bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the role of local therapy in patients with cN1M0 prostate cancer: A population-based study from the SEER database
Authors: Qi Feng , Xu Wenbo , Li Lu , Li Xiao , Xu Zicheng 
Published: December 2022

ObjectiveTo investigate the prognostic value of local therapy (LT) in cN1M0 prostate cancer (PCa).MethodsPatients diagnosed with cN1M0 PCa were extracted from the surveillance, epidemiology, and end results (SEER) database. Kaplan-Meier (KM) curve was used to compare the survival outcomes between patients treated with and without LT. Further, among patients receiving LT, KM analysis was also applied to investigate the survival differences in patients with radical prostatectomy (RP) and radiation therapy (RT). Propensity score matching (PSM) analysis was performed to balance the basic characteristics of patients in each group and make it comparable when exploring the survival impact of different treatment types. Finally, uni- and multivariable Cox proportional-hazards models were utilized to identify independent prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS) in this population.ResultsPatients treated with LT had significantly better OS (P&lt;0.0001) and CSS (P&lt;0.0001) than those without LT, as well as in most subgroups, except for non-White patients, or those with ISUP grade group 1 or T3 stage. Notably, patients receiving RP also had significantly better OS (P=0.00012) and CSS (P=0.0045) than those treated with RT alone, especially in those aged ≥75 years old, prostate-specific antigen (PSA) 10-20 ng/mL, ISUP grade 1-3 or non-white patients. Finally, clinical T stage, ISUP grade group and the administration of LT were identified to be independent prognostic factors for OS and CSS among cN1M0 PCa patients.ConclusionThe cN1M0 PCa patients treated with LT were associated with significantly better survival. Among patients receiving LT, the combination of RP and PLND could lead to a better prognosis compared to RT alone in most subgroups. An individualized treatment strategy is warranted to be developed after weighing the benefits and risks of treatment.
Meta-analysis of the effect of PGM on survival prognosis of tumor patients
Authors: Zheng Zhewen , Bai Jian , Shen Shuangting , Zhu Chunmei , Zhou Yunfeng , Zhang Xue 
Published: December 2022

ObjectiveA systematic evaluation of the impact of phosphoglucose translocase PGM on the survival prognosis of tumor patients was conducted to understand its impact on tumors so as to improve the quality of survival and to find effective therapeutic targets for tumor patients.MethodsThe following were searched in the databases China National Knowledge Infrastructure (CNKI), Wanfang, Wipu, PubMed, EMBASE, ScienceDirect, Web of Science, and Cochrane Library: “PGM1”, “PGM2”, “PGM3”, “PGM4”, and “PGM5” as Chinese keywords and “PGM1”, “PGM2”, “PGM3”, “PGM4”, “PGM5”, “PGM1 cancer”, “PGM2 cancer”, “PGM3 cancer”, “PGM4 cancer”, “PGM5 cancer”, and “phosphoglucomutase”. Relevant studies published from the database establishment to April 2022 were collected. Studies that met the inclusion criteria were extracted and evaluated for quality with reference to the Cochrane 5.1.0 systematic evaluation method, and quality assessment was performed using RevMan 5.3 software.ResultsThe final results of nine articles and 10 studies with a total of 3,806 patients were included, including 272 patients in the PGM1 group, 541 patients in the PGM2 group, 1,775 patients in the PGM3 group, and 1,585 patients in the PGM5 group. Results of the meta-analysis: after determining the results of the nine articles, it was found that the difference was statistically significant with a p-value &lt;0.05 (hazard ratio (HR) = 0.89, 95% CI 0.69–1.09, p = 0.000). To find the sources of heterogeneity, the remaining eight papers were tested after removing the highly sensitive literature, and the results showed I2 = 26.5%, p &lt; 0.001, a statistically significant difference. The HR for high expression of PGM1 and PGM2 and PGM5 was &lt;1, while the HR for high expression of PGM3 was &gt;1.ConclusionAlthough PGM1, PGM2, PGM3, and PGM5 are enzymes of the same family, their effects on tumors are different. High expression of PGM1, PGM2, and PGM5 can effectively prolong the overall survival of patients. In contrast, high expression of PGM3 reduced the overall survival of patients. This study of PGM family enzymes can assist in subsequent tumor diagnosis, treatment, and prognostic assessment.
Diffusion-weighted imaging-based radiomics in epithelial ovarian tumors: Assessment of histologic subtype
Authors: Xu Yi , Luo Hong-Jian , Ren Jialiang , Guo Li-mei , Niu Jinliang , Song Xiaoli 
Published: December 2022

