bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Strategy of Bioinformatics Modeling (in silico): Biologically Active Peptides of Milk Protein
Authors: Kruchinin Alexandr , Bolshakova Ekaterina 
Published: April 2022

Bioinformatic analysis methods are an auxiliary tool in the preliminary stage of research into biocatalytic conversion of proteins with predicted release of biologically active peptides. However, there are a number of factors ignored in current strategies for designing biologically active peptides, which prevents the complete prediction of their biological properties. This determines the relevance of the research objective, i.e. developing a hybrid strategy for bioinformatic modeling to study biologically active peptides of milk protein. The new strategy ranks key criteria based on high-performance algorithms of proteomic database.
The research featured the scientific publications on in silico methods applied to biologically active peptides. Modern taxonometric methods of information retrieval were applied using the RSCI, Scopus and Web of Science databases.
The article introduces and describes step by step the optimal in silico hybrid strategy algorithm for studying biologically active milk protein peptides. The algorithm takes into account the safety assessment of all hydrolysis products, their physicochemical and technological properties. The strategy algorithm relies on analytical data on the protein profile, the amino acid sequence of proteins that make up the raw material, taking into account their polymorphism, and the subsequent identification of bioactive amino acid sites in the protein structure. The algorithm selects optimal enzyme preparations, as well as models the hydrolysis and assesses the peptide bioactivity using proteomic databases.
At the preliminary stage of protein hydrolysis, the new in silico strategy scientifically predicts the targeted release of stable peptide complexes of biologically active peptides with proven bioactivity, safety and sensory characteristics. The hybrid algorithm contributes to accumulation of the necessary primary data so as to reduce the time and cost of laboratory experiments.
Effect of Vibration on the Porosity and Strength of Instant Drink Granules
Authors: Popov Anatoliy , Plotnikov Konstantin , Ivanov Pavel , Plotnikov Igor , Popov Dmitry , Plotnikova Irina 
Published: April 2022

Instant food products are extremely popular, and food industry knows numerous ways and methods of their production. To remain competitive, an instant drink production process should be efficient and flawless. The research objective was to improve the physical profile of granular instant products.
The study featured a vibrating drum unit controlled segregated flows. The granulometric composition, porosity, and strength of the obtained granules were tested in a vertical vibration cl assifier.
The new design of the drum with an installed classifier was able to grind larger granules. The research revealed the effect of frequency and amplitude on the porosity and strength of the granules. The rotation rate of the belt mixer had a greater effect on the agglomeration process than the amplitude and frequency of the vibrations in the generator. The porosity and strength of the granules depended on the parameters of the classifier. Therefore, the new drum design made it possible to control the operating parameters depending on the required properties of the finished product. The rational parameters were obtained as follows: frequency and amplitude of the vibration generator – 1 mm and 40 Hz, respectively; rotation speed – 7 rpm; drum tilt angle – 3°; amplitude and frequency of the classifier – 2 mm and 100 Hz, respectively.
The study revealed the optimal technological parameters for a new instant drink. The new vibration classifier increased the distribution density of the granular composition.
Fractionation of Bulk Food Products
Authors: Slavyanskiy Anatoliy , Mitroshina Daria , Gribkova Vera , Karamzin Anatoly 
Published: April 2022

Powders are part of many food products, which makes grinding an important food industry process. The research objective was to develop a new process of separating a polydisperse powder that differs in particle density from the liquid it is dissolved in.
The study featured polydisperse sugar powder crushed in a ball mill and dissolved in sugar wafer suspension. The article introduces a physical and mathematical model of the process and a method for quantitative modeling of the process of separating particles from powder by centrifuging the suspension.
The research was based on the classical concept of the diameter of a particle moving in a predetermined manner in the inter-barrel space of the separator drum. The authors developed a new concept of the current critical particle diameter, which they calculated from the dispersion composition of the powder synthetic indicators, the control parameter of the suspension separation process, and the performance of the separating machine, e.g. coefficients of clarification and loss factor. The study resulted in a new calculation method with fewer fractionation stages.
The authors calculated the separation of targeted particles from a granulometric composition by centrifuging the powder. The calculation method fits any fine and medium-dispersed particle size and can facilitate any quantitative analysis of fractionation processes in a disc separator.
Multi-objective operational optimization toward improved resilience in water distribution systems
Authors: Zhang Chao , Liu Haixing , Pei Shengwei , Zhao Mengke , Zhou Huicheng 
Published: April 2022

