bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redevelopment along arterial streets: The effects of light rail on land use change
Authors: Agustini Kadek Ayu Vergianti , West Sarah E. 
Published: August 2022

AbstractWe use difference‐in‐differences approaches and parcel‐level data from Minneapolis to estimate the effects of light rail on land use change using alternate definitions of treatment area. Results using circular buffers corroborate previous findings that light rail has virtually no effect on land use change in our study area. In contrast, light rail increases the likelihood of land use change along arterial streets that cross the line at station areas. To accurately model the effects of public transit projects on urban land use, one must consider how potential riders access station areas, rather than assuming accessibility improves radially around a station.
Advances in magnetic nanoparticles for the separation of foodborne pathogens: Recognition, separation strategy, and application
Authors: Xiao Fangbin , Li Weiqiang , Xu Hengyi 
Published: August 2022

AbstractFoodborne pathogens contamination is one of the main sources of food safety problems. Although the existing detection methods have been developed for a long time, the complexity of food samples is still the main factor affecting the detection time and sensitivity, and the rapid separation and enrichment of pathogens is still an objective to be studied. Magnetic separation strategy based on magnetic nanoparticles (MNPs) is considered to be an effective tool for rapid separation and enrichment of foodborne pathogens in food. Therefore, this study comprehensively reviews the development of MNPs in the separation of foodborne pathogens over the past decade. First, various biorecognition reagents for identification of foodborne pathogens and their modifications on the surface of MNPs are introduced. Then, the factors affecting the separation of foodborne pathogens, including the size of MNPs, modification methods, separation strategies and separation forms are discussed. Finally, the application of MNPs in integrated detection methods is reviewed. Moreover, current challenges and prospects of MNPs for the analysis of foodborne pathogens are discussed. Further research should focus on the design of multifunctional MNPs, the processing of large‐scale samples, the simultaneous analysis of multiple targets, and the development of all‐in‐one small analytical device with separation and detection.
Select Water Quality Parameters during Wet and Dry Conditions in the Colorado River Delta
Authors: García‐Hernández J. , Leyva‐García G. , Aguilera‐Márquez D. , Díaz‐Argumedo R.E. , Santiago‐Serrano E. , Zamora‐Arroyo F. 
Published: August 2022

ABSTRACTThe Colorado River Delta (CRD) consists of agricultural fields and remnant wetlands that are sustained by the Colorado River and agricultural drainage. Electrical conductivity (EC), dissolved oxygen, and ammonia‐nitrogen data were collected at different locations in the CRD at the end of a wet period in 2000 and compared with the concentrations present during the dry conditions that prevailed from 2001 to 2020. An increase in mean EC values measured by the International Boundary and Water Commission at Morelos Dam between wet (1.2 ± 0.06 mS/cm) and dry (1.4 ± 0.11 mS/cm) periods was observed. The same was also observed at reach 4 of the riparian corridor between the wet (2.4 ± 0.24 mS/cm) and dry (3.3 ± 0.75 mS/cm) periods with an increasing trend in salinity over the years. However, salinity values did not exceed the limits required for the growth of native trees and cattails. A positive result was that EC values at reach 6 and the Hardy River significantly decreased over the past 13 years, this was attributed to inflows from “Arenitas” Water Treatment Plant and its wetland that began operations in 2008. Finally, although severe drought will likely mean water shortages, results indicate that treated water can maintain and restore riparian corridors and wetlands. It is recommended that ongoing conservation efforts consider these local water sources in addition to the ecological pulse flows.
Petrogenesis of the ~1.94 Ga Meta‐gabbronorites in Liangcheng: Implications for Tectonic Evolution of the Khondalite Belt, North China Craton
Authors: LIAN Guanghui , REN Yunwei , SHI Jianrong , XU Zhongyuan , FENG Fan 
Published: August 2022

