bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a Novel Hepacivirus in White - tipped Shrew (Crocidura dracula) from Yunnan, China
Authors: Guo Ling , Li Bei , Dong Na , Zhu Yan , Li Fu-Li , Si Hao-Rui , Shi Zheng-Li , Yang Xing-Lou , Zhang Yunzhi 
Published: December 2022

Abstract
Hepacivirusgenus contains single-stranded positive-sense RNA viruses belonging to the family Flaviviridae, which contains 14 species. The 14 hepaciviruses were found in different mammals, such as primates, dogs, bats and rodents. To date, hepacivirus has not been reported in Crocidura animals. To study the prevalence and genetic evolution of hepacivirus in small mammals in Yunnan Province. Molecular detection of hepacivirus in small mammals from Yunnan Province during 2016- 2017 was performed by RT-PCR. Test results showed that the infection rate of hepacivirus in small mammals was 0.12% (2/1602), and the host animal was Crocidura dracula. Phylogenetic analysis and genetic analysis showed hepaciviruses obtained in this study don’t belong to any species of hepaciviruses, and form an independent clade. In general, a novel hepacivirus was identified for the first time in C. dracula specimens from Yunnan, China. And this study expanded the host range and viral diversity of hepaciviruses.
Status quo of advanced cancer patients participating in shared decision- making in China: A mixed study
Authors: Huang Shanshan , Wang Hongchao , Xu Xianghua , Bu Xiaofan , Xia Yimin , Liu Xiangyu 
Published: December 2022

Abstract
Purpose
Patients with advanced cancer are usually willing to participate in shared decision-making (SDM), but in clinical practice, the participation of patients is easily ignored due to many factors. This study aimed to analyze the current status of SDM among patients with advanced cancer in China and the related factors affecting patient participation.
Methods
A cross-sectional survey was conducted on 513 advanced cancer patients in 16 tertiary hospitals of China. The general situation questionnaire, the Control Preference Scale (CPS) and Perceived-involvement in Care Scale (PICS) were used to analyze the current status of SDM and influencing factors. Based on the Ottawa Decision Support Framework (ODSF), 17 advanced cancer patients were interviewed to explore the perceptions of advanced cancer patients on SDM.
Results
There is a difference between actual situation and expectation of patients' participation in decision-making tendency, and the statistically significant influencing factors were age, payment, and whether worried about the therapeutic effect. We also found the dynamic change of decision-making mode, the acquisition of disease information, the obstacles of decision-making participation and the role of family members would effect the type of patients' SDM.
Conclusion
The SDM status of advanced cancer patients in China is dominated by sharing, and in a continuous dynamic change. Influenced by Chinese traditional culture, family members play an important role in shared decision-making.
Influence of milling parameters on machining performances and surface quality of ZK61M magnesium alloy
Authors: Wang Chenguang , Chen Chang , Huang Zhiliang , Zhao Jun , Yang E 
Published: December 2022

Abstract
The milling parameters have an important influence on machining performance and surface quality of metal materials. In this paper, the differences in machining and corrosion resistance properties of ZK61M plates under different processing parameters were analyzed by side milling. The milling process was simulated to explore the change laws of milling temperature and milling force. The hardness of machined surface was observed by Vikers hardness tester. The surface quality and the corrosion performances under different spindle speeds were observed by 3D ultra-depth of field microscope. The results showed that the milling temperature was increased with the increase of spindle speed and feed speed. The influence of spindle speed and feed speed on milling force along the milling direction and the cutter direction was significant different. The milled surface had better quality when the spindle speed increased or the feed speed decreased. The hardness standard deviation of machined surface was decreased as the surface quality became better. Besides, it was summarized that how spindle speed played a role in corrosion resistance performance by affecting residual stress and metal oxides.
GIS-based calculation method of wave height generated by three-dimensional landslide
Authors: Yu Guo , Zhou Xiaowen , Bu Lei , Wang Chengfeng , Farooq Asim 
Published: December 2022

