bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Energy Consumption in Bluetooth 5 Protocol for IoT Applications using an Adaptive Model
Authors: Ferizhandi Amin Mortezaie , Oskuie Alireza Sinaiie , Zarepour Eisa , Mozayani Naser 
Published: October 2022

AbstractNowadays, the use of IoT-based approaches is expanding to the point where they have a variety of applications with various proposals such as monitoring and controlling things. Furthermore, many of these solutions were applicable to the application; there are other challenges, the most significant of which are energy consumption and covered area. Various investigations have been conducted to date in evaluating capabilities and improving the functionality of BLE from delay and throughput to reliability. Nonetheless, they have not considered managing energy consumption with interference in BLE 5. As a result, this paper proposes an adaptive model for managing energy consumption in BLE 5. We measured energy consumption in connection events using various types of output power and PHY in an experiment. Finally, by using the adaptive model in the mobility scenario in the IUST football stadium, we reduced 13.4% of energy consumption and 1% of missed events rather than criteria mode, which had an average of 5% missed events. In the other scenario, we reduced energy consumption by 18.7% while increasing missed events by 1% rather than criteria mode and an average of 3% in missed events.
Effects of Family-based Dignity Intervention and Expressive Writing on Anticipatory Grief in Family Caregivers of Patients with Cancer: A Randomized Controlled Trial
Authors: Najafi Tahereh , seyedfatemi Naeima , Kamyari Naser , Bolhari Jafar , rezaei masoud 
Published: October 2022

Abstract
Family caregivers of dying cancer patients may suffer from grief experiences and bereavement complications. Previous studies have proposed some psycho-emotional interventions for the management of these complications. However, little attention has been given to family-based dignity intervention and expressive writing. This study was conducted to examine the effects of family-based dignity intervention and expressive writing, combined and alone, on anticipatory grief in family caregivers of dying cancer patients. This was a randomized controlled trial, in which 200 family caregivers of dying cancer patients were randomly assigned to the 4 intervention groups: family-based dignity intervention (n = 50), expressive writing intervention (n = 50), combined family-based single dignity intervention and expressive writing (n = 50), and control group (n = 50). At baseline, 1 week and 2 weeks after the interventions, anticipatory grief was assessed by a 13-item anticipatory grief scale (AGS). We found a significant reducing effect of family-based dignity intervention on AGS (-8.12 ± 1.53 vs. -1.57 ± 1.52, P = 0.01) and its subscales including behavioral (-5.92 ± 0.97 vs. -2.17 ± 0.96, P = 0.04) and emotional (-2.38 ± 0.78 vs. 0.68 ± 0.77, P = 0.03) subscales compared with the control group. However, no significant effect was seen for expressive writing intervention and combined interventions of expressive writing and family-based dignity therapy. In conclusion, family-based dignity therapy may be a safe and low-cost intervention for relieving anticipatory grief among family caregivers of dying cancer patients. Additional clinical trials are needed to confirm our findings. Registration number: IRCT20210111050010N1.
A fast ceramic mixed OH-/H+ ionic conductor for low temperature fuel cells
Authors: Tao Shanwen , Zou Peimiao , Iuga Dinu , Chen Shigang , Zhang Mengfei , Han Yisong 
Published: October 2022

Abstract
OH- and H+ ionic conductors are important electrolyte materials for electrochemical devices such as fuel cells. The high cost of the best low temperature H+ ionic conductor, Nafion membrane, and the poor chemical compatibility with CO2 in air of alkaline membrane based on quaternary ammonium groups have seriously affected the large-scale application of low temperature fuel cells. Here we show the discovery of a fast ceramic mixed OH-/H+ conductor, perovskite oxide SrZr0.8Y0.2O3-δ, which exhibits a high ionic conductivity of approximately 0.01 S cm-1 at 90°C when measured in water and wet air, sufficient to be used as electrolyte for low temperature fuel cells. The ionic conductivity is stable in wet air during the measured 130 hours. The ionic conduction was also demonstrated by near ambient temperature solid oxide fuel cells (NAT-SOFCs). This opens a window on discovering new ionic conducting materials for low temperature fuel cells.
Nitrogen Atmospheric Deposition Driven by Seasonal Processes in a Brazilian Region With Agricultural Background
Authors: Pereira Jaqueline Natiele , Mantovani Vanessa Alves , de Mello Carlos Rogério , Fornaro Adalgiza , Vieira-Filho Marcelo 
Published: October 2022

