bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacuum infusion as a novel method to determine wood permeability
Authors: Acosta Andrey Pereira , Barbosa Kelvin Techera , Silva Amanda Albertin Xavier da , Gatto Darci Alberto , Delucis Rafael de Avila , Amico Sandro Campos 
Published: August 2022

Abstract
This study aims to propose a novel method, vacuum infusion process, to measure the longitudinal permeability of wood. The vacuum infusion method uses a vacuum bag sealed over the fibrous material, with a vacuum inlet and a vacuum outlet. It can be performed on top of any flat surface, and its process is relatively swift. Six different woods (Pinus elliottii, Araucaria angustifolia, Ochroma pyramidale, Cedrela fissilis, Tectona grandis, and Eucalyptus grandis) and three different fluids (water, soybean oil, and furfuryl alcohol) were selected for the study. After preliminary evaluations of morphology, chemical characteristics, density, porosity, contact angle and capillary pressure, three woods and two fluids were selected for the actual permeability measurements. The highest permeability was obtained for the Ochroma pyramidale wood, being 0.45–7.49×10–11 m2. This wood was 58–88% and 18–62% more permeable than the Pinus elliottii and Eucalyptus grandis woods, respectively. The fluid was found to have some influence on the experiment and therefore must be carefully selected. The difference in permeability of the woods was attributed to morphological characteristics, especially the presence of axial vessels, which are 60% larger for Ochroma pyramidale wood compared to Eucalyptus grandis wood, while Pinus elliottii has no vessels. The amount of voids in all woods, nevertheless, was similar, as well as the evaluated chemical characteristics and structural anatomical elements (tracheids and/or fibers). In all, the determination of apparent permeability using the vacuum infusion process is practical and with good accuracy, yielding results similar to those from other methods in the literature.
Genome-based typing reveals rare events of patient contamination with Pseudomonas aeruginosa from other patients and sink traps in a medical intensive care unit
Authors: Couchoud Charlotte , Bertrand Xavier , Bourgeon Marilou , Piton Gaël , Valot Benoit , Hocquet Didier 
Published: August 2022

Abstract
Background
We used genome-based typing data with the aim of identifying the routes of acquisition of Pseudomonas aeruginosa (PA) by patients hospitalized in a medical intensive care unit (MICU) over a long period in a non-epidemic context.
Methods
This monocentric prospective study took place over 10 months in 2019 in a 15-bed MICU that applies standard precautions of hygiene. Lockable sink traps installed at all water points of use were bleach disinfected twice a week. We sampled all sink traps weekly to collect 404 PA environmental isolates and collected all PA isolates (n = 115) colonizing or infecting patients (n = 65). All isolates had their phenotypic resistance profile determined and their genome sequenced, from which we identified resistance determinants and assessed the population structure of the collection at the nucleotide level to identify events of PA transmission.
Results
All sink traps were positive for PA, each sink trap being colonized for several months by one or more clones. The combination of genomic and spatiotemporal data identified one potential event of PA transmission from a sink trap to a patient (1/65, 1.5%) and six events of patient cross-transmission, leading to the contamination of five patients (5/65, 7.7%). All transmitted isolates were fully susceptible to β-lactams and aminoglycosides.
Conclusions
Genome-based typing revealed the contamination of patients by PA originating from sink traps to be infrequent (1.5%) in a MICU with sink trap-bleaching measures, and that only 7.7% of the patients acquired PA originating from another patient.
Void space and scaffold analysis of packed particles: applications in granular biomaterials
Authors: Riley Lindsay , Cheng Peter , Segura Tatiana 
Published: August 2022

