bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies for Cluster Branding in MSMEs Clusters: A Grounded Theory Approach
Authors: Bhamra Manmeet , Kishore Kaushal 
Published: October 2022

Cluster initiatives are an essential way to increase the competitiveness of enterprises, especially micro, small and medium enterprises (MSMEs) within the region. Therefore, building a strong cluster brand is a prerequisite for a successful cluster initiative. However, the concept of cluster branding in MSMEs handloom clusters remains unexplored in India. The drive of this research was to examine the role of branding as a strategic asset and how it plays an instrumental role in the overall growth of MSMEs clusters, with a specific focus on handloom clusters of Gujarat, India. Using the grounded theory approach, semi-structured interviews were conducted in the Surendranagar saree cluster in Gujarat, India. The study led to the formulation of strategies for cluster branding, along with the benefits and impacts on member MSMEs of the handloom cluster. Finally, a framework is proposed as the outcome of qualitative research which may be helpful to the stakeholders in taking the clusters to the next level in the era of globalization and competitive environment.
Self-Reported Causes of Psychological Distress Among Czech Perinatal Women
Authors: Hrdličková Kristýna , Banášová Renata , Nosková Eliška , Vodičková Renata , Byatt Nancy , Šebela Antonín 
Published: October 2022

Background: Various risk factors to perinatal mental health disorders have been described; however, there is a dearth of data on the perspectives of women themselves regarding what increases the risk of psychological distress. This qualitative study explores women’s perceptions of factors that increase the risk of perinatal psychological distress. Aim: The aim of this study was to elucidate women’s perceptions of factors that increase the risk of perinatal psychological distress. Methods: A qualitative design with an exploratory and descriptive approach is used. Women ( N = 188) aged 18 to 45 years who self-report experiencing perinatal psychological distress complete an online survey. Results: Perceived causes of perinatal psychological distress include: adverse experiences with childbirth and/or breastfeeding, negative attitudes of people close to the participant, financial and social challenges, health challenges, staff behavior in a maternity hospital, a challenging baby, family circumstances, and the new role as mother. Conclusion: Women’s perceived causes of perinatal psychological distress may allow for women-centered innovations in perinatal mental health care. The results highlight the need to train maternity staff regarding perinatal mental health and communication. These findings can serve as important guidelines on women-centered planning of innovations of perinatal mental health care. Interventions need to focus on the role of partners and others close to women so as to support the women during the perinatal period.
Soberanía alimentaria y salud: perspectivas de tres pueblos indígenas de Colombia
Authors: Calderón Farfán Juan Camilo , Rosero Medina Diego Fernando , Arias Torres Dolly 
Published: October 2022

Resumen: La soberanía alimentaria es el derecho colectivo a decidir sobre la producción, distribución y consumo de alimentos y promueve la generación de suministros alimenticios para el consumo local de tal forma que los consumidores queden resguardados de la volatilidad de los precios de mercados internacionales. En los pueblos indígenas esta tendencia resulta trascendental para hacer frente a condiciones de inequidad histórica que han impactado negativamente su salud pública. No obstante, es ignorada en algunos casos y en otros reemplazada por nociones centradas en la seguridad alimentaria, término alineado con políticas transnacionales derivadas del modelo económico dominante. Objetivo: analizar con tres comunidades indígenas de Colombia las perspectivas de soberanía alimentaria y su influencia en la salud. Método: investigación participativa basada en la comunidad, para recolectar datos mediante grupos de discusión, entrevistas y observación. La población de estudio fueron tres comunidades indígenas del sur de Colombia. La selección de participantes se realizó según su trayectoria en la comunidad. Resultados: las comunidades entienden la soberanía alimentaria como la conservación de semillas nativas y alimentos propios, vista como oportunidad para el cuidado de la salud. Su debilitamiento se relaciona con el desarrollo de enfermedades de las personas y de la madre tierra. Para su fortalecimiento identificaron el tul, el yatul y la chagra (huerta) que reafirman la unión familiar, contribuyen a la recuperación de modos de producción desde la sabiduría ancestral y se posicionan como alternativa para la sostenibilidad económica. Conclusión: la soberanía alimentaria conserva los saberes y prácticas tradicionales para una alimentación propia, debilitada por los sistemas agroindustriales. Es asumida como iniciativa local suscrita en un proyecto global de resistencia política y económica para la salud colectiva de los pueblos.
Mutations in lysine methyltransferase 2C and PEG3 are associated with tumor mutation burden, prognosis, and antitumor immunity in pancreatic adenocarcinoma patients
Authors: Huang Yili , Liu Jinsong , Zhu Xiaole 
Published: October 2022

