bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yonder: A Python Package for Data Denoising and Reconstruction
Authors: Chen 彭 Peng 琛 , S. de Souza Rafael 
Published: March 2022

Abstract
We present a standalone implementation of a data-deconvolution method based on singular value decomposition. The tool is written in python and packaged in the open-source yonder package. yonder receives as input two matrices, one for the data and another for the errors, and outputs a denoised version of the original dataset. In this Research Note, we briefly describe the methodology and show a demonstration of the yonder on a simulated dataset.
Les conséquences distributives des politiques climatiques : retour sur 30 ans de (non-)débat en Allemagne
Authors: Pottier Antonin 
Published: March 2022

L’article étudie trois politiques environnementales débattues en Allemagne dans les trente dernières années et qui s’inscrivent dans une perspective de tarification du carbone : la réforme écologique des impôts (ökologische Steuerreform) dans les années 1990, la contribution climatique (Klimaschutzbeitrag) en 2015, le prix du CO 2 (CO 2 Preis) en 2019. Il s’intéresse en particulier aux conséquences distributives de ces politiques, et à quel point les acteurs, dans leurs discours et dans leurs choix, y ont été attentifs. Il montre que leurs conséquences différenciées, et potentiellement injustes, sur les différentes catégories de ménages ne sont jamais devenues un point central du débat public, contrairement aux conséquences sur la compétitivité de l’industrie allemande.
La politique allemande de l’aide climatique
Authors: Ledger Ellen , Klöck Carola 
Published: March 2022

Le financement climatique – le soutien financier des pays développés aux pays en développement pour l’atténuation et l’adaptation au changement climatique – représente un pilier clé des négociations climatiques et de la justice climatique internationale. Alors que les accords climatiques contiennent des promesses de financement climatique, la mise en application de ces promesses ainsi que la contribution réelle des pratiques de soutien à la justice climatique, sont souvent remises en question. Nous examinons ici l’aide climatique de l’Allemagne, un des principaux acteurs du financement climatique, par le prisme de la justice climatique. Grâce aux données de l’Organisation de Coopération et de Développement Économiques (OCDE), nous analysons l’aide allemande au développement pour la période 2009-2019, en nous intéressant surtout à trois éléments de la justice climatique : l’importance accordée à l’adaptation, la prise en compte de la vulnérabilité climatique, et la question de l’additionnalité. Notre analyse montre que certains aspects de la justice climatique semblent être pris en compte par l’Allemagne dans sa politique de coopération climatique mais qu’il reste des points à améliorer pour rendre son soutien climatique aux pays du Sud plus juste, notamment en renforçant son action sur les Pays les Moins Avancés (PMA) et les Petits États Insulaires en voie de Développement (PEID), et en développant davantage ses programmes de subventions.
Sciences interdisciplinaires et politique du climat
Authors: Niewöhner Jörg , Delau-Wendt Maïté , Windels Loïc 
Published: March 2022

Dans cet article, je m’intéresse à la relation qu’une recherche interdisciplinaire sur les conséquences du changement climatique (ou « impacts climatiques ») entretient avec la politique du climat, en particulier en Allemagne. J’esquisserai d’abord le style de pensée dominant dans ce champ de recherche et montrerai comment l’accent mis sur la modélisation rend invisibles certaines différences (sociales) significatives. Sur cette base, et en prenant l’exemple allemand des comités d’experts, j’examinerai la manière dont l’action politique en contexte d’incertitude fait naître entre la science et la politique une relation qui conduit à un rétrécissement – toujours aussi d’ordre disciplinaire – de la pratique scientifique et à une dépolitisation du discours politique. J’opposerai à cette évolution une recherche sur les impacts climatiques qui soit publique, assume sa dimension politique, et s’engage avec tous ses modèles dans un processus de problématisation, dont l’objectif est la recherche d’un nouvel ordre moral qui respecte les limites planétaires.
Scientists for Future et la consultation scientifique dans le champ politique
Authors: Hagedorn Gregor , von Elverfeldt Kirsten , Windels Loïc 
Published: March 2022

