bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic Production and Preliminary PET Imaging of a New Imaging Agent [18F]AlF-FAPT
Authors: Huang JiaWen , Fu LiLan , Hu KongZhen , Huang Shun , Han YanJiang , Lin Run , Xu WanBang , Tang Ganghua , Huang Yonghui 
Published: January 2022

BackgroundFibroblast activating protein (FAP) has become an important target for cancer diagnostic imaging and targeted radiotherapy. In particular, [18F]FAPI-42 has been successfully applied to positron emission tomography (PET) imaging of various tumors. However, it exhibits high hepatobiliary metabolism and is thus not conducive to abdominal tumor imaging. This study reports a novel 18F-labeled FAP inhibitor, [18F]AlF-FAPT, a better FAPI imaging agent than [18F]FAPI-42.Materials and MethodsThe precursor of [18F]AlF-FAPT (NOTA-FAPT) was designed and synthesized using the standard FMOC solid phase synthesis method. [18F]AlF-FAPT was subsequently synthesized and radiolabeled with 18F using the AllInOne synthesis module. Dynamic MicroPET and biodistribution studies of [18F]AlF-FAPT were then conducted in xenograft tumor mouse models to determine its suitability.ResultsThe precursors NOTA-FAPT were obtained with a chemical purity of &gt; 95%. [18F]AlF-FAPT was synthesized automatically using the cassette-based module AllInOne within 40 min. The non-decay corrected radiochemical yield was 25.0 ± 5.3% (n=3). In vivo imaging and biodistribution studies further demonstrated that compared with [18F]-FAPI-42, [18F]AlF-FAPT had a lower hepatobiliary uptake than [18F]FAPI-42, which was advantageous for imaging abdominal tumors.Conclusion[18F]AlF-FAPT can be synthesized automatically using a one-step method of aluminum fluoride. Collectively, [18F]AlF-FAPT is a better FAPI imaging agent than [18F]FAPI-42. This study proves the feasibility of using [18F]AlF-FAPT as a new radioactive tracer for PET imaging.
Effects of Neoadjuvant Chemotherapy in Ovarian Cancer Patients With Different Germline BRCA1/2 Mutational Status: A Retrospective Cohort Study
Authors: Fu Mengdi , Jin Chengjuan , Feng Shuai , Jia Zongyang , Nie Lekai , Zhang Yang , Peng Jin , Wang Xia , Bu Hualei , Kong Beihua 
Published: January 2022

BackgroundWhether neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS) against primary debulking surgery (PDS) has a differential effect on prognosis due to Breast Cancer Susceptibility Genes (BRCA)1/2 mutations has not been confirmed by current studies.MethodsAll patients included in this retrospective study were admitted to Qilu Hospital of Shandong University between January 2009 and June 2020, and germline BRCA1/2 mutation were tested. Patients in stage IIIB, IIIC, and IV, re-staged by International Federation of Gynecology and Obstetrics (FIGO) 2014, were selected for analysis. All patients with NAC received 1-5 cycles of platinum-containing (carboplatin, cisplatin, or nedaplatin) chemotherapy. Patients who received maintenance therapy after chemotherapy were not eligible for this study. All relevant medical records were collected.ResultsA total of 322 patients were enrolled, including 112 patients with BRCA1/2 mutations (BRCAmut), and 210 patients with BRCA1/2 wild-type (BRCAwt). In the two groups, 40 BRCAmut patients (35.7%) and 69 BRCAwt patients (32.9%) received NAC. The progression-free survival (PFS) of BRCAmut patients was significantly reduced after NAC (median: 14.9 vs. 18.5 months; p=0.023); however, there was no difference in overall survival (OS) (median: 75.1 vs. 72.8 months; p=0.798). Whether BRCAwt patients received NAC had no significant effect on PFS (median: 13.5 vs. 16.0 months; p=0.780) or OS (median: 54.0 vs. 56.4 months; p=0.323). Multivariate analyses in BRCAmut patients showed that the predictors of prolonged PFS were PDS (p=0.001), the absence of residual lesions (p=0.012), and FIGO III stage (p=0.020); Besides, PARP inhibitor was the independent predictor for prolonged OS in BRCAmut patients (p=0.000), for BRCAwt patients, the absence of residual lesions (p=0.041) and history of PARP inhibitors (p=0.000) were beneficial factors for OS prolongation.ConclusionsFor ovarian cancer patients with FIGO IIIB, IIIC, and IV, NAC-IDS did not adversely affect survival outcomes due to different BRCA1/2 germline mutational status.
Stress, Coping, and Psychiatric Symptoms in Pregnant Women in Outpatient Care During the 2021 Second-Wave COVID-19 Pandemic
Authors: Penengo Chiara , Colli Chiara , Cesco Maddalena , Croccia Veronica , Degano Matilde , Ferreghini Alessandra , Garzitto Marco , Lobel Marci , Preis Heidi , Sala Alessia , Driul Lorenza , Balestrieri Matteo 
Published: January 2022

