bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline
Authors: Mao Jun J. , Ismaila Nofisat , Bao Ting , Barton Debra , Ben-Arye Eran , Garland Eric L. , Greenlee Heather , Leblanc Thomas , Lee Richard T. , Lopez Ana Maria , Loprinzi Charles , Lyman Gary H. , MacLeod Jodi , Master Viraj A. , Ramchandran Kavitha , Wagner Lynne I. , Walker Eleanor M. , Bruner Deborah Watkins , Witt Claudia M. , Bruera Eduardo 
Published: September 2022

PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer. METHODS The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2021. Outcomes of interest included pain intensity, symptom relief, and adverse events. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 227 relevant studies to inform the evidence base for this guideline. RECOMMENDATIONS Among adult patients, acupuncture should be recommended for aromatase inhibitor–related joint pain. Acupuncture or reflexology or acupressure may be recommended for general cancer pain or musculoskeletal pain. Hypnosis may be recommended to patients who experience procedural pain. Massage may be recommended to patients experiencing pain during palliative or hospice care. These recommendations are based on an intermediate level of evidence, benefit outweighing risk, and with moderate strength of recommendation. The quality of evidence for other mind-body interventions or natural products for pain is either low or inconclusive. There is insufficient or inconclusive evidence to make recommendations for pediatric patients. More research is needed to better characterize the role of integrative medicine interventions in the care of patients with cancer. Additional information is available at https://integrativeonc.org/practice-guidelines/guidelines and www.asco.org/survivorship-guidelines .
Trial Registry Use in Neurosurgery Systematic Reviews With Meta-Analyses: A Cross-Sectional Analysis
Authors: Bertolino Blake , Rivera Steven , Perez Brenda , Reddy Arjun K. , Vassar Matt 
Published: September 2022

BACKGROUND:
Quality systematic reviews with meta-analyses (SRMA's) are the standard for recommendations in clinical practice. One problem with the current literature is susceptibility to publication bias, which has been shown to inflate effect estimates of SRMA's.

OBJECTIVE:
To combat publication bias, Cochrane Collaboration requires searching at least 1 clinical trial registry (CTR) for unpublished data. Therefore, we investigated SRMA's published in the top 5 neurosurgery journals and whether they incorporated CTR searches.

METHODS:
All meta-analyses published the top 5 journals in Neurosurgery over the past 5 years were queried using the h-5 index of Google Scholar: Journal of Neurosurgery, Neurosurgery, World Neurosurgery, Journal of Neurosurgery: Spine, and Neurosurgical Focus. Search strings were generated to incorporate SRMA's over the past 5 years in these journals. We selected a random sample of 100 studies from the list of SRMA's that did not incorporate CTR searches and searched ClinicalTrials.gov for unpublished, completed CTR's with relevant outcomes.

RESULTS:
Of 761 papers, 22/761 searched CTR's, meaning only 2.8% of SRMA's in these journals included CTR data. Among 100 randomized papers in secondary analysis, 39% had relevant CTR data, and 16 of those 39 papers had multiple sets of data relevant to the study (41%). Meanwhile, papers published by Cochrane had 69 of 72 reviews (95.8%) that included CTR searches.

CONCLUSION:
This shows that the top neurosurgery journals seldom published SRMA's containing searches for unpublished CTR's while Cochrane almost always had searches. In addition, 41% of the randomized sample in our secondary analysis could have included CTR studies.
STRESS MANAGEMENT IN THE ORGANIZATION OF THE SERVICE SECTOR
Authors: Solovova N. , Kalmykova O. 
Published: September 2022

The article substantiates the importance of methods for preventing stress factors in the organizational environment and increasing the level of stress competence of managers and employees of a service sector organization. The results of sociological research conducted among the personnel of the organization of the service sector are presented. The subject of the study is the methods and personnel activities of stress management at the organizational and personal levels in organizations in the service sector.
The study used diagnostic tools: stress monitoring, which allows assessing the stress factors of the organizational environment; to assess the satisfaction of employees with working conditions and the emotional state of the staff (K.E. Oksinoid); a methodology for assessing the personnel risks of an organization, which makes it possible to build a profile of the organization's personnel risks (Mitrofanova A.E.); peer review method; a method for diagnosing the comfort of the organization's behavioral space (K.E. Oksinoid). In the course of the study, practical recommendations were formed in the field of stress management of the organization of the service sector.
The Changing Role of Human Resources in Organizations and Trends in HRM in the Age of Digitalization
Authors: Babayan Karine 
Published: September 2022

