bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of serotonin syndrome in acutely ill patients receiving linezolid and opioids concomitantly: A retrospective cohort study
Authors: Mitwally Hassan , Saad Mohamed , Alkhiyami Dania , Fahmi Amr , Mahmoud Sara , Hmoud Eman Al , Enany Rasha El , Younis Hassan , Mohammed Shaban , Rouf Palli Abdul , Thomas Binny , Hail Moza Al 
Published: March 2022

Abstract
Introduction: Linezolid is an oxazolidinone antibiotic with a reversible, non-selective monoamine oxidase inhibitory effect. Combining linezolid with serotonergic agents may increase serotonin syndrome (SS) risk. Secondary to its high tissue penetration, linezolid is recommended in patients with suspected or confirmed resistant gram-positive bacterial infections, as pneumonia, and skin-soft tissue infections, especially if vancomycin cannot be used. However, it is unclear whether co-administration of linezolid with opioids increases the risk of serotonin syndrome. Research objective: Whether combing linezolid with opioids will increase the incidence of SS in acutely ill patients. Methods: This was a retrospective observational study. All adult patients admitted to Hamad Medical Corporation facilities in Qatar and received linezolid between March 2020 and September 2020 were included in the study. The primary outcome was the prevalence of SS defined by Hunter’s criteria. SS was confirmed if the patient had spontaneous clonus; inducible clonus plus agitation or diaphoresis; ocular clonus plus agitation or diaphoresis; tremor plus hyperreflexia; or hypertonia plus fever plus ocular clonus or inducible clonus. Results: We included 106 patients, most of the patients were males (91.5%). More than half of the cohort (56.6%) received a concomitant opioid agent. Morphine and fentanyl were the most prescribed opioids (37.7% and 34%, respectively). Among patients who received opioids, only one patient (1.6%) had spontaneous clonus. However, this patient developed spontaneous clonus post cardiac arrest, which made the association with the linezolid-opioids combination doubtful. Conclusion: In this study, the incidence of SS was low in acutely ill patients who received concomitant linezolid and opioids. However, larger prospective studies are required to confirm this finding.
Comparison of granisetron and palonosetron in triplet anti-emetic prophylaxis in non-small cell lung cancer patients receiving cisplatin-based highly emetogenic chemotherapy
Authors: Araz Murat , Beypinar Ismail , Inci Fatih , Koral Lokman , Kocak Mehmet Zahid , Korkmaz Mustafa , Demirkıran Aykut , Eryilmaz Melek Karakurt , Artac Mehmet 
Published: March 2022

Abstract
Purpose: We compared the efficacy of first-generation granisetron and second-generation palonosetron in triplet anti-emetic prophylaxis in patients with non-small cell lung cancer (NSLC) receiving cisplatin-based high emetogenic chemotherapy (HEC).Methods: This prospective, multicenter, non-randomized, observational study was conducted between June 2018 and December 2021. Patients diagnosed with NSCLC who received triplet anti-emetic prophylactic treatment with aprepitant and dexamethasone plus granisetron or palonosetron before the first cycle of chemotherapy were included in the study.At the end of the first week after chemotherapy, the emesis scale was applied to the patients during the outpatientcontrol. The primary endpoint was complete response (CR) and total control (TC).Results: One hundred twenty-one patients were included in the study. Sixty-one patients were in the granisetron group and 60 patients were in the palonosetron group. CR was higher with granisetron in the acute phase (70.5% vs. 58.3%, p=0.16; respectively) and higher with palonosetron in the delayed phase (61.7% vs. 55.7%, p=0.5; respectively), although not statistically significant. The TC rates were also not significantly different between the groups (54.1% vs.57.6%, p=0.69). Conclusion: There was no significant difference between granisetron and palonosetron in both acute and delayed control of emesis in NSCLC patients receiving cisplatin-based HEC.
Finite Element Analysis of Biomechanical Effects of Proximal Femur Shortening After Intertrochanteric Fracture
Authors: Li Weilong , Dai Bo , Guo Jian , Shi Xuchao , Gu Jie , He Zhennian , Xu Yuanlin 
Published: March 2022