Aims: Women face many sources of stress throughout their lives, and some periods are particularly sensitive; pregnancy is one of them. The COVID-19 pandemic is a likely source of additional stress for pregnant women. Moreover, there is evidence that pregnant women have experienced high levels of anxiety and depression symptoms during the pandemic. Our study aimed to evaluate the association of pregnancy-specific stress, pandemic-related stress, and coping strategies with anxiety, depressive and obsessive-compulsive symptomatology in Italian women during the second wave of the COVID-19 pandemic (December 2020–June 2021). We also investigated whether there were differences in these levels of psychopathology compared to a prior study conducted during the first pandemic wave (April–August 2020) in Italian pregnant women.Methods: We assessed 325 pregnant women receiving outpatient prenatal care, using the Revised Prenatal Distress Questionnaire (NuPDQ), Pandemic-Related Pregnancy Stress Scale (PREPS), the Revised Prenatal Coping Inventory (NuPCI), General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-2 (PHQ-2), and Obsessive-Compulsive Disorder (OCD) screening. The main analysis was conducted comparing multiple logistic regression models predicting each psychopathological outcome from specific covariates and NuPDQ, PREPS, and NuPCI scores.Results: 42.8% of the sample reported significant levels of anxiety, while 10.3% was positive on depression screening and 13.1% on OCD screening. No significant difference was found in the prevalence of high anxiety, depression, or OCD screening scores compared with the first pandemic wave. Controlling for covariates, we found that GAD-7 and PHQ-2 scores were predicted by pregnancy-specific stress; positive OCD screening was not. The model of high anxiety was improved by adding pandemic-related stress as a predictor (in particular, feeling unprepared for delivery and postpartum). Finally, coping strategies (avoidance, spiritual coping, and planning-preparation) significantly improved prediction of all three psychopathological outcomes.Conclusions: The present study suggests the importance of pregnancy-related stress, COVID-19 pandemic stress, and of coping strategies in counteracting or contributing to psychiatric symptomatology during the current pandemic.
The Impact of Study-at-Home During the COVID-19 Pandemic on Myopia Progression in Chinese Children
Authors: Ma Dandan , Wei Shifei , Li Shi-Ming , Yang Xiaohui , Cao Kai , Hu Jianping , Peng Xiaoxia , Yan Ruohua , Fu Jing , Grzybowski Andrzej , Jin Zi-Bing , Wang Ningli 
Published: January 2022

Background: To assess the impact of study-at-home during the COVID-19 pandemic on myopia development in Chinese schoolchildren.Methods: This historical cohort involved two groups with a total of 154 children. The exposed group was formed from 77 children aged 8 to 10 years who studied at home in the 7-month period during the COVID-19 pandemic (follow-up period: January – August 2020) and did not study at home in the 7-month period before the COVID-19 outbreak (baseline period: July 2019 – January 2020). Seventy-seven children who did not undergo study-at-home (baseline period: 7 months in 2015, follow-up period: 7 months in 2016) were included in the control group. Cycloplegic refraction, axial length and uncorrected visual acuity were measured 3 times. The questionnaire mainly focused on collecting visual habits.Results: Myopia progression was similar between the two groups in the baseline period. However, in the follow-up period the exposed group had a greater change in refraction toward myopia (−0.83 ± 0.56 D) than the control group (−0.28 ± 0.54 D; p &lt; 0.001). In addition, the exposed group exhibited a significantly greater change in refraction toward myopia in the follow-up period (−0.83 ± 0.56 D) than in the baseline period (−0.33 ± 0.46 D; p &lt; 0.001). Difference-in-difference analysis indicated that study-at-home accelerated the change in refraction toward myopia (t = −0.567; p &lt; 0.001).Conclusions: During the COVID-19 pandemic study-at-home accelerated the change of refraction toward myopia in children.
Mengisahkan Ziarah Eksodus Melalui Eskterior Bangunan Gereja
Authors: Rachman Rasid 
Published: January 2022

