bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing intensity of deimatic behaviour in response to repeated simulated attacks: a case study on the mountain katydid (Acripeza reticulata)
Authors: Mourmourakis Faelan , De Bona Sebastiano , Umbers Kate D. L. 
Published: August 2022

Abstract

How and when deimatic behaviours are performed can change during encounters between predators and prey. Some predators attack repeatedly, investigating and manipulating prey, and in response, an individual’s deimatic behaviour may intensify or may diminish in favour of escaping. The presence of a resource can further force a trade-off between displaying and escaping. Here, we examined the intensity of the katydid’s deimatic behaviour, a visual display, the propensity of their escape response under repeated simulated attacks, and how these responses change in the presence of foraging resources. We found that display intensity increased with repeated simulated attacks and that females displayed at a greater intensity than males. The presence of their preferred food plant had no significant effect on display intensity, but reduced escape probability in both sexes. Some katydids were predictable in their display intensity and at the population level we found that strong display intensity is moderately repeatable. Overall, our results suggest that 1) display intensity increases with repeated attacks and might indicate a cost in performing at maximum intensity upon first attack, 2) deploying a deimatic display while feeding can reduce the need to flee a rich foraging patch and 3) some individuals are consistent in their display intensities. Future experiments that aim to determine causal mechanisms such as limitations to perception of predators, sensitisation to stimuli and physiological constraints to display intensity will provide necessary insight into how deimatic displays function.

Significance statement
Though often regarded as success or failure, interactions between predators and prey during the attack phase of a predation event are complex, especially when predators make repeated investigative attacks in quick succession. Our study shows that in mountain katydids, intensity of deimatic behaviour increases with repeated attacks, perhaps indicating that prey sensitise or that maximal displays during initial attacks carry high costs such as conspicuousness. The intensity of the display does not change with the introduction of a valuable food resource, but the probability of fleeing decreased, suggesting that displaying may reduce the opportunity costs of leaving a patch. We also show that individuals vary in the repeatability of their display, suggesting that deimatic display may be highly adaptable, nuanced and targeted.
Why empresses have more sons? Maternal instant social condition determines it
Authors: Li Yan-Peng , Ding Wei , Huang Zhi-Pang , Pan Ru-Liang , Li Na , Ren Guo-Peng , Cui Liang-Wei , Cai Qing-hua , Xiao Wen 
Published: August 2022

Abstract

Sexual selection echoed by the sex ratio is a critical issue in evolution and reproductive biology studies, and the second sex ratio (sex ratio at birth, SRB) is an important evaluation indicator for sex regulation. However, broad debates on sex ratio at birth exist due to the lack of a clear spatiotemporal genealogical database. This study explicitly tests the Trivers and Willard’s hypothesis stating that parents with good social conditions tend to show a male-biased SRB. Using a database of Chinese imperial families from 211BC to 1912 (2142 years) which avoids the spatiotemporal confusion of data thanks to its clear boundaries and long timespan, we found that a proportion of males at birth was 0.54. In particular, the results indicate that the empresses generated a significantly higher male-biased SRB than the concubines within the imperial harems (0.61 vs 0.53), while the SRB of concubines was not higher than ordinary people (0.53 vs 0.52). A significant difference of SRB before and after empress coronation (0.48 vs 0.65) was detected, indicating that the change to a higher social status is the leading cause of a biased SRB. These findings suggest that mothers with privileged instant social conditions tend to generate more boys than girls. In other words, a higher maternal social rank during the conception period, instead of rich resources, forms the primary mechanism regulating the SRB.

Significance statement
Adaptive sex ratio has been a debatable topic difficult to clearly verify since the publication of Trivers and Willard Hypothesis in 1973, which proposes that parents who have good conditions should produce more male offspring. The one reason is that the validity and sample size of the databases used contained unavoidable confounding noise, both genealogically and genetically. To overcome these issues, we specifically compiled a historical database of Chinese imperial families, which are characterized by a confined mating harem and unique eunuch system, guaranteeing biological and genetic purity with precise genealogical relationships and genetic linkages between the parents and the offspring. Thus, this is an extraordinary effort to clarify the hypotheses proposed by TWH and other hypotheses.
Drug-loaded PCL electrospun nanofibers as anti-pancreatic cancer drug delivery systems
Authors: Mitxelena-Iribarren Oihane , Riera-Pons Marc , Pereira Sheila , Calero-Castro Francisco José , Castillo Tuñón Juan Manuel , Padillo-Ruiz Javier , Mujika Maite , Arana Sergio 
Published: August 2022

