bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical presentations, diagnostics, treatments and treatment costs of children and adults with febrile illness in a tertiary referral hospital in south-eastern Guinea: A retrospective longitudinal cohort study
Authors: Raab Manuel , Pfadenhauer Lisa M. , Doumbouya Dansira , Froeschl Guenter 
Published: January 2022

BackgroundFebrile illness is frequent among patients in the tropics. It is caused by a wide variety of common diseases such as malaria or gastrointestinal infections but also by less common but highly contagious pathogens with epidemic potential. This study describes the clinical features of adult and paediatric patients with febrile illness in in the largest tertiary referral hospital in south-eastern Guinea, a region at high risk for viral haemorrhagic fever outbreaks. The study further compares their diagnostic characteristics, treatments and outcomes with non-febrile patients in order to contribute to the local epidemiology of febrile illness.MethodsWe used retrospective data collection to record demographic and clinical data of all incoming patients during a study period of three months. For the follow-up study of inpatients, we retrospectively reviewed patient charts for diagnostic characteristics, diagnoses and outcomes.ResultsOf the 4317 incoming patients during the study period, 9.5% had a febrile illness. The most used diagnostic measures to identify causative agents in febrile patients were point-of-care tests and most treatments relied on antibiotics. Most common discharge diagnoses for febrile inpatients were malaria (9.6% adults, 56.7% children), salmonella gastroenteritis/typhoid (10.6% adults, 7.8% children) and respiratory infection/pneumonia (5.3% adults, 18.7% children). Inpatient mortality for children was significantly higher in febrile than non-febrile children (18.5% vs. 5.1%, p<0.001) and considerably higher in febrile than non-febrile adults (29.8% vs. 25.0%, p = 0.404).ConclusionsMalaria, respiratory infection and gastroenteritis are considered the main causes for febrile illness. The wide reliance on rapid diagnostic tests to diagnose febrile patients not only risks to over- or under-diagnose certain diseases but also leaves the possibility of highly infectious diseases in febrile patients unexplored. Furthermore, the heavy reliance on antibiotics risks to cause antimicrobial resistance. High mortality rates in febrile patients, especially children, should be of concern to public health authorities.
Mediterráneamente. Estudio de eficacia cuantitativa en las películas publicitarias de Estrella Damm
Authors: Rodríguez-Rabadán María , Galán-Fajardo Helena , Del-Pino-Romero Cristina 
Published: January 2022

El objeto de estudio de esta investigación está comprendido por dos de las películas publicitarias de branded content en formato cortometraje, de la marca de cervezas Estrella Damm: Vale (Amenábar, 2015) y Las pequeñas cosas (Rodríguez, 2016), programadas en período estival. Ambas comparten el mismo claim: Mediterráneamente, basado en una estrategia de identificación marca-territorio bajo la fórmula del entretenimiento. Además de tratarse de creación de contenido por parte de una marca o branded content, nos encontramos ante dos casos de branded entertainment. La principal aportación de este artículo es la elaboración de una novedosa propuesta metodológica con el fin analizar el efecto que produce en el espectador una mayor o menor presencia de brand placement en el contexto del branded content. Mediante el Test de Fisher se hace un estudio de eficacia cuantitativa que se aplica a una muestra constituida por 66 personas, alumnado universitario. A partir de las hipótesis se deduce que un mayor o menor número de brand placement no interfiere directamente en la comprensión de los valores de la historia, tampoco influye en una actitud negativa hacia la presencia de la marca. El estudio también demuestra una relación directa entre el nivel de entretenimiento de los cortometrajes y la intención de compra del producto.
Recurrent, Multisubtype Posttransplant Lymphoproliferative Disorder Masquerading as Inflammatory Bowel Disease
Authors: Mussarat Saad , Houston Kevin V. , Parekh Parth J. 
Published: January 2022

