bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlation between Interleukin-6 and D-dimer, Serum ferritin, CRP in COVID-19 patients
Authors: Al-Hatemy Mohammed , Mohsin Muslim , Al-Roubaey Dina 
Published: June 2022

Background : Severe acute respiratory syndrome coronavirus-2 is the third fatal coronavirus that has emerged in the past two decades, following severe acute respiratory syndrome coronavirus-1 and the Middle East respiratory syndrome coronavirus .
Objective: To investigate the correlation between COVID-19 infection and patient’s descriptive data such as gender, age, and to observe the association of IL-6 and D-dimer, CRP, Serum ferritin in COVID-19 patients.
Methodology: A study is conducted during the period from 1st October 2021 to 1st March 2022, 110 samples are collected from COVID-19 patients, Who attended to AL-Amal Specialized Hospital for Communicable Diseases at first week of infection. Their age range between 15-90 years old, and compared them with 50 healthy individuals as control group. The diagnosis of each case was established using clinical diagnosis and confirmed by reverse transcriptase polymerase chain reaction (PCR). 7 ml of fresh venous blood samples were collected from COVID-19 infected patients for serological and immunological assay for measuring the levels of IL6, D-dimer, serum ferritin, and C-reactive protein.
Results: In the current study, the prevalence of severe COVID-19 infection according to age are increased in older aged patients, the highest one appeared at the (71-90) age group in 100% followed by (51- 70) age group 87.2%, then the low prevalence frequency was recorded at (36-50 ) age group in (37.5%), and the low prevalence 28.6 % at the age group (15-35). From total patients, 79(71.8%) of them were males and 31(28.1%) were females. The mean serum level of ferritin show a significant differences in sera of patient with COVID-19 as compared with control groups (392.4 vs. 131.6 µg/l), as well as, the mean serum level of CRP show a highly significant difference in sera of patient with COVID-19 as compared with control groups (59.26 vs. 7.61 mg/L), also the mean serum level of D-dimer show a highly significant difference in sera of patient with COVID-19 as compared with control groups (1104 vs. 220 ng/ml). The mean serum level of IL-6 show a highly significant difference in sera of patient with COVID-19 as compared with control groups (130 vs. 9.2 pg/ml), also it show a highly significant differences in severe and severe with death cases when compared with control groups, in addition, COVID-19 patients show a significant positive correlation of IL-6 with CRP, Ferritin, and D-dimer by their r values.
Conclusions: The prevalence of severe COVID-19 infection according to age are increased in older aged patients, the male show high infected percentage than female. An elevated serum level of IL-6, CRP, D-dimer, and ferritin are associated with a poor outcome in COVID-19 patients.
The Concept of Islamic Literature and Islamization of Literature through the Different ages
Authors: Al Azhari Sanaullah 
Published: June 2022

Islamic literature is a term referring to the school of thought who believes that a good literary work should view God, man and the world through the lens of Islam. It is conceived that the style of such literature must be of high quality with the Qur’ān, Ḥadith and the legacy of the Islamic scholars being its model. Islamic literature is a universal literature and can be written in any language. However, most of what has been written on the theory and practice of Islamic literature is in Arabic. This study discusses the model of Islamic literature in era of Islam, Umayyad period, Abbasid period, and Modern world. Topics of Islamic literature in modern times are dealing with the moral values ​​in the Qur’ān and the Sunnah of the Prophet, peace be upon him. It discusses Jurisprudence in worship Biography of the Prophet and Praise of the Prophet and his companions God bless them all. The deep knowledge of Arabic language and Islamic literature solves the social and cultural problems around the world.
Analisis Permasalahan Guru dalam Menerapkan Media Pembelajaran pada Mata Pelajaran Fisika di MAN 1 Tanjung Jabung Barat
Authors: Asmita Asmita , Dela Yulianti  , Dwi Agus Kurniawan  , Maison Maison 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui permasalahan yang dihadapi oleh guru fisika dalam menerapkan media pembelajaran, untuk mengkaji faktor yang mendasari permasalahan, dan untuk mengetahui upaya yang dilakukan guru fisika dalam mengatasi permasalahan tersebut. Jenis penelitian ini adalah penelitian kualitatif deskriptif. Objek penelitian adalah guru fisika di MAN 1 Tanjung Jabung Barat. Teknik pengumpulan data menggunakan metode wawancara. Teknik analisis menggunakan metode Miles dan Huberman. Berdasarkan hasil analisis data penelitian dapat diambil kesimpulan yaitu terdapat dua permasalahan yang dihadapi oleh guru dalam menerapkan media pada mata pelajaran fisika di MAN 1 Tanjung Jabung Barat yakni: pertama, permasalahan dalam merencanakan dan mengembangkan media pembelajaran. Kedua, permasalahan dalam partisipasi siswa dalam mengikuti kegiatan pembelajaran. Terdapat dua faktor yang mendasari permasalahan yakni: pertama, keterbatasan kemampuan guru dalam mengembangkan media pembelajaran. Kedua, keterbatasan siswa dalam memahami pelajaran. Dan terdapat dua upaya yang dilakukan oleh guru untuk mengatasi permasalahan tersebut yakni: pertama, memanfaatkan media pembelajaran yang sudah tersedia. Kedua, mengikuti pelatihan atau seminar yang diadakan perguruan tinggi atau pemerintah setempat.
Rancang Bangun Sistem Optik Metode Laser Speckle Imaging (LSI) Model Backscattering untuk Identifikasi Pupuk Oplosan
Authors: Neneng Fitrya  , Wirman Shabri Putra , Rumzi Mughni 
Published: June 2022

