bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate Social Responsibility (CSR) and Socio-Economic Change of Post-Reclamation Community in South Wenang Urban Village, Manado City
Authors: Kerebungu Ferdinand , Fathimah Siti 
Published: September 2022

The reclamation of the beach in Manado city developed as a functional area resulted in a change in the face of the city in coastal areas. As a large company and taking up public space, it must give social responsibility to the community who are deprived of their area of social activity. The purpose of this paper is to review whether CSR programs have been implemented by the developer to communities affected by coastal reclamation and whether socio-economic changes have occurred in the community after coastal reclamation. This study uses a qualitative approach with data collection techniques through observation, interview, and documentation studies. The research found that CSR programs have not been implemented by developers, and there are significant socioeconomic changes among the fishing families after the reclamation taking place in the village of South Wenang. There is a change in the source of livelihood from fishermen to the informal sector (among others food stalls, selling pulses, stalls, retail gasoline sales, parking lots, construction workers). But from the change of livelihood source to the informal sector, the life of the fishing family has not improved significantly.
Bowongso Coffee Shop; More Than Just A Holiday and Place for Rural Youth Lifestyle in Indonesia
Authors: Muryanti Muryanti 
Published: September 2022

Subsistence farming is the main job of farmers in Bowongso Village, Wonosobo, Indonesia. Coffee is one of the commercial crops since it provides much profits and changes the pattern of agricultural management. The purpose of this paper was to find out how the creativity of youth in rural areas plays a role in developing agricultural innovation. Data were obtained from interviews with members of farmer groups, farmers, and consumers of the Bowongso coffee shop. The results showed that the commercialization of agriculture needs to be improved in increasing innovation and production to maintain the prosperity of rural communities. The Bowongso Coffee Shop is an innovation in the development of the agricultural sector from upstream to downstream driven by young farmers who are members of the Bina Sejahtera farmer group. The teenagers make coffee as a commercial plant and coffee shop as a place to gather and discuss the development of farmer groups or agricultural conditions in the village. The social movement of rural teenagers plays a role in the development of agriculture where they run coffee shops as a way of life for rural communities that are not much different from urban communities and further improve the village economy.
Pica Magz/Pica Fest: Creative Economy In Bali Subculture
Authors: Bastari Rendy Pandita , Resmadi Idhar , Utama Jiwa 
Published: September 2022

.Bali's creative economy in 2020 shows that 26.26% was dominated by music, 12.64% from performing arts, 8.29% from culinary, and 52.81% from other sub-sectors. By looking at the data, there are one sub-sector that is not quite as significant as the others and that is fashion. One subculture actor who is quite active in the local fashion industry is Pica, subdivided by Picamagz and Pica Fest. They are quite constant in holding subcultural events such as music shows and fashion festival. This proves that local fashion industry can give contribution and can also be supported by other industry. The purpose of this study is to analyze the social creative field of Picamagz and Pica Fest. The method used for this study is qualitative descriptive with the validation from interviews and observation. The result of this study shows that that the field of expression, production, dissemination and appreciation filled with active actors who holds their respective role.
Transcriptional comparison of testicular adrenal rest tumors with fetal and adult tissues
Authors: Schröder Mariska A M , Sweep Fred C G J , van Herwaarden Antonius E , Mitchell Rod T , Eliveld Jitske , van Pelt Ans M M , Rowan Alan E , Korbie Darren , Stikkelbroeck Nike M M L , Claahsen-van der Grinten Hedi L , Span Paul N 
Published: September 2022

Abstract

Background
Testicular adrenal rest tumors (TART) are a common complication of unknown cellular origin in patients with congenital adrenal hyperplasia (CAH). These benign tumors have both adrenal and testicular characteristics and are hypothesized to either derive from cells of adrenal origin from the fetal adrenogonadal primordium or by atypical differentiation of adult Leydig-progenitor cells.

Objective
This study aims to unravel the identity and etiology of TART.

Methods
Co-expression of adrenal-specific CYP11B1 and Leydig cell-specific HSD17B3 in TART was studied using immunohistochemistry. We studied the possibility of TART being derived from atypical differentiation of adult Leydig-progenitor cells by the quantification of adrenal-specific enzyme expression upon adrenocorticotrophic hormone (ACTH)-like stimulation of ex vivo cultured platelet-derived growth factor receptor alpha-positive cells. By comparing the transcriptome of TART (n = 16) with the transcriptome of fetal adrenal (n = 13), fetal testis (n = 5), adult adrenal (n = 11), and adult testis (n = 10) tissues, we explored the identity of TART.

