bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracted: Clinical Characteristics and Risk Factors Associated with Severe Disease Progression among COVID‐19 Patients In Wad Medani Isolation Centers: A Multicenter Retrospective Cross‐Sectional Study
Authors: Yousif Mohammed Yousif Elnaeem , Eljack Mohammed Mahmmoud Fadel Allah , Haroun Mazin S. , Abbasher Hussien Mohamed Ahmed Khabab , Amir Osman , Alfatih Mohammed , Al Shiekh Akram Khalid Al Tigany , Ahmed Mazin Abdelraham Osman , Nour Alshareef , Alhusseini Radi Tofaha , Osman Waddah Aljaely Mohammed , Abdulkarim Mohamed , Omer Mohammed Eltahier Abdalla , Mahgoub Ibrahim M. 
Published: March 2022

AbstractBackgroundSince December 2019, (COVID‐19) has had a significant impact on global health systems. Because little is known about the clinical characteristics and risk factors connected with COVID‐19 severity in Sudanese patients, it is vital to summarize the clinical characteristics of COVID‐19 patients and to investigate the risk factors linked to COVID‐19 severity.ObjectivesWe aimed to assess the clinical characteristics of COVID‐19 patients and look into risk factors associated with COVID‐19 severity.MethodsThis is a retrospective cross‐sectional study that took place in two Isolation Centers in Wad Medani, Gezira State, Sudan. Four hundred and eighteen patients were included between May 2020 and May 2021. All COVID‐19 patients over the age of 18 who were proven COVID‐19 positive by nucleic acid testing or had characteristics suggestive of COVID‐19 on a chest CT scan and had a complete medical record in the study period were included.ResultsThe participants in this study were 418 confirmed COVID‐19 cases with a median age of 66.313 years. There were 279 men (66.7%) among the patients. The most prevalent comorbidities were hypertension (n = 195; 46.7%) and diabetes (n = 187; 44.7%). Fever (n = 303; 72.5%), cough (n = 278; 66.5%), and dyspnea (n = 256; 61.2%) were the most prevalent symptoms at the onset of COVID‐19. The overall mortality rate (n = 148) was 35.4%. Patients with severe illness had a mortality rate of 42.3% (n = 118). Older age, anemia, neutrophilia, and lymphocytopenia, as well as higher glucose, HbA1c, and creatinine levels, were all linked to severe COVID‐19, according to the chi‐square test and analysis of variance analysis.ConclusionSixteen variables were found to be associated with COVID‐19 severity. These patients are more prone to go through a serious infection and as a result have a greater death rate than those who do not have these characteristics.
Peatland drainage alters soil structure and water retention properties: Implications for ecosystem function and management
Authors: Word Clayton S. , McLaughlin Daniel L. , Strahm Brian D. , Stewart Ryan D. , Varner J. Morgan , Wurster Frederic C. , Amestoy Trevor J. , Link Nicholas T. 
Published: February 2022

AbstractPeatland functions (e.g., carbon sequestration and flora diversity) are largely driven by soil moisture dynamics and thus dependent on interactions between hydrologic regimes and organic soil properties. Understanding these interactions is particularly important in drained peatlands, where drier conditions may alter soil properties with feedbacks to soil water retention and associated ecosystem functions. In this work, we focused on the Great Dismal Swamp (GDS) in Virginia, USA, a historically drained, temperate peatland with ongoing hydrologic restoration efforts. Two distinct soil layers varying in thickness exist at GDS: an upper layer with subangular blocky structure thought to be a result of past drainage, and a sapric lower layer with a massive structure more representative of an undisturbed state. To understand the occurrence and consequences of these distinct layers, we used continuous water table data and analysed soil physical and hydraulic properties to characterize soil profiles at 16 locations. We found significant differences between layer properties, where upper layers had lower fibre and organic matter contents and higher bulk densities. Further, moisture release curves demonstrated lower water retention in upper layers compared with lower layers and key differences in pore structure, with upper layers having higher macroporosity. Upper layers varied in thickness across sampling locations (~0.30 to 1.0 m) with a transition to lower soil layers typically occurring at depths below contemporary water level observations, suggesting that the upper layer may be a result of historical drainage and deeper water table conditions. Yet, upper layers with more frequent saturation exhibited higher water retention and lower macroporosity compared with drier upper layers, thus indicating potential recovery following re‐wetting efforts. These findings highlight how past drainage influences soil properties and water retention, with important implications for current management objectives at GDS and other drained peatland systems.
TAR DNA‐binding protein 43 oligomers in physiology and pathology
Authors: Lye Yuh Shen , Chen Yun‐Ru 
Published: March 2022

