bluuebunny/crossref_metadata_2025_split huggingface dataset:
How are ontologies implemented to represent clinical practice guidelines in clinical decision support systems: protocol for a systematic review
Authors: Sadeghi-Ghyassi Fatemeh , Damanabi Shahla , Kalankesh Leila R. , Van de Velde Stijn , Feizi-Derakhshi Mohammad-Reza , Hajebrahimi Sakineh 
Published: August 2022

Abstract
Background
Clinical practice guidelines are statements which are based on the best available evidence, and their goal is to improve the quality of patient care. Integrating clinical practice guidelines into computer systems can help physicians reduce medical errors and help them to have the best possible practice. Guideline-based clinical decision support systems play a significant role in supporting physicians in their decisions. Meantime, system errors are the most critical concerns in designing decision support systems that can affect their performance and efficacy. A well-developed ontology can be helpful in this matter. The proposed systematic review will specify the methods, components, language of rules, and evaluation methods of current ontology-driven guideline-based clinical decision support systems.

Methods
This review will identify literature through searching MEDLINE (via Ovid), PubMed, EMBASE, Cochrane Library, CINAHL, ScienceDirect, IEEEXplore, and ACM Digital Library. Gray literature, reference lists, and citing articles of the included studies will be searched. The quality of the included studies will be assessed by the mixed methods appraisal tool (MMAT-version 2018). At least two independent reviewers will perform the screening, quality assessment, and data extraction. A third reviewer will resolve any disagreements. Proper data analysis will be performed based on the type of system and ontology engineering evaluation data.

Discussion
The study will provide evidence regarding applying ontologies in guideline-based clinical decision support systems. The findings of this systematic review will be a guide for decision support system designers and developers, technologists, system providers, policymakers, and stakeholders. Ontology builders can use the information in this review to build well-structured ontologies for personalized medicine.

Systematic review registration
PROSPERO CRD42018106501
Strain-level profiling with picodroplet microfluidic cultivation reveals host-specific adaption of honeybee gut symbionts
Authors: Meng Yujie , Li Shuang , Zhang Chong , Zheng Hao 
Published: August 2022

AbstractBackgroundSymbiotic gut microbes have a rich genomic and metabolic pool and are closely related to hosts’ health. Traditional sequencing profiling masks the genomic and phenotypic diversity among strains from the same species. Innovative droplet-based microfluidic cultivation may help to elucidate the inter-strain interactions. A limited number of bacterial phylotypes colonize the honeybee gut, while individual strains possess unique genomic potential and critical capabilities, which provides a particularly good model for strain-level analyses.ResultsHere, we construct a droplet-based microfluidic platform and generated ~ 6 × 108droplets encapsulated with individual bacterial cells from the honeybee gut and cultivate in different media. Shotgun metagenomic analysis reveals significant changes in community structure after droplet-based cultivation, with certain species showing higher strain-level diversity than in gut samples. We obtain metagenome-assembled genomes, and comparative analysis reveal a potential novel cluster fromBifidobacteriumin the honeybee. Interestingly,Lactobacillus panisapiumstrains obtained via droplet cultivation fromApis melliferacontain a unique set of genes encodingl-arabinofuranosidase, which is likely important for the survival of bacteria in competitive environments.ConclusionsBy encapsulating single bacteria cells inside microfluidic droplets, we exclude potential interspecific competition for the enrichment of rare strains by shotgun sequencing at high resolution. The comparative genomic analysis reveals underlying mechanisms for host-specific adaptations, providing intriguing insights into microbe-microbe interactions. The current approach may facilitate the hunting for elusive bacteria and paves the way for large-scale studies of more complex animal microbial communities.
Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Authors: Delgado-Diaz David Jose , Jesaveluk Brianna , Hayward Joshua A. , Tyssen David , Alisoltani Arghavan , Potgieter Matthys , Bell Liam , Ross Elizabeth , Iranzadeh Arash , Allali Imane , Dabee Smritee , Barnabas Shaun , Gamieldien Hoyam , Blackburn Jonathan M. , Mulder Nicola , Smith Steven B. , Edwards Vonetta L. , Burgener Adam D. , Bekker Linda-Gail , Ravel Jacques , Passmore Jo-Ann S. , Masson Lindi , Hearps Anna C. , Tachedjian Gilda 
Published: August 2022

Abstract
Background
Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections including HIV, but the biological mechanisms involved remain poorly defined. Here, we performed metaproteomics on vaginal swab samples from young South African women (n = 113) and transcriptomics analysis of cervicovaginal epithelial cell cultures to examine the ability of lactic acid, a metabolite produced by cervicovaginal lactobacilli, to modulate genital epithelial barrier function.

