bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using deep learning to distinguish malignant from benign parotid tumors on plain computed tomography images
Authors: Hu Ziyang , Wang Baixin , Pan Xiao , Cao Dantong , Gao Antian , Yang Xudong , Chen Ying , Lin Zitong 
Published: August 2022

ObjectivesEvaluating the diagnostic efficiency of deep-learning models to distinguish malignant from benign parotid tumors on plain computed tomography (CT) images.Materials and methodsThe CT images of 283 patients with parotid tumors were enrolled and analyzed retrospectively. Of them, 150 were benign and 133 were malignant according to pathology results. A total of 917 regions of interest of parotid tumors were cropped (456 benign and 461 malignant). Three deep-learning networks (ResNet50, VGG16_bn, and DenseNet169) were used for diagnosis (approximately 3:1 for training and testing). The diagnostic efficiencies (accuracy, sensitivity, specificity, and area under the curve [AUC]) of three networks were calculated and compared based on the 917 images. To simulate the process of human diagnosis, a voting model was developed at the end of the networks and the 283 tumors were classified as benign or malignant. Meanwhile, 917 tumor images were classified by two radiologists (A and B) and original CT images were classified by radiologist B. The diagnostic efficiencies of the three deep-learning network models (after voting) and the two radiologists were calculated.ResultsFor the 917 CT images, ResNet50 presented high accuracy and sensitivity for diagnosing malignant parotid tumors; the accuracy, sensitivity, specificity, and AUC were 90.8%, 91.3%, 90.4%, and 0.96, respectively. For the 283 tumors, the accuracy, sensitivity, and specificity of ResNet50 (after voting) were 92.3%, 93.5% and 91.2%, respectively.ConclusionResNet50 presented high sensitivity in distinguishing malignant from benign parotid tumors on plain CT images; this made it a promising auxiliary diagnostic method to screen malignant parotid tumors.
Systemic Lupus Erythematosus Presenting With Thrombotic Thrombocytopenic Purpura at Onset: A Case Report
Authors: Takagi Yoko , Kobayashi Yasuko , Hirakata Ayako , Takei Mariko , Ogasawara Satoshi , Yajima Chikage , Ikeuchi Yuka , Matsumoto Akira , Ogawa Yoshiyuki , Handa Hiroshi , Matsumoto Masanori , Arakawa Hirokazu , Takizawa Takumi 
Published: August 2022

BackgroundThrombotic microangiopathy (TMA) is a syndrome associated with hemolytic anemia, thrombocytopenia, and various organ disorders. Thrombotic thrombocytopenic purpura (TTP) is a disease that develops when a disintegrin-like and metalloproteinase with thrombospondin type l motif 13 (ADAMTS13) activity decreases to &lt; 10% of that in normal plasma, causing platelet thrombosis in microvessels throughout the body. Currently, ADAMTS13-deficient TMA is diagnosed as TTP. Systemic lupus erythematosus (SLE)-related TMA includes both acquired TTP, in which ADAMTS13 activity is significantly reduced, and secondary TMA, in which ADAMTS13 activity is not reduced. Both diseases have different prognoses.Case PresentationAn 11-year-old girl was admitted to our hospital on suspicion of TMA with thrombocytopenia and hemolytic anemia. Because the patient had hypocomplementemia, SLE-related TMA or complement-related TMA was considered. Therefore, we initiated plasma exchange (PE) for the patient. Subsequently, she fulfilled the pediatric SLE diagnostic criteria, and ADAMTS13 activity was shown to be decreased and the anti-ADAMTS13 antibody titer increased. She was thus diagnosed with acquired TTP caused by SLE. Treatment response was good as a platelet count and ADAMTS13 activity improved with three times of PE, followed by methylprednisolone pulse therapy and administration of mycophenolate mofetil. Renal pathology showed thrombus formation in glomerular arterioles and lupus nephritis categorized as Class III (A) of the International Society of Nephrology and the Renal Pathology Society classification. Because the patient was thought to be in the high-risk group of SLE, three courses of intravenous cyclophosphamide pulse therapy were administered as an additional induction therapy. No recurrence of TTP was observed.ConclusionIn SLE-related TMA, measurement of ADAMTS13 activity and the anti-ADAMTS13 antibody titer are necessary for diagnosis, and for predicting prognosis and recurrence of the disease; however, in the acute phase of immune-mediated TMA, it is important to initiate proper treatments even before knowing the results to improve prognosis.
Case Report: Good cardiac tolerance to Toripalimab in a CVD patient with oral melanoma
Authors: Pan Wei , Yin Li , Guo Yadi , Pan Dachao , Huang Hui 
Published: August 2022

