bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding super engaged users in the 10,000 Steps online physical activity program: A qualitative study
Authors: Vandelanotte Corneel , Hooker Cindy , Van Itallie Anetta , Urooj Anum , Duncan Mitch J. 
Published: October 2022

Objective
Sustained engagement with Internet-based behavioural interventions is crucial to achieve successful behaviour change outcomes. As this has been problematic in many interventions, a lot of research has focused on participants with little or no engagement. However, few studies have attempted to understand users with continuous long-term engagement, the so called ‘super engaged users’, and why they keep on using programs when everybody else has long stopped. Therefore, the aim of this research was to qualitatively examine characteristics, usage profile and motivations of super engaged users in the 10,000 Steps program.

Methods
Twenty 10,000 Steps users (10 with more than 1 year of engagement, and 10 with more than 10 years of engagement) participated in semi-structured interviews, that were transcribed and thematically analysed.

Results
Participants were aged 60 years on average, with more than half being overweight/obese and/or suffering from chronic disease despite logging high step counts (219 million steps per participant on average) on the 10,000 Steps platform. Participants indicated that the reasons for sustained use were that engaging the program had become a habit, that the program kept them motivated, and that it was easy to use. Few participants had suggestions for improvement or expressed there were program elements they did not like. Uptake of program innovations (e.g., app-version, use of advanced activity tracker instead of pedometer) was modest among the super engaged users.

Conclusion
The findings from this study emphasise the need for digital health programs to incorporate features that will support the development of habits as soon as participants start to engage with the program. While a program’s usability, user-friendliness and acceptability are important to engage and retain new users, habit formation may be more important for sustained long-term engagement with the behaviour and the program.
Comparison of three short-course rifamycin-based regimens for the prevention of tuberculosis in patients with end-stage kidney disease: Study protocol for a randomised clinical trial (RIFAKiD-TB trial)
Authors: Santin Miguel , Perez-Recio Sandra , Grijota Maria D. , Anibarro Luis , Barcala Jose M. , De Souza-Galvao Maria L. , Gijon Paloma , Luque Rafael , Sanchez Francesca ,   on behalf of the RIFAKiD team trial
Published: October 2022

Background and purposeScreening for and treatment of latent tuberculosis (TB) in patients with end-stage kidney disease (ESKD) are recommended. However, there is limited evidence on safety and treatment completion in this population. The objective of the study is to evaluate three short-course rifamycin-based regimens for the treatment of latent TB in ESKD patients.MethodsStudy design and setting. This is a prospective, open label, randomized clinical trial, that will be conducted at seven teaching hospitals in Spain.Study population, randomization, and interventions. Consecutive adult patients with ESKD requiring treatment for a latent TB infection will be randomly allocated (1:1:1) to receive one of the three treatment regimens of the study: three months of daily isoniazid plus rifampicin (3HR); three months of once-weekly isoniazid plus rifapentine (3HP); or four months of daily rifampicin (4R). Participants will be followed regularly through pre-established visits and a blood test schedule from enrolment to a month after finishing the assigned treatment.Outcomes. The primary outcome will be treatment completion, while the secondary outcomes will be discontinuation of the assigned treatment due to adverse events, related or unrelated to the study treatment; definitive discontinuation of the assigned treatment because of adverse events related to the treatment of the study, and death.Sample size. Two hundred and twenty-five subjects (75 per arm) will be enrolled, which will enable the demonstration, if it exists, of an increase of 0.16 in treatment completion rates either in the 3HP or 4R arm with respect to the 3HR arm.DiscussionResults of this clinical trial will contribute to evidence-based recommendations on the management of latent TB infection in ESKD patients.Trial registrationClinicalTrials.gov identifier:NCT05021731.
PentaRay® Multielectrode Mapping Catheter for Atrial Tachyarrhythmia in Adults With Congenital Heart Disease
Authors: Dodeja Anudeep K. , Tan Yubo , Ackley Tamara , Russell Jennifer , Kertesz Naomi , Daniels Curt J. , Kamp Anna 
Published: October 2022

Background
Ablation of atrial tachyarrhythmia in adults with congenital heart disease (ACHD) is challenging because of complex anatomy and high scar burden. We proposed that the addition of high-density mapping with the PentaRay® (Biosense Webster, Inc) mapping catheter (EAM+P) to 3-dimensional electroanatomic mapping (EAM) allows for rapid acquisition of high-resolution maps and shorter procedure times.

