bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPACT OF POSTURAL POSITION ON DETERMINATION OF AORTIC STIFFNESS AND CENTRAL BLOOD PRESSURE
Authors: Philibert Emy , Paré Mathilde , Côté Nadège , Fortier Catherine , Duval Karine , Goupil Rémi , Obeid Hasan , Agharazii Mohsen 
Published: June 2022

Objective:
Aortic stiffness is associated with increased central pulse pressure and cardiovascular disease and mortality. It is generally performed by determination of carotid-femoral pulse wave velocity (PWV) in a supine position. Two alternative approaches have been developed to estimate aortic stiffness, namely brachial pulse waveform analysis (Mobil-O-Graph) and finger-to-toe PWV by photoplethysmography (pOpmeter). These devices make it possible to assess and estimate aortic stiffness conveniently in different positions. However, it remains unclear if the values obtained are independent of the position at the time of measurement. Therefore, the aim of the present study is to determine the extent of postural changes on pulse wave velocity and central blood pressure estimation using pOpmetre and Mobil-O-Graph devices in a group of healthy controls.

Design and method:
Central blood pressure and PWV were assessed in 20 healthy subjects using both Mobil-O-Graph (PWV-M) and pOpmetre (PWV-pop) in three positions: supine position in bed, supine position in medical sampling chair and a sitting position. Central systolic blood pressure (SBP) was determined by calibration of brachial systolic and diastolic blood pressures (C1 calibration) by both methods (SBP-M and SBP-pop).

Results:
In the supine position in bed, PWV-M and PWV-pop were similar (5.5 ± 1.0 vs 5.4 ± 1.3 m/s, P = NS). In the supine position in a sampling chair, PWV-M decreased slightly (5.3 ± 1.0 m/s, P = 0.04 vs supine in bed), while PWV-pop increased significantly (5.9 ± 1.5 m/s, P = 0.04 vs supine in bed). However, in the sitting position, while PWV-M was not statistically different from the supine position (5.5 ± 1.0 m/s, P = NS), PWV-pop increased very significantly (9.2 ± 1.7 m/s, P < 0.001). Central blood pressure estimation remained similar for SBP-M (110.2 ± 10.3 vs 106.9 ± 10.5 vs 108.8 ± 11.1 mmHg, P = NS) and for SBP-pop (107.7 ± 10.4 vs 110.3 ± 9.6 vs 109.5 ± 9.9 mmHg, P = NS).

Conclusions:
These preliminary results tell us that postural position has little impact on the determination of aortic stiffness by the approach using brachial pulse wave analysis. However, finger-to-toe PWV increases remarkably with changes in position, possibly offering to explore the relationship between hydrostatic pressure and arterial stiffness as a dynamic test.
RISK FACTOR PROFILING OF ACUTE CORONARY SYNDROME IN PREMENOPAUSAL WOMEN PRESENTING AT A TERTIARY CARE HOSPITAL IN URBAN INDIAN SETTING: AN OBSERVATIONAL STUDY
Authors: Mishra Prashant , Karegowda Praveen , Amritkar Vijay 
Published: June 2022

Objective:
This study aimed to evaluate cardiovascular risk factors in premenopausal women presenting with acute coronary syndrome (ACS).

Design and method:
Premenopausal women presenting with ACS at the Deenanath Mangeshkar hospital & research center, Pune between January 2012 and June 2019 were enrolled. Data concerning demographics, risk factors and medical history (self-reported) were collected.

Results:
Ninety premenopausal women (mean age: 40.8 ± 5.0 years) were included in the study. The most common presenting symptoms were chest pain (83.3%) and shortness of breath. ACS presentation included ST-elevation myocardial infarction (38.9%), unstable angina (34.4%) and non-ST-elevation myocardial infarction (25.6%). Mild-to-severe left ventricular dysfunction was seen in 52.2% women and triple or double vessel disease in 52.2% women. The most frequent conventional coronary risk factors were diabetes (of total 41%, 48. 6% were poorly controlled) and hypertension (38.9%); lifestyle-related risk factor were low levels of physical activity (51.1%); and obstetric and gynaecological factors were history of at least one miscarriage (26.7%) and hormonal contraceptive use (26.7%). No correlation was found between the risk factors and presentation of ACS or severity of coronary artery disease.