Primary oral melanoma is extremely rare, and the prognosis is very poor. With the development of immunotherapy, melanoma’s treatment landscape changed dramatically. Toripalimab, a recombinant programmed death receptor 1 (PD-1) monoclonal antibody, has been approved as second-line therapy for metastatic melanoma. However, the cardiac toxicity of Toripalimab is seldom reported. This article describes the application of Toripalimab on a patient who suffered from primary oral melanoma accompanied with arrhythmic mitral valve prolapse (AMVP).Case Summary: A 55-year-old Chinese female was diagnosed with BRAF wild-type oral malignant melanoma by excisional biopsy and genetic test. The melanoma quickly progressed after complete tumor resection. Combined therapy after surgical resection was applied to control the progression of melanoma. Due to this patient’s basic cardiovascular situation, sacubitril–valsartan, spironolactone, and bisoprolol were used to maintain cardiac function. After five antitumor treatment courses, we re-evaluated the patient systemically from the symptom, physical examination, and auxiliary examination. The result showed that the patient who received Toripalimab combined with chemotherapy and radiotherapy did not present severe side effects on the cardiovascular system. The cardiac function remained well.Conclusions: This case provided evidence of Toripalimab combined with chemotherapy on melanoma patients with complex cardiovascular diseases. Toripalimab demonstrated a manageable safety profile and durable clinical response. In addition, the standard CHF treatment plays a vital role in the protection of cardiac function. In a cancer patient with complex cardiovascular diseases, standard prophylactic CHF treatment should be applied at an early stage.
Active coping strategies and less pre-pandemic alcohol use relate to college student mental health during the COVID-19 pandemic
Authors: Akeman Elisabeth , Cannon Mallory J. , Kirlic Namik , Cosgrove Kelly T. , DeVille Danielle C. , McDermott Timothy J. , White Evan J. , Cohen Zsofia P. , Forthman K. L. , Paulus Martin P. , Aupperle Robin L. 
Published: August 2022

ObjectiveTo further delineate risk and resilience factors contributing to trajectories of mental health symptoms experienced by college students through the pandemic.Participantsn = 183 college students (67.2% female).MethodsLinear mixed models examined time effects on depression and anxiety. Propensity-matched subgroups exhibiting “increased” versus “low and stable” depression symptoms from before to after the pandemic-onset were compared on pre-pandemic demographic and psychological factors and COVID-related experiences and coping strategies.ResultsStudents experienced worsening of mental health symptoms throughout the pandemic, particularly during Fall 2020 compared with Fall 2019 (Depression scale d = −0.43 [95% CI: −0.65 to −0.21]). The propensity-matched subgroup exhibiting relative resilience (“low and stable” symptoms) reported less alcohol use prior to the pandemic, greater use of active coping strategies, and less of an impact on their college progress.ConclusionsResults point to several potential targets of screening and intervention to decrease residual impacts of the pandemic.
Vaccination coverage of patients with type 2 diabetes mellitus: Challenging issues from an outpatient secondary care setting in Greece
Authors: Galanos Georgios , Dimitriou Helen , Pappas Angelos , Perdikogianni Chrysoula , Symvoulakis Emmanouil K. , Galanakis Emmanouil , Lionis Christos 
Published: August 2022

