bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Value of Previous Coronary Stent Implantation in Patients
Undergoing Myocardial Revascularization Surgery
Authors: Villaescusa-Catalan Jose Manuel , Rodríguez-Capitán Jorge , Sanz-Sánchez Cristina Isabel , Sánchez-Espín Gemma , Guerrero-Orriach José Luis , Morón Francisco Javier Pavón , Fernández-Romero Lourdes , Melero-Tejedor José María , Such-Martínez Miguel , Porras-Martín Carlos , Jiménez-Navarro Manuel 
Published: September 2022

Background:
Currently, studies are underway to determine whether coronary stent implantation
with percutaneous transluminal coronary angioplasty before a coronary artery bypass graft (CABG)
influences the prognosis of surgery. This study aimed to assess the need for future revascularisation or
all-cause mortality as a composite endpoint after CABG surgery among patients with previous stent
implantation.

Methods:
A retrospective, non-randomised study was performed on 721 patients who underwent
CABGin our centre between 2012 and 2017. This single-centre study compared two groups: 1) the previous
stent group, patients with previous stent implantation (n=144), and 2) the non-previous stent
group, patients without previous stent implantation (n=577).

Results:
After a median follow-up of 36 months, the previous stent group presented a decreased combined
event-free survival at 1, 3 and 5 years compared with the non-previous stent group (67.4, 43.5 and
23.0% vs. 91.0, 80.3 and 63.0%, respectively; p<0.01). There was also higher mortality in the previous
stent group than in the non-previous stent group (96.1, 90.5 and 79.4 vs. 91.9, 75.9 and 51.0, respectively;
p=0.01). The multivariable analysis of demographics, baseline comorbidity and surgical data showed
previous stent implantation as an independent predictor of the composite endpoint (Hazard Ratio=3.00
and 95% confident interval=2.09-4.32; p<0.01).

Conclusions:
Patients with percutaneous coronary intervention before CABG present higher comorbidities
and clinical events during follow-up than those who do not undergo stenting.
A Real-world Pilot Observational Study of Neuropathic Pain Medications in Older Adult Patients in North India
Authors: Chakrabarti Sankha Shubhra , Kaur Upinder , Dwivedi Vandana , Singh Alok , Singh Amit , Pandey Arun Raj , Acharya Kumudini 
Published: September 2022

Aims:This pilot study aimed to make head-to-head comparisons of multiple classes of drugs used in the management of neuropathic pain in North Indian older adult patients presenting to the geriatric clinic of a tertiary medical institutionBackground:Chronic neuropathic pain is a condition affecting nearly one third of older adults. There is paucity of data on head-to-head comparisons of drugs used in neuropathic pain in older adults. Real world studies may be a useful tool to study diverse neuropathic pain medications in this population.Objectives:The study objective was to measure NPRS (numeric pain rating scale), GDS (geriatric depression scale), IADL (instrumental activities of daily living), HMSE (Hindi mental state examination) scores at baseline, and 4- and 12-week follow-ups in all older adults patients receiving neuropathic pain medications.Methods:A prospective observational study was conducted involving older adult patients ≥ 50 years of age with painful peripheral neuropathy of any etiology (n=60; mean age 63±8.4 years). The patients received either gabapentin, pregabalin, duloxetine, amitriptyline, or methyl-cobalamin complex. NPRS, GDS, IADL, and HMSE scores were measured at baseline and post-therapy.Results:All groups except amitriptyline showed statistically significant improvement in NPRS at 4 weeks and 12 weeks compared to baseline. 30% response rate at 4 weeks was maximum for pregabalin (72%) and 50% response rate at 12 weeks was maximum for gabapentin (58%). Numerically maximum improvement in depression was seen with duloxetine. There was no statistically significant difference in the measured parameters between the drug groups across time. Mean daily dose was 172 mg (gabapentin group), 75 mg (pregabalin group) and 20 mg (duloxetine group). The adverse drug reaction rate was 10.5%.Conclusion:All drug groups showed beneficial effects on neuropathic pain at much lower doses than those described in the literature. The effectiveness at these low doses and the lower rates of adverse effects sets the foundation for larger studies in the future in diverse ethnic and aged populations.
Therapeutic uses of Antihistamines in the Management of COVID-19:
A Narrative Review
Authors: Hosseinjani Hesamoddin , Ataei Mahshid , Arasteh Omid , Maghsoudi Armin Salek , Hassani Shokoufeh 
Published: September 2022

Background:
The first case of COVID-19 emerged in China in 2019 and spread rapidly
worldwide. Therefore, all researchers worldwide sought ways to treat and prevent the disease.
Since the production of vaccines and new drugs is time-consuming, a good way is to look
at existing drugs to find new effects.

