bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dearth of the Author: Philip Massinger and the Beaumont and Fletcher Folio
Authors: Price Eoin 
Published: December 2022

Abstract
In 1647, Humphrey Moseley and Humphrey Robinson published a folio collection of unpublished works which they attributed to Francis Beaumont and John Fletcher, two writers famous for their collaborations from 1606 to 1613. But in affording Beaumont a place on the title page, the publishers misattributed the volume. Scholars now accept that Beaumont had very little direct input in the collection whereas Philip Massinger, who began collaborating with Fletcher soon after Beaumont’s retirement, had a very significant, unacknowledged role in the collected plays. This essay offers the first extended discussion of why it was that Massinger was written out of this canon-defining volume. I argue first that Massinger was by many accounts a popular and vendible dramatist, whose omission from the folio had little to do with him having a poor reputation. Instead, I suggest that the reputation of the names Beaumont and Fletcher, established in the preceding decades, proved irresistible to the publishers. Furthermore, I argue that Massinger’s reputation as a distinctive solo playwright also counted against him, making it harder to apprehend him as a prolific collaborator. Next, I demonstrate how the 1647 folio participated in a process of canonization which elided Massinger’s significant collaborative contribution and discuss the distorting effect this has had on our understanding of Beaumont, Fletcher, Massinger, and playwrighting practice more broadly. I end by pointing towards some ways of rectifying the historical elision of Massinger’s collaboration with Fletcher.
RADIOLOGICAL ASSESSMENT OF NATURAL RADIOACTIVITY IN A URANIUM DEPOSIT AREA: KÖPRÜBAŞI, TÜRKIYE
Authors: Bıyık Recep , Bingöldağ Nesli , Ataksor Berna , Duhan Fatma 
Published: December 2022

AbstractIn this study, the results of environmental radioactivity studies conducted in Köprübaşı, Manisa district, where Türkiye’s uranium mineral exploration and processing studies were carried out, are shared. Because this is a populated area, there is a need for radio ecological dosimetry assessment to investigate the possible risk to the population. The region where radiological monitoring is carried out is discussed in two parts as the areas where uranium mineral exploration is performed and the settlements close to these areas. It was observed that 714–4714 nGy/h values were obtained in the outdoor absorbed dose rate in air measurements taken in the areas where mineral exploration was performed and this value reached up to 22 857 nGy/h in open field mining areas. In the residential areas, it was recorded that the outdoor absorbed dose rate in air values ranged between 142 and 242 nGy/h and the indoor values ranged between 171 and 400 nGy/h. The world absorbed dose rate in air average values is 57 nGy/h (outdoor) and 75 nGy/h (indoor). The high 226Ra values in the radioactivity analyses of the soil samples draw attention. The mean values of the activity concentrations of the radionuclides 226Ra, 232Th and 40K in the soil samples are 3169, 55 and 802 Bq/kg and the world averages of these values are 35, 30 and 400 Bq/kg, respectively. It was determined that high 226Ra value in the soil in the areas close to the open field uranium mining area was passed on to the agricultural products. Radioactivity measurement results of drinking water samples did not exceed World Health Organization guidelines. According to the radon gas measurement results of 44 houses in Köprübaşı villages, the average radon concentrations in winter, spring, summer and autumn seasons were 72, 61, 50 and 55 Bq/m3, and the annual average value was 60 Bq/m3, respectively. Although these values are greater than the world average of 46 Bq/m3, they are below the recommended limit value (100 Bq/m3). By evaluating the data obtained, the total annual effective equivalent dose values (originating from outdoor–indoor absorbed dose in air, drinking water and indoor radon gas concentration) to which the people in the region are exposed were calculated as a 3.12 mSv.
When is caring sharing? Primary care provider interdependence and continuity of care
Authors: Everett Christine M. , Christy Jacob , Morgan Perri A. , Docherty Sharron L. , Smith Valerie A. , Anderson John B. , Viera Anthony , Jackson George L. 
Published: December 2022

