bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis
Authors: Liu Yanqing , Chen Shiyu , Cai Kun , Zheng Dijie , Zhu Changhao , Li Lin , Wang Feiqing , He Zhiwei , Yu Chao , Sun Chengyi 
Published: March 2022

AbstractAccumulating evidence has demonstrated the essential role of long noncoding RNAs (lncRNAs) in various types of human cancer, including pancreatic cancer (PC). However, the functions and regulatory mechanisms of nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) that are responsible for its role in the malignant progression of PC cells remains to be investigated. In this study, the biological effects of NR2F1-AS1 and NR2F1 in PC were investigated by in vitro and in vivo experiments. The mechanisms of NR2F1-AS1 were monitored by bioinformatic predictive analysis and confirmatory experiments. Our results indicated that NR2F1-AS1 was overexpressed and positively correlated with poor survival in PC. Depletion of NR2F1-AS1 restrained PC cell proliferation, migration, invasion, and suppressed xenograft tumor growth and metastasis in vitro and in vivo. Mechanistic experiments suggested that NR2F1-AS1 positively regulated the neighboring NR2F1 gene, which subsequently activated AKT/mTOR signaling, resulting in the upregulation of hypoxia-inducible factor-1α (HIF-1α). Further investigations elucidated that NR2F1-AS1 expression was transcriptionally regulated by HIF-1α under hypoxia. These findings demonstrated that hypoxia-induced NR2F1-AS1 expression directly increased NR2F1 levels to promote PC cell proliferation, migration, and invasion by activating AKT/mTOR signaling. Together, these findings suggest that NR2F1-AS1 could be a prospective therapeutic target for PC.
Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections
Authors: Feng Jian , Zhang Teng , Sorel Océane , Meng Wen , Zhang Xinquan , Lai Zhao , Yuan Weiming , Chen Yidong , Huang Yufei , Gao Shou-Jiang 
Published: March 2022

AbstractN6-methyladenosine (m6A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA biology. While m6A modifications during numerous viral infections have been described, the role of m6A in innate immune response remains unclear. Here, we examined cellular m6A epitranscriptomes during infections of Pseudomonas aeruginosa and herpes simplex virus type 1 (HSV-1), and lipopolysaccharide (LPS) stimulation to identify m6A-regulated innate immune response genes. We showed that a significant portion of cellular genes including many innate immune response genes underwent m6A modifications in 5'UTR and 3'UTR. We identified common and distinct m6A-modified genes under different stimulating conditions. Significantly, the expression of a subset of innate immune response genes was positively correlated with m6A level. Importantly, we identified genes that had significant enrichments of m6A peaks during P. aeruginosa infection following knockdown of m6A “eraser” ALKBH5, confirming the regulation of these genes by m6A and ALKBH5. Among them, we confirmed the association of m6A modification with gene expression in immune response genes TNFAIP3, IFIT1, IFIT2 and IFIH1. Taken together, our results revealed the vital role of m6A in regulating innate immunity against bacterial and viral infections. These works also provided rich resources for the scientific community.
Bone metabolism in patients with type 1 neurofibromatosis: key role of sun exposure and physical activity
Authors: Ferrara Ursula Pia , Tortora Cristina , Rosano Carmen , Assunto Antonia , Rossi Alessandro , Pagano Stefano , Falco Mariateresa , Simeoli Chiara , Ferrigno Rosario , D’Amico Alessandra , Di Salvio Dario , Cangemi Giuliana , Pivonello Rosario , Strisciuglio Pietro , Melis Daniela 
Published: March 2022

