bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic rate and climate change across latitudes: evidence of mass-dependent responses in aquatic amphipods
Authors: Shokri Milad , Cozzoli Francesco , Vignes Fabio , Bertoli Marco , Pizzul Elisabetta , Basset Alberto 
Published: November 2022

ABSTRACTPredictions of individual responses to climate change are often based on the assumption that temperature affects the metabolism of individuals independently of their body mass. However, empirical evidence indicates that interactive effects exist. Here, we investigated the response of individual standard metabolic rate (SMR) to annual temperature range and forecasted temperature rises of 0.6–1.2°C above the current maxima, under the conservative climate change scenario IPCC RCP2.6. As a model organism, we used the amphipod Gammarus insensibilis, collected across latitudes along the western coast of the Adriatic Sea down to the southernmost limit of the species' distributional range, with individuals varying in body mass (0.4–13.57 mg). Overall, we found that the effect of temperature on SMR is mass dependent. Within the annual temperature range, the mass-specific SMR of small/young individuals increased with temperature at a greater rate (activation energy: E=0.48 eV) than large/old individuals (E=0.29 eV), with a higher metabolic level for high-latitude than low-latitude populations. However, under the forecasted climate conditions, the mass-specific SMR of large individuals responded differently across latitudes. Unlike the higher-latitude population, whose mass-specific SMR increased in response to the forecasted climate change across all size classes, in the lower-latitude populations, this increase was not seen in large individuals. The larger/older conspecifics at lower latitudes could therefore be the first to experience the negative impacts of warming on metabolism-related processes. Although the ecological collapse of such a basic trophic level (aquatic amphipods) owing to climate change would have profound consequences for population ecology, the risk is significantly mitigated by phenotypic and genotypic adaptation.
Head Pain in the Competitive Aquatic Athlete—An Approach to a Differential Diagnosis and Management
Authors: Beduhn Benjamin , Roe Garrett , Furst Wendy , Lewno Adam 
Published: November 2022

Abstract
Aquatic athletes not only face common headache etiologies similar to the general population and land-based athletes but also experience their own unique pathology. Posture, aquatic pressure, equipment, and even marine animals pose as unique causes to head pain in the aquatic athlete. Common head pain pathologies seen in the aquatic athlete include tension-type headaches, migraines, cluster headaches, and compressive headaches, including supraorbital neuralgia. Creating a thorough but focused differential diagnosis for head pain in the aquatic athlete can be a difficult and overwhelming task for some. We review both the common and not-so-common etiologies of head pain in the aquatic athlete and suggest a simple framework for assessment and treatment to diagnose and treat head pain in this specific population.
Greater functional connectivity between the ventral frontal cortex and occipital cortex in herpes zoster patients than post-herpetic neuralgia patients
Authors: Li Jiahao , Gu Lili , Hong Shunda , Chen Yeyuan , Luo Qing , Wu Ying , Yang Jiaojiao , Xiong Jiaxin , Lv Huiting , Jiang Jian 
Published: November 2022

Objective:
This study aimed to compare whole brain network between herpes zoster (HZ) patients and post-herpetic neuralgia (PHN) patients, as well as to investigate the associations between whole brain network changes and pain intensity and the accuracy of classifying between different types of pain.

Methods:
PHN patients (n = 50) and HZ patients (n = 50) and healthy controls (HCs) (n = 50) underwent resting-state functional magnetic resonance imaging (rs-fMRI). Functional connectivity and global and local graph theory metrics were calculated by using Dosenbach-160 atlas. The relationship between neuroimaging indicators and clinical scales was evaluated using correlation analysis, and receiver operating characteristic (ROC) curves evaluated the feasibility of classifying PHN and HZ patients using specific neuroimaging indicators.

Results:
(1) 10 greater average connectivities were found in HZ group among the default mode, frontoparietal, cingulo-opercular, sensorimotor, occipital networks (ONs), and cerebellum (p &lt; 0.001). (2) HZ patients exhibited higher global efficiency than those in the PHN and HCs (t = 2.178, p = 0.038). (3) Multiple linear regression analyses indicated that functional connectivity between the ventral frontal cortex in the cingulo-opercular network and the occipital gyrus in the ON influenced the visual analog score pain scores (β = 4.273; p = 0.004).

