bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha-mangostin counteracts hyperuricemia and renal dysfunction by inhibiting URAT1 renal transporter in insulin resistance rat model
Authors: Soetikno Vivian , Murwantara Andriyani , Jusuf Ahmad Aulia , Louisa Melva 
Published: July 2022

Abstract
Background
Alpha-mangostin (AM) has been shown to have hypoglycemic activity. This study aimed to analyze the effects of AM at a dose of 100 mg/kg and 200 mg/kg to alleviate hyperuricemia and renal dysfunction on high-fat/high-glucose diet and low dose streptozotocin (HF/HG/STZ) injection-induced IR rat model. IR was induced in male Wistar rats by giving a HF/HG diet for 11 weeks and single injection of STZ (35 mg/kg, i.p.), then divided randomly into IR rats, IR rats treated with AM 100 and 200 mg/kgBW given by gavage for 8 weeks. At the end of the 11th week, all rats were killed, and the kidneys were taken to be analyzed for urate transporters 1 (URAT1) and glucose transporters 9 (GLUT9). We also assessed serum uric acid, proteinuria, BUN, creatinine clearance, HOMA-IR, and fasting blood glucose (FBG).

Results
We have found the significant increase in HOMA-IR and FBG levels of the IR rats, in comparison with its control groups, which were decreased significantly after AM administration at both doses. URAT1 and GLUT9 mRNA and protein expressions in kidney in the IR + AM at both doses groups also decreased compared those in the IR without treatment group, though the decrease in GLUT9 did not appear to be statistically significant. Consequently, hyperuricemia and renal dysfunction were attenuated by AM treatment at both doses.

Conclusion
After considering all findings, AM might be a potential candidate to ameliorate IR-induced hyperuricemia and renal dysfunction at least in part by modulating the renal URAT1.
46 XY, Female. Complete androgen insensitivity syndrome: a case report
Authors: Grądzik Anna , Gorajek Anna , Kudan Małgorzata , Osiejewska Aleksandra , Mikut Karolina 
Published: July 2022

Introduction: Androgen insensitivity syndrome (AIS) is an inherited disorder of sexual development caused by mutations in the androgen receptor encoding gene.
Case report: A female patient born in 1984, at the age of 17, was diagnosed with complete androgen insensitivity syndrome, during the diagnosis of primary amenorrhea. She was assigned grade 7 in the Quigley scale. Cytogenetic analysis showed a 46 XY karyotype. Gynecological examination revealed a blind ending vagina and a lack of uterus. Physical examination revealed normal breast development and scanty pubic and axillary hair. The patient kept seeing herself as a woman. At the age of 18, the patient underwent laparoscopic gonadectomy. After the procedure, the patient was under medical supervision and was taking orally 1 mg of estradiol daily. At the age of 24 patient was diagnosed with. The patient received sodium alendronate and ibandronic acid. The level of FSH was 35.50 mlU / ml and LH was 13.05 mlU/ml.
Discussion: Quigley grades 6 and 7 correspond to complete androgen insensitivity. The genitals are completely feminized and newborns at birth are assigned as females. The diagnosis is usually established during the diagnostics of primary amenorrhea. CAIS is associated with high risks of gonad carcinogenesis and therefore a gonadectomy must be performed. Hormone replacement therapy (HRT) is required after gonadectomy in order to maintain secondary sexual characteristics. Due to the high risk of osteoporosis patient requires calcium and vitamin D supplementation and bone density control. The prognosis is good, and gonadectomy and HRT usually give satisfactory long-term results.
Eating disorders in children and adolescents - the current state of knowledge
Authors: Mandera-Grygierzec Amanda , Kostrzewska Paulina , Szuster Ewa , Pawlikowska-Gorzelańczyk Anna , Lebioda Aneta 
Published: July 2022

