bluuebunny/crossref_metadata_2025_split huggingface dataset:
493 Increased Utilization of Healthcare Services in Children with Craniosynostosis
Authors: Colon Gabriela R. , Jin Michael C. , Grant Gerald A. , Prolo Laura M. 
Published: March 2022

INTRODUCTION:
Craniosynostosis is a condition characterized by the premature fusion of at least one cranial suture. While evidence suggests that both syndromic and nonsyndromic patients may benefit from developmental, behavioral, and mental health support, data on utilization of healthcare services is lacking.

METHODS:
The Optum Clinformatics® DataMart database was queried to identify 1340 patients with craniosynostosis. Long-term utilization of mental health care, rehabilitation therapies, and other medical services up to age six was calculated. Rates of utilization were compared to healthy controls (n = 1577) and children with plagiocephaly (n = 1249).

RESULTS:
Mental health care was utilized more frequently in craniosynostosis patients (8.1%) compared to plagiocephaly (5.0%, p=0.0020) and healthy controls (2.9%, p<0.0001) . Physical, occupational and speech therapy were more frequently used by plagiocephaly than craniosynostosis patients (14.1% vs. 11.2%, p = 0.0283), which was significantly higher than use by controls (11.2% vs. 3.9%, p<0.0001). Other medical subspecialty services (developmental pediatrics, ophthalmology, optometry and audiology) were utilized by 37.0% of craniosynostosis patients, compared with 20.9% (p<0.0001) and 15.1% (p<0.0001) of plagiocephaly and healthy controls, respectively. Among craniosynostosis patients, utilization was not uniform by age; while ophthalmology utilization did not differ by age (p = 0.1003), mental health care was most commonly used among older children (p = 0.0107).

CONCLUSION:
In this study, we demonstrate that children with craniosynostosis utilize mental health care, rehabilitation therapies, and other medical subspecialty services at a higher rate than controls. While surgical correction may be considered an isolated event, these children should be monitored for developmental and mental health support longitudinally. Future work should explore risk factors driving utilization, including suture involvement, repair type, and comorbidities.
496 Stereotactic Electroencephalography is Associated with Reduced Opioid and NSAID Use When Compared to Subdural Grids: A Pediatric Case Series
Authors: Hunsaker Josh , Scoville Jonathan , Joyce Evan , Reese Jared C. , Wilde Herschel , Arain Amir , Bollo Robert J. , Rolston John D. 
Published: March 2022

INTRODUCTION:
Opioid administration and consumption along with length of hospital stay can be decreased using minimally invasive surgery (MIS).

METHODS:
A retrospective chart review was conducted on pediatric patients that underwent surgery for epilepsy mapping using either SEEG or ECoG between 2015-2019. The hospital stay was divided into four distinct time periods and the total amount of opioids, NSAIDs, and pain scores were calculated for each time interval. The total amount of opioids were calculated by converting each type into their morphine equivalents (ME). Pain scores were calculated by using a modified version of the Clinically Aligned Pain Assessment (CAPA) scale. The two groups were then compared using appropriate statistical tests.

RESULTS:
The study included 40 patients including 31 in the SEEG group and 9 in the ECoG group. The SEEG group consumed significantly less opioids during the hospital stay when compared to the ECoG group (23.6 vs 61.7 MMEs; p=0.041). There were also significant differences in the length of stay (6.9 vs 12.2 days; p=0.002), complications (0% vs 20%; p=0.006), and total NSAIDs consumed (3264.8 vs 12730.2 mg; p=0.002).