Objective:
Due to the pathogenic mechanism of COVID-19, most of its symptoms, including
anosmia, ageusia, and cytokine storm, are dependent on the release of histamine and its activities.
Therefore, one category of drugs that may be effective in treating and improving the symptoms
of COVID-19 is antihistamines. This paper reviewed studies that have been done so far on the
effects of antihistamines, specially famotidine, in COVID-19.

Method:
A literature search was performed using scientific databases such as PubMed, Web of
Science, Scopus, and Google Scholar from the beginning up to December 2021. The most relevant
articles considering the potential impacts of antihistamines against COVID-19 were collected.

Results:
In addition to the current medications prescribed for the treatment of SARS-CoV-2, H1
and H2 blockers are promising drugs for repurposing in the COVID-19 remedy. Several studies
on famotidine were performed using virtual screening to determine whether they are effective.
Many studies have shown that famotidine use improved COVID-19 symptoms and reduced the
need for intubation and mortality. However, few studies concluded that famotidine is ineffective.

Conclusion:
Antihistamines, and specifically famotidine, are effective in reducing COVID-19
symptoms. Therefore, they are a good choice for combination therapy with other drugs to treat
COVID-19.
The Emotional Anatomy of the Wuhan Lockdown: Sentiment Analysis Using Weibo Data
Authors: Chen Xi , Yik Michelle 
Published: September 2022

Background
On January 23, 2020, the city of Wuhan, China, was sealed off in response to the COVID-19 pandemic. Studies have found that the lockdown was associated with both positive and negative emotions, although their findings are not conclusive. In these studies, emotional responses to the Wuhan lockdown were identified using lexicons based on limited emotion types.

Objective
This study aims to map Chinese people’s emotional responses to the Wuhan lockdown and compare Wuhan residents’ emotions with those of people elsewhere in China by analyzing social media data from Weibo using a lexicon based on the circumplex model of affect.

Methods
Social media posts on Weibo from 2 weeks before to 2 weeks after the Wuhan lockdown was imposed (January 9, 2020, to February 6, 2020) were collected. Each post was coded using a valence score and an arousal score. To map emotional trajectories during the study period, we used a data set of 359,190 posts. To compare the immediate emotional responses to the lockdown and its longer-term emotional impact on Wuhan residents (n=1236) and non-Hubei residents (n=12,714), we used a second data set of 57,685 posts for multilevel modeling analyses.

Results
Most posts (248,757/359,190, 69.25%) made during the studied lockdown period indicated a pleasant mood with low arousal. A gradual increase in both valence and arousal before the lockdown was observed. The posts after the lockdown was imposed had higher valence and arousal than prelockdown posts. On the day of lockdown, the non-Hubei group had a temporarily boosted valence (γ20=0.118; SE 0.021; P<.001) and arousal (γ30=0.293; SE 0.022; P<.001). Compared with non-Hubei residents, the Wuhan group had smaller increases in valence (γ21=−0.172; SE 0.052; P<.001) and arousal (γ31=−0.262; SE 0.053; P<.001) on the day of lockdown. Weibo users’ emotional valence (γ40=0.000; SE 0.001; P=.71) and arousal (γ40=0.001; SE 0.001; P=.56) remained stable over the 2 weeks after the lockdown was imposed regardless of geographical location (valence: γ41=−0.004, SE 0.003, and P=.16; arousal: γ41=0.003, SE 0.003, and P=.26).

