bluuebunny/crossref_metadata_2025_split huggingface dataset:
The nature and frequency of relative clauses in the language children hear and the language children read: A developmental cross-corpus analysis of English complex grammar
Authors: HSIAO Yaling , DAWSON Nicola J. , BANERJI Nilanjana , NATION Kate 
Published: March 2022

AbstractAs written language contains more complex syntax than spoken language, exposure to written language provides opportunities for children to experience language input different from everyday speech. We investigated the distribution and nature of relative clauses in three large developmental corpora: one of child-directed speech (targeted at pre-schoolers) and two of text written for children – namely, picture books targeted at pre-schoolers for shared reading and children’s own reading books. Relative clauses were more common in both types of book language. Within text, relative clause usage increased with intended age, and was more frequent in nonfiction than fiction. The types of relative clause structures in text co-occurred with specific lexical properties, such as noun animacy and pronoun use. Book language provides unique access to grammar not easily encountered in speech. This has implications for the distributional lexical-syntactic features and associated discourse functions that children experience and, from this, consequences for language development.
Developmental inflection point for the effect of maternal childhood adversity on children’s mental health from childhood to adolescence: Time-varying effect of gender differences
Authors: Lee Jungeun Olivia , Duan Lei , Lee Woo Jung , Rose Jennifer , Oxford Monica L. , Cederbaum Julie A. 
Published: March 2022

AbstractChildhood adversities have a well-established dose–response relationship with later mental health. However, less attention has been given to intergenerational influences. Further, it is unknown how intergenerational influences intersect with children’s developmental stages and gender. The current study examined whether a developmental inflection point exists when the intergenerational influences of childhood adversities gain salience and explored differences by children’s gender. Data were from the Young Women and Child Development Study (n = 361). Time-varying effect models (TVEMs) and moderation TVEMs by child’s gender were evaluated. Our findings reveal that ages 5–8, the period of transition into primary schools, may represent a developmental inflection point when the intergenerational influences of maternal childhood adversity start emerging substantially. The results from gender interaction TVEMs reveal that maternal childhood adversity was a statistically significant predictor of internalizing problems until age 11, regardless of child’s gender, and remained statistically significant for girls’ internalizing problems until age 16.7. For externalizing problems, maternal childhood adversity was a statistically significant predictor until age 13, regardless of gender.
Left ventricular-infundibular apical septal defect: a rare entity revisited
Authors: Kakarla Saikiran , Sasikumar Deepa , Kurup Harikrishnan K. N. 
Published: March 2022

AbstractApical ventricular septal defects are a heterogeneous group of septal defects that need accurate anatomic characterisation for planning appropriate management. Left ventricular-infundibular apical septal defects are defects between the left ventricular septum and the infundibular apex of the right ventricle with distinctive morphological features. We describe two illustrative examples of this septal defect with focus on their therapeutic implications and long-term outcome.
How the ARCH Project has Contributed to the Development of the ASEAN Regional Collaboration Mechanism on Disaster Health Management
Authors: Silapunt Phumin , Fernando Ferdinal , Catampongan Jim , Limpaporn Sansana , Yuddhasaraprasiddhi Kittima , Promkhum Dangfun , Tianwibool Parinya , Sairai Phatsawan , Rungsansarit Hathairat , Wuthisuthimethawee Prasit , Keeratipongpaiboon Kanin , Tantivesruangdet Nopmanee , Chantaratin Kanungnij , Tiyawat Gawin , Takada Yosuke , Kita Taro , Kai Soichiro , Ikeda Shuichi 
Published: March 2022

