bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfil clínico psiquiátrico e sociodemográfico de idosos com transtorno de humor depressivo
Authors: Bennemann Fernanda Ziegler , Engroff Paula , Dannebrock Letícia Güenter , Diefenthaeler Edgar Chagas , Sgnaolin Vanessa , Neto Alfredo Cataldo 
Published: September 2022

Objetivos: descrever o perfil clínico e sociodemográfico de idosos portadores de transtorno de humor depressivo. Métodos: estudo transversal, que abrangeu os dados da primeira consulta de todos os indivíduos com idade igual ou superior a 60 anos atendidos no ambulatório de Psiquiatria Geriátrica de um hospital terciário, no período de 2014 a 2019, com diagnóstico de depressão. Os aspectos clínicos psiquiátricos avaliados foram a razão da procura por atendimento, a presença de alguma comorbidade clínica, as internações psiquiátricas prévias e o diagnóstico de depressão unipolar estabelecido com base no DSM-5. As informações sociodemográficas foram idade, sexo, estado civil, escolaridade e atividade laboral. Resultados: um total de 119 participantes com diagnóstico de Transtorno Depressivo Maior foram inseridos no estudo. A média de idade foi de 70,9±7,4 anos e 83,2% do sexo feminino. Os homens depressivos eram, na sua maioria, da faixa etária dos 70 aos 79 anos, enquanto as mulheres eram mais jovens (60 aos 69 anos). Os idosos mais jovens com depressão eram casados (52,9%), enquanto os mais velhos eram viúvos. Em relação à escolaridade, os idosos mais velhos tinham menos anos de estudo. Grande parcela dos idosos com depressão apresentava algum tipo de comorbidade clínica (86,4%).Conclusões: assim, com envelhecimento da população, conhecê-la com maior aprofundamento torna-se uma ferramenta útil para melhor tratá-la. Além disso, quanto mais conhecimento possuímos melhor conseguimos otimizar nossos recursos.
Parameters of complete blood count, lipid profile and their ratios in predicting obstructive coronary artery disease in patients with non-ST elevation acute coronary syndrome
Authors: Tsivanyuk M. M. , Geltser B. I. , Shakhgeldyan K. I. , Vishnevskiy A. A. , Shekunova O. I. 
Published: September 2022

Aim. To evaluate the predictive potential of the parameters of complete blood count (CBC), lipid profile and their ratios for predicting obstructive coronary artery disease (oCAD) in patients with non-ST elevation acute coronary syndrome (NSTEACS).Material and methods. The study included 600 patients with NSTE-ACS with a median age of 62 years who underwent invasive coronary angiography (CA). Two groups were formed, the first of which consisted of 360 (60%) patients with oCAD (stenosis ≥50%), and the second — 240 (40%) with coronary stenosis <50%. The clinical and functional status of patients before CAG was assessed by 33 parameters, including parameters of CBC, lipid profile and their ratio. For statistical processing and data analysis, the Mann-Whitney, Fisher, chi-squared tests, univariate logistic regression (LR) were used, while for the creation of predictive models, multivariate LR (MLR) was used. The quality was assessed by 4 metrics: area under the ROC curve (AUC), sensitivity (Se), specificity (Sp), and accuracy (Ac).Results. CBC and lipid profile analysis made it possible to identify factors that are linearly and non-linearly associated with oCAD. Univariate LR revealed their threshold values with the highest predictive potential. The quality metrics of the best prognostic model developed using MLR were as follows: AUC — 0,80, Sp — 0,79, Ac — 0,76, Se — 0,78. Its predictors were 8 following categorical parameters: age >55 years in men and >65 years in women, lymphocyte count (LYM) <19%, hematocrit >49%, immune-inflammation index >1000, high density lipoprotein cholesterol (HDL-C) to low density lipoprotein cholesterol (LDL-C) ratio <0,3, monocyte (MON)-to-HDL-C ratio >0,8, neutrophil (NEUT)-to-HDL-C ratio >5,7 and NEUT/LYM >3. The relative contribution of individual predictors to the development of end point was determined.Conclusion. The predictive algorithm (model 9), developed on the basis of MLR, showed a better quality metrics ratio than other models. The following 3 factors had the dominant influence on the oCAD risk: HDL-C/LDL-C (38%), age of patients (31%), and MON/HDL-C (14%). The influence of other factors on the oCAD risk was less noticeable.
Left atrial strain in assessing heart failure with preserved ejection fraction in hypertensive patients
Authors: Mazur E. S. , Mazur V. V. , Bazhenov N. D. , Nilova O. V. , Nikolaeva T. O. 
Published: September 2022