Abstract
We have developed a tool for analyzing packed particles in response to the growing popularity of granular biomaterials. Granular hydrogels, including microporous annealed particle (MAP) scaffolds, are a class of material used for therapeutic applications due to their unique properties, including micro-porosity between particles. The microarchitecture of granular materials is challenging to study, which leads many in the field to report the unreliable metric of void volume fraction and/or 2D-slice approximations to ‘pore size’ as the only characterizations of void space. In response, we have created LOVAMAP, a custom software that combines techniques from computational geometry and graph theory to segment the void space into 3-D pores, which are the natural pockets of open space. LOVAMAP’s 44 scaffold features provide the user with a quantitative profile that describes both the interior and entrances of the scaffold. Our visually-rich outputs address topics like void space size, shape, connectivity, paths, isotropy/anisotropy, ligand availability, and infiltration/migration restrictions. Using LOVAMAP, we have studied 60 different types of granular scaffolds, including real MAP scaffolds with corresponding cell data. We use higher dimensional analysis to show that output data from our software can be used to classify types of 3-D pores, as well as characterize entire scaffolds by generating a numeric ‘fingerprint.’ In conjunction with cell data, LOVAMAP reveals relationships between neurosphere formation and scaffold void space geometry. LOVAMAP is an enabling technology with broad applications for granular biomaterial research and for all fields that study granular material.
A Randomized Clinical Trial Evaluating Three Low-volume Preparations for Colonoscopy in Outpatients With Inflammatory Bowel Disease: The Eii-prep Trial.
Authors: García Jose Luis Rueda , Ferrer Cristina Suárez , Martín-Arranz Eduardo , Sánchez-Azofra María , Cordón Joaquín Poza , García-Ramírez Laura , Noci Jesús , Vergés Tamara , Miguel Paula Blanco San , Martín-Arranz María Dolores 
Published: August 2022

Abstract

BACKGROUND: Bowel preparation is crucial for colonoscopies in patients with Inflammatory Bowel Disease (IBD). However, data regarding cleansing solutions in this setting are scarce. AIMS: Our aim was to compare efficacy, safety, and tolerability of three different low-volume preparations in patients with IBD.METHODS: Single-center, randomized, prescriber- and colonoscopist-blinded clinical trial. IBD outpatients undergoing colonoscopy were randomized 1:1:1 to receive 1 Liter-polyethylene glycol-ascorbate (1L-PEG), 2 Liters-PEG or sodium picosulfate (SP). Primary endpoint was efficacy in terms of percentage of quality cleansing assessed via the Boston Bowel Preparation Scale (BBPS >=6 with segments >=2). Secondary endpoints were efficacy in terms of total high quality cleansing (BBPS 8 or 9), high quality segmental BBPS (>=2) and patients’ tolerability, symptoms, and satisfaction, assessed by questionnaires before and after colonoscopy. Safety was monitored by adverse event reporting, laboratory evaluation at colonoscopy and telephonic follow-up.RESULTS: 92 patients were included (33 1L-PEG, 28 2L-PEG and 31 SP). No significant differences between preparations were observed in quality or high-quality total BBPS or high-quality segmental BBPS. Complete intake of the solution was higher for SP (p=0,006) and lower for 1L-PEG (p=0,02). Clinically irrelevant hyponatremia was higher in the SP group (p<0,0001). SP instructions were easier to understand from the patient’s point of view (p=0,01). Willingness to retake was higher with SP (p<0,0001) and less for 1L-PEG (p<0,0001). No serious adverse events were reported.CONCLUSIONS: We observed no differences between PEG-based bowel preparations and SP regarding efficacy in patients with IBD. Complete intake was higher for SP and lower for 1L-PEG. SP and 2L-PEG instructions were better understood and graded, and SP was more likely to be retaken. Willingness to retake was lower for 1L-PEG. No serious adverse events were reported.
Performance Enhancement of Multi channel Multi Beam FSO Communication link with the application of Reed Solomon codes
Authors: Kumar Suresh , Sharma Deepak 
Published: August 2022

