bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latent Subtypes of Childhood Psychological Maltreatment and their Links to Adult Mental Health in China and the UK
Authors: Xiao Zhuoni , Obsuth Ingrid , Meinck Franziska , Murray Aja 
Published: September 2022

Abstract
Background
Though links between childhood maltreatment and mental health have been established, little known about how specific types of childhood maltreatment tend to cluster and how the resulting patterns of exposure impact mental health outcomes.
Method
The current study used latent profile analyses in Chinese (N = 544) and UK (N = 589) samples to identify childhood psychological maltreatment profiles (i.e., profiles of psychological abuse, psychological neglect, and psychological non-support) in different country contexts, and their associations with a range of mental health (i.e., depression, anxiety, anger, physical aggression, verbal aggression, and hostility), and broader well-being (i.e., self-esteem) outcomes.
Results
Four profiles were identified in both samples, but their nature differed between the Chinese sample (“Psychological Non-support”, “Low-Maltreated”, “High-Maltreated”, and “Severe-Maltreated”) and the UK sample (“Low-Maltreated”, “Moderate-Maltreated”, “High-Maltreated”, and “Severe-Maltreated”). Individuals in the “Psychological Non-support” in China and “Low-Maltreated” class in the UK displayed better mental health outcomes – lower levels of depression, anxiety, and aggression, and higher self-esteem. In contrast, individuals in the “Sever-Maltreated” profiles in both the Chinese and UK samples displayed poorer mental health outcomes – higher depression, anxiety, and aggression, and lower self-esteem. Interventions and prevention efforts are needed for individuals categorized in the “Sever-Maltreated” profile.
Conclusion
Further research is needed to illuminate contextual differences in psychological maltreatment profiles and their links to mental health.
Bringing Antarctica to the lab: A polar desert environmental chamber to study the response of Antarctic microbial communities to climate change
Authors: Monteiro Maria R. , Marshall Alexis J. , Lee Charles K. , McDonald Ian R. , Cary Stephen C. 
Published: September 2022

Abstract
Polar deserts contain unique and sensitive communities responsive to climate-associated habitat changes. However, unlike temperate desert ecosystems, characterizing and predicting the responses of polar ecosystems to environmental change remains a significant challenge due to logistical constraints. Here we aim to demonstrate the use of a custom-designed Polar Desert Environmental Chamber (PDEC) to perform off-continent experimental ecological research. We did so by characterizing the structure and composition of arid edaphic bacterial communities collected from the McMurdo Dry Valleys during a simulated wetting event. The results were discussed in light of previous field observations. Rapid structural and compositional changes were observed during wetting and re-drying treatments. Those were driven by changes in the relative abundance of co-existing taxa, which fluctuated asynchronously over time in response to the treatments. While selection was the main ecological factor attributed to the changes observed during the initial wetting, over time, neutral processes began to drive community assembly in communities that remained wet. Ultimately, this observation reflects the presence of microbial taxa with divergent adaptations to water stress, which can be argued as beneficial to increasing resilience in polar deserts. Our findings demonstrate that experiments conducted in PDEC provide valuable contextual data on community response to environmental change and can accelerate our ability to assess biological thresholds to change within polar desert ecosystems. We advocate that, with careful consideration of key emulated environmental attributes, laboratory-based Antarctic research can complement fieldwork to achieve a nuanced and evidence-based understanding of the ecology of Antarctica's ice-free regions.
Analysis for Osteoarthritis of the Ankle Joint in a Mouse Model of Chronic Ankle Instability
Authors: Kim Ju Young , Eun So Young , Kim Do Kyun , Yoo Byung Min , Lee Sung Hyun 
Published: September 2022

