bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-20a: a mechanosensitive microRNA Regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by target BAMBI and SMAD6
Authors: Ai Hong , Peng Zhuli , Mai Zhihui , Xiao Feng , Liu Guanqi , Wang Yixuan , Xie Shanshan 
Published: March 2022

Abstract
Objective: MicroRNAs (miRNAs) are crucial regulators of diverse biological and pathological process. This study aimed to investigate the role of miR-20a in fluid shear stress(FSS)-mediated osteogenic differentiation.Methods: In the present study, we subject osteoblast MC3T3-E1 cells or mouse bone marrow stromal cells(BMSCs) to single bout short duration fluid shear stress(12 dyn/cm2 for 1 hour) by using a parallel plate flow system. The expression of miR-20a was quantified with miRNA array profiling and quantitative RT-PCR (qRT-PCR) during the FSS-mediated osteogenic differentiation. Bioinformatics analysis and a luciferase assay were performed to confirm potential targets of miR-20a.Results: Osteoblast-expressed miR-20a is sensitive to the mechanical environments of FSS, which is differentially upregulated During Steady FSS-mediated Osteogenic Differentiation. MiR-20a enhances FSS-induced osteoblast differentiation by activating the BMP2 signaling pathway. Both BAMBI and SMAD6 are targets of miR-20a that negatively regulate the BMP2 signaling pathway.Conclusion: MiR-20a is a novel mechano-sensitive miRNA that can enhance osteoblast differentiation in FFS mechanical environments, implying that this miRNA might be a target for bone tissue engineering and orthodontic bone remodeling for regenerative medicine applications.
The pattern and treatment outcomes for rectal cancer with concurrent locoregional recurrence and distant metastases after total mesorectal excision
Authors: Chen Yikuan , Li Yaqi , Mo Shaobo , Hu Xiang , Liu Fangqi , Cai Sanjun , Ma Xiaoji , Peng Junjie 
Published: March 2022

Abstract
Objective
To study the pattern and treatment outcome of rectal cancer (RC) with concurrent locoregional recurrence (LR) and distant metastasis (DM) after total mesorectal excision (TME) and to identify patient-, disease-, and treatment-related factors associated with differences in prognosis after concurrent LR and DM.
Methods
RC patients who were diagnosed with concurrent LR and DM after TME from May 2015 to June 2019 were included in our study. All patients received single or multiple treatment modalities under the guidance of multidisciplinary team (MDT) of colorectal cancer in Fudan University Shanghai Cancer Center.The prognostic of various clinicopathological factors for survival calculated by Kaplan-Meier curves and Cox regression analysis.
Results
A total of 74 RC patients with conurrent LR and DM after TME were eligible for analysis with median follow-up of 27 months. Median survival of patients included was 34 months and 30 patients (41%) died. 59 patients (80%) underwent comprehensive treatments. Patients with oligometastatic disease (OMD) achieved no evidence of disease (NED) status more frequently than those with multiple metastases (P = 0.003). In the univariate analysis, patients achieving NED, diagnosed with OMD and five or less peritoneal metastases tended to have longer survival after LR and DM diagnosis (P < 0.05). In the multivariate analysis, attaining NED status was the only independent factor for survival (hazard ratio (HR), 2.419; P = 0.032). Survival after concurrent LR and DM in the non-NED group was significantly shorter than in the NED group (median survival, 32 vs 46 months; HR, 2.7; P = 0.014).
Conclusion
The pattern and treatment outcome of RC with concurrent LR and DM after TME has changed with development of multiple treatment modalities. Although the prognosis is still poor, pursuing NED status through comprehensive treatments may improve the survival of RC patients with concurrent LR and DM after TME.
On the throughput of the common target area for robotic swarm strategies
Authors: Passos Yuri Tavares dos , Duquesne Xavier , Marcolino Leandro Soriano 
Published: March 2022

