bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pemberian Capriglandin dan Lutalyse Terhadap Service Perconception, Conception Rate dan Ovarium pada Sapi Simmental
Authors: Bahagia Sari , Hendri Hendri , Udin Zaituni 
Published: August 2022

Penelitian ini bertujuan mengetahui pengaruh pemberian PGF2? (Capriglandin dan Lutalyse) terhadap service perconception, conception rate dan ovarium, folikel, dan corpus luteum pada induk sapi simmental. Penelitian menggunakan 24 ekor induk sapi Simmental yang tidak bunting di BPTUHPT Padang Mengatas, Sumatera Barat dengan kriteria tidak estrus, siklus estrus normal dan tidak mengalami gangguan reproduksi. Metode eksperimen dengan Rancangan Acak Lengkap Pola Faktorial 2 x 2 x 6 bila terdapat hasil berbeda nyata maka dilanjutkan uji lanjutan DMRT. Faktor A adalah preparat hormon prostaglandin (Capriglandin dan Lutalyse). Faktor B adalah dosis (3 ml dan 5 ml). Perlakuan A1B1 = Capriglandin 3 ml; A1B2 = Capriglandin 5 ml; A2B1 = Lutalyse 3 ml; dan A2B2 = Lutalyse 5 ml yang masing-masing terdapat enam ulangan. Baik Capriglandin dan Lutalyse diberikan secara single dosis intra muskuler. Parameter yang diukur service perconception, conception rate dan ukuran diameter panjang ovarium. Hasil analisis antara preparat hormon Capriglandin dan lutalyse terhadap jumlah dosis 3 ml dan 5 ml menunjukan hasil berbeda nyata (P<0.05) terhadap conception rate dan ovarium. Hasil analisis tidak berbeda nyata (P>0,05) terhadap service perconception. Prostaglandin dengan zat aktif dinoprost tromethamine hanya efektif bila ada CL fungsional, yaitu antara hari ke-7 sampai hari ke-18 siklus estrus. Penggunaan terbaik pada pemberian Capriglandin dengan dosis 5 ml.
THE CHALLENGES OF LEARNING ENGLISH AS A FOREIGN LANGUAGE IN COMMUNICATIVE APPROACHES IN HIGHER EDUCATION
Authors: ISMETI Enes 
Published: August 2022

The purpose of this study was to look at the difficulties students have when learning English as a foreign language in higher education. This paper reports on the results of an interview of 30 randomly selected students and four professors of the Faculty of Philology and English language department, respectively, at the University “Ukshin Hoti” Prizren.
It is critical to provide learners with the best possible support in terms of a helpful learning environment and adequate and meaningful language experience when learning a second language.
Furthermore, students of English language can work to enhance their English skills, making language teaching and learning more effective and relevant for both lecturers and students.
After identifying some of the challenges in English language learning and use in higher education in the Kosovar context, this study will attempt to address some of the critical issues identified and suggest some measures to deal with them more efficiently than what is currently being done. One of the first principles to consider when planning and designing English language programs is the need to identify the goals of teaching English in the sociocultural context in which the learning is taking place in no uncertain terms. Finally, this research has recommended overcoming these challenges and future research.
Військова стоматологія на теренах України: історична ретроспектива та сучасність
Authors: Сегеда С. П. , Грицюк В. М. 
Published: August 2022

У статті здійснено ретроспективний аналіз розвитку військової стоматології на українських теренах від найдавніших часів до сьогодення. Основну увагу приділено питанням становлення й розвитку стоматологічного забезпечення у Збройних Силах України зі здобуттям нашою державою незалежності, здійснено історичну періодизацію цих процесів, розкрито причини втрати спроможності надання сучасної стоматологічної допомоги в польових умовах.
З початком антитерористичної операції на Сході України було відновлено роботу штатних пересувних стоматологічних кабінетів, які сьогодні надають медичну допомогу військовослужбовцям, залученим до заходів з відсічі широкомасштабній збройній агресії Російської Федерації проти України. Центральна стоматологічна поліклініка стала науково-методичним та практичним центром вітчизняної військової стоматології та водночас навчальною базою підготовки майбутніх військових стоматологів. На основі дослідженого досвіду організації та здійснення стоматологічної допомоги опрацьовано модель надання стоматологічної допомоги військовослужбовцям в зоні операції Об’єднаних сил.
Tiempos de recuperación con tres planes de inducción anestésica en hembras caninas sometidas a ovariohisterectomía
Authors: Espinoza Japón Félix , Rubio Arias Pablo 
Published: August 2022

