bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KETERAMPILAN PROSES SAINS SISWA MENGGUNAKAN PENDEKATAN CONTEXTUAL TEACHING AND LEARNING DENGAN MODEL DISCOVERY LEARNING PADA MATERI TATA SURYA
Authors: Nafsah Wilda Zakyatun , Muharrami Laila Khamsatul , Hadi Wiwin Puspita , Rosidi Irsad 
Published: June 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pendekatan Contextual Teaching And Learning dengan model Discovery Learning terhadap keterampilan proses sains siswa. Penelitian menggunakan desain quasi experimental dengan teknik non equivalent posttest only control group design. Penelitian dilaksanakan di SMPN 1 Sukodadi dengan populasi semua peserta didik kelas VII. Sampel yang digunakan 2 kelas yaitu kelas VII C sebagai kelas eksperimen dan kelas VII D sebagai kelas kontrol. Hasil penelitian yang dilakukan menunjukkan bahwa: (1) ada perbedaan keterampilan proses sains siswa setelah diterapkan pendekatan Contextual Teaching And Learning dengan model Discovery Learning yang dibuktikan dengan nilai signifikansi lebih kecil dari 0,05 (0,0000,05) (2) keterampilan proses sains siswa memperoleh rata-rata untuk aspek kompetensi sebesar 70 kriteria tinggi.
UJI KELAYAKAN MEDIA PEMBELAJARAN VIDEO STOP MOTION BERBASIS CERITA FABEL
Authors: Afifah Nur , Muharrami Laila Khamsatul , Wulandari Ana Yuniasti Retno , Hadi Wiwin Puspita 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui kelayakan media pembelajaran video stop motion berbasis cerita fabel. Jenis penelitian yang digunakan yakni penelitian pengembangan dengan model pengembangan Hannafin and Peck. Hasil penelitian dan analisis data menunjukkan bahwa video stop motion berbasis cerita fabel sangat layak digunakan jika ditinjau berdasarkan kelayakan materi dengan validitas sebesar 91,67% dan reliabilitas sebesar 90,78%, dan video stop motion berbasis cerita fabel sangat layak digunakan jika ditinjau berdasarkan kelayakan media dengan validitas sebesar 85,00% dan reliabilitas sebesar 88,57%. Berdasarkan hasil tersebut dapat disimpulkan bahwa video stop motion berbasis cerita fabel sangat layak digunakan dalam proses pembelajaran.
DESKRIPSI PEMAHAMAN SISWA BERDASARKAN TEORI APOS PADA POKOK BAHASAN SUHU DAN KALOR
Authors: Zahroh Fatimatuz , Hidayati Yunin , Qomaria Nur , Ahied Mochammad 
Published: June 2022

Penelitian bertujuan untuk mendeskripsikan dan mengetahui faktor kemampuan pemahaman siswa berdasarkan teori APOS pada pokok bahasan suhu dan kalor. Pengambilan sampel penelitian menggunakan teknik non-probability sampling yaitu purposive sampling. Subjek penelitian yaitu 21 siswa kelas VII-D SMP Negeri 278 Jakarta tahun ajaran 2019/2020. Jenis yaitu mixed methods dengan explanatory sequential mixed methods design. Hasil penelitian menunjukkan rata-rata hasil tes pemahaman siswa berdasarkan teori APOS adalah 53,33% siswa melalui tahap aksi, 33,33% siswa melalui tahap proses, 12,28% siswa melalui tahap objek, 2,85% siswa melalui tahap skema. Faktor yang mempengaruhi pemahaman siswa adalah pemahaman pada soal, cara menghitung perubahan satuan suhu, penggunaan tanda + (plus) dan – (minus) pada suhu, lupa pada rumus yang harus digunakan dan cara penyelesaiannya pada pemuaian, miskonsepsi pada kalor, tidak memahami mekanisme perubahan suhu dan hubungannya dengan kalor serta kurangnya pemahaman pada perubahan suhu, pemuaian dan kalor
Pengembangan Model Pembelajaran Project Based Learning Untuk Meningkatkan Kemampuan Geometri Anak Usia 5-6 Tahun
Authors: Hasni Uswatul , Amanda Rizki Surya 
Published: June 2022

