bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-Only Radiotherapy: An Exploratory Study for Automatic Dose Prediction on Rectal Cancer Patients Via Deep Adversarial Network
Authors: Cui Jiaqi , Jiao Zhengyang , Wei Zhigong , Hu Xiaolin , Wang Yan , Xiao Jianghong , Peng Xingchen 
Published: July 2022

PurposeCurrent deep learning methods for dose prediction require manual delineations of planning target volume (PTV) and organs at risk (OARs) besides the original CT images. Perceiving the time cost of manual contour delineation, we expect to explore the feasibility of accelerating the radiotherapy planning by leveraging only the CT images to produce high-quality dose distribution maps while generating the contour information automatically.Materials and MethodsWe developed a generative adversarial network (GAN) with multi-task learning (MTL) strategy to produce accurate dose distribution maps without manually delineated contours. To balance the relative importance of each task (i.e., the primary dose prediction task and the auxiliary tumor segmentation task), a multi-task loss function was employed. Our model was trained, validated and evaluated on a cohort of 130 rectal cancer patients.ResultsExperimental results manifest the feasibility and improvements of our contour-free method. Compared to other mainstream methods (i.e., U-net, DeepLabV3+, DoseNet, and GAN), the proposed method produces the leading performance with statistically significant improvements by achieving the highest HI of 1.023 (3.27E-5) and the lowest prediction error with ΔD95 of 0.125 (0.035) and ΔDmean of 0.023 (4.19E-4), respectively. The DVH differences between the predicted dose and the ideal dose are subtle and the errors in the difference maps are minimal. In addition, we conducted the ablation study to validate the effectiveness of each module. Furthermore, the results of attention maps also prove that our CT-only prediction model is capable of paying attention to both the target tumor (i.e., high dose distribution area) and the surrounding healthy tissues (i.e., low dose distribution areas).ConclusionThe proposed CT-only dose prediction framework is capable of producing acceptable dose maps and reducing the time and labor for manual delineation, thus having great clinical potential in providing accurate and accelerated radiotherapy. Code is available at https://github.com/joegit-code/DoseWithCT
Trends in Oropharyngeal Cancer Incidence Among Adult Men and Women in the United States From 2001 to 2018
Authors: Guo Fangjian , Chang Mihyun , Scholl Matthew , McKinnon Brian , Berenson Abbey B. 
Published: July 2022

BackgroundThe human papillomavirus (HPV) vaccine was approved in 2006 and has been shown to decrease vaccine-related HPV types in the oropharynx. Its impact on the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) has not been examined. We investigated the impact of HPV vaccination on the incidence of HPV-related OPSCC in the US among male and female adults from different age groups.MethodsThe US Cancer Statistics 2001–2018 database and the National Cancer Institute (NCI)’s Surveillance Epidemiology and End Results (SEER) program were used in this study. OPSCC incidence was age-adjusted to the US standard population in 2000. Cause-specific 5-year survival probability was calculated using 60 monthly intervals in SEER*Stat software.ResultsIncidence of HPV-related OPSCC was much higher in males than in females. Age-adjusted annual incidence of OPSCC was significantly lower in 2014-2018 than in 2002-2006 among males 20-44 years old (11.4 vs 12.8 per 1,000,000, rate ratio 0.89, 95% confidence interval 0.84-0.93) and among females 20-44 years old (3.0 vs 3.6 per 1,000,000, rate ratio 0.86, 95% confidence interval 0.78-0.95), but increased in both 45-64 year old and 65+ year old males and females. Joinpoint regression revealed a significant joint in the HPV-OPSCC incidence trend for 20-44-year-old males in 2008 at which time the incidence began to decrease. Except for 20-44 year old females (74.8% in 2002-2006 vs. 75.7% in 2009-2013, p=0.84), cancer-specific 5-year survivals significantly improved for males and females of all age groups.ConclusionsHPV-related OPSCC was much more common in males. Incidence of HPV-related OPSCC declined among young adults during the vaccination era compared with pre-vaccination era. Cancer-specific 5-year survival was significantly improved in young males but not in young females.
Exhaled Aerosols in SARS-CoV-2 Polymerase Chain Reaction-Positive Children and Age-Matched-Negative Controls
Authors: Gutmann Desiree , Donath Helena , Herrlich Laura , Lehmkühler Timon , Landeis Anton , Ume Emily R. , Hutter Martin , Goßmann Ann-Kathrin , Weis Frederik , Weiß Maximilian , Rabenau Holger F. , Zielen Stefan 
Published: July 2022

