bluuebunny/crossref_metadata_2025_split huggingface dataset:
Underwater optical wireless communication performance enhancement using 4D 8PAM trellis-coded modulation OFDM with DFT precoding
Authors: Xu Lin , He Jing , Zhou Zhihua , Xiao Yaoqiang 
Published: March 2022

A 4D 8-pulse amplitude modulation trellis-coded modulation-based orthogonal frequency division multiplexing (4D 8PAM TCM-OFDM) scheme combined with discrete Fourier transform (DFT) precoding is proposed and experimentally demonstrated in an underwater optical wireless communications system. It can resist power fading caused by the attenuation, scattering, and reflection in the water channel. The experimental results show that, after transmission over the water–air channel and at the bit error rate of

3.8

×

1

0

−
3

, the improvement in the receiver sensitivity is 0.88 dB using the 4D 8PAM TCM-OFDM scheme, compared to the conventional 64QAM-OFDM scheme. In addition, the proposed 4D 8PAM TCM-OFDM scheme combined with DFT precoding can compensate for unbalanced impairments, and it can obtain 1.28 dB receiver sensitivity improvement, compared to the conventional 64QAM-OFDM scheme with DFT precoding.
Factors associated with in-hospital mortality of adult tetanus patients–a multicenter study from Bangladesh
Authors: Khan Md. Abdullah Saeed , Hasan Mohammad Jahid , Rashid Md. Utba , Kha Sagar Soumik , Khan Sanzida , Zaman Susmita , Sumon Sultan Mahamud , Basher Ariful , Hawlader Mohammad Delwer Hossain , Nabi Mohammad Hayatun , Kakoly Nadira Sultana 
Published: March 2022

Background
Tetanus, a vaccine-preventable disease, is still occurring in the elderly population of low- and middle-income countries with a high case-fatality rate. The objective of the study was to elucidate the factors associated with in-hospital mortality of tetanus in Bangladesh.

Methods
This prospective observational study, conducted in two specialized infectious disease hospitals, conveniently selected adult tetanus patients (≥18 years) for inclusion. Data were collected through a preformed structured questionnaire. Kaplan Meier survival analysis and univariate and multivariable Cox regression analysis were carried out to assess factors associated with in-hospital mortality among patients. All analysis was done using Stata (version 16) and SPSS (version 26).

Results
A total of 61 tetanus cases were included, and the overall in-hospital mortality rate was 34.4% (n = 21). Patients had an average age of 46.49 ±15.65 years (SD), and the majority were male (96.7%), farmers (57.4%), and came from rural areas (93.4%). Survival analysis revealed that the probability of death was significantly higher among patients having an age of ≥ 40 years, incubation time of ≤12 days, onset time of ≤ 4 days, and having complication(s). However, on multivariable Cox regression analysis, age (adjusted hazard ratio [aHR] 4.03, 95% Confidence Interval [CI] 1.07–15.17, p = 0.039) and onset time (≤4 days) (aHR 3.33; 95% CI 1.05–10.57, p = 0.041) came as significant predictors of in-hospital mortality after adjusting for incubation period and complications.

Conclusion
Older age and short onset time are the two most important determinants of in-hospital mortality of tetanus patients. Hence, these patients require enhanced emphasis and care.
Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid—Preventive therapies for people living with HIV
Authors: Müller Pia , Velez Lapão Luís 
Published: March 2022

Background
Cotrimoxazole and isoniazid preventive therapy (CPT, IPT) have been shown to be efficacious therapies for the prevention of opportunistic infections and tuberculosis (TB) among people living with human immunodeficiency virus (HIV). Despite governments’ efforts to translate World Health Organization recommendations into practice, implementation remains challenging. This review aimed to explore and compare CPT and IPT with respect to similarities and differences of barriers identified across high TB/HIV burden countries. A secondary objective was to identify facilitators for implementing both preventive therapies.

