bluuebunny/crossref_metadata_2025_split huggingface dataset:
El séptimo sello (1957), entre pestes y sindemias
Authors: Moreta Velayos Francisco Ignacio , Moreta Montero Carolina , Sánchez de la Mano Flori , Ramírez Oribe Carmen , Sica Sica Manuela Alina , Montero Sánchez Nieves 
Published: February 2022

Tal que, a otros muchos, sin duda, con el inicio de los confinamientos decretados para intentar contener la actual pandemia, nos vino a la cabeza El séptimo sello (1957) de Bergman, relacionando los acontecimientos del tiempo en que se desarrolla la película con los que vivíamos y vivimos actualmente: la epidemia de Peste Negra que asolaba Suecia en el siglo XIV de un lado y la pandemia por Covid-19 de otro, sindemias ambas como algunos prefieren llamarlas.
Tomando como disculpa la obra de Ingmar Bergman nuestra pretensión es hacer algunas comparaciones entre la peste medieval y la pandemia actual aportando algunas reflexiones y opiniones personales surgidas muchas de ellas de nuestra propia experiencia durante estos largos meses.
Endoscopic Papillary Large Balloon Dilation Reduces Further Recurrence in Patients With Recurrent Common Bile Duct Stones: A Randomized Controlled Trial
Authors: Wang Xu , Wang Xiangping , Sun Hao , Ren Gui , Wang Biaoluo , Liang Shuhui , Zhang Linhui , Kang Xiaoyu , Tao Qin , Guo Xuegang , Luo Hui , Pan Yanglin 
Published: February 2022

INTRODUCTION:
Up to 60% of patients with common bile duct stone (CBDS) recurrence suffer from further recurrence after endoscopic retrograde cholangiopancreatography (ERCP). There are no effective methods to prevent recurrence in most patients. In this study, we aimed to assess the short-term and long-term efficacies of endoscopic papillary large balloon dilation (EPLBD) for the management of recurrent CBDS in a randomized controlled trial.

METHODS:
Consecutive patients with recurrent CBDS were eligible and randomly assigned in a 1:1 ratio to the EPLBD group or the control group. The primary outcome was the CBDS recurrence rate within 2 years after ERCP. The analysis followed the intention-to-treat principle.

RESULTS:
From 2014 to 2021, 180 patients with recurrent CBDS were included, with 90 in each group. All patients underwent complete CBDS clearance by 1 or several sessions of ERCP. The rate of complete clearance in 1 session was significantly higher with EPLBD treatment (95.6% vs 85.6%, P = 0.017). During the follow-up, the CBDS recurrence rate within 2 years was significantly lower in the EPLBD group than in the control group (21.1% [19/90] vs 36.7% [33/90], relative risk 0.58, 95% confidence interval 0.36–0.93, P = 0.021). At a median follow-up of approximately 56 months, CBDS recurrence was found in 34.4% of the patients (31/90) in the EPLBD group and 51.1% (46/90) in the control group (hazard ratio 0.57, 95% confidence interval 0.36–0.89, P = 0.012). Multiple recurrences (≥2) were also decreased in the EPLBD group (4.4% vs 18.9%, P = 0.020).

DISCUSSION:
During the long-term follow-up, nearly half of the patients with recurrent CBDS experienced stone recurrence after traditional ERCP. Our study was the first to show that EPLBD effectively reduced the recurrence of CBDS.
Wood-water interactions of thermally modified, acetylated and melamine formaldehyde resin impregnated beech wood
Authors: Čermák Petr , Baar Jan , Dömény Jakub , Výbohová Eva , Rousek Radim , Pařil Petr , Oberle Anna , Čabalová Iveta , Hess Dominik , Vodák Michal , Brabec Martin 
Published: February 2022

