bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Thermodynamic Properties of Ni2+, Co2+, Cu2+ Electrolyte Solutions by eMIVM-ET
Authors: Zheng Shijie , Xu Chenchen , Lu Yi , Tao Dongping 
Published: November 2022

Abstract
In this work, the electrolyte molecular interaction volume model (eMIVM) and the optimized model (eMIVM-ET) were used to fit the activity coefficients and osmotic coefficients of 47 heavy metal single electrolyte solutions containing Ni2+, Co2+ and Cu2+, respectively, and the activity coefficients and osmotic coefficients of 10 heavy metal two electrolyte solutions containing Ni2+, Co2+ and Cu2+ were predicted. The results show that the average deviation and average relative error of these two models are: the activity coefficients of eMIVM are 0.0548 and 7.22%, the osmotic coefficients are 0.0307 and 5.06%, the activity coefficients of eMIVM-ET are 0.0326 and 3.78%, and the osmotic coefficients are 0.0276and 4.73%, respectively; For the average deviation and relative error predicted by these two models, the activity coefficients of eMIVM are 0.2331 and 41.64% respectively, the osmotic coefficients are 0.2590 and 21.1% respectively, the activity coefficients of eMIVM-ET are 0.1340 and 24.88% respectively, and the osmotic coefficients are 0.1139 and 9.11% respectively. The prediction effect of eMIVM-ET is better than that of eMIVM, so eMIVM-ET can be used as an alternative thermodynamic prediction model.
Diversity and Composition Plants Species Along Elevational Gradient: Research Trends
Authors: Dani Ram Sharan , Divakar Pradeep Kumar , Baniya Chitra Bahadur 
Published: November 2022

Abstract
Studies on species richness pattern along elevation gradient is fascinatingly gaining consideration. We compiled data from 118 studies of elevational gradients between the years 2001- 2021 in a broad range of organisms throughout the world to estimate the designs of species richness and their determinants. The present study showed that more than half (57%) studies with unimodal hump-shaped richness pattern (maximum diversity at middle and lower at edges) followed by a monotonic decline (26%) in different taxa of plant. Nearly one-fifth studies (17.5%) followed either monotonic incline or reverse hump shaped or non-distinct patterns. Extensive studies in mountainous regions, more uniform model as a unimodal hump shape was present. In spite of latitudinal and elevation variation, both hemispheres showed similar patterns of species richness for all plant taxa. Some taxa showed bimodal and some others showed multi model patterns of elevation species richness patterns having peak diversity due to topographical and climatic factors. Upper and lower elevational ranges may provide extremities in temperature and rainfall for decreasing the species diversity. The mid domain effect may explain this species richness pattern. But this present study confirmed the presence of hump shaped species richness pattern due to extend of the midpoint elevation or elevation range considered for an individual species. Higher the midpoint value longer an elevation range that favours unimodal pattern.
Scaffold morphing and in-silico studies of potential BACE1 (β-secretase) inhibitors: A hope for newer dawn in anti-Alzheimer therapeutics
Authors: Bhatia Shiveena , Sharma Pratibha , Mujwar Somdutt , Singh Manjinder 
Published: November 2022

Abstract
Alzheimer’s disease (AD) is the prime cause for 65–80% of the dementia cases occurs due to the plaques and tangles deposition in the brain neurons leading to brain cell degeneration. β-secretase enzyme (BACE-1) is a key enzyme responsible for the deposition of extracellular plaques made of β-amyloid protein. Therefore, efforts are being applied to develop novel BACE-1 enzyme inhibitors to halt the plaque build-up. In our study, we analyzed some Elenbecestat analogues (a β-secretase inhibitor currently in clinical trials), designed by using structure-based drug designing and scaffold morphing approach at achieve superior therapeutic profile, followed by in silico studies like molecular docking, pharmacokinetics methodologies. The designed molecules showed good interactions with the catalytic dyad motifs (Asp228 and Asp32) of β-Secretase enzyme and having drug likeliness properties. Finally, the molecular dynamic studies were performed to analyses their thermodynamic stability and dynamic behavior of ligand with the active pocket of β-secretase.
The Relationship between Spirodiclofen Resistance and Wolbachia Endosymbiont in Tetranychus urticae Koch (Acari: Tetranychidae)
Authors: Bal Betül , Yorulmaz Sibel 
Published: November 2022

