bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for Bakri balloon tamponade failure in the management of postpartum hemorrhage
Authors: Xu Tian‐yi , Fu Qin 
Published: July 2022

AbstractObjectiveTo predict risk factors for Bakri balloon tamponade (BBT) failure in the management of postpartum hemorrhage (PPH).MethodsThe data of 599 patients who underwent BBT were retrospectively analyzed from January 1, 2017 to December 31, 2021 in a tertiary hospital in Shanghai, East China. The patients were divided into the failure group and the success group. Failure was defined as the inability to control bleeding, which required surgical interventions. Maternal characteristics, PPH characteristics, PPH management approaches, and maternal complications were compared between the groups. The independent predictors of BBT failure were analyzed by logistic regression analysis.ResultsThe overall success rate of BBT was 83.0% (497/599). The blood loss before and after balloon insertion in the failure group was significantly greater than that in the success group. Of the 102 failures, B‐Lynch suture was performed in one patient, uterine artery embolization was performed in 99 patients (with one failure), and total hysterectomy was performed in three patients. Some risk factors, including twin gestation (odds ratio [OR] 9.68), placenta accreta spectrum with/without placenta previa (OR 4.45), estimated blood loss at least 1135 ml at balloon insertion (OR 3.35), multiparous (OR 2.72), and in vitro fertilization‐embryo transfer (OR 2.00) were strongly associated with BBT failure.ConclusionBBT seemed to be a less effective tool in the management of PPH due to placenta accreta spectrum with/without placenta previa and twin gestation.
Lower gastrointestinal function after surgery for deep endometriosis: A prospective cohort study
Authors: Dior Uri P. , Reddington Charlotte , Cheng Claudia , Levin Gabriel , McInerney Carmel , Moss Alan , Healey Martin 
Published: July 2022

AbstractObjectiveTo prospectively compare long‐term lower gastrointestinal function before and after laparoscopic surgery for deep endometriosis (DE).MethodsIn this prospective observational study we followed 149 patients with confirmed DE who were treated surgically. Patients completed the International Consultation on Incontinence Questionnaire Anal Incontinence Symptoms and Quality of Life Module (ICIQ‐B) before surgery, and 6 weeks, 6 months, and 12 months after surgery. Bowel pattern, bowel control, and bowel impact on quality of life summary scores were compared before and after surgery.ResultsBowel pattern score showed an increasing improvement at all time points after surgery, from a mean pre‐operation score of 4.8 ± 2.0 to 4.4 ± 1.8 at 6 weeks, 4.2 ± 1.8 at 6 months, and 4.2 ± 1.2 at 12 months. Bowel impact on quality of life significantly improved from pre‐surgery mean score of 5.5 ± 6.0 to 4.2 ± 5.5 at 6 weeks and 4.4 ± 5.4 at 6 months. Direct lower gastrointestinal endometriosis involvement and worse initial function were associated with larger improvements in scores following surgery.ConclusionsLower gastrointestinal function significantly improved after surgical treatment of DE. Further research is needed to confirm our findings and to better characterize the sub‐groups of patients for whom surgery will have a beneficial effect on their bowel function.
A rare case of pyoderma gangrenosum occurring at the site of laparoscopic port following laparoscopic radical nephrectomy
Authors: Ogasawara Takuto , Fukuta Fumimasa , Fujita Miri , Tachiki Hitoshi , Shindo Tetsuya , Kato Junji , Uhara Hisashi , Masumori Naoya 
Published: July 2022

IntroductionPyoderma gangrenosum is a rare dermatological disease associated with underlying inflammatory conditions.Case presentationA 59‐year‐old man was diagnosed with right renal cancer cT1aN0M0 and laparoscopic right radical nephrectomy was performed. Five days after surgery, he had a high‐grade fever, surgical site flare, and severe pain. At first, we diagnosed surgical site infection and wound dehiscence. Despite treatment for infection, his general condition and dermatological symptoms did not improve. Thereafter, a dermatologist advised us to perform a skin biopsy and blood culture examinations. Finally, the man was diagnosed with pyoderma gangrenosum according to the pathology of the skin biopsy and negative blood culture. After both intravenous administration of predonisolone and a topical corticosteroid, the high‐grade fever and dermatological symptoms improved greatly.ConclusionAlthough pyoderma gangrenosum is a rare disease, we should bear in mind the disease since the treatment strategy is completely different from that for surgical site infection.
A hydrogel platform for co‐delivery of immunomodulatory proteins for pancreatic islet allografts
Authors: Medina Juan D. , Barber Graham F. , Coronel Maria M. , Hunckler Michael D. , Linderman Stephen W. , Quizon Michelle J. , Ulker Vahap , Yolcu Esma S. , Shirwan Haval , García Andrés J. 
Published: July 2022

