bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of steroid ratios for random urine by mass spectrometry to detect 5α-reductase deficiency in Vietnamese children
Authors: Tran Thi Chi Mai , Tran Thi Ngoc Anh , Le Hoang Bich Nga , Nguyen Viet Hoa , Tran Minh Dien , Vu Chi Dung , Greaves Ronda F. 
Published: May 2022

Abstract

Objectives
The 5α-reductase-type-2 deficiency (5ARD2) is a rare autosomal recessive 46,XY disorder of sex development caused by the mutated 5α-reductase type 2 (SRD5A2) gene. In this disease, defective conversion of testosterone to dihydrotestosterone leads to variable presentations of male ambiguous genitalia during fetal development. We aimed to examine characteristics of patients presenting with 5ARD2 over a 4 year period.

Methods
Random urine samples of control and patients with suspected 5ARD2 were collected and urine steroidomic metabolites were measured by Gas chromatography-mass spectrometry (GC-MS) in the period from 2017 to 2021 at National Children’s Hospital, Hanoi Vietnam. 5α- to 5β-reduced steroid metabolite ratio, 5a-tetrahydrocortisol to tetrahydrocortisol (5α-THF/THF), was reviewed by receive operator characteristics (ROC) curve analysis. Molecular testing was offered to 25 patients who were diagnosed with 5ARD2 by GC-MS urinary steroid analysis.

Results
Urine steroidomic profiling was conducted for 104 male controls and 25 patients between the ages of 6 months and 13 years old. Twelve of the twenty-five 5ARD2 patients agreed to undertake genetic analysis, and two mutations of the SRD5A2 gene were detected in each patient, confirming the diagnosis. All patients showed a characteristically low ratio of 5α-THF/THF. There was no overlap of 5α-THF/THF ratio values between control and 5ARD2 groups. The ROC of 5α-THF/THF ratio at 0.19 showed 100% sensitivity and 100% specificity for boys between 6 months and 13 years of age.

Conclusions
Analysis of the urine steroid metabolome by GC-MS can be used to assist in the diagnosis of 5ARD2. We recommend consideration of random urine steroid analysis as a first-line test in the diagnosis of 5ARD2.
Time series with infinite-order partial copula dependence
Authors: Bladt Martin , McNeil Alexander J. 
Published: May 2022

Abstract
Stationary and ergodic time series can be constructed using an s-vine decomposition based on sets of bivariate copula functions. The extension of such processes to infinite copula sequences is considered and shown to yield a rich class of models that generalizes Gaussian ARMA and ARFIMA processes to allow both non-Gaussian marginal behaviour and a non-Gaussian description of the serial partial dependence structure. Extensions of classical causal and invertible representations of linear processes to general s-vine processes are proposed and investigated. A practical and parsimonious method for parameterizing s-vine processes using the Kendall partial autocorrelation function is developed. The potential of the resulting models to give improved statistical fits in many applications is indicated with an example using macroeconomic data.
Intramuscular hydatid cyst of thigh masquerading as a soft tissue tumour diagnosed by fine needle aspiration cytology
Authors: Amita K , Rajini T , Sanjay M , Abhishek MG , Prashantha K 
Published: May 2022

Abstract
Introduction. Hydatid cyst, caused by Echinococcus granulosa, occurs rarely in the musculoskeletal region. Most of the time, clinically and radiologically it is diagnosed as a soft tissue tumor, benign or malignant. There are a few case reports of hydatid cyst presenting as an intramuscular thigh mass, which has been diagnosed at fine needle aspiration cytology (FNAC). Accurate pre-operative diagnosis is essential in view of specific therapeutic options for this disease. Here we report a case of hydatid cyst occurring in an unusual location (thigh) and masquerading as a soft tissue tumour, diagnosed at FNAC. Case Report. 56-year-old male patient presented with gradually increasing swelling of the left thigh since 3 years. On examination, there was a firm non-tender 25 × 20 cm swelling on the posterior aspect of left thigh extending from the gluteal region to five cm above the knee joint. An ultrasound diagnosis of a soft tissue tumor was made. At FNAC, fluid was aspirated and smears showed granulomas along with multiple hyaline acellular membrane-like fragments, few showing vague laminations. A diagnosis of hydatid cyst was made at FNAC which was corroborated at histopathology. Conclusion. Intramuscular hydatid cyst of the thigh is a very rare manifestation. The possibility of hydatid cyst should be considered while aspirating any soft tissue mass lesion, especially when fluid is obtained and microscopy shows acellular hyaline membrane-like material, even when fewer laminations are noted.
Fabrication of CsPb1−x
Mn
x
Br3−2x
Cl2x
(x = 0–0.5) quantum dots for near UV photodetector application
Authors: Tran Ba-Duc , Tran Phuong-Nam , Bui Xuan-Thanh , Nguyen Duy-Hung , Duong Thanh-Tung 
Published: May 2022

