bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic relatedness, virulence factors and antibiotics susceptibility pattern of Vibrio cholerae isolates from various regions during cholera outbreak in Tanzania
Authors: Matimba Hamza Hamad , Joachim Agricola , Mizinduko Mucho Michael , Maseke Irene Anthony , Nyanga Salum Kassim , Kelly Maria Ezekiely , Nyanga Ali Said , Mghamba Janneth Maridadi , Majigo Mtebe Venance , Mohamed Ahmed Abade 
Published: March 2022

Background
Cholera continues to cause morbidity and mortality in developing countries, including Tanzania. Since August 2015, Tanzania Mainland has experienced cholera outbreaks affecting 26 regions and a 1.6% case fatality rate. The current study determined the virulence factors, genetic relatedness and antimicrobial susceptibility patterns of the Vibrio cholerae isolated from different regions in Tanzania.

Methods
A cross-sectional study that involved the genetic characterization of V. cholerae isolates from eleven regions in Tanzania was carried out. There were 99 V. cholerae isolates collected between January 2016 and December 2017. The study perfomed a Multi-locus Variable-number tandem-repeat analysis for genetic relatedness and Mismatch Amplification Mutation Analysis polymerase chain reaction for analyzing toxin genes. All the isolates were tested for antimicrobial susceptibility using the Kirby Bauer disk diffusion method. Data were generally analyzed using Microsoft excel, where genetic relatedness was analyzed using eBurst software v3.

Results
All isolates were V. cholerae O1. Ogawa was the most predominant 97(98%) serotype. Isolates were genetically related with a small genetic diversity and were positive for ctxA, tcpA El Tor virulence genes. All isolates (100%) were sensitive to doxycycline, trimethoprim-sulphamethoxazole, tetracycline, ceftriaxone, and chloramphenicol, while 87.8% were sensitive to ciprofloxacin. A high resistance rate (100%) was detected towards erythromycin, nalidixic acid, amoxicillin, and ampicillin.

Conclusion
The V.cholerae O1 serotypes Ogawa, El Tor variant predominantly caused cholera outbreaks in Tanzania with strains clonally related regardless of the place and time of the outbreak. Most of the isolates were susceptible to the antibiotic regimen currently used in Tanzania. The high resistance rate detected for the other common antibiotics calls for continuous antimicrobial susceptibility testing during outbreaks.
The Union of Body and Mind in Early Modern Philosophy
Authors: Pavlovits Tamás , Schmal Dániel 
Published: March 2022

Foreword for the special issue of the journal Különbség (Difference). This issue intends to reconsider certain interpretative patterns regarding the distinction between soul and body by emphasising their union in Descartes, Spinoza, Leibniz, Pascal, Hobbes, Locke and other philosophers of the early modern age.
Targeted Albumin Infusions Do Not Improve Systemic Inflammation or Cardiovascular Function in Decompensated Cirrhosis
Authors: China Louise , Becares Natalia , Rhead Camilla , Tittanegro Thais , Freemantle Nick , O'Brien Alastair 
Published: March 2022

INTRODUCTION:
Albumin is recommended in decompensated cirrhosis, and studies have shown potential immunomodulatory effects. However, 2 large trials of repeated albumin infusions demonstrated contrasting results between outpatients and hospitalized patients. We investigated markers of systemic inflammation, immune function, albumin binding, and cardiovascular function using samples from Albumin To prevenT Infection in chronic liveR failurE (ATTIRE) taken at baseline, day 5, and day 10 of the trial to identify why targeted albumin infusions had no effect in hospitalized patients.

METHODS:
Plasma samples were analyzed from 143 patients (n = 71 targeted albumin; n = 72 standard care at baseline) for cytokines, cardiovascular markers, prostaglandin E2, the effect of plasma on macrophage function, and albumin radioligand binding and oxidation status. The sample size was based on our feasibility study, and samples were selected by a trial statistician stratified by the serum albumin level and the presence of infection at randomization and analyses performed blinded to the study arm. Data were linked to 3-month mortality and treatment groups compared.

