bluuebunny/crossref_metadata_2025_split huggingface dataset:
FRAGILIDADE AMBIENTAL POTENCIAL E EMERGENTE DA BACIA DO RIO MOCAJUBA – PA
Authors: Cavalcante Juliane costa , Lima Aline Maria Meiguins de , Silva Jéssica Cristina Conte da , Holanda Bruno Silva de , Almeida Crislayne Azevedo 
Published: June 2022

A análise das potencialidades de fragilidades ambientais de ambientes naturais e antropizados tem como finalidade adequar medidas de conservação, restauração e usos antrópicos destes ecossistemas, mantendo a perpetuação dos recursos naturais. Nessa perspectiva, o presente trabalho buscou identificar os diferentes níveis de fragilidade física na bacia hidrográfica do Rio Mocajuba – PA por meio da interação de elementos físicos e bióticos (pedologia, geologia, altitude, intensidade pluviométrica e uso e cobertura da terra) para a representação da paisagem local. Verificou-se que a bacia do Rio Mocajuba possui uma maior proporção de classes Média, Baixa e Alta, respectivamente, para Fragilidade Emergente e Potencial. Em que as áreas antropizadas promoveram o incremento da fragilidade natural, assim como observou-se que a classe de fragilidade baixa se concentrou na foz da bacia, englobando manguezais e áreas vegetadas. E a classe média e alta envolveram áreas de mangue e áreas antropizadas. Dessa forma a aplicação de metodologias de fragilidade possibilitam gerar um diagnóstico dos fatores limitantes ao uso e ocupação das terras. Assim como identificar áreas prioritárias para conservação e restauração florestal, contribuindo com a gestão e planejamento territorial da bacia.Palavras-chave: Fragilidade. Ecossistema. Alteração. Uso da Terra. Planejamento. Gestão. Potential and emerging environmental fragility of the Mocajuba river basin - PA A B S T R A C TThe analysis of the potential of environmental fragilities of natural and anthropized environments aims to adapt measures for conservation, restoration and anthropic uses of these ecosystems, maintaining the perpetuation of natural resources. In this perspective, the present work sought to identify the different levels of physical fragility in the hydrographic basin of the Mocajuba River - PA through the interaction of physical and biotic elements (pedology, geology, altitude, rainfall and land use and coverage) for representation of the local landscape. It was found that the Mocajuba River basin has a higher proportion of Middle, Low and High classes, respectively, for Emerging and Potential Fragility. Where the anthropized areas promoted an increase in natural fragility, just as it was observed that the class of low fragility was concentrated at the mouth of the basin, encompassing mangroves and vegetated areas. And the middle and upper class involved mangrove areas and man-made areas. Thus, the application of fragility methodologies makes it possible to generate a diagnosis of the factors limiting the use and occupation of land. As well as identifying priority areas for forest conservation and restoration. Contributing to the management and territorial planning of the basin.Keywords: Fragility. Ecosystem. Amendment. Land use. Planning. Management.
ANALISIS KUALITAS HAND SANITIZER DARI KOMBINASI VIRGIN COCONUT OIL (VCO) SEBAGAI PELEMBUT DAN ANTIBAKTERI DENGAN CAMPURAN ETANOL
Authors: Hitijahubessy Hendro , Parlindungan John Yoro 
Published: June 2022

Era pandemi Covid-19 dalam kehidupan masyarakat sangat dibutuhkan pelindung diri yang dapat menangkal virus korona, salah satu pelindung diri yang digunakan saat ini adalah hand sanitizer. Penelitian ini akan dibuat hand sanitizer dengan kombinasi Virgin Coconut Oil (VCO) dengan alkohol. Fungsi kedua bahan ini sebagai antibakteri memungkinkan paduan kedua bahan ini sangat efektif untuk dikombinasikan menjadi produk hand sanitizer. Metode pengujian yang dilakukan dalam penelitian ini adalah uji organoleptic dan uji zona bening untuk mengetahu kualitas dari hand sanitizer. Hasil penelitian yang diperoleh melalui uji organoleptik dan uji zona bening dapat disimpulkan bahwa hand sanitizer yang terbaik berada pada konsentrasi VCO 25% karena sifat lembut di area telapak tangan dan kemampuan zona hambat yang sangat kuat terhadap bakteri yang berasal dari tangan manusia sebesar 20,05 mm. Pemanfaatan kelapa sebagai tanaman pesisir untuk dijadikan VCO dan bahan dasar pembuat hand sanitizer maka diharapkan dapat digunakan dengan mudah oleh masyarakat.
Pengaruh Tutupan Hutan dan Lahan Terhadap Sektor Pertanian dalam Perekonomian Pendapatan Daerah: Studi Di Provinsi Lampung
Authors: Syahputra Aldy Mega , Bakri Samsul , Qurniati Rommy 
Published: June 2022

