bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Psoriasis-Genes to readout Overlap Pathways from TCGA
Authors: Zhu Kunju , Liang Lifan , Fan Xiaonan , Lu Songjian 
Published: September 2022

Abstract
One major challenge in studying the psoriasis is the lack of multi-omics and sufficient measurement datasets for psoriasis, which only provides limited insights into the pathogenesis of psoriasis. As the psoriasis is associated with the dysfunction of pathways, the pathogenesis of psoriasis can be investigated with the aids of big omics data from tumors in The Cancer Genome Atlas (TCGA), a data set that is in fact the records of random pathway perturbation experiments performed by nature. We first collect psoriasis related genes found by previous researches of psoriasis. We then utilize the gene expression and genomic alteration data from thousands of tumors in TCGA cohort to identify genomic alterations that potentially perturb pathways regulating expressions of these psoriasis related genes. We have found that genomic alterations of some genes are associated with the expression changes of psoriasis related genes in tumors, which implies that the genomic alteration of these genes may perturb pathways involved in the development of the psoriasis. For example, we found that SGAs of certain genes (E.g., TNFAIP8L3, IL-23, ANGPT2, IFIH1) are highly likely to be involved in the pathogenesis of psoriasis. Enrichment analysis showed that SGAs of these genes perturb signaling pathways regulating cell proliferation and/or angiogenesis-relevant activities of cells, which are well-known to be biologically related to the development of both psoriasis and cancers. The approach of using big genomic data of tumors to search for pathways involved in the psoriasis development gains insights into the mechanism of psoriasis.
Constructing and optimizing ecological network at county and town scale: The case of Shilin County, China
Authors: Miao Xue , Jin Jing , Peng Jiansong 
Published: September 2022

Abstract
High-intensive land development had led to increasingly fragmented urban habitat patches, and the contradiction between regional development and ecological protection is gradually intensified. This ecological problem is spreading from cities to counties and towns, which are mainly villages and towns. Constructing a reasonable ecological network is an effective way to connect fragmented habitats and balance regional morphological and spatial patterns. Taking the Shilin County of the Yunnan province, China as the study area, morphological spatial pattern analysis and connectivity analysis were used together to identify the key ecological source areas and their importance levels. The comprehensive resistance surface based on the migration characteristics of terrestrial animals was assembled based on five variables (altitude; slope; distance to road; distance to population centers; land use map). The gravity model was used to identify the priority of the ecological corridors, and the ecological networks was derived. The results show that the initially constructed ecological network includes 11 ecological sources and 26 ecological corridors, of which seven are important ecological corridors that need priority construction. However, the ecological networks were less distributed in the northern regions, so three supplementary ecological sources and ten supplementary ecological corridors were added to optimize the ecological network. In addition, there are significant differences in the size and number of ecological source sites and corridors between townships, and targeted construction strategies are necessary. The in-depth analysis from county to township makes the construction and management of ecological networks more maneuverable in national administration. This study provides guidance for constructing ecological network structures in townships with complex landscape types, and may also provide lessons for other regions. Through an in-depth analysis from county to town, this study can provide guidance to construct the township ecological network structure with complex landscape types and provide reference for other regions as well.
Isolation and screening of lactic acid bacteria producing anti-edwardsiella from the gastrointestinal tract of wild-caught catfish (Clarias gariepinus) for probiotic candidates
Authors: Nurhayati Awik P.D , Zulaika Enny , Amin Muhamad , Setiawan Edwin , Wijaya Zaki Muhammad 
Published: September 2022

