bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Food‐Effect Study to Evaluate the Oral Bioavailability of Desidustat
Authors: Patel Hardik , Momin Taufik , Kansagra Kevinkumar , Patel Harilal , Shah Chintan , Barot Ajaykumar , Bhavsar Jay , Zala Kuldipsinh , Parmar Deven 
Published: December 2022

AbstractThis randomized, single‐treatment, 2‐sequence study evaluated the food effect on oral bioavailability of desidustat. Healthy adult male and female subjects were enrolled and randomly assigned to receive desidustat 50 mg orally in a fasting state in one period and a fed state in the other period. A standardized high‐fat, high‐calorie breakfast was served to assess the food effect. The pharmacokinetic results showed that the time to maximum blood concentration of desidustat was delayed significantly (P < .0001) in the fed state compared to the fasting state. The ingestion of food decreased the maximum blood concentration (Cmax) compared to the fasting state (mean Cmax, 3248 ng/mL in the fed state vs 5496 ng/mL in the fasting state). The geometric mean ratio of fed/fasting for log‐normal (ln) Cmax was 57. The exposure decreased in the fed state compared to the fasting state (mean area under the concentration‐time curve [AUC] over the dosing interval, 25 559 ng • h/mL in the fed state versus 33 705 ng • h/mL in the fasting state; mean AUC from time 0 to infinity [AUC0‐∞], 25,910 ng • h/mL in the fed state vs 34 233 ng • h/mL in the fasting state). The geometric mean ratio of fed/fasting for lnAUC from time 0 to the last quantifiable concentration and ln AUC0‐∞ was 77 and 76, respectively. The 90%CI of fed/fasting ratio of the geometric mean of lnCmax, AUC over the dosing interval, and AUC0‐∞ of desidustat 50 mg did not fall within 80%–125% margin. Therefore, the absence of food effect could not be established. It can be inferred that food has a significant effect on the oral absorption of desidustat. Therefore, food must not be consumed 1 hour before and 2 hours after the oral administration of desidustat.
Significance of visual scene‐based learning in the hippocampal systems across mammalian species
Authors: Lee Su‐Min , Shin Jhoseph , Lee Inah 
Published: December 2022

AbstractThe hippocampus and its associated cortical regions in the medial temporal lobe play essential roles when animals form a cognitive map and use it to achieve their goals. As the nature of map‐making involves sampling different local views of the environment and putting them together in a spatially cohesive way, visual scenes are essential ingredients in the formative process of cognitive maps. Visual scenes also serve as important cues during information retrieval from the cognitive map. Research in humans has shown that there are regions in the brain that selectively process scenes and that the hippocampus is involved in scene‐based memory tasks. The neurophysiological correlates of scene‐based information processing in the hippocampus have been reported as “spatial view cells” in nonhuman primates. Like primates, it is widely accepted that rodents also use visual scenes in their background for spatial navigation and other kinds of problems. However, in rodents, it is not until recently that researchers examined the neural correlates of the hippocampus from the perspective of visual scene‐based information processing. With the advent of virtual reality (VR) systems, it has been demonstrated that place cells in the hippocampus exhibit remarkably similar firing correlates in the VR environment compared with that of the real‐world environment. Despite some limitations, the new trend of studying hippocampal functions in a visually controlled environment has the potential to allow investigation of the input–output relationships of network functions and experimental testing of traditional computational predictions more rigorously by providing well‐defined visual stimuli. As scenes are essential for navigation and episodic memory in humans, further investigation of the rodents' hippocampal systems in scene‐based tasks will provide a critical functional link across different mammalian species.
SOURCE beyond first‐line: A survival prediction model for patients with metastatic esophagogastric adenocarcinoma after failure of first‐line palliative systemic therapy
Authors: Kuijper Steven C. , Pape Marieke , Haj Mohammad Nadia , van Voorthuizen Theo , Verhoeven Rob H. A. , van Laarhoven Hanneke W. M. 
Published: December 2022