Abstract
The rise in user’s requirement for high speed applications and services has necessitated the requirement of a communication link that can provide the data rate comparable to optical fiber. Free Space Optical (FSO) Communicationis being admired means of communication from past few years. To achieve seamless and error free transmission at high speed for heterogeneous multimedia applicationsat desired bit rates, novel advancements in optical communication technology are being explored along with FSO. However, several constraints such as atmospheric turbulence, uneven terrain, dynamic climatic conditions cause several nonlinearities which limits the connectivity. In this work, a multi channel multi beam FSO communication system by incorporating Reed Solomon (RS) Codes has been proposed at 30Gbps. The Modified Gamma-Gamma model is beingapplied for channel turbulences. The application of forward error correction (FEC) coding in the designed system offers ease of error detection and correction with improved performance at higher data rate for implementation over longer link lengths.The system performance has been evaluated for (i) Number of errors corrected, (ii) Bit Error Rate (BER), (iii)Received power, (iv) Geometric path losses and (v) SNR. At an acceptable BER of 10− 9, the RS (255, 127, 129) encoded four channel four beam FSO communication link to be effectively implemented for a distance of 3500m with − 32.5dBmreceived low optical power and 25 dB SNR.
WITHDRAWN: Preparation of nitrogen-doped nZVI/biochar by chemical modification and its activated peroxymonosulfate to degrade Florfenicol
Authors: Huang Wen , Zhang Xueping , Tang Yaxin , Zheng Shijie , Zhang Jianqiang 
Published: August 2022

Abstract
In this study, corn cobs were modified in low concentration of H2O2, grafted with different concentrations of diethylenetriamine (DETA) and dissolved in FeCl3·6H2O solution to produce iron-nitrogen co-doped corn cob precursors (DETA-OCs), and then the new nitrogen-doped nZVI-biochar (nZVI/N30-CC, nZVI/N10-OC, nZVI/N20-OC and nZVI/N30-OC) were prepared bypyrolysis of the precursors at 850℃ by carbothermal reduction. The results showed that DETA was grafted onto modified corn cob (OC) by Schiff base reaction and contained more iron ions on the precursor by chelation reaction. Compared to the unmodified nZVI/N30-CC, the modified nZVI/N30-OC had a higher specific surface area, porous and defective structure due to the higher Fe and N content, as well as an increased content of active components such as nZVI crystals, Fe-Nx and graphitic nitrogen on the biochar. When nZVI/N30-OC and PMS were present at the same time, FF was completely degraded within 30 min, and it still had good activation properties after 4 reapplications. The radical quenching and electron spin resonance analysis showed that the nZVI/N30-OC/PMS system could effectively produce SO4 − ∙, ·OH, O2-g and 1O2 , with 1O2 playing a dominant role in the degradation of FF. While the results of X-ray photoelectron spectroscopy studies showed that oxygen-containing functional groups (C-OH, COOH), graphitic nitrogen, and Fe-Nx on biochar produced 1O2 by activating PMS through the non-radical pathway, while the radical pathway had nZVI as the main active site. AC impedance spectroscopy (EIS) and linear scanning voltammetry (LSV) further confirmed the presence of non-radical pathways in the nZVI/N30-OC/PMS system and identified the electron transfer process. In summary, this study prepared high Fe and N content co-doped biochar through green modification, which provided a new idea for heteroatom/transition metal co-doped carbon materials, as well as a new option for activating PMS to degrade organic waste.
Spontaneous Radiative Cooling to Enhance the Operational Stability of Perovskite Solar Cells via a Black-body-like Full Carbon Electrode
Authors: Yu Bingcheng , Shi Jiangjian , Li Yiming , Tan Shan , Cui Yuqi , Meng Fanqi , Wu Huijue , Luo Yanhong , Li Dongmei , Meng Qingbo 
Published: August 2022

Abstract
Operational stability of perovskite solar cells is remarkably influenced by the device temperature, therefore, decreasing the interior temperature of the device is one of the most effective approaches to prolong the service life. Herein, we introduce the spontaneous radiative cooling effect into the perovskite solar cell and amplify this effect via functional structure design of a full-carbon electrode (F-CE). Firstly, by the aid of interfacial engineering, >19% and >23% power conversion efficiencies of F-CE based inorganic CsPbI3 and hybrid perovskite solar cells have been achieved, respectively, both of which are the highest reported efficiencies based on carbon electrode and are comparative to the results for metal electrodes. Highly efficient thermal radiation of this F-CE can reduce the temperature of the operating cell by about 10°C. Compared with the conventional metal electrode-based control cells, the operational stability of the above two types of cells have been significantly improved due to this cooling effect. Especially, the CsPbI3 PSCs exhibited no efficiency degradation after 2000 hours continuous operational tracking.One-Sentence Summary: Thermal radiative cooling effect of full-carbon electrode enhances operational stability of the perovskite solar cells.
Trimming nano delivery at the cell side by tuning ARF6 GTPases to the GTP-bound form
Authors: Song Siyang , Guo Xiangfu , Zhang Runyu , Yan Zhicheng , Chen Qing , Song Yang , Wu Peiyao , Wang Chunling , Cheng Yuxi , Yuan Lan , Zhang Hua , Dai Wenbing , Wang Xueqing , He Bing , Zhang Qiang 
Published: August 2022

