bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of enzymolysis and fermentation on the antioxidant activity and functional components of a coarse cereal compound powder based on principal component analysis and microstructure study
Authors: Chen Yue , Chen Lan , Xiao Zhigang , Gao Lu 
Published: June 2022

AbstractIn this study, a coarse cereal compound powder (CCCP) was prepared through enzymolysis, fermentation, and joint treatment with 10 coarse cereal types as raw materials. Using 10 evaluation indices, namely the scavenging capacity of 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH•), 2,2′‐azino‐bis‐(3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS+), hydroxyl (OH•) and superoxide anion (O2–), the Fe2+ chelating capacity, the content of anthocyanin, flavone, soluble dietary fiber, reducing sugar and protein, antioxidant activity, and functional components of CCCP prepared by different methods were compared. Principal component analysis (PCA) was performed to establish a quality evaluation model of CCCP. Then, the effects of different treatments on the microstructure of CCCP were investigated. Two principal components (PCs) were extracted from PCA, with a cumulative contribution rate of 97.014%. In addition, the analysis of thermodynamic properties indicated that the initial gelatinization temperature of CCCP decreased after enzymolysis and fermentation and that it was easier to gelatinize. Particle size analyses revealed that different treatments could reduce the sample particles to different degrees. The average particle size in the three study groups decreased. Scanning electron microscopy (SEM) revealed that after different treatments, the samples were destroyed to different extents, which facilitated easy dissolution of active substances. Fourier‐transformed‐infrared spectroscopy (FTIR) revealed that the changes of CCCP functional groups after fermentation and joint treatment were more significant than those after enzymolysis.Practical ApplicationIn this study, enzymolysis and fermentation techniques were used to improve the antioxidant activity and functional components of CCCP, and the effects of different treatments on the microstructure of CCCP were investigated. The bioavailability and nutrient composition of CCCP could be significantly improved by pretreatment, provide useful reference for the development of beneficial ingredients in cereal meal products and the application of different pretreatment methods.
Transcript‐ and annotation‐guided genome assembly of the European starling
Authors: Stuart Katarina C. , Edwards Richard J. , Cheng Yuanyuan , Warren Wesley C. , Burt David W. , Sherwin William B. , Hofmeister Natalie R. , Werner Scott J. , Ball Gregory F. , Bateson Melissa , Brandley Matthew C. , Buchanan Katherine L. , Cassey Phillip , Clayton David F. , De Meyer Tim , Meddle Simone L. , Rollins Lee A. 
Published: June 2022

AbstractThe European starling, Sturnus vulgaris, is an ecologically significant, globally invasive avian species that is also suffering from a major decline in its native range. Here, we present the genome assembly and long‐read transcriptome of an Australian‐sourced European starling (S. vulgaris vAU), and a second, North American, short‐read genome assembly (S. vulgaris vNA), as complementary reference genomes for population genetic and evolutionary characterization. S. vulgaris vAU combined 10× genomics linked‐reads, low‐coverage Nanopore sequencing, and PacBio Iso‐Seq full‐length transcript scaffolding to generate a 1050 Mb assembly on 6222 scaffolds (7.6 Mb scaffold N50, 94.6% busco completeness). Further scaffolding against the high‐quality zebra finch (Taeniopygia guttata) genome assigned 98.6% of the assembly to 32 putative nuclear chromosome scaffolds. Species‐specific transcript mapping and gene annotation revealed good gene‐level assembly and high functional completeness. Using S. vulgaris vAU, we demonstrate how the multifunctional use of PacBio Iso‐Seq transcript data and complementary homology‐based annotation of sequential assembly steps (assessed using a new tool, saaga) can be used to assess, inform, and validate assembly workflow decisions. We also highlight some counterintuitive behaviour in traditional busco metrics, and present buscomp, a complementary tool for assembly comparison designed to be robust to differences in assembly size and base‐calling quality. This work expands our knowledge of avian genomes and the available toolkit for assessing and improving genome quality. The new genomic resources presented will facilitate further global genomic and transcriptomic analysis on this ecologically important species.
Autopsy case of a patient with rapidly progressive combined small‐cell lung carcinoma with spindle‐shaped cell tumor
Authors: Morimoto Toshiki , Yamasaki Kei , Shingu Tatsuya , Sato Tomoki , Uryu Takumu , Jotatsu Takanobu , Kato Kaori , Kawabata Hiroki , Nishida Chinatsu , Yatera Kazuhiro 
Published: June 2022

