bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual‐Loaded Liposomes Tagged with Hyaluronic Acid Have Synergistic Effects in Triple‐Negative Breast Cancer
Authors: Dong Shiyan , Bi Ye , Sun Xiangshi , Zhao Yarong , Sun Rongze , Hao Fei , Sun Yating , Wang Yifan , Li Xuefeng , Deng Weiye , Liu Xuan , Ha JongHoon , Teng Lirong , Gong Ping , Xie Jing , Kim Betty Y. S. , Yang Zhaogang , Jiang Wen , Teng Lesheng 
Published: March 2022

AbstractTriple‐negative breast cancer (TNBC) is the most lethal subtypes of breast cancer. Although chemotherapy is considered the most effective strategy for TNBC, most chemotherapeutics in current use are cytotoxic, meaning they target antiproliferative activity but do not inhibit tumor cell metastasis. Here, a TNBC‐specific targeted liposomal formulation of epalrestat (EPS) and doxorubicin (DOX) with synergistic effects on both tumor cell proliferation and metastasis is described. These liposomes are biocompatible and effectively target tumor cells owing to hyaluronic acid (HA) modification on their surface. This active targeting, mediated by CD44‐HA interaction, allows DOX and EPS to be delivered simultaneously to tumor cells in vivo, where they suppress not only TNBC tumor growth and the epithelial‐mesenchymal transition, but also cancer stem cells, which collectively suppress tumor growth and metastasis of TNBC and may also act to prevent relapse of TNBC.
Enhanced Near‐Field Radiative Heat Transfer between Graphene/hBN Systems
Authors: Lu Lu , Zhang Bo , Ou Han , Li Bowen , Zhou Kun , Song Jinlin , Luo Zixue , Cheng Qiang 
Published: March 2022

AbstractNear‐field radiative heat transfer (NFRHT) can exceed the blackbody radiation limit owing to the coupled evanescent waves, implying a significant potential for energy conversion and thermal management. Coupled surface plasmon polaritons (SPPs) and hyperbolic phonon polaritons (HPPs) with small ohmic losses enable a long propagation wavelength that is essential in NFRHT. However, so far, there still lacks knowledge about the experimental investigation of the coupling of SPPs and HPPs in terms of NFRHT. In this study, the NFRHT between graphene/hexagonal boron nitride (hBN) systems that can be readily transferred onto various substrates, with a gap space of ≈400 nm is measured. NFRHT enhancements in the order of three and six times higher than the blackbody limit for graphene/hBN heterostructures and graphene/hBN/graphene multilayers, respectively are demonstrated. In addition, the largest ever radiative heat flux using graphene/hBN/graphene multilayers under similar gap space of 400 nm is obtained. Consequently, analyzing the photon tunneling modes reveal that these phenomena are consequences of coupled SPPs of graphene and HPPs of hBN.
Vertical Crystal Plane Matching between AgZn3 (002) and Zn (002) Achieving a Dendrite‐Free Zinc Anode
Authors: Lu Hongfei , Jin Qianzheng , Jiang Xin , Dang Zhi‐Min , Zhang Di , Jin Yang 
Published: March 2022