Results
We demonstrate co-expression of adrenal-specific CYP11B1 and testis-specific HSD17B3 in TART cells, indicating the existence of a distinct TART cell exhibiting both adrenal and testicular characteristics. Ex vivo cultured adult Leydig-progenitor cells did not express the ACTH-receptor MC2R but did express CYP11B1 upon stimulation. Unsupervised clustering of transcriptome data showed that TART was most similar to adult adrenal tissue, followed by adult testis tissue, and least similar to either fetal tissue.

Conclusion
Our data suggest that TART is induced — most likely via activation of a cAMP/protein kinase A-dependent receptor — from a progenitor cell into a unique mature adrenal-like cell type, sometimes exhibiting both adrenal and testicular features.
Deoxyelephantopin alleviates lipopolysaccharide-induced septic lung injury through inhibiting NF-ĸB/STAT3 axis
Authors: Wang Shu , Chen Yuefeng 
Published: September 2022

Sepsis induces multiple organ dysfunction syndromes, such as acute kidney, liver, or lung injury. Septic lung injury is associated with excessive apoptosis and inflammatory responses in hepatocytes. Deoxyelephantopin is a sesquiterpene lactone found in Elephantopus scaber L, and has immunomodulatory, antibacterial, anti-inflammatory, and antifungal properties. The role of deoxyelephantopin in sepsis-associated lung injury was investigated. First, human bronchial epithelial cells (BEAS-2B) and human pulmonary artery endothelial cells (HPAEC) were treated with lipopolysaccharide to induce cytotoxicity. Treatment with lipopolysaccharide reduced cell viability of BEAS-2B and HPAEC, and promoted cell apoptosis through down-regulation of poly (ADP-ribose) polymerase (PARP) and B-cell lymphoma 2 (Bcl-2), and up-regulation of cleaved PARP and B-cell lymphoma-associated X protein (Bax). Second, lipopolysaccharide-treated BEAS-2B and HPAEC were incubated with increasing concentrations of deoxyelephantopin, that is, 1, 5, or 10 μM. Deoxyelephantopin enhanced cell viability and reduced cell apoptosis of lipopolysaccharide-treated BEAS-2B and HPAEC. Third, deoxyelephantopin attenuated lipopolysaccharide-induced decrease of superoxide dismutase and glutathione, and increase of malondialdehyde and myeloperoxidase in BEAS-2B and HPAEC. Moreover, deoxyelephantopin also weakened lipopolysaccharide-induced increase of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. Finally, deoxyelephantopin decreased protein expression of p-p65 and p-signal transducer and activator of transcription 3 (STAT3) in lipopolysaccharide-treated BEAS-2B and HPAEC. In conclusion, deoxyelephantopin exhibited anti-oxidative and anti-inflammatory effects against lipopolysaccharide-treated BEAS-2B and HPAEC through inactivation of nuclear factor kappa B/STAT3 signaling.
Cornus iridoid glycoside alleviates sepsis-induced acute lung injury by regulating NF-κB and Nrf2/HO-1 pathways
Authors: Tang Xuhui , Tang Haimin 
Published: September 2022

Background: Sepsis-induced acute lung injury (ALI) is a syndrome associated with inflammation. Cornus iridoid glycoside (CIG), a bioactive component isolated from Corni Fructus, exhibits anti-inflammatory activities. However, the function and underlying mechanisms of CIG in mice with sepsis-induced ALI remain elusive.
Methods: The sepsis-elicited ALI model of mice was established by the induction of cecal ligation and puncture (CLP). The wet/dry (W/D) ratio of lung tissues was examined, and the pathological alterations were determined by hematoxylin and eosin staining. The messenger RNA (mRNA) expressions and serum levels of Interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured by reverse transcription-quantitative polymerase chain reaction and enzyme-linked immunosorbent serologic assay, respectively. The concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were assessed by biochemical kits. In addition, the relative protein levels of p-p65, p65, phosphorylated- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (p-IκBα), IκBα, nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) gene were analyzed by Western blotting analysis.
Results: CLP enhanced W/D ratio and aggravated pathological changes and scores in mice, which were obviously alleviated by the two concentrations of CIG treatment. CIG treatment notably decreased the CLP-induced mRNA expressions and serum levels of IL-1β, IL-6, TNF-α, and MDA, but enhanced the decreased concentrations (caused by CLP) of SOD and GSH-Px. Moreover, CIG treatment significantly decreased the ratios of p65/p-p65 and IκBα/p-IκBα caused by CLP, but aggravated the CLP-induced relative protein levels of Nrf2 and HO-1.
Conclusions: CIG obviously ameliorated the sepsis-induced ALI in mice by suppressing inflammation and oxidative stress, which was closely associated with nuclear factor kappa B (NF-κB) and Nrf2–HO-1 signaling pathways.
Cinnamtannin D1 ameliorates DSS-induced colitis by preventing Th17/Treg imbalance through activation of the AMPK/mTOR pathway
Authors: Yang Ying Xue , Yuan Yuan , Xia Boning 
Published: September 2022

