bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of cardiomyopathies and incident heart failure in a population-based cohort study
Authors: Brownrigg Jack RW , Leo Vincenzo , Rose Joel , Low Eric , Richards Sarah , Carr-White Gerry , Elliott Perry M 
Published: December 2021

AimsThe population prevalence of cardiomyopathies and the natural history of symptomatic heart failure (HF) and arrhythmia across cardiomyopathy phenotypes is poorly understood. Study aims were to estimate the population-diagnosed prevalence of cardiomyopathies and describe the temporal relationship between a diagnosis of cardiomyopathy with HF and arrhythmia.MethodsPeople with cardiomyopathy (n=4116) were identified from linked electronic health records (~9 million individuals; 2000–2018) and categorised into hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), restrictive cardiomyopathy (RCM) and cardiac amyloidosis (CA). Cardiomyopathy point prevalence, rates of symptomatic HF and arrhythmia and timing relative to a diagnosis of cardiomyopathy were determined.ResultsIn 2018, DCM was the most common cardiomyopathy. DCM and HCM were twice as common among men, with the reverse trend for ARVC. Between 2010 and 2018, prevalence increased for ARVC by 180% and HCM by 9%. At diagnosis, more patients with CA (66%), DCM (56%) and RCM (62%) had pre-existing HF compared with ARVC (29%) and HCM (27%). Among those free of HF at diagnosis of cardiomyopathy, annualised HF incidence was greatest in CA and DCM. Diagnoses of all cardiomyopathies clustered around the time of HF onset.ConclusionsThe recorded prevalence of all cardiomyopathies increased over the past decade. Recognition of CA is generally preceded by HF, whereas individuals with ARVC or HCM more often developed HF after their cardiomyopathy diagnosis suggesting a more indolent course or better asymptomatic recognition. The clustering of HF and cardiomyopathy diagnoses suggests opportunities for presymptomatic or earlier diagnosis.
Trajectories of alcohol consumption up to 30 years before and after the diagnosis of cardiovascular diseases: a longitudinal case–control study of 12 502 participants
Authors: Ding Chengyi , O'Neill Dara , Britton Annie 
Published: December 2021

BackgroundTo examine the longitudinal trajectories of alcohol consumption prior to and following the diagnosis of cardiovascular diseases (CVD).MethodsWe conducted a case–control study of 2501 incident cases of angina, myocardial infarction or stroke and 10 001 matched controls without the condition. Repeated measures of alcohol were centred on the date of diagnosis, spanning up to 30 years before and after CVD onset. Mean trajectories of weekly consumption were estimated using growth curve models.ResultsFor trajectories prior to diagnosis, mean volume of alcohol consumed among male cases increased over time, peaking at around 8 years before diagnosis at 95 (95% CI 60 to 130) g/week and declining afterwards. Trajectories following diagnosis showed mean consumption in male cases dropped from 87 (95% CI 54 to 120) g/week to 74 (95% CI 45 to 102) g/week after the date of diagnosis and then slightly rose to 78 (95% CI 40 to 116) g/week at the subsequent 3.5 years, before gradually declining to 31 (95% CI 2 to 61) g/week at 30 years after diagnosis. Mean consumption among female cases remained stable prior to diagnosis (at about 30 g/week), fell marginally to 25 (95% CI 20 to 30) g/week after the date of diagnosis and kept decreasing afterwards. Similar trajectories were obtained in cases and controls.ConclusionsThis is the first attempt to show how patients with CVD change their drinking volume over such a wide time span. Future research needs to establish insight into drinking behaviour in other ways (such as frequency and context) and address the impact of changes in drinking on patients with CVD.
Atrial fibrillation detected at screening is not a benign condition: outcomes in screen-detected versus clinically detected atrial fibrillation. Results from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study
Authors: Zwartkruis Victor W , Geelhoed Bastiaan , Suthahar Navin , Bakker Stephan J L , Gansevoort Ron T , van Gelder Isabelle C , de Boer Rudolf A , Rienstra Michiel 
Published: December 2021