Abstract
A robotic swarm may encounter traffic congestion when many robots simultaneously attempt to reach the same area. For solving that efficiently, robots must execute decentralised traffic control algorithms. In this work, we propose a measure for evaluating the access efficiency of a common target area as the number of robots in the swarm rises: the common target area throughput. We also employ here the target area asymptotic throughput — that is, the throughput of a target region with a limited area as the time tends to infinity — because it is always finite as the number of robots grows, opposed to the relation arrival time at the target per number of robots that tends to infinity. Using this measure, we can analytically compare the effectiveness of different algorithms. In particular, we propose and formally evaluate three different theoretical strategies for getting to a circular target area: (i) forming parallel queues towards the target area, (ii) forming a hexagonal packing through a corridor going to the target, and (iii) making multiple curved trajectories towards the boundary of the target area. We calculate the throughput for a fixed time and the asymptotic throughput for these strategies. Additionally, we corroborate these results by simulations, showing that when a strategy has higher throughput, its arrival time per number of robots is lower. Thus, we conclude that using throughput is well suited for comparing congestion algorithms for a common target area in robotic swarms even if we do not have their closed asymptotic equation.
Comprehensive bioactivity of Pleurotus flabellatus lectin and their interruption in apoptosis inducing WNT pathway
Authors: Murugesan Arul Kumar , Sathuvan Malairaj , Javee Anand 
Published: April 2022

Abstract
Cancer is the high leading cause of cancer temporality worldwide. Treatment of cancer has always been a challenge for primary care and the development of appropriate medicine against colon and lung cancers is a major focus for budding researchers in the field. The mushroom lectin has, a few studies explored relating to the biological activity such as antibacterial, antifungal, anticancer activity and others. The mushroom lectin has attained considerable attention recently. The present study was undertaken to evaluate Pleurotus flabellatus lectin (PFL-L) induced cell death on human pathogenic fungal cells. Fungal cell viability was estimated at different intervals, moreover Aspergillus niger has the lowest cell viability (11%) compared to the others. Additionally, PFL-L was examined on human colorectal carcinoma cancer (HT29) cells and lung carcinoma cancer (A549) cells. The apoptotic changes were detected by apoptosis assay on HT29 cells and A549 cells. Further, PFL-L was demonstrated to the HT29 cells were disturbed against the presence of PFL-L at 100 µg/mL and the cell viability range is 25.90 ± 1.52%, whereas the A549 cells range is low. Then, the PFL-L initiates that DNA damage within cancer cells and the effects of cancer-related proteins were examined.
Monthly assessment of the relative abundance and development of immature stages of Culex mosquitoes (Diptera: Culicidae) of the selected breeding habitats in Niger, Nigeria
Authors: Hasber Salim , Ibrahim Kura. Shehu , Hamdan Ahmad , Israel Kayode. Olayemi , Danjuma Solomon , Abu Hassan. Ahmad , Mamman Rashidu 
Published: April 2022

Abstract
The study was conducted in gutter, swamps, and large water bodies and Culex (Diptera: Culicidae) larvae were sampled weekly from May to November 2019. Three Culex vectors identified in the areas namely, Culex quinquefasciatus, Cx. nigripalpus and Cx. salinarius. Habitats-wised showed large water habitats had the abundance of Culex followed by gutters and swamps. Based on the monthly abundance rate, the peak abundance of the immature stages was June and July and declined in November in both habitats. While the age survival rate differed significantly from one another across the months in all the habitat types. On the age distribution within the habitat types, L4 was the highest, in gutters, while in swamps, and large water habitats, L1 larvae were the most abundant, respectively. While between the habitats, gutters had a significantly higher abundance of L1, L2, L3, and L4, while swamp and larger water habitats were insignificant (p > 0.05) from one another for L1 and L4 except for the L3 immature stage that was differentiated with larger water being the most abundant. The findings imply that anthropogenic changes to the ecosystem are causing a severe hazard of Culex-Borne Diseases to public health in Niger State.
A Descriptive Retrospective Study of The Prevalence Of Antipsychotic Polypharmacy (APP) Among Schizophrenia Patients In Malaysia
Authors: Muthanna Fares M.S , Ibrahim Hamza Khaliha 
Published: March 2022