Conclusion:
The variation of functional connectivity between ventral frontal cortex in the cingulo-opercular network and occipital gyrus in the ON may be a robust neuroimaging marker of the transition from HZ to PHN patients.

Advances in knowledge:
Whole-brain network analysis may be effective in distinguishing HZ and PHN patients and predicting pain intensity.
Systems Biology in ELIXIR: modelling in the spotlight
Authors: Martins dos Santos Vitor , Anton Mihail , Szomolay Barbara , Ostaszewski Marek , Arts Ilja , Benfeitas Rui , Dominguez Del Angel Victoria , Ferk Polonca , Fey Dirk , Goble Carole , Golebiewski Martin , Gruden Kristina , Heil Katharina F. , Hermjakob Henning , Kahlem Pascal , Klapa Maria I. , Koehorst Jasper , Kolodkin Alexey , Kutmon Martina , Leskošek Brane , Moretti Sébastien , Müller Wolfgang , Pagni Marco , Rezen Tadeja , Rocha Miguel , Rozman Damjana , Šafránek David , Sheriff Rahuman S. Malik , Suarez Diez Maria , Van Steen Kristel , Westerhoff Hans V , Wittig Ulrike , Wolstencroft Katherine , Zupanic Anze , Evelo Chris T. , Hancock John M. 
Published: November 2022

In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Community believes that the infrastructure aspects of systems biology - databases, (modelling) tools and standards development, as well as training and access to cloud infrastructure - are not only appropriate components of the ELIXIR infrastructure, but will prove key components of ELIXIR’s future support of advanced biological applications and personalised medicine. By way of a series of meetings, the Community identified seven key areas for its future activities, reflecting both future needs and previous and current activities within ELIXIR Platforms and Communities. These are: overcoming barriers to the wider uptake of systems biology; linking new and existing data to systems biology models; interoperability of systems biology resources; further development and embedding of systems medicine; provisioning of modelling as a service; building and coordinating capacity building and training resources; and supporting industrial embedding of systems biology. A set of objectives for the Community has been identified under four main headline areas: Standardisation and Interoperability, Technology, Capacity Building and Training, and Industrial Embedding. These are grouped into short-term (3-year), mid-term (6-year) and long-term (10-year) objectives.
Effect of Moringa oleifera leaf extract on salivary gland damage in Sjögren's syndrome mice model
Authors: Susanto Agus Joko , Purwanto Bambang , Mudigdo Ambar , Wasita Brian 
Published: November 2022

Background Sjögren's syndrome is a chronic autoimmune disease characterized by lymphocytic infiltration and inflammation of the exocrine glands, especially the lacrimal and salivary glands. Moringa oleifera (MO) leaves are rich in polyphenols and flavonoids which have antioxidant activity which is also shown when extracted with ethanol. This study aimed to probe the effect of Moringa oleifera leaf extract on malondialdehyde (MDA), interleukin-17 (IL-17), matrix metalloproteinase-9 (MMP-9), and caspase-3 levels and salivary gland damage in Sjögren's syndrome mice model. Methods Thirty-two samples were divided into four treatment groups: 200 mg/kg BW MO-ethanol leaf extracts with 1.23 mg/kg BW dexamethasone group (T2), 1.23 mg/kg BW dexamethasone alone group (T1), normal control group/C- (without induction of Ro antigen (SSA) and extract of MO-ethanol), and negative group/C+ (with induction of Ro antigen (SSA) on day 42). MDA, IL-17, MMP-9, and caspase-3 levels and salivary gland epithelium damage (histopathological changes) were measured 14 days post-Ro antigen (SSA) induction. The method used to measure MDA level was Thiobarbituric Acid Reactive Substance (TBARS) while IL-7 and MMP-9 were ELISA. Some of the salivary gland was used for histological preparations using the paraffin method withoud Harris Hematoxylin–Eosin (HE) staining. Then for the examination of caspase-3, we used the standard procedure of immunohistochemically staining. The salivary gland epithelium damage examination used the HE staining of histological preparation. Results There were significant differences in MDA, IL-17, MMP-9, and caspase-3 levels in the group given a 200 mg/kg BW dose of MO-ethanol leaf extract compared to the control group. The administration of the extract also significantly reduced the degree of necrosis of the salivary gland epithelium. Conclusions Moringa oleifera leaf extract reduced MDA, IL-17, MMP9, and caspase-3 levels and salivary epithelial damage.
Performance Characteristics and Efficiency Enhancement Techniques of Solar PV System: A review
Authors: Shalwar Prashant Kumar , Gupta Bhupendra , Bhalavi Jyoti , Bisen Anand 
Published: November 2022

