bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstructive sleep apnea in young Asian adults with sleep-related complaints
Authors: Chiu Hwa-Yen , Chou Kun-Ta , Su Kang-Cheng , Lin Fang-Chi , Liu Yung-Yang , Shiao Tsu-Hui , Chen Yuh-Min 
Published: November 2022

AbstractThis study aimed to investigate the proportion of young OSA adults with sleep-related complaints in a sleep center, affiliated with a tertiary medical center for over a decade. This study presents a chronicle change in the numbers of young adults receiving polysomnography (PSG) and young patients with OSA from 2000 to 2017. We further analyzed 371 young patients with OSA among 2378 patients receiving PSG in our sleep center from 2016 to 2017 to capture their characteristics. Young adults constituted a substantial and relatively steady portion of examinees of PSG (25.1% ± 2.8%) and confirmed OSA cases (19.8 ± 2.4%) even though the total numbers increased with the years. Young adults with OSA tend to be sleepier, have a greater body mass index, and have a higher percentage of cigarette smoking and alcohol consumption. They also complained more about snoring and daytime sleepiness. They had a higher apnea–hypopnea index on average and experienced more hypoxemia during their sleep, both in terms of duration and the extent of desaturation. Even though the prevalence of comorbidities increased with age, hypertension in young male adults carried higher risks for OSA. Young adults with OSA have constituted a relatively constant portion of all confirmed OSA cases across time. The young adults with OSA were heavier, more symptomatic, and with more severe severity.Clinical trial: The Institutional Review Board of Taipei Veterans General Hospital approved the study (VGHIRB No. 2018-10-002CC). The study is registered with ClinicalTrials.gov, number NCT03885440.
CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma
Authors: Kameda Takuro , Shide Kotaro , Kamiunten Ayako , Kogure Yasunori , Morishita Daisuke , Koya Junji , Tahira Yuki , Akizuki Keiichi , Yokomizo-Nakano Takako , Kubota Sho , Marutsuka Kosuke , Sekine Masaaki , Hidaka Tomonori , Kubuki Yoko , Kitai Yuichi , Matsuda Tadashi , Yoda Akinori , Ohshima Takayuki , Sugiyama Midori , Sashida Goro , Kataoka Keisuke , Ogawa Seishi , Shimoda Kazuya 
Published: November 2022

AbstractAdult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-κB signaling, such as CARD11, are detected in about 90% of patients. Utilizing mice expressing CD4+ T cell-specific CARD11(E626K) and/or CD4+ T cell-specific HBZ, namely CARD11(E626K)CD4-Cre mice, HBZ transgenic (Tg) mice, and CARD11(E626K)CD4-Cre;HBZ Tg double transgenic mice, we clarify these genes’ pathogenetic effects. CARD11(E626K)CD4-Cre and HBZ Tg mice exhibit lymphocytic invasion to many organs, including the lungs, and double transgenic mice develop lymphoproliferative disease and increase CD4+ T cells in vivo. CARD11(E626K) and HBZ cooperatively activate the non-canonical NF-κB pathway, IRF4 targets, BATF3/IRF4/HBZ transcriptional network, MYC targets, and E2F targets. Most KEGG and HALLMARK gene sets enriched in acute-type ATL are also enriched in double transgenic mice, indicating that these genes cooperatively contribute to ATL development.
Finding space for nature in cities: the considerable potential of redundant car parking
Authors: Croeser Thami , Garrard Georgia E. , Visintin Casey , Kirk Holly , Ossola Alessandro , Furlong Casey , Clements Rebecca , Butt Andrew , Taylor Elizabeth , Bekessy Sarah A. 
Published: November 2022

AbstractNature-based solutions (NBS) are recognised as a means to address challenges such as heatwaves, flooding and biodiversity loss. Delivering these benefits at scale will require large areas of scarce urban land to be converted into green space. Here we show an approach by which cities can make substantial progress towards their sustainability targets using NBS, by converting redundant street parking into biodiverse green space. We demonstrate that up to half of street parking in our case study municipality (The City of Melbourne) could be accommodated in garages within 200 m, freeing up large areas for greening. Our modelling projects significant benefits in terms of tree canopy over, stormwater and ecological connectivity. These would represent strong progress towards a number of the city’s ambitious NBS targets. As many cities allocate extensive areas to both street parking and off-street garages, this approach to freeing up space for nature in cities is widely applicable.
Dark spots on Mercury show no signs of weathering during 30 Earth months
Authors: Wang Yichen , Xiao Zhiyong , Xu Rui , Xiao Zhouxuan , Cui Jun 
Published: November 2022

