bluuebunny/crossref_metadata_2025_split huggingface dataset:
­The Influence of Land Use and Land Cover Change on Landslide Susceptibility in the Lower Mekong River Basin
Authors: Dandridge Chelsea , Stanley Thomas , Kirschbaum Dalia , Amatya Pukar , Lakshmi Venkataraman 
Published: May 2022

Abstract
The Lower Mekong River Basin in Southeast Asia experiences frequent rainfall-triggered landslides especially during the monsoon season. In this study, the influence of land use and land cover (LULC) change and other causative factors on landslide susceptibility is evaluated in the Lower Mekong Basin. Frequency ratio analysis is performed to quantify the relationship between LULC change and susceptibility. Detailed landslide inventory maps are used for analysis with yearly LULC maps. The LULC change is used as a contributing variable in a logistic regression-based susceptibility model with other variables including distance to roads, slope, aspect, forest loss, and soil properties. The Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC) are estimated for the model trained by each landslide inventory. The models show good performance, with AUC values ranging from 0.697 to 0.958 and an average AUC equal to 0.820. Both the Frequency Ratio analysis and the Logistic Regression models indicate LULC change from agricultural land to forest has a positive correlation with landslide occurrence. The most significant factors in the models are found to be distance to roads, slope, and aspect. A better understanding of the effects of LULC on landslide susceptibility can be useful for local land and disaster management and for the implementation of LULC as a factor in future susceptibility models. Using datasets that are unique to the Lower Mekong region, this study provides additional insights into the relationship between causative factors and landslide activity to better inform regional and global landslide susceptibility modeling.
Clinical study on the relationship between neopterin and polycystic ovary syndrome
Authors: Zhou Junjie , Yang Mo , Liu Yingxue , Song Youlan , Lin Ru , Wu Han , Zhang Wenjuan 
Published: May 2022

Abstract
Background: Polycystic ovary syndrome (PCOS) is a reproductive endocrine and metabolic disorder. To offer new research direction for polycystic ovary syndrome (PCOS), including its pathogenesis and treatment, this research explores the relationship between neopterin (NPT) and polycystic ovary syndrome. Material and Methods: This is a prospective study. 40 cases with PCOS were selected in the reproductive medicine clinics of the Second Affiliated Hospital of Shandong First Medical University as PCOS group from January 2017 to December 2018. 40 cases with normal pregnancy plan were treated as non-PCOS group, whose menstruation is from 25 days to 35 days. We divided the two groups into two subgroups separately according to their body mass index (BMI): the obese one with BMI≥25kg/㎡and non-obese one with BMI<25kg/m2.Results: The expression levels of triglycerides (TG), total cholesterol (TC), fasting insulin (FINS), C-reactive protein (CRP), neutrophil (N), NPT and interleukin-6 (IL-6) in PCOS group were higher than non-PCOS group. CRP, NPT and IL-6 in the obese group were increased than the non-obese group in the pairwise comparison of its subgroups whether in PCOS group or non-PCOS group. In the analysis of linear correlation, NPT was positively correlated with TG, TC, WBC, N, CRP, FINS, IL-6 and TNF-α (P<0.01). Multivariate Stepwise regression analysis found that FINS and IL-6 was the two most important factors. Conclusion: The expression of NPT in PCOS patients was higher than non-PCOS. NPT maybe play a significant role in the development of PCOS.
Phenobarbital is Associated with Cholestasis in Preterm Infants with Hemo-dynamically Significant Patent Ductus Arteriosus
Authors: Shen Xintian , Huang Yie , Peng Haibo , Zhou Ping 
Published: May 2022

