bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy of chitosan‐based hydrocolloid dressing in the treatment of chronic refractory wounds
Authors: Liu Jing , Shen Hong 
Published: May 2022

AbstractThis retrospective study aimed to explore the clinical efficacy of chitosan‐based hydrocolloid dressing in treating chronic refractory wounds. A total of 80 patients with chronic refractory wounds were randomly divided into the control group (n = 40) and the study group (n = 40). The control group was given inert saline gauze, while the study group was given chitosan‐based hydrocolloid dressing. After 3 weeks of treatment, the wound healing efficiency, itching pain score, changes in the wound area, dressing change frequency, and cost were measured. There was a significant difference in the wound healing effect (t = 2.738), and degree of pain (t = 4.76) between the study and control groups, after 3 weeks of treatment. Similarly, a prominent reduction in the itching frequency (t = 8.62), and wound area (t = 6.379) was observed in the study group compared to the control group (P < .05). Moreover, the frequency and total cost of dressing change in the study group were also lower than the control group and the difference was statistically significant (P < .05). To summarise, the application of chitosan‐based hydrocolloid dressing in treating chronic refractory can effectively alleviate pain, accelerate wound healing, relieve itching pain, and reduce the overall cost and frequency of dressing change.
Effect of chitosan‐based gel dressing on wound infection, synechia, and granulations after endoscopic sinus surgery of nasal polyps: A meta‐analysis
Authors: Liu Ruyang , Gong Zheng 
Published: May 2022

AbstractA meta‐analysis was performed to evaluate the effect of chitosan‐based gel dressing on wound infection, synechia, and granulations after endoscopic sinus surgery of nasal polyps. A systematic literature search until March 2022 incorporated 386 subjects after endoscopic sinus surgery of nasal polyps at the beginning of the study; 187 were using chitosan‐based gel dressing, and 199 were control. Statistical tools like the dichotomous method were used within a random or fixed‐influence model to establish the odds ratio (OR) with 95% confidence intervals (CIs) to evaluate the influence of chitosan‐based gel dressing on wound infection, synechia, and granulations after endoscopic sinus surgery of nasal polyps. Chitosan‐based gel dressing had significantly lower wound infection (OR, 0.48; 95% CI, 0.25–0.92, P = 0.03), and synechia (OR, 0.25; 95% CI, 0.13–0.50, P < 0.001) compared with control in subjects with endoscopic sinus surgery of nasal polyps. However, no significant difference was found in granulations between chitosan‐based gel dressing and control in subjects with endoscopic sinus surgery of nasal polyps. Chitosan‐based gel dressing had significantly lower wound infection, synechia compared with control in subjects with endoscopic sinus surgery of nasal polyps, and no significant difference in granulations. Further studies are required to validate these findings.
Portfolio Literacy and the Transition to Work for Graphic Design Graduates
Authors: Barnes Carolyn , Wragg Nicole , Fisher Emma , Tyagi Shivani , de Kruiff Alison 
Published: May 2022

AbstractThe graphic design industry has moved beyond its traditional focus on printed matter to deliver multidimensional communication projects involving diverse audiences and media channels. No longer a skills and service industry, graphic design increasingly informs business strategy and innovation processes, requiring heterogeneous expertise, a rigorous design process and the ability to work in multidisciplinary teams. This shift raises the question of the relevance of a traditional design portfolio in demonstrating employability, especially when employers prioritise generic over disciplinary and technical skills. Our article reports the results of a survey of 53 Australian employers of graphic design graduates on the role of the portfolio in evidencing design‐specific and more general employability skills, capacities and attributes. The article provides a deeper understanding of the role of a portfolio in the transition to work. We argue that graphic design graduates need ‘portfolio literacy’—which combines insight in the curation of the portfolio and its use in interview performance—to demonstrate both core graphic design and creative skills and capacities in communication, collaboration and problem‐solving. This significant know‐how is best developed during graduates’ tertiary studies.
Use of extendable helix leads for conduction system pacing: Differences in lead handling and performance lead design impacts conduction system pacing
Authors: Tan Eugene S. J. , Lee Jie‐Ying , Boey Elaine , Soh Rodney , Sim Ming G. , Yeo Wee‐Tiong , Seow Swee‐Chong , Kojodjojo Pipin 
Published: May 2022

