bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post COVID‐19 organizing pneumonia treated with mycophenolate mofetil
Authors: Tan Hui Xin , Wong Chee Kin , Yik Weng Fai , Lam Yoke Fong , Lachmanan Kumaresh Raj 
Published: September 2022

AbstractOrganizing pneumonia (OP) promptly responds to corticosteroids. However, a minority of patients demonstrate corticosteroid resistance or relapse on corticosteroid tapering. We describe post COVID‐19 OP patients with clinically inadequate response to corticosteroids but that improved after the addition of Mycophenolate Mofetil (MMF). Case 1: A gentleman was diagnosed with post COVID‐19 OP but had suboptimal clinico‐physiologic‐radiologic response and steroid toxicity during outpatient reviews. MMF was initiated resulting in marked clinical response and quick weaning from corticosteroids. Case 2: A gentleman with post COVID‐19 OP relapsed during tapering of steroids. Clarithromycin and MMF were added to his regimen, which improved his clinico‐physiologic parameters and allowed corticosteroid tapering. Unfortunately, he developed MMF‐related colitis needing therapy cessation. Currently, no studies have reported on MMF utilization in difficult post COVID‐19 OP patients. Nevertheless, we believe, similar as in non‐COVID OPs, MMF or other immunomodulators, potentially have a role in treating difficult or steroid‐resistant OPs.
Security in5Gand beyond recent advances and future challenges
Authors: Salahdine Fatima , Han Tao , Zhang Ning 
Published: September 2022

Abstract5G, 6G, and beyond (xG) technologies aim at delivering emerging services with new requirements and challenges, enabling full and hyper mobile connectivity over the world. These beyond 5G networks are expected to ensure better quality of service, very high data rate, improved network security, high capacity, low latency, and low cost. In order to meet these objectives, a number of key enabler technologies have been proposed including massive multiple input multiple output, small cells, mobile edge computing, software defined network, network function virtualization, heterogeneous networks, network slicing, cloud radio access network, ultra‐dense network, energy efficiency, and spectrum sharing. Although, the potential interest of these technologies in the network, they opened the door to many security concerns and challenges making the network security one of the primary concerns of the future wireless communication networks. In this article, we investigated the recent advancements on the xG security issues resulted by each key enabler technologies. We analyzed how to secure the network while meeting the emerging promising services, users' demands, and service requirements. We also discussed how the security issues raised by these emerging technologies can be mitigated for efficient and secure communication.
Evaluation of environmental assessment tools for settings for individuals living with dementia
Authors: Calkins Margaret P. , Kaup Migette L. , Abushousheh Addie M. 
Published: September 2022

AbstractIntroductionThe overarching goal of research on physical settings for individuals living with dementia is to identify associations between designed features within the built environment and outcomes of interest. Over the past three decades numerous environmental assessment tools have been developed in several countries, responding to a changing set of care industry values that increasingly prioritize a holistic, quality‐of‐life–driven person‐centered care (PCC) model over a biomedical approach to long‐term care (LTC) provision. This article reviews the diversity, constructs, strengths, and limitations of existing environmental assessment tools and identifies gaps for future tool development.MethodsA systematic literature search was conducted using four databases (Medline, CINAHL, PsycInfo, and Avery Index) and terms related to health‐care environments and assessment tools.ResultsA total of 13 environmental assessment tools for people living with dementia within shared residential settings were identified. Evaluation of the environmental assessment tools includes a synthesis of published data for each tool's reliability, validity, ease of use, interpretability, strengths and weaknesses, as well as a comparison of various tool characteristics including date of development, country of origin, applicable care setting(s), number and variety of measures and underlying constructs, format, and descriptive versus evaluative content.DiscussionWhile the shift to person‐centered values encompasses all aspects of care and care settings, the majority of person‐centered definitions exclude the important role of the designed, physical environment. However, this review of environmental assessment tools clearly demonstrates that newer tools are embracing the full array of PCC values. In the United States, this is shown in the shift from tools designed to assess segregated dementia care settings to tools that integrate the needs and preferences both of individuals living with and without dementia. Next‐generation tools need to specifically address the household model of design.Highlights
The overarching goal of research on physical settings for individuals living with dementia is to identify associations between designed features within the built environment and outcomes of interest.
A systematic literature search identified a total of 13 environmental assessment tools for people living with dementia within shared residential settings; these tools were then described and evaluated based on reliability, validity, ease of use, interpretability, strengths, and weaknesses.
This review of environmental assessment tools clearly demonstrates that newer tools are embracing the full array of person‐centered care values.
Lesion‐to‐anal‐verge distance in rectosigmoid endometriosis on transvaginal sonography vs magnetic resonance imaging: prospective study
Authors: Aas‐Eng M. K. , Young V. S. , Dormagen J. B. , Pripp A. H. , Hudelist G. , Lieng M. 
Published: September 2022

