bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between ocular biometric measurements and pediatric migraine
Authors: ŞİMDİVAR Göksu Hande Naz , SARIGEÇİLİ Esra , İNCEKALAN Tuğba , KOÇ UÇAR Habibe 
Published: June 2022

Purpose: The aim of this study was to evaluate biometry parameters and anterior segment parameters in pediatric migraine patients compared to controls.
Materials and Methods: This prospective case-control study included 40 patients and 45 controls. All participants underwent a complete ophthalmological examination followed by measurement of anterior chamber depth (ACD), vitreous chamber depth (VCD), lens thickness (LT), axial length (AL), central corneal thickness (CCT), corneal volume (CV), anterior chamber volume (ACV), iridocorneal angle (ICA), pupil diameter (PD) and mean keratometry (Km). Pupil diameter was compared between patients with and without photophobia. All evaluations were made in attack-free period. Pupil diameter was compared in migraine patients with and without photophobia. Intraocular pressure and biometery measurements were taken at the same time of day (10:00–12:00) in order to minimize the effects of diurnal variation. Right eye measurements were included in the study.
Results: The two groups showed no statistical differences in ACD, VCD, LT, AL, CCT, CV, ACV, ICA, PD, IOP, spherical equivalent or Km. There was no difference in PD between patients with and without photophobia .
Conclusion: Pediatric migraine patients do not differ from controls in terms of biometry, corneal topography, or keratometry parameters. Studies with larger patient populations are needed to determine the relationship between ocular biometric parameters and migraine.
Effect of COVID-19 social isolation on the fear of COVID-19, quality of life and cognitive functions in the elderly
Authors: YILDIRIM Duygu İlke , AY Enes , ERYILMAZ Mehmet , GÜRER Nursena , ÇAKIRELİ Salih Zeki , KETEN Hatice Betül , KOÇ Mehmet 
Published: June 2022

Purpose: The purpose of this study is to appraise the impact of COVID-19 social isolation on fear of COVID-19, quality of life and cognitive functions.
Materials and Methods: Individuals aged 65 and over who made an appointment for the CoronaVac vaccine via appointment system and 603 people residing in these houses, wanted to be vaccinated, gave informed consent for the vaccine and agreed to participate, were included in the study. Sociodemographic data form, Coronavirus 19 Phobia Scale, Mini Mental State Test and Short Form 36 Quality of Life Scale were filled in by the study population.
Results: Patients included in our research, 63.0% were female (n=380) and 37.0% were male (n=223). The mean age was 77.65 ± 8.05 (min:65, max:97) years. Status of having a relative with COVID-19, social function status of SF-36, mental health status of SF-36 economic status of CP19-S size and the total score of CP19-S were found as multivariate predictors of COVID-19 disease transmission. As the total score of the participants from the COVID-19 phobia scale increased, their cognitive functions significantly decreased.
Conclusion: These findings reported important results regarding the effects of social isolation experienced by the elderly during the COVID-19 pandemic on quality of life, cognitive functions, and COVID-19 fear levels.
Harmony of the foramen magnum and cranium: An anatomical and radiological study
Authors: OKSÜZLER Mahmut , VURALLI Duygu , ÖZANDAÇ POLAT Sema , GÖKER Pınar 
Published: June 2022

