bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND): Protocol for a Prospective Study
Authors: Diepstraten Franciscus A , Meijer Annelot JM , van Grotel Martine , Plasschaert Sabine LA , Hoetink Alexander E , Fiocco Marta , Janssens Geert O , Stokroos Robert J , van den Heuvel-Eibrink Marry M 
Published: February 2022

BackgroundSome children with central nervous system (CNS) and solid tumors are at risk to develop ototoxicity during treatment. Up to now, several risk factors have been identified that may contribute to ototoxicity, such as platinum derivates, cranial irradiation, and brain surgery. Comedication, like antibiotics and diuretics, is known to enhance ototoxicity, but their independent influence has not been investigated in childhood cancer patients. Recommendations for hearing loss screening are missing or vary highly across treatment protocols. Additionally, adherence to existing screening guidelines is not always optimal. Currently, knowledge is lacking on the prevalence of ototoxicity.ObjectiveThe aim of the Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND) is to determine the feasibility of audiological testing and to determine the prevalence and determinants of ototoxicity during treatment for childhood cancer in a national cohort of patients with solid and CNS tumors.MethodsThe SOUND study is a prospective cohort study in the national childhood cancer center in the Netherlands. The study aims to include all children aged 0 to 19 years with a newly diagnosed CNS or solid tumor. Part of these patients will get audiological examination as part of their standard of care (stratum 1). Patients in which audiological examination is not the standard of care will be invited for inclusion in stratum 2. Age-dependent audiological assessments will be pursued before the start of treatment and within 3 months after the end of treatment. Apart from hearing loss, we will investigate the feasibility to screen patients for tinnitus and vertigo prevalence after cancer treatment. This study will also determine the independent contribution of antibiotics and diuretics on ototoxicity.ResultsThis study was approved by the Medical Research Ethics Committee Utrecht (Identifier 20-417/M). Currently, we are in the process of recruitment for this study.ConclusionsThe SOUND study will raise awareness about the presence of ototoxicity during the treatment of children with CNS or solid tumors. It will give insight into the prevalence and independent clinical and cotreatment-related determinants of ototoxicity. This is important for the identification of future high-risk patients. Thereby, the study will provide a basis for the selection of patients who will benefit from innovative otoprotective intervention trials during childhood cancer treatment that are currently being prepared.Trial RegistrationNetherlands Trial Register NL8881; https://www.trialregister.nl/trial/8881International Registered Report Identifier (IRRID)DERR1-10.2196/34297
Effectiveness of a new smartphone application on type 1 diabetes control and self-management in times of Covid-19: Prospective comparative study (Preprint)
Authors: Derkaoui Nada , Benyakhlef Salma , Rami Imane , Elmehraoui Ouafae , Charif Hajar , Messaoudi Najoua , Bouichrat Nisrine , Assarrar Imane , Tahri Abir , Derbel Salma , Abda Naima , Rouf Siham , Latrech Hanane 
Published: February 2022

BACKGROUND

Background: Self-management for type 1 diabetes mellitus patients is a real challenge especially in a time of a spreading pandemic. “Ana wa Soukari” is a newly designed smartphone application for therapeutic education and insulin doses management.

OBJECTIVE

Objectives: Our study evaluated the effectiveness of “Ana wa Soukari” on clinical and biological outcomes of type 1 diabetes self-management.

METHODS

Methods: This is a prospective comparative study including 62 patients. Primary study endpoint was HbA1c after three months’ follow-up. Secondary study endpoints were number of hypoglycaemic events and diabetes treatment satisfaction. Treatment satisfaction was assessed using the Arabic version of DTSQs questionnaire.

RESULTS

Results: Sixty-two patients were included in our study. The mean age of our patients was 15 6,41 years. Sex ratio M/F = 1,1. Mean diabetes duration was 4,9 4,3 years and 67,7% of patients had diabetes for less than 5 years. Mean HbA1c levels in Group A (with application) and Group B (without application) dropped from 8,3% 2,3 and 8,2% 2 respectively at baseline to 7,4% 1,5 and 8% 1,8 at three months’ follow-up. Change in hypoglycaemic episodes was – 1,8 2,0 (P < 0,001) for Group A and – 1,2 1,5 (P < 0,001) for Group B. DTSQs was performed in both groups at end point. Scores were significantly higher in group (A) than in group (B) with a mean score of 31,8 3,4 and 28,4 3,8 respectively (P < 0,001).

