bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of thyroid function with insulin resistance: data from two population-based studies
Authors: Spira Dominik , Buchmann Nikolaus , Dörr Marcus , Markus Marcello R P , Nauck Matthias , Schipf Sabine , Spranger Joachim , Demuth Ilja , Steinhagen-Thiessen Elisabeth , Völzke Henry , Ittermann Till 
Published: January 2022

Objective
Thyroid dysfunction is associated with relevant disturbances in glucose metabolism. Moreover, thyroid function undergoes important changes with ageing. The objective of this study was to investigate the association of thyroid function with insulin resistance with particular consideration of possible age-related effect modifications.

Design
A sample of 4193 participants from two independent epidemiological studies, the Study of Health in Pomerania-TREND-0 and the Berlin Aging Study II, was included in this cross-sectional analysis.

Methods
Insulin resistance was estimated by homeostasis model of insulin resistance (HOMA-IR) and the insulin sensitivity index (ISI). Associations of thyroid biomarkers (thyroid-stimulating hormone, free thyroxine, and free triiodothyronine (fT3)) with parameters of glucose metabolism were analysed by regression models adjusted for age, sex, smoking status, and study site.

Results
A higher fT3 was significantly associated with higher fasting glucose and higher fasting and 2-h postload insulin levels, a higher HOMA-IR, and lower ISI. A higher fT3 was also associated with a higher risk for impaired fasting glucose (RR 1.09, 95 CI 1.02; 1.18; P  = 0.017). Many of these associations between thyroid markers and parameters of glucose metabolism were significant in young and middle-aged participants but not in older individuals.

Conclusions
The main finding of this study was a consistent association of fT3 with almost all markers of insulin resistance. However, this effect seems to be wearing off in higher age highlighting a potential age-related modification of the interaction between thyroid function and glucose metabolism. Further studies are needed to clarify causal relationships.
Criterion of the best non-symmetric approximant for multivariable functions in space $L_{1, p_2,...,p_n}$
Authors: Tkachenko M.Ye. , Traktynska V.M. 
Published: January 2022

