bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering N7-Methylguanosine regulator-mediated methylation modification pattern and Landscape of anti-PD-1/L1 Immunotherapy and immune microenvironment infiltration characterization in Lower-Grade Glioma
Authors: Maimaiti Aierpati , Feng Zhaohai , Liu Yanwen , Turhon Mirzat , Xie Zhihao , Baihetiyaer Yilimire , Wang Xixian , Kasimu Maimaitijiang , Jiang Lei , Wang Yongxin , Wang Zengliang , Pei Yinan 
Published: December 2022

Abstract
Background: N7-methylguanosine (m7G) modification signature has been found recently in cancer and is now known as an essential regulator of tumor progression and treatment. As a result of the function of m7G methylation modification genes in tumorigenesis and progression, there isn't much information related to the genomic profile of lower-grade gliomas(LGGs).
Methods: In this research, bioinformatics analysis methods were used to characterize m7G modifications in individuals with LGG from The Chinese Glioma Genome Atlas(CGGA) and The Cancer Genome Atlas(TCGA). Afterward, gene set enrichment analysis(GSEA), single sample GSEA(ssGSEA), CIBERSORT algorithm, ESTIMATE algorithm, R package "GSVA," and TIDE were used to evaluate the association between m7G modification patterns, TME cell infiltration properties as well as the correlation regarding immune infiltration markers. The m7G scoring scheme using principal component analysis(PCA) was employed to investigate the m7G modification patterns of individual tumors quantitatively. We examined the m7G modification hub genes' expression levels in normal samples, refractory epilepsy samples, and lower-grade glioma samples using immunohistochemistry, western-blotting, and QRT-PCR.
Result: It was discovered that individuals with LGG were categorized into two groups in terms of m7G scores (high and low) as per the properties of m7G. After observing the anti-PD-1 cohort, it has been noted that individuals having a high m7G score had significant clinical benefit, along with considerably prolonged survival duration. Opposing this, individuals in the anti-PD-L1 cohort having low m7G scores had improved prognostic outcomes and were more likely to have CR(Complete Response) / PR(Partial Response). Different m7G subtypes have different TMB(Tumor Mutational Burden) and immune profiles and might have varied responses to immunotherapy. Moreover, five potential genetic markers were found that were highly correlated with the index of the m7G score signature.
Conclusion: Conclusively, a thorough investigation of the features and classification associated with m7G methylation modifications may improve the clinical outcome of LGG.
A scoping review of implementation considerations for Harm Reduction Vending Machines
Authors: Russell Erin , Johnson Jessica , Kosinski Zachary , Kaplan Callie , Barnes Nicole , Allen Sean , Haroz Emily 
Published: December 2022

Abstract

Background
Community-based harm reduction vending machines (HRVM) are not new to the field of public health; numerous countries have implemented them in response to the needs of people who use drugs over the last three decades. However, until recently, few existed in the United States. Given the rapidity with which communities are standing up harm reduction vending machines, there is a pressing need for a consolidated examination of implementation evidence. This scoping review summarizes existing literature using multiple implementation science frameworks.
Methods
The scoping review was conducted in five stages including 1) Identify the research question; 2) Identify relevant studies; 3) Select the publications based on inclusion/exclusion criteria; 4) Review and extract data; and, 5) Summarize results. PubMed, Embase, and Web of Science were searched and authors screened publications in English from any year. Data were extracted by applying implementation constructs from RE-AIM and the Consolidated Framework for Implementation Research (CFIR). Both frameworks provided a useful lens through which to develop knowledge about the facilitators and barriers to HRVM implementation. The review is reported according to PRISMA guidelines.
Results
After applying the full inclusion and exclusion criteria, including the intervention of interest (“vending machines”) and population of interest (“people who use drugs”), a total of 23 studies were included in the scoping review. None of the studies reported on race, making it difficult to retroactively apply a racial equity lens. Among those articles that examined effectiveness, the outcomes were mixed between clear effectiveness and inconclusive results. Evidence emerged, however, to address all CFIR constructs, and positive outcomes were observed from HRVM’s after-hour availability and increased program reach.
Recommendations:
HRVM implementation best practices include maximizing accessibility up to 24 hours, 7 days a week, offering syringe disposal options, ensuring capability of data collection, and allowing for anonymity of use. Organizations that implement HRVM should establish strong feedback loops between them, their program participants, and the broader community upfront. Considerations for future research include rigorous study designs to evaluate effectiveness outcomes (e.g. reduced drug overdose deaths) and examination of HRVM reach among ethnic and racial communities.
Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
Authors: Nettersheim Felix Sebastian , Schlüter Johannes David , Kreuzberg Wiebke , Geißen Simon , Mehrkens Dennis , Grimm Simon , Nemade Harshal , Braumann Simon , Hof Alexander , Guthoff Henning , Peters Vera , Kargapolova Yulia , Lackmann Jan-Wilm , Müller Stefan , Pallasch Christian P. , Hallek Michael , Sachinidis Agapios , Adam Matti , Winkels Holger , Baldus Stephan , Mollenhauer Martin 
Published: December 2022

