bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of cardiac‐specific IGF‐IIRα accelerates the development of liver dysfunction through STZ‐induced diabetic hepatocyte damage in transgenic rats
Authors: Li Chi‐Cheng , Ramesh Samiraj , Liu Tzu‐Yang , Wang Tso‐Fu , Kuo Wei‐Wen , Kuo Chia‐Hua , Chang Yung‐Ming , Hsieh Dennis Jine‐Yuan , Chen Ming‐Cheng , Huang Chih‐Yang 
Published: August 2022

AbstractThis study reports the effect of cardiac‐specific insulin‐like growth factor‐II receptor α (IGF‐IIRα) overexpression on the development of liver dysfunction in transgenic rats via STZ‐induced diabetic hepatocyte damage. The cardio‐hepatic syndrome comprises a number of heart and liver illnesses in which an acute or chronic disease in one organ can lead to acute or chronic disease in the other. However, the molecular mechanism involved in such a set of conditions is unclear. In this study, we developed a transgenic rat model with cardiac‐specific overexpression of IGF‐IIRα, which is a supplementary splicing variant of insulin‐like growth factor‐II receptor (IGF‐IIR), expressed in pathological hearts, to investigate the relationship between late fetal gene expression in diabetic hearts and their influence on diabetic hepatopathy. STZ (55 mg/kg) was intraperitoneally delivered into IGF‐IIR overexpressed transgenic (TG) and non‐transgenic (NTG) animal models developed in Sprague–Dawley (SD) rats after an overnight fast. The relationship among IGF‐IIRα overexpression and hepatocyte damages have been determined based on the complexity of damage in the liver. Our findings revealed that overexpression of the cardiac‐specific IGF‐IIRα enhances diabetes‐induced morphological alterations and hepatic inflammation in the livers. The diabetic transgenic rats demonstrated the development of pathological conditions such as thick collagen fiber deposition, bridging fibrosis, and elevation of α‐SMA and MMP1 related liver fibrosis mechanisms. Our data suggest that IGF‐IIRα overexpression in the heart during a pathological state may worsen diabetic hepatopathy in rats.
Einleitung
Authors: Jaehrling Karen , Stiehm Christin 
Published: August 2022

ZusammenfassungMit der Durchführung öffentlicher Dienstleistungen werden zunehmend private Unternehmen beauftragt. Wie dies genau geschieht, wer darauf Einfluss nimmt, und was das für die Arbeitsbedingungen bei den beauftragten Firmen bedeutet, thematisiert dieses Buch. Neben der konzeptionellen Grundlage ('politische Mikrokönomie der Vermarktlichung') erläutert die Einleitung die methodischen und empirischen Grundlagen der Untersuchung und stellt Kernbefunde vor.
Qualitative Wende in der Auftragsvergabe: Neue Entscheidungsstrukturen und -strategien auf dem Weg zu ‚mehr Qualität‘
Authors: Jaehrling Karen , Stiehm Christin 
Published: August 2022

ZusammenfassungIn diesem Kapitel liegt der Fokus zunächst auf den Vorgehensweisen der Verwaltung in ihrem Bemühen, sich vom ‚Diktat des billigsten Preises‘ zu entfernen, sowie auf den Schwierigkeiten und Gelingensbedingungen für diese Lernprozesse. Die untersuchten Kommunen haben ihre Vergabeprozesse zwar in der jüngeren Zeit mit dem Ziel der Professionalisierung reorganisiert. Die weiterhin dynamische Gesetzesentwicklung und Rechtsprechung und der damit verbundene chronisch unvollständige Charakter vergaberechtlicher Expertise tragen aber dazu bei, dass das Handeln unter (v.a. Rechts-)Unsicherheit dennoch ein zentrales Merkmal von Entscheidungsprozessen in der Vergabepraxis bleibt. Zugleich setzen, auch gestützt durch die neuen Verfahren des Bieterschutzes, die institutionellen Strukturen für das Verwaltungspersonal starke Anreize, sich am alten Prinzip der Rechtskonformität zu orientieren. In diesem Spannungsfeld aus Rechtskonformität und Rechtsunsicherheit entwickeln die Akteure unterschiedliche grundsätzliche Herangehensweisen, wie sie sich neue Entscheidungsspielräume zugunsten einer Vergabe nach Qualitätsgesichtspunkten erschließen.
Magnetic moments of leptons, charged lepton flavor violations and dark matter phenomenology of a minimal radiative Dirac neutrino mass model
Authors: De Bibhabasu , Das Debottam , Mitra Manimala , Sahoo Nirakar 
Published: August 2022

