bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stationary and Transient Asymmetric Features in Tropical Cyclone Eye with Wavenumber-1 Instability: Case Study for Typhoon Haishen (2020) with Atmospheric Motion Vectors from 30-Second Imaging
Authors: Horinouchi Takeshi , Tsujino Satoki , Hayashi Masahiro , Shimada Udai , Yanase Wataru , Wada Akiyoshi , Yamada Hiroyuki 
Published: October 2022

Abstract
Dynamics of low-level flows in the eye of Typhoon Haishen (2020) in its late phase of intensification are investigated with a special rapid-scan observation of the Himawari-8 geosynchronous satellite conducted every 30 s. This is accomplished by deriving storm-relative atmospheric motion vectors at an unprecedentedly high spatiotemporal resolution by tracking clouds across five consecutive visible-light reflectivity. The overall low-level circulation center was situated several kilometers away from the storm center defined in terms of the inner edge of the lower part of eyewall clouds. The shift direction is rearward of the storm translation, consistently with a numerical study of the tropical cyclone (TC) boundary layer. Over the analysis period of 10 h, azimuthal-mean tangential wind around this center was increased at each radius within the eye, and the rotational angular velocity was nearly homogenized. The instantaneous low-level circulation center is found to orbit around the overall circulation center at distances around 5 km. Its orbital angular speed was close to the maximum angular speed of azimuthal-mean tangential winds. This rotating transient disturbance is found to transport angular momentum inward, which explains the tangential wind increase and the angular velocity homogenization in the eye. These features are consistent with an algebraically growing wavenumber-1 barotropic instability, whose impact on TC structures has not been explored. This instability enhances wavenumber-1 asymmetry in ring-shaped vorticity, which can be induced by various processes such as translation, environmental shear, and exponential barotropic instability. Therefore, it may appear broadly in TCs to affect wind distribution in their eyes.

Significance Statement
Axially asymmetric transient features in the inner cores of tropical storms have been suggested to profoundly affect the structures and the time evolutions of tropical storms. However, the scarcity of observations has hindered studying such processes observationally. By using a specially conducted high-frequency satellite imaging of Typhoon Haishen (2020), we derived atmospheric motion vectors nearly homogeneously at an unprecedentedly high spatiotemporal resolution. Various kinds of asymmetric motions in low-level flows in the eye were found. Of particular interest is a special type of wavenumber-1 instability whose role has not drawn much attention; the instability was found to provide angular momentum transport consistent with the measured homogenization of the rotation.
Pseudoaneurysm Screening after Pediatric High Grade Solid Organ Injury
Authors: Schellenberg Morgan , Emigh Brent , Nichols Chance , Dilday Joshua , Ugarte Chaiss , Onogawa Atsushi , Shapiro Doug , Im Daniel D. , Inaba Kenji 
Published: October 2022

Background High grade solid organ injuries carry risk of complications, including pseudoaneurysms (PSA). The optimal approach to PSA screening among pediatric patients is unknown and may include delayed Computed Tomography Angiography (dCTA) and/or contrast-enhanced ultrasound (CEUS). This study endeavored to define dCTA/CEUS yield in PSA diagnosis after pediatric high grade solid organ injury. Methods Patients <18y presenting to our ACS-verified Level 1 trauma center with ≥1 AAST grade ≥3 abdominal solid organ injury (kidney, liver, and spleen) were included (01/2017-10/2021). Transfers in, death <48h, and immediate nephrectomy/splenectomy were exclusions. PSA screening was pursued selectively based on attending discretion. Demographics, clinical/injury data, and outcomes were collected. Primary outcome was performance of dCTA or CEUS. Results Forty-two patients satisfied criteria, with median age 12.5y and ISS 22. Liver injuries were most frequent (48%), followed by spleen (33%) and kidney (19%). Initial management strategy was most commonly nonoperative (liver 60%, spleen 64%, kidney 75%). Overall, 26% underwent PSA screening at a median of hospital day 4, with dCTA (21%) or CEUS (5%). CEUS was only used among liver injuries (10%), with no PSA identified. One PSA was diagnosed on dCTA after splenic injury and was managed with observation. Conclusion PSA screening occurs infrequently after pediatric high grade solid organ injury, potentially due to concerns about radiation exposure from dCTA which would be mitigated with CEUS. Further delineation of PSA incidence and yield of screening investigations are needed to avoid missing this important diagnosis and to determine the diagnostic accuracy of dCTA and CEUS.
The prevalence of excess weight among Vietnamese adults: A pooled analysis of 58 studies with more 430 thousand participants over the last three decades
Authors: Phuc Tran Thai , Duc Tran Quang , Quynh Chi Vu Thi , Quang Phan Ngoc 
Published: October 2022