AbstractTAR DNA‐binding protein 43 (TDP‐43) is an RNA/DNA‐binding protein involved in RNA regulation and diseases. In 2006, TDP‐43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in both amyotrophic lateral sclerosis and frontotemporal lobar dementia. It also presents in a large portion of patients with Alzheimer's disease. TDP‐43 is prone to aggregate; however, the role of TDP‐43 oligomers remains poorly understood in both physiological and pathological conditions. In this review, we emphasize the role of oligomeric TDP‐43 in both physiological and pathological conditions and discuss the potential mechanisms of oligomer formation. Finally, we suggest therapeutic strategies against the TDP‐43 oligomers in neurodegenerative diseases.
Impact of a cardiology pharmacist‐led intervention on high‐intensity statin prescribing upon discharge after acute myocardial infarction
Authors: Montepara Courtney A , Oberst Cassidy E , Fyock Jordan O , Martin Hailey M , Noll Micaleigh D , Nemecek Branden D , Covvey Jordan R , Talreja Om N , Elston Colleen A 
Published: March 2022

AbstractIntroductionStandard of care after an acute myocardial infarction (AMI) includes high‐intensity statin therapy to lower the risk of future cardiovascular events. However, the use of high‐intensity statins post‐AMI remains suboptimal, presenting an opportunity for clinical pharmacist services to improve clinical care.ObjectiveTo evaluate the impact of a cardiology clinical pharmacist intervention upon the rate of high‐intensity statins issued at hospital discharge after AMI.MethodsThis was a single‐center, pre‐post study that included patients 18 to 75 years of age who were discharged from one investigative site with a primary diagnosis of AMI (as determined by ICD‐10 codes) between July 2019 to December 2020. The primary outcome was the proportion of patients prescribed high‐intensity statins, defined as atorvastatin 40 to 80 mg or rosuvastatin 20 to 40 mg daily, at discharge pre and postimplementation of a cardiology clinical pharmacist intervention. Patients were stratified into two groups for comparison: pre‐ (07/01/2019‐3/31/2020) and post‐ (04/01/2020‐12/31/2020) intervention, for which the latter included cardiology pharmacist‐driven communication and documentation via the electronic health record.ResultsA total of 418 patients were included: 223 (53.3%) preintervention and 195 (46.7%) postintervention. The overall cohort was approximately two‐thirds men and 90% Caucasian, with a mean ± SD age of 61.4 ± 9.7 years; the pre and postintervention groups were similar in terms of demographics. The rate of high‐intensity statin prescribing at discharge improved from 83.0% preintervention to 95.4% postintervention (P <.0001). A total of 9.9%, 1.8%, and 5.4% of patients in the preintervention group received moderate‐intensity, low‐intensity, or no statin at discharge, respectively, lowering to 3.1%, 1.0%, and 0.5% postintervention.ConclusionThere was a statistically significant increase in the rate of high‐intensity statin prescribing post‐AMI after the implementation of targeted cardiology clinical pharmacist services.
Tracking Strain-Specific Morphogenesis and Angiogenesis of Murine Calvaria with Large-Scale Optoacoustic and Ultrasound Microscopy
Authors: Li Weiye , Liu Yu-Hang , Estrada Héctor , Rebling Johannes , Reiss Michael , Galli Serena , Nombela-Arrieta César , Razansky Daniel 
Published: February 2022

ABSTRACTSkull bone development is a dynamic and well-coordinated process playing a key role in maturation and maintenance of the bone marrow (BM), fracture healing, and progression of diseases such as osteoarthritis or osteoporosis. At present, dynamic transformation of the growing bone (osteogenesis) as well as its vascularization (angiogenesis) remain largely unexplored due to the lack of suitable in vivo imaging techniques capable of noninvasive visualization of the whole developing calvaria at capillary-level resolution. We present a longitudinal study on skull bone development using ultrasound-aided large-scale optoacoustic microscopy (U-LSOM). Skull bone morphogenesis and microvascular growth patterns were monitored in three common mouse strains (C57BL/6J, CD-1, and Athymic Nude-Foxn1nu) at the whole-calvaria scale over a 3-month period. Strain-specific differences in skull development were revealed by quantitative analysis of bone and vessel parameters, indicating the coupling between angiogenesis and osteogenesis during skull bone growth in a minimally invasive and label-free manner. The method further enabled identifying BM-specific sinusoidal vessels, and superficial skull vessels penetrating into BM compartments. Our approach furnishes a new high-throughput longitudinal in vivo imaging platform to study morphological and vascular skull alterations in health and disease, shedding light on the critical links between blood vessel formation, skull growth, and regeneration. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Single‐cell RNA sequencing reveals the cell types heterogenicity of human discoid lateral meniscus cells
Authors: Sun Hao , Zhang Wenhui , Liu Fangzhou , Li Deng , Cai Zhiqing , Huang Zhencheng , Chen Meiyi , Lin Zhencan , Xu Jie , Ma Ruofan 
Published: February 2022