The criterion of the best non-symmetric approximant for $n$-variable functions in the space $L_{1, p_2,...,p_n}$ $(1<p_i<+\infty , i=2,3,...,n)$ with $(\alpha ,\beta )$-norm$$\|f\|_{1,p_2,...,p_n;\alpha,\beta}=\left[\int\limits_{a_n}^{b_n}\cdots\left[\int\limits_{a_2}^{b_2}\left[\int\limits_{a_1}^{b_1} |f(x)|_{\alpha,\beta} dx_1\right]^{p_2} dx_2\right]^{\frac{p_3}{p_2}}\cdots dx_n\right]^{\frac{1}{p_n}},$$where $0<\alpha,\beta<\infty$, $\ f_{+}(x)=\max\{f(x),0\},\ f_{-}(x)=\max\{-f(x),0\},$ $\mathrm{sgn}_{\alpha,\beta}f(x)=\alpha\cdot\mathrm{sgn}f_{+}(x)-\beta\cdot\mathrm{sgn}f_{-}(x),$ $|f|_{\alpha,\beta}=\alpha \cdot f_{+}+\beta \cdot f_{-} =f(x)\cdot \mathrm{sgn}_{\alpha,\beta}f(x)$, is obtained in the article.It is proved that if $P_m=\sum\limits_{k=1}^{m}c_k\varphi_k$, where $\{\varphi_k\}_{k=1}^m$ is a linearly independent system functions of $L_{1,p_2,...,p_n}$, $c_k$ are real numbers, then the polynomial $P_m^{\ast}$ is the best $(\alpha ,\beta )$-approximant for $f$ in the space $L_{1,p_2,...,p_n}$ $(1<p_i<\infty $, $i=2,3,...,n)$, if and only if, for any polynomial $P_m$$$\int \limits_K P_m\cdot F_0^{\ast}dx \leq \int \limits_{a_n}^{b_n}...\int \limits_{a_2}^{b_2}\int \limits_{e_{x_2,...,x_n}}|P_m|_{\beta , \alpha}dx_1 \cdot \operatorname *{ess \,sup}_ {x_1 \in [a_1,b_1]} |F_0^{\ast}|_{\frac{1}{\alpha },\frac{1}{\beta }} dx_2...dx_n,$$where $K=[a_1,b_1]\times \ldots\times [a_n,b_n],$ $e_{x_2,...,x_n}=\{ x_1\in [a_1,b_1] : f-P_m^{\ast}=0\},$$$F_0^{\ast}=\frac{|R_m^{\ast}|_{1; \alpha ,\beta }^{p_2-1}|R_m^{\ast}|_{1,p_2; \alpha ,\beta }^{p_3-p_2}\cdot ... \cdot |R_m^{\ast}|_{1,p_2,...,p_{n-1}; \alpha ,\beta }^{p_n-p_{n-1}}\mathrm{sgn}_{\alpha ,\beta} R_m^{\ast}}{||R_m^{\ast}||_{1,p_2,...,p_n; \alpha ,\beta}^{p_n-1}},$$|f|_{p_k,\ldots,p_i;\alpha,\beta}=\left[\int\limits_{a_i}^{b_i}\ldots\left[ \int\limits_{a_{k+1}}^{b_{k+1}}\left[\int\limits_{a_k}^{b_k}|f|_{\alpha,\beta}^{p_k}dx_k\right]^{\frac{p_{k+1}}{p_k}}dx_{k+1} \right]^{\frac{p_{k+2}}{p_{k+1}}}\ldots dx_i \right]^{\frac{1}{p_i}},$$($1\leq k<i\leq n$), $R_m^{\ast}=f-P_m^{\ast}$.This criterion is a generalization of the known Smirnov's criterion for functions of two variables, when $\alpha =\beta =1$.
Knowledge management model for decision-making through ontologies for an employment and employability observatory
Authors: Méndez Beltrán David Alfonso , Prieto Suarez Duvan Humberto , Alvarado Nieto Luz Deicy 
Published: January 2022

Introduction: This article is the product of the research "Knowledge management model for decision-making through ontologies for an employment and employability observatory" developed within the ComplexUD Research Group in the Universidad Distrital Francisco José de Caldas between 2018 and 2020.
Objective: The objective of this research is the construction of a knowledge management model using ontologies of the actors involved in the employability process.
Methodology: The construction of knowledge was carried out through the creation of ontologies, which describe the conceptual components of each actor that participates in employability, since their interaction forms the proposed model.
Conclusion: It is observed that representing the actors through ontologies allows the behavior among them to be modeled in a way that is very close to reality, however, it must be taken into account that the components that describe the actors can change over time, for what is necessary a periodic update of the model.
Originality: This document proposes original ideas regarding the definition and behavior of the actors identified in the development of the research, if the work of other authors is mentioned throughout the article, it is cited according to the norms established by its publication.
Dynamic Cybersecurity Model based on ISO standards for Higher Education Institutions in Colombia
Authors: Varona Taborda María Alejandra 
Published: January 2022

Introduction: This article is the result of a research process whose product was to generate a guide for Higher Education Institutions (in Spanish, IES) to adopt a Cybersecurity Model based on ISO standards (International Organization for Standardization).
Problem: IES do not have a cybersecurity model aligned to the ISO / IEC 27032: 2012 standard (International Organization for Standardization / International Electrotechnical Commission), which causes a lack of clarity and uncertainty in the level of maturity and low efficiency in processes and information security controls to be implemented.
Objective: Propose a dynamic model of cybersecurity based on ISO standards for IES.
Methodology: The development of this work was oriented under a line of applied research, by virtue of the fact that it was necessary to address the problem based on previous knowledge that allowed supporting the theoretical contributions and the activities proposed to determine the possible causes of the problem and give it a possible solution.
Results: The generation of this dynamic model allows it to be adapted to the different needs and requirements of IES.
Conclusion: IES can implement a cybersecurity model to prevent and protect information at the cyberspace level.
Originality: The work carried out generates a great contribution, which is the generation of a dynamic cybersecurity model, since at present there are no specific models for IES.
Limitations: The model implementation guide is established in a general way to be applied later to an organization in any sector.
Keywords: Dynamic Cybersecurity Model, Higher Education Institutions, ISO/IEC 27032: 2012, Security Standards.
Message from the editor in chief
Authors: Ozcinar Zehra 
Published: January 2022