À l’heure de la crise du climat et de la biodiversité, les relations entre la science, la société et la politique font à nouveau l’objet d’intenses débats. En s’appuyant sur l’exemple du mouvement « Scientists for Future » (S4F), qui a vu le jour en 2019 en Allemagne, en Autriche et en Suisse, cet article met en lumière les options dont disposent les scientifiques pour contribuer, avec de nombreux autres acteurs, à une société durable. Plus précisément, nous réfléchissons aux problèmes et aux opportunités d’une communication scientifique personnelle axée sur le dialogue et menée par des scientifiques engagés sur le plan social et politique. Nous argumentons que la consultation dans le champ politique et la communication scientifique ont besoin, pour parvenir à des connaissances susceptibles de changer le cours des choses, de l’engagement personnel des scientifiques. Dans un dialogue respectueux, les scientifiques, les citoyen·ne·s et les décideur·euse·s peuvent développer ensemble des recommandations d’action qui mènent à des solutions politiques. Les scientifiques ne peuvent pas se tenir à l’écart des enjeux politiques sur les questions existentielles de la société : qu’ils se taisent ou qu’ils parlent, les deux sont politiques. Mais il est essentiel que dans cette activité politique de conseil, leur engagement au nom de certaines valeurs et leur expertise scientifique fassent l’objet d’une communication responsable, transparente et réfléchie.
Combinatorial Expression of NK Cell Receptors Governs Cell Subset Reactivity and Effector Functions but Not Tumor Specificity
Authors: Rocca Yamila , Pouxvielh Kevin , Marotel Marie , Benezech Sarah , Jaeger Baptiste , Allatif Omran , Bendriss-Vermare Nathalie , Marçais Antoine , Walzer Thierry 
Published: March 2022

Abstract
NK cell receptors allow NK cells to recognize targets such as tumor cells. Many of them are expressed on a subset of NK cells, independently of each other, which creates a vast diversity of receptor combinations. Whether these combinations influence NK cell antitumor responses is not well understood. We addressed this question in the C57BL/6 mouse model and analyzed the individual effector response of 444 mouse NK cell subsets, defined by combinations of 12 receptors, against tumor cell lines originating from different tissues and mouse strains. We found a wide range of reactivity among NK subsets, but the same hierarchy of responses was observed for the different tumor types, showing that the repertoire of NK cell receptors does not encode for different tumor specificities but for different intrinsic reactivities. The coexpression of CD27, NKG2A, and DNAM-1 identified subsets with relative cytotoxic specialization, whereas reciprocally, CD11b and KLRG1 defined the best IFN-γ producers. The expression of educating receptors Ly49C, Ly49I, and NKG2A was also strongly correlated with IFN-γ production, but this effect was suppressed by unengaged receptors Ly49A, Ly49F, and Ly49G2. Finally, IL-15 coordinated NK cell effector functions, but education and unbound inhibitory receptors retained some influence on their response. Collectively, these data refine our understanding of the mechanisms governing NK cell reactivity, which could help design new NK cell therapy protocols.
PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation
Authors: Lewis Brandon W , Amici Stephanie A , Kim Hye-Young , Shalosky Emily M , Khan Aiman Q , Walum Joshua , Gowdy Kymberly M , Englert Joshua A , Porter Ned A , Grayson Mitchell H , Britt Rodney D , Guerau-de-Arellano Mireia 
Published: March 2022

Abstract
Severe asthma is characterized by steroid insensitivity and poor symptom control and is responsible for most asthma-related hospital costs. Therapeutic options remain limited, in part due to limited understanding of mechanisms driving severe asthma. Increased arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is increased in human asthmatic lungs. In this study, we show that PRMT5 drives allergic airway inflammation in a mouse model reproducing multiple aspects of human severe asthma. We find that PRMT5 is required in CD4+ T cells for chronic steroid-insensitive severe lung inflammation, with selective T cell deletion of PRMT5 robustly suppressing eosinophilic and neutrophilic lung inflammation, pathology, airway remodeling, and hyperresponsiveness. Mechanistically, we observed high pulmonary sterol metabolic activity, retinoic acid-related orphan receptor γt (RORγt), and Th17 responses, with PRMT5-dependent increases in RORγt’s agonist desmosterol. Our work demonstrates that T cell PRMT5 drives severe allergic lung inflammation and has potential implications for the pathogenesis and therapeutic targeting of severe asthma.
Intracranial Arachnoid Cysts Presenting with First-Episode Mania and Subsequent Hyperammonemic Encephalopathy: A Case Report
Authors: Kantipudi Suvarna Jyothi , Suresh Navina 
Published: March 2022