AbstractMetallic zinc anodes in zinc‐ion batteries suffer from problematic Zn dendrite chemistry. Previous works have shown that preferred‐orientation crystal planes can help dendrite‐free metal anodes. This work reports a nanothickness (≈570 nm) AgZn3 coating to regulate the Zn growth. First, AgZn3@Zn anode avoids the problem, in Ag@Zn anode, that the rate of electrochemical Ag‐Zn alloying is slower than that of Zn dendrites growth. Batteries life increased from 112 h (pure Zn) and 932 h (Ag@Zn) to 1360 h (AgZn3@Zn) at 2 mA cm−2 and 1 mAh cm−2. Then, plasma sputtering can remove nonconductive ZnO and improve Zn‐ion affinity, which brings a longer life for AuZn3@Zn (423 h), CuZn3@Zn (385 h), and AgZn3@Zn (1150 h) than pure Zn (93 h) at 1 mAh cm−2. More importantly, AgZn3 (002) has a high matching with the Zn (002), which can guide ordered Zn epitaxial deposition, thereby achieving dense and dendrite‐free Zn growth. This work clearly captures the fascinating structure of the densely stacked Zn layers on the AgZn3 layer. This strategy not only improves the performance of zinc‐ion batteries greatly but will also help one understand the matching mechanism of the (002) vertical crystal plane.
Realizing Simultaneous Detrimental Reactions Suppression and Multiple Benefits Generation from Nickel Doping toward Improved Protonic Ceramic Fuel Cell Performance
Authors: Song Yufei , Chen Jiaming , Yang Meiting , Xu Meigui , Liu Dongliang , Liang Mingzhuang , Wang Yuhao , Ran Ran , Wang Wei , Ciucci Francesco , Shao Zongping 
Published: March 2022

AbstractAnode‐supported protonic ceramic fuel cells (PCFCs) are highly promising and efficient energy conversion systems. However, several challenges need to be overcome before these systems are used more widely, including the poor sintering of recently developed proton‐conducting oxides and the decreased proton conductivity due to detrimental reactions between the nickel from anode and the electrolyte occurring during high‐temperature co‐sintering. Herein, a Ni doping strategy to increase the electrolyte sintering, suppress the detrimental phase reactions, and generate stable Ni nanoparticles for enhanced performance is proposed. A nickel‐doped perovskite oxide is developed with the nominal composition of Ba(Zr0.1Ce0.7Y0.1Yb0.1)0.95Ni0.05O3−δ. Acting as a sintering aid, such a small amount of nickel effectively improves the sintering of the electrolyte. Concomitantly, reactions between nickel and the Ni‐doped ceramic phase are suppressed, turning detrimental phase reactions into benefits. The nickel doping further promotes the formation of Ni nanoparticles, which enhance the electrocatalytic activity of the anode toward the hydrogen oxidation reaction and improve the charge transfer across the anode–electrolyte interface. As a result, highly efficient PCFCs are developed. The innovative anode developed in this work also shows favorable activity toward ammonia decomposition, making it highly promising for use in direct ammonia fuel cells.
Supramolecular Core–Shell Nanoassemblies with Tumor Microenvironment‐Triggered Size and Structure Switch for Improved Photothermal Therapy
Authors: Wang Ziyao , Wang Yanqiu , Sun Xiaohuan , Zhou Jinfeng , Chen Xiaolin , Xi Juqun , Fan Lei , Han Jie , Guo Rong 
Published: March 2022

AbstractPhotothermal therapy (PTT) is demonstrated to be an effective methodology for cancer treatment. However, the relatively low photothermal conversion efficiency, limited tumor accumulation, and penetration still remain to be challenging issues that hinder the clinical application of PTT. Herein, the core–shell hierarchical nanostructures induced by host–guest interaction between water‐soluble pillar[5]arene (WP5) and polyethylene glycol‐modified aniline tetramer (TAPEG) are constructed. The pH‐responsive performance endows the core–shell nanostructures with size switchable property, with an average diameter of 200 nm in the neutral pH and 60 nm in the acidic microenvironment, which facilitates not only tumor accumulation but also tumor penetration. Moreover, the structure switch of WP5⊃TAPEG under acidic microenvironment and the dual mechanism regulated extending of п conjugate, inclusion in the hydrophobic cavity of WP5 and the dense distribution in the core–shell structured assemblies, dramatically enhance the absorption in the near‐infrared‐II region and, further, the photothermal conversion efficiency (60.2%). The as‐designed intelligent nanoplatform is demonstrated for improved antitumor efficacy via PTT.
2D Ultrawide Bandgap Semiconductors: Odyssey and Challenges
Authors: Yang Wen , Xin Kaiyao , Yang Juehan , Xu Qun , Shan Chongxin , Wei Zhongming 
Published: March 2022

