bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cultural evolutionary behavior genetics will need a more sophisticated conceptualization of cultural traits
Authors: Syed Moin , Nguyen Phuong Linh L. 
Published: September 2022

Abstract
A framework that brings together cultural perspectives and behavior genetics has long been needed. To be successful, however, we need sophistication in the conceptualization of culture. Here, we highlight three imperatives to this end: the need for a clear definition of cultural traits, inclusion of the role of societal power, and recognizing the distinction between traits and characteristic adaptations.
Going West: Socialist flexibility in the long 1970s
Authors: Cucu Alina-Sandra 
Published: September 2022

AbstractThis article analyses some of the transformations in economic vocabularies, practices, and institutions that accompanied the turn towards high value-added and technology-driven industrialization in late socialist Romania. It investigates the challenges posed by increasing integration of the country’s commodity production into the world market in the 1960–70s and assesses the measures adopted by its economic executives as a response to these challenges: the reorganization of production; the reconfiguration of planning mechanisms; and the strategies of keeping labour cheap. This article shows that planners behind the Iron Curtain wrestled with similar problems to their Western counterparts. It demonstrates that the solutions of the socialist economic executives not only mirrored, imitated, and translated Western managerial ideologies and practices but also represented creative local responses to the challenges of the world market. I argue this constellation of solutions constituted a fully fledged form of ‘socialist flexibility’. Analysing how these flexible solutions paralleled the neoliberal deregulation in the capitalist core helps us question the analytical separation between centrally planned and market economies and the still powerful narrative of 1989 as a historical fracture.
Theorizing the history of women's international thinking at the ‘end of international theory’
Authors: Owens Patricia , Dunstan Sarah C. , Hutchings Kimberly , Rietzler Katharina 
Published: September 2022

AbstractThroughout the 20thcentury, women were leading intellectuals on International Relations (IR). They thought, wrote, and taught on this subject in numerous political, professional, intimate, and intellectual contexts. They wrote some of the earliest and most powerful theoretical statements of what would later become core approaches to contemporary international theory. Yet, historical women, those working before the late 20thcentury, are almost completely missing in IR's intellectual and disciplinary histories, including histories of its main theoretical traditions. In this forum, leading historians and theorists of IR respond to the recent findings of the Leverhulme project on Women and the History of International Thought (WHIT), particularly its first two book-length publications on the centrality of women to early IR discourses and subsequent erasure from its history and conceptualization. The forum is introduced by members of the WHIT project. Collectively, the essays suggest the implications of the erasure and recovery of women's international thought are significant and wide-ranging.
Lake Ice Will Be Less Safe for Recreation and Transportation Under Future Warming
Authors: Woolway R. Iestyn , Huang Lei , Sharma Sapna , Lee Sun‐Seon , Rodgers Keith B. , Timmermann Axel 
Published: September 2022

AbstractMillions of lakes from around the world freeze during winter. These frozen surfaces provide essential ecosystem services that are vital to many northern communities. However, the availability of safe lake ice that is oftentimes required to support these services is under threat from climate change. Here we use a 100‐member ensemble of climate model simulations to investigate changes in the presence of safe lake ice for different recreation and provisioning activities across the Northern Hemisphere. Our projections suggest that the duration of safe ice for recreational purposes will shorten, on average, by 13, 17, and 24 days within a 1.5°C, 2°C, and 3°C warmer world (relative to 1900–1929), respectively. The projected change in the duration of safe ice will be greater in higher latitudes, but with the most densely populated lower‐latitude regions experiencing the greatest percent change. The use of lake ice to support critical transportation infrastructure will also be influenced by future warming through the loss of thicker ice this century. However, our projections suggest that the magnitude of change in the duration of safe ice will differ depending on the ice thickness requirements. For transportation that requires the thickest ice cover, the number of days with safe ice will decline by 90%, 95%, and 99% with 1.5°C, 2°C, and 3°C global warming, respectively. We highlight the need for the development and implementation of adaptation plans to address the imminent loss of critical wintertime transportation infrastructure across the Northern Hemisphere.
Mountain Rivers Reveal the Earthquake Hazard of Geologic Faults in Silicon Valley
Authors: Aron Felipe , Johnstone Samuel A. , Mavrommatis Andreas , Sare Robert , Maerten Frantz , Loveless John P. , Baden Curtis W. , Hilley George E. 
Published: September 2022

