bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEKUATAN HUKUM SURAT REKOMENDASI KOMNAS HAM DALAM PROSES PENEGAKAN HAM DI INDONESIA (Studi Surat Rekomendasi Komnas HAM Nomor: 003/Humas/KH/I/2021 dalam Kasus Penembakan Laskar Front Pembela Islam)
Authors: Laksana Ananda Cahya , Liany Lusy , Maulana Aya Yahya 
Published: October 2022

Di Indonesia masih terdapat pelanggaran Hak Asasi Manusia dimana terdapat beberapa kasus yang dilakukan oleh aparat penegak hukum sendiri. Kasus yang penulis bahas kali ini mengenai peristiwa penembakan oleh anggota Kepolisian kepada anggota Laskar Front Pembela Islam (FPI) dimana penulis membahas bagaimana kekuatan Hukum Rekomendasi Komnas HAM dan tindaklanjut dari surat Rekomendasi Komnas HAM dalam kasus tersebut serta Pandangan Hukum Islam terkait proses pelaku pelanggaran Hak Asasi Manusia. Penelitian ini menggunakan penelitian normatif dengan pendekatan peraturan perundang-undangan dan pendekatan kasus. Dari penelitian ini tergambar bahwasannya kekuatan Hukum Rekomendasi Komnas HAM yang belum mempunyai kekuatan hukum mengikat untuk ditindaklanjuti dalam Undang-Undang Nomor 39 Tahun 1999 tentang HAM serta masih lemahnya komitmen penyelesaian kasus pelanggaran HAM baik dari berbagai pihak dalam menuntaskan, melindungi, dan menegakan Hak Asasi Manusia di Indonesia. Dalam Hukum Islam telah diatur didalam Al-Quran dan Hadits soal qisas berkaitan dengan kasus yang penulis angkat. Maka dari pada itu saran dari penulis, Pertama, perlunya pengaturan kekuatan hukum surat Rekomendasi Komnas HAM diatur mengikat dalam UU HAM. Kedua, penguatan kedudukan dan kewenangan terhadap Komnas HAM dengan dibuatkan undang-undang khusus serta menjadikan Pengadilan Hak Asasi Manusia sejajar dengan peradilan lainnya.
Komisz-e a comics?
Authors: Vörös Klára 
Published: October 2022

A tanulmány azt vizsgálja, hogy egyazon tartalmon hogyan osztozik meg a szónyelv és a képnyelv. Az ószövetségi József és testvérei című történet kút-epizódját elemzi abból a szempontból, hogy a bibliai történetből mi reprezentálódik képregényes feldolgozásában, melyek a leszűrt, kiemelt alakzatok. Sokat bíz-e az értelmezőre a képregény, vagy éppen betölt olyan hiányokat is, amelyek a prózában üresek akartak maradni? Mindezek előtt a tanulmány felsorol kilenc jellemzőt, amelyet a képregény jogosan birtokol, s ami alapján művészeti entitásnak nevezhető, szemben a gyakori vélekedéssel, mely szerint a képregény egyike a művészet aranykora utáni kommersz kísérleteknek. A lényegi kérdés: mi történik az adaptáció során? A képregény a könnyebbik utat választja, vagyis csupán hatékony, könnyen befogadható elbeszélője akar lenni a bibliai szövegnek, vagy gondolkodó társként vesz részt a történet közvetítésében?
Effect of Leadership Style and Entrepreneurship Orientation on the Performance of Village Owned Business Entities (BUMDes) in Bengkalis Regency
Authors: Velia Ayu Sasqia  
Published: October 2022

Village-Owned organisations (BUMDes) are one of the efforts to expand the village economy. BUMDes are set up on the basis of the wishes and capability of the village as an attempt to enhance the welfare of the network community. therefore, it is very important in an effort to make sure the achievement of BUMDes with the intention to gain superior overall performance. This look at goals to decide the impact of leadership style and entrepreneurial orientation on the performance of BUMDes in Bengkalis Regency. facts became accrued the usage of a questionnaire dispensed to the BUMDes director, BUMDes secretary or treasurer and BUMDes supervisors. Data was amassed with the aid of distributing questionnaires given to 303 respondents, however most effective 261 (86.14%) of respondents filled out the questionnaire completely and can be processed. The analytical device used is multiple linear regression analysis the usage of SPSS version 23. This observe uses quantitative statistics. The supply of data used in this study is primary statistics and data series is carried out directly using a questionnaire that is measured using a Likert scale. The outcomes of this examine suggest that the variables of management style, and entrepreneurial orientation have an effect at the overall performance of BUMDes.
Protective effects of silibinin on LPS-induced inflammation in human periodontal ligament cells
Authors: Meng Di , Wang Yuling , Liu Tongjun 
Published: October 2022