AbstractPrior models have been developed to predict survival for patients with esophagogastric cancer undergoing curative treatment or first‐line chemotherapy (SOURCE models). Comprehensive clinical prediction models for patients with esophagogastric cancer who will receive second‐line chemotherapy or best supportive care are currently lacking. The aim of our study was to develop and internally validate a new clinical prediction model, called SOURCE beyond first‐line, for survival of patients with metastatic esophagogastric adenocarcinoma after failure of first‐line palliative systemic therapy. Patients with unresectable or metastatic esophageal or gastric adenocarcinoma (2015‐2017) who received first‐line systemic therapy (N = 1067) were selected from the Netherlands Cancer Registry. Patient, tumor and treatment characteristics at primary diagnosis and at progression of disease were used to develop the model. A Cox proportional hazards regression model was developed through forward and backward selection using Akaike's Information Criterion. The model was internally validated through 10‐fold cross‐validations to assess performance. Model discrimination (C‐index) and calibration (slope and intercept) were used to evaluate performance of the complete and cross‐validated models. The final model consisted of 11 patient tumor and treatment characteristics. The C‐index was 0.75 (0.73‐0.78), calibration slope 1.01 (1.00‐1.01) and calibration intercept 0.01 (0.01‐0.02). Internal cross‐validation of the model showed that the model performed adequately on unseen data: C‐index was 0.79 (0.77‐0.82), calibration slope 0.93 (0.85‐1.01) and calibration intercept 0.02 (−0.01 to 0.06). The SOURCE beyond first‐line model predicted survival with fair discriminatory ability and good calibration.
The effect of strontium content on physicochemical and osteogenic property of Sr/Ag‐containing TiO2 microporous coatings
Authors: Wang Yi‐Rui , Yang Nuo‐Ya , Sun Hong , Dong Wei , Deng Jiu‐Peng , Zheng Tian‐Xia , Qi Meng‐Chun 
Published: December 2022

AbstractStrontium (Sr) is the most common element introduced into TiO2 coatings to strengthen the osteogenic property of titanium implants. However, the optimal Sr content and its effect on osteogenic and physicochemical properties of the coatings need to be clarified. In the current study, TiO2 microporous coatings with different contents of Sr (9.64–21.25 wt %) and silver (Ag) (0.38–0.75 wt %) were prepared via micro‐arc oxidation technique. Sr contents did not change physicochemical properties of the coatings, including surface microstructure, micropore size and distribution, phase composition, roughness and hydrophilicity. Meanwhile, higher Sr contents (18.23–21.25 wt %) improved cytocompatibility, proliferation and alkaline phosphatase (ALP) activity of preosteoblasts, even the coatings underwent 30 days' PBS immersion. Furthermore, higher Sr contents facilitated preosteoblast growth and spreading, which are essential for their proliferation and osteogenic differentiation. Therefore, it is promising to incorporate higher Sr content (18.23–21.25 wt %) within TiO2 microporous coatings to improve their osteogenic capability.
HSPA6, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer
Authors: Zhang Lihua , Zhuo Hui‐qin , Hong Zhi‐jun , Hou Jing‐jing , Cheng Jia , Cai Jianchun 
Published: December 2022

AbstractObjectiveThis study aimed to explore the clinical relevance of heat shock protein family A member 6 (HSPA6) in gastric cancer (GC) and its effect on GC cell proliferation.MethodsHSPA6 mRNA and protein levels were analyzed by bioinformatics, RT‐qPCR, western blot and immunohistochemistry. HSPA6 was correlated with clinicopathological variables by the Chi‐square test. Kaplan–Meier survival analysis and the univariate and multivariate Cox models were used to assess the prognostic value of HSPA6. Nomogram was used to predict overall survival in patients with GC. Knockdown or over‐expression of HSPA6 in GC cell lines was constructed by lentiviral transduction. EdU and CCK‐8 assay were used to detect cell proliferation. In vivo mouse tumor models were performed to evaluate the effects of HSPA6 on GC growth.ResultsHSPA6 were significantly upregulated in the GC tissues compared to the normal stomach epithelium and were associated with Ming classification (p < 0.001) and tumor size (p = 0.002). Patients with high expression of HSPA6 showed worse survival compared to the low expression group. HSPA6 was identified to be an independent prognostic biomarker for GC. HSPA6 was functionally annotated with the cell cycle, G2M checkpoint and Hippo pathway. Knockdown of HSPA6 suppressed XGC‐1 cell proliferation both in vitro and in vivo. Overexpression of HSPA6 in AGS cells increased proliferation rates, increased the levels of cyclinB1 and YAP and decreased that of phosphorylated YAP. HSPA6 knockdown in the NUGC2 cells had the opposite effect.ConclusionsHSPA6 promotes GC proliferation by the Hippo pathway, as a novel prognostic biomarker and potential therapeutic target.
Stress exacerbates pancreatic cancer both directly and indirectly by creating an immunosuppressive environment
Authors: Ikeda Takahiro , Adachi Tomohiko , Tanaka Takayuki , Miyamoto Daisuke , Imamura Hajime , Matsushima Hajime , Yamamoto Kazuo , Hidaka Masaaki , Kanetaka Kengo , Eguchi Susumu 
Published: December 2022

