bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics
Authors: Rogozina N. V. , Vasil’ev V. V. , Bezverhaja N. S. , Ivanova R. A. , Ushakova G. M. , Romanova E. S. 
Published: July 2022

Objective: to analyze clinical manifestations, diagnostic and therapeutic approaches to management of pregnant women with cytomegalovirus infection for optimization of clinical and laboratory diagnostics and reduction of risks of congenital cytomegalovirus infection in the postnatal period.Materials and methods: in the article describe results a retrospective study the pregnancy course of 92 women who had 94 children with a confirmed congenital manifest form of cytomegalovirus infection. The inclusion criteria in main group were women aged 18-40 years and presence the results of examination for TORCH-syndrome in the first trimester of pregnancy, negative results for HIV. Markers of cytomegalovirus infection were determined by PCR (blood, vaginal secretions) and serologically (IgM, IgG to CMV-infection).Findings: the study showed that acute cytomegalovirus infection was documented during pregnancy in 18.4% of cases, and recrudescence of CMV-infection only in 33.6% of cases. Acute cytomegalovirus infection was asymptomatic in 35.3% of patients, the rest had nonspecific symptoms in the form of fatigue and headache, cholestasis was registered in 35.2% of cases, whereas with recrudescence of cytomegalovirus infection, catarrhal symptoms in the form of rhinitis and pharyngitis prevailed 42,8% cases, p<0,05. 15 people received therapy during pregnancy: 2 of them – antiviral (valgancyclovir), 11 – immunocorrective (interferon2alfa) and 2 – pathogenetic therapy (blood transfusion to the fetus for anemia). Based on the literature data and obtained by analyzing management tactics of the observed pregnant women, an algorithm for the management of pregnant women with cytomegalovirus infection was created.Conclusion: the study made it possible to substantiate algorithm of diagnosis and tactics management of cytomegalovirus infection in immunocompetent pregnant women and gave recommendations for obstetricians and gynecologists about alertness regarding cytomegalovirus infection.
Remnant Cholesterol and Its Visit-to-visit Variability Predict Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus: Findings from the ACCORD Cohort
Authors: Fu Liyao , Tai Shi , Sun Jiaxing , Zhang Ningjie , Zhou Ying , Xing Zhenhua , Wang Yongjun , Zhou Shenghua 
Published: July 2022

<p> </p>
<p><em><strong>Objective:</strong></em> Remnant cholesterol (remnant-C) predicts atherosclerotic cardiovascular disease, regardless of LDL cholesterol (LDL-C) levels. This study assessed the associations between remnant-C and cardiovascular outcomes in type 2 diabetes mellitus. </p>
<p><em><strong>Research design and methods:</strong></em> This post-hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial used patient (type 2 diabetes >3 months) remnant-C and major adverse cardiovascular event (MACE) data from the study database. The associations between remnant-C and MACEs were evaluated using Cox proportional hazards regression analyses. We examined the relative MACE risk in remnant-C versus LDL-C discordant/concordant groups using clinically relevant LDL-C targets by discordance analyses<em>.</em></p>
<p><em><strong>Results:</strong></em> The baseline analysis included 10,196 participants, with further visit-to-visit variability analysis including 9650 participants. During follow-up (median, 8.8 years), 1815 (17.8%) patients developed MACEs. After adjusting for traditional cardiovascular risk factors, each 1-SD increase in remnant-C was associated with a 7% higher MACE risk (HR=1.07, 95% CI: 1.02-1.12; P=0.004). In the fully adjusted model, the visit-to-visit remnant-C variability calculated using logSD (HR=1.41, 95% CI: 1.18-1.69, P<0.001) and logARV (HR=1.45, 95% CI: 1.22-1.73, P<0.001) was associated with MACEs. Residual lipid risk (remnant-C ³31 mg/dL) recognized individuals at a higher MACE risk, regardless of LDL-C concentrations. Within each LDL-C subgroup (>100 or ≤100 mg/dL), high baseline remnant-C was associated with a higher MACE risk (HR=1.37, 95% CI: 1.09-1.73; P=0.007; HR=1.22, 95% CI: 1.04-1.41; P=0.015, respectively).</p>
<p><em><strong>Conclusions:</strong></em> Remnant-C levels were associated with MACEs in type 2 diabetic patients independent of LDL-C, and visit-to-visit remnant-C variability helped identify those with higher cardiovascular risk.</p>
Nivel de innovación del talento humano en pymes apoyadas en el SENA CGA
Authors: Arévalo Hernández Franklin Giovanni 
Published: July 2022

