bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver Microabscesses in a Premature Neonate With Eosinophilic Colitis
Authors: Parks Olivia B. , Keith Mary , Squires Judy H. , Venkat Veena L. , Mahmood Burhan 
Published: July 2022

ABSTRACT
Hepatic abscesses in premature infants are rare with less than 100 case reports documented in literature. We report a case of a premature infant diagnosed with hepatic microabscesses secondary to eosinophilic colitis. A 33 4/7-week preterm female neonate presented with bilious emesis, abdominal distention, and severe hematochezia. Eosinophilic enterocolitis was suspected. Hypoechoic regions in the anterior liver identified on computed tomography were considered liver microabscesses. This unique case exemplifies how prematurity increases the risk of mucosal damage in the presence of eosinophilic colitis causing enteric bacteria to seed into the liver through the portal vein, resulting in hepatic microabscesses.
KONSEP PEMERINTAHAN BAKRI SYAHID DALAM TAFSIR AL-HUDA TAFSIR QUR’AN BASA JAWI
Authors: Zaelani Thoriq Fadli 
Published: July 2022

Abstract Government is important in carrying out a life in the nation and state, in order to achieve the welfare of the world and the hereafter, both materially and spiritually. This study aims to examine the concept of government according to Bakri Syahid in Al-Huda's interpretation and to reveal how Bakri Shahid interprets the government verses. The method used is the description method in which the researcher describes regularly the thought conception of the character, including the biography of the character and the theory of literary interpretation of the Qur'an (al-tafsîr al-adabî li al-Qur’an) as a knife of analysis initiated by Amîn al-khûlî. The results of this study prove that there are five main concepts of government according to Bakri syahid in Al-Huda's interpretation, these concepts are: the concept of divinity, the concept of humanity, the concept of unity, the concept of deliberation and the concept of justice. However, in interpreting the verses of Bakri Shahid's government, he was greatly influenced by his scientific and professional background, as well as the influence of the social and cultural background of his time. Keywords: government; interpretation; justiceAbstrak Pemerintahan merupakan hal yang penting dalam menjalankan suatu kehidupan dalam berbangsa dan bernegara, demi tercapainnya kesejahteraan dunia maupun akhirat, baik dalam matrial maupun sepiritual. Penelitian ini berupaya untuk mengkaji konsep pemerintahan menurrut Bakri Syahid dalam tafsir Al-Huda dan untuk mengungkap bagaimana penafsiran Bakri Syahid terhadap ayat-ayat pemerintahan. Metode yang digunakan adalah metode deskripsi dimana peneliti menguraikan secara teratur konsepsi pemikiran dari tokoh, termasuk di dalamnya adalah biografi dari tokoh tersebut dan teori tafsir sastra terhadap al-Qur’an (al-tafsîr al-adabî li al-Qur’an) sebagai pisau analisanya yang digagas oleh Amîn al-khûlî. Hasil penelitian ini membuktikan bahwa, ada lima pokok yang menjadi konsep pemerintahan menurut Bakri syahid dalam tafsir Al-Huda, konsep-konsep tersebut adalah: konsep ketuhanan, konsep kemanusiaan, konsep persatuan, konsep musyawarah dan konsep keadilan. Sedangkan dalam menafsirkan ayat-ayat pemerintahan Bakri Syahid sangat dipengaruhi oleh latar belakang keilmuan dan profesi yang ia jalani, serta pengaruh dari latar belakang kehidupan sosiaal dan budaya pada masa nya. Kata Kunci: pemerintah; tafsir; keadilan
Effects of photoperiod and temperature on ecophysiological responses of Ericaria barbatula (Phaeophyceae): a long-term study
Authors: Papadimitriou Apostolos , Nakou Konstantinia , Papathanasiou Vasillis , Orfanidis Sotiris 
Published: July 2022