Abstract
Purpose
Proximal femoral shortening is common after intertrochanteric fractures treated with proximal femoral nail anti-rotation (PFNA) .We investigated the effects of biomechanical stability of the proximal femur and helical blade which on proximal femoral shortening in intertrochanteric fractures treated with PFNA using the finite element method.
Methods
Using the computed tomography data of the proximal femur of a healthy middle-aged volunteer and Mimics software. We established the proximal femoral shortening model after intertrochanteric fracture (Evans-Jensen type III) treated with PFNA. The models were divided into non-shortening, mild shortening (4mm), moderate shortening (8mm), and severe shortening (12mm) group. Abaqus were used for mechanical analysis and to obtain the overall stiffness of the different models, stress and stress nephograms of the proximal femur, fracture surface, whole femur and helical blade.
Results
In the non-shortening, mild-, moderate-, and severe-shortening groups, the overall stiffness of the proximal femur was 6491.8N/mm, 7264.8N /mm, 8168.0N /mm and 9222.8 N /mm and the maximum stress in the cancellous bone area of the proximal femur was 4.39MPa, 3.96MPa, 3.63MPa and 3.43MPa respectively. The stress on the fracture surface gradually decreased, while the stress at the end of the helical blade increased. However, the stress at the tip decreased gradually with the increase in shortening of the proximal femur.
Conclusion
With increased proximal femur shortening, fracture stability gradually increases. Intertrochanteric fractures involving the lateral wall may increase the probability of screw blade nail withdrawal and decrease the probability of proximal cutting as shortening increases.
Memory Markers In The Continuum Of The Alzheimer’s Clinical Syndrome
Authors: Parra Mario A , Calia Clara , Pattan Vivek , Sala Sergio Della 
Published: March 2022

Abstract
BACKGROUND: The individual and complementary value of the Visual Short-Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) as markers to trace the AD continuum was investigated. It was hypothesised that the VSTMBT would be an early indicator while the FCSRT would inform on imminent progression. METHODS: Healthy older adults (n=70) and patients with Mild Cognitive Impairment (MCI) (n=80) were recruited and followed up between 2012 and 2017. Participants with at least two assessments points entered the study. Using baseline and follow up assessments four groups were defined: Older adults how were healthy (HOA), with very mild cognitive but not functional impairment (eMCI), and with MCI who did and did not convert to dementia (MCI Converters and non-Converters). RESULTS: Only the VSTMBT predicted group membership in the very early stages (HOA vs eMCI). As the disease progressed, the FCSRT became a strong predictor excluding the VSTMB from the models. Their complementary value was high during the mid-prodromal stages and decreased in stages closer to dementia. DISCUSSION: The study support the notion that neuropsychological assessment for AD needs to abandon the notion of one-size-fits-all. A memory toolkit for AD needs to consider tools that are early indicators such as the VSTMBT and that suggest imminent progression such as the FSCRT.
Scientific publishing: a free-choice elective course for undergraduate Medical Students challenged by COVID-19 pandemic
Authors: Elfakharany Yara M. , Domouky Ayat M. , Mesallam Dalia I.A. , Abdel-Kareem Reham H. , El-Sokkary rehab Hosny 
Published: March 2022

Abstract
Background: Scientific publishing is a crucial key competency in the newly integrated five years’ competency based undergraduate medical program adopted in Egypt since 2018. However, writing and publishing in peer-reviewed journals can be an overwhelming duty especially with the condensation of main curriculum and the challenge of the covid-19 pandemic. The aim of this work was to describe our experience in the design and implementation of a scientific publishing elective course challenged by the COVID-19 pandemic. Method: A four weeks’ duration course was offered for the 3rd year medical students by six staff members of different specialties and experience on how to prepare a review article to be ready for submission to an academic journal. Course learning outcomes focused on appropriate structure and writing of a review article, authorship and author order in research team, selecting suitable journal for publication and writing a cover letter for the submitted article. The students worked individually & in teams in synchronized and a-synchronized session. At the end of the course student and staff feedback were taken. Results: Out of 143 students joined the course, 89.6% students felt more knowledgeable about scientific publishing and 64.8% felt confident about submitting a good review article. Chief Points of strengths mentioned by students were Competent supervisors, an authentic experience in writing and publishing, team work, and properly prepared lectures. They showed their interest in joining an advanced level. While, limited course duration and face to face sessions due to covid lockdown, unsuitable timing of course delivery within the academic year, difficulty in communication and cooperation among team members with high work load for both students and staff, were the main points of weakness reported by both students and staff. Conclusion: scientific publishing is a suitable and interesting elective course for undergraduate medical students if successfully delivered in appropriate timing and duration with frequent synchronized sessions
BK Virus Viremia and Nephropathy in Kidney Transplant Recipients: Assessment of Predictive Factors, Low Dose Tacrolimus Plus Everolimus Effects and Viral Load
Authors: YILMAZ VURAL TANER , Kisaoglu Abdullah , Dandin Ozgur , Dinc Bora , Ozturk Sefa Alperen , Demiryilmaz Ismail , Mutlu Derya , Akkaya Bahar , Aydinli Bulent , Kocak Huseyin 
Published: March 2022

