bluuebunny/crossref_metadata_2025_split huggingface dataset:
Illustration of a Methodology to Characterize Some Preference Uncertainties in Multicriteria Decision Analysis
Authors: Thiessen Ron J. , Achari Gopal 
Published: September 2022

Abstract
Any multicriteria decision analysis (MCDA) method should make sense to its users and be practical in helping make decisions. Using selected civil and environmental engineering examples in life cycle sustainability assessment and in prioritizing environmental assessment and remediation, the presented methodology strives to meet this objective by emphasizing the importance of visualizing some of the preference uncertainties associated with choice and ranking decision analyses. The emphasis on visualization should compel stakeholders to discuss MCDA results and deliberate conclusions, which is a need in any MCDA practice. The methodology employs simple yet well-founded equations derived from partial-order theory for uncertainty visualization. These equations can be easily programmed using a spreadsheet software or used via a publicly available software highlighted in the article. In addition to its simplicity, the methodology avoids the requirement to quantify stakeholder preferences or to aggregate attribute scores in all situations. As shown through the examples, reasonable decisions can often be made by visualizing the information as it is.
Reducing Impact of Wind on Tall Buildings Through Aero-dynamic Shape Modifications
Authors: GHOTE TILAKCHAND , Wankhade L R 
Published: September 2022

AbstractInstead than being driven by aerodynamic concerns, new generations of tall structures are becoming taller, more flexible, and slimmer due to architectural factors, functional requirements, and site constraints. Tall buildings are hence more vulnerable to lateral loads like wind. Aerodynamic form adjustment can considerably lessen these effects. In terms of fluid dynamics, drag force describes how a solid object behaves in the direction of the relative wind flow velocity. This investigation involves drag coefficient of aerodynamically shape modified buildings with combinations such as setback with void(S + V), corner cut with void(CC + V), setback with corner cut(S + CC) comparatively with square, setback and corner cut. The model is generated using SOLIDWORKS software and further analyse in the ANSYS FLUENT 19.2.) The velocity and pressure contours for these model has been studied along with drag and lift coefficient.
Knowledge, Attitudes, and Practices Regarding Antibiotic Use and Resistance among Health Science and Non-Health Science University Students in Thailand
Authors: Precha Nopadol , Sukmai Suphachai , Hengbaru Muhammadsarif , Chekoh Muhammadkaddfee , Laohaprapanon Sawanya , Makkaew Prasert , Dom Nazri Che 
Published: September 2022

Abstract
Background
Antibiotic-resistant bacteria (ARB) have been recognized as one of the global health issues affecting humans, animals, and the environment. A lack of knowledge, negative attitudes, and irrational drug use can make significant contributions to the spread of ARB. This study aimed to assess the knowledge, attitudes, and practices (KAP) regarding antibiotic use and resistance among health science (HS) and non-health science (NHS) students and to determine the factors that influence their KAP concerning antibiotic use and resistance.
Methods
A cross-sectional study was conducted among 404 HS and NHS students in Southern Thailand from December 2021 to March 2022. The students who fulfilled the study inclusion criteria responded to a questionnaire that had five dimensions. Descriptive statistics were used to analyze the qualitative variables, and Fisher’s exact test was applied to compare the demographic variables between the HS and NHS students. Chi-squared tests were used to compare the percentages of each KAP question between the HS and NHS students. The KAP regarding antibiotic use and resistance for each variable were compared using the Mann–Whitney U test and Kruskal–Wallis H test. Spearman’s correlation test was used to estimate the correlation between the variables and KAP.
Results
A total of 404 (HS,162; NHS,242) students completed the self-administered questionnaire. The students’ highest score was for attitude, followed by practice and knowledge. Our findings revealed that the HS students had higher levels of KAP correlated with antibiotic use and resistance than the NHS students (P < 0.001). The higher KAP scores were among the more senior students, which indicates that instruction on antibiotics was effective in their curriculum.
Conclusions
Antibiotic use and resistance knowledge and attitudes should be conveyed to all university students via courses, seminars, or workshops. Such interventions could set the standard for rational antibiotic use as well as long-term prevention and control of antibiotic-resistant bacteria.
The factors influencing wildlife to use of existing bridges and culverts in Giant Panda National Park
Authors: Lu Song , Yue Ying , Wang Yihong , Zhang Dawei , Yang Biao , Yu Zhen , Lin Honghui , Dai Qiang 
Published: September 2022

