bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is There Any Correlation between Anti-Ro 52 Antibody Level with Hematological Abnormalities in Systemic Lupus Erythematosus?
Authors: Diredja Andiyang R. , Oehadian Amaylia , Hamijoyo Laniyati 
Published: July 2022

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various clinical and serological manifestations. Previous studies have shown conflicting results about the association of anti-Ro 52 autoantibodies with hematological abnormalities in SLE. We investigated the correlation between anti Ro 52 autoantibody with anemia, leucopenia, and thrombocytopenia in patients with SLE.
Methods: Sixty-two bio archives serum of an SLE patient at the Division of Rheumatology, Department of Internal Medicine, Hasan Sadikin General Hospital, Bandung, Indonesia from 2017 to 2019 were enrolled in the study. Anti-Ro 52 levels were examined using the ELISA method. The clinical data, treatment, and hematology paparametersere were analyzed retrospectively.
Results: Among 62 bio-archive serum, four subjects were excluded because of incomplete data. Fifty-eight patients, all females were enrolled. We identified 57 (98.3%) subjects corticosteroid, 31 (53.4%) azathioprine and 28 (48.3%) chloroquine. A correlation coefficient of anti-Ro 52 levels and hemoglobin, leukocyte and platelets were -0.037 (p = 0.391), 0.065 (p = 0.315) and 0.092 (p = 0.246), respectively.
Conclusion: No correlation was found between anti Ro 52 antibody levels with haematological abnormalities in patients with SLE. Further studies need to evaluate whether other antibodies play important role in haematological abnormalities in SLE.
Adult-Onset Still's Disease (AOSD): A Case Report
Authors: Muhammad Reagan  , Partan Radiyati Umi 
Published: July 2022

Background: Adult-Onset Still's Disease (AOSD) is a rare multisystemic autoinflammatory disorder with an unknown etiology, and the diagnosis is difficult due to various differential diagnoses. AOSD diagnosis is getting better because medical developments and therapeutic strategies from various studies have benefited from advances in understanding autoinflammatory and autoimmune diseases.
Case presentation. A woman patient has a complaint of periodic high fever with joint pain for more than 1 month and reddish spots on the skin, fatigue, and menstrual disorders. Patients had been treated several times and performed a blood transfusion, but complaints still occur frequently. The patient is diagnosed with Adult-Onset Still’s Disease with secondary amenorrhoea.
Conclusion: This case is rarely found, so it requires quite difficult therapy and diagnostics. Therefore, this case was presented as a case report in order to get better therapy.
Single Case Experience of Immunosuppressant Administration to Systemic Sclerosis-ILD Patients with Aspergilloma
Authors: Anggraini Wilujeng , Perdana Aditya Rahman  
Published: July 2022

Background: Systemic sclerosis (SSc) is a chronic autoimmune disease that still poses a great challenge to clinicians. SSc is characterized by immune dysregulation and progressive fibrosis that typically affects variable internal organ involvement such as lungs. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. The immunosuppressive drug is the main treatment to suppress the inflammation process in SSc.
Case presentation: In this case we report a 40-year-old female to suffer ILD-SSc. According to High-Resolution Computed Tomography (HRCT) thorax, we found that it was interstitial lung disease with aspergilloma. She got methylprednisolone 3x8 mg and azathioprine 2x50 mg. At the end of the treatment, the patient showed improvement in her clinical condition and showed no worsening condition in the HRCT evaluation for her fungal aspergilloma.
Conclusion: Systemic sclerosis (SSc) is a rare autoimmune disease involving the skin and internal organs. The immunosuppressive agent is still the drug of choice for most autoimmune diseases. Immunosuppressive may promote fungal growth and have been associated with increased risk in most serious fungal diseases including aspergilloma.
The All-sky Spectrometer of Hot Cosmic Plasma
Authors: Kambarova Zh. T. , Saulebekov A. O. , Trubitsyn A. A. 
Published: July 2022