ABSTRACT
Posttransplant lymphoproliferative disorder (PTLD) is a severe posttransplant complication that occurs because of immunosuppression within the first year; however, recurrent PTLD or development of multiple histologic subtypes are rare. Our case demonstrates a renal transplant recipient with rare, recurrent PTLD with multiple histologic subtypes (monomorphic and polymorphic PTLD) despite a previous response to rituximab and resolution of inflammatory changes on endoscopy. It is essential that clinicians maintain a high suspicion for PTLD when caring for patients with previous transplantation and that they have a lower threshold for biopsy with endoscopic findings of nonspecific inflammatory changes.
Physicochemical characterization of C-phycocyanin from Plectonema sp. and elucidation of its bioactive potential through in silico approach
Authors: Husain Arbab , Farooqui Alvina , Khanam Afreen , Sharma Shubham , Mahfooz Sadaf , Shamim Adeeba , Akhter Firoz , Alatar Abdulrahman A. , Faisal Mohammad , Ahmad Saheem 
Published: January 2022

C-phycocyanin (C-PC), the integral blue-green algae (BGA) constituent has been substantially delineated for its biological attributes. Numerous reports have illustrated differential extraction and purification techniques for C-PC, however, there exists paucity in a broadly accepted process of its isolation. In the present study, we reported a highly selective C-PC purification and characterization method from nontoxic, filamentous and non-heterocystous cyanobacterium Plectonema sp. C-PC was extracted by freeze-thawing, desalted and purified using ion-exchange chromatography. The purity of C-PC along with its concentration was found to be 4.12 and 245 µg/ml respectively. Comparative characterization of standard and purified C-PC was performed using diverse spectroscopic techniques namely Ultra Violet-visible, fluorescence spectroscopy and Fourier transform infrared (FT-IR). Sharp peaks at 620 nm and 350 nm with UV-visible and FT-IR spectroscopy respectively, confirmed amide I bands at around 1638 cm-1 (C=O stretching) whereas circular dichroism (CD) spectra exhibited α-helix content of secondary structure of standard 80.59% and 84.59% of column purified C-PC. SDS-PAGE exhibited two bands of α and β subunits 17 and 19 kDa respectively. HPLC evaluation of purified C-PC also indicated a close resemblance of retention peak time (1.465 min, 1.234 min, 1.097 min and 0.905 min) with standard C-PC having retention peak timing of 1.448 min, 1.233 min and 0.925 min. As a cautious approach, the purified C-PC was further lyophilized to extend its shelf life as compared to its liquid isoform. To evaluate the bioactive potential of the purified C-PC in silico approach was attempted. The molecular docking technique was carried out of C-PC as a ligand-protein with free radicals and α-amylase, α-glucosidase, glycogen synthase kinase-3 and glycogen phosphorylase enzymes as receptors to predict the free radical scavenging (antioxidant) and to target antidiabetic property of C-PC. In both receptors free radicals and enzymes, ligand C-PC plays an important role in establishing interactions within the cavity of active sites. These results established the antioxidant potential of C-PC and also give a clue towards its antidiabetic potential warranting further research.
Study of flavonoids and phenolic acids in green tea leaves
Authors: Maslov O. Yu. , Kolisnyk S. V. , Komisarenko M. A. , Akhmedov E. Yu. , Poluian S. M. , Shovkova Z. V. 
Published: January 2022

