bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a transgenic tissue visualization system in representatives of <i>Fabaceae</i>
Authors: Kozlov Nikolai V. , Simonova Veronika Y. , Krasnoperova Elizaveta Y. , Potsenkovskaia Elina A. , Tvorogova Varvara E. , Lutova Ludmila A. 
Published: December 2022

Plant organisms are the objects of green biotechnology, which have been used by humans in various areas of life. The family of legumes (Fabaceae) that is being studied in this work is not an exception here. It is a very diverse family widespread throughout the globe.
Barrel medic (Medicago truncatula) and common pea (Pisum sativum), members of the legume family, were selected in this study for the development of an vital imaging system for transgenic tissues. As a part of the work, we tested an imaging system with post-mortem staining based on the GUS reporter, as well as a system for vital detection of transgenic tissue with fluorescent proteins GFP and DsRed. At this stage, vital imaging systems based on betalain and anthocyanin staining of transgenic tissues are designed and currently being adapted to the model objects under study.
The results of this study may be useful for subsequent attempts to solve the problem of the low efficiency of transformation of P. sativum. Moreover, such a system should be useful in the study of gene regulatory networks and factors that regulate the process of induction and subsequent development of somatic embryos. In addition, it can be used to track the dynamics of expression of genes of interest on living objects, while studying other fundamental and biotechnological processes.
The study is supported by the Russian Foundation for Basic Research (20-016-00124).
Legal aspects of new genetic technologies
Authors: Bruskin Sergey A. 
Published: December 2022

The development of genomic editing technologies has significantly intesificated the shortcomings of the legal regulation for genetic technologies as in general and as for new technologies of genetic engineering in particular. Because of imperfected legislation for genetic engineering, and in some cases because of its archaism, new genomic technologies, such as genetic editing technologies, which are growth drivers in science, could not be drivers in the economics. The outdated terms and concepts framework and the legal indetermination of using the products based on new genetic technologies (including genome editing) are barriers to achieving the goals to ensure the technological independence of Russia.
The basis of the current legal regulation system of genetic engineering in Russia is a focus to the process and technologies, i.e. methods of the product producing. This means that the changes within genetic information is not important, but only the method of development is. Such way of regulation provides a priori chronic lag in legislation, which could finally lead to technological lag as whole country. The transition to a product-oriented system, when the analysis of base of genetic information changes makes possible to clearly answer to the question of the methods used for this, will allow us to avoid the shortcomings within development of synthetic biology methods indicated earlier, as now as in the future.
Investigating Injection Pressure as a Predictor to Enhance Real-Time Forecasting of Fluid-Induced Seismicity: A Bayesian Model Comparison
Authors: Feng Yu , Mignan Arnaud , Sornette Didier , Gao Ke 
Published: December 2022

AbstractFluid-induced seismicity is now a growing concern in the spotlight and managing its risks entails a probabilistic forecast model suited to real-time applications, which commonly relies on the operational parameter of injection rate in a nonhomogeneous Poisson process. However, due to potential injectivity change, gas kicks, and other processes, injection rate may not provide as robust a proxy for the forcing process as injection pressure, which embodies fluid–rock interactions. Hence, we present a Bayesian approach to prospective model comparison with parameter uncertainties considered. We tested nine geothermal stimulation case studies to comprehensively demonstrate that injection pressure is indeed the main physical predictor of induced seismicity relative to injection rate, and when combined with the latter as predictors, can give the best-performing model and robustly enhance real-time probabilistic forecasting of induced seismicity. We also discussed the implications of our results for seismic risk management and potential directions for further model improvement.
Al-Musykilât Fî Dirâsati Al-Imla’ Lada Thullâbi Al-Jâmi’ah Wa Tahlîluhâ
Authors: Syamsiyah Barid 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui problematika pembelajaran imla’ dan pemberian solusinya pada mahasiswa PBA di IAIN Salatiga. Penelitian ini merupakan penelitian kualitatif lapangan dengan menggunakan metode observasi, wawancara dan dokumentasi dalam pengumpulan sumber data. Teknik Analisis data penelitian menggunakan teknik analisis deskriptif. Adapun hasil penelitian menunjukkan bahwa problematika pembelajaran imla’ disebabkan oleh beberapa faktor yaitu faktor internal dan faktor eksternal. Faktor internal meliputi siswa, guru, materi dan metode pembelajaran. Adapun faktor eksternal meliputi faktor pembelajaran imla’ meliputi kaidah-kaidah pembelajaran imla’. Adapun dalam mengatasi problematika pada pembelajaran imla’ mahasiswa yaitu memperbanyak kosakata dan latihan menulis, perhatian yang lebih pada kaidah-kaidah imla’ baik secara teori maupun praktek, menentukan materi imla’ dari yang mudah dan yang sulit serta pentingnya pengajar yang profesional yang ahli dalam pembelajaran imla’.
PEMENUHAN DAN PERLINDUNGAN HAK PENYANDANG DISABILITAS DI RUANG PUBLIK PADA PERATURAN DAERAH KABUPATEN SEMARANG NOMOR 12 TAHUN 2021 PERSPEKTIF MAQASHID SYARI’AH (Studi di Kecamatan Bringin, Kabupaten Semarang)
Authors: Huda Ilham Nailul 
Published: December 2022