BackgroundEpithelial ovarian tumors (EOTs) are a group of heterogeneous neoplasms. It is importance to preoperatively differentiate the histologic subtypes of EOTs. Our study aims to investigate the potential of radiomics signatures based on diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps for categorizing EOTs.MethodsThis retrospectively enrolled 146 EOTs patients [34 with borderline EOT(BEOT), 30 with type I and 82 with type II epithelial ovarian cancer (EOC)]. A total of 390 radiomics features were extracted from DWI and ADC maps. Subsequently, the LASSO algorithm was used to reduce the feature dimensions. A radiomics signature was established using multivariable logistic regression method with 3-fold cross-validation and repeated 50 times. Patients with bilateral lesions were included in the validation cohort and a heuristic selection method was established to select the tumor with maximum probability for final consideration. A nomogram incorporating the radiomics signature and clinical characteristics was also developed. Receiver operator characteristic, decision curve analysis (DCA), and net reclassification index (NRI) were applied to compare the diagnostic performance and clinical net benefit of predictive model.ResultsFor distinguishing BEOT from EOC, the radiomics signature and nomogram showed more favorable discrimination than the clinical model (0.915 vs. 0.852 and 0.954 vs. 0.852, respectively) in the training cohort. In classifying early-stage type I and type II EOC, the radiomics signature exhibited superior diagnostic performance over the clinical model (AUC 0.905 vs. 0.735). The diagnostic efficacy of the nomogram was the same as that of the radiomics model with NRI value of -0.1591 (P = 0.7268). DCA also showed that the radiomics model and combined model had higher net benefits than the clinical model.ConclusionRadiomics analysis based on DWI, and ADC maps serve as an effective quantitative approach to categorize EOTs.
Measuring respiratory and heart rate using a fiber optic interferometer: A pilot study in a neonate model
Authors: Cubík Jakub , Kepak Stanislav , Wiedermannova Hana , Vrtkova Adela , Burckova Hana , Zarubova Pavla , Fernandez Carlos , Pavlicek Jan , Jargus Jan , Vasinek Vladimir 
Published: December 2022

IntroductionThe study aim was to test the safety and efficacy of a pad with optic fibers developed for monitoring newborn respiratory rate (RR) and heart rate (HR).MethodsThirty New Zealand White rabbits were included, divided by weight into three groups. RR and HR were measured using two methods for each rabbit: ECG electrodes as the reference method and a newly developed pad with an experimental fiber optic system (EFOS) as the experimental method.ResultsAnalysis was performed on data for 29 rabbits (10 female, 34%; 19 male, 66%). EFOS performed better at measuring RR compared with HR. RR values did not differ significantly between the methods for the whole group (p = 0.151) or within each sex (female: p &gt; 0.999; male: p = 0.075). Values for HR, however, did differ between methods for the whole group of animals (p &lt; 0.001) and also within groups by sex (female: p &lt; 0.001; male: p = 0.006).ConclusionThe results of this preclinical study demonstrate the potential of this non-invasive method using a fiber optic pad to measure HR and RR.
Coach leadership in a crisis context: Investigating effective coach behaviors during the COVID-19 pandemic with a process view
Authors: Zhao Chen , Jowett Sophia 
Published: December 2022