Abstract
Intracellular delivery crossing the endomembrane barrier is the “last mile to target” for nano delivery systems carrying biomacromolecules, including genetic medicines. Nevertheless, a mass of nanomedicines is currently restricted by their equivocal safety and delivery efficiency. Here, we trimmed nano delivery at the cell perspective and established a general strategy independent of nanomaterials. Such a policy broadly facilitates the intracellular delivery of all kinds of tested nanomedicines, subtly by inducing ARF6 GTPases to their overactivated GTP-bound state. We discovered that ARF6, one member of ARF subfamily in small GTPases, regulated intracellular vesicle transport and lipid metabolism through GTP/GDP conversion. More importantly, we demonstrated that ARF6 biased to GTP-bound form induced GTPase overactivation, promoting endocytosis and reducing exocytosis of cargoes, including transferrin proteins and eleven types of nanogranules. This universal effect was mechanistically derived from forming a particular category of hybrid endosomes triggered by overactivated ARF6 via regulating cholesterol-associated vesicles and lipid raft/caveolae pathways. Cargoes were steadily and slowly delivered to the cytoplasm due to the mild microenvironment in hybrid endosomes. Based on these findings, we identified that QS11, a safe small molecule inhibitor of ARF GTPase-activating proteins, enhanced the antitumor efficacy of siEGFR-loaded nanoparticles by inducing ARF6 overactivation. In sum, it demonstrates that the tactics of tuning ARF6 GTPases to GTP-bound form will widely benefit cellular nano delivery.
Gender Consequences of Covid-19 with Equal Bequest Laws
Authors: Tan Na , Farmer Amy , Horowitz ANdrew 
Published: August 2022

Abstract
The Covid-19 pandemic has had profound distributional consequences in many dimensions. One important dimension that has received relatively little attention is the impact on intergenerational transfers (inter-vivos and bequests). We explore the gender distribution consequences of a mortality probability shock in the context of equal-inheritance division laws – which affect bequest distribution for most of the global population. We first develop a theoretical model of likely responses to the mortality shock and then simulate the model to explore magnitudes and obtain predictions for some complex interactions that are not tractable theoretically. We find that in the context of equal-division laws and son-bias, increased death probability due to Covid-19 will shift resources to inter-vivos transfers to sons, at the expense of daughters. The simulations reveal an unexpected non-monotonicity in the ratio of total sons to daughters total transfers as death probabilities increase.JEL Codes: D1, D13, D15, D31, D64, I1, I19, J14, J16, K1, K36, K38
Regional brain glucose metabolism is differentially affected by ketogenic diet: A human semiquantitative positron emission tomography
Authors: Horowitz tatiana , Doche Emilie , Phlip Mary , Cammilleri Serge , Suissa Laurent , GUEDJ Eric 
Published: August 2022

