bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervertebral disc approach versus nerve root approach in the treatment of cervical spondylotic radiculopathy: a cohort study
Authors: Kong Shuyi , Yang Yunuo , Cai Jianfeng , Ding Xiaoyan , Wang Kaiqiang 
Published: November 2022

Abstract
Background
With the gradual development of minimally invasive surgery, the treatment of cervical spondylosis is becoming more sophisticated and diversified. However, there was no previous study on the efficacy of intervertebral disc approach and nerve root approach for cervical spondylotic radiculopathy. This trial aims to provide a basis for the clinical treatment of cervical spondylotic radiculopathy by comparing the advantages and disadvantages of the two cutting-edge surgical methods.
Methods
Collect relevant information of patients with cervical spondylotic radiculopathy in 3 hospitals and follow up on the postoperative curative effect of the two surgical methods. The improvement of pain and numbness symptoms and cervical spine function were evaluated by NRS, NDI, and Macnab scores, and the postoperative recovery time and the improvement rate of dizziness were comprehensively analyzed. After that, we analyzed the mechanism of the different curative effects of the two surgical methods and found the different characteristics of their therapeutic targets.
Results
Compared with before treatment, the NRS scores and NDI scores of the two groups of patients were significantly decreased after treatment (P<0.05). The postoperative NRS score and NDI score of the plasma group were significantly lower than those of the radiofrequency group (2 to 3, 10 to 13, P<0.01), and the therapeutic efficiency of the plasma group was higher than that of the radiofrequency group (82% to 61%, P<0.01). The improvement rate of dizziness symptoms in the plasma group was higher than that in the radiofrequency group (79% to 43%, P<0.05), however, the proportion of people in the radiofrequency group whose symptoms improved within one week after the operation was significantly higher than that in the plasma group (51% to 24%, P<0.01).
Conclusions
Both treatment options could effectively relieved the symptoms of patients with cervical spondylotic radiculopathy, but the degree of relief was different. Compared with cervical nerve radiofrequency, cervical intervertebral disc plasma decompression can better relieve upper extremity symptoms in patients with cervical spondylotic radiculopathy, promote the recovery of cervical spine function and improve cervical spondylosis-related dizziness symptoms, which may be closely related to the reduction of the pressure on the internal tissues of the cervical spine.
Therapeutic outcome and long-term naturalistic follow-up of female adolescent outpatients with AN: clinical, personality and psychopathology evolution, process indicators and outcome predictors
Authors: Amianto Federico , Arletti Luca , Vesco Serena , Davico Chiara , Vitiello Benedetto 
Published: November 2022

AbstractBackground Anorexia nervosa (AN) is a serious mental illness of growing prevalence in childhood and adolescence. Despite its severity, there are still no completely satisfactory evidence-based treatments. Follow-up studies represent the most effective attempt to enlighten treatment effectiveness, outcome predictors and process indicators. Methods 73 female participants affected with AN were assessed at intake (T0), and at 6 (T1) and 12 (T2) months after treatment into an outpatient multimodal treatment program, 19 participants were also assessed 15 years after demission (T3). Changes in diagnostic criteria were compared with the chi-square test. Clinical, personality and psychopathology evolution were tested with GLM ANOVA for repeated measures, and using t-test or Wilcoxon test as post-hoc. T0 features of dropout, stable and healed participants were compared with ANOVA. Healed and unhealed long-term follow-up groups were compared using Mann-Whitney U test. Treatment changes were correlated to each other and to initial features using multivariate regression analysis. Results the rate of complete remission after treatment (T2) was 64.4% and 73.7% in the long-term follow-up participants (T3). Twenty-two percent of participants maintained a full diagnosis after treatment (T2), and only 15.8% of the participants at follow-up (T3). BMI significantly increased at each timepoint with respect to T0. A significant decrease of persistence and increase in self-directedness were evidenced between T0 and T2. Interoceptive awareness, drive to thinness, and impulsivity significantly decreased after treatment. Parent-rated and adolescent-rated general psychopathology significantly reduced after treatment. Lower reward dependence and cooperativeness characterized the dropout group. The healed group displayed lower adolescent-rated aggressive and externalizing, and lower parent-rated delinquent behaviors. BMI, personality and psychopathology changes were related with each other and with initial features. Conclusion a 12-months outpatient multimodal treatment encompassing psychiatric, nutritional and psychological approaches is an effective approach for the treatment of mild to moderate anorexia nervosa in adolescence. Treatment not only increases BMI but also fosters personality development and changes in both eating and general psychopathology. Lower relational abilities may obstacle healing. Approaches to treatment resistance should be personalized according to these features.
Design of compact dual wideband bandpass filter based on transversal signal interaction concepts
Authors: Qian Lirong , Zhang Zeqin , Li Cuiping , Tian Yahui , Li Honglang , Wang Litian 
Published: November 2022