IntroductionDrawing from the crisis leadership conceptualization, this study aims to investigate coaches’ opinion patterns on effective leadership behaviors during the COVID-19 pandemic. The study used a process view to explore how coaches as leaders act in pre, during, and post-crisis phases.MethodThirty-two fulltime professional coaches (28 males and 4 females) from individual and team sports who experienced the entire COVID-19 pandemic from January 2020 to July 2021 in the United Kingdom were invited to express their perceptions of effective leadership behaviors. The study used Q methodology to analyze coaches’ perceptions and experiences.ResultThe study revealed that the most effective coach leadership behaviors occurred during-crisis phase, which has the most positive ratings (n = 48) compared to the pre-and post-crisis phases (n = 18). The study’s main findings highlighted different phases of the COVID-19 pandemic demand various effective countermeasures from coaches. These practical and successful experiences were summarized as: division of labor, athlete-centered, team-driven, consulting, safe environment, and online coaching.DiscussionThe findings of this study further highlight (1) the importance of coach leadership in creating a safe environment as it provides a much better platform to prepare for a pre-crisis stage, (2) that coaches should employ more positive than negative behaviors while interacting with team members more frequently especially during the crisis period, reducing athletes’ negative feelings such as anxiety and worry, and (3) that the online training-related activities and interactions during the crisis time can be expanded to noncrisis times, as a crisis event can have positive implications for the future if handled properly.
Characteristics and service use of NSW Quitline callers with and without mental health conditions
Authors: Lodge Simone , Bartlem Kate , Gibson Lauren , Fehily Caitlin , Bradley Tegan , McKeon Emma , Reakes Kate , Rickards Sandra , Hastings Phillipa , Bowman Jenny 
Published: December 2022

IntroductionSmoking rates remain higher for people with a mental health condition compared to the general population and contribute to greater chronic disease burden and premature mortality. Quitline services offer telephone-based smoking cessation support to the public and have been shown to be effective. There is limited research exploring the characteristics of smokers with a mental health condition who use the Quitline or the impacts of using the service on their smoking behaviors.MethodsThis observational study aimed to compare demographic and smoking related characteristics, service use and quit attempts of callers to the New South Wales Quitline (2016–2018) with and without a mental health condition (N = 4,219).ResultsAt baseline, 40% of callers reported a current mental health condition. Desire to quit smoking was similar for both groups, however participants with a mental health condition had higher nicotine dependency and had made more quit attempts prior to engaging with the service. During program enrolment, quit attempts and 24 hours smoke free periods were similar, however participants with a mental health condition engaged in a greater number of calls and over a longer period with Quitline compared to those without.DiscussionThe findings suggest Quitline efficacy for people with a mental health condition in making a quit attempt for at least 24 h. Increasing the use of Quitline services and understanding service use for this critical group of smokers will increase the likelihood that their quit attempts are transformed into sustained periods of smoking abstinence. Future research should explore whether tailoring of Quitline service provision for people with mental health conditions may increase the likelihood of quit success.
The mediating role of general academic emotions in burnout and procrastination among Chinese medical undergraduates during the COVID-19 pandemic: A cross-sectional study
Authors: Qu Ruoyi , Ding Ning , Li Honghe , Song Xinzhi , Cong Zhangzhao , Cai Ruoxin , Zhu Yaxin , Wen Deliang 
Published: December 2022

BackgroundAcademic procrastination has become more prevalent during the COVID-19 pandemic due to teaching/learning changes. This phenomenon induces academic burnout, which is already serious among medical students. However, the academic emotion, which is the factor most vulnerable to changes in the academic environment, is still unknown. Therefore, the current study aimed to investigate the mediating role of general academic emotions in procrastination and burnout among Chinese medical students during the COVID-19 pandemic.MethodsThis cross-sectional study enrolled 995 medical students from China Medical University. We applied the Chinese version of the Maslach Burnout Inventory Student Survey (MBI-SS), the Aitken Procrastination Inventory (API) and the General Academic Emotion Questionnaire for College Students (GAEQ) to evaluate the variables of interest. We examined the mediation effects of GAEs by hierarchical linear regression analysis.ResultsCorrelation analyses showed a significant positive correlation between procrastination and burnout. Procrastination and burnout positively and negatively correlated with negative academic emotions, respectively. Hierarchical linear regression analyses showed that procrastination had positive associations with negative academic emotions, while it had negative associations with positive academic emotions. The contributions (as mediators) of GAEs to burnout and procrastination were 21.16% (NAEs), 29.75% (PAEs), 54.25% (NDEs) and 23.69% (PDEs).ConclusionsThe results indicate that academic emotions had mediating effects on procrastination and burnout. Medical students' worries about the uncertainty of the learning environment may have exacerbated academic burnout. Targeted improvements in the teaching environment to communicate encouragement and reduce anxiety and helplessness among medical undergraduates for implementing medical education while preventing and controlling the infection.
Trends of overweight and obesity prevalence in school-aged children among Henan Province from 2000 to 2019
Authors: Zhang Yuhao , Lou Hao , Huang Ye , Wang Ruijuan , Wen Xiao , Wu Cuiping , Hao Changfu , Li Ran , Gao Genli , Lou Xiaomin , Wang Xian 
Published: December 2022