Abstract
Tetranychus urticae Koch (Acari: Tetranychidae) is an important pest that causes economic losses in many varieties of cultivated plants in the world. Wolbachia is an endosymbiont species found in many pests including mites. In pests, the mechanism underlying the interactions between insecticide resistance and endosymbiont is still not decisively understood.In this study, it was aimed to determine the relationship between spirodiclofen resistance in T. urticae and the presence of Wolbachia.Therefore, simultaneous selection of spirodiclofen was performed in both Wolbachia infected (GSS) and uninfected (GSSN) populations of T.urticae.Dry residue method was used to determine LC values in T. urticae. Bioassay experiments were applied to the larval stage of the mite. LC studies were established as 7 doses +1 control and 3 replications.Dead-alive counts were made at the end of the 7th day and resistance rates were determined. In the last selection of T. urticae with Wolbachia infection, 23-fold spirodiclofen resistance was determined, and in the last selection without Wolbachia infection, 103-fold resistance was determined.The presence of Wolbachia and frequency density were checked in both selection populations. The presence of Wolbachia was found to be quite low in all Wolbachia-uninfected selection populations compared to Wolbachia-infected populations.In addition, the relationship between spirodiclofen resistance and detoxification enzymes in mites was also investigated.As a result, it is thought that there may be a negative relationship between spirodiclofen resistance and Wolbachia endosymbiont in T. urticae, and that esterase enzyme may have an effect on the development of resistance within the scope of this relationship.
Femtosecond laser inscription of polarized-sensitive volume phase grating in nanoporous glass
Authors: Li Chunyu , Andreeva Olga V. , Zakoldaev Roman A. 
Published: November 2022

Abstract
With the growth of laser technologies in photonics, the volume phase elements fabrication in transparent material by ultrashort laser is widely attractive. Femtosecond laser writing (FLW) step was applied for the polarized-sensitive volume phase gratings (VPGs) inscription in the nanoporous silicate matrix (NPSM). The formed VPGs with thickness L = 54 ± 0.5 μm to 77 ± 0.5 μm, and shows the diffraction efficiency 8% and 14%，respectively. VPG in NPSM presents the ability to detect polarization. Different polarization angles correspond to different diffraction efficiency from 2% to 14%. Moreover, owing to the porous character of the NPSM plate, diffraction efficiency of impregnated VPG with distilled water and rhodamine 6G acetone solution were investigated. The achieved results in our experiment provides evidence to the possibility of VPG as a sensor application.
Methylated and mitochondria-targeted analogue of resveratrol with inhibition of tumor cell growth
Authors: Qi Ze-Ying , Wang Yi-Ru , Gao Chang , Chen Mei-Nuo , Li Min , Meng Ya-Li , Kang Yan-Fei , Wei Dong , Xin Zhen-Hui 
Published: November 2022

Abstract
The mitochondria are the energy and biosynthesis factory and the majority source of reactive oxygen species (ROS). The mitochondria play a vital role in carcinogenesis, so the mitochondria targeting drugs have been the focus of new drug discovery in cancer therapy. In this study, target mitochondrial stilbene compounds A1-A6 are synthesized by introducing lipophilic cationic triphenylphosphonium into the pharmacophore. Intriguingly, the strategy significantly improved the anticancer potential of parent resveratrol. Especially A4 ((E)-Triphenyl(4-(4-(3,4 dimethylstyryl)phenoxy)butyl)phosphoniumiodide) exerted the excellent anticancer activity in HeLa cells. The mechanism study showed that A4 could effectively decrease cyclin D1/cyclin E1 level to arrest the cell cycle in G0/G1, and target the mitochondria to induce apoptosis referring the cross-talk of the decreased ATPase activity, elevated ROS and increased cytosolic Ca2+ to inhibit tumor cell proliferation. Overall, this study is evidence that the target mitochondria drug discovery is an excellent strategy for exploiting the drug potential in cancer therapy.
IAMonSense: Multi-level Handwriting Classification using Spatio-temporal Information
Authors: Mustafid Ahmad , Younas Junaid , Lukowicz Paul , Ahmed Sheraz 
Published: November 2022

