bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for and characteristics of community‐ and hospital‐acquired drug‐induced acute kidney injuries
Authors: Rey Amayelle , Gras‐Champel Valérie , Choukroun Gabriel , Masmoudi Kamel , Liabeuf Sophie 
Published: January 2022

AbstractDrugs constitute one of the leading causes of acute kidney injuries (AKIs) and can appear in community (CA‐AKI) or hospital (HA‐AKI) population. The objectives of the present study of a cohort of hospitalized patients with AKI were to describe the characteristics of drug‐induced AKIs and the patients' short‐term outcomes and assess risk factors for drug‐induced AKIs overall, CA‐AKIs, and HA‐AKIs. Based on a cohort of 1557 hospitalized patients suffering from AKIs based on PMSI extraction and chart review (IRA‐PMSI), drug‐induced AKIs were identified by applying the Naranjo adverse drug reaction (ADR) probability scale. Multivariate logistic regression was used to identify factors associated with CA‐AKIs and/or HA‐AKIs. When considering the 1557 patients who experienced an AKI, 445 (28.6%) of the injuries were drug‐induced (180 CA‐AKIs (40.4%) and 265 HA‐AKIs (59.6%)). Antibiotics, diuretics, and contrast agents were significantly more likely to be involved in HA‐AKIs, whereas antineoplastic, lipid‐lowering drugs, antidiabetics, and immunosuppressive were significantly more likely to be involved in CA‐AKIs. Female sex (odds ratio [OR] [95%CI] = 1.3 [1.04–1.67]), chronic kidney disease (CKD) (OR = 1.8 [1.40–2.67]), and a history of ADRs of any type (OR = 1.3 [1.05–1.73]) were significant risk factors for drug‐induced AKIs. CKD was a risk factor for both CA‐AKI and HA‐AKI. In view of the long‐term impact of AKI on the kidneys and the differences between our CA‐AKI and HA‐AKI subgroups, our present results are interesting for optimizing treatments, limiting the occurrence of CA‐ and HA‐AKIs and (ultimately) reducing healthcare costs.
Plant–plant interactions determine taxonomic, functional and phylogenetic diversity in severe ecosystems
Authors: Bashirzadeh Maral , Soliveres Santiago , Farzam Mohammad , Ejtehadi Hamid 
Published: January 2022

AbstractAimPlant–plant interactions are an important factor in structuring plant biodiversity. However, most studies on the impacts of plant–plant interactions on biodiversity focus on species richness and to a lesser extent on other facets of diversity. When other facets of biodiversity are considered, studies often include a limited set of environmental conditions. We aimed to quantify the impacts of nurse plants on taxonomic, functional and phylogenetic facets of plant biodiversity and how these impacts change across environmental gradients.LocationWe report data on 28 alpine and 50 dryland sites, established in 11 countries.Time period1998–2019.Major taxa studiedVascular plants.MethodsWe analysed plant–plant interactions using co‐occurrence analyses and obtained information on the functional traits and phylogenetic relationships of the beneficiary species. We calculated the change in taxonomic, functional and phylogenetic diversity caused by the presence of nurse plants and environmental conditions.ResultsNurse plants enhanced taxonomic and phylogenetic diversity in alpine communities and enhanced functional and phylogenetic diversity in dryland communities. However, they had a positive effect on functional and taxonomic diversity only in moderate environments in alpine and dryland communities, respectively. The effects of nurse plants were larger in drylands for functional and phylogenetic diversity and in alpine communities for taxonomic diversity. Interestingly, nurse plants induced nonlinear changes in all facets of biodiversity across environmental gradients, whereas biodiversity tended to increase linearly toward more benign conditions in open interspaces.Main conclusionsFacilitation is important in alpine environments to maximize taxonomic diversity and has a more consistent positive effect on the functional and phylogenetic diversity of drylands. In general, effects of facilitation on biodiversity peak in moderate environmental conditions, which suggests that nurse plants can protect biodiversity from impacts of climate change mostly in those places currently under low environmental stress and that will be likely to experience moderate stress levels in the future.
Biotic factors limit the invasion of the plague pathogen (Yersinia pestis) in novel geographical settings
Authors: Fell Henry G. , Osborne Owen G. , Jones Matthew D. , Atkinson Steve , Tarr Simon , Keddie Suzanne H. , Algar Adam C. 
Published: January 2022

