bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of prevalence and risk factors of diabetes and pre-diabetes in South Africa
Authors: Grundlingh Nina , Zewotir Temesgen T. , Roberts Danielle J. , Manda Samuel 
Published: March 2022

Abstract
Background
Diabetes prevalence, as well as that of pre-diabetes, is rapidly increasing in South Africa. Individuals with pre-diabetes have a high risk of developing type 2 diabetes, which is reversible with a change in lifestyle. If left untreated, diabetes can lead to serious health complications. Our objective was to assess the prevalence of diabetes and pre-diabetes, and to investigate the associated risk factors of each in the South African population.

Method
This study made use of the South African Demographic Health Survey 2016 data. The study participants included 6442 individuals aged 15 years and older. A generalized additive mixed model was employed to account for the complex survey design of the study as well as well spatial autocorrelation in the data.

Results
The observed prevalence of pre-diabetes and diabetes was 67% and 22%, respectively. Among those who had never been tested for diabetes prior to the survey, 10% of females and 6% of males were found to be diabetic, and 67% of both males and females were found to be pre-diabetic. Thus, a large proportion of the South African population remains undiagnosed. The model revealed both common and uncommon factors significantly associated with pre-diabetes and diabetes. This highlights the importance of considering diabetic status as a three-level categorical outcome, rather than binary. In addition, significant interactions between some of the lifestyle factors, demographic factors and anthropometric measures were revealed, which indicates that the effects each these factors have on the likelihood of an individual being pre-diabetic or diabetic is confounded by other factors.

Conclusion
The risk factors for diabetes and pre-diabetes are many and complicated. Individuals need to be aware of their diabetic status before health complications arise. It is therefore important for all stakeholders in government and the private sector of South Africa to get involved in providing education and creating awareness about diabetes. Regular testing of diabetes, as well as leading a healthy lifestyle, should be encouraged.
Theoretical basis for phase field modeling of polycrystalline grain growth using a spherical-Gaussian-based 5-D computational approach
Authors: Yeo Lenissongui C. , Costa Michael N. , Bair Jacob L. 
Published: March 2022

AbstractUsing a previously developed phase field modeling method, where interface energies are described by spherical gaussians that allow the modeling of complex anisotropies, a new phase field model was developed to model 5-D anisotropy in polycrystalline grain growth. We present the use of quaternions, assigned to individual grains as orientations and misorientations for grain boundaries, as a means of simulating the ongoing mesoscale changes during anisotropic polycrystalline grain growth. The full 5-D landscape is scanned in MATLAB, and the grain boundary (GB) energy of each grain boundary is calculated from the continuous function developed by Bulatov et al. MATLAB is then used to find all local minima in the GB energy which are stored for use in the phase field model. The methodology of including these minima in the phase field model involves using 2-D gaussian switches, which match the misorientation between grains with misorientations for the GB energy minima. Within a threshold range of the minima misorientation, the switch activates a spherical Gaussian to set the GB energy to the desired value creating in combination a full 5D GB energy space. This creates a GB energy that morphs in real time and space as the GB plane or grain orientations change. Implementation methods of the model are outlined for the Multiphysics Object Oriented Simulation Environment (MOOSE), where reduced order parameters still retain individual grain identification useful for individually assigned quaternions.
Successful medical treatment of west syndrome with a KCNA2 variant: a case report
Authors: Wang Han , Zhu Yanwei , Cao Dezhi , Chen Hong , Ding Xin , Zeng Qi , Zou Huafang , Liao Jianxiang 
Published: March 2022

Abstract
Background
West syndrome is a devastating disorder characterized by a triad of epileptic spasms, abnormal electroencephalography (EEG), and developmental arrest or psychomotor delay. In addition to early diagnosis, knowing the etiology of the condition is also important for its treatment. Among various etiologies, the genetic factors, especially mutations of ion channel genes, are very common and strongly linked to West syndrome.

