bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal Replacement Technologies in the Intensive Care of Patients with Acute Necrotizing Pancreatitis
Authors: Никитина Е.В. , Илюкевич Г.В. 
Published: February 2022

В настоящее время высокий уровень летальности при остром панкреатите связан с увеличением доли деструктивных форм заболевания. В современной клинической практике наряду с традиционными методами интенсивной терапии, направленными на ключевые факторы патогенеза, применяются и новые подходы, в частности заместительная почечная терапия (ЗПТ). В представленном обзоре рассмотрены современные представления о месте ЗПТ в интенсивной терапии острого некротизирующего панкреатита (ОНП). Показано, что у пациентов с полиорганной дисфункцией раннее применение методов ЗПТ своевременно купирует эндогенную интоксикацию и гипоксию, тем самым снижая вероятность их прогрессирования и уровень летальности. До сих пор в литературе нет единого мнения о стратегии применения ЗПТ у пациентов с ОНП. Результаты многочисленных исследований весьма противоречивы. Отсутствует единое мнение по поводу показаний к началу проведения ЗПТ, длительности и завершению процедуры. Дискутабельными остаются вопросы о преимуществах одного вида продленной ЗПТ над другим, выбора режима и критериев оценки эффективности, нет также общей стратегии проведения продленной ЗПТ. Анализ имеющихся литературных данных показал необходимость продолжения дальнейших исследований с целью оценки возможностей и эффективности использования почечно-заместительных технологий в интенсивной терапии пациентов с тяжелым течением острого панкреатита.
Currently, a high mortality rate in acute pancreatitis is associated with an increase in the proportion of destructive forms of the disease. In modern clinical practice, along with traditional methods of intensive therapy aimed at key factors of pathogenesis, new approaches are also used, in particular, renal replacement therapy (RRT). The present review examines the current understanding of the place of RRT in the intensive care of acute necrotizing pancreatitis (АNP). It has been shown that in patients with multiple organ dysfunction, the early use of RRT methods timely stops endogenous intoxication and hypoxia, thereby reducing the likelihood of their progression and the level of mortality. Until now, there is no consensus in the literature on the strategy of using RRT in patients with АNP. The results of numerous studies are very contradictory. There is no consensus on the indications for the start of the RRT, the duration and completion of the procedure. Questions about the advantages of one type of extended RRT over another, the choice of the mode and criteria for evaluating the effectiveness remain debatable, there is also no general strategy for conducting an extended RRT. The analysis of the available literature data has shown the need to continue further studies in order to assess the possibilities and effectiveness of using renal replacement technologies in intensive care of patients with severe acute pancreatitis.
Inheritance of IKZF1 Gene Aberrations in a Recurrent Clone of B-Cell Acute Lymphoblastic Leukemia
Authors: Вшивкова О.С. , Корзик А.В. , Мелешко А.Н. 
Published: February 2022

В данном исследовании мы провели оценку аберраций IKZF1 в парных случаях первичный - рецидив пациентов детского возраста с В-линейным острым лимфобластным лейкозом (В-ОЛЛ) с целью установить частоту и определить рациональность диагностики аберраций при рецидивах заболевания. Данное исследование подтверждает существующую гипотезу о вкладе аберраций IKZF1 в развитие первого рецидива заболевания: частота аберраций составила 10,4% у пациентов с первичным В-ОЛЛ и достигала 27,7% при рецидивах заболевания (p=0,0005). Наши результаты убедительно доказывают передачу аберраций IKZF1 от первичного В-ОЛЛ к рецидиву заболевания в подавляющем большинстве случаев. Наличие аберраций IKZF1 является прогностическим маркером развития первого рецидива, однако нами не выявлено значимых различий в показателях бессобытийной выживаемости после первого рецидива. Таким образом, диагностика аберраций при рецидивах В-ОЛЛ с целью прогнозирования развития второго и последующих рецидивов нецелесообразна. У пациентов с делециями IKZF1, выявленными при первичном ОЛЛ, следует ожидать и вовремя предотвращать развитие ранних рецидивов в период с 18 до 30 месяцев с момента первичного диагноза.
In this study, we assessed IKZF1 aberrations in paired primary-relapse cases of pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) in order to establish the frequency and rationality of the diagnosis of aberrations in relapses of the disease. This study confirms the existing hypothesis on the contribution of IKZF1 aberrations to the development of disease relapse: the frequency of aberrations was 10.4% in patients with primary B-ALL and reached 27.7% in relapse (p=0.0005). Our results convincingly prove the transfer of IKZF1 aberrations from primary ALL to relapse in the majority of cases. The presence of IKZF1 aberrations is a prognostic marker for the development of the first relapse; however, we did not find any significant differences in event-free survival after the first relapse. Thus, the diagnosis of aberrations in ALL relapses in order to predict the development of the second and subsequent relapses is not advisable. In patients with IKZF1 deletions identified in primary ALL, early relapses should be expected and prevented in time between 18 and 30 months after the initial diagnosis.
Clinical Significance of Genetic Mutations in Acquired Aplastic Anemia in Children
Authors: Емельянова И.В. , Углова Т.А. , Мигас А.А. , Быданов О.И. , Алейникова О.В. 
Published: February 2022