Abstract
Background
The study aimed to investigate the prevalence of APP among Malaysian patients diagnosed with schizophrenia.
Methods
A descriptive retrospective study was conducted to gather clinical and demographic information on adult individuals diagnosed with psychiatric disorders e.g schizophrenia who had been prescribed with antipsychotic drugs (Antipsychotic combination or Monotherapy) and had been admitted to Hospital Kajang in Malaysia between March 2016 and November 2016. Prevalence of antipsychotic polypharmacy (APP) is determined by determining whether the patient is given one or more antipsychotic medications or not. A descriptive analysis was carried out to evaluate the prevalence of APP among clinical and demographic variables.
Results
The study included 113 people suffering from schizophrenia. The prevalence of APP was 56.7% (n = 64). According to our results, the prevalence of APP among demographic and clinical variables were 48.4% (n = 31) among elderly patients, 61.8% (n = 40) among males, 70.3% (n = 19) among single, and 67.2% (n = 43) among unemployed schizophrenia patients.
Conclusion
According to this setting, the proportion of APP in schizophrenia patients is quite high. Being male, single and younger than 50 years of age was linked to a significant rise in APP prevalence; thus, protocols are required to recognize subgroups of psychiatric patients who are most likely benefit from novel management strategies and kidney functions.
A novel mechanism controls Li mineralization in granitic pegmatite
Authors: Zhang Xin , Zhang Hui , Tang Yong , Lv Zheng-Hang , Guan Shen-Jin , Wang Meng-Tao 
Published: April 2022

Abstract
Granitic pegmatite Li deposits account for approximately half of global Li production, while the Li mineralization mechanism remains enigmatic. Here we present Li isotope data on the albite from 8 textural zones of the well-characterized Koktokay No. 3 Li-Be-Nb-Ta-Rb-Cs mineralized pegmatite in Xinjiang, China. Our results reveal that there coexists two important processes during the internal evolution of the pegmatite: (1) fluid exsolution and (2) Li unloading. The former facilitates Li enrichment and the later results in spodumene crystallization. These “fluid transportation” processes can be indicated by a negative correlation between δ7Li value and Li content. Globally, the statistical geochemical data of Li mineralized pegmatites have also yielded a negative linear correlation between δ7Li value and Li content in both of whole rock and separated mineral samples, providing compelling evidence that “fluid transportation” is the key mechanism responsible for Li mineralization in granitic pegmatites. This finding is of great significance for Li metal deposit modeling, highlighting an urgent need to better understand the dynamic processes of magmatic-hydrothermal interaction during the crystallization of pegmatite magma.
Application of Nature-Based Nanotechnology for Enhancing Biocementation in Clay by Microbially Induced Calcium Carbonate Precipitation
Authors: Ghalandarzadeh Sara , Maghoul Pooneh , Ghalandarzadeh Abbas , Courcelles Benoit 
Published: March 2022

Abstract
Microbially induced calcium carbonate precipitation (MICP) is a nature-based soil stabilization technique, which has been developed for the past 20 years. Nevertheless, the application of the MICP method for stabilization of clays has received less attention in the literature as it is necessary to boost its effect in various ways to ensure its efficiency. Simultaneous use of the MICP method with natural nanomaterials can be a way to enhance the performance of MICP. In this study, the effect of nano-CaCO3 and nano-SiO2 on enhancing the MICP processes in a kaolinite clay is investigated. The nanomaterials and bacteria and cementation solutions were added to the host soil with different percentages. A series of unconfined compressive strength (UCS) tests was conducted to study the effect of nano-enhanced bio-cementation on soil strength after different curing times. Furthermore, the microstructure of the treated soils was investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Raman spectroscopy, chemical decomposition and X-ray diffraction (XRD) analyses. It was observed that the amount of calcium carbonate and UCS increased in all nano-bio-treated samples with curing time. SEM images of the modified samples showed that the soil texture becomes flocculated with the addition of nano-SiO2 with the MICP method and calcium carbonate was formed in the voids between the clay minerals, which increased the strength of the soil. XRD analyses and Raman spectroscopy confirmed the presence of calcium carbonate in the soil texture.
The effect of Clathrin protein addition on increasing the number of electrons in organic Dye-Sensitized Solar Cell (DSSC)
Authors: Trihutomo Prihanto , Marji Marji , Harly Muchammad , Wahyudi Bambang Adi , Radja Muhammad Bustomi 
Published: March 2022