Case presentation
A boy who had epileptic spasms from the age of 4 months was diagnosed with West syndrome based on the clinical manifestation and EEG results in Shenzhen Children’s Hospital in June 2019. Trios whole-exome sequencing (WES) test and protein structural model prediction were performed. We also reviewed the clinical and genetic features of this syndrome and the mechanisms of action of topiramate (TPM) by literature search in databases of Online Mendelian Inheritance in Man, Clinical Genome Resource, PubMed, Chinese National Knowledge Infrastructure and Wanfang database using keywords “KCNA2” “West syndrome” and “Topiramate” by December 2020. The relationship between the effect of TPM and the pathogenesis of the KCNA2 variant was also assessed. The WES test revealed c.244C > T/p. Arg82Cys varaint of KCNA2 (NM_004974.3) in this patient, and Sanger sequencing identified this was a de novo mutation. As far as we know, this is the first report of the c.244C > T/p. Arg82Cys variant in KCNA2, which was likely a pathogenic mutation. The seizures were successfully controlled for 10 months by TPM after failure of sodium valproate, large doses of vitamin B6, and adrenocorticotropic hormone. We speculate that the therapeutic effect of TPM in this patient is partially due to the inhibition of carbonic anhydrase.

Conclusions
Mutations in the KCNA2 gene should be considered for patients with West syndrome. The TPM treatment is probably effective for KCNA2-associated disorders.
Artificial intelligence in orthopedic surgery: evolution, current state and future directions
Authors: Kurmis Andrew P. , Ianunzio Jamie R. 
Published: March 2022

AbstractTechnological advances continue to evolve at a breath-taking pace. Computer-navigation, robot-assistance and three-dimensional digital planning have become commonplace in many parts of the world. With near exponential advances in computer processing capacity, and the advent, progressive understanding and refinement of software algorithms, medicine and orthopaedic surgery have begun to delve into artificial intelligence (AI) systems. While for some, such applications still seem in the realm of science fiction, these technologies are already in selective clinical use and are likely to soon see wider uptake. The purpose of this structured review was to provide an understandable summary to non-academic orthopaedic surgeons, exploring key definitions and basic development principles of AI technology as it currently stands. To ensure content validity and representativeness, a structured, systematic review was performed following the accepted PRISMA principles. The paper concludes with a forward-look into heralded and potential applications of AI technology in orthopedic surgery.While not intended to be a detailed technical description of the complex processing that underpins AI applications, this work will take a small step forward in demystifying some of the commonly-held misconceptions regarding AI and its potential benefits to patients and surgeons. With evidence-supported broader awareness, we aim to foster an open-mindedness among clinicians toward such technologies in the future.
Endovascular treatment of femoral artery blow-out caused by skin malignancy
Authors: Hekimoglu Azad , Ergun Onur , Birgi Erdem , Balas Sener 
Published: March 2022

Abstract
Background
Vascular blow-out syndrome is a life-threatening bleeding condition that usually occurs in the carotid arteries as a result of invasion of head and neck malignant tumors. There are several case reports in the literature on peripheral vascular blow out. To our knowledge, there is no other case report in the literature on blow-out in the femoral artery secondary to skin malignancy.

Case presentation
A 66-year-old male patient, who was diagnosed with skin squamous cell carcinoma (SCC) as a result of tissue sampling due to redness and stiffness in the left inguinal region, underwent emergency surgery with severe bleeding. Since edema and deformations on the skin did not render the operation possible, the patient was taken to the interventional radiology unit by applying pressure compression onto the bleeding area for urgent endovascular treatment. The patient was treated with a stent-graft.

Conclusion
The femoral blow-out is an emergency condition that needs to be managed aggressively, and if left untreated, it can cause serious bleeding, limb ischemia, limb loss, or death. Endovascular stent-graft placement is the first method that should be considered, and this method provides fast and effective treatment.
Potentials of N-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol as novel charge transfer acceptors in pharmaceutical analysis of some quinolones and cephalosporins
Authors: Umoh O. E. , Adegoke O. A. , Effiong D. E. 
Published: March 2022