Полное экзомное секвенирование позволило выявить у 55,2% пациентов детского возраста с тяжелой приобретенной апластической анемией соматические мутации. Общая выживаемость пациентов, имеющих мутации на момент постановки диагноза и получивших иммуносупрессивную терапию, ниже, чем среди пациентов, не имеющих мутаций (75±9% и 81±8% соответственно). Общая выживаемость пациентов, имеющих мутации в генах, предполагающих иммунологическую дисрегуляцию, ниже (60±22%), чем среди пациентов с другими молекулярно-генетическими изменениями (80±9%) и пациентов с отсутствием мутаций (81±8%). Наиболее неблагоприятную группу составляют пациенты с мутациями в генах MSH3 и POLE_POLD, их общая выживаемость составила 0% и 33±27% соответственно. Наличие мутаций не влияет на достижение гематологического ответа на 64-й и 180-й дни иммуносупрессивной терапии.
Complete exome sequencing (NGS) revealed somatic mutations in 55.2% of pediatric patients with severe acquired aplastic anemia. The overall survival rate for patients with mutations at the time of diagnosis and receiving immunosuppressive therapy is lower than for patients without mutations (75±9% and 81±8%, respectively). The overall survival of patients with mutations in genes suggesting immunological dysregulation is lower (60±22%) than patients with other molecular genetic changes (80±9%) and patients without mutations (81±8%). The most unfavorable group consists of patients with mutations in the MSH3 and POLE_POLD genes, their overall survival rate was 0% and 33±27%, respectively. The presence of mutations does not affect the achievement of the hematological response on days 64 and 180 of immunosuppressive therapy.
PERCEPÇÕES DOS(AS) TÉCNICO-ADMINISTRATIVOS(AS) EM EDUCAÇÃO SOBRE JORNADA DE 30 HORAS NA UFMG
Authors: Sabino Ligia Mara 
Published: February 2022

O texto traz o resultado da pesquisa de mestrado profissional sobre as percepções dos/as técnico-administrativos/as em educação sobre o impacto da mudança da jornada de trabalho de 40h para 30h semanais nos processos de trabalho e na vida desses trabalhadores. A metodologia utilizada foi entrevista semiestruturadas, análise de material documental (dispositivos legais, documentos do sindicato, ofícios institucionais) e revisão bibliográfica. Concluímos que, somente a flexibilização da jornada de trabalho não garante qualidade de vida fora e dentro do trabalho, senão vier acompanhada de outros fatores, como, política de contratação de pessoal, políticas públicas de mobilidade urbana e mudança no imaginário social quanto à divisão sexual e racial do trabalho.
97.6% array area reduction, ReRAM computation-in-memory with hyperparameter optimization based on memory bit-error rate and bit precision of log-encoding simulated annealing
Authors: Misawa Naoko , Taoka Kenta , Matsui Chihiro , Takeuchi Ken 
Published: February 2022

