bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge of necrophagous insects by justice actors and traditional gravediggers for their application in criminal investigations in the northern and southern Sudanese zones of Burkina Faso
Authors: Zongo David , Drabo Samuel Fogné , Séré Aminata , Romba Rahim , Bougma Adjima , Millogo Missa , Salou Noufou , Zeba Moctar , Kinda Prosper , GNANKINE Olivier 
Published: July 2022

Abstract
Forensic entomology is used in criminal investigations for post-mortem dating of cadavers. The aims of this study was to evaluate the endogenous knowledge of necrophagous insects of six target groups of workers in two climatic zones of Burkina Faso for their application in criminal investigations. The survey was conducted among 223 informants splited in six target groups in four cities and eight villages belonging to Sudano-Sahelian and Sudanian climatic zones. The study was conducted on the knowledge of necrophagous insects from exhumed and exposed corpses to the air. Chi-square tests and principal component analysis (PCA) were performed to check for species diversity distributions significant differences in knowledge and climatic zones of study. The different phases of insect succession on post-mortem corpses were cited. The results showed that knowledge of the species varies from one species to another. The most cited species are Calliphoridae larvae and pupae with a frequency of citation of 16.54% for open corpses Astrapaeus sp. with a frequency of citation of 32.25% for exhumed corpses. The citation of species also varied according to locality climatic zone and function of the informants. Traditional gravediggers and funeral workers cited more species than other justice actors. The species of Chrysomya sp. and Lucilia sp. are species found to be specific to the West African area and were mentioned for the first time in Burkina Faso. The knowledge of necrophagous insects by the informants in this survey opens new perspectives for entomological expertise in criminal investigations in Burkina Faso.
Design of inherent fire retarding and degradable bio-based epoxy vitrimer with excellent self-healing and mechanical reprocessability
Authors: Yang Weijun , Ding Hui , Zhou Wei , Liu Tianxi , Xu Pengwu , Puglia Debora , Kenny Jose M , Ma Piming 
Published: July 2022

Abstract
Epoxy resin possesses poor flame retardancy and difficulty in both recycling and reprocess ability that largely limit its application. Herein, two vanillin based epoxy monomers, shorted as VAD-EP (A) and VDP-EP (P), containing both imine bonds and inherently fire retarding phosphorus elements, were synthesized via in situ condensation reaction with DDM and addition reaction with DOPO, followed by the epoxidation by epichlorohydrin. Epoxy vitrimer materials were then cured by D230 diamine hardener by adjusting the proportion of VAD-EP and VDP-EP monomer. When the mass ratio of VAD-EP and VDP-EP was 8:2, A8P2-D230 reached the fire retarding UL-94 V0 rating and LOI value of 27.0% with only 0.66% of phosphorus content, this behavior was ascribed to condensed phase and free radical scavenging mechanisms. When the mass ratio was 7:3, the tensile strength and elastic modulus of the A7P3-D230 epoxy were 75.5 MPa and 2.5 GPa, respectively, i.e. 48.6% and 18.8% higher than A10P0-D230 sample. Meanwhile, the material showed high stress relaxation rate, due to the presence of dynamic imine bonds in the topological crosslinking network. As a consequence, the epoxy vitrimer exhibited excellent self-healing capability, reprocessability and degradation behaviors. The biobased epoxy vitrimer was then used to prepare the carbon fibers (CFs) reinforced epoxy composites, results showed that CFs can be completely recycled. Interestingly, the recycled CFs maintain unchanged chemical structure, mechanical properties and morphology as the original CFs.
Effectiveness of laparoscopic tubal anastomosis in tubal ligation patients, A retrospective study
Authors: Ding Nan , zhang Jian , Wang peili , Wang Fang 
Published: July 2022