AbstractType 1 diabetes (T1D), an autoimmune disorder in which the insulin‐producing β‐cells in the islets of Langerhans in the pancreas are destroyed, afflicts over 1.6 million Americans. Although pancreatic islet transplantation has shown promise in treating T1D, continuous use of required immunosuppression regimens limits clinical islet transplantation as it poses significant adverse effects on graft recipients and does not achieve consistent long‐term graft survival with 50%–70% of recipients maintaining insulin independence at 5 years. T cells play a key role in graft rejection, and rebalancing pathogenic T effector and protective T regulatory cells can regulate autoimmune disorders and transplant rejection. The synergy of the interleukin‐2 (IL‐2) and Fas immunomodulatory pathways presents an avenue for eliminating the need for systemic immune suppression by exploiting IL‐2's role in expanding regulatory T cells and leveraging Fas ligand (FasL) activity on antigen‐induced cell death of effector T cells. Herein, we developed a hydrogel platform for co‐delivering an analog of IL‐2, IL‐2D, and FasL‐presenting microgels to achieve localized immunotolerance to pancreatic islets by targeting the upregulation of regulatory T cells and effector T cells simultaneously. Although this hydrogel provided for sustained, local delivery of active immunomodulatory proteins, indefinite allograft survival was not achieved. Immune profiling analysis revealed upregulation of target regulatory T cells but also increases in Granzyme B‐expressing CD8+ T cells at the graft site. We attribute the failed establishment of allograft survival to these Granzyme B‐expressing T cells. This study underscores the delicate balance of immunomodulatory components important for allograft survival – whose outcome can be dependent on timing, duration, modality of delivery, and disease model.
Association between relational mobility, brain structure, and prosociality in adolescents
Authors: Yamada Junko , Shou Qiulu , Miyazaki Atsushi , Matsuda Tetsuya , Takagishi Haruto 
Published: July 2022

AbstractTrust plays a vital role in human society. Previous studies have suggested that trust comprises general trust and caution. General trust is a belief that others, in general, are trustworthy, and caution is a belief in the importance of vigilance in dealing with others. Adolescence is a critical period for establishing these psychological traits. It is a period of physical and mental development, and the social environment during this period influences adolescents' psychology, including their brain structures. In this study, we focus on relational mobility as a socio‐environmental factor that influences the development of adolescents' psychology and the brain. Relational mobility refers to the degree of freedom to choose and replace social relationships and consists of two subfactors (the degree of freedom to choose and replace social relationships and the number of opportunities to meet new people). Accordingly, we analyzed each subfactor separately. Results showed that the degree of freedom to choose and replace social relationships was only negatively associated with caution and left posterior superior temporal gyrus (pSTG) volume in adolescents. Furthermore, the effect of the freedom to choose and replace social relationships on caution was significantly relevant to the left pSTG volume. In contrast, the degree of opportunities to meet new people was associated with neither general trust nor caution, whereas it was positively associated with the right supramarginal gyrus volume. This study suggests that the social environment during adolescence influences brain structures related to prosociality.
Comparative vegetative anatomy of three Elaeocarpus species from the Western Ghats, Southern India
Authors: Yuvarani Seenu , Karthik Shanmugam , Koshila Ravi Ravichandran , Muthukumar Thangavelu 
Published: July 2022