AbstractAimThe distribution of Yersinia pestis, the pathogen that causes plague in humans, is reliant upon transmission between host species; however, the degree to which host species distributions dictate the distribution of Y. pestis, compared with limitations imposed by the environmental niche of Y. pestis per se, is debated. We test whether the present‐day environmental niche of Y. pestis differs between its native range and an invaded range and whether biotic factors (host distributions) can explain observed discrepancies.LocationNorth America and Central Asia.Major taxa studiedYersinia pestis.MethodsWe use environmental niche models to determine whether the current climatic niche of Y. pestis differs between its native range in Asia and its invaded range in North America. We then test whether the inclusion of information on the distribution of host species improves the ability of models to capture the North American niche. We use geographical null models to guard against spurious correlations arising from spatially autocorrelated occurrence points.ResultsThe current climatic niche of Y. pestis differs between its native and invaded regions. The Asian niche overpredicted the distribution of Y. pestis across North America. Including biotic factors along with the native climatic niche increased niche overlap between the native and invaded models, and models containing only biotic factors performed better than the native climatic niche alone. Geographical null models confirmed that the increased niche overlap through inclusion of biotic factors did not, with a couple of exceptions, arise solely from spatially autocorrelated occurrences.Main conclusionsThe current climatic niche in Central Asia differs from the current climatic niche in North America. Inclusion of biotic factors improved the fit of models to the Y. pestis distribution data in its invaded region better than climate variables alone. This highlights the importance of host species when investigating zoonotic disease introductions and suggests that climatic variables alone are insufficient to predict disease distribution in novel environments.
In lockdown with my inner saboteur: A collaborative collage on self‐compassion
Authors: Lafaire Ana Paula , Soini Aleksi , Grünbaum Leni 
Published: January 2022

AbstractDear reader, we are writing this piece as a collaborative collage based on our experience of our ongoing PhD journey in a “top” business school, on self‐compassion and the inner saboteur, all saturated by the unpredictable developments of the COVID‐19 pandemic. Contrary to the linear argumentation of academic writing, collage writing works by opening up “new possibilities for understanding” what is written (Herrmann, 2020, p. 298). This introduction is where we manage your expectations, by letting you know that what follows below does not replicate the structure or the form of a conventionally organized paper.
Effects of holding time on structure and the properties of spodumene/mullite composite ceramics
Authors: Wu Yaqun , Tian Yuming , Feng Ming , Qing Mei , Wu Yaqiao 
Published: January 2022

AbstractIn this paper, spodumene/mullite ceramics with good thermal shock resistance were prepared from spodumene, quartz, talc, and clay when the sintering temperature was 1270℃. In the sintering process, the effect of holding time on densification, mechanical properties, phase transformation, microstructure, and thermal shock resistance of the composite ceramics were investigated. The phase transition and microstructures of the ceramics were identified via X‐ray diffraction (XRD) and scanning electron microscopy (SEM). The interaction between holding time and bulk density was studied by response surface methodology. The result show that an appropriate holding time can improve the mechanical properties of spodumene/mullite ceramics. When the holding time was kept 90 min, the spodumene/mullite ceramics with the apparent porosity was .47%, the bulk density was 2.28 g/cm3, and bending strength was 63.46 MPa. Furthermore, since no cracks formed after 20 thermal shock cycles for the composite ceramics with a bending strength decreasing rate of 12.66%, it is revealed that spodumene/mullite ceramics exhibit good thermal shock resistance. Therefore, this study can provide beneficial guidance for both industrial production and energy conservation.
Financial market incompleteness and international cooperation on capital controls
Authors: Kitano Shigeto , Takaku Kenya 
Published: January 2022

