bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Telemedicine Using Videoconferencing Systems in Outpatient Care for Patients With Cancer: A Systematic Review and Meta-Analysis
Authors: Uemoto Yasuaki , Yamanaka Taro , Kataoka Yuki , Wada Yoshitaka , Aoyama Yosuke , Kizawa Rika , Yamaguchi Takeshi , Kikawa Yuichiro , Mukai Hirofumi , Taira Naruto 
Published: November 2022

PURPOSE This systematic review aimed to investigate the efficacy of telemedicine (TM) using videoconferencing systems in outpatient care for patients with cancer. METHODS We searched six electronic databases (CENTRAL, MEDLINE, EMBASE, CINAHL, ICTRP, and ClinicalTrials.gov) through June 2021 to identify randomized controlled trials that evaluated the use of TM using videoconferencing systems compared with usual face-to-face care in outpatient care for patients with cancer. We assessed the certainty of evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation. RESULTS From the 2,400 articles screened, six randomized controlled trials were eligible for this study. Two studies evaluated the use of TM in cancer follow-up and four investigated psychotherapy for cancer. TM using videoconferencing systems may result in no differences in primary outcomes such as patient satisfaction (standardized mean difference, 0.11; 95% CI, –0.18 to 0.40) and outpatient attendance complete proportion (risk difference, 0.02%; 95% CI, –0.04 to 0.09), and secondary outcomes such as medical professional satisfaction, time devoted to outpatient care, and depression score. The certainty of evidence for these outcomes was low. Although the average money spent on outpatient visit was a primary outcome, the level of evidence was uncertain. CONCLUSION Our results suggest that TM using videoconferencing systems in outpatient care for patients with cancer may be as effective as usual face-to-face care. Use of TM more frequently may be considered for patients with cancer who are expected to obtain benefit from TM using videoconference systems.
Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD)
Authors: Hardy Janet , Greer Ristan , Huggett Georgie , Kearney Alison , Gurgenci Taylan , Good Phillip 
Published: November 2022

PURPOSE To determine whether cannabidiol (CBD) oil can improve symptom distress in patients with advanced cancer receiving palliative care. METHODS Participants were adults with advanced cancer and symptom distress (Edmonton Symptom Assessment Scale [ESAS] total score of ≥ 10/90) who received titrated CBD oil 100 mg/mL, 0.5 mL once daily to 2 mL three times a day, or matched placebo for 28 days. The primary outcome was ESAS total symptom distress score (TSDS) at day 14. Response was defined as a decrease in TSDS by ≥ 6 at day 14. Secondary outcomes were ESAS TSDS over time, individual symptom scores, patient-determined effective dose, opioid use, Global Impression of Change, depression, anxiety, quality of life, and adverse events. RESULTS Of the 144 patients randomly assigned, the planned sample size of 58 participants on CBD and 63 on placebo reached the primary analysis point (day 14). The unadjusted change in TSDS from baseline to day 14 was –6.2 (standard deviation, 14.5) for placebo and –3.0 (standard deviation, 15.2) for CBD with no significant difference between arms ( P = .24). Similarly, there was no detected difference in proportion of responders (placebo: 37 of 63 [58.7%], CBD: 26 of 58 [44.8%], P = .13). All components of ESAS improved (fell) over time with no difference between arms. The median dose of participant-selected CBD was 400 mg per day with no correlation with opioid dose. There was no detectable effect of CBD on quality of life, depression, or anxiety. Adverse events did not differ significantly between arms apart from dyspnea that was more common with CBD. Most participants reported feeling better or much better at days 14 (53% CBD and 65% placebo) and 28 (70% CBD and 64% placebo). CONCLUSION CBD oil did not add value to the reduction in symptom distress provided by specialist palliative care alone.
PLA2G6-Associated Neurodegeneration: A Rare Case Report of Neurodegeneration with Brain Iron Accumulation in Children
Authors: Widianti Nurani , Hanindita Meta Herdiana , Widjaja Nur Aisiyah , Irawan Roedi 
Published: November 2022