Abstract2D ultrawide bandgap (UWBG) semiconductors have aroused increasing interest in the field of high‐power transparent electronic devices, deep‐ultraviolet photodetectors, flexible electronic skins, and energy‐efficient displays, owing to their intriguing physical properties. Compared with dominant narrow bandgap semiconductor material families, 2D UWBG semiconductors are less investigated but stand out because of their propensity for high optical transparency, tunable electrical conductivity, high mobility, and ultrahigh gate dielectrics. At the current stage of research, the most intensively investigated 2D UWBG semiconductors are metal oxides, metal chalcogenides, metal halides, and metal nitrides. This paper provides an up‐to‐date review of recent research progress on new 2D UWBG semiconductor materials and novel physical properties. The widespread applications, i.e., transistors, photodetector, touch screen, and inverter are summarized, which employ 2D UWBG semiconductors as either a passive or active layer. Finally, the existing challenges and opportunities of the enticing class of 2D UWBG semiconductors are highlighted.
Additive Manufacturing in Atomic Layer Processing Mode
Authors: Kundrata Ivan , Barr Maïssa K. S. , Tymek Sarah , Döhler Dirk , Hudec Boris , Brüner Philipp , Vanko Gabriel , Precner Marian , Yokosawa Tadahiro , Spiecker Erdmann , Plakhotnyuk Maksym , Fröhlich Karol , Bachmann Julien 
Published: March 2022

AbstractAdditive manufacturing (3D printing) has not been applicable to micro‐ and nanoscale engineering due to the limited resolution. Atomic layer deposition (ALD) is a technique for coating large areas with atomic thickness resolution based on tailored surface chemical reactions. Thus, combining the principles of additive manufacturing with ALD could open up a completely new field of manufacturing. Indeed, it is shown that a spatially localized delivery of ALD precursors can generate materials patterns. In this “atomic‐layer additive manufacturing” (ALAM), the vertical resolution of the solid structure deposited is about 0.1 nm, whereas the lateral resolution is defined by the microfluidic gas delivery. The ALAM principle is demonstrated by generating lines and patterns of pure, crystalline TiO2 and Pt on planar substrates and conformal coatings of 3D nanostructures. The functional quality of ALAM patterns is exemplified with temperature sensors, which achieve a performance similar to the industry standard. This general method of multimaterial direct patterning is much simpler than standard multistep lithographic microfabrication. It offers process flexibility, saves processing time, investment, materials, waste, and energy. It is envisioned that together with etching, doping, and cleaning performed in a similar local manner, ALAM will create the “atomic‐layer advanced manufacturing” family of techniques.
Nanofibers Comprising Interconnected Chain‐Like Hollow N‐Doped C Nanocages as 3D Free‐Standing Cathodes for Li–S Batteries with Super‐High Sulfur Content and Lean Electrolyte/Sulfur Ratio
Authors: Saroha Rakesh , Cho Jung Sang 
Published: March 2022

AbstractThe development of a suitable cathode host that withstands high sulfur content/loading and low electrolyte/sulfur (E/S) ratio is particularly important for practically sustainable Li–S batteries. Herein, a facile approach is utilized to prepare free‐standing 3D cathode substrates comprising nitrogen‐doped carbon (N‐C) scaffold and metal–organic framework derived interconnected chain‐like hollow N‐C nanocages, forming a highly porous N‐C nanofiber (HP‐N‐CNF) framework. The N‐C skeleton provides highly conductive pathways for fast lithium ion/electron diffusion. The hollow interconnected N‐C nanocages not only offer enough space to absorb a high volume of active material but also effectively channelize severe volume stress during the electrochemical performance. The Li–S cell utilizing HP‐N‐CNF as cathode host displays exceptional battery parameters with high effective sulfur content (83.2 wt%), ultrahigh sulfur loading (14.3 mg cm–2), and low E/S ratio (6.8 μL mg–1). The Li–S cell exhibits a maximum areal capacity of 12.2 mAh cm–2 which stabilizes at ≈5.5 mAh cm–2 after the 130th cycle at 0.05 C‐rate and is well above the theoretical threshold. Therefore, the proposed unique nanostructure synthesis approach would open new frontiers for developing more realistic and sustainable host materials with feasible battery parameters for various energy storage applications.
Two Birds with One Stone: Using Indium Oxide Surficial Modification to Tune Inner Helmholtz Plane and Regulate Nucleation for Dendrite‐free Lithium Anode
Authors: Chen Yaqi , Xu Xieyu , Gao Leiwen , Yu Guangyong , Kapitanova Olesya O. , Xiong Shizhao , Volkov Valentyn S. , Song Zhongxiao , Liu Yangyang 
Published: March 2022

