bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical success factors‐based strategy to facilitate green manufacturing for responsible business: An application experience in Indian context
Authors: Seth Dinesh , Rehman Minhaj Ahemad A. 
Published: April 2022

AbstractFor responsible business, green manufacturing (GM) and its management demand an in‐depth examination of key areas which offer strategic advantage to the company while minimising environmental damage. It is significant in the context to a rapidly rising economy India, which is emerging as manufacturing hub for the globe and is also infamous for its greenhouse gas (GHG) emissions. This research offers a unique strategy to facilitate GM implementation by addressing critical success factors (CSFs), its intensity and its overall impact, through a framework in Indian context. Detailed literature review and industry experts' views are utilised to synthesise key CSFs in Indian context, followed by framework development for its application in a manufacturing company, through hybrid multicriteria decision‐making approach. This research highlights priorities and potential challenges that a manufacturing organisation will face if it wishes to implement GM. The findings strategically guide practitioners and researchers about where and what to focus and caution them before an organisation invests its resources. Research offers a powerful strategy to leverage and translate qualitative CSFs in the form of a quantitative intensity index. Authors expect that this CSFs‐based strategy will be beneficial to both researchers and professionals in strengthening the link between manufacturing and environment research domains.
Anatomy podcasts for medical education
Authors: Skadorwa Tymon 
Published: April 2022

AbstractThe implementation of podcasts as a complementary educational activity increased over the past year due to the Covid‐19 pandemic. Being an alternative channel for transmission of anatomical knowledge, the on‐demand audio broadcasts became an intriguing medium for both students and educators. This paper presents the results of a questionnaire study on the evaluation of an audio podcast designed specifically for the first‐year medical students as an innovative and optional component of the human anatomy course. The audience expressed their opinions in four categories: engagement in listening to the podcast, content and preferences, technical level and perspectives of using the podcast in further years of medical studies. Despite the non‐compulsory nature of the podcast, the listenership reached the level of 45%. In the study, 1608 listeners had access to the survey and the overall response rate was 35.9%. Based on the analysis, the attitude and preferences of the listeners were demonstrated, including the preferred time of listening, length of the episodes, selection of topics, format of the broadcast, or the method of its delivery. Students also commented on the influence of the podcast on passing the final exam in anatomy and a concept of recording broadcasts in a foreign language. The presented data allowed the recognition of the needs of medical students and contributed to the improvement of the ongoing project. The paper presents the technical data and guidelines for educators willing to include this medium in the students' anatomical curriculum.
In Silico Analysis Identifies the Anti‐Liver Injury Targets of Diammonium Glycyrrhizinate: Validated in Perfluorooctanoic Acid‐Lesioned Mouse Model
Authors: Qin Jingru , Song Jianhua , Liang Yujia , Jiao Aijun , Yang Bin 
Published: April 2022

AbstractLiver injury refers to a pathological condition that causes dysfunction to hepatic parenchymal cells. And diammonium glycyrrhizinate (DG) is clinically prescribed for hepatoprotection. To date, detailed information regarding DG against liver injury in molecular mechanisms remains unrevealed totally. In the present study, we applied network pharmacology and molecular docking to decipher substantial genes, biological functions of DG for treating liver injury. Furthermore, preclinical experiments using perfluorooctanoic acid (PFOA)‐induced liver injury in mice were used to validate the bioinformatic findings. Our results showed that the target network of DG and liver injury predominantly shared 90 genes. Eleven core genes of DG treating liver injury including ALB, TP53, TNF, CASP3, PTGS2, JUN, TLR4, IL10, STAT3, NOS3, FOS. The gene ontology and KEGG enrichment further highlighted their importance in regulation of cell proliferation, regulation of transcription, inflammatory response, regulation of NF‐kappaB import into nucleus, regulation of apoptotic process, T cell receptor signaling pathway, and Toll‐like receptor signaling pathway. Moreover, DG treatment was found to rescue the PFOA‐induced liver injury through the modulation of identified genes including TNF, CASP3, PTGS2, and ALB. Current integrated data from bioinformatics method and experimental validation uncovered that DG exerts potent actions to treat liver injury through regulating core targets associated with inflammation and immunomodulation.
The Isoflavanoid (+)‐PTC Regulates Cell‐Cycle Progression and Mitotic Spindle Assembly in a Prostate Cancer Cell Line
Authors: Moraes de Farias Kaio , Rosa‐Ribeiro Rafaela , Souza Edmarcia E. , Kobarg Jörg , Banwell Martin G. , de Brito Vieira Neto José , Leyenne Alves Sales Sarah , Roberto Ribeiro Costa Paulo , Cavalcante dos Santos Rafael , Vilaça Gaspar Francisco , Gomes Barreto Junior Amaro , da Conceição Ferreira Oliveira Maria , Odorico de Moraes Manoel , Libardi M. Furtado Cristiana , Carvalho Hernandes F. , Pessoa Claudia 
Published: April 2022

