bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Kandungan Logam Berat Pada Krim Pemutih di Kota Banjarmasin
Authors: Kusuma I Ketut Gunawan , Hidayah Nur , Alawiyah Tuti 
Published: December 2022

Latar Belakang: : Krim pemutih merupakan campuran bahan kimia atau bahan lainnya yang memiliki kemampuan memutihkan kulit. Keberadaan logam berat seperti Hg dan Cd yang terkandung dalam sediaan krim pemutih tentu sangat berbahaya, karena jika ion-ion logam berat tersebut terabsorbsi ke dalam jaringan atau organ tubuh, maka dapat berpotensi menimbulkan gangguan kesehatan
Tujuan: Penelitian ini bertujuan untuk mengetahui kandungan dan kadar logam berat merkuri dan kadmium pada sampel produk krim pemutih di Kota Banjarmasin, serta untuk mengetahui kadar logam berat merkuri dan kadmium apakah melebihi batas ketentuan BPOM RI NO 12 TAHUN 2019.
Metode: Penelitian menggunakan observasional analitic Rancangan Cross sectional. Sampel krim pemutih yang digunakan adalah produk krim pemutih yang tidak memiliki izin edar BPOM. Sebanyak lima sampel krim pemutih yang dibeli secara acak di tiga pasar yang ada di kota Banjarmasin dianalisis menggunakan spektrofotometri serapan atom.
Hasil: Hasil penelitian menunjukan kadar logam Hg tertinggi terlihat pada sampel krim pemutih dengan kode E 0,675 µg/kg, kandungan logam Cd tertinggi terlihat pada sampel krim pemutih dengan kode C 0,994 mg/kg.
Simpulan: Hasil tersebut berada di bawah batas ketentuan yang ditetapkan oleh BPOM RI NO 12 TAHUN 2019.
Kata Kunci: Krim Pemutih, Logam Berat, Spektrofotometri Serapan Atom.
Analisis Rhodamin B Dalam Lipstick Di Kecamatan Banjarmasin Utara
Authors: Tangkas Hansel Hens , Putri Trias S. , Aisyah Syarifah S. , Hairunnisa Hairunnisa , Oktavia Helda , Purnamasari Indah , Salbiah Siti , Rahmadani Rahmadani 
Published: December 2022

Latar Belakang: Rhodamin B merupakan zat warna sintesis yang umumnya digunakan sebagai zat warna kertas, tekstil atau tinta yang menyebabkan iritasi pada saluran pernapasan dan bila digunakan dapat menyebabkan terjadinya kanker dan kerusakan hati dalam tubuh. Penggunaan Rhodamin B pada waktu yang lama akan terjadi bahaya akut jika tertelan dan mengakibatkan muntah yang menimbulkan iritasi pada saluran pencernaan dan menimbulkan gejala keracunan.
Tujuan: Penelitian ini bertujuan untuk mengetahui adanya lipstick yang mengandung Rhodamin B.
Metode: Metode penelitian yang dilakukan pada penelitian kualitatif dilakukan dengan Kromatografi Lapis Tipis (KLT) dan penelitian kuantitatif dengan Spektrofotometri UV-VIS.
Hasil: Sampel lipstik terbukti secara kualitatif mengandung rhodamin B dengan fase gerak dan fase diam etanol 70%: ammonia: etil asetat (5:2,5:12,5) dan silika gel 254 nm. Dengan nilai RF sebesar 0,57 Pada penelitian kuantitatif, kadar rhodamin B ditemukan berjumlah 2,598 mg/L.
Kesimpulan: Dibuat lipstick yang beredar di kecamatan Banjarmasin Utara terbukti mengandung rhodamin B.
Pengaruh Efek Samping Obat Terhadap Kepatuhan Penggunaan Obat Pada Pasien Penyakit Jantung Koroner Di Rsud Brigjend H.Hasan Basry Hulu Sungai Selatan
Authors: Lathifah Nur , Yuwindry Iwan , Zulfadhilah Muhammad 
Published: December 2022

