bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protection against rotenone-induced animal model of Parkinson’s disease: Electrophysiological, behavioral and histological study
Authors: Darbinyan Lilit , Hambardzumyan Lilia , Manukyan Larisa , Sarkisian Vaghinak 
Published: February 2022

Parkinson's disease (PD) is an age-related neurodegenerative disease characterized clinically as a movement disorder. A hallmark feature of PD is the degeneration of the dopamine neurons in the substantia nigra pars compacta and the consequent striatal dopamine deficiency. The lack of dopamine causes the primary symptoms of PD- tremor, slowness of movement, muscle stiffness and balance problems. Research is devoted to the study of systemic compensatory reactions of the rat's brain developing in response to rotenone-induced animal model of PD under the conditions of neuroprotective intervention of Curcumin. This has raising expectations for the development of new neuroprotective therapies for the prevention of PD. Male albino rats were treated with rotenone injections (2.5 mg/ml intraperitoneally) for 21 days.We examined the effects of neuroprotector curcumin (200 mg/kg) on behavior and the electrical activity of hippocampus neurons measured in response to high frequency stimulation (HFS) of entorhinal cortex (EC). In the hippocampus, the excitatory and inhibitory synapses between EC and CA3 pyramidal cells expresses robust forms of short-term plasticity, such as frequency facilitation (post-tetanic potentiation – PTP) and depression (post-tetanic depression – PTD). Motor activity was assessed by cylinder test. The results showed that Rotenone causes significant reduction of neuronal activity, whereas curcumin can improve the motor impairments and electrophysiological parameters and may be beneficial in the treatment of PD. Curcumin significantly prevented rotenone-induced impairment of hippocampal synaptic plasticity, which is likely mediated via dysfunction of mitochondrial complex I. It alleviated the deficits behavior in rats as the rearing frequencies of animals were enhanced.
Keywords: Parkinson's disease, rotenone-induced animal model, electrophysiological parameters, deficits behavior.
Fear of childbirth and high stress are predictive of psychological disturbances during pregnancy
Authors: Guerroumi Maroua , Aquil Amina , El Kherchi Ouassil , Elgot Abdeljalil 
Published: February 2022

Mental health disorders, particularly psychological distress in women in the last trimester of pregnancy, are generally underestimated and under-diagnosed by health professionals. Thus, this quantitative descriptive study has the following main objectives: a) to evaluate depressive and anxiety disorders during the third trimester of pregnancy, b) to identify certain risk factors of these mental problems and, c) to determine the impact of these disorders on the quality of life of pregnant women.
To achieve these objectives, a validated questionnaire translated into dialectal Arabic was used with 178 pregnant women in the third trimester of their pregnancy, the majority of whom were in the last month of gestation. Our study was conducted in the Marrakech-Safi region in two urban health centres: the Oasis, Youssef Ben Tachfine and a delivery unit.
The results we obtained in this work showed that anxiety is proven in 60.11% of pregnant women and only 44.38% are diagnosed as depressed, while a percentage of about 79.21% of parturients showed that they suffer from the anxiety-depression syndrome. High stress levels, body dissatisfaction caused by pregnancy and even fear of childbirth are preliminary risk factors for anxiety and depression in the last trimester of pregnancy, not to mention the the relieving effect of self-esteem against these mental disorders.
As a result of this work, and in order to combat these health problems throughout pregnancy, it has been necessary to integrate preventive and sometimes curative measures in the prenatal medical follow-up.
Keywords: Mental Health, Anxiety, depression, Quality of life
Protective effect of bacterial melanin in the substantia nigra in a rat model of Parkinson's disease
Authors: Danielyan M. H. , Nebogova K.A. , Khachatryan V.P. , Poghosyan M.V. , Karapetyan K.V. 
Published: February 2022

