bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microporous‐Ceria‐Wrapped Gold Nanoparticles for Conductometric and SERS Dual Monitoring of Hazardous Gases at Room Temperature
Authors: Bao Haoming , Guo Yujing , Zhang Tao , Fu Hao , Zhu Shuyi , Zhou Le , Zhang Hongwen , Li Yue , Cai Weiping 
Published: February 2022

AbstractThis work proposes a novel and simple synthesis method for microporous‐ceria‐wrapped gold (Au@mp‐CeO2) nanoparticles (NPs) based on linker molecule‐induced stacking of ultrafine CeO2 particles (or beads) on the surface of pre‐prepared gold NPs. The resulting NPs have a uniform size and microporous CeO2 shells with a mean thickness of 28 nm and porosity of 42%. The shell is highly tunable from about 4 to 30 nm thick. This method is universal and suitable for other metal@mp‐oxide nanoarchitectures (such as Au@mp‐CuO NPs, Au@mp‐Cr2O3 NPs, Ag@mp‐CeO2 NPs, and Ag@mp‐CeO2 nanowires) simply via changing the pre‐prepared metal cores or shell precursors. Most significantly, the as‐prepared Au@mp‐CeO2 NPs can be used for accurate monitoring of toluene vapor (10 ppm level) at room temperature based on their conductometric and surface‐enhanced Raman spectroscopy (SERS) dual response. Moreover, these NPs can be also used for other hazardous gases, such as chlorobenzene, hydrogen sulfide, and 1‐dodecanethiol. This excellent performance benefits from the micropore‐enhanced interaction between CeO2 and gas molecules. This work not only provides new and controllable preparation for metal@mp‐oxide nanoarchitectures, but also demonstrates the great potential applications of these materials in real‐time and identifiable monitoring of hazardous gases.
Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor gene
Authors: Pangilinan Faith , Watkins David , Bernard David , Chen Yue , Dong Ningzheng , Wu Qingyu , Ozel‐Abaan Hatice , Kaur Manjit , Caggana Michele , Morrissey Mark , Browne Marilyn L. , Mills James L. , Van Ryzin Carol , Shchelochkov Oleg , Sloan Jennifer , Venditti Charles P. , Sarafoglou Kyriakie , Rosenblatt David S. , Kay Denise M. , Brody Lawrence C. 
Published: February 2022

AbstractThe biological and clinical significance of the p.E88del variant in the transcobalamin receptor, CD320, is unknown. This allele is annotated in ClinVar as likely benign, pathogenic, and of uncertain significance. To determine functional consequence and clinical relevance of this allele, we employed cell culture and genetic association studies. Fibroblasts from 16 CD320 p.E88del homozygotes exhibited reduced binding and uptake of cobalamin. Complete ascertainment of newborns with transiently elevated C3 (propionylcarnitine) in New York State demonstrated that homozygosity for CD320 p.E88del was over‐represented (7/348, p < 6 × 10−5). Using population data, we estimate that ~85% of the p.E88del homozygotes born in the same period did not have elevated C3, suggesting that cobalamin metabolism in the majority of these infants with this genotype is unaffected. Clinical follow‐up of 4/9 homozygous individuals uncovered neuropsychological findings, mostly in speech and language development. None of these nine individuals exhibited perturbation of cobalamin metabolism beyond the newborn stage even during periods of acute illness. Newborns homozygous for this allele in the absence of other factors are at low risk of requiring clinical intervention, although more studies are required to clarify the natural history of various CD320 variants across patient populations.
Drastic Events and Gradual Change Define the Structure of an Active Copper‐Zinc‐Alumina Catalyst for Methanol Synthesis
Authors: Beck Arik , Newton Mark A. , Zabilskiy Maxim , Rzepka Przemyslaw , Willinger Marc G. , van Bokhoven Jeroen A. 
Published: February 2022

