bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression and Function of Tumor Necrosis Factor- α-induced protein 8-like (TIPE) family in glioma
Authors: Chen Qiong , Liu Tiancai , Lin Li 
Published: July 2022

Abstract
Background: Although novel strategies of glioma are emerging sequentially, the effectiveness of novel treatment remains suboptimal at present. Therefore, profiles of molecular are needed for improving diagnosis, survival prediction and identification of therapeutic targets for glioma. Tumor necrosis factor-α-induced protein 8-like (TNFAIP8/TIPE) family members are involved in tumorigenesis and inflammatory responses but have been poorly studied in glioma. In this study, we aimed to investigate the expression and functions of TIPE family in glioma. Methods: The expression data of the TIPE family from the Chinese Glioma Genome Atlas (CGGA), the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were conducted to analyze TIPEs expression and functional networks in gliomas. Kaplan-Meier analysis and Cox regression were performed to access the overall survival of these genes. The related functional networks were identified using Gene Set Enrichment Analysis and LinkedOmics. The relationship between TNFAIP8 and tumor immune system were analyzed by TISIDB. Results: The results shown that TIPEs were generally expression in gliomas. Glioma patients with high TNFAIP8 levels tend to be more malignant than those with low expression and are associated with reduced survival. GSEA identified a variety of oncogenic and immune pathway that were tightly linked with TNFAIP8. TISIDB data found that TINAIP8 expression was significantly positively correlated with immune infiltrates cells and immune-related factors. Conclusions: TNFAIP8 exhibit crucial role in reduced survival in glioma and could serve as a potential prognostic biomarker. The present study revealed the expression patterns and potential functional networks of TNFAIP8 in glioma, providing insights for future research of the role of TNFAIP8 in carcinogenesis.
Non-diphtheriae Corynebacteria Causing Breast Abscess in Non-lactating Females Seeking to Avoid Pitfalls in Diagnosis of Chronic Breast Infections Through Diagnostic Stewardship
Authors: Sardana Raman , Butta Hena , Gilotra Kirti , Mendiratta Leena , Baweja Pankaj , Sarin Ramesh 
Published: July 2022

Background: Consideration of non-diphtheriae Corynebacteria as an infective organism in mastitis, is usually neglected. So, infections due to Corynebacterium species may remain undiagnosed or misdiagnosed. The aim of our study was to focus on non-diphtheriae Corynebacterium as causative organisms in breast infections using scientific logic and technology of Matrix Assisted Laser Desorption Ionisation Time of Flight Mass Spectrometry (MALDITOF MS) to categorize the isolates upto species level. The clinical correlation and response to management especially targeted antimicrobials was also recorded.
Methods: All the consecutive pus/tissue samples from Breast abscess received during study period were processed as per the standard guidelines. The identification of the isolate was done by automated methods. The cytopathological/histopathological and clinical details of the patients with infection due to Corynebacterium sp. were recorded and analyzed.
Results: Out of 52 non-duplicate samples, five showed growth of non-diphtheriae Corynebacteria. These were identified as C. kroppenstedtii and C. amycolatum. The antimicrobial susceptibility testing showed 100% susceptibility to Amoxicillin-clavulanate, Tetracycline, Vancomycin and Linezolid for all the five isolates. Histopathological examination was suggestive of chronic inflammatory mastitis/Granulomatous mastitis.
Conclusion: Non diphtheriae Corynebacteria particularly lipophilic Corynebacteria have a predilection to cause infections of breast tissue and Breast abscess which may mimic as tubercular abscess or chronic non-specific mastitis leading to unnecessary usage of antimicrobials. So, these isolates from breast tissue/pus should not be ignored rather definitely identified. This would also ensure diagnostic stewardship.
BRAFV600E Mutation in Papillary Carcinoma Thyroid
Authors: M S Bhuvitha , G Krishna 
Published: July 2022

