bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding injecting drug use in Afghanistan: A scoping review
Authors: Nafeh Frishta , Fusigboye Sufiat , Sornpaisarn Bundit 
Published: September 2022

Abstract
Background
Several reports have described a growing prevalence of illicit drug use in Afghanistan, with recognition of a recent shift from traditional modes of consumption involving inhalation and oral ingestion to injecting drug use.

Objective
Conduct a comprehensive review of existing literature to map the injecting drug use situation in Afghanistan. The review intends to describe risk factors and impacts of injecting drug use, drug use characteristics and risk behaviours among people who inject drugs (PWID), and access to harm reduction and treatment.

Methods
We searched Embase, Global Health, Medline, PsycINFO, Web of Science, and grey literature to identify English language publications up to March 26th, 2022. Studies were eligible for inclusion if they explicitly targeted PWID or injecting drug use in Afghanistan and provided information relevant to the review questions. Two reviewers independently screened titles and abstracts for inclusion and extracted information based on the review objectives.

Results
A total of 25 articles were identified representing 15 studies (11 quantitative, 2 qualitative, 2 mixed methods). All but one studies were cross-sectional. In majority of the studies, over 95% of the participants were male and most were conducted over a decade ago, in urban settings, mainly Kabul. Only one study examined risk factors of injecting drug use. Eleven studies described drug use characteristics and 9 reported risk behaviours among PWID. Health and social burden of injecting drug use were reported by 8 and 5 studies, respectively. Nine studies described access to harm reduction and treatment. Afghan PWID had high levels of injecting and sexual risk behaviours compared to global estimates. They reported high prevalence of incarceration and displacement. Access to harm reduction and treatment was very limited. This scoping review revealed important knowledge gaps including a gender gap in research with serious implications for drug policy and substance use care.

Conclusions
Development of a national public health-oriented drug policy and substance use care programme is warranted along with efforts to develop health research capacity to address the need for epidemiological data. The current humanitarian crisis necessitates continued access to evidence-based harm reduction and treatment in Afghanistan.
ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription
Authors: Zhu Xianwei , Yan Fei , Liu Lipeng , Huang Qun 
Published: September 2022

Abstract
Background
Osteoporosis (OP) is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the role of zinc finger E-box binding homeobox 1 (ZEB1) in OP.

Methods
First, gene expression microarrays for OP were downloaded from the Gene Expression Omnibus database and analyzed to screen for potential targets. Subsequently, a rat OP model was constructed using ovariectomy (OVX), and osteoblastic and osteoclastic differentiation and alterations in osteoporotic symptoms were observed upon intraperitoneal injection of oe-ZEB1 lentiviral vectors. DNA polymerase delta interacting protein 2 (POLDIP2) was predicted to be a downstream target of ZEB1, which was validated by ChIP-qPCR and dual-luciferase experiments. RAW264.7 cells were subjected to lentiviral vector infection of oe-ZEB1 and/or sh-POLDIP2, followed by RANKL treatment to induce osteoclast differentiation.

Results
ZEB1 was poorly expressed in blood samples of postmenopausal patients with OP and in bone tissues of OVX-treated rats. Overexpression of ZEB1 or POLDIP2 in OVX rats promoted osteoblastogenesis and inhibited osteoclast differentiation. In RANKL-treated RAW264.7 cells, the transcription factor ZEB1 enhanced the expression of POLDIP2, and silencing of POLDIP2 attenuated the inhibitory effect of oe-ZEB1 on the differentiation of macrophages RAW264.7 to osteoclasts.

Conclusions
ZEB1 promotes osteoblastogenesis and represses osteoclast differentiation, ultimately reducing the occurrence of postmenopausal OP by elevating the expression of POLDIP2.
Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes
Authors: He Panpan , Gan Xiaoqin , Wu Qimeng , Ye Ziliang , Yang Sisi , Zhang Yanjun , Li Huan , Zhou Chun , Zhang Yuanyuan , Liu Mengyi , Qin Xianhui 
Published: September 2022

Abstract
Background
We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes.

Methods
Among 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality.

Results
Over a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality).

