bluuebunny/crossref_metadata_2025_split huggingface dataset:
What are we allocating and who decides? Democratising understanding of groundwater and decisions for judicious allocations in India
Authors: Aslekar Uma , Joshi Dhaval , Kulkarni Himanshu 
Published: August 2022

Abstract
India is the largest user of groundwater in the world. With current dependency on the resource, challenges pertaining to management and governance of groundwater in the country have increased tremendously. To address these challenges, various policy and programmatic interventions have been devised and implemented by state and non-state actors. In this chapter, we question the techno-managerial nature of these solutions and propose a socio-hydrogeological approach that integrates the multidisciplinary and decentralised nature of groundwater problems. To illustrate this, we draw on case studies that have emerged as part of our work on strengthening participatory processes of aquifer monitoring and mapping, decentralised groundwater allocation for agricultural decisions and management strategies that evolve through local institutions. Various programmes are underway in the country aimed at improving participation in governance of groundwater resources. If we are to achieve our goals of collectively and sustainably managing this invisible resource, there is a need to adopt approaches that move beyond the techno-managerial paradigm and embody local ways of knowing, using, and managing groundwater.
Characteristics and mechanism of persulfate activated by natural siderite for water disinfection
Authors: Li Guo-Qiang , Wang Chaoyi , Zhang Yingying , Wan Hongyou , Dou Ming , Xu Hongbin 
Published: August 2022

Abstract
In this study, low-cost siderite was used to activate peroxydisulfate (PDS, S2O82-)-inactivated Enterococcus faecalis to study the inactivation characteristics and mechanism of siderite/PDS. The results showed that the siderite/PDS had a better inactivation effect on Enterococcus faecalis at pH 3. The sterilization effect increases with the increase of siderite dosage, PDS concentration and temperature. The inactivation rate is decreased with the increase of initial bacterial concentration. Inorganic ions and natural organic matter (NOM) can inhibit the inactivation effect of this technology, and the inhibition intensity is NOM &gt; HCO3− &gt; NO3−. The free radical quenching test shows that HO• is the main oxidizing substance in the sterilization process of siderite/PDS technology. In addition, the main disinfection mechanism is highly reactive oxygen species destroying the cell wall of bacteria and releasing organic compounds in cells. After siderite was reused for four times, simply washing siderite would recover almost 80% of the removal of Enterococcus faecalis in siderite/PDS, indicating that siderite has the potential of recycling.
Prebiotics and Probiotics: Effects on Dyslipidemia and NAFLD/NASH and the Associated Mechanisms of Action
Authors: Fernández-Martínez Eduardo , Rodríguez-Pastén Alicia , Pérez-Hernández Nury , Soria-Jasso Luis E. , Cariño-Cortés Raquel 
Published: August 2022

Background:Non-alcoholic fatty liver disease (NAFLD) is now considered the most common chronic liver disease worldwide. NAFLD is related to changes in lipid metabolism and is characterized by the increase or accumulation of fat in hepatocytes that may progress to non-alcoholic steatohepatitis (NASH), which leads to the appearance of inflammatory processes. Treatment consists of changes in diet, physical activity, and weight control; however, these disorders represent a health problem and require the development of novel alternatives to treatment and prevention.Review and Conclusion:NAFLD/NASH are strongly associated with other disorders, such as metabolic syndrome (MetS); in fact, NAFLD is considered the hepatic manifestation of MetS. These disorders are related to other components of MetS, including dyslipidemia, which is characterized by an imbalance in blood cholesterol and triglyceride levels. Prebiotics and probiotics have beneficial effects on treating and preventing several ailments, including liver diseases. Specifically, in dyslipidemia, NAFLD, and NASH, probiotics play a fundamental role in conducting the biotransformation of primary bile acids into secondary bile acids, which generally have important activity as immunomodulators and metabolism regulators. The mechanisms of action of pre and probiotics involve the activity of bile acid receptors, such as FXR and TGR-5, and the events resulting from their activation. Therefore, prebiotics and probiotics may be reasonable options to prevent and treat metabolic-related liver diseases
Topical Mosquito Repellent Formulations for Enhanced Repellency Time
and Reduced Toxicity
Authors: Higuchi Celio Takashi , Filho Newton Andreo , Lopes Patricia Santos , Grice Jeffrey Ernest , Leite-Silva Vânia Rodrigues 
Published: August 2022

