bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of the Use of Particulate Graft versus Block Bone Graft in Ridge Augmentation: A Hospital Based Retrospective Study
Authors: Abitha S. Tasleem , Jeevitha M. , Jayaraman Selvaraj , Kumar M. Naveen 
Published: February 2022

Aim: To assess the prevalence of the use of particulate graft versus block bone graft in ridge augmentation.
Introduction: Ridge augmentation is a process of replacing the lost bone of residual ridge by grafting natural or synthetic material. Dimensional changes in the alveolar ridge after extraction often compromises on achieving optimal implant stability and placement of implants in the right prosthodontic positions. These situations demand augmentation of the residual ridge to achieve successful implant placement and long-term survival.
Materials and Methods: Case sheets of thirty-eight patients who had underwent ridge augmentation procedure were analysed for the study. The collected data was statistically analysed using chi square test and the results were obtained. SPSS software was used for obtaining the results.
Results and Discussion: Majority of the participants in the study were around the age 15-30 years. Around 74% of the participants have undergone particulate bone graft rather than block bone graft. From the study it is proven that around 81% of the augmentation type are for the hard tissue.
Conclusion: Hence from the study it is proven that particulate graft is more commonly opted than block bone graft.
Comparison of Pre-determined Question Paper with Take Home Question Paper to Evaluate the Efficacy of Writing Skill in Final BDS Student
Authors: Durge Khushboo , Ikhar Anuja , Pathak Swanand , Daigavane Pallavi , Bajaj Pavan 
Published: February 2022

Background: Exams have always been a trigger point of stress and anxiety in a large population of students irrespective to their field of study. An effort should be put to make exams a source of learning rather than a mental trauma. Apart from just securing high scores, exams has a paramount advantages. Exams aid in strong memory confidence, practical implications competitive Spiritand time management. This would definitely contributes to the overall development of an individual’s personality. Therefore, with this hypothesis the current study will be conducted.
Study Design: Cross- sectional observational Study.
Methodology: A total of 100 Final BDS students will be randomly divided into two groups equally. Each group will be including 50 students. Group A will be given Take home exam to write and Group B will be given pre-determined question paper. Students will be asked to solve the given paper in 3 hours. The answer papers will be then evaluated by subject expert. The writing skill would be analysed based on the check list created. At the end of every month feedback will collected by all the students. At the end of the academic year the performances of both the group will evaluated in final university exam. Soon after the writing the paper feedback will be collected
Expected Outcome: At the end of academic session pre-determined question paper (Group B) might be giving better outcome in terms of improved writing skills and feedback from students.
Conclusion: Pre-determined question paper (Group B) might be helpful for Final BDS students to improve writing exam skills.
Synthesis and Biological Activities of (4Z)-2-(1H-benzimidazol-2-ylmethyl)-4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one Compounds
Authors: More Vishal. S. , Mishra Pranali A. , Rangari Nalanda T. , Vaidhun Bhaskar H. , Chavan Machindra J. 
Published: February 2022

Pyrazoles are reported to be well known pharmacophores. This has motivated the synthesize some of the pyrazole derivatives by using hydrazine hydrate as well as adding benzimidazole in pyrazoles. A series of (4Z)-2-(1H-benzimidazol-2-ylmethyl)-4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-ones (IIIa3 to IIIe3) was synthesized by conventional method by refluxing compounds (IIIa2-IIIe2) with O-Phenylene diamine in absolute ethanol. A series of compounds (IIIa2-IIIe2) was prepared by reacting compounds (IIIa1-IIIe1) with chloroacetic acid. A series of (4E)-4-arylidene-5-methyl-2,4–dihydro-3H-pyrazol-3-ones (IIIa1-IIIe1) was prepared by the reaction between 5-methyl-2,4-dihydro- 3H-pyrazol-3-one (II) and different aldehydes in presence of Sodium acetate. All of the compounds were synthesised with high yields (58-80%) and identified using IR, 1H NMR spectrum data, as well as C, H, and N elemental analyses. At varying MIC values, all of the produced compounds showed antibacterial and antifungal activity, as well as analgesic and anti-inflammatory properties. Anticonvulsant, CNS depressive, ulcerogenic, and anthelmintic properties are thought to be exhibited by the produced compounds.
A Study of Glucose Tolerance Test, Body Mass Index and Waist Hip Ratio as a Marker of Pre-Diabetes
Authors: Gokhale Vijayashree S. , Yadav Ponvijaya M. , Parati Rupesh , Mahajan Dhiral R. , Malik Atiullah 
Published: February 2022

