bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoma of Unknown Primary Origin: Application of Immunohistochemistry With Emphasis to Different Cytokeratin 7 and 20 Staining Patterns
Authors: Mokhtari Maral , Safavi Dornaz , Soleimani Neda , Monabati Ahmad , Safaei Akbar 
Published: August 2022

Background:
Although the primary origin of some carcinomas may be obscure to clinicians, its identification is crucial as it affects prognosis and treatment (especially novel targeted therapies). Immunohistochemistry (IHC) may be helpful in identifying the primary origin of carcinomas. This retrospective survey aimed to evaluate the frequency and accuracy of each IHC marker used to determine the origin of carcinomas.

Methods:
The review of pathology department archives revealed 307 cases of cancer of unknown primary origin (CUP) between 2015 and 2020, which were accessible in the department archives. Demographic information, site of biopsy, clinical and pathologic diagnoses, and IHC results of the patients were collected.

Results:
The patients included 157 (51.15%) men and 150 (48.85%) women. The age of the patients ranged from 14 to 92 years, including 106 (34.5%) expired cases. In 27% of cases, the primary origin of carcinoma remained unknown. The agreement between pathologic and clinical diagnoses was 59%. The most common pattern of cytokeratin (CK) expression in CUP was CK7+/CK20- (55.3%), followed by CK7-/CK20- (19%), CK7+/CK20+ (15%), and CK7-/CK20+ (10.7%), respectively.

Conclusion:
The IHC analysis may improve the diagnosis of CUPs. However, the origin of some cases remains unknown despite an IHC analysis, thereby necessitating the use of more diagnostic procedures or gene expression studies for reaching a definitive diagnosis.
Impact of PPAM aid use on the time to prosthetic limb delivery in patients with unilateral transtibial amputation: A retrospective analysis
Authors: Lee Julia , Davie-Smith Fiona , Hebenton Joanne , Sharp Kath , Seenan Chris 
Published: August 2022

Background:
The pneumatic postamputation mobility (PPAM) aid is the most commonly used early walking aid in the United Kingdom in transtibial amputation (TTA) and promotes wound healing and prepares the stump for prosthetic limb fitting. Optimal guidelines for PPAM aid use and how these factors affect achievement of rehabilitation milestones have not yet been conclusively established.

Objective:
To investigate the relationship between PPAM aid use and the time taken to achieve rehabilitation milestones in patients undergoing unilateral TTA.

Study design:
Retrospective case note analysis.

Methods:
Case notes of patients from one National Health Service amputation rehabilitation center who were identified as having a unilateral TTA in 2017–2018 and fitted with a prosthesis were reviewed.

Results:
One hundred seven patients (67.5% male; mean age of 59.9 years) were identified. Use of PPAM aid during inpatient physiotherapy was associated with the days to reach referral, casting, delivery of prosthetic limb, and inpatient discharge dates (r (105) =−0.345; −0.400; −0.423; 0.546, respectively, all P < 0.05). Frequency of PPAM aid use was associated with the time to reach casting (r (105) =−0.533, P < 0.05) and delivery (r (105) =−0.513, P < 0.05). The days to being PPAM aid use and the frequency of PPAM aid use were predictive of the days to reach referral, casting, delivery, and inpatient discharge.

Conclusions:
The use of the PPAM aid is associated with a reduction in the time taken to reach rehabilitation milestones. Early and more frequent use of PPAM aid during rehabilitation will decrease the time fit and delivery of the prosthetic limb.
Validity and reliability of Turkish transcultural adaptation of the Prosthetic Limb Users Survey of Mobility
Authors: Yosmaoglu Sevgin , Yazicioglu Gul , Demir Yasin , Aydemir Koray , Yosmaoğlu Hayri Baran 
Published: August 2022

Background:
Amputee-specific, self-assessment mobility scales are essential to evaluate mobility in lower-limb amputees.

Objectives:
To evaluate the validity and reliability of a Turkish translation and adaptation of the Prosthetic Limb Users Survey of Mobility.