Abstract:
Mosquito-borne diseases such as dengue, malaria, yellow fever, chikungunya and Zika virus affect millions of people worldwide each year. Vector control and personal protection are very important to minimize the spread of diseases, and the use of repellent is an economical practice to prevent them. The application of repellent, which acts on the skin to form a vapor layer with a repellent odor to mosquitos, is recommended as an economical prevention and practice. The natural botanical product Citronella is an effective mosquito repellent due to the high concentrations of active chemical constituents present, notably terpenic alcohols. However, citronella tends to evaporate quickly from the skin surface, resulting in a rapid loss of activity. Strategies to increase repellency time, while at the same time minimizing toxicity, are major focuses of research and development in natural repellent products. Here we highlight the role of extended-release systems (ERS) of citronella oil in this approach.
Pharmaceutical Potential of Constituents from Azadirachta indica and
their Specific Role as Anti-cancer Agents
Authors: Jeelani Ishtiaq , Bhosale Mrinalini , Qadir Tanzeela , Sharma Praveen Kumar , Nawaz Allah , Sharif Aamir , Amin Andleeb , Sheikh Alisha , Ahmad Saeed , Kukreja Vinita , Kulkarni Snehal , Padhye Subhash 
Published: August 2022

:
Neem (Azadirachta indica), a Meliaceae family member, is a rapidly growing tropical
evergreen tree with a thick, branching trunk. It has been used for hundreds of years in traditional
Indian medicine as a home cure against numerous human illnesses in the Indian and African
continents. Different components of the plant, including the flowers, leaves, seeds, and bark, have
been used to treat both acute and chronic human illnesses, as well as an insecticide, antibiotic,
larvicidal, antimalarial, antibacterial, antiviral, and spermicidal. The plant's anticancer qualities
have been extensively researched in terms of its preventative, protective, tumor-suppressive,
immunomodulatory, and apoptotic actions against different cancers and their molecular processes.
Triple-negative breast cancer (TNBC), which lacks the expression of progesterone and estrogen
receptors, has a dismal prognosis and no viable therapeutic options. Gedunin compound isolated
from Azadirachta indica's seed oil shows potential anticancer effect against triple-negative breast
cancer (TNBC) cancer cells, which acts as heat shock protein 90 (Hsp90) inhibitor.
In vitro Inhibition Profiles and Molecular Docking Analysis of Benzohydrazide
Derivatives on Red Blood Cell Carbonic Anhydrases Isozymes
Authors: Güller Pınar , Korkmaz Işıl Nihan , Kalın Ramazan , Öztekin Aykut , Özdemir Hasan 
Published: August 2022

Background:
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes that contain
zinc ions on the active side and convert carbon dioxide to bicarbonate in metabolism. Human CA-I
and CA-II, which are the most abundant CA isozymes in erythrocytes, have been therapeutic targets
in the treatment of glaucoma, hypertension, ulcer, osteoporosis, and, neurological disorders. Benzohydrazides
are biologically active compounds, and their various pharmacological effects have
been reported.

Aim:
In light of this, the objective of this study was to investigate the in vitro effects of benzohydrazide
derivatives on the activities of hCA-I and hCA-II, determine the compounds as selective inhibitors
for these isoenzymes, and estimate the inhibition mechanism through molecular docking
studies.

Method:
In this work, we synthesized the 10 different derivatives of benzohydrazide containing
various functional group of different positions.

Results:
As a result, all benzohydrazide derivatives inhibited both isozymes in vitro and 2-amino 3-
nitro benzohydrazide (10) was found to be the most efficient inhibitor of both hCA isozymes with
the IC50 values of 0.030 and 0.047 μM, respectively. In the molecular docking studies, 3-amino 2-
methyl benzohydrazide (3) had the lowest estimated free binding energies against hCA isozymes as
-6.43 and -6.13 kcal/mol.

