bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfacial Cladding Engineering Suppresses Atomic Thermal Migration to Fabricate Well‐Defined Dual‐Atom Electrocatalysts
Authors: Leng Kunyue , Zhang Jianting , Wang Yi , Li Dingding , Bai Lei , Shi Jingbo , Li Xiaolin , Zheng Lirong , Bai Jinbo , Qu Yunteng 
Published: July 2022

AbstractAs an emerging frontier, dual‐atom catalysts (DACs) have sparked broad interest in energy catalysis, however the undesired thermal atomic migration during synthesis process pose significant challenge in enabling further applications. Herein, an interfacial cladding strategy is reported to construct monodispersed dual‐atom metal sites (metal = Fe, Cu, or Ir), derived from metal dimer molecule functionalized metal‐organic frameworks. First, metal dimer molecule is immobilized at the surface of cubic ZIF‐8 by the interfacial cladding of polydopamine, thus preventing the potentially thermal migration of metal atoms during pyrolysis. Then, the paired metal atoms are anchored onto a hollow carbon nanocage and achieve nitrogen coordinated dual‐atom metal sites after annealing at 900 °C. Representatively, the resultant dual Fe catalysts exhibit remarkable activity for electrocatalytic oxygen reduction reaction with half‐wave potential of 0.951 and 0.816 V in alkaline and acidic media, respectively. The findings open up an avenue for the rational design of dual‐atom catalysts.
Photoinitiator‐Free Two‐Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication
Authors: Nakayama Atsushi , Kumamoto Yasuaki , Minoshima Masafumi , Kikuchi Kazuya , Taguchi Atsushi , Fujita Katsumasa 
Published: July 2022

AbstractTwo‐photon polymerization is expected to realize the fabrication of biological tissues for regenerative medicine and drug development because of its capability of 3D fabrication with submicrometer spatial resolution. However, photopolymerization initiators generally added to resins have low biocompatibility and water solubility, which pose a challenge for the biological application of micro‐ and nanostructures fabricated by photopolymerization. In this study, two‐photon polymerization is performed using biocompatible materials without photoinitiators and the preservation of the material properties of the fabricated 3D structures is evaluated. Poly(ethylene glycol) diacrylate (PEGda) and collagen are successfully fabricated using a femtosecond pulsed laser at a wavelength of 400 nm with a feature size of 100 nm without photoinitiator. The excitation intensities required for the polymerization of PEGda and collagen are about 450 and 150 kW cm−2, respectively, which are smaller than those reported with using photoinitiators. Raman spectroscopy is used to confirm that the water‐swelling polymer network of PEGda and the enzymatic degradation of collagen, which are important factors in the application with live cells, are maintained in the fabricated structures.
Organic Hollow Microstructures with Room Temperature Phosphorescence
Authors: Wang Jiamin , Shen Jing , Zhang Shasha , Gao Yanhua , Song Zhicheng , Yin Chengzhu , Lu Song , Ye Wenpeng , Liu Kun , Ma Huili , Yao Wei , Shi Huifang , An Zhongfu , Huang Wei 
Published: July 2022

AbstractMolecular self‐assembly into hollow microstructures has great potential in catalysis, drug delivery, sensors, and nanoreactors. In contrast to well‐studied fluorescent hollow microstructures, the assembly of phosphorescent hollow microstructures has not yet been fully demonstrated. Here, two types of hollow microstructures based on organic room temperature phosphorescence (RTP) materials are prepared through a convenient vapor‐phase growth method. The observation of the assembly process and the calculations of surface energy reveal that thermodynamically driven Ostwald ripening process plays an essential role in the formation of tunable hollow structures. The universality of this growth technique for hollow microstructures is further demonstrated in various materials and even composites. Compared with non‐hollow structures, the phosphorescent hollow microstructures exhibit high sensitivity to oxygen, indicating the potential of organic hollow microstructure with RTP.
Design of a Split Ring Resonator Integrated with On‐Chip Terahertz Waveguides for Colon Cancer Detection
Authors: Park Sae June , Tucker Robyn , Pickwell‐MacPherson Emma , Cunningham John E. 
Published: July 2022

