bluuebunny/crossref_metadata_2025_split huggingface dataset:
LLMs meet the AI Act: Who’s the sorcerer’s apprentice?
Authors: Pagallo Ugo 
Published: January 2025

Abstract
The paper examines the legal regulation and governance of “generative artificial intelligence” (AI), “foundation AI,” “large language models” (LLMs), and the “general-purpose” AI models of the AI Act. Attention is drawn to two potential sorcerer’s apprentices, namely, in the spirit of J. W. Goethe’s poem, people who were unable to control a situation they created. Focus is on developers and producers of technologies, such as LLMs that bring about risks of discrimination and information hazards, malicious uses and environmental harms; furthermore, the analysis dwells on the normative attempt of European Union legislators to govern misuses and overuses of LLMs with the AI Act. Scholars, private companies, and organisations have stressed limits of such normative attempt. In addition to issues of competitiveness and legal certainty, bureaucratic burdens and standard development, the threat is the over-frequent revision of the law to tackle advancements of technology. The paper illustrates this threat since the inception of the AI Act and recommends some ways in which the law has not to be continuously amended to address the challenges of technological innovation.
Mapping Generative AI rules and liability scenarios in the AI Act, and in the proposed EU liability rules for AI liability
Authors: Rodríguez de Las Heras Ballell Teresa 
Published: January 2025

Abstract
The Paper aims to explore whether the current ecosystem of existing and still-to-be adopted rules on artificial intelligence (AI) systems in the European Union does fully and adequately address the liability for damages caused by Generative AI system. It maps first and primarily the distinctive features and functional characteristics of Generative AI likely to impact on regulatory and legal considerations and, in particular, on determining the specific regulatory regime governing Generative AI and on tracing and allocating liability along the value chain pursuant to the AI Act. On the basis of this mapping exercise, the Paper focuses on testing the liability rules as provided for the draft Artificial Intelligence Liability Directive and the Revised Product Liability Directive and assessing their sufficiency and effectiveness in the face of Generative AI. Beyond the assessment of the rules laid down in the above-referred texts, the Paper briefly describes other liability scenarios to be explored in future works.
Tailoring coherent beam combined laser pulse trains for high peak and average power applications
Authors: Ranély-Vergé-Dépré Claude-Alban , Lechevalier Corentin , Andrieu Jordan , Fsaifes Ihsan , Jovanovic Igor , Chanteloup Jean-Christophe 
Published: January 2025

Abstract
Laser systems based on coherent beam combination (CBC) that rely on tiled pupil architecture intrinsically carry digital capabilities independently applicable to all three essential characteristics of a laser pulse: amplitude, phase and polarization. Those capabilities allow the far-field energy distribution to be flexibly tailored in real time. Operation in the femtosecond regime at high repetition rates gives access to a wide range of applications requiring both high peak and average powers. We address the task of independent peak versus average power adjustment needed for applications seeking to decouple nonlinear phenomena associated with GW peak power from the thermal load inherent to kW average power operation. The technical solutions proposed are presented in the framework of the Ecole Polytechnique XCAN CBC laser platform (61 independent channels) with an emphasis on thermal management measures implemented to ensure its nominal operation.
Watt-level sub-100 fs third near-infrared window laser generated by self-seeded coherent Raman amplification based on erbium-ytterbium co-doped fiber
Authors: Zhang Jiaxuan , Fan Jintao , Hu Minglie 
Published: January 2025

Abstract
In this paper, we prove that the third near-infrared (NIR-III) window high-power laser with wavelength in the range of 1600–1800 nm can be obtained by the coherent Raman fiber amplification technique through theoretical and experimental study. Detailed numerical simulation reveals that the nonlinear dynamics of the Raman fiber amplification in the polarization-maintaining double-clad erbium-ytterbium co-doped fiber is similar to that of the Mamyshev oscillator. Through the spectral filtering effect induced by finite Raman gain, we can obtain a high-quality Raman pulse. According to the theoretical results, we design a simple Raman fiber amplification laser and finally obtain a high-quality watt-level NIR-III window laser pulse in which the central wavelength is about 1650 nm and the pulse width can reach 85 fs. The experimental results correspond to the simulation results. Such nonlinear effect is universal in all kinds of fibers, and we think this technology can provide a great contribution to the development of ultrafast fiber lasers.
High-efficiency thin-plate compression of multi-TW Ti:sapphire lasers
Authors: Li Zhaoli , Zhou Kainan , Mu Jie , Wang Xiaodong , Zeng Xiaoming , Wu Zhaohui , Wang Xiao , Zuo Yanlei 
Published: January 2025

