bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial.
Authors: Schwab Claire , Cranston Ruth , Ryan Sarra , Butler Ellie , Winterman Emily , Hawking Zoe , Bashton Matthew , Enshaei Amir , Russell Lisa , Kingsbury Zoya , Peden John , Barretta Emilio , Murray James , Gibson Jude , Hinchliffe Andrew , Bain Robert , Vora Ajay , Bentley David , Ross Mark , Moorman Anthony , Harrison Christine 
Published: October 2022

Abstract
Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about 30% B-ALL (B-other-ALL) without well-established chromosomal changes, new genetic subtypes have recently emerged, yet their true prognostic relevance largely remains unclear. We integrated next generation sequencing (NGS): whole genome sequencing (WGS) (n = 157) and bespoke targeted NGS (t-NGS) (n = 175) (overlap n = 36), with existing genetic annotation in a representative cohort of 351 B-other-ALL patients from the childhood ALL trail, UKALL2003. PAX5alt was most frequently observed (n = 91), whereas PAX5 P80R mutations (n = 11) defined a distinct PAX5 subtype. DUX4-r subtype (n = 80) was defined by DUX4 rearrangements and/or ERG deletions. These patients had a low relapse rate and excellent survival. ETV6::RUNX1-like subtype (n = 21) was characterised by multiple abnormalities of ETV6 and IKZF1, with no reported relapses or deaths, indicating their excellent prognosis in this trial. An inferior outcome for patients with ABL-class fusions (n = 25) was confirmed. Integration of NGS into genomic profiling of B-other-ALL within a single childhood ALL trial, UKALL2003, has shown the added clinical value of NGS-based approaches, through improved accuracy in detection and classification into the range of risk stratifying genetic subtypes, while validating their prognostic significance.
Comparison of the Effect of Pan-Retinal Photocoagulation versus Intravitreal Anti-vascular Endothelial Growth Factor Injection on the Foveal Vasculature Using Optical Coherence Tomography Angiography
Authors: Riazi-Esfahani Hamid , Ahmadi Amin , Sadeghi Reza , Mirghorbani Masoud , Ghassemi Fariba , Zarei Mohammad , Khojasteh Hassan , Faghihi Hooshang , Pour Elias Khalili , Mirshahi Ahmad , Bayan Nikoo 
Published: October 2022

AbstractIntroduction:To evaluate and compare macular vasculature changes in 1 and 3-months after initiating treatment with either panretinal photocoagulation (PRP) or Intravitreal bevacizumab (IVB) injection.Methods: A total of 62 eyes from 33 diabetic patients without macular edema were included in this prospective case series. Of these, thirty-nine eyes (21 patients) were allocated to the PRP group, while 23 eyes (12 patients) were treated with IVB biosimilar (Stivantâ). Optical tomography angiography (OCTA) was performed to measure foveal avascular zone (FAZ) characteristics as well as superficial (SCP) and deep vascular plexus (DCP) densities.Results: After the initiation of IVB injections, the FAZ area and Perimeter expanded modestly at month 1 but returned to baseline level after three months. In the PRP group, however, FAZ area and Perimeter were rather steady. FAZ area changes were significantly different between treatment groups at month 1 (p=0.02), but not at month 3 (p=0.31). The comparison of two groups based on mean FAZ perimeter change revealed a significant difference at month 1, but no significant difference at month 3 (p=0.03 and p=0.48, respectively). There was no significant difference in the FAZ circularity index change between the two groups at each timepoints (p=0.55 and p=0.31). The foveal vessel density changes in the SCP were not statistically significant between the two groups, at both month 1 and 3 (all P>0.05). A comparison of two treatment arms based on mean DCP density change revealed a significant difference at month 1, but not at month 3 (p=0.01 and p=0.49, respectively).Conclusion: Some vascular metrics changes in OCTA (e.g., FAZ area, Perim, Foveal DCP vascular density) may be significantly different between two types of therapies in the very early short-term (1 month) after treatment initiation. In the third month following treatment, all of these differences diminished to insignificance.
Simulation of inertial droplet dispersion and the spray mediated fluxes in the atmospheric boundary layer above waved water surface: a Lagrangian stochastic model versus direct numerical simulation
Authors: Troitskaya Yuliya , Druzhinin Oleg , Gladskikh Daria , Ermakova Olga , Soustova Irina 
Published: October 2022