Latar Belakang: Penyakit jantung koroner (PJK) merupakan suatu keadaan yang disebabkan oleh penyumbatan pada pembuluh darah jantung. PJK merupakan penyakit kardiovaskular penyebab terbanyak kasus kematian diseluruh dunia 45% dari 9,4 juta kematian disebabkan oleh PJK. Kasus PJK di Indonesia mencapai 1,2 juta kasus penderita dan mengalami peningkatan menjadi 2,7 juta orang yang mengalami PJK. Adanya Efek samping obat PJK dan putusnya terapi obat merupakan salah satu fakor risiko terjadinya kegagalan pengobatan.
Tujuan: Menganalisis pengaruh efek samping obat terhadap kepatuhan penggunaan obat pada pasien PJK di RSUD Brigjend H.Hasan Basry Hulu Sungai Selatan.
Metode: Jenis penelitian kuantitatif menggunakan rancangan observasional analitik dengan desain Cross Sectional dan jenis Purposive Consecutive Sampling. Periode sampling selama 4 minggu dengan sampel 50 responden penderita PJK. Analisis data menggunakan analisa univariat dan bivariat dengan uji Spearman Rho. Instrument penelitian menggunakan kuesioner Naranjo untuk efek samping obat dan MMAS-8 untuk kepatuhan.
Hasil: Hasil dari penelitian ini menunjukan bahwa ada korelasi yang terjadi antara variabel efek samping obat PJK dengan kepatuhan penggunaan obat yang menunjukan adanya pengaruh dengan nilai signifikansi 0,001 dan koefisien korelasi 0,470 yang memiliki arah korelasi positif dengan kekuatan hubungan sedang.
Simpulan: adanya pengaruh yang signifikan antara pengaruh efek samping obat PJK terhadap kepatuhan penggunaan obat pada pasien PJK di RSUD Brigjend H.Hasan Basry Hulu Sungai Selatan.
BARRIER DAN SELF-EFFICACY APOTEKER DALAM PROMOSI KESEHATAN DI FASILITAS KESEHATAN TINGKAT PERTAMA KOTA BANJARBARU
Authors: Mardiati Nurul , Munajad Elsa , Hidayati Rahmi 
Published: December 2022

Latar belakang: Promosi kesehatan lebih memfokuskan pada menjaga dan meningkatkan derajat kesejahteraan daripada mengembalikan kesehatan akibat dari sakit atau kecelakaan. Barrier adalah hambatan atau kendala yang dialami oleh apoteker dalam melaksanakan promosi kesehatan, sementara itu pada Self- efficacy ataupun keyakinan diri merupakan suatu perilaku positif orang yang percaya akan keahlian dirinya untuk meningkatkan evaluasi positif, baik terhadap diri sendiri maupun lingkungan.
Tujuan: Riset ini bertujuan guna mengetahui gambaran Barrier, serta Self- efficacy dalam promosi kesehatan dan hubungan antara Barrier serta Self- efficacy dalam melakukan promosi kesehatan.
Metode: Riset ini menggunakan pendekatan cross sectional serta Responden dipilih dengan memakai metode purposive sampling ialah dengan memberikan kuesioner kepada 20 orang Apoteker.Hasil: Sebagian besar apoteker yaitu 13 orang (65%) memiliki barrier yang tinggi dalam promosi kesehatan di FKTP Kota Banjarbaru. Barrier tinggi dalam kurangnya waktu (70 %) dan tidak adanya pedoman standar bagi apoteker (65 %). Mayoritas apoteker juga memiliki self-efficacy yang tinggi yaitu 12 orang (60%). Terdapat hubungan antara barrier dan self-efficacy dalam melaksanakan promosi kesehatan yang dilakukan oleh apoteker yang bekerja di FKTP Kota Banjarbaru.

