bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Long-term Oncologic Prognosis With Minimal Access Breast Surgery vs Conventional Breast Surgery
Authors: Wan Andi , Liang Yan , Chen Li , Wang Shushu , Shi Qiyun , Yan Wenting , Cao Xiaozhen , Zhong Ling , Fan Linjun , Tang Peng , Zhang Guozhi , Xiong Siyi , Wang Cheng , Zeng Zhen , Wu Xiujuan , Jiang Jun , Qi Xiaowei , Zhang Yi 
Published: October 2022

ImportanceMinimal access breast surgery (MABS) has been used in breast cancer management. However, long-term prognostic data associated with MABS vs conventional breast surgery (CBS) are lacking.ObjectiveTo investigate long-term therapeutic outcomes associated with MABS vs CBS for breast cancer management.Design, Setting, and ParticipantsIn this single-center retrospective cohort study, 9184 individuals were assessed for inclusion. After exclusions, 2412 adult female individuals were included who were diagnosed with stage 0 to III breast cancer, underwent unilateral breast surgery between January 2004 and December 2017, and had no distant metastasis or history of severe underlying disease. Propensity score matching was performed to minimize selection bias. Data were analyzed from January 1, 2004, to December 31, 2019.ExposuresMABS or CBS.Main Outcomes and MeasuresData on demographic and tumor characteristics and long-term outcomes were collected and analyzed.ResultsThis study included 2412 patients (100% female; median [IQR] age, 44 [40-49] years). Of these, 603 patients underwent MABS (endoscopic, endoscopy-assisted, or robot-assisted procedures in 289, 302, and 12 patients, respectively) and 1809 patients underwent CBS. The median follow-up time was 84 months (93 in the MABS group and 80 months in the CBS group). Intergroup differences were not significant for the following parameters: 10-year local recurrence-free survival (93.3% vs 96.3%; hazard ratio [HR], 1.39; 95% CI, 0.86-2.27; P = .18), regional recurrence-free survival (95.5% vs 96.7%; HR, 1.38; 95% CI, 0.81-2.36; P = .23), and distant metastasis-free survival (81.0% vs 82.0%; HR, 0.95; 95% CI, 0.74-1.23; P = .72). The 5-, 10-, and 15-year disease-free survival rates in the MABS group were 85.9%, 72.6%, and 69.1%, respectively. The corresponding rates in the CBS group were 85.0%, 76.6%, and 70.7%. The intergroup differences were not significant (HR, 1.07; 95% CI, 0.86-1.31; P = .55). The 5-, 10-, and 15-year overall survival rates in the MABS group were 92.0%, 83.7%, and 83.0%, respectively. The corresponding rates in the CBS group were 93.6%, 88.7%, and 81.0%. The intergroup differences were not significant (HR, 1.29; 95% CI, 0.97-1.72; P = .09). Post hoc subgroup analysis showed no significant intergroup differences in disease-free survival.Conclusions and RelevanceIn this cohort study, long-term outcomes following MABS were not significantly different from those following CBS in patients with early-stage breast cancer. MABS may be a safe and feasible alternative in this patient population.
Association of cardiorespiratory fitness with the risk factors of cardiovascular disease: Evaluation using the Japan step test from the National Institute of Occupational Safety and Health
Authors: So Rina , Murai Fumiko , Matsuo Tomoaki 
Published: October 2022

Abstract

Objective
Cardiorespiratory fitness (CRF) is an important factor for evaluating cardiovascular disease (CVD) risk. We recently developed a novel method (National Institute of Occupational Safety and Health, Japan step test [JST]) for evaluating CRF in workers; its criterion validity has been investigated. However, its association with health risk must be confirmed before its application in the workplace. Therefore, we aimed to determine the association of JST-evaluated CRF with the prevalence of CVD risk among Japanese workers.

Methods
For CRF evaluation, working adults completed the JST, which comprised a 3-minute stepping exercise and a 2-minute recovery period. Data on CVD risk factors and clinical history were collected through medical certification within 1 year from the date of the JST measurements. Participants were divided into three groups for multiple logistic regression analyses based on the JST values (low, moderate, and high). Odds ratios (ORs) for the prevalence of CVD risk were calculated.