Abstract
In this paper, a transversal dual-band wideband bandpass filter (BPF) with two transmission paths is proposed. Two shorted coupled lines are employed as ideal 180° phase shifting structure to realize additional transmission path. Multiple transmission zeroes are obtained by transversal signal cancellation mechanism and high selectivity passbands can be achieved. By employing the classical odd-/even mode analysis method, seven modes can be excited for dual wideband construction. The fractional band width of the first wide passband can reach 107% for multiservice application. The presented transversal BPF with dual wideband is fabricated for verification. Good agreement between experimental results and simulation predictions validates the effectiveness of presented design methodology.
Endoscopic resection for local residual or recurrent cancer after definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma
Authors: Tani Yasuhiro , Ishihara Ryu , Matsuura Noriko , Okubo Yuki , Kawakami Yushi , Sakurai Hirohisa , Nakamura Takahiko , Matsueda Katsunori , Miyake Muneaki , Shichijo Satoki , Maekawa Akira , Kanesaka Takashi , Yamamoto Sachiko , Takeuchi Yoji , Higashino Koji , Uedo Noriya , Michida Tomoki 
Published: November 2022

Abstract
Background: Chemoradiotherapy (CRT) and radiotherapy (RT) are treatment options for esophageal squamous cell carcinoma (ESCC), but local residual/recurrent cancer after CRT/RT is a major problem. Endoscopic resection (ER) is an effective treatment option for local residual/recurrent cancer. To ensure the efficacy of ER, complete removal of endoscopically visible lesions with cancer-free vertical margins is desired. This study aimed to identify endoscopic parameters associated with the complete endoscopic removal of local residual/recurrent cancer.
Methods: In this single-center, retrospective study, we used a prospectively maintained database to identify esophageal lesions that were diagnosed as local residual/recurrent cancer after CRT/RT and treated by ER between January 2012 and December 2019. We evaluated the associations of endoscopic R0 resection with findings on conventional endoscopy and endoscopic ultrasonography (EUS).
Results: In total, 98 lesions (83 cases) were identified from our database. The rate of endoscopic R0 resection was higher for flat lesions (100% versus 77%, P = 0.00014). EUS was performed for 24 non-flat lesions, and endoscopic R0 resection was achieved for 94% of lesions with an uninterrupted fifth layer.
Conclusions: Flat lesions on conventional endoscopy and lesions with an uninterrupted fifth layer on EUS are good candidates for ER.
Cabotegravir – global access to long-acting pre-exposure prophylaxis for HIV
Authors: Pepperrell Toby , Cross Samuel , Hill Andrew 
Published: November 2022

Abstract
A novel injectable pre-exposure prophylaxis, cabotegravir, has greater efficacy and acceptability than oral TDF/FTC for prevention of HIV infection. Cabotegravir is currently priced at $22,200 per year, 370-times higher than the potential $60 estimated cost-effectiveness threshold for MICs. Following civil society pressure, ViiV agreed access to generic versions in 90 countries with the Medicines Patent Pool (MPP), including all African nations. However, several MICs outside Africa have rapidly growing HIV epidemics. We analysed the ViiV-MPP deal to assess population covered and Gross Domestic Product (GDP) per capita. There were 38 countries excluded from the ViiV-MPP deal despite having a GDP per Capita lower than the highest earning African country. These countries include 2.4 billion people (30% global population), with an incidence of 122 thousand (8%). For cabotegravir to have a significant impact on HIV infections, millions will need to be treated at affordable prices in a wide range of countries.
Use of thermography to assess heat tolerance in cattle breeds
Authors: Vieira Renata , Dias Eduardo A. , Stumpf Marcelo T. , Pereira Gabriel R. , Barcellos Julio O. J. , Kolling Giovani J. , McManus Concepta 
Published: November 2022