Abstract
Objectives: This retrospective study aimed to assess whether phenobarbital was associated with cholestasis in preterm infants with hemo-dynamically significant patent ductus arteriosus (hsPDA).Methods: This study included 151 preterm infants (24~34 weeks, birth weight<2000 g) diagnosed with hsPDA, admitted to a level III neonatal intensive care unit (NICU) from September 2016 to September 2019. Of the 151 infants, twenty-seven infants were diagnosed with cholestasis. To assess the independent association of phenobarbital with cholestasis, binary logistic regression was done, adjusting for major confounders (birth weight, gestational age, critical risk index for babies and etc).Result: To explore whether the risk of cholestasis was independently increased by duration of phenobarbital, binary logistic regression analysis was done adjusting for significant confounders (p<0.05). After adjustment with confounders “critical risk index for babies”, “invasive mechanical ventilation”, “any sepsis onset in 28 days” and “duration of cimetidine”, cholestasis was still associated with “duration of phenobarbital” (OR: 1.350; 95% CI: 1.064, 1.714; P = 0.014) and “CMV infection” (OR: 10.818; 95% CI: 0.915, 127.914; P = 0.059). Furthermore, “duration of phenobarbital” might independently delay the time to reach full enteral feeding (OR: 1.479; 95% CI: 1.088, 2.011; P = 0.013), causing parenteral nutrition associated cholestasis.Conclusion: This study found that duration of phenobarbital was associated with neonatal cholestasis in premature infants with hsPDA. Phenobarbital should be used cautiously in preterm infants with hsPDA or cholestasis.
The mediating effect of social support on the association between socioeconomic status and oral health among the migrant elderly following children in Weifang, China: a cross-sectional study
Authors: Pang Mingli , Wang Jieru , Tian Tingting , Zhao Jinfeng , Jiang Xiaoxu , Li Hexian , Kong Fanlei 
Published: May 2022

Abstract
Background
As an important part of the elderly population, the migrant elderly following children (MEFC) have received more and more attention in the background of active aging. The purpose of this study is to clarify the mediating effect of social support on the relationship between socioeconomic status (SES) and oral health among the MEFC in Weifang, China.
Methods
Multistage cluster random sampling was used to select the participants and finally 613 MEFC were included in the survey. The Social Support Rating Scale (SSRS) and the Chinese version of the Geriatric Oral Health Assessment Index (GOHAI) scale were used for data collection. Descriptive analysis, chi-square test, t-test and structural equation modeling (SEM) were conducted in this study.
Results
Mean score of GOHAI of the MEFC was 54.95 ± 6.47. The SES of MEFC exerted positive direct effect both on social support (standardized coefficient = 0.15) and oral health (standardized coefficient = 0.22); social support exerted positive direct effect on oral health (standardized coefficient = 0.17). Social support partially mediated the association between SES and oral health [95% confidence interval (CI): 0.003–0.064, P < 0.05], and the mediating effect of social support accounted for 12.0% of the total effect.
Conclusions
Higher GOHAI score of MEFC indicated their good oral health status. MEFCs’ SES could exert positive effect both on social support and oral health, while the moderating effect of social support between SES and oral health of MEFC was established. Targeted implication for the government, community and family members were proposed to improve the oral health of MEFC.
The FLURESP European Commission project: Cost-Effectiveness assessment of eight public health measures against influenza in Italy: is there an interest in COVID-19 pandemic?
Authors: Beresniak Ariel , Napoli Christian , Oxford John , Daruich Alejandra , MA Laurent Niddam , Duru Gérard , Tozzi Alberto E , Atti Marta Ciofi , Dupont Danielle , Bremond-Gignac Dominique , Rizzo Caterina 
Published: May 2022

