bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls
Authors: Collette Christopher , Willhelm Gabrielle , Del Bene Victor A. , Aita Stephen L. , Marotta Dario , Myers Terina , Anderson Joseph , Gammon Meredith , Gerstenecker Adam , Nabors L. Burt , Fiveash John , Triebel Kristen L. 
Published: November 2022

AbstractObjectiveCognitive impairment in primary and metastatic brain cancers has been well-documented. However, there is a lack of research comparing the cognitive profiles of people with non-central nervous system (CNS) metastatic cancer versus metastatic brain cancer.MethodsThis cross-sectional study consisted of 40 non-CNS metastasis, 61 brain metastasis, and 37 healthy control (HC) participants completing the same neuropsychological test battery.ResultsBoth clinical groups had reduced processing speed, verbal learning/memory, and executive functioning. Non-CNS metastasis participants performed below HC participants on processing speed and executive functioning, while brain metastasis participants demonstrated lower performance across all neuropsychological tests. Semantic verbal fluency differentiated the two clinical groups (non-CNS metastasis>brain metastasis). Twenty-five percent of non-CNS metastasis participants and 57% of brain metastasis participants had ≥3 impaired scores (i.e., ≤5th%ile).ConclusionOne-quarter of non-CNS metastasis participants were cognitively impaired on at least three neuropsychological tests, and over half of brain metastasis participants demonstrated the same level of cognitive impairment. The elevated rate of cognitive dysfunction in the non-CNS metastasis participants is possibly attributable to systemic illness and treatment effects, while the cognitive deficits among brain metastasis participants may be associated with the more significant neurologic disease burden posed by brain metastases in conjunction with treatment effects.
Transforming a head direction signal into a goal-oriented steering command
Authors: Westeinde Elena A. , Kellogg Emily , Dawson Paul M. , Lu Jenny , Hamburg Lydia , Midler Benjamin , Druckmann Shaul , Wilson Rachel I. 
Published: November 2022

AbstractTo navigate, we must continuously estimate the direction we are headed in, and we must use this information to guide our path toward our goal1. Direction estimation is accomplished by ring attractor networks in the head direction system2,3. However, we do not understand how the sense of direction is used to guide action.Drosophilaconnectome analyses4,5recently revealed two cell types (PFL2 and PFL3) that connect the head direction system to the locomotor system. Here we show how both cell types combine an allocentric head direction signal with an internal goal signal to produce an egocentric motor drive. We recorded their activity as flies navigated in a virtual reality environment toward a goal stored in memory. Strikingly, PFL2 and PFL3 populations are both modulated by deviation from the goal direction, but with opposite signs. The amplitude of PFL2 activity is highest when the fly is oriented away from its goal; activating these cells destabilizes the current orientation and drives turning. By contrast, total PFL3 activity is highest around the goal; these cells generate directional turning to correct small deviations from the goal. Our data support a model where the goal is stored as a sinusoidal pattern whose phase represents direction, and whose amplitude represents salience. Variations in goal amplitude can explain transitions between goal-oriented navigation and exploration. Together, these results show how the sense of direction is used for feedback control of locomotion.
Demultiplexing the heterogeneous conformational ensembles of intrinsically disordered proteins into structurally similar clusters
Authors: Appadurai Rajeswari , Koneru Jaya Krishna , Bonomi Massimiliano , Robustelli Paul , Srivastava Anand 
Published: November 2022

AbstractIntrinsically disordered proteins (IDPs) populate a range of conformations that are best described by a heterogeneous ensemble. Grouping an IDP ensemble into “structurally similar” clusters for visualization, interpretation, and analysis purposes is a much-desired but formidable task as the conformational space of IDPs is inherently high-dimensional and reduction techniques often result in ambiguous classifications. Here, we employ the t-distributed stochastic neighbor embedding (t-SNE) technique to generate homogeneous clusters of IDP conformations from the full heterogeneous ensemble. We illustrate the utility of t-SNE by clustering conformations of two disordered proteins, Aβ42, and a C-terminal fragment ofα-synuclein, in their APO states and when bound to small molecule ligands. Our results shed light on ordered sub-states within disordered ensembles and provide structural and mechanistic insights into binding modes that confer specificity and affinity in IDP ligand binding. t-SNE projections preserve the local neighborhood information and provide interpretable visualizations of the conformational heterogeneity within each ensemble and enable the quantification of cluster populations and their relative shifts upon ligand binding. Our approach provides a new framework for detailed investigations of the thermodynamics and kinetics of IDP ligand binding and will aid rational drug design for IDPs.SignificanceGrouping heterogeneous conformations of IDPs into “structurally similar” clusters facilitates a clearer understanding of the properties of IDP conformational ensembles and provides insights into ”structural ensemble: function” relationships. In this work, we provide a unique approach for clustering IDP ensembles efficiently using a non-linear dimensionality reduction method, t-distributed stochastic neighbor embedding (t-SNE), to create clusters with structurally similar IDP conformations. We show how this can be used for meaningful biophysical analyses such as understanding the binding mechanisms of IDPs such asα-synuclein and Amyloidβ42 with small drug molecules.Graphical Abstract
High frequency of bedaquiline resistance in programmatically treated drug-resistant TB patients with sustained culture-positivity in Cape Town, South Africa
Authors: Derendinger B. , Dippenaar A. , de Vos M. , Huo S. , Alberts R. , Tadokera R. , Limberis J. , Sirgel F. , Dolby T. , Spies C. , Reuter A. , Folkerts M. , Allender C. , Van Rie A. , Gagneux S. , Rigouts L. , te Riele J. , Dheda K. , Engelthaler D. , Warren R. , Metcalfe J. , Cox H. , Theron G. 
Published: November 2022