Abstract
In a simple extension of the standard model (SM), a pair of vector like lepton doublets (L1 and L2) and a SU(2)L scalar doublet (η) have been introduced to help in accommodating the discrepancy in determination of the anomalous magnetic moments of the light leptons, namely, e and μ. Moreover, to make our scenario friendly to a Dirac like neutrino and also for a consistent dark matter phenomenology, we specifically add a singlet scalar (S) and a singlet fermion (ψ) in the set-up. However, the singlet states also induce a meaningful contribution in other charged lepton processes. A discrete symmetry $$ {\mathcal{Z}}_2\times {\mathcal{Z}}_2^{\prime } $$

Z
2

×

Z
2
′

has been imposed under which all the SM particles are even while the new particles may be assumed to have odd charges. In a bottom-up approach, with a minimal particle content, we systematically explore the available parameter space in terms of couplings and masses of the new particles. Here a number of observables associated with the SM leptons have been considered, e.g., masses and mixings of neutrinos, (g − 2) anomalies of e, μ, charged lepton flavor violating (cLFV) observables and the dark matter (DM) phenomenology of a singlet-doublet dark matter. Neutrinos, promoted as the Dirac type states, acquire mass at one loop level after the discrete $$ {\mathcal{Z}}_2^{\prime } $$

Z
2
′

symmetry gets softly broken, while the unbroken $$ {\mathcal{Z}}_2 $$

Z
2

keeps the dark matter stable. The mixing between the singlet ψ and the doublet vector lepton can be constrained to satisfy the electroweak precision observables and the spin independent (SI) direct detection (DD) cross section of the dark matter. In this analysis, potentially important LHC bounds have also been discussed.
Precision medicine in type 1 diabetes
Authors: Carr Alice L. J. , Evans-Molina Carmella , Oram Richard A. 
Published: August 2022

AbstractFirst envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual’s unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1 diabetes diagnosis, treatment, prevention and prediction. These advances have been facilitated by the recognition of type 1 diabetes as an autoimmune disease and by advances in our understanding of diabetes pathophysiology, genetics and natural history, which have occurred in parallel with advancements in insulin delivery, glucose monitoring and tools for self-management. In this review, we discuss how these personalised approaches have improved diabetes care and how improved understanding of pathogenesis and human biology might inform precision medicine in the future.
Graphical abstract
Patient education on subacromial impingement syndrome
Authors: Jessen Malik , Lorenz Christina , Boehm Elisabeth , Hertling Stefan , Hinz Maximilian , Imiolczyk Jan-Philipp , Pelz Carsten , Ameziane Yacine , Lappen Sebastian 
Published: August 2022

Abstract
Objective
The purpose of this study was to assess the reliability and educational quality of content available on Google and YouTube regarding subacromial impingement syndrome (SAIS).

Methods
Google and YouTube were queried for English and German results on SAIS using the search terms “shoulder impingement” and the German equivalent “Schulter Impingement”. The analysis was restricted to the first 30 results of each query performed. Number of views and likes as well as upload source and length of content were recorded. Each result was evaluated by two independent reviewers using the Journal of the American Medical Association (JAMA) benchmark criteria (score range, 0–5) to assess reliability and the DISCERN score (score range, 16–80) and a SAIS-specific score (SAISS, score range, 0–100) to evaluate educational content.

Results
The 58 websites found on Google and 48 videos found on YouTube were included in the analysis. The average number of views per video was 220,180 ± 415,966. The average text length was 1375 ± 997 words and the average video duration 456 ± 318 s. The upload sources were mostly non-physician based (74.1% of Google results and 79.2% of YouTube videos). Overall, there were poor results in reliability and educational quality, with sources from doctors having a significantly higher mean reliability measured in the JAMA score (p < 0.001) and educational quality in DISCERN (p < 0.001) and SAISS (p = 0.021). There was no significant difference between German and English results but texts performed significantly better than videos in terms of reliability (p = 0.002) and educational quality (p < 0.001).

