bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNVF-Memorandum Versorgungsforschung im letzten
Lebensjahr
Authors: Kremeike Kerstin , Bausewein Claudia , Freytag Antje , Junghanss Christian , Marx Gabriella , Schnakenberg Rieke , Schneider Nils , Schulz Holger , Wedding Ulrich , Voltz Raymond 
Published: October 2022

ZusammenfassungVersorgungsforschung im letzten Lebensjahr beschäftigt sich mit der
wissenschaftlichen Erfassung der Begleitung und Betreuung von schwerstkranken
und sterbenden Menschen sowie ihrer An- und Zugehörigen. Patientinnen
und Patienten in der letzten Lebensphase können unterschiedlichen
Erkrankungsgruppen angehören, besondere Charakteristika aufweisen
(z. B. Menschen mit kognitiver und komplexer Beeinträchtigung,
ökonomischer Benachteiligung oder Migrationshintergrund) sowie in
bestimmten Lebensphasen sein (z. B. Eltern minderjähriger
Kinder, (hohes) Alter). Aus der besonderen Situation der Betroffenen sowie aus
den Besonderheiten der Versorgung im letzten Lebensjahr ergibt sich das
Erfordernis für ein eigenes Memorandum zur Versorgungsforschung in
dieser Lebensphase. Dieses Memorandum beschreibt diesbezüglich ethische
und methodische Spezifika sowie aktuelle Fragestellungen der
Versorgungsforschung und wie diese angemessen mittels quantitativer,
qualitativer und gemischter Methoden bearbeitet werden können. Es wurde
von der Fachgruppe Palliativmedizin des Deutschen Netzwerk für
Versorgungsforschung e.V. (DNVF) entsprechend der Vorgaben für
DNVF-Memoranden erarbeitet.
Energiedichte von Lebensmitteln als Ernährungsstrategie bei
der Gewichtsregulation
Authors: Mack Isabelle 
Published: October 2022

ZusammenfassungFür die Energieaufnahme sind die Portionsgrößen und die
Energiedichte der Nahrung (kcal/g Lebensmittel) entscheidende Faktoren.
Die Reduktion der Energiedichte von Nahrung erlaubt dem Individuum in
ausreichend sättigender Menge zu essen, während gleichzeitig
weniger Energie zugeführt wird. Dies zeigen eine Vielzahl an
randomisierten kontrollierten Studien sowohl im Kindes- und Jugendbereich als
auch im Erwachsenenbereich und unter Einsatz unterschiedlicher Studiendesigns.
Gleichzeitig sind die Strategien zur Reduktion der Energiedichte
vielfältig und können auf verschiedene Ernährungsmuster,
Nahrungsmittelvorlieben und kulturelle Besonderheiten angepasst werden. Der
Artikel gibt einen Überblick über die Effekte des
Energiedichteprinzips auf i) die Energie- und Nahrungsaufnahme unter
Berücksichtigung des Gewichtsstatus, ii) Sättigung und
zugrundeliegende Mechanismen, bevor dann auf die Praxis näher
eingegangen wird. Dazu gehören die Einteilung der Lebensmittel nach den
Ampelfarben entsprechend ihrem Energiedichtegehalt, die Erläuterung des
wissenschaftlichen Hintergrundes zur Modulierung der Energiedichte sowie
Anwendungsbeispiele des Energiedichte-Prinzips. Insgesamt betrachtet handelt es
sich bei dem Energiedichteprinzip um ein sehr flexibles und unkompliziert
einsetzbares Instrument für die Ernährungsberatung und
-therapie, das von Patient*innen einfach zu verstehen ist.
Congenital anomalies and spontaneous abortion in mice resulting from the use of escitalopram
Authors: Sestario Camila Salvador , de Fátima Mestre Viviane , Nantes Martins Caio Cezar , Campos Zeffa Aline , Frítola Márjori , Sparça Salles Maria José 
Published: October 2022

