bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO-026: University of Arizona partnership for Native American Cancer Prevention (NACP), outreach core
Authors: Leist Keyauni , Slowtalker Jacquanette 
Published: January 2022

Abstract
Cancer among American Indian/Alaska Native (AI/AN) communities is the second leading cause of death. The Partnership for Native American Cancer Prevention (NACP) was established to addresses cancer health disparities in Native Americans. The Outreach Core of NACP ensures research and tribal community engagement are undertaken in a respectful and inclusive manner with tribal communities. The University of Arizona (UA) Outreach Core: (1) developed (& distributed to 22 Arizona tribal communities) information materials focused on proper tribal consultation and engagement, foundational cancer information including statistics on leading causes of cancers, considerations for cancer survivors and caregivers over the continuum of cancer care including palliative/hospice care and clinical trials. (2) Hosts an Indigenous Cancer Prevention webinar series to showcase successful community-led cancer control initiatives in Indian Country. (3) In collaboration with the UA Responsible Conduct of Research (RCR) Program, offer training in Tribal Consultation & Engagement with Native Communities. (4) Partnered to develop a well-women video to promote preventative cancer screening of Native American women. As part of the Indigenous Cancer Prevention webinar series, a total of seven speakers have presented on various Native American-focused cancer initiatives including: understanding pediatric acute lymphoblastic leukemia, initiatives to address cancer burden; human papillomavirus and cervical cancer; quality of life among cancer survivors and survivorship issues; cancer among Alaska Natives; and cancer trends in Indian Country. Both the webinar series and the UA RCR training have been well received and pre- and post-tests and evaluations demonstrate an increase in knowledge and positive review of content and delivery. The webinar series has reached over 200 attendees of students, service providers, community members, and faculty across half of the United States.
Citation Format: Keyauni Leist, Jacquanette Slowtalker. University of Arizona partnership for Native American Cancer Prevention (NACP), outreach core [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-026.
Abstract PO-055: HPV knowledge, screening barriers and facilitators, and sources of health information among women living with HIV: Perspectives from the DC community
Authors: Ciceron Annie Coriolan , Jeon Min (Jaime) Jeong , Clausen Michelle Elise , Monroe Anne Kress , Magnus Manya , Le Daisy 
Published: January 2022

Abstract
Background: High-risk human papillomavirus (HPV) causes 99% of cervical cancer cases. Despite available prevention methods through the HPV vaccine and two screening modalities, women continue to die from cervical cancer worldwide. Cervical cancer is preventable, yet affects a great number of women living with HIV (WLH). Low screening rates among WLH further exasperates their already high risk of developing cervical cancer due to immunosuppression. Purpose: This study explores WLH's current cervical cancer knowledge, screening barriers and facilitators, and sources of health information. Methods: Focus group discussions were conducted with 39 WLH aged 21 years old or older, who resided in the Washington-Baltimore Metropolitan Area. Emergent themes were classified and organized into overarching domains and assembled with representative quotations. Results: The women had limited knowledge of HPV and the cervical cancer screening guidelines for WLH. Screening barriers also included decreased accessibility to cervical cancer screenings, a novel issue caused by the Coronavirus 2019 (COVID-19) pandemic. Screening facilitators included knowing someone diagnosed with cervical cancer and provider recommendations. WLH indicated that they obtained health information through in-person education (providers, peer groups) and written literature. Due to the pandemic, they also had to increasingly rely on remote and technology-based communication channels such as the internet, social media, television, radio, email, and SMS text messaging. Conclusions: Future health interventions need to explore the possibility of sharing messages and increasing cervical cancer and HPV knowledge of WLH through the use of SMS and other technology-based channels.
Citation Format: Annie Coriolan Ciceron, Min (Jaime) Jeong Jeon, Michelle Elise Clausen, Anne Kress Monroe, Manya Magnus, Daisy Le. HPV knowledge, screening barriers and facilitators, and sources of health information among women living with HIV: Perspectives from the DC community [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-055.
Abstract PO-058: Increasing liver cancer prevention knowledge through a community-based education initiative to improve liver cancer prevention for underserved African, Asian, and Hispanic communities
Authors: Lu Wenyue , Zhu Lin , Ibrahim Safa , Traub Kerry , Kim Ellen , Wong Ada , Rubio-Torio Nathaly , Gonzalez Evelyn , Fraser Marilyn A. , Yeh Ming-Chin , Ma Grace X. , Ogunwobi Olorunseun O. , Tan Yin 
Published: January 2022

