bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health services use and depressive symptom scores among gay and bisexual men in Canada
Authors: Marbaniang Ivan , Rose Eric , Moodie Erica E. M. , Hart Trevor A. , Cox Joseph 
Published: September 2022

Abstract
Purpose
To evaluate the association between mental health services (MHS) use and depressive symptom scores among gay and bisexual men (GBM) and compare with heterosexual men in Canada.

Methods
We used data from the 2015–2016 cycles of the Canadian Community Health Survey. Depressive symptoms were assessed using the PHQ-9 questionnaire (prior two weeks). MHS consultations with any licensed mental health professional (prior year) were categorized as 0, 1, 2–11, ≥ 12. We fit linear regression models to quantify the associations between MHS use and PHQ-9 scores, with an interaction term for sexual identity (GBM and heterosexual men). Models were adjusted for socioeconomic and health-related indicators.

Results
Among 21,383 men, 97.3% self-identified as heterosexual and 2.7% as GBM. Compared to heterosexual men, GBM used any MHS (21% vs. 10%, p < 0.05) and consulted ≥ 2 health professionals for their mental health (6% vs. 2%, p < 0.05) in the preceding year more frequently. Overall, mean PHQ-9 scores were higher among GBM compared to heterosexual men (3.9 vs. 2.3, p < 0.05). Relative to no consultations, higher MHS use (2–11, ≥ 12 consultations) was associated with higher PHQ-9 scores (1.4–4.9 points higher). Associations between MHS use and PHQ-9 scores did not differ statistically between GBM and heterosexual men.

Conclusion
Our findings were inconclusive in demonstrating a difference between heterosexual men and GBM for the association between MHS use and PHQ-9 scores. However, GBM consistently had higher average PHQ-9 scores for every category of consultations. Considering the higher use of MHS and higher burden of depressive symptoms among GBM, more research is needed.
Examination of the temporal sequence between social media use and well-being in a representative sample of adults
Authors: Jarman Hannah K. , McLean Siân A. , Paxton Susan J. , Sibley Chris G. , Marques Mathew D. 
Published: September 2022

AbstractGiven insufficient prospective evidence for relationships between social media use and well-being among adults, the present study examined the temporal sequence between social media use and psychological distress and life satisfaction, and explored age and gender differences. A representative sample of adults (N = 7331; 62.4% women; Mage = 51.94; SD = 13.48; 15–94 years) were surveyed annually across four waves. Cross-lagged panel models demonstrated bidirectional relationships between social media use and well-being. Higher psychological distress and lower life satisfaction predicted higher social media use more strongly than the reverse direction, with effects particularly pronounced for the impact of psychological distress. Although the patterns of findings were relatively consistent across age and gender, results suggested that women and middle- and older-aged adults experience detrimental effects of social media use on well-being, which may drive subsequent increased use of social media. The bidirectional relationships suggest that adults who experience psychological distress or lower life satisfaction may seek to use social media as a way to alleviate poor well-being. However, paradoxically, this maladaptive coping mechanism appears to drive increased social media use which in turn can exacerbate poor well-being. Clinicians should be aware of these bidirectional relationships and work with clients towards replacing ineffective strategies with more helpful coping approaches. As this study used a simplistic measure of social media use, future research should address this limitation and explore nuanced relationships afforded by assessing specific social media activities or exposure to certain types of content.
On the rigidity of Souslin trees and their generic branches
Authors: Lamei Ramandi Hossein 
Published: September 2022

AbstractWe show it is consistent that there is a Souslin tree S such that after forcing with S, S is Kurepa and for all clubs $$C \subset \omega _1$$

C
⊂

ω
1

, $$S\upharpoonright C$$

S
↾
C

is rigid. This answers the questions in Fuchs (Arch Math Logic 52(1–2):47–66, 2013). Moreover, we show it is consistent with $$\diamondsuit $$
♢
that for every Souslin tree T there is a dense $$X \subseteq T$$

X
⊆
T

which does not contain a copy of T. This is related to a question due to Baumgartner in Baumgartner (Ordered sets (Banff, Alta., 1981), volume 83 of NATO Adv. Study Inst. Ser. C: Math. Phys. Sci., Reidel, Dordrecht-Boston, pp 239–277, 1982).
Size-dependent and -independent prey selection of dinoflagellates
Authors: García-Oliva Ovidio , Wirtz Kai 
Published: September 2022

