bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-Year Outcomes in Anticoagulated Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention: Insights From the Greek Antiplatelet Atrial Fibrillation Registry
Authors: Alexopoulos Dimitrios , Dragona Vassiliki-Maria , Varlamos Charalampos , Ktenas Dionysios , Lianos Ioannis , Patsilinakos Sotirios , Sionis Dimitrios , Zarifis Ioannis , Bampali Theodora , Poulimenos Leonidas , Skalidis Emmanouil , Pissimisis Evangelos , Trikas Athanasios , Tsiafoutis Ioannis , Kafkas Nickolaos , Olympios Christoforos , Tziakas Dimitrios , Ziakas Antonios , Voudris Vassilis , Kanakakis Ioannis , Tsioufis Costas , Davlouros Periklis , Benetou Despoina-Rafailia 
Published: November 2022

Abstract:
GReek-AntiPlatElet Atrial Fibrillation registry is a multicenter, observational, noninterventional study of atrial fibrillation patients undergoing percutaneous coronary intervention. Primary endpoint included clinically significant bleeding rate at 12 months between different antithrombotic regimens prescribed at discharge; secondary endpoints included major adverse cardiovascular events and net adverse clinical events. A total of 647 patients were analyzed. Most (92.9%) were discharged on novel oral anticoagulants with only 7.1% receiving the vitamin K antagonist. A little over half of patients (50.4%) received triple antithrombotic therapy (TAT)—mostly (62.9%) for ≤1 month—whereas the rest (49.6%) received dual antithrombotic therapy (DAT). Clinically significant bleeding risk was similar between TAT and DAT [Hazard ratio (HR) = 1.08; 95% confidence interval (CI), 0.66–1.78], although among TAT-receiving patients, the risk was lower in those receiving TAT for ≤1 month (HR = 0.50; 95% CI, 0.25–0.99). Anticoagulant choice (novel oral anticoagulant vs. vitamin K antagonist) did not significantly affect bleeding rates (P = 0.258). Age, heart failure, leukemia/myelodysplasia, and acute coronary syndrome were associated with increased bleeding rates. Risk of major adverse cardiovascular events and net adverse clinical events was similar between ΤAT and DAT (HR = 1.73; 95% CI, 0.95–3.18, P = 0.075 and HR = 1.39; 95% CI, 0.93–2.08, P = 0.106, respectively). In conclusion, clinically significant bleeding and ischemic rates were similar between DAT and TAT, although TAT >1 month was associated with higher bleeding risk.
Allogeneic stem cell transplant in relapsed/ refractory Hodgkin lymphoma: A 21 years’ experience
Authors: Couto Maria Eduarda , Vaz Carlos Pinho , Branca Rosa , Leite Luís , Brás Gil , Roncon Susana , Campos Antonio 
Published: November 2022

Abstract

Background: Allogenic stem cell transplant (alloSCT) has been used for several decades as a salvage strategy for relapsed/ refractory Hodgkin lymphoma (R/R HL), being a durable disease control method for some patients.

Methods: A unicenter retrospective analysis was performed about alloSCT in R/R HL along 21 years. A survival analysis was made in search for prognostic factors with impact in overall survival (OS)/progression free survival (PFS).

Results: Thirty-five patients were reviewed: median age 30years [17-46], 57.1% males, 82.9% had an esclero-nodular HL, 54.3% were in stage II of disease, and 42.9% achieved a complete response before the alloSCT. The donor type was matched-related in 54.3% and the stem cell source was peripheral blood in 97.1% of the grafts. All patients did a reduced intensity conditioning regimen. The overall response rate was 85.7% (complete in 68.6%, partial in 17.1%). Acute graft versus host disease grade II-IVwas seen in 45.7%. Transplant related mortality at day 360 was 17.9%. The median OS was 61 months (95% confidente interval: 33.6-88.3). The median PFS was 1Omonths (95% confidente interval: 3.1-16.9). Patients with >3Oyears at the alloSCT time and a previous autologous SCT showed better OS/PFS in the univariate analysis; having a matched donor and absence of infections along the alloSCT also improved PFS.