Study design:
This is a validation study.

Methods:
Turkish translation of the Prosthetic Limb Users Survey of Mobility (PLUS-M-T) from its original was performed following the rules of intercultural adaptation and translation methods. The PLUS-M-T and its 12-item short form were applied to '100 induviduals with limb loss twice in 3-day intervals. The structural validity analysis was determined by calculating the correlation with the Amputee Mobility Scale, which is a valid, reliable scale for assessing the functional level in amputees. The Cronbach alpha coefficient was calculated to analyze the internal consistency. The interclass correlation coefficient (ICC) and Spearman correlation coefficient (r) were calculated, and the test–retest reliability was determined.

Results:
A positive, high correlation was found between the first application and its repetition of both PLUS-M-T (ICC = 0.85, r = 0.94, P < 0.001) and 12-item short form (ICC = 0.92, r = 0.93, P < 0.001). The internal consistency was high for both PLUS-M-T (Cronbach alpha = 0.94) and 12-item short form (Cronbach alpha = 0.91). A positive, high correlation was found between the scores obtained from the Amputee Mobility Scale and PLUS-M-T (r = 0.84, P < 0.001) and 12 question short form (r = 0.77, P < 0.001).

Conclusion:
Turkish translation of the PLUS-M questionnaire is a valid and reliable scale for assessing the mobility of individuals who have undergone lower-extremity amputation using a prosthesis.
Feasibility of repeated session error-augmentation gait training for people with nontraumatic transtibial amputation
Authors: Kline Paul W. , Davis-Wilson Hope C. , So Noel F. , Fields Thomas T. , Christiansen Cory L. 
Published: August 2022

Background:
Spatiotemporal gait asymmetries are a persistent problem for people with non-traumatic lower-limb amputation. To date, there is limited knowledge of multi-session gait training interventions targeting step length symmetry after non-traumatic amputation.

Objective:
The objective was to evaluate the feasibility and efficacy of an eight-session, treadmill-based error-augmentation gait training (EAT) protocol to improve spatiotemporal gait asymmetry in people with non-traumatic transtibial amputation (TTA).

Study Design:
Pre-post, single group. Methods: The EAT protocol involved eight training sessions (twice per week, four weeks) of supervised split-belt treadmill walking with asymmetrical belt speeds for five, three-minute sets each session. Step length symmetry during overground walking at a self-selected gait speed was assessed prior to, weekly, and one-week after the EAT protocol. Feasibility outcomes included protocol fidelity, safety, participant acceptability, and efficacy.

Results:
Seven of the eight participants (87.5%) completed the intervention at the prescribed dose. One participant developed a skin blister on their residual limb, which was possibly related to the intervention. No falls, musculoskeletal injuries, or increases in pain occurred. Participants rated EAT as acceptable based on scores on the Intrinsic Motivation Inventory – Interest/Enjoyment subscale (6.6 ± 0.5; mean ± SD). Average between-limb step length Normalized Symmetry Index improved (was reduced) one-week following EAT (2.41 ± 6.6) compared to baseline (5.47 ± 4.91) indicating a moderate effect size (d=0.53).

Conclusions:
An eight session EAT program delivered over four weeks using a split-belt treadmill is feasible for people with unilateral non-traumatic TTA and may reduce step length asymmetry up to a week after intervention.
Evaluation and Prediction of Healing Morphology After Closed Reduction for Unilateral Mandibular Condyle Fractures
Authors: Abe Shigehiro , Kobayashi Tatsuro , Yokomizo Naoko , Hyodo Katsuya , Kitano Hisataka , Kobayashi Yutaka 
Published: August 2022