Abstract
Members of lactic acid bacteria (LAB) have been well-known for their antagonistic activities against various bacterial pathogens infecting aquaculture species. Thus, isolation of LAB members from wild aquatic species and screening them for antimicrobial production have been intensively done in the last few decades to replace the indiscriminative use of antibiotics. The present study aimed at isolating LAB members from the intestinal tract of wild-caught catfish, Clarias gariepinus, and screening them for antimicrobial production against one of the most common bacterial pathogens, Edwardsiella ichtaluri. The result showed that a total of 29 LAB were successfully isolated and further screened for anti-edwarsiella activities. Of the 29, 6 isolates had strong anti-Edwardsiella activity (diameter of inhibition zone > 10mm). Based on their 16s rRNA gene sequences, these LABs were identified as Lactococcus lactis, Enterococcus hirae, Weissella confusa, Weissella cibaria, and Enterococcus faecalis (2 isolates). Further in vitro studies indicated that E. faecalis, L. lactis, E. confusa and E. cibaria showed the same viability except for E. hirae in the intestinal fluid simulation. All LAB had a good adhesion capacity to intestinal mucus between 3,42 − 16,72%. Four LABs were sensitive to erythromycin, oxytetracycline, and novobiocin, while E. faecalis and W. cibaria were resistant to novobiocin and enrofloxacin, respectively. In vivo assay also indicated that all six LABs were non-pathogenic to catfish. These results suggested that E. faecalis, L. lactis, and W. confusa are potential probiotic candidates in aquaculture to prevent enteric septicemia of catfish (ESC) disease. However, further studies are needed to evaluate the use of probiotics in vivo.
Thermodynamic factor and vacuum crystallization
Authors: Semenov Evgeniy , Slavyanskiy Anatoliy , Mitroshina Daria , Lebedeva Natalya 
Published: September 2022

Sucrose crystallization depends on various thermal phenomena, which makes them an important scientific issue for the sugar industry. However, the rationale and theory of sucrose crystallization still remain understudied. Among the least described problems is the effect of time and temperature on the condensation rate of sucrose molecules on crystallization nuclei in a supersaturated sugar solution. This article introduces a physical and mathematical heat transfer model for this process, as well as its numerical analysis.
The research featured a supersaturated sugar solution during sucrose crystallization and focused on the condensation of sucrose molecules on crystallization nuclei. The study involved the method of physical and mathematical modeling of molecular mass transfer, which was subjected to a numerical analysis.
While crystallizing in a vacuum boiling pan, a metastable solution went through an exothermal reaction. In a supersaturated solution, this reaction triggered a transient crystallization of solid phase molecules and a thermal release from the crystallization nuclei into the liquid phase. This exogenous heat reached 39.24 kJ/kg and affected the mass transfer kinetics. As a result, the temperature rose sharply from 80 to 86 °C.
The research revealed the effect of temperature and time on the condensation of solids dissolved during crystalline sugar production. The model involved the endogenous heat factor. The numerical experiment proved that the model reflected the actual process of sucrose crystallization. The obtained correlations can solve a number of problems that the modern sugar industry faces.
Disseminated Tuberculosis in an Immunocompetent State: A Case Report
Authors: Dinkar Anju , Singh Jitendra , Patel Nitish Kumar , Bhavya J  , Dewangan Ankita , Kumar Nilesh , Kumar Kalish 
Published: September 2022

Background:
Tuberculosis is one of the major infectious diseases of mankind and remains a
significant health concern, especially in developing countries. Clinical manifestations of TB are broad
and sometimes very challenging for clinicians to diagnose early. Tuberculous psoas abscess was generally
secondary to spinal tuberculosis or direct extension from adjacent structures in immunocompromised
individuals, but tuberculous psoas abscess in the immunocompetent state is very infrequent. In
addition, pancytopenia and new onset neck swelling simultaneously make this presentation a very unusual
clinical entity in tuberculosis.

Case Presentation:
We now present a case of a 21-years-old, unmarried, otherwise healthy girl presented
with fever, lower abdominal pain and weight loss for two months. She also noticed painless
neck swelling for 15 days. She later had a tuberculous left sided psoas abscess with pancytopenia and a
cold abscess on the left side of the neck with no sign of any other apparent focus, according to the evidence.
Diagnosis of disseminated TB without lung involvement was established and ATT was started.
The outcome was successful on follow up.

