bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informing a Canadian Skin Science Trainee Program Based on the State of Trainee Programs Offered by International Academic Societies
Authors: Brooks Stephanie G. , Pawluk Megan A. , Litvinov Ivan V. , Fradette Julie , Chan An-Wen , Philip Anie , Croitoru David , Richardson Katlyn C. 
Published: November 2022

Background For dermatology to effectively address the ever-growing medical needs, longstanding communication barriers across investigators working in different research pillars and practicing clinicians must be improved. To address this problem, trainee-specific programs are now evolving to align their educational landscape across basic science, translational and clinical research programs. Objectives To establish a Skin Investigation Network of Canada (SkIN Canada) training roadmap for the career and skill development of future clinicians, clinican scientists and basic scientists in Canada. This Working Group aims to strengthen and harmonize collaborations and capacity across the skin research community. Methods The Working Group conducted a search of established international academic societies which offered trainee programs with mandates similar to SkIN Canada. Societies’ program items and meetings were evaluated by use of an interview survey and/or the collection of publicly available data. Program logistics, objectives and feedback were assessed for commonalities and factors reported or determined to improve trainee experience. Results Through the various factors explored, the Working Group discovered the need for increasing program accessibility, creating opportunities for soft skill development, emphasizing the importance of current challenges, collecting and responding to feedback, and improving knowledge sharing to bridge pillars of skin research. Conclusions Although improvements have been made to trainee education in recent years, a plurality of approaches exist and many of the underlying roadblocks remain unresolved. To establish fundamental clinician-basic scientist collaboration and training efforts, this Working Group highlights important factors to include and consider in building a trainee program and emphasizes the importance of trainee education.
Assessing the potential for virtualizable care in the pediatric emergency department
Authors: Osmanlliu Esli , Burstein Brett , Tamblyn Robyn , Buckeridge David L 
Published: November 2022

Introduction There is increasing interest for patient-to-provider telemedicine in pediatric acute care. The suitability of telemedicine (virtualizability) for visits in this setting has not been formally assessed. We estimated the proportion of in-person pediatric emergency department (PED) visits that were potentially virtualizable, and identified factors associated with virtualizable care. Methods This was a retrospective analysis of in-person visits at the PED of a Canadian tertiary pediatric hospital (02/2018–12/2019). Three definitions of virtualizable care were developed: (1) a definition based on “resource use” classifying visits as virtualizable if they resulted in a home discharge, no diagnostic testing, and no return visit within 72 h; (2) a “diagnostic definition” based on primary ED diagnosis; and (3) a stringent “combined definition” by which visits were classified as virtualizable if they met both the resource use and diagnostic definitions. Multivariable logistic regression was used to identify factors associated with telemedicine suitability. Results There were 130,535 eligible visits from 80,727 individual patients during the study period. Using the most stringent combined definition of telemedicine suitability, 37.9% (95% confidence interval (CI) 37.6%–38.2%) of in-person visits were virtualizable. Overnight visits (adjusted odds ratio (aOR) 1.16–1.37), non-Canadian citizenship (aOR 1.10–1.18), ethnocultural vulnerability (aOR 1.14–1.22), and a consultation for head trauma (aOR 3.50–4.60) were associated with higher telemedicine suitability across definitions. Discussion There is a high potential for patient-to-provider telemedicine in the PED setting. Local patient and visit-level characteristics must be considered in the design of safe and inclusive telemedicine models for pediatric acute care.
Adjuvant chemotherapy improves survival in high-risk stage II colon cancer: a retrospective cohort study
Authors: Liu Lin-Lin , Xiang Zuo-Lin 
Published: November 2022

