bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental and psychosocial health among youth after their first psychiatric hospitalization: a feasibility study
Authors: Ferro Mark A. , Chan Christy K. Y. , Vanderkooy John D. , Horricks Laurie , Duncan Laura , Lipman Ellen L. 
Published: June 2022

Abstract
Objective
This pilot study investigated the feasibility of studying 12-month readmission of youth aged 10–16 years following their first psychiatric hospitalization and changes in youth mental and psychosocial health prospectively.

Results
Inpatient youth with a first psychiatric hospitalization and their parents were recruited from a regional hospital in Canada. Data were collected at recruitment, and at 3-, 6-, and 12-months post-discharge. Repeated measures ANOVA was performed to assess changes in health outcomes. Nineteen eligible youth were approached and 15 (78.9%) consented to participate (13.9 ± 2.0 years, 73.3% female). Eleven youth (73.3%) gave permission to contact their parents, all of whom participated (39.2 ± 7.6 years). Four youth dropped out of the study (26.7%) and six youth-parent dyads completed all four follow-ups. The readmission rate was 20.0% (n = 3) over 12 months. Significant changes in youth-reported symptoms of conduct disorder (F = 3.0, p = 0.06) and adverse childhood experiences (F = 3.4, p = 0.05) were found. Changes in parent-reported youth mental health symptoms (F = 3.1, p = 0.06), particularly among internalizing disorders, youth health-related quality of life (F = 11.3, p < 0.01), and youth disability (F = 2.7, p = 0.08) were significant. This preliminary work demonstrates the feasibility of, and need to, engage youth and their families to understand their mental and psychosocial health during this vulnerable period of time.
Narrative elaboration makes misinformation and corrective information regarding COVID-19 more believable
Authors: Greer Joanna , Fitzgerald Kaitlyn , Vijaykumar Santosh 
Published: June 2022

Abstract
Objective
People gather information about health topics from online channels oftentimes awash with misinformation. Investigating this problem during the COVID-19 pandemic is important, as the misinformation effect occurs when misleading details are embedded in narratives and questions. This pilot study investigated whether narrative elaboration increases believability in misinformation statements about COVID-19, and willingness to share these statements online.

Results
Results from our online survey (n = 80) demonstrated that narrative elaboration increased believability in both misinformation and accurate statements, with a more pronounced effect on younger adults. Future research may investigate cognitive vulnerabilities imposed by elaborate narratives embedded in online health misinformation with increased attention on developing misinformation resilience among younger adults.
Investigation of the location and secretion features of Candida albicans enolase with monoclonal antibodies
Authors: He Zhengxin , Piao Jingzi , Qiu Yanguang , Lei Daxin , Yang Yanhui , Shi Lanchun , Wang Fukun 
Published: June 2022

Abstract
Purpose
The glycolytic enzyme enolase plays important role in the pathogenesis of Candida albicans infection and has been also considered as a promising molecular marker for the diagnosis of invasive candidiasis. This study aimed to investigate the location and secretion features of Candida albicans enolase (CaEno) with a couple of specific monoclonal antibodies (mAbs).

Methods
Two mAbs named 9H8 and 10H8 against CaEno were generated by fusing SP2/0 myeloma cell with the spleen lymphocytes from CaEno immunized mice. The specificity of the mAbs was then validated by Western blot and liquid chromatography-mass spectrometry (LC–MS/MS). A diverse set of experiments were conducted based on the pair of mAbs which involved immunohistochemical staining analysis, whole cell enzyme-linked immunosorbent assay (ELISA), double antibody sandwich ELISA, and confocal microscopy to analyze the possible location and secretion features of CaEno.

Results
CaEno is abundantly expressed in the cytoplasm of C. albicans blastospores and is distributed in a ring-shaped pattern along the cell wall. CaEno appeared in the hyphal C. albicans as just a “mushroom” form. CaEno was found to be weakly expressed on the surface of blastospores but constantly expressed at various stages of growth. CaEno concentrations in C. albicans blastospores culture supernatant are considerably higher than in C. albicans hyphae culture supernatant. The dynamic changes of supernatant CaEno concentration in blastospores and hyphal C. albicans exhibit distinct features, although both appear to be associated with the C. albicans growth state. When cultivated under normal circumstances, however, no apparent CaEno degradation was seen in the cell-free supernatant.