Methods
We searched MEDLINE, Web of Science and SCOPUS databases for peer-reviewed literature published before September 2020. We extracted and synthesized our findings using Maxqda software. We applied framework synthesis in conjunction with metasummary to compare both therapies with respect to similarities and differences of barriers identified across seven health system components (in line with the modified WHO’s Framework for action). Protocol registration: PROSPERO (CRD42019137778).

Findings
We identified four hundred and eighty-two papers, of which we included forty for review. Although most barrier themes were identical for both preventive therapies, we identified seven intervention-specific themes. Like for CPT, barriers identified for IPT were most frequently classified as ‘service delivery-related barriers’ and ‘patient & community-related barriers’. ‘Health provider-related barriers’ played an important role for implementing IPT. Most facilitators identified referred to health system strengthening activities.

Conclusions
For researchers with limited working experience in high TB/HIV burden countries, this review can provide valuable insights about barriers that may arise at different levels of the health system. For policymakers in high TB/HIV burden countries, this review offers strategies for improving the delivery of IPT (or any newer therapy regimen) for the prevention of TB. Based on our findings, we suggest initial and continuous stakeholder involvement, focusing on the efficient use and reinforcement of existing resources for health.
Towards better reliability in fetal heart rate variability using time domain and spectral domain analyses. A new method for assessing fetal neurological state?
Authors: Zizzo Anne Rahbek , Kirkegaard Ida , Uldbjerg Niels , Hansen John , Mølgaard Henning 
Published: March 2022

Objectives
Fetal heart rate variability (FHRV) has shown potential in fetal surveillance. Therefore, we aimed to evaluate the reliability of time domain and spectral domain parameters based on non-invasive fetal electrocardiography (NI-FECG).

Method
NI-FECG, with a sampling frequency of 1 kHz, was obtained in 75 healthy, singleton pregnant women between gestational age (GA) 20+0 to 41+0. The recording was divided into a) heart rate pattern (HRP) and b) periods fulfilling certain criteria of stationarity of RR-intervals, termed stationary heart rate pattern (SHRP). Within each recording, the first and the last time series from each HRP with less than 5% artifact correction were analyzed and compared. Standard deviation of normal-to-normal RR-intervals (SDNN), root mean square of successive differences (RMSSD), high frequency power (HF-power), low frequency power (LF-power), and LF-power/HF-power were performed. A multivariate mixed model was used and acceptable reliability was defined as intraclass correlation coefficient (ICC) ≥ 0.80 and a coefficient of variation (CV) ≤ 15%. Based on these results, the CV and ICC were computed if the average of two to six time series was used.

Results
For GA 28+0 to 34+6, SDNN and RMSSD exhibited acceptable reliability (CV < 15%; ICC > 90%), whereas GA 35+0 to 41+0and 20+0 to 27+6 showed higher CVs. Spectral domain parameters also showed high CVs However, by using the mean value of two to six time series, acceptable reliability in SDNN, RMSSD and HF-power from GA 28+0 was achieved. Stationarity of RR-intervals showed high influence on reliability and SHRP was superior to HRP, whereas the length of the time series showed minor influence.

Conclusion
Acceptable reliability seems achievable in SDNN, RMSSD and HF-power from gestational week 28. However, stationarity of RR-intervals should be considered when selecting time series for analyses.
Integrated RNA gene expression analysis identified potential immune-related biomarkers and RNA regulatory pathways of acute myocardial infarction
Authors: Shao Guangyao 
Published: March 2022

