bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key Principles of Governing Business-Incubator in University
Authors: Nachevskiy M. V. 
Published: October 2022

Efficiency of economy development directly depends on implementation of measures supporting business entities, including upgrading entrepreneurial infrastructure. This problem was repeatedly discussed at the highest level of state governance of the Russian Federation, in particular within the frames of the President of Russian address to the Federal Assembly in 2021. Business-incubators are a key element of such infrastructure. It should be pointed out that specialized literature has not thoroughly studied the issue of business-incubators functions in today’s economy. In general these functions can be differentiated in accordance with the stage of macro-economic development and overall strategy of finance and economic policy observed within the frames of a concrete state, depending on geopolitical situation, trends in global economy changes, possible foreign economic preferences and risks. Effectiveness of today’s incubator development, viewed both in finance and social aspect directly depends on the quality of methodological tools of their functioning efficiency appraisal. The article gives a classification of business-incubators by a number of important economic and managerial criteria, which gives a chance to find their most preferable type depending on strategic goals and objectives of developing the incubator’s founder and general functioning requirements of the relative territorial (federal, regional or municipal) system of entrepreneurial work support. The author underlines that today’s business-incubator should possess a multi-sectoral character, it should be set up for the conventionally unlimited period, provide system and various finance support to residents , be integrated into space of digital economy, realize its own education programs of different profile and have a preventive model of management. Business-incubator is considered in two aspects. In a wider sense it is a specialized social and economic institution oriented to provision of long-term rise in intensity and finance and economic efficiency of entrepreneurial activity at the expense of favorable conditions for locating potentially competitive businessstructures at the initial stage of their life cycles on special territories. In the narrower sense business-incubator is an entity of territorial (federal, regional or municipal) system of supporting entrepreneurial initiatives, which could ensure their progressive development at the expense of providing production, technological, finance, information, consultative and other resources on preference or free of charge basis.
Small Molecule Antagonists Targeting Growth Factors/Receptors
Authors: Yang Dajun , Wang Shaomeng 
Published: October 2022

Abstract:
Control of cell proliferation is regulated by interaction of soluble growth factors and cell membrane receptors. Studies of growth factors and their receptors provide a new approach to elucidate mechanisms of cancer progression, and more importantly, a unique potential for development of targeted anticancer therapy. A growth factor (ligand) binding to its receptor(s) triggers a complex series of intracellular signaling pathways th_at may culminate in a change in cell behavior. Considerable number of studies indicate that the inappropriate expression and/or activation of the growth factor/receptors can mediate abnormal cellular signaling and oncogenic transformation both in vitro and in vivo system. These results strongly support the hypothesis that growth factors/receptors plays an important role in the tumorigenesis of cancer.
A number of families of structurally related growth factors and receptors have been identified and were considered as potential targets for specific antitumor therapy. This review will focus on recent advances in drug discovery that have identified small organic molecules that affect ligand binding, kinase activity, and signaling transduction and alter cell function. Recent progress of small molecule-based drug discovery targeting several growth factor/receptor families is presented. Approach utilizing computer based 3D pharmacophore searches is discussed. These approaches to develop novel anticancer therapies focus on mechanisms different from conventional chemotherapeutic and radiotherapeutic regimens. These targeted anticancer therapies may be highly tumor cell specific, since they do not require host accessory factors. Furthermore, these potential small molecule drugs may have the capacity to synergistically or additively improve the presently available hormonal, radiation or chemotherapy of cancer.
Low– and Medium–Socioeconomic-Status Group Members’ Perceived Challenges and Solutions for Healthy Nutrition: Qualitative Focus Group Study
Authors: Hermsen Sander , van Kraaij Alex , Camps Guido 
Published: October 2022

Background
Although digital tools for healthy nutrition have shown great potential, their actual impact remains variable as digital solutions often do not fit users’ needs and barriers. This is especially poignant for priority communities in society. Involving these groups in citizen science may have great benefits even beyond the increase in knowledge of the lives and experiences of these groups. However, this requires specialized skills. Participants from priority groups could benefit from an approach that offers sensitization and discussion to help them voice their needs regarding healthy nutrition and technology to support healthy eating.