Dye-Sensitized Solar Cell (DSSC) is a solar cell that uses dyes to convert sunlight into electricity, which has a wide absorption spectrum, is inexpensive and environmentally friendly. Visible light sensitive dyes are used in Dye-Sensitized Solar Cell (DSSC) types to generate electricity. Natural sensitive dyes that are commonly used in DSSC are chlorophyll derived from plants. Chlorophyll is a source of electrons which will be excited when exposed to light, resulting in an electric current in the DSSC. The most basic problem in Dye-Sensitized Solar Cell (DSSC) is that the number of electrons produced is still lower than that of silicon solar cells. This is due to the high recombination process of free electrons due to limited diffusion of electrons trapped at the boundary between TiO2 particles caused by less than optimal contact between particles. Clathrin is a protein that plays an important role in the formation of the vesicle layer which is responsible for the transport of molecules in cells. As a protein that plays an important role in the cell transport system, Clathrin can bind to ions in order to transport cells. This study has proven that the addition of Clathrin protein to the DSSC layer can increase the number of electrons generated in the DSSC. The method used in this study was to vary the addition of Clathrin content to TiO2, namely the Clathrin concentration of 0 %, 25 %, 50 % and 75 %. The results showed that increasing the Clathrin content would increase the electric current and the number of electrons generated by the DSSC, namely the 75 % Clathrin content with an electric current of 5,247 mA and the number of electrons was 3.28x1016
Streamflow forecasting in Tocantins river basins using machine learning
Authors: Duarte Victor Braga Rodrigues , Viola Marcelo Ribeiro , Giongo Marcos , Uliana Eduardo Morgan , de Mello Carlos Rogério 
Published: April 2022

Abstract
Understanding the behavior of the river regime in watersheds is fundamental for water resources planning and management. Empirical hydrological models are powerful tools for this purpose, with the selection of input variables as one of the main steps of the modeling. Therefore, the objectives of this study were to select the best input variables using the genetic, recursive feature elimination, and vsurf algorithms, and to evaluate the performance of the random forest, artificial neural networks, support vector regression, and M5 model tree models in forecasting daily streamflow in Sono (SRB), Manuel Alves da Natividade (MRB), and Palma (PRB) River basins. Based on several performance indexes, the best model in all basins was the M5 model tree, which showed the best performances in SRB and PRB using the variables selected by the recursive feature elimination algorithm. The good performance of the evaluated models allows them to be used to assist different demands faced by the water resources management in the studied river basins, especially the M5 model tree model using streamflow lags, average rainfall, and evapotranspiration as inputs.
Wartość własnych doświadczeń rodzinnych św. Augustyna
Authors: Ozorowski Mieczysław 
Published: April 2022

Niniejszy projekt badawczy ma na celu przedstawienie własnych doświadczeń związanych z małżeństwem i rodziną u św. Augustyna. Św. Augustyn jest jednym z największych teologów w starożytności chrześcijańskiej. Nie był on żonatym mężczyzną, ale urodził się w chrześcijańskiej rodzinie i posiadał pewne doświadczenie życia z kobietą w konkubinacie. Pozostawił również dużą ilość pism poświęconych zagadnieniom małżeńskim i rodzinnym. Nie tworzą one zwartego traktatu o małżeństwie i rodzinie. Są one odbiciem aktualnych i palących problemów, które nurtowały nie tylko św. Augustyna, ale również otaczających go ludzi. Wydaje się również, że św. Augustyn żył osobiście tymi zagadnieniami, które opisywał w swoich pismach. Problematyka małżeńska i rodzinna wynika z własnego osobistego doświadczenia a także doświadczenia bliskich mu ludzi. Poglądy Augustyna wywarły duży wpływ na postawę całego Kościoła Zachodniego. Podstawowym źródłem w tym zakresie pozostają jego „Wyznania”, które zawierają wiele informacji biograficznych. Jest to oryginalne opracowanie ukazujące źródła poglądów św. Augustyna na seksualność człowieka oraz jego relacje rodzinne.
Posiłki rodzinne jako narzędzie budujące więzi rodzinne oraz zapobiegające zaburzeniom psychicznym i społecznym dzieci w Stanach Zjednoczonych
Authors: Dańczak MSF Mateusz 
Published: April 2022