AbstractProstate cancer is the second most common malignancy in men and the development of effective therapeutic strategies remains challenging when more advanced, androgen‐independent or insensitive forms are involved. Accordingly, we have evaluated, using flow cytometry, confocal microscopy and image analysis, the anti‐proliferative effects of (+)‐2,3,9‐trimethoxypterocarpan [(+)‐PTC, 1] on relevant human prostate cancer cells as well as its capacity to control mitosis within them. In particular, the studies reported herein reveal that (+)‐PTC exerts anti‐proliferative activity against the PC‐3 cell lines by regulating cell‐cycle progression with mitosis being arrested in the prophase or prometaphase. Furthermore, it emerges that treatment of the target cells with this compound results in the formation of monopolar spindles, disorganized centrosomes and extensively disrupted γ‐tubulin distributions while centriole replication remains unaffected. Such effects suggest (+)‐PTC should be considered as a possible therapy for androgen‐insensitive/independent prostate cancer.
One‐Pot Solvothermal Synthesis of Carbon Black‐Supported CuO for Catalysis of CO2Electroreduction
Authors: Dias Eduardo H. , Da Silva Gelson T. S. T. , Da Cruz Jean C. , Ribeiro Caue 
Published: April 2022

AbstractHere we propose a simple one‐pot solvothermal method to synthesize well‐dispersed CuO catalysts over carbon black surface for application in CO2electrolysis. Although simple, the route produced catalysts with good performance even in lower CuO contents, increasing the efficiency of the catalytic layer. Films prepared by straightforward dropping on fluorine tin oxide (FTO) substrates were stable (up to 30 hours), showing good activity for CO2reduction reaction (CO2RR) and controlling the competitive H2evolution to preferentially form CO2reduction products (CO, formic acid, ethanol, and acetic acid). The results showed values of almost 50 % of faradaic efficiency for products of CO2reduction, comparable with other more elaborated catalysts reported in the literature, even utilizing cheap support, easy synthesis, and lower potentials.
On‐Surface Metathesis of an Ionic Liquid on Ag(111)
Authors: Massicot Stephen , Sasaki Tomoya , Lexow Matthias , Maier Florian , Kuwabata Susumu , Steinrück Hans‐Peter 
Published: April 2022

AbstractWe investigated the adsorption, surface enrichment, ion exchange, and on‐surface metathesis of ultrathin mixed IL films on Ag(111). We stepwise deposited 0.5 ML of the protic IL diethylmethylammonium trifluoromethanesulfonate ([dema][TfO]) and 1.0 ML of the aprotic IL 1‐methyl‐3‐octylimidazolium hexafluorophosphate ([C8C1Im][PF6]) at around 90 K. Thereafter, the resulting layered frozen film was heated to 550 K, and the thermally induced phenomena were monitored in situ by angle‐resolved X‐ray photoelectron spectroscopy. Between 135 and 200 K, [TfO]− anions at the Ag(111) surface are exchanged by [PF6]− anions and enriched together with [C8C1Im]+ cations at the IL/vacuum interface. Upon further heating, [dema][PF6] and [OMIm][PF6] desorb selectively at ∼235 and ∼380 K, respectively. Hereby, a wetting layer of pure [C8C1Im][TfO] is formed by on‐surface metathesis at the IL/metal interface, which completely desorbs at ∼480 K. For comparison, ion enrichment at the vacuum/IL interface was also studied in macroscopic IL mixtures, where no influence of the solid support is expected.
Direct Reduction of Siderite Ore Combined with Catalytic CO/CO2 Hydrogenation to Methane and Methanol: A Technology Concept
Authors: Kleiber Sascha , Loder Astrid , Siebenhofer Matthäus , Böhm Andreas , Lux Susanne 
Published: April 2022