CONCLUSIONS

Conclusions: Self-management smartphone apps appear to be effective on glycaemic control and should be considered as an adjuvant intervention to the standard diabetes care.

CLINICALTRIAL
Una aventura didáctica por internet
Authors: Simón Ruiz Cristina 
Published: February 2022

Cuando el año pasado la profesora Emma Jiménez me invitó a participar en esta aventura, acepté casi de inmediato, aunque algunas dudas sobre los resultados que obtendríamos me atenazaban los nervios.
La idea original era poner en contacto, vía intemet, a mis estudiantes de redacción en español, segunda lengua (L2), nivel III, con los estudiantes de la profesora Emma para que compartieran parte de su proceso de adquisición y reflexionaran sobre él, sobre todo en lo que respecta a las diferencias entre adquirir una L2 y una lengua extranjera (L3). Sin embargo, sufrimos una primera decepción, pues mis estudiantes, aduciendo sobre todo el hecho de no tener un acceso personal a la red en México, rechazaron la invitación.
Entonces, surgió la idea de virar nuestros planteamientos iniciales y poner en contacto a los alumnos del curso de Formación de Profesores de Español como L2 LE con los estudiantes canadienses y, adelantándome a las conclusiones, puedo decir que los resultados son alentadores.
En primer lugar, hay que aclarar que los objetivos iniciales cambiaron, obviamente. Lo que decidimos lograr fue, por una parte, que los futuros profesores de español como L2/E empezaran a reflexionar sobre los problemas de adquisición del español como LE por un grupo de alumnos bastante homogéneo y con una misma lengua materna: el francés. Por otra parte, pretendíamos que los alumnos canadienses establecieran un contacto directo con hispanohablantes que no fueran sus profesoras de español y, a través de un contacto directo y personal, tuvieran la oportunidad de reflexionar sobre algunos de sus problemas con la adquisición del español, tanto en el plano gramatical como en el sociocultural.
Las elecciones federales 2021 en México: ¿plebiscitarias o identitarias?
Authors: Moreno Álvarez Alejandro 
Published: February 2022

Las elecciones de 2021 en México podrían describirse como plebiscitarias, como suelen verse las elecciones intermedias en el país, y más aún porque la aprobación de gobierno fue la variable de mayor peso en el voto, según indican los datos de una encuesta nacional de salida entre votantes. La aprobación presidencial superó en ese año a otras variables que usualmente ejercen un efecto muy significativo en el sufragio, como la identificación partidista o la identidad ideológica, lo cual sugiere que se trató de una elección en la que la evaluación del desempeño gubernamental fue fundamental. Sin embargo, la categorización como elección plebiscitaria depende del significado que atribuyamos a la aprobación presidencial. En este artículo analizamos no solamente el papel que jugó la aprobación al presidente en el voto, sino qué factores nos ayudan a entender esa variable. El resultado es que la aprobación presidencial efectivamente contiene elementos de evaluación ciudadana al quehacer gubernamental, pero también tiene componentes identitarios muy importantes que no necesariamente implican un indicador de performance o desempeño, sino de empatía y de apego identitario grupal. Esta conclusión nos invita a reflexionar sobre el carácter plebiscitario o identitario no solamente del voto en 2021, sino a repensar lo que hasta ahora la literatura sobre comportamiento electoral ha dado por sentado: el carácter evaluativo de la aprobación presidencial.
Pengembangan E-Modul Sigil Software Untuk Meningkatkan Hasil Belajar Siswa Di Masa Pandemi Covid-19
Authors: Munandar Rifki Risma , Cahyani Rusdianti , Fadilah Eva 
Published: February 2022

