bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives of Rare Disease Social Media Group Participants on Engaging With Genetic Counselors: Mixed Methods Study
Authors: Yabumoto Megan , Miller Emily , Rao Anoushka , Tabor Holly K , Ormond Kelly E , Halley Meghan C 
Published: November 2022

Background
Social media provides a potential avenue for genetic counselors to address gaps in access to reliable genetics information for rare disease communities. However, only limited research has examined patient and family attitudes toward engaging with genetic counselors through social media.

Objective
Our study assessed the attitudes of members of rare disease social media groups toward engaging with genetic counselors through social media, characteristics associated with greater interest, and the benefits and potential pitfalls of various approaches to such engagement.

Methods
We conducted a mixed methods survey of patients and family members recruited from a systematic sample of rare disease Facebook groups. Patient characteristics and their associations with interest in engagement with genetic counselors were evaluated using univariate and bivariate statistics. Responses to open-ended questions were analyzed using thematic content analysis.

Results
In total, 1053 individuals from 103 rare disease groups participated. The median overall interest in engaging with genetic counselors on social media was moderately high at 7.0 (IQR 4.0-9.0, range 0-10). No past experience with a genetic counselor was associated with greater interest in engaging with one through social media (µ=6.5 vs 6.0, P=.04). Participants expressed greatest interest (median 9.0, IQR 5.0-10.0) in engagement models allowing direct communication with genetic counselors, which was corroborated by the majority (n=399, 61.3%) of individuals who responded to open-ended questions explicitly stating their interest in 1-on-1 interactions. When asked what forms of support they would request from genetic counselors through social media, participants desired individualized support and information about how to access services. However, participants also expressed concerns regarding privacy and confidentiality.

Conclusions
Patients and family members in rare disease social media groups appear interested in engaging with genetic counselors through social media, particularly for individualized support. This form of engagement on social media is not meant to replace the current structure and content of genetic counseling (GC) services, but genetic counselors could more actively use social media as a communication tool to address gaps in knowledge and awareness about genetics services and gaps in accessible patient information. Although encouraging, concerns regarding privacy and feasibility require further consideration, pointing to the need for professional guidelines in this area.
Assessment of the Impact of Fatigue on the Degree of Dependance in Hemodialysis Patients
Authors: Figueiredo Ana Elizabeth , Domingues de Figueiredo Julia , Santos Bueno Isadora 
Published: November 2022

Background: Patients undergoing hemodialysis (HD) go through a number of physical and emotional symptoms that can interfere with their comfort and quality of life, a common symptom is tiredness, a condition which is conventionally called post dialysis fatigue (PDF). Therefore, the objective is to evaluate the relationship between fatigue and the degree of dependence in performing basic and instrumental activities of daily living on patients undergoing hemodialysis.
Method: Cross-sectional study, carried out at the hemodialysis unit of Hospital São Lucas da Pontificia Universidad Católica do Rio Grande do Sul.. The study reporting adheres to the STROBE checklist.
Results: From the 101 patients interviewed, 63 (62.4%) had post dialysis fatigue, with a mean age of 59±7 years, where the majority were men with 66.3% (n=67). The presence of PDF was related to vintage on HD (p<0,041), session recovery time (p<0,000) and shift of the session (p<0.001). There was no association of PDF with the degree of dependence on basic and instrumental activities of daily living.
Conclusion: More than half of the patients on HD experience PDF, it is less frequent in patients dialyzing in the night shift and it is associated with dialysis vintage and with greater recovery time.
Parkland Diabetes Clinic
Authors: Jafri Farzan , Gunasekaran Uma 
Published: November 2022

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<p>This project was conducted at the Parkland Diabetes Clinic in Dallas, TX, an endocrinology clinic that operates within the Parkland Health System, a safety-net health system that serves the indigent population of Dallas County. The clinic conducts ~1,200 visits per month, including new referrals, follow-up visits, social work services, teleretinal screenings, nursing services, mental health care, and diabetes education visits. The clinic has 16 providers, including several attending physicians (endocrinologists), several endocrinology fellows, physician associates, and nurse practitioners. The clinic is also supported by additional staff, including certified diabetes care and education specialists, a social worker, a clinical pharmacist, a part-time mental health counselor, and a part-time psychiatrist, as well as a nurses, medical assistants, and clerical staff.</p>
<p>The patient population served at the clinic is ethnically diverse (50% Hispanic/Latinos, 30% Black, and 15% non-Hispanic White) and predominantly underserved (50% receive charity care, and 10% have commercial insurance).</p>
Quit Smoking Clinic: Factors Associated with Successful Quit Smoking in Besut District, Terengganu State of Malaysia
Authors: Ismail Nur Raihan , Awang Hafizuddin , A Rahman Nurul Jannah , Ahmad Daud Arfizah , Zulrushdi Mohd Fariz , Zainuddin Azmi , Abd Rahman Mohd Anuar , Embong Kasemani 
Published: November 2022

