bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Metal‐Organic Framework with Nonpolar Pore Surfaces for the One‐Step Acquisition of C2H4from a C2H4and C2H6Mixture
Authors: Di Zhengyi , Liu Caiping , Pang Jiandong , Zou Shuixiang , Ji Zhenyu , Hu Falu , Chen Cheng , Yuan Daqiang , Hong Maochun , Wu Mingyan 
Published: August 2022

AbstractBecause C2H4plays an essential role in the chemical industry, economical and energy‐efficient separation of ethylene (C2H4) from ethane (C2H6) is extremely important. With the exception of energy‐intensive cryogenic distillation, there are few one‐step methods to obtain polymer‐grade (≥99.95 % pure) C2H4from C2H4/C2H6mixtures. Here we report a highly stable metal‐organic‐framework (MOF) FJI‐H11‐Me(des) (FJI‐H=Hong's group in Fujian Institute of Research on the Structure of Matter) which features one‐dimensional hexagonal nonpolar pore surfaces constructed by aromatic rings and alkyl groups. This FJI‐H11‐Me(des) adsorbs C2H6rather than C2H4between 273 and 303 K. Practical breakthrough experiments with C2H4containing 1 % C2H6have shown that FJI‐H11‐Me(des) can realize the acquisition in one‐step of polymer‐grade, 99.95 % pure C2H4under various conditions including different gas flow rates, temperatures and relative humidity.
Curing of an epoxy adhesive with fixed‐frequency microwaves in the presence of a microwave absorber (activated carbon) and with the variable frequency microwave method
Authors: Horikoshi Satoshi , Arai Yuhei , Mura Haruka , Serpone Nick 
Published: August 2022

AbstractThis study examines the curing characteristics of an epoxy resin adhesive mixed with activated carbon (AC) particulates as the microwave absorption heating element (MAHE) using a non‐fluctuating microwave irradiation device consisting of a semiconductor microwave generator and a single‐mode applicator. The advantages of the microwave curing method are the more rapid heating of the epoxy resin adhesive and the associated reduction in curing time. However, problems arose unique to microwave heating as the AC particulates formed aggregates as a result of the microwaves' electric field (E‐field), which also led to a temperature distribution greater than 100°C generated in the epoxy resin adhesive. This problem could not be resolved by commercial microwave chemical equipment. Resolution of the problem was achieved using a variable frequency microwave (VFM) irradiation method using a semiconductor generator; high‐speed electrical diffusion of the E‐field was performed to irradiate with an average electric field without fluctuations. This achieved a uniform curing of the adhesive containing the MAHE particulates using the VFM method, which also proved effective in preventing adhesive ignition accidents. E‐field was performed to irradiate with an average electric field without fluctuations. This achieved a uniform curing of the adhesive containing the MAHE particulates using the VFM method, which also proved effective in preventing adhesive ignition accidents.
Osteohistology of Dromornis stirtoni (Aves: Dromornithidae) and the biological implications of the bone histology of the Australian mihirung birds
Authors: Chinsamy Anusuya , Handley Warren D. , Worthy Trevor H. 
Published: August 2022

AbstractThe late Miocene Dromornis stirtoni is the largest of the giant flightless dromornithid birds. Here, we studied 22 long bones (femora, tibiotarsi, tarsometatarsi) of D. stirtoni to assess its osteohistology to deduce various aspects of its life history. Our results show that D. stirtoni took several years (likely, more than a decade), to reach adult body size, after which its growth rate slowed down, and skeletal maturity occurred. This growth strategy differs from that of its Pleistocene relative, Genyornis newtoni, which experienced faster rates of growth to reach adult body size. We propose that these mihirung birds, separated by millions of years, each responded to the prevailing environmental conditions of the time, by selecting for different growth strategies, with D. stirtoni having an extreme K‐selected life history strategy. The presence of medullary bone permitted the identification of female D. stirtoni specimens, and its presence in some bones lacking an OCL layer showed sexual maturity preceded its formation. We postulate that while G. newtoni had a somewhat greater reproductive potential than D. stirtoni, it remained far less than that observed in the extant emu (Dromaius novaehollandiae). Genyornis newtoni survived into the late Pleistocene alongside extant emus and overlapped the arrival of the first humans in Australia, but the former species shortly thereafter became extinct while emus remain prolific.
Design, synthesis, acetylcholinesterase, butyrylcholinesterase, and amyloid‐β aggregation inhibition studies of substituted 4,4ʹ‐diimine/4,4ʹ‐diazobiphenyl derivatives
Authors: Fidan Görkem S. , Parlar Sulunay , Tarikogullari Ayse H. , Alptuzun Vildan , Alpan Ayşe S. 
Published: August 2022