Pelaksanaan pemenuhan dan perlindungan hak penyandang disabilitas dalam fasilitas ruang publik perlu memperhatikan Peraturan Daerah Kabupaten Semarang Nomor 12 Tahun 2021. Hal ini telah mempunyai indikator khusus pada Pasal 39 ayat (1) dan (2) terkait infrastruktur pada fasilitas ruang publik. Tujuan penelitian ini adalah untuk mengetahui bagaimana pemenuhan dan perlindungan penyandang disabilitas ruang publik yang ada di Kecamatan Bringin terhadap Peraturan Daerah Kabupaten Semarang Nomor 12 Tahun 2021 perspektif Maqashid Syari’ah. Penelitian ini merupakan penelitian yuridis sosiologis dengan bersifat penelitian deskriptif-analisis. Metode pengumpulan data dilakukan dengan sumber informasi langsung dari narasumber, aturan peraturan daerah terkait pemenuhan dan perlindungan penyandang disabilitas. Permasalahan yang ditemukan dalam penelitian ini, kemudian dianalisis menggunakan pendekatan yuridis sosiologis dengan jenis penelitian Field Research yang didasarkan pada hukum positif Indonesia dan beberapa teori hukum Islam. Hasil penelitian pemenuhan dan perlindungan penyandang disabilitas ruang publik pada peraturan daerah Kabupaten Semarang nomor 12 tahun 2021 perspektif maqashid syari’ah, yakni Kecamatan Bringin harus membuat kebijakan terhadap fasilitas ruang publik yang kurang ramah bagi penyandang disabilitas. Adanya koordinasi terhadap proses pembangunan pada masyarakat sipil. Prioritas dalam pembangunan yang aksesibilitas bagi penyandang disabilitas (difabel) berdasarkan pada Pasal 39 ayat (2) yang diperjelas pada peraturan menteri pekerjaan umum nomor 30 tahun 2006 pada Pasal 4 ayat (1) huruf a sampai p. Hasilnya adalah dalam ruang publik Kecamatan Bringin yaitu kantor Kecamatan Bringin, bangunan gedung, pasar tradisional, masjid dan taman karanglo bringin belum sepenuhnya sesuai. Pembangunan ramah hanya di kantor kecamatan saja kurangnya pemerataan dalam fasilitas ramah penyandang disabilitas dan belum sepenuhnya sesuai jika dilihat dari maqashid syari’ah.
Financial stability and independence of municipalities in Ukraine
Authors: Bui Tetiana , Zenchenko Anastasiia 
Published: December 2022