Kesimpulan: Ada hubungan antara Barrier dan Self-efficacy dalam melaksanakan promosi kesehatan.
Penentuan Nilai Sun Protecting Factor (SPF) Dan Uji Karakteristik Sifat Fisik-Kimia Sediaan Nanoherbal Bedak Dayak
Authors: Nugroho Wahyu , Ayuchecaria Noverda , Aryzki Saftia 
Published: December 2022

Latar belakang: Salah satu produk kearifan lokal yang banyak digunakan masyarakat dayak untuk mengurani efek buruk sinar matahari adalah bedak dayak atau bedak dingin. Berbahan dasar beras yang dicampur dengan beberapa herbal lokal, bedak dayak dimanfaatkan untuk merawat kesehatan dan kecantikan kulit. Bedak dayak memiliki potensi untuk menjadi alternatif untuk melindungi kesehatan kulit dari ancaman radiasi sinar UV ini. Pada penelitian ini sampel yang digunakan telah berupa sediaan nanopartikel. Pemanfaatan teknologi di bidang nano material diharapkan mampu meningkatkan kinerja bioaktivitasnya dan kenyamanan pemakaian jika dibandingkan dengan bedak dayak konvensional
Tujuan: Penelitian ini bertujuan untuk mengetahui aktivitas tabir surya dan karakteristik fisik-kimia sediaan nanoherbal bedak dayak.
Metode: Uji aktivitas tabir surya dilakukan secara in vitro dengan spektrofotometri UV-Vis. Penentuan nilai sun protection factor (SPF) dibaca pada panjang gelombang 290-320nm. Selain itu dilakukan juga uji karakteristik fisika-kimia sediaan meliputi organoleptik, homogenitas, pH, daya sebar dan daya lekat.
Hasil: Hasil pengujian diperoleh nilai SPF sediaan bedak dayak berukuran nanopartikel pada konsentrasi 200 dan 400 ppm berada pada kategori perlindungan minimal (nilai SPF 1-4) sedangkan untuk konsentrasi 600ppm keduanya berada pada kategori perlindungan sedang (nilai SPF 4-6). Hasil uji karakteristik orgoleptis dan homogenitas tidak mengalami perubahan hingga hari ke 14. Uji pH menunjukkan hasil 5,87. Uji daya sebar tanpa beban menunjukan diameter rata-rata sebesar 2,47 cm dan daya lekat 2,33 detik.

Kesimpulan:Nilai SPF yang diperoleh pada konsentrasi 400ppm berada di kategori perlindungan sedang. Sediaan memenuhi persyaratan organoleptis, homogenitas, pH, daya sebar dan daya lekat
How are schools implementing a universal social–emotional learning program? Macro- and school-level factors associated with implementation approach
Authors: Thierry Karen L. , Page Amanda , Currie Cailin , Posamentier Jordan , Liu Yangyang , Choi Jane , Randall Haleigh , Rajanbabu Poojashree , Kim Tia E. , Widen Sherri C. 
Published: December 2022

IntroductionFor universal SEL programs to contribute to positive learning environments, all school staff must be involved in implementing the program (CASEL, 2020). The first aim of the current study was to examined school/district- and macro-level factors associated with two approaches to SEL program implementation observed in schools: (1) classroom teachers as instructors of SEL lessons (i.e., teacher-facilitated) or (2) school counselors as instructors of SEL lessons (i.e., counselor-facilitated). A second aim was to examine the SEL provider’s perception of the context of counselor-facilitated implementation in schools.MethodsPublic elementary and middle schools in the U.S. (N = 6,657), that adopted the Second Step digital program in the 2021-22 school year, were identified as utilizing teacher- or counselor-facilitated implementation using usage records. Predictor variables, namely support for SEL (i.e., state plans to utilize federal funding for SEL programs or access to systemic SEL consultation) and state adoption of stand-along K-12 SEL standards/competencies, were obtained from publicly available data sources. To evaluate the second aim, interviews were conducted with Second Step client support staff (N = 5), each representing hundreds of schools utilizing a counselor-facilitated implementation approach.ResultsA Generalized Linear Mixed Model analysis indicated that schools in states with support for SEL (i.e., plans to utilize federal funding for SEL programs or access to systemic SEL consultation) were more likely to use teacher-facilitated implementation than schools without support (OR = 1.64, p &lt; .01, CI = 1.15 – 2.34). Schools in states that were early adopters of stand-alone K-12 SEL standards/competencies tended to be more likely than those without K-12 SEL standards/competencies to use teacher-facilitated implementation (OR = 1.70, p = .06, CI = 1.00 – 2.95). A qualitative study involving iInterviews with Second Step staff who support hundreds of schools utilizing counselor-facilitated implementation identified other potential factors motivating counselors as facilitators, including low SEL buy-in and limited staff capacity. Although this approach has challenges, it could be a pathway to teacher-facilitated implementation over time.DiscussionTaken together, findings indicate promising strategies for the promotion of more schoolwide use of SEL programs.
High prevalence of non-alcoholic fatty liver disease in patients with a first episode of acute ischemic stroke. Impact on disability and death
Authors: Canillas Lidia , Soriano-Varela Agnes , Rodríguez-Campello Ana , Giralt-Steinhauer Eva , Cuadrado-Godia Elisa , Broquetas Teresa 
Published: December 2022

IntroductionNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and it is associated with an increased risk of overall mortality being cardiovascular disease the most common cause of mortality. Strategies are needed to identify high risk groups for NAFLD to improve screening approaches. Moreover, there is a lack of information about the prevalence of NAFLD on patients with acute ischemic stroke (AIS) and the influence of NAFLD on the prognosis of the stroke. The aim of the study was to define the prevalence of NAFLD in patients with a first episode of AIS and the secondary aims were to evaluate the prevalence of NAFLD at different ages and its impact on the severity and prognosis of the AIS.Materials and methodsObservational study including consecutive patients admitted for the first AIS from January 2005 to May 2018. Patients with harmful alcohol intake, other liver diseases and malignancies were excluded. Sociodemographic data, cardiovascular risk factors, comorbidities, and blood test at admission were reviewed. NAFLD and liver fibrosis were assessed with the serological scores Fatty Liver Index (FLI) and Fibrosis-4 respectively. NAFLD was defined by a FLI&gt;60. Stroke severity and prognosis were evaluated with the National Institute of Health Stroke Scale and modified Rankin Scale respectively in patients aged from 40 to 79 years old.ResultsWe included 1601 patients, 52.4% were female and median (IQR) age of 77 (66 – 83) years. The 41% of the total cohort had a FLI&gt;60 with different prevalence according to age in decades: in 30-39 years: 35.7%; in 40-49: 47.5%; in 50-59: 51.1%, in 60-69: 56%, in 70-79: 41.4%; in 80-89: 34.9% (p&lt;0.001). The presence of NAFLD did not impact on the severity or the prognosis of stroke. However, patients with NAFLD were younger than those without NAFLD (74 vs. 78; p&lt;0.001).ConclusionPresence of NAFLD did not impact on disability and death after the stroke. However, patients with a first episode of stroke showed a high prevalence of NAFLD, especially at intermediate ages, and therefore, screening for NAFLD should be advisable.
Glucagon-like peptide-2 protects the gastric mucosa via regulating blood flow and metabolites
Authors: Zhang Jing , Ning Jing , Hao Xinyu , Han Xiurui , Fu Wei , Gong Yueqing , Meng Qiao , Ding Shigang , Zhang Jing 
Published: December 2022

