bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial disorders: Understanding mitochondrial DNA point mutations and deletion syndromes
Authors: Heuer Beth , Seibert Diane C. 
Published: November 2022

ABSTRACT
Mitochondrial disorders arise from DNA mutations in either the mitochondrial DNA (mtDNA) or nuclear DNA genomes. This article focuses on a mtDNA base-pair mutation associated with neuropathy, ataxia, and retinitis pigmentosa and Leigh syndrome and the large-scale mtDNA deletion associated with Kearns–Sayre syndrome. Disease sequelae and management strategies are reviewed, along with implications for the nurse practitioner in primary or specialty care.
Sex-related short-term blood pressure variability differences in kidney transplant recipients
Authors: Korogiannou Maria , Alexandrou Maria-Eleni , Sarafidis Pantelis , Pella Eva , Theodorakopoulou Marieta P. , Xagas Efstathios , Argyris Antonis , Protogerou Athanase , Boletis Ioannis N. , Marinaki Smaragdi 
Published: November 2022

Objective
Kidney transplant recipients (KTRs) display higher cardiovascular morbidity and mortality than the general population. Increased short-term blood pressure variability (BPV) is associated with a higher risk of adverse cardiovascular outcomes in chronic kidney disease (CKD). The aim of this study is to investigate sex differences in short-term BPV in KTRs.

Methods
In total, 136 male and 69 female KTRs with valid 24 h ambulatory blood pressure monitoring were included in this analysis. Systolic and diastolic BPV indices [SD, weighted SD (wSD), coefficient of variation (CV), average real variability (ARV) and variability independent of the mean (VIM)] were calculated with validated formulas for the 24 h, daytime and nighttime periods.

Results
Age, time from transplantation surgery and history of major comorbidities did not differ between men and women. During the 24-h period, systolic BPV indices did not differ between men and women (SBP-ARV: 9.4 ± 2.2 vs. 9.9 ± 2.5; P = 0.212). During the daytime period, SBP-CV and SBP-VIM were significantly higher in females compared with male participants (SBP-CV: 9.9 ± 2.4 vs. 11 ± 3.1%; P = 0.022 and SBP-VIM: 12.6 ± 3.0 vs 14.2 ± 3.9; P = 0.008); daytime SBP-SD and SBP-ARV, and all studied indexes during nighttime did not differ between groups. No significant between-group differences in 24 h and daytime diastolic BPV indices were detected. Nighttime DBP-CV was marginally higher in men (12.0 ± 3.6 vs. 11.4 ± 4.0; P = 0.053); the rest nighttime diastolic BPV indices measured were also nonsignificantly higher in men.

Conclusion
In conclusion, 24-h systolic and diastolic BPV parameters did not differ between male and female KTRs, but short-term BPV over the respective day- and nighttime periods showed different trends in men and women. Further studies are needed to examine possible differences in long-term BPV in KTRs.
Angiographic and clinical outcomes in patients with versus without diabetes mellitus after revascularization with BioMime sirolimus-eluting stent
Authors: Yun Hae Eun , Ki You-Jeong , Kim Weon , Kim Su Hyun , Kim Kyung Hwan , Lee Ming Gu , Lim Yeong Min , Kim Jae Min , Kang Won Yu , Kwon In Young , Cha So Young , Cho Jang Hyun 
Published: November 2022

Introduction
Drug-eluting stents (DES) significantly improved angiographic and clinical outcomes compared with bare-metal stents in patients with diabetes. The clinical effects of BioMime sirolimus-eluting stent (SES) in patients with diabetes have not been evaluated. Therefore, we compared the efficacy of BioMime DES in coronary artery disease (CAD) patients with versus without diabetes.

Methods
This prospective analytical study compared angiographic in-segment late loss and clinical effectiveness of BioMime SES stents in treating patients with (patients: 77 and lesions: 83) versus without (patients: 154 and lesions: 162) diabetes. The purpose of this study was the comparison of angiographic in-segment late loss at 12 months. Major adverse cardiac events (MACEs) were also monitored as secondary outcomes 24 months after the index procedure.

