bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aids, drogas e “ser mulher”
Authors: Franco Fabiana Gaspar , Figueiredo Marco Antonio Castro 
Published: February 2022

Tendo em vista o status subprivilegiado e a vulnerabilidade social da mulher, foram entrevistadas dez usuárias de drogas injetáveis, portadoras do HIV/Aids, atendidas na Unidade Especial de Tratamento de Doenças Infecciosas (U.E.T.D.I.), do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. As entrevistas, semi-estruturadas, enfocaram categorias temáticas a priori, complementadas por relatos sobre histórias de vida. Uma análise de conteúdos permitiu o levantamento de algumas representações sobre os temas enfocados: a) para ser mulher, foram identificados conteúdos relacionados à vulnerabilidade ao contágio por HIV, naturalização do papel feminino e resistência à subordinação; b) com respeito ao convívio com o HIV/Aids, conteúdos sobre banalização do contágio, estigma, perdas sociais/materiais, reconstruções e sentimentos adversos; c) relacionado a ser usuária de drogas injetáveis, representações sobre fuga à realidade, dependência e valorações negativas a respeito do desamparo. Tais resultados são discutidos com a perspectiva de subsidiar a orientação de futuros programas de orientação e suporte, considerando a vulnerabilidade feminina, principalmente quanto ao uso de drogas ilícitas e ao contágio por HIV/Aids.
Marx, Hegel e o valor dos ideais “burgueses”
Authors: Neuhouser Frederick , Taufer Felipe 
Published: February 2022

Tradução de Neuhouser, F. (2018). Marx and Hegel on the Value of ‘Bourgeois’ Ideals. In: Kandiyali, J. (Eds.) Reassessing Marx’s Social and Political Philosophy. New York: Routledge, pp. 149-162.
Traduzido por Felipe Taufer (Doutorando em Filosofia no Programa de Pós-Graduação da Universidade de Caxias do Sul)
Precedido por: Liberdade, crítica e patologias sociais: Frederick Neuhouser e os compromissos normativos do “jovem Marx”. Apresentação à tradução de “Marx, Hegel e o valor dos ideais ‘burgueses’”, de Frederick Neuhouser, por Felipe Taufer
Usabilidade de um sistema de monitoramento das internações em pronto-socorro
Authors: Rocha Hertaline Menezes do Nascimento , Nascimento Ester Batista do , Santos Laryssa Carvalho dos , Alves Guilherme Viturino , Farre Anny Giselly Milhome da Costa , Santana-Filho Valter Joviniano de 
Published: February 2022

OBJETIVO
Desenvolver e avaliar a usabilidade de um sistema de monitoramento das internações em pronto-socorro.

MÉTODOS
Trata-se de uma pesquisa aplicada, com desenvolvimento de um produto de software e avaliação de sua usabilidade por enfermeiros especialistas. O desenvolvimento seguiu quatro etapas: revisão sistemática, estruturação do arcabouço do sistema, construção dos formulários do sistema e avaliação das informações geradas. Na avaliação, os especialistas simularam a utilização do sistema com a inserção de dados de um prontuário fictício, e a usabilidade foi medida pelo System Usability Scale (SUS). A pontuação e os escores foram calculados de forma individual e global. O sistema foi avaliado nos padrões: pior imaginável, pobre, mediano, bom, excelente e melhor imaginável.

RESULTADOS
O Sistema de Informação e Monitoramento das Internações em Pronto-Socorro (SIMIPS) realiza o monitoramento do perfil epidemiológico das internações no pronto-socorro, gestão de tempo, deterioração clínica, incidência de eventos adversos e gestão de recursos humanos. A usabilidade do SIMIPS, avaliada por 17 especialistas, atingiu o Score SUS 86,5 (melhor imaginável), e algumas sugestões de modificações foram acatadas.