Penelitian ini bertujuan untuk menganalisis kebutuhan anak umur 5-6 tahun untuk meningkatkan kemampuan mengenal geometri, menghasilkan model pembelajaran project based learning yang layak untuk pengenalan kemampuan geometri anak usia 5-6 tahun, mengungkapkan efektifitas model yang dihasilkan terhadap kemampuan geometri anak. Penelitian ini merupakan jenis penelitian research and development (RD) yang menggunakan model Borg Gall. Dalam penelitian ini, 220 anak dan 22 guru dari tujuh sekolah berpartisipasi. Wawancara, angket, dan observasi digunakan untuk memperoleh data. Deskriptif kualitatif, konversi data dan paired sample t-test digunakan dalam analisis data. Hasil penelitiannya ialah dibutuhkan model project based learning yang dilengkapi dengan materi indikator pencapaian dan kesiapan sekolah untuk meningkatkan kemampuan mengenal geometri anak. Model yang dihasilkan ialah pengembangan pada sintaks, sistem sosial, peran anak, dan sistem pendukung yang diperoleh melalui proses validasi dan uji coba lapangan. Keefektifan model terllihat dari hasil uji paired t-test anak dengan hasil signifikansi 0,005.
DPP3 expression promotes cell proliferation and migration in vitro and tumor growth in vivo that associates with poor prognosis of esophageal carcinoma
Authors: Liu Jing-Kun , Abudula Abulizi , Yang Hai-Tao , Xu Li-Xiu , Nuerrula Yiliyaer , Bai Ge , Tulahong Aisiker , Eli Maynur 
Published: June 2022

Abstract
Background
Dipeptidyl peptidase III (DPP3) is a zinc-dependent metallopeptidase and elevated in a variety of malignant tumors, but the underlying mechanism is not well understood so far. Here we investigated the association of esophageal carcinogenesis with the regulation of DPP3 expression by tissue-based quantitative analysis and the depletion of DPP3 expression in esophageal cancer cells and xenograft model.
Methods
The expression level of DPP3 in esophageal cancer tissues and adjacent normal tissues was detected in 93 cases of tissue biopsies collected from patients diagnosed with esophageal carcinoma by immunohistochemistry. The effect of DPP3 expression on cell proliferation, migration or apoptosis was determined in DPP3-depleted esophageal cancer cells created by infection with the lentivirus containing the shRNA specific to human DPP3 mRNA sequence followed by detection at the cellular level using celigo cell count assay, flow cytometry, wound-healing assay and trans-well assay as well as chip screening with a Human Apoptosis Antibody Array kit, which enables the quantitative detection of 43 apoptosis-related genes. A xenograft model was applied to the detection of tumor growth and invasion of DPP3-depleted cancer cells in nude mice.
Results
DPP3 expression was elevated in esophageal cancer tissues compared with adjacent non-tumor tissues (normal controls) with statistical significance (P < 0.05), and associated with poor prognosis of esophageal carcinoma. The DPP3-depletion resulted in a reduced cell proliferation and migration and enhanced cell-cycle arrest and apoptosis of esophageal cancer cells, and lead to the inhibition of tumor growth and invasion in xenograft model. In addition, DPP3-depletion was associated with the upregulation of pro-apoptotic proteins and the downregulation of anti-apoptotic proteins.
Conclusions
These findings suggest that DPP3 may promote cell proliferation, migration and survival of esophageal cancer cells in vitro, and tumor growth and invasion of esophageal carcinoma in vivo and this might serve as a molecular target for tumor therapy.
Examining theoretical lenses and methodological approaches to health research on/by/with Indigenous women in North America: A methodology for conducting a scoping review of the field
Authors: Loukes Keira A , Ferreira Celeste , Gaudet Janice Cindy , McGuire-Adams Tricia 
Published: June 2022