Aim. To compare the results of diagnosing heart failure with preserved ejection fraction (HFpEF) in patients with hypertension (HTN) according left atrial (LA) strain values with the results obtained using the H2FPEF score and diastolic stress testing (DST).Material and methods. The study included 293 patients with previously established HTN who were examined due to complaints of shortness of breath and/or palpitations (men, 97 (33,5%), mean age, 62,0 (55,0; 67,0) years). All patients underwent transthoracic echocardiography with the assessment of LA strain parameters and probability of HFpEF using the H2FPEF score. Eighty five patients with an intermediate probability of HFpEF underwent DST.Results. A low probability of HFpEF according to the H2FPEF score was registered in 35 (11,9%) patients, uncertain — in 206 (70,3%), high — in 52 (17,7%). DST was negative in 43 (50,6%) and positive in 42 (49,4%) patients with an intermediate probability of HFpEF. LA strain in the reservoir phase in patients with a low probability of HFpEF averaged (median and interquartile interval) 28,0 (23,6; 31,5)%, while in patients with an intermediate probability and negative DST — 24,0 (22,0; 26,8)%, with an intermediate probability and positive DST — 20,0 (18,0; 21,0)%, and with a high probability of HFpEF — 19,6 (16,9; 21,8)%. HFpEF was diagnosed in 94 patients, including 52 with a high probability on the H2FPEF score and 42 with an intermediate probability and positive DST. The diagnosis of HFpEF was ruled out in 78 patients, including 35 with a low probability on the H2FPEF score and 43 with an intermediate probability and negative DST. Further, 172 patients with confirmed or excluded HFpEF were randomly divided into two equal cohorts. In the training cohort, HFpEF was diagnosed in 44 (51,2%) patients, in the validation cohort — in 50 (58,1%). ROC analysis performed on the training cohort for the LA strain in reservoir phase showed AUC of 0,920 (95% confidence interval (CI), 0,842-0,968) and cut-off point of 21,5%. In the training cohort, the results of HFpEF diagnosis using the indicated criterion coincided with those using H2FPEF score and DST in 86,1% (95% CI, 77,2-91,8) of cases. The Cohen’s kappa was 0,721 (95% C,I 0,575-0,868). In the validation cohort, agreement was observed in 84,9% (95% CI 75,8-91,0) of cases with Cohen’s kappa of 0,702 (95% CI 0,553-0,851).Conclusion. In hypertensive patients, the diagnosis of HFpEF made on the basis of a decrease in the LA strain in reservoir phase to ≤21,5%, is in good agreement with the diagnosis made using the H2FPEF score and DST.
Efficacy and safety of left atrial appendage closure in patients with atrial fibrillation and high thromboembolic and bleeding risk
Authors: Pevzner D. V. , Semenova A. А. , Kostritsa N. S. , Merkulova I. A. , Komarov A. L. , Merkulov E. V. 
Published: September 2022

Aim. To compare the incidence of thromboembolic and hemorrhagic events after left atrial appendage occlusion (LAAO) or without prevention of thromboembolic events (TEEs) during prospective follow-up of patients with atrial fibrillation (AF) and a high risk of ischemic stroke (IS) who have contraindications to long-term anticoagulant therapy.Material and methods. The study included 134 patients with AF, a high risk of IS, and contraindications to long-term anticoagulation. Patients were divided into 2 groups as follows: the first group included patients who underwent LAAO (n=74), while the second one — those who did not undergo any TEE prevention (n=60). The follow-up period was 3 years. The cumulative rate of all-cause mortality, IS, transient ischemic attacks (TIA), and systemic embolism (SE) was taken as the primary efficacy endpoint. The primary safety endpoint included major bleeding according to GARFIELD registry criteria.Results. The rate of composite efficacy endpoint in the LAAO group was significantly lower than in the group without thromboembolic prophylaxis (5,2 vs 17,4 per 100 patient-years; adjusted odds ratio (OR), 4,08; 95% confidence interval (CI): 1,7-9,5; p=0,001). The rate of major bleeding was comparable in both groups (2,4 in the LAAO group vs 1,3 per 100 patient-years in the group without thromboembolic prophylaxis; adjusted OR, 0,55; 95% CI: 0,1-3,09; p=0,509). In addition, the event rate of net clinical benefit (all-cause mortality + ischemic stroke/TIA/SE + major bleeding) in the LAAO group was also significantly lower (5,9 vs 18,2 per 100 patient-years; adjusted OR, 3,0; 95% CI: 1,47-6,36; p=0,003).Conclusion. Among patients with AF and contraindications to long-term anticoagulation after 3 years of follow-up, LAAO demonstrated the significant reduction of cumulative rate of all-cause mortality and non-fatal thromboembolic events. At the same time, the frequency of major bleeding was comparable between the groups, even taking into account access-site bleeding and postoperative antithrombotic therapy (ATT)-associated bleeding in the LAAO group. Further randomized clinical trials are required to confirm these data.
La negativa a recibir una transfusión de sangre por motivos religiosos en los menores de edad, en España
Authors: Barcia Lehmann Rodrigo , Rivera Restrepo José Maximiliano 
Published: September 2022