Conclusion:
In this study, hCA-I & II isozymes were isolate from human erythrocytes. CA isozymes
are one of these target enzymes. WBC hope that the benzohydrazide derivatives, can guide
remedies targeting carbonic anhydrase.
A Review on Hyphenated Techniques in Analytical Chemistry
Authors: Baviskar Kajal Pratik , Jain Dipali Vivek , Pingale Sushal Dilip , Wagh Shekhar Sudam , Gangurde Swapnil Parashram , Shardul Siddharth Ashok , Dahale Aditya Ravindra , Jain Kishor Sanchalal 
Published: August 2022

Background:
In chemical and pharmaceutical analysis, hyphenated techniques range from the
combinations involving separation-separation, separation-identification and identification-identification
techniques and are widely used nowadays, as they hold many advantages like fast accurate analysis, a
higher degree of automation, higher sample throughput, better reproducibility, specificity and sensitivity.
They also reduce contamination due to closed systems and offer simultaneous separation and quantification,
leading to better analysis.

Objective:
Though many reviews have appeared on hyphenated analytical techniques till date, in the past
decade, their use has increased manifold and therefore, we thought it imperative to review the latest progress
in this field. In the present article, an attempt has been made to cover the latest information on various
hyphenated techniques like LC-MS (Liquid Chromatography-Mass Spectroscopy), GC-MS (Gas
Chromatography-Mass Spectroscopy), LC-IR (Liquid Chromatography-Infra-Red Spectroscopy), as well
as, LC-MS-MS (Liquid Chromatography-Mass Spectroscopy-Mass Spectroscopy), LC-NMR-MS (Liquid
Chromatography-Nuclear Magnetic Resonance-Mass Spectroscopy), etc.

Conclusion:
This review describes a total of seventeen different hyphenated techniques, comprising
mainly of the combinations of chromatographic techniques with spectroscopic techniques. We have tried
to cover the latest information on various double hyphenated techniques like LC-MS , LC-NMR, LC-IR,
HPTLC-MS, HPTLC-IR, GC-MS, GC-IR, GC-TLC, GC-AES, MS-MS, CE-MS, GC-NMR, as well as,
triple hyphenated techniques like LC-MS-MS, LC-NMR-MS, LC-UV-MS, GC-MS-MS, GC-IR-MS.
Mainly the principle, instrumentation, applications, and advantages of each of the techniques are discussed
in this review. Also, disadvantages of a few techniques have been mentioned.
Inter-rater and Intra-Rater Reliability Test with Goodenough-Harris Drawing Test
Authors: Tarigan Medianta , Fadillah Fadillah 
Published: August 2022

Introduction:There are various methods to measure intelligence in children, one of them is by drawing method. Goodenough-Harris Drawing Test (GHDT) is the first cognitive measurement tool developed based on drawing. Giving quantitative scores in drawing methods has been a challenging task, especially in controlling the level of subjectivity. It requires psychometric reliability evidence to make sure the result is free from bias.Methods:Drawings of 799 children (kindegarten/4 to 6 y.o= 412, primary school/7 to 9 y.o= 387 ; boys= 388, girls= 411) were examined to investigate inter-rater and intra-rater reliability in GHDT scoring. Data are scored by two raters who have been given special training on the scoring system based on the manual book. Pearson correlation is used to analyzed drawing reliability.Results:Significant correlation between the scores of two rates were 0.840 (p<.001) for the man drawing, and 0.844 (p<.001) for the woman drawing. In addition, intra-rater reliability ranged from 0.880 to 0.963.Conclusion:The study showed that GHDT has a high-reliability score by raters who trained based on a manual book GHDT scoring system. In addition, these results also showed scoring criteria were applied consistently.
Evaluation of Nurses’ Knowledge and Attitudes towards Older Adults and Associated Factors
Authors: Sedri Nadia , Zakeri Mohammad Ali , Zare Zardiny Mohammadreza , Tavan Asghar 
Published: August 2022

Background:
Due to the increased risk of developing chronic diseases among older adults, their demand for health care has increased. Preparing nurses to care for the older adults is one of the most difficult challenges in nursing education.