Abstract
Understanding the seasonal patterns and influencing factors of nitrogen atmospheric deposition is essential to evaluate human impacts on the air quality and nitrogen biogeochemical cycle. However, evaluation of the nitrogen deposition flux, especially in South America agricultural regions, has not been fully investigated. In this paper, we quantified the atmospheric wet deposition fluxes of total dissolved nitrogen (TDN), dissolved organic nitrogen (DON) and dissolved inorganic nitrogen (DIN), in a region with agricultural and livestock predominance in the Southern Minas Gerais region, Brazil, from May 2018 to April 2019. Deposition fluxes of nitrogen species in the wet season (October – March) were on average 4.8 fold higher than dry season, which revealed significant seasonal variations driven largely by the seasonality of rainfall and agricultural operations. We also found high NO3−/NH4+ ratios (average = 8.25), with higher values in dry season (NO3−/NH4+ = 12.8) in comparison with wet season (NO3−/NH4+ = 4.48), which revealed a higher relative contribution of NOx emissions from traffic sources in dry season. We also estimated the influence of atmospheric deposition of inorganic nitrogen (N-DIN) on environmental ecosystems, being 2.01 kgNha− 1yr− 1 with potential risk of acidification and eutrophication of 30%. Therefore, attention should be paid to the role of wet atmospheric deposition of nitrogen as a source of nitrogen environmental pollution in agricultural regions.
Cross-shore changes in upwelling from
offshore wind farm development in California
Authors: Raghukumar Kaustubha , Nelson Timothy , Jacox Michael , Chartrand Christopher , Fiechter Jerome , Chang Grace , Cheung Lawrence , Roberts Jesse 
Published: October 2022

Abstract
In California offshore waters, sustained northwesterly winds have been identified as a key energy resource that could contribute substantially to California’s renewable energy goals. However, the development of large-scale offshore wind farms has the potential to reduce the wind stress at the sea surface, which could have implications on wind-driven upwelling, nutrient delivery, and ecosystem dynamics. Using atmospheric and ocean circulation models together with a hypothetical upper boundary buildout scenario of 877 turbines spread across three wind energy areas of interest, wind speed reductions in the lee of the wind energy areas of interest are found to enhance horizontal wind stress shear, leading to reduced upwelling on the inshore side of windfarms and increased upwelling on the offshore side. These changes, when expressed in terms of widely used metrics for upwelling volume transport and nutrient delivery, show that while the net upwelling in a wide coastal band changes relatively little, the spatial structure of upwelling within this coastal region can be shifted outside the bounds of natural variability.
Efficacy and safety of TNF inhibitors in the treatment of juvenile idiopathic arthritis: a systematic literature review
Authors: Horneff Gerd , Minden Kirsten , Rolland Catherine , Daly Ana C. Hernandez , Borlenghi Cecilia , Ruperto Nicolino 
Published: October 2022

Abstract
Objective: A systematic literature review was conducted to summarize efficacy and safety data from studies that evaluated tumor necrosis factor inhibitors in patients with juvenile idiopathic arthritis (JIA).
Methods: Relevant publications were identified via online searches (cutoff: March 16, 2021). After screening search results, outcome data were extracted if the treatment arm included ≥30 patients. Outcomes were described narratively, with efficacy assessed by JIA-American College of Rheumatology (ACR) response criteria and safety assessed by the incidence of serious adverse events (SAEs) per 100 patient-years (100PY).
Results: Among 87 relevant publications included in the qualitative synthesis, 19 publications described 13 clinical trials. Across the 13 trials, the percentages of patients who achieved JIA-ACR30/50/70/90 responses at Week 12 with adalimumab ranged 71–94%, 68–90%, 55–61%, and 39–42%, respectively; with etanercept (Week 12), 73–94%, 53–78%, 36–59%, and 28%; with golimumab (Week 16), 89%, 79%, 66%, and 36%; and with infliximab (Week 14), 64%, 50%, and 22% (JIA-ACR90 not reported). SAE incidence across all time points ranged 0–13.7 SAE/100PY for adalimumab, 0–20.0 SAE/100PY for etanercept, and 10.4–24.3 SAE/100PY for golimumab (1 study). SAE incidence could not be estimated from the 2 infliximab publications.
Conclusion: Tumor necrosis factor inhibitors are effective and well tolerated in the treatment of JIA, but additional evidence from head-to-head studies and over longer periods of time, especially in the context of the transition from pediatric to adult care, would be useful.
Effect of extraction pre-treatment of larch bark on the structural and electrochemical characteristics of the carbon product
Authors: Tsyganova Svetlana , Mazurova Elena , Fetisova O'lga 
Published: October 2022