Conclusion
Our results implied that CaEno was constantly expressed on the cell surface and its secretion features varied according to the growth stage of C. albicans. However, further experimental and theoretical studies are needed in future to identify the specific mechanisms by which this phenomenon can arise.
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling
Authors: Zhou Jie , Yang Junying , Dong Yuan , Shi Yaru , Zhu Endong , Yuan Hairui , Li Xiaoxia , Wang Baoli 
Published: June 2022

Abstract
Background
Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption. However, it remains to be clarified whether and how OSMR affects the differentiation of osteoblasts.

Methods
The expression level of OSMR during osteoblast and adipocyte differentiation was examined. The role of OSMR in the differentiation was investigated using in vitro gain-of-function and loss-of-function experiments. The mechanisms by which OSMR regulates bone cell differentiation were explored. Finally, in vivo function of OSMR in cell fate determination and bone homeostasis was studied after transplantation of OSMR-silenced bone marrow stromal cells (BMSCs) to the marrow of ovariectomized mice.

Results
OSMR was regulated during osteogenic and adipogenic differentiation of marrow stromal progenitor cells and increased in the metaphysis of ovariectomized mice. OSMR suppressed osteogenic differentiation and stimulated adipogenic differentiation of progenitor cells. Mechanistic investigations showed that OSMR inhibited extracellular signal-regulated kinase (ERK) and autophagy signaling. The downregulation of autophagy, which was mediated by ERK inhibition, suppressed osteogenic differentiation of progenitor cells. Additionally, inactivation of ERK/autophagy signaling attenuated the stimulation of osteogenic differentiation induced by Osmr siRNA. Furthermore, transplantation of BMSCs in which OSMR was silenced to the marrow of mice promoted osteoblast differentiation, attenuated fat accumulation and osteoclast differentiation, and thereby relieved the osteopenic phenotype in the ovariectomized mice.

Conclusions
Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice
Authors: Yang Zhiqi , Gong Mingyue , Jian Tingliang , Li Jin , Yang Chuanyan , Ma Qinlong , Deng Ping , Wang Yuxia , Huang Mingzhu , Wang Haoyu , Yang Shaofan , Chen Xiaowei , Yu Zhengping , Wang Manxia , Chen Chunhai , Zhang Kuan 
Published: June 2022

AbstractAging causes astrocyte morphological degeneration and functional deficiency, which impairs neuronal functions. Until now, whether age-induced neuronal deficiency could be alleviated by engraftment of glial progenitor cell (GPC) derived astrocytes remained unknown. In the current study, GPCs were generated from embryonic cortical neural stem cells in vitro and transplanted into the brains of aged mice. Their integration and intervention effects in the aged brain were examined 12 months after transplantation. Results indicated that these in-vitro-generated GPC-derived astrocytes possessed normal functional properties. After transplantation they could migrate, differentiate, achieve long-term integration, and maintain much younger morphology in the aged brain. Additionally, these GPC-derived astrocytes established endfeet expressing aquaporin-4 (AQP4) and ameliorate AQP4 polarization in the aged neocortex. More importantly, age-dependent sensory response degeneration was reversed by GPC transplantation. This work demonstrates that rejuvenation of the astrocyte niche is a promising treatment to prevent age-induced degradation of neuronal and behavioral functions.
DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis
Authors: Guan Haochen , Zhu Nan , Tang Gang , Du Yi , Wang Ling , Yuan Weijie 
Published: June 2022

Abstract
Background
Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DNMT1) in hepatitis B virus-associated glomerulonephritis (HBV-GN) remains unclear.