En este trabajo se pretende indagar en torno a la negativa de los Testigos de Jehová en cuanto a la aplicación de tratamientos de transfusión sanguínea,particularmente en menores de edad. Se analizará la legislación española y algunas soluciones del derecho comparado. En síntesis, tratándose de los menores de edad se debe atender a la autonomía progresiva, con el fin de establecer si ellos pueden adoptar decisiones que les pudieren perjudicar susalud. Se propone revisar la legislación y doctrina españolas sobre la materia, con el fin de articular una adecuada solución a la hipótesis de trabajo. Se plantea analizar concienzudamente las fuentes primaras y secundarias sobre la negativa a recibir una transfusión sanguínea en los menores de edad, en España.
La fundamentación de los deberes morales y jurídicos desde un punto de vista indígena: el caso de dos comunidades indígenas de Colombia
Authors: Chindoy Chindoy Juan Alejandro 
Published: September 2022

A partir del ejemplo del rol de la oralidad en la fundamentación del deber moral y jurídico en los pueblos nativos kamëntšá e inga, asentados en el suroccidente colombiano, este artículo de reflexión se propone como objetivo principal mostrar que la narrativa oral indígena funciona como una forma distintiva de argumentación que da fundamento objetivo a los deberes morales y jurídicos de una comunidad. Usando el método histórico-hermenéutico, con un enfoque de análisis documental, se muestran dos resultados significativos. El primero es que una conceptualización adecuada sobre la caracterización de la narrativa oral indígena tanto desde la perspectiva de la filosofía occidental como desde un punto de vista indígena conduce a la tesis de que la fundamentación de los deberes morales y jurídicos en las comunidades kamëntšá e inga tiene un carácter eminentemente dialógico. Un resultado adicional del análisis interpretativo es que la narrativa oral indígena es una forma de argumentación que no implica una ciega obediencia atávica. Finalmente, se concluye indicando que la fundamentación de los deberes morales y jurídicos de las comunidades kamëntšá e inga es formalmente similar a la fundamentación que han usado las tradiciones jurídicas más representativas de occidente, pero materialmente disímil tantopor su énfasis comunitario como su marcado carácter objetivo de los valores.
Ceramic cantilever bridge: A simplified clinical technique
Authors: Chraibi Rime , Hanine Yasmine , Cherkaoui Amine , Soualhi Hicham 
Published: September 2022

The anterior single missing tooth is a challenge to the dental surgeon when it comes to functional, aesthetic and biological integration especially when in adolescents or young adults, where passive eruption of the tooth is still active and where implant placement must be postponed. As a temporary or a long-term treatment, a fixed prosthesis can be placed, but in the era of maximum tissue preservation, dental practice is moving towards a harmless and conservative prosthetic therapy “the cantilever bonded bridge”.The indication is limited to the replacement of central or lateral maxillary incisor and mandibular incisors and therefore requires following a precise and rigorous clinical protocol. This article will discuss a simplified clinical realization of the ceramic cantilever bridge.The use of cantilever bonded bridges (single retainer) seems to be an excellent alternative compared to other therapeutic solutions.
Comparing the efficacy of lycopene & lycopene with hyaluronidase in management of oral sub mucous fibrosis-A clinical study
Authors: Asdullah Md. , Gupta Juhi , Khan Shahla , Yadav Prommod , Salati Nasir A , Verma Prathuman 
Published: September 2022

