bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: AL Amyloidosis Severe Restrictive Cardiomyopathy Associated With Multiple Myeloma—Diagnostic Difficulties
Authors: Kirichenko Yulia Y. , Ilgisonis Irina S. , Nakhodnova Elena S. , Sokolova Irina Y. , Bochkarnikova Olga V. , Kardanova Sabina A. , Lyapidevskaya Olga V. , Privalova Elena V. , Ershov Vladimir I. , Belenkov Yurii N. 
Published: June 2022

BackgroundCardiac AL amyloidosis as a complication of multiple myeloma (MM) is a formidable life-threatening condition. The first-line therapy for both MM and systemic AL amyloidosis is proteasome inhibitors (PIs). Unfortunately, the use of PIs may lead to cardiovascular toxicity development, which requires specific cardio-oncology supervision.Case ReportA 57-year-old woman was admitted to a university hospital with clinical manifestation of progressive chronic heart failure. The patient had hypertension and no history of diabetes mellitus, myocardial infarction (MI), stroke, and arrhythmias. After a series of laboratory and instrumental examination methods, MM complicated by cardiac AL amyloidosis was proved. Upon specific cardio-oncology examination (NT-proBNP 4,274 pg/ml), ECHO showed systolic dysfunction, motion abnormalities in LV basal and middle segments, and a typical depositional myocardium pattern (“luminescence”); cardiac MRI revealed restrictive cardiomyopathy and specific hyperenhancement of the ventricles and atria; 24-h ECG showed QS-pattern in leads V1–V3 and unstable ventricular tachycardia (VT) paroxysms. Cardio-oncology consultation showed baseline cardiovascular risk was very high (≥20%), and cardioprotective therapy [iACE/ARBs, beta-blockers (BB), statins] was administered. The patient underwent VCD (bortezomib; cyclophosphamide; dexamethasone) chemotherapy (CMT) program. By the time of publication, the patient had received four CMT courses with a positive oncohematological and cardiovascular effect.ConclusionIn this clinical case, we described a complication of MM, which was rare according to the severity and manifestation with restrictive cardiomyopathy due to secondary cardiac amyloidosis. The case's features were difficulties in verifying the underlying disease and its own complication, and the complexity of patient management according to modern principles of cardio-oncology.
Metyrapone Versus Osilodrostat in the Short-Term Therapy of Endogenous Cushing’s Syndrome: Results From a Single Center Cohort Study
Authors: Detomas Mario , Altieri Barbara , Deutschbein Timo , Fassnacht Martin , Dischinger Ulrich 
Published: June 2022

BackgroundAlthough surgery is considered the first-line treatment for patients with endogenous Cushing’s syndrome (CS), medical therapy is often required to control severe hypercortisolism. Metyrapone and osilodrostat are both steroidogenic inhibitors targeting the 11β-hydroxylase, however, their therapeutic effectiveness has not yet been directly compared. This study aimed to evaluate metyrapone and osilodrostat in the short-term therapy of CS.MethodsRetrospective analysis of patients with endogenous CS treated with metyrapone or osilodrostat as monotherapy for at least 4 weeks. Main outcome measures were serum cortisol and 24h urinary free cortisol (UFC) at baseline (T0) and after 2 (T1), 4 (T2), and 12 weeks (T3) of therapy.Results16 patients with endogenous CS were identified (pituitary n=7, adrenal n=4, ectopic CS n=5). Each 8 patients were treated with metyrapone and osilodrostat. Despite heterogeneity, both groups showed comparable mean UFC levels at T0 (metyrapone: 758 µg/24h vs osilodrostat: 817 µg/24h; p=0.93). From T0 to T1, the decrease of UFC was less pronounced under metyrapone than osilodrostat (-21.3% vs -68.4%; median daily drug dose: 1000 mg vs 4 mg). This tendency persisted at T2 (-37.3% vs -50.1%; median drug dose: 1250 mg vs 6 mg) while at T3 a decrease in UFC from T0 was more pronounced in the metyrapone group (-71.5% vs -51.5%; median dose 1250 mg vs 7 mg). Under osilodrostat, a QTc-interval prolongation was identified at T3 (mean 432 ms vs 455 ms). From T0 to T2, the number of antihypertensive drugs remained comparable under metyrapone and decreased under osilodrostat (n= -0.3 vs n= -1.0).ConclusionAlthough both drugs show comparable therapeutic efficacy, osilodrostat seems to reduce cortisol levels and to control blood pressure faster.
Arthrospira Cell Residues for Lactic Acid Fermentation as Bioproducts From Waste Utilization
Authors: Pan-utai Wanida , Thitiprasert Sitanan , Pornpukdeewattana Soisuda 
Published: June 2022

