bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using dynamic microsimulation to project cognitive function in the elderly population
Authors: Wei Yifan , Heun-Johnson Hanke , Tysinger Bryan 
Published: September 2022

Background
A long-term projection model based on nationally representative data and tracking disease progression across Alzheimer’s disease continuum is important for economics evaluation of Alzheimer’s disease and other dementias (ADOD) therapy.

Methods
The Health and Retirement Study (HRS) includes an adapted version of the Telephone Interview for Cognitive Status (TICS27) to evaluate respondents’ cognitive function. We developed an ordered probit transition model to predict future TICS27 score. This transition model is utilized in the Future Elderly Model (FEM), a dynamic microsimulation model of health and health-related economic outcomes for the US population. We validated the FEM TICS27 model using a five-fold cross validation approach, by comparing 10-year (2006–2016) simulated outcomes against observed HRS data.

Results
In aggregate, the distribution of TICS27 scores after ten years of FEM simulation matches the HRS. FEM’s assignment of cognitive/mortality status also matches those observed in HRS on the population level. At the individual level, the area under the receiver operating characteristic (AUROC) curve is 0.904 for prediction of dementia or dead with dementia in 10 years, the AUROC for predicting significant cognitive decline in two years for mild cognitive impairment patients is 0.722.

Conclusions
The FEM TICS27 model demonstrates its predictive accuracy for both two- and ten-year cognitive outcomes. Our cognition projection model is unique in its validation with an unbiased approach, resulting in a high-quality platform for assessing the burden of cognitive decline and translating the benefit of innovative therapies into long-term value to society.
Improved performance with automatic sound management 3 in the MED-EL SONNET 2 cochlear implant audio processor
Authors: Kurz Anja , Rak Kristen , Hagen Rudolf 
Published: September 2022

Objectives
The SONNET 2 audio processor features ambient noise reduction (ANR), transient-noise reduction (TNR), and adaptive intelligence (AI). The primary aim of this study was to evaluate if using these features improves speech perception in noise, subjective listening effort, and sound quality.

Design
In this prospective longitudinal study, twenty adult SONNET users were fitted with the SONNET 2 audio processor, configured either as a default SONNET (no ANR/TNR/AI), with mild ANR/TNR, with strong ANR/TNR, with mild AI, and with strong AI. Speech perception in noise was assessed in speech and stationary noise from the front (S0N0); speech, stationary noise, and transient noise from the front (S0N0T0); and speech from the front in spatially-distributed stationary noise (S0N±45N±135). Listening effort, subjective sound quality, and device/setup preference were assessed.

Results
In the S0N0 setup, speech perception in noise was significantly better with the SONNET 2 when using ANR/TNR in the mild setup than with the SONNET or the SONNET 2 in the default SONNET configuration. In the S0N±45N±135 setup, speech understanding was significantly better in all four SONNET 2 configurations than with the SONNET or the SONNET 2 in the default SONNET configuration (a 1.26–2.55 dB SRT80 benefit). Subjects tolerated consistently lower signal-to-noise values with the SONNET 2 configurations using ANR/TNR than with the default SONNET configuration in all listening effort categories. All SONNET 2 configurations using ANR/TNR were preferred and better rated in speech in stationary and/or transient noise compared to the default SONNET configuration. Sound quality and pleasantness were better in those SONNET 2 configurations. Subjects strongly preferred the SONNET 2 configurations over the SONNET configuration.

Conclusions
The new front-end features implemented in the SONNET 2 audio processor objectively improve speech perception in noise. Subjects preferred the SONNET 2, over the SONNET, in the presence of stationary and transient noise.
Beyond opioid prescribing: Evaluation of a substance use disorder curriculum for OBGYN residents
Authors: Martin Caitlin E. , Thakkar Bhushan , Cox Lauren , Johnson Elisabeth , Jones Hendrée E. , Connolly AnnaMarie 
Published: September 2022

Objective
Amidst the current opioid crisis, there is a need for better integration of substance use disorder screening and treatment across specialties. However, there is no consensus regarding how to best instruct OBGYN trainees in the clinical skills related to opioid and other substance use disorders (SUD). Study objectives were (1) to assess the effectiveness a SUD curriculum to improve self-reported competence among OBGYN residents and (2) to explore its effectiveness to improve attending evaluations of residents’ clinical skills as well as its feasibility and acceptability from the resident perspective.