Abstract
Background: The FLURESP project is a public health research funded by the European Commission, with the objective to design a methodological framework to assess and compare the cost-effectiveness of existing public health measures against human influenza pandemics in four target countries: France, Italy, Poland and Romania. This article presents the results relevant to the Italian health system using a dataset specifically collected for this purpose. As most of interventions against human influenza are relavant against other respiratory diseases pandemics, potential interests in COVID-19 are discussed.Methods: Eight public health measures against human influenza pandemics pandemic were selected to be also relevant to other respiratory virus pandemics such as COVID 19: 1) individual (hand washing, using masks), 2) border control (quarantine, fever screening, border closure), 3) community infection (school closure, class dismissal, social distancing, limitation of public transport), 4) reduction of secondary infections (implementation of antibiotic therapy guidelines), 5) pneumococcal vaccination for at-risk people, 6) development of Intensive Care Unit (ICU) capacity, 7) implementation of life support equipments in ICU and 8) screening interventions (virus testing).The outcome "achieving a mortality reduction of higher or equal to 40%” has been selected as a meaningful effectiveness criteria from the public health perspective. Cost distributions have been taken into account according to the Italian health system using a uniform distribution. Results: In the frame of the major pandemic event observed in Italy in 2020, the most cost-effective strategies are “reduction of secondary infections” and “implementation of life support equipment in ICU”. The least cost-effective option during a major pandemic event is screening interventions.Conclusions: A number of intervention strategies against human influenza pandemics appears relevant against respiratory virus pandemics in general such as the COVID-19 pandemic. These pandemics are imposing a substantial economic burden in Italy, confirming the interest of considering the cost-effectiveness of public health measures to enlighten decision making.
The impact of fetal programming in ewe nutrition with chromium propionate or calcium salts of palm oil on the meat quality and bone of the progeny
Authors: Brochine Luciano , Santos Fernanda Ferreira , Moreira Flávia Mallaco , Leme Paulo Roberto , Tedeschi Luis Orlindo , Gallo Sarita Bonagurio 
Published: May 2022

Abstract
This study aimed to evaluate the inclusion of chromium propionate or calcium salts of palm oil in ewes' diet in the final third of gestation and lactation on the effects of progeny performance, carcass characteristics, non-carcass components, and bone density. Forty-three ewe, Santa Inês and Dorper breeds, 3 ± 1 years old and weighing 57 ± 10 kg were used. The ewes were distributed in causal blocks in three treatments, CTL treatment (n = 15) with starch from corn; CR (n = 15) diet CTL plus chromium propionate; PF (n = 13) diet CTL plus calcium salts of palm oil. After weaning, 23 male lambs from these ewes were confined in individual stalls, with the same diet for 60 days, slaughtered. The data were analyzed using PROC GLM and means evaluated using the Tukey at 5%. Maternal diet did not alter the DMI, FE, and ADWG. Therefore, weaning and slaughter weights were higher for Cr and PF groups than CTL (P < 0.05). Carcass yield was also higher for these treatments (P < 0.05), but loin eye area and fat thickness were not influenced (P > 0.05) by diet regimen. The spleen and the respiratory tract were smaller for PF and larger for CTL (P < 0.05). The leg weight was about half of the carcass weight for the CR. The perimeter and depth of the shank for the CR and PF lambs were higher, indicating an effect of maternal nutrition in this commercial cut. The CR group had a smaller epiphysis measurement and femur length than the CTL group. We concluded that the fetal programming effect in ewes fed with Cr propionate and Ca salts of palm oil benefited the progeny by increasing their body weight, better carcass yield, and a higher proportion of prime cuts.
Transtendon technique versus repair after completion of the tear for articular-sided partial rotator cuff tear - a meta-analysis
Authors: Yang Yimeng , Hu Dan , Chen Shiyi , Guan Shibing , Shang Xiliang 
Published: May 2022

