bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do You See What I See? How Media Choice and Visual Tornado Cues Influence Individual Storm Preparation
Authors: Armstrong Cory L. , Usery Anna Grace 
Published: September 2022

Abstract
When a tornado hits, there is little time to think through mental checklists for needed items. This study attempted to understand what information sources those in the path of tornados utilized for preparation and how those sources influence people to act. Results from the study indicate that television and radio are the top two information sources, and that some visual graphics—gauged via heat maps to understand higher levels of severe weather preparation—were reported as useful. Contrary to meteorological intentions, results showed that participants were less likely to prepare for impending weather when radar displayed tornado locations and intensity. In addition, those who identified as having more interest in weather-related information in the study were significantly more likely to prepare, along with those who fear future tornadoes. Each variable explored is underpinned by the theory of planned behavior and the risk information seeking and processing (RISP) model to better understand behavioral intentions and actions. This study offers two new concepts of general weather that have not previously been explored: interest and general versus specific storm preparation.

Significance Statement
The purpose of this work is to learn more about how individuals gather information and obtain weather warnings, primarily during tornado events. In particular, the study seeks to understand how individuals view and interpret visual graphics with information about the location and details about the event. Further, results suggest some differences between those who generally prepare for storm season versus those who only prepare for a specific event. Researchers may also be interested to know how weather enthusiasts may differ in their preparatory activities in comparison with nonweather enthusiasts. All of this information will help meteorologists and media professionals to better target their messages during severe weather.
Surgical Treatment for Empty Nose Syndrome Using Autologous Dermal Fat: Evaluation of Symptomatic Improvement
Authors: Hosokawa Yu , Miyawaki Takeshi , Omura Kazuhiro , Akutsu Taisuke , Kimura Ryohei , Ikezono Tetsuo , Otori Nobuyoshi 
Published: September 2022

Background: Empty nose syndrome (ENS) is caused by nasal turbinate surgery. The standard treatment for ENS is an inferior meatus augmentation procedure (IMAP) in which autologous tissue such as auricular cartilage, rib cartilage, or artificial material is transplanted into the nasal cavity. However, some challenges like a very small auricular cartilage are associated with these autologous tissue types. Moreover, since using rib cartilage is a highly invasive technique, the scar on the chest from where the harvesting is done is easily visible, and the artificial material is susceptible to infection. We used autologous dermal fat (ADF) in IMAPs in our study for the following reasons: the quantity of ADF could be increased or reduced as needed, ADF is considered a safer option than rib cartilage because it is harvested from superficial tissue, it is superior in terms of cosmetic appearance to harvested rib cartilage, and it has a lower risk of infection than any artificial material. Objective: The purpose of our study was to investigate the efficacy and safety of IMAPs using ADF. Methods: We included nine patients with ENS who underwent an IMAP using ADF. The patients’ backgrounds and responses to the Empty Nose Syndrome 6-Item Questionnaire (ENS6Q) were recorded. Changes in each item of the ENS6Q before and after surgery (up to 3 months) were analyzed. Results: The postoperative ENS6Q total score and parameters were significantly better than their preoperative counterparts. Nasal dryness improved slightly less than other symptoms. There were no complications. Conclusions: The IMAP using ADF was effective in improving ENS symptoms; however, some physiological functions were difficult to improve, and dryness persisted. Autologous dermal fat is larger than auricular cartilage, less invasive than rib cartilage, and has a lower risk of infection than artificial material.
A study of the efficacy of sacubitril/valsartan plus dapagliflozin combination treatment in pulmonary arterial hypertension due to left heart disease
Authors: Ge Ting , Yang Yang , Zhao Yanfang 
Published: September 2022

