bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of shell utilization and preference in two sipunculan genera, Phascolion and Aspidosiphon
Authors: Oshiro Kohei , Yoshikawa Akihiro , Asakura Akira , Goto Ryutaro 
Published: July 2022

AbstractSipunculans are non-segmented marine worms with an anterior retractable introvert, which are commonly included in Annelida based on molecular phylogenetic and phylogenomic analyses. They generally burrow in the soft sediments or live inside the crevices of hard substrata (e.g. calcareous/coralline rocks). However, members of some sipunculan genera (mainly Phascolion and Aspidosiphon) are known to have a peculiar habit of dwelling in vacant shells of gastropods or scaphopods. In this study, we investigated the shell utilization and preference pattern of the species of Phascolion and Aspidosiphon in Japan. We collected 302 sipunculans, comprising 273 and 29 individuals in Phascolion and Aspidosiphon, respectively, from 57–800 m depth of three study sites in the Pacific coast of Honshu Island, Japan. The species of Phascolion were found in vacant shells of 38 genera of 27 families of gastropods and six genera of four families of scaphopods, whereas the species of Aspidosiphon were found in 11 genera of 11 families of gastropods and one genus of scaphopod. These results suggest that members of each genus use a wide range of gastropod and scaphopod shells. The body size of the sipunculans was positively correlated with the shell size, suggesting that they change the shells as they grow. Furthermore, we investigated the shell preference of Phascolion species by comparing morphological characteristics of shells occupied and unoccupied by sipunculans. Generalized linear mixed model (GLMM) analyses suggest that the species of Phascolion tend to use long and narrow shells. Such shells likely fit well the elongated trunk of sipunculans.
Outcomes of repair of anomalous origin of pulmonary artery branch from aorta ascendens with autologous tissue: a rare condition revisited
Authors: Raja Javid , Menon Sabarinath , Ramanan Sowmya , Baruah Sudip Dutta , Gopalakrishnan Arun , Dharan Baiju 
Published: July 2022

AbstractBackground:Anomalous origin of pulmonary artery branch from ascending aorta (APA) in the presence of two separate semilunar valves is an uncommon entity necessitating early diagnosis and surgery to prevent development of irreversible pulmonary vascular disease. We evaluated our experience with the technique and outcome of 11 patients with this condition.Methods:Between January 2000 and December 2019, 11 patients were diagnosed with APA. Echocardiographic data were collected from the records, including the site of origin of the anomalous pulmonary artery, additional defects, pulmonary artery pressures, and biventricular function. Intraoperative charts were reviewed for the details of the surgical procedure and cardiopulmonary bypass. Post-operative data included survival, ventilatory support, and duration of hospital stay. After discharge, children were reviewed at 1 month, 3 months, 6 months, and then at yearly intervals.Results:Of the 11 patients, females were more than males (7:4) with a median age of 6 months (15 days–28 years) and median weight of 5.7 kg (1.8–40 kg). Nine patients underwent direct re-implantation of anomalous pulmonary artery branch to main pulmonary artery. The survival rate was 88.8% in our series. On follow-up, no re-operations or re-interventions were required and all surgically corrected patients were in stable clinical condition.Conclusion:Early- and midterm outcomes of children who underwent surgery for APA is convincing. Early direct re-implantation of the anomalous branch pulmonary artery to main pulmonary artery without any graft material is the optimal surgical strategy for these patients.
Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings
Authors: Hansell Narelle K. , Strike Lachlan T. , van Eijk Liza , O’Callaghan Victoria , Martin Nicholas G. , de Zubicaray Greig I. , Thompson Paul M. , McMahon Katie L. , Wright Margaret J. 
Published: July 2022