AbstractIndustrial CO2 emission mitigation necessitates holistic technology concepts; especially in high‐emission industrial sectors like the iron and steel industry. A novel direct reduction technology with hydrogen reduces CO2 emissions in iron production from siderite ore by more than 60 %. Subsequent valorization of the process gas, consisting of unconverted hydrogen, carbon monoxide, and CO2, by catalytic hydrogenation to methane and methanol completes the technology concept. This route gives access to CO2 emission‐lean iron production from siderite ore, fossil‐free methane and methanol synthesis, and thus, improved energy density of the energy carrier hydrogen.
A comparison of local therapy alone with local plus systemic therapy for stage I pT1aN0M0 HER2+ breast cancer: A National Cancer Database analysis
Authors: Cao Lifen , Towe Christopher W. , Shenk Robert , Stabellini Nickolas , Amin Amanda L. , Montero Alberto J. 
Published: April 2022

BackgroundSmall invasive breast cancers (BCs) with tumor sizes ≤5 mm (T1a) are associated with an excellent prognosis without systemic therapy. Although HER2 overexpression (HER2+) is associated with a higher risk of recurrence and poorer clinical outcomes, in the absence of HER2 directed therapy, it remains unclear whether adjuvant systemic therapy is necessary in node‐negative patients diagnosed with HER2+ invasive BCs ≤5 mm (pT1aN0M0).MethodsThe National Cancer Database was searched to identify patients diagnosed with HER2+ pT1aN0M0 BCs from 2004 to 2017. The cohort was stratified by treatment status: local therapy alone or local plus adjuvant systemic therapy. A 1:1 propensity match was performed. Overall survival (OS) was analyzed using stratified multivariable Cox proportional hazards regression analyses.ResultsOf the 8948 patients found, 4026 (45.0%) underwent surgery alone, and 4922 (55.0%) received surgery plus systemic therapy. Patients with either moderately differentiated (odds ratio [OR], 2.053; P < .001) or poorly/undifferentiated tumors (OR, 3.780; P < .001) or with the presence of lymphovascular invasion (OR, 3.351; P < .001) were more likely to have received systemic therapy. Propensity matching generated 1162 pairs of patients who were hormone receptor positive (HR+) and 748 pairs who were hormone receptor negative (HR–). Propensity matching effectively reduced selection bias between study groups. In the matched cohort, the addition of systemic therapy was not associated with superior OS (hazard ratio for HR+, 1.613; P = .107, and hazard ratio for HR– 1.319; P = .369) compared with patients who received local therapy alone.ConclusionsIn pT1aN0M0 HER2+ BC, the addition of adjuvant systemic therapy after surgical excision was not associated with improved OS compared with local therapy alone.
A deep learning method for automatic SMS spam classification: Performance of learning algorithms on indigenous dataset
Authors: Abayomi‐Alli Olusola , Misra Sanjay , Abayomi‐Alli Adebayo 
Published: April 2022

AbstractSMS, one of the most popular and fast‐growing GSM value‐added services worldwide, has attracted unwanted SMS, also known as SMS spam. The effects of SMS spam are significant as it affects both the users and the service providers, causing a massive gap in trust among both parties. This article presents a deep learning model based on BiLSTM. Further, it compares our results with some of the states of the art machine learning (ML) algorithm on two datasets: our newly collected dataset and the popular UCI SMS dataset. This study aims to evaluate the performance of diverse learning models and compare the result of the new dataset expanded (ExAIS_SMS) using the following metrics the true positive (TP), false positive (FP), F‐measure, recall, precision, and overall accuracy. The average accuracy for the BiLSTSM model achieved moderately improved results compared to some of the ML classifiers. The experimental results achieved significant improvement from the ground truth results after effective fine‐tuning of some of the parameters. The BiLSTM model using the ExAIS_SMS dataset attained an accuracy of 93.4% and 98.6% for UCI datasets. Further comparison of the two datasets on the state‐of‐the‐art ML classifiers gave an accuracy of Naive Bayes, BayesNet, SOM, decision tree, C4.5, J48 is 89.64%, 91.11%, 88.24%, 75.76%, 80.24%, and 79.2% respectively for ExAIS_SMS datasets. In conclusion, our proposed BiLSTM model showed significant improvement over traditional ML classifiers. To further validate the robustness of our model, we applied the UCI datasets, and our results showed optimal performance while classifying SMS spam messages based on some metrics: accuracy, precision, recall, and F‐measure.
Role of environmental and occupational factors in fall‐related maxillofacial fractures
Authors: Sattar Nigam , Rabia Rahat Gillani Syeda , Erkin Mahwish , Khan Muslim , Abbas Maryam , Khurshid khattak Nimrah 
Published: April 2022