Conclusions:
The high prevalence of conventional risk factors need to be identified and addressed early. Novel gynaecological risk factors are often ignored and need fair attention in routine practice in premenopausal women presenting with ACS. To our knowledge, this is one of the largest data set that determined cardiovascular risk factors in premenopausal women with ACS.
HYPERTENSION IN CAMEROONIAN RURAL AND URBAN PYGMIES AND BANTUS OF THE SOUTHERN REGION
Authors: Hako Yves , Bika Claude , Okala Cecile , Dissongo Jean Ii , M’buyamba Kabangu Jean-René , Degaute Jean Paul , Van De Borne Philippe , Lemogoum Daniel 
Published: June 2022

Objective:
To determine the prevalence of hypertension and associated risk factors among rural and urban pygmy and Bantu dwellers of southern Cameroon

Design and method:
In this cross-sectional cluster sampling survey, we examined 100 traditional pygmies (TP) living in equatorial forest in Kavabousse village under hunter-gatherer subsistence mode, 100 traditional Bantus (TB) living in Bidjouka village closed to Kavabousse (rural area); and 100 contemporary pygmies (CP) and 100 contemporary Bantus (CB) both living in the same urban environment in Kribi city. Trained observers recorded in each participant lifestyle and socio-demographic data, and clinical parameters. Brachial systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in triplicate using an automatic sphygmomanometer (Omron 705 CP). Hypertension was defined as SBP/DBP > or = 140/90 mmHg.

Results:
As compared to Bantus, Pygmies were younger (38 ± 16 vs 45 ± 17 years, p = 0.0001), with lower body mass index (22.7 ± 3.3 vs 24.9 ± 4.6, p < 0.0001). Age-adjusted SBP and DBP were lower in Pygmies than in Bantus (p < 0.0001), however within group SBP and DBP were similar among rural and urban individuals. Age-adjusted prevalence of hypertension was lower in pygmies than Bantus globally (7.5% vs 21.5% p = 0.0001), and in rural and urban areas: 4% vs 19% and 11% vs 24 %, respectively, both p < 0.01). In pygmies taken separately, the age-adjusted prevalence of hypertension was lower in TP than in CP (4% vs 11%). In the whole study population, multivariate logistic regression analysis revealed that hypertension was independently associated with urban area (OR = 2.15, 95%CI: 1.14–4.05), Bantu status (OR = 2.17, 95%CI: 1.09–4.34), age >or = 50 years (OR = 2.15, 95%CI: 1.14–4.05), and abdominal obesity (OR = 0.20 95%CI: 0.09–0.46) (all p < 0.05). In pygmies taken separately, multivariate logistic regression analysis shown that age >or = 50 years (OR = 3.83, CI95%: 1.33–11.36) and urban area (OR = 3.33, CI95%: 1.04–11.11) (both p < 0.05) were independent determinants of hypertension.

Conclusions:
This study reveals that hunter-gatherer lifestyle is associated with lower prevalence of hypertension as illustrated in TP. Hypertension is more common in Bantus and CP, and is largely attributable to their westernized lifestyle and the growing urbanization of rural area.
METABOLIC PHENOTYPE OF OBESITY IN YOUNG WOMEN AND THEIR DAILY BLOOD PRESSURE PROFILE
Authors: Evsevyeva Maria , Prokhorenko-Kolomoitseva Irina , Sergeeva Oksana , Gachkova Irina , Penzova Violetta , Ovchinnikova Olga 
Published: June 2022

Objective:
The prevalence of overweight (MT) and obesity among women is 59.2%. The expediency of singling out a group of patients with metabolically healthy obesity is being actively discussed.The ratio of obesity variants and hemodynamic status is still poorly studied, including of young women. These data are necessary to optimize the predictive diagnosis of diseases associated with various variants of obesity, and to improve their personalized prevention. to evaluate the effect of metabolic phenotype (MP) of obesity on the indicators of daily monitoring of blood pressure (DMBP).

