bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication Administration Error Reporting Among Nurses: A Descriptive Qualitative Study
Authors: Tuvor Dzidefo , Kumah Augustine , Abiti Rebecca , Afakorzi Stephen Henry , Agbemade Peter K. , Ahiale Christine , Dzodzodzi Mac , Dogbedo Anthony Bless , Peter Worlasi Adanu , Obot Emmanuel , Tornyi Janet Mawunyo , Issah Abdul-Razak , Dzubey Innocent , Kanamitie Deborah Terkperkie 
Published: February 2025

ABSTRACT

Introduction
Nurses are integral to the healthcare delivery team (multidisciplinary team). They are involved and play vital roles with responsibilities to ensure the quality of healthcare for their patients. The key to those varied roles is the administration of medication. Depending on the clinical setting, nurses spend up to 40% of their hours on medication administration and its management processes. They are liable to identify and prevent medication administration errors (MAEs) and their consequences. This study aimed to explore the barriers and facilitators to the reporting behavior for MAEs among nurses in Ghana.

Methods
A descriptive qualitative cross-sectional study was conducted among nurses in a district catholic hospital in Ghana. The level of nurses’ knowledge of MAEs, causes of such errors, barriers to reporting, and strategies for minimizing errors were assessed. Purposive sampling was used to select a total sample of 20 nurses interviewed face-to-face using an in-depth method. The interviews were recorded, transcribed, and analyzed thematically.

Results
The study found that all nurses are aware of MAEs, which serve as the basis for decision-making. However, some nurses do not report these errors when they occur. Factors such as workload, stress and tiredness, staff shortage, difficulty calculating drug dosage, inadequate knowledge about specific medications, distractions during administration, and patient-related factors were identified as common causes of MAEs. The study also revealed that hospital management and the potential negative consequences of reporting errors, such as unpleasant reactions, lawsuits, and loss of a job, are significant barriers to reporting.

Conclusion
Regular training workshops should be conducted to update nurses’ knowledge about the importance of reporting medication errors, the reporting process, new medications and their administration, to develop a policy document that promotes a nonblaming, nonpunitive, and supportive learning culture for MAE medic reporting.
Occuli Dextra Proptosis in Symptomatic Hiperthyroidism with Diffuse Goitre in 45-Year-Old-Woman: A Case Report with Literature Review
Authors: Novitasari Diana 
Published: February 2025

Thyroid hormones have been shown to impact the uptake and transportation of iron. By binding to a functioning TSH receptor, which is present in erythrocytes and certain extrathyroidal organs, TSH may have an effect on hematopoiesis. There are common causes for both poor thyroid status and anemia, which could account for the co-occurrence of low thyroid function and anemia. We report the case of 45 -year-old woman with major complaints of Swelling on her neck. Swelling on this patient occur with palpitations. On local examination of the neck area, there was visible mass during inspection, and on palpation there mass in the neck area. On laboratory examination, TSHs levels were 5.6 uIU/mL, FT4 levels were 128pmol/L, Hemoglobin 7.7 µg/dL. The patient underwent oral theraphy with using Salmon DNA on her diet and after 1 month control Her lab turn out very well with TSHs levels were 4,1 uIU/mL, FT4 levels were 22 pmol/L, Hemoglobin 10 µg/dL.
FAILURE OF CORPORATE GOVERNANCE - A CASE STUDY AT PT GARUDA INDONESIA TBK
Authors: Yuniarwati  , Ardana I Cenik , Dermawan Elizabeth Sugiarto 
Published: February 2025

The topic of corporate governance became the focus of research, discussions, seminars and recent regulatory reforms following a wave of failures in implementing the governance of multinational companies in various countries. In Indonesia, PT Garuda Indonesia Tbk is a public company that has failed in implementing a good corporate governance system. The purpose of this study is to investigate the factors causing the failure of corporate governance. The research method uses a single case study. The research subject was PT Garuda Indonesia Tbk during the period 2018-2019. The results showed that the failure of the implementation of the corporate governance system at PT Garuda Indonesia Tbk was caused by the crisis of ethical leadership in almost all the highest ranks of the company. This study reinforces the findings of the latest researchers who revealed the absence of ethical leadership as a cause of failure in implementing corporate governance in various companies and emphasized the important role of ethical leadership in a business entity or organization.

