bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis
Authors: Aleid Abdulsalam Mohammed , Alshehri Faisal , Alasiri Naif , Alhomoud Fatimah , Alsaegh Shouq , Alrasheed Mohammed , Aljaddua Salem , Alasiri Ali , Boukhari Asma , Alhussain Abdulmonem Ali , Chaurasia Bipin , Aldanyowi Saud Nayef 
Published: January 2025

ABSTRACTBackgroundDuloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain. We conducted this systematic review and meta‐analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain.MethodsWe searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024. The following search terms were Used in combination using the Boolean operators ((Duloxetine Hydrochloride) AND ((Pain, Postoperative) OR (Postoperative Period) OR (Postoperative Cognitive Complications) OR (Delayed Emergence from Anesthesia) OR (Postoperative Care) OR (spine surgery)) without time constrain for the search. Meta‐analysis was performed using Review Manager (RevMan version 5.4) on the extracted outcome data that present in at least 3 of the included studies. Mean difference (MD) was used as the effect size for continuous outcomes with a 95% confidence interval (CI) or standardized mean difference (SMD) in case of different outcome reporting scales.ResultsPooled analysis showed that duloxetine significantly reduces pain intensity after 24 h from the operation compared to placebo (SMD = −1.11, 95% CI [−2.16 to −0.07], p = 0.04) with no significant difference in pain after 2 and 48 h. Meta‐analysis revealed that duloxetine shows a significant reduction in the amount of analgesic consumption after 24 h postoperative; (MD = −3.33, 95% CI [−5.53 to −1.13], p = 0.003). The analysis did not show any statistically significant difference between duloxetine and placebo in patients experiencing nausea or vomiting (RR = 1.37, 95% CI [0.62 to 3.00]ConclusionThe findings of this study suggest that duloxetine may be effective in reducing pain 24 h after spine surgery. Furthermore, there is a promising effect of duloxetine in treating chronic postoperative pain. However, it is important to acknowledge that further research is warranted to thoroughly evaluate the efficacy and safety of duloxetine for relieving chronic postoperative pain.
A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice
Authors: Liu Xi , Zhang Xi , Wang Dongxu , Cao Ya , Zhang Ling , Li Zhonghua , Zhang Qin , Shen Yu , Lu Xian , Fan Keyu , Liu Mingxia , Wei Jingqiu , Hu Siping , Liu He 
Published: January 2025

ABSTRACTBackgroundPain is a prevalent comorbidity in numerous clinical conditions and causes suffering; however, the mechanism of pain is intricate, and the neural circuitry underlying pain in the brain remains incompletely elucidated. More research into the perception and modulation of pain within the central nervous system is essential. The nucleus accumbens (NAc) plays a pivotal role in the regulation of animal behavior, and extensive research has unequivocally demonstrated its significant involvement in the occurrence and development of pain. NAc receives projections from various other neural nuclei within the brain, including the paraventricular nucleus of the thalamus (PVT). In this experiment, we demonstrate that the specific glutamatergic neural circuit projection from PVT to NAc (PVTGlut→NAc) is implicated in the modulation of inflammatory pain in mice.MethodsWe compared the difference in pain thresholds between complete Freund's adjuvant (CFA)‐induced inflammatory pain models and controls. Then in a well‐established mouse model of CFA‐induced inflammatory pain, immunofluorescence staining was utilized to evaluate changes in c‐Fos protein expression within PVT neurons. To investigate the role of PVTGlut→NAc in the modulation of pain, we used optogenetics to modulate this neural circuit, and nociceptive behavioral tests were employed to investigate the functional role of the PVTGlut→NAc circuit in the modulation of inflammatory pain.ResultsIn the mice with the inflammatory pain group, both the paw withdrawal latencies (PWLs) and paw withdrawal thresholds (PWTs) of the right hind paw were decreased compared to the control group. In addition, compared to the control group, CFA‐induced inflammatory pain led to increased c‐Fos protein expression in PVT, which means that some of the neurons in this area of the brain region have been activated. Following the injection of retrograde transport fluorescent‐labeled virus into NAc, glutamatergic neurons projecting from the PVT to NAc were observed, confirming the projection relationship between PVT and NAc. In the experiments in optogenetic regulation, normal mice exhibited pain behavior when the PVTGlut→NAc circuit was stimulated by a 473 nm blue laser, resulting in decreased PWLs and PWTs compared to the control group, which means activating this neural circuit can lead to painful behaviors. In the CFA‐induced pain group, inhibition of the PVTGlut→NAc circuit by a 589 nm yellow laser alleviated pain behavior, leading to increased PWLs and PWTs compared to the control group, representing the fact that inhibition of this neural circuit relieves pain behaviors.ConclusionsThe findings unveil a pivotal role of the PVTGlut→NAc circuit in modulating inflammatory pain induced by CFA in mice.
The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post‐Traumatic Stress Disorder
Authors: Hinostroza Fernando , Mahr Michele M. 
Published: January 2025