BackgroundIncreased morbidity/mortality due to vaccine preventable diseases (VPD) is encountered in type 2 diabetes (T2D) people. Aim of this study was to assess their vaccination coverage and describe trends possibly affecting compliance.MethodsInformation on vaccination coverage was retrieved from either documents or interview provided by patients, and/or their vaccination record card at a specialized outpatient diabetes center. The selection of the patients was arbitrary.ResultsAn increasing vaccination rate for influenza was observed from 2018 to 2020 among 372 participants. The vaccination coverage for S.pneumoniae was 67.2% (PCV13), 20.4% (PPSV23), 26.3% for herpes zoster in individuals ≥60 years, 1.9% for tetanus-diphtheria-pertussis and 1.1% for hepatitis B. A 10.2% of participants were found to be unvaccinated. Vaccination uptake for influenza and PCV13 was related to age, ≥3 comorbidities and long-term follow-up. T2D individuals consecutively vaccinated for influenza were 3.78 times more likely to be also vaccinated with PCV13.ConclusionsVaccination rates of patients with T2D show an increasing trend, especially for influenza and S. pneumoniae, although the one for S. pneumoniae was low. Older people seem more prone to vaccination, the one for herpes zoster was low with infected patients remaining unvaccinated while significantly low coverage was observed for other VPDs. The findings are important to improve effectiveness of preventative services.
A bibliometric analysis of research on craniomaxillofacial distraction osteogenesis from 2000 to 2021
Authors: Liu Zhen , Yang Jianying , Zhou Changhan , Liu Yao , Luo En 
Published: August 2022

ObjectiveThis study collected and summarized publications related to craniomaxillofacial distraction osteogenesis(DO) from 2000 to 2021, investigated trends in related research, and compared publications from different countries, institutions and journals. The aim is showcasing hotspots and frontiers in the field and providing a reference for future research.BackgroundCraniomaxillofacial DO serves to treat different types of craniomaxillofacial dysplasia and bone defects and deformities. DO can significantly reduce surgical trauma, complications, and recurrence rate compared to conventional surgery. However, there is a lack of bibliometric analyses regarding Craniomaxillofacial DO.MethodsCiteSpace and VOSviewer were used to analyze and visualize 3,141 articles and reviews searching through the Web of Science Core Collection(WOSCC) to obtain publications on craniomaxillofacial DO from 1 January 2000 to 31 December 2021.ResultsIn the last 21 years, there has been a significant increase in the number of publications. The United States, the People's Republic of China, and Italy produce the vast majority of publications. University of Milan and University of Bologna are the most influential in this field. McCarthy JG is the most influential author. Obstructive sleep apnea, TMJ ankylosis and cleft lip and palate are potential research direction in this field.ConclusionFuture research should focus on the precise indications and optimal timing of craniomaxillofacial DO and the evaluation of the long-term outcomes of various modified procedures. This study provides a relatively objective reference for related researchers, medical practitioners, and global health systems.
Critical view of safety in laparoscopic cholecystectomy: A prospective investigation from both cognitive and executive aspects
Authors: Jin Yi , Liu Runwen , Chen Yonghua , Liu Jie , Zhao Ying , Wei Ailin , Li Yichuan , Li Hai , Xu Jun , Wang Xin , Li Ang 
Published: August 2022