AbstractThe 1989, Mw = 6.9 Loma Prieta earthquake resulted in tens of lives lost and cost California almost 3% of its gross domestic product. Despite widespread damage, the earthquake did not clearly rupture the surface, challenging the identification and characterization of these hidden hazards. Here, we show that they can be illuminated by inverting fluvial topography for slip‐and moment accrual‐rates—fundamental components in earthquake hazard assessments—along relief‐generating geologic faults. We applied this technique to thrust faults bounding the mountains along the western side of Silicon Valley in the San Francisco Bay Area, and discovered that these structures may be capable of generating a Mw = 6.9 earthquake every 250–300 years based on moment accrual rates. This method may be deployed broadly to evaluate seismic hazard in developing regions with limited geological and geophysical information.
Structure and Evolution of Northern Juan de Fuca Crust and Uppermost Mantle Over the Last 8 Ma From an Active‐Source Seismic Tomography Study
Authors: Boulahanis Bridgit , Carbotte Suzanne M. , Canales Juan Pablo , Han Shuoshuo , Nedimović Mladen R. 
Published: September 2022

AbstractWe present results from a two‐dimensional wide‐angle controlled source seismic transect designed to characterize the velocity structure of the oceanic crust and uppermost mantle spanning the northern Juan de Fuca (JdF) plate from near Endeavor ridge to the Cascadia margin. Reflection and refraction travel time inversion is used to derive a tomographic Vp model of sediments, crust, and upper mantle. Velocity model results are compared to baseline reference Vp values for unaltered crustal and upper mantle rocks at temperatures assuming plate cooling. Effective medium theory is used to infer the degree of hydration of the crust and mantle. Results indicate a somewhat fractured and hydrated upper crust (≤2.5 wt% water), a near dry lower crust (≤0.7 wt%) and upper mantle (≤0.5 wt%) west of the deformation front, and an ∼75 km wide region of modestly lower velocity in the mid‐plate. Comparison with prior results from a complementary transect offshore Oregon indicates significant differences in Vp of the upper crust, with lower Vp‐inferred porosity along most of the Washington transects that may reflect different extents of fault‐related alteration and sediment burial histories. Approaching the deformation front, Washington transect Vp structure indicates dryer conditions than offshore Oregon, consistent with differences in extent of subduction bend faulting found in reflection imaging studies. On both transects, quasi‐abrupt changes in plate properties at ages of 8, 6, and 3.4/4 Ma are found. Distinct crustal accretion modes are recognized, aligning with changes in JdF plate motion and recent history of Cobb‐Eickelberg hotspot influence on crustal accretion at the JdF ridge.
Investigation of Effects of Near‐Surface Complexities on Measurement of Mantle Discontinuity Using SS and Its Precursors
Authors: Wang Peifeng , Zhou Yong , Xu Min , Zhang Han , Chen Xiaofei , Guo Laiyin 
Published: September 2022

AbstractSeismic observations of the mantle discontinuities at depths of 410 and 660 km provide crucial information to constrain the thermal and compositional states and further shape our understanding of mantle dynamics. The topography and impedance contrast of the mantle discontinuities, at both global and regional scales, have been imaged through differential travel times and amplitude ratios between SS and its precursors. However, a relatively simple reference phase (SS) is often assumed, which may overlook potential bias caused by near‐surface complexities. To assess these effects, we developed an algorithm to simulate the waveforms of SS and its precursors efficiently based on the propagation matrix method. We found that the crustal thickening increases the differential travel times but does not change the amplitude ratios much, while the sedimentary layer significantly affects both the differential travel times and amplitude ratios. The global anomalies of differential travel times and amplitude ratios are mapped incorporating earth models from CRUST1.0 and PREM. The time shift can reach ∼9 s, which will bring a depth bias of mantle discontinuity of more than 20 km, while the amplitude ratio anomaly is up to ∼40%, which will make the impedance contrast of the mantle discontinuity overestimated. The near‐surface complexities cannot be ignored in the investigation of mantle discontinuities with SS precursors, especially when the bounce points located in the regions with sediment.
A Prediction Model of Relativistic Electrons at Geostationary Orbit Using the EMD‐LSTM Network and Geomagnetic Indices
Authors: Zhang H. , Xu H. R. , Peng G. S. , Qian Y. D. , Zhang X. X. , Yang G. L. , Shen C. , Li Z. , Yang J. W. , Wang Z. Q. , He F. , Gu C. L. , Zhu M. B. 
Published: September 2022