Results
We recruited 885 working adults (46.4% women). The prevalence of CVD risk in the total population was 18.6%. When compared to the reference group (low CRF), the ORs for CVD risk prevalence after adjustments for lifestyle factors (smoking status, alcohol consumption status, and exercise habits) were 0.42 (95% confidence interval [CI], 0.28–0.63) and 0.29 (95% CI, 0.18–0.45) for the moderate and high groups, respectively.

Conclusion
An inverse association was noted between the JST-evaluated CRF and CVD risk prevalence. JST may be helpful for identifying workers at risk for CVD development.
Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface
Authors: Vermunt Lisa , Otte Marco , Verberk Inge M. W. , Killestein Joep , Lemstra Afina W. , van der Flier Wiesje M. , Pijnenburg Yolande A. L. , Vijverberg Everard G. B. , Bouwman Femke H. , Gravesteijn Gido , van de Berg Wilma D. J. , Scheltens Philip , van Harten Argonde C. , Willemse Eline A. J. , Teunissen Charlotte E. 
Published: October 2022

AbstractInterpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19–85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https://mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age‐dependent biomarkers in neurology.
Strukturaufklärung, Totalsynthese, In‐Vivo‐Aktivität und Potentieller Biosyntheseweg des Neuen Myxobakteriellen Antibiotikums Corramycin**
Authors: Couturier Cédric , Groß Sebastian , von Tesmar Alexander , Hoffmann Judith , Deckarm Selina , Fievet Anouchka , Dubarry Nelly , Taillier Thomas , Pöverlein Christoph , Stump Heike , Kurz Michael , Toti Luigi , Haag Richter Sabine , Schummer Dietmar , Sizun Philippe , Hoffmann Michael , Prasad Awal Ram , Zaburannyi Nestor , Harmrolfs Kirsten , Wink Joachim , Lessoud Emilie , Vermat Thierry , Cazals Veronique , Silve Sandra , Bauer Armin , Mourez Michael , Fraisse Laurent , Leroi‐Geissler Corinne , Rey Astrid , Versluys Stéphanie , Bacqué Eric , Müller Rolf , Renard Stephane 
Published: October 2022

AbstractIm Folgenden beschreiben wir das aus dem Myxobakterium Corallococcus coralloides isolierte Antibiotikum Corramycin. Die lineare Peptidstruktur enthält eine bislang unbeschriebene (2R,3S)‐γ‐N‐Methyl‐β‐hydroxyhistidin‐Einheit. Corramycin weist eine anti‐Gram‐negative Aktivität gegen Escherichia coli (E. coli) auf und wird über zwei Tansportersysteme, SbmA und YejABEF, in die Zelle aufgenommen. Darüber hinaus wurde das Corramycin Biosynthese‐Gencluster (BGC) identifiziert und ein Biosyntheseweg bestimmt, welcher auf einer 12‐modularen nicht‐ribosomale Peptidsynthetase/Polyketidsynthase beruht. Die bioinformatische Analyse des BGC in Verbindung mit der Entwicklung einer Totalsynthese ermöglichte die Aufklärung der absoluten Konfiguration des Moleküls. Außerdem führte die intravenöse Verabreichung von 20–30 mg Corramycin pro kg Mausgewicht in einem E. coli‐Infektionsmodell zu einer 100 %igen Überlebensrate der Tiere ohne toxische Nebenwirkungen. Somit ist Corramycin ein vielversprechender Ausgangspunkt für die Entwicklung eines wirksamen antibakteriellen Arzneimittels gegen Krankenhausinfektionen.
Sustainable Design of Structural and Functional Polymers for a Circular Economy
Authors: von Vacano Bernhard , Mangold Hannah , Vandermeulen Guido W. M. , Battagliarin Glauco , Hofmann Maximilian , Bean Jessica , Künkel Andreas 
Published: October 2022

AbstractTo achieve a sustainable circular economy, polymer production must start transitioning to recycled and biobased feedstock and accomplish CO2 emission neutrality. This is not only true for structural polymers, such as in packaging or engineering applications, but also for functional polymers in liquid formulations, such as adhesives, lubricants, thickeners or dispersants. At their end of life, polymers must be either collected and recycled via a technical pathway, or be biodegradable if they are not collectable. Advances in polymer chemistry and applications, aided by computational material science, open the way to addressing these issues comprehensively by designing for recyclability and biodegradability. This Review explores how scientific progress, together with emerging regulatory frameworks, societal expectations and economic boundary conditions, paint pathways for the transformation towards a circular economy of polymers.
Multi‐copolymerization retouch butadiene styrene block polymer resin for dual temperature change curing of wood‐based interface
Authors: Cong Riyao , He Xiangning , Zhao Shuangliang , Gao Wei , Li Hong , Liang Shaojun , Liu Ming , Zhang Jianhui 
Published: October 2022