Abstract
Combined with the spatial data processing capability of geographic information systems (GIS), a three-dimensional (3D) landslide wave height calculation method is proposed based on grid column units. First, the data related to the landslide are rasterized to form grid columns, and a force analysis model of 3D landslides is established. Combining the vertical strip method with Newton's laws of motion, dynamic equilibrium equations are established to solve for the wave height. Moreover, a 3D landslide wave height calculation expansion module is developed in the GIS environment, and the results are compared with those of the two-dimensional Pan Jiazheng method. Comparisons show that the maximum wave height obtained by the proposed method is 24.6% larger than that based on the Pan Jiazheng method. Compared with the traditional two-dimensional method, the 3D method proposed in this paper better represents the actual spatial state of the landslide and is more suitable for risk assessment.
In Vitro propagation of Infectious Hypodermal Hematopoietic Necrosis Virus [IHHNV] / Penaeus stylirostris penstyldensovirus [PstDV1] in PmLyO-Sf9
Authors: Dominic Dominic Vithayathil Diya , Sajeevan Thavarool Puthiyedathu , Ameer Ahna , Muneer Abdulkhader , Eldho Linu , Anoop Bhaskaran Sathyabhama , Jayesh Puthumana , Joseph Valsamma , Philip Rosamma , Singh Isaac Sarojini Bright 
Published: December 2022

Abstract
Isolation and in vitro propagation of Infectious Hypodermal Hematopoietic Necrosis Virus (IHHNV/ PstDVI) in PmLyO-Sf9 could be successfully performed. After few hours of post inoculation with the virus, cytopathic changes such as (a) clustering (b) enlargement (c) syncytium formation (d) granulation (e) vacuole formation (f) tapering (g) irregular plasma membrane with extended tails (h) detachment (i) cell death and cellular debris formation were observed. Expression of viral genes, presence of virions and cytological changes demonstrated through TEM suggested replication of the virus in the shrimp - insect hybrid cell line. The virus could be purified by ultracentrifugation, negatively stained, and demonstrated under electron microscope. The same was found to be infective both in vitro and in vivo. This development opens avenues for the study of basic molecular mechanism of IHHNV infection, pathogenesis and replication kinetics much required for developing antiviral strategy in aquaculture.
Momentum Transfer from the DART Mission Kinetic Impact on Asteroid Dimorphos
Authors: Cheng Andrew , Agrusa Harrison , Barbee Brent , Meyer Alex , Farnham Tony , Raducan Sabina , Richardson Derek , Dotto Elisabetta , Zinzi Angelo , Corte Vincenzo Della , Statler Thomas , Chesley Steven , Naidu Shantanu , Hirabayashi Masatoshi , Li Jian-Yang , Eggl Siegfried , Barnouin Olivier , Chabot Nancy , Chocron Sidney , Collins Gareth , Daly Ronald , Davison Thomas , DeCoster Mallory , Ernst Carolyn , Ferrari Fabio , Graninger Dawn , Jacobson Seth , Jutzi Martin , Kumamoto Kathryn , Luther Robert , Lyzhoft Joshua , Michel Patrick , Murdoch Naomi , Nakano Ryota , Palmer Eric , Rivkin Andrew , Scheeres Daniel , Stickle Angela , Sunshine Jessica , Trigo-Rodriguez Josep , Vincent Jean-Baptiste , Walker James , Wünnemann Kai , Zhang Yun , Amoroso Marilena , Bertini Ivano , Brucato John , Capannolo Andrea , Cremonese Gabriele , Dallora Massimo , Deshapriya Prasanna , Gai Igor , Hasselmann Pedro , Ieva Simone , Impresario Gabriele , Ivanovski Stavro , Lavagna Michelle , Lucchetti Alice , Epifani Elena Mazzotta , Modenini Dario , Pajola Maurizio , Palumbo Pasquale , Perna Davide , Pirotta Simone , Poggiali Giovanni , Rossi Alessandro , Tortora Paolo , Zannoni Marco , Zanotti Giovanni 
Published: December 2022

