bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ruthenium(II)‐Catalyzed (4+2) Annulative Difunctionalization of Non‐conjugated Alkenyl Amides with Hydroxamic Acid Esters
Authors: Kumar Giri Chandan , Dana Suman , Baidya Mahiuddin 
Published: September 2022

AbstractRu(II)‐catalyzed C−H bond activation strategy has been capitalized through a (4+2) annulative difunctionalization of non‐conjugated alkenyl amides. Under mild conditions, a broad range of (hetero)aromatic amides embedded with NH−OMe unit as an internal oxidant produced high‐value dihydroisoquinolinone scaffolds in good to excellent yields. This heteroannulation is also effective with acrylamides to dispense dihydro‐2‐pyridones and accommodates bioactive scaffolds such as tocopherol, estrone, and amino acids.
Chloridumverteilung in gerissenen und mit Prinzip 8.3 (W‐Cl) instand gesetzten Stahlbetonbauteilen
Authors: Osterminski Kai , Zausinger Christoph , Gehlen Christoph 
Published: September 2022

AbstractDie Applikation eines Oberflächenschutzsystems befahrener korrosionsgefährdeter Stahlbetonbauteile wird seit vielen Jahren im Rahmen des nach TR Instandhaltung [3] definierten Prinzips 8.3 (W‐Cl) angewandt. Die damit erreichbare Wirkung dieses Instandsetzungsprinzips ist nach wie vor schwer einzuschätzen, da sowohl der zeitliche Verlauf der von verschiedenen Einflüssen abhängigen Korrosionsaktivität als auch die Chloridumverteilung infolge der Beschichtung nicht eindeutig bestimmt sind. Der Fokus der vorliegenden Arbeit liegt auf der dreidimensionalen zeitabhängigen Erfassung der Chloridumverteilung nach dreimonatiger, damit kurzzeitiger, intermittierender Tausalzkontamination bewehrter gerissener Betonbalken und anschließender Beschichtung. Nach dieser Kurzzeitexposition wurden die Risse beschichtet und über einen Zeitraum von 18 Monaten insgesamt 160 Chloridprofile aus dem chloridbelasteten Rissbereich des Betons entnommen. Die Versuchsmatrix umfasste dabei sowohl Biege‐ als auch Trennrisse sowie CEM‐I‐ und CEM‐III‐Betone. Die tiefenabhängigen Chloridgehalte aus der Bohrmehlentnahme der baupraktisch üblichen Blindprofile (über dem Riss senkrecht gebohrt) wurden durch die Chloridgehalte der Profile entlang der nachträglich offengelegten Rissflanken bestätigt. Zusätzlich konnte senkrecht zur Rissflanke kein signifikanter Einfluss der Grenzfläche zwischen Beton und Bewehrung gegenüber unbewehrtem Beton als begünstigender oder limitierender Faktor ausgemacht werden. Da bei den meisten Profilen am Ende des Untersuchungszeitraums von 18 Monaten in unmittelbarer Nähe zum Riss immer noch Chloridgehalte über 0,5 M.‐%/z. vorlagen, ist, zunächst nur Informationen zum Chloridgehalt in Betracht ziehend, aktive Korrosion nach wie vor nicht auszuschließen.
Teaching calculus in the first year of an engineering degree using a Digital Escape Room in an online scenario
Authors: Magreñán Ángel Alberto , Jiménez Cristina , Orcos Lara , Roca Simón 
Published: September 2022