AbstractBackgroundQuinolones and cephalosporins are antibiotic agents with activity against Gram-positive and Gram-negative bacteria. They contain chromophores and amine groups which are electron-rich centres capable of donating electrons to electron-deficient compounds. A survey of the literature revealed that 2, 4-dinitro-1-naphthol, a nitroaromatic useful in chemical synthesis, can accept electrons in charge transfer reactions. This work investigatesN-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol in the formation of charge transfer complexes by accepting electrons from selected quinolones and cephalosporins. Five other nitroaromatics (i.e. 4-nitro-1-naphthylamine, 2-nitro-1-naphthol, 2,4-dinitro-1-naphthylamine, 1-nitronaphthalene and 1,4-dinitronaphthalene) were screened in addition to the aforementioned and compared for charge transfer complexes formation. Spot test was used to establish charge transfer complex formation at room and elevated temperatures with determination done by visual inspection and thin layer chromatographic analysis of the reaction mixture. Ultraviolet visible absorption spectroscopy was used to estimate the extent of complexes.ResultsOnly solutions of adducts ofN-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol gave instant and distinct colour with each drug used at room and elevated temperature. While the former gave deep golden yellow, the latter gave golden yellow against their blank reagent solutions which were, lemon and greenish yellow respectively. Visual inspections of 2-nitro-1-naphthol adduct solutions showed no colour change from the yellow colour of the blank reagent solution, even though the Ultraviolet visible absorption spectra revealed the formation of charge transfer complexes. The adducts solutions of 4-nitro-1-naphthylamine, 2,4-dinitro-1-naphthylamine, 1-nitronaphthalene and 1,4-dinitronaphthalene showed no colour change from their blank reagent solutions and their Ultraviolet visible absorption spectra revealed no formation of charge transfer complexes.ConclusionUltraviolet visible absorption spectral analysis shows superiority ofN-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol in charge-transfer complex formation over other nitroaromatics screened.N-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol are good acceptors of electrons from these drugs, hence could be useful as charge transfer reagents in ultraviolet visible spectrophotometric analysis of these drugs.
Stability over time of scores on psychiatric rating scales, questionnaires and cognitive tests in healthy controls
Authors: Stahl Katharina , Adorjan Kristina , Anderson-Schmidt Heike , Budde Monika , Comes Ashley L. , Gade Katrin , Heilbronner Maria , Kalman Janos L. , Klöhn-Saghatolislam Farahnaz , Oraki Kohshour Mojtaba , Papiol Sergi , Reich-Erkelenz Daniela , Schaupp Sabrina K. , Schulte Eva C. , Senner Fanny , Vogl Thomas , Wiltfang Jens , Reininghaus Eva , Falkai Peter , Schulze Thomas G. , Bickeböller Heike , Heilbronner Urs 
Published: March 2022

BackgroundCase-only longitudinal studies are common in psychiatry. Further, it is assumed that psychiatric ratings and questionnaire results of healthy controls stay stable over foreseeable time ranges. For cognitive tests, improvements over time are expected, but data for more than two administrations are scarce.AimsWe comprehensively investigated the longitudinal course for trends over time in cognitive and symptom measurements for severe mental disorders. Assessments included the Trail Making Tests, verbal Digit Span tests, Global Assessment of Functioning, Inventory of Depressive Symptomatology, the Positive and Negative Syndrome Scale, and the Young Mania Rating Scale, among others.MethodUsing the data of control individuals (n = 326) from the PsyCourse study who had up to four assessments over 18 months, we modelled the course using linear mixed models or logistic regression. The slopes or odds ratios were estimated and adjusted for age and gender. We also assessed the robustness of these results using a longitudinal non-parametric test in a sensitivity analysis.ResultsSmall effects were detected for most cognitive tests, indicating a performance improvement over time (P < 0.05). However, for most of the symptom rating scales and questionnaires, no effects were detected, in line with our initial hypothesis.ConclusionsThe slightly but consistently improved performance in the cognitive tests speaks of a test-unspecific positive trend, while psychiatric ratings and questionnaire results remain stable over the observed period. These detectable improvements need to be considered when interpreting longitudinal courses. We therefore recommend recruiting control participants if cognitive tests are administered.
PLIN1 Haploinsufficiency Causes a Favorable Metabolic Profile
Authors: Patel Kashyap A , Burman Shivang , Laver Thomas W , Hattersley Andrew T , Frayling Timothy M , Weedon Michael N 
Published: March 2022

Abstract

Context
PLIN1 encodes perilipin-1, which coats lipid droplets in adipocytes and is involved in droplet formation, triglyceride storage, and lipolysis. Rare PLIN1 frameshift variants that extend the translated protein have been described to cause lipodystrophy.