Abstract
Purpose
Ketogenic diet (KD) is recommended to avoid intense [18F]FDG myocardial physiologic uptake in PET imaging. Neuroprotective and anti-seizure effects of KD have been suggested, but their mechanisms remain to be elucidated. This [18F]FDG PET study aims to evaluate the effect of KD on glucose brain metabolism.
Method
Subjects who underwent KD prior to whole-body and brain [18F]FDG PET in our department for suspected endocarditis were retrospectively included. Myocardial glucose suppression (MGS) on whole-body PET was analysed. The main exclusion criteria were brain abnormalities. Thirty-four subjects with MGS were considered the KD population, and 14 subjects without MGS were considered a KD failure. Brain SUVmax of these groups was compared. Second, the KD population (n = 34, mean age: 61.8 ± 17.2 years) was compared to a control group of 27 healthy subjects fasting for at least 6 h (mean age of 62.4 ± 10.9 years). A semiquantitative voxel-based intergroup statistical analysis was conducted using SPM.
Results
A 20% lower brain SUVmax was found in subjects under KD with MGS in comparison to those without MGS, p = 0.02. Whole-brain voxel-based intergroup analysis revealed that patients under KD had relative hypermetabolism of limbic regions including medial temporal cortices and cerebellum lobes and relative hypometabolism of bilateral posterior regions (occipito-parietal).
Conclusion
KD globally reduces brain glucose metabolism but with regional differences. These results have a clinical implication, since the realization of a KD could lead to misinterpretation of these regions, and a pathophysiological perspective as it could help understand underlying neurological effects of KD through possible decrease of oxidative stress in posterior regions, and functional compensation in the limbic regions.
Differential gene expression analysis unravels key genes associated with breast cancer proliferation
Authors: Ibrahim Asmaa , Saleem Mansour Al , Toss Michael , Miligy Islam , Green Andrew R , Rakha Emad 
Published: August 2022

Abstract
Background: Improved understanding of breast cancer (BC) complex molecular pathways is required to predict prognosis and develop new therapeutic strategies. The purpose of this study is to apply an integrated approach that combine both clinical and bioinformatic data to reveal novel regulators of proliferation.Methods and Results: Whole slide images generated from haematoxylin and eosin-stained sections of The Cancer Genome Atlas (TCGA) BC database alongside their transcriptomic and clinical data, were used to identify differentially expressed genes (DEG) associated with cell division determined using mitotic scores. DEGs enriched in the cell cycle pathway were utilised to predict protein-protein interaction (PPI) network. Ten hub genes (ORC6, SMC1B, CDKN2A, CDC25B, E2F1, E2F2, SKP2, ORC1, PTTG1, CDC25A) were identified using CytoHubba, a plugin of Cytoscape. The results were validated using the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) database. High expression of the ten hub genes was significantly correlated with worse survival. ORC 6, SKP2, and CDC25B were predictors of survival independent of mitotic score or Ki67. ORC6 and SKP2 protein expression level in tumor tissue were significantly higher than in normal breast tissue.Conclusions: ORC6, SKP2 and CDC25B play important role in BC proliferation and surpassed both Ki67 and mitotic score in multivariate analysis, thus can serve as potential prognostic markers and therapeutic targets.
Speech-in-noise perception in school-age cochlear implants users compared to their peers with normal hearing: evidence of a critical condition
Authors: Oryadi-Zanjani Mohammad Majid 
Published: August 2022

Abstract
Background: Although cochlear implants (CIs) is the state-of-the-art therapy for individuals with hearing impairment to process the acoustic-phonetic cues of speech during the sensitive period of spoken language development and to access optimal auditory performance, previous research findings demonstrated that the users have essential challenges with speech recognition in the presence of background noise. Therefore, the aim of this study was to determine speech-in-noise (SiN) perception in Persian school-age CIs/hearing aids (HAs) users compared to their peers with normal hearing (NH). Methods: The research was administered as a cross-sectional study. Speech-in-noise performance in thirty-three school-age children with hearing loss (19 unilateral CIs users and 14 bilateral HAs users) was compared to twenty school-age children with normal hearing by using the Persian Lexical Neighborhood Tests (PLNTs) include: Persian Monosyllabic Lexical Neighborhood Test (PMLNT)-easy, PMLNT-hard, Persian Disyllabic Lexical Neighborhood Test (PDLNT)-easy, and PDLNT -hard. To make sure that floor or ceiling effects would not effect on the children’s performance, the PLNTs were performed by sound field at different levels of signal to noise ratio (SNR). Results: The SiN performance on all four the subscales of the PLNTs was significantly poorer in Persian school-age CIs/HAs users than their peers with NH for all stepwise increases in the SNR (P < 0.001).Conclusions: The Persian school-age CIs users experience a critical condition related to listening spectrally degraded speech in noisy environments such as home, school, and classroom due to SiN perception insufficiency. Accordingly, it can be concluded that they are potentially at-risk of literacy difficulties. Therefore, it is suggested that SiN perception in school-age CIs users be systematically assessed and monitored through valid tests in order to managing their listening problems in the situations with background noise.