bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical and Anti-Inflammatory Potential of Anredera cordifolia (Ten): A Review
Authors: Firdaus Mutiara Nurul Aulia , Kardela Widya , Ifora Ifora 
Published: March 2022

Objective : Inflammation is a manifestation of the immune response to eliminate antigens from the body. This process will occur until the antigen is eliminated from the body. This inflammatory process can occur locally or systemically. Anredera cordifolia (Ten) has been used as a traditional medicine as a therapy for inflammation, diabetes, kidney failure, hypertension, hyperlipidemia, and others. Therefore, this review aims to provide current information and obtain a comprehensive review of the anti-inflammatory activity of Anredera cordifolia (Ten).
Methods : This review provides evidence in the literature for the phytochemical and anti-inflammatory activity of Anredera cordifolia (Ten), from August 2011-August 2021. Three bibliographic databases were used as the main sources of information (Pubmed, ScienceDirect, and Google scholar). The keywords used in this research are as follows: “Phytochemical”, “anti-inflammatory”, “Bioactive compounds”, “Pharmacology” and “Anredera cordifolia”.
Results: A total of 10 studies were included in this review according to the required criteria, 5 of which were concerning phytochemical and 5 were concerning anti-inflammatory. Anredera cordifolia (Ten) contains many secondary metabolites such as essential oil, saponins, phenolics, rauninflammatory activity of Anredera cordifolia (Ten) occur mainly through several mechanisms including a decrease in the volume of paw edema, inhibition of hemolysis, inhibition of the inflammatory mediators TNF-α, IL-1β, IL-6, and NO, and a decrease in the number of neutrophil PMNs.
Conclusions: Recent interest in the traditional treatment of the Anredera cordifolia (Ten) plant both in vitro and in vivo has shown potential anti-inflammatory activity attributed to the presence of natural bioactive compounds.
Keywords : Anti-inflammatory, Anredera, Phytochemical, Pharmacology
Oral Dissolving Films: A Comprehensive Review on Recent Perspectives and Current Approach to Effective Drug Delivery
Authors: Saxena Arushi , Singh Taruna 
Published: March 2022

Oral dissolving films are advanced oral dosage forms implied for the attachment onto the buccal mucosa and have both local and systemic effects. These dosage forms may be favored over other oral drug delivery systems in terms of flexibility and comfort. These films utilize the property of bioadhesion of certain polymers, which on hydration target a particular region of the body for extended period of time thereby bypassing first pass metabolism and promoting increased bioavailability. These films are self-administrable, pharmacoeconomic and have good patient compliance. Various techniques may be used for the formulation of oral dissolving films, among which solvent casting method is the most preferable. Usually hydrophilic polymers along with other excipients are used to formulate buccal films, which disintegrate quickly releasing the incorporated APIs within seconds. Oral dissolving films offer numerous benefits as far as accessibility, administration and withdrawal, retentivity, low enzymatic movement, economy and high patient compliance is concerned, thus having the potential for market and business exploitation. This preset review emphasizes on mechanism of action, merits, composition, formulation, evaluation, marketed formulations of oral dissolving films. Additionally, covering the aspects related to novel fast dissolving techniques.
Keywords: Solvent casting method, buccal films, bioadhesion, hydration, bioavailability.
Dental Health Status of Early Childhood Patients in Dental Health Care Clinics
Authors: Fadjeri Indrayati , Purnama Tedi , Nurwanti Widi 
Published: March 2022