AbstractIntroductionBedaquiline (BDQ) is a lifesaving new tuberculosis (TB) drug undergoing global scale-up. Data on resistance emergence in programmatic settings, especially in patients resistant to other drugs with potentially weak background regimens, is scarce. Such individuals are a priority for novel drug access yet a potential source of population-level resistance.MethodsWe collected culture isolates from 40 drug resistant (DR)-TB patients, culture-positive after ≥4 months of BDQ-based treatment at baseline (pre-BDQ treatment initiation) and follow-up (closest post-four-month isolate). We did MGIT960 (1μg/ml) BDQ drug susceptibility testing (DST), targeted deep sequencing (TDS;Rv0678, atpE, pepQ), and whole genome sequencing (WGS). Contemporaneous programmatic BDQ DST was unavailable.ResultsEight percent (3/40) of patients’ strains were BDQ resistant at baseline, and 47% (19/40) gained BDQ phenotypic resistance [88% (15/17) due to acquisition, 12% (2/17) reinfection]. Several single nucleotide polymorphisms and indels inrv0678andpepQwere associated with phenotypic resistance but none inrv0676candrv1979c(potential lineage markers). TDS detected low-level variants undetected by WGS, however, none were in genes without WGS-detected variants. Patients with baseline fluoroquinolone-resistance, clofazimine exposure, and ≤4 effective drugs were more likely to be BDQ-resistant at follow-up.ConclusionBDQ resistance acquisition, for which we identified risk factors, was common in these programmatically treated patients. Our study highlights risks associated with implementing new drugs in such populations. Likely BDQ resistance transmission occurred. Routine BDQ DST should urgently accompany scale-up of new all oral regimens, however, rapid BDQ genotypic DST remains challenging given the diversity of variants observed.
Food delivery, ghost kitchens and virtual restaurants: temporary or long-lasting game changers?
Authors: Nigro Claudio , Iannuzzi Enrica , di Santo Naomi , Sisto Roberta 
Published: November 2022

PurposeThis paper aims to investigate the phenomenon of online food purchasing in Italy and, specifically, Italian consumers' future intentions to use these services even after the end of the COVID-19 emergency. To this purpose, to understand if these phenomena are robust enough to represent irreversible and well-established trends, in the present study, consumers’ Behavioural Intention was investigated.Design/methodology/approachA theoretical framework based on a preliminary literature analysis on the use of delivery services was developed. Then, an online survey was carried out in Italy during 2021. The data were then elaborated through an exploratory factor analysis (EFA), followed by confirmatory factor analysis (CFA). Following the verification of constructs reliability, a structural equation modelling (SEM) using the statistical tools, SPSS and R (Lavaan) was performed.FindingsThe results suggest that Behavioural Intention is influenced by items such as convenience, variety of food and time savings. Moreover, the relevant role of social networks and interpersonal relationships in influencing consumers' purchasing intentions has highlighted the importance of focussing on advertising campaigns and good “word of mouth.”Originality/valueThe present research represents the first attempt to investigate the food delivery and ghost kitchens’ phenomena, recently accepted thanks to the delivery applications use in Italy, a Country with strong gastronomic tradition and with an important digital gap. In this scenario, the research focused on the attention on the consumers' future intentions to use these services even after the end of the COVID-19 emergency.
The interactive effect of mindfulness and internal listening on internal crisis management and its outcomes: the moderating role of emotional exhaustion
Authors: Adamu Adamu Abbas , Raza Syed Hassan , Mohamad Bahtiar 
Published: November 2022