AbstractThe copper‐zinc‐alumina (CZA) catalyst is one of the most important catalysts. Nevertheless, understanding of the complex CZA structure is still limited and hampers further optimization. Critical to the production of a highly active and stable catalyst are optimal start‐up procedures in hydrogen. Here, by employing operando X‐ray absorption spectroscopy and X‐ray diffraction, we follow how the industrial CZA precursor evolves into the working catalyst. Two major events in the activation drastically alter the copper‐ and zinc‐containing components in the CZA catalyst and define the final working catalyst structure: the reduction of the starting copper(II) oxide, and the ripening and re‐oxidation of zinc oxide upon the switch to catalytic conditions. These drastic events are also accompanied by other gradual, structural changes. Understanding what happens during these events is key to develop tailored start‐up protocols that are aimed at maximal longevity and activity of the catalysts.
Straightforward fabrication of robust and healable superhydrophobic steel mesh based on polydimethylsiloxane
Authors: Wang Qing , Xie Dong , Chen Junjia , Luo Jie , Chen Guangxue , Yu Mingguang 
Published: February 2022

AbstractA straightforward and scalable strategy was presented for the fabrication of superhydrophobic stainless steel mesh (SSM) by depositing with polydimethylsiloxane (PDMS) to perform the hydrophobic effect. After the thermal processing with a flame for seconds, the PDMS coated steel mesh demonstrated excellent integration of superhydrophobic/superoleophilic properties. Besides, the resultant SSM showed efficient separation ability of water‐in‐oil emulsion. Furthermore, the surfaces also exhibited excellent tolerance to various chemical, UV irradiated and strongly friction‐resistant against sandpaper (50 g of force for 1000 cm). More strikingly, the damaged surfaces losing its superhydrophobicity can be simply healed by reapplying flame heat to the worn area. This straightforward and healable synthetic strategy for the manufacture of superhydrophobic SSM offers potential applications in large‐scale oil/water separation.
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis
Authors: Suppiah Ravi , Robson Joanna C. , Grayson Peter C. , Ponte Cristina , Craven Anthea , Khalid Sara , Judge Andrew , Hutchings Andrew , Merkel Peter A. , Luqmani Raashid A. , Watts Richard A. ,   for the DCVAS Study Group
Published: February 2022

ObjectiveTo develop and validate classification criteria for microscopic polyangiitis (MPA).MethodsPatients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate items using consensus methodology, 2) prospective collection of candidate items present at the time of diagnosis, 3) data‐driven reduction of the number of candidate items, 4) expert panel review of cases to define the reference diagnosis, and 5) derivation of a points‐based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators.ResultsThe development set for MPA consisted of 149 cases of MPA and 408 comparators. The validation set consisted of an additional 142 cases of MPA and 414 comparators. From 91 candidate items, regression analysis identified 10 items for MPA, 6 of which were retained. The final criteria and their weights were as follows: perinuclear antineutrophil cytoplasmic antibody (ANCA) or anti–myeloperoxidase‐ANCA positivity (+6), pauci‐immune glomerulonephritis (+3), lung fibrosis or interstitial lung disease (+3), sino‐nasal symptoms or signs (−3), cytoplasmic ANCA or anti–proteinase 3 ANCA positivity (−1), and eosinophil count ≥1 × 109/liter (−4). After excluding mimics of vasculitis, a patient with a diagnosis of small‐ or medium‐vessel vasculitis could be classified as having MPA with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the sensitivity was 91% (95% confidence interval [95% CI] 85–95%) and the specificity was 94% (95% CI 92–96%).ConclusionThe 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for MPA are now validated for use in clinical research.
Robust point‐to‐point iterative learning control for high speed trains with model uncertainty and wind gust
Authors: Li Zhenxuan , Hou Zhongsheng , Zhang Ruikun , Yin Chenkun 
Published: February 2022

AbstractIn this paper, a point‐to‐point iterative learning control strategy for a cascaded multibody high‐speed train (HST) system with model uncertainty and external disturbance is designed to address a specified given desired points tracking problem. The proposed method, which only used desired point information rather than whole trajectory information, is used to improve the multiple‐point tracking accuracy by enjoying the repetitiveness of an HST. A norm‐optimal method is employed in the ILC operating framework to analyze the HST model with parametric uncertainties and external disturbances. Both a rigorous mathematical analysis and detailed simulation results confirm the correctness and effectiveness of the proposed method.
Self‐discipline predictive control of autonomous vehicles against denial of service attacks
Authors: Sun Hong‐Tao , Peng Chen , Ding Fei 
Published: February 2022