The major cause of Parkinson's disease is progressive disturbance of dopaminergic neurons of the substantia nigra, as well as their nerve endings located in the striatum. Therefore, therapy aimed at slowing the death of dopaminergic neurons can be effective. In recent decades, various types of neuroprotective agents have been successfully used in the treatment of neurodegenerative diseases, after which the restoration of structural disfunctions of the CNS is accelerated. In the present study, we used bacterial melanin, the therapeutic effect of which is due to the improvement of the trophic effects of the brain tissue, inhibition of the inflammatory process and gliosis. The comparative study of morphological and functional state of the substantia nigra pars compacta in a rotenone model of Parkinson's disease and combined with introduction of bacterial melanin was carried out. For morphological and histochemical study, the method of detecting the activity of Ca2 + - dependent acid phosphatase was used. The analysis of the data obtained showed that during rotenone intoxication, neuronal death and substantia nigra depigmentation are observed, as well as sharp morphological changes in intracellular structures occur, which indicates gross metabolic and morphological disorders. With the introduction of bacterial melanin, there is a tendency to preserve the normal morphological picture of the neurons of the substantia nigra pars compacta, in comparison with the Parkinson's disease model. Thus, bacterial melanin acts as a neuroprotective agent and has a supportive role in Parkinson's disease.
Keywords: bacterial melanin, Parkinson's Disease, substantia nigra
A new synesthesia-based approach for AI in healthcare
Authors: EL HANDRI Kaoutar , EL AHRACH Sanae , TOUIL Mohamed 
Published: February 2022

Recent changes in all fields have rapidly taken place, causing radical changes in various spheres of our society. They have particularly affected artificial intelligence, whose priority is to adopt several human qualities to adapt to the changes.
AI algorithms inspired by human characteristics and behavioral patterns vary with the paradigms of big data for satisfying individual requirements and treating the problems of the development of creative reasoning. Therefore, getting inspired by highly complex neurological phenomena and behaviors, whether typical or atypical such as synesthesia, is recommended in learning. The evolution of science confirms the theory and methodology of synesthesia. Therefore, it has been focused on the individual's problem identifying different neuroscientific characteristics and explaining their specific potential in developing creativity. Inspired by this, our work focuses on understanding the phenomenon of sound synesthesia in creative thinking, which is a kind of additional mechanism for the perception and development of skills and abilities to analyze the relationship between sound and color in the text.
The approach based on the system-activity correlation was applied in work, ensuring the research's integrity, complexity, structure, and purpose. Finally, we aim to find the symbolism of sounds that supports the semantic core of the meaning of linguistic signs.
The NLP (Natural Language Processing) is producing new based models while developing the creative thinking of machines to evolve that of people, aiming to help them reach the rapid changes of the modern world.
Key words: synesthesia, artificial intelligence, algorithms, neurodiverse, learning, correlation.
Radiation dose and image quality in abdominal CT: Phantom Study
Authors: EL MANSOURI M'hamed , CHOUKRI Abdelmajid , TALBI Mohammed , KHALLOUKI Othmane 
Published: February 2022

The purpose of this study was to evaluate and compare the effect of acquisition parameters of the abdominal computed tomography protocol on image quality and dose quantities, including contrast-to-noise ratio (CNR), noise, spatial resolution (SR) as well as volumetric computed tomography dose index (CTDIv).
The measurements have been done on a HITACHI 16-slice scanner using two phantoms (PMMA and Catphan 500), two tube voltages of 120KVp and 100KVp have been analyzed while varying the tube current settings from 155 to 300 (mAs) in order to measure the abdominal image quality quantities and dose (CTDIv).
The scanning at 100KVp compared to 120KVp has resulted in a dose reduction up to 38% at mAs ranging from 100 to 300, a decrease in CNR of 28%, a slight decrease in spatial resolution accompanied with an increase in noise.
This study has shown that despite the increase in noise at low tube voltages, it is possible to reduce the dose without affecting the quantities of spatial resolution and the contrast/noise ratio by lowering the tube voltage from 120KVp to 100KVp.
Keywords: Abdominal CT; CTDIv; Image Quality; Phantom.
Molecular diagnosis of Duchene Muscular dystrophy
Authors: Berrada Sarah , Tazzite Amal , Dehbi Hind 
Published: February 2022

Dystrophinopathies are the most common forms of muscular dystrophy in childhood, characterize by a progressive muscle weakness. Mutations in the DMD gene result in Duchenne Muscular Dystrophy (DMD) or Becker Muscular Dystrophy (BMD), inherited in X-linked recessive mode with a frequency of 1 in 3500 live born males. The present retrospective study aims to describe the mutation spectrum of DMD gene observed in 19 boys with muscular dystrophy without any clinical or familial information addressed to our laboratory between 2016 and 2020. Mutation analysis was performed by PCR multiplex using a primer set of Chamberlain and Beggs. DNA was extracted from peripheral blood and PCR products were separated on 1% agarose gel and detected in U.V light after ethidium bromide staining. The DMD gene is the largest human gene (2.4Mb) on Xp2. It consists of 79 exons encoding for dystrophin. Deletions were observed in 60% of patients, especially in the exons 3–7 and 44–55. To discern between the DMD and DMS diseases we can use a clinical approach or immunohistochemistry techniques. However, the protein-based strategy followed by molecular analysis is probably the most efficient way to approach diagnosis and to propose a correct genetic counselling.
Keywords: Dystrophinopathies, Polymerase chain reaction, Duchene Muscular Dystrophy, Becker Muscular Dystrophy.
Assessment of the impact of anxiety and depression disorders on the quality of life of hemodialysis patients
Authors: Touil Driss , Ahami Ahmed .O.T 
Published: February 2022