The aim of work is study qualitative composition and quantitative content of flavonoids and phenolic acids in green tea leaves.
Material and methods. The object of the study was green tea leaves, which were collected in Anhui Province, China. The analysis of 60 % ethanolic extract from green tea leaves was performed by high-performance liquid chromatography using a Prominence LC-20 Shimadzu chromatographic system (Japan) with an SPD-20AV spectrophotometric detector, an Agilent Technologies Microsorb-MV-150 column (reversed-phase, C18 modified silica gel, length – 250 mm, diameter – 4.6 mm, particles size – 5 μm). Identification of substances in the extract was carried out by comparing the retention time and the spectral characteristics of the test substances with the same characteristics of the reference standards.
Results. 13 compounds were identified and determined by high-performance liquid chromatography. Among flavonoid aglycones quantitatively dominated by quercetin (0.35 %), in the case of flavonoid glycosides, it was luteolin-6-C-glycoside (1.30 %) and among phenolic acids, it was gallic acid (5.21 %).
Conclusions. The qualitative composition, quantitative content of flavonoids and phenolic acids in the green tea leaves were determined by high-performance liquid chromatography. According to HPLC, the content of flavonoids in green tea leaves was higher than the content of phenolic acids.
Individual versus pair work on L2 speech acts: production and cognitive processes
Authors: Lin Ming-Fang , Chen Yuan-shan , Wu Hui-Ju 
Published: January 2022

Abstract
This study aims to examine the extent to which peer collaboration affects EFL learners’ speech act production and cognitive processes. Eleven EFL students in the individual group and 22 students (11 pairs) in the collaborative groups were asked to report their cognitive processes when working on a written discourse completion task (WDCT). The WDCT performances were rated on a five-point Likert-type scale, and the verbalizations were analyzed in terms of pragmatic-related episodes (PREs). Results showed that the individual group scored higher on content, whereas the collaborative group outperformed their counterparts on forms. Regarding the cognitive processes, the individual group tended to plan the general direction of their writing before writing the WDCT and paid more attention to sociopragmatic content while writing. In contrast, the collaborative group planned specific details before the task and attended to pragmalinguistic forms more often while writing.
Monocyte distribution width (MDW): a useful biomarker to improve sepsis management in Emergency Department
Authors: Poz Donatella , Crobu Danila , Sukhacheva Elena , Rocchi Marco Bruno Luigi , Anelli Maria Chiara , Curcio Francesco 
Published: January 2022

Abstract

Objectives
Sepsis is a time-dependent and life-threating condition. Despite several biomarkers are available, none of them is completely reliable for the diagnosis. This study aimed to evaluate the diagnostic utility of monocyte distribution width (MDW) to early detect sepsis in adult patients admitted in the Emergency Department (ED) with a five part differential analysis as part of the standard clinical practice.

Methods
A prospective cohort study was conducted on 985 patients aged from 18 to 96 and included in the study between November 2019 and December 2019. Enrolled subjects were classified into four groups based on sepsis-2 diagnostic criteria: control, Systemic Inflammatory Response Syndrome (SIRS), infection and sepsis. The hematology analyzer DxH 900 (Beckman Coulter Inc.) provides the new reportable parameter MDW, included in the leukocyte 5 part differential analysis, cleared by Food and Drug administration (FDA) and European Community In-Vitro-Diagnostic Medical Device (CE IVD) marked as early sepsis indicator (ESId).

Results
MDW was able to differentiate the sepsis group from all other groups with Area Under the Curve (AUC) of 0.849, sensitivity of 87.3% and specificity of 71.7% at cut-off of 20.1. MDW in combination with white blood cell (WBC) improves the performance for sepsis detection with a sensitivity increased up to 96.8% when at least one of the two biomarkers are abnormal, and a specificity increased up to 94.6% when both biomarkers are abnormal.

Conclusions
MDW can predict sepsis increasing the clinical value of Leukocyte 5 Part Differential analysis and supporting the clinical decision making in sepsis management at the admission to the ED.
S100B in cardiac surgery brain monitoring: friend or foe?
Authors: Lapergola Giuseppe , Graziosi Alessandro , D’Adamo Ebe , Brindisino Patrizia , Ferrari Mariangela , Romanelli Anna , Strozzi Mariachiara , Libener Roberta , Gavilanes Danilo A. W. , Maconi Antonio , Satriano Angela , Varrica Alessandro , Gazzolo Diego 
Published: January 2022