The exterior of Church building is the clearest face of the community of its members because it is openly showed by anybody. It is not only evidence of the very art and historical heritage but also a content of theological narrative and re-narrative of Church role in the world. This writing will show that there is a theological narrative behind the Church building. In this writing, that theological narrative is limited to the story of the journey and the sojourn of the Israel people in the wilderness to the promised land. From the exodus narrative, I renarrate the role of the Church in the context where it lives. This writing used the theory of bottom with three elements, namely: concept, category, and proposition. The early concept is the exodus narrative according to the Bible. Catching the category, this exodus concept will be anriched by the blended with the narrative of some Church buildings in Indonesia, theology of the Old Testament and liturgy, the anthropology of culture, and the philosophy of architecture. The result of this research is renarrative of the living Church buildings. The proposition is an offer on an interrelation between Biblical narrative, a historical roll of the Church building, and the renarrative or the storytelling renewal, with the present of Church mission. Eksterior bangunan gereja adalah wajah paling jelas persekutuan anggotanya, sebab terlihat secara terbuka oleh siapa pun. Ia bukan hanya bukti mahakarya seni arsitektur dan peninggalan sejarah, tetapi juga berisi narasi teologis dan merenarasikan peran gereja di dunia. Tulisan ini ingin memperlihatkan bahwa ada narasi teologi di balik eksterior bangunan gereja. Dalam tulisan ini, narasi teologi tersebut dibatasi pada kisah perjalanan dan persinggahan umat Israel di padang gurun menuju tanah perjanjian. Dari narasi eksodus tersebut, saya merenarasikan peran gereja di dalam konteksnya.Tulisan ini menggunakan teori dari bawah dengan tiga unsur, yaitu: konsep, kategori, dan proposisi. Konsep awal adalah narasi eksodus sebagaimana kesaksian Alkitab. Untuk mencapai kategori, konsep eksodus ini akan diperkaya dengan memadukan narasi beberapa bangunan gereja di Indonesia, teologi Perjanjian Lama dan liturgi, antropologi budaya, dan filsafat arsitektur. Hasil penelitian adalah renarasi bangunan gereja yang hidup. Proposisi berupa tawaran akan hubungan-hubungan antara narasi Alkitab, guliran historis bangunan gereja berdiri, dan renarasi atau pembaruan penceritaan, dengan misi gereja kini.
Dilema Kepemimpinan Kristen, Tuhan atau atasan?
Authors: Sanderan Rannu 
Published: January 2022

This paper aims to examine and describe the nature of dedicated Christian leadership and to explore the essential elements of servanthood leadership. To serve is one of the most basic substances of Jesus' work. The problem of Christian leadership today is when leaders lose the character of Christ and are trapped in manipulating the name of Christianity or the church for the sake of his/her power. Methodically, this research refers to the leadership patterns of figures in the Old and New Testaments, with the support of literature studies that discuss Christian leadership discourse.
Jesus displaying his leadership as a critique towards the misgovern leader who can only tells order, same as the authoritarian leadership, those who reigning over the official or government employee by own wish or merely by his/her desire. If so, it means that the leader's character humiliates even corrupts his/her own leadership. In all conscience, the leader is a minister to his/her follower's needs; to serve with love, humility, and forgiveness. The result of this study emphasizes that Christian leaders who want to grow up should simply be like Jesus, great leaders originally ought to serve others first, thus in plain reality, the core of his/her leadership will be visible in greatness.