Abstract
Lagrangian stochastic models (LSM) are widely used to model the dispersion of sea spray droplets injected from the water surface into the marine atmospheric boundary layer (MABL) and for evaluation of the spray impact on the exchange fluxes between the atmosphere and the ocean. While moving through the MABL the droplets pass through the region of high gradients of air velocity, temperature and humidity occurring in the vicinity of the air-water interface. In this case, the applicability of LSMs constructed under the assumption of weakly inhomogeneous flows is questionable. In this work, we develop a Lagrangian stochastic model taking into account the strongly inhomogeneous structure of the airflow in MABL and, in particular, the anisotropy of turbulence dissipation rate. The model constants and the diffusion matrix coefficients are calibrated by comparison of the LSM prediction for the profiles of droplet concentration and the exchange fluxes of sensible and latent heat against the results of direct numerical simulation (DNS) of turbulent, droplet-laden airflow over a waved water surface.
Igloo-technique for robotic radical prostatectomy—maximum nerve sparing for very early recovery of continence and sexual function
Authors: Fankhauser Christian Daniel , Malkmus Christian , Aschwanden Fabian Joel , Baumeister Philipp , Mattei Agostino 
Published: October 2022

Abstract
Background: We describe a surgical technique to facilitate very early return of continence and erectile function after robotic-assisted radical prostatectomy (RARP) for prostate cancer.
Objective: To describe the “igloo technique” for RARP.
Design, setting, and participants: Prospective study of the first 13 patients to be treated with the igloo technique at a major urban hospital. Only patients without suspected invasion of the neurovascular bundle were included.
Surgical procedure: RARP was performed using “igloo technique” to preserve all periprostatic structures, including the puboprostatic ligament complex, neurovascular bundles, Santorini complex, endopelvic and periprostatic fascia, and accessory pudendal arteries.
Outcome measurements and statistical analysis: Descriptive analysis of the perioperative, pathological, and short-term oncological outcomes.
Results and limitations: The median operative time was 200 minutes [inter-quartile range (IQR): 188–210]. The transurethral catheter was removed after a median of 3 days post-RARP. In the first 24 hours after catheter removal, the median urine loss was 4g/24h[IQR: 2–10g/24h]. Ten days after surgery, 3 patients had urine loss of 10g/24h, and 10 patients had urine loss of 0g/24h. At 6 weeks after surgery, only 1 patient had urine loss of 10g/24h, and the remaining 12 patients all reported urine loss of 0g/24h. The median IIEF-15 decrease after surgery was 19[IQR: 5–36]. Positive surgical margins were reported for 4 participants(31%), and biochemical recurrence was observed in 1 subject who did not have a positive surgical margin.
Conclusions: The igloo technique is a technically demanding technique for RARP that spares most periprostatic structures with very early return of continence and erectile function after surgery. Despite case selection, a considerable proportion of participants showed a positive surgical margin.
Patient summary: Through improved preservation of the anatomical structures around the prostate, we achieved very early return of urinary continence and erectile function after surgical removal of the prostate.
The effect of cranial techniques on the heart rate variability response to psychological stress test in firefighter cadets
Authors: Wójcik Małgorzata , Siatkowski Idzi 
Published: October 2022

Abstract

Background Heart Rate Variability is a simple tool to monitor cardiovascular stress. The proper function of the cardiovascular system is a problem among firefighters. Physical activity has health benefits being correlated with psychological stress. Physically active people should be more resilient to psychological stress but this has not always been demonstrated. The aim of this study was to determine whether cranial techniques would have an effect on HRV parameters. Osteopathy in the cranial reduces stress and improves cardiovascular function. Methods Fifty-seven firefighter cadets aged 18–24 years (21.63 ± 1.41) participated in the study. All subjects had their heart rate variability measured and were randomly assigned either to the cranial techniques (CS) group with therapy performed once a week for 5 weeks) or to the control group (CO). After 5 weeks heart rate variability was measured again in both groups. Results In the Friedman test, in the CS group there was a statistically significant effect of cranial techniques on HR and LF, but not on HF; in the CO group, a statistically significant difference was observed for HR, HF and LF. In the Nemenyi test, in the CS group there was a statistically significant difference for HR and LF and in the CO group for HR, HF and LF. After applying hierarchical clustering with Euclidean measure and the complete method, dendrograms were drawn up showing similarities for HR, HF and LF values. Conclusion The cranial techniques and touch might exert a beneficial effect on HRV.
An Exploratory Factor Analysis of the Oblique Hope, Affectivity, Resiliency, and Empathy (O-HARE) Questionnaire
Authors: Wahl Kevin , Nerone Jeffrey , Weintraub Isabell 
Published: October 2022