Objective
This study aimed to gather insights into people’s thoughts on everyday eating practices, self-regulation in healthy eating, and skill acquisition and on applying technological innovations to these domains.

Methods
Participants answered 3 daily questionnaires to garner their current practices regarding habits, self-regulation, skills, and technology use surrounding healthy eating and make it easier for them to collect their thoughts and experiences (sensitization). Within a week of filling out the 3 questionnaires, participants took part in a web-based focus group discussion session. All sessions were transcribed and analyzed using a thematic qualitative approach.

Results
A total of 42 people took part in 7 focus group interviews of 6 people each. The analysis showed that participants would like to receive support from technology for a broad range of aspects of nutrition, such as measuring the effect their personal nutrition has on their individual health, providing them with reliable product information, giving them practical guidance for healthy eating and snacking, and reducing the burden of registering food intake. Technology should be easy to use, reduce burdens, and be tailored to personal situations. Privacy and cost were major concerns for the participants.

Conclusions
This study shows that people from low– and medium–socioeconomic-status groups have a need for specific support in tailoring their knowledge of healthy nutrition to their own situation and see technology as a means to achieve this.
A Novel Concentrated, Interdisciplinary Group Rehabilitation Program for Patients With Chronic Obstructive Pulmonary Disease: Protocol for a Nonrandomized Clinical Intervention Study
Authors: Frisk Bente , Njøten Kiri Lovise , Aarli Bernt , Hystad Sigurd William , Rykken Sidsel , Kjosås Ane , Søfteland Eirik , Kvale Gerd 
Published: October 2022

Background
Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and innovative rehabilitation models are highly warranted. Recently, the group behind the present study published a protocol describing a novel concentrated, interdisciplinary group rehabilitation program for patients with chronic illnesses. The current paper describes an extension of this protocol to patients with COPD.

Objective
The objective of this study is to explore the acceptability of concentrated, interdisciplinary group pulmonary rehabilitation for patients with COPD. The intervention is expected to improve functional status and be highly acceptable to patients.

Methods
This study will include 50 patients aged over 40 years who fulfill the diagnostic criteria for COPD: a forced expiratory volume at the first second (FEV1) <80% of expected and a FEV1/forced vital capacity ratio below the lower limit of normal according to the Global Lung Function Initiative. An interdisciplinary team consisting of physicians, physiotherapists, psychologists, pharmacists, clinical nutritionists, and nurses will deliver the treatment to groups of 6 to 10 patients over 3 to 4 consecutive days with a 12-month follow-up. The intervention is divided into three distinct phases: (1) pretreatment preparation for change, (2) concentrated rehabilitation, where the patient is coached to focus on making health-promoting microchoices, and (3) integration of the changes into everyday living, aided by digital follow-up and 2 on-site clinical examinations. Statistical significance will be set at α=.05.

Results
The recruitment period will last from April 2022 until June 2023.

Conclusions
If successful, this highly novel rehabilitation format might change the way we deliver care for patients with COPD, leading to substantial societal and socioeconomic gains. The study will expand knowledge on the concentrated treatment format as a rehabilitation model for people with COPD.

Trial Registration
ClinicalTrials.gov NCT05234281; https://clinicaltrials.gov/ct2/show/NCT05234281

International Registered Report Identifier (IRRID)
PRR1-10.2196/40700
Researches of the pre-evacuation time of people in residential multi-storey buildings without fire warning systems
Authors: Samoshin D. A. , Istratov R. N. , Sharanova M. M. , Kochetygov V. A. , Tomin S. V. , Frolov A. G. 
Published: October 2022