Tulisan ini hendak mengkaji dan menguraikan hakikat kepemimpinan Kristen yang mengabdi, dan mencari tahu unsur esensial dari kepemimpinan yang mengabdi. Mengabdi/melayani adalah sebuah unsur yang sangat mendasar dalam kepemimpinan Yesus. Problem kepemimpinan Kristen masa kini adalah ketika pemimpin kehilangan karakter Kristus, dan justru terjebak mengatasnamakan kekristenan dan gereja untuk kepentingan kekuasaan. Secara metodik, penelitian ini merujuk pola kepemimpinan tokoh dalam Perjanjian Lama dan Perjanjian Baru, dengan dukungan studi kepustakaan yang membahas wacana kepemimpinan Kristen. Yesus memberikan kritik pada kepemimpinan yang bersifat memerintah pengikut, menempatkan pimpinan sebagai bos yang harus selalu diikuti perkataan dan kehendaknya dan tidak memberikan teladan benar. Karakter pemimpin yang demikian merusak dan merendahkan wibawa eksistensi dari kepemimpinan. Seorang pemimpin adalah pelayan bagi pengikutnya. Melayani dgn kasih dan pengampunan. Hasil pengkajian ini menandaskan bahwa seharusnya pemimpin Kristen yang mau besar, mula-mula harus melayani orang lain, dan bahwa kenyataan yg sederhana ini merupakan inti kebesaran-Nya sebagai seorang pemimpin
Analisis Pengaruh Pendidikan Keluarga dan Lingkungan Sosial Terbentuknya Identitas LGBT
Authors: Barutu Parsaoran , Hendriks Alvyn Cesarianto , Hutagalung Stimson , Ferinia Rolyana 
Published: January 2022

Fenomena jumlah LGBT di kota Batam sangat mencengangkan. LGBT adalah sebuah penyimpangan sexual yang dapat merusak generasi remaja dan merusak Gereja sebagai tubuh Kristus. Perlu pencegahan yang serius secara terpadu sehingga fenomena ini dapat ditekan. Oleh sebab itu penelitian ini bertujuan ialah menemukan dan mengkaji pendidikan keluarga dan lingkungan sosial yang berperan untuk mencegah maraknya orientasi seks LGBT ditengah masyarakat sosial serta menghubungkannya dengan dasar Alkitab dari 1 Korintus 15:33: Janganlah kamu sesat: Pergaulan yang buruk merusakkan kebiasaan yang baik. Penelitian ini menggunakan metode kualiatif yang sifatnya deskriptif dengan melakukan wawancara mendalam dari ahli yang ditentukan sebagai informan dengan menggunakan pendekatan studi pustaka dan Alkitab. Hasil dari penelitian ini menunjukan bahwa orientasi seks LGBT disebabkan kurangnya dijalankannya fungsi pendidikan keluarga dan pengaruh lingkungan sosial yang tidak baik.
Pendidikan Keluarga, Lingkungan sosial, LGBT, 1 Korintus 15:33
Faktor-faktor yang Mempengaruhi Perilaku Merokok Pada Remaja Putera Kelas XI di SMK Sasabila Kota Jambi
Authors: Liza  , Fitri Aulia  , Erika  
Published: January 2022