Methods
A pilot 3-session curriculum was developed and adapted to SUD screening and treatment which included readings, didactics, and supervised outpatient clinical experiences for OBGYN post-graduate year 1 (PGY-1) residents rotating through an integrated OBGYN-SUD clinic. Eighteen residents completed pre and post clinical skills self-assessments (SUD screening, counseling, referring, Motivational Interviewing) using an adapted Zwisch Rating Scale (range 1–5). Scores were compared between time points using paired t-tests. Sub-samples also (a) were evaluated by the attending on three relevant Accreditation Council for Graduate Medical Education Milestones (ACGME) milestone sets using the web-based feedback program, myTIPreport (n = 10) and (b) completed a qualitative interview (n = 4).

Results
All PGY-1s (18/18) across three academic years completed the 3-session SUD curriculum. Clinical skill self-assessments improved significantly in all areas [SUD Screening (2.44 (0.98) vs 3.56 (0.62), p = <0.01); Counseling (1.81 (0.71) vs 3.56 (0.51), p = < .01; Referring (2.03 (0.74) vs 3.17 (0.71), p = < .01; Motivational Interviewing (1.94 (1.06) vs 3.33 (0.69), p = < .01)]. Milestone set levels assigned by attending evaluations (n = 10) also improved. Qualitative data (n = 4) revealed high acceptability; all curriculum components were viewed positively, and feedback was provided (e.g., desire for more patient exposures).

Conclusion
A pilot SUD curriculum tailored for OBGYN PGY-1 residents that goes beyond opioid prescribing to encompass SUD management is feasible, acceptable and likely effective at improving SUD core clinical skills.
Internal plication for spring confinement to lengthen intestine in a porcine model
Authors: Rafeeqi Talha A. , Thomas Anne-Laure , Salimi-Jazi Fereshteh , Diyaolu Modupeola , Dunn James C. Y. 
Published: September 2022

Background
Short bowel syndrome and its resultant nutritional deficiencies are the most common cause of intestinal failure. Significant intestinal lengthening using intraluminal springs is feasible in porcine models using an external plication technique. We hypothesize that an internal plication technique will yield significant intestinal lengthening, which may lead to future endoscopic spring placement.

Methods
Uncompressed springs measuring 7.5 cm with a diameter of 1.0 cm were compressed to 2.0 cm. A gelatin-encapsulated compressed nitinol spring was inserted into the jejunal lumen of juvenile pigs and held in place with endoluminal sutures just proximal and distal to the spring-containing segment. A control segment distal to the spring was marked. Pigs were euthanized on postoperative day 7. Spring and control segments were collected for analyses.

Results
There was an average lengthening by 72% of the spring segment compared to the control segment. Two out of 7 springs stayed within both sets of plications and doubled in length. Histology showed normal mucosal integrity of the spring segment and plicated areas with similar muscular thickness but increased crypt depth and villus length compared to the control segment.

Conclusion
Internal plication resulted in significant bowel lengthening. Five springs had slipped through proximal, distal or both sets of plications, resulting in less lengthening than those that remained fixed. A more consistent methodology for endoluminal suturing is needed to produce more lengthening.
Mean platelet volume and immature platelet fraction as predictors of early onset neonatal sepsis risk in neonates of 28-36 weeks gestational age
Authors: Septiane Indah , Kadi Fiva Aprilia , Yuniati Tetty , Surtiretna Nina , Primadi Aris 
Published: September 2022