Background: Dental health problems in early childhood are higher than adults, so they need serious attention. Dental health status is a condition that describes the percentage and degree of health in the community. standard indicator of the World Health Organization to measure the status of dental caries using the def-t index. PHP-M index to measure dental hygiene status in mixed dentition. Objective: This study aims to determine the dental health status of early childhood patients in dental health care clinics. Methods: This research is a descriptive study with a cross sectional design. The sampling technique used was purposive sampling with 37 respondents. The data collection instrument used a questionnaire to measure dental health knowledge, an observation sheet brushing teeth to measure brushing skills, PHP-M index to measure dental hygiene status and def-t index to measure dental caries status. This research is processed and analyzed and presented in a frequency distribution. Results: Most of the early childhood children in dental health care clinics had less knowledge (54.1), less brushing skills (54.4), moderate dental hygiene status (64.9) and high dental caries status (75.7) Conclusion: Dental health status in early childhood patients in dental health care clinics is in the moderate category.
Keywords: Dental health status, eaely childhood, patients, dental health care clinics
Pharmacological Activities of Punicalagin: A Review
Authors: Rozadi Novia , Oktavia Sri , Fauziah Fitra 
Published: March 2022

Traditional medicine was becoming more popular as a component of complementary and alternative medicine around the world. The ability to provide information on the pharmacological effects of plants requires a thorough understanding of the chemical components found in plants. One of the chemical compounds reported having pharmacological activity was punicalagin. Punicalagin was a polyphenol compound found in Punica granatum, Lafoensia pacari, and genus Terminalia. This review provides information on the pharmacological activities of punicalagin. The bibliographic databases used as the sources of information were PubMed, Google Scholar, and ScienceDirect. The pharmacological activities of punicalagin have been reported as anticancer, antioxidant, hepatoprotective, antimicrobial, antivirus, neuroprotective, antiinflammation, gastroprotective, pre-eclampsia, antidiabetic, and anti hyperlipidemia.
Keywords: Punicalagin, Antioxidant, Anticancer, Antivirus.
The effectiveness of the application of the mentoring module on brushing teeth by parents on the behavior of brushing teeth in early childhood
Authors: Widiyastuti Rini , Purnama Tedi , Laut Deru Marah 
Published: March 2022

Background: Ability and good habits in maintaining dental health must be trained from an early age. In early childhood, there are deciduous teeth that must be maintained and maintained in order to stay healthy and support children to grow and develop optimally. At the age of 6 years will begin to grow permanent teeth that will be used for life. Therefore, children need to be equipped with knowledge and skills in maintaining oral health independently. Parents, especially mothers, are the closest people to children who will provide assistance and guidance to early childhood children in carrying out dental health maintenance, in connection with children who are not yet able to do it themselves. Objective: This study aims to analyze the effectiveness of the application of the brushing mentoring module on improving tooth brushing behavior in early childhood. Methods: this study used a quasi-experimental with a pretest and posttest with one group design. This research was conducted at Pertiwi VI Kindergarten Pondok Labu. The independent variable: the application of the brushing mentoring module and the dependent variable: knowledge, early childhood tooth brushing skills, knowledge and attitudes of parents. Data were tested using Wilcoxon. Result: the application of the mentoring module on brushing teeth was proven to be significantly (p<0.001) effective in increasing the knowledge and skills of brushing teeth for early childhood as well as increasing the knowledge and attitudes of parents. Conclusion: the brushing teeth mentoring module is effective in increasing tooth brushing behavior in early childhood.
Keywords: Brushing mentoring module, behavior, early childhood.
IMPLEMENTASI PROBLEM-BASED LEARNING BERBANTUAN ICT UNTUK MENINGKATKAN KEMAMPUAN PEMAHAMAN MATEMATIS SISWA SMK
Authors: Ariyanti Wati , Sugandi Asep Ikin 
Published: March 2022

This is the classroom action research which aims to determine the improvement of the mathematical understanding ability of XI-class students, through the problem-based learning method assisted by ICT. The subjects in this study were XI AKL 1 students of SMKN 11 Bandung, which involved 24 students. This classroom action research consists of 3 cycles, namely cycles I – III with 2 meetings each. The instrument used in data collection is the results of LKPD 1-3. Techniques in presentation data using descriptive tables in the form of averages and percentages. The study results indicate Problem-Based Learning implementation can gain students' mathematical understanding ability. The first cycle progress is specified by the increase in learning outcomes with the score average of 68, showing 54%. It is followed by the second cycle which shows the score average of 80 with 75%. Furthermore, the third cycle releases the score average of 81 with 79%.
Successful radiation treatment of undertail fibrosarcoma in a Major Mitchell’s cockatoo (Lophochroa leadbeateri)
Authors: Hinkle Daria , Eshar David , Ambar Neta , Schneider Sarah , Azuma Chieko 
Published: March 2022

Abstract

CASE DESCRIPTION
A male Major Mitchell’s cockatoo (Lophochroa leadbeateri) of unknown age presented with an ulcerated mass on the ventral tail caudodorsal to the cloaca.