Conclusion
VVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.
Application of cardiovascular 3-dimensional printing in Transcatheter aortic valve replacement
Authors: Ma Yanyan , Mao Yu , Zhu Guangyu , Yang Jian 
Published: September 2022

AbstractTranscatheter aortic valve replacement (TAVR) has been performed for nearly 20 years, with reliable safety and efficacy in moderate- to high-risk patients with aortic stenosis or regurgitation, with the advantage of less trauma and better prognosis than traditional open surgery. However, because surgeons have not been able to obtain a full view of the aortic root, 3-dimensional printing has been used to reconstruct the aortic root so that they could clearly and intuitively understand the specific anatomical structure. In addition, the 3D printed model has been used for the in vitro simulation of the planned procedures to predict the potential complications of TAVR, the goal being to provide guidance to reasonably plan the procedure to achieve the best outcome. Postprocedural 3D printing can be used to understand the depth, shape, and distribution of the stent. Cardiovascular 3D printing has achieved remarkable results in TAVR and has a great potential.
Cost-effectiveness of strategies to control the spread of carbapenemase-producing Enterobacterales in hospitals: a modelling study
Authors: Kardaś-Słoma Lidia , Fournier Sandra , Dupont Jean-Claude , Rochaix Lise , Birgand Gabriel , Zahar Jean-Ralph , Lescure François-Xavier , Kernéis Solen , Durand-Zaleski Isabelle , Lucet Jean-Christophe 
Published: September 2022

Abstract
Background
Spread of resistant bacteria causes severe morbidity and mortality. Stringent control measures can be expensive and disrupt hospital organization. In the present study, we assessed the effectiveness and cost-effectiveness of control strategies to prevent the spread of Carbapenemase-producing Enterobacterales (CPE) in a general hospital ward (GW).

Methods
A dynamic, stochastic model simulated the transmission of CPE by the hands of healthcare workers (HCWs) and the environment in a hypothetical 25-bed GW. Input parameters were based on published data; we assumed the prevalence at admission of 0.1%. 12 strategies were compared to the baseline (no control) and combined different prevention and control interventions: targeted or universal screening at admission (TS or US), contact precautions (CP), isolation in a single room, dedicated nursing staff (DNS) for carriers and weekly screening of contact patients (WSC). Time horizon was one year. Outcomes were the number of CPE acquisitions, costs, and incremental cost-effectiveness ratios (ICER). A hospital perspective was adopted to estimate costs, which included laboratory costs, single room, contact precautions, staff time, i.e. infection control nurse and/or dedicated nursing staff, and lost bed-days due to prolonged hospital stay of identified carriers. The model was calibrated on actual datasets. Sensitivity analyses were performed.

Results
The baseline scenario resulted in 0.93 CPE acquisitions/1000 admissions and costs 32,050 €/1000 admissions. All control strategies increased costs and improved the outcome. The efficiency frontier was represented by: (1) TS with DNS at a 17,407 €/avoided CPE case, (2) TS + DNS + WSC at a 30,700 €/avoided CPE case and (3) US + DNS + WSC at 181,472 €/avoided CPE case. Other strategies were dominated. Sensitivity analyses showed that TS + CP might be cost-effective if CPE carriers are identified upon admission or if the cases have a short hospital stay. However, CP were effective only when high level of compliance with hand hygiene was obtained.

Conclusions
Targeted screening at admission combined with DNS for identified CPE carriers with or without weekly screening were the most cost-effective options to limit the spread of CPE. These results support current recommendations from several high-income countries.
Quantification of Campylobacter contamination on chicken carcasses sold in retail markets in the United Arab Emirates
Authors: Habib Ihab , Mohamed Mohamed-Yousif Ibrahim , Lakshmi Glindya Bhagya , Khan Mushtaq , Li Dan 
Published: September 2022

Abstract
Background
Campylobacter is among the leading causes of foodborne zoonotic disease worldwide, with chicken meat accounting for the majority of human illnesses. This baseline study generates the first quantitative data for Campylobacter contamination in the United Arab Emirates chicken meat. Such data will help inform risk analysis and develop evidence-based food safety management.

Methods
For a year, chilled whole chicken carcasses (n = 315) belonging to seven different companies were collected from retail supermarkets. According to standard methods, Campylobacter enumeration was achieved by a direct plating in all chicken samples, and isolates were confirmed using multiplex PCR.

Results
Campylobacter spp. were recovered from 28.6% (90/315) of the samples. Campylobacter enumeration results indicated that 71.4% of the tested samples were contaminated with < 1 log10 CFU (colony-forming units)/g, and 7% were contaminated with ≥3 log10 CFU/g. The mean Campylobacter concentration was 2.70 log10 CFU/g, with a standard deviation of 0.41 log10 CFU/g. Campylobacter counts varied significantly in relation to the sourcing chicken processing companies. Six out of the seven surveyed companies provided Campylobacter positive samples. Moreover, significantly higher (p-value< 0.0001) counts were found to be associated with smaller size chicken carcasses (weighted 600–700 g; compared to the other categories, 800 g and 900–1000 g). Interestingly, C. coli was present in 83% of the positive samples, while C. jejuni was only detected in 6.4% of the samples. Compared with studies from other countries utilizing the same enumeration method, the UAE chicken appears to have a lower prevalence but a higher Campylobacter count per gram of carcasses. Higher Campylobacter counts were significantly associated with smaller carcasses, and C. coli was the dominant species detected in this study’s samples.