AbstractA series of 4,4′‐diimine/4,4′‐diazobiphenyl derivatives were designed, synthesized, and evaluated for their ability to inhibit both the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, as well as Aβ1–42 aggregation, in vitro. The AChE and BChE inhibition assays demonstrated that all compounds displayed moderate AChE inhibitory activity in the range of IC50 = 5.77–16.22 μM, while they displayed weak or no BChE inhibition. Among the title compounds, compound 2l, 4,4′‐bis(quinolin‐8‐yldiazenyl)‐1,1′‐biphenyl, having a diazo‐quinoline moiety demonstrated the most potent inhibition against AChE with an IC50 value of 5.77 μM. Furthermore, diazo derivatives 2d, 4,4′‐bis[(4‐methoxyphenyl)diazenyl]‐1,1′‐biphenyl, and 2i, 4,4′‐bis(pyridin‐3‐yldiazenyl)‐1,1′‐biphenyl, provided better potency on Aβ1–42 aggregation, with an inhibition value of 74.08% and 78.39% at 100 μM and 55.35% and 61.36% at 25 μM, respectively. Molecular modeling studies were carried out for the most active compound against AChE, compound 2l. All the results suggested that compounds 2d and 2i have better inhibitory potencies on Aβ1–42 aggregation and moderate AChE enzyme activity, and therefore can be highlighted as promising compounds.
Assessing and choosing the optimum blend of biodiesel, hydrogenated vegetable oil, and petroleum diesel based on sustainability in Indonesia
Authors: Syauqi Ahmad , Halimatussadiah Alin , Purwanto Widodo Wahyu 
Published: August 2022

AbstractThe trend towards increasing biofuel blending mandates in several countries has raised a sustainability trilemma, especially for biofuels derived from palm oil. This study aims to find the most sustainable hydrogen production technology for the production of hydrogenated vegetable oil (HVO) and biofuel blending. It assesses the sustainability of palm‐oil‐derived biofuel blending of biodiesel (FAME), HVO, and petroleum diesel. There are three hydrogen production options for HVO: steam methane reforming (SMR), biomass gasification (BG), and electrolysis from solar energy (PVELC). The use of any production option depends on a combination of fuel quality standards and the prioritized sustainability considerations. The fuel quality aspects consist of constraints on the quality of the blend based on EURO‐2, EURO‐4, and EURO‐5 fuel standards, while sustainability priorities lead to varying policy preferences involving economic, environmental, and social sustainability considerations. There are two approaches to determine the most sustainable blend: using the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method and using the sustainability index. The results show that scenarios that favor the economic dimension tend to produce a higher FAME blend, whereas those that prioritize the environment emphasize higher HVO blending with PVELC as the hydrogen production technology. Finally, any scenario that prefers the social aspects tends to produce higher biofuel blending. Overall, to achieve higher sustainability, higher biofuel blending is needed. The policy analysis section concludes that the biofuel policy direction should focus more on combining HVO and FAME so that each can offset the disadvantages of the other. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Business environmental innovation and CO2 emissions: The moderating role of environmental governance
Authors: Albitar Khaldoon , Borgi Hela , Khan Muzammal , Zahra Anum 
Published: August 2022

AbstractThis paper examines the effects of environmental innovation on CO2 emissions as well as the moderating role of environmental governance in this relationship. Based on a sample of companies listed on the London Stock Exchange for the period from 2016 to 2020, the findings show that environmental innovation reduces CO2 emissions including Scope 1 and Scope 2 CO2 emissions. Likewise, our findings are associative of a moderating effect of environmental governance on the environmental innovation‐CO2 emissions nexus. We argue that environmental innovation along with better environmental governance leads to a reduction in CO2 emissions. Our results hold for subsamples of firms with a strong/low environmental governance and ESG performance. Our findings offer important implications for companies and policymakers towards adopting more environmental technologies along with enhancing environmental governance to reduce CO2 emissions.
Managing sustainability—Does the integration of environmental, social and governance key performance indicators in the internal management systems contribute to companies' environmental, social and governance performance?
Authors: Gebhardt Maria , Thun Toni W. , Seefloth Marcel , Zülch Henning 
Published: August 2022