Oral submucous fibrosis (OSMF) is a scarring disease of the oral cavity that develops over time. Lycopene is a potent antioxidant found in tomatoes that has the best singlet oxygen quenching capability and a strong capacity to quench other free radicals in vitro of all the dietary carotenoids. A protein called hyaluronidase, which is found in mammalian sperm and testes, hydrolyzes hyaluronic acid to alter the permeability of connective tissue.To determine the effectiveness of lycopene and lycopenehyaluronidase in treating OSMF, as well as a comparison of their effectiveness.: 45 people with OSMF were enrolled in the study and divided into three groups. Patients in Group A received two evenly divided doses of Lycored 16 mg twice daily for three months. Patients in Group B received LycoRed and a 1500 IU intralesional injection of hyaluronidase twice a week for three months. Patients in Group C received placebo pills. The patients were evaluated at the end of three months. We observed the opening of the mouth, visual examination, palpatory findings, and burning sensation.For lycopene and lycopene–hyaluronidase combination, there was a statistically significant difference in mouth opening and burning sensation compared to placebo.
Pathology, Classification, Clinical Manifestations and Prognosis of Langerhan’s Cell Histiocytosis: A Single Center Experience
Authors: HASBAY Bermal , KOÇER Emrah , KAYASELÇUK Fazilet , CANPOLAT Tuba , BUYUKKURT Nurhilal , ERBAY Ayşe 
Published: September 2022

Objective: The aim of the study is to raise awareness about clinical features,
histopathological and radiological analyzes and treatment details of this rare
disease.
Methods: A total of 55 Langerhans cell histiocytosis patients, diagnosed
between the years 2006 and October 2020 in our department were included in the
study. The patients were evaluated in terms of age, gender, tumor localization,
risk groups, treatment modalities, recurrence, and disease outcome.
Results: Twenty-three out of 55 patients were children and 32 were adults. The
ages of the patients were between 7 months and 72 years. Thirty-seven of the
cases were male and 18 were female. The most common clinical complaint in
both groups was pain and swelling. The duration between the onset of the patient
complaints and admission to the hospital varies between 7 days-12 months in
children, and 10 days-23 years in adults. Forty-three of the cases had single-organ
involvement and 12 had multiorgan involvement. The most frequently affected
organ in both groups was bone. Forty of the 55 patients had follow-up data and
the treatment modalities are as follows: Nine patients radiotherapy, 8 patients
chemotherapy+steroid, 7 patients chemotherapy, 2 patients
chemotherapy+radiotherapy+steroid, 1 patient steroid, and 2 patients
chemotherapy+radiotherapy. Eleven patients were followed up without
additional treatment after surgery. Median follow-up from the time of biopsy
was 45.9 months in children and 41.9 months in adults.
Conclusions: As a result, diagnosis requires a high degree of suspicion and final
diagnosis is based on the histological examination of the lesions and biopsies
The development of analytical rubrics: An avenue to assess students' mathematical reasoning behavior
Authors: Rohati Rohati , S. Kusumah Yaya , Kusnandi Kusnandi 
Published: September 2022

A rubric is a logical set of criteria that teachers can use to evaluate students to determine criteria for obtaining complex competencies. Therefore, this study was conducted to develop a rubric and assess its effectiveness in evaluating students' mathematical reasoning behavior when solving mathematical problems. This rubric was developed based on four stages: reflecting, listing, grouping, and applying using generic model research design in education. Furthermore, the meta-rubric and expert input results are applied to improve its quality. The results showed that the rubric developed was able to consistently provide more feedback and provide teachers with additional opportunities to optimally assess the mathematical reasoning behavior of the students. This study recommends that there be further studies on the ability of teachers to understand students' mathematical reasoning levels to help students progress from the lowest level of reasoning to the highest level. In the end, students have creative mathematical reasoning abilities.

Keywords: Analytical Rubric, Behavior, Development, Mathematical Reasoning, Meta-Reasoning
A study of junior high school students’ attitudes and learning motivation on science process
Authors: Asrial Asrial , Maison Maison , Perdana Rahmat 
Published: September 2022

This study aims to determine the effect of students’ attitudes and motivation on science process skills. The type of research used is quantitative research with a research sample of 153 junior high school students. Sampling was selected using the purposive sampling technique with the criteria that junior high school students should have followed the science learning process and have attended science practicum in the school laboratory. The research instruments used were questionnaires and observation sheets with descriptive statistical data analysis techniques and inferential statistics. The results showed that students’ attitudes and learning motivation had an effect on science process skills as indicated by the correlation value between variables of 0.504 and the data significance value was smaller than 0.05, namely 0.000, so that the regression equation model could be obtained, namely Y = 2.612 + 0.492X1 + 644X2. This research was conducted to complement previous research. The novelty of this research is to see the effect of students’ attitudes and learning motivation on science process skills in science learning.