Abstract
Background: Though a largely preventable disease, liver cancer is now the fastest-increasing cause of cancer death in the US, and it is highly fatal. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it disproportionally affect racial/ethnic minorities, especially the medically underserved. Most HCC cases are associated with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods: To increase awareness of liver cancer prevention and screening, we partnered with community-based organizations through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core, in the greater Philadelphia metropolitan and New York City to design and conduct a liver cancer prevention project. Pre- and post- survey data was collected from underserved Asian, African, and Hispanic American community members who participated in educational workshops. This abstract will report the 473 eligible participants' knowledge on HBV, HCV, and liver cancer both before and after the education. We conducted wilcoxon Signed-rank, Kruskal-Wallis, and Wilcoxon sum-rank tests. Results: Knowledge of risk factors increased significantly in all three communities from the pre-survey to the post-intervention survey (2.15 vs. 3.69, p&lt;0.0001). Knowledge of risk factors also significantly increased within the African (1.11, p&lt;0.0001), Asian (1.88, p&lt;0.0001) and Hispanic (3.21, p&lt;0.0001) American Communities. There were no significant differences in increased knowledge by gender (male= 2.18 vs female=2.25, p=0.72). Conclusions: The findings of our study show the importance and effectiveness educational interventions have on promoting liver cancer prevention knowledge among the minority groups who are most affected in the U.S. by liver cancer disparity.
Citation Format: Wenyue Lu, Lin Zhu, Safa Ibrahim, Kerry Traub, Ellen Kim, Ada Wong, Nathaly Rubio-Torio, Evelyn Gonzalez, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. Increasing liver cancer prevention knowledge through a community-based education initiative to improve liver cancer prevention for underserved African, Asian, and Hispanic communities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-058.
Abstract PO-070: Psychometric properties and analysis of the masculinity barriers to medical care scale among African American, Indigenous, and White men
Authors: Brooks Ellen , Figueroa Roger , Petersen Ethan , Campanelli Pamela , Kennedy Carson , Thorpe Roland J. , Levant Ronald F. , Rogers Charles R. 
Published: January 2022

Abstract
Background: The Masculinity Barriers to Medical Care (MBMC) scale was developed to assess masculinity barriers to medical care relative to colorectal cancer (CRC) screening uptake among non-Hispanic (NH) African-American/Black men. Objective: This study aimed to assess the psychometric properties of the MBMC Scale while applying it to different racial groups. Methods: Participants self-identifying as non-Hispanic (NH) Black, American Indian/Alaska Native (Indigenous), or NH White completed the web-based Masculinity Barriers to Medical Care, Psychosocial Factors, and CRC Screening Uptake & Intention Survey. We conducted exploratory factor analysis on a sample of 254 men and multivariate analysis of variance (MANOVA) on a separate sample of 637 men nationally representative by age and state of residence. Results: After assessment of psychometric properties, the MBMC scale was reduced from 24 to 18 items and from six to four subscales. Black men's mean scores were lowest on three of four subscales (Being Strong, Negative and Positive Attitudes) and highest on the Acknowledging Emotions subscale. Compared with both Indigenous and White men, Black men had significantly lower Negative Attitudes subscale scores and significantly higher scores on the Acknowledging Emotions subscale. Compared with both Indigenous and Black men, White men had significantly higher Being Strong and Positive Attitudes subscales scores. Conclusions: This study expands on previous research indicating that, among racialized populations of men, endorsement of traditional masculine ideologies influences engagement in preventive health behaviors. Our scale can be tailored to assess attitudes to screening for other cancers and diseases that disproportionately burden medically underserved populations.
Citation Format: Ellen Brooks, Roger Figueroa, Ethan Petersen, Pamela Campanelli, Carson Kennedy, Roland J. Thorpe, Jr., Ronald F. Levant, Charles R. Rogers. Psychometric properties and analysis of the masculinity barriers to medical care scale among African American, Indigenous, and White men [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-070.
Abstract PO-077: Access to care as a contributing factor to underlying disparities in Hispanic women with ovarian cancer in the United States
Authors: Schiavo Claudia B. , Armaiz Guillermo 
Published: January 2022