AbstractFinite element method (FEM) simulations (employing ANSYS High Frequency Structure Simulator, HFSS) are used to investigate the response of terahertz (THz) frequency range split‐ring resonators (SRRs) integrated with on‐chip THz waveguides to cancerous tissues. Two‐port S‐parameter simulations are performed to obtain the transmission spectra (S21) of a planar Goubau line (PGL) integrated with an SRR. Permittivity and loss tangent of the colonic tissues are both taken into account in the numerical simulation. The transmission spectra of the SRR integrated PGL are obtained for cancerous and healthy tissues in close proximity to the SRR, and it is found that they can be distinguished by the resonant frequency shift of the SRR induced by dielectric loading. The electric field distribution and magnitude near the SRR for various capacitive gap widths of SRR are investigated to understand how the gap width affects the maximum electric field magnitude and the vertical extent of the electric field in the gap area. The simulated imaging of colonic tissue consisting of healthy and cancerous tissues using the SRR integrated PGL device with a protective layer on it is performed, showing how the technique could in principle be used to distinguish tumor margins with realistic THz dielectric parameters.
Effect of surface curvature and wettability on nucleation of methane hydrate
Authors: Li Mengyang , Fan Shuanshi , Wang Yanhong , Lang Xuemei , Li Gang , Wang Shenglong , Yu Chi 
Published: July 2022

AbstractNatural gas hydrate nucleation is a complex physical and chemical process that is not well understood presently. In this article, an improved thermodynamic model is proposed to analyze the effects of surface curvature and wettability on methane hydrate nucleation for the first time. The results indicate that methane hydrate nucleation is more difficult on hydrophilic curvature surfaces under the same conditions, with a larger critical nucleation radius and required energy barrier than on hydrophobic surfaces. Furthermore, a convex surface is more favorable for forming methane hydrate under the same conditions than a concave surface. The model's results are critical in elucidating the microscopic mechanism of methane hydrate nucleation and providing a theoretical foundation for developing technologies for strengthening and inhibiting hydrate formation.
Functional validation of novel variants in B4GALNT1 associated with early‐onset complex hereditary spastic paraplegia with impaired ganglioside synthesis
Authors: Alecu Julian Emanuel , Ohmi Yuhsuke , Bhuiyan Robiul H. , Inamori Kei‐ichiro , Nitta Takahiro , Saffari Afshin , Jumo Hellen , Ziegler Marvin , de Gusmao Claudio Melo , Sharma Nutan , Ohno Shiho , Manabe Noriyoshi , Yamaguchi Yoshiki , Kambe Mariko , Furukawa Keiko , Sahin Mustafa , Inokuchi Jin‐ichi , Furakawa Koichi , Ebrahimi‐Fakhari Darius 
Published: July 2022

AbstractChildhood‐onset forms of hereditary spastic paraplegia are ultra‐rare diseases and often present with complex features. Next‐generation‐sequencing allows for an accurate diagnosis in many cases but the interpretation of novel variants remains challenging, particularly for missense mutations. Where sufficient knowledge of the protein function and/or downstream pathways exists, functional studies in patient‐derived cells can aid the interpretation of molecular findings. We here illustrate the case of a 13‐year‐old female who presented with global developmental delay and later mild intellectual disability, progressive spastic diplegia, spastic‐ataxic gait, dysarthria, urinary urgency, and loss of deep tendon reflexes of the lower extremities. Exome sequencing showed a novel splice‐site variant in trans with a novel missense variant in B4GALNT1 [NM_001478.5: c.532‐1G>C/c.1556G>C (p.Arg519Pro)]. Functional studies in patient‐derived fibroblasts and cell models of GM2 synthase deficiency confirmed a loss of B4GALNT1 function with no synthesis of GM2 and other downstream gangliosides. Collectively these results established the diagnosis of B4GALNT1‐associated HSP (SPG26). Our approach illustrates the importance of careful phenotyping and functional characterization of novel gene variants, particularly in the setting of ultra‐rare diseases, and expands the clinical and molecular spectrum of SPG26, a disorder of complex ganglioside biosynthesis.
Lowering the curing shrinkage of epoxy acrylate‐based photosensitive resins through nano‐TiO2 particle with surface grafted by thiol‐terminated hyperbranched polymer
Authors: Li Jingjing , Cui Yihua , Wu Kangle , Sun Chuangchuang 
Published: July 2022