This report aimed to describe and review the clinical features, neuroimaging findings, and PLA2G6 mutations identified in a 34-month-old girl with regression of developmental milestones.A 34 months old girl came to Dr.Soetomo Hospital’s outpatient clinic, Surabaya, with a developmental regression for six months, and got worse until she could not do any activity and was followed by recurrent seizures. She had a sibling who had similar problems and symptoms and then died at five years of age. The head MRI revealed brain atrophy, the possibility of an early sign of metabolic disorder, and a white matter lesion at the globuspallidus bilateral that supports the encephalopathy metabolic view. The genetic test revealed a positive homozygous such as a pathogenic variant in the PLA2G6 gene, which confirmed the diagnosis. PLA2G6-Associated with Neurodegeneration (PLAN) should be considered as a diagnosis in children with developmental regression.
doi: https://doi.org/10.12669/pjms.39.1.6801
How to cite this: Widianti N, Hanindita MH, Widjaja NA, Irawan R. PLA2G6-Associated Neurodegeneration: A Rare Case Report of Neurodegeneration with Brain Iron Accumulation in Children. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6801
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Knowledge about kitchen hygiene and associated factors in caregivers in a peri-urban area of Lima
Authors: Lozada-Urbano Michelle , Miranda Doris , Huamán Franklin , Chirinos-Cáceres Jesus , Rivera-Lozada Oriana 
Published: November 2022

Background: Food and kitchen hygiene are necessary conditions for safe food and prevent foodborne illnesses. The objective of this study was to identify the factors associated with caregivers’ knowledge of kitchen hygiene in San Juan de Lurigancho (SJL). Methods: This was a cross-sectional study. We surveyed 250 mothers at comedores populares (a sort of community kitchens which are very popular in Lima) and who were part of mothers' clubs in the areas of Huascar V and San Pablo, in SJL in Lima. The sample was selected through non-probability convenience sampling. A questionnaire with three dimensions (cleanliness, storage and contamination of children) was administered. Results: On average, in Huascar and San Pablo, most caregivers were the children’s mothers (93.2%); most of the caregivers were between 21 and 30 years old (54%); they had secondary level of education (70.4%); they were living in free union with their partners (69.2%); they were mainly housewives (80.4%); their houses were constructed with materials different from brick and cement (68.4%); and their houses had a bare floor (70.0%). They did not have drinking water in the kitchen (88.4%); they did not use a gas stove (88.4%), a refrigerator (50.0%), a radio (82.0%), or a microwave (16.4%). A good level of knowledge of food hygiene was found in 63.2% of caregivers. No predictive capacity of the assessed sociodemographic characteristics on the level of knowledge of kitchen hygiene was identified. Conclusions: This study determined that the assessed sociodemographic variables were not significantly associated with the level of knowledge about kitchen hygiene. It is necessary to improve mothers' knowledge about the handling and consumption of spoiled food and their effect on children's health.
Grey area nursing: high-dependency nurses’ experiences of caring for patients approaching the transition from curative to palliative care
Authors: Johnson Emily , Jack Barbara 
Published: November 2022

Background: Nurses in high-dependency units frequently facilitate the withdrawal of life-sustaining treatments and provide end-of-life care. Providing this care has been shown to cause distress, burnout and cumulative grief. There remains a lack of understanding of high dependency nurses’ experiences of caring for patients approaching withdrawal of life-sustaining treatments. Aim: To explore experiences of high dependency nurses caring for patients approaching withdrawal of life-sustaining treatment and highlight any support or needs they may have. Methods: Interviews were conducted and analysed using qualitative thematic analysis. Findings: Nurses experienced conflict in decision making, which was reported to prolong patient distress and cause nurses moral anguish. Nurses need time to talk and further education to support them to provide withdrawal of life-sustaining treatment. Conclusion: High-dependency nurses need time to talk following caring for this patient group and more extensive education to support them to provide quality end-of-life care.
Attitudes of ward nurses towards the administration of ‘as required’ injectable medications for symptom control at the end of life
Authors: Hirsch Christine , Hall Elke , Shah Fatimah , Tomas Jon 
Published: November 2022