Methods
In this single-center, retrospective cohort study of patients with ACHD who underwent atrial arrhythmia ablation, patients were divided those who underwent ablation with EAM and those who underwent ablation with EAM+P.

Results
Fifteen ablations were performed in 13 patients using standard EAM, and 11 ablations were performed in 10 patients using EAM+P. There was no difference in mean age or complexity of congenital heart disease. The procedure duration was 1.5 times longer in the EAM than in the EAM+P group (P = .015). The dose area product was 12 times higher in the EAM than in the EAM+P group (P = .001). A higher number of venous access sites were used for EAM cases than for EAM+P cases (P = .008). Acute success rates of ablation and recurrence rates at 1 year were similar in the 2 groups. There were no procedure-related complications in either group.

Conclusion
This is the first study to evaluate the use of the PentaRay® high-density mapping catheter for ablation of atrial tachyarrhythmia in patients with ACHD. The use of the PentaRay® high-density mapping catheter results in shorter procedure time, decreased radiation exposure, and fewer venous access sites.
Pengaruh Harga Dan Experiential Marketing Terhadap Loyalitas Pelanggan Melalui Kepuasan Konsumen Sebagai Variabel Intervening Pada Konsumen General Repair PT Nasmoco Pemuda Semarang
Authors: Dilla Sri Farah , Ngatno Ngatno 
Published: October 2022

Abstract: Total of customers General Repair Service of PT Nasmoco Pemuda Semarang has fluctuated due to customer commitment changes. This study aims to determine the effect of price and experiential marketing on customer loyalty through customer satisfaction as an intervening variable in the General Repair Service of PT Nasmoco Pemuda Semarang. This research is explanatory research with an accidental sampling method before the pandemic and purposive sampling after the pandemic. It used interviews and questionnaires as a data collection technique to 100 respondents, whoever uses General Repair service at PT Nasmoco Pemuda Semarang City. The data covered area on Central Semarang, North Semarang, East Semarang , South Semarang, Gajahmungkur, and Candisari. This sub-districts are the largest contributor to the General Repair Service of PT Nasmoco Pemuda Semarang customers. This research used the SPSS 21.0 application and Sobel analysis. The Sobel test results state that customer satisfaction is able to partially mediate between price and experiential marketing on customer loyalty. The correlation coefficient of price and experiential marketing variables to customer satisfaction has a strong relationship. Company should offering some discounts to be more engaging. Other than that, to not neglect the quality of the facilities that already served at PT Nasmoco Pemuda Semarang General Repair, for example, WiFi.Keywords: Price; Experiential Marketing; Customer Satisfaction; Customer Loyalty Abstrak: Jumlah pelanggan Layanan General Repair PT Nasmoco Pemuda mengalami fluktuatif yang disebabkan adanya perubahan komitmen pelanggan. Penelitian ini bertujuan untuk mengetahui pengaruh harga dan experiential marketing terhadap loyalitas pelanggan melalui kepuasan konsumen sebagai variabel intervening pada Layanan General Repair PT Nasmoco Pemuda Semarang. Tipe penelitian ini adalah explanatory research dengan metode accidental sampling sebelum pandemi dan purposive sampling setelah pandemi. Teknik pengumpulan data menggunakan wawancara dan kuesioner kepada 100 responden yang pernah melakukan service pada layanan General Repair PT Nasmoco Pemuda Kota Semarang yang berdomisili Kecamatan Semarang Tengah, Semarang Utara, Semarang Timur, Semarang Selatan, Gajahmungkur dan Candisari. Teknik analisis data menggunakan aplikasi SPSS 21.0 serta analisis sobel. Hasil uji Sobel menyatakan bahwa kepuasan konsumen mampu memediasi parsial antara harga dan experiential marketing terhadap loyalitas pelanggan. Koefisiensi korelasi harga dan experiential marketing terhadap kepuasan konsumen memiliki hubungan yang kuat. Perusahaan hendaknya meningkatkan potongan harga yang lebih menarik dan lebih memperhatikan fasilitas yang ada pada layanan General Repair PT Nasmoco Pemuda Semarang seperti WiFi.Kata Kunci: Harga; Experiential Marketing, Kepuasan Konsumen; Loyalitas Konsumen
Pengaruh E-Wom Terhadap Repurchase Intention Melalui E-Trust Sebagai Mediasi Pada Konsumen Tiket Kereta Di Kai Access (Studi Pelanggan Kereta Argo Sindoro Jurusan Semarang-Jakarta Pada Kai Access Kota Semarang)
Authors: Putri Erika Aulia , Pradhanawati Ari 
Published: October 2022

