genes. Results: A total of 501 robust DEGs were obtained by integrating datasets from GEO and TCGA. Fifty genes were screened as hub genes using Cytoscape. Functional analysis revealed that the hub genes were mainly involved in the chemical carcinogenesis, ECM-receptor interaction, focal adhesion, tight junction, PI3K-Akt signaling pathway and cytokine-cytokine receptor interaction. Six of the hub genes were associated with prognosis in CC, including TIMP1, VEGFA, KLF4, GCG, CXCL8, and CLCA1. All the 6 genes have high diagnostic value for CC identification, and were involved in some immune cells infiltration. Among the above 6 genes, the expression of TIMP1, KLF4, and CLCA1 in HPA database were mostly corresponding with gene expression profile. Conclusions: TIMP1, CLCA1 and KLF4 were the key genes that associated with the development of CC, and may act as effective biomarkers that indicate the prognosis of CC.
Combination Technique Using Patchwork and Partial Softening to Determine the Collision Toughness and Intrusion Prevention in Side Crash Simulation
Authors: Lee Min-Sik , Jin Chul-Kyu , Lim Ok-Dong , Suh Jun-Ho 
Published: February 2022

Abstract
Various techniques have been applied to center pillar to enhance collision characteristics during side crash. Among these techniques, the patchwork (PW) was welded to center pillar to strengthen the stiffness and partial softening (PS) was applied to provide ductility. Side crash test was conducted by Insurance Institute for Highway Safety (IIHS) to evaluate collision resistance. But it is hard to evaluate collision toughness and energy distribution flow for each automobile component. In this study, the side crash simulation was performed along with IIHS instruction. The effect of Hot Press Forming (HPF) center pillar with the combination techniques of PW and PS on collision toughness and energy distribution flow was investigated. As a results, the role of PW and PS techniques were verified during side crash. The strain energy and intrusion displacement by PW were improved 10, 7.5% respectively and the plastic deformation energy and intrusion displacement by PS were improved 10%. When PW and PS were applied to the HPF center pillar simultaneously, the synergy effect of PW and PS occurred.
Impact of COVID-19 Lockdown on Maternal Psychological Status, The Couple’s Relationship and Mother-Child Interaction: A Prospective Study.
Authors: Savelon Sylvie Viaux , Maurice Paul , Rousseau Alexandra , Laufer Chloé , Renout Manon , Berlingo Laura , Cohen David , Jouannic Jean-Marie 
Published: February 2022

Abstract
Background: To compare the rate of postpartum depression (PPD) during the first COVID-19 lockdown with the rate observed prior to the pandemic, and to examine factors associated with PPD.Methods: This was a prospective study. Women who gave birth during the first COVID-19 lockdown (spring 2020) were offered call-interviews at 10 days and 6-8 weeks postpartum to assess PPD using the Edinburgh Postnatal Depression Scale (EPDS). Post-traumatic symptoms (Perinatal Post-traumatic Stress Disorder Questionnaire, PPQ), couple adjustment, and interaction and mother-to-infant bonding were also evaluated. The observed PPD rate was compared to the one reported before the pandemic. Factors associated with an increased risk of PPD were studied. The main outcome measures were comparison of the observed PPD rate (EPDS score>12) to pre-pandemic rate. Results: Of the 164 women included, 27 (16.5% [95%CI: 11.14 – 23.04]) presented an EPDS score>12 either at 10 days or 6-8 weeks postpartum. This rate was similar to the one of 15% reported prior to the pandemic (p=0.6). Combined EPDS>12 or PPQ>6 scores were observed in 20.7% of the mothers [95%CI: 14.8 – 0.28]. Maternal hypertension/preeclampsia (p=0.007), emergency cesarean section (p=0.03), and neonatal complications (p=0.008) were significantly associated with an EPDS>12 both in univariate and multivariate analysis (OR=10 [95%CI: 1.5 – 68.7], OR=4.09[95%CI: 1.2 – 14], OR=4.02[95%CI: 1.4 – 11.6], respectively).Conclusions: The rate of major PPD in our population did not increase during the first lockdown period. However, 20.7% of the women presented with post-traumatic/depressive symptoms.Trial Registration: NCT04366817
Identifying Molecular Aetiology of Syndromic and Non syndromic Renal Disorders using Exome Analysis
Authors: Priya Aruna , Kumar Santosh , Iyer Gayatri R , Hasan Qurratulain 
Published: February 2022

Abstract
Aim: Renal disorders (RDs) are heterogeneous in nature with different ages of onset ranging from in-utero to adults that arise as independent disease and also as syndromes. RDs are of both heritable and acquired type. The aim of this study was to utilize Next Generation Sequencing to identify the molecular basis of syndromic and non syndromic RDs for management and preventative counselling.Methods: In the present study cases of RDs which were identified as a solitary health issue and those which had renal disease as part of syndromic features were offered exome analysis by Next Generation Sequencing (NGS) followed by a specific gene panel evaluation after informed consent. Results: In our study twenty cases were evaluated by NGS based panel tests, a genetic variant was identified in 95% (19/20) of the cases which could be correlated with the renal phenotype. Based on the American College of Medical Genetics and Genomics (ACMG) guidelines 89% (17/19) of the cases were reported with a Pathogenic or likely pathogenic variant and 10% (2/19) with a Variant of uncertain significance. As expected 8/9 cases with features of polycystic Kidney disease and all eleven cases with syndromic RD had a variant which correlated with phenotype.Discussion & Conclusion: NGS enables molecular diagnosis of RD without subjecting patients to invasive tests like renal biopsy as early as the fetal stage. The management and prevention of disease in the family through appropriate genetic counseling is an added advantage.