Design and method:
The study included 100 women aged 18 to 35 years. The MP was determined by different combinations of such indicators as the body mass index (BMI) and the HOMA-Index (HI). In the 1st group, women with a BMI less 25 kg/m2 and HI less 2.52 (control), in the 2nd group with BMI less 25 kg/m2 and HI more 2,52, in the 3rd group BMI more 25 kg/m2 and HI less 2.52, in the 4th group BMI more 25 kg/m2 and HI more 2.52. DMBP indicators were evaluated using the BPLab Vasotens device (N-Novgorod, Russia).

Results:
In women in 4th group, compared with the control during the daytime, SBP increased by 16.8 mm Hg or 14.8% (P = 0.0000), DBP increased by 7.1 mm Hg or 9.4% (P = 0.0000). SBP is enlarged in midnight by 14.3 mmHg or 14.5% (P = 0.0000), DBP - by 5.0 mmHg or 8.0% (P = 0.0044). In women from the 2nd and 3rd groups, these indicators were higher than the control, but these differences were less pronounced.

Conclusions:
In young women, the maximum increase in SBP and DBP per day was detected when excessive BM/obesity was combined with high insulin resistance. Their presence in an isolated form is associated with less pronounced disorders of DMBP. It is useful to take these data into account when creating a system of predictive diagnostics of the consequences of obesity and their individualized prevention by more differentiated formation of cardiovascular risk groups among the discussed contingent, according to the metabolic status.
THE RELATIONSHIP BETWEEN THE MUSCLE MASS INDEX AND THE AGGREGATION OF CARDIOVASCULAR RISK FACTORS IN CHINESE ADOLESCENTS AGED 12–17 YEARS
Authors: Bai Ling , Zhou Jinyu , Tong Lingling , Ding Wenqing 
Published: June 2022

Objective:
The relationship between muscle mass and the aggregation of cardiovascular risk factors in adolescents is still controversial, therefore this study aimed to explore the relationship between muscle mass index (MMI) and the aggregation of cardiovascular risk factors (CVRFs) in adolescents.

Design and method:
A total of 1622 adolescents(1000 boys, 61.6%) aged 12–17 years from Ningxia were randomly selected through a stratified cluster sampling. we measured body composition by bioelectric impedance analysis (BIA), and calculated muscle mass index (MMI). The aggregation of cardiovascular risk factors is defined as the number of hypertension, abnormal fasting blood glucose, High total cholesterol (TC), High low-density lipoprotein cholesterol (LDL-C), Low high-density lipoprotein cholesterol (HDL-C), High triglyceride (TG).

Results:
MMI was a risk factor for the aggregation of cardiovascular risk factors (all P values < 0.001). After adjusting for age, gender and BMI, MMI became a protective factor for CVRFs>=1 (OR= 0.74, 95%CI: 0.62–0.89). In total population, the ORs for CVRFs> = 1 were 0.60 (95%CI: 0.46–0.79) in good MMI, 0.56 (95%CI:0.37–0.85) in sufficient MMI compared with insufficient MMI; The ORs for CVRFs> = 2 were 0.54 (95%CI: 0.37–0.79), 0.51 (95%CI: 0.30–0.87) respectively. Similar results were found in boys (all P values < 0.05).

Conclusions:
Muscle mass index as a protective factor for cardiovascular risk factor aggregation in adolescents with the same BMI level. Physical exercise of children and adolescents should be emphasized to maintain the best muscle mass and weight.
THE CARDIOVASCULAR HEALTH STATUS OF CARDIOLOGISTS IN CHINA: THE CHINA CARDIOLOGIST HEART STUDY
Authors: Yu Shikai , Zhang Yi , Peng Wenhui , Zhao Dong , Shi Hong , Zhang Shuning , Huo Yong , Xu Yawei , Ge Junbo 
Published: June 2022

Objective:
The morbidity and mortality of cardiovascular disease in China are still increasing. China cardiologists, as the gatekeeper of Chinese cardiovascular health, themselves should be healthy in cardiovasculature firstly, before they can take care of their patients. A national survey eligible to every China cardiologist was conducted to evaluate their health status and boost their perception on their own cardiovascular health.