BackgroundChildren and adolescents seem to be less affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease in terms of severity, especially until the increasing spread of the omicron variant in December 2021. Anatomical structures and lower number of exhaled aerosols may in part explain this phenomenon. In a cohort of healthy and SARS-CoV-2 infected children, we compared exhaled particle counts to gain further insights about the spreading of SARS-CoV-2.Materials and MethodsIn this single-center prospective observational trial, a total of 162 children and adolescents (age 6–17 years), of whom 39 were polymerase chain reaction (PCR)-positive for SARS-CoV-2 and 123 PCR-negative, were included. The 39 PCR-positive children were compared to 39 PCR-negative age-matched controls. The data of all PCR-negative children were analyzed to determine baseline exhaled particle counts in children. In addition, medical and clinical history was obtained and spirometry was measured.ResultsBaseline exhaled particle counts were low in healthy children. Exhaled particle counts were significantly increased in SARS-CoV-2 PCR-positive children (median 355.0/L; range 81–6955/L), compared to age-matched -negative children (median 157.0/L; range 1–533/L; p &lt; 0.001).ConclusionSARS-CoV-2 PCR-positive children exhaled significantly higher levels of aerosols than healthy children. Overall children had low levels of exhaled particle counts, possibly indicating that children are not the major driver of the SARS-CoV-2 pandemic.Trial Registration[ClinicalTrials.gov], Identifier [NCT04739020].
Increasing Trends of Polypharmacy and Potentially Inappropriate Medication Use in Older Lung Cancer Patients in China: A Repeated Cross-Sectional Study
Authors: Tian Fangyuan , Chen Zhaoyan , Chen Xi , Zhao Mengnan 
Published: July 2022

Objectives: Polypharmacy and potentially inappropriate medication (PIM) use are frequent in older lung cancer patients. This study aimed to examine the trends of polypharmacy and PIM use and explore risk factors for PIM use based on the 2019 Beers criteria in older Chinese lung cancer outpatients with multimorbidity.Methods: A repeated cross-sectional study was conducted using electronic medical data consisting of the prescriptions of older lung cancer outpatients in China from January 2016 to December 2018. Polypharmacy was defined as the use of five or more medications. The 2019 Beers criteria were used to evaluate the PIM use of older cancer outpatients (age ≥65 years), and multivariate logistic regression was used to identify the risk factors for PIM use.Results: A total of 3,286 older lung cancer outpatients and their prescriptions were included in the study. The prevalence of polypharmacy was 14.27% in 2016, 16.55% in 2017, and 18.04% in 2018. The prevalence of PIM use, according to the 2019 Beers criteria, was 31.94% in 2016, 35.78% in 2017, and 42.67% in 2018. The two most frequently used PIMs in older lung cancer outpatients were estazolam and tramadol. The logistic regression demonstrated that age 75 to 79, polypharmacy, irrational use of drugs, and lung cancer accompanied by sleep disorders, anxiety or depression, or pain were positively associated with PIM use in older lung cancer outpatients.Conclusion: The prevalence of polypharmacy and PIM use in older lung cancer outpatients with multimorbidity was high in China, and polypharmacy and PIM use increased over time. Further research on interventions rationing PIM use in the older lung cancer patient population is needed.
Major areas of interest of artificial intelligence research applied to health care administrative data: a scoping review
Authors: Bukhtiyarova Olga , Abderrazak Amna , Chiu Yohann , Sparano Stephanie , Simard Marc , Sirois Caroline 
Published: July 2022

Introduction: The ongoing collection of large medical data has created conditions for application of artificial intelligence (AI) in research. This scoping review aimed to identify major areas of interest of AI applied to health care administrative data.Methods: The search was performed in seven databases: Medline, Embase, CINAHL, Web of science, IEEE, ICM digital library, and Compendex. We included articles published between January 2001 and March 2021, that described research with AI applied to medical diagnostics, pharmacotherapy, and health outcomes data. We screened the full text content and used natural language processing to automatically extract health areas of interest, principal AI methods, and names of medications.Results: Out of 14,864 articles, 343 were included. We determined ten areas of interest, the most common being health diagnostic or treatment outcome prediction (32%); representation of medical data, clinical pathways, and data temporality (i.e., transformation of raw medical data into compact and analysis-friendly format) (22%); and adverse drug effects, drug-drug interactions, and medication cascades (15%). Less attention has been devoted to areas such as health effects of polypharmacy (1%); and reinforcement learning (1%). The most common AI methods were decision trees, cluster analysis, random forests, and support vector machines. Most frequently mentioned medications included insulin, metformin, vitamins, acetaminophen, and heparin.Conclusions: The scoping review revealed the potential of AI application to health-related studies. However, several areas of interest in pharmacoepidemiology are sparsely reported, and the lack of details in studies related to pharmacotherapy suggests that AI could be used more optimally in pharmacoepidemiologic research.
What is the physiological impact of reducing the 2,000 m Olympic distance in rowing to 1,500 m and 1,000 m for French young competitive rowers? Insights from the energy system contribution
Authors: Diry Allison , Ratel Sébastien , Nevill Alan , Maciejewski Hugo 
Published: July 2022

