bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic inequality in barriers for accessing health care among married reproductive aged women in sub-Saharan African countries: a decomposition analysis
Authors: Alamneh Tesfa Sewunet , Teshale Achamyeleh Birhanu , Yeshaw Yigizie , Alem Adugnaw Zeleke , Ayalew Hiwotie Getaneh , Liyew Alemneh Mekuriaw , Tessema Zemenu Tadesse , Tesema Getayeneh Antehunegn , Worku Misganaw Gebrie 
Published: April 2022

Abstract
Background
Accessibility of health care is an essential for promoting healthy life, preventing diseases and deaths, and enhancing health equity for all. Barriers in accessing health care among reproductive-age women creates the first and the third delay for maternal mortality and leads to the occurrence of preventable complications related to pregnancy and childbirth. Studies revealed that barriers for accessing health care are concentrated among individuals with poor socioeconomic status which creates health inequality despite many international organizations top priority is enhancing universal health coverage. Therefore, this study aimed to assess the presence of socioeconomic inequality in barriers for accessing health care and its contributors in Sub-Saharan African countries.

Methods
The most recent DHS data of 33 sub-Saharan African countries from 2010 to 2020 were used. A total sample of 278,501 married reproductive aged were included in the study. Erreygers normalized concentration index (ECI) and its concentration curve were used while assessing the socioeconomic-related inequality in barriers for accessing health care. A decomposition analysis was performed to identify factors contributing for the socioeconomic-related inequality.

Results
The weighted Erreygers normalized Concentration Index (ECI) for barriers in accessing health care was − 0.289 with Standard error = 0.005 (P value < 0.0001); indicating that barriers in accessing health care was disproportionately concentrated among the poor. The decomposition analysis revealed that wealth index (42.58%), place of residency (36.42%), husband educational level (5.98%), women educational level (6.34%), and mass media exposure (3.07%) were the major contributors for the pro-poor socioeconomic inequalities in barriers for accessing health care.

Conclusion
In this study, there is a pro-poor inequality in barriers for accessing health care. There is a need to intensify programs that improve wealth status, education level of the population, and mass media coverage to tackle the barriers for accessing health care among the poor.
Predictors of patient safety competency among emergency nurses in Iran: a cross-sectional correlational study
Authors: Habibi Soola Aghil , Ajri-Khameslou Mehdi , Mirzaei Alireza , Bahari Zahra 
Published: April 2022

Abstract
Aims
This study aimed to assess predictors of patient safety competency among emergency nurses.

Background
The role of emergency nurses is to provide high-quality health care to patients and ensure their safety. The patient safety competency includes the absence of unnecessary or potential harm when providing health care to patients. In providing health care, effective teamwork can affect patient safety and outcomes. Psychological safety is essential to effective teamwork. Psychological safety allows health care workers to accept the interpersonal risks needed to perform effective teamwork and maintain patient safety.

Methods
This study was cross-sectional correlational research. Using convenience sampling methods, 254 emergency department nurses from five educational hospitals were enrolled in the study. Patient Safety in Nursing Education Questionnaire was used to measure the patient safety competency, the teamwork questionnaire to examine the teamwork, and Edmondson psychological safety questionnaire was used to measure psychological safety. Descriptive statistics, t-test, one-way analysis of variance (ANOVA), Pearson’s r correlation coefficient, and multivariate stepwise linear regression analysis were applied using SPSS 14.0.

Results
Participants’ mean patient safety competency score was 2.97 (1-4). Between 18 independent variables evaluated in the multiple regression analysis, seven had a significant effect on the patient safety competency of emergency nurses (R2: 0.39, p < .001).