AbstractCancer is one of the main causes of death worldwide, being pancreatic cancer the second deadliest cancer in Western countries. Surgery, chemotherapy and radiotherapy form the basis of pancreatic cancer’s current treatment. However, these techniques have several disadvantages, such as surgery complications, chemotherapy systemic side effects and cancer recurrence. Drug delivery systems can reduce side effects, increasing the effectivity of the treatment by a controlled release at the targeted tumor cells. In this context, coaxial electrospun fibers can increase the control on the release profile of the drug. The aim of this study was to encapsulate and release different anticancer drugs (5-Fluorouracil and Methotrexate) from a polymeric fiber mat. Different flows and ratios were used to test their effect on fiber morphology, FTIR spectrum, drug encapsulation and release. Good integration of the anticancer drugs was observed and the use of a desiccator for 24 h showed to be a key step to remove solvent remanence. Moreover, the results of this study demonstrated that the polymeric solution could be used to encapsulate and release different drugs to treat cancers. This makes coaxial electrospinning a promising alternative to deliver complex chemotherapies that involve more than one drug, such as FOLFIRINOX, used in pancreatic cancer treatment.
Combined sclerotherapy followed by surgical resection of a large extracranial venous malformation in a 14-month-old child: preoperative workup and technical note
Authors: Lavé Alexandre , Yilmaz Hasan , Rosi Andrea , Paun Luca , Patet Gildas , Bartoli Andrea 
Published: August 2022

Abstract

Introduction
Venous malformations affect around 2 per 10,000 newborn and are the most common type of congenital vascular malformation. They are always present at birth and are often misdiagnosed with hemangiomas. Accurate diagnosis and adequate targeted therapy through a multidisciplinary approach is advocated for a successful treatment, considering a combination of modalities in complex cases. We present here the workup and treatment of a venous malformation in a 14 month old child by combining a preoperative sclerotherapy with sodium tetradecyl sulfate (STS) followed by complete surgical excision respecting the calvarium.
Case presentation.
A large right extracranial fronto-parietal venous malformation and scalloping of the underlying calvarium, attached to the pericranium, surgically excised after preoperative sclerotherapy with STS in a 14-month-old child.

Results
The patient had an uneventful postoperative course with complete resection of the lesion, satisfying cosmetic appearance and no complications. Histopathological examination confirmed a venous malformation.

Conclusion
We demonstrated the workup and the rationale of the combined sclerotherapy followed by surgical resection of a large growing extracranial venous malformation. Preoperative direct contrast injection and sclerotherapy allowed to rule out significative extracranial to intracranial venous inflow and reduce blood loss for the surgical procedure, respectively. Complete removal of the malformation minimized the impact on future growth of the calvarium.
IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
Authors: Struckmeier Ann-Kristin , Radermacher Anne , Fehrenz Michael , Bellin Tamara , Alansary Dalia , Wartenberg Philipp , Boehm Ulrich , Wagner Mathias , Scheller Anja , Hess Jochen , Moratin Julius , Freudlsperger Christian , Hoffmann Jürgen , Thurner Lorenz , Roemer Klaus , Freier Kolja , Horn Dominik 
Published: August 2022

Abstract
Purpose
Strategies for Indolamine-2,3-dioxygenase 1 (IDO1) inhibition in cancer immunotherapy once produced encouraging results, but failed in clinical trials. Recent evidence indicates that immune cells in the tumour microenvironment, especially macrophages, contribute to immune dysregulation and therefore might play a critical role in drug resistance.

Methods
In this study, we investigated the significance of IDO1 expressing immune cells in primary tumours and corresponding lymph node metastases (LNMs) in oral squamous cell carcinoma (OSCC) by immunohistochemistry. The link between IDO1 and macrophages was investigated by flow cytometry in tumour tissue, healthy adjacent tissue and peripheral blood mononuclear cells (PBMCs). IDO1 activity (measured as Kynurenine/Tryptophan ratio) was assessed by ELISAs.

Results
High IDO1 expression in tumour-infiltrating immune cells was significantly correlated with advanced stages [Spearman’s rank correlation (SRC), p = 0.027] and reduced progression-free survival (multivariate Cox regression, p = 0.034). IDO1 was significantly higher expressed in PBMCs of patients in advanced stages than in healthy controls (ANOVA, p < 0.05) and IDO1+ macrophages were more abundant in intratumoural areas than peritumoural (t test, p < 0.001). IDO1 expression in PBMCs was significantly correlated with IDO1 activity in serum (SRC, p < 0.05). IDO1 activity was significantly higher in patients with LNMs (t test, p < 0.01).