Conclusion
Information on SAIS found on Google and YouTube is of low reliability and quality. Therefore, orthopedic health practitioners and healthcare providers should inform patients that this source of information may be unreliable and make efforts to provide patients with higher quality alternatives.
Level of evidence: IV, case series.
A Stronger Lower Bound on Parametric Minimum Spanning Trees
Authors: Eppstein David 
Published: August 2022

AbstractWe prove that, for an undirected graph with n vertices and m edges, each labeled with a linear function of a parameter $$\lambda $$
λ
, the number of different minimum spanning trees obtained as the parameter varies can be $$\Omega (m\log n)$$

Ω
(
m
log
n
)

.
Evidence-based clinical practice guidelines for chronic pancreatitis 2021
Authors: Shimizu Kyoko , Ito Tetsuhide , Irisawa Atsushi , Ohtsuka Takao , Ohara Hirotaka , Kanno Atsushi , Kida Mitsuhiro , Sakagami Junichi , Sata Naohiro , Takeyama Yoshifumi , Tahara Junko , Hirota Morihisa , Fujimori Nao , Masamune Atsushi , Mochida Satoshi , Enomoto Nobuyuki , Shimosegawa Tooru , Koike Kazuhiko 
Published: August 2022

AbstractBackgroundChronic pancreatitis (CP) is defined according to the recently proposed mechanistic definition as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental, and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress.MethodsThe clinical practice guidelines for CP in Japan were revised in 2021 based on the 2019 Japanese clinical diagnostic criteria for CP, which incorporate the concept of a pathogenic fibro-inflammatory syndrome in the pancreas. In this third edition, clinical questions are reclassified into clinical questions, background questions, and future research questions.ResultsBased on analysis of newly accumulated evidence, the strength of evidence and recommendations for each clinical question is described in terms of treatment selection, lifestyle guidance, pain control, treatment of exocrine and endocrine insufficiency, and treatment of complications. A flowchart outlining indications, treatment selection, and policies for cases in which treatment is ineffective is provided. For pain control, pharmacological treatment and the indications and timing for endoscopic and surgical treatment have been updated in the revised edition.ConclusionsThese updated guidelines provide clinicians with useful information to assist in the diagnosis and treatment of CP.
Reoralisierung nach Intubation bei Intensivaufenthalt
Authors: Plementas Martina , Trapl-Grundschober Michaela 
Published: August 2022

ZusammenfassungDie Schluckfunktion kann durch eine Intubation stark beeinträchtigt werden. Essen und Trinken, aber auch Speichelschlucken können dadurch massiv gestört werden. In diesem Fall konnten einer jungen, multimorbiden Frau durch die Zusammenarbeit des gesamten medizinischen Personals die Nahrungsaufnahme wieder ermöglicht und die Lebensqualität gesteigert werden.
Eight things you should never do in a monitoring program: an Australian perspective
Authors: Lindenmayer David B. , Woinarski John , Legge Sarah , Maron Martine , Garnett Stephen T. , Lavery Tyrone , Dielenberg Jaana , Wintle Brendan A. 
Published: August 2022

AbstractMonitoring is critical to gauge the effect of environmental management interventions as well as to measure the effects of human disturbances such as climate change. Recognition of the critical need for monitoring means that, at irregular intervals, recommendations are made for new government-instigated programs or to revamp existing ones. Using insights from past well-intentioned (but sadly also often failed) attempts to establish and maintain government-instigated monitoring programs in Australia, we outline eight things that should never be done in environmental monitoring programs (if they aim to be useful). These are the following: (1) Never commence a new environmental management initiative without also committing to a monitoring program. (2) Never start a monitoring program without clear questions. (3) Never implement a monitoring program without first doing a proper experimental design. (4) Never ignore the importance of matching the purpose and objectives of a monitoring program to the design of that program. (5) Never change the way you monitor something without ensuring new methods can be calibrated with the old ones. (6) Never try to monitor everything. (7) Never collect data without planning to curate and report on it. (8) If possible, avoid starting a monitoring program without the necessary resources secured. To balance our “nevers”, we provide a checklist of actions that will increase the chances a monitoring program will actually measure the effectiveness of environmental management. Scientists and resource management practitioners need to be part of a stronger narrative for, and key participants in, well-designed, implemented, and maintained government-led monitoring programs. We argue that monitoring programs should be mandated in threatened species conservation programs and all new environmental management initiatives.
Electrochemical investigation of ion-beam sputter-deposited carbon thin films for Li-ion batteries
Authors: Hüger Erwin , Jin Chao , Schmidt Harald 
Published: August 2022