AbstractWe examine how the degree of financial market incompleteness affects welfare gains from international cooperation on capital controls. When financial markets are incomplete, international risk sharing is disturbed. However, the optimal global policy significantly reverses the welfare deterioration due to inefficient risk sharing. We show that when financial markets are more incomplete, the welfare gap between the optimal global policy and the Nash equilibrium increases, and the welfare gains from international cooperation on capital controls then become larger.
MiR‐3017b contributes to metamorphosis by targeting sarco/endoplasmic reticulum Ca2+ATPase in Tribolium castaneum
Authors: Tang Jing , Zhai Mengfan , Yu Runnan , Song Xiaowen , Feng Fan , Gao Han , Li Bin 
Published: January 2022

AbstractIn recent years, increasing numbers of microRNAs (miRNAs) have been reported to regulate insect metamorphosis. One thousand, one hundred fifty‐four miRNAs have been previously identified from Tribolium castaneum by high‐throughput sequencing; however, little is known about which miRNAs can participate in metamorphosis, leaving the role of miRNAs in regulating the underlying mechanism elusive. Here, we report the participation of miR‐3017b in the metamorphosis of T. castaneum. Temporal profiles revealed that miR‐3017b was highly expressed at the late larval stage, but significantly decreased at the early pupal stage. Overexpression of miR‐3017b caused larval to pupal to adult metamorphosis arrested. Dual‐luciferase reporter assay and miRNA–mRNA interaction assay illustrated that miR‐3017b interacts with the coding sequence of sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) and suppresses its expression. Knockdown of SERCA caused metamorphosis arrested, similar to that observed in miR‐3017b overexpression beetles. Further functional mechanism analyses revealed that 20‐hydroxyecdysone application downregulates miR‐3017b and up‐regulates SERCA expression. The expression level of downstream genes in the 20E pathway was disrupted after overexpressing miR‐3017 and the knockdown of SERCA. These results provided evidence miR‐3017b‐SERCA contributes to metamorphosis by regulating the 20E pathway in T. castaneum. It could advance our understanding of the coordination of 20E and miRNA regulation in insect metamorphosis.
Cortical auditory evoked potentials in 1‐month‐old infants predict language outcomes at 12 months
Authors: Cruz Sara , Crego Alberto , Moreira Carla , Ribeiro Eugénia , Gonçalves Óscar , Ramos Rita , Sampaio Adriana 
Published: January 2022

AbstractThe neurophysiological assessment of infants in their first developmental year can provide important information about the functional changes of the brain and supports the study of behavioral and developmental characteristics. Infants’ cortical auditory evoked potentials (CAEPs) reflect cortical maturation and appear to predict subsequent language abilities. This study aimed to identify CAEP components to two auditory stimulus intensities in 1‐month‐old infants and to understand how these are associated with social interactive and self‐regulatory behaviors. In addition, it examined whether CAEPs predicted developmental outcomes when infants were assessed at 12 months of age. At 1 month, P2 and N2 components were present for both auditory stimulus intensities, with an increased P2 amplitude being observed for the higher‐intensity stimuli. We also observed that an increased P2 amplitude in the lower intensity predicted receptive and expressive language competencies at 12 months. These results are consistent with previous findings indicating an association between auditory processing and developmental outcomes in infants. This study suggests that specific auditory neurophysiological markers are associated with developmental outcomes in the first developmental year.
Deep‐sea clays using as active Fenton catalysts for self‐propelled motors
Authors: Zhang Peiping , Sun Xue , Guo Jiankang , Wang Yan , Zhang Wei , Ning Weikun , Li Wenqing , Wei Cundi , Shi Xuefa , Miao Shiding 
Published: January 2022