ABSTRACTIntroductionThis extensive literature review investigates the relationship between post‐traumatic stress disorder (PTSD) and alcohol use disorder (AUD), focusing on the neurobiological changes associated with their co‐occurrence. Given that these disorders frequently coexist, we analyze mechanisms through which alcohol serves as a coping strategy for PTSD symptoms, particularly highlighting the drinking‐to‐cope self‐medication model, which suggests that alcohol use exacerbates PTSD symptoms and complicates recovery.MethodsA systematic literature search was conducted across multiple databases, including PubMed and Google Scholar, to identify studies examining the intersection of the biopsychosocial model with PTSD, AUD, and associated neural alterations.ResultsFindings demonstrate that chronic PTSD is associated with progressive dysfunction in the amygdala, hippocampus, prefrontal cortex, hypothalamic–pituitary–adrenal axis, and white matter pathways. Also, our findings underscore alterations within the reward system, prefrontal cortex, hippocampus, amygdala, basal ganglia, and hypothalamic–pituitary–adrenal axis that contribute to the pathophysiology of AUD. Our results support the notion that a biopsychosocial framework is essential for contemporary addiction treatment, particularly in the context of alcohol addiction and PTSD.ConclusionPTSD frequently leads individuals to use alcohol as a maladaptive coping strategy, ultimately resulting in neuroadaptive alterations across critical brain regions. These neurobiological changes contribute to the development and maintenance of AUD. The findings reiterate the necessity of employing a biopsychosocial model in treating individuals grappling with both PTSD and AUD. This model allows for a comprehensive understanding of the unique challenges faced by this population, integrating biological, psychological, and social factors that influence recovery.
Suicide in Bangladesh: An Ecological Systems Analysis
Authors: Arafat S. M. Yasir , Saleem Tamkeen 
Published: January 2025

ABSTRACTBackgroundSuicide happens due to a complex interaction among multiple factors. Hence, prevention strategies should consider a wider range of personal and ecological aspects. It is an underprioritized public health problem in Bangladesh where risk factors for suicide have been poorly studied, and there is no national suicide prevention strategy. Therefore, exploring socioecological aspects of suicidal behavior would foster suicide prevention in the country.ObjectivesWe aim to discuss the ecological model for suicide and suicide prevention in Bangladesh.MethodsWe performed a narrative review and organized the risk factors and prevention strategies according to the socioecological model in the context of Bangladesh. We used ecological systems to analyze risk factors for suicide and suicide prevention strategies in the country.ResultsBased on the available evidence, we categorized the risk factors for suicide into ontogenic system, microsystem, mesosystem, exosystem, macrosystem, and chronosystem. In addition, we contextualized the existing suicide prevention initiatives and potential suicide prevention strategies in ontogenic system, microsystem, mesosystem, exosystem, macrosystem, and chronosystem.ConclusionsThis article explored suicide and suicide prevention in Bangladesh through the lens of ecological systems theory that may foster the formulation of a national suicide prevention strategy in the country.
Elevated Serum Homocysteine Levels Impair Embryonic Neurodevelopment by Dysregulating the Heat Shock Proteins
Authors: Mai Jia , Yang Ling , Wang Min , Deng Jia‐Min , Min Min , Xie Hong‐Jian , Jiang Yong‐Mei , Sun Hua‐Qin , Liu Xiao‐Juan 
Published: January 2025