Clinically, periodontitis is a chronic nonspecific inflammation that leads to damaged teeth and their supporting gum tissues. Although many studies on periodontitis have been conducted, therapy with natural products is still rare. Silibinin has been proven to have anti-inflammatory and antioxidant activities. However, the effects of silibinin on lipopolyssacharide (LPS)-induced inflammation in periodontal ligaments (PDLs) have not yet been investigated. In this study, the PDLs were treated with silibinin (10, 20, and 40 μM) in the presence of LPS. The results showed that silibinin treatment reduced the levels of NO, PGE2, IL-6, TNF-α, MMP-1, and MMP-3 and enhanced the activities of superoxide dismutase (SOD) and glutathione (GSH). Moreover, silibinin treatment downregulated RANKL levels and upregulated OPG and ALP levels. In summary, silibinin protected PDLs against LPS-induced inflammation, oxidative stress, and osteogenic differentiation.
Ruthenium polypyridine complexes with triphenylamine groups as antibacterial agents against Staphylococcus aureus with membrane-disruptive mechanism
Authors: Jiang Li , Ma Yuanyuan , Xiong Yanshi , Tan Yanhui , Duan Xuemin , Liao Xiangwen , Wang Jintao 
Published: October 2022

Due to the emergence and wide spread of methicillin-resistant Staphylococcus aureus, the treatment of this kind of infection becomes more and more difficult. To solve the problem of drug resistance, it is urgent to develop new antibiotics to avoid the most serious situation of no drug available. Three new Ru complexes [Ru (dmob)2PMA] (PF6)2 (Ru-1) [Ru (bpy)2PMA] (PF6)2 (Ru-2) and [Ru (dmb)2PMA] (PF6)2 (Ru-3) (dmob = 4,4′-dimethoxy-2,2′-bipyridine, bpy = 2,2′-bipyridine, dmb = 4,4′-dimethyl-2,2′-bipyridine and PMA = N-(4-(1H-imidazo [4,5-f] [1,10] phenanthrolin-2-yl) -4-methyl-N-(p-tolyl) aniline) were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The detailed molecular structure of Ru-3 was determined by single crystal X-ray diffraction. Their antibacterial activities against Staphylococcus aureus (Staphylococcus aureus) were obvious and Ru-3 showed the best antibacterial effect with the minimum inhibitory concentration value of 4 μg ml−1. Therefore, further study on its biological activity showed that Ru-3 can effectively inhibit the formation of biofilm and destroy cell membrane. In vitro hemolysis test showed that Ru-3 has almost negligible cytotoxicity to mammalian red blood cells. In the toxicity test of wax moth insect model, Ru-3 exhibited low toxicity in vivo. These results, combined with histopathological studies, strongly suggest that Ru-3 was almost non-toxic. In addition, the synergistic effect of Ru-3 with common antibiotics such as ampicillin, chloramphenicol, tetracycline, kanamycin and gentamicin on Staphylococcus aureus was detected by chessboard method. Finally, in vivo results revealed that Ru-3 could obviously promote the wound healing of Staphylococcus aureus infected mice.
A novel approach based on the ultrasonic-assisted microwave method for the efficient synthesis of Sc-MOF@SiO2 core/shell nanostructures for H2S gas adsorption: A controllable systematic study for a green future
Authors: Muzammil Khursheed , Solanki Reena , Alkaim Ayad F. , Romero Parra Rosario Mireya , Lafta Holya A. , Jalil Abduladheem Turki , Gupta Reena , Hammid Ali Thaeer , Mustafa Yasser Fakri 
Published: October 2022

In this work, for the first time, novel Sc-MOF@SiO2 core/shell nanostructures have been synthesized under the optimal conditions of ultrasonic-assisted microwave routes. The final products showed small particle size distributions with homogeneous morphology (SEM results), high thermal stability (TG curve), high surface area (BET adsorption/desorption techniques), and significant porosity (BJH method). The final nanostructures of Sc-MOF@SiO2 core/shell with such distinct properties were used as a new compound for H2S adsorption. It was used with the systematic investigation based on a 2K−1 factorial design, which showed high-performance adsorption of about 5 mmol/g for these novel adsorbents; the optimal experimental conditions included pressure, 1.5 bar; contact time, 20 min; and temperature, 20°C. This study and its results promise a green future for the potential control of gas pollutants.
Periodontitis induced by Porphyromonas gingivalis drives impaired glucose metabolism in mice
Authors: Kang Ni , Zhang Yong , Xue Fei , Duan Jinyu , Chen Fan , Cai Yu , Luan Qingxian 
Published: October 2022