Background: Malaysian National Health and Morbidity Survey 2019 illustrated the prevalence of current smoker was 21.3%. Out of current smokers, only about half of them made an attempt to quit smoking in the past 12 months and only 7.4% of the smokers had visited a healthcare provider for quit smoking advice. The “Quit Smoking Clinic” was established in Malaysia since 2000 to make smoking cessation service accessible for everyone. This study aims to determine the factors associated with successful quit smoking among smokers attending “Quit Smoking Clinic” in Besut District, Malaysia.
Methods: A district-wide record review study using “Quit Smoking Clinic” record [BPKK/KBM(PKD)/3/2012 Amendment 2018] from seven health clinics was conducted. A logistic regression (LR) model was performed to assess the factors influencing successful quit smoking status. A success quit smoking status was defined as remaining abstinent from smoking behavior at six months of clinic follow-up.
Result: A sample of 414 clients from seven health clinics in Besut were included, 14.3% of them had a success quit smoking status. In the final MLR model, factors influencing successful quit smoking were older age group 45 years old and above (Adj. OR 2.27; 95% CI: 1.22, 4.22, p-value=0.010), voluntary participation in the clinic (Adj. OR 1.86; 95% CI: 1.00, 3.45, p-value=0.049) and frequent visits to the clinic (Adj. OR 5.33; 95% CI: 2.88, 9.86, p-value<0.001).
Conclusion: Recognition of these factors associated with the success of quit smoking status is beneficial to improve the service of “Quit Smoking Clinic” as well as to promote an accessible smoking cessation support for smokers in the district. Reinforcement of tobacco control policies in Malaysia is imperative to encourage more smokers to quit smoking in the country.
Predictors of ICT Use in Teaching in Different Educational Domains
Authors: Zubković Barbara Rončević , Pahljina-Reinić Rosanda , Kolić-Vehovec Svjetlana 
Published: November 2022

AbstractThis study explored the implementation of the information and communication technology (ICT) into teaching and learning processes in three educational domains (STEM, language education, and other humanities and social sciences). Specificaly, the aim of the current study was to explore the effects of teachers' attitudes towards ICT use in classroom, self-efficacy in the ICT use, and perceived school-level barriers on teachers' ICT use as well as possible domain specific differences in the assessed variables. The data were collected as a part of a larger study conducted within the first phase of the “e-Schools” pilot project (CARNet). An online survey methodology was employed involving a sample of nearly all teachers in 13 middle (N=256) and 7 high schools (N=275). The results revealed that perceived self-efficacy in ICT use proved to be the best predictor of the use of ICT based activities regardless of the domain. Perceived benefits of ICT use significantly predicted the use of ICT in STEM and humanities and social sciences, while school-level barriers negatively predicted ICT use in STEM and in language education. Comparison of educational domains showed that STEM teachers saw more benefits of ICT use in teaching than teachers in humanities and social sciences. STEM teachers perceived themselves as more competent in ICT use compared to other two groups. They also reported that they use ICT more often in lesson preparation and in classroom activities. However, teachers’ perception of possible risks and barriers of ICT use in education did not differ in three educational domains.
Oncogenic KRAS triggers metabolic reprogramming in pancreatic ductal adenocarcinoma
Authors: Shen Xuqing , Niu Ningning , Xue Jing 
Published: November 2022

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely high lethality rate. Oncogenic KRAS activation has been proven to be a key driver of PDAC initiation and progression. There is increasing evidence that PDAC cells undergo extensive metabolic reprogramming to adapt to their extreme energy and biomass demands. Cell-intrinsic factors, such as KRAS mutations, are able to trigger metabolic rewriting. Here, we update recent advances in KRAS-driven metabolic reprogramming and the associated metabolic therapeutic potential in PDAC.
Impact of the Alberta Stroke Program CT Score subregions on long-term functional outcomes in acute ischemic stroke: Results from two multicenter studies in China
Authors: Wang Xinrui , Duan Caohui , Lyu Jinhao , Han Dongshan , Cheng Kun , Meng Zhihua , Wu Xiaoyan , Chen Wen , Wang Guohua , Niu Qingliang , Li Xin , Bian Yitong , Han Dan , Guo Weiting , Yang Shuai , Wang Ximing , Zhang Tijiang , Bi Junying , Wu Feiyun , Xia Shuang , Tong Dan , Duan Kai , Li Zhi , Wang Rongpin , Wang Jinan , Lou Xin 
Published: November 2022

Abstract

Background and Objectives
The Alberta Stroke Program CT Score (ASPECTS) is a widely used rating system for assessing infarct extent and location. We aimed to investigate the prognostic value of ASPECTS subregions’ involvement in the long-term functional outcomes of acute ischemic stroke (AIS).