AbstractMechanisticapproachestoplanktonfood-websoftenrelyonsize-basedmodels.Thesemodelsdescribe predator–preyrelationshipsbasedonpredator body or cell size. However, size-based representations of trophic relationships fail to encompass the diverse feeding behavior of dinoflagellates, which play an essential role in the food-web due to their abundance and ubiquity. Here, we introduce the specialization factor (s) as an effective trait, which aggregates over aspects of morphology, trophic strategy, and feeding behavior and quantifies the degree of specialization towards a specific prey size. We found that specialization to either the upper or lower edge of the prey size spectrum is connected to size independent trophic relations. As a result, dinoflagellates can be divided into three groups with distinct dependencies of optimal prey size on predator size: (1) mixotrophic engulfers specialized on small prey ($$s=-1$$

s
=
-
1

), (2) pallium feeders on large prey ($$s=1$$

s
=
1

), and (3) neutral feeders ($$s=0$$

s
=
0

) encompassing generalist engulfers and tube feeders. Our trait based approach elucidates the evolutionary significance of diverse feeding modes and specialization in dinoflagellates compared to phylogenetically older groups such as ciliates. It furthermore leads to a more accurate representation of trophic relationships of dinoflagellates in models and can provide, more generally, an efficient description of complex and diverse feeding relations in plankton food-webs.
Vertex results for the robust analysis of uncertain biochemical systems
Authors: Blanchini Franco , Colaneri Patrizio , Giordano Giulia , Zorzan Irene 
Published: September 2022

AbstractWe consider the problem of assessing the sensitivity of uncertain biochemical systems in the presence of input perturbations (either constant or periodic) around a stable steady state. In particular, we propose approaches for the robust sensitivity analysis of systems with uncertain parameters assumed to take values in a hyper-rectangle. We highlight vertex results, which allow us to check whether a property is satisfied for all parameter choices in the hyper-rectangle by simply checking whether it is satisfied for all parameter choices at the vertices of the hyper-rectangle. We show that, for a vast class of systems, including (bio)chemical reaction networks with mass-action kinetics, the system Jacobian has a totally multiaffine structure (namely, all minors of the Jacobian matrix are multiaffine functions of the uncertain parameters), which can be exploited to obtain several vertex results. We consider different problems: robust non-singularity; robust stability of the steady-state; robust steady-state sensitivity analysis, in the case of constant perturbations; robust frequency-response sensitivity analysis, in the presence of periodic perturbations; and robust adaptation analysis. The developed theory is then applied to gain insight into some examples of uncertain biochemical systems, including the incoherent feed-forward loop, the coherent feed-forward loop, the Brusselator oscillator and the Goldbeter oscillator.
Objectively combining climate sensitivity evidence
Authors: Lewis Nicholas 
Published: September 2022

AbstractRecent assessments of climate sensitivity per doubling of atmospheric CO2concentration have combined likelihoods derived from multiple lines of evidence. These assessments were very influential in the Intergovernmental Panel on Climate Change Sixth Assessment Report (AR6) assessment of equilibrium climate sensitivity, thelikelyrange lower limit of which was raised to 2.5 °C (from 1.5 °C previously). This study evaluates the methodology of and results from a particularly influential assessment of climate sensitivity that combined multiple lines of evidence, Sherwood et al. (Rev Geophys 58(4):e2019RG000678, 2020). That assessment used a subjective Bayesian statistical method, with an investigator-selected prior distribution. This study estimates climate sensitivity using an Objective Bayesian method with computed, mathematical priors, since subjective Bayesian methods may produce uncertainty ranges that poorly match confidence intervals. Identical model equations and, initially, identical input values to those in Sherwood et al. are used. This study corrects Sherwood et al.'s likelihood estimation, producing estimates from three methods that agree closely with each other, but differ from those that they derived. Finally, the selection of input values is revisited, where appropriate adopting values based on more recent evidence or that otherwise appear better justified. The resulting estimates of long-term climate sensitivity are much lower and better constrained (median 2.16 °C, 17–83% range 1.75–2.7 °C, 5–95% range 1.55–3.2 °C) than in Sherwood et al. and in AR6 (central value 3 °C,very likelyrange 2.0–5.0 °C). This sensitivity to the assumptions employed implies that climate sensitivity remains difficult to ascertain, and that values between 1.5 °C and 2 °C are quite plausible.
MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study
Authors: Vergroesen Joëlle E. , de Crom Tosca O. E. , van Duijn Cornelia M. , Voortman Trudy , Klaver Caroline C. W. , Ramdas Wishal D. 
Published: September 2022