Abstract
An exploratory factor analysis (EFA) was used to evaluate a 54-item experimental questionnaire called the Oblique Hope, Affectivity, Resiliency, and Empathy (O-HARE). The sample was N = 181 adults in the United States who had experienced mental health concerns during their lifetime. Individuals were randomly assigned to a control condition (n = 95) and experimental condition (n = 86). Three instruments were administered online: O-HARE, NEO Five-Factor Inventory, and the Personality Assessment Screener. There was no significant effect size between the two conditions (d = .212). Factor loading using a Promax principal component rotation with coefficient's suppressed (< 0.40) indicated the O-HARE had a significant KMO = 89.8, p= .001 on 12 factors. The EFA produced low factor loadings for 18 items, and a reduction to 36 items on seven factors increased the KMO = 92.3, p = .001. The four O-HARE domains had significant t-scores with p values <.001. ANOVA demonstrated a strong relationship between the NEO-FFI-3, O-HARE, and PAS subscales. The t-scores were significant, with p values <.001 on all NEO-FFI-3 dimensions and PAS subscales.
Fabrication of NaCl aqueous electrolyte electric double layer capacitor as practical device and dependence of cell performance on pore structure of activated carbon
Authors: Onodera Hideharu , Tsubota Toshiki 
Published: October 2022

Abstract
In this study, electric double layer capacitor (EDLC) cells were fabricated as laminate type by using NaCl aqueous solution, which should be relatively safe electrolyte against environments and biological objects, for the investigation of the performance from a practical point of view. The capacitance value of the cell depended on the kind of activated carbon for EDLC electrode. The capacitance values of the cell fabricated from the best activated carbon were ca. 1.45 F at 0.1-1 mA of discharging current value and at 1.2 V of charging voltage. The capacitance value should be equivalent to commercial EDLCs although the charging voltage is smaller. The relationship between the properties related to pores of activated carbon and the capacitance value was examined. The enumerated values obtained from the Dubinin-Astakhov (DA) method for the activated carbons of this study were between 1 and 2, which could indicate that the micropore distribution of the activated carbons used in this study was heterogeneous. The capacitance value was found to be strongly related to the micropore volume calculated by the DA method from the adsorption isotherm of CO2 at 298 K. That is, the micropore volume estimated from the DA method should be used as the indicator for the selection of high-performance activated carbon for electrode of EDLC containing NaCl aqueous solution electrolyte.
Detecting Seed Nodes of Information Diffusion in Online Social Networks Using a New Degree Centrality
Authors: Ganai Aaquib Hussain , Hashmy Rana 
Published: October 2022

Abstract
Information diffusion in online social networks has always some deterministic sources that are acting as the real sources of information diffusion in online social networks. This information that is getting diffused from some sources are making their ways in the formation of information cascades in online social networks .These cascades can be handled through various cascading models of information diffusion in online social networks. We in our research are going to uncover these information cascades as information dissemination trees in online social networks. If we are able to uncover a limited number of sources as limited real information generators in online social networks, we can generate a limited number of dissemination trees. Thus number of limited source nodes can be used further to handle the information diffusion cascades in online social networks using information dissemination trees.
In this paper we are going to use a unique way of degree centrality of nodes to uncover the seed nodes in limited number with deterministic algorithm. We have tested our approach on three small social network datasets. Our method gives bests results and fits its best purpose for information tree generations when compared with the ordinary information dissemination tree generation in online social networks.
Bayesian probabilistic characterization of shear wave velocity combining cone penetration test and standard penetration test
Authors: Zhai Shijie , Du Guangyin 
Published: October 2022