Conclusions
During the early stages of the pandemic, most Weibo posts indicated a pleasant mood with low arousal. The overall increase in the posts’ valence and arousal after the lockdown announcement might indicate collective cohesion and mutual support in web-based communities during a public health crisis. Compared with the temporary increases in valence and arousal of non-Hubei users on the day of lockdown, Wuhan residents’ emotions were less affected by the announcement. Overall, our data suggest that Weibo users were not influenced by the lockdown measures in the 2 weeks after the lockdown announcement. Our findings offer policy makers insights into the usefulness of social connections in maintaining the psychological well-being of people affected by a lockdown.
Experimental Evaluation and Finite Element Simulation to Produce Square Cup by Deep Drawing Process
Authors: Younis Karem Muhsin , Jabber Adil Shbeeb , Abdulrazaq Mustafa Mohammed 
Published: September 2022

Deep drawing process to produce square cup is very complex process due to a lot of process parameters which control on this process, therefore associated with it many of defects such as earing, wrinkling and fracture. Study of the effect of some process parameters to determine the values of these parameters which give the best result, the distributions for the thickness and depths of the cup were used to estimate the effect of the parameters on the cup numerically, in addition to experimental verification just to the conditions which give the best numerical predictions in order to reduce the time, efforts and costs for producing square cup with less defects experimentally is the aim of this study. The numerical analysis is used to study the effect of some parameters such as die profile radius, radial clearance between die and punch, blank diameter on the length and thickness distributions on the cup, dynamic-explicit (ANSYS11) code based on finite element method is utilized to simulate the square deep drawing operation. Experiments were done for comparison and verification the numerical predictions. effective square cup with less defects and acceptable thickness distributions were produced in this study. It is concluded the most thinning appear in the corner cup due to excessive stretching occur in this region and also it is found the cup thickness and height prediction by numerical analysis and in general in harmony with experimental analysis.
Study the Effect of Forming Media on the Hydroforming Process for Copper Tube
Authors: Salman Rusul AbdulKareem , Ameen Hani Aziz , Mashloosh Kadhim Mijbel 
Published: September 2022

To observe the effect of media of the internal pressure on the equivalent stress distribution in the tube, an experimental study is done by constructing a testing rig to apply the hydraulic pressure and three dies are manufactured with different bulging configurations (square, cosine, and conical). In the other part, ANSYS APDL is generated to analyze the bulging process with hydraulic and rubber (natural and industrial) media. It was found that when the media is a rubber, the stress is decreased about 9.068% in case of cosine die and 5.4439% in case of conical die and 2.8544% in case of square die. So, it can be concluded that the internal pressure in the rubber media is much better than in hydraulic media. Also, the force needed for forming the shape using rubber is higher than that of hydraulic and the force needed to form using industrial rubber is higher than of natural rubber. The thickness distribution in the tube wall in case of rubber media is better than that for hydraulic media and for the industrial rubber is better than that for natural rubber for the same dies. In case of hydraulic, the lower forming pressure is needed to bulging process compared with the rubber media since height stress in the tube metal is existed, which causes the failure. For the case of rubber, the forming pressure that was needed to bulge process is higher when compared with the hydraulic media but with less stress in tube metal and the failure in the wall is not existed with rubber media for the same pressure of hydraulic.
Open Research in the Classroom
Authors: Wilson Emma 
Published: September 2022

Open research practices can benefit students, researchers, and the research community by improving the quality, transparency, and accessibility of research findings. Many groups such as the Edinburgh Open Research Initiative (EORI) and the Framework for Open and Reproducible Research Training (FORRT) aim to promote the integration of open research practices into university curriculums.
Senior year high school pupils preparing to study STEM (Science, Technology, Engineering and Maths) of Social Sciences subjects at university will often conduct their first research project as part of an Advanced Higher course, Nuffield Research Placement, or CREST Award. We have recently received funding to develop resources aimed at introducing S4-S6 Scottish High School pupils to open research practices. Already there is keen interest from Scottish Schools Education Research Centre (SSERC), who run Nuffield Research Placements in Scotland, to make these resources available to all pupils completing placements.
We are currently looking for a small group of UoE students (undergraduate or postgraduate) to assist in developing two short animation scripts on open research topics and an interactive activity. Students will be reimbursed for contributing to the project.
Students should be knowledgeable on open research topics (although you don’t have to be an expert!). Science communication experience is not required, although we will encourage all student volunteers to sign up to the STEM Ambassadors programme.
We are not able to use our funding to reimburse staff members, but UoE staff are more than welcome to register their interest in our project and help out with developing or assuring the quality of our resources.
This project is funded by alumni and friends of the University of Edinburgh through the Student Experience Grant scheme.
Research Management in "Many Analysts" Projects
Authors: Coretta Stefano , Casillas Joseph , Roettger Timo 
Published: September 2022

With the recent increase of large scientific collaborations in the form of "Many Analysts" projects, research project management has quickly moved from small/medium-scale coordination to large-scale planning. Project coordinators are faced with unprecedented challenges which make "Many Analysts" projects time consuming and resource demanding. With this poster, we would like to share our experience managing the ongoing Many Speech Analysis project (https://many-speech-analyses.github.io) and offer tips and logistic solutions to minimise the resource overhead required for such type of projects. We will also discuss which steps in the process didn't go as expected and how on hindsight we wished we approached them.