Conclusions: AlloSCT is a feasible procedure in patients with R/R HL, being able to stabilize the disease in a large number of patients. However, it has a relevant toxicity in patients highly pre-treated.
Dual beta-lactam treatment: Pros and cons
Authors: Guerra Diogo , Vidal Pauline , Paccoud Olivier , Maillard Alexis , Cachera Laurene , Junot Helga , Gauzit Rémy , Zahar Jean R. , Abreu Miguel A. , Bleibtreu Alexandre 
Published: November 2022

Abstract
The battle against microscopic pathogens has always baffled the scientific community. Nowadays, multidrug-resistant microorganisms lead to high in-hospital mortality, increased hospital stays, and high health-related costs. Treating infections due to these high-resistance pathogens with a low number of antibiotic molecules creates the need for new strategies. Although some already think of a “postantibiotic era” with bacteriophages as the main futuristic weapon in antibacterial armament, others rethink the usage of the already existent drugs. Dual beta-lactam therapy has been used for quite some time as an empirical therapy for some severe infections such as endocarditis or meningitis. However, studies regarding the use of a beta-lactam combination stopped being made a long time ago, and it seems the scientific community has no interest in evaluating this as a treatment option. Could this strategy be applied to treat infections due to multidrug-resistant bacteria? Could this be the answer while waiting for the “postantibiotic era”? What kind of pathogens could we fight using dual beta-lactams? What are the downsides of this strategy? These are some of the questions the authors try to answer in this review. In addition, we try to convince our peers to turn once more into researching beta-lactam combinations and exploring its potential benefits.
Clinicopathological features of head and neck cutaneous basal cell carcinoma observed at the Centro Hospitalar de Trás-os-Montes e Alto Douro ENT Department
Authors: Castanheira António , Boaventura Paula , Vieira Fortunato , Soares Paula , Mota Alberto , Lopes José Manuel 
Published: November 2022

Abstract

Background:
Cutaneous basal cell carcinoma (cBCC) incidence has been increasing, but there are no available data on its epidemiological, clinical, and pathological patterns in Northeast Portugal. cBCC is mainly located in the head and neck, where the ear, neck, and throat (ENT) surgeon may have a major role. We aimed to verify the clinicopathological characteristics of basal cell carcinomas diagnosed in an ENT department.

Methods:
We performed a retrospective clinicopathological evaluation of the head and neck cBCC cases followed up at the Centro Hospitalar de Trás-os-Montes e Alto Douro (CHTMAD) ENT Department between January 2007 and April 2021.

Results:
One hundred seventy-four patients with 293 cBCCs were included in this retrospective study. We observed that about one-third of the patients had multiple cBCCs (30.5%) and an infiltrative-type growth pattern (39.3%), both features considered as patterns that are more aggressive. Infiltrative-type growth pattern cBCCs were significantly larger when compared with the indolent-type growth pattern (16.2 mm vs 10.8 mm).

Conclusions:
To the best of our knowledge, this is the first study about cBCC in a patient population followed up at an ENT hospital department. This study has shown that these patients had cBCCs with more aggressive features, making these tumors an important issue for the ENT surgeon.
Student Performance Metrics and the Physician Assistant National Certifying Exam®: A 3-Year Multi-Institutional Study
Authors: Collett DeShana , Wright Karen A. , Woltenberg Leslie , Nagasawa Pamela R. , LeLacheur Susan 
Published: November 2022

Introduction
Given the 2019 Physician Assistant National Certifying Exam (PANCE) blueprint update from the National Commission on the Certification of Physician Assistants, it is imperative that programs conduct analyses of student performance metrics and PANCE scores. The purpose of this multi-institutional study was to examine the relationship between PANCE scores and student performance metrics/attributes from PA program graduates from 2017-2019.

Methods
A multiple linear regression was calculated to predict PANCE score indicators based on student attributes and performance metrics from 3 PA programs. Metrics included: PAEA End of Rotation exams, PACKRAT scores, academic performance in clinical medicine didactic courses, cumulative grade point average, and select demographic and admissions attributes (age, sex, and first generation to attend college). Descriptive statistics were employed to provide contextual information and an overview of the included data points.

