bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD8+ Tumor-Infiltrating Lymphocyte Abundance Is a Positive Prognostic Indicator in Nasopharyngeal Cancer
Authors: Shi Wei , Fijardo Mackenzie , Bruce Jeff P. , Su Jie , Xu Wei , Bell Rachel , Bissey Pierre-Antoine , Hui Angela B.Y. , Waldron John , Pugh Trevor J. , Yip Kenneth W. , Liu Fei-Fei 
Published: September 2022

Abstract

Purpose:
Tumor-infiltrating lymphocytes (TIL) are immune cell populations found within tumors, critical in the antigen-specific host immune response. In this study, we aimed to elucidate the prognostic significance of CD3+, CD4+, and CD8+ TILs in nasopharyngeal cancer (NPC).

Experimental Design:
Immune cell infiltration was quantified in NPC samples (n = 50) using RNA-sequencing (RNA-seq) data based on rearranged T-cell receptor (TCR) reads and the Estimation of Stromal and Immune cells in malignant tumors using expression data (ESTIMATE) immune score tool. The differential abundances of TIL subset populations were also characterized through IHC staining of formalin-fixed, paraffin-embedded samples from a training cohort (n = 35), which was a subset of the RNA-seq cohort (n = 50).

Results:
In the RNA-seq cohort, patients with higher rearranged TCR reads experienced superior 5- and 10-year overall survival (OS; P &lt; 0.001), and disease-free survival (DFS; P &lt; 0.001). Similarly, patients with higher ESTIMATE immune scores experienced superior 5- and 10-year OS (P = 0.024) and DFS (P = 0.007). In the training cohort, high abundances of CD8+ TILs were significantly associated with improved 5- and 10-year OS (P = 0.003) and DFS (P = 0.005). These findings were corroborated in an independent validation cohort (n = 84), and combined analysis of the training and validation cohorts [n = 119 (35+84)], which further demonstrated improved 5- and 10-year survival in terms of locoregional control (P &lt; 0.001) and distant metastasis (P = 0.03).

Conclusions:
Taken together, our study highlights the prognostic value of CD8+ TILs in NPC, and the potential of future investigations into cellular-based immunotherapies employing CD8+ lymphocytes.
Intravenous Thrombolysis With Alteplase at 0.6 mg/kg in Patients With Ischemic Stroke Taking Direct Oral Anticoagulants
Authors: Okada Takashi , Yoshimoto Takeshi , Wada Shinichi , Yoshimura Sohei , Chiba Tetsuya , Egashira Shuhei , Kimura Shunsuke , Shiozawa Masayuki , Inoue Manabu , Ihara Masafumi , Toyoda Kazunori , Takashima Hiroshi , Koga Masatoshi 
Published: September 2022

Background
We elucidated the safety of treatment with alteplase at 0.6 mg/kg within 24 hours for patients on direct oral anticoagulants (DOACs) before ischemic stroke onset.

Methods and Results

Consecutive patients with acute ischemic stroke who underwent intravenous thrombolysis using alteplase at 0.6 mg/kg from 2011 to 2021 were enrolled from our single‐center prospective stroke registry. We compared outcomes between patients taking DOACs and those not taking oral anticoagulants within 48 hours of stroke onset. The primary safety outcome was the rate of symptomatic intracranial hemorrhage with a ≥4‐point increase on the National Institutes of Health Stroke Scale score from baseline. The efficacy outcome was defined as 3‐month modified Rankin Scale score of 0 to 2 after stroke onset. Of 915 patients with acute ischemic stroke who received intravenous thrombolysis (358 women; median age, 76 years; median National Institutes of Health Stroke Scale score, 10), 40 patients took DOACs (6 took dabigatran, 8 took rivaroxaban, 16 took apixaban, and 10 took edoxaban) within 24 hours of onset and 753 patients did not take any oral anticoagulants. The rate of symptomatic intracranial hemorrhage was comparable between patients on DOACs and those not on oral anticoagulants (2.5% versus 2.4%,
P
=0.95). The rate of favorable outcomes was comparable between the 2 groups (59.4% versus 58.2%,
P
=0.46), although the admission National Institutes of Health Stroke Scale score was higher in patients on DOACs. No significant differences showed in any intracranial hemorrhage within 36 hours or mortality at 3 months.

