bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary orbital atherectomy treatment of Hispanic and Latino patients: A real‐world comparative analysis
Authors: Beohar Nirat , Stone Gregg W. , Martinsen Brad J. , Parise Helen , Vinardell Juan M. , Heimowitz Todd , Koelbl Christian , Leon Martin B. , Kirtane Ajay J. 
Published: March 2022

AbstractObjectivesTo assess coronary orbital atherectomy (OA) use in Hispanic or Latino (HL) patients compared to non‐HL patients.BackgroundHL patients are at greater risk of cardiovascular disease mortality compared with Whites with similar coronary artery calcium (CAC) scores. The safety and efficacy of coronary atherectomy in the HL patient population is unknown due to the under‐representation of minorities in clinical trial research.MethodsA retrospective analysis of consecutive patients undergoing coronary OA treatment of severely calcified lesions at the Mount Sinai Medical Center, Miami Beach, Florida (MSMCMB) was completed. From January 2014 to September 2020, a total of 609 patients from MSMCMB who underwent percutaneous coronary intervention with OA were identified in the electronic health records.ResultsOf those identified, 350 (57.5%) had an ethnicity classification of HL. The overall mean age was 74 years and there was a high prevalence of diabetes in the HL group compared to the non‐HL group (49.7% vs. 34.7%; p = 0.0003). Severe angiographic complications were uncommon and in‐hospital freedom from major adverse cardiac events (MACE), a composite of cardiac death, MI, and stroke (ischemic or hemorrhagic cerebrovascular accidents), was 98.5% overall, with no significant difference between the HL and non‐HL groups, despite the higher prevalence of diabetes in the HL group.ConclusionsThis study represents the largest real‐world experience of OA use in HL versus non‐HL patients. The main finding in this retrospective analysis is that OA can be performed safely and effectively in a high‐risk population of HL patients.
Early and late outcomes of surgical aortic valve replacement with sutureless and rapid‐deployment valves versus transcatheter aortic valve implantation: Meta‐analysis with reconstructed time‐to‐event data of matched studies
Authors: Sá Michel Pompeu , Jabagi Habib , Dokollari Aleksander , Awad Ahmed K. , Van den Eynde Jef , Malin John H. , Sicouri Serge , Torregrossa Gianluca , Ruhparwar Arjang , Weymann Alexander , Ramlawi Basel 
Published: March 2022

AbstractSutureless/rapid‐deployment (SURD) valves are options different from the stented prostheses included in the pivotal trials comparing surgical aortic valve replacement (AVR) and transcatheter aortic valve implantation (TAVI). We performed a meta‐analysis with reconstructed time‐to‐event data of matched studies published by November 2021 to compare SURD‐AVR and TAVI. Primary endpoints were 30‐day mortality and overall survival in the follow‐up. Secondary endpoints included: 30‐day stroke, acute kidney injury (AKI), major bleeding, permanent pacemaker implantation (PPI), paravalvular leak (PVL), prosthesis‐patient mismatch (PPM), postoperative aortic valve area (AVA), and mean gradients. Ten studies met our eligibility criteria, including a total of 5134 patients (2567 underwent SURD‐AVR and 2567 underwent TAVI). Pooled risk of 30‐day mortality did not favor any group (odds ratio [OR]: 0.69; 95% confidence interval [CI]: 0.31–1.53; p = 0.360). Patients undergoing SURD‐AVR had lower risk of PVL (OR: 0.09; 95% CI: 0.05–0.17; p < 0.001). No statistically significant differences were observed for 30‐day stroke, AKI, major bleeding, PPI, PPM, and postoperative AVA. In the follow‐up, we observed a higher risk of mortality (hazard ratio: 1.74; 95% CI: 1.26–2.40; p < 0.001) with TAVI. Patients who underwent SURD‐AVR experienced better survival, however, the interpretation of these results warrant caution due to the fact that SURD‐AVR patients tended to be younger than TAVI patients. Structural heart surgeons and interventional cardiologists should consider initial risk and life expectancy when referring patients for one approach over the other.
Effect of high‐pressure CO2 injection on the physicochemical properties and lipoxygenase activity of extruded rice bran
Authors: Gao Yuxuan , Zhang Yu , Jin Tie 
Published: March 2022