Conclusion
These results add to our understanding of the local, regional and global epidemiology of Campylobacter in chicken meat. Outputs of the current study may aid in developing a risk assessment of Campylobacter in the UAE, a country among the biggest per capita consumption markets for chicken meat worldwide.
Ionospheric electron density modelling using B-splines and constraint optimization
Authors: Lalgudi Gopalakrishnan Ganesh , Schmidt Michael 
Published: September 2022

Abstract
Many modern applications, such as precise point positioning, autonomous driving or precision agriculture would benefit significantly if a high-precision and high-resolution model of electron density in the ionosphere and the plasmasphere would be globally available. Since the development of such a model still relies on data with insufficient and uneven global coverage, the consideration of background information and the introduction of equality and inequality constraints on Chapman key parameters are essential. In this work, we develop a multi-layer Chapman model based on B-spline expansions of selected key parameters of the electron density. The unknown series coefficients of the key parameters are subject to equality and inequality constraints. Finally, the developed model is applied to a combination of real and semi-simulated input data; the results are validated through ionosonde measurements.

Graphical Abstract
Multi-GNSS clock combination with consideration of inconsistent nonlinear variation and satellite-specific bias
Authors: Chen Guo , Guo Jing , Wei Na , Li Min , Zhao Qile , Tao Jun 
Published: September 2022

AbstractAs part of the International GNSS Service (IGS) multi-GNSS Pilot Project (MGEX), precise orbit and clock products for multi-GNSS constellations have been submitted by several analysis centers (ACs) since 2012. Based on the 30 s satellite clocks from 6 MGEX ACs, the multi-GNSS clocks are combined and the consistency of the AC clocks is assessed in this study. Usually, a linear transformation between the combined and AC solution is used for clock combination, and the clock residuals of the AC solution w.r.t the combined solution are used to determine the weights of the AC. However, any inconsistent satellite-specific bias or nonlinear variations in the clocks induced by the AC’s processing strategy can contaminate the linear transformation as well as the determination of the weight. In this study, the analysis center and satellite-specific bias (ASB) of the MGEX AC clock solutions is first identified and estimated by using observations from globally distributed stations. Moreover, the clock solutions with nonlinear variations induced by the reference clock or nonconstant intersystem bias (ISB) are corrected by aligning the clocks to the selected reference solution before clock combination. With the correction of the ASB, the root-mean-square of the clock residuals decreases significantly and reaches 14$$-$$
-
26, 37$$-$$
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91, 33$$-$$
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48 and 12$$-$$
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44 ps for GPS, GLONASS, BDS-2 and Galileo, respectively. In general, the consistency of AC solutions w.r.t the combination reaches 8$$-$$
-
16, 27$$-$$
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58, 13$$-$$
-
27 and 9$$-$$
-
36 ps for GPS, GLONASS, BDS-2 and Galileo in terms of the standard deviation. Finally, the individual AC and combined orbit as well as clock solutions of different constellations are assessed by precise point positioning, and the combined multi-GNSS solutions show competitive performance with the best AC solution in terms of both the positioning accuracy and stability of the reference frame parameters. However, inconsistent scale parameters of both the AC and combined solutions are identified and require more investigation.
Graphical Abstract
Association between adherence to the dietary approaches to stop hypertension (DASH) diet and maternal and infant sleep disorders
Authors: Karbasi Samira , Azaryan Ehsaneh , Zangooie Alireza , Zarban Asghar , Bahrami Afsane 
Published: September 2022

Abstract
Background
Maternal diet is known to be important to both mother and infant health. The purpose of this study was to evaluate the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern (DP) and sleep problems in mothers and their infants.

Methods
The study included 350 breastfeeding mothers with an average age of 29.5 ± 5.9 years. Psychological functions were performed using standard questionnaires, including a Quality-of-Life Questionnaire (QLQ), Edinburgh Postnatal Depression Scale (EPDS), Spielberger Anxiety Questionnaire (SAQ), Pittsburg Sleep Quality Index (PSQI), and Infant Sleep Questionnaire (ISQ). Also, a standardized food frequency questionnaire (FFQ) was used to identify adherence to the DASH DP.

