bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly ordered deuterated ice XIV
Authors: Hauschild Elisabet , Tonauer Christina , Eisendle Silvia , Landete Violeta Fuentes , Yamashita Keishiro , Hoffmann Lars , Böhmer Roland , Loerting Thomas 
Published: August 2022

Abstract
Highly ordered D2O ice XIV is identified as a possible new candidate phase for ice XX (PNP-ice XX) on the basis of calorimetry, dielectric relaxation spectroscopy, powder X-ray diffraction, and volumetric measurements. Previous work yielded weakly ordered deuterated ice XIV featuring less than 20% of the maximum order defined in terms of Pauling's configurational entropy. Here, we introduce a preparation protocol that allows for highly ordered ice XIV, with a degree of order between 40% and 65%. This protocol involves 110 minutes of annealing of doped ice XII at 94 K and 0.81 GPa, followed by recovery to ambient pressure and storage in liquid nitrogen. The use of both DCl-doping to produce ionic and Bjerrum defects as well as the addition of 1% H2O to produce dynamic H-defects in the bath of D-atoms are key for accelerating the ordering process. At 94 K the dielectric relaxation of highly ordered ice XIV is about ten times slower than that of weakly ordered ice XIV. By contrast to weakly ordered ice XIV, the dielectric relaxation times of highly ordered D2O ice XIV feature a clear kink near the transition to ice XII at 102 K. Furthermore, the volume changes by about 0.6% at the transition of ice XII to ice XIV, owing to the impact of H-ordering on the O-atom network. Powder X-ray diffraction on highly ordered D2O ice XIV reveals several Bragg peaks splittings that are not resolved in weakly ordered ice XIV. These superstructure reflections indicate the presence of a new crystallographic phase and call for powder neutron-diffraction studies to fully elucidate the crystal structure of highly ordered ice XIV.
Interface Engineering for Substantial Performance Enhancement in Epitaxial All Perovskite Oxide Capacitor
Authors: Kim Youngsung , Bang Jeongil , Lee Jaeho , Do Eun Cheol , Kim Hyungjun , Na Byunghoon , Kim Haeryong , Park Bo-Eun , lee Jooho , Kim Che-Heung , Jang Ho Won 
Published: August 2022

Abstract
Capacitors based on ABO3-type perovskite oxides show considerable promise for overcoming the limitations of nanoscale integration for dynamic random access memory (DRAM) devices. Among thermodynamically stable perovskite oxides, titanates (ATiO3) exhibit high dielectric permittivity in metal–insulator–metal (MIM) configurations. However, their ultimate properties remain under scrutiny for mitigating the large leakage current caused by their narrow bandgap (3 eV). Herein, substantially enhanced dielectric properties of an epitaxial SrRuO3/Ba0.5Sr0.5TiO3/SrRuO3 MIM capacitor with a thin dielectric layer (10 nm) are reported. The dielectric/electrode heterointerface was engineered to realize a capacitor with low leakage current and high dielectric permittivity. A pit-free and stoichiometric SrRuO3 bottom electrode with atomically smooth surface was exploited for suppressing defect formation at the heterointerface. The critical roles of oxygen vacancies and substituted transition-metal atoms in determining the leakage current were accessed and a strategy for reducing the leakage current via interface engineering was established. Consequently, a dielectric permittivity of 861 and leakage current density of 5.15 × 10− 6 A/cm2 at 1 V were obtained with the thinnest dielectric layer ever reported. Our work paves the way for the development of perovskite-oxide-based capacitors in next-generation DRAM memories.
Influence of Powder Production Process and Properties on Material Properties of Ti 6Al 4V Manufactured by L-PBF
Authors: Meier Benjamin , Warchomicka Fernando , Petrusa Jelena , Angerer Paul , Wosik Jaroslaw , Kaindl Reinhard , Petrovic Vojislav , Waldhauser Wolfgang , Sommitsch Christof 
Published: August 2022