AbstractWe investigated the meta‐gabbronorites in Liangcheng and used detailed petrography, geochemistry, zircon geochronological and in‐situ Hf isotopic studies to clarify their formation and metamorphic ages, petrogenesis, tectonic setting and provide constraints on the tectonic evolution of Khondalite Belt (KB). The zircon U‐Pb dating results show that the meta‐gabbronorites crystallized at ~1.94 Ga and were metamorphosed at ~1.91–1.89 Ga. They can be subdivided into the low‐Mg and high‐Mg groups. The low‐Mg meta‐gabbronorites contain relatively lower MgO and higher SiO2 contents than high‐Mg meta‐gabbronorites. They are enriched in light rare earth elements and large ion lithophile elements, depleted in high field strength elements, and exhibit positive (high‐Mg meta‐gabbronorites) and negative (low‐Mg meta‐gabbronorites) Sr and Eu anomalies. The zircon in‐situ εHf(t) of meta‐gabbronorites is 0.07–4.12, with Hf model ages (TDM) of 2169–2400 Ma. The meta‐gabbronorites in Liangcheng originated from the asthenospheric mantle and experienced fractional crystallization of olivine, orthopyroxene, clinopyroxene, and plagioclase. They were contaminated by the crustal rocks (mainly khondalite series) during ascent, especially for low‐Mg gabbronorites. The ridge subduction is the most plausible tectonic setting for meta‐gabbronorites, indicating the eastern segment of KB was in a ridge subduction setting at ~1.94 Ga following an orogenic thickening event during a prolonged orogenic process.
Geochronology, Eruption Sequence and Geochemistry of Mid–Late Jurassic Volcanics South of Manzhouli: Petrogenesis and Implications for Mesozoic Tectonic Regime Transformation
Authors: BAI Yuling , WANG Tao , WANG Zongqi , YAN Jie , ZHANG Ai 
Published: August 2022

AbstractTo the south of Manzhouli, Hulunbuir, Inner Mongolia, experienced a tectonic regime transformation from compression to extension in the mid‐Mesozoic. Based on systematic research of the volcanics, petrology, volcanic facies, chronology and geochemistry of rocks in the Buridun area, two stages of volcanics are identified. The first stage named the trachyte series was formed in the late Middle Jurassic (167–163 Ma), its eruption rhythm is pyroxene trachyandesite–trachyandesite–trachyte, and its origin rock is basic volcanics from thickened lower crust, with a tectonic setting in the collision orogeny after the closure of the Mongolia Okhotsk Ocean (MOO). The second stage is a bimodal volcanic rock, formed in the early Late Jurassic (163–160 Ma). The eruption rhythm of basic volcanics in this stage is basaltic andesite–basalt–olivine basalt, which comes from the metasomatized lithospheric mantle, the acidic volcanics of which being characterized by the eruption rhythm of sedimentary‐explosive‐overflow facies, which came from the partial melting of newly formed lower crust, and this shows the characteristics of A‐type granite; the tectonic setting is extension of the lithosphere after collision and closure of the MOO. The changes in the formation age and tectonic setting of the two stages of volcanics demonstrate that the transition time from the compressive system to the extensional system south of Manzhouli is about 163 Ma.
Systemic sclerosis with cerebral infarction and severe stenosis of internal carotid artery and coronary artery: A case report
Authors: Wang Lanjing , Chu Min , Wang Daosheng , Teng Jijun 
Published: August 2022

AbstractSystemic sclerosis (SSc) is a chronic autoimmune disease characterized by microangiopathy, extensive fibrosis and autoantibody production. It is generally believed that microvascular disease is the hallmark of SSc. Macrovascular involvement is not initially considered as a feature of SSc, but its mortality is high, which should not be ignored. Up to the present, SSc patients with cerebral involvement and multiple macrovascular stenosis have been rarely described. We herein report a case of cerebral infarction and severe stenosis of the internal carotid artery and coronary artery associated with SSc.
Anti‐MDA5 and anti‐SSA/Ro52 antibodies double‐positive dermatomyositis overlapping with rheumatoid arthritis‐associated interstitial lung disease: A case report
Authors: Xiong Hong , Tan QianRen , Luo Feng , Yuan XueMei , Ma Wukai , Yao XueMing 
Published: August 2022

AbstractDermatomyositis (DM) is a poorly prognostic autoimmune disease the pathogenesis of which is multifactorial and not clearly defined. DM may be influenced by genes, environment, and immunity. The typical manifestations of DM are Gottron rash, heliotrope rash, rash on the shoulders and buttocks, erythema around fingernails, excessive keratosis of the epidermis, mechanic's hands, and interstitial lung disease (ILD), among others. Anti‐melanoma differentiation‐associated 5 gene (MDA5) antibody has been strongly associated with DM. Furthermore, anti‐SSA/Ro52 antibody has been reportedly associated with DM. A 49‐year‐old woman presented with cough, expectoration, and dyspnea. Relevant examinations revealed elevated levels of muscle enzyme, double‐positive anti‐MDA5 and anti‐SSA/Ro52 antibodies, positive rheumatoid factor, and a high titer of anti‐citrullinated protein antibody. DM overlapping rheumatoid arthritis with ILD was confirmed. We suggest the use of glucocorticoids combined with immunosuppressant therapy, supplemented with gastric and liver protection, and recommend the use of intravenous immunoglobulins and rituximab.
SAR11 clade microdiversity and activity during the early spring blooms off Kerguelen Island, Southern Ocean
Authors: Dinasquet Julie , Landa Marine , Obernosterer Ingrid 
Published: August 2022