ABSTRACTObjectivesTo compare transvaginal sonography (TVS) and magnetic resonance imaging (MRI) with intraoperative measurement (IOM) using a rectal probe in the estimation of the location of rectosigmoid endometriotic lesions, i.e. lesion‐to‐anal‐verge distance (LAVD), and to compare two different MRI techniques for measuring LAVD.MethodsThis was a prospective single‐center observational study that included women undergoing surgery for symptomatic rectosigmoid endometriosis by discoid (DR) or segmental (SR) resection from December 2018 to December 2019. TVS and MRI were performed presurgically for each participant to evaluate LAVD, and the measurements on imaging were compared with IOM using a rectal probe. Clinically acceptable difference and limits of agreement (LoA) between TVS and MRI compared with IOM were set at ± 20 mm. Two different measuring methods for MRI, MRICenter and MRIDirect, were proposed and evaluated, as there is currently no guideline to describe deep endometriosis on MRI. Bland–Altman plots and LoA were used to assess agreement of TVS and both MRI methods with IOM. Systematic and proportional biases were assessed using paired t‐test and Bland–Altman plots.ResultsSeventy‐five women were eligible for inclusion. Twenty‐eight women were excluded, leaving 47 women for the analysis. Twenty‐three DR and 26 SR procedures were performed, with both procedures performed in two women. The Bland–Altman plots showed that there were no systematic differences between TVS or MRICenter when compared with IOM for all included participants. MRIDirect systematically underestimated LAVD for lesions located further from the anal verge. TVS, MRICenter and MRIDirect had LoA outside the preset clinically acceptable difference when compared with IOM. LAVD was within the clinically acceptable difference from IOM of ± 20 mm in 70% (33/47) of women on TVS, 72% (34/47) of women on MRICenter and 47% (22/47) of women on MRIDirect.ConclusionsTVS should be the preferred method to estimate the location of a rectosigmoid endometriotic lesion, i.e. LAVD, as it is more available, less expensive and has a similar accuracy to that of MRI. Estimating LAVD can be relevant for planning colorectal surgery for rectosigmoid endometriosis. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Successful management of colonic pythiosis in two dogs in Thailand using antifungal therapy
Authors: Sukanan Pornphan , Suparp Bongkot , Yongsiri Supattra , Chansiripornchai Piyarat , Kesdangsakonwut Sawang 
Published: September 2022