Abstract
Background: Indigenous women in North America experience multiple inequities in terms of health and well-being when compared to non-Indigenous women and Indigenous men. In an effort to understand these health disparities, there has been a surge of research in the field of Indigenous women’s health and well-being in the last 20 years. However, increasing research efforts will not necessarily benefit Indigenous women if that research is deficit-based and steeped in theoretical frameworks that perpetuate patriarchal colonial understandings of Indigenous women’s ill-health. We propose to create a theoretical framework tool to guide researchers in the field to conduct reciprocal, respectful, and regenerative research. Our first step in this project was to conduct a scoping review of the most current research in the field to determine which theoretical frameworks are being used, in which disciplines, and on which topics. This paper outlines the methodology of our scoping review. Methods: This scoping review follows an iterative six step process as laid out by Arksey and O’Malley (2005). We also followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (the PRISMA-ScR) as updated by Peters et al. (2020). Peer-reviewed, academic articles from the following databases were identified: Academic Search Complete, Native Health Database, Web of Science, Google Scholar, Bibliography of Native North America, Sociological Abstracts, Gender Watch, and Indigenous Peoples of North America. Two team members subsequently conducted two screens of titles and abstracts to include articles which focused exclusively on Indigenous women’s health and well- being, were published between 2011 and 2021, and explicitly stated their use of critical theory (i.e. Indigenous feminist, intersectionality, Indigenous resurgence, feminist, etc.) or community-based participatory research.Discussion: The results of our scoping review will map out the current field of Indigenous women’s health research. We will do this by identifying, categorizing, and analyzing research conducted from CBPR and critical theoretical lenses over the past decade. Our aim for the analysis will be to demonstrate the disciplines engaged in Indigenous women’s health and the ways in which theoretical lenses shape the research questions, methodologies, analysis, and implications of the research.
Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma
Authors: Liu Yu , Qian Yunzhen , Gong Yitao , Wang Ruijie , Dai Zhengjie , Zou Xuan , Tasiheng Yesiboli , Luo Guopei , Lin Xuan , Wang Xu , Yu Xianjun , Chen Yusheng , Cheng He , Liu Chen 
Published: June 2022

Abstract
BackgroundPancreatic ductal adenocarcinoma (PDAC) has a typical mucin expression pattern which is characterized as MUC1 positive, MUC2 negative and MUC5 positive. Mounting evidence has shown that mucins are involved in the development of pancreatic diseases. However, the correlation between mucin expression and prognosis of PDAC patients is controversial over the decades; thus, we aim to figure out the association of mucin expression with survival among PDAC patients who underwent radical resection.MethodsWe performed immunohistochemistry to detect the expression of MUC1, MUC2 and MUC5 in 427 resected PDAC specimens and got corresponding clinical statistics to conduct a retrospective study. Kaplan-Meier methods and Mantel-Cox tests were used to compare the survival curves, and Cox regression model was employed to make multivariate analyses and determine independent risk factors. The goat serum that we used purchase from Beijing Solarbio Science & Technology Co, item No: SL038-100ml.Ethical statementWe confirm that all methods were carried out in accordance with relevant guidelines and regulations in the Ethics approval and consent to participate section under Declarations in the manuscript.ResultsLog-rank tests demonstrated that MUC1 absence is significantly correlated with worse overall survival (OS) (p = 0.0079). MUC2 expression showed marginal significance in predicting shorter OS of PDAC patients (p = 0.055), while MUC5 did not show prognostic value. Besides, MUC1 absence is associated with increased proportion of stage III PDAC (p = 0.011). MUC1 absence and MUC2 expression are also associated with tumor perineural aggression (p = 0.011 and p = 0.030). Multivariable adjusted hazard ratio (HR) for mortality of MUC1 and MUC2 is 0.492 (95% CI: 0.274-0.883, p = 0.017) and 1.596 (95% CI: 1.061-2.401, p = 0.025) respectively.ConclusionsMUC1 negative expression or MUC2 positive expression is independently associated with poor overall survival among patients with resectable PDAC.
Expression Of CD44+/CD24-, RAD6 and DDB2 On Chemotherapy Response In Ovarian Cancer: A Prospective Flow Cytometry Study
Authors: Sihombing Unedo Hence Markus , Andrijono Andrijono , Purwoto Gatot , Gandamihardja Supriadi , Harahap Alida R. , Rustamadji Primariadewi , Kekalih Aria , Widyawati Retno , Fuady Dzicky Rifqi 
Published: June 2022

Abstract
Backgrounds: Ovarian cancer is the 8th deadliest common cancer in women around the world. Almost all ovarian cancer patients would experience chemoresistance, recurrence, and poor prognosis after cytoreductive surgery and platinum-based chemotherapy. Chemoresistant cancer cells have characteristic expressions of cancer stem cell proteins (CSCs) CD44+/CD24, RAD6 and DDB2. The increased expression of CD44+/CD24-, RAD6, and decreased DDB2 are believed to be associated with chemoresistance, recurrence, and poor prognosis of the disease. Thus, this study’s objective is to analyze the correlation between the expression of CD44+/CD24-, RAD6 and DDB2 with ovarian cancer chemoresistance. Materials and methods: This study was conducted with a prospective cohort of 64 patients who is divided into two groups (32 patients in each group) at the Obstetrics-gynecology and pathology department of Cipto Mangunkusumo, Tarakan, Dharmais, and Fatmawati Hospital. All suspected ovarian cancer patients underwent cytoreductive debulking and histopathological examination. Chemotherapy was given for six series followed by six months of observation. After the observation, we determined the therapy’s response with the RECIST Criteria (Response Criteria in Solid Tumors) and then classified the results into chemoresistant or chemosensitive groups. Flow cytometry blood tests were then performed to examine the expression of CD44+/CD24-, RAD6 and DDB2. Results: There was a significant relationship between increased levels of CD44+/CD24-, and RAD6 (p <0.05) levels with the chemoresistance of ovarian cancer. The logistic regression test showed that the CD44+/CD24‑ was better marker. Conclusions: These results indicate that CD44+/CD24 and RAD6 expressions are significantly associated with ovarian cancer chemoresistance, and CD44+/CD24- is the better marker to predict ovarian cancer chemoresistance.
Proof of Activity and Stake
Authors: Wang Xin , Wang Haojun , Chai Jianping , Li Jiawei 
Published: June 2022