Abstract
Purpose
To assess the association between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and the incidence of open-angle glaucoma (iOAG), as well as the association between iOAG and two other well-established diets in the Netherlands, i.e., the Mediterranean diet and Dutch dietary guidelines.

Methods
In the Rotterdam Study, participants were followed for iOAG since 1991, with intervals of approximately 5 years. A total of 170 participants developed iOAG during follow-up. Participants with iOAG were matched with healthy controls on age and sex in a case:control ratio of 1:5. The associations between food frequency questionnaire-derived diet adherences (baseline) and iOAG were analyzed using multivariable conditional logistic regression analyses. The associations between the diet adherences and intraocular pressure (IOP; a risk factor for OAG) were assessed using multivariable linear regression analyses.

Results
Greater adherence to the MIND diet was associated with a decreased iOAG risk (odds ratio [95% confidence interval]: 0.80 [0.66 to 0.96], for each 10-percent increase in adherence). Food component analyses showed that, in particular a higher intake of green leafy vegetables, berries and fish tended to be protective for iOAG. No significant associations were observed between adherence to the Mediterranean diet or Dutch dietary guidelines and iOAG. Moreover, none of the three examined diets were associated with IOP.

Conclusion
Adherence to the MIND diet was significantly associated with a lower incidence of OAG in contrast to adherence to the Mediterranean diet or the Dutch dietary guidelines. As this association was IOP-independent, the MIND diet may be particularly relevant for the prevention of neurodegeneration in the eye.
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
Authors: Lackie Rachel E. , de Miranda Aline S. , Lim Mei Peng , Novikov Vladislav , Madrer Nimrod , Karunatilleke Nadun C. , Rutledge Benjamin S. , Tullo Stephanie , Brickenden Anne , Maitland Matthew E. R. , Greenberg David , Gallino Daniel , Luo Wen , Attaran Anoosha , Shlaifer Irina , Del Cid Pellitero Esther , Schild-Poulter Caroline , Durcan Thomas M. , Fon Edward A. , Duennwald Martin , Beraldo Flavio H. , Chakravarty M. Mallar , Bussey Timothy J. , Saksida Lisa M. , Soreq Hermona , Choy Wing-Yiu , Prado Vania F. , Prado Marco A. M. 
Published: September 2022

AbstractThe predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in synucleinopathies, such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). Molecular chaperones play important roles in protein misfolding diseases and members of the chaperone machinery are often deposited in Lewy bodies. Here, we show that the Hsp90 co-chaperone STI1 co-immunoprecipitated α-synuclein, and co-deposited with Hsp90 and Hsp70 in insoluble protein fractions in two mouse models of α-synuclein misfolding. STI1 and Hsp90 also co-localized extensively with filamentous S129 phosphorylated α-synuclein in ubiquitin-positive inclusions. In PD human brains, STI1 transcripts were increased, and in neurologically healthy brains, STI1 and α-synuclein transcripts correlated. Nuclear Magnetic Resonance (NMR) analyses revealed direct interaction of α-synuclein with STI1 and indicated that the STI1 TPR2A, but not TPR1 or TPR2B domains, interacted with the C-terminal domain of α-synuclein. In vitro, the STI1 TPR2A domain facilitated S129 phosphorylation by Polo-like kinase 3. Moreover, mice over-expressing STI1 and Hsp90ß presented elevated α-synuclein S129 phosphorylation accompanied by inclusions when injected with α-synuclein pre-formed fibrils. In contrast, reduced STI1 function decreased protein inclusion formation, S129 α-synuclein phosphorylation, while mitigating motor and cognitive deficits as well as mesoscopic brain atrophy in α-synuclein-over-expressing mice. Our findings reveal a vicious cycle in which STI1 facilitates the generation and accumulation of toxic α-synuclein conformers, while α-synuclein-induced proteostatic stress increased insoluble STI1 and Hsp90.
Overexpression of INSM1, NOTCH1, NEUROD1, and YAP1 genes is associated with adverse clinical outcome in pediatric neuroblastoma
Authors: Metovic Jasna , Napoli Francesca , Osella-Abate Simona , Bertero Luca , Tampieri Cristian , Orlando Giulia , Bianchi Maurizio , Carli Diana , Fagioli Franca , Volante Marco , Papotti Mauro 
Published: September 2022