Abstract
Nonlinear compression experiments based on multiple solid thin plates are conducted in an ultra-high peak power Ti:sapphire laser system. The incident laser pulse, with an energy of 80 mJ and a pulse width of 30.2 fs, is compressed to 10.1 fs by a thin-plate based nonlinear compression. Significant small-scale self-focusing is observed as ring structures appear in the near-field of the output pulse at high energy. Numerical simulations based on the experimental setup provide a good explanation for the observed phenomena, offering quantitative predictions of the spectrum, pulse width, dispersion and near- and far-field distributions of the compressed laser pulse.
The Ability and Authority of Servants in a Ming Lineage Plan
Authors: Schneewind Sarah 
Published: January 2025

Abstract
In considering Huo Tao’s Family Admonitions, a text included in a lineage genealogy of the early sixteenth century, this article investigates its five constituent logics (Confucian propriety, bureaucratic division of responsibility, subsistence agriculture, wealth creation, and punitive patriarchy). It explains what sorts of expert abilities Huo considered necessary and what relations of authority (defined as power over others that they accept) those abilities entailed. Huo’s plan relies not only on the expertise of lineage members, but also on the abilities of hired workers and bondservants/slaves who held their positions for a long time. Their positions gave them authority in the workspace over the lineage members who outranked them legally, calling into question the utility of simple categories of “social status.” Because the text was later copied repeatedly into other lineages’ compilations, Huo’s plan must have made sense to Ming and Qing lineage leaders, so it may illuminate how they constructed relations of authority and social status.
A Victorian nature cure philosophy as a reconciliation of Romantic Naturalism and laboratory medicine: the case of E.W. Lane’s (1823–89) hygienic medicine
Authors: Bae Min 
Published: January 2025

Abstract
This article primarily concentrates on the theoretical and intellectual dimensions of nature cure, particularly efforts to revive it during the second half of the nineteenth century. Little is known about specific medical professionals or theories concerning the Victorian philosophy of nature cure, although this philosophy is mentioned in general terms in studies on alternative medicine and hygiene. This article illuminates a Victorian nature cure philosophy through the works of Edward W. Lane (1823–1889). As a physician and hydropathist, Lane aspired to create a new form of medical system, ‘hygienic medicine’, seeking answers to the questions ‘What is disease?’ and ‘What is medicine?’ throughout his career. Lane was among many physicians interested in nature’s healing power during his time. However, few undertook as thorough a theorisation of nature cure philosophy as Lane did in the latter half of the nineteenth century, a period that presented unprecedented challenges in reconciling medicine with nature. This study explores the subtle nuances of the concepts that Lane actively used in his theoretical explanations, including ‘nature’, ‘laws of health’ and ‘vital force’, interpreting his efforts as a reconciliation between Romantic naturalism and laboratory medicine. The aim of this study is not to re-evaluate the significance of Lane’s medical theory itself. It rather uses Lane as a lens to reveal the intricacies of Victorian nature cure philosophy.
Interactions among simultaneous elections
Authors: Zhou Congyi 
Published: January 2025

Abstract
In this study, we examine the interactions among elections by considering two parties competing in simultaneous elections, where each party fields candidates in every election. We model these interactions through voters’ utility functions, influenced not just by the policies proposed in a specific election but also by those in concurrent elections. The benchmark result indicates that all candidates adopt positions more polarized than those predicted by the Calvert–Wittman model. This shift occurs because candidates leverage the policy stance of their counterparts in co-partisan elections to pursue policies more aligned with their preferences. In multidistrict elections, candidates from areas with strong ideological leanings deviate further from the median voter's stance at the national level. Moreover, this interaction effect may select candidates with more extreme ideology into the local elections.
Reward or punishment? The distribution of life-cycle returns to political office
Authors: Dahlgaard Jens Olav , Kjøller Frederik K. , Kristensen Nicolai 
Published: January 2025