AbstractDark spots on Mercury are recently-formed thin and low-reflectance materials that are related with volatile activity and supposed to be much shorter-lived than their central hollows. Containing unique information about the possible building blocks of Mercury, dark spots have unresolved darkening phases, formation mechanism, and lifetime. Here we investigated reflectance spectra, sub-resolution roughness, and temporal changes of dark spots using the full-mission dataset of MESSENGER. We find that dark spots have the highest concentration of graphite and an intense outgassing origin. Temporal imaging for dark spots reveals no detectable reflectance changes in 30 Earth months, and possibly over 40 Earth years. These observations demonstrate that thermally unstable sulfides such as MgS and CaS are not the major components in dark spots. Possible reflectance changes of dark spots may occur at much longer time scales, providing a reference for modeling the spectral behavior of graphite caused by space weathering on Mercury.
Der Mythos der 15°-Linksseitenlagerung zur Entlastung der Vena cava inferior
Authors: Massoth Christina , Kranke Peter , Wenk Manuel 
Published: November 2022

AbstractPositioning the pregnant patient in her third trimester in a 15° left lateral tilt position with the rationale to reduce inferior vena cava (IVC) compression is a longstanding practice of
both obstetric and anesthesia care. Recent data from MRI imaging studies have challenged this traditional dogma, since the IVC was found to remain compressed at a 15° angle, with a tilt of
at least 30° necessary to provide a certain relief of the vessel. However, even the 15° tilt is regularly underestimated by visual judgement and improperly executed, but comes with several
disadvantages without adding any benefit on fetal outcome. Current evidence supports all efforts to cease the dogma of a 15° left lateral position for its lack of effectiveness and instead
put emphasis on proven measures, such as volume coloading and the timely administration of vasopressors.
Homeopathy as an Adjuvant to Standard Care in Moderate and Severe Cases of COVID-19: A Single-Blind, Randomized, Placebo-Controlled Study
Authors: Kaur Harleen , Kaushik Subhash , Singh Gurpreet , Kumar Arvind , Singh Shweta , Chatterjee Tania , Ali Syed , Gautam Khushbu , Parewa Maneet , Verma Naval Kumar , Bhatnagar Sushma , Singh Suraj Pal , Shekhar Varun , Khurana Anil 
Published: November 2022

Abstract
Objectives This study aimed to evaluate whether individualized homeopathic medicines have a greater adjunctive effect than adjunctive placebos in the treatment of moderate and severe cases of coronavirus disease 2019 (COVID-19).
Methods The study was a randomized, single-blind, prospective, placebo-controlled clinical trial set in the clinical context of standard care.
Intervention Patients of either sex, admitted in a tertiary care hospital, suffering from moderate or severe COVID-19 and above 18 years of age were included. In total, 150 patients were recruited and then randomly divided into two groups to receive either individualized homeopathic medicines or placebos, in addition to the standard treatment of COVID-19.
Outcome Measures The primary outcome was time taken to achieve RT-PCR-confirmed virus clearance for COVID-19. Secondary outcomes were changes in the Clinical Ordinal Outcomes Scale (COOS) of the World Health Organization, the patient-reported MYMOP2 scale, and several biochemical parameters. Parametric data were analyzed using unpaired t-test. Non-parametric data were analyzed using the Wilcoxon signed rank test. Categorical data were analyzed using Chi-square test.
Results In total, 72 participants of the add-on homeopathy (AoH) group showed conversion of RT-PCR status to negative, in an average time of 7.53 ± 4.76 days (mean ± SD), as compared with 11.65 ± 9.54 days in the add-on placebo (AoP) group (p = 0.001). The mean COOS score decreased from 4.26 ± 0.44 to 3.64 ± 1.50 and from 4.3 ± 0.46 to 4.07 ± 1.8 in the AoH and AoP groups respectively (p = 0.130). The mortality rate for the AoH group was 9.7% compared with 17.3% in the AoP group. The MYMOP2 scores between the two groups differed significantly (p = 0.001), in favor of AoH. Inter-group differences in the pre- and post- mean values of C-reactive protein, fibrinogen, total leukocyte count, platelet count and alkaline phosphatase were each found to be statistically significant (p <0.05), favoring AoH; six other biochemical parameters showed no statistically significant differences.
Conclusion The study suggests homeopathy may be an effective adjunct to standard care for treating moderate and severe COVID-19 patients. More rigorous, including double-blinded, studies should be performed to confirm or refute these initial findings.
Effect of Distraction Interventions on Anxiety in Children Undergoing Surgery: A Meta-Analysis
Authors: Mathias Edlin Glane , Pai Mamatha Shivananda , Bramhagen Ann-Cathrine 
Published: November 2022