AbstractThis paper presents the synthesis of carbon material from the untreated and extracted larch bark. The influence of the extracting reagents (water, ethanol, hydrogen peroxide, and sodium hydroxide) on the structural changes of ash components of the bark was revealed. It is assumed that one of the reasons for the development of the porous structure of carbon products during carbonization of the extracted bark is associated with a decrease in ash content. It was found that the carbon product obtained from washed-out water bark has the highest value of the specific surface area (401 m2/g) and the largest accumulation of electric charge.
Initial ticagrelor monotherapy strategy is effective and safe in patient with high bleeding risk after percutaneous coronary intervention: series case reports and literature review
Authors: Cui Jianguo , Wu Xu , Jin Qinhua , Yang Xia , Qian Geng , Tian Feng , Sun Zhijun 
Published: October 2022

Abstract
Objective: Short-term duration of dual antiplatelet therapy (DAPT) followed by ticagrelor monotherapy after percutaneous coronary intervention (PCI) among patients at high bleeding risk (HBR) was identified in numerous clinical trials, but the effect of ticagrelor monotherapy as an initial regimen was unknown. To explore the efficacy and safety of ticagrelor monotherapy after PCI in patient at HBR.
Patients and methods: This were case series report at single center, unblinded without control group. A total of 12 acute coronary syndrome (ACS) patients at HBR between November 2020 and December 2021 were enrolled,17 newer generation drug-eluting stents (DES),2 drug-coated balloon (DCB) and 1 bioresorbable scaffolds (BRS) were implanted. Ticagrelor monotherapy was prescribed as an initial antiplatelet strategy after PCI. Study endpoints were major adverse cardiovascular events (MACEs) and major bleeding events at 1-month to 1-year follow-up.
Results: During hospitalization and at the 1–3-month follow-up, there were no adverse clinical events, including ischemic or major bleeding events, in any of the patients. Six patients completed 1-year clinical event-free follow-up, 2 of them had well angiographic outcomes after PCI for one year.
Conclusions: Ticagrelor monotherapy as an initial antiplatelet therapy was safety and efficacy in these patients at HBR undergoing PCI. Further prospective studies and randomized clinical trials are warranted.
Resection of Bladder Tumors at the Ureteral Orifice Using a Hook Plasma Electrode: A Case Report
Authors: Wang Ziyong , Bi Ying , Wang Qilin , Bai Yu , Li RuiQian , Yang Hong , Li Jun 
Published: October 2022

Abstract
Background
The traditional surgical approach for non-muscle-invasive bladder cancer is transurethral resection of bladder tumors using annular plasma electrodes, but we have innovatively used a hook electrode and proposed a new surgical method.
Case presentation
We assessed a 31-year-old male patient diagnosed with bladder cancer whose pathological type was low-grade urothelial carcinoma. MRI examination suggested that the patient's bladder tumor was located in the right ureteral orifice, and the tumor stage was T1. Subsequently, we used a homemade hook electrode to enucleate the tumor en bloc on the basis of accurately finding a gap between the bottom of the tumor and normal tissue. Meanwhile, we exposed the complete intramural ureter from the bladder wall and finally removed it.
Conclusions
Through this case of a patient, we explored a resection method similar to "sculpting" and achieved good surgical results. The hook electrode is a surgical tool worth promoting, and using it helps us to remove tumors precisely from the bladder wall.
Association between Type of Drinking Water and Upper Gastrointestinal Cancer Incidence in the Linxian General Population
Authors: Yang Huan , Wang Jian-bing , Wang Xiao-kun , Fan Jin-hu , Qiao You-Lin 
Published: October 2022

Abstract
Background

We aims to explore the association between type of drinking water and risk of upper gastrointestinal (UGI) cancer, including esophageal cancer (EC) and gastric cancer (GC) incidence in the Linxian General Population Nutrition Intervention Trial (NIT) cohort.

