bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not in the House?
Authors: Taylor James 
Published: February 2025

Abstract
Chapter 3 explores how the arrival of the female stockbroker in late Victorian Britain was regarded by the nation’s stock exchanges and by society in general. Though many responses were dismissive or flippant, there was an underlying nervousness, as women stockbrokers embodied several ideas—feminine financial competence, the prospect of financial independence, and freedom to pursue new careers—that challenged deep-seated prejudices. Longstanding fears about the defeminizing effects of involvement with finance were sharpened by fresh concerns about the ‘mannish’ and ‘masculine’ New Woman. The chapter shows the impact these responses had on women’s businesses, and the kind of image they sought to project. While they were able in many cases to form durable business links with men, the attitude of the stock exchanges themselves was hostile. The culture inside the stock exchanges became increasingly dominated by a particular type of masculinity—conformist, conservative, and competitive—which made women’s membership difficult to imagine. Though some supporters of women’s suffrage spoke in favour of women in finance, they often did so in ways that inadvertently entrenched the idea of stockbroking being essentially a masculine pursuit. These attitudes made it difficult—thought not entirely impossible—for women to succeed in finance in the long term.
Something in the City
Authors: Taylor James 
Published: February 2025

Abstract
Focusing on a cohort of eleven, Chapter 6 explores the shifting employment landscape for women stockbrokers after the Second World War. Women continued to be active in smaller provincial firms, but there was a significant expansion of opportunities at the bigger City firms. Stockbroking’s declining cachet among young men, attracted by careers in industry, forced brokerages to change traditional recruitment practices, and women graduates were well placed to take advantage. In addition, the shift towards professional examinations in the 1960s gave women a chance to prove their abilities, a ‘qualifications lever’ that opened stockbroking to more women than hitherto. These developments were matched by a partial ‘feminization’ of high finance, including banking and financial journalism. The chapter explores women’s professional identities, finding a dwindling involvement with women’s clubs and organizations, and a growing hostility to feminism. Women stockbrokers denied that their sex was relevant to their careers, an approach which celebrated finance as a meritocracy but which made it harder to challenge workplace cultures in which women continued to face dilemmas, difficulties, and pressures not experienced by most men.
A co-designed conceptual model for implementing falls prevention programmes for community-dwelling older adults in Singapore: a systems thinking approach
Authors: Koh Vanessa Jean Wen , Matchar David Bruce , Visaria Abhijit , Lai Wei Xuan , Goh Jing Wen , Poh Joann , Ginting Mimaika Luluina , Ho Vanda Wen Teng , Hosain Hozaidah , Ismail Noor Hafizah Binte , Lien Christopher , Lim Doris Yanshan , Merchant Reshma Aziz , Soh Shawn Leng Hsien , Chan Angelique Wei-Ming 
Published: February 2025

Abstract

Introduction
Implementing falls prevention programmes in the community presents numerous challenges. We sought to understand the dynamics between the determinants influencing implementation to develop a common conceptual model describing the complexities of implementing falls prevention programmes in Singapore.

Methods
A full-day group model building workshop with a series of structured activities was organised with 31 multidisciplinary stakeholders. Stakeholders who attended include healthcare professionals of different specialities (i.e. geriatrics, rehabilitation medicine, physiotherapy, nursing), community-based voluntary welfare organisations, researchers and policymakers.

Results
A causal loop diagram was developed to illustrate the determinants influencing implementation of community-based fall prevention programmes. It revealed factors driving key implementation and service outcomes in supply and demand of such programmes. Determinants of these outcomes were synthesised into four themes: (i) structural factors affecting the management and resource allocation for community-based falls prevention programmes, (ii) participation in programmes affected by older adults’ willingness and ability to participate, (iii) perceived value as a composite of costs and benefits, and (iv) social support and exercise self-efficacy motivating long-term adherence. Furthermore, in our analysis of feedback relationships, two organisational behaviours were identified: unsustainable growth due to resource constraints (Limits to Growth) and tensions between executing symptomatic or fundamental solutions (Eroding Goals). Stakeholders also explored strategies for effective implementation.