Introducción. En todo acto quirúrgico, proporcionar un correcto plan anestésico, resulta crucial puesto que se debe mantener una analgesia, preanestesia, inducción, y mantenimiento anestésico adecuado, en base a los requerimientos de cada paciente a intervenir, tomando en cuenta que el plan anestésico es la parte primordial en las cirugías. Objetivo Comparar los tiempos de recuperación en tres planes de inducción anestésica en hembras caninas sometidas a ovariohisterectomía, es relevante su importancia, el establecer un plan anestésico adecuado, nos brinda mayor seguridad y eficacia en pacientes intervenidos quirúrgicamente, Metodología. Se utilizó un análisis positivista cuantitativo experimental, también se realizó una estadística descriptiva, usando tablas y figuras para comparar los planos anestésicos, además de usar el modelo ANOVA, una prueba de Tukey al 95% para realizar comparaciones dos a dos y ver cuál es el mejor plan anestésico en cuanto al tiempo de recuperación de inducción anestésica. Resultados. Se tomaron los datos de 30 caninas hembras jóvenes, del Consultorio Veterinario Espinoza-Vet las mismas que fueron sometidas a cirugía (OVH) para la evaluación de los planos anestésicos. Se aplicó un plan anestésico a cada grupo experimental (10 caninos cada grupo). Los grupos de trabajo (unidades experimentales) fueron establecidos de una manera completamente ramdomizada. Conclusión. Se concluyó que todos los fármacos utilizados, fueron administrados por vía IV, de manera individual cada fármaco y de forma consecutiva; Se encontró que el tiempo de recuperación al realizar la comparación entre grupos, es estadísticamente significativo (p<0.05). De este modo, existe un efecto del plano anestésico sobre el tiempo de recuperación pos-quirúrgica, es decir, los valores del tiempo de recuperación son distintos entre los planes, por consiguiente, el tiempo de recuperación es diferente en todos los grupos.
Management of Fractured Endodontically Treated Tooth by Fibre Optic Composite Post-Core-Crown: A Case Report
Authors: Hoque Mahrufa , Ahmed Mohammed Ashraf , Helal Md Syeed Al 
Published: August 2022

The restoration of endodontically treated tooth is a subject that has been evaluated and discussed widely in the dental literature. The goal of dental treatment is to provide optimal oral health, aesthetics and functions. The successful treatment of a badly broken endodontically treated tooth depends not only on the success of the endodontic treatment but also on good prosthetic reconstruction. The prosthetic treatment on a seriously damaged, endodontically treated tooth often requires an endodontic post as an additional retention element for core build up prior to crown restoration. This case report presents a male patient of 22 years of age with prosthetic crown fracture of endodontically treated maxillary left central incisor tooth. The following clinical case represents the clinical steps involved in the utilization of a fibre-reinforced composite post-core in a maxillary left central incisor and the subsequent treatment with a full veneer crown.
Central Medical College Journal Vol 5 No 2 Jul 2021 PP 126-130
Studi Kasus SDGs 4.4.1: Kemampuan ICT Mahasiswa Pendidikan Matematika dalam Mendesain Perangkat Pembelajaran 21st CLD
Authors: Manurung Felisia Oktovia , Pujiastuti Heni 
Published: August 2022

In this era of digital revolution, education is slowly being sought to use technology in its implementation. Besides the many products that are created to support the learning process, this of course needs to be in line with the capabilities of its users, namely students, educators and prospective educators. The ability to operate technology is needed so that educational technology products that are created are effective, especially to meet the learning needs of the 21st century. Therefore, the researcher intends to research with the aim of analyzing the ICT ability of Mathematics Education students at Sultan Ageng Tirtayasa University in designing learning devices that involve technology as one of the dimensions of 21st Century Learning Design (CLD). This study uses a qualitative descriptive method by distributing a test instrument about ICT knowledge and rating scale questionnaires. This study collects information from result of test insrument, questionnaires and various supporting literature that can be used as a basis for research. Based on this, it was found that the students' ICT abilities were on a good scale on average overall but there were still skills that didn’t reach the indicators.
El kavrama kuvveti ile periferik kas kuvveti arasındaki ilişki; Kesitsel çalışma
Authors: EVYAPAN Seda , KARAHAN Ali Yavuz 
Published: August 2022

