bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic reliability of structures equipped with LIR‐DCFP bearings in terms of superstructure ductility and isolator displacement
Authors: Auad Gaspar , Castaldo Paolo , Almazán José L. 
Published: August 2022

AbstractThis research deals with the seismic reliability of non‐linear base‐isolated structures equipped with Lateral Impact Resilient Double Concave Friction Pendulum (LIR‐DCFP) devices. Specifically, exceeding probabilities within the reference lifetime are assessed with respect to both superstructure ductility and isolator displacement demand. The innovative LIR‐DCFP bearing has an improved inner slider with an internal gap and is capable to reduce adverse effects of the lateral impact between the inner slider and the restraining rims. The dynamic behavior of the superstructure is represented by a simplified one‐degree‐of‐freedom model describing its lateral response. The isolation system is characterized by a model based on rigid body dynamics also including the lateral impact behavior. A wide parametric analysis is developed for several system properties considering the friction coefficients as relevant random variables. Different sets of natural seismic records able to match conditional spectra for a site in Riverside (California) were selected to consider the aleatory uncertainties of the seismic input. Incremental dynamic analyses were performed to determine the statistics of significant engineering demand parameters and compute probabilities exceeding specific limit states to define fragility curves. Finally, employing seismic hazard curves, the seismic reliability of isolated structures was evaluated. For increasing values of the internal gap, structures equipped with LIR‐DCFP devices exhibit better seismic performance with respect to classical DCFP bearings with same size, especially, if the superstructure is designed to behave essentially elastic when the lateral capacity of the isolation level is not reached, or the hardening post‐yield stiffness of the superstructure is relatively high. Reductions up to 20% in the exceeding probabilities within 50 years related to the ductility demand are achievable using the suggested LIR‐DCFP isolator.
Synthesis of a novel type of high‐efficiency boron‐containing Schiff base flame retardant for epoxy resin
Authors: He Tingxiang , Guo Junhong , Qi Chengxia , Feng Rui , Yang Baoping , Zhou Yingping , Tian Li , Cui Jinfeng 
Published: August 2022

AbstractBoron‐containing Schiff base flame retardant ((E)‐2‐([2,4‐dihydroxybenzylidene]amino)ethyl dihydrogen borate (B‐HIBD) was prepared easily and successfully. Thermogravimetric analysis (TGA) showed that when the additive amount was only 3 wt%, the introduction of B‐HIBD significantly improved the thermal stability of epoxy resin (EP) composites. The cone calorimeter test showed that compared with pure EP, the peak of heat release rate (PHRR), total heat release (THR), smoke production rate (SPR)，total smoke production (TSP) ，and the releasing of CO for 3 wt% B‐HIBD/EP reduced by 58.2, 18.3, 65.9, 51.2, and 28.4%, respectively, showing that B‐HIBD could significantly enhance the fire safety of EP composites. This promotion has been embodied not only in the catalysis function of the Schiff base group containing benzene ring but also in borate participating in the carbon‐forming process, promoting the dehydration and carbonization of the EP surface and delaying the transfer of mass and heat in the combustion process, which enhance performance for flame retardant. So it is an efficient strategy to develop a novel type of high‐efficiency boron‐containing Schiff base flame retardant to improve the fire safety for EP.
The public health implications of gentrification: tick‐borne disease risks for communities of color
Authors: Halsey Samniqueka J , VanAcker Meredith C , Harris Nyeema C , Lewis Kaleea R , Perez Lisette , Smith Genee S 
Published: August 2022

Gentrification operates as a social driver of health that can increase tick‐borne disease (TBD) risk for communities of color through either population displacement or land‐use change. Research on the emergence of TBDs in urban environments has primarily focused on the ecological processes of urban landscapes that facilitate favorable habitats for host reservoirs and tick vectors. However, neglecting to view infectious disease risk from a socioecological framework will continue to result in policies and planning that disadvantage communities of color. Using Lyme disease as a case study, we integrated elements of environmental epidemiology, ecology, public health, and urban planning to propose pathways of gentrification as a socioecological process with public health implications. By drawing connections between urban ecology, urban planning, and environmental racism, we seek to bring awareness to disease ecologists, policy makers, and public health managers on the potential role of gentrification as a driver of tick‐borne pathogen exposure.Front Ecol Environ 2022;
Study on dietary intake, risk assessment, and molecular toxicity mechanism of benzo[α]pyrene in college students in China Bashu area
Authors: Ge Yutong , Yan Hailian , Shi Xiaodong , Wu Zhixiang , Wang Yueteng , Zhang Zelan , Luo Qing , Liu Wei , Liang Li , Peng Lianxin , Hu Jianping 
Published: August 2022

