bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping hydrogen storage capacities of UK offshore hydrocarbon fields and exploring potential synergies with offshore wind
Authors: Peecock Anna , Edlmann Katriona , Mouli-Castillo Julien , Martinez-Felipe Alfonso , McKenna Russell 
Published: August 2022

Abstract
Energy storage is an essential component of the transitioning UK energy system, a crucial mechanism for stabilizing intermittent renewable electricity supply and meeting seasonal variation in demand. Low-carbon hydrogen provides a balancing mechanism for variable renewable energy supply and demand, and a method for decarbonizing domestic heating, essential for meeting the UK's 2050 net-zero targets. Geological hydrogen storage in porous rocks offers large-scale energy storage over a variety of timescales and has promising prospects due to the widespread availability of UK offshore hydrocarbon fields, with established reservoirs and existing infrastructure. This contribution explores the potential for storage within fields in the UK Continental Shelf. Through comparison of available energy storage capacity and current domestic gas demands, we quantify the hydrogen required to decarbonize the UK gas network. We estimate a total hydrogen storage capacity of 3454 TWh, significantly exceeding the 120 TWh seasonal domestic demand. Multi-criteria decision analysis, in consultation with an expert focus group, identified optimal fields for coupling with offshore wind, which could facilitate large-scale renewable hydrogen production and storage. These results will be used as inputs for future energy system modelling, optimizing potential synergies between offshore oil and gas and renewables sectors, in the context of the energy transition.
Trace metals in CO
2
-rich Green River springs, Utah, USA: an analogue for engineered storage
Authors: Wilkinson Mark , Carruthers Kit , Haszeldine R. Stuart 
Published: August 2022

Abstract

Sedimentary rocks with high natural CO
2
concentrations provide invaluable analogues for the long-term engineered storage of CO
2
. Some previous studies have reported high trace metal concentrations in sandstone aquifers exposed to CO
2
, a cause for concern should stored CO
2
leak into underground sources of drinking water. However, the intensively studied Jurassic sandstone aquifer in the San Rafael–Green River (Utah, USA) area has trace metal concentrations that are within US Environmental Protection Agency's limits for drinking water. Exceptions are As which is plausibly introduced into the aquifer by saline brines external to the aquifer, and salinity which largely is. This shows that CO
2
in aquifers does not inevitably cause trace metal contamination. CO
2
–water–rock batch experiments elucidated the controls on the trace metal concentrations. After the addition of CO
2
, the experiments reproduce Cu, Cd, Hg, Ni and Zn well, with less good agreement for Cr and Pb although these are still low compared to drinking water standards. Major cations used as fingerprints for mobilization mechanisms suggest that the trace metals are largely derived by desorption, possibly from grain-coating Fe-oxides, rather than by the dissolution of mineral phases. Possible exceptions are Pb and Ni, plus As which is derived from saline brines.
Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia
Authors: Roma Alessia , Tcheng Matthew , Ahmed Nawaz , Walker Sarah , Jayanth Preethi , Minden Mark D. , Hope Kristin , Nekkar Rao Praveen P. , Luc Jessica , Doxey Andrew C. , Reisz Julie A. , Culp-Hill Rachel , D'Alessandro Angelo , Spagnuolo Paul A. 
Published: August 2022

Abstract

Acute myeloid leukemia (AML) is a hematologic malignancy metabolically dependent on oxidative phosphorylation and mitochondrial electron transport chain (ETC) activity. AML cells are distinct from their normal hematopoietic counterparts by this metabolic reprogramming, which presents targets for new selective therapies. Here, metabolic changes in AML cells after ETC impairment are investigated. Genetic knockdown of the ETC complex II (CII) chaperone protein SDHAF1 (succinate dehydrogenase assembly factor 1) suppressed CII activity and delayed AML cell growth in vitro and in vivo. As a result, a novel small molecule that directly binds to the ubiquinone binding site of CII and inhibits its activity was identified. Pharmacologic inhibition of CII induced selective death of AML cells while sparing normal hematopoietic progenitors. Through stable isotope tracing, results show that genetic or pharmacologic inhibition of CII truncates the tricarboxylic acid cycle (TCA) and leads to anaplerotic glutamine metabolism to reestablish the truncated cycle. The inhibition of CII showed divergent fates, as AML cells lacked the metabolic plasticity to adequately utilize glutamine metabolism, resulting in preferential depletion of key TCA metabolites and death; normal cells were unaffected. These findings provide insight into the metabolic mechanisms that underlie AML's selective inhibition of CII.