Keywords: ethical leadership, corporate governance, case studies
MUSEQuBES: The Kinematics of O vi-bearing Gas in and around Low-redshift Galaxies
Authors: Dutta Sayak , Muzahid Sowgat , Schaye Joop , Cantalupo Sebastiano , Chen Hsiao-Wen , Johnson Sean 
Published: February 2025

Abstract
We present a detailed study of the kinematics of O vi-bearing gas around 60 low-mass (median

log
10

(

M
⋆

/

M
⊙

)

= 8.9) galaxies at low redshift (0.1 < z < 0.7) using background quasars (median impact parameter ≈115 kpc) as part of the MUSE Quasar-fields Blind Emitters Survey (MUSEQuBES). We find that the majority of the O vi absorbers detected within the virial radius have line-of-sight velocities smaller than the escape velocities and are thus consistent with being gravitationally bound, irrespective of the halo mass. However, the fraction of such absorbers declines at larger impact parameters. The Doppler b parameter and the velocity width (Δv
90) of the O vi absorbers exhibit large scatter inside the virial radius of the host galaxies, but the scatter declines sharply at impact parameter D ≳ 2R
vir. For high-mass galaxies (

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10

(

M
⋆

/

M
⊙

)

> 9), O vi absorption displays a larger kinematic spread, quantified by the pixel-velocity two-point correlation function (TPCF). However, the difference becomes marginal when the pixel velocities are scaled by the galaxies’ circular velocities. We do not find any significant difference between the TPCF of isolated and group galaxies when the stellar mass is controlled for. A significant fraction of groups (4/6) with four or more member galaxies do not show any detectable O vi absorption, likely due to the passive nature of the nearest galaxies.
Chromoblastomycosis is curable with DAT therapy (debulking, intralesional amphotericin B, oral terbinafine); case series of 16 patients
Authors: Ranawaka Ranthilaka R. , Abeywickrama Viharatennegedara 
Published: February 2025

Abstract:
Once incurable and chronic devastating diseases of chromomycosis is now curable with, debulking, intralesional amphotericin B and oral terbinafine (DAT). Debulking methods ranged from electrocautery to total surgical excision according to the size and the site of the lesion; a diluted solution of 1 mg/mL of amphotericin B (AMB) was injected weekly at the edge of the lesion; and simultaneous treatment with daily 500 mg oral terbinafine. Voriconazole 200 mg twice daily was added in one patient who had infection spread along the right lower limb for more than 20 years. DAT therapy was continued until complete clinical clearance where 14 out of 16 (87.5%) were cured using intralesional AMB 4–8 weeks (mean 5.8, mode 7) and oral terbinafine 6–12 weeks (mean 9.6, mode 12). Two patients who had lesions for 10 years and 20 years had to continue treatments for 14 weeks and 34 weeks, respectively, leaving scarring, chronic lymphedema, or depigmentation to a lesser degree. Early initiation of treatment gives an optimal outcome in a shorter period of time without residual sequelae.
Evaluating the anti-bacterial activities of potentized medicines on the clinical isolates from the urine samples
Authors: Gajjar Normi , Talele Gitanjali , Shah Gaurang B , Shah Rajesh 
Published: February 2025

Abstract:

BACKGROUND:
Our study explores nosodes (potentized medicines derived from microbes), as alternative antimicrobial measures against infections. Different nosodes were tested for efficacy against pathogens in clinical urine samples, comparing them with Gentamicin.

OBJECTIVE:
Evaluating the efficacy of potentized medicines against microbes found in urine samples.

MATERIALS AND METHODS:
The test samples were added to the sterile 96 well plates with 150 μL of sterile media followed by bacteria-positive clinical urine samples (10 μL), and the plate was incubated at 37°C. After 72 h, optical density was measured. Reduction in bacterial growth was calculated as the antibacterial potential of the drugs.

RESULTS:

Escherichia coli poly-nosode 100C exhibited the highest efficacy at 93.79%, followed by Neisseria gonorrhoeae 100C (89.27%), E. coli 200C (79.61%), and Syphilinum 30C (78.76%) against Klebsiella pneumoniae. The average efficacy against Pseudomonas aeruginosa for the 27 test samples studied was 72.32%, (verses Gentamicin 74.25%). The highest efficacy at 92.79% was observed with E. coli poly-nosode followed by methicillin-resistant Staphyloccus aureus (MRSA) 30C (92.29%), N. gonorrhoeae 50C (92.29%), Cantharis 30C (90.95%), and Salmonella typhi 30C poly-nosode (81.35%). Cantharis 30C at 86.53% and E. coli 200C at 78.02% were effective against the mixed infection of E. coli + Candida albicans. The average efficacy of nosodes against this mixed infection was 63.53%, while Gentamicin demonstrated 61.97% efficacy. MRSA 100C showed the highest efficacy at 52.37% against E. coli, and an average efficacy of 44.5% was noted with test samples.