AimsIt is unknown whether screen-detected atrial fibrillation (AF) carries cardiovascular risks similar to clinically detected AF. We aimed to compare clinical outcomes between individuals with screen-detected and clinically detected incident AF.MethodsWe studied 8265 participants (age 49 ± 13 years, 50% women) without prevalent AF from the community-based Prevention of Renal and Vascular End-stage Disease (PREVEND) study. By design of the PREVEND study, 70% of participants had a urinary albumin concentration >10 mg/L. Participants underwent 12-lead ECG screening at baseline and every 3 years. AF was considered screen-detected when first diagnosed during a study visit and clinically detected when first diagnosed during a hospital visit. We analysed data from the baseline visit (1997–1998) up to the third follow-up visit (2008). We used Cox regression with screen-detected and clinically detected AF as time-varying covariates to study the association of screen-detected and clinically detected AF with all-cause mortality, incident heart failure (HF) and vascular events.ResultsDuring a follow-up of 9.8 ± 2.3 years, 265 participants (3.2%) developed incident AF, of whom 60 (23%) had screen-detected AF. The majority of baseline characteristics were comparable between individuals with screen-detected and clinically detected AF. Unadjusted, both screen-detected and clinically detected AF were strongly associated with mortality, incident HF, and vascular events. After multivariable adjustment, screen-detected and clinically detected AF remained significantly associated with mortality (HR 2.21 (95% CI 1.09 to 4.47) vs 2.95 (2.18 to 4.00), p for difference=0.447) and incident HF (4.90 (2.28 to 10.57) vs 3.98 (2.49 to 6.34), p for difference=0.635). After adjustment, screen-detected AF was not significantly associated with vascular events, whereas clinically detected AF was (1.12 (0.46 to 2.71) vs 1.92 (1.21 to 3.06), p for difference=0.283).ConclusionScreen-detected incident AF was associated with an increased risk of adverse outcomes, especially all-cause mortality and incident HF. The risk of outcomes was not significantly different between screen-detected AF and clinically detected AF.
Gravitational waves from preheating in Gauss–Bonnet inflation
Authors: El Bourakadi K. , Ferricha-Alami M. , Filali H. , Sakhi Z. , Bennai M. 
Published: December 2021

AbstractWe study gravitational wave production in an expanding Universe during the first stages following inflation, and investigate the consequences of the Gauss–Bonnet term on the inflationary parameters for a power-law inflation model with a GB coupling term. Moreover, we perform the analyses on the preheating parameters involving the number of e-folds $$N_{pre}$$

N

pre

, and the temperature of thermalization $$T_{th},$$

T

th

,

and show that it’s sensitive to the parameters n, and $$\gamma $$
γ
, the parameter $$\gamma $$
γ
is proposed to connect the density energy at the end of inflation to the preheating energy density. We set a correlation of gravitational wave energy density spectrum with the spectral index $$n_{s}$$

n
s

detected by the cosmic microwave background experiments. The density spectrum $$\varOmega _{gw}$$

Ω

gw

shows good consistency with observation for $$\gamma =$$

γ
=

$$10^{3}$$

10
3

and $$10^{6}$$

10
6

. Our findings suggest that the generation of gravitational waves (GWs) during preheating can satisfy the constraints from Planck’s data.
Local-moves on knots and products of knots II
Authors: Kauffman Louis H. , Ogasa Eiji 
Published: December 2021

We use the terms, knot product and local-move, as defined in the text of this paper. Let [Formula: see text] be an integer [Formula: see text]. Let [Formula: see text] be the set of simple spherical [Formula: see text]-knots in [Formula: see text]. Let [Formula: see text] be an integer [Formula: see text]. We prove that the map [Formula: see text] is bijective, where [Formula: see text]Hopf, and Hopf denotes the Hopf link. Let [Formula: see text] and [Formula: see text] be 1-links in [Formula: see text]. Suppose that [Formula: see text] is obtained from [Formula: see text] by a single pass-move, which is a local-move on 1-links. Let [Formula: see text] be a positive integer. Let [Formula: see text] denote the knot product [Formula: see text]. We prove the following: The [Formula: see text]-dimensional submanifold [Formula: see text] [Formula: see text] is obtained from [Formula: see text] by a single [Formula: see text]-pass-move, which is a local-move on [Formula: see text]-submanifolds contained in [Formula: see text]. See the body of this paper for the definitions of all local-moves in this abstract. We prove the following: Let [Formula: see text], and [Formula: see text] be positive integers. If the [Formula: see text] torus link is pass-move-equivalent to the [Formula: see text] torus link, then the Brieskorn manifolds, [Formula: see text] and [Formula: see text], are diffeomorphic as abstract manifolds. Let [Formula: see text] and [Formula: see text] be (not necessarily connected or spherical) 2-dimensional closed oriented submanifolds in [Formula: see text]. Suppose that [Formula: see text] is obtained from [Formula: see text] by a single ribbon-move, which is a local-move on 2-dimensional submanifolds contained in [Formula: see text]. Let [Formula: see text] be an integer [Formula: see text]. We prove the following: The [Formula: see text]-submanifold [Formula: see text] [Formula: see text] is obtained from [Formula: see text] by a single [Formula: see text]-pass-move, which is a local-move on [Formula: see text]-dimensional submanifolds contained in [Formula: see text].
Auditable Augmented/Mixed/Virtual Reality
Authors: Cloete Richard , Norval Chris , Singh Jatinder 
Published: December 2021