Methods
We explored the underlying mechanism by establishing HBV X protein (HBx) overexpressing renal tubular epithelial (HK-2) cells and human podocytes with DNMT1 knockdown. Using RNA-sequencing to determine the downstream targets of DNMT1 and evaluate its levels of promoter methylation. HBV transgenic mice were used to examine the effects of DNMT1 inhibitor on renal in vivo.

Results
DNMT1 was significantly upregulated in the renal tissue of HBV-GN patients, accompanied by injuries of HK-2 cells and podocytes. HBx markedly upregulated DNMT1 and induced epithelial-mesenchymal transition (EMT) and inflammation in HK-2 cells and human podocytes. This increased DNMT1 expression was attenuated after DNMT1 knockdown, accompanied by restored HK-2 cells and podocyte injuries resulting from the activation of PI3K/Akt/mTOR and nuclear factor-kappa B (NF-κB) pathways. Hypermethylation of the phosphatase and tensin homolog (PTEN) promoter and vitamin D receptor (VDR) was induced in HBx-overexpressing HK-2 cells and podocytes, respectively, whereas DNMT1 knockdown effectively corrected these alterations. Furthermore, PTEN and VDR ablation resulted in marked EMT and inflammation induction in HBx-overexpressing HK-2 cells and human podocytes even with DNMT1 knockdown. Downregulation of the PI3K/Akt/mTOR-related pathway attenuated HBx-induced EMT and inflammation in HK-2 cells. Luciferase reporter assay revealed VDR as a direct target of the Snail family transcriptional repressor 1 (SNAI1) in HBx-overexpressing podocytes. DNA methylation inhibitor 5-azacytidine alleviated urinary protein and renal inflammation in HBV transgenic mice via PTEN-PI3K/Akt signaling and VDR signaling axis.

Conclusions
Our study clarifies the potential epigenetic mechanisms underlying HBx-induced renal injuries in HBV-GN and the renoprotective effects of inhibiting DNMT1, which can provide important insights into the development of treatments for HBV-GN.
Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation
Authors: Cheon So Yeong , Song Juhyun 
Published: June 2022

AbstractNon-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin resistance, cerebrovascular dysfunction, gut dysbiosis, and neuroinflammation. Many recent studies have focused on the increasing prevalence of dementia in patients with NAFLD. Dementia is characterized by cognitive and memory deficits and has diverse subtypes, including vascular dementia, Alzheimer’s dementia, and diabetes mellitus-induced dementia. Considering the common pathological features of NAFLD and dementia, further studies on the association between them are needed to find appropriate therapeutic solutions for diseases. This review summarizes the common pathological characteristics and mechanisms of NAFLD and dementia. Additionally, it describes recent evidence on association between NAFLD and dementia progression and provides novel perspectives with regard to the treatment of patients with dementia secondary to NAFLD.
Exact recovery of sparse signals with side information
Authors: Luo Xiaohu , Feng Nianci , Guo Xuhui , Zhang Zili 
Published: June 2022

AbstractCompressed sensing has captured considerable attention of researchers in the past decades. In this paper, with the aid of the powerful null space property, some deterministic recovery conditions are established for the previous $$\ell _{1}$$

ℓ
1

–$$\ell _{1}$$

ℓ
1

method and the $$\ell _{1}$$

ℓ
1

–$$\ell _{2}$$

ℓ
2

method to guarantee the exact sparse recovery when the side information of the desired signal is available. These obtained results provide a useful and necessary complement to the previous investigation of the $$\ell _{1}$$

ℓ
1

–$$\ell _{1}$$

ℓ
1

and $$\ell _{1}$$

ℓ
1

–$$\ell _{2}$$

ℓ
2

methods that are based on the statistical analysis. Moreover, one of our theoretical findings also shows that the sharp conditions previously established for the classical $$\ell _{1}$$

ℓ
1

method remain suitable for the $$\ell _{1}$$

ℓ
1

–$$\ell _{1}$$

ℓ
1

method to guarantee the exact sparse recovery. Numerical experiments on both the synthetic signals and the real-world images are also carried out to further test the recovery performance of the above two methods.
The deception effect of FDA counteracting amplitude-comparison monopulse reconnaissance
Authors: Ge Jiaang , Xie Junwei 
Published: June 2022

