bluuebunny/crossref_metadata_2025_split huggingface dataset:
Button Mushroom - Potential Source of Vitamin D2 and Possibilities of
Value Addition
Authors: Singh Simran , Joshi Ila 
Published: June 2022

Background:
Despite, being known as the sunshine vitamin, there is a widespread deficiency
of vitamin D. Mushrooms upon exposure to sunlight or UV radiations can synthesize
vitamin D2 due to the presence of its precursor, ergosterol. The most common mushroom to be
consumed worldwide is the button mushroom (Agaricus bisporus). These mushrooms possess a
high nutritional value and have many therapeutic benefits.

Objectives:
This review aims to comprehend the potential of button mushrooms as a source of
vitamin D2 and the possibilities of making value added products by incorporating button mushrooms.

Conclusion:
As button mushrooms are grown in dark chambers, they have negligible amounts of
vitamin D2, however, on exposure to sunlight or UV B radiation, nutritionally significant vitamin
D2 can be generated in fresh, whole, sliced or dried powder. The synthesis of vitamin D2 is
largely dependent on the type of UV radiation, its intensity, temperature and exposed surface area.
As fresh button mushrooms are highly perishable, they are often preserved in the form of
jams, sauce, pickles and candy. Dried button mushroom powder finds utility in formulating nutrient
enriched cakes, breads, biscuits, cookies, soup powders and composite flours. With the ever-
increasing demand for novel health foods, vitamin D enhanced button mushroom and its powder
can be used in various forms in the diet as a sustainable non-animal substitute to supplements
and pills to tackle vitamin D deficiency.
A Concise Review of Common Plant-derived Compounds as a Potential
Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into
Structure-Activity-Relationship
Authors: Nishal Suchitra , Phaugat Parmita , Bazaad Jyoti , Dhaka Rubal , Khatkar Sarita , Khatkar Anurag , Khayatkashani Maryam , Alizadeh Pooyan , Haghighi Shima Motavalli , Mehri Mohammad , Kashani Hamid Reza Khayat 
Published: June 2022

Abstract:
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurological
illnesses that affect people in their later years. Memory loss is the hallmark of Alzheimer’s disease,
while dyskinesia, or loss of mobility, is associated with muscle rigidity and tremors in PD. Both
diseases are unrelated, however, they do have a few similarities associated with extrapyramidal abnormalities,
particularly stiffness, which has been linked to concomitant PD in many AD patients. Increased
levels of IL-1, IL-6, and TNF in the AD and PD patients can be regarded as evidence of systemic
inflammation associated with each of these neurodegenerative disorders. One of the primary
variables in the progression of neurodegenerative disorders is oxidative stress. Many medicinal plants
and their secondary metabolites have been claimed to be able to help people with neurodegenerative
disorders like AD and PD. Anti-inflammatory, antioxidant, antiapoptotic, monoamine oxidase inhibition,
acetylcholinesterase, and neurotrophic pursuits are among the major mechanisms identified by
which phytochemicals exert their neuroprotective effects and potential maintenance of neurological
health in old age. In regard to neurodegenerative disorders, numerable plant-based drugs like alkaloids,
iridoids, terpenes, and flavones are employed for the treatment. Structure-activity relationships
(SAR) and quantitative structure-activity relationships (QSAR) are used to investigate the link between
bioactivity and the chemical configuration of substances. The SAR and QSAR of natural plant
components employed in AD and PD are discussed in the current review.
Intriguing Role of Gut-Brain Axis on Cognition with an Emphasis on
Interaction with Papez Circuit
Authors: Xavier Joyal , Anu M. , Fathima A.S. , Ravichandiran V. , Kumar Nitesh 
Published: June 2022