Abstract
The C-rate capability of 230 nm- and 16 nm-thin ion-beam sputter-deposited amorphous carbon films, an interesting class of carbonaceous material for lithium-ion batteries, was investigated up to Li-platting. Stepwise ascending and descending constant Li+ currents after each fifth cycle, followed by hundreds of cycles with the highest current were applied. The carbon films show similar cycling with irreversible losses during the first five cycles, followed by reversible cycling with a capacity close to that of graphite. The capacity is significantly lower at high currents; however, it is restored for subsequent cycling again at low currents. Differential charge and differential capacity curves reveal three Li+ uptake and three Li+ release peaks located between 0 and 3 V. Irreversible as well as reversible Li bonding can be associated with all these peaks. Irreversibly bonded Li can be found at the surface (solid electrolyte interphase) and in the bulk of the carbon films (Li trapping). Reversible Li bonding might be possible inside the carbon films in graphite-like nano-domains and at defects. The thinner film reveals a more pseudo-capacitive cycling behavior, pointing to enhanced Li kinetics.

Graphical abstract
Sintering condition-dependent electromechanical behavior of the lead-free piezoelectric Bi1/2K1/2TiO3
Authors: Eyoum Gina E. , Eckstein Udo , Riess Kevin , Gadelmawla Ahmed , Springer Eva , Webber Kyle G. , Khansur Neamul H. 
Published: August 2022

AbstractSintering conditions govern the optimized functional properties of ceramics. However, solid-state processing of Bi1/2K1/2TiO3 (BKT), an important end member for lead-free piezoelectric solid solutions suitable for higher temperature (≤ 300 °C) transducer applications, is challenging due to the low melting temperature (≈1070 °C). In this work, the sintering temperature (1030 °C, 1050 °C, and 1060 °C) and dwell time (10 h, 20 h, and 40 h)-dependent functional properties of solid-state processed BKT were investigated, where the sintering condition-dependent dielectric and electromechanical properties were correlated with the variations in crystal structure and microstructure. Although X-ray diffraction data revealed a single-phase tetragonal structure of BKT at room temperature for all sintering conditions, significant changes in both the tetragonal distortion and spontaneous relaxor-ferroelectric transition were observed, which were directly related to the optimized functional properties. In addition, Rayleigh behavior of the piezoelectric coefficient was characterized between −150 °C and 400 °C, demonstrating that the electromechanical response is dominated by the intrinsic contribution, which can be explained by large tetragonal distortion and associated suppression of non-180° domain wall motion.
Pulse Shape Analysis in Low-temperature Calorimeters Read-Out by NTD Thermistors
Authors: Biassoni M. , Brofferio C. , Carniti P. , Faverzani M. , Ferri E. , Ghislandi S. , Giachero A. , Gotti C. , Nutini I. , Pessina G. , Quitadamo S. 
Published: August 2022

AbstractWe present the application of a simplified thermal model for the description of the response function of low-temperature calorimeters consisting of $$\hbox {TeO}_2$$

TeO
2

crystals read-out by NTD thermistors operated at temperatures $$T \sim 10$$

T
∼
10

mK. Relying on both the analysis of the NTD load curves (from which we measured the main thermal conductances of the system) (Biassoni et al. in J Low Temp Phys 206:80–96, 2022) and on the analysis of the shape of thermal pulses acquired at different temperatures, we identified and quantified the physical parameters that determine the characteristic time constants of the pulses. In particular, we identified three different contributions to the heat capacity of the detector: the crystal phonon system (scaling as $$T^3$$

T
3

), the NTD electron system (scaling as T) and a term related to the metalization process of the NTD electrodes (scaling as $$T^{-2}$$

T

-
2

).
Meshfree Semi-Lagrangian Methods for Solving Surface Advection PDEs
Authors: Petras Argyrios , Ling Leevan , Ruuth Steven J. 
Published: August 2022

AbstractWe analyze a class of meshfree semi-Lagrangian methods for solving advection problems on smooth, closed surfaces with solenoidal velocity field. In particular, we prove the existence of an embedding equation whose corresponding semi-Lagrangian methods yield the ones in the literature for solving problems on surfaces. Our analysis allows us to apply standard bulk domain convergence theories to the surface counterparts. In addition, we provide detailed descriptions for implementing the proposed methods to run on point clouds. After verifying the convergence rates against the theory, we show that the proposed method is a robust building block for more complicated problems, such as advection problems with non-solenoidal velocity field, inviscid Burgers’ equations and systems of reaction advection diffusion equations for pattern formation.
Optimistic optimisation of composite objective with exponentiated update
Authors: Shao Weijia , Sivrikaya Fikret , Albayrak Sahin 
Published: August 2022

