bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐Infrared‐Responded High Sensitivity Nanoprobe for Steady and Visualized Detection of Albumin in Hepatic Organoids and Mouse Liver
Authors: Liu Guofeng , Wei Jinsong , Li Xiaoyu , Tian Meng , Wang Zhenxing , Shen Congcong , Sun Wan , Li Chonghui , Li Xuewen , Lv Enguang , Tian Shizheng , Wang Jihua , Xu Shicai , Zhao Bing 
Published: July 2022

AbstractExploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near‐infrared light. In various bio‐samples, the UCNPs‐Ab‐RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL−1). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4‐induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.
Enabling Ultrathick Electrodes via a Microcasting Process for High Energy and Power Density Lithium‐Ion Batteries
Authors: Plateau Tazdik Patwary , Pham Hiep , Zhu Yaqi , Leu Ming , Park Jonghyun 
Published: July 2022

AbstractThickening electrodes is one effective approach to increase active material content for higher energy and low‐cost lithium‐ion batteries, but limits in charge transport and huge mechanical stress generation result in poor performance and eventual cell failure. This paper reports a new electrode fabrication process, referred to as µ‐casting, enabling ultrathick electrodes that address the trade‐off between specific capacity and areal/volumetric capacity. The proposed µ‐casting is based on a patterned blade, enabling facile fabrication of 3D electrode structures. The study reveals the governing properties of µ‐casted ultrathick electrodes and how this simultaneously improves battery energy/power performance. The process facilitates a short diffusion path structure that minimizes intercalation‐induced stress, improving energy density and cell stability. This work also investigates the issues with structural integrity, porosity, and paste rheology, and also analyzes mechanical properties due to external force. The µ‐casting enables an ultrathick electrode (≈280 µm) that more effectively utilizes NMC‐811 (LiNi0.8Mn0.1Co0.1O2) cathode and mesocarbon microbeads anode active materials compared to conventional thick electrodes, allowing high‐mass loading (35.7 mg cm−2), 40% higher specific capacity, and 30% higher areal capacity after 200 cycles, high C‐rate performance, and longer cycle life.
Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease
Authors: Liu Haotian , Xie Yong , Wang Xia , Abboud Martine I. , Ma Chao , Ge Wei , Schofield Christopher J. 
Published: July 2022

AbstractHypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients with cardiovascular disease are prone to Alzheimer's disease (AD). 2‐Oxoglutarate and ferrous iron‐dependent oxygenases (2OGDD) play a key role in the regulation of oxygen homeostasis by acting as hypoxia sensors. 2OGDD also have roles in collagen biosynthesis, lipid metabolism, nucleic acid repair, and the regulation of transcription and translation. Many biological processes in which the >60 human 2OGDD are involved are altered in AD patient brains, raising the question as to whether 2OGDD are involved in the transition from normal aging to AD. Here we give an overview of human 2OGDD and critically discuss their potential roles in AD, highlighting possible relationships with synapse dysfunction/loss. 2OGDD may regulate neuronal/glial differentiation through enzyme activity‐dependent mechanisms and modulation of their activity has potential to protect against synapse loss. Work linking 2OGDD and AD is at an early stage, especially from a therapeutic perspective; we suggest integrated pathology and in vitro discovery research to explore their roles in AD is merited. We hope to help enable long‐term research on the roles of 2OGDD and, more generally, oxygen/hypoxia in AD. We also suggest shorter term empirically guided clinical studies concerning the exploration of 2OGDD/oxygen modulators to help maintain synaptic viability are of interest for AD treatment.
Small‐Molecule Quenchers for Förster Resonance Energy Transfer: Structure, Mechanism, and Applications
Authors: Fang Bin , Shen Yu , Peng Bo , Bai Hua , Wang Limin , Zhang Jiaxin , Hu Wenbo , Fu Li , Zhang Wei , Li Lin , Huang Wei 
Published: July 2022