Abstract
Objective
To evaluate the pregnancy outcome after laparoscopic tubal anastomosis and to analyze the factors that may affect the pregnancy outcome.
Methods
This study was a retrospective analysis of pregnancy outcomes in 82 patients with a history of tubal sterilization treated with laparoscopic tubal anastomosis at the Lanzhou University Second Hospital Reproductive Medicine from July 2017 to December 2021. The primary outcomes were intrauterine pregnancy, ectopic pregnancy, miscarriage. We also examined relevant factors that may influence pregnancy status.
Results
The cumulative clinical pregnancy rate for all patients was 52/81 (63.61%). The distribution of pregnancy outcomes for the whole group was as follows: intrauterine pregnancy rate, 49/81 (59.75%), ectopic pregnancy rate, 3/82 (3.66%) and miscarriage rate, 5/81 (6.10%). In the multivariate model, age, pelvic adhesions, and endometrial polyps may be the main prognostic factors.
Conclusion
Laparoscopic tubal anastomosis is an effective treatment for patients with tubal-related infertility, especially for women under 40 years.
Enabling Data-Limited Chemical Bioactivity Predictions through Deep Neural Network Transfer Learning
Authors: Liu Ruifeng , Laxminarayan Srinivas , Reifman Jaques , Wallqvist Anders 
Published: July 2022

Abstract
The main limitation in developing deep neural network (DNN) models to predict bioactivity properties of chemicals is the lack of sufficient assay data to train the network’s classification layers. Focusing on feedforward DNNs that use atom- and bond-based structural fingerprints as input, we examined whether layers of a fully trained DNN based on large amounts of data to predict one property could be used to develop DNNs to predict other related or unrelated properties based on limited amounts of data. Hence, we assessed if and under what conditions the dense layers of a pre-trained DNN could be transferred and used for the development of another DNN associated with limited training data. We carried out a quantitative study employing more than 400 pairs of assay datasets, where we used fully trained layers from a large dataset to augment the training of a small dataset. We found that the higher the correlation r between two assay datasets, the more efficient the transfer learning is in reducing prediction errors associated with the smaller dataset DNN predictions. The reduction in mean squared prediction errors ranged from 10–20% for every 0.1 increase in r2 between the datasets, with the bulk of the error reductions associated with transfers of the first dense layer. Transfer of other dense layers did not result in additional benefits, suggesting that deeper, dense layers conveyed more specialized and assay-specific information. Importantly, depending on the dataset correlation, training sample size could be reduced by up to 10-fold without any loss of prediction accuracy.
Single irrigation at the four-leaf stage in the spring optimizes winter wheat water consumption characteristics and water use efficiency
Authors: Bao Xiaoyuan , Liu Xuejing , Hou Xiaoyang , Yin Baozhong , Duan Weiwei , Wang Yandong , Ren Jianhong , Gu Limin , Zhen Wenchao 
Published: July 2022

Abstract
Water scarcity is a major limiting factor for crop production in North China Plain (NCP), which produces the majority of the country's winter wheat (Triticum aestivum L.). The objective of this three-year field study was to see if and when irrigation one-time in spring improves grain yield and water use efficiency. Four sets of irrigation were established at the 3-leaf visible stage (L3) and the L4, L5, and L6 stages. The spike number, 1,000-grain weight, and water consumption increased progressively when irrigation time was delayed, whereas grain yield, grain number, dry matter, harvest, and WUE grew, then dropped, and peaked at L4. The increased grain number can be attributed to the L4's higher daily water consumption and water consumption percentage than the L3, L5, and L6 at the jointing-anthesis stages. L4 had a shorter cumulative period of soil drought stress (37 days), whereas L3, L5, and L6 had 40, 42, and 43 days, respectively. Furthermore, flag leaf senescence was postponed in L4 with a better post-anthesis leaf area index, photosynthetic rate, chlorophyll content, stronger superoxide dismutase activity, and reduced malondialdehyde concentration. As a result, single irrigation at the 4-leaf visible stage optimized water deficit and consumption before and after anthesis, resulting in higher yield and WUE in the NCP.
The influence of extremely high body weight (BMI &gt; 35kg/ m2) on apixaban plasma concentration in patients with atrial fibrillation
Authors: Hilu May , Colodner Raul , Eitam Harel , Avraham Gilat Ron , Ram Kerstin Carlin , Elias Mazen , Shimoni Orli , Schwartzberg Eyal , Goldstein Lee Hilary 
Published: July 2022

