bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the quality of a network of vector-field sensors
Authors: Smiga Joseph A. 
Published: January 2022

AbstractAn experiment consisting of a network of sensors can endow several advantages over an experiment with a single sensor: improved sensitivity, error corrections, spatial resolution, etc. However, there is often a question of how to optimally set up the network to yield the best results. Here, we consider a network of devices that measure a vector field along a given axis; namely for magnetometers in the Global Network of Optical Magnetometers for Exotic physics searches (GNOME). We quantify how well the network is arranged, explore characteristics and examples of ideal networks, and characterize the optimal configuration for GNOME. We find that by re-orienting the sensitive axes of existing magnetometers, the sensitivity of the network can be improved relative to the past science runs.
Nossos corpos por nós mesmas: o processo de tradução e adaptação cultural em palimpsesto
Authors: Lima Érica 
Published: January 2022

O objetivo deste trabalho é discutir alguns aspectos da tradução do livro Our Bodies, Ourselves, cujo primeiro volume, Nossos corpos por nós mesmas, acaba de ser publicado no Brasil. Para tanto, serão apresentadas as três etapas principais do processo, divididas em camadas. Na primeira, temos a preparação, com reflexão teórica que fundamenta o trabalho de tradução colaborativa e ativista e definição da metodologia adotada. Em seguida, trazemos algumas considerações sobre a tradução propriamente dita e, por fim, apresentamos cinco depoimentos sobre os diferentes impactos que o projeto tem trazido para as alunas e dos alunos que participaram da tradução. O texto apresenta, ainda, exemplos de adaptação cultural para diferentes países, em especial para realidade brasileira, e algumas conclusões.
Tobacco Consumption and High‐Sensitivity Cardiac Troponin I in the General Population: The HUNT Study
Authors: Skranes Julia Brox , Lyngbakken Magnus Nakrem , Hveem Kristian , Røsjø Helge , Omland Torbjørn 
Published: January 2022

Background
Cardiac troponins represent a sensitive index of subclinical myocardial injury and are associated with increased risk of cardiovascular events in the general population. Despite positive associations with cardiovascular risk of both cardiac troponins and cigarette smoking, concentrations of cardiac troponin I measured by high‐sensitivity assays (hs‐cTnI) are paradoxically lower in current smokers than in never‐smokers. The impact of smoking intensity and time from smoking cessation on hs‐cTnI remains unknown.

Methods and Results

hs‐cTnI concentrations were measured in 32028 subjects free from cardiovascular disease enrolled in the prospective, population‐based HUNT (Trøndelag Health Study). Tobacco habits were self‐reported and classified as never (n=14 559), former (n=14 248), and current (n=3221) smokers. Current smokers exhibited significantly lower concentrations of hs‐cTnI than never‐smokers (
P
<0.001). In adjusted models, both current smoking (−17.3%; 95% CI, −20.6 to −13.9%) and former smoking (−6.6%; 95% CI, −8.7 to −4.5%) were associated with significantly lower hs‐cTnI concentrations. Among former smokers, higher smoking burden (>10 pack‐years) were associated with lower concentrations of hs‐cTnI. Time since smoking cessation was associated with increasing concentrations of hs‐cTnI in a dose‐dependent manner (
P
for trend<0.001), and subjects who quit smoking >30 years ago had concentrations of hs‐cTnI comparable with those of never‐smokers.

Conclusions
In the general population, both current and former cigarette smoking is associated with lower concentrations of hs‐cTnI. In former smokers, there was a dose‐response relationship between pack‐years of smoking, and hs‐cTnI. Time since smoking cessation was associated with increasing concentrations of hs‐cTnI, indicating a continuum of hs‐cTnI from current smoker to never‐smokers.
Thinking across Frames – Temporally Extended Consciousness and the Animation Timeline
Authors: Buchanan Andrew 
Published: January 2022