Results
A significant regression equation was found with r-square of 0.709. Clinical Medicine II didactic course grades, PACKRAT I & II scores, and PAEA End of Rotation Exam scores in Family Medicine and Internal Medicine were all significant predictors of PANCE score.

Discussion
In consideration of the Accreditation Review Commission on Education for the Physician Assistant (ARC-PA) Standards and expectations for ongoing self-assessment, including PANCE analysis, this research was timely and necessary. To date, there is very limited research regarding student performance metrics given the PANCE blueprint update in 2019, and these data are critical to aid programs in ongoing development and best preparation for learners.
Assessing the Utility of Mental Health First Aid Training for Physician Assistant Students
Authors: Forbes Jennifer , Noller Diana T. , Henriquez Madeleine , Scantamburlo Sarah , Ward Ian , Lee Hwal 
Published: November 2022

Introduction
Physician assistant (PA) students are at increased risk for anxiety and depression compared with the general population. The demands of studying medicine can contribute to a decline in mental health, which may impede a student’s ability to progress in his or her PA program. Mental Health First Aid (MHFA) is one strategy that can be used to increase mental health literacy, promote help-seeking behavior, reduce stigma, and improve confidence in providing help to individuals showing signs of a mental health disorder. The aim of this outcomes assessment was to assess PA students’ satisfaction with the MHFA course and their posttraining confidence in using the skills learned.

Methods
Participants were PA students (N = 435) across 9 PA programs in their didactic year of training who had completed an MHFA course through the PA Foundation’s Mental Health Outreach Fellowship. MHFA postcourse evaluations, completed by the PA students, were analyzed to determine PA students’ satisfaction with the course and their posttraining confidence in using the skills learned to help both themselves as well as the general population.

Results
The mean of the MHFA course evaluation items corresponding to satisfaction with the course was 4.82 (maximum score of 5), and the mean of the items corresponding to posttraining confidence in using the skills learned was 4.74 (maximum score of 5). When asked, “Would you recommend this course to others?” 99.3% of the PA students trained in MHFA answered “yes,” indicating a high level of satisfaction with the training they had received.

DIscussion
PA students who received MHFA training from the PA Foundation’s Mental Health Outreach fellows showed high levels of satisfaction with the MHFA course and posttraining confidence in using the skills learned.
Exploring Hybrid Leadership
Authors: Ameel Maria , Myllynen Mika , Kallakorpi Susanna 
Published: November 2022

OBJECTIVE
The aim of this study was to describe leaders' experiences of remote leadership during the 1st year of the COVID-19 pandemic.

BACKGROUND
The COVID-19 pandemic accelerated remote work. However, there is little research on the experience of remote leadership in the healthcare setting.

METHODS
Data were collected using focus group interviews and analyzed by thematic analysis.

RESULTS
A total of 8 leaders from a psychiatric care setting participated. The following themes were identified: increased work efficiency, work well-being, lack of organizational support, the need to be present, and the desire for a hybrid leadership model for the future.

CONCLUSIONS
Remote leadership includes both benefits and challenges for healthcare leaders and organizations. Leaders in this study emphasized the need to be present for the clinical personnel and proposed a hybrid leadership model. To succeed in combining remote and face-to-face work and leadership in a new model, organizations need to provide clear guidelines and training for remote work and leadership.
Chloroquine Supplementation for the Treatment of Glioblastoma: A Meta-analysis of Randomized Controlled Studies
Authors: Deng Qiang , Tao Sihong , Huang Hui , Lv Qikun , Wang Wei 
Published: November 2022

Introduction
Chloroquine supplementation may show some potential in improving the efficacy for glioblastoma, and this meta-analysis aimed to identify the efficacy of chloroquine supplementation for patients with glioblastoma.

Methods
Several databases including PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases have been systematically searched through August 2022, and we included randomized controlled trials assessing the efficacy of chloroquine supplementation for glioblastoma. This meta-analysis was performed using the random-effect model or fixed-effect model based on the heterogeneity.