AbstractResilience has currently attracted increasing interest in the optimization of water distribution systems (WDSs). Most research mainly focuses on optimal design problems. However, the system operation has not been investigated adequately regarding resilience. Therefore, we proposed an integral format of the demand-weighted modified resilience index (IMRI), which can capture the overall resilient performance throughout the operational period. This indicator was incorporated into the multi-objective operation optimization model as one of the objectives. Two benchmark networks were considered as case studies. The resulting Pareto fronts show a clear competing relationship between cost and resilience. Operating conditions in pumps, reservoirs and tanks at each regulation step were characterized by methods of resilience decomposition, which proved valuable intuitively for resilience regulation. A framework for explicit resilience assessment was also developed to examine directly the overall performance in statistics about those optimal solutions obtained. Explicit resilience results show that the IMRI can effectively quantify the resilience of system operation in the temporal dimension. Furthermore, scheduling more pumps, higher trigger-on levels of tanks and a wider range of trigger-level control could yield a more resilient solution to the operation of WDSs.
Groundwater dynamic influenced by intense anthropogenic activities in a dried-up river oasis of Central Asia
Authors: Wang Wanrui , Chen Yaning , Chen Yapeng , Wang Weihua , Zhang Tianju , Qin Jingxiu 
Published: April 2022

AbstractIntense anthropogenic activities in arid areas have great impacts on groundwater process by causing river dried-up and phreatic decline. Groundwater recharge and discharge have become hot spot in the dried-up river oases of arid regions, but are not well known, challenging water and ecological security. This study applied a stable isotope and end-member mixing analysis method to quantify shallow groundwater sources and interpret groundwater processes using data from 186 water samples in the Wei-Ku Oasis of central Asia. Results showed that shallow groundwater (well depth &lt; 20 m) was mainly supplied by surface water and lateral groundwater flow from upstream, accounting for 88 and 12%, respectively, implying surface water was the dominant source. Stable isotopes and TDS showed obviously spatiotemporal dynamic. Shallow groundwater TDS increased from northwest to southeast, while the spatial variation trend of groundwater δ18O was not obvious. Surface water and groundwater in non-flood season had higher values of stable isotopes and TDS than those in flood season. Anthropogenic activities greatly affect groundwater dynamics, where land-cover change and groundwater overexploitation are the main driving factors. The findings would be useful for further understanding groundwater sources and cycling, and help restore groundwater level and desert ecosystem in the arid region.
Improvement in adsorption of Hg2+ from aqueous media using sodium-type fine zeolite grains
Authors: Ogata Fumihiko , Nagai Noriaki , Ito Chihiro , Kobayashi Yuhei , Yamaguchi Mizuki , Tabuchi Ayako , Saenjum Chalermpong , Nakamura Takehiro , Kawasaki Naohito 
Published: April 2022

Abstract
To increase the adsorption capability of Hg2+ from aqueous media, we prepared sodium-type fine zeolite grains with various particle sizes (denoted as ZE1, ZE2 and ZE3). The particle sizes of ZE1, ZE2 and ZE3 were 16.363 ± 0.365, 1.454 ± 0.357 and 0.607 ± 0.377 μm, respectively. Moreover, the CEC, specific surface area and pore volume were in the order ZE1 (42 mmol/g and 23.5 m2/g) &lt; ZE2 (72 mmol/g and 67.1 m2/g) &lt; ZE3 (135 mmol/g and 176.6 m2/g). Subsequently, the Hg2+ adsorption capability was investigated. The performance of tested agents on Hg2+ adsorbed was in the order ZE1 (5.0 mg/g) &lt; ZE2 (9.4 mg/g) &lt; ZE3 (20.2 mg/g). It was concluded that fine crystalline zeolite was important in enhancing the adsorption capability of Hg2+. In addition, the mechanism of adsorption of Hg2+ on the ZE samples was evaluated. Our results suggested that Hg2+ was exchanged with sodium ions in the interlayers of ZE samples with correlation coefficients of 0.966–0.979. Our findings revealed that these ZE samples constitute potential agents for the adsorption of Hg2+ from aqueous media.
Remote magnetic navigation for treatment of patients with atrial fibrillation
Authors: Beloborodov V.V. , Shabanov V.V. , Yelemessov N.A. , Filippenko A.G. , Mikheenko I.L. , Fisher E.V. , Romanov A.B. 
Published: April 2022