Deforestation and land cover changes are the upstream causal of the environmental performance and welfare, namely starting from declining hydro-orological functions, increased microclimate fluctuations, the emergence of shocks to the ecological balance, declining agricultural yields, declining incomes, further suppressing economic growth in the agricultural sector, which is generally followed by downstream sectors. The research was conducted in May - December 2020. The linear model postulate was applied at 5% and 10% significant levels with the response variable in the form of income from agricultural sector which was acquired from the BPS website, then optimization using Minitab. While the explanatory variables used are the proportion of land cover classes. Land and forest cover data were identified through the interpretation of Landsat satellite imagery downloaded from the NASA website using ArcGIS and Ecognition, then validation tests carried out with field exploration of the land cover class. The results of the research showed the relationship between the model equation R-Sq (adj) = 77.9% and the impact that occurred in each land cover class for each 1% decrease. Changes in the area of state forests, community forests, plantations, rice fields have an impact on decreasing the income of the agricultural sector respectively (IDR Million) 35.3; 16.7; 48.7; and 10.0. It suggest that conduct research on downstream economic activities such as inland fishery production, hydropower, industry, and trade.
The biochemical status of cows during the therapy of subclinical ketosis using natural zeolites and lecithin
Authors: Novikova I. A. , Dolgaya M. N. 
Published: June 2022

Relevance. Ketosis is a frequently observed disease in cattle, which is especially susceptible to highly productive cows after calving, and therefore the search for affordable and effective methods for the prevention and correction of this condition is actively pursued.Materials and methods. The biochemical parameters of the blood serum of Blackand-White cows with subclinical ketosis treated according to schemes that included propylene glycol, natural zeolites of the Khotynets deposit, and lecithin were studied. The biochemical composition of blood serum and the activity of enzymes in it were investigated in 4 groups of newly calved cows: 1 — clinically healthy (control); 2 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days; 3 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days and zeolites in the amount of 3% of the dry weight of the feed for 21 days; 4 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days, zeolites in the amount of 3% of the dry weight of the feed and 15 g of lecithin per 100 kg of live weight for 21 days.Research results. It was found that the restoration of the parameters of the biochemical composition of the blood serum of diseased cows to the levels of clinically healthy animals had been achieved on the 22nd day of therapy with the combined use of propylene glycol, natural zeolites and lecithin. The exception was the glucose content, which remained significantly increased by 14.0% compared to the control. The advantage of a complex treatment scheme over the main therapy used on the farm with the use of only propylene glycol is expressed in a significant increase on the 22nd day of the experiment in the blood serum of total protein by 7.0%, urea — by 17.5%, a decrease in cholesterol concentration by 29.0%, total bilirubin — by 27.5%, AST enzyme activities — by 31.9% and LDH — by 28.5%.
Indicators of antioxidant protection of the body of dairy cows depending on the phase of lactation and physiological state
Authors: Bogolyubova N. V. , Rykov R. A. 
Published: June 2022

Relevance. Studies on the assessment of the pro- and antioxidant status of the body of productive animalsare relevant, since they are interconnected with health, the state of the immune and reproductive systems. There is a steadily growing body of information in the field of oxidative stress in animal husbandry and veterinary medicine, which indicates the general importance of antioxidant defense of the body with impaired health and productivity of ruminants. There is a growing need to translate this knowledge into practical proposals for livestock specialists and veterinarians.Methods. In order to study the indicators of antioxidant protection in the body of dairy cows depending on the month of lactation and the physiological state, the following groups of cows were formed in the conditions of the PZ Ladozhsky (Krasnodar district) in the winter period of 2021: dry; lactating: 1 month; 2 months; 3 months; 4 months; 5 months; 6–7 months. The following indicators were determined in the blood of the studied animals: the concentration of ceruloplasmin, products reacting with thiobarbituric acid, the total content of water-soluble antioxidants, the general antioxidant status, and the antioxidant activity of blood serum.Results. The results obtained indicate changes in the antioxidant status in the body of cows, depending on the physiological state and month of lactation. By 5–6 months of lactation in the blood of cows the maximum levels of accumulation of LPO products are observed and the level of ceruloplasmin decreases, and the maintenance of the overall antioxidant status is carried out at the expense of other water-soluble antioxidants. The most significant changes in the studied parameters are observed between dry and lactating cows. The results obtained will allow monitoring the health status of animals and will serve as the accumulation of a database for the development of reference values for indicators of the antioxidant status in the body of dairy cows, depending on the physiological state and phase of lactation.
The influence of targeted selection on the exterior and productive indicators of Stavropol sheep in the dry steppe zone of the Volga region
Authors: Lakota E. A. , Vorontsova O. A. , Zamygin S. N. 
Published: June 2022