ObjectivesOverweight and obesity are harmful to human health. However, the latest trends of Chinese childhood overweight and obesity prevalence are not available. The aim of this study was to examine the trends from 2000 to 2019 among students in China.MethodsWe analyzed data of 66,072 students in the Chinese National Survey on Students' Constitution and Health from 2000 to 2019. Overweight and obesity were defined based on the standard formulated by the International Obesity Task Force (IOTF standard), the World Health Organization (WHO standard), and the Working Group on Obesity in China (WGOC standard), respectively. The χ2-test was used to test the trends of overweight and obesity prevalence and logistic regression was conducted to evaluate the prevalence odds ratios of boys vs. girls and urban vs. rural areas.ResultsThe prevalence of obesity/overweight and obesity combined was 6.03/23.58% (IOTF standard), 10.56/25.88% (WGOC standard) and 10.75/29.69% (WHO standard) in 2019. From 2000 to 2019, according to the WGOC standard, the prevalence increased from 2.51 to 10.56% for obesity and increased from 9.81 to 25.88% for overweight and obesity combined (P for trend &lt; 0.001). Obesity/overweight and obesity were greater problems in boys than girls and urban than rural areas, but urban-rural differences decreased over time.ConclusionOverweight and obesity prevalence increased significantly in children and adolescents in China from 2000 to 2019. The prevalence of overweight and obesity in rural areas may contribute to a large percentage of children with overweight and obesity.
Hidden figures: Revisiting doping prevalence estimates previously reported for two major international sport events in the context of further empirical evidence and the extant literature
Authors: Petróczi Andrea , Cruyff Maarten , de Hon Olivier , Sagoe Dominic , Saugy Martial 
Published: December 2022

BackgroundHigh levels of admitted doping use (43.6% and 57.1%) were reported for two international sport events in 2011. Because these are frequently referenced in evaluating aspects of anti-doping, having high level of confidence in these estimates is paramount.ObjectivesIn this study, we present new prevalence estimates from a concurrently administered method, the Single Sample Count (SSC), and critically review the two sets of estimates in the context of other doping prevalence estimates.MethodsThe survey featuring the SSC model was completed by 1,203 athletes at the 2011 World Championships in Athletics (WCA) (65.3% of all participating athletes) and 954 athletes at the 2011 Pan-Arab Games (PAG) (28.2% of all participating athletes). At WCA, athletes completed both UQM and SSC surveys in randomised order. At PAG, athletes were randomly allocated to one of the two surveys. Doping was defined as “having knowingly violated anti-doping regulations by using a prohibited substance or method.”ResultsEstimates with the SSC model for 12-month doping prevalence were 21.2% (95% CI: 9.69–32.7) at WCA and 10.6% (95% CI: 1.76–19.4) at PAG. Estimated herbal, mineral, and/or vitamin supplements use was 8.57% (95% CI: 1.3–16.11) at PAG. Reliability of the estimates were confirmed with re-sampling method (n = 1,000, 80% of the sample). Survey non-compliance (31.90%, 95%CI: 26.28–37.52; p &lt; 0.0001) was detected in the WCA data but occurred to a lesser degree at PAG (9.85%, 95% CI: 4.01–15.69, p = 0.0144 and 11.43%, 95% CI: 5.31–11.55, p = 0.0196, for doping and nutritional supplement use, respectively). A large discrepancy between those previously reported from the UQM and the prevalence rate estimated by the SSC model for the same population is evident.ConclusionCaution in interpreting these estimates as bona fide prevalence rates is warranted. Critical appraisal of the obtained prevalence rates and triangulation with other sources are recommended over “the higher rate must be closer to the truth” heuristics. Non-compliance appears to be the Achilles heel of the indirect estimation models thus it should be routinely tested for and minimised. Further research into cognitive and behaviour aspects, including motivation for honesty, is needed to improve the ecological validity of the estimated prevalence rates.
Integração do sistema de gestão por competências ao sistema de gestão da qualidade na justiça eleitoral / Integration of the competency management system to the quality management system in electoral justice
Authors: Vanderley Luciano Gonzaga 
Published: December 2022

