bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flipped Learning 4.0. An extended flipped classroom model with Education 4.0 and organisational learning processes
Authors: Sein-Echaluce María Luisa , Fidalgo-Blanco Ángel , Balbín Ana María , García-Peñalvo Francisco José 
Published: November 2022

AbstractThis article integrates two visions on the creation of knowledge by students: an academic vision where the person who creates knowledge uses high-level cognitive abilities and, therefore, acquires deeper learning, and an organisational learning vision, where the creation of knowledge adds value to the organisation and the individuals who work in this matter. It starts from a validated flipped classroom model and then adds procedures and cycles of knowledge that make it an active methodology, in such a way that it simultaneously supports organisational learning, using cooperative competencies characteristic of Education 4.0. This proposed hybrid model has been applied online during confinement due to the COVID-19 pandemic and, subsequently, in dual mode (students partly in person and the rest online at the same time) and face-to-face mode. The evidence of this research shows that the creation of knowledge by the students, cooperatively and with an organisational learning perspective, has repercussions for improvements in their academic performance by producing deeper learning. In addition, the development of cooperative skills is observed to create and manage a large amount of helpful knowledge for them and other students in their learning process.
Learning across media in a second language
Authors: Tarchi Christian , Mason Lucia 
Published: November 2022

AbstractThe present study investigated the impact of the medium on learning in L2. Specifically, learning performances from L2 material were compared across three media: text, video, and subtitled video. The participants were 126 undergraduate students who were randomly assigned across three conditions: a text condition, a video condition, and a subtitles condition. First, students were asked to complete three questionnaires on control variables. Second, students were asked to read/watch a learning material and answer comprehension, recall, transfer, and calibration questions twice: immediately and a week after. Results reveal that the participants in the video condition outperformed those in the text condition in delayed comprehension and recall. Overall, learning performances were substantially equivalent across media when assessed immediately after processing the material, but subtitled videos had the potential to boost deeper learning performances only in highly skilled learners.
The prognostic effects of circulating myeloid-derived suppressor cells in non-small cell lung cancer: systematic review and meta-analysis
Authors: Bronte Giuseppe , Calabrò Luana , Olivieri Fabiola , Procopio Antonio Domenico , Crinò Lucio 
Published: November 2022

AbstractImmunotherapy is the main standard treatment for non-small cell lung cancer (NSCLC) patients. Immune suppressive cells in tumor microenvironment can counteract its efficacy. Myeloid-derived suppressor cells (MDSCs) include two major subsets: polymorphonuclear (PMN-MDSCs) and monocytic (M-MDSCs). Many studies explored the prognostic impact of these cell populations in NSCLC patients. The aim of this systematic review is to select studies for a meta-analysis, which compares prognosis between patients with high vs low circulating MDSC levels. We collected hazard ratios (HRs) and relative 95% confidence intervals (CIs) in terms of progression-free survival (PFS) or recurrence-free survival (RFS), and overall survival (OS). Among 139 studies retrieved from literature search, 14 eligible studies (905 NSCLC patients) met inclusion criteria. Low circulating MDSC levels favor a better PFS/RFS (HR = 1.84; 95% CI = 1.28–2.65) and OS (HR = 1.78; 95% CI = 1.29–2.46). The subgroup analysis based on MDSC subtypes (total-, PMN-, and M-MDSCs) obtained a statistical significance only for M-MDSCs, both in terms of PFS/RFS (HR = 2.67; 95% CI = 2.04–3.50) and OS (HR = 2.10; 95% CI = 1.61–2.75). NSCLC patients bearing high M-MDSC levels in peripheral blood experience a worse prognosis than those with low levels, both in terms of PFS/RFS and OS. This finding suggests that detecting and targeting this MDSC subset could help to improve NSCLC treatment efficacy.
Immigrant workers and firm resilience on the export market
Authors: Marchal Léa , Sabbadini Giulia 
Published: November 2022

AbstractThis paper studies whether firms employing immigrant workers are more resilient to an increase in competition in their export markets. Exploiting the surge of Chinese imports following its accession to the World Trade Organization and using a sample of French manufacturing exporters from 2002 to 2015, we find that an increase in the growth rate of Chinese competition in a foreign market has a negative effect on both the two-year survival and growth rate of sales of French exporters on that foreign market. This negative effect on firm performance is mitigated by the employment of immigrant workers.
Virulence genes contributing to Aeromonas veronii pathogenicity in Nile tilapia (Oreochromis niloticus): approaching the development of live and inactivated vaccines
Authors: Youssef Hadeer A. , Ayoub Hala F. , Soror Eman I. , Matter Aya F. 
Published: November 2022

