bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alta ingestão de alimentos ultra processados durante a pandemia em pessoas com ansiedade e depressão
Authors: Goes Samara Julia da Cunha , Figueiredo Rebeca Sakamoto , Ferreira José Carlos de Sales 
Published: November 2022

Introdução: Diante o atual cenário de a pandemia de COVID-19, é razoável esperar que muitos comportamentos sejam modificados, sendo um deles a alimentação. analisando o alto consumo de ultra processados e os fatores alimentares que implicam na saúde psica. Objetivo: objetiva-se investigar a interrelação entre a incidência do alto consumo de alimentos ultra processados durante a pandemia de COVID-19 e a influência desses alimentos no organismo e saúde mental destacando pessoas com ansiedade e depressão. Método: No presente estudo foi realizado um estudo de cunho quali-quantitativo, de revisão de literatura, que abrangeu livros, revistas, Diretrizes Sociedades Brasileiras, bases de artigos em sites Pubmed, Acadêmico (Scholar.Google), Scientific Electronic Library Online (Biblioteca Científica Eletrônica On-line) nos anos de 2020. Resultados: Há pretensão de contribuir com informações sobre o tema com intuito de despertar uma nova visão e conhecimentos ao público em questão, onde possa contribuir de forma positiva no âmbito alimentar de pessoas com ansiedade e depressão.
Análise espacial e temporal da mortalidade por câncer gástrico no Brasil, 2001 a 2020
Authors: Hora Brunna Karolyne Souza , Pereira Pedro Costa , Brito Maria Santos , Cedraz Maria Eduarda Santos , Britto Neto Horley Soares , Melo Ana Catarine Cardoso de , Gois Yasmim Doria Cardoso , Jesus Carla Viviane Freitas de , Batista Jefferson Felipe Calazans , Lima Sonia Oliveira 
Published: November 2022

Objetivo: Analisar temporal e espacialmente a mortalidade por câncer de estômago no Brasil e suas regiões no período de 2001 a 2020. Metodologia: Trata-se de um estudo ecológico sobre a mortalidade por neoplasias malignas do estômago no Brasil e suas regiões, no período de 2001 a 2020. Os dados foram provenientes do Sistema de Informação Sobre Mortalidade (SIM). As Taxas de Mortalidade foram calculadas e padronizadas usando o método direto. Realizou-se uma análise de tendência temporal por meio da técnica de JoinPoint. A análise espacial foi realizada por meio do Índice Global e Local de Moran. Resultados: No brasil, foram registradas 171.464 mortes por câncer gástrico, no sexo masculino com Taxa Padronizada de Mortalidade (TPM) média de 16,72 óbitos para cada 100 mil homens. A tendência temporal, no sexo masculino, foi de declínio no Brasil (Variação Percentual Anual Média - VPAM= -2,4% e no feminino -1,8% (p<0,05). O Sul, Sudeste e Centro Oeste apresentaram redução (VPAM=-3,0%, -3,5% e -2,9%, respectivamente). No Norte as taxas foram estacionárias (p>0,05) e no Nordeste houve aumento (VPAM=0,8%). regiões como Sudeste e Sul e parte do Nordeste (Ceará) apresentaram conglomerados espaciais com altas taxas de mortalidade em ambos os sexos. Conclusão: A tendência temporal demonstrou que as taxas padronizadas de mortalidade estão em declive no Brasil, na região Sul, Sudeste e Centro-Oeste, enquanto mostrou-se estável no Norte e aumento no Nordeste. Municípios do Sudeste e Sul e parte do Nordeste apresentaram aglomerados com altas taxas.
Outcomes of catheter ablation of ventricular tachycardia in non-ischemic idiopathic dilated cardiomyopathy: A systematic review and meta-analysis
Authors: Ammar Ahmed , Sharief Mohamed , Abouelmagd Khaled , Riad Omar , Ibrahim Mokhtar 
Published: November 2022