Implications:
This work highlights the effects of direct CII inhibition in mediating selective AML cell death and provides insights into glutamine anaplerosis as a metabolic adaptation that can be therapeutically targeted.
Beyond the Survival of the Global Humanities
Authors: Guyer Sara 
Published: August 2022

Abstract
Over the past several years, scholars and critics have begun to talk about the survival of the humanities rather than its crisis. This essay traces the emergence of a rhetoric of salvation and survival in academic advocacy literature, evident in the genres, arguments, and metaphors that writers use to describe the academic humanities. Focusing, first, on a set of recent books that advocate for the humanities as a resource for deliberation, community formation, and critique, the essay then turns to the origin of the contemporary humanities in European philology as a background for the dualism of survival and crisis in narratives about the humanities. The essay concludes by arguing that we need a new framework for understanding the survival of the humanities as global humanities, in particular, one that does not emerge from a European and Christological sense of survival. Drawing upon research conducted as part of the “World Humanities Report,” the essay identifies some of these alternative frameworks based upon the humanities in China, South Africa, and Argentina.
The Positive Humanities: A Focus on Human Flourishing
Authors: Pawelski James O. 
Published: August 2022

Abstract
The Positive Humanities can be defined as the branch of learning concerned with culture in its relation to human flourishing. This new field advocates for a eudaimonic turn in the humanities, an explicit recognition of and commitment to human flourishing as a central theme of study and practical aim of the humanities. It holds that this eudaimonic turn can reconnect the humanities with their initial values and goals and provide a unifying and inspiring rationale for the humanities today, opening pathways for greater individual and collective flourishing in societies around the world. After exploring the historical roots and conceptual orientations of the Positive Humanities (which are inclusive of the arts), I present five recommendations for strengthening the focus of the humanities on human flourishing: emphasize 1) wisdom as much as knowledge, 2) collaboration as much as specialization, 3) the positive as much as the negative, 4) effective friction as much as increased efficiency, and 5) the flourishing of humans as much as the flourishing of the humanities.
The Unsettled History of Passive Voice in the Sciences: The Royal Society, 1665–2020
Authors: Plotnick Jerry 
Published: August 2022

Abstract
This paper seeks to understand the rise and fall of passive voice in the publications of the Royal Society from 1665 to 2020. Though it came to be seen as the very voice of scientific objectivity, passive voice remained in the clear ascendency for just over a century. The rise of passive voice coincided with the progressively diminished role of an observer who directly apprehends the world through the senses. The recent re-emergence of active voice is more of a puzzle. I argue that the unsettled history of voice reflects the unsettled relationship of science to agency and conscious experience.
The Impact of Intratympanic Steroid Dosage on Hearing Recovery in Sudden Sensorineural Hearing Loss
Authors: Nelson Lacey , Swanson Daniel , Borowiec Elizabeth , Crossley Jason , Geng Xue , Cao Xiao , Kim Hung Jeffrey , Hoa Michael 
Published: August 2022

Objective: To investigate how dexamethasone dosage impacts intratympanic steroid therapy (IST) for treatment of sudden sensorineural hearing loss (SSNHL). Study Design: Retrospective review. Methods: Inclusion criteria identified subjects who received IST between January 1, 2010 and June 1, 2020 for iSSNHL. Subjects with Meniere’s disease, autoimmune inner ear disease, subjects who received injections of non-dexamethasone steroid formulations, and subjects with missing audiogram data were excluded. Subjects were stratified by dexamethasone dosage: low-dose (10 mg/ml) versus high-dose (24 mg/ml), time-to-treatment and oral corticosteroid use. Outcome measures included post-treatment improvement in 4-frequency pure tone average (4F-PTA [500, 1000, 2000,4000 Hz]), low- and high-frequency PTA (250-1000 Hz and 2000-8000 Hz, respectively). Results: Of the 55 included subjects (50.9% male, mean age 48.9 ± 16.4 years), 31 received high-dose while 24 received low-dose injections. 90.9% of subjects were treated with oral steroids prior to or during IST. No significant differences in hearing outcomes were observed between low- and high-dose cohorts or when stratifying by oral steroid use. Time-to-treatment analysis comparing ≤1 month (67.3%) versus >1 month (32.7%) groups demonstrated a significant improvement in post-treatment 4F-PTA ( P = .01) in the ≤1 month group. Conclusions: Hearing recovery was not significantly different between the 10 mg/ml versus 24 mg/ml doses of intratympanic dexamethasone, suggesting that steroid dose may not impact the efficacy of IST. A shorter time-to-treatment was observed to be favorable for hearing improvement.
Farm-to-School programmes, benefits, health outcomes and barriers: A structured literature review
Authors: Mishra Sachin K , Khanal Aditya R , Collins William J 
Published: August 2022

