bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating palliative care and heart failure: a protocol for a realist synthesis (PalliatHeartSynthesis)
Authors: McConnell Tracey , Burden John , Duddy Claire , Hill Loreena , Howie Clare , Jones Bob , Ruane Bob , Wong Geoff , Reid Joanne 
Published: January 2022

IntroductionHeart failure affects over 26 million people worldwide with prevalence expected to grow due to an ageing global population. Palliative care can address the holistic needs of patients with heart failure, and integrated palliative care in heart failure management has been indicated to improve outcomes for patients. Despite known benefits for integrated palliative care in heart failure management, implementation is poor across the majority of global health services. Recent systematic reviews have identified the benefits of integrating palliative care into heart failure management and highlighted barriers to implementation. However, there was heterogeneity in terms of countries, healthcare settings, delivery by differing staff across multidisciplinary teams, modes of delivery and different intervention components.Methods and analysisThe aim of this study is to identify how integrated palliative care and heart failure interventions produce desired outcomes, in which contexts, and for which patients. We will undertake a realist synthesis to identify this, using Pawson’s five iterative steps. We will recruit an international stakeholder group comprised of healthcare providers and patients with heart failure to advise and provide feedback throughout the review. Our initial realist programme theory sets out the necessary steps needed to accomplish the final intended outcome(s) from the implementation of integrated palliative care and heart failure. This initial programme theory will be shaped through an iterative process of testing and refinement.Ethics and disseminationEthical approval is not required for this study. With our stakeholder group, we will coproduce a user guide that outlines practical advice to optimise, tailor and implement interventions designed to integrate palliative care and heart failure, taking into consideration local context, alongside user-friendly summaries of the synthesis findings using short animations to convey complex findings. We will draw on the expertise within the stakeholder group to identify key stakeholders for disseminating to relevant audiences, ensuring outputs are tailored for their respective needs.PROSPERO registration numberCRD42021240185.
Blocking hepatocarcinogenesis by a cytochrome P450 family member with female-preferential expression
Authors: Ji Fubo , Zhang Jianjuan , Liu Niya , Gu Yuanzhuo , Zhang Yan , Huang Peipei , Zhang Nachuan , Lin Shengda , Pan Ran , Meng Zhuoxian , Feng Xin-Hua , Roessler Stephanie , Zheng Xin , Ji Junfang 
Published: January 2022

ObjectsThe incidence of hepatocellular carcinoma (HCC) shows an obvious male dominance in rodents and humans. We aimed to identify the key autosomal liver-specific sex-related genes and investigate their roles in hepatocarcinogenesis.DesignTwo HCC cohorts (n=551) with available transcriptome and metabolome data were used. Class comparisons of omics data and ingenuity pathway analysis were performed to explore sex-related molecules and their associated functions. Functional assays were employed to investigate roles of the key candidates, including cellular assays, molecular assays and multiple orthotopic HCC mouse models.ResultsA global comparison of multiple omics data revealed 861 sex-related molecules in non-tumour liver tissues between female and male HCC patients, which denoted a significant suppression of cancer-related diseases and functions in female liver than male. A member of cytochrome P450 family, CYP39A1, was one of the top liver-specific candidates with significantly higher levels in female vs male liver. In HCC tumours, CYP39A1 expression was dramatically reduced in over 90% HCC patients. Exogenous CYP39A1 significantly blocked tumour formation in both female and male mice and partially reduced the sex disparity of hepatocarcinogenesis. The HCC suppressor role of CYP39A1 did not rely on its known P450 enzyme activity but its C-terminal region, by which CYP39A1 impeded the transcriptional activation activity of c-Myc, leading to a significant inhibition of hepatocarcinogenesis.ConclusionsThe liver-specific CYP39A1 with female-preferential expression was a strong suppressor of HCC development. Strategies to up-regulate CYP39A1 might be promising methods for HCC treatment in both women and men in future.
Association of education levels with the risk of hypertension and hypertension control: a nationwide cohort study in Chinese adults
Authors: Sun Kan , Lin Diaozhu , Li Mian , Mu Yiming , Zhao Jiajun , Liu Chao , Bi Yufang , Chen Lulu , Shi Lixin , Li Qiang , Yang Tao , Wan Qin , Wu Shengli , Wang Guixia , Luo Zuojie , Qin Yingfen , Tang Xulei , Chen Gang , Huo Yanan , Gao Zhengnan , Su Qing , Ye Zhen , Hu Ruying , Wang Youmin , Qin Guijun , Deng Huacong , Yu Xuefeng , Shen Feixia , Chen Li , Wang Weiqing , Ning Guang , Yan Li 
Published: January 2022