Context Escitalopram (ESC) use during pregnancy has not been associated with teratogenic effects in fetuses. Aims To investigate whether ESC administered during pregnancy in mice induces maternal toxicity and teratogenicity in offspring. Methods Treated mice groups G1 and control G0 (n = 15 per group). Administration of ESC (G1) and saline solution (G0) during pregnancy and euthanasia on the 18th day. Pregnant female mice were treated with ESC (20 mg/kg, via gavage) or saline solution (control group) from the 5th to the 17th day of gestation, when implantation was consolidated. During intraembryonic development until the day before delivery, the drug had an influence on the development of alterations from its maintenance in the uterine environment and its development to the disturbance causing skeletal or visceral malformations. Key results The intrauterine development parameters that were altered by ESC treatment were: number of resorptions (G0: [0.93 ± 0.24]); G1: [3.33 ± 0.51]), post-implantation loss (G0: [3.95 ± 1.34], G1: [13.75 ± 3.62]) and reduced fetal viability: [97.30 ± 1.00]; G1: [81.09 ± 6.22]). Regarding fetal formation, the treated group had visceral malformations with a significant frequency: cleft palate (G0: [1.0%], G1: [11.86%]) and reduced kidneys (G0: [0%]; G1: [10.17%]). Regarding skeletal malformations, a higher frequency was observed in the following parameters: incomplete supraoccipital ossification (G0: [0%], G1: [15.25]), absence of ribs (G0: [0%], G1 (G0: [0%], G1 [15.25%]) and absence of one or more of the foot phalanges (G0: [1.0%]; 64%]). Conclusion Results indicate that ESC is an embryotoxic and teratogenic drug. Implications Until further studies are performed, greater caution is necessary in prescribing the drug to pregnant women.
Reading patterns, reformulation and eye-voice span (IVS) in sight translation
Authors: Chmiel Agnieszka , Lijewska Agnieszka 
Published: October 2022

Abstract
The study examined how a required reformulation of a source text affects reading patterns in sight translation. We also tested how interpreters regulated their eye-voice span (IVS, understood as the delay between viewing the source language word and speaking it in the target language) in the task. Twenty-four professional conference interpreters sight translated (from Polish into English) a text with syntactically symmetrical sentences (that could be copied in the target language) or asymmetrical ones (that required reformulation). The participants’ output and eye movements were recorded. Mean IVS turned out to exceed 8s. Text viewing durations and IVS did not differ between symmetrical and asymmetrical sentences. In contrast, reformulated output structures generated larger IVS than the retained ones. Also, words appearing later in the text on the screen were associated with longer IVS. This shows that IVS is a complex construct and that reformulation affects reading patterns in sight translation.
Non-zero constraints in elliptic PDE with random boundary values and applications to hybrid inverse problems
Authors: Alberti Giovanni S 
Published: October 2022

Abstract
Hybrid inverse problems are based on the interplay of two types of waves, in order to allow for imaging with both high resolution and high contrast. The inversion procedure often consists of two steps: first, internal measurements involving the unknown parameters and some related quantities are obtained, and, second, the unknown parameters have to be reconstructed from the internal data. The reconstruction in the second step requires the solutions of certain PDE to satisfy some non-zero constraints, such as the absence of nodal or critical points, or a non-vanishing Jacobian.
In this work, we consider a second-order elliptic PDE and show that it is possible to satisfy these constraints with overwhelming probability by choosing the boundary values randomly, following a sub-Gaussian distribution. The proof is based on a new quantitative estimate for the Runge approximation, a result of independent interest.
An inertial bipedal piezoelectric actuator with integration of triple actuation modes
Authors: Deng Jie , Wang Weiyi , Zhang Shijing , Lu Fei , Liu Yingxiang 
Published: October 2022