Objective To determine the efficacy of sacubitril/valsartan plus dapagliflozin in the treatment of patients with pulmonary arterial hypertension (PAH) due to left heart disease and to explore new treatment regimen for PAH due to left heart disease. Methods This study is a randomized controlled trial (RCT) study of 120 patients with PAH due to left heart disease admitted to the cardiovascular department of our hospital from Dec. 2019 to Dec. 2021. The patients were randomized 1:1 to the study group and control group. All patients were given baseline treatments targeting left heart disease and symptoms of PAH. In addition to the baseline treatments, patients in the control group were given sacubitril/valsartan tablets, while patients in the study group were given sacubitril/valsartan tablets plus dapagliflozin tablets. After 6 months of treatment, parameters including left heart function and exercise tolerance, Hemodynamics (left ventricular end systolic diameter [LVSED], left ventricular end diastolic diameter [LVEDD], left ventricular ejection fraction [LVEF], 6 min walk distance (6MWD), mean pulmonary artery pressure (mPAP) and pulmonary artery systolic pressure (PASP)), vascular endothelial function (plasma endothelin (ET) −1 and nitric oxide [NO]), heart failure markers (plasma N-terminal pro-brain natriuretic peptide (NT-proBNP)], inflammatory factors (serum C reactive protein [CRP], interleukin (IL)-6, and tumor necrosis factor (TNF)-α], and adverse drug reactions (ADRs) were assessed in both groups. Results Both groups had reduced LVESD and LVEDD, increased LVEF, and extended 6MWD after 6 months of treatment. The improvements in these parameters were significantly greater in the study group than in the control group (all P < 0.05). In addition, both the mPAP and PASP showed a decrease, and the mPAP and PASP in the study group were lower than those in the control group ( p<0.05). Furthermore, both groups had decreased plasma ET-1 and NT-proBNP but increased plasma NO after 6 months of treatment. The improvements in these parameters were significantly greater in the study group than in the control group (all P < 0.05). Serum CRP, IL-6 and TNF-α levels were decreased in both groups after 6 months of treatment, and were significantly lower in the study group than in the control group (all P < 0.05). There was no significant difference in the overall incidence of ADRs between the two groups ( P > 0.05). Conclusion Sacubitril/valsartan plus dapagliflozin in the treatment with PAH due to left heart disease can improve left heart function of patients by improving vascular endothelial functions and alleviating inflammation, which helps to reduce the PAH process. Therefore, this combination treatment is safe and effective in PAH due to left heart disease.
Implication of microglia in ketamine-induced long-term cognitive impairment in murine pups
Authors: Yin Y , Li H , Wang J , Kong Y , Chang J , Chu G 
Published: September 2022

Background Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, is widely applicable to anesthesia, analgesia, and sedation. However, the function and mechanisms of ketamine in the long-term learning and memory function of neonatal mice are unclear. Objective The present study aims to investigate whether long-term learning and memory function will be affected by multiple ketamine exposures in the early development period. Methods The mRNA and protein levels were measured by RT-qPCR and western blot, respectively. The Morris Water Maze test was performed to assess spatial learning and memory. Results We identified that neonatal exposure to ketamine downsized the positive neurons for microtubule-associated protein doublecortin (DCX) and Ki67 in hippocampal dentate gyrus at the juvenile and late adolescence stages. Double-labeling tests demonstrated that the counts of Iba1+ cells and Ki67+ cells were pronouncedly diminished with exposure to ketamine. Further, qPCR assays to screen the key factors predisposing the populations and maturation of microglia exhibited remarkable decline of CX3CR1 mRNA levels in ketamine group versus the control group. The close relation of microglia to synaptic plasticity was depicted by the significantly downregulated synaptic plasticity-related proteins NR2B and PSD-95 subsequent to multiple exposures to ketamine. Finally, we found that both the protein and mRNA levels of BDNF were markedly decreased in ketamine group versus the control group. Conclusion We found that multiple exposures to ketamine in neonatal mice lead to spatial learning and memory dysfunction. The alterations of microglial development and function are the possible mechanisms of long-term learning and memory impairment.
Australian healthcare workers experiences of peer support during COVID-19: Hand-n-Hand peer support
Authors: Musgrove Erica , Bil Daniel , Bridson Tahnee , McDermott Brett 
Published: September 2022

