bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relapses of idiopathic inflammatory myopathies after vaccination against COVID-19: a real-life multicenter Italian study
Authors: Conticini Edoardo , d’Alessandro Miriana , Grazzini Silvia , Fornaro Marco , Sabella Daniele , Lopalco Giuseppe , Giardina Federico , Colafrancesco Serena , Rizzo Chiara , Guggino Giuliana , Priori Roberta , Conti Fabrizio , Iannone Florenzo , Bargagli Elena , Cantarini Luca , Frediani Bruno 
Published: June 2022

AbstractSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination plays a crucial role as pivotal strategy to curb the coronavirus disease-19 (COVID-19) pandemic. The present study described the clinical status of patients affected by idiopathic inflammatory myopathies (IIM) after COVID-19 vaccination to assess the number of relapses. We included all patients affected by IIM and followed by Myositis Clinic, Rheumatology and Respiratory Diseases Units, Siena University Hospital, Bari University Hospital, Policlinico Umberto I, Sapienza University, Rome, and Policlinico Paolo Giaccone, Palermo. They underwent a telephone survey. A total of 119 IIM patients (median, IQR 58 (47–66) years; 32males; 50 dermatomyositis, 39 polymyositis and 30 anti-synthetase syndrome) were consecutively enrolled. Except four patients who refused the vaccination, 94 (81.7%) received Comirnaty, 16 (13.9%) Spikevax, 5 (4.4%) Vaxzevria. Seven (6.1%) patients had flare after vaccination. One of them had life-threatening systemic involvement and died two months after second dose of COVID-19 vaccination. From logistic regression analysis, Chi2-log ratio = 0.045,the variable that most influences the development of flare was the number of organs involved (p = 0.047). Sixty-eight patients received the third dose of COVID-19 vaccination: 51(75%) Comirnaty and 17 (25%) Moderna. No patients had flares after third dose. Our study represents the largest cohort of IIM patients in which the incidence of recurrence after anti-SARS-CoV-2 vaccine was assessed. In line with real-life data from other diseases, we found a clinical non-statistically significant risk of relapse in our patients, which occurred seldom, usually mild and in patients with a more severe and aggressive course of disease.
Targeted phenolic profile of radler beers by HPLC-ESI-MS/MS: the added value of hesperidin to beer antioxidants
Authors: Di Matteo Paola , Bortolami Martina , Di Virgilio Ludovica , Petrucci Rita 
Published: June 2022

AbstractThe well-known health beneficial properties of beer are mainly due to phenolic antioxidants. Citrus-flavored beers represent a growing side-market in the beer industry, sparingly investigated to date. The phenolic profile of commercial radler beers (R1, R2) was investigated to evaluate the impact of the lemon juice added to beer in the industrial production. Results were compared to those obtained for opportunely chosen commercial beer (B) and lemonade (L). The study was carried out by an HPLC-MS/MS with an electrospray ionization source in selected ion recording mode, analyzing in a single chromatographic run 26 compounds belonging to the different phenolic classes of hydroxybenzoic, hydroxycinnamic and caffeoylquinic acids, flavonoids and prenylflavonoids. Different phenolic profiles were found for R1 and R2, mainly ascribed to different malt/hop/recipe used for the beer. High to very high level of hesperidin were found in the radlers, so that a major impact on phenolic antioxidants of the radlers was due to the lemon. Similarly, a major impact of the lemon aromas was found, D-limonene being the dominant peak resulting from the GC-MS analysis of the volatile fraction of the radlers.
Graphical Abstract
Critical Reflection: The Importance of Case Reviews and Reflective Practice in Rape and Serious Sexual Offences Investigations
Authors: Norman Jenny , Fox Andy , Harding Richard , Majid Asmaa , Williams Emma , Davies Kari , Horvath Miranda A. H. 
Published: June 2022