Background: India is becoming the “Diabetes Capital of the World”. Younger and younger individuals are being diagnosed with Diabetes. This study was planned to diagnose prediabetes in younger individuals having positive family history with aim of encouraging to develop lifestyle modifications to delay progression to Diabetes.
Aims: To study prediabetes in first degree relatives (FDR) of diabetic patients in the group of 30-45 years by glucose tolerance test (GTT), body mass index (BMI) and waist hip ratio (WHR).
Study Design: Cross sectional observational study.
Place and Duration of Study: Study was conducted at Department of general medicine, Dr D Y Patil Medical College, Pune 18 from July 2019-september 2021.
Methodology: This study conducted in a semi-urban Teaching Hospital in Maharashtra, India. 100 asymptomatic first-degree relatives (31 women, 69 men) age group 30-45 years, of diabetic patients were selected for study after informed consent. The study participants were clinically examined and subjected to OGTT (oral glucose tolerance test) and BMI, WHR were calculated. Data analysis was done using SPSS (Statistical Package for Social Sciences) Software version 20.
Results: In our study, out of 100 participants 61% study subjects were overweight having a BMI of 25-29.90 and 13% were obese. 65% subjects had raised Waist to hip ratio. 36 subjects had raised fasting Blood sugar level (BSL) and 40% had raised 2hr BSL on OGTT and incidence of diabetes and prediabetes were 14% and 26% respectively.
Conclusion: Significant correlation of Prediabetes was seen with abnormal OGTT, Raised Fasting Blood glucose, raised BMI. We found higher incidence of Prediabetes in those with Maternal Diabetes.
Study on Effectiveness of Blastocyst Transfer over Cleavage Stage Embryo Transfer in Patients with Failed Conception
Authors: Chokhandre Rajvee R. , More Akash , Salve Mehul , Shrivastava Deepti 
Published: February 2022

Background: IVF has been proved a blessing for many couples. Embryo selection and transfer are key steps in ART. In-vitro fertilization includes embryo transfer either at cleavage stage (day2/ day3) or at blastocyst stage (day5). Implantation rate can be improved by transferring blastocyst stage embryo. Implantation rate may decrease after repeated unsuccessful implantation. This study aims to assess the effectiveness of Blastocyst Transfer in patients with history of failed Cleavage Stage Embryo Transfer.
Methodology: This will be an observational study conducted at Wardha Test Tube Baby Centre, AVBRH. 40 infertile women with history of previous IVF failure will be included in the study. Embryo Transfer will be done at blastocyst stage and βhcg level will be measured on 14th day of embryo transfer.
Expected Results: We expect that blastocyst stage embryo transfer may give more positive result compare cleavage transfer. We predict that transferring embryo at blastocyst stage may increase implantation and pregnancy rate.
Conclusion: Blastocyst stage embryo transfer is effective compared to Cleavage Stage Embryo Transfer.
A Demographic Profile of ACS Associated with Thyroid Dysfunction in North Indian Population
Authors: Arambam Priyadarshini , Alok Anshu , Taneja Neha , Ranjan Priya , Janardhanan Rajiv , Kaul Upendra 
Published: February 2022