Abstract
The photoperiod alone or in combination with temperature may affect macroalgal growth, reproduction, and development. This study aimed to investigate the responses of Ericaria barbatula, a perennial fucalean species collected from Kavala Gulf, Greece, to photoperiod and temperature. Maximum quantum yield (F

v
/F

m
), wet biomass (g), relative growth rate (day−1), and reproduction (receptacles and zygote formation) were monitored in two laboratory experiments, the first one in two consecutive phases (A and B), that lasted at least seven months. While in Experiment 1, phase A, specimens were cultivated under long-day (LD) and short-day (SD) conditions at a constant temperature, in Experiment 1, phase B, they were cultivated at a seasonally changing temperature. The results indicated that E. barbatula reproduced in both phases under SD conditions and grew better in winter to early spring under seasonally changing temperatures. The cultivation under night-break (NB) daylength and seasonally changing temperatures (Experiment 2) indicated that E. barbatula is a facultative (quantitative) SD plant, a result that needs further examination. However, the induction of reproductive organs under SD conditions has been confirmed. It secures the release of zygotes and the germlings’ growth in the field from April to June/July under non-stressful Mediterranean Sea temperatures.
Microsoft 365 as a Tool for Teaching During the Covid-19 Pandemic: Perceptions of Portuguese Teachers of Basic and Secondary Education
Authors: Escola Joaquim , Lopes Natália , Catarino Paula , Aires Ana Paula 
Published: July 2022

Abstract
In the last year, and largely due to the pandemic situation of COVID-19, teachers experimented with technology in an innovative way not only to keep students engaged, but also to make learning more active and more significant. The Microsoft 365 was one of the solutions that provided schools, teachers and students with all the necessary resources to continue teaching and learning in a remote mode. In this work, we present a study that aims to know the opinions of several teachers about the use they made of Microsoft 365 during distance education and to know the degree of satisfaction obtained with its use. The adopted method has a descriptive and exploratory nature, focusing on a quantitative paradigm. The study participants were 101 teachers of basic1 and secondary education2 from schools in Northern Portugal. A questionnaire survey was used as a data collection instrument, which was mainly disseminated by email from Outlook. Data analysis was performed using Excel (Office 2016). The results suggest that Microsoft 365 was the appropriate response to the constraints imposed by the pandemic, and that most respondents revealed a high level of satisfaction with its use, despite not having much training in the use of teaching platforms.
Association between TP53 Arg72Pro variant and recurrent pregnancy loss in the Greek population
Authors: Dedousi Dimitra , Mavrogianni Despoina , Papamentzelopoulou Myrto , Stavros Sofoklis , Raouasnte Rami , Loutradis Dimitris , Drakakis Peter 
Published: July 2022

Abstract

Objectives
The present case-control study investigates whether TP53 Arg72Pro variant (rs1042522) serves as a risk factor for recurrent pregnancy loss (RPL) in Greek women.

Methods
The study group consisted of 100 patients with at least two miscarriages of unexplained etiology, before the 24th week of gestation. The control group included 106 women with no pregnancy loss history. DNA was extracted and genotyped using specific primers for PCR amplification of the Arg72 and Pro72 alleles. Sanger sequencing was used for the discrimination between heterozygotes and homozygotes for Arg72Pro variant.

Results
This is the first study demonstrating the statistically significant higher frequency of TP53 Arg72Pro variant in Greek RPL women compared to controls (38% vs. 6.6%; OR=8.6682, 95% CI: 3.6446–20.6160; p<0.0001). GC genotype (Arg/Pro) and CC genotype (Pro/Pro) were statistically more common in RPL patients than in controls (16% vs. 1.9%; p=0.0027, and 22 vs. 4.7%; p=0.0008, respectively). C allele frequency was statistically significant higher in RPL group than in controls (30.0 vs. 5.7%; p<0.0001). According to the inheritance mode analysis, the model that best fit the data was the dominant model (OR=8.67, 95% CI=3.64–20.62; p<0.0001).

Conclusions
The is the first study disclosing strong evidence that TP53 rs1042522 is significantly associated with a higher risk for recurrent pregnancy loss in Greek women following a dominant model, thus, serving as a genetic marker for identifying women at increased risk of recurrent miscarriages.
Narrative Time and Narrative Viewpoints in Films About Revolutionary History During the “Seventeen-Year Period” (1949–1966)
Authors: Lu Shaoyang 
Published: July 2022

Abstract
Film narratology focuses on narrative time and narrative viewpoints. In films about revolutionary history produced in China’s “Seventeen-year Period” (1949–1966), narrative time chiefly involved choice of time, sequencing, and time spans (deformation of time). The creators basically followed the temporal order, so those films seem neat and standardized, giving prominence to the key plots and components. The narrative viewpoint of the day was chiefly omniscient, or a combination of the limited and omniscient viewpoints. The creators chose to let the narrator hide behind the text, so as to strengthen the “visual illusion” and promote the plot development through the plot itself. This narrative technique was decided by the ideology of the times and its aesthetic orientation.
Design – a new way to look at old molecules
Authors: Spalvieri Davide , Mauviel Anne-Marine , Lambert Matthieu , Férey Nicolas , Sacquin-Mora Sophie , Chavent Matthieu , Baaden Marc 
Published: July 2022