AbstractUsing methods and data from Operation Soteria Bluestone in Avon and Somerset Constabulary in 2021, this paper proposes two key approaches to critical reflection that we suggest all police forces should be using in rape and serious sexual offences investigations: individual critical reflection throughout investigations using ‘Reflective Practice Points’ and regular ‘Case Reviews’. One of the main themes from the data examined is the cumulative impact rape and serious sexual offences investigations have on officers. Given the high case load and lack of staff to manage the work means officers default to a 'can do attitude', but this is often at the expense of the officers' wellbeing. Reflective practice points embed critical reflection in day-to-day investigations, whilst case reviews allow for routine identification of strengths and areas for improvement across the force, basic strategies which should already be familiar to policing. Fundamentally, they are tools which can be incorporated and normalised into policing that strives to embed critical reflection in its normal operation. Simultaneously implementing these two approaches will introduce processes to support staff wellbeing, learning, and development, which will in turn contribute to the improvement of rape and serious sexual offence investigations. Having a blend of regular, informal, and formal avenues for critical reflection is key in the early identification of the different stressors experienced throughout the investigation process of rape and serious sexual offences.
Impacts of Long‐Term Urbanization on Summer Rainfall Climatology in Yangtze River Delta Agglomeration of China
Authors: Han Longfei , Wang Luhan , Chen Huimin , Xu Youpeng , Sun Fengpeng , Reed Kyle , Deng Xiaojun , Li Wenkai 
Published: June 2022

AbstractIn this study, we investigated the urbanization‐induced summer rainfall changes in the Yangtze River Delta (YRD) by analyzing long‐term observations and numerical simulations. The observation‐based analysis showed that long‐term urbanization increased the region's summer rainfall, particularly through the intensification of heavy rainfall, which is noted as the urban rain island (URI) effect. A series of numerical sensitivity experiments with three historical land use and land cover scenarios (1990, 2000, and 2010) were designed to further understand the urbanization impacts on rainfall. The observed URI effect was well reproduced by the numerical simulations, and on average, urban expansion during 1990–2010 increased summer rainfall over urban areas by 51.91 mm. The URI effect slightly weakened in the late stage of urbanization (2000–2010) compared to the early stage (1990–2000). We conclude that the strengthening of precipitation‐inhibiting effects during the late period offset the precipitation‐enhancing effects, which led to the weakening of the URI effect.
Compound Wind and Precipitation Extremes Across the Indo‐Pacific: Climatology, Variability, and Drivers
Authors: Li Delei , Chen Yang , Messmer Martina , Zhu Yuchao , Feng Jianlong , Yin Baoshu , Bevacqua Emanuele 
Published: June 2022

AbstractCompound wind and precipitation extremes (CWPEs) can severely impact multiple sectors and regions, often causing critical infrastructure failure and fatalities, especially in the Indo‐Pacific region, which is a hotspot for CWPEs of various synoptic origins. Results show that the northwestern Pacific Ocean and its coasts have experienced the most frequent, strongest, and longest‐lasting CWPEs in summer in recent decades, which are induced by cyclones. Landfalling atmospheric rivers are one of the main drivers for frequent occurrences of CWPEs in central and western China and the northwestern Indo‐China Peninsula in both boreal summer and winter. The frequency of CWPEs over southern China exhibits significant decreasing trends in contrast to increasing trends in equatorial tropical areas. Moreover, the magnitude and pattern for the observed changes in the frequency of CWPEs result primarily from the variations in the dependence between univariate extremes, when evaluating the Indo‐Pacific as a whole.
Isotopic Records of Ancient Wildfires in C4 Grasses Preserved in the Sediment of the Ross Sea, Antarctica
Authors: Ren Peng , Luo Chunle , Zhang Hongmei , Cui Chao , Sun Shuwen , Song Hongying , Xu Liping , Rebesco Michele , De Santis Laura , Liu Yanguang , Wang Xuchen 
Published: June 2022

AbstractWe report carbon isotopic values in total organic carbon (TOC) and pyrogenic carbon (PyC) preserved in two sediment cores from the Ross Sea, Antarctica. The δ13C values of PyC ranged from −10.9‰ to −17.2‰, with distinct differences from the δ13C values of TOC (−24.1‰ to −26.1‰) in the sediments. The radiocarbon ages of PyC were 9,128 and 8,410 years old on average in the two cores but were thousands of years younger than the ages of TOC at the same core depth. These isotopic records provide strong evidence indicating that the PyC was produced from ancient wildfires predominantly in C4 vegetation and transported to Antarctica in the atmosphere. We suggest that ancient wildfires in predominantly C4 grasslands likely frequently occurred on a large scale and at a high intensity in the Southern Hemisphere during the last deglaciation to mid‐Holocene period of 14,800–4,200 years ago.
Deepening the Late Quaternary's Deep Ocean Carbon Mysteries
Authors: Farmer Jesse R. 
Published: June 2022