Abstract
In this study, CsPb1–x
Mn
x
Br3–2x
Cl2x
(x = 0–0.5) nanoparticles were synthesized directly in toluene solvents at high temperature. This approach results in small-size nanoparticles, which can be used in photoelectric components without adding a filtration process to eliminate high-temperature solvents such as octadecene. The high content Mn2+-incorporated CsPb(Cl/Br)3 host is observed by strongly wideband emission at 592 nm of manganese d-states spin and orbital forbidden transition. After infiltration into mesoporous TiO2, the Mn2+ ion receives energy from the CsPb(Cl/Br)3 host (irradiated 405 nm light-emitting diode source) and effectively transfers to the TiO2 scaffold layer. As a result, a metal/semiconductor/metal planar structure photodetector with m-TiO2/CsPb1–x
Mn
x
Br3–2x
Cl2x
(x = 0–0.5) composite showed several figures of merit compared to bare m-TiO2 and m-TiO2/CsPbBr3 such as on/off ratio of 104 times, responsivity of 1.67 A·W−1, and detectivity of 4.42 × 109 Jones. The key factors contributing to the growth of the on/off ratio include the decreasing dark current and enhancing exciton energy and transportation due to the infiltration of CsPb1–x
Mn
x
Br3–2x
Cl2x
(x = 0–0.5) perovskite quantum dots into mesopores of the m-TiO2 scaffold layer.
Metal-exchanged phosphotungstate nanoparticles with improved acidity as the catalyst for esterification of glycerol with acetic acid
Authors: Ertaş Mert Can , Akbay Elif 
Published: May 2022

Abstract
A series of metal-exchanged phosphotungstate salts, Fe-TPA, Cr-TPA, Cu-TPA, and Ni-TPA were synthesized by sonication and tested for glycerol esterification with acetic acid to obtain biofuel additives. A systematic, chemical, structural, and morphological characterization and determination of acidity were used by various analytical techniques. XRD and FT-IR studies confirmed the Keggin structure of all metal exchanged phosphotungstate salts with no impurities coming from metal nitrate salts. The incorporation of metal cations in phosphotungstic acid leads to decreased crystallite size as seen from XRD diffractograms. N2 adsorption-desorption analysis showed that the Type II isotherms were obtained for all metal exchanged phophostungstate salts, characteristic of non-porous or macroporous materials. SEM images of metal exchanged phosphotungstate salts displayed well-shaped crystalline particles. SEM-EDX analysis showed that the calculated tungsten metal ratios are in good agreement with the theoretical ratios of those for all the metal exchanged salts, verified by XRF results. The exchange of protons by the metal cations improved the thermal stability observed in the TGA analysis. The acidity strengths, from NH3-TPD analysis, were found in the following order; TPA > Fe-TPA > Cr-TPA > Cu-TPA. Additionally, pyridine-FTIR gives that the exchanging of transition metal into the phosphotungstic acid decreased the Brønsted acidity while increasing the Lewis acidity and this mostly affects the efficiency of the esterification reaction. The activity of metal exchanged salts was in the given order; Fe-TPA > Cr-TPA > Cu-TPA > Ni-TPA. Among these Fe-TPA salt, having a good ratio of Brønsted and Lewis acidity, have the selectivity for di- and triacetin (68 and 10%), with the highest conversion (96%). The iron phosphotungstate salts are a promising catalyst with sustainable Bronsted acidity during the reaction, high desired product selectivity at low temperature, easy synthesizability, inexpensive, and environmentally friendly.
First record of polydactyly for a European bat, Myotis daubentonii (Chiroptera, Vespertilionidae)
Authors: Torrent Laura , Apoznański Grzegorz , Kokurewicz Tomasz , Mitrus Cezary , De Maegdt Maya , Juste Javier 
Published: May 2022