AbstractAs an extremely strong polycyclic aromatic hydrocarbon carcinogen, benzo[α]pyrene (BaP) is often produced during food processing at high temperatures. Recently, food safety, as well as toxicity mechanism and risk assessment of BaP, has received extensive attention. We first constructed the database of BaP pollution concentration in Chinese daily food with over 104 data items; collected dietary intake data using online survey; then assessed dietary exposure risk; and finally revealed the possible toxicity mechanism through four comparative molecular dynamics (MD) simulations. The statistical results showed that the concentration of BaP in olive oil was the highest, followed by that in fried meat products. The margins of exposure and incremental lifetime cancer risk both indicated that the dietary exposure to BaP of the participants was generally safe, but there were still some people with certain carcinogenic risks. Specifically, the health risk of the core district population was higher than that of the noncore district in Bashu area, and the female postgraduate group was higher than the male group with bachelor degree or below. From MD trajectories, BaP binding does not affect the global motion of individual nucleic acid sequences, but local weak noncovalent interactions changed greatly; it also weakens molecular interactions of nucleic acid with Bacillus stearothermophilus DNA polymerase I large fragment (BF), and significantly changes the cavity structure of recognition interface. This work not only reveals the possible toxicity mechanism of BaP, but also provides theoretical guidance for the subsequent optimization of food safety standards and reference of rational diet.
Effects of exogenous lipids on gelling properties of silver carp surimi gel subjected to microwave heating
Authors: Yang Yiling , Meng Linglu , Wang Yuxin , Yan Bowen 
Published: August 2022

AbstractLipids are important components of surimi products because they enhance the whiteness and flavor of food. The effects of three common types of exogenous lipids on the gel properties of surimi subjected to two different heating methods were investigated in this work, using frozen silver carp (Hypophthalmichthys molitrix) surimi as the raw material. The surimi gels were prepared by two‐stage water bath heating or single‐stage water bath heating followed by microwave heating. We found that the quality of surimi gels was in the order of lard > chicken fat/soybean oil, which may be associated with polyunsaturated fatty acid content. The surimi gel strength was reduced with an increase in the amount of lipid added. Microwave heating significantly increased the gel strength of surimi containing exogenous lipids when compared to conventional heating. Surimi gels prepared by microwave heating showed more denser protein network microstructures by scanning electron microscopy (SEM), suggesting aggregation of protein molecules. The findings of this study provide a theoretical basis for using microwave heating to generate surimi gels with exogenous lipids.
Organochlorine pesticides residue affinity in fish muscle and their public health risks in North West Ethiopia
Authors: Mitiku Birhan Agmas , Mitiku Marshet Adugna 
Published: August 2022

AbstractPesticides are the parent compounds, their metabolites, and associated impurities of agricultural and health chemical inputs. If they are found at concentration levels higher than the standard limits, they have potential negative impacts on the ecosystem in general and on fish and humans in particular. This study investigates organochlorine pesticides (OCPs) residue occurrences in fish muscle and assesses their public health potential risks, in North West Ethiopia. The concentration of OCPs residue under gas chromatography with electron capture detector (GC‐ECD) was detected in 37.84% of fish muscle samples. The mean amounts detected were Endosalfan I, 341.50 ± 32.19 μg/kg; Endosalfan II, 36.01 ± 2.3 μg/kg; Endosalfan sulfate, 5.43 ± 4.06 μg/kg; 4, 4, DDE (4,4‐dichlorodiphenyldichloroethylene), 64.01 ± 9.08 μg /kg; 4,4, DDD (4,4‐dichlorodiphenyldichloroethane), 5.65 ± 3.12 μg/kg; and 4, 4, DDT (4,4‐dichlorodiphenyltrichloroethane), 1.58 ± 0.30 μg/kg. The mean concentration of Endosalfan I tested in fish muscle samples was higher than that of the permissible limit of different international standards. However, due to the low per capita consumption rate of fish origin food in Ethiopia, the health risk index (HRI) ranges from 0.002 to 0.1275, which shows there is no public health risk. This study highlights the possibility of chemical residue occurrence in fish food products, and hence pesticide use regulations and monitoring concentration levels should be implemented regularly to avoid human and environmental health risks.
A High‐Energy Density Li‐Ion Hybrid Capacitor Fabricated from Bio‐Waste Derived Carbon Nanosheets Cathode and Graphite Anode
Authors: Nanaji Katchala , Pappu Samhita , Anandan Srinivasan , Rao Tata N. 
Published: August 2022