Conclusion:
Among the broad spectrum of atypical manifestations of TB, this case report draws attention
to its rarity, diagnostic challenge and awareness of the clinical spectrum, especially in developing
countries.
Evaluation of Remineralizing Effects of CPP-ACP and Nanohydroxyapatite on Erosive Lesions of Enamel in Deciduous Teeth After Exposure to Acetaminophen Syrup: An in vitro Study
Authors: Hadidi Fateme , Haghgoo Roza , Kameli Somaye , Ahmadvand Motahare 
Published: September 2022

Background:Oral pediatric liquid medications are commonly used in children who suffer from chronic diseases. Due to acid components in their formulations, these medications may possess a high erosive potential to dental tissues. Erosion is one of the major causes of degradation and demineralization of the enamel. If demineralization causes are not inhibited, it progresses and completely degrades the enamel. So, the dentin is exposed, and, finally, the pulp will be engaged in the process.Aim:This study aimed to evaluate the remineralizing properties of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and nanohydroxyapatite on erosive lesions caused by acetaminophen syrup intake in vitro.Methods:The microhardness of 34 healthy human primary molars was determined prior to and following a seven-day, three-times-a-day, one-minute exposure to acetaminophen syrup. The teeth were then randomly divided into four groups and were immersed in artificial saliva, fluoride gel, nano-hydroxyapatite, and CPP-ACP for 10 minutes. Then, their final microhardness was measured, and repeated-measures ANOVA analyzed the data.Results:Enamel microhardness in two groups decreased after exposure to acetaminophen syrup and increased after applying remineralization agents, CPP-ACP, and nano-hydroxyapatite. The two groups did not show significant differences in terms of microhardness increase (p-value=0.141).Conclusions:According to the findings of this study, CPP-ACP and nano-hydroxyapatite can improve the microhardness of enamel, which has been reduced as a result of exposure to medicinal syrups.
A Narrative Review of the Disenfranchisement of Single Mothers in Highland Ecuador
Authors: Pino Gavidia Lisbeth A. , MacDermid Joy C. , Brunton Laura , Doralp Samantha 
Published: September 2022

Background:
The Andean South American country of Ecuador presents social challenges that contribute to inequities. The social determinants of health have impacts on the physical, psychological and social health of individuals across all societies. Ecuador is an example of how the interactions of gender roles and social determinants of health impact the health of single mothers and their children.

Methods:
A retrospective historical literature review was conducted on gender role expectations within the rural context Ecuador to inform future public health strategies and health interventions.

Results:
Gender inequality contributes to higher rates of single parenting, child labour, and migration. Food insecurity and poverty are affected through the interface of economic hardships and rural agricultural livelihoods.

Conclusion:
The disenfranchisement of poor rural women in Ecuador is deeply rooted in historical gender discrimination, societal attitudes, and institutionalized gender bias that incur onto the society as a whole in terms of becoming less protectors and producers of human resources. The health of single mothers and children living in poverty and their ability to create a healthy family environment will not improve until women explore their productivity and creativity amid social tensions and livelihood struggles.
Impact of an eHealth Smartphone App on Quality of Life and Clinical Outcome of Patients With Hand and Foot Eczema: Prospective Randomized Controlled Intervention Study
Authors: Weigandt Wanja Alexander , Schardt Yannic , Bruch Aimee , Herr Raphael , Goebeler Matthias , Benecke Johannes , Schmieder Astrid 
Published: September 2022

Background
Chronic hand and foot eczema is a polyetiological dermatological condition. Patients experience pain, itching, and sleep disturbances and have a reduced quality of life. Skin care programs and patient education can improve the clinical outcome. eHealth devices offer a new opportunity to better inform and monitor patients.

Objective
This study aimed to systematically analyze the effect of a monitoring smartphone app combined with patient education on the quality of life and clinical outcome of patients with hand and foot eczema.

Methods
Patients in the intervention group received an educational program; attended study visits on weeks 0, 12, and 24; and had access to the study app. Patients in the control group attended the study visits only. The primary end point was a statistically significant reduction in Dermatology Life Quality Index, pruritus, and pain at weeks 12 and 24. The secondary end point was a statistically significant reduction in the modified Hand Eczema Severity Index (HECSI) score at weeks 12 and 24. This is an interim analysis at week 24 of the 60-week randomized controlled study.