AbstractObjectivesThe objective of this study was to determine the frequency and patterns of maxillofacial fractures in falls due to environmental and occupational reasons.Material and MethodsOne hundred and nineteen patients were included in this study who presented to the department of Oral and maxillofacial surgery at Khyber College of Dentistry, Peshawar. The duration of study was 3 years from January 1, 2017 to December 31, 2019. Demographic data such as age, gender and data environmental or occupational etiology of falls and pattern of fractures was noted in a customized Performa after detailed history, clinical and radiographic examination. Patients of maxillofacial fractures resulting due to falls with age ranging from 16 to 64 years were included. Those cases of falls that presented with systemic diseases or had chances of pathological fractures were excluded from the study.ResultsMale population was affected more than females (60% vs. 39.4%). The mean age was 32.39 SD ± 16.031. Falls due to environmental factors were more common than occupational factors (81.5% vs 18.5%). Fracture of midface was more common (57.1%) than fracture of mandible (36.7%) in patients of falls. 5.5% had both midface and mandible fractures.ConclusionWe concluded that Environmental and work‐related facial fractures in falls are common in third and fourth decade of life. Falls due to stumbling, tripping and slipping, falls from height and falls from stairs most commonly result in midface fractures. Mandible fractures are commonly seen in sportsmen and laborers. Preventive strategies shall be adopted to prevent morbidity and mortality associated with such injuries.
A critical review of cannabis in medicine and dentistry: A look back and the path forward
Authors: Abidi Ammaar H. , Alghamdi Sahar S. , Derefinko Karen 
Published: April 2022

AbstractIntroductionIn the last two decades, our understanding of the therapeutic utility and medicinal properties of cannabis has greatly changed. This change has been accompanied by widespread cannabis use in various communities and different age groups, especially within the United States. With this increase, we should consider the potential effects of cannabis–hemp on general public health and how they could alter therapeutic outcomes.Material and MethodsThe present investigation examined cannabis use for recreational and therapeutic use and a review of pertinent indexed literature was performed. The focused question evaluates “how cannabis or hemp products impact health parameters and do they provide potential therapeutic value in dentistry, and how do they interact with conventional medicines (drugs).” Indexed databases (PubMed/Medline, EMBASE) were searched without any time restrictions but language was restricted to English.ResultsThe review highlights dental concerns of cannabis usage, the need to understand the endocannabinoid system (ECS), cannabinoid receptor system, its endogenous ligands, pharmacology, metabolism, current oral health, and medical dilemma to ascertain the detrimental or beneficial effects of using cannabis–hemp products. The pharmacological effects of pure cannabidiol (CBD) have been studied extensively while cannabis extracts can vary significantly and lack empirical studies. Several metabolic pathways are affected by cannabis use and could pose a potential drug interaction. The chronic use of cannabis is associated with health issues, but the therapeutic potential is multifold since there is a regulatory role of ECS in many pathologies.ConclusionCurrent shortcomings in understanding the benefits of cannabis or hemp products are limited due to pharmacological and clinical effects not being predictable, while marketed products vary greatly in phytocompounds warrant further empirical investigation. Given the healthcare challenges to manage acute and chronic pain, this review highlights both cannabis and CBD‐hemp extracts to help identify the therapeutic application for patient populations suffering from anxiety, inflammation, and dental pain.
Digital planning of composite customized veneers using Digital Smile Design: Evaluation of its accuracy and manufacturing
Authors: Ortensi Luca , Sigari Giancarlo , La Rosa Giusy Rita Maria , Ferri Agnese , Grande Francesco , Pedullà Eugenio 
Published: April 2022

