bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting Breastfeeding in Complex Pediatric Otolaryngology Dyads: Clinical Pathway With Illustrative Case Series
Authors: Graham M. Elise 
Published: December 2022

Objectives: The benefits of breastfeeding are well established, yet complex infants are less frequently supported to feed direct or pumped breastmilk. This article aims to provide an algorithm to support complex infants in meeting breastfeeding goals. Methods: Two cases are presented to illustrate the breastfeeding support pathway. Each involves early identification of motivated caregivers, consultation of allied health, and assessment of swallowing safety with modification of position or route as appropriate. Results: Two infants presented herein successfully continued to receive breastmilk despite airway complexity—1 with oral aversion secondary to prolonged nil per os period in the setting of tracheoesophageal fistula, and 1 with a tracheostomy secondary to subglottic stenosis. Conclusions: It is both possible and imperative to support complex infants in continuing to breastfeed, either directly or via the safest possible route, for the benefits to both members of the dyad.
Energy-driven damage evolution and instability in fissure-cavity-contained granite induced by freeze-thaw and multistage increasing-amplitude cyclic (F-T-MSIAC) loads
Authors: Wang Yu , Han Jianqiang , Xia Yingjie , Zhang Bo 
Published: December 2022

Rock damage and fracture is energy-driven, the energy conversion characteristics for the pre-flawed rock under static or fatigue loading conditions have been well widely studied. However, energy mechanism of rock containing fissures and hollow hole exposed to coupled freeze-thaw and cyclic loads is not well understood. In this work, damage and fracture evolution of pre-flawed hollow-cylinder granite specimens induced by freeze-thaw and multistage increasing-amplitude cyclic (F-T-MSIAC) loads were investigated using energy analysis. Testing results show that the volumetric deformation of rock is affected by the previous freeze-thaw cycles. Rock volumetric deformation decreases with increasing freeze-thaw cycle. The elastic strain energy and dissipated strain energy both decreases with increasing freeze-thaw cycles. When rocks undergo relatively small freeze-thaw cycles, a large amount of energy is consumed to drive crack propagation and cavity collapse. A coupling damage evolution model considering the freezing-thaw and mechanical damage was proposed. The model fits well to the two-stage and three-stage damage accumulation pattern. Two-dimensional CT images reveal different fracture network morphology and the effect of freeze-thaw weathering on crack coalescence. The results show that rock fracture is easy to occur under high freeze-thaw cycles, and less energy is required to communicate the fissures and hollow hole.
Similarities in the histological mouse model of early herpes simplex retinopathy with punctate inner choroidopathy and Ebola virus disease retinopathy
Authors: Steptoe Paul J , Guly Catherine M , Dick Andrew D 
Published: December 2022

Abstract Purpose To highlight similarities between the cross-sectional retinal lesion appearance in a patient with punctate inner choroidopathy (PIC), Ebola virus disease (EVD) retinopathy and the von Szily mouse model of herpes simplex virus type 1 (HSV) retinopathy. Methods Case report and cross-sectional retinal lesion comparison. Results Whilst phenotypically different on colour imaging, a near-identical lesion appearance on optical coherence tomography, characterised by a focal photoreceptor loss and distinctive V-shaped collapse of the overlying retinal layers, was observed in both PIC and EVD retinopathy. This mirrored the early histological appearance of the neuronally transmitted HSV retinopathy in a mouse model. Conclusions Given the occurrence of this phenotypic appearance has been demonstrated in an animal model where the viral pathophysiological mechanism is known, together with its observation in EVD retinopathy with a shared, hypothesised neurotropic retinal pathogenesis, the potential of a common pathophysiology accounting for the appearance in PIC lesions is a possibility which may provide a potential avenue for future research.
Management of patients undergoing cataract surgery: An Italian survey
Authors: Orfeo Vincenzo , Aragona Pasquale , Rossi Scipione , Mastropasqua Leonardo , Alessio Giovanni , Vinciguerra Paolo , Ciprandi Giorgio , Tognetto Daniele 
Published: December 2022