CONCLUSÕES
O SIMIPS foi avaliado como uma ferramenta de fácil utilização, com real importância na gestão das urgências frente aos problemas de superlotação e congestão, enfrentados no Brasil.
Frege’s View of the Context Principle After 1890
Authors: Bogucki Krystian 
Published: February 2022

Abstract
The aim of this article is to examine Frege’s view of the context principle in his mature philosophical doctrine. Here, the author argues that the context principle is embodied in the contextual explanation of value-ranges presented in Basic Laws of Arithmetic. The contextual explanation of value-ranges plays essentially the same role as the context principle in The Foundations of Arithmetic. It is supposed to show how a reference to natural numbers is possible. Moreover, the author argues against the view that the context principle should be separated from the recarving thesis. This aspect of Frege’s view leads the author to the rejection of the purely referential view of the context principle, which is fairly widely accepted in the current literature.
Infirm effect of phylogeny on morphometric features in a cryptic Gobio species complex
Authors: Takács Péter , Maasz Gabor , Zrínyi Zita , Boross Nóra , Vitál Zoltán , Sipos Dóra Ildikó Kánainé , Bánó Bálint , Staszny Ádám , Sály Péter , Kovács Balázs 
Published: February 2022

Abstract
Several recent notes prove that taxonomic relations of close relative animal groups (species complexes or cryptic species) can be revealed by the combined use of genetic and morphologic methodologies. At the same time scarce information can be found about how phylogeny, population origin, and sexual dimorphism affect the morphometric features of these species. In our present work, we performed simultaneous phylogenetic and morphological studies on the taxonomically still questionable Carpathian stream dwelling gudgeons (Cyprinidae, Gobio) by using two different methodologies (distance based and geometric morphometry). Our results were in correspondence with the previous findings, showing the presence of three phylogenetically more or less distinct groups in the area. The results of the whole-body geometric and the traditional, distance-based morphometry reflected the extent of phylogenetic differences. While the results of geometric scale morphometry did not correspond with the genetic subdivisions. Results of three way PERMANOVA analyses showed that the phylogenetic effects on morphometry is less considerable as the population origin or the sexual dimorphism at these cyprinid taxa. Our investigation contributed to the better understanding of the taxonomy of fish stocks in the Carpathian Basin, and to their conservation, but additional investigations will be needed to clarify the exact taxonomic position of the gudgeons (’Gobio sp1’) dominating the eastern part of the studied drainage.
Massive Transfusion Activations in Non-Trauma Patients
Authors: Dhillon Navpreet K. , Abumuhor Ihab , Hayes Chelsea , Nammalwar Shruthi , Ghoulian Joshua , Asadi Mona , Ley Eric J. 
Published: February 2022

Introduction Massive transfusion activations (MTAs) are commonly used in the care of the trauma patient. However, MTA for trauma patients constitutes only a small fraction of MTA at our institution. The aim of this study was to characterize MTA in non-trauma patients to better understand how this strategy is employed at a larger tertiary hospital. Methods All MTA involving non-trauma patients from January 2017 to April 2019 were reviewed. Patients with unclear indications for MTA were excluded. Data collected included patient demographics, reason for MTA, transfusion ratios, use of adjunctive antifibrinolytics, use of viscoelastic testing, and vasopressor administration at the time of MTA. Results There were 328 patients and 353 MTA identified over the study period. The mean age was 52.0 years and 40.9% were male. Patients were most commonly under the care of a medical service (55.2%), while 25.3% were obstetric patients and 19.5% were surgical patients. Compliance with 1:1:1 transfusion ratios was low. Concomitant vasopressor use was high (70.8%), while antifibrinolytic agents (13.0%) and viscoelastic testing (19.0%) were used less commonly. The overall mortality of the study population was 56.1%. Conclusions Massive transfusion activations are frequently used in non-trauma patients. There was a low rate of adherence to 1:1:1 transfusion ratios as well as utilization of adjuncts and tools that could allow for targeted resuscitation. Understanding practice patterns relating to MTA may allow for an opportunity for improvement.
Challenges in the management of advanced NSCLC among Italian oncologists: a 2019 national survey unfolds regional disparities
Authors: De Giglio Andrea , Orlando Valentina , Andrini Elisa , Ricciuti Biagio , Lamberti Giuseppe , Chiari Rita 
Published: February 2022