Purpose: The measurements’ reference points associated with foramen magnum (FM) and cranium were examined in this retrospective study. Also, the relation between FM and cranium harmony were calculated both on dry skull and in healthy subjects performed on computed tomography (CT).
Materials and Methods: The present study was carried out on 185 healthy adult subjects (90 females; 95 males) aged between 18–67 years and 15 dried skull of unknown gender of an Anatolian population. The shapes of the FM were classified as two semicircle, oval, round, egg, tetragonal, pentagonal, hexagonal and irregular shapes. The anteroposterior length and transverse width of the FM and cranium were measured on both photos and CT.
Results: The means and standard deviations of the measurements were given for three groups. To control the accuracy of FM width (FMW) and length (FML) results, a formula was used for three groups including dried skull and CT measurements of females and males, seperately (FMW=Cranial width (CW)/4.26 for group 1, CW/4.66 for group 2 and CW/4.66 for group 3; and FML=Cranial length (CL)/4.51 for group 1, CL/4.33 for group 2 and CL/4.16 for group 3). The oval type FM was predominant (26.67%) in dried skull and (23.33%) in females and (28.42%) in males.
Conclusion: The present study presents noteworthy data about FM and cranium harmony of the adult Turkish population and dry skulls that will show a harmony between cranium and foramen magnum in clinical practice. There was no tetragonal and hexagonal FM types in dried skulls and tetragonal type FM was the least seen type in females and males.
TWO-YEAR MORTALITY PROFILE IN ELDERLY WITH FRAILTY : Observational Descriptive Study in Elderly Health Community in Surabaya, Indonesia
Authors: Faizah Ummi Ziyadatul , Widajanti Novira , Ichwani Jusri 
Published: June 2022

Indonesia in the next few years will face problems related to the increasing population of the elderly. Frailty becomes one of the most common health problems in the elderly. The prevalence of frailty in the Indonesian elderly range from 17% to 36.5%. Frailty raises the risk of death and health care costs, as well as functional disability, hospitalization, and fall risk. This was an observational descriptive study conducted in the elderly health community in Surabaya. This study aimed to determine the proportion and describe the associated factors of 2-year mortality in the elderly with frailty, so it can help determine appropriate preventive and intervention ways to prevent mortality and increase the quality of life in the elderly. There were 113 subjects. Most of the subjects had elementary school grade, married, had an income of less than 1.5 million rupiah/month, financially dependent, regularly exercised, did not use walking aids, and had no history of falls in the last year. The mortality rate within 2 years was 8.8% with the characteristics of older than 70 years old, had sarcopenia, decreased functional status, were at risk of malnutrition, CIRS score > 5, moderate cognitive impairment, probably depression, and had components of exhaustion, slowness, and low physical activity based on the CHS Frailty
Latrines Problem, Defecation Behavior, and Implementation of GERBANG JASA in Murtajih Village, Pamekasan, Indonesia
Authors: Susianto Steven Christian , Israna Israna , Haque Izaratul , Habibie Melyana , Ginting Sri Mentari Br , Anggraini Jeni Novita 
Published: June 2022

Unhealthy latrines and defecation behaviors are associated with a higher diarrhea and stunting incidence. The authors developed Healthy Latrine Building Program (GERAKAN BANGUN JAMBAN SEHAT), which is was abbreviated as Gerbang Jasa, to improve latrine problems and long-term effort to prevent stunting. This study aimed to describe the latrine problems and implementation of Gerbang Jasa in Murtajih Village, Pamekasan., Indonesia This research was a descriptive study and involved all families with unhealthy or sharing latrines in Telaga Sari and Pao Gading, Murtajih. We assessed the knowledge and family characteristics through a questionnaire and collected children’s height and age under five years. Thirty families were included in this study, 16 from Pao Gading and 14 from the Telaga Sari. Half of them used unhealthy latrine (cemplung) and the others shared latrines, 59% of farmer occupation and most of them had income under Rp.1.000.000,00. Meanwhile, 12 children under five years from their family was not stunted. During our movement, the authors got funds Rp 18.261.000,00 and successfully built 63,3% latrines with sept tank, 16,7% of latrines only and all the unhealthy latrines were closed by subject. Farmer occupation, family income under Rp 1.000.000,00 were the most cause of latrines problems. Meanwhile, Gerbang jasa could improve latrines problem in Murtajih Village, Pamekasan.
The Role of Amputation and Myoelectric Prosthetic Fitting in Patients with Traumatic Brachial Plexus Injuries
Authors: Cantwell Sean R. , Nelson Andrew W. , Sampson Brandon P. , Spinner Robert J. , Bishop Allen T. , Pulos Nicholas , Shin Alexander Y. 
Published: June 2022

Background:
A cohort of patients with traumatic brachial plexus injuries (BPIs) underwent elective amputation following unsuccessful surgical reconstruction or delayed presentation. The results of amputation with and without a myoelectric prosthesis (MEP) using nonintuitive controls were compared. We sought to determine the benefits of amputation, and whether fitting with an MEP was feasible and functional.