CLINICAL FINDINGS
An impression smear of the mass showed spindle cell atypia. Multiple biopsies were submitted for histopathology with inconclusive results. A CT scan revealed a soft tissue mass causing compression of the cloacal lumen. The patient underwent surgical debulking, and a core of the mass was submitted again for histopathology, which reported it as fibrosarcoma.

TREATMENT AND OUTCOME
Under repeated general isoflurane gas anesthesia, the patient received a course of definitive radiation therapy totaling 60 Gy and divided in 3 Gy X 20 fractions. By treatment completion, the lesion had decreased in size with necrotic debris on the surface. Surrounding tissues appeared healthy and no adverse effects were observed. As of 1.5 years post-treatment, the mass appears completely healed with no signs of reoccurrence.

CLINICAL RELEVANCE
This case suggests that radiation therapy with this protocol could be an effective treatment option for fibrosarcoma in avian species.
Generalized Anxiety Disorder: Diagnosis and Treatment
Authors: Soen Cindy Claudia , Hardjasasmita Irena Monica , Ulitua Aretha Ever 
Published: March 2022

Generalized Anxiety Disorder or GAD is the most common psychological disorder that is characterized by excessive anxiety and worry (expectations of restlessness) where the symptoms last for six months. The ultimate aims of this research are to explain GAD with its three approaches such as humanistic, psychoanalytic and cognitive based on literature review and research evidence and identify the assessment and treatment for GAD. Treatment for GAD consists of various forms of psychotherapy for instance Cognitive Behavior Therapy (CBT) and Acceptance Based Group Behavioral Therapy (ABBT). We believe that the result of this study can be used as reference to find more about generalized anxiety disorder and come up with specific treatment that is more effective.
Sikap Dokter Puskesmas di Jakarta Terhadap Pasien dengan Adiksi Zat Psikoaktif
Authors: Pranoto Fajar 
Published: March 2022

Latar Belakang: Peningkatan penggunaan zat psikoaktif masihmenjadi masalah kesehatan masyarakat di Indonesia. Dokter puskesmas memiliki peranan penting untuk deteksi dini dan melakukan promosi kesehatan. Beberapa penelitian justru menemukan dokter cenderung bersikap negatif terhadap pasien dengan adiksi zat psikoaktif. Sikap negatif dari para dokter dapat menyebabkan layanan kesehatan yang diberikan menjadi tidak optimal. Tujuan dari penelitian ini adalah untuk mengevaluasi sikap dokter puskesmas terhadap pasien dengan adiksi zat psikoaktif.
Metode: Desain penelitian ini adalah studi deskriptif dengan metode potong lintang. Sampel penelitian adalah dokter puskesmas yang praktik di unit-unit pelayanan kesehatan di seluruh puskesmas wilayah DKI Jakarta. Data sikap dokter diambil menggunakan kuesioner Medical Condition Regard Scale. Data penelitian yang diperoleh dianalisis menggunakan uji deskriptif.
Hasil: Sebanyak 569 dokter berpartisipasi dalam penelitian ini. Sebagian besar dari mereka adalah perempuan berusia 25-35 tahun dengan pengalaman bekerja kurang dari lima tahun. Hasil dari penelitian ini menunjukkan 307 dokter puskesmas memiliki sikap negatif (54%), sedangkan 262 dokter memiliki sikap positif (46%).
Kesimpulan: Dokter puskesmas di wilayah DKI Jakarta cenderung memiliki sikap yang negatif terhadap pasien dengan adiksi zat psikoaktif. Penelitian-penelitian lebih lanjut perlu dilakukan untuk menganalisis faktor-faktor yang memengaruhi sikap dokter tersebut.
Kata Kunci: sikap, dokter, puskesmas, Medical Condition Regard Scale
Tatalaksana Ventilasi Pada Pasien Coronavirus Disease 2019 (COVID-19)
Authors: Umar Tungki Pratama 
Published: March 2022