Abstract
Background
BK virus viremia or nephropathy is very important for graft survival and functions in renal transplant recipients. We aimed to determine the predictive factors of BK virus viremia or nephropathy, to discuss the effect of swiching to low dose tacrolimus plus everolimus and the viral load in kidney transplant patients.
Methods
3654 kidney transplant recipients were included in the study. Firstly, the patients were divided into two groups (Group 1: BKV (-) (n = 3525, 96.5%), Group 2: BKV viremia (+) (n = 129, viremia 3.5%, nephropathy 1%) were evaluated. Secondly, patients with BKV viremia / BKPyVAN were divided into two groups according to immunosuppressive changes (Group 2a: swiching to low dose tacrolimus plus everolimus (n = 54, 41.9%), Group 2b: swiching to other immunosuppressive protocols (n = 75, 58.1%) were evaluated. Thirdly, the cut-off value of the viral load amount (≥ 104 and < 104) was discussed.
Results
History of rejection, elderly recipient, cadaveric transplantation, use of anti-thymocyte globulin, tacrolimus and CMV viremia are predictive factors for BKV development. It was shown that the rate of viremia/nephropathy was highest in tacrolimus plus mycophenolic acid protocols, The use of low dose Tacrolimus plus Everolimus as an exchange protocol after BKV viremia or BKPyVAN had a positive effect on the outcomes, a viral load ≥ 104 was shown to be a significant cut-off value in terms of nephropathy development and graft survival.
Conclusion
BK virus development in kidney transplant recipients is multifactorial and it was thought that preventive measures may be more important than treatment.
Occurrence of Naegleria fowleri and faecal indicators in sediments from Lake Pontchartrain, Louisiana
Authors: A. Shahin Shalina , H. Alarcon Joshua , Brosky Hanna N. , Lamori Jennifer G. , Dada Ayokunle C. , Xue Jia , Gyawali Pradip , P. Sherchan Samendra 
Published: March 2022

Abstract
The occurrence of amoeba, Naegleria fowleri, in sediment samples from Lake Pontchartrain in Louisiana was investigated. This amoeba is pathogenic and can cause primary amoebic meningoencephalitis. In this study, quantitative polymerase chain reaction methods were used to test for the prevalence of Naegleria fowleri, HF183, and E. coli. N. fowleri was detected in 51.25% of our sediment samples. Illumina sequencing of sediment samples revealed ten different phyla, with Cyanobacteria being the most predominant at sites that generally presented with the highest median N. fowleri concentrations. N. fowleri was however strongly negatively correlated with HF183 (r = −0.859, p &lt; 0.001). Whenever sediment E. coli concentrations were below 1.54 Log GC/g, there was only a 37.5% chance that N. fowleri would be detected in the same sample. When sediment E. coli concentrations exceeded 2.77 Log GC/g, the chances of detecting N. fowleri in the same sample increased to 90%, potentially suggesting predatory activity by the amoeba. The effect of temperature was observed to be different in relation to observed N. fowleri concentrations and detection rates. Although sediment samples collected during periods of higher temperatures had significantly lower mean N. fowleri concentrations (2.7 Log GC/g) compared to those collected at lower temperatures (3.7 Log GC/g, t(39) = 4.167, p &lt; 0.001), higher N. fowleri detection rates in the overall samples were observed at higher temperatures (&gt;19.1 °C) than at lower temperatures (&lt;19.1 °C).
Effective degradation of 1,2-dichloroethane in calcium peroxide activated by Fe(III): performance and mechanisms
Authors: Lu Zhanpeng , Zeng Guilu , Zhou Zhengyuan , Liu Yulong , Wang Peng , Sheng Xianxian , Dong Jiaqi , Idress Ayesha , Sui Qian , Lyu Shuguang 
Published: March 2022

