bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel non-invasive tests for colorectal cancer screening – A cost-effectiveness analysis
Authors: Rui Mingjun , Wang Yingcheng , You Joyce HS. 
Published: February 2025

Abstract
Background: To compare cost-effectiveness of 3 novel non-invasive tests (multitarget stool RNA (mt-sRNA), multitarget stool DNA 2.0 (mt-sDNA 2.0), and cell-free DNA (cf-DNA)) with guideline-recommended tests for colorectal cancer (CRC) screening from payer’s perspective. Methods: Outcomes of a hypothetical cohort of 100,000 individuals aged 45-year-old with average CRC risk (no prior CRC diagnosis, adenomatous polyps, or other disorders associated with a high lifetime risk of CRC) in the US were simulated by a lifelong Markov model. Screening strategies included: Guideline-recommended strategies (colonoscopy, flexible sigmoidoscopy, computed tomographic colonography, fecal immunochemical test, high-sensitivity guaiac-based fecal occult blood testing, multitarget stool DNA), 3 novel non-invasive tests, and no screening. Scenario analyses on perfect (100%) and test-specific adherence (reported real-world adherence) were conducted. Outcomes included direct cost, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs). Results: All screening strategies (versus no screening) reduced CRC cases and deaths. In perfect adherence scenario, every-10-year colonoscopy was the preferred strategy (ICER=US$261/QALY). In test-specific adherence scenario, every-3-year mt-sRNA was the preferred cost-effective strategy (ICER=US$95,250/QALY). Testing cost, performance, adherence, and CRC prevalence, progression rate and utility were influential factors. Every-3-year mt-sRNA showed the highest probability (37.6%) to be cost-effective in test-specific adherence scenario at willingness-to-pay US$100,000/QALY. Conclusions: All strategies were cost-effective compared to no screening. Every-3-year mt-sRNA (preferred strategy in real-world adherence scenario) provides a cost-effective alternative when adherence to CRC screening or follow-up was not perfect in clinical practice. Impact: This is the first study to demonstrate cost-effectiveness of novel non-invasive tests versus all guideline-recommended CRC screening tests.
A utilização do termo clave rítmica em relação aos padrões percussivos brasileiros: (des)conexões musicais na América Latina
Authors: Leitão Rogério Ribeiro das Chagas 
Published: February 2025

In this text we propose the study and analysis of the application of the term rhythmic key within the context of percussion in Brazil. Our objective is to verify how effective and comprehensive the use of this concept represents in this particular case. We have noticed that within the universe of Brazilian percussion, whether in its artistic practices or in teaching-learning aspects, this nomenclature has been applied. We will use references from researchers who are attentive to musical productions in the Americas, especially in musical processes carried out from the African diaspora. We put this theme up for debate as evidence of the relevance of research into Brazilian rhythms and percussions in a broad way, trying to contemplate their diversity.
Variations in the Medical Device Authorization and Reimbursement Landscape: A Case Study of 2 Cardiovascular Devices Across 4 Countries
Authors: Williams Marta M. , Smith Nathan R. , Uyl-de Groot Carin A. , den Uil Corstiaan A. , Ross Joseph S. , Mohamed Mohamed O. , Mamas Mamas A. , Banerjee Amitava , Ko Dennis T. , Landon Bruce , Cram Peter 
Published: February 2025

BACKGROUND:
The authorization process and coverage/reimbursement mechanisms for medical devices play critical roles in device adoption and usage. However, international variation in these processes remains poorly characterized, especially with regard to data transparency and the effects of reimbursement on usage.

METHODS:
This study examined publicly available databases, governmental agency recommendations and policies, and press releases from the United States, Canada, the United Kingdom, and the Netherlands to compare the regulatory approval processes and coverage/reimbursement mechanisms for 2 novel cardiovascular devices introduced in the early and late 2000’s: the Watchman left atrial appendage occlusion device and the Impella percutaneous ventricular assist device. In addition to qualitative comparisons for each country, this study compared the date of the first regulatory review, time from submission to review completion, device approval date, agency approval requirements, number of review cycles, and necessity of postapproval studies as determined by the regulator, date of funding decision, final funding decision, and requirements for device reimbursement by relevant government payors.

RESULTS:
Authorization data were easily accessible for the United States and Canada but extremely limited for the United Kingdom and the Netherlands. Chronologically, authorization occurred ≈10 years earlier in Europe (United Kingdom and the Netherlands) than in North America (United States and Canada) for both devices. The United States was the only country where the principal public payor (Medicare) explicitly reimbursed both procedures. The United States was similarly notable for more rapid adoption and higher utilization of both devices than the other countries, with the Watchman implanted at 3.4 devices per 100 000 adults annually and Impella used in 7 to 8 procedures per 100 000 people annually. In contrast, uptake was far lower in Canada and Europe.