AbstractAssessing whether a company is sustainable or not is challenging for investors. For this reason, it is particularly important how companies integrate and manage sustainability. This paper primarily aims to investigate the effects of implementing environmental, social and governance (ESG) key performance indicators (KPIs) in the internal management system (IMS) on ESG performance. Further, the effect of a consistent use of ESG KPIs in the IMS and the management compensation scheme (MCS) on ESG performance is examined. Using hand‐collected data of the largest German‐listed companies, this study employs t tests for differences in means and ordinary least square (OLS) regressions to study these associations. The results indicate that the implementation of ESG KPIs in the IMS increases ESG performance. In addition, the performance for environmental and social sub‐dimensions is enhanced. No significant influence of a consistent use of ESG KPIs in the IMS and the MCS on ESG performance is observed. The results highlight that implementing ESG KPIs in the IMS is a practical approach to manage sustainability and to increase ESG performance. Our findings have practical and theoretical implications for researchers, regulators and companies considering the integration of sustainability and further communicating transparently and strengthening investor trust.
Protein G: β‐galactosidase fusion protein for multi‐modal bioanalytical applications
Authors: Motabar Dana , Wang Sally , Tsao Chen‐Yu , Payne Gregory F. , Bentley William E. 
Published: August 2022

Abstractβ‐galactosidase (β‐gal) is one of the most prevalent markers of gene expression. Its activity can be monitored via optical and fluorescence microscopy, electrochemistry, and many other ways after slight modification using protein engineering. Here, we have constructed a chimeric version that incorporates a streptococcal protein G domain at the N‐terminus of β‐gal that binds immunoglobins, namely IgG. This protein G: β‐galactosidase fusion enables β‐gal‐based spectrophotometric and electrochemical measurements of IgG. Moreover, our results show linearity over an industrially relevant range. We demonstrate applicability with rapid spectroelectrochemical detection of IgG in several formats including using an electrochemical sensing interface that is rapidly assembled directly onto electrodes for incorporation into biohybrid devices. The fusion protein enables sensitive, linear, and rapid responses, and in our case, makes IgG measurements quite robust and simple, expanding the molecular diagnostics toolkit for biological measurement.
Chemoenzymatic Labeling to Visualize Intercellular Contacts Using Lipidated SortaseA**
Authors: Yamaguchi Satoshi , Ikeda Ryosuke , Umeda Yuki , Kosaka Takahiro , Yamahira Shinya , Okamoto Akimitsu 
Published: August 2022

AbstractMethods to label intercellular contact have attracted attention because of their potential in cell biological and medical applications for the analysis of intercellular communications. In this study, a simple and versatile method for chemoenzymatic labeling of intercellularly contacting cells is demonstrated using a cell‐surface anchoring reagent of a poly(ethylene glycol)(PEG)‐lipid conjugate. The surface of each cell in the cell pairs of interest were decorated with sortase A (SrtA) and triglycine peptide that were lipidated with PEG‐lipid. In the mixture of the two‐cell populations, the triglycine‐modified cells were enzymatically labeled with a fluorescent labeling reagent when in contact with SrtA‐modified cells on a substrate. The selective labeling of the contacting cells was confirmed by confocal microscopy. The method is a promising tool for selective visualization of intercellularly contacting cells in cell mixtures for cell‐cell communication analysis.
Chrysin sensitizes osteosarcoma cells against TRAIL‐induced apoptosis
Authors: Xie Bin , Yang JunQi , Zhang Jun 
Published: August 2022

AbstractIdentifying novel curative and preventive approaches that can specifically target the osteosarcoma cells (OS) without affecting the normal cells is appreciable. The aim of this study is to investigate the combined effect of chrysin as an apigenin analog with high therapeutic potential and tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) on the treatment of Saos‐2 and MG‐63 cells. Cell viability were determined using MTT method. The rate of apoptosis was assessed by enzyme‐linked immunosorbent assay (ELISA) cell death assay and caspase 8 activity assays. The messenger RNA (mRNA) and protein evaluation of candidate genes include Bcl‐2, XIAP, c‐IAP1, c‐IAP2, and c‐FLIP were accomplished before and after the treatment by quantitative real‐time polymerase chain reaction (PCR) and Western blot analysis, respectively. Our results showed that chrysin synergistically increased the cytotoxic effects of TRAIL as follows: Chrysin plus TRAIL > TRAIL > Chrysin. Chrysin could sensitize both cells against the TRAIL‐induced apoptosis, amplify the caspase 8 activity and this outcome is achieved by decreasing the expression levels of antiapoptotic genes. Our findings suggest that Chrysin can sensitize the OS cell lines against TRAIL through induction of the death receptor pathway. Moreover, the combinational therapy of these agents might be the promising therapeutic regimen for improving the clinical efficacy of TRAIL‐induced apoptosis in patients with OS.
Controllable Reactivity Tuned by the Cooperativity in B/P and B/N Intermolecular Frustrated Lewis Pairs
Authors: Wu Panpan , Mao Hui , Chen Zijiang , Cheng Longjiu , Wang Kun 
Published: August 2022