Background: Molecular testing is crucial for the implementation of personalized therapy in patients with lung cancer. Whether routine biomarker testing and access to personalized therapies are limited in some Italian regions is unclear. Patients and Methods: We conducted a national cross-sectional survey between April and June 2019 among Italian oncologists to determine differences in biomarker testing and access to personalized therapies for lung cancer. Results: Based on GIMBE report n. 3/2018, 32 respondents (37.6%) were defined as belonging to budget deficit regions (BDRs) while 53 (62.4%) were from balanced/positive budget regions (BPRs). Diagnostic assays for EGFR/ALK/ROS1 and PD-L1 were reported to be available in 47/53 (88.7%) and 22/32 (68.85%) centers from BPRs and BDRs, respectively (p=0.04). Liquid biopsy accessibility was wider in BPRs than in BDRs (75.5% (40/53) vs. 50% (16/32), respectively; p=0.03). 84/85 (98.8%) oncologists reported that ⩾75% of eligible patients received first-line targeted therapies. Reason for not administering first-line targeted therapies was defined as clinically-unrelated (molecular testing not available or incomplete, pharmacoeconomic issues) by 25/42 (59.5%) of respondents from BPRs and 21/26 (80.6%) from BDRs (p=0.12). Reason for not administering first-line pembrolizumab was defined as clinically-unrelated by 8/43 (18.6%) of respondents from BPRs and 10/22 (45.4%) from BDRs (p=0.039). Conclusion: Disparities in access to diagnostic assay and first line immunotherapy exist between BPRs and BDRs.
Proximal Fifth Metatarsal Fractures: A Retrospective Study of 834 Fractures With a Minimum Follow-up of 5 Years
Authors: Pettersen Petter Morten , Radojicic Nikola , Grün Wolfram , Andresen Tor Kristian Molstad , Molund Marius 
Published: February 2022

Background: Proximal fifth metatarsal fractures are common fractures. Treatment strategies have been debated. We wanted to investigate whether Lawrence and Botte’s classification has prognostic value because of time to fracture union, and evaluate if weightbearing as tolerated (WBAT) and nonweightbearing (NWB) treatment strategy had effect on time to fracture union in nonoperatively treated fractures. Methods: Computerized database search, patients diagnosed between January 1, 2003, and December 31, 2015. Results: We identified 834 fractures; 510 (61.2%) zone 1, 157 (18.8%) zone 2, and 167 (20.0%) zone 3. Most (94.4%) were treated nonoperatively; time to fracture union was 7.5 (SD 7.7), 7.7 (5.6), and 9.2 (8.1) weeks for zone 1, 2, and 3, respectively, which gave a significant longer time to union for zone 3 compared to zone 1 fractures ( P = .04). There was no difference in time to fracture union when comparing WBAT and NWB for all fracture zones. Failure to union, defined as crossover to surgery and/or delayed union, was found in 13 (2.7%) zone 1, 5 (3.2%) zone 2, and 6 (3.8%) zone 3 fractures. Refracture during follow-up was found in 3 (0.6%) zone 1 and 14 (8.9%) zone 3 fractures. Conclusion: Proximal fifth metatarsal fractures have high union rates with nonoperative treatment. No difference in time to union could be found between WBAT and NWB treatment strategies for all fracture zones. We observed a significantly longer time to fracture union for zone 3 fractures compared to zone 1 fractures. Refracture occurs in a nonnegligible share of nonoperatively treated zone 3 fractures.
Alcohol use among adolescents during the first pandemic lockdown in Denmark, May 2020
Authors: Hviid Signe Skovgaard , Pisinger Veronica , Hoffman Sofie Have , Rosing Johanne Aviaja , Tolstrup Janne Shurmann 
Published: February 2022

