bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal glucose homeostasis in patients of HbEβ-thalassemia: Prevalence and possible pathogenesis using the Oxford HOMA model
Authors: Sen Ankita , Sahana Pranab Kumar , Chakrabarti Prantar , Ghosh Pramit , Dolai Tuphan Kanti , De Rajib 
Published: September 2022

Objectives:
Eβ-thalassemia, the most serious form of HbE syndromes, may develop pre-diabetes (PD) and diabetes mellitus (DM), together constituting abnormal glucose homeostasis (AGH) as an endocrinopathy. This study aims to assess AGH prevalence and pathogenesis in this thalassemia subtype.

Material and Methods:
A cross-sectional study was conducted at a tertiary care hospital from February 2017 to December 2018 (1.9 years). One hundred and four HbEβ-thalassemia patients were randomly selected aged ≥5 years, irrespective of transfusion requirement. AGH was diagnosed by the American Diabetes Association criteria. The patient’s history, relevant examination details, and parameters related to glucose homeostasis were studied. The homeostasis assessment (HOMA) model of Oxford University was used, and formulae were applied to calculate HOMA-insulin resistance (IR) or HOMA-β (β-cell function).

Results:
The status of glucose homeostasis was as follows: Normal glucose homeostasis tolerance 83/104(79.8%), PD 20/104(19.2%), and DM one(1%). The patient’s age, age of starting transfusions, and HOMA-IR were significantly related to AGH. AGH was inversely associated with the age of starting chelation, though not significant (P = 0.07). There was no statistical significance of AGH development, with transfusion dependence (P = 0.63), family history of DM (P = 0.42), hepatitis C (P = 0.36), and higher ferritin levels (800/1000/1500/1700 ng/ml) (P > 0.5)/HOMA-β (P > 0.5).

Conclusion:
HbEβ-thalassemia patients are prone to develop AGH including overt diabetes. It is related to the patient’s age, age of initiation, and duration of transfusion therapy. The likely mechanism of pathogenesis is IR, though pancreatic β-cell destruction may also be contributory.
Analysis of early molecular response at 3 months in predicting overall response in newly diagnosed patients with chronic myeloid leukemia on imatinib
Authors: Iqbal Asif , Nath Uttam Kumar , Bhattacharyya Maitreyee , Nag Arijit , Ray Siddhartha Sankar 
Published: September 2022

Objectives:
This study aimed to study the correlation between Breakpoint Cluster Region- ABelson Leukemia virus 1 transcript levels at 3 months with the treatment responses at 6 and 12 months in patients on imatinib. Around 30% of patients with chronic myeloid leukemia (CML) might have treatment failure with the first-line tyrosine kinase inhibitors (TKI). Patients with a “warning response” at 3 months can continue therapy with the same TKI while monitoring for disease progression. However, newer pieces of evidence suggest that patients who fail treatment with imatinib do have suboptimal responses in the early time points, and hence, 1st 3-month assessment might be a useful indicator for future treatment failure.

Material and Methods:
It is a single-center prospective observational study involving 60 treatment-naive consecutive patients with CML-chronic phase who attended Hematology Outpatient Department at IHTM, Kolkata. Treatment responses were assessed by cytogenetics and BCR-ABL1 transcript levels by real-time quantitative polymerase chain reaction at 3 monthly time points.

Results:
About 51% and 70.2% of the study participants achieved complete cytogenetic response at 6 and 12 months, respectively. About 74% of the participants had achieved early molecular response (EMR) at 3 months. The failure rates of cytogenetic responses were 13% and 20% at 6 and 12 months, respectively. Patients who failed to achieve EMR at 3 months had higher failure rates at 6 months. The major, warning and failure of molecular responses at 6 and 12 months were found to be 15%, 25%, and 9%, and 34%, 39%, and 27%, respectively. The analyses showed that patients who failed to achieve EMR at 3 months are also more likely to have the failure of molecular response at 12 months, with a statistical significance of P < 0.01. Failure of EMR at 3 months also correlated with failure of overall responses (both cytogenetic and molecular at 12 months) with a statistical significance of P = 0.006. When followed up, there was a progression of disease in three including a death in the suboptimal response group.