Atrial fibrillation (AF) remains an important medical and social health problem occupying a leading position among all cardiac arrhythmias in clinical practice. AF increases overall mortality by 1.9 times and the risk of stroke by 5 times, leads to disability among the working-age population, and reduces the quality of life.
Pulmonary veins isolation is the main approach in the treatment of AF symptomatic patients who are resistant to antiarrhythmic therapy. However, the use of this technique is associated with the need for long-term use of fluoroscopy and monitoring of the contact force of the ablation catheter with the heart tissue for an effective and safe exposure on the arrhythmia substrate. In addition, the complication rate can reach up to 5% even when using non-fluoroscopic navigation systems.
Over the past decade, robotic magnetic navigation was established as a safe and effective technology in the treatment of patients with different cardiac arrhythmias. The advantages of this technology are the flexibility and mobility of the ablation catheter to reach difficult areas during ablation procedure, as well as high efficiency and safety, with a low fluoroscopy exposure time. This review analyses the current literature and documents the experience of using robotic magnetic navigation for the treatment of patients with different forms of AF. We conducted searches on Scopus, Web of Science databases and PubMed.
The reviewed studies demonstrated that the use of robotic magnetic navigation is a safe and highly effective method of treating patients with AF. It also helps to reduce the time of fluoroscopy during ablation procedure.
Received 26 August 2021. Revised 21 September 2021. Accepted 22 September 2021.
Funding: This work was carried out within the framework of the state task of Ministry of Health of Russian Federation No. 121031300225-8.
Conflict of interest: The authors declare no conflict of interest.
Contribution of the authorsConception and study design: V.V. Beloborodov, A.G. Filippenko, A.B. RomanovData collection and analysis: V.V. Beloborodov, N.А. Yelemessov, E.V. Fisher, A.G. Filippenko, V.V. Shabanov, A.B. RomanovStatistical analysis: A.B. Romanov, I.L. MikheenkoDrafting the article: V.V. Beloborodov, A.G. Filippenko, A.B. RomanovCritical revision of the article: A.B. Romanov, I.L. Mikheenko, A.G. Filippenko, V.V. ShabanovFinal approval of the version to be published: V.V. Beloborodov, V.V. Shabanov, N.А. Yelemessov, A.G. Filippenko, I.L. Mikheenko, E.V. Fisher, A.B. Romanov
Evaluation of the effectiveness of interventional treatment of ventricular arrhythmias of rare localizations using non-invasive mapping
Authors: Artyukhina E.A. , Yashkov M.V. , Dedukh E.V. , Taymasova I.A. , Revishvili A.Sh. 
Published: April 2022