AbstractBone metabolism has been rarely investigated in children affected by Neurofibromatosis type 1 (NF1). Aim of the present study was to assess bone mineral metabolism in children and adults NF1 patients, to determine the relevant factors potentially involved in the development of reduced bone mineral density (BMD), and provide possible therapeutic intervention in NF1 patients. 114 NF1 patients and sex and age matched controls were enrolled into the study. Clinical and biochemical factors reflecting bone metabolism were evaluated. Factors potentially affecting BMD were also investigated including: physical activity, sun exposure, vitamin D intake. Whenever the presence of vitamin D deficiency was recorded, cholecalciferol supplementation was started and z-score data obtained at Dual-Energy X-ray Absorptiometry (DXA) during supplementation were compared with previous ones. NF1 patients showed lower Z-scores at Dual-Energy X-ray Absorptiometry DXA than controls. Physical activity was significantly reduced in NF1 patients than in controls. Sun exposure was significantly lower in NF1 compared to control subjects. At linear regression analysis vitamin D was the most predictive factor of reduced z-score at DXA (p = 0.0001). Cholecalciferol supplementation significantly increased BMD z-score (p < 0.001). We speculated that a combination of different factors, including reduced sun exposure, possibly associated with reduced serum vitamin D levels, and poor physical activity, concur to the impaired bone status in NF1 patients. We also demonstrated that treatment with vitamin D can be effective in improving z-score value in NF1 patients, including children. In conclusion, the findings of the current study are expected to have important implications for the follow-up and prevention of osteopenia/osteoporosis in this common genetic disease.
Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis
Authors: Xiao Wenyuan , Pinilla-Baquero Alejandro , Faulkner John , Song Xuehong , Prabhakar Pradeep , Qiu Hong , Moremen Kelley W. , Ludwig Andreas , Dempsey Peter J. , Azadi Parastoo , Wang Lianchun 
Published: March 2022

AbstractRoundabout 4 (Robo4) is a transmembrane receptor that expresses specifically in endothelial cells. Soluble Robo4 was reported in the human plasma and mouse serum and is inhibitory towards FGF- and VEGF-induced angiogenesis. It remains unknown how soluble Robo4 is generated and if soluble Robo4 regulates additional angiogenic signaling. Here, we report soluble Robo4 is the product of constitutive ectodomain shedding of endothelial cell surface Robo4 by disintegrin metalloproteinases ADAM10 and ADAM17 and acts to inhibit angiogenic Slit3 signaling. Meanwhile, the ligand Slit3 induces cell surface receptor Robo4 endocytosis to shield Robo4 from shedding, showing Slit3 inhibits Robo4 shedding to enhance Robo4 signaling. Our study delineated ADAM10 and ADAM17 are Robo4 sheddases, and ectodomain shedding, including negative regulation by its ligand Slit3, represents a novel control mechanism of Robo4 signaling in angiogenesis.
Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
Authors: Fried Eli , Balla Uri , Catalogna Merav , Kozer Eran , Oren-Amit Adi , Hadanny Amir , Efrati Shai 
Published: March 2022

AbstractData on epidemiology and prognosticators of persistent post-concussion syndrome (PPCS) after mild traumatic brain injury (mTBI) in the pediatric population is scarce. The aim of this study was to evaluate the prevalence of PPCS in children after mTBI and to identify clinical variables in children who are at high risk for developing PPCS. A multicenter, retrospective matched cohort in which PPCS symptoms were evaluated in children 8–15-year-old, 6–60 months after being admitted to the emergency department because of mTBI. The control group included children admitted to the emergency department because of uncomplicated distal radius fractures. The children's guardians were interviewed for the presence of PPCS symptoms using the "Rivermead Post-Concussion Questionnaire". A multivariable logistic regression model was used to identify predictors of PPCS. Two-hundred and five children were included in the mTBI group and 205 in the control. The median time from the injury was 33.5 months in the mTBI group and 33.8 in the control. The prevalence of PPCS in the mTBI group was 25.3% and PPCS like symptoms in the control was 2.4%, p < 0.001. Within the 6–60 months period, the PPCS prevalence was not influenced by the time that elapsed from the injury. In the mTBI group, motor vehicle accidents and adolescence were found to be risk factors for PPCS. PPCS is underdiagnosed in the pediatric population and 25% of children admitted to the ED due to mTBI may suffer from PPCS. Screening guidelines should be implemented to identify and properly treat these children.
2D transistors rapidly printed from the crystalline oxide skin of molten indium
Authors: Hamlin Andrew B. , Ye Youxiong , Huddy Julia E. , Rahman Md Saifur , Scheideler William J. 
Published: March 2022