Background Early onset neonatal sepsis is a potential life-threatening problem for preterm infant. Diagnosing early onset neonatal sepsis is challenging. Difficulties in establishing diagnosis might cause delay definitive treatment.
Objective To analyze for potential associations between early onset neonatal sepsis (EONS) risk and mean platelet volume (MPV) as well as immature platelet fraction (IPF) in neonates of 28-36 weeks gestational age.
Methods A prospective cohort study was conducted at Dr. Hasan Sadikin General Hospital, Bandung, West Java. Mean platelet volume (MPV) and IPF were evaluated in the first ?6 hours of life and during the 48-72 hours after the first examination. This examination was followed by observation for sepsis development. Double logistic regression analysis was used.
Results Of 115 subjects, 45 preterm infants (39.1%) developed early onset neonatal sepsis. The increase in both mean MPV and mean IPF were significantly different (P<0.05). Double logistic regression analysis revealed that an increase in mean MPV (ORadj=6.14; 95%CI 1.99 to 18.96; P=0.002) and mean IPF (ORadj=6.56; 95%CI 2.64 to 16.34; P<0.001) were significantly associated with increased risk of sepsis.
Conclusion The MPV and IPF increase are associated with greater incidence of EONS in preterm infants.
A comparison of objective and subjective measurements of non-nutritive sucking in preterm infants
Authors: Wahyuni Luh Karunia , Mangunatmadja Irawan , Kaban Risma Kerina , Rachmawati Elvie Zulka Kautzia , Harini Melinda , Laksmitasari Budiati , Geraldyne Agatha , Sangwidjojo Inez Ayuwibowo , Utami Dini Prima , Poernomo Victor Prasetyo , Sudjono Adrian Prasetya 
Published: September 2022

Background Of preterm infants born before 32 weeks of gestation, 40-70% have atypical and immature feeding skills, which could delay initiation of oral feeding. A formal objective measurement of non-nutritive sucking may increase the accuracy of determining the right time to initiate oral feeding, however, most hospital perinatology care units do not own a suction pressure measurement device to objectively measure non-nutritive sucking parameters.
Objective To compare objective and subjective non-nutritive sucking (NNS) based on sucking pressure, number of suctions per burst, and time between bursts.
Methods One hundred twenty preterm infants born at 28-34 weeks’ gestation were evaluated for objective and subjective NNS. Data were collected from August to November 2021 at five hospitals in Jakarta. Objective NNS was measured by a suction pressure measurement device, while subjective NNS was clinically examined. Number of suctions per burst, sucking pressure, and time between bursts were analysed by Spearman’s correlation test.
Results A positive and significant correlation between objective and subjective NNS was found in all parameters (P<0.001). The highest correlation was found in time between bursts (r=0.74; P<0.001), followed by number of suctions per burst (r=0.60; P<0.001), and sucking pressure (r=0.58; P<0.001).
Conclusion The correlation between objective and subjective NNS examination was moderate in preterm infants. Therefore, an objective NNS measurement is still required for optimizing the examination.
Adipsic diabetes insipidus after transsphenoidal surgery for suprasellar intraventricular
Authors: Astafyeva L.  I. , Badmaeva I. N. , Sidneva Yu. G. , Klochkova I. S. , Fomichev D. V. , Chernov I. V. , Kalinin P. L. 
Published: September 2022

Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/L), polyuria (up to 4 liters per day) and absence of thirst. Normalization of water-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperative period. After release from the hospital, the patient independently stopped desmopressin therapy and did not consume an adequate amount of fluid of the background of polyuria. This led to severe hypernatremia (155–160 mmol/L) and rough mental disorders.Patients with ADI need closely monitoring of medical condition and water-electrolyte parameters, appointment of fixed doses of desmopressin and adequate hydration.
Myokines in obese adolescents with aerobic exercise
Authors: Kasyanova Yu. V. , Vasyukova O. V. , Okorokov P. L. , Zuraeva Z. T. , Bezlepkina O. B. 
Published: September 2022