Background: Thyroid disorders have an important bearing on the cardiovascular (CV) system leading to hypertension, dyslipidemia, heart rhythm disorders, obesity etc. Data regarding the influence of subclinical hypothyroidism and CV disease and outcomes have been conflicting. Since subclinical hypothyroidism is seen often in clinical syndromes of coronary artery disease, we undertook this study to evaluate the overall prevalence and demography of patients admitted with the diagnosis of ACS in a North Indian population.
Methods: We studied consecutive 171 hospitalized patients between March 2018 to February 2020 with a diagnosis of acute coronary syndrome (ACS) to determine the features of thyroid dysfunction both clinical and sub-clinical and the associated biochemical parameters. All patients underwent complete medical history of cardiac risk factors for developing CAD. Thyroid function Tests - free T3, free T4 and TSH were collected from all the patients within 24 hours of admission to CCU.
Results: Forty (23%) of these patients had thyroid dysfunction. Subclinical hypothyroidism was the commonest abnormality seen in 26 (23%), followed by overt hypothyroidism 12 (9%). Hyperthyroidism was uncommon (1.5%). Euthyroid sick syndrome was seen in 4% and these patients were excluded.
There was a predilection for the elderly population (females 52%). STEMI (52%) followed by NSTEMI (25%) was the commonest diagnosis at presentation. A significant correlation was seen with serum lipid levels (decreased HDL C, Increased total cholesterol, triglycerides and VLDL C) and hypothyroidism. However, there was no correlation ship with LDL C.
Reduced e glomerular filtration rate (e GFR) which was seen in 50% of patients had a linear relationship with hypothyroidism. Patients with hypothyroidism had no differences in the prevalence of concomitant diabetes and hypertension. The left ventricular ejection fraction (LVEF) in the group of patients had a trend to be lower.
Conclusions: Hypothyroidism seems to be an important risk factor in patients with ACS, especially STEMI. The impairment of renal function was also prominent in these patients. These patients also suffered from impaired renal function.
Antidiabetic and Antiinflammatory Potentials of Sida Acuta Leaf Ethanolic Extract
Authors: Shankar Preethi , Gayathri R. , Selvaraj J. , Priya V. Vishnu 
Published: February 2022

Introduction: Sida acuta is known as common wireweed, and has a pantropical distribution. Antioxidants fight against free radicals and prevent a variety of diseases. Anti Inflammatory reaction is the ability of a substance to reduce swelling or inflammation. Antidiabetic substances are defined as agents which help in maintaining the level of glucose in the blood.
Aim: Present study was aimed at assessing the in vitro antidiabetic and antiinflammatory potentials of Sida acuta leaf ethanolic extract.
Methods: Sida acuta was purchased and its ethanolic extract was prepared. Protein denaturation inhibition, DPPH radical scavenging, alpha amylase and alpha glucosidase inhibitory assays were carried out in order to check in vitro antiinflammatory, antioxidant and antidiabetic activity spectrophotometrically.. The data were analysed using one-way analysis of variance (ONE-WAY ANOVA) to see the statistical significant among the different concentrations of extract. P<0.05 levels were considered as statistical significance.
Results: The extract of Sida acuta was compared with aspirin and an antiinflammatory reaction was analysed. Statistically significant at the levels of p < 0.05.The extract proved to contain antiinflammatory and antioxidant reactions. Alpha amylase and alpha glucosidase activity was analysed by comparing the extract with metformin.
Conclusion: Sida acuta can be used for the management and treatment of various diseases and disorders. It can be used for the treatment of diabetes and cancer.
Comparative Assessment of P. gingivalis Level in Periodontit is Patients with and without Diabetes Mellitus- A PCR based Study
Authors: Shruthi M. , Jeevitha M. , Jayakumar N. D. , Jayaraman Selvaraj 
Published: February 2022

Introduction: Periodontal diseases if left untreated can lead to tooth loss with the main cause being bacterial plaque. Among the subgingival plaque bacterial species, Porphyromonasgingivalis has been implicated as a major etiological agent causing tooth loss. Diabetic patients are at high risk for periodontal disease. Our aim was to compare the involvement of P. gingivalis in diabetes mellitus (DM) patients associated with periodontitis and to compare them with periodontitis patients having no other systemic pathologies.
Materials and Methods: Subgingival plaque samples from a total of 8 patients were collected. DNA was isolated from the collected samples and was quantified using RT-PCR for standardizing the polymerase chain reaction. Paired t test was performed using the statistical software Graphpad prism (Version 7.0).
Results: There was a statistically significant level of P. gingivalis seen in periodontitis patients having DM (p=0.0053), whereas the least score was seen in periodontitis patients without DM.
Conclusion: Poor glycemic control, as indicated by HbA1c≥7%, is associated with increased levels and frequencies of periodontal pathogens in the subgingival biofilm of subjects with DM.
Knowledge, Attitude & Practice of Ultrasonic Bone Surgery (Piezo electric) among Dentists in the State Tamilnadu- KAP Study
Authors: Cynthia R. A. Jenifer , Rathinasamy Kadhiresan , Ulaganathan Arunmozhi , Ramamurthy Shanmuga Priya , Kumar G. Kishore , Kumar J. Arun 
Published: February 2022

