bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical Archive of Blood Pressure and Evolution of Hypertension
Authors: Tengiz Istemihan , Fıcı Francesco , Ercan Ertugrul , Grassi Guido , Robles Nicolas Roberto , Faikoglu Gokhan 
Published: May 2022

Blood pressure is the pressure of the blood within the arteries of the circulatory system. The pulse is the feeling of the heartbeat in some arteries. Hypertension also known as high blood pressure, is the name given to a common medical condition in which the force exerted by the blood carried from the heart to the body against the walls of the arteries is high enough to cause health problems such as heart disease. Hypertension has been known since antiquity. Descriptions have been found in the Egyptian papyri, in ancient Chinese and Indian medical literature, as well as, in the work of ancient Greek physicians such as Galen and Hippocrates and Muslim scientists into Latin in Andalusia and Sicily. When we come to the 17th century, we see that blood circulation was experimentally proven by William Harvey. The important work of the 18th century, blood pressure was first recognized and first attempts were made to measure this pressure. The clinical sphygmomanometer that could measure systolic pressure over the radial artery is defined by Samuel von Basch in 1880. 20th century has witnessed changes in terminology, discovery of the measurement method that is recently used and emergence of pathogenetic definitions and by the middle of the twentieth century, checking BP by sphygmomanometer became part of the routine physical examination in hospitals and clinics. It was considered necessary to treat hypertension after the detrimental effects of high blood pressure on the body were noticed. So reserpine, hydralazine, ganglion blocking agents, peripheral adrenergic inhibitor, oral diuretics, beta blocker, ACE inhibitors, calcium channel blockers drugs such as were synthesized. While the use of some drugs is limited due to their side effects, some are still used in the treatment of hypertension today. Additionally the potential for gene therapy in hypertension is one that will be watched with interest.The search for new antihypertensive drugs are still ongoing. The potential for gene therapy in hypertension is one that will be watched with interest.
Keywords: History of blood pressure, pulse, hypertension, antihypertensive drugs
Non-Hodgkin's Lymphoma and Spondylitis in Type-2 Diabetes Mellitus: A Rare Geriatric Case Report
Authors: Pattanshetti Aishwarya , Bali Prasad N 
Published: May 2022

Purpose- Type 2 diabetes mellitus is a metabolic condition characterized by organ failure. In patients with type 2 diabetes, maintaining tight glycaemic control requires timely adjustments and changes in therapy. In children and adolescents, spondylolysis is a common cause of back pain. Spondylitis is more common in men than in women, and it is caused by a congenital defect. T-cell Non-Hodgkin lymphomas are a rare cancer of the lymphatic system. NHL are lymphoid tumours caused by chromosomal translocations, infections, immunodeficiency states, environmental causes, or persistent inflammation.
Methods- A 65 years old male patient admitted to the tertiary care hospital. Past medical history of patient includes he was suffering from lower back pain along with increased blood sugar level since1 month. Past medical history of patient was Type-2 diabetes mellitus since 3years, spondylitis since 6month along with newly detected Non-Hodgkin’s lymphoma. T-cell Non-Hodgkin lymphomas are a rare cancer of the lymphatic system. There are 9 different clinics pathologic peripheral T-cell NHLs recognized by the current WHO/EORTC classification.
Result and Conclusion- Early diagnosis is important for effective and curative therapy management. Early investigations include MRI, Chest X-ray and Ultrasonography. MRI examination of the spine is particularly helpful to diagnose and treatment of this rare disease.
Keywords- Oral Anti-Diabetic Drugs, Non-Hodgkin’s Lymphoma, Spondylitis, Diabetes mellitus, spondylolisthesis
Preliminary Phytochemical screening, In vitro antioxidant activity and acute oral toxicity study of polyherbal formulation for chronic kidney disease
Authors: MC Kamaraj , Ramakrishnan Akshaya , V Bhanu Deepthi 
Published: May 2022