Abstract
Piezoelectric actuators based on inertial principle have been widely studied and applied in ultraprecision fields due to their simple structures. In this work, we proposed a bipedal piezoelectric actuator, which could work in synchronous inertial actuation mode (SIAM), bipedal alternating inertial actuation mode (BAIAM) and inertial impact actuation mode (IIAM). The step size, motion speed and carrying load are measured, and the rollback ratios are calculated to evaluate the displacement linearity. The experimental results confirm that SAIM has a simple exciting strategy, BAIAM has a smooth motion and IIAM has better load characteristics. The rollback ratio working in BAIAM is 0.7% and that is 14.4%, 69% in SIAM and IIAM, respectively, which proves that BAIAM effectively improves the displacement linearity. When working in IIAM, the load mass varying from 100 g to 350 g, the speed does not change significantly (the maximum variation range is 4% compared with 23% in SAIM and BAIAM under 0–500 g load). The developed actuator can switch between the triple actuation modes by changing the excitation signal to obtain compatible performance, it has potential in applications where large range, stable carrying load capacity and smooth motions are required, such as cell surgery and micromanipulation.
Engineering nonclassical SU(1,1) coherent states of light by multiphoton excitation
Authors: Javed Sunia , Bint Monir Hadiah , Amir Naila , Iqbal Shahid 
Published: October 2022

Abstract
Quantum optical systems with nonclassical features play a vital role in the physical implementation of a large variety of quantum technologies, such as quantum metrology, quantum information processing, and quantum computation protocols, and hence are important to exploit the quantum advantage. In this work, we construct a general class of nonclassical coherent states (CSs) of light and present a scheme to enhance their nonclassicality by multiphoton excitation. In particular, using various optical realizations of

s
u
(
1
,
1
)

Lie algebra, we construct CSs of light following Barut-Girardello formalism and then perform the multiphoton discrete excitation on these continuous-variable optical CSs. We investigate the nonclassical features by analyzing the photon-counting probability distribution, Mandel

Q
−

parameter, quadrature squeezing, and Wigner quasi-probability distribution. Our numerical results show that, for a particular set of parametric values, these multiphoton excited states exhibit sub-Poisson photon-counting statistics, quadrature squeezing, and negativity of Wigner distribution, which are indicators of nonclassicality. Moreover, it is shown that the nonclassical nature of these states gets enhanced as the photon-excitation number increases.
Synthesis of Zeolite as a Textile Dye Waste Adsorbent from Rice Husk Ash Using Microwave Heating Method
Authors: Karisma Achmad Dwitama , Altway Saidah , Agustiani Elly , Ningrum Eva Oktavia , Zuchrillah Daril Ridho 
Published: October 2022

Abstract
The zeolite was synthesized from rice husk ash with high silica content using the microwave heating method. In the pre-treatment step, the silica content of rice husk ash was extracted by HCl at various concentrations. Zeolite was synthesized by the reaction of rice husk ash, the aqueous solution of NaOH and Al2O3 in the flask reactor, and was treated by microwave heating at various power from 100-200 W. The crystalline phase and the characteristic structure of the product were analyzed by XRD and SEM analysis. Moreover, the surface area of the product was analyzed by BET analysis. The result shows that with 2 M HCl as an acid treatment in the pre-treatment step, the high surface area of the zeolite was obtained, i.e., 266.7 m2/g. The adsorption efficiency of the product was analyzed using methylene blue, methyl orange, and methyl red as the textile dye waste. The result shows that the adsorption efficiency of the product on the methylene blue, methyl orange, and methyl red was 94.2%, 93.89%, and 94.7%, respectively.
Analysis of Silica Activity Index from Geothermal Silica Scaling
Authors: Mulyana Cukup , Mahmudah  , Faizal Ferry 
Published: October 2022

AbstractSilica scaling causes problems in geothermal powerplants piping system such as clogging and reduction of pipe diameter. A suspended bulk sample was taken from Dieng powerplant Indonesia, with more than 80 % silica content. Before further utilization, the properties of the silica powder should be well understood to ensure for an example the correct usage of the application or another example choosing the efficent procedure in clogging prevention. The measure of the activity of silica powder can be expressed in the term of silica activity index (SAI). This index is the level of strength for the silica reactivity, it also indicated the increasing amount of amorphous phase relative to the amount of the crystal phase of silica. This study aims to determine SAI in variation with temperature of silica sample taken from suspended powder from geothermal brine. Experimental treatment on SAI determination consists of samples without preheating and with preheating at 400 °C, 500 °C, 650 °C, and 900 °C. The index was then calculated from the ratio of dissolved silica in the solution of 1 and 2 M 100 ml NaOH for 10 minutes. The experimental results show that the maximum value of SAI is 79% in the sample without heating at dissolving temperature 99 °C. The minimum value of SAI was 8% in samples with 900 °C preheated, treated with the same solution at dissolving temperature 80 °C. The XRD characterization result indicated that the sample without heating has an amorphous structure and tends to crystalize versus increasing heating temperature. At 900°C heating, the sample has a cristobalite and tridymite structure. The XRF analysis in the soluble fractions showed that the silica content in samples without heating is 0.52 wt% and the concentration also decreasing versus increasing temperature to 0.05 wt% for samples with 900°C heating. Hence, the silica activity index is influenced by sample crystallization during treatment with a strong base and heated dissolution.
Primary study of synthesis and dispersion of zirconia and silica nanoparticles for post-endodontic composite
Authors: Widodo Puji , Mulyawan Wawan , Djustiana Nina 
Published: October 2022