ObjectiveTo perform a systematic review and meta-analysis of available trials regarding the outcomes of ventricular tachycardia (VT) ablation in patients with non-ischemic dilated cardiomyopathy (NIDCM).MethodsA comprehensive database search of large four electronic databases, including PubMed, Cochrane, Scopus, and Institute for Scientific Information network meta-analysis, identified five studies enrolling 666 patients for patients with idiopathic dilated cardiomyopathy (IDCM) underwent catheter ablation (CA) for VT. The short-term outcomes assessed included procedural success, VT non-inducibility and procedural complications, whereas the long-term outcomes assessed included VT recurrence, heart transplantation, antiarrhythmic drugs (AAD) use after ablation and death.ResultsA total of 5 observational studies reported outcomes in 666 patients with NIDCM undergoing VT CA. The complete procedural success was moderately high; 65.5% of the patients (95% CI 0.402- 0.857, p &lt; 0.001) and the procedural complications occurred in 5.8% of the patients (95% CI 0.040–0.076, P = 0.685). Epicardial mapping and ablation were performed among 61.5% and 37% of patients with NIDCM respectively. During a follow up period of 12 to 45 months, there were VT recurrence in 34.2% of the patients (95% CI 0.301–0.465, p &lt; 0.080), death in 20.2% of the patients (95% CI 0.059–0.283, p &lt; 0.017) and heart transplantation in 12.9% of the patients (95% CI −0.026–0.245, P &lt; 0.012).ConclusionVentricular tachycardia CA is effective and safe approach for management of patients with NIDCM with the epicardial approach to be considered as initial strategy especially in presence of ECG and CMR findings suggestive of epicardial substrate. A multicenter randomized trial is crucial to look at the short- and long-term outcomes of VT ablation in NIDCM especially with the advances in mapping and ablation techniques and predictors of success.
A model to design financially sustainable algorithm-enabled remote patient monitoring for pediatric type 1 diabetes care
Authors: Dupenloup Paul , Pei Ryan Leonard , Chang Annie , Gao Michael Z. , Prahalad Priya , Johari Ramesh , Schulman Kevin , Addala Ananta , Zaharieva Dessi P. , Maahs David M. , Scheinker David 
Published: November 2022

IntroductionPopulation-level algorithm-enabled remote patient monitoring (RPM) based on continuous glucose monitor (CGM) data review has been shown to improve clinical outcomes in diabetes patients, especially children. However, existing reimbursement models are geared towards the direct provision of clinic care, not population health management. We developed a financial model to assist pediatric type 1 diabetes (T1D) clinics design financially sustainable RPM programs based on algorithm-enabled review of CGM data.MethodsData were gathered from a weekly RPM program for 302 pediatric patients with T1D at Lucile Packard Children’s Hospital. We created a customizable financial model to calculate the yearly marginal costs and revenues of providing diabetes education. We consider a baseline or status quo scenario and compare it to two different care delivery scenarios, in which routine appointments are supplemented with algorithm-enabled, flexible, message-based contacts delivered according to patient need. We use the model to estimate the minimum reimbursement rate needed for telemedicine contacts to maintain revenue-neutrality and not suffer an adverse impact to the bottom line.ResultsThe financial model estimates that in both scenarios, an average reimbursement rate of roughly $10.00 USD per telehealth interaction would be sufficient to maintain revenue-neutrality. Algorithm-enabled RPM could potentially be billed for using existing RPM CPT codes and lead to margin expansion.ConclusionWe designed a model which evaluates the financial impact of adopting algorithm-enabled RPM in a pediatric endocrinology clinic serving T1D patients. This model establishes a clear threshold reimbursement value for maintaining revenue-neutrality, as well as an estimate of potential RPM reimbursement revenue which could be billed for. It may serve as a useful financial-planning tool for a pediatric T1D clinic seeking to leverage algorithm-enabled RPM to provide flexible, more timely interventions to its patients.
Life-course blood pressure trajectories and incident diabetes: A longitudinal cohort in a Chinese population
Authors: Liu Ying , Chen Xiaohong , Li Chunxia , Fan Bingbing , Lv Jiali , Qu Yanlin , Cai Yongjiang , Zhang Tao 
Published: November 2022