Abstract
Intracranial arachnoid cysts are often an incidental discovery in the course of neuroimaging for other conditions. While often asymptomatic, cysts which enlarge can cause mass or pressure effects on adjacent structures. We report a 33-year-old male patient who presented with first episode of manic symptoms. Following treatment with sodium valproate patient developed altered sensorium and was subsequently diagnosed with middle cranial fossa arachnoid cysts and valproic acid-induced hyperammonemic encephalopathy that was successfully treated with enteric lactulose. There are several case reports of arachnoid cysts presenting in patients with psychiatric disorders and debating whether these cysts are a cause or co-occurrence. In 16 reported patients, who had arachnoid cysts with psychiatric symptoms, 9 had cysts exerting mass/pressure effects. Three patients had surgical intervention and showed significant improvement following surgery. So did 1 patient who was treated with mannitol infusion. Intracranial arachnoid cysts may also present with atypical psychiatric symptoms or complicate the treatment process by way of poor response or treatment emergent adverse effects. There is an important role for thorough neurological examination, neuroimaging, and vigilant use of psychotropics in such patients.
A Case of Steroid Induced Psychosis
Authors: Batra Surbhi , Narvariya Ashish , Kandpal Manish 
Published: March 2022

Abstract
Corticosteroids are one of the widely used drugs in medicine; however, the use of steroids is associated with undesirable side effects. We present here a case of 18-year-old girl with nephrotic syndrome who developed auditory hallucinations, muttering to self, social withdrawal, and fearfulness after she was given steroids for her treatment. Steroids were tapered and stopped, and she was started on olanzapine after which she improved completely. Although a relationship between hypothalmic–pitutary axis and psychosis has been clearly established, still there is a dearth of literature in the area of steroid-induced psychosis and its management.
Anxiety, Knowledge, Attitude, and Preventive Practices Toward COVID-19 Among Patients with Psychiatric Illness – A Comparative Study from South India
Authors: Raghuraman Preethy , Simiyon Manjula , Rudravaram Vishnu Vardhan , Mani Manikandan , Thilakan Pradeep 
Published: March 2022

Background:
Coronavirus disease 2019 (COVID-19) pandemic has induced serious threats to people's mental health. There are increasing concerns about anxiety linked with COVID-19. There are very few studies conducted to understand the needs of the mentally ill during this pandemic.

Aim:
The study aimed to assess and compare the anxiety, knowledge, attitude, and preventive practices related to COVID-19 among people with and without psychiatric illnesses.

Materials and Methods:
A cross-sectional analytical study was conducted among patients with psychiatric illnesses and their caregivers in the psychiatry department of a tertiary hospital. All consenting adults with a diagnosed psychiatric illness and scoring < 3 in the Clinical Global Impression-Severity scale were included in the case group. All consenting adult caregivers who accompany the patients were included in the reference group. Coronavirus Anxiety Scale and Knowledge, Attitude, and Preventive Practices towards COVID-19 Questionnaire were administered. Data were analyzed using IBM SPSS (19.0 version).

Results:
Less than 10% of the participants in both the groups had COVID-related anxiety. 98.3% of the participants in both the groups knew that isolation and treatment of COVID-19-affected individuals can prevent the spread of the virus. Avoidance of handshaking (case – 85% and reference – 81.7%) and going out of home unnecessarily (case – 83.3% and reference – 81.7%) were the predominant preventive practices in both the groups. Only, the attitude had a statistically significant difference between both the groups (P < 0.05).