In constant degradation of conventional sources and shifting fuel costs, has prompted research into alternate power generating options in recent years. A substantial study has been conducted in the literature to properly harvest power from green energy resources. This publication aims to provide a quick assessment of various PV Performance Characteristics on different factors (such as varying irradiation, temperature, parallel & series connection, tilt angle, shading, environment impact, and different type of PV modules), to bring all of the research activities in this field under one tent. This work resulted that the efficiency and performance of the PV system are greatly affected by module temperature, irradiation, shadow, and tilt angle. Hence, each of the characteristics of the solar PV module has been examined critically with reasons, remedies, and techniques applied. Finally, a concise review with enumerated data has been presented which lightened the pathway for new researchers working in Solar Photovoltaics.
THE INFLUENCE OF ELEMENTS OF PROGRESSIVE TECHNOLOGY ON THE YIELD AND QUALITY OF SPRING WHEAT GRAIN ON CHERNOZEM SOILS OF THE VOLGA REGION OF THE REPUBLIC OF TATARSTAN
Authors: Serzhanov Igor , Shaykhutdinov Farit , Serzhanova Al'bina , Garaev Razil , Zalyalov Ranis 
Published: November 2022

The article presents the results of two-year experiments (2020-2021) conducted in the conditions of Volga region of the Republic of Tatarstan. The effect of mineral fertilizers on the content of the mass fraction of gluten and protein in wheat grain was studied. The productivity and grain quality of several wheat varieties included in the State Register for the 7th region were compared when using fertilizers at a dose of N10-14P24-26K16-37 and chemical plant protection products. It was found that from the application of fertilizers and the use of the plant protection unit, an increase in grain yield for the studied varieties was obtained from 0.32-0.92 t/ha compared with the control. The field experiment was conducted in LLC Avangard of Buinsky district of the Republic of Tatarstan. The soil is leached chernozem and has the following agrochemical characteristics: humus content – 7.0-8.5%, mobile forms of phosphorus – 182-255 mg/kg, potassium – 159-193 mg/ kg and salt pH – 5.5-5.8.
Agrochemical analyses of soils were performed in Federal State Budgetary Institution “Tatarskiy” by generally accepted methods: GOST 26213-91 (humus content), GOST 26484-85 (pHsol.), GOST 26207-91 (mobile forms of phosphorus and potassium).
Meteorological conditions in 2020 were characterized by sufficient soil moisture and a moderate temperature regime during the growing season of spring wheat (GTK-1.28) and had a positive impact on the value of the future harvest.
Meteorological indicators for the growing season of the research object in 2021 were extremely unfavorable for the formation of the crop. May and June were acutely arid, GTC-0.27. The precipitation in July (57% of the norm) did not have a significant impact on the formation of the spring wheat crop. From the application of fertilizers and the use of plant protection products, an increase in grain yield for the studied varieties from 0.32 to 0.92 t/ha was obtained compared to the variant without fertilizers and plant protection products. Improving the nutritional conditions of plants by applying mineral fertilizers led to an increase in the protein content of spring wheat grains and the protein content was 0.6 ... 0.8 higher, depending on the varietal characteristics of spring wheat, than on an unfertilized background. Under the conditions of chernozem soils of the Pre-Volga zone of the Republic of Tatarstan, the best results over the years of research were obtained in variants where the application of mineral fertilizers was combined with the use of plant protection products of such spring wheat varieties as Yoldyz, Burlak and Ekada 109. In the same variants, the highest protein content was noted in grain. The use of chemical protection against the background of mineral fertilizers in the varieties Yoldyz, Burlak, Ekada109 contributed to a significant increase in the gross collection of protein per unit area.
Datenmarktplätze für Künstliche Intelligenz im Gesundheitswesen: Potenziale, Herausforderungen und Strategien zur Bewältigung
Authors: Guse Richard , Thiebes Scott , Hennel Phil , Rosenkranz Christoph , Sunyaev Ali 
Published: November 2022