BackgroundBlood pressure levels are correlated with diabetes among middle-aged or older adults. However, longitudinal trajectories of blood pressure during young adulthood and their impact on diabetes have been insufficiently studied.MethodsThe longitudinal cohort consisted of 4,625 adults who had blood pressure and body mass index (BMI) repeatedly measured five to nine times during 18–60 years of age. Distinct systolic blood pressure (SBP) trajectories were identified by a group-based trajectory model. Logistic regression analyses were used to investigate the association between trajectory patterns or quartiles of area under the curve values of SBP trajectories and incident diabetes, respectively.ResultsFour distinct trajectory groups were identified for SBP: normotensive-stable (n = 761, 16.5%), prehypertension-stable (n = 2,381, 51.5%), stage I hypertension-increasing (n = 1,231, 26.6%), and stage II hypertension-increasing (n = 251, 5.4%). Compared with subjects who remained at SBP &lt;120 mmHg in the normotensive-stable group, individuals in the prehypertension-stable trajectory exhibited a normal SBP range (&lt;140 mmHg), and they still had a significantly higher risk of diabetes (adjusted OR = 1.82, p = 0.029). Individuals had a greater risk of diabetes in the stage I hypertension-increasing group (adjusted OR = 2.31, p = 0.006) and the highest risk in the stage II hypertension-increasing group (adjusted OR = 3.91, p &lt; 0.001) relative to the normotensive-stable group. Furthermore, compared with the first quartile, adjusted ORs (95% CIs) of the fourth quartile of SBP incremental and total AUC were 2.50 (1.61–3.97) and 1.82 (1.15–2.94), respectively.ConclusionsLong-term SBP trajectory is a significant predictor for incident diabetes, which is independent of baseline SBP and body weight, attaching importance to maintaining optimal blood pressure levels and controlling changing slopes of SBP for preventing diabetes.
Case report: Molecular analysis of a 47,XY,+21/46,XX chimera using SNP microarray and review of literature
Authors: Charalsawadi Chariyawan , Jaruratanasirikul Somchit , Hnoonual Areerat , Chantarapong Aussanai , Sangmanee Pornsiri , Trongnit Sasipong , Jinawath Natini , Limprasert Pornprot 
Published: November 2022

Chimerism is a very rare genetic finding in human. Most reported cases have a chi 46,XX/46,XY karyotype. Only three non-twin cases carrying both trisomy 21 and a normal karyotype have been reported, including two cases with a chi 47,XY,+21/46,XX karyotype and a case with a chi 47,XX,+21/46,XY karyotype. Herein we describe an additional case with a chi 47,XY,+21/46,XX karyotype. For the case, a physical examination at the age of 1 year revealed ambiguous genitalia with no features of Down syndrome or other malformations. Growth and developmental milestones were within normal ranges. We performed short tandem repeat (STR) and single nucleotide polymorphism (SNP) microarray analyses to attempt to identify the mechanism underlying the chimerism in this patient and the origin of the extra chromosome 21. Cytogenetic analyses of the patient’s peripheral blood revealed approximately 17% of a 47,XY,+21 lineage by G-banding karyotype analysis, 13%–17% by FISH analyses of uncultured peripheral blood, and 10%–15% by SNP microarray analysis. Four years later, the percentage of trisomy 21 cells had decreased to approximately 6%. SNP microarray and STR analyses revealed a single maternal and double paternal genetic contribution to the patient for the majority of the markers, including the chromosome 21 markers. The extra chromosome 21 was paternally derived and meiosis I nondisjunction likely occurred during spermatogenesis. The mechanisms underlying chimera in our case was likely fertilization two spermatozoa, one with an ovum and the other with the second polar body.
Efficacy and safety of copanlisib in relapsed/refractory B-cell non-Hodgkin lymphoma: A meta-analysis of prospective clinical trials
Authors: Wang Jinjin , Zhou Hui , Mu Mingchun , Zhao Ailin , Cai Zhaolun , Li Linfeng , Wang Mengyao , Niu Ting 
Published: November 2022