BackgroundThe achievement rate of the critical view of safety during laparoscopic cholecystectomy is much lower than expected. This original study aims to investigate and analyze factors associated with a low critical view of safety achievement.Materials and MethodsWe prospectively collected laparoscopic cholecystectomy videos performed from September 2, 2021, to September 19, 2021, in Sichuan Province, China. The artificial intelligence system, SurgSmart, analyzed videos under the necessary corrections undergone by expert surgeons. Also, we distributed questionnaires to surgeons and analyzed them along with surgical videos simultaneously.ResultsWe collected 169 laparoscopic cholecystectomy surgical videos undergone by 124 surgeons, among which 105 participants gave valid answers to the questionnaire. Excluding those who conducted the bail-out process directly, the overall critical view of safety achievement rates for non-inflammatory and inflammatory groups were 18.18% (18/99) and 9.84% (6/61), respectively. Although 80.95% (85/105) of the surgeons understood the basic concept of the critical view of safety, only 4.76% (5/105) of the respondents commanded all three criteria in an error-free way. Multivariate logistic regression results showed that an unconventional surgical workflow (OR:12.372, P &lt; 0.001), a misunderstanding of the 2nd (OR: 8.917, P &lt; 0.05) and 3rd (OR:8.206, P &lt; 0.05) criterion of the critical view of safety, and the don't mistake “fundus-first technique” as one criterion of the critical view of safety (OR:0.123, P &lt; 0.01) were associated with lower and higher achievements of the critical view of safety, respectively.ConclusionsThe execution and cognition of the critical view of safety are deficient, especially the latter one. Thus, increasing the critical view of safety surgical awareness may effectively improve its achievement rate.
Diversity and Distribution of Calonectria Species from Plantation and Forest Soils in Fujian Province, China
Authors: Liu Qianli , Wingfield Michael J. , Duong Tuan A. , Wingfield Brenda D. , Chen Shuaifei 
Published: August 2022

To meet the growing demand for wood and pulp products, Eucalyptus plantations have expanded rapidly during the past two decades, becoming an integral part of the southern China landscape. Leaf blight caused by various Calonectria spp., is a serious threat to these plantations. In order to explore the diversity and distribution of Calonectria spp. in Fujian Province soils, samples were collected in Eucalyptus plantations and adjacent plantings of Cunninghamia lanceolata, Phyllostachys heterocycle and Pinus massoniana as well as in natural forests. Three hundred and fifty-three Calonectria isolates were recovered from soil samples and they were identified based on a comparison of multilocus DNA sequence data for the act (actin), cmdA (calmodulin), his3 (histone H3), rpb2 (the second largest subunit of RNA polymerase), tef1 (translation elongation factor 1-alpha) and tub2 (β-tubulin) gene regions, as well as morphological characteristics. Six known taxa including Calonectria aconidialis, Ca. hongkongensis, Ca. ilicicola, Ca. kyotensis, Ca. pacifica, Ca. pseudoreteaudii and one novel species described here as Ca. minensis sp. nov. were identified. Of these, Ca. aconidialis and Ca. kyotensis were the most prevalent species, and found in eight and seven sites, and four and five forest types, respectively. Calonectria spp. were most abundant in soils from Eucalyptus stands, followed by P. heterocycle and natural forests. Relatively few species were found in the soils associated with Cunninghamia lanceolata and Pinus massoniana. The abundance of known Calonectria spp. suggests that these fungi have been relatively well sampled in Fujian. The results are also consistent with the fact that most Calonectria diseases are found on Angiosperm as opposed to Gymnosperm plants.
Corrosion Inhibition of Mild Steel in Hydrochloric Acid Environment Using Terephthaldehyde Based on Schiff Base: Gravimetric, Thermodynamic, and Computational Studies
Authors: Mahdi Bahaa Sami , Abbass Muna Khethier , Mohsin Mustafa Khudhair , Al-azzawi Waleed Khalid , Hanoon Mahdi M. , Al-kaabi Mohammed Hliyil Hafiz , Shaker Lina M. , Al-amiery Ahmed A. , Isahak Wan Nor Roslam Wan , Kadhum Abdul Amir H. , Takriff Mohd S. 
Published: August 2022

Using traditional weight-loss tests, as well as different electrochemical techniques (potentiodynamic polarization and electrochemical impedance spectroscopy), we investigated the corrosion-inhibition performance of 2,2′-(1,4-phenylenebis(methanylylidene)) bis(N-(3-methoxyphenyl) hydrazinecarbothioamide) (PMBMH) as an inhibitor for mild steel in a 1 M hydrochloric acid solution. The maximum protection efficacy of 0.0005 M of PMBMH was 95%. Due to the creation of a protective adsorption layer instead of the adsorbed H2O molecules and acidic chloride ions, the existence of the investigated inhibitor reduced the corrosion rate and increased the inhibitory efficacy. The inhibition efficiency increased as the inhibitor concentration increased, but it decreased as the temperature increased. The PMBMH adsorption mode followed the Langmuir adsorption isotherm, with high adsorption-inhibition activity. Furthermore, the value of the ∆Gadso indicated that PMBMH contributed to the physical and chemical adsorption onto the mild-steel surface. Moreover, density functional theory (DFT) helped in the calculation of the quantum chemical parameters for finding the correlation between the inhibition activity and the molecular structure. The experimental and theoretical findings in this investigation are in good agreement.
Aquaponia: um exemplo pioneiro de inclusão formal de Educação Ambiental no sistema educativo português
Authors: Martins Pedro 
Published: August 2022

