bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIM Structural Project Applied in A Case Study: Interoperability Analyses, Reinforcement Detailing Drawings and Quantity Take-off
Authors: Sampaio Alcinia Z. , Gomes Augusto M. 
Published: January 2022

Background:
The Building Information Modelling (BIM) methodology has been acquiring, worldwide, a growing acceptance in all sectors of the Construction industry, and the study intends to contribute to its implementation within the structural design. The fundamental concept of BIM is based on the generation of a centralized virtual model with all information concerning different specialties. This is supported in efficient interoperability, but within the structural design, this aspect is difficult to achieve completely, as currently, the interoperability of this system is still inefficient.

Introduction:
This study intends to analyze the degree of interoperability verified in the development of all the processes (modelling, transposition, structural analyses and reinforcement detailing) involved in a structural design using BIM tools.

Methods:
A structural project concerning a study case was performed in order to identify benefits and limitations, based on the consistency analysis of the transposed data between systems, Revit and Robot, in all steps required in a BIM process. This text describes the stages of modelling, checking the suitability of the analytical model, its transference to the analysis tool in order to proceed with the structural calculations and detailing drawings and, finally, the transfer of drawings to the main BIM model.

Results:
The limitations verified in the last stage were partially surpassed with complementary work enabling the automatic transfer of drawings and quantities of materials. In addition, the study explores new capacities of BIM, namely, the extraction of information allowing the presentation of specific drawings and maps of the geometry of the reinforcement rods.

Conclusion:
This study identifies a working strategy that leads to an appropriate use of BIM software contributing to the optimization of labor in a structural office.
Design, Fabrication and Characterization of Nanoliposomes Containing Snake Venom ofPseudocerastes persicus
Authors: Emami Tara , Nazari Ali , Jaafari Mahmoudreza , Madani Rasool , Golchinfar Fariba , Dounighi Nasser Mouhammadpour , Samianifard Maedeh 
Published: January 2022

Background:The development of antivenom or antidote requires the repetition of immunization of large animals, such as horses and goats, which ultimately releases the IgG immunoglobulin produced in the serum specimen. As snake venom involves a variety of proteins and enzymes getting administered into the animal, this process can inflict significant harm to the animal; therefore, choosing carriers that can deliver the least amount of venom could be a safer option for animal immunization.Objective:In this research, nanoliposomes were used to encapsulate venom as a protected cargo for immunization. We used two distinct liposomal formulations to entrap the venom: 1,2-distearoyl- sn-glycero-3-phosphocholine, 1,2-distearoyl-sn-glycero-3-phospho-(1′-rac-glycerol) associated with cholesterol in one formulation and dimethyldioctadecylamonium (Bromide salt) paired with cholesterol in the other.Method:Liposomal formulations were prepared by a solvent evaporation method, and the venom was encapsulated in liposomes and evaluated for size and zeta potential. Meanwhile, encapsulation efficiency, venom release percentage, and phospholipase activity have all been analyzed.Results:The findings revealed that dimethyldioctadecylamonium (Bromide salt) combined with cholesterol had the highest encapsulation efficiency. In this formulation, the venom release rate had a steady-state profile. The lack of phospholipase activity in this formulation may be due to a bromide group in the liposomal structure that could be useful for immunization.Conclusion:Liposomal formulations, which do not have the active site of the snake venom enzymes, could be used for venom encapsulation.
Organoids as Ex Vivo Culture System to Investigate Infection-host Interaction in Gastric Pre-carcinogenesis
Authors: Di Giorgio Cristina , Roselli Rosalinda , Biagioli Michele , Marchianò Silvia , Distrutti Eleonora , Bordoni Martina , Donini Annibale , Fiorucci Stefano 
Published: January 2022