Patients with high anxiety or depression express low physical and mental quality of life, more symptoms and problems related to the disease, the effects of kidney disease more present in their daily lives and a greater sense of burden. This relationship between anxiety/depression and quality of life led us to conduct a study to identify the impact of anxiety and depression disorders on quality of life in haemodialysis patients. This cross-sectional descriptive study was conducted on a sample of 70 patients in the dialysis unit in Regional hospital center of Kenitra. Using psychiatric assessment scales: The Hospital Anxiety and Depression Scale to assess anxiety and depression and the KDQOL scale to assess quality of life, the results obtained are as follows: The mean age was 51.66±15.96 years. The average length of time on haemodialysis was 5.20±3.23 years. The study found a significant correlation between the patient's "effect of kidney disease on daily life" domain and anxiety, and a significant correlation of depression with the patient's "physical and psychological health", "kidney disease symptoms" and "effect of kidney disease on daily life" domains.This impact of anxiety and depression on quality of life makes the prevention of the risks of anxiety and depression disorders a necessity for improving the quality of life of haemodialysis patients.
Keywords: hemodialysis -anxiety -depression -quality of life -Kenitra
Neurological manifestations in Tuberous Sclerosis Complex
Authors: Bouzroud Wafaa , Berrada Sarah , Ibenbrahim Youssra , Maarouf Fatima , Tazzite Amal , Dehbi Hind 
Published: February 2022

Tuberous Sclerosis Complex (TSC) is a rare multisystemic neurocutanous autosomal dominant syndrome. The cause of this disorder is a germinal mutation in TSC1 or TSC2 genes. Here, we report a case of a patient presenting tuberous sclerosis complex with TSC2 gene mutation. Our patient is aged 2 years and 6 months old, youngest of two siblings from a non-related marriage. The symptoms are neonatal hypotonia, epilepsy, psychomotor retardation, intellectual deficiency, dolichocephaly, above-average height, facial dysmorphia, and diffuse achromic spots on the chest and abdomen. The family survey found multiple siblings with various symptoms such as bony deformities, epilepsy, language delay, partial deafness, congenital renal malformation, and intellectual disability. The patient's brain MRI showed areas of cortico-subcortical hypodensity and subependymal nodules. The exome sequencing has detected a probably pathogenic heterozygous nonsense variant in the TSC2 gene: NM_000548.3: c.965C>A p.(ser322*). The variant identification was not performed in the parents due to lack of resources. TSC1 and TSC2 genes encode for hamartin-tuberin complex. Mutations in these genes cause hyperactivation of the mTOR pathway leading to the tumor development in several organs including the brain. The neurological manifestations of TSC can be epilepsy, intellectual deficiency, autism and behavioral disorders. The epilepsy is considered the main neurological symptom found in 70-90% of cases. Moreover, mutations in the TSC2 gene lead to severe epilepsy compared to TSC1 mutation. The TSC is a disorder with an important neurological component. Investigations of epilepsy, brain MRI and genetic analysis may play an essential role in TSC diagnosis.
Keywords: Tuberous Sclerosis Complex, Neurology, Genetic mutation, TSC2.
Fragile X Syndrome: role of the FMR1 gene in neurodevelopmental disorders
Authors: Ibenbrahim Youssra , Bouzroud Wafaa , Berrada Sarah , Maarouf Fatima , Tazzite Amal , Dehbi Hind 
Published: February 2022