Abstract
Background
Ankle sprains are the most common orthopedic pathology experienced during sports and physical activity and often result in chronic ankle instability (CAI). The purpose of this study was to assess osteoarthritic changes in the ankle joint in a surgical CAI mouse model.
Method
The experiments were performed using 14-week-old ICR male mice (n = 19). Mice were randomly placed into the SH group (sham; control, n = 5), ATFL group (resected anterior talofibular ligament; mild ankle sprain, n = 7), or ATFL + CFL group (resected anterior talofibular ligament / calcaneofibular ligament; severe, n = 7) and housed individually. Behavioral analysis using the frequency of standing on the hind leg was performed. To evaluate the clinical severity of arthritis, bodyweight, paw thickness, and ankle thickness were assessed immediately before sacrifice. Immunohistochemical staining and micro-computed tomography were performed to analyze the arthritic changes of the ankle joint. Serological analysis of inflammatory cytokines and C-terminal telopeptide of type I bone resorption markers was performed using enzyme-linked immunosorbent assay (ELISA).
Results
Compared with the control group, the ATFL + CFL group significantly aggravated the clinical severity of arthritis. In the ATFL and ATFL + CFL groups, the number of mice standing on the hind leg was significantly decreased. ELISA confirmed that the inflammatory cytokines were significantly increased in the ATFL + CFL group. C-terminal telopeptide of type I levels were increased in the ATFL + CFL group but the difference was not statistically significant.
Conclusions
This study demonstrated that the surgical induction of chronic ankle instability (ATFL + CFL) in a mouse model results in the development of osteoarthritis of an ankle joint.
Evaluation of circulating renin-angiotensin system components in pediatric patients with acute leukemia: a pilot study
Authors: Pena Ana Luísa Batista , de Castro Pedro Alves Soares Vaz , Severo Renata Gomes , Ribeiro João Paulo Ferreira , Silva Ana Cristina Simões e 
Published: September 2022

Abstract
Introduction: Acute leukemia (AL) is the most common cancer of childhood. In recent years, there has been an important advance in the survival rate of these patients. The objective of this study was to assess whether there is an association between the blood levels of Renin Angiotensin System (RAS) molecules in children with acute AL and disease presentation and evolution in pediatric patients. Materials and Methods: This is a cross-sectional study carried out in a group of pediatric patients with AL. We measured blood levels of Angiotensin II (Ang II) and Angiotensin-(1-7) [Ang-(1-7)] by enzyme immunoassay. The Ang-(1-7)/Ang II ratio was calculated as a parameter of the balance between the alternative and classical axes of the RAS. Results: Eleven patients with AL and 20 healthy controls matched by sex and age were included. Patients with AL had significantly higher levels of both peptides when compared with healthy controls (p < 0.05). However, no significant difference was found in the Ang-(1-7)/Ang II ratio between the two groups. A strong and positive correlation was detected between Ang II and Ang-(1-7) levels in patients with AL (r = 0.853; p < 0.0001). There was no significant difference between the levels of Ang II and Ang-(1-7), as well as the Ang-(1-7)/Ang II ratio, the type of AL and clinical outcomes. Conclusion: Both Ang-(1-7) and Ang II seem to be involved in the physiopathology of AL and other molecules of the RAS could be potentially explored for the development of new therapeutic options for AL.
Total neoadjuvant treatment (consolidation chemotherapy) provides highest rate of clinical complete response for rectal cancer: analysis of 5-year long-term oncological outcomes with watch and wait protocol
Authors: Asoglu Oktar , Bulut Alisina , Aliyev Vusal , Piozzi Guglielmo Niccolò , Guven Koray , Bakır Barıs , Goksel Suha 
Published: September 2022

Abstract
Aim

To reveal whether chemoradiotherapy-consolidation chemotherapy (CRT-CNCT) treatment provides more organ preservation in locally advanced rectal cancer (LARC) and its effect on oncological outcomes.

Method

Retrospective analysis of prospectively maintained database was performed. Oncological outcomes of mid-low LARC patients (n = 60) were analyzed after a follow-up of 63 (50–83) months. Patients with clinical complete response (cCR) were treated with the watch-and-wait (WW) protocol. Patients who could not achieve cCR were treated with total mesorectal excision (TME) or local excision (LE).

Results

Thirty-nine (65%) patients who achieved cCR were treated with the WW protocol. TME was performed in 15 (25%) patients and LE was performed in 6 (10%) patients. During the follow-up period, 10 (25.6%) patients in the WW group had regrowth (RG) and 3 (7.6%) had distant metastasis (DM). 5-year overall survival (OS) and disease-free survival (DFS) were 90.1% and 71.6%, respectively, in WW group. 5-y OS and DFS were 94.9% (95% CI: 88–100%) and 80% (95% CI: 55.2–100%), respectively, in the RG group. 5-y OS and DFS were 90.1% (95% CI: 78.9–100%) and 96.6% (95% CI: 89.9–100%) in the non-RG group. 5-y OS and DFS were 78% (95% CI: 55.8–100%) and 60% (95% CI: 35.2–84.8%) in TME group.