Abstract
Thermography has grown in use in recent years. It is a valuable tool for measuring animal heat tolerance under heat stress conditions since it is a non-invasive, safe and practical methodology. Physiological variables such as respiration rate and eye temperature, and environmental variables such as air temperature and wet bulb temperature were analysed in animals from nine cattle breeds (Angus, Braford, Brangus, Canchim, Charolais, Hereford, Nelore, Simmental and Santa Gertrudis) and one bubaline (Mediterranean) from the Expointer event in Rio Grande do Sul, Brazil. Positive correlations were observed between air temperature and respiration rate and eye temperature. Furthermore, the breed strongly influenced the eye temperature and respiration rate of the animals. The inflexion points in the broken line analysis indicated the environmental temperature limits at which breeds begin to change their respiration to compensate for environmental variation. Logistic regression analysis allows us to observe how each breed behaves with the temperature change. Using respiration rates and eye temperatures it was possible to identify physiological limits for comfort in different breeds of bovine.
Functional annotation of proteins for signaling network inference in non-model species
Authors: Broeck Lisa Van den , Bhosale Dinesh , Song Kuncheng , de Lima Cássio Fonseca , Ashley Michael , Zhu Tingting , Zhu Shanshuo , De Cotte Brigitte Van , Neyt Pia , Ortiz Anna , Sikes Tiffany , Aper Jonas , Lootens Peter , Locke Anna , De Smet Ive , Sozzani Rosangela 
Published: November 2022

Abstract
Molecular biology aims to understand the molecular basis of cellular responses, unravel dynamic regulatory networks, and model complex biological systems. However, these studies remain challenging in non-model species as a result of poor functional annotation of regulatory proteins, like kinases or phosphatases. To overcome this limitation, we developed a multi-layer neural network that annotates proteins by determining functionality directly from the protein sequence. We annotated the kinases and phosphatases in the non-model species, Glycine max (soybean), achieving a prediction sensitivity of up to 97%. To demonstrate the applicability, we used our functional annotations in combination with Bayesian network principles to predict signaling cascades using time series phosphoproteomics. We shed light on phosphorylation cascades in soybean seedlings upon cold treatment and identified Glyma.10G173000 (TOI5) and Glyma.19G007300 (TOT3) as predicted key temperature response regulators in soybean. Importantly, the network inference does not rely upon known upstream kinases, kinase motifs, or protein interaction data, enabling de novo identification of kinase-substrate interactions. In addition to high accuracy and strong generalization, we showed that our functional prediction neural network is scalable to other model and non-model species, including Oryza sativa (rice), Zea mays(maize), Sorghum bicolor (sorghum), and Triticum aestivum (wheat). Taking together, we demonstrated a data-driven systems biology approach for non-model species leveraging our predicted upstream kinases and phosphatases.
The association of Cardiac Valve Calcification and 1-year Mortality after Lower-extremity Amputation in Diabetic Patients: a retrospective study
Authors: Ye Weibin , Li Li , Zeng Jianfeng 
Published: November 2022

Abstract

Background:Cardiac valve calcification predisposes patients to a higher risk of adverse events. This study aimed to investigate the association between cardiac valve calcification and 1-year mortality in diabetic patients after lower-extremity amputation.Methods:Diabetic patients requiring lower-extremity amputation were retrospectively studied. Preoperative detailed anamnesis was taken. Cardiac valve calcification was assessed using echocardiography at baseline. One-year follow-up was conducted and included clinical visits, hospital record assessment, and telephone reviews to obtain the survival status of patients.Results:Ninety-three diabetic patients participated in the study. The 1-year follow-up mortality rate after amputation was 24.7%. Compared to the survival group, the prevalence of cardiac valve calcification and RCRI were higher in the mortality group. In the Cox regression analysis, cardiac valvular calcification (HR=3.427, 95% CI=1.125-10.443, P=0.030) was found to be an independent predictor of all-cause mortality after amputation. In addition, the patients with both aortic valve calcification and mitral annular calcification had a higher all-cause mortality rate (50%). Receiver operator characteristic curve analysis showed a stronger predictive ability when using a combination of calcified valve number and RCRI (AUC=0.786 95%, CI=0.676-0.896, P=0.000).Conclusion:In diabetic patients after lower-extremity amputation, cardiac valve calcification was associated with all-cause mortality during 1-year follow-up. Combination of calcified valves number and RCRI showed a stronger predictive valuefor mortality.
An Autophagy-Related Gene Signature can Better Predict Prognosis in Osteosarcoma
Authors: Yang Liang. 
Published: November 2022