AbstractThis study aimed to develop and evaluate live and inactivated vaccines to Aeromonas veronii pathogenicity in Nile tilapia. Therefore, five well-identified Aeromonas veronii isolates, including A (HY1), A (HY2), A (HY3), A (HY4), and A (HY6) isolated from diseased Nile tilapia (Oreochromis niloticus), were used for vaccine preparation. Virulence genes detected by a polymerase chain reaction (PCR) and lethal dose determination were conducted. Nile tilapia, each with a body weight of 25 ± 0.5 g were divided into six experimental groups (each of 20): T1 group (control), fish were injected with saline as a negative control, T2 group (formalin-killed vaccine) for the A (HY2) strain, T3 group ( formalized killed vaccine) for the A (HY4), T4 group (autoclaved vaccine) for the A (HY2), T5 group (autoclaved vaccine) for A (HY4), and T6 (live vaccine) for A (HY1), triplicate. At the end of the immunization period, all groups were challenged by A. veronii, A (HY2). Blood samples were drawn 21 days post-immunization and 3 days after the challenge test for antibody titer assay. The results showed that the pathogenicity of strains A (HY2) and A (HY4) was the strongest, as the lethality rates (LR) were 100% and 90%, respectively, whereas the pathogenicity was moderate for strains A (HY3) and A (HY6) (LR 60% for each). A (AY1) was the weakest strain as no dead fish was found for this strain. The presence of alt, act, aerolysin, lipase, and fla genes as the main cause of the pathogenesis. The best protective efficacy was obtained from the live vaccine, A (HY1) with a protective rate of about 94.12% (relative percentage of survival, RPS), compared to autoclaved killed vaccines and formalin-killed vaccines. Based on immunoglobulin estimation (IgM) and RPS%, our data concluded that A (HY1) live vaccine had the best vaccine prophylactic effect against the highly pathogenic strain A(HY2).
EEG Microstate Dynamics Associated with Dream-Like Experiences During the Transition to Sleep
Authors: Diezig Sarah , Denzer Simone , Achermann Peter , Mast Fred W. , Koenig Thomas 
Published: November 2022

AbstractConsciousness always requires some representational content; that is, one can only be conscious about something. However, the presence of conscious experience (awareness) alone does not determine whether its content is in line with the external and physical world. Dreams, apart from certain forms of hallucinations, typically consist of non-veridical percepts, which are not recognized as false, but rather considered real. This type of experiences have been described as a state of dissociation between phenomenal and reflective awareness. Interestingly, during the transition to sleep, reflective awareness seems to break down before phenomenal awareness as conscious experience does not immediately fade with reduced wakefulness but is rather characterized by the occurrence of uncontrolled thinking and perceptual images, together with a reduced ability to recognize the internal origin of the experience. Relative deactivation of the frontoparietal and preserved activity in parieto-occipital networks has been suggested to account for dream-like experiences during the transition to sleep. We tested this hypothesis by investigating subjective reports of conscious experience and large-scale brain networks using EEG microstates in 45 healthy young subjects during the transition to sleep. We observed an inverse relationship between cognitive effects and physiological activation; dream-like experiences were associated with an increased presence of a microstate with sources in the superior and middle frontal gyrus and precuneus. Additionally, the presence of a microstate associated with higher-order visual areas was decreased. The observed inverse relationship might therefore indicate a disengagement of cognitive control systems that is mediated by specific, inhibitory EEG microstates.
The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast cancer
Authors: Bardia Aditya , Mayer Ingrid , Winer Eric , Linden Hannah M. , Ma Cynthia X. , Parker Barbara A. , Bellet Meritxell , Arteaga Carlos L. , Cheeti Sravanthi , Gates Mary , Chang Ching-Wei , Fredrickson Jill , Spoerke Jill M. , Moore Heather M. , Giltnane Jennifer , Friedman Lori S. , Chow Maneval Edna , Chan Iris , Jhaveri Komal 
Published: November 2022

Abstract
Purpose
GDC-0810 (ARN-810) is a novel, non-steroidal, orally bioavailable, selective estrogen receptor degrader (SERD) that potentially inhibits ligand-dependent and ligand-independent estrogen receptor (ER)-mediated signaling.

Methods
A phase Ia/Ib/IIa dose escalation, combination treatment with palbociclib or a luteinizing hormone-releasing hormone, and expansion study determined the safety, pharmacokinetics, and recommended phase 2 dose (RP2D) of GDC-0810 in postmenopausal women with ER + (HER2 −) locally advanced or metastatic breast cancer (MBC). Baseline plasma ctDNA samples were analyzed to determine the ESR1 mutation status.