CONCLUSION:
Opioid and NSAID consumption are significantly lower in pediatric patients who undergo epilepsy mapping via SEEG compared to ECoG. These patients also have a significantly shorter length of stay. MIS options should be considered by patients and physicians in order to decrease the overall use of pain medications and expedite patient discharge.
Juego de tronos de los murciélagos. Myotis: la conquista de los nichos
Authors: Segura-Trujillo Cintya A. , Iñiguez-Dávalos Luis Ignacio 
Published: March 2022

Myotis es un género ancestral de murciélagos, que agrupa un gran número de especies aparentemente muy parecidas. No obstante, su historia evolutiva señala una variación morfológica enfocada en especializarse para conquistar diferentes nichos (roles ecológicos). La historia evolutiva de Myotis es antigua y compleja con la cual, para desenmarañarla, podemos hacer una analogía con la serie televisiva “Juego de tronos”.
Effectiveness of acupuncture therapy for preventing emergence agitation in children: A protocol for systematic review and meta-analysis with trial sequential analysis
Authors: Nakajima Daisuke , Mihara Takahiro , Hijikata Toshiyuki , Tomita Makoto , Goto Takahisa 
Published: March 2022

Pain, autonomic distress, and emergence agitation occur commonly in children undergoing general anesthesia. While acupuncture therapy has been reported to effectively reduce such pain and autonomic distress in children, its effect in preventing emergence agitation remains unclear. Therefore, we will conduct a systematic review and meta-analysis with trial sequential analysis to evaluate the effect of acupuncture therapy in preventing emergence agitation in children undergoing general anesthesia. Methods and analysis This protocol was prepared according to the 2015 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for Protocols guidelines. We will conduct a search for randomized controlled trials that evaluated the effect of acupuncture therapy in preventing emergence agitation. The following databases will be searched for relevant articles: MEDLINE, CENTRAL, Embase, and Web of Science; four pre-registration sites will be accessed from inception to April 1, 2021. No language restrictions will be applied. Two authors will independently scan and select eligible studies, extract the data, and assess the risk of bias. The incidence of emergence agitation will be combined as a risk ratio with a 95% confidence interval using a random-effect model. The I2 statistics will be used to assess heterogeneity. We will evaluate the quality of the clinical trials using the Cochrane methodology and assess the quality of evidence using the Grading of Recommendation Assessment, Development, and Evaluation approach. If appropriate, a trial sequential analysis will be performed. Expected outcomes This meta-analysis will be the first to evaluate the effect of acupuncture therapy in preventing emergence agitation in children. The findings from this meta-analysis have the potential to reveal pivotal factors that affect the clinical effect of acupuncture therapy, thereby supporting the optimization of acupuncture therapy for emergence agitation.
Protocol registration University Hospital Medical Information Network Clinical Trials Registry (UMIN000040775).
Magnitude and factors associated with appropriate complementary feeding practice among mothers of children 6–23 months age in Shashemene town, Oromia- Ethiopia: Community based cross sectional study
Authors: Ahmed Junayde Abdurahmen , Sadeta Kebede Kumsa , Lenbo Kelil Hussein 
Published: March 2022

Background
Inadequate complementary feeding is a major cause of childhood malnutrition. Malnutrition caused by insufficient complementary feeding accounts for more than one-third of all under-five mortality whereas appropriate feeding practices are critical for improving nutritional status and ensuring child survival. Thus, the objective of this study was to assess the prevalence of appropriate complementary feeding practices among mothers having 6–23 months children, from Feb.-march 2020 and associated factors in Shashemene Town, Oromia, Ethiopia.

Methods
From February to March of 2020, a community-based cross-sectional survey was conducted. 536 mothers with children aged 6 to 23 months were chosen for the study using a two-stage sampling procedure. Data was collected by Face-to-face interviews during home-to-home visits with mothers who had children aged 6–23 months, using a structured questionnaire on the main complementary feeding indicators. The Statistical Package for the Social Sciences (SPSS) software was used to analyze the data. Logistic regression was used to identify factors associated with appropriate complementary feeding practice, with statistical significance set at probability value < 0.05.

Results
The proportion of children aged 6–23 months who met the criteria for complementary food introduction, minimum meal frequency, minimum dietary diversity, minimum acceptable diet, and appropriate complementary feeding practices was 67.9 percent, 61.7 percent, 42.5 percent, 41.7 percent, and 30 percent, respectively. Child age 12–17 and 18–23 months were the independent factors associated with appropriate complementary feed practice [adjusted odd ratio (AOR): 2.32, 95 percent confidence interval (CI): (1.40–3.82)]. ** 1.91 (1.10–3.32) **. Socioeconomic status: mothers in the wealth index of the household, second, third, and fourth, [AOR: 4.27,95 percent, CI (1.8–10.22) ** 4.02(2.23–9.94) ** 7.02(3.27–15.1) **], number of antenatal care visits greater than or equal to four [AOR: 2.57,95 percent, CI: (1.3–5.05)] **, information sources [AOR: 3.5,95 percent, CI: (1.45–8.26) **].