AbstractDiscoid lateral meniscus (DLM) is more prone to injury than a normally shaped meniscus. No study has compared the gene expression and cell heterogeneity between discoid and normal menisci. We aimed to identify specific cell clusters and their marker genes in discoid meniscus, thereby providing a theoretical basis for the treatment and etiology of DLM. ScRNA‐seq was used in DLM and osteoarthritis lateral meniscus (OAM) cells to identify cell subsets and their gene signatures. Pseudo‐time analysis and immunohistochemical staining were used to investigate the temporal and spatial distribution of DLM‐specific clusters. ScRNA‐seq identified nine clusters originating from DLM and OAM, composed of seven empirically defined populations and two novel populations specific to DLM, namely, the prehypertrophic chondrocyte 2 (PreHTC‐2) and regulatory chondrocyte (RegC‐2) populations. Single‐cell trajectory showed that RegC‐2 and PreHTC‐2 were mainly distributed in a specific cell fate, with the PreHTC‐2 marker gene HAPLN1 highly expressed at the end of this fate. Immunohistochemical staining showed that HAPLN1 + cells were mainly distributed in the white zone of DLM. Matrix metalloproteinase (MMP) variants were expressed in DLM and OAM, with MMP2 highly expressed in OAM‐dominant cell clusters, while MMP3 was highly expressed in DLM‐dominant cell clusters. We concluded that two novel cell clusters including PreHTC‐2 were identified using single‐cell sequencing, which were mainly distributed in the white areas of DLM. Differentiated MMP expression in the trajectory may be a possible mechanism of DLM formation.
Evaluation of the Efficacy of Dexmedetomidine as a Local Anesthetic Adjuvant in Children: A Meta‐Analysis of Randomized Controlled Trials
Authors: Sun Yan , Wu Zhilin , Sun ShuJun , Chen Rui , Dai Maosha , Dou Xiaoke , Lin Yun 
Published: February 2022

AbstractDexmedetomidine has been identified as a useful adjunct to improve the effect of nerve blocks in adults; however, its effect for children has not yet been fully investigated. This meta‐analysis aimed to evaluate the reliability and efficacy of dexmedetomidine as a local anesthetic adjunct for pediatric surgeries. Eligible studies were searched in Cochrane, Embase, PubMed, and CBM. RevMan 5.4 was used to assess the risk of bias of each study and perform statistical analysis. Stata 15.0 was used to evaluate the publication bias of primary outcomes. Thirteen randomized controlled trial (RCTs) involving 722 patients aged 6 months to 12 years were harvested. Statistical analysis showed that dexmedetomidine resulted in: a significantly longer duration of analgesia (standardized mean difference [SMD], 7.16; 95% confidence interval [95%CI], 4.88 to 9.43; P < .001; I2 = 98%); a reduction in the 1‐hour pain score (mean difference [MD], –0.27; 95%CI, –0.47 to –0.06; P = .01; I2 = 28%); cumulative doses of rescue analgesic required of 2 doses (risk ratio [RR], 0.26; 95%CI, 0.14 to 0.49; P < .001; I2 = 0) or 3 doses (RR, 0.04; 95%CI, 0.01 to 0.16; P < .001; I2 = 4%); the frequency of emergence agitation (RR, 0.44; 95%CI, 0.22 to 0.91; P = .03; I2 = 0); and a reduction in the onset time of blocks (mean difference –3.56; 95%CI, –6.39 to –0.74; P = .01; I2 = 90%). However, the incidence of some side effects, including hypotension, bradycardia, nausea and vomiting, pruritis, urinary retention, and respiratory depression, did not significantly differ between the dexmedetomidine group and the placebo group. Therefore, dexmedetomidine is a reliable and efficient adjunct to local anesthetics in children.
The necessary leadership skillsets for the high‐reliability organization framework adoption within acute healthcare organizations
Authors: Logan‐Athmer Amanda L. 
Published: March 2022