Abstract
Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B pros and cons in the peri-operative monitoring of adult and pediatric patients.
Failure analysis of motorcycle shock breakers
Authors: Mahendra Afrizal Yose , Prabowo Aditya Rio , Triyono Triyono 
Published: January 2022

AbstractThe shock breaker is one of the most important parts of a motorcycle, which functions as a vibration damper. This study aims to analyze the causes of motorcycle shock breaker failure. The research method used is comprised of visual observation, chemical composition testing, Vickers hardness testing, scanning electron microscopy-energy dispersive X-ray spectroscopy analysis, and tensile testing of a damaged shock breaker. From visual observation, it is found that the damage can be classified as a fatigue fracture, forming a damage pattern at 45°. The chemical composition testing results of the shock breaker fractures show that the material includes low-carbon alloy steel (of ST42 series) with a carbon content of 0.162%. The average hardness value of the damaged part of the shock breaker was increased to 204.87 HV, compared with 171.02 HV in areas far from the damage. The difference in hardness in the shock breaker was caused by the high stress acting on the shock breaker and the consequent strain hardening. The results of this study indicate that the failure mechanism of the motorcycle shock breaker was a functional failure due to errors in the shock breaker manufacturing process and fatigue.
Homogeneous Branching Processes with Non-Homogeneous Immigration
Authors: Rahimov Ibrahim 
Published: January 2022

Abstract
The stationary immigration has a limited effect over the asymptotic behavior of the underlying branching process. It affects mostly the limiting distribution and the life-period of the process. In contrast, if the immigration rate changes over time, then the asymptotic behavior of the process is significantly different and a variety of new phenomena are observed. In this review we discuss branching processes with time non-homogeneous immigration. Our goal is to help researchers interested in the topic to familiarize themselves with the current state of research.
Corporate entrepreneurship programmes as mechanisms to accelerate product innovations
Authors: Ghura Amarpreet Singh , Erkut Burak 
Published: January 2022

Abstract
This paper explores how firms engage in corporate entrepreneurship through programmes, and what kind of outcomes they achieve in terms of innovations. Insights are drawn from four cases of organisations that engaged in corporate entrepreneurial activities. The paper identifies two dimensions of corporate entrepreneurship programmes as idea themes, indicating whether programmes are designed with specific themes in mind, and idea ownership, indicating whether there is a dedicated team to focus on new ideas, or not. These dimensions are under the direct control of management. Based on these two dimensions, four models of corporate entrepreneurial activities are presented linking each of these models to one of the four cases of product innovations (product line extensions, product improvements, new products, start-up businesses). By drawing on the insights of the effectuation and causation logics, the paper provides a fresh perspective of corporate entrepreneurship programmes in an emerging, non-Western cultural setup and the product innovation context. This is primarily done by introducing a 2 × 2 matrix regarding corporate entrepreneurship idea themes and idea ownership in an emerging context.
Efficient degradation of methyl orange and methylene blue in aqueous solution using a novel Fenton-like catalyst of CuCo-ZIFs
Authors: Luong Thanh H. V. , Nguyen Thao H. T. , Nguyen Binh V. , Nguyen Nghia K. , Nguyen Thanh Q. C. , Dang Giao H. 
Published: January 2022

Abstract
In this study, the synthesized CuCo-zeolitic imidazolate framework (ZIF) catalyst was used to degrade methyl orange (MO) and methylene blue (MB) in water via a novel Fenton-like catalytic reaction. Effects of catalyst dosage, H2O2 concentration, initial concentration of the contaminants, and reaction time were evaluated. The results showed that MO and MB decomposition efficiencies were highly influenced by CuCo-ZIF concentration. The presence of H2O2 accelerated the degradation reaction of both MO and MB. Although it took 100 min to complete the removal of MB, it was 60 min for MO. At concentrations of MO and MB lower than 40 mg·L−1, the catalyst showed an almost complete degradation. The CuCo-ZIF catalyst presented a good recyclability with more than 90% removal of MO and MB after four times and five times reuse, respectively. These results demonstrated that MO and MB were efficiently degraded by a Fenton-like catalyst of CuCo-ZIFs and its potential in industrial wastewater treatment.
Industrial analytics – An overview
Authors: Gröger Christoph 
Published: January 2022