AbstractThis paper presents a novel (SPC) scheme for the path following of autonomous vehicles (AVs) subject to denial of service (DoS) attacks. First, by considering the energy constraints of DoS attacks, bounded but arbitrary packet dropouts is used to characterize the effects of DoS attacks. Then, a switched control system model is established to describe the path following control of AVs under DoS attacks. In what follows, the SPC scheme, which depends on the detection of packet dropout from actuator side, is developed to compensate the packet dropout while there are no feedback measurements available. The main advantage of the proposed SPC scheme is that the predictive control design only depends on the latest available measurement and not affected by external disturbance. This is important to the control of networked systems under DoS attacks. At last, the corresponding experiments on path following control of the AVs are carried out in order to verify the validity of theory results.
Fair trade and consumer valuation: Purchase intentions in an emerging economy
Authors: De la Piedra‐Vindrola Sergio E. , Berbel‐Pineda Juan M. , Palacios‐Florencio Beatriz 
Published: February 2022

AbstractIn the scientific literature, there is little evidence of empirical research concerning the impact of fair trade (FT) on shopping behaviour (this is practically non‐existent, if we consider studies in emerging economies. For this reason, the aim of this research is to analyse to what extent consumers value FT practices in the context of an emerging economy and how these affect their purchase intentions. For this purpose, partial least squares structural equation modelling (PLS‐SEM) is used. The data are based on a sample of 409 consumers of an emerging economy (Peru). According to the results, the intention to purchase FT products by Peruvian consumers depends directly on the variables FT knowledge and attitude towards FT. Furthermore, the indirect influence on the purchase intention of the beliefs about FT variable is verified. On the other hand, the results obtained indicate that there are no differences between Peruvian women and men in terms of direct relations among model constructs. These results enable understanding consumer valuations of emerging economies concerning the responsible practices of firms. The study's findings have significant implications for the management of FT by public organisations and firms. There is evidence that consumers can start to value these FT policies, since they show a favourable disposition towards the consumption of products made or marketed with FT practices.
Dental implants at sites of focal high and mixed density osseous lesions: Treatment strategies
Authors: Akers Joshua A. , Johnson Thomas M. , Wagner Jennah C. , Vargas Sarah M. , Colamarino Aaron N. , Jenzer Andrew C. , Lincicum Adam R. , Hawie Jennifer B. , Lancaster Douglas D. 
Published: February 2022

AbstractFocused Clinical QuestionUnder what circumstances may a clinician consider dental implant placement at a site exhibiting a focal high or mixed density (HMD) osseous lesion radiologically?SummarySome conditions and pathologic entities exhibiting high and mixed density radiological appearance pose low risk for dental implant failure or complications following implant surgery. However, other lesions represent contraindications to implant placement, and implant surgery at such sites can result in severe morbidity.ConclusionPotential implant sites exhibiting focal HMD osseous lesions/conditions present varying levels of risk. In most cases, optimal management will include advanced imaging of the site, multidisciplinary consultations, and detailed informed consent to assure full understanding of procedural risks, benefits, and complications. Currently, clinical recommendations rely on case reports, opinion, and usual practice (level 3 evidence). The strength of each recommendation provided in this report is categorized as level C.
Liquid‐Liquid Centrifugal Extractors: Types and Recent Applications – a Review
Authors: Hamamah Zaid Alkhier , Grützner Thomas 
Published: February 2022