Greetings to our dear readers.
We are elated to share with all our readers, Vol. 7 No. 2 (2020) publication of our highly read International Journal of Innovative Research in Education (IJIRE). As has been our custom, as a highly read journal, we maintain a high standard in our published articles, and we have maintained our standard once again in this current issue. This publication aimed to publish high-standard articles that reflect current issues in education as a result of the COVID-19 pandemic.
This issue presents three selected papers from skilled researchers from Argentina, Iran, and Romania. The selected topics include the following: A semester of home-classroom, Online language teacher training – Challenges and new perspectives, The correlation between teacher's personality and level of student's anxiety. These papers reflect current issues as a result of the COVID-19 pandemic.
We are once again pleased with the researchers, reviewers, and publishing team that made this publication a success. We would therefore like to commend them for their immense contribution.
Dear reader, enjoy reading!!
Best Regards,
Assoc. Prof. Dr. Zehra Ozcinar Teacher Training Academy,
Editor-in-chief.
Message from the editor in chief
Authors: Ozcinar Zehra 
Published: January 2022

Greetings, dear readers.
We are thrilled to share with you, Volume 8 No. 1 (2020), publication of our highly acclaimed International Journal of Innovative Research in Education (IJIRE). This publication aims to present current approaches used in the learning and teaching process in education. The reviewers carefully selected high quality articles based on this aim.
After a careful review process, three papers were selected, representing topics from Morocco, North Cyprus and India. The selected topics include the following: The diagnosis methods for the obstacles and difficulties in computer sciences of nursing students; Investigation of the cognitive, psychomotor, and social emotional progress in primary schools by directors’ ideas; Semi supervised machine learning approach for DDOS detection.
We are delighted by the content of this issue and as such, we would like to thank all the contributors who made this publication a success. Dear reader, enjoy reading!!
Best Regards
Assoc. Prof. Dr. Zehra Ozcinar Teacher Training Academy,
Editor-in-chief
In cats which treatment, meloxicam or prednisolone, most quickly reduces clinical signs of feline interstitial cystitis?
Authors: Smith-Uchotski Thomas 
Published: January 2022

PICO question
In cats with feline interstitial cystitis, which therapy brings a faster resolution of clinical signs: meloxicam or prednisolone?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Two papers evaluated as relevant to the PICO question were critically reviewed. Both were double-blinded randomised controlled trials.
One paper not related to the PICO question, a single-blinded randomised controlled trial, was also reviewed as it is touched upon in the discussion section
Strength of evidence
Appraisal of the literature reveals weak evidence that meloxicam and prednisolone are of equivalent effectiveness when treating feline interstitial cystitis, also known as feline idiopathic cystitis (FIC)
Outcomes reported
There is no statistically significant difference in the reduction of clinical signs when meloxicam is compared with a placebo for the treatment of FIC. There is no statistically significant difference in reduction of clinical signs when prednisolone is compared with a placebo for the treatment of FIC. No studies were available for review which directly compared meloxicam against prednisolone as treatment options for FIC
Conclusion
In cats with FIC, insufficient evidence exists to truly conclude whether meloxicam or prednisolone is the most efficacious therapy for the reduction of clinical signs. Two double-blinded randomised controlled trials were evaluated – one compared the efficacy of meloxicam against a placebo; the other compared the efficacy of prednisolone against a placebo. Neither study found a statistically significant difference between the assessed treatment modality and the placebo used in reducing the clinical signs of FIC. As such, weak evidence exists that there is no significant difference between the use of meloxicam and a placebo, and prednisolone and a placebo in the reduction of clinical signs of FIC. Additionally, it could therefore be hypothesised that no significant difference exists in the reduction of clinical signs when comparing meloxicam against prednisolone as treatments for FIC however, no study was discoverable which was able to substantiate this claim