AbstractZirconia and silica-based composite are introduced as an alternative to post-core systems due to their high elastic modulus. The cast metal post-core systems in the application of dental material can cause stress concentration within the surrounding radicular dentin, resulting in root fractures. These materials provide more esthetical appealing and biocompatible restorations. However, the use of zirconia and silica nanoparticles as fillers tends to agglomerate in an organic solvent. The objective of the present report is to synthesize zirconia and silica nanoparticles by solgel method and subsequently, disperse them in an organic solvent by beads milling methods. The particle size distribution and stability were observed correspondingly using the particles size analyzer (PSA) and zeta potential. The initial average sizes of silica and zirconia particles in organic media were correspondingly 2.7 mm and 191 nm, respectively. After beads milling for 5 hours, silica and zirconia nanoparticles successfully were dispersed with average particles size of 91.5 nm and 124 nm, respectively. The zeta potentials of silica and zirconia suspensions were - 21.1 and -10.6 mV, respectively. The SEM image for both particles showed spherical morphology with agglomerated particles having primary particle sizes below 100 nm. Therefore, it was concluded that both particles can be applied as filler for a post-endodontic composite with an additional surfactant before polymerization.
The performance study of developed cost-effective Compton Camera based on Ce:GAGG scintillator using experimental measurements and CCMod of GATE simulation module
Authors: Zarei Hajar , Nagao Yuto , Yamamoto Kohei , Itoh Masatoshi , Yamaguchi Mitsutaka , Kawachi Naoki , Watabe Hiroshi 
Published: October 2022

Abstract
In our previous work, a cost-effective Compton camera (CC)
using Ce doped Gd3(Al,Ga)5O12(Ce:GAGG) scintillator
consisting of two detectors, scatterer
(20.8 × 20.8 × 5 mm3) and absorber
(41.7 × 41.7 × 10 mm3), was developed to image
gamma rays having energy more than 511 keV. This study fabricated
a newly developed CC with a larger scatterer and thinner
absorber. The system consists of two detectors: a scatterer and an
absorber of Ce:GAGG scintillator. The size of the scatterer and
absorber is the same; a
40-mm × 40-mm × 5-mm array block consists
of 40 × 40 pixels. The size of each scintillator pixel is
0.85 mm × 0.85 mm for both systems. Imaging
experiments of Na-22 and Cs-137 point sources were performed to
investigate the imaging capability of the new camera, and then the
obtained data were compared to the previous CC. The current CC's
absolute detection efficiency (DE
a
) and photopeak detection
efficiency (DE
p
) are improved by 1.6 and 2 times greater than
the previous one. At the same time, both systems' spatial and
angular resolutions are almost the same value at 511 keV. The
Compton camera module (CCMod) in GATE v9.0 was employed for Monte
Carlo simulations to reproduce the experimental data showing a good agreement.
Phycological exploration of the global biodiversity hotspots of Northeast India: discovery of a new species of soil-dwelling cyanobacteria, Desikacharya kailashaharensis sp. nov
Authors: Pal Sagarika , Saraf Aniket , Kumar Naresh , Singh Prashant 
Published: October 2022

