bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Outcomes of Cases of Children and Adolescents With Pediatric Inflammatory Multisystem Syndrome in a Tertiary Care Center in Mexico City
Authors: Gil Guevara Ricardo , Marroquín Yáñez María de Lourdes , Jiménez-Juárez Rodolfo Norberto , Olivar Lopez Víctor , Chávez Lopez Adrián , Sienra Monge Juan José Luis , Jamaica Balderas Lourdes Maria del Carmen , Martínez Herrera Silvia Alexandra , Domínguez-Barrera Clemen , Erdmenger Orellana Julio , Márquez González Horacio , Klünder-Klünder Miguel , Nieto Zermeño Jaime , Villa Guillen Mónica , González García Nadia , Castilla-Peon Maria F. 
Published: May 2022

BackgroundPediatric inflammatory multisystem syndrome (PIMS) is a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that resembles Kawasaki syndrome and places them at high risk of cardiorespiratory instability and/or cardiac damage. This study aims to describe the clinical presentation and outcomes of patients with PIMS in Mexico City.MethodsThis was an observational study of children hospitalized for PIMS based on the Centers for Disease Control and Prevention case definition criteria, in a single tertiary care pediatric center in Mexico City between May 1, 2020, and September 30, 2021. Demographic characteristics, epidemiological data, medical history, laboratory tests, cardiologic evaluations, treatment, and clinical outcomes were analyzed.ResultsSeventy-five cases fulfilled the case definition criteria for PIMS [median age: 10.9 years, Interquartile range (IQR): 5.6–15.6]. Fifteen (20%) patients had a severe underlying disease, 48 (64%) were admitted to the intensive care unit, 33 (44%) required invasive mechanical ventilation and 39 (52%) received vasopressor support. The patients were clustered through latent class analysis based on identified symptoms: Cluster 1 had rash or gastrointestinal symptoms (n = 60) and cluster 2 were those with predominantly respiratory manifestations (n = 15). Two patients (2.7%) died, and both had severe underlying conditions. Five patients (6.7%), all from cluster 1, developed coronary aneurysms.ConclusionThere were a high proportion of patients with severe respiratory involvement and positive RT-PCR SARS-CoV-2 and very few cases of coronary aneurysms in our study which suggests that a high proportion of the children had severe acute COVID-19. The clinical manifestations and outcomes are comparable to previously reported international studies.
The Fragility Index of Randomized Controlled Trials for Preterm Neonates
Authors: Li Huiyi , Liang Zhenyu , Meng Qiong , Huang Xin 
Published: May 2022

BackgroundAs a metric to determine the robustness of trial results, the fragility index (FI) is the number indicating how many patients would be required to reverse the significant results. This study aimed to calculate the FI in randomized controlled trials (RCTs) involving premature.MethodsTrials were included if they had a 1:1 study design, reported statistically significant dichotomous outcomes, and had an explicitly stated sample size or power calculation. The FI was calculated for binary outcomes using Fisher’s exact test, and the FIs of subgroups were compared. Spearman’s correlation was applied to determine correlations between the FI and study characteristics.ResultsFinally, 66 RCTs were included in the analyses. The median FI for these trials was 3.00 (interquartile range [IQR]: 1.00–5.00), with a median fragility quotient of 0.014 (IQR: 0.008–0.028). FI was ≤ 3 in 42 of these 66 RCTs (63.6%), and in 42.4% (28/66) of the studies, the number of patients lost to follow-up was greater than that of the FI. Significant differences were found in the FI among journals (p = 0.011). We observed that FI was associated with the sample size, total number of events, and reported p-values (rs = 0.437, 0.495, and −0.857, respectively; all p &lt; 0.001).ConclusionFor RCTs in the premature population, a median of only three events was needed to change from a “non-event” to “event” to render a significant result non-significant, indicating that the significance may hinge on a small number of events.
A Novel Immune-Prognosis Index Predicts the Benefit of Lung Adenocarcinoma Patients
Authors: Bai Yuquan , Pei Yun , Xia Liang , Ma Lin , Deng Senyi 
Published: May 2022