ABSTRACTObservational studies have found that elevated serum homocysteine (Hcy) levels during pregnancy may be associated with the occurrence of neural tube defects (NTDs). However, the effect of Hcy on fetal neural development and its underlying molecular mechanisms remains unclear. To uncover the molecular mechanism, we analyzed the serum Hcy concentration in pregnant women with normal and abnormal pregnancy outcomes and treated zebrafish model embryos with high Hcy. Our findings indicate that elevated serum Hcy levels during pregnancy are associated with adverse pregnancy outcomes. Using the zebrafish model and transcriptome analysis, we found that high Hcy levels led to developmental neural malformations in embryos and affected the expression of key genes at various stages of neural development. Interestingly, deep transcriptome analysis showed that dysregulated heat shock proteins (HSP) might play a key role in high Hcy‐mediated alterations in neural development. Importantly, the inhibition of HSP significantly restored the embryonic neuroteratogenic effects induced by high Hcy levels in the zebrafish model. In summary, our findings provide a novel molecular pathogenic mechanism in which ectopic HSP is associated with neural development defects caused by high Hcy levels, suggesting potential prevention and targeted therapies for high Hcy level‐related NTDs during pregnancy.
Diastereoselective Entry to Novel Aminoindolizidines with Fused Furan, Thiophene, and Pyrrole Ring Starting from L‐Glutamic Acid
Authors: Fraňová Paula , Šafář Peter , Moncoľ Ján , Žídeková Ivana , Daïch Adam , Marchalín Štefan 
Published: January 2025

AbstractA series of novel optically pure aminoindolizidines featuring fused tetrahydro‐furan, thiophene, or pyrrole ring were synthesized from the proteinogenic L‐glutamic acid as a chiral precursor and a nitrogen atom source. The synthetic sequence employed tricyclic indolizidinols as advanced building blocks, which were prepared on a gram‐scale from bioavailable reagents. Key transformations within the used synthetic sequence included diastereoselective Thompson azidation, Staudinger reduction, Jurjew reaction, and highly diastereoselective catalytic hydrogenation. These steps facilitated the efficient and stereoselective synthesis of the ultimate amino‐ and N‐acetylamino‐indolizidines.
持続頭蓋内圧測定が有用であった中等症穿通性脳損傷の1例(Successful management of penetrating moderate traumatic brain injury using intracranial pressure monitoring: A case report)
Authors: 聡汰 若原 , 良 山元 , 一希 松村 , 崇行 渋沢 , 智宏 栗原 , 淳 並木 , 淳一 佐々木 
Published: January 2025

要旨　30歳代の男性。他害のナイフによる頭部・胸部の多発刺創で搬送された。来院時Glasgow Coma Scale（GCS）13（E3V4M6）で瞳孔不同があり，頭部CTで鼻根部から右前頭葉に達する穿通性脳損傷を認めた。受傷後3時間でGCS 10（E2V3M5）へ低下し，頭部CTにて脳室内血腫による水頭症を認めた。脳室ドレナージを行い，脳実質にintracranial pressure（ICP）モニターを留置した。術後は浸透圧利尿薬の投与などによるICPの制御を行ったが，第4病日に治療抵抗性のICP上昇を認めた。画像検査ではICP上昇の原因は明らかではなく，脳波検査が実施できなかったが非痙攣性てんかん重積（non–convulsive status epilepticus: NCSE）なども鑑別に挙げ，てんかん重積治療効果を含めICP降下作用を期待してバルビツレートを開始し，ICPは正常化した。その後は意識レベルは改善し，リハビリ病院へ転院，6か月後の転帰はGlasgow Outcome Scale moderate disabilityであった。穿通性脳損傷では，外傷性てんかんなどの合併症が多いため，GCS 9–13の中等症外傷性脳損傷であっても，ICPモニタリングを含めた神経集中治療を積極的に開始し，難治性のICP上昇に対してはバルビツレート療法なども考慮すべきと考えられる。
Primary sclerosing cholangitis in children with inflammatory bowel disease: An ESPGHAN position paper from the Hepatology Committee and the IBD Porto group
Authors: van Rheenen Patrick F. , Kolho Kaija‐Leena , Russell Richard K. , Aloi Marina , Deganello Annamaria , Hussey Séamus , Junge Norman , De Laffolie Jan , Deneau Mark R. , Fitzpatrick Emer , Griffiths Anne M. , Hojsak Iva , Nicastro Emanuele , Nita Andreia , Pakarinen Mikko , Ricciuto Amanda , de Ridder Lissy , Sonzogni Aurelio , Tenca Andrea , Samyn Marianne , Indolfi Giuseppe 
Published: January 2025