Abstract
The main instruments for analyzing the processes occurring in cosmic plasma are energy and mass analyzers of charged particle beams. The analyzers’ operation is based on the separation of charged particles according to the energies of their motion or their masses in electric or magnetic fields. Currently, the top-hat analyzer is considered the main instrument for obtaining information about the state of cosmic plasma. However, it has a number of disadvantages: a significant time cycle for registering angular dependences in a total solid angle of 4π sr and low accuracy of determining the polar angles, which are associated with the need to rotate the analyzer during measurements. Over the past 20 years, plasma analyzers with a large viewing angle have been developed as an alternative to the top-hat analyzer. The design of the analyzer proposed in this work is capable of measuring plasma characteristics in a solid angle of 2π sr in one act of data registration. The all-sky spectrometer of hot cosmic plasma consists of two stages: the first stage is a conical lens of an original design, which serves to transform an extremely wide entrance flow of particles into a narrow cone-shaped beam; the second hexapole-cylindrical stage plays the role of an energy analyzer of a narrow cone-shaped flow. The paper describes the calculations and modeling of the proposed analyzer on the basis of original numerical and approximate analytical methods for designing systems of electron and ion optics. The main parameters of the device are calculated.
The Distribution of Satellite Galaxies in the IllustrisTNG100 Simulation
Authors: McDonough Bryanne , Brainerd Tereasa G. 
Published: July 2022

Abstract
We investigate the spatial distribution of the satellites of isolated host galaxies in the IllustrisTNG100 simulation. In agreement with a previous, similar analysis of the Illustris-1 simulation, the satellites are typically poor tracers of the mean host mass density. Unlike the Illustris-1 satellites, here the spatial distribution of the complete satellite sample is well fitted by an NFW profile; however, the concentration is a factor of ∼2 lower than that of the mean host mass density. The spatial distributions of the brightest 50% and faintest 50% of the satellites are also well fitted by NFW profiles, but the concentrations differ by a factor of ∼2. When the sample is subdivided by host color and luminosity, the number density profiles for blue satellites generally fall below the mean host mass density profiles, while the number density profiles for red satellites generally rise above the mean host mass density profiles. These opposite, systematic offsets combine to yield a moderately good agreement between the mean mass density profile of the brightest blue hosts and the corresponding number density profile of their satellites. Lastly, we subdivide the satellites according to the redshifts at which they joined their hosts. From this, we find that neither the oldest one-third of the satellites nor the youngest one-third of the satellites faithfully trace the mean host mass density.
Detection Feasibility of H2 in Ultra-hot Jupiter Atmospheres
Authors: Morgan Anastasia , Cauley P. Wilson , France Kevin , Youngblood Allison , Koskinen Tommi T. 
Published: July 2022

Abstract
Ultra-hot Jupiters (UHJs) have recently been the focus of several atmospheric studies due to their extreme properties. While molecular hydrogen (H2) plays a key role in UHJ atmospheres, it has not been directly detected on an exoplanet. To determine the feasibility of H2 detection via transmission spectroscopy of the Lyman and Werner bands, we modeled UHJ atmospheres with H2 rotational temperatures varying from 2000 to 4000 K orbiting A-type stars ranging from T
eff = 8500 K to T
eff = 10,300 K. We present simulated transmission spectra for each planet-star temperature combination while adding Poisson noise varying in magnitude from 0.5% to 2.0%. Finally, we cross-correlated the spectra with expected atmospheric H2 absorption templates for each temperature combination. Our results suggest that H2 detection with current facilities, namely the Hubble Space Telescope, is not possible. However, direct atmospheric transmission spectroscopy of H2 may be viable with future UV-capable flagship missions.
CI Asteroid Regolith as an In Situ Plant Growth Medium for Space Crop Production
Authors: Russell Steven. J. , Fieber-Beyer Sherry. K. , Yurkonis Kathryn. A. 
Published: July 2022