Fragile X syndrome (FXS) is a multisystem disorder characterized by a large clinical spectrum including neuropsychological and behavioral disturbances such as intellectual deficiency (ID), global developmental delay, seizures and autism spectrum disorders (ASD). This syndrome is the result of a full mutation of the FMR1 gene. Here, we report the case of two patients with FXS.
Patient 1 is a 9-years-old child with ID, psychomotor developmental delay and facial dysmorphia. The family survey found a history of school failure in maternal uncle and cousin. FMR1 gene analysis identified pre-mutation and full mutation.
Patient 2, aged 10, presents ID, epilepsy, absence of language, psychomotor retardation, behavioral disorder and facial dysmorphia. The brothers and three maternal cousins have ID. FMR1 gene analysis revealed full mutation.
The FMR1 gene, located on Xq27.3, is involved in the development and maintenance of neural circuits essential for cognitive functions. FMR1 encodes the fragile X mental retardation protein (FMRP). This protein has a local role in synaptic plasticity, dendrite and axon development, and underlying learning and memory. The trinucleotide repeat expansions inactivate the FMR1 gene leading to the absence of FMRP and RNA/proteins dysregulation that causes alterations in synaptic connectivity clearly observed in FXS patient brains and a decrease in the number of dendrites and spines. FXS research emerged as a model of translational neuroscience. Therefore, deeper knowledge of FMRP functions would lead to rational therapeutic approaches. Furthermore, understanding the role of FMRP at synapses offers hope for the treatment of other ASD affecting learning and behavior.
Keywords: X Fragile Syndrome, FMR1, FMRP, Neurodevelopmental disorders.
Particle emissions from a modern heavy-duty diesel engine as ice nuclei in immersion freezing mode: a laboratory study on fossil and renewable fuels
Authors: Korhonen Kimmo , Kristensen Thomas Bjerring , Falk John , Malmborg Vilhelm B. , Eriksson Axel , Gren Louise , Novakovic Maja , Shamun Sam , Karjalainen Panu , Markkula Lassi , Pagels Joakim , Svenningsson Birgitta , Tunér Martin , Komppula Mika , Laaksonen Ari , Virtanen Annele 
Published: February 2022

Abstract. We studied ice-nucleating abilities of particulate
emissions from a modern heavy-duty diesel engine using three different types
of fuel. The polydisperse particle emissions were sampled during engine
operation and introduced to a continuous-flow diffusion chamber (CFDC)
instrument at a constant relative humidity RHwater=110 %, while
the temperature was ramped between −43 and −32 ∘C (T scan). The
tested fuels were EN 590 compliant low-sulfur fossil diesel, hydrotreated
vegetable oil (HVO), and rapeseed methyl ester (RME); all were tested without
blending. Sampling was carried out at different stages in the engine exhaust
aftertreatment system, with and without simulated atmospheric processing
using an oxidation flow reactor. In addition to ice nucleation experiments,
we used supportive instrumentation to characterize the emitted particles for
their physicochemical properties and presented six parameters. We found that
the studied emissions contained no significant concentrations of ice-nucleating particles likely to be of atmospheric relevance. The substitution
of fossil diesel with renewable fuels, using different emission
aftertreatment systems such as a diesel oxidation catalyst, and
photochemical aging of total exhaust had only minor effect on their
ice-nucleating abilities.
Abordagens cognitivistas na aquisição da língua escrita: revisitando O mapa do pezinho
Authors: Silva Leosmar Aparecido da , Cerqueira Mirian Santos de , Rauber André Luiz 
Published: February 2022

Este estudo tem como objetivo revisitar, teórica e metodologicamente, o artigo intitulado “Aquisição da escrita: a construção textual em O mapa do pezinho”, de Rauber (2008). Para isso, toma como ponto fundamental as abordagens cognitivistas para o estudo da aquisição da língua escrita, tanto numa perspectiva baseada no uso (funcionalista) quanto noutra de viés mentalista (gerativista). A metodologia utilizada para a realização deste trabalho concentra-se na análise qualitativa de um texto produzido por uma criança em idade escolar. Os resultados mostraram que, independentemente das divergências quanto ao processo de desenvolvimento da linguagem escrita, as ciências cognitivas ancoradas no gerativismo e no funcionalismo têm muito a contribuir para os estudos sobre a aprendizagem da escrita.
Captación de energía limpia para el suministro eléctrico en la UNTELS
Authors: Vilchez Ochoa Guillermo Lorenzo 
Published: February 2022