AbstractIntroductionPacing leads with extendable‐retractable helix (EHL) are alternatives to fixed‐helix leads (FHL) for conduction system pacing (CSP), but data on handling characteristics are limited. This study evaluated a dual‐center experience of lead handling and performance during CSP.Methods and ResultsConsecutive patients with His‐bundle pacing (HBP) or left bundle branch pacing (LBBP) were evaluated for the primary outcome of lead failure, defined as structural damage to the lead necessitating lead replacement. Differences in pacing characteristics were compared. Among 280 patients (mean age 74 ± 11 years, 44% male, 50% LBBP), 246 (88%) received FHL and 34 (12%) received EHL. Of 299 leads used, lead failure occurred more frequently among patients with EHL than FHL (29% vs. 2%, p < .001), regardless of CSP modality. Majority of damaged leads (89%) in the form of helix deformation were successfully removed, with failure occurring in only two patients, both EHL, leading to helix fracture and retention within the septal myocardium. EHL, compared to FHL, was associated with 25‐fold increased odds of lead failure (odds ratio: 25.21, 95% confidence interval: 7.35–86.51), and persisted after adjustment in turn for age, pacing modality and indication. CSP implant success rates did not differ by lead design (FHL 80% vs. EHL 71%, p = .18), with similar pacing thresholds at implant and follow‐up.ConclusionHelix deformation and fracture were more frequent with EHL in CSP despite similar implant success. These findings have significant implications for lead selection during CSP and raises concerns about the long‐term extractability of EHL in CSP.
Solasonine induces apoptosis of the SGC‐7901 human gastric cancer cell line in vitro via the mitochondria‐mediated pathway
Authors: Li Tian‐Chuan , Chen Nai‐Jie , Chen Yun‐Ying , He Bing‐Jing , Zhou Zhi‐Feng 
Published: May 2022

AbstractSolasonine, a steroidal glycoalkaloid isolated from the herbal plant Solanum nigrum Linn., has shown active against multiple human cancers; however, there is little knowledge on the activity of solasonine against gastric cancer until now. This study aimed to examine the effect of solasonine on the biological behaviours of human gastric cancer SGC‐7901 cells. The results showed that solasonine suppressed SGC‐7901 cell proliferation in a dose‐dependent manner. Solasonine treatment mainly induced the cell cycle arrest at G2 phase in SGC‐7901 cells. Treatment with solasonine resulted in significant down‐regulation of Bcl‐2 and Caspase‐3 protein expression and reduced Bax and Bcl‐xL protein expression in SGC‐7901 cells. Solasonine shows a comparable inhibitory effect on the proliferation of human gastric cancer SGC‐7901 cells with cisplatin, and solasonine induces of SGC‐7901 cell apoptosis through triggering the endoplasmic reticulum stress pathway and the mitochondrial pathway. Our data indicate that solasonine may be a promising agent for the treatment of gastric cancer.
Commentary: Suicide risk is high, but often overlooked, in autistic spectrum disorder populations
Authors: Curtis Luke 
Published: May 2022

Self‐Harm Significantly Higher in Populations with ADHD, Anxiety, ASD, Depression, and Eating Disorders. I appreciated your recent paper on the large and well‐matched studies on nonfatal self‐harm and suicide among adolescents in the UK Clinical Practice Research Datalink (Cybulski et al. 2021). This large study involved 56,008 self‐harm cases and 1,399,356 controls aged 10–19 years and reported that many diagnoses were associated with significantly higher rates of self‐harm. Compared to controls, the risk of self‐harm was significantly higher in attention‐deficit/hyperactivity disorder (ADHD) (OR 3.3, 95% CI 3.1–3.4), anxiety disorder (OR 3.8, 95% CI 3.7–3.9), autism spectrum disorder (ASD) (OR 2.4, 95% CI 2.3–2.6), depression (OR 7.9, 95% CI 7.8–8.2), and eating disorders (OR 3.1, 95% CI 3.0–3.2) (Cybulski et al. 2021).
Substitution of telemedicine for clinic visit during the COVID‐19 pandemic of 2020: Comparison of telemedicine and clinic visit
Authors: Onishi Yukiko , Ichihashi Rieko , Yoshida Yoko , Tahara Tazu , Kikuchi Takako , Kobori Toshiko , Kubota Tetsuya , Iwamoto Masahiko , Hamano Shoko , Kasuga Masato 
Published: May 2022