BackgroundEducation attainment can improve life expectancy and guide healthy behaviours throughout an entire lifetime. A nationwide longitudinal study of the association of education status with the risk of hypertension and its control in China is lacking.MethodsThe China Cardiometabolic Disease and Cancer Cohort Study is a multicentre, population-based, prospective cohort study. We performed the baseline survey from 2011 to 2012. A follow-up visit was conducted during 2014–2016. 101 959 subjects were included in the final data analyses. Cox proportional hazards regression was used to examine the associations of education levels with the risk of hypertension and uncontrolled hypertension.ResultsDuring follow-up, 11 189 (19.9%) participants had developed hypertension among subjects without hypertension at baseline. Among the participants with hypertension at baseline, only 40.6% had controlled hypertension. Compared with the participants’ education level at elementary school and below, the multivariable-adjusted HR for incident hypertension was 0.76 (95% CI, 0.72 to 0.80) in those with a middle school education level and 0.67 (95% CI, 0.63 to 0.70) in those with a high school degree or above. Correspondingly, multivariable-adjusted HRs associated with uncontrolled hypertension were 0.90 (95% CI, 0.87 to 0.92) in participants with a middle school education level and 0.85 (95% CI, 0.82 to 0.88) in participants with a high school degree or above level.ConclusionParticipants with education attainment at elementary school and below exhibited excess risks of newly diagnosed hypertension and worse blood pressure control compared with individuals with education attainment at middle school or above.
Maternal educational inequalities about adverse pregnancy outcomes observed in a rural area of a province of China during a time period (2010–2018)
Authors: Li Lixin , Wu Yanpeng , Yang Yao , Wu Ying , Zhuang Yan , You Dingyun 
Published: January 2022

BackgroundThe relationship between maternal education and adverse pregnancy outcomes is well documented. However, limited research has investigated maternal educational disparities in adverse pregnancy outcomes in China. This study examined maternal educational inequalities associated with adverse pregnancy outcomes in rural China.MethodsWe conducted a population-based cohort study using participants enrolled in the National Free Preconception Health Examination Project in Yunnan province from 2010 to 2018. The primary outcome was stillbirth, and the secondary outcome was adverse pregnancy outcomes, defined as a composite event of stillbirth, preterm birth or low birth weight. The study was restricted to singleton births at 20–42 weeks’ gestation. Univariate and multivariate log-binomial regression models were performed to estimate crude risk ratios (RRs) and confounding-adjusted RRs (ARRs) for stillbirth and adverse pregnancy outcomes according to maternal education level.ResultsA total of 197 722 singleton births were included in the study. Compared with mid-educated women, low-educated women were at a significantly increased risk of stillbirth (ARR, 1.20; 95% CI, 1.05 to 1.38) and adverse pregnancy outcomes (ARR, 1.11; 95% CI, 1.07 to 1.16). However, the risk of stillbirth (ARR, 1.16; 95% CI, 1.01 to 1.35) was significantly higher for high-educated women compared with mid-educated women.ConclusionCompared with women with medium education level, women with lower education level were more likely to experience adverse pregnancy outcomes, including stillbirth, and women with higher education level were more likely to experience stillbirth.
High-dose rifamycins in the treatment of TB: a systematic review and meta-analysis
Authors: Arbiv Omri A , Kim JeongMin M , Yan Marie , Romanowski Kamila , Campbell Jonathon R , Trajman Anete , Asadi Leyla , Fregonese Federica , Winters Nicholas , Menzies Dick , Johnston James C 
Published: January 2022