AbstractFor fluorogenic probes, Förster resonance energy transfer (FRET) is one of the most widely used mechanisms to realize the detection of biochemical activities. Dark quenchers relax from the excited state to the ground state non‐radiatively, and are promising alternatives to fluorescent FRET acceptors. Small‐molecule (dark) quenchers have been widely used as acceptors in FRET‐based probes to monitor various physiological processes with minimum background signal. Herein, we summarize the relevant advances of small‐molecule quenchers that are used in FRET‐based probes. This Review is intended to provide suggestions regarding the rationale design and selection of appropriate fluorophore–quencher FRET pairs, which are fully compatible with challenging analytical applications in various biological systems. Finally, an outlook of the future biomedical applications and developments of this field is presented.
Biokompatible und selektive Generierung bizyklischer Peptide**
Authors: Ullrich Sven , George Josemon , Coram Alexandra E. , Morewood Richard , Nitsche Christoph 
Published: July 2022

AbstractBizyklische Peptide sind aufgrund ihrer überragenden Eigenschaften für die Arzneimittelforschung von hoher Bedeutung. Ihre chemische Darstellung ist jedoch kompliziert und zudem häufig weder biokompatibel noch orthogonal zu allen kanonischen Aminosäuren. Die selektive Reaktion zwischen 1,2‐Aminothiolen und 2,6‐Dicyanpyridin ermöglicht die Synthese komplexer, bizyklischer Peptide in hoher Ausbeute. Mit Hilfe der etablierten Festphasenpeptidsynthese kann dieser Prozess vollständig automatisiert werden. Die Bizyklisierung ist katalysatorfrei und erfolgt bei physiologischem pH‐Wert in Wasser binnen Minuten. Verschiedene Bindeglieder ermöglichen die Herstellung maßgeschneiderter bizyklischer Peptide, die Vorzüge wie Plasmastabilität, strukturelle Vororganisation und hohe Zielstrukturaffinität aufweisen. Dies veranschaulichen wir anhand eines bizyklischen Hemmstoffs der Zikavirus‐Protease, sowie mit Hilfe bizyklischer Versionen des α‐helikalen, antimikrobiellen Peptids Aurein 1.2.
An Iron‐Catalyzed Route to Dewar 1,3,5‐Triphosphabenzene and Subsequent Reactivity
Authors: Barrett Adam N. , Diefenbach Martin , Mahon Mary F. , Krewald Vera , Webster Ruth L. 
Published: July 2022

AbstractThe application of an alkyne cyclotrimerization regime with an [Fe(salen)]2‐μ‐oxo (1) catalyst to triphenylmethylphosphaalkyne (2) yields gram‐scale quantities of 2,4,6‐tris(triphenylmethyl)‐Dewar‐1,3,5‐triphosphabenzene (3). Bulky lithium salt LiHMDS facilitates a rearrangement of 3 to the 1,3,5‐triphosphabenzene valence isomer (3′), which subsequently undergoes an intriguing phosphorus migration reaction to form the ring‐contracted species (3′′). Density functional theory calculations provide a plausible mechanism for this rearrangement. Given the stability of 3, a diverse array of unprecedented transformations was investigated. We report novel crystallographically characterized products of successful nucleophilic/electrophilic addition and protonation/oxidation reactions.
Adsorption application of Rb+ on hydrogels of hydroxypropyl cellulose/polyvinyl alcohol/reduced graphene oxide encapsulating potassium cobalt hexacyanoferrate
Authors: Fang Ming , Chu Wei‐fan , Cui Jingsi , Jin Guan‐Ping , Tian Changqing 
Published: July 2022

Specific ion exchangers/adsorbents are used to separate low concentration rubidium (Rb) resources from seawater or salt lakes, especially potassium cobalt hexacyanoferrate (KCoFC) with high adsorption capacity and selectivity for Rb+. However, there are great challenges in recovery from solution for powder form KCoFC. Herein, a new immobilization strategy was presented, and KCoFC was encapsulated by synthetic hydrogels of hydroxypropyl cellulose/polyvinyl alcohol/reduced graphene oxide (KCoFC‐HPR). Scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, and X‐ray photoelectron spectroscopy were employed to indicate the correct encapsulation of KCoFC. The adsorption behavior of KCoFC‐HPR for Rb+ was investigated, and the results demonstrated that the process conformed to pseudo‐second‐order kinetic model and Langmuir isotherm model with the exchange of Rb+ and K+ as main adsorption mechanism. The maximum adsorption capacity for Rb+ on KCoFC‐HPR achieved 211.2 mg g−1 at 25°C. The interference of lithium and sodium ions (Li+/Na+:Rb+ = 20:1) on the adsorption capacity proved negligible. Within 24 h, 77.9% of adsorbed Rb+ on KCoFC‐HPR in 0.5 mol L−1 NH4Cl/HCl mixture was desorbed, and adsorption capacity for the regenerated sample was 88.1% of the initial sample.
Continuous remeshing for inverse rendering
Authors: Palfinger Werner 
Published: July 2022