Abstract:
The gut microbiome is a complicated ecosystem of around a hundred billion symbiotic bacteria
cells. Bidirectional communication between the gut and the brain is facilitated by the immune
system, the enteric nervous system, the vagus nerve, and microbial compounds such as tryptophan metabolites
and short-chain fatty acids (SCFAs). The current study emphasises the relationship of the
gut-brain axis with cognitive performance and elucidates the underlying biological components, with a
focus on neurotransmitters such as serotonin, indole derivatives, and catecholamine. These biological
components play important roles in both the digestive and brain systems. Recent research has linked
the gut microbiome to a variety of cognitive disorders, including Alzheimer's (AD). The review describes
the intriguing role of the gut-brain axis in recognition memory depending on local network
connections within the hippocampal as well as other additional hippocampal portions of the Papez circuit.
The available data from various research papers show how the gut microbiota might alter brain
function and hence psychotic and cognitive illnesses. The role of supplementary probiotics is emphasized
for the reduction of brain-related dysfunction as a viable strategy in handling cognitive disorders.
Further, the study elucidates the mode of action of probiotics with reported adverse effects.
Herbal Therapeutics as Potential Prophylaxis for SARS-CoV-2 Infection
Authors: Singhal Shipra , Kumar Abhishek , Katiyar Deepti , Patil Vaishali M. 
Published: June 2022

Introduction:
The global pandemic COVID-19 and its uncontrolled spread and lack of effective therapeutics demand to investigate the herbal resources in search of novel, safe and potent therapeutics. Herbal medicines have proven the advantage of multi-target potential and thus can be investigated for virus-host interaction protein and viral protein targets.

Objectives:
Manuscript aims to provide an outcome-based analysis of studies performed towards evaluation of herbal compounds as anti-COVID agents. The studies focus on the proposed mechanism of viral inhibition by herbal compounds.

Methods:
The details on modern drug discovery approaches for investigation of potential antiviral agents includes in silico screening, ADMET and molecular docking studies. It helps to establish the probable mechanism of viral inhibition as well as to establish pharmacophore. The reports explaining role of herbal therapeutics/phytochemicals in antiviral drug development have been thoroughly searched.

Results:
The study summarizes herbal therapeutics and phytochemicals based on their antiviral properties against various pathogenic viruses. Herbal compounds that have an interesting role in the development of therapeutics and herd immunity against SARS-CoV-2 are included and discussed.

Conclusion:
The manuscript provides a summarized description of herbal resources and phytochemicals which are under investigation or have been investigated as potential therapeutic option for SARS-COV-2 inhibition. It will be a useful resource for researchers interested in the development of herbal therapeutics for the prevention and/or treatment of COVID-19.
FACTORS ASSOCIATED WITH SEVERE HYPERCALCEMIA IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM
Authors: Yazidi Meriem , Essayeh Sawsen , Oueslati Ibtissem , Khessairi Nadia , Chaker Fatma , Chihaoui Melika 
Published: June 2022

Objectives: To determine the factors associated with severe hypercalcemia (SH) in primary hyperparathyroidism (PHPT).
Methods: This is a retrospective study involving the medical records of 123 patients with PHPT collected over a period of 20 years. The patients were subdivided into two groups according to their highest calcium level: ≥ 3.25 mmol/l (SH) or < 3.25 mmol/l (Moderate hypercalcemia). The two groups were compared by univariate and multivariate analysis according to their socio-demographic, clinical and paraclinical parameters.
Results: The prevalence of SH was 35.8%. Clinical factors associated with SH were abdominal pain (p=0.02), vomiting (p=0.05), and acute pancreatitis (p=0.005). Biological factors associated with SH were higher PTH level (p=0.001) and vitamin D deficiency (p=0.01). The parathyroid adenoma size was significantly higher and parathyroid carcinoma was more frequent in the SH group (p=0.001 and p=0.06, respectively). After multivariate analysis, the factors independently associated with SH were a parathyroid adenoma size ≥20 mm and a PTH level ≥300 pg /ml (adjusted odds ratios = 12 and 7.7 respectively).
Conclusion: In patients with PHPT, a PTH level ≥300 pg/ml and a parathyroid adenoma size ≥20 mm are the main predictors of the onset of SH. Acute pancreatitis and parathyroid carcinoma appear to be more common in these forms of PHPT, requiring prompt surgical management after medical preparation.
Programmatic Adoption and Implementation of Video-Observed Therapy in Minnesota: Prospective Observational Cohort Study
Authors: Bachina Preetham , Lippincott Christopher Kirk , Perry Allison , Munk Elizabeth , Maltas Gina , Bohr Rebecca , Rock Robert Bryan , Shah Maunank 
Published: June 2022

Background
In-person directly observed therapy (DOT) is standard of care for tuberculosis (TB) treatment adherence monitoring in the US, with increasing use of video-DOT (vDOT). In Minneapolis, vDOT became available in 2019.

