bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation of Soil Maps Permeability, Case Study in Two Cantons of Loja Province, Ecuador
Authors: Marín Jorge Andrés Espinosa , Rivera Diego 
Published: October 2022

Abstract
The generation of permeability maps is based on the analysis and interpretation of geology, environmental morphology, land use, and slope, which enables the selection of sampling areas with similar characteristics. The method represents the integration of the physical characteristics of the study area and then determines the infiltration capacity differences in the most representative geopedologic units.

In determining the basic data, minidisc infiltrometers were used to perform seventy-two infiltration tests in different types of soils with varying organic matter content, texture, soil structure, and vegetation cover, which showed the spatial variability that exists in two cantons of Loja province, Ecuador. In addition, it was observed that the infiltration rate depended mainly on the content of the organic matter in the soil and is consistent with information collected on permeability worldwide.

In this study, generated pedotransfer functon(FTP) coefficient of determination R2 0.78, the determination of the coefficient indicates a satisfactory estimate of the permeability with the variables that were analyzed; in addition, the methodology for assessing the permeability was suitable for the conditions of this investigation. For this reason, the method described here should be tested in other areas of the country with a greater number of field trials and in as with more variable contents of organic matter and soil textural classes.
Identification of fruit fly (Tephritidae) pupae parasitized by Hymenoptera parasitoids
Authors: de Almeida Tiago Tognolli , Roel Antonia Railda , de Oliveira Carina Elisei , Rocha Bruno Fines , Dias Angélica Maria Penteado Martins 
Published: October 2022

Abstract

One of the major problems in orchards is the presence of Tephritidae fly maggots, especially in Mirtaceae species. Various biological control tools include the use of Hymenoptera parasitoids, which naturally control fly populations. However, identification of the host species of parasitoids is challenging, because only the puparium remains after the parasitoid hatches. Therefore, the aim of this work was to determine the host species of Hymenoptera parasitoids, through the puparium. Host species were identified by amplification and sequencing of cytochrome C oxidase subunit I (COI) of mitochondrial DNA. The results of the present study show that COI DNA sequencing was able to reliably identify host pupae to the genus level, allowing the identification of the Anastrepha genus in this study. This suggests that this method can be used to identify agriculturally relevant host pupae, since this genus has already been described as a parasite of Campomanesia adamantium. Knowledge of the species that cause damage to crop, and their parasitoids is extremely important to study the biological and ecological aspects of these pests and their control. In this way, our results can contribute to the development of alternatives to the use of insecticides, reducing the use of chemical agents in crop production and minimizing the harmful effects on other insect species.
Anti-Hyperuricemia Mechanism of Anserine Based on the Gut-Kidney Axis: Integrated Analyses of Metagenomic and Metabolomic
Authors: Halimulati Mairepaiti , Wang Ruoyu , Aihemaitijiang Sumiya , Huang Xiaojie , Ye Chen , Zhang Zongfeng , He Lixia , Zhu Wenli , Zhang Zhaofeng 
Published: October 2022

Abstract
Background
Due to the increasing prevalence of hyperuricemia and the lack of effective prevention and treatment methods, the development of safe and effective intervention substances has become a public health issue. Herein, the therapeutic ability of anserine, a bioactive peptide, was validated through a comprehensive multi-omics analysis of a rat model of hyperuricemia.
Methods
A total of 60 male Sprague–Dawley rats (180–220 g) were randomly divided into six groups (n = 10): normal control group (NC group), hyperuricemia group (HUA group), allopurinol group (Allo group, 10 mg/kg·bw allopurinol), three anserine groups (Ans1, Ans10 and Ans100 groups were treated with 1 mg/kg·bw, 10 mg/kg·bw and 100 mg/kg·bw anserine, respectively). Uric acid, liver and kidney function-related indexes and renal histology were detected. Five kidneys, intestinal feces and urine samples were selected from each group and the differences of uric-acid-related transporters, gut microbes and urine metabolites were detected and analyzed by western blot, metagenomic and UPLC-MS methods, respectively. Non-omics data was calculated using One-way analysis of variance (ANOVA) by SPSS 25.0 software. The omics data were analyzed using R software (version 4.1.1). The correlation between gut microbiota and metabolites was analyzed using the Pearson correlation coefficient method, with a significance threshold of P < 0.05.
Results
Anserine was observed to improve liver and kidney function and modulate urate-related transporter expressions in the kidneys. Urine metabolomics showed that 15 and 9 metabolites were significantly increased and decreased, respectively, in hyperuricemia rats after the anserine intervention. Key metabolites such as fructose, xylose, methionine, erythronic acid, glucaric acid, pipecolic acid and trans-ferulic acid were associated with ameliorating kidney injury. Additionally, anserine regularly changed the gut microbiota, thereby ameliorating purine metabolism abnormalities and alleviating inflammatory responses. The integrated multi-omics analysis indicated that Saccharomyces, Parasutterella excrementihominis and Emergencia timonensis were strongly associated with key differential metabolites.
Conclusions
We proposed that anserine improved hyperuricemia via the gut–kidney axis, highlighting its potential in preventing and treating hyperuricemia.
Encircling scleral buckling for the treatment of retinal detachment: Development in indication and outcome within the last decade
Authors: Iby Johannes , Hollaus Marlene , Eibenberger Katharina , abela-formanek claudette , Reiter Gregor , Pollreisz Andreas , Schmidt-Erfurth Ursula , Georgopoulos Michael , Sacu Stefan 
Published: October 2022