AbstractDue to the unfamiliarity of the surroundings, children having surgery endure worry and tension. Untreated anxiety in children impairs postoperative healing and causes changes in postoperative behavior. The purpose of this review was to determine the efficacy of distraction therapies on anxiety in children undergoing surgery. The systematic review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards. PubMed via MEDLINE, CINAHL, ProQuest, Web of Science, and the Cochrane Central Register of Controlled Trials were used to find relevant trials. Full-text papers published in English from January 1, 2000 to December 31, 2021 were included. Children undergoing surgery aged 1 to 18 years were included. A data extraction form was created to extract data from the selected studies. According to the Cochrane risk of bias assessment tool, studies were classified as “low risk,” “high risk,” or “unclear risk.” Review Manager software was used to do a quantitative meta-analysis. Thirteen studies looked at the effect of distraction intervention on children. Nine of them were selected for meta-analysis. The distraction interventions included in this review were: handheld video game, play dough and play with blocks and puzzles, tablet-based interactive distraction, animated video, painting and storytelling, age-appropriate video, distraction with video glasses, watching a movie, and bringing favorite toy during hospital stay. Meta-analysis showed that distraction interventions are effective on preoperative anxiety in children (standardized mean difference = –17.07, 95% confidence interval: 27.11–7.02, p = 0.0009).
Bilosomes as a Potential Carrier to Enhance Cognitive Effects of Bacopa monnieri Extract on Oral Administration
Authors: Narayanan V. Anoop , Sharma Ankitha , S. Rajesh K. , R. Arunraj T. , P. Gururaj M. , S. Parasuraman , John Anish 
Published: November 2022

AbstractThe Indian system of medicine, Ayurveda employs Bacopa monnieri extract (BME) for memory enhancement. This study attempts to prepare and test a more potent formulation by incorporating BME in nanovesicles. BME-loaded liposomes and bilosomes (bile salt-stabilized liposomes) were formulated using soy phosphatidylcholine. Liposomes and bilosomes had homogeneous size distribution and an average size of 285.7 nm and 84 nm, respectively, with satisfactory zeta potential. Spherical multilamellar bilosomes and unilamellar liposomes were observed under transmission electron microscope (TEM), with BME entrapment efficiency of 85% and 45%, respectively. During a 72 h interval, bilosomes and liposomes released 78% and 65% of the loaded BME, exhibiting a biphasic release, following the Higuchi model diffusion. Both liposomes and bilosomes were stable in simulated gastric and intestinal fluids. When tested on dementia-induced Swiss albino mouse models using the Y-maze apparatus, the bilosome-treated group showed significant cognition enhancement activity than those treated with liposomal vesicles. The better pharmacological effect shown by bilosomes may be attributed to better bioavailability, possibly augmented by higher entrapment efficiency, and improved vesicle integrity afforded by bile salts. Likewise, bilosomes were more stable than liposomes in simulated gastric and intestinal fluids. Taken together, innovative formulation techniques hold substantial promise for enhancing the ethnopharmacological claims of BME.
Dementia Prevention in Clinical Practice
Authors: Niotis Kellyann , Akiyoshi Kiarra , Carlton Caroline , Isaacson Richard 
Published: November 2022