Abstract
Online handwriting classification has become an open research problem as it serves as a preliminary step for handwriting recognition systems and applications in several other fields. This paper aims to extend the current trends and knowledge with multiple contributions in handwriting classification using Spatio-temporal information. Firstly, it enriches the annotations of several publicly available online handwriting datasets, SenseThePen, IAM-onDB, IAMonDo, to be used for online handwriting classification and recognition tasks, i.e., stroke, sequence, and line level.The enriched annotations of the datasets extend their functionality for online handwriting classification at different levels for further research analysis. In addition to enrichment, it also unifies the annotation level across the datasets, which enables the research community to benchmark proposed methods for comparative analysis using multiple datasets. All the datasets with enriched annotations are made publicly available for the research community as part of the IAMonSense dataset.Moreover, this paper presents a comprehensive benchmark of these datasets using multiple deep neural networks such as traditional convolutional neural networks, graph neural networks, attention-based neural networks, and transformers. These benchmarks can be used later on for further development in the field of online handwriting classification.
Usefulness of Single Dose of Subcutaneous Modified Vaccinia Ankara for Human Monkeypox
Authors: Arbel Ronen , Wolff-Sagy Yael , Zucker Roy , Hammerman Ariel , Arieh Noa Gur , Markovits Hila , Abu-Ahmad Wiessam , Battat Erez , Ramot Noga , Carmeli Guy , Mark-Amir Avner , Wagner-Kolasko Gal , Duskin-Bitan Hadar , Yaron Shlomit , Peretz Alon , Lavie Gil , Netzer Doron 
Published: November 2022

Abstract
The recent global outbreak of the human monkeypox virus was declared a public health emergency by the WHO. Modified Vaccinia Ankara (MVA), provided in a two-dose regimen, is currently the only FDA-approved vaccine against monkeypox virus infection (MPXVi). Nevertheless, many have implemented a single-dose strategy to maximize vaccine supply because of a vaccine shortage. The emergency approval of MVA use for MPXVi was based only on efficacy data from non-human primates. Evidence for the real-life effectiveness of MVA in reducing MPXVi is still warranted. This observational, retrospective cohort study included all members of Clalit Health Services (CHS), eligible for the MVA vaccine on Jul. 31, 2022, when the CHS vaccination campaign was initiated. The rate of MPXVi in participants who received one dose of MVA was compared with that for participants who were not vaccinated. A Cox proportional-hazards regression model with time-dependent covariates was used to estimate the association between vaccination and MPXVi while adjusting for sociodemographic and clinical risk factors. A total of 2,092 subjects met vaccine eligibility criteria. Of those, 1,068 (51%) were vaccinated during the 105 days study period and completed at least 25 days of follow-up. During the study period, 5 infections were confirmed in the vaccinated and 16 infections were confirmed in the unvaccinated participants. The adjusted vaccine effectiveness was estimated at 87% (95% CI: 60%-95%). Our results suggest that a single dose of subcutaneous MVA is associated with a significantly lower risk for MPXVi in high-risk individuals and may contribute to the containment of the current outbreak.
An output of Kirchhoff Plate Equation with Bilinear Boundary controls
Authors: ELKABOUSS ABELLA , Bouhamed Abdelhak , Bouzahir Hassane 
Published: November 2022

Abstract
The current work focuses on the regional optimal control issue of the Kirchhoff Plate equation con- trols in a spatial domain Ω ⊂ R2, with constrained bilinear controls operating on the boundary of such an equation. It primarily concerns the tracking of a target state during the time interval[0,T], exclusively on a subregion of ω ⊂ Ω, minimizing a specified energy cost. Then we demonstrate that there is an optimal control, which is defined as a solution to an optimality system.
MSC: 93B05
Hydromagnetic Flow of Casson Fluid Over a Stretching Plane Through Porous Medium
Authors: Maurya Deepak K. , Deo Satya , Maurya Pankaj Kumar 
Published: November 2022

Abstract
The current analysis focuses on the MHD effects of a steady Casson fluid flowing overa stretching sheet in the porous medium. To examine the properties of non-Newtonian fluid, a mathematical model for Casson fluid is developed. Similarity transformationis used to convert higher order nonlinear governing partial differential equations (PDEs) into ordinary differential equations (ODEs). Analytical expressions of flow characteristics like velocity and skin friction coefficient are produced by applying the proper boundary conditions. Reports on specific instances of skin friction coefficient and fluid velocity (horizontal/transversal) are supplied. For various values of flow parameters, such as Casson parameter, suction velocity, conductivity, and permeability parameter, fluid flow characteristics, i.e. velocity profiles, and skin friction coefficient are sketched and analysed.
Improved path planning algorithm for mobile robots
Authors: Sun Liping , Duan Xiaoyu , Zhang Kai , Xu Pingan , Zheng Xiaoyao , Yu Qingying , Luo Yonglong 
Published: November 2022