AMAÇ; Bu çalışmanın amacı genç erişkin yaş grubunda el kavrama kuvveti (EKK) ile omuz (deltoid), sırt (trapez), kalça ekstansör (gluteus maksimus) ve fleksör (psoas majör) kasları ve diz ekstansör (kuadriseps) kas kuvvetleri arasındaki ilişkiyi ortaya koymaktır.
GEREÇ VE YÖNTEM; Kesitsel araştırma niteliğinde yapılan ve 18-25 yaş aralığında 50 katılımcı ile tamamlanan bu çalışmada, el kavrama, pinch, omuz, sırt, kalça ve diz kas kuvveti ölçümleri dinamometre ile yapılmıştır. Her kas grubu için ölçüm 10 saniye arayla 3 kez uygulanmış ve ortalama değer “kg” birimi ile çalışmada kullanılmıştır.
BULGULAR; Erkek katılımcıların kas kuvveti ölçümleri, kadın katılımcılara göre istatistiksel olarak daha fazlaydı (p
Dielectric dispersion characteristics of the phospholipid bilayer with subnanometer resolution from terahertz to mid-infrared
Authors: Zhang Ziyi , Li Yangmei , Xiang Zuoxian , Huang Yindong , Wang Ruixing , Chang Chao 
Published: August 2022

There is growing interest in whether the myelinated nerve fiber acts as a dielectric waveguide to propagate terahertz to mid-infrared electromagnetic waves, which are presumed stable signal carrier for neurotransmission. The myelin sheath is formed as a multilamellar biomembrane structure, hence insights into the dielectric properties of the phospholipid bilayer is essential for a complete understanding of the myelinated fiber functioning. In this work, by means of atomistic molecular dynamics simulations of the dimyristoylphosphatidylcholine (DMPC) bilayer in water and numerical calculations of carefully layered molecules along with calibration of optical dielectric constants, we for the first time demonstrate the spatially resolved (in sub-nm) dielectric spectrum of the phospholipid bilayer in a remarkably wide range from terahertz to mid-infrared. More specifically, the membrane head regions exhibit both larger real and imaginary permittivities than that of the tail counterparts in the majority of the 1–100 THz band. In addition, the spatial variation of dielectric properties suggests advantageous propagation characteristics of the phospholipid bilayer in a relatively wide band of 55–85 THz, where the electromagnetic waves are well confined within the head regions.
Transformed extracellular vesicles with high angiogenic ability as therapeutics of distal ischemic tissues
Authors: Ngo Nhat-Hoang , Chang Yun-Hsuan , Vuong Cat-Khanh , Yamashita Toshiharu , Obata-Yasuoka Mana , Hamada Hiromi , Osaka Motoo , Hiramatsu Yuji , Ohneda Osamu 
Published: August 2022

Introduction: The therapeutic effects of endothelial progenitor cells (EPC) in neovascularization have been suggested; however, to date, few studies have been conducted on the ability of EPC-derived extracellular vesicles (EV) to rescue the ischemic tissues. In order to examine the functional sources of EV for cell-free therapy of ischemic diseases, we compared the functions of EPC-EV and those of Wharton’s Jelly-derived mesenchymal stem cell (WJ-EV) in the flap mouse model.Results and conclusion: Our results demonstrated that in the intravenous injection, EPC-EV, but not WJ-EV, were uptaken by the ischemic tissues. However, EPC-EV showed poor abilities to induce neovascularization and the recovery of ischemic tissues. In addition, compared to EPC-EV, WJ-EV showed a higher ability to rescue the ischemic injury when being locally injected into the mice. In order to induce the secretion of high-functional EPC-EV, EPC were internalized with hypoxic pre-treated WJ-EV, which resulted in a transformed hwEPC. In comparison to EPC, hwEPC showed induced proliferation and upregulation of angiogenic genes and miRNAs and promoted angiogenic ability. Interestingly, hwEPC produced a modified EV (hwEPC-EV) that highly expressed miRNAs related to angiogenesis, such as miR-155, miR-183, and miR-296. Moreover, hwEPC-EV significantly induced the neovascularization of the ischemic tissues which were involved in promoting the proliferation, the expression of VEGF and miR-183, and the angiogenic functions of endothelial cells. Of note, hwEPC-EV were highly uptaken by the ischemic tissues and showed a greater effect with regard to inducing recovery from ischemic injury in the intravenous administration, compared to EPC-EV. Therefore, hwEPC-EV can be considered a functional candidate for cell-free therapy to treat the distal ischemic tissues.
Pan-cancer analysis identifies YTHDF2 as an immunotherapeutic and prognostic biomarker
Authors: Liu Weiwei , Liu Chaoqun , You Jia , Chen Zilin , Qian Cheng , Lin Wandie , Yu Lina , Ye Lele , Zhao Liang , Zhou Rui 
Published: August 2022