Chronic Kidney Disease (CKD) is an increasing public health problem in developing countries with poor health outcomes. There is a constant demand to develop new, effective and affordable drugs for chronic kidney diseases (CKD). The Indian traditional medicinal system, Ayurveda is a valuable and alternative resource for identifying novel drugs for kidney diseases. The aim of the present study is to investigate the phytochemical screening, in vitro antioxidant activity, and in vivo acute oral toxicity study of polyherbal formulation for chronic kidney disease. All the experiments were conducted by using standard procedures. The results of the phytochemical screening revealed the presence of different types of secondary metabolites like alkaloids, phenols, saponins, flavonoids, steroids, tannins, and glycosides. The antioxidant activity of the formulation was evaluated by DPPH free radical scavenging assay. Rutin was used as a reference compound. The IC50 value of the formulation was found to be 7.39071 % and the standard rutin was 5.69024 %. The acute toxicity study was conducted in Wister albino rats. The formulation was administered as a single dose of 2000 mg/kg body weight. In this study, no visible behavioral changes and mortality was observed up to 2000 mg/kg body weight. We conclude that the polyherbal formulation did not exhibit any toxic effects on rats in terms of liver and renal functions, 15 days after administration. Taken together, these results provide scientific validation for the use of the polyherbal formulation as a potential treatment against chronic kidney disease.
Keywords: Polyherbal formulation, Ayurveda, Phytochemical screening, in vitro antioxidants, acute oral toxicity, albino rats.
Evaluation of antibacterial and antifungal activities of N-benzylthienopyrimidinone derivatives
Authors: DIEDHIOU Adama , BALDE Mamadou , NDOYE Idrissa , THIAM Mouhamadou , TIRERA Harouna , DIOP Abdoulaye , GUEYE Rokhaya Sylla , TINE Yoro , DIENG Assane , NDOYE Samba Fama , SECK Insa , SECK Matar , WELE Alassane , FALL Djibril , GRAVIER Denis , LEMBEGE Martine , HOU Géneviève , BESTEL Isabelle 
Published: May 2022

This study is part of the biological investigation of the chemical library of molecules already described by the Laboratory of Organic Chemistry and Therapeutic Chemistry of the University of Bordeaux. The main objective was to explore the contribution of a thienyl moiety attached to the pyrimidinone nucleus, in the expression of an antimicrobial activity.
The structural modifications mainly concerned the conservation or not of the benzo fragment attached to the thienyl, the saturation or not in position-1,2 of the pyrimidinone ring, the substitution on N-benzyl with more or less lipophilic units, the modification of the orientation of the thienyl fragment with, on the one hand, the compounds in which the sulfur is located near the N1 nitrogen (series of thieno[2,3-d]pyrimidin-4-ones) and on the other hand, compounds in which the sulfur is located near the ketone group (series of thieno[3,2-d]pyrimidin-4-ones).
In general, thienyl fragment with sulfur located near the ketone group and the unsaturated pyrimidinone nucleus in the 1,2-position, seem to promote a broad spectrum of antibacterial activity, with compound 9c which is active on both Gram + bacteria and Gram – bacteria studied. The same pattern was observed for antifungal activity, which is maximum with the compounds of the thieno[3,2-d]pyrimidin-4-ones series for an MIC of 31.25 μg/ml on the strains of Candida albicans and Candida kruzei studied.
Keywords: Thienopyrimidinones, antibacterial activity, antifungal activity.
Formulation and Evaluation of Doxofylline-Loaded Polymeric Micelles for Pulmonary Administration
Authors: Raysing Swati Devendra , Patil Mansi Vitthal , Avhad Pratibha Ankush 
Published: May 2022

The pulmonary administration of drugs offers advantages over administration by intravenous injection. The present research work was to prepare polymeric micelles nanomicelles containing Doxofylline as dry powder for inhalation. In order to bypass the drawbacks of predictable preparations, nanotechnology-based drug delivery systems for pulmonary administration and pulmonary targeting have been oppressed. The work was aimed towards formulating the Doxofylline loaded Soluplus nanomicelles with polymer Soluplus by film hydration technique in different ratios. The nanomicelles so prepared were characterized for its particle size, ζ-potential, XRD, SEM, drug content and drug release rate. Soluplus Doxofylline Polymeric Micelles showed mean size of 70.73nm and Zeta Potential is - 8.71. The Drug Entrapment Efficiency is 87.7% and The Drug Loading Capacity is 10%. In-Vitro study reveals the drug release is 44%. Conclusion: The Doxofylline-Soluplus Polymeric Nanomicelles could have the significant value in the treatment of Asthama and COPD.
Keywords: Polymeric Nanomicelles, Asthama, COPD, Doxofylline, Film Hydration Technique, Lyophilisation, Dry powder for Inhalation.
The Effectiveness of Prenatal Couple Gentle Yoga and Birth Ball on Maternal Mental Readiness and the length of Labor at the Depok Regional Health Center
Authors: Handayani Sri , Rasumawati Rasumawati 
Published: May 2022