Background: Thyroid malignancies comprise 1 % of total human malignancies, Papillary Thyroid Carcinoma (PTC) is the most common malignant tumour of thyroid cancers. It is estimated that 80 % of thyroid malignancies are comprised of papillary carcinoma thyroid, which shows increased incidence in women. The most important etiology of PTC is mutation of RET/RAS/BRAF which activates MAPK signaling pathway. The BRAF V600E activating point mutation appears to be highly specific for PTC.
Methods: It is cross sectional study of 56 cases studied in the Government Medical college, Thiruvananthapuram, Kerala. Consecutive cases of histo-pathologically proven cases were selected and Immunohistochemical (IHC) studies for BRAFV600E were conducted, and results were recorded.
Result: Our study showed female preponderance and equal distribution of cases above and below 45 years of age. Size of the primary tumour was more than 1cm for majority of cases. In our study out of 56 cases studied 45 patients showed BRAFV600E expression comprising of 80% positivity. A 44% of the total cases studied showed lymph node metastasis.
Conclusion: We conclude in our study that BRAFV600E mutation is most common mutation in primary PTC patients. BRAFV600E expression most seen in elderly patients and shows strong association with lymph node metastasis. IHC assay is a reliable method to detect BRAFV600E mutation in PTC and can be used as alternative to molecular methods on routine practice
Gut Microbiome and Health Assessment Due To Arsenic Toxicity: A Review
Authors: Abhishek jain  , Roshni jain  , Swati jain  , Subodh kumar jain  , Swati singh thakur  
Published: July 2022

Arsenic is considered as a class 1 carcinogen and first among toxicants ranked by the Environmental Protection Agency. Arsenic toxicity includes deleterious effect on gut microbiota, gastrointestinal disorder, immunological disturbances, disrupting metabolism and compromising the host health. Over 103–104 microorganisms with possibly 500 to 1,000 different species inhabit within the gut with 150 times more genes than the human genome. They help to digest food and play an essential role in our well- being. Gut microbiota affects our whole metabolism as well as the immune system of the host. Arsenic induced toxicity is a major health challenge leading to many neurological and immunological problems and inhibits the growth of many bacterial species common in the gastrointestinal tract. The Gut microbiome carries multiple functions that are beneficial to the hosts. Arsenic exposure will be a critical concern for human health. Human gut microbiomes may be biochemically responsible for arsenic metabolism, change in the arsenic compounds and several arsenical transformations that may lead to arsenic toxicity. Arsenic metabolism occurs in the liver by arsenic methyltransferase (AS3MT) which methylates it into the inorganic arsenic, and ultimately eliminated through urine. Recent studies showed that biotransformation of gut microbiome causes alteration of microbiome morphology and physiology that may alter the ArsBC gene activity due to arsenic toxicity. We aimed at summarising that arsenic induced perturbed gut microbiome communities that trigger systemic responses in diverse organs. Due to gut microbiota perturbation, changes in gut permeability and metabolism have been identified, and there is a shift in the population of gut bacterial species having arsenic resistant genes that result in disturbance of host metabolic homeostasis. Here we review known aspects of arsenic gut microbes' interaction, this will help to understand about arsenic toxicity with the gut microbiome and their deleterious effects.
The Combined Effectiveness of Piriformis Stretch and Muscle Activation Exercises in Patients with Sacroiliac Joint Pain.
Authors: Bhupendra Karki  , Abhijit Kalita  , Abhijit Dutta  
Published: July 2022