AbstractObjective:This paper aims to clarify how the Project for Strengthening the ASEAN Regional Capacity on Disaster Health Management (ARCH Project) strengthened regional collaboration mechanisms on disaster health management (DHM) in ASEAN.Methods:The political process and the relevant documents of the ARCH Project were reviewed.Results:The ARCH Project established the Regional Coordination Committee as a coordination platform for providing strategic direction to the project and strengthening the regional coordination of DHM. Also, the Project Working Groups and Sub-Working Groups were set up as implementation bodies for the project activities with representatives of ASEAN Member States (AMS). With support from DHM experts of Japan and Thailand, a series of discussions were conducted for the development of a Standard Operating Procedure (SOP) for the Coordination of International Emergency Medical Teams (I-EMTs), regional tools, and collective measures supporting AMS to overcome challenges, and thereby meeting the minimum requirements set by the WHO EMT Initiative. The progress and outputs of the ARCH Project are subsequently elevated to the ASEAN Health Sector for endorsement, the updates are further shared to the Joint Task Force to Promote Synergy with Other Relevant ASEAN Bodies on Humanitarian Assistance and Disaster Relief (JTF-HADR) for the implementation of the ASEAN Declaration on One ASEAN One Response. The initiation of the ARCH Project in July 2016 has resulted in the development of the ASEAN regional collaboration framework, including the establishment of the Regional Coordination Committee on Disaster Health Management (RCCDHM), the SOP for ASEAN I-EMT coordination, and regional tools, such as forms for Medical Record for Emergency and Disaster and Health Needs Assessment. Moreover, further discussions on ASEAN Collective Measures that aim to support AMS to meet the WHO EMT minimum standards and strengthening I-EMT coordination capacity were also conducted. As adopted by the ASEAN Health Ministers Meeting (AHMM) in 2019, the RCCDHM was established as one of the mechanisms to operationalize the Plan of Action to implement the ASEAN Leaders’ Declaration on DHM.Conclusion:The contribution of the ARCH Project to strengthen the ASEAN regional capacity in DHM has enhanced the regional coordination platform, with a formalization of RCCDHM as ASEAN’s official regional mechanism, and of the on-going integration process of the SOP for EMT coordination into the ASEAN SASOP.
Design of monopole antennas based on progressive Gaussian process
Authors: Zheng Xie , Meng Fei , Tian Yubo , Zhang Xinyu 
Published: March 2022

AbstractElectromagnetic simulation software has become an important tool for antenna design. However, high-fidelity simulation of wideband or ultra-wideband antennas is very expensive. Therefore, antenna optimization design by using an electromagnetic solver may be limited due to its high computational cost. This problem can be alleviated by the utilization of fast and accurate surrogate models. Unfortunately, conventional surrogate models for antenna design are usually prohibitive because training data acquisition is time-consuming. In order to solve the problem, a modeling method named progressive Gaussian process (PGP) is proposed in this study. Specially, when a Gaussian process (GP) is trained, test sample with the largest predictive variance is inputted into an electromagnetic solver to simulate its results. After that, the test sample is added to the training set to train the GP progressively. The process can incrementally increase some important trusted training data and improve the model generalization performance. Based on the proposed PGP, two monopole antennas are optimized. The optimization results show effectiveness and efficiency of the method.
A Single Dras‐Kohistan‐Ladakh Arc Revealed by Volcaniclastic Records
Authors: Andjić Goran , Zhou Renjie , Jonell Tara N. , Aitchison Jonathan C. 
Published: March 2022

AbstractTectonic interpretations of arc remnants in the Himalayan orogen remain uncertain, despite their important implications for the overall convergence history between India and Eurasia. Provenance results from deep‐water volcaniclastic rocks of the Indus Suture Zone in Ladakh provide new constraints on the Mesozoic tectonic evolution of the Dras and Kohistan‐Ladakh arcs. Detrital zircon (DZ) U‐Pb ages and whole‐rock geochemistry of the fault‐bounded Upper Cretaceous Nindam and Paleocene Jurutze formations present age patterns and compositions that are consistent with those of the Dras and Kohistan‐Ladakh arcs, respectively. The combination of DZs of the Nindam and Jurutze formations with the igneous zircons of the Dras and Kohistan‐Ladakh arcs shows similar age distributions that support a Late Jurassic to Paleocene tectonic connection between all these units. We argue that the secular trends in geochemical composition of DZs and volcaniclastic material are consistent with the magmatic evolution of one convergent margin, which shifted from a primitive to a mature stage during the Late Cretaceous. The recognition of a single Dras‐Kohistan‐Ladakh arc sets the stage for reevaluating competing scenarios of the Mesozoic evolution of the India–Eurasia convergent system. We find that the most likely scenario is that of a Jurassic arc formed above a south‐dipping intraoceanic subduction zone and accreted to Eurasia during the Early Cretaceous, after which it evolved above a north‐dipping subduction zone.
Increasing Functional Diversity in a Global Land Surface Model Illustrates Uncertainties Related to Parameter Simplification
Authors: Butler Ethan E. , Wythers Kirk R. , Flores‐Moreno Habacuc , Ricciuto Daniel M. , Datta Abhirup , Banerjee Arindam , Atkin Owen K. , Kattge Jens , Thornton Peter E. , Anand Madhur , Burrascano Sabina , Byun Chaeho , Cornelissen J. H. C. , Forey Estelle , Jansen Steven , Kramer Koen , Minden Vanessa , Reich Peter B. 
Published: March 2022