Background: The survival advantage of postoperative chemotherapy for high-risk stage II colon cancer (CC) patients remains unclear. Objectives: The purpose was to evaluate the survival of high-risk stage II CC cases treated with chemotherapy and to construct survival prediction models to predict the survival benefit from chemotherapy. Design: The study is a retrospective observational cohort study. Methods: Data on patients with stage II CC diagnosed from 2005 to 2019 who underwent radical surgery were obtained from the Surveillance, Epidemiology and End Results (SEER) database. A 1:1 propensity score matching (PSM) was applied to obtain two cohorts, chemotherapy versus no chemotherapy. A chi-square analysis was used to assess the differences before and after PSM in the above two groups. Kaplan–Meier survival analysis and Cox proportional hazards regression were applied to investigate the 5- and 10-year overall survival (OS) and cancer cause-specific survival (CSS). The predictive power of the constructed models was assessed by the concordance index (C-index) and calibration curves. Results: Of the 37,050 cases, 14,744 (39.8%) stage II CC were at high-risk and 29.2% of them received chemotherapy. Age, T stage, marital status, histologic grade, gender, and site independently influenced the reception of chemotherapy. The survival advantage of chemotherapy in the high-risk patients remained positive before and after PSM. The estimated 3, 5, and 10 years OS rates of chemotherapy group were 9.3, 10.7, and 15.6% higher than the nonchemotherapy group, respectively. Four nomograms predicting OS and CSS were established, with great discrimination (C-index between 0.627 and 0.691) and excellent calibration. Conclusion: Postoperative chemotherapy is beneficial for high-risk stage II CC patients, including the elderly patients (over 65 years of age). Our study developed nomograms to quantify the survival benefit of chemotherapy among high-risk stage II CC patients to develop personalized treatment recommendations and guide management decisions.
Treatment of cerebral aneurysms with flow diversion or stent assisted coiling in patients on concurrent oral anticoagulation
Authors: Krishnakumar Hari , Mascitelli Justin , Hassan Ameer , Leary Jonathan , Son Colin 
Published: November 2022

Background Flow diversion and stent assisted coiling are increasingly utilized strategies in the endovascular treatment of cerebral aneurysms. Ischemic and hemorrhagic complications play an important role in the outcome following such embolizations. Little is published regarding patients on concurrent oral anticoagulation and undergoing such embolizations and the rates of complications and patient outcomes. Materials and Methods Retrospective data for consecutive patients on concurrent oral anticoagulation undergoing flow diversion or stent assisted coiling for cerebral aneurysms was accessed from databases at the participating sites. Patient demographics, comorbidities, antiplatelet regimens, aneurysm characteristics, complications, and radiographic results were recorded and descriptive statistics reported. Results Eleven patients were identified undergoing embolization in the setting of preoperative anticoagulant use and included seven patients undergoing flow diversion and four patients undergoing stent assisted coiling. There was a wide range of antiplatelet and anticoagulant management strategies. There were four major complications in three patients (27.2%) to include two serious bleeding events in addition to ischemic strokes. Both serious bleeding events occurred in patients continued on oral anticoagulation with the addition of antiplatelets. At a mean follow-up of 9.6 months, three aneurysms had continued filling for a good radiographic outcome of 72.7%. Conclusions Anticoagulant and antiplatelet use in the setting of flow diversion or stent assisted coiling may carry increased risks as compared to historical norms and, for flow diversion, offer decreased efficacy.
Incremental value of the combined brain-cardiac CT protocol on prediction of atrial fibrillation after stroke
Authors: Braillon Alexandra , Bernard Angélique , Leclercq Thibault , Duloquin Gauthier , Pommier Thibaut , Benali Karim , Comby Pierre-Olivier , Loffroy Romaric , Midulla Marco , Ricolfi Frédéric , Béjot Yannick , Guenancia Charles 
Published: November 2022

Introduction: Atrial fibrillation (AF) is one of the most common causes of ischemic stroke. It is essential to target patients at highest risk of AF detected after stroke (AFDAS), who should benefit from a prolonged rhythm screening strategy. Cardiac-CT angiography (CCTA) was added to the stroke protocol used in our institution in 2018. We sought to assess, for AFDAS, the predictive value of atrial cardiopathy markers by a CCTA performed on admission for acute ischemic stroke. Patients and Methods: From November 2018 to October 2019, consecutive stroke patients with no history of AF were included. Let atrial volume (LAV), epicardial adipose tissue (EAT) attenuation and volume, and LAA characteristics were measured on CCTA. The primary endpoint was the presence of AFDAS at follow-up, diagnosed by continuous electrocardiographic monitoring, long-term external Holter monitoring during hospital stay, or implantable cardiac monitor (ICM). Results: Sixty of the 247 included patients developed AFDAS. Multivariable analysis shows independent predictors of AFDAS: age >80 years (HR 2.46; 95%CI (1.23–4.92), p = 0.011), indexed LAV >45 mL/m2 (HR 2.58; 95%CI (1.19–5.62), p = 0.017), EAT attenuation > −85HU (HR 2.16; 95%CI (1.13–4.15), p = 0.021) and LAA thrombus (HR 2.50; 95%CI (1.06–5.93), p = 0.037). Added consecutively to AFDAS prediction AS5F score (combining age and NIHSS >5), these markers had an incrementally better predictive value compared with the global Chi2 of the initial model ( p = 0.001, 0.035, and 0.015 respectively). Discussion and conclusion: Adding CCTA to the acute stroke protocol to assess markers of atrial cardiopathy associated with AFDAS may help to better stratify the AF screening strategy, including the use of an ICM.
The effects of Ziziphus Spina leaves’ Hydro-Alcoholic Extract Vaginal Cream and Clotrimazole on Candida albicans in Wistar Rats
Authors: Honarmandpour Azam , Fatahinia Mahnaz , Masoud Keshavarzzade Amir , Namjoyan Forogh , Maraghi Elham , Kamali Hossein 
Published: November 2022