AbstractA 69‐year‐old Japanese man visited our hospital because of worsening shortness of breath. His chest computed tomography (CT) showed a giant left lung mass with a massive left pleural effusion. He could not be treated with chemotherapy and eventually died from a rapidly progressive tumor. He was diagnosed with combined small cell lung carcinoma (C‐SCLC) with spindle‐shaped cell tumor at autopsy. C‐SCLC is characterized by pathologically concurrent SCLC and adenocarcinoma or squamous cell carcinoma, or rarely, spindle‐shaped cell tumor. The clinical course of C‐SCLC with spindle‐shaped cell tumor has not previously been determined. Our patient's tumor increased by 2.59‐fold in 20 days. The combination of C‐SCLC with spindle‐shaped cell tumor suggested rapid progression and a poor prognosis.
Is no news bad news? The impact of disclosing COVID‐19 tracing information on consumer dine out decisions
Authors: Gao Yuan , Lopez Rigoberto A. , Liao Ruili , Liu Xiaoou 
Published: June 2022

AbstractFood markets around the world have been disrupted by the COVID‐19 pandemic via consumer behavior upended by fear of infection. In this article, we examine the impact of disclosing COVID‐19 contact tracing information on food markets, using the restaurant industry in China as a case study. By analyzing transaction data at 87 restaurants across 10 cities, we estimate difference‐in‐difference (DID) models to ascertain the impact of COVID‐19 infections and contact information tracing on economic activity as measured by a daily number of transactions. Empirical results show that while the overall number of new COVID‐19 infections at the national level caused a dramatic drop in numbers of transactions in all restaurants, restaurants in cities that disclosed contact tracing information of COVID‐19 infections experienced a 23%–35% higher number of transactions than the ones in cities that did not disclose such information during the recovery period. Ultimately, we show that in the absence of a shelter‐in‐place mandate, disclosing contract tracing information to mitigate consumers’ uncertainties about risks of being infected can contribute to a faster recovery of food markets, in addition to reducing COVID‐19 infections.
Rapid review and meta‐analysis of adverse events associated with molnupiravir in patients with COVID‐19
Authors: Amani Behnam , Zareei Sara , Amani Bahman 
Published: June 2022

AimsThe aim of this study was to evaluate the safety profile of molnupiravir in COVID‐19 patients.MethodsPubMed, Cochrane Library, medRxive and Google Scholar were searched for articles published up to April 25, 2022. Meta‐analysis was performed using Comprehensive Meta‐Analysis software.ResultsFour trials involving 2241 patients met the inclusion criteria. No significant difference was observed between molnupiravir at 200, 400 and 800 mg compared with placebo (200 mg: risk ratio [RR] = 0.97; 95% confidence interval [CI]: 0.78–1.20; P = .80; 400 mg: RR = 0.81; 95% CI: 0.64–1.02; P = .07; 800 mg: RR = 0.94; 95% CI: 0.83–1.06; P = .36) for any adverse events (AEs); at 200, 400 and 800 mg compared with placebo (200 mg: RR = 0.81; 95% CI: 0.41–1.63; P = .57; 400 mg: RR = 0.82; 95% CI: 0.41–1.61; P = .56; 800 mg: RR = 0.80; 95% CI: 0.59–1.08; P = .15) for serious adverse events; at 200, 400 and 800 mg compared with placebo (200 mg: RR = 1.74; 95% CI: 0.48–6.30; P = .39; 400 mg: RR = 1.07; 95% CI: 0.28–4.09; P = .91; 800 mg: RR = 0.47; 95% CI: 0.17–1.28; P = .14) for AEs leading to death; and at 200, 400 and 800 mg compared with placebo (200 mg: RR = 1.50; 95% CI: 0.26–8.55; P = .64; 400 mg: RR = 0.99; 95% CI: 0.17–5.68; P = .99; 800 mg: RR = 0.61; 95% CI: 0.31–1.23; P = .17) for treatment discontinuation due to AEs.ConclusionThis meta‐analysis showed that the use of three doses of molnupiravir (200, 400 and 800 mg) is safe for COVID‐19 patients. Further research is needed to confirm the present findings.
The association between maternal perinatal mental health and perfectionism: A systematic review and meta‐analysis
Authors: Evans Clare , Kreppner Jana , Lawrence Peter J. 
Published: June 2022