AbstractWe present a novel method for joint optimization and remeshing and apply it to inverse rendering. Rapid advances in differentiable rendering during the last years paved the way for fast inverse rendering of complex scenes. But serious problems with gradient‐based optimization of triangle meshes remain. Applying gradient steps to the vertices can lead to mesh defects, such as flipped triangles, crumpled regions, and self‐intersections. Choosing a good vertex count is crucial for the optimization quality and performance but is usually done by hand. Moreover, meshes with fixed triangulation struggle to adapt to complex geometry. Our novel method tackles all these problems by applying an adaptive remeshing step in each single iteration of the optimization loop. By immediately collapsing suspicious triangles, we avoid and heal mesh defects. We use a closed‐loop‐controlled location‐dependent edge length. We compare our solution to state‐of‐the‐art methods and find that it is faster and more accurate. It produces finer meshes with fewer defects, requires less parameter tuning and can reconstruct more complex objects.
Tailoring the Morphology and Performance of Polyacrylonitrile Ultrafiltration Membranes for Produced Water Treatment via Solvent Mixture Strategy
Authors: Naderi Noushin , Hosseini Seyed Saeid , Atassi Yomen 
Published: July 2022

AbstractThe separation performance of membranes is highly dependent on their morphology and microstructure. The present study aims to tailor the characteristics of asymmetric polyacrylonitrile (PAN) ultrafiltration membranes by adopting a solvent mixture strategy, combining dimethylformamide (DMF) and N‐methyl‐2‐pyrrolidone (NMP) for produced water treatment. The ternary phase diagram was used for better analysis of the microstructural changes from the thermodynamics point of view. Using a solvent mixture containing more DMF (i.e., 75 %) and increasing the PAN concentration in the dope were effective in improving the solution viscosity and promoting delayed demixing. As a result, finger‐like macrovoids were suppressed to some extent and the internal morphology of the membranes was transformed into a sponge‐like structure, accompanied by a reduction in the overall membrane porosity and mean pore size.
Flexible Electrode for Rapid Glucose Detection Based on CuO Nanoflowers/Stereo‐Graphene Coated on Carbon Cloth
Authors: Wang Xiao , Liu Qian , Qiu Xiaopei , Wang Yingran , Xu Hanqing , Liang Qingle , Wang Jun , Gao Mingxuan , Bao Jing , Chen Ming 
Published: July 2022

AbstractDesigning a highly sensitive, fast response, cheap, and flexible biosensing platform has important significance in the diagnosis of diabetes. Herein, we developed an ultra‐fast and sensitive glucose sensor based on CuO nanoflowers‐coated stereo‐graphene electrode on carbon cloth. The three‐dimensional graphene (3DG) nanostructures were established on the carbon cloth (CC) by radio frequency plasma enhanced chemical vapor deposition (RF‐PECVD), and CuO nanoflowers subsequently obtained via chemical deposition. The prepared CuO@3DG@CC electrode with self‐assembled structures provided abundant ion diffusion channels, large specific surface area and high conductivity, which shows an ultrasensitive current response to glucose. The detection limit of the sensor is as low as 0.068 μM and the response efficiency is as fast as 0.5 s. The electrode has two linear ranges with 0.5–115.5 μM and 165.5–1165.5 μM and has a strong anti‐interference ability and shows an excellent stability. This kind of flexible enzyme‐free glucose sensor has been successfully applied to the detection of glucose in actual serum samples and shows a good accuracy, which is likely be applied to the medical testing field and the commercial production and has potential to further applied in wearable sensors.
Indole‐Based Long‐Wavelength Fluorescent Probes for Bioimaging of S‐Nitrosylation in Mitochondria
Authors: Yu Jinfeng , Gan Lu , Zhou Yani , Xu Jingyao , Yun Chengyu , Fang Tong , Cai Xiaoqing 
Published: July 2022