Abstract
This article explores ways in which animation production technologies (including pre-cinema, film, and digital tools) have evolved as a system that abstracts time, primarily through its spatialization. This abstraction necessitates certain assumptions about the nature of time, including its linearity and directionality. Animation technologies have evolved so as to support various modes of temporally extended consciousness; an animator’s craft thinks and works through time. Embedded within digital production technologies, the animator is faced with a new philosophical instrument: the animation timeline. The main timeline utility in most animation software adopts a linear, mechanical model of time with the individual frame as the base unit. However, digital animation timeline can also complicate the spatialized temporal dimension, as the timeline is also embedded within animated objects in motion paths and other interface elements . As animated objects always exist through time, not merely within individual frames, the animation software tools for working with time both confine and unlock opportunities for working with time.
Prior’s Turn to Medieval Logic
Authors: Jakobsen David 
Published: January 2022

Abstract
The peculiar aspect of medieval logic, that the truth-value of propositions changes with time, gradually disappeared as Europe exited the Renaissance. In modern logic, it was assumed by W.V.O. Quine that one cannot appreciate modern symbolic logic if one does not take it to be tenseless. A.N. Prior’s invention of tense-logic challenged Quine’s view and can be seen as a turn to medieval logic. However, Prior’s discussion of the philosophical problems related to quantified tense-logic led him to reject essential aspects of medieval logic. This invites an evaluation of Prior’s formalisation of tense-logic as, in part, an argument in favour of the medieval view of propositions. This article argues that Prior’s turn to medieval logic is hampered by his unwillingness to accept essential medieval assumptions regarding facts about objects that do not exist. Furthermore, it is argued that presentists should learn an important lesson from Prior’s struggle with accepting the implications of quantified tense-logic and reject theories that purport to be presentism as unorthodox if they also affirm Quine’s view on ontic commitment. In the widest sense: philosophers who, like Prior, turn to the medieval view of propositions must accept a worldview with facts about individuals that, in principle, do not supervene (present tense) on being, for they do not yet exist.
The Response of Creative Class Members to Regions Vying to Attract Them With Subsidies
Authors: Batabyal Amitrajeet A. , Beladi Hamid 
Published: January 2022

There are no theoretical studies in regional science that examine which region to locate in from the standpoint of a creative class member, given that the pertinent regional authorities (RAs) are competing among themselves to attract the creative class using subsidies. This gap provides the motivation for our paper. This paper’s contribution is that it is the first to theoretically study the regional location choice of creative class members when the RAs of the locations in which they might locate are using subsidies to attract them. Specifically, a knowledge good producing creative class member must decide which of two regions ( A or B) to locate his plant in. This good is produced using a Cobb–Douglas function with creative and physical capital. We analyze plant location in four cases. In the benchmark case, we show that the representative creative class member ought to locate his plant in the less expensive region B. Next, we show that a small subsidy to creative capital by region A switches the plant location decision from region B to A. Finally, when both regions grant identical subsidies to creative capital, the representative creative class member is indifferent between locating in regions A and B. So, for identical subsidies to affect the plant location decision, they are better targeted to physical and not to creative capital. JEL Codes: R11, R58
An Email Coaching Option Increases Participant Program Utilization and Coach Productivity
Authors: Garrels Samantha , Macias Elizabeth , Bender Eric , Spoonheim Joel , Kottke Thomas E. 
Published: January 2022