Arthrospira(Spirulina)platensisis a freshwater cyanobacterium that is commercially produced as a food source on a global scale and considered safe for human consumption. After C-phycocyanin (C-PC) extraction, the waste cell residue (WCR) is composed of nutrients with 30% protein content. Here, the potential of WCR as a nitrogen source forBacillus coagulanscultivation and bioproducts was evaluated. Nitrogen substitute from WCR under different conditions of 20—100 g L−1was performed.B. coagulanscultivation was achieved with maximal viable cells at 7.6–9.5 log CFU mL−1. Increasing WCR gave decreasing lactate production. The highest lactate production at 27 g L−1was achieved from WCR 20 g L−1, highlighting the potential use ofA. platensiswaste biomass residue as a nitrogen source for the growth of lactic acid bacteria and zero-waste biotechnology methodology. The utilization of renewable resources is a crucial step toward developing a sustainable industrial society.
Effect of Center-Pivot Irrigation Intensity on Groundwater Level Dynamics in the Agro-Pastoral Ecotone of Northern China
Authors: Lian Jie , Li Yulin , Li Yuqiang , Zhao Xueyong , Zhang Tonghui , Wang Xinyuan , Wang Xuyang , Wang Lilong , Zhang Rui 
Published: June 2022

Groundwater-based irrigation is an effective buffer against water disconnects during droughts in areas of intensive agriculture. However, it is difficult to implement effective measures to sustainably utilize aquifers due to the unclear understanding of irrigation intensity in the agro-pastoral ecotone. To explore the influence of regional irrigation intensity on groundwater level (GL), we investigated the dynamics of Kernel density for irrigation well from 2000 and the changed GL (ΔGL in three groups) in a typical center-pivot irrigation (CPI) area (about 1,000 km2). The results showed that the implementation of CPI systems caused a rapid land-use change from natural grassland (NG) to cultivated pasture (CP). The observed ΔGL in deeper group (0.63 m yr−1, GL &gt; 20 m) was significantly (p &lt; 0.05) higher than that in shallower group (0.38 m yr−1, GL &lt; 10 m) and medium group (0.43 m yr−1, 10 m &lt; GL &lt; 20 m). The predicted ΔGL and GL were significantly and positively correlated with the CPI well density (R2 = 0.447 and 0.429, p &lt; 0.001), respectively, and showed a fitted plane function based on the variables (R2 = 0.655, p &lt; 0.001). It indicted that the intensive cropping in the agro-pastoral ecotone profoundly changed regional irrigation intensity, resulting in a rapid response of the GL. To reduce the risk of increased irrigation costs and ensure sustainable availability of groundwater, it’s necessary to control the density of CPI systems in hotspot areas, and implement water-saving measures to balance water usage and recharge rates for sustainable groundwater management.
Spatiotemporal Variation in Ecological Risk on Water Yield Service via Land-Use and Climate Change Simulations: A Case Study of the Ziwuling Mountainous Region, China
Authors: Jin Tiantian , Yan Lingling , Wang Shimei , Gong Jie 
Published: June 2022

Scientists have paid attention to assessing the change in ecosystem service risk under human activities, yet few works have focused on the water yield risk induced by land-use and climate change. In this study, a framework combining water yield with ecological risk for service enhancement and human adaptation was established. The framework was applied to explore the spatiotemporal variation in water yield service and its ecological risk via land-use and climate change scenarios in the Ziwuling Mountainous Region (ZMR), China, using InVEST, CA–Markov, and TOPSIS models. The water yield service decreased from 69.19 mm in 1990 to 47.72 mm in 2017 in the ZMR. The water yield service in the southeast ZMR was larger than that in the northwest. The water yield service risk was high and increased first, then decreased from 1990 to 2017 in the ZMR. The high-risk and higher risk subareas were distributed in the middle and north of the ZMR. The water yield service is the highest under the EC126 scenario (48.09 mm in 2050 and 43.73 mm in 2100) and the lowest under the EP585 scenario (43.52 mm in 2050 and 40.62 mm in 2100). The water yield service risk of the EP558 scenario is the largest one, with an area ratio of the high risk of 83.95% in 2050 and 85.33% in 2100. We suggest developing water-saving agriculture and high-efficiency industrial systems, as well as ecological restoration and integrated forest social–ecological management for risk alleviation, service enhancement, and sustainable development.
Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis
Authors: Yang Jianhua , Liu Mengyao , Wang Shu , Gan Yuanxiu , Chen Xiangyu , Tao Yang , Gao Junwei 
Published: June 2022

