bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusive LGBTQ+ fieldwork: Advancing spaces of belonging and safety
Authors: Zebracki Martin , Greatrick Aydan 
Published: August 2022

AbstractIncreasing everyday levels of LGBTQ+ phobia and other forms of identity‐based prejudice reveal the need for systematic attention across the versatile geographic discipline to the belonging and safety of LGBTQ+ field researchers. Through an expanded reflection on Bracken and Mawdsley's (2004) account ‘“Muddy glee”: Rounding out the picture of women and physical geography fieldwork’ (Area, 36, pp. 280–286), we consider the major issues – including forms of discrimination, exclusion and, sometimes, violence – that LGBTQ+ researchers (and more widely fieldworkers engaging LGBTQ+ communities) encounter at different stages of field research. We pursue a critical dialogue with opportunities and limitations provided by field, disciplinary as well as home institutional contexts and practices, including ethics and risk assessments, codes of conduct and support levels (or rather their deficiencies).
Comprehensive proteomic analysis reveals dynamic phospho‐profiling in human early erythropoiesis
Authors: Peng Yuanliang , Tang Li , Li Yanan , Song Jianhui , Liu Hong , Wang Pan , Zhong Zhizhou , Yang Yifei , Wang Shihui , Chen Lixiang , Zhang Ji , Zhang Shijie , Wang Zi , Li Min , Liang Long , Liu Jing 
Published: August 2022

SummaryNormal early erythropoiesis depends on the precise regulation of protein expression and phosphorylation modification. Dysregulation of protein levels or modification contributes to erythroid disorders. To date, the dynamics of protein phosphorylation profiling across human erythroid development is not fully understood. Here, we characterized quantitative proteomic and phosphoproteomic profiling by tandem mass‐tagging technology. We systemically built phospho‐expression profiling and expression clusters of 11 414 phosphopeptides for human early erythropoiesis. The standardization methods for multitier integrative analyses revealed multiple functional modules of phosphoproteins (e.g., regulation of the G2/M transition) and active phosphorylated signalling (e.g., cell cycle‐related pathways). Our further analysis revealed that CDK family members were the main kinases that phosphorylate substrates in erythroid progenitors and identified that CDK9 played an important role in the proliferation of erythroid progenitors. Collectively, our phosphoproteomic profiling, integrative network analysis and functional studies define landscapes of the phosphoproteome and reveal signalling pathways that are involved in human early erythropoiesis. This study will serve as a valuable resource for further investigations of phosphatase and kinase functions in human erythropoiesis and erythroid‐related diseases.
Use of thyroid hormones in hypothyroid and euthyroid patients: A THESIS questionnaire survey of UK endocrinologists
Authors: Younes Younes R. , Perros Petros , Hegedüs Laszlo , Papini Enrico , Nagy Endre V. , Attanasio Roberto , Negro Roberto , Field Benjamin C. T. 
Published: August 2022

AbstractObjectiveManagement of hypothyroidism is controversial because of medication cost pressures and scientific uncertainty on how to address treatment dissatisfaction experienced by some patients. The objective was to investigate the experience and preferences of UK endocrinologists in use of thyroid hormones.DesignWeb‐based survey.PatientsUK endocrinologists were invited to participate.MeasurementsResponses to questionnaire.ResultsThe response rate was 21% (272/1295). While levothyroxine monotherapy is regarded as the treatment of choice for hypothyroidism, 51% of respondents stated that combined treatment with levothyroxine and liothyronine could be considered for levothyroxine‐treated patients whose symptoms persist despite normalisation of serum thyroid stimulating hormone (TSH) concentration. However, only 40% are currently prescribing such treatment, and just 23% would consider taking it themselves. A small minority prescribe desiccated thyroid extract, and those most likely to do so are aged over 60 years. Most respondents stated that they have no influence over brand or formulation of levothyroxine dispensed to their patients and expect no major differences in efficacy between different formulations. A total of 9% would prescribe levothyroxine for euthyroid enlarging goitre, and 29% for euthyroid female infertility with high titre thyroid peroxidase antibodies, despite recent trials finding no benefit.ConclusionsUK endocrine practice in management of hypothyroidism is broadly in line with international guidance. However, a minority of respondents would consider thyroid hormone supplementation in euthyroid individuals for female infertility, enlarging goitre, and other indications in which evidence of efficacy is lacking. Willingness to consider prescribing combined levothyroxine and liothyronine, for hypothyroid symptoms which persist despite normalised TSH, has increased in comparison to previous international surveys, despite inconsistent evidence of benefit.
Telemedicine and delivery of ophthalmic care in rural and remote communities: Drawing from Australian experience
Authors: Kiburg Katerina V. , Turner Angus , He Mingguang 
Published: August 2022