AbstractIn recent years, the way in which mathematics is taught has changed radically and there has been an increase in the percentage of online classes. One of the biggest challenges that teachers face in this type of online scenario is the need to motivate students so that they do not lose the thread and continue with their usual rhythm and seek methodologies that facilitate the teaching–learning process. The growth of educational technology has become a powerful ally in carrying out this study. This study presents the use of a digital Escape Room in an online scenario for teaching mathematics in the first course of engineering. To measure the results, a pretest–posttest experience has been considered with two different groups of the first course of engineering in an online university. Some comparison tests of the qualifications obtained by both groups shows that, despite they were homogeneous in terms of previous knowledge of calculus in the beginning, the differences obtained between those who have used the Escape Room instead of the traditional methodology are significative. In addition, the effect sizes obtained were intermediate and also considering the results of the survey allows us to conclude that the use of the digital Escape Room is a very good tool for teaching Calculus in Engineering. Finally, it is also important to highlight that the satisfaction of the student with respect to the experience has been very high and they asked for more experiences like this.
A pyroptosis‐related signature predicts prognosis and indicates immune microenvironment infiltration in glioma
Authors: Chen Jia , Chen Shanwei , Li Bingxian , Zhou Shaojiong , Lin Han 
Published: September 2022

AbstractBackgroundGlioma, the most common malignant brain tumor, leads to high recurrence rates and disabilities in patients. Pyroptosis is an inflammasomes‐induced programmed cell death in response to infection or chemotherapy. However, the role of pyroptosis in glioma has not yet been elucidated.MethodsRNA‐seq data and clinical information of 660 gliomas and 847 samples were downloaded from the TCGA and CGGA, respectively. Then, data of 104 normal brain tissues was retrieved from the GTEx for differential expression analysis. Twelve pairs of peritumoral tissue and glioma samples were used for validation. Gene alteration status of differentially expressed pyroptosis‐related regulators in gliomas was detected in cBioPortal algorithm. Consensus clustering was employed to classify gliomas based on differentially expressed pyroptosis‐related regulators. Subsequently, a PS‐signature was constructed using LASSO‐congressional analysis for clinical application. The immune infiltration of glioma microenvironment (TME) was explored using ESTIMATE, CIBERSORT, and the other immune signatures.ResultscBioPortal algorithm revealed alteration of these regulators was correlated to better prognosis of gliomas. Then, our study showed that pyroptosis‐related regulators can be used to sort out patients into two clusters with distinct prognostic outcome and immune status. Moreover, a PS‐signature for predicting the prognosis of glioma patients was developed based on the identified subtypes. The high PS‐score group showed more abundant inflammatory cell infiltration and stronger immune response, but with poorer prognosis of gliomas.ConclusionThe findings of this study provide a therapeutic basis for future research on pyroptosis and unravel the relationship between pyroptosis and glioma prognosis. The risk signature can be utilized as a prognostic biomarker for glioma.
Predicting survival in metastatic non‐small cell lung cancer patients with poor ECOG‐PS: A single‐arm prospective study
Authors: Cunha Mateus Trinconi , de Souza Borges Ana Paula , Carvalho Jardim Vinicius , Fujita André , de Castro Gilberto 
Published: September 2022

AbstractBackgroundPatients with advanced non‐small cell lung cancer (NSCLC) are a heterogeneous population with short lifespan. We aimed to develop methods to better differentiate patients whose survival was >90 days.MethodsWe evaluated 83 characteristics of 106 treatment‐naïve, stage IV NSCLC patients with Eastern Cooperative Oncology Group Performance Status (ECOG‐PS) >1. Automated machine learning was used to select a model and optimize hyperparameters. 100‐fold bootstrapping was performed for dimensionality reduction for a second (“lite”) model. Performance was measured by C‐statistic and accuracy metrics in an out‐of‐sample validation cohort. The “lite” model was validated on a second independent, prospective cohort (N = 42). Network analysis (NA) was performed to evaluate the differences in centrality and connectivity of features.ResultsThe selected method was ExtraTrees Classifier, with C‐statistic of 0.82 (p < 0.01) and accuracy of 0.81 (p = 0.01). The “lite” model had 16 variables and obtained C‐statistic of 0.84 (p < 0.01) and accuracy of 0.75 (p = 0.039) in the first cohort, and C‐statistic of 0.706 (p < 0.01) and accuracy of 0.714 (p < 0.01) in the second cohort. The networks of patients with lower survival were more interconnected. Features related to cachexia, inflammation, and quality of life had statistically different prestige scores in NA.ConclusionsMachine learning can assist in the prognostic evaluation of advanced NSCLC. The model generated with a reduced number of features showed high accessibility and reasonable metrics. Features related to quality of life, cachexia, and performance status had increased correlation and importance scores, suggesting that they play a role at later disease stages, in line with the biological rationale already described.
DNA damage response signaling: A common link between cancer and cardiovascular diseases
Authors: Nikfarjam Sepideh , Singh Krishna K. 
Published: September 2022

AbstractDNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to maintain a healthy genome. Dysregulation either in the form of down‐ or upregulation in the DDR pathways correlates with various pathophysiological states, including cancer and cardiovascular diseases (CVDs). Impaired DDR is studied as a signature mechanism for cancer; however, it also plays a role in ischemia‐reperfusion injury (IRI), inflammation, cardiovascular function, and aging, demonstrating a complex and intriguing relationship between cancer and pathophysiology of CVDs. Accordingly, there are increasing number of reports indicating higher incidences of CVDs in cancer patients. In the present review, we thoroughly discuss (1) different DDR pathways, (2) the functional cross talk among different DDR mechanisms, (3) the role of DDR in cancer, (4) the commonalities and differences of DDR between cancer and CVDs, (5) the role of DDR in pathophysiology of CVDs, (6) interventional strategies for targeting genomic instability in CVDs, and (7) future perspective.
Association between depression and anxiety status of breast cancer patients before adjuvant chemotherapy and chemotherapy‐induced adverse events
Authors: Lv Dan , Lan Bo , Zhang Li , Sun Xiaoying , Yang Min , Ma Fei 
Published: September 2022

AbstractPurposePatients with breast cancer are more likely to experience psychological distress than the general population. This study aimed to explore the relationship between depression and anxiety status measured before chemotherapy and adverse events during adjuvant chemotherapy in Chinese breast cancer patients.MethodsThis prospective study was conducted on 290 postoperative early‐stage breast cancer patients (response rate 96.7%) in China. Depression and anxiety status before adjuvant chemotherapy were assessed by the Hospital Anxiety and Depression Scale (HADS). Adverse events that occurred throughout the course of chemotherapy were graded and recorded according to Common Terminology Criteria for Adverse Events (CTCAE) 4.02.ResultsThe rates of depression and anxiety were 20.0% and 31.4%, respectively, at baseline. The incidence of grade two or higher myelosuppression induced by chemotherapy was correlated with depression before chemotherapy (p = 0.037). Multivariate analysis showed that the incidence of myelosuppression was significantly related to depression before chemotherapy (p = 0.032). There was no association between depression and anxiety status and other adverse events (p > 0.05).ConclusionsWe observed an association between depression status in breast cancer patients receiving adjuvant chemotherapy and chemotherapy‐induced myelosuppression. Monitoring the depression status of breast cancer patients before chemotherapy may help to optimize the management of adverse events.
New Jatrophane‐Type Diterpenoids from Euphorbia kansui as Potential MDR Reversal Agents
Authors: Zheng Qiong , Chen Ning‐Yu , Lou Si‐Qing , Liu Qian‐Qing , Luo Yi‐Tong , Liang Dong‐E , Zhan Zha‐Jun , Ma Lie‐Feng 
Published: September 2022

