bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmission of yellow fever vaccine virus from breast feeding mothers to their infants: reporting of yellow fever virus (YFV) RNA detection in milk specimens
Authors: Hassan Tarteel , Bashir Razan A. , Abdelrahman Dina N. , Madni Hassan , M El Hussein Abdel Rahim , Elkidir Isam M. , Enan Khalid A. 
Published: March 2022

Background: Because of yellow fever’s serious impact on health, vaccination is the principal strategy to control the disease. Administration of the yellow fever vaccine to breastfeeding women should be before they complete 9 months post-delivery, in order to prevent transmission of the yellow fever vaccine virus to their infants through breast feeding. This study aimed to confirm whether the excretion of yellow fever vaccine virus is in milk of vaccinated breastfeeding mothers and to confirm the probable transmission to their infants through breast milk. Methods: Samples were taken as follows: one serum specimen was taken 3-14 days after the date of the vaccination, and breast milk specimens were taken at four different time points between 3-4 days apart. Specimens were obtained from eight nursing mothers, who received the YVF vaccine (17DD). Mothers were asymptomatic before and after the vaccine administration but their infants developed symptoms after administration. Maternal serum samples were tested for YFV specific IgM antibodies through immuno-fluorescent assay (IFA). RNA was extracted from serum and breast milk specimens and YFV RNA screened using real-time polymerase chain reaction (RT-PCR). Results: In total, five mothers (62.5%) were positive for YFV IgM and two mothers (25%) had YFV RNA in serum. Among milk specimens, YFV RNA was detected during the four different mentioned collection times as follows (positive milk specimens/total milk specimens): 3/8 (37.5 %), 4/6 (66.6%) and 1/4(25%). RNA was completely undetectable in the last collection time. Conclusions: YFV transmission from mothers to their babies through breast-feeding was highly probable indicated by the temporal relationship to mother’s YF vaccination.
Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in hematologic malignancies: a living systematic review (protocol)
Authors: Leache Leire , Gutiérrez Valencia Marta , Saiz Luis Carlos , Erviti Juan , Rojas Reyes Maria Ximena 
Published: March 2022

Objective: To determine the efficacy and safety of CAR-T therapy in the treatment of patients with hematologic malignancies, in comparison with other current therapies. Design: A living systematic review. Methods: We will include randomized trials evaluating the effect of CAR-T therapy versus other active treatments, hematopoietic stem cell transplantation, best supportive care or any other intervention in patients with hematologic malignancies. Non-randomized primary studies will be searched in case we found no direct evidence from randomized controlled trials. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. Efficacy measures will include overall survival rate, overall response rate, complete response/remission (CR) rate, partial response/remission (PR) rate, relapse from CR, progression-free survival, and time from CAR-T infusion to transplantation. Safety measures will include serious adverse events, the incidence of cytokine release syndrome, graft-versus-host disease, neurotoxicity, and total adverse events. Quality of life will also be assessed. Meta-analyses will be carried out to summarize the results. We will apply the GRADE approach to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available until there is solid evidence to respond to the review objective. We will resubmit it for publication every time the conclusions change or whenever there are substantial updates.
Use of abandoned buildings by mammals in tropical forest sites with no forest control
Authors: Lorenzo Consuelo , Lorenzo-Monterrubio Carmen , Bolaños Jorge E. , Tapia-Ramírez Gloria 
Published: March 2022

