bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hereditary angioedema in children and adolescents
Authors: Mansour Eli , Veronez Camila L. , Craig Timothy , Grumach Anete Sevciovic 
Published: April 2022

Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Family history can help with the diagnosis; however, approximately 25% of the cases are de novo mutations. Biochemical diagnosis should be delayed until after 1 year of age. Children were often excluded from advances in therapy for hereditary angioedema since most of the new medicines were tested in adults and thus excluded by the Food and Drug Administration (FDA) and other agencies for approval to be used in children. Treatment of attacks is available for the pediatric patient; however, barriers still exist for the use of long-term prophylaxis in young children.
HIV Stigma Scale: Translation and Validation of the Short Version to the Portuguese Population
Authors: Gonçalves Mariana , Morgado Diogo , Castro Bárbara , Maia Ângela 
Published: April 2022

The objective was to translate, adapt, and analyze the psychometric properties of a shortened version of the HIV Stigma Scale using a sample of 100 HIV+ adults, with a mean age of 49.88 (SD = 12.03) diagnosed for an average of 9.39 (SD = 7.36) years. The psychometric properties of the short version of the Stigma Scale were analyzed through the one-factor structure and the original four-factor structure, showing good fit for this last model. Convergent validity was found to be close to the acceptable for the factors, “concerns about public attitudes” and “negative self-image”, and good for the factors, “disclosure concerns” and “personalized stigma”. The results showed adequate discriminant validity for all factors, coefficient Omega was above .70 for the four factors, showing adequate reliability. This Portuguese version of the Stigma Scale is a good measure to assess the stigma of people living with HIV.
Design, synthesis and anticancer activity studies of some novel 1,2,4 triazole pyridine derivatives
Authors: Chakraborty Anup K , Patel Namrata , Karole Sarita , Loksh Kavita R. 
Published: April 2022

The development of new anticancer agents is one of the most pressing research areas in medicinal chemistry and medicine. The importance of triazole and pyridine rings as scaffolds present in a wide range of therapeutic agents has been well reported and has driven the synthesis of a large number of novel anticancer agents. The presence of these heterocyclic furnishes extensive synthetic possibilities due to the presence of several reaction sites. Prompted by these data we designed, synthesized and evaluated a series of novel 1, 2, 4-triazole-pyridine hybrid derivatives as potential anticancer agents. To design and synthesize series of novel 1, 2, 4-triazole-pyridine hybrid derivatives as potential anticancer agents Derivatives were synthesized by the reaction of nicotinohydrazide with carbon disulfide to yield potassium-3-pyridyl-dithiocarbazate (I). This was further cyclized with ammonia solution to yield 5-mercapto-substituted 1, 2, 4-triazole-pyridine hybrid (II). This was finally reacted with different substituted benzyl derivatives to produce 1, 2, 4-triazole-pyridine hybrid derivatives (III). The purity of the derivatives was confirmed by thin-layer chromatography and melting point. Structure of these derivatives was set up by determining its infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectroscopy. Further, the synthesized 1, 2, 4 triazole pyridine derivatives were tested for their in vitro anticancer activities against murine melanoma (B16F10) using the MTT reduction assay method. The cell viability study of synthesized compounds concludes that all compounds have moderate to potent anticancer activities against cancer cell lines. Compounds TP1-TP7 have IC in the range of 41.12μM to 61.11μM and the highest activity was observed for compound TP6 against murine melanoma (B16F10) cell line.Thepresent research may pave a way for the development of 1, 2, 4-triazole-pyridine as novel anticancer agents with good efficacy and lesser adverse effects.
Review of the Factors Affecting Dichotic Listening
Authors: Majidpour Amir , Moheb Aleaba Mahshid , Aghamolaei Maryam , Nazeri Ahmadreza 
Published: April 2022