Abstract
The NASA Double Asteroid Redirection Test (DART) mission performed a kinetic impact on asteroid Dimorphos, the satellite of the binary asteroid (65803) Didymos, at 23:14 UTC on September 26, 2022 as a planetary defense test1. DART was the first hypervelocity impact experiment on an asteroid at size and velocity scales relevant to planetary defense, intended to validate kinetic impact as a means of asteroid deflection. Here we report the first determination of the momentum transferred to an asteroid by kinetic impact. Based on the change in the binary orbit period2, we find an instantaneous reduction in Dimorphos’s along-track orbital velocity component of 2.70 ± 0.10 mm s–1, indicating enhanced momentum transfer due to recoil from ejecta streams produced by the impact3,4. For a Dimorphos bulk density range of 1,500 to 3,300 kg m–3, we find that the expected value of the momentum enhancement factor, β, ranges between 2.2 and 4.9, depending on the mass of Dimorphos. If Dimorphos and Didymos are assumed to have equal densities of 2,400 kg m–3, 〖β=3.61〗_(-0.25)^(+0.19) (1σ). These β values indicate that significantly more momentum was transferred to Dimorphos from the escaping impact ejecta than was incident with DART. Therefore, the DART kinetic impact was highly effective in deflecting the asteroid Dimorphos.
The emerging role of lysine succinylation in ovarian aging
Authors: le meiling , Li Jia , Zhang Dalei , Yuan Yuan , Zhou Chong , He Jinxia , Huang Jian , Hu Liaoliao , Luo Tao , Zheng Liping 
Published: December 2022

Abstract
Background
Ovarian aging is a process of decline in its reserve leading to ovary dysfunction and even reduced health quality in offspring. However, aging-related molecular pathways in the ovary remain obscure. Lysine succinylation (Ksuc), a newly post-translational modification (PTM), has been found to be broadly conserved in both eukaryotic and prokaryotic cells, and associated with multiple pathophysiological processes. There are no relevant reports revealing a link between the molecular mechanisms of ovarian aging and Ksuc.
Methods
The level of Ksuc in ovaries of aged and premature ovarian insufficiency (POI) mice and granulosa cells (GCs) derived from follicular fluid of women with POI were detected by immunoblotting and immunohistochemical. To further explore the role of Ksuc in ovarian aging, using in vitro mouse ovary tissue culture and an in vivo mouse model with changed Ksuc level.
Results
Increased Ksuc in ovaries of aged and POI mice and GCs derived from follicular fluid of women with POI, and distribution of Ksuc in various types of mice ovarian cells and the high level of Ksuc in GCs were revealed. Histological assessments and hormone levels analyses showed that the high Ksuc level down-regulated the ovarian index and the anti-Müllerian hormone (AMH) and estrogen levels, and increased follicular atresia. Moreover, in the high Ksuc groups, the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) intensities and the expression of Cleaved-caspase-3 increased and the expression of B-cell lymphoma-2 (Bcl-2) decreased together with positively-expressed P21, an aging-related marker. These results suggest that ovarian aging is likely associated with alteration in Ksuc.
Conclusion
The present study has identified Ksuc in mouse ovary and human GCs and found that high Ksuc level most likely contributes to ovarian aging which is expected further investigation to provide new information for delaying physiological ovarian aging and treating pathological ovarian aging.
An investigation of the potential effects of amitriptyline on polycystic ovary syndrome induced by estradiol valerate
Authors: Alkan Işınsu , Kaplan Süleyman 
Published: December 2022

Abstract
Polycystic ovarian syndrome (PCOS) is frequently observed in adolescent women and usually progresses with depression. The aim of this study was to examine the effects of amitriptyline (AMI), a drug used in the treatment of depression, in individuals with PCOS. Forty 12-week-old female Wistar albino rats were randomly divided into five groups; control, sham, PCOS, AMI, PCOS+AMI. In order to induce the syndrome in the PCOS groups, a single dose of 4mg/kg estradiol valerate was administered by intraperitoneal injection, 10mg/kg AMI was administered by intraperitoneal injection for 30days in the AMI groups. After 30days, all the animals were sacrificed and blood, ovary, brain tissues were collected, subjected to routine tissue processing. Stereological, histopathological analyses were performed on the ovarian sections, while LH, FSH, CAT, and SOD levels were investigated in blood samples. The volume of the corpus luteum and preantral follicles increased in the PCOS group, while a decrease was determined in the number of antral follicles using stereological methods. Biochemical analysis revealed that FSH levels increased and CAT enzyme levels decreased in the PCOS group. Significant morphological changes were observed in ovaries from the PCOS group. The volume of the corpus luteum in the PCOS+AMI group decreased compared to the PCOS group. Serum FSH levels decreased in the PCOS+AMI group, while CAT enzyme levels increased compared to the PCOS group. Degenerative areas were also seen in the PCOS+AMI group ovaries. AMI administration was unable to sufficiently ameliorate the morphological and biochemical changes caused in the ovarian tissues by PCOS.
Blockchain as a service environment: a dependability evaluation
Authors: Correia Leonel , Ramalho Jamilson , Silva Francisco Airton 
Published: December 2022