Results
In total, 87 patients were included in the study and randomized to the intervention group (n=43, 49%) or control group (n=44, 51%). Of the 87 patients, 59 (68%) completed the study visit at week 24. There were no significant differences between the intervention and control groups regarding quality of life, pain, itch, activity, and clinical outcome at weeks 12 and 24. Subgroup analysis revealed that, compared with the control group, the intervention group with an app use frequency of fewer than once every 5 weeks had a significant improvement in the Dermatology Life Quality Index at weeks 12 (P=.001) and 24 (P=.05), in pain measured on a numeric rating scale at weeks 12 (P=.02) and 24 (P=.02), and in the HECSI score at week 12 (P=.02). In addition, the HECSI scores assessed on the basis of pictures taken by the patients of their hands and feet correlated strongly with the HECSI scores recorded by physicians during regular personal visits (r=0.898; P=.002) even when the quality of the images was not that good.

Conclusions
An educational program combined with a monitoring app that connects patients with their treating dermatologists can improve quality of life if the app is not used too frequently. In addition, telemedical care can at least partially replace personal care in patients with hand and foot eczema because the analysis of the pictures taken by the patients correlates strongly with that of the in vivo images. A monitoring app such as the one presented in this study has the potential to improve patient care and should be implemented in daily practice.

Trial Registration
Deutsches Register Klinischer Studien DRKS00020963; https://drks.de/search/de/trial/DRKS00020963
Interactive Conversational Agents for Health Promotion, Prevention, and Care: Protocol for a Mixed Methods Systematic Scoping Review
Authors: Sasseville Maxime , Barony Sanchez Romina H , Yameogo Achille R , Bergeron-Drolet Laurie-Ann , Bergeron Frédéric , Gagnon Marie-Pierre 
Published: September 2022

Background
Interactive conversational agents, also known as “chatbots,” are computer programs that use natural language processing to engage in conversations with humans to provide or collect information. Although the literature on the development and use of chatbots for health interventions is growing, important knowledge gaps remain, such as identifying design aspects relevant to health care and functions to offer transparency in decision-making automation.

Objective
This paper presents the protocol for a scoping review that aims to identify and categorize the interactive conversational agents currently used in health care.

Methods
A mixed methods systematic scoping review will be conducted according to the Arksey and O’Malley framework and the guidance of Peters et al for systematic scoping reviews. A specific search strategy will be formulated for 5 of the most relevant databases to identify studies published in the last 20 years. Two reviewers will independently apply the inclusion criteria using the full texts and extract data. We will use structured narrative summaries of main themes to present a portrait of the current scope of available interactive conversational agents targeting health promotion, prevention, and care. We will also summarize the differences and similarities between these conversational agents.

Results
The search strategy and screening steps were completed in March 2022. Data extraction and analysis started in May 2022, and the results are expected to be published in October 2022.

Conclusions
This fundamental knowledge will be useful for the development of interactive conversational agents adapted to specific groups in vulnerable situations in health care and community settings.

International Registered Report Identifier (IRRID)
DERR1-10.2196/40265
Infection Control Risk Assessment Pelayanan Kebidanan di Klinik Pratama Kota dan Kabupaten Cirebon
Authors: Nurfikri Ari , Nurhasanah Nurhasanah 
Published: September 2022

Latar Belakang: USAID mengeluarkan Infection Control Assessment Tool for Primary Health Care Facilities (ICAT) modul 7 yang menilai pengendalian infeksi terkait penanganan persalinan dan nifas, tetapi belum banyak dilakukan pada layanan primer yang melayani pertolongan persalinan di Indonesia. Tujuan : Membandingkan capaian penilaian risiko infeksi pelayanan kebidanan di Klinik Pratama kota dan kabupaten di Cirebon menggunakan instrument Infection Control Assessment Tool for Primary Health Care Facilities (ICAT) modul 7.Metode: Penelitian observasional dengan pendekatan deksriptif. Perbandingan capaian penilaian risiko infeksi pelayanan kebidanan dilakukan di dua klinik pratama kota dan kabupaten Cirebon yaitu Klinik Akbid Muhammadiyah dan Klinik Dunia Medika menggunakan instrument ICAT modul 7 yang terdiri dari 8 indikator penilaian.Hasil: Capaian dari bagian satu sampai delapan dari Klinik Akbid Muhammadiyah memiliki rerata 66, 33%, dan capaian Klinik Dunia Medika 67,70%, masuk dalam ketegori baik.Kesimpulan: Angka kematian ibu dapat ditekan apabila layanan primer dalam hal ini klinik yang melayani pertolongan persalinan memiliki capai 100% pada setiap bagian di modul tujuh ICAT.
Rivaroxaban for the prevention of outcomes in patients with atrial fibrillation in clinical practice: an indirect comparison of national and international registries
Authors: Marin Francisco , Fernández Marcelo Sanmartín , Lekuona Iñaki , Arribas Fernando , Barón-Esquivias Gonzalo , Barrios Vivencio , Cosin-Sales Juan , Freixa-Pamias Román , Masjuan Jaime , Pérez-Cabeza Alejandro I , Schilling Vanessa Roldán , Vázquez Rodríguez José Manuel , Priu Carles Rafols , Sánchez Manuel Anguita 
Published: September 2022