Objective: As alcohol is often consumed for social purposes, we aimed to explore how restrictions during the first Danish COVID-19 lockdown affected the alcohol use among adolescents aged 15–20. Method: In May 2020, 11,596 15- to 20-year-olds from two subpopulations answered a survey regarding their alcohol use and social life, as well as changes to these, during the Danish lockdown. Using survey data from all participants, we performed a multinomial logistic regression to assess the association between determinants of alcohol use and perceived change in alcohol use during the Danish lockdown. We used longitudinal data from one subpopulation ( n=1869) to perform negative binomial regressions exploring changes in frequency of alcohol use from 2019 to 2020. Results: Of all participants, 59% drank less, 75% had fewer in-person social interactions and 56% met more frequently online during lockdown. Girls were more likely than boys to have a perceived decrease in alcohol use during lockdown (odds ratio (OR)=1.41; 95% confidence interval (CI) 1.27–1.56). A perceived decrease in in-person social interaction during lockdown was associated with less drinking (OR=2.27; 95% CI 1.98–2.61), while a perceived increase in in-person social interaction during lockdown was associated with more drinking (OR=1.42; 95% CI 1.11–1.82) compared to unchanged drinking behaviour and social interaction. Conclusions: Adolescents in Denmark drank less during the Danish lockdown than before. Findings indicate that there is a close relationship between in-person social interactions and frequency of drinking. Drinking episodes when meeting online were rare and were not unambiguously associated with changes in drinking during lockdown.
Navigating Diabetes Online Communities in Clinical Practice
Authors: McLarney Meghan , Litchman Michelle L. , Greenwood Deborah , Drincic Andjela 
Published: February 2022

Objective: This purpose of this study was to conduct a rapid review and environmental scan of diabetes online communities (DOCs) to highlight the clinical impact of DOC engagement and provide guidance to health care providers for navigating and prescribing DOCs. Methods: This two-phase review included a rapid review of clinical outcomes and an assessment of DOC content. We conducted a literature search for studies evaluating DOC use and glucometric (glycated hemoglobin [A1C], time-in-range, hypoglycemia), behavioral, and psychosocial outcomes. The environmental scan of current DOC sites established key features, including available platforms, target population, content areas, and reach. Results: Twelve papers were included—eight reported DOC use within a context of do-it-yourself (DIY) noncommercial, opensource hybrid closed loop systems community and four were non-DYI related. In latter, all studies were cross-sectional, describing patient-reported outcomes. Two studies reported A1C lowering with DOC use, two DOC use was associated with high self-efficacy, one showed association with higher self-care levels, and one showed higher quality of life scores when compared with population norms. All DIY studies showed improvement in glucometrics after initiation of sensor augmented pump technology with DOC support. Of 54 DOC sites reviewed in the environmental scan, 29 were included. Diabetes online community sites were heterogenous in social media platform and type of diabetes targeted. Conclusion: Diabetes online communities have the potential to improve clinical, behavioral, and psychosocial outcomes. Randomized control trials and/or longitudinal prospective studies evaluating outcomes are needed to further examine the potential benefits of DOC use. Diabetes online communities are diverse and span a variety of social media platforms, providing clinicians opportunities to individualize recommendations for DOC use.
COVID-19: ASEAN Aviation Policy and the Significance of Intra-regional Connectivity
Authors: Law Colin C. H. , Katekaew Rungkaew 
Published: February 2022

Cross-border integration is a complex process, but it could bring benefits to the nations involved in motivating trade and tourism. Air transport has been playing an important role in accelerating the integration of the economies of countries in the Association of Southeast Asian Nations (ASEAN). The introduction of a visa-free exemption agreement in 2006 and the ratification of the semi-ASEAN open skies agreement in 2016 have stimulated intra-ASEAN travel and trade. However, since early 2020, the COVID-19 pandemic has demolished most of the efforts when tight border controls returned and flights were suspended. The ASEAN countries were criticised for a lack of coordination over the pandemic. This article examines the ASEAN air transport policies in response to the global pandemic. The data were collected from official government documents, international databases and local media reports to identify the pattern of the air transport policy implemented by each ASEAN member. This article provides insights into the impact of intra-regional travel on the recovery and resilience of the air transport industry in the ASEAN region. JEL Classification: L91, L93, L98
Therapeutic utility of percutaneous cecostomy in adults: an updated systematic review
Authors: Khayyat Yasir Mohammed 
Published: February 2022