Dalam setiap kepulan asap rokok terkandung ± 4000 racun kimia berbahaya dan 43 diantaranya bersifat karsinogenik (merangsang tumbuhnya kanker). Penelitian di Amerika Serikat yang melibatkan 6813 pria, menunjukkan hasil bahwa 50% perokok berat meninggal pada usia 47,5 th dan 50% perokok sedang meninggal pada usia 56 tahun.. Adapun tujuan penelitian ini adalah Untuk Mengetahui ada nya hubungan antara perilaku merokok dengan pengaruh orangtua, pengaruh teman dan faktor iklan. Dan desain penelitian yang digunakan adalah survey analitik dengan pendekatan Cross Sectional. Pengambilan sampel di lakukan secara Total Sampling yaitu seluruh populasi dijadikan sampel. Analisa data secara univariat dilakukan untuk mengetahui distribusi frekuensi dan persentase dari variabel perilaku merokok pada remaja putera, pengaruh orangtua, pengaruh teman dan faktor iklan, sedangkan analisis data secara bivariat ini dilakukan untuk mengetahui hubungan antara variabel independen dan variabel dependen di analisis dengan uji statistikChi-Squer dimana α =0,05 dan dengan batas kemaknaan bila p value ≤ 0,05 artinya ada hubungan yang bermakna dan bila p value > 0,05 tidak bermakna. Dari hasil univariat menunjukan responden merokok 12 responden (34,4%) dan tidak merokok 23 responden (65,7%), pengaruh orangtua yang baik 21 responden (60,0%) dan tidak baik 14 responden (40,0%), pengaruh teman yang baik 16 responden (45,7%) dan yang tidak baik 19 responden (54,3%), responden merokok karena faktor iklan 11 responden (31,4%) dan tidak 24 responden (68,6%), dan hasil bivariat menunjukan pengaruh orangtua baik yaitu 3 responden (13,6%) tidak yaitu 9 responden (69,2%), pengaruh teman baik yaitu 10 responden (62,5%) dan tidak yaitu 2 responden (10,5%), faktor iklan yang ya yaitu 8 responden (72,7%) dan tidak yaitu 4 responden (16,7%). Orangtua harus lebih memperhatikan perkembangan anak, terutama remaja putera terhadap kejadian perilaku merokok pada remaja putera yang semakin memarak terutama dikalangan anak sekolah pertama (SMK).
Penanganan Efek Samping Kontrasepsi Suntik 3 Bulan Pada Akseptor KB Suntik
Authors: Yuhemy Zurizah  , Juni  , Lara Arah Dea  
Published: January 2022

Berdasarkan data Badan Pusat Statistik (BPS) jumlah penduduk Indonesia adalah sebesar 219,2 juta jiwa, dengan rata-rata laju pertumbuhan penduduk sekitar 1,8 persen pertahun. Salah satu cara untuk menekan laju pertumbuhan penduduk adalah melalui program keluarga berencana yaitu menurunkan tingkat kelahiran. Tujuan penelitian ini adalah bagaimana penanganan efek samping kontrasepsi suntik 3 bulan pada akseptor KB Suntik. Desain penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan fenomenologi. Penelitian kualitatif merupakan suatu penelitian yang bersifat eksploratif terhadap suatu gejala atau fenomena yang memberikan gambaranformatif dari keadaan yang menjadi faktor kausatif fenomena tersebut. Fokus penelitian ini didasarkan pada penemuan fakta suatu fenomena berdasarkan perspektif informan. Informan diseleksi menggunakan teknik sampling purposive yaitu informan yang mempunyai karakteristik sesuai dengan tujuan penelitian. Kesimpulan dalam penelitian ini adalah Pada pengetahuan ibu didapatkan 2 tema yaitu tema 1 tentang tujuan ibu dalam penggunaan KB suntik dan tema 2 tentang konsep dasar KB suntik 3 bulan. Informan mengatakan bahwa tujuan penggunaan KB suntik yaitu untuk mencegah kehamilan dan dua dari keempat informan mengatakan bahwa kb suntik dapat mengatur jarak kehamilan. Pada kategori 1 tema 2, keempat informan mengatakan bahwa lokasi penyuntikan yaitu di bokong. Kemudian untuk kategori 2 informan mengatakan keuntungan kb suntik 3 bulan yaitu dapat mencegah kehamilan dalam waktu yang cukup lama, aman digunakan untuk ibu yang sedang menyusui, dan efektif.Pada efek samping kb suntik 3 bulan yang dialami ibu primipara didapatkan 1 tema yaitu tema 3 tentang efek samping yang dialami ibu primipara. Informan mengalami sakit kepala sejak menggunakan kb suntik 3 bulan dan keluar bercak darah sedikit-sedikit, telat mensturasi, dan tidak mengalami mensturasi selam 2 bulan setelah disuntik. Pada tindakan yang dilakukan dalam penanganan efek samping kontrasepsi suntik 3 bulan oleh ibu primipara didapatkan 1 tema yaitu tema 4 tentang penanganan efek samping kb suntik 3bulan. Informan mengatakan bahwa tindakan yang mereka lakukan untuk mengatasi efek samping kb suntik 3 bulan yaitu tiduran atau istirahat dan minum bodrek untuk mengatasi sakit kepala, dan informan mengatakan kalau mereka pernah mengganti dengan kb pil karena tidak tahan mengalami efek samping tersebut
Pemanfaatan Instagram sebagai Media Komunikasi Pemasaran dalam Membangun Brand Image
Authors: Wainira Maria A.D. , Liliweri Yohanes K.N. , Mandaru Silvania S.E. 
Published: January 2022