AbstractBackground and ObjectivesRice bran is rich in nutrients but not very stable and available, so extrusion of it broadens its utilization value. The objective was to investigate the effects of extrusion parameter variables on the physicochemical properties and lipoxygenase activity of extruded rice bran. The extrusion parameter variables were set as extrusion temperature (80, 90, 110, 140°C); CO2 injection, and no CO2 injection; screw speed (200, 300 rpm).FindingsCO2 injection significantly affected the expansion characteristics and lipoxygenase activity of extruded rice bran. It better inhibits lipoxygenase activity and at a fixed screw speed of 200 rpm, the bulk density of extruded rice bran with CO2 injection was higher than that of conventional extrusion. After extrusion, the soluble dietary fiber content was significantly increased in the extruded samples compared with the raw material. In contrast, the content of dietary fiber was not significantly affected by CO2 injection.ConclusionsCompared with the conventional extrusion method, the CO2‐injected extrusion has significant effects on the expansion characteristics and nutritional composition. Extrusion with CO2 injection can reduce lipoxygenase activity more effectively.Significance and NoveltyThe results prove that CO2 extrusion can inhibit the lipoxygenase activity, and change the physicochemical properties of rice bran compared with conventional extrusion. It provides a basis for the application of CO2 as a medium in extruded rice bran food and a new process for processing rice bran by‐products.
Effect of pulsed light treatment on the physicochemical properties of wheat flour and quality of fresh wet noodles
Authors: Li Xuejie , Zhang Jian , Liu Xingli , Zhang Jie , Qu Niannian , Wen Yaqing 
Published: March 2022

AbstractBackground and ObjectivesPulsed light (PL) was first applied to the production of low bacterial wheat flour—treating wheat kernels with PL. The effect of PL on the physicochemical properties of wheat flour and the quality of fresh wet noodles (FWN) were investigated.FindingsAfter treatment, the total plate count (TPC), yeast and mold count (YMC) in wheat flour decreased significantly. Wet gluten content and the stability time reached their maximums when the pulsed flash frequency was 10 c. Starch viscosity increased slightly, mainly due to an increase in damaged starch content. Secondary structures altered remarkably, which were consistent with changes in gluten protein microstructures. Moreover, the textural properties of FWN were improved greatly. Browning of FWN was significantly inhibited because of low polyphenol oxidase (PPO) activity in wheat flour.ConclusionPL was effective in decreasing the initial microorganisms in wheat flour as well as improving the quality of dough and FWN, and the optimum treatment was pulsed energy of 500 J, pulsed flash distance of 9 cm, and pulsed frequency of 10 c.Significance and NoveltyThese results showed that PL treatment could decrease TPC and YMC in wheat flour significantly, improve farinograph and pasting properties, change gluten protein microstructures and secondary structures, as well as improve textural properties of FWN and inhibit its darkening greatly, which provided a new method for low bacterial wheat flour production and promoted PL's industrialization.
Well‐defined Nickel P3C Complexes as Hydrogenation Catalysts of N‐Heteroarenes Under Mild Conditions
Authors: Michaliszyn Klaudia , Smirnova Ekaterina S. , Bucci Alberto , Martin‐Diaconescu Vlad , Lloret Fillol Julio 
Published: March 2022

AbstractThe reactivity of metal complexes can be primarily controlled by their coordinating ligands. Electronic effects and geometric restrictions imposed by ligands, prototypically modify their reactivity, but are not always straightforward accessible. In the course of the study, we explored new C3‐symmetric organometallic nickel (II) complexes ((P3C)Ni)) with the particularity of having a metalated apical carbon trans to a labile coordination site readily available as a catalytic site. The synthetic methodology allowed to tune the electronic properties by introducing substituents on the phosphines. We studied the nature of the C−Ni bond by X‐ray absorption spectroscopy (XAS) and DFT and applied them to the catalytic hydrogenation of quinolines with a good chemical scope and group tolerance. 1H‐NMR monitoring, isotopic labelling, and computational studies are consistent with a heterolytic activation of the dihydrogen molecule after forming a σ‐H2 adduct trans to the metalated carbon.
Reuse Potential of Refinery Wastewater Treated Using a Two‐Stage Submerged Membrane Bioreactor
Authors: Paul Tanushree , Janakiraman Iyyappan , Manikandan N. Arul , Pakshirajan Kannan , Pugazhenthi Gopal , Girisa Sosmitha , Kunnumakkara Ajaikumar B. 
Published: March 2022