AbstractIn this study, the Empirical Mode Decomposition algorithm (EMD) and the Long Short Term Memory neural network (LSTM) are combined into an EMD‐LSTM model, to predict the variation of the >2 MeV electron fluxes 1 day ahead. Input parameters include the Pc5 power, AP, AE, Kp, >0.6 MeV, and historical electron flux values, are used for predictions. All the time resolution of parameters are daily integral values. As compared the prediction results of the EMD‐LSTM model with other classical prediction models, the results show that the 1 day ahead prediction efficiency of the >2 MeV electron fluxes possesses a prediction efficiency of 0.80, and the highest prediction efficiency can reach 0.93. These results are superior to the prediction accuracy of more previous models. Using two high‐energy electron flux storm events for validation, the results indicate that the performance of the EMD‐LSTM model in the period of the high‐energy electron flux storm is also relatively good, especially for the prediction of high‐energy electron fluxes at extreme points, and the predictions are closer to actual observations.
Identity-by-descent analysis of CMTX3 links three families through a common founder
Authors: Henden Lyndal , Grosz Bianca R. , Ellis Melina , Nicholson Garth A. , Kennerson Marina , Williams Kelly L. 
Published: September 2022

AbstractA large 78 kb insertion from chromosome 8q24.3 into Xq27.1 was identified as the cause of CMTX3 in three families of European descent from Australia (CMT193, CMT180) and New Zealand/United Kingdom (CMT623). Using the relatedness tool XIBD to perform genome-wide identity-by-descent (IBD) analysis on 16 affected individuals from the three families demonstrated they all share the CMTX3 disease locus identical-by-descent, confirming the mutation arose in a common ancestor. Relationship estimation from IBD segment data has genetically linked all three families through 6th and 7th degree relatives.
TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP-363856
Authors: Saarinen Marcus , Mantas Ioannis , Flais Ivana , Ågren Richard , Sahlholm Kristoffer , Millan Mark J. , Svenningsson Per 
Published: September 2022

AbstractSEP-363856 (SEP-856) is a novel antipsychotic under clinical development. It displays a unique pattern of receptor interaction, with only weak (partial agonist) activity at dopamine D2 receptors, yet more potent agonist activity at the trace amine associated receptor (TAAR1) and 5-hydroxytryptamine 1 A receptor (5-HT1A). Nonetheless, these observations await independent confirmation and more detailed characterization of the in vitro and in vivo actions of SEP-856 at TAAR1 and 5-HT1A receptors would be instructive. Herein, we employed luminescence complementation technology in heterologous live cell systems, confocal microscopy, voltage clamp electrophysiology, behavioral readouts and TAAR1 knockout (KO) mice to study SEP-856 in further detail. We provide evidence for the ability of SEP-856 to activate TAAR1 at the surface plasma membrane, and show that this interaction results in Gαs recruitment (pEC50: 6.08 ± 0.22 EMAX: 96.41% ± 15.26) and by extension, to G-protein inwardly rectifying potassium (GIRK) channel activation. Using TAAR1-KO mice, we find TAAR1 to be indispensable for SEP-856 control of body temperature, baseline locomotion reduction and for “antipsychotic-like” efficacy as characterized by a reversal of dizocilipine (MK-801) mediated disruption of pre-pulse inhibition. Conversely, the inhibition by SEP-856 of MK-801 induced locomotion was unaffected in TAAR1 KO mice. SEP-856 behaved as a low-potency, partial agonist at the 5-HT1A receptor, while it partially inhibited recruitment of D2 receptor-coupled Gα and GIRK by DA and acted as a weak partial agonist with low potency at the same receptor when applied alone. Our findings corroborate and extend previous observations on the molecular substrates engaged by this unique, dual TAAR1/5-HT1A receptor agonist and potential antipsychotic that could prove to have major advantages in the treatment of schizophrenia and other psychotic disorders.
Differences in outcomes after total hip arthroplasty for osteoarthritis between patients with and without central sensitivity syndromes other than fibromyalgia
Authors: Ohashi Yoshihisa , Fukushima Kensuke , Uchida Kentaro , Koyama Tomohisa , Tsuchiya Maho , Saito Hiroki , Uchiyama Katsufumi , Takahira Naonobu , Inoue Gen , Takaso Masashi 
Published: September 2022