AbstractFrustrated Lewis pairs (FLPs) are able to heterolytically split hydrogen through the centers of Lewis acid (LA) and Lewis base (LB). In this study, seven typical B/N or B/P intermolecular FLPs composed of LA/LB with different acidity/basicity were selected and designed, where FLPs composed of soft strong LA and hard moderate LB appear to offer best activity and reversibility in hydrogenation. It has been demonstrated that the cooperativity between LA and LB determines the catalytic performance in hydrogen activation. There are two different mechanisms in hydrogenation of FLPs including direct synergetic pathway and single‐electron transfer pathway. For the synergetic mechanism, there are four‐step pathways in hydrogenation dominated by the acidity of the FLPs, while the reversible dehydrogenation is triggered by the isomerization of LB of the FLPs. But for FLPs composed of very weak LA or LB, accelerating single‐electron transfer is an effective method to enhance the reactivity. These results are helpful in designing and synthesizing FLPs with better catalysis efficiency in the field of hydrogen storage or asymmetric hydrogenation.
Intrinsic Regularity of Catalytic Cobalt Chalcogenides in Lithium‐Sulfur Battery: Theoretical Study Delivers New Insights
Authors: Zhang Qi , Zhang Hui‐Ru , Hu Ping‐Ao , Wu Yu‐Cheng 
Published: August 2022

AbstractCobalt chalcogenides CoX2 (X=S, Se, Te) render great performance of lithium‐sulfur batteries based on catalytic capacity to alleviate shuttle effect. Given that S/Se/Te belong to the same main group, the outstanding cycling stability delivered by CoTe2 aroused the curiosity about the uniqueness of CoTe2 and intrinsic laws of cobalt chalcogenide. Herein, comprehensive theoretical study delivers new insights into the intrinsic laws of CoX2: the relative vertical distance of two X atomic layers (rather than atom electronegativity) mainly controls adsorption; CoX2 mainly regulates the charging process (rather than discharging process) thus contributes to great cycling stability. On this basis, the advantages of CoTe2 are three‐fold: moderate polysulfide adsorption, facile ion transport capacity, and surprisingly great promotion of charging process. It is hope the results will facilitate the development of cobalt chalcogenides, especially tellurides as catalytic material in lithium sulfur batteries.
Recent Advances in DNA‐Based Cell Surface Engineering for Biological Applications
Authors: Li Lexun , Liu Shuang , Zhang Chunjuan , Guo Zhenzhen , Shao Shuxuan , Deng Xiaodan , Liu Qiaoling 
Published: August 2022

AbstractDue to its excellent programmability and biocompatibility, DNA molecule has unique advantages in cell surface engineering. Recent progresses provide a reliable and feasible way to engineer cell surfaces with diverse DNA molecules and DNA nanostructures. The abundant form of DNA nanostructures has greatly expanded the toolbox of DNA‐based cell surface engineering and gave rise to a variety of novel and fascinating applications. In this review, we summarize recent advances in DNA‐based cell surface engineering and its biological applications. We first introduce some widely used methods of immobilizing DNA molecules on cell surfaces and their application features. Then we discuss the approaches of employing DNA nanostructures and dynamic DNA nanotechnology as elements for creating functional cell surfaces. Finally, we review the extensive biological applications of DNA‐based cell surface engineering and discuss the challenges and prospects of DNA‐based cell surface engineering.
Structural Insights into the Very Low Activity of the Homocoenzyme B12 Adenosylmethylcobalamin in Coenzyme B12‐Dependent Diol Dehydratase and Ethanolamine Ammonia‐Lyase
Authors: Shibata Naoki , Higuchi Yoshiki , Kräutler Bernhard , Toraya Tetsuo 
Published: August 2022