The article assesses the local budgets independence using statistiсal methods and includes system dynamics research with a simplified explanatory model of aggregated municipal deposits. Using the method of analytical equalization, the share of local budgets’ own funds was calculated, as they are a source of financial stability and independence.A system dynamics hypothesis and model revealed important feedback mechanisms that play a role in financial autonomy and general financial well-being of municipalities – a higher deficit drives a higher debt that drives a higher deficit back; lower local tax revenues will bring higher transfers in the upcoming year; negative population growth decreases consumption, labor force, and other indicators, etc. The general reason for low financial autonomy lies in high dependency on transfers and income-based taxes, while taxes that are classified as local lay on businesses, which need more support. Some aspects revealed the need for deeper research and addition to the model – municipal borrowing and property markets. The model has been validated and built confidence through various tests, but yet it has serious assumptions, limitations, and aspects outside of the model boundary. Nevertheless the model has a potential for expansion and solving mode issues regarding this system or to be recalibrated for specific reasons and areas. The research can be used by the municipalities in Ukraine and needs to be updated with new data and expanded.
JEL classification: E62, H21, H61, H72
Quantitative indexes of monopoly and problems of their implementation in antitrust regulation
Authors: Tkachova Valeriia , Bandura Oleksandr 
Published: December 2022

We considered the quantitative indexes to control different monopoly’s types and identified the main disadvantages, which obstacle the usage of these indicators in practice of the antitrust regulation. Economic methods of antitrust control can be divided into two groups: (1) direct and (2) indirect. The direct ones are based on the market and competitive prices analysis, marginal revenue (MR) and marginal costs (MC) and theoretically, they permit to evaluate directly the negative monopoly’s impact on the market. Indirect methods are based on the non-price indexes (for instance, concentration or share of the firm on market) and identify only the potential hazard from monopoly. However they do not permit to determine whether monopoly indeed negatively impacts on market and in addition the level of such impact. By analyzing of some disadvantages of the monopoly control indexes, we determined several main features, which should have belonged to the new more perfect monopoly index, which would be the subject of our further investigation: (1) to be a dynamic (not a static one) quantitative index of the monopoly power, which evaluates both the fact of the monopoly power existence and the level of the power’s manifestation on the different hierarchical levels (economy, industry, firm) in the mode of real time; (2) to have a capability to separate in the new indicator the innovational component of the monopolist’s costs on the different hierarchical stages; (3) to display the correlation between the monopoly’s power index and the business cycle phases, since the level of the negative monopoly’s impact may be intensified in the recession phase and may be weakened in the recovery phase; (4) to perform the direct control of monopoly through the control of the difference between the market and “natural” (competitive) prices. This control could be realized permanently, actually in “on-line” mode. As compared to indirect methods (which are discrete ones), the price control does not require the confidential information of a firm’s activity, which is often unavailable for the regulator.
JEL classіfіcatіon: D40, D41, D42, D43
Consumer expenditures and problems of savings of economic subjects in the conditions of economic shocks – behavioral aspects
Authors: Synytsya Maksym 
Published: December 2022

The purpose of the article is to reveal the main reasons for the low level of savings, investments and excessive consumer lending and opportunities for improving financial well-being at the micro level and forming sources for future development. The article reveals the main problems of citizens’ savings and consumption that occurred before the crisis caused by the coronavirus pandemic. And which only intensified during it. Some macroeconomic indicators reflecting the state of citizens’ savings and dependence on income were analyzed. Despite the stable growth of the population’s income, the savings rate remains at a low level. On the other hand, the demand for loan funds is ahead of such growth. In this way, the thesis about the negative relationship between wage growth and the rate of savings, put forward by some scientists earlier, was proved. Regardless of the presence of economic factors affecting the level of consumption and savings, the psychological reasons for the low tendency of citizens to save were also analyzed. Among these reasons are the deficit thinking effect, the default effect, confirmation bias, and loss aversion bias. It was also analyzed based on the facts, how much the psychological prejudices of Ukrainians influenced financial behavior. In particular, the fallacy of prejudices regarding the impracticality of investing in deposits of Ukrainian banks, as well as the idea that the Ukrainian banking system underwent catastrophic transformations in the first years after the banking reform, was considered.The research methods are descriptive, analytical, methods of synthesis and comparison. As a result of the analysis, the article proposes a comprehensive approach to men’s behaviour toward savings during the pandemic according to behavioural economics.Consideration of the economic and psychological aspects of the situation with savings led to the provision of conclusions and proposals. The main task for improving the effectiveness of managing one’s own expenses today is to understand the reasons for irrational behavior of people in new circumstances from the point of view of behavioral economics and the application of the theory of “pushing” for the formation of positive socio-economic changes. It is suggested to use this paper for further and deeper practical research of certain aspects of changing people’s behaviour for better investment solutions and financial wellbeing.
JEL classіfіcatіon: D14, D91, E21
Working with mathematically gifted students
Authors: Gogovska Valentina , Anevska Katerina , Malcheski Risto 
Published: December 2022