BACKGROUND: Myokines are synthesized by myocytes and released into the bloodstream in response to muscle fiber contraction. They have a positive effect on carbohydrate and lipid metabolism, muscle mass growth, osteogenesis, increase tissue sensitivity to insulin, counteract inflammation of adipose tissue. The study of their secretion in response to physical activity (FA) can help to personalize the therapy of obesity.AIM: to study the features of the secretion of myokines in children with constitutionally exogenous obesity during physical activity of different duration and intensity and to evaluate their relationship with the parameters of the body composition.MATERIALS AND METHODS: 26 children (10 boys and 16 girls) were included in the study 15 [13; 16] years old, SDS BMI: +2.91 [2.24; 3.29], with sexual development according to Tanner 4–5. Two groups of 13 people were formed by random distribution. Group I performed FA (walking on a treadmill under the control of heart rate) of different duration: 30 and 60 minutes at the same intensity (less than 3 metabolic equivalents (MET)). Group II — FA of different intensity: low — less than 3 METH and moderate — 3–6 METH with the same duration of 45 minutes. Commercial kits for enzyme immunoassay were used to determine the level of myokines. The assessment of the compositional composition of the body was carried out by bioimpedance analysis (analyzer In Body 770, South Korea) in the morning, on an empty stomach. Statistical processing was carried out using STATISTICA v.12.0 (StatSoftInc., USA). The results are presented in the form of median (Me) and quartiles (Q1; Q3) corresponding to 25 and 75 percentiles. The critical significance level (p) was assumed to be <0.05.RESULTS: moderate intensity FA leads to a maximum increase in the level of myokines: interleukin-6 (IL-6) by 215.7% and decorin by 34.3%, a decrease in the level of irisin by 16.5%. An hour-long low-intensity workout leads to a moderate increase in the level of IL-6 by 80.5%, to a decrease in the level of irisin by 31.1%. Myostatin increases equally both after 60-minute FA and after moderate intensity FA by 30.9% and 31.8%, respectively. Short low-intensity FA (lasting 30 minutes) it is not accompanied by a significant increase in the expression of myokines. The relationship between the amount of muscle (r=0.65), lean (r=0.62), fat-free mass (r=0.64) and the level of decorin after FA was noted. There was no statistically significant relationship between the parameters of the body composition and the levels of IL-6, myostatin, and irisin. There were no gender differences in both basal and stimulated myokine secretion.CONCLUSION: Moderate intensity FA and low intensity 60-minute FA are most effective for obese children. A 30-minute low-intensity FN is insufficient to increase the secretion of myokines by skeletal muscles.
RAFT polymerization-induced self-assembly of semifluorinated liquid-crystalline block copolymers
Authors: Yang Yongqi , Yuan Zhilong , Yan Youjun , Zhang Daixin , Luo Xin , Liu Guangyao 
Published: September 2022

Abstract
It is a major challenge to prepare commercially viable scale semifluorinated liquid-crystalline block copolymers (SEFL-BCPs) using solution processing techniques. The technology of selectively solvating one block in a suitable solvent to realize self-assembly provides a promising route for the preparation of core-corona block polymer materials with extensive potential applications. However, considerable limitations have been discovered after much practice. BCP assemblies often require a separate synthesis step and are performed at high dilution. Herein, a one-pot approach combining polymerization-induced and crystallization-driven self-assembly (PISA-CDSA) was used to obtain well-defined, precise compositions of SEFL-BCPs. It is first synthesized via reversible addition-fragmentation chain transfer ethanol dispersion polymerization between 1H,1H,2H,2H-heptadecafluorodecyl acrylate and poly(N,N-dimethylacrylamide) at a concentration up to 20% v/v. Various morphologies, including 1D fiber-like micelles, 2D lamellar structures, and fusion structures, were first observed via transmission electron microscopy. This scalable PISA-CDSA strategy is greatly expanding the morphology scope and applicability of the polymer liquid crystal materials science field.
Plea for a Simple But Radical Change in Scientific Publication: To Improve Openness, Reliability, and Reproducibility, Let’s Deposit and Validate Our Results before Writing Articles
Authors: Girault Jean-Antoine 
Published: September 2022

AbstractLimited reproducibility and validity are major sources of concern in biology and other fields of science. Their origins have been extensively described and include material variability, incomplete materials and methods report, results selection, defective experimental design, lack of power, inappropriate statistics, overinterpretation, and reluctance to publish negative results. Promoting complete and accurate communication of positive and negative results is a major objective. Multiple steps in this direction are taken, but they are not sufficient and the general construction of articles has not been questioned. I propose here a simple change with a potentially strong positive impact. First, when they complete a substantial coherent set of experiments, scientists deposit their positive or negative results in a database [“deposited results,” (DRs)], including detailed materials, methods, raw data, analysis, and processed results. The DRs are technically reviewed and validated as “validated DRs” (vDRs) or rejected until satisfactory. vDR databases are open (after an embargo period if requested by the authors) and can later be updated by them or others with replications or replication failures, providing a comprehensive active log of scientific data. Articles, in this proposal, are then built as they currently are, except they only include vDRs as strong and open building blocks. I argue that this approach would increase the transparency, reproducibility, and reliability of scientific publications and have additional advantages including accurate author credit, better material for evaluation, exhaustive scientific archiving, and increased openness of life science material.
Comparison of Hepatic Arterial Infusion Chemotherapy and Transarterial Chemoembolization for Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Authors: Liu Haonan , Qin Xiaobing , Jiang Hong , Sun Chenyu , Wu Meng , Xu Zhiyuan , Lu Tong , Ma Xiao , Han Zhengxiang 
Published: September 2022