AbstractThis paper proposes a new family of algorithms for the online optimisation of composite objectives. The algorithms can be interpreted as the combination of the exponentiated gradient and p-norm algorithm. Combined with algorithmic ideas of adaptivity and optimism, the proposed algorithms achieve a sequence-dependent regret upper bound, matching the best-known bounds for sparse target decision variables. Furthermore, the algorithms have efficient implementations for popular composite objectives and constraints and can be converted to stochastic optimisation algorithms with the optimal accelerated rate for smooth objectives.
Health-related quality of life of Australians during the 2020 COVID-19 pandemic: a comparison with pre-pandemic data and factors associated with poor outcomes
Authors: Mercieca-Bebber Rebecca , Campbell Rachel , Fullerton Dayna Jan , Kleitman Sabina , Costa Daniel S. J. , Candelaria Dion , Tait Margaret Ann , Norman Richard , King Madeleine 
Published: August 2022

Abstract
Purpose
Compare the health-related quality of life (HRQL) of the Australian general population during the COVID-19 pandemic (2020) with pre-pandemic data (2015–2016) and identify pandemic-related and demographic factors associated with poorer HRQL.

Methods
Participants were quota sampled from an online panel by four regions (defined by active COVID-19 case numbers); then by age and sex. Participants completed an online survey about their HRQL [EORTC QLQ-C30 questionnaire and General Health Question (GHQ)], demographic characteristics, and the impact of the pandemic on daily life. HRQL scores were compared to a 2015–2016 reference sample using independent t-tests, adjusted for multiple testing. Associations between 22 pre-specified factors (pandemic-related and demographic) and 15 QLQ-C30 domains and GHQ, were assessed with multiple regressions.

Results
Most domains were statistically significantly worse for the 2020 sample (n = 1898) compared to the reference sample (n = 1979), except fatigue and pain. Differences were largest for the youngest group (18–29 years) for cognitive functioning, nausea, diarrhoea, and financial difficulties. Emotional functioning was worse for 2020 participants aged 18–59, but not for those 60 +.
All models were statistically significant at p < .001; the most variance was explained for emotional functioning, QLQ-C30 global health/QOL, nausea/vomiting, GHQ, and financial difficulties. Generally, increased workload, negative COVID-19 impacts, COVID-19-related worries, and negative attitudes towards public health order compliance were associated with poorer HRQL outcomes.

Conclusion
During the COVID-19 pandemic, Australians reported poorer HRQL relative to a pre-pandemic sample. Risk factors for poor HRQL outcomes included greater negative pandemic-related impacts, poorer compliance attitudes, and younger age.

Trial registration
ANZCTR number is: ACTRN12621001240831. Web address of your trial: https://www.anzctr.org.au/ACTRN12621001240831.aspx. Date submitted: 26/08/2021 2:56:53 PM. Date registered: 14/09/2021 9:40:31 AM. Registered by: Margaret-Ann Tait. Principal Investigator: Madeleine King.
Domain expertise extraction for finding rising stars
Authors: Zhu Lin , Zhang Junjie , Cunningham Scott W. 
Published: August 2022

AbstractThe field of expertise extraction utilizes published research enabling communities to highlight and identify the skills of researchers within specific scientific domains. This can be useful for evaluating research performance, and in the case of rising stars, in identifying top scientific talent. Previous research has harvested a range of publication indicators in an effort to identify expertise and talent. These include content indicators, citation metrics, and also the position of a researcher within a full collaboration network of scientists. The existing mechanism of expertise extraction utilizes all papers attributed to a scientific author, thereby potentially neglecting their specific or specialized expertise. Here we show that a tensor decomposition technique when applied to the problem addresses a number of useful problems. This includes better identification of individual expertise, as well as an integrated appraisal of an author’s role in an extended scientific network. The technique will afford new analyses of knowledge production which consider specialisation and diversity as core elements for further analysis. More generally the tensor decomposition techniques presented in this paper can be applied to a range of scientometric problems where multi-modal data is encountered.