bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First Ground‐Level Enhancement of Solar Cycle 25 as Seen by the High‐Energy Particle Detector (HEPD‐01) on Board the CSES‐01 Satellite
Authors: Martucci Matteo , Laurenza Monica , Benella Simone , Berrilli Francesco , Del Moro Dario , Giovannelli Luca , Parmentier Alexandra , Piersanti Mirko , Albrecht Gabor , Bartocci Simona , Battiston Roberto , Burger William J. , Campana Donatella , Carfora Luca , Consolini Giuseppe , Conti Livio , Contin Andrea , De Donato Cinzia , De Santis Cristian , Follega Francesco Maria , Iuppa Roberto , Lega Alessandro , Marcelli Nadir , Masciantonio Giuseppe , Mergé Matteo , Mese Marco , Oliva Alberto , Osteria Giuseppe , Palma Francesco , Panico Beatrice , Perfetto Francesco , Picozza Piergiorgio , Pozzato Michele , Ricci Ester , Ricci Marco , Ricciarini Sergio Bruno , Sahnoun Zouleikha , Scotti Valentina , Sotgiu Alessandro , Sparvoli Roberta , Vitale Vincenzo , Zoffoli Simona , Zuccon Paolo 
Published: October 2022

AbstractIn this work we present the High‐Energy Particle Detector (HEPD‐01) observations of proton fluxes from space during the 28 October 2021 solar energetic particle event, which produced a ground‐level enhancement on Earth. The event was associated with the major, long‐duration X1‐class flare and the concomitant coronal mass ejection (CME) that erupted from the Active Region 12887. This is the first direct measurement from space of solar particles emitted during the current solar cycle, recorded by a single instrument in the energy range from ∼50 MeV/n up to ∼250 MeV/n. We have performed a Weibull‐modeled spectral analysis of the energy spectrum in the wide energy range 300 keV–250 MeV, obtained from combination of HEPD‐01 proton measurements with the ones from ACE/ULEIS, SOHO/EPHIN, and SOHO/ERNE. The good agreement between data and model, also corroborated by a comparison with other spectral shapes commonly used in these studies, suggests that particles could have possibly been accelerated out from the ambient corona through the contribution of stochastic acceleration at the CME‐driven shock, even if the presence of seed populations influencing spectral shape could not be excluded. Finally, a Solar Proton Release time of 16:01 UTC ± 13 min and a magnetic path‐length of L = 1.32 ± 0.24 AU have been obtained, in agreement with previous results for this event. We remark that new and precise data on protons in the tens/hundreds MeV energy range—like the one provided by HEPD‐01—could shed more light on particle acceleration as well as provide a reliable parametrization of solar energetic particle spectra for Space Weather purposes.
Parent Training Through the Comfort Ability Program for Pediatric Chronic Pain Management: Self-Reported Expectations and Outcomes
Authors: Burns Maureen , Hale Amy E. , Riley Bobbie L. , Donado Carolina , Bujoreanu Simona , Coakley Rachael 
Published: October 2022

Objective: Targeted parent interventions are known to improve outcomes in pediatric pain, but systematic delivery of this type of training for parents is a challenge. The Comfort Ability Program (CAP) is a well-established, manualized intervention, delivered in a single-day intensive workshop format that includes 6 hr of parent training. The primary goal of this article is to systematically evaluate the impact of the parent training arm of this program on parent expectations and outcomes. Method: A sample of parents who attended CAP ( n = 130) and a control sample ( n = 74) completed self-report questionnaires at baseline, 30, and 90 days after baseline. Separately, a sample of parents attending CAP ( n = 537) completed quality improvement (QI) assessments evaluating pretreatment expectations and posttreatment perceived benefits. Results: Preliminary linear mixed model analysis indicate parents who attended CAP demonstrated significant reductions in pain catastrophizing (PCS; β-estimate = -2.57, SE = 1.1, p < .05) and improvements in pain self-efficacy (PSES, β-estimate = −2.14 , SE = .63 ; p < .01) as compared with controls. Parent over protectiveness (ARCS) and parent-report of child pain severity (PPST) did not differ between groups. Coding of parents’ qualitative assessments suggest that parents who attend CAP are actively seeking skills-based training. Postintervention, parents report immediate benefit from an array of program-specific targets, including how to construct a plan for a child’s return to function, social support, and pain neuroscience education. Conclusion: Parents who attend CAP demonstrate significant changes in research-identified parenting practices over time as compared to controls. Additionally, parent report of posttreatment benefit extends beyond pretreatment expectations (i.e., skills training) to include social support and pain education. Implications for Impact Statement Psychologically-based parent skills training and pain education are an essential part of a child’s recovery from chronic pain, but there are many system and patient-level barriers preventing access to such treatment. The Comfort Ability Program (CAP), a brief, manualized intervention for adolescents with chronic pain and their parents, was created specifically to address these barriers to care. This study, including quantitative and qualitative data, finds that parents who completed CAP make positive and lasting changes in how they think about their child’s chronic pain and report benefits from the specific research-supported targets of treatment including skills training, pain education, and social support.
Developing a resiliency model for survival without major morbidity in preterm infants
Authors: Steurer Martina A. , Ryckman Kelli K. , Baer Rebecca J. , Costello Jean , Oltman Scott P. , McCulloch Charles E. , Jelliffe-Pawlowski Laura L. , Rogers Elizabeth E. 
Published: October 2022