Abstract
Besides process parameters, powder properties such as grain size, morphology and chemical composition have the highest impact on material properties of parts produced by powder based additive manufacturing. These properties are strongly influenced by the production process of the powder and its feedstock. In scope of this work this influence of three different powder producers of Ti6Al4V, on density, chemical composition, and mechanical properties of build samples are investigated. Further the effects of the varying atomization process on morphology, particle size distribution, chemical composition and oxide layers are studied. Particle size distribution and flowability seem to have minor influence on the production process while density depends highly on the surface topology, sphericity and nature of the oxide layer, which affect energy intake. Tensile properties are highly influenced by chemical composition, mainly dissolved oxygen and polluting satellites, while notched bar impact strength is additionally influenced by the oxide layer and suspected TiO 2 precipitations caused by it.
Identification, Evolution, and Expression Analysis of OsBSK Gene Family in Oryza sativa Japonica
Authors: Zhang Shuo , Hu Xuewei , Dong Jiejing , Du Mengxiang , Song Juqi , Xu Shangyuan , Zhao Changjiang 
Published: August 2022

Abstract

Background
As an essential component of the BR (brassinosteroid) signaling pathway, BSK (BR-signalling kinases) plays a vital role in plant growth, development, and stress regulation. There have been sporadic reports on the functions of members of this family in monocotyledonous model plant rice, but few reports have been reported on the phylogenetic analysis and gene expression profiling of the family genes.
Results
In this study, a total of 6 OsBSK members were identified at the genomic level by bioinformatics methods, distributed on four rice chromosomes. Through the evolution analysis of 73 BSK proteins from 22 species, it was found that BSKs originated from higher plants, were highly conserved, and could be divided into six subgroups. Among them, OsBSKs belong to four subgroups or two significant groups. OsBSK family gene promoters contain a large number of light, abscisic acid (ABA), and methyl jasmonate (MeJA) response-related elements. At the same time, the qRT-PCR test also showed that the genes of this family of rice were involved in response to a variety of hormones, biotic and abiotic stress treatments, and expression patterns of the family gene can be roughly divided into two categories, which were similar to the tissue expression patterns of genes in different growth stages. OsBSK1, OsBSK3, and OsBSK5 were mostly up-regulated. OsBSK4, OsBSK6, and OsBSK2 were mostly down-regulated or had little change in expression.
Conclusions
This study revealed the origin and evolution of the BSK family and the farm-out of BSKs in rice growth, development, and stress response. It provided the theoretical reference for in-depth analysis of BR hormone and signal transduction pathway, and molecular breeding design for resistance.
Foreshock properties illuminate nucleation processes of slow and fast laboratory earthquakes
Authors: Bolton David , Marone Chris , Saffer Demian , Trugman Daniel 
Published: August 2022

Abstract
Understanding the connection between seismic activity and the earthquake nucleation process is a fundamental goal in earthquake seismology with important implications for earthquake early warning systems and forecasting. We use high-resolution acoustic emission (AE) waveform measurements from laboratory stick-slip experiments that span a spectrum of slow to fast slip rates to probe laboratory foreshocks and nucleation. We measure the waveform similarity of AE templates and use differential travel-times to track their relative locations. Fast laboratory earthquakes are preceded by a late, rapid increase in waveform similarity prior to failure, whereas slow slip events show a modest increase in waveform similarity before failure. Differential travel-time and waveform similarity measurements reveal a spatiotemporal coalescence of foreshocks prior to failure. Our work suggests that laboratory foreshocks evolve systematically prior to stick-slip failure and are a byproduct of a slow nucleation process driven by pre-seismic fault slip.
The circulating phageome reflects bacterial infections
Authors: Haddock Naomi , Barkal Layla , Ram-Mohan Nikhil , Kaber Gernot , Chiu Charles , Bhatt Ami , Yang Samuel , bollyky Paul 
Published: August 2022

Abstract
Bacteriophage, viruses that infect bacteria, are abundant in the human body but the relationship between the phageome and bacterial population dynamics is unclear. Because bacteriophage are often highly specific to bacterial host strains and species, we asked whether bacteriophage present in cell-free DNA (cfDNA) reflect bacterial infections in sepsis and other infections. To address this, we generate a computational pipeline for identifying bacteriophage sequences in cfDNA. In three large, independent cohorts of infected patients and asymptomatic controls, we demonstrate that all individuals have a circulating phageome. Moreover, infection associates with overrepresentation of pathogen-specific phage, allowing for identification of bacterial pathogens. We further show that phage can identify pathovariant Escherichia coli infections and distinguish between closely-related pathogenic bacteria such as Staphylococcus aureus and frequent contaminants such as coagulase-negative Staphylococcus. Phage DNA may have utility in identifying bacterial pathogens in infection and studying bacterial dynamics.
Indoor Household Water Consumption Data Generation Model by Use of Probability Distributions
Authors: Wang Dong , Liu Zhen , Yuan Jia , Li Lei , Liu Xin 
Published: August 2022