Maraknya penggunaan media sosial khususunya Instagram sekarang ini, membuat banyak pelaku bisnis di luar sana yang memanfaatkan dan menggunakan Instagram untuk memasarkan produk/brand mereka. Begitupula yang dilakukan oleh Kopi Papa Ganteng. Sebagai sebuah bisnis minuman kopi lokal, brand image yang positif dan kuat sangat diperlukan dan sangat penting bagi Kopi Papa Ganteng karena dapat menjadi hal yang memebedakannya dengan para pesaing atau brand sejenis lainnya. Penelitian ini sendiri bertujuan untuk mengetahui dan mendeskripsikan komunikasi pemasaran Kopi Papa Ganteng dalam membangun brand image melalui pemanfaatan media sosial Instagram. Teori yang digunakan dalam penelitian ini adalah marketing mix theory yang di dalamnya terdapat 4 konsep yaitu product, price, place, dan promotion. Penelitian ini menggunakan metode deskriptif kualitatif, dengan Subjek penelitiannya yaitu akun Instagram @kopipapaganteng dan Pemilik dari Kopi Papa Ganteng. Dimana data penelitian dikumpulkan melalui teknik wawancara, observasi dan juga dokumentasi. Hasil penelitian menunjukan bahwa kegiatan komunikasi pemasaran Kopi Papa Ganteng dalam membangun brang iamge melalui Instagram melibatkan semua elemen bauran pemasaran atau marketing mix yakni product, price, place, dan promotion. Dimana konsep produk, harga, tempat, dan kegiatan promosi yang dilakukan, dapat memberikan citra yang baik bagi Kopi Papa Ganteng. Kemudian dalam melakukan komunikasi pemasaran, Kopi Papa Ganteng memanfaatkan dengan baik fitur-fitur yang ada di Instagram, seperti fitur Instagram story, fitur highlights, fitur unggahan foto atau video, fitur caption dan hastag.
Numerical analysis of wave propagating in a periodic layered structure
Authors: Fukuchi Takaaki , Mori Naoki , Hayashi Takahiro 
Published: January 2022

Abstract
Controlling sound fields is a key technology for noise removal, acoustic lenses, energy harvesting, etc. This study investigated the control of sound field by a periodic layered structure. At first, we formulated the wave propagation in a periodic layered structure and proved that the wave fields constructed by the periodic boundary conditions are limited to plane wave modes with discretely different propagation directions. Numerical calculations clarified that the desired plane wave mode can be obtained in the transmitted wave through an intermediate thin-plate stacked region in a periodic layered structure, in which Lamb waves travel in each plate at different phase velocities and create phase difference at the exit of the intermediate thin-plate region. Further numerical investigations revealed that tuning frequency and the length of the thin-plate region provides wave field more dominantly with a single wanted plane wave mode.
Room temperature fabrication and post-annealing treatment of amorphous Ga2O3 photodetectors for deep-ultraviolet light detection
Authors: Zhang Tan , Guan Denggao , Liu Ningtao , Zhang Jianguo , Zhang Jinfu , Guo Chenyu , Qiu Mengting , Yuan Qilong , Zhang Wenrui , Ye Jichun 
Published: January 2022

Abstract
This work fabricates deep-ultraviolet (DUV) photodetectors (PDs) with a metal-semiconductor-metal structure based on radio-frequency sputtered amorphous Ga2O3 films at room temperature. The Ga2O3-based PD exhibits a low dark current of 1.41 × 10−11 A, a responsivity of 1.77 A W−1 and a fast rise response time of 114 ms. A series of annealing treatments with different atmospheres have been found effective to reduce the oxygen vacancy concentration, exhibiting a trade-off effect between the responsivity and the response time. These results demonstrate a cost-effective room-temperature approach for fabricating amorphous Ga2O3-based PDs and developing possible post-synthetic methods for tuning the PD performance.