bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Cytokine Profile between Postmenopausal Women with and
Without Osteoporosis – A Case-Control Study
Authors: Soh Geok Ting , Mohammad Affaf Hulma , Syed Isa Sharifah Nur Liyana , Chin Kok-Yong , Mohamed Norazlina 
Published: November 2022

Background:
Chronic low-grade inflammation is involved in the pathogenesis of postmenopausal osteoporosis, but the cytokines implicated remain elusive.

Objective:
This study aimed to compare the difference in cytokine profile between postmenopausal women with and without osteoporosis in Klang Valley, Malaysia.

Methods:
Postmenopausal women with (n = 20) and without osteoporosis (n = 20) were recruited
for this study. Their bone health status was determined using dual-energy X-ray absorptiometry.
Their fasting blood was collected for proteomic analysis. A protein array was performed for four
subjects randomly selected from each group to screen the potential cytokines. Three cytokines at
least 20% different between groups and consistently expressed by each subject were selected for
validation using enzyme-linked immunosorbent assays (ELISA).

Results:
The protein array screening demonstrated that platelet-derived growth factor-BB, interleukin-
6 receptor (IL-6R), and tissue inhibitor of metallopeptidase-2 were higher in women with
osteoporosis than women without osteoporosis (n = 4 per group), and consistently expressed by
all women. Only body mass index (BMI)-adjusted logarithmically transformed IL-6R levels were
lower among postmenopausal women with osteoporosis compared to women with normal bone
health (p = 0.026) (n = 16 per group) in the ELISA test.

Conclusion:
IL-6R was lower among postmenopausal women with osteoporosis compared to women with normal bone health after adjusting for BMI. However, a large-scale epidemiological study with proteomic analysis needs to confirm the findings.
Vaccines: An Important Tool for Infectious Disease
Authors: Saman Saika , Chauhan Iti , Srivastava Nimisha 
Published: November 2022

Abstract:
Vaccines are usually regarded as one of the most important tools in the battle
against infectious diseases. Even though currently accessible vaccinations are an incredible
success story in contemporary medicine and have had a significant impact on global
morbidity and death rates, it is evident that current vaccine delivery approaches need to
be improved. To allow the successful creation of vaccinations against contagious diseases
that have proven challenging to manage with conventional procedures, improvements
are necessary. Improvements could include the introduction of innovative injectable adjuvants
or novel delivery methods, such as mucosal immunization. Protection against infections
that infect mucosal areas may necessitate mucosal delivery.
Alternatively, innovative techniques for delivery, such as intradermal administration using
self-administrable devices or the use of microneedle technology to bypass the stratum
corneum's skin penetration barrier and aid in the transport of antigens, could be utilized
to increase vaccine compliance. Needle-free delivery systems are of particular relevance
for safer mass immunization programs, as they would prevent problems caused by needles
reuse in several regions of the world, as well as needle-stick accidents.
Based on this information, future vaccine development will mainly concentrate on rational
antigen, adjuvant, and, most importantly, delivery mechanism design, resulting in
new and improved vaccinations.
In addition, this study discusses the current state and prospects of vaccine delivery via a
variety of channels, including non- or minimally invasive approaches.
PENGEMBANGAN LATIHAN KETEPATAN TENDANGAN DALAM SEPAKBOLA UNTUK ANAK KELOMPOK UMUR 13-14 TAHUN
Authors: Anam Khoiril , Suharjana Suharjana 
Published: November 2022