Results
Subjects in the highest tertile of DASH DP had significantly lower scores of mother’s sleep latency (0.70 ± 1.18 vs. 1.24 ± 1.3; P value = 0.031), sleep disorders (4.3 ± 1.6 vs. 5.3 ± 2.4; P value= 0.032) and higher mother sleep efficiency compared to those in the lowest tertile (97.5 ± 89 vs. 54.8 ± 90; P value= 0.011). Also, infants of mothers with higher adherence to a DASH DP had lower sleep disorders compared with subjects with low adherence (4.9 ± 3.8 vs. 5.7 ± 3.2; P value= 0.017). After controlling for the mother’s education, economic status, age, body mass index (BMI), and energy intake, adherence to the DASH pattern was associated with shorter sleep latency (β = 0.60; 95%CI: 0.49–0.82), fewer sleep disorders score in mothers (β = 0.92; 95%CI: 0.85–0.99) and their infants (β = 0.90; 95%CI: 0.84–0.96) as well as high mother’s sleep efficiency (β = 1.2; 95%CI: 1.1–1.31).

Conclusions
According to our findings, adherence to DASH DP is associated with a lower score for sleep disorders in mothers and their infants.
Evaluation of the performance of GNSS-based velocity estimation algorithms
Authors: Ji Li , Sun Rui , Cheng Qi , Wang Junhui 
Published: September 2022

AbstractGlobal Navigation Satellite System (GNSS) based velocity estimation is one of the most cost-effective and widely used methods in determining velocity in geodesy and transport applications. Highly accurate and reliable velocity measurements can be obtained by exploiting the raw Doppler, carrier phase, and pseudorange measurements with a GNSS receiver. There are several approaches to GNSS-based velocity determination. This paper investigates the characteristics of the approaches which are currently popular and applicable to the observations of Global Positioning System (GPS), BeiDou Navigation Satellite System (BDS), and their combination (GPS/BDS). Specifically, it evaluates the performance of the velocity estimated based on the Raw Doppler method, the Time-Differenced Pseudorange method, the Time-Differenced Carrier Phase method, and the Double-Differenced Carrier Phase method, in both static and dynamic modes and in open and urban scenarios. The experiments show that BDS has the advantages in delivering accurate velocity determinations over GPS in the Asia–Pacific region, and the effectiveness of the GPS/BDS in improving the overall accuracy of velocity determination in complex urban scenarios.
Selpercatinib in Patients With RET Fusion–Positive Non–Small-Cell Lung Cancer: Updated Safety and Efficacy From the Registrational LIBRETTO-001 Phase I/II Trial
Authors: Drilon Alexander , Subbiah Vivek , Gautschi Oliver , Tomasini Pascale , de Braud Filippo , Solomon Benjamin J. , Shao-Weng Tan Daniel , Alonso Guzmán , Wolf Jürgen , Park Keunchil , Goto Koichi , Soldatenkova Victoria , Szymczak Sylwia , Barker Scott S. , Puri Tarun , Bence Lin Aimee , Loong Herbert , Besse Benjamin 
Published: September 2022

PURPOSE Selpercatinib, a first-in-class, highly selective, and potent CNS-active RET kinase inhibitor, is currently approved for the treatment of patients with RET fusion–positive non–small-cell lung cancer (NSCLC). We provide a registrational data set update in more than double (n = 316) of the original reported population (n = 144) and better characterization of long-term efficacy and safety. METHODS Patients were enrolled to LIBRETTO-001, a phase I/II, single-arm, open-label study of selpercatinib in patients with RET-altered cancers. An analysis of patients with RET fusion–positive NSCLC, including 69 treatment-naive and 247 with prior platinum-based chemotherapy, was performed. The primary end point was objective response rate (ORR; RECIST v1.1, independent review committee). Secondary end points included duration of response (DoR), progression-free survival (PFS), overall survival, and safety. RESULTS In treatment-naive patients, the ORR was 84% (95% CI, 73 to 92); 6% achieved complete responses (CRs). The median DoR was 20.2 months (95% CI, 13.0 to could not be evaluated); 40% of responses were ongoing at the data cutoff (median follow-up of 20.3 months). The median PFS was 22.0 months; 35% of patients were alive and progression-free at the data cutoff (median follow-up of 21.9 months). In platinum-based chemotherapy pretreated patients, the ORR was 61% (95% CI, 55 to 67); 7% achieved CRs. The median DoR was 28.6 months (95% CI, 20.4 to could not be evaluated); 49% of responses were ongoing (median follow-up of 21.2 months). The median PFS was 24.9 months; 38% of patients were alive and progression-free (median follow-up of 24.7 months). Of 26 patients with measurable baseline CNS metastasis by the independent review committee, the intracranial ORR was 85% (95% CI, 65 to 96); 27% were CRs. In the full safety population (n = 796), the median treatment duration was 36.1 months. The safety profile of selpercatinib was consistent with previous reports. CONCLUSION In a large cohort with extended follow-up, selpercatinib continued to demonstrate durable and robust responses, including intracranial activity, in previously treated and treatment-naive patients with RET fusion–positive NSCLC.