bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Moderates Family History of Alcohol Use Disorder and Childhood Maltreatment Effects on an fMRI Stop-Signal Task
Authors: Elton Amanda , Allen J. Hunter , Yorke Mya , Khan Farhan , Xu Peng , Boettiger Charlotte A. 
Published: November 2022

ABSTRACTBackgroundChildhood maltreatment (CM) and a family history (FH) of alcohol use disorder (AUD) are each associated with increased impulsivity. However, their unique or shared brain targets remain unknown. Furthermore, both CM and FH demonstrate sex-dependent effects on brain and behavior. We hypothesized that CM and FH interact in brain regions involved in impulsivity with sex-dependent effects.Methods144 first-year college students (18-19 years old) with varying experiences of CM and/or FH but without current AUD performed an fMRI stop-signal task. We tested interactions between FH, CM, and sex on task performance and blood oxygen level-dependent (BOLD) signal during successful inhibitions. We examined correlations between BOLD response and psychiatric symptoms.ResultsSignificant three-way interactions of FH, CM, and sex were detected for brain and behavioral data, largely driven by male subjects. In males, CM was associated with poorer response inhibition but only for those with less FH; males with higher levels of both CM and FH demonstrated better response inhibition. Three-way interaction effects on voxel-wise BOLD response during response inhibition were found in bilateral middle frontal gyrus, left inferior frontal gyrus, dorsomedial prefrontal cortex, and posterior cingulate cortex. Network-level analyses implicated the left frontoparietal network, executive control network, and default-mode network. Greater BOLD response in these networks correlated with lower depressive, impulsive, and attentional symptoms, reduced alcohol misuse, greater resilience scores, and heightened trait anxiety.ConclusionsThe results highlight sex-divergent effects of heritable and environmental risk factors that may account for sex-dependent expression of psychopathology in response to risk factors.
Antibodies to Hepatitis B core antigen prevalence study in Kazakhstan
Authors: Savchuk Tatyana , Grinvald Yelena , Ali Mohamed , Sepetiene Ramune , Saussakova Saniya , Zhangazieva Kuralay , Imashpayev Dulat , Abdrakhmanova Saniya 
Published: November 2022

ABSTRACTBackgroundKazakhstan is being considered as one of the countries that is medium-endemic for Hepatitis B virus infection. This cross-sectional study aimed to evaluate the prevalence of anti-HBcore and the risk factors impacting positive anti-HBcore markers among donors at Scientific-Production Center of Transfusiology, of the Kazakhstan Republic.Study Design and MethodsThe samples taken from blood donors were tested for anti-HBcore, by CLIA on the Architect i2000SR (ABBOTT). In case of positive anti-HBcore, the blood samples were further tested for anti-HBs by CLIA on the Architect i2000SR (ABBOTT). Statistical analysis was conducted by the R software (version 4.1.1, USA, 2021).Results and Discussion5709 people aged 18 to 66 years included in the study, the proportion of men and women was 68.17% and 31.83%. The average age of the participants was 35.7±10.57 years.The prevalence of anti-HBcore among donors was 17.2% (983). Among participants with elevated ALT (170) this marker was determined in 23%, and in donors with normal levels of ALT (5539) - 17%. Participants with positive anti-HBcore scores were on average older (41.8 vs 34.4 years, p<0.001) and Kazakh (88.7% vs 83.0%, p<0.001) by Nationality than study participants with negative results respectively. Anti-HBcore (Antibodies to Hepatitis B core antigen) prevalence in Kazakhstan (17.2%) compared to other countries (8% and more) remains above average. Given the prevalence of HBV and risk factors, it is recommended to include an additional anti-HBcore marker in the mandatory screening of donated blood in the country and improve preventive measures to HBV transmission.
Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lung
Authors: Miura Akihiro , Sarmah Hemanta , Tanaka Junichi , Hwang Youngmin , Sawada Anri , Shimamura Yuko , Fang Yinshan , Shimizu Dai , Ninish Zurab , Suer Jake Le , Dubois Nicole C. , Davis Jennifer , Toyooka Shinichi , Wu Jun , Que Jianwen , Hawkins Finn J. , Lin Chyuan-Sheng , Mori Munemasa 
Published: November 2022