AbstractThis research explores the necessary leadership skills for the successful adoption of the High‐Reliability Organization (HRO) framework within acute healthcare organizations. Using a qualitative research design, organization leaders and experts at the executive, mid‐level, and front‐line levels were interviewed. The results were analyzed to correlate specific leadership skillsets and components to the most successful adoption strategies. In total, 20 skillsets were identified with seven representing data saturation. The seven vital skillsets include non‐hierarchical leadership, transparent and continuous communication, deference to expertise, ability to innovate, motivation through recognition, reflective of self, and commitment to visibility.
SARS‐COV‐2 genomic monitoring in the state of São Paulo unveils two emerging AY.43 sublineages
Authors: Lima Alex Ranieri Jerônimo , Ribeiro Gabriela , Viala Vincent Louis , de Lima Loyze Paola Oliveira , Martins Antonio Jorge , Barros Claudia Renata dos Santos , Marqueze Elaine Cristina , Bernardino Jardelina de Souza Todao , Moretti Debora Botequio , Rodrigues Evandra Strazza , Santos Elaine Vieira , Brassaloti Ricardo Augusto , Cassano Raquel de Lello Rocha Campos , Mariani Pilar Drummond Sampaio Corrêa , Clemente Luan Gaspar , Assato Patricia Akemi , Costa Felipe Allan da Silva da , Poleti Mirele Daiana , Lesbon Jessika Cristina Chagas , Mattos Elisangela Chicaroni , Banho Cecilia Artico , Sacchetto Lívia , Moraes Marília Mazzi , Palmieri Melissa , Martininghi Maiara , Caldeira Luiz Artur Vieira ,  Silva Fabiana Erica Vilanova da , Grotto Rejane Maria Tommasini , Souza‐Neto Jayme A. , Giovanetti Marta , Junior Alcantara Luiz Carlos , Nogueira Maurício Lacerda , Fukumasu Heidge , Coutinho Luiz Lehmann , Kashima Simone , Neto Raul Machado , Covas Dimas Tadeu , Slavov Svetoslav Nanev , Sampaio Sandra Coccuzzo , Elias Maria Carolina 
Published: March 2022

AbstractDelta VOC is highly diverse with more than 120 sublineages already described as of November 30, 2021. In this study, through active monitoring of circulating severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) variants in the state of São Paulo, southeast Brazil, we identified two emerging sublineages from the ancestral AY.43 strain which were classified as AY.43.1 and AY.43.2. These sublineages were defined by the following characteristic nonsynonymous mutations ORF1ab:A4133V and ORF3a:T14I for the AY.43.1 and ORF1ab:G1155C for the AY.43.2 and our analysis reveals that they might have a likely‐Brazilian origin. Much is still unknown regarding their dissemination in the state of São Paulo and Brazil as well as their potential impact on the ongoing vaccination process. However, the results obtained in this study reinforce the importance of genomic surveillance activity for timely identification of emerging SARS‐CoV‐2 variants which can impact the ongoing SARS‐CoV‐2 vaccination and public health policies.
Correlation between knee anatomy and joint laxity using principal component analysis
Authors: Shalhoub Sami , Cyr Adam , Maletsky Lorin P. 
Published: February 2022

AbstractKnee articular geometry and surface morphology greatly affect knee joint mechanics. Intra‐subject variations in bone morphology and the passive range of motion have been well documented in the literature; however, the relationship between these two characteristics is not well understood. The objective of this study was to describe the correlation between knee joint anatomical features and passive range of motion using a statistical model. A principal component model was developed using femoral and tibial articular geometry, knee joint initial stance position, and the passive laxity envelope obtained from 27 cadaveric knees. The results from the principal component analysis showed high correlation between the anatomical features and the tibiofemoral passive envelope; an increase in the average femoral condyle radii, an increase in slope of the tibial spine, and a higher tibial plateau concavity correlated with a decrease in varus−valgus and internal−external range of motion. Understanding the correlation between anatomical features and tibiofemoral laxity could aid in the development of orthopedic implant designs by quantifying the effect of perturbing specific anatomical features on knee laxity and identifying specific implant femoral and tibial articular geometry necessary to obtain a targeted passive range of motion.
Riboflavin as a green sorbent in dispersive micro‐solid‐phase extraction of several pesticides from fruit juices combined with dispersive liquid–liquid microextraction
Authors: Abbasalizadeh Aysa , Sorouraddin Saeed Mohammad , Farajzadeh Mir Ali , Marzi Elnaz , Afshar Mogaddam Mohammad Reza 
Published: February 2022

