bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitumor immunity and therapeutic properties of marine seaweeds-derived extracts in the treatment of cancer
Authors: El-Sheekh Mostafa M. , Nassef Mohamed , Bases Eman , Shafay Shimaa El , El-shenody Rania 
Published: August 2022

AbstractMarine seaweeds are important sources of drugs with several pharmacological characteristics. The present study aims to evaluate the antitumor and antitumor immunological potentials of the extracts from the brown alga Padinapavonica and the red alga Janiarubens, inhibiting the Egyptian marine coasts. Hep-G2 cell lines were used for assessment of the antitumor efficacy of Padinapavonica and Janiarubens extracts in vitro, while Ehrlich ascites carcinoma (EAC) cells were applied to gain more antitumor immunity and antitumor insights of P.pavonica and J.rubens extracts in vivo. In vitro antitumor potentials of P.pavonica and J.rubens extracts were analyzed against human liver cancer Hep-G2 cells by MTT and trypan blue exclusion assays. In vivo antitumor immunological potentials of P.pavonica and J.rubens extracts at low, high, and prophylactic doses were analyzed by blood counting and flow cytometry in mice challenged with Ehrlich ascites carcinoma (EAC) cells. In vitro results revealed that P.pavonica and J.rubens extracts caused significant decreases in the number and viability of Hep-G2 cells in a dose-dependent manner as compared to untreated Hep-G2 cells or Cisplatin®-treated Hep-G2 cells. In vivo findings showed that P.pavonica and J.rubens extracts at low, high, and prophylactic doses significantly reduced the number and viability of EAC tumor cells accompanied by increases in EAC apoptosis compared to naïve EAC mouse. Additionally, P.pavonica and J.rubens extracts at low and prophylactic doses remarkably increased both the total WBC count and the relative numbers of lymphocytes and decreased the relative numbers of neutrophils and monocytes. Flow cytometric analysis showed that P.pavonica and J.rubens extracts at the treatment and the prophylactic doses resulted in a significant increase in the phenotypic expressions of CD4+ T, CD8+ T, and CD335 cells compared to naïve EAC mouse. Overall, both extracts P.pavonica and J.rubens possess potential antitumor and antitumor immunological effects with less toxicity, opening new approaches for further studies of the chemical and biological mechanisms behind these effects.
ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia
Authors: Li Ran , Wu Xiaolu , Xue Kai , Li Junmin 
Published: August 2022

AbstractIntegrin subunit alpha L (ITGAL) was found aberrantly expressed in multiple cancer types, suggesting its essential role in tumorigenesis. Hence, we aimed to explore its definite role in acute myeloid leukemia and emphasize its associations with immunity. Here, we found ITGAL was highly expressed in AML patients and elevated expression was associated with poor prognosis. ITGAL was associated with age and cytogenetic risk classifications, but not relevant to AML driver gene mutations. Univariate and multivariate Cox regression analyses determined ITGAL as an independent prognostic factor. The nomogram integrating ITGAL and clinicopathologic variables was constructed to predict 1-, 3- and 5-year overall survival (OS). Functional analyses revealed that ITGAL was mainly responsible for the production and metabolic process of cytokine. As for immunity, ITGAL was positively associated with MDSCs including iDCs, and macrophages in the TCGA-LAML cohort. We also found that ITGAL was positively associated with most immune checkpoint genes and cytokines. In addition, we found that ITGAL knockdown caused substantial inhibition of cell growth and significant induction of early apoptosis in AML cells. The xenograft study indicated that ITGAL knockdown prolonged the survival of recipient mice. Overall, ITGAL is an independent prognostic factor and is closely related to the number of MDSCs and cytokine production.
The resource availability hypothesis (RAH) and cross-cultural patterns: which one explains West African Cochlospermum species’ uses in Benin?
Authors: Favi Gnimansou Abraham , Dassou Gbèwonmèdéa Hospice , Djidohokpin Donald , Ouachinou Jéronime Marie-Ange Sènamie , Kpétikou Chabi Ghyslain , Gbedolo Eutiche , Anagonou Alain , Hidalgo-Triana Noelia , Adomou Aristide Cossi 
Published: August 2022

