bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Urban Heat Effect through Satellite Image Analysis: Focusing on Narayanganj Upazila, Bangladesh
Authors: Md. Razzakul Islam  , Haque Md. Nazmul 
Published: October 2022

The rapid growth of population and land use cover change are closely connected. Narayanganj Sadar Upazila is the first Growing City in Bangladesh. Land use and land cover change are very first. Global warming, increased greenhouse gas emissions, and other environmental issues have become critical issues to address in recent times. Because of the Unplanned Expansion of urban areas, the LULC pattern is changing, and this kind of adverse (LST increasing, Heat Island Growth) impact is increasing. In this area, the amount of vegetation is decreasing day by day. The objectives of this study are to identify land use land cover (LULC) dynamics for the year 2001 to 2021, identify Urban Heat Islands from the value of land surface temperature (LST) and identify hotspots based on normalized difference vegetation index (NDVI), normalized difference built-up index (NDBI), normalized difference water index (NDWI) and land surface temperature (LST) doing weighted overlay among them. To determine the land cover pattern, and change at Narayanganj Upazila in the years 2001, 2011, and 2021, the land cover type was divided into four categories (build-up, vegetation, water bodies, and barren soil) in geographic information system (GIS) and Earth Resources Data Analysis System (ERDAS) Imagine 2014. The overall accuracy of LULC in 2001, 2011, and 2021 was 90.08, 91.34, and 92.02, respectively. And the value of the kappa coefficient for the years 2001, 2011, and 2021 was 0.91, 0.89, and 0.90, respectively. This study demonstrates an increase of 14.22% in built-up area and destruction of 15.5% of vegetation, 3.26% of barren soil, and 1.05% of the waterbody in the previous 21 years in Narayanganj Upazila. This study will help the administration, agricultural directorates, Pourashava office, and city corporation authority to take necessary measures to mitigate the adverse impacts of land cover change. They can make new rules and regulations on the construction of buildings, restrictions on filling water bodies and measures to conserve vegetation.
Global urban exposure projections to extreme heatwaves
Authors: Marcotullio Peter J. , Keßler Carsten , Fekete Balázs M. 
Published: October 2022

Over the past decades, the world has experienced increasing heatwave intensity, frequency, and duration. This trend is projected to increase into the future with climate change. At the same time, the global population is also projected to increase, largely in the world’s cities. This urban growth is associated with increased heat in the urban core, compared to surrounding areas, exposing residents to both higher temperatures and more intense heatwaves than their rural counterparts. Regional studies suggest that Asia and Africa will be significantly affected. How many people may be exposed to levels of extreme heat events in the future remains unclear. Identifying the range in number of potentially exposed populations and where the vulnerable are located can help planners prioritize adaption efforts. We project the ranges of population exposed to heatwaves at varying levels to 2,100 for three future periods of time (2010–2039, 2040–2069, 2070–2099) using the Shared Socio-Economic Pathways (SSPs) and the Representative Concentration Pathways (RCPs). We hypothesize that the largest populations that will be exposed to very warm heatwaves are located in Asia and Africa. Our projections represent the warmest heatwaves for 15 days during these three periods. By the 2070–2099 period, the exposure levels to extreme heatwaves (&gt;42°) exceed 3.5 billion, under the sustainability scenario (RCP2.6-SSP1). The number of those exposed in cities climbs with greater projected climate change. The largest shares of the exposed populations are located in Southern Asia and tropical countries Western and Central Africa. While this research demonstrates the importance of this type of climate change event, urban decision-makers are only recently developing policies to address heat. There is an urgent need for further research in this area.
Left vs. right radial approach for coronary catheterization: Relation to age and severe aortic stenosis
Authors: Will Maximilian , Weiss Thomas W. , Weber Michael , Kwok Chun Shing , Borovac Josip A. , Lamm Gudrun , Unterdechler Markus , Aufhauser Simone , Nolan Jim , Mascherbauer Julia , Schwarz Konstantin 
Published: October 2022