AbstractMillions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Identifying the crucial lineage and the program for lung organogenesis could facilitate designing whole-lung bioengineering. Using lineage-tracing mice and human iPSC-derived lung-directed differentiation, we revealed that gastrulating Foxa2 lineage contributed to both lung mesenchyme and epithelium formation. Interestingly, Foxa2 lineage-derived cells in the lung mesenchyme progressively increased and occupied more than half of the mesenchyme niche, including endothelial cells, during lung development. Foxa2 promoter-driven, conditional Fgfr2 gene depletion caused the lung agenesis phenotype in mice. Importantly, wild-type donor mouse iPSCs injected into their blastocysts rescued this phenotype by complementing the Fgfr2-defective niche in the lung epithelium and mesenchyme. Donor cell is shown to replace the entire lung epithelial and robust mesenchymal niche during early chimeric lung development, resulting in efficient complementation of the nearly entire lung niche at the late stage of lung development. These results suggest that lung complementation based on the Foxa2 lineage is a unique model for the progressive mobilization of donor cells into both epithelial and mesenchymal lung niches and provides crucial insights for designing new bioengineering strategies to generate whole lungs.
Prevalence, causes and impact ofTP53-loss phenocopying events in human tumors
Authors: Fito-Lopez Bruno , Salvadores Marina , Alvarez Miguel-Martin , Supek Fran 
Published: November 2022

AbstractTP53is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity -- which may occur from trans-acting alterations -- from gene expression patterns. We apply this approach to transcriptomes of ~8,000 tumors and ~1,000 cell lines, estimating that 12% and 8% of tumors and cancer cell lines phenocopyTP53loss: they are likely deficient in the activity of the p53 pathway, while not bearing obviousTP53inactivating mutations. While some of these are explained by amplifications in the known phenocopying genesMDM2, MDM4andPPM1D, others are not. An analysis of cancer genomic scores jointly with CRISPR/RNAi genetic screening data identified an additionalTP53-loss phenocopying gene,USP28. Deletions inUSP28are associated with aTP53functional impairment in 2.9-7.6% of breast, bladder, lung, liver and stomach tumors, and are comparable toMDM4amplifications in terms of effect size. Additionally, in the known CNA segments harboringMDM2, we identify an additional co-amplified gene (CNOT2) that may cooperatively boost theTP53functional inactivation effect. An analysis using the phenocopy scores suggests thatTP53(in)activity commonly modulates associations between anticancer drug effects and relevant genetic markers, such asPIK3CAandPTENmutations, and should thus be considered as a relevant interacting factor in personalized medicine studies. As a resource, we provide the drug-marker associations that differ depending onTP53functional status.
Examining the Reproductive Success of Bull Kelp (Nereocystis luetkeana) in Climate Change Conditions
Authors: Korabik Angela R. , Winquist Tallulah , Grosholz Edwin D. , Hollarsmith Jordan A. 
Published: November 2022

AbstractClimate change is affecting marine ecosystems in many ways including rising temperatures and ocean acidification. From 2014-2016, an extensive marine heatwave extended along the west coast of North America and had devastating effects on numerous species during this period, including bull kelp (Nereocystis luetkeana). Bull kelp is an important foundation species in coastal ecosystems that can be affected by marine heat waves and ocean acidification, however these impacts have not been investigated on sensitive early life stages. To determine the effects of changing temperatures and carbonate levels on Northern California’s bull kelp populations, we collected sporophylls from mature bull kelp individuals in Point Arena, CA. At the Bodega Marine Laboratory, we released spores from field-collected bull kelp, and cultured microscopic gametophytes in a common garden experiment with a fully factorial design crossing modern conditions (11.63±0.54°C and pH 7.93±0.26) with observed extreme climate conditions (15.56±0.83°C and 7.64±0.32pH). Our results found that both increased temperature and decreased pH influenced growth and egg production of bull kelp microscopic stages. Increased temperature generally resulted in decreased gametophyte survival and offspring production. In contrast, decreased pH had less of an effect, but generally resulted in increased gametophyte survival and offspring production. Additionally, we found that increased temperature significantly impacted reproductive timing by causing female gametophytes to produce offspring earlier than under ambient temperature conditions. Our findings inform better predictions of the impacts of climate change on coastal ecosystems as well as provide key insight into environmental dynamics regulating the bull kelp lifecycle.
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children
Authors: Shen Chun , Rolls Edmund T. , Xiang Shitong , Langley Christelle , Sahakian Barbara J. , Cheng Wei , Feng Jianfeng 
Published: November 2022

AbstractClose friendships are important for mental health and cognition in late childhood. However, whether the more close friends the better, and the underlying neurobiological mechanisms are unknown. Using the Adolescent Brain Cognitive Developmental study, we identified nonlinear associations between the number of close friends, mental health, cognition, and brain structure. Although few close friends were associated with poor mental health, low cognitive functions and small areas of the social brain (e.g., the orbitofrontal cortex, the anterior cingulate cortex, the anterior insula and the temporo-parietal junction), increasing the number of close friends beyond a level (around 5) was no longer associated with better mental health and larger cortical areas, and was even related to lower cognition. In children having no more than 5 close friends, the cortical areas related to the number of close friends revealed correlations with the density of μ-opioid receptors and the expression of OPRM1 and OPRK1, and could partly mediate the association between the number of close friends, ADHD symptoms, and crystalized intelligence. Longitudinal analyses showed that both too few and too many close friends at baseline were associated with more ADHD symptoms and lower crystalized intelligence 2 years later. Additionally, we found friendship network size was nonlinearly associated with well-being and academic performance in an independent social network dataset of middle school students. These findings challenge the traditional idea of “the more, the better”, and provide insights into potential brain and molecular mechanisms.
Framing the tourist spatial identity of a city as a tourist product
Authors: Rozman Cafuta Melita 
Published: November 2022