Abstract:
Advancements in stem cell research have enabled the establishment of three-dimensional (3D) primary cell cultures, known as organoids. These culture systems follow the organization of an in vivo organ, as they enclose the different epithelial cell lines of which it is normally composed. Generation of these 3D cultures has bridged the gap between in vitro models, made up by two-dimensional (2D) cancer cell lines cultures, and in vivo animal models, that have major differences with human diseases. Organoids are increasingly used as a model to study colonization of gastric mucosa by infectious agents and to better understand host-microbe interactions and the molecular events that lead to infection, pathogen-epithelial cells interactions and mechanisms of gastric mucosal injury. In this review we will focus on the role of organoids as a tool to investigate molecular interactions of Helicobacter (H.) pylori and Epstein Barr Virus (EBV) and gastric mucosa and how these infections, that affect ≈ 45% of the world population, might progress to gastric cancer, a highly prevalent cancer and the third leading cause of cancer death.
Personalization of Intervention Timing for Physical Activity: Scoping Review
Authors: Chaudhari Saurabh , Ghanvatkar Suparna , Kankanhalli Atreyi 
Published: January 2022

Background
The use of sensors in smartphones, smartwatches, and wearable devices has facilitated the personalization of interventions to increase users’ physical activity (PA). Recent research has focused on evaluating the effects of personalized interventions in improving PA among users. However, it is critical to deliver the intervention at an appropriate time to each user to increase the likelihood of adoption of the intervention. Earlier review studies have not focused on the personalization of intervention timing for increasing PA.

Objective
This review aims to examine studies of information technology–based PA interventions with personalized intervention timing (PIT); identify inputs (eg, user location) used by the system for generating the PIT, the techniques and methods used for generating the PIT, the content of the PA intervention, and delivery mode of the intervention; and identify gaps in existing literature and suggest future research directions.

Methods
A scoping review was undertaken using PsycINFO, PubMed, Scopus, and Web of Science databases based on a structured search query. The main inclusion criteria were as follows: the study aimed to promote PA, included some form of PIT, and used some form of information technology for delivery of the intervention to the user. If deemed relevant, articles were included in this review after removing duplicates and examining the title, abstract, and full text of the shortlisted articles.

Results
The literature search resulted in 18 eligible studies. In this review, 72% (13/18) of the studies focused on increasing PA as the primary objective, whereas it was the secondary focus in the remaining studies. The inputs used to generate the PIT were categorized as user preference, activity level, schedule, location, and predicted patterns. On the basis of the intervention technique, studies were classified as manual, semiautomated, or automated. Of these, the automated interventions were either knowledge based (based on rules or guidelines) or data driven. Of the 18 studies, only 6 (33%) evaluated the effectiveness of the intervention and reported positive outcomes.

Conclusions
This work reviewed studies on PIT for PA interventions and identified several aspects of the interventions, that is, inputs, techniques, contents, and delivery mode. The reviewed studies evaluated PIT in conjunction with other personalization approaches such as activity recommendation, with no study evaluating the effectiveness of PIT alone. On the basis of the findings, several important directions for future research are also highlighted in this review.
The Use of Cremation Data for Timely Mortality Surveillance During the COVID-19 Pandemic in Ontario, Canada: Validation Study
Authors: Postill Gemma , Murray Regan , Wilton Andrew S , Wells Richard A , Sirbu Renee , Daley Mark J , Rosella Laura 
Published: January 2022

Background
Early estimates of excess mortality are crucial for understanding the impact of COVID-19. However, there is a lag of several months in the reporting of vital statistics mortality data for many jurisdictions, including across Canada. In Ontario, a Canadian province, certification by a coroner is required before cremation can occur, creating real-time mortality data that encompasses the majority of deaths within the province.

Objective
This study aimed to validate the use of cremation data as a timely surveillance tool for all-cause mortality during a public health emergency in a jurisdiction with delays in vital statistics data. Specifically, this study aimed to validate this surveillance tool by determining the stability, timeliness, and robustness of its real-time estimation of all-cause mortality.

Methods
Cremation records from January 2020 until April 2021 were compared to the historical records from 2017 to 2019, grouped according to week, age, sex, and whether COVID-19 was the cause of death. Cremation data were compared to Ontario’s provisional vital statistics mortality data released by Statistics Canada. The 2020 and 2021 records were then compared to previous years (2017-2019) to determine whether there was excess mortality within various age groups and whether deaths attributed to COVID-19 accounted for the entirety of the excess mortality.