Abstract
Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention of anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels of the neutrophil-derived enzyme myeloperoxidase (MPO) predict occurrence of AICM in humans. We hypothesized that MPO release causally contributes to AICM. Mice intravenously injected with the anthracycline Doxorubicin (DOX) exhibited higher neutrophil counts and MPO levels in the circulation and cardiac tissue compared to saline (NaCl)-treated controls. Neutrophil-like HL-60 cells exhibited increased MPO release upon exposition to DOX. DOX induced extensive nitrosative stress in cardiac tissue alongside with increased carbonylation of sarcomeric proteins in wildtype but not in Mpo-/- mice. Accordingly, co-treatment of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with DOX and MPO aggravated loss of hiPSC-CM-contractility compared to DOX treatment alone. DOX-treated animals exhibited pronounced cardiac apoptosis and inflammation, which was attenuated in MPO-deficient animals. Finally, genetic MPO deficiency and pharmacological MPO inhibition protected mice from the development of AICM. Herein we identify MPO as a critical mediator of AICM. We demonstrate that DOX induces cardiac neutrophil infiltration and release of MPO, which directly impairs cardiac contractility through promoting oxidation of sarcomeric proteins, cardiac inflammation and cardiomyocyte apoptosis. MPO thus emerges as a promising pharmacological target for prevention of AICM.
The Dynamic Impact of Renewable Energy Consumption, Trade, and Financial Performance on Carbon Emissions Worldwide in Low, Middle and High Income Countries: A Quantile Regression Approach
Authors: Nasrullah Nasrullah , Husnain Muhammad Iftikhar ul , Khan Muhammad Aamir 
Published: December 2022

Abstract
The present study confronts potential theoretical argument of dynamic and non-linear relationship between CO2 emissions, renewable energy consumption, trade, and financial performance by using quantile regression that accounts for the role of development in explaining the stated nexus. The results show that renewable energy consumption reduces CO2 emissions in the short run in low, middle, and high-income countries. CO2 emissions plumet as country open up for trade and expand financial services for their people. It is found that trade openness and financial development decrease CO2 emissions at upper quantile in low-income countries. In the middle-income countries the findings are not much different as reported in case of low-income countries. In the high-income countries, renewable energy consumption and trade openness lead to decrease in CO2 emissions at all income quantiles. The D-H causality test draws a sturdy support of bi-directional causation between renewable energy and CO2 emissions in low- income countries. Based on this analysis, some important policy implications can be drawn. First, in advanced countries restrictions on renewable energy does not have significant effect on environmental condition. However, in low-income countries adoption of renewable energy can significantly reduce CO2 emissions. Second, low-income countries may combat rise in CO2 emissions by introducing new technologies in exploiting trade potentials that are necessary to acquire resources to adopt clean energy. Third, energy policies should be framed based on the stage of development of a country, share of renewable energy in its total energy mix, and environmental condition of the country.
A quantitative analysis of human rights-related attitude changes towards people with mental health conditions and psychosocial, intellectual, or cognitive disabilities following completion of the WHO QualityRights e-training in Ghana
Authors: Poynton-Smith Emma , Orrell Martin , Osei Akwasi , Ohene Sally-Ann , Ansong Joana , Gyimah Leveana , McKenzie Caitlin , Moro Maria Francesca , Drew-Bold Nathalie , Baingana Florence , Carta Mauro Giovanni , Tawiah Priscilla , Brobbey Kwaku , Funk Michelle 
Published: December 2022