CONCLUSIONS:
Our study unveils the therapeutic potential of homeopathic medicines against antibiotic-resistant bacterial strains.
Exploring the mechanism of sunflower seed oil against Alzheimer’s disease through experimental and network pharmacology studies
Authors: Desai Yashodhan , Karunakaran Deepak , Singh Juhi , Noronha Alric Raul , Poojary Gagan , Chettri Bijaya , Shenoy Rekha , Nampoothiri Madhavan , Bojja Sree Lalitha 
Published: February 2025

Abstract:

OBJECTIVES:
With the prevalence of Alzheimer’s disease (AD) increasing exponentially, there has been a shift in the focus of drug discovery for AD from treating the symptoms to preventing the development of the disease. Several natural compounds are extensively studied as neuroprotectives in preventing disease progression. Helianthus annuus seed oil (HA) is widely used as cooking oil and is abundant in antioxidant activity. Therefore, we evaluated the effect of HA in mice model of scopolamine-induced amnesia and explored the potential underlying mechanisms.

METHODS:
Twenty-four male mice were administered orally with either distilled water (control and scopolamine groups) or treatment groups (HA 100 and HA 200 mg/kg) for 8 consecutive days. All groups, except the control group, received an intraperitoneal injection of scopolamine at a dose of 1 mg/kg. Subsequently, novel object recognition task for cognition assessment and open field tests for locomotory activity were performed. In addition, network analysis was performed to identify the key bioactives and targets of HA against AD. Further, the binding affinity of HA bioactives to the key targets was verified by molecular docking analysis.

RESULTS:
HA (100 mg/kg and 200 mg/kg) significantly ameliorated recognition memory compared to the scopolamine group, suggesting the protective effect of HA against cognitive impairment. Network analysis indicated that the key bioactives of HA, chlorogenic acid, and oleic acid act through multiple targets and pathways, particularly the mitogen-activated protein kinase (MAPK) pathway, to ameliorate AD symptoms. Importantly, chlorogenic acid showed good binding affinity with MAPKs, TP53, and EP300.

CONCLUSION:
HA has therapeutic benefits in AD acting through the MAPK pathway. However, further studies need to be done to confirm the results derived and translate the potential use of HA as a dietary supplement for preventing AD.
The Correlation between Physical Activity, Sedentary Behavior, and Body Mass Index among College Students in Surakarta, Indonesia: A Cross-sectional Study
Authors: Yuniarti Tri , Musta’in  , Adriani Rita Benya , Widiyanto Aris , Atmojo Joko Tri , Putri Santy Irene 
Published: February 2025

Abstract

Introduction:
Young adulthood is a critical developmental period, during which there are key developmental tasks that allow the young adult to participate related to lifestyle behaviors. This research examines the interplay among physical activity (PA), sedentary behavior (SB), and body mass index (BMI) among college students in Surakarta, Indonesia.

Methods:
From January to February 2023, a cross-sectional, online self-administered survey was distributed through WhatsApp and Telegram to prospective respondents aged 17–25 year old. The questionnaire was divided into three sections. The first section of the questionnaire consisted of seven sociodemographic questions about the participants’ age, sex, siblings, parents’ education levels, weight, and height. Eleven questions about respondents’ PA were included in the second section. There were eight questions about participants’ inactive lifestyles in the third section.

Results:
The respondents had an average age of 20.24 ± 0.21 years. Age (β = 0.041; 95% confidence interval [CI] = 0.00–0.08; P = 0.03), PA (β = 0.02; 95% CI = 2.03–2.08; P = 0.02), and SBs on weekdays (β = −1.39; 95% CI = −4.77–1.98; P = 0.01) and weekends (β = −2.23; 95% CI = −9.19 [−1.27]; P = 0.01) were identified as the most significant variables influencing the respondents’ BMI.

Conclusion:
Most college students in Surakarta had a normal weight. Nevertheless, it is noteworthy that nearly all female adolescents fell short of complying with the prescribed physical exercise guidelines, which advocate for a minimum of 420 min of moderate-to-vigorous PA weekly.
Idiopathic portal hypertension misdiagnosed as hepatitis B cirrhosis: A case report and review of the literature
Authors: Liu Xiao-Chen , Yan Hui-Hui , Wei Wei , Du Qin 
Published: February 2025