AbstractRefinery wastewater treatment was performed using a novel submerged tubular ceramic membrane bioreactor (STMBR) with the oleaginous hydrocarbonoclastic bacterium Rhodococcus opacus. A membrane‐based flux study with the STMBR was carried out to assess the performance of the tubular ceramic membrane. Continuous experiments with the STMBR achieved a maximum chemical oxygen demand (COD) removal of 84 %, with an average flux of 0.4 × 10−3 m3m−2s−1. To further enhance the COD removal efficiency, two STMBR were operated under the optimum conditions. Complete COD removal along with 2.98 g L−1 biomass growth was achieved during two‐stage STMBR operation. Furthermore, a toxicity assessment of the permeate water established its reuse potential.
Deciphering the lithium storage chemistry in flexible carbon fiber‐based self‐supportive electrodes
Authors: Yang Hao , Xiong Tuzhi , Zhu Zhixiao , Xiao Ran , Yao Xincheng , Huang Yongchao , Balogun M.‐Sadeeq 
Published: March 2022

AbstractFlexible carbon fiber cloth (CFC) is an important scaffold and/or current collector for active materials in the development of flexible self‐supportive electrode materials (SSEMs), especially in lithium‐ion batteries. However, during the intercalation of Li ions into the matrix of CFC (below 0.5 V vs. Li/Li+), the incompatibility in the capacity of the CFC, when used directly as an anode material or as a current collector for active materials, leads to difficulty in the estimation of its actual contribution. To address this issue, we prepared Ni5P4 nanosheets on CFC (denoted CFC@Ni5P4) and investigated the contribution of CFC in the CFC@Ni5P4 by comparing to the powder Ni5P4 nanosheets traditionally coated on a copper foil (CuF) (denoted P‐Ni5P4). At a current density of 0.4 mA cm−2, the as‐prepared CFC@Ni5P4 showed an areal capacity of 7.38 mAh cm−2, which is significantly higher than that of the P‐Ni5P4 electrode. More importantly, theoretical studies revealed that the CFC has a high Li adsorption energy that contributes to the low Li‐ion diffusion energy barrier of the Ni5P4 due to the strong interaction between the CFC and Ni5P4, leading to the superior Li‐ion storage performance of the CFC@Ni5P4 over the pristine Ni5P4 sample. This present work unveils the underlying mechanism leading to the achievement of high performance in SSEMs.
Acenaphthenoannulation Induced by the Dual Lewis Acidity of Alumina
Authors: Akhmetov Vladimir , Feofanov Mikhail , Ruppenstein Cordula , Lange Josefine , Sharapa Dmitry , Krstić Marjan , Hampel Frank , Kataev Evgeny A. , Amsharov Konstantin 
Published: March 2022

AbstractWe have discovered a dual (i. e., soft and hard) Lewis acidity of alumina that enables rapid one‐pot π‐extension through the activation of terminal alkynes followed by C−F activation. The tandem reaction introduces an acenaphthene fragment – an essential moiety of geodesic polyarenes. This reaction provides quick access to elusive non‐alternant polyarenes such as π‐extended buckybowls and helicenes through three‐point annulation of the 1‐(2‐ethynyl‐6‐fluorophenyl)naphthalene moiety. The versatility of the developed method was demonstrated by the synthesis of unprecedented structural fragments of elusive geodesic graphene nanoribbons.
Post‐PCI quantitative flow ratio predicts 3‐year outcome after rotational atherectomy in patients with heavily calcified lesions
Authors: You Wei , Zhou Yuhe , Wu Zhiming , Meng Peina , Pan Defeng , Yin Delu , Yang Song , Wu Xiangqi , Ye Fei 
Published: March 2022