AbstractUltrathin single-nm channels of transparent metal oxides offer unparalleled opportunities for boosting the performance of low power, multifunctional thin-film electronics. Here we report a scalable and low-temperature liquid metal printing (LMP) process for unlocking the ultrahigh mobility of 2-dimensional (2D) InOx. These continuous nanosheets are rapidly (60 cm s−1) printed over large areas (30 cm2) directly from the native oxide skin spontaneously formed on molten indium. These nanocrystalline LMP InOx films exhibit unique 2D grain morphologies leading to exceptional conductivity as deposited. Quantum confinement and low-temperature oxidative postannealing control the band structure and electronic density of states of the 2D InOx channels, yielding thin-film transistors with ultrahigh mobility (μ0 = 67 cm2 V−1s−1), excellent current saturation, and low hysteresis at temperatures down to 165 °C. This work establishes LMP 2D InOx as an ideal low-temperature transistor technology for high-performance, large area electronics such as flexible displays, active interposers, and thin-film sensors.
Assignment-free chirality detection in unknown samples via microwave three-wave mixing
Authors: Koumarianou Greta , Wang Irene , Satterthwaite Lincoln , Patterson David 
Published: March 2022

AbstractStraightforward identification of chiral molecules in multi-component mixtures of unknown composition is extremely challenging. Current spectrometric and chromatographic methods cannot unambiguously identify components while the state of the art spectroscopic methods are limited by the difficult and time-consuming task of spectral assignment. Here, we introduce a highly sensitive generalized version of microwave three-wave mixing that uses broad-spectrum fields to detect chiral molecules in enantiomeric excess without any prior chemical knowledge of the sample. This method does not require spectral assignment as a necessary step to extract information out of a spectrum. We demonstrate our method by recording three-wave mixing spectra of multi-component samples that provide direct evidence of enantiomeric excess. Our method opens up new capabilities in ultrasensitive phase-coherent spectroscopic detection that can be applied for chiral detection in real-life mixtures, raw products of chemical reactions and difficult to assign novel exotic species.
Probing active sites for carbon oxides hydrogenation on Cu/TiO2 using infrared spectroscopy
Authors: Shaaban Ehab , Li Gonghu 
Published: March 2022

AbstractThe valorization of carbon oxides on metal/metal oxide catalysts has been extensively investigated because of its ecological and economical relevance. However, the ambiguity surrounding the active sites in such catalysts hampers their rational development. Here, in situ infrared spectroscopy in combination with isotope labeling revealed that CO molecules adsorbed on Ti3+and Cu+interfacial sites in Cu/TiO2gave two disparate carbonyl peaks. Monitoring each of these peaks under various conditions enabled tracking the adsorption of CO, CO2, H2,and H2O molecules on the surface. At room temperature, CO was initially adsorbed on the oxygen vacancies to produce a high frequency CO peak, Ti3+−CO. Competitive adsorption of water molecules on the oxygen vacancies eventually promoted CO migration to copper sites to produce a low-frequency CO peak. In comparison, the presence of gaseous CO2inhibits such migration by competitive adsorption on the copper sites. At temperatures necessary to drive CO2and CO hydrogenation reactions, oxygen vacancies can still bind CO molecules, and H2spilled-over from copper also competed for adsorption on such sites. Our spectroscopic observations demonstrate the existence of bifunctional active sites in which the metal sites catalyze CO2dissociation whereas oxygen vacancies bind and activate CO molecules.
Optical excitations of Skyrmions, knotted solitons, and defects in atoms
Authors: Parmee Christopher D. , Dennis Mark R. , Ruostekoski Janne 
Published: March 2022

AbstractAnalogies between non-trivial topologies of matter and light have inspired numerous studies, including defect formation in structured light and topological photonic band structures. Three-dimensional topological objects of localised particle-like nature attract broad interest across discipline boundaries from elementary particle physics and cosmology to condensed matter physics. Here we propose how simple structured light beams can be transformed into optical excitations of atoms with considerably more complex topologies representing three-dimensional particle-like Skyrmions. This construction can also be described in terms of linked Hopf maps, analogous to knotted solitons of the Skyrme-Faddeev model. We identify the transverse polarisation density current as the effective magnetic gauge potential for the Chern-Simons helicity term. While we prepare simpler two-dimensional baby-Skyrmions and singular defects using the traditional Stokes vectors on the Poincaré sphere for light, particle-like topologies can only be achieved in the full optical hypersphere description that no longer discards the variation of the total electromagnetic phase of vibration.
Critical active dynamics is captured by a colored-noise driven field theory
Authors: Maggi Claudio , Gnan Nicoletta , Paoluzzi Matteo , Zaccarelli Emanuela , Crisanti Andrea 
Published: March 2022

