bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interdependence of fucoxanthin biosynthesis and fucoxanthin-chlorophyll a/c binding proteins in Phaeodactylum tricornutum under different light intensities
Authors: Truong To Quyen , Park Yun Ji , Koo Song Yi , Choi Jae-Hyeong , Enkhbayar Altai , Song Dae-Geun , Kim Sang Min 
Published: October 2022

AbstractFucoxanthin (FX), a primary carotenoid, is associated with the fucoxanthin-chlorophyll a/c binding protein (FCP) complex integrated into the thylakoid membrane (TM) which functions as a light-harvesting complex in the diatom Phaeodactylum tricornutum. Here, we aimed to elucidate the FX production regulated by different light intensities via the correlation of FX biosynthesis and apoproteins composing of FCP complex. High light (HL) accelerated P. tricornutum growth more than low light (LL). The maximum values of FX content and productivity obtained under LL (1.7 mg g−1 and 2.12 mg L−1 day−1, respectively) were substantially higher than those obtained under HL (0.54 mg g−1 and 0.79 mg L−1 day−1, respectively). Notably, proteome and photosynthetic pigment analyses revealed the enrichment of FCP antennae in the LL culture TM fractions but not the HL culture. Semi-quantification of FCP antenna protein using LC–MS/MS and RNA transcriptome analyses revealed that PtLhcf5 and PtLhcf8 played crucial roles in FCP biosynthesis under LL. P. tricornutum cultured under light transition exhibited FCP formation only in the early growth stage to meet the increased photosynthetic activity requirements under LL. Meanwhile, FCP degradation could be triggered by HL throughout the cultivation period. Therefore, FX production was highly correlated with FCP formation, and LL conditions in the early growth stage were critical for higher FX productivity.
Development of a surrogate model for high-fidelity laser powder-bed fusion using tensor train and gaussian process regression
Authors: Kizhakkinan Umesh , Duong Pham Luu Trung , Laskowski Robert , Vastola Guglielmo , Rosen David W. , Raghavan Nagarajan 
Published: October 2022

AbstractA multi-physics high-fidelity computational model is required to study the melting and grain growth phenomena in a laser powder-bed fusion (LPBF) additive manufacturing process. The major challenge with the high-fidelity model is long computational time, which makes it unsuited for any feasible process parameter optimization study in a high dimensional process design space. To address this challenge, surrogate models are a good option to replace the high-fidelity model, resulting in a significant shortening of the computational time at the expense of an acceptable drop in accuracy. In this study, a tensor train (TT) and Gaussian process regression (GPR) based methodology is proposed to develop a surrogate of the high-fidelity powder-scale model. An in-house developed powder-scale model is used to generate the training data by simulating a microscale model of the powder-bed for different values of laser power. The trained TT-GPR model can predict the thermal history of the powder-bed and melt pool geometry for a specified value of laser power, while the computation time required for prediction of any set of process conditions is less than one second. Here we can achieve an approximate computational speedup of 10$$^4$$

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with the surrogate model. We provide evidence to claim that the proposed surrogate model provides high computational efficiency without compromising accuracy.
High-Temperature Oxidation Behaviour of a TiAl-Based Alloy Subjected to Aluminium Hot-Dipping
Authors: Pilone D. , Mondal A. , Zortea L. 
Published: October 2022

AbstractIn this research the oxidation resistance at high temperature of a TiAl-based alloy has been improved by hot-dipping the alloy in molten aluminium and by performing an interdiffusion process. After selecting the best process parameters, a compact TiAl3 coating characterized by an almost constant thickness was formed on the surface. Isothermal oxidation tests, carried out at 900, 950 and 1000 °C, showed that the coated alloy is able to form a continuous and thin alumina layer that is very protective. Microstructural investigations highlighted that, above 900 °C, long residence times at high temperature determine the diffusion through the TiAl3 layer of Cr that favours migration toward the outer surface of Al and thus the formation of a self-healing alumina layer.
Graphical Abstract
Quality principles of retrospective data collected through a life history calendar
Authors: Chevallereau Julie , Berchtold André 
Published: October 2022