BACKGROUND
Idiopathic portal hypertension (IPH) is a subtype of portal hypertension that arises in the absence of cirrhosis. IPH frequently manifests with clinical features typical of portal hypertension, including splenomegaly and esophagogastric fundal varices, along with other associated symptoms. Imaging studies may indicate portal hypertension; however, they typically do not provide evidence of cirrhosis. There are no standardized diagnostic criteria for IPH, and diagnosis is often established by excluding other hepatic diseases. Liver biopsy remains the most reliable approach to verify the diagnosis of IPH.
CASE SUMMARY
A patient previously diagnosed with “hepatitis B cirrhosis” at an external hospital presented to our facility with gastrointestinal bleeding. Initial assessment revealed minor liver injury, splenomegaly, esophagogastric varices, and portal hypertension. Imaging studies did not indicate cirrhosis and repeated hepatitis B serology tests yielded negative results. After excluding various causes of cirrhosis and other non-cirrhotic etiologies of portal hypertension, liver biopsy confirmed the diagnosis of IPH. The patient was managed with regular endoscopic therapy and long-term carvedilol administration.
CONCLUSION
Currently, there are no standardized diagnostic criteria for IPH, and its diagnosis is generally established by excluding other conditions. Liver biopsy remains the most reliable method for IPH diagnosis.
ILF3 inhibits p-AMPK expression to drive non-alcoholic fatty liver disease progression
Authors: Zhan Ting , Liu Jia-Xi , Huang Min , Chen Ming-Tao , Tian Xiao-Rong , Yang Xiu-Lin , Tan Jie , Zou Yan-Li , Han Zheng , Chen Wei , Tian Xia , Huang Xiao-Dong 
Published: February 2025

BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is a disease of increasing global prevalence and an important risk factor for the development of insulin resistance, type 2 diabetes, non-alcoholic steatohepatitis and hepatocellular carcinoma, but the pathogenesis is not clear. The aim of this study was to explore the role of ILF3 in NAFLD.
AIM
To investigate the molecular processes through which ILF3 facilitates the advancement of NAFLD by inhibiting the expression of p-AMPK. This exploration seeks to provide new insights into the etiology of NAFLD and evaluate the potential of ILF3 as a diagnostic marker and potential treatment focus for future interventions.
METHODS
In vitro and in vivo experiments were conducted using HepG2 cells and NAFLD animal models. The effects of ILF3 knockdown on lipid synthesis and triglyceride (TG) secretion were examined by analyzing the expression levels of p-AMPK. Additionally, the roles of ILF3 and the AMPK signaling pathway were verified using techniques such as Western blotting, quantitative reverse transcription PCR, Oil Red O staining, and immunohistochemistry.
RESULTS
Investigations revealed an increase in ILF3 Levels within both HepG2 cells and animal models of NAFLD, concurrently with a decrease in p-AMPK expression. Knocking down ILF3 activated the AMPK pathway, reducing lipid production and TG secretion in hepatocytes, thereby mitigating the advancement of NAFLD.
CONCLUSION
ILF3 promotes the evolution of NAFLD by inhibiting the expression of p-AMPK. The knockdown of ILF3 activates the AMPK signaling pathway, alleviating the severity of NAFLD. These findings underscore the function of ILF3 in the pathogenesis of NAFLD and demonstrate its viability as a treatment focus and diagnostic indicator.
Quelle place pour la littérature mondiale dans l’enseignement secondaire français ?
Authors: Lamy-Joswiak Anne-Cécile 
Published: February 2025

La mondialisation de la littérature a remis en question l’enseignement de celle-ci depuis la fin du XXe siècle (Fraisse, 2012 ; Dufays, 2024) et l’enseignement secondaire français n’échappe pas à ce débat, comme en témoigne l’ouverture des programmes nationaux aux littératures étrangères et francophones depuis quatre décennies. L’objectif de cette contribution est de montrer la part accordée à la littérature étrangère dans l’enseignement de la littérature nationale dispensé dans les établissements secondaires français. Pour ce faire, nous avons examiné la représentation de la littérature mondiale dans les instructions officielles et la présence des œuvres étrangères et francophones dans l’offre éditoriale récente des manuels de français. Si l’analyse montre une nette ouverture au patrimoine littéraire mondial, elle questionne aussi bien la hiérarchisation de ses œuvres que les pratiques éducatives pour rendre cet enseignement effectif.
Antidepressant-like Effect of the Leaf Extract of <i>Momordica foetida</i> Schumach. et Thonn. in Rodent Models of Depression
Authors: Yohannes Melekte , Abiye Alfoalem Araba , Hailu Abebe Ejigu , Tadesse Wondmagegn Tamiru 
Published: February 2025