Pendahuluan: Penyakit Coronavirus 2019 (COVID-19) merupakan infeksi saluran pernafasan yang telah menjadi pandemi global. Sekitar 5% dari seluruh penderita penyakit ini memerlukan unit perawatan intensif, dengan Acute Respiratory Distress Syndrome (ARDS) sebagai salah satu komplikasi utama dengan rasio kematian mencapai 94%. COVID-19 yang menyebabkan gangguan terutama pada sistem pernafasan memerlukan tatalaksana yang adekuat, khususnya dalam ventilasi atau oksigenasi untuk mengurangi risiko kerusakan multi organ. Penulis membahas topik tersebut pada tinjauan pustaka ini.
Hasil: Tatalaksana ventilasi pada pasien COVID-19 harus memegang prinsip Safe (untuk petugas dan pasien), Accurate (mencegah teknik yang tidak biasa), serta Swift (cepat). Manajemen jalan nafas pada pasien COVID-19 memiliki risiko yang sangat tinggi karena besarnya peluang aerosolisasi yang terjadi. Pemberian ventilasi (oksigenasi) pada pasien dengan COVID-19 memiliki banyak pilihan, mulai dari nasal cannula, face mask, rebreathing masks, Venturi Mask, Non-rebreathing Mask (NRM), High Flow Nasal Cannula, Non Invasive Ventilation (NIV), hingga intubasi dengan ventilasi mekanik. Mengenai intubasi, hingga saat ini tidak terdapat protokol khusus, terutama terkait silang pendapat tentang early atau late intubation.
Simpulan: Pemilihan teknik pemberian oksigen maupun keputusan intubasi sangat bergantung pada kebijaksanaan dari dokter anestesi yang hadir dan menilai sesuai dengan kebutuhan individu dan status klinis pasien.
UJI SINERGITAS ANTIFUNGAL FLUCONAZOLE DENGAN MINYAK ATSIRI CYMBOPOGON CITRATUS TERHADAP JAMUR CANDIDA ALBICANS
Authors: Sihole Sharon Claudia Ethelyn , Kurniawan Sandy Vitria 
Published: March 2022

ABSTRAK
Pendahuluan: Candida albicans merupakan flora normal yang dapat ditemukan di dalam tubuh, jika berada pada jumlah diatas normal, C. albicans dapat menyebabkan penyakit kandidiasis. Penyakit kandidiasis dapat diobati dengan fluconazole, tetapi angka resistensi fluconazole semakin meningkat. Maka diperlukan alternatif lain seperti tanaman herbal. Cymbopogon citratus merupakan tanaman yang terbukti memiliki efek antifungal. Penelitian ini dilakukan untuk melihat apakah fluconazole dengan minyak atsiri C. citratus dapat bekerja sinergis menghambat pertumbuhan C. albicans.
Metode: Desain pada penelitian ini menggunakan studi eksperimental yang dilakukan secara in vitro. C. citratus diekstraksi dengan metode distilasi air. Metode uji yang dilakukan adalah dengan metode difusi cakram pada agar Mueller-Hinton dengan glukosa 2% dan methylene blue. Konsentrasi minyak atsiri C. citratus yang dipakai adalah 2,5%, 5%, 10%, dan 20% dilarutkan dengan tween.
Hasil: Konsentrasi minimal minyak atsiri C. citratus menghasilkan adanya hambatan pada pertumbuhan C. albicans pada konsentrasi 10% dengan rata-rata diameter zona inhibisi 10 mm. Konsentrasi minimal kombinasi fluconazole dengan C. citratus menghambat pertumbuhan C. albicans pada konsentrasi 2,5% dengan rata-rata diameter zona inhibisi 21,3333 mm. Kombinasi fluconazole dengan minyak atsiri C. citratus memiliki diameter zona inhibisi lebih besar dibandingkan dengan zona inhibisi minyak atsiri ditambah dengan zona inhibisi fluconazole sehingga fluconazole dengan minyak atsiri C. citratus teruji sinergis.
Simpulan: Terdapat sinergitas antifungal fluconazole dan minyak atsiri C. citratus terhadap pertumbuhan jamur C. albicans.
Kata Kunci: Candida albicans, Cymbopogon citratus, Fluconazole, Sinergitas
Body Mass Index Affect Extracellular Mass/Body Cell Mass Ratio The Most
Authors: Antonia Myra 
Published: March 2022