Abstract
The wood-water interactions of modified beech wood (Fagus sylvatica L.) were studied. Specimens were thermally modified at 180 (TM1), 200 (TM2) and 220 °C (TM3), acetylated (Acet), and melamine formaldehyde (MF) resin (Mel) modified. Afterwards, the water vapour characteristics, i.e. water vapour sorption isotherms, equilibrium moisture content (EMC), dimensional stability of specimens conditioned at 30, 65 and 90% RH and liquid water characteristics, i.e. water absorption, maximum moisture content (MC), leachability and swelling kinetics, were determined and the results compared with reference (Ref) specimens. From the results, it is evident that the scale of wood-water interactions was highly dependent on the thermal modification temperature and type of chemical modification. The water vapour isotherms of thermally modified wood decreased, whereas more severe treatment exhibited more distinct reduction. The EMC values of the Mel and TM1 specimens decreased only at high RH, whereas the most significant decrease, within the whole range of observation, was found in the Acet group. The maximum MC reduction was achieved by acetylation. As a consequence of swelling reduction, dimensional stability expressed as anti-swelling efficiency (ASE) was considerably improved. A relatively high initial linear-phase swelling rate was found for the Ref specimens, whereas modified wood exhibited comparatively slow and gradual swelling.
Heat-flow parameters affecting microstructure and mechanical properties of Al–Cu and Al–Ni alloys in directional solidification: an experimental comparative study
Authors: Júnior Paulo Felipe , de Olivé Ferreira Leonardo , Garção Wysllan Jefferson Lima , de Paula Almeida Rangel , Melo Camilla Mota , Ferreira Alexandre Furtado 
Published: February 2022

Abstract
A comparative analysis was carried out of the alloys examined, using the results found for thermal variables, macrostructure, dendrite arm spacing, modulus of elasticity and microhardness. Comparing all the results for variables, a predominance was found of higher values for the Al-5.0 wt.% Cu alloy in relation to those for the Al-5.0 wt.% Ni alloy. Although structural transition has occurred in both alloys, the columnar–equiaxed transition position in castings was not altered during the solidification experiments. Addition of Ni solute into pure aluminum favors a significant decrease in tertiary dendrite spacing, while Cu addition leads to a coarser microstructure. Primary dendrite arm spacing, also, was measured along the castings of both alloys. Theoretical approaches such as the well-known Hunt–Lu, Bouchard–Kirkaldy, and Kurz–Fisher models were used to determine quantitatively this particular microstructural parameter. Good agreement was observed between experimental data and predictions by Hunt–Lu and Bouchard–Kirkaldy models, which assume solidification under a transient heat-flow condition. Finally, empirical equations relating tertiary dendritic arm spacing and mechanical properties to the scale of the dendritic microstructure have been proposed. While no relationship was observed between modulus of elasticity and tertiary dendritic arm spacing, addition of Cu into pure aluminum as an alloying element favored a reduction in the average value of modulus of elasticity when compared with those observed for the Al–Ni alloy. It was found that the microhardness decreases with increasing tertiary dendritic arm spacings. On the other hand, solute addition of Cu into commercially pure aluminum favors a microhardness higher than that verified during upward unidirectional solidification of the Al-5.0 wt.% Ni alloy.
First record of the lesser horseshoe bat, Rhinolophus hipposideros (Borkhausen, 1797), in Libya and potential distribution in North Africa
Authors: Bendjeddou Mohammed Lamine , Bouam Idriss , Aulagnier Stéphane , Abdelaziz Seif E. , Etayeb Khaled , Mihalca Andrei Daniel , Sándor Attila D. 
Published: February 2022

Abstract
The lesser horseshoe bat has a broad distribution in warm temperate regions of Europe and Western Asia, and a patchy distribution in Africa. Common in the north-western part of North Africa, the species is missing more to the east. Hereby we report the first record in Libya, considerably extending its known geographic range. Additionally, we performed a species distribution modelling (SDM) analysis to explore its potential distribution in North Africa. The final SDM depicted a relatively well-known distribution and predicted that the suitable bioclimatic areas for this species are essentially found within the Mediterranean forests, woodlands, and scrub biome.
Solutions to a multi-phase model of sea ice growth
Authors: Tang Yangxin , Zheng Lin , Luan Liping 
Published: February 2022

Abstract
The multi-phase systems have found their applications in many fields. We shall apply this approach to investigate the multi-phase dynamics of sea ice growth. In this paper, the weak solution existence and uniqueness of parabolic differential equations are proved. Then large-time behavior of solutions is studied, and also the existence of the global attractor is proved. The key tool in this article is the energy method. Our existence proof is only in one dimension.
A study of minimax shrinkage estimators dominating the James-Stein estimator under the balanced loss function
Authors: Benkhaled Abdelkader , Hamdaoui Abdenour , Almutiry Waleed , Alshahrani Mohammed , Terbeche Mekki 
Published: February 2022