Introduction. Eating disorders (ED) are a group of severe mental health disorders with high prevalence, mortality and associated morbidity. The most common eating disorders are anorexia nervosa, bulimia nervosa and binge-eating disorder.
Objective. The aim of the study was to evaluate prevalence, risk factors, clinical manifestation as well as complications for proper diagnostic and treatment of eating disorders.
Materials and method. The literature review included articles from Google Scholar databases and PubMed. Articles published in 2013 or later were mainly considered.
Brief description of the state of knowledge. The prevalence of eating disorders vary according to gender. There are a variety of risk factors that can be divided into family history, individual and possible triggers. The most common risk factors include family history of mental disorders. Studies have shown that premorbid overweight is more frequent in male. In the diagnosis of eating disorders, the ICD-10 and DSM-5 classification is used. Complications of this disease can manifest itself from various systems of the body. Proper cooperation between the pediatrician and the patient is very important. Treatment of eating disorders focuses on psychotherapy, especially family-based treatment. Worse results are obtained due to underdiagnosis and late initiation of treatment.
Summary. Pediatricians are the first healthcare professionals which have contact with young patients, so education about the first symptoms and consequences of not receiving appropriate treatment is essential.
Study Comparing Effect of Single Dose Antibiotic Prophylaxis versus Conventional Antibiotic Coverage in Clean, Elective Surgeries – A Randomized Controlled Clinical Trial
Authors: Maramreddy Lokesh Reddy  , Tharun Ganapathy Chitrambalam  , Sundeep Selvamuthukumaran  , Parivallal Damodaran  , Abhinav Bharadwaj Rajkumar  
Published: July 2022

BACKGROUND
Postoperative wound infection remains the most common complication of surgery. With the fear of developing wound infection after surgery, many surgeons administer antibiotics for 7 -10 days even in clean uncontaminated cases. This practice is not only expensive to the patients but also can lead to hospital-acquired infections. We wanted to assess the effectiveness and efficacy of single-dose antibiotics in clean elective surgical cases in this study.
METHODS
A prospective interventional study was conducted in the General Surgery department, SRM Medical College Research Centre, Kattankulathur for a period of 18 months between May 2018 and October 2019. In this study, 143 patients were selected according to the inclusion criteria. All the data findings were recorded and analysed.
RESULTS
Out of 143 patients presented with clean cases, 72 cases were included in the study group and 71 cases in the control group as per the inclusion criteria. In the present study, the incidence of postoperative infection was equal i.e., 6 % in both groups. However, the grade of infection varied. The difference was not statistically significant.
CONCLUSIONS
Based on my study I would like to conclude that it is recommendable to use single-dose antibiotic prophylaxis for clean surgical cases, as per the study results there is not much difference in the occurrence of SSI when compared to multiple doses.
Estudo preliminar da composição, riqueza e similaridade de comunidades de macrófitas aquáticas (Tonantins, Amazonas)
Authors: Coelho Neto Miguel Gomes , Souza Luciane Lopes de 
Published: July 2022

Estudos da composição, riqueza e similaridade de macrófitas aquáticas em diferentes lagos amazônicos são ferramentas importantes para conservar a diversidade de espécies presentes nessa região. O objetivo deste trabalho foi investigar as espécies que compõe as comunidades de macrófitas aquáticas e analisar comparativamente estas comunidades dos lagos (Tinequara e Eumaca Comprido) localizados no município de Tonantins, Estado do Amazonas. O método aplicado para identificação dos espécimes foi a análise morfológica, através de fotografias e baseada em cartilhas e chaves. Para avaliar o grau de similaridade entre as comunidades foi utilizado o índice de Jaccard. Os resultados obtidos revelaram 11 famílias de macrófitas aquáticas, sendo que houve maior riqueza de espécies das famílias: Araceae, Pontederiaceae, Salviniaceae, com 14 espécies registradas. As formas biológicas presentes foram flutuantes livre emersa (64%), herbácea fixa com caules flutuantes (22%), herbácea emergente e flutuante livre submersa com 7% cada. A similaridade de espécies foi de 50% entre as comunidades dos lagos. O presente estudo revela conhecimentos prévios e inéditos sobre características ecológicas das comunidades de macrófitas aquáticas na região amazônica, o que pode ser um primeiro passo para futuros projetos de conservação.
Survei Sarana Dan Prasarana Pendidikan Jasmani Sekolah Menengah Pertama Negeri Di Kabupaten Grobogan Tahun 2020
Authors: Nugraha Bintang Cahya , Yuwono Cahyo 
Published: July 2022