Abstract
Efforts to improve access to high-quality, efficient primary care have highlighted the need for team-based care. Most primary care teams are designed to maintain continuity of care between patients and primary care providers (PCPs), because continuity of care can improve some patient outcomes. However, PCPs are interdependent because they care for, or share, patients. PCP interdependence, and its association with continuity of care, is not well described. This study describes a measure of PCP interdependence. We also evaluate the association between patient and panel characteristics, including PCP interdependence. Our results found that the extent of interdependence between PCPs in the same clinic varies widely. A range of patient and panel characteristics affect continuity of care, including patient complexity and PCP interdependence. These results suggest that continuity of care for complex patients is sensitive to panel characteristics, including PCP interdependence and panel size. This information can be used by primary care organizations for evidence-based team design.
Identifying Meaningful Patterns of Internal Medicine Clerkship Grading Distributions: Application of Data Science Techniques Across 135 U.S. Medical Schools
Authors: Burk-Rafel Jesse , Reinstein Ilan , Park Yoon Soo 
Published: December 2022

Problem
Residency program directors use clerkship grades for high-stakes selection decisions despite substantial variability in grading systems and distributions. The authors apply clustering techniques from data science to identify groups of schools for which grading distributions were statistically similar in the internal medicine clerkship.

Approach
Grading systems (e.g., honors/pass/fail) and distributions (i.e., percent of students in each grade tier) were tabulated for the internal medicine clerkship at U.S. MD-granting medical schools by manually reviewing Medical Student Performance Evaluations (MSPEs) in the 2019 and 2020 residency application cycles. Grading distributions were analyzed using k-means cluster analysis, with the optimal number of clusters selected using model fit indices.

Outcomes
Among the 145 medical schools with available MSPE data, 64 distinct grading systems were reported. Among the 135 schools reporting a grading distribution, the median percent of students receiving the highest and lowest tier grade was 32% (range: 2%–66%) and 2% (range: 0%–91%), respectively. Four clusters was the most optimal solution (η2 = 0.8): cluster 1 (45% [highest grade tier]–45% [middle tier]–10% [lowest tier], n = 64 [47%] schools), cluster 2 (25%–30%–45%, n = 40 [30%] schools), cluster 3 (20%–75%–5%, n = 25 [19%] schools), and cluster 4 (15%–25%–25%–25%–10%, n = 6 [4%] schools). The findings suggest internal medicine clerkship grading systems may be more comparable across institutions than previously thought.

Next Steps
The authors will prospectively review reported clerkship grading approaches across additional specialties and are conducting a mixed-methods analysis, incorporating a sequential explanatory model, to interview stakeholder groups on the use of the patterns identified.
Advances in antibody-drug conjugates for gynecologic malignancies
Authors: Tymon-Rosario Joan , Gorman Megan , Richardson Debra L. , Washington Christina , Santin Alessandro D. 
Published: December 2022

Purpose of review
Antibody-drug conjugates (ADCs) represent a new class of drugs that combine a surface receptor-targeting antibody linked to a cytotoxic molecule delivering the potent cytotoxic payload directly to tumor cells. This review summarizes the current literature demonstrating their use in the treatment of gynecologic malignancies.

Recent findings
Tisotumab vedotin is the first U.S. Food and Drug Administration (FDA) approved ADC for the treatment of gynecologic cancers. While in the phase 3 randomized controlled trial in platinum resistant ovarian cancer patients, FORWARD 1, mirvetuximab did not meet its primary endpoint of progression-free survival. But we await more recent data from the two ongoing phase 3 trials of mirvetuximab in recurrent ovarian cancer patients. HER2/neu, Napi2b, mesothelin, and human trophoblast cell-surface marker (Trop-2) overexpression have also been exploited as excellent targets by novel ADCs in multiple tumors including ovarian, endometrial, and cervical cancers.

Summary
Current evidence strongly supports the use of ADCs and ongoing clinical trials will provide further information into the potential of making these drugs part of current standard practice allowing patients to be treated with a higher level of personalized cancer care.
Cataract surgery and the risk of progression of macular degeneration
Authors: Bhandari Sanjeeb , Chew Emily Y. 
Published: December 2022

Purpose of review
Cataract surgery improves vision loss due to cataracts in eyes with co-existing age-related macular degeneration (AMD), but whether surgery itself pose an increased risk for the progression of AMD has been of concern to both physicians and their patients. This review describes evidence on cataract surgery and its impact on the progression of AMD.