Purpose
The purpose of this paper is to develop a methodology for shaping the tourist spatial identity of the city and to take advantage of it to discover alternative urban outdoor spaces. As the number of indoor visitors has been limited due to the COVID-19 pandemic, open urban areas such as streets, squares and parks have become more important tourist locations.

Design/methodology/approach
The assessment methodology consists of two basic steps. In the first step, the authors look for places or points that are carriers of spatial identity. For this purpose, the method of mental mapping is used. In the second step, statistical methods are used to evaluate the spatial suitability for the most common tourist activities. To obtain a holistic picture, a temporal component is included.

Findings
The application of the methodology is presented in the form of a case study. The obtained research results provide an insight into the spatial situation of the city of Maribor (Slovenia, Europe). Tourist spatial identity of a city depends on time. Based on the value of spatial sensitivity indicator and the suitability of activities, it is possible to adapt the tourist offer to the temporal component.

Originality/value
To the best of the authors’ knowledge, this is an original perspective on the spatial identity of tourists. The presented approach could be integrated as a good practice in any other city worldwide. It supports the identification of suitable outdoor tourist places that are memorable, cosy, multifunctional and can be recommended by city guides (mobile or printed books). Every city has many hidden gems that tourists have yet to discover.
Factors that hinder the thesis writing process of non-native MA students in ELT: supervisors' perspectives
Authors: Khozaei Ravari Zahra , Ul Islam Qamar , Khozaei Fatemeh , Choupan Zarvijani Sara Betlem 
Published: November 2022

PurposeDeveloping graduate students' academic writing has been a major concern for many scholars over the past few years. Existing literature on the challenges of thesis writing has not focused on master's students in English language teaching (ELT). Data on the challenges have been mainly gathered from the theses and focused on the structure and genre requirements. Few available studies have investigated such challenges through the lens of supervisors in an international context. Knowledge about the factors hindering the thesis writing process of non-native MA students in English from the supervisors' perspectives is scarce. This study attempts to fill these gaps by answering this question: From supervisors' perspectives, what factors hinder the thesis writing process of non-native MA students?Design/methodology/approachThirty supervisors from state and private universities across Iran voluntarily participated in this qualitative study. Drawing upon teachers' diaries and semi-structured interviews, the authors identified major factors negatively influencing the thesis work of master's students. Data were transferred into NVivo 10 and analyzed thematically following Colaizzi's method.FindingsThe study found that factors constraining students' writing were (1) students' lack of effort, (2) students' lack of a strategy for writing, (3) students' lack of autonomy and (4) students' absence of voice.Originality/valueThe authors discuss the practical implications of these factors for different stakeholders. There is a growing interest in postgraduate students' thesis writing processes. Surprisingly, no research exists on supervisors' perceptions of factors that constrain the thesis writing process of non-native English master's students.
Suspicious places make people suspicious: Officers’ perceptions of place‐based conditions in racialized drug enforcement
Authors: Gaston Shytierra , Brunson Rod K. , Ayeni David O. 
Published: November 2022

AbstractResearch SummaryPlace‐based conditions are well‐established predictors of police behavior, but the literature lacks nuanced examinations of how place‐based factors influence officer decision making, especially by citizen race/ethnicity and from officers’ perspectives. We investigate officers’ accounts regarding how they weigh place‐based factors into their arrest decisions of Black, Hispanic, and White drug suspects in Newark, New Jersey from 2011 to 2016. Our analysis of 438 filed drug arrest reports revealed that most arrestees, especially Black Americans, became susceptible to heightened police scrutiny because of their presence in stigmatized, criminalized areas. Although place‐based stigma and individualized prohibited behavior coalesced to guide police contacts with Hispanic and White residents, officers made contacts with Black Americans based on a lower legal basis, often irrespective of their individualized behavior in stigmatized places.Policy ImplicationsOfficers’ differential, racialized reliance on place‐based conditions supports the need for effective, evidence‐based, community‐centered social services that reduce crime, overreliance on police, and opportunities for discriminatory policing.
Process‐based calibration of WRF‐Hydro in a mountainous basin in southwestern U.S.
Authors: Mascaro Giuseppe , Hussein Abdinur , Dugger Aubrey , Gochis David J. 
Published: November 2022