Abstract
This paper proposes small array area and memory error tolerant resistive random access memory (ReRAM) computation-in-memory (CiM) with hyperparameter optimization based on bit-error rate (BER) and bit precision of log-encoding simulated annealing (SA). For combinatorial optimization problems, the proposed ReRAM CiM with log-encoding SA reduces the array area by 97.6%, compared with the conventional linear-encoding. To analyze ReRAM device error characteristics, “0” and “1” error injection is applied. The asymmetric ReRAM error improves the acceptable BER by 10 times and the acceptable bit precision to 4 bit. By adjusting the random flips and a cooling parameter, the numbers of flips and iterations decrease by 40% and 33%, respectively. Error injected (EI) iteration is changed to reproduce bit-error due to read disturb. The delay of EI iteration increases the acceptable BER by 25%. Furthermore, in the case of requiring extremely high accuracy, hyperparameter optimization improves the probability of obtaining the optimal answer by 1%.
Improvement of extrapolating frequency response of hydrophone sensitivity using numerical simulation that includes assumptions about materials and construction of hydrophone for measuring instantaneous acoustic pressure of diagnostic ultrasound
Authors: Chiba Yusuke , Umemura Shin-ichiro , Yoshioka Masahiro 
Published: February 2022

Abstract
To evaluate the safety of diagnostic ultrasound, a precise and practical technique for measuring instantaneous acoustic pressure using the frequency response of hydrophone sensitivity has been investigated. We previously confirmed that the extrapolation of the frequency response using constants that are equal to extremes of the frequency range of certificated hydrophone sensitivities is generally effective when this frequency range is narrower than that from 0.5 to 8 times the center frequency of the measured ultrasound. However, this method is not always effective for hydrophones with large frequency response fluctuations. Here, we study whether the effectiveness of the extrapolation could be improved by using numerical simulation that includes assumptions about the materials and construction of the hydrophone and present the prospect that diagnostic ultrasound can be precisely measured using certificated sensitivity even if the upper frequency of certificated sensitivity is only up to twice the center frequency of the diagnostic ultrasound.
Enhancement of self-field critical current density by several-tens-MeV ion irradiation in YBa2Cu3O7 films prepared by fluorine-free metal-organic deposition
Authors: Matsui Hiroaki , Yamaguchi Iwao 
Published: February 2022

Abstract
An up to 63% enhancement in critical current density (J
c) was achieved for 1 μm thick YBa2Cu3O7 (YBCO) films at self-field at 77 K by irradiation with 24–84 MeV Au ions. This enhancement is highly unusual, since in YBCO films, J
c at self-field (J
c
sf) is generally insensitive to ion irradiation, unlike J
c in magnetic fields. Our observed film-thickness dependence of the irradiation effect and our microstructure imaging indicate that this rare observation is attributed to an extremely “clean” (i.e. less-disordered) microstructure in the top 700 nm of the layer of our 1 μm thick films prepared via fluorine-free metal-organic deposition. Our results directly indicate that discontinuous 1D vortex-pinning centers (pins) that have the following features effectively enhance MA cm−2-order J
c
sf at 77 K of YBCO films; namely, 5–10 nm in diameter, ∼20 nm in size along a pin track, have a ∼20 nm gap between the pins in a pin track, and are directed in the c-axis.
Noise reduction technique using deep learning for ultrasound imaging during high-intensity focused ultrasound treatment
Authors: Takagi Ryo , Koseki Yoshihiko 
Published: February 2022

Abstract
One of the problems with ultrasound imaging during high-intensity focused ultrasound (HIFU) treatment is that the therapeutic ultrasound components interfere with the diagnostic ultrasound components, making it impossible to monitor the tissue changes during HIFU exposure. In this study, a convolutional neural network (CNN) framework was applied to the reconstructed ultrasound images with HIFU noise to remove the therapeutic ultrasound components while the diagnostic ultrasound components remain intact. In the experiments, the chicken breast was used as a tissue sample and exposed to HIFU in the water tank. The ultrasound images with and without noise were acquired during an intermission period of HIFU exposure and the noise-reduced images was predicted using the proposed multi-layer regression CNN model through the training process. As a result, ultrasound images with sufficient spatial resolution to detect the thermal lesion were acquired.
Managing the risks of negative analysis of the COVID-19 pandemic on socio-economic processes and prospects for the development of the Russian economy
Authors: Kunin V. A. , Smeshko O. G. 
Published: February 2022