Conclusions
A conceptual model describing the dynamics of implementing community-based fall prevention programmes was developed. This informed the formulation of a National Falls Prevention Framework, a priority action step for the effective implementation of these programmes in Singapore.
A qualitative study regarding older people’s goals of care in relation to frailty status: finding meaning in ‘smaller things’ in life
Authors: van der Klei Veerle M G T H , van den Bos Frederiek , Mooijaart Simon P , Julien Anneke G , Maissan Mabel J E , van Raaij Bas F M , Festen Jan , Gussekloo Jacobijn , Drewes Yvonne M 
Published: February 2025

Abstract

Background
Increasingly frailty assessment is part of the shared decision-making process of older patients. However, little is known of the role of frailty in goals of care among the diverse group of older persons.

Objective
To explore the role of frailty in older people’s perspectives on goals of care in case of acute and/or severe disease.

Methods
We conducted semi-structured interviews with people aged ≥70 years in the Netherlands (n = 26), which were purposively sampled based on a self-reported Clinical Frailty Scale. The interviews were analysed using thematic content analysis to compare frailty subgroups.

Results
Three themes regarding goals of care emerged: (1) preserving well-being in one’s lifeworld through life goals; (2) goals related to care, as access to appropriate care, good contact with care professionals and a dignified end-of-life; (3) differences in attainment and adaptation of goals of care according to frailty status. The first two themes appeared to be independent of frailty status. However, differences were seen in theme 3, as fit older people primarily strengthened their capacity to attain goals of care, while frail older people primarily adapted the meaning ascribed to goals of care and had higher acceptance of the life cycle.

Conclusion
Goals of care that older people want to attain are driven by life goals, independent of frailty. Therefore, older people with varying frailty status could be treated similarly in goal-setting and life goals. However, different support may be needed for the attainment and adaptation of their goals of care.
The TIE-93: a Facial Emotion Recognition Test Adapted for Culturally, Linguistically, and Educationally Diverse Alzheimer’s Dementia Patients in France
Authors: Bourdage Renelle , Franzen Sanne , Palisson Juliette , Maillet Didier , Belin Catherine , Joly Charlotte , Papma Janne , Garcin Béatrice , Narme Pauline 
Published: February 2025

Abstract

Objective
Emotion recognition tests are essential for differential diagnostics when assessing patients with Alzheimer’s disease (AD) dementia. However, there remains a lack of emotion recognition tests appropriate for culturally and educationally diverse populations. The aim of this study was to develop an emotion recognition test (the TIE-93) appropriate for these populations. We then examined whether the TIE-93 could reduce emotion recognition performance differences between populations with a native French versus a culturally and educationally diverse background (participants who had immigrated to France). This was assessed by comparing performance between controls of each cultural group. We also assessed the effect of demographic variables on TIE-93 test performance and whether performance in an AD patient group was consistent with the research literature.

Methods
Fifty-seven patients with AD dementia and 240 healthy controls, from native French and culturally and educationally diverse backgrounds, were included in the study. The TIE-93 is composed of eight panels with photos of actors displaying six basic emotions. Participants were asked to identify which of the six facial expressions displayed matched an oral description of a context.

Results
When comparing French and culturally and educationally diverse controls, Quade’s ANCOVA revealed that there remained an effect of culture and education on TIE-93 test performance. Nonetheless, while controlling for years of education, age, sex, and cultural group, patients with AD dementia scored significantly more poorly than controls, specifically for most negative emotions.