Virtual, Augmented and Mixed Reality (XR) technologies are becoming increasingly pervasive. However, the contextual nature of XR, and its tight coupling of the digital and physical environments, brings real propensity for loss and harm.
This means that auditability---the ability to inspect how a system operates---will be crucial for dealing with incidents as they occur, by providing the information enabling rectification, repair and recourse. However, supporting audit in XR brings considerations, as the process of capturing audit data itself has implications and challenges, both for the application (e.g., overheads) and more broadly.
This paper explores the practicalities of auditing XR systems, characterises the tensions between audit and other considerations, and argues the need for flexible tools enabling the management of such. In doing so, we introduce Droiditor, a configurable open-source Android toolkit that enables the runtime capture of audit-relevant data from mobile applications. We use Droiditor as a means to indicate some potential implications of audit data capture, demonstrate how greater configurability can assist in managing audit-related concerns, and discuss the potential considerations that result. Given the societal demands for more transparent and accountable systems, our broader aim is to draw attention to auditability, highlighting tangible ways forward and areas for future work.
CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation
Authors: Rodrigues-Díez Raúl R. , Tejera-Muñoz Antonio , Esteban Vanesa , Steffensen Lasse B. , Rodrigues-Díez Raquel , Orejudo Macarena , Rayego-Mateos Sandra , Falke Lucas L. , Cannata-Ortiz Pablo , Ortiz Alberto , Egido Jesus , Mallat Ziad , Briones Ana M. , Bajo M. Auxiliadora , Goldschmeding Roel , Ruiz-Ortega Marta 
Published: December 2021

Background:
CCN2 (cellular communication network factor 2) is a matricellular protein involved in cell communication and microenvironmental signaling responses. CCN2 is known to be overexpressed in several cardiovascular diseases, but its role is not completely understood.

Methods:

Here, CCN2 involvement in aortic wall homeostasis and response to vascular injury was investigated in inducible
Ccn2
-deficient mice, with induction of vascular damage by infusion of Ang II (angiotensin II; 15 days), which is known to upregulate CCN2 expression in the aorta.

Results:

Ang II infusion in CCN2-silenced mice lead to 60% mortality within 10 days due to rapid development and rupture of aortic aneurysms, as evidenced by magnetic resonance imaging, echography, and histological examination.
Ccn2
deletion decreased systolic blood pressure and caused aortic structural and functional changes, including elastin layer disruption, smooth muscle cell alterations, augmented distensibility, and increased metalloproteinase activity, which were aggravated by Ang II administration. Gene ontology analysis of RNA sequencing data identified aldosterone biosynthesis as one of the most enriched terms in CCN2-deficient aortas. Consistently, treatment with the mineralocorticoid receptor antagonist spironolactone before and during Ang II infusion reduced aneurysm formation and mortality, underscoring the importance of the aldosterone pathway in Ang II–induced aorta pathology.

Conclusions:
CCN2 is critically involved in the functional and structural homeostasis of the aorta and in maintenance of its integrity under Ang II–induced stress, at least, in part, by disruption of the aldosterone pathway. Thus, this study opens new avenues to future studies in disorders associated to vascular pathologies.
Carotid Web Phenotype Is Uncommonly Associated With Classic Fibromuscular Dysplasia: A Retrospective Observational Study
Authors: Sharashidze Vera , Nogueira Raul G. , Al-Bayati Alhamza R. , Bhatt Nirav , Nahab Fadi B , Yun Johanna , Allen Jason W. , Frankel Michael , Haussen Diogo C 
Published: December 2021

Background and Purpose:
Carotid web (CaW) is an intimal form of fibromuscular dysplasia (FMD) involving the carotid bulb which has been increasingly recognized as a potential cause of recurrent ischemic strokes. It is overlooked as a separate entity and often dismissed if no coexistent signs of classic FMD changes are observed. We aim to evaluate the frequency of classic FMD in high-yield vascular territories in patients with symptomatic CaW.