IntroductionRefractory peptic ulcers lead to perforation and hemorrhage, which are fatal. However, these remain a therapeutic challenge. Gastric mucosal blood flow is crucial in maintaining gastric mucosal health. It’s reported that Glucagon-like peptide-2 (GLP-2), a gastrointestinal hormone, stimulated intestinal blood flow. However, the direct role of GLP-2 in gastric mucosal blood flow and metabolites remain unclear. Here, we speculated that GLP-2 might protect the gastric mucosa by increasing gastric mucosal blood flow and regulating metabolites. This study was conducted to evaluate the role of GLP-2 in gastric mucosal lesions and its underlying mechanism.MethodsWe analyzed endogenous GLP-2 during gastric mucosal injury in the serum. Rats were randomly divided into two groups, with 36 rats in each group as follows: (1) normal control group (NC1); (2) ethanol model group (EC1); rats in EC1 and NC1 groups were intragastrically administered ethanol (1 ml/200 g body weight) and distilled water (1 ml/200 g body weight). The serum was collected 10 min before intragastric administration and 15, 30, 60, 90, and 120 min after intragastric administration. Furthermore, additional male Sprague–Dawley rats were randomly divided into three groups, with six rats in each group as follows: (1) normal control group (NC); (2) ethanol model group (EC); (3) 10 μg/200 g body weight GLP-2 group (GLP-2). Rats in the NC and EC groups were intraperitoneally injected with saline. Those in the GLP-2 group were intraperitoneally injected with GLP-2. Thirty minutes later, rats in the EC and GLP-2 groups were intragastrically administered ethanol (1 ml/200 g body weight), and rats in the NC group were intragastrically administered distilled water (1 ml/200 g body weight). After the intragastric administration of ethanol for 1 h, the animals were anesthetized and gastric mucosal blood flow was measured. Serum were collected for ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) metabolomics.ResultsThere were no significant change in endogenous GLP-2 during gastric mucosal injury (P&lt;0.05). Pretreatment with GLP-2 significantly reduced ethanol-induced gastric mucosal lesions by improving the gastric mucosal blood flow, as examined using a laser Doppler flow meter, Guth Scale, hematoxylin-eosin staining, and two-photon microscopy. UPLC-MS/MS analyses showed that GLP-2 also maintained a steady state of linoleic acid metabolism.ConclusionsTaken together, GLP-2 protects the gastric mucosa against ethanol-induced lesions by improving gastric mucosa blood flow and affecting linoleic acid metabolism.
Genetically predicted C-reactive protein mediates the association between rheumatoid arthritis and atlantoaxial subluxation
Authors: Yuan Jiaqin , Xiong Xiaoqin , Zhang Bin , Feng Qingyuan , Zhang Jinglin , Wang Wenting , Tang Jia 
Published: December 2022

ObjectiveInvestigating the causal relationship between rheumatoid arthritis (RA) and atlantoaxial subluxation (AAS) and identifying and quantifying the role of C-reactive protein (CRP) as a potential mediator.MethodsUsing summary-level data from a genome-wide association study (GWAS), a two-sample Mendelian randomization (MR) analysis of genetically predicted rheumatoid arthritis (14,361 cases, and 43,923 controls) and AAS (141 cases, 227,388 controls) was performed. Furthermore, we used two-step MR to quantitate the proportion of the effect of c-reactive protein-mediated RA on AAS.ResultsMR analysis identified higher genetically predicted rheumatoid arthritis (primary MR analysis odds ratio (OR) 0.61/SD increase, 95% confidence interval (CI) 1.36-1.90) increased risk of AAS. There was no strong evidence that genetically predicted AAS had an effect on rheumatoid arthritis risk (OR 1.001, 95% CI 0.97-1.03). The proportion of genetically predicted rheumatoid arthritis mediated by C-reactive protein was 3.7% (95%CI 0.1%−7.3%).ConclusionIn conclusion, our study identified a causal relationship between RA and AAS, with a small proportion of the effect mediated by CRP, but a majority of the effect of RA on AAS remains unclear. Further research is needed on additional risk factors as potential mediators. In clinical practice, lesions of the upper cervical spine in RA patients need to be given more attention.
Pharmacological potential of Sargassum sp. of west coast of Maharashtra Kunkeshwar, India
Authors: Abdi Gholamreza , Karande Vanita Chandrashekhar , Mohammed Arifullah , Abbasi Tarighat Maryam , Wen Goh Khang , Abdul Kari Zulhisyam , Seong Wei Lee , Ahmad Mohd Zain Muhammad Rajaei , Mohammadi Mehdi , Ee Lee Gaik , Barwant Mukul M. 
Published: December 2022