Introduction. According to statistics, the greatest loss of life from fires in Russia occurs in residential buildings with a height up to 28 m. At the same time, most fire protection systems are not provided in such type of buildings. In particular, in residential buildings of mentioned above height fire alarm system maybe not. That is why the real values of the pre-evacuation time (PET) in the buildings are not known, because domestic research still has not been conducted.Goals and objectives. The aim of the work was to establish the values of the PET of people in a residential building that is not equipped with a fire alarm system.The main tasks were to study the time to warn building occupants about a fire and to research the time of people’s reaction to a fire warning.Methods. The method of scientific research in this work is a full-scale experiment. In the first set of experiments focus were on warning time — it was investigated how much time it took to warn all building occupants by 1, 2 and 3 notifiers. The second set of experiments were aimed to study of people’s reaction time to a fire alarm — it was determined how long it took to start evacuating from their apartments.Results and their discussion. Studies have shown that the value of the alert time of a nine-storey building by one, two and three notifiers averaged was 20.0, 11.6 and 7.2 min, respectively. Based on the data obtained, a mathematical model was built that allows predicting the optimal number of notifiers depending on the number of storeys in the building. Studies of people’s reaction time to a fire alarm have shown that during the daytime, on average, people need less time to realize and prepare for evacuation (72 s) than at night (112 s). Combining the results obtained allowed us to determine the optimal number of notifiers to warn all people in residential building.Conclusion. Comparison of the experimental values of the PET with the data of the current Methodology of fire risk calculation for a nine-storey house showed a discrepancy of 2.6 times.
Effect of computational grid cell size and heterogeneity of computing area for estimated fire detection time
Authors: Kalmykov S. P. 
Published: October 2022

Introduction. In Russia, based on the provisions of the current regulatory documents, the time for the start of evacuation for a room in which a fire broke out is determined depending on the area of the room. According to some authors, the time of the start of the evacuation of people is a combination of “technical”, which includes the time of detection of a fire, and “psychophysical”, determined by the behavioral and organizational characteristics of the people who make it up. The fire detection time is currently not taken into account.Purpose. Evaluation of the influence of the size of the cells of the computational grid and the inhomogeneity of the computational domain on the estimated time of fire detection.Aims. 1. Establish the qualitative nature of the influence of the size of the cells of the computational grid and the inhomogeneity of the computational domain on the estimated time of fire detection.2. Offer recommendations for determining the estimated time of fire detection.Methods. For research, computer simulation methods were used using the Fire Dynamics Simulator software package.Results and discussion. The use of grids with different cell sizes can significantly reduce the number of cells in the computational domain and, as a result, the computation time. However, this leads to rather contradictory results. The minimum time values are reduced by almost 3–4 times compared to a homogeneous computational grid, and the maximum time increases by 2 times.Conclusions. 1. The size of the cells of the computational grid and the inhomogeneity of the computational domain have a significant impact on the time of fire detection.2. A sufficiently large spread in the values of the estimated fire detection time may indicate an unreliable estimate of the total time for the start of evacuation and incorrect conclusions about the safe evacuation of people and/or the probability of evacuation of people.3. For a correct estimate of the evacuation start time, taken into account the estimated fire detection time, it is recommended to use homogeneous computational grids with cell sizes not exceeding 0.25 m.
Listening and Mediation: of agency and performative responsivity in ecological sound art practices
Authors: Halla Steinunn Stefánsdóttir  , Stefan Östersjö  
Published: October 2022

Published as part of: Halla Steinunn Stefánsdóttir and Stefan Östersjö, ‘Listening and Mediation: of agency and performative responsivity in ecological sound art practices’ in ‘Practices of Phenomenological and Artistic Research’, (eds.) Alex Arteaga, Emma Cocker, Erika Goble, Juha Himanka, Phenomenology & Practice, Volume 17 (2022), No.1, ISSN 1913-4711. See here: https://journals.library.ualberta.ca/pandpr/index.php/pandpr/index
8-year outcomes of aortic valve replacement with the Carpentier-Edwards PERIMOUNT Magna Ease valve
Authors: Tsui Steven , Rosenbloom Michael , Abel James , Swanson Jeffrey , Haverich Axel , Zacharias Joseph , Schorlemmer Gilbert , Cohen Gideon , Moulton Michael , Lange Ruediger 
Published: October 2022