Abstract
Roads, acting as barriers, hamper wildlife movements and disrupt habitat connectivity. Bridges and culverts are common structures on roads, and some of them can function to allow wildlife passage. This study investigated the effects of traffic, surrounding landscape, human disturbance, and bridge and culvert structures on the utilization of bridges and culverts as underpasses by wildlife, using motion-activated infrared camera traps along a 64 km road in Giant Panda National Park, Sichuan, China. The results found that both species richness and counts of wildlife recorded at the bridge and culvert were significantly lower than those observed at the control sites far away from roads. No large-sized wildlife was recorded at the bridges and culverts. Human activities and traffic volume significantly and negatively affected medium-sized wildlife utilization of bridges and culverts. Compared with medium-sized wildlife at control sites, those at bridges and culverts tended to be recorded at night, when traffic was spare. We conclude that functions as wildlife crossing structures served by bridges and culverts were worked but weak. It emphasized the necessity of retrofitting bridges and culverts by mitigation facilities such as noise and light barriers and vegetation restoration on both sides of the roads in Giant Panda National Park.
Laparoscopic-assisted pyloromyotomy for cases of hypertrophic pyloric stenosis, a safer new technique
Authors: Khairi Ahmed , Louka Baher , Kamel Tarek , Elrouby Ahmed 
Published: September 2022

Abstract
Purpose
The main difficulty of laparoscopic pyloromyotomy (LP) is the method of spreading and deepening the incised pyloric mass. The aim of the work was the presentation of the surgical outcome of a new procedure of laparoscopic-assisted pyloromyotomy using a fine curved artery forceps for muscle spreading.
Methods
Our prospective study included 24 pediatric patients with IHPS. Under general anesthesia, the patient was positioned transversely on the operating table and the working instruments were inserted directly without ports through the umbilicus, right hypochondrium, and the epigastrium. The mass was grasped by the right instrument holding the duodenum and the pyloromyotomy knife was inserted through the epigastric incision and incised the pyloric mass transversely. The knife was then removed and a fine curved artery forceps was inserted to complete the pyloromyotomy.
Results
The age of the studied patients was 20–50 days (36.48 ± 8.98 days) and their body weight was 2500–3200 gm (2864 ± 271.11 gm). The operative duration was 15–25 minutes (19.08 ± 3.86 minutes). No intra-operative complications were encountered without any need for conversion to open pyloromyotomy in any case. All of the studied patients started oral feeding on the 1st to 2nd postoperative day and were discharged from the hospital on the same day. One patient had persistent postoperative vomiting, US revealed persistence of the mass, and a redo open pyloromyotomy was done.
Conclusion
The described technique is safe, making the control of pyloromyotomy more secure without the need for special instruments.
Evaluation of Lithium chloride effects as a GSK3-β inhibitor on human Adipose Derived Stem cells differentiation into oligodendrocytes and re-myelination in animal model of multiple sclerosis
Authors: Ghosouri Sahar , Soleimani Mitra , Bakhtiari Mohammad , Ghasemi Nazem 
Published: September 2022