AbstractCarboxylated styrene‐butadiene latex (XSBL), attributed to its insufficient adhesion and poor water resistance, cannot be widely popularized in the adhesive industry. Herein, a novel XSBL‐based resin with high‐strength yet water‐resistant was reported, in which the butadiene macromolecular chains were grafted with acrylonitrile (AN) and acrylic acid‐2 hydroxyethyl ester (HEA) molecules, the crosslinking sites were esterified and expanded to construct a branched network structure, and the matrix was filled with nano‐SiO2 particles treated by blending silane coupling agents. We show that the new resin, having a dual curing mechanism at low and high temperatures, can be glued under different conditions. At room temperature, the sample group with a doping level of 1.33 wt% could achieve an overload shear strength of 3.17 MPa after curing, which is 233.7% higher than the XSBL; in the high temperature curing regime, the glue strength reached 1.21 MPa, much higher than the standard for the use of GB Class I plywood (≥0.7 MPa). The physicochemical properties meet the requirements for potential industrialization, for which the property–structure relation has been extensively explored. Further DSC and TG tests provide evidence for their wide application in the hot pressing process of man‐made plywood.
Service performance of GF/Nano‐Al2O3/PA66 sucker rod centralizer in aqueous environment
Authors: Yan Yanhong , Yang Chengwen , Yan Pengjuan , Wang Peilong , Dong Wenbin , Jia Zhining 
Published: October 2022

AbstractSixteen groups of GF/Nano‐Al2O3/PA66 composite samples were prepared by injection molding process and orthogonal experimental design method. The water absorption, hardness, compressive strength, and tribological properties under water conditions were measured. The wear surface morphology and material transfer from mate pair were analyzed by scanning electron microscopy (SEM) and energy spectroscopy (EDS). The results show that the minimum friction coefficient of G25A1 ratio is 0.064, which is 54.3% and 72.2% lower than the two common used sucker rod centralizer materials, respectively; the wear rate of G20A7 is the minimum 7.46 × 10−5 mm3 (N m)−1, 63.6% and 19.9% lower than the two commonly used sucker rod centralizer materials, respectively; the water absorption, hardness and compression strength properties of 16 groups were improved; PA66 matrix composites with the best ratio of 20% GF and 7% Al2O3 were selected in this paper; the wear mechanism of the composite is fatigue wear and a little adhesive wear at moderate additive content, and it is easy to form a transfer film on the mating surface.
Psychic reality articulation in nonmainstream body modifications: A single‐case study
Authors: Londoño Diego E. , Gil Luisa F. , Marín Laura D. 
Published: October 2022

AbstractNonmainstream body modifications appear as a social and psychological phenomenon that has been explored from many angles: as identity construction, self‐ownership vindication or masking of mental distress. The purpose of this research is to approach this issue, implicating psychic reality constitution and the peculiar way a subject performing these modifications links the three registers of reality according to Lacan: the Real, the Symbolic and the Imaginary. A qualitative research on a single case was carried out, based on in‐depth interviews. The participant has performed multiple extreme body modifications within a transformation project he calls: “alien cyborg”. They include, tattoos, mutilations, and suspensions, among others. The interviews delivered several themes related to the three main categories corresponding to the Lacanian registers. The themes reveal the way the subject lives the body's jouissances and how he deals with them standing on each register. The body project as nomination of an unrepresentable inconsistency of the body and pain control, “normalcy” and “perfectionism” as main signifiers sustaining the whole chain, and a reshaping of the body image that can be sustained by the Other's gaze. The project raises as a means of building a specific connection with reality and projecting his body in a space where there seems to be no limitations.
Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet
Authors: Valdes Jennifer , Gagné‐Sansfaçon Jessica , Reyes Vilcy , Armas Anny , Marrero Gisela , Moyo‐Muamba Mitterrand , Ramanathan Sheela , Perreault Nathalie , Ilangumaran Subburaj , Rivard Nathalie , Fortier Louis‐Charles , Menendez Alfredo 
Published: October 2022