Conclusion:
Patients with psychiatric illness had fair knowledge, and they followed preventive practices toward COVID-19 that are comparable with healthy individuals. There were discrepancies between their knowledge and preventive practices.
Psychological Impact of COVID-19 on Female Health Professionals
Authors: Bansal Priya , Agarwal Supriya 
Published: March 2022

Background:
The World Health Organization in January 2020 declared an outbreak of novel coronavirus disease, COVID-19, an international public health emergency. The suddenness of this calamity with no end in sight caused a great deal of stress, anxiety, and depression throughout the world.

Aim:
The aim of this study was to assess the psychological impact during the developing COVID-19 situation among female health professionals.

Methods:
This was an observation-based cross-sectional study conducted for a total of 3-month duration between August and October 2020. A structured questionnaire to assess the psychological impact was sent via the (email) electronic mail system, and responses were obtained from 343 female doctors.

Results:
The mean ± standard deviation values for age were found to be 39 ± 8 years. Insomnia, stress, and anxiety were seen in a majority of the respondents.

Conclusions:
The present study has shown severe psychological impact associated with the pandemic on female health-care workers and highlights the major factors associated.
Impact of Covid-19 pandemic on quality of life in persons with alcohol use disorder - A cross-sectional study
Authors: Ponnusamy Sindhu , Kantipudi Suvarna Jyothi 
Published: March 2022

Introduction:
Alcohol use disorder has a chronic relapsing course. Various biological, psychological, environmental, and psychosocial factors play a major role in maintaining abstinence and determining relapse in patients. The COVID-19 pandemic has caused significant changes in every person's life. It is important to assess how this situation has determined alcohol use in the patients who had utilized deaddiction services in the past.

Aim:
The aim of this study is to assess the pattern of alcohol use, perceived stress, and quality of life (QOL) during COVID-19 in patients who had utilized deaddiction services for alcohol use disorder in the preceding 1 year.

Materials and Methods:
A cross-sectional design was employed in the study. After obtaining consent, telephonic interviewing of patients who had utilized deaddiction services during January–December 2019 was done, and questionnaires including sociodemographic details, Severity of Alcohol Dependence Questionnaire, Brief Substance Craving Scale, Perceived Stress Scale-10, and WHOQOL-BREF scale were administered to assess the pattern of alcohol use, stress levels, and QOL. Comparisons were carried out on different variables using SPSS version 20.

Results:
A total of 122 patients were inducted into the study. About 70.5% of the relapsed individuals belonged to joint families. There was a significant association between the poor QOL and relapse status of the individuals. High levels of stress were reported among the individuals who have relapsed compared to nonrelapsed individuals.

Conclusion:
High rates of relapse and higher stress levels were found in our study. This study has helped us to understand the pattern of alcohol use in individuals during this pandemic. It is important to address the factors contributing to relapse in individuals so as to focus on developing and implementing feasible and accessible interventions to help the individuals.
Health related quality of life among rural elderly using WHOQOL-BREF in the most backward district of India
Authors: Singh Abhishek , Palaniyandi Subramani , Palaniyandi Anitha , Gupta Vikas 
Published: March 2022

Background:
In India, the population of above 60 years was approximately 8.2% in 2011, which is expected to rise to 11.6% by 2026. Due to epidemiological transition of diseases, morbidity of chronic nature will increase with increase of elderly population and it will affect the elderly quality of life (QOL). Aim: This study made an attempt to capture health-related quality of life HRQOL and its correlates among elderly subjects in most backward district of India.

Methods:
This cross-sectional study was conducted in Nagina for a duration of 4 months and included 430 elderly (60 years or above) dwelling in the same place for more than 1 year as participants. The information on sociodemographic details, WHOQOL-BREF scale details and history of chronic diseases or disorders was collected by multipurpose health workers female using a pretested, predesigned, standardized questionnaire. An association between variables and poor quality of life was significant if the P value was less than 0.05.

Results:
Nearly half of study participants were living in joint families (45.3%) and 67.7% of elderly gave history of chronic morbidity. There were nearly half of participants (48.8%) with poor QoL in physical health domain. Multiple linear regression analysis revealed that older age, male, no schooling, without spouse, lower economic status and chronic disorder were independently associated with low QOL score.