AbstractTo assert the quality of retrospective data, most studies using tools such as life history calendars rely on comparisons with external sources. Our research aimed to integrate quality principles into a life history calendar and test their capacity to evaluate the data quality. The purpose was to avoid reliance on external data sources because of their possible unavailability. The first quality principle was the relationship between the dating accuracy of verifiable events and the data quality of the life domains of the calendar. The second was the certainty, as self-assessed by participants through color coding, that an event took place at the quarter indicated. We designed an experiment using a paper-and-pencil life history calendar that was completed by 104 university students. Our research highlighted the relevance to use the self-assessment of certainty to assert the data quality. However, we could not establish a relationship between the dating accuracy of verifiable events and the data quality of the life domains. In addition, we present a set of qualitative findings from 20 interviews conducted with study participants explaining the approaches used to complete a life calendar and the difficulties encountered.
Representative random sampling: an empirical evaluation of a novel bin stratification method for model performance estimation
Authors: Rendleman Michael C. , Smith Brian J. , Canahuate Guadalupe , Braun Terry A. , Buatti John M. , Casavant Thomas L. 
Published: October 2022

AbstractHigh-dimensional cancer data can be burdensome to analyze, with complex relationships between molecular measurements, clinical diagnostics, and treatment outcomes. Data-driven computational approaches may be key to identifying relationships with potential clinical or research use. To this end, reliable comparison of feature engineering approaches in their ability to support machine learning survival modeling is crucial. With the limited number of cases often present in multi-omics datasets (“big p, little n,” or many features, few subjects), a resampling approach such as cross validation (CV) would provide robust model performance estimates at the cost of flexibility in intermediate assessments and exploration in feature engineering approaches. A holdout (HO) estimation approach, however, would permit this flexibility at the expense of reliability. To provide more reliable HO-based model performance estimates, we propose a novel sampling procedure: representative random sampling (RRS). RRS is a special case of continuous bin stratification which minimizes significant relationships between random HO groupings (or CV folds) and a continuous outcome. Monte Carlo simulations used to evaluate RRS on synthetic molecular data indicated that RRS-based HO (RRHO) yields statistically significant reductions in error and bias when compared with standard HO. Similarly, more consistent reductions are observed with RRS-based CV. While resampling approaches are the ideal choice for performance estimation with limited data, RRHO can enable more reliable exploratory feature engineering than standard HO.
Equity in AgeTech for Ageing Well in Technology-Driven Places: The Role of Social Determinants in Designing AI-based Assistive Technologies
Authors: Rubeis Giovanni , Fang Mei Lan , Sixsmith Andrew 
Published: October 2022

AbstractAgeTech involves the use of emerging technologies to support the health, well-being and independent living of older adults. In this paper we focus on how AgeTech based on artificial intelligence (AI) may better support older adults to remain in their own living environment for longer, provide social connectedness, support wellbeing and mental health, and enable social participation. In order to assess and better understand the positive as well as negative outcomes of AI-based AgeTech, a critical analysis of ethical design, digital equity, and policy pathways is required. A crucial question is how AI-based AgeTech may drive practical, equitable, and inclusive multilevel solutions to support healthy, active ageing.In our paper, we aim to show that a focus on equity is key for AI-based AgeTech if it is to realize its full potential. We propose that equity should not just be an extra benefit or minimum requirement, but the explicit aim of designing AI-based health tech. This means that social determinants that affect the use of or access to these technologies have to be addressed. We will explore how complexity management as a crucial element of AI-based AgeTech may potentially create and exacerbate social inequities by marginalising or ignoring social determinants. We identify bias, standardization, and access as main ethical issues in this context and subsequently, make recommendations as to how inequities that stem form AI-based AgeTech can be addressed.
A novel set of volatile urinary biomarkers for late-life major depressive and anxiety disorders upon the progression of frailty: a pilot study
Authors: Fujita Akiko , Ihara Kazushige , Kawai Hisashi , Obuchi Shuichi , Watanabe Yutaka , Hirano Hirohiko , Fujiwara Yoshinori , Takeda Yoichi , Tanaka Masashi , Kato Keiko 
Published: October 2022