Abstract
Despite being one of the most common congenital hand abnormalities in humans, polydactyly remains extremely rare in bats. To date, it has been observed only in two insectivorous families in North America (Molossidae and Vespertilionidae) and a single case for the New World fruit bats (Phyllostomidae). We report the first case of polydactyly in a European bat – a Myotis daubentonii (Vespertilionidae), with eight toes. The bat was found alive, hibernating in the Natura 2000 site (PLH080003 “Nietoperek”) in Poland.
‘Maybe if you talk to her about it’: intensive mothering expectations and heritage language maintenance
Authors: Torsh Hanna Irving 
Published: May 2022

AbstractMaintaining heritage languages is frequently desired by migrants to continue cultural and social connections to family and identity. However, in imagined monolingual nations such as Australia, efforts to transmit minority languages are seen as a private matter and largely unsupported. Transmission of culture and language is also frequently seen as women’s work (Heller, Monica & Laurette Lévy. 1992. Mixed marriage: Life on the linguistic frontier.Multilingua11(1). 32). This article seeks to explore how linguistically intermarried heterosexual couples orient to the task of heritage language maintenance along gender lines. It draws on a qualitative interview-based study into 22 couples living in Sydney. For the English-speaking background parents in the study, pressure to raise bilingual children arising out of a discourse ofintensive mothering(Hays, Sharon. 1996.The cultural contradictions of motherhood. New Haven: Yale University Press) was experienced in more negative ways by mothers than fathers. The analysis points to the effects of the non-migrant partner’s first language and their gender on heritage language efforts in linguistically intermarried families, and their impact on the (dis)continuation of linguistic diversity.
The Garden: blending in the semiotics of songs
Authors: Brandt Per Aage , Cronquist Ulf 
Published: May 2022

Abstract
After giving some contextual information, we propose an analysis of music and meaning in the song “The Garden,” as performed by the rock group Einstürzende Neubauten in the official video from the 1996 release of the album Ende Neu. We present a semiotic blending model of the narrative content of the song and of its imagery, partly determined by the structure and character of the music. Finally, we add a view of the apocalyptic perspective of some comparable creations.
The coherence function and its information content for optical metrology
Authors: Bergmann Ralf B. , Fischer Andreas , Bockelmann Carsten , Dekorsy Armin , Garcia-Ortiz Alberto , Falldorf Claas 
Published: May 2022

Abstract
The coherence function offers new possibilities for optical metrology that are not available with conventional wave field sensing. Its measurement involves a spatio-temporal sampling of the wave fields modulated by the object under investigation. Temporal sampling is well known e. g. by means of White Light Interferometry (WLI) and spatial sampling can e. g. performed by Computational Shear Interferometry (CoSI). The present paper describes an approach that combines both temporal and spatial sampling using a robust common-path setup. While the evaluation of the coherence function is more elaborate than approaches that either sample the temporal or the spatial domain, an information theoretical treatment shows that it also delivers more information about the object under investigation. Our approach is based on the mutual information that represents the reduction of uncertainty about the object as a consequence of the measurements performed. Using a simplified measurement case, we calculate the mutual information for different measurement situations and demonstrate that spatio-temporal sampling of the coherence function results in a higher mutual information as compared to classical approaches. Based on the proposed approach, we identify further open research tasks for an efficient information extraction from the coherence function to surpass current limitations of optical metrology.
Responses to Song Playback Differ in Sleeping versus Anesthetized Songbirds
Authors: Bottjer Sarah W. , Le Moing Chloé , Li Ellysia , Yuan Rachel 
Published: May 2022

AbstractVocal learning in songbirds is mediated by a highly localized system of interconnected forebrain regions, including recurrent loops that traverse the cortex, basal ganglia, and thalamus. This brain-behavior system provides a powerful model for elucidating mechanisms of vocal learning, with implications for learning speech in human infants, as well as for advancing our understanding of skill learning in general. A long history of experiments in this area has tested neural responses to playback of different song stimuli in anesthetized birds at different stages of vocal development. These studies have demonstrated selectivity for different song types that provide neural signatures of learning. In contrast to the ease of obtaining responses to song playback in anesthetized birds, song-evoked responses in awake birds are greatly reduced or absent, indicating that behavioral state is an important determinant of neural responsivity. Song-evoked responses can be elicited during sleep as well as anesthesia, and the selectivity of responses to song playback in adult birds is highly similar between anesthetized and sleeping states, encouraging the idea that anesthesia and sleep are similar. In contrast to that idea, we report evidence that cortical responses to song playback in juvenile zebra finches (Taeniopygia guttata) differ greatly between sleep and urethane anesthesia. This finding indicates that behavioral states differ in sleep versus anesthesia and raises questions about relationships between developmental changes in sleep activity, selectivity for different song types, and the neural substrate for vocal learning.
ПОБУДОВА МОДЕЛЕЙ ІДЕНТИФІКАЦІЇ ТЕХНІЧНОГО СТАНУ ЕЛЕМЕНТІВ АВТОМАТИКИСИСТЕМ ЖИВЛЕННЯ РАКЕТНИХ ДВИГУНІВ
Authors: Пономарьов О.М. 
Published: May 2022