Abstract
Background/Objectives: To evaluate the use of encircling scleral buckling for treating retinal detachment (RD) and its complications as well as success rate within the last decade.
Subjects/Methods: This retrospective observational study included 163 eyes receiving encircling scleral buckling (ESB) or ESB combined with vitrectomy (SBV) between 2009 and 2018. Main outcome measures include usage rate of ESB and SBV, indications and mean age. Furthermore, intra-/postoperative complications, intraocular tamponades as well as influences on functional outcome (BCVA) and central retinal thickness (CRT) were evaluated. For statistical analysis, patients were divided into five groups of two years each.
Results: ESB and SBV surgeries decreased from initially 32% of all RD-operations between 2009-2010 to 9.2% between 2017-2018 (p<0.001, ANOVA). Mean age at surgery differed significantly over the years from 56.9±17.1 between 2009-2010 to 37.6±28.3 between 2017-2018 (p<0.001, ANOVA). Functional outcome after a mean follow-up time of 43.1±39.5 months increased from 1.34±0.88 logMAR at baseline (BSL) to 0.99±0.87 logMAR at the last follow-up visit. Significant influencing factors on BCVA were BCVA at BSL (p<0.001), duration of RD (p=0.01) and lens status (pseudophakic > phakic > aphakic, p<0.001). Significant impacts on CRT were surgical technique (SBV > ESB, p=0.017) and macula on/off (off > on, p=0.036).
Conclusion: After an initial decrease, a rebound in ESB and SBV surgeries was noticed, with a significant reduction in mean age. Indications for surgery shifted over our observational period. No significant differences in functional outcome as well as intra- and postoperative complications were observed.
Subgroups of mild cognitive impairment based on cognitive function among Chinese older adults: a latent classes analysis
Authors: Zhou Yi , Lin Rong , Yan Yuanjiao , Luo Yuting , Cai Zhenzhen , Zhu Kaiyan , Huang Chenshan , Wang Yunxian , Xu Yifei , Chao Yueqi , Zhang Chufan , Li Hong 
Published: October 2022

Abstract
Background: Due to the heterogeneity of MCI, the key points of non-drug therapies cannot be determined. Exploring the characteristics among different MCI subgroups would therefore be beneficial in guiding the development of non-drug therapies. In the present study, weexplored subgrouping of older Chinese adults with MCI based on cognitive function and analyzed the characteristics of the resulting subgroups.
Methods: A cross-sectional study was conducted between October 2018 and January 2022. The study enrolled a total of 1017 participants with MCI in Fujian, East China. Participants underwent a comprehensive neuropsychological test assessing memory, language, attention, and executive function and completed a questionnaire examining socioeconomic and clinical variables.Neuropsychological test scores were transformed to z-scores, which were then examined using latent class analysis. Correlations of socioeconomic and clinical variables with MCI subgroups were assessed using multinomial logistic regression analysis.
Results: Three MCI subgroups were identified: (1) false-positive MCI (56.64%); (2) early MCI (36.28%); and (3) late MCI (7.08%). Age, data sources, marriage status, living status, and participation in intellectual activities differed significantly across the three MCI subgroups (P<0.05). Compared with the false-positive MCI group, participants with late MCI were less likely to participate in intellectual activity and more likely to live in a nursing home.
Conclusions: Older Chinese adults with MCI can be classified into subgroups based on cognitive function. A large proportion of participants were classified in the false-positive MCI group, suggesting that conventional diagnostic criteria are susceptible to false-positive errors, resulting in patients being misdiagnosed as MCI in China. And further research to define the characteristics of different MCI subgroups could facilitate the development of non-drug therapies for MCI.
ZMYND8 as a novel diagnostic and prognostic biomarker in Glioma
Authors: Xiao Huanqin , Xie Shoucheng , Zheng Shaoqiu , Lu Shanming , Liu Qinghua , Liu Kun , Zhong Ying , Luo Haiyan , Luo Wenjuan , Zhu Wenbiao 
Published: October 2022