Conclusions
The patient safety competency of emergency department nurses was primarily related to the structure and leadership of the team and secondary to psychological safety and experience in patient safety activity. The results demonstrated that policymakers and hospital managers should improve and enhance team structure and leadership via supervision and cooperation with the nursing staff. The development of training programs in patient safety activities, improvement, and increase of psychological safety at the levels of the nursing units is essential to increase patient safety competencies in the emergency nursing program.
A blockchain-based secure storage scheme for medical information
Authors: Sun Zhijie , Han Dezhi , Li Dun , Wang Xiangsheng , Chang Chin-Chen , Wu Zhongdai 
Published: April 2022

AbstractMedical data involves a large amount of personal information and is highly privacy sensitive. In the age of big data, the increasing informatization of healthcare makes it vital that medical information is stored securely and accurately. However, current medical information is subject to the risk of privacy leakage and difficult to share. To address these issues, this paper proposes a healthcare information security storage solution based on hyperledger fabric and the attribute-based access control framework. The scheme first utilizes attribute-based access control, which allows dynamic and fine-grained access to medical information, and then stores the medical information in the blockchain, which can be secured and tamper-proof by formulating corresponding smart contracts. In addition, this solution also incorporates IPFS technology to relieve the storage pressure of the blockchain. Experiments show that the proposed scheme combining access control of attributes and blockchain technology in this paper can not only ensure the secure storage and integrity of medical information but also has a high throughput when accessing medical information
Are cellulose ethers safe for the conservation of artwork? New insights in their VOC activity by means of Oddy testing
Authors: Steger Simon , Eggert Gerhard , Horn Wolfgang , Krekel Christoph 
Published: April 2022

Abstract
Cellulose ethers, like methyl cellulose (MC) or hydroxypropyl cellulose (HPC), are widely used in conservation. They also occur as additives and rheology modifiers in various products like dispersions or gels. Do such products release harmful volatile organic compounds (VOC) during their accelerated aging? A mass testing series utilizing the Oddy test of 60 commercial cellulose ethers ranks the products in safe for permanent use (P, no corrosion), only for temporary use (T, slight corrosion), and unsuitable at all (F, heavy corrosion). Results show that 55% of the products passed the test whereas 33% are for temporary use as slight corrosion occurred on at least one metal coupon and only 11% failed the Oddy test. Raman measurements of the corrosion products identified oxides like massicot, litharge, cuprite, and tenorite among carbonates (hydrocerussite, plumbonacrite), and acetates like basic lead acetate, lead acetate trihydrate as well as lead formate as main phases. For example, commercial, industrial Klucel® G (HPC) scored a T rating through slight corrosion on the lead coupon. Basic lead acetate among other phases indicates the presence of acetic acid. Additional measurements of the sample with thermal desorption GC–MS utilizing the BEMMA scheme confirm the high acetic acid outgassing and reveal the presence of a small amount of formaldehyde.
Comparative morpho-anatomical standardization and chemical profiling of root drugs for distinction of fourteen species of family Apocynaceae
Authors: Kumar Pankaj , Bhushan Anil , Gupta Prasoon , Gairola Sumeet 
Published: April 2022

Abstract
Background
The root drugs of the family Apocynaceae are medicinally important and used in Indian Systems of Medicine (ISM). There is often a problem of misidentification and adulteration of genuine samples with other samples in the market trade. Keeping in view the adulteration problem of raw drug material, comparative macroscopic and microscopic (qualitative and quantitative) characterisation and chemical analysis (TLC and LC–MS profiling) of a total of 14 economically important root drugs of family Apocynaceae were done for practical and rapid identification. A total of 33 qualitative botanical characteristics of root samples were subjected to Principal Component Analysis (PCA) and Cluster analysis to identify taxonomically significant characteristics in the distinction of root drug samples at the species level.

Results
Comparative qualitative and quantitative data on morphological, macroscopic, and microscopic characters were generated for the studied 14 species. Despite the similarity in some root characters, a combined study involving the surface, anatomical, and powder features helped distinguish root samples at the species level. The relative relationship between selected species was represented as clustering or grouping in the dendrogram. PCA analysis determined significant characters leading to species grouping and identification. Results showed that clustering of xylem vessels in cross-section, pore size, and distribution in the cut root, the shape of starch grains, the thickness of cork zone were among the most notable characters in species distinction. Chemical profiling revealed unique fingerprints and content of chemical compounds, which were significant in identification of root drug samples.