The article presents the results of the development of diagnostic models of automation elements of liquid-propellant rocket engine power systems. A functional model of a pneumatic valve has been developed, which provides that it is subjected to mechanical action from moving elements, and oscillations in the form of vibration and acoustic waves are observed at the output. The paper presents the results of studies of the dynamics of the mechanical system, which is represented by the valve under study, a mathematical model of the valve closing process, which is a reliable display of the valve&#39;s operating characteristics, which it reproduces. The model
describes the relationship of the equation of the dynamics of the moving parts of the valve and the occurrence of forced vibrations in its structure and associated elements
Empatia fenomenológica
Authors: Castro Gillianno José Mazzetto de 
Published: May 2022

O presente artigo tem como objetivo produzir um estudo sobre a empatia a partir da perspectiva fenomenológica. Para tanto, será feita uma distinção entre os vários sentidos e usos da palavra “empatia” na contemporaneidade. Logo após, serão analisadas as várias teorias e modelos explicativos da empatia a partir da investigação de “como” a consciência humana acessa o mundo externo. Dentre os modelos explicativos explorados, destacam-se o modelo Theory – Theory (TT), o Simulation Theory (ST), o Integrated Theory (IT), o Graded Empathy Hypothesis (GEH) e o Reintegrated Theory (RT). Feito isso, será explorada, mais detidamente, a proposta fenomenológica para a questão da empatia. Por fim, se buscará, à luz da perspectiva fenomenológica, avançar na reflexão sobre a empatia a partir de três ideias: a de ressonância, a de afetação e a de interimplicação, buscando desenvolver os primeiros passos para uma interintencionalidade imanente. Como limites e possibilidades, pode-se notar que é preciso explorar mais os processos de modalização da empatia no processo de constituição do ego, principalmente da vida pré-egótica.
Pemantauan Suhu dan Deteksi Gerak Obyek Berbasis IoT pada Ruang Server Menggunakan Thinger.IO
Authors: Bakri Muhammad Amin , Farhan Muhammad , Sujatmiko Aeri , Firasanti Annisa 
Published: May 2022

Server memiliki peran vital dalam kelangsungan bisnis. Oleh karena itu, parameter ruang server seperti suhu dan kelembapan penting untuk dipantau untuk kepentingan pemeliharaan. Berbeda dengan penelitan sejenis terdahulu, penelitian ini bertujuan merancang sistem pemantauan suhu dan kelembapan, serta deteksi gerak objek pada ruang server secara real-time dengan memanfaatkan aplikasi Thinger.io. Metode perancangan perangkat pemantauan ruang server dibangun dari satu microcontroler, satu sensor suhu dan kelembapan, serta sensor gerakan obyek dan kamera. Luaran dari sensor diproses oleh Node MCU sebelum dikirim ke internet menggunakan Thinger.io. Selanjutnya, data hasil pemantauan tersebut ditampilkan di browser dan smartphone. Hasil pengujian menunjukkan bahwa perangkat pemantauan yang telah dirancang memiliki kinerja yang baik. Pembacaan suhu yang dikirimkan Thinger.io ke internet melalui browser dan smartphone memiliki selisih 0,39°C. Sementara pengiriman notifikasi peringatan suhu di luar standar berhasil dikirimkan via email dan pesan telegram. Pengiriman notifikasi adanya gerakan objek juga berhasil dikirimkan via email serta pengiriman foto objek terdeteksi melalui telegram bot. Waktu pengiriman notifikasi adalah 13 detik untuk email dan 23 detik untuk telegram bot. The server has a vital role in business continuity. Therefore, server room parameters such as temperature and humidity are important to monitor for maintenance purposes. In different to previous similar research, this study aims to design a temperature and humidity monitoring system and detect object motion in the server room in real-time using Thinger, io application. The design method of the server room monitoring device is built from a microcontroller, a temperature and humidity sensor, an object movement sensor, and a camera. The output of the sensor is processed by the Node MCU before being sent to the internet by using Tinger.io. Furthermore, the monitoring data is displayed in browsers and smartphones. The implementation results show that the device that has been designed has good performance. The temperature measurement that Thinger.io sends to the internet via a browser and then smartphone has a difference of 0,39°C. Meanwhile, the sending of temperature warning notification outside of the standard was successfully sent via email and telegram massage. Notification of objects was also successfully sent via email and photos of detected objects were sent via telegram bot. Notification delivery time takes13 seconds for email and takes 23 seconds for telegram bot.
Undergraduate dentistry student’s perception on objective structured practical examination (OSPE): A cross-sectional study
Authors: Radke Sulabha A , Wankhade Jyoti S , Manekar Varsha Sunil , Warhadpande Manjusha , Dakshindas Darshan , Khatri Sachin 
Published: May 2022