Abstract
Background
Cochlospermum tinctorium and C. planchonii are two wide edible plants of sub-Saharan countries, e.g., Benin, widely used as food, medicine, dye, handicraft, etc. Unfortunately, the uncontrolled harvest of their rootstocks exposes them to local extension risk. To enhance knowledge on the determinants of their uses in Benin, this study aimed to (i) assess the use forms, use values, abundance and perceived spatiotemporal dynamics, (ii) determine how does local abundance or cultural patterns affect the use of Cochlospermum species, and (iii) assess local harvesting modes and conservation management practices.

Methods
In total, 756 Dialog Partners through 27 ethnic groups were questioned countrywide using semi-structured interviews. Questions refer to local taxonomy, specific uses, organs sought, harvesting modes and local conservation strategies; afterward, local abundance of each species was assessed. Ethnobotanical indicators were analyzed through citation frequencies to obtain quantitative data. Comparison tests and statistical analyses were performed using R program.

Results
C. tinctorium and C. planchonii are locally well known and involved into 83 specific uses, grouped into ten categories of which medicinal use was the main. The use values of C. planchonii (0.10 ± 0.19) and C. tinctorium (0.23 ± 0.20) varied significantly between the ethnic groups, and only C. tinctorium showed index of commercially value above 75% for some ethnic groups. The current abundance, about 84 and 97 tufts.ha−1, respectively, for C. planchonii and C. tinctorium was perceived with a decline of 81.09% (C. tinctorium) and 73.7% (C. planchonii) of informants. Moreover, the Spearman’s correlation and Kruskal–Wallis tests performed revealed that the use values of C. tinctorium and C. planchonii were significantly correlated on the one hand with their local abundance and on the other hand with the investigated ethnic groups. About 42.3% of women produced the powder as principal activity, while more than 57% produced it mainly at the end of farm work. However, the conservation management was practiced by very few informants and consisted of partial harvesting of rootstocks (41.8%, only in southern Benin), and fallowing of harvesting areas (3.97%, only in northern Benin).

Conclusion
Facing the declining abundance and increasing market demand for rootstock powder of Cochlospermum species, existing local conservation strategies should be promoted and the domestication process should be initiated for sustainable management of these important wild edible plants before these important resources disappear completely in the wild.
Development of a "Scissor-Tip-Separator" for adjustment of scissor blade separation and prevention of scissor blade damage during steam sterilization
Authors: Chiannilkulchai Natthacha , Bhumisirikul Peinjit 
Published: August 2022

Abstract
Background
Reprocess reusable surgical instruments during steam sterilization; damage occurs to sharp scissor blades in close position, so steam cannot reach the blades. Surgical instruments' management requires standards to ensure patient safety and prevent harmful pathogens, especially in the COVID-19 pandemic. Although various devices can separate scissor blades, they do not prevent damage to cutting edges. To address the above problem, we developed a new scissor protector, the "Scissor-Tip-Separator," and evaluated its efficacy.

Methods
The "Scissor-Tip-Separator" design follows the steam sterilization guideline that instrument tips must be separated. The locking handles and V groove mechanism keep the scissor blades separated while preventing damage to the cutting edges. For efficacy assessment, purposive sampling was performed to select 44 Thai perioperative nurses at Ramathibodi Hospital, Bangkok, Thailand, to evaluate the "Scissor-Tip-Separators" in 450 sterile instrument containers. All participants evaluated surgical scissors placed in the "Scissor-Tip-Separators" during instrument setup, following a problem record checklist. At the end of the fifth use, participants were asked to complete the "Scissor-Tip-Separator" Effectiveness Scale, which was used to test the structural design of the "Scissor-Tip-Separator" in terms of function, usability, and safety. The Adenosine Triphosphate surface test was also used to validate the "Scissor-Tip-Separator" cleanliness. Data were collected from August 2020 to November 2020, then analyzed via descriptive statistics.