AbstractConventional phased array radar can direct the high-gain beam, resulting in high visibility under the reconnaissance system and even direct exposure to the enemy. As an amplitude-based direction-finding system, the amplitude monopulse system can recognize the traditional radar signals. However, there are still some issues with the countermeasures of the monopulse system, so it is necessary to find better styles of jamming. Since the beam of the frequency diverse array (FDA) signal at a certain angle varies with the range, we studied the deception effect of the FDA against the amplitude-comparison monopulse direction-finding system. By analyzing the established FDA-based direction-of-arrival location deception model against the amplitude-comparison monopulse system, we found that the introduction of the frequency increment might cause the FDA signals to deceit the monopulse system in principle. Then, to indicate the superiority of our deception method, we obtain the instantaneous signal-to-noise ratio, Cramér–Rao lower bound, root-means-square error, and variation. Numerical simulation results demonstrate that the FDA can generate deceptive signals to counteract the amplitude-comparison monopulse direction-finding system.
Blowup for semilinear wave equation with space-dependent damping and combined nonlinearities
Authors: Yao Jiangyan , Ming Sen , Fan Xiongmei 
Published: June 2022

AbstractThis paper is concerned with the Cauchy problem for semilinear wave equation with space-dependent scattering damping and combined nonlinearities. The blowup results of solution are established by introducing proper test functions. Moreover, upper bound lifespan estimates of a solution to the Cauchy problem with small initial values are derived. To the best of our knowledge, the results in Theorems 1.1–1.2 are new.
Towards developing innovation management framework (IMF) for ICT organizations at Pakistan
Authors: Abbasi Eram , Amin Imran , Siddiqui Shama 
Published: June 2022

AbstractVarious aspects of innovation management have been discussed in literature over the past few decades. Most of the innovation management frameworks have been formulated by undertaking studies in the developed world and lack the industry/culture specific focus. In this paper, we revisit the generic innovation management studies to develop an innovation management framework for highlighting the factors affecting innovation specifically at the Information Communication Technology (ICT) sector of Pakistan. A detailed literature review has been conducted to identify the factors included in the past innovation management models. To identify the factors specific for Pakistan, senior-level professionals, working at the Pakistani ICT organizations were interviewed based on a survey. A comparative analysis of the innovation management frameworks for Pakistan against those previously found in literature revealed interesting similarities and differences. Based on the study findings, an innovation management framework is developed that highlights the present factors which are important for innovation in the ICT sector for Pakistan. This framework can be used by Pakistan and other underdeveloped countries for improving their innovation in ICT sectors in particular and other sectors in general.
How do aged-care staff feel about antimicrobial stewardship? A systematic review of staff attitudes in long-term residential aged-care
Authors: Singh Saniya , Degeling Chris , Fernandez Dominic , Montgomery Amy , Caputi Peter , Deane Frank P. 
Published: June 2022

Abstract
Background
Antimicrobial resistance (AMR) is a problem in residential aged care facilities (RACF). There is a gap in our understanding of how psychosocial barriers such as risk perceptions shape staff attitudes towards antimicrobial stewardship (AMS). We sought to ascertain the attitudinal domains that have been identified to be of importance to AMS in RACF and comment on how they have been measured empirically. Our aim was to consolidate what is known regarding staff attitudes and perceptions in order to inform future stewardship.

Method
We searched PsycINFO, PsycARTICLES, CINAHL Plus, MEDLINE, PubMed, Web of Science, Cochrane, and Scopus databases for primary studies of healthcare workers attitudes to AMS in RACF (1990-February 2021).

Results
14 Studies were included in the review, within which 10 domains were identified: attitudes towards antimicrobial prescribing; guidelines; educational interventions; self-confidence regarding clinical assessment and prescribing; awareness of AMR as a problem and stewardship as a priority; self-efficacy; perception of role; perception of risk; team culture and resident/family members expectations. 46 measures were developed across the 14 studies to measure the 10 domains. The variability in the attitudinal domains and how these domains were measured was large. Only 13% included psychometric data regarding reliability and/or internal consistency.