Conclusion

CRT-CNCT provides cCR as high as 2/3 of LARC patients. While the WW protocol provides organ preservation, RGs developed during follow-up can be successfully salvaged without causing oncological disadvantage.
Is YouTube a reliable tool for approaching Robotic-assisted Transabdominal Preperitoneal (RTAPP) surgery? a critical review of the available resources
Authors: Sanchez Alexis , Rodriguez Omaira , Medina Manuel , Vegas Liumariel , Couto Francisco , Mogollon Ivan , Inchausti Cristina 
Published: September 2022

Abstract
Inguinal hernia is one of the most common surgical conditions, with an incidence of 27 to 43% in men and 3 to 6% in women. Surgical repair of inguinal hernia must adhere to the 10 golden rules to achieve optimal results. Robotic assisted transabdominal preperitoneal (RTAPP) is a relatively new technique for the management of this pathology. Trainee surgeons often review surgical videos to familiarize themselves with new techniques. The most reviewed video platform by surgeons in training is YouTube, 86 to 92% of trainee surgeons have used this platform to become acquainted with new surgical techniques. Due to the lack of peer review or medical verification, YouTube videos may represent an unreliable source of educational material The objective of this study is to perform a thorough critical analysis of the 10 most viewed Robotic assisted transabdominal preperitoneal (RTAPP) related videos on YouTube to determine their compliance with the ten golden rules.
Determining the Incidence of Heart Malformations in Neonates: A Novel Clinically Approved Solution
Authors: Bordbar Arash , Kashaki Mandana , Vafapour Maryam , Sepehri Amir A. 
Published: September 2022

Abstract
Background: Screening for critical congenital heart defects should be done as early as possible and is essential to save lives and reduce the incidence of undetected adult congenital heart diseases. Over 50% of neonates with heart malformations remain unrecognized at birth. Accurate screening for congenital heart malformations is achievable using a certified and internationally patented digital intelligent phonocardiography machine. This study aimed to assess the actual incidence of newborn heart defects in a well-baby nursery and evaluate digital intelligent phonocardiogram screening for critical congenital heart defects.
Methods: We conducted the “Neonates Cardiac Monitoring Research Project” (ethics approval number: IR-IUMS-FMD. REC.1398.098) at the Shahid Akbarabadi Maternity Hospital. This study is a retrospective analysis of screening congenital heart malformation in 840 neonates. Randomly, 840 neonates from the well-baby nursery underwent standard clinical examinations at birth and digital intelligent phonocardiogram examination in a double-blinded format. Pediatric cardiologist performed echocardiography for each neonate classified as abnormal using the intelligent machine or routine medical examinations. If a follow up was demanded by the pediatric cardiologist, the neonate was considered as having a congenital heart malformation and the cumulative incidence proportion was calculated accordingly.
Results: The incidence of heart malformations in the well-baby nursery was 5%, and 44% of neonates with heart malformations were unrecognized at birth based on the standard medical examination results, including those with critical congenital heart defects (CCHD). An intelligent phonocardiogram recognized 100% of neonates with heart malformations.
Conclusion: We accurately and cost-effectively screened for congenital heart malformations in all neonates in our hospital using a digital intelligent phonocardiogram. We detected neonates with CCHD and congenital heart defects using an intelligent machine; these could not be detected using standard medical examinations. In addition, the intelligent machine interpreted innocent murmurs as healthy heart sounds.
Van With Public Works, Economic And Social Developments (1923-1960)
Authors: KARDAŞ Abdulaziz 
Published: September 2022