Abstract
Blockchain has become an important processing paradigm in recent years. The blockchain supports financial transactions and validates contracts, documents and data. However, the evolution of blockchain has become viable for many applications. The servers' availability and reliability (dependence) are required in the data processing. The contract will only be signed if there are enough components to form the blockchain blocks. This paper analyses the dependency between project components that use blockchain. We present a model based on stochastic Petri net (SPN) for evaluating the dependency of the blockchain architecture. The Design of Experiments (DoE) method was used to analyze this model's factors, seeking to know which ones had the higher impact on the system. The sensitivity analysis showed that the MongoDB component has a greater impact on the system dependency and the need to upgrade such a component. Also, for reliability, making component improvements is unnecessary if the system has fewer than 36,000 hours of runtime.
Freight Train Speed Active Disturbance Rejection Tracking and Wheel Anti-slip Based on T-S Fuzzy Neural Network
Authors: Lingzhi YI , yu YI , Chen LI , Chen Xie , dake Zhang , wenbo Jiang 
Published: December 2022

Abstract
A speed tracking control scheme is proposed for freight trains in this paper. This speed tracking scheme approach can prevent the wheel from slipping while controlling the traction motor to drive freight trains at an appropriate speed. Direct Torque Control (DTC) used by the HXD1 electric traction locomotive is applied in this strategy to control the asynchronous motor. Velocity tracking control is implemented by a Predictive Auto Disturbance Rejection Control (PADRC). Through an modified Smith estimator, this PADRC can predict the response of time-delay systems. In addition, an Unscented Kalman Filter (UKF) observer is designed. An adaptive parameter adjustment mechanism implemented by Affinity Propagation-Fuzzy Neural Network (AP-FNN) is also integrated into this observer. It is used to solve the problem that is difficult to measure the radial velocity and creep rate accurately. Using the anti-slip parameters obtained by this observer, the control scheme of anti-skid control is determined. Under wet and dry pavement conditions, an actual speed curve of a freight train is used to simulate and verify the effectiveness of this scheme.
Investigation on contact pressure of back-up roll with Parabolic chamfer curve and Intelligent Modeling of plate crown in plate rolling process
Authors: Ding Jingguo , Jin Li , Zhang Kai , Sun Jie 
Published: December 2022

Abstract
The work rolls of CVC rolling mills in plate rolling process adopt S-shaped roll profile curve, which change the contact situation between the rolls and make the contact pressure distribution between the rolls uneven. The peak of the contact pressure between the rolls appears at the end of the roll, which leads to peeling or “meat loss” at the end of the roll and poor plate crown control effect. To solve those problems, a CVC rolling mill back-up roll profile curve with parabolic chamfer was proposed, and Fusion model of plate crown based on mechanism and data-driven models was developed. Combining the parameters of the CVC roll profile curve, the theoretical calculation formula of the back-up roll chamfering was deduced. According to the actual data of the plate rolling mill, the parameters of different types of back-up roll chamfering were determined, and the distribution of contact pressure between the rolls under different back-up roll chamfering was calculated and analyzed by finite element model. Based on the new parabolic chamfer curve of back-up roll, the rolling force setting model based on ELM and the roll wear model based on GA-ANN were constructed by using the nonlinear fitting ability of machine learning algorithm, Then, the predicted results of rolling force and roll wear are taken as the input variables of plate crown prediction. At the same time, the roll system deformation model and roll bending force model based on mechanism model were introduced as inputs to construct the plate crown CNN model based on mechanism and data-driven fusion. The simulation results show that the parabolic chamfer can significantly reduce the pressure between the backup rolls. When the rolled strip width is 2000mm, 2400mm, and 2800mm, the parabolic chamfer can reduce the peak contact stress between the rolls by approximately 8.6% and 10.8%. When the rolling bending force is 1600kN, 2100kN, and 2600kN, the parabolic chamfer can reduce the peak contact stress between the rolls by approximately 8.6%, 8.9% and 9.1%. The hit ratio of plate crown increased from 90.4–96.5%, and the product degradation rate caused by the shape problem decreased by 35.5%.
Effect of Overground Gait Training with ‘Mobility Assisted Robotic System-MARS’ on Gait Parameters in Patients with Stroke: A Pre-post Study
Authors: Gupta Anupam , Prakash Navin , Sannyasi Gourav , Mohamad Faiz , Honavar Preethi , S Jotheeswaran , Khanna Meeka , Ramakrishnan Subasree 
Published: December 2022