Telah dirancang Sistem Optik Metode Laser Speckle Imaging (LSI) Model Backscattering Untuk Identifikasi Pupuk Oplosan. Rancangan system ini bertujuan membantu petani dalam identifikasi pupuk, hal ini dilakukan kan karena banyak beredar pupuk oplosan di pasaran. System LSI terdiri dari komponen utama yaitu laser sebagai sumber cahaya, sampel dan kamera CMOS sebagai detector cahaya serta ruang kedap cahaya yang terbuat dari akrilik. Sistem ini dilengkapi dengan display Graphical User Interface (GUI) untuk memperlihatkan citra spekel hasil tangkapan kamera. Sampel yang digunakan adalah pupuk urea dan NPK. Pengolahan citra pola spekel menjadi data RGB dilakukan menggunakan bantuan software Matlab R2014a. Sistem yang dirancang memiliki keunggulan dapat membedakan pupuk urea murni dengan oplosan dan NPK murni dengan oplosan. Hasil Sistem identifikasi pupuk urea dan NPK menggunakan metode Laser Speckle Imaging (LSI) model backscattering yang berupa frame pola spekel mampu membedakan sampel pupuk murni dan oplosan yang dapat dilihat dari trend data RGB setiap sampel.
Про одну властивість середніх арифметичних коливань монотонної послідовності
Authors: Korenovsky A. O. , Shanin R. V. 
Published: June 2022

УДК 517.5Для числової послiдовностi

Y
=
{

y
i

}

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=
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(номери

P
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∈
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фiксованi,

P
<
Q

) розглянуто середнi арифметичнi коливанняде — середнє арифметичне значення послiдовностi

Y

на вiдрiзку

[
p
,
q
]

,

, номери

P
≤
p
<
q
≤
Q

довiльнi. Такi коливання збiгаються iз середнiми iнтегральними коливаннями функцiї

f
Y

=

∑

i
=
P
+
1

Q

y
i

χ

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— характеристична функцiя множини

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на вiдрiзках iз цiлочисловими межами.Основний результат роботи полягає в тому, що для монотонної послiдовностi Y справджується рiвнiсть

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взяти

f
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i, вiдповiдно, арифметичнi коливання замiнити середнiми iнтегральними коливаннями, а також вважати число

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у правiй частинi не обов’язково цiлим, то отриманий аналог такої рiвностi є вiдомим.
THE EFFECT OF PAST COVID-19 INFECTION ON EARLY PREGNANCY LOSSES
Authors: SOYSAL Çağanay , YİLMAZ Elif 
Published: June 2022