BackgroundThere is growing interest in using high-dose rifamycin (HDR) regimens in TB treatment, but the safety and efficacy of HDR regimens remain uncertain. We performed a systematic review and meta-analysis comparing HDR to standard-dose rifamycin (SDR) regimens.MethodsWe searched MEDLINE, Embase, CENTRAL, Cochrane Database of Systematic Reviews and clinicaltrials.gov for prospective studies comparing daily therapy with HDRs to SDRs. Rifamycins included rifampicin, rifapentine and rifabutin. Our primary outcome was the rate of severe adverse events (SAEs), with secondary outcomes of death, all adverse events, SAE by organ and efficacy outcomes of 2-month culture conversion and relapse. This study was prospectively registered in the International Prospective Register of Systematic Reviews (CRD42020142519).ResultsWe identified 9057 articles and included 13 studies with 6168 participants contributing 7930 person-years (PY) of follow-up (HDR: 3535 participants, 4387 PY; SDR: 2633 participants, 3543 PY). We found no significant difference in the pooled incidence rate ratio (IRR) of SAE between HDR and SDR (IRR 1.00, 95% CI 0.82 to 1.23,I2=41%). There was no significant difference when analysis was limited to SAE possibly, probably or likely medication-related (IRR 1.07, 95% CI 0.82 to 1.41,I2=0%); studies with low risk of bias (IRR 0.98, 95% CI 0.79 to 1.20,I2=44%); or studies using rifampicin (IRR 1.00, 95% CI 0. 0.75–1.32,I2=38%). No significant differences were noted in pooled outcomes of death, 2-month culture conversion and relapse.ConclusionsHDRs were not associated with a significant difference in SAEs, 2-month culture conversion or death. Further studies are required to identify specific groups who may benefit from HDR.
Forming molecular states with hadronic rescattering
Authors: Ilten Philip , Utheim Marius 
Published: January 2022

AbstractA method for modelling the prompt production of molecular states using the hadronic rescattering framework of the general-purpose Pythia event generator is introduced. Production cross sections of possible exotic hadronic molecules via hadronic rescattering at the LHC are calculated for the $$\chi _{c1}(3872)$$

χ

c
1

(
3872
)

resonance, a possible tetraquark state, as well as three possible pentaquark states, $$P_c^+(4312)$$

P
c
+

(
4312
)

, $$P_c^+(4440)$$

P
c
+

(
4440
)

, and $$P_c^+(4457)$$

P
c
+

(
4457
)

. For the $$P_c^+$$

P
c
+

states, the expected cross section from $$\Lambda _b$$

Λ
b

decays is compared to the hadronic-rescattering production. The $$\chi _{c1}(3872)$$

χ

c
1

(
3872
)

cross section is compared to the fiducial $$\chi _{c1}(3872)$$

χ

c
1

(
3872
)

cross-section measurement by LHCb and found to contribute at a level of $${\mathcal {O}({1\%})}$$

O
(

1
%

)

. Finally, the expected yields of $$\mathrm {P_c^{+}}$$

P
c
+

production from hadronic rescattering during Run 3 of LHCb are estimated. The prompt background is found to be significantly larger than the prompt $$\mathrm {P_c^{+}}$$

P
c
+

signal from hadronic rescattering.
A quantum bound on the compactness
Authors: Casadio Roberto 
Published: January 2022

AbstractWe present a simple quantum description of the gravitational collapse of a ball of dust which excludes those states whose width is arbitrarily smaller than the gravitational radius of the matter source and supports the conclusion that black holes are macroscopic extended objects. We also comment briefly on the relevance of this result for the ultraviolet self-completion of gravity and the connection with the corpuscular picture of black holes.
FCC-ee overview: new opportunities create new challenges
Authors: Blondel Alain , Janot Patrick 
Published: January 2022

AbstractWith its high luminosity, its clean experimental conditions, and a range of energies that cover the four heaviest particles known today, FCC-ee offers a wealth of physics possibilities, with high potential for discoveries. The FCC-ee is an essential and complementary step towards a 100 TeV hadron collider, and as such offers a uniquely powerful combined physics program. This vision is the backbone of the 2020 European Strategy for Particle Physics. One of the main challenges is now to design experimental systems that can, demonstrably, fully exploit these extraordinary opportunities.
Electrochemical Pulsing Deposition of CTZS (Optical and Structural properties) Solar Energy Applications
Authors: Saeed Mahfouz Ali 
Published: January 2022