AbstractIn light of the elevating pressures toward adopting intensifying technologies, centrifugal extractors are increasingly drawing attention as a promising alternative to traditional extraction equipment. Recently, many fields have applied them in research and that resulted in a considerable amount of information that may be hard to follow. To keep interested researchers updated, this work presents the state‐of‐the‐art status of those devices. That is, the different types of centrifugal extractors are first surveyed with emphasis on those available on the market nowadays. Then, their recent applications are covered with exclusion of two fields: oil‐water separations and nuclear industry, as the purpose is to accent centrifugal extractors' potential and compatibility with the widest possible range of applications beyond traditional ones. A further section addresses the hydrodynamics of annular centrifugal contactors that form a major subfamily of centrifugal extractors. Those annular variants have received special focus throughout this work, since not only are they the most encountered devices in literature but also still to date under development with latest versions being 3D‐printed.
α‐Dioxygenases (α‐DOXs): Promising Biocatalysts for the Environmentally Friendly Production of Aroma Compounds
Authors: Kim In Jung , Bayer Thomas , Terholsen Henrik , Bornscheuer Uwe T. 
Published: February 2022

AbstractFatty aldehydes (FALs) can be derived from fatty acids (FAs) and related compounds and are frequently used as flavors and fragrances. Although chemical methods have been conventionally used, their selective biotechnological production aiming at more efficient and eco‐friendly synthetic routes is in demand. α‐Dioxygenases (α‐DOXs) are heme‐dependent oxidative enzymes biologically involved in the initial step of plant FA α‐oxidation during which molecular oxygen is incorporated into the Cα‐position of a FA (Cn) to generate the intermediate FA hydroperoxide, which is subsequently converted into the shortened corresponding FAL (Cn‐1). α‐DOXs are promising biocatalysts for the flavor and fragrance industries, they do not require NAD(P)H as cofactors or redox partner proteins, and they have a broad substrate scope. Here, we highlight recent advances in the biocatalytic utilization of α‐DOXs with emphasis on newly discovered cyanobacterial α‐DOXs as well as analytical methods to measure α‐DOX activity in vitro and in vivo.
Sinonasal mucosal melanoma presenting as a maxillary sinus mass: A case report
Authors: Gautam Kamal , Tiwari Sansar Babu , Shrestha Suraj , Gaire Prabin , Dulal Malati , Shrestha Bibek Man , Dhital Roman , Manandhar Usha , Baral Arun Kumar 
Published: February 2022

AbstractMaxillary sinus melanoma is a rare mucosal melanoma difficult to diagnose in the absence of pigmentation. Intranasal masses presenting with the features of occult malignancy and rapid progression should always be investigated in the line of melanoma irrespective of pigmentation. The histopathological and immunohistochemical examination helps to confirm the diagnosis.
CNT@MnO2 composite ink toward a flexible 3D printed micro‐zinc‐ion battery
Authors: Ren Yujin , Meng Fanbo , Zhang Siwen , Ping Bu , Li Hui , Yin Bosi , Ma Tianyi 
Published: February 2022

AbstractFlexible energy storage devices have played a significant role in multiscenario applications, while flexible zinc‐ion batteries (ZIBs), as an essential branch, have developed rapidly in recent years. Three‐dimensional (3D) printing is an extremely advanced technology to design and modify the structure of batteries and provides unlimited possibilities for the diversified development of energy storage equipment. Herein, by utilizing 3D printing technology, carbon nanotube (CNT) is coated by MnO2 to form a flexible CNT@MnO2 ink as a cathode for flexible aqueous micro‐ZIBs for the first time and zinc powder ink is used as an anode due to its high flexibility and bendability. The Zn//CNT@MnO2 flexible battery shows a stable capacity of 63 μAh cm−2 at 0.4 mA cm−2. When the battery is bent in different states, the maximum capacity loss compared with the initial value is only 2.72%, indicating its stability. This study shows the potential of 3D printing technology in the development of flexible manganese‐based ZIBs.
Evaluation and characterization of approximate arithmetic circuits
Authors: Catelan Daniela , Santos Ricardo , Duenha Liana 
Published: February 2022