Abstract
The remuneration of MPs affects who engages in politics. Even if average returns to office are positive, as found in all other studies, some officeholders’ returns are likely negative. Further, the timing of returns to office is crucial as politicians often enjoy delayed compensation like lucrative pensions. Utilizing administrative data for parliamentary candidates in Denmark from 1994 to 2015, we estimate first-time runners’ earnings and total income returns to office. Based on total income, practically all elected MPs experience economic gains during their first term. Computations of life-cycle returns reveal that the 25 percent highest earning candidates (pre-office) have no long-term economic gain from winning. Generally, considering the distribution and timing of returns to office improves studies of how office-holding is economically rewarded.
Competent legislators or mere pawns? Experimental evidence of attitudes toward gender quota politicians
Authors: Barnett Carolyn , Blackman Alexandra , Shalaby Marwa 
Published: January 2025

Abstract
Do citizens evaluate quota and non-quota politicians similarly? Do voters perceive quota-elected politicians as less competent and autonomous? Despite the proliferation of gender quotas, it remains unclear how citizens view female quota politicians compared to their non-quota male and female counterparts. This is particularly important in electoral systems where competitive and reserved seats both exist. We conducted a vignette experiment in Morocco where we randomized information about how politicians were elected and their legislative behavior. We find no evidence that voters evaluate quota women as less competent than non-quota male and female politicians. Our data demonstrate partial support for the argument that quota women are perceived as pawns of their parties, although information about legislative behavior can mitigate this perception.
Detailed characterisation of the Co-Smad protein in liver fluke Fasciola gigantica
Authors: Japa O. , Phuangsri C. , Klinbumrung K. , Prakhammin K. , Flynn R. J. 
Published: January 2025

Abstract
Fasciolosis, caused by the liver flukes Fasciola hepatica and Fasciola gigantica, is a zoonotic parasitic disease associated with substantial economic losses in livestock. The transforming growth factor-beta signalling pathway is implicated in developmental processes and biological functions throughout the animal kingdom, including the Fasciola spp. It may also mediate host–helminth interactions during infection. In this work, we present an exploration of FgSmad4, the sole member of the Co-Smad protein family in F. gigantica. The isolated FgSmad4 cDNA was 4,014 bp in length encoding for a protein comprising 771 amino acids. FgSmad4 exhibited typical Co-Smad protein features, including Mad Homology 1 (MH1) and Mad Homology 2 (MH2) domains, a Nuclear Localisation Signal, a DNA-Binding Motif, and a Nuclear Export Signal. Sequence and phylogenetic analyses of FgSmad4 revealed that its MH1 and MH2 sequences are most similar to those of other trematode species. The MH1 domain, in particular, closely resembles the Co-Smad protein in mammalian hosts more than those in cestodes and nematodes. The expression patterns of FgSmad4 during the liver fluke’s developmental stages showed significant variation. Transcript levels were highest at the newly excysted juvenile stage, followed by unembryonated egg, redia, and metacercaria, with the lowest expression in the adult fluke, embryonated egg, and cercaria stages. Our results underscore the conservation and suggest the potential role of FgSmad4, a key transforming growth factor-beta signalling molecule within the liver fluke F. gigantica. As Co-Smad is typically involved in several biological pathways, the precise functions and mechanisms of this identified FgSmad4 necessitate further exploration.
Good Practices for Health Technology Assessment Guideline Development: A Report of the Health Technology Assessment International, HTAsiaLink, and ISPOR Special Task Force
Authors: Botwright Siobhan , Sittimart Manit , Chavarina Kinanti Khansa , Bayani Diana Beatriz Samson , Merlin Tracy , Surgey Gavin , Suharlim Christian , Espinoza Manuel A. , Culyer Anthony J. , Oortwijn Wija , Teerawattananon Yot 
Published: January 2025

Abstract

Objectives
Health technology assessment (HTA) guidelines are intended to support the successful implementation of HTA by enhancing consistency and transparency in concepts, methods, processes, and use, thereby enhancing the legitimacy of the decision-making process. This report lays out good practices and practical recommendations for developing or updating HTA guidelines to ensure successful implementation.