Abstract
Background
Osteosarcoma (OS) is a bone malignant tumor that occurs in children and adolescents. Due to a lack of reliable prognostic biomarkers, the prognosis of OS patients is often uncertain. This study aimed to construct an autophagy-related gene signature to predict the prognosis of OS patients.
Methods
The gene expression profile data of OS and normal muscle tissue samples were downloaded separately from the Therapeutically Applied Research to Generate Effective Treatments (TARGET) and Genotype-Tissue Expression (GTEx) databases. The differentially expressed autophagy-related genes (DEARGs) in OS and normal muscle tissue samples were screened using R software, before being subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A protein-protein interaction (PPI) network was constructed and hub autophagy-related genes were screened. Finally, the screened autophagy-related genes were subjected to univariate Cox regression, Lasso Cox regression, survival analysis, and clinical correlation analysis.
Results
A total of 120 DEARGs and 10 hub autophagy-related genes were obtained. A prognostic autophagy-related gene signature consisting of 9 genes (BNIP3, MYC, BAG1, CALCOCO2, ATF4, AMBRA1, EGFR, MAPK1, and PEX) was constructed. This signature was significantly correlated to the prognosis (P < 0.0001) and distant metastasis of OS patients (P = 0.013).
Conclusion
This signature based on 9 autophagy-related genes could predict metastasis and survival in patients with OS.
Tree volume estimation for small silvopastoral systems: do we really need the height variable to obtain sufficiently accurate results?
Authors: Müller Marcelo Dias , Borges Cristiano Amancio Vieira , Resende Leonardo Oliveira , Martins Carlos Eugênio 
Published: November 2022

Abstract

The objective of this study was to evaluate and compare the performance of single and double-entry volumetric models in estimating tree volume of eucalypt trees in different silvopastoral systems in Coronel Pacheco, Minas Gerais State, Brazil. Diameter at breast height, total height, and diameter outside the bark along the stems of the sample trees were recorded. Four single-entry and five double-entry volume models were fitted to the observed data for six strata consisting of different Eucalyptus genetic material and three silvopastoral systems, and were compared to select the best alternative. Double-entry models, specifically logarithmic Spurr and logarithmic Schumacher & Hall, fitted statistically better then single-entry ones for all but one of the strata, where they were overcome by the Husch’s model. However, although the superiority of the former can have been easily verified by different and complementary statistics, we found that the volume estimates provided by the best double-entry and the best single-entry model of each stratum differed by a quantity that can be considered irrisory, from both practical and monetary points of view. In a per tree basis, the differences, in absolute values, did not surpassed 0.051 m3, or only US$ 0.25, considering a market value of US$ 4.90/m3. And even when simulating a real scenario of batch sales for each stratum, by simple extrapolation of the mean volume and considering their effective tree stand, such differences did not exceed ±0.25 m3/ha, or ±US$ 1.20/ha. These findings suggest that the smallholder farmer does not need to estimate the height of its trees; more than this, he/she can save money by not having to do a complete forest inventory and by using single-entry models such as the Husch model for estimating the wood volume of his/her plant stand. Another highlight or reinforcement of this work is that the use of the Furnival index was crucial for a reliable selection of the best models, once it allows for comparisons at the same scale of variation.
Matlab Programming on Iris Biometric Security Using Feature Extraction Process
Authors: M Elakia , P Praveena , B Prabavathi , M Astalakshmi 
Published: November 2022

