bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats
Authors: Zhang Qian , Xiao Xinhua , Li Ming , Yu Miao , Ping Fan 
Published: August 2022

Diabetic nephropathy (DN) is a severe diabetic complication of the kidney and is the main cause of end-stage kidney disease worldwide. Cordyceps sinensis (C. sinensis) is not only a traditional Chinese medicine (TCM) but also a healthy food. In China, C. sinensis has been widely used to treat various kidney diseases. Bailing Capsule, which active ingredient is C. sinensis, is approved to treat kidney disease, respiratory disease, and immune disease. However, its underlying mechanism in DN remains unclear. The purpose of the present study was to investigate the underlying mechanism of Bailing Capsule on kidney in diabetic rats. The DN model was established by streptozotocin (STZ) injection. Low and high doses of Bailing Capsule were orally administrated for 12 weeks after diabetes induction. Renal function was evaluated by serum creatinine, blood urea nitrogen, 24-h urinary protein, and urinary albumin. Mesangial matrix expansion and renal fibrosis were measured using histopathology staining. We found that the disorder of renal function and pathology in DN rats was significantly modified by Bailing Capsule treatment. Consistently, Bailing Capsule markedly alleviated DN rat glomerulosclerosis, tubulointerstitial injury and renal fibrosis as shown by pathological staining. Moreover, Bailing Capsule significantly reduced the kidney triglyceride content and renal lipid droplet formation in DN rats. The renal transcriptome revealed that Bailing Capsule-treated kidneys had 498 upregulated genes and 448 downregulated genes. These differentially expressed genes were enriched in the peroxisome proliferator activated receptor (PPAR) pathway and fatty acid metabolism function ontology. mRNA and protein expression analyses revealed substantial enhancement of the lipolysis pathway and inhibition of lipogenesis in Bailing Capsule-treated rat kidneys compared to DN rats. Bailing Capsule activated the expression of PPARα, ACOX1 (acyl-CoA oxidase 1), and SCD (stearoyl-CoA desaturase) in diabetic nephropathy while suppressing the expression of FASN (fatty acid synthase). In conclusion, Bailing Capsule could attenuate renal triglyceride accumulation in diabetic rats by moderating PPARα pathway.
Exosomes in pathogenesis, diagnosis, and treatment of pulmonary fibrosis
Authors: Yang Yang , Liu Yufei , Chai Yilu , Liu Ke , Hu Wei , Zhao Keni , Zhu Yi , Gao Peiyang , Huang Qingsong , Zhang Chuantao 
Published: August 2022

Pulmonary fibrosis (PF) is a group of interstitial lung diseases that seriously endanger human life and health. Despite the current advances in research on the pathogenesis and treatment of PF, the overall quality of survival and survival rates of PF patients remain low, prompting the search for more effective therapeutic approaches. Exosomes are nanoscale vesicles with diameters ranging from approximately 30–150 nm, capable of transporting a variety of molecules in the body and mediating intercellular communication. There is an increasing number of studies focusing on the role of exosomes in PF. This review demonstrates the significance of exosomes in the pathogenesis, diagnosis, and treatment of PF. Exosomes are able to influence inflammatory, immune, and extracellular matrix deposition processes in PF and regulate the corresponding cytokines. Some exosomes detected in sputum, blood, and bronchoalveolar lavage fluid may be used as potential diagnostic and prognostic biomarkers for PF. Exosomes derived from several cells, such as mesenchymal stem cells, have demonstrated potential as PF therapeutic agents. Drug delivery systems using exosomes may also provide new insights into PF therapy.
The therapeutic efficacy of resveratrol for acute lung injury—A meta−analysis of preclinical trials
Authors: Tang Yin , Fu Wenqiao , Wei Ke , Liu Ling , Wu Siqi , Tang Wenjing 
Published: August 2022