AbstractThe ecology of the SAR11 clade, the most abundant bacterial group in the ocean, has been intensively studied in temperate and tropical regions, but its distribution remains largely unexplored in the Southern Ocean. Through amplicon sequencing of the 16S rRNA gene, we assessed the contribution of the SAR11 clade to bacterial community composition in the naturally iron fertilized region off Kerguelen Island. We investigated the upper 300 m at seven sites located in early spring phytoplankton blooms and at one high‐nutrient low‐chlorophyll site. Despite pronounced vertical patterns of the bacterioplankton assemblages, the SAR11 clade had high relative abundances at all depths and sites, averaging 40% (±15%) of the total community relative abundance. Micro‐autoradiography combined with CARD‐FISH further revealed that the clade had an overall stable contribution (45%–60% in surface waters) to bacterial biomass production (determined by 3H‐leucine incorporation) during different early bloom stages. The spatio‐temporal partitioning of some of the SAR11 subclades suggests a niche specificity and periodic selection of different subclades in response to the fluctuating extreme conditions of the Southern Ocean. These observations improve our understanding of the ecology of the SAR11 clade and its implications in biogeochemical cycles in the rapidly changing Southern Ocean.
Lung‐specific exosomes for co‐delivery of CD47 blockade and cisplatin for the treatment of non–small cell lung cancer
Authors: Cui Zhilei , Ruan Zhengshang , Zeng Junxiang , Sun Jinyuan , Ye Wenjing , Xu Weiguo , Guo Xuejun , Zhang Linlin , Song Lin 
Published: August 2022

AbstractA cluster of differentiation 47 (CD47) and immune‐modulatory protein for myeloid cells has been implicated in cisplatin (CDDP) resistance. Exosome delivery of drugs has shown great potential for targeted drug delivery in the treatment of various diseases. In the current study, we explored the approach of co‐delivering CDDP and CD47 antibody with MDA‐MB‐231 cell‐derived exosome 231‐exo (CaCE) and assessed the phagocytosis activity of bone marrow flow cytometry derived macrophages (BMDM) against co‐cultured A549 cells. CD8+ T‐cell proliferation was examined with flow cytometry analysis. In vivo, we used the Lewis lung carcinoma (LLC) tumor‐bearing mouse model and assessed survival rate, tumor weight, phagocytosis, and T‐cell proliferation, as well as cytokine levels in tumors analyzed by enzyme‐linked immunoassay (ELISA). Although co‐administration of CDDP with anti‐CD47 (CDDP and aCD47) showed a significant antitumor effect, CaCE had an even more dramatic anticancer effect in survival rate and tumor weight. We observed increased phagocytosis activity selectively against lung tumor cells in vivo and in vitro with exosome CaCE treatment. CaCE treatment also increased T‐cell proliferation compared to the vehicle treatment and co‐administration groups. Furthermore, immunostimulatory interleukin (IL)‐12p and interferon (IFN)‐γ were increased, whereas transforming growth factor β (TGF‐β) were decreased, indicating the improved CDDP anticancer effect is related to a tumor microenvironmental change. Our study demonstrates a dramatically improved anticancer effect of CDDP when administered by exosome co‐delivery with anti‐CD47.
Portugal: Political Developments and Data in 2021
Authors: MAGONE JOSÉ M. 
Published: August 2022