Conclusion:
Our patients had inferior treatment responses to imatinib than that observed in the previous studies. The majority have baseline fibrosis of the marrow and splenomegaly at presentation which might contribute to adverse outcomes. The molecular response at 3 months was found to be a consistent and powerful indicator of treatment responses at later time points.
Complications of transanal endoscopic resection in cancer recti
Authors: Nikitenko R. P. , Vorotyntseva K. O. , Degtyarenko S. P. , Stepanovichus O. M. 
Published: September 2022

Objective. To study іntra- and postoperative complications in transanal endoscopic resection in patients, suffering cancer recti and to reduce this quantity.
Materials and methods. Through the period 2009 - 2021 yrs on the base of Odessa Regional Clinical Hospital 184 patients, suffering cancer recti, were operated, using transanal endoscopic resection. The patients’ age was from 42 to 86 yrs old. The patients were distributed into two groups. In 90 patients of the first group the cancer recti diagnosis of stage I (T1-2N0M0) was established. In 94 patients of the second group the diagnosis of cancer recti stage ІІ (T3N0M0) was established.
Results. Purulent-septic, thromboembolic and urological complications were absent in all 184 patients, as well as severe intraoperative complications and mortality. The average stationary stay of the patients have constitited (3.4 ± 1.7) days (from 2 to 6 days). The average lower edge of the tumour was situated at a distance (9.5 ± 4.2) cm (from 5 to 16 cm) from the anal channell, and the average dimensions of tumour - (2.8 ± 1.7) cm (from 1.5 to 4 cm). While studying of the histological investigations results there was noted, that in all the patients the tumour was excised in the healthy tissues borders in accordance to oncological technique. Period of follow-up have constituted from 12 to 60 mo. Cancer recti recurrence was revealed in 12 (13.3%) patients of the first group. Cancer recurrence have had occur in patients, who have rejected from conduction of chemo- and radiotherapy. The patients with recurrences were reoperated, using classic low anterior rectal resection with total mesorectumectomy.
Conclusion. While conduction of preoperative neoadjuvant chemo- and radiotherapy the tumour dimensions are reduced significantly, as well as quantity of іntra- and postoperative complications in performance of transanal endoscopic resection. The disease prognosis for cancer recti depends directly on presence of metastases in regional «sentinel» lymphatic nodes.
Development of Demonstration Plots and Assistance of Farmer Group Yellow Soybean Based on Local Wisdom Supporting Food Security in Cilacap District, Central Java, Indonesia
Authors: Nuryani Hidayah Utami Sri , Harjaka Tri , Kastono Dody , Widada Jaka , Muliawan Arif , Mulyono Mulyono , Romdhon Ahmad , Prasetya Angga , Gratias Maria , Laksono Adi 
Published: September 2022

The mentoring and demonstration plot program with the application of technology carried out by the Faculty of Agriculture Universitas Gadjah Mada Team was proven to be able to increase the productivity and quality of soybeans, although some were only applied partially (not completely) from the recommended technology package, this was constrained by many factors in each mentoring area. In the Cilacap area, the demonstration plot results showed a fairly high potential reaching 2.24 tons/ha in Bantarsari, 2.94 and 3.77 tons/ha in Kawunganten, while in Majenang before harvesting soybeans showed good potential with 130-140 pods. per plant, this is of course the potential yield can reach above 3.0 tons/ha, but unfortunately it was affected by the flood due to the broken embankment, so the soybeans were inundated and damaged (rotten) in a relatively short time. The process of technology transfer and adoption that occurred went well, and many farmers gave testimony that this mentoring program was good to be developed and continued, so that under conditions according to the growing season, they would be able to show even better potential.
Understanding Preservice Teachers’ Reluctance to Use of Online Learning Platforms to Teach Individuals with Intellectual Disability
Authors: Jacob Udeme Samuel , Pillay Jace 
Published: September 2022

This study investigated the reluctance among pre-service to adopt online learning platforms to teach students with intellectual disability. This study consisted of pre-service teachers. The qualitative phenomenological research method was used to examine pre-service teachers' reluctance to adopt online learning platforms to teach students with intellectual disabilities. In-depth interviews were conducted with pre-service teachers at the Faculty of Education, University of Ibadan. Seven respondents selected using a convenient sampling technique participated in the study; respondents were referred to as Participant 1 to Participant 7 for the purpose of anonymity. Collected data were transcribed and analysed using ATLAS.ti version 22, a computer-aided qualitative data analysis software. Based on participants' responses, four major themes were generated on the perception: opportunities to access various learning platforms, no special provision for learners with intellectual disability, the possibility of learning biases, and ineffective learning methods. Based on the evidence presented here, individuals with ID will not be able to access online learning platforms to the same degree as others within society.
Increasing the Provision of Horticultural Seeds in the Women's Farmer Group "Tunas Mekar Sari" Bakas Village, Banjarangkan District, Klungkung, Bali
Authors: Yuliartini Made Sri , Ida Bagus Komang Mahardika  , Anak Agung Ngurah Mayun Wirajaya  , Anak Agung Sagung Putri Risa Andriani  
Published: September 2022