Abstract
Objective
Develop and validate a resiliency score to predict survival and survival without neonatal morbidity in preterm neonates <32 weeks of gestation using machine learning.

Study design
Models using maternal, perinatal, and neonatal variables were developed using LASSO method in a population based Californian administrative dataset. Outcomes were survival and survival without severe neonatal morbidity. Discrimination was assessed in the derivation and an external dataset from a tertiary care center.

Results
Discrimination in the internal validation dataset was excellent with a c-statistic of 0.895 (95% CI 0.882–0.908) for survival and 0.867 (95% CI 0.857–0.877) for survival without severe neonatal morbidity, respectively. Discrimination remained high in the external validation dataset (c-statistic 0.817, CI 0.741–0.893 and 0.804, CI 0.770–0.837, respectively).

Conclusion
Our successfully predicts survival and survival without major morbidity in preterm babies born at <32 weeks. This score can be used to adjust for multiple variables across administrative datasets.
Plasmonic high-entropy carbides
Authors: Calzolari Arrigo , Oses Corey , Toher Cormac , Esters Marco , Campilongo Xiomara , Stepanoff Sergei P. , Wolfe Douglas E. , Curtarolo Stefano 
Published: October 2022

AbstractDiscovering multifunctional materials with tunable plasmonic properties, capable of surviving harsh environments is critical for advanced optical and telecommunication applications. We chose high-entropy transition-metal carbides because of their exceptional thermal, chemical stability, and mechanical properties. By integrating computational thermodynamic disorder modeling and time-dependent density functional theory characterization, we discovered a crossover energy in the infrared and visible range, corresponding to a metal-to-dielectric transition, exploitable for plasmonics. It was also found that the optical response of high-entropy carbides can be largely tuned from the near-IR to visible when changing the transition metal components and their concentration. By monitoring the electronic structures, we suggest rules for optimizing optical properties and designing tailored high-entropy ceramics. Experiments performed on the archetype carbide HfTa4C5 yielded plasmonic properties from room temperature to 1500K. Here we propose plasmonic transition-metal high-entropy carbides as a class of multifunctional materials. Their combination of plasmonic activity, high-hardness, and extraordinary thermal stability will result in yet unexplored applications.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
Authors: Green Simon R. , Davis Susan H. , Damerow Sebastian , Engelhart Curtis A. , Mathieson Michael , Baragaña Beatriz , Robinson David A. , Tamjar Jevgenia , Dawson Alice , Tamaki Fabio K. , Buchanan Kirsteen I. , Post John , Dowers Karen , Shepherd Sharon M. , Jansen Chimed , Zuccotto Fabio , Gilbert Ian H. , Epemolu Ola , Riley Jennifer , Stojanovski Laste , Osuna-Cabello Maria , Pérez-Herrán Esther , Rebollo María José , Guijarro López Laura , Casado Castro Patricia , Camino Isabel , Kim Heather C. , Bean James M. , Nahiyaan Navid , Rhee Kyu Y. , Wang Qinglan , Tan Vee Y. , Boshoff Helena I. M. , Converse Paul J. , Li Si-Yang , Chang Yong S. , Fotouhi Nader , Upton Anna M. , Nuermberger Eric L. , Schnappinger Dirk , Read Kevin D. , Encinas Lourdes , Bates Robert H. , Wyatt Paul G. , Cleghorn Laura A. T. 
Published: October 2022