AbstractGastrointestinal pythiosis is a severe, progressive and often a fatal disease, which is caused by the aquatic pathogen Pythium insidiosum. Treatment is challenging due to the disease's resistance to antifungal drugs. Surgical resection is frequently attempted in cases of pythiosis; however, it can be technically challenging. This report presents two dogs with decreased appetite, abdominal pain, progressive haematochezia, tenesmus and significant weight loss. With the medical histories of both being young canines, living in areas with access to natural water resources and with the main chronic gastrointestinal symptoms having not responded to symptomatic treatment, pythiosis was taken into consideration. Abdominal ultrasound revealed severe, diffuse thickening and loss of normal layering of the colonic wall. These findings led to a differential diagnosis between intestinal neoplasia and fungal disease. Full‐thickness biopsies were later performed, and immunohistochemistry staining was suggested for colonic pythiosis. Medical treatment for pythiosis was successful with a combination of oral terbinafine and prednisolone. However, therapy with itraconazole in case 1 did not improve the clinical signs, and in case 2, itraconazole was used after all clinical signs have improved for clinical control. Since then, there has been no recurrence of clinical signs until the time of preparing this report (19 months for case 1, 11 months for case 2 since the cessation of treatment). The treatment was successful based on clinical signs and ultrasonographic data, and the disease remission was not confirmed by advance imaging, monitoring of pythiosis enzyme‐linked immunosorbent essay concentration or repeat sampling.
Hodge duality between stress space and strain space in anisotropic media
Authors: Yajima Takahiro , Nagahama Hiroyuki 
Published: September 2022

AbstractDuality in a linear elasticity theory is studied based on a theory of differential form. A generalized expression of a Hodge star operator with an index is introduced. The index in the Hodge star operator means a superposition of ordinary Hodge star operators. By using the superposed Hodge star operator, a linear constitutive relation in anisotropic media can be expressed as a duality between a stress and strain spaces. Then, a basic elastodynamic equation is derived from the conservation law and the linear constitutive relation in the stress and strain spaces. Moreover, a geometric expression of equation of stress function and displacement function is derived by using the differential form and the dual relation of linear constitutive relation. These geometric results imply that the approach of differential forms is applicable to an analysis of deformation in anisotropic media. The superposed Hodge star operator discussed in this study has similar properties of a discrete Hodge operator, which represents the summation of differential forms on the decomposed regions. This means that the superposed Hodge star operator and the discrete Hodge operator express the constitutive relation in which physical quantities act on each other.
Nature-Based Climate Solutions in European Schools: A Pioneering Co-designed Strategy Towards Urban Resilience
Authors: Baró Francesc , Camacho David A. , Perez del Pulgar Carmen , Ruiz-Mallén Isabel , García-Serrano Pablo 
Published: September 2022

AbstractAs cities around the world are increasingly facing the impacts of climate change, a growing number of municipalities are leading collaborative projects to adapt schools to rising temperatures. The implementation of nature-based solutions (NBS) is highlighted as an important component to be included in these initiatives given their multifunctional and cost-effective character. However, the challenges and upscaling opportunities of these pioneering projects are still not well understood nor systematically studied on a comparative basis. This study explores and compares three European pilot nature-based projects aiming to make schools more resilient to climate change impacts while creating other co-benefits for children and the wider local community. These projects are Oasis (Paris), Climate Shelters (Barcelona) and Care in School Environments (Madrid). Building on a framework for assessing the co-benefits of urban NBS, the comparative analysis explores the selection criteria of schools and their equity implications, the multifunctional role of NBS beyond climate adaptation, the main aspects and challenges related to the co-design process and the subsequent project implementation and the potential for upscaling at the city level. Based on this exploration, we contend that nature-based climate adaptation projects in schools can be a spearhead for a wider community-based strategy towards urban resilience.
Reporting CCI and Learning Technology Research
Authors: Giannakos Michail 
Published: September 2022

AbstractDesigning and conducting high quality research is extremely important in CCI and learning technology research. However, the same high-quality needs to be followed during the reporting of the work. At the end of the day, this what the reviewers and readers will credit – therefore, reporting is of equal importance. This chapter provides information on how you should structure your article and the information that is usually required. This chapter is intended to serve as a template for CCI and learning technology researchers. Moreover, I have summarized some recommendations based on my experience, as well as on published guidelines and recommendations from neighboring fields.
BPS correlators for AdS3/CFT2
Authors: Gaberdiel Matthias R. , Nairz Beat 
Published: September 2022