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
ODNOS GLAGOLSKIH PREFIKSA POD- I NAD-
Authors: Ajdžanović Jelena 
Published: January 2022

Predmet ovoga rada jeste analiza odnosa prefiksa pod- i nad- s ciljem da se utvrdi u kojim semantičkim realizacijama oni čine antonimski par, pri čemu se određuje o kojem se tipu antonimijskog odnosa radi. Da bi se proverilo sintaksičko ponašanje glagola deriviranih analiziranim antonimičnim prefiksima, sagledava se njihova argumentna struktura. Polazimo od pretpostavke da, premda označavaju suprotnost, derivirani glagoli kao predikati suštinski denotiraju situacije sa istim učesnicima, ali moguće drugačije formalizovanim.
Estimasi Parameter Model Gravity dengan Metode Penaksiran Kuadrat Terkecil dan Fungsi Hambatan Eksponensial-Negatif (Studi Kasus Kabupaten Sukoharjo)
Authors: Rum Josephin Onesifera 
Published: January 2022

<div class="WordSection1"><p>Kabupaten Sukoharjo memiliki lokasi yang strategis, yakni letaknya di persimpangan Semarang, Yogyakarta, dan Surakarta. Hal ini akan mendukung pembangunan di Kabupaten Sukoharjo, dan meningkatkan pergerakan. Pergerakan yang meningkat menimbulkan masalah transportasi, oleh karena itu diperlukan perencanaan dengan mengestimasi matriks asal tujuan. Hasil akhir penelitian ini diharapkan dapat diketahui besarnya parameter β pada fungsi hambatan Eksponensial-Negatif dengan metode Kuadrat Terkecil, untuk mengetahui total estimasi distribusi pergerakan di Kabupaten Sukoharjo pada tahun 2021, serta menguji tingkat kemiripan arus lalu lintas hasil pemodelan dan hasil <em>traffic count</em>. Perhitungan estimasi distribusi pergerakan tahun mendatang menggunakan Model <em>Gravity</em>. Nilai parameter β dalam persamaan model <em>Gravity </em>didapatkan melalui kalibrasi Newton-Raphson pada <em>software</em> Matlab. Untuk mengukur tingkat kemiripan dari perhitungan arus lalu lintas hasil pemodelan dan hasil <em>traffic count</em> digunakan Koefisien Determinasi. Hasil dari penelitian ini didapatkan nilai parameter β sebesar 0,0613, dengan total pergerakan Kabupaten Sukoharjo pada tahun 2021 adalah 16364 smp/jam. Tingkat validitas dari penelitian ini dianggap sangat tinggi karena didapatkan nilai R<sup>2</sup> senilai 0,8194.</p><p><strong>Kata Kunci :</strong> EMME/3, Matriks Asal Tujuan, Matlab, Model <em>Gravity</em></p></div><em><br clear="all" /></em>
Kajian Kuat Tarik Langsung dan Kuat Tarik Belah Beton Memadat Mandiri dengan Kadar Fly Ash 50%, 60%, dan 70% sebagai Pengganti Binder Terhadap Beton Normal
Authors: Istanto Ardha Teo 
Published: January 2022