AbstractTuberculosis is a major global cause of both mortality and financial burden mainly in low and middle-income countries. Given the significant and ongoing rise of drug-resistant strains of Mycobacterium tuberculosis within the clinical setting, there is an urgent need for the development of new, safe and effective treatments. Here the development of a drug-like series based on a fused dihydropyrrolidino-pyrimidine scaffold is described. The series has been developed against M. tuberculosis lysyl-tRNA synthetase (LysRS) and cellular studies support this mechanism of action. DDD02049209, the lead compound, is efficacious in mouse models of acute and chronic tuberculosis and has suitable physicochemical, pharmacokinetic properties and an in vitro safety profile that supports further development. Importantly, preliminary analysis using clinical resistant strains shows no pre-existing clinical resistance towards this scaffold.
Metabolite profiling of Arabidopsis mutants of lower glycolysis
Authors: Zhang Youjun , Fernie Alisdair R. 
Published: October 2022

AbstractWe have previously shown that in Arabidopsis the three enzymes of lower glycolysis namely phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which plays an important role in tethering the mitochondria to the chloroplast. Given that the metabolism of these mutants, the complemented of pgam mutant and overexpression lines of PGAM were unclear, here, we present gas chromatography mass spectrometry-based metabolomics data of them alongside their plant growth phenotypes. Compared with wild type, both sugar and amino acid concentration are significantly altered in phosphoglycerate mutase, enolase and pyruvate kinase. Conversely, overexpression of PGAM could decrease the content of 3PGA, sugar and several amino acids and increase the content of alanine and pyruvate. In addition, the pgam mutant could not be fully complemented by either a nuclear target pgam, a side-directed-mutate of pgam or a the E.coli PGAM in term of plant phenotype or metabolite profiles, suggesting the low glycolysis complete formation is required to support normal metabolism and growth.
Residential trajectories across the life course and their association with cognitive functioning in later life
Authors: Orsholits Dan , Cullati Stéphane , Cheval Boris , Ghisletta Paolo , Oris Michel , Maurer Jürgen , Studer Matthias , Marques Adilson , Marconcin Priscila , Gouveia Élvio R. , Kliegel Matthias , Ihle Andreas 
Published: October 2022

AbstractPrevious work has found that later life urban–rural differences in cognitive health can be largely explained by indicators of cognitive reserve such as education or occupation. However, previous research concentrated on residence in limited, specific, periods. This study offers a detailed investigation on the association between urban (vs. rural) residence from birth, and cognitive functioning in older age. Using data from the Survey of Health Ageing and Retirement in Europe we created residential trajectories from birth to survey enrolment with a combination of sequence and cluster analysis. Using mixed-effects models, we investigated the association between residential trajectories in early, mid, and later life and three cognitive functioning outcomes: immediate recall, delayed recall, and verbal fluency. In a sample of 38,165 participants, we found that, even after accounting for differences related to education and occupation, rural (vs. urban) residence in early life remained associated with poorer cognitive performance later in life. This suggests that growing up in rural regions leads to a long-term disadvantage in cognitive functioning. Thus, public health policies should consider that urban–rural inequalities in early life may have long-lasting associations with inequalities in cognitive health in old and very old age.
Localized mesospheric ozone destruction corresponding to isolated proton aurora coming from Earth’s radiation belt
Authors: Ozaki Mitsunori , Shiokawa Kazuo , Kataoka Ryuho , Mlynczak Martin , Paxton Larry , Connors Martin , Yagitani Satoshi , Hashimoto Shion , Otsuka Yuichi , Nakahira Satoshi , Mann Ian 
Published: October 2022