Periodontitis has been demonstrated to be bidirectionally associated with diabetes and has been recognized as a complication of diabetes. As a periodontal pathogen, Porphyromonas gingivalis is a possible pathogen linking periodontal disease and systemic diseases. It has also been found to be involved in the occurrence and development of diabetes. In this study, 6-week-old male C57BL/6 mice were orally administered the P. gingivalis strain ATCC381 for 22 weeks. Histological analysis of the gingival tissue and quantified analysis of alveolar bone loss were performed to evaluate periodontal destruction. Body weight, fasting glucose, glucose tolerance test (GTT), and insulin tolerance test (ITT) were used to evaluate glucose metabolism disorder. We then analyzed the expression profiles of inflammatory cytokines and chemokines in gingival tissue, the liver, and adipose tissue, as well as in serum. The results showed that mice in the P. gingivalis-administered group developed apparent gingival inflammation and more alveolar bone loss compared to the control group. After 22 weeks of P. gingivalis infection, significant differences were observed at 30 and 60 min for the GTT and at 15 min for the ITT. P. gingivalis-administered mice showed an increase in the mRNA expression levels of the pro-inflammatory cytokines (TNF-α, IL-6, IL-17, and IL-23) and chemokines (CCL2, CCL8, and CXCL10) in the gingiva and serum. The expression levels of the glucose metabolism-related genes were also changed in the liver and adipose tissue. Our results indicate that oral administration of P. gingivalis can induce changes in the inflammatory cytokines and chemokines in the gingiva and blood, can lead to alveolar bone loss and to inflammatory changes in the liver and adipose tissues, and can promote glucose metabolism disorder in mice.
The effect of topical airway anesthesia on hemodynamic profiles during the induction period in patients undergoing cardiac surgery: Study protocol for a randomized controlled trial
Authors: Du Wenya , Lv Meng , Chen Tingting , Sun Xiaxuan , Wang Jihua , Zhang Haixia , Wei Chuansong , Liu Yi , Qiao Changlong , Wang Yuelan 
Published: October 2022

BackgroundPatients scheduled for cardiac surgery are often accompanied by cardiac dysfunction and hemodynamic instability. However, the conventional induction strategy for anesthesia using high-dose intravenous anesthetics is often associated with persistent and recurrent hypotension after tracheal intubation. The purpose of this study is to investigate the effects of topical airway anesthesia on the hemodynamic profile of patients undergoing cardiac surgery during the induction period.MethodsThis is a superiority, single-blind, randomized controlled study with two parallel groups. Participants scheduled to undergo elective cardiac surgery will be allocated into two blocks according to the New York Heart Association (NYHA) classification and then randomly assigned to the following two groups at a 1:1 ratio: the conventional induction group and the combined topical airway anesthesia induction group. The combined topical airway anesthesia induction strategy includes aerosol inhalation airway anesthesia, subglottic airway anesthesia, and general anesthesia induction using low-dose intravenous anesthetics. The primary outcome is the area under the curve (AUC) of blood pressure below baseline mean arterial pressure (MAP) from 3 to 15 min after endotracheal intubation. Secondary outcomes include the AUC above baseline MAP and below baseline MAP at other time points, the highest and lowest arterial blood pressure values during the induction period, type and dose of vasoactive drugs, incidence of arrhythmias, cardiac function, and the incidence of postoperative hoarseness and sore throat.DiscussionThe study will explore whether aerosol inhalation airway anesthesia and subglottic airway anesthesia could reduce the incidence and duration of hypotension during the induction period in patients undergoing cardiac surgery.Clinical Trial RegistrationThis trial was registered on www.ClinicalTrials.gov (NCT05323786).
Combination of early Interleukin-6 and -18 levels predicts postoperative nosocomial infection
Authors: Yu Qingwei , Cen Chaoqun , Gao Min , Yuan Hong , Liu Jingjing 
Published: October 2022