Background Chronic noncommunicable diseases (NCDs) associated with excess weight as a significant risk factor, but few studies have been sufficient enough to examine the magnitude of excess weight of Vietnamese adults. This review aimed to provide a generalized estimate of the prevalence of excess weight among Vietnamese adults. Methods PubMed, Scopus and national database were used to identify articles published up to May 2022. The Newcastle-Ottawa Quality Assessment Scale was used to rate the study quality. The data was analyzed using RStudio software, and the combined effects were estimated using random-effects meta-analysis. The Cochran's Q-test and the I2 test were employed to examine heterogeneity, and subgroups were conducted. Egger's test and visual inspection of the symmetry in funnel plots were used to determine publication bias. Results 58 studies with 432,585 participants from 1998 to 2020 were suitable for inclusion in the final model after meeting the prerequisites. Over the last three decades, the combined pooled prevalence of excess weight among adults in Vietnam was 20.3% (95% CI: 15.2–26.6). Notably, this proportion has a tendency to go up between 1998 and 2020. Moreover, rates of excess weight were found to be substantially higher in non-national studies (23.1%, 17.3–30.1) compared to national studies (8.4%, 3.6–18.3) and significantly higher when Asian and Pacific cut-offs (27.6%, 20.0–36.7) were used rather than WHO classification (11.2%, 6.7–18.0). Conclusion The findings suggest healthcare professionals and policymakers should focus more on designing and implementing preventive initiatives to lower the rising prevalence of excess weight adults in Vietnam.
CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial
Authors: Gibson C. Michael , Kazmi Syed Hassan A. , Korjian Serge , Chi Gerald , Phillips Adam T. , Montazerin Sahar Memar , Duffy Danielle , Zheng Bo , Heise Mark , Liss Charles , Deckelbaum Lawrence I. , Wright Samuel D. , Gille Andreas 
Published: October 2022

Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I formulated with phosphatidylcholine (PC). CSL112 is intended to improve CEC and thereby prevent early recurrent cardiovascular events following AMI. AEGIS-I (ApoA-I Event Reducing in Ischemic Syndromes I) was a multicenter, randomized, double-blind, placebo-controlled, dose-ranging phase 2b study, designed to evaluate the hepatic and renal safety of CSL112. Here, we report an analysis of a pharmacokinetic (PK) and pharmacodynamic (PD) substudy of AEGIS-I. Methods: AMI patients were stratified by renal function and randomized 3:3:2 to 4, weekly, 2-hour infusions of low- and high-dose (2 g and 6 g) CSL112, or placebo. PK/PD assessments included plasma concentrations of apoA-I and PC, and measures of total and ABCA1-dependent CEC, as well as lipids/lipoproteins including high density lipoprotein cholesterol (HDL-C), non-HDL-C, low density lipoprotein cholesterol (LDL-C), ApoB, and triglycerides. Inflammatory and cardio-metabolic biomarkers were also evaluated. Results: The substudy included 63 subjects from AEGIS-I. CSL112 infusions resulted in rapid, dose-dependent increases in baseline corrected apoA-I and PC, which peaked at the end of the infusion (Tmax ≈ 2 hours). Similarly, there was a dose-dependent elevation in both total CEC and ABCA1-mediated CEC. Mild renal impairment did not affect the PK or PD of CSL112. CSL112 administration was also associated with an increase in plasma levels of HDL-C but not non-HDL-C, LDL-C, apoB, or triglycerides. No dose-effects on inflammatory or cardio-metabolic biomarkers were observed. Conclusion: Among patients with AMI, impaired CEC was rapidly elevated by CSL112 infusions in a dose-dependent fashion, along with an increase in apoA-I plasma concentrations. Findings from the current sub-study of the AEGIS-I support a potential atheroprotective benefit of CSL112 for AMI patients.
Follow-Up Care After Maltreatment: Sociodemographic Associations With Timeliness in a Southern State
Authors: Calvert Maegan L. , Korgaonkar Siddhi , Ramachandran Sujith , Sarver Dustin E. 
Published: October 2022