BackgroundOld age and the presence of aortic stenosis are associated with the unfolding of the intrathoracic aorta. This may result in increased difficulties navigating catheters from the right compared to the left radial approach.ObjectiveTo investigate whether increasing age or presence of severe aortic stenosis was associated with increased catheterization success rates from left (LRA) compared to right radial artery approach (RRA).MethodsWe compared coronary angiography success rates of RRA and LRA according to different age groups and in a subgroup of patients with severe aortic stenosis.ResultsA total of 21,259 coronary angiographies were evaluated. With increasing age, the first pass success rate from either radial access decreased significantly (p &lt; 0.001). In patients aged &lt;85 years, there was no difference between LRA and RRA. However, in patients aged ≥85 years, LRA was associated with significantly higher success rates compared to RRA (90.1 vs. 82.8%, p = 0.003). Patients aged ≥85 years received less contrast agent and had shorter fluoroscopy time when LRA was used [86.6 ± 41.1 vs. 99.6 ± 48.7 ml (p &lt; 0.001) and 4.5 ± 4.1 min vs. 6.2 ± 5.7 min (p &lt; 0.001), mean (±SD)]. In patients with severe aortic stenosis (n = 589) better first pass success rates were observed via LRA compared to the RRA route (91.9 vs. 85.1%, p = 0.037).ConclusionLRA, compared to RRA, is associated with a higher first-pass catheter success rate for coronary artery angiography in patients aged ≥85 years and those with severe aortic stenosis.
In-hospital major bleeding in patients with acute coronary syndrome medically treated with dual anti-platelet therapy: Associated factors and impact on mortality
Authors: Sun Yihong , Feng Lin , Li Xian , Wang Zhe , Gao Runlin , Wu Yangfeng 
Published: October 2022

ObjectiveMajor bleeding is associated with poor hospital prognosis in patients with acute coronary syndrome (ACS). Despite its clinical importance, there are limited studies on the incidence and risk factors for major bleeding in ACS patients with dual anti-platelet therapy (DAPT) without access to revascularization.MethodsWe analyzed data from 19,186 patients on DAPT after ACS with no access to revascularization from Clinical Pathway for Acute Coronary Syndrome in China Phase 3 (CPACS-3) cohort, which was conducted from 2011 to 2014. Major bleeding included intracranial hemorrhage, clinically significant bleeding, or bleeding requiring blood transfusion. Factors associated with in-hospital major bleeding were assessed using Poisson regressions with generalized estimating equations to account for the clustering effect.ResultsA total of 75 (0.39%) patients experienced major bleeding during hospitalization. Among subtypes of ACS, 0.65% of patients with STEMI, 0.33% with NSTEMI, and 0.13% with unstable angina had in-hospital major bleeding (p &lt; 0.001). The patients who experienced major bleeding had a longer length of stay (median 12 vs. 9 days, p = 0.011) and a higher all-cause in-hospital death rate (22.7 vs. 3.7%, p &lt; 0.001). Multivariable analysis showed advancing age (RR = 1.52 for every 10 years increase, 95% CI: 1.13, 2.05), impaired renal function (RR = 1.79, 95% CI: 1.10, 2.92), use of fibrinolytic drugs (RR = 2.93, 95% CI: 1.55, 5.56), and severe diseases other than cardiovascular and renal diseases (RR = 5.56, 95% CI: 1.10, 28.07) were associated with increased risk of major bleeding, whereas using renin–angiotensin system inhibitors (RR = 0.54, 95% CI: 0.36, 0.81) was associated with decreased risk of major bleeding. These independent factors together showed good predictive accuracy with an AUC of 0.788 (95% CI: 0.734, 0.841).ConclusionAmong ACS patients on DAPT, advancing age, impaired renal function, thrombolytic treatment, and severe comorbidities were independently associated with a higher risk of in-hospital major bleeding.
Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women
Authors: Sun Xingyu , Xiong Wang , Liu Liting , Xiong Junjun , Liao Chenlu , Lan Yunzhu , Li Feifei , Tao Shufei , Meng Muzi , Sun Chenyu , Mao Xiguang 
Published: October 2022