AbstractThe Li‐ion hybrid capacitor (LIHC) system explores the possibility of achieving both high energy and power density in a single energy storage system with an intercalation anode and capacitive cathode. However, to achieve a high power and energy‐based system, the properties of the cathode electrode material are vital. Here, bio‐waste plant stem‐derived activated porous carbon is explored as a cathode for LIHC application. A specific surface area of 1826 m2 g−1, enhanced degree of crystallinity, and graphitization results for porous carbon from activation by potassium hydroxide. When employed as supercapacitor material, the device exhibits good rate capability, energy, and power attributes with a specific capacitance of 116 F g−1 (1 A g−1). Simultaneously when tested for LIHC application the formulated device shows good capacity retention for 2500 cycles with a high energy density of 125 Wh kg−1 at a power density of 69 W kg−1. The work demonstrates unique, cost‐effective strategy to develop a crystalline high surface area carbon from any such bio‐waste sources to be employed as potential electrodes for energy storage applications.
Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen
Authors: Wang Jue , Deng Xin‐Ping , Hu Yun‐Song , Yue Juan , Ge Qiu , Li Xiao‐Long , Feng Zi‐Jian 
Published: August 2022

AbstractRepetitive transcranial magnetic stimulation (rTMS) has been used in the clinical treatment of Parkinson's disease (PD). Most of rTMS studies on PD used high‐frequency stimulation; however, excessive nonvoluntary movement may represent abnormally cortical excitability, which is likely to be suppressed by low‐frequency rTMS. Decreased neural activity in the basal ganglia on functional magnetic resonance imaging (fMRI) is a characteristic of PD. In the present study, we found that low‐frequency (1 Hz) rTMS targeting individual finger‐tapping activation elevated the amplitude of local neural activity (percentage amplitude fluctuation, PerAF) in the putamen as well as the functional connectivity (FC) of the stimulation target and basal ganglia in healthy participants. These results provide evidence for our hypothesis that low‐frequency rTMS over the individual task activation site can modulate deep brain functions, and that FC might serve as a bridge transmitting the impact of rTMS to the deep brain regions. It suggested that a precisely localized individual task activation site can act as a target for low‐frequency rTMS when it is used as a therapeutic tool for PD.
Does weight impact adolescent mental health? Evidence from China
Authors: Wang Si , Yang Qingqing 
Published: August 2022

AbstractIn this paper, we examine the causal impact of weight on adolescent mental health. Using the China Family Panel Studies, we find significant negative effects of adolescent weight, instrumented by cohort‐level parental body mass index (BMI), on mental illness. In particular, a one standard deviation increase in adolescent BMI z‐score decreases the K6 score by 0.766 (or 0.232 standard deviations). This finding is contrary to recent evidence from adults. We find this contrast can partly be explained by the different impacts of adolescent weight on self‐image and social relationships. Unlike adults, heavy adolescents feel that they are popular among peers in China.
A phase 1 study of ruxolitinib, steroids and lenalidomide for relapsed/refractory multiple myeloma patients
Authors: Berenson James R. , Kim Clara , Bujarski Sean , To Jennifer , Spektor Tanya M. , Martinez Daisy , Turner Carley , Ghermezi Matthew , Eades Benjamin M. , Swift Regina A. , Schwartz Gary , Eshaghian Shahrooz , Moss Robert A. , Lim Stephen , Vescio Robert 
Published: August 2022