Abstract
In the United States, ovarian cancer accounts for only 3% of all cancers in U.S. women. Ovarian cancer trends in the United States report the highest incidence in non-Hispanic white women with Hispanic women having the second highest incidence. Ovarian cancer disparities are present within the Hispanic population because Hispanic women are more likely to be diagnosed with ovarian cancer, not only at an earlier age than non-Hispanic groups, but also at an earlier stage (I-II). Ovarian cancer has the highest mortality among gynecological malignancies in Hispanics, resulting from various factors including unequal access to screening and treatment disparities, such as adherence to treatment and volume-outcome paradigm. Outcomes are paradoxical among Hispanic women, because while a high proportion are diagnosed younger and at early stages, typically associated with improved survival outcomes, they are more likely to not receive the standard of care, which involves more than providing insurance, access, and the services patients need. Inequitable access to care can lead to noticeable differences in health, especially within the Hispanic community in the United States. Our objective is to define access within a conceptual framework of five dimensions—1) approachability; 2) acceptability; 3) availability and accommodation; 4) affordability; and 5) appropriateness—specifically in relation to ovarian cancer disparities in Hispanic women in the US. Utilizing these dimensions, we summarize available knowledge about how inequitable access to care contributes to the underlying disparities that Hispanic women in the US experience, focusing particularly on social determinants of health, as well as adherence to care and the volume-outcome relationship. The health care system needs to develop innovative strategies to educate and inform the surrounding Hispanic communities Despite the limited data available, we summarize the available literature and propose the application of different strategies to help address the potential—systemic, logistic, and geographic—barriers that affect how Hispanic women with ovarian cancer access health care, in order to implement a health care delivery system that is equitable.
Citation Format: Claudia B. Schiavo, Guillermo Armaiz. Access to care as a contributing factor to underlying disparities in Hispanic women with ovarian cancer in the United States [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-077.
Abstract PO-081: Cancer clinical trial access during the COVID-19 pandemic
Authors: Suresh Ashithkumar Beloor , Dahal Subecha , Gantz Christopher , Lopez AnaMaria 
Published: January 2022

Abstract
Introduction: Cancer clinical trial conduction during the COVID-19 pandemic required a rapid move to virtual engagement to support participant and research team safety. We were faced with the challenge of translating our approach from in-person to virtual engagement for recruitment, enrollment, and delivery of the study intervention. We present our strategies to conduct cancer clinical trials focused on cancer risk reduction during the COVID-19 pandemic. Subject Recruitment: Our multimodal approach utilized online platforms and established approaches like posters, flyers, and collaborating with community health workers to recruit participants. Our virtual engagement strategies include direct outreach to potential participants via email, the electronic medical record (EMR), and social media. Contact via email and the EMR was guided by study-defined eligibility criteria. Social media outreach was through institutional Twitter, Facebook, and video channel accounts. Twitter posts and chats were employed. Enrollment: e-consenting and remote consenting processes were instituted via REDCAP. Delivery of the Educational Risk Reduction Intervention: We also conducted the intervention using the Zoom platform and through a recorded video of the educational risk reduction intervention, which is shared with the participant via REDCAP. Challenges: As documented by others, the greatest challenge to virtual engagement is lack of internet access and lack of digital literacy. These factors have a greater impact on underserved populations, including the elderly, those with low socioeconomic status, those located farther from the cancer center, and racially/ethnically diverse populations. Conclusion: By translating study outreach and processes to virtual engagement, we were able to facilitate clinical trial access across diverse community subgroups and support subject participation in clinical trials during the COVID-19 pandemic.
Citation Format: Ashithkumar Beloor Suresh, Subecha Dahal, Christopher Gantz, AnaMaria Lopez. Cancer clinical trial access during the COVID-19 pandemic [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-081.
Abstract PO-101: CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women
Authors: Abou-Fadel Johnathan , Zhang Jun 
Published: January 2022

