bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity and safety of COVID-19 vaccine in lung cancer patients receiving anticancer treatment: A prospective multicenter cohort study
Authors: Nakashima Kei , Ishida Masayuki , Matsui Hiroyuki , Yoshida Chihiro , Nagai Tatsuya , Shiraga Minoru , Nakaoka Hiroshi , Otsuka Yoshihito , Nakagama Yu , Kaku Natsuko , Nitahara Yuko , Kido Yasutoshi , Hirota Yoshio 
Published: June 2022

AbstractIntroductionThis study assessed the immunogenicity and safety of BNT162b2 mRNA vaccine in lung cancer patients receiving anticancer treatment using two immunoassays. Methods: We enrolled lung cancer patients receiving anticancer treatment and non-cancer patients with chronic diseases; all participants were fully vaccinated with the BNT162b2 vaccine. Blood samples were collected before the first and second vaccinations and 4 ± 1 weeks after the second vaccination. Anti-acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein S1 subunit receptor-binding domain antibody titers were measured using the Architect SARS-CoV-2 IgG II Quant (Abbott Laboratory) and Elecsys Anti-SARS-CoV-2 S (Roche Diagnostics).ResultsFifty-five lung cancer patients and 38 non-cancer patients were included in the immunogenicity analysis. Lung cancer patients showed significant increase in the geometric mean antibody titer, which was significantly lower than that in the non-cancer patients after the first (30 vs. 121 AU/mL, p<0.001 on Architect; 4.0 vs 1.2 U/mL, p<0.001, on Elecsys) and second vaccinations (1632 vs. 3472 AU/mL, p=0.005, on Architect; 213 vs 573 A/mL, p=0.002, on Elecsys). The adjusted odds ratio (OR) for seroprotection was significantly lower in the lung cancer patients. Analysis of the anticancer treatment types showed that the adjusted OR for seroprotection was significantly lower in lung cancer patients receiving cytotoxic agents. Lung cancer patients showed no increase in the number of adverse reactions.ConclusionsBNT162b2 vaccination in lung cancer patients undergoing anticancer treatment significantly increased antibody titers and showed acceptable safety. However, the immunogenicity in these patients could be inadequate compared with that in non-cancer patients.
COVID-19 DISEASE IN PEDIATRIC EMERGENCY ROOM: THE DILEMMA OF CYCLE THRESHOLD VALUE
Authors: Timur Demet , Demirpek Uğur , Ceylan Demirbaş Başak , Türe Esra , Korkmaz Muhammed Furkan , Timur Ahmet 
Published: June 2022

ABSTRACTBACKGROUNDThe havoc of this SARS-CoV-2 pandemic was being distributed unequally. Children, of all ages, and in all countries, are being affected. Testing for infection with SARS-CoV-2, helps to determine what interventions may need to be put in place to control the spread of disease within a community. A PCR test for COVID-19 is a test used to diagnose children infected with SARS-CoV-2, the virus that causes COVID-19. Cycle threshold (Ct) is a semi-quantitative value that tells us approximately how much viral genetic material is in the sample following testing by RT-PCR. Our aim was to evaluate how RT-PCR Ct values among children with confirmed SARS-CoV-2 compared with clinical, laboratory and demographic data.MATERIALS AND METHODSIn the study, demographic, laboratory, radiological and clinical characteristics and the effect of Ct value of patients with positive Covid-19 PCR test who applied to the Emergency Pediatric Service with the suspicion of infectious disease between May 3,2020 and August 3, 2020 were retrospectively examined.RESULTSThere was no statistical significance between the patient’s hospitalization status, admission symptoms other than fever, and laboratory parameters and the mean Ct value. It was determined that the mean Ct value of the patients who had symptoms at the time of admission to the hospital was statistically significantly lower.CONCLUSIONIn this study, symptomatic patients had lower Ct than asymptomatic patients; this reflects the clinical impact of increased viral load. In our study, the low Ct values in symptomatic patients and higher values in asymptomatic patients; reflects the importance of the effect on the clinic with the increase of viral load. In evidence-based medicine practices, it will be useful to check the compatibility of complaints and findings with laboratory data while evaluating patients. In addition, if the patient is symptomatic and has a high ct value, co-infections should be considered.
Use of Chinese herbs to treat symptoms likely related to COVID-19: Survey analysis of licensed acupuncturists in the United States
Authors: Anderson Belinda J. , Zappa Melissa , Leininger Brent D. , Taylor-Swanson Lisa 
Published: June 2022