The purpose of this study was to determine the physical education facilities and infrastructure of State Junior High Schools in Grobogan Regency. This research used quantitative research methods. This reseacrh was a survey research. The variables of this study were physical education facilities and infrastructure. The research population questionnaire was taken from 10 State Junior High Schools in Grobogan Regency. The sample used saturated sampling and the sampling used the quota sampling technique. The subjects in this study were physical education teachers of State Junior High Schools in Grobogan Regency. The data analysis technique used descriptive analysis, the method analysis used quantitative descriptive analisis by classifying the types of data obtained from the observation sheet and grouped. The results of the research that have been conducted indicate that the state of the existing facilities and infrastructure of Junior High School in Grobogan Regency is still limited.
Comparative Analysis of Power switches MOFET and IGBT Used in Power Applications
Authors: Vanitha Dr. D. 
Published: July 2022

In this paper, deals with detailed analysis between MOSFET and IGBT. There always a race between MOSFET and IGBT in the power electronics markets. This paper will gives the complete details about them. This paper also discuss how they are used for various applications. By reading this paper any beginners who wants to need detailed analysis between IGBT and MOSGET they can get.
Proximate Composition and Fibre Fraction of Pearl Millet Fodder as Influenced by Different Nutrient Management Practices
Authors: Kumar Rakesh , Ram Hardev , Kumar Rakesh , Meena R.K. , Meena B.L. , . Manisha , Kumar Deepak 
Published: July 2022

Background: Quality traits of forage crops are largely influenced by various agronomic management practices at field conditions in different climatic strata. Judicious use of organic and inorganic sources of nutrients may sustain soil health, fodder productivity and quality. Keeping above facts in view an experiment was conducted for evaluation of nutrient management practices to increase fodder quality of pearl millet. Methods: The experiment was carried out during kharif season (2019-20) at Agronomy Research Farm, ICAR-NDRI, Karnal and laid out in randomized block design with eight treatments, viz., T1: Absolute control; T2: 100% RDF; T3: 100% RDF + Cow urine foliar spray; T4: 100% RDF + PGPR; T5: 100% RDF + PGPR + Cow urine foliar spray; T6: 75% RDF + Cow urine foliar spray; T7: 75% RDF + PGPR and T8: 75% RDF + PGPR + Cow urine foliar spray. Each treatment had three replications. Result: The results showed that the fodder proximate principles viz., dry matter, crude protein, ether extract and total ash content increase by 27.04, 21.33, 24.06 and 31.17% respectively, with T5 treatment than absolute control. The cell wall constituents such as neutral detergent fibre (63.99%), acid detergent fibre (39.50%) and acid detergent lignin (5.60%) were also lower in T5 treatment over the other treatments. It can be concluded that the fodder quality of pearl millet significantly better with application of T5 treatment, that was found statistically at par with T4 treatment. Which, will further strengthen and sustain the performance of livestock in terms of health and milk production.
Higher Temperature had Positive Effects on Seed Germination of Glycyrrhiza glabra under NaCl Stress
Authors: Dong Xinping , Zhao Zhilong , Ma Xia , Li Xiao , Ma Miao 
Published: July 2022

Background: Agricultural soils are affected by secondary salinization due to the fragile ecological environment and lack of scientific management. It is of interest to utilize the germplasm resources of salt-tolerant plants and improve their salinity stress resistance. Seed germination of the medicinal halophyte Glycyrrhiza glabra is affected by soil salt content and temperature during seeding. This study determined the favourable soil temperature for G. glabra seed germination in salinised soil. Methods: Four sodium chloride concentration gradients (control, hyposaline, medium-saline and hypersaline) and 3 temperatures (low- medium- and high temperature) were used for a total of 12 treatments; 30 seeds were utilised in each treatment and each treatment was repeated 3 times. Result: G. glabra seed germination indexes significantly decreased with increased salt concentration. Interestingly, higher temperature could improve the salt tolerance of seeds. Seed germination percentages of hyposaline, medium-saline and hypersaline treatments were higher at elevated temperature than those at low temperature by 33.53%, 127.1% and 41.7%, respectively and were higher than those at medium temperature by 14.1%, 121.6% and 54.6% respectively. Therefore, G. glabra seeds growing in saline habitats should be sown in summer. This study provided a scientific basis for medicinal plant cultivation in salinised soil.
Effect of PEG-simulated Drought Stress on Seed Germination of Three Medicinal Liquorice (Glycyrrhiza) Species
Authors: Hou Mingcai , Ma Miao 
Published: July 2022