RESULTS:
Increased baseline model for end-stage liver disease score, white cell count, calprotectin, CD163, tumor necrosis factor, renin, atrial natriuretic peptide, and syndecan-1 were associated with 3-month mortality. Despite infusing substantially differing volumes of albumin, there were no significant differences in inflammatory markers, albumin–prostaglandin E2 binding, or cardiovascular markers between treatment arms.

DISCUSSION:
Contrary to many preclinical studies, targeted intravenous albumin therapy in hospitalized decompensated cirrhosis had no effect across a broad range of systemic inflammation, albumin function, and cardiovascular mediators and biomarkers compared with standard care, consistent with the null clinical findings.
Oxygen diffusion pathways in mutated forms of a LOV photoreceptor from Methylobacterium radiotolerans: A molecular dynamics study
Authors: Zerlotti Rocco , Losi Aba , Polverini Eugenia 
Published: March 2022

Abstract

Mr4511 from Methylobacterium radiotolerans is a photoreceptor of the light, oxygen voltage (LOV) family, binding flavin mononucleotide (FMN) as a chromophore. It exhibits the prototypical LOV photocycle, with the reversible formation of an FMN-Cys71 adduct via fast decay of the FMN triplet state. Mr4511 has high potential as a photosensitiser for singlet oxygen (SO) upon mutation of C71. Mr4511-C71S shows a triplet lifetime (τ
T) of several hundreds of microseconds, ensuring efficient energy transfer to dioxygen to form SO. In this work, we have explored the potential diffusion pathways for dioxygen within Mr4511 using molecular dynamics (MD) simulations. The structural model of wild-type (wt) Mr4511 showed a dimeric structure stabilised by a strong leucine zipper at the two C-terminal helical ends. We then introduced in silico the C71S mutation and analysed transient and persistent oxygen channels. MD simulations indicate that the chromophore binding site is highly accessible to dioxygen. Mutations that might favour SO generation were designed based on their position with respect to FMN and the oxygen channels. In particular, the C71S-Y61T and C71S-Y61S variants showed an increased diffusion and persistence of oxygen molecules inside the binding cavity.
Spatial mixture modeling for analyzing a rainfall pattern: A case study in Ireland
Authors: Hussein Amjad , Kadhem Safaa K. 
Published: March 2022

Abstract
This study investigates the spatial heterogeneity in the maximum monthly rainfall amounts reported by stations in Ireland from January 2018 to December 2020. The heterogeneity is modeled by the Bayesian normal mixture model with different ranks. The selection of the best model or the degree of heterogeneity is implemented using four criteria which are the modified Akaike information criterion, the modified Bayesian information criterion, the deviance information criterion, and the widely applicable information criterion. The estimation and model selection process is implemented using the Gibbs sampling. The results show that the maximum monthly rainfall amounts are accommodated in two and three components. The goodness of fit for the selected models is checked using the graphical plots including the probability density function and cumulative distribution function. This article also contributes via the spatial determination of return level or rainfall amounts at risk with different return periods using the prediction intervals constructed from the posterior predictive distribution.
Minimizing form errors in additive manufacturing with part build orientation: An optimization method for continuous solution spaces
Authors: Leirmo Torbjørn L. , Semeniuta Oleksandr 
Published: March 2022

Abstract
For additive manufacturing (AM) to be successfully implemented in manufacturing systems, the geometric accuracy of components must be controlled in terms of form, fit, and function. Because the accuracy of AM products is greatly affected by the part build orientation, this factor dictates the achievable tolerances and thereby the ability to incorporate AM technologies in a large-scale production. This article describes a novel optimization method for minimizing form errors based on the geometric features of the part. The described method enables the combination of separate expressions for each feature to create a continuous solution space. Consequently, the optimal part build orientation can be precisely determined based on a mathematical description of the effect of build direction on each surface type. The proposed method is demonstrated in two case studies by step-by-step descriptions including discussions on viability and possible extensions. The results indicate good performance and enable flexible prioritization and trade-offs between tolerance characteristics.
On upper and lower fast Khintchine spectra of continued fractions
Authors: Fang Lulu , Shang Lei , Wu Min 
Published: March 2022