Results
Between 2017 and 2019, cremations were performed for 67.4% (95% CI 67.3%-67.5%) of deaths. The proportion of cremated deaths remained stable throughout 2020, even within age and sex categories. Cremation records are 99% complete within 3 weeks of the date of death, which precedes the compilation of vital statistics data by several months. Consequently, during the first wave (from April to June 2020), cremation records detected a 16.9% increase (95% CI 14.6%-19.3%) in all-cause mortality, a finding that was confirmed several months later with cremation data.

Conclusions
The percentage of Ontarians cremated and the completion of cremation data several months before vital statistics did not change meaningfully during the COVID-19 pandemic period, establishing that the pandemic did not significantly alter cremation practices. Cremation data can be used to accurately estimate all-cause mortality in near real-time, particularly when real-time mortality estimates are needed to inform policy decisions for public health measures. The accuracy of this excess mortality estimation was confirmed by comparing it with official vital statistics data. These findings demonstrate the utility of cremation data as a complementary data source for timely mortality information during public health emergencies.
Inferior ST-Segment Elevation Myocardial Infarction with First-Degree Atrioventricular Block: A Case Report and Literature Review
Authors: Pradana Aditya Doni , Widodo Jarot 
Published: January 2022

Background: Atrioventricular (AV) block complicating acute inferior wall ST-elevation myocardial infarction (STEMI) is known to be associated with poor outcomes and increased rate of mortality.
Case Report: We present the case of a 69-year old male patient, an active smoker, presented to the emergency department due to syncope 2 hours prior to admission. He reported symptoms while farming with sudden onset of diaphoresis, mild dizziness, and breathlessness followed by loss of consciousness for several minutes. Blood pressure was 79/55 mmHg, respiratory rate was 23, pulse was 46 bpm. Electrocardiogram showed inferior wall STEMI with first-degree AV block. Laboratory data revealed a significantly marked increase of CK-MB 82,5 U/L. STEMI protocol and fibrinolytic therapy has been done. The mechanisms of AV block and its spontaneous resolution in the setting of acute inferior wall STEMI are discussed. Attention is drawn to the patient due to our hospital categorized as an incapable cath lab sub-district hospital.
Discussion: Clinical signs and examination suggested that this patient had a first-degree AV block complicating inferior wall STEMI on admission and fulfill the criteria of successful reperfusion 30 minutes following fibrinolytic therapy. Immediately after fibrinolysis, breathlessness was relieved, ST-T segment was reduced, spontaneous resolution of first-degree AV block occurred, and absence of Q-wave formation.
Conclusion: Immediate reperfusion therapy is the core management of STEMI patients, including fibrinolytic therapy. Signs of successful therapy could be seen in this case and also relieved of the complication associated with STEMI. We found it as an incidence not much reported and thus reporting the case herewith.
Correlation between Global Longitudinal Strain and Ischemic Burden from Myocardial Perfusion Imaging in Multivessel Coronary Artery Disease Patients
Authors: Apriza Rian , Hasan Harris , Nasution Ali Nafiah 
Published: January 2022