Objective
This work aimed to test whether PLIN1 protein-truncating variants (PTVs) cause lipodystrophy in a large population-based cohort.

Methods
We identified individuals with PLIN1 PTVs in individuals with exome data in the UK Biobank. We performed gene-burden testing for individuals with PLIN1 PTVs. We replicated the associations using data from the T2D Knowledge portal. We performed a phenome-wide association study using publicly available association statistics. A total of 362 791 individuals in the UK Biobank, a population-based cohort, and 43 125 individuals in the T2D Knowledge portal, a type 2 diabetes (T2D) case-control study, were included in the analyses. Main outcome measures included 22 diseases and traits relevant to lipodystrophy.

Results
The 735 individuals with PLIN1 PTVs had a favorable metabolic profile. These individuals had increased high-density lipoprotein cholesterol (0.12 mmol/L; 95% CI, 0.09 to 0.14, P = 2 × 10–18), reduced triglycerides (–0.22 mmol/L; 95% CI, –0.29 to –0.14, P = 3 × 10–11), reduced waist-to-hip ratio (–0.02; 95% CI, –0.02 to –0.01, P = 9 × 10–12), and reduced systolic blood pressure (–1.67 mm Hg; 95% CI, –3.25 to –0.09, P = .05). These associations were consistent in the smaller T2D Knowledge portal cohort. In the UK Biobank, PLIN1 PTVs were associated with reduced risk of myocardial infarction (odds ratio [OR] = 0.59; 95% CI, 0.35 to 0.93, P = .02) and hypertension (OR = 0.85; 95% CI, 0.73 to 0.98, P = .03), but not T2D (OR = 0.99; 95% CI, 0.63-1.51, P = .99).

Conclusion
Our study suggests that PLIN1 haploinsufficiency causes a favorable metabolic profile and may protect against cardiovascular disease.
Progesterone Receptor Status of Epithelial Cells as a Predictive Marker for Postoperative Recurrence of Endometriosis
Authors: Tarumi Yosuke , Mori Taisuke , Shimura Koki , Izumi Yuko , Okimura Hiroyuki , Kataoka Hisashi , Kokabu Tetsuya , Ito Fumitake , Koshiba Akemi , Khan Khaleque N , Kusuki Izumi , Kitawaki Jo 
Published: March 2022

AbstractContextProgesterone resistance including progesterone receptor (PR) deficiency contributes to the pathophysiology of endometriosis; however, whether the PR expression levels in ovarian endometrioma (OE) correlate with the postoperative recurrence of endometriosis remains unclear.ObjectiveThis study aimed to investigate the association between PR expression levels in OE and the recurrence of endometriosis.MethodsOE specimens were obtained from 132 patients who underwent conservative surgery for endometriosis. The PR expression levels were evaluated using the H score after immunohistochemical staining.ResultsOf the 132 patients, 36 (27.3%) experienced recurrence and 96 (72.7%) did not. No differences were observed in the patient characteristics between the recurrence and nonrecurrence groups except for follow-up period. PR immunoreactivity in the epithelial cells (ECs) was statistically significantly lower in the recurrent group than in the nonrecurrent group (P &lt; .01); however, this change was not observed in the stromal cells. Moreover, multivariable logistic regression analysis revealed that the H score of PR in ECs was an independent factor and was statistically significantly associated with the recurrence of endometriosis (P = .01). Furthermore, we divided the patients into PR-negative or PR-positive groups. The cumulative recurrence rate in the negative PR group was statistically significantly higher than that in the positive PR group (P = .046).ConclusionLow PR expression levels in OE-ECs may predict the recurrence of endometriosis. The PR status in OE-ECs is associated with the pathophysiology of the recurrence of endometriosis, and optimized postoperative management for endometriosis may be provided by referring to the PR status.
Structure of Aqueous Scandium(III) Nitrate Solution by Large-Angle X-ray Scattering Combined with Empirical Potential Refinement Modeling, X-ray Absorption Fine Structure, and Discrete Variational Xα Calculations
Authors: Yamaguchi Toshio , Higa Sota , Yoshida Koji , Sumitani Kazushi , Kurisaki Tsutomu 
Published: March 2022