Results
Compared to women with Lactobacillus-depleted microbiota, women dominated by vaginal lactobacilli exhibit higher abundance of bacterial lactate dehydrogenase, a key enzyme responsible for lactic acid production, which is independently associated with an increased abundance of epithelial barrier proteins. Physiological concentrations of lactic acid enhance epithelial cell culture barrier integrity and increase intercellular junctional molecule expression.

Conclusions
These findings reveal a novel ability of vaginal lactic acid to enhance genital epithelial barrier integrity that may help prevent invasion by sexually transmitted pathogens.
Extra benefit of microalgae in raw piggery wastewater treatment: pathogen reduction
Authors: Lee Sang-Ah , Kim Minsik , Kim Hee-Sik , Ahn Chi-Yong 
Published: August 2022

Abstract
Background
Monitoring microbial communities especially focused on pathogens in newly developed wastewater treatment systems is recommended for public health. Thus, we investigated the microbial community shift in a pilot-scale microalgal treatment system for piggery wastewater.

Results
Microalgae showed reasonable removal efficiencies for COD and ammonia, resulting in higher transparency of the final effluent. Metagenome and microbial diversity analyses showed that heterotrophic microalgal cultivation barely changed the bacterial community; however, the mixotrophic microalgal cultivation induced a sudden change. In addition, an evaluation of risk groups (RGs) of bacteria showed that raw piggery wastewater included abundant pathogens, and the microalgal treatment of the raw piggery wastewater decreased the RG2 pathogens by 63%. However, co-cultivation of microalgae and the most dominant RG2 pathogen, Oligella, showed no direct effects between them.

Conclusions
Thus, a microbial interaction network was constructed to elucidate algae-bacteria interrelationships, and the decrease in Oligella was indirectly connected with microalgal growth via Brevundimonas, Sphingopyxis, and Stenotrophomonas. In a validation test, 3 among 4 connecting bacterial strains exhibited inhibition zones against Oligella. Therefore, we showed that microalgal wastewater treatment causes a decrease in RG2 bacteria, which is an indirect impact of microalgae associated with bacteria.

Graphical Abstract
A review of experimental evidence of how communication affects attitudes to immigration
Authors: Dennison James 
Published: August 2022

AbstractThe need for strategic communication in migration policymaking is increasingly widely recognised. Whereas until recently there was relatively little academic evidence of what forms of immigration communication are effective, the past few years have seen a large amount of new experimental evidence. This article overviews 68 experimental studies, as well as other relevant studies, categorising their findings into nine common communication strategies. Appealing to common interest rather than self-interest, appealing to conformity rather than diversity, migrant descriptions, appealing to common ground, and appealing to empathy are consistently shown to be effective. Fact-checking of the effects of migration and appealing to emotions are mostly shown to be effective, as is appealing to identity where applicable. By contrast, appealing to diversity is consistently shown to be ineffective, while correcting information about migrant stocks and appeals to self-interest are mostly shown to be ineffective. Overall, this review article supports psychological findings regarding attitudinal formation that emphasise sociotropic considerations of the effects of immigration, economic or otherwise, on the collective while offering weaker support for egocentric approaches.
Effect of Resistance Exercise Orders on Health Parameters in Trained Older Women: A Randomized Crossover Trial
Authors: CUNHA PAOLO M. , NUNES JOÃO PEDRO , WERNECK ANDRÉ O. , RIBEIRO ALEX S. , da Silva Machado DANIEL GOMES , KASSIANO WITALO , COSTA BRUNA D. V. , CYRINO LETÍCIA T. , ANTUNES MELISSA , KUNEVALIKI GABRIEL , TOMELERI CRISIELI M. , FERNANDES RODRIGO R. , JUNIOR PAULO SUGIHARA , TEIXEIRA DENILSON C. , VENTURINI DANIELLE , BARBOSA DÉCIO S. , QIAN YU , HEROLD FABIAN , ZOU LIYE , MAYHEW JERRY L. , STUBBS BRENDON , CYRINO EDILSON SERPELONI 
Published: August 2022

ABSTRACT

Purpose
This study aimed to compare the effects of four resistance exercise orders on muscular strength, body composition, functional fitness, cardiovascular risk factors, and mental health parameters in trained older women.