Introduction The Carpentier-Edwards PERIMOUNT Magna Ease valve
is a third-generation bioprosthesis for aortic valve replacement (AVR).
This is a postapproval study reporting on its 8‑year outcomes.
Methods Adults undergoing AVR with the Magna Ease valve between
October 2007 and December 2012 were enrolled for this prospective,
nonrandomized, single‑arm, multicenter study. Assessments occurred
preoperatively, at hospital discharge, 6 months, 1 year, and annually
thereafter up to 8 years. Outcomes included safety endpoints,
hemodynamic performance, and New York Heart Association (NYHA)
Functional Class. Results Of the 258 study patients, 67.5%
were in NYHA Class I or II, and 32.5% were in NYHA Class III or IV at
baseline. Concomitant procedures were performed in 44.2%. Total
follow-up was 1,597.6 patient-years, median follow‑up was 7 years
(interquartile range: 5.5–8.0 years). Eight years following AVR,
functional class remained improved from baseline with 93.9% in NYHA
Class I/II and 6.1% in NYHA Class III; thirty-eight deaths had
occurred, eight of which were valve related; freedom from all‑cause
mortality was 80.7% (95% confidence intervals 74.9, 86.4); freedom
from valve-related mortality was 95.8% (92.8, 98.8); freedom from
reintervention, explant, major bleeding events, and structural valve
deterioration were 89.8% (85.1, 94.6), 94.8% (91.7, 97.9), 85.1%
(80.0, 90.1), and 90.1% (84.7, 95.4), respectively; effective orifice
area was 1.5±0.5 cm , mean gradient was 14.8±8.3
mmHg, and 88.6% of patients had no or trivial aortic regurgitation.
Conclusions This study demonstrated satisfactory safety and
sustained hemodynamic and functional improvements at 8 years following
AVR with the Magna Ease valve.
Politizar el recuerdo: la experiencia de perder un hijo por “gatillo fácil” en Córdoba, Argentina
Authors: Bonvillani Andrea 
Published: October 2022

El propósito de este trabajo es dar cuenta del registro subjetivo de la experiencia de profundo dolor de madres de jóvenes asesinados por la policía de la Provincia de Córdoba (Argentina), mediante el análisis de entrevistas e intervenciones públicas de un grupo de mujeres que han padecido esta pérdida en condiciones extremas. Uno de los ejes que emergen de este estudio lo denomino politización del recuerdo: consiste en mantener viva la memoria de la vida del hijo-muerto, oponiendo una narrativa reivindicatoria frente a la construcción de la opinión pública, agenciada en particular por los medios hegemónicos, que los construyen como delincuentes merecedores de ese final y, por ende, justifican estas prácticas policiales. Este aspecto supone una lucha en el plano simbólico en términos de reconocimiento y respeto, con consecuencias en la dimensión jurídica, al constituirlo en un hecho judiciable.

Palabras clave: politizar el recuerdo; gatillo fácil; madres; jóvenes; Argentina
Influence analysis of piano music immersion virtual reality cooperation based on mapping equation
Authors: Wang Minju 
Published: October 2022