Methods:
This was a retrospective analysis of a symptomatic CaW database of 2 comprehensive stroke centers (spanning September 2014–October 2020). The diagnosis of a CaW during a stroke workup was defined as the presence of a shelf-like linear filling defect in the posterior aspect of the carotid bulb on computed tomography angiography in patients with acute ischemic stroke or transient ischemic attack of undetermined cause after a thorough evaluation. Neck computed tomography angiography and renal conventional angiography images were independently evaluated by two readers blinded to the laterality and clinical details to inspect the presence of underlying classic FMD.

Results:
Sixty-six patients with CaW were identified. Median age was 51 years (interquartile range, 42–57), and 74% were women. All patients had neck computed tomography angiography (allowing for bilateral vertebral and carotid evaluation), whereas 47 patients had additional digital subtraction angiography (which evaluated 47 carotids ipsilateral to the stroke and 10 contralateral carotids). Internal carotid artery classic FMD changes were noted in only 6 out of 66 (9%) in the ipsilateral carotids. No contralateral carotid or vertebral artery classic FMD changes were observed. Renal artery catheter-based angiography was obtained in 16 patients/32 arteries and only 1 patient/2 renal arteries demonstrated classic FMD changes.

Conclusions:
CaW phenotype is uncommonly associated with classic FMD changes. Coexistent classic FMD does not constitute a useful marker to corroborate or exclude CaW diagnosis.
The Authorship of al-Risāla l-Ǧāmiʿa Re-Examined
Authors: Mattila Janne 
Published: December 2021

Abstract
Rasāʾil Iḫwān al-Ṣafāʾ and its summary, al-Risāla l-Ǧāmiʿa, are commonly attributed to the same authors. The strongest argument for this is the presence of references from the former to the latter. The aim of the present article is to analyze all of these references to establish their import for the theory of common authorship. When the fourteen references in the Beirut edition are compared with the oldest manuscripts, the result is that only six of these references appear in the latter, and even among these two are highly ambiguous. The only references from Rasāʾil Iḫwān al-Ṣafāʾ to al-Risāla l-Ǧāmiʿa unambiguously confirmed by the oldest manuscripts are the four references in version B of epistle 52, which is itself of dubious authenticity. Since all or most of the references outside epistle 52 are then clearly later interpolations, the conclusion is that the references in Rasāʾil Iḫwān al-Ṣafāʾ do not support the theory of common authorship.
Phanariot Tongues: The Mavrocordatos Family and the Power of the Turkish Language in the Eighteenth-Century Ottoman Empire
Authors: Shafir Nir 
Published: December 2021

Abstract
The Phanariots — Grecophone Christian elites who ruled the Danubian principalities in the eighteenth century — were the only non-Muslims in the Ottoman Empire who claimed power by virtue of their command of the Turkish language. Why were they the rare exception and what does their story reveal about the ways in which power and language were intertwined in the early modern Ottoman Empire? The implicit power relations embedded in the Turkish language are rendered visible in a unique text written in 1731 in which Constantine Mavrocordatos, a Phanariot prince, attempted to school his younger brother in Turkish through a series of twelve, play-like dialogues. The dialogues did not aim to teach the formal grammar of Turkish but to demonstrate the power of speech by familiarizing the reader with the eloquent and witty repartee of Ottoman bureaucrats. Through an analysis of the text — which includes reestablishing its authorship and date of composition — the article examines the Phanariots’ liminal position in Ottoman governance, especially in the newly ascendant imperial bureaucracy, through the prism of language. In doing so, it also rewrites the place of the Mavrocordatos family in the story of the Enlightenment in the Ottoman Empire.
Morpho-Semantic Evidence of Emerging Subjectivity in the Language of the Nahḍah — A Proposal
Authors: Guth Stephan 
Published: December 2021