Las especies de mamíferos pueden proliferar en una serie de edificaciones abandonadas construidas en sitios de selva mediana perennifolia. Se evaluó la fauna silvestre que colonizó las edificaciones del Parqueológico de la Flora y la Fauna Tropicales “Ingeniero José Narciso Rovirosa” (PFFT) en el municipio Emiliano Zapata, Tabasco, México; sitio abandonado desde hace más de 3 décadas. Colocamos trampas para roedores y redes para murciélagos en 2019 y 2021 dentro de las instalaciones del PFFT. El sitio está actualmente embebido por el crecimiento de selva mediana perennifolia, pastizales y acahuales (estado sucesional de selva mediana perennifolia). Adicionalmente, se realizaron observaciones de especies de mamíferos en los caminos de acceso y dentro de las edificaciones abandonadas. Se registraron 22 especies de mamíferos terrestres, con la mayor tasa de captura de murciélagos, seguida de roedores, en selva mediana perennifolia, pastizales y acahuales. Se observaron ejemplares de los órdenes Didelphimorphia, Carnivora, Cingulata, Primates y Lagomorpha en selva mediana perennifolia. Dos especies están enlistadas en algún estado de conservación, en listados nacionales e internacionales. El PFFT es actualmente un área donde coexisten diversas especies de mamíferos en un ambiente tropical. Las especies de mamíferos registradas se consideran localmente abundantes y fueron registradas en edificaciones rodeadas de diferentes tipos de cobertura vegetal. En este trabajo se muestra el reclamo de una comunidad de mamíferos típicos de la selva mediana perennifolia en sitios con edificaciones abandonadas y en proceso de recolonización por flora nativa.
The association between striae gravidarum and perineal lacerations during labor
Authors: Matyashov Tamar , Pardo Ella , Rotem Reut , Lichtman Yael , Elnir Katz Maayan , Weintraub Adi Y. , Horev Amir 
Published: March 2022

Objective
Striae gravidarum (SG) and perineal lacerations are common occurrences during late pregnancy and labor. It has been hypothesized that both conditions may share a common pathophysiological pathway through changes in the connective tissue. We aimed to investigate a possible association between these two conditions and whether the presence of SG may predict perineal lacerations.

Methods
We conducted a prospective cohort study that included women who gave birth at the Soroka University Medical Center (SUMC), Beer-Sheva, Israel. Those who provided informed consent were examined for the presence of SG using the Davey scoring system to determine the severity of abdominal SG. Clinical and obstetrical characteristics and the presence and degree of perineal tears were retrieved from the computerized patients’ records. Univariate analysis was carried using appropriate statistical tests.

Results
A total of 187 women were recruited. Of those, 81 (43.3%) did not have SG, 24 (12.8%) 43 (23%) and 39 (20.9%) had mild, moderate and severe SG, respectively. Women with SG were significantly older and had a higher body mass index (p<0.01 for both). Delivery characteristics, mode of delivery, and gestational age were comparable between the groups; however, women with SG gave birth to significantly larger neonates (p<0.01). Seventy-one (31%) women had suffered from 1st or 2nd-degree perineal tears, and none had 3rd or 4th-degree perineal tears. No significant differences were found in rates of perineal tears between women with and without SG (p = 0.91), regardless of SG severity (p = 0.38).

Conclusions
In our study, SG was not associated with perineal tears. This information may be used as reassurance when giving antepartum consultation to women with SG, even in severe cases.
Beyond the mother-child dyad: Is co-residence with a grandmother associated with adolescent girls’ family planning knowledge?
Authors: Zevallos-Roberts Emilia , Cunningham Kenda , Adhikari Ramesh Prasad , Thapa Basant , Sear Rebecca 
Published: March 2022

Background
In South Asian countries, adolescent girls are generally embedded in multigenerational households. Nevertheless, public health research continues to focus on the nuclear family and overlook the role of grandmothers in adolescent socialization and the transfer of health information. This study compares family planning knowledge of adolescent girls in households with and without a resident grandmother. Two main types of family planning knowledge were assessed: (1) modern contraceptive knowledge and (2) healthy timing and spacing of pregnancy knowledge.

Methods
This study is a secondary data analysis of the 2017 Suaahara II cross-sectional survey in 16 of Nepal’s 77 districts. Family planning knowledge among 769 adolescent girls was assessed and compared between those living with a grandmother (n = 330) and those not living with a grandmother (n = 439). An analysis of the relationship between co-residence and family planning knowledge was carried out using multivariate logistic regression, adjusting for potential confounders and clustering. Additionally, we used the same method to analyze the association between grandmothers’ family planning knowledge and that of co-resident adolescents.

Results
The odds of correct adolescent modern family planning knowledge were 1.81 (95% CI = 1.27,2.58) times higher in households with a grandmother. The study also identified higher odds of adolescent knowledge of modern contraceptives in households where grandmothers also had correct knowledge (OR 2.00, 95%, CI = 0.97,4.11), although this association was not statistically significant at the 0.05 alpha level. There was insufficient evidence to support the association between grandmother’s co-residency and correct adolescent knowledge of the healthy timing and spacing of pregnancy.