Abstract
In order to explore the influence of piano music immersive virtual reality cooperation, a method of VR image recognition based on mapping equation is proposed. Firstly, through the feature extraction of the image, the main color of the target image is obtained, and the extracted results are smoothed. Through the two steps of color space conversion and tone reverse mapping, the morphological transformation of the image is realized to obtain the transition image. The K-means clustering matching operation is performed on the transition image, and the optimal energy equation of color migration is obtained by hierarchical migration and global migration. The reverse mapping color migration algorithm is put into the virtual reality technology. A virtual piano is developed with HTC Vive suite and Leap Motion sensor fixed on the helmet as the hardware platform, and Unity3D and related StreamVR plug-ins and Leap Motion plug-ins as the software platform. The virtual piano forms a virtual keyboard with a cube component. By compiling the script response function of the cube component being approached and pressed or released, the performance events of the virtual piano keyboard are recorded, and the sound of the virtual piano is further realized with the help of MIDI. The experimental results show that 400 groups of data are collected for the four gesture movements, of which 300 groups are used for training modeling and 100 groups for recognition. The gesture recognition results based on HMM are shown in figure 3, and the visible recognition rate can reach more than 88%. It is proved that the immersion of 3D virtual piano is much higher than that of 2D virtual piano displayed on ordinary computer screen; Moreover, it can be played naturally with both hands, and the sense of comfort and fluency is much stronger than the 2D virtual piano played with the help of mouse and keyboard.
Influence of direct-fed microbial blend and Ferula elaeochytris on in vitro rumen fermentation pattern and degradability during simulated ruminal acidosis
Authors: Sizmaz Ozge , Mickdam Elsayed , Eren Gultepe Eyüp 
Published: October 2022

Abstract

Introduction
The use of probiotics and phytobiotics has attracted interest because of their protective effect against acidosis. Ferula elaeochytris (FE) is considered a good source of bioactive compounds, mainly monoterpene α-pinene. This study aimed to investigate the effect of a direct-fed microbial blend (Pro) and FE on rumen fermentation parameters in vitro under normal and acidosis conditions.

Material and Methods
An in vitro experiment using the Hohenheimer Futterwerttest (HFT) gas production system was conducted. An acidosis challenge was made to compare the effectiveness of the probiotics blend and FE extract on ruminal pH regulation. To generate different ruminal fermentation parameters, the design of the trial considered the 2 additives (Pro and FE) × 6 incubation times (2, 4, 8, 12, 24 and 48 h) × 2 conditions (acidosis and normal) × 2 incubation runs for each feedstuff (barley, alfalfa and straw).

Results
An acidosis challenge was successfully induced. The Pro and FE additives had no impact on the observed rumen fermentation parameters such as volatile fatty acid concentration or ammonia (P = 0.001). The acidosis condition decreased total in vitro degradability (IVD) by 3.5% and 21.9% for barley and straw, respectively (P < 0.001). The additives had different significant effects on the IVD of nutrients during both normal and acidosis conditions. In alfalfa samples, FE supplementation significantly decreased the IVD of all observed nutrients under the ruminal acidosis condition, although it had no effect during the normal condition.

Conclusion
An acidosis challenge was successfully induced and the effect of additives was varied on fermentation parameters and rumen degradability of different feeds either under normal or acidosis conditions.
Tropical Materialisms: Toward Decolonial Poetics, Practices and Possibilities
Authors: Benitez Christian Jil R. , Lundberg Anita 
Published: October 2022

Tropical Materialisms concur on at least three things: humans are always entangled with non-human/material agents; such entanglement is necessary for any creative act to take place; and these same entanglements allow us to interrogate and re-evaluate preconceived notions about the world. This Special Issue aligns itself with the fields of new materialism and posthumanism. What is particularly exciting is the opportunity to rearticulate these fields in tropical terms, that is, with scholarly and creative practices from and about the tropical world. This focus is crucial given that current scholarship in new materialism and posthumanism predominantly comes from European temperate contexts and is informed by Western philosophies. In order to decolonize the ontological turn, this Special Issue recognises not only that colonial knowledge systems impacted the tropics, but also that matter’s liveliness was and is well understood in Indigenous cosmologies, ancient philosophies and ‘animist materialism’. The papers collected together in this special issue offers materialisms informed by decolonizing intuitions. They variously demonstrate how the tropics, as geographic zone and as pertaining to poetics (via "tropes"), can theoretically inform and historically problematise new materialism and posthumanism. They offer new vocabularies through which discourses on "tropical materialism" may be initiated; and a cartography of practices across disciplinary fields which demonstrate what this "tropical materialism" may be. The Special Issue collection it itself a form of poiesis: a creative engagement with the world.