Recent findings
Recent evidence suggests that cataract surgery does not increase the risk for progression of AMD.

Summary
Cataract surgery should be discussed in patients with both AMD and visually significant cataract. Patients should be reassured that the cataract surgery will not increase the risk of AMD progression. In patients with AMD, especially those with the more severe intermediate stage and those with advanced AMD in the fellow eye, the natural course of progression to late AMD is high. The importance of vigilant follow-up needs to be emphasized for the detection of natural progression of the disease and early initiation of treatment should signs of neovascularization develop.
Epicardial atherosclerosis and coronary tortuosity in patients with acetylcholine-induced coronary spasm
Authors: McChord Johanna , Gollwitzer Robert , Seitz Andreas , Sechtem Udo , Bekeredjian Raffi , Ong Peter 
Published: December 2022

Background
Angina pectoris in the absence of relevant epicardial stenoses is frequently caused by coronary spasm. This mechanism of angina is common yet underdiagnosed in daily clinical practice. The pathophysiology of coronary spasm is complex, multifactorial, and not completely understood. The purpose of this study was to analyze the relationship between macroscopic coronary morphologies and coronary spasm.

Methods
Epicardial atherosclerosis, coronary vessel tortuosity, coronary aneurysms, and myocardial bridges were analyzed angiographically in 610 patients and a potential association with the result of an intracoronary acetylcholine (ACh) provocation test was investigated.

Results
The comparison showed that angiographic morphologic variations in the coronary arteries are related to the occurrence of coronary spasm. We observed a strong association between the presence of epicardial atherosclerosis and epicardial spasm [87 patients of 179 with epicardial spasm had epicardial atherosclerosis (49%) vs. 45 patients of 172 with microvascular spasm (26%) vs. 89 patients of 259 with negative/inconclusive ACh test (36%); P < 0.005]. Moreover, we found a higher frequency of coronary tortuosity in patients with microvascular spasm [99 patients of 172 with microvascular spasm had at least moderate coronary tortuosity (58%) vs. 76 patients of 179 with epicardial spasm (43%) vs. 126 patients of 259 with negative/inconclusive ACh test (49%); P = 0.017]. Multivariable analysis revealed epicardial atherosclerosis (<50% stenosis) on coronary angiography as a predictor for epicardial spasm (OR, 2.096; 95% CI, 1.467–2.995; P < 0.0005). Female sex (OR, 5.469; 95% CI, 3.433–8.713; P < 0.0005), and exertional angina (OR, 2.411; 95% CI, 1.597–3.639; P < 0.0005) were predictors of microvascular spasm in multivariable analysis.

Conclusion
In angina patients with no obstructive coronary artery disease, epicardial atherosclerosis is associated with ACh-induced epicardial coronary spasm. Moreover, coronary microvascular spasm is more prevalent in female patients and those with exertional angina. Our results provide insights into the relationship between coronary morphology and coronary vasomotor function.
Everolimus-eluting bioresorbable scaffold versus everolimus-eluting metallic stent in primary percutaneous coronary intervention of ST-segment elevation myocardial infarction: a randomized controlled trial
Authors: Eriksen Erlend , Neghabat Omeed , Saeed Sahrai , Herstad Jon , Nordrehaug Jan Erik , Tuseth Vegard , Holm Niels Ramsing , Holck Emil Nielsen , Sejr-Hansen Martin , Maule Camilla Fox , Barkholt Trine Ørhøj , Andreasen Lene Nyhus , Christiansen Evald Høj , Bleie Øyvind 
Published: December 2022

Background
Primary percutaneous coronary intervention with implantation of a metallic drug-eluting stent (DES) is the standard treatment for patients presenting with ST-elevation myocardial infarction (STEMI). Implantation of a bioresorbable scaffold (BRS) during STEMI represents a novel strategy without intravascular metal.