AbstractChanges to the carbon content of the deep ocean, the largest reservoir in the surficial carbon cycle, are capable of altering atmospheric carbon dioxide concentrations and thereby Earth's climate. While the role of the deep ocean's carbon inventory in the last ice age has been thoroughly investigated, comparatively little is known about whether the deep ocean contributed to the change in the pacing and intensity of ice ages around 1 million years ago during the Mid‐Pleistocene Transition (MPT). Qin et al. (2022, https://doi.org/10.1029/2021GL097121) provide new reconstructions of deep ocean carbonate ion saturation, a proxy for carbon content, from the deep Pacific Ocean across the MPT. Intriguingly, their results show that a reduction in deep Pacific carbonate ion saturation across the MPT occurred at different intervals from carbonate ion saturation decline in the deep Atlantic Ocean. These results suggest a more nuanced contribution of whole‐ocean carbon sequestration to the climate changes reconstructed across the MPT.
Water Level Modulation of Wave Transformation, Setup and Runup Over La Saline Fringing Reef
Authors: Bruch William , Cordier Emmanuel , Floc'h France , Pearson Stuart G. 
Published: June 2022

AbstractCoral reefs represent an efficient natural mechanical coastal defense against ocean waves. The focus of this study is La Saline fringing coral reef, located in the microtidal West of La Réunion Island in the Indian Ocean, frequently exposed to Southern Ocean swell and cyclonic events. The aim is to provide a better understanding of the reef's coastal defense characteristics for several Southern Ocean swell events. Pressure sensors were placed across the reef to measure water level fluctuations and to study wave transformation. A numerical model (XBeach surfbeat), validated using field observations, was used to deepen understanding of wave transformation, wave setup and runup. Field measurements and model outputs show that as gravity waves dissipate over the reef, and frequency‐dependent dissipation of infragravity waves by bottom‐friction occurs, the reef acts as a low‐pass filter. Wave‐induced setup is found to be the dominant hydrodynamic component. Setup and runup are each 98% and 79% driven by the offshore significant wave height, and 2% and 21% driven by the tide. The modulation of the water level by setup is the main contributor to runup in the fringing reef. At semidiurnal timescales, setup and runup are in antiphase with tidal variations as lower water levels result in higher gravity wave energy dissipation, setup and runup. Simple‐to‐use transfer functions relating incident wave characteristics to these hydrodynamic components are proposed. The effects of bottom friction and water level on the defensive capacity of the coral reef highlight future implications of structural damage and sea level rise.
Neonatal Staphylococcus Aureus Sepsis: a 20-year Western Australian experience
Authors: Shadbolt Rachel , We Michael Lee Shee , Kohan Rolland , Porter Michelle , Athalye-Jape Gayatri , Nathan Elizabeth , Shrestha Damber , Strunk Tobias 
Published: June 2022

Abstract
Objectives
The purpose of this study was to characterise neonatal Staphylococcus aureus (SA) sepsis in Western Australia (WA) between 2001 and 2020 at the sole tertiary neonatal intensive care unit (NICU), examine risk factors for sepsis in the cohort, and compare short- and long-term outcomes to control infants without any sepsis.

Methods
Retrospective cohort study at the Neonatal Directorate at King Edward Memorial Hospital (KEMH) and Perth Children’s Hospital, using electronic databases and patient medical records.

Results
The overall incidence of SA sepsis was 0.10 per 1000 live births (62/614207). From 2001 to 2010 the incidence was 0.13/1000 live births, reducing to 0.07/1000 live births from 2011 to 2020. SA was most frequently isolated from endotracheal aspirates, and infants with SA sepsis had longer median duration of ventilatory support than those without any sepsis (31 days vs 18 days respectively, p < 0.001). In our cohort, SA sepsis was associated with worse neurodevelopmental outcomes compared to infants without any sepsis.

Conclusions
The incidence of neonatal SA sepsis has reduced over the last 20 years, suggesting potential effectiveness of the preventative interventions implemented. Endotracheal tube (ETT) colonisation and prolonged ventilation may be under-recognised as potential sources of SA infection. Our study suggests SA sepsis may negatively impact neurodevelopmental outcomes.
GaiaData Release 3
Authors: Ripepi V. , Clementini G. , Molinaro R. , Leccia S. , Plachy E. , Molnár L. , Rimoldini L. , Musella I. , Marconi M. , Garofalo A. , Audard M. , Holl B. , Evans D. W. , Jevardat de Fombelle G. , Lecoeur-Taibi I. , Marchal O. , Mowlavi N. , Muraveva T. , Nienartowicz K. , Sartoretti P. , Szabados L. , Eyer L. 
Published: June 2022

