bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multielement Doping Engineered Iron Oxide Nanoparticles: Enabling the Shift from Negative to Positive MRI Contrast for Enhanced Diagnostic Precision
Authors: Lu Chichong , Bao Yingjie , Fei Zihan , Wang Zhijie , Ma Junjie , Ren Ruimin , Xu Xue , Zhang Yang 
Published: February 2025

AbstractContrast‐enhanced magnetic resonance imaging (CE‐MRI) is a crucial tool for the diagnosis and management of various diseases globally. Iron oxide nanoparticles with sizes less than 5 nm are expected to address the long‐term toxicity and brain accumulation issues associated with clinical gadolinium‐based T1 contrast agents (GBCAs) due to their non‐toxicity and biodegradability. However, synthesizing sub‐5‐nanometer particles presents significant challenges that complicate their clinical translation. Herein, traditional iron oxide‐based negative (T2) agents into positive (T1) agents are transformed and an all‐in‐one multielement doping strategy is developed. Multiple elements into iron oxide crystals are introduced to form multielement doping engineered iron oxide nanoparticles (MDE‐IONPs) and their surfaces with flexible hydrophilic ligands are subsequently modified. It is shown that Ni (II) and Gd (III) doping engineered nanoparticles can effectively enhance imaging efficacy, reducing clearance rates, and enabling controlled synthesis. Ultimately, the implementation of Ni (II) and Gd (III) co‐engineering yield longitudinal relaxivity of up to 14.7 mM−1s−1 even for particles as large as 9 nm, an improvement of approximately 300% over GBCAs. Combined with the stability, biosafety, both in vitro and in vivo results suggest that all‐in‐one multielement doping is a favorable strategy for advancing the development of next‐generation safe MRI contrast agents.
Ti3C2Tx‐Based Cross‐Scale Laminated Structural Structures: Enabling Sub‐Wavelength Impedance Modulation and Underwater Broadband Sound Absorption
Authors: Gan Ziwen , Qi Ranran , Chen Bowen , Tu Wei , Liao Mingyi 
Published: February 2025

AbstractDesigning underwater acoustic absorbing materials with sub‐wavelength thickness in the mid‐to‐low frequency range (400–4000 Hz) remains a challenge, especially for broad frequency applications. Most current designs focus on a single spatial scale, limiting their frequency range. To address this, a composite material (MPSFn‐SBR) made of Ti3C2Tx‐polyvinyl alcohol self‐assembled films(MPSFn) and styrene‐butadiene rubber (SBR) is designed, featuring a cross‐scale laminated structure. On a macroscopic scale, the MPSFn‐SBR has a sandwich structure, with the SBR layer serving as a protective layer and the MPSFn core modulating impedance. On a mesoscopic scale, the MPSFn layers transform longitudinal waves into shear waves, improving sound absorptionat mid‐to‐low frequency range. On a microscopic scale, the MPSFn's two‐phase coexistence system with a defect phase enriches vibration modes, broadening the absorption bandwidth. Results demonstrate that the cross‐scale laminated structure enables effective sound absorption at sub‐wavelength thickness (10 mm, ≈1/375 of the wavelength). A broad peak is observed from 1200 to 4000 Hz, with an average absorption coefficient of 0.91. The maximum absorption in the 400–1200 Hz range is 0.7. This study expands the design perspective of underwater sound‐absorbing materials, transitioning from a single spatial scale to a comprehensive strategy, fostering innovation and development in the field.
Advanced Poly (Ether Ether Ketone) Separator for Lithium Metal Battery
Authors: Zeng Xingyan , Chen Yi , Nie Hui , Yang Yufei , Chen Jie , Pei Huijie , Wang Xuyang , Yang Yanchao , Pang Jinhui , Zhou Xingping , Wang Guibin , Xie Xiaolin 
Published: February 2025

