bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of ultraviolet light in graduate medical education to assess confidence among residents and fellows in handwashing instruction
Authors: Aouthmany Shaza , Mehalik Haley , Bailey Morgan , Pei Mitchell , Syed Sameer , Brickman Kristopher , Morrison Kayla , Khuder Sadik 
Published: April 2022

Abstract

Background:
Coronavirus disease 2019 (COVID-19) has made it imperative to focus on strategies to improve hand hygiene to minimize threats of viral transmission in hospitals.

Objective:
We investigated the potential of using ultraviolet (UV) light as a visual tool in hand-hygiene education to bring awareness of individual handwashing effectiveness to healthcare workers.

Methods:
In 2020, 117 individuals participated in the simulation and completed surveys on proper handwashing technique. Of these, 114 were first-year residents and fellows. Surveys of confidence in hand hygiene were obtained before and after formal hand-hygiene education utilizing UV light with Glo Germ lotion. The UV light and Glo Germ lotion were used to identify deficiencies in individual handwashing technique.

Results:
With a total response rate of 97.4%, first-year residents and fellows demonstrated a significant decrease in handwashing confidence in pre- and posteducation surveys. Study participants who had had formal hand-hygiene training in the previous 3 years also indicated confidence in hand hygiene similar to those who had not had previous hand-hygiene training. Conclusions: Overall, resident interns and fellows may have falsely elevated their hand-hygiene confidence levels. However, conclusions regarding the confidence of residents and fellows individually could not be made due to sample size. Many healthcare personnel practice improper handwashing techniques, which may be improved with education and training that includes UV light.
Comparison of aerosol mitigation strategies and aerosol persistence in dental environments
Authors: Choudhary Shruti , Durkin Michael J. , Stoeckel Daniel C. , Steinkamp Heidi M. , Thornhill Martin H. , Lockhart Peter B. , Babcock Hilary M. , Kwon Jennie H. , Liang Stephen Y. , Biswas Pratim 
Published: April 2022

AbstractObjective:To determine the impact of various aerosol mitigation interventions and to establish duration of aerosol persistence in a variety of dental clinic configurations.Methods:We performed aerosol measurement studies in endodontic, orthodontic, periodontic, pediatric, and general dentistry clinics. We used an optical aerosol spectrometer and wearable particulate matter sensors to measure real-time aerosol concentration from the vantage point of the dentist during routine care in a variety of clinic configurations (eg, open bay, single room, partitioned operatories). We compared the impact of aerosol mitigation strategies (eg, ventilation and high-volume evacuation (HVE), and prevalence of particulate matter) in the dental clinic environment before, during, and after high-speed drilling, slow–speed drilling, and ultrasonic scaling procedures.Results:Conical and ISOVAC HVE were superior to standard-tip evacuation for aerosol-generating procedures. When aerosols were detected in the environment, they were rapidly dispersed within minutes of completing the aerosol-generating procedure. Few aerosols were detected in dental clinics, regardless of configuration, when conical and ISOVAC HVE were used.Conclusions:Dentists should consider using conical or ISOVAC HVE rather than standard-tip evacuators to reduce aerosols generated during routine clinical practice. Furthermore, when such effective aerosol mitigation strategies are employed, dentists need not leave dental chairs fallow between patients because aerosols are rapidly dispersed.
Balance as a Pre-Estimation Test for Time Series Analysis
Authors: Pickup Mark , Kellstedt Paul M. 
Published: April 2022

AbstractIt is understood that ensuring equation balance is a necessary condition for a valid model of times series data. Yet, the definition of balance provided so far has been incomplete and there has not been a consistent understanding of exactly why balance is important or how it can be applied. The discussion to date has focused on the estimates produced by the general error correction model (GECM). In this paper, we go beyond the GECM and beyond model estimates. We treat equation balance as a theoretical matter, not merely an empirical one, and describe how to use the concept of balance to test theoretical propositions before longitudinal data have been gathered. We explain how equation balance can be used to check if your theoretical or empirical model is either wrong or incomplete in a way that will prevent a meaningful interpretation of the model. We also raise the issue of “
$I(0)$
balance” and its importance.
‘Win-win’ contested: negotiating the privatisation of Africa's Freedom Railway with the ‘Chinese of today’
Authors: Zajontz Tim 
Published: April 2022