Design and method:
An online questionnaire based on Wechat, a social application widely used in China, was tried to spread out to every cardiologist practicing in China. The information including age, gender, height, weight, life and work habits, cardiovascular risk factors, and histories of diseases and medication, were filled out by each surveyed cardiologist. Crude prevalences of cardiovascular risk factors, organ damage, and cardiovascular diseases were calculated and compared with data from Chinese general population.

Results:
A total of 17010 cardiologists (mean age 39 ± 9 years; 54.3% males) across China participated the survey between August 2020 and November 2021. Hyperlipidemia was the most common cardiovascular risk factor, followed by hypertension 2126 (12.5%), smoking 1232 (7.2%), overweight 1031 (6.1%), diabetes 404 (2.4%) and obesity 379 (2.2%). Compared with data from Chinese general population, cardiologists in China showed higher rates of awareness, treatment, and control rates of hypertension, diabetes, and hyperlipidemia. Male, versus female, cardiologists showed significantly higher prevalences of hypertension (18.6% vs 5.2%), diabetes (3.4% vs 1.2%), and hyperlipidemia (31.8% vs 18.1%). Intervention, versus non-intervention, cardiologists showed significantly higher prevalences of hypertension (15.6% vs 9.7%) and hyperlipidemia (30.8% vs 21.1%). Carotid plaque (3.5%) and microalbuminuria (1.3%) were the most prevalent subclinical organ damage. There were 539 (3.2%) cardiologists presented with arrhythmia, 378 (2.2%) with OSAS, and 82 (0.5%) with coronary artery disease.

Conclusions:
Compared to general population, China Cardiologists showed lower prevalences of hypertension, diabetes and hyperlipidemia and better management of cardiovascular risk. More attention and efforts are still needed to further improve the cardiovascular health of cardiologists in China, especially for males and intervention cardiologists.
PREVALENCE OF TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK FACTORS IN PATIENTS OF THE IBERICAN STUDY
Authors: Secin Anny Altagracia Romero , Gamarra Amelia González , Pérez Rafael Manuel Micó , Oria Virginia Lasso , Gil Ines Gil , Jelsbak Cristina Murillo , Royo Josefa Maria Panisello , Gómez González María José , Garcia Antonio Ruiz , Diaz Miguel Angel Prieto 
Published: June 2022

Objective:
The general aim of IBERICAN study is to know the prevalence and incidence of cardiovascular risk factors and cardiovascular and renal disease in Spain. The aim of this abstract is to know the prevalence of subclinical target organ damage (TOD) and cardiovascular risk in population of the IBERICAN Study.

Design and method:
The IBERICAN Study is a longitudinal, observational, and multicentric study with subjects between 18 to 85 years of age, recruited in Primary Care (PC) and who will be follow up at least 10 years. The final sample size is estimated in 8,066 patients. We show the baseline characteristics of the patients in the first visit (n = 8,066). To define the TOD, we consider the ESH 2013 Guide criteria: pressure pulse in aged > 60 mmHg, ankle/brachial index < 0.9, microalbuminuria: albumin/creatinine ratio (between 30 - 299 mg/g), glomerular filtration (CDK-EPI < 60 ml/min), left ventricular hypertrophy (electrocardiogram or ECHO).

Results:
2,052 patients presented TOD (25.4%). The most frequent cardiovascular risk in patients with TOD are: hypertension in 73.7% vs 39.1% p< 0.001, dyslipidemia in 65.3% vs 45.1% p < 0.001, obesity in 43% vs 32, 5% p < 0.001, type 2 diabetes mellitus (T2DM) in 35.2% vs 15% p < 0.001, sedentary lifestyle 66.2% vs 27.8% p = 0.2 and smoking in 11.1% vs 19.9% p < 0.001. Of the patients with TOD and hypertension had good control 46.4% vs 66.6% p < 0.001, TOD and T2DM 74.4% vs 66.2% p = 0.8, TOD and dyslipidemia 22.2% vs 30 .2% p < 0.001. 57% (n = 1,170) of the patients with TOD met the criteria for Metabolic Syndrome and 23.3% (n = 477) met premorbid metabolic syndrome.