Abstract
We proposed a decentralized cryptocurrency protocol named proof of activity and stake in which participants have no admittance threshold and communicate in peer-to-peer network. Our protocol adopts the idea of stakeholders in proof of stake and combined it with the propagation activity to replace the resource-costly proof of work. It is also proposed to solve the contradiction of security and throughput, which discouraged the promotion of blockchain applications. With analysis of security assurance and performance, proof of activity and stake is proved to be robust and economical against double spending attack.
Follicular fluid steroid levels and mitochondrial function from exosomes predict embryonic development
Authors: Yu Li , Liu Miao , Xu Shiji , Wang Zhenxin , Liu Te , Zhou Jiaye , Zhang Doudou , Dong Xi , Pan Baishen , Wang Beili , Liu Suying , Guo Wei 
Published: June 2022

Abstract
Purpose
Human follicular fluid (FF) is a complex biological fluid that contributes to the microenvironment of oocyte development. The aim of this study was to evaluate the role of steroid levels and mitochonrial function in embryo development during in vitro fertilization cycles.
Methods
This was a cohort study of 138 women receiving IVF/ICSI, including 136 FF samples from 109 infertile women. FF steroid levels were tested by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassays. The mRNA expression levels of mitochondrial electron transport chain (ETC) complex genes from FF exosomes were detected by qPCR.
Results
Analysis of these individual FF concentrations revealed that LH and FSH concentrations were higher in follicles in which the oocyte developed into a top quality (TQ) blastocyst (LH: 9.44 ± 2.32mIU/ml, FSH: 9.32 ± 1.01mIU/ml) than those in which there was a failure of fertilization (LH: 5.30 ± 0.84mIU/ml, FSH: 6.91 ± 0.62mIU/ml). In contrast, follicular cortisone concentrations were the lower for oocytes that resulted in a TQ blastocyst (12.20 ± 0.82mIU/ml). The receiver operating characteristic analysis showed that FF LH and FSH levels predicted TQ blastocyst with excellent AUC value of 0.711 and 0.747. Mitochondrial ETC complex I and III mRNA levels were increased in the FF exosomes of TQ blastocyst. Correlation analysis showed that mRNA levels of ETC complex I was positively correlated with LH and FSH levels in FF.
Conclusion
The levels of FF steroids from single follicle can predetermine subsequent embryo development to some extent. Furthermore, impaired exosome mitochondrial dysfunction is a potiential event that causes hormone change in embryo development.
Feasibility study of the southern extension land for the Mila town (North-East of Algeria) with a view to their urbanization: geotechnical and geophysical approach
Authors: Khoudir Khellaf , Bechkit Mohamed Amine , Chettah Wahid , Hadj Youcef Brahim El 
Published: June 2022

Abstract
This work presents the geotechnical and the geophysical characterizations of soil for an area forming the southeast extension of the Mila town (Marechau region). This area shows traces of ancient land movements, permanent flows, clayey lithology, and irregular morphology with a steep slope. To make decision for building it, we analyzed their soils by carrying out the core drilling tests, the dynamic penetration tests, the laboratory tests, the determination of the electrical resistivity in order to describe and to study the vertical and the lateral variability of the underlying geological formations, and measured the electrical resistivity to map the depth of bedrock roof. We also describe the three-dimensional organizations of underlying geological materials that make up the study area. The core drilling test results gave a clayey soil with limestone blocks. The dynamic penetration test shows two categories of soil. The laboratory tests confirm that the materials analyzed are clayey nature, saturated, very plastic, over-consolidated and medium to very compressible, with medium to strong swelling potential, and medium aggressiveness on concrete. The tomography results show a single layer land of a clayey nature with massive rocks embedded in it. The combination of these results with location, land morphology, tectonic and their sismotectonic aspect indicate that the area is at high-risk, and their urbanization requires rigorous and mandatory precautionary measures.
Using the Behaviour Centered Design to understand the facilitators and deterrents to hand hygiene among healthcare providers in the greater Kampala metropolitan area: Qualitative findings from a formative phase of a cluster-randomized trial
Authors: Ssekamatte Tonny , Mugambe Richard K. , Isunju John Bosco , Wanyenze Rhoda K. , Nalugya Aisha , Adyedo Christine , Wafula Solomon Tsebeni , Buregyeya Esther , Nuwemastiko Rebecca , Bateman Joann , Balen Julie , Lusenaka Lynnette , Yakubu Habib , Moe Christine L. 
Published: June 2022