Background: Constructed an immune-prognosis index (IPI) and divided lung adenocarcinoma (LUAD) patients into different subgroups according to IPI score, describe the molecular and immune characteristics of patients between different IPI subgroups, and explore their response to immune checkpoint blockade (ICB) treatment.Methods: Based on the transcriptome profile of LUAD patients in TCGA and immune gene sets from ImmPort and InnateDB, 15 hub immune genes were identified through correlation and Bayesian causal network analysis. Then, IPI was constructed with 5 immune genes by using COX regression analysis and verified with external datasets (GSE30219, GSE37745, GSE68465, GSE126044 and GSE135222). Finally, the characteristics and the response to ICB treatment of LUAD patients between two different IPI subgroups were analyzed.Results: IPI was constructed based on the expression of 5 genes, including A2M, ADRB1, ADRB2, VIPR1 and PTH1R. IPI-high LUAD patients have a better overall survival than IPI-low LUAD patients, consistent with the results in the GEO cohorts. The comprehensive results showed that patients in the IPI-high subgroup were exhibited characters as metabolism-related signaling pathways activation, lower TP53 and TTN mutation rate, more infiltrations of CD8 T cells, dendritic cells and macrophages M1, especially earned more benefit from ICB treatment. In contrast, patients in the IPI-low subgroup were exhibited characters as p53 signaling pathways activation, higher TP53 and TTN mutation rate, more infiltrations of resting memory CD4 T cells, macrophages M2, immune-suppressive response and less benefit from ICB treatment.Conclusion: IPI is a potentially valuable prognostic evaluation method for LUAD, which works well in the benefit predicting of LUAD patients within ICB treatment.
Effects of Pereskia aculeate Miller Petroleum Ether Extract on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats and its Potential Molecular Mechanisms
Authors: Chen Yifei , Liu Kaifei , Qin Yingyuan , Chen Suyi , Guan Guokai , Huang Yao , Chen Yu , Mo Zhixian 
Published: May 2022

Objective: To investigate the therapeutic effect of petroleum ether extract of P. aculeate Miller (PEEP) on rheumatoid arthritis (RA).Methods:In vitro: The Cell Counting Kit-8 (CCK-8) was used to detect cell activity and select the optimal concentration of the extract; the effective site was screened by nitric oxide (NO) colorimetric method and Q-PCR method; the expression of p38, p-p38, p-MK2, and Tristetraprolin (TTP) in RAW 264.7 cells were detected by Western blot. In vivo: The rat model was established by complete Freund’s adjuvant (CFA). The different doses of PEEP on CFA rats were observed with life status, paw swelling, spleen index, X-ray, Hematoxylin eosin (HE) staining; the secretion of Tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and Prostaglandin E2 (PGE2) were detected by Enzyme linked immunosorbent assay (ELISA); the expressions of p38, p-p38, p-MK2, and TTP in the ankle joints of CFA rats were detected by Western blot.Result:In vitro: PEEP, Ethyl Acetate Extract of P. aculeate Miller (EEEP), N-butanol Extract of P. aculeate Miller (BEEP) have no toxic effects on RAW264.7 macrophages. PEEP, EEEP, and BEEP reduce the secretion of NO in RAW264.7 cells induced by lipopolysaccharide (LPS), only PEEP significantly inhibited the mRNA expression levels of inflammatory factors TNF-α and IL-6; PEEP-dependently reduce the secretion of TNF-α and IL-6, decrease the expression of p-p38 and p-MK2, and the level of TTP phosphorylation in LPS-induced RAW264.7 cells. In vivo: PEEP improve the living conditions of CFA rats, reduce foot swelling, spleen index, bone surface erosion and joint space narrowing; reduce the formation of synovial cells, inflammatory cells and pannus in the foot and ankle joints. PEEP reduce the secretion of TNF-α, IL-6, PGE2 in rat serum, downregulate the expression of p-p38 and p-MK2 in the ankle joint, and reduce the phosphorylation of TTP.Conclusion: PEEP improve the living conditions of CFA rats, reduce the degree of foot swelling, protect immune organs, reduce inflammatory cell infiltration, cartilage damage, pannus formation, reduce inflammation and RA damage. The mechanism through regulating the signal pathway of p38 mitogen-activated protein kinase (p38/MAPK), which reduces the release of TNF-α, IL-6, and PGE2 in the serum.
Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice
Authors: Lin Chuangzhen , Yu Bingqing , Chen Lixin , Zhang Zhaohui , Ye Weixiang , Zhong Hui , Bai Wenke , Yang Yuping , Nie Biao 
Published: May 2022

Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. Here, we investigated the role of FXR in the high-dose OCA-induced hepatoxicity in the condition of the NAFLD mouse model.Methods: Wild-type (WT) mice and FXR−/− mice were administered with over-dose OCA (0.40%) and high-dose OCA (0.16%), in a high-fat diet. RNA-seq on liver samples of mice fed with high-dose OCA was performed to dig out the prominent biological events contributing to hepatic fibrosis.Results: Over-dose OCA induced liver injury and shortened survival in WT mice, but not FXR−/− mice. High-dose OCA caused hepatic stellate cell activation and liver fibrosis in the presence of FXR. Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1β and an FXR-mediated inflammatory response.Conclusion: The high-dose OCA induced FXR-dependent hepatic injury via cholesterol accumulation and interleukin -1β pathway in the NAFLD mice.
Heart-Focused Anxiety Affects Behavioral Cardiac Risk Factors and Quality of Life: A Follow-Up Study Using a Psycho-Cardiological Rehabilitation Concept
Authors: Schmitz Christoph , Wedegärtner Sonja Maria , Langheim Eike , Kleinschmidt Judit , Köllner Volker 
Published: May 2022

BackgroundHeart-focused anxiety (HFA) raises the risk for adverse outcomes in patients with heart disease. Despite this great importance, it is rarely assessed in clinical practice. Three dimensions are commonly defined in the context of HFA: heart-related fear, avoidance, and attention. The impact of these aspects on cardiac risk factors is essentially unclear. In this study, we investigated the relationship between HFA and behavioral cardiac risk factors as well as health-related quality of life (HRQoL), which represent important treatment outcomes of inpatient psycho-cardiological rehabilitation.MethodsA prospective observational design was used to examine 238 rehabilitation inpatients with comorbidity of cardiac disease and psychiatric disorder. We assessed HFA using the Cardiac Anxiety Questionnaire (CAQ), HRQoL using the SF-12 Health Survey, exercise capacity using the 6-minute walk test, and smoking behavior, respectively at admission (t0) and discharge (t1). Physical activity was assessed at t0 and in a follow-up survey 6 months after discharge (t2) using the International Physical Activity Questionnaire (IPAQ). Multiple regression models were used to analyze the predictive value of HFA for the outcome variables at t0, t1, and t2, adjusted for socio-demographic factors and depression. Predictive values for changes over time were evaluated by the regressor variable approach.ResultsExercise capacity and physical activity were negatively predicted by baseline heart-related avoidance, both cross-sectionally and prospectively. Avoidance at t1 also negatively predicted long-term changes over time in physical activity at t2. Total HFA and the subcomponent avoidance negatively predicted physical HRQoL both cross-sectionally and prospectively. Mental HRQoL was cross-sectionally predicted by heart-focused attention at t0, and prospectively predicted by total HFA and by avoidance. Regarding changes in the course of rehabilitation, baseline avoidance negatively predicted improvement in physical HRQoL during rehabilitation. Concerning smoking behavior, no associations with HFA were found.ConclusionsHFA is a relevant inhibiting factor for the achievement of therapy goals in psycho-cardiological rehabilitation such as health behavior and HRQoL. Heart-related avoidance in particular, has a negative impact on exercise capacity, physical activity, and self-reported physical health. Its prospective negative predictive value for physical activity and physical health underlines the relevance of HFA for psycho-cardiological interventions.
Female Firefighter Work-Related Injuries in the United States and Canada: An Overview of Survey Responses
Authors: Pawer Samantha , Turcotte Kate , Desapriya Ediriweera , Zheng Alex , Purewal Amanat , Wellar Alyssa , Kunz Kenneth , Garis Len , Thomas Larry S. , Pike Ian 
Published: May 2022

ObjectivesThis study explored how demographic characteristics, life experiences, and firefighting experiences have an impact on work-related injuries among female firefighters, and described events surrounding such work-related injuries.MethodsThis online survey was available from June 2019 to July 2020. Questions related to demographic characteristics, life experiences, firefighting experiences, and work-related injuries. Descriptive analyses characterized variables by the presence or absence of work-related injury, injury severity, job assignment, and country of residence.ResultsThere were 1,160 active female firefighter survey respondents from the US and Canada, 64% of whom reported having at least one work-related injury. US respondents made up 67% of the total but 75% of the injured sample. Injured respondents were older, had been in the fire service longer, and had a greater number of fires and toxic exposures than non-injured respondents. Heavier weight, tobacco use, and alcohol consumption were more common among injured respondents. The two most common contributing factors to work-related injuries were human error and firefighter fatigue. Among respondents who reported an injury-related time loss claim, 69% were wearing protective equipment when injured, and 9% of the injuries directly resulted in new policy implementation.ConclusionsThese findings can help inform resource allocation, and development of new policies and safety protocols, to reduce the number of work-related injuries among female firefighters.
Visual Analysis of Uterine Adhesion Research Based on CiteSpace: Bibliometric Analysis From 2006 to 2021
Authors: Ding Dou-Dou , Zuo Man-Zhen , Zhou Quan , He Ze-Xian 
Published: May 2022