Results
The "Scissor-Tip-Separator" met the cleaning validation criteria, and in 44 uses, the physical property remained the same. The scissor shank was discovered loose from the handle before it had been unlocked (0.2–0.4%) at the 45th use. Based on participants' opinions, the overall instrument effectiveness was high in terms of function, usability, and safety.

Conclusion
The "Scissor-Tip-Separator" regulates scissor blade separation under sterilization guidelines; it prevents damage to cutting edges, thus ensuring patient safety. It protects against losses in a sterile field and can prevent hand injuries.
A pan-Zea genome map for enhancing maize improvement
Authors: Gui Songtao , Wei Wenjie , Jiang Chenglin , Luo Jingyun , Chen Lu , Wu Shenshen , Li Wenqiang , Wang Yuebin , Li Shuyan , Yang Ning , Li Qing , Fernie Alisdair R. , Yan Jianbing 
Published: August 2022

AbstractBackgroundMaize (Zea maysL.) is at the vanguard facing the upcoming breeding challenges. However, both a super pan-genome for theZeagenus and a comprehensive genetic variation map for maize breeding are still lacking.ResultsHere, we construct an approximately 6.71-Gb pan-Zeagenome that contains around 4.57-Gb non-B73 reference sequences from fragmented de novo assemblies of 721 pan-Zeaindividuals. We annotate a total of 58,944 pan-Zeagenes and find around 44.34% of them are dispensable in the pan-Zeapopulation. Moreover, 255,821 common structural variations are identified and genotyped in a maize association mapping panel. Further analyses reveal gene presence/absence variants and their potential roles during domestication of maize. Combining genetic analyses with multi-omics data, we demonstrate how structural variants are associated with complex agronomic traits.ConclusionsOur results highlight the underexplored role of the pan-Zeagenome and structural variations to further understand domestication of maize and explore their potential utilization in crop improvement.
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis: results from the Swedish EIRA study
Authors: Hedenstierna Louise , Hedström Anna Karin , Klareskog Lars , Di Giuseppe Daniela , Alfredsson Lars , Askling Johan , Ernestam Sofia , Saevarsdottir Saedis , Ljung Lotta 
Published: August 2022

Abstract
Objectives
To investigate the association between psychosocial vulnerability, defined as either low social support or low decision latitude at work, and disease remission at 3, 12, and 60 months in patients with rheumatoid arthritis (RA).

Methods
This cohort study included all patients enrolled in both the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) 1996–2015 and the Swedish Rheumatology Quality Register (SRQ, n = 2820). Information on social support and decision latitude at work at RA diagnosis were identified from the EIRA questionnaire. Indexes for levels of social support and decision latitude at work, respectively, were calculated based on the questionnaire. Low social support and low decision latitude at work, respectively, were identified by a score in the lowest quartile and compared with the three other quartiles (not low). Disease-activity parameters were retrieved from SRQ at 3, 12, and 60 months. The associations between social support or decision latitude at work, respectively, and Disease Activity Score 28 joint count with C-reactive protein (DAS28-CRP) remission were analysed using logistic regression models adjusted for age, sex, smoking habits, alcohol habits, symptom duration, and educational level.

Results
Having low social support (n = 591) was not associated with DAS28-CRP remission at 3 (OR 0.93, 95% CI 0.74–1.16), 12 (OR 0.96, 95%CI 0.75–1.23), or 60 (OR 0.89, 95%CI 0.72–1.10) months compared to not low social support (n = 2209). No association was observed for low (n = 212) versus not low (n = 635) decision latitude at work and DAS28-CRP remission at 3 (OR 0.84, 95%CI 0.54–1.31), 12 (OR 0.81, 95%CI 0.56–1.16), or 60 (OR 1.37, 95%CI 0.94–2.01) months.