Abstract
The BPS correlators of the symmetric product orbifold SymN(𝕋4) are reproduced from the dual worldsheet theory describing strings on AdS3× S3× 𝕋4 with minimal (k = 1) NS-NS flux. More specifically, we show that the worldsheet duals of the symmetric orbifold BPS states can be identified with their lift to the covering surface, thereby making the matching of the correlators essentially manifest. We also argue that the argument can be generalised to arbitrary descendants, using suitable DDF operators on the worldsheet.
Similar rate of return to sports activity between posterior-stabilised and cruciate-retaining primary total knee arthroplasty in young and active patient
Authors: D’Ambrosi Riccardo , Mangiavini Laura , Loucas Rafael , Loucas Marios , Brivio Angela , Mariani Ilaria , Ursino Nicola , Migliorini Filippo 
Published: September 2022

Abstract
Purpose
Cruciate-retaining and posterior-stabilised implant designs are available for primary total knee arthroplasty. However, whether the implant design is associated with a difference in the level of activity still remains unclear. This clinical trial compared posterior-stabilised and cruciate-retaining implants in sport-related patient-reported outcome measures, range of motion, rate of return to sport, and weekly time dedicated to sport in active adults. It was also hypothesised that in young and active patients both implants lead to a similar rate of return to sport in terms of hours per week, type of sport, and joint mobility.

Methods
All patients were evaluated preoperatively and for a minimum of 36 months follow-up. The University of California Los Angeles activity scores, High-Activity Arthroplasty Score, and Visual Analogue Scale were administered preoperatively and at the last follow-up. The range of motion was investigated at admission and the last follow-up. Data concerning the hours per week dedicated to sports and the type of sport practiced were also collected at admission and at the last follow-up. The Kaplan–Meier Curve was performed to compare implant survivorship.

Results
Data from 227 procedures (cruciate-retaining: 109, posterior-stabilised: 118) were prospectively collected. At the last follow-up, no difference was reported in The University of California Los Angeles activity scores (p = 0.6), High-Activity Arthroplasty Score (p = 0.1), Visual Analogue Scale (p = 0.9), flexion (p = 0.7) and extension (p = 0.4). No difference was found in the rate of return (p = 0.1) and weekly hours dedicated to sport (p = 0.3). The Kaplan–Meier curve evidenced no statistically significant difference in implant survivorship (p = 0.6).

Conclusions
At approximately five years of follow-up, no difference was reported between cruciate-retaining and posterior-stabilised implants in active adults in sport-related patient-reported outcomes measures, range of motion, pain, weekly time dedicated to sport, rate of return to sport, and implant survivorship.

Level of evidence
Level II, prospective study.
Slow-oscillatory tACS does not modulate human motor cortical response to repeated plasticity paradigms
Authors: Bradley Claire , Elliott Jessica , Dudley Samuel , Kieseker Genevieve A. , Mattingley Jason B. , Sale Martin V. 
Published: September 2022

AbstractPrevious history of activity and learning modulates synaptic plasticity and can lead to saturation of synaptic connections. According to the synaptic homeostasis hypothesis, neural oscillations during slow-wave sleep play an important role in restoring plasticity within a functional range. However, it is not known whether slow-wave oscillations—without the concomitant requirement of sleep—play a causal role in human synaptic homeostasis. Here, we aimed to answer this question using transcranial alternating current stimulation (tACS) to induce slow-oscillatory activity in awake human participants. tACS was interleaved between two plasticity-inducing interventions: motor learning, and paired associative stimulation (PAS). The hypothesis tested was that slow-oscillatory tACS would prevent homeostatic interference between motor learning and PAS, and facilitate plasticity from these successive interventions. Thirty-six participants received sham and active fronto-motor tACS in two separate sessions, along with electroencephalography (EEG) recordings, while a further 38 participants received tACS through a control montage. Motor evoked potentials (MEPs) were recorded throughout the session to quantify plasticity changes after the different interventions, and the data were analysed with Bayesian statistics. As expected, there was converging evidence that motor training led to excitatory plasticity. Importantly, we found moderate evidence against an effect of active tACS in restoring PAS plasticity, and no evidence of lasting entrainment of slow oscillations in the EEG. This suggests that, under the conditions tested here, slow-oscillatory tACS does not modulate synaptic homeostasis in the motor system of awake humans.
Bromelain-based enzymatic burn debridement: Spanish multidisciplinary consensus
Authors: Serracanta Jordi , Baena Jacinto , Martinez-Mendez José R. , Sanchez-Sanchez Manuel , Lopez-Suso Eugenia , Galeiras Rita , Perez-del-Caz Maria Dolores , Vivo-Benlloch Carmen , Monclus-Fuertes Enrique , Casalduero-Viu Jacobo , Martin-Playa Patricia , Ugalde-Gutierrez Marta , Gacto-Sanchez Purificacion , Rincon-Ferrari Maria Dolores , Piqueras-Perez Jose Maria , Martin-Luengo Ana 
Published: September 2022