Conclusion
The TIE-93 represents a first step toward developing appropriate emotion recognition tests for culturally and educationally diverse populations.
BADGER: Biologically-Aware Interpretable Differential Gene Expression Ranking Model
Authors: Kim Hajung , Gim Mogan , Baek Seungheun , Park Soyon , Kim Sunkyu , Kang Jaewoo 
Published: February 2025

Abstract
Understanding which genes are significantly affected by drugs is crucial for drug repurposing, as drugs targeting specific pathways in one disease might be effective in another with similar genetic profiles. By analyzing gene expression changes in cells before and after drug treatment, we can identify the genes most impacted by drugs. The Biologically-Aware Interpretable Differential Gene Expression Ranking (BADGER) model is an interpretable model designed to predict gene expression changes resulting from interactions between cancer cell lines and chemical compounds. The model enhances explainability through integration of prior knowledge about drug targets via pathway information, handles novel cancer cell lines through similarity-based embedding, and employs three attention blocks that mimic the cascading effects of chemical compounds. This model overcomes previous limitations of cell line range and explainability constraints in drug-cell response studies. The model demonstrates superior performance over baselines in both unseen cell and unseen pair split evaluations, showing robust prediction capabilities for untested drug-cell line combinations. This makes it particularly valuable for drug repurposing scenarios, especially in developing therapeutic plans for new or resistant diseases by leveraging similarities with other diseases.
‘Why on Earth Aren’t You Doing Anything?’: Private and Voluntary Policing of Nightlife in Norway
Authors: Foshaugen Marina Hiller 
Published: February 2025

Abstract
This paper explores the role of private security guards and volunteers from ‘The Night Ravens’, and their contribution to the policing of nightlife in Norway. One of their functions in this context is to ‘observe and report’ if they witness deviant, severe or illegal activity. However, the situations they encounter, and expectations associated with their role, may problematize this intended function. This paper analyses experiences and self-understandings of these actors’ practices and argues that conflicting norms affect their role when policing the nightlife. Through observations and interviews with bouncers and Night Raven volunteers, empirical data shows that their organizational mandate, the situations they encounter and relations to others poses different considerations that potentially create tension regarding their role and agency.
The AI Doctor Will See You Now: Public Perspectives on Artificial Intelligence in Healthcare
Authors: Horst Carolyn , Aniq Muhammad , Taylor-Gee Alice , Wong Jennifer , Goh Vicky 
Published: February 2025

Abstract

Objectives
The use of artificial intelligence (AI) in healthcare is a growing field of research and clinical application. The views of the general public, ie future healthcare users, need to be surveyed and interpreted so that researchers and the public have a shared understanding of the appropriate use of AI. Currently, there is only limited data on the public’s views.

Methods
An anonymous, quantitative questionnaire was administered as part of a public exhibition on AI. The questionnaire was based on previously validated questions designed to assess respondents’ views on the use of AI in healthcare. Brief demographic data were also collected.

Results
The population surveyed was more diverse and younger than the general UK population (65% white, 45% aged 18-29). Respondents were largely comfortable with the application of AI in healthcare: 80% felt positively about its use, 56% thought it would be safe. 70% did not feel that it would replace doctors, and most would not be happy for AI to make decisions without considering their feelings.

Conclusions
Our study shows that the population we surveyed, particularly young future healthcare users, are comfortable with the use of AI in healthcare, but do not see it as a replacement for doctors.

Advances in knowledge
This paper highlights views from the general public on the use of AI in healthcare, which is largely under researched.
Dithienobenzimidazole-Based Semiconducting Polymer for Nonfullerene Organic Photovoltaics
Authors: Mikie Tsubasa , Ono Shohei , Hada Momoka , Osaka Itaru 
Published: February 2025

Abstract
Creation of thiophene-fused building unit is pivotal for development of high-performance organic semiconductors for organic electronics. Herein we report the design and synthesis of dithienobenzimidazole (DTBI) as a novel building unit for semiconducting polymers. The absorption spectrum of the DTBI-based polymer POBI were red-shifted by 20–60 nm relative to that of the polymers based on related building units, owing to the enhanced quinoidal character of DTBI. Photovoltaic cells based on POBI paired with a benchmark nonfullerene acceptor Y6 provided a power conversion efficiency of up to 6.3%. The photovoltaic performance of the POBI:Y6 blend film was characterized in terms of its crystallinity, morphology, and charge carrier transport properties.
Developmental plasticity to pond drying has carryover costs on metamorph performance
Authors: Wu Nicholas C , Fuh Nien-Tse , Borzée Amaël , Wu Chi-Shiun , Kam Yeong-Choy , Chuang Ming-Feng 
Published: February 2025