Aim. The presented study aims to identify problems and ways to overcome the negative impact of the COVID-19 pandemic on socio-economic processes and prospects for the development of the Russian economy with allowance for the impact of various global risks.Tasks. The authors identify the major problems and barriers hindering the implementation of measures to combat the COVID-19 pandemic and related to its impact on socio-economic processes; document new risks caused by the wave-like nature of the pandemic; investigate the mechanism of the multiplicative destabilizing impact of global risks; determine key methods and tools of preventive risk management to reduce the negative impact of global risks.Methods. This study uses the methods of risk management, forecasting, systems and comparative analysis of retrospective and current information, scientific generalization, and comparison of statistics.Results. The authors provide estimates of the impact of the COVID-19 pandemic on various sectors of the economy and the social sphere. Circular risk structures are identified, which generate chains of positive feedbacks that negatively affect socio-economic processes. New risks generated by the wave-like nature of the pandemic are documented. Financial instruments aimed at attracting additional funds to combat the pandemic are proposed. The reasons for the negative development of the epidemiological situation in Russia and around the world in the fall of 2021 are determined. The mechanism of multiplicative influence of various global risks on economic processes and the social sphere is determined and investigated. Factors preventing the neutralization of the negative impact of global risks and the major methods and tools of preventive risk management that could reduce the negative impact of global risks are identified.Conclusions. The COVID-19 pandemic has become a catalyst for shifting processes in the economy and the social sphere. The processes initiated by the pandemic are enhanced by the multiplicative effect of other global threats, particularly threats to climate and energy security. The impact of the pandemic on economic sectors varies: by generating high risks for some industries, the pandemic gives chances for the development of others – for example, for the wider dissemination of modern information technologies and means of remote communication. The impact of the pandemic on socio-economic processes is wave-like, which causes new risks and requires the implementation of problem-oriented preventive risk management methods and financing tools proposed in this study.
KINERJA APARATUR PENGAWASAN INTERNAL PEMERINTAH (APIP) INSPEKTORAT KABUPATEN BUNGO DILIHAT DARI DISIPLIN KERJA, LINGKUNGAN DAN MOTIVASI KERJA
Authors: Amran Amran 
Published: February 2022

Aparatur Negara dituntut mampu memiliki kinerjanya (pelayanan prima) dan merealisasikan anggaran yang sudah ditargetkan. Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh disiplin kerja, lingkungan kerja dan motivasi kerja secara secara parsial dan simultan terhadap kinerja Aparatur Pengawasan Internal Pemerintah (APIP) dilingkungan Inspektorat Kabupaten Bungo. Populasi dan sampel penelitian ini adalah seluruh Aparatur Pengawasan Internal Pemerintah (APIP) dilingkungan Inspektorat Kabupaten Bungo yang berjumlah 30 orang (sampling jenuh). Teknik analisis data menggunakan model regresi linear berganda. Hasil penelitian menemukan bahwa disiplin kerja, lingkungan kerja, dan motivasi kerja berpengaruh positif dan signifikan terhadap kinerja aparatur pengawasan internal secara bersama-sama dan juga parsial. Uji determinasi didapatkan 57,8% dan sisanya 42,2% dijelaskan oleh variabel lain yang tidak digunakan dalam penelitian ini. Diharapkan aparatur pengawasan internal tetap mempertahankan dan meningkatkan kedisiplinan dan motivasi dilingkungan kerja inspektorat Kabupaten Bungo. Abstract: The State Apparatus must-have performance (excellent service) and realize the targeted budget. The study aims are to determine and analyze the effect of work discipline, work environment, and motivation partially and simultaneously on the performance of the Government Internal Supervisory Apparatus (APIP) within the Bungo Regency Inspectorate. The population and sample of this study were all Government Internal Supervisory Apparatus (APIP) in the Bungo Regency Inspectorate found 30 people (saturated sampling). The data analysis technique used a multiple linear regression model. The results study found that work discipline, work environment, and work motivation had a positive and significant effect on the performance of the internal control apparatus simultaneously and partially. The determination score is 57.8% and 42.2% explained by other variables not used in this study. It's hoped that the internal control apparatus will maintain and improve discipline and motivation in the work environment of the Bungo Regency inspectorate.
Pengaruh Kualitas Pelayanan terhadap Loyalitas Pelanggan Onelight Photography di Kabupaten Banyuwangi
Authors: Rosa Lina Isnalita Nofta , Widodo Joko , Wahyuni Sri 
Published: February 2022