Background: Resveratrol (RES) has a protective effect on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Our purpose was to conduct a meta−analysis to investigate the efficacy of RES for ALI/ARDS in animal models.Methods: PubMed, EMBASE and Web of Science were searched to screen relevant preclinical trials. The standardized mean difference (SMD) was used to compare the lung injury score, lung wet−dry weight ratio (W/D ratio), tumor necrosis factor−α (TNF−α), interleukin−1β (IL−1β), IL−6, IL−10, the number of neutrophils in bronchoalveolar lavage fluid (BALF) and the total protein in BALF between the treatment and control groups. SYRCLE’s risk of bias tool was used for quality assessment.Results: A total of 17 studies published from 2005 to 2021 were included in our study to calculate the SMD with corresponding confidence interval (CI). As compared with controls, RES significantly decreased the lung injury score (SMD −2.06; 95% CI −2.77, −1.35; p &lt; 0.00001) and W/D ratio (SMD −1.92; 95% CI −2.62, −1.22; p &lt; 0.00001). RES also reduced the number of neutrophils in BALF (SMD −3.03; 95% CI −3.83, −2.24; p &lt; 0.00001) and the total protein in BALF (SMD −5.59; 95% CI −10.10, −1.08; p = 0.02). Furthermore, RES was found to downregulate proinflammatory mediators such as TNF−α (SMD −2.02; 95% CI −3.09, −0.95; p = 0.0002), IL−1β (SMD −2.51; 95% CI −4.00, −1.02; p = 0.001) and IL−6 (SMD −2.26; 95% CI −3.49, −1.04; p = 0.0003). But RES had little effect on the anti−inflammatory mediators such as IL−10 (SMD 2.80; 95% CI −0.04, 5.63; p = 0.05). Sensitivity analysis and stratified analysis were performed for the outcome indicators with heterogeneity.Conclusion: RES treatment is effective on reducing the severity of ALI. However, more animal studies and human trials are needed for further investigation. Our study may provide a reference for preclinical and clinical studies in the future to some extent.
LINC-PINT suppresses cisplatin resistance in gastric cancer by inhibiting autophagy activation via epigenetic silencing of ATG5 by EZH2
Authors: Zhang Cheng , Kang Tong , Wang Xinyi , Wang Jizhao , Liu Lin , Zhang Jiawei , Liu Xu , Li Rong , Wang Jiansheng , Zhang Jia 
Published: August 2022

Resistance to cisplatin (DDP) is a major obstacle in the clinical treatment of advanced gastric cancer (GC). Long noncoding RNA (lncRNA) play a significant regulatory role in the development and drug resistance of GC. In this study, we reported that the lncRNA LINC-PINT was downregulated in DDP-resistant GC cells. Functional studies showed that LINC-PINT inhibited proliferation and migration of DDP-resistant GC cells in vitro, and overexpression of LINC-PINT could enhance the sensitivity of DDP-resistant GC cells to DDP. Further investigation revealed that LINC-PINT recruited enhancer of zeste homolog 2 (EZH2) to the promotor of ATG5 to inhibit its transcription, leading to the suppression of autophagy and DDP resensitization. Collectively, our results revealed how the LINC-PINT/EZH2/ATG5 axis regulates autophagy and DDP resistance in GC. These data suggest that LINC-PINT may be a potential therapeutic target in GC.
Factoring and correlation in sleep, fatigue and mental workload of clinical first-line nurses in the post-pandemic era of COVID-19: A multi-center cross-sectional study
Authors: Liu Yan , Xian Ji Shu , Wang Rui , Ma Kang , Li Fei , Wang Fei Long , Yang Xue , Mu Ning , Xu Kai , Quan Yu Lian , Wang Shi , Lai Ying , Yang Chuan Yan , Li Teng , Zhang Yanchun , Tan Binbin , Feng Hua , Chen Tu Nan , Wang Li Hua 
Published: August 2022

BackgroundA better understanding of the factors and their correlation with clinical first-line nurses’ sleep, fatigue and mental workload is of great significance to personnel scheduling strategies and rapid responses to anti-pandemic tasks in the post-COVID-19 pandemic era.ObjectiveThis multicenter and cross-sectional study aimed to investigate the nurses’ sleep, fatigue and mental workload and contributing factors to each, and to determine the correlation among them.MethodsA total of 1,004 eligible nurses (46 males, 958 females) from three tertiary hospitals participated in this cluster sampling survey. The Questionnaire Star online tool was used to collect the sociodemographic and study target data: Sleep quality, fatigue, and mental workload. Multi-statistical methods were used for data analysis using SPSS 25.0 and Amos 21.0.ResultsThe average sleep quality score was 10.545 ± 3.399 (insomnia prevalence: 80.2%); the average fatigue score was 55.81 ± 10.405 (fatigue prevalence: 100%); and the weighted mental workload score was 56.772 ± 17.26. Poor sleep was associated with mental workload (r = 0.303, P &lt; 0.05) and fatigue (r = 0.727, P &lt; 0.01). Fatigue was associated with mental workload (r = 0.321, P &lt; 0.05). COVID-19 has caused both fatigue and mental workload. As 49% of nurses claimed their mental workload has been severely affected by COVID-19, while it has done slight harm to 68.9% of nurses’ sleep quality.ConclusionIn the post-COVID-19 pandemic era, the high prevalence of sleep disorders and fatigue emphasizes the importance of paying enough attention to the mental health of nurses in first-class tertiary hospitals. Efficient nursing strategies should focus on the interaction of sleep, fatigue and mental workload in clinical nurses. In that case, further research on solutions to the phenomenon stated above proves to be of great significance and necessity.Clinical trial registration[https://clinicaltrials.gov/], identifier [ChiCTR2100053133].
Parent perspectives about pediatric urology telemedicine visits before and after COVID-19-driven rapid implementation
Authors: Walton Ryan F. , Arora Hans C. , Berkowitz Rachel J. , Rosoklija Ilina , Cheng Earl Y. , Johnson Emilie K. 
Published: August 2022

