bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardizing the measurement and classification of quality of life using the Keratoconus End-Points Assessment Questionnaire (KEPAQ): the ABCDEF keratoconus classification
Authors: Balparda Kepa , Herrera-Chalarca Tatiana , Cano-Bustamante Melissa 
Published: May 2022

Abstract
Background
Measuring quality of life is of importance in keratoconus. So far, the Keratoconus End-Points Assessment Questionnaire (KEPAQ) is the only keratoconus-specific scale to measure emotional well-being along with functional compromise in this population. Nevertheless, there is still a lack of clarity and standardization as to how KEPAQ scores should be computed and reported. There are also no guidelines for interpretation of classification of quality of life when using this instrument. The purpose of this study is to provide a specific framework on how to grade and classify keratoconus by using the KEPAQ and propose an extension of current classification to encompass subjective compromise.

Methods
A group of patients with a confirmed diagnosis of keratoconus underwent application of the KEPAQ. First, a Rasch modeling was performed to evaluate the psychometric characteristics of both sub-scales of the instrument. Then, a linear transformation was performed to turn data into a more relatable scale ranging from 0 to 100. Finally, by using Tukey’s Hinges, scores of the KEPAQ were divided in a 1-to-4 scale, allowing for an easy E&F classification system.

Results
A total of 386 applications of the KEPAQ were included. Analysis provided evidence of the KEPAQ being unidimensional, well-fitted to the Rasch Model, and provided adequate interval-level scores. Linear transformation resulted in a user-friendly final score ranging from 0 to 100, where a higher score translates to having a better quality of life. Two methods of easily computing final score, one by hand and the other one by an Excel file, were constructed. An E&F 1-to-4 classification was proposed, which may work well with the current ABCD classification of keratoconus.

Conclusions
The KEPAQ is a psychometrically robust scale, which confidently measures both emotional-related and functional-related quality of life in patients with keratoconus. It can be easily computed, and the results are interpretable and classified in a manner similar to that used in the ABCD keratoconus classification, by adding letters ‘E’ for emotional and ‘F’ for functional compromise.
A putatively new family of alphaproteobacterial chloromethane degraders from a deciduous forest soil revealed by stable isotope probing and metagenomics
Authors: Kröber Eileen , Kanukollu Saranya , Wende Sonja , Bringel Françoise , Kolb Steffen 
Published: May 2022

Abstract
Background
Chloromethane (CH3Cl) is the most abundant halogenated organic compound in the atmosphere and substantially responsible for the destruction of the stratospheric ozone layer. Since anthropogenic CH3Cl sources have become negligible with the application of the Montreal Protocol (1987), natural sources, such as vegetation and soils, have increased proportionally in the global budget. CH3Cl-degrading methylotrophs occurring in soils might be an important and overlooked sink.

Results and conclusions
The objective of our study was to link the biotic CH3Cl sink with the identity of active microorganisms and their biochemical pathways for CH3Cl degradation in a deciduous forest soil. When tested in laboratory microcosms, biological CH3Cl consumption occurred in leaf litter, senescent leaves, and organic and mineral soil horizons. Highest consumption rates, around 2 mmol CH3Cl g−1 dry weight h−1, were measured in organic soil and senescent leaves, suggesting that top soil layers are active (micro-)biological CH3Cl degradation compartments of forest ecosystems. The DNA of these [13C]-CH3Cl-degrading microbial communities was labelled using stable isotope probing (SIP), and the corresponding taxa and their metabolic pathways studied using high-throughput metagenomics sequencing analysis. [13C]-labelled Metagenome-Assembled Genome closely related to the family Beijerinckiaceae may represent a new methylotroph family of Alphaproteobacteria, which is found in metagenome databases of forest soils samples worldwide. Gene markers of the only known pathway for aerobic CH3Cl degradation, via the methyltransferase system encoded by the CH3Cl utilisation genes (cmu), were undetected in the DNA-SIP metagenome data, suggesting that biological CH3Cl sink in this deciduous forest soil operates by a cmu-independent metabolism.
The impact of annotation on concrete and abstract visual representations in science education: testing the expertise reversal effect
Authors: Zheng Robert , Cordner Holly , Spears Jeffrey 
Published: May 2022