AbstractS‐Nitrosylation has been found to play an important role in regulating mitochondrial function. However, probes for detection of protein S‐nitrosylation in mitochondria remain unexplored. Herein, a novel 4‐(pyridin‐4‐yl)vinyl‐substituted indole was designed, exhibiting a long‐wavelength emission and a high fluorescent quantum yield. Functionalization of the 7‐position of the indole ring with an arylphosphine ester resulted with probes with efficient mitochondria‐targeting ability. Furthermore, the indole‐arylphosphine displayed a significant fluorescence enhancement upon exposure to S‐nitrosoglutathione (GSNO) at low micromolar concentrations in A431 cells. Taken together, this study provides a new indole‐based fluorescent probe with a unique long‐wavelength emission for direct detection of S‐nitrosylation in mitochondria, which may represent a powerful tool for understanding the critical roles of S‐nitrosylation within mitochondria of living organisms.
Unravelling the Role of the Pentafluoroorthotellurate Group as a Ligand in Nickel Chemistry
Authors: Pérez‐Bitrián Alberto , Hoffmann Kurt F. , Krause Konstantin B. , Thiele Günther , Limberg Christian , Riedel Sebastian 
Published: July 2022

AbstractThe pentafluoroorthotellurate group (teflate, OTeF5) is able to form species, for which only the fluoride analogues are known. Despite nickel fluorides being widely investigated, nickel teflates have remained elusive for decades. By reaction of [NiCl4]2− and neat ClOTeF5, we have synthesized the homoleptic [Ni(OTeF5)4]2− anion, which presents a distorted tetrahedral structure, unlike the polymeric [NiF4]2−. This high‐spin complex has allowed the study of the electronic properties of the teflate group, which can be classified as a weak/medium‐field ligand, and therefore behaves as the fluoride analogue also in ligand‐field terms. The teflate ligands in [NEt4]2[Ni(OTeF5)4] are easily substituted, as shown by the formation of [Ni(NCMe)6][OTeF5]2 by dissolving it in acetonitrile. Nevertheless, careful reactions with other conventional ligands have enabled the crystallization of nickel teflate complexes with different coordination geometries, i.e. [NEt4]2[trans‐Ni(OEt2)2(OTeF5)4] or [NEt4][Ni(bpyMe2)(OTeF5)3].
Nanoarchitectonics in the Ionothermal Synthesis for Nucleation of Crystalline Potassium Poly (heptazine imide) Towards an Enhanced Solar‐Driven H2O2 Production
Authors: Yang Zhenchun , Li Lina , Cui Jiahao , Shao Siting , Zeng Shiqi , Wang Kun , Ma Dongge , Hu Chun , Zhao Yubao 
Published: July 2022

AbstractSolar‐driven selective oxygen reduction reaction on polymeric carbon nitride framework is one of the most promising approaches toward sustainable H2O2 production. Potassium poly(heptazine imide) (PHI), with regular metal sites in the framework and favorable crystalline structure, is highly active for photocatalytic selective 2e oxygen reduction to produce H2O2. By introducing NH4Cl into the eutectic KCl‐LiCl salt mixture, the PHI framework exhibits a remarkable performance for photocatalytic production of H2O2, for example, a record high H2O2 photo‐production rate of 29.5 μmol h−1 mg−1. The efficient photocatalytic performance is attributed to the favorable properties of the new PHI framework, such as improved porosity, negatively shifted LUMO position, enhanced exciton dissociation and charges migration properties. A mechanistic investigation by quenching and electron spin resonance technique reveals the critical role of superoxide radicals for the formation singlet oxygen, and the singlet oxygen is one of the critical intermediates towards the formation of the H2O2 by proton extraction from the ethanol.
Replacing executive stock options with share units: A Canadian study
Authors: Savoie‐Comeau Alexandre , Morris Tania M. 
Published: July 2022