CONCLUSIONS:
This research provides insights into how differences among countries in authorization and reimbursement mechanisms may impact the adoption and usage of medical devices, and may inform future policies on these processes.
Nationwide, Pragmatic, Direct-to-Patient Primary Aldosteronism Testing Program
Authors: Brown Jenifer M. , Tsai Laura C. , Abel Eva E. , Ferrebus Arnaldo , Moore Anna E. , Niebuhr Yvonne M. , Bacare Bassil , Honzel Brooke , Milks Julia , Foote Kristen , Newman Andrew J. , Parksook Wasita W. , Vaidya Anand 
Published: February 2025

BACKGROUND:
Primary aldosteronism, an endocrinopathy present in ≥10% to 25% of patients with hypertension, confers excess cardiovascular risk that can be mitigated with aldosterone-directed therapy. However, only 2% of eligible patients undergo guideline-recommended screening. This study aimed to bypass clinical inertia and identify people with primary aldosteronism using pragmatic, direct-to-patient testing.

METHODS:
Hypertensive adults were recruited via online platforms and underwent virtual consent and local phlebotomy. Using a standardized diagnostic algorithm, laboratory results with interpretations were communicated to patients and primary care providers. Follow-up was ascertained at 6 to 12 months. The primary outcome was the frequency of a positive test for primary aldosteronism. Secondary outcomes included follow-up primary aldosteronism testing and implementation of aldosterone-targeted therapies.

RESULTS:
The study population (N=694) had a mean age of 63.3±11.3 years, was 52.2% female, and hailed from 41 US states. Overall, 25.4% had a positive test for primary aldosteronism. Sleep apnea, resistant hypertension, and hypokalemia were the most common testing indications, with 55.2% of participants having ≥2 indications. Over half of participants (57%) were already under endocrinology, cardiology, or nephrology care, yet had not been tested. In longitudinal follow-up of participants with a positive result, 25.5% had additional testing and 13.7% were started on aldosterone-targeted therapy (mineralocorticoid receptor antagonist or adrenalectomy).

CONCLUSIONS:
Pragmatic, direct-to-patient testing, and simplified results interpretation is a feasible, scalable method to increase primary aldosteronism diagnoses and implementation of aldosterone-targeted therapies. Given that new hypertension guidelines recommend primary aldosteronism screening in all hypertensive people, practical approaches to test, interpret, and implement results will be essential.
Cold-season precipitation trend in subtropical East Asia tied to shifting westerlies: Role of Tibetan Plateau
Authors: He Chao 
Published: February 2025

Abstract
Precipitation in late cold season (February to April) over subtropical East Asia (STEA) exhibits a negative trend from 1979 to present, primarily due to weakening ascent motion. This study investigates the mechanism of weakening ascent over STEA, and identified the poleward shifting westerlies as a key driver. On interannual timescale, a poleward shift of the westerlies leads to weakened southern branch westerlies (SBW) on the southern side of Tibetan Plateau (TP), which further leads to a weaker downstream southerly wind component over STEA, associated with a weaker ascent motion generated by isentropic upglide of the southerly flow. During the post-1979 epoch, the SBW shows a substantial weakening trend in late cold season as a regional manifestation of the planetary-scale poleward shifting westerlies, which suppresses the ascent motion over STEA and accounts for more than a half of the decreasing precipitation over STEA in late cold season. TP plays a key role in connecting SBW to the southerly flow and ascent motion over STEA in cold season, and the absence of weakening SBW also explains the absence of drying trend over STEA in early cold season. External forcing leads to a moderate poleward shift of planetary-scale westerlies in the entire cold season based on climate model simulations, but it cannot explain the seasonality and magnitude of the observed trend in SBW. Decadal-scale internal variability may have largely boosted the poleward shifting westerlies in late cold season but offset it in early cold season.
Triple Bottom Line Sustainability Analysis: Does Ability Replace Apathy?
Authors: Hou Dan , Khan Muhammad Kaleem , Zahid Rana Muhammad Ammar , Hussain Muhammad Jameel 
Published: February 2025

This study delves into the correlation existing between the managerial prowess of CEOs and the performance of sustainability initiatives, drawing insights from the upper echelon theory. Through a comprehensive triple-down analysis, we ascertain whether an augmentation in managerial capabilities expedites the adoption of practices promoting environmental, social and economic sustainability (recognized as the pillars of sustainability). Furthermore, the research delves into the impact of CEOs’ career horizons on the relationship between CEO’s managerial ability and sustainability performance. Employing a panel data methodology on a dataset encompassing Chinese publicly listed companies spanning the years 2010 to 2019, our findings reveal a positive influence of CEOs’ managerial competence on the overall sustainability endeavors of these firms. These outcomes maintain their robustness even after subjecting them to various alternative empirical examinations. The conclusions drawn from these findings substantiate the interconnection between managerial skill and sustainability performance, underscoring the discrete impacts on each facet of the sustainability pillars. The identification of the potential for fostering sustainability practices through the skillful dissemination of management skills stands as a pivotal inference with significant implications for practitioners in the field. JEL Classification: G34, M12, Q56.
The vasoconstrictor adenosine 5′-tetraphosphate is a danger signal that induces IL-1β
Authors: Bockstiegel Judith , Engelhardt Jonas , Schuchardt Mirjam , Tölle Markus , Weindl Günther 
Published: February 2025