AbstractThis study investigates the effects of annotation on abstract and concrete visual representations in science education. Two studies were conducted: Study 1 investigated the interaction between annotation and visual representations. The results of this study demonstrated that in science learning, annotation with abstract visual representations was superior to annotation with concrete visual representations. Study 2 tested the expertise reversal effect in a three-factor design where the interaction among annotation, visual representation, and prior knowledge was measured. The findings showed that high-prior-knowledge learners performed better in the annotation-abstract visual condition than in the annotation-concrete visual condition where low-prior-knowledge learners showed the opposite outcome—confirming that the expertise reversal effect is at play in how science learners utilize visual information. The study has clarified the roles of prior knowledge, visual representation, and instructional strategy on learner cognitive processing in science education. This knowledge should prove useful for educators as they engage in the design and development of computer-based science learning.
Perceptions of mothers on child well-being, changes in everyday life and social sustainability: lessons learned from a community-based health promotion programme in Anuradhapura District, Sri Lanka
Authors: Guruge Najith Duminda Galmangoda , Arhelger Adam , Abhayasinghe Kalpani 
Published: May 2022

AbstractBackgroundFrom 2012 to 2015, a health promotion intervention (under a project called HADP) aiming to improve children’s well-being was implemented in Horowpathana, Sri Lanka. The donor organization reports positive results regarding children’s well-being and behaviour changes, but mixed results regarding its sustainability. A need for a complementary evaluation was therefore identified.The current study intended to provide a complementary evaluation at four months after the programme closure and to assess the sustainability of the HP intervention from the perspective of mothers who participated in the HADP. Ethical approval for this study was obtained from the ethics review subcommittee of Faculty of Applied Sciences, RUSL.MethodsA descriptive qualitative study was carried out using in-depth, semi-structured interviews with a convenient sample of 15 mothers who previously participated in HADP. Data analysis was done using the content analysis method.ResultsMothers attributed diverse perceptions in line with the theme of “health literacy”. Two sub-themes emerged: transformation for betterment and sustainability. The sub-theme of transformation for betterment consists of three categories: individual-level transformation, family-level transformation and social/community-level transformation. Sub-theme sustainability consists of two categories: (1) drivers/adaptations for continuation and (2) determinants that hinder the continuation.ConclusionsThe mothers’ perspectives were strongly related to the definition of health literacy, which emphasizes people’s ability to use health information to make “well-informed” decisions that incorporate a public health perspective. They also acknowledged the responsibility of social organizations to address health literacy. From a health promotion perspective, the findings of our study indicate that people and organizations can use their health literacy skills to improve the health and well-being of their community and its members. Further research is necessary to explore the factors that affect the sustainability of health promotion interventions in the long run.
Simulation-based procedure training (SBPT) in rarely performed procedures: a blueprint for theory-informed design considerations
Authors: Gent David , Kainth Ranjev 
Published: May 2022

AbstractSimulation-based procedure training is now integrated within health professions education with literature demonstrating increased performance and translational patient-level outcomes. The focus of published work has been centered around description of such procedural training and the creation of realistic part-task models. There has been little attention with regards to design consideration, specifically around how simulation and educational theory should directly inform programme creation. Using a case-based approach in cardiology as an example, we present a blueprint for theory-informed simulation-based procedure training linking learning needs analysis and defining suitable objectives to matched fidelity. We press the importance of understanding how to implement and utilise task competence benchmarking in practice, and the role of feedback and debriefing in cycles of repeated practice. We conclude with evaluation and argue why this should be considered part of the initial design process rather than an after-thought following education delivery.
Scale effects on efficiency and profitability in the Swiss banking sector
Authors: Blatter Marc , Fuster Andreas 
Published: May 2022