Abstract
Human expansion into the solar system is currently at the forefront of space research. For our astronauts to survive, they will need to be fed a healthy and nutritious diet on a consistent basis. Right now, our current method of feeding astronauts consists of resupplied prepackaged food from Earth, which is unsustainable for long-term missions. Using planetary resources via in situ resource utilization to grow crops is the next step toward sustainability in space. Asteroids are an abundant space resource and should not be overlooked when considering crewed missions. In particular, the primordial CI carbonaceous asteroids are of interest because the regolith is suggested to contain soluble elemental nutrients, such as phosphorous and potassium, that crops can use for growth and development. We present a study on the ability of CI carbonaceous asteroid regolith simulant to sustain plant growth of lettuce (Latuca
sativa), radishes (Raphanus
sativus), and peppers (Capsicum
annuum). We tested growing the selected crops in increasing mixtures of simulant and peat moss. The results showed that each species reacted differently to each treatment and that the radishes were more affected by the treatments. Subsequent analysis showed that the simulant contains small amounts of plant-usable nutrients, despite its high pH, low cation exchange capacity, and classification as a silt-based soil. Our results indicate that the simulant is prone to compaction and crusting, leading to drought stress on the crops. Further investigations are needed to determine mitigation strategies to make CI asteroid regolith a more conducive soil.
Study of the effect of acetylsalicylic acid and a selective arginase II inhibitor KUD 975 on the correction of hemostatic disorders in experimental preeclampsia
Authors: Gureeva Anastasia V. , Severinova Olga V. , Gureev Vladimir V. , Kochkarova Indira S. , Avdeyeva Elena V. 
Published: July 2022

Introduction: The disruption of the functional state of the vascular endothelium is among the main causes of pre­eclampsia, which is one of the most common causes of maternal and perinatal mortality. It can be enhanced by the humoral factors secreted by the activated platelets. The use of acetylsalicylic acid is an effective way to prevent pre­eclampsia. However, its ability to activate eNOS is a prerequisite for researching its ability to correct the disorders in developing preeclampsia, including by reducing the platelet activity. In this case its effect can be enhanced through increasing the bioavailability of L-arginine by using a selective arginase II inhibitor KUD 975. These facts were the prerequisite for conducting this study.
Materials and methods: The study was conducted on 180 female Wistar rats weighing 250–300 g. Acetylsalicylic acid was used at a dose of 7 mg/kg/day and 10 mg/kg/day, KUD 975 – at a dose of 1 mg/kg/day and 3 mg/kg/day. Adenosine diphosphate (ADP, 6.5 microns), arachidonic acid (ASPI, 0.5 mM), and collagen (3.2 mcg/ml) were used as aggregation inducers.
Results and discussion: ADMA-like preeclampsia simulation led to an increase in platelet aggregation ability when using all aggregation inducers. This is evidenced by an increase in a degree, rate of aggregation, and a shortened time of thrombus formation. The use of acetylsalicylic acid and a selective arginase II inhibitor KUD 975 led to a decrease in the aggregation ability of platelets and an increase in thrombosis time, while the combined administration of the studied agents showed a more pronounced effect.
Conclusion: The data obtained while performing a series of experiments strongly indicate a promising outlook for using acetylsalicylic acid and a selective arginase II inhibitor KUD 975 in order to correct emerging disorders in preeclampsia.
Quels enjeux socio-économiques pour les données des sciences sociales ?
Authors: Lebaron Frédéric 
Published: July 2022

Résumé : Cet article est l’occasion d’opérer un retour réflexif sur plusieurs années d’expérience de la pratique de recherche en sciences sociales, envisagées à travers les enjeux éthiques de la production et la diffusion des données. Nous y discutons quelques implications de ce que l’on peut appeler « profilage » sociologique des populations, qui consiste à recueillir, analyser et publier, sous une forme ou une autre, des informations relatives à des caractéristiques « objectives », des pratiques ou des opinions des personnes, en incluant des données se présentant sous forme textuelle désormais largement accessibles via les réseaux sociaux. Sont successivement discutés les enjeux autour de la production et la diffusion de données de questionnaires, le cas particulièrement signifiant des données sur les « élites » ainsi que des questions plus générales relatives aux dynamiques des Big Data .
Entre contrainte et ressource : la régionalisation du Bien-être animal comme opportunité politique
Authors: Deting Adeline 
Published: July 2022