More specifically we will discuss the following aspects:

Overall design of the study in five phases: recruitment, teams' analyses, analyses peer-review, meta-analysis and write-up.
Preparation of a Registered Report and process of getting an In Principle Acceptance prior to the beginning of the first phase (recruitment).
Preparation and management of a project-wide OSF repository using the R package osfr, and integration with GitHub.
Logistics of recruitment and team creation with social media, Eventbrite and Google Sheets.
Development of questionnaires to gather background information on the recruited analysts and to collect reports on the the teams' analyses.
General project management with GitHub projects, issues and GitHub actions.
ÖĞRETİM ELEMANLARININ EĞİTİMDE ÇOKKÜLTÜRLÜLÜK TUTUMLARI
Authors: ERGİN Ayşegül Zeynep , FAZLIOĞLU Yeşim , ERGİN Demirali Yaşar 
Published: September 2022

Çalışmanın amacı Eğitim Fakültesi akademisyenlerinin eğitimde çokkültürlülük hakkındaki tutumlarını saptamaktır. Bu genel amaç çerçevesinde bağımsız değişkenler olarak Eğitim Fakültesi akademisyenlerinin tutumlarının bazı demografik özelliklere göre farklılık gösterip göstermediği incelenmiştir.
Çalışma, 2016-2017 bahar yarıyılında Trakya Üniversitesi Eğitim Fakültesinde kadrolu olarak görev yapmakta olan 94 akademisyen ile yürütülmüştür. Veri toplama aracı olarak, Yazıcı, Başol, Toprak (2009) tarafından hazırlanan “Öğretmenlerin Çokkültürlü Eğitim Tutumları Ölçeği” kullanılmıştır. Ölçek 5'li derecelemeli 20 maddeden oluşmaktadır. Bu araştırmada verilerin istatistiksel çözümlenmesinde t testi, varyans analizi ve farkın kaynağını saptamak amacıyla Post hoc analiz için LSD teknikleri kullanılmıştır.
Eğitim fakültesi öğretim elemanlarının araştırmada sorgulanan tüm bağımsız değişkenlerdeki durumları ne olursa olsun, hepsinin eğitimde çokkültürlülük hakkında yüksek düzeyde olumlu tutuma sahip oldukları görülmektedir. Öğretmenleri yetiştirecek olan öğretmenlerin olumlu tutuma sahip olmaları sevindiricidir.
COVID-19 patients with acute pulmonary embolism have a higher mortality risk: systematic review and meta-analysis based on Italian cohorts
Authors: Zuin Marco , Rigatelli Gianluca , Bilato Claudio , Quadretti Laura , Roncon Loris , Zuliani Giovanni 
Published: September 2022

Background
Acute pulmonary embolism has been recognized as a frequent complication of COVID-19 infection influencing the clinical course and outcomes of these patients.

Objectives
We performed a systematic review and meta-analysis to evaluate the mortality risk in COVID-19 Italian patients complicated by acute pulmonary embolism in the short-term period.

Methods
The study was performed in accordance with the Preferred Report Items for Systematic Reviews and Meta-analyses guidelines. PubMed-MEDLINE and Scopus databases were systematically searched for articles, published in the English language and enrolling Italian cohorts with confirmed COVID-19 infection from inception through 20 October 2021. Mortality risk data were pooled using the Mantel–Haenszel random effects models with odds ratio as the effect measure with 95% confidence interval. Heterogeneity among studies was assessed using Higgins and Thomson I
2 statistic.