AbstractThe vegetative anatomy of Elaeocarpus angustifolius Blume, Elaeocarpus tuberculatus Roxb., and Elaeocarpus variabilis Zmarzty were investigated to illustrate anatomical variations. Plant materials were free‐hand sectioned using a razor blade and stained with different staining solutions. The maceration technique was used to assess stomatal characteristics. Elaeocarpus leaves have abaxial epidermis with paracytic stomata and curved anticlinal walls in E. angustifolius, straight walls in other two species. Trichomes were absent in E. angustifolius.hav Mesophyll dorsiventral, midvein cortex contains starch grains, and vascular tissues enclosed by thick‐walled sclerenchymatous cells. The petioles of all the three species possess unicellular epidermal hairs, collenchymatous hypodermis, and cortex containing druses and crystals, and vascular tissue enclosed by sclerenchymatous fibers. Water‐storage cells are absent in petioles of E. angustifolius. Anatomical features of Elaeocarpus stem include epidermal hairs, epidermis covered by thin cuticle, the collenchymatous hypodermis and vascular integrity with entire cylinder enclosed by sclerenchymatous fibers. Pith contains water‐storage cells. Starch grains absent in the pith cells of E. tuberculatus. The roots of Elaeocarpus possess unicellular root hairs, cortex 12–14 layered in E. tuberculatus and E. variabilis and 10–12 layerd E. angustifolius, Endodermis O‐thickened and pericycle single‐layered in all the examined Elaeocarpus species. Vascular bundles are arranged radially. Lignin deposition occurred in stellar region of roots. Water‐storage cells present in the stelar regions of E. variabilis. The study revealed significant anatomical differences between the three Elaeocarpus species and most of these anatomical features may be used as markers for the identification of these species.Research Highlights
Comparative anatomy of three south Indian Elaeocarpus was studied.
Leaf mesophyll layers varied in all the Elaeocarpus species.
Crystals was present in petiole of all examined Elaeocarpus species.
Starch grains was absent in stems of E. tubercuatus, but present in E. variabilis.
Water‐storage cells observed in stellar region of E. variabilis.
New and convergent synthesis of erdafitinib
Authors: Xu Zhiyong , Wang Han , Jiang Shun , Lu Sheng , Mao Yongjun 
Published: July 2022

AbstractA new and convergent synthetic route of erdafitinib on a 20 g scale has been developed, from the commercially available chemicals quinoxalin‐2‐ol, 4‐bromo‐1‐methyl‐1H‐pyrazole, and 2‐bromo‐1,1‐dimethoxyethane. The key intermediate 3,5‐dimethoxyphenyl‐isopropylethane‐1,2‐diamine (17) was prepared from 2‐bromo‐1,1‐dimethoxyethane in 89% yield over two steps and 98.8% purity. Erdafitinib was obtained from 7‐bromo‐2‐(1‐methyl‐1H‐pyrazol‐4‐yl) quinoxaline (8) and 17 in 89% yield and 99.4% purity. There are seven steps in this convergent synthesis route and the overall yield is 54%.
β‐Cyclodextrin‐catalyzed synthesis, characterization, and bacterial evaluation of spirochromanone‐linked 1,2,3‐triazole and spirochromanone conjugates containing bis‐1,2,3‐triazoles
Authors: Madhuri Eluri Venkata Lakshmi , Sarasija Madderla , Ashok Dongamanti 
Published: July 2022

AbstractSpirochromanone linked 1,2,3‐triazoles and spirochromanone conjugates containing bis‐1,2,3‐triazoles were synthesized for the first time and are evaluated for possible anti‐bacterial activity. In this work, preparation of triazole moieties mediated by a catalytic amount of β‐cyclodextrin starting from propargylated spirochromanone is reported. The approach involves a simple, efficient click chemistry method, inexpensive phase transfer catalyst, and uses a green solvent. Though the activity is less promising, it paves a route for preparation of Spirochromanone linked 1,2,3‐triazoles and spirochromanone conjugates containing bis‐1,2,3‐triazoles, where structural modification can possibly result in compounds with better activity. All the compounds were characterized by 1H NMR, 13C NMR, and mass spectral studies.
Synthesis, characterization, biological evaluation, and computational study of benzimidazole hybrid thiosemicarbazide derivatives
Authors: Acharya Prachi T. , Bhavsar Zeel A. , Jethava Divya J. , Rajani Dhanji P. , Pithawala Edwin , Patel Hitesh D. 
Published: July 2022