Although closed reduction is common for condylar fractures, bone fragments may heal improperly. This study aimed to investigate the healing morphology of unilateral condylar fractures. We retrospectively investigated 70 patients with unilateral condylar fractures. Clinico-statistical analyses were performed on the whole-condylar fracture, closed reduction, and observation/functional therapy groups. Among these patients, 52 patients aged older than 16 years underwent closed reduction. The extent of maximum mouth opening, the incidence of malocclusion, and the relationship between healing morphology and Arbeitsgemeinschaft für Osteosynthesefragen classification or trismus were analyzed in the closed reduction group. There were significant differences in age (P=0.008) and sex (P=0.025) between the closed reduction and observation/functional therapy groups. However, there were no significant differences in trauma etiologies and concomitant fractures between the 2 groups. The average maximum mouth opening extent for unilateral fractures after closed reduction was 42.6±6.1 mm. Only 1 case (2.1%) of post-treatment malocclusion was observed. In all the MacLennan classification of deviation or more, regardless of the classification, upper fractures (head and upper neck) tended to heal through a spherical (P<0.001) morphology, whereas lower fractures (lower neck and subcondylar) tended to heal through an L-shaped and lateral fusion (P<0.001). There was no significant difference in the incidence of trismus between the healing morphology of unchanged type and others (P=0.690). Our results elucidated the etiology, dysfunction, and healing morphology classification of unilateral mandibular condyle fractures treated with closed reduction.
Examination of drinking motives during the pandemic: mediating effects of drinking motives in the relationship between impulsivity and alcohol use
Authors: Dinc Linda , Marzetti Jemma 
Published: August 2022

Purpose
Previous research have shown that individuals with high trait impulsivity are at high risk of engaging in problem alcohol use and that drinking motives differentially predicted alcohol use and problems. This study aimed to investigate whether these previously shown associations still existed during the global outbreak of the pandemic, COVID-19, which resulted in a long period of lockdown and raised concerns about the effects of alcohol.

Design/methodology/approach
The data was collected from 185 adults between ages of 18 and 35 during the lockdown period (November 20–May 21) through an online survey. Participants completed an impulsivity questionnaire, drinking motives and alcohol use measures.

Findings
The results revealed that enhancement and coping motives mediated the effects of positive and negative urgency, respectively, and lack of premeditation facet of impulsivity was directly linked to alcohol use. These findings are partially in line with the previous studies before the lockdown.

Research limitations/implications
Overall, individuals with particularly high urgency and premeditation maybe at high risk for problem alcohol use and may require tailored support for regulating emotions, particularly during stressful life events such as a global pandemic.

Practical implications
Findings may inform prevention and intervention strategies. Individuals with high trait urgency may benefit from more adaptive coping strategies such as learning specific emotion regulation strategies to minimise engaging in risk behaviours in stressful situations.

Originality/value
Findings suggest that traits positive and negative urgency are risk factors for alcohol use through enhancement and coping motives respectively, and these associations are particularly strong during stressful life events.
From curiosity to innovativeness: the mediating mechanisms of cultural intelligence and knowledge sharing behaviour
Authors: Chen Angela Shin-yih , Bian Min-dau , Nguyen Trung Kim , Chang Chien-Hua 
Published: August 2022

PurposeThis study aimed to examine the effects of curiosity on expatriates' innovative work behaviour and job satisfaction in a cross-cultural setting, with the sequential mediating effects of cultural intelligence (CQ) and knowledge-sharing behaviour.Design/methodology/approachData were collected by distributing an online survey to 465 Taiwanese expatriates living and working abroad. Structural equation modelling was used to test the hypotheses via AMOS v.22.FindingsThe results indicate that curiosity is an antecedent of an individual's CQ and both CQ and knowledge-sharing behaviour are sequential mediators in the relationships between curiosity and innovative work behaviour and between curiosity and job satisfaction.Originality/valueThe study expands the existing body of research to analyse personal traits as meaningful factors that enhance CQ and the mechanisms of CQ and knowledge sharing behaviour in the relationship between curiosity and innovative work behaviour and between curiosity and job satisfaction. It offers novel empirical evidence for the important role of curiosity, CQ and knowledge-sharing behaviour in enhancing an individual's innovative work behaviour and job satisfaction in a cross-cultural setting.
Impact of internal governance mechanisms on tax aggressiveness: evidence from French firms listed on the CAC 40
Authors: Menchaoui Ines , Hssouna Chaima 
Published: August 2022