Objective:
This study investigated nurses’ knowledge and attitudes towards older adults and demographic and occupational features that affect them.

Methods:
This cross-sectional study was conducted on 412 participants from July to October 2020. Patients were selected using a random sampling method. Three questionnaires were used: a socio-demographic form, an Older Patient in Acute Care Survey, and a Knowledge about Older Patients-Quiz.

Results:
According to the Pearson correlation test, there is a statistically significant and positive correlation between knowledge and general opinion (P = 0.000), (r = 0.271) as well as between practice experiences and general opinion (P = 0.000), (r = 0.205) of nurses about older adult’s care. There was no statistically significant relationship between knowledge and practice experiences (P = 0.857), (r = -. 009).

Conclusion:
Having a better understanding of the needs of the older adults would improve the quality of care that nurses provide to them.
Physicochemical and Therapeutic Properties of Malaysian Stingless Bee
Kelulut Honey in Comparison with Yemeni Sidr Honey
Authors: Al-Kafaween Mohammad A. , Hilmi Abu Bakar Mohd , Al-Jamal Hamid Ali Nagi 
Published: August 2022

:
Kelulut and Yemeni Sidr honey has been documented to have various therapeutic
properties. Investigations associated with the medicinal properties and physicochemical
characteristics of Kelulut and Yemeni Sidr honey are growing broadly and receiving raised
awareness. This study incorporated and analysed the findings on the biological and physicochemical
properties of Kelulut and Yemeni Sidr honey. Kelulut and Yemeni Sidr honey was
found to have a wide variety of biological effects attributed to their physicochemical characteristics.
Findings showed that Kelulut and Yemeni Sidr honey have anti-bacterial, antibiofilm,
anti-virulence, anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, antiobesity
and wound-healing properties. The physicochemical properties of Kelulut and Yemeni
Sidr honey were compared and discussed and results revealed that they have high-quality
contents and excellent antioxidant sources.
Prebiotics as Adjunctive Therapy in Diabetes: A Review of Prebiotics in Diabetes
Authors: Prajapati Bhupendra , Kumar Akash , Pramanik Jhilam 
Published: August 2022

Abstract:
Prebiotic compounds are used by the host microbiome and confer health benefits to the host. Food intake affects the composition of the gut microbiome. The number and composition of gut flora have been linked to metabolic diseases. Diabetes is a chronic condition that alters blood sugar levels. The main form of energy for the body is blood glucose, which is produced from the food. Nutritional interventions can be used to manage blood sugar levels. There are different types of compounds that can be used as prebiotics such as; Inulin-type fructans, Trans-galactooligosaccharides, Lactulose, Isomaltooligosaccharide, Lactosucrose, Xylooligosaccharides, Soybean oligosaccharide, and Glucooligosaccharides. Research evidence suggests that prebiotic consumption supports or improves the gut microbiome, inhibits reactive oxygen species production (ROS), reduces serum glutamic pyruvic transaminase (SGPT) levels, reduces oxidative stress, inhibits NF-κB activation process, reduces inflammation, improves dysfunction, improves insulin resistance, decreases malondialdehyde levels in serum, improves glucose tolerance, decreases intestinal permeability, inhibits α-glucosidase and improves glycemic control. This review focuses on the potential of prebiotic use as adjuvant therapy in diabetes.
An Overview of Face Image Forgery Detection
Authors: He Defen , Liu Shuai , Jin Xin , Huang Shanshan , Jiang Qian 
Published: August 2022

:
With the development of face forgery techniques, the spread and malicious abuse of
forged images have become a thought-provoking problem, and the face forgery detection technique
has also attracted people's attention. Academia has carried out in-depth research and discussion on
detection techniques. This review discussed different face forgery methods and detection techniques.
Four categories of detection methods are introduced: 1) detection method based on spatial
domain, 2) detection method based on the frequency domain, 3) detection method based on biological
information, and 4) detection method of multiple feature domains. This paper discussed each
detection method's evolution and development in recent years. We paid special attention to the detection
method of multiple feature domains and focused on the progress that has been made and the
challenges it faced. In addition, this paper discussed open issues and future development trends that
should be paid attention to in this field.
PENDIDIKAN ANAK DALAM ISLAM
Authors: Syafrida Siregar Lis Yulianti 
Published: August 2022