The era of digitalization has brought a new philosophy to the field of human resource management, predetermining a further change in attitudes towards work and the role of a person in an organization.
In this regard, it seems relevant to identify trends in the HRM of organizations in the short term, taking into account the challenges of the digital ecosystem. The article defines the conceptual essence of modern HRM; the positive and negative factors of digitalization of many processes related to HRM, both at the level of each organization and in general for the labor market, were studied; analyzed possible changes in relation to the role of a person and assessed the prospect of employment through the formation of new professions; the main HRM trends of organizations are outlined in the visible future in connection with the introduction of digital technologies.
Prinsip-Prinsip Bahan Tambahan Pangan Yang Memenuhi Syarat Halal: Alternatif Penyedap Rasa Untuk Industri Makanan Halal
Authors: Perdani Claudia , Mawarni Ruli Retno , Mahmudah Liayati , Gunawan Setiyo 
Published: September 2022

Indonesia merupakan negara dengan mayoritas penduduk beragama Islam sekitar 87%, sehingga permintaan produk halal di Indonesia juga cukup besar. Makanan halal merupakan makanan bergizi yang tidak mengandung bahan maupun unsur yang dilarang atau haram untuk dikonsumsi baik bahan baku, bahan tambahan dan bahan penolong, termasuk didalamnya adalah penyedap rasa. Perkembangan industri penyedap rasa makanan di Indonesia terlihat semakin banyak diminati oleh masyarakat. Tujuan dari review ini adalah untuk meringkas prinsip-prinsip dasar memproduksi penyedap rasa serta memahami titik kendali dalam produksi penyedap rasa agar dapat meningkatkan jangkauan produk makanan halal. Dengan adanya informasi ini diharapkan dapat menjadi panduan dalam menentukan penyedap rasa yang sesuai dengan kebutuhan produk dan dapat memenuhi persyaratan kehalalan yang berlaku di Indonesia. Penyedap rasa dapat dibuat melalui berbagai proses baik enzimatis, kimiawi maupun sintesis mikroorganisme, dimana dalam review ini disajikan daftar titik kritis halal penyedap rasa dari setiap proses. Konsumen muslim sebaiknya memperhatikan apakah penyedap rasa tersebut berbasis hewani atau nabati, jika berbasis hewani maka harus memperhatikan sumber hewannya apakah berasal dari hewan yang halal dan proses penyembelihannya sesuai kaidah islam. Sedangkan untuk bahan nabati relatif lebih minim untuk titik kritisnya. Untuk penyedap rasa berbasis proses enzimatis dan hasil sintesis mikroorganisme sebaiknya dipilih yang telah memiliki sertifikat halal, komponen tersebut harus berasal dari sumber yang halal.
Three weeks of rehabilitation improves walking capacity but not daily physical activity in patients with multiple sclerosis with moderate to severe walking disability
Authors: Kuendig Sandra , Kool Jan , Polhemus Ashley , Schallert Wolfgang , Bansi Jens , Gonzenbach Roman Rudolf 
Published: September 2022

Background
Patients with multiple sclerosis have low levels of physical activity. This is of concern because low activity levels are related to cardiovascular disease, poor walking ability, and reduced quality of life. The aim of this study was to evaluate the impact of rehabilitation on daily physical activity and walking capacity in patients with multiple sclerosis who have moderate to severe walking disability.

Methods
This exploratory, observational study of 24 patients with multiple sclerosis examined daily physical activity, walking capacity and fatigue before and after 3 weeks of inpatient rehabilitation. Inpatient rehabilitation included physiotherapy (30–60 min, 5 times/week), strength and endurance training (30–45 min, 3–5 times/week), occupational therapy (30 min, 2–3 times/week), and neuropsychological training (30 min, 2 times/week). There were no specific interventions to target daily levels of physical activity.