Conclusion
All in all, IDO1 expressing immune cells, especially macrophages, are more abundant in advanced stages of OSCC and are associated with reduced progression-free survival. Further investigations are needed to explore their role in local and systemic immune response. The IDO1 activity might be a suitable biomarker of metastasis in OSCC patients.
Disappearance of an ecosystem engineer, the white-lipped peccary (Tayassu pecari), leads to density compensation and ecological release
Authors: Whitworth Andrew , Beirne Christopher , Basto Arianna , Flatt Eleanor , Tobler Mathias , Powell George , Terborgh John , Forsyth Adrian 
Published: August 2022

AbstractGiven the rate of biodiversity loss, there is an urgent need to understand community-level responses to extirpation events, with two prevailing hypotheses. On one hand, the loss of an apex predator leads to an increase in primary prey species, triggering a trophic cascade of other changes within the community, while density compensation and ecological release can occur because of reduced competition for resources and absence of direct aggression. White-lipped peccary (Tayassu pecari—WLP), a species that typically co-occurs with collared peccary (Pecari tajacu), undergo major population crashes—often taking 20 to 30-years for populations to recover. Using a temporally replicated camera trapping dataset, in both a pre- and post- WLP crash, we explore how WLP disappearance alters the structure of a Neotropical vertebrate community with findings indicative of density compensation. White-lipped peccary were the most frequently detected terrestrial mammal in the 2006–2007 pre-population crash period but were undetected during the 2019 post-crash survey. Panthera onca (jaguar) camera trap encounter rates declined by 63% following the WLP crash, while collared peccary, puma (Puma concolor), red-brocket deer (Mazama americana) and short-eared dog (Atelocynus microtis) all displayed greater encounter rates (490%, 150%, 280%, and 500% respectively), and increased in rank-abundance. Absence of WLP was correlated with ecological release changes in habitat-use for six species, with the greatest increase in use in the preferred floodplain habitat of the WLP. Surprisingly, community-weighted mean trait distributions (body size, feeding guild and nocturnality) did not change, suggesting functional redundancy in diverse tropical mammal assemblages.
First report of a chrysovirus infecting a member of the fungal genus Ilyonectria
Authors: Pielhop Tom P. , Popp Carolin , Knierim Dennis , Margaria Paolo , Maiß Edgar 
Published: August 2022

AbstractThe fungus Ilyonectria pseudodestructans belongs to the family Nectriaceae and was found to be part of the endophytic microbiome of apple trees (Malus x domestica, Borkh.) with apple replant disease (ARD). After dsRNA extraction, a mycoviral infection became evident. Here, we report the identification of a new virus, tentatively named “Ilyonectria pseudodestructans chrysovirus 1” (IpCV1), as the first member of the proposed new species “Alphachrysovirus ilyonectriae” within the genus Alphachrysovirus. This is the first report of a chrysovirus infecting a member of the fungal genus Ilyonectria. IpCV1 has a tripartite dsRNA genome with a total length of 8944 bp. The segments are 3439 bp, 2850 bp, and 2655 bp in length, and each dsRNA carries a single ORF. The encoded viral proteins are a 125.92-kDa RNA-dependent RNA polymerase, a 100.75-kDa coat protein, and one protein of unknown function with a predicted molecular mass of 93.04 kDa. The 5´ and 3´ UTRs are comparatively short and are 79 to 91 bp and 62 to 148 bp in length, respectively. This study provides the basis for further investigations of the impact of IpCV1 on its host and the etiology of ARD.
Minimality and comparison of sets of multi-attribute vectors
Authors: Toffano Federico , Wilson Nic 
Published: August 2022

AbstractIn a decision-making problem, there is often some uncertainty regarding the user preferences. We assume a parameterised utility model, where in each scenario we have a utility function over alternatives, and where each scenario represents a possible user preference model consistent with the input preference information. With a set $$A$$
A
of alternatives available to the decision-maker, we can consider the associated utility function, expressing, for each scenario, the maximum utility among the alternatives. We consider two main problems: firstly, finding a minimal subset of $$A$$
A
that is equivalent to it, i.e., that has the same utility function. We show that for important classes of preference models, the set of possibly strictly optimal alternatives is the unique minimal equivalent subset. Secondly, we consider how to compare $$A$$
A
to another set of alternatives $$B$$
B
, where $$A$$
A
and $$B$$
B
correspond to different initial decision choices. This is closely related to the problem of computing setwise max regret. We derive mathematical results that allow different computational techniques for these problems, using linear programming, and especially, with a novel approach using the extreme points of the epigraph of the utility function.
Safe Pareto improvements for delegated game playing
Authors: Oesterheld Caspar , Conitzer Vincent 
Published: August 2022