AbstractA serial jatrophane‐type diterpenoids, comprised with three undescribed compounds kanesulones C−E (1–3) and four known ones (4–7), were obtained from the roots of Euphorbia kansui. The structures of compounds 1–3 were elucidated by detailed interpretation of their spectroscopic data, especially 2D‐NMR and HR‐ESI‐MS, the absolute configuration of 1 was revealed by single crystal X‐ray diffraction. These isolates were assayed for their multidrug resistance reversing activities on human breast adenocarcinoma cell line MCF‐7/ADR. Compound 1 possessed potential as low toxic MDR modulator that could promote the efficacy of anticancer drug adriamycin ca. 85‐fold at 5 μM, as 12 times stronger than the positive drug verapamil.
Crystalline Metal‐Peptide Networks: Structures, Applications, and Future Outlook
Authors: Jeong Seoneun , Lee Kwonjung , Yoo Sung Hyun , Lee Hee‐Seung , Kwon Sunbum 
Published: September 2022

AbstractMetal‐peptide networks (MPNs), which are assembled from short peptides and metal ions, are considered one of the most fascinating metal‐organic coordinated architectures because of their unique and complicated structures. Although MPNs have considerable potential for development into versatile materials, they have not been developed for practical applications because of several underlying limitations, such as designability, stability, and modifiability. In this review, we summarise several important milestones in the development of crystalline MPNs and thoroughly analyse their structural features, such as peptide sequence designs, coordination geometries, cross‐linking types, and network topologies. In addition, potential applications such as gas adsorption, guest encapsulation, and chiral recognition are introduced. We believe that this review is a useful survey that can provide insights into the development of new MPNs with more sophisticated structures and novel functions.
Wernicke's encephalopathy: Is visual loss a red herring?
Authors: Kumar Sujit , Bolar Abdul Rawoof , Shetty Rohit , Govindappa Sharath Kumar Goddu , Pramod Manithody Narayan Bhat , Agadi Jagadish Basavaraj , Vishwanathan Lakshminarayanapuram Gopal , Adiga Chaitra Parameshwara 
Published: September 2022

AbstractPredominantly visual loss, is very rare in Wernicke's encephalopathy. A 22 year old lady, in her 28th week of gestation, presented with a confused mental state, bilateral papilloedema with retinal hemorrhages, ophthalmoparesis, and cerebellar signs. Her MRI brain was suggestive of Wernicke's encephalopathy and she recovered with intravenous thiamine
An unusual simultaneous occurrence of gastric carcinoma with lymphoid stroma, calcified leiomyoma and ectopic pancreas
Authors: Limaiem Faten , Omrani Sahir 
Published: September 2022

AbstractGastric carcinoma with lymphoid stroma is a rare variant of gastric carcinoma accounting for 1%–7% of gastric carcinomas. Its association with gastric leiomyoma and ectopic pancreas is extremely rare. We herein report an unusual simultaneous occurrence of gastric carcinoma with lymphoid stroma, calcified leiomyoma, and ectopic pancreas.
An Empirical Study on the Wear of Reciprocating Hydraulic Rod Seals Using 15 Different Oils
Authors: Feuchtmüller Oliver , Hörl Lothar , Bauer Frank 
Published: September 2022

AbstractHydraulic oils differ in their chemical composition and viscosity substantially. Their influence on the wear of rod seals is neither fully understood nor can be predicted precisely. The primary objective of this study was to evaluate the influence of various oils and their wetting properties on the wear of rod seals. In an empirical study, the wear of 30 commercially available polyurethane U‐cups was investigated with 15 different oils using a recently built test rig. The wear of rod seals increased with lower viscosity and higher polarity of the oil. Both oil properties are combined in a new parameter which helps to assess the lubricity of oil and the wear of rod seals.
Access to Enantiomerically PureP‐Stereogenic Primary Aminophosphine Sulfides under Reductive Conditions
Authors: Huber Tanja , Espinosa‐Jalapa Noel Angel , Bauer Jonathan O. 
Published: September 2022