AbstractWe discuss how design enriches molecular science, particularly structural biology and bioinformatics. We present two use cases, one in academic practice and the other to design for outreach. The first case targets the representation of ion channels and their dynamic properties. In the second, we document a transition process from a research environment to general-purpose designs. Several testimonials from practitioners are given. By describing the design process of abstracted shapes, exploded views of molecular structures, motion-averaged slices, 360-degree panoramic projections, and experiments with lit sphere shading, we document how designers help make scientific data accessible without betraying its meaning, and how a creative mind adds value over purely data-driven visualizations. A similar conclusion was drawn for public outreach, as we found that comic-book-style drawings are better suited for communicating science to a broad audience.
Initial-boundary value problem of fifth-order Korteweg-de Vries equation posed on half line with nonlinear boundary values
Authors: Zhao Xiangqing , Wang Chengqiang , Bao Jifeng 
Published: July 2022

Abstract
In this paper, we study the initial boundary problem of fifth-order Korteweg-de Vries equation with nonlinear boundary values. First, we establish a so-called sharp boundary trace regularity associated with the linearized fifth-order Korteweg-de Vries equation. Then, aided by the sharp boundary trace regularity, we verify that initial-boundary value problem of fifth-order Korteweg-de Vries equation with nonlinear boundary conditions is locally well-posed when initial and boundary values are properly chosen.
Momentum-Based Load Prescriptions: Applications to Jump Squat Training
Authors: Harry John R. , Krzyszkowski John , Harris Katie , Chowning Luke , Mackey Ethan , Bishop Chris , Barker Leland A. 
Published: July 2022

Abstract
Harry, JR, Krzyszkowski, J, Harris, K, Chowning, L, Mackey, E, Bishop, C, and Barker, LA. Momentum-based load prescriptions: Applications to jump squat training. J Strength Cond Res 36(9): 2657–2662, 2022—Velocity-based training is often applied to ballistic exercises, like the barbell jump squat, to improve vertical jump performance. However, determining the ideal training load based on velocity data remains difficult because load prescriptions tend to be limited to subjective velocity loss thresholds, velocity ranges, or both. Using data from jump squats performed with 0, 15, 30, 45, and 60% of the 1-repetition maximum squat, we explored subjective and objective methods to determine the ideal training load. Specifically, we explored takeoff velocity and a related metric only recently discussed in the literature, system momentum (i.e., takeoff velocity multiplied by the mass of the athlete-load system). At the group level, an ideal training load could not be revealed objectively using takeoff velocity. With individual subjects, the process remained challenging using takeoff velocity. Conversely, an ideal training load could be revealed easily and objectively using system momentum at the group average and individual subject levels. System momentum at takeoff is well-suited to assist practitioners seeking to identify appropriate training loads for jump squat training and potentially other ballistic exercises. We suggest a pivot from velocity to system momentum when seeking to objectively establish training loads for the jump squat and related exercises.
Assessing Eccentric Hamstring Strength Using the NordBord: Between-Session Reliability and Interlimb Asymmetries in Professional Soccer Players
Authors: Bishop Chris , Manuel Jack , Drury Ben , Beato Marco , Turner Anthony 
Published: July 2022

Abstract
Bishop, C, Manuel, J, Drury, B, Beato, M, and Turner, A. Assessing eccentric hamstring strength using the NordBord: between-session reliability and interlimb asymmetries in professional soccer players. J Strength Cond Res 36(9): 2552–2557, 2022—The aims of the current study were to (a) determine between-session reliability of peak force during the Nordic hamstring exercise (NHE) in professional soccer players during the preseason and (b) determine the subsequent magnitude and direction of peak force asymmetry from the NHE between all test sessions. The NHE was used as a weekly monitoring tool in 14 professional soccer players, throughout a 6-week pre-season period to record peak force from the NordBord device (in Newtons—N) across an average of 6 repetitions for the dominant and nondominant limbs. The first 2 weeks were used as familiarization sessions, with 4 data collection sessions thereafter. When considering relative reliability, intraclass correlation coefficients (ICCs) showed moderate levels of between-session reliability across the 4 weeks on both limbs (dominant = 0.54–0.73 and nondominant = 0.68–0.73) and for the sum total (0.69–0.73). For absolute reliability, both limbs showed coefficient of variation (CV) values <10% across all 4 weeks, with the exception of the dominant limb between sessions 1–2 (10.06%). When determining systematic bias, no meaningful changes were evident in peak force on either limb (g = −0.59 to 0.40) or for the magnitude of asymmetry (g = −0.24 to 0.35). However, when assessing consistency in the direction of asymmetry, levels of agreement ranged from 43 to 57% across the data collection period, indicating substantial variation in the superior performing limb from session to session. The findings from this study indicate that 2 familiarization sessions is enough to elicit reliable peak force data during the NHE in professional soccer players during preseason, despite a very small learning effect across the testing period.
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma
Authors: Wang Jing , Zhou Yan , Zhang Donghui , Zhao Weiyi , Lu Yishi , Liu Chaoqun , Lin Wandie , Zhang Yujie , Chen Kunling , Wang Hui , Zhao Liang 
Published: July 2022