Methods:
We conducted a retrospective review of patients with BPI who underwent elective upper-extremity amputation at a single institution. Medical records were reviewed for demographics, injury and reconstruction details, amputation characteristics, outcomes, and complications. Prosthesis use and MEP function were assessed. The minimum follow-up for clinical outcomes was 12 months.

Results:
Thirty-two patients with BPI and an average follow-up of 53 months underwent elective amputation between June 2000 and June 2020. Among the cases were 18 transhumeral amputations, 12 transradial amputations, and 2 wrist disarticulations. There were 29 pan-plexus injuries, 1 partial C5-sparing pan-plexus injury, 1 lower-trunk with lateral cord injury, and 1 lower-trunk injury. Amputation occurred, on average, at 48.9 months following BPI and 36.5 months following final reconstruction. Ten patients were fitted for an MEP with electromyographic signal control from muscles not normally associated with the intended function (nonintuitive control). Average visual analog scale pain scores decreased post-amputation: from 4.8 pre-amputation to 3.3 for the MEP group and from 5.4 to 4.4 for the non-MEP group. Average scores on the Disabilities of the Arm, Shoulder and Hand questionnaire decreased post-amputation, but not significantly: from 35 to 30 for the MEP group and from 43 to 40 for the non-MEP group. Patients were more likely to be employed following amputation than they were before amputation. No patient expressed regret about undergoing amputation. All patients in the MEP group reported regular use of their prosthesis compared with 29% of patients with a traditional prosthesis. All patients in the MEP group demonstrated functional terminal grasp/release that they considered useful.

Conclusions:
Amputation is an effective treatment for select patients with BPI for whom surgical reconstruction is unsuccessful. Patients who underwent amputation reported decreased mechanical pain, increased employment rates, and a high rate of satisfaction following surgery. In amputees with sufficient nonintuitive electromyographic signals, MEPs allow for terminal grasp/release and are associated with high rates of prosthesis use.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Impact of Orthopaedic Surgeons on National Institutes of Health Funding for Hip and Knee Arthroplasty Research
Authors: Silvestre Jason , Martinez Roxana , Thompson Terry L. , Wilson Robert H. , Nelson Charles L. 
Published: June 2022