AbstractStereochemically pure phosphines with phosphorus‐heteroatom bonds andP‐centered chirality are a promising class of functional building blocks for the design of chiral ligands and organocatalysts. A route to enantiomerically pure primary aminophosphine sulfides was opened through stereospecific reductive C−N bond cleavage of phosphorus(V) precursors by lithium in liquid ammonia. The chemoselectivity of the reaction as a function of reaction time, substrate pattern, and chiral auxiliary was investigated. In the presence of exclusively aliphatic groups bound to the phosphorus atom, all competing reductive side reactions are totally prevented. The absolute configurations of allP‐stereogenic compounds were determined by single‐crystal X‐ray diffraction analysis. Their use as synthetic building blocks was demonstrated. The lithium salt of (R)‐BINOL‐dithiophosphoric acid proved to be a useful stereochemical probe to determine the enantiomeric purity. Insights into the coordination mode of the lithium‐based chiral complex formed in solution was provided by NMR spectroscopy and DFT calculations.
Control of Allergic Rhinitis and Asthma Test: A systematic review of measurement properties and COSMIN analysis
Authors: Vieira Rafael José , Sousa‐Pinto Bernardo , Cardoso‐Fernandes António , Jácome Cristina , Portela Diana , Amaral Rita , Sá‐Sousa Ana , Pereira Ana Margarida , Bousquet Jean , Fonseca João Almeida 
Published: September 2022

AbstractThe Control of Allergic Rhinitis and Asthma Test (CARAT) is a patient‐reported outcome measurement (PROM) assessing the control of asthma and allergic rhinitis (AR) at a 4 week interval. This systematic review aimed to evaluate the measurement properties of CARAT. Following PRISMA and COSMIN guidelines, we searched five bibliographic databases and retrieved studies concerning the development, assessment of properties, validation, and/or cultural adaption of CARAT. The studies' methodological quality, the quality of measurement properties, and the overall quality of evidence were assessed. We performed meta‐analysis of CARAT measurement properties. We included 16 studies. Control of Allergic Rhinitis and Asthma Test displayed sufficient content validity and very good consistency (meta‐analytical Cronbach alpha = 0.83; 95% CI = 0.80–0.86;I2 = 62.6%). Control of allergic rhinitis and Asthma Test meta‐analytical intraclass correlation coefficient was 0.91 (95% CI = 0.64–0.98;I2 = 93.7%). It presented good construct validity, especially for correlations with Patient‐reported outcome measures assessing asthma (absolute Spearman correlation coefficients range = 0.67–0.73; moderate quality of evidence), and good responsiveness. Its minimal important difference is 3.5. Overall, CARAT has good internal consistency, reliability, construct validity and responsiveness, despite the heterogeneous quality of evidence. Control of Allergic Rhinitis and Asthma Test can be used to assess the control of asthma and AR. As first of its kind, this meta‐analysis of CARAT measurement properties sets a stronger level of evidence for asthma and/or AR control questionnaires.
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives
Authors: Alfonso Eddy E. , Troche Rogelio , Deng Zifang , Annamalai Thirunavukkarasu , Chapagain Prem , Tse‐Dinh Yuk‐Ching , Leng Fenfei 
Published: September 2022

AbstractBacterial DNA gyrase, an essential enzyme, is a validated target for discovering and developing new antibiotics. Here we screened a pool of polyphenols and discovered that digallic acid is a potent DNA gyrase inhibitor. We also found that several food additives based on gallate, such as dodecyl gallate, potently inhibit bacterial DNA gyrase. Interestingly, the IC50 of these gallate derivatives against DNA gyrase is correlated with the length of hydrocarbon chain connecting to the gallate. These new bacterial DNA gyrase inhibitors are ATP competitive inhibitors of DNA gyrase. Our results also show that digallic acid and certain gallate derivatives potently inhibit E. coli DNA topoisomerase IV. Several gallate derivatives have strong antimicrobial activities against Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus (MRSA). This study provides a solid foundation for the design and synthesis of gallate‐based DNA gyrase inhibitors that may be used to combat antibacterial resistance.
Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G‐Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity
Authors: Roy Soma , Muniyappa Kalappa , Bhattacharya Santanu 
Published: September 2022