Results
Of 231 patients enrolled in the study, the mean age was 63.3 years and 153 patients were male. Angiographic follow-up rate was 84.8% (patients: 196) and intravascular ultrasound (IVUS) follow-up rate was 67.9% (patients: 157) at 12 months. Diabetic patients were comparable to nondiabetic patients for 12-month in-segment late loss (0.01 ± 0.31 mm for the nondiabetes group versus 0.04 ± 0.11 mm for the diabetes group; P = 0.158; P < 0.05). At 24 months, MACEs, including death, myocardial infarction and ischemic-driven target lesion revascularization were not statistically different between the two treatment groups.

Conclusions
BioMime SES stents in treating patients with diabetes were comparable in reducing angiographic restenosis at 12 months and MACEs at 24 months compared to nondiabetic patients with CAD.
Surgical Outcomes of Implant Versus Autologous Breast Reconstruction in Patients with Previous Breast-Conserving Surgery and Radiotherapy
Authors: Asaad Malke , Mitchell David , Murphy Brittany , Liu Jun , Selber Jesse C. , Clemens Mark W. , Bedrosian Isabelle , Butler Charles E. 
Published: November 2022

Background:
Post-mastectomy breast reconstruction in patients with a history of breast-conserving surgery (BCS) and radiotherapy is challenging with a paucity of literature on the outcomes of different breast reconstructive techniques. We hypothesized that implant-based breast reconstruction (IBR) would be associated with higher complication rates compared to either IBR combined with latissimus dorsi (LD) or free flap breast reconstruction (FFBR).

Methods:
We conducted a retrospective review of patients who underwent mastectomy with a prior history of BCS and radiotherapy between January 2000 and March 2016. Surgical and patient-reported outcomes (BREAST-Q) were compared between IBR vs. IBR/LD vs. FFBR.

Results:
We identified 9473 patients who underwent BCS and radiotherapy. Ninety-nine patients (105 reconstructions) met our inclusion criteria, 29% (n=30) of whom received IBR, 26% (n=27) IBR/LD, and 46% (n=48) received FFBR. Overall complication rate was not significantly different among the three groups (50% in IBR vs. 41% in IBR/LD vs. 44% in FFBR, p=0.77) while reconstruction failures were significantly lower in the FFBR group (33% in IBR vs. 19% in IBR/LD vs. 0% in FFBR, p<0.0001). The time between the receipt of radiotherapy and reconstruction was not a significant predictor of overall complications and reconstruction failure. No significant differences were identified between the three study cohorts in any of the three studied BREAST-Q domains.

Conclusion:
In patients with prior BCS and radiotherapy, FFBR was associated with lower probability of reconstruction failure compared to IBR but no significant difference in overall and major complication rates. The addition of LD flap to IBR did not translate into lower complication rates but may result in decreased reconstruction failures.
A circulating proteome-informed prognostic model of COVID-19 disease activity that relies on routinely available clinical laboratories
Authors: Ma William , Soulé Antoine , Tremblay Karine , Rousseau Simon , Emad Amin 
Published: November 2022

AbstractA minority of people infected with SARS-CoV-2 will develop severe COVID-19 disease. To help physicians predict who is more likely to require admission to ICU, we conducted an unsupervised stratification of the circulating proteome that identified six endophenotypes (EPs) among 731 SARS-CoV-2 PCR-positive hospitalized participants in the Biobanque Québécoise de la COVID-19, with varying degrees of disease severity and times to intensive care unit (ICU) admission. One endophenotype, EP6, was associated with a greater proportion of ICU admission, ventilation support, acute respiratory distress syndrome (ARDS) and death. Clinical features of EP6 included increased levels of C-reactive protein, D-dimers, interleukin-6, ferritin, soluble fms-like tyrosine kinase-1, elevated neutrophils, and depleted lymphocytes, whereas another endophenotype (EP5) was associated with cardiovascular complications, congruent with elevated blood biomarkers of cardiovascular disease like N-terminal pro B-type natriuretic peptide (NT-proBNP), Growth Differentiation Factor-15 (GDF-15), and Troponin T. Importantly, a prognostic model solely based on clinical laboratory measurements was developed and validated on 903 patients that generalizes the EPs to new patients recruited across all pandemic waves (2020-2022) and create new opportunities for automated identification of high-risk groups in the clinic. Thus, this novel way to address pathogenesis that leverages detailed phenotypic information but relies on routinely available information in the clinic to favor translation may find applications in other diseases beyond COVID-19.
A rapid systematic review of the effect of The Daily Mile™on children’s physical activity, physical health, mental health, wellbeing, academic performance and cognitive function
Authors: Breslin Gavin , Hillyard Medbh , Brick Noel , Shannon Stephen , McKay-Redmond Brenda , McConnell Barbara 
Published: November 2022