Background:The National Institutes of Health (NIH) remains one of the predominant sources of biomedical research funding in the United States, yet its impact on total hip and knee arthroplasty research is poorly understood. This study defines the portfolio of NIH funding for total joint arthroplasty (TJA) and the impact of orthopaedic surgeons on this portfolio.Methods:The Research Portfolio Online Reporting Tools Expenditures and Results (RePORTER) database was queried for NIH grants that had been awarded for total hip and knee arthroplasty and total NIH funding from 2010 to 2020. Compound annual growth rates (CAGRs) were calculated. Funding totals were compared with those from 20 other clinical areas. The principal investigators (PIs) and grants were characterized, and comparisons were made with use of the Student t test.Results:A total of 489 grants were awarded, totaling $181 million (CAGR of 10.3%). This was >3 times the growth rate for the total NIH budget (CAGR of 2.9%), which increased from $31.2 to $41.7 billion over the 11-year period. When compared with 20 other clinical areas, TJA received the least amount of NIH funding over that period. Alzheimer disease received the most funding ($12.1 billion, CAGR of 19.5%), and cerebral palsy received the penultimate amount of funding ($284 million, CAGR of 6.3%). The R01 grant mechanism was the predominant source (63.1%), and the Mayo Clinic (Rochester, Minnesota) received the most funding (9.7%). Departments of orthopaedic surgery were awarded the most funding (23.5%), yet only 20 orthopaedic surgeons were identified as PIs (16.0%). There were no significant differences in NIH funding totals by PI demographic and academic characteristics (p > 0.05), yet orthopaedic surgeons had among the highest Hirsch indices (h-indices) (p < 0.001). Funding supported clinical (63.5%), translational (19.3%), basic science (7.1%), and other types (10.1%) of research. The top areas with funding were postoperative complications (44.4%), postoperative pain management (17.6%), rehabilitation (15.1%), and implant design (12.4%).Conclusions:There is a paucity of orthopaedic surgeon representation among NIH grants awarded for TJA. Opportunities may exist for orthopaedic surgeons to collaborate in identified areas of clinical interest. Additional research is needed to understand the obstacles to obtaining NIH grant funding for orthopaedic surgeon PIs.Clinical Relevance:Increasing the levels of funding from the NIH is a strategic priority for departments of orthopaedic surgery. Understanding levels of funding for clinical areas in total joint arthroplasty is critical to foster research and discovery support from the NIH.
Dekonstruksi dalam Novel Aurora di Langit Alengka Karya Agus Andoko (Kajian Dekonstruksi Derrida)
Authors: Ningrum Arliza Nur Alita , Sutopo Bakti , Widoyoko Riza Dwi Tyas 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui dekonstruksi dalam novel Aurora di Langit Alengka karya Agus Andoko dengan cara mendeskripsikan bentuk-bentuk dekonstruksi dan pemikiran oposisi biner. Penelitian ini merupakan penelitian kualitatif. Pendekatan yang digunakan adalah deskriptif kualitatif. Data dalam penelitian ini adalah kata-kata, kalimat-kalimat, dan dialog-dialog yang terdapat dalam kutipan teks novel Aurora di Langit Alengka karya Agus Andoko.Sumber data dalam penelitian ini adalah novel Aurora diLangitAlengka karya Agus Andoko.Teknik pengumpulan data adalah tekik baca, teknik catat, dan studi pustaka. Keabsahan data menggunakan triangulasi sumber, triangulasi metode, dan triangulasi teori. Analisis data menggunakan pendekatan analisis objektif. Hasil penelitian ini dapat disimpulkan bahwa: 1) bentuk-bentuk dekonstruksi dalam novel Aurora di Langit Alengka karya Agus Andoko meliputi: a) dekonstruksi penculikan Sinta, b) dekonstruksi kematian Subali, c) dekonstruksi kisah Subali dan Sugriwa, d) dekonstruksi kisah Jatayu, e) dekonstruksi kisah Jatayu dan Sampati, f) dekonstruksi kisah Anggada, g) dekonstruksi penyebab perang, h) dekonstruksi akhir kisah Rama dan Sinta. 2) Pemikiran oposisi biner dalam novel Aurora di Langit Alengka meliputi: a) pemikiran oposisi biner tokoh Rama (oposisi biner altruis dan egois), b) pemikiran oposisi biner tokoh Rahwana (oposisi biner pemberani dan penakut), c) pemikiran oposisi biner tokoh Wibisana (oposisi biner pengkhianat dan nasionalis).
Upaya Guru dalam Menyelesaikan Kesulitan Siswa dalam Materi Penjumlahan Bilangan Pecahan Siswa Kelas IV SDN II Sudimoro Kecamatan Sudimoro Tahun Pelajaran 2019/2020
Authors: Argista Niva , Sugiyono Sugiyono , Burhanuddin Afid 
Published: June 2022