AbstractOver 55 million people globally are living with dementia and, by 2050, this number is projected to increase to 131 million. This poses immeasurable challenges for patients and their families and a significant threat to domestic and global economies. Given this public health crisis and disappointing results from disease-modifying trials, there has been a recent shift in focus toward primary and secondary prevention strategies. Approximately 40% of Alzheimer's disease (AD) cases, which is the most common form of dementia, may be prevented or at least delayed. Success of risk reduction studies through addressing modifiable risk factors, in addition to the failure of most drug trials, lends support for personalized multidomain interventions rather than a “one-size-fits-all” approach. Evolving evidence supports early intervention in at-risk patients using individualized interventions directed at modifiable risk factors. Comprehensive risk stratification can be informed by emerging principals of precision medicine, and include expanded clinical and family history, anthropometric measurements, blood biomarkers, neurocognitive evaluation, and genetic information. Risk stratification is key in differentiating subtypes of dementia and identifies targetable areas for intervention. This article reviews a clinical approach toward dementia risk stratification and evidence-based prevention strategies, with a primary focus on AD.
Molecular dynamics simulation of cancer cell membrane perforated by shockwave induced bubble collapse
Authors: Linh Nguyen Hoang , Man Viet Hoang , Li Mai Suan , Wang Junmei , Derreumaux Philippe , Mai Thi Ly , Nguyen Phuong H. 
Published: November 2022

It has been widely accepted that cancer cells are softer than their normal counterparts. This motivates us to propose, as a proof-of-concept, a method for the efficient delivery of therapeutic agents into cancer cells, while normal cells are less affected. The basic idea of this method is to use a water jet generated by the collapse of the bubble under shockwaves to perforate pores in the cell membrane. Given a combination of shockwave and bubble parameters, the cancer membrane is more susceptible to bending, stretching, and perforating than the normal membrane because the bending modulus of the cancer cell membrane is smaller than that of the normal cell membrane. Therefore, the therapeutic agent delivery into cancer cells is easier than in normal cells. Adopting two well-studied models of the normal and cancer membranes, we perform shockwave induced bubble collapse molecular dynamics simulations to investigate the difference in the response of two membranes over a range of shockwave impulse 15–30 mPa s and bubble diameter 4–10 nm. The simulation shows that the presence of bubbles is essential for generating a water jet, which is required for perforation; otherwise, pores are not formed. Given a set of shockwave impulse and bubble parameters, the pore area in the cancer membrane is always larger than that in the normal membrane. However, a too strong shockwave and/or too large bubble results in too fast disruption of membranes, and pore areas are similar between two membrane types. The pore closure time in the cancer membrane is slower than that in the normal membrane. The implications of our results for applications in real cells are discussed in some details. Our simulation may be useful for encouraging future experimental work on novel approaches for cancer treatment.
Axion-Photon Conversion of LHAASO Multi-TeV and PeV Photons
Authors: Zhang Guangshuai , Ma Bo-Qiang 
Published: November 2022

Abstract
The Large High Altitude Air Shower Observatory (LHAASO) has reported the detection of a large number of multi-TeV-scale photon events including also several PeV-scale gamma-ray-photon events with energy as high as 1.4 PeV. The possibility that some of these events may have extragalactic origins is not yet excluded. Here we propose a mechanism for the traveling of very-high-energy (VHE) and ultra-high-energy (UHE) photons based upon the axion-photon conversion scenario, which allows extragalactic above-threshold photons to be detected by observers on the Earth. We show that the axion-photon conversation can serve as an alternative mechanism, besides the threshold anomaly due to Lorentz invariance violation, for the very-high-energy features of the newly observed gamma ray burst GRB 221009A.
Topological effects produced by point-like global monopole with Hulthen plus screened Kratzer potential on Eigenvalue solutions and NU-method
Authors: Ahmed Faizuddin 
Published: November 2022

Abstract
In this article, the approximate eigenvalue solution of the Schrödinger non-relativistic equation in 3D with a non-central potential of superposition of Hulthen potential and screened Kratzer potential in a point-like global monopole space-time is obtained. We employ a suitable approximation scheme like the Greene-Aldrich approximation in the centrifugal and reciprocal terms that appear in the radial equation and solve it using the parametric Nikiforov-Uvarov method. The results are analyzed for the topological defects and the magnetic flux and show that the eigenvalue solution gets modified in comparison to the flat space result with this superposed potential. Finally, we utilize the eigenvalue solution to some diatomic molecular potential models, such as screened Kratzer and Varshni potential and discuss the effects on the eigenvalue solutions.
Development of LGAD sensors with a thin entrance window for soft X-ray detection
Authors: Zhang J. , Barten R. , Baruffaldi F. , Bergamaschi A. , Borghi G. , Boscardin M. , Brückner M. , Carulla M. , Centis Vignali M. , Dinapoli R. , Ebner S. , Ficorella F. , Fröjj¨dh E. , Greiffenberg D. , Hammad Ali O. , Heymes J. , Hasanaj S. , Hinger V. , King T. , Kozlowski P. , Lopez-Cuenca C. , Mezza D. , Moustakas K. , Mozzanica A. , Paternoster G. , Ronchin S. , Ruder C. , Schmitt B. , Thattil D. 
Published: November 2022