AbstractAs infrastructure development has become a key ingredient in Africa–China relations, the role of African governments in co-determining the design, funding and governance of the continent's infrastructures has come under close scrutiny. This article sheds light on the rehabilitation of a symbol of Sino–African friendship: the Tanzania–Zambia Railway Authority (TAZARA). Employing Jessop's strategic-relational approach, it is shown that the strategies of the shareholding governments in the negotiations with a Chinese consortium were informed by strategic learning from previous railway privatisations, corresponding cost–benefit analyses and reflection about Chinese commercial interests. Zambia's indebtedness and Tanzania's autocratic developmental state under President Magufuli formed crucial elements of the structural context in which the fate of Africa's Freedom Railway was negotiated. The article transcends both crudely structuralist accounts of a supposedly all-powerful China and voluntarist conceptions of African agency that are void of structure. Assessing (African) agency requires analytical sensitivity towards the dialectical interaction between specific strategic capacities and strategically selective political–economic contexts.
Outbreak of delta variant SARS-CoV-2 virus on a psychogeriatric ward in Helsinki, Finland, August 2021: two-dose vaccination reduces mortality and disease severity amongst the elderly
Authors: Malik Adnan , Lehtola Laura , Isosomppi Sanna , Smura Teemu , Saarenheimo Jaana , Anttila Veli-Jukka , Särelä Eeva 
Published: April 2022

Abstract
We describe an outbreak of delta variant SARS-CoV-2 on a psychogeriatric ward of elderly patients. Retrospectively collected data was analysed using Fisher's exact test to assess the association between patients’ vaccination status and infection rates, severity of disease and mortality. Vaccination with two doses was shown to reduce severity of disease (5% vs. 75%, p < 0.001) and mortality (5% vs. 50%, p < 0.018) amongst an elderly inpatient population during an outbreak of delta variant SARS-CoV-2. Vaccination should be encouraged in elderly care institutions. Furthermore, adequate vaccination in elderly care institutions is an important consideration in current booster (third/fourth) dose schedules.
The impact of alcohol control policy on pneumonia mortality in Lithuania: an interrupted time-series analysis
Authors: Zafar Anush , Rehm Jürgen , Feng Xinyang , Jiang Huan , Kim Kawon Victoria , Manthey Jakob , Radišauskas Ričardas , Štelemėkas Mindaugas , Petkevičienė Janina , Tran Alexander , Lange Shannon 
Published: April 2022

Abstract
Despite the growing body of evidence suggesting that alcohol consumption is associated with an increased risk of and poorer treatment outcomes from pneumonia, little is known about the association between alcohol control policy and pneumonia mortality. As such, this study aimed to assess the impact of three alcohol control policies legislated in 2008, 2017 and 2018 in Lithuania on sex-specific pneumonia mortality rates among individuals 15+ years of age. An interrupted time-series analysis using a generalised additive mixed model was performed for each policy. Of the three policies, only the 2008 policy resulted in a significant slope change (i.e. decline) in pneumonia mortality rates among males; no significant slope change was observed among females. The low R2 values for all sex-specific models suggest that other external factors are likely also influencing the sex-specific pneumonia mortality rates in Lithuania. Overall, the findings from this study suggest alcohol control policy's targeting affordability may be an effective way to reduce pneumonia mortality rates, among males in particular. However, further research is needed to fully explore their impact.
Frontal EEG asymmetry moderates the relation between borderline personality disorder features and feelings of social rejection in adolescents
Authors: Stead Victoria E. , Schmidt Louis A. , Crowley Michael J. , Dyce Lisa , Hall Geoffrey B. , Van Lieshout Ryan J. , Boylan Khrista 
Published: April 2022