<p>Dunia konstruksi terus berkembang semakin pesat, berbagai inovasi dilakukan dengan prinsip berkelanjutan dan ramah lingkungan. Salah satu inovasi beton ramah lingkungan yang dilakukan adalah menggunakan material <em>fly ash </em>sebagai pengganti semen pada beton <em>SCC</em><em> </em>yang dapat mengalir sendiri melewati celah besi tulangan yang rapat dan memenuhi ruangan tanpa memerlukan bantuan. Penelitian ini mengkaji bagaimana perbandingan besarnya nilai kuat tarik langsung, kuat tarik belah, dan kuat tekan pada beton <em>HVFAC</em><em>-</em><em>SCC </em>dibandingkan dengan beton normal<em>.</em> Pengujian kuat tarik langsung menggunakan benda uji balok 10 x 10 x 25 cm sedangkan pada pengujian kuat tarik belah dan kuat tekan berbentuk silinder dengan diameter 15 cm dan tinggi 30 cm. Hasil penelitian ini menyimpulkan bahwa kuat tarik langsung dan kuat tarik belah sama-sama memiliki nilai lebih kecil dari kuat tekan, nilai perbandingan kuat tarik langsung sebesar 11% dari kuat tekan, dan kuat tarik belah sebesar 8% dari kuat tekan beton.</p><p> </p><div id="gtx-trans" style="position: absolute; left: -7px; top: 185.4px;"> </div>
The Impact of Murotal Al-Qur’an on Decreasing Labor Pain In Maternity Mother First Phase
Authors: Argaheni Niken Bayu , Sukamto Ika Sumiyarsi , Nugraheni Angesti , Novika Revi Gama Hatta , Nurhidayati Siti , Sari Atriany Nilam , Kusmawati Iffah Indri , Maulida Luluk Fajria , Wahidah Nurul Jannatul , Maulina Rufidah , Putri Noviyati Rahardjo 
Published: January 2022

<p><em>Background: Murottal Al-Qur'an therapy is a therapy for reading Al-Qur'an which is a religious therapy in which a person is recited verses from the Qur'an for a few minutes or hours so that it has a positive impact on one's body. Murottal Al-Qur'an recitation as a remedy for physical ailments. The aim of the study: To see the effect of murottal Al-Qur'an therapy on reducing the intensity of pain during labor. Method: Systematic review using the database: Google Scholar. The search results that meet the criteria are then analyzed the articles. Results: Pain in labor from many factors: 1) Anxiety and Stress, 2) Supporting Environment and Individuals, 3). Number of Deliveries and 4) Subjective Experience. Conclusion: There is an effect of offering murottal Al-Qur'an therapy on reducing pain intensity, where mothers who give birth after receiving Murottal Al-Qur'an therapy have a lower pain scale than mothers who give birth before getting Murottal Al-Qur'an therapy.</em></p><p> </p>
Istikhdām Mauqi’ Wib Ikhtibār al-Kitābah al-‘Arabiyah fī Ta’līm Mahārah al-Kitābah Qism Ta'līm al-Lughah al-'Arabiyyah bi Jāmi’ah Muḥammadiyah Malang
Authors: Afifah Nor , Aulannisa Farah , Rosyidi Abdul Wahab , Taufiqurrohman Taufiqurrohman 
Published: January 2022

<p dir="RTL" align="center"><em>The pandemic condition due to the corona virus has changed the education system which is generally done face-to-face, now it must be done virtually by utilizing online media, one of which is a website. The purpose of this study is to describe 1) How to use the Arabic Typing Test website in learning writing skills at the University of Muhammadiyah Malang. 2) How is the effectiveness of using the Arabic Typing Test website in learning Maharoh Kitabah at the University of Muhammadiyah Malang. The method used in this study is an experimental method with a quantitative approach to measure the effectiveness of the Arabic typing test website. Respondents in this study were second semester students of Arabic language education study program, Islamic religious faculty, University of Muhammadiyah Malang. The data collection used in the form of interviews, observations, questionnaires and tests. The use of the Arabic Typing Test Website in learning writing skills at UMM is effective. The results of this study are that there are 3 stages of using the websie arabic typing test: 1) preparing a computer connected to the internet, 2) instructing students to enter the website with the address http://ajher.co.id, 3) registering using gmail and choose login. And the use of the Website Arabic typing test in learning maharah kitabah at the University of Muhammadiyah Malang is effective. </em></p><p dir="RTL"> </p>
Go-Jek Motor Driver's Patience and Work Commitment
Authors: Qodariah Siti , Fikriana Tanti Amalia , Putera Andy , Yasmin Savitri 
Published: January 2022