AbstractMood and anxiety disorders are frequent in the elderly and increase the risk of frailty. This study aimed to identify novel biomarkers of major depressive disorder (MDD) and anxiety in the elderly. We examined 639 participants in the community-dwelling Otassha Study (518 individuals considered healthy control, 77 with depression, anxiety, etc.), mean age 75 years, 58.4% of female. After exclusion criteria, we analyzed VOCs from 18 individuals (9 healthy control, 9 of MDD/agoraphobia case). Urinary volatile and semi-volatile organic compounds (VOCs) were profiled using solid-phase microextraction and gas chromatography-mass spectrometry. Six urinary VOCs differed in the absolute area of the base peak between participants with MDD and/or agoraphobia and controls. High area under the receiver-operating characteristic curve (AUC) values were found for phenethyl isothiocyanate (AUC: 0.86, p = 0.009), hexanoic acid (AUC: 0.85, p = 0.012), texanol (AUC: 0.99, p = 0.0005), and texanol isomer (AUC: 0.89, p = 0.005). The combined indices of dimethyl sulfone, phenethyl isothiocyanate, and hexanoic acid, and texanol and texanol isomer showed AUCs of 0.91 (p = 0.003) and 0.99 (p = 0.0005) and correlated with the GRID-HAMD and the Kihon Checklist (CL score), respectively. These VOCs may be valuable biomarkers for evaluating MDD and/or agoraphobia in the elderly.
Weaponizing Energy: Energy, Trade, and Investment Law in the New Geopolitical Reality
Authors: Boute Anatole 
Published: October 2022

AbstractConcerns over the weaponization of energy during the war in Ukraine have revived state anxieties about overreliance on certain foreign energy sources. This Essay argues that instruments of energy trade and investment protection have helped to lock states into dangerous dependencies. Trade and investment law can inhibit energy security strategies designed to diversify away from unreliable sources and to block suspicious investors. With energy used as a weapon, reform of the liberal energy regime is needed to allow states to prevent the creation of dependencies and protect their energy security in the new geopolitical reality.
Making Sense of Electoral Violence: The Narrative Frame of Organised Crime in Mexico
Authors: Schedler Andreas 
Published: October 2022

AbstractSince the inauguration of Mexican democracy in 2000, organised criminal violence had been leaking into the political arena. Yet, it escalated in the 2018 elections, when dozens of local candidates were killed. In most of these cases, the concrete perpetrators and motives remained in the dark. How did Mexican society make sense of this opaque, unprecedented wave of electoral violence? On the basis of a qualitative content analysis of over 1,200 news reports, I examine the structuring power of a shared narrative: the frame of organised crime. By conceiving candidate killings as economic violence within the criminal community, this commonsensical frame of interpretation permitted Mexican society to ‘normalise’ these killings as ‘business as usual’ by criminal organisations.
When a Free Act Costs a Motive: Clearing Consequentialism of Conflict
Authors: McDougal Austen 
Published: October 2022

AbstractConsequentialist theories that directly assess multiple focal points face an important objection: that one right option may conflict with another. Robert Adams raises an instance of this objection regarding the possibility that the right act conflicts with the right motives. Whereas only partial responses have previously been given, assuming particular views of the relation between motives and acts, an exhaustive treatment is in order. Either motives psychologically determine acts, or they do not – and I defend direct consequentialism on each assumption. Crucially, if motives determine acts, this may be compatible with the ability to act otherwise, but there remains a defense for consequentialism even on these assumptions. What clears consequentialism of conflict is not necessarily that the apparently right act is unavailable, but rather that its outcome is suboptimal once we account for necessary motives. Even if the agent remains free to perform the act, the act costs too much.
But parents need help! Pathways to caregiver mental health care in pediatric hospital settings
Authors: Salley Christina G. , Axelrad Marni , Fischer Elizabeth , Steuer Katherine B. 
Published: October 2022