Van, sahip olduğu coğrafi özellikler ve askeri-stratejik konumu nedeniyle tarih boyunca birçok medeniyetin dikkatini çekmiştir. Osmanlı Devleti’nin son döneminde de önemini koruyan Van, I. Dünya Savaşı yıllarında çıkan Ermeni İsyanları ve ardında gerçekleşen Rus işgali şehrin tahrip olmasına yol açmıştır. Savaş sonrasında muhaceretten dönenler ve evleri tahrîp olanlar eski şehirde barınacak bir yer bulamadıkları için gölden 7-8 km uzaklıkta daha az tahrip edilmiş olan bağ ve bahçelik alanlara yerleşmek suretiyle yeni Van şehrini meydana getirmişlerdi.
Van, Cumhuriyetin ilanı ile birlikte yeni devletin vilâyetleri arasında yer almıştı. Bu dönemde yeni devletin kuruluş felsefesi çerçevesinde vilayetlerin bayındırlık, iktisadi, sosyal, kültürel gibi alanlardaki sorunları giderilmeye çalışılmıştır. Bu bağlamda I. Dünya Savaşı yıllarında yakılıp yıkılan Van’ın yeniden kalkındırılması için çalışmalara başlanmıştır. Vilâyetin en temel sorunları arasında yer alan ulaşım ve taşımacılık alanında yeni adımlar atılmıştır. Karayolu ve köprü alanında çalışmalar yapılmış, bunun yanında ulaşım ve taşımacılıkta önemli rol oynayan Van Gölü İşletme İdaresi’nin çalışmaları planlı hale getirilmeye çalışılmıştır. Bunların yanında demiryolunun Van’a ulaştırılması ve hava ulaşımı için havaalanın açılması ve seferlerin planlanmasına gayret edilmiştir. Ulaşım ve taşımacılığın yanında şehrin tarım alanında gelişmesini sağlamak amacıyla sulama kanalları yapılmıştır. Şehrin içme suyu sorunu çözmek amacıyla yeni çalışmalar yapılmıştır. Bu dönemde ayrıca şehrin aydınlatılması ve sanayinin gelişmesinde önemli rol oynayacak elektrik santrallerinin yapılmasına başlanmıştır.
Söz konusu çalışmaların yanında Van’da kalkınmayı sağlayacak nüfusun artırılması için göç-iskân politikası uygulanmıştır. Van’a gelen göçmenler İskele Köyü ve Edremit civarında iskân edilmiştir. Hükümet, Van mimarisine de örnek olabilecek devlet daireleri ve göçmen evleri inşa etmiştir. Ancak dönem içerisinde meydana gelen depremlerin yol açtığı yıkım, devletin bayındırlık alanındaki faaliyetlerini yok etmiştir.
Van’ın eğitim ve kültür alanlarında gelişmesini sağlamak amacıyla ilköğretimde yeni okullar açıldı. Orta ve yükseköğretimde de sanat okulları, Ernis Köy Enstitüsü ve Doğu Üniversitesi gibi kurumların açılması ve faaliyetlerinin yoğunlaştırılmasına çalışılmıştır. Van’da sağlık sorunlarının çözülmesi amacıyla yeni kurumlar açılmış ve bu dönemde yaşanan salgın hastalıklarla mücadele edilmiştir.
Biosafety pada Laboratorium Biologi Sekolah Menengah Atas Se-Kota Yogyakarta
Authors: Sari Maulida Ivana , Nisa Rifda Khairun , Messy Messy , Rahmawati Senja Amalia , Saifuddin Moch. Fuad , Puspitasari Etika Dyah 
Published: September 2022

Laboratorium biologi memiliki potensi besar menyebabkan kontaminasi atau menyebarkan penyakit, termasuk pada level laboratorium biologi SMA. Oleh karena itu, biosafety perlu dipastikan terimplementasi guna mengurangi risiko paparan agen yang menyebarkan penyakit. Penelitian ini untuk mengetahui penerapan Biosafety di Laboratorium Biologi SMA di kota Yogyakarta. Pengambilan sampel sekolah secara random dari sekolah yang ada di kota Yogyakarta. Pengambilan data melalui wawancara secara langsung terhadap laboran atau guru biologi sekolah A, B, dan C. Data dianalisis secara deskriptif kualitatif. Hasil analisis menunjukkan sekolah A, B, dan C telah menerapkan Biosafety saat praktikum di laboratorium biologi. Hanya saja ada beberapa hal dari ketiga sekolah tersebut yang harus diperbaiki dan ditingkatkan agar menjadi laboratorium biologi sekolah dengan keamanan yang baik.
An investigation into the use of acid treated sugar cane bagasse ash-based coagulants for water treatment
Authors: Falayi Thabo 
Published: September 2022

Abstract
The aim of the study was to investigate the possibility to use acid treated sugarcane bagasse ash (SCBA) as a coagulant. The effect of type of acid, coagulant dose, time and pH on the coagulation characteristic were investigated. Synthetic turbid water was used for the tests. The coagulants were treated with H2SO4 (SSCBA) and HCl (HSCBA). A 6% m/v solid loading (S/L) of HSCBA reduced turbidity by 97.7% whilst an 8% m/v S/L of SSCBA reduced turbidity by 90.9%. Both coagulants exhibited hindered, transition and compression settling characteristics, however HSCBA had faster settling pattern. Turbidity reduction was best in the 6–10 pH range where there was over 90% turbidity reduction from an initial synthetic turbid water of 110 nephelometric turbidity units (NTU). Both coagulants were tested against natural highly turbid river water, and it was shown that only the HSCBA could reduce turbidity from 1,644 NTU to 2 NTU over 100 min. It was also shown that an overflow rate allowance of 0.01 cm/s could achieve 90% turbidity reduction using HSCBA when type 1 settling used for empirical calculations. The use of HSCBA was also shown to result in an insignificant amount of residual pH, Fe, Cu and Zn in the treated water. This therefore makes the use of HSCBA favorable in that it does not change the chemistry of the treated water.
AI in Health Science: A Perspective
Authors: Mishra Raghav , Chaudhary Kajal , Mishra Isha 
Published: September 2022