Background: Glycyrrhiza is an important medicinal plant that has been in shortage in recent years because of high demand and exhaustive harvesting. Investigating the drought tolerance of liquorice species can inform the artificial cultivation of liquorice under different water conditions and help address the shortage. Methods: Seeds of G. uralensis, G. glabra and G. inflata were treated with different concentrations of polyethylene glycol (PEG)-6000 solutions to simulate different levels of drought stress. The germination process germination rate, germination index, vigour index, stress tolerance index and recovery germination percentage of seeds were measured. Drought tolerance was evaluated using the membership function. Result: Low concentrations of PEG promoted the seed germination of G. glabra and G. inflata, whereas high concentrations inhibited the seed germination of all three plants. The degree of inhibition increased with increasing PEG concentration. Under mild PEG stress, the drought tolerance of G. uralensis was highest and that of G. glabra was the lowest. However, under severe PEG stress, the drought tolerance of G. glabra was the highest and that of G. uralensis was the lowest. Therefore, seeds of G. uralensis should be sown in relatively moist soil and those of G. glabra in relatively arid soil.
Pelatihan Pembuatan Media Pembelajaran Elektronik untuk Guru SMK Lingua Prima
Authors: Nopriyanti Nopriyanti , Kurniawan Elfahmi Dwi , Darlius Darlius , Harlin Harlin 
Published: July 2022

Pengabdian Kepada Masyarakat (PKM) ini dilakukan di SMK Lingua Prima Indralaya dengan tema "Pelatihan Pembuatan Media Pembelajaran Elektronik untuk Guru SMK Lingua Prima". Kegiatan pelatihan ini dilakukan secara tatap muka dengan melaksanakan protokol kesehatan. Kegiatan ini bertujuan untuk membekali guru-guru SMK menggunakan aplikasi Canva yang membantu membuat media elektronik secara online. Selain itu, melalui pelatihan ini diharapkan guru mampu menghasilkan media elektronik yang kreatif dan inovatif.Kegiatan dilaksanakan pada tanggal 27-28 Oktober 2021 di SMK Lingua Prima. Peserta pelatihan berjumlah 21 guru SMK Lingua Prima. Kegiatan pelatihan guru SMK Lingua Prima terdiri dari kegiatan teori dan praktik. Indikator keberhasilan pelatihan ditandai dengan: (1) kemampuan para peserta untuk menginstal dan membuat akun Canva (2). Kemampuan peserta dalam membuat media elektronik berbasis Canva. Hasil yang didapatkan dari kegiatan pelatihan ini yaitu guru memiliki keterampilan menggunakan aplikasi canva untuk membuat media pembelajaran elektronik. Setelah pelatihan ini dilaksanakan terlihat dapat meningkatkan kemampuan guru dalam mengembangkan media pembelajaran yang kreatif dan inovatif. This Community Service was carried out at Lingua Prima Indralaya Vocational School with the theme "Training for Making Electronic Learning Media for Teachers of Lingua Prima Vocational School". This training activity is carried out face-to-face by implementing health protocols. This activity aims to equip SMK teachers to use the CANVA application, which helps create electronic media online. In addition, through this training, teachers are expected to be able to produce creative and innovative electronic media. The activity will be held on 27-28 October 2021 at Lingua Prima Vocational School. The training participants were 21 teachers of Lingua Prima Vocational School. The teacher training activities of Lingua Prima Vocational School consist of theoretical and practical activities. The indicators for the success of the training are: (1) the ability of the participants to install and create a Canva account (2). Participants' ability to create Canva-based electronic media. The results obtained from this training activity are that teachers have the skills to use the Canva application to create electronic learning media. After this training was carried out, it was seen that it could improve the ability of teachers to develop creative and innovative learning media.
Pelatihan Eco Printing bagi Masyarakat Desa Sungai Pandan Kecamatan Batu Ampar Kabupaten Kubu Raya
Authors: Trisianawati Eka , Dafrita Ivan Eldes , Sari Mustika , Sulistyani Henny , Herditya Herditya , Nawawi Nawawi 
Published: July 2022