Abstract
One of the most common challenges in multivariate statistical analysis is estimating the mean parameters. A well-known approach of estimating the mean parameters is the maximum likelihood estimator (MLE). However, the MLE becomes inefficient in the case of having large-dimensional parameter space. A popular estimator that tackles this issue is the James-Stein estimator. Therefore, we aim to use the shrinkage method based on the balanced loss function to construct estimators for the mean parameters of the multivariate normal (MVN) distribution that dominates both the MLE and James-Stein estimators. Two classes of shrinkage estimators have been established that generalized the James-Stein estimator. We study their domination and minimaxity properties to the MLE and their performances to the James-Stein estimators. The efficiency of the proposed estimators is explored through simulation studies.
Quercitrin protects human bronchial epithelial cells from oxidative damage
Authors: Yu Dan , Wang Fan , Ye Shuming , Yang Shuo , Yu Ning , Zhou Xinyan , Zhang Nian 
Published: February 2022

Abstract
Chronic obstructive pulmonary disease (COPD) is mainly caused by cigarette smoking (CS), with oxidative stress being one key component during its pathogenesis. This study aimed to investigate the effects of quercitrin (QE) on cigarette smoke extract (CSE)-induced cell apoptosis and oxidative stress in human bronchial epithelial cells (HBECs) and its underlying mechanism. HBECs were treated with 2% CSE for 24 h to establish in vitro COPD cellular models. CCK-8 assay and flow cytometry analysis were performed to evaluate cell viability and apoptosis, respectively. Western blotting was applied to examine protein levels and ELISA kits were used to examine contents of the indicated oxidant/antioxidant markers. The results demonstrated that CSE promoted apoptosis and suppressed viability of HBECs and QE reversed these effects. CSE caused increase in T-AOC, superoxide dismutase, and glutathione (GSH) peroxidase contents and decrease in MDA, reactive oxygen species , and GSH contents in HBECs, which were rescued by QE treatment. The CSE-induced Nrf2 nuclear translocation and elevation of NAD(P)H: quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) expression were also reversed by QE in HBECs. The mitogen-activated protein kinase (MAPK) signaling was activated by CSE and further suppressed by QE in HBECs. Collectively, QE exerts a protective role in HBECs against cell apoptosis and oxidative damage via inactivation of the Nrf2/HO-1/NQO1 pathway and the MAPK/ERK pathway.
miR-29c-5p knockdown reduces inflammation and blood–brain barrier disruption by upregulating LRP6
Authors: Dai Qijun , Sun Jian , Dai Tianyi , Xu Qin , Ding Yueqin 
Published: February 2022

Abstract
Blood–brain barrier participates in the pathological process of ischemic stroke. MicroRNA-29c-5p was highly expressed in clinical samples from patients with ischemic stroke. In this study, oxygen-glucose deprivation (OGD) treatment of astrocytes enhanced the permeability of brain microvascular endothelial cells (BMECs), and the miR-29c-5p expression was elevated in clinical samples from patients with ischemic stroke. For the function of miR-29c-5p in ischemic stroke, the miR-29c-5p knockdown decreased the permeability and the tight junction protein (TJP) destruction of BMECs and ameliorated the inflammation induced by OGD-treated astrocytes. Mechanistically, miR-29c-5p interacted with lipoprotein receptor-related protein 6 (LRP6) and negatively regulated the LRP6 expression in astrocytes. Moreover, the rescue assays indicated that the interference with miR-29c-5p ameliorated the TJP destruction of BMECs and inflammation caused by OGD-treated astrocytes by increasing the LRP6 expression. Together, miR-29c-5p knockdown decreased the high permeability and the TJP destruction of BMECs and ameliorated the inflammation induced by OGD-treated astrocytes by elevating LRP6 expression.
A Progressive Build-up of Perineuronal Nets in the Somatosensory Cortex Is Associated with the Development of Chronic Pain in Mice
Authors: Mascio Giada , Notartomaso Serena , Martinello Katiuscia , Liberatore Francesca , Bucci Domenico , Imbriglio Tiziana , Cannella Milena , Antenucci Nico , Scarselli Pamela , Lattanzi Roberta , Bruno Valeria , Nicoletti Ferdinando , Fucile Sergio , Battaglia Giuseppe 
Published: February 2022