French rowing federation reduced the competition distance to 1,500 and 1,000 m in rowers under 16- (U16) and 14-year-old (U14) respectively, to prepare them progressively to the Olympic 2,000 m distance in under 18-year-old (U18). This study aimed to check the hypothesis that relative aerobic (%EAe) and anaerobic (%EAn) energy contributions would be comparable between the competition distances since the more oxidative profile of younger age categories could offset the greater anaerobic contribution induced by shorter rowing races. Thirty-one 12- to 17-year-old competitive rowers performed a race of 2,000, 1,500, or 1,000 m on a rowing ergometer according to their age category. %EAe and %EAn were estimated from oxygen consumption, changes in blood lactate concentration and their energy equivalents. %EAe was lower in U16 than U18 (84.7 vs. 87.0%, p &lt; 0.01), and in U14 than U16 (80.6 vs. 84.7%, p &lt; 0.001). %EAn was higher in U16 than U18 (15.3 vs. 13.0%, p &lt; 0.01), and in U14 than U16 (19.4 vs. 15.3%, p &lt; 0.01). The results did not confirm our initial hypothesis since %EAe and %EAn were significantly different between the race distances, and thus age categories. However, %EAn in U18, U16 and U14 were found to be in the range of values previously found in adult rowers over the 2,000 m Olympic distance (12–30%). Therefore, on a practical level, the strategy implemented by the French rowing federation to reduce the competition distance in the younger age categories could be relevant to progressively prepare them to the physiological requirements encountered over the Olympic distance.
Immunization of Broiler Chickens With a Killed Chitosan Nanoparticle Salmonella Vaccine Decreases Salmonella Enterica Serovar Enteritidis Load
Authors: Acevedo-Villanueva Keila , Akerele Gabriel , Al-Hakeem Walid , Adams Daniel , Gourapura Renukaradhy , Selvaraj Ramesh 
Published: July 2022

There is a critical need for an oral-killed Salmonella vaccine for broilers. Chitosan nanoparticle (CNP) vaccines can be used to deliver Salmonella antigens orally. We investigated the efficacy of a killed Salmonella CNP vaccine on broilers. CNP vaccine was synthesized using Salmonella enterica serovar Enteritidis (S. Enteritidis) outer membrane and flagella proteins. CNP was stable at acidic conditions by releasing 14% of proteins at pH 5.5. At 17 h post-incubation, the cumulative protein release for CNP was 75% at pH 7.4. Two hundred microliters of PBS with chicken red blood cells incubated with 20 μg/ml CNP released 0% hemoglobin. Three hundred chicks were allocated into 1) Control, 2) Challenge, 3) Vaccine + Challenge. At d1 of age, chicks were spray-vaccinated with PBS or 40 mg CNP. At d7 of age, chicks were orally-vaccinated with PBS or 20 μg CNP/bird. At d14 of age, birds were orally-challenged with PBS or 1 × 107 CFU/bird of S. Enteritidis. The CNP-vaccinated birds had higher antigen-specific IgY/IgA and lymphocyte-proliferation against flagellin (p &lt; 0.05). At 14 days post-infection, CNP-vaccinated birds reversed the loss in gut permeability by 13% (p &lt; 0.05). At 21 days post-infection, the CNP-vaccinated birds decreased S. Enteritidis in the ceca and spleen by 2 Log10 CFU/g, and in the small intestine by 0.6 Log10 CFU/g (p &lt; 0.05). We conclude that the CNP vaccine is a viable alternative to conventional Salmonella poultry vaccines.
Grief experience among ICU staff with loss of family members during COVID-19 outbreak in IRAN: A qualitative study
Authors: Nohesara Shabnam , Saeidi Mahdieh , Mosavari Hesam , Ghalichi Leila , Alebouyeh Mahmoud Reza 
Published: July 2022