Conclusion
This study provides support for expanding adolescent reproductive health to include the role of senior women in promoting and transmitting health care knowledge to younger women in the household.
Cardiopulmonary, metabolic, and perceptual responses during exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Multi-site Clinical Assessment of ME/CFS (MCAM) sub-study
Authors: Cook Dane B. , VanRiper Stephanie , Dougherty Ryan J. , Lindheimer Jacob B. , Falvo Michael J. , Chen Yang , Lin Jin-Mann S. , Unger Elizabeth R. ,   The MCAM Study Group
Published: March 2022

Background
Cardiopulmonary exercise testing has demonstrated clinical utility in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, to what extent exercise responses are independent of, or confounded by, aerobic fitness remains unclear.

Purpose
To characterize and compare exercise responses in ME/CFS and controls with and without matching for aerobic fitness.

Methods
As part of the Multi-site Clinical Assessment of ME/CFS (MCAM) study, 403 participants (n = 214 ME/CFS; n = 189 controls), across six ME/CFS clinics, completed ramped cycle ergometry to volitional exhaustion. Metabolic, heart rate (HR), and ratings of perceived exertion (RPE) were measured. Ventilatory equivalent (V˙E/V˙O2, V˙E/V˙CO2), metrics of ventilatory efficiency, and chronotropic incompetence (CI) were calculated. Exercise variables were compared using Hedges’ g effect size with 95% confidence intervals. Differences in cardiopulmonary and perceptual features during exercise were analyzed using linear mixed effects models with repeated measures for relative exercise intensity (20–100% peak V˙O2). Subgroup analyses were conducted for 198 participants (99 ME/CFS; 99 controls) matched for age (±5 years) and peak V˙O2 (~1 ml/kg/min-1).

Results
Ninety percent of tests (n = 194 ME/CFS, n = 169 controls) met standard criteria for peak effort. ME/CFS responses during exercise (20–100% peak V˙O2) were significantly lower for ventilation, breathing frequency, HR, measures of efficiency, and CI and significantly higher for V˙E/V˙O2, V˙E/V˙CO2 and RPE (p<0.05adjusted). For the fitness-matched subgroup, differences remained for breathing frequency, V˙E/V˙O2, V˙E/V˙CO2, and RPE (p<0.05adjusted), and higher tidal volumes were identified for ME/CFS (p<0.05adjusted). Exercise responses at the gas exchange threshold, peak, and for measures of ventilatory efficiency (e.g., V˙E/V˙CO2nadir) were generally reflective of those seen throughout exercise (i.e., 20–100%).

Conclusion
Compared to fitness-matched controls, cardiopulmonary responses to exercise in ME/CFS are characterized by inefficient exercise ventilation and augmented perception of effort. These data highlight the importance of distinguishing confounding fitness effects to identify responses that may be more specifically associated with ME/CFS.
Association between low levels of HIV-1 DNA and HLA class I molecules in chronic HIV-1 infection
Authors: Muccini Camilla , Guffanti Monica , Spagnuolo Vincenzo , Cernuschi Massimo , Galli Laura , Bigoloni Alba , Galli Andrea , Poli Andrea , Racca Sara , Castagna Antonella 
Published: March 2022

BackgroundHLA-B27 and -B57 were found in people with low levels of HIV-1 DNA, suggesting that HLA class I molecules may influence the size of HIV-1 reservoir. Aim of the study was to explore the association between HLA class I molecules and HIV-1 DNA in people with chronic HIV-1 infection.MethodsPost-hoc analysis of the APACHE trial, on adults with chronic HIV-1 infection, prolonged suppressive antiretroviral therapy and good immunological profile. HIV-1 DNA was quantified in peripheral blood mononuclear cells (PBMCs); HLA-A, -B and -C were tested on genomic DNA. Crude odds ratios (OR) with their respective 95% Wald confidence intervals (95% CIs) were estimated by univariable logistic regression for HLAs with a p-value <0.10.ResultsWe found 78 and 18 patients with HIV-1 DNA ≥100 copies/106PBMCs and with HIV-1 DNA <100 copies/106PBMCs, respectively. HLA-A24 was present in 21 (29.6%) participants among subjects with HIV-1 DNA ≥100 copies/106PBMCs and 1 (5.9%) among those with HIV-1 DNA <100 copies/106PBMCs (OR = 5.67, 95%CI = 0.79–46.03; p = 0.105); HLA-B39 was present in 1 (1.4%) with HIV-1 DNA ≥100 copies/106PBMCs and in 3 (17.6%) with HIV-1 DNA <100 copies/106PBMCs (OR = 13.71, 95%CI = 1.33–141.77; p = 0.028) and HLA-B55 in 3 (4.2%) and 3 (17.6%), respectively (OR = 4.43, 95%CI = 0.81–24.29; p = 0.087). All the three patients with HLA-B39 and HIV-1 DNA <100 copies/106PBMCs did not have HLA-A24.ConclusionsIn patients with HIV-1 infection who maintained a good virological and immunological profile, HLA-B39 and -B55 may be associated with lower levels of HIV-1 DNA.
Process model correlating Athabasca bitumen thermally cracked at edge of coking induction zone
Authors: Remesat Darius 
Published: March 2022