AbstractObjectivesThis study aimed to evaluate the production of customized composite veneers starting from a two‐dimensional (2D) digital preview using the Digital Smile System (DSS).Material and MethodsA photographic examination of 30 patients was performed by taking two digital pictures of the face and a digital preview through the DSS. Moreover, optical scans of the dental arches were obtained and the data were entered into a three‐dimensional (3D) software to prepare a virtual preview. The standard tessellation language files were sent for production using CAD‐CAM technology. The Friedman test, Bonferroni, and Dunn post hoc tests were used, comparing the linear measurements of the 2D and 3D plans and the final veneers (α = .05).ResultsSignificant differences emerged between the pictures and digital scans on the mesial–distal widths of the lateral incisors and canine. Linear measurements in the 2D plan were significantly different from those of the 3D plan, except for the height measures of incisors. No significant changes were found on comparing the parameters of the 2D and 3D plans with those of the final pieces.ConclusionsThe customized veneers were clinically adequate and similar to 2D and 3D plans, although significant differences emerged between the picture and digital scans as well as between the 2D and 3D plans.
Cultural dynamics and conflict management: Evidence from Buipe and Bole chieftaincy conflicts in the Savannah Region, Ghana
Authors: Ibrahim Mohammed Gadafi , Mahama Edward Salifu , Fuseini Moses Naiim 
Published: April 2022

AbstractChieftaincy violence and tensions have persisted in most of the Savannah Region's traditional areas, and attempts to resolve them through the formal court system have failed since the parties reject most court decisions. Consequently, this study examined cultural dynamics in conflict management. A multiple case study design was used while data were gathered using interviews and focus group discussions. Thematic and cross‐case analyses were used to analyze the data. The study found that structural causes of the conflicts are interwoven with cultural breakdowns. The cognizance of culture into the management process by the traditional committees formed resulted in acceptable outcomes, as the processes proved to be meaningful to all stakeholders because it better met local needs. It is proposed that stakeholders in conflict management and peacebuilding should encourage, develop, and expedite local conflict management processes, with culture as an essential factor to consider in the process.
From microbes to mammals: Pond biodiversity homogenization across different land‐use types in an agricultural landscape
Authors: Ionescu D. , Bizic M. , Karnatak R. , Musseau C. L. , Onandia G. , Kasada M. , Berger S. A. , Nejstgaard J. C. , Ryo M. , Lischeid G. , Gessner M. O. , Wollrab S. , Grossart H.‐P. 
Published: April 2022

AbstractLocal biodiversity patterns are expected to strongly reflect variation in topography, land use, dispersal boundaries, nutrient supplies, contaminant spread, management practices, and other anthropogenic influences. Contrary to this expectation, studies focusing on specific taxa revealed a biodiversity homogenization effect in areas subjected to long‐term intensive industrial agriculture. We investigated whether land use affects biodiversity levels and community composition (α‐ and β‐diversity) in 67 kettle holes (KH) representing small aquatic islands embedded in the patchwork matrix of a largely agricultural landscape comprising grassland, forest, and arable fields. These KH, similar to millions of standing water bodies of glacial origin, spread across northern Europe, Asia, and North America, are physico‐chemically diverse and differ in the degree of coupling with their surroundings. We assessed aquatic and sediment biodiversity patterns of eukaryotes, Bacteria, and Archaea in relation to environmental features of the KH, using deep‐amplicon‐sequencing of environmental DNA (eDNA). First, we asked whether deep sequencing of eDNA provides a representative picture of KH aquatic biodiversity across the Bacteria, Archaea, and eukaryotes. Second, we investigated if and to what extent KH biodiversity is influenced by the surrounding land use. We hypothesized that richness and community composition will greatly differ in KH from agricultural land use compared with KH in grasslands and forests. Our data show that deep eDNA amplicon sequencing is useful for in‐depth assessments of cross‐domain biodiversity comprising both micro‐ and macro‐organisms, but has limitations with respect to single‐taxa conservation studies. Using this broad method, we show that sediment eDNA, integrating several years to decades, depicts the history of agricultural land‐use intensification. Aquatic biodiversity was best explained by seasonality, whereas land‐use type explained little of the variation. We concluded that, counter to our hypothesis, land use intensification coupled with landscape wide nutrient enrichment (including atmospheric deposition), groundwater connectivity between KH and organismal (active and passive) dispersal in the tight network of ponds, resulted in a biodiversity homogenization in the KH water, leveling off today's detectable differences in KH biodiversity between land‐use types. These findings have profound implications for measures and management strategies to combat current biodiversity loss in agricultural landscapes worldwide.