AbstractA vortex‐assisted dispersive micro‐solid‐phase extraction procedure using a new and green sorbent was developed as a simple, fast, and efficient sample preparation method for the extracting five pesticides in several fruit juice samples. In this study, for the first time, riboflavin was used as an efficient sorbent. A few milligrams of riboflavin was directly added into the aqueous solution containing the analytes to adsorb them. After adsorption the analytes, they were desorbed and more concentrated by a dispersive liquid–liquid microextraction procedure. The influence of several effective parameters such as amount of riboflavin, pH, vortex time, eluent nature and volume, and extraction solvent type and volume on the extraction efficiency was investigated. In optimal conditions, linear ranges of the calibration curves were broad. The limits of detection and quantification were attained in the ranges of 0.56–1.5 and 1.9–0.52 ng mL−1, respectively. The proposed method demonstrated to be suitable for concurrent extraction of the studied pesticides in various fruit juice samples with high enrichment factors (320–360) and precision (relative standard deviation ≤7.8% for intra‐ [n = 6] and interday [n = 4] precisions at a concentration of 25 ng mL−1 of each pesticide).
Kinetics study of CO2 absorption into methyldiethanolamine, potassium lysinate, and their blends in aqueous solution
Authors: Ramezani Rouzbeh , Di Felice Renzo 
Published: February 2022

AbstractIn this work, the kinetics for the reaction of CO2 with three chemical solvents were studied experimentally and theoretically. The CO2 absorption flux into the potassium lysinate (K‐Lys), methyldiethanolamine (MDEA), and their blends was measured over the CO2 partial pressure range of 50–500 kPa, and at temperatures 298.15, 303.15, and 313.15 K using a stirred cell reactor. The effect of the addition of K‐Lys on the absorption flux of CO2 into MDEA solution at low and high pressure was investigated. The reaction kinetics of CO2 absorption in CO2‐loaded MDEA, K‐Lys, and MDEA + K‐Lys solutions were also examined and absorption flux of CO2 as a function of CO2 loading was determined. The values of CO2 diffusivity, viscosity, the liquid mass transfer coefficient, the overall reaction rate constant, and the physical solubility of CO2 into MDEA + K‐Lys solution were reported. Furthermore, a standard kinetics model was developed to describe the CO2 absorption behavior in the solution at low and high pressures, for both unloaded and CO2‐loaded systems.
Organic amendments facilitate soil carbon sequestration via organic carbon accumulation and mitigation of inorganic carbon loss
Authors: Tian Yanfang , Wang Qiqi , Gao Wei , Luo Yu , Wu Lei , Rui Yichao , Huang Yaping , Xiao Qiong , Li Xin , Zhang Wenju 
Published: February 2022

AbstractBoth soil organic carbon (SOC) and soil inorganic carbon (SIC) are important carbon reservoirs involved in the global carbon cycle. Fertilization especially organic amendments can increase SOC sequestration, while nitrogen fertilization‐induced soil acidification leads to significant SIC loss in alkline soil. How fertilization changes SIC and SOC via altering abiotic and biotic properties remains unclear. Here, we investigated the effects of mineral fertilizer with/without organic amendments (manure, straw, green manure) on SIC and SOC in bulk soil and particle‐size fractions, as well as their interrelationship based on a 38‐year field trial. Results showed that compared to the unfertilized soil, mineral fertilization significantly decreased SIC by 13.38%–15.69%, primarily due to decreased soil pH. However, mineral nitrogen plus manure (NM) largely increased SIC by 26.55%, likely resulting from the reprecipitated by Ca2+ and/or Mg2+ compensation. Mineral nitrogen plus manure and straw (NM, NS) increased SOC by 11.12%–100.35%. For bulk soil and particle‐size fractions >0.25 mm, SIC content was positively correlated with SOC. Random forest model revealed that SOC was regulated by soil nutrients (total nitrogen [TN], Olsen‐P), microbial biomass and β‐1,4‐N‐acetyl‐glucosaminidase. The change in SIC was directly regulated by soil Mg2+, and indirectly by soil nutrients (e.g., TN, Olsen‐P) which affected crop‐derived C input. Our findings suggested that organic manure amendments can facilitate SOC accumulation and mitigate SIC loss by occluded more SIC in large soil particles. The results are of fundamental significance for understanding the role of optimal manure application played in SOC sequestration and SIC accumulation.