Conclusions
The comparative botanical standards and chemical profiles developed in the present study can be used as future reference standards for the quick, easy, and correct identification of root drug samples to be used in the herbal drug industry. Further, the identified significant microscopic characters have the potential for taxonomic studies in species delimitation.
Improve data classification performance in diagnosing diabetes using the Binary Exchange Market Algorithm
Authors: Rezaei Faranak , Abbasitabar Maryam , Mirzaei Shirin , Kamari Direh Zahra , Ahmadi Sahar , Azizi Zahra , Danialy Darya 
Published: April 2022

AbstractToday's lifestyle has led to a significant increase in referrals to medical centers to diagnose various diseases. To this end, over the past few years, researchers have turned to new diagnostic methods, including data mining and artificial intelligence, intending to facilitate the detection process and increase reliability. The high volume of data available in medical centers can be considered one of the main problems in using these methods. The optimal selection of essential and influential features reduces the maximum dimension for better diagnosis with more reliability of results. In this paper, a new approach uses a Binary Exchange Market Algorithm (BEMA) to identify essential and practical features in the diabetes dataset and determine the best algorithm binary function (type of sigmoid function) to improve the performance of the EMA algorithm is presented. For validation and efficiency of the proposed BEMA algorithm, several SVM, KNN, and NB classification models have been used to train and test the final model. The results obtained from the evaluations show that the proposed BEMA-SVM combined method has a better performance than the previous methods to improve accuracy and offer an effect equivalent to 98.502%. Also, to provide better results and more reliability than the proposed method, researchers can use a combination of several classes with the proposed method, which is outside the scope of this study.
Evaluation of an extracorporeal ozone-based bactericide system for the treatment of Escherichia coli sepsis
Authors: Skorup Paul , Fransson Anette , Gustavsson Jenny , Sjöholm Johan , Rundgren Henrik , Özenci Volkan , Wong Alicia Y. W. , Karlsson Tomas , Svensén Christer , Günther Mattias 
Published: April 2022

Abstract
Background
Sepsis is associated with substantial mortality rates. Antibiotic treatment is crucial, but global antibiotic resistance is now classified as one of the top ten global public health risks facing humanity. Ozone (O3) is an inorganic molecule with no evident function in the body. We investigated the bactericide properties of ozone, using a novel system of extracorporeal ozone blood treatment. We hypothesized that ozone would decrease the concentration of viable Escherichia coli (E. coli) in human whole blood and that the system would be technically feasible and physiologically tolerable in a clinically relevant model of E. coli sepsis in swine.

Methods
The E. coli strain B09-11822, a clinical isolate from a patient with septic shock was used. The in vitro study treated E. coli infected human whole blood (n = 6) with ozone. The in vivo 3.5-h sepsis model randomized swine to E. coli infusion and ozone treatment (n = 5) or E. coli infusion and no ozone treatment (n = 5). Live E. coli, 5 × 107 colony-forming units (CFU/mL) was infused in a peripheral vein. Ozone treatment was initiated with a duration of 30 min after 1.5 h.

Results
The single pass in vitro treatment decreased E. coli by 27%, mean 1941 to 1422 CFU/mL, mean of differences − 519.0 (95% CI − 955.0 to − 82.98, P = 0.0281). pO2 increased (95% CI 31.35 to 48.80, P = 0.0007), pCO2 decreased (95% CI − 3.203 to − 1.134, P = 0.0069), oxyhemoglobin increased (95% CI 1.010 to 3.669, P = 0.0113). Methemoglobin was not affected. In the sepsis model, 9/10 swine survived. One swine randomized to ozone treatment died from septic shock before initiation of the treatment. Circulatory, respiratory, and metabolic parameters were not affected by the ozone treatment. E. coli in arterial blood, in organs and in aerobic and anaerobic blood cultures did not differ. Hemoglobin, leucocytes, and methemoglobin were not affected by the treatment.