ABSTRACT
Background: Extracellular mass/body cell mass (ECM/BCM) ratio is a independent predictor mortality in nutritional status and certain chronic disease. ECM/BCM ratio is influenced by various factors such as muscle mass, blood cells, bone mass, tendons, total body water, and certain chronic diseases.
Objective: Determine factors associated with elderly ECM/BCM ratio in Jakarta nursing home.
Methods: This observational cross-sectional study was conducted in four nursing home in Jakarta. Nutritional status measured with Mini Nutritional Assessment (MNA) score, Body Mass Index (BMI), Waist Circumference (WC), Mid-Arm Circumference (MAC), and calf circumference (CC) using measurement. ECM/BCM ratio is measured using Maltron Bioscan 916, Pearson correlation and Kendall's Tau B were used for bivariate analysis. Simple linear regression was used for multivariate analysis.
Results: A total of 74 subjects were recruited (mean age 72.12 years, 71.6% women). Body mass index (p<0.05), WC (p<0.05), and CC (p<0.05) were negatively associated with ECM/BCM ratio, while MNA score (p<0.05) and age (p<0.05) were positively associated with ECM/BCM ratio. There wasn't any significant difference in TBW between male and female elderly. In the multivariate linear regression analysis, BMI was negatively associated with ECM/BCM ratio (p<0.05).
Conclusions: Significant relationship were found independently between MNA score, BMI, WC,MAC, and age with ECM/BCM ratio. Body mass index is the main factor associated with ECM/BCM ratio in the elderly in Jakarta nursing homes. Our findings suggest that elderly with lower BMI have higher ECM/BCM ratio.
EVALUATION OF QUANTITATIVE AND QUALITATIVE USAGE STATUS OF AGRICULTURAL LANDS OF THE OMSK REGION
Authors: Долматова О.Н. , Омельянюк Л.В. , Цыплёнкова И.В. , Курячая Е.А. 
Published: March 2022

Омская область обладает огромными площадями земельных ресурсов, являющимися залогом продовольственной безопасности населения. В статье проанализирована динамика изменения площадей категории земель сельскохозяйственного назначения, сельскохозяйственных угодий и посевных площадей сельскохозяйственных культур Омской области за период 1990–2017 гг., а также выполнена оценка их количественного и качественного состояния.
Omsk region possesses vast areas of land, are guarantee of food security of the population. The article analyzes the dynamics of areas category of agricultural land, agricultural land and sown areas with agricultural crops, Omsk region for the period 1990–2017, and also evaluated their quantitative and qualitative condition.
« WOW » Un programme pour développer la compétence d’émerveillement et aider les adolescents à trouver un sens à leur vie en nature.
Authors: Lépée Morgane 
Published: March 2022