Results
Eight investigations enrolling 1.681 patients (mean age 64.9 years, 1125 males) met the inclusion criteria and were considered for the analysis. A random-effect model showed that acute pulmonary embolism was present in 19.0% of Italian patients with COVID-19 infection. Moreover, these patients were at higher mortality risk compared with those without (odds ratio: 1.76, 95% confidence interval: 1.26–2.47, P = 0.001, I
2 = 0%). Sensitivity analysis confirmed yielded results.

Conclusion
In Italian patients with COVID-19 infection, acute pulmonary embolism was present in about one out of five and significantly associated with a higher mortality risk in the short-term period. The identification of acute pulmonary embolism in these patients remains critical to promptly identify vulnerable populations who would require prioritization in treatment and prevention and close monitoring.
Inflammation and heart failure: a two-sample Mendelian randomization study
Authors: Remmelzwaal Sharon , van Oort Sabine , Handoko M. Louis , van Empel Vanessa , Heymans Stephane R.B. , Beulens Joline W.J. 
Published: September 2022

Background
It is hypothesized that inflammation leads to heart failure. Results from observational studies thus far have been inconsistent and it is unclear whether inflammation is causally associated with new-onset heart failure. Mendelian randomization analyses are less prone to biases common in observational studies such as reverse causation and unmeasured confounding. The aim of this study was to investigate the causal relation between various inflammatory biomarkers with risk of new-onset heart failure by using a two-sample Mendelian randomization approach.

Methods
Ten inflammatory biomarkers with available genome-wide association studies (GWAS) among individuals of European ancestry were identified and included C-reactive protein (CRP), immunoglobulin E, tumour necrosis factor (TNF), toll-like receptor 4, interleukin 1 receptor antagonist, interleukin 2 receptor subunit α, interleukin 6 receptor subunit α, interleukin 16, 17 and 18. For the associations between the identified SNPs and heart failure, we used the largest GWAS meta-analysis performed by the Heart Failure Molecular Epidemiology for Therapeutic Targets Consortium with 47 309 participants with heart failure and 930 014 controls. For our main analyses, we used the inverse-variance weighted method.

Results
We included 63 SNPs. CRP, TNF, interleukin 2, 16 and 18 were not associated with heart failure with odds ratios (ORs) of 1.01 [95% confidence interval (95% CI: 0.94–1.09), 1.11 (95% CI: 0.80–1.48), 0.97 (95% CI: 0.93–1.02), 0.99 (95% CI: 0.96–1.03) and 1.01 (95% CI: 0.97–1.06), respectively. The other biomarkers were also not associated with the risk of heart failure and suffered from weak instrument bias.

Conclusion
This Mendelian randomization study could not determine a causal relationship between inflammation and risk of heart failure. However, some biomarkers suffered from weak instrument bias.
Discussion of cost continues to be uncommon in companion animal veterinary practice
Authors: Groves Catherine N. H. , Janke Natasha , Stroyev Alexandra , Tayce Jordan D. , Coe Jason B. 
Published: September 2022

Abstract

OBJECTIVE
To determine the prevalence and nature of cost conversations occurring during veterinarian-client-patient interactions within companion animal practice.

SAMPLES
60 randomly selected, practicing veterinarians working in 55 practices across southern Ontario, Canada, and 909 of their clients, sampled by convenience.

PROCEDURES
A cross-sectional descriptive study including 917 video-recorded appointments. Associations between veterinarian, client, or appointment-level factors and occurrence of a cost conversation were evaluated using multi-level logistic regression.

RESULTS
215 of 917 (23.4%) videos included a discussion of cost between the veterinarian and client. Cost conversations involving veterinarians primarily focused on conveying the price in relation to the time or service being offered (74.0% [159/215]), whereas the benefit to the future health and wellness of the patient was conveyed in 14.4% (31/215) of veterinarians’ cost conversations. Costs were most frequently discussed by veterinarians in relation to diagnostic testing (44.2% [96/215]). The odds of a cost discussion occurring were greater during problem appointments versus wellness (P = .011) or recheck (P = .029) appointments, for feline versus canine patients (P = .037), as appointment duration increased (P < .001), and as a client’s number of visits in the past year decreased (P = .049).

CLINICAL RELEVANCE
Discussing cost of care in veterinary practice continues to be relatively uncommon. Opportunities exist for veterinary professionals to frame their communication of the cost of veterinary care in relation to the benefits offered to the future health and wellbeing of the veterinary patient.