Working with gifted students is of special social interest. However, in the existing secondary education curricula, it is only declaratively mentioned and this important segment of the education system is completely neglected. That is why in this paper an attempt was made to develop a program for work with mathematically gifted students aged 17–18, that is, for the third year of secondary education, using the concentric circle method. This study uses a descriptive method and gives examples of contents for the curriculum for working with gifted students. Curriculum materials were prepared using the method of concentric circles, which means that some contents adopted in previous years at a certain level are extended and expanded. The study draws from resources from previous researchers and existing literature.
Keywords: Concentric circle; curricula; gifted students; mathematics.
Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis
Authors: Istaufa Fikriaddin Syafiq , Subagio Yoyok , Suswati Irma , Isbandiyah  
Published: December 2022

Highlight :

Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015.
Castor plant leaf extract (Ricinus communis L.) has an antibacterial potential against the growth of Mycobacterium tuberculosis bacteria.

Abstract:
Mycobacterium tuberculosis is the cause of pulmonary tuberculosis that can reduce human health. In the therapy of the disease, patients can develop resistance to tuberculosis drugs. Based on the 2015 health profiles of Indonesia, 15,380 people were suspected to have multidrug-resistant tuberculosis (MDR-TB), while 1,860 people were confirmed patients with MDR-TB. There is a need for innovation to develop the latest treatments using natural ingredients, one of which is castor plant (Ricinus communis L.) that contains antibacterial compounds against Mycobacterium tuberculosis. This study aimed to understand the antimicrobial potential of castor plant (Ricinus communis L.) leaf extract against the growth of Mycobacterium tuberculosis. This scientific paper was a quantitative systematic review study. Literature in the form of journal articles and books were obtained through search engines, i.e. ebook database, Google Scholar, Cochrane, Wiley, and PubMed. The results of the literature source search were 19 journal articles and 4 ebooks, as well as 4 journal articles that were in accordance with the title of this literature review and discussed the effects of castor plants on the growth of Mycobacterium tuberculosis. The results of the analysis showed that castor plant (Ricinus communis L.) leaf extract has the potential in the antibacterial activity against the growth of Mycobacterium tuberculosis because it contains phytochemicals in the form of flavonoids, saponins, alkaloids, tannins, and fatty acid amides derived from ricinoleic acid as the main constituent of castor plants (Ricinus communis L.). There is antimicrobial potential for castor plant (Ricinus communis L.) leaf extract against the growth of Mycobacterium tuberculosis.
Healing in Nurses After Assignment in Natural Disasters
Authors: Solikhah Fitriana Kurniasari , Aditya Ronal Surya 
Published: December 2022

Highlight :

Disasters impact a large number of people, including nurses who are deployed in the disaster relief.
Culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit have implications in pushing the nurses to overcome their trauma and obstacles.
Government policies are also important in helping nurses to heal after deployment in disaster relief.

Abstract :
Disasters are defined as catastrophic occurrences that impact a large number of people quickly and with an abrupt onset. On average, one natural disaster is reported globally each day. However, the impact of a traumatic occurrence on an individual may be compared to a rock colliding with the surface of a water body. Systematic searches were conducted in Cochrane, Google Scholar, PubMed, Scopus, Embase, and Web of Science databases. The following keywords were used to perform a literature search: "nurse," "healing," and "natural catastrophes". As a result of reviewing 362 abstracts and titles, ten were determined to meet the study goals. The research methods in four of the ten literatures were qualitative, five quantitative, and one was a blend of both. Generally, culturally appropriate psychological first aid sessions, post-natural disaster assignment monitoring, and grit push people to overcome obstacles and accomplish achievements over time. Nurses who have been deployed to natural catastrophes must heal and need time to rest physically and mentally. This study aimed to find out the implications of culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit in pushing individuals to overcome obstacles and achieve success over time; and how the government policies relate to trauma recovery.
A Model of Performance Evaluation for Healthcare Workers Based on Satisfaction and Remuneration (Financial and Non-Financial)
Authors: Wahyuhadi Joni , Hidayah Nur , Qurratul Aini  
Published: December 2022

Highlights:

This study aimed to formulate an evaluation model of the performance of health workers.