ObjectivesThe aim of this study was to compare the predictive capability of antral follicle count (AFC) and the anti-Müllerian hormone (AMH) on ovarian response in infertile women and to identify potential factors influencing retrieved oocytes.MethodsA total of 2585 infertile women who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles had been enrolled in this study. Spearman correlation was used to investigate the correlation between retrieved oocytes and AFC. Multiple linear regression analysis was used to study the parameters affecting the number of retrieved oocytes.ResultsSpearman correlation and multiple linear regression analysis revealed that the oocyte retrieval number was positively correlated with AFC (r = 0.651, p &lt; 0.001) and AMH (r = 0.566, p &lt; 0.001) and negatively correlated with age (r = -0.425, p &lt; 0.001) and regimen selection (r = -0.233 p &lt; 0.001). There was no significant correlation between retrieved oocytes and BMI (p = 0.913). ROC analysis revealed that AFC was a better predictor of adverse effects than AMH, BMI, and age (AUC: 0.916 VS 0.791, 0.575, 0.752). Meanwhile, AFC and AMH were comparable in predicting high response (AUC = 0.731 and AUC = 0.733, respectively).ConclusionsThis study showed that retrieved oocytes were positively correlated with serum AMH and AFC and negatively correlated with age and BMI. AFC had an ideal predictive performance in ovarian response prediction. The mechanism of the effect of AFC on ovarian response during controlled ovarian hyperstimulation (COH) needs to be further investigated.
Effectiveness of lifestyle interventions for treatment of overweight/obesity among children in China: A systematic review and meta-analysis
Authors: Li Bo , Gao Shan , Bao Wei , Li Ming 
Published: October 2022

BackgroundPediatric obesity has become a global public health problem. China has the largest population of obese children in the world. It is important to develop effective interventions to control child obesity. This systematic review summarizes proof from randomized controlled trials to assess the efficacy of lifestyle intervention to reduce BMI and metabolic risk factors for overweight/obese Chinese children.MethodsWe searched studies from five databases (PubMed, MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and CNKI). Research that meets the following requirements was included: randomized controlled trials, participants are overweight/obese Chinese children aged &lt;18 years old, and the effectiveness of lifestyle interventions is evaluated.ResultsEight randomized controlled trials were included. A significant difference was found between the intervention group and the control group for the BMI changes (mean difference = −1.49; 95% CI: −2.20 to -0.77; p &lt; 0.001). Subgroup analyses consistently demonstrated that effects of lifestyle interventions on BMI change including multiple-component interventions (mean difference = −2.03 kg/m2; 95% CI: −3.62 to -0.43; p &lt; 0.001) were stronger than those only with physical activities or health education; effects of lifestyle interventions on BMI change were also strengthened if duration of intervention last for more than 1 year (mean difference = −3.03 kg/m2; 95% CI: −4.00 to -2.06; p = 0.01) or with age during 12-18 years old (mean difference = −1.90 kg/m2; 95% CI: −3.37 to -0.43; p &lt; 0.001).ConclusionsLifestyle interventions are effective in reducing BMI in Chinese children with overweight/obesity, and the effectiveness is more profound when the lifestyle intervention includes multiple components, lasts longer than one year, and/or is conducted among teens. These findings provide an important evidence base for developing and implementing potentially effective lifestyle interventions for the treatment of overweight/obesity among Chinese children.
Effect of transfer learning on the performance of VGGNet-16 and ResNet-50 for the classification of organic and residual waste
Authors: Wu Fangfang , Lin Hao 
Published: October 2022

It is crucial to realize the municipal solid waste (MSW) classification in terms of its treatments and disposals. Deep learning used for the classification of residual waste and wet waste from MSW was considered as a promising method. While few studies reported using the method of deep learning with transfer learning to classify organic waste and residual waste. Thus, this study aims to discuss the effect of the transfer learning on the performance of different deep learning structures, VGGNet-16 and ResNet-50, for the classification of organic waste and residual waste, which were compared in terms of the training time, confusion matric, accuracy, precision, and recall. In addition, the algorithms of PCA and t-SNE were also adopted to compare the representation extracted from the last layer of various deep learning models. Results indicated that transfer learning could shorten the training time and the training time of various deep learning follows this order: VGGNet-16 (402 s) &gt; VGGNet-16 with TL (272 s) &gt; ResNet-50 (238 s) &gt; ResNet-50 with TL (223 s). Compared with the method of PAC, waste representations were better separated from high dimension to low dimension by t-SNE. The values of organic waste in terms of F1 score follows this order: ResNet-50 with transfer learning (97.8%) &gt; VGGNet-16 with transfer learning (97.1%) &gt; VGGNet-16 (95.0%) &gt; ResNet-50 (92.5%).Therefore, the best performance for the classification of organic and residual waste was ResNet-50 with transfer learning, followed by VGGNet-16 with transfer learning and VGGNet-16, and ResNet-50 in terms of accuracy, precision, recall, and F1 score.
Linguistic spin in randomized controlled trials about age-related macular degeneration
Authors: Veldhuis Nienke , Nuijts Myrthe A. , Isphording Luka , Lee-Kong Felicia V. Y. L. , Imhof Saskia M. , Stegeman Inge 
Published: October 2022