Abstract: One type of transportation that fits these criteria is the Indonesian Railroad. PT KAI itself has various types of train levels, such as economy class, business class, and executive class. The purpose of this study was to determine the effect of e-WOM on repurchase intention through e-trust as a mediation for train ticket consumers through KAI Access. The data collection technique used a questionnaire that was distributed to 100 KAI Access consumer respondents in Semarang. The analysis technique of this research is using the SPSS version 16.0 program. The results show that e-WOM has a positive and significant effect on repurchase intention, e-trust has a positive and significant effect on repurchase intention, e-WOM has a positive and significant effect on e-trust, e-WOM has a positive and significant effect on repurchase intention through e-trust mediation. Based on the research results, it is suggested that KAI Access can improve the features of the application system to make it easier for consumers to get information, expand e-money partners so that consumers make payments easier, and improve the quality of the security system on KAI Access to minimize consumer concerns in the event of a server disturbance. Keywords: e-WOM; e-trust; Repurchase Intention Abstrak: Salah satu jenis transportasi yang cocok untuk kriteria tersebut adalah Kereta Api Indonesia. PT.KAI sendiri memiliki berbagai jenis tingkatan kereta, seperti kelas ekonomi, kelas bisnis, dan kelas eksekutif. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh e-WOM terhadap repurchase intention melalui e-trust sebagai mediasi pada konsumen tiket kereta api melalui KAI Access. Teknik pengumpulan data menggunakan kuesioner yang dibagikan kepada 100 responden konsumen KAI Access di Semarang. Teknik analisis penelitian ini menggunakan program SPSS versi 16.0. Hasil penelitian menunjukkan bahwa e-WOM berpengaruh positif dan signifikan terhadap repurchase intention, , e-trust berpengaruh positif dan signifikan terhadap repurchase intention, e-WOM berpengaruh positif dan signifikan terhadap e-trust, e-WOM berpengaruh positif dan signifikan terhadap repurchase intention melalui mediasi e-trust. Berdasarkan hasil penelitian maka disarankan supaya KAI Access dapat meningkatkan fitur pada sistem aplikasi untuk memudahkan konsumen mendapatkan informasi, memperluas mitra e-money agar konsumen lebih mudah melakukan pembayaran, dan meningkatkan kualitas sistem keamanan pada KAI Access meminimalisir kekhawatiran konsumen jika terjadi gangguan server.Kata kunci: e-WOM; e-trust; Repurchase Intention
Die „wilden Siebziger“ und ihre „gegnerischen Soziologien“.
Authors: Moebius Stephan , Römer Oliver 
Published: October 2022