AbstractBackgroundPerfectionism is an important feature of adult psychopathology. In the absence of a prior review of the role of perfectionism in perinatal psychopathology, we aimed to ascertain whether perfectionism was associated with symptoms of maternal perinatal depression and anxiety.MethodWe followed PRISMA guidance (PROSPERO: 42019143369), estimated weighted effect sizes and tested possible moderators: timing (pre or post‐ natal), scales used to measure constructs, infant gender, temperament and age; and rated study quality.ResultsFourteen studies met eligibility criteria. Perfectionism as a whole, and the perfectionistic concerns dimension, were moderately correlated with common maternal perinatal mental health difficulties r = .32 (95% Confidence Interval = 0.23 to 0.42). In sub‐group analyses, perfectionistic concerns were associated with depression (r = .35, 95% CI = 0.26–0.43). We found no evidence of significant moderation of associations.LimitationsIncluded studies had methodological and conceptual limitations. All studies examined depression and two examined anxieties; all examined perfectionistic concerns and four examined perfectionist strivings.ConclusionsPerfectionism, namely perfectionistic concerns, is potentially associated with common maternal perinatal mental health problems. While further research is warranted, identification of perfectionism in the perinatal period may help focus resources for intervention, reducing the prevalence of perinatal mental health difficulties.
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation
Authors: Su Hang , Mei Yu , Luo Shuangxue , Wu Haixia , He Yan , Shiraishi Yasunaga , Hu Pingping , Cohen Richard A. , Tong Xiaoyong 
Published: June 2022

Background and PurposeThe cysteine674 (C674) thiol of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 is easily and irreversibly oxidized under atherosclerotic conditions. However, the contribution of the C674 thiol redox status in the development of atherosclerosis remains unclear. Our goal was to elucidate the possible mechanism involved.Experimental ApproachHeterozygous SERCA2 C674S knock‐in mice in which half of the C674 was substituted by serine (S674) were used to mimic the removal of the reactive C674 thiol, which occurs under pathological conditions. Bone marrow‐derived macrophages (BMDMs) and cardiac endothelial cells (ECs) were used for intracellular Ca2+, macrophage adhesion, and protein expression analysis. The whole aorta and aortic root were isolated for histological analysis.Key ResultsCell culture studies suggest the partial substitution of SERCA2 C674 increased intracellular Ca2+ levels and induced ER stress in both BMDMs and ECs. The release of proinflammatory factors and macrophage adhesion increased in SKI BMDMs. In ECs, overexpression of S674 induced endothelial inflammation and promoted macrophage recruitment. SKI mice developed more severe atherosclerotic plaque and macrophage accumulation. Additionally, 4‐phenyl butyric acid, an ER stress inhibitor, suppressed ER stress and inflammatory responses in BMDMs and ECs, and alleviated atherosclerosis in SKI mice.Conclusions and ImplicationsThe substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. Our findings highlight the importance of SERCA2 C674 redox state in the context of atherosclerosis and open up a novel therapeutic strategy to combat atherosclerosis.
Buccal soft tissue dehiscence defects at dental implants—associated factors and frequency of occurrence: A systematic review and meta‐analysis
Authors: Sanz‐Martín Ignacio , Regidor Erik , Cosyn Jan , Wiedemeier Daniel B. , Thoma Daniel S. 
Published: June 2022