Abstract
A Biometric system provides automatic identification of an individual based on a unique feature or characteristics possessed by the individual. Iris recognition is one of the important biometrics recognition system that identify people based on the iris. Among, the biometric system iris recognition is the best and most reliable and accurate. The aim is to identify a person in real time, with high efficiency and accuracy. In this paper, iris recognition algorithm is implemented via; hybrid techniques and feature extraction process by using MATLAB coding. In hybrid technique, iris recognition is implemented using histogram equalization, wavelet techniques and some of the best edge detection, feature extraction. And Extracting a shape and texture from Characterize images using the feature extraction process.
Slit-Robo expression in the leech nervous system: insights into eyespot evolution
Authors: Kwak Hee-Jin , Jimenez Brenda Irene Medina , Park Soon Cheol , Kim Jung-Hyeuk , Jeong Geon-Hwi , Jeon Mi-Jeong , Kim Sangil , Kim Jung-Woong , Weisblat David , Cho Sung-Jin 
Published: November 2022

Abstract
Background
Slit and Robo are evolutionarily conserved ligand and receptor proteins, respectively, but the number of slit and robo gene paralogs varies across recent bilaterian genomes. Previous studies indicate that this ligand-receptor complex is involved in axon guidance. Given the lack of data regarding Slit/Robo in the Lophotrochozoa compared to Ecdysozoa and Deuterostomia, the present study aims to identify and characterize the expression of Slit/Robo orthologs in leech development.
Results
We identified one slit (Hau-slit), and two robo genes (Hau-robo1 and Hau-robo2), and characterized their expression spatiotemporally during the development of the glossiphoniid leech Helobdella austinensis. Throughout segmentation and organogenesis, Hau-slit and Hau-robo1 are broadly expressed in complex and roughly complementary patterns in the ventral and dorsal midline, nerve ganglia, foregut, visceral mesoderm and/or endoderm of the crop, rectum and reproductive organs. Before yolk exhaustion, Hau-robo1 is also expressed where the pigmented eye spots will later develop, and Hau-slit is expressed in the area between these future eye spots. In contrast, Hau-robo2 expression is extremely limited, appearing first in the developing pigmented eye spots, and later in the three additional pairs of cryptic eye spots in head region that never develop pigment. Comparing the expression of robo orthologs between H. austinensis and another glossiphoniid leech, Alboglossiphonia lata allows to that robo1 and robo2 operate combinatorially to differentially specify pigmented and cryptic eyespots within the glossiphoniid leeches.
Conclusions
Our results support a conserved role in neurogenesis, midline formation and eye spot development for Slit/Robo in the Lophotrochozoa, and provide relevant data for evo-devo studies related to nervous system evolution.
Nanofibrillated lignocellulose-based superhydrophobic coating with antimicrobial performance
Authors: Ye Mengting , Wang Shengdan , Ji Xingxiang , Tian Zhongjian , Dai Lin , Si Chuanling 
Published: November 2022

Abstract
Superhydrophobic coatings have been widely developed to endue the materials with antibacterial, self-cleaning, antiseptic, and some other multi-functionalities. Fluorochemicals are the most commonly used superhydrophobic coatings, however, the released toxic substances from fluorinated polymers are a significant source of water pollution and even a threat to human health. With the increasingly great attention to the environment, it is imperative to exploit green and effective hydrophobic coatings. Here, a nanofibrillated lignocellulose-based multifunctional superhydrophobic coating (NMSC) was fabricated by using an efficient silylation process from cellulose, tetraethyl orthosilicate, and cetyl trimethoxysilane. Microscopic, chemical structural, and thermal properties analyses revealed that the NMSC has nano roughness, low surface energy, and good thermal stability. More importantly, the NMSC displayed an unprecedented hydrophobic and self-cleaning performance (water contact angle ~ 165°). The NMSC superhydrophobic coating can realize long-term effective barriers to many fluids, including strong acid (pH = 1), strong alkali (pH = 13), alcohols, alkanes, esters, and some other organic solvents. Moreover, the NMSC also showed good antibacterial properties with E. coli and S. aureus. This work not only improved the high-value application of lignocellulose but also provides a good pathway for the development of ecological and sustainable multi-functional coatings.