Le mouvement animaliste belge se mobilise et déploie ses stratégies d’action dans un contexte politique bien spécifique à la Belgique. Via le concept de « structure des opportunités politiques », issu de la sociologie des mouvements sociaux, nous présentons dans cet article comment ce contexte a pu influencer l’activité de ce mouvement. Nous examinons ici deux transformations du paysage institutionnel belge en lien avec la question animale : d’une part, la création d’un Conseil du Bien-être animal en 1986, ainsi que son évolution et, d’autre part, la régionalisation de la compétence du Bien-être animal en 2014. Ces deux transformations nous ont permis d’analyser simultanément les manières dont les acteurs étatiques définissent l’environnement politique et les façons dont les mouvements sociaux tentent, à leur tour, de le modifier. Nous avons saisi comment, dans un contexte politique qui lui était parfois peu, voire pas du tout favorable, le mouvement animaliste a pu percevoir des opportunités, s’en saisir et les faire perdurer dans le temps.
Importações orientais de época romana-republicana em Monte Molião (Lagos, Portugal)
Authors: De Sousa Elisa , Gomes Francisco B. , Arruda Ana Margarida , Pereira Carlos 
Published: July 2022

[pt] As intervenções arqueológicas realizadas no Monte Molião (Lagos, Portugal) proporcionaram um pequeno conjunto de materiais importados do Mediterrâneo Oriental. Trata-se, concretamente, de taças helenísticas com decoração a molde e de terra sigillata oriental A, que totalizam 18 fragmentos. Na maioria dos casos, estes exemplares surgem em contextos conservados de cronologia romano-republicana, especificamente entre 125 e 50/25 a. C., revelando a adopção de tradições helenísticas relacionadas com o consumo de líquidos e talvez até a existência de uma particular procura de vasos esteticamente mais apelativos. Apesar de ser um conjunto quantitativamente diminuto, assume uma particular relevância para o alargamento e compreensão da escala de distribuição destes produtos no litoral atlântico.
Plug it, fill it and forget it!
Authors: Arpitha R , Ramanjulu Rajesh , Shanmugam Mahesh P 
Published: July 2022

Background:
Management of posterior scleral perforation is commonly done with cryotherapy/laser or scleral patch graft depending on the size of perforation. However, for large perforations, the availability of donor sclera is always an issue. To overcome this problem, we tried using absorbable gelatin sponge to plug the perforation as an alternative.

Purpose:
To evaluate the efficacy of gelatin foam as an alternative to scleral patch graft in cases with perforation of posterior sclera.

Synopsis:
Here we report the case of a 27-year-old male, who sustained penetrating injury to right eye with two metallic intraocular foreign bodies with visual acuity of hand movement close to face. Primary wound repair was done, followed by retrieval of the first piece of metallic foreign body that measured 11X3mm in size. The second foreign body visualized at posterior pole adjascent to the disc was removed using Machemar forceps and it measured 10X3 mmin size. Leakage of PFCL at the site confirmed a posterior scleral perforation. Cryotherapy was avoided due to its proximity to optic nerve head, and donor sclera was not readily available at that moment. We managed the case by plugging the defect with absorbable gelatin foam, followed by silicone oil injection into the vitreous cavity. Post operative outcome was good with restoration of anatomical integrity of the globe along with improvement in visual acuity upto 6/18.

Highlights:
Gelatin foam being absorbable and inciting less reaction aids in sealing the perforation and maintenance of globe contour with the advantage being readily available, cost-effective and it can be left in situ without the need for additional surgery for its removal. This would be of use in situations where the donor sclera is not readily available, and thus can be a potential alternative. However, further studies with larger sample size need to be done to evaluate and compare its effectiveness over donor scleral grafts.

Online Video Link:

https://youtu.be/fkardnkMQQo
Consanguinity and ocular disorders in India: Electronic medical records driven big data analytics
Authors: Rauniyar Divya , Das Anthony Vipin 
Published: July 2022

Purpose:
To describe the distribution of ocular disorders in patients with a family history of consanguinity presenting to a multi-tier ophthalmology hospital network in India.

Methods:
This cross-sectional hospital-based study included 2,805,267 new patients presenting between August 2010 and April 2021. Patients with a family history of consanguinity were included as cases. The sociodemographic and clinical data were collected using an electronic medical record system.