Abstract
As a kind of refractory chlorinated hydrocarbon, 1,2-dichloroethane (1,2-DCA) has been frequently detected in contaminated groundwater, and it is hard for common technology to degrade it due to its stability. Moreover, the existence of 1,2-DCA can do harm to human organs. Hence, it is urgent to develop an effective technology for the remediation of 1,2-DCA-contaminated groundwater. In this study, a calcium peroxide (CaO2) system activated by Fe(III) was applied to the degradation of 1,2-DCA and 83.3% of 1,2-DCA could be effectively removed within 3 h when the molar ratio of CaO2/Fe(III)/1,2-DCA was 30/120/1. The results of probe experiments, electron paramagnetic resonance (EPR) detection, and scavenging tests demonstrated that both HO• and O2−• were the key factors for 1,2-DCA degradation. The released amount of Cl− (84.1%) revealed that most of the chlorine in 1,2-DCA could be dechlorinated. GC-MS was applied for the detection of intermediates during 1,2-DCA degradation and the possible degradation pathway was proposed that 1,2-DCA was first reduced to vinyl chloride (VC) and then oxidized to CO2 and H2O. Finally, 73.4% removal of 1,2-DCA could be achieved in actual groundwater when the molar ratio of CaO2/Fe(III)/1,2-DCA was 100/400/1, demonstrating that the CaO2/Fe(III) system has a remarkable prospect in 1,2-DCA-contaminated groundwater remediation.
MIR17HG: A Cancerogenic Long-Noncoding RNA in Different Cancers
Authors: Tan Fangshun , Chen Jinlan , Du Zhuoying , Zhao Fangnan , Liu Yuling , Zhang Qi , Yuan Chengfu 
Published: March 2022

Abstract:
LncRNA MIR17HG, located at chromosome 13q31, plays an inevitable role in promoting tumor
progressions, such as tumorigenesis, proliferation, and metastasis. Besides, lncRNA MIR17HG is rare due to its
open reading frame (ORF), which can be translated to produce protein. By systematically retrieval, we summarized
that MIR17HG is an emerging lncRNA that exhibits carcinogenically in osteosarcoma (OS), glioma, cervical
squamous cell carcinoma (CSCC), colorectal cancer (CRC), gastric cancer (GC), atypical teratoid
rhabdoid tumors (ATRT). Furthermore, a high expression level of MIR17HG protein is also linked with meningioma.
Additionally, MIR17HG polymorphisms in glioma, CRC, liver cancer (LC), breast cancer (BC), head
and neck squamous cell carcinoma (HNSCC), and multiple myeloma (MM) also have a large influence on cancer
susceptibility, prognosis, and so on. Collectively, long non-coding RNA MIR17HG’s tumor-stimulative role
could be a promising therapeutic target. Besides, by investigating patients’ MIR17HG single-nucleotide polymorphisms
(SNPs), clinicians could also personalize the productive interventions in gene therapy or predict the
diagnosis/prognosis precisely.
Factors Influencing Adherence to Antipsychotic Medications in Women with Delusional
Disorder: A Narrative Review
Authors: González-Rodríguez Alexandre , Monreal José A. , V. Seeman Mary 
Published: March 2022

Background:
Adherence to medication regimens is of great importance in psychiatry because drugs
sometimes need to be taken for long durations in order to maintain health and function.

Objective:
This study aimed to review influences on adherence to antipsychotic medications, the treatment of
choice for the delusional disorder (DD), and to focus on adherence in women with DD.

Method:
This is a non-systematic narrative review of papers published since 2000 using PubMed and Google
Scholar, focusing on women with DD and medication adherence.

Results:
Several factors have been identified as exerting influence on adherence in women with persistent delusional
symptoms who are treated with antipsychotics. Personality features, intensity of delusion, perception of
adverse effects, and cognitive impairment are patient factors. Clinical time spent with the patient, clarity of
communication, and regular drug monitoring are responsibilities of the health provider. Factors that neither patient
nor clinician can control are the social determinants of health, such as poverty, easy access to healthcare,
and cultural variables.

Conclusions:
There has been little investigation of factors that influence adherence in the target population, e.g.,
women with DD. Preliminary results of this literature search indicate that solutions from outside the field of DD
may apply to this population. Overall, a solid therapeutic alliance appears to be the best hedge against nonadherence.
Production of Effective Phyto-antimicrobials via Metabolic Engineering
Strategies
Authors: Sharma Abhishek , Mistry Vyoma , Kumar Vinay , Tiwari Pragya 
Published: March 2022

