bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Peranan Ibu Dalam Pemeliharaan Kesehatan Gigi Mulut Terhadap Angka Kebersihan Gigi Anak Tk Bhakti Nurush Shofia Mutih Kulon Wilayah Puskesmas Wedung 2 Kabupaten Demak
Authors: Santoso Bedjo , Sulistiyowati Indiyah , Mustofa Yodong 
Published: January 2022

ABSTRACTThe dental health problems of preschool children are dental caries and tooth-supporting tissue disease, one of which causes is an external factor that is the role of parents that is indispensable in guiding, understanding, reminding, and providing facilities to children so that children can maintain cleanliness teeth and mouth. This study aims to analyze the relationship between the role of mothers in maintaining oral health and dental hygiene rates for the children of Bhakti Nurush Shofia Mutih Kulon Kindergarten in the area of Puskesmas Wedung 2, Demak Regency. This type of research is the analytic with approach cross-sectional. The population of 108 consists of 54 mothers and 54 pre-school children. Samples were taken 30% of the total population so that 30 people were consisting of 15 mothers and 15 children. The results of the validity test of the instrument with the product-moment obtained values between 0.457 - 0.727 meaning that 20 items were valid. Instrument reliability was tested using Cronbach's alpha with a result of 0.901 which means 20 reliable question items. Results The role of parents was mostly included in the medium category at 66.7%. The plaque index of children who had both good and moderate categories was 40.0%, fewer categories were 20.0%. statistical test results Spearmen rank to show that p-value 0.001, meaning that there is a significant relationship between the role of mothers in maintaining oral health with plaque index. Children
HUBUNGAN MENGKONSUMSI SOFTDRINK TERHADAP KEASAMAN PH SALIVA PADA SISWA/ I SMAN 13 BANDAR LAMPUNG TAHUN 2020
Authors: Andriyani Desi 
Published: January 2022

Derajat keasaman (pH) Saliva dipengaruhi oleh banyak faktor, salah satunya adalah adanya rangsangan (stimulasi). Stimulasi ini dapat berupa rangsangan dari rasa manis dan asam merupakan minuman yang banyak dikonsumsi oleh masyarakat, karena mudah didapatkan dan rasa yang manis juga menyegarkan tanpa mengetahui dampak dari minuman bersoda dan isotonik terhadap rongga mulut (Coombes, 2005). Penelitian ini bertujuan untuk mengetahui apakah ada Hubungan mengkonsusmsi Softdrink terhadap keasaman PH Saliva pada Siswa/I SMAN 13 Bandar Lampung. Jenis penelitian yang digunakan adalah analitik observasi, rancangan atau desain dalam penelitian ini menggunakan pendekatan cross sectional. Adapun cara pengambilan sampel dengan menggunakan teknik Quota sampling, sebanyak 75 siswa/siswi SMAN 13 Bandar Lampung penelitian dengan menggunakan kertas lakmus untuk mengetahui kriteria asam dan basa. Hasil penelitian yang didapat dari 75 sampel yang mengkonsumsi Softdrink sebanyak, Softdrink Fanta 20 orang (26,67%), Sprite 34 orang (45,33%), Coca-cola 18 orang (24%) merek lain 3 orang (4%). Uji chi Square untuk pH Saliva terhadap macam-macam softdrink yang dikonsumsi didapatkan p-value sebesar 0,01, karena p-value (0,05) Artinya minuman softdrink dapat menurunkan derajat keasaman pH Saliva.
Asuhan Kesehatan Gigi Dan Mulut Pada Pasien Skizofrenia Di Ruang Rawat Inap RS Jiwa Daerah Provinsi Jambi
Authors: Boy Hendry , Veriza Veriza , Valentina Valentina 
Published: January 2022