PurposeInternal crisis communication (ICC) has become a burgeoning area of research in crisis communication. However, the importance of ICC as a tool to enhance employee positive communicative behaviour in crisis has not been explored. This study aims to develop a research model by drawing from the ideas of sensemaking and network theories. In addition, the study further examines how the elements of the proposed model drive ICC while assessing employee-related outcomes and the role of emotion exhaustion.Design/methodology/approachTo assess the validity of the measurement and structural models, 316 employees from both public and private non-profit organisations in Pakistan were interviewed through online survey. The collected data were analysed using co-variance based structural equation modelling (CV-SEM).FindingsThe results of this research confirmed that mindfulness and internal listening positively affect employee perceptions towards internal communication during a crisis. Similarly, ICC positively influences employees' perception of loyalty, job insecurity and the organisation's reputation. The results also highlight the moderation roles of emotional exhaustion (EE).Practical implicationsThe study suggests that applying ICC strategies will help crisis managers develop collaborative relationships with employees, which will help in identifying and managing a crisis. In addition, implementing effective internal communication in corporate practices and processes makes internal reputation and employee loyalty (EL) a reality and allows organisations to remain productive despite crises.Originality/valueThrough the lens of sensemaking theory, this research demonstrated that mindfulness and listening should be considered stimuli in organisations that can influence employees to be active communicators before and during crises. This study is the first to elucidate the essential outcomes for strategic internal crisis management that are often under-looked, such as emotional responses. The study also shows that sensemaking should not only focus on meaning-making in a crisis but also include emotional feelings that can wear out the meaning-making process.
The asymmetric effects of real variables on real housing prices: a nonlinear ARDL analysis for Turkey
Authors: Akpolat Ahmet Gökçe 
Published: November 2022

Purpose
This study aims to examine the impact of some real variables such as real effective exchange rates, real mortgage rates, real money supply, real construction cost index and housing sales on the real housing prices.

Design/methodology/approach
This study uses a nonlinear autoregressive distributed lag (NARDL) model in the monthly period of 2010:1–2021:10.

Findings
The real effective exchange rate has a positive and symmetric effect. The decreasing effect of negative changes in real money supply on real housing prices is higher than the increasing effect of positive changes. Only positive changes in the real construction cost index have an increasing and statistically significant effect on real house prices, while only negative changes in housing sales have a small negative sign and a small increasing effect on housing prices. The fact that the positive and negative changes in real mortgage rates are negative and positive, respectively, indicates that both have a reducing effect on real housing prices.

Originality/value
This study suggests the first NARDL model that investigates the asymmetric effects on real housing prices instead of nominal housing prices for Turkey. In addition, the study is the first, to the best of the authors’ knowledge, to examine the effects of the five real variables on real housing prices.
Making a virtue of necessity once again: assessing the effect of temporary labor on lean practices in highly routinized environments
Authors: López-Manuel Lucas , Sartal Antonio , Vázquez Xosé H. 
Published: November 2022

Purpose
The purpose of this paper is to evaluate how temporary labor moderates the relation between two well-known lean initiatives (process flow and process quality) and line productivity. This paper focuses on high-volume, low-variety (HVLV) shop floors, where work experience may not be as relevant as expected and extrinsic motivation of the temporary workforce could become a key driver of individual performance.

Design/methodology/approach
The authors follow an insider econometrics approach based on panel microdata (1,793 observations) from nine lines over two years in a Spanish manufacturing plant. The authors selected this setting for two reasons: Spain has traditionally had one of the highest levels of temporary employment in the world, so it perfectly represents labor market trends in OECD countries. Simultaneously, the authors also searched for a type of shop floor that could be representative of one of the most common manufacturing environments: a shop floor with highly repetitive and low-complexity work tasks.

Findings
The results of this paper suggest that in HVLV environments, temporary labor could contribute up to a 1.4% improvement in line productivity, provided there is a strong lean implementation. Otherwise, the use of temporary labor could undermine the positive effects of both process flow and process quality on plant productivity.

Originality/value
External incentives derived from high levels of unemployment, coupled with manufacturing’s increasing automation and specialization, may be minimizing the weaknesses traditionally associated with temporary workers in lean environments. By contrast, those shop floors lacking lean standards face serious productivity consequences from adjusting to global trends by using temporary work.
Accountants and small businesses: toward a resource-based view
Authors: Weigel Christine , Hiebl Martin R.W. 
Published: November 2022

Purpose
Small- and medium-sized enterprises (SMEs) carry huge economic importance worldwide. At the same time, SMEs face specific challenges, some of which may be alleviated by employing accountants. However, research on the role and impact of accountants in SMEs has long remained fragmented and scarce. This paper aims to encourage more research on accountants in SMEs by providing the first comprehensive and systematic review of relevant research.

Design/methodology/approach
Based on systematic review methods, the authors critically examine 68 research articles dealing with accountants in SMEs.