Conclusions:
All cardiovascular risk factors were more frequent in patients with TOD, except for smoking. The most frequent cardiovascular rissk was hypertension arterial and the worst controlled was dyslipidemia. TOD classifies patients as having high cardiovascular risk, so being able to detect it in patients with one or more cardiovascular risk factor is relevant for the optimal therapeutic approach in primary prevention.
ASSOCIATION BETWEEN ARTERIAL STIFFNESS AND LEFT VENTRICULAR FUNCTION IN HYPERTENSIVE PATIENTS
Authors: Georgieva N. , Kinova E. , Borizanova A. , Shopov L. , Krastev B. , Ilieva R. , Goudev A. 
Published: June 2022

Objective:
Increased arterial stiffness is an early predictor of cardiovascular changes. However the association between arterial stiffness with LV myocardial changes is poorly understood
The aim of this study was to examine the relationship between arterial stiffness and LV function in well - controlled hypertensive patients.

Methods: A total 100 consecutive patients with hypertension adapted by age, gender and BMI, were separated in two groups: 27 patients with normal ventriculo - arterial coupling (VAC) and 63 hypertensive patients with disturbed VAC, measured by arterial elastance/ventricular elastance ratio(AE/Ees). All patients underwent standard two - dimentional (2D) echocardiography with Speckle tracking analysis for left ventricle (LV) global longitudinal strain (GLS). End - systolic pressure was determined from the brachial pulse wave. Arterial elastance (AE) and ventricular elastance (Ees) were calculated as and - systolic pressure/stroke volume and end - systolic pressure/end - systolic volume. Parameters for arterial stiffness - 24 - hour central systolic pressure (cSys24 h), central pulse pressure (cPP24 h), augmentation index 24 h (Aix24 h) and 24 - hour pulse wave velocity (PWV24 h) were measured non - invasively with oscillometric method by Mobil-O-graph PWA.

Results:
Statistically significant differences in parameters of vascular stiffness were found in patients with normal AE/Ees ratio in comparison disturbed AE/Ees: cSys24 h (108.76 ± 7.65 vs. 115.12 ± 11.58 mm Hg, p = 0.03), cPP24 h (39.61 ± 12.25 vs. 47.12 ± 11.52 mm Hg, p = 0.03). There is a statistically significant difference in echocardiography parameters between patients with normal VAC in comparison to other group: LV - GLS (-17.98 ± 0.65 vs. -15.9 ± 1.8 %, p = 0.0001), AE (2.09 ± 0.63 vs. 1.75 ± 0.34, p = 0.003), Ees (2.89 ± 0.71vs. 4.29 ± 0.72, p = 0.0001), AE/Ees ratio (0.74 ± 0.27 vs. 0.47 ± 0.46, p = 0.003). There were no statistically significant differences in LV ejection fraction, PWV24 h, Aix24 h and heart rate between two groups. There are moderately positive correlation between cSys24 h and LVMI (r = 0.325, p = 0.001) and negative with AE/Ees (r = -0.326, p = 0.01). cPP24 h correlate positively with AE (r = 0.249, p = 0.015) and negative with E/Em (r = -0.220, p = 0.032).

Conclusion:
Elevated arterial stiffness was intimately determines early LV alterations, before LV dysfunction, becomes clinically evident
CASE REPORT: HELLP-LIKE SYNDROME IN A 19-YEAR-OLD WOMAN WITH NOT WELL - CONTROLLED HYPERTENSION
Authors: Wojciechowska Ewa , Gryglas Piotr 
Published: June 2022

Objective:
We report a young woman with malignant hypertension (HTN) and multiorgan damage due to microangiopathy.

Design and method:
A 19-year old woman with previously recognized HTN and family history of HTN developed acute symptoms related to long-standing not well-controlled HTN. The patient presented with high blood pressure (BP), vomiting, epigastric pain, jaundice, impaired consciousness, tonic-clonic seizures, complete left eye blindness and partial right eye blindness. On admission, the patient was conscious but obtunded, with marked cognitive dysfunction, BP 255/143 mm Hg, heart rate 130 bpm, breathing rate 34/min, temperature 36,9C, SpO2 95%. Following admission, a transient loss of consciousness with eyes turning to the left was observed upon sitting up, without any arrhythmia seen in ECG monitoring. Neurological examination was unremarkable. Fundoscopy showed grade IV changes with papilledema, numerous hemorrhages and cotton wool spots.