Penelitian ini bertujuan: 1) untuk mengidentifikasi kesulitan-kesulitan yang dialami kelas IV SDN II Sudimoro dalam menyelesaikan soal matematika pada materi penjumlahan bilangan pecahan serta
2) untuk mengetahui upaya guru meminimalisir kesulitan yang dialami siswa kelas IV SDN II Sudimoro dalam menyelesaikan soal matematika materi penjumlahan bilangan pecahan. Penelitian ini menggunakan pendekatan kualitatif dan jenis penelitian deskriptif. Subjek penelitian adalah guru kelas IV , guru kelas V dan siswa. Teknik pengumpulan data adalah menggunakan observasi, wawancara dan dokumentasi. Data dianalisis dengan menggunakan reduksi data, penyajian data dan menarik kesimpulan. Hasil penelitian ini menunjukkan bahwa: (1) jenis- jenis kesulitan yang dialami siswa diantaranya: (a) kelemahan dalam pemahaman bahasa yang kurang, (b) kelemahan dalam mentransfer pengetahuan, dan (c) kelemahan pada saat menghitung. (2) Upaya yang di lakukan Guru dalam meminimalisir kesulitan yang dialami siswa yaitu dengan; (a) Memberi Motivasi Belajar dengan di berikan motivasi, maka siswa akan lebih bersemangat dalam proses pembelajaran, (b) Memberi variasi metode mengajar dengan memberikan variasi mengajar, (c) lebih memahami materi yang telah di sampaikan oleh Guru sebelumnya, (d) mempergunakan alat peraga dengan mempergunakan alat peraga dengan contoh kalau untuk matematika ini menggunakan proyektor dengan kartu pecahan maka siswa akan lebih paham dan mudah dalam penangkapan materi, (e) memberikan program perbaikan atau remedial.
Analisis Kesalahan dalam Mengerjakan Soal Matematika Berdasarkan Prosedur Newman
Authors: Kuncoro Anggun Dwi , Qudsiyah Khoirul , Hidayat Taufik 
Published: June 2022

Penelitian ini bertujuan u ntuk mengetahui kes alahan s is wa dalam mengerjakan s oal es ay berdas arkan Newman Error Analys is (NEA). Penelitian ini merupakan penelitian kualitatif s tudi kas us . Pengambilan s ampel menggunakan purposive sampling. Subjek penelitian ini adalah s is wa kelas VIII C SMP N 3 Tulakan tahun ajaran 2019/2020 s ebanyak
28 s is wa. Ins trumen yang digunakan pada penelitian ini berupa tes , dan wawancara.
Sedangkan analis is data yang digunakan Miles Huberman. Bentuk kes alahan s is wa berdas arkan Newman’s Error (NEA) adalah s ebagai berikut; 1) readings error, s is wa tidak menulis kan apa yang diketahui dalam s oal karena tidak membaca perintah s oal dengan baik.
2) comprehensions error, s is wa tidak menulis kan apa yang ditanyakan dalam s oal karena tidak memahami perintah s oal dengan baik. 3) transformations error, s is wa tidak menulis kan rumus dengan benar karena tidak memahami materi. 4) processing sk ill error, s is wa s alah menghitung karena tidak teliti. 5) encoding error, s is wa tidak menulis kan kes impulan karena pada tahap s ebelumnya telah terjadi kesalahan.
Induction and maintenance of mouse totipotent stem cells by a defined chemical cocktail
Authors: Hu Yanyan , Yang Yuanyuan , Ma Tianhua , Liu Kang , Ding Sheng 
Published: June 2022

Abstract
In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem cells (TotiSCs), capable of producing all cell types in both embryonic and extraembryonic tissues and forming an entire organism1. However, it remains challenging whether and how TotiSCs, representing the very beginning of a life, can be established in vitro in the absence of germline cells. Here, we described a step-by-step protocol for induction and long-term maintenance of TotiSCs from mouse pluripotent stem cells (PSCs) by a small-molecule combination of TTNPB, 1-Azakenpaullone, and WS6. These chemically induced totipotent stem cells, designated as ciTotiSCs, resembled mouse totipotent 2C-embryo stage cells at transcriptome, epigenome and metabolome level. In addition, ciTotiSCs exhibited bidirectional developmental potentials and were able to produce both embryonic and extraembryonic cells in vitro and in teratoma. Furthermore, following injection into 8-cell embryo, ciTotiSCs contributed to both embryonic and extraembryonic lineages with high efficiency. Our chemical approach for TotiSCs induction and maintenance provides a defined in vitro system to manipulate and understand totipotent state towards creating life from non-germline.
Video-assisted Bystander Cardiopulmonary Resuscitation Improves the Quality of Chest Compressions during Simulated Cardiac Arrests: A Systemic Review and Meta-Analysis
Authors: Pan Dongfeng , Li Zhengjun , Ji Xinzhong , Yang Liting , Liang PF 
Published: June 2022