Abstract
This article reviews some key concepts of the Arab(ic) Nahḍah with the aim of highlighting the usefulness of a more genuinely linguistic, i.e., grammar- and etymology-oriented approach for a deeper understanding of some basic features of the foundational period of Arab modernity. My contention and starting-point is that the Nahḍah was, among other things, an era in which the Arab subject came to sense its own agency. This is reflected not only in the many phenomena we are used to associate with the Nahḍah — the emergence of the intellectual, of critical journalism, of historicism, sentimentalism, new literary genres, etc. — but also in the morpho-semantics of key Nahḍah terminology. I argue (a) that the self-referential t-morpheme that features in many words signifying important Nahḍah concepts, such as taraqqī, taqaddum, or tamaddun, can and should be seen in the same light, i.e., as an indicator of a new emphasis on the self. Moreover, I argue that both the grammatical form of the new vocabulary (e.g., the -iyyah suffix for abstracts, verbal nouns, the causative patterns of form II and IV) and its “original”, “basic” (root) meanings underline (b) secularisation and the concomitant centrality of the human being, as well as (c) proactivity, energetic verve, and creativity, i.e., the subject’s being a cause of change in time (hence history). Thus, each new conceptual term is a little ‘Nahḍah in a nutshell,’ containing the very essence of Nahḍawi thought and the actual experience of feeling “modern”.
Observed and Modeled Urban Heat Island and Sea-Breeze Circulation Interactions: A Shanghai Case Study
Authors: Hu Yan , Tan Jianguo , Grimmond Sue , Ao Xiangyu , Yan Yafei , Liu Dongwei 
Published: December 2021

Abstract
Urban heat island (UHI) and sea–land-breeze systems are well-known and important characteristics of the climate of coastal cities. To model these, the accurate estimation of the surface energy balance (SEB) is a key factor needed to improve local-scale simulations of thermodynamic and dynamic boundary circulations. The Weather Research and Forecasting Model with a single-layer urban canopy model (WRF/SLUCM), with parameters derived from MODIS and local GIS information, is used to investigate the UHI and sea-breeze circulations (SBC) in the megacity of Shanghai. The WRF/SLUCM can reproduce observed urban radiation and SEB fluxes, near-surface meteorological variables, and the evolution of the UHI and SBC. Simulations for an August period show the maximum UHI tends to drift northwest in the afternoon, driven by the prevailing southeast wind. The sea breeze lasts for about 4 h and is strongest between 1200 and 1400 local time (UTC + 8 h). The interaction between UHI and SBC is evident with low-level convergence, upward motion, and moisture transport from the sea and urban breezes simulated. An urban circulation (horizontal/vertical/time scales: ∼20 km/∼1.5 km/∼3 h) with thermal vertical motions (∼1.5 m s−1) above the urban area and an SBC (horizontal/vertical/time scales: 6–7 km/∼1 km/2–3-h) above the northern coastal suburb occur. Combined the sea breeze and southerly winds form a low-level wind shear (convergence zone) ∼5 km from the coast that penetrates ∼20 km inland to the urban center. Using the WRF/SLUCM simulations we improve understanding of the complex spatial dynamics of summertime urban heating in coastal megacities, such as Shanghai.
Comparable Esophagectomy Outcomes by Surgeon Specialty: A NSQIP Analysis
Authors: Hsu Diana S. , Ely Sora , Gologorsky Rebecca C. , Rothenberg Kara A. , Banks Kian C. , Dominguez Dana A. , Chang Ching-Kuo , Velotta Jeffrey B. 
Published: December 2021

Background A few observational studies have found that outcomes after esophagectomies by thoracic surgeons are better than those by general surgeons. Methods Non-emergent esophagectomy cases were identified in the 2016-2017 American College of Surgeons NSQIP database. Associations between patient characteristics and outcomes by thoracic versus general surgeons were evaluated with univariate and multivariate logistic regression. Results Of 1,606 cases, 886 (55.2%) were performed by thoracic surgeons. Those patients differed from patients treated by general surgeons in race (other/unknown 19.3% vs 7.8%; P<.001) but not in other baseline characteristics (age, sex, BMI, and comorbidities). Thoracic surgeons performed an open approach more frequently (48.9% vs 30.8%, P<.001) and had operative times that were 30 minutes shorter (P<.001). General surgeons had lower rates of reoperation (11.8% vs 17.2%; P=.003) and were more likely to treat postoperative leak with interventional means (6.3% vs 3.4%, P=.01). Thoracic surgeons were more likely to treat postoperative leak with reoperation (5.9% vs 3.6%, P=.01). There were no other differences in univariate comparison of outcomes between the two groups, including leak, readmission, and death. General surgery specialty was associated with lower risk of reoperation. Our multivariable model also found no relationship between general surgeon and risk of any complication (odds ratio 1.10; 95% CI .86 to 1.42). Discussion In our large, national database study, we found that outcomes of esophagectomies by general surgeons were comparable with those by thoracic surgeons. General surgeons managed postoperative leaks differently than thoracic surgeons.