ZusammenfassungGegenstand des Beitrages ist die historische Konstellation der westdeutschen Soziologie der 1970er Jahre. Während die Anfänge der bundesrepublikanischen Soziologie ein inzwischen gut untersuchtes Feld sind, bleiben die fachlichen Entwicklungen und Besonderheiten dieser Dekade bisher stark unterbeleuchtet. In den 1960er Jahren als gesellschaftliche Orientierungs- und Reformdisziplin entdeckt, wurde die Soziologie in den Siebzigern zum Ort eines vielschichtigen Kulturkampfes, der unterschiedliche Hoffnungen, Befürchtungen und Parteilichkeiten aufeinander bezog. Mit der gesteigerten gesellschaftlichen Wahrnehmung und Einbeziehung soziologischen Wissens und Denkens in den gesellschaftlichen Diskurs gingen unterschiedlichste Formen der Polarisierung einher. Inwiefern bietet die soziologische Konstellation der siebziger Jahre einen alternativen Modellfall für die Konstitutionalisierung der Sozialwissenschaften, der weder von wissenschaftslogisch begründeten Konzepten einer Einheitswissenschaft noch von Parteinahmen für eine soziologische Theorien- und Methodenpluralität gedeckt ist?
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication
Authors: Pouikli Andromachi , Maleszewska Monika , Parekh Swati , Yang Ming , Nikopoulou Chrysa , Bonfiglio Juan Jose , Mylonas Constantine , Sandoval Tonantzi , Schumacher Anna‐Lena , Hinze Yvonne , Matic Ivan , Frezza Christian , Tessarz Peter 
Published: October 2022

AbstractBone‐derived mesenchymal stem cells (MSCs) reside in a hypoxic niche that maintains their differentiation potential. While hypoxia (low oxygen concentration) was reported to critically support stem cell function and osteogenesis, the molecular events triggering changes in stem cell fate decisions in response to normoxia (high oxygen concentration) remain elusive. Here, we study the impact of normoxia on mitochondrial–nuclear communication during stem cell differentiation. We show that normoxia‐cultured murine MSCs undergo profound transcriptional alterations which cause irreversible osteogenesis defects. Mechanistically, high oxygen promotes chromatin compaction and histone hypo‐acetylation, particularly on promoters and enhancers of osteogenic genes. Although normoxia induces metabolic rewiring resulting in elevated acetyl‐CoA levels, histone hypo‐acetylation occurs due to the trapping of acetyl‐CoA inside mitochondria owing to decreased citrate carrier (CiC) activity. Restoring the cytosolic acetyl‐CoA pool remodels the chromatin landscape and rescues the osteogenic defects. Collectively, our results demonstrate that the metabolism–chromatin–osteogenesis axis is perturbed upon exposure to high oxygen levels and identifies CiC as a novel, oxygen‐sensitive regulator of the MSC function.
Multi-Event Explosive Seismic Source for the 2022 Mw 6.3 Hunga Tonga Submarine Volcanic Eruption
Authors: Thurin Julien , Tape Carl , Modrak Ryan 
Published: October 2022

Abstract
The eruption of the Hunga Tonga–Hunga Ha’apai submarine volcano on 15 January 2022 produced a variety of geophysical responses, including a significant seismic signal. We study the seismic source process of this event by inverting for moment tensors (MTs) using regional surface waves (Rayleigh, Love). By comparing inversion results for the eruption with eight nearby earthquakes, we show that it is possible to discriminate MT source types. Our inversion yields a shallow explosive source for the eruption and reveals the importance of trade-offs among depth, magnitude, and source type. We illustrate these trade-offs by representing the misfit variations over the eigenvalue lune. Finally, we invert for the source-time function of the sequence of explosions that occurred in the first minutes of the eruption. The multi-event source-time function comprises four subevents spanning ∼270 s, with a total magnitude estimate of Mw 6.34 ± 0.10.
Knowledge and Attitudes of Dengue Virus Infection Transmission and Its Relationship with Eradication Action Program in Surabaya, Indonesia
Authors: Juliasih Ni Njoman , Sucipto Teguh Hari , Sari Reny Mareta , Nuha Zakiyathun , Soegijanto Soegeng 
Published: October 2022