AbstractThe antimicrobial, anti‐tubercular, antimalarial, and antioxidant properties of a series of benzimidazole hybrid thiosemicarbazide derivatives (7a–o) were investigated in vitro. IR, 1H‐NMR, 13C‐NMR, and ESI‐MS spectra were used to describe and elucidate the synthesized compounds. The majority of the compounds studied have excellent antibacterial and antioxidant properties. In addition, an in silico investigation was conducted. By calculating ADME‐Tox descriptors, all freshly synthesized molecules were shown to have outstanding pharmacokinetic properties, indicating that these derivatives could be used as a basis for the development of some novel active drugs. A SAR (structure–activity relationship) was also briefly described
Synthesis of N‐acetyl‐l‐aspartyl‐l‐glutamic acid; [3H]NAAG
Authors: Kriegelstein Michal , Marek Aleš 
Published: July 2022

[3H]NAAG, N‐acetyl‐l‐aspartyl‐l‐glutamic acid, has been widely used as a substrate in glutamate carboxypeptidase II (GCPII) reactions, either to determine the inhibitory constants at 50% inhibition (IC50) of novel compounds or to measure GCPII activities in different tissues harvested from various disease models. The importance of [3H]NAAG, combined with its current commercial unavailability, prompted the development of a reliable eight‐step synthetic procedure towards [3H2]NAAG starting from commercially available pyroglutamate. Pure [3H]NAAG of high molar activity (49.8 Ci/mmol) and desired stereochemistry was isolated in high radiochemical yield (67 mCi) and radiochemical purity (>99%). The identity was confirmed by mass spectrometry and co‐injection with unlabeled reference.
Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review
Authors: Suárez‐López del Amo Fernando , Monje Alberto 
Published: July 2022

AbstractBackgroundThe use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous blood‐derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB), and recombinant human bone morphogenetic protein‐2 (rhBMP‐2), on the outcomes of ARP/ARR and ISD therapy (i.e., alveolar ridge augmentation [ARA] and maxillary sinus floor augmentation [MSFA]).MethodsAn electronic search for eligible articles published from January 2000 to October 2021 was conducted. Randomized clinical trials evaluating the efficacy of ABPs, EMD, rhBMP‐2, and rhPDGF‐BB for ARP/ARR and ISD were included according to pre‐established eligibility criteria. Data on linear and volumetric dimensional changes, histomorphometric findings, and a variety of secondary outcomes (i.e., clinical, implant‐related, digital imaging, safety, and patient‐reported outcome measures [PROMs]) were extracted and critically analyzed. Risk of bias assessment of the selected investigations was also conducted.ResultsA total of 39 articles were included and analyzed qualitatively. Due to the high level of heterogeneity across studies, quantitative analyses were not feasible. Most studies in the topic of ARP/ARR revealed that the use of biologics rendered similar results compared with conventional protocols. However, when juxtaposed to unassisted healing or socket filling using collagen sponges, the application of biologics did contribute to attenuate post‐extraction alveolar ridge atrophy in most investigations. Additionally, histomorphometric outcomes were positively influenced by the application of biologics. The use of biologics in ARA interventions did not yield superior clinical or radiographic outcomes compared with control therapies. Nevertheless, ABPs enhanced new bone formation and reduced the likelihood of early wound dehiscence. The use of biologics in MSFA interventions did not translate into superior clinical or radiographic outcomes. It was observed, though, that the use of some biologics may promote bone formation during earlier stages of healing. Only four clinical investigations evaluated PROMs and reported a modest beneficial impact of the use of biologics on pain and swelling. No severe adverse events in association with the use of the biologics evaluated in this systematic review were noted.ConclusionsOutcomes of therapy after post‐extraction ARP/ARR and ARA in edentulous ridges were comparable among different therapeutic modalities evaluated in this systematic review. Nevertheless, the use of biologics (i.e., PRF, EMD, rhPDGF‐BB, and rhBMP‐2) in combination with a bone graft material generally results into superior histomorphometric outcomes and faster wound healing compared with control groups.
MA‐cont:pre/post effect size: An interactive tool for the meta‐analysis of continuous outcomes using R Shiny
Authors: Papadimitropoulou Katerina , Riley Richard D. , Dekkers Olaf M. , Stijnen Theo , le Cessie Saskia 
Published: July 2022