AbstractLithium metal has been considered as the most promising anode material due to its distinguished specific capacity of 3860 mAh g–1 and the lowest reduction potential of ‐3.04 V versus the Standard Hydrogen Electrode. However, the practicalization of Li‐metal batteries (LMBs) is still challenged by the dendritic growth of Li during cycling, which is governed by the surface properties of the electrodepositing substrate. Herein, a surface modification with indium oxide on the copper current collector via magnetron sputtering, which can be spontaneously lithiated to form a composite of lithium indium oxide and Li‐In alloy, is proposed. Thus, the growth of Li dendrites is effectively suppressed via regulating the inner Helmholtz plane modified with LiInO2 to foster the desolvation of Li‐ion and induce the nucleation of Li‐metal in two‐dimensions through electro‐crystallization with Li‐In alloy. Using the In2O3 modification, the Li‐metal anode exhibits outstanding cyclic stability, and LMBs with lithium cobalt oxide cathode present excellent capacity retention (above 80% over 600 cycles). Enlightening, the scalable magnetron sputtering method reported here paves a novel way to accelerate the practical application of the Li anode in LMBs to pursue higher energy density.
Montage von Stahlgroßbrücken nach 1975 (Teil 5) – Montage im Stahlbrückenbau
Authors: Pelke Eberhard , Kurrer Karl‐Eugen 
Published: March 2022

AbstractDie Formierung der Montage zur Leitdisziplin im bundesdeutschen Stahlgroßbrückenbau der 1960er‐Jahre wurde in Teil 4 dieser Aufsatzserie exemplarisch aufgezeigt. Mit dem schrittweisen Einzug der Automation in die Stahlbaufertigung seit den späten 1970er‐Jahren, den neuen Möglichkeiten des Mobilkraneinsatzes bei der Montage von Stahlgroßbrücken seit den 1980er‐Jahren, der zielbewussten Nutzung wissenschaftlicher Erkenntnisse der Logistik für den Stahlbau und der durch das Internet vorangetriebenen digitalen Transformation des technischen Schaffens nach der Jahrtausendwende ändern sich Struktur und Einbettung der Montage in den komplexen Zusammenhang des systemintegrierten Stahlbaus grundlegend.
Monitoring der Theodor‐Heuss‐Brücke – Teil 2 – Modellbildung und ‐verbesserung für messwertgestützte Ermüdungsnachweise
Authors: Schartner Maria , Sanio David , Klinge Jan , Schmitz Andreas , Herzberg Theres , Störmer Manuela 
Published: March 2022