AbstractBackground/PurposeSympathetic nerve stimulation by stress exacerbates various solid tumors, including pancreatic cancer (PCa). The relationship between cancer and immunity has been suggested; however, there is limited information about the effects of nerve stimulation on immunity and cancer. We aimed to investigate the involvement of sympathetic nerve stimulation in immune cells and its effects on PCa using a restraint stress mouse model.MethodsIn the in vitro experiment, the mouse‐derived PCa cell line (LTPA) was cultured in a noradrenalin‐supplemented medium. In the in vivo experiment, mice were divided into non‐stress and stress groups.ResultsLTPA proliferated significantly more when cultured in a noradrenalin‐supplemented medium than in a normal medium. Flow cytometry analysis of blood immune cells revealed a significant decrease in B cells, T cells, and macrophages and a significant increase in myeloid‐derived suppressor cells (MDSCs) in the stress group. Furthermore, a significant increase in blood noradrenaline levels was observed in the stress group (p < .01). In the PCa mice model, immune cells in the blood showed a similar trend, and the stress group had a poor prognosis. Furthermore, immunostaining at the tumor site showed that there was a lower number of B and T cells in the stress group. In addition, MDSCs were present at the tumor margins.ConclusionThese results suggest that sympathetic nerve stimulation is not only directly involved in PCa growth but also exacerbates PCa by creating an immunosuppressive environment in the blood and tumor tissue.
Career counseling as relapse prevention: A theoretical look at social cognitive career theory in supporting recovery from substance use
Authors: Maynes Teresa D. , Nishikawara Ria K. 
Published: December 2022

AbstractThere is emerging evidence on the relationship between career outcomes and success in substance use recovery, in that individuals who are gainfully employed are more likely to have positive recovery outcomes, including reduced risk of relapse. Although career interventions for those in recovery exist, no intervention has focused on the intersection of career development and relapse prevention. This article explores a theoretical integration of relapse prevention and social cognitive career theory to increase the self‐efficacy, outcome expectancies, and coping of individuals in recovery, as well as implications and practical applications of this orientation for both career and substance use counselors.
Cross‐cultural adaptation of the Hebrew Nasal Obstruction Symptom Evaluation (NOSE) scale
Authors: Daoud Amani , Eisenbach Netanel , Ronen Ohad , Dror Amiel , Ohayon Tali Jane , Hajouj Majd , Sela Eyal , Marshak Tal 
Published: December 2022

AbstractObjectiveNasal obstruction is a common complaint. The Nasal Obstruction Symptom Evaluation scale (NOSE) is a reliable validated tool used to assess the quality of life of patients with nasal obstruction. The purpose of this study is to validate the Hebrew version of the NOSE scale (He‐NOSE).MethodsA prospective instrument validation was conducted. The NOSE scale was translated primarily from English to Hebrew and then back from Hebrew to English according to the accepted guidelines of the cross‐cultural adaptation process. The study group included surgery candidates suffering from nasal obstruction due to a deviated nasal septum and/or inferior turbinate hypertrophy. The study group completed the validated He‐NOSE questionnaire twice prior to the surgery and once again, a month post‐surgery. A control group of individuals with no history of nasal complaints or surgeries was asked to complete the questionnaire once. Reliability, internal consistency, validity, and responsiveness to change of the He‐NOSE were evaluated.ResultsFifty‐three patients and 100 controls were included in this study. The scale showed excellent ability to discriminate between the study and the control group, exhibiting significantly lower scores in the control group (73.8 and 7 average scores respectively, p < .001). Good internal consistency (Cronbach's alpha .71 and .76) and test–retest reliability (Spearman rank correlation r = .752, p < .0001) were measured. Moreover, the scale revealed remarkable responsiveness to change (p < .00001).ConclusionThe translated and adapted He‐NOSE scale can be a useful tool to be applied in both clinical and research fields when assessing nasal obstruction.Level of evidenceN/A.
Registration of ‘S11‐16653C’ soybean: A high‐yielding conventional cultivar with broad resistance to diseases and nematodes
Authors: Shannon G. , Chen P. , Lee Y.‐C. , Canella Vieira C. , Ali M. L. , Lee D. , Scaboo A. , Crisel M. , Smothers S. , Clubb M. , Nguyen H. T. , Li Z. , Mitchum M. G. , Bond J. , Meinhardt C. , Usovsky M. , Robbins R. T. 
Published: December 2022