AbstractThe development of high‐performance separators is urgently needed to improve the safety and electrochemical performance of high‐energy‐density lithium metal batteries (LMB). Poly (ether ether ketone) (PEEK) is an ideal separator candidate due to its high chemical resistance and excellent thermal stability. However, the processing of PEEK for separators with proper porous structure is rather challenging. Beyond the conventional sulfonation process of PEEK, here, a reversible chemical modification strategy is exploited to fabricate heat‐resistant PEEK separators with sophisticated hierarchical pore architecture. The lyophilic PEEK separators including dense surface layers, middle layers with horizontally aligned pore arrays, and honeycomb‐structured bottom layers enable fast ion transport and uniform Li+ flux, realizing dendrite‐free characteristics during the lithium deposition process. Hence, the PEEK separator assembled LiFePO4||Li battery delivers a remarkable capacity of 103.6 mAh·g−1 after 1000 cycles at 3 C, and offers more than two times longer cycle life than that of other PEEK‐based separators. Even at 70 °C, a high capacity retention rate of 84.2% is achieved after 200 cycles, ensuring battery safety in high‐temperature environments. Different from the commonly used surface modification strategy for functional separators, the approach reported herein exhibits a fundamental advance in separator manufacturing for future high‐safety LMBs.
Bilateral Synergistic Effects of Phototherapy‐Based NIR‐II Absorption Photosensitizer for Allergic Rhinitis
Authors: Shao Tao , Han Lu , Xie Yang , Shi Zhenxiong , Yang Qilong , Liu Aojie , Liu Yi , Chen Langlang , Huang Jingman , Peng Bo , Bai Hua , Chen Hongli , Li Lin , Bian Ka 
Published: February 2025

AbstractAllergic rhinitis (AR) is the most prevalent global health issue, affecting approximately 3 billion people, with its incidence increasing annually. The current first‐line pharmacotherapy for symptom relief has limited efficacy and often results in notable side effects. Here, aza‐BODIPY‐based nanoparticles (RH@NPs) are developed that exhibit mild photothermal therapy (PTT) and type I photodynamic therapy (PDT) capabilities. Enhanced intramolecular charge transfer induces NIR‐II absorption of the photosensitizer (RH), facilitating deeper tissue penetration for augmented AR therapy. Additionally, the use of an asymmetric donor–acceptor–acceptor′ configuration promotes the self‐assembly of RH, enhancing its intersystem crossing ability and enabling efficient photophysical activity. The synergistic effects of PTT (enhancing HSF1 DNA‐binding activity to inhibit epithelial‐mesenchymal transition by epigenetically regulating the expression of epithelial‐mesenchymal transition‐associated genes) and PDT (activating NRF2 transcriptional activity to stimulate the antioxidant defense system) enable RH@NPs to provide a superior therapeutic effect in a mouse model of AR. This effect is achieved by mechanically reducing the allergic response rather than merely alleviating symptoms. Notably, the photosensitizer‐based physical therapy demonstrates enhanced safety. This study is the first to successfully investigate the application of phototherapy for AR and elucidate its mechanism of action, offering a novel, straightforward, and efficient treatment strategy for AR.
pH‐Responsive DNA‐Functionalized Liquid Metal–Organic Frameworks (L‐MOFs) as Molecular Sponges for Ultrasensitive and Label‐Free SERS Detection of Folic Acid
Authors: Liu Xu , Glazutdinova Liliia , Wu Guangrun , Yang Wenxu , Liu Hongbo , Shen Yifu , Zhang Siyao , Wu Jing , Ji Haoyu , Gao Lixin , Gao Xinlu , Zhao Jiayi , Li Yang , Liu Yu 
Published: February 2025

AbstractAlthough “hotspots” have been utilized to enhance Raman signals for detecting various biomolecules, precisely regulating “hotspot” dimensions within enhancement substrates remains a significant challenge. This study introduces a novel, easily fabricated surface‐enhanced Raman spectroscopy sensor, T6(OH⁻)/Ag@CC. This platform employs single‐stranded DNA of adjustable lengths to mediate the self‐assembly of silver nanoparticles (Ag NPs), resulting in a uniformly enhanced substrate with a spatially organized metal–organic frameworks architecture. The DNA‐mediated self‐assembly exhibits pH‐responsive characteristics, enabling precise control over “hotspot” distribution. Comprehensive characterization and Raman enhancement experiments demonstrate that optimal self‐assembly and signal amplification are achieved under alkaline conditions. The sensor demonstrates excellent reproducibility and sensitivity, enabling the label‐free detection of folic acid with a detection limit as low as 0.1 ng mL−1. Validation using real‐world food and biological samples highlights its ability to accurately detect and identify folic acid fingerprints in spinach, chicken liver, and various human biological fluids, including breast milk, serum, erythrocytes, and urine. The analysis of characteristic peak intensities underscores the potential of this method as a versatile and unified approach for folic acid detection across diverse sample matrices.
Impact of mixed boundary conditions on stochastic equations with noise at the boundary
Authors: Fkirine M. , Hadd S. , Rhandi A. 
Published: February 2025