Methods
The intervention lasted 63 wk. Sixty-one physically independent women (>60 yr) after completing a 12-wk resistance training (RT) preconditioning phase were randomized into four different exercise orders groups to perform 12 wk of RT: multijoint to single-joint and upper- to lower-body, single-joint to multijoint and upper- to lower-body, multijoint to single-joint and lower- to upper-body, and single-joint to multijoint and lower- to upper-body. This was followed by a 12-wk detraining period and another 12-wk RT in which exercise orders were crossed over between MJ-SJ and SJ-MJ conditions. Body composition (dual-energy x-ray absorptiometry), muscular strength (one-repetition maximum tests), functional fitness (gait speed, walking agility, 30-s chair stand, and 6-min walk tests), cardiovascular risk factors (glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, C-reactive protein, advanced oxidation protein product, total radical-trapping antioxidant parameter, and nitric oxide), depressive (Geriatric Depression Scale) and anxiety symptoms (Beck Anxiety Inventory), and cognitive performance (Montreal Cognitive Assessment, Trail Making, verbal fluency, and Stroop test) were analyzed.

Results
After the final training period, all groups presented significant improvements (P < 0.05) in almost all analyzed variables (muscular strength, body composition, functional tests, blood biomarkers, and mental health parameters), without significant difference among exercise orders.

Conclusions
Our results suggest that RT exercise orders in which MJ, SJ, upper, or lower-body exercises are performed first have similar effects on health parameters in trained older women.
Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss
Authors: Yao Huizhen , Ji Yimei , Zhou Yanru 
Published: August 2022

Objectives: Changes in coagulation indexes, thromboelastogram(TEG) and autoantibodies in patients with recurrent pregnancy loss (RPL) with different number of abortions were analyzed.
Methods: Medical records of 48 patients with recurrent abortion, treated in Quzhou people’s Hospital from November 2019 to October 2020, were collected as the observation group. Based on the number of abortions, patients were divided into Group-A (Two abortions, n=21), Group-B (Three abortions, n=16) and group C (Abortion ≥ four times, n=11). Records of 50 healthy pregnant women in our hospital in the same period were selected as the control group. Coagulation indexes [prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB), D-Dimer (DD)], thromboelastogram (TEG) parameters [reaction time (R), coagulation time(K), maximum thrombus amplitude (MA), coagulation angle (α)], changes in the levels of autoantibodies [anticardiolipin antibody (ACA), anti-endometrial antibody (EmAb), anti-thyroid antibody(ATA)] were compared between the groups.
Results: There were significant differences in the levels of ATPP, Pt, FIB and DD among the groups. Higher number of abortions correlated with lower the levels of ATPP and Pt, and higher levels of FIB and DD (P<0.05). Compared to the control group, R and K in Group-A,B and C decreased, while α and MA increased (P<0.05). There were significant differences in α and MA indexes. The positive rates of ACA, EmAb and ATA in Group-A were higher than those in the control group, but the difference was not statistically significant (P>0.05), while the above indexes in groups B and C were significantly higher than those in the control group(P<0.05). The positive rates of ACA and ATA in group C were significantly higher than those in Group-A(P<0.05), but there was no significant difference in the positive rate of EmAb (P>0.05).
Conclusion: RPL was related to the decrease of APTT, PT, and the increase of FIB and DD levels. TEG indicated that the increase of α and MA values indicated that the risk of multiple abortion was increased. The positive rates of ACA, EmAb and ATA were closely related to multiple abortions, especially the positive rates of ACA and ATA.
doi: https://doi.org/10.12669/pjms.38.7.6284
How to cite this:Yao H, Ji Y, Zhou Y. Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss. Pak J Med Sci. 2022;38(7):2005-2010. doi: https://doi.org/10.12669/pjms.38.7.6284
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Inflammatory markers in patients who presented with acute coronary syndrome and history of COVID-19 infection: a cross-sectional study
Authors: Sadeq Awfa , Al Saffar Hilal , Alabdali Samara 
Published: August 2022