Methods

This study included healthy adults aged 40 to 69 years from the NIT cohort. All subjects were enrolled in April 1986 and followed through to March 2016. Subjects who drank tap water was treated as an exposed group whereas the remainders were considered as a comparison group. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model.

Results

During the 30-year follow-up, we identified 5463 UGI cancer cases. After adjusting for age at baseline, gender, body mass index, smoking, and alcohol drinking, family history of UGI cancer, education level, nutrition intervention arms, and intakes of fruit and vegetable, the incidence rate of UGI cancer in participants who drank tap water was significantly lower than that in participants who did not drink tap water (HR = 0.88, 95%CI: 0.83–0.94). Comparable association was observed between tap water drinking and EC incidence (HR = 0.86, 95%CI: 0.79–0.94). For EC incidence, an interaction effect was observed for riboflavin/niacin supplements and type of drinking water (Pinteraction=0.03). No association was observed between type of drinking water and GC incidence.

Conclusions

Drinking tap water was associated with decreased risk of UGI cancer incidence particularly the of EC incidence. Appropriate measures should be taken to improve the quality of drinking water in high-incidence areas of EC.

Trial registration

The trial is registered with ClinicalTrials.gov (NCT00342654, 21/06/2006), and the trial name is Nutrition Intervention Trials in Linxian Follow-up Study.
The Disturbance Factor of Hoek-Brown Failure Criterion in Dam Foundations
Authors: Demirdogen Sarper , Yildirim Sefa 
Published: October 2022

Abstract
Dam engineers frequently use the Hoek-Brown failure criterion to estimate foundation parameters of highly jointed rock masses. The disturbance factor of Hoek-Brown criterion is considered to evaluate the effects of blasting and stress relief on rock masses. Defining this strength reduction parameter has been a long-running issue in current dam engineering practice. Some preliminary guidelines for determining disturbance factors for open-pit mining, tunnels, and slope applications are available in the literature. However, the disturbance factor has not been extensively evaluated in dam foundations where conventional mechanical excavation or controlled blasting techniques are used. In this paper, it is (1) investigated what the effects of disturbance might be on dam foundations and how they differ from other practices, (2) developed a comprehensive dataset to relate rock mass properties and disturbance types to disturbance factors assigned in dams, and (3) evaluated the influence of disturbance factor on dam design by performing stability analysis. Considering all findings with field observations of disturbance effects on dam foundations, a preliminary guideline is provided for dam engineers to determine an appropriate range of disturbance factors for their applications.
VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry
Authors: Bellido Daniel Delgado , Zamudio-Martínez Esteban , Fernandez-Cortes Monica , Herrera-Campos Ana Belen , Olmedo-Pelayo Joaquin , Jordan-Perez Carmen , Exposito Jose , de Álava Enrique , Amaral Ana Teresa , O´Valle Francisco , García-Díaz Angel , Oliver F. Javier 
Published: October 2022

Abstract
Vasculogenic Mimicry (VM) refers to the capacity to form blood network from aggressive cancers cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment failure. In a previous study we demonstrated that VE-Cadherin and its phosphorylation at Y658 of VE-Cadherin modulated kaiso-dependent gene expression (CCND1 and Wnt 11) by regulation of Focal Adhesion kinase (FAK). In the present study, using a proteomic approach, we have found that β-catenin/TCF-4 is associated with nuclear VE-cadherin and enhances the capacity of malignant melanoma cells to undergo VM in cooperation with VE-Cadherin; in addition, preventing the phosphorylation of Y658 of VE-cadherin upon FAK resulted in VE-Cadherin/β-catenin complex dissociation, increased β-catenin degradation while reducing TCF-4-dependent genes transcription (C-Myc and Twist-1). Uveal melanoma cells knockout for VE-Cadherin loses β-catenin expression while the rescue of VE-Cadherin (but not of the phosphorylation defective VE-Cadherin Y658F mutant) permits stabilization of β-catenin and tumor growth reduction in vivo experiments. In vivo, the combined treatment with the FAK inhibitor PF271 and the anti-angiogenic agent bevacizumab leads to a strong reduction in tumor growth respect to the single treatment. In conclusion, the aberrant expression of VE-Cadherin in metastatic melanoma cells (from both uveal and cutaneous origins), together with its permanent phosphorylation of Y658 by FAK, favors the induction of the aggressive VM phenotype through its interaction with β-catenin to VE-Cadherin and by enhancing TCF-4 genes-dependent transcription
Social determinants impeding rural Indian women from participating in longitudinal health research: An observational study
Authors: Arun Aarthi , Prabhu Manohar Prasad 
Published: October 2022