Abstract
BackgroundHand hygiene is known to reduce healthcare-associated infections. However, it remains suboptimal among healthcare providers. In this study, we used the Behaviour Centered Design to explore the facilitators and deterrents of hand hygiene among healthcare providers in the greater Kampala Metropolitan area, Uganda.MethodsA formative qualitative study, enshrined in a cluster randomised trial was conducted in 19 healthcare facilities (HCFs). A total of 19 semi-structured and 18 key informant interviews were used to collect data on hand hygiene status, and facilitators and deterrents of hand hygiene. Data were transcribed verbatim and NVIVO 12.0 software was used to ease the analysis following a thematic framework.ResultsAbout 47.4% of the HCFs had sufficient hand hygiene infrastructure, and 57.9% did not report total compliance to hand hygiene during patient care. Constant reminders such as nudges, and frequency of patient contact and the nature of clinical work were the physical and biological deterrents respectively. Heavy workload in HCFs was the only biological deterrent. Executive brain facilitators included knowledge of workplace health risks and infection prevention and control (IPC) guidelines, and a positive attitude. A negative attitude was the executive brain deterrent to hand hygiene. Recognition and rewards and fear of infections were pointed out as the only motivated brain facilitators. Behavioural setting facilitators included proximity to functional hand hygiene infrastructure, the existence of active IPC committees, good leadership and availability of a budget for hand hygiene supplies. Behavioural setting deterrents included non-functionality and non-proximity to hand hygiene infrastructure and inadequate supplies.Conclusions Compliance to Hand hygiene practice and provisions was reported to be poor. Deterrents to hand hygiene included a heavy workload, negative attitude, inadequate supplies, non-functionality and long-distance to hand washing stations. Facilitators included constant reminders, fear of infections, frequency of patient contact and nature of clinical work, positive attitude, knowledge of IPC guidelines, recognition and reward, good leadership, availability of budgets for hand hygiene supplies, availability and proximity to hand hygiene supplies and infrastructure and active IPC committees. There is a need to remove the barriers and to maintain the facilitators to achieve optimal hand hygiene.ISRCTN Registry with number ISRCTN98148144. The trial was registered on 23/11/2020.
A Multi-Gateway Authentication and Key-Agreement Scheme on Wireless Sensor Networks for IoT
Authors: Yang Jen-Ho 
Published: June 2022

Abstract
In this paper, I propose a new multi-gateway authentication and key-agreement scheme on Wireless Sensor Networks (WSN) for Internet of Things (IoT). The proposed scheme provides a secure authentication and key-agreement method among different sensors, gateways, and users, so it can protect the data transmitted on WSN. Moreover, the proposed scheme adopts a new multi-gateway structure, and thus it allows users and sensors to join in different areas of WSN dynamically. Comparing with the related works, the proposed scheme can cover a wider area, and it can be applied to more IoT applications. Besides, the proposed scheme improves the security flows and reduces computation loads for the related works. Therefore, the proposed scheme is securer and more efficient than the related works on the WSN for IoT applications.
The Autocorrelation Distribution and 2-Adic complexity of a Class of Binary Generalized Cyclotomic Sequences with Period pq
Authors: Yan Wang , Liantao Yan , Heng Ziling , Zheng Xiuyun 
Published: June 2022

Abstract
A class of binary sequences with period pq is constructed using generalized cyclotomic classes, and their autocorrelation distribution and 2-adic complexity are determined using Gauss sum and group ring theory. The results show that the autocorrelation function of the new sequences is 3-level if p ≡ 3 (mod 4) and q ≡ 3 (mod 4) which is very close to the optimal and the 2-adic complexity of these sequences is maximum if p < q < 2p − 1. According to the rational approximation algorithm(RAA), these sequences have quite good cryptographic properties in the aspect of autocorrelation and 2-adic complexity.