IntroductionThe COVID-19 crisis created a lot of problems in people's lives. Different lifestyles, mental health, communication, rituals and traditions, particularly those involved in mourning, have changed drastically. Medical staff faced numerous critically ill patients every day. This greatly distressed the staff, especially the ICU staff. The end result was considerable amounts of mental distress for the medical staff who lost family members to COVID-19 making the distress even more complex.MethodsWe carried out this qualitative research to study the grief experiences of 12 Iranian ICU staff members at the Rasoul Akram Hospital who had experienced the loss of a family member to the COVID-19 pandemic. We studied the effects of how their own grief experience and how constant exposure to critically ill patients influenced their work with patients. All semi-structured interviews were held in the presence of a faculty member of the psychiatry department of Iran University of Medical Sciences. The interview on the grief experience among ICU staff during the COVID-19 pandemic, consists of 4 issues: Familiarity, Experience during the COVID-19 pandemic, Grieving the loss of a family member and Effects of parallel grief.ResultsWe found five common themes in the result of the experiences of the participants based on content analysis. These consisted of: complex grieving process, new experiences for coping with loss, more empathy for patients, change the meaning of death, and the need for support in work places. Likewise, there were 22 sub themes.ConclusionPaying attention to the details of staff members' life, gender differences, and cultural aspects can give us a better understanding and perception of their grief experiences. This understanding brings out valuable points which can help policy makers pass better laws for the wellbeing of society and people in order to promote leadership in turbulent times.
Degarelix vs. leuprorelin for the treatment of prostate cancer in China: A cost-utility analysis
Authors: Yan Jianzhou , Li Caiyun , Zhang Xuefang , Cheng Luyan , Ding Ruilin , Zhang Lingli 
Published: July 2022

ObjectiveTo explore the cost-effectiveness of degarelix acetate for injection (degarelix) compared to leuprorelin in prostate cancer (Pca) castration treatment from Chinese healthcare system perspective.MethodsA Markov model, adapted from the one established in Finland was conducted for the cost-effectiveness analysis of degarelix and leuprorelin for Pca treatment. The main data were derived from global phase III clinical trials of degarelix (CS21), published study and expert surveys. Outcomes, utility and costs of prostate cancer patients were calculated on a 30-year time horizon. The CS21 study based population of intention-to-treat (ITT) population and three scenarios were modeled. Taking three times of the Gross domestic product (GDP) per capita (242,928 yuan, 2021) as the acceptable threshold for cost-effectiveness. One-way and probabilistic sensitivity analyses were performed on key parameters, including transition probabilities, costs, utility, and discount rate to test the robustness of the model.ResultsBase case analysis for ITT population revealed that total costs of degarelix and leuprorelin were 566,226 yuan and 489,693 yuan, while the total quality-adjusted life years (QALYs) were 5.19 and 4.51 during the 30-year time horizon, resulting an incremental cost effectiveness ratio (ICER) of 112,674 yuan/QALY which was 1.39 times the GDP per capita, lower than willingness-to-pay level of three times the GDP per capita. The results for scenario analyses revealed that compared to leuprorelin, degarelix for Pca treatment in China was cost-effective. One-way sensitivity analysis showed that the model was most sensitive to price of 80 mg degarelix, utility of 1st-line therapy, hazard ratio of PSA recurrence, price of 3.75 mg leuprorelin, response rate of docetaxel per cycle, and discount rate of cost. In probabilistic sensitivity analysis, compared to leuprorelin, the probability of degarelix to be cost-effective was 53 and 81% for willingness-to-pay threshold of one and three times the GDP per capita.ConclusionCompared to leuprorelin, degarelix for prostate cancer treatment is cost-effective. Moreover, scenario, one-way, and probabilistic sensitivity analyses revealed that the model was robust.
Targeting Impaired Nutrient Sensing via the Glycogen Synthase Kinase-3 Pathway With Therapeutic Compounds to Prevent or Treat Dementia: A Systematic Review
Authors: Matysek Adrian , Kimmantudawage Sumudu Perera , Feng Lei , Maier Andrea B. 
Published: July 2022