Background: It is recognised good practice to prescribe ‘as required’ parenteral medication (ARPM) to provide individualised symptom control in the final days of life. The decision to administer the medication and, sometimes, to decide the dose, usually lies with the nurse. Aims: To explore attitudes towards administration of ARPM at end of life (EOL) among hospital nurses. Methods: The views of registered nurses, recruited from wards with high death rates, were explored through questionnaires and semi-structured interviews. Questionnaire responses were coded and statistically analysed. Interviews were recorded, transcribed, manually coded and thematically analysed. Results: Almost 50% of questionnaire respondents (n=62) reported feeling ‘very confident’ in recognising symptoms at the EOL. Only 39% of respondents reported undertaking specific training. Three main themes emerged through the interviews: experience; factors influencing the decision to administer ARPM; and education. Conclusion: Wider accessibility to training may support confident decision making by hospital nurses administering ARPM at the EOL.
The introduction of a palliative care link nurse programme to improve nurses’ attitudes, knowledge and confidence in providing end-of-life care in an acute care setting
Authors: Bruno Melissa 
Published: November 2022

Background: Providing end-of-life (EOL) care in the acute care setting has been challenging, with clinicians focused on curative treatments and prolonging life, while few nurses are receiving adequate training and support in caring for the dying. Aims: To assess if the introduction of a palliative care link nurse programme (PCLNP) improved nurses’ confidence in providing EOL care in the acute care setting. Methods: A total of 40 acute care nurses attended a full-day education session on core topics, followed by regular 3-monthly educational meetings. Participants were provided with ongoing support and mentoring and required to complete quality improvement activities. A mixed-research methodology was used. Findings: The PCLNP had a positive impact on nurses’ attitudes towards death and dying, and increased levels of comfort in providing EOL care to patients and supporting families. Nurses completed clinical audits and provided education to their colleagues. Conclusions: EOL care in this setting must be improved for both patients and their families. This programme has shown an increase in nurses’ knowledge and comfort level in providing EOL care. Further research into determining the direct impact on patient care and families is required.
Whole-body radiation exposure in Trauma and Orthopaedic surgery
Authors: Hurley Robert J. , McCabe Fergus J. , Turley Luke , Maguire Danielle , Lucey Julie , Hurson Conor J. 
Published: November 2022

Aims The use of fluoroscopy in orthopaedic surgery creates risk of radiation exposure to surgeons. Appropriate personal protective equipment (PPE) can help mitigate this. The primary aim of this study was to assess if current radiation protection in orthopaedic trauma is safe. The secondary aims were to describe normative data of radiation exposure during common orthopaedic procedures, evaluate ways to improve any deficits in protection, and validate the use of electronic personal dosimeters (EPDs) in assessing radiation dose in orthopaedic surgery. Methods Radiation exposure to surgeons during common orthopaedic trauma operations was prospectively assessed using EPDs and thermoluminescent dosimeters (TLDs). Normative data for each operation type were calculated and compared to recommended guidelines. Results Current PPE appears to mitigate more than 90% of ionizing radiation in orthopaedic fluoroscopic procedures. There is a higher exposure to the inner thigh during seated procedures. EPDs provided results for individual procedures. Conclusion PPE currently used by surgeons in orthopaedic trauma theatre adequately reduces radiation exposure to below recommended levels. Normative data per trauma case show specific anatomical areas of higher exposure, which may benefit from enhanced radiation protection. EPDs can be used to assess real-time radiation exposure in orthopaedic surgery. There may be a role in future medical wearables for orthopaedic surgeons. Cite this article: Bone Jt Open 2022;3(11):907–912.
Prevalence and determinants of wasting of under-5 children in Bangladesh: Quantile regression approach
Authors: Hossain Md. Moyazzem , Abdulla Faruq , Rahman Azizur 
Published: November 2022

Background
Wasting is perhaps one of the signs of malnutrition that has been linked to the deaths of children suffering from malnutrition. As a result, understanding its correlations and drivers is critical. Using quantile regression analysis, this research aims to contribute to the discussion on under-5 malnutrition by analyzing the predictors of wasting in Bangladesh.