AbstractWe investigated the differences in outcomes after total hip arthroplasty (THA) for hip osteoarthritis (HOA) between patients with and without central sensitivity syndromes (CSSs) other than fibromyalgia (FM). After excluding two patients with FM, we compared the clinical data of 41 patients with CSSs and 132 patients without CSSs. Clinical data included scores on the central sensitization inventory, visual analog scale for pain (VAS pain), and Japanese Orthopedic Association Hip Disease Evaluation Questionnaire (JHEQ). VAS pain was significantly higher at 3 and 6 months after THA in patients with CSSs than in those without CSSs (3 and 6 months, P < 0.001). Satisfaction, pain, and mental JHEQ scores were lower in patients with CSSs than in those without CSSs (satisfaction, P < 0.001; pain, P = 0.011; mental, P = 0.032). Multiple regression analyses indicated that one and ≥ 2 CSS diagnoses significantly impacted the satisfaction score (one CSS, β = − 0.181, P = 0.019; ≥ 2 CSSs, β = − 0.175, P = 0.023). Two or more CSSs were the only factor influencing the pain score (β = − 0.175, P = 0.027). Pain in patients with CSSs reflects central sensitization, which may adversely affect post-operative outcomes. Surgeons should pay attention to patients with a history of CSSs diagnoses who undergo THA for HOA.
Clinical significance of matrix metalloproteinase-9 in Fragile X Syndrome
Authors: Laroui Asma , Galarneau Luc , Abolghasemi Armita , Benachenhou Sérine , Plantefève Rosalie , Bouchouirab Fatima Zahra , Lepage Jean François , Corbin François , Çaku Artuela 
Published: September 2022

AbstractHigh plasma matrix metalloproteases-9 (MMP-9) levels have been reported in Fragile X Syndrome in a limited number of animal and human studies. Since the results obtained are method-dependent and not directly comparable, the clinical utility of MMP-9 measurement in FXS remains unclear. This study aimed to compare quantitative gel zymography and ELISA and to determine which method better discriminates abnormal MMP-9 levels of individuals with FXS from healthy controls and correlates with the clinical profile. The active and total forms of MMP-9 were quantified respectively, by gel zymography and ELISA in a cohort of FXS (n = 23) and healthy controls (n = 20). The clinical profile was assessed for the FXS group using the Aberrant Behavior Checklist FXS adapted version (ABC-CFX), Adaptive Behavior Assessment System (ABAS), Social Communication Questionnaire (SCQ), and Anxiety Depression and Mood Scale questionnaires. Method comparison showed a disagreement between gel zymography and ELISA with a constant error of − 0.18 [95% CI: − 0.35 to − 0.02] and a proportional error of 2.31 [95% CI: 1.53 to 3.24]. Plasma level of MMP-9 active form was significantly higher in FXS (n = 12) as compared to their age-sex and BMI matched controls (n = 12) (p = 0.039) and correlated with ABC-CFX (rs = 0.60; p = 0.039) and ADAMS (rs = 0.57; p = 0.043) scores. As compared to the plasma total form, the plasma MMP-9 active form better enables the discrimination of individuals with FXS from controls and correlates with the clinical profile. Our results highlight the importance of choosing the appropriate method to quantify plasma MMP-9 in future FXS clinical studies.
Efficacy of administrative intervention for neurosurgical patients with off-label use of alprostadil lipid microsphere
Authors: Luo Yuling , Fan Qingze , Yu Yongqi , Zhang Lunhui , Dong Limei , Luo Hongli 
Published: September 2022

AbstractAs an adjuvant drug, alprostadil lipid microsphere injection (Lipo-PGE1) is one of the best-selling drugs in China in recent years. However, the off-label use of Lipo-PGE1 is very common. This study aimed to investigate the use of Lipo-PGE1 and evaluate the clinical effects and economic benefits after administrative intervention on inappropriate use of Lipo-PGE1 in neurosurgical patients in a Chinese tertiary hospital. Administrative interventions were implemented from January to December 2018 by reducing the procurement volume of Lipo-PGE1, judging the rationality of medical records, and establishing reward and punishment mechanisms. Administrative interventions significantly decreased prescription rate (49.98% vs 22.49%), utilization (22,311 DDDs vs 8334 DDDs), drug use density (43.52 DDDs/TID vs 15.84 DDDs/TID), total expenditure (3.58 million RMB vs 1.30 million RMB), and average expenditure (2025.04 RMB vs 1466.49 RMB) of Lipo-PGE1. To our delight, these intervention effects were maintained or even better in the 1-year post-intervention period. Moreover, in the intervention and post-intervention phases, the Lipo-PGE1 use for no indications as well as inappropriate drug dose, frequency, menstruum type, combination, and contraindication were markedly reduced. Besides, the mean costs (P < 0.001), and mean duration (P < 0.001) of Lipo-PGE1 were also obviously decreased. The administrative intervention obviously reduced the off-label use of Lipo-PGE1. However, there still remains a number of inappropriate uses of Lipo-PGE1. To further improve the rational use of Lipo-PGE1, combination of administrative intervention and real-time clinical pharmacists intervention should be implemented.
Clinical characteristics and a 2-year follow-up of unsatisfactory conventional Pap smears: a retrospective case–control study
Authors: Tien Chin-Tzu , Li Pei-Chen , Chen Chi-Jui , Ding Dah-Ching 
Published: September 2022