Conclusion
In a country with general access to healthcare, psychosocial vulnerability does not influence the likelihood of achieving remission in early RA.
The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial
Authors: Nematollahi Shima , Pishdad Gholam Reza , Zakerkish Mehrnoosh , Namjoyan Foroogh , Ahmadi Angali Kambiz , Borazjani Fatemeh 
Published: August 2022

Abstract
Background
Type 2 Diabetes mellitus is one of the most common chronic diseases in the world and has many complications. Due to the importance of using alternative therapies in managing symptoms of this disease, the present study was designed and conducted to investigate the effect of co-supplementation of berberine and fenugreek in patients with type 2 diabetes mellitus.

Methods
A randomized controlled clinical trial was conducted on 50 patients with type 2 diabetes mellitus. Participants were randomized in the intervention group, which received 3 capsules/day of 500 mg (300 mg of berberine + 200 mg of fenugreek seed powder) or placebo for 12 weeks. Biochemical and anthropometric variables were measured at the beginning and end of the study.

Results
We observed that fasting insulin, HbA1C, and hs-CRP significantly decreased in the intervention group compared to the baseline. The mean difference in insulin resistance (-0.32 vs. 0.15), fasting blood sugar (-14.40 vs. 1.68), and fasting insulin (- 2.18 vs. 1.34) were clinically significant in comparison to the control group. Almost all domains of SF-12 scores were significantly higher in the intervention group than in the placebo group.

Conclusions
The combination of berberine and fenugreek seed can improve cardio-metabolic status in patients with diabetes and support the anti-diabetic and anti-inflammatory role of herb in the improvement of quality of life.
Efficacy of lorlatinib after alectinib-induced interstitial lung disease in a patient with anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report
Authors: Kashizaki Fumihiro , Tanaka Arihito , Sekido Yasutomo 
Published: August 2022

Abstract
Background
Anaplastic lymphoma kinase tyrosine kinase inhibitors are standard therapeutic agents prescribed for anaplastic lymphoma kinase-positive non-small cell lung cancer, and treatment with these agents has been shown to contribute to long-term survival in patients. However, there is no consensus regarding the course of treatment after the onset of anaplastic lymphoma kinase tyrosine kinase inhibitors related drug-induced interstitial lung disease.
Here, we present a case of successful lorlatinib treatment after the onset of drug-induced interstitial lung disease caused by alectinib.

Case presentation
A 57-year-old Japanese man was diagnosed with stage IVB non-small cell lung cancer by bronchoscopy, but gene mutation testing could not be performed because of the small amount of specimen. After diagnosis, first-line therapy with cisplatin/pemetrexed was initiated, but the patient developed renal dysfunction. Bronchoscopy was performed again to guide further treatment, and the non-small cell lung cancer was found to be anaplastic lymphoma kinase positive. Alectinib was started after the onset of progressive disease, but it resulted in drug-induced interstitial lung disease, necessitating alternative treatments. He subsequently received nanoparticle albumin bound paclitaxel, which was halted in view of the renal dysfunction. Thereafter, lorlatinib was administered, which was continued without drug-induced interstitial lung disease relapse.

Conclusion
Since alectinib can occasionally cause drug-induced interstitial lung disease, as in the present case, lorlatinib may be an option to continue treatment in patients without other treatment alternatives.
Grid-Based coverage path planning with NFZ avoidance for UAV using parallel self-adaptive ant colony optimization algorithm in cloud IoT
Authors: Gong Yiguang , Chen Kai , Niu Tianyu , Liu Yunping 
Published: August 2022