Conclusions
Intravenous thrombolysis would be safely performed for patients on DOACs following the recommendations of the Japanese guidelines.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02251665.
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
Authors: Beaty Elijah H. , Fernando Rohesh J. , Jacobs Marie L. , Winter Gillian G. , Bulla Catalina , Singleton Matthew J. , Patel Neel J. , Bradford Natalie S. , Bhave Prashant D. , Royster Roger L. 
Published: September 2022

Background
Methohexital and propofol can both be used as sedation for direct current cardioversion (DCCV). However, there are limited data comparing these medications in this setting. We hypothesized that patients receiving methohexital for elective DCCV would be sedated more quickly, recover from sedation faster, and experience less adverse effects.

Methods and Results

This was a prospective, blinded randomized controlled trial conducted at a single academic medical center. Eligible participants were randomly assigned to receive either methohexital (0.5 mg/kg) or propofol (0.8 mg/kg) as a bolus for elective DCCV. The times from bolus of the medication to achieving a Ramsay Sedation Scale score of 5 to 6, first shock, eyes opening on command, and when the patient could state their age and name were obtained. The need for additional medication dosing, airway intervention, vital signs, and medication side effects were also recorded. Seventy patients who were randomized to receive methohexital (n=37) or propofol (n=33) were included for analysis. The average doses of methohexital and propofol were 0.51 mg/kg and 0.84 mg/kg, respectively. There were no significant differences between methohexital and propofol in the time from end of injection to loss of conscious (1.4±1.8 versus 1.1±0.5 minutes;
P
=0.33) or the time to first shock (1.7±1.9 versus 1.4±0.5 minutes;
P
=0.31). Time intervals were significantly lower for methohexital compared with propofol in the time to eyes opening on command (5.1±2.5 versus 7.8±3.7 minutes;
P
=0.0005) as well as at the time to the ability to answer simple questions of age and name (6.0±2.6 versus 8.6±4.0 minutes;
P
=0.001). The methohexital group experienced less hypotension (8.1% versus 42.4%;
P
<0.001) and less hypoxemia (0.0% versus 15.2%;
P
=0.005), had lower need for jaw thrust/chin lift (16.2% versus 42.4%;
P
=0.015), and had less pain on injection compared with propofol using the visual analog scale (7.2±9.7 versus 22.4±28.1;
P
=0.003).

Conclusions
In this model of fixed bolus dosing, methohexital was associated with faster recovery, more stable hemodynamics, and less hypoxemia after elective DCCV compared with propofol. It can be considered as a preferred agent for sedation for DCCV.

Registration

URL:
https://www.clinicaltrials.gov/ct
; Unique identifier: NCT04187196.
Deferral of Coronary Revascularization in Patients With Reduced Ejection Fraction Based on Physiological Assessment: Impact on Long‐Term Survival
Authors: Gallinoro Emanuele , Paolisso Pasquale , Di Gioia Giuseppe , Bermpeis Kostantinos , Fernandez‐Peregrina Estefania , Candreva Alessandro , Esposito Giuseppe , Fabbricatore Davide , Bertolone Dario Tino , Bartunek Jozef , Vanderheyden Marc , Wyffels Eric , Sonck Jeroen , Collet Carlos , De Bruyne Bernard , Barbato Emanuele 
Published: September 2022

Background
Deferring revascularization in patients with nonsignificant stenoses based on fractional flow reserve (FFR) is associated with favorable clinical outcomes up to 15 years. Whether this holds true in patients with reduced left ventricular ejection fraction is unclear. We aimed to investigate whether FFR provides adjunctive clinical benefit compared with coronary angiography in deferring revascularization of patients with intermediate coronary stenoses and reduced left ventricular ejection fraction.

Methods and Results

Consecutive patients with reduced left ventricular ejection fraction (≤50%) undergoing coronary angiography between 2002 and 2010 were screened. We included patients with at least 1 intermediate coronary stenosis (diameter stenosis ≥40%) in whom revascularization was deferred based either on angiography plus FFR (FFR guided) or angiography alone (angiography guided). The primary end point was the cumulative incidence of all‐cause death at 10 years. The secondary end point (incidence of major adverse cardiovascular and cerebrovascular events) was a composite of all‐cause death, myocardial infarction, any revascularization, and stroke. A total of 840 patients were included (206 in the FFR‐guided group and 634 in the angiography‐guided group). Median follow‐up was 7 years (interquartile range, 3.22–11.08 years). After 1:1 propensity‐score matching, baseline characteristics between the 2 groups were similar. All‐cause death was significantly lower in the FFR‐guided group compared with the angiography‐guided group (94 [45.6%] versus 119 [57.8%]; hazard ratio [HR], 0.65 [95% CI, 0.49–0.85];
P
<0.01). The rate of major adverse cardiovascular and cerebrovascular events was lower in the FFR‐guided group (123 [59.7%] versus 139 [67.5%]; HR, 0.75 [95% CI, 0.59–0.95];
P
=0.02).