Introduction Founded at the beginning of the COVID-19 pandemic, Hand-n-Hand Peer Support (HnH) offers free, confidential peer support to healthcare workers (HCWs) across Australia and New Zealand. This survey aimed to evaluate HCWs experiences of peer support and collect demographic data about what groups of HCWs were seeking support. Methods An online survey was conducted in November 2021 of HCWs who were either active or past HnH participants ( n = 158). Questions included 5-point Likert scales, multiple choice and free text responses. Results We received 66 responses (42% response rate). The median age range of respondents was 41–45 years and most were female (87.9%). Most respondents (57.4%) reported experiencing no barriers to accessing peer support. The vast majority (81.4%) of HCWs reported a ‘good’ or ‘very good’ peer support experience. Respondents felt peer support helped in multiple ways, particularly in feeling less alone and having a safe space to discuss issues. Conclusion Australian HCWs accessing peer support tended to be female and more senior clinicians. Most HCWs engaged in HnH reported overall very positive experiences. Our survey helped to identify several areas for improvement in HnH, including clearer marketing about peer support and more targeted triage assessments.
Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer
Authors: Sun Yu , Zhao Jun 
Published: September 2022

Background: Cancer is the leading cause of death in the world. The mechanism is not fully elucidated and the therapeutic effect is also unsatisfactory. In our study, we aim to find new target gene in pan-cancer. Methods: Differently expressed genes (DEGs) was screened out in various types of cancers from GEO database. The expression of DEG (TCEAL2) in tumor cell lines, normal tissues and tumor tissues was calculated. Then the clinical characteristics, DNA methylation, tumor infiltration and gene enrichment of TCEAL2 was studied. Results: TCEAL2 expressions were down-regulated in most cancers. Its expression and methylation were positively or negatively associated with prognosis in different cancers. The tumor infiltration results revealed that TCEAL2 was significantly related with many immune cells especially NK cells and immune-related genes in majority cancers. Furthermore, tau protein and tubulin binding were involved in the molecular function mechanisms of TCEAL2. Conclusion: TCEAL2 may be a novel prognostic marker in different cancers and may affect tumor through immune infiltration.
Reconstructing authenticity through a multi-paradigmatic umbrella: A process perspective
Authors: Vendette Sebastien , Helmuth Catherine A , Intindola Melissa L , Spiller Chellie 
Published: September 2022

While there is a substantive body of research that recognizes the importance of authentic leadership theory, critiques have challenged its dominant and positive-focused conceptualization. We synthesize these extant critiques, providing researchers with an integrative understanding of the theoretical, conceptual, and empirical deficiencies facing authenticity in a leadership context. These deficiencies have thwarted authentic leadership’s development limiting our understanding of what authentic leadership is and who authentic leaders are. Synthesizing what has been said about authentic leadership demonstrates why authenticity needs to be conceived of and studied differently. We offer being-in-becoming as a multi-paradigmatic umbrella which accommodates different ontological foundations of what it means to be authentic. A being-in -becoming approach recognizes that authenticity emanates from a developmental process, suggesting the study of authenticity must also be thought of processually. Studying authenticity as a developmental process holds important theoretical and practical implications as it embraces the processual nature of our dynamic, evolutionary beings.
Evaluating adherence to American College of Obstetricians and Gynecologists guidelines at the first obstetric visit
Authors: Christopher Diane , Markese Amy , Tonick Shawna , Carpenter Lauren , Harrison Margo S 
Published: September 2022