Employee performance targets and employee satisfaction were assessed by considering the financial and non-financial remuneration, Job Description Index (JDI), competencies, and motivation.

The performance evaluation model for health workers shows the importance of remuneration for government agencies, employees, and employee performance.

Abstract:
This study aimed to formulate an evaluation model of the performance of health workers from the perspective of financial and non-financial satisfaction and remuneration. The research method used was a literature study with a literature review approach. The research findings were the healthcare workers' performance evaluation model based on satisfaction and remuneration. The evaluation was conducted by assessing the employee performance targets (sasaran kerja pegawai/SKP) and employee satisfaction related to the financial and non-financial remuneration, Job Description Index (JDI), competencies, and motivation. In addition, this model has been also used for the evaluation of performance appraisal based on remuneration among employees (i.e. health workers) in government agencies, especially hospitals.
Analisis Pengaruh Kinerja Keuangan Terhadap Harga Saham (Studi Pada Perusahaan Sub Sektor Farmasi Yang Terdaftar Di Bursa Efek Indonesia Tahun 2014 – 2018)
Authors: Satrio Jati , Suhaili Achmad 
Published: December 2022

ABSTRACT In this study, the aim is to obtain evidance regarding the analysis of the effect of finansial performance on stock prices. The independent variable used in this study is Current Ratio, Return on Equity, Debt to Equity Ratio and Total Assets Turnover. While the dependent variable used in this study is the share price measured using Moving Average 200 (MA200).The population in this study is all pharmaceutical sub-sector manufacturing companies that have been listed on the Indonesia Stock Exchange in the 2014 – 2018 period. In determining the sample of this study using the purposive sampling method and has obtained a sample of 7 pharmaceutical sub-sector manufacturing companies based on predermined criteria. The analysis technique used in this study isu sing multiple regression analysis through SPSS version 26.The result of this study indicate that: (1) Current Ratio has no influence on stock prices, (2) Return on Equity has a positive and significant effect on stock prices, (3) Debt to Equity Ratio has no influence on stock prices, (4) Total Assets Turnover has a positive and significant effect on stock prices. Keywords: Stock Price, Current Ratio, Return on Equity, Debt to Equity Ratio and Total Assets Turnover
SIKAP DAN TANGGAPAN MASYARAKAT DESA TAMPANG AWANG KABUPATEN BANJAR TERHADAP KEGIATAN PENYULUHAN DAN PEMBIMBINGAN PENYADAPAN NIRA DAN PENGOLAHAN BUAH NIPAH SEBAGAI BAHAN PANGAN
Authors: Radam Rosidah , Kanti Rina , Rahmiyati Rahmiyati 
Published: December 2022

Sikap merupakan kesiapan untuk bereaksi terhadap suatu objek dengan cara-cara tertentu. apabila, individu dihadapkan pada stimulus yang harus direspon. Tujuan penelitian ini adalah Mengukur sikap dan tanggapan masyarakat kelompok tani “Tani Makmur Jaya “terhadap kegiatan Pengabdian Kepada Masyarakat yang dilakukan. Metode yang digunakan dalam pengumpulan data dengan cara wawancara langsung dengan menggunakan kuesioner terstruktur danpengamatan langsung untuk mengukur keterampilan responden. Pengambilan sampel dengan teknik Purpossive Random Sampling terhadap 26 orang responden. Parameter yang diamati adalah kegiatan penyuluhan/sosialisasi, pelatihan pengolahan buah nipah menjadi olahan makanan dan campuran minuman. Pelatihan dan dan pembimbingan pemanfaatan tumbuhan nipah sebagai bahan pangan. Hasil penelitian menunjukkan bahwa Sikap dan tanggapan masyarakat terhadap kegiatan pengabdian menunjukkan 100% masyarakat memahami isi materi penyuluhan, pada kegiatan demontrasi pengolahan buah nipah menjadi olahan makanan 65 % memahami dan akan mencoba mengolah buah nipah sebagai bahan pangan, dan pada demontrasi pembimbingan prasadap dan penyadapan nira nipah 75% memahami dan akan mencoba, dan 25 % hanya menyaksikan proses pradasap dan penyadapan