Learning activities are currently carried out online from home in order to prevent the spread of Covid-19. Appropriate learning alternatives are needed for students in times of pandemics. The purpose of this research is to develop e-modules of ecosystem materials that are expected to support the improvement of student learning outcomes during the Covid-19 pandemic. This research was conducted in January-July 2021 using the Research and Development (R&D) method in the ADDIE model. The client's goal of the product was tested on a limited basis to 27 class X students. The instruments used in this study are media feasibility validation sheets, learning outcome tests to measure the effectiveness of e-modules and questionnaires of student responses to developed media. The results showed that E-modules that have been developed and validated by experts get a very decent category as a learning medium with a value of 92.85% and e-modules developed can improve student learning outcomes. The conclusion obtained that the e-modules developed are feasible and effectively used as teaching materials to help students in the learning process.
Abstrak. Kegiatan pembelajaran pada saat ini dilaksanakan secara daring dari rumah dalam rangka pencegahan penyebaran Covid-19. Dibutuhkan alternatif pembelajaran yang tepat bagi siswa di masa pandemi. Tujuan penelitian ini yaitu mengembangkan bahan ajar e-modul materi ekosistem yang diharapkan dapat menunjang peningkatkan hasil belajar siswa disaat pandemi Covid-19. Penelitian ini dilaksanakan pada bulan Januari-Juli 2021 dengan menggunakan metode Research and Development (R&D) menggunakan model ADDIE. Sasaran klien dari produk hasil penelitian ini diujicobakan secara terbatas kepada siswa kelas X dengan jumlah 27 orang. Instrument yang digunakan dalam penelitian ini berupa lembar validasi kelayakan media, tes hasil belajar untuk mengukur efektivitas e-modul dan angket respon siswa terhadap media yang dikembangkan. Hasil penelitian menunjukkan bahwa E-modul yang telah dikembangkan dan divalidasi oleh ahli mendapat kategori sangat layak sebagai media pembelajaran dengan nilai 92,85% dan e-modul yang dikembangkan dapat meningkatkan hasil belajar siswa. Kesimpulan yang didapat bahwa e-modul yang dikembangkan layak dan efektif digunakan sebagai bahan ajar untuk membantu siswa dalam proses pembelajaran.
o lazer e a pessoa com deficiência física usuária de cadeira de rodas
Authors: Beltrame André Luís Normanton 
Published: February 2022

Este estudo tem como objetivo responder à seguinte pergunta: em que perspectiva se inscreve a participação social no lazer de adultos com deficiência física usuários de cadeira de rodas em cenários de microparticipação social? Para tanto, a pesquisa se envolveu com três grupos dedicados a pessoas com deficiência procurando reconhecer a configuração da participação social em termos de condições, dinâmicas e ferramentas operativas em seu universo de ação. De metodologia qualitativa e abordagem hermenêutico-dialética foram acompanhados vinte e um atores sociais e seus grupos. Os resultados apontam para condições de estrutura de poder e conflito em desfavor da pessoa com deficiência. Nota-se que as dinâmicas dos grupos os apontam capazes de favorecer a informação e a organização, porém de forma mais afetiva que instrumental. Conclui-se na necessidade de avançar em pressupostos educativos no interior dos grupos que deem conta da estrutura de poder vigente.
Characterization of phenotypes of skeletal Class III malocclusion in Korean adult patients treated with orthognathic surgery using cluster analysis
Authors: Yang Il-Hyung , Choi Jin-Young , Baek Seung-Hak 
Published: February 2022

ABSTRACT

Objectives
To characterize the phenotypes of skeletal Class III malocclusion in adult patients who underwent orthognathic surgery (OGS).

Materials and Methods
The sample consisted of 326 patients with Class III malocclusion treated with OGS (170 men and 156 women; mean age, 22.2 years). Using lateral cephalograms taken at initial visits, 13 angular variables and one ratio cephalometric variable were measured. Using three representative variables obtained from principal components analysis (SNA, SNB, and Björk sum), K-means cluster analysis was performed to classify the phenotypes. Statistical analysis was conducted to characterize the differences in the cephalometric variables among the clusters.

Results
Class III phenotypes were classified into nine clusters from the following four major groups: (1) retrusive maxilla group, clusters 7 and 9 (7.1% and 5.5%; severely retrusive maxilla, normal mandible, severe and moderate hyperdivergent, respectively) and cluster 6 (9.2%; retrusive maxilla, normal mandible, normodivergent); (2) relatively protrusive mandible group, cluster 2 (20.9%; normal maxilla, normal mandible, hyperdivergent); (3) protrusive mandible group, clusters 3 and 1 (11.7% and 15.3%; normal maxilla, protrusive mandible, normodivergent and hyperdivergent, respectively) and clusters 8 and 4 (15.3% and 3.7%; normal maxilla, severe protrusive mandible, normodivergent and hypodivergent, respectively); and (4) protrusive maxilla and protrusive mandible group, cluster 5 (11.4%; protrusive maxilla, severely protrusive mandible, normodivergent). Considerations for presurgical orthodontic treatment and OGS planning were proposed based on the Class III phenotypes.