Objective: This is a prospective observational cohort study with the objective of assessing adherence to the American College of Obstetricians and Gynecologists guidelines regarding the first prenatal visit and determining what patient and provider factors are associated with high adherence in a faculty obstetric clinic at an academic medical center. Methods: The American College of Obstetricians and Gynecologists guidelines recommend addressing 72 topics early in prenatal care. A research assistant observed the first prenatal encounter and noted which topics were discussed during the visit. Patient and clinic characteristics were also collected. The primary outcome was the percentage of topics covered at each visit. After analyzing all encounters, patient encounters that scored above the median score were compared with encounters scoring below the median using bivariate comparisons with respect to patient and clinic characteristics. A multivariable Poisson regression model with robust error variance was performed on characteristics with a p value of ⩽0.2. Results: Fifty-one patient encounters met inclusion criteria and the median score for topics covered was 74%. Patients with chronic disease were more likely to have a higher percentage of topics covered (odds ratio 1.67, 95% confidence interval: 0.91–3.09). Patients who completed a prenatal questionnaire were also more likely to have a higher percentage (odds ratio 2.28, 95% confidence interval: 1.00–5.15) as well as patients who had nurse-led education integrated into their visit during (odds ratio 1.82, 95% confidence interval: 1.19–2.78). Patient satisfaction had no correlation with the number of topics covered. Conclusion: The number of topics to cover at the first prenatal visit has expanded creating challenges for patients and providers. Integration of prenatal questionnaires and nurse-led education has the potential to address gaps in antenatal care.
Clinical application of ultra-high resolution compressed sensing time-of-flight MR angiography at 7T to detect small vessel pathology
Authors: Lakhani Dhairya A , Zhou Xiangzhi , Tao Shengzhen , Westerhold Erin M , Eidelman Benjamin H , Singh Sandhu Sukhwinder Johnny , Middlebrooks Erik H 
Published: September 2022

3D time-of-flight (TOF) MR angiography (MRA) benefits from ultra-high-field MRI (≥7 T) due to improved contrast and increased signal-to-noise ratio. However, high-resolution TOF MRA at 7T usually requires longer acquisition times. In addition, relatively higher specific absorption rate (SAR) at 7T limits the choice of optimal pulse sequence parameters, especially if venous saturation is employed. Here, we illustrate the clinical application of ultra-high resolution cerebral 7T TOF MRA using compressed sensing in cases of artery of Percheron and lacunar infarcts, which showed superior resolution and exquisite details pertinent to the clinical diagnosis. The technical challenges associated with high-resolution 7T imaging were alleviated by optimization of sequence parameters and utilization of compressed sensing acceleration.
The dynamics of the general practitioner-nephrologist collaboration for the management of patients with chronic kidney disease before and after dialysis initiation: a mixed-methods study
Authors: Raffray Maxime , Vigneau Cécile , Couchoud Cécile , Laude Laetitia , Campéon Arnaud , Schweyer François-Xavier , Bayat Sahar 
Published: September 2022

Background: Effective collaboration between general practitioners (GP) and nephrologists is crucial in CKD care. We aimed to analyse GPs’ and nephrologists’ presence and involvement in CKD care and assess how they intertwine to shape patients’ trajectories. Methods: We conducted a mixed-methods study that included all patients with CKD who started dialysis in France in 2015 (the REIN registry) and a sample of nephrologists and GPs. We quantified professionals’ presence through patients’ reimbursed healthcare from the French National Health Data System, 2 years before and 1 year after dialysis start. Involvement in CKD care was derived from the nephrologists’ and GPs’ interviews. Results: Among 8856 patients included, nephrologists’ presence progressively increased from 29% to 67% of patients with a contact during the 2 years before dialysis start. However, this was partly dependent on the GPs’ referral practices. Interviews revealed that GPs initially controlled the therapeutic strategy on their own. Although unease grew with CKD’s management complexity, reducing their involvement in favour of nephrologists, GPs’ presence remained frequent throughout the pre-dialysis period. Upon dialysis start, nephrologists’ presence and involvement became total, while GPs’ greatly decreased (48% of patients with a contact at month 12 after dialysis start). Collaboration was smooth when GPs maintained contact with patients and could contribute to their care through aspects of their specialty they valued. Conclusions: This mixed-methods study shows presences and forms of involvement of GPs and nephrologists in CKD care adjusting along the course of CKD and unveils the mechanisms at play in their collaboration.
The Operating Culture of Finnish Christian Schools1
Authors: Saari Kirsti 
Published: September 2022