Pasien skizofrenia merupakan ganguan jiwa dengan resiko karies dan penyakit periodontal yang tinggi. Kondisi kesehatan gigi dan mulut pasien skizofrenia yang buruk disebabkan kondisi mental pasien itu sendiri, penggunaan obat anti anxiety dan obat penenang lainnya, kurangnya fasilitas kesehatan gigi, pengetahuan kesehatan gigi dan mulut yang minim, kemampuan serta kurangnya pendampingan dari tenaga kesehatan. Tujuan dari penelitian ini adalah untuk mengembangkan model asuhan kesehatan gigi dan mulut untuk pasien skizofrenia di ruang rawat inap Rumah Sakit Jiwa Daerah Provinsi Jambi.Rancangan penelitian ini adalah penelitian terapan, metode kualitatif dengan pengambilan sample dengan teknik purposive sampling dengan jumlah sampel berdasarkan kesesuaian dan kecukupan.Hasil penelitian menunjukan bahwa memungkinkan untuk melakukan asuhan kesehatan gigi dan mulut pada pasien skizofrenia di ruaang rawat inap Rumah Sakit Jiwa Daerah Provinsi Jambi oleh terapis gigi yang bertugas di ruang rawat inap. Asuhan berupa kegiatan promotif dengan penyuluhan, kegiatan preventive melakukan menyikat gigi, dan tindakan konsul ke poli gigi dapat dilakukan
Evaluasi Pembelajaran Daring Masa Pandemi Covid-19 Melalui Penerapan Aplikasi Ujian Berbasis Komputer (CBT) oleh Dosen Jurusan Keperawatan Gigi Poltekkes Kemenkes Semarang Tahun Akademik 2020/2021
Authors: Sukendro Sulur Joyo , Wiyatini Tri , Wiradona Irmanita 
Published: January 2022

Education is to change behavior for the better. The period of new norm, learning process most activities are carried out independently from home using e-learning. E-learning is an educational system or concept that utilizes information technology in the teaching and learning process. To measure the success of the teaching and learning process, application camputer base test (CBT) is needed that can be applied remotely.Method community dedication is the application of the results of the research prototype application analysis of the final exam for the even semester of the Konsep Dasar Pelayanan Asuhan Kesehatan Gigi dan Mulut for the 2019/2020 based on validity, reliability, differentiation, difficulty level, and deceptive effectiveness. The results have been proven in research by Lecturers of the Department of Dental Health at Health Polytechnic Semarang and are sustanable for use. The target of this community service is the lecturers and students of the the Department of Dental Health at Health Polytechnic Semarang in the even 2020/2021.The result of community dedication was a redesign of the application camputer base test (CBT) in collaboration with monev.co. The next step by sosialization about computer-based test (CBT) and tested for students of the D III Dental Health Study Program and the D IV Dental Therapy Study Program. Responses from students felt helped by the application used because it can be used other than on a laptop / PC but can be used on an Android Phone cell; can bring up the work timer timer; marking questions when in doubt; there is a temporary save feature which helps when the internet connection is lost; the results / test scores can be found some time after the exam is over. Whereas Lecturers are helped because of the monitoring menu for students who take exams; start opening the application; start doing exam questions; completion of the exam and the menu for correcting student exam questions and publication of grades. The reports generated from the computer-based exam / computer base test (CBT) application are validity, reliability, differentiation, difficulty level, and distractor effectiveness of the questions used.The conclusion of this community dedication is a computer-based test (CBT) in collaboration with monev.co which can be used to measure the success of the online teaching and learning process for students in the Department of Dental Health at Health Polytechnic Semarang during the new norm. Suggestions from the results of this community service is an integration menu about vignete which has been declared good with the web https://www.sims-nakes.org/banksoal-diknakes.
HUBUNGAN ANTARA KARAKTERISTIK INDIVIDU DENGAN KELUHAN MUSKULOSKELETAL PETUGAS KESEHATAN GIGI DI PUSKESMAS KOTA TASIKMALAYA
Authors: Budiarti Erina , Kamelia Emma , Nugroho Cahyo 
Published: January 2022

Gangguan musculoskeletal adalah sebuah cedera yang mempengaruhi gerakan sistem tubuh manusia seperti otot, tendon, ligamen, saraf, pembuluh darah dan lainnya. Keluhan muskuloskeletal adalah keluhan pada bagian-bagian otot rangka yang dirasakan oleh seseorang mulai dari keluhan ringan sampai sangat sakit, apabila otot menerima beban statis secara berulang dalam waktu yang lama akan dapat menyebabkan keluhan berupa kerusakan pada sendi, ligamen, dan tendon. Terapis gigi dan mulut yang bekerja di Puskesmas Kota Tasikmalaya mayoritas mengalami keluhan muskuloskeletal (90,20%), rata-rata keluhan yang dirasakan pada tubuh bagian bahu kanan, punggung, lengan atas kanan, pinggang, leher bagian atas dan bawah. Tujuan: Mengetahui hubungan antara karakteristik individu dengan keluhan muskuloskeletal petugas kesehatan gigi dan mulut di Puskesmas Kota Tasikmalaya. Metode Penelitian: Jenis penelitian non experimental dengan rancangan cross sectional, populasi penelitian seluruh terapis gigi dan mulut di Puskesmas Kota Tasikmalaya berjumlah 53 orang, semua terapis gigi dan mulut menjadi sampel penelitian. Data primer diambil secara langsung menggunakan kuesioner lembar identitas dan Nordic Body Map. Variabel independent: karakteristik individu, variabel dependent: keluhan muskuloskeletal. Hasil: Didapatkan nilai p value 0,05. Kesimpulan: Berdasarkan uji korelasi rank spearman, tidak terdapat hubungan antara karakteristik individu dengan keluhan muskuloskeletal petugas kesehatan gigi dan mulut di Puskesmas Kota Tasikmalaya.
Neutrophil-to-Lymphocyte Ratio (NLR) as An Inflammation Degree Marker in Tongue Cancer Patient
Authors: Lathifah Syakira Husna , Yohana Winny , Rodian Moch. 
Published: January 2022