Abstract
A soil-dwelling cyanobacterial strain (KLS-BP-3A_PS), has been isolated from the biodiversity rich Northeast region of India and characterized using a polyphasic approach. The strain was collected from a field covered with grass, near a stream from the Unakoti district of Tripura. Upon culturing in the laboratory, initial studies indicated the strain to be showing typical Nostoc or Nostoc-like morphology. Subsequently, 16S rRNA gene phylogenetic analyses using Neighbour joining, Maximum-likelihood, and Bayesian inference methods gave a distinct and stable positioning of the strain inside the genus Desikacharya. Upon recovery of the full-length operon of the 16S–23S ITS region with both tRNAs (tRNAIle and tRNAAla), the folded secondary structures revealed unique patterns of the D1-D1’, V2, Box-B, and V3 regions of the strain KLS-BP-3A_PS as compared to phylogenetically related species of the genus Desikacharya. The total evidence approach indicated conclusively that the strain under investigation is a new species of the genus Desikacharya, which we describe as Desikacharya kailashaharensis in accordance with the International Code of Nomenclature for algae, fungi, and plants. Further, 16S rRNA gene phylogeny and evaluation of the 16S–23S ITS operons along with implying a re-examination of the family level affiliation of Desikacharya as well its generic limits may be in order. Notably, this study brings into focus the very less explored Northeast region of India which shares two global biodiversity hotspots in the world.
Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function
Authors: Heppert Jennifer K , Lickwar Colin R , Tillman Matthew C , Davis Briana R , Davison James M , Lu Hsiu-Yi , Chen Wei , Busch-Nentwich Elisabeth M , Corcoran David L , Rawls John F 
Published: October 2022

Abstract
Transcription factors play important roles in the development of the intestinal epithelium and its ability to respond to endocrine, nutritional, and microbial signals. Hepatocyte nuclear factor 4 family nuclear receptors are liganded transcription factors that are critical for the development and function of multiple digestive organs in vertebrates, including the intestinal epithelium. Zebrafish have 3 hepatocyte nuclear factor 4 homologs, of which, hnf4a was previously shown to mediate intestinal responses to microbiota in zebrafish larvae. To discern the functions of other hepatocyte nuclear factor 4 family members in zebrafish development and intestinal function, we created and characterized mutations in hnf4g and hnf4b. We addressed the possibility of genetic redundancy amongst these factors by creating double and triple mutants which showed different rates of survival, including apparent early lethality in hnf4a; hnf4b double mutants and triple mutants. RNA sequencing performed on digestive tracts from single and double mutant larvae revealed extensive changes in intestinal gene expression in hnf4a mutants that were amplified in hnf4a; hnf4g mutants, but limited in hnf4g mutants. Changes in hnf4a and hnf4a; hnf4g mutants were reminiscent of those seen in mice including decreased expression of genes involved in intestinal function and increased expression of cell proliferation genes, and were validated using transgenic reporters and EdU labeling in the intestinal epithelium. Gnotobiotics combined with RNA sequencing also showed hnf4g has subtler roles than hnf4a in host responses to microbiota. Overall, phenotypic changes in hnf4a single mutants were strongly enhanced in hnf4a; hnf4g double mutants, suggesting a conserved partial genetic redundancy between hnf4a and hnf4g in the vertebrate intestine.
Gattaca as a lens on contemporary genetics: marking 25 years into the film’s “not-too-distant” future
Authors: Ogbunugafor C Brandon , Edge Michael D 
Published: October 2022

Abstract
The 1997 film Gattaca has emerged as a canonical pop culture reference used to discuss modern controversies in genetics and bioethics. It appeared in theaters a few years prior to the announcement of the “completion” of the human genome (2000), as the science of human genetics was developing a renewed sense of its social implications. The story is set in a near-future world in which parents can, with technological assistance, influence the genetic composition of their offspring on the basis of predicted life outcomes. The current moment—25 years after the film’s release—offers an opportunity to reflect on where society currently stands with respect to the ideas explored in Gattaca. Here, we review and discuss several active areas of genetic research—genetic prediction, embryo selection, forensic genetics, and others—that interface directly with scenes and concepts in the film. On its silver anniversary, we argue that Gattaca remains an important reflection of society’s expectations and fears with respect to the ways that genetic science has manifested in the real world. In accompanying supplemental material, we offer some thought questions to guide group discussions inside and outside of the classroom.