Dengue virus infection is caused by a dengue virus transmitted through mosquito bites from species Aedes albopictus and Aedes aegypti. The Ministry of Health takes action to reduce the prevalence of DHF by regulating the management of PSN 3M Plus. This study aimed to determine the knowledge, attitude, and compliance with the management of PSN 3M Plus strategies of those living in Surabaya. A cross-sectional population-based google form questionnaire was conducted in January 2022 for four weeks (January 3, 2022, to January 29, 2022). Based on the bivariate analysis, gender and age of respondents were no relationship between compliance with the PSN 3M Plus (p-value >0.05). The results also showed no relationship between education and adherence to PSN 3M Plus (p-value > 0.05). However, based on previous studies, people with higher education showed better compliance. Public knowledge and attitude about the dengue virus and its transmission process can be increased by developing, modifying, and intervening in the people controlling dengue virus infection. Most people of Surabaya believe that dengue prevention is the complete responsibility of every people. Based on the bivariate analysis, the characteristics of respondents had no relationship with the PSN 3M Plus compliance (p-value > 0.05). Knowledge and attitudes of the Surabaya people toward PSN 3M Plus are still good. However, the characteristics of the respondents did not significantly affect their knowledge and attitudes
Encryption Based Simple and Robust Subscriber – Client Authentication Protocol for Ultralightweight Sensor Networks
Authors: Chakraborty Rajdeep , Acharya Aheli , Paul Debasmita , Guha Debajyoti , Elngar Ahmed A. 
Published: October 2022

Abstract
Safety is the most important part of IoT networks. A maximum number of IoT devices are resource constrained, it is difficult to implement strong safety mechanisms. The maximum number of authentication techniques use certificates in which signing and verifying require additional computation and power. Thus, the goal of this paper is to propose a new lightweight encryption-based authentication protocol for resource-controlled devices. In this paper we proposed an authentication protocol that uses RRSC – v1 encryption and one subscriber and several clients. The main objective is to develop an ultralightweight protocol for a very low-resourced sensor network. In this protocol, we have two algorithms, first, one to one encryption-based authentication protocol where the client is the low resource sensor and the subscriber is the edge device in the IoT. Second, the RRSC – V1, encryption algorithm itself. It has many applications for temperature sensors, rain sensors, and smoke sensors as they have very low memories and computing capacity.
Development of a MOF-based SPE method combined with GC-MS for simultaneous determination of alachlor, acetochlor and pretilachlor in field soil
Authors: Cai Yjuan , Li Liying , Zhang Jun , Li Zhenjie , Zhang Fengmei , Xu Yanqun , Tai Zhigang 
Published: October 2022

Abstract
In this work, a rapid, highly selective, reusable and effective method was developed for simultaneous determination of alachlor, acetochlor and pretilachlor in field soil by GC-MS coupled with MIL-101 based SPE. Main factors affecting the SPE by using MIL-101 were optimized. Moreover, by comparing with the other commercial materials such as C18, PSA and Florisil, the MIL-101(Cr) exhibited excellent adsorption performance, which aimed at amide herbicides. On the other hand, method validation displayed excellent method performance, achieving good linearities with r2 ≥ 0.9921, limits of detection between 0.25–0.45 µg kg− 1, enrichment factors ≥ 89, matrix effect in the range of ± 20%, recoveries between 86.3% and 102.4%, and RSD lower than 4.38%. The developed method was successfully applied to the determination of amide herbicides in soil taken from the wheat, corn and soybean field at different depths, where the concentration of alachlor, acetochlor and pretilachlor were in the range of 0.62–8.04 µg kg− 1. It was demonstrated that the more depth of soil, the lower of three amide herbicides. This finding could be proposed a novel method to detect the amide herbicides in the agriculture and food industry.
Higher TOX（Thymocyte selection-associated high mobility group box）expression in tumor microenvironment predicts poor prognosis in patients with ovarian cancer
Authors: Li Sai , Yang Sifu , Hong Yupeng 
Published: October 2022

AbstractBackground:Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identifying some biomarkers for early diagnosis, prediction of prognosis and disease monitoring. TOX, a critical transcription factor related to the development of malignancies that contributing to lymphocytes not just T cells, had been proved prognostic value in some spectrum of cancers. Here, we aimed to study the prognostic role of TOX in ovarian cancer.Results:We found that TOX was not only expressed in CD8 T cells but also tumor cells. TOX expression score was higher in ovarian cancer tissues and correlated with survival status. Survival analysis revealed that ovarian cancer patients with high TOX expression score generally shorter overall survival and disease-free survival times. Univariate and Multivariate Cox demonstrated that TOX expression score could be used as an independent prognostic factor for patients with ovarian cancer.Conclusion:TOX expression in ovarian cancer could be a promising tool for predict overall survival of ovarian cancer patients.