Results
Daily physical activity did not change after rehabilitation (physical activity: effect size = –0.23, 95% confidence interval (95% CI) 0.02‒0.62). There were significant improvements in walking capacity (Two-Minute Walk Test: effect size = 0.74, 95% CI 0.31‒1.16, +17 m, 20.2%) and mobility (Timed Up and Go Test: effect size = 0.65, 95% CI 0.22‒1.07, ‒2.1 s, 14.9%). Motor and cognitive fatigue (Fatigue Scale for Motor: effect size = 0.56, 95% CI 0.14‒0.99 and Cognitive Functions: effect size = 0.44, 95% CI 0.01‒0.86) improved significantly after rehabilitation.

Conclusion
Three weeks of rehabilitation improved walking capacity, but not daily physical activity, in patients with multiple sclerosis with moderate to severe walking disability. To increase physical activity, it may be necessary to add specific behavioural interventions to the rehabilitation programme. The intervention plan should include strategies to overcome personal and environmental barriers.
Spatiotemporal variation of malaria incidence in parasite clearance interventions and non-intervention areas in the Amhara Regional State, Ethiopia
Authors: Zeleke Melkamu Tiruneh , Gelaye Kassahun Alemu , Yenesew Muluken Azage 
Published: September 2022

Background
In Ethiopia, malaria remains a major public health problem. To eliminate malaria, parasite clearance interventions were implemented in six kebeles (the lowest administrative unit) in the Amhara region. Understanding the spatiotemporal distribution of malaria is essential for targeting appropriate parasite clearance interventions to achieve the elimination goal. However, little is known about the spatiotemporal distribution of malaria incidence in the intervention and non-intervention areas. This study aimed to investigate the spatiotemporal distribution of community-based malaria in the intervention and non-intervention kebeles between 2013 and 2018 in the Amhara Regional State, Ethiopia.

Methods
Malaria data from 212 kebeles in eight districts were downloaded from the District Health Information System2 (DHIS2) database. We used Autoregressive integrated moving average (ARIMA) model to investigate seasonal variations; Anselin Local Moran’s I statistical analysis to detect hotspot and cold spot clusters of malaria cases; and a discrete Poisson model using Kulldorff scan statistics to identify statistically significant clusters of malaria cases.

Results
The result showed that the reduction in the trend of malaria incidence was higher in the intervention areas compared to the non-intervention areas during the study period with a slope of -0.044 (-0.064, -0.023) and -0.038 (-0.051, -0.024), respectively. However, the difference was not statistically significant. The Global Moran’s I statistics detected the presence of malaria clusters (z-score = 12.05; p<0.001); the Anselin Local Moran’s I statistics identified hotspot malaria clusters at 21 locations in Gendawuha and Metema districts. A statistically significant spatial, temporal, and space-time cluster of malaria cases were detected. Most likely type of spatial clusters of malaria cases (LLR = 195501.5; p <0.001) were detected in all kebeles of Gendawuha and Metema districts. The temporal scan statistic identified three peak periods between September 2013 and November 2015 (LLR = 8727.5; p<0.001). Statistically significant most-likely type of space-time clusters of malaria cases (LLR = 97494.3; p<0.001) were detected at 22 locations from June 2014 to November 2016 in Metema district.

Conclusion
There was a significant decline in malaria incidence in the intervention areas. There were statistically significant spatiotemporal variations of malaria in the study areas. Applying appropriate parasite clearance interventions is highly recommended for the better achievement of the elimination goal. A more rigorous evaluation of the impact of parasite clearance interventions is recommended.
The effect of footwear on mechanical behaviour of the human ankle plantar-flexors in forefoot runners
Authors: Bonacci Jason , Spratford Wayne , Kenneally-Dabrowski Claire , Trowell Danielle , Lai Adrian 
Published: September 2022

Purpose
To compare the ankle plantar-flexor muscle-tendon mechanical behaviour during barefoot and shod forefoot running.