Aim: The aim of this study was to investigate the effect of Covid-19 infection on early pregnancy losses within one year before pregnancy.
Material-Method: The study is a prospective descriptive study that was carried out between 01.03.2021 and 01.09.2021, in the Obstetrics Outpatient clinic of the Obstetrics and Gynecology Department of Ankara Dr. Sami Ulus Gynecology, Child Health, and Diseases Training and Research Hospital. Among the pregnant women between the ages of 18-35 who came for their first control due to obstetric follow-up, the pregnant women in the first trimester who stated that they had Covid-19 infection within one year before pregnancy, were in the study group (n=150), and the pregnant women in the first trimester who did not have a history of Covid-19 infection before pregnancy was also included in the control group (n=150). The pregnant women were followed up to the 20th gestational week and the early pregnancy loss rates of the two groups (spontaneous abortion at 0.05). In the study group, it was determined that the pregnant women who did not experience a pregnancy loss had an average of 6.04±2.94 months before pregnancy, and the pregnant women who had a pregnancy loss had an average of 6.75±3.15 months before the Covid-19 infection, and no statistically significant difference was observed (p>0, 05).
Conclusion: Although there was no relationship between pre-conceptional Covid-19 infection and early pregnancy loss in the study, considering the effect of Covid-19 infection on placental vasculopathy, its relationship with early pregnancy loss should be clarified with larger prospective studies. In this regard,expectant mothers should be guided and their anxiety should be ameliorated at least in the pre-pregnancy period.
Effects of Cinnamon on VEGF and NF-κB Immunoreaction in The Lung Tissue of Rats with Experimentally Induced Diabetes
Authors: ERTUĞRUL Tuğrul , SEVİLGEN Gökçen 
Published: June 2022

Objective: Diabetes mellitus is a metabolic disorder described as hyperglycemia induced by insulin deficiency or resistance. Increasing evidence in studies has shown that the lung is the target of diabetic complications. According to traditional medicine theories, cinnamon is considered a supportive treatment method for diabetics. The aim of this study is to investigate the effect of cinnamon on the immunohistochemical expression of VEGF and NF-κB in lung tissue of streptozotocin-induced experimental diabetic rats.
Material and Method: Thirty-two male rats were randomly divided into four groups: Diabetes, Diabetes + cinnamon, Cinnamon, and Control. The immunohistochemical expression of VEGF and NF-κB in the lung tissue was determined by using the streptavidin-biotin complex method.
Results: It was determined that while cinnamon application alone did not change VEGF expression in lung tissue, the decreased VEGF expression in the diabetes group increased with the cinnamon application. When the immunostaining in the groups was examined no difference was observed in NF-κB immunoreaction between the control and cinnamon groups. As a remarkable finding, in the diabetic group's lung tissue, there were strong positive NF-κB reactions. In addition, a weak positive NF-κB reaction was detected in the diabetes+cinnamom group.
Conclusion: As a result, in our study cinnamon caused decreased the increase in NF-κB expression caused by diabetes and increased the decreased VEGF expression. In conclusion, we believe that this study will be useful in understanding possible cytokine mechanism changes that may occur in the lung tissue due to diabetes and in the development of treatment methods.
Inverse Multiview. I. Multicalibrator Inverse Phase Referencing for Microarcsecond Very Long Baseline Interferometry Astrometry
Authors: Hyland L. J. , Reid M. J. , Ellingsen S. P. , Rioja M. J. , Dodson R. , Orosz G. , Masson C. R. , McCallum J. M. 
Published: June 2022

Abstract
Very Long Baseline Interferometry (VLBI) astrometry is a well established technique for achieving ±10 μas parallax accuracies at frequencies well above 10 GHz. At lower frequencies, uncompensated interferometer delays associated with the ionosphere play the dominant role in limiting the astrometric accuracy. Multiview is a novel VLBI calibration method, which uses observations of multiple quasars to accurately model and remove time-variable, directional-dependent changes to the interferometer delay. Here we extend the Multiview technique by phase-referencing data to the target source (“inverse Multiview”) and test its performance. Multiple observations with a four-antenna VLBI array operating at 8.3 GHz show single-epoch astrometric accuracies near 20 μas for target–reference quasar separations up to about 7°. This represents an improvement in astrometric accuracy by up to an order of magnitude compared to standard phase-referencing.
Testing Horndeski Gravity from EHT Observational Results for Rotating Black Holes
Authors: Afrin Misba , Ghosh Sushant G. 
Published: June 2022