ABSTRACTAims/IntroductionThe purpose of this retrospective observational cohort study was to compare outpatient diabetes care and glycated hemoglobin (HbA1c) level during the coronavirus disease 2019 pandemic in 2020 with 2019, and to compare the glucose‐lowering effect of telemedicine and clinic visits during the state of emergency in Japan declared from 7 April to 25 May (inter‐period) 2020.Materials and MethodsA total of 13 weeks before and after the inter‐period were designated as the pre‐period and post‐period, respectively. The number of study participants who had clinic visits during the pre‐period and the post‐period were 3,333 in 2020 and 3,608 in 2019. Propensity score matching was carried out to compare the effect of telemedicine and clinic visits on diabetes control in 2020 among diabetes patients with insufficient glucose control (HbA1c ≥7%). The primary outcome was post‐period HbA1c.ResultsThe major difference between 2020 and 2019 was the use of telemedicine in 2020. After adjustment for age, sex, diabetes type, pre‐period HbA1c and pre‐period body mass index, glycemic control evaluated by HbA1c was significantly worse in the post‐period of 2020 than 2019. In the propensity score‐matched 618 pairs, the clinic visit group had significantly better post‐period HbA1c than the telemedicine group (7.5% vs 7.4%, P = 0.023).ConclusionsGlycemic control was slightly, but significantly, worse in 2020 than 2019. Although telemedicine significantly improved glycemic control during the coronavirus disease 2019 pandemic in 2020, clinic visits improved HbA1c significantly more. The substitution of telemedicine for clinic visits appears to be a viable option under emergency conditions, but clinic visits might be a better option when possible.
Re‐description of the loach species Homatula variegata (Dabry de Thiersant, 1874) (Pisces: Nemacheilidae) from the middle Huang‐He basin in Shaanxi Province of Central China
Authors: Liu Yi , Cao Liang , Zhang E. 
Published: May 2022

AbstractDespite the wide recognition of Homatula variegata (Dabry de Thiersant, 1874) as a valid Chinese loach, its type locality, identity and distribution still remain contentious. A molecular phylogenetic analysis based on the mitochondrial cytochrome b (cyt b) gene for samples from all known range of the species showed that three distinct species are involved. Morphological comparisons, coupled with examination on the types, confirmed that H. variegata s. str. is characterized by having a sparsely scaled predorsal body, an adipose crest along the dorsal midline of the caudal peduncle that extends forward to the vertical through the posterior end of the anal‐fin base and a broadly rounded caudal fin. It is found merely in the Wei‐He of the Huang‐He basin. The Jinsha‐Jiang population, previously misidentified as H. variegata, represents a distinct species, for which Homatula oxygnathra is the available name. Homatula laxiclathra, endemic to the Wei‐He, is also a valid species distinct from H. variegata.
Reduction of scour around circular piers using collars
Authors: Pandey Manish , Pu Jaan H. , Pourshahbaz Hanif , Khan Mohammad Amir 
Published: May 2022

AbstractRiver dynamics and sediment transport play an important role in river bed morphology. Building a bridge pier along the river alters the cross‐section of the river and causes the change in flow processes. These changes are mainly responsible for pier scour. In this paper, the usage of collars to reduce scour around circular piers has been investigated. The collars with different diameters and depth positions have been studied using previous data and additional data collected in the present study to assess their effectiveness in reducing scour. Using a wide range of measured data, an empirical equation to compute the maximum scour depth around the circular piers in the presence of collars has been proposed. The proposed equation has been validated and proven to be applicable to a wide range of pier layouts. It has been found that the maximum efficiency can be achieved by fixing the collar at bed level and adopting a collar diameter 1.5–2.5 times of pier diameter.
Association between staff turnover and nursing home quality – evidence from payroll‐based journal data
Authors: Zheng Qing , Williams Christianna S. , Shulman Evan T. , White Alan J. 
Published: May 2022