AbstractObjectiveWe aimed to provide an evidence‐supported approach to diagnose, monitor, and treat children with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC).MethodsThe core group formulated seven PICO‐structured clinical questions. A systematic literature search from inception to December 2022 was conducted by a medical librarian using MEDLINE and EMBASE. Core messages from the literature were phrased as position statements and then circulated to a sounding board composed of international experts in pediatric gastroenterology and hepatology, histopathology, adult gastroenterology and hepatology, radiology, and surgery. Statements reaching at least 80% agreement were considered as final. The other statements were refined and then subjected to a second online vote or rejection.ResultsRegular screening for gamma‐glutamyltransferase (GGT) is essential for detecting possible biliary disease in children with IBD. MR cholangiopancreatography is the radiological modality of choice for establishing the diagnosis of PSC. Liver biopsy is relevant in the evaluation of small duct PSC or autoimmune hepatitis. Children who do not have known IBD at the time of PSC diagnosis should undergo initial screening with fecal calprotectin for asymptomatic colitis, and then at least once yearly thereafter. Children with a cholestatic liver enzyme profile can be considered for treatment with ursodeoxycholic acid and can continue if there is a meaningful reduction or normalization in GGT. Oral vancomycin may have a beneficial effect on GGT and intestinal inflammation, but judicious use is recommended due to the lack of long‐term studies. Children with PSC–IBD combined with convincing features of autoimmune hepatitis may benefit from corticosteroids and antimetabolites.ConclusionsWe present state‐of‐the‐art guidance on the diagnostic criteria, follow‐up strategies, and therapeutic strategies and point out research gaps in children and adolescents with PSC–IBD.
A Comparative Study between Thiol‐Ene and Acrylate Photocrosslinkable Hyaluronic Acid Hydrogel Inks for Digital Light Processing
Authors: Steudter Therese , Lam Tobias , Pirmahboub Hamidreza , Stoppel Christian , Kloke Lutz , Pearson Samuel , del Campo Aránzazu 
Published: January 2025

AbstractPhotocrosslinkable formulations based on the radical thiol‐ene reaction are considered better alternatives than methacrylated counterparts for light‐based fabrication processes. This study quantifies differences between thiol‐ene and methacrylated crosslinked hydrogels in terms of precursors stability, the control of the crosslinking process, and the resolution of printed features particularized for hyaluronic acid (HA) inks at concentrations relevant for bioprinting. First, the synthesis of HA functionalized with norbornene, allyl ether, or methacrylate groups with the same molecular weight and comparable degrees of functionalization is presented. The thiol‐ene hydrogel precursors show storage stability over 15 months, 3.8 times higher than the methacrylated derivative. Photorheology experiments demonstrate up to 4.7‐times faster photocrosslinking. Network formation in photoinitiated thiol‐ene HA crosslinking allows higher temporal control than in methacrylated HA, which shows long post‐illumination hardening. Using digital light processing, 4% w/v HA hydrogels crosslinked with a dithiol allowed printing of 13.5 × 4 × 1 mm3 layers with holes of 100 µm resolution within 2 s. This is the smallest feature size demonstrated in DLP printing with HA‐based thiol‐ene hydrogels. The results are important to estimate the extent to which the synthetic effort of introducing –ene functions can pay off in the printing step.
Summary of Recommendations for the Future
Authors: Montagna Paul A. , Douglas Audrey R. 
Published: January 2025

AbstractWhile freshwater inflow (FWI) needs for the maintenance of estuary health have long been acknowledged, environmental flow standards or, specifically, FWI standards are still uncommon. Where they exist, they are rapidly evolving over time. Texas, USA, has been working on this problem since the 1960s. Through several iterations, the legal and regulatory framework evolved from a species management approach to an ecosystem-based management one. More recently, based on extensive scientific research, Texas adopted FWI standards for all the major bay systems between 2011 and 2014. After a decade however, new technical questions and problems have arisen. There are at least five major needs for the future: (1) While there is a lot of data, little of it is focused sufficiently to define estuary responses to inflow in a way that there are clear connections between physical characteristics and biological responses, so a state-wide monitoring approach is needed. (2) The physics-based models of circulation that are typically applied to Texas bays and estuaries are not up to the current scientific methods, so 3-D models are needed as well as updated bathymetry, shoreline locations, and salinity monitoring to calibrate and validate the models. (3) More mechanistic studies are needed that specifically link the biological response to physical dynamics, and this will be easier if the prior recommendations are enacted. (4) Because of the semi-arid climate, there will never be enough water to dilute salinity in all bay systems, especially in central and south Texas, so a focused approach to protect key nursery habitats during droughts is needed. (5) Finally, the FWI standards are complex, 3-D, hydrology tables that are difficult to apply, so a simpler approach is needed that specifically is linked to biological outcomes. This last recommendation may be impossible to implement if the first four are not implemented. While enormous progress has been made in Texas, there is still more to do, but the history of these activities can serve as a guide to any organization interested in the conservation, restoration, enhancement, or protection of estuaries anywhere in the world.
Physical and Biogeochemical Conditions and Trends in Texas Estuaries
Authors: Hu Xinping , Yin Hang 
Published: January 2025