ZusammenfassungDas Training von Künstliche Intelligenz (KI)-Modellen, die auf maschinellem Lernen (ML) beruhen, erfordert eine große Menge qualitativ hochwertiger Daten. Besonders im Gesundheitswesen mit seinen hochsensiblen Daten und hohen Anforderungen an den Datenschutz besitzen einzelne Akteur:innen oft jedoch nicht ausreichend hochwertige Daten. Datenmarktplätze für KI zielen darauf ab, dieses Problem zu lösen, indem sie Datenanbieter und Datenkonsumenten miteinander verbinden und den Handel von Daten ermöglichen. Allerdings haben sich Datenmarktplätze im Gesundheitswesen, trotz erster technischer Konzepte und einiger Pilotprojekte, bisher noch nicht erfolgreich durchsetzen können. Im Rahmen der vorliegenden Studie wurden daher Interviews mit einer Reihe von relevanten Expert:innen und Akteur:innen durchgeführt, um Potenziale, Herausforderungen und mögliche Strategien zur Bewältigung der Herausforderungen zu identifizieren. Die Ergebnisse der Studie verdeutlichen anhand der drei Dimensionen des Technology-Organization-Environment-Frameworks spezifische Potenziale von Datenmarktplätzen für KI im Gesundheitswesen, aber gleichzeitig auch eine Reihe von Herausforderungen, die es zu adressieren gilt. Die erarbeiteten Bewältigungsstrategien liefern hierbei erste Ansätze zur Beseitigung der identifizierten Herausforderungen, zeigen jedoch auch die Notwendigkeit der weiteren Forschung auf diesem Gebiet auf.
Knowledge of risk and protective factors for dementia in older German adults A population-based survey on risk and protective factors for dementia and internet-based brain health interventions
Authors: Zülke Andrea E. , Luppa Melanie , Köhler Sebastian , Riedel-Heller Steffi G. 
Published: November 2022

Background
Evidence on potentially modifiable risk factors for dementia is accumulating rapidly, including e.g. physical inactivity, hypertension, or diabetes. It is unclear to what extent these risk factors are known among the general population in Germany. We investigated knowledge on risk and protective factors for dementia and openness to eHealth interventions for brain health in the older general population in Germany.

Methods
A population-based telephone survey among randomly selected community-dwelling adults aged ≥ 60 years was conducted. We assessed sociodemographic factors, knowledge on risk and protective factors for dementia, openness towards eHealth and psychosocial outcomes (health literacy, resilience). Factors associated with interest in information on brain health and openness towards eHealth interventions were assessed using multivariable logistic regression.

Results
Of n = 500 respondents (mean age: 74.8 years, % female: 62.8), 67.9% believed that dementia risk is modifiable. Participants mostly endorsed physical and cognitive activity as protective factors and social isolation as a risk factor. Knowledge on cardiovascular risk factors was low to moderate. 38.0% were interested in information on dementia risk reduction. Better knowledge of risk factors for dementia and higher age were linked to interest in information on brain health. Being widowed and higher levels of health literacy were associated with lower interest in information. Openness to eHealth interventions was moderate (46.2%). Younger age, better knowledge of risk and protective factors were linked to openness towards eHealth tools, as was knowing someone with dementia and interest in information on brain health.