AbstractAufgrund rechnerischer Defizite in der Ermüdungstragfähigkeit der orthotropen Fahrbahnplatte wurde an der Theodor‐Heuss‐Brücke ein Monitoringsystem installiert, um Dehnungen an maßgebenden Stellen für ein Jahr zu messen. In Teil 1 dieses Beitrags wurden das Monitoringsystem und Erkenntnisse zum Tragverhalten anhand der Messdaten beschrieben. Dieser zweite Teil schließt mit messwertgestützten Ermüdungsnachweisen und der Lebensdauerprognose an. Grundlage der Auswertungen ist ein numerisches Berechnungsmodell, welches anhand von zwei Probebelastungen in Sommer und Winter kalibriert wird. Unter Berücksichtigung verschiedener Laststellungen werden Übertragungsfaktoren abgeleitet, die die Differenz zwischen Messstelle und maßgebender Nachweisstelle kompensieren. Damit werden die gemessenen Schwingbreitenhistogramme in maßgebende Belastungsspektren transformiert, mit denen schließlich die Lebensdauerprognose erfolgt. Die Auswertungen zeigen, dass für die meisten Bauteile weitere Tragreserven vorhanden sind und eine deutliche Verbesserung gegenüber der Nachrechnung erreicht wird. Einzig die Ecken der Querträgerausnehmungen (Querträgerstegzähne) weisen deutliche Defizite auf, die sich auch im vorhandenen Rissbild widerspiegeln. Über die Zukunft der Theodor‐Heuss‐Brücke, die von weiteren Faktoren abhängt, wird derzeit entschieden.
Weiter so – ausgeschlossen – Die Stahlbaufertigung muss klimaneutral werden
Authors: Hahner Bernhard 
Published: March 2022

AbstractAuch mittelständische Stahlbauunternehmer und Arbeitgeber haben eine persönliche Verantwortung, ihre Unternehmen und ihre Branche im Interesse nachfolgender Generationen nachhaltig aufzustellen. In einem persönlichen Beitrag wird erläutert, wie der Unternehmer Bernhard Hahner innerhalb der für sein Unternehmen herausgearbeiteten sechs Handlungsbereiche agiert, um dem Ziel „Klimaneutraler Stahlbau“ kontinuierlich näher zu kommen. Der Beitrag beleuchtet die Einflussmöglichkeiten auf Lieferanten und Dienstleister, stellt die Entwicklung eigener nachhaltiger Stahlbauprodukte vor und erläutert im Bereich Stahlbaufertigung bereits umgesetzte ebenso wie geplante Veränderungen und Verbesserungen an Gebäuden und Anlagen. Thema ist auch die Kooperation mit Kunden, die sowohl nachhaltige Produktion einfordern als auch selbst durch intensive Zusammenarbeit in der Planungsphase Projekte vor Produktionsbeginn optimieren können. Dabei wird auch auf Trends wie Urban Mining oder Building Information Modeling eingegangen. Fazit der gegenwärtigen Situation: Tiefgreifende Veränderungen sind unumgänglich, sie sind aber auch realistisch machbar.
Atacamallium minutiflorum (Amaryllidaceae, Allioideae), new genus and species from the coastal desert of northern Chile
Authors: García Nicolás , Sassone Agostina B. , Pinto Raquel , Román María José 
Published: March 2022

AbstractAtacamallium, a new genus in Amaryllidaceae‐Allioideae‐Leucocoryneae, is introduced with a description of its type Atacamallium minutiflorum, endemic to the coastal Atacama Desert of northern Chile. Phylogenetic analyses of DNA sequences, along with morphological characters and its distribution pattern, support the new genus and place it as a putative sister to Leucocoryne, which is readily distinguished from Atacamallium by its floral morphology. Atacamallium minutiflorum differs from other species of Leucocoryneae by its overall smaller flowers, tepals fused only at the base, six stamens in a single series, and trifid stigma. A morphological description, a distribution map, an illustration, and the assessment of the conservation status of the new species, besides an updated key to the genera of Leucocoryneae, are provided. Additional data from multiple single‐copy nuclear genes are needed to clarify the relationships within the tribe.
Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice
Authors: Fan Yingying , Wang Jian , Feng Zhihui , Cao Ke , Liu Jiankang , Xu Hao 
Published: March 2022