ObjectiveTo evaluate the prevalence, type and extent of linguistic spin in randomized controlled trials (RCTs) exploring interventions in patients with age-related macular degeneration (AMD), as well as to investigate whether study variables were correlated with linguistic spin.Study design and settingPubMed was searched from 2011 to 2020 to identify RCTs including patients with AMD. Two authors independently assessed a total of 96 RCTs. Linear regression analyses were performed to investigate whether linguistic spin was correlated with predefined study variables.ResultsLinguistic spin was found in 61 of 96 abstracts (63.5%) and in 90 of 96 main texts (93.8%). Use of words pointing out the beneficial effect of a treatment and the use of ‘(statistically) significant/significance' without reporting a P-value or a 95% confidence interval (CI) were the most frequently identified categories of linguistic spin. Sample size was significantly correlated with the total linguistic spin score (95% CI 0.38–5.23, P = 0.02).ConclusionA high prevalence and extent of linguistic spin in RCTs about AMD was found. We highlighted the importance of objective reporting and awareness of linguistic spin among ophthalmologists and other readers.
SARS-CoV-2 modulates inflammatory responses of alveolar epithelial type II cells via PI3K/AKT pathway
Authors: Al-Qahtani Ahmed A. , Pantazi Ioanna , Alhamlan Fatimah S. , Alothaid Hani , Matou-Nasri Sabine , Sourvinos George , Vergadi Eleni , Tsatsanis Christos 
Published: October 2022

BackgroundSARS-CoV-2 infects through the respiratory route and triggers inflammatory response by affecting multiple cell types including type II alveolar epithelial cells. SARS-CoV-2 triggers signals via its Spike (S) protein, which have been shown to participate in the pathogenesis of COVID19.AimAim of the present study was to investigate the effect of SARS-CoV2 on type II alveolar epithelial cells, focusing on signals initiated by its S protein and their impact on the expression of inflammatory mediators.ResultsFor this purpose A549 alveolar type II epithelial cells were exposed to SARS CoV2 S recombinant protein and the expression of inflammatory mediators was measured. The results showed that SARS-CoV-2 S protein decreased the expression and secretion of IL8, IL6 and TNFα, 6 hours following stimulation, while it had no effect on IFNα, CXCL5 and PAI-1 expression. We further examined whether SARS-CoV-2 S protein, when combined with TLR2 signals, which are also triggered by SARS-CoV2 and its envelope protein, exerts a different effect in type II alveolar epithelial cells. Simultaneous treatment of A549 cells with SARS-CoV-2 S protein and the TLR2 ligand PAM3csk4 decreased secretion of IL8, IL6 and TNFα, while it significantly increased IFNα, CXCL5 and PAI-1 mRNA expression. To investigate the molecular pathway through which SARS-CoV-2 S protein exerted this immunomodulatory action in alveolar epithelial cells, we measured the induction of MAPK/ERK and PI3K/AKT pathways and found that SARS-CoV-2 S protein induced the activation of the serine threonine kinase AKT. Treatment with the Akt inhibitor MK-2206, abolished the inhibitory effect of SARS-CoV-2 S protein on IL8, IL6 and TNFα expression, suggesting that SARS-CoV-2 S protein mediated its action via AKT kinases.ConclusionThe findings of our study, showed that SARS-CoV-2 S protein suppressed inflammatory responses in alveolar epithelial type II cells at early stages of infection through activation of the PI3K/AKT pathway. Thus, our results suggest that at early stages SARS-CoV-2 S protein signals inhibit immune responses to the virus allowing it to propagate the infection while in combination with TLR2 signals enhances PAI-1 expression, potentially affecting the local coagulation cascade.
Factors predicting regression of visual acuity following successful treatment of anisometropic amblyopia
Authors: Jia Yu , Liu Jing , Ye Qingqing , Zhang Shenglan , Feng Lei , Xu Zixuan , Zhuang Yijing , He Yunsi , Zhou Yusong , Chen Xiaolan , Yao Ying , Jiang Rengang , Thompson Benjamin , Li Jinrong 
Published: October 2022