Methods
Thirteen highly trained forefoot runners performed five overground steady-state running trials (4.5 ± 0.5 m.s-1) while barefoot and shod. Three-dimensional kinematic and ground reaction force data were collected and used as inputs for musculoskeletal modelling. Muscle-tendon behaviour of the ankle plantar-flexors (soleus; medial gastrocnemius; and lateral gastrocnemius) were estimated across the stance phase and compared between barefoot and shod running using a two-way multivariate analysis of variance.

Results
During barefoot running peak muscle-tendon unit (MTU) power generation was 16.5% (p = 0.01) higher compared to shod running. Total positive MTU work was 18.5% (p = 0.002) higher during barefoot running compared to shod running. The total sum of tendon elastic strain energy was 8% (p = 0.036) greater during barefoot compared to shod running, however the relative contribution of tendon and muscle fibres to muscle-tendon unit positive work was not different between conditions.

Conclusion
Barefoot forefoot running demands greater muscle and tendon work than shod forefoot running, but the relative contribution of tendon strain energy to overall muscle-tendon unit work was not greater.
A predictor model of treatment resistance in schizophrenia using data from electronic health records
Authors: Kadra-Scalzo Giouliana , Fonseca de Freitas Daniela , Agbedjro Deborah , Francis Emma , Ridler Isobel , Pritchard Megan , Shetty Hitesh , Segev Aviv , Casetta Cecilia , Smart Sophie E. , Morris Anna , Downs Johnny , Christensen Søren Rahn , Bak Nikolaj , Kinon Bruce J. , Stahl Daniel , Hayes Richard D. , MacCabe James H. 
Published: September 2022

ObjectivesTo develop a prognostic tool of treatment resistant schizophrenia (TRS) in a large and diverse clinical cohort, with comprehensive coverage of patients using mental health services in four London boroughs.MethodsWe used the Least Absolute Shrinkage and Selection Operator (LASSO) for time-to-event data, to develop a risk prediction model from the first antipsychotic prescription to the development of TRS, using data from electronic health records.ResultsWe reviewed the clinical records of 1,515 patients with a schizophrenia spectrum disorder and observed that 253 (17%) developed TRS. The Cox LASSO survival model produced an internally validated Harrel’s C index of 0.60. A Kaplan-Meier curve indicated that the hazard of developing TRS remained constant over the observation period. Predictors of TRS were: having more inpatient days in the three months before and after the first antipsychotic, more community face-to-face clinical contact in the three months before the first antipsychotic, minor cognitive problems, and younger age at the time of the first antipsychotic.ConclusionsRoutinely collected information, readily available at the start of treatment, gives some indication of TRS but is unlikely to be adequate alone. These results provide further evidence that earlier onset is a risk factor for TRS.
Impact of systematic medication review in emergency department on patients’ post-discharge outcomes—A randomized controlled clinical trial
Authors: Nymoen Lisbeth Damlien , Flatebø Trude Eline , Moger Tron Anders , Øie Erik , Molden Espen , Viktil Kirsten Kilvik 
Published: September 2022

IntroductionThe main objective of this study was to investigate whether systematic medication review conducted by clinical pharmacists can impact clinical outcomes and post-discharge outcomes for patients admitted to the emergency department.MethodThis parallel group, non-blinded, randomized controlled trial was conducted in the emergency department, Diakonhjemmet Hospital, Oslo, Norway. The study was registered in ClinicalTrials.gov, Identifier: NCT03123640 in April 2017. From April 2017 to May 2018, patients ≥18 years were included and randomized (1:1) to intervention- or control group. The control group received standard care from emergency department physicians and nurses. In addition to standard care, the intervention group received systematic medication review including medication reconciliation conducted by pharmacists, during the emergency department stay. The primary outcome was proportion of patients with an unplanned contact with hospital within 12 months from inclusion stay discharge.ResultsIn total, 807 patients were included and randomized, 1:1, to intervention or control group. After excluding 8 patients dying during hospital stay and 10 patients lacking Norwegian personal identification number, the primary analysis comprised 789 patients: 394 intervention group patients and 395 control group patients. Regarding the primary outcome, there was no significant difference in proportion of patients with an unplanned contact with hospital within 12 months after inclusion stay discharge between groups (51.0% of intervention group patients vs. 53.2% of control group patients, p = 0.546).ConclusionAs currently designed, emergency department pharmacist-led medication review did not significantly influence clinical- or post-discharge outcomes. This study did, however pinpoint important practical implementations, which can be used to design tailored pharmacist-led interventions and workflow regarding drug-related issues in the emergency department setting.
Area of focus to handle delays related to maternal death in Ethiopia
Authors: Tesfay Neamin , Tariku Rozina , Zenebe Alemu , Mohammed Fetiya , Woldeyohannes Fitsum 
Published: September 2022