Results
Four randomized controlled trials were finally included in this meta-analysis. In comparison with control group for glioblastoma, chloroquine supplementation was associated with substantially decreased mortality (odd ratio [OR], 0.17; 95% confidence interval [CI], 0.06–0.53; P = 0.002), improved survival time (mean difference, 15.63; 95% CI, 2.27–28.99; P = 0.02), and remission (OR, 15.63; 95% CI, 2.27–28.99; P = 0.02), but unraveled no obvious impact on the incidence of adverse events (OR, 3.27; 95% CI, 0.29–36.44; P = 0.34) or seizure (OR, 2.57; 95% CI, 0.05–127.68; P = 0.64).

Conclusions
Chloroquine supplementation may be effective to improve the treatment efficacy for glioblastoma.
Hemophagocytic lymphohistiocytosis due to Burkholderia pseudomallei in a primigravida.
Authors: al Waseem Shaikh Mohammed Haroon , Antony Tessa , Suresh Suchitra , Gopalan Sowmya 
Published: November 2022

Introduction

Introduction: Melioidosis is an infection caused by, Burkholderia pseudomallei (B.pseudomallei), a facultative intracellular gram-negative, saprophytic bacilli, commonly found in soil or contaminated water.The organism is aptly called the “great mimicker” as it produces a wide variety of clinical manifestations.
Case report: A 24-year-old primigravida was referred to the medicine outpatient department with complaints of fever and myalgia of 45 days duration. Laboratory investigations revealed anaemia, elevated serum ferritin and hepatosplenomegaly. Bone marrow study showed the presence of hemophagocytes and a diagnosis of hemophagocytic lymphohistiocytosis(HLH) was made. Blood and bone marrow culture sent to the microbiology laboratory grew non fermenting gram negative bacilli which was misidentified as Burkholderia cepacia by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (VITEK 2 system bioMérieux ). It was further identified as B.pseudomallei by 16S ribosomal RNA sequencing. Patient was treated with steroids and ceftazidime. She had to undergo medical termination of pregnancy as there was severe intrauterine growth restriction(IUGR) of the foetus. She responded well to the treatment and was discharged with maintenance therapy of sulfamethoxazole and trimethoprim.
Conclusion: It is important to find out if the suspected pathogen is listed in the database of the automated identification system. Prognosis of melioidosis is excellent if early diagnosis and appropriate antibiotic treatment is provided.
Improved high-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors
Authors: Nagle Alliot , Gerrelts Josh P. , Krause Bryan M. , Boes Aaron D. , Bruss Joel E. , Nourski Kirill V. , Banks Matthew I. , Van Veen Barry 
Published: November 2022

AbstractMultivariate autoregressive (MVAR) model estimation enables assessment of causal interactions in brain networks. However, accurately estimating MVAR models for high-dimensional electrophysiological recordings is challenging due to the extensive data requirements. Hence, the applicability of MVAR models for study of brain behavior over hundreds of recording sites has been very limited. Prior work has focused on different strategies for selecting a subset of important MVAR coefficients in the model and is motivated by the potential of MVAR models and the data requirements of conventional least-squares estimation algorithms. Here we propose incorporating prior information, such as fMRI, into MVAR model estimation using a weighted group LASSO regularization strategy. The proposed approach is shown to reduce data requirements by a factor of two relative to the recently proposed group LASSO method of Endemann et al. (2022) while resulting in models that are both more parsimonious and have higher fidelity to the ground truth. The effectiveness of the method is demonstrated using simulation studies of physiologically realistic MVAR models derived from iEEG data. The robustness of the approach to deviations between the conditions under which the prior information and iEEG data is obtained is illustrated using models from data collected in different sleep stages. This approach will allow accurate effective connectivity analyses over short time scales, facilitating investigations of causal interactions in the brain underlying perception and cognition during rapid transitions in behavioral state.
Interactive Effects of Venlafaxine and Thermal Stress on Zebrafish (Danio rerio) Inflammatory and Heat Shock Responses
Authors: Weber A.V. , Firth B.F. , Cadonic I. G. , Craig P.M. 
Published: November 2022