La finalidad de este proyecto es poder brindar a la Universidad Nacional Tecnológica de Lima Sur (UNTELS) dos fuentes de energía que puedan abastecer diversas actividades. Estas fuentes serán de energía limpia y de energía convencional. La fuente de energía renovable estará compuesta por un generador fotovoltaico y un inversor; este último trabajará de manera automática para interrumpir el uso de la energía convencional cuando se esté suministrando energía limpia. Así, este trabajo de investigación pretende evaluar el dimensionamiento y la viabilidad económica para poder suministrar energía limpia a la UNTELS. Para ello, se realizó la cuantificación de la energía limpia para las actividades en la UNTELS, se estimó la viabilidad del proyecto usando indicadores económicos y se analizó la reducción de dióxido de carbono con el generador fotovoltaico. Con base en el desarrollo del proyecto, se puede afirmar que tener un sistema híbrido que aporte tanto energía convencional como energía limpia si es viable desde el punto de vista técnico y económico.
Perfiles asociados al nivel de ingreso laboral de los egresados universitarios – análisis multivariable de la encuesta nacional INEI 2014
Authors: PELAEZ OSORIO MARIO ROGELIO , MANCO CAYCHO MYRNA 
Published: February 2022

Se realizaron los análisis de construcción de conglomerados, de correspondencias múltiples y de tablas cruzadas múltiples sobre la Encuesta Nacional a Egresados Universitarios del INEI. El objetivo fue relacionar las condiciones educativas con los niveles de ingreso laboral de profesionales universitarios. Los egresados se agruparon en 2 niveles socioeconómicos familiares (bajo y medio-alto) y en 3 categorías de ingreso laboral (bajo, medio y alto). El nivel socioeconómico de la familia del egresado se utilizó como variable de control y determina de manera significativa los niveles de ingreso laboral de los egresados universitarios. El 73% del total de egresados conservan el mismo nivel económico de su familia. Se encontraron los perfiles educativos para cada uno de los 6 grupos resultantes. En el estrato socioeconómico bajo, el perfil del graduado universitario que logra obtener ingresos laborales medios o altos se determina por la carrera que eligió estudiar (ingeniería, tecnológica o de salud), pertenece al cuadro de méritos, estudia postgrado, ya tiene título profesional y que el primer empleo que logró se corresponde con su nivel de calificación. En el estrato socioeconómico alto, el perfil del graduado que logra obtener ingresos laborales altos, es muy similar al perfil del estrato bajo; sin embargo intervienen además la calidad excelente de infraestructura y servicios universitarios de su institución universitaria y el desarrollo de competencias profesionales, como el uso de software específico de su carrera.
أساليب الدعوة في حياة بعض الرسل و الأنبياء
Authors: حسن إبراهيم إبراهيم 
Published: February 2022

أساليب الدعوة في حياة بعض الرسل و الأنبياء
This research (The methods of “Dawa” in the life of some prophets and messengers) is composed of introduction, three themes and a number of inquiries.
The first theme illustrated the concept of methods (linguistically and terminologically) and also the most important methods of “Dawa” of those prophets.
The second theme is concerned with the task or function of prophets and messengers, with a full illustration to their struggling in order to execute this task.
In the last theme there wfre some samples of these methods through studying the life of some prophets and messengers.
شروط المفسر في مقدمة الكشاف للإمام الزمخشري
Authors: محمد سليمان حيدر 
Published: February 2022

شروط المفسر في مقدمة الكشاف للإمام الزمخشري
The most important conditions that occupied the talents of Qura’n Sciences of the commentators and the most important reason of putting these conditions is the great care of the savants of Islam about the Holy Qura’n which Alla, the Mighty, has promised to.
Many savants have written in this field and they have mentioned a number of conditions for competence to talk about Holy Qura’n and its interpretation.
One of those who were competent to this was the Imam Gar Alla Az zamakhshari who chose the most important tool of an interpreter is to be familiar with Arabic Language and to have the ability of eloquent extractions and literal constructions and there is no doubt he had been excellent in this field of eloquent interpretation where his interpetation “AlKashafT was considered as master in this respect
خضوع القرار الإداري لمبدأ المشروعية : دراسة قانونية فقهية مقارنة
Authors: عبد الإله عبد اللطيف محمد حامد 
Published: February 2022

خضوع القرار الإداري لمبدأ المشروعية : دراسة قانونية فقهية مقارنة
The research sheds light on the problem of the administrative conducts concerned with administrative decisions one issues and the extent of their conformity to the legislations organising the work and acquiring the common interest and to what extent they should be sticked to.
The research tackles the definition of administrative decision and the concept of the principle of the legislation and the effect of deviation of the administrative authority .
The study attained several principles aiming at linking the administrative decision with the legal responsibility