Tongue cancer is one of the most common malignancies of all oral malignancies. Cancer staging is induced by a systemic inflammatory response with one of the markers, one of them is neutrophil-lymphocyte ratio (NLR). This study aims to provide an overview of the NLR as a marker of the degree of inflammation in patients with tongue cancer. This systematic literature review was conducted online from January 2021 to March 2021 against articles reporting RNL as a marker of inflammatory action in patients with tongue cancer. The search for articles referred to Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) and conducted through PubMed, PMC, ScienceDirect, and EBSCOhost with the publication year 2015-2020. Selected articles met the criteria according to the PICO framework (Population, Intervention, Comparison, Outcome). Article screening is done by reading the title and abstract, checking for duplication, and reading the entire text. Sixteen in 841 research articles with observational study design were identified, the NLR cut-off value ranges from 2.04-2.95. Nine in ten research articles suggested a relationship between the NLR value and several clinicopathological characteristics of the patient. Twelve articles mentioned that there was the association of RNL with patient overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS). The NLR value can be an indicator of the degree of inflammation in patients with tongue cancer as assessed from the parameters of the clinicopathological assessment and can be a predictive factor for patient's prognosis or survival status.
Acceptability Test and Glucose Analysis of Non-Cariogenic Biscuit Based On Sorghum Flour and Xylitol Sugar
Authors: Subekti Ani , Siregar Irma H.Y , Sunarjo Lanny 
Published: January 2022

Kasus karies gigi banyak ditemukan pada usia tumbuh kembang yaitu anak-anak prasekolah dan usia sekolah. Anak prasekolah dan sekolah sering mengkonsumsi jajanan makanan kariogenik yang menjadi salah satu penyebab terjadinya karies. Makanan kariogenik adalah makanan yang banyak mengandung glukosa dan bersifat lengket di gigi geligi. Anak-anak sangat suka dengan jajanan berupa biskuit yang manis. Tujuan dari penelitian ini adalah mengetahui uji analisa kandungan glukosa dan uji organoleptik pada biskuit nonkariogenik berbahan dasar shorgum terkandung gula xilitol.Jenis penelitian adalah eksperimen dengan 3 kelompok perlakuan dan 1 kelompok kontrol. Pengujian analisis meliputi uji organoleptik dan uji Luff scrool. Pengujian menggunakan metode hedonic scale test dengan analisa secara deskriptif kuantitatif.Hasil kandungan glukosa pada Biskuit xilitol 50% adalah yang paling rendah 2,38%. Namun anak-anak paling tidak menyukai biskuit sorgum. Kesimpulan penelitian ini adalah biskuit xilitol 100% disukai oleh anak-anak. Uji organoleptik menunjukkan anak-anak menyukai biskuit xilitol 100% karena faktor rasa, aroma, mudah dikunyah, mudah digigit dan mudah ditelan dibandingkan dengan biskuit sorgum dan biskuit xilitol 50%.
STUDY REGARDING ETHICAL VERSUS GENERIC PRESCRIPTION OF STATINS
Authors: Atwal Shilpa , Thakur Jitender 
Published: January 2022

Background: To study the ethical versus generic prescription of statins
Methods: Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.
Results: In our study population, amongst the primary prevention group, a larger percentage about 56% were receiving generic prescription of statins and about 44% were receiving ethical prescription of statins .Whereas in secondary prevention group, about 45.5% of patients were receiving generic prescription and 54.5% were receiving ethical prescription .
Concluded: In our study population patients were equally prescribed on ethical (49.8%) and generic prescriptions (50.2%).
Keywords: Statin, Ethical, Generic
Livestock and environment
Authors: Ibragimov A. G. , Borulko V. G. , Lukyanova I. А. 
Published: January 2022