BackgroundAcute lesions are among the most important causes of death due to vascular lesions worldwide. However, there are no accurate genetic markers for Acute myocardial infarction (AMI). This project will use microarray integration analysis in bioinformatics analysis to find and validate relevant AMI gene markers.MethodsFive microarray gene expression datasets were downloaded through the GEO database. We identified 50 significant DEGs by comparing and analyzing gene expression between 92 AMI and 57 standard samples. The BioGPS database screened differentially expressed genes specific to the immune system. DEGs were mainly involved in immune-related biological processes based on Enrichment analysis. Eight hub genes and three-gene cluster modules were subsequently screened using Cytoscape and validated using Box plot’s grouping comparison and ROC curves. Combined group comparison results and ROC curves analysis concluded thatAQP9,IL1B, andIL1RNmight be potential gene markers for the AMI process. We used the StarBase database to predict target miRNAs for eight essential genes. The expected results were used to screen and obtain target lncRNAs. Then Cytoscape was used to create CeRNA networks. By searching the literature in PubMed, we concluded thatAQP9,IL1B, andIL1RNcould be used as gene markers for AMI, whileFSTL3-miR3303p-IL1B/IL1RNandACSL4-miR5905p-IL1Bcould be used as RNA regulatory pathways affecting AMI disease progression.ConclusionsOur study identified three genes that may be potential genetic markers for AMI’s early diagnosis and treatment. In addition, we suggest thatFSTL3-miR-330-3p-IL1B/IL1RNandACSL4-miR-590-5p-IL1Bmay be possible RNA regulatory pathways to control AMI disease progression.
Knowledge, behaviours and attitudes towards Evidence-Based Practice amongst physiotherapists in Poland. A nationwide cross-sectional survey and focus group study protocol
Authors: Płaszewski Maciej , Krzepkowska Weronika , Grantham Weronika , Wroński Zbigniew , Makaruk Hubert , Trębska Joanna 
Published: March 2022

Objectives
Evidence-Based Practice, EBP, is recognised, along with team work and patient-centred care, as a core competency in contemporary healthcare. However, dissemination and implementation of EBP remains problematic and is dependent on various external and internal factors, from personal through institutional to systemic, factors, with specific characteristics for different professions, contexts and settings. Knowledge, behaviours, attitudes, as well as facilitators and barriers towards EBP amongst physiotherapists, have been widely explored worldwide, but never in Poland. This study is part of a nationwide project, including dissemination actions addressing EBP in physiotherapists registered in Poland. Our purpose is to explore the issues of knowledge, behaviours, experiences, and attitudes of physiotherapists in Poland towards EBP. Descriptive research studies are warranted before analytical investigations and dissemination activities are conducted.

Methods
We plan to conduct a quantitative, cross-sectional study–an online survey amongst the total population of physiotherapists registered in Poland to assess knowledge, behaviours and use of EBP (Study 1), and a qualitative study to allow physiotherapists to voice their opinions and to explore their experiences and attitudes towards EBP (Study 2). The EBP2 questionnaire, Polish validated translation, will be used for Study 1, in a web-based survey. A focus group approach will be applied for Study 2, with purposive sampling to achieve a representative picture of physiotherapists with respect to setting, specialty, seniority, educational degrees, and age. We will follow an inductive approach, using topics rather than questions.

Results
We will present the results of the studies separately, as typically presented in relevant study types: Study 1 will be reported addressing the domains and items of the EBP2, in relation to the independent variables, and Study 2 will be discussed using the themes and illustrative quotes analyses.

Discussion
We are aware that significant non-response, spin and Hawthorne effect may potentially bias our findings.
Secondary postpartum hemorrhage: Incidence, etiologies, and clinical courses in the setting of a high cesarean delivery rate
Authors: Chainarong Natthicha , Deevongkij Kittiya , Petpichetchian Chusana 
Published: March 2022

Objectives
To evaluate the incidence, etiologies, and clinical outcomes of secondary postpartum hemorrhage in a hospital with a high cesarean section rate and to compare the etiologies of secondary postpartum hemorrhage following cesarean delivery versus vaginal delivery.

Materials and methods
This retrospective study included 123 women with secondary postpartum hemorrhage who were treated at a tertiary-level hospital between January 2004 and June 2018. Descriptive statistics and the chi-square test were used for data analysis.