AbstractCarnitine metabolism is thought to be negatively correlated with the progression of hepatocellular carcinoma (HCC) and the specific molecular mechanism is yet to be fully elucidated. Here, we report that little characterized cysteine‐rich protein 1 (CRIP1) is upregulated in HCC and associated with poor prognosis. Moreover, CRIP1 promoted HCC cancer stem‐like properties by downregulating carnitine energy metabolism. Mechanistically, CRIP1 interacted with BBOX1 and the E3 ligase STUB1, promoting BBOX1 ubiquitination and proteasomal degradation, and leading to the downregulation of carnitine. BBOX1 ubiquitination at lysine 240 is required for CRIP1‐mediated control of carnitine metabolism and cancer stem‐like properties. Further, our data showed that acetylcarnitine downregulation in CRIP1‐overexpressing cells decreased beta‐catenin acetylation and promoted nuclear accumulation of beta‐catenin, thus facilitating cancer stem‐like properties. Clinically, patients with higher CRIP1 protein levels had lower BBOX1 levels but higher nuclear beta‐catenin levels in HCC tissues. Together, our findings identify CRIP1 as novel upstream control factor for carnitine metabolism and cancer stem‐like properties, suggesting targeting of the CRIP1/BBOX1/β‐catenin axis as a promising strategy for HCC treatment.
Cholecalciferol supplementation effectively improved tertiary hyperparathyroidism, FGF23 resistance and lowered coronary calcification score: a prospective study
Authors: Hu Shu-Meng , Bai Yang-Juan , Li Ya-Mei , Tao Ye , Wang Xian-Ding , Lin Tao , Wang Lan-Lan , Shi Yun-Ying 
Published: July 2022

Introduction
Tertiary hyperparathyroidism (THPT) and vitamin D deficiency are commonly seen in kidney transplant recipients, which may result in persistently elevated fibroblast growth factor 23 (FGF23) level after transplantation and decreased graft survival. The aim of this study is to evaluate the effect of vitamin D supplementation on THPT, FGF23-alpha Klotho (KLA) axis and cardiovascular complications after transplantation.

Materials and methods
Two hundred nine kidney transplant recipients were included and further divided into treated and untreated groups depending on whether they received vitamin D supplementation. We tracked the state of THPT, bone metabolism and FGF23–KLA axis within 12 months posttransplant and explored the predictors and risk factors for intact FGF23 levels, KLA levels, THPT and cardiovascular complications in recipients.

Results
Vitamin D supplementation significantly improved FGF23 resistance, THPT and high bone turnover status, preserved better graft function and prevented coronary calcification in the treated group compared to the untreated group at month 12. The absence of vitamin D supplementation was an independent risk factor for THPT and a predictor for intact FGF23 and KLA levels at month 12. Age and vitamin D deficiency were independent risk factors for coronary calcification in recipients at month 12.

Conclusion
Vitamin D supplementation effectively improved THPT, FGF23 resistance and bone metabolism, preserved graft function and prevented coronary calcification after transplantation.
Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study
Authors: Vallejo Casas Juan Antonio , Sambo Marcel , López López Carlos , Durán-Poveda Manuel , Rodríguez-Villanueva García Julio , Santos Rita Joana , Llanos Marta , Navarro-González Elena , Aller Javier , Pubul Virginia , Guadalix Sonsoles , Crespo Guillermo , González Cintia , Zafón Carles , Navarro Miguel , Santamaría-Sandi Javier , Segura Ángel , Gajate Pablo , Gómez-Balaguer Marcelino , Valdivia Javier , Puig-Domingo Manel , Galofré Juan Carlos , Castelo Beatriz , Villanueva María José , Argüelles Iñaki , Orcajo-Rincón Lorenzo 
Published: July 2022

Background
Up to 30% of differentiated thyroid cancer (DTC) will develop advanced-stage disease (aDTC) with reduced overall survival (OS).