Abstract

The application of neuroprotective agents in combination with stem cells, is considered as a potential effective treatment for Multiple sclerosis (MS). So, the effects of lithium chloride as a neuroprotective agent and a GSK3-β inhibitor was evaluated in combination with human adipose derived stem cells on re-myelination, oligodendrocyte differentiation, as well as functional recovery. After inducing mouse model of MS and proving it through hanging wire test, the mice were randomly assigned to five experimental groups including: Cup, Sham, Li, hADSC, and Li + hADSC groups. In addition, a control group with normal feeding was considered. At the end, toluidine blue staining was done to estimate the level of myelination. Moreover, Immunofluorescent staining was used to evaluate the mean of OLIG2 and MOG positive cells. Also, the mRNA levels of β-Catenin, myelin and oligodendrocyte specific genes were determined via Real Time-PCR. The results of hanging wire test and toluidine blue staining showed a significant increase in myelin density and motor function improvement in groups which received lithium and stem cells, especially in Li + hADSC group compared to untreated groups (P < 0.01). In addition, immunostaining results indicated that the mean percentage of MOG and OLIG2 positive cells were significantly higher in Li + hADSC group in compared to other groups (P < 0.01). Finally, gene expression studies showed that the use of lithium can able to increase the expression of β-Catenin, myelin and oligodendrocyte specific genes. The use of Lithium Chloride can able to increase stem cells differentiation into oligodendrocytes and improve re-myelination in MS.
Early Triassic super-greenhouse climate driven by vegetation collapse
Authors: Xu Zhen , Yu Jianxin , Yin Hongfu , Merdith Andrew , Hilton Jason , Allen Bethany , Wignall Paul , Dunhill Alexander , Gurung Khushboo , Shen Jun , Schwartzman David , Godderis Yves , Donnadieu Yannick , Wang Yuxuan , Zhang Yinggang , Poulton Simon , Mills Benjamin 
Published: September 2022

Abstract
The Permian–Triassic Mass Extinction (PTME), life’s most severe crisis1, has been attributed to intense global warming triggered by CO2 emissions from Large Igneous Province volcanism2–8. It remains unclear, however, why super-greenhouse conditions persisted for around five million years after the volcanic episode, when Earth system feedbacks should have returned temperatures to pre-extinction levels within a few hundred thousand years8. Here we use fossil occurrences and lithological indicators of climate to reconstruct spatio-temporal maps of plant productivity and biomass changes through the Permian–Triassic and undertake climate-biogeochemical modelling to investigate the unusual longevity and intensity of warming. Our reconstructions show that terrestrial vegetation collapse during the PTME, especially in tropical regions, resulted in an Earth system with low levels of organic carbon sequestration and chemical weathering, leading to limited drawdown of greenhouse gases. This led to a protracted period of extremely high surface temperatures, during which biotic recovery was delayed for millions of years. Our results support the idea that thresholds exist in the climate-carbon system beyond which warming may be amplified substantially.
Treatment of severe ankylosing spondylitis with high-dose secukinumab: A retrospective study
Authors: Lei Hongwei , Huang He , Ma chenxi , Li Yingnan 
Published: September 2022

Abstract
Background: Secukinumab is an effective biological agent for the treatment of ankylosing spondylitis(AS); however, some patients do not respond well to the administration of 150 mg every 4 weeks and require more effective management measures. This retrospective study evaluates the efficacy and safety of the administration of secukinumab (300 mg every 4 weeks) in patients with severe AS.
Methods: We reported 12 patients with severe ASand retrospectively reviewed their clinical records and follow-up data. These 12 patients were predominantly men (83.33%)with a mean age of 39.33 ± 13.01 years at the start of secukinumab treatment. Their mean body mass index was 27.48 ± 1.21kg/m2. The patients showed severe disease activity at baseline [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score > 4]. The protocol of administration of subcutaneous loading doses of secukinumab every 5 weeks was instituted, followed by subcutaneous administration of secukinumab, 300 mg every 4 weeks or 150 mg every 3 weeks; the patients were advised against off-label use. The assessment of the patients’ conditions, including the Ankylosing Spondylitis Disease Activity Score (ASDAS), BASDAI, and Bath Ankylosing Spondylitis Functional Index (BASFI) was performed at weeks 12 and 24.
Results: All 12 patients had a reduction of more than 1.1 in the ASDAS at week 12, and the effect persisted through to week 22. The 50% BASDAIresponse rate was 58.3% at week 12 and 83.3% at week 24. No new safety findings were observed.
Conclusion: Subcutaneous administration of secukinumab, 300 mg every 4 weeks or 150 mg every 3 weeks, showed sustained efficacy of AS and a consistent safety profile after 24 weeks of treatment. This study is a retrospective study with a limited number of cases and a short observation period, which were the major limitations of the study. This retrospective study provides powerful evidence for the novel treatment strategy of refractory active AS switching to 300 mg secukinumab.
Factors Influencing Hemodialysis Patients Survival Using Frailty Models
Authors: Montaseri Maryam , Dindarloo Mohammad Mehdi , Espahbodi Fatemeh , Yazdani-Charati Jamshid 
Published: September 2022