Abstract
The social determinants of health have become an increasingly crucial public health topic in recent years and refer to the non-medical factors that affect an individual’s health outcomes. Our study focuses on understanding the various social determinants of health that most affect maternal well-being. We surveyed rural Indian women to understand their reasons for not participating in a public health research study aimed to improve their maternal outcomes. We found that the most frequent reasons cited by the women were: lack of spousal support (53.2%), lack of family support (27.9%), not having enough time (17.0%), and having a migratory lifestyle (14.8%). We also found an association between the following determinants: women who had lower education levels, were primigravida, younger, or lived in joint families were more likely to cite a lack of a husband or family support. We determined through these results that a lack of social support, time, and stable housing were the most pressing determinants of health preventing the women from maximizing their health outcomes. Future research should focus on possible programs to equalize the negative effects of these social determinants to improve the healthcare access of rural women.
A facile supercritical fluid synthesis of cobalt sulfide integrated with MXene and PANI/PDOT nanocomposites as electrode material for supercapacitor applications
Authors: sabbanahalli chetana , Upadhyay Sanjay , Joshi Naveen Chandra , Kumar Niraj , Choudhary Priyvart , Sharma Nishesh , Thaku Vikas N. 
Published: October 2022

Abstract
We report the synthesis of ternary CoS/MXene/PANI and CoS/MXene/ PEDOT composites using supercritical fluid (SCF) method for the first time. These fabricated materials along with CoS/MXene was gone through electrochemical investigations using three electrode system. Enhancement in specific capacitance was observed with inclusion of PANI (407 F/g) and further enhanced with PEDOT (630 F/g) at 2 A/g. Therefore, symmetric device using coin cell technique was fabricated by taking CoS/MXene/PEDOT and CoS/MXene/PANI as electrode material. These coin cells were further be examined on the basis of CV, GCD and EIS and it was observed that the specific capacitance was enhance in CoS/MXene/PEDOT (331.1 F/g) over CoS/MXene/PANI (246 F/g) at 2 A/g. For the material, the capacitance retention was calculated to evaluate the charge storage stability and it was observed that the CoS/MXene/PEDOT (97%) is slightly higher stable than CoS/MXene/PANI (96%).
Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation
Authors: Geng Chuanying , Zhou Huixing , Wang Huijuan , Li Yanchen , Leng Yun , Zhang Zhiyao , Jian Yuan , Yang Guangzhong , Chen Wenming 
Published: October 2022

Abstract
Background
Several studies showed that lack of CD56 expression was a poor prognostic factor for patients with newly diagnosed multiple myeloma (NDMM). However, other studies were not able to confirm the prognostic value of CD56 in NDMM. This study aimed to evaluate the prognostic value of CD56 expression for patients with NDMM who received autologous stem cell transplantation (ASCT).
Methods
We retrospectively analyzed 394 patients with NDMM under 66 years old and the propensity score matching technique was used to reduce the bias between two groups.
Results
CD56 expression was observed in 265 (67.3%) patients, and 175 (44.4%) patients received ASCT. 44.9% (119/265) CD56 positive patients received ASCT; and 43.4% (56/129) CD56 negative patients received ASCT. Univariate and multivariate analyses showed that ASCT was correlated with longer OS (p < 0.001) and PFS (p < 0.001) for CD56 positive patients. ASCT may improve PFS of CD56 negative patients in univariate analysis, but it had no impact on PFS in multivariate analysis. Moreover, ASCT could not improve OS of CD56 negative patients in univariate and multivariate analysis (p > 0.05). In the propensity score matching analysis, 216 patients with CD56 expression were identified, 108 patients had received ASCT and 108 patients had no ASCT. Among 129 patients without CD56 expression, 80 patients, 40 in each group, were identified. Among 216 matched patients with CD56 expression, patients with ASCT had longer OS (87.6 vs.56.1 months, p < 0.001) and PFS (40.4 vs.27.6 months, p = 0.003). However, ASCT had no impact on OS and PFS for matched patients without CD56 expression (p > 0.05).
Conclusions
These results demonstrated that ASCT may improve OS and PFS of patients with CD56 expression and had little impact on survival of CD56 negative patients.