AbstractSimulations of the land surface carbon cycle typically compress functional diversity into a small set of plant functional types (PFT), with parameters defined by the average value of measurements of functional traits. In most earth system models, all wild plant life is represented by between five and 14 PFTs and a typical grid cell (≈100 × 100 km) may contain a single PFT. Model logic applied to this coarse representation of ecological functional diversity provides a reasonable proxy for the carbon cycle, but does not capture the non‐linear influence of functional traits on productivity. Here we show through simulations using the Energy Exascale Land Surface Model in 15 diverse terrestrial landscapes, that better accounting for functional diversity markedly alters predicted total carbon uptake. The shift in carbon uptake is as great as 30% and 10% in boreal and tropical regions, respectively, when compared to a single PFT parameterized with the trait means. The traits that best predict gross primary production vary based on vegetation phenology, which broadly determines where traits fall within the global distribution. Carbon uptake is more closely associated with specific leaf area for evergreen PFTs and the leaf carbon to nitrogen ratio in deciduous PFTs.
Size‐Dependent Characteristics of Surface‐Rooted Three‐Dimensional Convective Objects in Continental Shallow Cumulus Simulations
Authors: Griewank Philipp J. , Heus Thijs , Neggers Roel A. J. 
Published: March 2022

AbstractA segmentation algorithm is applied to high resolution simulations of shallow continental convection to identify individual convective 3D objects within the convective boundary layer, in order to investigate which properties of the objects vary with the object width. The study analyses the geometry of the objects, along with their profiles of vertical velocity and total water, to assess various assumptions often used in spectral mass‐flux convection schemes. The methodology of this paper is unique in that we use (a) a novel application of the watershed algorithm to detect individual objects in the constantly evolving continental boundary layer efficiently, and (b) an unprecedentedly large number of simulations being analyzed. In total, 26 days of LASSO simulations at the Atmospheric Radiation Measurement Southern Great Plains site are analyzed, yielding roughly one million objects. Plume‐like surface‐rooted objects are found to be omnipresent, the vertical extent of which is strongly dependent on the object width. The vertical velocity and moisture anomaly profiles of the widest objects are roughly consistent with the classic buoyancy‐driven rising plume model. The kinematic and thermodynamic properties of the objects vary with object width. This width dependence is strongest above cloud base, but much weaker below. Finally the impact of neglecting the contribution of covariances to the vertical moisture flux, which is commonly used in mass‐flux parameterizations, is investigated. The average effect of neglecting covariances increases linearly with object width, leading to a 20% flux underestimation for 2 km wide objects. Implications of the results for spectral convection scheme development are briefly discussed.
Modeling and Validating a SuperDARN Radar's Poynting Flux Profile
Authors: Perry G. W. , Ruzic K. D. , Sterne K. , Howarth A. D. , Yau A. W. 
Published: March 2022

AbstractWe have developed a model that simulates the Poynting flux profile of the Saskatoon Super Dual Auroral Radar Network (SuperDARN) radar at ionospheric altitudes. The model uses ray tracing software to project the radar system's vacuum Poynting flux profile through the ionosphere, taking into account the influence of the ionospheric medium on the propagation characteristics of the high frequency radio waves. Measurements of the radar's transmissions by the Radio Receiver Instrument (RRI) in low‐Earth orbit are used to validate the model during five experiments which occurred between 4 and 8 August 2017. Comparisons between simulated and measured RRI antenna voltages show good agreement, although there are clear instances in which the model underperforms. Nevertheless, the model demonstrates its utility as a tool for interpreting RRI measurements of SuperDARN radars. The model also helps address a lack of knowledge of a SuperDARN radar's Poynting flux profile at ionospheric altitudes. In particular, we assess the assumption that SuperDARN's scattering volume lies along the great‐circle path of the transmitting beam's bearing. Comparisons between the model and RRI's measurements show that this assumption is reasonable for the five experiments investigated in this work. The model presents a new way of carrying out SuperDARN and high frequency radio science investigations.
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability
Authors: Caldeira G. L. , Inácio A. S. , Beltrão N. , Barreto C. A. V. , Rodrigues M. V. , Rondão T. , Macedo R. , Gouveia R. P. , Edfawy M. , Guedes J. , Cruz B. , Louros S. R. , Moreira I. S. , Peça J. , Carvalho A. L. 
Published: March 2022

AbstractMutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse. Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary proteins that regulate crucial aspects of receptor function. Here, we investigate a mutant form of the TARP family member stargazin, described in an ID patient. Molecular dynamics analyses predicted that the ID-associated stargazin variant, V143L, weakens the overall interface of the AMPAR:stargazin complex and impairs the stability of the complex. Knock-in mice harboring the V143L stargazin mutation manifest cognitive and social deficits and hippocampal synaptic transmission defects, resembling phenotypes displayed by ID patients. In the hippocampus of stargazin V143L mice, CA1 neurons show impaired spine maturation, abnormal synaptic transmission and long-term potentiation specifically in basal dendrites, and synaptic ultrastructural alterations. These data suggest a causal role for mutated stargazin in the pathogenesis of ID and unveil a new role for stargazin in the development and function of hippocampal synapses.
Loss of IRF7 accelerates acute myeloid leukemia progression and induces VCAM1-VLA-4 mediated intracerebral invasion
Authors: Wang Hao , Zhang Dongyue , Cui Xiaoxi , Dai Yibo , Wang Chenchen , Feng Wenli , Lv Xiaoqian , Li Yifei , Wang Lina , Ru Yongxin , Zhang Yingchi , Ren Qian , Zheng Guoguang 
Published: March 2022

AbstractInterferon regulatory factor 7 (IRF7) is widely studied in inflammatory models. Its effects on malignant progression have been documented mainly from the perspective of the microenvironment. However, its role in leukemia has not been established. Here we used MLL-AF9-induced acute myeloid leukemia (AML) mouse models with IRF7 knockout or overexpression and xenograft mouse models to explore the intrinsic effects of IRF7 in AML. AML-IRF7−/− mice exhibited accelerated disease progression with intracerebral invasion of AML cells. AML-IRF7−/− cells showed increased proliferation and elevated leukemia stem cell (LSC) levels. Overexpression of IRF7 in AML cells decreased cell proliferation and LSC levels. Furthermore, overexpression of transforming growth-interacting factor 1 (TGIF1) rescued the enhanced proliferation and high LSC levels caused by IRF7 deficiency. Moreover, upregulation of vascular cell adhesion molecule 1 (VCAM1), which correlated with high LSC levels, was detected in AML-IRF7−/− cells. In addition, blocking VCAM1-very late antigen 4 (VLA-4) axis delayed disease progression and attenuated intracerebral invasion of AML cells. Therefore, our findings uncover the intrinsic effects of IRF7 in AML and provide a potential strategy to control central nervous system myeloid leukemia.
PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway
Authors: Liu Tao , Zhang Junling , Chen Hu , Bianba Tashi , Pan Yisheng , Wang Xin , Jiang Yong , Yang Zhen 
Published: March 2022

AbstractAs one of the most common malignant tumors, it is particularly important to further understand the development mechanism of gastric cancer and to find more effective therapeutic target genes. The results of immunohistochemical staining showed that PSMC2 was upregulated in gastric cancer. Cell function experiments indicated that PSMC2 knockdown inhibited the proliferation, clone formation and migration of gastric cancer cells, and induced apoptosis. In vivo experiments further showed that PSMC2 knockdown suppressed tumor growth. RPS15A and mTOR pathway were identified the downstream gene and pathway of PSMC2 by GeneChip and IPA. PSMC2 knockdown inhibited RPS15A expression and mTOR pathway, which was neutralized by RPS15A overexpression. Overexpression of RPS15A promoted the proliferation and migration of gastric cancer cells, which alleviated the inhibitory effect caused by PSMC2 knockdown to a certain extent. The mTOR pathway inhibitor Torin1 partially restored the promoting role of RPS15A overexpression on the gastric cancer cell proliferation. Furthermore, bioinformatics analysis and dual-luciferase reporter assays showed that PSMC2 and RPS15A competitively bound to hsa-let-7c-3p. Inhibition of hsa-let-7c-3p promoted the migration of MGC-803 cells and reduced the apoptosis level, while simultaneous inhibition PSMC2 and hsa-let-7c-3p restored the migration and apoptosis levels of gastric cancer cells. In conclusion, PSMC2 and RPS15A were highly expressed in gastric cancer. PSMC2 enhanced RPS15A levels by targeting hsa-let-7c-3p, and then activated mTOR pathway, thereby promoting the progression of gastric cancer.
Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial
Authors: Zhang Xiaoying , Miao Miao , Zhang Ruijun , Liu Xu , Zhao Xiaozhen , Shao Miao , Liu Tian , Jin Yuebo , Chen Jiali , Liu Huixin , Zhang Xia , Li Yun , Zhou Yunshan , Yang Yue , Li Ru , Yao Haihong , Liu Yanying , Li Chun , Li Yuhui , Ren Limin , Su Yin , Sun Xiaolin , He Jing , Li Zhanguo 
Published: March 2022