Conclusions
Ozone decreased the concentration of viable E. coli in human whole blood. The system was technically feasible and physiologically tolerable in porcine sepsis/septic shock and should be considered for further studies towards clinical applications.
Distinctive signatures of pathogenic and antibiotic resistant potentials in the hadal microbiome
Authors: He Liuqing , Huang Xinyu , Zhang Guoqing , Yuan Ling , Shen Enhui , Zhang Lu , Zhang Xiao-Hua , Zhang Tong , Tao Liang , Ju Feng 
Published: April 2022

AbstractBackgroundHadal zone of the deep-sea trenches accommodates microbial life under extreme energy limitations and environmental conditions, such as low temperature, high pressure, and low organic matter down to 11,000 m below sea level. However, microbial pathogenicity, resistance, and adaptation therein remain unknown. Here we used culture-independent metagenomic approaches to explore the virulence and antibiotic resistance in the hadal microbiota of the Mariana Trench.ResultsThe results indicate that the 10,898 m Challenger Deep bottom sediment harbored prosperous microbiota with contrasting signatures of virulence factors and antibiotic resistance, compared with the neighboring but shallower 6038 m steep wall site and the more nearshore 5856 m Pacific basin site. Virulence genes including several famous large translocating virulence genes (e.g., botulinum neurotoxins, tetanus neurotoxin, andClostridium difficiletoxins) were uniquely detected in the trench bottom. However, the shallower and more nearshore site sediment had a higher abundance and richer diversity of known antibiotic resistance genes (ARGs), especially for those clinically relevant ones (e.g.,fosX,sul1, and TEM-family extended-spectrum beta-lactamases), revealing resistance selection under anthropogenic stresses. Further analysis of mobilome (i.e., the collection of mobile genetic elements, MGEs) suggests horizontal gene transfer mediated by phage and integrase as the major mechanism for the evolution of Mariana Trench sediment bacteria. Notably, contig-level co-occurring and taxonomic analysis shows emerging evidence for substantial co-selection of virulence genes and ARGs in taxonomically diverse bacteria in the hadal sediment, especially for the Challenger Deep bottom where mobilized ARGs and virulence genes are favorably enriched in largely unexplored bacteria.ConclusionsThis study reports the landscape of virulence factors, antibiotic resistome, and mobilome in the sediment and seawater microbiota residing hadal environment of the deepest ocean bottom on earth. Our work unravels the contrasting and unique features of virulence genes, ARGs, and MGEs in the Mariana Trench bottom, providing new insights into the eco-environmental and biological processes underlying microbial pathogenicity, resistance, and adaptative evolution in the hadal environment.
Development of an educational package for the universal human papillomavirus (HPV) vaccination programme: a co-production study with young people and key informants
Authors: Fisher Harriet , Chantler Tracey , Finn Adam , Kesten Joanna , Hickman Matthew , Letley Louise , Mounier-Jack Sandra , Thomas Clare , Worthington Katie , Yates Julie , Audrey Suzanne 
Published: April 2022

Abstract
Background
The English schools-based human papillomavirus (HPV) vaccination programme is routinely offered to all young people aged 12–13 years, to prevent cancers affecting the cervix, vulva, vagina, penis, anus and mouth. Lower uptake among some population groups has been identified, in part, because of unmet information needs among young people. To address these unmet needs we report intervention planning and development processes to co-produce an educational package about the HPV vaccine.

Methods
We used co-production research methodologies and the ‘person-based approach’ involving the following iterative stages: (i) collating and analysing primary and secondary evidence, including HPV vaccine communication materials, interviews and workshops; (ii) developing guiding principles; (iii) undertaking a behavioural analysis informed by the Behaviour Change Wheel and the Behaviour Change Technique taxonomy; (iv) development of a preliminary logic model; (v) co-production of resources, and; (vi) refinement of resources informed by feedback from young people and key informants.