AbstractAnthraquinone‐based compounds are well‐known as duplex DNA as well as G‐quadruplex DNA binders. Implications of various anthraquinone derivatives for specific recognition of G‐quadruplex DNA over duplex DNA is a ‘challenging’ research work that requires adequate experience with molecular design. To address this important issue, we designed and synthesized ten new 2,6‐disubstituted anthraquinone‐based derivatives with different functionalized piperazinyl side‐chains. Among these, particular compounds with certain distant groups have shown selective and significant binding affinities toward the c‐MYC and c‐KIT G‐quadruplex DNA over the duplex DNA, as noticed from various biophysical experiments. The structural difference of quadruplex and duplex DNA was utilized to probe these derivatives for the end‐stacking mode of binding with G‐quadruplex DNA. The ability of the ligands to halt DNA synthesis by stabilizing G‐quadruplex structures is one of the crucial points to further apply them for quadruplex‐mediated anti‐cancer therapeutics. Interestingly, these ligands trigger apoptosis to exhibit selective cytotoxicity toward cancer cells over normal cells. This was further evidenced by ligand‐induced cell cycle arrest as well as cellular apoptotic morphological changes. These blood‐compatible ligands provided detailed structure‐activity relationship approaches for the molecular design of anthraquinone‐based G‐quadruplex binders.
Porous Fe−N−C Aerogels Derived from Metal‐Organic Aerogels as Electrocatalysts for the Oxygen Reduction Reaction
Authors: Wang Yujun , Tu Rongxiu , Hou Chuantao , Wang Zonghua 
Published: September 2022

AbstractSynthesis of Fe−N−C electrocatalysts by pyrolysis of porous materials has been shown to be a promising pathway for the oxygen reduction reaction (ORR). Metal‐organic aerogels (MOAs) with unique micropores and mesopores should provide an excellent precursor for Fe−N−C electrocatalysts. This work reports a Fe−N−C aerogel synthesized by pyrolysis of MOA. The Fe−N−C aerogel shows excellent ORR performance in alkaline condition with an onset potential of 0.96 V (vs. RHE) and a limiting current density of 5.02 mA cm−2. The markedly enhanced ORR performance for Fe−N−C aerogel can be assigned to the synergistic catalytic effect between Fe−N catalytic sites and graphitized carbon and excellent mass transport due to the unique hierarchically porous architecture. In addition, satisfactory durability and methanol tolerance were obtained, demonstrating a promising material for ORR.
Electric Field‐Induced Self‐Assembly of Ultrafine Co/Ce Nanoparticles: Preparation of 3D Porous Composite Nanomaterials as Cathodes for Sodium‐Ion Batteries
Authors: Lin Shengnan , Zhang Tingan , Lv Guozhi , Wan Xingyuan 
Published: September 2022

AbstractIn this paper, Co3O4/Ce(OH)4/C and Co3O4/CeO2/C cathode materials for sodium‐ion batteries are prepared by electroconversion. The morphology, structure, and electrochemical properties are investigated by X‐ray diffraction, scanning electron microscopy, cyclic voltammetry, charge–discharge test, etc. The results show that Co3O4/Ce(OH)4/C and Co3O4/CeO2/C have the same crystal structure, the diffraction peaks of the samples are sharp, and the material crystallinity is high, and both are of nanospherical porous morphology. In electrochemical performance, the first discharge‐specific capacities of Co3O4/Ce(OH)4/C and Co3O4/CeO2/C are as high as 185.7 and 94.2 mAh g−1 at a rate of 0.1 A g−1. Moreover, the specific capacity of Co3O4/Ce(OH)4/C and Co3O4/CeO2/C increases after 1000 cycles at the 0.5 A g−1 rates, and the coulombic efficiency remains around 100%, showing excellent cycle performance.