AbstractThe hippocampus is a complex brain structure with key roles in cognitive and emotional processing and with subregion abnormalities associated with a range of disorders and psychopathologies. Here we combine data from two large independent young adult twin/sibling cohorts to obtain the most accurate estimates to date of genetic covariation between hippocampal subfield volumes and the hippocampus as a single volume. The combined sample included 2148 individuals, comprising 1073 individuals from 627 families (mean age = 22.3 years) from the Queensland Twin IMaging (QTIM) Study, and 1075 individuals from 454 families (mean age = 28.8 years) from the Human Connectome Project (HCP). Hippocampal subfields were segmented using FreeSurfer version 6.0 (CA4 and dentate gyrus were phenotypically and genetically indistinguishable and were summed to a single volume). Multivariate twin modeling was conducted in OpenMx to decompose variance into genetic and environmental sources. Bivariate analyses of hippocampal formation and each subfield volume showed that 10%–72% of subfield genetic variance was independent of the hippocampal formation, with greatest specificity found for the smaller volumes; for example, CA2/3 with 42% of genetic variance being independent of the hippocampus; fissure (63%); fimbria (72%); hippocampus-amygdala transition area (41%); parasubiculum (62%). In terms of genetic influence, whole hippocampal volume is a good proxy for the largest hippocampal subfields, but a poor substitute for the smaller subfields. Additive genetic sources accounted for 49%–77% of total variance for each of the subfields in the combined sample multivariate analysis. In addition, the multivariate analyses were sufficiently powered to identify common environmental influences (replicated in QTIM and HCP for the molecular layer and CA4/dentate gyrus, and accounting for 7%–16% of total variance for 8 of 10 subfields in the combined sample). This provides the clearest indication yet from a twin study that factors such as home environment may influence hippocampal volumes (albeit, with caveats).
Unsaturated Transport Modeling: Random‐Walk Particle‐Tracking as a Numerical‐Dispersion Free and Efficient Alternative to Eulerian Methods
Authors: Henri Christopher V. , Diamantopoulos Efstathios 
Published: July 2022

AbstractLagrangian methods, such as the random‐walk particle‐tracking (RWPT), are often qualified as a potentially valuable alternative to error‐prone Eulerian methods for simulating solute transport in unsaturated porous media. Yet, the RWPT method has not yet been validated against ‐ and compared to ‐ currently used Eulerian solutions for simulating solute transport under a range of typical unsaturated conditions. This paper presents a new implementation of the RWPT approach for advective ‐ dispersive transport problems under variably saturated conditions. We first show that, as previously demonstrated for a heterogeneous dispersion tensor, using an interpolation scheme in the RWPT algorithm performs well for problems with abrupt changes in the water content. The new model is then compared against a simple 1D uniform transport problem, for which an analytical solution exist, and against a variety of 1D and 3D numerical solutions using the different Eulerian schemes implemented in Hydrus software suite. Results show that, while the Eulerian solutions significantly suffer from numerical dispersion in case of a coarse spatial discretization of the simulation domain, the new Lagrangian model provides accurate solutions for all problems. Furthermore, RWPT reproduces accurately solute transport for typical unsaturated flow conditions (infiltration, evaporation). Moreover, the Lagrangian model appears to be orders of magnitude faster than its Eulerian alternative to solve a 3D heterogeneous problem. Thus, RWPT should be seen as an attractive, stable and efficient alternative for simulating solute transport in the vadose zone, especially in case of complex and large problems.
The role of histone modifications: from neurodevelopment to neurodiseases
Authors: Park Jisu , Lee Kyubin , Kim Kyunghwan , Yi Sun-Ju 
Published: July 2022

AbstractEpigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation and organ development through spatial and temporal gene regulation. Neurogenesis is a sophisticated and complex process by which neural stem cells differentiate into specialized brain cell types at specific times and regions of the brain. A growing body of evidence suggests that epigenetic mechanisms, such as histone modifications, allow the fine-tuning and coordination of spatiotemporal gene expressions during neurogenesis. Aberrant histone modifications contribute to the development of neurodegenerative and neuropsychiatric diseases. Herein, recent progress in understanding histone modifications in regulating embryonic and adult neurogenesis is comprehensively reviewed. The histone modifications implicated in neurodegenerative and neuropsychiatric diseases are also covered, and future directions in this area are provided.
Calycosin prevents bone loss induced by hindlimb unloading
Authors: Jin Xiang , Wang Hong , Liang Xuechao , Ru Kang , Deng Xiaoni , Gao Shuo , Qiu Wuxia , Huai Ying , Zhang Jiaqi , Lai Linbin , Li Fan , Miao Zhiping , Zhang Wenjuan , Qian Airong 
Published: July 2022