Abstract

Background
Bromelain-based enzymatic debridement is gaining increased interest from burn specialists in the last few years. The objective of this manuscript is to update the previous, first Spanish consensus document from 2017 (Martínez-Méndez et al. 43:193–202, 2017), on the use of enzymatic debridement with NexoBrid® in burn injuries, adding the clinical experience of a larger panel of experts, integrating plastic surgeons, intensivists, and anesthesiologists.

Methods
A consensus guideline was established by following a modified Delphi methodology of a 38-topic survey in two rounds of participation. Items were grouped in six domains: general indication, indication in critical patients, pain management, conditions for NexoBrid® application, NexoBrid® application technique, and post-debridement wound care.

Results
In the first round, experts established consensus (strongly agree or agree) on 13 of the 38 statements. After the second round, a consensus was reached on 24 of the 25 remaining statements (97.2%).

Conclusions
The present updated consensus document provides recommendations on the use of bromelain-based enzymatic debridement NexoBrid®, integrating the extensive clinical experience of plastic surgeons, intensivists, and anesthesiologists in Spain. Further clinical trials and studies are required to corroborate, modify, or fine tune the current statements.

Level of evidence: Not ratable
Metal implants on abdominal CT: does split-filter dual-energy CT provide additional value over iterative metal artifact reduction?
Authors: Wichtmann Hildegard M. , Laukamp Kai R. , Manneck Sebastian , Appelt Konrad , Stieltjes Bram , Boll Daniel T. , Benz Matthias R. , Obmann Markus M. 
Published: September 2022

Abstract
Purpose
To assess image quality and metal artifact reduction in split-filter dual-energy CT (sfDECT) of the abdomen with hip or spinal implants using virtual monoenergetic images (VMI) and iterative metal artifact reduction algorithm (iMAR).

Methods
102 portal-venous abdominal sfDECTs of patients with hip (n = 71) or spinal implants (n = 31) were included in this study. Images were reconstructed as 120kVp-equivalent images (Mixed) and VMI (40–190 keV), with and without iMAR. Quantitative artifact and image noise was measured using 12 different ROIs. Subjective image quality was rated by two readers using a five-point Likert-scale in six categories, including overall image quality and vascular contrast.

Results
Lowest quantitative artifact in both hip and spinal implants was measured in VMI190keV-iMAR. However, it was not significantly lower than in MixediMAR (for all ROIs, p = 1.00), which were rated best for overall image quality (hip: 1.00 [IQR: 1.00–2.00], spine: 3.00 [IQR:2.00–3.00]). VMI50keV-iMAR was rated best for vascular contrast (hip: 1.00 [IQR: 1.00–2.00], spine: 2.00 [IQR: 1.00–2.00]), which was significantly better than Mixed (both, p < 0.001). VMI50keV-iMAR provided superior overall image quality compared to Mixed for hip (1.00 vs 2.00, p < 0.001) and similar diagnostic image quality for spinal implants (2.00 vs 2.00, p = 0.51).

Conclusion
For abdominal sfDECT with hip or spinal implants MixediMAR images should be used. High keV VMI do not further improve image quality. IMAR allows the use of low keV images (VMI50keV) to improve vascular contrast, compared to Mixed images.

Graphical abstract