Objective
In this paper, we aimed to evaluate the use and effectiveness of vDOT in a program setting, including comparison of verified adherence among those receiving vDOT and in-person DOT. We also sought to understand the impact of COVID-19 on TB treatment adherence and technology adoption.

Methods
We abstracted routinely collected data on individuals receiving therapy for TB in Minneapolis, MN, between September 2019 and June 2021. Our primary outcomes were to assess vDOT use and treatment adherence, defined as the proportion of prescribed doses (7 days per week) verified by observation (in person versus video-DOT), and to compare individuals receiving therapy in the pre–COVID-19 (before March 2020), and post–COVID-19 (after March 2020) periods; within the post–COVID-19 period, we evaluated early COVID-19 (March-August 2020), and intra–COVID-19 (after August 2020) periods.

Results
Among 49 patients with TB (mean age 41, SD 19; n=27, 55% female and n=47, 96% non–US born), 18 (36.7%) received treatment during the post–COVID-19 period. Overall, verified adherence (proportion of observed doses) was significantly higher when using vDOT (mean 81%, SD 17.4) compared to in-person DOT (mean 54.5%, SD 10.9; P=.001). The adoption of vDOT increased significantly from 35% (11/31) of patients with TB in the pre–COVID-19 period to 67% (12/18) in the post–COVID-19 period (P=.04). Consequently, overall verified (ie, observed) adherence among all patients with TB in the clinic improved across the study periods (56%, 67%, and 79%, P=.001 for the pre–, early, and intra–COVID-19 periods, respectively).

Conclusions
vDOT use increased after the COVID-19 period, was more effective than in-person DOT at verifying ingestion of prescribed treatment, and led to overall increased verified adherence in the clinic despite the onset of the COVID-19 pandemic.
Factors Associated with Mental Distress Among Medical Students of Universitas Pembangunan Nasional Veteran Jakarta
Authors: Arvant Anisya Zakiyyahaya , Wahyuningsih Sri , Dewi Suzy Yusna 
Published: June 2022

Background: Mental distress refers to common mental disorders, such as depression, anxiety, and somatic symptoms, and is considered public health problem. It is reported that university students tend to have higher levels of mental distress compared to the general population, especially in medical students.Objective: The purpose of this study is to determine the risk factors affecting mental distress among medical students.Methods: A cross-sectional study using a survey was conducted among preclinical medical students at UPN Veteran Jakarta in June 2020. This study used proportional stratified sampling to complete questionnaires including demographic characteristics, adverse childhood experiences (ACE), family APGAR, and self-reporting questionnaire (SRQ-20). Data were analyzed by using logistic regression.Results: Among 138 participants, 36.2% had at least one of ACE, 55.1% of students came from a family with dysfunction, and 36.2% experienced mental distress. In multivariate analyses, some essential factors associated with mental distress are gender (OR=12.059, 95% CI: 2.311,62.916), adverse childhood experiences (OR=3.080, 95% CI: 1.903,4.983), family function (OR=2.733, 95% CI:1.097,6.809), and family structure (OR=0.290, 95% CI: 0.085,0.984).Conclusion: Students who are female, have history of adverse childhood experience, come from family with dysfunction, or non- nuclear family structure are more likely to be screened positive for mental distress. This study recommends an urgency of counselling service availability for medical students and community awareness to build a healthy family environment.
Case Report: Type 2 Diabetes Mellitus for The Elderly with Less Family Support
Authors: Saftarina Fitria 
Published: June 2022