Abstract
The Event Horizon Telescope (EHT) collaboration recently unveiled the first image of the supermassive black hole M87*, which exhibited a ring of angular diameter θ

d
= 42 ± 3 μas, a circularity deviation of ΔC ≤ 0.1, and also inferred a black hole mass of M = (6.5 ± 0.7) × 109
M
⊙. This provides a new window onto tests of theories of gravity in the strong-field regime, including probes of violations of the no-hair theorem. It is widely believed that the Kerr metric describes astrophysical black holes, as encapsulated in the critical but untested no-hair theorem. Modeling Horndeski gravity black holes—with an additional hair parameter h besides the mass M and spin a of the Kerr black hole—as the supermassive black hole M87*, we observe that to be a viable astrophysical black hole candidate, the EHT result constrains the (a, h) parameter space. However, a systematic bias analysis indicates that rotating Horndeski black hole shadows may or may not capture Kerr black hole shadows, depending on the parameter values; the latter is the case over a substantial part of the constrained parameter space, allowing Horndeski gravity and general relativity to be distinguishable in the said space, and opening up the possibility of potential modifications to the Kerr metric.
Circular Polarization Observations of Type II Solar Radio Bursts and the Coronal Magnetic Field
Authors: Ramesh R. , Kathiravan C. , Chellasamy E. Ebenezer 
Published: June 2022

Abstract
It is well known that magnetic field strength (B) in the solar corona can be calculated using the Alfvén Mach number (M

A
) and Alfvén speed (v

A
) of the magnetohydrodynamic shock waves associated with coronal type II radio bursts. We show that observations of weak circularly polarized emission associated with the harmonic component of the type II bursts provide independent and consistent estimates of B. For the coronal type II burst observed on 2021 October 9, we obtained B ≈1.5 G and ≈1.9 G at a heliocentric distance (r) of ≈1.8 R
⊙, using the above two techniques, respectively.
Immunomodulatory Effects of Cermai Leaves (Phyllanthus acidus (L.) Skeels) Ethanol Extract on Normal Male Rats and Cyclophosphamide Induction
Authors: Nurfadhilah Dhea , Yuandani Yuandani , Hasibuan Poppy Anjelisa Zaitun 
Published: June 2022

BACKGROUND: Ethanol extract of Phyllanthus acidus (L.) Skeels leaf contains flavonoids and saponins that were widely used as herbal medicinal plant. The present study focused on exploring the biological potential as well as immunomodulatory effects.

AIM: The present study aimed to investigate the immunomodulatory effects of P. acidus extract on total and differential leukocyte count, antibody titer, delayed-type hypersensitivity (DTH) response in normal male rats, and immunosuppressed male rats.

METHODS: P. acidus extract was obtained by maceration technique by using ethanol as a solvent. Standardization of P. acidus and phytochemical screening includes examination of alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids. The trial animals were male rats which were divided into two large groups, namely normal group and immunosuppressed group. All animals were given extract on the 1st day until day 14, on 4th day the animals were infected with 2% sheep red blood cells. Immunosuppressed rats were injected by 70 mg/kg bw cyclophosphamide on 8th and 13th day. The immunomodulatory effect was analyzed by evaluating total leukocytes, leukocyte differential, antibody titer, and DTH.

RESULTS: Phytochemicals screenings were showed alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids from P. acidus extract. P. acidus extract showed an immunomodulatory activity on normal male rats and immunosuppressed male rats. The result was shown from the increasing of total leukocyte count and leukocyte differential, antibody titer value, and the volume of rat paws were higher than negative control (p < 0.05).

CONCLUSION: The results indicated that the P. acidus extract had immunomodulatory effects and its potential to be developed as immunomodulator agent.
Perilipin Genetic Variation Correlated with Obesity and Lipid Profile in Metabolic Syndrome
Authors: Hastuti Pramudji , Mus Rosdiana , Puspasari Anggelia , Maharani Citra , Setyawati Ika 
Published: June 2022

BACKGROUND: Perilipin is very important for the regulation of the deposition and mobilization of fats. The human perilipin gene (PLIN) is near the locus for risk of obesity and hypertriglyceridemia. The PLIN gene is thought to be involved in the occurrence of metabolic syndrome.

AIM: The aim of this research is to determine the role of variations of the PLIN gene (PLN4 11482 G>A) as a risk factor for component of metabolic syndrome.

METHODS: This study involved a total of 160 subjects consisting of 80 with metabolic syndrome and 80 controls. Genotype analysis was done with the polymerase chain reaction-restriction fragment length polymorphism method. The data were analyzed with t-tests to compare the subjects’ characteristics between metabolic syndrome groups and controls. Risk factors of PLIN genotypes were calculated with odds ratio and multivariate regression analysis was used to determine the role of the PLIN gene with each biochemical characteristic.