AbstractThe X‐ray structures of coenzyme B12 (AdoCbl)‐dependent eliminating isomerases complexed with adenosylmethylcobalamin (AdoMeCbl) have been determined. As judged from geometries, the Co−C bond in diol dehydratase (DD) is not activated even in the presence of substrate. In ethanolamine ammonia‐lyase (EAL), the bond is elongated in the absence of substrate; in the presence of substrate, the complex likely exists in both pre‐ and post‐homolysis states. The impacts of incorporating an extra CH2 group are different in the two enzymes: the DD active site is flexible, and AdoMeCbl binding causes large conformational changes that make DD unable to adopt the catalytic state, whereas the EAL active site is rigid, and AdoMeCbl binding does not induce significant conformational changes. Such flexibility and rigidity of the active sites might reflect the tightness of adenine binding. The structures provide good insights into the basis of the very low activity of AdoMeCbl in these enzymes.
Qualitative Vignettes Drawing on Real Cases as Method in Organizational Research
Authors: Marques Nascimento Macêdo Nívea Marcela , Bispo Marcelo de Souza 
Published: August 2022

AbstractThis paper aims to present the importance of qualitative vignettes based on real cases in organizational research and b) to show how to create such vignettes from our experience researching collective decision‐making at a university senate. We defend that qualitative vignette based on real cases are a promising methodological resource in organizational research because they open space for people to reflect on what they do, evoking their actions and the dynamic of social practices of groups they are involved. We concluded that vignettes based on real cases increase the trustworthiness of data generated by the research and are also a good option to be combined with other qualitative methods.
Development of Urease Inhibitors by Fragment‐Based Dynamic Combinatorial Chemistry
Authors: Wu Yao , Zhao Shuang , Liu Changming , Hu Lei 
Published: August 2022

AbstractIn this study, fragment‐based dynamic combinatorial chemistry (DCC) was explored for the development of novel urease inhibitors. Based on a rationally designed fragment, two iteratively evolved dynamic combinatorial libraries (DCLs) were generated and screened in the presence of urease template. The best ligand identified revealed not only strong urease inhibition but also low cytotoxicity. Additionally, a possible inhibitory mechanism was elucidated in the binding kinetics study and docking simulation.
Risk of prostate cancer and death after benign transurethral resection of the prostate—A 20‐year population‐based analysis
Authors: Hilscher Maria , Røder Andreas , Helgstrand J. Thomas , Klemann Nina , Brasso Klaus , Vickers Andrew Julian , Stroomberg Hein Vincent 
Published: August 2022

BackgroundThe oncological risks after benign histology on a transurethral resection of the prostate (TURP) remain largely unknown. Here, the risk of prostate cancer incidence and mortality following a benign histological assessment of TURP is investigated in a population‐based setting.MethodsBetween 1995 and 2016, 64,059 men in Denmark underwent TURP without prior biopsy of the prostate; 42,558 of these men had benign histology. The risks of prostate cancer, prostate cancer with a Gleason score ≥ 3 + 4, and prostate cancer–specific death were assessed with competing risks. Specific risks for pre‐TURP prostate‐specific antigen (PSA) levels at 10 and 15 years were visualized by locally estimated scatterplot smoothing.ResultsThe median age at TURP was 72 years (interquartile range [IQR], 65–78 years), and the median follow‐up was 15 years (IQR, 10–19 years). The 10‐year risks of any prostate cancer and prostate cancer with a Gleason score ≥ 3 + 4 and the 15‐year risk of prostate cancer death showed clear visual relations with increasing PSA. The 15‐year cumulative incidence of prostate cancer–specific death after benign TURP was 1.4% (95% confidence interval [CI], 1.3%–1.6%) for all men and 0.8% (95% CI, 0.6%–1.1%) for men with PSA levels <10 ng/ml. The primary limitation was exclusion due to missing PSA data.ConclusionsMen with low PSA levels and a benign TURP can be reassured about their cancer risk and do not need to be monitored differently than any other men. Patients with high PSA levels can be considered for further follow‐up with prostate magnetic resonance imaging. These findings add to the literature suggesting that normal histology from the prostate entails a low risk of death from the disease.Lay summary

There is little knowledge about the oncological risks after the surgical treatment of benign prostatic hyperplasia.

This study shows a very low risk of adverse oncological outcomes in men with prostate‐specific antigen (PSA) levels below 10 ng/ml at the time of transurethral resection of the prostate.

Patients with higher PSA levels may need more extensive follow‐up.