Mrs. R, 65 years old came to Puskesmas B with complaints of fatigue during activities accompanied by weakness since 1 week ago. The patient has been diagnosed with Diabetes Mellitus since 2 years ago, but the patient admitted that she sometimes went to the health center once every 2 or 3 months depending on her complaints. According to the patient's acknowledgment, initially complaints of fatigue were felt rarely but gradually became more frequent and appeared during light activities and felt continuously. Complaints are not accompanied by blurred vision or numbness.The patient admitted that if the medicine from the Puskesmas ran out, complaints in the form of frequent thirst, frequent urination, hunger, and fatigue were felt again which indicated that the patient's blood sugar was rising, and the patient admitted that the highest blood sugar reached 600 mg/dL. During Mrs. R's treatment, she not only went to the health center for treatment but also frequently went to midwives and paramedics near the house.Mrs. R took the drugs metformin and glimepiride if she had just gone to a health professional when she had a complaint. Additionally, Mrs. R admitted that because of the complaint of feeling weak, Mrs. R often consumed date juice 3 X 1 spoon every day. Mrs. R is often given explanations by health workers to maintain her diet, but according to her she still cannot regulate her diet properly. Mrs. R still can be active and currently the patient is active as a housewife. Every Saturday, Mrs. R follows the exercise program from the village, namely elderly gymnastics, while on other days Mrs. R does not do sports, and only does home activities. Mrs. R denied smoking history, denied drinking alcohol, and denied taking drugs. Mrs. R currently lives with her husband and one grandson.
Desafíos de dos instituciones de educación superior de la Amazonia en el enfrentamiento de la pandemia de COVID-19
Authors: Leite Carlinda , Lopes de Sousa Walter 
Published: June 2022

El artículo presenta situaciones de las dos universidades públicas de una ciudad del interior de la Amazonia brasileña en el enfrentamiento de la pandemia de SARS-CoV-2 (Covid-19) y los efectos que tuvo en el funcionamiento de esas instituciones de educación superior. Desde el punto de vista metodológico, el estudio recurrió a la legislación brasileña publicada en el período de la pandemia y a las entrevistas de rectores y coordinadores de esas universidades. Estos discursos, interpretados por análisis de contenido, permitieron identificar cómo cada institución encontró su manera de lidiar con las adversidades, frente a las realidades que las caracterizan. Fue posible también reconocer la importancia de planos alternativos para mediano y largo plazo, como los definidos en el ámbito de la Unión Europea, que proponen alfabetizar digitalmente las personas para que el uso de las tecnologías digitales pase a ser parte de la vida personal y educacional de cada uno y que no sean solamente utilizadas como paliativo de emergencia, como ocurre en Brasil, tal como pasó cuando fueron necesarios en esa pandemia.
Penerapan Project Base Learning Dalam Meningkatkan Keterampilan Berpikir Kreatif dan Hasil Belajar Untuk Mata Kuliah Pengendalian Vektor dan Binatang Penganggu
Authors: Putri Fitria Eka , Hidayati Fajrina , Lesmana S Oka , Hubaybah Hubaybah , Fitri Adelina 
Published: June 2022

One of the problems found during the learning process is the use of learning methods that do not vary can cause students to feel bored and bored, so that the learning process is less effective and learning objectives are not achieved as expected. Based on this fact, it is also necessary to select appropriate and effective learning models to be able to develop students' creative thinking skills. One of the learning models that can help students obtain information, ideas, skills, ways of thinking, and express their own ideas is by using the Project Based Learning (PjBL) model. This type of research is a qualitative classroom action research (classroom action research). This research was conducted on the fifth semester students of environmental health who took the subject of vector and nuisance control, totaling 36 people. The results showed that students' thinking skills were in the creative category on each indicator of fluency 71.86%, flexibility 68.1%, detailing 76.34% and authenticity 77.78% and student learning outcomes increased on individual and group project assignments to 78.5 % of these learning outcomes have exceeded the target of 75%.

Key words: PjBL, Improving Creative Thinking Skills And Learning Outcomes

Abstrak

Salah satu permasalahan yang ditemukan pada saat proses pembelajaran adalah Penggunaan metode pembelajaran yang tidak bervariasi dapat mengakibatkan mahasiswa merasa jenuh dan bosan, sehingga proses pembelajaran kurang efektif dan tujuan pembelajaran tidak tercapai seperti yang diharapkan. Berdasarkan kenyataan tersebut diperlukan juga pemilihan model pembelajaran yang tepat dan efektif untuk dapat mengembangkan keterampilan berpikir kreatif mahasiswa. Salah satu model pembelajaran yang dapat membantu mahasiswa memperoleh informasi, ide, keterampilan, cara berpikir, dan mengeekspresikan ide diri sendiri dengan menggunakan model Projcet Based Learning (PjBL). Jenis Penelitian menggunakan penelitian tindakan kelas (classroom action research). Penelitian ini dilakukan pada mahasiswa semester V peminatan kesehatan lingkungan yang mengambil matakuliah pengendalian vector dan binatang penganggu yang berjumlah 36 orang. Hasil penelitian didapatkan keterampilan berpikir mahasiswa dalam kategori kreatif pada setiap indikator kelancaran 71,86%, keluwesan 68,1%, merinci 76,34% dan keaslian 77,78% dan hasil belajar mahasiswa meningkat pada tugas proyek individu dan kelompok menjadi 78,5% hasil belajar ini sudah melebihi target yaitu 75%.