Background and Aim: Dichotic listening (DL) test is a non-invasive method used to study hemispheric asymmetry, hemispheric dominance for language processing, or brain lateralization. In addition to the type, concurrence, and the intensity of stimuli presented to the ears, other factors exist that may have less effect on the DL test results. This review study aims to find these factors.
Recent Findings: The factors that affects the DL included ear advantage, attention, working memory, gender, and top-down and bottom-up factors. These factors were reviewed and discussed in detail so that more precise test results can be obtained. Moreover, due to the significant effects of each factor on the test results, manipulation of these factors was also reviewed.
Conclusion: According to the results of previous studies, ear advantage, attention, working memory, gender, and top-down and bottom-up factors play an important role in the interpretation of DL results; their negligence during the test can affect the outcomes and provide incorrect brain lateralization results.
Keywords: Dichotic listening; ear advantage; top-down; bottom-up; working memory; attention
Consonant Production Skills in Children with Cochlear Implants and Normal-Hearing Children Aged 3–5 Years
Authors: Sohrabi Mitra , Jalilevand Nahid 
Published: April 2022

Background and Aim: Consonant development plays a significant role in speech intelligibility which is impaired in children with profound hearing loss. Cochlear implant (CI) can facilitate the development of language comprehension and sound production in children with severe to profound sensorineural hearing loss. This study aimed to compare consonant production skills in children with CI and normal-hearing (NH) children aged 3–5 years.
Methods: In this cross-sectional study, participants were 20 children with CI and 20 age- matched NH children. The consonant production skills were assessed using the speech intelligibility test in Persian.
Results: There were significant differences between CI and NH children (p<0.05), where the highest percentage of correct production in both groups was related to the manner of articulation of stop and nasal consonants. NH children showed less accuracy only in /r/ and /ʧ/, while children with CI were less accurate in /q/, /x/, /ʤ/, /l/, /j/, and /r/.
Conclusion: Children with CI have lower scores compared to age-matched NH peers, but they have similar consonant production skills.
Keywords: Cochlear implant; consonant production; consonant accuracy
Evaluation of the Possible Effect of the Influenza Vaccine on the Severity, Mortality, and Length of Hospitalization among Unvaccinated COVID-19 Patients; An Observational, Cross-Sectional Study
Authors: Alizadeh Nafiseh , Tabatabaei Fatemeh Sadat , Borran Mina , Dianatkhah Mehrnoush , Azimi Amirali , Forghani Seyedeh Nafise , Akbarpour Samaneh , Alizadeh Mahboubeh , Torabi Sara , Faraji Neda 
Published: April 2022

Background: Based upon WHO (World Health Organization) Coronavirus Dashboard more than 5 million deaths worldwide have been attributed to the COVID-19 (Coronavirus Disease 2019) caused by the SARS-Cov-2 virus (Severe Acute Respiratory Syndrome Coronavirus) till November 2021. The annual flu vaccination has raised many questions about the vaccine's effects on Covid-19 outcomes. Several possible mechanisms including cross-reactivity and cross-protection have been reported to be responsible for the potential protective effect of the flu vaccine on the COVID-19 infection. This study was performed to evaluate the possible effect of the influenza vaccine on the disease severity, the mortality rate, and the length of hospitalization in COVID-19 patients.
Methods: The data of 1300 patients were recorded from May 2020 to October 2020. Patients with a previous history of COVID-19, patients under 18 years old, and patients who did not have accurate information about their influenza vaccination history were excluded. 498 hospitalized unvaccinated COVID-19 patients with typical clinical manifestations and a positive PCR (Polymerase Chain Reaction) test for COVID-19 were included in this observational, cross-sectional study. The participants were divided into two groups (vaccinated and unvaccinated) based on the history of influenza vaccination at the time of admission.
Results: The length of hospital stay was lower in the vaccinated compared to the unvaccinated group (p < 0.05). However, there was no significant difference between the mortality rate, the need for ICU (Intensive Care Unit) admission, and the severity of the disease between the two groups (p> 0.05).
Conclusion: Since the patients studied in this article did not receive any of the Covid-19 vaccines; Therefore, the effect of influenza vaccination on the clinical course of Covid-19 can be evaluated using the results of this study. A longer length of hospital stay was observed in the unvaccinated patients in our study, which may suggest the possible protective effect of the influenza vaccine against COVID-19.
How secondary students develop the meaning of fractions? A hermeneutic phenomenological study
Authors: Isnawan Muhamad Galang , Suryadi Didi , Turmudi Turmudi 
Published: April 2022