Abstract
Path planning is an NP-hard problem in road network environments. Considering that the existing path planning algorithms mainly have the problems of low smoothness and low search efficiency in generating paths in large-scale complex environments, an improved rapidly exploring random tree (RRT) algorithm is proposed in this paper. First, the grid method is applied to model the road network environment, and the RRT algorithm based on adjacency expansion is proposed to search the initial path. Then, the strategies of identifying paths and eliminating redundant paths are adopted respectively to further optimize the selected paths. Experimental results show that, compared with other path planning algorithms, our algorithm can achieve faster convergence speed, shorter search path, and better smoothness in a complex map of the environment.
A new method for assessment of regional drought risk: information diffusion and interval mapping adjustment based on k-means cluster points
Authors: Xu Wentao , Tang Ming , Li Yanlei 
Published: November 2022

Abstract
Aiming at the defect that there is no ability for the conventional weighted comprehensive assessment method (WCA) to grade drought risk directly, a method based on k-means cluster points to realize the classification of drought risk is proposed in this paper. On the basis of calculating the drought risk value of cluster points, the inverse distance weight interpolation method (IDWI) and multidimensional normal diffusion method (MND) were used to quantify the drought risk value, and the discrimination between the risk value and grade was improved by interval mapping adjustment (IMA). In this paper, the drought risk of Anhui Province from 2000 to 2020 was calculated to verify the above method. The results show that: (1) The drought risk quantification method based on information redistribution of k-means cluster point can not only realize automatic risk classification, but also re-quantify the risk value of the assessment object in the same risk grade, which makes up for the defects that the conventional WCA cannot carry out grade division and the conventional clustering method cannot assign the risk value of the assessment object. (2) The result of information redistribution based on MND is closer to the actual drought situation and more reasonable than IDWI. (3) The dispersion effect of risk value obtained by information redistribution based on k-means cluster point can be improved by the IMA of drought risk. It improves the discrimination degree of risk value, so that the grades can be displayed more intuitively. The defect of the WCA is overcome by the new method proposed in this paper, the follow-up utilization space is widened, and the thinking of risk quantification in drought risk assessment is broadened.
Fatores associados à religiosidade/espiritualidade em pacientes no pré-operatório
Authors: Bastos Norma Lopes de Magalhães Velasco , Santos Maria da Conceição Quirino dos , Yarid Sérgio Donha 
Published: November 2022

Objetivo: Identificar fatores associados à religiosidade/espiritualidade de pacientes em período pré-operatório. Métodos: estudo transversal no qual participaram 60 pacientes de ambos os sexos em período pré-operatório. Resultados: foram avaliados 43 homens (71,67%) e 17 mulheres (28,33%) com média de idade de 41 anos (±19,00). Entre os pacientes com baixa espiritualidade prevaleceram os do sexo masculino (1,27 [IC95% 0,55–2,91]), com idade menos que 60 anos (7,47 [IC95% [1,09–51,09]), de cor parda (3,40 [IC95%0,51–22,62]), desempregados (4,8 [IC95% 1,54–14,90]) e católicos 1,09 [IC95% 0,46–2,62]). Pacientes com idade inferior a 40 anos apresentaram uma prevalência aproximadamente duas vezes maior para uma baixa religiosidade/espiritualidade (2,54 [IC95% (1,11 – 6,11) ]). Por outro lado, pacientes que autodeclararam alguma filiação religiosa, a prevalência de baixa religiosidade/espiritualidade foi muito menor (0,46 [IC95% 0,25 – 0,85]). Conclusão: o estudo evidenciou que a filiação religiosa se mostrou como fator de proteção para baixa religiosidade/espiritualidade em pacientes no pré-operatório.
Palavras-Chaves: Espiritualidade; Religião e Ciência; período pré-operatório; avaliação da pesquisa em saúde; centro cirúrgico hospitalar.
Assessment of Clinical Information Quality in Digital Health Technologies: International eDelphi Study
Authors: Fadahunsi Kayode Philip , Wark Petra A , Mastellos Nikolaos , Neves Ana Luisa , Gallagher Joseph , Majeed Azeem , Webster Andrew , Smith Anthony , Choo-Kang Brian , Leon Catherine , Edwards Christopher , O'Shea Conor , Heitz Elizabeth , Kayode Olamide Valentine , Nash Makeba , Kowalski Martin , Jiwani Mateen , O'Callaghan Michael Edmund , Zary Nabil , Henderson Nicola , Chavannes Niels H , Čivljak Rok , Olubiyi Olubunmi Abiola , Mahapatra Piyush , Panday Rishi Nannan , Oriji Sunday O , Fox Tatiana Erlikh , Faint Victoria , Car Josip 
Published: November 2022

Background
Digital health technologies (DHTs), such as electronic health records and prescribing systems, are transforming health care delivery around the world. The quality of information in DHTs is key to the quality and safety of care. We developed a novel clinical information quality (CLIQ) framework to assess the quality of clinical information in DHTs.