Results
The incidence of secondary postpartum hemorrhage was 0.21%. The median onset of bleeding was 12 days after delivery. Fifty-two percent of the deliveries were by cesarean section. The most common etiology of secondary postpartum hemorrhage was endometritis (67.5%), followed by retained placental tissue (21.1%). Women who delivered by cesarean section had a higher rate of endometritis (80.0% vs 53.4%) and a lower rate of retained placental tissue (10.8% vs. 32.8%) than those who delivered vaginally. Surgical intervention included uterine evacuation in 29.3% and hysterectomy in 8.1% of the patients. Five percent of women were treated by embolization.

Conclusions
Endometritis was the most common cause of secondary postpartum hemorrhage. Women who delivered by cesarean section were less likely to have retained placental tissue but were at higher risk for endometritis and uterine pseudoaneurysm than those who delivered vaginally.
Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018
Authors: Donfrancesco Chiara , Profumo Elisabetta , Lo Noce Cinzia , Minutoli Daniela , Di Lonardo Anna , Buttari Brigitta , Vespasiano Francesca , Vannucchi Serena , Galletti Ferruccio , Onder Graziano , Colivicchi Furio , Galeone Daniela , Bellisario Paolo , Palmieri Luigi 
Published: March 2022

Background/Objectives
Obesity is associated with an increased risk of noncommunicable diseases, such as diabetes, coronary heart disease, stroke, cancers, and conditions, including obstructive sleep apnea and osteoarthritis. Obesity is largely preventable, and halting its rise is one of the World Health Organization Global Action Plan for the Prevention of Noncommunicable Diseases targets. This study aimed to assess trends of anthropometric measurements in Italy using the data collected within the CUORE Project health examination surveys (HESs) 1998, 2008, and 2018.

Subjects/Methods
Within the HESs 1998–2002, 2008–2012, and 2018–2019, anthropometric measurements were collected in random samples of the resident population aged 35–74 years, stratified by age and sex, from 10 Italian Regions in Northern, Central, and Southern Italy (2984 men and 2944 women, 2224 men and 2188 women, 1035 men and 1065 women, respectively). Weight, height, and waist and hip circumferences were measured using standardized methodologies. A standardized questionnaire was used to collect data on education. Indicators were age standardized.

Results
For both men and women, mean body mass index in 2018 was comparable with those in 1998 and 2008 (in 1998, 2008, and 2018—men: 26.7, 27.5, and 27.0 kg/m2; women: 26.2, 26.6, and 26.3 kg/m2). In 1998, 2008, 2018 prevalence of overweight resulted 49%, 47%, 46% in men and 33%, 32%, 28% in women respectively; prevalence of obesity resulted 17%, 24% 20% in men and 19%, 23%, 23% in women respectively. All indicators of excess weight worsen with increasing age and are more severe in persons with a lower educational level.

Conclusions
Although the overall trend of excess weight over the past two decades appeared to be substantially stable in the Italian adult population, the continuous strengthening of undertaken initiatives should continue since there remains a high proportion of overweight or obesity and a gap between educational levels.
Hubungan Gaya Hidup dengan Kesehatan Mental Remaja di Indonesia (Analisis Data Global School-Based Student Health Survey Indonesia 2015)
Authors: Pratiwi Silfia Dini , Djuwita Ratna 
Published: March 2022

Background: Mental health disorders are one of the main risk factors for causing pain and death in adolescents. Symptoms of mental health disorders can be anxiety, depression, sleep disorders, suicidal or self-harm ideas and attempted suicide. Poor mental health is a severe health problem, especially in adolescents. Mental health is affected by multiple factors, including daily behavior and individual lifestyle.Methods: This study aimed to find out the relationship between lifestyle and mental health of adolescent in Indonesia. This study used secondary data of Indonesia's Global School-Based Student Health Survey in 2015. The population of this study was 9.628 students aged 11-18 years in Indonesia. This research sample was obtained by total sampling method. This study used multivariate analysis of cox regression and large associations expressed with Prevalence Ratio (PR) with 95% Confidence Interval.Result: The prevalence of adolescents in Indonesia with mental health disorders is 9,4%. Multivariate analysis test results showed there was a significant relationship between lifestyle and adolescent mental health in Indonesia (PR= 1,47, 95% CI: 1,31 – 1,65) after being controlled by gender, socioeconomic status, and bullying.Conclusion: The school and parents are advised to work together to prevent mental health disorders in adolescents.
circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury
Authors: Zhu Jiang , Zhong Fukuan , Chen Futao , Yang Yang , Liao Yingying , Cao Lifeng , Zhou Yong , Bai Qiaohong 
Published: March 2022