Methods and materials
The dataset was extracted from the 2017–18 Bangladesh demographic and health survey (BDHS) data. The weight-for-height (WHZ) z-score based anthropometric indicator was used in the study as the target variable. The weighted sample constitutes 8,334 children of under-5 years. However, after cleaning the missing values, the analysis is based on 8,321 children. Sequential quantile regression was used for finding the contributing factors.

Results
The findings of this study depict that the prevalence of wasting in children is about 8 percent and only approximately one percent of children are severely wasted in Bangladesh. Age, mother’s BMI, and parental educational qualification, are all major factors of the WHZ score of a child. The coefficient of the female child increased from 0.1 to 0.2 quantiles before dropping to 0.75 quantile. For a child aged up to three years, the coefficients have a declining tendency up to the 0.5 quantile, then an increasing trend. Children who come from the richest households had 16.3%, 3.6%, and 15.7% higher WHZ scores respectively than children come from the poorest households suggesting that the risk of severe wasting in children under the age of five was lower in children from the wealthiest families than in children from the poorest families. The long-term malnutrition indicator (wasting) will be influenced by the presence of various childhood infections and vaccinations. Furthermore, a family’s economic position is a key determinant in influencing a child’s WHZ score.

Conclusions
It is concluded that socioeconomic characteristics are correlated with the wasting status of a child. Maternal characteristics also played an important role to reduce the burden of malnutrition. Thus, maternal nutritional awareness might reduce the risk of malnutrition in children. Moreover, the findings disclose that to enrich the nutritional status of children along with achieving Sustainable Development Goal (SDG)-3 by 2030, a collaborative approach should necessarily be taken by the government of Bangladesh, and non-governmental organizations (NGOs) at the community level in Bangladesh.
THE MARKET OF SPA SERVICES: PROBLEMS AND PROSPECTS OF DEVELOPMENT
Authors: Balashova S. P. 
Published: November 2022

The sanatorium complex is a promising and significant component of the social and economic spheres of the state. The activities of its organizations are directly related both to participation in the process of preserving the health of the population, and the formation of the gross domestic product, ansuring effective employment, and increasing incomes at all levels.
The quality and variety of health resort services provided must correspond to the first-class level that is necessary to meet the needs of citizens. The expansion of the complex of sanatorium-resort organizations and the improvement of the quality of the services they provide will promote natural competition between them, which will have a positive impact on the market in this area in the future.
In the article analyzes the state of the health resort complex in Russia and its further development. Problems and specific features of the market of sanatorium and resort services are revealed, the structure of their regional market is characterized. The main tendencies of the market of sanatorium-and-spa services are determined.
HERITAGE ASSETS: RECONHECIMENTO, MENSURAÇÃO E EVIDENCIAÇÃO EM MUSEUS
Authors: Pires Charline , Niyama Jorge Katsumi , Beuren Ilse Maria , Ott Ernani 
Published: November 2022

Objetivos: O estudo objetiva investigar a forma como os heritage assets são reconhecidos, mensurados e evidenciados pelos museus.
Método: Uma pesquisa documental foi realizada com abordagem quantitativa. Analisaram-se as demonstrações contábeis de 42 museus australianos, 25 neozelandeses e 171 ingleses, totalizando uma amostra de 238 entidades. Os dados foram analisados considerando-se as dimensões definidas conforme os itens apresentados das normas AASB 116, PBE IPSAS 17 e FRS 102.
Resultados: Os resultados da análise documental revelaram a adoção de diferentes práticas, seja quando observados os museus de um mesmo país, ou quando da comparação entre os países. Na Austrália predominaram museus que capitalizam seus heritage assets de forma plena, enquanto que no Reino Unido a maioria dos museus adotou a abordagem mista ou não reconheceram esses ativos. A Nova Zelândia, por sua vez, apresenta um cenário intermediário, com entidades divididas entre essas duas possibilidades.
Contribuições: O estudo contribui para a compreensão dos limites de aplicação dos padrões vigentes, levando a reflexões sobre os tratamentos mais adequados no contexto das organizações investigadas.
Palavras-chave: Heritage assets. Reconhecimento. Mensuração. Evidenciação.
(IN)COMPREENSIBILIDADE DAS DEMONSTRAÇÕES FINANCEIRAS DOS MUNICÍPIOS BRASILEIROS PELOS USUÁRIOS EXTERNOS
Authors: Camacho Eliane Utrabo , Weffort Elionor Farah Jreige , Garcia Alexandre Sanches , Gonçalves Andreá de Oliveira 
Published: November 2022