AbstractRelativistic electron precipitation (REP) from the Earth’s radiation belt plays an important role in mesospheric ozone loss as a connection between space weather and the climate system. However, the rapid (tens of minutes) destruction of mesospheric ozone directly caused by REP has remained poorly understood due to the difficulty of recognizing its location and duration. Here we show a compelling rapid correspondence between localized REP and ozone destruction during a specific auroral phenomenon, the called an isolated proton aurora (IPA). The IPA from the Earth’s radiation belt becomes an important spatial and temporal proxy of REP, distinct from other auroral phenomena, and allowing visualizing micro-ozone holes. We found ozone destruction of as much as 10–60% within 1.5 h of the initiation of IPA. Electromagnetic ion cyclotron waves in the oxygen ion band observed as the driver of REP likely affect through resonance with mainly ultra-relativistic (> 2 mega-electron-volts) energy electrons. The rapid REP impact demonstrates its crucial role and direct effect on regulating the atmospheric chemical balance.
A feasibility study to assess Mediterranean Diet adherence using an AI-powered system
Authors: Papathanail Ioannis , Vasiloglou Maria F. , Stathopoulou Thomai , Ghosh Arindam , Baumann Manuel , Faeh David , Mougiakakou Stavroula 
Published: October 2022

AbstractMediterranean diet (MD) can play a major role in decreasing the risks of non-communicable diseases and preventing overweight and obesity. In order for a person to follow the MD and assess their adherence to it, proper dietary assessment methods are required. We have developed an Artificial Intelligence-powered system that recognizes the food and drink items from a single meal photo and estimates their respective serving size, and integrated it into a smartphone application that automatically calculates MD adherence score and outputs a weekly feedback report. We compared the MD adherence score of four users as calculated by the system versus an expert dietitian, and the mean difference was 3.5% and statistically not significant. Afterwards, we conducted a feasibility study with 24 participants, to evaluate the system’s performance and to gather the users’ and dietitians’ feedback. The image recognition system achieved 61.8% mean Average Precision for the testing set and 57.3% for the feasibility study images (where the ground truth was taken as the participants’ annotations). The feedback from the participants of the feasibility study was also very positive.
Low-temperature argon plasma jet with cascading electrode technique for biological applications
Authors: Seyfi Pourya , Keshavarzi Maryam , Zahedi Saeed , Khademi Ahmad , Ghomi Hamid 
Published: October 2022

AbstractIn this study, the design, performance, and characteristics of a low-temperature argon plasma jet with cascading electrode technique (APJCE) are presented. APJCE is designed based on a tip-ring structure with a cascading ring. The effect of plasma jet driven by repetitive high-voltage microsecond pulses in APJCE structure was measured qualitatively in local surface temperature detection system. Then, by applying the generated plasma jet to biological surface and measuring and characterizing the electrical parameters, we obtained a plasma jet, which is electrically and thermally in the cold plasma regime. Simulation of the electric field distribution in the nozzle also yielded similar results to the experimental results. Finally, by cascading electrodes, we guided the plasma column to the nozzle output so that the plasma temperature within four centimeters of the nozzle output is 37 °C. The resulting plasma jets were studied by atomic emission spectroscopy and the intensity of the spectral lines of the atmospheric argon plasma jet spectra was obtained as a final experimental result at the output.
Closed‐form expressions and statistical analysis of constant false alarm rate detection in multiple false target jamming condition
Authors: Chen Xiaozhou , Jin Ke , Wang Xiaobo , Hu Mengzhong 
Published: October 2022

AbstractMultiple false target jamming is an effective electronic attack measurement that will deteriorate the detection performance of radar constant false alarm rate (CFAR) detector, but its effects lack sufficient exploration. To solve the problem, an upgraded Bernoulli experiment model (BEM) is established and deduced using direct integral method. Given the number of jamming pulses in different cells, the detection performance can be obtained analytically. BEM can provide a meaningful physical view of CFAR from energy perspective, unveiling the mechanism how jamming deteriorate CFAR performance. Real multiple false target jamming is an extension of BEM where pulses are randomly located. This can be solved by integrating the distribution of jamming pulses into BEM which is named as statistical model (SM). Numerical examples validate that BEM and SM are more accurate and thousands of times faster than Monte‐Carlo results. Influential parameters are discussed and some valuable suggestions for radar counter‐countermeasurement are obtained.
Local environmental effects on cosmic ray observations at Syowa Station in the Antarctic: PARMA-based snow cover correction for neutrons and machine learning approach for neutrons and muons
Authors: Kataoka Ryuho , Sato Tatsuhiko , Kato Chihiro , Kadokura Akira , Kozai Masayoshi , Miyake Shoko , Murase Kiyoka , Yoshida Lihito , Tomikawa Yoshihiro , Munakata Kazuoki 
Published: October 2022