ObjectiveTo identify factors associated with visual acuity regression following successful treatment of anisometropic amblyopia.Design and methodThis was a retrospective cohort study. Database records for 100 and 61 children with anisometropic amblyopia who met at least one criterion for successful treatment proposed by the Pediatric Eye Disease Investigator Group (PEDIG) and had at least 1 year of follow-up data available after the criterion was met were analyzed. The study sample was split into two groups, those who regressed within 1 year of successful treatment (no longer met any of the PEDIG criteria for successful treatment) and those who did not. A two-step analysis involving a least absolute shrinkage and selection operator (LASSO) regression and a logistic regression were used to identify predictor variables for increased risk of regression. A broad range of clinical, perceptual, and demographic variables were included in the analyses.ResultsSixty-eight (42.5%) children regressed within 1 year of successful treatment. Among the 27 predictor variables considered within the statistical modeling process, the three most important for predicting treatment regression were the extent of amblyopic eye visual acuity improvement, age at first hospital visit and sex. Specifically, lower risk of regression was associated with larger amblyopic eye visual acuity improvement with treatment, younger age at initiation of treatment and female sex.ConclusionPatients who received treatment at a younger age and responded well to treatment had a lower risk of treatment regression. This pattern of results suggests that early detection of amblyopia and strategies that enhance treatment adherence may reduce the risk of treatment regression. The higher risk of regression in boys than girls that we observed may reflect known sex differences in brain development and /or sex differences in environment within our sample of children from South China.
Idiopathic membranous nephropathy with renal amyloidosis: A case report
Authors: Wang Yue , Wang Xueyao , Yu Jinyu , Wu Shan , Xu Zhonggao , Sun Weixia 
Published: October 2022

BackgroundImmunoglobulin light chain amyloidosis is a clonal, non-proliferative plasma cell disorder, in which fragments of immunoglobulin light chain are deposited in tissues. Clinical features depend on organs involved but can include restrictive cardiomyopathy, nephrotic syndrome, hepatic failure, peripheral/autonomic neuropathy, and atypical multiple myeloma. Membranous nephropathy (MN) is a group of diseases characterized by deposition of immune complexes under the epithelial cells of glomerular basement and diffuse thickening of the basement membrane. Most patients with idiopathic MN (IMN) have been exposed to phospholipase A2 receptor (PLA2R) antigen, and anti-PLA2R antibodies that attack podocytes can be detected in their blood. IMN combined with amyloidosis nephropathy without secondary factors is rare. The present study describes a patient with IMN combined with immunoglobulin light chain amyloidosis nephropathy.Case reportA 39-year-old man was admitted to our hospital because of weight loss and edema. His clinical manifestation was nephrotic syndrome. Renal pathology revealed MN. A positive Congo red staining and the pathognomonic apple-green birefringence under cross-polarized light were considered to be associated with amyloid nephropathy. Immunofluorescence showed that λ light chain was positive. Heavy chain deposition disease and amyloid-associated protein amyloidosis were excluded by immunofluorescence and immunohistochemistry, respectively. Subsequent examinations showed that his serum was negative for antibodies against the PLA2R, but PLA2R was present in renal tissue. The final diagnosis was IMN with light chain amyloid nephropathy.ConclusionRenal amyloidosis accompanied by IMN is uncommon. Attention should be paid to the subtype of the disease and the exclusion of secondary factors. Perfect clinical and pathological examination are helpful for the classification and staging of the disease. Congo red staining, light microscopy, immunofluorescence, immunohistochemistry, electron microscopic examination, pathological tissue staining for PLA2R antigen and testing for anti-PLA2R antibody in serum are helpful.