La innovación y la participación activa del talento humano en las pymes es base fundamental para que las organizaciones potencialicen la productividad y permitan el desempeño de cada integrante de la misma. La estructura de esta investigación trabajó bajo dos metodologías; las cuales fueron bibliográfica y la investigación IAP (Investigación de Acción Participativa). El proyecto se enfoco en identificar la capacidad innovadora del talento humano de pymes apoyadas desde las estrategias de formación del SENA CGA, realizando un desarrollo conceptual, sobre el nivel de innovación de pymes en Colombia y la capacidad innovadora de su talento humano, estos conceptos se utilizaron como apoyo para el desarrollo del proyecto basado en los temas expuestos anteriormente, luego de esto se aplico un diagnóstico a dichas organizaciones, para analizar sus puntos de vista y el manejo en cuanto a la innovación, la información recabada permitio establecer que se promueven pocas estrategias empresariales y la baja participación que tiene el talento humano, en este sentido existe la necesidad de diseñar e implementar estrategias y herramientas para potencializar la participación activa de sus colaboradores con relación a este tema.
Los retos del derecho en las sociedades abiertas e híbridas: el derecho en medio de la dinámica de la identidad y de las diferencias
Authors: Agudelo Ramírez Martín 
Published: July 2022

"¿Qué es el hombre, si el principal bien y el interés de su vida consistieran tan sólo en dormir y comer? Una bestia, nada más. Seguramente. Aquel que nos ha creado como una inteligencia tan vasta que abarca lo pasado y el porvenir no nos dio tal facultad y la divina razón para que se enmoheciera en nosotros por falta de uso".
Racionalización formal del derecho moderno y justicia sustantiva.
Authors: Munné Guillermo J. 
Published: July 2022

Entre los diversos aportes teóricos que hicieron de Max Weber una de las figuras principales del pensamiento social del siglo XX, encontramos su sociología del derecho que tiene como tema el proceso de racionalización del derecho occidental. Max Weber estudió ese proceso como una racionalización de tipo formal que es acompañada, aún en su última etapa moderna, de tendencias contrarias que se dirigen hacia la materialización del derecho. A partir de estos trabajos de Weber se ha construido una crítica del Estado social y una oposición a tomar los derechos sociales como derechos fundamentales, consistentes en afirmar que tal proyecto político conspira contra las notas de racionalidad del Estado de derecho por implicar la introducción de exigencias materiales de justicia que degradan la norma superior del ordenamiento jurídico, es decir, la Constitución.
El impacto institucional de la reelección
Authors: Estrada Villa José Armando 
Published: July 2022

La reelección presidencial puede analizarse desde una doble perspectiva: la perspectiva personal o la institucional. Mirarla desde el ángulo del enfoque personal, le resta posibilidad al debate, por cuanto no puede desconocerse que el presidente Álvaro Uribe genera comportamientos pasionales entre seguidores y contradictores. U nos lo defienden con ardentía por sus logros en seguridad, y otros lo atacan con pasión por el escaso avance en las políticas de empleo y lucha contra la pobreza. Lo cierto es que por este camino, al final los argumentos se reducirían al amor o desamor que sienten los colombianos frente al primer mandatario.
Heidegger y su concepto de mundo
Authors: Estrada Villa Armando 
Published: July 2022