AbstractBackgroundA minority of children in the United Kingdom meet the recommended physical activity guidelines. One initiative which has been introduced to try and increase the physical activity levels of school children is The Daily Mile™ (TDM). The aim of this review was to determine the effect of TDM on children’s physical activity levels, physical health, mental health, wellbeing, academic performance and cognitive function.MethodsSix databases were systematically searched from TDM’s inception (2012) to 30thJune 2022. Studies were included if they involved school-aged children (aged 4-12 years), taking part in TDM and measured at least one pre-defined outcome.ResultsThirteen studies were included from the 123 studies retrieved. Longer-term participation in TDM was found to increase moderate-to-vigorous physical activity and physical fitness. None of the studies reported a significant change in Body Mass Index or academic performance. An acute bout of TDM was not found to improve cognitive function, however one good-quality study reported that longer-term participation in TDM increased visual spatial working memory. There was evidence from one fair-quality design study that TDM can improve mental health in the short term. There were no significant effects on wellbeing, however scores on self-perceptions improved mainly for children with low baseline self-perceptions.ConclusionThere is evidence to show that TDM can increase physical activity and physical fitness. However, higher-quality research, with adequate participant randomisation and longer-term, post-intervention follow-up is needed to ensure that any changes accurately reflect the components of TDM and are sustained beyond an intervention time frame. Policy recommendations of TDM increasing PA levels in the short term are supported by the evidence in this review. However, long-term improvement on mental health, wellbeing, academic performance and cognitive function requires further good-to excellent quality research. Promisingly, several protocol articles that include randomised controlled trials with long term follow-up have been published. These higher-quality design studies may provide a stronger evidence-base on the effects of TDM on children’s health and should underpin future recommendations in public health policy.Systematic Review registrationPROSPERO CRD42022340303
Predicting nutritional status for women of childbearing age from their economic, health, and demographic features: A supervised machine learning approach
Authors: Khudri Md. Mohsan , Rhee Kang Keun , Hasan Mohammad Shabbir , Ahsan Karar Zunaid 
Published: November 2022

AbstractBackgroundMalnutrition imposes enormous costs resulting from lost investments in human capital and increased healthcare expenditures. There is a dearth of research focusing on the prediction of women’s body mass index (BMI), and the malnutrition outcomes (underweight, overweight and obesity) in developing countries. This paper attempts to fill out this knowledge gap by predicting the BMI and the risks of malnutrition outcomes for Bangladeshi women of childbearing age from their economic, health, and demographic features.MethodsData from the 2017-18 Bangladesh Demographic and Health Survey and a series of supervised machine learning (SML) techniques are used. Additionally, this study circumvents the imbalanced distribution problem in obesity classification by utilizing an oversampling approach.ResultsStudy findings demonstrate that support vector machine and k-nearest neighbor are the two best-performing methods in BMI prediction based on coefficient of determination (R2), root mean square error (RMSE), and mean absolute error (MAE). The combined predictor algorithms consistently yield top specificity, Cohen’s kappa, F1-score, and AUC in classifying the malnutrition status, and their performance is robust to alternative standards. The feature importance ranking based on several nonparametric and combined predictors indicates that socioeconomic status, women’s age, and breastfeeding status are the most important features in predicting women’s nutritional outcomes. Furthermore, the conditional inference trees corroborate that those three features along with the partner’s educational attainment and employment significantly predict malnutrition risks.ConclusionTo the best of our knowledge, this is the first study that predicts BMI and one of the pioneer studies to classify all three malnutrition outcomes for women of childbearing age in Bangladesh, let alone in any lower-middle income country, using SML techniques. Moreover, in the context of Bangladesh, this paper is the first to identify and rank features that are critical in predicting nutritional outcomes using several feature selection algorithms. The estimators from this study predict the outcomes of interest most accurately and efficiently compared to other existing studies in the relevant literature. Therefore, study findings can aid policymakers in designing policy and programmatic approaches to address the double burden of malnutrition among Bangladeshi women, thereby reducing the country’s economic burden.
Labor resource allocation under extremely short construction period based on the inverse optimization method
Authors: Peng Junlong , Liu Xiang-Jun 
Published: November 2022