Abstract
The digital transformation generates huge amounts of heterogeneous data across the industrial value chain, from simulation data in engineering, over sensor data in manufacturing to telemetry data on product use. Extracting insights from these data constitutes a critical success factor for industrial enterprises, e. g., to optimize processes and enhance product features. This is referred to as industrial analytics, i. e., data analytics for industrial value creation. Industrial analytics is an interdisciplinary subject area between data science and industrial engineering and is at the core of Industry 4.0. Yet, existing literature on industrial analytics is fragmented and specialized. To address this issue, this paper presents a holistic overview of the field of industrial analytics integrating both current research as well as industry experiences on real-world industrial analytics projects. We define key terms, describe typical use cases and discuss characteristics of industrial analytics. Moreover, we present a conceptual framework for industrial analytics that structures essential elements, e. g., data platforms and data roles. Finally, we conclude and highlight future research directions.
Courts and Diversity: Normative Justifications and Their Empirical Implications
Authors: Weinshall Keren 
Published: January 2022

Abstract
The study distinguishes between three normative approaches that view diversity in the judiciary as a desirable ideal, outlines their expected empirical implications for judicial decision-making, and tests the implications against data from the Israeli Supreme Court. The “reflecting” approach suggests that diversifying the courts is important mainly as a means of strengthening the public’s confidence in them and does not impact judicial decisions. The “representing” approach asserts that judges serve as representatives of their social sectors. Thus, they tend to rule in favor of their group’s interest only in cases that are relevant to their in-group. The “social background theory” is based on the premise that people of different backgrounds develop distinct worldviews. Hence, social attributes are expected to influence judicial decisions across a wide range of socio-legal issues. The empirical investigation centers on the role of gender and religiosity in judging on five carefully selected socio-legal issues: petitions against the Great Rabbinical Court’s rulings, constitutional disputes in all legal procedures, social welfare cases, and criminal appeals in sex offenses and in drug offenses. The results lend support to social background theory with regard to gender and are consistent with the representing approach with respect to religiosity. I further discuss the limitations and policy implications of the findings.
Religious Courts and Rights in Plural Societies: Interlegal Gaps and the Need for Complex Concurrency
Authors: Neo Jaclyn L. 
Published: January 2022

Abstract
The administration or recognition of religious courts is a form of religious accommodation present in many constitutional states today commonly analysed in legal pluralism terms. This article contributes to the further analysis of the relationship between legal pluralism and rights in religiously diverse societies by examining the status of state religious courts and their interaction with state non-religious (secular) courts. In particular, I examine what Cover calls “jurisdictional redundancies” between the courts and conceptualize the allocation of power between religious and non-religious courts as a potentially productive site of interlegality. In doing so, I support concurrent jurisdictional allocations, arguing that exclusive jurisdiction could result in what I call an interlegal gap, whereby instead of inter-penetration of norms and production of reconciliatory principles, there is a justice gap whereby litigants may find themselves unable to obtain appropriate legal recourse including when neither court is willing to assume jurisdiction over the matter. This requires us to see the relationship between religious courts and non-religious courts through the more mundane but more practical lens of jurisdictional overlaps and competition, rather than through the more abstract framing of normative or even civilizational clashes. Accordingly, I argue that concurrent jurisdiction and interlegality have greater potential to strike a balance between individual and group rights and could be more protective of religious diversity. In other words, I argue for a closer, rather than a more separate, relationship between religious and non-religious courts, while denying that a hierarchical relationship where religious courts are subordinated to non-religious courts is the only way to protect rights.