AbstractUV curing three‐dimensional printing (3DP) technology has been developing rapidly due to its high molding accuracy and low cost. However, the curing shrinkage rate of the existing UV curing 3DP materials is still high. The use of inorganic particles to reduce the curing shrinkage of 3D printing materials has received more and more attention in recent years, but the poor dispersibility of inorganic particles in the photosensitive resins has not been effectively solved. In this paper, nano‐TiO2 particles were treated by KH570 in advance and the surface of which were grafted by thiol‐terminated hyperbranched polymer (THBP), hereby THBP@TiO2 was obtained. The results showed that by incorporating of 5 wt% THBP@TiO2, the volume shrinkage rate of epoxy acrylate (EA)‐based photosensitive resins decreased from 8.95% to 4.18%. The THBP@TiO2 combined the anti‐shrinkage mechanism of thiol‐based hyperbranched polyester with that of and inorganic nanoparticles. Otherwise, surface grafting of THBP may effectively improve the dispersibility of nano‐TiO2 particles in EA‐based photosensitive resin by reducing the nano‐TiO2 particles surface energy, and increase the load transfer capacity. The impact strength of 5 wt% THBP@TiO2 modified photosensitive resin increased from 11.2 to 18.1 kJ/m2.
Development of conductive polymeric nanofiber patches for cardiac tissue engineering application
Authors: Mousa Hamouda M. , Ali Mustafa Ghazali , Rezk Abdelrahman I. , Nasr Emad Abouel , Hussein Kamal Hany 
Published: July 2022

AbstractElectrically conductive patches using biocompatible polymeric nanofibers have a beneficial effect on electroresponsive tissues such as the brain, heart, and nervous system. Recently, conductive nanofiber patches with electromechanical properties gained more attention as a promising and a well‐effective technology in tissue engineering due to their conductive and flexible nature. In the present study, proposed conductive nanofibrous patches were developed using the electrospinning technique to mimic native myocardial extracellular matrix (ECM) biological and mechanical properties. Different patches of polyurethane (PU) and polylactic acid (PLA) biopolymer were developed by blending and dual syringe electrospinning followed by coating with interfacial polymerization of polyaniline (PANI). The developed nanofibrous patches were evaluated in terms of morphology, physicochemical properties, mechanical flexibility, and in vitro biocompatibility using human EA. hy926 endothelial cells. Results indicated an appropriate surface wettability and mechanical stability of the developed patches compared to reported human myocardium tissue properties. In addition, the electrochemical impedance spectroscopy (EIS) test showed that patches coated with PANI as conductive films can enhance conductivity compared to the non‐conductive (i.e pure polymers) and resulted in better cell proliferation and attachment. Interestingly, the electrical stimulation (ES) during in vitro test can be electrically stimulated and promote cell proliferation as well as mimic the myocardium bioelectricity. Our findings showed that the developed conductive patches can provide a robust conductive system for electroresponsive tissue indicated by cell proliferation shown in FESEM images of attached cells.
Enantiomeric composition of natural pericosine A derived from Periconia byssoides and α‐glycosidase inhibitory activity of (−)‐enantiomer
Authors: Usami Yoshihide , Nakamura Kimika , Mizobuchi Yoshino , Mizuki Koji , Harusawa Shinya , Yoneyama Hiroki , Yamada Takeshi 
Published: July 2022

AbstractChiral high‐performance liquid chromatography (HPLC) analysis of natural pericosine A, which appeared in literature first in 1977, from Periconia byssoides was conducted using a column CHIRALPAK® AD‐H to determine the enantiomeric composition of the original mixture which was found to be 68: 32 mixtures of (+)‐ and (−)‐enantiomer, respectively. Furthermore, two independently isolated samples of pericosine A from the same fungus were also analyzed to show the two peaks in the HPLC charts at approximate 1:1 ratio. These results concluded that pericosine A derived from Periconia byssoides was indeed an enantiomeric mixture. Synthesized enantiomers were subjected to evaluation of antitumor activity against three kinds of tumor cells (p388, L1210, HL‐60), indicating moderate cytotoxicity against all three kinds of tumor cell lines, but significant difference in potency between the enantiomers was not observed. In contrast, when both the enantiomers of pericosine A were evaluated against five kinds of glycosidases‐inhibitory activities (α‐ and β‐glucosidases, α‐ and β‐galactosidases, and α‐mannosidase), an apparent difference on anti‐glycosidase assay was found between the enantiomers: (−)‐pericosine A inhibited α‐glucosidase at IC50: 2.25 mM, and β‐galactosidase at IC50: 5.38 mM, albeit the (+)‐enantiomer showed inactivity against these five enzymes.
Object detection and estimation: A hybrid image segmentation technique using convolutional neural network model
Authors: Sundaram Aarthi , Sakthivel Chitrakala 
Published: July 2022