Background: In vitro, Ziziphus Spina-Christi (ZSC) leaves have been shown to have antimicrobial and antifungal effects. This study aimed to examine the effects of Ziziphus Spina leaves hydro-alcoholic extracts with Clotrimazole against Candida albicans in female rats. Methods: Four groups of rats were infected vaginally with C. Albicans, and 1 group not infected was considered negative control. The infected groups received the following treatments: 2 groups were treated with vaginal 5%, or 10%, of Ziziphus Spina extract creams. One group received 1% clotrimazole, and 1 group did not receive any treatment considered a positive control. Results: The mean number of colony-forming units (CFUs) before the intervention was 195.83 ± 395.126 in the 5% ZSC group, 346.33 ± 396.719 in the 10% ZSC group, 345.17 ± 507.431 in the clotrimazole group, 212.20 ± 148.304 in the positive control group ( P = .604), and 0 in the negative control group ( P = .003). After 1 week, the average number of CFUs considerably dropped to 65.14 ± 36.03 in the 5% ZSC group, 1.43 ± 3.60 in the 10% ZSC group, and 0.43 ± 1.13 in the clotrimazole group. The number in the positive control group remained unchanged (212.20 ± 148.304) ( P = .005). After 2 weeks, the average number of CFUs was 0 in the 10% ZSC group, Clotrimazole and negative control groups and was 4.57 ± 23.99 in the 5% ZSC group ( P < .001). Conclusions: Our findings indicated that the effectiveness of Vaginal creams containing 10% Ziziphus Spina is similar to Clotrimazole in eliminating C. Albicans.
Mineralogy of the scheelite-bearing ores of Monte Tamara, SW Sardinia: insights for the evolution of a Late Variscan W–Sn skarn system
Authors: Deidda Matteo L. , Naitza Stefano , Moroni Marilena , De Giudici Giovanni B. , Fancello Dario , Idini Alfredo , Risplendente Andrea 
Published: November 2022

AbstractSouthwestern Sardinia, Italy, hosts several skarn, W–Sn–Mo greisen and hydrothermal deposits related to a 289±1 Ma Late Variscan granite suite. Among them, the most representative scheelite-bearing skarns belong to the San Pietro and Sinibidraxiu localities, in the Monte Tamara area, Sulcis region. The San Pietro deposit is a typical calc-silicate skarn whereas Sinibidraxiu is a sharply bounded orebody hosted in a marble unit. Optical petrographic observations and compositional data of major and trace elements were obtained for samples from both localities. San Pietro data suggests evolution from an oxidising prograde skarn stage (andradite–diopside, hematite and scheelite), to progressively more reducing conditions from the early retrograde (magnetite–cassiterite) to the late sulfide stage (arsenopyrite, stannite, molybdenite, Bi sulfosalts and Zn–Cu–Pb–Fe sulfides); Sinibidraxiu has diffuse carbonate–quartz intergrowths pseudomorphic over an early mineral assemblage with fibrous habit, followed by abundant ore mineral precipitation under reducing conditions (scheelite, arsenopyrite and Pb–Zn–Cu–Fe sulfides). Geothermometers indicate a comprehensive temperature range of 460–270°C for the sulfide stages of both deposits. The differences between the two deposits might be controlled by the distance from the source intrusion coupled with the different reactivity of the host rocks. The San Pietro mineralogy represents a more proximal skarn, contrasting with more distal mineralogical and chemical features characterising the Sinibidraxiu orebody (lack of Mo–Sn–Bi phases; LREE–MREE–HREE signature of scheelite). This investigation contributes for the first time to the identification of a W–Sn skarn system in SW Sardinia, thereby suggesting the Monte Tamara area and its surroundings as favourable for further exploration.
Gysinite-(La), PbLa(CO3)2(OH)⋅H2O, a new rare earth mineral of the ancylite group from the Saima alkaline complex, Liaoning Province, China
Authors: Wu Bin , Gu Xiang-ping , Rao Can , Wang Ru-cheng , Xing Xing-qing , Wan Jian-jun , Zhong Fu-jun , Bonnetti Christophe 
Published: November 2022