AbstractTo explore long-term changes in Texas estuaries, both physical (temperature and salinity) and biogeochemical parameters (dissolved oxygen, total organic carbon, total titration alkalinity, and pH) were examined for their long-term trends. Warming is found in all estuaries, consistent with observed warming in the Gulf of Mexico, and long-term salinity increase is also found in most of the examined stations, indicating a reduction in freshwater inflow, except in the northernmost estuary (i.e., Sabine Lake) and few secondary bays to the south, and the latter are subject to inflow management. Dissolved oxygen concentration decrease predominantly in mid-coast estuaries exceeds the extent that can be explained by warming and salinity increase, and this decrease appears to be consistent with the decrease in total organic carbon concentration. Freshwater inflow reduction may be responsible for the decrease in allochthonous organic carbon input, and both inflow-related nutrient reduction and nutrient pollution management also lead to reduced autochthonous organic carbon production. Freshwater inflow decline, the resulted increase in estuarine residence time, and associated more pronounced biogeochemical reactions may all contribute to total alkalinity consumption and increase in estuarine acidity. These changes highlight the importance of freshwater inflow on estuarine biogeochemistry in this climate transition zone, which requires sustained monitoring and continued investigations.
Introduction
Authors: Erbil Duygu , Rigney Ann , Vlessing Clara 
Published: January 2025

AbstractThis introductory essay situates the volume at the point of intersection between the fields of memory, life writing and social movements. It sets out an approach to life writing as a relational and intersubjective form of memory work that connects individual and collective experience. Using this framework and with reference to its seven case studies, it shows the value of life writing in activism, both in advocating for particular causes and in shaping the meaning of contentious action.
Can the Monster Speak? Ventriloquism and Voice in Trans Activist Life Writing
Authors: Poletti Anna 
Published: January 2025

AbstractThis chapter examines Paul B. Preciado’s use of life writing as a means of producing cultural memory about trans peoples’ encounters with the mental health profession. Using the framework of testimonial injustice developed by Miranda Fricker, it argues that Preciado’s 2020 book Can the Monster Speak? is an example of life writing that seeks to reposition trans people as holders of knowledge about gender and sexuality who have been wronged by the medical profession’s use of pathologising discourses that designate trans desires and subjectivities as illnesses requiring treatment. The chapter examines Preciado’s use of the aesthetic strategies of intertextuality and ventriloquism to narrate and contest the position of trans people as patients. It closely reads Preciado’s sustained interweaving of the characters and themes of the writing of Franz Kafka with the figure of the monster, which has a rich history in trans life writing and theory. The chapter shows how life writing can be a means of producing cultural memory from a subjugated position, in this case by repositioning trans subjects from having a place within the history of medical discourse as patients to being agents of memory who narrate the complex history of interactions between trans people and the medical profession.
Writing Louise Michel: The Formation and Development of a Mythologised Revolutionary
Authors: Vlessing Clara 
Published: January 2025

AbstractThis chapter looks at the cultural afterlives of the nineteenth-century anarchist Louise Michel (1830–1905). It argues that a dynamic of mythologisation has consistently underpinned the long durée recollection of Michel’s unequivocally contentious life. Through an overview of mediations of Michel’s life and person, from those produced during her lifetime to the present day, including both her memoirs and written accounts of her life by subsequent remembering subjects, the chapter shows that she has often been represented as a superlative or superhuman figure. Questioning the mechanisms behind and effects of Michel’s remembrance in hyperbolic and abstracted forms, it argues that Michel’s radicalism and gender have played a central role in her mythologisation.