Abstract

An indoor household water consumption data generation model is proposed by use of probability distributions of six different end-uses (shower, bath，toilet, tap, washing mashing, dishwasher) on a temporal scale of one hour. Based on the probability distributions of six residential indoor end-use events in terms of household size, daily event frequency, event occurrence time and water consumption volume recently developed, the precise daily water consumption in hour resolution can be analytically deduced without original dataset collected from water resource management department. Then, the quantitative relationships between household water usage and the influence factors affecting the residential water consumption: air temperature and water-saving consciousness are derived to modify the above data in order to make the results more consistent with the actual situation. Considering that the daily air temperature is closely related to the shower, bath, washing machine frequency, setting the 25℃ as the temperature threshold. At the meantime, residents’ awareness of water-saving has a significant effect on water resource conservation that the water flows from tap can be recycled utilized for flushing the toilet. Simulation results show that the data generated from the model have a strong consistency with real data demonstrating the effectiveness and merit of the proposed method.
Determining deviation of the growth pattern of preterm infants and its causes according to Fenton growth chart: A cross-sectional study
Authors: Jamali Zahra , Dehghani Fatemeh , Sabzevari Fatemeh , Parisi Zahra Daei , Bijari Bahareh Bahman 
Published: August 2022

Abstract
Background
This study performed to determine the frequency of postnatal growth retardation and its causes in preterm infants from hospitalization to 6 months after birth.
Methods
During one year (2020–2021), 255 preterm singleton infants weighing less than 2500g and gestational age less than 37 weeks of menstruation were born in Afzalipour medical education and health center in Kerman, Iran, were included in the study after receiving parental information. To evaluate the growth pattern of infants, anthropometric characteristics of infants including; birth weight, height, and head circumference at birth and ages 7, 14, 28 days, and then monthly to 6 months were recorded and compared with the Fenton growth chart. In addition, type of feeding, length of hospital stay, duration of invasive mechanical ventilation and receiving oxygen, length of receiving TPN, and causes and complications during hospitalization were recorded in a special questionnaire.
Results
The mean Z-score weight at birth and discharge at one, three, and six months were − 0.34, -1.19, -0. 85, -0.94, and − 1.79 respectively. The mean Z-score height at birth, time of discharge, one, three, and six months were 0.74, 0.20, -0.07, -0.79, and − 2.5 respectively. Also, the mean Z-score head circumference at birth, the time of discharge, one, and three months were 0.41, -0.19, -0.53, and − 1.17 respectively. Deviation from the Fenton GROWTH CHART (PGF), at the time of discharge, detected in 109 infants (42.7%), at one month 79 (31%), at three months 82 (32.2%) and at six months of age 134 (52.5%).
Conclusion
hospitalized Preterm babies have a slower growth rate than a healthy preterm infant due to complications such as sepsis, surgical problems, feeding intolerance, etx. Therefore, the interpretation of their longitudinal growth data should be done with caution. Improving the quality of care in NICU wards, more attention to optimizing their nutrients, short-term use of parenteral nutrition, and increasing the rate of enteral feeding reduces the incidence of PGF.
Exploration of a superior water-resistant protein coating with inherent functionality inspired by scallop byssus
Authors: Wang Lulu , Xue Bo , Xu Pingping , Liu Weizhi 
Published: August 2022