Abstract
Let

ψ
:

ℕ
→

ℝ
+

{\psi:\mathbb{N}\to\mathbb{R}^{+}}

be a function satisfying

ϕ
⁢

(
n
)

n

→
∞

{\frac{\phi(n)}{n}\to\infty}

as

n
→
∞

{n\to\infty}

. We investigate from a multifractal analysis point of view the growth rate of the sums

∑

k
=
1

n

log
⁡

a
k

⁢

(
x
)

{\sum^{n}_{k=1}\log a_{k}(x)}

relative to

ψ
⁢

(
n
)

{\psi(n)}

, where

[

a
1

⁢

(
x
)

,

a
2

⁢

(
x
)

,
…
]

{[a_{1}(x),a_{2}(x),\dots]}

denotes the continued fraction expansion of an irrational

x
∈

(
0
,
1
)

{x\in(0,1)}

. For

α
∈

[
0
,
∞
]

{\alpha\in[0,\infty]}

, the upper (resp. lower) fast Khintchine spectrum is considered as a function of α which is defined by the Hausdorff dimension of the set of all points x such that the upper (resp. lower) limit of

1

ψ
⁢

(
n
)

⁢

∑

k
=
1

n

log
⁡

a
k

⁢

(
x
)

{\frac{1}{\psi(n)}\sum^{n}_{k=1}\log a_{k}(x)}

is equal to α. These two spectra have been studied by Liao and Rams (2016) under some restrictions on the growth rate of ψ. In this paper, we completely determine the precise formulas of these two spectra without any conditions on ψ.
Synthesis, structural and magnetic characterization of spherical high entropy alloy CoCuFeNi particles by hydrogen reduction assisted ultrasonic spray pyrolysis
Authors: Küçükelyas Burak , Safaltın Şerzat , Sam Ebru Devrim , Gurmen Sebahattin 
Published: March 2022

Abstract
The present study focuses on the synthesis, structural and magnetic characterization of CoCuFeNi high entropy alloy particles. The hydrogen reduction assisted ultrasonic spray pyrolysis method was used to synthesize nanocrystalline quaternary CoCuFeNi particles in a single step. The effect of synthesis temperature on the structure, morphology and the size of particles was investigated. The syntheses were performed at 700 °C, 800 °C, and 900 °C with 0.1 M concentration of metal nitrate salts precursor solution. The structure and morphology of products were characterized through X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy and vibrating sample magnetometer studies. Diffraction pattern based calculations revealed that crystallite sizes of CoCuFeNi particles were in the range of 15.6–26.7 nm. Scanning electron microscopy and energy dispersive spectroscopy investigations showed that particles were agglomerated from crystallites and in spherical morphology with equiatomic elemental composition. According to vibrating sample magnetometry results, soft magnetic properties were observed for CoCuFeNi particles. X-ray photoelectron spectroscopy results showed that the surface has a thin layer of copper oxide.
Debunkings de dicto and de re
: Brandom on Genealogical Explanation
Authors: Wolf W. Clark 
Published: March 2022

Abstract
One of the most surprisingly prominent themes in Robert Brandom’s A Spirit of Trust is the role of genealogical explanations. Brandom sees genealogies or ‘debunking arguments’ as significant because of their ability to deprive our discursive acts (claims and actions) of the normative status they require to be genuinely discursive or conceptual. His solution to the problem of genealogy is to offer rationalizing reconstructions of others’ discursive acts, which credit them with normative status. He calls this “forgiveness” (a notion similar to Davidson’s “charity”). In this paper, I provide some additional conceptual resources to explicate Brandom’s notions of genealogy and forgiveness. These resources allow me to discriminate between two alternate and seemingly incompatible ways of responding to genealogies. One way depends on rationalizing explanations that still attempt to attribute commitments to their subjects, the other avoids making such attributions in favor of explaining commitments only in terms of norms accepted by the rationalizer. I argue that Brandom’s work sometimes promotes the latter response to genealogy but that this tendency should be eliminated from the account.
On one way of modeling a stochastic process with given accuracy and reliability
Authors: Ianevych Tetiana , Rozora Iryna , Pashko Anatolii 
Published: March 2022