RESULTS: The result was significant differences between the characteristics of the metabolic syndrome subjects with controls (p < 0.05). There was no difference in genotypes between patients with metabolic syndrome and controls. The multivariate analysis of the genetic role with biochemical components showed the PLIN gene in AA carriers as a risk factor for metabolic syndrome compare GA+GG, risk of obesity, and hypercholesterolemia with p < 0.05.

CONCLUSION: It can be concluded that PLIN variation has a role in the incidence of metabolic syndrome, especially in relation to obesity and hypercholesterolemia. Further study is needed to determine the role of other gene variations as a risk factor for metabolic syndrome.
Ectopic Pregnancy Following Levonorgestrel Emergency Contraception: Report of Two Cases
Authors: Telbiyska Katia , Angelova Mariya 
Published: June 2022

Abstract
Ectopic pregnancy (EP) is likely to occur as an unwanted complication after unprotected intercourse in spite of levonorgestrel emergency contraception (LNG-EC). Its incidence has been increasing recently.
We present 2 cases of tubal EP after the oral use of levonorgestrel, treated by laparoscopy.The first unruptured EP with unclear ultrasound findings, because of uterine ventrofixation after the caesarean section (CS) . The second case is a ruptured EP after LNG –EC on day 24 of the period with mild haemoperitoneum with severe peritoneal irritation.
The fundamental question is whether levonorgestrel participates in the etiology of EP.
The etiology of EP involves many factors. Levonorgestrel mechanisms of action give us grounds to believe theoretically that it increases the risk of EP and participates as an etiological factor.
Searching for novel antagonists of adenosine A1 receptors among azolo[1,5-a]pyrimidine nitro derivatives
Authors: Yakovlev Dmitry S. , Vassiliev Pavel M. , Agatsarskaya Yana V. , Brigadirova Anastasia A. , Sultanova Kira T. , Skripka Maria O. , Spasov Alexander A. , Savateev Konstantin V. , Rusinov Vladimir L. , Maltsev Dmitriy V. 
Published: June 2022

Introduction: Ligands of adenosine A1Rs are potential candidates for the development of drugs for the treatment of paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At the same time, there is a deficiency of drugs that can regulate the functions of A1 receptors. A number of A1-antagonists are at the various stages of clinical trials; other drugs are not very selective or are characterized by an insufficient breadth of their therapeutic action. Therefore, the search for new medicinal compounds for the prevention and treatment of A1-depended diseases among nitro derivatives of tetrazolo[1,5-a]pyrimidine and 1,2,4-triazolo[1,5-a]pyrimidine is of scientific interest.
Materials and methods: The search for active compounds was carried out by in silico and in vitro methods. At the first stage, a computer forecast of A1-antagonistic activity was carried out using the Microcosm BioS software. At the second stage, the prediction results were verified in vitro in a model of isolated mouse atria.
Results and discussion: Based on the results of the prediction by the method of maximum similarity to standards, the most active compounds III, VIII, and XVII were selected. After testing the prediction results by the isolated atria method, the compound VIII was characterized by A1-blocking effect in vitro at a concentration of 10 μmol/L.
Conclusion: The most promising compound with A1-blocking effect in vitro was identified; it is a derivative of tetrazolo[1,5-a]pyrimidine under the code of VIII. It is of interest for us for further in-depth study of its pharmacological properties.
Estrategia didáctica para el desarrollo del lenguaje oral en los niños y niñas del nivel preescolar
Authors: Pinargote Macías Sandra Yadira , Hipatia Alexandra Meza Intriago 
Published: June 2022

La adquisición del lenguaje es un proceso natural del desarrollo de un niño o niña, el reconocimiento de un retraso en la adquisición del lenguaje en etapa temprana permitirá a un especialista actuar y modificar de manera significativa el aprendizaje del lenguaje. Este artículo se basa en una propuesta educativa, mediante un plan de acción basado en estrategia didáctica para lograr aprendizajes que permitan el desarrollo del lenguaje oral en los niños y niñas del Centro de Educación Inicial Agripina Murillo de Guillem de Ecuador. Este estudio se sustenta en cuatro fases: desde el diagnóstico hasta la valoración de los descriptores. Mediante la ejecución se reflejó que los niños y niñas necesitan estimulación para el desarrollo del lenguaje oral, actividades como imitación, canciones y trabalenguas, tareas de discriminación auditiva y la interacción social.