Agricultural products produced by the people of Bakas Village do not come from farmers who have been struggling with paddy fields, but with the passage of time and a change in the paradigm of the community, agricultural activities have been carried out by women who are members of a forum, namely the " Women's Farmer Group" with their activities in agriculture, namely the provision of horticultural seeds, the use of land owned by groups and yards of houses but has not been managed optimally and continuously. The Community Service (PKM) was carried out in Bakas Village, Banjarangkan District, Klungkung. This applied research aimed to improve the understanding of nursery technology in the women’s farmer group and increase the ability to provide more complete and sustainable horticultural seeds; the correct and appropriate technology of horticultural crop cultivation for the group of women’s farmers is increasing so that the results obtained increase; hydroponically as well as aquaponics (a combination of fishery and vegetable cultivation) for sustainable land use and availability The implementation of service activities to achieve goals includes providing counseling materials, training, field practices, application of technology and assistance. The external targets achieved by the partner farmer women's group can increase the income and welfare of its members through the sustainable manufacture of seeds, the improvement of sustainable food with hydroponic and aquaponic systems as well as the intensive utilization of group-owned land
Evaluation of the prevalence of caries in the second deciduous molar and adjacent first permanent molar in children of 6-12 years.
Authors: Rabia Zafar  , Muhammad Athar Khan  , Syed Jaffar Hussain Bukhari  , Asma Shakoor  , Javed Iqbal  
Published: September 2022

Objective: To evaluate the prevalence of caries in second molar deciduous molar and adjacent first permanent molar in children. Study Design: Cross Sectional study. Setting: Dental Outdoor Department of Ibn-e-Siena Hospital. Period: March 2021 to August 2021. Material & Methods: A total of 1,250 patients between the age of 6-12 years were included in the study, who were free from the other dental issues. Consent was taken from the patients and parents after explaining the procedures. Examination was done by a senior Operative dentist. For diagnosis of the caries ICDAS criteria was undertook Results: A total of 1250 children between the age of 6-12 years were included in the study. Out of these 250 children had first permanent molar caries. Boys were effected more and second deciduous molar tooth caries were associated with development of caries first permanent molars as these are closely placed. Conclusion: Association between presence of caries in primary teeth is correlated with the development of caries in the permanent teeth. So caries in the primary teeth, predicts the development of caries in the permanent teeth.
PELATIHAN OUTSEAL-HAIWELL PADA SMK MAMBAUL ULUM, GRESIK
Authors: Irawan Denny , Winarno Hendra Ari , Astutik Rini Puji , Kinanti Zizin Anggun , Prastya Eka Putra , Hidayah Alief 
Published: September 2022

Perkembangan teknologi yang sangat pesat, terkadang membuat sekolah kejuruan menjadi cepat tertinggal dalam hal penguasaan teknologi jika para guru pengajar tidak memperbaharui kemampuan mereka. Salah satu teknologi yang banyak diterapkan di industri adalah teknologi Supervisory Control And Data Acquisition (SCADA). Oleh karena itu, pengabdian ini ditujukan untuk berbagi pengetahuan teknologi SCADA untuk siswa SMK Mambaul Ulum, Gresik sebagai persiapan mereka yang akan terjun di industri. Hasil kegiatan menunjukkan bahwa terdapat peningkatan pengetahuan dan penggunaan Outseal-Haiwell yang berbasis Arduino yang berfungsi sebagai SCADA pada siswa SMK Mambaul Ulum. Hal ini dibuktikan dengan sebagian besar peserta dapat memecahkan studi kasus yang diberikan.
MENGUBAH SAMPAH BOTOL PLASTIK MENJADI SAPU SEBAGAI TAMBAHAN PENGHASILAN BAGI PETUGAS KEBERSIHAN DI DESA BANYUWANGI KECAMATAN MANYAR KABUPATEN GRESIK
Authors: Rahim Andi Rahmad , Ernawati Ernawati , Sukaris Sukaris , Maulana Mochammad Hafizh , Ramadhan Ahmad Fikri 
Published: September 2022