Abstract
Background and objection:
Hemodialysis is the most common renal replacement therapy in patients with End Stage Renal Disease (ESRD). This study investigated the 5-year survival rate of hemodialysis patients admitted to Imam Khomeini and Fatima Zahra Hospitals in Sari.
Materials & Methods
This study was performed on 335 patients on hemodialysis referring to Imam Khomeini and Fatima Zahra Hospitals from November 2008 to November 2013. To investigate the factors influencing the patients' survival rate, we used Cox model and Frailty model and compared these models efficiency, we also applied the Akaikie information criterion and the residuals review. All calculations have been performed with SPSS version 20 & STATA version 8 and the significance level was 0.05.
Findings:
The results of this study showed that applying the Kaplan– Meier method to determine one, three and five year’s survival rates for hemodialysis patients were 74.9%, 53.2% and 20.4%, respectively. The mean survival time was 37.241 months. In the final model, in multivariate analysis of the gamma frailty model, the variables as age, education, marital status, diabetes, Kidney stone & obstructions, the clinic, the mean serum albumin and urea have been identified as the most important predictors in hemodialysis patients' survival (p < 0.05).
Conclusion
According to the results of the frailty model fitness, the hemodialysis patients having the same explanatory variables also have different risk of death. Giving the Akaikie information criterion and the residuals review, the Weibull model with gamma frailty is more efficient than the Cox model and it has good fitness to the data.
Choice of Anesthesia Regimen Significantly Impacts Shunting and Diastolic Ventricular Function During Cardiac Catheterization
Authors: Healan SJ , Staudt GE , Nicholson GT , Janssen  , Doyle TP , Smith HA , McEachern WA , Hill NE , Lamb FS 
Published: September 2022

Abstract
Background
Most pediatric cardiac catheterizations are performed under general anesthesia, but few studies have examined how choice of anesthesia agent impacts hemodynamic data in pediatric patients. Our objective was to compare hemodynamics obtained under inhaled versus total intravenous anesthesia, and to determine if one more closely reflects the awake state.
Methods
Pediatric patients requiring percutaneous closure of a patent ductus arteriosus (PDA) or surveillance endomyocardial biopsy after orthotopic heart transplant (OHT) at Monroe Carell Jr. Children’s Hospital at Vanderbilt were enrolled. Each participant underwent hemodynamic assessment under inhaled volatile anesthesia (sevoflurane), and then under total intravenous anesthesia (dexmedetomidine and propofol) after a brief washout period. Paired data were analyzed using the Wilcoxon-signed rank test. Linear regression was used to analyze correlation between continuous variables.
Results
Twenty-five patients (13 OHT, 12 PDA) aged 6 months to 18 years were studied. Compared to baseline pre-procedure non-invasive blood pressure, systolic blood pressure was significantly lower under inhaled anesthesia versus intravenous anesthesia. Systemic vascular resistance was also significantly lower under inhaled anesthesia, while pulmonary vascular resistance was similar in both phases. In patients with a PDA, left-to-right shunting increased significantly under intravenous anesthesia versus inhaled. Similarly, in transplant patients, left ventricular end diastolic pressure (LVEDP) increased following transition to intravenous anesthesia, with a positive correlation between the increase observed and the initial LVEDP under inhaled anesthesia.
Conclusions
Hemodynamics were impacted by the mechanism of general anesthesia. An intravenous anesthesia regimen may more closely reflect the awake, pre-catheterization state compared to inhaled volatile anesthesia.
Incidence and risk factors of bowel dysfunction after minimally invasive rectal cancer surgery
Authors: Ota Emi , Nagasaki Toshiya , Akiyoshi Takashi , Mukai Toshiki , Hiyoshi Yukiharu , Yamaguchi Tomohiro , Fukunaga Yosuke 
Published: September 2022