A promising plant group that is important in medicine is the seaweed. In this investigation, we have focused on the pharmacological prospects of brown algae (Sargassum sp). Nutraceuticals refer to products that may combine pharmacological and nutrition. We have collected the plant material close to Kunkeeshwar in Sindhudurg, Maharashtra’s western coast. We focused on the Physicochemical Attributes of Sargassum sp., and the study found that the ash value (41 ± 0.67), moisture content (1.33 ± 0.038), alcohol-soluble extractive value (1.5 ± 0.030), moisture content (1.33 ± 0.038), and total cash value (41 ± 0.67) are all stated in (%).The GCMS findings, which demonstrate that a total of 25 chemicals were discovered in the aqueous extract of Sargassum sp., also represent their nutritional profile. All of these substances have chromatograms that can be observed.1-Hexyl-2-nitrocyclohexane is the substance with the second-largest retention duration and relative areas, followed by n-hexadanoic acid. The presence of ocladecanoic acid was later determined. The explanation for how the activity is concentration-dependent is pharmacological activity, particularly antioxidant activity as shown by the DPPH assay.2μg/mL is -1545.4 ± 0.05. as a minimum. and at (32 g/mL is 7.67 ± 0.05) is the highest. The antifungal activity of Candida albicans (12.8 mm) and Aspergillus niger (14.4 mm) both exhibit zone inhibition when tested against two distinct pathogen however, the antibacterial activity of three different bacteria demonstrates that Staphylococcus aureus (12 mm), Bacillus subtilis (10 mm), Proteus mirabilis (12.8 mm), and Escherichia. coli are all zone inhibited (13mm). Brown algae offer the greatest potential for human health nutrition, while pharmacological analysis is helpful for therapeutic application, according to the overall analysis.
Development of a model for predicting the severity of chronic obstructive pulmonary disease
Authors: Gu Yu-Feng , Chen Long , Qiu Rong , Wang Shu-Hong , Chen Ping 
Published: December 2022

BackgroundSeveral models have been developed to predict the severity and prognosis of chronic obstructive pulmonary disease (COPD). This study aimed to identify potential predictors and construct a prediction model for COPD severity using biochemical and immunological parameters.MethodsA total of 6,274 patients with COPD were recruited between July 2010 and July 2018. COPD severity was classified into mild, moderate, severe, and very severe based on the Global Initiative for Chronic Obstructive Lung Disease guidelines. A multivariate logistic regression model was constructed to identify predictors of COPD severity. The predictive ability of the model was assessed by measuring sensitivity, specificity, accuracy, and concordance.ResultsOf 6,274 COPD patients, 2,644, 2,600, and 1,030 had mild/moderate, severe, and very severe disease, respectively. The factors that could distinguish between mild/moderate and severe cases were vascular disorders (OR: 1.44; P &lt; 0.001), high-density lipoprotein (HDL) (OR: 1.83; P &lt; 0.001), plasma fibrinogen (OR: 1.08; P = 0.002), fructosamine (OR: 1.12; P = 0.002), standard bicarbonate concentration (OR: 1.09; P &lt; 0.001), partial pressure of carbon dioxide (OR: 1.09; P &lt; 0.001), age (OR: 0.97; P &lt; 0.001), eosinophil count (OR: 0.66; P = 0.042), lymphocyte ratio (OR: 0.97; P &lt; 0.001), and apolipoprotein A1 (OR: 0.56; P = 0.003). The factors that could distinguish between mild/moderate and very severe cases were vascular disorders (OR: 1.59; P &lt; 0.001), HDL (OR: 2.54; P &lt; 0.001), plasma fibrinogen (OR: 1.10; P = 0.012), fructosamine (OR: 1.18; P = 0.001), partial pressure of oxygen (OR: 1.00; P = 0.007), plasma carbon dioxide concentration (OR: 1.01; P &lt; 0.001), standard bicarbonate concentration (OR: 1.13; P &lt; 0.001), partial pressure of carbon dioxide (OR: 1.16; P &lt; 0.001), age (OR: 0.91; P &lt; 0.001), sex (OR: 0.71; P = 0.010), allergic diseases (OR: 0.51; P = 0.009), eosinophil count (OR: 0.42; P = 0.014), lymphocyte ratio (OR: 0.93; P &lt; 0.001), and apolipoprotein A1 (OR: 0.45; P = 0.005). The prediction model correctly predicted disease severity in 60.17% of patients, and kappa coefficient was 0.35 (95% CI: 0.33–0.37).ConclusionThis study developed a prediction model for COPD severity based on biochemical and immunological parameters, which should be validated in additional cohorts.