AbstractRuxolitinib with lenalidomide and dexamethasone shows anti‐myeloma effects in vitro and in vivo. MUC1 leads to lenalidomide resistance in multiple myeloma (MM) cells, and ruxolitinib blocks its expression. Thus, ruxolitinib may restore sensitivity to lenalidomide. A phase I trial was conducted to determine the safety and efficacy of ruxolitinib with lenalidomide and methylprednisolone for patients with relapsed/refractory (RR)MM who had been treated with lenalidomide, steroids and a proteasome inhibitor and showed progressive disease at study entry. A traditional 3 + 3 dose escalation design was used to enroll subjects in four cohorts. Subjects received ruxolitinib twice daily, lenalidomide daily on days 1–21 of a 28 day cycle and methylprednisolone orally every other day. Primary endpoints were safety, clinical benefit rate (CBR) and overall response rate (ORR). Forty‐nine patients were enrolled. The median age was 64 years and they had received a median of six prior treatments including lenalidomide and steroids to which 94% were refractory. No dose limiting toxicities occurred. The CBR and ORR were 49% and 36%, respectively. All responding patients were refractory to lenalidomide. Grade 3 or 4 adverse events (AEs) included anemia (17%), decreased lymphocyte count (15%), and hypophosphatemia (10%). Most common serious AEs included sepsis (9.8%) and pneumonia (7.8%). This Phase I trial demonstrates that a JAK inhibitor, ruxolitinib, can overcome refractoriness to lenalidomide and steroids for patients with RRMM. These results represent a promising novel therapeutic approach for treating MM. NCT03110822.
Semen parameters after SARS‐CoV‐2 infection: A literature review
Authors: Tufvesson Kathrine , Catalini Laura , Fedder Jens 
Published: August 2022

AbstractBackground and AimsThe severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is known to affect multiple organs by binding to angiotensin‐converting enzyme 2 receptors and might therefore affect male fertility. This review aims to collect all original articles on the effects of SARS‐CoV‐2 infection on male fertility, including the duration of time after infection required for these effects to begin to manifest and recommend how clinicians should approach cases with a recent illness.MethodsThis review was developed according to the preferred reporting items for systematic reviews and meta‐analyses guidelines. The search string was applied to four online databases—namely Pubmed, Embase, Medline, and the Cochrane COVID‐19 Register—and screened using the online tool Covidence.org. Articles were eligible for inclusion if they were cohort studies involving a healthy male population diagnosed with COVID‐19, each of whom had semen samples collected before and after the infection or two different semen samples collected after the diagnosis.ResultsNine cohort studies were eventually included. Five articles had pre‐ and post‐COVID‐19 data while four had two sets of post‐COVID‐19 data. The three largest studies found a statistically significant decrease in all semen parameters when waiting less than 3 months from diagnosis before sample collection, and no significant differences in results when the ejaculate was analyzed more than 3 months after recovery. One study compared the COVID‐19 patients with a control group and found a significant decrease in semen parameters in the COVID‐19 group.ConclusionSpermatogenesis seems to be affected by SARS‐CoV‐2 infection, but the impact tends to reverse within 3–4 months. It is still unclear why male fertility is affected by SARS‐CoV‐2 infection, and it might be the result of several different components. Clinicians should consider recent SARS‐CoV‐2 infection as a possible reason for the low semen quality of patients' semen samples, and might therefore need to collect new samples after 4 months before further treatment.
Psychological consequences and the related factors among COVID‐19 survivors in southeastern Iran
Authors: Amiri Gooshki Esmat , Mangolian Shahrbabaki Parvin , Asadi Neda , Salmani Mahin 
Published: August 2022