PurposeThis study aims to analyze the relationship between a firm’s use of aggressive tax planning and board of directors (independence and size) and audit committee characteristics (independence and expertise).Design/methodology/approachThis study used archival data from 35 non-financial firms’ French firms listed on the CAC 40 over a period of 5 years (2013–2018).FindingsThis study shows that measures of board size are negatively related to tax aggressiveness. A broader board helps reduce tax aggressiveness, as having more members can improve board performance. Indeed, more members can contribute to a better assessment of tax risks and detect risky tax strategies.Research limitations/implicationsThe main limitation of this study is the small sample. The authors limited the observations to 2018 because the corporate tax rate in France changed in 2019. Such a time window casts homogeneity on the current study. Examining universal registration documents, it has been noted that companies have only recently become interested in disclosure of tax risk.Practical implicationsKnowing the characteristics of the board and audit committees can give a signal to stakeholders about the potential risk bearing on aggressive tax planning. This study provides evidence that could help the board governance committees integrate the right profiles and to raise awareness among the members of the board of directors and the audit committee to play their role (monitoring function or advisory function) about tax risk management.Originality/valueAccording to the authors’ knowledge, this study is the first to provide empirical evidence regarding the effect of the board of directors and audit committee characteristics on tax aggressiveness.
Identifying the potential participation in natural disaster insurance: first attempt based on a national socio-economic survey in Indonesia
Authors: Oktora Siskarossa Ika , Wulansari Ika Yuni , Siagian Tiodora Hadumaon , Laksono Bagaskoro Cahyo , Sugiandewi Ni Nyoman Ria , Anindita Nabila 
Published: August 2022

Purpose
This study aims to identify the regions with a high risk of natural disaster, estimate the proportion of households potentially participating in natural disaster insurance and analyze the relationship between disaster risk index and proportion of household potentially participating in natural disaster insurance.

Design/methodology/approach
Descriptive and quadrant analysis was applied on the 2019 Indonesia Disaster Risk Index (IRBI) scores and the 2019 National Socio-Economic Survey data.

Findings
The results showed there are only two categories of disaster risks in Indonesia based on IRBI categorization: “Medium” and “High.” Some districts in Aceh Province such as Simeuleu, Pidie Jaya and Banda Aceh City were observed to have a high proportion of households potentially participating in the natural disaster insurance while some in Jawa Tengah provinces have fairly low level even though they were categorized as high disaster-prone areas. Moreover, the quadrant analysis showed that 43 districts have high IRBI scores but low insurance participation rates with most discovered to be in Jawa Barat and Sumatera Selatan provinces.

Originality/value
Indonesia does not have a financial mitigation program up to the present time because almost all disaster resolutions are formulated based on emergency funds from the state budget even though it is important to use insurance schemes in all stages of disaster management. To the best of the authors’ knowledge, this study is the first attempt to identify households potentially participating in natural disaster insurance through the National Socio-Economic Survey in Indonesia.
Conducting a PhD as a project: sharing insights from my doctoral journey
Authors: Brunet Maude 
Published: August 2022

PurposeThe aims of this paper are to mobilize project management concepts in order to draw parallels with the doctoral project and to share the author’s experience and lessons learned.Design/methodology/approachThis paper is based on a qualitative inquiry using an autoethnographic approach.FindingsThis paper contributes a self-reflexive examination of the doctoral project experience that incites current and future doctoral students and early-career researchers to take advantage of opportunities that make the experience satisfying, lay the foundations of an academic career and help ensure the thesis is completed in a timely and orderly manner.Originality/valueExamining the doctoral project through the lens of one of the highest standards in project management, developed by the Project Management Institute (PMI), this paper enables PhD students in project management and other fields of study to understand the basics of a project and take action to structure their doctoral journey in a way that enhances both their experience and chances of success.
Institutional distance and Chinese investment efficiency in Africa: a stochastic frontier analysis
Authors: Mohamued Elyas Abdulahi , Khan Muhammad Asif , Meyer Natanya , Popp József , Oláh Judit 
Published: August 2022