Chronic pain is sustained by a maladaptive form of neuronal plasticity occurring in all stations of the pain neuraxis, including cortical regions of the pain matrix. We report that chronic inflammatory pain induced by unilateral injection of complete Freund's adjuvant (CFA) in the hindpaw of male mice was associated with a progressive build-up of perineuronal nets (PNNs) in the contralateral somatosensory cortex (SSC), medial prefrontal cortex (mPFC), and reticular thalamic nucleus. In the SSC, the density of PNNs labeled by Wisteria floribunda agglutinin (WFA) was increased at both 3 and 7 d following CFA injection, but only after 7 d in the mPFC. The number of parvalbumin (PV)-positive interneurons enwrapped by WFA+/PNNs was also increased in all three brain regions of mice injected with CFA. Remarkably, PNN degradation induced by intracortical infusion of chondroitinase-ABC significantly reduced mechanical and thermal pain, and also reversed the increased frequency of IPSCs recorded in layer 5 pyramidal neurons of the contralateral SSC in CFA-injected mice. These findings suggest a possible relationship between cortical PNNs and nociceptive sensitization, and support the hypothesis that PNNs maintain their plasticity in the adult life and regulate cortical responses to sensory inputs.SIGNIFICANCE STATEMENTThe brain extracellular matrix not only provides structural support, but also regulates synapse formation and function, and modulates neuronal excitability. We found that chronic inflammatory pain in mice enhances the density of perineuronal nets (PNNs) in the somatosensory cortex and medial prefrontal cortex. Remarkably, enzymatic degradation of PNNs in the somatosensory cortex caused analgesia and reversed alterations of inhibitory synaptic transmission associated with chronic pain. These findings disclose a novel mechanism of nociceptive sensitization and support a role for PNNs in mechanisms of neuronal plasticity in the adult brain.
Efek Rebusan Sereh (Cymbopogon citratus) Terhadap Respon Stress Oksidatif Pada Tikus Wistar Jantan (Rattus norvegicus) Diabetes
Authors: Widaryanti Barinta , Khikmah Nur , Sulistyani Nunung 
Published: February 2022

Diabetes mellitus is a metabolic disorder with hyperglycemia. The amount of diabetic patients in Indonesia will increase rapidly without suitable treatment. High level of blood glucose will trigger oxidative stress. The objective of this research wa to investigate the effect of lemongrass on oxidative stress response that was indicated by serum and hepatic Total antioxidant capacity and Malondialdehyde level. Thirty male wistar rat were divided into five groups. K1 was a normal group, K2 was a normal group with lemongrass treatment, K3 was a diabetic group induced by a single dose of Streptozotocin at a concentration of 60 mg/kg body weight, K4 was a diabetic group that was treated with glibenclamid at a concentration of 0.09 mg/200 gr body weight, while K5 was a diabetic group treated with lemongrass at a concentration of 3.6 ml/200 gr body weight. The result showed that lemongrass was able to reduce blood glucose levels, serum MDA and hepatic MDA levels and increased the level of total antioxidant status

Diabetes adlah kelainan metabolisme yang ditandai dengan hiperglikemia. Jumlah penderita diabetes mellitus di Indonesia akan mengalami peningkatan jika tidak ada penanganan yang sesuai. Tinggi kadar glukosa darah dapat memicu terjadinya stress oksidatif. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian sereh terhadap respon stress oksidatif yang ditunjukan dengan kapasitas antioksidan total dan kadar malondialdehid. Tigapuluh ekor tikus wistar jantan dibagi menjadi lima kelompok. K1 adalah kelompok normal, K2 adalah kelompok normal dengan perlakuan sereh, K3 adalah kelompok diabetes yang diinduksi dengan streptozotocin 60 mg/kg berat badan single dose, K4 adalah kelompok diabetes yang diberi perlakuan dengan glibenklamid dengan dosis 0.09 mg/200 gr berat badan. Sedangkan K5 adalah kelompok diabetes yang dieri perlakuan dengan rebusan sereh dengan dosis 3.6 ml/200 gr berat badan. Hasil penelitian menunjukan bahwa rebusan sereh mampu menurunkan kadar glukosa darah, konsetrasi malondialdehid serum dan hepar, serta meningkatkan total antioksidan status pada serum dan hepar.
MIGRACIONES INTERNACIONALES CON ROSTRO HUMANO: UNA REFLEXIÓN ÉTICA DEL FENÓMENO
Authors: Franco Gaviria Luis Horacio 
Published: February 2022