Cu2(ZnSn)(S)4 (CTZS) has number of advantages over other solar this film such as CuInGaSe2 (CIGS) due to its higher band gap. Generating such thin film layers by electrochemical methods is particularly attractive because the lower generating budget and the higher throughput. According to literature it is default with many challenges to produce CTZS from electrodeposition methods due to wide range of standard potential of each elements of CTZS 1-4. Sulfur atomic ratio is about 50% of CTZS alloy which add more complexity to electrochemical processing.
We introduce in this work electropulsing techniques on order to electroplate at transient current instead of steady state current. Electrolyte composition was similar to dilute concentration from the previous work which is is considerably more dilute in comparison to conventional electrolytes used in the literature1-4. The bath composition is: 0.0042 M CuSO4, 0.0031 M ZnSO4, 0.035 M SnCl2, 0.005 M Na2S2O3, and 0.045 M Na2S2O3. PHydrion is used to buffer the electrolyte to pH=2, and supporting electrolyte is 0.6 M LiCl.
Experiments was conducted at a rotating disk electrode which offers measureable characterization of the rotating flow at room temperature. Electrochemical pulsing current behavior study at different off and on time and current in Fig. 1 and 2. The effects of pulsing time and current density on the CTZS thin film adhesion and atomic composition are discussed. The annealing was carried out on tube furnace under sulfur element atmosphere with no extra material addition. The amount of sulfur on the absorber layer was optimized. The alloy composition was examined using Energy-dispersive X-ray spectroscopy technique (EDS) Fig. 2. XRD analysis method used to characterized CTZS thickness and crystallography.

Figure 1
Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon
Authors: Kang Thierry Roland , Dinga Jerome Nyhalah , Orock Ayuk Elizabeth , Monya Elvis , Ngemenya Moses Njutain 
Published: January 2022

Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations. In particular, they are efficacious against microfilariae (microfilaricidal) with no activity against adult worms (nonmacrofilaricidal). Promising anthelmintic activity has been reported in some lichens. This study investigated three lichens, Usnea articulata, Parmotrema tinctorum, and Heterodermia obscurata, found on Mount Cameroon, for potential macrofilaricidal activity. Organic extracts were screened for anti-Onchocerca activity against Onchocerca ochengi isolated from cattle skin using worm motility and MTT formazan assays. Toxicity of highly active extracts was investigated on monkey kidney epithelial (LLCMK2) cells and in BALB/c mice (2000 mg/kg body weight) including effects on liver enzymes. The methanol extract of P. tinctorum (Pammet) was the most active against adult male worms (

I

C

50

=
8.1

μg/mL) with the highest selectivity index (

SI
=
21.3

). U. articulata was the most active against the adult female (

I

C

50

=
36.3

μg/mL) but had a low SI value (3.4). No mortality and no adverse effects were recorded in the acute toxicity test. These two most active extracts had no significant effect on liver enzymes, alanine aminotransferase, and aspartate (

P

values < 0.05), but a high AST : ALT ratio (2.59) for Pammet indicates likely reversible adverse hepatic toxicity. The high macrofilaricidal activity and selectivity of P. tinctorum suggest it is a potential source of new macrofilaricides which should be further investigated to identify its bioactive constituents.
The IoT and registration of MRI brain diagnosis based on genetic algorithm and convolutional neural network
Authors: Ahmed Ahmed Shihab , Salah Hussein Ali 
Published: January 2022

The technology <span>of the multimodal brain image registration is the key method for accurate and rapid diagnosis and treatment of brain diseases. For achieving high-resolution image registration, a fast sub pixel registration algorithm is used based on single-step discrete wavelet transform (DWT) combined with phase convolution neural network (CNN) to classify the registration of brain tumors. In this work apply the genetic algorithm and CNN clasifcation in registration of magnetic resonance imaging (MRI) image. This approach follows eight steps, reading the source of MRI brain image and loading the reference image, enhencment all MRI images by bilateral filter, transforming DWT image by applying the DWT2, evaluating (fitness function) each MRI image by using entropy, applying the genetic algorithm, by selecting the two images based on rollout wheel and crossover of the two images, the CNN classify the result of subtraction to normal or abnormal, “in the eighth one,” the Arduino and global system for mobile (GSM) 8080 are applied to send the message to patient. The proposed model is tested on MRI Medical City Hospital in Baghdad database consist 550 normal and 350 abnormal and split to 80% training and 20 testing, the proposed model result achieves the 98.8% </span>accuracy.
A new remote monitoring device to track magnetic resonance imaging machine cooling system failures
Authors: Elallam Oussama , Hamlich Mohamed 
Published: January 2022