Abstract
Breast cancer is the most commonly diagnosed cancer worldwide and remains the second leading cause of cancer death. While breast cancer mortality has steadily declined over the past decades through medical advances, an alarming disparity in breast cancer mortality has emerged between African American women (AAW) and Caucasian American women (CAW); and new evidence suggests more aggressive behavior of triple-negative breast cancer (TNBC) in AAW may contribute to racial differences in tumor biology and mortality. Progesterone (PRG) is capable of exerting its cellular effects through either its classic, non-classic or combined responses through binding to either classic nuclear PRG receptors (nPRs) or non-classic membrane PRG receptors (mPRs), warranting both pathways an equally important status in PRG-mediated signaling. In our previous report, we demonstrated that the CCM signaling complex (CSC) consisting of CCM1, CCM2, and CCM3 proteins can couple both nPRs and mPRs signaling cascades to form a CSC-mPRs-PRG-nPRs (CmPn) signaling network in nPR positive(+) breast cancer cells. In this report, we furthered our research by establishing the CSC-mPRs-PRG (CmP) signaling network in nPR(-) breast cancer cells, demonstrating that a common core mechanism exists, regardless of nPR(+/-) cell type. This is the first report stating that inducible expression patterns exist between CCMs and major mPRs in TNBC cells. Furthermore, we firstly show mPRs in TNBC cells are localized in the nucleus and participate in nucleocytoplasmic shuttling in a coordinately synchronized fashion with CCM proteins under steroid actions, following the same cellular distribution as other well-defined steroid hormone receptors. Finally, for the first time, we deconvoluted the CmP signalosome by using multi-omics approaches, which helped us understand key factors within the CmP network, and identify 21 specific biomarkers with potential clinical applications associated with AAW-TNBC tumorigenesis. These novel biomarkers could have immediate clinical implications to dramatically improve health disparities among AAW-TNBCs.
Citation Format: Johnathan Abou-Fadel, Jun Zhang. CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-101.
Abstract PO-108: Predictors of retention rates in the Active Living After Cancer program at MD Anderson Cancer Center: A comparison of classes during and before COVID-19
Authors: Servino Kendahl , Mitchell Stacy , Lee Che Young , Liao Yue , Basen-Engquist Karen 
Published: January 2022

Background: As an overlooked aspect of cancer, survivorship often begs the question of “what's next?” once treatment is complete. Physical activity following treatment has been shown to improve quality of life and decrease rates of recurrence. The MD Anderson Active Living After Cancer Program (ALAC) has recruited over 900 cancer survivors and caregivers since its establishment in 2013. This study seeks to examine how retention rates have changed since the transition to virtual classes due to the COVID-19 pandemic, and whether variables associated with retention differ between in person and virtual classes. Methods: A retrospective study of baseline surveys completed by participants (N=860) through Redcap was conducted, excluding those currently enrolled in ongoing ALAC classes. A chi-square test was performed to determine whether completion rates were significantly different between in person and virtual classes. A bivariate regression model was used to determine whether participant demographics varied between virtual and in person classes, based on insurance status and education level. A logistic regression was performed to investigate whether these factors were predictors of retention in either class. Results: Retention rates significantly differed between virtual (87.91%) and in person classes (77.20%); participants of virtual classes were two times as likely to complete the program compared to their in-person counterparts (P=0.00). Compared to in person classes, uninsured participants comprised a larger proportion of virtual classes, while privately and publicly insured participants comprised a smaller proportion (P=0.014). In both classes, participants who never received a high school diploma or GED constituted the most common education level. Having insurance and completion of some higher education were only weakly associated with retention. Conclusion: Given the success of ALAC since its creation, we are interested in expanding enrollment beyond MD Anderson Cancer Center. This study provides understanding of the benefits and limitations of virtual classes since the rise of COVID-19. Overall, greater retention rates demonstrate the utility of virtual classes. Maintaining a virtual aspect of future ALAC classes, such as a hybrid program, may help improve survivor outreach by identifying potentially overlooked groups.
Citation Format: Kendahl Servino, Stacy Mitchell, Che Young Lee, Yue Liao, Karen Basen-Engquist. Predictors of retention rates in the Active Living After Cancer program at MD Anderson Cancer Center: A comparison of classes during and before COVID-19 [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-108.