Dans notre monde moderne, les adolescents sont confrontés à un manque de sens et à une déconnexion croissante à la nature. Ces phénomènes peuvent conduire à la dépression et à des comportements suicidaires. La connexion à la nature et la recherche de sens sont des facteurs importants de bien-être. Les progrès de la science de l’émerveillement ont permis de placer cette émotion comme médiateur entre la nature et le sens. L’émerveillement, en tant qu'émotion d’auto-transcendance suscitée principalement dans la nature, a le potentiel de transformer la vie des adolescents en apportant du sens à leur existance. Dans le contexte de la psychologie positive, l’émerveillement est une compétence de vie qui, par la formation et la pratique, peut aider les adolescents à surmonter les difficultés de la vie quotidienne et améliorer leur bien-être.L'objectif de ce projet "Cortica Journal Club" est d'exploiter les résultats des recherches existantes sur l’émerveillement et l'adolescence pour créer un programme de formation visant à développer cette compétence de vie chez les adolescents. Conçu sur une durée de 26 jours, le programme est un outil d'auto-assistance pour développer la connexion à la nature, l'aptitude à l’émerveillement, et accroître le sens et le bien-être. En développant et en cultivant cette capacité d’émerveillement, les adolescents pourront obtenir une protection contre les maladies mentales et un chemin vers le bien-être
Mots clés : émerveillement, cerveau, adolescence, nature, psychologie positive.

Abstract
In our modern world, teenagers face a lack of meaning and a growing disconnection from nature. These phenomena can lead to depression and suicidal behavior. The connection to nature and the search for meaning are important factors of well-being. Advances in the science of wonder have made it possible to place this emotion as a mediator between nature and meaning. Wonder, as an emotion of self-transcendence elicited primarily in nature, has the potential to transform the lives of adolescents by bringing meaning to their existence. In the context of positive psychology, wonder is a life skill that, through training and practice, can help adolescents overcome the difficulties of everyday life and improve their well-being. The goal of this « Cortica Journal Club » is to leverage existing research findings on wonderment and adolescence to create a training program aimed at developing this life skill in adolescents. Designed over a period of 26 days, the program is a self-help tool to develop connection to nature, the ability to wonder, and increase meaning and well-being. By developing and cultivating this capacity for wonder, teens can gain protection from mental illness and a path to well-being
Keywords: wonder, brain, adolescence, nature, positive psychology.
TUMPANGSARI TANAMAAN PORANG (Amorphophallus muelleri Blume) DENGAN POHON KETIMUNAN (Gyrinops versteegii) DI HKM DESA PUSUK LESTARI, KABUPATEN LOMBOK BARAT
Authors: Mulyaningsih Tri , Muspiah Aida , Hidayati Ernin , Faturrahman Faturrahman , Hidayat Wiwin 
Published: March 2022

Tanaman porang (A. muelleri) dapat memproduksi umbi yang mengandung glukomanan hingga 54% (yang bermanfaat bagi kesehatan dan bahan industri. Tanaman ini dapat tumbuh dengan baik di bawah tegakan, sehingga dapat ditumpangsarikan dengan pohon apa saja termasuk pohon gaharu yang dikonservasi secara ex situ di HKM Pusuk Lestari Lombok Barat. Tujuan kegiatan pengabdian ini adalah memberi pengetahuan tentang budidaya tumpangsari tanaman porang dengan pohon G. versteegii yang ditanam satu tahun yang lalu untuk konservasi ex-situ di kawasan HKm Desa Pusuk Lastari, Batu Layar Lombok Barat, dan memberikan pelatihan serta praktek penanaman bibit porang dikawasan HKm dengan sistem agroforestry, untuk meningkatkan pendapatan dan kesejateraan bagi para pemangku HKm di Desa Pusuk Lestari. Hasil kegiatan pengabdian ini adalah telah terlaksana kegiatan pelatihan tentang budidaya porang dengan metode tumpang sari dengan pohon G. versteegii, mulai dari pemilihan bibit berkualitas, pencarian distributor penjual dan pemesanan bibit porang hingga, penanganan bibit sebelum ditanam. Sedangkan praktek persiapan penanaman, seperti penyiangan lahan, penggemburan tanah, pembuatan gulutan tanah, membuat jarak tanam dan penanaman bibit porang dilakukan secara ditumpangsarikan dengan pohon gaharu jenis G. versteegii di areal HKM Pusuk Lestari Lombok Barat.