Este artículo tiene el propósito de reflexionar sobre los conceptos de Dasein, tiempo y mundo en la construcción filosófica de Martín Heidegger. Para ello, el autor propone considerar que Dasein es el mismo ser humano que pregunta y responde por el ser, que puede transformarse y desplegar todas sus posibilidades y que debe estar abierto a sí mismo, al mundo y a los demás. Al tiempo lo mira como un elemento integrante de la existencia humana, en el que se producen los acontecimientos y constituye horizonte para toda la comprensión del ser, y que puede estudiarse como tiempo de la vida cotidiana, de la naturaleza y del mundo. En tanto que al mundo lo entiende como aquello que preexiste al ser, de lo que somos inseparables y que de alguna manera determina nuestra existencia porque estamos inmersos en su dinámica y en sus problemas. Este escrito concluye que el enfoque de Heidegger es sobre la existencia humana y que con base en estos conceptos ofrece una mirada práctica que lleva al hombre a la autorreflexión, a la autocomprensión, lo que le permite construir su proyecto de vida y alcanzar la autenticidad.
In Silico Study of Thioguanine Derivatives as Hemopexin Matrix Metalloproteinase9 (PEX-9) Inhibitors
Authors: Putra Kevin Cahaya , Nugroho Ervan Setyo , Wisnumurti Yohanes Krisna , Dewa Sangga Putra , Putra Jati Benedictus Wisnu , Tiara Reynaldo , Setyaningsih Dewi , Hariono Maywan 
Published: July 2022

Matrix Metalloproteinase (MMP) was broadly studied as one of the protein targets in stopping angiogenesis. The most common target in MMP, i.e., the catalytic site, is reported as being the non-selective target for inhibition amongst all MMPs, but its inhibition is associated with adverse side effects. Hemopexin in MMP9 (PEX9) was found to be different to the other domains in the MMP family, which could be the next target for anticancer due to the availability of its crystal structure in the protein data bank (pdb). In this study, we design the analogues of a compound from the ZINC database bearing a pyrimidinone scaffold which previously showed activity as a PEX9 inhibitor using molecular docking. The docking is carried out using Autodock 4.0 with parameters such as 250 run and lammarckian genetic algorithm. The result shows that six designed compounds have a free energy of binding from -7.0 to -11.0 kcal/mol. The important amino acid residues which are involved in the hydrogen bond interaction are ARG106, GLU60, GLU14, and GLN154. In conclusion, the six design compounds could give an insight mechanism to inhibit the PEX-9 activity in silico.Keywords: Docking, Hemopexin, MMP9, PEX9, Thioguanine
Case report: early class III correction using titanium dental implants and facemask therapy: a 24-year follow-up
Authors: Khan Nida , Stamatis John , Bower Robert , Henry Patrick J. , Goonewardene Mithran 
Published: July 2022

Abstract
The management of a Class III malocclusion in the mixed dentition presents with many challenges, in particular, the post-treatment growth-related changes which can continue into adulthood. This case report describes the multidisciplinary management of a 9-year-old female using titanium dental implants, rapid maxillary expansion and a Delaire facemask. Pre-treatment, post-treatment and long-term follow-up records of the patient are presented.
Molar uprighting using a newly designed segmental wire: a case report
Authors: Bae Seong-Min , Kim Ho-Jin 
Published: July 2022

Abstract
The ectopic eruption path of a permanent molar can cause incomplete emergence through interference by an adjacent tooth, early loss of a primary molar, or an arch length discrepancy. It is clinically important to determine the appropriate appliance that may easily be placed for the considered application of a molar corrective force. A newly designed appliance is introduced for the distal uprighting of an ectopically erupting molar and supported by two case presentations. The current technique of using a segmental wire incorporating double-sided hooks may easily and effectively resolve this problem.
Razones para promover la motivación en la Educación Superior
Authors: Ruiz Jose , García Muñoz Luis Héctor , Flores Barajas Silvana , De Santiago Barragán Antonio 
Published: July 2022