AbstractThis paper analyzes efficiency and profitability in the Swiss banking sector over the period 1997–2019. We find strong evidence for scale economies: for most banks in the sample, efficiency and profitability increase with bank size. Using an instrumental variables strategy for a subset of geographically restrained banks, we find that the effect of size on efficiency and profitability is likely causal. Scale economies have been more pronounced since 2010 than in the years prior to the global financial crisis. There is little evidence for scale economies for the largest (systemically important) banks; their relatively lower efficiency and lower profitability appear driven by certain aspects of their business model. Our results further indicate that good capitalization and high efficiency and profitability are compatible.
Psychological effects of, and compliance with, self-isolation among COVID-19 patients in South Batinah Governorate, Oman: a cross-sectional study
Authors: Almayahi Zayid K. , Al Lamki Nasser 
Published: May 2022

Abstract
Background
Covid-19 pandemic has left deep psychological impacts, especially among infected patients. It is extremely important to understand the extent of those effects, while improving the compliance with isolation measures at the same time.

Objectives
To detect prevalence of stress using two psychological scales and examine the stress associated factors, also to identify self-isolation compliance rates among COVID-19 patients.

Methods
Cross-sectional research was conducted from 15 November to 22 December 2020, involving 379 patient participants selected via systematic random sampling. Kessler 10 Psychological Distress (K10) and the impact of event scale-revised (IES-R) tests were used to ascertain the levels of distress.

Results
K10 measure revealed elevated stress amongst 121 (31.9%) of participants, whereas IES_R indicated the level was 37.7%. Using the K10 indicated the multivariate analysis was significant for females (OR = 2.482, 95% CI: 1.532–4.021), patients with financial problems (OR = 2.332, 95% CI: 1.270–4.282) and patients experiencing shortages of essentials (OR = 4.920, 95% CI: 2.524–9.590). The IES-R scale indicated that only female and patients experiencing shortages scored significantly in multivariate analysis, (OR = 1.895, 95% CI: 1.1223–2.935) and (OR = 2.928, 95% CI: 1.1580–5.424), respectively. Those undergoing shorter isolation periods reported lower levels of stress on both K10, p=0.016 and IES-R, p=0.002. Approximately 90% of patients used their own towels during isolation. Moreover, 80.2% slept in separate rooms and 74% used masks in the presence of other family members. Essential supply shortages were reported by 14.2% of respondents.

Conclusions
Self-compliance rates were not optimal, while psychological distress was more prevalent among some groups. Intervention is imperative to minimize stress and improve self-isolation compliance.
Predominant domains and associated demographic and clinical characteristics in multiple sclerosis-related cognitive impairment in mildly disabled patients
Authors: Talebi Mahnaz , Sadigh-Eteghad Saeed , Talebi Malihe , Naseri Amirreza , Zafarani Fatemeh 
Published: May 2022

AbstractBackgroundCognitive impairment (CI) is a common finding in multiple sclerosis (MS); however, there is a limited information about its prevalence in mildly disabled cases. We aimed to determine the most affected domains, and also the relation between the demographic factors and cognitive outcomes in mildly disabled relapsing–remitting MS (RRMS).ResultsNinety-one mildly disabled RRMS patients with expanded disability status scale (EDSS) < 4 and literacy level above 9 years, were recruited. Based on Minimal Assessment of Cognitive Function in MS (MACFIMS) battery, CI was observed in 19.8% of the patients while 40.60% of the patients had at least one failure in cognitive tests. The most common impaired cognitive domain was information processing speed and working memory (27.5%). There was no significant difference between men and women in terms of CI in our sample (p-values > 0.05). Disease duration (p = 0.01), EDSS (p = 0.01), and education (p < 0.01) were significantly different between CI and non-CI patients, while age (p = 0.72), sex (p = 0.50), diagnostic gap (p = 0.89), and frequency of relapses (p = 0.22), did not differ considerably.ConclusionsRRMS patients experience some degrees of CI that may present even before the onset of remarkable physical disability; nevertheless, a higher EDSS score and longer disease duration increases the risk of CI. These findings suggest routine cognitive assessment of MS patients.
Peripheral inflammation and neurodegeneration; a potential for therapeutic intervention in Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS)
Authors: Hanna Lourdes , Poluyi Edward , Ikwuegbuenyi Chibuikem , Morgan Eghosa , Imaguezegie Grace 
Published: May 2022