SummaryWith the end of Dennard's scale, processor designers have been looking for new technical alternatives so that approximate computing (AC) has managed to attract the attention of researchers by offering techniques ranging from the application level to the circuit level. When applying approximate circuits into hardware design, the program user may speed up the application. At the same time, a designer may save area and power dissipation at the cost of less accuracy on the results of operations. This article discusses the compromise between controlled accuracy versus physical efficiency by evaluating a set of arithmetic circuits designs. The article also presents new mixed organization approximate designs. To evaluate the approximate design benefits, we performed a comprehensive set of experiments from tailor‐made approximate arithmetic circuits on field‐programmable gate array and application specific integrated circuits technologies. Our results reveal that our proposed mixed approximate designs have promising results on error rates, area usage, and power dissipation compared to the related work. Another interesting result is that one should care about the prototyping platform where the approximate hardware will be synthesized. Tailor‐made approximate cells may take advantage on intrinsic design details than standard cells or even general prototyping platforms.
Toward a reference architecture based science gateway framework with embedded e‐learning support
Authors: Pierantoni Gabriele , Kiss Tamas , Bolotov Alexander , Kagialis Dimitrios , DesLauriers James , Ullah Amjad , Chen Huankai , Fee David Chan You , Dang Hai‐Van , Kovacs Jozsef , Belehaki Anna , Herekakis Themistocles , Tsagouri Ioanna , Gesing Sandra 
Published: February 2022

AbstractScience gateways have been widely utilized by a large number of user communities to simplify access to complex distributed computing infrastructures. While science gateways are still becoming increasingly popular and the number of user communities is growing, the fast and efficient creation of new science gateways and the flexibility to deploy these gateways on‐demand on heterogeneous computational resources, remain a challenge. Additionally, the increase in the number of users, especially with very different backgrounds, requires intuitive embedded e‐learning tools that support all stakeholders to find related learning material and to guide the learning process. This paper introduces a novel science gateway framework that addresses these challenges. The framework supports the creation, publication, selection, and deployment of cloud‐based reference architectures that can be automatically instantiated and executed even by nontechnical users. The framework also incorporates a knowledge repository exchange and learning module that provides embedded e‐learning support. To demonstrate the feasibility of the proposed solution, two scientific case studies are presented based on the requirements of the plasmasphere, ionosphere, and thermosphere research communities.
Evidence‐based selection of reference genes for RT‐qPCR assays in periodontal research
Authors: Diehl Daniel , Friedmann Anton , Bachmann Hagen S. 
Published: February 2022

AbstractObjectiveTo underline the necessity of adequate reference genes for real‐time quantitative polymerase chain reaction (RT‐qPCR) and evaluate a novel tool for condition‐specific reference gene selection.BackgroundRT‐qPCR is a commonly used experimental technique that allows for highly sensitive analysis of gene transcription. Moreover, the use of internal reference genes as a means for relative quantification has rendered RT‐qPCR a straightforward method for a variety of sciences, including dentistry. However, the expressional stability of internal reference genes must be evaluated for every assay in order to account for possible quantification bias.Materials and MethodsHerein, we used the software tool RefGenes to identify putatively stable reference genes with the help of microarray datasets and evaluated them. Additionally, we propose an evidence‐based workflow for adequate normalization of thusly identified genes. Human gingival fibroblasts (HGF‐hTert), human acute leukemia‐derived monocytes (THP‐1), and telomerase immortalized gingival keratinocytes (TIGKs) were subjected to set‐ups simulating various glycemic conditions and lipopolysaccharide challenges. Five common housekeeping genes (HKGs) and five genes from RefGenes were selected as targets and RT‐qPCR was performed subsequently. Then, normalization algorithms Bestkeeper, Normfinder, and geNorm were used for further analysis of the putative reference gene stability.ResultsRefGenes‐derived targets exhibited the highest stability values in THP‐1 and TIGK cell lines. Moreover, unacceptable standard variations were observed for some common HKG like β‐actin. However, common HKG exhibited good stability values in HGF‐hTert cells.ConclusionThe results indicate that microarray‐based preselection of putative reference genes is a valuable refinement for RT‐qPCR studies. Accordingly, the present study proposes a straightforward workflow for evidence‐based preselection and validation of internal reference genes.