Abstract

Background
The endogenous nucleotide adenosine 5′-tetraphosphate (Ap4) is a potent vasoconstrictor. Despite its structural similarity to the danger signal adenosine 5’-triphosphate (ATP), the immunomodulatory effects of Ap4 remain unclear.

Methods
Modulation of interleukin (IL)-1β secretion by Ap4 was studied in both immune cells lines (THP-1, U937) and primary immune cells. Genetic and pharmacological approaches were used to characterize signaling. Cytokine production was measured using ELISA and multiplex assays, while cell viability was determined by MTT and LDH assays. Calcium influx and YO-PRO-1 uptake were assessed via microplate assays and flow cytometry, respectively. RNA sequencing and Western blotting were performed to analyze global gene expression and protein levels.

Results
We demonstrate that Ap4 stimulates IL-1β release in primed immune cells without affecting the levels of other cytokines, suggesting specificity in its immunomodulatory actions. Mechanistically, Ap4-induced IL-1β release was partially modulated by the P2X7 receptor, a key mediator of inflammation. However, unlike canonical inflammasome activators, this process was independent of potassium efflux, the NLRP3 inflammasome, and caspase-1. Ap4 specifically increased LDH release in macrophages irrespective of priming. Furthermore, Ap4-mediated calcium influx, crucial for immune cell activation, predominantly occurred through P2Y receptors rather than P2X7 receptors. Transcriptomic analysis highlighted Ap4-induced upregulation of metallothioneins, implicating metal ion homeostasis in Ap4-mediated responses.

Conclusions
Collectively, our findings suggest Ap4 as a novel pro-inflammatory mediator capable of inducing IL-1β release in innate immune cells through distinct mechanisms from classical NLRP3 inflammasome activators, shedding light on its potential role in inflammatory diseases and vascular disorders.
CYFIP1 coordinate with RNMT to induce osteosarcoma cuproptosis via AURKAIP1 m7G modification
Authors: Lin Zili , Wu Ziyi , He Yizhe , Li Xiangyao , Luo Wei 
Published: February 2025

Abstract
Osteosarcoma (OS) presents challenges due to its genomic instability and complexity, necessitating investigation into its oncogenesis and progression mechanisms. Recent studies have implicated m7G, a post-transcriptional modification, in the development of various cancers. However, research on m7G modification in OS remains limited. This study aimed to explore the impact of m7G modification in OS, focusing on the role and mechanism of CYFIP1, a member of m7G cap binding complexes. Our findings demonstrated prominent anti-OS effects of CYFIP1 in vitro and vivo. Mechanistically, CYFIP1 collaborated with RNMT to induce the m7G methylation of AURKAIP1 mRNA, which resulted in the stability and the increasing translation of AURKAIP1 mRNA. AURKAIP1, a kind of mitochondrial small ribosomal subunit protein, exhibited increased expression, leading to the dysregulation of mitochondrial translation. This, in turn, caused an increase in the expression of FDX1, eventually triggering cuproptosis in OS cells and repressing OS occurrence and progression. In summary, our study identified the CYFIP1/RNMT/AURKAIP1/FDX1 axis as a potential therapeutic target for OS. These insights contribute to OS research and may guide the development of novel treatments for this challenging disease.
Collaborative Improvement of Structure Shape and Surface Integrity in Titanium Alloy Hole Burnishing
Authors: Liu Jiahui , Feng Pingfa , Wang Zibiao , Zhang Jianfu , Feng Feng , Zhang Xiangyu 
Published: February 2025