Aims: To compare the efficacy, safety, and survival outcomes of hepatic arterial infusion chemotherapy (HAIC) versus transarterial chemoembolization (TACE) for the treatment of advanced hepatocellular carcinoma (HCC), a comprehensive meta-analysis was conducted.
Methods: MEDLINE, PubMed, Web of Science, Embase, and the Cochrane Central Register of Controlled Trials were searched from January 1966 to 20 February 2022, and relevant articles were retrieved. The literature search, quality assessment, and data extraction were conducted independently by two reviewers. The primary endpoints were objective response rate (ORR) and overall survival (OS), while the secondary endpoints were disease control rate (DCR), progression-free survival (PFS), and adverse events. The odd ratios (OR) and hazard ratios (HR) with 95% confidence intervals (95%CI) were pooled.
Results: Seven studies with a total of 989 patients were included in this meta-analysis. The pooled results showed that HAIC significantly improved ORR (OR=4.94, 95%CI: 3.47-7.05, p<0.001) and DCR (OR=2.97, 95%CI: 2.16-4.08, p<0.001). In addition, HCC patients who received HAIC had significantly longer PFS (HR=0.54, 95%CI: 0.45-0.65, p<0.001) and OS (HR=0.55, 95%CI: 0.46-0.66, p<0.001) than those who underwent TACE. Compared with TACE, HAIC showed a lower incidence for grade 3-4 adverse events (OR=0.52, 95%CI: 0.30-0.88, p<0.001).
Conclusions: HAIC may significantly improve survival benefits and exhibit higher local treatment responses with mild side effects in patients with advanced HCC compared to TACE.
Coordinated Multi-Language Translation of A Validated Symptom Questionnaire for Carbohydrate Intolerances: A Practical Structured Procedure
Authors: Sonyi Marc , Hammer Johann , Basilisco Guido , Belei Oana , Benninga Marc A , Bordin Dmitry S , Dumitrascu Dan , Hauser Bruno , Herszenyi Laszlo , Lopetuso Loris , Mion Francois , Mulak Agata , Nakov Radislav , Nakov Ventsislav , Tepes Bojan , Hammer Heinz Florian 
Published: September 2022

Background and Aims: Validated questionnaires help to minimize diagnostic bias, to standardize symptom assessment and to achieve comparability between studies and centers. In a recent European guideline the adult and the pediatric carbohydrate perception questionnaires (aCPQ and pCPQ), were recommended to be used for the diagnosis of carbohydrate intolerances in adult and pediatric patients. The implementation of this guideline into clinical practice makes availability of validated translations a necessity.
Methods: Clinical experts who recognized the need for these questionnaires to be available in their own language participated in the translation process. The tasks were assigned and a workflow following a predefined procedure based on recommendations of the Rome foundation was developed. The procedure had 5 phases: foundation, nomination, translation, revision, cognitive debriefing. Results: Within eight months the aCPQ was translated into Bulgarian, French, Hungarian, Italian, Polish, Romanian, Russian and Slovenian language and the pCPQ into Dutch, French and Romanian. This expands the population which can be served with the aCPQ from 160 million to over 500 million Europeans. The reach of pCPQ expanded from 92 million to 193 million Europeans.
Conclusions: We report the development and implementation of a centrally organized process of translation of validated questionnaires, following a predefined procedure based on recommendations of the Rome foundation. This structured procedure may aid future efforts to standardize and harmonize the translation of validated questionnaires.