Potensi alam desa Sungai Pandan, Kecamatan Batu Ampar Kabupaten Kubu Raya yang melimpah, belum optimal dimanfaatkan oleh warga masyarakat. Kelompok ibu-ibu PKK Desa Sungai Pandan masih membutuhkan keterampilan dalam mengelola potensi desa. Dalam rangka menciptakan masyarakat mandiri dengan memanfaatkan potensi dan keunggulan wilayah masing-masing secara bertahap dan berkelanjutan, maka program studi pendidikan biologi IKIP PGRI Pontianak mengadakan pelatihan Eco Printing yang diikuti 11 orang ibu-ibu PKK Desa Sungai Pandan. Metode pelaksanaan program PKM ini adalah sebagai berikut; 1) Persiapan, 2) Analisa kebutuhan mitra, 3) Perancangan Eco-printing, 4) Pelatihan Eco-Printing, 5) Evaluasi. Kegiatan dilaksanakan pada tanggal 10 Agustus 2021, Teknik Eco Printing digunakan dalam pelatihan adalah teknik pukul (pounding) yang diaplikasikan pada Toot Bag Kanvas. Peserta merasakan bahwa kegiatan pelatihan sangat bermakna dalam meningkatkan pengetahuan, dan dapat dikembangkan lagi untuk dapat dijual atau dipasarkan baik manual maupun secara online, sehingga kegiatan yang telah dilakukan dapat meningkatkan kesejahteraan warga di Desa Sungai Kupah melalui penjulan Toot Bag Kanvas. The community has not optimally utilized the abundant natural potential of Sungai Pandan Village, Batu Ampar District, Kubu Raya Regency. The group of PKK women in Sungai Pandan Village still needs skills in managing village potential. In order to create an independent community by utilizing the potential and advantages of each region gradually and sustainably, the Biology Education Study Program of IKIP PGRI Pontianak held an Eco Printing training attended by 11 PKK women from Sungai Pandan Village. The method of implementing this PKM program is as follows; 1) Preparation, 2) Analysis of partner needs, 3) Eco-printing design, 4) Eco-Printing Training, 5) Evaluation. In the activity carried out on August 10, 2021, the Eco Printing technique used in training was the pounding technique applied to the Canvas Toot Bag. Participants felt that the training activities were significant in increasing knowledge. They could be further developed to be sold or marketed both manually and online so that the activities carried out can improve the welfare of residents in Sungai Kupah Village through the sale of Canvas Toot Bags.
Pemberdayaan Anak Melalui Kegiatan Belajar, Bermain, dan Mngeksplorasi (BBM) dalam Meningkatkan Motivasi Belajar di Desa Ligarmukti
Authors: Hsb Akmal Rizki Gunawan , Hakim Alwi , Hambali Yoyo , Suprianto Agus 
Published: July 2022

: Proses pembelajaran formal maupun non-formal sama-sama memiliki hambatan belajar, seperti halnya motivasi belajar, media pembelajaran serta metode yang digunakan. Maka diperlukan kegiatan yang dapat menunjang serta menjadi pembeda bagi suasana kelas yang monoton dan kurang asik. Bersamaan dengan hal ini kemudian dilakukan sebuah upaya kegiatan, yang dinamakan kegiatan BBM (belajar, bermain dan mengeksplorasi) yang bertujuan untuk mendukung semangat serta menghilangkan kejenuhan belajar anak usia sekolah dasar, terutama anak di desa Ligarmukti. Metode yang digunakan dalam pengabdian masyarakat ini adalah action research, yang mana digunakan metode riset dalam pemecahan masalah, terjadi interaksi langsung antara penulis dan client dalam mencapai tujuan pengabdian. Kegiatan yang dilaksanakan pada 6-7 November 2021 ini membuahkan hasil, yaitu terjadi peningkatan motivasi belajar dalam diri anak. Hal itu dilihat dari antusias 85% dari 32 anak usia sekolah dasar untuk mengikuti kegiatan dengan semangat, mereka lebih aktif dalam mengemukakan pendapat, lebih interaktif atau tidak malu-malu. Both formal and non-formal learning processes have learning barriers, such as learning motivation, learning media and methods used. So we need activities that can support and be a differentiator for a monotonous and less cool class atmosphere. Simultaneously with this, an activity effort was then carried out, called the BBM activity (learning, playing and exploring) which aims to support enthusiasm and eliminate boredom in learning for elementary school age children, especially children in Ligarmukti village. The method used in this community service is action research, where research methods are used in problem solving, there is a direct interaction between the author and the client in achieving the goals of the service. The activity, which was held on 6-7 November 2021, yielded results, namely an increase in learning motivation in children. This can be seen from the enthusiasm of 85% of 32 elementary school age children to participate in activities with enthusiasm, they are more active in expressing opinions, more interactive or not shy.