[English]: Understanding various meanings of fractions is a foundation to learn related fractions topics. However, students are struggling with this essential topic. This hermeneutic phenomenological study aims to further investigate the meaning of fractions developed by secondary school students, the process of constructing the meaning using models, and factors that hinder the development of the meaning. It involved twenty-two students given fractions tasks, and some students of the different categories of mathematics ability were selected to be interviewed. A thematic analysis using NVivo-12 found that some students interpret fractions as a tool and integers. Most of the students in all categories tend to espouse fractions as ratio and quotient. However, they cannot use the models to represent the meanings. This study reveals that the students’ developed meanings of fractions are limited and different from what primary students have. In addition, there is an inconsistency between the espoused meanings and the use of models. The limitation and inconsistency are considered to be affected by teachers’ lack of content knowledge on the topic and less attention to using models in teaching fractions. This study implies that (mathematics) teachers education should pay more attention to the meaning of fractions and their related models in learning.
[Bahasa]: Memahami makna pecahan merupakan dasar untuk mempelajari topik-topik terkait pecahan. Namun, siswa masih mengalami kesulitan dalam topik penting ini. Penelitian fenomenologi hermeneutika ini bertujuan untuk mengkaji lebih lanjut makna pecahan yang dibangun oleh siswa sekolah menengah, proses mengkonstruksi makna menggunakan berbagai model, dan faktor-faktor yang menghambat pengembangan makna pecahan. Penelitian ini melibatkan dua puluh dua siswa yang diberikan tugas matematika dan beberapa siswa dari berbagai kategori kemampuan matematika dipilih untuk diwawancarai. Analisis tematik menggunakan NVivo-12 menemukan bahwa beberapa siswa memaknai pecahan sebagai alat bantu dan bilangan bulat. Sebagian besar siswa pada semua kategori kemampuan matematika cenderung memaknai pecahan sebagai rasio dan hasil bagi. Namun, mereka tidak bisa menggunakan model untuk merepresentasikan makna pecahan tersebut. Penelitian ini menunjukkan bahwa makna pecahan yang dimiliki oleh siswa terbatas dan berbeda dari makna pecahan yang dimiliki siswa sekolah dasar. Selain itu, terdapat inkonsistensi antara makna pecahan yang diungkap siswa dengan penggunaan model. Keterbatasan dan inkonsistensi tersebut dianggap dipengaruhi oleh kurangnya pengetahuan konten guru tentang materi dan kurangnya penggunaan model dalam mengajar pecahan. Dalam hal ini, pendidikan guru (matematika) harus lebih memperhatikan makna pecahan dan penggunaan model pecahan dalam pembelajaran.
ESTIMASI NILAI CADANGAN KARBON MENGGUNAKAN ANALISIS NDVI (NORMALIZED DIFFERENCE VEGETATION INDEX) DI KHDTK UNIVERSITAS LAMBUNG MANGKURAT
Authors: Karmila Dea , Jauhari Ahmad , Kanti Rina 
Published: April 2022

This research aims to determine the value of carbon stock based on the NDVI and make a connection between the value of NDVI and the value of carbon stock. This research was conducted at KHDTK Lambung Mangkurat University, South Borneo. The time needed to carry out this research for four months, from january to April, which includes research preparation, data collection and preparation of research reports. Estimation of carbon stock calculated from 47% of biomass value with trees >10 cm in diameter on three types of vegetation density. Vegetation density was predicted using the NDVI value processed using QGIS software and based on field observations. The value of NDVI at very rare densities with the range of value (0.52-0.59),at rare densities with the range of value (0.69-0.77), and at medium densities with the range of value (0.81-0.85). The value of carbon stock in three types of vegetation density each are 3.34 (ton/ha) at very rare densities, 11.61 (ton/ha) at rare densities to medium, and 32.04 (ton/ha) at medium densities. The relationship between the value of NDVI and the value of carbon stock uses the exponential regression equation model y = 0.0304e8.2416x and determination coefficient R2=0.909. determination coefficient R2>0.40 show strong relationships, thus the greater the value of R2 between NDVI and stock carbon are better.
HUBUNGAN ANTARA UKURAN RUMPANG DAN PERTUMBUHAN DIAMETER TANAMAN ULIN (Eusideroxylon zwageri Teijsm & Binn.) DI KHDTK KINTAP KECAMATAN KINTAP KALIMANTAN SELATAN
Authors: Wardani Susi , Basir Basir , Bakri Sulaiman 
Published: April 2022