Abstract
Background
Despite growing recognition of essential human rights, people with mental health conditions and psychosocial, intellectual, or cognitive disabilities’ rights are known to be frequently violated in mental healthcare worldwide, with common use of coercive practices and limited recognition of people’s right to exercise their legal capacity and make decisions for themselves on treatment and other issues affecting them.
To tackle this issue, Ghana adopted the WHO QualityRights Initiative in 2019. This aims to introduce a right-based, person-centred recovery approach within the mental health care system, protecting and promoting the rights of people with mental health conditions, psychosocial, cognitive, and intellectual disabilities in the healthcare context and community.
Methods
E-training (capacity-building) was provided in Ghana across a broad array of stakeholder groups including healthcare professionals, carers, and people with lived experience. The training covered legal capacity, coercion, community inclusion, recovery approach, service environment, and the negative attitudes commonly held by stakeholder groups; it was completed by 17,000 people in Ghana as of December 2021.
We assessed the impact of the e-training on attitudes through comparing trainees’ pre- and post-questionnaire responses on 17 items, each measured on a 5-point Likert scale (strongly disagree to strongly agree), such that higher scores indicated negative attitudes towards persons with mental health conditions and psychosocial disabilities as rights holders.
Analyses were conducted on two main groups: matched pairs (417 pairs of baseline and follow-up questionnaire responses matched to a high degree of certainty), and the unmatched group (4299 individual completed questionnaire responses).
Results
We assessed the impact of the WHO QualityRights e-training on attitudes: training resulted in highly significant attitude changes towards alignment with human rights, with scores changing by approximately 40% between baseline and follow-up. In particular, attitude changes were seen in items representing treatment choice, legal capacity, and coercion. This change was not affected by age, gender, or background experience.
Conclusions
The QualityRights e-training programme is effective in changing people’s (especially healthcare professionals’) attitudes towards people with mental health conditions and psychosocial, intellectual, or cognitive disabilities: this is a step towards mental healthcare being more with human rights-based worldwide.
Impact of mineral fertilizers on anaerobic digestion of vegetable waste
Authors: Borowski Sebastian , Cieciura-Włoch Weronika , Boniecki Paweł , Bednarek Agata 
Published: December 2022

Abstract
This study investigated the use of mineral fertilizers for the improvement of biogas production from vegetable wastes. Five fertilizers of various chemical composition were selected, and two blends of vegetable wastes were composed for the experiments. The results demonstrated the highest improvement in biogas production using the mineral fertilizer SUBSTRAL dedicated to conifers, which was characterized by a diverse chemical composition and the lack of sulfur. The addition of this fertilizer in a dose of 1 g/kg increased methane and hydrogen yields by up to 49% compared to the control. The maximum methane production of 336 NmL/gVS was achieved after supplementation of the mixture containing corn, green pees and green bean wastes, whereas the highest hydrogen yield of 49 NmL/gVS was reported in the experiments with the blend containing carrot, cauliflower and broccoli. A simplified cost analysis showed that the use of 1 kg of mineral fertilizer to supplement the anaerobic digestion of vegetable waste for biogas production can generate additional revenues of up to 2399 €.
Video-based Task Deconstruction of Robotic Hiatal Hernia Repair
Authors: Calvo Haydee del , Kim Min P , Chihara Ray , Chan Edward Y 
Published: December 2022

Abstract
Introduction: Robotic surgery is increasingly permeating the surgical arena and expanding the role of minimally invasive surgical approaches. Due to this, teaching robotic skills to general surgery residents is critically important. Standardized tools for teaching are lacking. Video based learning has demonstrated significant advancements. Video-based education addresses challenges within surgical training including increased knowledge retention within a continuously expanding field of information and a time-constrictive environment. We propose a surgical steps task deconstruction of robotic hiatal hernia repair with LINX paired with a surgical video following the same steps and using valuable video characteristics, as a standardized teaching tool.
Methods: Subject matter experts (SMEs) created a list of procedural steps for a robotic hiatal hernia repair with LINX. Four SMEs developed a comprehensive ten-step task list for the conduct of the operation, beginning with a literature review and employing a modified Delphi process to reach a consensus. A surgical video was created using narration and anatomic labeling to guide the learner through the Delphi process agreed upon ten procedural steps. The goal was to create a standardized set of tasks paired with video representation to facilitate teaching robotic HHR with LINX to novice learners.
Results: From an initial literature review, focus group discussions resulted in Delphi consensus on ten procedural steps, modified from the initial four steps. Creation of a video-based instruction tool with consideration for important characteristics such as narration and anatomic labeling allows for standardization of the performance and teaching of the operation, facilitating formative and summative feedback and assessment for learners by the supervising surgeon.
Conclusion: Development of a standardized task list paired with video-based learning for a robotic hiatal hernia repair with LINX provides the structure for teaching complex robotic surgery safely and efficiently to general surgery residents. Video-based education offers significant advantages in trainee learning, performance, and experience therefore it should be an integral part of surgical education.
The most frequently cited articles on chronic kidney disease and cerebrovascular disease from 2011 to 2021: A bibliometric and visualized analysis
Authors: Xue Taiqi , Zhang Leyi , Yan Pu , Gao Yiwei , Liu Wu , Guo Yifan , Zhang Ning 
Published: December 2022