AbstractVenlafaxine (VFX), a commonly prescribed antidepressant often detected in wastewater effluent, and acute temperature elevations from climate change and increased urbanization, are two environmental stressors currently placing freshwater ecosystems at risk. This study focused on understanding if exposure to VFX impacts the agitation temperature (Tag) and critical thermal maximum (CTmax) of zebrafish (Danio rerio). Additionally, we examined the interactive effects of VFX and acute thermal stress on zebrafish heat shock and inflammatory immune responses. A 96 hour 1.0 μg/L VFX exposure experiment was conducted, followed by assessment of thermal tolerance via CTmaxchallenge. Heat shock proteins and pro-inflammatory immune cytokines were quantified through gene expression analysis by quantitative PCR (qPCR) onhsp 70, hsp 90, hsp 47, il-8, tnfα, andil-1βwithin gill and liver tissue. No significant changes in agitation temperature between control and exposed fish were observed, nor were there any differences in CTmaxbased on treatment. Unsurprisingly,hsp 47, 70, and 90were all upregulated in groups exposed solely to CTmax, while onlyhsp 47within gill tissue showed signs of interactive effects, which was significantly decreased in fish exposed to both VFX and CTmax. No induction of an inflammatory response occurred. This study demonstrated that environmentally relevant concentrations of VFX have no impact on thermal tolerance performance in zebrafish. However, VFX is capable of causing diminished function of protective heat shock mechanisms, which could be detrimental to freshwater fish populations and aquatic ecosystems as temperature spikes become more frequent from climate change and urbanization near watersheds.Summary StatementThis study predicts the effects that climate change and anthropogenic pollutants may have on fish ability to tolerate elevated temperatures, and examines the physiologic challenges these stressors may introduce.
Human Monkeypox Virus outbreak among Men who have Sex with Men in Amsterdam and Rotterdam, the Netherlands: no evidence for undetected transmission prior to May 2022 in a retrospective study
Authors: de Vries Henry J. , Götz Hannelore M. , Bruisten Sylvia , van der Eijk Annemiek A. , Prins Maria , Oude Munnink Bas B. , Welkers Matthijs R.A. , Jonges Marcel , Molenkamp Richard , Westerhuis Brenda M. , Schuele Leonard , Stam Arjen , Boter Marjan , Hoornenborg Elske , Mulders Daphne , van den Lubben Mariken , Koopmans Marion 
Published: November 2022

AbstractSince May 2022 over 20.000 human monkeypox virus (hMPXV) cases have been reported from 29 EU/EEA countries, predominantly among men who have sex with men. With over 1200 cases, and a crude notification rate of 70.7 per million population, the Netherlands was in the top 5 European countries most affected. The first national case was reported from May 10th, yet potential prior transmission remains unknown. Insight into prolonged undetected transmission can help to understand the current outbreak dynamics and aid future public health interventions. We therefor performed a retrospective study to elucidate whether undetected transmission of hMPXV occurred prior to the first reported cases in Amsterdam and Rotterdam. In 401 anorectal- and ulcer samples from visitors of the Centers for Sexual Health of Amsterdam and Rotterdam dating back to February 14th, we identified 2 new cases, the earliest from the first week of May (week 18), 2022. This coincides with the first cases reported in the United Kingdom, Spain and Portugal. We found no evidence of widespread hMPXV transmission in Dutch sexual networks of MSM prior to May 2022. Likely, the hMPXV outbreak expanded across Europe within a short period in the spring of 2022 in an international highly intertwined network of sexually active MSM.Ethical statementThe Amsterdam University Medical Centre Ethical committee approved the study and deemed a full review not necessary according to the Medical Research Involving Human Subjects Act (reference letter: W22_257 # 22.313, dd July 14, 2022). Samples included from Rotterdam were required to be collected more than 3 weeks prior to the analysis (i.e. the duration of quarantine in case of a positive result) as they were deemed to be of no consequence for the index or his/her contacts. All samples and collected data were fully de-identified before sample analysis assuring anonymity.