Abstract
Multifunctional coatings with superior water-resistance are urgently needed for clinical translational research, but few strategies can fabricate such protein coatings in a convenient way, especially under physiological conditions. Herein, we report a protein coating derived from scallop byssal protein 9 (Sbp9∆) with a superior water-resistant capacity and attractive traits, which was obtained by adapting a previously unexplored coating formation mechanism. We find that the reticulate coatings can be rapidly self-assembled in situ within 30 min after initiation with Ca2+. The self-assembly is mainly driven by direct interactions composed of hydrogen and coordinate bonds. Notably, the protein coatings exhibit superior water-resistant stability, mechanical performance similar to that of biological soft tissues, and well biocompatibility. Furthermore, proof-of-concept applications show that Sbp9∆ coatings can be directly used as cell-culture matrices to promote cell adhesion and spreading, as well as accelerate skin wound healing caused by photoaging and diabetes.
Effect of Multi-walled carbon nanotubes on the performance evaluation of Nickel-based super-alloy–Udimet 720 machined using WEDM process
Authors: Chaudhari Rakesh , Ayesta Izaro , Doshi Mikesh , Khanna Sakshum , Patel Vivek K. , Vora Jay , De Lacalle Luis Norberto López 
Published: August 2022

Abstract
The diverse capabilities of nickel-based super-alloy (Udimet 720), like robust mechanical strength, ductility, resistance to excessive temperature deformation, and advanced corrosion and oxidation resistance, make it suitable for use in multiple applications. These super-alloys are identified as extremely difficult materials for machining to meet feature and manufacturing requirements. In the present work, we demonstrated the machining of Udimet 720 by employing the wire-electrical discharge machining (WEDM) technique. Pulse-on-time (Ton), Pulse-off-time (Toff), current, and MWCNT amount were preferred as input variables. The effect of selected design variables was studied on material removal rate (MRR), surface roughness (SR), and recast layer thickness (RLT). Box Behnken design was utilized to design an experimental matrix. For statistical analysis, analysis of variance (ANOVA) was employed. From ANOVA, the current had the highest contributor with 35.85% to affect MRR, while MWCNT amount was found to be the highest contributor for deciding the values of both SR and RLT with contributions of 42.66% and 40.07%, respectively. The addition of MWCNT at 1 g/L has substantially improved MRR from 0.8546 g/min to 1.2199 g/min, SR reduced from 5.88 µm to 2.98 µm, and reduction in RLT from 17.8 µm to 11.61 µm. The passing vehicle search (PVS) algorithm was implemented, and the results of single-objective optimization presented the largest MRR of 1.8883 g/min, least SR of 1.89 µm, and least RLT of 9.70 µm. Additionally, a set of non-dominated solutions was obtained through Pareto optimal fronts. A small acceptable deviation was detected among the actual and forecasted results from PVS algorithm. It clearly reveals the acceptance of the PVS technique in the present study for Udimet 720. Lastly, the significance of MWCNT amount on surface textures was revealed by employing scanning electron microscopy (SEM).
Hyperactive NK cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia
Authors: Sugimoto Emi , Hayashi Yasutakka , Iida Kohei , Asada Shuhei , Fukushima Tsuyoshi , Tamura Moe , Kawabata Kimihito , Kawase Tatsuya , Saito Takeshi , Yoshida Taku , Yamazaki Satoshi , Kaito Yuta , Imai Yoich , Fukuyama Tomofusa , Tanaka Yosuke , Enomoto Yutaka , Kitamura Toshio , Goyama Susumu 
Published: August 2022

Abstract
Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML was retarded in Rag2-/- mice despite the lack of B and T lymphocytes, even compared to the immunologically normal C57BL/6 mice. Furthermore, an orally active p53-activating drug showed stronger antileukemia effect on AML in Rag2-/- mice than C57BL/6 mice. Intriguingly, NK cells in Rag2-/- mice were increased in number, highly expressed activation markers, and showed increased cytotoxicity to leukemia cells in a coculture assay. B2m depletion that triggers missing-self recognition of NK cells impaired the growth of AML cells in vivo. In contrast, NK cell depletion accelerated AML progression in Rag2-/- mice. We also found that immunogenicity of AML kept changing during tumor evolution, showing a trend that AMLs with strong leukemogenicity were susceptible to NK cell-mediated tumor suppression in Rag2-/- mice. Thus, our study highlighted the critical role of NK cells in suppressing the development of certain subtypes of AML, and demonstrated that Rag2-/- mice, which are generally considered as “immunodeficient” due to the lack of functional lymphocytes, in fact have hyperactive NK cells with the enhanced antileukemia immunity.
Circulating miR-182-5p for protection of endothelial function from ADMA–induced injury inelderly coronary artery
Authors: Zhang Jiao , Yu Hong , Wang Xiaona , Si Quanjin , Zhao Yangong , Duan Yuanyuan , Ye Ping 
Published: August 2022