Di Desa Banyuwangi Kecamatan Manyar Kabupaten Gresik belum ada kegiatan bank sampah dikarenakan oleh pihak desa mempercayai salah satu warganya untuk menjadi petugas kebersihan yang juga mengelola penjualan sampah ke pengepul dan hasilnya sebagai tambahan upah kerja dari desa. Dari penjualan tersebut 1 kilogram sampah botol plastik dihargai sebesar 2.000 rupiah yang mana pendapatan tersebut bisa dikatakan hasilnya tidak seberapa banyak. Dari hasil observasi serta sharing dengan beberapa pengurus desa dan petugas kebersihan di Desa Banyuwangi, kami menyimpulkan dan memberikan solusi untuk mengadakan kegiatan daur ulang sampah botol plastik agar dapat menambah nilai jual sampah tersebut dan mencatat hasil penjualannya ke dalam jurnal akuntansi sederhana. Sasaran dari produk yang akan dijual adalah kalangan ibu rumah tangga. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk menumbuhkan jiwa wirausaha skala home industry untuk meningkatkan ekonomi keluarga masyarakat Desa Banyuwangi. Metode pengabdian dengan penyuluhan, diskusi dan tanya jawab serta praktik langsung pengolahan barang bekas menjadi barang yang bernilai ekonomis daur ulang barang bekas ini dimaksudkan dapat memberikan motivasi bagi masyarakat untuk meningkatkan kemampuannya dan berkarya sehingga mendatangkan manfaat bagi dirinya dan masyarakat sekitar.
CSR Disclosure in State Owned Enterprises in Indonesia: Does Public Share Ownership could Effect?
Authors: Merawati Luh Komang , Yuliastuti Ida Ayu Nyoman , Pradnyana I Made Adhi 
Published: September 2022

Social responsibility is one of the company's programs in the form of accountability to overcome social problems and environmental damage done by the company itself. This form of accountability can be realized by disclosing CSR. This study aims to test and obtain empirical evidence of the influence of profitability, company size, leverage, board of commissioner and public share ownership against the disclosure of CSR in state-owned enterprises.Sample used is 20 companies of state-owned enterprises in three years of observation. The data analysis technique used is multiple linear regression. The results revealed that the profitability and size of the board of commissioners had a positive effect on CSR disclosure, while the size of the company, leverage, and public share ownership had no effect on CSR disclosure. Keywords: corporate social responsibility, leverage, size, profitability, public share ownership
सक्षमता र एकीकृतताका दृष्टिले कक्षा एकको नेपाली भाषा पाठ्यक्रम (२०७६) को विश्लेषण {An Analysis of Class I Nepali Language Curriculum (2076) in terms of Competency and Integration}
Authors: Ghimire Dinesh 
Published: September 2022

प्रस्तुत लेख कक्षा एकको वर्तमान नेपाली भाषा पाठ्यव्रmमलाई थिम (विषय क्षेत्र) र भाषिक सिपगत एकीकृतता (integration) तथा सिपपगत सक्षमता (competency) का दृष्टिबाट अध्ययन गर्ने उद्देश्यले तयार पारिएको हो । यो लेख अनुसन्धानको वर्णनात्मक तरिका र पुस्तकालयीय अध्ययनमा आधारित रहेको छ । सिपगत र विषयगत एकीकृतताको सिद्धान्तमा आधारित रहेर सिपगत सक्षमतामा केन्द्रित रहेको यो पाठ्यव्रmममा अन्य देशमा प्रयोगमा आइसकेका दृष्टिकोणलाई हाम्रा परिप्रेक्ष्यमा पनि प्रयोग हुन सक्ने अपेक्षा राखी प्रचलित पाठ्यक्रमलाई प्रतिस्थापन गर्ने गरी प्रस्तुत गरिएको देखिन्छ । थिमगत र भाषिक सिपगत एकीकृतताको दृष्टिले यो पाठ्यक्रम उदाहरणीय बनेको देखिन्छ । शैक्षिक सत्र २०७६-०७७ बाट लागु गरिएको यस पाठ्यक्रमको कार्यान्वयनमा भाषिक सिपका व्यावहारिक उपयोगमा चाहिँ कठिनाइ आइपर्न सक्ने सम्भावना विद्यमान देखिन्छ । पाठ्यक्रममा उल्लेख भएका तहगत सिकाइ सक्षमता, कक्षागत सिकाइ उपलब्धि, विषय वस्तुको क्षेत्र र क्रम आदिका बिचको तालमेलमा अझ परिमार्जनको आवश्यकता महसुस हुन्छ । पाठ्यक्रममा प्रयोग भएको शब्द भण्डारका कारण यसको भाषा तह अनुरूप बन्न सकेको देखिँदैन । शिक्षण सहजीकरण प्रक्रिया, मूल्यांकन प्रक्रिया आदिका दृष्टिले भने यो पाठ्यक्रम सबल रहेको निष्कर्षमा पुगिएको छ ।
Measured and Predicted Maximal Oxygen Consumption (VO2max) in Healthy Young Adults: a Cross-Sectional Study
Authors: Buttar Karampreet Kour , Saboo Neha , Kacker Sudhanshu 
Published: September 2022