Purpose To investigate the management of patients undergoing cataract surgery in Italy. Setting Italian ocular surgeons, members of the Italian Association of Cataract and Refractive Surgery (AICCER), were invited to participate to this survey. Design Participants had to respond to a questionary including a series of practical questions concerning the management of patients undergoing cataract surgery. Methods A designed questionnaire explored the main issues concerning the practical problems involved in managing patients undergoing cataract surgery. The questionnaire was sent by e-mail and analyzed by descriptive statistics. Results Preoperative prophylaxis was performed by most surgeons. After surgery, several products were used, even simultaneously. Fixed antibiotic-corticosteroid combination (87.2%; 89) and NSAIDs (88.2; 90) were chosen as the most commonly used drug classes. The average duration of prescribed post-surgical therapies was more than two weeks for 52.9% (54) of participants, two weeks for 29.4% (30), and only one week for 5.9% (6). Conclusion This survey confirmed a discrete adherence to the main guidelines but at the same time highlights a discrete inhomogeneity in the use of medications, duration of treatments, and follow-up visits. For this reason, it is appropriate to continue updating and implementing the guidelines and educational pathways. This thought is consistent with the Precision Medicine approach. Every patient should be carefully evaluated to determine the best medication, dosage, and duration. A Personalized Medicine strategy is used on a single patient to optimize treatment clinical efficacy while minimizing side effects.
Association of electronic cigarette use with circulating angiogenic cell levels in healthy young adults: Evidence for chronic systemic injury
Authors: Amraotkar Alok R , Owolabi Ugochukwu S , Malovichko Marina V , Majid Sana , Weisbrod Robert M , Benjamin Emelia J , Fetterman Jessica L , Hirsch Glenn A , Srivastava Sanjay , Poudel Ram , Robertson Rose Marie , Bhatnagar Aruni , Hamburg Naomi M , Keith Rachel J 
Published: December 2022

Background: Circulating angiogenic cells (CACs) are indicative of vascular health and repair capacity; however, their relationship with chronic e-cigarette use is unclear. This study aims to assess the association between e-cigarette use and CAC levels. Methods: We analyzed CAC levels in 324 healthy participants aged 21–45 years from the cross-sectional Cardiovascular Injury due to Tobacco Use study in four groups: never tobacco users ( n = 65), sole e-cigarette users ( n = 19), sole combustible cigarette users ( n = 212), and dual users ( n = 28). A total of 15 CAC subpopulations with four cell surface markers were measured using flow cytometry: CD146 (endothelial), CD34 (stem), CD45 (leukocyte), and AC133 (early progenitor/stem). Generalized linear models with gamma distribution and log-link were generated to assess association between CACs and smoking status. Benjamini-Hochberg were used to adjust p-values for multiple comparisons. Results: The cohort was 47% female, 51% Black/African American, with a mean (± SD) age of 31 ± 7 years. Sole cigarette use was significantly associated with higher levels of two endothelial marker CACs (Q ⩽ 0.05). Dual users had higher levels of four endothelial marker CACs and one early progenitor/stem marker CAC (Q ⩽ 0.05). Sole e-cigarette users had higher levels of one endothelial and one leukocyte marker CAC (Q ⩽ 0.05). Conclusion: Dual use of e-cigarettes and combustible cigarettes was associated with higher levels of endothelial origin CACs, indicative of vascular injury. Sole use of e-cigarettes was associated with higher endothelial and inflammatory CACs, suggesting ongoing systemic injury. Distinct patterns of changes in CAC subpopulations suggest that CACs may be informative biomarkers of changes in vascular health due to tobacco product use.
Design of experiments to compare the reprocessing effect with Fused Deposition Modeling printing parameters on mechanical properties of Polylactic Acid specimens towards circular economy
Authors: Kuclourya Tanay , Monroy Roberto , Ahmad Rafiq 
Published: December 2022