Relevance.With the development of the application of the achievements of scientific and technological progress in agricultural production, agriculture began to take more from nature, and instead throw in there a huge amount of waste generated as a result of activities. Therefore, the problem of environmental protection in agricultural production, especially in industrial animal husbandry, has become urgent. Livestock and poultry farming with their manure, dung, greenhouse gases and other wastes have begun to pollute the environment more. These pollutants reduce soil fertility and productivity, and deteriorate the quality of water and atmospheric air. As a result, agricultural production itself suffers, agricultural products are received in less amount and the quality of products deteriorates.Materials and research methods.The material of the study was the data of environmental statistical reporting of the Russian Federation and its subjects over the last 10 years, as well as materials of periodical scientific publications on environmental problems. In the course of the research, abstract-logical, monographic, computational-constructive, comparative analyzes and statistical methods were used.Results.According to the state reports “On the state and protection of the environment of the Russian Federation”, the agro-industrial complex in modern conditions continues to be the main pollutant of land and other elements of the environment. More than 45 types of pollutants are emitted into the environment from livestock farms and complexes and poultry farms. Atmosphere air is contaminated with microorganisms, dust, ammonia and other animal waste products. Large volumes of manure and droppings generated in the course of the activity of livestock enterprises, the complexity of their processing and disposal indicate the need to use a variety of ways to solve the problem of effective treatment of manure and droppings. In this sense, the chinese waste disposal technology is of particular interest. China is now took the leading positions in the world in the biological disposal of food and agricultural waste with the help of black lion fly larvae.
Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary
Authors: Song Yanlong , Chen Weiting , Zhu Bo , Ge Wei 
Published: January 2022

Folliculogenesis is controlled by intimate communications between oocytes and surrounding follicle cells. Epidermal growth factor (EGF/Egf) is an important paracrine/autocrine factor in vertebrate ovary, and it is well known for its stimulation of oocyte maturation. However, the role of EGF signaling through its receptor (EGFR/Egfr) in ovarian folliculogenesis is poorly understood, especially at early stages of follicle development. In this study, we created zebrafish mutants for Egf (egf−/−) and Egfr (egfra−/− and egfrb−/−) by CRISPR/Cas9 technique. Surprisingly, these mutants all survived well with little abnormality in growth and development. Spermatogenesis and folliculogenesis were both normal in egf−/− males and females. Their fecundity was comparable to that of the wildtype fish at 4 months post-fertilization (mpf); however, the fertilization rate of mutant eggs (egf−/−) decreased significantly at 7 mpf. Interestingly, disruption of egfra (egfra−/−) led to failed follicle activation with folliculogenesis being blocked at primary–secondary growth transition (PG-SG transition), leading to female infertility, whereas the mutant males remained fertile. The mutant ovary (egfra−/−) showed abnormal expression of a substantial number of genes involved in oxidative metabolism, gene transcription, cytomembrane transport, steroid hormone biosynthesis, and immune response. The stunted PG oocytes in egfra−/− ovary eventually underwent degeneration after 6 months followed by sex reversal to males with functional testes. No abnormal phenotypes were found in the mutant of truncated form of EGFR (egfrb). In summary, our data revealed critical roles for EGFR signaling in early folliculogenesis, especially at the PG-SG transition or follicle activation.
New Chitosan Polymer Scaffold Schiff Bases as Potential Cytotoxic Activity: Synthesis, Molecular Docking, and Physiochemical Characterization
Authors: Packialakshmi Ponnusamy , Gobinath Perumal , Ali Daoud , Alarifi Saud , Gurusamy Raman , Idhayadhulla Akbar , Surendrakumar Radhakrishnan 
Published: January 2022

In this work, we synthesize the sulfonated Schiff bases of the chitosan derivatives 2a-2j without the use of a catalyst in two moderately straightforward steps with good yield within a short reaction time. The morphology and chemical structure of chitosan derivatives were investigated using FT-IR, NMR (1H—13C), XRD, and SEM. Furthermore, our chitosan derivatives were tested for their anticancer activity against the MCF-7 cancer cell line, and doxorubicin was used as a standard. In addition, the normal cell lines of the breast cancer cell MCF-10A, and of the lung cell MRC-5 were tested. Compound 2 h, with a GI50 value of 0.02 µM for MCF-7, is highly active compared with the standard doxorubicin and other compounds. The synthesized compounds 2a-2j exhibit low cytotoxicity, with IC50 &gt; 100 μg/ml, against normal cell lines MCF-10A, MRC-5. We also provide the results of an in-silico study involving the Methoxsalen protein (1Z11). Compound 2h exhibits a higher binding affinity for 1Z11 protein (−5.9 kcal/mol) and a lower binding affinity for Doxorubicin (−5.3 kcal/mol) than certain other compounds. As a result of the aforementioned findings, the use of compound 2h has an anticancer drug will be researched in the future.
Application of Fatty Liver Inhibition of Progression Algorithm and Steatosis, Activity, and Fibrosis Score to Assess the Impact of Non-Alcoholic Fatty Liver on Untreated Chronic Hepatitis B Patients
Authors: Huang Yan , Gan Qinyi , Lai Rongtao , Wang Weijing , Guo Simin , Sheng Zike , Chen Lu , Guo Qing , Cai Wei , Wang Hui , Zhao Gangde , Cao Zhujun , Xie Qing 
Published: January 2022