Background: N6-methyladenosine (m6A) modification is a dynamic and reversible post-transcriptional RNA modification prevalent in eukaryotic cells. YT521-B homology domain family 2 (YTHDF2) has been identified as a member of m6A reader protein involving in many vital biological processes, whereas its role and functional mechanisms in cancers remain unclear.Methods: Bioinformatics analyses were performed on multiple databases including GTEx, TCGA, GEO and Cbioportal to explore the connection between YTHDF2 expression and its genomic changes including tumor mutation burden, microsatellite instability and mismatch repair in 33 different cancer types. We also investigated the association of YTHDF2 expression with prognosis, immune infiltration, tumor microenvironment, immune checkpoints and chemokines. Besides, the correlation of YTHDF2 expression with copy number variation and promoter methylation was also studied in tumors compared with normal tissues. At last, we analyzed the protein-protein interacting network and related genes of YTHDF2 to enrich its potential functional mechanism in tumor development and progression. Real-time qPCR was used to verify the expression of YTHDF2-related genes in colorectal cancer cells, and immunohistochemical staining was adopted to verify immune infiltration in tissue sections from 51 hepatocellular carcinoma patients.Results: YTHDF2 was overexpressed in a majority of tumor types and associated with their poor overall survival, progression-free interval, and disease-specific survival. The correlation of YTHDF2 expression with tumor mutation burden, microsatellite instability and mismatch repair was also detected in most of the tumor types. Moreover, YTHDF2 might participate in the immune regulation through influencing the expression of immune checkpoint genes and the infiltration of immunocytes in tumor microenvironment. Notably, we demonstrated a positive correlation between YTHDF2 expression and the infiltration of CD8+ T cells and macrophages in many tumors, and it was verified in 51 clinic hepatocellular carcinoma tissues. In addition, the involvement of YTHDF2 in “Spliceosome” and “RNA degradation” were two potential functional mechanisms underlying its influence on tumor progression. The regulation of YTHDF2 on predicted genes has been verified in CRC cells.Conclusion: YTHDF2 might be a new therapeutic target and a potential biomarker of cancer immune evasion and poor prognosis.
Searching guidelines for scalable and controllable design of multifunctional materials and hybrid interfaces: Status and perspective
Authors: Echeverrigaray Fernando G. , Alvarez Fernando 
Published: August 2022

The urgent need to address the global sustainability issues that modern society is currently facing requires the development of micro and nanotechnologies, which rely largely on functional materials. Beyond studies focused solely on low-dimensional materials, broader research related to multifunctionality has shown that the major efforts to meet these criteria for new electronic, photonic, and optoelectronic concepts, particularly to achieve high-performance devices, are still challenging. By exploiting their unique properties, a comprehensive understanding of the implications of research for the synthesis and discovery of novel materials is obtained. The present article encompasses innovation research as an alternative optimization and design for sustainable energy development, bridging the scaling gap in atomically controlled growth in terms of surface heterogeneity and interfacial engineering. In addition, the corresponding research topics are widely regarded as a scientometric analysis and visualization for the evaluation of scientific contributions into the early 20 years of the 21st century. In this perspective, a brief overview of the global trends and current challenges toward high-throughput fabrication followed by a scenario-based future for hybrid integration and emerging structural standards of scalable control design and growth profiles are emphasized. Finally, these opportunities are unprecedented to overcome current limitations, creating numerous combinations and triggering new functionalities and unparalleled properties for disruptive innovations of Frontier technologies.
Metagenomic next-generation sequencing for identifying pathogens in patients with rheumatic diseases and diffuse pulmonary lesions: A retrospective diagnostic study
Authors: Jiang Juan , Yang Wei , Wu Yanhao , Peng Wenzhong , Zhang Wenjuan , Pan Pinhua , Hu Chengping , Li Yisha , Li Yuanyuan 
Published: August 2022