Abstract
Apixaban, a direct oral anticoagulant (DOAC) is administered in a fixed-dose regimen for atrial fibrillation patients. Dosage adjustment is based on renal function, age, and body weight (less than 60 kg). No data exist on the pharmacokinetics of apixaban in patients with body mass index (BMI) ≥ 35 Kg/m2, nor about treatment efficacy and safety in this population. Aims: To reveal whether BMI ≥ 35 kg/m2 affects trough plasma concentrations of apixaban in patients with atrial fibrillation and whether dose adjustment is required in this population. Methods: This prospective study compared steady state trough concentrations of apixaban in patients with BMI ≥ 35 kg/m2 and patients with BMI < 35 kg/m2. Results: Sixty patients were included in the study. In patients on 5 mg twice daily dose, the median trough plasma concentration was 29% lower in the high BMI group (BMI ≥ 35 kg/m2) compared with the lower BMI group (BMI < 35 kg/m2) (148.9 ng/ml, IQR: 94.5-205.6, compared to 209.1 ng/ml IQR: 167- 266.8 ng/ml respectively). P = 0.044. However, median trough concentrations were within the manufactures predicted steady-state apixaban exposure range. A similar trend was found among patients treated with 2.5 mg apixaban twice daily, but the results did not reach statistical significance. According to multivariate analysis performed, no correlation was found between BMI values (neither BMI ≥ 35 kg/m2 nor BMI < 35 kg/m2) and trough concentrations. Conclusion: Lower apixaban trough concentration was observed in patients with BMI ≥ 35 kg/m2 but remains within the steady-state apixaban exposure range found to be effective according to manufacturer data.
Testing the effects of perceptual grouping on visual search in older adults
Authors: Lai Sung-Nan , Jingling Li 
Published: July 2022

Abstract
Visual search is to find targets while ignoring distractors. Previous studies established that a target is more difficult to identify if aligned collinearly with other items, called the collinear search impairment. Since older adults have lower perceptual grouping ability than younger adults, benefits in visual search may occur for older adults for they may be less distracted by the collinear distractors. Three experiments were carried out to compare 45 younger and 45 older healthy adults. Participants were asked to identify a target either overlapping or non-overlapping with a collinear distractor, and the response difference between the two conditions is the collinear search impairment. Results showed that both groups showed reliable search impairment specific to collinear distractor regardless of grouping difficulty and task demands, and the impairment strength increased with the grouping strength of the collinear distractor. Further analysis revealed that the response times of older adults increased in a multiplicative manner to that of younger adults, suggesting that longer response of older adults spread to multiple underlying processing including grouping and suppression of collinear distractors. Together, the results suggest that older adults were still distracted in visual search even when grouping was required on a distractor. Our findings also highlight how general slowing may delay suppression processing in visual search.
oxLDL promotes EMS-induced angiogenesis by up-regulating VEGF-A expression and secretion of endometrial cells
Authors: Ma Caiqi , Huang Wei , Wang Hui , Yao Wenxia , Liang Min , Yu Guifang , Zhou Xinke 
Published: July 2022

Abstract
Background
Endometriosis (EMS) is a "tumor-like" gynecological disease with distant metastasis, and studies have shown that EMS can carry out distant metastasis through vascular vessels, but the driving factor and its mechanism is not clear.
Methods
We use EMS animal model and gene knockout technique to explore the role of EMS-induced angiogenesis in EMS metastasis in vivo and in vitro, and clarify the role and molecular mechanism of oxLDL in promoting EMS induced angiogenesis.
Results
We found that microvascular density (MVD) in metastasized ectopic endometrium and eutopic endometrial tissue were higher than the normal endometrial tissue, and the plasma oxLDL was positively correlated with the distant metastasis of EMS. Furthermore, we clarify that oxLDL enhanced the MVD of endometrial tissue by up-regulating the VEGF-A expression and secretion in endometrial cells. At last, we illustrated the mechanism of oxLDL promoting the VEGF-A expression through the AKT-HIF-1α signaling pathway.
Conclusion
oxLDL is a risk factor promoting the EMS distant metastasis by up-regulating VEGF-A expression and secretion through AKT-HIF-1α signaling. This founding may provide theoretical support and therapeutic targets for the clinical prevention and treatment of EMS.
Evaluation of a Pilot, Community-Led Mental Illness De-stigmatization Theater Intervention in Rural Uganda
Authors: Lee Yang Jae , Rauben Kazungu , Liu Curtis , Kim Rebecca , Velde Nina van der , Taylor Chelsea , Walsh Alyssa , Asasira Mildred , Katongole Ivan , Hatfield-King Jolee , Blackwell Scott , Iheanacho Theddeus , Christ Ryan , Ssekalo Ibrahim 
Published: July 2022