AbstractPediatric neuroblastoma is responsible for approximately 8–10% of pediatric tumors, and it is one of the leading causes of tumor-related deaths in children. Although significant progress has been made in the characterization of neuroblastoma in recent years, the mechanisms influencing the prognosis of neuroblastoma patients remain largely unknown. Our aim was to investigate if the major neuroendocrine-associated transcriptional drivers, including ASCL1, NEUROD1, DLL3, NOTCH1, INSM1, MYCL1, POU2F3 and YAP1 are correlated with specific clinical and pathological characteristics. We selected a retrospective series of 46 primary pediatric neuroblastoma, composed of 30 treatment-naïve and 16 post-chemotherapy cases. Gene expression levels were explored by means of quantitative real-time PCR. An increased expression of NOTCH1 (p = 0.005), NEUROD1 (p = 0.0059), and YAP1 (p = 0.0008) was found in stage IV tumors, while the highest levels of MYCL1 and ASCL1 were seen in stages IVS and III, respectively (p = 0.0182 and p = 0.0134). A higher level of NOTCH1 (p = 0.0079) and YAP1 (p = 0.0026) was found in cases with differentiating morphology, while high mitosis-karyorrhexis index cases demonstrated significantly lower levels of POU2F3 (p = 0.0277). High expression of NOTCH1 (p = 0.008), NEUROD1 (p = 0.026), INSM1 (p = 0.010), and YAP1 (p = 0.005) together with stage IV (p = 0.043) was associated with shorter disease-free survival. In summary, our data indicate that the assessment of gene expression levels of neuroendocrine-lineage transcription factors might help to identify neuroblastoma patients with the risk of relapse.
A multi-level methodology for the automated translation of a coreference resolution dataset: an application to the Italian language
Authors: Minutolo Aniello , Guarasci Raffaele , Damiano Emanuele , De Pietro Giuseppe , Fujita Hamido , Esposito Massimo 
Published: September 2022

AbstractIn the last decade, the demand for readily accessible corpora has touched all areas of natural language processing, including coreference resolution. However, it is one of the least considered sub-fields in recent developments. Moreover, almost all existing resources are only available for the English language. To overcome this lack, this work proposes a methodology to create a corpus for coreference resolution in Italian exploiting knowledge of annotated resources in other languages. Starting from OntonNotes, the methodology translates and refines English utterances to obtain utterances respecting Italian grammar, dealing with language-specific phenomena and preserving coreference and mentions. A quantitative and qualitative evaluation is performed to assess the well-formedness of generated utterances, considering readability, grammaticality, and acceptability indexes. The results have confirmed the effectiveness of the methodology in generating a good dataset for coreference resolution starting from an existing one. The goodness of the dataset is also assessed by training a coreference resolution model based on BERT language model, achieving the promising results. Even if the methodology has been tailored for English and Italian languages, it has a general basis easily extendable to other languages, adapting a small number of language-dependent rules to generalize most of the linguistic phenomena of the language under examination.
Comparison of two mesh-moving techniques for finite element simulations of galvanic corrosion
Authors: Harzheim Sven , Hofmann Martin , Wallmersperger Thomas 
Published: September 2022

AbstractGalvanic corrosion is a destructive process between dissimilar metals. The present paper presents a constructed numerical test case to simulate galvanic corrosion of two dissimilar metals. This test case is used to study the accuracy of different implementations to track the dissolving anode boundary. One technique is to numerically simulate a mesh displacement based on the prescribed displacement at the anode boundary. The second method is to adjust only the boundary elements. Re-meshing after a certain number of time steps is applied to both implementations. They produce similar results for an electrical and electrochemical field problem. This work shows that mesh smoothing does not result in higher accuracy when modeling a moving anode front. Adjusting only the boundary elements is sufficient when frequent re-meshing is used.
Prevalence of engagement and frequency of non-suicidal self-injury behaviors in adolescence: an investigation of the longitudinal course and the role of temperamental effortful control
Authors: Esposito Concetta , Dragone Mirella , Affuso Gaetana , Amodeo Anna Lisa , Bacchini Dario 
Published: September 2022