Assessment for practical skills in dental education needs improvement from subjective methods to objective ones. An OSPE has been considered as one such method. This study is an attempt to evaluate the feasibility of OSPE as a tool for the formative assessment of undergraduate medical education in Dental Material. Thirty-two students of Second BDS, at the end of the first term, were assessed by both the conventional practical examination (CPE) and OSPE. A five-station question based & practical skill evaluation based OSPE was conducted one week after the conventional examination in Department of Conservative Dentistry and Endodontics of our institute. The scores obtained in both exams by these thirty-two students were compared. Feedback of participating students was evaluated in this interventional study. The steps involved were Sensitization of faculty and students; Preparation of five OSPE stations; Preparation phase and content validation of questionnaire for students. Feedback was given to students which will be useful to them in their subsequent and final university exams. The difference in marks was insignificant when paired t test was applied. Regarding the students’ perceptions of OSPE when compared to CPE, 78% responded that OSPE could partially or completely replace CPE. OSPE was judged as an objective and unbiased assessment as compared to CPE, by 84% of the students.
Modelo Integral de Evaluación de Proveedores de Servicios de Mantenimiento con Énfasis en la Seguridad
Authors: Valdez Martínez Ludy Magnolia , Martínez Rodríguez Myriam Araceli , Silva y Rodríguez García Beatriz Eugenia , Guerrero Posadas Martín 
Published: May 2022

El objetivo fue desarrollar un modelo para evaluar de manera integral el desempeño de proveedores de servicios de mantenimiento con énfasis en la seguridad. La investigación tuvo un enfoque cualitativo y el tipo de diseño fue el estudio de caso de caso de una empresa automotriz dedicada al diseño y desarrollo de chasis. Se utilizó la observación, entrevista a profundidad y grupos focales. Finalmente, se diseñaron los elementos del modelo que consta de cuatro instrumentos para evaluar el desempeño de los proveedores de servicios: (a) por parte del área de compra, (b) mantenimiento, (c) seguridad e higiene y (d) para evaluar a la propia empresa por parte de los proveedores. Además, el modelo se compone de la herramienta para el seguimiento de incidencias del servicio y la evaluación integral del servicio. La validación de instrumentos la hicieron gerentes de las áreas de compras, producción, seguridad e higiene y de la planta.
Uniwersytet trzeciego wieku – uczy, integruje i aktywizuje
Authors: Palma Agnieszka 
Published: May 2022

Głównym celem artykułu jest przedstawienie i przybliżenie instytucji, jaką jest uniwersytet trzeciego wieku, zwrócenie uwagi na jego funkcje edukacyjną, integracyjną i aktywizującą w życiu osób starszych, a także określenie stojących przed nim wyzwań w obliczu nasilającego się procesu starzenia się społeczeństwa. Zachodzące zmiany demograficzne wpływają na zwiększenie zainteresowania tematyką osób starszych i starzenia się społeczeństwa, ale przede wszystkim skłaniają do jak największej aktywizacji osób starszych poprzez umożliwianie im kontaktów z rówieśnikami, zaspokajanie potrzeby samorozwoju, kształcenia się, a przede wszystkim zdobywania nowych umiejętności. Taką możliwość dają osobom starszym uniwersytety trzeciego wieku. Ich dynamiczny rozwój w Polsce i pozytywne zmiany, jakie niosą one zarówno dla samych seniorów, jak i dla społeczności lokalnych, przysłaniają problemy, z jakimi mierzą się one w codziennej działalności.