Abstract
Acute lung injury (ALI) is a respiratory disorder characterized by acute respiratory failure. circRNA mus musculus (mmu)-circ_0001679 was reported overexpressed in septic mouse models of ALI. Here the function of circ_0001679 in sepsis-induced ALI was investigated. In vitro models and animal models with ALI were, respectively, established in mouse lung epithelial (MLE)-12 cells and C57BL/6 mice. Pulmonary specimens were harvested for examination of the pathological changes. The pulmonary permeability was examined by wet-dry weight (W/D) ratio and lung permeability index. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in the bronchoalveolar lavage fluid (BALF), the lung tissues, and the supernatant of MLE-12 cells were measured by enzyme linked immunosorbent assay . Apoptosis was determined by flow cytometry. Bioinformatics analysis and luciferase reporter assay were used to assess the interactions between genes. We found that circ_0001679 was overexpressed in lipopolysaccharide (LPS)-stimulated MLE-12 cells. circ_0001679 knockdown suppressed apoptosis and proinflammatory cytokine production induced by LPS. Moreover, circ_0001679 bound to mmu-miR-338-3p and miR-338-3p targeted dual-specificity phosphatases 16 (DUSP16). DUSP16 overexpression reversed the effect of circ_0001679 knockdown in LPS-stimulated MLE-12 cells. Furthermore, circ_0001679 knockdown attenuated lung pathological changes, reduced pulmonary microvascular permeability, and suppressed inflammation in ALI mice. Overall, circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR-338-3p/DUSP16 axis.
Combatting persisted and biofilm antimicrobial resistant bacterial by using nanoparticles
Authors: Hemeg Hassan A. 
Published: March 2022

Abstract
Some bacteria can withstand the existence of an antibiotic without undergoing any genetic changes. They are neither cysts nor spores and are one of the causes of disease recurrence, accounting for about 1% of the biofilm. There are numerous approaches to eradication and combating biofilm-forming organisms. Nanotechnology is one of them, and it has shown promising results against persister cells. In the review, we go over the persister cell and biofilm in extensive detail. This includes the biofilm formation cycle, antibiotic resistance, and treatment with various nanoparticles. Furthermore, the gene-level mechanism of persister cell formation and its therapeutic interventions with nanoparticles were discussed.
A Novel Test Method for the Determination of Delayed Ettringite Formation in Mass Concrete
Authors: Paris Jerry M. , Ferraro Christopher C. , Kennedy Danielle E. , Bentivenga Anthony , Scott D. B. 
Published: March 2022

Abstract
Delayed ettringite formation in concrete structures can develop long after they are placed into service; this deleterious reaction is particularly difficult to predict because of the extended time before becoming symptomatic. However, once discovered, it is known to impact durability and drastically reduce service life. This research presents a novel test method developed for mortars to represent concretes that experience high early-age temperature profiles to determine the potential for delayed ettringite formation in mass concrete. To more accurately replicate exposure conditions of typical mass concrete placements, this novel method exposes specimens to a rapid heat acceleration and soaking period at 95 °C and 95 % relative humidity for an extended period of time followed by storage in a calcium hydroxide solution at room temperature. This results in a reduction of the dormancy period before onset of delayed ettringite formation while minimizing laboratory resources. A further benefit of the test is the reduction of the induction period typically associated with delayed ettringite formation. The method has proved to be valuable, as it allows for the rapid determination the potential of supplementary cementitious materials to mitigate delayed ettringite formation.