Abstract
The shear wave velocity Vs is of interest since it can provide information related to soil small-strain stiffness characteristics and site classification. However, it is difficult to measure Vs directly without special equipment, particularly in smaller and medium-sized projects. Thus, numerous studies are conducted on V-S correlating, and extensive research has demonstrated that cone penetration test (CPT) and standard penetration test (SPT) data have a good relationship with shear wave velocity. Due to the uncertainty of the transformation model, such Vs values calculated by the empirical equation are unsatisfactory. The purpose of the present paper is to propose a Bayesian framework for determining the probabilistic characteristics of Vs in the context of transformation uncertainty. In addition, the Bayesian framework considers both in situ test data (SPT, CPT) and prior information. Results indicate that the Bayesian framework considering two in-situ tests accurately predicts the shear wave velocity. There are several advantages of using the Bayesian method described in this study. 1. The Bayesian framework incorporates both the inherent uncertainty of the shear wave velocity and the transformation uncertainty. 2. Prior information and field data can be combined. 3. In the framework, statistical characteristics of the Vs can be ascertained from small samples of field test data.
Comparison of performance between O-RADS, IOTA Simple Rules Risk assessment and ADNEX model in the discrimination of ovarian Brenner tumors
Authors: JIANHONG SHANG , Lei Ting , Wu LiHong , Lin MeiFang , Xie Hong-Ning 
Published: October 2022

Abstract
Purpose To describe the clinical and sonographic features of ovarian benign Brenner tumor (BBT) and malignant Brenner tumor (MBT), and to compare performance of four diagnostic models in differentiating them.
Methods Fifteen patients with BBTs and nine patients with MBTs were retrospectively identified in our institution from January 2003 and December 2021. One ultrasound examiner categorized each mass according to ovarian-adnexal reporting and data system (O-RADS), International Ovarian Tumor Analysis (IOTA) Simple Rules Risk (SR-Risk) assessment and assessment of different neoplasias in the adnexa (ADNEX) models with/without CA125. Receiver operating characteristic curves were generated to compare diagnostic performance.
Results Patients with MBT had higher CA125 serum level (62.5% vs 6.7%, P=0.009) and larger maximum diameter of lesion (89mm vs 43mm, P=0.009) than did those with BBT. BBT tended to have higher prevalence of calciﬁcations (100% vs 55.6%, P=0.012) and acoustic shadowing (93.3% vs 33.3%, P=0.004), and lower color scores manifesting none or minimal flow (100.0% vs 22.2%, P<0.001). Areas under curves of O-RADS, IOTA SR-Risk and ADNEX models with/without CA125 were 0.896, 0.913, 0.892 and 0.896, respectively. There were no significant differences between them.
Conclusion BBTs are often small solid tumors with sparse color Doppler signals, which contain calciﬁcations with posterior acoustic shadowing. The most common pattern of MBT is a large multilocular-solid or solid mass with irregular tumor borders, and most were moderately or richly vascularized at color Doppler. These four models have excellent performance in distinguishing them.
Acetylphenyl-Substituted Imidazolium Salts: Synthesis, Characterization, in silico Studies and Inhibitory Properties against Some Metabolic Enzymes
Authors: Demirci Özlem , Tezcan Burcu , Demir Yeliz , Taskin-Tok Tugba , Gök Yetkin , Aktaş Aydın , Güzel Bilgehan , Gülçin İlhami 
Published: October 2022

AbstractHerein, we present how to thirteen new synthesize 1-(4-acetylphenyl)-3-alkylimidazolium salts by reacting 4-(1-H-imidazol-1-yl)acetophenone with a variety of benzyl halides that contain either electron-donating or electron-withdrawing groups. The structures of the new imidazolium salts were conformed using different spectroscopic method (1H NMR,13C NMR,19F NMR and FTIR) and elemental analysis techniques. Furthermore, the carbonic anhydrase and acetylcholinesterase enzyme inhibition activities of these compounds were investigated. They showed highly potent inhibition effect toward acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) with Kivalues in the range of 8.30±1.71 to 120.77±8.61 nM for AChE, 16.97±2.04 to 84.45±13.78 nM for hCA I, and 14.09±2.99 to 69.33±17.35 nM for hCA II, respectively. Most of the synthesized imidazolium salts were appeared to be more potent than the standard inhibitor of tacrine (TAC) against AChE, and Acetazolamide (AZA) against CA. In the meantime, to prospect for potential synthesized imidazolium salt inhibitor(s) against acetylcholinesterase (AChE) and carbonic anhydrases (hCAs), molecular docking and ADMET-based approach was exerted.
Perfect intrinsic squeezing at the superradiant phase transition critical point
Authors: Hayashida Kenji , Makihara Takuma , Peraca Nicolas Marquez , Padilla Diego Fallas , Pu Han , Kono Junichiro , Bamba Motoaki 
Published: October 2022