IntroductionResistin is a small secretory adipokine which is implicated to obesity and associated diseases. Recently, plenty of research papers have been conducted to explore the association between peripheral resistin and the severity of acute pancreatitis (AP). However, the results were controversial. In this study, we aimed to confirm the effect of peripheral resistin and the development of acute pancreatitis.MethodsA comprehensive online search was performed using the PubMed, Embase, Web of Science, CNKI, and Wanfang databases up through January 20, 2022. The retrieved records and their references were screened to identify additional studies. Data were extracted to calculate the pooled Hedges' g and its 95% CI, which were selected to assess peripheral resistin levels and the severity of acute pancreatitis. Subgroup analyses, sensitivity analyses, meta-regression, and publication bias tests were also undertaken based on obtained information.ResultsA total of eleven studies with 892 acute pancreatitis patients were enrolled in the study. Peripheral resistin levels were significantly increased in severe acute pancreatitis compared with mild acute pancreatitis (Hedges' g = 2.092, 95% CI: 0.994–3.190, P &lt; 0.001). Subgroup analyses based on sample types and ethnicity also showed similar results. A single study did not affect our results, which was verified by sensitivity analysis. Meta-regression analyses revealed that age, gender of the included subjects, sample size, and publication year did not moderate effects on the present results.ConclusionIn our study, peripheral resistin levels were significantly elevated in patients with severe AP compared with patients with mild AP. Abnormal resistin levels may provide us some new insights in predicting the severity of AP.
Clinical Observation of Extensively Hydrolysis Protein Formula With Feeding Intolerance in Preterm Infants
Authors: Yin Liping , Ma Jingjing , Liu Heng , Gu Qianying , Huang Li , Mu Qi , An Ning , Qian LiJuan , Qiao Lixing 
Published: June 2022

ObjectiveTo investigate whether feeding extensively hydrolysis protein formula during the NICU hospitalization was more beneficial for preterm infants with a gestational age (GA) ≤34 weeks when breastfeeding was not possible.MethodsIn total, 587 preterm infants were randomly divided into two groups: observation groups fed with extensively hydrolyzed formula (EHF) milk and control groups fed with standard preterm formula (SPF) milk until discharge from the neonatal intensive care unit (NICU). The incidence of complications during hospitalization was recorded in both groups. Then, two groups were uniformly fed with 0-to-6-month infant formula milk and followed-up for 6 months after discharge.ResultsThe final study included 370 premature infants, including 185 babies in the observation group and 185 in the control group. In contrast to the SPF, feeding EHF among preterm infants of GA &lt;34 weeks during NICU hospitalization significantly reduced the incidence of feeding intolerance (FI) (14.1 vs. 30.3%, p &lt; 0.01). The incidence of necrotizing enterocolitis (NEC) was significantly reduced in the observation group (2.2 vs. 6.5%, p &lt; 0.05), but there was no significant difference in the incidence of other related complications. At discharge, there was no difference in total serum protein (46.6 vs. 46.4 g/L), albumin (33.5 vs. 34.2 g/L), and calcium (2.37 vs. 2.35 mmol/L), but the serum phosphorus concentrations associated with skeletal mineralization (2.10 vs. 2.22 mmol/L, p &lt; 0.05) was significantly reduced and alkaline phosphatase significantly rose (254 vs. 220 IU/L, p &lt; 0.05) in the observation group. No significant difference was found in the growth rates of body weight, head circumference, or body length, either during the NICU hospitalization or during the 6-month follow-up after discharge (p &gt; 0.05).ConclusionsFeeding premature infants of GA ≤34 weeks with EHF reduced the incidence of FI, but had no advantage in establishing whole intestinal nutrition, shortening parenteral nutrition (PN) time, or hospitalization time. It had little effect on physical growth or development during NICU hospitalization and within 6 months after discharge. However, it may increase the incidence of metabolic bone disease (MBD).
Differences in Postnatal Growth of Preterm Infants in Northern China Compared to the INTERGROWTH-21st Preterm Postnatal Growth Standards: A Retrospective Cohort Study
Authors: Zhang Li , Gao Nan-Nan , Liu Hui-Juan , Wu Qiong , Liu Ju , Zhang Ting , Sun Jin , Qi Jian-Hong , Qiao Xiu-Yun , Zhao Yan , Li Yan 
Published: June 2022