Background: Global Longitudinal Strain (GLS) is a direct echocardiographic assessment of myocardial fiber deformation performed by speckle-tracking echocardiography that can better reflect ischemic and infarct areas and left ventricular function. Ischemic burden is a measurement of ischemic myocardium percentage and can be used to determine the management strategy of Multivessel Coronary Artery Disease (MVCAD). We aimed to investigate the value of GLS to predict the ischemic burden as detected by SPECT Myocardial Perfusion Imaging (MPI)
Method: A cross-sectional study of patients with Multivessel Coronary Artery Disease who underwent Cardiac SPECT were included. GLS is assessed using the Automated Function Imaging (AFI) technique that is performed on the same day as the SPECT examination. Ischemic burden was measured by SPECT MPI using semi-quantitative scores on 17-segment assessment according to standard nomenclature and interpreted as small and moderate-large ischemic burden.
Result: Total of 52 patients (40 males, mean age 56 ± 6.5 years). There was negative correlation with good strength between GLS value and ischemic burden (r = -0.706, P < 0.001). Using ROC analysis, the optimal cut off value of GLS was < (-13%) that yielded the highest sensitivity and specificity to discriminate between small and moderate-large ischemic burden. Sensitivity, specificity, positive and negative predictive value of GLS ≤(-13%) to predict moderate-large ischemic burden as detected by SPECT analysis were 80%, 75%, 67%, and 86%, respectively.
Conclusion: A GLS value is a reliable parameter with good diagnostic value to predict small ischemic burden (<10%) as detected by SPECT MPI. This parameter could also be applied to determine the management strategy of Multivessel Coronary Artery Disease (MVCAD) patients in daily practice.
Terminal QRS Distortion on Admission ECG as a Predictor for Major Cardiovascular Adverse Events during Hospitalization in Patient with ST Segment Elevation Myocardial Infarction in Haji Adam Malik General Hospital
Authors: Ilyas Kamal Kharrazi , Safri Zainal , Hasan Harris , Mukhtar Zulfikri , Akbar Nizam Zikri , Sitepu Andika 
Published: January 2022

Background: Mortality in patient with acute myocardial infarction has decreased due to evolution in management system in patient with acute coronary syndrome, but mortality rate during hospitalization remains high, especially STEMI. Electrocardiography (ECG) has a role for diagnosing and predict prognosis in acute myocardial infarction. Terminal QRS distortion defined as J point elevation more than 50% of R wave in lead with qR configuration and/or loss of S wave with RS configuration. Changes of terminal QRS segment believed to be caused by electrical conduction elongation in Purkinje fiber or myocardial ischemic zone that represent severe ischemia. The purpose of this study is to assess the role of terminal QRS distortion as one of the parameter to predict major adverse cardiovascular events during hospitalization in ST elevation myocardial infarction in RSUP H. Adam Malik
Methods: This is a ambispective observational study consist of STEMI patients who were hospitalized from Mei 2019 to September 2019. All subjects diagnosed with STEMI and already fulfilled the inclusion and exclusion criterias. The terminal QRS distortion on the ECGs was assessed when the patient came to emergency departement. Then during hospitalization, the patients will undergo intervention and then observed during hospitalization for MACE occurrence.
Results: Of the 78 STEMI patients, 44 people had terminal QRS distortion and 34 did not have terminal QRS distortion. In group with terminal QRS distortion, 27 people experiences MACE. From the correlation analysis, there is positive correlation between terminal QRS distortion with MACE with correlation coefficient 0.317 (p value < 0.001). Multivariate analysis for most significant variable for MACE occurrence shows that terminal QRS distortion can predict MACE (OR 3.66 [1.317-10.166], 95% CI, p = 0.013)
Conclusion: Terminal QRS distortion found in ECG at admission in STEMI patient correlate with major adverse cardiovascular event during hospitalization.
Hemostatic Factors and Its Correlation with Outcomes of COVID-19 Confirmed Patients in Ulin Regional Hospital Banjarmasin
Authors: Rahmawaty Desi , Nadia Muslimah Annisa  , Haryati  
Published: January 2022

Background: Corona Virus Disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has become a Global Pandemic and has spread to more than 200 countries including Indonesia. Previous studies show that poor prognosis has a correlation with coagulopathy conditions.
Objectives: To identify coagulopathy condition and its correlation with the outcomes of COVID-19 confirmed patients at Ulin Regional Hospital Banjarmasin in the period March-August 2020.
Methods: A retrospective study by extracting laboratory data from medical record of 309 patients confirmed with COVID-19 at Ulin Regional Hospital Banjarmasin in the period March-August 2020.
Results: This study showed that mean values of D-Dimer level in the COVID-19 cases were increased both in survivor and non survivor cases. The mean values of PT, APTT, INR and D-Dimer were higher in non survivor cases (PT 12.31 seconds; APTT 31.78 seconds; INR 1.15; D-Dimer 4.6 mg/L) than survivor case (PT 11.63 seconds; APTT 28.43 seconds; INR 1.12; D-Dimer 2.31 mg/L) while the platelet count was the opposite (288.28 in survivor cases; 281.89 in non survivor cases). The difference was statistically significant (P <0.005) in PT, APTT and D-Dimer variables between survivor and non survivor cases. However, the relationship between hemostasis factors and outcome of patient with COVID-19 was found to be very weak on the platelets, PT, APTT and INR variables (ρ = 0-0.25; P <0.005) and weak on the D-Dimer variable (ρ = 0.26-0.50; P <0.005).
Conclusions: Most COVID-19 cases cause coagulopathy conditions. However, considering the risk of poor outcomes, further studies should investigate the prognostic role of hemostatic parameters in COVID-19 patients.
Toma de decisiones en la Suplementación: técnicas que estimulan la succión efectiva y favorecen el éxito de la Lactancia Materna. Reporte de casos.
Authors: Saavedra Sepulveda Araceli , Molina Sandoval Josefa , Prieto Gómez Ruth 
Published: January 2022