Background As a common cancer-related death worldwide, pancreatic adenocarcinoma (PAAD) has significantly increased mortality in recent years. In recent years, tumor mutation burden (TMB) has been regarded as the most popular biomarker for PAAD immunotherapy. However, it remains unclear which gene mutations affect TMB and immune response in pancreatic adenocarcinoma. Methods The somatic mutation images of PAAD samples were downloaded from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC). Based on the expression data of the TCGA and IGCC cohorts, various bioinformatics algorithms are used for evaluating the prognostic value and functional annotation of some frequently somatically mutated genes. Furthermore, the correlation between gene mutation and tumor immunity was also evaluated. Results The results showed that lysine methyltransferase 2C (KMT2C) and paternally expressed 3 (PEG3) are frequently mutated genes in PAAD. Patients with KMT2C and PEG3 mutations have higher TMB severity and a lousy prognosis. In addition, the mutations of KMT2C and PEG3 genes positively regulate the metabolic and protein-related pathways in PAAD. Meanwhile, significant differences in the composition of the immune cells were observed for KMT2C and PEG3 mutations PAAD patients, for providing additional guidelines for antitumor treatments in various KMT2C and PEG3 mutation states in PAAD. Conclusion This study reveals that KMT2C and PEG3 mutation may serve as biomarkers for predicting prognosis and guiding anti-PAAD immunotherapy for PAAD patients.
Phosphaturic mesenchymal tumor in right thigh: 2 cases report and literature review
Authors: Wang Ruifeng , Zhou Jiayu , Yu Yupei , Deng Junqi , Wu Ze , Ou Chunlin , Wu Yanhao , Yang Keda , Wang Junpu 
Published: October 2022

Background: Phosphaturic mesenchymal tumor (PMT) is a very rare tumor of bone and soft tissue that has no specific clinical manifestations. Here we present 2 cases of PMT in the right thigh, including comparatively adequate immunohistochemistry. Case Presentation: We described 2 cases of PMT in the right thigh with manifestations of hypophosphatemia. PET-CT examination showed that both patients had lesions with increased expression of somatostatin receptors in the right thigh. Bland cells and dirty calcified stroma were exhibited under the microscope. And immunohistochemical detection of FGF-23 was positive. Conclusions: PMT is a very uncommon tumor for which diagnosis and treatment are often delayed. Considering the importance of surgery for the treatment of this disease, a full understanding of its clinicopathological features will facilitate the diagnosis of this disease.
Single object profiles regression analysis (SOPRA): a novel method for analyzing high-content cell-based screens
Authors: Gurumurthy Rajendra Kumar , Pleissner Klaus-Peter , Chumduri Cindrilla , Meyer Thomas F. , Mäurer André P. 
Published: October 2022

Abstract
Background
High-content screening (HCS) experiments generate complex data from multiple object features for each cell within a treated population. Usually, these data are analyzed by using population-averaged values of the features of interest, increasing the amount of false positives and the need for intensive follow-up validation. Therefore, there is a strong need for novel approaches with reproducible hit prediction by identifying significantly altered cell populations.