AbstractBone loss induced by microgravity exposure seriously endangers the astronauts’ health, but its countermeasures still have certain limitations. The study aims to find potential protective drugs for the prevention of the microgravity-induced bone loss. Here, we utilized the network pharmacology approach to discover a natural compound calycosin by constructing the compound-target interaction network and analyzing the topological characteristics of the network. Furthermore, the hind limb unloading (HLU) rats’ model was conducted to investigate the potential effects of calycosin in the prevention of bone loss induced by microgravity. The results indicated that calycosin treatment group significantly increased the bone mineral density (BMD), ameliorated the microstructure of femoral trabecular bone, the thickness of cortical bone and the biomechanical properties of the bone in rats, compared that in the HLU group. The analysis of bone turnover markers in serum showed that both the bone formation markers and bone resorption markers decreased after calycosin treatment. Moreover, we found that bone remodeling-related cytokines in serum including IFN-γ, IL-6, IL-8, IL-12, IL-4, IL-10 and TNF-α were partly recovered after calycosin treatment compared with HLU group. In conclusion, calycosin partly recovered hind limb unloading-induced bone loss through the regulation of bone remodeling. These results provided the evidence that calycosin might play an important role in maintaining bone mass in HLU rats, indicating its promising application in the treatment of bone loss induced by microgravity.
Coherent interfaces govern direct transformation from graphite to diamond
Authors: Luo Kun , Liu Bing , Hu Wentao , Dong Xiao , Wang Yanbin , Huang Quan , Gao Yufei , Sun Lei , Zhao Zhisheng , Wu Yingju , Zhang Yang , Ma Mengdong , Zhou Xiang-Feng , He Julong , Yu Dongli , Liu Zhongyuan , Xu Bo , Tian Yongjun 
Published: July 2022

AbstractUnderstanding the direct transformation from graphite to diamond has been a long-standing challenge with great scientific and practical importance. Previously proposed transformation mechanisms1–3, based on traditional experimental observations that lacked atomistic resolution, cannot account for the complex nanostructures occurring at graphite−diamond interfaces during the transformation4,5. Here we report the identification of coherent graphite−diamond interfaces, which consist of four basic structural motifs, in partially transformed graphite samples recovered from static compression, using high-angle annular dark-field scanning transmission electron microscopy. These observations provide insight into possible pathways of the transformation. Theoretical calculations confirm that transformation through these coherent interfaces is energetically favoured compared with those through other paths previously proposed1–3. The graphite-to-diamond transformation is governed by the formation of nanoscale coherent interfaces (diamond nucleation), which, under static compression, advance to consume the remaining graphite (diamond growth). These results may also shed light on transformation mechanisms of other carbon materials and boron nitride under different synthetic conditions.
A synergistic mindsets intervention protects adolescents from stress
Authors: Yeager David S. , Bryan Christopher J. , Gross James J. , Murray Jared S. , Krettek Cobb Danielle , H. F. Santos Pedro , Gravelding Hannah , Johnson Meghann , Jamieson Jeremy P. 
Published: July 2022

AbstractSocial-evaluative stressors—experiences in which people feel they could be judged negatively—pose a major threat to adolescent mental health1–3and can cause young people to disengage from stressful pursuits, resulting in missed opportunities to acquire valuable skills. Here we show that replicable benefits for the stress responses of adolescents can be achieved with a short (around 30-min), scalable 'synergistic mindsets' intervention. This intervention, which is a self-administered online training module, synergistically targets both growth mindsets4(the idea that intelligence can be developed) and stress-can-be-enhancing mindsets5(the idea that one’s physiological stress response can fuel optimal performance). In six double-blind, randomized, controlled experiments that were conducted with secondary and post-secondary students in the United States, the synergistic mindsets intervention improved stress-related cognitions (study 1,n = 2,717; study 2,n = 755), cardiovascular reactivity (study 3,n = 160; study 4,n = 200), daily cortisol levels (study 5,n = 118 students,n = 1,213 observations), psychological well-being (studies 4 and 5), academic success (study 5) and anxiety symptoms during the 2020 COVID-19 lockdowns (study 6,n = 341). Heterogeneity analyses (studies 3, 5 and 6) and a four-cell experiment (study 4) showed that the benefits of the intervention depended on addressing both mindsets—growth and stress—synergistically. Confidence in these conclusions comes from a conservative, Bayesian machine-learning statistical method for detecting heterogeneous effects6. Thus, our research has identified a treatment for adolescent stress that could, in principle, be scaled nationally at low cost.
Systematic review of mental health symptom changes by sex or gender in early-COVID-19 compared to pre-pandemic
Authors: Dal Santo Tiffany , Sun Ying , Wu Yin , He Chen , Wang Yutong , Jiang Xiaowen , Li Kexin , Bonardi Olivia , Krishnan Ankur , Boruff Jill T. , Rice Danielle B. , Markham Sarah , Levis Brooke , Azar Marleine , Neupane Dipika , Tasleem Amina , Yao Anneke , Thombs-Vite Ian , Agic Branka , Fahim Christine , Martin Michael S. , Sockalingam Sanjeev , Turecki Gustavo , Benedetti Andrea , Thombs Brett D. 
Published: July 2022