Abstract
In this paper, we study evolution equations that are perturbed at the boundary by both noise and an unbounded perturbation. First, using the theory of regular linear systems, we prove the existence of solutions to this equation. Second, we investigate the long-time behavior of the solutions, such as the absolute continuity and the existence of an invariant measure.
Long-term outcomes of cemented compared to uncemented femoral stems in total hip arthroplasty for displaced femoral neck fractures in elderly patients
Authors: Axenhus Michael , Chammout Ghazi , Kelly-Pettersson Paula , Mukka Sebastian , Magnéli Martin , Sköldenberg Olof 
Published: February 2025

Abstract

Background
Total hip replacement (THR) is commonly used for active and lucid elderly patients with displaced femoral neck fractures (FNF). Historically, cemented stems have been favoured, demonstrating superior early outcomes. Controversy still exists regarding the use of cemented or uncemented stems in the most active group of patients with FNF and there is a need for extended follow-up studies to assess long-term outcome of cemented and uncemented stem results.

Methods
A 4 and 10-year follow-up was conducted on a single-centre, single-blinded, randomized controlled trial. Patients aged 65–79 years with an acute displaced FNF (Garden III–IV) were included, and surgeries were performed between 2009 and 2014. The study was terminated after an interim analysis indicated that the total number of early hip-related complications was substantially higher in the uncemented group. Baseline and follow-up assessments included hip-related complications, reoperations, health-related quality of life scores, Harris hip score and pain ratings.

Results
In total, 69 patients were randomized. At 4 years, there were 8 complications in the uncemented group and 2 complications in the cemented groups. The uncemented group had several periprosthetic fractures and dislocations necessitating revisions in several cases. From 4 to 10 years, the cemented group showed a single periprosthetic fracture, while none occurred in the uncemented group. The total number of complications during the study period were 8 in the uncemented group and 3 in the cemented group. The median Harris hip score for the uncemented group remained consistent at 81 for both the 4- and 10-year follow-ups. In contrast, the cemented group showed scores of 92 and 93 at the respective 4- and 10-year follow-ups, with no statistically significant difference between the two groups. Health-related quality of life and pain ratings were similar between groups throughout the study.

Conclusion
Our study presents a 10-year follow-up of uncemented femoral stems in THR for elderly FNF patients. Our findings not only underscore the importance of cautious decision-making in selecting patients for uncemented implants, but also highlight that most patients suitable for THR would benefit from a cemented arthroplasty to avoid an increased risk of short-term complications.
Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society
Authors: Devigili G. , Di Stefano G. , Donadio V. , Frattale I. , Grazzi L. , Mantovani E. , Nolano M. , Provitera V. , Quitadamo S. G. , Tamburin S. , Truini A. , Valeriani M. , Furia A. , Vecchio E. , Fischetti F. , Greco G. , Telesca A. , de Tommaso M. ,   On behhalf of neuropathic pain special interest group of the Italian neurological society (sin)
Published: February 2025

Abstract

Background
Although fibromyalgia is a disabling disease, there is no targeted therapy for specific neurotransmitters or inflammatory mediators. Our aim was to provide neurologists with practical guidance for the management of these difficult patients based on a critical, narrative and non-systematic review of randomized controlled trials (RCTs) from the last 10 years.

Methods
The members of the Special Interest Group Neuropathic Pain of the Italian Neurological Society evaluated the randomized controlled trials (RCTs) of the last 10 years and answered questions that allow a consensus on the main pharmacological and non-pharmacological approaches.

Results
The neuropathic pain working group agreed on prescribing antiepileptic drugs or antidepressants in the case of comorbidities with anxiety and depression. As a second choice, experts have agreed on the association of antiepileptics and antidepressants, while they disagree with the use of opioids. Medical cannabis and nutraceuticals are promising new treatment options, although more data is needed to prove their efficacy. The neurologists agreed in suggesting physical activity at the first visit, particularly aerobic and strength training. As a second choice, they considered a cognitive behavioral therapy approach to be useful.