SUMMARYObject detection from image is more challenging and integral part in the inter‐discipline area of computer vision. The computer vision is highly attractive in many applications like human pose estimation, instance segmentation, recognizing action, disease predictions object prediction and many more applications. The traditional method of detecting objects from the images is done using bounding boxes with labels. It suffers from the overlapping of the boxes with various smaller objects, which leads to accuracy issues in detection problems. Hence, machine learning techniques are used to detect the relevant objects from the image using center point to avoid the nonmaximal suppression in bounding box. To accurately identify images, an U‐Net architecture based object detection method is proposed. In this model, it effectively uses semantic level segmentation and instance segmentation. This system effectively identifies all the objects present in the given image using the efficient hybrid segmentation models and Gromov Hausdroff distance measure. For experimentation, two data sets are used for evaluation of the model to identify all categories of objects from the image. The proposed model achieves an accuracy of 91.8% and reliable when compared to existing effective object detection algorithms like fully convolution network (FCN), YOLO (you only look once) and mask region based‐convolutional neural network (mask R‐CNN) model.
Clinical utility of the Diagnostic Criteria for Psychosomatic Research for a comprehensive assessment of the elderly
Authors: Mansueto Giovanni , Romanazzo Sara , Cosci Fiammetta 
Published: July 2022

AbstractIntroductionAccording to the revised version of the Diagnostic Criteria for Psychosomatic Research (DCPR‐R), this study explored the prevalence and clinical correlates of DCPR‐R psychosomatic syndromes in the elderly and tested whether DCPR‐R provide an incremental contribution to the prediction of psychosocial functioning over and above DSM‐5.MethodOne hundred seven elderly subjects were recruited. Participants received a clinical assessment, which included the DCPR‐Revised Semi‐Structured Interview (DCPR‐R SSI), the Structured Clinical Interview for DSM‐5‐Clinician Version (SCID‐5‐CV), the Psychological Well‐Being (PWB) Scales, the Geriatric Anxiety Scale (GAS) and the Geriatric Depression Scale (GDS). Analyses of covariance (ANCOVA) and hierarchical regression analyses were run.ResultsTwenty‐two (20.6%) subjects had at least one DSM‐5 diagnosis, and 62 (57.9%) reported at least one DCPR‐R diagnosis. Subjects with at least one DCPR‐R diagnosis showed lower PWB Personal Growth and PWB Purpose in Life than those without DCPR‐R diagnoses. When the incremental validity of the DCPR‐R was tested using PWB Personal Growth, PWB Purpose in Life, PWB Self‐acceptance, GAS Cognitive symptoms and GAS affective symptoms subscales as criterion variable, the DCPR‐R increased up to 0.135–0.263 the explained variance.ConclusionThe DCPR‐R might be implemented together with the DSM‐5 to have a comprehensive assessment of elderly subjects.
Change processes in psychotherapy for patients presenting with histrionic personality disorder
Authors: Babl Anna , Gómez Penedo Juan Martín , Berger Thomas , Schneider Noemi , Sachse Rainer , Kramer Ueli 
Published: July 2022

AbstractObjectiveHistrionic personality disorder (HPD) with a lifetime prevalence rate of 1.8% is an under‐researched psychiatric diagnosis. The present study therefore aimed to investigate both the processes and outcomes of psychotherapy for HPD in a non‐controlled study.MethodsA total of 159 patients diagnosed with HPD were recruited and received clarification‐oriented psychotherapy. Sessions 15, 20, and 25 were video‐recorded and analysed using the Process‐Content‐Relationship Scale. Therapy outcome was assessed with symptom measures at intake and discharge. Hierarchical linear modelling was applied to estimate the changes in the psychotherapeutic outcome and associations with patient and therapist process developments.ResultsImprovements in relationship processes of patients and therapists were systematically related to outcome while only partial relationships were found on the levels of process and content.ConclusionThe present study represents the first systematic insight into core changes in patients with HPD undergoing psychotherapy.
Dinuclear Ruthenium(II)‐Pyrrolide Complexes Linked by Different Organic Units as PDT Photosensitizers: Computational Study of the Linker Influence on the Photophysical Properties*
Authors: Butera Valeria , Mazzone Gloria , Detz Hermann 
Published: July 2022