En la actualidad se tienen programas especiales, desde niveles básicos hasta la educación superior, para desarrollar la creatividad en superdotados, en EEUU, UK y otros países. Sin embargo, de acuerdo a los expertos, todos somos creativos, pero debemos ser formados (o entrenados). Además, se sabe de la independencia de la creatividad con coeficientes intelectuales mayores a 120.
En un recorrido por las opiniones y teorías de creatividad de los especialistas en el tema, se sustenta lo arriba mencionado, para luego revisar las características que inciden en la creatividad. Se destaca la motivación, porque de manera natural ya se incluye (o se debe incluir) en la educación tradicional al menos en la educación superior.
A manera de verificación, se llevó a cabo un ejercicio para motivar a una muestra de conveniencia, valorando sus capacidades creativas antes y después, con el instrumento de valoración Torrance Tests of Creativity Thinking (TTCT) en su versión figurativa A (pre-test) y B (post-test).
Los resultados fueron muy concluyentes, confirmando lo expresado por los expertos, abriendo la posibilidad para todo estudiante promedio, de ser motivado para la creatividad en general, no para inventar o diseñar un producto patentable solamente, sino para ser creativo en cada tarea profesional que desarrolle, y que lo lleve a ser un gran emprendedor.
Además de las estrategias propuestas por algunos autores, está el ejercicio que se realizó, que comprende 15 horas presenciales y otras tantas por parte de los involucrados. Se añade también un esquema de motivación, muy utilizado por universidades privadas, y que no hay limitante que impida incorporarlo en la educación pública.
Satisfacción con la vida en universitarios del sur de México
Authors: Ocaña Zúñiga Jesús , García Lara Germán Alejandro , Cruz Pérez Oscar , Pérez Jiménez Carlos Eduardo 
Published: July 2022

La satisfacción con la vida se puede definir como juicio cognitivo que las personas hacen de su vida con perspectiva espacio-temporal. Medir la satisfacción con la vida puede ser particularmente útil para evaluar el desarrollo social, identificar condiciones necesarias para el bienestar e incluso para orientar el diseño de estrategias preventivas de la salud mental o problemáticas psicosociales. Por ello, es pertinente su estudio con universitarios, debido a que en esta etapa los jóvenes son vulnerables pues se encuentran en el transitando de la adolescencia hacia la adultez, lo que implica una nueva carga de responsabilidades consigo mismo y con su proyecto de vida. En este contexto este trabajo tiene por objetivo medir la satisfacción con la vida de estudiantes universitarios del sur de México y los posibles efectos que las variables Sexo, Lengua originaria y Carrera puedan tener sobre ella. Para ello se recuperó una muestra de 1,278 participantes, a quienes se les aplicó la escala de satisfacción con la vida de Diener (1985), en su versión traducida al castellano de 5 ítems. Los resultados apuntan a que los participantes tienen una alta satisfacción con la vida, con diferencias significativas por Lengua Originaria y Carrera, no así para Sexo. Estos resultados cobran notoriedad en el contexto pues Chiapas, demarcación del sur de México, es una entidad culturalmente diversa con altos índices de rezago social y bajos indicadores de desarrollo humano.
ПРОДУКТИВНІ ЯКОСТІ ГІБРИДІВ РІПАКУ ОЗИМОГО (BRASSICA NAPUS L.)
Authors: Humeniuk H. B. , Khomenchuk V. O. , Matsiuk O. B. , Yavorivskyi R. L. , Sodomora M. M. , Drobyk N. M. 
Published: July 2022

The content of monosaccharides in flower nectar, nectar productivity, as well as the viability of pollen of hybrids Brassica napus L. Kuga, Dk Expression, Emerald (Smaragd) and Abacus were studied.
It was found that during the first and second pollen crops the most intensive germination of pollen grains occurred in Emerald (Smarahd) (75 % and 87 %, respectively), and Kuha (80 % and 90 %, respectively) hybrids. In crops of other studied hybrids - Dekalb Expression, Abacus, PT 264 - inhomogeneous pollen grains of different sizes were observed, the percentage of pollen germination was lower. It was found that the average number of monosaccharides is much higher in hybrids Abacus and Kuha (27.5 and 36 mg / 30 flowers, respectively). Kuha (156.8 kg) and Emerald (Smaragd) (81.4 kg) hybrids have the highest nectar fertility. Analysis of monosaccharides content in flower nectar, nectar fertility and pollen viability, as well as the correlation of these indicators allows to predict in the future among the studied hybrids higher productivity of hybrids Kuha and Emerald (Smaragd).
TECHNOLOGIES OF TEACHING TO IDENTIFY FAKES IN THE “INFOMEDIA LITERACY” COURSE
Authors: KUSHNIR OKSANA , RESHETUKHA TETIANA 
Published: July 2022