BackgroundThe INTERGROWTH-21st preterm postnatal growth standards (IPPGS) have increasingly been used to evaluate the growth of preterm infants worldwide. However, the validity of IPPGS's application to specific preterm populations remains controversial. This retrospective cohort study aimed to formulate reference growth charts for a preterm cohort in northern China and compare them to the IPPGS.MethodsA total of 1,827 healthy preterm infants with follow-up visits before 70 weeks of postmenstrual age (PMA) were retrospectively sampled from a preterm cohort (N = 2,011) born between 1 January 2011 and 28 February 2021, at the First Affiliated Hospital of Shandong First Medical University. Using the Generalized Additive Models for Location, Scale, and Shape method, 5,539 sets of longitudinal data were used to construct percentile and Z-score charts of length, weight, and head circumference (HC) at 40–64 weeks of PMA. Z-scores of length, weight, and HC (LAZ, WAZ, and HCZ) before 64 weeks were calculated using the IPPGS. Differences in the 50th percentile values between preterm infants and IPPGS (dLength, dWeight, and dHC) were calculated. Z-scores were assigned to six PMA clusters: 40–44, 44–48, 48–52, 52–56, 56–60, and 60–64 weeks for comparison between sexes.ResultsFor eligible infants, the mean PMA and weight at birth were 33.93 weeks and 2.3 kg, respectively. Boys, late preterm infants, twins, and infants with exclusively breastfeeding accounted for 55.8, 70.6, 27.8, and 45.9%, respectively. Compared to IPPGS, preterm infants were longer and heavier, especially for dLength in girls (range, 2.19–2.97 cm), which almost spanned the 50th and 90th percentiles of IPPGS. The dHC tended to narrow with PMA for both sexes. The mean LAZ, WAZ, and HCZ of both sexes at all PMA clusters were &gt;0, especially for LAZ and WAZ (about 1.0 relative to IPPGS), indicating higher levels than the IPPGS at 40–64 weeks. Girls had larger LAZ at each PMA cluster, larger WAZ at 40–44 weeks, and lower HCZ after 56 weeks than boys. HCZ declined with PMA for both sexes.ConclusionPostnatal growth of this preterm cohort was considerably higher than that of the IPPGS at 40–64 weeks of PMA with sex differences.
Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study
Authors: Zhao Mengnan , Chen Zhaoyan , Tian Fangyuan , Xu Ting 
Published: June 2022

Objectives: The purpose of this study was to explore the prevalence of potentially inappropriate medication (PIM) among older outpatients (age ≥ 65 years old) with dementia in eight cities in China using the AGS Beers criteria of 2019 and to identify the potential factor increasing the number of PIMs.Methods: A cross-sectional study about PIM in older outpatients with dementia from January 2020 to December 2020 was carried out in eight cities in China, Chengdu, Beijing, Guangzhou, Shanghai, Shenyang, Tianjin, Zhengzhou, and Hangzhou, distributing five major geographical regions in China (east, west, north, south, central). The diagnosis of dementia was based on the International Classification of Diseases (ICD-10) to identify. Based on the 2019 AGS Beers criteria, the PIM prescriptions were evaluated. The identification of potential factors was completed using a binary logistic regression model.Results: Of 18,624 older outpatients with dementia, 3.52% were detected with 1 PIM, and 35.91% received at least two PIMs. The antipsychotic drugs quetiapine and olanzapine were most frequently prescribed in patients with PIM, accounting for 8.01 and 7.36%, respectively. Logistic regression analyses showed that female patients with dementia aged &gt;80 years who took more medications were exposed easily to PIM use.Conclusion: PIM use among older outpatients with dementia in China is highly prevalent, and the associated risk factors were increasing age, female sex, and number of medications. The most frequently prescribed drugs by clinicians were anpsychotropic drugs, which were much more frequent than other drugs.
Efficacy and Safety of Various First-Line Therapeutic Strategies for Fetal Tachycardias: A Network Meta-Analysis and Systematic Review
Authors: Qin Jiangwei , Deng Zhengrong , Tang Changqing , Zhang Yunfan , Hu Ruolan , Li Jiawen , Hua Yimin , Li Yifei 
Published: June 2022