Context.Cepheids are pulsating stars that play a crucial role in several astrophysical contexts. Among the different types, the Classical Cepheids are fundamental tools for the calibration of the extragalactic distance ladder. They are also powerful stellar population tracers in the context of Galactic studies. TheGaiaThird Data Release (DR3) publishes improved data on Cepheids collected during the initial 34 months of operations.Aims.We present theGaiaDR3 catalogue of Cepheids of all types, obtained through the analysis carried out with the Specific Object Study (SOS) Cep&RRL pipeline.Methods.We discuss the procedures adopted to clean the Cepheid sample from spurious objects, to validate the results, and to re-classify sources with an incorrect outcome from the SOS Cep&RRL pipeline.Results.TheGaiaDR3 includes multi-band time-series photometry and characterisation by the SOS Cep&RRL pipeline for a sample of 15 006 Cepheids of all types. The sample includes 4663, 4616, 321, and 185 pulsators, distributed in the Large and Small Magellanic Cloud, Messier 31, and Messier 33, respectively, as well as 5221 objects in the remaining All Sky subregion which includes stars in the Milky Way field and clusters and in a number of small satellites of our Galaxy. Among this sample, 327 objects were known as variable stars in the literature but with a different classification, while, to the best of our knowledge, 474 stars have not been reported as variable before now and therefore they likely are new Cepheids discovered byGaia.
Sufficient conditions for graphs with {P2, P5}-factors
Authors: Dai Guowei , Hang Yicheng , Zhang Xiaoyan , Zhang Zan-Bo , Wang Wenqi 
Published: June 2022

For a graph G, a spanning subgraph F of G is called an {P2, P5}-factor if every component of F is isomorphic to P2 or P5, where Pk denotes the path of order k. It was proved by Egawa and Furuya that if G satisfies 3c1 (G − S) + 2c3 (G − S) ≤ 4|S| + 1 for all S ⊆ V(G), then G has a {P2, P5}-factor, where ck (G − S) denotes the number of components of G − S with order k. By this result, we give some other sufficient conditions for a graph to have a {P2, P5}-factor by various graphic parameters such as toughness, binding number, degree sums, etc. Moreover, we obtain some regular graphs and some K(1,r)-free graphs having {P2, P5}-factors.
The Association between Glycosylated Hemoglobin Level and Platelets Reactivity in Patients with Diabetes Mellitus Undergoing Elective Coronary Artery Bypass Grafting
Authors: Mihaljevic Martina Zrno , Petricevic Mate , Konosic Sanja , Svetina Lucija , Urlic Marjan , Starcevic Zrinka , Krzelj Kristina , Milosevic Milan , Kalamar Viktor , Gasparovic Hrvoje , Biocina Bojan 
Published: June 2022

Abstract
Background Diabetic patients tend to have increased platelet reactivity after coronary artery bypass grafting (CABG). The aim of this study was to determine the association between hemoglobin A1c (HbA1c) values and platelet reactivity and to evaluate the consequent impact on clinical outcomes in patients undergoing CABG.
Methods This prospective observational trial consecutively enrolled 225 diabetic patients undergoing CABG, between February 2014 and October 2018. HbA1c levels and platelet function (multiple electrode aggregometry [MEA]) were analyzed the day before surgery and on postoperative day 4 (POD 4). Patients were divided into two groups according to the HbA1c value: HBA1c < 7% and HbA1c ≥ 7%.
Results Significantly higher postoperative ASPI (platelet function test based on arachidonic acid) and ADP (platelet function test based on adenosine diphosphate) test values were observed at POD 4 compared with preoperative values (ASPI test: p < 0.001; ADP test: p < 0.001). The prevalence of preoperative aspirin resistance (AR) was 46.4% relative to 57.2% after surgery showing consistent increase in postoperative AR by approximately 10%. In addition, the prevalence of AR in the HbA1c < 7% group was higher by 10% compared with the HbA1c ≥ 7% group, both before and after surgery. We did not demonstrate differences in clinical outcomes between the HbA1c groups.
Conclusion Perioperative assessment of platelet reactivity in diabetic patients detects those with AR who may be at increased risk of adverse ischemic events. A personalized approach guided by MEA and administration of early and more potent antiaggregation therapy after CABG can be beneficial in this group of patients.
Long-Term Results after Fallot Repair
Authors: Kleinöder Jonas Markus , Purbojo Ariawan , Blumauer Robert , Cuomo Michela , Alkassar Muhannad , Dittrich Sven , Cesnjevar Robert 
Published: June 2022