A Educação Ambiental (EA) em Portugal é abordada sobretudo de maneira informal. Este projeto pretendeu incluir formalmente um conceito relacionado com a EA no currículo de um curso profissional. O conceito escolhido foi a Aquaponia (criação em circuito fechado de peixes e de plantas) devido às características e valia técnica do mesmo. O projeto durou três anos, durante os quais se deu formação aos professores envolvidos. Realizaram-se inquéritos por questionário aos alunos e entrevistas aos professores, cuja análise de conteúdo permitiu solucionar alguns problemas iniciais. Desta forma, atendeu-se à necessidade de dar respostas à crise ambiental global atuando localmente no currículo, enquanto mediador entre escola e sociedade.
Potensi Metode Sonic Bloom untuk Meningkatkan Pertumbuhan Tanaman
Authors: Nio Song Ai , Rumbay Julia Angel , Anggini Putri Sri , Supit Patrycia Saskia Laurita , Ludong Daniel Peter Mantilen 
Published: August 2022

Metode sonic bloom merupakan pengembangan ilmu pengetahuan dan teknologi di bidang pertanian yang memanfaatkan gelombang suara dengan frekuensi tinggi tanpa merusak lingkungan. Aplikasi sonic bloom berpotensi untuk meningkatkan pertumbuhan pada tanaman yang ditunjukkan dengan adanya peningkatan pembukaan stomata, perkecambahan, pertumbuhan (tinggi tanaman, tinggi dan diameter batang, panjang dan lebar daun, dan panjang akar) serta produktivitas. Metode sonic bloom yang efektif menggunakan bunyi dengan rata-rata intensitas bunyi 65-75 dB, frekuensi bunyi 3-5 kHz dan lama pemaparan 3 jam per hari serta variasi jenis musik. Gelombang bunyi ini menginduksi pembukaan stomata yang berdampak pada peningkatan penyerapan CO2, H2O dan unsur-unsur hara oleh tanamanThe sonic bloom method is the development of science and technology in agriculture that utilizes high-frequency sound waves without damaging the environment. Sonic bloom application was potential to increase plant growth as indicated by an increase in stomata opening, germination, growth (plant height, height and diameter of stem, length and width of leaf, and root length) and productivity. An effective sonic bloom method used sound with an average sound intensity of 65-75 dB, a sound frequency of 3-5 kHz and an exposure time of 3 hours per day as well as a variety of types of music. This sound wave induced the opening of stomata which had an impact on increasing the absorption of CO2, H2O and nutrients by plants.
Eksplorasi model lingkar operasional pukat cincin KM. Velita di Perairan Manado Tua
Authors: Tangdipau Anggriani , Silooy Fanny 
Published: August 2022