Distributed Recycling via Additive Manufacturing (DRAM) is a closed-loop material reprocessing solution that promotes circular economy. There are several literature gaps related to material properties and recycling cycles at different stages of the DRAM process. With an approach to filling these gaps, a small contribution has been made through this work by comparing the effect of reprocessing cycles (recycling) with the effect of FDM printing parameters such as Raster angle orientation, Infill density and Extrusion Temperature. These four parameters are ranked based on their impact on the tensile properties of Polylactic Acid (PLA) dog bone specimens. The Design of Experiments via Taguchi Analysis is carried out to avoid analysis of a large number of samples. The results show that recycling has the maximum impact on the tensile properties of PLA samples and can reduce the tensile strength by up to 75% in the course of four reprocessing cycles. The specimens had Ultimate Tensile Strength (UTS) values in the range of 20–26 MPa at the first reprocessing cycle which dropped significantly to a range of 7–9 MPa after the fourth reprocessing cycle. Additionally, a novel analysis on time and the number of specimens to be 3D printed at each reprocessing stage has also been conducted to help future researchers manage their printing schedule, especially in the recycling domain.
Volumetry of Hand and Forearm: A 3D Volumetric Approach
Authors: Oezel Lisa , Latz David , Gehrmann Sebastian Viktor , Taday Roman , Windolf Joachim , Schiffner E. 
Published: December 2022

Background: Swelling and edema of the hand and forearm may occur in various traumatic and degenerative diseases. So far, no precise measurement protocol exists. The objective of this study was to evaluate an examination protocol with relevant regions of interest (ROIs) measured by a 3-dimensional (3D) scanner to achieve precise, reproducible, and objective measurements for an optimized detection of volumes of the hand and forearm. Methods: A 3D scan protocol was developed using an Artec, 3D scanner EVA to measure discrete hand volumes of healthy volunteers. Five areas were defined as ROIs, representing volumes of the finger, metacarpus, wrist, hand, and distal forearm. Contralateral limbs were used for volume comparisons and calculation of volume differences. Results: For this study, 12 individuals (58.3% women, 24 hands and forearms) with a mean age of 27.1 ± 3 years were included. Mean volume values for left and right ROIs correlated with each other, with slightly higher volumes for the right upper extremity. Volume differences showed statistically significant results for the finger region (ROI I; P = .009), the metacarpal region (ROI II; P < .001), hand region (ROI IV; P = .001), and forearm region (ROI V; P = .006), with the exception of the wrist region (ROI III; P = .722). Conclusions: Our results demonstrate that this 3D volumetric approach is a reliable and objective tool for measuring volumes and circumferences in hand and forearm. Based on our determined ROIs, further studies are needed to explore the significance for clinical applications.
Validation of three-dimensional printed models of intracranial aneurysms
Authors: Mantilla Daniel E , Ferrara Riccardo , Ortiz Andrés F , Vera Daniela D , Nicoud Franck , Costalat Vincent 
Published: December 2022

Introduction Three-dimensional (3D) printing has evolved for medical applications as it can produce customized 3D models of devices and implants that can improve patient care. In this study, we aimed to validate the geometrical accuracy of the 3D models of intracranial aneurysms printed using Stereolithography 3D printing technology. Materials and methods To compare the unruptured intracranial aneurysm mesh between the five patients and 3D printed models, we opened the DICOM files in the Sim&Size® simulation software, selected the region of interest, and performed the threshold check. We juxtaposed the 3D reconstructions and manually rotated the images to get the same orientation when needed and measured deviations at different nodes of the patient and 3D printed model meshes. Results In the first patient, 80% of the nodes were separated by <0.56 mm and 0.17 mm. In the second patient, the deviations were below 0.17 mm for 80% of the meshes’ nodes. In the next three patients, the deviations were below 0.21, 0.23, and 0.11 mm for 80% of the meshes’ nodes. Finally, the overall deviation was below 0.21 mm for 80% of the mesh nodes of the five aneurysms Conclusions 3D printed models of intracranial aneurysms are accurate, having surfaces that resemble that of patients’ angiographies with an 80% cumulative deviation below 0.21 mm.
The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study
Authors: Muñoz-Vergara Dennis , Schreiber Kristin L. , Langevin Helene , Yeh Gloria Y. , Zhu Yehui , Rist Pamela , Wayne Peter M. 
Published: December 2022