AbstractRural and remote communities in Australia are characterised by small but widely dispersed populations. This has been proven to be a major hurdle in access to medical care services with screening and treatment goals repeatedly being missed. Telemedicine in ophthalmology provides the opportunity to increase the availability of high quality and timely access to healthcare within. Recent years has also seen the introduction of artificial intelligence (AI) in ophthalmology, particularly in the screening of diseases. AI will hopefully increase the number of appropriate referrals, reduce travel time for patients and ensure timely triage given the low number of qualified optometrists and ophthalmologists. Telemedicine and AI has been introduced in a number of countries and has led to tremendous benefits and advantages when compared to standard practices. This paper summarises current practices in telemedicine and AI and the future of this technology in improving patient care in the field of ophthalmology.
A Heterotopology of Urban Margins: Publicness in the Space of the City
Authors: Wallace Yvonne , Stalcup Meg 
Published: August 2022

AbstractUrban marginality is generally considered through the lens of exclusion. Policing and public policies, underpinned by private NIMBY (not‐in‐my‐backyard) attitudes and actions, aim to remove marginalized individuals from urban spaces. Yet they remain and are visible. As such, individuals across the urban margins share in publicness, which is the connection between strangers unique to cities borne from their visibility to one another. We suggest that publicness provides the terrain for an impactful mode of urban study, one which attends to the transitory encounters that anthropology has traditionally tried to transform and thicken. The ways in which individuals perform when they are visible in public displays something of how they understand themselves in relation to others, a form of mutual subjectification in which we as researchers are also implicated. Drawing on fieldwork in Ottawa, Ontario, with individuals who use drugs and individuals who panhandle, we analyze urban margins as other spaces and publicness as other relations using Foucault’s concept of heterotopia. This resulting heterotopology shows a different version of marginality in the city in which urban margins are not separate from but connected to the urban experience.
Two parallel chromosome‐level reference genomes to support restoration and aquaculture of European flat oyster Ostrea edulis
Authors: Bean Tim P. , Tanguy Arnaud , Peñaloza Carolina , Gundappa Manu Kumar , Boutet Isabelle , Houston Ross D. , Macqueen Daniel J. , Boudry Pierre 
Published: August 2022

AbstractThis volume of Evolutionary Applications sees the publication of two genomes for the European native flat oyster Ostrea edulis, a species of significant evolutionary, ecological and commercial value. Each is a highly contiguous chromosome‐level assembly from individuals of different genetic backgrounds, which have been benchmarked against one another. This situation has resulted from the serendipitous discovery that two independent research groups were both deep into the process of building, annotating and investigating separately produced assemblies. Due to constraints with funder requirements and the need to recognize early career researchers for their work, alongside the technical challenge of integrating assemblies from two very different genomes, there was limited capacity to merge the sequences into one publication at the stage of discovery. This issue is likely to become very common over the next few years until the technologies for working with multiple genomes at once, for example, graph genomes, become commonplace in nonmodel species. Consequently, both of our teams have decided to collaborate rather than compete, recognizing the benefit to copublishing two separate genome resources for the research community, each with distinct scientific investigations, and working collaboratively to benchmark the assemblies.
‘KEINE ZEIT ZU VERLIEREN’: TIME AND CARE IN INGEBORG BACHMANN'S ‘DAS GEBELL’ AND DAS BUCH FRANZA
Authors: Jeremiah Emily 
Published: August 2022