Relevance. Purposeful selection contributes to obtaining the optimal type of sheep of the Stavropol breed with improved exterior and productive parameters in the steppe conditions of the Volga region.Methods. The experiment took place in the CJSC “New Life” of the Novouzensky district of the Saratov region. The research material is purebred sheep of the Stavropol breed. Formation of experimental groups of queens (3): during selection into constitutionally productive types, an eye-dimensional assessment of external forms was used, which was specified by the measurements of body articles, live weight. In the first group were selected queens with a deviation to the strong type of constitution, in the second — to the gentle, in the third — to the loose. They mated with strong-type tups.Results. The offspring were formed: group I — from strong queens, II — tender, III — loose types. At birth, group III ewes had an advantage over I by 1.70%, over II — by 7.47%. Group I was superior in live weight to group II by 5.67%. In 4.5 months, “loose x strong” offspring exceeded “strong x strong” by 2.43%, “tender x strong” — by 12.27%. “Strong x strong” had an advantage over “gentle x strong” by 9.61%. According to the exterior at birth, the descendants of “loose x strong” surpassed “strong x strong”, “tender x strong” in chest width by 19.52; 5.78%; chest circumference — by 6.08; 10.99%, “strong x strong” prevailed over “gentle x strong” in chest width by 32%; chest circumference — by 4.62%. The trend of changing body measurements was observed at 4.5 monthsas well. According to the downness index at birth, “tender x strong” exceeded “strong x strong”, “loose x strong” by 8.03; 9.12%, at 4.5 months “strong x strong” had superiority over “tender x strong”, “loose x strong” by 3.77; 4.77%. All the young animals inherited the constitutional and productive characteristics of their parents, which is important in the inbreeding selection of sheep of the Stavropol breed in the Volga region.
Small-flowered clematis collections of the Stavropol Botanical Garden
Authors: Chebannaya L. P. 
Published: June 2022

Relevance. The biological features were studied, the average dates of the beginning, end and duration of the phenological phases of growth and development of species, forms and varieties of the genus Clematis (Clematis L.) were established. The assortment of small-flowered clematis for cultivation in the soil and climatic conditions of the Stavropol upland, characterized by high decorative properties, resistance to drought, pests and diseases, is highlighted.Methods. The object of research is small-flowered species, forms and varieties of the genus Clematis L., cultivated in the collection of the Stavropol Botanical Garden. The studies were conducted in 2012–2021 according to the methods of variety study and evaluation of the decorative qualities of clematis species and varieties.Results. The dates of the beginning and end of the growth of shoots are determined. According to the duration of shoot growth, all taxa are divided into groups: with a short growth period (38–51 days), medium (60–79 days); long (90–126 days). According to the timing of the beginning of flowering, the studied taxa are classified into five groups, most of them are included in the groups of early summer and summer flowering. According to the duration of flowering, three groups are distinguished — with short flowering, up to 30 days (C. jubata Bsch., C. recta L., C. recta f. atropurpurea, C. terniflora DC.); medium, from 41 to 60 days (С. fusca Turcz., C. ‘Bryzgi Morja’, C. integrifolia L., C. orientalis L., C. serratifolia Rehder, C. tangutica (Maxim.) Korsh., C. virginiana L., C. viticella L., C. viticella f. rosea); long-lasting, more than 60 days (C. ‘Fargesioides’, C. heracleifolia DC., C. hexapetala DC.).
The Component and Functional Pathways of Gut Microbiota Are Altered in Populations with Poor Sleep Quality – A Preliminary Report
Authors: Zhang Jianghui , Zhang Xueqing , Zhang Kexin , Lu Xiaoyan , Yuan Guojing , Yang Huayu , Guo Haiyun , Zhu Zhihui , Wang Tianli , Hao Jiahu , Sun Ying , Su Puyu , Zhang Zhihua 
Published: June 2022