Background There is a knowledge gap in the physiological effects of short-term yoga exercise interventions. Objective To evaluate the feasibility of a randomized controlled trial (RCT) assessing the acute effects of a yoga exercise protocol practiced at 2 intensities (high or moderate) on temporal responses of a battery of systemic circulatory cytokines in healthy yoga-naïve adults. Methods This study was a three-arm, pre-post pilot-RCT employing a single bout of yoga exercise intervention. Groups were high-intensity yoga (HY, n = 10), moderate-intensity yoga (MY, n = 10), and a sedentary, no-intervention control group (CON, n = 10). Blood samples were collected at baseline and post-intervention at 6 timepoints (0-, 30-, 60-, 120-, 180-minutes, and 24-hours post-intervention) and were processed with a pre-defined inflammatory panel of 13 cytokines. Heart rate (HR) was assessed with a Polar H10® device. The PROMIS Pain intensity Questionnaire was used to assess body soreness. Results We demonstrate feasibility of recruitment, randomization, and retention of participants based upon predetermined metrics, including: proportion of eligible to enrolled participants (55%); recruitment period (11-months); participant retention (97%); completion rate for questionnaires (99%); completion of physiological measures (98%); and adherence to the yoga exercise protocol (88%). Cytokine levels over time were heterogeneous within and between groups. Responses of a subset of cytokines were positively correlated with 1 another in high- and moderate-intensity yoga exercise groups but not in the control group. Median values for HR were 91 (IQR: 71–95) in the HY, 95 (IQR: 88–100) in the MY, and 73 (IQR: 72–75) in the CON. Pre-post changes in body soreness after the yoga exercise intervention were most evident in the HY group. Conclusion Along with observed trends in select cytokines, findings encourage a more definitive trial aimed at understanding the short-term effects of yoga exercise on inflammatory immune markers and pain in sedentary healthy adults. Clinicaltrials.gov ID# NCT04444102.
Popliteal Blood Flow With Lower-Extremity Injury Mobility Devices
Authors: Bradley Adam P. , Roehl Alexis S. , McGrath Ryan , Smith Joseph , Hackney Kyle J. 
Published: December 2022

Background: Ambulation devices may differ in their utility, muscle activation patterns, and how they affect regional blood flow. This study aimed to evaluate popliteal blood flow and vessel dimensions in response to ambulation with a hands-free crutch (HFC), axillary crutches (AC), a medical kneeling scooter (MKS), and regular walking in healthy adults. Methods: HFC, AC, MKS, and regular walking were completed in a random order by 40 adults aged 18-45 years. Participants ambulated at a comfortable pace for 10 minutes with each device. At baseline and immediately following each trial, a trained operator used diagnostic ultrasonography to capture popliteal vein and artery dimensional and flow characteristics. Results: Significant increases were observed from baseline (0.65 ± 0.23 cm) in venous diameter following walking (0.71 ± 0.21 cm, P = .012) and MKS (0.73 ± 0.21 cm, P = .003). Venous blood flow was also significantly different between conditions ( P = .009) but was only greater following walking (124 ± 79 mL/min) compared to MKS (90 ± 64 mL/min, P = .021). No differences were observed in arterial dimensions between ambulation conditions. Significant increases were found in arterial blood flow from baseline (107 ± 69 mL/min) following walking (184 ± 97 mL/min, P < .001) and HFC (163 ± 86 mL/min, P < .001). Arterial blood flow following walking was greater than AC (132 ± 72 mL/min, P = .016) and MKS (128 ± 74 mL/min, P = .003). Conclusion: We found an average decrease in venous time-averaged mean velocity between walking and use of the MKS, but no such decrease with either HFCs or use of ACs in this healthy experimental cohort. Level of Evidence: Level III, diagnostic comparative study.
Scientists’ and teachers’ attitudes toward relating to religion when teaching evolution
Authors: Stahi-Hitin Reut , Yarden Anat 
Published: December 2022