BackgroundIntrauterine adhesionis caused by a variety of reasons, such as damage of the endometrial basal layer, adhesion or occlusion of the uterine cavity or cervix in different degrees. Seriously endangering women's physical and mental health.ObjectiveThe purpose of this paper is to analyze the research development of intrauterine adhesions in recent 15 years, explore the future development direction, and promote the development of this field.MethodsWith intrauterine adhesions and Ashman's syndrome as the theme, the related literatures from January 2006 to July 2021 in the Web of Science were searched, and the visual atlas was analyzed by CiteSpace software.ResultsA total of 644 literatures were included. The key words related to intrauterine adhesion mainly include adhesion, pregnancy, expression, intrauterine adhesions, women, adhesion molecule, diagnosis, activation, hysteroscopy and fertility, etc. Six clusters were obtained by keywords analysis, involving hysteroscopy, placenta, office hysteroscopy, uterus and laparoscopy. Co-occurrence of keywords shows that the research focus in recent years is on endometrial repair and regeneration.ConclusionsThrough the bibliometric analysis of WOS research on intrauterine adhesions in recent 15 years, the comprehensive analysis of countries, institutions, authors and keywords is obtained, which has a clear guiding significance for guiding the future development of intrauterine adhesions.
Effects of substrate temperature and sputtering gas composition on physical properties and photocatalytic activities of WOx thin films deposited via radiofrequency sputtering
Authors: Miyagi Tomoaki , Takahashi Yoshiro , Akimoto Yasuki 
Published: May 2022

Abstract
Tungsten oxide (WOx) is expected to act as a photocatalytic material under visible light. We have deposited WOx thin films using radiofrequency sputtering and evaluated the photocatalytic activities of the films via degradation of methylene blue solution. The optical absorbance, crystallization, and surface morphology of the WOx thin films were also investigated. The absorption edge of the WOx thin films was shifted to the long-wavelength region when the substrate temperature was high and the O2 gas flow rate was low. Crystallization proceeded when the substrate temperature was high and additional WOx diffraction peaks were appearing with low O2 gas flow during growth. Furthermore, the grain size of the WOx thin films was smaller when the O2 gas flow was high. The photocatalytic activity was higher when the substrate temperature and O2 gas flow rate were low.
Orientation angles of liquid crystals via ultrasound vibrations
Authors: Iwase Takahiro , Kuroda Yuma , Onaka Jessica , Emoto Akira , Matsukawa Mami , Koyama Daisuke 
Published: May 2022

Abstract
The orientation angles of liquid crystal (LC) molecules were measured during ultrasound vibrations. Light transmitted through a fabricated LC lens was analyzed via the crossed Nicol condition and a crystal rotation method. The LC orientation angle was estimated with a theoretical model, and its distribution in the lens was determined. There was a strong correlation between the molecular angles and ultrasonic vibrational distributions, indicating that the angle was changed by the acoustic radiation force. The maximum tilt angle was 12° for a 50 V peak-to-peak input.
Microsecond non-melt UV laser annealing for future 3D-stacked CMOS
Authors: Tabata Toshiyuki , Rozé Fabien , Thuries Louis , Halty Sebastien , Raynal Pierre-Edouard , Huet Karim , Mazzamuto Fulvio , Joshi Abhijeet , Basol Bulent M. , Alba Pablo Acosta , Kerdilès Sébastien 
Published: May 2022

AbstractThree-dimensional (3D) CMOS technology encourages the use of UV laser annealing (UV-LA) because the shallow absorption of UV light into materials and the process timescale typically from nanoseconds (ns) to microseconds (μs) strongly limit the vertical heat diffusion. In this work,μs UV-LA solid phase epitaxial regrowth demonstrated an active carrier concentration surpassing 1 × 1021at cm−3in an arsenic ion-implanted silicon-on-insulator substrate. After the subsequent ns UV-LA known for improving CMOS interconnect, only a slight (∼5%) sheet resistance increase was observed. The results open a possibility to integrate UV-LA at different stages of 3D-stacked CMOS.
The location of the mental foramen in relation to the biometrics of the lower dentition and mandibular arch: A cross-sectional study
Authors: Key Yi Wen , Ng Zi-Bin , Al-Namnam Nisreen Mohammed , Nambiar Phrabhakaran , Ngeow Wei Cheong , Chai Wen Lin , Lim Zhi Yin Joan 
Published: May 2022