AbstractAlthough associations among borderline personality disorder (BPD), social rejection, and frontal EEG alpha asymmetry scores (FAA, a neural correlate of emotion regulation and approach-withdrawal motivations) have been explored in different studies, relatively little work has examined these relations during adolescence in the same study. We examined whether FAA moderated the relation between BPD features and rejection sensitivity following a validated social exclusion paradigm, Cyberball. A mixed, clinical-community sample of 64 adolescents (females = 62.5%;Mage = 14.45 years;SD= 1.6; range = 11-17 years) completed psychodiagnostic interviews and a self-report measure of BPD (Time 1). Approximately two weeks later (Time 2), participants completed a resting EEG recording followed by Cyberball. FAA moderated the relation between BPD features and overall feelings of rejection following Cyberball: individuals with greater relative left FAA had the highest and lowest feelings of social rejection depending on whether they had high and low BPD feature scores, respectively. Results remained after controlling for age, sex, gender, depression, and BPD diagnosis. These results suggest that FAA may moderate the relation between BPD features and social rejection, and that left frontal brain activity at rest may be differentially associated with those feelings in BPD. Findings are discussed in terms of the link between left frontal brain activity in the regulation and dysregulation of social approach behaviors, characteristic of BPD.
Should the government subsidize innovation or automation?
Authors: Chu Angus C. , Cozzi Guido , Furukawa Yuichi , Liao Chih-Hsing 
Published: April 2022

AbstractThis study introduces automation into a Schumpeterian growth model to explore the effects of R&D and automation subsidies. R&D subsidy increases innovation and growth but decreases the share of automated industries and the degree of capital intensity in the aggregate production function. Automation subsidy has the opposite effects on these macroeconomic variables. Calibrating the model to US data, we find that raising R&D subsidy increases the welfare of high-skill workers but decreases the welfare of low-skill workers and capital owners, whereas increasing automation subsidy increases the welfare of high-skill workers and capital owners but decreases the welfare of low-skill workers. Therefore, whether the government should subsidize innovation or automation depends on how it evaluates the welfare gains and losses of different agents in the economy.
Caregivers’ provision of sweetened fruit-flavoured drinks to young children: importance of perceived product attributes and differences by socio-demographic and behavioural characteristics
Authors: Choi Yoon Y , Jensen Melissa L , Fleming-Milici Frances , Harris Jennifer L 
Published: April 2022

AbstractObjective:Drinks containing added sugar and/or non-nutritive sweeteners are not recommended for children under 6 years. Yet, most young children consume these products. The current study examined factors associated with caregivers’ provision of sweetened drinks to their young child.Design:Caregivers reported frequency of providing sweetened fruit-flavoured drinks (fruit drinks and flavoured water) and unsweetened juices (100 % juice and juice/water blends) to their 1- to 5-year-old child in the past month and perceived importance of product attributes (healthfulness, product claims and other characteristics), other drinks provided, reading the nutrition facts panel and socio-demographic characteristics. A partial proportional odds model measured the relationship between these factors and frequency of providing sweetened fruit-flavoured drinks.Setting:Online cross-sectional survey.Participants:U.S. caregivers (n 1763) with a young child (ages 1–5).Results:The majority (74 %) of caregivers provided sweetened fruit-flavoured drinks to their child in the past month; 26 % provided them daily. Provision frequency was positively associated with some drink attributes, including perceived healthfulness, vitamin C claims and box/pouch packaging; child requests and serving other sweetened drinks and juice/water blends. Provision frequency was negatively associated with perceived importance of ‘no/less sugar’ and ‘all natural’ claims. Reading nutrition facts panels, serving water to their child and child’s age were not significant.Conclusion:Misunderstanding of product healthfulness and other marketing attributes contribute to frequent provision of sweetened drinks to young children. Public health efforts to address common misperceptions, including counter marketing, may raise awareness among caregivers about the harms of providing sweetened drinks to young children.
Biased Witnesses: Crystal Thermal Records May Give Conflicting Accounts of Magma Cooling
Authors: Culha C. , Keller T. , Suckale J. 
Published: April 2022