Penelitian ini bertujuan untuk menghasilkan model latihan ketepatan tendangan dalam sepakbola untuk anak kelompok umur 13-14 tahun yang layak digunakan. Penelitian ini menggunakan desain penelitian pengembangan, dengan langkah-langkah terdiri dari: (1) mengenali potensi dan masalah, (2) pengumpulan data, (3) mengembangkan produk awal, (4) validasi desain, (5) revisi desain, (6) uji coba produk skala kecil, (7) revisi produk, (8) uji coba skala besar, (9) dan revisi produk, dan (10) hasil akhir. Penilaian kualitas produk melibatkan 3 orang ahli. Instrumen pengumpulan data yang digunakan yaitu pedoman umum wawancara, catatan lapangan, angket skala nilai validasi, pedoman observasi model, pedoman observasi keefektifan model, dan kuesioner untuk siswa. Teknik analisis data yang dilakukan yaitu analisis deskriptif kuantitatif dan analisis deskriptif kualitatif. Hasil penelitian ini berupa model latihan ketepatan tendangan yang terdiri dari (1) permainan passing segitiga; (2) permainan passing berpindah; (3) permainan pindah bola; (4) permainan melewati bola; (5) permainan passing dan koordinasi; (6) permainan cetak gol; (7) permainan 4 vs 2 target bola; (8) permainan 2 vs 1 target gawang; dan (9) permainan 2 vs 2 target gawang, yang disusun dalam bentuk DVD latihan dan buku panduan latihan.Kata Kunci: model latihan, ketepatan tendangan, sepakbola THE DEVELOPMENT OF PRACTICE KICK ACCURACY IN FOOTBALL FOR THE AGE GROUP OF 13 TO 14 YEARS OLD CHILDRENAbstractThis study aims to produce a model of practice kick accuracy in football for the age group of 13 to 14 years old children feasible to use. The study used research and development design, consisting the steps of (1) identified the potential and problems, (2) collect data, (3) develop initial products, (4) design a validation, (5) design revision, (6) small-scale product test, (7) product revision, (8) large-scale test, (9) product revision, and (10) the final result. Product quality assessment involving 3 experts. Instruments used for data collection are general guideline interviews, field notes, questionnaire validation value scale, the observation model, the effectiveness of observation model, and a questionnaire for students. The quantitative descriptive analysis and the qualitative descriptive analysis techniques are used to collect the data. The result of this research is a model of practice kick accuracy consisting of (1) triangular passing game; (2) passing and moving game; (3) moving the ball game; (4) passing the ball game; (5) passing and coordination game ; (6) scoring goal game; (7) target ball game of 4 vs 2; (8) target goal game of 2 vs 1; and (9) target goal game of 2 vs 2, arranged in a training DVD shape and training handbook.Keywords: models of practice, kicks accuracy, football
PENINGKATAN HASIL BELAJAR LOMPAT JANGKIT PESERTA DIDIK SMKN 2 PURWOREJO MELALUI LOMPAT RITMIK
Authors: Sugiyanto Sugiyanto , Lumintuarso Ria 
Published: November 2022

Penelitian ini bertujuan untuk: (1) mengetahui metode lompat berirama (lompat ritmik) dapat meningkatkan hasil belajar lompat jangkit, dan (2) mencari bukti-bukti bahwa metode lompat ritmik dapat meningkatkan hasil belajar lompat jangkit peserta didik kelas XI AK. 4 (akuntansi 4) SMK Negeri 2 Purworejo. Jenis penelitian adalah penelitian tindakan kelas (PTK). Subjek penelitian ini adalah 31 peserta didik kelas XI AK 4 SMK Negeri 2 Purworejo semester kedua tahun pelajaran 2013/2014. Penelitian ini terdiri atas tiga siklus, yang masing-masing terdiri dari tiga kali, dua kali, dan dua kali pertemuan. Analisis data menggunakan statistik deskriptif dengan mengkomparasikan data siklus I dengan siklus-siklus berikutnya. Hasil penelitian menunjukkan bahwa metode lompat ritmik meningkatkan hasil belajar lompat jangkit peserta didik kelas XI AK 4 SMK Negeri 2 Purworejo. Pada akhir siklus ketiga dicapai rata-rata nilai aspek spiritual sebesar 83,85, aspek sosial sebesar 96,00, aspek pengetahuan sebesar 70,484 dan aspek keterampilan sebesar 95,17. Peningkatan dampak penyerta berupa peningkatan aktivitas peserta didik, dan guru, dan keefektifan penggunaan alat/media.Kata Kunci: IMPROVING THE LEARNING OUTCOMES IN TRIPLE JUMP STUDENTS OF SMKN 2 PURWOREJO, THROUGH THE JUMP RHYTHMAbstractThis study aims to: (1) reveal whether the rhythmic jump method can improve the learning outcomes, and (2) discover the evidence that the rhythmic jump method can improve the learning outcomes in triple jump of XI AK. 4 SMK Negeri 2 Purworejo.This research is classroom action research (CAR). The subject was 31 students of class XI of the Accounting Departement of SMK Negeri 2 Purworejo in 2013/2014 in second semester. This classroom action research consisted of three cycles, each consisting of three, two, and two meetings subsequently.The data collection was performed by two collaborators and a cameraman using a handycam. The data analysis used the descriptive statistics by comparing the data in cycles I, II, and III. The results showed that the rhythmic jump method improves the learning outcomes of the students of class XI AK 4 SMK Negeri 2 Purworejo. In the third cycle, the average score of the spiritual aspect is 83.85, the social aspect 96.00, knowledge aspects 70.484 and skill aspect 95.17. The increasing impact of a concomitant increase is in the activity of the students, and teachers, and the effectiveness of the use of tools/media.Keywords : rhythmic jump method (rhythmic), triple jump
PENGEMBANGAN MODEL TES FISIK CALON ATLET TAEKWONDO USIA 11-13 TAHUN
Authors: Setiyawan Setiyawan , Sukadiyanto Sukadiyanto 
Published: November 2022