The magnetic resonance imaging (MRI) machine cooling system has a vital role in the conduct of MRI examinations because a shutdown of the MRI cooling system in the absence of the manipulators can lead to grave consequences over time, like quench, which is the vaporization of helium liquid in the MRI tank, and it's the most expensive MRI failure. To limit the risks of this problem, several companies have tried to develop a monitoring system to track MRI cooling system failures but all solutions proposed are complicated and demand many connections with MRI. The proposed solution is simple, easy, and efficient requires only one joint with the helium compressor, and it has a humidity and temperature sensor to detect quench incident, it works using an advanced monitoring algorithm that evaluates the status of the cooling system and identifies breakdowns, in case of failure our system will send short message service (SMS) notifications and emails to the customer service team. The proposed solution shows the potential for starting the research to understand the relationship between the behavior of the MRI cooling system and the quench using machine learning algorithms.
Multi-scale 3D-convolutional neural network for hyperspectral image classification
Authors: Kanthi Murali , Sarma Thogarcheti Hitendra , Bindu Chigarapalle Shoba 
Published: January 2022

Deep Learning methods are state-of-the-art approaches for pixel-based hyperspectral images (HSI) classification. High classification accuracy has been achieved by extracting deep features from both spatial-spectral channels. However, the efficiency of such spatial-spectral approaches depends on the spatial dimension of each patch and there is no theoretically valid approach to find the optimum spatial dimension to be considered. It is more valid to extract spatial features by considering varying neighborhood scales in spatial dimensions. In this regard, this article proposes a deep convolutional neural network (CNN) model wherein three different multi-scale spatial-spectral patches are used to extract the features in both the spatial and spectral channels. In order to extract these potential features, the proposed deep learning architecture takes three patches various scales in spatial dimension. 3D convolution is performed on each selected patch and the process runs through entire image. The proposed is named as multi-scale three-dimensional convolutional neural network (MS-3DCNN). The efficiency of the proposed model is being verified through the experimental studies on three publicly available benchmark datasets including Pavia University, Indian Pines, and Salinas. It is empirically proved that the classification accuracy of the proposed model is improved when compared with the remaining state-of-the-art methods.
Assessment of the Quality of Arabica Coffee Beans from Three Processing Methods and Two Types of Packaging Materials
Authors: Dharmaputra Okky S. , Ambarwati Santi , Retnowati Ina , Nurfadila Nijma 
Published: January 2022

In Southeast Asia, Indonesia is the second highest-producing country of coffee beans after Vietnam. Consequently, Indonesia competes with other countries in producing good quality coffee beans. However, not many people have sufficient skills in tackling problems related to the postharvest handling of these coffee beans. The objective of this study was to assess the quality of Arabica coffee (Coffea arabica) beans in terms of moisture content, fungal infection (especially ochratoxin A or OTA producing fungi), OTA contamination, and the taste of the coffee during storage. The three processing methods used were dry, wet, and semi-wet methods. The beans were packed using two types of packaging materials, i.e. Kantong Semar high gas barrier and polypropylene bags (4 kg/bag). They were then stored under warehouse conditions during 4 months of storage. The moisture content of coffee beans processed using the three methods and packed using polypropylene bags was higher than that of coffee beans packed using Kantong Semar high gas barrier; however, it was still lower than the safe moisture content for coffee determined by the Indonesian National Standard (12.5%). Aspergillus niger was found in coffee processed using the three methods and packed using a Kantong Semar high gas barrier. Its population was relatively low (< 0.1 x 10 cfu/g wet basis). Aspergillus ochraceus was found in coffee processed using dry and wet methods at the beginning of storage. Its population was also relatively low (< 0.3 x 10 cfu/g w.b. OTA content was not detected in all coffee samples, because it was lower than the detection limit of the instrument used (< 1.85 ppb). At the beginning of the storage, all coffee samples were dominated by yeast with the population of 1.9 x 102 – 1.2 x 103 cfu/g w.b. The taste of coffee in various treatments during 4 months of storage was still above the total standard score for specialty grade ≥ 80. The highest total score (84) was found in coffee beans processed using a dry method and packed in Kantong Semar high gas barrier. The three processing methods and the two types of packaging materials can be used to maintain the quality of coffee beans during 4 months of storage.

Keywords: Arabica coffee beans, processing methods, quality, types of packaging materials