Results:
Overall, 20,445 (0.73%) new patients were documented to have a family history of consanguinity. The prevalence rates were 4.04% in children (age: <16 years) and 0.21% in adults. The mean age of the patients was 11.87 ± 11.06 years. The majority of the patients were males (56.48%) and students (54.43%) by profession. The majority (93.05%) of the patients were in the 0–30-years age bracket, with over half of them (53.71%) presenting in the first decade of life. A significant number of patients were from higher socioeconomic status (73.48%) and the rural region (47.62%). The most common degree of consanguinity documented was second degree (3.95%). The most common ocular disorders associated with a high proportion of consanguinity were congenital hereditary endothelial dystrophy (CHED) (100%), corneal macular dystrophy (83.78%), xeroderma pigmentosum (80.95%), and ocular albinism (73.59%). A tenth of the patients (9.8%) reported a similar history of ocular disorders among the family members and more commonly among the siblings (70.4%).

Conclusion:
Consanguineous marriages are not uncommon in India. They cause ocular disorders that cause visual impairment in a significant majority of those affected in their early decades of life. Genetic counseling plays a role in prevention.
Cross-sectional observational analysis of the genetic referral practices across pediatric ophthalmology outpatient departments in an urban setting
Authors: Bajaj Shruti , Venkatraman Mathangi , Agarwal Nidhi , Kothari Mihir 
Published: July 2022

Purpose:
To analyze the genetic referral practices of pediatric ophthalmologists in an urban setting.

Methods:
(1) The first limb of the study: cross-sectional, observational study among children visiting the outpatient department of pediatric ophthalmology across five centers in Mumbai. All pediatric patients were screened separately by pediatric ophthalmologists and a clinical geneticist for their ophthalmic and systemic complaints. Children were marked for referral to genetics (RTG) by both the specialists based on identification of distinctive features (red flag) and were requested to meet a local geneticist. (2a) Twenty-three months later, patients who had been marked for RTG were contacted telephonically to follow-up if they had met the geneticist. (2b) Additionally, the last 20 proformas from each center were checked retrospectively to note the RTG marked by the ophthalmologist alone.

Results:
(1) In the first aspect of the study, 126 patients (male: female = 1.2:1) were included. Forty-nine (38.3%) patients were referred for genetic evaluation, of which three (6.1%), 31 (63.26%), and 15 (30.6%) cases were referred by the ophthalmologist alone, geneticist alone, and by both the specialists, respectively. Glaucoma (100%), nystagmus (86%), and leukocoria (83%) were the most prominent ocular diagnoses in cases referred for genetic evaluation. Facial dysmorphism (55.1%) and neurodevelopmental delays (51%) were among the most common systemic red flags found in patients referred to genetics. (2a) Twenty-three months later, on contacting the 49 patients marked for RTG, only one family had met the geneticist. (2b) Retrospective evaluation of 100 proformas: only three patients were marked for RTG by ophthalmologist alone.

Conclusion:
This study found that the genetic referrals by pediatric ophthalmologist were far lesser than those by geneticist. The study highlights an area of knowledge gap among pediatric ophthalmologists, prompting a need for heightened awareness in this area.
Clinical features and orbital anomalies in Fraser syndrome and a review of management options
Authors: Das Deepsekhar , Modaboyina Sujeeth , Raj Sandton , Agrawal Sahil , Bajaj Mandeep Singh 
Published: July 2022

Purpose:
Fraser syndrome is a rare congenital disorder comprising cryptophthalmos, syndactyly, and many times, urogenital anomalies. Herein, the authors aimed to study and report the clinical features and orbital anomalies in cases diagnosed with Fraser syndrome.

Methods:
The authors retrospectively evaluated the records of patients with Fraser syndrome who had presented to a tertiary eye care hospital in northern India in the last 2 years (from January 2019 to December 2020). The clinical features were studied, entered in MS Excel, and the data was evaluated.

Results:
Data of 15 patients with Fraser syndrome were found. Majority of the patients were males and presented in the pediatric age group. Bilateral involvement was more common, and the most common variant of cryptophthalmos was abortive. Complete and medial madarosis of the eyebrows was the most common periocular finding. Complete cryptophthalmos was associated with cystic globes, whereas abortive forms had superior symblepharon. Common systemic features included syndactyly, bifid nose, and urogenital anomaly.

Conclusion:
Fraser syndrome is an extremely rare developmental disorder; it encompasses a wide range of ocular, periocular, and orbital anomalies, along with multiple pre-existing systemic anomalies. The treating ophthalmologist should always be careful in examining these patients