AbstractObjectivesResearch and clinical expertise have emphasized the mental health needs of parents and caregivers of medically complex children. Evidence-based interventions are available for adult mental health, including those designed specifically for caregivers caring for children with a variety of health-care needs. This paper describes practical and legal considerations of 3 possible pathways for psychologists to address the needs of caregivers within pediatric hospital settings.MethodsLiterature regarding the mental health needs of caregivers of children with medical conditions, evidence-based interventions, and pediatric subspecialty psychosocial guidelines was reviewed. Relevant legal and ethical obligations for psychologists were also summarized.ResultsThe mental health needs of caregivers of medically complex children are often high, yet programmatic, institutional, legal, and ethical barriers can limit access to appropriate care.Significance of the resultsIntegration of screening and treatment of caregivers’ mental health within the pediatric hospital setting is one pathway to addressing caregivers’ needs. The development of programs for caregiver mental health screening and treatment within pediatric hospital settings will enhance the well-being of children and families and reduce legal and ethical risks for pediatric psychologists. Consultation with institutional compliance, legal/risk, and medical records departments and the creation of electronic medical records for the caregiver may be useful and practical opportunities for integration.
Characteristics of overseas Chinese residents and the background behind the formation of their settlements in the Song period
Authors: Go Eunmi 
Published: October 2022

AbstractTo date, the research on Chinese figures residing or settling abroad and their residential settlements has mainly focused on trade merchants. Merchants frequently traveled abroad due to the characteristics of their occupation and were therefore more likely to reside in foreign countries for varying periods of time in the process. Song-era records that document figures staying overseas, however, largely center around intellectuals and bureaucrats who were trained in the Chinese systems of knowledge or administration, as opposed to merchants. Examining the records concerned, it is difficult to conclude that merchants accounted for the majority of overseas Chinese citizens at that time. This paper strived to focus on the emergence of people who looked for opportunities overseas as the background for the formation of Chinese communities in the Song period, as opposed to trade voyages by merchants. This situation is clearly revealed through the Song's ban on overseas travel for those with different traits from merchants. This indicates that the emergence of people who sought to journey abroad for new opportunities had begun even before 1078. As Chinese citizens sailed abroad to look for new opportunities, Chinese communities began to form in foreign countries around the twelfth century.
Coupling receiver–transmitter metasurface-based Fabry–Pérot resonant antenna with dual circular polarization
Authors: Yuan Zhiqiang 
Published: October 2022

AbstractThis study presents a dual-circularly polarized (CP) Fabry–Pérot (FP) antenna, employing a novel receiver–transmitter (RT) metasurface (MS). The RT-MS unit cell consists of two identical neighboring substrates, with a three-layer metal coating printed on their surfaces. The bottom patch is adopted as a receiver to transfer electromagnetic waves to the top-corner cut patch, passing through the coupling cross-slot sandwiched in the middle. The RT-MS has high reflectivity to achieve a high gain. Through energy and a cross-slot, high aperture efficiency can be realized. A conventional corner cut patch can excite a CP mode of equal magnitude and a 90° phase difference. The RT-MS is arranged in 12 × 12 unit cells and used as a superstrate for a dual-CP antenna. Two orthogonally etched slots fed by two branch-matched orthogonally arranged feed lines are used as feeders to produce perpendicular linearly polarized waves. To enhance the bandwidth and improve the gain, double identical stack substrate patches are placed at the top side of the slot with no air gap, for a wide impedance band and high gain. Two wide CP bands, left-hand circular polarization and right-hand circular polarization, of 12.21–13.1 GHz (7.03%) and 12.35–13.1 GHz (5.89%), respectively, have maximum high gains of 16.5 and 15.97 dBic at 12.58 and 12.7 GHz, respectively, with a compact size of 2.6λ0 × 2.6λ0, suggesting better properties than recent antennas. The aperture efficiency can reach 63.2%. Thus, the RT-MS-based FP antenna is a good candidate for commercial and military communication systems.
The origins and influence of victim assistance: Contributions of the Mine Ban Treaty, Convention on the Rights of Persons with Disabilities and Convention on Cluster Munitions
Authors: Docherty Bonnie , Sanders-Zakre Alicia 
Published: October 2022