AbstractThis article explores the handling of time and care in two works by Ingeborg Bachmann: the short story ‘Das Gebell’ and the uncompleted novel Das Buch Franza. It argues that care and time are linked in the works, in a manner that echoes the thinking of Lisa Baraitser (Enduring Time). ‘Das Gebell’ offers a critique of masculinist models of time and puts forward a feminist ethics of care. Das Buch Franza points up the difficulty and ambivalence involved in care, as it traces the complex dynamic between a brother and a sister. Both texts explore the fascism that lurks beneath heterosexual relationships, in line with Karen R. Achberger's view that one theme runs throughout Bachmann's works: ‘the constant state of war’. This war is gendered in complex ways. Through her works, Bachmann complicates and enhances theories of submission and domination such as that developed by Jessica Benjamin (The Bonds of Love), the texts themselves forming sites of protest and transformation.
A patient with femoral artery pseudoaneurysm treated with ultrasound‐guided injection of an exogenous lyophilized human fibrin sealant
Authors: Gao Xuejing , Xiong Ying , Wan Ziming 
Published: August 2022

AbstractA femoral artery pseudoaneurysm (FAP) is a serious complication of arterial injury. It can cause compression of the surrounding nerves and tissues, rupture and bleeding of the aneurysm, and formation and dislodgement of thrombi, and can lead to distal limb embolism, tissue necrosis, and infection. Computed tomography angiography and ultrasonography are the preferred techniques for diagnosis of FAP. This report describes the successful treatment of an FAP using an ultrasound‐guided percutaneous intracavitary injection of a lyophilized human fibrin sealant. This treatment was safe, associated with minimal pain and complications, and clinically effective.
Secretory carcinoma of the salivary gland: a multi‐institutional clinicopathologic study of 90 cases with emphasis on grading and prognostic factors
Authors: Xu Bin , Viswanathan Kartik , Umrau Kavita , Al‐Ameri Thair A. D. , Dogan Snjezana , Magliocca Kelly , Ghossein Ronald A. , Cipriani Nicole A. , Katabi Nora 
Published: August 2022

BackgroundSecretory carcinoma (SC) is a rare form of salivary carcinoma that was first described in 2010 and is characterized by ETV6::NTRK3 fusion in most cases. In this large retrospective study, we aimed to identify adverse clinicopathologic factors and propose a prognostically relevant grading scheme for SC.MethodsA detailed clinicopathologic review was conducted on 90 SCs from the major and minor salivary glands.ResultsThe median age at presentation was 50 years (range: 7–93). Sixty‐nine (77%) tumours originated from major salivary glands, whereas the remaining 21 involved minor salivary glands.Six cases (7%) had cervical nodal metastasis. Only lymphovascular invasion (LVI) was associated with a risk of nodal metastasis (P < 0.05). The 5‐year disease‐specific survival and disease‐free survival (DFS) were 98% and 87%, respectively. On univariate survival analysis, adverse prognostic factors associated with decreased DFS included minor salivary gland origin, atypical mitosis, high mitotic index, high‐grade transformation (HGT), necrosis, nuclear pleomorphism, infiltrative tumour border, fibrosis at the invasive front, LVI, positive margin, and advanced pT stage (P < 0.05). When adjusted for pT stage and margin status, mitotic index, LVI, nuclear pleomorphism, and HGT remained as independent prognostic factors.ConclusionWe therefore propose a two‐tiered grading system for SC. The low‐grade SC is defined as those with <5 mitoses /10 high‐power fields and no tumour necrosis, and high‐grade SC as those with ≥5 mitoses /10 high‐power fields and/or necrosis. This proposed grading system can be useful to risk stratify patients with SC for appropriate clinical management.
Bictegravir/emtricitabine/tenofovir alafenamide in patients with genotypic NRTI resistance
Authors: Shafran Stephen D. , Hughes Christine A. 
Published: August 2022

AbstractBackgroundBictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) is approved for treatment of HIV without known resistance to its components. Several studies have demonstrated efficacy of B/F/TAF in patients with nucleoside reverse transcriptase inhibitor (NRTI) resistance‐associated mutations (RAMs), mainly identified by proviral DNA testing, but data on the efficacy of B/F/TAF in patients with NRTI RAMs identified in viraemic plasma are limited.MethodsWe used a retrospective analysis of patients receiving B/F/TAF identified by searching electronic health records with eligibility confirmed by review of individual patient records. Patients included were ≥ 18 years, had 2019 International Antiviral Socitey‐USA (IAS‐USA) major RAMs affecting NRTIs detected in viraemic plasma prior to starting B/F/TAF and one or more HIV viral load (VL) after starting B/F/TAF.ResultsIn all, 50 patients met the study criteria: mean age of 54 years, mean proximal CD4 count of 609 cells/μL, 64% male. A total of 46 were virologically suppressed (< 200 copies/mL) when B/F/TAF was initiated, two were treatment‐naïve, one stopped prior antiretroviral therapy (ART) and one had a VL of 961 HIV‐1 RNA copies/mL on ART. Twenty‐nine had one NRTI RAM (24 were M184V/I), nine had two NRTI RAMs, three had three NRTI RAMs, four had four NRTI RAMs, two had five NRTI RAMs, one had six NRTI RAMs, one had seven RAMs and one had eight NRTI RAMs. At the last VL on B/F/TAF, a mean of 18.6 months after starting B/F/TAF, 49 out of 50 had VL < 100 copies/mL and one had a VL of 208 copies/mL at 11 months but only filled 5 months of B/F/TAF.ConclusionsB/F/TAF was effective in maintaining HIV VL suppression in patients with previously documented NRTI RAMs without integrase resistance.
Early‐life exposure to tobacco and childhood adiposity: Identifying windows of susceptibility
Authors: Moore Brianna F. , Kreitner Kimberly J. , Starling Anne P. , Martenies Sheena E. , Magzamen Sheryl , Clark Maggie , Dabelea Dana 
Published: August 2022

SummaryBackgroundEarly‐life exposure to tobacco is associated with obesity, but the most susceptible developmental periods are unknown.ObjectiveTo explore windows of susceptibility in a cohort of 568 mother–child pairs.MethodsWe measured seven measures of tobacco exposure (five self‐reported and two biomarkers) spanning from pre‐conception to age 5 years. Mothers self‐reported active smoking (pre‐conception, 17 weeks, and delivery) and household smokers (5 and 18 months postnatally). Cotinine was measured in maternal urine (27 weeks) and child urine (5 years). Adiposity (fat mass percentage) was measured at birth and 5 years via air displacement plethysmography. Using a multiple informant approach, we tested whether adiposity (5 years) and changes in adiposity (from birth to 5 years) differed by the seven measures of tobacco exposure.ResultsThe associations may depend on timing. For example, only pre‐conception (β = 3.1%; 95% CI: 1.0–5.1) and late gestation (β = 4.0%; 95% CI: 0.4–7.6) exposures influenced adiposity accretion from birth to 5 years (p for interaction = 0.01). Early infancy exposure was also associated with 1.7% higher adiposity at 5 years (95% CI: 0.1–3.2). Mid‐pregnancy and early childhood exposures did not influence adiposity.ConclusionsPre‐conception, late gestation, and early infancy exposures to tobacco may have the greatest impact on childhood adiposity.
Effect of technological and digital learning resources on students' soft skills within remote learning: The mediating role of perceived efficacy
Authors: Lousã Eva P. , Lousã Mário D. 
Published: August 2022

AbstractThe study analyses the effects of the technological and digital learning resources (DLRs) on the development of students' soft skills (SSk) in remote learning, mediated by the perceived efficacy of students in this modality of education. The study employed a survey research method, and the data were collected through a self‐administered questionnaire. Participants included 637 students experiencing remote learning during the second COVID‐19 lockdown in the north of Portugal (between 1 and 15 March 2021). The structural equation modelling analysis technique tested the hypothesized model. The study showed that technological and DLRs were strongly interconnected. The results supported our hypotheses, evidencing that, in remote learning, the adequacy of DLRs had a direct effect on the development of SSk, presenting the efficacy perceived by the students as a mediator of this relationship. The study demonstrated that, with the experience of remote learning, students perceived the development of their SSk, which is consistent with the literature review we carried out. Implications of these findings are discussed, considering the literature on technology‐mediated learning and the development of human resources SSk in the context of the digital transition.
Clinicopathological features of adrenal malignancies: Analysis of hospital‐based cancer registry data in Japan
Authors: Chihara Ichiro , Nagumo Yoshiyuki , Kandori Shuya , Kojo Kosuke , Sano Keisuke , Hamada Kazuki , Tanuma Kozaburo , Tsuchiya Haruki , Shiga Masanobu , Sakka Shotaro , Kimura Tomokazu , Kawahara Takashi , Hoshi Akio , Negoro Hiromitsu , Kojima Takahiro , Bryan Mathis J , Okuyama Ayako , Higashi Takahiro , Nishiyama Hiroyuki 
Published: August 2022