Conclusions
Because the anteroposterior position of the maxilla and rotation of the mandible by a patient's vertical pattern determine Class III phenotypes, these variables should be considered in diagnosis and treatment planning for patients who have skeletal Class III malocclusion.
Prediction of Optimum Weld Tensile Strength Using Response Surface Methodology
Authors: Etin-Osa C. E. , Ebhota L. M. 
Published: February 2022

Metals are often subjected to various types of stresses, usually under tensile stress, quick failure of material can be encouraged especially when poor combinations of process parameters are employed in joining of the material. Tensile strength is regarded as the maximum stress that a material can sustain under tension. The aim of this study is to predict the weld tensile strength of tungsten inert gas (TIG) mild steel welds using Response Surface Methodology (RSM), with the purpose of achieving optimum results.
The input parameters considered were current, voltage, and gas flow rate. The TIG welding process was used to join two pieces of mild steel plates, after which tensile test was conducted on the specimen. The experimental result was analyzed using the RSM.
Weld Tensile test of 596.218MPa with a desirability value of 95.70% was observed to be the best, resulting from the optimized process parameters of current of 120.00 Amp, voltage of 20.00 volt and gas flow rate of 12.00 L/min.
Allocation Problems, by the Method of Alternative Representation of the Inverse Set, for Values of Cooperative TU Games
Authors: Dragan Irinel 
Published: February 2022

In earlier works, we introduced the Inverse Problem, relative to the Shapley Value, as follows: for a given n-dimensional vector L, find out the transferable utilities’ games , such that The same problem has been discussed further for Semivalues. A connected problem has been considered more recently: find out TU-games for which the Shapley Value equals L, and this value is coalitional rational, that is belongs to the Core of the game . Then, the same problem was discussed for other two linear values: the Egalitarian Allocation and the Egalitarian Nonseparable Contribution, even though these are not Semivalues. To solve such problems, we tried to find a solution in the family of so called Almost Null Games of the Inverse Set, relative to the Shapley Value, by imposing to games in the family, the coalitional rationality conditions.
In the present paper, we use the same idea, but a new tool, an Alternative Representation of Semivalues. To get such a representation, the definition of the Binomial Semivalues due to A. Puente was extended to all Semivalues. Then, we looked for a coalitional rational solution in the Family of Almost Null games of the Inverse Set, relative to the Shapley Value.
In each case, such games depend on a unique parameter, so that the coalitional rationality will be expressed by a simple inequality, determined by a number, the coalitional rationality threshold. The relationships between the three numbers corresponding to the above three efficient values have been found. Some numerical examples of the method are given.
A Review on the Latest Developments of Conducting Polymer and Composite Coatings for Enhancing Biocompatibility and Corrosion Resistance of Metallic Biomedical Implants
Authors: Mohammed Mohammed Razzaq , Radhi Safaa Hashim , Hadi Ahmed Namah 
Published: February 2022

The utilisation of metals and alloys in the biomedical field was and is still of immense importance for human life. Typically, the materials used for metallic biomedical applications, particularly those are implanted in vivo, provide appropriate mechanical and biological properties that allow them to accomplish the purpose for which they are used. Nonetheless, there are some inherent limitations impede the optimal use of these materials. One of the most crucial determinants is corrosion, which results in several other problems such as the formation of toxic substances that can not only cause necrosis of the cells attached to the implant, these toxins could also be carried by blood into body tissues and organs. This in turn leads to dire consequences on patient's life. Although a wide variety of approaches may be available to address the corrosion issue, it is alleged that coating these metals and alloys with polymers, especially the conductive ones, is among the best strategies in this regard.
This review will highlight the latest developments in using conductive polymers including polypyrrole, polyaniline, polythiophene and their composites in order to enhance biocompatibility, mechanical properties and most importantly corrosion protection performance of metallic implants. The findings obtained from coating 316L stainless steel, titanium and magnesium alloys, which have been widely manipulated in biomedical field as long and short-term implants, will be evaluated.
Application of Eigenvalues and Eigenvectors in Correlating Density and Fire Properties of Some Selected Woods in South-East Nigeria
Authors: Okafor Vincent Nwalieji , Enweonye Igwebuike , Umennadi Patrick Ugochukwu 
Published: February 2022