Abstract
Increasing variable hydroperiods may leave ectotherms with complex life cycles more vulnerable to the impacts of environmental drying. While developmental plasticity may enable some species to escape drying ponds, this plasticity might result in trade-offs with performance and subsequent fitness in adults. Here, we used rice paddy frogs (Fejervarya limnocharis) to test how pond drying influences the developmental plasticity of tadpoles, and the resulting carryover effects on body size and jumping performance. We predicted that tadpoles under simulated drought conditions (2–0.25 cm depth) compared to low stable water level conditions (0.25 cm depth) would develop faster, and the resulting metamorphs would be smaller and exhibit lower jumping performance. We show that tadpoles in drying conditions had a faster developmental rate than tadpoles in stable low water level treatments. The size of metamorphs from the drying treatment was similar to the high-water treatments (2 cm depth), but maximum jumping distance of individuals from the drying condition was lower than that of the high-water treatment. These results indicate that drying conditions for F. limnocharis increase development rate without a reduction in size at metamorphosis, but with poorer mass-independent locomotor performance, which can potentially impact their survival.
Feasibility of coronary access after transcatheter aortic valve implantation (TAVI): a systematic review and metanalysis of observational studies
Authors: Giacobbe Federico , Morena Arianna , Bruno Francesco , Nebiolo Marco , De Filippo Ovidio , Odeh Yasser , Pietro Gianluca Di , Cabau Josep Rodes , Conrotto Federico , Kini Annapoorna , Giannino Giuseppe , Latib Azeem , Omedé Pierluigi , Noble Stephane , La Torre Michele William , Barbanti Marco , Tarantini Giuseppe , Kim Won-Keun , Blumenstein Johannes , Boukantar Madjid , Htun Wan Wan , de Ferrari Gaetano Maria , Salizzoni Stefano , D'Ascenzo Fabrizio 
Published: February 2025

Abstract

Introduction
The expanding indications for transcatheter aortic valve implatation (TAVI) to younger, lower-risk patients, entails assessing not only the short-term clinical outcomes but also the long-term considerations for future interventions. The prevalence of coronary artery disease (CAD) in TAVI patients is relevant, and the optimal timing of percutaneous coronary intervention (PCI) remains a question.

Methods
We conducted a systematic literature review and meta analysis including 20 eligible studies involving 1660 patients who underwent coronary angiography after TAVI. The primary endpoint was the incidence of successful selective coronary re-access. Secondary endpoints included semi-selective and non-selective access rates. The analysis was stratified by balloon-expandable (BEVs) and self-expandable valve (SEVs) types.

Results
Successful coronary access after TAVI was feasible in the majority of patients, with a higher success rate observed for the left main (LM) compared to the right coronary artery (RCA). BEVs demonstrated the highest success rates in coronary ostia cannulation, achieving nearly 100% success for both LM and RCA. Among SEVs, the Acurate Neo and Evolut R/PRO showed superior success rates in selective coronary access (68% and 77% for LM; 57% and 72% for RCA, respectively) compared to the CoreValve (46% for LM and 49% for RCA). Notably, the majority of coronary angiograms were performed due to acute coronary syndrome, primarily non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA).

Conclusions
Selective coronary engagement after TAVI is generally achievable, with BEVs demonstrating superior success rates compared to SEVs. Among SEVs, the Acurate NEO showed better outcomes than the other types.
May Measurement Month 2022: an analysis of blood pressure screening results from Armenia
Authors: Zelveian Parounak , Hakobyan Zoya , Gharibyan Heghine , Aroyan Siranush , Melkonyan Arevik , Hazarapetyan Lusine , Grigoryan Svetlana , Beaney Thomas , Kerr Gabriele , Poulter Neil R 
Published: February 2025