AbstractAimTo identify the factors associated with buccal peri‐implant soft tissue dehiscences (BSTDs) and their frequency of occurrence.Materials and MethodsRandomized controlled trials, controlled clinical trials, cohort studies, and case series assessing the frequency of occurrence of BSTD were included. BSTD was defined as an apical migration of the peri‐implant soft tissues of ≥1 mm from the baseline examination (final restoration) or in comparison with the adjacent or contralateral natural tooth. Frequency distributions of BSTD related to the presence or absence of any surgical, prosthetic, or anatomic factor that may have contributed to the development of BSTD were recorded. Random‐effects meta‐analyses using odds ratios (OR) were performed to investigate the association of certain factors with the development of BSTD.ResultsTwenty‐four articles were finally included belonging to 22 clinical investigations. Patients at higher risk of developing BSTD were associated with thin biotype (OR = 2.85 [1.40, 5.8], n = 5, p = .003) and with buccally placed implants (OR = 14.37 [4.58, 45.14], n = 3, p ≤ .001). Patients without connective tissue grafting (CTG) had greater odds of developing BSTD (OR = 9.00 [3.11, 26.02], n = 5, p ≤ .001), while buccal bone plate thickness of <1 mm and immediately placed implants were not associated with greater BSTD (OR = 1.29 [0.35, 4.77], n = 2, p = .704 and OR = 1.56 [0.46, 5.26], n = 4, p = .477, respectively). The frequency of occurrence of BSTD varied across the included studies with a range from 0% to 61%.ConclusionsThin tissue biotype and buccally placed implants were associated with BSTD, whereas CTG seemed to have a protective effect. Thin buccal plates and immediately placed implants did not demonstrate a higher risk of BSTD.
Efficacy of soft tissue augmentation procedures on tissue thickening around dental implants: A systematic review and meta‐analysis
Authors: Valles Cristina , Vilarrasa Javi , Barallat Lucía , Pascual Andrés , Nart Jose 
Published: June 2022

AbstractObjectivesThe first focused question (FQ1) was: What is the efficacy of connective tissue graft (CTG), as compared to the absence of soft tissue grafting procedure, in terms of gain in peri‐implant soft tissue thickness (STT) reported by randomized controlled clinical trials (RCTs) or controlled clinical trials (CCTs)? The second focused question (FQ2) was: What is the efficacy of CTG, as compared to soft tissue substitutes, in terms of gain in peri‐implant STT reported by RCTs or CCTs?Materials and methodsA manual and electronic search was performed for each question to identify RCTs and CCTs published up to July 2020. The primary outcome variable was changes in peri‐implant STT and secondary outcomes were marginal bone level (MBL), clinical parameters for the diagnosis of peri‐implant health, changes in the position of peri‐implant soft tissues, esthetic outcomes, and patient‐related outcome measures (PROMs). For primary and secondary outcomes, data reporting mean values and standard deviations for each study were extracted. Weighted mean differences (WMDs) or standardized mean differences as well as 95% confidence intervals (CIs) and prediction intervals (PIs) were calculated.ResultsEight trials were included to answer the first focused question and eight to answer the second one, providing data for 254 and 192 patients, respectively. For the first focused question, a statistically significant difference of 0.64 mm in STT was found in favor of the grafted group (n = 8; 95% CI [0.16; 1.13]; 95% PI [−1.06; 2.35]; p = .01). Moreover, sites treated with CTG exhibited statistically significant less recession than implants without a graft (n = 4; WMD = 0.50 mm; 95% CI [0.19; 0.80]; 95% PI [−0.70; 1.69]; p < .001). For the second focused question, the meta‐analysis showed a statistically significant gain of STT in the CTG group when compared to soft tissue substitutes (n = 8; WMD = 0.51 mm; 95% CI [0.28; 0.75]; 95% PI [−0.09; 1.12]; p < .001). Furthermore, the use of CTG resulted in significantly higher pink esthetic score values (n = 3; WMD = 1.02; 95% CI [0.29; 1.74]; 95% PI [−3.67; 5.70]; p = .01) and less recession (n = 2; WMD = 0.50 mm; 95% CI [0.10; 0.89]; 95% PI [not estimable]; p = .014) when compared to soft tissue substitutes. No statistically significant differences between groups were observed for any of the following secondary variables: MBL, clinical parameters for the diagnosis of peri‐implant health, position of the interproximal tissues, keratinized mucosa or PROMS (p > 0.05), except for medication intake, which was significantly higher when using CTG as compared to soft tissue substitutes (n = 2; WMD = 1.68; 95% CI [1.30; 2.07]; 95% PI [not estimable]; p < .001).ConclusionsSoft tissue augmentation procedures are efficacious on soft tissue thickening and, in particular, CTG demonstrated a significant STT gain when compared to no graft or soft tissue substitutes.
Can we HALT obesity following lung transplant? A Dietitian‐ and Physiotherapy‐directed pilot intervention
Authors: Emsley Christie , Snell Greg , Paul Eldho , Fuller Louise , Paraskeva Miranda , Nyulasi Ibolya , King Susannah 
Published: June 2022