Research ObjectiveTelemedicine is now a critical healthcare delivery modality. Prior studies of telemedicine in pediatric urology are lacking parent/patient perspectives. This study aims to assess interest in and factors associated with willingness to participate in telemedicine, and to compare perceptions of telemedicine before and after pandemic-related implementation.Study DesignThis was a cross-sectional study of parents of pediatric urology patients that attended in-person clinic visits (Pre-Telemedicine cohort; January-March 2020) and telemedicine visits (Post-Telemedicine cohort; April-July 2020).Principal FindingsThe response rates were 83.4% (Pre-Telemedicine, N =205) and 32.5% (Post-Telemedicine, N =89). Overall, most parents had a college or graduate level degree (71.9%), private insurance (71.6%), and a plurality were 36-40 years old (30.7%). Their children were mostly white (68.9%), 23.7% were Hispanic/Latino, and the median patient age was 3.3 years (range: 0.1–32.1). There were no demographic differences between the Pre-and-Post-Telemedicine sub-groups.Pre-TelemedicineMost (84.3%) were willing to participate in a new, follow-up, or post-operative telemedicine visit. There were no associations between demographics and willingness. Comfort in video visits without a physical exam (3.23% Unwilling vs 38.2% Willing, = &lt;0.001), comfort with technology (22.6% vs 71.6%, p = &lt;0.001), belief that quality of care is similar between telemedicine and in-person visits (3.23% vs 24.0%, p = &lt;0.001), and estimated costs from in-person visits (6.67% vs 30.3%, p = 0.004) were all positively associated with willingness.Post-TelemedicineMost indicated that telemedicine met their needs (88.6%), and that they were satisfied with the both the quality of technology used (83%) and the interaction with the urologist (89.9%) during the telemedicine visit.Comparison of Pre-and-Post-TelemedicineIn reference to the Pre-Telemedicine respondents, Post-Telemedicine respondents more frequently strongly agreed that telemedicine is as private (51.5% vs 77.5%, p = &lt;0.001), secure (49.5% vs 66.3%, p = 0.02), and complete (33.2% vs 51.1%, p = 0.02) as in-person visits.ConclusionsMost parents had high willingness to participate and positive perceptions of telemedicine prior to the COVID-19 era. Factors associated with willingness were elucidated. Families that participated in telemedicine reduced direct costs and saved time. Lastly, these results suggest that confidence in telemedicine had increased after experience with telemedicine. These data support continued telemedicine access and coverage/reimbursement beyond the pandemic.
Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females
Authors: Zhang Jie , Ma Binbin , Ji Hong , Guo Rong 
Published: August 2022