Sacroiliac joint pain is one of the common misdiagnosed orthopedic causes of low back pain, which affects between 15 to 30 percent of individuals with mechanical low back pain below L5. The sacroiliac joint is found out to be a source of dysfunction and pain in 10% to 27% of suspected cases of patients with chronic low back pain. Clinicians use different electrotherapy modalities, biomechanical correction techniques, and exercises for addressing SI joint pain. Many studies have been undertaken to find out the efficacy of different treatment tools in combination or isolation. Likewise, there are studies done to understand the effect of piriformis stretch and muscles activation exercises on sacroiliac joint pain but, there exists very little evidence studying the combined effect of both the treatment tools. So our study aims to determine the combined effect of piriformis stretch and muscles activation exercises in patients with sacroiliac joint pain. About 30 subjects, both male and female with a primary diagnosis of sacroiliac joint pain by the physician were recruited into two groups. Group A having 15 patients received piriformis stretch and muscles activation exercises, and Group B having 15 patients received only muscles activation exercises. All the subjects received therapy sessions thrice weekly for four weeks. Outcome measures used were the visual analog scale (VAS) and oswestry disability index(ODI). Pre- intervention assessment and post-intervention assessment was carried out for both groups and the received data was analyzed using paired and independent t-test. According to the results of the analysis, the average improvement of VAS for Group A and Group B were 2.33 and 3.53 respectively. The paired t-test was 23.129 and 14.270, which is statistically highly significant (p-value = 0.000). The average improvement in oswestry disability index for group A and group B were 16.13 and 26.13 respectively using mean and standard deviation. The paired t-test was 11.014 and 6.934 respectively, which is statistically highly significant (p-value = 0.000). There is a significant improvement in both Group A and Group B. However, Group A (piriformis stretch and muscle activation exercises) showed significant improvement in the treatment of sacroiliac joint pain. The results indicated that both Group A and Group B had significant improvement in the scores of VAS and ODI scores at the 4th week when compared to baseline values, but when comparing the end results of group A and group B, it has been found out that group A intervention is more effective than Group B in treating patients with sacroiliac joint pain. From the data analysis reports, it can be concluded that when these treatment tools i.e piriformis stretch and muscles activation exercises are applied in combination, it gives better results in the management of sacroiliac joint pain
FUNGSI TRADISI LAGU NENGGO DI DUSUN TUNGKU, DESA GOLO, KECAMATAN CIBAL, MANGGARAI SEBAGAI MEDIA PENGENDALIAN SOSIAL DAN POTENSINYA SEBAGAI SUMBER BELAJAR SOSIOLOGI DI SMA
Authors: Agas Albertus , Pageh I Made , Yasa I Wayan Putra 
Published: July 2022

Penelitian ini bertujuan untuk (1) Mengidentifiksi alasan penggunaan lagu Nenggo sebagai media pengendalian sosial di Dusun Tungku, Desa Golo, Kecamatan Cibal, Kabupaten Manggarai, Nusa Tenggara Timur. (2) Untuk mengetahui implementasian lagu Nenggo dalam upaya pengendalian sosial di Dusun Tungku. (3) Untuk mengetahui aspek-aspek yang terdapat pada lagu Nenggo yang berpotensi sebagai sumber belajar sosiologi di SMA. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Objek dalam penelitian ini adalah masyarakat Dusun Tungku, Desa Golo, Kecamatan Cibal, Kabupaten Manggarai, Nusa Tenggara Timur dengan informan kunci sebagai kepala adat, Kepala Dusun, Dewan Stasi serta tokoh adat dan tokoh agama yang berasal dari Dusun Tungku. Hasil penelitian menunjukan bahwa: (1) Tradisi lagu Nenggo dapat dijadikan sebagai media pengendalian sosial di Dusun Tungku berdasarkan karakteristiknya, fungsinya, cara-cara dan sifat pengendalian sosial. (2) Implementasi tradisi lagu Nenggo secara preventif yaitu mendidik, mengajak, melarang dan mengingatkan dan secara represif yaitu penyebaran rasa malu dan takut, sebagai media keritik sosial dan sebagai penguatan kepercayaan rakyat (3) Fungsi lagu Nenggo sebagai media pengendalian sosial berpotensi sebagai sumber belajar sosiologi di SMA sesuai dengan kompetensi dasar (KD) dan kompetensi inti (KI). Fungsi tradisi lagu Nenggo sebagai media pengendalian sosial juga memenuhi kompetensi siswa yaitu kompetensi kognitif, afektif dan pesikomotorik.
SOLIDARITAS SOSIAL NELAYAN PADA MASA PACEKLIK DI DESA RANDU PUTIH, KABUPATEN PROBOLINGGO DAN POTENSINYA SEBAGAI SUMBER BELAJAR SOSIOLOGI DI SMA
Authors: Ardiyansah Ahmad , Margi I Ketut , Yasa I Wayan Putra 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui bentuk solidaritas sosial masyarakat nelayan di Desa Randu Putih Kecamatan Dringu, Kabupaten Probolinggo pada masa panceklik, Untuk mengetahui faktor penghambat dan pendukung solidaritas sosial masyarakat nelayan di Desa Randu Putih Kecamatan Dringu, Kabupaten Probolinggo pada masa paceklik, Untuk mengetahui solidaritas sosial masyarakat nelayan pada masa paceklik di Desa Randu Putih Kecamatan Dringu, Kabupaten Probolinggo pada masa paceklik yang dapat digunakan sebagai sumber belajar sosiologi di SMA. Pada penelitian ini peneliti menggunakan pendekatan deskritif kualitatif dengan metode pengumpulan data berupa observasi, wawancara, dan studi dokumen/analisis content dan purposive sampling. Adapun jenis data yang digunakan terbagi menjadi dua yaitu data primier dan data sekunder. Berdasarkan penelitian yang telah dilaksanakan. (1) terdapat dua bentuk solidaritas sosial nelayan pada masa paceklik di Desa Randu Putih, Kabupaten Probolinggo yaitu kerjsama dan gotong royong. (2) adapun faktor penghambat solidaritas sosial pada masa paceklik Desa Randu Putih, Kabupaten Probolinggo yaitu dari faktor penghambat yaitu modernisasi, materialisme, faktor pendukung yaitu budaya, agama dan ikatan kelurga, (3) memberikan sumber belajar di luar buku teks. Hal ini bertujuan untuk memberikan wawasan terkait realitas kehidupan manusia dalam kelompok sosial, tentu ini menjadi cara yang lebih efektif agar proses pembelajaran tidak berkesan membosankan.
FUNGSI FOLAYA PADA ACARA FOKO’O SIMATE DALAM UPACARA KEMATIAN MASYARAKAT NIAS
Authors: Zebua Ayu Marnila , Rahayu Tuti 
Published: July 2022