There are several ways to prevent pregnancy during pregnancy when the mother and baby are in a healthy condition and the delivery process is normal, including prenatal yoga, a modification of yoga that is adapted to the condition of pregnant women by preparing pregnant women physically, mentally and spiritually for the birth process. The study was conducted at the Depok Regional Health Center which aims to determine the effect of prenatal couple gentle yoga and birth ball on the mental readiness of the mother and the duration of labor, presumably as a confounder variable, namely the mother's age, education, occupation, parity and husband's support, conducted interviews and observations on the implementation of the intervention. in pregnant women and the delivery process. The research design was quasi-experimental with a post-test control group approach, the sample was quota sampling of 35-36 weeks pregnant women as many as 30 respondents in the intervention group and 30 respondents in the control group. The analysis test was carried out by linear regression. It was found that the results of the exercise of Couple gentle yoga and birth ball were significant for the maternal mental readiness of the mother and the length of labor with a P value = 0.0001. Confounding variables are the variables of mother's age, occupation and parity, the determination coefficient R2 (R square) = 0.897, meaning that the other variable implementation of exercises.
Keywords: Prenatal couple, gentle yoga, birth ball, maternal mental readiness
Potensi electronic nose 118 untuk mendeteksi penyakit busuk pangkal batang pada kelapa sawit
Authors: MULYATNI Agustin Sri , KRESNAWATY Irma , ERIS Deden Dewantara , PANJI Tri , KIMBERLY Wita , WIDIASTUTI Happy , PRIYONO Priyono , CHOTIMAH Chotimah , TRIYANA Kuwat 
Published: May 2022

AbstractBasal stem rot (BSR) disease caused by Ganoderma sp. is a major disease in oil palm. One of the keys to successfully control BSR disease is to detect the pathogenic infections as early as possible. Early detection technique has been developed in this study was using volatile compounds sensors known as an electronic nose, specifically Electronic Nose 118. Plant samples were obtained from roots, stems, leaves, and soils of four plant categories, which were midly, moderately, and severely infected by Ganoderma, and healthy plants. The test results showed that Electronic Nose was able to record the profile of volatile organic compounds (VOC) produced by Ganoderma sp. The Linear Discriminant Analysis (LDA) results showed that the root and stem samples were differentiated in fairly high level of discrimination with values of 89.66% and 94.59% respectively, while for internal validation value were 98.18% and 89.18%. However, for leaf and soil samples, Electronic Nose 118 resulted in low discriminations. The test results show that Electronic Nose 118 can distinguish samples of roots and stems of healthy plant and Ganoderma-infected plant with a high accuracy.[Keywords: Ganoderma, linier discriminant analysis (LDA), pathogen infection, sensor, volatile organic compound] AbstrakPenyakit busuk pangkal batang (BPB) yang disebabkan oleh Ganoderma sp. merupakan penyakit utama pada kelapa sawit. Salah satu kunci keberhasilan pengendalian penyakit BPB adalah diketahuinya infeksi patogen sedini mungkin. Teknik deteksi dini yang saat ini dikembangkan dalam penelitian ini adalah menggunakan sensor senyawa volatil yang dikenal dengan electronic nose, khususnya Electronic Nose 118. Sampel tanaman diperoleh dari akar, batang, daun, dan tanah dari empat kondisi tanaman, yaitu tanaman yang terinfeksi Ganoderma ringan, sedang, berat dan tanaman sehat. Hasil pengujian menunjukkan bahwa profil senyawa organik volatil yang dihasilkan oleh infeksi Ganoderma sp. dapat ditangkap oleh Electronic Nose 118 dengan baik. Hasil analisis Linear Discriminat Analysis (LDA) menunjukkan bahwa sampel akar dan batang terbedakan dengan tingkat diskriminasi yang cukup tinggi dengan nilai secara berurutan yaitu 89,66% dan 94,59%, sedangkan untuk validasi internal masing-masing 98,18% dan 89,18%. Namun demikian, untuk sampel daun dan tanah, pengujian dengan Electronic Nose 118 menghasilkan tingkat diskriminasi yang rendah. Hasil pengujian menunjukkan Electronic Nose 118 dapat membedakan sampel akar dan batang dari tanaman sehat dan tanaman terserang Ganoderma dengan akurasi tinggi.[Kata kunci : Ganoderma, LDA, infeksi patogen, sensor, senyawa organik volatil]
Crown Reconstruction of Erosive Wear Using High-viscosity Glass Ionomer Cement: A Case Report
Authors: Menezes-Silva R , Fernandes PHM , Bueno LS , Vertuan M , Rios D , Bresciani E , Borges AFS , de Lima Navarro MF 
Published: May 2022