ObjectiveTo identify the clinicopathological features of adrenal malignancies and analyze the prognoses of patients with adrenal cortical carcinoma (ACC) and malignant pheochromocytoma (MPCC).Patients and methodsWe used a hospital‐based cancer registry data in Japan to extract cases of adrenal malignancies that were histologically confirmed, diagnosed, and initially treated from 2012–2015. For survival analysis, we used data from the 2008–2009 cohort to estimate 5‐year overall survival (OS) by the Kaplan–Meier method.ResultsA total of 989 adrenal malignancies were identified in the 2012–2015 cohort. The most common histologies were ACC (26.4%), diffuse large B‐cell lymphoma (DLBCL; 25.4%), neuroblastoma (22.2%), and MPCC (11.9%). While most ACC and MPCC patients were in their 60s, DLBCL patients accounted for 61.5% of adrenal malignancies in the over‐70 cohort. Among ACC patients with clinical staging data, 46.3% of patients were stage IV. Although surgery was a chief strategy for all stages, younger patients tended to receive combination therapy, including surgery and chemotherapy or hormone therapy. In the 2008–2009 cohort, the 5‐year OS rates of ACC (n = 49) and MPCC (n = 23) patients were 56.2% and 86.4% while ACC patients without surgery had 1‐ and 2‐year OS rates of 25.0% and 12.5%.ConclusionIn Japan, DLBCL accounted for the majority of adrenal malignancies in older patients. Despite advanced staging, ACC patients were mainly treated with surgery and their prognosis was not satisfactory. Such epidemiological data may be useful in considering initial management strategies.
User accounts on received diabetes and mental health care in a Danish setting – An interview study
Authors: Zabell Vicki , Arnfred Sidse Marie , Høgsgaard Ditte , Gæde Peter Haulund , Rønne Sabrina Trappaud , Jørgensen Rikke 
Published: August 2022

AbstractPeople with coexisting type 1 and 2 diabetes and mental illness have a higher mortality rate compared to the general population, among other reasons due to unregulated diabetes. One explanation might be the complexity of managing both conditions. In this interview study, we explored the accounts of delivered diabetes and mental health care of 16 individuals living with coexisting diabetes and mental illness in Denmark. A thematic analysis by Braun and Clarke was applied in the analysis. Some of the participants described the care for diabetes and mental illness to be inextricably linked to each other. Therefore, health care providers ought to focus and knowledge of both conditions as essential components in the care provided. The participants accounted for support needs in other settings beyond diabetes and mental health outpatient clinics, such as the family doctor, residential institutions, and community care. However, the inefficient collaboration between these health care settings is one of the barriers to supporting the participants' self‐management.
Relationships matter! Social safeness and self‐disclosure may influence the relationship between perceived social support and well‐being for in‐person and online relationships
Authors: Nguyen Lina , Phillips Cara V. , Rodriguez Amelia , Young Amber R. , Ramdass Jeff V. 
Published: August 2022

AbstractWe investigated the relationship between perceived social support and mental well‐being in in‐person and online contexts using relational regulation theory as a guiding theoretical framework. Prior research consistently finds a positive link between perceived social support and better well‐being. In our study, we investigated the relationship between perceived social support and mental well‐being in in‐person and online contexts using relational regulation theory as a guiding theoretical framework. More specifically, the present research investigates whether perceived social support and better mental well‐being are associated with increased self‐disclosure or social safeness, and whether the relationships are similar for in‐person and online contexts. Participants (Study 1: N = 268 MTurk Users; Study 2: N = 216 MTurk Users) completed measures of perceived social support, self‐disclosure, social safeness, and mental well‐being. In both correlational studies, perceived social support was positively related to well‐being. Both self‐disclosure and social safeness mediated the relationship between perceived social support and well‐being for in‐person relationships. For online relationships, a person may only need to feel socially safe to have better mental well‐being. Future research should employ experimental manipulations to expand upon these findings.