Abstract
Objective
To observe the effect of overground gait training with ‘Mobility Assisted Robotic System-MARS’ on gait parameters in patients with stroke
Patients & Methods:
This prospective pre-post study was conducted in a tertiary teaching research hospital with 25 stroke patients with age ranging between 18–65 years. Patients fulfilling the inclusion criteria were divided in 2 groups based on the duration of stroke (≤ 6 months-sub-acute stroke & > 6 months-chronic stroke) and provided overground gait training with MARS robot for 12 sessions over a period of 2–3 weeks. Primary outcome measures were; 10-Meter walk test, 6-minutes’ walk test-6MWT and Timed up & Go-TUG tests. Secondary outcome measures were Functional Ambulation Category-FAC, Modified Rankin Scale-MRS and Scandinavian Stroke Scale-SSS.
Results
No adverse events were reported. Twelve patients in sub-acute stroke group and 13 patients in chronic stroke group were provided gait training for a period of maximum 1 hour per session. All primary and secondary outcome measures showed significant improvement in gait parameters at the end of the training (p < 0.05) barring 10-Meter walk test in sub-acute stroke group (p = 0.255). Chronic stroke group showed significant minimum clinically important difference-MCID difference in endurance (6MWT) at the end of the training and both groups showed better ‘minimal detectable change-MDC’ in balance (TUG) at the end of the training.
Conclusions
Overground gait training with MARS Robot is safe and efficacious. Patients showed significant improvement in walking speed, endurance, balance and independence at the end of the training.
Clinical Trial Registry
: National Clinical Trial Registry of India (CTRI/2021/08/035695)
Active Intrusion Detection &amp; Prediction based on Temporal Big Data Analytics
Authors: Jemili Farah 
Published: December 2022

Abstract

Computer security consists in protecting access and manipulating system data by several mechanisms. However, conventional protection technologies are ineffective against current attacks. Thus, new tools have appeared, such as the intrusion detection and prediction systems which are important defense elements for network security since they detect the ongoing intrusions and predict the upcoming attacks. Besides, most of conventional protection technologies remain insufficient in terms of actions since they are all passive systems, unable to provide recommendations in order to block or stop the attacks. In this paper, a distributed detection and prediction system, composed of three major parts, is proposed. The first part deals with the detection of intrusions based on the decision tree learning algorithm. The second part deals with intrusions prediction using the chronicle algorithm. The third part proposes an expert system for security recommendations in response to detected intrusions, able to provide appropriate recommendations to stop the attacks. The proposed system gives good results in terms of accuracy and precision in detecting and predicting attacks, and efficiency in proposing the right recommendations to stop the attacks.
Influence of Structural, Social and Hygienic Atmospheres to accessing Public Toilets in Dhaka, Bangladesh: A Qualitative Exploration
Authors: Hossain Syed Billal , Chowdhury ABM Alauddin , Mubarak Mahfuza , Humayra Ipsita , Shahjahan Md. 
Published: December 2022

Abstract

In the capital city of Dhaka, males are being prompted to urinate or defecate in public areas due to a lack of access to public toilets. Therefore, the goal of the study was to determine how the structural, social, and hygienic environments affected people's ability to utilize public toilets in Dhaka. This cross-sectional qualitative study was done in Dhaka between November 2016 and January 2017, with data collected from 29 public toilets located around the city's north and south parts. In order to collect data, semi-structured checklists for observing the current structural, social and Hygiene state of public toilets were utilized. There are 237 public toilets in the city that are operational, including Dhaka City Corporation -authorized and non-governmental public toilets. Due to the lack or inaccessibility of the nearest public toilet, residents in the city are accustomed to accessing the nearest restricted bathrooms such as Mosques, Filling stations, hospitals, and so on. Furthermore, the floor materials in all of the toilets were found to be slippery, and degradation of the roof, doors, windows, and interior walls of public toilets was a typical occurrence. In the public toilets we observed, poor supervision was also common. Most of the restrooms analyzed do not have a "Women Section," and several restrooms are famous for the crowding of onlookers, especially near the women's block. Although there are uncomfortable structural, sociological, and hygiene issues as well as unhygienic conditions in public toilets of Dhaka city, the authorities take the situation lightly.