Abstract
Background: Glioma is the most common and lethal tumor and its classification depends mainly on molecular parameters such as IDH, ATRX. However, the further classification of glioma is still uncertain. The purpose of this study was to evaluate the status of ZMYND8 expression and its diagnosis and prognostic value in adult patients of glioma.
Methods: We detected IDH1-R132H, ATRX and ZMYND8 expression by using immunohistochemistry in 104 glioma patients and retrospectively evaluated the data to find out the relationship between ZMYND8 and other clinical features in this study.
Results: Our results showed high expression of ZMYND8 is strongly associated with high-grade glioma (P<0.001) and worse overall survival (P<0.05). ATRX loss is closely correlated with ZMYND8 (P<0.05). These patients were divided into three groups and the distribution of patients’ age was significantly different. Patients combined IDH1-132H mutation with ATRX loss had a longer overall survival. Multivariate cox regression analysis demonstrated that IDH1-132H was an independent indicator of OS and PFS in glioma, and ATRX was an independent indicator of OS, ZMYND8 was an independent indicator of PFS.
Conclusion: The new model might help to predict the outcome of patients with glioma.
Dynamics of Flow Redistribution and Vascular Remodeling in Response to Selected Vessel Ablation
Authors: Gruionu Gabriel , Baish James , McMahon Sean , Blauvelt David , Gruionu Lucian G. , Lenco Mara Onita , Vakoc Benjamin J. , Padera Timothy P. , Munn Lance L. 
Published: October 2022

Abstract
Overly dense microvascular networks are treated by selective reduction of vascular elements. Inappropriate manipulation of microvessels could result in loss of host tissue function or a worsening of the clinical problem. Here, an experimental and computational model were developed to predict skin microvascular network remodeling in response to selective vessel interruption via multi-photon laser ablation without damage of the host tissue. The microvasculature was imaged non-invasively by bright-field and multi-photon laser microscopy, and Optical Coherence Tomography pre-ablation and up to 30 days post-ablation. A theoretical model of network remodeling was developed to compute intravascular pressure and identify vessels most sensitive to changes in flow direction. Immediately post-ablation, the average artery and vein diameters increased by 14% and 23%, respectively. The maximum arterial remodeling was 2.5x vs. 3.3x for a vein at day 20 post-ablation. By day 30, the average artery diameter remained 11% increased whereas the vein diameter returned to near preablation value. Venous blood flow was restored in the same location while arterial blood was redistributed through remodeling of collateral circulation with minimum angiogenesis. The theoretical model predicts that the vessels most likely to act as collaterals after flow disruption are those most sensitive to distant changes in pressure.
Experimental research on gas‒liquid dispersion in a stirred tank by a novel long‒short blades agitator
Authors: Wu Yongjun , Luo Peicheng , Chen Shifu 
Published: October 2022

Abstract
We used vertical short blades (SBs) and two pitched SBs with the inclined angles of the SBs from 60° to 45°, and compared the gas holdup, bubble size and interfacial area measured by the electrical conductivity probe technique when the agitator was operated in the down‒pumping and up‒pumping modes. Results show that higher gas holdup with large bubble size in the upper part and lower gas holdup but with small bubble size in the lower part of the tank. The effective fluid exchange between the radial flow generated by the long blades (LBs) and the strong axial flow generated by the SBs redistribute the bubbles effectively in the whole stirred tank. The gas phase is more evenly distributed in the whole tank with higher local gas holdup when the rotating speed is high enough. In the case of up‒pumping mode, the 45U impeller can further improve the gas‒liquid interface area. The correlation of power input and rotating speed on gas holdup is fitted.
Indirect evaluation of the swelling-shrinkage potential of Bentonite soil through analysis of the stress-strain behavior of its stabilized sample with cement and epoxy resin in the durability process
Authors: Soltaninejad Sanaz , Marandi Seyed Morteza 
Published: October 2022