AbstractObjectiveThe objective of this study was to examine the prescribing of Chinese herbal medicine (CHM) by licensed acupuncturists in the United States during the COVID-19 pandemic.MethodsA 28-question survey with nine branching questions was disseminated through collegial networks, paid advertisements, and a study website in April-July 2021. Participants indicated they were licensed acupuncturists that treated more than five patients for symptoms likely related to COVID-19 to gain entry to the full survey. Surveys were undertaken electronically through the Research Electronic Data Capture (REDCap) system.ResultsThe survey was undertaken by 103 participants representing all US geographic regions, and had an average of 17 years in practice. Sixty-five percent received or intended to receive the COVID-19 vaccine. Phone and videoconference were the predominant methods of patient contact; granules and pill forms of CHM were the most commonly prescribed. A wide variety of information sources were used in devising patient treatments inclusive of anecdotal, observational, and scientific sources. Most patients were not receiving biomedical treatment. Ninety-seven percent of participants reported that they had no patients die of COVID-19, and the majority reported less than 25% of their patients developed long hauler syndrome (post-acute sequelae SARS-CoV-2 infection).ConclusionsThis study demonstrates that licensed acupuncturists were treating COVID-19 infected individuals in the US during the early stages of the pandemic, and for many such patients this was the only therapeutic intervention they had access to from a licensed healthcare provider. Information disseminated from China through collegial networks, along with published sources including scientific studies, informed the approach to treatment for the vast majority of the acupuncturists surveyed. This study provides insight into an unusual circumstance in which clinicians needed to establish evidence-based approaches to the treatment of a new disease in the midst of a public health emergency.Strengths and Limitations of the StudyDetailed survey that was widely disseminated through paid advertisements and a study web siteData was only collected from licensed clinicians who had treated more than five patients with symptoms likely related to COVID-19Survey was undertaken through the Research Electronic Data Capture (REDCap) systemStatistical analysis was undertaken to determine associations between question responsesThe survey was not psychometrically tested
Adrenal cortex size, homeostasis and tumorigenesis is regulated by gonadal hormones via androgen receptor/β-catenin signalling crosstalk
Authors: Lyraki Rodanthi , Grabek Anaëlle , Tison Amélie , Peitzsch Mirko , Bechman Nicole , Youssef Sameh A , de Bruin Alain , Bakker Elvira R.M. , Claessens Frank , Chaboissier Marie-Christine , Schedl Andreas 
Published: June 2022

AbstractFemale bias is highly prevalent among adrenal cortex hyperplasia and neoplasia, but the reasons behind this phenomenon are poorly understood. In this article, we show that overexpression of the secreted WNT agonist R-spondin-1 leads to ectopic activation of WNT/β-catenin signalling and causes sex-specific adrenocortical hyperplasia in mice. While female adrenals show ectopic proliferation, male adrenals display excessive immune system activation and cortical thinning. Using a combination of genetic manipulations and hormonal treatment, we show that gonadal androgens suppress ectopic proliferation in the adrenal cortex and determine the selective activation of WNT-related genes Axin2 and Wnt4. Notably, genetic removal of androgen receptor (AR) from adrenocortical cells restores the mitogenic effect of WNT/β-catenin signalling. This is the first demonstration that AR activity in the adrenal cortex determines susceptibility to canonical WNT signalling-induced hyperplasia.TeaserActivation of R-spondin signaling in the adrenal cortex leads to a sexually dimorphic phenotype causing tumors in females and immune cell recruitment in males
Effect of heterospecific and conspecific competition on individual differences in tadpole behaviour
Authors: Beyts Cammy , Cella Maddalena , Colegrave Nick , Downie Roger , Martin Julien G. A. , Walsh Patrick 
Published: June 2022