AbstractThe effect of Western diets in the gastrointestinal system is largely mediated by their ability to promote alterations in the immunity and physiology of the intestinal epithelium, and to affect the composition of the commensal microbiota. To investigate the response of the colonic epithelium to high‐fat/high‐cholesterol diets (HFHCDs), we evaluated the synthesis of host defense factors involved in the maintenance of the colonic homeostasis. C57BL/6 mice were fed an HFHCD for 3 weeks and their colons were evaluated for histopathology, gene expression, and microbiota composition. In addition, intestinal permeability and susceptibility to Citrobacter rodentium were also studied. HFHCD caused colonic hyperplasia, loss of goblet cells, thinning of the mucus layer, moderate changes in the composition of the intestinal microbiota, and an increase in intestinal permeability. Gene expression analyses revealed significant drops in the transcript levels of Muc1, Muc2, Agr2, Atoh1, Spdef, Ang4, Camp, Tff3, Dmbt1, Fcgbp, Saa3, and Retnlb. The goblet cell granules of HFHCD‐fed mice were devoid of Relmβ and Tff3, indicating defective production of those two factors critical for intestinal epithelial defense and homeostasis. In correspondence with these defects, colonic bacteria were in close contact with, and invading the epithelium. Fecal shedding of C. rodentium showed an increased bacterial burden in HFHCD‐fed animals accompanied by increased epithelial damage. Collectively, our results show that HFHCD perturbs the synthesis of colonic host defense factors, which associate with alterations in the commensal microbiota, the integrity of the intestinal barrier, and the host's susceptibility to enteric infections.
Resilience, and positive parenting in parents of children with syndromic autism and intellectual disability. Evidence from the impact of the COVID‐19 pandemic on family's quality of life and parent–child relationships
Authors: Bolbocean Corneliu , Rhidenour Kayla B. , McCormack Maria , Suter Bernhard , Holder Jimmy Lloyd 
Published: October 2022

AbstractFamily quality of life (FQoL) outcomes collected during the first year of COVID‐19 has been combined with 2018 data to estimate the outbreak's impact on parental outcomes on a sample of 230 families with syndromic autistic children and those with intellectual disabilities (IDs). Despite challenges imposed by the COVID‐19 outbreak, our study found that FQoL outcomes reported by participating parents during the first year of COVID‐19 appears to be similar to ratings from a prepandemic study of families with the same conditions. Parents of children in our sample generally displayed a stable functioning trajectory as measured by the validated FQoL instrument. Across syndromic autistic groups considered, families reported that their relationships with their children were positive. Our findings provide evidence of families' resilience which might explain the presence of positive parent–child interactions during COVID‐19. Exploring mechanisms which would explain how families with autistic and ID children confront, manage disruptive experiences, and buffer COVID‐19 induced stress is a fruitful direction for future research.
Synthesis of β,γ‐unsaturated ketones with quaternary centers through regioselective hydroacylation of allenes with acyl chlorides
Authors: Yoon Subin , Lee Kyeongmin , Kamranifard Telma , Lee Yunmi 
Published: October 2022

AbstractThe one‐pot synthesis of β,γ‐unsaturated ketones bearing all‐carbon quaternary centers at the α‐position via a highly regioselective hydroacylation of allenes using acyl chlorides and aluminum hydride is reported. The Cu‐catalyzed hydroalumination of 1,1‐disubstituted and 1,1,3‐trisubstituted allenes with diisobutylaluminum hydride resulted in allylaluminum reagents that underwent regioselective acylation in the presence of acid chlorides. Various derivatives of allenes and acyl chlorides were compatible with this process, and α‐quaternary ketones were obtained in high yields with excellent regioselectivity.
A medium‐weight deep convolutional neural network‐based approach for onset epileptic seizures classification in EEG signals
Authors: Nemati Nazanin , Meshgini Saeed 
Published: October 2022