Background. Atypical localization of the focus of ventricular arrhythmias is a rather difficult group for invasive mapping and subsequent radiofrequency ablation. Invasive electroanatomical mapping, multipolar electrophysiological electrodes in combination with electrophysiological study for searching an early zone of arrhythmia focus, and substrate mapping, are aimed to identifying critical areas of the arrhythmia contour. However, there are still situations in which arrhythmia cannot be eliminated, despite the use of these systems. The method of superficial non-invasive mapping of the heart seems to be relevant, which makes it possible to estimate the volume of surgery and select the necessary technology to eliminate arrhythmias.Aim. To compare the effectiveness of interventional treatment of patients with ventricular arrhythmias of atypical localization with and without the use of superficial non-invasive mapping.Methods. The study included 40 patients with ventricular arrhythmias of rare localization. The patients were divided into two groups. Group I included 21 patients who underwent non-invasive superficial and invasive electrophysiological cardiac mapping. Group II included 19 patients who underwent invasive electrophysiological cardiac mapping.Results. Over a follow-up period of 12 months, the freedom from arrhythmia in group I was 76%, in group II — 61%. The total operation time, duration and dose of fluoroscopy were less in group I compared to the group II.Conclusion. The study results demonstrated that the method of non-invasive surface mapping of the heart is highly effective in ventricular arrhythmias of atypical localization. The time of radiofrequency ablation, interventional intervention, fluoroscopy is lower with the use of superficial non-invasive mapping, compared with the control group.
Received 13 July 2021. Revised 20 October 2021. Accepted 9 December 2021.
Funding: This work is supported by a grant of the Russian Science Foundation (project No. 19-15-00406).
Conflict of interest: The authors declare no conflict of interest.
Contribution of the authorsConception and study design: E.A. Artyukhina, A.Sh. RevishviliData collection and analysis: E.A. Artyukhina, M.V. Yashkov, E.V. Dedukh, I.A. Taymasova, A.Sh. RevishviliStatistical analysis: M.V. YashkovDrafting the article: E.A. Artyukhina, M.V. YashkovCritical revision of the article: E.A. Artyukhina, M.V. Yashkov, A.Sh. RevishviliFinal approval of the version to be published: E.A. Artyukhina, M.V. Yashkov, E.V. Dedukh, I.A. Taymasova, A.Sh. Revishvili
Patient and Health Professional Perceptions of Telemonitoring for Hypertension Management: Qualitative Study
Authors: Baratta Juliana , Brown-Johnson Cati , Safaeinili Nadia , Goldman Rosas Lisa , Palaniappan Latha , Winget Marcy , Mahoney Megan 
Published: April 2022

Background
Hypertension is the most prevalent and important risk factor for cardiovascular disease, affecting nearly 50% of the US adult population; however, only 30% of these patients achieve controlled blood pressure (BP). Incorporating strategies into primary care that take into consideration individual patient needs, such as remote BP monitoring, may improve hypertension management.

Objective
From March 2018 to December 2018, Stanford implemented a precision health pilot called Humanwide, which aimed to leverage high-technology and high-touch medicine to tailor individualized care for conditions such as hypertension. We examined multi-stakeholder perceptions of hypertension management in Humanwide to evaluate the program’s acceptability, appropriateness, feasibility, and sustainability.

Methods
We conducted semistructured interviews with 16 patients and 15 health professionals to assess their experiences with hypertension management in Humanwide. We transcribed and analyzed the interviews using a hybrid approach of inductive and deductive analysis to identify common themes around hypertension management and consensus methods to ensure reliability and validity.

Results
A total of 63% (10/16) of the patients and 40% (6/15) of the health professionals mentioned hypertension in the context of Humanwide. These participants reported that remote BP monitoring improved motivation, BP control, and overall clinic efficiency. The health professionals discussed feasibility challenges, including the time needed to analyze BP data and provide individualized feedback, integration of BP data, technological difficulties with the BP cuff, and decreased patient use of remote BP monitoring over time.

Conclusions
Remote BP monitoring for hypertension management in Humanwide was acceptable to patients and health professionals and appropriate for care. Important challenges need to be addressed to improve the feasibility and sustainability of this approach by leveraging team-based care, engaging patients to sustain remote BP monitoring, standardizing electronic medical record integration of BP measurements, and finding more user-friendly BP cuffs.
Thai Consumers’ Decision to Use Electric Vehicles and the Government Policies
Authors: Koojaroenprasit Sauwaluck , Pumpinyo Sumaree 
Published: April 2022

Abstract This paper aimed to analyze the importance of government policies and the decision to use Electric Vehicles (EV) for Thai consumer. The paper comparing those who use Electric Vehicles to those tend to use soon. Primary data was obtained from questionnaire. The sample size was 415 comprising 224 of those who use EV and 191 of those tend to use EV soon. Methodology employed the t statistics for hypotheses testing between these two groups. The government policies in this study included import tariff reduction, special privileged for EV users and subsidy and or rebate for EV buyers. Among these government policies, both EV users and intended EV users concerned the most importance in the reduction of import tariff and for the hypothesis test showed that these two-sample group emphasized not significantly different in these policies. The policy makers should implement the reduction on import tariff as soon as possible. Keywords: government policies, EV
Implications of Co-Working Experience Between Audit Partners
Authors: Huang Ting-Chiao , Chen Chen , Kaplan Steven E. , Lin Yi-Hung 
Published: April 2022