Background:
Objectives: To assess the knowledge, attitude, practice of Ultrasonic bone surgery (piezo electric) among dentist in the state of Tamilnadu.
Methods: A set of 29 questions was sent to dentists in and around Tamilnadu. The questionnaire was circulated digitally (Google forms & emails) and responses were recorded. 125 dentists participated in the study, among them 21 dentists were excluded since they did not have any awareness about piezo surgery or the equipment used.
Statistical Analysis: The basic data was expressed used using frequency with percentages and by diagrams. For expressing quantitative variable, mean and standard deviation were used. Kruskal wallis test was used to compare whether knowledge score differed by characteristics of the selected variables and Dunn’s post hoc test was applied to find out which of the characteristics were statistically significant. All the statistical analysis were done using XLSTAT 2014 software
Results: 63% of the dentists had adequate knowledge regarding piezo surgery and 53% of the dentists were currently using piezotome in their dental practice and 47% of dentists use it for harvesting bone grafts and 86% have complimented that it was less traumatic to the hard tissues. 81% felt that patient compliance was better compared to traditional methods like osteotome and chisel. Majority of the dentists showed a positive attitude towards piezosurgery and they extended their willingness to update their knowledge furthermore and emphasized that the concept of piezosurgery, its usage and its advantages should be given adequate importance in future dental education.
Conclusion: This study demonstrated that knowledge and attitude towards piezosurgery was good among the dental professionals, but the actual practice of it is still deficient. This could be probably because of the lack of training in the dental schools, which could be overcome by including piezo surgery in dental curriculum and conducting workshops for improvising the skill of the dentists.
Estimation of Serum Sodium, Potassium and Calcium Levels as Prognostic Markers in Cirrhosis of Liver: A Study Protocol
Authors: Pawar Twinkle , Sarode Rajesh , Kirnake Vijendra , Kumar Sunil , Acharya Sourya , Bawankule Shilpa , Wanjari Anil , Agrawal Sachin 
Published: February 2022

Background: Cirrhosis of the liver is final stage of chronic liver disease [1], which can lead to complications associated with portal hypertension and liver failure. In a much remunerated state, the cirrhotic patient maintains close association to traditional solution and acid–base standing, however this delicate balance may be discontinuous by malady progression, infection, dietary indiscretion/deprivation, or medicine intervention. Many mineral metabolism disorders are represented in relation with hepatic diseases. This study aims to estimate the levels of Sodium, Potassium and Calcium in Cirrhosis of Liver and correlate them with severity of cirrhosis and in-hospital morbidity and mortality.
Materials and Methods: This cross-sectional study is planned to be carried out in Medicine department, AVBRH, Wardha. Total 50 patients with liver diseases will be enrolled. The lab. investigations will include different parameters of liver function tests along with assessment of sodium, potassium and calcium level. Child-Pugh, end-stage liver disease scores model will be determined using required formulas. All such patients’ in-hospital death records will be collected. Data will be collected and analyzed. The mean and standard deviations of the measurements per cluster will be used for applied analysis (SPSS twenty-two.00 for windows; SPSS INC, Chicago, USA). For every assessment purpose, data will be statistically analyzed using factorial ANOVA. Distinction between 2 groups determined using student t-test similarly as chi sq. test (p <.05).
Expected Results: We expect significant correlation between the level of Na, K and Calcium with in-hospital morbidity and mortality in patients of cirrhosis.
Conclusion: Serum levels of calcium, potassium and sodium should be integrated into model for predicting in-hospital mortality in patients of cirrhosis. Considering that prognostic accuracy of elements may well be comparatively modest, any studies ought to confirm clinical quality of liquid body substance sodium, potassium, and Ca concentrations.
A Study Protocol for Estimating the Association of De Ritis ratio (AST/ALT) with Outcomes in Patients of Acute Ischemic Stroke
Authors: Nimkar Shubham , Varma Anuj , Acharya Sourya , Kumar Sunil , Wanjari A. K. , Bawankule Shilpa 
Published: February 2022