Abstract:
By helping practitioners understand complicated and varied types of data, Artificial Intelligence (AI) has influenced medical practice deeply. It is the use of a computer to mimic intelligent
behaviour. Many medical professions, particularly those reliant on imaging or surgery, are progressively developing AI. While AI cognitive component outperforms human intellect, it lacks awareness, emotions, intuition, and adaptability. With minimum human participation, AI is quickly growing in healthcare, and numerous AI applications have been created to address current issues. This
article explains AI, its various elements and how to utilize them in healthcare. It also offers practical
suggestions for developing an AI strategy to assist the digital healthcare transition.
Japanese Cedar Pollen Allergens in Japan
Authors: Ohashi-Doi Katsuyo , Utsumi Daichi , Mitobe Yuko , Fujinami Koji 
Published: September 2022

Abstract:
Pollen from members of the Cupressaceae tree family is one of the most important causes of allergic disease in the world. Cryptomeria japonica (Japanese cedar) and Chamaecyparis obtusa (Japanese cypress) are the most common tree species in Japan. The pollen dispersal season is mainly from February to May. The major allergens of Japanese cedar and Japanese cypress exhibit high amino acid sequence similarity due to the phylogenetic relationship between the two species. An epidemiological study has shown that the prevalence of Japanese cedar pollinosis is approximately 40%. In fact, younger children (5 to 9 years old) showed high prevalence of Japanese cedar pollinosis as 30% in 2019, indicating that season pollinosis is getting worse. The most common treatment for pollinosis induced by Japanese cedar and Japanese cypress is pharmacotherapy. Patients’ satisfaction with pharmacotherapy is low due to insufficient experienced effect and daytime somnolence. Unlike pharmacotherapy, allergy immunotherapy (AIT) addresses the basic immunological mechanisms of allergic disease and activates protective allergen-reactive pathways of the immune system. AIT is now recognized as the only treatment option with the potential to provide long-term post-treatment benefit and alter the natural course of the allergic disease including Japanese cedar pollinosis.
TiO2-NPs Toxicity and Safety: An Update of the Findings Published over
the Last Six Years
Authors: Grande Fedora , Tucci Paola , Bevacqua Emilia , Occhiuzzi Maria Antonietta 
Published: September 2022

:
Nanotechnology has greatly impacted our daily life and has certainly yielded many
promising benefits. Titanium dioxide nanoparticles (TiO2-NPs) are among those produced on a
large industrial scale that have found many practical applications in industry and daily life. Due to
their presence in products such as food, cosmetics, sunscreens, medications, paints or textiles,
contact with TiO2-NPs in our daily life is inevitable. The small size, together with the corresponding
large specific surface area, make nanoparticles able to penetrate through cellular barriers and
reach various parts of the body through different routes of exposure, including inhalation, injection,
dermal penetration, and gastrointestinal tract absorption. Furthermore, after long-term exposure,
the TiO2-NPs could accumulate in tissues leading to chronic diseases. This raises serious
doubts about their potentially harmful effects on human health.

:
In the past, TiO2-NPs have been considered inert, however, many in vitro studies have shown that
they were cyto- and genotoxic, leading to the production of reactive oxygen species (ROS) and to
the activation of signaling pathways involved in inflammation and cell death. Several in vivo studies
have also demonstrated that TiO2-NPs, once in the bloodstream, could reach and accumulate in
important organs causing toxic effects. Very recently, the International Agency for Research on
Cancer (IARC) has classified these nanoparticles as possibly carcinogenic to humans.

:
In this survey, we summarize the latest advances in acknowledging the toxicity and safety of
TiO2-NPs. Since the literature is often controversial, further studies are still needed to define the
risk/benefit ratio of using these nanoparticles. Overall, the data herein reported are critical for assessing
human risk after exposure to TiO2-NPs.