Introduction: A common refrain in public health and medicine concerns the rapidly rising incidence of obesity and metabolic-like syndromes over the last two decades. A plethora of data suggests there are many roots to the issue and what to do about it. The rise of childhood obesity and the growing incidence of adult endocrine diseases like type 2 diabetes mellitus in paediatric populations are the most concerning. One of the solutions that aims to tackle health and food justice issues is the Farm-to-School programme (FTSP), which helps bring local fruit and vegetables (FVs) to schools and associated nutrition-related programmes. In the USA, a significant expansion of FTSPs has happened since the early 2000s. Numerous economic, social and nutritional benefits of these programmes have been documented, and various methodologies have been used to elucidate the benefits and barriers. Method: This paper reviews the multifaceted strengths of FTSPs including health, institutional and farm-related benefits. The paper also discusses federal- and state-level environment and the obstacles to FTSP implementation. Conclusion: FTSPs offer a comprehensive way to strengthen childhood nutrition education and stimulate local communities economically and socially. FTSPs increase the purchase of locally produced food items, resulting in higher incomes for small farmers. FTSPs have also increased community engagement and new opportunities for farming businesses. In sum, FTSPs can be considered a boon for local schools, producers, communities and better health outcomes for school-age children. Teaching children about food literacy could prove beneficial for supporting their self-efficacy regarding foods and encouraging lifetime healthy dietary behaviours.
Biomechanical Comparison of Fiber Tape Device Versus Transarticular Screws for Ligamentous Lisfranc Injury in a Cadaveric Model
Authors: Koroneos Zachary A. , Manto Kristen M. , Martinazzi Brandon J. , Stauch Chris , Bifano Shawn M. , Kunselman Allen R. , Lewis Gregory S. , Aynardi Michael 
Published: August 2022

Background: The preferred method of fixation and surgical treatment for ligamentous Lisfranc injuries is controversial. Transarticular screws, bridge plating, fusion, and flexible fixation have been described, yet none have demonstrated superiority. Furthermore, screw fixation and plating often require secondary surgery to remove implants, leading surgeons to seek alternative fixation methods. Purpose: To compare transarticular screws and a fiber tape construct under a spectrum of biomechanical loads by evaluating the diastasis at 3 joints in the Lisfranc complex. Study Design: Controlled laboratory study. Methods: Eight matched pairs of fresh, previously frozen lower extremity cadaveric specimens were fixed with either 2 cannulated transarticular crossed screws or a fiber tape construct with a supplemental intercuneiform limb. The diastasis between bones was measured at 3 midfoot joints in the Lisfranc complex: the Lisfranc articulation, the second tarsometatarsal joint, and the intercuneiform joint. Measurements were obtained for the preinjured, injured, and fixation conditions under static loading at 50% donor body weight. Specimens then underwent cyclic loading performed at 1 Hz and 100 cycles, based on 100-N stepwise increases in ground-reaction force from 100 to 2000 N, to simulate postoperative loading from the partial weightbearing stage to high-energy activities. Failure of fixation was defined as diastasis ≥2 mm at the Lisfranc articulation (second metatarsal–medial cuneiform joint). Results: There were no significant differences in diastasis detected at the Lisfranc articulation or the intercuneiform joint throughout all loading cycles between groups. All specimens endured loading up to 50% body weight + 1400 N. Up to and including this stage, there were 2 failures in the cannulated transarticular crossed-screw group and none in the fiber tape group. Conclusion: The fiber tape construct with a supplemental intercuneiform limb, which does not require later removal, may provide comparable biomechanical stability to cannulated transarticular crossed screws, even at higher loads. Clinical Relevance: Ligamentous Lisfranc injuries are common among athletes. Therefore, biomechanical evaluations are necessary to determine stable constructs that can limit the time to return to play. This study compares the biomechanical stability of 2 methods of fixation for ligamentous injury through a wide spectrum of loading, including those experienced by athletes.
Efficacy of Repetitive Transcranial Magnetic Stimulation on Comorbid Anxiety and Depression Symptoms in Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Sham-Controlled Trials
Authors: Thatikonda Navya Spurthi , Vinod Pratibha , Balachander Srinivas , Bhaskarpillai Binukumar , Arumugham Shyam Sundar , Reddy Y.C. Janardhan 
Published: August 2022