Methods
The task force was established in 2022 and comprised experts and academics from various geographical regions, each with substantial experience in developing HTA guidelines for national health policy making. Literature reviews and key informant interviews were conducted to inform these good practices. Stakeholder consultations, open peer reviews, and expert opinions validated the recommendations. A series of teleconferences among task force members was held to iteratively refine the report.

Results
The recommendations cover six key aspects throughout the guideline development cycle: (1) setting objectives, scope, and principles of the guideline, (2) building a team for a quality guideline, (3) defining a stakeholder engagement plan, (4) developing content and utilizing available resources, (5) putting in place appropriate institutional arrangements, and (6) monitoring and evaluating guideline success.

Conclusion
This report presents a set of resources and context-appropriate practices for developing or updating HTA guidelines. Across all contexts, the recommendations emphasize transparency, building trust among stakeholders, and fostering a culture of ongoing learning and improvement. The report recommends timing development and revision of guidelines according to the HTA landscape and pace of HTA institutionalization. Because HTA is increasingly used to inform different kinds of decision making in a variety of country contexts, it will be important to continue to monitor lessons learned to ensure the recommendations remain relevant and effective.
Surge of human astrovirus type 1 infection in summer 2022 in Korea
Authors: Lee Su-Kyung , Jeon You La , Cho Eun-Jung , Kim Han-Sung , Kim Jae-Seok , Song Wonkeun , Kim Hyun Soo 
Published: January 2025

Abstract
As astroviral infection rapidly increased in the summer of 2022 in Korea, this study aimed to determine the cause and genotype of astroviruses during this period. From January to December 2022, we tested 43,312 stool samples from patients with acute gastroenteritis utilizing multiplex PCR to detect HAstV. For the HAstV-positive samples, we determined the genotypes of the HAstVs by PCR and sequencing. The monthly positive rate from 2015 to 2022 showed a notable and abrupt increase of HAstV infection between June and August 2022, peaking at 9.8% in July 2022. The annual positivity rate of HAstV remained at 2–3% between 2015 and 2019, and then decreased to 0.5% in 2020, followed by an increase to 1.5% in 2021 and 3.6% in 2022.The genotyped astroviruses in 2022 were all identified as HAstV-1 type, and the nucleotide identity% among them was >99%. The GenBank accession number for the strain genetically closest to the strains identified in our study was ON571597.1, which was HAstV-1 isolated from Pingtan in 2019. Our results provide recent epidemiological data on HAstVs in Korea. The decline and surge in astrovirus positivity in recent years may be related to the COVID-19 pandemic.
Effects of maternal liver abnormality on in vitro maturation of bovine oocytes
Authors: Ashibe Shiori , Kobayashi Yui , Toishikawa Shusuke , Nagao Yoshikazu 
Published: January 2025

Summary
In cattle, maternal metabolic health has been suggested to influence oocyte and embryo quality. Here, we examined whether maternal liver abnormalities affected in vitro oocyte maturation by screening meiotic maturation, spindle morphology, actin filaments, and lysosomes. In oocytes from the abnormal liver group, the maturation rate (80.2%) was significantly lower compared to a control group with healthy livers (90.8%; P < 0.05). Mean spindle area in oocytes of the abnormal group (50.4 ± 3.4 μm2) was significantly larger than in the control (40.8 ± 1.6 μm2; P < 0.05). Likewise, mean spindle width in the abnormal group (8.8 ± 0.3 μm) was significantly larger than in the control group (7.8 ± 0.2 μm; P < 0.05). The proportion of cells with correctly aligned chromosomes in the abnormal group (48.0%) was significantly lower than in the control (78.3%; P < 0.05). The number of cortical actin filaments in mature oocytes of the abnormal group (299.3 ± 3.7) was significantly lower than in the control (314.7 ± 3.2; P < 0.05). The number of lysosomes in mature oocytes of the abnormal group (1363.6 ± 39.0) was significantly higher than in the control (1123.4 ± 26.3; P < 0.05). In conclusion, our findings indicate that the quality of in vitro matured oocytes is lower in cattle with liver abnormalities than in healthy cattle.
The effect of consecutive ejaculation on the sperm parameters in the oligo-astheno-teratozoospermia (OAT) men
Authors: Hosseini Akram , Borzouie Zahra , Khalili Parvin , Vatanparast Mahboubeh 
Published: January 2025