Results
Patients (N = 152) received GDC-0810 100–800 mg once daily (QD) or 300–400 mg twice daily, in dose escalation, expansion, as single agent or combination treatment. Common adverse events regardless of attribution to study drug were diarrhea, nausea, fatigue, vomiting, and constipation. There was one dose-limiting toxicity during dose escalation. The maximum tolerated dose was not reached. GDC-0810 600 mg QD taken with food was the RP2D. Pharmacokinetics were predictable. FES reduction (> 90%) highlighting pharmacodynamic engagement of ER was observed. Outcomes for the overall population and for patients with tumors harboring ESR1 mutations included partial responses (4% overall; 4% ESR1), stable disease (39% overall; 42% ESR1), non-complete response/non-progressive disease (13% overall; 12% ESR1), progressive disease (40% overall; 38% ESR1), and missing/unevaluable (5% overall; 5% ESR1). Clinical benefit (responses or SD, lasting ≥ 24 weeks) was observed in patients in dose escalation (n = 16, 39%) and expansion (n = 24, 22%).

Conclusion
GDC-0810 was safe and tolerable with preliminary anti-tumor activity in heavily pretreated patients with ER + advanced/MBC, with/without ESR1 mutations, highlighting the potential for oral SERDs.
Clinical Trial and registration date April 4, 2013. NCT01823835 .
The Importance of Embodiment and Agency in Parents’ Positive Attitudes Towards Shared Reading with Their Children
Authors: Kucirkova Natalia , Grøver Vibeke 
Published: November 2022

AbstractParents’ attitudes are an important indicator of whether and how parents engage in shared book reading (SBR) at home. This study analysed Norwegian parents’ attitudes towards reading books with their children aged between 1–4.5 years. Thematic analysis of data from 24 interviews revealed two main themes in parents’ accounts: agency (the child’s independence, the adult’s control as well as their shared control during SBR) and embodiment (physical presence and intimate experience of a SBR session). Both themes correspond to parents’ preference for reading print rather than digital books with their children. Findings are discussed from the socio-material theoretical perspective, with attention to their practical and policy implications.
Non-propositionalism and the Suppositional Rule
Authors: Beevers Tom 
Published: November 2022

AbstractIt can often seem like the attitude we hold towards a conditional should be our attitude in the consequent on the supposition of the antecedent. Following by Williamson (Suppose and Tell: The Semantics and Heuristics of Conditionals. Oxford University Press, 2020), we call this The suppositional rule (SR). The Adams-style non-propositional theories of indicatives upholds some key implications of SR, allowing, for instance, our credence in a conditional to be the probability of the consequent given the antecedent. Williamson (Suppose and Tell: The Semantics and Heuristics of Conditionals. Oxford University Press, 2020) has recently provided a series of inconsistency arguments against SR. He thereby intends to undermine non-propositional views as well as other rivals to his favoured material conditional account. I outline a strategy which theorists of all stripes can employ to avoid Williamson’s arguments. I then show how non-propositionalists can implement this strategy. I show how they can uphold SR when it is intuitively compelling, whilst allowing it to fail when it is not.
Laboratory variation in the grading of dysplasia of duodenal adenomas in familial adenomatous polyposis patients
Authors: Soons E. , Siersema P. D. , van Lierop L. M. A. , Bisseling T. M. , van Kouwen M. C. A. , Nagtegaal I. D. , van der Post R. S. , Atsma F. 
Published: November 2022

AbstractTo prevent duodenal and ampullary cancer in familial adenomatous polyposis (FAP) patients, a diagnosis of high grade dysplasia (HGD) plays an important role in the clinical management. Previous research showed that FAP patients are both over- and undertreated after a misdiagnosis of HGD, indicating unwarranted variation. We aimed to investigate the laboratory variation in dysplasia grading of duodenal adenomas and explore possible explanations for this variation. We included data from all Dutch pathology laboratories between 1991 and 2020 by retrieving histology reports from upper endoscopy specimens of FAP patients from the Dutch nationwide pathology databank (PALGA). Laboratory variation was investigated by comparing standardized proportions of HGD. To describe the degree of variation between the laboratories a factor score was calculated. A funnel plot was used to identify outliers. A total of 3050 specimens from 25 laboratories were included in the final analyses. The mean observed HGD proportion was 9.4%. The top three HGD-diagnosing laboratories diagnosed HGD 3.9 times more often than the lowest three laboratories, even after correcting for case-mix. No outliers were identified. Moderate laboratory variation was found in HGD diagnoses of duodenal tissue of FAP patients after adjusting for case-mix. Despite the fact that no outliers were observed, there may well be room for quality improvement. Concentration of these patients in expertise centers may decrease variation. To further reduce unwarranted variation, we recommend (inter)national guidelines to become more uniform in their recommendations regarding duodenal tissue sampling and consequences of HGD diagnoses.
A systematic review of student agency in international higher education
Authors: Inouye Kelsey , Lee Soyoung , Oldac Yusuf Ikbal 
Published: November 2022