Objective:
To analyze the effectiveness and safety of rivaroxaban in patients with atrial fibrillation (AF).
Methods:
The clinical profile and outcomes of the EMIR study were indirectly compared with those of ROCKET-AF, eight other Spanish observational studies and XANTUS.
Results:
In EMIR, mean age was 74.2 years and CHA
2
DS
2
-VASc was 3.5. In the rivaroxaban arm of the ROCKET-AF trial, mean age was 73 years and CHADS
2
was 3.5, whereas in the Spanish studies mean age ranged from 74.9 years to 78.4 years and CHA
2
DS
2
-VASc from 3.5 to 4.3. In EMIR, rates of stroke/systemic embolism, major adverse cardiovascular events, cardiovascular death and major bleeding were 0.57, 1.07, 0.63 and 1.04 events/100 patient-years, respectively. In ROCKET-AF, these numbers were 1.7, 3.91, 1.53 and 3.6 events/100 patient-years, respectively. In the Spanish studies, rates of stroke and major bleeding were 0–1.8 and 0.22–4.2 events/100 patient-years, respectively. In XANTUS, rates of stroke, major adverse cardiovascular events and major bleeding were 0.7, 1.8 and 2.1 events/100 patient-years, respectively.
Conclusion:
Despite the fact that rivaroxaban is prescribed for elderly patients with a high thromboembolic risk, rates of outcomes remain low.
Antibiotic Resistance of Bacteria Isolated from Urinary Tract Infections
Authors: Sergiu Chirila , Tony Hangan , Mihaela Botnarciuc 
Published: September 2022

Abstract
The aim of this study was to evaluate the antimicrobial resistance following in vitro testing for sensitivity of isolated bacteria from uncomplicated urinary tract infections.
We analysed all results for all urine culture tests performed in a two months period, retrospectively analyzing medical record from one laboratory.
We identified E. coli in 71.4% of the positive cultures, followed by Klebsiella pneumoniae, Staphylococcus aureus and Staphylococcus epidermitis. We identified 100% resistance of Gram negative bacteria in antimicrobials such as Cefuroxime and Ticarcillin. Fosfomycin and Amikacin provided good results, with high percentage of susceptible results.
Can the Use of Impepho Leaves Extend beyond Traditional to Modern Medicine? An Opinion
Authors: Belani Aviwe , Oladimeji Kelechi Elizabeth , Hyera Francis Leonard , Matubatuba Chrys , Juzang Ivan J 
Published: September 2022

Impepho is an indigenous African herb well known to most people in South Africa, particularly Eastern Cape and KwaZulu-Natal Provinces. The term “Impepho” is how the IsiXhosa speaking tribe from Eastern Cape called this herb while the IsiZulu’s from KwaZulu-Natal called it “Imphepho”. Despite documented uses for healing by traditional healers, especially in Africa, the healing abilities and mechanism of Impepho remain under-studied by science and medicine for modern drug development. There is a disconnection between medical scholars and traditional healers on how adequately and jointly to use this herb. We therefore urge researchers to work with traditional healers and medical professionals in South Africa and other African countries to carry out additional scientific studies on the Impepho herb.