AbstractThe soybean [Glycine max (L.) Merr] line S11‐16653C (Reg. no. CV‐554, PI 700000) was developed and released as a cultivar by the University of Missouri, Fisher Delta Research, Extension, and Education Center (MU‐FDREEC). S11‐16653C is an early maturity group V (relative maturity 5.3), high‐yielding conventional (non‐genetically modified) cultivar with determinate growth habit. It is a chloride excluder and has a broad disease resistance package, including soybean cyst nematode (Heterodera glycines Ichinohe) races 1 (HG type 2.5.7), 2 (HG type 1.2.5.7), 3 (HG type 5.7), 5 (HG type 2.5.7), southern root‐knot nematode [Meloidogyne incognita (Kofold & White) Chitwood], peanut root‐knot nematode [Meloidogyne arenaria (Neal) Chitwood], reniform nematode (Rotylenchulus reniformis Linford & Oliveira), stem canker (Diaporthe aspalathi Jansen, Castlebury & Crous), Phytophthora root rot (caused by Phytophthora sojae M.J.Kaufmann & J.W.Gerdemann), and sudden death syndrome (Fusarium virguliforme O'Donell & T. Aoki). S11‐16653C was tested in 78 locations across nine states (Alabama, Arkansas, Kansas, Louisiana, Missouri, Mississippi, North Carolina, Tennessee, and Virginia) from 2012 to 2016. It was entered in internal yield tests at the MU‐FDREEC (2012–2014), USDA Uniform Soybean Tests (2014–2016), and soybean state variety tests (2015). It showed consistent high‐yielding performance and broad adaptability throughout the trials and locations. Overall, S11‐16653C is a high‐yielding conventional soybean cultivar that has potential for commercial production and serves as an exceptional germplasm for soybean breeding.
Hydrogen gas permeation in peroxide‐crosslinked ethylene propylene diene monomer polymer composites with carbon black and silica fillers
Authors: Jung Jae K. , Baek Un B. , Lee Sang H. , Choi Myung C. , Bae Jong W. 
Published: December 2022

AbstractThis study investigated the effect of two types of fillers, carbon black (CB) and silica, on the H2 permeation of peroxide‐crosslinked ethylene propylene diene monomer (EPDM) polymers at different pressures (1.2–9.0 MPa). The H2 uptake was linearly correlated with the exposure pressure in all specimens. The H2 solubility in the filled EPDM composites also increased linearly with an increase in the filler content. The H2 solubility was determined by the absorption of polymer networks and adsorption at the filler surface in the CB‐filled EPDM. Meanwhile, the H2 solubility in neat and silica‐filled EPDM was dominated by the polymer network absorption. In the filled EPDM, H2 diffusivity decreased because the filler increased the tortuosity of the polymer. The effects of filler on H2 permeation were largest in the high‐abrasion and semi‐reinforcing furnaces, while the effects were lowest in the silica filler. This trend was associated with the surface area and interface of the fillers. The correlations of the average diffusivity (or permeability) with the filler content and crosslink density of the composites were observed and discussed. From the resulting relationships, we can predict the H2 permeation properties of the compounded EPDM candidates, when used as seal materials, under high‐pressure environment in H2‐refueling stations.
Sex differences in depression for childhood cancer survivors
Authors: Zhang Yafeng , Li Zhe , Wang Chunli , Zhang Linqi , Guo Shufang , Lin Jia , Zhou Chongchen , Zhang Zhong , Huo Shan , Fan Lihua , Ni Xin 
Published: December 2022