AbstractActive matter may sometimes behave almost indistinguishably from equilibrium matter. This is particularly evident for some particle-based models and active field-theories close to a critical point which falls in the Ising universality class. Here we show however that, even when critical, active particles strongly violate the equilibrium fluctuation-dissipation in the high-wave-vector and high-frequency regime. Conversely, at larger spatiotemporal scales the theorem is progressively restored and the critical dynamics is in effective equilibrium. We develop a field-theoretical description of this scenario employing a space-time correlated noise field finding that the theory qualitatively captures the numerical results already at the Gaussian level. Moreover a dynamic renormalization group analysis shows that the correlated noise does not change the equilibrium critical exponents. Our results demonstrate that a correlated noise field is a fundamental ingredient to describe critical active matter at the coarse-grained level.
Quasi-static strain governing ultrafast spin dynamics
Authors: Shin Yooleemi , Vomir Mircea , Kim Dong-Hyun , Van Phuoc Cao , Jeong Jong-Ryul , Kim Ji-Wan 
Published: March 2022

AbstractThe quasi-static strain (QSS) is the product induced by the lattice thermal expansion after ultrafast photo-excitation. Although the ultrafast spin dynamics driven by the QSS and thermal effects are barely distinguishable in time, they should be treated separately because of their different fundamental actions. By employing ultrafast Sagnac interferometry and the magneto-optical Kerr effect, we demonstrate quantitatively the existence of QSS and the decoupling of two effects counteracting each other in typical polycrystalline Co and Ni films. The Landau-Lifshitz-Gilbert and Kittel equations considering a magnetoelastic energy term showed that QSS, rather than the thermal energy, in ferromagnets plays a governing role in ultrafast spin dynamics. This demonstration provides a way to analyze ultrafast photo-induced phenomena.
Quantum imaginary time evolution steered by reinforcement learning
Authors: Cao Chenfeng , An Zheng , Hou Shi-Yao , Zhou D. L. , Zeng Bei 
Published: March 2022

AbstractThe quantum imaginary time evolution is a powerful algorithm for preparing the ground and thermal states on near-term quantum devices. However, algorithmic errors induced by Trotterization and local approximation severely hinder its performance. Here we propose a deep reinforcement learning-based method to steer the evolution and mitigate these errors. In our scheme, the well-trained agent can find the subtle evolution path where most algorithmic errors cancel out, enhancing the fidelity significantly. We verified the method’s validity with the transverse-field Ising model and the Sherrington-Kirkpatrick model. Numerical calculations and experiments on a nuclear magnetic resonance quantum computer illustrate the efficacy. The philosophy of our method, eliminating errors with errors, sheds light on error reduction on near-term quantum devices.
A highly efficient Ti-catalyst for the deoxygenative reduction of esters under ambient conditions: experimental and mechanistic insights from DFT studies
Authors: Bhattacharjee Jayeeta , Rawal Parveen , Das Suman , Harinath Adimulam , Gupta Puneet , Panda Tarun K. 
Published: March 2022

A combined experimental & DFT study of the catalytic deoxygenative reduction of organic esters with HBpin using a TiIV alkyl complex as a competent catalyst to afford corresponding boryl ether at room temperature under neat conditions is reported.
Quantification of molecular aromaticity as a predictive factor of astrophysical significance
Authors: Alvarez-Thon Luis , Lee Timothy J. , Fortenberry Ryan C. , Inostroza-Pino Natalia 
Published: March 2022