Objective: Percutaneous cecostomy is a minimally invasive procedure that provides access to the colon for therapeutic interventions. This review aimed to update and summarize the existing information on the use and application of percutaneous endoscopic cecostomy in the field of therapeutic gastroenterology. Data Sources: A systematic review of the literature was performed without any restrictions on the year of publication from the date of inception in 1986 to January 2021. Methods: The review was performed using the medical subject heading keywords in the following search engines: MEDLINE, EMBASE, Cochrane, and Google Scholar. Results: A total of 29 articles were subjected to final data extraction. The review included a total of 174 patients who underwent percutaneous cecostomy. Most of the included studies were conducted in the United States ( n = 14). The most common comorbidity was cancer ( n = 10) and the major indication for performing percutaneous cecostomy was colonic pseudo-obstruction or Ogilvie’s syndrome ( n = 15). The main technique for performing percutaneous cecostomy was endoscopy (17 studies), followed by fluoroscopy- (five studies), computed-tomography- (three studies), laparoscopy- (two studies), and ultrasound- (one study) guided procedures. The procedure was technically successful in 153 (88%) cases. The total cumulative rates of major and minor complications were 47.5%. These complications included tube malfunction, local wound site infections, and bleeding and rare complications of peritonitis and death. Conclusion: Percutaneous cecostomy is a safe and effective option for managing acute colonic pseudo-obstruction. It leads to durable symptom relief with low to minimal risk.
When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
Authors: Masuelli Sofía , Real Sebastián , Campoy Emanuel , Branham María Teresita , Marzese Diego Matías , Salomon Matthew , De Blas Gerardo , Arias Rodolfo , Levin Michael , Roqué María 
Published: February 2022

AbstractBackgroundDuring embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast tumors exhibit consistently-biased incidence, gene expression, and DNA methylation. We postulate that a differential L/R tumor-microenvironment crosstalk generates different tumorigenesis mechanisms.MethodsWe performed in-silico analyses on breast tumors of public datasets, developed xenografted tumors, and conditioned MDA-MB-231 cells with L/R mammary extracts.ResultsWe found L/R differential DNA methylation involved in embryogenic and neuron-like functions. Focusing on ion-channels, we discovered significant L/R epigenetic and bioelectric differences. Specifically, L-sided cells presented increased methylation of hyperpolarizing ion channel genes and increased Ca2+concentration and depolarized membrane potential, compared to R-ones. Functional consequences were associated with increased proliferation in left tumors, assessed by KI67 expression and mitotic count.ConclusionsOur findings reveal considerable L/R asymmetry in cancer processes, and suggest specific L/R epigenetic and bioelectric differences as future targets for cancer therapeutic approaches in the breast and many other paired organs.
Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice
Authors: Huang Jiliang , Ru Gaizhen , Sun Jiajia , Sun Luying , Li Zhiling 
Published: February 2022

AbstractBackgroundMaternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly understood.MethodsWe established an obesity model in female mice by high-fat diet (HFD) feeding. The effects of the HFD on the developmental potential of oocytes and embryos, the metabolic phenotype, and epigenetic modifications were investigated. The efficacy of metformin administration was assessed. Finally, the regulatory pathway of epigenetic remodeling during zygotic genome activation (ZGA) was explored.ResultsMaternal HFD consumption significantly impaired glucose tolerance and increased the risk of metabolic disorders in F0 and F1 mice. Maternal HFD consumption also decreased embryonic developmental potential, increased reactive oxygen species (ROS) and γH2AX levels, and reduced the mitochondrial membrane potential (MMP) within oocytes, causing high levels of oxidative stress damage and DNA damage. Starting with this clue, we observed significantly increased RIF1 levels and shortened telomeres in obese mice. Moreover, significant abnormal DNA methylation and histone modification remodeling were observed during ZGA in obese mice, which may be coregulated by RIF1 and the ZGA marker gene MuERV-L. Metformin treatment reduced RIF1 levels, and partially improved ZGA activation status by rescuing epigenetic modification remodeling in oocytes and preimplantation embryos of obese mice. RIF1 knockdown experiments employing Trim-Away methods showed that RIF1 degradation altered the H3K4me3 and H3K9me3 enrichment and then triggered the MuERV-L transcriptional activation. Moreover, ChIP-seq data analysis of RIF1 knockouts also showed that RIF1 mediates the transcriptional regulation of MuERV-L by changing the enrichment of H3K4me3 and H3K9me3 rather than by altered DNA methylation.ConclusionElevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and increase metabolic risk in offspring by regulating histone modifications on MuERV-L, which can be partially rescued by metformin treatment.