Data sourced from literature for wood density (WD) and fire properties for fifteen Nigerian woods were analysed. The fire properties are ignition time (IT), flame propagation rate (FPR), flame duration (FD), afterglow time (AGT), ash formation (AF) and limiting oxygen index (LOI). The aim was to correlate density and fire properties of wood using eigenvalues and eigenvectors. The analysis tool adopted was the statisticalanalysis system (SAS) where principal component and regression analyses were performed. Based on the presented data and analyses, WD was found to relate well with FPR, AGT and LOI with an adjusted R-Square = 83% while the other three parameters: IT, FD and AF constitute random noise.
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Quality Assessment of Commercially Produced Sandcrete Blocks in Okitipupa Local Government Area, Ondo State, Nigeria
Authors: Adese A. J. , Olajide O. D. 
Published: February 2022

The frequent collapse of buildings in Nigeria has necessitated carrying out a quality check not only on the structural design of these buildings but also on the materials used in their construction. Sandcrete blocks are used as a walling unit mostly because they are cheap and fast to produce. They can also be use as either load-bearing or non-load bearing purpose. Hence, this paper gives an in-depth quality assessment of sandcrete blocks commercially produced in Okitipupa Local Government Area of Ondo State, Nigeria. Six sandcrete block producing locations were visited within the local government and both six inches (6?) blocks (450×150×225 mm) and nine inches (9?) blocks (450×225×225 mm) from each location were randomly collected, together with their soil samples. Twenty-four control samples of 6? and 9? sandcrete blocks were also produced in accordance with the Nigerian Industrial Standard (NIS 87: 2007). Specific gravity test, silt/clay content and sieve analysis test were performed on each soil samples from different locations to check their suitability for block production, in addition, bulk density, compressive strength and water absorption were performed on the collected sandcrete blocks. In general, the compressive strength of the block samples was between 1.09 N/mm2 to 1.19 N/mm2 for six inches and 1.37 N/mm2 to 1.64 N/mm2 for nine inches which falls below the 2.5 N/mm2 and 3.45 N/mm2 minimum recommendation given by the NIS.
Flexural Analysis of Thick Isotropic Rectangular Plates Using Orthogonal Polynomial Displacement Functions
Authors: Dinwoke Onodagu P. , Henry Aginam C. , Franklin Uzodinma C. 
Published: February 2022

This paper analysed the flexural behaviour of SSSS thick isotropic rectangular plates under transverse load using the Ritz method. It is assumed that the line that is normal to the mid-surface of the plate before bending does not remain the same after bending and consequently a shear deformation function f (z) is introduced. A polynomial shear deformation function f (z) was derived for this research. The total potential energy which was established by combining the strain energy and external work was subjected to direct variation to determine the governing equations for the in – plane and out-plane displacement coefficients. Numerical results for the present study were obtained for the thick isotropic SSSS rectangular plates and comparison of the results of this research and previous work done in literature showed good convergence. However, It was also observed that the result obtained in this present study are significantly upper bound as compared with the results of other researchers who employed the higher order shear deformation theory (HSDT), first order shear deformation theory (FSDT) and classical plate theory (CPT) theories for the in – plane and out of plane displacements at span – depth ratio of 4. Also, at a span - depth ratio of and above, there was approximately no difference in the values obtained for the out of plane displacements and in-plane displacements between the CPT and the theory used in this study.
PENGARUH KEPEMIMPINAN KEPALA DESA TERHADAP PARTISIPASI MASYARKAT DALAM PEMBANGUNAN DESA DI DESA BONANDOLOK II KECAMATAN SIJAMAPOLANG KABUPATEN HUMBANG HASUNDUTAN
Authors: Marshalina Simamora Kristuti , Nainggolan Elizon 
Published: February 2022

Permasalahan dalam penelitian ini adalah rendahnya partisipasi masyarakat di desa terutama pada program pembangunan desa di Indonesia salah satunya disebabkan oleh faktor kepemimpinan dimana kurang maksimalnya kepemimpinan kepala desa dalam menggerakkan partisipasi masyarakat desa. Metode dalam penelitian ini adalah pendekatan deskriptif kuantitatif, dengan jumlah populasi sebanyak 501 orang, dengan sampel sebanyak 95 responden. Pengumpulan data dilakukan dengan menyebarkan Angket (Daftar Pernyataan) dan Observasi. Hasil penelitian ini menunjukan bahwa Adanya pengaruh yang signifikan antara kepemimpinan kepala desa terhadap partisipasi masyarakat dalam pembangunan desa, dengan besar pengaruh antara variabel Kepemimpinan Kepala Desa (X) terhadap Partisipasi Masyarakat Dalam Pembangunan Desa (Y) ditunjukkan adalah sebesar 34% yang diperoleh dari hasil uji koefisien determinan dimana x 100%.