AbstractIntroductionUnintentional weight gain, overweight and obesity following solid organ transplantation (SOT) are well‐established and linked to morbidity and mortality risk factors. No interventional studies aimed at prevention have been undertaken among lung transplant (LTx) recipients. The combination of group education and telephone coaching is effective in the general population but is untested among SOT cohorts.MethodsA non‐randomized, interventional pilot study was conducted among new LTx recipients. The control group received standard care. In addition to standard care, the intervention involved four group education and four individual, telephone coaching sessions over 12‐months. Data collection occurred at 2 weeks, 3‐ and 12 months post‐LTx. Measurements included weight, BMI, fat mass (FM), fat mass index (FMI), fat‐free mass (FFM), fat‐free mass index (FFMI), waist circumference (WC), visceral adipose tissue (VAT), nutrition knowledge, diet, physical activity, lipid profile, HbA1C, FEV1, six‐minute walk distance and patient satisfaction.ResultsFifteen LTx recipients were recruited into each group. One control participant died 120 days post‐LTx, unrelated to the study. There were trends towards lower increases in weight (6.7±7.2 kg vs. 9.8±11.3 kg), BMI (9.6% of baseline vs. 13%), FM (19.7% vs. 40%), FMI, VAT (7.1% vs. 30.8%) and WC (5.5% vs. 9.5%), and greater increases in FFM and FFMI (all P > .05), among the intervention group by 12 months. The intervention was well‐accepted by participants.ConclusionThis feasible intervention demonstrated non‐significant, but clinically meaningful, favorable weight and body composition trends among LTx recipients over 12 months compared to standard care.
Looking Again and Beyond: The Power of Images in Intercultural Training in Youth Mental Health Care
Authors: Johnson‐Lafleur Janique 
Published: June 2022

AbstractThis article explores the role of images in intercultural training in youth mental health care. Drawing on ethnographic work conducted with practitioners taking part in transcultural seminars, this article discusses how the attention paid to images during these meetings can enable practitioners to adopt a different way of looking at the families they work with. To do so, I draw from the writings of theorists who have reflected on how images work and the power they can have over us. I first turn to the Barthian notion of punctum, and then to Kaja Silverman's argument on the role of the aesthetic object in “educating our look.” Through an ethnographic vignette, I describe how images flow during a meeting and impact the people present. I argue that working with images in intercultural training is more productive in transforming the colonial gaze than making theoretical statements that trainees may interpret as judgmental.
Receptor density influences the recruitment bias of aripiprazole and brexpiprazole at the dopamine D2L receptor
Authors: Ferraiolo Mattia , Ponthot Romane , Atik Hicham , Koener Beryl , Hanson Julien , Hermans Emmanuel 
Published: June 2022

AbstractAripiprazole, brexpiprazole, and cariprazine are dopamine D2 receptor ligands considered as effective and tolerable antipsychotics. Brain imaging studies showed that schizophrenia is characterized by elevated dopamine receptor density, which is exacerbated by antipsychotic treatments. Despite the complexity of translating in vitro studies to human neurobiology, overexpression experiments in transfected cells provide a proof‐of‐concept model of the influence of receptor density on antipsychotic treatments. Since receptor density was demonstrated to influence the signaling profile of dopaminergic ligands, we hypothesized that high dopamine D2 receptor expression levels could influence the recruitment of Gi1 and β‐arrestin2 in response to partial agonists used as antipsychotics. A nanoluciferase complementation assay was used to monitor β‐arrestin2 and Gi1 recruitment at the dopamine D2L receptor in response to aripiprazole, brexpiprazole, and cariprazine. This was performed in transfected cells carrying a doxycycline‐inducible system allowing to manipulate the expression of the dopamine D2L receptors. Increasing D2L receptor density reoriented aripiprazole's preferential recruitment from Gi1 to β‐arrestin2. With respect to brexpiprazole, which showed inverse agonism for β‐arrestin2 recruitment at the lower receptor density tested, inverse agonism for Gi1 recruitment was observed when tested at a high receptor expression level. At variance, cariprazine evoked a potent partial agonism for β‐arrestin2 recruitment only, in all the tested conditions. D2L receptor density appears to shape the recruitment bias of aripiprazole and brexpiprazole, but not cariprazine. This suggests that changes in receptor expression level could qualitatively influence the functional response of partial agonists used in psychiatry.