Objective: Maximal oxygen consumption (VO2max) can be estimated using maximal or sub-maximal tests, by direct or indirect methods.The Queen’s College Step Test (QCT) is used very frequently to estimate VO2max due to its simple, safe, quick and feasible approach. Originally the QCT was developed for the white race population, which is different from the Indian population in terms of ethnicity. So the present study was conducted to validate the applicability of the QCT to indirectly estimate VO2max in Indian adults. Material and Methods: A total of 419 apparently healthy students (male and female) were recruited for the study by the RUHS College of Medical Sciences (RUHS-CMS), Jaipur from January 2019 to March 2020 by random number table generator sampling. Direct estimation of VO2max was performed by sub-maximal exercise testing on a treadmill using a gas analyzer, while VO2max was indirectly predicted by the standard QCT protocol. The collected data were entered into Microsoft Excel and analyzed using unpaired student t-test, analysis of variance (ANOVA), and regression analysis.Results: The average directly measured VO2max (ml/kg/min) in males was 45.30±7.35, and for women was 35.71±5.29, and predicted by the QCT was 49.01 for males and 38.83±5.30 for females. The difference between the measured and predicted mean VO2max (PVO2max) values was statistically significant (p-value<0.05). Conclusion: In this study, actual VO2max was lower than the predicted VO2max from the QCT. The results of this study suggest that a new equation derived from the present data, recommended to assess VO2max using QCT in the Indian population, especially when large numbers of participants need to be tested in the absence of a well-equipped laboratory.
Titik Temu Pemeluk Agama dalam Presfektip Hukum Islam
Authors: Tamaruddin A 
Published: September 2022

Realita dalam kehidupan manusia di dunia, manusia diciptakan terdiri dari laki-laki dan perempuan dan ditempatkan menjadi penduduk dunia, manusia hidup berbangsa-bangsa dan bersuku-suku, serta masing-masing mempunyai budaya tersendiri. Dalam kehidupan, manusia cenderung mempunyai keyakinan dan kepercayaan. Keyakinan dan kepercayaan yang melekat pada diri manusia membuatnya leluasa memilih agama. Agama yang diyakini dan dipercayai berpotensi memberikan kebahagian dan kesejateraan hidup lahir dan batin. Hanya saja dalam kenyataan, pemeluk agama-agama pada akhirnya tidak merasakan hidup bahagia dan sejahtera, sehingga banyak yang memutuskan pindah agama, karena agama yang menjadi pilihannya diyakini keberanan dan dipercaya sebagai agama yang benar dan dapat memberi ketenangan hidup lahir dan batin. Di Indonesia, seluruh penduduk diberikan keluasan untuk memilih agama, sehingga ditemukan penganut agama yang berbeda-beda, ada penduduk yang memilih Agama Hindu, Budha, Kristen, Kong Hu Cu dan Islam. Penganut agama yang berbeda-beda yang berdiam di Indonesia memiliki kepercayaan terhadap Tuhan Yang Maha Esa. Dalam jurnal ilmiah ini, akan tergambar cara mempertemukan ajaran agama dalam perspektif hukum Islam dengan mengunakan pendekatan sosial dan filosofis dan juga sebagai cara mempertahankan titik temu penganut-penganut agama dalam bentuk kesadaran, bersikap tenggang rasa dan ketaatan kepada pemerintah.
Pengaruh Edukasi Gizi Melalui Media Booklet terhadap Perubahan Pilihan Makanan Camilan pada Remaja di Makassar
Authors: Andi Sri Rahayu Kasma  
Published: September 2022

Snacking activity has been identified as one of the potential causes of obesity and/or overweight in childhood and adolescence. According to Hampl, a child is snacking more than 15-20% of his daily calorie intake of snacks can be defined as "snacker". Snack is thought to be the promoter of obesity because it contains high fat and high sugar. This study is a quantitative research design with quasy experiment. This study was done to see if there are changes in the selection of snacks to students at Senior High School 16 Makassar before and after nutrition education through the booklet media. The population of this research is the students of class X and XI Senior High School 16 Makassar, with a total sample of 59 students. The sample was conducted using stratified random sampling. The results showed that there are change choice healthy snack (p=0,011) and sweet snack (p=0,046) before and after the intervention. There are also changes in the number of healthy snacks consumption (p=0,02) and sweet snack (p=0,041). The conclusion from this study that there is change choice snack before and after nutrition education through the booklet media at Senior High School 16 Makassar.