AbstractNon-suicidal self-injury (NSSI) is among the most frequent maladaptive behaviors reported in adolescence, with prevalence rates around 18–22% in community samples worldwide. The onset of NSSI typically occurs between early and middle adolescence, with a peak during middle adolescence (14–15 years) and a subsequent decline during late adolescence. This study investigated the growth curves of NSSI across four years during adolescence, analyzing simultaneously the probability of engagement in NSSI at least once (i.e., prevalence) and the frequency of engagement once initiated (i.e., severity). Furthermore, the study examined the predicting role of effortful control on NSSI over time (time-varying effects), net of other key risk factors for NSSI, such as anxiety-depression and bullying victimization. A sample of 430 Italian adolescents enrolled in Grade 9 at baseline was involved in the study. Based on the Latent Growth Curve Zero-inflated Poisson methodology, the results indicated a negative quadratic trend of both NSSI prevalence, with an increase between T1 and T3 followed by a decrease in the subsequent wave, and NSSI frequency once initiated, with a peak at T2 followed by a decline over time. The results also showed that adolescents who reported low effortful control abilities had a heightened probability of involvement in NSSI at each time point, whereas no significant association was found with NSSI frequency once initiated. Findings from this study offer important insights into the developmental course of NSSI and point out the need for future in-depth investigations of the mechanisms that might underlie NSSI prevalence and severity throughout adolescence.
Global declarations on electric vehicles, carbon life cycle and Nash equilibrium
Authors: Bakhtyar Baher , Qi Zhang , Azam Muhammad , Rashid Salim 
Published: September 2022

AbstractUniversal environmental policies adopt strategies that enhance and encourage the production and usage of electric vehicles (EVs). Universal cooperation is evident in the framework of agreements or protocols so as to successfully lead countries towards the predetermined goals. The question is whether this trend can reduce global warming or CO2 emissions worldwide. By adopting game theory, this study analyses electricity carbon life cycle in leading EV countries. Results show that although the spread of EVs in Europe and the USA can mitigate carbon emissions, the production and use of electric vehicles in some countries, such as China and India, become a new source of such emissions. This reverse effect is due to the emission of greenhouse gases from electricity sources in these countries. Game theory also suggests that countries with unclean electricity sources should reconsider their plans to produce and use EVs. This study confirms that although carbon emission and global warming are global problems, regional and local policies can be substituted with a single comprehensive approach for an effective means of CO2 emission reduction.
Graphical abstract
Statistical shape modelling of the thoracic spine for the development of pedicle screw insertion guides
Authors: Wai Gordon , Rusli Wan , Ghouse Shaaz , Kieser David C. , Kedgley Angela , Newell Nicolas 
Published: September 2022

AbstractSpinal fixation and fusion are surgical procedures undertaken to restore stability in the spine and restrict painful or degenerative motion. Malpositioning of pedicle screws during these procedures can result in major neurological and vascular damage. Patient-specific surgical guides offer clear benefits, reducing malposition rates by up to 25%. However, they suffer from long lead times and the manufacturing process is dependent on third-party specialists. The development of a standard set of surgical guides may eliminate the issues with the manufacturing process. To evaluate the feasibility of this option, a statistical shape model (SSM) was created and used to analyse the morphological variations of the T4–T6 vertebrae in a population of 90 specimens from the Visible Korean Human dataset (50 females and 40 males). The first three principal components, representing 39.7% of the variance within the population, were analysed. The model showed high variability in the transverse process (~ 4 mm) and spinous process (~ 4 mm) and relatively low variation (< 1 mm) in the vertebral lamina. For a Korean population, a standardised set of surgical guides would likely need to align with the lamina where the variance in the population is lower. It is recommended that this standard set of surgical guides should accommodate pedicle screw diameters of 3.5–6 mm and transverse pedicle screw angles of 3.5°–12.4°.