Autor podjął się opracowania tematu: posiłki rodzinne jako narzędzie budowania więzi. Z analizy literatury przedmiotu wynika, że posiłek rodzinny w historii ulegał przemianom i bardzo mocno zależał od sytuacji ekonomicznej i społecznej rodziny. W czasach najdawniejszych kobiety i dzieci, ze względu na niską pozycję społeczną bardzo rzadko mogły jeść razem z mężczyznami. Sytuacja uległa zmianie, gdy kobieta stała się opiekunką domowego ogniska, a dzieci odgrywały co raz większą rolę. W czasie II wojny światowej obraz rodziny, która wspólnie je obiad, był wykorzystywany do celów propagandowych, ale ze względu na liczbę mężczyzn przebywających na froncie, rzadko dochodził do skutku. Za „złoty okres” rodzinnych posiłków uznane zostały lata pięćdziesiąte XX wieku, w których były one powszechne.
Dzisiaj częstotliwość posiłków rodzinnych zależy od wielu czynników. Można tu wymienić zmiany w strukturze rodziny czy dużą aktywność pozaszkolną dzieci. Wyniki różnią się w zależności od badań, ale u wielu z nich zauważa się spadek częstości rodzinnych spotkań przy stole. Rodzice podobnie jak ich dzieci cenią sobie czas, który spędzają wspólnie podczas jedzenia, a jedną z głównych zalet takich spotkań jest wzmacnianie więzi między rodzicami i ich dziećmi. Nie jest to jednak jedyny pozytyw rodzinnych posiłków. Wśród nastolatków, którzy regularnie jedzą z rodzicami mnożna zauważyć mniejszą liczbę chorych na depresję i sięgających po różnego typu używki. W tej specyficznej grupie dostrzegalny jest również pozytywny wpływ na wyniki w nauce dzieci i młodzieży i problem nadwagi.
Correlation of Performance of Reinforced Concrete Buildings with Energy-Based Parameters
Authors: Sari Ali , Manuel Lance 
Published: March 2022

Background:
The intensity of ground shaking and the demand on structures during earthquakes have been generally characterized using parameters such as peak ground acceleration as well as strength-based parameters such as response spectrum ordinates (e.g., spectral acceleration), which represent the maximum amplitude of shaking for structures with specified natural period and damping values.

Methods:
It has long been recognized that to assess the demands on structures during earthquakes, one might employ an energy-based approach (as an alternative to the more common strength-based one), especially when there is an interest in assessing the damage potential of ground motions. The study focuses on the correlation between Ground Motion Parameters (GMPs) and structural damage indicators for reinforced concrete frames. The relationship between ground motion intensity and structural damage is of primary concern in seismic regions. Here, we consider GMPs that are strength-based (such as spectral acceleration, Sa) and energy-based (such as input energy-equivalent acceleration, Ai, and absorbed energy-equivalent acceleration, Aa), as defined in the study. In order to evaluate Ground Motion Parameters (GMPs) for efficiency, power-law format regression studies of damage measures (DM) on each GMP are utilized.

Results:
The general objective of this paper is to investigate if energy-based parameters can correlate well with structural damage. Thus, power-law formats in regression of damage on GMP are considered. In regression studies of this type, a lower standard deviation of the damage measure given the value of the ground motion parameter (GMP) is considered an indication of a stronger correlation between that damage measure and the corresponding ground motion parameter.

Conclusion:
These extensive regression studies are carried out for both low-rise and high-rise reinforced concrete buildings. Conclusions are discussed following these analyses.