Penelitian ini bertujuan untuk menghasilkan model tes fisik calon atlet taekwondo yang valid dan reliabel berdasarkan indikator fisik taekwondo. Jenis penelitian ini adalah Research and Development (RD) dengan pendekatan survei melalui tes pengukuran. Hasil penelitian dan pengembangan berupa model tes fisik untuk calon atlet taekwondo usia 11-13 tahun. Teknik analisis data validitas menggunakan construct validity dengan korelasi Product Moment Pearson, Z skor untuk menyamakan satuan dan reliabilitas menggunakan test retest Conbrach’s Alpha dengan hasil reliabilitas panjang tungkai 1,00, kelentukan 0,992, kecepatan reaksi 0,639, kekuatan perut 0,604, power tungkai kanan 0,992, power tungkai kiri 0,998, kekuatan lengan 0,721 dan kelincahan 0,974. Hasil model tes fisik calon atlet taekwondo usia 11-13 tahun yang berupa norma dan buku panduan dapat digunakan sebagai pedoman pelatih dalam memilih bibit atlet taekwondo usia 11-13 tahun.Kata kunci: Model Tes Fisik, Taekwondo, Usia 11-13 Tahun DEVELOPING PHYSICAL MODEL TEST FOR PROSPECTIVE TAEKWONDO ATHLETE AGED 11-13 YEARSAbstractThis study aims to produce a model of a physical test of candidates taekwondo athlete which is valid and reliable based on physical indicators of taekwondo. This research is a Research and Development (RD) with survey approach through the test measurements. The result ofthis research and development is a model of a physical test for candidates of taekwondo athletes aged 11-13 years. The validity used construct validity with Product Moment Pearson correlation, Z scores were used to equalize unit and reliability used test retest Conbrach’s Alpha reliability resulting limb length as 1.00, flexibility 0.992, speed of reaction of 0.639, streght of abdominal 0.604, right leg power 0.992, left leg power 0.998, arms streght 0.721 and agility 0.974. The results of the physical tests models of taekwondo athletes candidate 11-13 years of age in the form of norms and guide books can be used as a guide in selecting taekwondo athletes aged 11-13 years.Keywords: Physical test models, Taekwondo, Age 11-13 Years
Pengembangan model pembelajaran kolary untuk permainan bola basket di sekolah menengah atas
Authors: Shidiq Abdul ‘Aziz Purnomo , Sukarmin Yustinus 
Published: November 2022