PurposeThis research is aimed to mainly be applicable to expediting engineering projects, uses the method of inverse optimization and the double-layer nested genetic algorithm combined with nonlinear programming algorithm, study how to schedule the number of labor in each process at the minimum cost to achieve an extremely short construction period goal.Design/methodology/approachThe method of inverse optimization is mainly used in this study. In the first phase, establish a positive optimization model, according to the existing labor constraints, aiming at the shortest construction period. In the second phase, under the condition that the expected shortest construction period is known, on the basis of the positive optimization model, the inverse optimization method is used to establish the inverse optimization model aiming at the minimum change of the number of workers, and finally the optimal labor allocation scheme that meets the conditions is obtained. Finally, use algorithm to solve and prove with a case.FindingsThe case study shows that this method can effectively achieve the extremely short duration goal of the engineering project at the minimum cost, and provide the basis for the decision-making of the engineering project.Originality/valueThe contribution of this paper to the existing knowledge is to carry out a preliminary study on the relatively blank field of the current engineering project with a very short construction period, and provide a path for the vast number of engineering projects with strict requirements on the construction period to achieve a very short construction period, and apply the inverse optimization method to the engineering field. Furthermore, a double-nested genetic algorithm and nonlinear programming algorithm are designed. It can effectively solve various optimization problems.
The takeover market’s effect on managerial ownership: evidence from hostile takeover susceptibility
Authors: Chatjuthamard Pattanaporn , Kijkasiwat Ploypailin , Jiraporn Pornsit , Uyar Ali 
Published: November 2022

Purpose
Capitalizing on a unique measure of takeover susceptibility principally based on the staggered implementation of state laws, this study aims to explore the takeover market’s effect on managerial ownership. The market for corporate control, often known as the takeover market, is an important external governance mechanism, whereas managerial ownership is a vital internal governance instrument. Managerial ownership brings into convergence the interests of shareholders and managers. The originality of this study arises from the usage of state-level anti-takeover legislations as a measure which is beyond the control of firms and plausibly exogenous to firm-specific characteristics.

Design/methodology/approach
In addition to the standard regression analysis, this study also executes a variety of robustness checks to minimize endogeneity, i.e. propensity score matching, entropy balancing, instrumental–variable analysis, Lewbel’s (2012) heteroscedastic identification and Oster’s (2019) testing for coefficient stability.

Findings
Based on a large sample of US firms, the results show that more hostile takeover threats bring about significantly lower managerial ownership. The results reinforce the prediction of the substitution hypothesis. The disciplinary function of the takeover market reduces agency conflict to the point where managerial ownership is less necessary as a governance mechanism. Specifically, a rise in takeover susceptibility by one standard deviation diminishes managerial ownership by 7.22%.