SUMMARY
The aim of this clinical report is to present a possible alternative treatment, with 24-month follow-up, for restoring tooth loss due to extensive erosive tooth wear. A 21-year-old male patient, complaining of intense sensitivity in the maxillary posterior teeth, and presenting severe wear on maxillary premolar and molar teeth due to gastroesophageal reflux, sought care in the university clinics. The planned treatment was to refer for medical treatment and perform restorations with the high-viscosity glass ionomer cement Equia Forte (GC Corporation, Tokyo, Japan), aiming to restore the dental anatomy and to consequently decrease the pain symptomatology. A silicone guide, obtained from a diagnostic waxing, was used during the restorative approach considering the patient’s occlusion. After all the clinical steps of the restorative technique, an occlusal adjustment of restorations was performed. During monthly recalls up to 24 months, the treatment was stable and in service. In addition, the patient reported no pain and improved chewing, leading to a better quality of life.
Adhesion to a Zirconia-reinforced Lithium Silicate Ceramic: Effects of Ceramic Surface Treatments and Resin Cements
Authors: Dalla-Nora F , Guilardi LF , Zucuni CP , Valandro LF , Rippe MP 
Published: May 2022

SUMMARY

Objective
This study had the objective to test the effect of ceramic surface treatments on the microshear bond strength (μSBS) of different resin cements to a zirconia-reinforced lithium silicate (ZLS).

Methods and Materials
ZLS blocks were sectioned, embedded in acrylic resin, and then allocated into nine groups considering two study factors: “ceramic surface treatment” (HF - hydrofluoric acid; EP - self-etching primer; TBS - tribochemical silica coating) and “resin cements” (nMDP - without MDP monomer; MDP - with MDP monomer; SA - self-adhesive). Starch tubes (n=36) were placed on the treated ceramic surface and the cement was applied. Starch tubes were removed after 24 hours of storage, and the specimens were thermocycled (5,000×; 5°C–55°C). Next, the μSBS test was performed using the wire-loop technique, and topographic and failure analyses were performed.

Results
The factors “ceramic surface treatment” and “resin cement” statistically influenced the μSBS results. Considering the surface treatment factor, the TBS produced statistically lower values when the MDP resin cement was applied, being only similar to the MDP plus EP group. For the resin cement factor, no difference was found for nMDP and SA groups, apart from the surface treatments. Failure analysis showed that the groups treated with EP had a greater number of pre-test failures. The surface treatments induced noteworthy topographic alterations when compared to control (no treatment).

Conclusion
The ZLS ceramic surface treatment with tribochemical silica coating associated with the MDP-containing resin cement resulted in lower bond strength values.
Efektivitas Teknik Evaluasi Pembelajaran Menggunakan Aplikasi QR Code Terhadap Kemampuan Berpikir Kreatif Matematis Dan Kemandirian Belajar Siswa
Authors: Astrid Fauziyah , Indrawan Rully , Kariadinata Rahayu 
Published: May 2022

Pemanfaatan informasi teknologi khususnya QR code dalam pendidikan masih kurang. Oleh karena itu peneliti ingin menggunakan QR Code sebagai tekik evaluasi pada pelajaran matematika. Selama ini teknik evaluasi yang digunakan guru adalah teknik evaluasi biasa, sementara itu siswa tampak berharap lebih banyak bantuan dari teman sebayanya dalam mengerjakan soal – soal matematika, dikarenakan juga siswa kurang kreatif dan kurang mandiri dalam mengerjakan soal – soal matematika. Dalam penelitian ini peneliti menggunakan QR Code sebagai teknik evaluasi pada materi program linear. Pernyataan masalah adalah apakah siswa yang teknik evaluasinya menggunakan aplikasi QR Code kemampuan kreatif dan kemandiriannya lebih baik daripada siswa yang teknik evaluasinya tidak menggunakan aplikasi QR Code. Jumlah siswa dikelas X jurusan Adminstrasi Perkantoran di SMK Indonesia Raya Bandung tahun pelajaran 2018/2019 adalah 34 siswa kelas eksperimen dan 34 siswa kelas control. Berdasarkan hasil penelitian dapat disimpulkan bahwa siswa yang teknik evaluasi menggunakan aplikasi QR code kemampuan berpikir kreatif dan kemandiriannya lebih baik daripada siswa yang menggunakan teknik evaluasi biasa.
Asesment Capability Level dan Maturity Level Tata Kelola TI Pada Kantor Kementerian Agama Kabupaten Pesawaran Provinsi Lampung Menggunakan Framework COBIT 2019
Authors: Herianto Herianto , Wasilah Wasilah 
Published: May 2022