Backgrounds and PurposeConcurrent non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is a frequent and increasingly concerning problem because of the NAFLD pandemic. Admittedly, NAFLD can progress to non-alcoholic steatohepatitis (NASH) and severe fibrosis. Direct evidence of the fibrotic effect of NAFLD or NASH in chronic hepatitis B virus (HBV) infection remains lacking. We aimed to reveal the influence of concurrent histologically proven fatty liver diseases in fibrogenesis with chronic HBV infection.MethodsWe performed a retrospective cross-sectional study on a liver biopsy population of CHB patients without excessive alcohol intake to evaluate the prevalence of concurrent histologically proven NAFLD or NASH according to the fatty liver inhibition of progression (FLIP) algorithm and its association with the liver fibrosis stage.ResultsAmong 1,081 CHB patients, concurrent NAFLD was found in 404 patients (37.4%), among whom 24.0% (97/404) have NASH. The presence of NASH was an independent predictor of significant fibrosis (odds ratio (OR), 2.53; 95% CI, 1.52–4.21; p &lt; 0.001) and severe fibrosis (OR, 1.83; 95% CI, 1.09–3.09; p = 0.023) in all patients, as well as in patients with normal alanine aminotransferase (ALT) (predicting significant fibrosis, OR, 2.86, 95% CI, 1.34–6.10; p = 0.007). The presence of lobular inflammation (p &lt; 0.001) or presence of cytological ballooning (p &lt; 0.001), rather than presence of steatosis (p = 0.419), was related with severity of fibrosis in Spearman’s correlation analysis.ConclusionsConcurrent NAFLD is common in CHB patients, and NASH is an independent risk factor potentiating significant fibrosis by 2.53-fold and severe fibrosis by 1.83-fold. While coping with chronic HBV infection, routine assessment of co-existing NAFLD or NASH is also important.
Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy
Authors: Xi Shaosong , Wang Yunguang , Wu Chenghao , Peng Weihua , Zhu Ying , Hu Wei 
Published: January 2022

BackgroundGut–microbiota–brain axis links the relationship between intestinal microbiota and sepsis-associated encephalopathy (SAE). However, the key mediators between them remain unclear.MethodsMemory test was determined by Water maze. Intestinal flora was measured by 16S RNA sequencing. Neurotransmitter was detected by high-performance liquid chromatography (HPLC). Histopathology was determined by H&amp;E, immunofluorescence (IF), and terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) staining. Flow cytometry was employed to determine the proportion of macrophages.ResultsFecal microbiota transplantation (FMT) relieved hippocampus impairment of SAE rats by inhibiting inflammation cytokine secretion, the expression of IBA-1 and neurotransmitter disturbance, and cell apoptosis and autophagy, accompanied by the reduced M1 polarization and M1 pro-inflammation factors produced by macrophages in mesenteric lymph nodes (MLNs). Actually, M1 polarization in SAE rats depended on intestinal epithelial cell (IEC)-derived exosome. GW4869-initiated inhibition of exosome secretion notably abolished M1 polarization and the secretion of IL-1β. However, GW4869-mediated improvement of hippocampus impairment was counteracted by the delivery of recombinant interleukin (IL)-1β to hippocampus. Mechanistically, IEC-derived exosome induced the excessive circulating IL-1β produced by CP-R048 macrophages, which subsequently induced damage and apoptosis of hippocampal neurons H19-7 in an autophagy-dependent manner. And reactivation of autophagy facilitates intestinal IL-1β-mediated hippocampal neuron injury.ConclusionCollectively, intestinal flora disturbance induced the exosome release of IECs, which subsequently caused M1 polarization in MLNs and the accumulation of circulating IL-1β. Circulating IL-1β promoted the damage and apoptosis of neurons in an autophagy-dependent manner. Possibly, targeting intestinal flora or IEC-derived exosome contributes to the treatment of SAE.