Pukat cincin merupakan alat tangkap ikan yang efektif menangkap ikan-ikan pelagis. Untuk menunjang suksesnya operasi penangkapan perlu memperhatikan beberapa faktor pokok seperti: kelajuan melingkari gerombolan ikan, kelajuan tenggelam tali pemberat dan kelajuan menarik tali kolor. Faktor-faktor eksternal oceanografi seperti; arus, gelombang, dan cuaca juga perlu diperhatikan. Tujuan penelitian adalah untuk mengetahui model lingkar operasional pukat cincin KM. Velita, mengetahui kelajuan melingkari gerombolan ikan dan menentukan panjang jaring minimum.Metode yang digunakan adalah metode deskriptif yaitu metode yang digunakan dalam meneliti suatu objek yang tujuannya untuk memberikan gambaran secara sistematis, faktual dan akurat tentang fakta, sifat serta hubungan fenomena dengan visualisasi model lingkaran operasional pukat cincin.Pukat cincin KM Velita memiliki panjang jaring 328 m dan dalam 57,6 m, proses pengoperasiannya dimulai dari penurunan alat tangkap (setting) hingga penarikan alat tangkap (hauling). Alat bantu penangkapan yang digunakan yaitu rumpon, lampu dan winch atau mesin takal. Dapat disimpulkan bahwa 1). model lingkaran jaring saat operasi penangkapan ikan tidak membentuk lingkaran sempurna karena kelajuan melingkar yang kurang dan adanya faktor oseanografi seperti gelombang, arus dan cuaca. 2). Kelajuan melingkari gerombolan ikan pukat cincin KM. Velita adalah 1,28 m/s dan radius melingkar jaring 52,22 m, kelajuan ini terlalu rendah untuk jaring dengan radius tersebut dan 3). Panjang jaring minimum yang sebaiknya digunakan KM. Velita untuk menangkap ikan dengan radius gerombolan ikan 5 m saat operasi dan jarak dari gerombolan ikan 49 m adalah 339,12 m. Untuk panjang jaring yang ada yaitu 328 m maka jarak kapal dari perahu lampu saat mulai operasi adalah 37,22 m, sehingga ikan tidak dapat meloloskan diri.
Keselamatan dan Kesehatan Kerja di Pelabuhan Perikanan Pantai Tumumpa, Manado Sulawesi Utara
Authors: Libuon Asrul , Manoppo Lefrand , Pamikiran Revols D. Ch. , Kaparang Franky E. , Modaso Vivanda O. J. , Luasunaung Alfret 
Published: August 2022

Keselamatan dan Kesehatan Kerja (K3) adalah semua Ilmu dan Penerapannya untuk mencegah terjadinya kecelakaan kerja, penyakit akibat kerja, kebakaran, peledakan dan pencemaran lingkungan. Pelabuhan perikanan adalah sebagai sarana pokok untuk kegiatan usaha penangkapan ikan dan mempunyai peranan yang sangat strategis penting di dalam pengelolaan sumberdaya perikanan tangkap. Penelitian ini bersifat deskriptif yang dimaksudkan untuk mengeksplorasi dan mengklarifikasi terkait aspek keselamatan kerja di pelabuhan perikanan pantai tumumpa.Penelitian ini secara umum bertujuan untuk mengembangkan keselamatan dan kesehatan kerja di pelabuhan perikanan pantai tumumpa; sedangkan secara khusus bertujuan untuk mengetahui ketersedian fasilitas keselamatan dan kesehatan kerja di pelabuhan perikanan pantai tumumpa dan mengetahui prosedur keselamatan dan kesehatan kerja di pelabuhan perikanan pantai tumumpa. Analisis data yang digunakan dari hasil wawancara dirubah secara numerik, cara melakukan perhitungan terhadap data yang diperoleh. Data yang diperoleh dibagi dalam beberapa kriteria dan diberi skor yang selanjutnya disajikan dalam bentuk tabulasi kemudian diinterpretasikan sesuai dengan tujuan.Secara umum dapat dikategorikan pemenuhan fasilitas keselamatan kerja pelabuhan perikanan pantai tumumpa sebagian besar sudah tersdia, tetapi beberapa fasilitas kurang terawat atau tidak tersedia seperti contoh ruangan pertolongan pertama pada kecelakaan. Dalam penelitian diperoleh hasil dari responden syabandar 76% baik, 18% cukup baik, 6% menyatakan kurang sedangkan pada Kapten kapal memiliki hasil respoden 35% dikategorikan baik, 47% cukup baik dan 18% menyatakan kurang, untuk anak buah kapal (ABK) memiliki hasil 9% dikatakan baik, 51% cukup baik dan 40% kurang.