Abstract
We show the developments carried out to improve the silicon sensor technology for the detection of soft X-rays with hybrid X-ray detectors. An optimization of the entrance window technology is required to improve the quantum efficiency. The LGAD technology can be used to amplify the signal generated by the X-rays and to increase the signal-to-noise ratio, making single photon resolution in the soft X-ray energy range possible. In this paper, we report first results obtained from an LGAD sensor production with an optimized thin entrance window. Single photon detection of soft X-rays down to 452 eV has been demonstrated from measurements, with a signal-to-noise ratio better than 20.
Geodetic deformation measurement and analysis of the ATLAS experimental cavern at CERN
Authors: Niewiem W. , Mergelkuhl D. , Gayde J.-C. 
Published: November 2022

Abstract
Caverns for large physics detectors, such as the one for the Large Hadron Collider experiments, sit nearly 100 m underground and measure several tens of meters in length, width and height. The deformation of the cavern base slab over decades has a direct influence on the relative alignment of detectors with respect to the accelerator. The expected long-term movements are larger than the fine adjustment of detectors and accelerators. In this paper, the measured deformations of the ATLAS experiment's main cavern floor and lateral walls over nearly 20 years have been analysed. The measurement series have been performed in various time intervals getting down to half a year. The used measurement techniques, such as the polar method (total station and laser tracker) and precise levelling, allow to obtain sub-millimetre precision. Even if the deformations are significantly (four times) lower compared to the predictions of the civil engineering consultants at the moment of the cavern construction, the measured ones reach values up to 5.0 mm for the base slab and up to 14.7 mm for the lateral walls.
Validation of transcriptome signature reversion for drug repurposing in oncology
Authors: Koudijs Karel K M , Böhringer Stefan , Guchelaar Henk-Jan 
Published: November 2022

Abstract
Transcriptome signature reversion (TSR) has been extensively proposed and used to discover new indications for existing drugs (i.e. drug repositioning, drug repurposing) for various cancer types. TSR relies on the assumption that a drug that can revert gene expression changes induced by a disease back to original, i.e. healthy, levels is likely to be therapeutically active in treating the disease. Here, we aimed to validate the concept of TSR using the PRISM repurposing data set, which is—as of writing—the largest pharmacogenomic data set. The predictive utility of the TSR approach as it has currently been used appears to be much lower than previously reported and is completely nullified after the drug gene expression signatures are adjusted for the general anti-proliferative downstream effects of drug-induced decreased cell viability. Therefore, TSR mainly relies on generic anti-proliferative drug effects rather than on targeting cancer pathways specifically upregulated in tumor types.
FUSTA: leveraging FUSE for manipulation of multiFASTA files at scale
Authors: Delehelle Franklin , Roest Crollius Hugues 
Published: November 2022

Abstract

Motivation
FASTA files are the de facto standard for sharing, manipulating and storing biological sequences, while concatenated in multiFASTA they tend to be unwieldy for two main reasons: (i) they can become big enough that their manipulation with standard text-editing tools is unpractical, either due to slowness or memory consumption; (ii) by mixing metadata (headers) and data (sequences), bulk operations using standard text streaming tools (such as sed or awk) are impossible without including a parsing step, which may be error-prone and introduce friction in the development process.

Results
Here, we present FUSTA (FUse for faSTA), a software utility which makes use of the FUSE technology to expose a multiFASTA file as a hierarchy of virtual files, letting users operate directly on the sequences as independent virtual files through classical file manipulation methods.

Availability and implementation
FUSTA is freely available under the CeCILL-C (LGPLv3-compatible) license at https://github.com/delehef/fusta.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.