Abstract
Large-Angle X-ray scattering (LAXS) and Sc K X-ray absorption near-edge structure (XANES) measurements are made at room temperature on a 1 M (= mol dm−3) Sc(NO3)3 aqueous solution. The X-ray interference function is subjected to an empirical potential structure refinement (EPSR) modeling to extract the site-site pair correlation functions, the coordination number distribution, and the spatial density functions (three-dimensional structure). The LAXS analysis combined with EPSR reveals that Sc3+ is surrounded by six or seven water molecules and one oxygen atom of NO3− with an Sc3+-Ow (H2O) and Sc3+-ON (NO3−) distance of 2.14 Å. NO3− has a weak solvation shell with a broad distribution of coordination numbers with the highest population of nine at an N-Ow distance of 3.66 Å. Solvent water forms the tetrahedral network structure. The XANES spectrum is compared with simulated spectra on various coordination geometries of an ScO7 moiety with a discrete variational Xα (DV-Xα) molecular orbital (MO) method. A distorted monocapped trigonal prism structure of Sc3+ best reproduced the experimental pre-peak due to the Sc 1s → 3d transition in the XANES spectrum.
The Impact of Green Practices in Value Chain on Firm Performance in the Context of a Developing Country
Authors: Ong Jeen Wei , Goh Gerald Guan Gan , Yong Sally Hui Siang 
Published: March 2022

Background: Companies need to go green to remain relevant. Previous studies have confirmed that going green leads to superior performance for companies. However, research of green practices in a value chain requires further attention, especially in identifying the green value chain activities that lead to superior performance. A value chain analysis focuses on identifying competitive advantages of firms through five primary and four support activities. Methods: This study extends from Ong et al. (2019), who developed and validated the instrument for the nine green value chain activities, to also examine their effect on firm performance. The 207 valid responses in this study are collected through a questionnaire survey of the sampling frame consisting of companies in Bursa Malaysia and the Federation of Malaysian Manufacturers Directory. Results: The findings reveal that the companies’ green practices in primary value chain activities are higher than in the supporting value chain activities. Technological development is the activity with the lowest green attention among the nine value chain activities. Our multiple regression analysis shows that 25% of the variation in firm performance can be significantly explained by the nine green value chain activities. In terms of the individual green value chain activities, green technology development is the only activity that can positively and significantly explain firm performance. Conclusions: The findings of the study suggest that companies intending to build their green core competence need to engage in green technology development. Companies that go green for the purpose of complying to regulations and fulfilling minimum customers’ demands can still embed green practices into their green value chain without compromising their performance.
Effect of technological innovation capabilities on the performance of selected manufacturing small and medium enterprises in Lagos State
Authors: Okpalaoka Chijindu , Ogunnaike Olaleke , Kalu Abigail , Yaya Temitope , Usendiah Edu , Emmanuel Ephraim 
Published: March 2022

Background: The issue of technological adoption and innovation in businesses as always been a big problem to organizations, especially manufacturing small and medium enterprises (SMEs) in Lagos state, Nigeria. The emphasis has therefore always been on how to adopt new technologies and innovations in improving and scaling profit or the profitability heights in businesses or SMEs. Methods: The main purpose of this research work is to have an understanding of the effect of technological innovation capabilities on the performance of selected manufacturing SMEs in Lagos State. This research work made use of a descriptive and causal research design as well as survey methods to examine whether technological learning capability affects the profitability of selected manufacturing SMEs in Lagos State and to determine whether resource allocation capability promotes sales growth amongst these manufacturing SMEs. Results: Findings showed that research and development capability have a significant impact on the value creation of selected manufacturing SMEs in Lagos. The research concluded that technological innovation capabilities have a positive impact on the performance of selected manufacturing SMEs in Lagos. In addition, the study recommended that manufacturing SMEs in Lagos, Nigeria, Africa and the globe should implement technological learning and the use of technology in their production process. Lastly, this research recommended that future research should focus on SMEs in other geopolitical zones or states.