AbstractA set of players delegate playing a game to a set of representatives, one for each player. We imagine that each player trusts their respective representative’s strategic abilities. Thus, we might imagine that per default, the original players would simply instruct the representatives to play the original game as best as they can. In this paper, we ask: are there safe Pareto improvements on this default way of giving instructions? That is, we imagine that the original players can coordinate to tell their representatives to only consider some subset of the available strategies and to assign utilities to outcomes differently than the original players. Then can the original players do this in such a way that the payoff is guaranteed to be weakly higher than under the default instructions for all the original players? In particular, can they Pareto-improve without probabilistic assumptions about how the representatives play games? In this paper, we give some examples of safe Pareto improvements. We prove that the notion of safe Pareto improvements is closely related to a notion of outcome correspondence between games. We also show that under some specific assumptions about how the representatives play games, finding safe Pareto improvements is NP-complete.
Predicting invasive consumer impact via the comparative functional response approach: linking application to ecological theory
Authors: Landi Pietro , McCoy Michael W. , Vonesh James R. 
Published: August 2022

AbstractThe Comparative Functional Response Approach (CFRA) was developed to provide a practical methodology by which short-term experiments can be used to forecast the longer-term impacts of a potential invading consumer. The CFRA makes inferences about potential invader impact based on comparisons of the functional responses of invader and native consumers on native resources in a common experimental venue. Application of the CFRA and derivative approaches have proliferated since it was introduced in 2014. Here we examine the conceptual foundations of the CFRA within the context of basic Lotka–Volterra consumer-resource theory. Our goals are to assess whether core predictions of the CFRA hold within this framework, to consider the relative importance of background mortality and consumer assimilation efficiency in determining predator impact, and to leverage this conceptual framework to expand the discussion regarding stability and long term consumer and resource dynamics. The CFRA assertion that consumers with a higher functional response will have larger impacts on resources only holds as long as all other parameters are equal, but basic theory indicates that predator impacts on prey abundance and stability will depend more on variation in conversion efficiency and background mortality. While examination of the CFRA within this framework highlights limitations about its current application, it also points to potential strengths that are only revealed when a theoretical context is identified, in this case the implications for stability and conceptual links to competition theory.
The right tree in the right place? A major economic tree species poses major ecological threats
Authors: Bellingham P. J. , Arnst E. A. , Clarkson B. D. , Etherington T. R. , Forester L. J. , Shaw W. B. , Sprague R. , Wiser S. K. , Peltzer D. A. 
Published: August 2022

AbstractTree species in the Pinaceae are some of the most widely introduced non-native tree species globally, especially in the southern hemisphere. In New Zealand, plantations of radiata pine (Pinus radiata D. Don) occupy c. 1.6 million ha and form 90% of planted forests. Although radiata pine has naturalized since 1904, there is a general view in New Zealand that this species has not invaded widely. We comprehensively review where radiata pine has invaded throughout New Zealand. We used a combination of observational data and climate niche modelling to reveal that invasion has occurred nationally. Climate niche modelling demonstrates that while current occurrences are patchy, up to 76% of the land area (i.e. 211,388 km2) is climatically capable of supporting populations. Radiata pine has mainly invaded grasslands and shrublands, but also some forests. Notably, it has invaded lower-statured vegetation, including three classes of naturally uncommon ecosystems, primary successions and secondary successions. Overall, our findings demonstrate pervasive and ongoing invasion of radiata pine outside plantations. The relatively high growth rates and per individual effects of radiata pine may result in strong effects on naturally uncommon ecosystems and may alter successional trajectories. Local and central government currently manage radiata pine invasions while propagule pressure from existing and new plantations grows, hence greater emphasis is warranted both on managing current invasions and proactively preventing future radiata pine invasions. We therefore recommend a levy on new non-native conifer plantations to offset costs of managing invasions, and stricter regulations to protect vulnerable ecosystems. A levy on economic uses of invasive species to offset costs of managing invasions alongside stricter regulations to protect vulnerable ecosystems could be a widely adopted measure to avert future negative impacts.
Farmers adapt to climate change irrespective of stated belief in climate change: a California case study
Authors: Petersen-Rockney Margiana 
Published: August 2022

AbstractFarmers are front-line workers managing climatic change. As in many parts of the world, climate change in northern California is threatening natural resource-dependent communities by exacerbating droughts, heatwaves, and wildfires. This article draws on ethnographic methods, including 108 interviews with crop and livestock farmers and key informants, to query climate change experience, belief, and response in rural northeastern California. I find that farmers recognize and describe climate changes that match the meteorologic evidence of anthropogenic climate change, but attribute these changes to weather cycles and harsh geographies. However, irrespective of their belief in anthropogenic climate change, farmers implement climate adaptations—many of these practices with mitigation co-benefits, bolstering growing evidence that climate change belief and action are not tightly coupled. To accelerate farmer adaptation, this work suggests that policy and programming focus on actions and outcomes, rather than reshaping belief.