AbstractThe establishment of victim assistance as a core element of humanitarian disarmament emerged from three treaties: the 1997 Mine Ban Treaty (MBT), the 2006 Convention on the Rights of Persons with Disabilities (CRPD) and the 2008 Convention on Cluster Munitions (CCM). The MBT introduced the concept of victim assistance, and the CPRD created a framework of human rights that influenced its evolution. Drawing on its predecessors, the CCM made victim assistance a robust and rights-based legal obligation. This article analyses the negotiating history and content of the treaties to show how victim assistance evolved, particularly in the areas of inclusion and human rights. It examines the treaties’ implementation, which reveals that while the CRPD set standards for victim assistance, the MBT and CCM's victim assistance programmes have benefitted persons with disabilities in practice. Finally, it offers lessons from the MBT, CRPD and CCM for implementation and interpretation of victim assistance obligations under the 2017 Treaty on the Prohibition of Nuclear Weapons. The article concludes that the three treaties have collectively established assisting victims as a feature of disarmament law, helped persons with disabilities realize their rights, and laid the groundwork for adapting victim assistance to new challenges.
Protection of persons with disabilities in armed conflict under international humanitarian law and Islamic law
Authors: Al-Dawoody Ahmed , Pons William I. 
Published: October 2022

AbstractArticle 11 of the Convention on the Rights of Persons with Disabilities requires that the rights and protections of the Convention not be derogated or suspended during “situations of risk, including situations of armed conflict”. Even so, persons with disabilities are still often the group most disproportionately impacted by armed conflict. This reality is not due to a failing of international humanitarian law to protect and consider persons with disabilities; rather, it is due to a failure to mainstream disability into the application of and approach to existing protection frameworks. Impactful mainstreaming of disability necessitates the inclusion of all relevant mutually reinforcing legal frameworks and traditions. By examining four main areas – military operations, evacuation, humanitarian assistance, and long-term assistance and services – this paper argues that the protection of persons with disabilities in armed conflict, and specifically within Muslim contexts, will be enhanced through the inclusion and consideration of Islamic law.
Crustal Structure Constraints From the Detection of the SsPp Phase on Mars
Authors: Li Jiaqi , Beghein Caroline , Davis Paul , Wieczorek Mark. A. , McLennan Scott M. , Kim Doyeon , Lekić Ved , Golombek Matthew , Schimmel Martin , Stutzmann Eleonore , Lognonné Philippe , Banerdt William Bruce 
Published: October 2022

AbstractThe shallowest intracrustal layer (extending to 8 ± 2 km depth) beneath the Mars InSight Lander site exhibits low seismic wave velocity, which is likely related to a combination of high porosity and other lithological factors. The SsPp phase, an SV‐ to P‐wave reflection on the receiver side, is naturally suited for constraining the seismic structure of this top crustal layer since its prominent signal makes it observable with a single station without the need for stacking. We have analyzed six broadband and low‐frequency seismic events recorded on Mars and made the first coherent detection of the SsPp phase on the red planet. The timing and amplitude of SsPp confirm the existence of the ∼8 km interface in the crust and the large wave speed (or impedance) contrast across it. With our new constraints from the SsPp phase, we determined that the average P‐wave speed in the top crustal layer is between 2.5 and 3.2 km/s, which is a more precise and robust estimate than the previous range of 2.0–3.5 km/s obtained by receiver function analysis. The low velocity of Layer 1 likely results from the presence of relatively low‐density lithified sedimentary rocks and/or aqueously altered igneous rocks that also have a significant amount of porosity, possibly as much as 22%–30% by volume (assuming an aspect ratio of 0.1 for the pore space). These porosities and average P‐wave speeds are compatible with our current understanding of the upper crustal stratigraphy beneath the InSight Lander site.