Summary
Recently, the World Health Organization recommendation for abstinence time for semen analysis has been challenged in some studies and many of them have supported the advantages of a second short abstinence ejaculation. More evidence is needed to approve this for clinical use. This study aimed to compare the average routine abstinence time (2–7 days) with the short time (1–2 h) on sperm quality based on functional parameters in a population of oligo-astheno-teratozoospermia (OAT) men. The semen samples were retrieved from 50 men with OAT two times: one standard 2–7 days (long ejaculation) and short duration trimming (1–2 hours later the first ejaculation). All semen parameters as well as sperm DNA integrity were compared between groups. Results showed that mean sperm concentration (10.40 vs. 8.76), total sperm count (28.53 vs. 12.24) and mean semen volume (2.69 vs. 1.40) were higher in the first ejaculation (2–7 days of abstinence), while progressive motility (20.52 vs. 13.32), non-progressive motility (53.46 vs. 48.86), morphology (2.46 vs. 1.46) and viability (83.90 vs. 77.96) were significantly higher in the second ejaculation (P < 0.05). The second sample also showed lower immotile (26.82 vs. 38.02) and DNA fragmentation (19.5 vs. 26.96) (P < 0.05). Taking all data into account, an additional short abstinence period (AP) may be a simple and helpful strategy to obtain better sperm quality in couples with male infertility causes, especially in OAT patients. The recommended current guidelines regarding the AP may need to be revisited in severe male factors.
Novel use of trametinib for treatment of atrial arrhythmia in absence of cardiomyopathy in a patient with Costello syndrome
Authors: Kato Andrew S. , Shwaish Natalie S. , Hwang Eugene Y. , Mandapati Ravi , Lee Jesse W. 
Published: January 2025

AbstractWe describe a case of novel use of trametinib in treating arrythmia without concomitant cardiomyopathy. Our patient is a two-year-old female born with Costello syndrome due to heterozygous mutations in the HRAS gene c34 G > T p (G12C). Shortly after birth, she was diagnosed with multifocal atrial tachyarrhythmia. Her imaging studies have shown no hypertrophy or CHD. There was poor arrhythmia control despite triple antiarrhythmic therapy. Trametinib, a MEK1 and MEK2 inhibitor, was used in treating her isolated atrial arrythmia, allowing her to wean off other antiarrhythmics. Other case reports have shown trametinib to benefit certain RASopathy patients with lymphatic abnormalities, hypertrophic cardiomyopathy, and concurrent arrhythmias. This case demonstrates effective treatment of isolated arrhythmia without cardiomyopathy, broadening the potential indications for use of trametinib in certain RASopathy patients.
Immigration is difficult?! Informing voters about immigration policy fosters pro-immigration views
Authors: Kustov Alexander , Landgrave Michelangelo 
Published: January 2025

Abstract
The US public is mostly ignorant about basic immigration knowledge. While various attempts to correct misperceptions have generally failed to change people’s minds about the issue, it is possible that this failure has been the result of not providing relevant information. We argue that informing the public about the difficulty of the legal immigration admission process is an effective, perspective-changing way to raise support for more open immigration policies. We test and confirm this hypothesis using a nationally representative US survey experiment (N = 1000) that informs respondents about US immigration’s administrative burdens and restrictions through short verifiable narratives. We also provide the first evidence of the widespread ignorance about the immigration process across diverse political and demographic groups. Our results suggest that providing a better understanding of the immigration process’ difficulty has more promise to change public policy preferences than challenging skeptics’ crystallized beliefs about immigration’s effects or numbers.