Tujuan penelitian ini adalah untuk menghasilkan model pembelajaran kolary untuk permainan bola basket di SMA. Pendekatan yang dilakukan dalam penelitian ini adalah penelitian dan pengembangan. Subjek penelitian ini adalah peserta didik sekolah menengah atas kelas X. Uji coba skala kecil dilakukan terhadap 32 peserta didik SMA N 1 Kartasura, dan 30 peserta didik SMA N 2 Sukoharjo. Uji coba skala besar dilakukan terhadap 32 peserta didik SMA N 1 Boyolali, 33 peserta didik SMA N 1 Banyudono, dan 36 peserta didik SMA N 2 Boyolali. Uji keefektifan dilakukan terhadap 32 peserta didik SMA N 7 Surakarta. Instrumen pengumpulan data yang digunakan yaitu: (1) pedoman wawancara, (2) pedoman observasi pembelajaran, dan (3) GPAI. Teknik analisis data yang dilakukan yaitu analisis deskriptif kuantitatif dan analisis deskriptif kualitatif. Hasil penelitian ini berupa model pembelajaran kolary untuk permainan bola basket di SMA. Dari hasil penilaian para ahli dan praktisi, model pembelajaran kolary memiliki validitas 0,988 sehingga dapat ditarik kesimpulan bahwa model pembelajaran kolary yang disusun dapat meningkatkan keterampilan dribbling, passing, dan shooting dan aspek afektif yang terdiri atas kerja sama, disiplin, dan sportif. Di samping itu, model pembelajaran kolary juga sangat sesuai dengan karakteristik, pertumbuhan, dan perkembangan peserta didik serta mampu membuat peserta didik lebih mudah untuk mempelajari teknik dasar permainan bola basket di SMA. Developing kolary instructional model for a basketball game in senior high school Abstract: The purpose of this study is to produce the kolary instructional model for a basketball game in senior high school. The approach taken in this study was research and development. The subjects were the tenth grade of high school. The preliminary field test was conducted on 32 students of the X grade in SMA N 1 Kartasura and 30 students of the X grade students of SMA N 2 Sukoharjo. The preliminary field test was conducted on 32 students of SMA N 1 Boyolali, 33 students of SMA Negeri 1 Banyudono, and 36 students of SMA N 2 Boyolali. The evaluation of the effectiveness was conducted on 32 students of SMA N 7 Surakarta. The data collection instruments used were: (1) interview (2) observation learning guide, and (3) GPAI. The data were analyzed using quantitative descriptive analysis and qualitative descriptive analysis. The results of this research were a learning model kolary for the game of basketball in high school. From the results of the assessment experts and practitioners' learning model kolary has a validity of 0,988 it could be concluded that the learning model kolary was drafted to improve the skills of dribbling, passing, and shooting and affective aspects consisting of operation, discipline, and sportsmanship. The learning models kolary in accordance with the characteristics and growth and development of students and students are able to make it easier to learn the basic techniques of basketball in high school.
Pengaruh volume latihan dan kecepatan reaksi terhadap ketepatan pukulan drive tenis meja atlet junior
Authors: Alamsyah Lefri , Tomoliyus Tomoliyus 
Published: November 2022

Penelitian untuk mengetahui: (1) perbedaan pengaruh volume latihan terhadap pukulan drive, (2) perbedaan pengaruh kecepatan reaksi terhadap pukulan drive, dan (3) interaksi antara volume latihan dan kecepatan reaksi terhadap ketepatan pukulan drive. Metode eksperimen faktorial 2x2. Populasi adalah atlet tenis meja junior. Jumlah sampel 20 orang diambil dengan teknik Random Sampling. Instrumen kecepatan reaksi menggunakan ruler drop test, untuk pukulan drive adalah tes oleh Tomoliyus (2012). Teknik analisis data menggunakan ANOVA dua jalur signifikan α = 0,05. Hasil menunjukkan: (1) ada perbedaan pengaruh volume latihan terhadap pukulan drive, p = 0,000 0,05, volume rendah lebih baik dibandingkan volume tinggi, (2) ada perbedaan pengaruh kecepatan reaksi terhadap pukulan drive, p = 0,000 0,05, kecepatan reaksi tinggi lebih baik dibandingkan rendah, dan (3) ada interaksi antara volume latihan dan kecepatan reaksi terhadap pukulan drive, p = 0,013 0,05. The effect of exercise volume and reaction speed on drive accuracy in junior table tennis Abstract: This research is to find out: (1) whether the difference in the exercise volume effect the increased drive. (2) the difference between low and fast speed reaction effect to drive service accuracy, and (3) the interaction between exercise volume and reaction speed to drive. This research experiments with a 2x2 factorial design. The sample is 20 persons which were taken by random sampling. The instrument for measuring reaction speed is a ruler drop test, drive service accuracy used drive accuracy ability instrument at table tennis game by Tomoliyus (2012). Data analysis used two paths ANOVA in level significance α = 0.05. The result showed: (1) there are different effects of exercise volume on drive accuracy. It is proved by p-value = 0.000 0.05, low volume are better than high volume. (2) There are differences between low and high reaction speed’s effect on drive service accuracy, it is proved by p value= 0.000 0.05, High reaction speed athletes are better than low reaction speed (3) There is an interaction between exercise volume and reaction speed toward drive service accuracy ability, it is proved by p-value = 0.013 0.05.
Pengembangan model pembelajaran terpadu tematik untuk sekolah dasar
Authors: Noor Ahmad Latif , Tomoliyus Tomoliyus 
Published: November 2022