SUMMARY
This article summarizes a study by Huang, Chen, Kaplan, and Lin (2021) which examines whether increases in co-working experience between the lead and concurring audit partners affect engagement audit quality and audit efficiency. The study uses data from Taiwan, where the identities of lead and concurring audit partners are known, and where the role of the concurring partner is different than that of an engagement quality reviewer. This article describes the findings of Huang et al. (2021) and discusses the study's implications to audits in Taiwan and elsewhere which may be of interest to practitioners, regulators, and academics.
Client Acquisition Following an Auditor’s Unethical Behavior: An Examination of Reputational Consequences Following KPMG’s “Steal the Exam” Scandal
Authors: Hale Kevin , Truelson J. Mike 
Published: April 2022

SYNOPSIS
We investigate the reputational effects of KPMG’s scandal involving the improper receipt of confidential regulator data by analyzing KPMG’s acquisition of new audit clients in the post-scandal period. While we find no evidence that KPMG had difficulty gaining clients relative to a broad class of other large auditors, we do find that KPMG’s acquisition rate decreased in the post-scandal period in comparison to other Big 4 audit firms but increased relative to large non-Big 4 auditors. This finding indicates a shift in KPMG’s position in the market for new clients. Our results suggest that a more nuanced examination of auditor reputational damages may help detect distinct effects between classes of audit firms. Importantly, our findings may be of interest to practitioners and researchers as they consider the consequences of a high-profile scandal on an audit firm’s reputation, even if the scandal does not appear to directly impact engagement-level audit quality.
Data Availability: Data used in this study are available from public sources identified in the document.
JEL Classifications: M42; M48.
Exendin-(9-39) Effects on Glucose and Insulin in Children With Congenital Hyperinsulinism During Fasting and During a Meal and a Protein Challenge
Authors: Stefanovski Darko , Vajravelu Mary E. , Givler Stephanie , De León Diva D. 
Published: April 2022

OBJECTIVE
The aim of this study was to assess whether exendin-(9-39) will increase fasting and postprandial plasma glucose and decrease the incidence of hypoglycemia in children with hyperinsulinism (HI).

RESEARCH DESIGN AND METHODS
This was an open-label, four-period crossover study. In periods 1 and 2, the effect of three different dosing regimens of exendin-(9-39) (group 1, 0.28 mg/kg; group 2, 0.44 mg/kg; group 3, 0.6 mg/kg) versus vehicle on fasting glucose was assessed in 16 children with HI. In periods 3 and 4, a subset of eight subjects received either vehicle or exendin-(9-39) (0.6 mg/kg) during a mixed-meal tolerance test (MMTT) and an oral protein tolerance test (OPTT).

RESULTS
Treatment group 2 showed 20% (P = 0.037) increase in the area under the curve (AUC) of fasting glucose. A significant increase in AUC of glucose was also observed during the MMTT and OPTT; treatment with exendin-(9-39) resulted in 28% (P ≤ 0.001) and 30% (P = 0.01) increase in AUC of glucose, respectively. Fasting AUC of insulin decreased by 57% (P = 0.009) in group 3. In contrast, AUC of insulin was unchanged during the MMTT and almost twofold higher (P = 0.004) during the OPTT with exendin-(9-39) treatment. In comparison with vehicle, infusion of exendin-(9-39) resulted in significant reduction in likelihood of hypoglycemia in group 2, by 76% (P = 0.009), and in group 3, by 84% (P = 0.014). Administration of exendin-(9-39) during the OPTT resulted in 82% (P = 0.007) reduction in the likelihood of hypoglycemia.

CONCLUSIONS
These results support a therapeutic potential of exendin-(9-39) to prevent fasting and protein-induced hypoglycemia in children with HI.