Context. This study reports the index of aromaticity calculated by numerical integration of the magnetically-induced current density for cyclic hydrocarbon molecules both known to exist in astrophysical media as well as those proposed to exist.
Aims. This study promotes the ring current strength (RCS) value for quantifying aromaticity as a means of predicting astrophysical detectability.
Methods. Density functional theory (DFT) calculations at the B3LYP/aug-cc-pVTZ level provide optimized structures and the wave-functions needed to provide the RCS values for the molecules analyzed.
Results. The known interstellar molecules examined c-C3H2, c-(O)C3H2, c-C3HC2H, o-benzyne, benzonitrile, 1-cyano and 2-cyanonaphthalene all have RCS values of 9.9 nA T−1 (nanoampere per Tesla) or above. The known antiaromatic species have RCS values of less than 0.0 nA T−1 as expected. Several proposed interstellar molecules likely will not persist if they form due to low RCS values including c-(C)C3H2. Other species such as p-benzyne and c-HCNN+ have high RCS values of 19.9 nAT−1 and 14.4nAT−1, respectively.
Conclusions. Cyclic hydrocarbons previously observed in astrophysical media have high RCS values. Those with low or negative RCS values have yet to be observed implying that such a metric can indicate astrophysical significance.
Optimal timing of rectal diclofenac in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis
Authors: Sperna Weiland Christina J. , Smeets Xavier J.N.M. , Verdonk Robert C. , Poen Alexander C. , Bhalla Abha , Venneman Niels G. , Kievit Wietske , Timmerhuis Hester C. , Umans Devica S. , van Hooft Jeanin E. , Besselink Marc G. , van Santvoort Hjalmar C. , Fockens Paul , Bruno Marco J. , Drenth Joost P.H. , van Geenen Erwin J.M. ,   on behalf of the Dutch Pancreatitis Study Group
Published: March 2022

Abstract
Background and study aims Rectal nonsteroidal anti-inflammatory drug (NSAID) prophylaxis reduces incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Direct comparisons to the optimal timing of administration, before or after ERCP, are lacking. Therefore, we aimed to assess whether timing of rectal NSAID prophylaxis affects the incidence of post-ERCP pancreatitis.
Patients and methods We conducted an analysis of prospectively collected data from a randomized clinical trial. We included patients with a moderate to high risk of developing post-ERCP pancreatitis, all of whom received rectal diclofenac monotherapy 100-mg prophylaxis. Administration was within 30 minutes before or after the ERCP at the discretion of the endoscopist. The primary endpoint was post-ERCP pancreatitis. Secondary endpoints included severity of pancreatitis, length of hospitalization, and Intensive Care Unit (ICU) admittance.
Results We included 346 patients who received the rectal NSAID before ERCP and 63 patients who received it after ERCP. No differences in baseline characteristics were observed. Post-ERCP pancreatitis incidence was lower in the group that received pre-procedure rectal NSAIDs (8 %), compared to post-procedure (18 %) (relative risk: 2.32; 95% confidence interval: 1.21 to 4.46, P = 0.02). Hospital stays were significantly longer with post-procedure prophylaxis (1 day; interquartile range [IQR] 1–2 days vs. 1 day; IQR 1–4 days; P = 0.02). Patients from the post-procedure group were more likely to be admitted to the ICU (1 patient [0.3 %] vs. 4 patients [6 %]; P = 0.002).
Conclusions Pre-procedure administration of rectal diclofenac is associated with a significant reduction in post-ERCP pancreatitis incidence compared to post-procedure use.
Diagnostische Performanz und Validität des deutschsprachigen BDI-II – Eine Sekundäranalyse mit Daten aus klinischen und nichtklinischen Stichproben
Authors: Kuehner Christine , Keller Ferdinand , Schricker Isabelle F. , Beddig Theresa , Huffziger Silke , Timm Christina , Rachota-Ubl Bettina , Hautzinger Martin , Diener Carsten 
Published: March 2022

Zusammenfassung
Ziel der Studie Untersuchung der diagnostischen Klassifikationsgüte und Validität des deutschsprachigen Beck-Depressions-Inventars (BDI-II) in einem kombinierten Datensatz aus Erwachsenenstichproben.
Methode Das BDI-II und das SKID-I als externes Kriterium wurden an 638 Personen erhoben (385 mit akuter oder remittierter Depression, 253 Kontrollen). Die Screeningperformanz des BDI-II wurde für die im Manual vorgeschlagenen Cut-offs und für optimale Cut-offs anhand von ROC-Analysen berechnet.
Ergebnisse Die interne Konsistenz des BDI-II war hoch (> 0,90) und es zeigten sich plausible Zusammenhänge mit konstruktnahen Skalen. Es resultierten optimale Cut-offs mit guter Sensitivität und Spezifität von 16+ für Depressive Episoden (Youden’s J = 0,838) und von 14+ für Depressive Störungen (J = 0,814).
Diskussion Das deutschsprachige BDI-II stellt ein reliables und valides Screeninginstrument für Depressive Episoden und Depressive Störungen in der Erwachsenenbevölkerung dar. Je nach Priorisierung können unterschiedliche Cut-offs herangezogen werden.