Abstract
Background The aim of this study was to evaluate the long-term outcome and freedom from pulmonary valve replacement (PVR) after initial repair of tetralogy of Fallot (TOF).
Patients and Methods The cohort of 306 patients treated between 1980 and 2017 was divided into anatomical subgroups according to the diagnosis of TOF-pulmonary stenosis, TOF-pulmonary atresia and TOF-double outlet right ventricle. Patients were treated with transannular patch (TAP), valve sparing repair (VSR), or conduits from the right ventricle to the pulmonary arteries (RVPA conduits).
Results There were 21 deaths (6.9%), 14 being hospital deaths (4.6%) after primary correction and four deaths (1.3%) occurred after PVR. One patient died after a non-cardiac operation (0.3%). There were two late deaths (0.7%). During the past 12 years no early mortality has been observed. Ninety-one patients (30.4%) received PVR after a median of 12.1 ± 7.0 years with an early mortality of 4.4% (n = 4) and no late mortality. A significant difference in freedom from reoperation after TAP, VSR, and RVPA-conduits could be identified. Multivariate analysis displayed transannular repair (p = 0.016), primary palliation (p <0.001), the presence of major aortopulmonary collateral arteries (MAPCA; p = 0.023), and pulmonary valve Z-scores < − 4.0 (p = 0.040) as significant risk factors for PVR.
Conclusion TOF repair has a beneficial long-term prognosis with low morbidity and mortality. Pulmonary valve Z-scores < − 4.0, transannular repair, and presence of MAPCAs are associated with earlier PVR. Non-VSRs and TOF-pulmonary atresia lead to earlier reoperation but have no negative impact on survival.
A genome-wide association study (GWAS) identifies multiple loci linked with the natural variation for Al
Authors: Du Hanmei , Raman Harsh , Kawasaki Akitomo , Perera Geetha , Diffey Simon , Snowdon Rod , Raman Rosy , Ryan Peter R. 
Published: June 2022

Acid soils limit yields of many important crops including canola (Brassica napus), Australia’s third largest crop. Aluminium (Al3+) stress is the main cause of this limitation primarily because the toxic Al3+ present inhibits root growth. Breeding programmes do not target acid-soil tolerance in B. napus because genetic variation and convincing quantitative trait loci have not been reported. We conducted a genome-wide association study (GWAS) using the BnASSYST diversity panel of B. napus genotyped with 35 729 high-quality DArTseq markers. We screened 352 B. napus accessions in hydroponics with and without a toxic concentration of AlCl3 (12 μM, pH 4.3) for 12 days and measured shoot biomass, root biomass, and root length. By accounting for both population structure and kinship matrices, five significant quantitative trait loci for different measures of resistance were identified using incremental Al3+ resistance indices. Within these quantitative trait locus regions of B. napus, 40 Arabidopsis thaliana gene orthologues were identified, including some previously linked with Al3+ resistance. GWAS analysis indicated that multiple genes are responsible for the natural variation in Al3+ resistance in B. napus. The results provide new genetic resources and markers to enhance that Al3+ resistance of B. napus germplasm via genomic and marker-assisted selection.
Virus finding tools: current solutions and limitations
Authors: Privitera Grete Francesca , Alaimo Salvatore , Ferro Alfredo , Pulvirenti Alfredo 
Published: June 2022

Abstract

Motivation
The study of the Human Virome remains challenging nowadays. Viral metagenomics, through high-throughput sequencing data, is the best choice for virus discovery. The metagenomics approach is culture-independent and sequence-independent, helping search for either known or novel viruses. Though it is estimated that more than 40% of the viruses found in metagenomics analysis are not recognizable, we decided to analyze several tools to identify and discover viruses in RNA-seq samples.

Results
We have analyzed eight Virus Tools for the identification of viruses in RNA-seq data. These tools were compared using a synthetic dataset of 30 viruses and a real one. Our analysis shows that no tool succeeds in recognizing all the viruses in the datasets. So we can conclude that each of these tools has pros and cons, and their choice depends on the application domain.

Availability
Synthetic data used through the review and raw results of their analysis can be found at https://zenodo.org/record/6426147. FASTQ files of real data can be found in GEO (https://www.ncbi.nlm.nih.gov/gds) or ENA (https://www.ebi.ac.uk/ena/browser/home). Raw results of their analysis can be downloaded from https://zenodo.org/record/6425917.