Abstract

Bentonite soil containing predominantly Montmorillonite minerals has the highest tendency to absorb water and swell. No study has been done yet to stabilize Bentonite soil to last against successive wetting and drying cycles. In this research, Bentonite soil with approximately 45 wt% Montmorillonite mineral of the total amount was stabilized with cement and epoxy resin additives by gradually increasing the ratio of epoxy resin to water to withstand six successive W/D cycles. The uniaxial tests were performed on the stabilized samples after curing and 24 h of soaking in the third and sixth cycles. The swelling-shrinkage potential of Bentonite soil was evaluated by analyzing their stress-strain behavior, and it was predicted indirectly by determining the strength parameters. The results showed that for different amounts of cement, the minimum ratio of epoxy resin to water added to Bentonite soil to last up to six cycles was equal to 1. Also, by stabilizing the Bentonite soil so that the total weight of the optimum moisture content was replaced with epoxy resin, the strength and rigidity attained the level of normal concrete, with the difference that the ductility was much more significant. The failure strain value increased by 32 times, and the plastic region of the stress-strain curve expanded over the wide strain interval with a length of about 5%. In order to overcome the swelling-shrinkage potential of Bentonite soil at the level on which no cracks developed during W/D cycles, the strength and ductility properties got to at least the mentioned level of stabilization.
Blends of cactus cladode powder with corn starch, milk proteins and gelatin: Rheological evaluation and application to a soup model
Authors: Chaloulos Panagiotis , Vasilopoulos Nikolaos , Mandala Ioanna 
Published: October 2022

Abstract
Cactus Cladodes (Opuntia ficus-indica) is a valuable source of dietary fibers. In this study, peeled cladode powder was produced by air drying at 40 oC and was characterized for its color, dietary fiber content and rheological behavior. Cladode powder aqueous suspensions of 3% w/w were prepared and the effect of protein (gelatin, sodium caseinate and whey protein) or salts (NaCl/ CaCl2) on the blend’s viscosity was investigated. Additionally, cladode powder was incorporated in a soup model, aiming at substituting corn starch. Our powder had an appealing green color, but its deterioration was fast when it was exposed to light. A shear-thinning behavior was observed in all cladode-protein mixtures, but viscosity values depended considerably on the protein type and the pH values. Notably, gelatin addition led to higher apparent viscosity of cladode powder at pH 6, suggesting interactions with cladode mucilage, but this effect was reversed at pH 4, below gelatin isoelectric point. The Ostwald-de Waele model successfully correlated viscosity-shear rates data, whereas Casson model presented a good fit mainly in starch containing systems. Corn starch substitution by cladode powder, in the soup model, led to lower consistency coefficient values. In soups the logarithmic mixing law was applied at different corn starch: cladode powder ratios to highlight their possible interactions. The values obtained diverged slightly downwards from the logarithmic mixing law.When purified mucilage was added -instead of cladode powder- the samples diverged slightly upwards from the logarithmic mixing law.
Chidamide as monotherapy and in combination with traditional chemotherapy in peripheral T-cell lymphoma：a systematic review and meta-analysis
Authors: yang yujing , yao guoli 
Published: October 2022