Abstract - This study aims to describe the function of Folaya at the Foko'o Simate event in the traditional ceremony of the death of the Nias community, especially in Hiliweto village, Gido District, Nias Regency. The theory used in this study is the theory of M. Jazuli about the function of dance as a means of traditional ceremonies related to events in human life in the form of death. The population in this study is the Nias community in Hiliweto Village, Gido District, Nias Regency, such as traditional leaders, community leaders, artists and cultural experts. The sample refers to 6 people, namely 2 artists, 2 cultural observers, 1 traditional leader and 1 community leader who clearly know about Folaya at the Nias community death ceremony. The research method used in this research is descriptive qualitative method with data collection techniques in the form of observation, interviews and documentation in the field. In qualitative research methods, research results are described and described in accordance with the facts on the ground. The results of the study indicate that Folaya functions as a means of traditional ceremonies in the Nias community's death ceremony which is a medium for conveying respect to someone who has died. Keywords: Folaya, Function, Death Ceremony Abstrak – Penelitian ini bertujuan untuk mendeskripsikan fungsi Folaya pada acara Foko’o Simate dalam upacara adat kematian masyarakat Nias khususnya di desa Hiliweto, Kecamatan Gido, Kabuparen Nias. Teori yang digunakan dalam penelitian ini adalah teori dari M. Jazuli tentang fungsi tari sebagai sarana upacara adat yang berkaitan dengan peristiwa kehidupan manusia berupa kematian. Populasi dalam penelitian ini yaitu masyarakat Nias yang ada di Desa Hiliweto, Kecamatan Gido, Kabupaten Nias seperti tokoh adat, tokoh masyarakat, seniman dan budayawan. Sampel merujuk pada 6 orang yaitu 2 seniman, 2 budayawan, 1 tokoh adat dan 1 tokoh masyarakat yang mengetahui secara jelas tentang Folaya pada upacara kematian masyarakat Nias. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi di lapangan. Dalam metode penelitian kualitatif, hasil penelitian digambarkan dan diuraikan sesuai dengan fakta yang ada di lapangan. Hasil penelitian mengatakan bahwa Folaya berfungsi sebagai sarana upacara adat dalam upacara kematian masyarakat Nias yang menjadi media penyampaian rasa hormat kepada seseorang yang sudah meninggal. Kata Kunci: Folaya, Fungsi, Upacara Kematian.
Establishment of a Technology Exchange Operated under Enterprise Model
Authors: Long Luu Hoang 
Published: July 2022