Children who experience maltreatment are at elevated risk of developing mental health difficulties. Even so, they often do not receive timely, evidenced-based mental health treatment, which may exacerbate the risk of poor outcomes. This study aims to describe the receipt of timely follow-up care after maltreatment in a southern state with known treatment shortages and aims to identify factors associated with timely follow-up care. We utilized a retrospective cohort design using 2014 Mississippi Medicaid administrative claims data for youth 0–18 years. Prevalence estimates and associations with definite and probable maltreatment (based on recorded age/injury combinations) during inpatient and outpatient healthcare encounters were evaluated. Rates of 30-day maltreatment follow-up with any medical or behavioral health provider were also assessed. Prevalence estimates of definite and probable maltreatment in the eligible study population ( N = 324,752) were 0.53% and 3.8%, respectively. Only one-third of identified children received 30-day follow-up. Black and older children as well as children diagnosed with anxiety or depression were more likely to receive 30-day follow-up than younger children, white children, and children without anxiety or depression. Low rates of timely follow-up indicate the need for intentional workflow practices to increase the likelihood of follow-up.
Determinants of Hospital Use and Physician Services Among Adults With a History of Homelessness
Authors: Wiens Kathryn , Rosella Laura C , Kurdyak Paul , Chen Simon , Aubry Tim , Stergiopoulos Vicky , Hwang Stephen W 
Published: October 2022

Background: People experiencing homelessness have diverse patterns of healthcare use. This study examined the distribution and determinants of healthcare encounters among adults with a history of homelessness. Methods: Administrative healthcare records were linked with survey data for a general cohort of adults with a history of homelessness and a cohort of homeless adults with mental illness. Binary and count models were used to identify factors associated with hospital admissions, emergency department visits and physician visits for comparison across the 2 cohorts. Results: During the 1-year follow-up period, a higher proportion of people in the cohort with a mental illness used any inpatient (27% vs 14%), emergency (63% vs 53%), or physician services (90% vs 76%) compared to the general homeless cohort. People from racialized groups were less likely use nearly all health services, most notably physician services. Other factors, such as reporting of a regular source of care, poor perceived general health, and diagnosed chronic conditions were associated with higher use of all health services except psychiatric inpatient care Conclusion: When implementing interventions for patients with the greatest health needs, we must consider the unique factors that contribute to higher healthcare use, as well as the barriers to healthcare access.
Association between free sugars intake and early psychopathological problems
Authors: Voltas Núria , Jardí Cristina , Hernández-Martínez Carmen , Arija Victoria , Canals Josefa 
Published: October 2022

Mental health problems are highly prevalent in childhood and adolescence and may be associated with nutritional intake. It has recently been shown that a high percentage of infants and children consume large amounts of free sugars. In this paper, we analyse the relationship between free sugar consumption at 12 and 30 months and the risk of developing psychological problems at 30 months in a community sample of 86 children evaluated longitudinally. Socio-family and anthropometric data, and the amount of free sugars consumed were collected at both ages. At 30 months, the Child Behavior Checklist 1.5–5 was administered to parents and an interview was conducted to identify psychological disorders in accordance with DC: 0–3’s classification. We report a relationship between high free sugar consumption at 30 months and the concurrent presence of sleeping problems, ADHD and anxiety symptoms. However, no significant association was observed between free sugar consumption at 12 months and the subsequent development of psychological problems. Early detection of emotional and behavioural manifestations and high sugar consumption in children may help to prevent the persistence of psychological problems.
Accuracy of CT perfusion-predicted core in the late window
Authors: Vidovich Johnathan , Voleti Sriharsha , Zhang Bin , Stephens Cody , Sriwastwa Aakanksha , Aziz Yasmin , Corcoran Brendan , Khandwala Vivek , Mistry Eva , Khatri Pooja , Wang Lily L , Vagal Achala 
Published: October 2022