Conclusions
Pharmacologic treatment with antiepileptic drugs and antidepressants in patients with co-occurring anxiety and depression, as well as an early nonpharmacologic approach based primarily on physical activity, may be a useful indication in contemporary neurology clinical practice. Non-pharmacological options, such as cognitive behavioral therapy and non-invasive brain stimulation NIBS, could improve evidence of efficacy and lead to relevant improvement in FM-related disability.
Efficacy of urinary [TIMP-2]⋅[IGFBP7], L-FABP, and NGAL levels for predicting community-acquired acute kidney injury in Japanese patients: a single-center, prospective cohort study
Authors: Inotani Satoshi , Kashio Takeshi , Osakabe Yuki , Matsumoto Tatsuki , Nagao Yoshiki , Ishihara Masayuki , Iwata Hideki , Mitani Keita , Hatakeyama Yutaka , Horino Taro 
Published: February 2025

Abstract

Background
The combination of urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) ([TIMP-2]⋅[IGFBP7]) has emerged as a strong predictor of acute kidney injury (AKI), which is associated with poor outcomes. However, most studies have focused on non-Asian populations, and comparisons of [TIMP-2]⋅[IGFBP7] with other AKI biomarkers in Asian populations have not been performed. Furthermore, no study has examined the efficacy of [TIMP-2]⋅[IGFBP7] for predicting community-acquired AKI.

Methods
We prospectively enrolled adult patients at Kochi Medical School Hospital in Kochi, Japan, and performed a receiver-operating characteristic (ROC) curve analysis to assess the ability of [TIMP-2]⋅[IGFBP7], neutrophil gelatinase-associated lipocalin (NGAL), and liver fatty acid-binding protein (L-FABP) measured at the time of admission to predict AKI.

Results
Of the 170 enrolled patients, 40 (23.5%) developed AKI. Risk factors for AKI development were male sex, history of hypertension, low albumin levels, and high [TIMP-2]⋅[IGFBP7] and NGAL levels. The ROC curve analysis showed that the area under the ROC curve (AUC) of [TIMP-2]•[IGFBP7] for predicting AKI was 0.804 (95% confidence interval [CI], 0.728–0.880); however, the AUCs of L-FABP and NGAL were 0.688 (95% CI, 0.594–0.782) and 0.726 (95% CI, 0.639–0.813), respectively.

Conclusion
Urinary [TIMP-2]⋅[IGFBP7] is a good predictor of community-acquired AKI.
Blending Teacher Autonomy Support and Provision of Structure in the Classroom for Optimal Motivation: A Systematic Review and Meta-Analysis
Authors: Patzak Alexandra , Zhang Xiaorong 
Published: February 2025

Abstract
Teacher autonomy support and provision of structure are crucial for students’ learning and motivation, yet it is unclear how to best blend them. Research describes autonomy support and structure as independent but mutually supportive, equivalent, and even opposite. These contradictions jeopardize the generalizability of findings across studies and hamper classroom implementation. Our meta-analysis aims to disentangle the dynamics between autonomy support and structure by synthesizing their definitions, relationships, and effects on students. Following PRISMA guidelines, 94 studies and 110 effect sizes were identified through databases (PsycINFO, ERIC, Education Research Complete, Psychology and Behavioral Sciences Collection, Teacher Reference Center, ProQuest Education Database, and ProQuest Theses & Dissertations) and forward reference searches. Dissertations and peer-reviewed articles examining teacher autonomy support and structure were included. Our synthesis revealed intertwined conceptualizations and plentiful operationalizations of autonomy support and structure. Autonomy support and structure reinforced each other, with a large effect size. This relationship was moderated by the data collection method and school level and appears to be universal. Autonomy support and structure both elevated students’ motivation, engagement, and need satisfaction with moderate to large effect sizes. Teachers who facilitate autonomy and structure were motivated to teach and felt effective as teachers. Our findings suggest blending autonomy support and structure for optimal growth of students and teachers.
Chronic Parenting Stress in Parents of Children with Autism: Associations with Chronic Stress in Their Child and Parental Mental and Physical Health
Authors: van der Lubbe Anna , Swaab Hanna , Vermeiren Robert , van Rossum Elisabeth F. C. , van Balkom I. D. C. , Ester Wietske A. 
Published: February 2025