Abstract
Athabasca bitumen is an abundant resource that has successfully been upgraded using delayed coking that typically operates at 499 °C (∼930 °F), 207 kPa (∼37 psig), 1–2 min residence time on this type of crude. With society’s desire to reduce industry environmental impact while still providing energy to earth’s growing population, lower energy intensive (and thus lower greenhouse gas emissions) bitumen conversion approaches have been researched and are moving towards commercialization. The paper reviews a correlative model developed on a novel thermal cracking process, operated at lower temperatures (395–405 °C (743–761 °F)), lower pressures (<69 kPa (∼<10 psig) and up to 1 h residence time versus delayed coking, that takes various lab and pilot data, both batch and continuous, as inputs into developing the model. The purpose of the model is for use in industrial operations to provide guidance to operations for representative thermal cracker performance. The model is based on the Arrhenius equation using first order reaction kinetics for easy comprehension and use in an operational environment. Data for developing the model has been taken from various literature sources in the area of study, notably by researchers, Dr. W. Svrcek, Dr. Wiehe, Dr. Mehrotra, and Dr. Yarranton. The public data is used to create a viable range of performance that includes proprietary developments with the novel thermal cracking process. The model is configured on a mass basis so that mass balance closure can be readily calculated. A range of kinetic coefficients are provided that can be used to fit commercial plant performance based on the expected range of product outputs noted in the paper.
Pelvic abscess associated with Actinomyces species ‒ a rare post-cesarean complication
Authors: Wang Yuping , Ferrero Simone , Li Shasha , Liu Shisan , Yang Wah 
Published: March 2022

Abstract

Objectives
Pelvic actinomycotic abscess is uncommon and its presentation as a post-cesarean complication may be confused with hemorrhagic mass. It is still a disease that poses a significant diagnostic challenge. Management and prognosis are not well known for this type of infection.

Case presentation
A 36-year-old woman was admitted to the hospital six days after the cesarean section with abdominal pain and dysuria. The second operation was diagnosed as pelvic abscess, debridement and drainage about 250 mL abscess. Bacterial culture of abscess confirmed as Actinomyces odontolyticus infection. Intravenous penicillin was given immediately, amoxicillin was taken orally for three months after discharge, and no recurrence was found after follow-up for ten months.

Conclusions
Pelvic A. odontolyticus abscess may be confirmed through correct bacterial culture and cured by a short-term course of Amoxicillin. With prompt recognition and treatment, favorable outcomes of pelvic Actinomycotic abscess in the perinatal period could be achieved.
Fujirebio Lumipulse SARS-CoV-2 antigen immunoassay: pooled analysis of diagnostic accuracy
Authors: Lippi Giuseppe , Henry Brandon M. , Adeli Khosrow , Plebani Mario 
Published: March 2022