Background: One of the clinical endpoints of atherosclerosis is stroke, the most prominent clinical manifestation of cerebrovascular disease. It is a cerebral blood vessel disease that nourishes the brain. A global health concern is stroke. It is the second most prevalent cause of death worldwide and the fourth leading cause of disability. The underlying pathophysiology in most ischemic strokes is atherosclerosis. Few studies have shown that high AST/ALT ratio was independently corelated with the increased danger of complication and death in cerebrovascular event patients. This research aims to assess the correlation of De Ritis ratio in cases of acute ischaemic stroke at admission and their prognosis at 3 months.
Methodology: This will be a observational cross sectional study. About 65 patients with signs suggestive of acute ischemic will be examined. A comprehensive laboratory examination will be carried out. For confirmation of the diagnosis, all patients will undergo CT SCAN or MRI assessment. The primary results of stroke severity on admission will be obtained according to the NIHSS scale. The ranking for NIHSS would be dichotomized to less than 5 and more than 5. For all cases diagnosed with acute ischemic stroke, AST/ALT RATIO will be computed. Data will be analysed with relevant statistical tests.
Results Expected: We expect a significant correlation between serum de-Ritis ratio and prognosis of acute ischaemic stroke.
Measurement of Salivary Lipid Peroxidation in Periodontitis Patients with or Without Diabetes Mellitus
Authors: Raj V. P. R. B. Ranjith , Jeevitha M. , Jayakumar N. D. , Jayaraman Selvaraj 
Published: February 2022

Aim: The aim of the present study is to assess the association of lipid peroxidation in the saliva of healthy and periodontitis patients with or without diabetes mellitus.
Study Design: Cross-sectional study.
Materials and Methods: The study was conducted in the subjects who visited the University dental hospital as outpatients from October 2020 to January 2021.The subjects were categorized into 3 groups: periodontally healthy (Group a), Periodontitis with diabetes mellitus (Group b) and Periodontitis only (Group c)
Results: Lipid peroxidation levels were found to be significantly higher (p<0.021 which is statistically significant) in patients with periodontitis and diabetes mellitus (108 + 7.1) when compared to patients with periodontitis only (77 + 3.5) and healthy group (66+5.6).
Conclusion: The study concluded that lipid peroxidation levels are elevated in patients with periodontitis and diabetes mellitus compared to periodontitis only and also when compared to periodontal health which indicate that lipid peroxidation levels could serve as a biomarker for periodontitis in diabetic patients.
Impact of Hayes Martin Maneuver and Anterograde Dissection on Identification and Preservation of Marginal Mandibular Nerve during Neck Dissection in Patients with Oral Squamous Cell Carcinoma
Authors: Shinde Sumeet , Bhola Nitin , Borle Rajiv 
Published: February 2022

Background: Hayes Martin maneuver (HMM) and Anterograde dissection technique (ADT) were originally described in 1951 as a means of preserving the marginal mandibular nerve (MMN) during level 1B clearance in a neck dissection procedure address the cervical metastasis in patients with oral squamous cell carcinomas.
Objectives: To compare and evaluate the efficacy of HMM and ADT in preservation of MMN using Electromyography of muscles supplied by the nerve ie Mentalis, Depressor labii inferioris and depressor anguli oris, to evaluate muscle function.
Methodology: 20 patients undergoing neck dissection over a period of 6 months grouped were into two groups (10 patients for Hayes Martin manoeuvre and 10 patients for anterograde dissection technique) calculated by purposive sampling method. Postoperative Electromyography and assessment of nerve function using House and Brackmann grading was done on day 5,15 and 30.
Expected Results: HMM proves to be a less time consuming technique than Anterograde dissection by a significant margin considering perifacial node clearance and level 1B clearance. Anterograde dissection technique proved to be more effective than Hayes Martin Maneuver for preservation of MMN as average neuromuscular electrical activity in anterograde dissection cases was higher than the average of HMM cases. Although, no significant statistical difference was found when the neural function was compared on a house and brackmann grading scale
Conclusion: Anterograde dissection technique is technique sensitive, relatively time consuming and requires a higher surgical operator skill. However, provides statistically proven better results in terms of neural electric activity and post-operative functional neural deficit in the operated subjects.