Results
Here we describe SOPRA, a workflow for analyzing image-based HCS data based on regression analysis of non-averaged object features from cell populations, which can be run on hundreds of samples using different cell features. Following plate-wise normalization, the values are counted within predetermined binning intervals, generating unique frequency distribution profiles (histograms) for each population, which are then normalized to control populations (control-based normalization). These control-normalized frequency distribution profiles are analyzed using the Bioconductor R-package maSigPro, originally developed to analyze time profiles. However, statistically significant altered frequency distributions are also identified by maSigPro when integrating it into the SOPRA workflow. Finally, significantly changed profiles can be used to generate a heatmap from which altered cell populations with similar phenotypes can be identified, enabling the detection of siRNAs and compounds with the same ‘on-target’ profile and reducing the number of false positive hits.

Conclusions
SOPRA is a novel analysis workflow for the detection of statistically significant normalized frequency distribution profiles of cellular features generated in high-throughput RNAi screens. For the validation of the SOPRA software workflow, a screen for cell cycle progression was used. We were able to identify such profiles for siRNA-mediated gene perturbations and chemical inhibitors of different cell cycle stages. The SOPRA software is freely available from Github.
Population attributable fractions for risk factors and disability burden of dementia in Jiangxi Province, China: a cross-sectional study
Authors: Wu Yuhang , Zheng Huilie , Xu Fenfei , Guo Jin , Liu Zhitao , Wang Shengwei , Chen Xiaoyun , Cao Yu , Zou Wei , Hu Songbo 
Published: October 2022

Abstract
Background
In view of the fact that there is no effective treatment for dementia, the number of years that dementia patients have to live with dementia will gradually increase for the rest of their lives, and the disability loss caused by dementia will increase. It is urgent to study the influence of risk factors on dementia by making use of the potential of prevention. The purpose of this study is to quantify the burden of dementia disability attributable to risk factors by assessing the population attributable fractions (PAFs) in Jiangxi Province, which is one of the regions of moderate aging process of China.

Methods
The prevalence data of nine risk factors were obtained through the Sixth National Health Service Survey in 2018, which covered 2713 older people. Levin’s formula was used to calculate the PAF for each risk factor for dementia. We adjusted the PAF for communality between risk factors, and used these values to calculate overall weighted PAFs and the years lived with disability (YLDs), which were attributable to nine risk factors.

Results
The number of dementia cases and their proportions that can theoretically be prevented by nine identified risk factors were 111636 (99595-120877) and 66.8% (59.6-72.3), respectively. The total YLDs of dementia were estimated to be 61136 (46463-78369) (males: 36434 [24100-49330], females: 23956 [14716-34589]). Physical inactivity (11639 [8845-14920]), low social contact (9324 [7086-11952]), and hearing loss (5668 [4307-7265] were the top three contributors to dementia.

Conclusions
The moderate aging areas represented by Jiangxi Province have great potential in the prevention of dementia. Targeted interventions and management of risk factors can effectively reduce the disability burden of dementia.
Effects of self-management exercise group participation in community-dwelling older adults
Authors: Yokozuka Mieko , Okazaki Kanako , Hoshi Masayuki , Shiine Ayumi , Fukumoto Tomoko 
Published: October 2022

Abstract
Background
The effects of physical fitness and age on motor function in older adults who continue to exercise remain unclear. This study aimed to examine the effects of participation in self-management exercise groups in adults aged ≥65 years.

Methods
The motor functions of 372 citizens who participated in a self-management exercise group for 1 year were examined. The motor functions were assessed by measuring grip strength, five-repetition sit-to-stand test, 5-m fastest walking time (walking time) and timed up and go test. The participants were grouped according to their baseline grip strength (low or high grip strength groups). The baseline parameters were compared to those assessed 1 year after group participation. In addition, the rates of long-term care/support need certification were examined at 2-year follow-up.