AbstractAre share units a better compensation tool than stock options? This paper studies the impact of a transition within the compensation structures of CEOs of companies listed on the TSX Composite Index. Specifically, we ask whether replacing options with units‐based compensation reduces the volatility of these companies' stock prices while promoting better returns. Our findings show that a shift to share units reduces large‐cap Canadian companies' total risk through its idiosyncratic component. This transition is also accompanied by an increase in their risk‐adjusted accounting and market performance. This suggests that share units are better for compensation contracts.
Experiments with traditional and modern plasticizers
Authors: Bertsche Ingo 
Published: July 2022

AbstractIn diesem Beitrag werden zwei Methoden zum Nachweis von Phthalsäureestern (Phthalaten) und Citronensäureestern (Citraten) beschrieben. Die Wirkung von Weichmachern wird in einfachen Experimenten aufgezeigt.
Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab
Authors: Quah Gaik Tin , Blanchard Gillian , Miller Neil , Wilson Paul , Nordman Ina 
Published: July 2022

AbstractBackgroundIn malignancy, eosinophils have been shown to play an important role in the tumour micro‐environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune‐related adverse events. However, there are many other causes for developing eosinophilia which can contribute to the difficulties in diagnosis and management.CaseHere, we present a case of Strongyloides parasitic infection as an uncommon differential for eosinophilia in a patient with lung cancer receiving a PDL‐1 ICI, durvalumab, in Australia.ConclusionThis case highlights the complexities exploring the multiple potential causes of eosinophilia and the subsequent management, to allow safe continuation of ICI.
Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease
Authors: Shao Li , Shi Junping , Fan Xiaohui 
Published: July 2022

AbstractNon‐alcoholic fatty liver disease (NAFLD) with an increasing incidence is one of the leading causes for liver transplantation and cancer, whereas understandings on the onset and development of this disease are quite limited. Nowadays, gut microbial dysregulation has been proposed to play a critical role in the immune‐metabolic disorders in NAFLD patients via gut‐liver axis. Although definitive crosstalk between gut and liver has not been thoroughly depicted, the nanosized bacterial extracellular vesicles (bEVs) capable of transporting multiple kinds of molecules to distant organs of host in intact form via system circulation act as major mediators in host‐bacterial interactions. A recent review has confirmed the associations between bEVs and NAFLD features such as insulin resistance and liver inflammation, whereas the mechanisms involved have not been elucidated. Considering that gut‐liver crosstalk is the main pathway through which bEVs take part in NAFLD pathogenesis, we summarize the recent findings of bEVs in gut‐liver crosstalk by modulating the reshape of gut microbial system, host intestinal barrier integrity, host immune responses and metabolic homeostasis, as well as the potential roles of bEVs in regulating NAFLD progression.
Association of maternal and paternal psychosocial stress and infant hair cortisol among Arab American immigrants: A pilot study
Authors: Khalil Dalia , Giurgescu Carmen , Misra Dawn P. , Templin Thomas , Jenuwine Elizabeth 
Published: July 2022

AbstractAcculturative stress is unique among immigrants and refers to the stress associated with maintaining cultural values and traditions in the host country. Immigrant parents confront psychosocial variables such as acculturative stress, anxiety, and depression that might result in intergenerational negative consequences on their infants. Measurement of hair cortisol concentration (HCC), an outcome of neuroendocrine dysregulation, is one relatively noninvasive approach to gauge stress in infants. No published studies have evaluated associations among parents’ psychosocial variables and infants’ HCC among immigrant families. Therefore, the purpose of this study was to: (1) examine the relationship between maternal and paternal psychosocial stress variables; and (2) examine the association between psychosocial variables of both parents (acculturative stress, anxiety, and depression) and infants’ HCC among immigrant Arab American families. A sample of 31 immigrant Arab American triads (mother–father–infant) was recruited. During one home visit, each parent completed the study questionnaires separately when the baby was 6–24 months old and a hair sample was collected from the infant for HCC. Parents reported significant symptoms of anxiety (33% mothers; 45% fathers) and depression (33% mothers; 35.5% fathers). Paternal acculturative stress, anxiety, and depressive symptoms were significantly correlated to infants’ HCC. Acculturative stress, anxiety, and depressive symptoms were significantly correlated between mother–father dyads. Future research should continue to focus on immigrant families and include both parents to better understand and improve infant health.