Abstract:
The emerging outbreak of infectious diseases poses a challenge and threatens human sur-vival. The indiscriminate use and drying pipelines of antibiotic arsenals have led to the alarming rise of drug-resistant pathogens, projecting a serious concern. The rising antimicrobial resistance and redundancy of antibiotic discovery platforms (ADPs) have highlighted the growing concern to discover new antibiotics, necessitating exploring natural products as effective alternatives to counter drug resistance. Recently, plants have been extensively investigated in search of the “phyto-therapeutics”, attributed to their potential efficacy and tackling the majority of the drug-resistant mechanisms, including biofilms, efflux pumps, cell communication, and membrane proteins. How-ever, major challenges in geographical fluctuations, low plant concentration, and over-harvestation of natural resources restrict availability and complete utilization of phyto-therapeutics as antimicro-bials. Recent advances in scientific interventions have been instrumental in producing novel antimi-crobials via metabolic engineering approaches in plant systems. The progress in plant genome edit-ing, pathway reconstitution, and expression has defined new paradigms in the successful production of antimicrobials in the post-antibiotic era. The thematic review discusses the existing and emerging significance of phytotherapeutics in tackling antimicrobial resistance and employing metabolic en-gineering approaches. The prevailing scenario of antimicrobial resistance and the mechanisms, the traditional and modern drug-discovery approaches in addressing antimicrobial resistance, emphasiz-ing advances in metabolic engineering approaches for antimicrobial production, and the plausible solutions for tackling drug-resistant pathogens, forms the key theme of the article.
The Immune System as a Therapeutic Target for Old and New Drugs in
Parkinson’s Disease
Authors: Comi Cristoforo , Magistrelli Luca , Contaldi Elena 
Published: March 2022

Abstract:
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by loss of dopaminergic neurons and intraneuronal accumulation of protein aggregates. The exact mechanisms leading to neuronal death in PD are not fully understood, but several different molecular pathways are involved, leading to the concept that molecular subtypes may coexist in the nosological spectrum of PD. To this respect, immune system activation, both in the periphery and inside the central nervous system, was detected as a common trait of several pathogenic pathways of PD. The current working hypothesis implies that immune cells shift towards a proinflammatory phenotype and trigger the production of neurotoxic cytokines, ultimately contributing to neurodegeneration. While it is very important to understand how commonly used antiparkinson drugs interact with such changes, the search for treatments which may directly or indirectly modulate immune function is a great opportunity for disease modification.
COVID-19: RELASI SOSIAL SISWA DI BANTEN PADA PEMBELAJARAN JARAK JAUH (PJJ)
Authors: Yusuf Dede , Setiawan Rizki 
Published: March 2022

Dampak pandemi covid-19 pada sektor pendidikan ialah pelaksanaan pembelajaran jarak jauh secara daring. Hal itu mereduksi sistem pendidikan dari berbagai aspek termasuk dimensi sosial. Aktivitas sosial yang biasa terjadi di sekolah tidak memungkinkan dilakukan sehingga terjadi hambatan terhadap proses sosial secara langsung antar siswa. Oleh karena itu, Tujuan penelitian ini adalah untuk menggambarkan bagaimana relasi sosial siswa SMA lokal Banten dalam situasi Pembelajaran Jarak Jauh (PJJ) di tengah pandemi covid-19. Penelitian ini menggunakan metode survei. Hasil penelitian yang diperoleh yaitu: kuantitas interaksi langsung tatap muka bersifat jarang dan tidak sukarela. Interaksi tidak langsung melalui media teknologi bersifat intens dan terjalin keakraban pada pola interaksi tidak langsung secara online.
Efektivitas model scientific based learning pada peningkatan prestasi psikomotor siswa
Authors: Rochmah Evy Nur 
Published: March 2022

Tujuan penelitian ini adalah: untuk menguji keefektifan model scientific based learning pada peningkatan prestasi psikomotor siswa. Jenis penelitian ini yaitu menggunakan pre-exsperimental design one-group pretest-posttest design. Instrumen penelitian yang digunakan terdiri dari lembar observasi pengelolaan pembelajaran, lembar observasi kegiatan siswa, dan lembar tes. Subjek penelitian adalah siswa SD kelas II di Kecamatan Mlati yang tersebar di tiga sekolah. Responden dalam penelitian ini sebanyak 101 orang. Hasil uji keefektifan menunjukkan bahwa model scientific based learning dalam peningkatan prestasi psikomotor siswa SD kelas II memenuhi kriteria keefektifan berdasarkan hasil observasi kegiatan siswa, pengelolaan guru, pretest dan posttest. Pada uji keefektifan yang dilakukan, menunjukkan ada peningkatan skor rata-rata pada aspek psikomotor pada uji coba terbatas sebesar 20 poin. Pada uji coba lapangan menunjukkan peningkatan skor pada aspek psikomotor sebesar 25,3 poin. Pada uji coba operasional menunjukkan peningkatan skor pada aspek psikomotor sebesar 32,1 poin dengan skor maksimal 100 poin. Dari hasil uji keefektifan tersebut dapat disimpulkan bahwa model scientific based learning efektif digunakan pada peningkatan prestasi psikomotor siswa.Kata kunci: model scientific, psikomotor