BackgroundPrimary breast lymphoma (PBL) is a rare disease condition and is mainly observed in females. No male PBL cohorts were reported previously. This study aims to investigate the incidence, clinical characteristics, prognostic factors, and survival outcomes among male PBL patients and also to perform comparisons between males and females.MethodsPatients diagnosed with PBL between 2000 and 2019 from the Surveillance, Epidemiology, and End Results (SEER) database were identified. Age-adjusted incidence rates were calculated by year and age for trend analysis. Univariate and multivariate Cox hazard proportional regression analyses were performed to identify prognostic factors. Survival comparisons were conducted using the Kaplan–Meier method and the log-rank test. The propensity matching score (PSM) method was used to balance demographics.ResultsThe incidence rate of 122 male PBL patients diagnosed in the period of 2000 to 2019 was 0.169 (95% CI: 0.140–2.203) per million persons, which was much lower than that of 2,543 females (1.59, 95% CI: 1.53–1.65). Clinical demographics were similar between females and males, except for lymphoma subtype distribution (P = 0.025). A higher age [hazard ratio (HR) = 1.08, 95% CI: 1.05–1.12, P &lt; 0.001] and not receiving radiotherapy (receiving vs. not receiving: HR = 0.41, 95% CI: 0.21–0.78, P = 0.007) were significant risk factors associated with overall survival (OS) in males. Radiotherapy (OS: P = 0.023) can offer benefits in OS. Using the PSM method, we also revealed that male PBL patients had significantly worse OS and cancer-specific survival rates than females.ConclusionsThis study first analyzed male patients with PBL involving incidence, clinical characteristics, and survival data. Sex disparity was also observed in the survival outcome of the disease.
Substance Use Among Residents of Homeless Shelters During the COVID-19 Pandemic: Findings From France
Authors: Scarlett Honor , Melchior Maria , Davisse-Paturet Camille , Aarbaoui Tarik El. , Longchamps Cécile , Figueiredo Natasha , Ducarroz Simon 
Published: August 2022

Objectives: To record the prevalence and risk factors of substance use amongst homeless persons during the COVID-19 pandemic.Methods: The ECHO study consisted in two independent cross-sectional waves of data collection in the regions of Paris, Lyon, and Strasbourg during the Spring of 2020 (n = 530) and 2021 (n = 319). Factors associated with substance use were explored using generalised logistic regression models.Results: The most prevalent substance used was tobacco (38%–43%), followed by alcohol (26%–34%). The use of both substances positively associated with each other, although risk factors varied depending on the substance. The only factors consistently associated with alcohol and tobacco use were being male, exposure to theft/assault and participants’ region of origin. Whilst the rate of tobacco use was relatively stable between Spring 2020 and 2021, alcohol use was more common in 2021.Conclusion: These findings highlight a high prevalence of substance use amongst homeless persons. People experiencing homelessness face specific challenges in the context of the pandemic, alongside greater vulnerability to illness and low healthcare access, therefore the need to improve prevention and support services for substance abuse within this population is vital.
A Multi-Center Study on the Negative Psychological Impact and Associated Factors in Chinese Healthcare Workers 1 Year After the COVID-19 Initial Outbreak
Authors: Gonzalez Mendez Maria Jose , Ma Li , Alvarado Ruben , Ramirez Jorge , Xu Kun-Peng , Xu Hui-Fang , Zhang Shao-Kai , Bangura Mohamed S. , Yang Ying , Yu Yan-Qin , Zhang Xi , Wang Wenjun , Gu Xiaofen , Li Li , Salah Didier Sama , Qiao Youlin 
Published: August 2022

Objectives: The study aimed at analyzing the prevalence of five psychological outcomes (depression, anxiety, stress, post-traumatic stress disorder (PTSD), and suicidal ideation) among Chinese healthcare workers (HCWs), and measured the total possible negative psychological impact 1 year after the COVID-19 initial outbreak.Methods: A cross-sectional nationwide multi-center study was performed between November 2020 and March 2021 in China. A self-report questionnaire was applied, and three psychological scales were used. Binary logistic regression was performed to analyze the risk factors associated with each psychological outcome.Results: The findings demonstrated that the COVID-19 pandemic had a negative psychological impact on HCWs, which was still evident 1 year after the initial outbreak. Nurses showed higher depression and anxiety than other HCWs. Female gender, passive coping, long working hours, having a chronic disease, and experiencing violence, among other factors, were all risk factors for psychological impairment.Conclusion: Developing and promoting programs to improve mental health among HCWs, and identifying those who might need psychological support is still relevant 1 year after the initial outbreak.
Formación histórica del segundo régimen alimentario mundial: período 1950-1970
Authors: Zambrano Argandoña Carlos A. 
Published: August 2022

El proceso de acumulación de capital tiene como uno de sus elementos fundamentales la explotación de la fuerza de trabajo, para que esta exista, es necesaria la ingestión de alimentos. En este sentido, la necesidad de alimentos baratos es determinante en la reproducción del sistema social y la consolidación de un mercado interno periférico. Si a esto se agrega salarios bajos en su cuantía, se debe entender que los alimentos y su precio serán un reflejo de tal situación. El crecimiento histórico de potencias como los Estados Unidos y la Unión Europea a lo largo del siglo XX, determinó competencia entre los dos hegemones por el predominio mundial. En este sentido, una parte importante del proceso se haya conformado por el rubro de los alimentos. Así, el postulado central de este ensayo en relación con la problemática agroalimentaria es que la reproducción ampliada del capital necesita alimentos baratos. Cuestión que no es sencilla, dado que los precios de los productos y materias primas se encuentran supeditados al ciclo económico predominante a nivel mundial.
El almuerzo sobre la hierba, un puente hacia la modernidad
Authors: Fernández Ferrín Carlos A. , Bolívar Chávez Oscar E. , Cruz Mendoza Juan C. 
Published: August 2022