AbstractBackgroundBackground: Acute lung injury (ALI) is one kind of frequently occurred emergency in Intensive Care Unite with a high mortality. The underlying causes are uncontrolled inflammatory reactions and intractable hypoxemia, which are difficult to control and improve. In the past 10 years, gas medical studies have found that both hydrogen molecules and oxygen molecules have protective effects on acute lung injury by improving inflammatory reactions and hypoxia, respectively. Oxygen is an oxidant and hydrogen is an antioxidant. In this study, we investigated the combined effect of above two‐gas molecular on lipopolysaccharide (LPS) ‐induced acute lung injury.MethodsTo clarify whether the combination of hydrogen and oxygen could increase or cancel out the protective effect, an ALI mice model induced by intraperitoneal injection of LPS was established, and the degree of lung tissue and mitochondria damage was evaluated based on the pathological sections, inflammatory factors, wet–dry ratio, bronchoalveolar lavage fluid (BALF). Immunohistochemistry, electron microscopy, western blotting and other detection methods also used to evaluate the therapeutic effect on acute lung injury model.ResultsWe observed that the combined protective effect of hydrogen and oxygen was superior to their respective protective effects, and the specific molecular mechanisms of the two therapies might be different.ConclusionHydrogen plays a more important role in the inflammatory and anti‐apoptosis mechanisms, while oxygen improves hypoxia of the body, and thus, its molecular mechanism may be closely associated to the hypoxia pathways.
Clinical signs, MRI findings and long‐term outcomes of foraminal and far lateral thoracolumbar intervertebral disc herniations in dogs
Authors: Silva Sara , Guevar Julien , José‐López Roberto , De Decker Steven , Brocal Josep , de la Fuente Cristian , Durand Alexane , Forterre Franck , Olby Natasha , Gutierrez‐Quintana Rodrigo 
Published: March 2022

AbstractBackgroundAs they have been seldomly described in the veterinary literature, the aims of this retrospective study were to describe the clinical presentation, MRI findings and long‐term outcome after medical or surgical treatment of dogs presenting with foraminal and far lateral thoracolumbar intervertebral disc herniations.MethodsRetrospective multicentre study of dogs diagnosed with foraminal and far lateral thoracolumbar intervertebral disc herniations between 2009 and 2020 in seven referral hospitals.ResultsThirty‐seven dogs were included. Dachshunds and mixed breeds were most affected. Median age at presentation and duration of clinical signs were 6 years and 14 days, respectively. Pain was the most frequent clinical finding (92%), particularly on spinal palpation and/or hip manipulation, followed by pelvic limb lameness (71%). Eighty‐seven percent of herniations occurred at L5‐L6 or L6‐L7. A good to excellent outcome was seen in 95% of surgically and 90% of medically treated dogs.ConclusionAlthough much less frequently recognised than herniation affecting the vertebral canal, foraminal and far lateral thoracolumbar intervertebral disc herniations should be considered in the differential diagnosis list of chondrodystrophic dogs presenting with pain and pelvic limb lameness. Most dogs had a good to excellent outcome following medical or surgical treatment.
Anaesthetic management in adult fallow deer undergoing orthopaedic surgery
Authors: Mansour Christelle , Hout Nermine El , Hassoun Roy 
Published: March 2022

AbstractBambi, an adult female captive fallow deer (Dama dama), was presented to Beirut Pet Hospital in March 2021 for left metacarpal fracture. Bambi appeared to be exceptionally tolerant to physical restraint, so examination and preparation were performed carefully in a quiet room to avoid stress‐induced hyperthermia. Bambi was injected with butorphanol–medetomidine combination intravenously, followed by induction with diazepam and ketamine. Surgical anaesthesia and analgesia were maintained under isoflurane and a continuous rate infusion of fentanyl. Fracture reduction was employed followed by internal fixation, and the anaesthetic protocol was effective at maintaining deep anaesthesia and controlling pain allowing a good recovery. Limited data are found in the literature describing deer species undergoing orthopaedic surgeries under general anaesthesia. This case report represents an effective anaesthetic protocol that could be considered in cervids admitted to the veterinary clinics for orthopaedic surgeries.