Deforestation and degradation of natural forests and plants reached 1.6-2.0 million ha. Forestry Research and Development Agencies throughout Indonesia have begun to develop various silvicultural techniques of ulin so that the extinction of the plant can be prevented. One of the silvicultural systems that began to be developed was a gap system. The purpose of this study was to determine the growth of ulin (Eusideroxylon zwageri Teijsm & Binn.), and the influence of the size of the gaps on the growth of ulin plants in Kintap KHDTK. The results obtained were the average growth of the lowest ironwood plants from the value of diameter (1.27 cm) that was at without gap treatment, while the highest growth was the best diameter (5.01 cm), which was at the gap with diameter of 12 m. The optimal diameter of ironwood growth is in the size of a 12 m. Treatment of overlays of 12 m gives a good growth effect for ironwod plants.
PENGARUH PENAMBAHAN SERBUK GAHARU (Aquilaria malaccensis) TERHADAP KARAKTERISTIK BRIKET ARANG AROMATERAPI DARI LIMBAH ARANG SERBUK KAYU CAMPURAN
Authors: Saputra Eky , Violet Violet , Sari Noor Mirad 
Published: April 2022

This studygaims to analyze the characteristics of aromatherapy charcoal briquettes from mixed wood charcoal powder waste and agarwood wood carried out organoleptic tests in the form of the old ability to burn briquettes to ash when aromatherapy charcoal spreads in a room. The results of the study showed that of the highest charcoal briquette density average value was (0.90 gr/cm3) and the lowest (0.82 gr/cm3), highest moisture content value of (9.33%) and the lowest of (8.46%). Value of flying substances levels (47.9%) and the lowest is (40.66%). Value of the highest ash content characteristics of (40.37%) and the lowest (33.28%). Testing the highest average value of bonded carbon characteristics is 28.82% and the lowest is (9.305%). Value of the highest heating characteristics (4174,696 cal/gr) and the lowest (3784,976 cal/gr). From all the results of the testing of the characteristics of the aromatherapy charcoal briquettes from the mixture of wood charcoal powder and agarwood powder waste on average do not meet ASTM testing standards. The organoleptic test of mold without holes that most quickly consumes aromatherapy at a concentration of 6 grams with 5 minutes and the longest smell of aromatherapy is 12, 18, and 24 grams with 7 minutes with an average of 46 minutes. And organoleptic test with the fastest hollow molds smelled at concentrations of 12 grams, 18 grams, 24 grams at 15 seconds, and on average each concentration had a scent that runs out at 7 minutes with an average of 55 minutes long liters of briquettes.Keywords : Characteristics of Charcoal Briquettes; Organoleptic Test; Mixed Wood Charcoal Waste and Agarwood
KARAKTERISTIKkPOHON TEMPAT TIDUR (night sleeping trees) BEKANTAN (Nasalis larvatus) DI TAMAN WISATA ALAM PULAU BAKUT KABUPATEN BARITO KUALA PROVINSI KALIMANTAN SELATAN
Authors: Lisnaini Lisnaini , Fithria Abdi , Rudy Gusti Syeransyah 
Published: April 2022

This research was conducted on July 2018 in Pulau Bakut Natural Park, Barito Kuala district, South Kalimantan province. Primates spend more time in sleeping sites, sleeping sites selection can affect their survival. The variables observed in this study were 6 types, namely tree species, tree height and diameter, tree distance from river bank, number of main branches, tree distance from feed sources and number of sleeping trees. Trees used as sleeping trees by proboscis monkeys did not depend on tree species. Sleeping trees were on the edge of the island between 0-15 m from the river. The selected sleeping trees of proboscis monkeys had relatively large stems (between 23.57 to 92.36 cm) and were relatively high (10—35 m) with many branches, overlapped each other, thus created connectivity with the surrounding vegetation. The sleeping trees of proboscis monkeys identified during the study period were 2 (two) species, namely Sonneratia caseolaris (sea rambai/red pidada) and Fagraea crenulata (moon wood). The selection of sleeping trees on the river bank was a proboscis monkey's strategy to avoid predators, avoid parasites from their feces, reduce injuries due to falls, facilitate social interaction and motion efficiencyKeywords: Proboscis monkeys; Nasalis larvatus; night sleeping trees; bakut island
PRODUKTIVITAS DAN RENDEMEN CUKA KAYU DAN ARANG MANGIUM (Acacia mangium) DI KELOMPOK TANI HUTAN ALIMPUNG DESA TIWINGAN LAMA
Authors: Pratiwi Setiani Rahma , Lusyiani Lusyiani , Satriadi Trisnu 
Published: April 2022