Conclusion
This study found that children aged 6–23 months had a low level of appropriate complementary feeding practice. Mothers with children aged 6–11 months, the number of antenatal care (ANC) visits, socioeconomic status, sources of information, mothers’ knowledge, and positive attitude were all associated with appropriate feeding practices. As a result, nutritional education/counseling intervention on child feeding practices was suggested.
Untangling population structure and genetic diversity of reticulocyte binding protein 2b (PvRBP2b) erythrocytic stage vaccine candidate in worldwide Plasmodium vivax isolates
Authors: Nourani Leila , Abouie Mehrizi Akram , Zakeri Sedigheh , Djadid Navid Dinparast 
Published: March 2022

BackgroundsPlasmodium vivaxis the predominantPlasmodiumspecies distributed extensively in the Americas and Asia-Pacific areas. Encoded protein byPlasmodium vivaxReticulocyte Binding Proteins (PvRBPs) family member are of critical prominence to parasite invasion and have been considered the significant targets in development of malaria vaccine for the blood stage. As high genetic polymorphism of parasites may impede the effectiveness of vaccine development, more research to unraveling genetic polymorphism ofpvrbp2bfrom various geographical regions seems indispensable to map the exact pattern of field isolates.Methodology/Principal findingsThe aim of this study was to determine the sequences of Iranianpvrbp2b(nt: 502–1896) gene and then, to ascertain polymorphism ofpvrbp2bgene, recombination, the level of genetic distances, evaluation of natural selection, and the prediction of B-cell epitopes of Iranian and globalP.vivaxisolates.Pvrbp2bpartial gene was amplified and sequenced from 60 IranianP.vivaxisolates. Iranianpvrbp2bsequences as well as 95 published sequences from five countries were used to evaluate the genetic diversity and neutral evolution signature in worldwide scale. A total of 38 SNPs were identified among 60 Iranianpvrbp2bsequences (32 non-synonymous and 6 synonymous mutations), and 32 amino acid substitutions were observed in 29 positions as compared to Sal-1 sequence. Worldwide sequence analysis showed that 44 amino acid changes had occurred in 37 positions of which seven polymorphic sites had trimorphic mutations while the rest was dimorphic. The overall nucleotide diversity for Iranian isolates was 0.00431 ± 0.00091 while the level of nucleotide diversity was ranged from 0.00337 ± 0.00076 (Peru) to 0.00452 ± 0.00092 (Thailand) in global scale.Conclusions/SignificanceOf amino acid substitutions, 12 replacements were located in the B-cell epitopes in which nine polymorphic sites were positioned in N-terminal and three polymorphic sites in predicted B-cell epitopes of C-terminal, signifying both variable and conserved epitopes for vaccine designing. Using the achieved outcome of the current investigation interrogate questions to the selection of conserved regions ofpvrbp2band understanding polymorphism and immune system pressure to pave a way for developing a vaccine based on PvRBP2b candidate antigen.
O DIREITO À BUSCA DA FELICIDADE DOS EMPREGADOS INSERIDOS EM ORGANIZAÇÕES DE TENDÊNCIA CONFESSIONAIS
Authors: Machado Prigol Natalia Munhoz , Villatore Marco Antônio César 
Published: March 2022