AbstractIn 2021, Portuguese politics was strongly affected by the Covid‐19 pandemic. In this constraining context, the Portuguese population went twice to the polls in presidential and local elections. Moreover, the Portuguese government was the holder of the presidency of the Council of the European Union. Throughout the year, the Portuguese government negotiated with the political parties to get the 2022 budget approved. However, most opposition parties rejected the budget for different reasons. Therefore, the President of the Republic dissolved Parliament and announced early elections for 30 January 2022. Although it was a difficult year, Portugal was able to implement an aggressive vaccination programme, which led to a high vaccination coverage of 80 per cent of the population.
Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model
Authors: Ataei Ataabadi Ehsan , Golshiri Keivan , Jüttner Annika A. , de Vries René , Van den Berg‐Garrelds Ingrid , Nagtzaam Nicole M. A. , Khan Hina N. , Leijten Frank P. J. , Brandt Renata M. C. , Dik Willem A. , van der Pluijm Ingrid , Danser A. H. Jan , Sandner Peter , Roks Anton J. M. 
Published: August 2022

AbstractDNA damage is a causative factor in ageing of the vasculature and other organs. One of the most important vascular ageing features is reduced nitric oxide (NO)soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signaling. We hypothesized that the restoration of NO‐sGC‐cGMP signaling with an sGC activator (BAY 54–6544) may have beneficial effects on vascular ageing and premature death in DNA repair‐defective mice undergoing accelerated ageing. Eight weeks of treatment with a non‐pressor dosage of BAY 54–6544 restored the decreased in vivo microvascular cutaneous perfusion in progeroid Ercc1∆/− mice to the level of wild‐type mice. In addition, BAY 54–6544 increased survival of Ercc1∆/− mice. In isolated Ercc1∆/− aorta, the decreased endothelium‐independent vasodilation was restored after chronic BAY 54–6544 treatment. Senescence markers p16 and p21, and markers of inflammation, including Ccl2, Il6 in aorta and liver, and circulating IL‐6 and TNF‐α were increased in Ercc1∆/−, which was lowered by the treatment. Expression of antioxidant genes, including Cyb5r3 and Nqo1, was favorably changed by chronic BAY 54–6544 treatment. In summary, BAY 54–6544 treatment improved the vascular function and survival rates in mice with accelerated ageing, which may have implication in prolonging health span in progeria and normal ageing.
Campaign Messages, Polling, and Elections: Theory and Experimental Evidence
Authors: Feltovich Nick , Giovannoni Francesco 
Published: August 2022

AbstractHow do politicians’ track records and campaign messaging interact and affect voters’ welfare? We analyze this question theoretically and experimentally. In the theoretical model, which we implement in the experiment, politicians choose how much of an economy's resources to allocate to the citizenry—keeping the remainder for themselves—and then face reelection against a challenger. Both incumbents and challengers have private information about their own quality that determines the economy's level of resources. We vary whether candidates can send campaign messages and the level of variability in candidates’ quality. We observe that both higher‐quality variability and allowing campaigning benefit citizens by allowing them to better select and hold accountable higher‐quality officials. Also, when incumbents have performed poorly or when quality variability is high, challengers’ negative campaigning (criticizing the incumbent) increases and incumbents’ positive campaigning (emphasizing their own strengths) decreases.
Increased sperm deoxyribonucleic acid damage leads to poor embryo quality and subfertility of male rats treated with methylphenidate hydrochloride in adolescence
Authors: da Costa Nunes Gomes Ana Clara , Bellin Camila Souza , da Silva Dias Stephanie , de Queiroz de Rosa Thalita , de Araújo Marina Pereira , Miraglia Sandra Maria , Mendes Talita Biude , Vendramini Vanessa 
Published: August 2022

AbstractBackgroundMethylphenidate hydrochloride (MPH) is a psychostimulant widely used in the treatment of attention‐deficit hyperactive disorder (ADHD), as well as a performance enhancer, for at least 60 years. Despite the notable effectiveness as a psychostimulant, ADHD is a chronic disorder and has a two‐third chance of accompanying the individual throughout life. Long‐term use of MPH has been associated not only with an increase in the development of neurodegenerative diseases, but it also causes side effects on male fertility in experimental animals.ObjectivesTo investigate whether methylphenidate poses a risk to sperm DNA structure and to the quality of embryos conceived after treatment during adolescence in rats.Materials and methodsWistar rats at 38 days of age were treated either with 5 mg/kg body weight of MPH, in a single daily dose for 30 days, via gavage or with distilled water‐only protocol. Levels of oxidative stress in testicular and epididymal tissues were evaluated. Sperm chromatin quality and acrosome integrity was assessed under flow cytometry. From 107 days of age, animals were mated with untreated females. The effects of the paternal contribution at two different embryo development moments—cleavage stage (2.5 days post coitum) and late gestation (20 days post coitum) —were analyzed.ResultsMPH caused high levels of sperm DNA damage, which was reflected in 40% of decrease in early embryo quality and a lower number of live pups at 20 dpc.DiscussionThe high level of fragmentation seen in the embryos sired from the MPH group is consistent with the poor chromatin structure of the sperm and does not seem to be a result of oxidative stress in the reproductive tissues.ConclusionsThe results presented here suggest that the subchronic use of MPH during male prepubertal phase may cause long‐term subfertility and compromise embryo survival.
CSR practices and Sustainable Development Goals: Exploring the connections in Indian context
Authors: Satapathy Jayadev , Paltasingh Tattwamasi 
Published: August 2022