AbstractRepeated social interactions with conspecifics and/or heterospecifics during early development may drive the differentiation of behaviour among individuals. This behavioural differentiation may occur through individuals behaving more different from each other on average and/or individuals behaving more consistently. Competition is a major form of social interaction and its impacts can depend on whether interactions occur between conspecifics or heterospecifics and the directionality of a response could be specific to different behavioural traits. To test this, we reared tungara frog tadpoles (Engystomops pustulosus) either in isolation, with a conspecific tadpole or with an aggressive heterospecific tadpole, the whistling frog tadpole, Leptodactylus fuscus. In each treatment, we measured the body size, activity, exploration and risk taking in the presence of a predator in focal E. pustulosus tadpoles six times during development. We used univariate and multivariate hierarchical mixed effect models to investigate the effect of treatment on mean behaviour and on among individual variance between and within individuals across behavioural traits. There was a strong effect of competition on behaviour, with different population and individual level responses across social treatments. Within their home tank, individuals were more consistent in their movements under conspecific competition but heterospecific competition caused more variance in the average movement among individuals. Behavioural responses were also trait specific as conspecific competition caused greater variability in movements among individuals in a novel environment. The results highlight that the impact of competition on inter-individual differences in behaviour is dependent on competitor species identity and is trait specific.
The cynosure of CtBP: evolution of a bilaterian transcriptional corepressor
Authors: Raicu Ana-Maria , Kadiyala Dhruva , Niblock Madeline , Jain Aanchal , Yang Yahui , Bird Kalynn M. , Bertholf Kayla , Seenivasan Akshay , Arnosti David N. 
Published: June 2022

AbstractEvolution of sequence-specific transcription factors clearly drives lineage-specific innovations, but less is known about how changes in the central transcriptional machinery may contribute to evolutionary transformations. In particular, transcriptional regulators are rich in intrinsically disordered regions that appear to be magnets for evolutionary innovation. The C-terminal Binding Protein (CtBP) is a transcriptional corepressor derived from an ancestral lineage of alpha hydroxyacid dehydrogenases; it is found in mammals and invertebrates, and features a core NAD-binding domain as well as an unstructured C-terminus (CTD) of unknown function. CtBP can act on promoters and enhancers to repress transcription through chromatin-linked mechanisms. Our comparative phylogenetic study shows that CtBP is a bilaterian innovation whose CTD of about 100 residues is present in almost all orthologs. CtBP CTDs contain conserved blocks of residues and retain a predicted disordered property, despite having variations in the primary sequence. Interestingly, the structure of the C-terminus has undergone radical transformation independently in certain lineages including flatworms and nematodes. Also contributing to CTD diversity is the production of myriad alternative RNA splicing products, including the production of “short” tailless forms of CtBP in Drosophila. Additional diversity stems from multiple gene duplications in vertebrates, where up to five CtBP orthologs have been observed. Vertebrate lineages show fewer major modifications in the unstructured CTD, possibly because gene regulatory constraints of the vertebrate body plan place specific constraints on this domain. Our study highlights the rich regulatory potential of this previously unstudied domain of a central transcriptional regulator.
High accuracy indicators of androgen suppression therapy failure for prostate cancer – a modeling study
Authors: Meade William , Weber Allison , Phan Tin , Hampston Emily , Resa Laura Figueroa , Nagy John , Kuang Yang 
Published: June 2022