Abstract
Background
There is growing evidence that suggests a strong relationship between chronic kidney disease and cerebrovascular disease. However, previous studies have only explored one aspect or feature of chronic kidney disease and cerebrovascular disease, with limited discussion of the current status and trends of research on both. This article provides a visual analysis of highly cited articles on chronic kidney disease and cerebrovascular disease, and further explores the current hotspots of interest and future trends. Understanding this relationship can help nephrologists and neurologists meet clinical and scientific needs.
Methods
On September 31, 2022, we screened and identified the 100 most frequently cited original articles on chronic kidney disease and cerebrovascular disease research topics. We then analyzed the articles by title, author, country, journal, article type (review, article, etc.), total citations, and keywords.
Results
The 100 articles we identified were cited a total of 3487 times (an average of 23.8 citations per paper). The journal that publishes the most articles from amongst these was the Journal of Stroke & Cerebrovascular Diseases (n = 12), followed by Cerebrovascular Diseases (n = 8), and American Journal of Kidney Diseases (n = 5). Japan produced 22 of the 100 articles, followed by The United States (n = 21) and China (n = 16). Clinical studies were most common (n = 66), followed by reviews (n = 32) and animal studies (n = 2). The main keywords were “chronic kidney disease,” “glomerular filtration rate,” “stroke,” “risk factor,” “cardiovascular-disease,” “small vessel disease,” “cognitive impairment,” “dialysis,” “renal dysfunction,” and “hemodialysis.”
Conclusions
This study identified the most influential articles in studies of chronic kidney disease and cerebrovascular disease over the last decade. The most prominent themes in the literature were explorations of the underlying mechanisms, particularly in terms of small vessel associations, searching for biomarkers that can predict their severity, and the prognosis and treatment of cerebrovascular disease in end-stage renal disease, particularly among dialysis patients.
Being pregnant and becoming a parent during the COVID-19 pandemic: a longitudinal qualitative study with women in the Born in Bradford COVID-19 research study
Authors: Jackson Cath , Brawner June , Ball Matthew , Crossley Kirsty , Dickerson Josie , Dharni Nimarta , Rodriguez Diego Garcia , Turner Ella , Sheard Laura , Smith Helen 
Published: December 2022

Abstract
Background
Uncertainty around the risk of COVID-19 to pregnant women and their babies prompted precautionary restrictions on their health and care during the pandemic. Maternity services had to adapt to changing Government guidance. Coupled with the imposition of national lockdowns in England and restrictions on daily activities, women’s experiences of pregnancy, childbirth and the postpartum period, and their access to services, changed rapidly. This study was designed to understand women’s experiences of pregnancy, labour and childbirth and caring for a baby during this time.
Methods
This was an inductive longitudinal qualitative study, using in-depth interviews by telephone with women in Bradford, UK, at three timepoints during their maternity journey (18 women at timepoint one, 13 at timepoint two and 14 at timepoint three). Key topics explored were physical and mental wellbeing, experience of healthcare services, relationships with partners and general impact of the pandemic. Data were analysed using the Framework approach. A longitudinal synthesis identified over-arching themes.
Results
Three longitudinal themes captured what was important to women: (1) women feared being alone at critical points in their maternity journey, (2) the pandemic created new norms for maternity services and women’s care, and (3) finding ways to navigate the COVID-19 pandemic in pregnancy and with a baby.
Conclusions
Modifications to maternity services impacted significantly on women’s experiences. The findings have informed national and local decisions about how best to direct resources to reduce the impact of COVID-19 restrictions and the longer-term psychological impact on women during pregnancy and postnatally.
Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
Authors: Grahn Petra , Remes Tiina , Kivisaari Reetta , Suo-Palosaari Maria H , Arikoski Pekka M , Koskenkorva Päivi K T , Lähteenmäki Päivi M , Lönnqvist Tuula R I , Ojaniemi Marja K , Sirkiä Kirsti H , Sutela Anna K , Toiviainen-Salo Sanna-Maria , Rantala Heikki M J , Harila-Saari Arja H , Niinimäki Jaakko , Karppinen Jaro , Ahonen Matti 
Published: December 2022

Abstract
Background: Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. With an increasing population of childhood BT survivors, the understanding of the long-term consequences of BT treatment is highlighted. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls.
Methods: In this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5–33.1), 67 (mean age 28.4, range 16.2–43.5) survivors were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, high-intensity zone-lesions (HIZ), intervertebral disc protrusions, and extrusions. Groups were also compared for known risk factors of intervertebral disc degeneration.
Results: Childhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p<0.001). Lumbar disc protrusions at L4-5 (p=0.02) and extrusions at L3-4 (p=0.04), L4-5 (p=0.004), and L5-S1 (p=0.01) were significantly more common in the BT group compared to the control group. BP correlated with a higher degree of IVD degeneration at Th12-L1 (p=0.01), L1-2 (p=0.01), and L3-4 (p=0.03). Survivors with a younger age at diagnosis had significantly lower Pfirrmann grades (p<0.01).
Conclusions: Signs of early aging related to tumor treatment can be seen in the intervertebral discs of survivors. Disc degeneration was more severe in children treated in adolescence.