AbstractThere was a growing realization that Millennium Development Goals (MDGs) are overarching, ambitious, complex, and less impactful. Consequently, the 193 member countries of the United Nations (UN) came out with Sustainable Development Goals (SDGs) as a well‐thought‐out global development agenda in the year 2015. By involving the private sectors in the designing of SDGs, UN has rightly identified their potentials in offering solutions to the most relevant sustainability challenges. SDGs came into force in January 2016 across the globe when corporate social responsibility (CSR) was already legalized in India. There has been a whooping investment of approximately Rs. 15,000 crores by nearly 20,000 companies every year under CSR in the country. However, it is argued that the contributions to SDGs are not substantial. Based on review of relevant literature, the current paper makes a modest attempt to explore the connections between CSR and SDGs in contemporary India. Further, it critically examines how CSR in India contributes to SDGs. The paper also analyses the underlying reasons for the inadequate engagement of CSR with SDGs. Despite CSR practices in India having linkage with the SDGs, the outcomes are not as per the expectation as a number of firms operate with less involvement and strategic efforts.
Prevalence of NSAID use among people with COVID‐19 and the association with COVID‐19‐related outcomes: Systematic review and meta‐analysis
Authors: Zhao Huilei , Huang Shanshan , Huang Shan , Liu Fuwei , Shao Wen , Mei Kaibo , Ma Jianyong , Jiang Yuan , Wan Jingfeng , Zhu Wengen , Yu Peng , Liu Xiao 
Published: August 2022

AimRecent reports of potential harmful effects of nonsteroidal anti‐inflammatory drugs (NSAIDs) in treating patients with coronavirus disease 2019 (COVID‐19) have raised great concern.MethodsWe searched the PubMed, EMBASE, Cochrane Library and MedRxiv databases to examine the prevalence of NSAID use and associated COVID‐19 risk, outcomes and safety.ResultsTwenty‐five studies with a total of 101 215 COVID‐19 patients were included. Prevalence of NSAID use among COVID‐19 patients was 19% (95% confidence interval [CI] 14‐23%, no. of studies [n] = 22) and NSAID use prior to admission or diagnosis of COVID‐19 was not associated with an increased risk of COVID‐19 (adjusted odds ratio [aOR] = 0.93, 95% CI 0.82‐1.06, I2 = 34%, n = 3), hospitalization (aOR = 1.06, 95% CI 0.76‐1.48, I2 = 81%, n = 5), mechanical ventilation (aOR = 0.71, 95% CI 0.47‐1.06, I2 = 38%, n = 4) or length of hospital stay. Moreover, prior use of NSAIDs was associated with a decreased risk of severe COVID‐19 (aOR = 0.79, 95% CI 0.71‐0.89, I2 = 0%, n = 7) and death (aOR = 0.68, 95% CI 0.52‐0.89, I2 = 85%, n = 10). Prior NSAID administration might also be associated with an increased risk of stroke (aOR = 2.32, 95% CI 1.04‐5.2, I2 = 0%, n = 2), but not myocardial infarction (aOR = 1.49, 95% CI 0.25‐8.92, I2 = 0, n = 2) and composite thrombotic events (aOR = 1.56, 95% CI 0.66‐3.69, I2 = 52%, n = 2).ConclusionBased on current evidence, NSAID use prior to admission or diagnosis of COVID‐19 was not linked with increased odds or exacerbation of COVID‐19. NSAIDs might provide a survival benefit, although they might potentially increase the risk of stroke. Controlled trials are still required to further assess the clinical benefit and safety (e.g., stroke and acute renal failure) of NSAIDs in treating patients with COVID‐19.