Solar modulation of galactic cosmic rays around the solar minimum in 2019–2020 looks different in the secondary neutrons and muons observed at the ground. To compare the solar modulation of primary cosmic rays in detail, we must remove the possible seasonal variations caused by the atmosphere and surrounding environment. As such surrounding environment effects, we evaluate the snow cover effect on neutron count rate and the atmospheric temperature effect on muon count rate, both simultaneously observed at Syowa Station in the Antarctic (69.01° S, 39.59° E). A machine learning technique, Echo State Network (ESN), is applied to estimate both effects hidden in the observed time series of the count rate. We show that the ESN with the input of GDAS data (temperature time series at 925, 850, 700, 600, 500, 400, 300, 250, 200, 150, 100, 70, 50, 30, and 20 hPa) at the local position can be useful for both the temperature correction for muons and snow cover correction for neutrons. The corrected muon count rate starts decreasing in late 2019, preceding the corrected neutron count rate which starts decreasing in early 2020, possibly indicating the rigidity-dependent solar modulation in the heliosphere.
Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia
Authors: Liberato José Luiz , Rosa Marcela Nunes , Miranda Matheus C. Romeiro , Lopes João Luís Callegari , Lopes Norberto Peporine , Gobbo-Neto Leonardo , Fontana Andreia C. K. , dos Santos Wagner Ferreira 
Published: October 2022

Abstract
Lychnophora is a genus of South American flowering plants in the daisy family, popularly known as “Brazilian arnica”. It is used in traditional medicine as an anti-inflammatory and
analgesic agent, whose active components are derived from chlorogenic acid (CGA) and C-flavonoids. Since the drugs currently used are ineffective to treat glaucoma, agents with antioxidant
and anti-inflammatory properties may represent new alternatives in preventing cellular lesions in retinal ischemia. In this study, we report the neuroprotective effects of CGA and
4,5-di-O-[E]-caffeoylquinic (CQA) acid, isolated from Lychnophora plants, in a rodent glaucoma model. Wistar rats were administered intravitreally with 10 µg CGA or CGA, and
then subjected to acute retinal ischemia (ISC) by increasing intraocular pressure (IPO) for 45 minutes followed (or not) by 15 minutes of reperfusion (I/R). Qualitative and quantitative
analyses of neurodegeneration were performed using hematoxylin-eosin or Fluoro-Jade C staining protocols. All retinas submitted to ISC or I/R exhibited matrix disorganization, pyknotic
nuclei, and pronounced vacuolization of the cytoplasm in the ganglion cell layer (GCL) and inner nuclear layer (INL). Pretreatment with CGA or CQA resulted in the protection of the retinal
layers against matrix disorganization and a reduction in the number of vacuolized cells and pyknotic nuclei. Also, pretreatment with CGA or CQA resulted in a significant reduction in
neuronal death in the GCL, the INL, and the outer nuclear layer (ONL) after ischemic insult. Our study demonstrated that CGA and CQA exhibit neuroprotective activities in retinas subjected
to ISC and I/R induced by IPO in Wistar rats.
Unexpected Prolonged Survival in a Case of Cerebellar GBM: An Interesting Case with Literature Review
Authors: Nandan Maruti , Patnaik Ashish , Sahu Rabi Narayan , Dikshit Priyadarshi , Maurya Ved P. , Das Kuntal K. , Kumar Raj 
Published: October 2022

AbstractGlioblastoma multiforme (GBM) of cerebellar hemisphere is a rare entity and constitutes less than 1% of all the GBMs. The rarity of occurrence leads to significant challenge in differentiating morphologically from other subtypes of glioma in the posterior fossa. Previous studies have suggested that cerebellar GBM occurs in the younger age group as compared with the supratentorial counterpart.Here, we report a case of cerebellar GBM in a young adult and discuss the pathogenesis including radiological and pathological aspects involved in the treatment of cerebellar GBM.