Abstract
Background:Traditional chemotherapy regimens are not ideal for the treatment of peripheral T-cell lymphoma(PTCL). Recent clinical data have shown Chidamide,a type of histone deacetylase inhibitors, as a new type of anti-tumor drug, have achieved remarkable results in the treatment of PTCL.Therefore, we performed a systematic literature review and meta-analysis to objectively assess the efficacy and safety for peripheral T-cell lymphoma treated with Chidamide alone or Chidamide combination with chemotherapy.
Methods:We searched systematically for studies from the databases of PubMed, Embase, and the Cochrane Library published were searched without language restriction from inception until June 2022.using the following combination of free-text terms linked by Boolean operators: “peripheral T-cell lymphoma”OR“PTCL”OR“angioimmunoblastic lymphoma”OR“anaplastic large cell lymphoma”OR“NK/T-cell lymphoma”AND“Chidamide”. The primary end points were complete remission and overall response rates, adverse events were the secondary end points.
Results: A total of 7 clinical trials including newly-diagnosed and relapsed or refractory PTCL patients were analyzed.The overall CR rate was 35.2%(95% CI, 24.2-48%, Figure 2). And the ORR was 65.8%(95% CI, 54.4-75.6%). Thrombocytopenia, anemia, neutropenia were the most common grade 3 and 4 AEs.
Conclusion: Chidamide is effective for PTCL, and its efficacy can be increased with the combination traditional chemotherapy.
Hydroxychloroquine modifies angiogenesis factors in primary progressive multiple sclerosis
Authors: Yong Heather Y.F. , Tottenham Isabelle , Silva Claudia , Koch Marcus , Camara-Lemarroy Carlos 
Published: October 2022

Abstract

In this study we investigated serum angiogenic markers of hydroxychloroquine (HCQ)-treated patients with primary-progressive multiple sclerosis (PPMS) from a phase II clinical trial. PPMS patients had higher levels of endothelin-1 (ETN-1), fibroblast growth factor-2 (FGF-2), granulocyte-colony stimulating factor (G-CSF), heparin binding epidermal-growth factor, and interleukin-8 compared to healthy controls. At 6 months, the angiogenic markers ETN-1, FGF-2, G-CSF, and vascular endothelial growth factor-A were significantly reduced; conversely, angiopoietin-2, endoglin, and leptin were increased. Angiogenic changes did not correlate with disability worsening, however changes were more profound in stable patients suggesting a possible treatment effect with HCQ.
Incidence, Management and Predictors of Chemotherapy-Induced Neutropenia among Adult Solid Cancer Patients at the University of Gondar Comprehensive and Specialized Hospital: A Retrospective Follow-up Study
Authors: Wondm Samuel , Tadesse Sumeya , Abebaw Dessie , Dagnew Samuel , Dagnew Ephrem , Belachew Eyayaw , Kebede Bekalu 
Published: October 2022

Abstract
Background
chemotherapy-induced neutropenia is the most well-known oncologic emergencies and the most common hematologic toxicity of chemotherapy. A few studies have been carried out to assess the incidence and management practice of chemotherapy-induced neutropenia in Ethiopia.
Objective
the study was conducted to assess incidence, management, and predictors of chemotherapy-induced neutropenia among adult solid cancer patients at the University of Gondar Comprehensive and Specialized Hospital (UOGCSH)
Methods
A hospital-based retrospective follow-up study was conducted among adult solid cancer patients attending between January 1, 2017, to February 30, 2021, at the oncology ward of UOGCSH. A structured data abstraction format was used to collect data from patients' medical charts. Data were analyzed using STATA version 14.2. Bivariate and multivariable logistic regression analysis was used to identify independent predictors of chemotherapy-induced neutropenia and P-value, < 0.05 was considered statistically significant. Analysis of variance was used to compare the difference in recovery time of neutropenia between different treatment regimens
Results
A total of 416 patients were included in the study with a mean age of the patient 50.56 ± 14.4 years. The cumulative incidence of neutropenia was 62.3% (95% CI 57.9–67.1) and 13% of them developed infections. Advanced stage of cancer, poor performance status, patients taking triple treatment modality, lower baseline white blood cell count, elevated lactated dehydrogenase, cisplatin-paclitaxel, doxorubicin-cyclophosphamide, doxorubicin-cyclophosphamide followed by four cycles of paclitaxel and patients with two or more comorbidities were found to be predictors for chemotherapy-induced neutropenia (P < 0.05). The use of filgrastim has significantly reduced the duration of neutropenia recovery time by 33.28 days (P = 0.0001) as compared to chemotherapy delay.
Conclusion
The incidence of neutropenia was common in solid cancer and it is multifactorial. Health care professionals should be aware of these risk factors and greater effort is needed to reduce the risk of neutropenia. Filgrastim was the main management for chemotherapy-induced of neutropenia and it was significantly reduced the duration of neutrophil recovery time.