Materials and Methods
Consecutive patients with AIS and anterior circulation large-vessel stenosis and occlusion between January 2019 and December 2020 were included. The ASPECTS score and subregion involvement for each patient was assessed using posttreatment magnetic resonance diffusion-weighted imaging. Univariate and multivariable regression analyses were conducted to identify subregions related to 3-month poor functional outcome (modified Rankin Scale scores, 3–6) in the reperfusion and medical therapy cohorts, respectively. In addition, prognostic efficiency between the region-based ASPECTS and ASPECTS score methods were compared using receiver operating characteristic curves and DeLong’s test.

Results
A total of 365 patients (median age, 64 years; 70% men) were included, of whom 169 had poor outcomes. In the reperfusion therapy cohort, multivariable regression analyses revealed that the involvement of the left M4 cortical region in left-hemisphere stroke (adjusted odds ratio [aOR] 5.39, 95% confidence interval [CI] 1.53–19.02) and the involvement of the right M3 cortical region in right-hemisphere stroke (aOR 4.21, 95% CI 1.05–16.78) were independently associated with poor functional outcomes. In the medical therapy cohort, left-hemisphere stroke with left M5 cortical region (aOR 2.87, 95% CI 1.08–7.59) and caudate nucleus (aOR 3.14, 95% CI 1.00–9.85) involved and right-hemisphere stroke with right M3 cortical region (aOR 4.15, 95% CI 1.29–8.18) and internal capsule (aOR 3.94, 95% CI 1.22–12.78) affected were related to the increased risks of poststroke disability. In addition, region-based ASPECTS significantly improved the prognostic efficiency compared with the conventional ASPECTS score method.

Conclusion
The involvement of specific ASPECTS subregions depending on the affected hemisphere was associated with worse functional outcomes 3 months after stroke, and the critical subregion distribution varied by clinical management. Therefore, region-based ASPECTS could provide additional value in guiding individual decision making and neurological recovery in patients with AIS.
Memorization: Friend or Foe when Solving Problems in STEM Undergraduate Courses
Authors: DeDecker Sarah , Chouvalova Anastasia , Gordon Karen , Clemmer Ryan , Vale Julie 
Published: November 2022

Problem-solving skill development is an important aspect of student learning in science, technology, engineering, and mathematics (STEM) academic environments, but when solving problems, undergraduate students can choose learning approaches that may either hinder or develop their problem-solving skills. For example, memorization can be used as a learning approach to recall knowledge with or without the intention of understanding course content. Given the diverse roles of memorization in learning, the objective of this study is to investigate student perceptions of the use and importance of memorization when solving problems in STEM undergraduate courses. Focus groups were conducted with students from two Canadian institutions with participation from students enrolled in biology, chemistry, computer science, and engineering majors.
The results indicate that students find memorization valuable in their course contexts and identify the importance of transitioning memorized knowledge to understanding of subject material. Students need time to access and apply knowledge when solving problems and therefore, instructors should design assessments to alleviate time pressures. Instructors should also explain to students when use of memorization is appropriate and which learning approaches will help students develop their problem-solving skills.
The Operator S(a,b;θ_x ) for the Polynomials Z_n (x,y,a,b;q)
Authors: Saad Husam L. , Reshem Faiz A. 
Published: November 2022

In this work, we give an identity that leads to establishing the operator . Also, we introduce the polynomials . In addition, we provide Operator proof for the generating function with its extension and the Rogers formula for . The generating function with its extension and the Rogers formula for the bivariate Rogers-Szegö polynomials are deduced. The Rogers formula for allows to obtain the inverse linearization formula for , which allows to deduce the inverse linearization formula for . A solution to a q-difference equation is introduced and the solution is expressed in terms of the operators . The q-difference method is used to recover an identity of the operator and the generating function for the polynomials .
incongruencias del desarrollo comunitario. Plan Nacional de Desarrollo 2018-2024
Authors: Quiroz Gómez Julio Gerardo 
Published: November 2022