AbstractWomen and gender-diverse individuals have faced disproportionate socioeconomic burden during COVID-19. There have been reports of greater negative mental health changes compared to men based on cross-sectional research that has not accounted for pre-COVID-19 differences. We compared mental health changes from pre-COVID-19 to during COVID-19 by sex or gender. MEDLINE (Ovid), PsycINFO (Ovid), CINAHL (EBSCO), EMBASE (Ovid), Web of Science Core Collection: Citation Indexes, China National Knowledge Infrastructure, Wanfang, medRxiv (preprints), and Open Science Framework Preprints (preprint server aggregator) were searched to August 30, 2021. Eligible studies included mental health symptom change data by sex or gender. 12 studies (10 unique cohorts) were included, all of which reported dichotomized sex or gender data. 9 cohorts reported results from March to June 2020, and 2 of these also reported on September or November to December 2020. One cohort included data pre-November 2020 data but did not provide dates. Continuous symptom change differences were not statistically significant for depression (standardized mean difference [SMD] = 0.12, 95% CI -0.09–0.33; 4 studies, 4,475 participants; I2 = 69.0%) and stress (SMD = − 0.10, 95% CI -0.21–0.01; 4 studies, 1,533 participants; I2 = 0.0%), but anxiety (SMD = 0.15, 95% CI 0.07–0.22; 4 studies, 4,344 participants; I2 = 3.0%) and general mental health (SMD = 0.15, 95% CI 0.12–0.18; 3 studies, 15,692 participants; I2 = 0.0%) worsened more among females/women than males/men. There were no significant differences in changes in proportions above cut-offs: anxiety (difference = − 0.05, 95% CI − 0.20–0.11; 1 study, 217 participants), depression (difference = 0.12, 95% CI -0.03–0.28; 1 study, 217 participants), general mental health (difference = − 0.03, 95% CI − 0.09–0.04; 3 studies, 18,985 participants; I2 = 94.0%), stress (difference = 0.04, 95% CI − 0.10–0.17; 1 study, 217 participants). Mental health outcomes did not differ or were worse by small amounts among women than men during early COVID-19.
Human pointing motion during interaction with an autonomous blimp
Authors: Hou Mengxue , Tao Qiuyang , Zhang Fumin 
Published: July 2022

AbstractWe investigate the interaction between a human and a miniature autonomous blimp using a wand as pointing device. The wand movement generated by the human is followed by the blimp through a tracking controller. The Vector Integration to Endpoint (VITE) model, previously applied to human–computer interface (HCI), has been applied to model the human generated wand movement when interacting with the blimp. We show that the closed-loop human–blimp dynamics are exponentially stable. Similar to HCI using computer mouse, overshoot motion of the blimp has been observed. The VITE model can be viewed as a special reset controller used by the human to generate wand movements that effectively reduce the overshoot of blimp motion. Moreover, we have observed undershoot motion of the blimp due to its inertia. The asymptotic stability of the human–blimp dynamics is beneficial towards tolerating the undershoot motion of the blimp.
REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats
Authors: Henningfield Jack , Gauvin David , Bifari Francesco , Fant Reginald , Shram Megan , Buchhalter August , Ashworth Judy , Lanier Ryan , Pappagallo Marco , Inturrisi Charles , Folli Franco , Traversa Sergio , Manfredi Paolo L. 
Published: July 2022