Conclusion
Belief in preventability of dementia was higher in our sample than previously reported. However, knowledge on cardiovascular risk factors for disease was insufficient and more information and intervention approaches targeted at older adults are needed. Interest in information on dementia risk reduction and eHealth approaches was moderate, and further studies are warranted to assess needs and concerns of older adults regarding dementia prevention.
Health-seeking behaviours of young women with sexually transmitted infections: Analysis of the 2014 Ghana Demographic and Health Survey
Authors: Abuosi Aaron Asibi , Ackon Solomon Kwesi , Anaba Emmanuel Anongeba 
Published: November 2022

Background
Young people are at a disproportionately higher risk for sexually transmitted infections (STIs) due to biological factors, low awareness and limited access to sexual and reproductive health information and services. Untreated STIs can lead to major complications, including HIV, congenital infections, infertility, permanent disability and mortality. This study aimed to identify the salient factors associated with health-seeking behaviours of young women with a history of STIs in Ghana.

Methods
We analysed data from the 2014 Ghana Demographic and Health Survey. In all, we analysed data from a weighted sample of 742 young women with a history of STIs. At the univariate level, frequencies and percentages were computed, while Chi-square analysis was computed at the bivariate level. Both crude and adjusted odds ratios were computed at the multivariable level using binary logistic regression.

Results
The findings showed that the majority (72%) of the participants sought treatment for STIs. Among the participants who sought treatment for STIs (n = 532), 26% sought treatment at a public hospital/polyclinic, 34% sought treatment at a chemical/drug store and 10% self-medicated. Seeking treatment for STIs was significantly associated with older age (20-24yrs), and higher socioeconomic and educational status.

Conclusion
This study demonstrated that majority of the young women sought treatment for STIs. Seeking treatment for STIs was influenced by socio-demographic factors. These findings have implications for sexual and reproductive health policies and interventions in Ghana.
Donohue syndrome and use of continuous subcutaneous IGF1 pump therapy
Authors: Melikyan M. A. , Ivannikova T. E. , Milovanova N. V. , Kolodkina A. A. , Bezlepkina O. B. , Mokryshevа N. G. 
Published: November 2022

Donohue syndrome (DS), also called Leprechaunism, is the most severe form of insulin resistance associated with biallelic mutations in INSR gene (OMIM: 147670). The approximate incidence of this syndrome is 1 per 1000000 births. Patients are present with typical clinical features such as intrauterine growth retardation, facial dysmorphism, severe metabolic disturbances, hepatomegaly and hypertrophic cardiomyopathy. Most DS patients die within the first two years of life due to respiratory infections, severe hypoglycemia or progressive cardiomyopathy. Treatment options are limited and no specific therapy exist for DS. Given the similarities between insulin and insulin-like growth factor 1 (IGF-1) receptors, recombinant human IGF-1 (rhIGF-1) has been used to treat severe insulin resistance including DS.We report the case of a male patient with genetically confirmed Donohue syndrome, successfully treated with continuous subcutaneous IGF1 infusion via insulin pump. We observed improvement of glycemic control, liver function and cardiac hypertrophy regression following 15-month IGF1 therapy.
Primary hypothyroidism and postmenopause as the causes of delayed diagnosis of panhypopituitarism in a patient with nonfunctional pituitary adenoma
Authors: Ryzhkova E. G. , Ladygina D. O. 
Published: November 2022

Hypopituitarism is a state of complete or partial deficiency of pituitary hormones, including adrenal insufficiency, hypothyroidism, hypogonadism, growth hormone deficiency, and, rarely, diabetes insipidus.The article describes a clinical case of hypopituitarism due to a pituitary tumor in a postmenopausal woman. Difficulties in diagnosing hypopituitarism were due to a history of primary hypothyroidism. The first identified component of panhypopituitarism in the patient, (central hypothyroidism) had previously been seen as laboratory indications of medication-induced hyperthyroidism.The non-specific nature of the clinical symptoms, as well as a relatively rare combination of endocrine diseases, led to a long examination period and delayed diagnosis of the pituitary tumor.Whether the development of hypopituitarism in a patient with a nonfunctional pituitary tumor is an indication for transsphenoidal pituitary surgery remains a controversial issue. The decision for surgery is made taking into account the characteristics of the course of the disease in a particular patient. In this clinical case, a conservative tactic was chosen with hormone replacement therapy for glucocorticoid and thyroid deficiency.