AbstractThe new mineral, gysinite-(La), with the ideal formula PbLa(CO3)2(OH)⋅H2O, has been discovered in lujavrite from the Saima alkaline complex, Liaoning Province, China. It commonly occurs as subhedral to anhedral, granular and platy crystals of 5 to 50 μm in size, in interstices or enclosed in microcline, aegirine and nepheline. Associated minerals include nepheline, aegirine, microcline, natrolite, eudialyte, lamprophyllite, bastnäsite-(Ce), parasite-(Ce), ancylite-(La), ancylite-(Ce), bobtraillite, britholite-(Ce), thorite, calcite and galena. The crystallisation of gysinite-(La) may be related to the post-magmatic carbonation event. Gysinite-(La) crystals are generally transparent, colourless, or pale yellow, with a vitreous lustre and white streak. It is brittle with an uneven fracture, and the estimated Mohs hardness is 3½ to 4. The calculated density is 5.007 g/cm3. Optically, gysinite-(La) is biaxial (–), α= 1.832(2), β= 1.849(4), γ = 1.862(5) in white light and 2Vmeas = 81.6°. The empirical formula of gysinite-(La) is (La0.93Pb0.61Nd0.23Pr0.14Sr0.04Gd0.02Sm0.01Eu0.01Ca0.01)Σ2(CO3)2(OH)1.34⋅0.66H2O, which is calculated on the basis of general formula (REExM2+2–x)(CO3)2(OH)x⋅(2–x)H2O. The strongest eight lines of its powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are: 5.596 (21) (011), 4.349 (100) (110), 3.732 (68) (111), 2.984 (61) (121), 2.667 (21) (031), 2.363 (48) (131), 2.090 (29) (221) and 2.028 (21) (212). Gysinite-(La) is orthorhombic, in the space group Pmcn, and unit-cell parameters refined from single-crystal X-ray diffraction data are: a = 5.0655(2) Å, b = 8.5990(3) Å, c = 7.3901(4) Å, V = 321.90(2) Å3 and Z = 2. It is a new member of the ancylite group and isostructural with gysinite-(Nd), but with La and Pb dominant in the metal cation sites in the structure.
Levofloxacin prophylaxis vs no prophylaxis in patients with neutropenia within an endemic country for carbapenem-resistant GNB
Authors: Clerici Daniela , Galli Laura , Greco Raffaella , Lugli Anna P. , Erbella Federico , Ripa Marco , Tassan Din Chiara , Nitti Rosamaria , Giglio Fabio , Mastaglio Sara , Lorentino Francesca , Xue Elisabetta , Farina Francesca , Liberatore Carmine , Poli Andrea , Carletti Silvia , Lupo Stanghellini Maria T. , Carrabba Matteo G. , Assanelli Andrea A. , Ruggeri Annalisa , Bernardi Massimo , Corti Consuelo , Peccatori Jacopo , Mancini Nicasio , Scarpellini Paolo , Ciceri Fabio , Castagna Antonella , Oltolini Chiara 
Published: November 2022

Abstract
Fluoroquinolone prophylaxis’s (FQ-P) usefulness in patients with neutropenia is controversial. In recent decades, Italian epidemiological data has shown worrisome rates of FQ resistance. A single-center cohort study on 136 autologous stem cell transplantations (ASCTs) and 223 allogeneic hematopoietic stem cell transplantations (allo-HSCTs) was performed from January 2018 to December 2020. Piperacillin/tazobactam was the first-line therapy for febrile neutropenia (FN). Since February 2019, FQ-P has been omitted. We evaluated the day +30 posttransplant cumulative incidence function (CIF) of gram-negative bacteria pre-engraftment bloodstream infections (PE-BSIs) and any changes in antimicrobial resistance, FN, and infection-related mortality (IRM). In ASCTs, ≥1 FN episode occurred in 74.3% of transplants, without differences among groups (P = .66). CIF of gram-negative bacteria PE-BSI was 10.1%, with a significant difference according to FQ-P (0% [LEVO-group] vs 14.1% [NO-LEVO-group], P = .016). CIF of IRM was 0% in both groups. In allo-HSCTs, ≥1 FN episode occurred in 96.4% of transplants, without differences among groups (P = .72). CIF of gram-negative bacteria PE-BSI was 28%, significantly higher without FQ-P (14.7% [LEVO-group] vs 34.4% [NO-LEVO-group], P = .003). CIF of IRM was 5%, superimposable in both groups (P = .62). Comparing antimicrobial resistance among gram-negative bacteria of allo-HSCT setting, in the group without FQ-P, a significantly higher proportion of pathogens was susceptible to piperacillin/tazobactam (71% vs 30%, P = .026), FQ (49% vs 10%, P = .03), and carbapenems (95% vs 50%, P = .001). FQ-P discontinuation increased gram-negative bacteria PE-BSI but did not impact IRM, both in the ASCT and allo-HSCT settings; importantly, it concurred to significantly decrease antimicrobial resistance in gram-negative bacteria.
Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan
Authors: Chen Shih-Pin , Hsu Chia-Lin , Wang Yen-Feng , Yang Fu-Chi , Chen Ting-Huei , Huang Jia-Hsin , Pan Li-Ling Hope , Fuh Jong-Ling , Chang Hsueh-Chen , Lee Yi-Lun , Chang Hung-Ching , Lee Ko-Han , Chang Yu-Chuan , Fann Cathy Shen-Jang , Wang Shuu-Jiun 
Published: November 2022