BackgroundThe inflammatory response plays a critical role in postoperative nosocomial infections, which are the most common postoperative complications causing adverse events and poor postoperative outcomes. This study aimed to explore the ability of early inflammation-related factor levels to predict the occurrence of nosocomial infections after abdominal surgery.MethodsThe study included 146 patients with open abdominal surgery (a nosocomial infection group (NI group, n=42) and a no-nosocomial infection group (NNI group, n=104)). After 1:1 matching, the patients were divided into a matching nosocomial infection group (M-NI group, n=25) and a matching no-nosocomial infection group (M-NNI group, n=25). Serum levels of interleukin (IL)-6, IL-8, IL-10, IL-12, IL-18, macrophage migration inhibitory factor (MIF), and monocyte chemotactic protein (MCP-1) were tested at three time points (pre-operation, 0-hour post-operation (POD1) and 24-hour post-operation (POD2)). The area under the receiver operating characteristic curve (AUC-ROC) was used to test the predictive abilities.ResultsThere were significant differences in the levels of IL-6, IL-12, and IL-18 between the M-NI and M-NNI groups (p &lt; 0.05), but not in the levels of other inflammatory factors. MIF, IL-8, and MCP-1 levels were higher in the M-NI group than in the M-NNI group at POD2 (p &lt; 0.05). In the ROC analysis, the AUC for prediction of nosocomial infection using a combination of IL-6 and IL-18 at POD1 was 0.9616, while the AUCs for IL-6 alone and IL-12 alone were 0.8584 and 0.8256, respectively.ConclusionsThe combination of the levels of inflammatory factors, IL-6 and IL-18, at the 0-hour postoperative time point, significantly improved the predictive ability to the development of postoperative infection during perioperative period. Our study suggests the importance of monitoring postoperative inflammatory markers.
Effect of thyroid function on assisted reproduction outcomes in euthyroid infertile women: A single center retrospective data analysis and a systematic review and meta-analysis
Authors: d’Assunção Viviane Rosado Negreiros , Montagna Erik , d’Assunção Luis Eduardo Negreiros , Caldas Maria Madalena Pessoa , Christofolini Denise Maria , Barbosa Caio Parente , Negreiros Ricardo Andre Medeiros , Laganà Antonio Simone , Oliveira Renato de , Bianco Bianca 
Published: October 2022

BackgroundThe influence of thyroid-stimulating hormone (TSH) on gestational outcomes have been studied and checked whether differing TSH levels are relevant on human reproduction outcomes. International guidelines recommend TSH values &lt;2.5 mIU/L in women trying to conceive, since values above this level are related to a higher frequency of adverse reproductive outcomes. This study aimed to evaluate whether TSH values correlate with different gestational outcomes in euthyroid infertile women without autoimmune thyroid disease.MethodsA retrospective cohort study was conducted involving 256 women who underwent in vitro fertilization (IVF) treatment. The participants were divided into two groups: TSH 0.5-2.49 mIU/L (n=211) and TSH 2.5-4.5 mIU/L (n=45). The clinical data, hormonal profiles and reproductive outcomes were compared between groups. Additionally, a systematic review with meta-analysis following the PRISMA protocol was carried out in PubMed/MEDLINE, EMBASE, and SciELO, with no time or language restrictions, for articles comparing TSH groups named “low TSH” (&lt;2,5 mIU/L) and “high TSH” (≥2.5 mIU/L). A meta-analysis of proportions was performed with pooled estimates expressed as relative risk (RR) of events and a random effects model.ResultsAge, BMI, free thyroxine levels (FT4) hormonal profile and IVF outcomes were not different between groups, neither gestational outcomes (p=0.982). Also, no difference was observed when the TSH and FT4 levels were compared between patients with positive or negative gestational outcomes (p=0.27 and p=0.376). Regarding the systematic review with meta-analysis, 17 studies from 2006 to 2022 were included, and added by this original retrospective research comprising 13.247 women undergoing IVF. When comparing the proportions of clinical pregnancy between the TSH groups, no significant difference was found (RR 0.93, 95% CI 0.80–1.08), with high between studies heterogeneity (I²: 87%; τ2: 0.0544; p&lt;0.01). The number of deliveries was not significantly different between groups, despite a trend towards higher frequency in the high-TSH group (RR 0.96, 95% CI 0.90–1.02).ConclusionVariation in TSH levels within the normal range was not associated with pregnancy and delivery rates in women, without autoimmune thyroid disease, who underwent IVF treatment.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022306967.
Sustainable Energy Recovery From the Malaysian Coal Bottom Ash and the Effects of Fineness in Improving Concrete Properties
Authors: Beddu Salmia , Abd Manan Teh Sabariah Binti , Mohamed Nazri Fadzli , Kamal Nur Liyana Mohd , Mohamad Daud , Itam Zarina , Ahmad Mushtaq 
Published: October 2022