Results
In the low grip strength group aged ≥75 years, the grip strength of men, and grip strength and five-repetition sit-to-stand test results of women improved after 1 year. In the high grip strength group, the five-repetition sit-to-stand and timed up and go test results of men aged 65–74 years and five-repetition sit-to-stand test results of men aged ≥75 years improved. Among women in the high grip strength group, grip strength, five-repetition sit-to-stand test, walking time, and timed up and go test results improved in the participants aged 65–74 and ≥ 75 years. The number of new long-term care/support need certifications was comparable in both groups.

Conclusions
Participation in self-management exercise groups led to maintaining or improving physical fitness among community-dwelling-older adults. Furthermore, higher baseline grip strength was associated with improvements in many motor functions; therefore, participation in self-management exercise groups before the onset of functional decline is desirable.
A unique case of anti-GBM disease with concomitant anti-PLA2R positivity
Authors: Molnár Adél , Tislér András , Dobi Deján , Pethő Ákos 
Published: October 2022

Abstract
Background
Concomitant occurrence of anti-GBM disease and anti-PLA2R positive membranous nephropathy have been previously described. However, to the best of our knowledge, this is the first case report that documents the co-occurrence of the diseases proven by both serologic and histologic methods.

Case presentation
A 51-year-old woman presented to hospital with nausea, bilateral lower extremity edema, dyspnea, dark urine, and then anuria. Symptoms developed one month after an upper respiratory tract infection. Laboratory results showed acute kidney injury, and hypoalbuminemia. Immunologic examination revealed both anti-GBM and anti-PLA2R positivity. Kidney biopsy demonstrated the histological features of Goodpasture’s disease and anti-PLA2R positive membranous nephropathy. Steroid, cyclophosphamide, and plasmapheresis were commenced. Despite the combined immunosuppressive, the patient remained on renal replacement therapy.

Conclusions
Microbial kidney injury can trigger multiple autoimmune diseases. The simultaneous occurrence of anti-glomerular basement (anti-GBM) disease and membranous nephropathy is extremely rare. Delayed recognition leads to delayed treatment, causing worse renal and patient outcomes, as well as increased financial costs.
Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes
Authors: Tang Chen-Ling , Tsai Wei-Chung , Lee Jui-Ying , Wang Yao-Kuang , Chen Yi-Hsun , Liu Yu-Wei , Lin Ming-Chieh , Fang Pen-Tzu , Huang Yu-Ling , Wu I-Chen 
Published: October 2022

Abstract
Background
Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer mortality in those with elevated resting heart rates (RHR). Skin sympathetic nerve activity (SKNA) is a new method of stimulating electrical signals in skin to evaluate autonomic function from sympathetic tone. In this study, we investigated the association between changes in RHR and autonomic function and ESCC mortality.

Methods
Thirty-nine stage II-IV ESCC patients receiving CRT between March 2019 and November 2020 were prospectively enrolled and carefully selected, followed up and received the same meticulous supportive care. Serial RHR was recorded every two weeks from before CRT to eight weeks after CRT and average SKNA were recorded before and four weeks after CRT. All-cause mortality was defined as primary outcome.

Results
We found the RHR of ESCC patients to be significantly elevated and peaking at four weeks after CRT (p < 0.001) and then to gradually decrease. Those with an elevated RHR above the cutoff level (18 beat-per-minute) at eight weeks after CRT had worse overall survival. In addition, those with higher baseline sympathetic tone (average SKNA ≥ 0.86 μV) also had poor outcome.

Conclusions
Increased pre-treatment sympathetic tone and elevated RHR after CRT are alarm signs of poor ESCC outcome. Further exploration of the mechanisms underlying these associations could potentially lead to intervention strategies for reducing mortality.