Abstract
With the development of genome sequencing, many researchers have investigated the mechanism by which the intestinal microbiota influences sleep across the brain-gut axis. However, the relationship between gut microbiota and sleep disorder remains unclear. Thus, we studied the difference in gut microbiota composition between poor sleep quality- and normal populations, which helps set the ground for future research. The recruited college students provided baseline information and stool samples and completed the Pittsburgh Sleep Quality Index (PSQI). We compared the two groups’ gut microbiota composition and functional differentiation by using the 16S rRNA gene sequencing analysis. The main bacterial difference and the most critical effect were mainly concentrated within Tenericutes and Elusimicrobia. Compared with the healthy control group, some functions of the gut microbiota were impaired in the poor sleep quality group, such as butanoate metabolism and propanoate metabolism. Bacterial taxa with significant differences raised the possibility for future diagnosis and treatment of sleep problems.
Computer-Aided Design of α-L-Rhamnosidase to Increase the Synthesis Efficiency of Icariside I
Authors: Huang Jia-Jun , Hu Hao-Xuan , Lu Yu-Jing , Bao Ya-Dan , Zhou Jin-Lin , Huang Mingtao 
Published: June 2022

Icariside I, the glycosylation product of icaritin, is a novel effective anti-cancer agent with immunological anti-tumor activity. However, very limited natural icariside I content hinders its direct extraction from plants. Therefore, we employed a computer-aided protein design strategy to improve the catalytic efficiency and substrate specificity of the α-L-rhamnosidase from Thermotoga petrophila DSM 13995, to provide a highly-efficient preparation method. Several beneficial mutants were obtained by expanding the active cavity. The catalytic efficiencies of all mutants were improved 16–200-fold compared with the wild-type TpeRha. The double-point mutant DH was the best mutant and showed the highest catalytic efficiency (kcat/KM: 193.52 s−1 M−1) against icariin, which was a 209.76-fold increase compared with the wild-type TpeRha. Besides, the single-point mutant H570A showed higher substrate specificity than that of the wild-type TpeRha in hydrolysis of different substrates. This study provides enzyme design strategies and principles for the hydrolysis of rhamnosyl natural products.
Association Between Familial Hypercholesterolemia and Risk of Cardiovascular Events and Death in Different Cohorts: A Meta-Analysis of 1.1 Million Subjects
Authors: Yu Yani , Chen Lei , Zhang Honghong , Fu Zihao , Liu Qi , Zhao Haijing , Liu Yuqi , Chen Yundai 
Published: June 2022

Background and AimsThe association of familial hypercholesterolemia (FH) with risk of cardiovascular events (CVE) and death in different cohorts is controversial. We aimed to assess the risk of CVE and death in patients with FH in different cohorts, including CHD and ACS patients, White and Asian, different diagnostic criteria.MethodsWe searched PubMed, MEDLINE, and Web of Science electronic databases through May 2021 to identify cohort studies of CVE and death in patients with FH.ResultsWe found 18 eligible studies with 1,139,788 participants, including 34,261 patients. There were 31,287 ACS patients, of whom 2,338 were combined with FH. Randomized-effects meta-analysis showed that in patients with FH, relative risk (RR) of CVE and death was 1.87 (95% CI 1.21–2.88), among which CVE was 2.14 (95%CI 1.26–3.64), all-cause of death RR = 1.12 (95% CI 0.89–1.41), and cardiac death RR = 1.03 (95% CI 0.59–1.79). Risk of CVE and death in general population with FH was 2.85 (95% CI 0.72–11.21), hyperlipidemia population RR = 1.59 (95% CI 1.05–2.41), coronary heart disease patients (CHD) RR = 1.46 (95% CI 1.24–1.72), and acute coronary syndrome patients (ACS) RR = 1.71 (95% CI 1.19–2.46). Among ACS patients, the RR of CVE in patients with FH was 1.91 (95% CI 1.55–2.35), the RR of all-cause of death was 1.03 (95% CI 0.80–1.32), and the RR of cardiac death was 1.03 (95% CI 0.59–1.79). The risk of CVE and death in ACS patients with FH in White was 1.69 (95% CI 1.09–2.64) and Asian 1.90 (95% CI 1.31–2.75). RR in patients with Dutch Lipid Network criteria (DLCN) ≥6 vs. &lt;3 points was higher (RR = 2.24, 95% CI 1.69–2.97). RR for long-term follow-up was 1.68 (95% CI 1.09–2.61) and for short-term follow-up was 1.80 (95% CI 1.16–2.78). The results of the overall population were similar, but RR for overall population during a short-term follow-up was 1.49 (95% CI 0.81–2.73). We followed PRISMA checklist to complete meta-analysis.ConclusionsThe risk of CVE and death was increased in patients with CHD, especially in patients with ACS. DLCN ≥ 6 points was suggested for clinical diagnosis of FH. The risk of long-term and short-term CVE and death increased in ACS patients with FH.Registration NumberINPLASY2021110010.
Efficacy of Drug-Coated Balloon Approaches for de novo Coronary Artery Diseases: A Bayesian Network Meta-Analysis
Authors: Zhong Peng-Yu , Ma Ying , Shang Yao-Sheng , Niu Ying , Bai Nan , Wang Zhi-Lu 
Published: June 2022