Results
We co-produced EDUCATE, a theory-based educational package, that is designed to be delivered to young people prior to being offered the HPV vaccine to support uptake. Young people and key informants identified the following key issues to include as content: (i) HPV-related information; (ii) how vaccines work; (iii) safety and side-effects of the HPV vaccine; (iii) eligibility for the HPV vaccination programme, and; (iv) preparation of young people to receive the HPV vaccine. A manual for professionals (e.g. immunisation nurses, school staff) delivering the intervention and a PowerPoint presentation, interspersed with five short films, were co-produced with young people and key informants. Following feedback, the content of the EDUCATE package was refined to increase acceptability, engagement, and persuasiveness to the target users.

Conclusion
Engagement with young people and key informants was integral to the development of our rigorously developed, theory-based intervention to address young people’s information needs about the HPV vaccination programme. The acceptability and persuasiveness of the package has been maximised by working closely with young people and key informants to develop the content. An implementation study to examine how the EDUCATE package is implemented in practice and the impact on uptake of the HPV vaccination programme is underway.
PTSD is associated with impaired event processing and memory for everyday events
Authors: Pitts Barbara L. , Eisenberg Michelle L. , Bailey Heather R. , Zacks Jeffrey M. 
Published: April 2022

AbstractCurrent theories of posttraumatic stress disorder (PTSD) propose that memory abnormalities are central to the development and persistence of symptoms. While the most notable memory disturbances in PTSD involve memory for the trauma itself, individuals often have trouble remembering aspects of everyday life. Further, people with PTSD may have difficulty segmenting ongoing activity into discrete units, which is important for our perception and later memory of the activity. The current study investigated whether PTSD diagnosis and symptom severity predicted event segmentation and memory for everyday activities. To do so, 63 people with PTSD and 64 controls with a trauma history watched, segmented, and recalled videos of everyday activities. Viewers with higher PTSD symptom severity showed lower agreement on locations of event boundaries and recalled fewer fine-grained actions than did those with lower symptom severity. These results suggest that PTSD symptoms alter event segmentation, which may contribute to subsequent memory disturbances.
Temperature change of the pulpal floor and restoration with preheated bis-GMA free and containing resin composite (a randomized clinical trial)
Authors: Nasser AlShimaa , Mahmoud Nermin A. , Riad Mona I. 
Published: April 2022

Abstract
Background
Preheating is one of several innovative approaches and improvements developed to increase the durability and clinical behavior of resin composites. Development of preheated composites is to reduce its viscosity in order to improve resin composite adaptation and placement ease. The purpose of this clinical trial was to study the effect of preheating Bis-GMA free and Bis-GMA-containing resin composites at different temperatures on the pulpal floor and restoration temperature. A total of twenty individuals (N = 40) have two carious posterior teeth that need to be restored were randomly assigned to one of two groups based on the type of restorative materials used: (group 1) Bis-GMA-containing resin composite VisCalor bulk (VCB), and (group 2) Bis-GMA-free resin composite Admira Fusion x-tra (AFX). Preheating temperatures of 50 °C and 70 °C were utilized to separate each group into two subgroups. Class I or II cavities were prepared. Thermometer device with two separate K-type temperature probes was used to measure the base line temperature values at the pulpal floor before beginning the restorative procedure (C0), pulpal floor during packing of preheated composite (C1), the top composite surface after packing and before curing (C2), pulpal floor after curing of the preheated composite (C3), and top composite surface after curing (C4). One-way ANOVA and the Kruskal–Wallis test were used to analyze the data.

Results
The measured temperature of pulpal floor for both preheated VCB or AFX at 50 °C or 70 °C revealed significant increasing from base line measured temperature to during packing as well as after curing with (P-value < 0.001). There was no significant difference for mean composite surface temperature for both preheated materials at 50 °C or 70 °C whether before or after curing.

Conclusions
Preheating of bulk fill Bis-GMA free and containing resin composite rises both the pulpal floor and the restoration temperature; meanwhile, the rise in temperature was limited. The application of the curing unit caused the greatest temperature rise.