Penelitian ini bertujuan untuk menghasilkan model pembelajaran terpadu tematik bagi siswa sekolah dasar kelas satu, yang dapat digunakan oleh guru dalam melaksanakan pembelajaran untuk siswa sekolah dasar kelas satu. Hasil penelitian berupa buku berjudul “Bermain Lempar Tangkap Bola”. Buku memuat pemanasan berupa permainan menjalaikan, inti terdiri atas 4 fase yaitu: (1) memasukkan bola ke dalam kardus; (2) pass and run with defender; (3) kucing-kucingan dengan bergeser; (4) Game lempar tangkap bola, dan diakhiri penutup berupa cooling down dan evaluasi. Berdasarkan penilaian ahli model secara isi materi sangat baik, bahasa sangat baik, format penulisan baik dan sesuai dengan karakteristik siswa sekolah dasar. Model pembelajaran terpadu tematik ini juga mampu untuk meningkatkan kemampuan kognitif, keterampilan gerak dasar (motorik) danafektif. Developing a thematically integrated learning model in elementary school Abstract: This study aims to produce a thematically integrated learning model for elementary school students keys one, which can be used by teachers in the teaching and learning process for elementary school students in grade one. The result of the research is a book entitled " play throwing and catching the ball." This book includes Warming up a game of catching fish, the core comprises four phases: (1) putting the ball into the box; (2) passing and running with the defender; (3) cat and mouse with a scroll; (4) Game throwing and catching the ball. Based on an expert assessment of this model the content of the material is very good, in the language, good writing format and in accordance with the characteristics of elementary school students. The thematically integrated learning model is also can be used to improve cognitive ability, basic movement skills (motoric) and affective domain.
The Legal Consequences of Debtor Transfer Carried out under the Agreement, House Ownership Loans
Authors: Wesna Putu Ayu Sriasih , Jusarata Ida Bagus Dwi , Kosasih Johannes Ibrahim 
Published: November 2022

Mortgage agreements often find cases, including the transfer of rights to the mortgage object, namely the house, which is carried out under the hands of the debtor to another party before the mortgage is paid off without the knowledge of the bank. This research aims to examine the validity of the house sale and purchase agreement on house ownership loans (KPR), through the debtor transfer process and to examine the legal consequences of the transfer of debtors carried out under the hands of a mortgage agreement, and also to examine the efforts have been taken by the bank to overcome it. This research used normative legal research. The results of this research showed that the transfer of debtors in general can occur with the knowledge of the bank and without the knowledge of the bank (under the hands). It can be concluded that the debtor transfer process is a form of sale and purchase agreement made between the old debtor, who is still bound by the bank credit agreement, and the new debtor. The process of transferring debtors legally must be carried out between three parties, namely the bank, the old debtor and the new debtor. The debtor transfer process must meet the requirements for a valid credit agreement, which is based on Article 1320 of the Civil Code. If there is a transfer of the debtor without the knowledge of the bank, legal remedies must be taken by the new debtor by filing a lawsuit against the old debtor and the bank to the District Court. This decision from the District Court which has permanent legal force (inkracht) is evidence of the existence of an agreement between the old debtor and the new debtor, and can be the basis for the bank to submit certificates and other documents to the new debtor. In order to avoid problems in the future, people who want to transfer debtors to mortgages can do so after obtaining approval from the bank as creditor.
Impikasi Pelaksanaan Upacara Ngaben (Pitra Yadnya) Saat Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) Akibat Pandemi Covid-19 di Provinsi Bali
Authors: Perbawa Kt. Sukawati Lanang P. , Nugraha Putu Wisnu , Juliant Lis 
Published: November 2022