AbstractRaw deep‐sea clays (i.e., pelagic clays) collected from the Indian Ocean were able to function as Fenton catalysts and self‐propelled micromotors due to the high content of Fe‐ and Mn‐. The pelagic clays were for the first time observed to be automatic in the H2O2 solution. The pelagic clays existed in the form of poorly crystallized marine sedimentation. The major minerals were found as illite/montmorillonite (I/M) and amorphous ferromanganese nodules, and the minor minerals included kaolinite, quartz, feldspar, and calcite. Significant amounts of oxygen bubbles were generated when the clay particles were dispersed into the H2O2 solution (0.1–10.0 wt.%), and the average velocity of the motors was observed as high as 183.0 μm s–1 in 10.0 wt.% H2O2. The self‐propulsion would induce vigorous mixing in local areas of the solution and was confirmed to benefit the catalytic performance. The clays were employed to remove Rhodamine B (RhB) for a proof‐of‐concept study. In the acid solution (pH = 1.0–5.0), the removal of RhB was controlled by the Fenton process accompanied by the adsorption of clay particles. In the alkaline solution (pH = 9.0), the removal of RhB was found to follow an adsorptive bubble separation pathway. Both processes were greatly influenced by the self‐motion of MnOx motors contained in the pelagic clays.
Unusual pollinator attractants increase the fructification rate on West Indian Cherry Trees
Authors: Suárez Natália Ferreira , Latini Anderson Oliveira , Rufini José Carlos Moraes , Reis Leticia Alves Carvalho , Silva Daniel Paiva , Abreu Rafael Azevedo Arruda , Stein Katharina 
Published: January 2022

AbstractAlthough West Indian Cherry (WIC) trees have abundant flowering, specimens of this species have low fructification rates, potentially associated with the dependence of these plants on pollinators for cross‐pollination and fruit production. We quantified fructification rates and assessed the market value of pollination services by conducting an experiment with six treatments, including manual and open pollination, pollinator exclusion treatment, and open pollination with blue and yellow attractants. The investigation occurred at two sampling periods (November–December 2015 and January–February 2016) in a commercial orchard of WIC in Brazil. Despite the six different treatments in the two sampling periods, the fructification rate only differed in open pollination treatments with colour attractants, increasing the fructification rate between 160% (for blue‐coloured attractants) and 240% (for yellow‐coloured attractants). Considering that yield is directly affected by the increase in the fructification rate, the yield might be enhanced by up to 70 ton/ha by the coloured attractants. Economically speaking, this result means an approximate 130% increase in the earnings for farmers and maybe transferable to other crops contributing to food production and recognizing the importance of biodiversity and associated ecosystem services.
Effect of simulated tootbrushing on surface roughness of sealant agent coupled nanohybrid composite resins
Authors: Halis Gizem , Köroğlu Ayşegül , Şahin Onur , Dede Doğu Ömür , Yilmaz Burak 
Published: January 2022

AbstractObjectiveTo investigate the effect of toothbrushing on the surface roughness (Ra) of different sealant agent coupled nanohybrid composite resins.Materials and MethodsOne hundred sixty disc‐shaped (10 × 2 mm) specimens were prepared from four different nanohybrid composite resins (Z‐550, Tetric EvoCeram, Clearfill Majesty, Ice). Specimen groups were divided into four subgroups for conventional polishing (control) and to apply three different surface sealant agents (Palaseal, Optiglaze, Biscover LV) (n = 10). The Ra values of the specimens were recorded before (Ra0) and after 10,000 cycles of toothbrushing (Ra1). The surface properties of the specimens were evaluated with scanning electron microscope (SEM). Data were statistically analyzed by two‐way analysis of variance (ANOVA), Tukey HSD, and paired sample t tests.ResultsComposite resin material, surface treatment, and their interaction were significant on Ra values (p < 0.001). Significant decrease in Ra0 values observed for surface sealant agent coupled Clearfill Majesty and Tetric EvoCeram composite resin groups compared with the control groups (p < 0.05). After simulated one‐year toothbrushing, the control group of Clearfill Majesty had the highest Ra1 value (p < 0.001). The Ra1 values of all groups were significantly higher than the Ra0 values (p < 0.05).ConclusionsSimulated 1‐year toothbrushing increased the surface roughness of all nanohybrid composite resin materials. Optiglaze and Biscover LV sealant agents on Tetric EvoCeram, and all tested sealant agents on Clearfill Majesty enabled smoother surfaces than conventional polishing after toothbrushing.Clinical SignificanceBecause toothbrushing increases the surface roughness of tested nanohybrid composite resins, the application of surface sealant agents on some of the tested resins can be considered for smoother surfaces.
Myology of the pelvic limb of the brown‐throated three‐toed sloth (Bradypus variegatus)
Authors: Butcher Michael T. , Morgan Dakota M. , Spainhower Kyle B. , Thomas Dylan R. , Chadwell Brad A. , Avey‐Arroyo Judy A. , Kennedy Sarah P. , Cliffe Rebecca N. 
Published: January 2022