Pendidikan Islam untuk anak-anak adalah kegiatan penting yang dilakukan oleh
setiap orang tua Muslim, jika mereka ingin anak-anak mereka menjadi anak-anak
shaleh dalam keluarga mereka. Hal ini juga menjadi tujuan penelitian oleh para
ahli pendidikan Islam. Pendidikan anak harus mendasar pada Islam yang
bersumber dari Al-Qur'an dan hadits terutama tentang keberadaan kewajiban
untuk belajar bagi setiap muslim, laki-laki atau perempuan, anak-anak dan orang
dewasa. Sementara tujuan pendidikan islam pada anak adalah: merawat jiwa
anak-anak untuk menjadi jiwa yang lebih baik (fitrah) dalam Islam dan membawa
anak-anak ke kehidupan yang penuh belas kasih sayang, bahagia di dunia dan
akhirat.
MODEL PEMBELAJARAN QUANTUM DALAM MENGEMBANGKAN POTENSI OTAK ANAK USIA DINI DI LEMBAGA PAUD
Authors: Azhari Supian 
Published: August 2022

Pembelajaran Quantum merupakan model pembelajaran berbasis mencakup seluruh aspek perkembangan stimulus otak anak usia dini. Hal ini, penting untuk dilakukan agar diaktualisasikan dalam proses pembelajaran, lebih khususnya pada pembelajaran anak usia dini (PAUD). Fokus penelitian ini, akan mengkaji beberapa aspek yang urgen untuk menjawab penelitian ini, Pertama, memahami prinsip-prinsip model pembelajaran Quantum. Kedua, langkah-langkah aplikasin model pembelajaran Quantum anak usia dini (PAUD). Ketiga, menganalisis implikasi Quantum sebagai basis mengembangkan potensi anak usia dini dalam proses pembelajaran. Adapun penelitian ini yaitu penelitian kualitatif deskriptif dimana salah satu penelitian yang menggambarkan sesuatu yang ada dilapangan, mengamati dan menganalisa apa saja yang ditemukan dalam penelitian tersebut: planning, organizing, acuatatingdan controlling, dari berbagai penyebab dalam memiliki konstribusi dengan penerapan model pembelajaran paud. Hasil penelitian ini menunjukkan bahwa, pembelajaran model Quantum dapat mengembangkan potensi otak khusunya pendidikan anak usia dini (PAUD). Secara realitas, pengaruh pembelajaran Quantum dapat menumbuhkan daya ingat dalam pembelajaran, menguatkan daya ingatan, dan menumbuhkan pembelajaran yang efektif sesuai dengan aplikasi pembelajaran tersebut.
MODEL PENDIDIKAN BAGI ANAK ABK: HOME SCHOOLING
Authors: Dara Gebrina Rezieka Fidya Ismiulya, Khamim Zarkasih Putroe, 
Published: August 2022