Background and Purpose Recent endovascular trials have spurred a paradigm shift toward routine use of CT perfusion (CTP) for decision-making in acute ischemic stroke. CTP use in the late window, however, remains under evaluation. Our objective was to assess the accuracy of CTP-predicted core in the late window. Methods In a retrospective review of our prospectively identified stroke registry at a single, comprehensive stroke center, we included patients with anterior large vessel occlusions presenting within the 6-24 h window who underwent baseline CTP evaluation and achieved TICI2b or TICI3 reperfusion on endovascular treatment. We recorded baseline CTP-predicted core volumes at relative cerebral blood flow (CBF) thresholds of <30% <34%, and <38% using RAPID software. Final infarct volumes (FIV) were calculated using follow up MRI and CT, obtained within 72 h after stroke onset. Results Of the eligible patients, 134 met our inclusion criteria. Mean FIV was 39.5 (SD 49.6). Median CTP to reperfusion time was 93.5 min. Median absolute differences between CTP-predicted core and FIV were 14.7, 14.9, and 16.0 ml at <30%, <34%, and <38%, respectively. Correlation between CTP-predicted ischemic cores and FIV was moderate and statistically significant at all thresholds: r = 0.43 (p <0.001), r = 0.43 (p <0.001), and r = 0.42 (p <0.001) at the <30%, <34%, and <38% cutoffs, respectively. Conclusion CTP cores in the 6–24 h period underestimate FIV, especially with larger infarcts. CTP-predicted core volumes in the late window show moderate positive correlation with FIV.
Repeated mechanical thrombectomy for recurrent large vessel occlusion: A systematic review and meta-analysis
Authors: Elfil Mohamed , Bahbah Eshak I , Bayoumi Ahmed , Aladawi Mohammad , Eldokmak Mohamed , Salem Mohamed M , Aboutaleb Pakinam E , Villafuerte-Trisolini Brian , Al-Mufti Fawaz , Ortega-Gutierrez Santiago , A Gonzalez-Castellon Marco 
Published: October 2022

Background Mechanical thrombectomy (MT) is the standard treatment for acute large vessel occlusion (LVO). Recurrent LVO can still occur in patients who already underwent MT for the first LVO. This study aimed to evaluate the efficacy of repeating MT for recurrent LVO. Methods This meta-analysis of the available literature was conducted to summarize the current evidence regarding repeated MT outcomes in patients with recurrent LVO. All studies with ≥ 1 outcomes of interest were included. The Newcastle-Ottawa Scale (NOS) was used for risk of bias assessment. Results Twenty studies, 10 observational (n = 21,251 patients) and 10 case reports (n = 10 patients), were included. 266 patients (62.78% females) with recurrent LVO were identified, with an overall prevalence of 1.6% and a mean age of 65.67 ± 16.23 years. Cardio-embolism was the most common mechanism in both times, with a median of 15 days between the first and second LVOs. Compared with pre-intervention, the first and second MTs significantly reduced the National Institute of Health Stroke Scale (NIHSS) score, (mean difference (MD) = −8.91) and (MD = −5.97) respectively, with a significant difference (p = 0.001). The rate of favorable outcome (modified Rankin scale (mRS) score 0–3) was 82.6% and 59.2% after the first and second MTs respectively, with a significant difference (p < 0.001). Conclusion In properly selected recurrent LVO patients, repeated MT is efficacious and safe. A prior MT procedure should not discourage aggressive treatment as many patients may achieve favorable outcomes.
Building Thermal Insulation—Biodegradable Sugarcane and Coconut Fiber
Authors: Manohar Krishpersad , Yarbrough David W. , Kochhar Gurmohan S. 
Published: October 2022

Apparent thermal conductivity, Λ, measurements were conducted on sugarcane and coconut fiber specimens using LaserComp “FOX 304” and Holometrix “Rapid-k” heat-flow meters. Both heat-flow meters were built and operated in accordance with ASTM C 518. The Λ measurements for sugarcane and coconut fiber were investigated over the density ranges 70 to 120 kg/m3 and 40 to 90 kg/m3 over the mean test temperature ranges 18 to 32°C and 13.2 to 21.8°C, respectively. The experimental results for sugarcane and coconut fiber indicated the general trend associated with that of loose-fill thermal insulation. Using the Method of Least Squares, empirical relationships for calculating Λ. as a function of temperature and density for sugarcane and coconut fiber were developed. The percentage deviation of the measured apparent thermal conductivities from the empirical relation ships was less than ±3% for both sugarcane and coconut fiber. The results indicated that sugarcane and coconut fiber show minimum Λ at 100 kg/m3 and 80 kg/m3, respectively. The minimum Λ vary with temperature and ranged from 0.046 W/m.K to 0.049 W/m·K and 0.048 W/m·K to 0.049 W/m·K, respectively. The minimum apparent thermal conductivities of both sugarcane and coconut fiber are within the range of those normally associated with building thermal insulation.
The challenges of mental health of staff working with people with intellectual disabilities during COVID-19––A systematic review
Authors: Chen Yaohua , Allen Andrew P. , Fallon Marianne , Mulryan Niamh , McCallion Philip , McCarron Mary , Sheerin Fintan 
Published: October 2022