AbstractThe National Water Model (NWM) will provide the next generation of operational streamflow forecasts across the United States (U.S.) using the WRF‐Hydro hydrologic model. In this study, we propose a strategy to calibrate 10 parameters of WRF‐Hydro that control runoff generation during floods and snowmelt seasons, and due to baseflow. We focus on the Oak Creek Basin (820 km2), an unregulated mountainous sub‐watershed of the Salt and Verde River Basins in Arizona, which are the largest source of water supply for the Phoenix Metropolitan area. We calibrate the model against discharge observations at the outlet in 2008–2011, and validate it at two stream gauging stations in 2012–2016. After bias correcting the precipitation forcings, we sequentially modify the model parameters controlling distinct runoff generation processes in the basin. We find that capturing the deep drainage to the aquifer is crucial to improve the simulation of all processes and that this flux is mainly controlled by the SLOPE parameter. Performance metrics indicate that snowmelt, baseflow, and floods due to winter storms are simulated fairly well, while flood peaks caused by summer thunderstorms are severely underestimated. We suggest the use of spatially variable soil depth to enhance the simulation of these processes. This work supports the ongoing calibration effort of the NWM by testing WRF‐Hydro in a watershed with a large variety of runoff mechanisms that are representative of several basins in the southwestern U.S.
Building Trust with Material and Immaterial Corporate Social Responsibility: Benefits and Consequences*
Authors: Hoang Hien , Phang Soon‐Yeow 
Published: November 2022

ABSTRACTWe examine whether the benefits and consequences of building trust through corporate social responsibility (CSR) vary when the company engages in material or immaterial CSR, and the conditions under which these benefits hold. Our study informs companies about the relative benefits and consequences of engaging in particular types of CSR activities. Prior archival research finds that CSR performance can buffer companies against negative stock reactions caused by subsequent adverse events, such as financial restatements. However, theory suggests that there are boundary conditions for this buffering effect through the multiple dimensions of trust violations. We predict and find using Experiment 1 that positive performance in material CSR enhances competence trust, while positive performance in immaterial CSR enhances integrity trust in the company. We predict and find using Experiment 2 that positive material CSR performance alleviates investors' negative reactions to an error restatement but that this effect does not occur for a fraud restatement. In contrast, positive immaterial CSR performance results in greater negative reactions to a fraud restatement, but this effect does not occur for an error restatement. These effects can be explained through the multiple dimensions of trust and trust violation, in accordance with the schematic model of dispositional attribution. Lastly, a supplementary experiment supports the robustness of our results to the baseline of neutral CSR performance. Our study has important implications for companies and standard setters about the trust‐building effects of engagement in CSR and, more generally, of how CSR issues with different materiality levels buffer against the adverse effects of negative events.
Management of atrial flutter and atrial fibrillation with rapid ventricular response in patients with acute decompensated heart failure: A systematic review
Authors: Niforatos Joshua D. , Ehmann Michael R. , Balhara Kamna S. , Hinson Jeremiah S. , Ramcharran Lukas , Lobner Katie , Weygandt P. Logan 
Published: November 2022

AbstractObjectiveThe objective was to evaluate the comparative effectiveness and safety of pharmacological and nonpharmacological management options for atrial fibrillation/atrial flutter with rapid ventricular response (AFRVR) in patients with acute decompensated heart failure (ADHF) in the acute care setting.MethodsThis study was a systematic review of observational studies or randomized clinical trials (RCT) of adult patients with AFRVR and concomitant ADHF in the emergency department (ED), intensive care unit, or step‐down unit. The primary effectiveness outcome was successful rate or rhythm control. Safety outcomes were adverse events, such as symptomatic hypotension and venous thromboembolism.ResultsA total of 6577 unique articles were identified. Five studies met inclusion criteria: one RCT in the inpatient setting and four retrospective studies, two in the ED and the other three in the inpatient setting. In the RCT of diltiazem versus placebo, 22 patients (100%) in the treatment group had a therapeutic response compared to 0/15 (0%) in the placebo group, with no significant safety differences between the two groups. For three of the observational studies, data were limited. One observation study showed no difference between metoprolol and diltiazem for successful rate control, but worsening heart failure symptoms occurred more frequently in those receiving diltiazem compared to metoprolol (19 patients [33%] vs. 10 patients [15%], p = 0.019). A single study included electrical cardioversion (one patient exposed with failure to convert to sinus rhythm) as nonpharmacological management. The overall risk of bias for included studies ranged from serious to critical. Missing data and heterogeneity of definitions for effectiveness and safety outcomes precluded the combination of results for quantitative meta‐analysis.ConclusionsHigh‐level evidence to inform clinical decision making regarding effective and safe management of AFRVR in patients with ADHF in the acute care setting is lacking.