AbstractREL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert central nervous system activity, full characterization of its abuse potential is warranted. We evaluated lack of reinforcing effect, physical dependence, and withdrawal of REL-1017 in Sprague Dawley rats. (1) Self-administration Study Rats were trained to self-administer oxycodone intravenously (IV) and then were subjected to 3-day substitution tests where saline, oxycodone, and REL-1017 were self-delivered IV by a fixed number of lever presses; (2) Drug Discontinuation Study Rats were treated for 30 days by oral gavage with vehicle, REL-1017, ketamine or morphine and evaluated for withdrawal with functional observational batteries (FOBs). In the self-administration study, rats treated with saline, vehicle, and all REL-1017 doses showed the typical “extinction burst” pattern of response, characterized by an initial rapid increase of lever-pressing followed by a rapid decrease over 3 days. Rats treated with oxycodone maintained stable self-injection, as expected for reinforcing stimuli. In the withdrawal study, REL-1017 did not engender either morphine or ketamine withdrawal signs over 9 days following abrupt discontinuation of drug exposure. REL-1017 showed no evidence of abuse potential and did not engender withdrawal symptomatology.
New land tenure fences are still cropping up in the Greater Mara
Authors: Løvschal Mette , Juul Nørmark Maria , Svenning Jens-Christian , Wall Jake 
Published: July 2022

AbstractExpanding and intensifying anthropogenic land use is one of the greatest drivers of changes of biodiversity loss and political inequality worldwide. In the Greater Mara, Kenya, a trend of private land enclosure is currently happening, led by smallholders wishing to protect and uphold their land titles. Here we expand on previous work by Løvschal et al. quantifying the rapid, large-scale development of fencing infrastructure that began in 1985 but has increased by 170% from 2010 onwards. We provide fine-scale analysis of the spatial and temporal trends in fencing using high-resolution Sentinel-2 imagery. The formally unprotected regions have distinctly more fences than the rest of the Mara, one experiencing a 740% increase in fenced land in four years. Conservancies have an effect in stemming fencing but fences crop up within and along conservancy boundaries. We estimate the actual geographical coverage of the fences in the Mara to be 130,277 ha (19% of the total region) using an error margin of 8%, derived by calibrating our satellite mapping with ground-truth data. The study suggests the need for revising community-based eco-conservation efforts and pursuing a richer understanding of the socio-political and historical dynamics underlying this phenomenon.
The metabolic profile of reconstituting T-cells, NK-cells, and monocytes following autologous stem cell transplantation and its impact on outcome
Authors: Richter Silja , Böttcher Martin , Völkl Simon , Mackensen Andreas , Ullrich Evelyn , Jacobs Benedikt , Mougiakakos Dimitrios 
Published: July 2022

AbstractPrevious studies indicated a role of the reconstituting immune system for disease outcome upon high-dose chemotherapy (HDCT) and autologous stem cell transplantation (auto-SCT) in multiple myeloma (MM) and lymphoma patients. Since immune cell metabolism and function are closely interconnected, we used flow-cytometry techniques to analyze key components and functions of the metabolic machinery in reconstituting immune cells upon HDCT/auto-SCT. We observed increased proliferative activity and an upregulation of the glycolytic and fatty acid oxidation (FAO) machinery in immune cells during engraftment. Metabolic activation was more pronounced in T-cells of advanced differentiation stages, in CD56bright NK-cells, and CD14++CD16+ intermediate monocytes. Next, we investigated a potential correlation between the immune cells’ metabolic profile and early progression or relapse in lymphoma patients within the first twelve months following auto-SCT. Here, persistently increased metabolic parameters correlated with a rather poor disease course. Taken together, reconstituting immune cells display an upregulated bioenergetic machinery following auto-SCT. Interestingly, a persistently enhanced metabolic immune cell phenotype correlated with reduced PFS. However, it remains to be elucidated, if the clinical data can be confirmed within a larger set of patients and if residual malignant cells not detected by conventional means possibly caused the metabolic activation.