Abstract
Background
It remains unclear whether video aids can improve the quality of bystander CPR. Therefore, we summarized the simulation-based studies aiming at improving bystander CPR associated with the quality of chest compressions and time-related quality parameters.
Methods
The systematic review was conducted according to the PRISMA guidelines. All relevant studies were searched through PubMed, EMbase, Medline and Cochrane Library databases. The risk of bias was evaluated using the Cochrane collaboration tool.
Results
A total of 259 studies were eligible for inclusion, and 6 RCT studies were ultimately included. Meta-analysis results indicated that V-CPR was significantly associated with the improved mean chest compression rate [OR = 0.66 (0.49–0.82), P < 0.001] and the proportion of chest compressions with correct hand positioning [OR = 1.63 (0.71–2.55), P < 0.001]; However, the difference in mean chest compression depth was not statistically significant [OR = 0.18 (-0.07–0.42), P = 0.15], and V-CPR was not associated with the time to first chest compression compared to T-CPR [OR = -0.12 (-0.88–0.63), P = 0.75].
Conclusion
Video real-time guidance by dispatcher can improve the quality of bystander CPR to a certain extent. However, the quality is still not ideal, and there is a lack of guidance caused by poor video signal or inadequate interaction.
Outcome of Pulpotomy in Permanent Teeth with Irreversible Pulpitis: A Systematic Review and Meta-Analysis
Authors: Ather Amber , BDS Biraj Patel , Gelfond Jonathan A. L. , Ruparel Nikita B. 
Published: June 2022

Abstract
Treatment planning is key to clinical success. Permanent teeth diagnosed with “irreversible pulpitis” have long been implied to have an irreversibly damaged dental pulp that is beyond repair and warrantingroot canal treatment. However, newer clinical approaches such as pulpotomy, a minimally invasive and biologically based procedure have re-emerged to manage teeth with pulpitis. The aim of the study was to conduct a meta-analysis to comprehensively estimate the overall success rate of pulpotomy in permanent teeth with irreversible pulpitis. Articles were searched using PubMed, Scopus, CENTRAL, and Web of Science databases, until January 2021. Outcomes were calculated by pooling the success rates with a random effect model. A total of 1,116 records were retrieved and 11 studies were included in the quantitative analysis. The pooled success rate for pulpotomy in teeth with irreversible pulpitis was 86% [95% CI: 0.76–0.92; I2 = 81.9%]. Additionally, prognostic indicators of success were evaluated. Stratification of teeth based on 1.) symptoms demonstrated that teeth with symptomatic and asymptomatic irreversible pulpitis demonstrated success rate of 84% and 91% respectively, with no significant difference (p = 0.18) using z-score analysis; 2.) open apex teeth demonstrated a significantly greater success rate (96%) compared to teeth with closed apex (83%) (p = 0.02), and 3.) pulp capping materials demonstrated that Biodentine demonstrated significantly better success rates compared to Mineral Trioxide Aggregate (MTA), calcium hydroxide, and Calcium Enriched Mixture (CEM.) Collectively, this is the first meta-analytical study to determine accurate prediction of clinical outcomes of pulpotomy for teeth with irreversible pulpitis. Moreover, we identify the stage of root development and type of biomaterial as predictors for success of pulpotomy.