El trabajo que se desarrolla a continuación presenta, a manera de descripción, una serie de incongruencias en materia de políticas de sociales con enfoque de desarrollo comunitario. Cabe mencionar que las incongruencias a señalar no refieren una crítica respecto a la eficiencia y la eficacia en la implementación de política públicas desde el orden de Gobierno Federal, sino que señalan, en el mejor de los casos, problemas de carácter discursivo en cuanto al uso de algunos conceptos teóricos.
Palabras clave
Plan Nacional de Desarrollo 2018-2024, Cohesión social, Desarrollo comunitario
Microstructure-Sensitive Stochastic Design of Polycrystalline Materials for Quasi-Isotropic Properties
Authors: Hasan Mahmudul , Acar Pínar 
Published: November 2022

The present study addresses a multiscale and stochastic design approach for polycrystalline microstructures to achieve a zone of isotropic elastic properties to improve the predictability of the performance of aerospace components. The microstructures are modeled with Orientation Distribution Function (ODF), which is related to the volume densities of crystallographic orientations in a microstructure. The microstructures can have inherent uncertainty due to the variations arising from thermomechanical processing that can alter the component performance. Example design problems are solved for titanium (Ti), aluminum (Al), and galfenol, which are either widely used or have potential applications in the aerospace industry. The level of isotropy for the materials is measured using the available anisotropy index formulas. The optimum microstructure designs are found to provide equivalent stiffness and Young’s modulus values in different directions. Next, property closures for stiffness parameters are generated to demonstrate the ranges of their anisotropy. The closures show that multiple microstructure designs can provide quasi-isotropic elastic properties and the range of material anisotropy is larger for galfenol compared to Ti and Al. Additionally, the stochastic analysis is performed using Gaussian process regression, which is validated with Monte Carlo Simulation. The results show that 10% uncertainty in the ODFs, due to variations in the thermomechanical processing steps, can cause 1.44, 0.44, and 1.02 GPa of standard deviations from the mean values of Young’s modulus for Ti, Al, and galfenol, respectively. However, the effects of the uncertainty are found to be negligibly small for the anisotropy ratio.
ANALISIS PENERAPAN REDUPLIKASI PADA NOVEL GIA THE DIARY OF A LITTLE ANGLE KARYA IRMA IRAWATI
Authors: Mabsuthoh Haninah , Nugraheni Aninditya Sri 
Published: November 2022

Banyak orang yang belum memahami betul tentang kata ulang atau reduplikasi, karena adanya kekeliruan ketika membedakan kata ulang tersebut. Apakah kata ulang tersebut termasuk reduplikasi atau kata dasar yang mengalami pengulangan saja. Maka dari itu, tujuan dari penelitian ini adalah untuk mengetahui jenis kata ulang yang diterapkan dalam novel Gia The Diary of A Little Angle karya Irma Irawati. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa jenis reduplikasi yang diterapkan dalam novel Gia The Diary of A Little Angle karya Irma Irawati adalah kata ulang seluruh, kata ulang sebagian, kata ulang berimbuhan, kata ulang berubah bunyi, dan kata ulang semu. Ditemukan sebanyak 47 kata ulang seluruh, 17 kata ulang sebagian, 5 kata ulang berimbuhan, 1 kata ulang berubah bunyi, dan 4 kata ulang semu.
SENTIMEN WARGANET MAHASISWA TERHADAP COVID-19
Authors: Anggelia Sita , Syaifudin Ahmad 
Published: November 2022

Covid-19 merupakan fenomena alam yang terjadi pada tahun 2020 hingga saat ini. Hal ini berdampak pada kehidupan masyarakat khususnya mahasiswa. Oleh sebab itu perlu dilakukan analisis sentimen untuk menentukan kecenderungan opini mahasiswa terhadap covid-19. Peneliti memilih twitter sebagai objek kajian. Salah satu media online microblogging popular yang digunakan mahaiswa.Twitter merupakan salah satu platform yang digunakan untuk mengekspresikan kondisi terkini setelah covid-19 merambah. Tujuan dari penelitian ini adalah untuk mendeskripsikan penanda yang ditimbulka akibat unggahan tweet mahasiswa terhadap covid-19 serta menghitung tingkat sentimen yang terjadi akibat fenomena alam covid-19 dengan menghasilkan sentimen positif, negative dan netral. Data yang digunakan oleh peniliti diperoleh setelah melakukan pengamatan selama dua hari dari trending topik twitter pada 26 – 27 Januari 2021 menghasilkan 244 tweet dengan memberikan penanda khusus pada unggahan berupa mahasiswa, covid-19 dan daring. Metode yang digunakan dalam penelitian ini memanfaatkan perangkat baru Drone Emprit. Hasil penelitian berupa penanda dan tingkat sentimen yang ada pada media sosial twitter yaitu 75% positif, 24 % negatif dan 0 % netral.
VARIASI URUTAN PERISTIWA DALAM PEMBELAJARAN CERITA PENDEK DI SMP
Authors: Wulansari Ratna , Huda Miftakhul 
Published: November 2022