Abstract
Background
In rural areas of low- and middle- income countries (LMICs), mental health care is often unavailable and inaccessible, and stigma is a major barrier to treatment. Destigmatization can increase treatment-seeking attitudes, community support, and acceptance of mentally ill individuals. This study’s primary objective was to evaluate the impact of a community-led, theater-based destigmatization campaign for mental illness conducted in the Busoga region of Eastern Uganda.
Methods
One hundred residents of the Busoga region were randomly selected via cluster sampling to complete a structured questionnaire assessing mental health stigma. Common misconceptions and points of stigma were identified from these responses, and local village health team personnel (VHTs) developed and performed a culturally-adapted theatrical performance addressing these points. Changes in perceptions of mental illness were measured among 57 attendees using two measures, the Broad Acceptance Scale (BAS) and Personal Acceptance Scale (PAS), before and after the performance.
Results
There was a significant increase in acceptance according to the BAS (p < .001) and PAS (p < .001). Qualitative responses from play attendees also indicated a decrease in stigma and an increased sense of the importance of seeking treatment for mentally ill patients.
Conclusions
This study shows community-led, theater intervention may be an effective tool for the destigmatization of mental illness in rural areas of Uganda. Further, larger studies are needed to test its effectiveness, and potential for scale up and sustainment.
E-scooter Related Facial Injuries- A One Year Review Following Implementation Of A Citywide Trial
Authors: Sritha Rajeevan , Blore Christopher , Arya Richa , McMillan Kevin 
Published: July 2022

Abstract
ObjectiveBirmingham City Council commenced e-scooter trials from September 2020 as part of the wider UK effort to introduce E-scooters as an alternative method of transport. Our aim was to review and evaluate maxillofacial injuries in the initial trial period of 1-year and comment on the safety implications.MethodThe Queen Elizabeth Hospital is a level 1 Major Trauma Centre and the hub for maxillofacial services in Birmingham, UK. A single-center retrospective study captured patients who sustained e-scooter related facial injuries in the Birmingham e-scooter trial period from September 2020 to September 2021.ResultsA total of 29 patients were identified as having facial injuries. 59% (n=17) of patients were male and aged under 30. 43% (n=18) of all injuries recorded involved hard tissue. 41% (n=12) of patients were recorded to be under the influence of alcohol or cannabis. The non-use of helmets was recorded at 34% (n=10) of patients. 20 patients were managed operatively. 100% of patients (n=12) that were under the influence of drugs or alcohol required operative management.ConclusionWith the introduction of the trials, it is shown that facial injuries represent a sizeable proportion of all injuries. It is clear that e-scooters have significant safety issues. Our study may influence legislation to account for improvements in users’ compliance to safety measures and enforcement of those using e-scooters illegally. Legislation regarding the future of E-scooters is expected from the Department of Transport (UK) in March 2022.
Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Authors: Cherry Jared Michael , Kamel Serageldin , Elfil Mohamed , Aravala Sai Sudha , Bayoumi Ahmed , Patel Amar , Sinha Rajita , Tinaz Sule 
Published: July 2022

Abstract
ABSTRACT
Mental imagery is the mental re-creation of perceptual experiences, events and scenarios, and motor acts. In our previous study, we assessed whether motor imagery (MI) training combined with functional magnetic resonance imaging-based neurofeedback could improve the motor function of nondemented subjects with mild Parkinson’s disease (PD) (N=22). We used visual imagery (VI) (e.g., of scenes or events, but not of self-movements) training without neurofeedback for the control group (N=22). Notably, both groups showed significant and comparable improvement in motor function after four weeks of daily imagery practice. In this study, we further examined the neural correlates of the motor enhancement as a result of the VI training by analyzing the self-reported VI content during daily practice and relating its quality to the functional connectivity characteristics of the same subjects. We demonstrated that the VI practice encompassed multisensory, spatial, affective, and executive processes all of which are also important for motor function in real life. Subjects with worse global disease severity also showed poorer quality of the VI content. Finally, the quality of the VI content showed significant positive correlations with the functional connectivity changes during the VI tasks in brain areas supporting visuospatial and sensorimotor processes. Our findings suggest that mental imagery training combining VI and MI may enhance motor function in patients with mild PD, and more broadly, underline the importance of incorporating self-reports of thoughts and experiences in neuroimaging studies that examine the brain mechanisms of complex cognitive processes especially in neuropsychiatric patient populations.
Vegetation Assessments Under the Influence of Environmental Variables; A Case Study from the Yakhtangay hill of Himalayan range, Pakistan
Authors: Khan Hameed Ullah , Khan Shujaul Mulk Khan , Khan Zahid Ullah , Khan Zeeshan Ahmad , Jahangir Sadia Jahangir 
Published: July 2022