AbstractMeta‐analysis is a widely used methodology to combine evidence from different sources examining a common research phenomenon, to obtain a quantitative summary of the studied phenomenon. In the medical field, multiple studies investigate the effectiveness of new treatments and meta‐analysis is largely performed to generate the summary (average) treatment effect. In the meta‐analysis of aggregate continuous outcomes measured in a pretest‐posttest design using differences in means as the effect measure, a plethora of methods exist: analysis of final (follow‐up) scores, analysis of change scores and analysis of covariance. Specialised and general‐purpose statistical software is used to apply the various methods, yet, often the choice among them depends on data availability and statistical affinity. We present a new web‐based tool, MA‐cont:pre/post effect size, to conduct meta‐analysis of continuous data assessed pre‐ and post‐treatment using the aforementioned approaches on aggregate data and a more flexible approach of generating and analysing pseudo individual participant data. The interactive web environment, available by R Shiny, is used to create this free‐to‐use statistical tool, requiring no programming skills by the users. A basic statistical understanding of the methods running in the background is a prerequisite and we encourage the users to seek advice from technical experts when necessary.
Investigation of text‐mining methodologies to aid the construction of search strategies in systematic reviews of diagnostic test accuracy—a case study
Authors: O'Keefe Hannah , Rankin Judith , Wallace Sheila A. , Beyer Fiona 
Published: July 2022

AbstractCurrent methodologies for designing search strategies rely heavily on the knowledge and expertise of information specialists. Yet, the volume and complexity of scientific literature is overwhelming for even the most experienced information specialists, making it difficult to produce robust search strategies for complex systematic reviews. In this case study, we aimed to assess and describe the benefits and limitations of using semi‐automated text‐mining tools for designing search strategies in a systematic review of diagnostic test accuracy. An experienced information specialist designed a search strategy using traditional methods. This strategy was then amended to include additional terms identified by text‐mining tools. We evaluated the usability and expertise required, risk of introducing bias to the search, precision of the search strategy and rated the usefulness of the tools. Thirteen of the 16 investigated tools produced a total of 40 additional terms, beyond those in the original search strategy. This resulted in 11 previously unidentified relevant articles being retrieved. Precision was reduced or remained the same in all cases. After considering all aspects of the investigation we rated each application, with two being ‘extremely useful’, three being ‘useful’, three having ‘no impact’ and eight being ‘not very useful’. Comparative analysis revealed discrepancies between similar tools. Our findings have implications for the way in which these methodologies are used and applied to search strategies. If semi‐automated techniques are to become mainstream in information retrieval for complex systematic reviews, we need tailored tools that fit information specialists' requirements across disciplines.
Documentation in Pediatric Microlaryngoscopy/Bronchoscopy: International Modified Delphi Consensus
Authors: Neocleous Penelope , Dzioba Agnieszka , Strychowsky Julie , Husein Murad , Propst Evan J. , Nguyen Lily HP , Wolter Nikolaus E. , You Peng , Choi Sukgi , Torre Michele , Zalzal George , Parikh Sanjay , Mehta Deepak , Graham M. Elise ,   the Pediatric Bronchoscopy Working Group
Published: July 2022

BackgroundComplete and accurate documentation of surgical procedures is essential for optimizing patient care, yet significant variation in operative notes persists within and across institutions. We sought to reach consensus on the most important components of an operative note for pediatric microlaryngoscopy and bronchoscopy.MethodsA modified Delphi consensus process was used. A checklist for operative documentation, created by fellowship‐trained pediatric otolaryngologists‐head and neck surgeons, was sent to surgeons identified as experts in pediatric laryngoscopy and bronchoscopy. In the first round, items were rated as “keep” or “remove”. In the second round, each item was rated on a 7‐point Likert scale for importance. The mean score of each item was calculated to determine if consensus was reached.ResultsOverall, 43/74 (58.1%) surgeons responded to our survey. After two rounds of editing, 28 components reached consensus, 24 were near consensus, and 26 did not reach consensus. Items that reached final consensus had mean (SD) ratings of 6.12 (0.94) (range, 5.31–6.72).ConclusionPediatric otolaryngologists identified as bronchoscopy experts were able to create a checklist of essential components of an operative note for pediatric laryngoscopy and bronchoscopy using a Delphi method. Items reaching consensus included procedure name, description of breathing, grade of airway view, description of normal anatomic structures, grade of subglottic stenosis if present, presence and description of tracheobronchomalacia, presence of fistulae, cleft and rings, and several special cases including foreign body and tracheostomy management, as well as end of procedure disposition and complications.Level of Evidence5 Laryngoscope, 133:1234–1238, 2023