ObjectiveTo systematically evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in reducing comorbid anxiety and depressive symptoms in patients with obsessive-compulsive disorder (OCD).MethodsThree electronic databases were searched for randomized, sham-controlled clinical trials evaluating rTMS for the treatment of OCD. Hedge's g was calculated as the effect size for anxiety/depression symptom severity (primary outcome) and OCD severity (secondary outcome). Subgroup analyses and meta-regression analyses were carried out to evaluate the most promising target and whether a reduction in OCD severity moderates the change in anxiety or depression scores.ResultsTwenty studies ( n = 688) were included in the meta-analysis. rTMS had small-medium effect size on OCD (Hedge's g = 0.43; 95% confidence interval [CI]: [0.20, 0.65]; P < 0.001), anxiety (Hedge's g = 0.3; 95% CI: [0.11, 0.48]; P = 0.001) and depression (Hedge's g = 0.24; 95% CI: [0.07, 0.40]; P = 0.003) symptoms. Subgroup analysis showed that protocols targeting dorsolateral prefrontal cortex (DLPFC) were effective for 3 outcome measures. The change in anxiety, but not depression severity, was moderated by a change in OCD symptom scores. However, the findings are uncertain as a majority of the studies had some concerns or a high risk of bias.ConclusionsActive rTMS protocol targeting DLPFC is effective in reducing the comorbid anxiety/depression symptoms along with OCD severity. The antidepressant effect is not moderated by the anti-obsessive effect of rTMS.
Hip offset and leg-length restoration in revision hip arthroplasty with a monoblock, hydroxyapatite-coated stem
Authors: Saunders Paul , Shaw Debbie , Sidharthan Sijin , Young Stephen K , Board Tim 
Published: August 2022

Aims: Restoration of normal hip biomechanics in arthroplasty surgery is important in order to achieve good muscle function and joint stability. Methods: In this retrospective cohort study, we examined the postoperative radiographs of 131 femoral revision arthroplasty procedures using a monoblock, fully hydroxyapatite (HA)-coated titanium stem. Femoral offset, modified-global offset and leg length were measured of the operated and contralateral hips. Results: Femoral offset was restored to ±10 mm in 108 cases (82%), modified-global offset was restored ±10 mm in 93 cases (71%) and leg length was restored to ±10 mm in 102 cases (81%). There were 4 dislocations with a mean follow-up period of 38 months. Conclusions: Restoration of hip biomechanics is achievable with a monoblock stem and thus is a viable option in revision hip arthroplasty.
Immunohistochemical Detection and Prognostic Significance of p53, Epidermal Growth Factor Receptor, Murine Double Minute 2, and Isocitrate Dehydrogenase 1 in Glioblastoma Multiforme Patients of Pakistan
Authors: Ali Syed Muhammad Adnan , Shamim Muhammad Shahzad , Enam Syed Ather , Ahmad Zubair , Adnan Yumna , Farooqui Hasnain Ahmed 
Published: August 2022

Introduction: Glioblastoma multiforme (GBM) is one of the deadliest cranial tumors occurring in adults. Various biomarkers have been tested for their significance in diagnosis, prognosis, and treatment of GBM. Some well-studied markers in GBM are Isocitrate dehydrogenase 1 (IDH1), Murine double minute 2 (MDM2), Epidermal Growth Factor Receptor (EGFR), and p53. The aim of this study was to investigate the protein expression of these markers in GBM patients of Pakistan. Methods: A total of 102 surgically resected formalin-fixed paraffin-embedded specimens from patients diagnosed and treated at Aga Khan University Hospital were included in this study. Immunohistochemistry (IHC) for IDH1, MDM2, EGFR, and p53 was performed using Dako EnVision System and respective monoclonal antibodies. Survival analysis was performed to check association of markers protein expression with prognosis in GBM patients. Results: There were 73 males and 29 females in this study, with a median age of 49 years at the time diagnosis. Overexpression of molecular markers was as follows: 52% for EGFR, 26% for p53, 72% for IDH1, and 83% for MDM2. We did observe that EGFR was significantly associated with increased age of our patients and with worse survival. Age > 40 years was a predictor for worse prognosis as well. Conclusion: EGFR overexpression and advanced age were worse prognostic indicators.
Improving detection and management of atrial fibrillation after ischaemic stroke in Glasgow (IMPROVE-AF): A quality improvement project
Authors: Johnston Fiona C , Cameron Alan C , Colquhoun Elizabeth , Murdoch David L , Dawson Jesse , Abdul-Rahim Azmil H 
Published: August 2022