Abstract The agency of international students has long been neglected and undertheorised, though recent literature indicates that this has started to change. This paper systematically reviews 51 studies that address student agency in international higher education. Focusing on research published in the last two decades (2000–2020), the review draws on studies that foreground student voices, or international students’ perspectives, rather than the perspectives of teachers, administrators or policymakers. A detailed discussion of how international student agency is positioned in the literature found that agency appears as either: a research object, as part of a theoretical or conceptual framework, or an emergent finding. Furthermore, our analysis suggests that the term “agency” is often used as a buzzword rather than as a fleshed-out concept. Thus, drawing on this initial analysis, the review synthesises varying but overlapping conceptualisations of international student agency in the literature into an integrative framework. Implications for future research are drawn, based on our findings about the understudied populations and methodological limitations in the literature.
Responses of Bunias orientalis to Short-term Fungal Infection and Insect Herbivory are Independent of Nutrient Supply
Authors: Binama Blaise , Behrendt Miriam , Müller Caroline 
Published: November 2022

AbstractPlants have to allocate their resources in both growth and defense under different environmental challenges. Several plant species have become invasive particularly in disturbed fertile habitats, which may influence their resource allocation. We studied the effects of nitrate fertilization (low versus high) on various plant responses towards a pathogenic fungus, Alternaria brassicae, and a herbivorous insect species, Mamestra brassicae, in a population of Bunias orientalis, which is invasive in parts of central Europe. Aboveground biomass and leaf trichome density were enhanced in plants under high fertilization. In contrast, the short-term fungal infection and herbivory had no effect on aboveground biomass. Leaf water, nitrogen content and glucosinolate concentrations were neither affected by fertilization nor in response to antagonist attack. The total soluble sugar content, especially fructose, as well as leaf peroxidase activity increased significantly in leaves upon fungal infection, but independent of fertilization. Larval biomass gain and herbivore survival were likewise unaffected by fertilization. Our findings highlight that under conditions of high fertilization, B. orientalis plants allocate more resources into growth and morphological defenses than chemical defenses. In contrast, induced responses to short-term antagonist attack seem independent of nitrate availability in this population.
Green heterogeneous catalysts for cleaner solvent-free production of acetates
Authors: Izquierdo Silvia , Silvero Guadalupe , Durán-Valle Carlos J. , López-Coca Ignacio M. 
Published: November 2022

AbstractThe development of new chemical synthetic methodologies that transform industrial chemical processes into more sustainable ones, constitutes one of the challenges and objectives of chemical research both in academia and in industry. The use of activated carbons as heterogeneous catalysts represents one of the most beneficial options for process efficiency in terms of reaction rate, yield, and ease of work-up. We have produced six new activated carbons by treatment of three affordable commercial carbons with either nitric acid, or with sulfuric acid. The complete characterization of these nine activated carbons has been carried out through the measurement of nitrogen adsorption capacity, porosimetry, elemental organic analysis, X-ray photoelectron spectroscopy, scanning electron microscopy and determination of the point of zero charge; transmission electron microscopy was also performed on two of them. The catalytic activity of these nine catalysts has been tested in the acetylation reaction of hydroxyl groups, undoubtedly one of the most versatile and widely used chemical transformations both at the laboratory and industrial scale. The results show that by means of a simple and affordable modification of commercial xerogel with sulfuric acid, a more efficient catalyst is formed. Acetylation with the best catalyst is completed in 90 min at room temperature and the product is easily isolated in quantitative yield. The system can be reutilized for five runs with only a small loss of catalytic activity.
The Role and Value of Chaplains in an Australian Ambulance Service: A Comparative Study of Chaplain and Paramedic Perspectives
Authors: Tunks Leach Katie , Simpson Paul , Lewis Joanne , Levett-Jones Tracy 
Published: November 2022

AbstractChaplains are embedded in several ambulance services across Australia, however as Australia’s religiosity is currently in decline and questions are being asked about retaining chaplains, little is actually known about their role and value within Ambulance services. The aim of this paper is to present the key findings from interviews with chaplains about their role and value of being ambulance chaplains. These findings are then compared with those of paramedics derived from an earlier phase of this study. Thirteen chaplains participated in semi-structured interviews, and data were analysed using framework analysis. The results indicated that ambulance chaplains provided paramedic-centred emotional and spiritual care through proactively and reactively supporting paramedics in their work. Chaplains saw value in their relational approach which facilitated trust and access, did not seek to ‘fix’ or diagnose but instead offered physical and emotional presence, and promoted supportive conversations. Chaplains and paramedics valued operationally trained and equipped ambulance chaplains who provided a relational, around the clock, ‘frontline’ staff support presence in paramedic workplaces, regardless of the paramedic’s personal religious/spiritual beliefs.