Conclusions
In patients with reduced left ventricular ejection fraction, deferring revascularization of intermediate coronary stenoses based on FFR is associated with a lower incidence of death and major adverse cardiovascular and cerebrovascular events at 10 years.
Cistercian Adventures in Glass
Authors: Koestlé-Cate Jonathan 
Published: September 2022

Abstract
Stained glass windows created by Jean-Pierre Raynaud and Pierre Soulages for the Abbeys of Noirlac and Conques employ a minimalistic style sensitive to their Romanesque contexts but also express qualities one might call Cistercian, even though only one of the commissions was created for an actual Cistercian abbey. As a form of monasticism, “Cistercian” signifies values of simplicity, poverty, and austerity presented by the founders of the Cistercian Order as essential to the monastic life and embodied in the rigor of their architecture. Natural light is a key element in Cistercian fenestration, differing significantly from the display of color associated with Gothic stained glass. I argue that a form of neo-Cistercianism is evident in and exemplified by the works of Raynaud and Soulages for their respective abbey commissions, in which an aesthetic of restraint and economy aims, above all, to treat the configuration of light as the primary consideration.
A new species of Pseudodiaptomus (Copepoda, Calanoida, Pseudodiaptomidae) from off Tanjung Merah, Bitung, North Sulawesi, Indonesia
Authors: Mulyadi  
Published: September 2022

Abstract
A new species of the demersal copepod genus Pseudodiaptomus is described from Sulawesi, Indonesia. This species is definitely assigned to the Nudus species group. Pseudodiaptomus kleini n. sp. is distinguishable in the female by the posterior corners of its Pdg5 with 3 spine-like processes, the symmetrical CR, the Ur1 without any processes, and the form of the P5; in the male by the Ur1 naked, and the form of the P5.
Complementary description and record of Peltidium perturbatum Geddes, 1968 (Copepoda, Harpacticoida, Peltidiidae) from the Northwestern Tropical Atlantic
Authors: Suárez-Morales Eduardo 
Published: September 2022

Abstract
During a survey of the zooplankton community of a protected coastal system on the Caribbean coast of Mexico, several adult females and immature individuals of the usually benthic or epiphytic harpacticoid copepod genus Peltidium, were recovered; they were identified as the Bahamian species P. perturbatum Geddes, 1968. This species has not been recorded from other areas of the Northwestern Tropical Atlantic (NWTA) region after its original description. Based on the examination of the Mexican Caribbean material, a complementary description of this species is presented including new details of antennules, caudal rami, leg 1, and cuticular ornamentation by using SEM analysis. Its finding in the Mexican Caribbean represents the southernmost record of the genus in the Americas and the first record for the Mexican copepod fauna. A key to the known species of the genus in the NWTA is also provided.
Performance of New Near-Real-Time PERSIANN Product (PDIR-Now) for Atmospheric River Events over the Russian River Basin, California
Authors: Afzali Gorooh Vesta , Shearer Eric J. , Nguyen Phu , Hsu Kuolin , Sorooshian Soroosh , Cannon Forest , Ralph Marty 
Published: September 2022