Abstract
Purpose
Bowel dysfunction after sphincter-preserving-surgery (SPS) has a negative impact on the quality of life. Wexner and low anterior resection syndrome (LARS) scores are well-established instruments for assessing postoperative bowel dysfunction. This study aimed to analyze each symptom’s incidence and risk factors based on these scores. Additionally, the discrepancies between the two scores were analyzed.
Methods
Between May 2018 and July 2019, 142 patients with rectal cancer who underwent SPS via a minimally invasive surgery were included in this study. A questionnaire survey using the Wexner and LARS scores was administered 2-year after SPS or diverting ileostomy closure.
Results
Preoperative radiotherapy (RT) was a risk factor for five subscales composing the Wexner and LARS scores. Approximately 80% of patients undergoing preoperative RT reported their life-style alterations because of bowel dysfunction. Handsewn coloanal anastomosis (HSA) was a risk factor for the three subscales of the two scores. More than 90% of the patients who underwent HSA experienced urgency and all patients suffered from clustering. Of 35 patients with minor LARS, only one had a high Wexner score, and 28 (80.0%) patients did not report lifestyle alterations. Among the patients with major LARS, 58.7% had a low Wexner score, and 21.3% never felt their lifestyle alterations.
Conclusion
The results of this study provide practical data to facilitate patients’ perception of potential bowel dysfunction after surgery. The discrepancies between the Wexner and LARS scores were clarified, and further efforts are required to utilize these scores in clinical practice.
Knowledge, Attitude, Beliefs and Perception of Periodic Health Checkup Among the General Public Across Dehradun, Uttarakhand
Authors: Dixit Divyansh , Taneja Varun , B Swarna Priya , Kandhuri Tharun 
Published: September 2022

Abstract
Periodic health checkup (PHC) has been recognized as a key instrument in the practice of preventive healthcare since the early 1900s and has been supported for maintaining health and preventing diseases, however, it has never been shown to be economical. Periodic Health Checkups (PHC), a primary level of care provided by healthcare facilities to prevent and manage several chronic diseases, PHCs comprise history-taking, clinical examination, and laboratory investigations in which even asymptomatic people of any age can participate. Disease outcomes and activities connected to health are correlated with socioeconomic level, Low socioeconomic level people are more susceptible to harmful living conditions, obesity, cancer, cardiovascular disease, and other health problems, all of which have a detrimental impact on their quality of life. Moreover, because to their limited exposure to hospitals for basic healthcare services, socioeconomic inequality makes it difficult for such people to benefit from periodic health check-up programs. Low socioeconomic status people have been found to be less likely to participate in Periodic health examinations. Socioeconomic/demographic characteristics also include factors like social class, employment status, educational attainment, and the number of independent years of study. Having health insurance can increase these individuals' likelihood of taking part in the periodic health checkups, here we hope to analyze and evaluate public knowledge, attitudes, and perceptions related various socioeconomic conditions and periodic health checkups through this research study.
Eddystone-UID Frame with Data Confidentiality and Integrity for Secured Data Broadcasting by BLE Beacons
Authors: Gulhane Vijay S. , Padiya Sagar D. 
Published: September 2022

Abstract
Beacons are small-sized embedded devices that periodically broadcasts radio frequency (RF) signals without establishing a connection so that any other Bluetooth-equipped device/s in the range can receive the broadcasted data, but some applications desired that data should be observed only by an authenticated receiver. The beacon specification does not have any authentication mechanism, anyone can observe broadcasted information. Beacon has very limited security provisions, as any observer can receive the signal and also easily get the message. This research defined an extension of Google Eddystone-UID for secured data broadcasting without affecting regular operations. The proposed “Extended Eddystone-UID Frame” assures secured broadcasting by performing the data cryptography and data integrity. The experiment concluded that the proposed frame does not add any extra bytes, therefore, it does not require any more time and energy, and it is capable to broadcast data securely at the same time and energy as standard protocol required.