Results:
Pregnancy test was negative. Laboratory test abnormalities included macrocytic anemia (Hb 10.25 g/dL, Hct 33.6%, MCV 103 fL), elevated leukocyte count (17.1x10 3 /L), low platelet count (69x10 3 /L), elevated serum bilirubin (10.4 mg/dL) and creatinine (4.2 mg/dL), and slightly elevated AspAT and troponin I. Brain CT showed chronic vascular brain damage. BP was gradually normalized using intravenous/oral antihypertensive drugs. Clinical symptoms and laboratory abnormalities resolved, except for left eye blindness and serum creatinine (2.47 mg/dL at discharge). Secondary HTN was excluded. The final diagnosis was malignant HTN, acute hypertensive encephalopathy with seizures, acute liver damage, chronic kidney disease, acute hemolytic anemia due to hypertensive microangiopathy, and permanent left eye blindness. Due to hemolysis and low platelet count, differential diagnosis included hemolytic-uremic syndrome which was excluded. The clinical presentation resembled that of HELLP syndrome in pregnant women with eclampsia, with evidence of target organ damage, low platelet count, liver and kidney dysfunction, and hemolytic jaundice.

Conclusions:
Young patients with essential HTN rarely present with such fulminant malignant HTN manifesting with neurological symptoms, with evidence of multiorgan damage due to microangiopathy. Similarly, microangiopathic hemolytic anemia rarely complicates malignant HTN. Initial clinical presentation was challenging due to neurological symptoms and evidence of multiorgan failure.
SERUM URIC ACID LEVELS APPEAR TO PREDICT IN-HOSPITAL MORTALITY IN PATIENTS ADMITTED WITH ACUTE ISCHEMIC STROKE
Authors: Tsankof Alexandra , Valanikas Evripidis , Papathanasiou Erofili , Polychronopoulos Georgios , Papadopoulos Anastasios , Tzavelas Marios , Satsoglou Sarantis , Veneti Stavroula , Ztriva Eleftheria , Tziomalos Konstantinos 
Published: June 2022

Objective:
Previous studies reported discrepant results regarding the association between serum uric acid levels and the outcome of acute ischemic stroke. We aimed to evaluate this association.

Design and method:
We prospectively studied 1,107 consecutive patients who were admitted for acute ischemic stroke (42.1% males, age 79.8 ± 7.2 years). Stroke outcome was evaluated with dependency at discharge (modified Rankin scale (mRS) at discharge 2–5) and with in-hospital mortality. Stroke severity was evaluated at admission with the National Institutes of Health Stroke Scale (NIHSS). Serum uric acid levels were measured at the second day after admission in the fasting state.

Results:
Serum uric acid levels did not correlate with the mRS at discharge (r = 0.003, p = NS) and did not differ between patients who were dependent at discharge and those who were independent (5.7 ± 1.9 and 5.8 ± 1.7 mg/dl, respectively; p = NS). Independent predictors of dependency were age (relative risk (RR) 1.075, 95% confidence interval (CI) 1.043–1.107, p < 0.001), history of ischemic stroke (RR 2.201, 95% CI 1.482–3.270, p < 0.001), family history of cardiovascular disease (RR 1.978, 95% CI 1.166–3.358, p < 0.05) and NIHSS at admission (RR 1.421, 95% CI 1.334–1.514, p < 0.001). Serum uric acid levels were higher in patients who died during hospitalization than in those who were discharged (6.2 ± 2.0 and 5.7 ± 1.9 mg/dl, respectively; p < 0.05). Independent predictors of in-hospital mortality were atrial fibrillation (RR 2.015, 95% CI 1.083–3.747, p < 0.05), diastolic blood pressure at admission (RR 1.046, 95% CI 1.024–1.068, p < 0.001) and NIHSS at admission (RR 1.188, 95% CI 1.148–1.231, p < 0.001).

Conclusions:
Elevated serum uric acid levels might be associated with higher in-hospital mortality in patients admitted with acute ischemic stroke.