Abstract
Parents of children with ASD often demonstrate high levels of stress and associated health problems. A gap in knowledge exists regarding the associations between chronic stress and mental and physical health of parents of young children with ASD, in which fathers have been understudied. In 181 parents (98 mothers, 83 fathers) of 99 young children with ASD chronic stress was measured using parental self-report and hair cortisol concentration (HCC) analysis. Parental mental health and eating behavior was measured using questionnaires. Physical health was evaluated by Body Mass Index, waist circumference, blood pressure, cholesterol, triglycerides, and glucose.. Parental HCC was related with child HCC (r

mothers
= 0.51, p <.01; r

fathers
= 0.40, p <.01). Maternal HCC was associated with lower reported parenting stress (r = −.33, p <.01). Parental mental health problems and reported parenting stress were strongly related (r =.55-0.61, p <.01). Mental health problems were twice as frequent as in the norm-population (41.1–45.8% versus 20%). In both parents, reported parenting stress was associated with emotional eating behavior. HCC was associated with higher glucose levels in mothers. There were no associations between chronic stress and the other physical health measures in mothers and fathers. Parents of young children with ASD are at high risk for chronic stress, with impact for their mental and physical health. Additionally, chronic stress of parents, cannot be perceived isolated from the stress in their children with ASD. We encourage future research to investigate whether these correlations are generalizable to the whole ASD population.
Examen Tu Salud: A Digital Spiritual Health Intervention for Young Adult US Latinas
Authors: L’Engle Kelly , Landeros Adam , Trejo Evelin 
Published: February 2025

Abstract
Although spiritual health is a core dimension of health and wellness, particularly for Latinos, it receives limited attention in health promotion interventions. Examen Tu Salud is a brief intervention for young Latinas in the USA and is designed using culturally tailored spiritual messaging and education provided through daily multimedia messages and weekly remote peer coaching rooted in Ignatian values and pedagogy. Results from this single group intervention study showed that after four weeks, participants reported large increases in spiritual health (Cohen d = 0.82), well-being (Cohen d = 0.91), and happiness (Cohen d = 0.84), and moderate reductions in stress (Cohen d = 0.41) and anxiety (Cohen d = 0.49). These findings further develop the spiritual health intervention literature and establish a baseline for future brief digital health interventions to support Latinas and other groups using culturally tailored spiritual health messaging.
Copper-based fungicide application shifts the soil bacterial community structure and the soil nitrogen cycle
Authors: Schneider Martin , Deltedesco Evi , Gorfer Markus , Berger Harald , Breiner Lisa , Paumann Melanie , Soja Gerhard , Mentler Axel , Zechmeister-Boltenstern Sophie , Wenzel Walter W. , Zehetner Franz , Keiblinger Katharina M. 
Published: February 2025

Abstract

Purpose
Through high sorption affinities of Copper (Cu) to soil organic matter, excessively applied Cu generates complex responses by numerous soil functions, e.g. microbial nutrient cycling, that are relying on organic matter decomposition.

Methods
Effects of Cu on soil nitrogen (N) transformation were investigated on a bacterial community level with complying N-functional genes, enzymatic activities and N-pools. Up to 5000 mg Cu kg−1 were applied to an acidic sandy loam (AS) and a calcareous silt loam (CL). An eco-toxicological greenhouse pot experiment was carried out and sampled after 28 and 106 days during the growth of Medicago sativa.

Results
In both soils, the urease activity and ammonium increased with Cu, whereas nitrate decreased. This reduced the mineral N, much stronger in the AS than in the CL. The microbial N rather declined, but the ammonia oxidation via amoA increased, especially in the AS. The NO2
−-reductase via nirS declined continuously, while nirK increased up to 200 mg Cu kg−1. The dominating denitrifying Pseudomonas decreased, the community shifted towards saprotrophs at 500 and 1500 mg Cu kg−1 in the AS and CL, respectively.

Conclusions
Shifts in the N-cycle and pool sizes resulting from excessive Cu became apparent in this study. The soil texture- and pH-governed bioavailability affected the Cu-derived responses and indicated a higher sensitivity of the AS. The increasing abundance of Pseudoxanthomonas, i.e. solely capable of dissimilatory nitrite reduction to ammonium suggested Cu-related shifts to this N-pathway. This explains the elevated ammonium concentrations, but not the reduced mineral N-pool.

Graphical Abstract