AbstractProstate Cancer is a serious public health concern in the United States. The primary obstacle to effective long-term management for prostate cancer patients is the eventual development of treatment resistance. Due to the uniquely chaotic nature of the neoplastic genome, it is difficult to determine the evolution of tumor composition over the course of treatment. Hence, a drug is often applied continuously past the point of effectiveness, thereby losing any potential treatment combination with that drug permanently to resistance. If a clinician is aware of the timing of resistance to a particular drug, then they may have a crucial opportunity to adjust the treatment to retain the drug usefulness in potential treatment combination or strategy. In this study, we investigate new methods of predicting treatment failure due to treatment resistance using a novel mechanistic model built on an evolutionary interpretation of Droop cell quota theory. We analyze our proposed methods using patient PSA and androgen data from a clinical trial of intermittent treatment with androgen deprivation therapy. Our results produce two indicators of treatment failure. The first indicator is calculated using our mathematical model with a predictive accuracy of 87.3% (sensitivity: 96.1%, specificity: 65%). The second indicator is calculated directly from serum androgen and PSA data with a predictive accuracy of 88.7% (sensitivity: 90.2%, specificity: 85%). The high sensitivity of the first indicator and the high specificity of the second indicator means they can complement one another in clinical settings. Our results demonstrate the potential and feasibility of using evolutionary tumor dynamics models in combination with the appropriate data to aid in the adaptive management of prostate cancer.
Chance-constrained programming with robustness for lot-sizing and scheduling problems under complex uncertainty
Authors: Hui Jizhuang , Wang Shuai , Bin Zhu , Xiong Guangwei , Lv Jingxiang 
Published: June 2022

Purpose
The purpose of this paper deals with a capacitated multi-item dynamic lot-sizing problem with the simultaneous sequence-dependent setup scheduling of the parallel resource under complex uncertainty.

Design/methodology/approach
An improved chance-constrained method is developed, in which confidence level of uncertain parameters is used to process uncertainty, and based on this, the reliability of the constraints is measured. Then, this study proposes a robust reconstruction method to transform the chance-constrained model into a deterministic model that is easy to solve, in which the robust transformation methods are used to deal with constraints with uncertainty on the right/left. Then, experimental studies using a real-world production data set provided by a gearbox synchronizer factory of an automobile supplier is carried out.

Findings
This study has demonstrated the merits of the proposed approach where the inventory of products tends to increase with the increase of confidence level. Due to a larger confidence level may result in a more strict constraint, which means that the decision-maker becomes more conservative, and thus tends to satisfy more external demands at the cost of an increase of production and stocks.

Research limitations/implications
Joint decisions of production lot-sizing and scheduling widely applied in industries can effectively avert the infeasibility of lot-size decisions, caused by capacity of lot-sing alone decision and complex uncertainty such as product demand and production cost. is also challenging.

Originality/value
This study provides more choices for the decision-makers and can also help production planners find bottleneck resources in the production system, thus developing a more feasible and reasonable production plan in a complex uncertain environment.
My dear handbags: materiality and networked constellations of consumption collections
Authors: Abarashi Jamal , Edirisingha Prabash Aminda 
Published: June 2022

Purpose
The purpose of this paper is to go beyond the market–consumer intersection and investigate consumer collecting as a network constellation, which includes a range of material and human actants.

Design/methodology/approach
This research adopts a qualitative research process that includes non-participatory netnography and semi-structured online interviews to collect both textual and visual data. Researchers drew from the field of visual anthropology to analyse the visual data. In addition, thematic analysis was used to identify, analyse and report the patterns within textual data.

Findings
Findings of this research reveals key agentic properties of collection constellations and explains how they contribute to the development of seriality and the experience of novelty by shaping curatorial practices within collection pursuits. From the time a collection has been assembled to its countless re-configurations, the network that is composed of a focal collector and a host of other actants interacting within a particular collecting ecology plays an essential role in challenging the agency of the market and the individual collectors.