PurposeThis study aims to analyse the efficiency effects of institutional distance on Chinese outward foreign direct investment (FDI) in Africa.Design/methodology/approachThe study utilised the true fixed-effect stochastic frontier analysis (SFA) model. Data from 2003 to 2016 (14 years) were acquired from 42 targeted African countries, which are included in the analysis.FindingsThe results reveal that FDI flow efficiency can be maximised with a high institutional distance between China and African countries. Contrariwise, comparable institutional distance, measured by the rule of law, regulatory quality and government effectiveness between the host and home countries, reflected a significant positive impact for Chinese outward foreign direct investment (OFDIs), indicating Chinese MNEs can invest directly in a country with comparable institutional characteristics.Originality/valueThere have been limited exceptional studies that assessed the effect of institutional distance between emerging countries. However, none of these studies investigated the effect of institutional distance between China and Africa at a national level. Using the advantage of the SFA model, this study assesses the efficiency effects of institutional distance between the host and home country.
Waqf integrated income generating model (WIIGM) for enhancing sustainable development goals (SDGS) in Malaysia: an evaluation of behavioural intention
Authors: Ibrahim Siti Sara , Daud Dalila , Hidayah Khusnul , Shaharuddin Amir , Al-Amin Al-Amirul Mukmin 
Published: August 2022

Purpose
This study aims to examine how beliefs and expectations on collaboration for investment, technology advancement and governance can lead to sustainable income generation that succeeds in influencing the community to accept the proposed Waqf integrated income generating model (WIIGM).

Design/methodology/approach
This study empirically examined the beliefs and expectations on the proposed WIIGM model, which was adapted from the theory of reasoned action (TRA). Data was collected from 366 respondents selected via convenience sampling. Questionnaires were distributed online, of which responses were then analysed using partial least squares structural equation modelling for hypothesis testing. Ethical approval is also gathered before the data collection begins.

Findings
This study found that collaboration for investment and governance significantly contribute to sustainable income generation in waqf operations and management, which eventually results in the community’s trust and acceptance of the WIIGM model. Technology advancement also significantly influences sustainable income generation, which finally leads to the community's behavioural intention to participate in the WIIGIM model. Further studies on this variable may establish findings from other perspectives.

Practical implications
This paper is an original study that empirically examines the potential for a new waqf integrated income-generating model in building the trust of the community towards waqf institutions. This study is significantly important for practitioners and policymakers in evaluating the potential roles of waqf based on the belief and trust of the community.

Originality/value
This paper adds value to existing literature regarding the potential of a new waqf integrated income-generating model.
Enhanced gray wolf optimization for estimation of time difference of arrival in WSNs
Authors: E. Devika , A. Saravanan 
Published: August 2022

Purpose
Intelligent prediction of node localization in wireless sensor networks (WSNs) is a major concern for researchers. The huge amount of data generated by modern sensor array systems required computationally efficient calibration techniques. This paper aims to improve localization accuracy by identifying obstacles in the optimization process and network scenarios.

Design/methodology/approach
The proposed method is used to incorporate distance estimation between nodes and packet transmission hop counts. This estimation is used in the proposed support vector machine (SVM) to find the network path using a time difference of arrival (TDoA)-based SVM. However, if the data set is noisy, SVM is prone to poor optimization, which leads to overlapping of target classes and the pathways through TDoA. The enhanced gray wolf optimization (EGWO) technique is introduced to eliminate overlapping target classes in the SVM.

Findings
The performance and efficacy of the model using existing TDoA methodologies are analyzed. The simulation results show that the proposed TDoA-EGWO achieves a higher rate of detection efficiency of 98% and control overhead of 97.8% and a better packet delivery ratio than other traditional methods.

Originality/value
The proposed method is successful in detecting the unknown position of the sensor node with a detection rate greater than that of other methods.