Abstract
The interrelationship between vegetation and abiotic variables inside an ecosystem is one of the main jobs of plant scientist. This study was designed to investigate the vegetation structure and species diversity along the environmental variables in the Yakhtangay hill district Shangla of the Himalayan Mountain series Pakistan, by using multivariate statistical analysis. Quadrat’s method was used and a total of 171 Quadrats were laid down 57 for Tree, Shrubs and Herbs respectively, to analyze the phytosociological attributes of the vegetation. The vegetation of the selected area was classified into different Life and leaf forms according to Raunkiaer classification, while PCORD software version 5 was used to classify the vegetation into different plants communities by Two-way indicator species Analysis (TWINSPAN). The CANOCCO version 4.5 was used for DCA and CCA analysis to find out variation directories of vegetation with different environmental variables. A total of 114 plants species belonging to 45 different families was investigated inside the area. The Rosaceae was the dominant family followed by Poaceae and then Asteraceae. Monocots were dominant than Dicots and Angiosperms were dominant than Gymnosperms. Among the life forms the Hemicryptophytes and Nanophanerophytes were dominant followed by Therophytes, while among the leaf forms Microphylls were dominant followed by Leptophylls. It is concluded that among the edaphic factors such as soil pH, the concentration of soil organic matter, Calcium Carbonates concentration in soil, soil EC, soil TDS, and physiographic factors such as Altitude and slope are affecting the structure of vegetation, species composition and species diversity at the significant level with p-value ≤ 0.05. The Vegetation of the selected area was classified into four major plants communities and the indicator species for each community was recorded. Classification of plants into 4 different communities based upon edaphic gradients favors the individualistic hypothesis. Indicator Species Analysis (ISA) shows the indicators of the study area are mostly indicators to the Himalayan or moist temperate ecosystem, furthermore these indicators could be considered for micro-habitat conservation and respective ecosystem management plans.
LY294002 attenuates neutrophilic airway inflammation and inhibits NLRP3 inflammasome activation in an OVA-LPS-induced asthma murine model
Authors: Lv Yunxiang , Jiang Guiyun 
Published: July 2022

Abstract
Background: Existing investigations suggest that the blockade of phosphoinositide 3-kinase (PI3K) activity contributes to inflammatory solution in allergic asthma, but whether this inhibition directly attenuates neutrophilic airway inflammation in vivo is still unclear. We explored the pharmacological effects of LY294002, a specific inhibitor of PI3K on the progression of neutrophilic airway inflammation and investigated the underlying mechanism. Methods and Results: Female C57BL/6 mice were intranasally sensitized with ovalbumin (OVA) together with LPS on days 0 and 6, and challenged with OVA on days 14-17 to establish a neutrophilic airway disease model. In the challenge phase, a subset of mice was treated intratracheally with LY294002. We found that treatment of LY294002 attenuates clinic symptoms of inflammatory mice. Histological studies showed that LY294002 significantly inhibited inflammatory cell infiltration and mucus production. The treatment also significantly inhibited OVA-LPS induced increases in inflammatory cell counts, especially neutrophil counts, and IL-17 levels in bronchoalveolar lavage fluid (BALF). LY294002 treated mice exhibited significantly increased IL-10 levels in BALF compared to the untreated mice. In addition, LY294002 reduced the plasma concentrations of IL-6 and IL-17. The anti-inflammatory effects of LY29402 were correlated with the downregulation of NLRP3 inflammasome. Conclusions: Our findings suggested that LY294002 as a potential pharmacological target for neutrophilic airway inflammation.