Abstract
Most heavy precipitation events and extreme flooding over the U.S. Pacific coast can be linked to prevalent atmospheric river (AR) conditions. Thus, reliable quantitative precipitation estimation with a rich spatiotemporal resolution is vital for water management and early warning systems of flooding and landslides over these regions. At the same time, high-quality near-real-time measurements of AR precipitation remain challenging due to the complex topographic features of land surface and meteorological conditions of the region: specifically, orographic features occlude radar measurements while infrared-based algorithms face challenges, differentiating between both cold brightband (BB) precipitation and the warmer nonbrightband (NBB) precipitation. It should be noted that the latter precipitation is characterized by greater orographic enhancement. In this study, we evaluate the performance of a recently developed near-real-time satellite precipitation algorithm: Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks (PERSIANN) Dynamic Infrared–Rain Rate-Now (PDIR-Now). This model is primarily dependent on infrared information from geostationary satellites as input; consequently, PDIR-Now has the advantage of short data latency, 15–60-min delay between observation to precipitation product delivery. The performance of PDIR-Now is analyzed with a focus on AR-related events for cases dominated by NBB and BB precipitation over the Russian River basin. In our investigations, we utilize S-band (3-GHz) precipitation profilers with Joss/Parsivel disdrometer measurements at the Middletown and Santa Rosa stations to classify BB and NBB precipitation events. In general, our analysis shows that PDIR-Now is more skillful in retrieving precipitation rates over both BB and NBB events across the topologically complex study area as compared to PERSIANN-Cloud Classification System (CCS). Also, we discuss the performance of well-known operational near-real-time precipitation products from 2017 to 2019. Conventional categorical and volumetric categorical indices, as well as continuous statistical metrics, are used to show the differences between various high-resolution precipitation products such as Multi-Radar Multi-Sensor (MRMS).
Psychiatric Treatment and Repeat Suicide Attempts Among Adults With Substance Use, by HIV Status, United States, 2014-2020
Authors: Iqbal Shareen A. , Truman Benedict I. , Crosby Alex E. 
Published: September 2022

Objectives: The association among psychiatric treatment history, HIV, and suicide reattempts among people starting treatment for substance use is not well understood. The objective of this study was to describe, by HIV status, the risk and protective factors associated with suicide reattempts among adults seeking treatment for substance use. Methods: The study included 340 390 US adult residents aged ≥18 years in the Addiction Severity Index–Multimedia Version network from January 1, 2014, through December 31, 2020. We used adjusted logistic regression models to estimate strength of association between prior psychiatric treatment, HIV status, and sociodemographic factors and suicide reattempts within 30 days of treatment evaluation. Results: Adults who had been prescribed psychiatric medication were less likely to have a recent suicide reattempt (adjusted odds ratio [aOR] = 0.8; 95% CI, 0.7-0.8) than adults with no prescription history. Adjusted models found similar protective effects between psychiatric treatment and suicide reattempts among adults reporting abuse, mental illness, injection drug use, and limited activity because of a medical condition. Conversely, the following were associated with recent suicide reattempts: being male (aOR = 1.4; 95% CI, 1.3-1.5), having a high school education/GED (General Educational Development) or less (aOR = 1.2; 95% CI, 1.1-1.2), being single (aOR = 1.2; 95% CI, 1.1-1.3), experiencing a pain problem (aOR = 1.2; 95% CI, 1.2-1.3), and not being referred to substance use treatment by court (aOR = 3.4; 95% CI, 3.2-3.7). Conclusions: A history of prescribed psychiatric medication is significantly associated with a reduced risk for suicide reattempts among adults seeking substance use treatment. Clinicians should consider incorporating mental health and suicide assessments into substance use treatment plans.
Place, Violence, and Resistance: Impacts of Mining in the Chilean Andes
Authors: Carrasco Anita 
Published: September 2022

The indigenous community of Estación San Pedro has turned a sense of place into an act of resistance to the impacts of mining on its homeland in the Chilean Andes. In 2007 San Pedrinos wrote to the headquarters of Chile’s National Copper Corporation claiming compensation for historical dispossession of water, forced migration from their homeland, and the disintegration of their traditional way of life. San Pedrinos continue to return to their homeland despite the mining corporation’s historical attempts to obliterate them. La comunidad indígena de Estación San Pedro ha convertido su sentido de lugar en un acto de resistencia ante los impactos de la minería en su tierra natal, localizada en los Andes chilenos. En 2007, los san pedrinos escribieron a la sede de la Corporación Nacional del Cobre de Chile exigiendo una compensación por el despojo histórico de agua, la migración forzada de su lugar natal y la desintegración de su forma de vida tradicional. Los san pedrinos continúan regresando a su tierra natal a pesar de los intentos históricos de la corporación minera por destruirlos.
The best structure of the Tampa Scale for Kinesiophobia for patients with chronic low back pain has two domains and nine items
Authors: Pontes-Silva André , Dibai-Filho Almir Vieira , Costa de Jesus Sulamizia Filomena , Santos de Oliveira Leonardo Antônio , Bassi-Dibai Daniela , Fidelis de Paula Gomes Cid André , Avila Mariana Arias 
Published: September 2022