Today, in the conditions of increased information pressure, the need for critical perception of media messages has become acute. Media literacy skills should become the basic competencies of every person. In this context, the significance of the course “Information Media Literacy” is growing as its aim is to develop in students ability to thoughtfully perceive media materials and critically interpret them, including identification of fakes and manipulations. The Russian-Ukrainian war provoked a quantitative increase in the deliberate spread of misinformation, which includes fakes. Their spread is extremely dangerous. False messages can be used to manipulate peopleʼs minds and cause interpersonal and global conflicts. The purpose of the publication is to substantiate the need and provide technologies for the development of skills to identify fake messages while studying the course “Information Media Literacy”. To achieve this goal, the following methods have been used: descriptive (classification, document analysis), media linguistic (rhetorical, cognitive, discursive analysis of media texts), content monitoring, content analysis.
The research findings revealed that awareness of the need to include media literacy in the educational process dates back to the 60s of the twentieth century, and its main objectives were formulated by UNESCO in 2007. In 2010, the Concept of Implementing Media Education in the educational process was adopted in Ukraine. The discipline “Information Media Literacy” became the basis for its implementation in TNPU, which involves the development of studentsʼ relevant media and cultural competencies. The formation of critical immunity of the media audience is based on the algorithm of identification of fake information. The study of fake markers was the subject of practical educational technologies tested in the educational process of TNPU. The proposed tasks are designed to develop skills for recognizing signs of fakeness in the information space. Each task provides methodical tools: the purpose, program competencies and learning outcomes, the order of performing and options for justification of answers. In particular, the tasks involved developing skills to work with sources of information; ask questions, justify oneʼs own point of view; evaluate and interpret events; identify fakes, propaganda and manipulation tools in texts and headlines. Tasks are aimed at achieving the following learning outcomes by students: the ability to demonstrate the appropriate level of critical thinking and understanding of the level of information impact on the individual; ability to interpret current phenomena (fake news, information attacks, manipulation, etc.) of the information space for a wide audience, to increase the level of its media literacy.
CONTENT-LANGUAGE INTEGRATED LEARNING IN THE CONTEXT OF EUROPEAN INTEGRATION
Authors: LEVCHYK IRYNA 
Published: July 2022

The conditions of formation of content-language integrated learning (CLIL) have been characterized with a number of theoretical and methodological factors, that have influenced the process of development from different perspectives. The origin of CLIL is connected with the prior methodological approach to second language acquisition – content based language instruction. It has been established with aim to reduce the gap in knowledge of English learners between spoken everyday English and Academic language. The reflection of the psycholinguistic views in CBI led to adoption of concepts of comprehensive output, input hypothesis and proximal zone of development in its subsidiary method (CLIL). Besides this, another methodology affecting formation of content-language integrated learning, known as “English for special purposes”, is also contextualized by specialty content, and they share common goals of learning. However, ESP keeps its focus on language, not content. The comparative analysis of CBI and ESP key features reveals the theoretical and methodological conditions of CLIL formation.
The modified variations of CLIL approach, applied all over Europe like Bilingual Content Teaching, Bilingual Subject Teaching or Content-Based Language Teaching, relied on a common concept of learning a foreign language with a shift of focus from the language itself to the content expressed in this language. The bilingual model of education in European countries adopted the provisions of content-language integrated learning methods at the mainstream level in school education in France, Ireland, Finland, Estonia, Latvia, Poland, the Czech Republic, and it has been partially implemented within pilot projects in the UK, Spain, Germany, Italy and Sweden. The method was strongly supported by policy of the European Union and European Commission with an aim of promotion of language learning and linguistic diversity. The support of the European language policy and ideology was reflected in a number of projects launched in order to promote methods based on international cooperation, such as “Content and Language Integrated Learning in Germany” (CLILiG), as well as with the support of the Council of Europe “CLIL Quality Matrix” (2004) and the European Regional Action Scheme for the Mobility of University Students (ERASMUS).