Keywords: Attitudes; Learning Motivation; Science Process Skills
Educating future primary schoolteachers to create a communication culture through educational technologies
Authors: Sharipkhojayeva Zhenisgul , Amirova Amina , Zhanar Abilkhairova , Tursynay Bainazarova , Meirimgul Yerkinbekova , Lyazzat Komekbayeva 
Published: September 2022

The purpose of this research is to get the opinions of teacher candidates to train future primary schoolteachers to create a communication culture through educational technologies. This study was created with the qualitative research method. The study group of the research consists of 40 teacher candidates studying in the primary school teaching department at various universities in Kazakhstan. Research data were collected with a semi-structured interview form developed by the researchers. As a result of the research, while the majority of primary schoolteacher candidates found themselves sufficient in using technology, they found themselves moderately competent in using educational technologies. In addition, the vast majority of teacher candidates consider themselves inadequate in providing education through educational technologies. The majority of primary schoolteacher candidates participating in the research stated that educational technologies have a positive effect on creating a communication culture. Primary schoolteacher candidates stated that programmes related to educational technologies and creating a communication culture should be developed in universities. It is necessary to implement the suggestions of pre-service teachers on improving the communication culture and to organise the education given at universities in this direction.
Keywords: Communication culture, educational technologies, primary schoolteacher candidates;
Validation of the academic burnout scale with the Rasch model
Authors: Setiyowati Arbin Janu , Rachmawati Indriyana , Prihatiningsih Riskiyana 
Published: September 2022

Academic burnout can cause exhaustion, frustration, lack of motivation and reduced academic ability in school. This research aims to develop an academic burnout scale with the Rasch model approach. The convenience sampling method was applied in taking samples, which involved 576 high school students. The research instrument used was the academic burnout scale. The analysis technique applied the Rasch model with the Winstep programme. The results of this research show that the developed academic burnout scale indicates better validity and reliability, and so it complies with the psychometric principles of psychology assessment instrument development. The research findings can be utilised as the instruments for student academic burnout assessment. Further experiments involving diverse subjects are necessary to improve the quality of the academic burnout scale’s items.
Keywords: Validation, scale, academic burnout, psychology assessment, Rasch model.
Influência da inclusão digital na alfabetização em saúde de idosos
Authors: Polonski Tiana Costa , Zanin Luciane , Oliveira Arlete Maria Gomes , Dutra Emiliane Rodrigues , Silva Filho David Antonio da , Flório Flávia Martão 
Published: September 2022

A alfabetização em saúde representa as habilidades dos indivíduos para obterem acesso, compreenderem e usarem informações para promover uma boa saúde. Em paralelo, a inclusão digital favorece o conhecimento de novas tecnologias e a integração entre comunidades, facilitando o aprendizado e a melhora da qualidade de vida. O objetivo desse estudo foi avaliar se a inclusão digital e fatores sociodemográficos favorecem a alfabetização em saúde de idosos. Estudo epidemiológico observacional transversal realizado nas cidades de Campinas-SP e Juiz de Fora-MG, considerando uma amostra probabilística de idosos. Foram aplicados três questionários: sociodemográfico, Health Literacy Scale-14 (HSL-14) e o NIDI (Nível de Inclusão Digital Individual). Após análise exploratória, as associações entre as variáveis e o desfecho, nível de alfabetização, foram analisadas por modelos de regressão logística simples, estimando-se os odds ratio brutos com os respectivos intervalos de 95% de confiança. A idade média da amostra de 291 idosos é de 68,2 anos com 50,5% com escolaridade até o fundamental completo, 72,5% com renda de até dois salários-mínimos, 49,8% com baixo nível de inclusão digital e 47,44% com baixo nível de literacia em saúde. Idosos com menor escolaridade (OR=6,74; IC95%: 2,48-18,32) que moram acompanhados (OR=2,12; IC95%:1,22-3,68), que não possuem celular (OR=2,98; IC95%: 1,66-5,38) e que tem baixo nível de inclusão digital (OR=2,17; IC95%: 1,21-3,88) tem mais chance de apresentar menor nível de alfabetização (p<0,05). Conclui-se que a baixa inclusão digital, menor escolaridade, não possuir celular e morar acompanhado associam-se à menor alfabetização em saúde.