Purpose To assess impact of adding an email option to phone-based coaching on the number of coaching sessions completed. Design Retrospective analysis of a change in program design. Setting A health plan health and wellness coaching service. Subjects Six thousand six hundred twenty four individuals who scheduled at least one coaching session. Intervention Adding an email option to phone coaching May 1 to August 31, 2020. Measures Association of a participant using an email coaching option with completing 3 coaching sessions; overall number of participants completing 3 coaching sessions when email is offered; participant satisfaction rates; and, average number of participants coached per coach by month. Analysis χ2; linear and logistic regression with gender, age, and education as covariates. Results When we offered email coaching, 29.6% of eligible participants used the option, and compared with the same months the prior year, the proportion of participants completing 3 sessions during those months was higher (73% vs 67%). ( P < .0001) 96.5% of participants who used email, vs 92.0% who did not, completed 3 sessions before their employer’s benefit qualifying deadline. ( P < .0001) More than 85% who responded to the email coaching survey expressed satisfaction. On average, each coach served 43% (486 vs 340) more participants per month when we offered email coaching. ( P < .0001). Conclusion Adding email coaching to phone coaching can increase program utilization by individuals who use email, increase overall program utilization, generate high levels of participant satisfaction, and increase the number of participants served per coach.
Lifetime and Aging Degradation Prognostics for Lithium-ion Battery Packs Based on a Cell to Pack Method
Authors: Che Yunhong , Deng Zhongwei , Tang Xiaolin , Lin Xianke , Nie Xianghong , Hu Xiaosong 
Published: January 2022

AbstractAging diagnosis of batteries is essential to ensure that the energy storage systems operate within a safe region. This paper proposes a novel cell to pack health and lifetime prognostics method based on the combination of transferred deep learning and Gaussian process regression. General health indicators are extracted from the partial discharge process. The sequential degradation model of the health indicator is developed based on a deep learning framework and is migrated for the battery pack degradation prediction. The future degraded capacities of both battery pack and each battery cell are probabilistically predicted to provide a comprehensive lifetime prognostic. Besides, only a few separate battery cells in the source domain and early data of battery packs in the target domain are needed for model construction. Experimental results show that the lifetime prediction errors are less than 25 cycles for the battery pack, even with only 50 cycles for model fine-tuning, which can save about 90% time for the aging experiment. Thus, it largely reduces the time and labor for battery pack investigation. The predicted capacity trends of the battery cells connected in the battery pack accurately reflect the actual degradation of each battery cell, which can reveal the weakest cell for maintenance in advance.
Exploring the transportome of the biosurfactant producing yeast Starmerella bombicola
Authors: Claus Silke , Jezierska Sylwia , Elbourne Liam D. H. , Van Bogaert Inge 
Published: January 2022

AbstractStarmerella bombicola is a non-conventional yeast mainly known for its capacity to produce high amounts of the glycolipids ‘sophorolipids’. Although its product has been used as biological detergent for a couple of decades, the genetics of S. bombicola are still largely unknown. Computational analysis of the yeast’s genome enabled us to identify 254 putative transporter genes that make up the entire transportome. For each of them, a potential substrate was predicted using homology analysis, subcellular localization prediction and RNA sequencing in different stages of growth. One transporter family is of exceptional importance to this yeast: the ATP Binding Cassette (ABC) transporter Superfamily, because it harbors the main driver behind the highly efficient sophorolipid export. Furthermore, members of this superfamily translocate a variety of compounds ranging from antibiotics to hydrophobic molecules. We conducted an analysis of this family by creating deletion mutants to understand their role in the export of hydrophobic compounds, antibiotics and sophorolipids. Doing this, we could experimentally confirm the transporters participating in the efflux of medium chain fatty alcohols, particularly decanol and undecanol, and identify a second sophorolipid transporter that is located outside the sophorolipid biosynthetic gene cluster.
Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January–August 2020
Authors: Ugarte Maider Pagola , Achilleos Souzana , Quattrocchi Annalisa , Gabel John , Kolokotroni Ourania , Constantinou Constantina , Nicolaou Nicoletta , Rodriguez-Llanes Jose Manuel , Huang Qian , Verstiuk Olesia , Pidmurniak Nataliia , Tao Jennifer Wenjing , Burström Bo , Klepac Petra , Erzen Ivan , Chong Mario , Barron Manuel , Hagen Terje P. , Kalmatayeva Zhanna , Davletov Kairat , Zucker Inbar , Kaufman Zalman , Kereselidze Maia , Kandelaki Levan , Le Meur Nolwenn , Goldsmith Lucy , Critchley Julia A. , Pinilla Maria Angelica , Jaramillo Gloria Isabel , Teixeira Domingos , Goméz Lara Ferrero , Lobato Jackeline , Araújo Carolina , Cuthbertson Joseph , Bennett Catherine M. , Polemitis Antonis , Charalambous Andreas , Demetriou Christiana A. ,   On behalf of the C-MOR consortium
Published: January 2022