Abstract
The paper is devoted to one possible way of the model
construction for the stationary Gaussian process with given
accuracy and reliability in functional space

C
⁢

(

[
0
,
T
]

)

{C([0,T])}

.
Zeiterfassung, Kostenermittlung und Bewertung von Projekten ohne PPS-Systeme
Authors: Schwarz Ramona , Schwarz Joachim 
Published: March 2022

Abstract
Die benötigte Arbeitszeit je Kostenstelle und Projekt und die nachkalkulatorische Projektkostenermittlung stellen wesentliche Steuerungsgrößen für Fertigung und Unternehmen dar. Die Bewertung unfertiger Erzeugnisse ist insbesondere bei mehrmonatigen Durchlaufzeiten wesentlich für die Einschätzung der Ergebnis-Situation des Betriebes. Der Beitrag beschreibt eine Vorgehensweise, wie ohne Verwendung eines PPS-Systems mit Standardprogrammen eine weitgehend automatisierte Ermittlung dieser Größen erfolgen kann.
Innovative Schleifverfahren zur Keramikbearbeitung
Authors: Uhlmann Eckart , Holl Sven-Erik , Ardelt Thomas , Sroka Frank , Laufer Jörgen 
Published: March 2022

Abstract
Bezüglich wirtschaftlicher Produktionstechnologien besteht insbesondere in Hinblick auf die Großserienfertigung hochbeanspruchter keramischer Bauteile nach wie vor erheblicher Forschungsbedarf. Dieser zweiteilige Artikel stellt aktuelle Forschungsvorhaben zur Keramikbearbeitung des Instituts für Werkzeugmaschinen und Fabrikbetrieb der TU Berlin vor. Der erste Teil beschäftigt sich mit dem ultraschallunterstützten Schleifen sowie dem Planschleifen mit Läppkinematik. Die Schwerpunkte des zweiten Teils werden in der Abrichttechnologie und der Kühlschmierung beim Schleifen von keramischen Werkstoffen liegen.
Zielorientiertes EDM durch Axiomatic Design
Authors: Spath Dieter , Lanza Marco , Sauter Gisela 
Published: March 2022

Abstract
Konventionelles Engineering Data Management (EDM) gewährleistet zwar die Verwaltung von Informationen, unterstützt verteilte Entwicklungs- und Planungsteams aber nicht im methodischen Vorgehen durch Konstruktionsmethoden wie z.B. Axiomatic Design. Ziel einer Forschungsarbeit
Der Forschungsschwerpunkt „Branchenübergreifende Informationslogistik für die Produktentwicklung in der Investitionsgüterindustrie" des Landes Baden-Württemberg dient dazu, neue Modelle, Methoden und Systeme zur Planung, Initiierung und Koordination von Informationsflüssen von der ersten Projektidee bis zur Endpräsentation zu entwickeln.
war die Gestaltung eines Axiomatic Designbasierten Projektmanagements zur Unterstützung der Fertigungssystemplanung. Es wurde in ein EDM-System eingebettet.
EFEKTIVITAS KONSELING INDIVIDUAL DENGAN PENDEKATAN KONSELING CLIENT CENTERED DALAM MENINGKATKAN KEDISIPLINAN SISWA DI SMA N 1 DUA KOTO
Authors: Warni Delita , Junaidi Junaidi , Wae Rahmawati 
Published: March 2022