Abstract
Background
Degeneration of the central nervous system (CNS), also known as neurodegeneration, describes an age-associated progressive loss of the structure and function of neuronal materials, leading to functional and mental impairments.

Main body
Neuroinflammation contributes to the continuous worsening of neurodegenerative states which are characterised by functional and mental impairments due to the progressive loss of the structure and function of neuronal materials. Some of the most common neurodegenerative diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Whilst neuroinflammation is a key contributor to the progression of such disease states, it is not the single cause as there are multiple factors which contribute. Theoretically, non-steroidal anti-inflammatory drugs (NSAIDs) have potential to target neuroinflammation to reduce the severity of disease states. Whilst some animal models investigating the effects of NSAIDs on the risk of neurodegenerative diseases have shown a beneficial effect, this is not always the case and a large number of clinical trials have not shown the same finding.

Conclusion
Further investigation using more advanced research methods is required to better understand neuroinflammatory pathways and understand if there is still a potential window for NSAID efficacy.
A comparative study between ultrasound-guided serratus anterior plane block and conventional IV analgesics for post-operative pain management in modified radical mastectomy
Authors: Abdel Rahman Mennat-Alla Ahmed Fouad , Salama Hala Gomaa , Razik Rehab Abdel Fattah Abdel , Galal Reham Fathy , Farag Hanan M. 
Published: May 2022

Abstract
Background
Surgery is the first line of treatment for early, localized, or operable breast cancer and it is associated with severe post-operative pain. Although opioids have been the mainstay for managing post-operative pain, they have undesirable side effects. A variety of methods, including thoracic epidural, paravertebral, and intercostal blocks have been used to manage breast surgery pain; however, each of these blocks has some drawbacks. Serratus anterior plane block is a relatively novel technique that can block the lateral cutaneous branches of the intercostal nerves as well as the long thoracic nerve. This study compares between the effect of serratus anterior plane block and conventional IV analgesia on post-operative pain after modified radical mastectomy.

Results
Post-operative pain scores were significantly lower in the SAPB group in the first 8 h compared to the control group (P < 0.05), the time to the first rescue analgesic was significantly longer in the SAPB group with a mean 354 min compared to the control group; the mean is 17.8 min, the total dose of rescue analgesic was significantly lower in the SAPB group with a mean 50 mg in the first 24 h compared to a mean of 212.5 mg in the control group. The patient’s satisfaction scores were higher, the incidence of post-operative nausea and vomiting was significantly lower among the SAPB group compared to the control group. No other complications were recorded in either group.

Conclusions
The serratus anterior plane block can be used as one of the modalities in managing the pain of patients undergoing MRM surgery. This procedure was effective in reducing the need for post-operative opioids usage, better patient satisfaction with fewer side effects as post-operative nausea and vomiting. It is simple and easy-to-learn technique.
Factors influencing the acceptance and patronage of E-commerce logistics operations in Nigeria
Authors: Adeniran Adetayo Olaniyi , Akinsehinwa Feyisola Olajire , Olorunfemi Samuel Oluwaseyi 
Published: May 2022

Abstract
Background
In the global world that is technologically driven, efficiency and productivity of businesses that have decided to embrace technology are achieved by e-commerce logistics (ECL). E-commerce logistics has received momentous attention in the developed countries but less attention in the developing countries. There have been some elements of uncertainty regarding the relevance of e-commerce logistics especially in the developing countries. To fill this gap, this study explored the factor influencing the acceptance and patronage of e-commerce logistics in Nigeria.