AbstractIntroductionCoronavirus disease‐2019 (COVID‐19) is a new viral disease that has spread rapidly worldwide since December 2019 and there is no effective treatment for it. The current study aimed to investigate the psychological consequences and related factors among COVID‐19 survivors.MethodsThis descriptive analytical study was conducted on 152 patients with COVID‐19 referred to referral hospitals in southeastern Iran in 2020. Data collection tools were three questionnaires of demographic and background information, Depression Anxiety stress Scale (DASS‐21) and Impact of Events Scale‐Revised (IESR). Descriptive and inferential statistics and SPSS25 were used to analyze the data.ResultsThe mean age of patients was 39.52 ± 13.16 years. The patients were mostly female (63.8%). Seventy‐three percent of the patients had severe posttraumatic stress disorder, 26.3% had moderate depression and 26.3% had severe anxiety. The mean scores of posttraumatic stress, depression, and anxiety among patients with COVID‐19 were 41.59 ± 17.28, 12.13 ± 9.16, and 12.45 ± 10.71, respectively. Intensive care unit (ICU) admission, divorce, illiteracy, and retirement were all associated with higher psychological load among patients.Discussion and ConclusionThe results showed that patients with COVID‐19 had different levels of anxiety, depression, and posttraumatic stress. These results may direct the attention of the medical staff to the mental health of COVID‐19 patients, necessitating timely psychological care and intervention during an epidemic.
Assessing the validity of inertial measurement units for shoulder kinematics using a commercial sensor‐software system: A validation study
Authors: Henschke Jakob , Kaplick Hannes , Wochatz Monique , Engel Tilman 
Published: August 2022

AbstractBackground and AimsWearable inertial sensors may offer additional kinematic parameters of the shoulder compared to traditional instruments such as goniometers when elaborate and time‐consuming data processing procedures are undertaken. However, in clinical practice simple‐real time motion analysis is required to improve clinical reasoning. Therefore, the aim was to assess the criterion validity between a portable “off‐the‐shelf” sensor‐software system (IMU) and optical motion (Mocap) for measuring kinematic parameters during active shoulder movements.Methods24 healthy participants (9 female, 15 male, age 29 ± 4 years, height 177 ± 11 cm, weight 73 ± 14 kg) were included. Range of motion (ROM), total range of motion (TROM), peak and mean angular velocity of both systems were assessed during simple (abduction/adduction, horizontal flexion/horizontal extension, vertical flexion/extension, and external/internal rotation) and complex shoulder movements. Criterion validity was determined using intraclass‐correlation coefficients (ICC), root mean square error (RMSE) and Bland and Altmann analysis (bias; upper and lower limits of agreement).ResultsROM and TROM analysis revealed inconsistent validity during simple (ICC: 0.040−0.733, RMSE: 9.7°−20.3°, bias: 1.2°−50.7°) and insufficient agreement during complex shoulder movements (ICC: 0.104−0.453, RMSE: 10.1°−23.3°, bias: 1.0°−55.9°). Peak angular velocity (ICC: 0.202−0.865, RMSE: 14.6°/s−26.7°/s, bias: 10.2°/s−29.9°/s) and mean angular velocity (ICC: 0.019‐0.786, RMSE:6.1°/s−34.2°/s, bias: 1.6°/s−27.8°/s) were inconsistent.ConclusionsThe “off‐the‐shelf” sensor‐software system showed overall insufficient agreement with the gold standard. Further development of commercial IMU‐software‐solutions may increase measurement accuracy and permit their integration into everyday clinical practice.
Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection
Authors: Sharma Anusha , Gupta Sarika 
Published: August 2022

AbstractBackground and AimsFungal dermatophytosis or Tinea is a predominance in about 20%–25% of all total world populations. Dermatophyte infections are mainly caused by fungi belonging to Trichophyton, Epidermophyton, and Microsporum genera along with some other fungi. This epidemiological distribution may change with migration, lifestyle, immunosuppressive state, drug therapy, and socioeconomic conditions.MethodsThe present review indicated the bioefficacy of herbal and herbonanoconjugate as safe management of fungal dermatophytic infection.ResultsIt also emphasized the action mechanism as fungicidal and fungistatic with different harmful impacts indicating the need for alternative therapeutics. Simultaneously, the herbal and herbonanoconjugate approaches proved better to manage the prevalence of hepatotoxicity, nephrotoxicity, nausea, altered taste, anemia, GI upsets, hair loss, and so forth. due to conventional oral treatment approaches.ConclusionAdoption of the remedial approach can be recommended after preclinical trials' approval as a safe treatment.