Abstract
In the aerospace field, hole burnishing enhancement plays an essential role in improving the service performance of load-bearing holes. To satisfy the assembly accuracy and strength requirements, the structure shape and surface integrity must be considered simultaneously during the enhancement process. The current manufacturing process of hole burnishing has a relatively weak balance between the structure shape and surface integrity; therefore, it is necessary to analyze the mechanism and optimize the parameters to improve the strengthening effect of the holes. In this study, a two-dimensional longitudinal simplified model for the hole burnishing process was established, and the reasons for the surface roughness improvement of the hole wall and material accumulation on the upper surface were analyzed. Experiments were conducted to determine the influence of the burnishing parameters on the structure shape (material accumulation, shape contour, and roundness) and surface integrity (surface roughness, residual stress, and surface hardness), based on the opposite requirements of improving the structure shape and surface integrity for the burnishing depth (BD). The results showed that with an increase in the BD, the structure shape deteriorated, whereas the surface integrity improved. Fatigue behavior verification experiments were conducted, and parameter selection schemes for the collaborative improvement of the structure shape and surface integrity were discussed. For the holes of titanium alloy TB6 (Ti-10V-2Fe-3Al), the fatigue life can be increased by 162% when the BD, spindle speed, and feed rate were 0.20 mm, 200 r/min, and 0.2 mm/r, respectively.
Cutting Force and State Identification in High-Speed Milling: a Semi-Analytical Multi-Dimensional Approach
Authors: Zhang Yu , Duan Xianyin , Zhu Kunpeng 
Published: February 2025

Abstract
High-speed milling (HSM) is advantageous for machining high-quality complex-structure surface components with various materials. Identifying and estimating cutting force signals for characterizing HSM is of high significance. However, considering the tool runout and size effects, many proposed models focus on the material and mechanical characteristics. This study presents a novel approach for predicting micromilling cutting forces using a semi-analytical multidimensional model that integrates experimental empirical data and a mechanical theoretical force model. A novel analytical optimization approach is provided to identify the cutting forces, classify the cutting states, and determine the tool runout using an adaptive algorithm that simplifies modeling and calculation. The instantaneous un-deformed chip thickness (IUCT) is determined from the trochoidal trajectories of each tool flute and optimized using the bisection method. Herein, the computational efficiency is improved, and the errors are clarified. The tool runout parameters are identified from the processed displacement signals and determined from the preprocessed vibration signals using an adaptive signal processing method. It is reliable and stable for determining tool runout and is an effective foundation for the force model. This approach is verified using HSM tests. Herein, the determination coefficients are stable above 0.9. It is convenient and efficient for achieving the key intermediate parameters (IUCT and tool runout), which can be generalized to various machining conditions and operations.
Understanding the Machining Process of Hierarchical Micro/Nanograting Structures Used for Optical Variable Device
Authors: Geng Yanquan , Zhu Wenhan , Zhang Xiaosong , Zhang Aoxiang , Yan Yongda , Cui Hailong , Xue Bo , Wang Jiqiang 
Published: February 2025

Abstract
Hierarchical micro/nanograting structures have attracted increasing attention owing to their significant applications in the fields of structural coloring, anti-counterfeiting, and decoration. Thus, the fabrication of hierarchical micro/nanograting structures is important for these applications. In this study, a strategy for machining hierarchical micro/nanograting structures is developed by controlling the tool movement trajectory. A coupling Euler-Lagrange finite element model is established to simulate the machining process. The effect of the machining methods on the nanograting formation is demonstrated, and a suitable machining method for reducing the cutting force is obtained. The height of the nanograting decreases with an increase in the tool edge radius. Furthermore, optical variable devices (OVDs) are machined using an array overlap machining approach. Coding schemes for the parallel column unit crossover and column unit in the groove crossover are designed to achieve high-quality machining of OVDs. The coloring of the logo of the Harbin Institute of Technology and the logo of the centennial anniversary of the Harbin Institute of Technology on the surface of metal samples, such as aluminum alloys, is realized. The findings of this study provide a method for the fabrication of hierarchical micro/nanograting structures that can be used to prepare OVDs.
The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host
Authors: Ray Allyson M. , Tehel Anja , Rasgon Jason L. , Paxton Robert J. , Grozinger Christina M. 
Published: February 2025

Abstract
Organisms respond to infectious agents through diverse immune strategies, and may need to cater a specific response to distinct pathogen challenges, such as various strains of a virus, to maximize fitness. Deformed wing virus (DWV) is one of the most damaging viruses of honey bees (Apis mellifera) across the globe, with variant DWV-B currently expanding at the expense of variant DWV-A. While previous research has characterized general host transcriptomic responses to viral exposure, host responses to different DWV strains have not been fully explored. Here, we performed experimental infections with the two dominant strains of DWV, A and B, as well as a mixed infection, and conducted transcriptomic analyses to compare differences in host molecular response to infection. We confirmed canonical anti-viral response to DWV infection, including upregulation of Toll pathway genes and the antimicrobial peptides abaecin and hymenoptaecin. Furthermore, our results suggest a potential role of aerobic glycolysis during viral infection in honey bees. DWV-A and mixed infections were associated with differential expression of a much larger number of host genes than infection with DWV-B. That DWV-B potentially elicits a reduced host immune response may provide a mechanistic explanation for its higher virulence and global emergence. Overall, this study provides the first evidence for strain-specific immune responses to DWV infection, and integrates these findings into the broader domain of insect immunity and host-pathogen dynamics.