Objective
This study explored clinicians’ perspectives on the relevance, definition, and assessment of information quality dimensions in the CLIQ framework.

Methods
We used a systematic and iterative eDelphi approach to engage clinicians who had information governance roles or personal interest in information governance; the clinicians were recruited through purposive and snowball sampling techniques. Data were collected using semistructured online questionnaires until consensus was reached on the information quality dimensions in the CLIQ framework. Responses on the relevance of the dimensions were summarized to inform decisions on retention of the dimensions according to prespecified rules. Thematic analysis of the free-text responses was used to revise definitions and the assessment of dimensions.

Results
Thirty-five clinicians from 10 countries participated in the study, which was concluded after the second round. Consensus was reached on all dimensions and categories in the CLIQ framework: informativeness (accuracy, completeness, interpretability, plausibility, provenance, and relevance), availability (accessibility, portability, security, and timeliness), and usability (conformance, consistency, and maintainability). A new dimension, searchability, was introduced in the availability category to account for the ease of finding needed information in the DHTs. Certain dimensions were renamed, and some definitions were rephrased to improve clarity.

Conclusions
The CLIQ framework reached a high expert consensus and clarity of language relating to the information quality dimensions. The framework can be used by health care managers and institutions as a pragmatic tool for identifying and forestalling information quality problems that could compromise patient safety and quality of care.

International Registered Report Identifier (IRRID)
RR2-10.1136/bmjopen-2021-057430
economía mexicana en la trampa de la continuidad neoliberal. Política económica y sector externo
Authors: Rosas Barrera Salvador 
Published: November 2022

El autor de la obra cuestiona la manera en que el actual gobierno mexicano (2022) ha manejado las políticas fiscal y monetaria, porque profundizan la fragilidad de la economía nacional, refuerzan la creciente dependencia respecto del comportamiento del capital internacional y toda una infraestructura construida para favorecerlo. Considera que tales medidas obstaculizan cualquier intento de cambio de rumbo para impulsar el crecimiento económico soberano en favor de un aparato productivo subutilizado, el empleo y el mejoramiento de las condiciones de vida de la población, así como de la posición comercial de México en el mundo.
Robust cellular immune responses following two doses of BNT162b2 mRNA vaccine against SARS-CoV-2 in type 2 diabetic subjects: A longitudinal study in Bangladesh
Authors: Habib Shahriar , Akhter Tahmina , Nessa Afzalun 
Published: November 2022

Background: Diabetes, one of the most common comorbidities of
COVID-19, is prioritized for SARS-CoV-2 vaccination. To evaluate the
T-cell mediated immune responses, this study assessed and compared IFN-γ
and IL-2 secreting PBMCs against the SARS-CoV-2 BNT162b2 mRNA vaccine in
individuals with type 2 diabetes mellitus. Methods: In this
longitudinal study, 19 known cases of type 2 diabetes and 16 healthy
controls were included through purposive sampling and were regularly
sampled before 1 dose, 4 weeks after
1 dose and 2-4 weeks after 2dose
of vaccination. Ex-vivo ELISpot assays for IFN-γ and IL-2 were done
using isolated PBMCs. HbA1c status was determined by an automated
analyzer before 1 dose and SARS-CoV-2 spike-specific
IgG antibody were assessed by CLIA 4 weeks after
1dose. A p -value <0.05 was
considered significant. Results: All participants were
seroconverted after 1 dose and showed a robust rise
of IFN-γ and IL-2 secreting PBMCs counts in type 2 diabetic participants
irrespective of hypertension, gender and age after two doses of
vaccination. However, IFN-γ secreting PBMCs counts were significantly
lower in type 2 diabetic group than healthy control group after
1 dose. Substantial negative correlations of HbA1c
(%) to IFN-γ secreting PBMCs counts after 2 dose
were also found in this study. Conclusion: Although type 2
diabetic participants had a lower response initially, BNT162b2 mRNA
vaccine overall induces a robust T-cell mediated immune response.