AbstractIn recent years, with the development of Unmanned Aerial Vehicle (UAV) and Cloud Internet-of-Things (Cloud IoT) technology, data collection using UAVs has become a new technology hotspot for many Cloud IoT applications. Due to constraints such as the limited power life, weak computing power of UAV and no-fly zones restrictions in the environment, it is necessary to use cloud server with powerful computing power in the Internet of Things to plan the path for UAV. This paper proposes a coverage path planning algorithm called Parallel Self-Adaptive Ant Colony Optimization Algorithm (PSAACO). In the proposed algorithm, we apply grid technique to map the area, adopt inversion and insertion operators to modify paths, use self-adaptive parameter setting to tune the pattern, and employ parallel computing to improve performance. This work also addresses an additional challenge of using the dynamic Floyd algorithm to avoid no-fly zones. The proposal is extensively evaluated. Some experiments show that the performance of the PSAACO algorithm is significantly improved by using parallel computing and self-adaptive parameter configuration. Especially, the algorithm has greater advantages when the areas are large or the no-fly zones are complex. Other experiments, in comparison with other algorithms and existing works, show that the path planned by PSAACO has the least energy consumption and the shortest completion time.
Telerehabilitation for upper limb disabilities: a scoping review on functions, outcomes, and evaluation methods
Authors: Moulaei Khadijeh , Sheikhtaheri Abbas , Nezhad Mansour Shahabi , Haghdoost AliAkbar , Gheysari Mohammad , Bahaadinbeigy Kambiz 
Published: August 2022

Abstract
Background
Upper limb (UL) disabilities have attracted worldwide attention due to the high economic costs of health care and the negative effects on the quality of life of patients with these disabilities. Telerehabilitation technologies are one of the most important ways to reduce rehabilitation costs and increase the quality of life of patients. Therefore, the aim of this study was to investigate the role of telerehabilitation in improving the health status of patients with upper limb disabilities.

Methods
This scoping review was conducted by searching the Web of Science, PubMed, and Scopus until July 30, 2021. We used a data extraction form with 18 fields to extract data from primary studies. The selection of articles and data extraction was made by four researchers using a data collection form based on inclusion and exclusion criteria. Disagreements were resolved through consultation with the fifth and sixth researchers.Inclusion criteria were studies published in English, studies on upper limb disability, and telerehabilitation based on any technology (synchronous telerehabilitation, asynchronous, or both). Exclusion criteria were articles that did not focus on telerehabilitation and upper limb disabilities. Also, books, book chapters, letters to the editor, and conference abstracts were also removed.

Results
A total of 458 articles were retrieved, and after removing irrelevant and duplicate articles, 29 articles were finally included in this review. Most telerehabilitation was performed for patients with stroke (65%). Among the 15 different services provided with telerehabilitation technologies, "Evaluation of exercises and also a musculoskeletal function of patients by the therapist","Recording of patients' rehabilitation exercises and sending them to the therapist” and "Prescribing new rehabilitation exercises by the therapist" were the most widely used services, respectively. Virtual reality technologies, smart wearables, and robots were used to provide telerehabilitation services. Among the 13 types of evaluation used for telerehabilitation systems, “Evaluation and measurement of upper limb function” was the most used evaluation in the studies. "Improvement in musculoskeletal functions”, "Increasing patients' interest and motivation to perform rehabilitation exercises", and "Increasing adherence to rehabilitation exercises and greater participation in treatment processes" were the most important outcomes, respectively.

Conclusion
Our findings indicate that telerehabilitation provides individuals with equitable access to rehabilitation services, improves musculoskeletal function, and empowers individuals by providing a variety of rehabilitation capabilities.
A framework from point clouds to workpieces
Authors: Shen Li-Yong , Wang Meng-Xing , Ma Hong-Yu , Feng Yi-Fei , Yuan Chun-Ming 
Published: August 2022

AbstractCombining computer-aided design and computer numerical control (CNC) with global technical connections have become interesting topics in the manufacturing industry. A framework was implemented that includes point clouds to workpieces and consists of a mesh generation from geometric data, optimal surface segmentation for CNC, and tool path planning with a certified scallop height. The latest methods were introduced into the mesh generation with implicit geometric regularization and total generalized variation. Once the mesh model was obtained, a fast and robust optimal surface segmentation method is provided by establishing a weighted graph and searching for the minimum spanning tree of the graph for extraordinary points. This method is easy to implement, and the number of segmented patches can be controlled while preserving the sharp features of the workpiece. Finally, a contour parallel tool-path with a confined scallop height is generated on each patch based on B-spline fitting. Experimental results show that the proposed framework is effective and robust.