Methods
The following e-commerce and logistics businesses: Jumia, Konga, Kobo360, Breath2Wealth, Okrikah, DeliveryBros, Cartehub, STYLISTAA, and DayDone Limited, were explored in this study. The organizations were chosen because they were known for both e-commerce and logistics business. Qualitative research method and case study research design were employed for data collection through a purposive sampling technique. Primary data were targeted at two representatives from each organization.

Conclusions
The study found that external factors, political situation, government initiatives, economic situation, geographical situation, technology infrastructure, sociocultural situation, and public wakefulness have significant influence on the acceptance and patronage of e-commerce logistics in Nigeria. The study also found that many e-commerce companies also venture into distribution, thereby providing some level of logistics such as warehousing, packaging, and transportation, but they were not well informed that their operation is beyond e-commerce. It is therefore recommended that such organization should include logistics to their operation. E-commerce logistics organization should clearly state their terms and condition regarding the law of carriage which should be in accordance to the Nigeria law of Carriage.
GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts
Authors: Chirumamilla Pavani , Dharavath Sunitha Bai , Taduri Shasthree 
Published: May 2022

Abstract
Background
Solanum khasianum is an important medicinal herb of the Solanaceae family. The present study was focused to determine the bioactive compounds in S. khasianum leaf and root extract by GC–MS analysis and their antibacterial activity by agar well diffusion method.

Results
Sixteen bioactive compounds were detected in leaf extract and thirty-two compounds in root methanolic extract by GC–MS. The major potent compounds identified in leaf and root extracts were heptadecane 9-hexyl (43.65%) and stigmasterol (23.18%). The root extract showed increased antibacterial activity than leaf extract.

Conclusion
These extracts possessed significant antibacterial activity against the tested bacterial isolates in dose-dependent manner. This study provides the phytoconstituents, antibacterial property and scientific evidence for the traditional claim and use of S. khasianum.
Effects of Vernonia amygdalina methanol leaf extract and fractions on Ascaridia galli in experimentally infected birds with regard to its pathological effect
Authors: Gasaliyu Khadijat Abidemi , Ajanusi Oseka Joseph , Suleiman Mohammed Musa , Dahiru Sani , Yusuf Kuburat Hadiza , Kyari Stephen , Ogwiji Matthew , Orakpoghenor Ochuko 
Published: May 2022

Abstract
Background
Helminthiasis, usually a chronic problem in poultry, is the major cause of economic losses in the poultry industry. This study was undertaken with the aim of evaluating the in vitro and in vivo anthelmintic effects of Vernonia amygdalina methanol leaf extract and fractions on Ascaridia galli in experimentally infected birds. Standard protocols for extraction, phytochemical screening, isolation and infection of parasite and histological examination were followed.

Result
At 50 mg/ml albendazole (ALB) caused the highest inhibition of embryonation (97.3%) followed by crude methanol extract (CME) (94.5%), ethyl acetate fraction (EAF) (81.3%) and butanol fraction (BF) (80.3%). The lowest faecal egg counts (FEC) and highest FEC at 21 days post-treatment were observed in the group treated with albendazole (99.2%) and CME at 800 mg/kg (96.9%). Deparasitization at 200 mg/kg caused by ALB was (93.8%), while at 200, 400 and 800 mg/kg, CME was (77.5%, 87.5% and 91.86%), BF was (75.51%, 79.61% and 85.73%) and EAF was (73.48%, 75.5% and 81.63%), respectively. At post-mortem, broiler chickens infected with A. galli and treated with CME, BF and EAF at 200 mg/kg had desquamation of the villi while at 400 and 800 mg/kg treatments, the intestines were intact.

Conclusion
The extract and fractions of V. amygdalina were found to possess anthelmintic activity against A. galli due to the inhibition of embryonation of eggs and the reduction in faecal egg count; further research is required to fully ascertain their mechanism of action of the extract.