Objective
The aim of the study was to investigate 12-month healing response in an STEMI population after implantation of either the Absorb BRS or Xience DES (Abbott Vascular, USA).

Methods
The present trial was a prospective, randomized, controlled, nonblinded, noninferiority study with planned inclusion of 120 patients with STEMI. Patients were randomly assigned 1:1 to treatment with Absorb BRS or Xience DES. Implantation result and healing response were evaluated by angiography and optical coherence tomography (OCT) at baseline and 12-month follow-up. The primary endpoint was minimum flow area (MFA) assessed at 12 months. Coronary stent healing index (CSHI) was calculated from OCT images.

Results
Out of 66 included patients, 58 had follow-up OCT after 12 months, and 49 entered matched analysis. One death occurred in each group; none were stent-related. MFA was 5.13 ± 1.70 mm2 (95% CI, 4.44–5.82) in the BRS group compared with 6.30 ± 2.49 mm2 (95% CI, 5.22–7.37) (P = 0.06) in the DES group. Noninferiority could not be evaluated. CSHI for both groups had a median score of 3.

Conclusion
The DES group performed numerically better in primary and secondary endpoints, but the CSHI showed good stent healing in both groups.
Validity and feasibility of the global leadership initiative on malnutrition diagnostic concept in older people: a literature review from August 2021 to August 2022
Authors: Cederholm Tommy , Barazzoni Rocco 
Published: December 2022

Purpose of review
Early 2019, the Global Leadership Initiative on Malnutrition (GLIM) concept offered a clinically applicable and objective procedure for diagnosing malnutrition. This review summarizes 40 publications from August 2021 to August 2022 that applied the GLIM criteria in older populations from various clinical settings for criterion and predictive validation.

Recent findings
Criterion validity studies, by comparing the GLIM construct with various semi-gold standards such as SGA, PG-SGA, MNA-FF/SF and ESPEN criteria, indicate by sensitivity, specificity and agreement that GLIM performs at least as well as the other tools to capture malnutrition. One meta-analysis of 20 studies with various comparators reports high accuracy for distinguishing malnutrition. GLIM-malnutrition prevalence figures vary with screening tool. Predictive validity of GLIM for mortality, and other outcomes, is good in all settings reported. Sarcopenia and GLIM show some expected overlapping.

Summary
In populations more than 60 years old, the GLIM construct appears to have well acceptable criterion validity as well as predictive validity. The continuous implementation of the GLIM concept is justified.
Scientific Advances and Technical Innovations in Musculoskeletal Radiology
Authors: Fritz Jan , Runge Val M. 
Published: December 2022

Abstract
Decades of technical innovations have propelled musculoskeletal radiology through an astonishing evolution. New artificial intelligence and deep learning methods capitalize on many past innovations in magnetic resonance imaging (MRI) to reach unprecedented speed, image quality, and new contrasts. Similarly exciting developments in computed tomography (CT) include clinically applicable molecular specificity and substantially improved spatial resolution of musculoskeletal structures and diseases. This special issue of Investigative Radiology comprises a collection of expert summaries and reviews on the most impactful innovations and cutting-edge topics in musculoskeletal radiology, including radiomics and deep learning methods for musculoskeletal disease detection, high-resolution MR neurography, deep learning–driven ultra-fast musculoskeletal MRI, MRI-based synthetic CT, quantitative MRI, modern low-field MRI, 7.0 T MRI, dual-energy CT, cone beam CT, kinematic CT, and synthetic contrast generation in musculoskeletal MRI.
Large-scale changes of molecular network states explain complex traits
Authors: Weith Matthias , Großbach Jan , Clement-Ziza Mathieu , Gillet Ludovic , Rodríguez-López María , Marguerat Samuel , Workman Christopher T. , Picotti Paola , Bähler Jürg , Aebersold Ruedi , Beyer Andreas 
Published: December 2022