The online-based transportation is very helpful for people in doing activities. Besides being easy to reach, online transportation also offers cheap and fast prices. One company that develops online transportation is Go-Jek. The presence of Go-jek is a negative thing for conventional transportation services., Conventional transportation drivers conduct large-scale demonstrations until anarchic action against Go-Jek drivers. Although there are problems on the road, Go-Jek drivers committed to the company in carrying out their duties. With these problems, Go-Jek drivers are required to be patient, they persevere to keep working. This is interesting to study. Therefore this research is important to do, because it aims to see how patience and work commitment of Go-Jek drivers. The sample of research subjects was 95 people. The results of this study indicate that most Go-Jek motorcycle drivers have a low level of patience and work commitment
Upper respiratory infection and seasonal variations in the occurrence of in South Korea
Authors: Jung Yong Wook , Kim Eui-hyeok , Lee Sang Ah , Min Seunggi 
Published: January 2022

Abstract
The aim of this study was to examine the effect of seasonal changes on the incidence of preeclampsia in Asian regions and populations, and to evaluate the relationship between upper respiratory infection during pregnancy and the development of preeclampsia. This was a cohort study of women who delivered singletons between 2012 and 2018 in South Korea. A total of 548080 first singleton births were included for analysis. A total of 9,311 patients (1.70%) were diagnosed with preeclampsia. Multivariate analysis showed that older age (≥30 years old), low income, residing in the southern area of Korea, history of smoking, history of heavy drinking, higher body mass index, hypertension, or diabetes mellitus were risk factors for PE. Univariate analysis showed that upper respiratory infection was associated with the incidence of preeclampsia (P=0.0294). However, this association was not maintained in the multivariate analysis (aOR, 1.01; 95% CI, 0.95 - 1.07). After adjusting for confounding variables, the occurrence of PE was the highest in December (aOR, 1.21; 95%CI, 1.10-1.34) and lowest in July and August. This study demonstrated that there are seasonal variations in the occurrence of preeclampsia in Korea. Moreover, upper respiratory infection may be associated with the development of PE.
Pollution Characteristics And Health Risk Assessment of Phthalate Esters In Household Dust In Chengdu, China
Authors: Li Han-Han , Chen Liu-Jun , Yang Zhan-Biao , Xu Xiao-Xun , Xian Jun-Ren , Zhao Liu-Lan , Yang Song , cheng zhang 
Published: January 2022

Abstract
The characteristics and health risks of 15 phthalate esters in household dust and the association with household attributes were investigated in Chengdu, China. The concentrations of total phthalate esters ranged from 87.9 to 3623 μg/g. Di (2-ethylhexyl) phthalate (DEHP) was the dominant compound of phthalate esters with a median of 151 μg/g. The statistical analysis result showed household products and synthetic polymer emission were the main sources of phthalate esters. Smoking, cooking, keeping pets and the use of wooden floor and plastic wallpaper might increase the concentrations of phthalate esters in household dust, but opening windows frequently, and increasing the sweeping frequency might cause the decrease of phthalate esters in the indoor environment. The hazard indexes (HI) values of phthalate esters were all below 1, showed no non-carcinogenic for inhabitants. However, the carcinogenic risk of DEHP was 2.54 ×10-6, implying the carcinogenic risks via exposure to DEHP from Chengdu household dust were noticeable.