Pandemi covid 19 membawa dampak yang sangat luas terhadap kehidupan masyarakat, khususnya berkaitan dengan upacara adat di Bali. Salah satu kegiatan tersebut adalah Upacara Ngaben (Pitra Yadnya). Disisi lain PPKM telah menjadi kebijakan Pemerintah Indonesia untuk memerangi pandemi Covid-19 sejak awal tahun 2020. PPKM memiliki pengaruh yang besar dalam upacara ngaben. Ngaben merupakan upacara menyucikan roh dan peleburan mayat dengan cara membakar mayat orang yang telah meninggal. Rumusan masalah dalam penelitian ini; Bagaimana peran hukum dalam pelaksanaan upacara ngaben di bali? dan bagaimana penggunaan sanksi terhadap masyarakat yang melanggar PPKM saat upacara ngaben di bali? Pendekatan penelitian ini, dengan perundang-undangan, tipe penelitian yang digunakan adalah penelitian hukum normatif. Teknik pengumpulan bahan hukum yang digunakan dalam penulisan ini adalah melalui studi kepustakaan. Adapun simpulan dari rumusan masalah adalah peran hukum dan sanksi terhadap pelanggar PPKM dalam kaitan dengan upacara ngaben yaitu sesuai ketentuan yang berlaku, seperti ; Intruksi Menteri Dalam Negeri Nomor 35 tahun 2021 dan Surat Edaran Gubernur Nomor 12 Tahun 2021.
ANALISIS PRODUKTIVITAS PONDASI TIANG PANCANG PROYEK PEMBANGUNAN GEDUNG SMKN KEHUTANAN PEKANBARU
Authors: Lidya Birahmatika  , Winayati  , Fitridawati Soehardi  
Published: November 2022

Proyek pembangunan komplek gedung SMKN Kehutanan pekanbaru, direncanakan dengan 330 hari kalender dalam setiap pekerjaan perlu dilakukan analisis produktivitas agar mengetahui tingkat produktivas sehingga pekerjaan dapat berjalan dengan waktu yang telah di rencanakan langkah awal sebuah bangunan adalah pekerjaan pondasi, kendala cuaca, mesin pancang, serta akses lokasi yang rusak, penggunaan metode time study atau mengetahui waktu dipilih menganalisis produktivitas. Penelitian dilakukan dengan cara mengumpulkan data berdasarkan observasi dilapangan untuk mendapatkan data-data yang dibutuhkan untuk menganalisis produktivitas pekerjaan pondasi tiang pancang serta perbandingan dengan nilai indeks analisa harga satuan pekerjaan pada Standar Nasional Indonesia tahun 2016 yang mengacu pada Peraturan Menteri Pekerjaan Umum dan Perumahan Rakyat nomor 28/PRT/M/2016 (Indeks Nasional) tentang koefisien pekerjaan pondasi tiang pancang. Pengamatan dilakukan selama waktu durasi pekerjaan pondasi pemancangan tiang pancang yaitu 5 hari kerja mulai tanggal 8, 9, 10, 12, dan 15 Maret 2021. Berdasarkan analisis yang telah dilakukan maka dapat ditarik kesimpulan bahwa nilai indeks lapangan terendah didaperoleh pada pelaksanaan pekerjaan pemancangan tanggal 15 Maret 2021 yaitu sebesar 0.010 untuk produktivitas tertinggi diperoleh pada tanggal 9 Maret 2021 dengan nilai produktivitas 0.056. Sehingga diperoleh total nilai indeks lapangan sebesar 0.1221 yang mempunyai selisih 0.0021 dari nilai indeks pekerjaan pondasi tiang pancang yang telah di tetapkan dalam indeks nasional yaitu sebesar 0.1200.