Contextualização do tema: organizações de Tendências são entidades criadas com o objetivo de exteriorizar uma ideologia à sociedade, a exemplo das igrejas. O conceito jurídico implica no elastecimento do poder diretivo do empregador, o qual passa a poder exigir um comportamento de determinados empregados, dentro e fora do ambiente de trabalho, em consonância com a ideologia pregada, sob o argumento de proteger a imagem moral e a credibilidade da empregadora. Objetivos: objetiva-se com a pesquisa analisar se a aplicação deste conceito violaria o direito à felicidade originalmente disposto na Declaração de Independência norte-americana e, se afirmativo, qual deveria ser a postura do Estado? Metodologia: para responder ao problema proposto se utiliza do método dedutivo, sendo a pesquisa dividida em três capítulos, respectivamente: (i) análise do direito à felicidade, cuja construção teórica leva a conclusão de ser sinônimo de liberdade; (ii) estudo do conceito Organizações de Tendência e consequências decorrentes de sua aplicação nas relações de emprego; (iii) exame do papel do Estado na proteção do direito à felicidade daqueles empregados inseridos em Organizações de Tendência.Resultados: conclui-se que o conceito restringe o direito à felicidade de empregados diretamente vinculados à atividade fim da organização, mas não impõe ao Estado um dever positivo de intervenção; pelo contrário, implica um dever de abstenção, prevalecendo a liberdade da empregadora de ditar as normas da organização.
SOCIAL RIGHTS THROUGH TAX EXPENDITURES: CONTROL, EFFICIENCY AND EQUALITY ISSUES
Authors: Menezes Breyner Frederico 
Published: March 2022

Contextualização do tema: the main topic of this paper is the use of tax law as a tool to promote social rights by way of tax expenditures rules. Objetivos: the objective is to analyze, through doctrinal and institutional legal research, whether these issues imply disapproval or recommendation of the use of tax law for this purpose. Metodologia: the method of the tax expenditure analysis allows to link tax law and social rights by relating tax breaks and public expenditures. Considering that the main dimension of social rights corresponds to a positive duty to provide goods and services to guarantee social welfare, the use of tax expenditures to fulfill this duty poses challenges in terms of efficiency, control, and equality.Resultados: the result is that that these challenges do not always point at tax expenditures as a poor tool to promote social rights. The argument of this paper is that the merits of tax expenditures depend on its design by legislators considering the adopted tax base (direct taxation on income or indirect taxation on consumption) and on the presence of other mechanisms to ensure tax equality.
Declining Colectomy Rates for Nonmalignant Colorectal Polyps in a Large, Ethnically Diverse, Community-Based Population
Authors: Alam Asim , Ma Christopher , Jiang Sheng-Fang , Jensen Christopher D. , Webb Kenneth H. , Boparai Eshandeep S. , Jue Terry L. , Munroe Craig A. , Gupta Suraj , Fox Jeffrey , Hamerski Christopher M. , Velayos Fernando S. , Corley Douglas A. , Lee Jeffrey K. 
Published: March 2022

INTRODUCTION:
Despite studies showing improved safety, efficacy, and cost-effectiveness of endoscopic resection for nonmalignant colorectal polyps, colectomy rates for nonmalignant colorectal polyps have been increasing in the United States and Europe. Given this alarming trend, we aimed to investigate whether colectomy rates for nonmalignant colorectal polyps are increasing or declining in a large, integrated, community-based healthcare system with access to advanced endoscopic resection procedures.

METHODS:
We identified all individuals aged 50–85 years who underwent a colonoscopy between 2008 and 2018 and were diagnosed with a nonmalignant colorectal polyp(s) at the Kaiser Permanente Northern California integrated healthcare system. Among these individuals, we identified those who underwent a colectomy for nonmalignant colorectal polyps within 12 months after the colonoscopy. We calculated annual colectomy rates for nonmalignant colorectal polyps and stratified rates by age, sex, and race and ethnicity. Changes in rates over time were tested by the Cochran-Armitage test for a linear trend.

RESULTS:
Among 229,730 patients who were diagnosed with nonmalignant colorectal polyps between 2008 and 2018, 1,611 patients underwent a colectomy. Colectomy rates for nonmalignant colorectal polyps decreased significantly from 125 per 10,000 patients with nonmalignant polyps in 2008 to 12 per 10,000 patients with nonmalignant polyps in 2018 (P < 0.001 for trend). When stratified by age, sex, and race and ethnicity, colectomy rates for nonmalignant colorectal polyps also significantly declined from 2008 to 2018.