Kata kunci: PjBL, Keterampilan berpikir kreatif, hasil belajar
Hubungan Dimensi Servqual dengan Kepuasan Pasien BPJS Kesehatan di Ruang Rawat Inap RS Bhayangkara Jambi Tahun 2021
Authors: Sarah Sarah , Buhari Basok , Maylina Sari Rian 
Published: June 2022

The hospital servqual dimension is very important because it affects patient satisfaction. A good servqual dimension can lead to a sense of satisfaction in each patient. Low customer satisfaction will have an impact on decreasing the number of patient visits which will affect the profitability of health facilities. This study aims to determine the relationship between servqual dimensions and patient satisfaction with BPJS Kesehatan. This study is a quantitative study with a cross sectional research design. The population in this study were all BPJS patients in 2020, which amounted to 2,323 people and sampling was carried out using the accidental sampling technique of 93 people. This research was carried out from 5 to 31 July 2021 in the Inpatient Room at Bhayangkara Hospital Jambi. Data was collected using a questionnaire and the results of this study were analyzed by univariate and bivariate using chi-square statistical test. The results of the analysis show that there is a relationship between the servqual dimension and BPJS health patient satisfaction in the Bhayangkara Jambi Hospital Inpatient Room in 2021 with a P-Value value of 0.000. it is necessary to conduct regular training or training for nurses so that they can contribute to increasing patient satisfaction.
Abstrak
Dimensi servqual rumah sakit sangat penting karena mempengaruhi kepuasan pasien. Kepuasan pelanggan yang rendah akan berdampak terhadap menurunnya jumlah kunjungan pasien yang akan mempengaruhi profitabilitas fasilitas kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan dimensi servqual dengan kepuasan pasien bpjs kesehatan.Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian Cross Sectional. Populasi dalam penelitian ini adalah seluruh pasien BPJS di pada Tahun 2020 yang berjumlah 2.323 orang dan pengambilan sampel dilakukan dengan menggunakan teknik accidental sampling sebanyak 93 orang. Penelitian ini telah dilaksanakan pada tanggal 5 s/d 31 Juli Tahun 2021 di Ruang Rawat Inap RS Bhayangkara Jambi. Pengumpulan data dilakukan dengan kuesioner dan hasil penelitian ini dianalisis secara univariat dan bivariat menggunakan uji statistik chi-square. Hasil analisis menunjukkan bahwa ada hubungan antara hubungan antara dimensi servqual dengan kepuasan pasien BPJS kesehatan dengan nilai p-value 0,000. Kualitas pelayanan dikatakan baik oleh pasien, ditentukan oleh kenyataan apakah jasa yang diberikan bisa memenuhi kebutuhan pasien, dengan menggunakan persepsi pasien tentang pelayanan yang diterima. Didimpulkan bahwa dimensi sevqual berkaitan erat dengan pasien BPJS kesehatan.
Kata kunci : Dimensi Servqual, Kepuasan, Pasien BPJS
Risk Factor Disclosures: Do Managers and Markets Speak the Same Language?
Authors: Filzen Joshua J. , McBrayer Garrett A. , Shannon Kyle S. 
Published: June 2022

SYNOPSIS
Prior research documents market responses to quarterly updates to annual risk factor disclosures, suggesting quarterly risk factor updates are informative. In this study, we explore whether future equity returns are associated with quarterly risk factor updates and whether updates containing more focused and specific language affect this relationship. We find that firms with quarterly risk factor updates experience lower future abnormal returns, relative to firms without updates, suggesting that, on average, the market reaction to quarterly risk factor updates is incomplete at the time the 10-Q is filed. This incomplete market reaction is driven primarily by the group of updates that is important yet is less specific about the effects of the risk on firm fundamentals. We also find that analysts underreact to the same group of risk factor updates associated with the market underreaction.
JEL Classifications: D8; G14; M41; M48.