AbstractThe complexity of many cellular and organismal traits results from poorly understood mechanisms integrating genetic and environmental factorsviamolecular networks. Here, we show when and how genetic perturbations lead to molecular changes that are confined to small parts of a networkversuswhen they lead to large-scale adaptations of global network states. Integrating multi-omics profiling of genetically heterogeneous budding and fission yeast strains with an array of cellular traits identified a central state transition of the yeast molecular network that is related to PKA and TOR (PT) signaling. Genetic variants affecting this PT state globally shifted the molecular network along a single-dimensional axis, thereby modulating processes including energy- and amino acid metabolism, transcription, translation, cell cycle control and cellular stress response. We propose that genetic effects can propagate through large parts of molecular networks because of the functional requirement to centrally coordinate the activity of fundamental cellular processes.Graphical abstractGraphical abstract:Genetic variants directly or indirectly affecting the activity of PKA and/or TOR signaling cause global changes of transcriptomic and proteomic network states by modulating the activity of diverse cellular functions and network modules. Using marker genes acting downstream of PKA and TOR signaling we are able to quantify the activity status of combined PKA and TOR signaling (‘PT Score’). This PT Score correlates with major transcriptomic and proteomic changes in response to genetic variability. Those large-scale molecular adaptations correlate with and explain phenotypic consequences for multiple cellular traits. Variants affecting the stoichiometry of proteins within a specific module have regional effects that remain confined to smaller parts of the molecular network. Variants affecting only one or very few proteins change molecular networks only locally. The global reorganization of network states caused by variants of the first type result in consequences for many cellular traits (i.e. pleiotropic effects), such as growth on different carbon sources, stress response, energy metabolism and replicative lifespan. (Created withBioRender.com)
BCLncRDB: A comprehensive database of LncRNAs associated with breast cancer
Authors: Kumar Swapnil , Agarwal Avantika , Vindal Vaibhav 
Published: December 2022

AbstractMotivationBreast cancer, the most common cancer in women, is characterized by high morbidity and mortality worldwide. Recent evidence has shown that long non-coding RNAs (lncRNAs) play a crucial role in the development and progression of breast cancer. Despite this, no database exists primarily for lncRNAs associated with only breast cancer.ResultsWe developed BCLncRDB, a manually curated, comprehensive database of lncRNAs associated with breast cancer. For this, we collected, processed, and analyzed data on breast cancer-associated lncRNAs from different sources, including published literature and TCGA. Currently, our database contains 5,279 unique breast cancer-lncRNA associations. It has the following features: (I) Differentially expressed and methylated lncRNAs, (II) Stage and subtype-specific lncRNAs, and (III) Drugs, Subcellular localization, Sequence, and Chromosome information. Thus, the BCLncRDB provides a dedicated platform for exploring breast cancer-related lncRNAs to advance and support the ongoing research on this disease.Availability and implementationThe database BCLncRDB is publicly available for use athttp://sls.uohyd.ac.in/new/bclncrdb.Contactvaibhav@uohyd.ac.in
Fungal traits help to understand the decomposition of simple and complex plant litter
Authors: Leifheit Eva F. , Camenzind Tessa , Lehmann Anika , Andrade-Linares Diana R. , Fussan Max , Westhusen Sophia , Wineberger Till M. , Rillig Matthias C. 
Published: December 2022

AbstractLitter decomposition is a key ecosystem process, responsible for the release and storage of nutrients and carbon. Soil fungi are one of the dominant drivers of organic matter decomposition, but fungal taxa differ substantially in their functional ability to decompose plant litter. We used a trait-based approach to better understand functional differences among saprotrophic soil fungi (originating from a natural grassland ecosystem) in decomposing leaf and wood litter. Decomposition strongly varied among phyla and isolates, with Ascomycota decomposing the most and Mucoromycota decomposing the least. In this study, the phylogeny of the fungi in our dataset, but also the ability of fungi to use more complex carbon were important predictors for decomposition. While some enzymes (e.g. laccase and cellulase) influenced decomposition, the majority of enzyme activities was not correlated with decomposition. Thus, we suggest using more directly assessed traits as predictors for decomposition, such as the ability to use carbon substrates, rather than a single enzyme activity, which could misrepresent the degradation potential of certain isolates. The findings of our study offer important new insights for the trait-based prediction of fungal litter decomposition in grassland soils.