Abstract
Some of the most exotic properties of the quantum vacuum are predicted in ultrastrongly coupled photon–atom systems; one such property is quantum squeezing leading to suppressed quantum fluctuations of photons and atoms. This squeezing is unique because (1) it is realized in the ground state of the system and does not require external driving, and (2) the squeezing can be perfect in the sense that quantum fluctuations of certain observables are completely suppressed. Specifically, we investigate the ground state of the Dicke model, which describes atoms collectively coupled to a single photonic mode, and we found that the photon–atom fluctuation vanishes at the onset of the superradiant phase transition in the thermodynamic limit of an infinite number of atoms. Moreover, when a finite number of atoms is considered, the variance of the fluctuation around the critical point asymptotically converges to zero, as the number of atoms is increased. In contrast to the squeezed states of flying photons obtained using standard generation protocols with external driving, the squeezing obtained in the ground state of the ultrastrongly coupled photon–atom systems is resilient against unpredictable noise.
Exploring e- waste recycling behaviour intention among the households: Evidence from India
Authors: Vijayan Ravi Varma , Krishnan Malar Mathi , Parayitam Satyanarayana , Duraisami Shalini Prieya Anantharaman , Rathnaraj Narendra 
Published: October 2022

Abstract
The content of the study is to look into the origins and outcomes of recycling intentions. A conceptual model was built and evaluated in a productive result-oriented way following the principle of Theory of Planned Behaviour as a foundation (TPB). We investigated the effect of attitude, subjective norms, and hence perceived behavioural control on household inhabitants' recycling intentions empirically. We also studied the link between recycling intentions, habits, and convenience, as well as recycling behaviour. A structured investigation instrument was used to collect data from 228 respondents from households in a major metropolis in India's south region.. The hypotheses were tested using the hierarchical regression method. The results of hierarchical regression demonstrate that (i) recycling intention is strongly linked to attitude, subjective norms, and perceived behavior control. and (ii) recycling intention, habits, and convenience are positively associated with the recycling behavior of household residents. This research adds to our understanding of local residents' recycling habits. To the best of our knowledge, the conceptual framework designed and evaluated on the Indian subcontinent were limited and it contributes to the large number of recycling intention studies and behavior.
Vascular Parameters and Endothelin 1 Measurements in Glaucoma Patients With Low and High-tension Optic Disc Hemorrhages
Authors: Almeida Izabela N F , Taniguchi Elise , Tito Cecília Victoria Agapito , Dias Diego Torres , Ushida Michele , Dorairaj Syril , Ritch Robert , Teixeira Sérgio H , Paranhos Augusto , Gracitelli Carolina P B , Kayser Cristiane , Prata Tiago Santos 
Published: October 2022

Abstract
Purpose: To compare vascular parameters, assessed by endothelin-1 (ET-1) blood levels, Laser Doppler Imaging (LDI) of distal phalanx, and nailfold capillaroscopy (NC), between open-angle glaucoma (OAG) patients with low (LTDH) and high-tension optic disc hemorrhages (HTDH).
Methods: In this prospective study, patients were classified as LTDH if presenting an IOP<16 mmHg and HTDH if an IOP³16 mmHg at the time of DH detection. Demographic and ophthalmological data, ET-1 concentration, LDI (before and after 1, 10 and 20 minutes after cold stimulation) and NC findings were evaluated.
Results: Thirty-tree patients were included (mean age, 62.3±13 years). Regarding ET-1 blood level, it was 65% higher in the LTDH group (2.27±1.46 pg/ml) compared to the HTDH (1.37±0.57 pg/ml; p=0.03). In addition, there was a significant negative correlation between ET-1 blood concentration and IOP at the time of DH detection (r=-0.45; p=0.02). Blood flow measurement in LTDH patients were lower than those observed in patients with HTDH 10 and 20 minutes after cold stimulus (p<0.01).
Conclusion: Patients developing DH with lower IOPs have higher ET-1 blood levels and more peripheral vascular dysfunction (than those with higher IOPs), as estimated by LDI. These findings suggest that distinct underling mechanisms maybe involved in patients developing DH with different IOP ranges.