AbstractThe objective of this study was to conduct a 2-year follow-up of individuals having unsatisfactory reports of Pap smears and to analyze the contributing factors. This was a retrospective study at a medical center that performed about 5000–6000 Pap smears annually in Eastern Taiwan. Women who had unsatisfactory results due to scant cellularity between January 1, 2015–December 31, 2016, were included in this study. The control group comprised age-matched women with normal Pap smears at a 1:4 ratio, during the same period. The clinical characteristics and the 2-year outcomes were followed. Patients who were unavailable for follow-up assessments or who had insufficient clinical information were excluded. Student’s t-test and chi-square test were used for continuous and categorical variables, respectively. Statistical significance was defined as a p-value < 0.05. A total of 887 Pap smears were included. A total of 717 and 170 women had normal Pap and unsatisfactory Pap tests, respectively. After excluding women who were unavailable for follow-up, the final analysis included 248 and 67 women with normal and unsatisfactory Pap tests, respectively. The mean age was not significantly different between the two groups (49.97 ± 10.69 and 51.61 ± 11.28 years in the unsatisfactory Pap and control groups, respectively [p > 0.05]). The percentage of menopause and vaginal discharge were significantly different between the two groups. Multivariate analysis revealed that premenopausal status, increased discharge were associated with the risk of unsatisfactory Pap tests. Of the 67 women with unsatisfactory Pap tests, all tested negative for any malignancies at a 2-year follow-up assessment. Women with increased vaginal discharge and without menopause were at an increased risk of having an unsatisfactory Pap test. Our results indicate that an unsatisfactory Pap smear due to scant cellularity might not increase the risk of intraepithelial neoplasia or cancer after 2 years. Further, large-scale studies with longer follow-up periods are required.
Flexible cyanoethyl cellulose-based nanocomposites with superior energy storage capability
Authors: Wu Lukang , Zhao Jinhao , Li Zhicheng , Zhai Yizan , Zhang Yiling , Zhen Qiongxuan , Cheng Yu , Ding Xiangping , Li Peng , Liu Jinjun , Pan Zhongbin 
Published: September 2022

Novel 2D BNNs/cyanoethyl cellulose composite films exhibit a large Ud of 23.5 J cm−3 along with a high η of 83.6% at 680 MV m−1.
A bistatic inverse synthetic aperture radar sparse aperture high‐resolution imaging algorithm with migration compensation
Authors: Zhu Hanshen , Hu Wenhua , Guo Baofeng , Zhu Xiaoxiu , Zhou Bin , Xue Dongfang , Zhu Chang'an 
Published: September 2022

AbstractIn recent years, bistatic inverse synthetic aperture radar (Bi‐ISAR) imaging of targets with sparse aperture has attracted more and more attention. One of the critical issues is that the Bi‐ISAR imaging of some large targets with rotational motions is prone to migration through resolution cells, which increases the imaging difficulty. In order to enhance the compensation for through resolution cell migration in those scenarios and improve the accuracy and resolution of Bi‐ISAR images under sparse aperture, that is, improving the target recognition of Bi‐ISAR, the authors aimed at the high‐order migration term and the high‐order phase error term and proposed a Bi‐ISAR sparse aperture high‐resolution imaging algorithm based on complex Bayesian compressed sensing and frequency resampling. The algorithm was solved by ‘distributed’ iteration. The migration compensation under the sparse aperture conditions was completed, and the quality of the reconstructed images was improved. Simulation results verified the effectiveness and superiority of the proposed algorithm.