Background: Fetal arrhythmias are common cardiac abnormalities associated with high mortality due to ventricular dysfunction and heart failure, particularly when accompanied by hydrops. Although several types of common fetal tachycardias have been relatively identified medications, such as digoxin, flecainide, and sotalol, there is no first-line drug treatment protocol established for the treatment of various types of fetal tachycardias.Methods: We conducted a network meta-analysis using a Bayesian hierarchical framework to obtain a model for integrating both direct and indirect evidence. All tachycardia types (Total group), supraventricular tachycardia (SVT subgroup), atrial flutter (AF subgroup), hydrops subgroup, and non-hydrops subgroup fetuses were analyzed, and five first-line regimens were ranked according to treatment outcomes: digoxin monotherapy (D), flecainide monotherapy (F), sotalol monotherapy (S), digoxin plus flecainide combination therapy (DF), and digoxin plus sotalol combination therapy (DS). Effectiveness and safety were determined according to the cardioversion rate and intrauterine death rate.Results: The pooled data indicated that DF combination therapy was always superior to D monotherapy, regardless of the tachycardia type or the presence of hydrops: Total, 2.44 (95% CrI: 1.59, 3.52); SVT, 2.77 (95% CrI: 1.59, 4.07); AF, 67.85 (95% CrI: 14.25, 168.68); hydrops, 6.03 (95% CrI: 2.54, 10.68); and non-hydrops, 5.06 (95% CrI: 1.87, 9.88). DF and F had a similar effect on control of fetal tachycardias. No significant differences were observed when comparing S, DS with D therapies across the subgroup analyses for the SVT, hydrops, and non-hydrops groups. No significant differences in mortality risks were among the various treatment regimens for the total group. And no significant differences were found in rates of intrauterine death rates at the same cardioversion amount.Conclusion The flecainide monotherapy and combination of digoxin and flecainide should be considered the most superior therapeutic strategies for fetal tachycardia.Systematic Review Registration: (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=288997), identifier (288997).
Age Differences in Recovery Rate Following an Aerobic-Based Exercise Protocol Inducing Muscle Damage Among Amateur, Male Athletes
Authors: Markus Irit , Constantini Keren , Goldstein Nir , Amedi Roee , Bornstein Yael , Stolkovsky Yael , Vidal Merav , Lev-Ari Shahar , Balaban Roy , Leibou Stav , Blumenfeld-Katzir Tamar , Ben-Eliezer Noam , Peled David , Assaf Yaniv , Jensen Dennis , Constantini Naama , Dubnov-Raz Gal , Halperin Israel , Gepner Yftach 
Published: June 2022

Purpose: Compare recovery rates between active young (Y) and middle-aged (MA) males up to 48H post aerobically based, exercise-induced muscle damage (EIMD) protocol. A secondary aim was to explore the relationships between changes in indices associated with EIMD and recovery throughout this timeframe.Methods: Twenty-eight Y (n = 14, 26.1 ± 2.9y, 74.5 ± 9.3 kg) and MA (n = 14, 43.6 ± 4.1y, 77.3 ± 12.9 kg) physically active males, completed a 60-min downhill running (DHR) on a treadmill at −10% incline and at 65% of maximal heart rate (HR). Biochemical, biomechanical, psychological, force production and muscle integrity (using MRI diffusion tensor imaging) markers were measured at baseline, immediately-post, and up to 48H post DHR.Results: During the DHR, HR was lower (p &lt; 0.05) in MA compared to Y, but running pace and distance covered were comparable between groups. No statistical or meaningful differences were observed between groups for any of the outcomes. Yet, Significant (p &lt; 0.05) time-effects within each group were observed: markers of muscle damage, cadence and perception of pain increased, while TNF-a, isometric and dynamic force production and stride-length decreased. Creatine-kinase at 24H-post and 48H-post were correlated (p &lt; 0.05, r range = −0.57 to 0.55) with pain perception, stride-length, and cadence at 24H-post and 48H-post. Significant (p &lt; 0.05) correlations were observed between isometric force production at all time-points and IL-6 at 48H-post DHR (r range = −0.62 to (−0.74).Conclusion: Y and MA active male amateur athletes recover in a comparable manner following an EIMD downhill protocol. These results indicate that similar recovery strategies can be used by trainees from both age groups following an aerobic-based EIMD protocol.