Background: During the COVID-19 outbreak, the number of patients who have developed acute coronary syndromes (ACS) has soared rapidly, cardiovascular disease and mortality are influenced by the elevated inflammatory biomarkers. The aim of this study is to compare inflammatory markers between patients with ACS who hadn’t previously had COVID-19 and those who’d be infected within the preceding three months; as well as, evaluating the effect of statins on inflammatory biomarkers. Methods: This is a comparative cross-sectional study of 42 patients who presented with ACS and had previously had COVID-19 and 48 patient who had never had COVID-19, who were admitted to the coronary care unit at the Iraqi Center for Heart Disease and Baghdad Teaching Hospital, Iraq. Inflammatory biomarkers (TNF-α, IL-6, and HS-CRP) levels were determined in serum samples of all patients at admission to these centers then one month later, after administration of statins daily using the Sandwich-ELISA Principle, and Immunofluorescence technique for these markers. Result: The baseline for patients who had ACS and COVID-19 three months previously, were IL6 (85.87 ±45.80), HS-CRP (23.19 ± 14.49), and TNF-α (161.94± 240.96) were higher than patients that had ACS but not COVID-19; IL6 (50.77±22.48), HS-CRP (13.64± 12.09), and TNF-α (117.73 ±71.23),(p<0.0001), (p=0.003) and (p=0.201) for IL6, HS-CRP, and TNF-α respectively. Rosuvastatin showed a significant reduction in HS-CRP and IL6 (P<0.001), while Atorvastatin a significant reduction in HS-CRP (P<0.001) after one month of therapy. Yet there was no significant difference in the level of TNF α in these two groups at the end of this study. Conclusions: The patients with previous COVID-19 still had higher inflammatory markers than those who didn’t. Rosuvastatin 40mg had a more reduction in IL6 than Atorvastatin 40mg after one month and both of them could reduce HS-CRP, but neither could reduce TNF-α in this short period.
Pregnancy-induced rhinitis: nose problems at the obstetrician's office
Authors: Standyło Arkadiusz , Obuchowska Aleksandra , Obuchowska Karolina , Gorczyca Kamila , Kimber-Trojnar Żaneta , Leszczyńska-Gorzelak Bożena 
Published: August 2022

Introduction and purpose
Pregnancy-induced rhinitis (PIR) manifests as nasal congestion, with resolution of symptoms after delivery. Pregnancy-induced rhinitis is a distinct condition from allergic rhinitis, it may not respond to treatment for allergic rhinitis. The first stage in providing adequate and effective management of PIR is to have a clear and appropriate diagnosis. Therefore, each patient-specific management of PIR must take careful consideration of a variety of circumstances.
The aim of this study was to conduct a literature review on pregnancy-induced rhinitis. A literature review was carried out in the PubMed, MEDLINE, and Scopus databases using the terms ‘rhinitis and pregnancy’.
Brief description of the state of knowledge
Physiological factors underlying PIR are not well understood at the moment. There is no single explanation for the pathophysiological mechanism that would account for the changes in PIR. Nasal congestion is the primary nasal symptom in pregnancy-induced rhinitis. It can result in night-time mouth breathing and poor sleep quality. The mother's sleep may be negatively impacted by nasal congestion resulting in maternal hypertension, pre-eclampsia, and intrauterine growth retardation. Increasing awareness not only benefits pregnant patients' quality of life but also has a favourable impact on how a pregnancy turns out.
Summary
PIR has gained relevance in recent years due to its major effects on maternal quality of life as well as the identification of a relationship with OSAS in the mother and potential harmful consequences on the foetus. The mother's quality of life is significantly impacted by PIR, as shown, thus both the otorhinolaryngologist and the obstetrician must use caution in the early identification and treatment of pregnancy-induced rhinitis.
O LIVRO QUARTO DE DESPEJO DE CAROLINA MARIA DE JESUS EM SALA DE AULA: OLHARES PARA AS MULHERES NEGRAS NA SOCIEDADE BRASILEIRA
Authors: Amorim Roseane Maria de , Wanderley Alba Cleide Calado , Costa Luciélio Marinho da 
Published: August 2022