Abstract
Background
Understanding the impact of the burden of COVID-19 is key to successfully navigating the COVID-19 pandemic. As part of a larger investigation on COVID-19 mortality impact, this study aims to estimate the Potential Years of Life Lost (PYLL) in 17 countries and territories across the world (Australia, Brazil, Cape Verde, Colombia, Cyprus, France, Georgia, Israel, Kazakhstan, Peru, Norway, England & Wales, Scotland, Slovenia, Sweden, Ukraine, and the United States [USA]).

Methods
Age- and sex-specific COVID-19 death numbers from primary national sources were collected by an international research consortium. The study period was established based on the availability of data from the inception of the pandemic to the end of August 2020. The PYLL for each country were computed using 80 years as the maximum life expectancy.

Results
As of August 2020, 442,677 (range: 18–185,083) deaths attributed to COVID-19 were recorded in 17 countries which translated to 4,210,654 (range: 112–1,554,225) PYLL. The average PYLL per death was 8.7 years, with substantial variation ranging from 2.7 years in Australia to 19.3 PYLL in Ukraine. North and South American countries as well as England & Wales, Scotland and Sweden experienced the highest PYLL per 100,000 population; whereas Australia, Slovenia and Georgia experienced the lowest. Overall, males experienced higher PYLL rate and higher PYLL per death than females. In most countries, most of the PYLL were observed for people aged over 60 or 65 years, irrespective of sex. Yet, Brazil, Cape Verde, Colombia, Israel, Peru, Scotland, Ukraine, and the USA concentrated most PYLL in younger age groups.

Conclusions
Our results highlight the role of PYLL as a tool to understand the impact of COVID-19 on demographic groups within and across countries, guiding preventive measures to protect these groups under the ongoing pandemic. Continuous monitoring of PYLL is therefore needed to better understand the burden of COVID-19 in terms of premature mortality.
RETRACTED ARTICLE: The LMCD1-AS1/miR-526b-3p/OSBPL5 axis promotes cell proliferation, migration and invasion in non-small cell lung cancer
Authors: Hu Rui , Yu Yankai , Wang Haining 
Published: January 2022

Abstract
Purpose
To explore the specific role and regulatory mechanism of oxysterol binding protein like 5 (OSBPL5) in non-small cell lung cancer (NSCLC).

Methods and results

Quantitative real-time polymerase chain reaction (qRT-PCR) analysis demonstrated that OSBPL5 expression was notably elevated in NSCLC tissues and cell lines, and Kaplan–Meier analysis manifested that high OSBPL5 expression was closely related to the poor prognosis of NSCLC patients. Besides, according to the results from western blot analysis, cell counting kit-8, EdU and Transwell assays, knockdown of OSBPL5 suppressed NSCLC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process. Additionally, by performing qRT-PCR analysis, luciferase reporter and RNA pull-down assays, we verified that OSBPL5 was a downstream target of miR-526b-3p and long noncoding RNA (lncRNA) LMCD1-AS1 served as a sponge for miR-526b-3p. Moreover, from rescue assays, we observed that OSBPL5 overexpression offset LMCD1-AS1 knockdown-mediated inhibition in cell proliferation, migration, invasion and EMT in NSCLC.