BackgroundCopanlisib is an intravenously administered pan-class I PI3K inhibitor that has been demonstrated to have appreciable effects in the treatment of patients with lymphoma. The purpose of this meta-analysis was to evaluate the efficacy and safety of copanlisib for treating patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL).MethodsPubMed, Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for relevant studies published prior to July 2022. The efficacy evaluation included complete response rate (CR), partial response rate (PR), rate of stable disease (SDR), overall response rate (ORR), disease control rate (DCR), rate of progressive disease (PDR), median progression-free survival (PFS), and median overall survival (OS). Any grade adverse events (AEs) and grade ≥3 AEs were synthesized to assess its safety.ResultsEight studies with a total of 652 patients with R/R B-NHL were identified. The pooled CR, PR, ORR, SDR, DCR, and PDR from all 8 articles were 13%, 40%, 57%, 19%, 86%, and 9%, respectively. The CR and ORR of combination therapy with rituximab were higher than those with copanlisib monotherapy for R/R B-NHL (34% vs. 6%, p&lt;0.01; 89% vs. 42%, p&lt;0.01). For patients with R/R indolent B-NHL, CR and ORR were lower with copanlisib monotherapy than with combination therapy with rituximab (7% vs. 34%, p&lt;0.01; 58% vs. 92%, p&lt;0.01). In R/R B-NHL patients receiving copanlisib monotherapy and combination therapy with rituximab, the risk of any grade AEs was 99% and 96%, respectively, and the risk of grade ≥3 AEs was 84% and 91%, respectively. The common any grade AEs included hyperglycemia (66.75%), hypertension (48.57%), diarrhea (35.06%), nausea (34.98%) and fatigue (30.33%). The common grade ≥3 AEs included hyperglycemia (45.14%), hypertension (35.07%), and neutropenia (14.75%). The comparison of AEs between the copanlisib monotherapy and the combination therapy with rituximab showed that hyperglycemia of any grade (p&lt;0.0001), hypertension of any grade (p=0.0368), fatigue of any grade (p&lt;0.0001), grade ≥3 hypertension (p&lt;0.0001) and grade ≥3 hyperglycemia (p=0.0074) were significantly different between the two groups.ConclusionOur meta-analysis demonstrated that the efficacy of both copanlisib monotherapy and combination therapy with rituximab in patients with R/R B-NHL was satisfactory, while treatment-related AEs were tolerable. Compared with copanlisib monotherapy, combination therapy with rituximab showed superior efficacy for treating R/R B-NHL, and its safety was manageable.Systematic Review Registrationhttps://inplasy.com/inplasy-2022-10-0008/, identifier INPLASY2022100008.
Implication of platelets and complement C3 as link between innate immunity and tubulointerstitial injury in renal vasculitis with MPO-ANCA seropositivity
Authors: Baier Eva , Tampe Désirée , Kluge Ingmar Alexander , Hakroush Samy , Tampe Björn 
Published: November 2022

IntroductionAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic small-vessel vasculitis that is characterized by pauci-immune glomerulonephritis, depicting in turn a major denominator of AAV mortality. It is well established that AAV patients feature an increased risk of developing thrombotic events, and platelets are activated in AAV patients being triggered by the alternative complement pathway. Platelets guard vessels integrity and initiate thrombus formation in response to endothelial damage, further constituting a triangular interconnection with the activation of neutrophils and the complement system. We here aimed to systematically assess the relevance of platelet counts and systemic complement system activation regarding distinct histopathological lesions in ANCA-associated renal vasculitis.MethodsA cohort of 53 biopsy-proven cases of ANCA-associated renal vasculitis were retrospectively enrolled in a single-center observational study. Univariate and multivariate regression analysis was performed to identify parameters associated with platelet counts in ANCA-associated renal vasculitis compared to disease controls. Finally, the relevance of platelets for disease course and recovery was assessed by survival analysis.ResultsLower platelet counts correlated with markers of kidney injury including eGFR loss (p=0.0004) and lower complement C3 levels (p=0.0037). Multivariate and subgroup analysis revealed that this association was only present in the subgroup with MPO-ANCA seropositivity (eGFR loss: p=0.0009, lower C3: p=0.0032). While lower platelet counts correlated with kidney injury in the PR3-ANCA subgroup (eGFR loss: p=0.0272), we did not observe an independent association with complement C3 levels (p=0.4497). Independent of any glomerular lesion, lower platelet counts correlated with interstitial fibrosis (p=0.0313), tubular atrophy (p=0.0073), and tubulitis in areas of interstitial fibrosis and tubular atrophy (p=0.0033). Finally, we observed significant differences with increased requirement of kidney replacement therapy (KRT) or death in the subgroup below median platelet counts (HR: 4.1, 95% CI: 1.6-10, p=0.0047), associated with a lower probability of discharge and prolonged hospitalization in this subgroup (HR: 0.5, 95% CI: 0.3-0.9, p=0.0113).ConclusionBased on our observation that an association between platelets and complement system activation is only observed in the MPO-ANCA subgroup, this could implicate that platelets and complement C3 link innate immunity to tubulointerstitial injury in the presence of MPO-ANCA autoantibodies.
Altered cerebellar functional connectivity in chronic subcortical stroke patients
Authors: Hong Wenjun , Du Yilin , Xu Rong , Zhang Xin , Liu Zaixing , Li Ming , Yu Zhixuan , Wang Yuxin , Wang Minmin , Yang Bo , Sun Fenfen , Xu Guangxu 
Published: November 2022

BackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the functional connectivity (FC) alterations of CAL and CPL, and their relationships with behavior performance in chronic stroke participants are unclear so far.Materials and methodsThe present study collected resting-state fMRI data from thirty-six subcortical chronic stroke participants and thirty-eight well-matched healthy controls (HCs). We performed the FC analysis with bilateral CAL and CPL as seeds for each participant. Then, we detected the FC difference between the two groups by using a two-sample t-test and evaluated the relationship between the FC and scores of motor and cognitive assessments across all post-stroke participants by using partial correlation analysis.ResultsThe CAL showed increased FCs in the prefrontal cortex, superior/inferior temporal gyrus, and lingual gyrus, while the CPL showed increased FCs in the inferior parietal lobule, precuneus, and cingulum gyrus in the stroke participants compared with HCs. Moreover, the FC alteration in the right CAL and the right CPL were negatively correlated with executive and memory functions across stroke participants, respectively.ConclusionThese findings shed light on the different increased FC alteration patterns of CAL and CPL that help understand the neuro-mechanisms underlying behavior performance in chronic stroke survivors.
Jain point laparoscopic entry in contraindications of Palmers point
Authors: Jain Nutan , Srivastava Sakshi , Bayya Sri Lakshmi Prasanna , Jain Vandana 
Published: November 2022

BackgroundThis study was conducted to assess the efficacy of the Jain point to overcome the contraindications of Palmer's point. The Jain point lies on the left side of the abdomen at the L4 level, 10–13 cm lateral to the umbilicus. Due to its anatomical location, the Jain point is free from adhesions because postsurgical adhesions are encountered usually in the midline or the right side.MethodsThis is a retrospective study conducted at a high-volume tertiary care referral center for advanced gynecological laparoscopic surgery, enrolling 8,586 patients who underwent laparoscopy at the center from January 2011 to March 2022. In this paper, we analyze 2,519 patients with a history of previous surgeries, who were operated using the Jain point.ResultsIn the 2,519 patients with a history of previous surgeries, the Jain point port was found to be adhesion free, regardless of the location of the scars, the number and type of previous surgeries, and those in whom Palmer's point was contraindicated. No major complications were reported, except for one case (0.04%) of small bowel injury, which was managed intraoperatively. The Jain point continued to function as the main ergonomic working port.ConclusionThe Jain point offers an alternate safe entry port in previous surgery cases for laparoscopic surgeons of various specialties, like general surgeons, urologists, oncologists, and bariatric surgeons, to overcome the contraindications of Palmer's point. The Jain point also acts as the main ergonomic working port, whereas Palmer's point becomes redundant after initial entry.
Scientific and Fisher’s Knowledge-Based Ecological Risk Assessment: Combining Approaches to Determine the Vulnerability of Fisheries Stocks
Authors: Peixoto Ualerson Iran , Casal-Ribeiro Morgan , Medeiros-Leal Wendell M. , Novoa-Pabon Ana , Pinho Mário , Santos Régis 
Published: November 2022

Small-scale fishing is a multi-gear activity that focuses on a wide range of species. As there is a considerable diversity of species, it is often difficult to keep track of all of those that are caught, and due to the lack of data or poor quality, most stock statuses are currently unknown around the world. Therefore, local ecological knowledge provided by fishers has been regarded as a valuable source of information to bridge these crucial gaps. This study assesses the vulnerability status of 22 fishing stocks in the Azores, through productivity and susceptibility analyses (PSAs) using two independent data sources: conventional scientific knowledge and fishers’ knowledge data. We created four PSAs with separate and integrated data sources. Although we found some differences in the vulnerability scores and rankings, the risk outputs of the PSAs using independent and integrated sources of data generally match, reflecting a similar pattern trend. The findings of this work suggest that integrating FK may be an alternative to provide good fisheries’ assessment outcomes in the absence of CSK. Overall, this research supports the inclusion of fishers’ knowledge in vulnerability assessments as not only beneficial in the absence of data, but also as a supplement to data that can improve management advice.