The main focus of the article is to describe the educational purpose of Finnish Christian schools within their operating culture. The empirical data was derived from the curricula of the schools, questionnaires and interviews. The curricula were examined for the background of the schools’ operations. The theoretical and conceptual framework of the study was built on the philosophy of Martin Buber. The research findings are integrated with the theoretical framework. The study does not emphasise the Christian values but considers them as presuppositions. The context of the questionnaires was a Christian worldview. The method of the research study was mainly content analysis interpreted according to the hermeneutical tradition emphasising interpretation. and understanding. It was concluded that educational relationship was regarded as fundamental reflecting the absolute value of each student. Communication skills were viewed as essential in building relationships including taking account of emotions. Pupils learned to understand one another's experiences by discussions and listening to the others. Individual attention and time were the keys to promoting wellbeing and personal encounter. Shared everyday life at schools was emphasised by teachers. The active role of parents was also an essential part of the school culture.
Pedagogy for Intangible Cultural Heritage in Pandemic Times: Reflections from an International Workshop during Covid-19
Authors: Chapagain Neel Kamal , Chheda Bharvi 
Published: September 2022

Intangible cultural heritage (ICH) as an articulated concept and terminology gained prominence with the adoption of UNESCO’s 2003 convention on safeguarding ICH. The convention also emphasizes capacity building as a key strategy for the safeguarding of ICH (UNESCO, n.d.-b). UNESCO, through the Global Capacity Building programme (UNESCO, n.d.-c), has already put together a network of facilitators and a series of initiatives to promote and implement these activities. Yet, there is a need for more capacity-building programmes to cater to diverse needs and audiences. During the COVID-19 pandemic restrictions, one of the many programmes offered online was that by the Centre for Heritage Management, Ahmedabad University, on ‘ICH and Sustainable Development’ with financial assistance from the International Centre for Information and Networking for Safeguarding ICH (ICHCAP) and supported by UNESCO Bangkok. Originally intended to be in person, it had to be offered online due to the uncertainties of the pandemic. However, the change of mode allowed a larger access to more participants and an extended timeline for the workshop. It also became a constructive challenge to adapt a pedagogy from a field-based into an online environment. This article reflects on such experiences and outcomes of the workshop and concludes with some thoughts on the post-COVID-19 pedagogical strategies for teaching and learning on ICH.
Establishment of the Mouse Model of Social Avoidance Induced by Female-Directed Female Aggression
Authors: Kim Jiwon , Pokharel Kritika , Sandali Michael , Kim Chung Sub 
Published: September 2022

Background Most preclinical research on the effects of stress has been done on male subjects, even though women are more prone than men to experience stress-related problems. Chronic social defeat stress (CSDS) is a rodent model of psychosocial stress. However, this model has been challenged in female mouse studies since neither male nor female resident mice attack intruder females. A female-to-female CSDS model is needed to investigate the physiological and behavioral aspects. Methods The intruders were either male or female C57BL/6J mice, whereas the residents were male or ovariectomized (OVX) female CD-1 mice. The CD-1 aggressor mice had direct physical contact with the C57BL/6J mice for 10 min before initiating sensory contact with them for 24 h. Jump escape and freezing were evaluated during the social defeat of days 1 and 12. Experimental C57BL/6J mice underwent a social interaction test after suffering social defeat for 12 days. Results We found that the number of attack bites and attack latency had a significant negative correlation during the selection of aggressors. In the single-housed OVX mice, 34% of mice met the criterion of the selection of aggressors. However, single-housed OVX mice did not show sustained aggressive behavior (eg, attack bites) through the 12-day CSDS. As a result, we did not find susceptible mice during the social interaction test. In contrast, during the selection of aggressors, 42% of OVX mice housed with partners satisfied the criterion and displayed consistently aggressive behavior. CSDS produced susceptible (50%) and resilient (50%) phenotypes during the social interaction test. Notably, male and OVX female CD-1 mice housed with partners had similar amounts of attack bites and attack rates over the 12-day CSDS. Finally, we found that chronically socially defeated male and female mice displayed different coping behaviors (eg, active vs passive) with social defeat. Conclusions Our study demonstrates that OVX CD-1 mice housed with mates exhibited territorial aggression toward female intruders, producing susceptibility and resilience to social avoidance. Additionally, socially defeated male and female mice displayed different behavioral susceptibility to social defeat.