Abstract
Background
The presumed conflict between religion and evolution is considered one of the main causes for rejection of evolution worldwide. It has been shown that when students′ perceived conflict is not answered, they may not accept evolution. However, there is a debate in the literature whether teachers should relate to students’ religious faith in evolution class, although teachers tend to agree that it should be related. The aim of this study was to explore the attitudes of scientists and teachers, toward relating to religion when teaching evolution.

Results
When scientists (n = 124) were asked in an online survey whether teachers should relate to religion when teaching evolution, most scientists said teachers should not relate to religion, in contrary to teachers who were asked the same question and said that teachers should relate to religion. When religious teachers (n = 10) and scientists (n = 10) were asked the same question—all the religious teachers agreed that teachers should relate to religion, emphasizing mainly the importance of connecting to the students’ inner world, preparing students for the future, etc. Most religious scientists also agreed, although they were more hesitant and emphasized the challenges and limitations of relating to religion in a science class. When asked how to relate to the issue, the teachers emphasized the importance of relating to the students’ culture and self-choice. Moreover, they took responsibility and emphasized it is their role to provide a proper response to their students. Most interviewed scientists emphasized that the boundaries between science and religion should be emphasized clearly by the teacher, and some suggested that biology teachers themselves should not discuss the issue, but that an external figure such as a rabbi or the religion/bible teacher should do it.

Conclusions
When discussing the issue of relating to religion in a science class, the differences between scientists and teachers that were identified here emphasize the need to relate to teachers’ experiences in this academic discussion, as they are aware of their students’ difficulties. In addition, it is important to consider the attitudes of religious scientists and teachers, as they demonstrate the possible co-existence between religion and science in their own life, thus they understand the conflict and may have practical solutions to it. Teachers’ professional development programs in this issue, may help teachers face with the limitations and challenges that the presumed conflict between religion and evolution may create.
Improving automatic GO annotation with semantic similarity
Authors: Sarker Bishnu , Khare Navya , Devignes Marie-Dominique , Aridhi Sabeur 
Published: December 2022

AbstractBackgroundAutomatic functional annotation of proteins is an open research problem in bioinformatics. The growing number of protein entries in public databases, for example in UniProtKB, poses challenges in manual functional annotation. Manual annotation requires expert human curators to search and read related research articles, interpret the results, and assign the annotations to the proteins. Thus, it is a time-consuming and expensive process. Therefore, designing computational tools to perform automatic annotation leveraging the high quality manual annotations that already exist in UniProtKB/SwissProt is an important research problemResultsIn this paper, we extend and adapt the GrAPFI (graph-based automatic protein function inference) (Sarker et al. in BMC Bioinform 21, 2020; Sarker et al., in: Proceedings of 7th international conference on complex networks and their applications, Cambridge, 2018) method for automatic annotation of proteins with gene ontology (GO) terms renaming it as GrAPFI-GO. The original GrAPFI method uses label propagation in a similarity graph where proteins are linked through the domains, families, and superfamilies that they share. Here, we also explore various types of similarity measures based on common neighbors in the graph. Moreover, GO terms are arranged in a hierarchical manner according to semantic parent–child relations. Therefore, we propose an efficient pruning and post-processing technique that integrates both semantic similarity and hierarchical relations between the GO terms. We produce experimental results comparing the GrAPFI-GO method with and without considering common neighbors similarity. We also test the performance of GrAPFI-GO and other annotation tools for GO annotation on a benchmark of proteins with and without the proposed pruning and post-processing procedure.ConclusionOur results show that the proposed semantic hierarchical post-processing potentially improves the performance of GrAPFI-GO and of other annotation tools as well. Thus, GrAPFI-GO exposes an original efficient and reusable procedure, to exploit the semantic relations among the GO terms in order to improve the automatic annotation of protein functions