Objetivo: O estudo analisa as variáveis associadas à compreensibilidade das demonstrações financeiras do setor público a partir da percepção dos usuários externos das informações.
Método: Foram selecionadas variáveis associadas à compreensibilidade e desenvolvido um questionário eletrônico que permitisse observá-las. Foram obtidas 415 respostas válidas em uma amostra de cidadãos brasileiros. A análise foi realizada de forma qualitativa e quantitativa por meio de teste de relações entre as variáveis, em especial, análise confirmatória.
Resultados: Apontaram relações estatisticamente significativas entre a compreensibilidade das demonstrações e as variáveis: grau de escolaridade, formação acadêmica, ocupação e autoavaliação em conhecimento sobre a contabilidade do setor público. Foi encontrada ainda relação entre a legibilidade, medida pelo teste de Flesch, o grau de escolaridade do respondente e a compreensibilidade das informações, corroborando com a literatura sobre este tema, ainda que majoritariamente voltada aos relatórios de entidade do setor privado.
Contribuições: O estudo preenche uma lacuna na literatura nacional e internacional sobre compreensibilidade das informações contábeis, precipuamente na esfera pública e apresenta como principais contribuições: (i) para pesquisas futuras oferece um instrumento para coleta de dados (questionário) inédito, calcado em sólido arcabouço teórico e validado por uma ampla amostra; (ii) achados inéditos sobre variáveis relacionadas à compreensibilidade não abrangidos ainda em outras pesquisas para o setor público; (iii) evidências que provocam uma reflexão junto ao poder público e à comunidade sobre a necessidade de melhoria na forma de divulgação e comunicação das informações do setor público, bem como, identifica caminhos para tal.
Turn-it-out? Reframing the Academic Integrity Conversation in Online Legal Education
Authors: Bailey Kim , Kalache Lachlan , Acheson Rebecca 
Published: November 2022

The challenge of academic integrity in online study is not a new phenomenon. For undergraduate law students, a finding of academic misconduct is especially serious, having ramifications for student eligibility to be admitted to legal practice. To date, higher education strategies to address plagiarism, contract cheating, and collusion have predominantly focused on detection methodology / technology via assessment. Reconceptualising the challenge of academic integrity in online learning requires an iterative understanding of the motivations of online learners, informed by the unique engagement challenges associated with adult online learning. Arguably, the ‘battle’ for integrity can never be won via increased detection and punitive measures; rather a focus on fostering student desire to act with integrity, by helping learners to connect academic integrity with their emerging professional identity is key. This connection must be supported by profession-facing teaching and assessment design, with facilitated learning relationships that build skills and confidence.
Developing a micro-credential for Learning Designers: A Delphi Study
Authors: MacCallum Kathryn , Brown Cheryl 
Published: November 2022

Teaching and learning online have increased as a consequence of the pandemic. There is an increasing need for learning design proficiency both in terms of new roles and also new expertise. In recognition of this, the Tertiary Education Commission in Aotearoa | New Zealand is supporting the design of a micro-credential to develop introductory knowledge in this field. Given the complexity and breadth of competencies needed in this role determining the foundational components is challenging. Prior research focused on professional standards and employer requirements only capture one perspective of the role. In this Delphi study, we sought the views of thirty-four learning designers to determine the essential competencies required for learning design in the current (post)pandemic context. Findings demonstrate the importance of understanding the nuances of different modes of learning, pedagogy before technology and the value of relationships.