BackgroundMaternal delay factors, together with medical factors, have a substantial role in determining maternity outcomes. Although several studies were conducted on delay factors that contribute to maternal death in Ethiopia, the studies were mostly focused either on an individual or at a provincial level factor with a limited number of study participants. In response to this gap, this study is aimed at exploring the magnitude and factors related to delay factors that contribute to maternal death in Ethiopia.MethodsThe study used maternal death surveillance data collected from different regions of Ethiopia, compiled between 2013 and 2021. A total of 4530 maternal deaths were reviewed during the study period. A Multilevel multinomial logistic regression model was applied to examine factors associated with delays related to maternal death. An adjusted relative risk ratio with a 95% confidence interval was stated and variables with p-values less than 0.05 were declared as significant predictors of maternal delay.ResultDelay three (delay in receiving adequate and appropriate care once reached a health facility) has contributed to 36.3% of maternal deaths followed by delay one (delay in deciding to seek care when experiencing an obstetric emergency) and delay two (delay in reaching to an appropriate obstetric facility) where each of them contributed to 36.1% and 27.6% of maternal deaths respectively. In the multivariate multilevel multinomial model, maternal age, education status, and place of death were among the individual level factors associated with both delay two and delay three. Conversely, marital status and ANC follow-up were associated with delay two alone, while the timing of maternal death was associated with delay three. Residence and type of facility were provincial-level factors linked with both delay two and delay three, while the type of region was related to delay three of maternal death.ConclusionBoth delay one and three have a major contribution to maternal death in Ethiopia. Individual and provincial level factors played an important role in determining delays related to maternal death. Therefore, it is crucial to account for measures that provide emphasis on the area of raising awareness on the utilization of Antenatal care (ANC) service, improving facility readiness to handle obstetrics emergencies, and narrowing down inequality among regions in service provision.
Spectacle and Diversity: Transnational Media and Global Culture, Lee Artz (2022)
Authors: Mututa Addamms 
Published: September 2022

Review of: Spectacle and Diversity: Transnational Media and Global Culture, Lee Artz (2022)
London and New York: Routledge, 260 pp.,
ISBN 978-0-36775-417-4, e-book, £31.49
The Analytical Onomasticon Project
Authors: McCarty Willard 
Published: September 2022

As Russ Wooldridge pointed out many years ago, all too often “the computer disappears into the background” once its results are to hand (http://projects.chass.utoronto.ca/chwp/). This is especially true if those results fall short of expectations. In the following I describe the history of a project whose failure in those terms turned out to be far more important than its impossible success would have been. The moral of this story is that with persistence the futile struggle to conform works of the imagination to finite, algorithmic requirements is, or can be, transformational. To quote Italo Calvino, the encoder plays a game that if played long, hard, and well enough “finds itself invested with an unexpected meaning [. . .] slipped in from another level” (1980/1966, §4).
Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments
Authors: Jin Shenghao , Jiang Haitao , Sun Yue , Li Fang , Xia Jianglan , Li Yaxin , Zheng Jiwei , Qin Ying 
Published: September 2022

Abstract
Periodontitis is a common disease that is difficult to treat, and if not controlled in time, it causes severe conditions, such as alveolar bone resorption and tooth loosening and loss. Periodontal ligament stem cells constitute a promising cell source for regenerative treatment of periodontitis due to their high osteogenic differentiation capacity. PDLSC osteogenesis plays a central role in periodontal regeneration through successive cytokine-mediated signaling pathways and various biochemical and physicochemical factors. However, this process is inhibited in the inflammatory periodontitis environment due to high concentrations of lipopolysaccharide. Here, we review the mechanisms that influence the osteogenic differentiation of periodontal stem cells in this inflammatory microenvironment.