Abstrak. Kantor Kementerian Agama Kabupaten Pesawaran adalah instansi pemerintahan yang menangani urusan keagamaan pada tingkat kabupaten. Pemerintah telah menetapkan program pembangunan pengembangan TI yang diatur dalam PP RI No. 95 Tahun 2018 Tentang Sistem Pemerintahan Berbasis Elektronik untuk mewujudkan good government. Berdasarkan observasi dan pemetaan terhadap faktor desain terdapat masalah security system pada software dan layanan informasi yang memiliki dampak cukup buruk serta dapat menurunkan performa kualitas TI instansi. Permasalahn tersebut perlu dilakukan asesmen menggunakan framework COBIT 2019. Asemen capability level dan maturity level tata kelola TI menggunakan domain obyektif yang memiliki nilai kepentingan > 60 dan capability target 4,00 yaitu pada domain obyektif APO11, APO 13, DSS02, dan DSS03. Nilai pencapaian capability level pada domain proses APO1101 4,00/largely, APO11.02 3,80/largely, APO11.03 3,67/largely, APO11.04 4,00/largely, APO11.05 3,00/largely, APO13.01 3,00/largely, APO13.02 2,86/largely, APO13.03 3,60/largely, DSS02.01 2,20/partialy, DSS02.02 3,33/largely, DSS02.03 2,67/largely, DSS02.04 3,33/largely, DSS02.05 2,75 /largely, DSS02.06 3,50/largely, DSS02.07 3,00/largely, DSS03.01 2,33/partialy, DSS03.02 2,33/partialy, DSS03.03 3,00/largely, DSS03.04 3,33/largely, dan DSS03.05 3,33/largely. Sedangkan pencapaian maturity level pada domain obyektif APO11 3,69/qualitative, APO13 3,15/defined, DSS02 2,96/defined, dan DSS03 2,86/defined.
The medical health venture capital network community structure, information dissemination and the cognitive proximity
Authors: Pei Xiaojie , Dang Xinghua 
Published: May 2022

Abstract
This paper studies the effect of venture capital (VC) network community structure on the dissemination of information in the medical health field of China. Using theoretical analysis and empirical test, this paper divides the community structure and information dissemination. The structural dimensions of the community have different effect and intensity on information dissemination. The cognitive proximity positively (negatively) affects community structure dimensions on information dissemination. This paper finds that the network community structure has a lag effect on information dissemination, and it finds out the types of network community structure that can promote (hinder) information dissemination. These results can promote the sustainable development of the medical health industry.
Estimating the Size of Construction Industry Expenditure for Economic Development and Sustainability in Nigeria: Autoregressive Distributed Lag (ARDL) Approach
Authors: Okoye Peter Uchenna , Ngwu Chukwuemeka , Nzeneri Oluchukwu Precious-Favour , Ohazulume Gilbert Chidi 
Published: May 2022

Abstract
The expansion of annual capital budget over the years without a corresponding increase in the volume and quality of infrastructural development in Nigeria has been attributed to those factors assumed to have great impact on the economic performance of the country. This study examined the effect of selected economic factors on the size of construction sector expenditure in Nigeria using economic data from 1981-2020. It employed econometrics statistics. The result revealed that there was a long-run co-integration among the variables with ARDL bound estimate values of F-stat. (7.40) and t-stat. (-6.56) respectively. These are higher than both the lower and upper bound critical values at 1%, 2.5%, 5% and 10% respectively. The result further revealed that exchange rate, oil prices, population, trade openness, foreign direct investment, unemployment rate, public debt and real GDP were important determinants of the size of construction sector expenditure in Nigeria. It also revealed that construction output, inflation rate, government revenue and taxation had trivial determinants due to issues relating to policy, management and execution of capital budget. The study suggested that government should make and implement apposite policies, and be diligent in allocation and management of public fund to ensure a sustainable economy through infrastructural development.
Dampak Covid-19 Terhadap Kebiasaan Bermain Gadget Pada Anak Usia Sekolah
Authors: Handoko Handoko 
Published: May 2022

The corona virus which hits Indonesia brings about a great impact on education. The learning system that is usually carried out in a face-to-face interaction changes with an online system. The online learning system which requires children to use gadgets is quite to have a big impact on children's development. The former children’s habit who were not using gadgets began to change for reasons of learning. After learning is complete, children play gadgets. The resulting impact is a decrease in interest and enthusiasm for learning. This must be controlled by parents and teachers to restore students‘ interest and enthusiasm for learning, especially of a school age students. This research was a qualitative research employing interview and observation methods. The research sample was elementary school age children who are in Seputih Banyak District, Central Lampung. The results point out that during the COVID-19 pandemic, children‘s playing habits increased. It is a common situation for school-age children to spend only a few moments studying, but spending a long time playing gadgets. A control from parents is very necessary so that school-age children can use gadgets only in line with their needs.