Abstract
Background
Partial-thickness rotator cuff tears (PT-RCTs) are a common cause of shoulder pain and disability. Arthroscopic repair is an effective treatment for articular-sided PT-RCTs, and transtendon repair and repair after completion of the tear have been widely used to treat such lesions. However, controversy continues with the best management. The present study was designed to compare the clinical outcomes and tendon integrity following arthroscopic repair of articular PT-RCTs using transtendon repair or repair after completion of the tear.
Methods
We performed a systematic electronic database search on Cochrane Central Register of Controlled Trials, PubMed and Embase to identify articles equating articular-sided PT-RCTs repair. The randomised controlled clinical trials that met our criteria were evaluated for quality of methodology. The results obtained were further analysed and correlated to present the benefits and drawbacks comparing the two surgical procedures.
Result
According to our inclusion and exclusion criteria, six articles were included in the present study. A total of 501 patients were analyzed as part of this study. The results indicated that both the surgical treatments provided excellent functional improvements and tendon integrity. However, no significant differences for the visual analogue scale (VAS) score, American Shoulder and Elbow Surgeons (ASES) score, constant score, range of motion, postoperative adhesive capsulitis, tendon integrity and patient satisfaction were found between the two cohorts (p > 0.05).
Conclusions
The study demonstrated technical characteristics of both repair techniques, contributing to make a decision under different clinical circumstance. Compared to transtendon technique, repair after completion of the tear has the advantage of simple operation and the removal of possible bursal degeneration tissue, and could be a convenient choice to degenerated articular-sided PT-RCTs.
Plasma metabolomic profiles reveal sex- and maturation-dependent metabolic strategies in sea lamprey (Petromyzon marinus)
Authors: Tamrakar Sonam , Huerta Belinda , Chung-Davidson Yu-Wen , Li Weiming 
Published: May 2022

Abstract
Introduction Adult sea lamprey (Petromyzon marinus) cease feeding and migrate to spawning streams where males build nests, undergo final sexual maturation, and subsequently produce and release large quantities of bile acid pheromones that attract mature females. These animals are predicted to rearrange their metabolic pathways drastically to support their reproductive strategies, presenting advantageous opportunities to examine how sex and the maturation processes affect metabolism.Objectives The objective is to investigate the metabolic differences between sexes and maturation states in sea lamprey that support changes in physiological functions.Methods We compared plasma metabolomes of spawning and prespawning sea lamprey in both sexes using both non-targeted and targeted metabolomics approaches using UPLC/MS-MS with electrospray ionization in both positive and negative modes. The data were processed using Progenesis QI, Compound Discoverer and XCMS softwares for alignment, peak picking, and deconvolution of the peaks. Principle component analyses (PCA) and partial least squares discriminant analyses (PLS-DA) were performed using SIMCA and Metaboanalyst softwares to identify discriminating features, followed by fragmentation matching with extensive database search and pathway mapping. Results The pheromonal bile acid biosynthesis was upregulated significantly in males compared to females. Spermiating males further upregulated bile acid biosynthesis by altering amino acid metabolisms, upregulating cofactors and nucleotide metabolisms, but downregulating carbohydrate and energy metabolisms. Conclusion Plasma metabolomes are sex- and maturation-dependent and reflect the special metabolic demands at each life stage and reproductive strategy.
The clinical outcomes and complications of combined fixation with cannulated screws and the modified Pyrford technique for the treatment of transverse patellar fractures: a case series study
Authors: Li Yihan , Tian Qingxian , Leng Kunpeng , Guo Meng 
Published: May 2022

Abstract
Background: Transverse patellar fractures can be fixed using various techniques. The purpose of the current study was to assess the clinical outcomes and complications rate of a combined fixation technique using cannulated screws and the modified Pyrford technique with non-absorbable polyester sutures. Methods and Patients: Between January 2015 and February 2021, 26 transverse patellar fractures were fixed with this combined technique. Pre-operative data were collected from patients with transverse patellar fractures and the patients were followed up for at least 12 months. At each follow-up visit, plain radiographs were taken. At the 12-month post-operative follow-up, range of motion of the affected knee joint and clinical outcomes, as evaluated by the Bostman scoring system, were recorded.Results: The average Bostman score at the 12-month post-operative follow-up was 28.3±1.5. Further, the average extension and flexion of the knee joint were 1.2±2.1 and 125.6±6.7 degrees, respectively. One patient experienced delayed bone union and one experienced superficial wound infection. There were no other post-operative complications. One patient required removal of the device for social-psychological reasons. Conclusions: The combined fixation technique with cannulated screws and the modified Pyrford technique with suture materials produced excellent clinical outcomes and a low rate of complications in the treatment of transverse patellar fractures.
Predictors of referral to specialised palliative care at a University Hospital: Towards purposeful commitment of a limited resource
Authors: Adamidis F. , Baumgartner N. , Kitta A. , Kum L. , Unseld M. , Marosi C. , kreye G. , Fischer C. , Zeilinger E.L , Masel E.K 
Published: May 2022