Introducción: Existe consenso respecto de los beneficios de la lactancia materna (LM). Sin embargo, se puede presentar dificultades para amamantar debido a diferentes causas. Los equipos profesionales deben conocer las diferentes herramientas para apoyar en el establecimiento y mantención de la LM. Objetivo: exponer los resultados de casos clínicos con éxito en el uso de la técnica de suplementación por bránula al dedo y proponer un flujograma para la toma de decisiones en la suplementación. Material y método: Se presentan 3 casos clínicos con dificultades para establecer la lactancia, implementando el método de bránula al dedo como técnica de suplementación. Una vez alcanzado el rendimiento motor orofacial necesario para la alimentación, se comienza con la técnica de suplementación de sonda al pecho. Descripción de casos y resultados: La suplementación es llevada a cabo por la madre o acompañante, guiada por un profesional capacitado. Los pilares fundamentales son: exclusión de tetinas, favorecer y entrenar el patrón de succión del lactante y la comunicación fluida con la madre. Conclusión: La técnica de suplementación temporal por bránula ha mostrado buenos resultados en los casos presentados. Esta técnica se centra en la estimulación de la succión del lactante, acompañamiento integral y trabajo en equipo.
PENGERAUH PENGETAHUAN ANGGARAN ANGGOTA DEWAN TERHADAP PENGAWASAN KEUANGAN DAERAH (APBD) DENGAN PARTISIPASI MASYARAKAT DAN AKUNTABILITAS PUBLIK SEBAGAI VARIABEL PEMODERASI (STUDY EMPIRIS PADA DPRD PROVINSI JAMBI)
Authors: Ramadhan Ivan , Wiralestari Wiralestari , Zamzami Zamzami 
Published: January 2022

Penelitian ini bertujuan untuk menguji pengaruh pengetahuan anggaran anggota Dewan terhadap pengawasan keuangan daerah (APBD), yang dimoderasi oleh partisipasi masyarakat dan akuntabilitas publik. Variabel independen dalam penelitian ini adalah pengetahuan anggaran anggota Dewan dan variabel dependenya adalah pengawasan keuangan daerah. Sampel dalam penelitian ini adalah anggota DPRD Provinsi Jambi periode 2019-2024 diperoleh dengan metode sampel jenuh . Jumlah responden dalam penelitian ini adalah sebanyak 55 orang. Pengumpulan data dilakukan dengan menggunakan kuesioner yang diantarkan langsung oleh peneliti. Hasil penelitin ini menunjukkan bahwa pertama, terdapat pengaruh antara pengetahuan anggaran anggota Dewan terhadap pengawasan keuangan daerah yaitu nilai sig 0,000 < 0,05 (a=5%). Kedua dengan nilai sig 0,184 > 0,05 (a=5%) menunjukkan bahwa partisipasi masyarakat tidak memoderasi pengetahuan anggota dewan tentang anggaran berpengaruh terhadap pengawasan keuangan daerah. Ketiga dengan nilai sig 0,412 > 0,05 (a=5%) menunjukkan akuntabilitas publik tidak memoderasi pengetahuan anggota dewan tentang anggaran berpengaruh terhadap pengawasan keuangan daerah.