AbstractCrystals retain an imprint of the dynamic changes within a magma reservoir and hence contain invaluable information about the evolving conditions inside volcanic plumbing systems. However, instead of telling a single, simple story, they comprise overprinted evidence of numerous processes relating to temperature, pressure and composition that drive crystal precipitation and dissolution in magmatic systems. To decipher these different elements in the story that crystals tell, we attempt to identify the observational signatures of a simple, yet ubiquitous process: crystal precipitation and dissolution during magma cooling. To isolate this process in a complex magmatic system with intricate dynamic feedbacks, we assume that synthetic crystals precipitate and dissolve rapidly in response to deviations from thermodynamic equilibrium. In our crystalline‐scale simulations, synthetic crystals drag along the cooler‐than‐ambient melt in which they precipitated and can drive a temperature‐dependent, crystal‐driven convection. We analyze the non‐dimensional conditions for this coupled convection and record the heterogeneous thermal histories that synthetic crystals in this flow regime experience. We show that many synthetic crystals dissolve, loosing their thermal record of the convection. Based on our findings, we suggest that heterogeneity in the thermal history of crystals is more indicative of local, crystal‐scale processes than the overall, system‐wide cooling trend.
Effect of natural and commercially produced juices on colour stability of microhybrid and nanohybrid composites
Authors: Meshki Razieh , Rashidi Marjan 
Published: April 2022

Abstract
Objective
This study aims to evaluate the discoloration rate of two types of composites, microhybrid and nanohybrid, after exposure to natural and commercially-produced juices.

Materials and methods
In this experimental study, 90 disc-shaped specimens with a thickness of 2 mm and a diameter of 10 mm were taken from two composites, microhybrid P4 (Kerr-ITALY) and nanohybrid Filtek Z250XT (3M-ESPE-USA) (two groups of 45). Then, the samples of each group were divided into five subgroups of nine and were immersed for 10 days for 4 h in five solutions of commercially-produced orange juice, natural orange juice, commercially-produced pomegranate juice, natural pomegranate juice, and distilled water (control group). The colour of the samples was measured by a reflective spectrophotometer using the CLEl*a*b colour space at baseline and after discoloration.

Result
The independent t-test showed that the mean discoloration rate (∆E) of nanohybrid composite exposed to commercially-produced orange juice, natural pomegranate juice, and commercially-produced pomegranate juice was significantly higher than microhybrid composite (P < 0.01). In addition, the test found that the highest discoloration rate of the nanohybrid composite was related to the effect of commercially-produced orange juice (∆E = 13.03) and the highest discoloration rate of microhybrid composite was related to the effect of natural pomegranate juice (∆E = 4.79).

Conclusion
According to the results, it seems that microhybrid composites are more resistant to discoloration than nanohybrid composites. According to the results, consumption of dyed drinks, particularly natural pomegranate juice, commercially-produced orange juice, and commercially-produced pomegranate juice, is not recommended in the first few days after composite restoration.
Adding bendamustine to melphalan before ASCT improves CR rate in myeloma vs. melphalan alone: A randomized phase-2 trial
Authors: Farag Sarah , Bacher Ulrike , Jeker Barbara , Legros Myriam , Rhyner Gaelle , Lüthi Jean-Marc , Schardt Julian , Zander Thilo , Daskalakis Michael , Mansouri Behrouz , Manz Chantal , Pabst Thomas 
Published: April 2022

AbstractDefinite cure remains exceptional in myeloma patients even after high-dose chemotherapy (HDCT) with melphalan (Mel) and autologous stem cell transplantation (ASCT). Thus, improving efficacy of HDCT in MM remains an unresolved issue. This randomized phase II trial compared standard 200 mg/m2 Mel HDCT to experimental HDCT with 200 mg/m2 bendamustine, given both at days −4 and −3, combined with 100 mg/m2 melphalan at days −2 and −1 (BenMel) before ASCT as first-line consolidation in myeloma patients. The primary endpoint aimed to identify at least a 15% improvement in the complete remission rate (stringent CR + CR) after HDCT with BenMel compared with Mel alone. A total of 120 MM patients were 1:1 randomized. The rate of sCR/CR after ASCT was higher in BenMel than in Mel treated patients (70.0% vs. 51.7%; p = 0.039). Three patients in the BenMel group (5.0%) had reversible acute renal insufficiency compared with none in Mel patients. Minimal residual disease negativity (<10-5) by flow cytometry was observed in 26 (45.6%) BenMel patients and 22 (37.9%) in the Mel group (p = 0.375). Our data suggest that BenMel HDCT is safe and improves the sCR/CR rate compared with standard Mel alone.
Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic
Authors: Tontsch-Grunt Ulrike , Traexler Paula-Elena , Baum Anke , Musa Hanny , Marzin Kristell , Wang Shaonan , Trapani Francesca , Engelhardt Harald , Solca Flavio 
Published: April 2022