Logika siswa dapat tercermin dari tulisan siswa. Salah satu bentuk kegiatan pembelajaran menulis yaitu menulis kembali cerita pendek. Siswa memiliki karakter dan cara berpikir sendiri yang sesuai dengan pola pikir yang diinginkan. Perbedaan pola pikir akan menimbulkan perbedaan pada hasil bentuk pemikiran. Hasil tulisan siswa akan berbeda-beda dan memiliki ciri yang dimiliki. Penelitian ini bertujuan menguraikan variasi urutan peristiwa cerita pendek pada siswa kelas IX B SMP N 1 Polanharjo. Jenis penelitian ini merupakan penelitian deskriptif kualitatif. Desain Penelitian ini adalah analisis dokumen. Data berupa urutan peristiwa cerita pendek dalam karangan siswa berdasarkan cerita pendek berjudul Hal Terindah yang Ku Miliki karya Ayu Sulastri di kelas IX B SMP N 1 Polanharjo. Data penelitian ini dikumpulkan dengan teknik dokumentasi. Sumber data penelitian adalah dokumen yang berupa karangan siswa menulis kembali cerita pendek berjudul Hal Terindah yang Ku Miliki karya Ayu Sulastri di kelas IX B SMP N 1 Polanharjo berjumlah 20 siswa di kelas IX B SMP N 1 Polanharjo. Analisis data menggunakan teknik analisis jalinan. Hasil penelitian menunjukkan bahwa variasi urutan peristiwa cerita pendek karangan siswa berdasarkan cerita pendek berjudul Hal Terindah yang Ku Miliki karya Ayu Sulastri di kelas IX B SMP N 1 Polanharjo begitu beragam terdapat 5 variasi urutan peristiwa yang terdapat dari 20 karangan siswa. Bentuk-bentuk variasi urutan peristiwa cerita pendek yaitu, Variasi urutan perisitwa yang ditemukan yaitu (1) Variasi urutan peristiwa runtut sebanyak 5%; (2) Variasi pengurangan urutan peristiwa 55%; (3) variasi pengurangan dan penambahan urutan peristiwa 15%; (4) Variasi pengurangan dan lompatan urutan peristiwa 20%; dan (5) Variasi pengurangan, penambahan, dan lompatan urutan peristiwa 5%. Manfaat penelitian ini diharapkan dapat menambah wawasan dan pengetahuan penulis, pembaca, guru, siswa, dan pencinta sastra dalam memahami variasi urutan peristiwa cerita pendek.
TRANSFORMASI CERPEN MENCARI HERMAN KARYA DEWI LESTARI KE DALAM BENTUK AUDIO SANDIWARA SASTRA MENCARI HERMAN
Authors: Hikmawati Vivi , Sasmika Mira , Hartati Dian 
Published: November 2022

Tujuan yang ingin dicapai dalam penelitian ini adalah mendeskripsikan transformasi cerpen ke dalam podcast Mencari Herman berdasarkan kajian sastra bandingan, dan mendeskripsikan perbandingan unsur intrinsik dan ekstrinsik antara cerpen dan podcast Mencari Herman. Maka peneliti merumuskan dua rumusan masalah dalam penelitian ini, yaitu (1) Bagaimana proses transformasi dari cerpen Mencari Herman ke dalam podcast Mencari Herman?, dan (2) Bagaimana perbandingan unsur intrinsik dan ekstrinsik antara cerpen dan podcast Mencari Herman? Jenis penelitian ini adalah penelitian kepustakaan dengan menggunakan metode deskriptif kualitatif. Sumber data penelitian ini adalah cerpen Mencari Herman karya Dewi Lestari dan podcast Mencari Herman yang disutradarai Gunawan Maryanto. Hasil penelitian ini menunjukkan bahwa cerpen yang ditransformasikan ke dalam bentuk podcast mengakibatkan terjadinya pengurangan, penambahan, dan perubahan variasi. Untuk mengetahui proses transformasi tersebut, peneliti melakukan kajian melalui sastra bandingan. Cerpen lebih memanfaatkan bahasa dan kata-kata sedangkan podcast menggunakan media audio sehingga lebih memanfaatkan kejelasan suara. Dalam hal adaptasi cerpen Mencari Herman ke dalam podcast Mencari Herman, tidak banyak mengalami perubahan yang terjadi, hanya sedikit perubahan narasi pada cerpen menjadi dialog antar tokoh dalam podcast.