AbstractIntroductionEpileptic condition can be detected in EEG data seconds before it occurs, according to evidence. To overcome the related long‐term mortality and morbidity from epileptic seizures, it is critical to make an initial diagnosis, uncover underlying causes, and avoid applicable risk factors. Progress in diagnosing onset epileptic seizures can ensure that seizures and destroyed damages are detectable at the time of manifestation. Previous seizure detection models had problems with the presence of multiple features, the lack of an appropriate signal descriptor, and the time‐consuming analysis, all of which led to uncertainty and different interpretations. Deep learning has recently made tremendous progress in categorizing and detecting epilepsy.MethodThis work proposes an effective classification strategy in response to these issues. The discrete wavelet transform (DWT) is used to breakdown the EEG signal, and a deep convolutional neural network (DCNN) is used to diagnose epileptic seizures in the first phase. Using a medium‐weight DCNN (mw‐DCNN) architecture, we use a preprocess phase to improve the decision‐maker method. The proposed approach was tested on the CHEG‐MIT Scalp EEG database's collected EEG signals.ResultThe results of the studies reveal that the mw‐DCNN algorithm produces proper classification results under various conditions. To solve the uncertainty challenge, K‐fold cross‐validation was used to assess the algorithm's repeatability at the test level, and the accuracies were evaluated in the range of 99%–100%.ConclusionThe suggested structure can assist medical specialistsin analyzing epileptic seizures' EEG signals more precisely.
Isolation and Reactivity of Stannylenoids Stabilized by Amido/Imino Ligands
Authors: Zhao Xuan‐Xuan , Fujimori Shiori , Kelly John A. , Inoue Shigeyoshi 
Published: October 2022

AbstractThe reaction of the lithium aryl(silyl)amide Dipp(iPr3Si)NLi (Dipp=2,6‐iPr2C6H3) with one equivalent of SnCl2 in THF gave a novel stannylenoid Dipp(iPr3Si)NSnCl⋅LiCl(THF)2. Heating the solution of amidostannylenoid in toluene to 80 °C resulted in dimeric amido(chloro)stannylene [Dipp(iPr3Si)NSnCl]2, which can be converted to bis(amido)stannylene Sn[N(Dipp)(iPr3Si)]2 and amido(imino)stannylene Sn[N(Dipp)(iPr3Si)][IPrN] (IPrN=bis(2,6‐diisopropylphenyl)imidazolin‐2‐imino). Treatment of bis(imino)stannylenoid [IPrN]2Sn(Cl)Li with N2O resulted in the dimeric complex [IPrNSn(Cl)OLi]2. All compounds were characterized by NMR, elementary analysis, and X‐ray structural determination.
Synthesis of Vinylene‐Linked Thiopyrylium‐, Pyrylium‐, and Pyridinium‐Based Covalent Organic Frameworks by Acid‐Catalyzed Aldol Condensation
Authors: Ji Haifeng , Yan Gaojie , Zou Peng , Wang Han , Li Mengke , Feng Yi , Qu Xiongwei , Geng Dongling , Shi Jingjing , Zhang Xiaojie 
Published: October 2022

AbstractThe development of new vinylene‐linked covalent organic frameworks (COFs) with special ionic structure and high stability is challenging. Herein, we report a facile, general method for constructing ionic vinylene‐linked thiopyrylium‐based COFs from 2,4,6‐trimethylpyrylium tetrafluoroborate and other common reagents by means of acid‐catalyzed Aldol condensation. Besides, pyrylium‐, and pyridinium‐based COFs also can be prepared from the same monomer under slightly different reaction conditions. The COFs exhibited uniform nanofibrous morphologies with excellent crystallinities, special ionic structures, well‐defined nanochannels, and high specific surface areas.
Transition‐Metal‐Free Dehydropolymerization of Phosphine–Boranes at Ambient Temperature
Authors: Wiebe Matthew A. , Kundu Subrata , LaPierre Etienne A. , Patrick Brian O. , Manners Ian 
Published: October 2022

AbstractStoichiometric reaction of phosphine–borane adducts RR'PH⋅BH3 (R=Ph, R’=H, Ph, Et, and R=R’=tBu) with the strong acid HNTf2 (Tf=SO2CF3) leads to H2 elimination and the formation of the triflimido derivatives, RR'PH⋅BH2(NTf2). Subsequent deprotonation by using bases, such as diisopropylethylamine or the carbene IPr (IPr=N,N’‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene), led to the formation of P‐mono‐ or ‐disubstituted polyphosphinoboranes [RR'P‐BH2]n. Evidence for the intermediacy of transient phosphinoborane monomers, RR'PBH2, was provided by trapping reactions.