Abstract
Background
BET inhibitors have been tested in several clinical trials where, despite encouraging preclinical results, substantial clinical benefit in monotherapy remains limited. This work illustrates the translational challenges and reports new data around the novel BET inhibitor, BI 894999. At clinically achievable concentrations, mechanistic studies were carried out to study pathway modulation and rational drug combinations.

Methods
BRD-NUT fusions are oncogenic drivers in NUT carcinoma (NC). The effects of BI 894999 on proliferation, chromatin binding and pathway modulation were studied in NC in vitro. These studies were complemented by efficacy studies either as a single agent or in combination with the clinical p300/CBP inhibitor CCS1477.

Results
Based on the modelling of preclinical and clinical data, we proposed and implemented a new clinical scheduling regimen. This led to plasma levels sufficient to fully dislodge BRD-NUT from chromatin and to sustained and pronounced pharmacodynamic (PD) modulation of HEXIM1 and HIST2H2BF. Platelet counts in patient blood samples were improved compared to previous schedules. Rational combination studies of BI 894999 performed at clinically meaningful concentrations led to tumour regressions in all NC xenograft models tested.

Conclusions
BI 894999 holds significant potential as a combination drug and CCS1477 p300/CBP inhibitor is a promising partner for future clinical trials.
Implication of autophagy in the antifibrogenic effect of Rilpivirine: when more is less
Authors: Lucantoni Federico , Benedicto Ana M. , Gruevska Aleksandra , Moragrega Ángela B. , Fuster-Martínez Isabel , Esplugues Juan V. , Blas-García Ana , Apostolova Nadezda 
Published: April 2022

AbstractAs the main extracellular matrix-producing cells, activated hepatic stellate cells (HSC) are fundamental mediators of liver fibrosis (LF), and understanding their activation/inactivation mechanisms is paramount to the search for novel therapeutics. The antiretroviral drug Rilpivirine (RPV) has demonstrated a hepatoprotective effect in several animal models of chronic liver injury that is related to its antifibrogenic and apoptotic action in HSC. In the present study, we evaluated whether autophagy is implicated in the hepatoprotective action of RPV, as autophagy plays an important role in HSC transdifferentiation. We employed two standard mouse models of chronic liver injury - fatty liver disease and carbon tetrachloride (CCl4)-induced hepatotoxicity -and cultured HSC activated with the profibrotic cytokine TGF-β. RPV enhanced autophagy in the whole liver of both mouse models and in activated HSC, evident in the protein expression of autophagy markers, increased autophagosome content and lysosomal mass. Moreover, increased autophagic flux was observed in RPV-exposed HSC as revealed by tandem fluorescence-tagged LC3 and p62 and analysis of LC3-II accumulation in cells exposed to the lysosomal inhibitor chloroquine. Importantly, autophagy was involved in the cytotoxic effect of RPV on HSC, though in a differential manner. Pharmacological inhibition of autophagy by 3-methyladenine (3-MA) did not affect the diminishing effect of RPV on viability, while treatment with wortmannin or depletion of specific autophagy proteins (ATG5, Beclin-1 and SQSTM1/p62) rescued the detrimental effect of high concentrations of RPV on the viability of activated HSC. Finally, we also provide evidence that RPV compromises the viability of TGF-β-induced HSC independently of its antifibrogenic effect, observed as reduced collagen 1A1 synthesis, and that this effect does not include RPV´s modulation of autophagy. In summary, as a contributor to the mechanisms involved in the hepatoprotective action of RPV, autophagy may be a good candidate to explore when developing novel therapeutics for LF.