This study aimed to analyze the productivity and yield of Mangium Wood Vinegar and Charcoal in the Forest Farmer Group Alimpung in Tiwingan Lama Village. The method used to determine productivity is to calculate the amount of raw materials and total time. The yield is measured by counting the amount of raw material and wood vinegar or charcoal produced. The results showed that the average productivity of acacia wood vinegar was 0.037 kg / hour and acacia wood charcoal was 0.230 kg / hour. The processing process produces a yield 7.500% wood vinegar and 46.089% wood charcoal. The productivity of processing mangium wood into wood vinegar and charcoal is 0.267 kg / hour and the yield is 53.589%. Waste generated from the manufacture of wood vinegar and charcoal amounted to 46.411%. Productivity and yield are influenced by tools, raw materials and workers. Keywords: Productivity; yield; wood vinegar; charcoal; mangium
PENGARUH PEMBERIAN BERBAGAI TINGKATAN KOMBINASI PERLAKUAN NAUNGAN TERHADAP PERTUMBUHAN ANAKAN KEMIRI (Aleurites moluccana L.Willd)
Authors: Prilia Dewi Desti Nanda , Basir Ahmad , Pujawati Eny Dwi 
Published: April 2022

This research aims to calculate life percentage on every treatment and analyze the growth of Kemiri (Aleurites moluccana L. Willd) seedlings to the various interaction between shade or light intensity. The variable of seedling growth includes height, diameter and sum of leaves. This research was conducted in open land area around farms and plantations with flat slope conditions in Padang Anyar roads, Tungkaran, RT 04, RW 02, South Borneo Province for 3 month. The data was analized using factorial Completely Randomized Design (CRD) with 4 treatment. Each replication consists of five sample and every treatment was repeated trhree times so that 60 seeds are needed (4x5x3). The result showed the life percentage of seedlings on every treatment was 100%. Growth under shade shows a significant effect on height of seedling, a very significant effect on diameter of seedling, and not give significant effect for sum leaves, known that 50% shade the best give effect to average response toward the increase of tall was 43,73 cm, stem diameter was 0,73 cm and sum of leaves was 13,8 leaves). Keywords: Growth; Kemiri; Shade
SIFAT FISIK DAN MEKANIK PAPAN PARTIKEL DARI SERBUK GERGAJIAN KAYU SENGON LAUT (Paraserianthes falcataria) MENGGUNAKAN PEREKAT PVAC
Authors: Mirza Hendra , Mahdie Muhammad Faisal , Thamrin Gusti Ahmad Rahmat 
Published: April 2022

The purpose of this study is to analyze the physical and mechanical properties of the particle board of sengon wood powder (Paraserianthes falcataria) using PVAC adhesives and to analyze the suitability of wood as raw material for particle board. The method used is physical properties testing in the form of testing water content and density as well as testing mechanical properties in the form of flexural strength (MoE) and fracture firmness (MoR). The physical properties of the particle board with the addition of different adhesives between 1.0.54-1.0.63 grams each treatment did not significantly affect the value of water content. Overall average water content reaches less than 14% that has met SNI, each treatment has no significant effect on the density value, the density value meets the Indonesian National Standard (SNI) with SNI requirements for particle board density of 0.4-0.9 gr / cm3 (low density), the average modulus of elasticity (MoE) produced had a very significant effect and fulfilled the SNI for particle board min 20400 kgf / cm2 in A2 treatment, but did not meet the standards in A1 and A3 treatments, the average value of fracture constancy (MoR) for each treatment has a very significant effect and according to the standards set SNI min 82 kgf / cm2 already meets the standard in A2 treatment with a ratio between powder and adhesive 1: 0.58 while it does not meet the standard in treatment A1 , and A3. The suitability of Sengon wood powder (Paraserianthes falcataria) to the physical and mechanical properties of the particle board in the form of water content, density, flexural strength (MoE) and fracture firmness (MoR) for each given treatment is appropriate because most have met the Standard Indonesian National (SNI).Keywords: Particle Board, Physical Properties, Mechanical Properties