Penelitian ini beranjak dari fenomena banyaknya peserta didik yang melakukan pelanggaran disiplin dalam mematuhi tata tertib sekolah. Untuk mereduksi tingkat pelanggaran tersebut guru BK berupaya mengatasinya melalui beberapa jenis layanan salah satunya dengan layanan konseling individual namun hasilnya belum optimal. Peneliti mencoba melakukan layanan konseling individual dengan pendekatan client centered. Tujuan yang akan dicapai dalam penelitian ini adalah untuk mengetahui efektivitas pendekatan konseling client centered dalam meningkatkan kedisiplinan siswa. Penelitian ini tergolong penelitian pre eksperimen model One Group Pretest-Posttest Design. Populasi penelitian ini adalah siswa kelas XI IPS yang berjumlah 83 orang, sedangkan sampel penelitian adalah 7 siswa yang terindikasi memiliki tingkat pelanggaran disiplin tinggi berdasarkan teknik non random sampling dan rekomendasi guru BK. Instrumen pengumpulan data adalah skala likert. Uji hipotesis menggunakan Statistical Product and Service Solution (SPSS) versi 22. Hasil penelitian yang telah dilakukan terdapat perbedaan antara nilai pretest dengan nilai posttest. Dari hasil test statistik mengunakan uji Wilcoxon diperoleh nilai signifikansi p-value sebesar 0,018 pada taraf signifikan 0,05. Berdasarkan ketentuan yang berlaku pada Uji Wilcoxon maka dapat dikatakan Ho ditolak artinya pendekatan konseling client centered efektif dalam meningkatkan kedisiplinan siswa.
HUBUNGAN ANTARA KEPERCAYAAN DIRI DENGAN PENYESUAIAN SOSIAL PESERTA DIDIK KELAS VII MTsN 7 KOTA PADANG
Authors: Putra Tomi , Wati Hasna , Anidar Jum 
Published: March 2022

Kepercayaan diri dan penyesuaian sosial merupakan dua hal yang berkaitan. Pada peserta didik tingkat Sekolah Madrasah Tsanawiyah (MTS) memiliki kepercayaan diri dan penyesuaian sosial merupakan hal yang penting dimiliki peserta didik. Penelitian ini bertujuan untuk melihat gambaran hubungan kepercayaan diri dan penyesuaian sosial peserta didik. Desain penelitian menggunakan rancangan korelasi. Peneliti mengumpulkan data kepercayaan diri dengan mengacu pada aspek‐aspek yang dikemukakan oleh Lauster dan Guilford dan penyesuaian sosial dengan mengacu pada aspek-aspek yang dikemukakan oleh Hurlock yang sudah diuji validitas dan reliablitasnya. Sampel yang digunakan pada penelitian ini yaitu 68 peserta didik di MTsN VII Kota Padang yang diambil melalui teknik purposive sampling. Adapun hasil pengolahan data menunjukkan sebagian besar peserta didik kelas VII MTsN 7 Kota Padang memiliki kepercayaan diri dan penyesuaian sosial yang sedang, dan analisis data menunjukkan bahwa terdapat hubungan antara kepercayaan diri dan penyesuaian sosial peserta didik. Dengan hasil analisis korelasi product moment Pearson yaitunilai r hitung> nilai r tabel yaitu 0,631 > 0,224 dan nilai signifikansi 0,000 < 0,05. Hipotesis yang diajukan dalam penelitian ini dinyatakan diterima. Jadi dapat disimpulkan bahwa semakin tinggi kepercayaan diri seseorang maka penyesuaian juga baik, begitupun sebaliknya.
PERILAKU MENYONTEK DI KALANGAN PESERTA DIDIK DI SMPN 3 KOTO XI TARUSAN
Authors: Wulandari Ayu , A Hallen , Zen Wahyuli Lius 
Published: March 2022