AbstractBackgroundStaff turnover is considered an important indicator of nursing home quality. We used auditable staffing data from the Centers for Medicare & Medicaid Services (CMS) Payroll‐Based Journal (PBJ) system to calculate turnover measures for nurse staff and administrators and examined the relationship between turnover and nursing home quality.MethodsOur analyses included data from 13,631 nursing homes that submitted complete staffing data through PBJ for 2018Q3 – 2019Q4. We identified turnover based on gaps in days worked by eligible employees, allowing us to calculate turnover measures that do not depend on termination dates reported by nursing homes, which are not captured in PBJ.We linked staff turnover measures to nursing home quality measures and star ratings published on CMS' Care Compare website in January 2020 and examined the relationship between turnover and quality of care. We used ordinary least squared models for continuous outcomes and ordered logit models for categorical outcomes, controlling for facility, and county characteristics.ResultsMean annual turnover rates were about 44% for RNs and 46% for total nurse staff. On average, there was one administrator leaving each nursing home during this period although about half of nursing homes had no administrator turnover.Turnover rates varied greatly across nursing homes. For‐profit and larger nursing homes had higher turnover rates. Higher turnover was consistently associated with lower quality of care.ConclusionsOur study highlights the importance of staff turnover due to its relationship to nursing home quality. In January 2022, CMS started posting turnover measures on Care Compare to allow consumers to use this information in their assessment of nursing home quality and to motivate nursing homes to implement innovative strategies to retain staff. While these actions are challenging, they are nonetheless warranted for improving the quality of care for nursing home residents.
UBA domain protein SUF1 interacts with NatA‐complex subunit NAA15 to regulate thermotolerance in Arabidopsis
Authors: Song Ze‐Ting , Chen Xiao‐Jie , Luo Ling , Yu Feifei , Liu Jian‐Xiang , Han Jia‐Jia 
Published: May 2022

SummaryDuring recovery from heat stress, plants clear away the heat‐stress‐induced misfolded proteins through the ubiquitin‐proteasome system (UPS). In the UPS, the recognition of substrate proteins by E3 ligase can be regulated by the N‐terminal acetyltransferase A (NatA) complex. Here, we determined that Arabidopsis STRESS‐RELATED UBIQUITIN‐ASSOCIATED‐DOMAIN PROTEIN FACTOR 1 (SUF1) interacts with the NatA complex core subunit NAA15 and positively regulates NAA15. The suf1 and naa15 mutants are sensitive to heat stress; the NatA substrate NSNC1 is stabilized in suf1 mutant plants during heat stress recovery. Therefore, SUF1 and its interactor NAA15 play important roles in basal thermotolerance in Arabidopsis.
Editorial: Exciting developments in neurochemistry research and publishing
Authors: Lawrence Andrew J. , Prado Marco A. 
Published: May 2022

AbstractIn this editorial, we are happy to connect with our community to explain the changes introduced to the Journal of Neurochemistry over the last year and provide some insights into new developments and exciting opportunities. We anticipate these developments, which are strongly guided to increase transparency and support early career researchers, will increase the value of the Journal of Neurochemistry for the authors and readers. Ultimately, we hope to improve the author experience with the Journal of Neurochemistry and continue to be the leading venue for fast dissemination of exciting new research focusing on how molecules, cells and circuits regulate the nervous system in health and disease.
The Effect of Finishing and Polishing with Proprietary Vs Interchanged Polishing Kits on the Surface Roughness of Different Ceramic Materials
Authors: Irusa Karina F , Albouy Jean‐Pierre , Cook Ryan , Amaya‐Pajares Silvia , Donovan Terence 
Published: May 2022

AbstractPurposeTo evaluate the surface roughness of glazed and polished monolithic ceramic materials and to use this as a baseline for comparison after adjustment and polishing with both the recommended kit for the specific materials as well as interchanged polishing kits.Material and methodsFlat ceramic specimens (n = 150) were fabricated from IPS ZirCAD Prime, IPS E.max, and Vitabloc Mark II. The specimens were adjusted and polished using either the proprietary polishing kit for the material or interchanged kits. The surface roughness was objectively assessed using Atomic Force Microscopy (AFM) and profilometer. Subjective assessment of surface finish was performed using a scanning electron microscope (SEM). Gravimetric weight loss of each sample was measured before and after polishing using a digital microscale. The mean surface roughness and standard deviation was calculated for each ceramic‐ polisher pair. A factorial ANOVA was used to compare the mean surface roughness values in nanometers between multiple groups (α = 0.05). The subjective results from the SEM were reported as descriptive statisticsResultsThe zirconia polishing system produced surfaces with the lowest surface roughness regardless of the ceramic material. The polisher‐ceramic combination was found to have a statistically significant effect on both Ra and RMS values when the AFM was used (p = 0.039 and 0.010, respectively).ConclusionThe zirconia polishing system resulted in the lowest surface roughness values regardless of ceramic materials tested. The zirconia polishing system also did not result in significant gravimetric weight loss regardless of the ceramic material used.
The risk factors of preterm birth: A multicentre case–control survey in China in 2018
Authors: Zhang Yi‐Jie , Shen Jieru , Lin Sam Bill , Lu Chengqiu , Jiang Hong , Sun Yi , Cheng Xiuyong , Wang Huaiyan , Cui Shudong , Liu Xiuqin , Huang Lie , Lin Xinzhu , Zhao Guoying , Yang Ling , Chen Chao 
Published: May 2022