AbstractA new family of bis[pyrrolyl Ru(II)] triad scaffolds, consisting of two [Ru(bpy)2]2+ centers separated by a variety of organic linkers, has been recently reported as efficient compounds for in vitro photodynamic therapy (PDT). Among all the complexes, the one carrying the pyrenyl group in the organic linker, namely 4 h, has emerged as an extremely potent photosensitizer for in vitro PDT. Here, we present a computational study based on both DFT and TDA‐TDDFT methods, to investigate the photochemical properties of this promising complex. In order to evaluate the influence of the organic chromophore on the photochemical properties, our investigation was further extended to the complex 4 e, whose linker includes the benzothiadiazole group, which has yielded the longest‐wavelength absorption maxima overall (but with a reduced intensity compared to 4 h). Eventually, the role of the second [Ru(bpy)2]2+ moiety was evaluated by comparison with the mononuclear complex.
A pilot clinical trial of cell therapy in heart failure with preserved ejection fraction
Authors: Vrtovec Bojan , Frljak Sabina , Poglajen Gregor , Zemljic Gregor , Cerar Andraz , Sever Matjaz , Haddad Francois , Wu Joseph C. 
Published: July 2022

AimsWe investigated the effects of CD34+ cell therapy in patients with heart failure with preserved ejection fraction (HFpEF).Methods and resultsIn a prospective pilot study, we enrolled 30 patients with HFpEF. In Phase 1, patients were treated with medical therapy for 6 months. Thereafter, all patients underwent CD34+ cell transplantation. Using electroanatomical mapping, we measured local mechanical diastolic delay and myocardial viability to guide the targeting of cell injections. Patients were followed for 6 months after cell transplantation (Phase 2), and the primary endpoint was the difference in change in E/e′ between Phase 1 and Phase 2. In Phase 1, the decrease in E/e′ was significantly less pronounced than in Phase 2 (−0.33 ± 1.72 vs. −3.77 ± 2.66, p = 0.001). During Phase 1, there was no significant change in global systolic strain (GLS; from −12.5 ± 2.4% to −12.8 ± 2.6%, p = 0.77), N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP; from 1463 ± 1247 pg/ml to 1298 ± 931 pg/ml, p = 0.31), or 6‐min walk test (6MWT; from 391 ± 75 m to 402 ± 93 m, p = 0.42). In Phase 2, an improvement was noted in NT‐proBNP (from 1298 ± 931 pg/ml to 887 ± 809 pg/ml, p = 0.02) and 6MWT (from 402 ± 93 m to 438 ± 72 m, p = 0.02). Although GLS did not change significantly in Phase 2 (from −12.8 ± 2.6% to −13.8 ± 2.7%, p = 0.36), we found improved local systolic strain at cell injection sites (−3.4 ± 6.8%, p = 0.005).ConclusionsIn this non‐randomized trial, transendocardial CD34+ cell therapy in HFpEF was associated with an improvement in E/e′, NT‐proBNP, exercise capacity, and local myocardial strain at the cell injection sites.Clinical Trial Registration: ClinicalTrials.gov NCT02923609.
Phosphorescent Cyclometalated Platinum(ii) Hexahydroimidazo[1,5‐a]pyridinylidene Complexes
Authors: Stipurin Sergej , Strassner Thomas 
Published: July 2022

AbstractThe synthesis of N‐heterocyclic carbene precursors based on the hexahydroimidazo[1,5‐a]pyridine and their corresponding cyclometalated platinum(II) carbene complexes is reported. All compounds are fully characterized by standard techniques and additionally X‐ray structures could be obtained for three complexes. The photophysical properties of these platinum complexes were investigated by absorption and photoluminescence measurements. All complexes showed strong phosphorescence at room temperature in the sky‐blue area with quantum yields of up to 71 %. Additionally, their electrochemical properties were examined by voltammetry experiments. All results were rationalized by quantum chemical DFT calculations (PBE0/6‐311G*).