Abstract
We provide here a pooled analysis of accuracy of Fujirebio Lumipulse SARS-CoV-2 Antigen chemiluminescent immunoassay for diagnosing acute SARS-CoV-2 infections. An electronic search was conducted in Scopus and Medline with the keywords “Lumipulse” AND “antigen” AND “SARS-CoV-2” or “COVID-19”, up to January 21, 2022, for identifying clinical investigations (minimum sample size ≥100) where diagnostic accuracy of Lumipulse G SARS-CoV-2 Ag was tested against reference molecular techniques. All studies which allowed to construct a 2 × 2 table were included in a pooled analysis. A final number of 21 studies, totalling 17,648 nasopharyngeal and 8538 saliva specimens, were finally included. The pooled diagnostic sensitivity and specificity in nasopharyngeal swabs were 0.80 (95%CI, 0.78–0.81) and 0.98 (95%CI, 0.97–0.98), respectively, whilst the area under the curve and agreement were 0.980 (95%CI, 0.973–0.986) and 94.9%, respectively. In the twelve studies which used the fixed 1.34 pg/mL currently recommended manufacturer’s threshold, the diagnostic accuracy remained unvaried. In saliva samples, the pooled diagnostic sensitivity and specificity were 0.75 (95%CI, 0.71–0.75) and 1.00 (95%CI, 0.99–1.00), respectively, whilst the area under the curve and were 0.976 (95%CI, 0.969–0.984) and 98.4%, respectively. In the five studies which used the fixed 0.67 pg/mL currently recommended manufacturer’s threshold, the diagnostic accuracy remained unvaried. In conclusion, Lumipulse G SARS-CoV-2 Ag assay demonstrates good diagnostic sensitivity and specificity, thus representing a valuable complementary and integrative option to molecular testing for SARS-CoV-2 in the current pandemic.
An FCM clustering algorithm based on the identification of accounting statement whitewashing behavior in universities
Authors: Yang Qihao 
Published: March 2022

Abstract
The traditional recognition method of whitewash behavior of accounting statements needs to analyze a large number of special data samples. The learning rate of the algorithm is low, resulting in low recognition accuracy. To solve the aforementioned problems, this article proposes a method to identify the whitewash behavior of university accounting statements based on the FCM clustering algorithm. This article analyzes the motivation of university accounting statement whitewashing behavior, studies the common means of statement whitewashing, and establishes a fuzzy set for the identification of university accounting statement whitewashing behavior. By calculating the fuzzy partition coefficient, the membership matrix of whitewash behavior recognition is established, and the whitewash behavior is classified through the iteration of the FCM algorithm. The comparative experimental results show that the recognition method has good recognition performance, low recognition error rate, and recognition accuracy of 82%.
Independent qualification of the CIAU tool based on the uncertainty estimate in the prediction of the LOBI test A1-93
Authors: Borges R. C. , Auria F.D’ , Alvim A. C. M. 
Published: March 2022

Abstract
The Code with – the capability of – Internal Assessment of Uncertainty (CIAU) is a tool proposed by the Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione (DIMNP) of the University of Pisa. Other Institutions including the nuclear regulatory body from Brazil, “Comissäo Nacional de Energia Nuclear”, contributed to the development of the tool. The CIAU aims at providing the currently available Relap5/Mod3.2 system code with the integrated capability of performing not only relevant transient calculations but also the related estimates of uncertainty bands. The Uncertainty Methodology based on Accuracy Extrapolation (UMAE) is used to characterize the uncertainty in the prediction of system code calculations for light water reactors and is ‘internally’ coupled with the above system code. Following an overview of the CIAU development, the present paper deals with the independent qualification of the tool. The qualification test is performed by estimating the uncertainty bands that should envelope the prediction of the LOBI test Al-93 (small break loss of coolant accident). The current limitation of the ‘error’ database, implemented into the CIAU prevented a final demonstration of the qualification. However, all the steps for the qualification process are demonstrated.
Uncertainty and sensitivity analysis with respect to the hydrogen production determined by MELCOR 1.8.4 code during a severe accident
Authors: Kronenberg J. 
Published: March 2022

Abstract
For the selection and design of measures to scope with the hydrogen which will be produced in the course of a severe accident in LWRs a simple postulate – e. g. 75 % zircaloy oxidation of all fuel rod claddings – is not appropriate. In our opinion, realistic (best estimate) analyses with indication of the uncertainties are substantially more suitable. However, the problem thereby lies in the determination of these uncertainties. The current work presents a method, which determines the uncertainty band for the in-vessel hydrogen production calculated with the MELCOR program using a mathematical-statistic method (SUSA). For the exercise a “Total loss of the alternating current supply” for the planned European Pressurised Water Reactor (EPR) has been chosen as a representative scenario. Besides the actual uncertainties of the computational program concerned with such an analysis also the sensitive parameters can be identified.