ObjectiveLung involvement is a major cause of morbidity and mortality in patients with rheumatic diseases. This study aimed to assess the application value of metagenomic next-generation sequencing (mNGS) for identifying pathogens in patients with rheumatic diseases and diffuse pulmonary lesions.MethodsThis retrospective study included patients who were diagnosed with rheumatic diseases and presenting diffuse pulmonary lesions on chest radiography in Xiangya Hospital from July 2018 to May 2022. Clinical characteristics were summarized, including demographics, symptoms, comorbidities, radiological and laboratory findings, and clinical outcomes. Pulmonary infection features of these patients were analyzed. Furthermore, diagnostic performance of mNGS and conventional methods (including smear microscopy, culture, polymerase chain reaction assay, and serum immunological test) in identifying pulmonary infections and causative pathogens were compared.ResultsA total of 98 patients were included, with a median age of 58.0 years old and a female proportion of 59.2%. Of these patients, 71.4% showed the evidence of pulmonary infections. Combining the results of mNGS and conventional methods, 129 infection events were detected, including 45 bacterial, 40 fungal and 44 viral infection events. Pulmonary mixed infections were observed in 38.8% of patients. The detection rates of mNGS for any pathogen (71.4% vs 40.8%, P &lt; 0.001) and mixed pathogens (40.8% vs 12.2%, P &lt; 0.001) were higher than that of conventional methods. Moreover, mNGS had a significantly higher sensitivity (97.1% vs. 57.1%, P &lt; 0.001) than conventional methods in identifying pulmonary infections, while its specificity (92.9% vs. 96.4%, P = 0.553) were comparable to conventional methods. Antimicrobial and antirheumatic treatments were markedly modified based on mNGS results in patients with rheumatic diseases and diffuse pulmonary lesions.ConclusionsFor patients diagnosed with rheumatic diseases and presenting diffuse pulmonary lesions, mNGS is a powerful complement to conventional methods in pathogen identification due to its high efficiency and broad spectrum. Early application of mNGS can provide guidance for precision treatment, and may reduce mortality and avoid antibiotic abuse.
Real-world experience with the cusp-overlap deployment technique in transcatheter aortic valve replacement: A propensity-matched analysis
Authors: Maier Oliver , Piayda Kerstin , Binnebößel Stephan , Berisha Nora , Afzal Shazia , Polzin Amin , Klein Kathrin , Westenfeld Ralf , Horn Patrick , Jung Christian , Kelm Malte , Veulemans Verena , Zeus Tobias 
Published: August 2022

BackgroundThe implantation depth (ID) is a critical condition for optimal hemodynamic and clinical outcomes in transcatheter aortic valve replacement (TAVR). The recently recommended cusp-overlap technique (COT) offers optimized fluoroscopic projections facilitating a precise ID. This single-center observational study aimed to investigate short-term clinical performance, safety, and efficacy outcomes in patients undergoing TAVR with self-expandable prostheses and application of COT in a real-world setting.Materials and methodsFrom September 2020 to April 2021, a total of 170 patients underwent TAVR with self-expandable devices and the application of COT, while 589 patients were treated from January 2016 to August 2020 with a conventional three-cusp coplanar view approach. The final ID and 30-day outcomes were compared after 1:1 propensity score matching, resulting in 150 patients in both cohorts.ResultsThe mean ID was significantly reduced in the COT cohort (−4.2 ± 2.7 vs. −4.9 ± 2.3 mm; p = 0.007) with an improvement of ID symmetry of less than 2 mm difference below the annular plane (47.3 vs. 57.3%; p = 0.083). The rate of new permanent pacemaker implantation (PPI) following TAVR was effectively reduced (8.0 vs. 16.8%; p = 0.028). While the fluoroscopy time decreased (18.4 ± 7.6 vs. 19.8 ± 7.6 min; p = 0.023), the dose area product increased in the COT group (4951 ± 3662 vs. 3875 ± 2775 Gy × cm2; p = 0.005). Patients implanted with COT had a shorter length of in-hospital stay (8.4 ± 4.0 vs. 10.3 ± 6.7 days; p = 0.007).ConclusionTranscatheter aortic valve replacement using the cusp-overlap deployment technique is associated with an optimized implantation depth, leading to fewer permanent conduction disturbances. However, our in-depth analysis showed for the first time an increase of radiation dose due to extreme angulations of the gantry to obtain the cusp-overlap view.