Background: The use of cardiac monitoring to detect atrial fibrillation (AF) is routine after ischaemic stroke but is often delayed leaving patients at risk from undetected AF. We sought to improve the detection of AF by delivering early prolonged ‘in-house’ cardiac monitoring. Methods: We collected 3-months of data of people with stroke/transient ischaemic attack (TIA), but without AF, who underwent cardiac monitoring (Phase 1, pre-quality improvement project (QIP)). We then implemented an ‘in-house’ 7-day cardiac monitoring service for 12 months (Phase 2, during QIP). Results: We included 244 people in Phase 1 and 172 in Phase 2. In Phase 1, 232 (95%) people completed cardiac monitoring. Of these, new AF was detected in 10 (4%). Median time from stroke/TIA onset to availability of the monitoring report in Phase 1 was 50 (interquartile range (IQR): 24–123) days. In Phase 2, 166 (97%) of people completed 7-day cardiac monitoring, with new AF detected in 17 (10%). Median time from onset to availability of the report in Phase 2 was 12 (IQR: 9–15) days. In people with AF detected, ‘in-house’ monitoring reduced the time of stroke/TIA onset to anticoagulant commencement from 41 (Phase 1) to 14 (Phase 2) days. Discussion: The QIP has improved AF detection, reduced delays associated with conventional cardiac monitoring and prompted early initiation of oral anticoagulation.
Clinical characteristics in adult patients with somatic cough syndrome
Authors: Lai Kefang , Peng Wen , Zhan Wenzhi , Xie Jia-xing , Tian Jing , Zuo Xiao-ping , Long Li , Tang Jia-man , Pan Jia-yu , Jiang Mei , Zhong Nan-Shan 
Published: August 2022

Objective: The data in regard of the clinical characteristics and diagnosis of somatic cough syndrome in adults were limited. The aim of this study was to fill that gap. Methods: This was a retrospective analysis of patients with somatic cough syndrome. We described clinical characteristics of adult patients with somatic cough syndrome. Results: Twenty-three somatic cough syndrome patients were identified in 543 adult patients with chronic cough. Psychiatric disorder of these patients was identified as anxiety ( n = 8), obsessive-compulsive ( n = 7), somatoform ( n = 6), depression ( n = 3), and cognitive bias ( n = 1). Twelve patients showed abnormal results of investigations related with common causes of chronic cough, including gastroesophageal reflux, sputum eosinophilia, bronchial hyper-responsiveness, or signs of sinusitis but did not respond to the treatments directed to those conditions. All these patients were ever misdiagnosed as other causes of chronic cough. Compared to 520 non-somatic cough syndrome patients, patients with somatic cough syndrome were younger (32 (29.0–43.0) vs 42.0 (32.0–55.0) years, p = 0.013), longer disease duration (48.0 (19.5–102.0) vs 24.0 (9.0–72.0) months, p = 0.037), more common in dry cough (100% vs 57.6%, p < 0.001), and lower proportion of nocturnal cough (13.0% vs 40.2%, p = 0.009). Common cold (60.9%) was the most common initial trigger of cough and itchy throat (60.9%) was the most common accompanying symptom in patients with somatic cough syndrome. Notably, there were similar distribution in cough triggers and accompanying symptoms between two groups. Conclusion: In spite of much higher proportion of dry cough and smaller proportion of nocturnal cough, adult patients with somatic cough syndrome show similar clinical characteristics with other chronic cough patients, in regard of cough triggers, accompanying symptoms as well as abnormal results of investigations, which should be an important reason for misdiagnosis of somatic cough syndrome. Psychiatric disorder should be addressed in clinical management of chronic cough.