A qualidade é premissa “sinequa non” diante da evolução do nível de exigência dos clientes. É necessário fazer mais com menor custo. O sistema de gestão é o “plus” fundamental para alcançar respostas a mudanças do ambiente. Assim, identifica-se a necessidade de integração de gestão dos processos operacionais. Para isso, entende-se como necessário um modelo de gestão que se proponha explicar as interfaces e os relacionamentos, fazendo esta integração, ou seja, alinhando as ações operacionais aos objetivos estratégicos em uma gestão orientada por um sistema de negócios.Aquestão se coloca: Como efetivar a consecução dos objetivos estratégicos aos negócios e aos stakeholders (eleitores, servidores e fornecedores) relacionados aos processos e à gestão de pessoas? Para responder esta questão, adotou-se o seguinte objetivo geral a ser alcançado: Desenvolver o Sistema de Gestão por Competências ao Sistema de Gestão da Qualidade, baseado na Norma ABNT ISO 9001. Para atender ao objetivo mor, é necessário: aplicar o Sistema de Gestão da Qualidade baseada na Norma ABNT ISO 9001 e empregar o Sistema de Gestão por Competências. O tema propõe a discussão e a integração conjunta da gestão de processos com as competências individuais, focando fortemente nos negócios da organização com seus stakeholders. A problemática compõe a compreensão de cada sistema como pré-requisito, suas interfaces e relacionamentos.Grande parte da bibliografia destaca cada sistema de gestão isoladamente. A discussão da integração contribui para a melhoria de resultados, oferecendo prioridade aos processos operacionais.Este trabalho é uma pesquisa aplicada, qualitativa, exploratória-descritiva, pois buscou-se aplicar um modelo na área contábil-orçamentária-financeira (escopo) na Justiça Eleitoral do Ceará e a partir da experimentação prática construtiva e participativa, envolvendo interação teórico-prática na construção de um modelo de gestão, foram levantados questionamentos e destes foi gerada a proposta de uma sistemática mais completa, numa pesquisa-ação. Em cada um dos componentes do modelo e em parte da aplicação prática faz-se pesquisa descritiva; na discussão das interfaces entre os assuntos e do conhecimento gerado através da interação teórico-prática acerca destas interfaces faz-se pesquisa exploratória. Como se propõe o desenvolvimento de uma sistemática, a partir do referencial teórico, que deverá ser replicado em novos escopos, conclui-se que os procedimentos técnicos ou métodos de pesquisa são a pesquisa bibliográfica e a pesquisa-ação.Neste trabalho, busca-se resolver um problema coletivo de gestão: disponibilizar ao menos alguma ferramenta de gestão de processos e de gestão de pessoas. Para em seguida, integrá-las com a colaboração e participação dos stakeholders na busca de equacionar uma solução ao problema.
Nicotinamide Phosphoribosyl Transferase and Cancer: A Molecular Nutrition Link
Authors: Zhang Li Qin , Heruth Daniel P. , Lee Mark W. , Li Ding-You , Maulik Dev , Ye Shui Qing 
Published: December 2022

Abstract:
Nicotinamide phosphoribosyl transferase (NAMPT, EC 2.4.2.12), a pleiotropic protein, is a key enzyme for cellular NAD synthesis and may function as a growth factor or cytokine. Dysregulation of NAMPT gene expression has been implicated in several human diseases. In recent years, an increasing attention has been drawn to NAMPT’s role in the pathogenesis of cancer and its value as a therapeutic target in cancer therapy. A molecular nutrition link between NAMPT and cancer looms large among the scientific findings. This review article will be centered on this theme. We will summarize the genomic discoveries of NAMPT in cancer and the current understanding of molecular mechanisms underlying NAMPT in the pathogenesis of cancer, especially on a molecular nutrition link. We will also synopsize several small molecule inhibitors of NAMPT and their potential therapeutic utilities in cancer and usher in some terra incognita of future researches on NAMPT in cancer.