Penelitian ini dilatarbelakangi adanya ditemukan perilaku menyontek di kalangan peserta didik. Melalui penelitian ini peneliti ingin mengetahui apa yang melatarbelakangi perilaku menyontek di kalangan peserta didik, faktor faktor penyebab munculnya perilaku menyontek dan bentuk bentuk perilaku menyontek di kalangan peserta didik. Penelitian ini dilakukan di SMPN 3 Koto XI Tarusan dengan mengunakan metode deskriptif melalui pendekatan kualitatif. Data penelitian dikumpulkan dengan mengunakan teknik observasi, wawancara dan dokumentasi. Wawancara dilakukan kepada peserta didik, wali kelas dan guru Bimbingan Konseling SMPN 3 Koto XI Tarusan. Data penelitian yang diperoleh selanjutnya dianalisa dengan cara mendeskripsikan, mengkombinasikan dan mengintegrasikan berbagai unsur yang terpisah selama pengumpulan data sehingga dapat menjadi sesuatu kesatuan untuk ditarik menjadi kesimpulan. Melalui penelitian ini dapat disimpulkan bahwa yang melatarbelakangi perilaku menyontek dikalangan pelajar adalah rendahnya minat belajar, kebiasaan menunda tugas, kurang percaya diri terhadap kemampuan sendiri, keinginan nilai tinggi, pikiran negatif, dan kecemasan yang berlebihan. Selain itu ditemukan bahwa rasa tidak percaya diri, kebiasaan, malas, teman sebaya dan tuntutan berlebihan dari orang tua merupakan faktor penyebab munculnya perilaku menyontek di kalangan pelajar. Sedangkan bentuk-bentuk perilaku menyontek yang dilakukan oleh peserta didik yaitu melihat jawaban teman, melihat internet, menulis di atas meja, kode tangan dan membuat catatan kecil.
PERBANDINGAN PENDIDIKAN MASYARAKAT SEDERHANA DAN PENDIDIKAN MASYARAKAT MODERN
Authors: Rasdiany Apriana Nofriastuti , Firman Firman , Ahmad Riska 
Published: March 2022

Perbedaan hasil pendidikan masyarakat sederhana dan masyarakat modern mendasari penulisan artikel ini. Masyarakat modern membutuhkan durasi yang lebih lama dalam mendidik buah hatinya untuk mencapai kualitas pendidikan terbaik dibandingkan dengan masyarakat sederhana. Pada masyarakat modern dibutuhkan tenaga profesional, lembaga formal dan sarana dan prasarana yang mencukupi untuk mengajarkan pengetahuan agar mempunyai kemampuan sebanding dengan perancangan RPP. Sedangkan masyarakat sederhana kurang memerlukan institusi dalam pendidikan untuk mencapai kecakapan dan keahlian yang minimal dibutuhkan oleh masyarakat sederhana.Masyarakat sederhana tidak membutuhkan individu yang ahli dalam membimbing sehingga hasil mengajar mereka penuh dengan kebutuhan kehidupan masyarakat di sekitar. Anak Masyarakat moderncenderung memiliki tekanan dari orang tua serta pendidiknya agar mereka menguasai bidang dalam durasi yang telah ditentukan. Hal ini tentu menyebabkan masalah psikis pada anak masyakat modern. Pendidikan masyarakat modern lebih diarahkan pada keinginan untuk mencapai kualitas pendidikan terbaik sedangkan mayarakat sederhana lebih diarahkan pada kebutuhan keahlian minimal yang dibutuhkan masyarakat sekitar.
HUBUNGAN SELF CONTROL DENGAN INTERNET ADDICTION PADA SISWA SMP DI KABUPATEN TEMANGGUNG
Authors: Dwy Susantika , Isrofin Binti 
Published: March 2022

Jumlah pengguna internet dikalangan anak dan dewasa terus berkembang, dengan rendahnya self control dapat mendorong terjadinya perilaku internet addiction pada siswa. Penelitian ini bertujuan untuk mengetahui hubungan self control dengan internet addiction pada siswa SMP di Kabupaten Temnggung. Penelitian ini dilakukan menggunakan metode penelitian kuantitatif korelasional. Populasi pada penelitian ini ialah siswa SMP N 5 Temanggung, SMP N 1 Pringsurat, dan SMP Salomo 3 Pringsurat. Sampel yang digunakan berjumlah 250 dari 686 siswa dengan menggunakan purposive sampling dan random sampling. Alat pengumpul data yang digunakan ialah skala internet addiction,dan skala self control. Kemudian, data dianalisis menggunakan analisis regresi sederhana dengan bantuan JASP. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara self control dengan internet addiction pada siswa (β i= i0,563; it=10,379; ip i<0,01). Berdasarkan hasil penelitian tersebut, disarankan bagi guru BK agar memberikan layanan yang dapat mengurangi tingkat internet addiction pada siswa dengan melibatkan tingkat self control siswa.