Setiap anak memiliki hak mendapatkan pendidikan dan berhak memilih model pendidikan yang diinginkannya yang sesuai dengan minat, bakat, kemampuan, dan gaya belajarnya tidak terkecuali bagi Anak Berkebutuhan Khusus. Secara umum terdapat tiga jenis pilihan pendidikan untuk anak ABK yaitu Sekolah Luar Biasa (SLB), Sekolah Inklusi dan Home schooling. Terjadinya hambatan dalam sekolah SLB dan Inklusi pada anak ABK mengakibatkan orang tua memilih jenis layanan lainnya yaitu Home schooling. Tujuan penelitian ini adalah untuk melihat bagaimana model pendidikan ABK dengan layanan Homeschooling. Metode penelitian yang digunakan pada artikel ini ialah metode pemdekatan kepustakaan. Teknik analisis data yang digunakan dalam penelitian ini adalah metode analisis (content analysis). Hasil penelitian ini menunjukkan bahwa Home schooling merupakan pendidikan alternatif yang dapat dipilih dan dilaksanakan oleh masyarakat. Pelaksanaan pendidikan berbasis rumah dan lebih fleksibel dibandingkan sekolah formal. Home schooling menjadi salah suatu usaha dan alternatif yang dilakukan untuk mencapai tujuan dan fungsi pendidikan nasional dalam mengembangkan potensi peserta didik dan untuk mencerdaskan kehidupan bangsa.
UPAYA PENINGKATAN MUTU SEKOLAH DENGAN OPTIMALISASI MANAJEMEN SUMBER DAYA MANUSIA
Authors: Mifta Hurrahma & Faruq Avero Dimas Aryadi, Syarani Margarita, Rohimah, 
Published: August 2022

Sekolah merupakan bangunan atau lembaga untuk belajar dan mengajar serta tempat menerima dan memberi pelajaran. Sekolah dipimpin oleh seorang kepala sekolah. Kepala sekolah dibantu oleh wakil kepala sekolah. Untuk meningkatkan mutu sekolah kepala sekolah harus mengoptimalkan manajemen sumber daya manusia. Kepala sekolah adalah bagian penting dalam struktur komite sekolah didalam suatu sekolah, baik dari tingkat pendidikan dasar sampai tingkat pendidikan atas. Dalam pelaksanaannya, kepala sekolah mempunyai banyak sekali tugas, wewenang, dan juga fungsi, diantaranya sebagai perencanaan program, pelaksanaan rencana kerja dan sebagai supervisor serta evaluator. Faktor pendukung dan juga penghambat bagi terlaksananya manajemen sumber daya manusia harus diperhatikan agar terciptanya kinerja yang baik dan tujuan sekolah akan tercapai
MENINGKATKAN PROFESIONALITAS LULUSAN PROGRAM STUDI BIMBINGAN DAN KONSELING ISLAM
Authors: Jamil Yusuf M. 
Published: August 2022

Profesionalitas sebagai suatu keterampilan untuk mampu bertindak secara professional adalah sebuah tuntutan yang wajib dikuasai oleh seseorang lulusan S-1 sesuai dengan bidang kesarjanaannya. Program Studi Bimbingan dan Konseling Islam (BKI) mempunyai tugas dan fungsi menyelenggarakan pendidikan akademik (Sarjana Konseling Islam) dan sedang berjuang untuk dapat menyelenggarakan pendidikan profesi (Konselor Islam) secara otomatis memiliki kewajiban untuk meningkatkan kualitas lulusannya mencakup kompetensi akademik dan kompetensi profesional sebagai satu keutuhan. Prodi BKI dalam mengemban tugas ini juga menghadapi tantangan yang bersifat internal mengenai terbatasnya sumber daya tenaga pendidik berkualitas dan linier dengan bidang ilmu yang dikembangkannya. Di samping itu, Prodi BKI juga menghadapi tantangan eksternal di era disrupsi yang amat sukar diprediksi arah perkembangannya. Solusi yang ditawarkan di sini adalah uji kompetensi terhadap para lulusan dengan pendekatan analisis SWOT dan difokuskan ketika mereka hendak memasuki dunia kerja. Kepada para lulusan diajukan sejumlah pertanyaan yang berkaitan dengan factor kekuatan (S) dan kelemahan (W) yang ada pada dirinya, serta factor peluang (O) dan factor ancaman (T) yang terbentang di hadapan diri mereka. Dengan hasil ujia kompetensi ini diharapkan Pengelola Prodi BKI dapat menyusun strategi pemantapan kekuatan (S) dan memperbesar peluang (O), serta membenahi factor-faktor kelemahan (W) dan mengurangi factor-faktor ancaran/hambatan (T) untuk diterapkan dalam pengelolaan program studi, sekaligus diharapkan para lulusan dapat memasuki dunia kerja sesuai kompetensi akademik dan kompetensi profesionalnya.