Findings
The review identifies three dominant roles for accountants in SMEs: providers of reporting services, sources of SME owners’ self-validation and translators between capital providers and SMEs and advisors. Implicitly, many studies assume a value-enhancing effect of employing accountants in SMEs regardless of these specific roles. At the same time, available studies seldom make use of existing theoretical frameworks to more closely analyze the value-enhancing potential of human resources such as accountants. The authors, thus, propose the resource-based view as a robust theoretical framework to improve theory building in research on accountants in SMEs.

Originality/value
To the best of the authors’ knowledge, this paper is the first systematic review of accountants in SMEs. In addition, the authors develop a resource-based model on accountants in SMEs to guide future research on this topic.
Family firms and international equity-based entry modes: a systematic literature review
Authors: Maggi Barbara , Pongelli Claudia , Sciascia Salvatore 
Published: November 2022

Purpose
Although research on family firms (FF) internationalization has seen a boom over the past 30 years, the understanding of how FFs internationalize with equity modes is still fragmented. Indeed, the majority of extant literature on this topic identifies internationalization with export, overlooking the alternative equity-based entry modes FFs have when entering a foreign country. The purpose of this paper is to fill this gap with a framework-based systematic literature review on the topic to improve the understanding of this phenomenon and propose a way forward.

Design/methodology/approach
This study conducted a framework-based systematic literature review of 93 papers published between 1993 and 2021.

Findings
This study adds to the current debate on FFs internationalization by integrating previous review efforts with a deeper investigation of FFs’ equity-based entry modes. This study contributes to this body of knowledge in the family business research by synthetizing and systematizing extant literature with a framework-based approach from the international business (IB) field. In so doing, this study builds a stronger link between these two areas of research. Finally, research gaps and promising research avenues for future studies are also presented.

Originality/value
This study responds to the call to create a dialogue between the FFs and IB fields by systematizing the extant body of knowledge and integrating the FF literature with one of the most widely used frameworks (Pan and Tse, 2000) on entry modes in the IB domain.
“I am doing my part, you are doing your part”: the sworn-civilian divide in police dispatching
Authors: Orosco Carlena , Gaub Janne E. 
Published: November 2022

PurposeWhile police culture typically refers to the culture among sworn police personnel, there are internal cultural differences between subgroups. This has been documented among sworn personnel, such as the difference between street cops and management cops (Reuss-Ianni, 1983). The divide between professional and sworn staff in a law enforcement context has also been discussed at length (Maguire, 1997; Reiss, 1992), specifically the “us versus them” mentality that stems from feelings of isolation among professional and sworn staff. The relationship between dispatchers and officers is vital to public and officer safety; it is imperative that cultural barriers preventing effective collaboration between two of the most critical components of policing are identified, and recommendations to bridge the gap are provided.Design/methodology/approachThe authors use semi-structured interview data from a sample of peer-nominated top dispatch de-escalators (TDDs) considered highly skilled at de-escalation with callers and officers. Reflexive coding techniques were used to identify key themes in an area largely unexamined by research.FindingsThe authors find that the police culture creates friction between sworn officers and dispatchers in a number of contexts. This diminishes organizational commitment and increases burnout and frustration.Practical implicationsThere are several policy recommendations for both communications centers and sworn staff to foster understanding and increase collaboration, all of which may result in improved outcomes for community members, dispatchers and officers.Originality/valueThe authors use qualitative methods to explore the implications of the sworn-civilian divide for police practice, such as more effective de-escalation and incident resolution, as well as the conceptualization of police culture writ large.
Perceptions of police use of surveillance cameras in Ghana; does procedural justice matter?
Authors: Hevi Stewart Selase , Malcalm Ebenezer , Ketemepi Gifty Enyonam , Wuttor Akorfa , Agbenorxevi Clemence Dupey 
Published: November 2022

Purpose
This paper aims to investigate the effect of perception of police use of surveillance cameras (POP-S), perception of police legitimacy (POP-L) and community well-being. The study further explores the mediating effect of procedural justice between POP-S and police legitimacy.

Design/methodology/approach
A convenience sampling technique was used in the selection of 388 participants, who answered questions relating to police use of surveillance cameras, legitimacy, procedural justice and community well-being. Structural equation modeling was used to test the effects of the hypothesized paths.

Findings
The findings showed that POP-L was positively related to community well-being. In addition, procedural fairness partially mediates between POP-S and police legitimacy.

Research limitations/implications
The study sample was limited to only motorists within the city of Accra. Hence, the study does not consider other potential offenses that may be uncovered by police-deployed surveillance cameras.

Practical implications
The study optimizes the relevance of technology use in contemporary policing for the elimination of road traffic carnage.

Originality/value
In this research, the academic scope of technology-based policing was scholarly advanced by drawing links between police use of surveillance cameras, police legitimacy, procedural justice and community well-being within the context of emerging economies.