Objective
The aim of this study is to characterize initial diagnosis of aDTC, its therapeutic management, and prognosis in Spain and Portugal.

Methods
A multicentre, longitudinal, retrospective study of adult patients diagnosed with aDTC in the Iberian Peninsula was conducted between January 2007 and December 2012. Analyses of baseline characteristics and results of initial treatments, relapse- or progression-free survival ((RP)FS) from first DTC diagnosis, OS, and prognostic factors impacting the evolution of advanced disease were evaluated.

Results
Two hundred and thirteen patients (median age: 63 years; 57% female) were eligible from 23 hospitals. Advanced disease presented at first diagnosis (de novo aDTC) included 54% of patients, while 46% had relapsed from early disease (recurrent/progressive eDTC). At initial stage, most patients received surgery (98%) and/or radioiodine (RAI) (89%), with no differences seen between median OS (95% CI) (10.4 (7.3–15.3) years) and median disease-specific-survival (95% CI) (11.1 (8.7–16.2) years; log-rank test P = 0.4737). Age at diagnosis being <55 years was associated with a lower risk of death (Wald chi-square (Wc-s) P < 0.0001), while a poor response to RAI to a higher risk of death ((Wc-s) P < 0.05). In the eDTC cohort, median (RP)FS (95% CI) was of 1.7 (1.0–2.0) years after RAI, with R0/R1 surgeries being the only common significant favourable factor for longer (RP)FS and time to aDTC ((Wc-s) P < 0.05).

Conclusion
Identification of early treatment-dependent prognostic factors for an unfavourable course of advanced disease is possible. An intensified therapeutic attitude may reverse this trend and should be considered in poor-performing patients. Prospective studies are required to confirm these findings.
Аксіопсихологічне проєктування життєвих досягнень особистості: технологічний аспект
Authors: Hulias Inesa 
Published: July 2022

Анотація. Мета нашого наукового пошуку полягає у тому, щоб теоретично проаналізувати тех­нологічний аспект аксіопсихологічного проєктування життєвих досягнень особистості. Методи. У до­слідженні застосовано методи концептуально-порівняльного аналізу, зокрема теоретичний аналіз і син­тез положень монографічної літератури, систематизація наукових джерел, порівняння й узагальнення даних, абстрагування. Результати. У дослідженні проаналізовано технології аксіопсихологічного проєкту­вання життєвих досягнень особистості в розрізі українських наукових шкіл – соціально-конструкціо­ніст­ської і психолого-герменевтичної та напрямів – психолого-акмеологічного та культурно-історичного, й ок­ремих авторських напрацювань. Окреслено можливості кожної з технологій (і стратегій). Висновки. У кон­текс­ті досліджень соціально-конструкціоністської школи технології оптимізації життєвих до­ма­гань осо­бистості – семіотизація, наративізація і технологія цілепокладання сприяють структу­руванню і систе­матизації власного майбутнього з урахуванням бажаних життєвих сценаріїв, віку та докладених у перспективі зусиль задля реалізації життєвих проєктів. Розглянуті психотерапевтичні стратегії досяг­нення успіху спрямовані на формування реалістичності і самодостатності проєктів майбутнього, сприя­ють особистісному зростанню. У плані психокорекції деформованих життєвих домагань і ресоціа­лізації проблемної молоді ефективними є спеціальні психотехнології транзактного аналізу і гештальт­терапії, НЛП, які допомагають формувати продуктивну програму життєдіяльності особистості. Пред­ставники психолого-герменевтичної школи надають перевагу дискурсивним технологіям, спрямованим на забез­печення особистості можливістю керувати своїми ресурсами, інтерпретувати і трансформувати власне життя. У межах психолого-акмеологічного напряму з метою самопізнання і розвитку навичок викорис­тан­ня акмересурсів задля досягнення акме-цілі ефективним є проведення акмеологічного тренінгу. Резуль­тативність технології проєктування життєвого шляху в контексті досліджень культурно-історичного напряму полягає у тому, що: розвиває комунікативні здібності проєктанта; сприяє в освоєнні бажаних соціальних ролей; стимулює пошук нових життєвих стратегій досягнення поставленої мети тощо.