DISCUSSION:
In a large, ethnically diverse, community-based population in the United States, we found that colectomy rates for nonmalignant colorectal polyps declined significantly over the past decade likely because of the establishment of advanced endoscopy centers, improved care coordination, and an organized colorectal cancer screening program.
Differential Expression of Long Noncoding RNA HOTAIR in Intestinal Metaplasia and Gastric Cancer
Authors: Petkevicius Vytenis , Thon Cosima , Steponaitiene Ruta , Skieceviciene Jurgita , Janciauskas Dainius , Jechorek Doerthe , Malfertheiner Peter , Kupcinskas Juozas , Link Alexander 
Published: March 2022

INTRODUCTION:
High expression of HOTAIR promotes tumor growth and carries a dismal prognosis for the patient. We investigated the prognostic value of HOTAIR expression in gastric cancer (GC) and systematically delineate the expression in relation to Helicobacter pylori infection and preneoplastic changes.

METHODS:
HOTAIR expression was analyzed in surgical paired tissue samples of patients with GC and biopsy samples from patients with atrophic gastritis and/or intestinal metaplasia (AG ± -IM), chronic nonatrophic gastritis, and controls. The cancer genome atlas (TCGA) data were used for validation. HOTAIR expression was evaluated in sera and ascites of patients with GC. Quantitative HOTAIR expression analysis was performed using quantitative polymerase chain reaction, and LINE-1 methylation was assessed by bisulfite pyrosequencing.

RESULTS:
HOTAIR was more frequently detected in tumor tissues compared with adjacent gastric mucosa (65.4% vs 8.6%). HOTAIR expression was associated with depth of tumor invasion and tumor location and with shorter overall survival in patients with diffuse-type GC as confirmed in the TCGA cohort. HOTAIR was not detectable in controls but was found in 2.2% of patients with chronic nonatrophic gastritis and 18.3% of patients with AG ± IM, which was further associated with IM, grade of IM, and H. pylori positivity.

DISCUSSION:
HOTAIR expression was associated with GC and preneoplastic changes of stomach mucosa. Although HOTAIR expression was strongly linked to IM, HOTAIR expression was only associated with worse prognosis in Lauren diffuse and not intestinal type of GC. Further studies are needed to evaluate the value of HOTAIR as diagnostic and predictive biomarker in IM and translational therapeutic relevance of HOTAIR in diffuse-type GC.

JOURNAL/cltg/04.03/01720094-202205000-00011/inline-graphic1/v/2023-08-15T223532Z/r/image-tiff
Formación pedagógica y aprendizajes vitales de maestros becarios en la universidad industrial de Santander, Colombia
Authors: Rodríguez Denix Alberto , Bonilla Sánchez Gilberto , Cardona Ospina Roberto Alonso 
Published: March 2022

Introducción. La experiencia de formación docente en el contexto de la maestría en pedagogía en una universidad colombiana y con el auspicio del gobierno nacional es el eje central del presente ejercicio documental desde la experiencia docente orientada por maestros universitarios que lograron trascender el aprendizaje teórico para hacerlo vital. Método. La experiencia de los docentes participantes indica que hubo conexión directa con los grupos de maestros por ello puede indicarse que hubo Investigación-Acción de corte cualitativo, pero además se parte de un Estudio de Caso particular donde se hacen juiciosos análisis a partir de la observación participante de los investigadores desde experiencia pedagógica vivida. Resultados. Se halla que como escenario y punto común de la experiencia pedagógica con los becarios, pudieron afianzarse saberes pero a la vez tocar la sensibilidad y emocionalidad de aquellas personas que desde los diversos contextos de desempeño interpelaron sus prácticas pedagógicas y buscaron nuevos horizontes de sentido haciéndose sus propios investigadores. Discusión. La motivación y el deseo imperante de transformar la escuela desde la indagación de las propias prácticas pedagógicas teniendo como eje transversal el trabajo ingente por la educación emocional, las historia de vida y el pensamiento crítico constituyen los valores agregados que los maestrante cuidan y llevan ahora celosamente a las aulas, como depositarios de un renovado saber pedagógico que integra de manera particular el aprendizaje teórico con el mundo de vida de sus estudiantes.