Background and ObjectiveThe de novo coronary lesions are the most common form of coronary artery disease, and stent implantation still is the main therapeutic strategy. This network meta-analysis aims to evaluate the efficacy of drug-coated balloons only (DCB only) and DCB combined with bare-metal stents (DCB+BMS) strategies vs. drug-eluting stents (DES) and BMS approaches in coronary artery de novo lesion.MethodPubMed, EMBASE, and Cochrane Library databases were retrieved to include the relevant randomized controlled trials that compared DCB approaches and stents implantation in patients with de novo coronary artery diseases. The primary outcome was major adverse cardiac events (MACE). The clinical outcomes included target lesion revascularization (TLR), all-cause death, and myocardial infarction. The angiographic outcomes consisted of in-segment late lumen loss (LLL) and binary restenosis. The odds ratio (OR) and 95% confidence intervals (95% CIs) for dichotomous data, and weighted mean differences for continuous data were calculated in the Bayesian network frame.ResultA total of 26 randomized controlled trials and 4,664 patients were included in this study. The DCB-only strategy was comparable with the efficacy of MACE, clinical outcomes, and binary restenosis compared with DES. In addition, this strategy can significantly reduce the in-segment LLL compared with the first-generation (MD −0.29, −0.49 to −0.12) and the second-generation DES (MD −0.15, −0.27 to −0.026). However, subgroup analysis suggested that DCB only was associated with higher in-segment LLL than DES (MD 0.33, 0.14 to 0.51) in patients with acute coronary syndrome. Compared with DES, the DCB+BMS strategy had a similar incidence of myocardial infarction and all-cause death, but a higher incidence of MACE, TLR, and angiographic outcomes. In addition, DCB+BMS was associated with a similar incidence of myocardial infarction and all-cause death than BMS, with a lower incidence of MACE, TLR, and angiographic outcomes.ConclusionThe DCB only is associated with similar efficacy and lower risk of LLL compared with DES. In addition, the DCB+BMS strategy is superior to BMS alone but inferior to DES (PROSPERO, CRD 42021257567).Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails.
Predicting Late Recurrence of Atrial Fibrillation After Radiofrequency Ablation in Patients With Atrial Fibrillation: Comparison of C2HEST and HATCH Scores
Authors: Han Jingjing , Li Guangling , Zhang Demei , Wang Xiaomei , Guo Xueya 
Published: June 2022

ObjectiveThis study was aimed to investigate the risk of recurrence in patients with atrial fibrillation (AF) after radiofrequency ablation and predict risk of recurrence using C2HEST and HATCH scores.MethodsWe retrospectively included 322 patients with AF from Second Hospital of Lanzhou University, and 261 patients were included in the analysis finally. They had AF and were admitted for radiofrequency catheter ablation. We compared the ability of C2HEST and HATCH scores to predict recurrence after radiofrequency ablation of AF. The predictive ability of C2HEST and HATCH scores for AF recurrence was estimated by the area under the receiver operating characteristic curve (AUROC). The difference in receiver operating characteristic curve between the two models was compared using the DeLong test.ResultsOf the 261 patients included in the analysis, 83 (31.6%) patients suffered a late recurrence of AF after radiofrequency ablation. The risk of postoperative recurrence of AF increased with increasing C2HEST and HATCH scores. The AUROC of C2HEST and HATCH scores in predicting postoperative recurrence of AF was 0.773 (95%CI, 0.713–0.833) and 0.801 (95% CI, 0.740–0.861), respectively. There was no significant difference between the two models in their ability to evaluate patients for postoperative recurrence of AF (DeLong test p-value = 0.36). Among the risk factors in both models, hypertension and heart failure (HF) contributed the most to postoperative recurrence after AF, and higher blood pressure and lower cardiac ejection fraction (EF) were associated with a higher risk of recurrence.ConclusionBoth C2HEST and HATCH scores were significantly associated with the risk of late recurrence after radiofrequency ablation of AF. Besides hypertension and HF contributed the most to postoperative recurrence after AF.