El análisis de Almuerzo sobre la hierba de Manet ha evidenciado la importancia de la pintura en la historia del arte contemporáneo, por su influencia directa en las principales corrientes pictóricas vanguardistas. Elementos como la disposición de personajes y objetos, el uso del color, la amalgama de formas, la vestimenta de las figuras secundarias, así como la desnudez de la protagonista cuya imagen corriente contrasta con el romanticismo pictórico dominante. El homenaje que hace al cuerpo femenino lo convierten en figura rompedora y uno de los primeros representantes del realismo circundante en una época en declive. La obra muestra la relación pragmática de lo clásico con lo moderno porque simboliza la propia realidad del autor insertada en el medio. El reflejo de su inconformidad con lo establecido lo catapulta como referente de un modelo de arte atrevido, una propuesta pictórica respaldada por las teorías y técnicas del arte renacentista y barroco pero transformada por su identidad y visión futurista.
Brecha digital entre estudiantes del área urbana y rural, a partir del estándar de saberes digitales mínimos propuestos por la Unesco
Authors: Cedeño Alcívar Soraya Feliz , Hernández Freya , Morales Intriago Juan Carlos 
Published: August 2022

La cultura digital ha transformado los procesos de comunicación y las interacciones cotidianas, tanto docentes como estudiantes utilizan cada vez más dispositivos móviles para manipular recursos digitales como: redes sociales, correo electrónico, plataformas educativas, bases de datos, foros, entre un sinnúmero de aplicaciones con fines educativos, de comunicación o de entretenimiento. El presente trabajo tiene por objetivo analizar los (SDM) Saberes Digitales Mínimos que deben poseer los estudiantes del nivel superior para desempeñarse en sus tareas de formación académica, además de estimar la brecha digital entre estudiantes que provienen del área rural y el área urbana. La investigación se desarrolla a través del método explicativo. El diseño contempla dos etapas: En la primera se realizó un análisis documental, para fundamentar con teorías el presente trabajo. En la segunda se aplicó la ficha de esquemas de saberes digitales a partir de las coincidencias entre marcos de referencia propuesta por Ramírez y Casillas (2015), considerando solamente los indicadores propuestos por la UNESCO, para identificar los SDM y determinar la brecha digital entre estudiantes de la carrera de Secretariado Ejecutivo de la Universidad técnica de Manabí provenientes de las áreas geográficas indicadas. El estudio permitió identificar los niveles de competencias digitales mínimas, establecer y analizar la brecha digital, para finalmente proponer alternativas que permitirán reducir esta brecha y potenciar estos nuevos escenarios de la educación.
Perspectivas de género en la educación superior: políticas y lineamientos a partir de un enfoque académico
Authors: Menéndez López Jorge Daniel , Venegas Cadena Laura Ximena , Bermeo Macías Fabricio Gabriel , Peñafiel Pincay Francisco Eloy 
Published: August 2022

Uno de los retos más importantes que enfrentan las instituciones de educación superior es el de erradicar la desigualdad de género que todavía se manifiesta y reproduce a su interior. Desde sus orígenes, las universidades e institutos han sido espacios históricamente desfavorables para las mujeres, quienes durante siglos ni siquiera tuvieron derecho a acceder a este nivel educativo. Por medio de exigencias y luchas continuas, a partir del siglo XIX, las mujeres lograron ingresar a la educación superior, incrementando de forma progresiva su presencia. Sin embargo, muchas desigualdades aún persisten; son notables en el ámbito de la profesión académica (nombramientos y promociones), en las evaluaciones y en el otorgamiento de reconocimientos, en el acceso y la permanencia por áreas y disciplinas, así como en algunos países latinoamericanos, Ecuador incluido. Tampoco es posible olvidar que lamentablemente existen situaciones de acoso, hostigamiento y violencia de género en las instituciones de educación superior. Este trabajo tiene como propósito reflexionar acerca de la manera en que se teje, en el ámbito de la educación superior, la dimensión social del género como elemento que participa de manera fundamental en las relaciones de poder.