Conclusions
Attitudes are generally defined as having three evaluative bases: cognitive, behavioural, and affective. Findings from the current review suggest that the measures commonly used to capture healthcare staff attitudes to AMS do not sufficiently capture affect; particularly with respect to staff’s risk perceptions, perceptions of their role, and family members’ expectations. Given that affective processes have been postulated to influence medical decision making, these findings highlight the importance of understanding how staff, especially nurses feel about implementing AMS strategies and other peoples’ (e.g. residents and their families) perceptions of stewardship. It is expected that a more nuanced understanding of RACF nurses affective experiences when applying AMS, and their perceptions of the risks entailed, will help in reducing barriers to overprescribing antibiotics.
Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology
Authors: Paterno Giavanna , Bell Brach M. , Gorion Kimberly-Marie M. , Prokop Stefan , Giasson Benoit I. 
Published: June 2022

AbstractTau is a predominantly neuronal, soluble and natively unfolded protein that can bind and stabilize microtubules in the central nervous system. Tau has been extensively studied over several decades, especially in the context of neurodegenerative diseases where it can aberrantly aggregate to form a spectrum of pathological inclusions. The presence of tau inclusions in the form of neurofibrillary tangles, neuropil threads and dystrophic neurites within senile plaques are essential and defining features of Alzheimer’s disease. The current dogma favors the notion that tau is predominantly an axonal protein, and that in Alzheimer’s disease there is a redistribution of tau towards the neuronal soma that is associated with the formation of pathological inclusions such as neurofibrillary tangles and neuropil threads. Using novel as well as previously established highly specific tau antibodies, we demonstrate that contrary to this overwhelmingly accepted fact, as asserted in numerous articles and reviews, in adult human brain, tau is more abundant in cortical gray matter that is enriched in neuronal soma and dendrites compared to white matter that is predominantly rich in neuronal axons. Additionally, in Alzheimer’s disease tau pathology is significantly more abundant in the brain cortical gray matter of affected brain regions compared to the adjacent white matter regions. These findings have important implications for the biological function of tau as well as the mechanisms involved in the progressive spread of tau associated with the insidious nature of Alzheimer’s disease.
New insights into the deterioration of TiO2 based oil paints: the effects of illumination conditions and surface interactions
Authors: Schmitt Thomas , Rosi Francesca , Mosconi Edoardo , Shull Ken , Fantacci Simona , Miliani Costanza , Gray Kimberly 
Published: June 2022

Abstract
Titanium dioxide (TiO2) has been used in numerous paintings since its creation in the early 1920s. However, due to this relatively recent adoption by the art world, we have limited knowledge about the nature and risk of degradation in museum environments. This study expands on the existing understanding of TiO2 facilitated degradation of linseed oil, by examining the effect of visible light and crystallographic phase (either anatase or rutile) on the reactivity of TiO2. The present approach is based on a combination of experimental chemical characterization with computational calculation through Density Functional Theory (DFT) modeling of the TiO2-oil system. Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FT-IR) enabled the identification of characteristic degradation products during UV and visible light aging of both rutile and anatase based paints in comparison to BaSO4 and linseed oil controls. In addition, cratering and cracking of the paint surface in TiO2 based paints, aged under visible and UV–vis illumination, were observed through Scanning Electron Microscopy (SEM). Finally, Density Functional Theory (DFT) modeling of interactions between anatase TiO2 and oleic acid, a fatty acid component of linseed oil, to form a charge transfer complex explains one possible mechanism for the visible light activity observed in artificial aging. Visible light excitation of this complex sensitizes TiO2 by injecting an electron into the conduction band of TiO2 to generate reactive oxygen species and subsequent degradation of the oil binder by various mechanisms (e.g., formation of an oleic acid cation radical and other oxidation products).

Graphical Abstract