Research limitations/implications
Although this research investigated consumer collecting from a network perspective, it did not explore changes within those constellations and how such changes implicate collecting behaviour. Therefore, future research may benefit from investigating network transformations on consumer collecting, particularly on curatorial practices and how they shape the trajectory of consumer collections.

Practical implications
Understanding collecting as a relational and iterative “network constellation” enables marketers to engage with their consumers in a more meaningful way. By actively seeking to use the network agentic properties, brands can aid avid handbag consumers and passionate collectors to keep their collections relevant and meaningful. It allows brands to play a role beyond the purchasing stage that characterises the market–consumer intersection and build comprehensive relationships with their consumers. Particularly, by adopting a networked approach, brands can provide collectors with privileged and scientific brand knowledge to help them caretake and experience their cherished possessions.

Originality/value
This study goes beyond the market–consumer intersection and atomistic explanations of collecting phenomena in its investigation and theorises collecting as a relational and iterative “network constellation”. It challenges the subject-oriented ontology of collections literature through explaining how such network interactions inspire collecting behaviours, help collectors maintain and celebrate their cherished collections and change the trajectory of collections pursuits.
Revisiting the financial market interdependence during COVID-19 times: a study of green bonds, cryptocurrency, commodities and other financial markets
Authors: Rao Amar , Gupta Mansi , Sharma Gagan Deep , Mahendru Mandeep , Agrawal Anirudh 
Published: June 2022

PurposeThe purpose of the present study is to contribute to the existing literature by examining the nexus and the connectedness between classes S&P Green Bond Index, S&P GSCI Crude Oil Index, S&P GSCI Gold, MSCI Emerging Markets Index, MSCI World Index and Bitcoin, during the pre-and post-Covid period beginning from August 2011 to July 2021 (10 years).Design/methodology/approachThe study employs time-varying parameter vector autoregression and Quantile regression methods to understand the impact of events on traditional and upcoming asset classes. To further understand the connectedness of assets under consideration, the study used Geo-Political Risk Index (GPR) and Global Economic Policy and Uncertainty index (GPEU).FindingsFindings show that these markets are strongly linked, which will only expand in the post-pandemic future. Before the pandemic, the MSCI World and Emerging Markets indices contributed the most shocks to the remaining market variables. Green bond index shows a greater correlation and shock transmission with gold. Bitcoin can no longer be used as a good hedging instrument, validating the fact that the 21st-century technology assets. The results further opine that under extreme economic consequences with high GPR and GPEU, even gold cannot be considered a safe investment asset.Originality/valueFinancial markets and the players who administer and communicate their investment logics are heavily reliant on conventional asset classes such as oil, gas, coal, nuclear and allied groupings, but these emerging asset classes are attempting to diversify.
Estimating a financial uncertainty index for Saudi Arabia
Authors: Ben Haddad Hedi , Altamimi Sohale , Mezghani Imed , Medhioub Imed 
Published: June 2022

PurposeThis study seeks to build a financial uncertainty index for Saudi Arabia. This index serves as a leading indicator of Saudi economic activity and helps to describe economic fluctuations and forecast economic trends.Design/methodology/approachThis study adopts an extension of the Jurado et al. (2015) procedure by combining financial uncertainty factors with their net spillover effects on GDP and inflation to construct an aggregate financial uncertainty index. The authors consider 13 monthly financial variables for Saudi Arabia from January 2010 to June 2021.FindingsThe empirical results show that the constructed financial uncertainty estimates are good leading indicators of economic activity. The robustness analysis suggests that the authors’ proposed financial uncertainty estimators outperform the alternative estimates used by other existing approaches to estimate the financial conditions index.Originality/valueTo the best of the authors’ knowledge, this is the first attempt at constructing a financial uncertainty index for Saudi Arabia. This study extends the empirical literature, from which the authors propose a novel conceptual framework for building a financial uncertainty index by combining the approach of Jurado et al. (2015) and the time-varying connectedness network approach proposed by Antonakakis et al. (2020)