Abstract
Background
To investigate the correlation between the expression level of miR-182-5p and endothelial function in elderly individuals.
Methods
One thousand and fifty-eight patients > 60 years old living in the Pingguoyuan area in China were enrolled consecutively and were divided into four groups according to the results of reactive hyperemia index (RHI), and asymmetric dimethylarginine (ADMA). Gruop1 (n = 294):RHI ≥ 1.67 and ADMA ≤ 0.7umol/l (named the normal endotheltial function group); Group2 (n = 244):RHI ≥ 1.67 and ADMA > 0.7umol/l; Group3 (n = 242): RHI < 1.67 and ADMA ≤ 0.7umol/l; Group4 (n = 278):RHI < 1.67 and ADMA > 0.7umol/l(named the endotheltial dysfunction group). The association between miR-182-5p level, RHI and ADMA were analyzed using univariate correlation analysis and multiple regression analysis.
Results
RT-PCR results showed that the expression level of miR-182-5p in the endothelial dysfunction group was significantly lower than that in the normal endothelial function group. In addition,we found that the expression level of plasma miR-182-5p was negatively correlated with plasma ADMA.
Conclusion
MiR-182-5p had a protective effect on endothelial function and may be a potential therapeutic target for atherosclerosis in elderly individuals.
STK33 Promotes the Proliferation and Metastasis of Human Esophageal Squamous Cell Carcinoma via Inflammation Related Pathway
Authors: Wang Hongmei , Huang Lingyan , Li Liping , Ma Tao , Jiang Haifeng , Wang Ruixiao , Chen Xiaozhen , Xu Ke , Chen Chen , Han Zhe 
Published: August 2022

Abstract
The serine/threonine kinase STK33 has been implicated in cancer cell proliferation. Abnormal expression of STK33 is closely related to malignant tumors of many cancers. Here, we provide evidence of a critical role for STK33 in the pathogenesis and metastatic progression of esophageal squamous cell carcinoma (ESCC). In human ESCC specimens, STK33 was overexpressed and associated with poor prognosis. Silencing STK33 expression inhibited ESCC proliferation, migration, invasion, and tumor growth. Furthermore, STK33 was also involved in angiogenesis, TGFB, and inflammatory response in ESCC. Mechanistic investigations showed that STK33 regulated ESCC through multiple complex pathways. In showing that dysregulated STK33 signaling promotes ESCC growth and progression, our results suggest STK33 as a candidate therapeutic target to improve ESCC treatment.
Personalized Sampling Graph Collection with Local Differential Privacy for Link Prediction
Authors: Jiang Linyu , Yan Yukun , Tian Zhihong , Xiong Zuobin , Han Qilong 
Published: August 2022

Abstract
Link prediction (LP) is an attractive research problem on social network data. Yet, the link information may be leaked by the untrusted collector. As countermeasures, there are a few methods specially designed for link prediction under local differential privacy (LDP), which allow the third-party data collector collects user data for link prediction while protecting user connection privacy. In this paper, we propose a Community-based graph collection with Personalized sampling Randomized Response (CPRR) which is a novel graph collection algorithm with LDP and reaches decent trade-off between sensitive link protection and link prediction performance. The proposed mechanism adopts a personalized sampling technique for each connection of a user and then utlizes the randomized response mechanism on the sampled subset. Based on the personalized sampling technique, we can reduce the injected noise in LDP. Meanwhile, considering the different edge distributions of the different regions on the original graph, we propose a community-based sampling strategy. Then, we prove that the proposed CPRR satisfies LDP. %We compare the performance of CPRR and other privacy-preserving graph collection methods under LDP in terms of link prediction accuracy. Through extensive experiments on several real-life graph datasets, we demonstrate that CPRR can achieve better results in balancing privacy protection and link prediction performance than the state-of-art baselines