Conclusions
This paper was the first to probe the molecular regulatory mechanism of OSBPL5 involving the LMCD1-AS1/miR-526b-3p axis in NSCLC and our results revealed that the LMCD1-AS1/miR-526b-3p/OSBPL5 axis facilitates NSCLC cell proliferation, migration, invasion and EMT, which may offer a novel therapeutic direction for NSCLC.
Acacetin inhibits invasion, migration and TGF-β1-induced EMT of gastric cancer cells through the PI3K/Akt/Snail pathway
Authors: Zhang Guangtao , Li Zhaoyan , Dong Jiahuan , Zhou Weili , Zhang Zhanxia , Que Zujun , Zhu Xiaohong , Xu Yan , Cao Nida , Zhao Aiguang 
Published: January 2022

Abstract
Background
Epithelial-to-mesenchymal transition (EMT) is a pivotal cellular phenomenon involved in tumour metastasis and progression. In gastric cancer (GC), EMT is the main reason for recurrence and metastasis in postoperative patients. Acacetin exhibits various biological activities. However, the inhibitory effect of acacetin on EMT in GC is still unknown. Herein, we explored the possible mechanism of acacetin on EMT in GC in vitro and in vivo.

Methods
In vitro, MKN45 and MGC803 cells were treated with acacetin, after which cell viability was detected by CCK-8 assays, cell migration and invasion were detected by using Transwell and wound healing assays, and protein expression was analysed by western blots and immunofluorescence staining. In vivo, a peritoneal metastasis model of MKN45 GC cells was used to investigate the effects of acacetin.

Results
Acacetin inhibited the proliferation, invasion and migration of MKN45 and MGC803 human GC cells by regulating the expression of EMT-related proteins. In TGF-β1-induced EMT models, acacetin reversed the morphological changes from epithelial to mesenchymal cells, and invasion and migration were limited by regulating EMT. In addition, acacetin suppressed the activation of PI3K/Akt signalling and decreased the phosphorylation levels of TGF-β1-treated GC cells. The in vivo experiments demonstrated that acacetin delayed the development of peritoneal metastasis of GC in nude mice. Liver metastasis was restricted by altering the expression of EMT-related proteins.

Conclusion
Our study showed that the invasion, metastasis and TGF-β1-induced EMT of GC are inhibited by acacetin, and the mechanism may involve the suppression of the PI3K/Akt/Snail signalling pathway. Therefore, acacetin is a potential therapeutic reagent for the treatment of GC patients with recurrence and metastasis.
Stakeholder views of the development of a clinical quality registry for interventional radiology: a qualitative study
Authors: Haig Ylva , Feiring Eli 
Published: January 2022

Abstract
Background
Clinical quality registries (CQRs) can likely improve quality in healthcare and research. However, studies indicate that effective use of CQRs is hindered by lack of engagement and interest among stakeholders, as well as factors related to organisational context, registry design and data quality. To fulfil the potential of CQRs, more knowledge on stakeholders’ perceptions of the factors that will facilitate or hamper the development of CQRs is essential to the more appropriate targeting of registry implementation and the subsequent use of the data. The primary aim of this study was to examine factors that can potentially affect the development of a national CQR for interventional radiology in Norway from the perspective of stakeholders. Furthermore, we wanted to identify the intervention functions likely to enable CQR development. Only one such registry, located in Sweden, has been established. To provide a broader context for the Norwegian study, we also sought to investigate experiences with the development of this registry.

Methods
A qualitative study of ten Norwegian radiologists and radiographers using focus groups was conducted, and an in-depth interview with the initiator of the Swedish registry was carried out. Questions were based on the Capability, Opportunity and Motivation for Behaviour Model and the Theoretical Domains Framework. The participants’ responses were categorised into predefined themes using a deductive process of thematic analysis.

Results
Knowledge of the rationale used in establishing a CQR, beliefs about the beneficial consequences of a registry for quality improvement and research and an opportunity to learn from a well-developed registry were perceived by the participants as factors facilitating CQR development. The study further identified a range of development barriers related to environmental and resource factors (e.g., a lack of organisational support, time) and individuallevel factors (e.g., role boundaries, resistance to change), as well as several intervention functions likely to be appropriate in targeting these barriers.

Conclusion
This study provides a deeper understanding of factors that may be involved in the behaviour of stakeholders regarding the development of a CQR. The findings may assist in designing, implementing and evaluating a methodologically rigorous CQR intervention.