Background: Dementia is a global challenge with 10 million individuals being diagnosed every year. Currently, there are no established disease-modifying treatments for dementia. Impaired nutrient sensing has been implicated in the pathogenesis of dementia. Compounds that inhibit the glycogen synthase kinase-3 (GSK3) pathway have been investigated as a possible treatment to attenuate the progression of the disease, particularly the suppression of the hyper-phosphorylation process of the tau protein.Aims: Systematically summarizing compounds which have been tested to inhibit the GSK3 pathway to treat cognitive impairment and dementia.Methods: PubMed, Embase and Web of Science databases were searched from inception until 28 July 2021 for articles published in English. Interventional animal studies inhibiting the GSK3 pathway in Alzheimer’s disease (AD), Parkinson’s dementia, Lewy body dementia, vascular dementia, mild cognitive impairment (MCI) and normal cognitive ageing investigating the change in cognition as the outcome were included. The Systematic Review Centre for Laboratory animal Experimentation’s risk of bias tool for animal studies was applied.Results: Out of 4,154 articles, 29 described compounds inhibiting the GSK3 pathway. All studies were based on animal models of MCI, AD or normal cognitive ageing. Thirteen out of 21 natural compounds and five out of nine synthetic compounds tested in MCI and dementia animal models showed an overall positive effect on cognition. No articles reported human studies. The risk of bias was largely unclear.Conclusion: Novel therapeutics involved in the modulation of the GSK3 nutrient sensing pathway have the potential to improve cognitive function. Overall, there is a clear lack of translation from animal models to humans.
Strategic Planning and Performance Management for Citizens of Harghita County with the Introduction of the CAF Based Quality Management Tool (CAFHR) Project
Authors: Erdőssy Imre , Kerekes László , Szőcs István 
Published: July 2022

Abstract
The Harghita County Council has decided to carry out a self-assessment to evaluate the adequacy of its processes in the framework of a complex organizational development project using the CAF (Common Assessment Framework). The outcome of the performed self-assessment showed the capabilities and results of the operation, as well as the tasks of ensuring short- and medium-term development. This article aims to point out the needs and possibilities for improving administrative processes by presenting the experiences of the project. An important experience of the project is to prove the necessity of taking into account the specific features in addition to prove the general applicability of the model.
Chronic traumatic diaphragmatic hernia: A case report
Authors: Zambrano Morales Rudy Jhair 
Published: July 2022

Abstract
A diaphragmatic hernia is a very rare pathology, and clinical suspicion is needed for its diagnosis, and in cases of closed trauma it is much more frequently. For a correct diagnosis in chronic cases we should focus the importance of personal record and imaging studies, because the signs and symptoms may go unnoticed. In this sense, the objective is to describe the main clinical manifestations a diaphragmatic hernia, its approach and, diagnosis. The patient went to the Portoviejo Medical Clinic for a different reason and when performing a chest x-ray, the diagnosis of chronic diaphragmatic hernia was outlined. Currently, the treatment of choice is laparoscopy, but the patient presented complications and had to undergo an open surgical procedure. Conclusions: in order to reduce mortality and complications, a correct diagnosis must be made, recognizing by signs, symptoms and images if we are facing an acute or chronic condition; and always take into account personal record, as that can give the clue that helps in the diagnosis and early treatment.
Keywords: Chronic traumatic diaphragmatic hernia; complications; closed chest trauma.
Les fonds Russie et Europe médiane : des collections aux carrefours des langues et des cultures
Authors: Maître Anne 
Published: July 2022

La Bibliothèque Diderot de Lyon (BDL) abrite de vastes et riches collections d’hier et d’aujourd’hui consacrées à la civilisation russe et slave, désignées sous le nom de « fonds Russie et Europe médiane ». Plusieurs fonds composent ces collections. Notre établissement a d’abord accueilli en 2002 une prestigieuse bibliothèque jésuite, la Bibliothèque slave de Meudon, créée au milieu du xixe siècle, et ensuite de nombreux dons prodigués par de grands scientifiques – linguistes, philologues, historiens. L’objectif principal de cet article est de mettre en lumière des livres rares, précieux, singuliers et liés, d’une manière ou d’une autre, à des problématiques de linguistique et de traduction des langues slaves. Cette présentation est tout d’abord une excellente opportunité de rendre hommage aux savants, polyglottes et experts en langues slaves qui ont construit les collections de la BDL au fil des années. C’est aussi un voyage à travers ces langues en compagnie de grands représentants de la culture russe ou d’éminents slavistes, à la découverte de moments particuliers de l’histoire de la Russie et de l’Europe centrale et orientale.