ObjectivesTo investigate the risk profile of preterm birth (PTB) in 2018 in China.MethodA prospective multicentre case–control study was conducted in 15 hospitals located in seven provinces throughout three geographical areas (the Eastern, South‐Central and North‐Western regions) in China. A total of 3147 preterm (<37+0 weeks) and 3147 term (37+0 to 41+6 weeks) live‐birth mothers were included. Designed questionnaires were used to investigate maternal and fetal information. We calculated multivariable logistic regression and population attributable risk (PAR).ResultsIatrogenic PTB accounted for 48.1% of preterm mothers. Multivariable analysis showed PTB was significantly associated with six categories of maternal and fetal factors, adverse life‐style and psychological conditions (adjusted odds ratio (aOR) 2.063, 95% confidence interval (CI) 1.601–2.657) had the highest PAR% (60.1%). High school and below education level (PAR% = 25.8%), living in town or village (PAR% = 24.4%), low pregnant weight gain (PAR% = 16.8%), hypertensive disorders in pregnancy (aOR: 5.010, 95% CI: 4.039–6.216, PAR% = 15.3%), placental abnormality (aOR: 4.242, 95% CI: 3.454–5.211, PAR% = 14.1%) and multiple pregnancy (aOR: 10.990, 95% CI: 7.743–15.599, PAR% = 11.8%) were significantly associated with PTB with high PAR% value.ConclusionThe main risk factors for PTB in China were placental abnormality, hypertensive disorders in pregnancy and multiple pregnancy. Adverse life‐style and psychological conditions and socio‐economic disadvantage had high public health significance.
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium
Authors: Bartolini Desirée , Arato Iva , Mancuso Francesca , Giustarini Daniela , Bellucci Catia , Vacca Carmine , Aglietti Maria Chiara , Stabile Anna Maria , Rossi Ranieri , Cruciani Gabriele , Rende Mario , Calafiore Riccardo , Luca Giovanni , Galli Francesco 
Published: May 2022

AbstractMelatonin (MLT) is a cytoprotective agent holding potential to prevent cadmium (Cd) toxicity and its impact in testicular function and fertility. In this study, we explored such potential in porcine pre‐pubertal Sertoli cells (SCs). Cd toxicity resulted in impaired SC viability and function, abnormal cellular H2O2 generation and efflux, and induction of reductive stress by the upregulation of Nrf2 expression and activity, cystine uptake and glutathione biosynthesis, glutathione‐S‐transferase P (GSTP) expression, and protein glutathionylation inhibition. Cd toxicity also stimulated the activity of cellular kinases (MAPK‐ERK1/2 and Akt) and NFkB transcription factor, and cJun expression was increased. MLT produced a potent cytoprotective effect when co‐administered with Cd to SCs; its efficacy and the molecular mechanism behind its cytoprotective function varied according to Cd concentrations. However, a significant restoration of cell viability and function, and of H2O2 levels, was observed both at 5 and 10 μM Cd. Mechanistically, these effects of MLT were associated with a significant reduction of the Cd‐induced activation of Nrf2 and GSTP expression at all Cd concentrations. CAT and MAPK‐ERK1/2 activity upregulation was associated with these effects at 5 μM Cd, whereas glutathione biosynthesis and efflux were involved at 10 μM Cd together with an increased expression of the cystine transporter xCT, of cJun and Akt and NFkB activity. MLT protects SCs from Cd toxicity reducing its H2O2 generation and reductive stress effects. A reduced activity of Nrf2 and the modulation of other molecular players of MLT signaling, provide a mechanistic rational for the cytoprotective effect of this molecule in SCs.