Purpose: To evaluate the position of the mental foramen among Malaysian Malays and Chinese based on the biometrics of the lower dentition and mandibular arch dimensions.
Materials and methods: The horizontal and vertical position of mental foramen in relation to the midline, roots of teeth, mesiodistal dimension of the anterior and posterior teeth, and the mandibular arch length and width were measured and evaluated in 65 Cone-Beam Computed Tomography scans.
Results: The location of mental foramen was predominantly located either between 1st and 2nd premolar or below 2nd premolar. There were no significant differences for all measurements of the mandible in relation to gender and ethnicities. There was a positive correlation of the mesiodistal diameter of the teeth with the mandibular arch length and width. However, mandibular arch length and width did not affect the location of the mental foramen.
Conclusions: As the size of the teeth increases, the mandibular arch length and the width increase concurrently. However, regardless of the changes in the biometrics of the mandibular dentition and the arch dimensions, the anatomical position of the mental foramen remains the same. The mental foramen was located at the ratio of 0.5 vertically and 0.27 horizontally in the mandible. The inter-foramina distance of 51.36 mm suggests that Malaysian Mongoloids had sufficient space to receive five implants rigidly joined with a bar.
POR ONDE TRANSITAM O TU E O VOCÊ NO NORDESTE?
Authors: Scherre Maria Marta Pereira , Andrade Carolina Queiroz , Catão Rafael de Castro 
Published: May 2022

Neste texto, focalizamos a distribuição dos pronomes pessoais de segunda pessoa no singular na posição de sujeito em pesquisas da região Nordeste do Brasil, com ponderações sobre a projeção de seis subsistemas feita por Scherre et al (2015) e sobre aspectos interacionais em função do tipo de coleta de dados. Tomamos como base o desenho do mapa dos pronomes de segunda pessoa de Scherre et al (2015), as reflexões de Scherre e Andrade (2019), o redesenho do mapa de Scherre, Andrade e Catão (2020) e a apresentação de Scherre (2020) no V Fórum de Estudos Linguísticos do Ceará (FELCE), a partir de diversas análises de pesquisadores brasileiros até 2020. Apresentamos um novo mapa da região Nordeste com percentuais médios de usos de você, cê, ocê, tu sem concordância e tu com concordância e o inserimos no mapa para o Brasil. Conclamamos os pesquisadores para produzirem novas análises de dados de conversas naturais para que possamos organizar o mapa da distribuição dos pronomes de segunda pessoa singular mais próximo à complexa realidade geográfica brasileira, bem como entender com precisão seus diversos matizes discursivos.
Palavras-chave: pronomes pessoais de segunda pessoa singular; português brasileiro; região Nordeste
COMENTÁRIOS SOBRE A ORDEM SUJEITO-VERBO EM ANÚNCIOS DE JORNAIS DO BRASIL OITOCENTISTA
Authors: Araujo Leandro Silveira de 
Published: May 2022

Este trabalho faz uma breve apreciação sobre alguns aspectos da colocação do sujeito na oração da língua portuguesa, empregada no Brasil do século XIX. A análise se desenvolveu a partir de uma seleção de anúncios jornalísticos oitocentistas, compilados na obra “Os Preços Eram Commodos... Anúncios de Jornais Brasileiros Século XIX” (GUEDES, BERLINK, 2000). Os dados observados foram contrapostos a estudos sobre ordem no português (DIAS, 1959; MATTOSO CÂMARA JR., 1975; PONTES, 1987). Sob uma perspectiva especialmente quantitativa, foi possível observar que em anúncios oitocentistas a ordem mais favorecida foi a não-marcada, isto é, com sujeito anteposto ao verbo (60%). Contudo, ainda assim identificamos um alto percentual (40%) de ocorrências da colocação marcada, em que o sujeito é posposto ao verbo. A elevada recorrência desse último dado se dá, em parte, devido ao gênero discursivo, que favorece, por exemplo, o uso de passivas sintéticas. Por fim, observamos que o modelo de posicionamento do sujeito já estava definido no século XIX.
Palavras-chave: Ordem Sintática; Português Brasileiro; Século XIX