Trial registration
This study is registered with ClinicalTrials.gov, identifier: NCT03243448.
Mediating role of impaired wisdom in the relation between childhood trauma and psychotic-like experiences in Chinese college students: a nationwide cross-sectional study
Authors: Zhang Jiamei , Liu Zhening , Long Yicheng , Tao Haojuan , Ouyang Xuan , Wu Guowei , Chen Min , Yu Miaoyu , Zhou Liang , Sun Meng , Lv Dongsheng , Cui Guangcheng , Yi Qizhong , Tang Hong , An Cuixia , Wang Jianjian , Wu Zhipeng 
Published: October 2022

AbstractBackground:The association between childhood trauma (CT) and psychotic-like experiences (PLEs) is well-established. Many previous studies have recognized wisdom as a protective factor for mental health, but its role in the relation between CT and PLEs remains unknown. We aimed to investigate the mediating effect of wisdom in the above association among Chinese college students.Methods:We conducted a nationwide survey covering 9 colleges across China and recruited a total of 5873 students using online questionnaires between September 14 and October 18, 2021. Convenience sampling was adopted. We employed the San Diego Wisdom Scale (SD-WISE), the Childhood Trauma Questionnaire (CTQ-28), and the 15-item Positive Subscale of the Community Assessment of Psychic Experiences (CAPE-15) to measure the wisdom, CT and PLEs, respectively. Descriptive, correlation, and mediation analysis were utilized.Results:The positive correlation between CT and PLEs was well-replicated among college students (Pearson’s r = 0.30, p < 0.001). Wisdom was negatively associated with CT (Pearson’s r = − 0.46, p < 0.001) and frequency of PLEs (Pearson’s r = − 0.25, p < 0.001). Total wisdom scores partially mediated the relationship between cumulative childhood trauma, neglect, abuse and PLEs, separately. The mediated model respectively explained 21.9%, 42.54% and 18.27% of the effect of CT on PLEs. Our model further suggested that childhood trauma could be related to PLEs through decreasing the following wisdom components: decisiveness, emotional regulation and prosocial behavior.Conclusion:For the first time, our results suggested that impaired wisdom played a role in the translation from childhood adversity to subclinical psychotic symptoms, implicating wisdom as a possible target for early intervention for psychosis among young individuals. Longitudinal work is warranted to verify the clinical implications.
Physical activity and gestational weight gain: a systematic review of observational studies
Authors: Hamann Virginie , Deruelle Philippe , Enaux Christophe , Deguen Séverine , Kihal-Talantikite Wahida 
Published: October 2022

AbstractBackgroundNow that excessive weight gain during pregnancy is recognized as leading to complications during pregnancy that affect foetal growth, limiting weight gain during pregnancy has become a public health concern. Our aim was to perform a systematic review to assess whether observational studies reported associations between Physical Activity (PA) and Gestational Weight Gain (GWG). We were particularly interested in whether insufficient PA might be associated with high GWG.MethodsUsing Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we searched the MEDLINE ® databases for articles published up to February 2020 concerning case-control, cohort, and ecological studies assessing the association between PA during pregnancy and the risk of excessive and/or inadequate GWG.Results21 observational studies on the PA of pregnant women were screened. 11 of these focused on excessive GWG, and of these a majority tend to show a significant association between various aspects of PA and excessive GWG. However, the results were more mitigated when it came to rate of GWG: three studies found that neither meeting PA recommendations nor high levels of total PA nor time spent in moderate vigorous physical activity (MVPA) or engaged in sedentary behaviour were associated with weekly GWG, while two others suggested that pregnant women not meeting PA guidelines in late pregnancy did have a higher rate of GWG. Of the seven studies investigating total GWG, only one found no association with PA. All studies suggested an inverse association between PA and total GWG – yet not all studies are statistically significant.ConclusionDespite the small number of observational studies selected for our research, our findings support the main international findings, suggesting that active pregnant women gained less weight than inactive women; a lack of PA may therefore contribute to excessive GWG. The limitations of this body of evidence impede the formulation of firm conclusions. Further studies focusing clearly on the general PA assessment classification scheme are called for, to address limitations capable of affecting the strength of association.