The particle size (µm) of coal bottom ash displayed significant effects on the concrete engineering properties. This research aims to assess the improvement of engineering properties of concrete containing CBA (fineness: 75 and 100 µm) known as Mix 75 and Mix 100, and to optimize the percentage of coal bottom ash as supplementary cement materials in concrete. The physicochemical properties of coal bottom ash were analyzed using X-ray fluorescence, X-ray diffraction, particle size distribution (PSD), and a scanning electron microscope. The strength of concrete was determined based on workability and compressive and splitting tensile strengths. The concrete strength improvement was optimized by response surface methodology. The results of the study showed that coal bottom ash was rich in silicates based on the highest peak at 45°. The scanning electron microscope images showed that coal bottom ash has few cenospheres and components of irregular-shaped char particles. The splitting tensile strengths in 28 curing days gradually decreased with an increase in coal bottom ash. The optimal percentage of coal bottom ash in Mix 75 is equivalent to 6% within 45.4 curing days producing 40 MPa of compressive strength. Meanwhile, the optimal percentage of CBA in Mix 100 is equivalent to 12% within 56 curing days producing 50 MPa of compressive strength. The future works needed to extend the experimental observations are the economic analysis and effect of the greenhouse reduction on the usage of CBA in building infrastructure.
Position of different nebulizer types for aerosol delivery in an adult model of mechanical ventilation
Authors: Hou Haijia , Xu Dongyang , Dai Bing , Zhao Hongwen , Wang Wei , Kang Jian , Tan Wei 
Published: October 2022

BackgroundThe optimal positions of different types of nebulizer for aerosol delivery remain unclear.MethodsThree ICU ventilators employing three types of nebulizer were separately connected to a simulated lung to simulate nebulization during invasive ventilation. Assist/control-pressure control (A/C-PC) mode was utilized, with inspiratory pressure (Pi) set to 12 cmH2O and positive end expiratory pressure (PEEP) set to 5 cmH2O, and with a target Vt of 500 ml. The bias flow of all the ventilators was set to 2 L/min. The three nebulizers were the continuous jet nebulizer (c-JN), the inspiratory synchronized jet nebulizer (i-JN), and the vibrating mesh nebulizer (VMN). The five nebulizer positions were as follows: at the Y-piece (position 1) and 15 cm from the Y-piece (position 2) between the endotracheal tube and the Y-piece, at the Y-piece (position 3) and 15 cm from the Y-piece (position 4) in the inspiratory limb; and at the humidifier inlet (position 5). Aerosols were collected with a disposable filter placed at the simulated lung outlet (n = 3) and were measured by UV spectrophotometry (276 nm). The measurements were compared under different experimental conditions.ResultsThe aerosol delivery of c-JN, i-JN, and VMN was 5.33 ± 0.49~11.12 ± 0.36%, 7.73 ± 0.76~13.75 ± 0.46% and 11.13 ± 56–30.2 ± 1.63%, respectively. The higher aerosol delivery: for c-JN~Positions 2 (10.95 ± 0.15%), fori-JN~Positions 1 or 2 (12.91 ± 0.88% or 13.45 ± 0.42%), for VMN~Positions 4(29.03 ± 1.08%); the lower aerosol delivery: for c-JN~Positions 1, 3 or 5, fori-JN~Positions 4 or 5, for VMN~Positions 5.The highest aerosol delivery:For c-JN at Position 2 (10.95 ± .15%), for i-JN at Position 1 or 2 (12.91 ± .88% or 13.45 ± .42%), for VMN at Positions 4 (29. 03 ± 1.08%); the lower aerosol delivery: for c-JN at Positions 1, 3 or 5, for i-JN at Positions 4 or 5, for VMN at Positions 5. The highest aerosol deliveryof c-JN was lower than that of i-JN while the VMN was the highest (all P &lt; .05). However, no differences were observed between the highest aerosol delivery with c-JN and the lowest aerosol delivery with i-JN. Similar results were found between the lowest aerosol delivery with VMN and the highest aerosol delivery with c-JN /i-JN in the Avea ventilator. There were no differences in the highest aerosol delivery of each nebulizer among the different ventilators (all p &gt; 0.05).ConclusionDuring adult mechanical ventilation, the type and position of nebulizer influences aerosol delivery efficiency, with no differences between ventilators.