AbstractObjectiveThis study examines the differential association between sex and depression, and the possible mediating pathways.MethodsWe analysed survey data from 296 (age 7–17.1 years) cancer survivors from three centres affiliated with Beijing Children's Hospital. Linear regression analysis was used to assess the association between sex and depression. Quantile regression analysis was used to estimate the regression coefficients (β) and 95% confidence intervals for sex in depression at different quantiles. Mediation analysis with multiple mediators was used to explore the effects of sex on depression.ResultsUsing linear regression, we found that the age ranged from 8.7 to 10.4 years and the regression coefficient of sex on depression was significant (β = −2.75, p = 0.03). Quantile regression results showed a significant negative association between sex and depression in the 0.30–0.75 quantiles. Mediation analysis revealed that boys were 1.545 times more depressed than girls, with family resilience, self‐perceived burden, and behavioural problems explaining approximately 16.79%, 21.57%, and 43.94% of the sex difference, respectively. The combined effect of family functioning, resilience, social support, self‐perceived burden, and behavioural problems might explain the 89.17% sex difference.ConclusionClinicians should consider sex effects when assessing depression in childhood cancer survivors and target sex‐specific interventions for further treatment.
Asymptotic tracking with novel integral robust schemes for mismatched uncertain nonlinear systems
Authors: Yang Guichao 
Published: December 2022

AbstractMotivated by the desire to extend the well‐known robust integral of the sign of the error (RISE) feedback control to handle both matched and mismatched disturbances simultaneously, two novel continuous integral robust control algorithms with asymptotic tracking performance will be constructed for a class of high‐order uncertain nonlinear systems. By skillfully introducing a set of filtered error variables and asymptotic filters as well as an auxiliary system, they will be integrated via an improved backstepping framework. Significantly, the virtual control law integrated at each procedure will pass through a novel asymptotic filter and then the filtered signal will be adopted in the subsequent backstepping iteration. Notably, one of the control algorithms is constructed via the integral of the sign of the filtered error variable introduced at each step, which makes it incalculable due to the unmeasurable states. In order to implement this controller, two measures for calculating the sign function in terms of the filtered error variable will be expounded. More importantly, the stability of the closed‐loop system under each controller will be strictly proved and meanwhile application examples will be performed to demonstrate the theoretical results.
Effect of Iron Loading on Controlling Fe/N−C Electrocatalyst Structure for Oxygen Reduction Reaction
Authors: Nugroho Agung , Wahyudhi Agus , Oktaviano Haryo Satriya , Yudianti Rike , Hardiansyah Andri , Destyorini Fredina , Irmawati Yuyun 
Published: December 2022

AbstractFe/N−C electrocatalysts were synthesized using iron chloride, ammonium chloride, glycine, and acetylene black by pyrolysis at 900 °C under nitrogen atmosphere. Acid leaching process successfully removed non‐bonded Fe which confirmed by X‐ray Diffraction (XRD) analysis. Deconvolution of Raman spectra showed that Fe1−NC had a high ID/IG value of 1.37 due to the presence of defect sites and disordered carbon structure. The calculation result showed that higher Fe loading leads to the carbon structure rearrangement into graphitic structure, thus reducing the ID/IG to 1.06. The cyclic voltammetry (CV) test of Fe1−NC shows the best catalytic performance for oxygen reduction reaction (ORR) compared to higher Fe‐loading samples. Rearrangement in the carbon structure into the more graphitic led to active sites decrease, thus resulted in a decrease of IORR from 4.6 to 1.7 μA for Fe1−NC and Fe20−NC. This study indicates that optimum iron loading could be an essential factor in improving catalyst performance.
Developing an Ultrasensitive Colorimetric Assay for Low‐abundance Iron‐tetraamido Macrocyclic Ligand (Fe−TAML) Catalyst
Authors: Zhang Zhuang , Wang Ying , Gan Hui Ting , Yang Kun‐Lin 
Published: December 2022

AbstractFe−TAML is a well‐known green catalyst for bleaching and wastewater treatments. Quantitative analysis of Fe−TAML is important to understand its activity and lifetime in these applications. However, because of its sub‐parts‐per‐million dosage and the presence of interfering substances, it is very challenging to detect Fe−TAML specifically and quantitatively at this level. To overcome these issues, we develop a quantitative assay for Fe−TAML, which is based on its catalytic reaction with a blue dye (Reactive Blue 19) and H2O2. This assay is highly specific, and shows no interference for iron species. Moreover, the colorimetric assay can be carried out for fast screening of Fe−TAML with a limit of detection (LOD) of 0.39±0.08 μg L−1. Finally, this assay was successfully applied to understand the stability of Fe−TAML under various conditions, and monitoring the activity of Fe−TAML during wastewater treatments.