Quality service can provide a sense of pleasure to customers that can have an impact on customer loyalty. This research was conducted to find out the effect of service quality on customer loyalty of Onelight Photography in Banyuwangi Regency. This research is quantitative research. Locciation research is determined by applying the purposive area method, namely in Onelight Photography, Jl. Ikan Mungsing no. 20 Banyuwangi. In determining the number of respondents using the Simple Random Sampling technique with the Slovin formula, there were 53 respondents. The techniques for collecting data used are kuesione,observation, and interviews. Datacollection uses editing, scoring, and tabulation. Inferential analysis uses data analysis that includes simple regression line analysis, regression variant analysis, F test, regression line effectiveness, and standard error of estimates. The acquisition of research showed that the service quality variable had a significant effect on customer loyalty of Onelight Photography in Banyuwangi Regency, namely Fhitung = 256,806 > Ftabel = 4.03 with significance level F = 0.000 <α = 0.05. For the variant value of the regression line which is 0.913 which belongs to a very strong category. The percentage of the percentage of service quality influence on Onelight Photography customer loyalty in Banyuwangi Regency amounted to 83.4%. While the rest is 16.6% dominated by other factors that are not discussed such as promotion, products and prices. This research can be concluded that there is a significant influence on the quality of service on customer loyalty of Onelight Photography in Banyuwangi Regency by 83.4%.
Порфирия кутанеа тарда – рядка извънчернодробна проява при пациент с хроничен вирусен С хепатит
Authors: Црънчева Радослава , Петрова Диана , Пенчева Венцислава , Велинов Любомир , Григоров Илиан , Кьосева Диана 
Published: February 2022

Порфирия кутанеа тарда е рядко заболяване, резултат от ниска активност на ензима уропорфириноген декарбоксилаза. Тя участва в стъпалообразния процес на синтез на хема в молекулата на хемоглобина. Като резултат се увеличават порфирините и техните предшественици, които се натрупват в кръвта, черния дроб и кожата. Потенциални отключващи фактори са хроничен вирусен С хепатит, алкохол, HIV инфекция, естроген-съдържащи медикаменти и тютюнопушене.
Представяме клиничен случай на 63-годишен пациент с хроничен С хепатит, чернодробна цироза и кожна порфирия. Клиничната проява на порфирията включваше болезнени везикулозни лезии по изложените на слънце кожни зони. Тримесечен терапевтичен курс с директно действащи противовирусни средства доведе до траен вирусологичен отговор с негативиране на вирусната РНК и изчезване на кожните лезии, без да се наблюдават странични ефекти.
Епилептичен синдром с късен дебют, асоцииран с шизенцефалия, при нормално невропсихологично развитие
Authors: Игнатова Валентина , Хараланов Любомир 
Published: February 2022

Шизенцефалията е рядко нарушение на мозъчното кортикално развитие с честота 1.54 / 100 000. Тя се причинява от дефектна миграция на невроните с последващо образуване на цепнатини, простиращи се от pia mater на церебралната стена до подлежащата вентрикулна повърхност. Често е свързана с други мозъчни аномалии като полимикрогирия, пахигирия, вентрикуломегалия, хетеротопия на сивото вещество, агенезия на septum pellucidum, агенезия на корпус калозум и други. Обикновено се съпътства от ментална ретардация, обучителни затруднения и епилептични пристъпи.
Представен е атипичен случай на късен епилептичен дебют при 21-годишен мъж с нормално невропсихично развитие, обусловен от шизенцефалия и агенезия на septum pellucidum.