AbstractBackgroundThe study sought to investigate the clinical predictive value of quantitative flow ratio (QFR) for the long‐term outcome in patients with heavily calcified lesions who underwent percutaneous coronary intervention (PCI) following rotational atherectomy (RA).MethodsIn this retrospective study, 393 consecutive patients from 2009 to 2017 were enrolled. The QFR of the entire target vessel (QFRv) and the QFR of the stent plus 5 mm proximally and distally (in‐segment) (QFRi) were measured. The primary endpoint was target lesion failure (TLF), including target lesion‐cardiac death (TL‐CD), target lesion‐myocardial infarction (TL‐MI), and clinically driven‐target lesion revascularization (CD‐TLR).ResultsA total of 224 patients with 224 calcified lesions completed the clinical follow‐up, and 52 patients had TLF. There was no significant difference in QFRv post‐PCI between non‐TLF and TLF groups (p > .05). However, QFRi post PCI was significantly higher in the non‐TLF group than in the TLF group. Multivariate Cox regression showed that QFRi post‐PCI was an excellent predictor of TLF after a 3‐year follow‐up (HR 1.7E−8 [5.3E−11–5.6E‐6]; p < .01). Furthermore, receiver‐operating characteristic curve analysis demonstrated that the optimal cutoff value of QFRi for predicting the long‐term TLF was 0.94 (area under the curve: 0.826, 95% confidence interval: 0.756–0.895; sensitivity: 89.5%, specificity: 69.2%; p < .01). The QFRi ≤ 0.94 post‐PCI was negatively associated with TLF, including TL‐CD, TL‐MI, and CD‐TLR (p < .01).ConclusionsQFRi post‐PCI showed a high predictive value for TLF for during a 3‐year follow‐up in patients who underwent PCI following RA; specifically, lower QFRi values post‐PCI were associated with worse TLF.
A Green Synthesis of Carbene‐Metal‐Amides (CMAs) and Carboline‐Derived CMAs with Potentin vitroandex vivoAnticancer Activity
Authors: Tzouras Nikolaos V. , Scattolin Thomas , Gobbo Alberto , Bhandary Subhrajyoti , Rizzolio Flavio , Cavarzerani Enrico , Canzonieri Vincenzo , Van Hecke Kristof , Vougioukalakis Georgios C. , Cazin Catherine S. J. , Nolan Steven P. 
Published: March 2022

AbstractThe modularity and ease of synthesis of carbene‐metal‐amide (CMA) complexes based on the coinage metals (Au, Ag, Cu) and N‐heterocyclic carbenes (NHCs) as ancillary ligands pave the way for the expansion of their applications beyond photochemistry and catalysis. Herein, we further improve the synthesis of such compounds by circumventing the use of toxic organic solvents which were previously required for their purification, and we expand their scope to include complexes incorporating carbolines as the amido fragments. The novel complexes are screened bothin vitroandex vivo, against several cancer cell lines and high‐grade serous ovarian cancer (HGSOC) tumoroids, respectively. Excellent cytotoxicity values are obtained for most complexes, while the structural variety of the CMA library screened thus far, provides promising leads for future developments. Variations of all three components (NHC, metal, amido ligand), enable the establishment of trends regarding cytotoxicity and selectivity towards cancerous over normal cells.
Uniqueness of Two‐Bubble Wave Maps in High Equivariance Classes
Authors: Jendrej Jacek , Lawrie Andrew 
Published: March 2022

AbstractThis is the second part of a two‐paper series that establishes the uniqueness and regularity of a threshold energy wave map that does not scatter in both time directions.Consider the ‐valued equivariant energy critical wave maps equation on , with equivariance class . It is known that every topologically trivial wave map with energy less than twice that of the unique k‐equivariant harmonic map scatters in both time directions. We study maps with precisely the threshold energy .In the first part of the series [15] we gave a refined construction of a threshold wave map that asymptotically decouples into a superposition of two harmonic maps (bubbles), one of which is concentrating in scale. In this paper, we show that this solution is the unique (up to the natural invariances of the equation) two‐bubble wave map. Combined with our earlier work [14] we obtain an exact description of every threshold wave map. © 2022 The Authors. Communications on Pure and Applied Mathematics published by Wiley Periodicals LLC.
Comparison of porcelain veneer fracture in implant‐supported fixed full‐arch prostheses with a framework of either titanium, cobalt–chromium, or zirconia: An in vitro study
Authors: Vahnström Märta , Johansson Petra H. , Svanborg Per , Stenport Victoria F. 
Published: March 2022