Conclusion:
The study reported that nearly half of the elderly (46.7%) had poor health QoL. The family physicians shall provide preventive and promotive measures to reduce the chronic morbidity among elderly to improve QOL.
Primary hepatic Hodgkin’s lymphoma: A case report
Authors: Nasiri Abdulrahman M. , Alshammari Manal , Ahmed Abdulrahman , Elsir Bader , Alghethber Hamad 
Published: March 2022

Introduction:
Hodgkin lymphoma (HL) is an uncommon hematological malignancy that primarily occurs in young adults and less frequently in elderly individuals. HL has characteristics cells derived from B lymphocytes (known Reed–Sternberg (HRS) cells). Primary hepatic Hodgkin disease is very rare presentation accounting for less than 0.4% of the cases. Due to its rare occurrence, the pathogenesis of PHL is still unclear, Clinical manifestations, laboratory findings, and imaging features are usually nonspecific, making it difficult to diagnose.

Patient Concerns:
69 years old Saudi Female, known case of Hypertension presented to our hospital with history of fever, jaundice, and poor appetite for about 2 weeks with significant weight loss.

Diagnosis:
Laboratory findings showed cholestatic pattern with total bilirubin 107.2 mg/dl, alkaline phosphatase 2076 IU/l, AST 153 IU/l and ALT 73 IU/l. Imaging with US revealed normal liver size with diffuse increase echogenicity, MRCP showed multiple stones within the gallbladder without evidence of obstruction or CBD dilatation and pan-computed tomography (CT) revealed mildly enlarged and fatty liver. CT-guided fine needle aspiration cytology (FNAC) and biopsy from the liver were consistent with primary hepatic Hodgkins lymphoma. Intervention: The patient received 5 cycles of ABVD.

Outcomes:
After the completion of the 5 cycles patient showed good response to the treatment with normalization of her liver function and regression in the size of liver on CT.

Conclusion:
PHL is a rare disease. The clinical presentation is variable and radiological features are not specific. Histology is mandatory for definitive diagnosis. The optimal therapy and outcomes for PHL is still unclear. ABVD is the most frequently used chemotherapy regimen. Multidisplinary approach including surgery and radiotherapy is another option.
Relationship of alcohol use pattern with locus of control and impulsivity: A cross-sectional study in hospitalized alcohol use disorder patients in Western India
Authors: Patel Nisheet , Sharma Himanshu , Mahida Ankur , Mistry Hansal 
Published: March 2022

Background:
Alcohol use disorders (AUDs) are increasing in developing countries like India and it has high relapse rates. Locus of control (LOC) and impulsivity can be important predictors of relapse and knowledge about them can help in management of AUD.

Method:
Cross-sectional analytical study of 116 indoor patients in tertiary care hospital, between ages 18 and 65 years diagnosed as AUD according to DSM-5, after acute detoxification was done. For interview, a sociodemographic sheet, Alcohol Use Disorder Identification Test, Drinking-Related Locus of Control Scale, and Barrett’s Impulsiveness Scale 11 scale (Gujarati versions) were used. Patients with complicated withdrawal and any other comorbid organic brain conditions were excluded. The data were analyzed using SPSS version 25.

Result:
Total participants consisted of 65% middle-aged (35–50 years) rural inhabitants. Eighty-six-percent of patients were employed and around 80% were educated >5th standard. No association was found between sociodemographic variables and severity of alcohol use. Severity of alcohol use increased with more duration of alcohol consumption (P = 0.001). Patients being earlier aged for first intake of alcohol had a high external LOC (r = 0.209, P = 0.050). Patients with high external LOC (P = 0.003) and more impulsivity (P = 0.001) had more relapses (more numbers of attempts to quit alcohol). With increased external LOC (r = 0.315) and increased impulsivity (r = 0.716), severity of alcohol use also increased. As impulsivity increased, patients’ LOC was found more toward external side (P = 0.007) (r = 0.345).

Conclusion:
External LOC and impulsivity have a strong association with alcohol use. Patients with high external LOC and more impulsivity had early age of first intake, severe alcohol use, and more duration of alcohol consumption.