Abstract
Purpose
Palliative Care (PC) can be divided into general PC (GPC) as an integrated part of patient care in all fields of medicine and specialised PC (SPC), which is usually provided within palliative care units (PCUs) by specialised PC physicians. To date, the criteria on which patients are selected for SPC or GPC are not standardized. Such information would be vital for increasing the efficiency of the limited resource of SPC. The present study aims at identifying criteria associated with the referral to SPC in a large University hospital.
Methods
This retrospective single-centre study evaluated the total of 704 PC consultation requests between March 2016 and August 2020 to examine characteristics of patients who were referred to SPC at a PCU compared to those receiving GPC. To analyse criteria correlated with referral to PCU, binary logistic regression was conducted. Significant variables were then incorporated into a multivariate logistic regression model.
Results
The total of 704 PC consultation requests included 374 requests for a referral to SPC and 330 requests for a PC consultation, only. Of the 374 patients for whom the treating physician requested a referral to SPC, 145 (38.8%) patients were actually referred. Statistically significant factors associated with referral to SPC were the need for pain management (OR = 2.3) and nutritional advice (OR = 4.4).
Conclusion
Indicated triggers requiring SPC included complex symptom burdens, particularly pain and nutrition problems. Further education regarding these findings could help to ameliorate targeted use of the limited resource SPC.
Evaluation of a scale-up WHO SCC and mentoring based program for improving quality of intrapartum care in public sector in Rajasthan, India: repeated mixed-methods surveys
Authors: Singh Samiksha , Kannuri Nanda Kishore , Mishra Aparajita , Gaikwad Leena , Shukla Rajan , Tyagi Mukta , Chamarty Swecha 
Published: May 2022

Abstract
Background: Dakshata program in India aims to improve resources, providers’ competence and accountability in labour wards of public sector secondary care hospitals. It is based on the WHO Safe Childbirth Checklist coupled with mentoring. In Rajasthan state, an external technical partner trained, mentored and periodically assessed performance; identified local problems and supported solutions; supported state in monitoring. We (a third party) evaluated the effectiveness and factors contributing to success and sustainability.Methods: We conducted three repeat mixed-method surveys across 24 hospitals which were at different stage of program implementation when evaluation initiated: Group 1-trainings started and Group 2-one round of mentoring completed. We followed them over 18 months. Data was collected by directly observing obstetric assessments and childbirth, extracting information from casesheets and registers, and interviewing postnatal women. Theory-driven qualitative assessment included in-depth interviews with administrators, mentors, obstetric staff, and officers/mentors from external partner.Results: Average adherence to practices increased, saw a dip and then again improved. Significant improvement noted in several practices in the two groups—more in pause points 1, 2 and 3 but less in 4. Overall average adherence improved: Group 1, 55% to 72%; and Group 2, 69% to 79% (p<0.001). Stillbirth rate reduced: Group 1, 1.5/1,000 to 0.2; and Group 2, 2.5 to 1.1 (p<0.001). The mentoring with periodic assessments were highly acceptable, efficient means of capacity building, and ensured continuity in skills upgradation. Nurses felt empowered while involvement of doctors was low. The state health administration was highly committed and involved in program management; hospital administration supported. The competence, consistency and support from the technical partner were highly appreciated. Conclusion: Dakshata program was successful in improving resources and competencies. The program is sustainable and scalable. The states with low capacities will require intensive external support for a head start.