People living with depression develop treatment-resistant depression in which they do not respond to available medications or other therapeutic approaches. Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is used in northern Ethiopia, to treat psychiatric disorders. The current study investigated the antidepressant-like effects of the 80% methanolic leaf extract of M. foetida using the rodent models tail suspension and forced swim tests. The effect of the hydroalcoholic extract on locomotor activity was also studied using the open-field test. Based on the results of acute toxicity test, 100, 200, and 400 mg/kg doses of the extract were tested. In the tail suspension test, the extract as well as the positive control (imipramine 30 mg/kg) showed significant (p < 0.05) reductions in immobility time compared to the control group at all doses. Duration of immobility observed in the forced swim test with the extract was not significantly different from the control group. By contrast, the positive control produced a significant decrease (p < 0.05) in immobility compared to controls. However, no significant change in locomotion was observed in the open field test at these doses. Overall, the results obtained demonstrated that M. foetida extract possesses antidepressant activity in the tail suspension test, providing evidence, at least in part, for the traditional use of the plant for psychiatric disorders. However, further studies are required to validate its use.
Effect of microwave and sodium hypochlorite disinfection of alginate impressions on dimensional accuracy of such impressions
Authors: OMO Julie Omole , ENABULELE Joan Emien , SEDE Matthew  Asizide , IGUNMA Jerry , AKHIGBEMEN Oseremen , ATAT Josephine 
Published: February 2025

Objective: This study investigated the impact of disinfection methods, specifically sodium hypochlorite and microwave irradiation, on the dimensional accuracy of alginate impressions.
Methods: This was a randomized comparative clinical study. A purposive sampling technique of consecutive individuals was employed for the study. The maxillary impression of employed participants was made and randomly assigned to either of two groups (microwave irradiation vs sodium hypochlorite disinfection) by simple random technique. Two impressions were made for each participant. The first impression was poured with dental stone to make a stone cast without disinfection, the second impression made, was disinfected either using 0.5% sodium hypochlorite disinfectant or microwave irradiation for 2 minutes, before a stone cast was made from this impression. The dimensional accuracy of each cast was assessed by measuring the bucco-palatal width of the two maxillary first molars using a handheld digital caliper (with an accuracy of 0.01mm) and getting the average of the two measurements.
Result: A total of 120 upper impressions were made using alginate impression material for 60 participants. The buccolingual dimension of the first molars ranged from 4.32 to 6.10mm before and after sterilization. The mean buccolingual dimension before sterilization was 5.30±0.39 and the mean buccolingual dimension after disinfection was 5.30±0.42, which was not statistically significant (p=0.78). Disinfection with sodium hypochlorite (p=0.94) and microwave irradiation (p=0.74) on the dimensional accuracy of impressions was not statistically significant
Conclusion: There were no significant dimensional inaccuracies in casts obtained from alginate impressions disinfected with sodium hypochlorite or microwave irradiation compared to those obtained from alginate impressions without disinfection
Estratégias utilizadas por cirurgiões-dentistas nas práticas de educação em saúde: avaliação dos acadêmicos de um curso de odontologia
Authors: MIALHE FÁBIO LUIZ , DA SILVA DÉBORA DIAS , DA SILVA RENATO PEREIRA , GONÇALO CAMILA DA SILVA , DE SOUZA HELOISA WESSEL 
Published: February 2025

O objetivo deste estudo foi avaliar os relatos de acadêmicosdo curso de Odontologia da Unioeste sobre estratégias de educação emsaúde bucal desenvolvidas pelos cirurgiões-dentistas que os mesmosfreqüentavam. A coleta de dados foi realizada através de um questionáriocom perguntas fechadas. As questões foram relativas a informaçõesrecebidas através do cirurgião dentista sobre como cuidar da saúde bucal,técnicas de higiene bucal, controle de placa e como foi o processo deensino. Dos 210 acadêmicos matriculados, 173 (86,1%) devolveram osquestionários devidamente preenchidos. Destes, apenas 12,2% afirmouter sido o cirurgião dentista responsável pela primeira informação decomo cuidar da saúde bucal. Quanto à técnica de higiene bucal, mais dametade (54,3%) relatou que o profissional ensinou como escovar osdentes, mas nem a metade dos acadêmicos (49,7%) aprendeu com o dentista como usar o fio dental. Com relação ao processo de ensino docontrole de placa, o método mais citado foi o verbal (27,2%). Diantedestes resultados fica claro que o papel do cirurgião dentista, que deveriaser o de promotor de saúde, com ênfase para a educação em saúde bucal,ainda encontra-se deficiente, evidenciando que a Odontologia precisavalorizar a promoção de saúde para que esta realidade seja revertida.