El presente artículo tiene por objetivo central reconocer la condición humana del sujeto migrante, dándole voz para hablar desde su propia narrativa. Para ello nos focalizaremos en algunas nociones filosóficas como la libertad y la dignidad, centrándonos en el fenómeno humano lejos, por ahora, de las cifras que se han utilizado para estigmatizar las migraciones internacionales. El análisis de algunos textos filosóficos y la hermenéutica crítica, serán el eje Metodológico que nos permitirá contextualizar y relacionar a la filosofía moral con las migraciones. Como resultado se espera dar cuenta de la importancia que tiene la filosofía moral en los estudios migratorios para la humanización de un fenómeno que no es ni una amenaza ni una oportunidad; es, ante todo, una realidad que invita a pensarnos en sociedades más dinámicas. Una de las conclusiones a la que llegaremos será que la intensificación de los flujos migratorios es resultado de la crisis social, económica y política de muchos estados y no de los migrantes que con sus pasos construyen el escenario para redefinir el concepto de ciudadanía y de derechos humanos.
JUSTICIA TRANSICIONAL PARA LA SUPERACIÓN DEL DILEMA COLOMBIANO
Authors: ARIAS HENAO DIANA PATRICIA , Idrobo-Velasco Jhon Alexander , Jaime Ruiz Edwin Diomedes 
Published: February 2022

El presente artículo de reflexión tiene como objetivo analizar la justicia restaurativa desde la relación individuo-sociedad y dentro del proceso de paz específico con las Fuerzas Armadas Revolucionarias de Colombia, Farc-Ep. Recorre sus antecedentes históricos hasta la consecución de una Justicia Especial para la Paz – JEP, como modelo de justicia transicional. Con una metodología descriptiva que utiliza instrumentos cualitativos y comparativos de medición con otros procesos transicionales de justicia como el caso de Irlanda del Norte y Sudáfrica, se presentan resultados en materia de escenarios de construcción de paz. Se propone a la teoría política contemporánea como un marco de comprensión conceptual de la urgencia de un modelo de justicia que esté a la altura de las circunstancias y los tiempos colombianos.
Three-dimensional printing of scaffolds for facial reconstruction
Authors: Zhou Yuxiao , Grayson Warren 
Published: February 2022

AbstractThree-dimensional (3D) printing of scaffolds for tissue engineering applications has grown substantially in the past two decades. Unlike conventional autografts and allografts, 3D-printed scaffolds can satisfy the growing need for personalized bony reconstruction following massive craniofacial bone loss. Employing layer-by-layer manufacturing techniques, it is possible to produce patient-specific structures to rebuild complicated geometries for esthetic purposes and restore mechanical and respiratory functions. Here, we summarize the trends and current state-of-the-art studies in 3D-printing technologies for craniofacial bone reconstruction. We describe the design and development of the craniofacial scaffolds, including material choices, scaffold fabrication workflows, and the mechanical, structural, and biological considerations impacting scaffold application and function. Finally, we summarize the remaining hurdles and opportunities for growth to transition to the widespread clinical adoption of this technology.
Graphical abstract
Fault Source Model and Stress Changes of the 2021 Mw 7.4 Maduo Earthquake, China, Constrained by InSAR and GPS Measurements
Authors: Hong Shunying , Liu Mian , Liu Tai , Dong Yanfang , Chen Lize , Meng Guojie , Xu Yueren 
Published: February 2022

ABSTRACTOn 22 May 2021, an Mw 7.4 earthquake struck Maduo, China, within the eastern Bayan Har block of the Tibetan plateau. The eastward-extruding Bayan Har block is marked by active seismicity along its boundary faults, including the 2008 Mw 7.9 Wenchuan earthquake, but large earthquakes within the block are relatively rare. Thus, the Maduo earthquake could provide useful information about crustal deformation of the Tibetan plateau. Early reports, shortly after the earthquake, have suggested a sinistral strike-slip fault rupture, but the fault geometry and slip distribution vary in these models due to the limited observational constraints. Here, we reconstructed a model of fault geometry and coseismic slip using Interferometric Synthetic Aperture Radar and Global Positioning System data. A nonplanar fault model was constructed based on pixel-offset images and the optimized dip angle. The along-strike variation of the dip angle is small, so a single optimized dip is used. Our results suggest that the Maduo earthquake ruptured ∼156 km on a northwest-striking major fault that dips 78°, and ∼24 km on a minor southeast-striking fault that dips 64°. Most fault slip occurred above 15 km depth, and released a moment of ∼1.65×1020  N·m. Using the resolved fault source model, we calculated the change of coulomb failure stress in the region and on the neighboring faults. The Maduo earthquake highlighted intrablock deformation in the Tibetan plateau whereas numerous lithospheric blocks extrude along major strike-slip faults.