Background The COVID-19 pandemic has posed a great risk to the mental health of health workers (HWs). There are likely to be particular concerns for staff working with adults with an intellectual disability, where infection control may be more challenging. Method We conducted a systematic review of original research examining the mental health of HWs working with people with intellectual disability, published between March 2020 and July 2021. Results Five original research studies were included. A high proportion of HWs working with people with intellectual disability reported having had poor mental health including stress, anxiety, and depression. This manifested in similar patterns as for other HWs and also some specific patterns seen as the need to manage increased rates of mental health issues of the people they support. Sources of support and resilience were also identified. Conclusion The support system should target risk factors, answer unmet needs, and build resilience. More research is also required on the ongoing and long-term effects.
A prospective, open-label, multicenter phase IV clinical trial on the safety and efficacy of lobaplatin-based chemotherapy in advanced breast cancer
Authors: Yan Min , Yuan Peng , Ouyang Quchang , Cheng Ying , Han Guohui , Wang Dewei , Ran Li , Sun Tao , Zhao Da , Bai Yuju , Yang Shun’e , Wang Xiaojia , Wu Rong , Zeng Xiaohua , Yao Herui , Ji Xuening , Jiang Jun , Hu Xiaohua , Lin Haifeng , Zheng Liping , Zhu Zhitu , Ge Wei , Yang Junlan , Cui Tongjian , Zhang Xiaozhi , Lu Fangyang , Li Wenhui , Xu Hongyan , Kang Mafei , Gong Ping , Zou Liqun , Liu Jiang , Zhang Hongliang , Yu Hao , Xu Binghe 
Published: October 2022

Background: Since lobaplatin (LBP) has been approved to treat metastatic breast cancer in China, this study aimed to evaluate the safety and efficacy of LBP-based chemotherapy in clinical practice. Methods: This trial was a prospective, open-label, multicenter phase IV clinical trial that enrolled patients with unresectable locally advanced or recurrent/metastatic breast cancer from 34 sites between July 2013 and March 2017. Patients were treated with LBP monotherapy or in combination for four to six cycles. The primary endpoint was safety. Secondary endpoints included progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR). Results: A total of 1179 patients were analyzed; 59 (5.0%) were treated with LBP alone, 134 (11.4%) with LBP plus paclitaxel, 263 (22.3%) with LBP plus docetaxel, 237 (20.1%) with LBP plus gemcitabine, 403 (34.2%) with LBP plus vinorelbine, and 83 (7.0%) with other LBP-based regimens. The overall incidence of adverse events (AEs) was 95.2%, and 57.9% of patients had grade >3 AEs. The most common grade >3 AEs were neutropenia (43.9%), leukopenia (39.4%), anemia (17.8%), and thrombopenia (17.7%). LBP monotherapy showed the lowest incidence of grade >3 AEs (39.0%), followed by LBP plus docetaxel (52.9%), LBP plus paclitaxel (59.0%), LBP plus vinorelbine (62.5%), and LBP plus gemcitabine (62.9%). The ORR and DCR were 36.8 and 77.0%, respectively. The median PFS was 5.5 months (95% confidence interval: 5.2–5.9). Conclusion: LBP-based chemotherapy shows favorable efficacy in patients with advanced breast cancer, with manageable safety profile. Trial registration: This trial was registered with ChiCTR.org.cn, ChiCTR-ONC-13003471.
Iran’s Foreign Policy toward Tajikistan: Exploring the Effective Factors
Authors: Karimi Mahdi , Osuli Odlu Qasem 
Published: October 2022

After the independence of the Central Asian (CA) republics, Iran has tried to develop its relations with these sates, especially with Tajikistan. The development of bilateral relations between Iran and Tajikistan has been very important for both sides. But after nearly 30 years of political relations between Iran and Tajikistan, bilateral relations have not developed much and have faced numerous limitations. By adopting Rosenau’s theory, the current study aims at investigating Iran’s foreign policy (FP) toward Tajikistan and the factors influencing the bilateral relations between the two countries. The present paper argues that societal, governmental, idiosyncratic, and role variables, respectively, have hindered the development of bilateral relations between Iran and Tajikistan. Finally, systemic variables have had the least influence on Iran’s relations with Tajikistan, and the results show that the U.S. and its sanctions have had insignificant effect on Iran–Tajikistan bilateral relations, and in terms of the systemic variables, Iran has faced more opposition from China than any other country in the development of relations with Tajikistan.