Originality/value
`To the best of the authors’ knowledge, this study is the first to shed light on the impact of the takeover market on managerial ownership using a novel measure mainly based on the staggered adoption of state laws, which are plausibly exogenous to individual firms’ characteristics. Consequently, unlike prior research, this study is more likely to indicate a causal effect, rather than merely a correlation.
Conflicting logics of the postpandemic university
Authors: Reisinger Gerald , Gaisch Martina 
Published: November 2022

Purpose
The purpose of this paper is to present a conceptual frame for scholars who draws on the conflicting logics of the postpandemic university.

Design/methodology/approach
This feature paper is based on a systematic review of research and studies conducted in the field of higher education. It illustrates broader trends with respect to how the various elements of contemporary and conflicting challenges present themselves within higher education institutions (HEIs).

Findings
A combination of literature review and fieldwork across a broad range of scientific fields presents a potentially powerful means of reducing the gap between research and practice. For this reason, this paper sets out to provide conceptual perspectives as to contemporary and conflicting challenges in higher education.

Research limitations/implications
This paper presents many descriptive results from HEIs in the western world which do not allow for making global inferences toward the entire higher education sector.

Practical implications
The results have a number of implications for the postpandemic university. Among them are that HEIs should not only be more open toward contemporary changes but also embrace previously excluded student populations with their purpose-driven and sustainable orientation toward life.

Originality/value
This paper presents a conceptual contribution to contemporary challenges in higher education as a way of refraining from one-size-fits-all approaches. It demonstrates how institutional positioning and profiling depend on conflicting logics. Consequently, each institution of higher learning needs to address these challenges in line with their strategic, economic and political settings.
Tumultuous waters and turbulent times: JEDI, humanities, and intellectual leadership in American higher education
Authors: Christensen Nicolette DeVille 
Published: November 2022

Purpose
This study aims to raise the issue of the president as the intellectual leader of the university in that they are the voice of the importance of the Humanities, both in inclusion and diversity measures, in decolonizing the curriculum and recognizing the importance of teaching life skills to students.

Design/methodology/approach
Discussion focuses on unrealistic workloads of university and college presidents which have engendered a move away from the president as central to the academic mission. It is drawn from the author's 30 years of service in senior leadership posts at institutions, very diverse in their scope, size and mission.

Findings
No matter how much data is produced in support of the importance of the Humanities to the mission of the undergraduate degree, support continues to decline. Because we are all enmeshed in the sound bite approach, perhaps we can take back the narrative through organizations, social media outlets, but mostly to install presidents as the intellectual leadership of the institution.

Originality/value
The author’s perspectives are those having served a variety of institutions over time in senior-level positions, including vice-presidential support to presidents, but also from the experience of being a university president.
Change agents’ enactment of management control systems: shaping strategic change in a telecommunications organisation
Authors: Sharma Umesh , Lowe Alan 
Published: November 2022

PurposeThis paper aims to use a perspective informed by practice theory to examine the influence of change agents in enacting management control systems (MCS) in the process of shaping strategy.Design/methodology/approachThe research uses a case study approach to examine the implementation of a business strategy in the utility sector. The authors seek a better understanding of practice theory and its role in influencing institutional change and stability.FindingsThe case study findings show that the change agents enacted MCS practices that aided the metamorphosis of a once state-owned company into a for-profit enterprise. The findings show how the organisation transformed from a long-established preoccupation with technical systems and engineering and shifted to a focus on customer satisfaction and shareholder interests.Research limitations/implicationsIn terms of policy implications, bureaucrats need to appreciate that inculcating business norms is not an easy path and can be met with resistance, which creates delays in strategy implementation. The current study, while reporting some of the influences of tribal loyalty, was nevertheless limited by not having the time and space to examine in-depth the intersections of MCS and strategy within a strongly tribal context. This can be an avenue for future research.Practical implicationsThe study helps to understand embedded actors in the implementation of strategy by refocusing research on the actions and interactions of strategy implementation practitioners.Originality/valueThe authors contribute to the literature by seeking to use practice theory and offer a valuable understanding, from the actor level, of how practices are created and enacted. Often accounting studies have paid less attention to the change agents in the process of shaping business-oriented strategic activity. This study enabled us to gain a better understanding of the action and practice behaviour around the strategy-MCS nexus.