Purpose To identify the best internal structure of the Tampa Scale for Kinesiophobia in chronic low back pain patients. Design Questionnaire validation study was designed for this study. Setting This study was conducted in physical therapy facility. Subjects Respondents reporting chronic low back pain (≥3 points on the 11-point Numerical Pain Rating Scale). Main measures We included participants of both sexes, with a self-report of low back pain ≥3 months and with pain intensity ≥3 on the 11-point Numerical Pain Rating Scale; participants also answered the Roland–Morris Disability Questionnaire and the Pain-Related Catastrophizing Thoughts Scale for low back pain disability and catastrophizing, respectively. The dimensionality and number of items of the Tampa Scale for Kinesiophobia were evaluated using the confirmatory factor analysis. Criterion validity was assessed using Spearman’s correlation coefficient using the original version of the 17-item Tampa Scale for Kinesiophobia as the gold standard. Results A total of 122 participants were included, with mean values of low back pain duration ≥48 months, pain intensity >5 and disability >8. Tampa Scale for Kinesiophobia structure with two domains and nine items was the most suitable, with adequate values in all fit indices (Chi-square/degree of freedom <3, Comparative Fit Index and Tucker–Lewis Index >0.90, and root mean square error of approximation <0.08) and lower Akaike information criterion and Bayesian information criterion values. We observed a high correlation between the 17-item Tampa Scale for Kinesiophobia and the activity avoidance domain (rho = 0.850, P < 0.001) and somatic focus domain (rho = 0.792, P < 0.001) of the nine-item Tampa Scale for Kinesiophobia. Conclusion Tampa Scale for Kinesiophobia structure with two domains (activity avoidance and somatic focus) and nine items is the most suitable for patients with chronic low back pain.
Training to Build Nutrition Capacity in the Nigerian Agricultural Sector: Initial Assessment and Future Directions
Authors: Adeyemi Olutayo , Phorbee Olapeju , Samuel Folake , Sanusi Rasaki , Afolabi Wasiu , Covic Namukolo , Onabolu Adeyinka , Ajieroh Victor 
Published: September 2022

Background: In response to calls to increase nutrition-sensitive agriculture (NSA), the Federal Ministry of Agriculture and Rural Development developed the Nigeria Agricultural Sector Food Security and Nutrition Strategy 2016-2025 (AFSNS). Capacity development activities to facilitate the AFSNS implementation subsequently commenced. Objective: This study analyzed the processes and outputs of initial capacity development efforts, examined findings from the analysis using existing literature, and identified critical next steps for nutrition capacity development in the Nigerian agriculture sector. Methods: The study reviewed documents including a proposal for nutrition training of agriculture sector actors, reports of meetings held among 6 resource persons who designed and/or delivered training, training reports, participants’ pre- and posttraining assessments, and participants’ training evaluation. Interviews were conducted with 2 resource persons involved in training design and delivery. Documents and interviews were coded and analyzed to identify emergent themes. Participants’ pre- and posttests results were compared using paired t test in Stata 12.0. Results: Knowledge and practice gaps were more extensive than had been anticipated. Training had some but limited effects on knowledge scores at the federal level. Modules addressing implementation practices had to be scaled down for participants to keep up with the learning pace. Existing literature indicates that such training would have been better planned as part of a broader sectoral nutrition workforce strategy, to facilitate greater tailoring of training to participants’ job roles. Conclusion: Effective AFSNS implementation requires developing and operationalizing a comprehensive short-, medium- and long-term Agriculture Sector Nutrition Capacity Development Strategy for Nigeria.
Highly conducting corn starch doped ionic liquid solid polymer electrolyte for energy storage devices
Authors: Konwar Subhrajit , Singh Abhimanyu , Singh Pramod K , Singh Ram Chandra , Rawat Suneyana , Dhapola Pawan Singh , Agarwal Daksh , Yahya MZA 
Published: September 2022

In this study, a new biopolymer electrolyte (BPE) is successfully developed using corn starch complexed with ammonium iodide (NH4I) as host, and low viscosity ionic liquid 1-Ethyl, 3-Methyl Imidazolium Thiocyanate (EMImSCN), as a plasticizer. This ionic liquid doped BPE shows high ionic conductivity of the order 10−4 S/cm and electrochemical stability window more than 3 V, which is suitable for electrochemical application. The ionic transference number (tion) of 0.98 confirms the system to be predominantly ionic in nature. Fourier transform infrared spectroscopy (FTIR) shows complex nature, while polarized optical microscopy (POM) gives us an idea about the semi-crystalline nature of BPE. Maximum conducting ionic liquid doped BPE sandwiched electric double layer capacitor (EDLC) and dye sensitize solar cell (DSSC) shows efficient performance.