AbstractTree sloths rely on their limb flexors for bodyweight support and joint stability during suspensory locomotion and posture. This study aims to describe the myology of three‐toed sloths and identify limb muscle traits that indicate modification for suspensorial habit. The pelvic limbs of the brown‐throated three‐toed sloth (Bradypus variegatus) were dissected, muscle belly mass was recorded, and the structural arrangements of the muscles were documented and compared with the available myological accounts for sloths. Overall, the limb musculature is simplified by containing muscles with generally long and parallel fascicles. A number of specific and informative muscle traits are additionally observed in the pelvic limb ofB.variegatus: well‐developed hip flexors and hip extensors each displaying several fused bellies; massive knee flexors; two heads of the m. adductor longus and m. gracilis; robust digital flexors and flexor tendons; m. tibialis cranialis muscle complex originating from the tibia and fibula and containing a modified m. extensor digitorum I longus; appreciable muscle mass devoted to ankle flexion and hindfoot supination; only m. extensor digitorum brevis acts to extend the digits. Collectively, the findings for tree sloths emphasize muscle mass and organization for suspensory support namely by the hip flexors, knee flexors, and limb adductors, for which the latter two groups may stabilize suspensory postures by exerting appreciable medially‐directed force on the substrate. Specializations in the distal limb are also apparent for sustained purchase of the substrate by forceful digital flexion coupled with strong ankle flexion and supination of the hind feet, which is permitted by the reorganization of several digital extensors. Moreover, the reduction or loss of other digital flexor and ab‐adductor muscles marks a dramatic simplification of the intrinsic foot musculature inB.variegatus, the extent to which varies across extant species of two‐ and three‐toed tree sloths and likely is related to substrate preference/use.
Clinical observation of basic fibroblast growth factor (bFGF) combined with minoxidil in the treatment of male androgenetic alopecia
Authors: Liu Chi , Zhao Hongwei , Zhang Ying , Wu Wei 
Published: January 2022

AbstractBackgroundAndrogenetic alopecia (AGA) has been one of the most common progressive hair loss in the world, which affects 80% of white males. To date, only minoxidil and finasteride have been approved by FDA for the treatment of AGA. However, limited therapeutic effect and the toxic adverse events of these drugs limit their applications. Therefore, it is still an urgent clinical problem to find effective therapeutic drugs and medication regimen.ObjectiveThe goal was to explore the efficacy and side effects of basic fibroblast growth factor (bFGF) combined with minoxidil in the treatment of male patients with early stage of androgenetic alopecia (AGA).MethodsUsing a randomized control method, 80 male patients with androgenetic alopecia in Hamilton grade II–IV were randomly divided into two groups, with 40 patients in each group. The Group A: 1 ml minoxidil for external use twice a day; Group B: 3500 IU basic fibroblast growth factor (bFGF) and 1 ml minoxidil for external use twice a day. The selected patients received global photograph evaluation before treatment, 3 months after treatment, and 6 months after treatment, and the curative effect was judged according to the changes in the area and degree of hair loss on the top of the head and anterior parietal area of the patients shown in the photographs before and after treatment. At the same time, each patient had a satisfaction questionnaire survey before treatment, 3 months after treatment, and 6 months after treatment. During the research period, the adverse reactions of the patients were recorded.ResultsAfter 3 months and 6 months of treatment, the effective rate of the two groups was statistically significant (p < 0.05), and the patients’ hair conditions in the Group B improved significantly compared with those in the Group A. After 6 months of treatment, the difference in treatment satisfaction between the two groups was statistically significant (p < 0.05). The patients in the Group B were more satisfied than those in Group A. During the patient's medication, no serious adverse reactions occurred in the two groups, and the incidence of adverse reactions between the two groups was not statistically significant (p > 0.05).ConclusionCompared with 5% minoxidil alone, the combination of basic fibroblast growth factor (bFGF) +5% minoxidil in the treatment of male patients with early stage of androgenetic alopecia improved treatment efficiency and patient satisfaction.