Abstract
Background
Cluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies (GWAS) recently identified replicable genomic loci for cluster headache in Europeans, but the genetic underpinnings for cluster headache in Asians remain unclear. The objective of this study is to investigate the genetic architecture and susceptibility loci of cluster headache in Han Chinese resided in Taiwan.

Methods
We conducted a two-stage genome-wide association study in a Taiwanese cohort enrolled from 2007 through 2022 to identify the genetic variants associated with cluster headache. Diagnosis of cluster headache was retrospectively ascertained with the criteria of International Classification of Headache Disorders, third edition.
Control subjects were enrolled from the Taiwan Biobank. Genotyping was conducted with the Axiom Genome-Wide Array TWB chip, followed by whole genome imputation. A polygenic risk score was developed to differentiate patients from controls. Downstream analyses including gene-set and tissue enrichment, linkage disequilibrium score regression, and pathway analyses were performed.

Results
We enrolled 734 patients with cluster headache and 9,846 population-based controls. We identified three replicable loci, with the lead SNPs being rs1556780 in CAPN2 (odds ratio = 1.59, 95% CI 1.42‒1.78, p = 7.61 × 10–16), rs10188640 in MERTK (odds ratio = 1.52, 95% CI 1.33‒1.73, p = 8.58 × 10–13), and rs13028839 in STAB2 (odds ratio = 0.63, 95% CI 0.52‒0.78, p = 2.81 × 10–8), with the latter two replicating the findings in European populations. Several previously reported genes also showed significant associations with cluster headache in our samples. Polygenic risk score differentiated patients from controls with an area under the receiver operating characteristic curve of 0.77. Downstream analyses implicated circadian regulation and immunological processes in the pathogenesis of cluster headache.

Conclusions
This study revealed the genetic architecture and novel susceptible loci of cluster headache in Han Chinese residing in Taiwan. Our findings support the common genetic contributions of cluster headache across ethnicities and provide novel mechanistic insights into the pathogenesis of cluster headache.
Gene expression profile of placentomes and clinical parameters in the cows with retained placenta
Authors: Moradi Mehdi , Zhandi Mahdi , Sharafi Mohsen , Akbari Arvand , Atrabi Mohammad Jafari , Totonchi Mehdi 
Published: November 2022

Abstract
Background
Retained placenta (RP) is a prevalent disorder in cattle with many health-related and economic costs for the farm owners. Its etiology has not been clarified yet and there is no definite therapy for this disorder. In this study we conducted RNA-seq, hematologic and histologic experiments to survey the causes of RP development.

Methods
Blood samples were collected from 4 RP and 3 healthy cows during periparturtion period for hematological assessments followed by placentome sampling within 30 min after parturition. Cows were grouped as RP and control in case the placenta was retained or otherwise expelled, respectively. Total RNA was extracted from placentome samples followed by RNA-sequencing.

Results
We showed 240 differentially expressed genes (DEGs) between the RP and control groups. Enrichment analyzes indicated immune system and lipid metabolism as prominent over- and under-represented pathways in RP cows, respectively. Hormonal assessments showed that estradiol-17β (E2) was lower and cortisol tended to be higher in RP cows compared to controls at the day of parturition. Furthermore, histologic experiment showed that villi-crypt junctions remain tighter in RP cows compared to controls and the crypts layer seemed thicker in the placentome of RP cows. Complete blood cell (CBC) parameters were not significantly different between the two groups.

Conclusion
Overall, DEGs derived from expression profiling and these genes contributed to enrichment of immune and lipid metabolism pathways. We suggested that E2 could be involved in development of RP and the concentrations of P4 and CBC counts periparturition might not be a determining factor.