Abstract
The May Measurement Month (MMM) campaign was carried out in Armenia in 2022 with the aim of raising awareness of raised blood pressure (BP). Here, we report on the findings of the campaign.
Adults aged ≥18 years were recruited opportunistically in public areas, both indoor and outdoor, as well as in primary and secondary healthcare centers. Three seated BP readings were taken for each participant, along with completion of a questionnaire on demographics, lifestyle factors, and comorbidities. Hypertension was defined as a systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg or being on antihypertensive medication. Controlled BP was defined as being on antihypertensive medication with a BP &lt;140/90 mmHg. Multiple imputation was used to estimate any missing BP readings. In total, 11 618 participants were screened, with a mean age of 52.4 (SD 16.5) years and 55.7% of whom were female. Of all participants, 5999 (51.6%) had hypertension, of whom 3729 (62.2%) were aware, and 3203 (53.4%) were on antihypertensive medication. Of those on antihypertensive medication, 1130 (35.3%) had controlled BP, and of all participants with hypertension, only 18.8% had controlled BP. In total, 4869 (41.9%) were found to have either untreated or inadequately treated hypertension.
The MMM campaign in Armenia identified significant numbers of participants with either untreated or inadequately treated hypertensives. We found that the percentage of hypertensives who are not adequately treated is still substantial in Armenia, which is a vital contributor to the growing burden of non-communicable diseases. MMM is a pragmatic and reasonably inexpensive tool to improve public awareness of BP in the general population.
Social inequalities in the effects of school-based well-being interventions: a systematic review
Authors: Haataja Eetu , Leppä Heidi , Huhtiniemi Mikko , Nedelec Rozenn , Soini Tiina , Jaakkola Timo , Niemelä Mika , Tammelin Tuija , Kantomaa Marko 
Published: February 2025

Abstract

Rising public concern about comprehensive child and adolescent well-being has led to the development of school-based interventions with the potential for high-reaching and effective support. While some interventions have shown effectiveness, limited understanding exists regarding how social inequalities are considered and evidenced in such interventions. This study examines how social inequalities are considered in universal school-based interventions and their potential to affect inequalities through differential effects. A systematic review following the PRISMA protocol was conducted using the following databases: PubMed, Web of Science, CINAHL, Scopus, ProQuest and APA PsycArticles. Studies published between 2014 and 2023 were included. Screening and data extraction were conducted independently by two researchers. Of 10 028 initial articles, 44 were included in the final analysis. These studies primarily involved physical activity and mindfulness interventions in schools. Despite many studies including information regarding students’ social backgrounds, such as socioeconomic position and immigrant background, the analysis of differential intervention effects among demographic groups was limited and mostly based on sex. Most differential effect analyses showed no significant differences based on social background, and no clear differences were found based on intervention type. While some universal school-based interventions show promise in reducing social inequalities in students’ well-being, more empirical research is needed to explicitly target these questions. This review highlights the critical need for comprehensive intervention studies to consider and report relevant dimensions of social background and their interactions with intervention effects.

Trial registration
PROSPERO; registration no. CRD42023423448
Characterizing heterologous protein burden in Komagataella phaffii
Authors: Kastberg Louise La Barbera , Jacobsen Irene Hjorth , Özdemir Emre , Workman Christopher T , Jensen Michael Krogh , Förster Jochen 
Published: February 2025

Abstract
Yeast is a widely utilized chassis for heterologous protein production, with Komagataella phaffii well-established as a prominent non-conventional yeast in this field. Despite its widespread recognition, there remains considerable potential to further optimize these cell factories to meet high production demands in a cost-effective and sustainable manner. Understanding the cellular response to the challenges of heterologous protein production can equip genetic engineers with crucial knowledge to develop enhanced strategies for constructing more efficient cell factories. In this study, we explore the molecular response of various K. phaffii strains that produce either the human insulin precursor or Mambalgin-1, examining changes in transcription and changes in intra- and extracellular protein levels. Our findings provide valuable insights into the molecular mechanisms that regulate the behaviour of K. phaffii production strains under the stress of producing different heterologous proteins. We believe that these results will serve as a foundation for identifying new genetic targets to improve strain robustness and productivity. In conclusion, we present new cellular and molecular insights into the response of K. phaffii cell factories to the challenges of burdensome heterologous protein production and our findings point to different engineering strategies for improved cell factory performance.