AbstractObjectivesThe aim of this study was to compare porcelain veneer strength on screw‐retained implant‐supported fixed full‐arch prostheses with a framework of either milled titanium (Ti), cobalt–chromium (CoCr), and yttria‐stabilized zirconia (Y‐TZP) in an in vitro loading model.Materials and MethodsFifteen screw‐retained maxillary implant‐supported full‐arch prostheses (FDP), five each of Ti, CoCr, and Y‐TZP frameworks with porcelain veneers were included. All FDPs were subjected to thermocycling before loading until fracture of the veneer. The load was applied at the distal fossa of the occlusal area of the pontic replacing 24. Fracture loads were analyzed, and the fracture quality was assessed. Statistical analysis on the fracture load was performed using Kruskal–Wallis test. The statistical significance was set at p < .05.ResultsThere was no statistical significance found between the groups regarding fracture load. The highest and lowest load was seen within the CoCr FDP, varying between 340 and 1484 N. Different types of fracture appearances were seen. The Y‐TZP FDPs had a higher number of fractures locally in the loaded area while CoCr and Ti more often showed cracks in the anterior region, at a distance from the loaded area.ConclusionsWithin the limitations of this study, the conclusion was that framework material may affect the fracture behavior of maxillary full‐arch bridges; however, there were no differences in veneer fracture strength when frameworks of Ti, CoCr, or Y‐TZP were compared.
Specificity of California mouse pup vocalizations in response to olfactory stimuli
Authors: Wilson Kerianne M. , Wagner Victoria A. , Saltzman Wendy 
Published: March 2022

AbstractTo investigate flexibility in vocal signaling by rodent pups, we examined whether olfactory stimuli influence characteristics of pup calls and how these calls may be affected by sex and litter size in California mice (Peromyscus californicus). Pups were isolated and recorded during a 3‐min baseline period followed by a 5‐min exposure to bedding containing scent from their home cage, scent from the home cage of an unfamiliar family, coyote urine, or no scent (control). Latency to call, call rate, and call characteristics (duration, frequency, and amplitude) were compared between the baseline and scent‐exposure periods and among olfactory conditions. Compared with the control condition, pups from two‐pup litters called more quietly when exposed to odor from a predator, whereas pups from three‐pup litters called more loudly. Additionally, pups showed nonsignificant tendencies to reduce call rates in response to odors from their home cage and to increase call rates when exposed to predator urine. Last, males produced higher‐frequency calls and more ultrasonic vocalizations than females. These results indicate that pup calling behavior in this species can be influenced by acute olfactory stimuli as well as litter size and sex. The flexibility of pup calling in response to these three variables potentially increases the communication value of pup calls and helps shape the parents’ responses.
Disturbance alters relationships between soil carbon pools and aboveground vegetation attributes in an anthropogenic peatland in Patagonia
Authors: Lopatin Javier , Araya‐López Rocío , Galleguillos Mauricio , Perez‐Quezada Jorge F. 
Published: March 2022

AbstractAnthropogenic‐based disturbances may alter peatland soil–plant causal associations and their ability to sequester carbon. Likewise, it is unclear how the vegetation attributes are linked with different soil C decomposition‐based pools (i.e., live moss, debris, and poorly‐ to highly‐decomposed peat) under grassing and harvesting conditions. Therefore, we aimed to assess the relationships between aboveground vegetation attributes and belowground C pools in a Northern Patagonian peatland of Sphagnum magellanicum with disturbed and undisturbed areas. We used ordination to depict the main C pool and floristic gradients and structural equation modeling (SEM) to explore the direct and indirect relationships among these variables. In addition, we evaluated whether attributes derived from plant functional types (PFTs) are better suited to predict soil C pools than attributes derived from species gradients. We found that the floristic composition of the peatland can be classified into three categories that follow the C pool gradient. These categories correspond to (1) woody species, such as Baccharis patagonica, (2) water‐logged species like Juncus procerus, and (3) grasslands. We depicted that these classes are reliable indicators of soil C decomposition stages. However, the relationships change between management. We found a clear statistical trend showing a decrease of live moss, debris, and poorly‐decomposed C pools in the disturbed area. We also depicted that plant diversity, plant height, and PFT composition were reliable indicators of C decomposition only under undisturbed conditions, while the species‐based attributes consistently yielded better overall results predicting soil C pools than PFT‐based attributes. Our results imply that managed peatlands of Northern Patagonia with active grassing and harvesting activities, even if small‐scaled, will significantly alter their future C sequestration capacities by decreasing their live and poorly‐decomposed components. Finally, aboveground vegetation attributes cannot be used as proxies of soil C decomposition in disturbed peatlands as they no longer relate to decomposition stages.