Technology Exchange (TEx) is an operating model to commercialize research results; support and advise science and technology (S&T) organizations and businesses in technology exchange and transfer, and act as a bridge between the research and development (R&D) activities and production/business sector.
There have been many studies on the operating model of the Technology Exchange, the commercialization of research results and the policies for technology market development in Viet Nam. However, these studies have not yet shown any specific and feasible operating model for the operation of the Technology Exchange.
This paper analyzes the theoretical and practical basis to propose the establishment of a business-driven Technology Exchange model to develop the technology market in Vietnam.
Promoting Inclusive Education for Girls with Disability: Reviewing Theoretical and Legal Framework
Authors: Thi Nhu Trang Nguyen , Thi Thanh Huong Nguyen , Trung Hai Nguyen , Thi Hong Hanh Nguyen 
Published: July 2022

Education plays a vital role in the comprehensive development of children as well as community’s prosperity. However, access to education services remains a challenge for children with disabilities, especially girls due to issues such as stigmatization and cultural and institutional obstacles. This paper reviews the current social policies which support girls with disability accessing education in Vietnam and examines some foundational theoretical frameworks for building these social policies, namely disability approach, feminism approach, and inclusive education approach. On that basis, the paper provides some recommendations to strengthen the impact of current social policies on promoting inclusive education for girls with disabilities.
Keywords
Girls with disabilities, education policies, human right approach, inclusive education, anti-oppression model.
Proposed Solutions to Enhance Lecturers’s Adaptation to E-learning in the Context of COVID-19 Pandemic (A Case Study at the VNU University of Social Sciences and Humanities – Vietnam National University, Hanoi)
Authors: Thi Lan Nguyen 
Published: July 2022

Since March 2020, due to the outbreak of the COVID-19 pandemic, to continue students’ education while controlling the spread of COVID-19, the higher education system has been required to switch from face-to-face learning model to a virtual one. In Vietnam, although e-learning has already been introduced, it has been actively adopted since the COVID-19 pandemic occurred. The transition to e-learning in the context of the COVID-19 outbreak while lacking preparation for this teaching mode has put lecturers and students in a passive position with many difficulties. This article presents the situation of virtual learning adoption and implementation by lecturers at the University of Social Sciences and Humanities (Vietnam National University, Hanoi) in recent years and their associated challenges. Based on the situation analysis, this article suggests a number of potential solutions to enhance the adaptability of lecturers and improve the effectiveness of e-learning. These solutions will contribute to the better preparation of lecturers and educational administrators for immediate and effective responses to similar adverse events in the future, from that ensure the quality of higher education.
Keywords:
Solution, adaptation; lecturer, e-learning; COVID-19 pandemic.
Formulating Policy on a Strength-based Support Program for Family Caregivers of People with Dementia at the Hospital Level
Authors: Thu Trang Nguyen 
Published: July 2022

To address psychological challenges of family caregivers of people with dementia, this article aims to formulate a policy for this target group at the hospital level. Policy formulation is one of the five steps in the policy process, including: i) Agenda setting; ii) Policy formulation; iii) Decision making; iv) Policy implementation; and v) Policy evaluation. The proposed policy focuses on addressing the lack of psychological services and interventions which are self-concept based and strength-based in order to help caregivers cope with and adjust to their caregiving burden. This policy consists of two key action plans: i) Expanding the existing intervention with a supplement of the self-concept and strength-based components; and ii) Establishing support groups of family caregivers of people with dementia. These action plans were assessed using the Matrix 5W of policy formulation. The results show high acceptance and feasibility of the action plans at the hospital level. In addition, their benefits were found to be outweigh the costs. These results serve as evidence for the decision making of the stakeholders.
Keywords:
Policy process, policy formulation, dementia, Alzheimer’s disease, hospital, family caregivers.
Fostering Research Integrity in Social Sciences: Basic Understanding and Policy Recommendations
Authors: Hoang Thanh Lan Dang 
Published: July 2022

There are numerous definitions of "Research Integrity", but we chose a definition that indicates the role of institutional environment and policies in ensuring fairness and honesty in research activities. This article is an overview of the historical context and current needs to build workable policies on research integrity. Core values, common actions of compliance and violations in practicing research integrity will also be presented. Besides synthesizing basic knowledge of these matters, we propose to use responsive regulatory theory to develop sanctions policies. The application of this theoretical framework is shown in a specific example, the University of Leicester's regulations on plagiarism. Principles of the responsive regulatory theory are expected to be applicable for other research misconducts.
Keywords
Research integrity, research misconduct, sanctions policy, responsive regulatory theory