Trata-se de um artigo em formato de relato de experiência sobre o uso do livro Quarto de despejo de Carolina Maria de Jesus e sobre as discussões voltadas às mulheres negras que compõem a História, invisibilizadas nos currículos da educação básica e do ensino superior. Explicita-se que as histórias das mulheres negras estudadas em sala de aula foram reinterpretadas através de manifestações artísticas. Objetiva-se apresentar aos discentes em formação, caminhos que permitam novos olhares para o currículo e para a prática docente. Compreende-se que as vivências de formação precisam questionar o modelo educativo atual, uma vez que este não mais atende às demandas de uma sociedade que vive em constante transformação, permeada por conflitos diversos.
MULHERES NA FÍSICA
Authors: Farias Maria Silva 
Published: August 2022

O presente trabalho que versa sobre a visibilidade de mulheres nas ciências, em especial na Física, nos trará três grandes nomes: Emmy Noether, Marie Curie e Mária Telkes. No qual discorremos sobre alguns fatos históricos sobre a vida e descoberta destas mulheres na sociedade, buscando trazer as dificuldades enfrentadas, importância de suas pesquisas e alguns trabalhos de destaque. As contribuições delas foram ponto de partida para inúmeras outras descobertas, e toda a luta dessas mulheres foi válida e geraram contribuições significativas para a sociedade de forma mais geral. Sendo assim, o objetivo deste trabalho é destacar e mostrar por meio de aspectos históricos a importância das pesquisas dessas mulheres para a sociedade e as dificuldades enfrentadas por elas em suas respectivas épocas. E assim trazendo mais visibilidade e representação destas na sociedade, que de certa forma, parecem estar esquecidas entre nós. A metodologia deste trabalho foi do tipo Qualitativo de
OUTRAS EDUCAÇÕES E OUTRAS PRAXIS COM AS FAVELAS E PERIFERIAS URBANAS
Authors: Baptista Carlos Augusto 
Published: August 2022

Este artigo se insere no campo dos estudos culturais e perpassa apreensões das andarilhagens com coletivos periféricos que se formam inspirados no ideário da emancipação social. Nossa imersão se deu no Museu da Maré entre 2018 e 2020, acompanhando lideranças de grande destaque e as ações propostas na dinâmica organizacional. Devido ao alto índice de violência existente em contextos sociais urbanos, periféricos e, até mesmo, semi-rurais, como é o caso de favelas e bairros favelizados da zona oeste, e entorno, a ênfase do argumento central tem a ver com os contornos da politização nas periferias urbanas a partir das linguagens midiáticas e estéticas. Consideramos que com o acúmulo de pesquisas acadêmicas, sobre as diferentes temáticas que emergem das favelas da cidade do Rio de Janeiro, é possível se aproximar de noções e conceitos específicos, diferenciados dos legitimados socialmente e fomentar outros percurso investigativos sobre esse temário. Sobre as questões que atravessam a realidade cotidiana de moradores de favelas, destacamos a organicidade com capilaridade irreparável, na atualidade. Nessa mesma esteira, exploramos argumentações próximas de um compromisso-ético com sujeitas/os do território indo além das perspectivas hegemônicas sobre formação e consequentemente, processos de politização. Palavras chave: Outras educações; juventudes racializadas; Periferias urbanas ResumenEste artículo se enmarca en el campo de los estudios culturales y recorre aprehensiones de deambular con colectivos periféricos que se forman inspirados en los ideales de emancipación social. Nuestra inmersión tuvo lugar en el Museo de la Maré entre 2018 y 2020, siguiendo a los líderes destacados y las acciones propuestas en la dinámica organizativa. Debido al alto índice de violencia existente en contextos sociales urbanos, periféricos e incluso semirrurales, como los barrios marginales de la zona oeste y alrededores, el énfasis del argumento central tiene que ver con los contornos de la politización en la zona urbana. A partir de los lenguajes mediático y estéticos. Creemos que con la acumulación de investigaciones académicas sobre las diferentes temáticas que emergen de las favelas de la ciudad de Río de Janeiro, es posible abordar nociones y conceptos específicos, distintos a los socialmente legitimados, y propiciar otros caminos investigativos. sobre este tema. Sobre los temas que atraviesan la realidad cotidiana de los faveleros, destacamos la organicidad con irreparable capilaridad, en la actualidad. En la misma línea, exploramos argumentos cercanos a un compromiso ético con los sujetos del territorio, superando las perspectivas hegemónicas sobre la formación y, en consecuencia, los procesos de politización.Palavras chave: Otras educaciones; juventudes racializadas; Periferías urbanas