AbstractRheumatoid arthritis (RA) is an aggressive autoimmune arthritis, and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects. Low-dose interleukin-2 (Ld-IL2) is potentially a therapeutic approach to further improve the disease. This randomized, double-blind, placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA. Patients were randomly assigned (1:1) to receive Ld-IL2, defined as a dose of 1 million IU, or placebo in a 12-week trial with a 12-week follow-up. Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks (a total of 7 doses), followed by a 2-week break. All patients received a stable dose of methotrexate (MTX). The primary outcomes were the proportion of patients achieving the ACR20, DAS28-ESR <2.6, and the change from baseline in CDAI or SDAI at week 24. Secondary endpoints included other clinical responses and safety. The primary outcomes were achieved in the per-protocol population. The improvements from baseline in CDAI and SDAI were significantly greater across time points for the Ld-IL2 + MTX group (n = 17) than for the placebo+MTX group (n = 23) (P = 0.018 and P = 0.015, respectively). More patients achieved ACR20 response in the Ld-IL2 + MTX group than those in the placebo+MTX group at week 12 (70.6% vs 43.5%) and at week 24 (76.5% vs 56.5%) (P = 0.014). In addition, low Treg and high IL-21 were associated with good responses to Ld-IL2. Ld-IL-2 treatment was well-tolerated in this study. These results suggested that Ld-IL2 was effective and safe in RA. ClinicalTrials.gov number: NCT 02467504.
Cancer and its predictors in Chinese adults with newly diagnosed diabetes and impaired glucose tolerance (IGT): a 30-year follow-up of the Da Qing IGT and Diabetes Study
Authors: He Siyao , Wang Jinping , Shen Xiaoxia , Qian Xin , An Yali , Gong Qiuhong , Zhang Bo , Chen Bo , Zhang Lihong , Chen Xiaoping , Chen Yanyan , Li Guangwei 
Published: March 2022

Abstract
Background
We aimed to explore if hyperglycaemia and hyperinsulinemia in the diabetes and prediabetes population were associated with increased risk of cancer occurence.

Methods
Overall, 1700 participants with different glycaemic statuses were screened from the 110,660 residents of Da-Qing, China, in 1985. They were followed up to 30 years to access cancer outcomes.

Results
Cancer was identified in 15.2% (259/1700) of the participants. The incidence of cancer in the normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes groups was 6.06, 6.77, and 7.18 per 1000 person-years, respectively (P = 0.02). In the Fine-Gray model with all cause death as competing risk, compared with the NGT controls, both IGT and diabetes groups demonstrated significantly higher risk of cancer (for the IGT group, adjusted hazard ratio (aHR) = 1.77, 95% CI 1.38–2.27, P < 0.0001; for the diabetes, aHR = 3.34, 95% CI 2.64–4.22, P < 0.0001). Among the IGT participants, progress to diabetes (aHR = 2.28, 95%CI 1.24–4.20, P = 0.008) and insulin-area under the curve at baseline (for 1 SD increase, aHR = 1.39, P = 0.02) were also associated with the risk of cancer after adjustment of covariables.

Conclusions
Hyperglycaemia in patients with diabetes, hyperinsulinemia, and progression to diabetes in people with IGT is significantly associated with the long-term increased risk of cancer occurrence.