Background: Inflammatory bowel disease (IBD) is a chronic idiopathic gastrointestinal disease, including ulcerative colitis (UC) and Crohn’s disease (CD), which is typically characterized by chronicity and relapse. Cinnamtannin D1 (CTD1), extracted from Cinnamomum tamala, has been found to exert good immunosuppressive activity. However, the role of CTD1 in IBD is unclear.
Methods: The colitis mice model was established by dextran sulfate sodium (DSS) treatment. Protein levels (p-STAT3/STAT3, ROR-γt, p-STAT5/STAT5, FOXP3, p-AMPK/AMPK, and p-mTOR/mTOR) were examined using Western blotting analysis. Changes in histopathology were detected through hematoxylin and eosin staining. The proportion of T helper 17 (Th17) cells and regulatory T (Treg) cells was measured by flow cytometry analysis.
Results: CTD1 improved body weight and colon length, and alleviated inflammation and histological damage in DSS-induced colitis mice model. DSS treatment also demonstrated a negative effect on Th17–Treg cells balance whereas CTD1 restored the balance of Th17– Treg cells in DSS-induced colitis mice model. Regulatory factors (such as STAT3, ROR-γt, STAT5, and FOXP3) that closely related to the balance of Th17–Treg cells were regulated by CTD1. In addition, AMPK phosphorylation was increased and mTOR phosphorylation was inhibited by CTD1 in DSS-induced colitis mice model.
Conclusion: These findings established that CTD1 improved DSS-induced colitis by suppressing Th17–Treg cells balance by activating the AMPK/mTOR pathway. This study provided a new strategy for developing novel treatments for patients with IBD.
Zeaxanthin attenuates OVA-induced allergic asthma in mice by regulating the p38 MAPK/β-catenin signaling pathway
Authors: Jin Xiaosheng , Jin Weijing , Li Guoping , Zheng Jisheng 
Published: September 2022

Background: Asthma is a heterogeneous and complex chronic airway disease with a high incidence rate, characterized by chronic airway inflammation. Although the anti-inflammatory effect of zeaxanthin has been demonstrated in various disease models, its explicit role in allergic asthma remains elusive.
Methods: An allergic asthma model was established by ovalbumin (OVA) stimulation in BALB/c nude mice. The pathological examination, collagen deposition and expression of α-smooth muscle actin (α-SMA) in lung tissues were determined by hematoxylin and eosin (H&E), MASSON and immunofluorescence staining, respectively. Besides, the effect of zeaxanthin on inflammation and oxidative stress was assessed by the enzyme-linked immunosorbent assay (ELISA) and spectrophotometry measure. Moreover, the underlying mechanism was analyzed by detecting the expression of phosphorylated p38 (p-p38), p38, β-catenin, p-c-Jun N-terminal kinase (p-JNK) and JNK with western blot assays.
Results: The distinct infiltration of inflammatory cells was observed in the OVA-induced asthma mice model with significantly increased concentrations of immunoglobulin E (IgE), interleukin-4 (IL-4), IL-5, IL-13 and eotaxin (p˂0.001), which were prominently reversed by zeaxanthin treatment (p˂0.001). In addition, zeaxanthin treatment decreased the OVA-induced collagen deposition and α-SMA expression. A similar inhibitory effect of zeaxanthin on the oxidative stress was also observed in the OVA-induced asthma mice model, as evidenced by the prominent decrease of malondialdehyde (MDA) concentration and the remarkable increase of superoxide dismutase (SOD), glutathione S transferase (GST) and Glutathione (GSH) concentrations (p˂0.001). Moreover, zeaxanthin introduction markedly reduced the relative expressions of p-p38/p38, β-catenin and p-JNK/JNK in the OVA-induced asthma mice model (p˂0.001), indicating that zeaxanthin suppressed the p38 mitogen-activated protein kinase (p38 MAPK)/β-catenin signaling pathway in the OVA-induced asthma mice model.
Conclusions: Zeaxanthin attenuated OVA-induced allergic asthma in mice via modulating the p38 MAPK/β-catenin signaling pathway.
Investigating the early impacts of the COVID-19 pandemic on modifiable risk factors for cancer and chronic disease: a repeated cross-sectional study in Alberta, Canada
Authors: Jessiman-Perreault Geneviève , Li Alvin , Frenette Nicole , Allen Scott Lisa 
Published: September 2022

Abstract
Objectives
This study contributes to empirical evidence by examining the impact of the first and second waves of the COVID-19 pandemic on modifiable risk factors (MRF) and whether these patterns differ according to level of material deprivation among people living in Alberta.

Methods
Using data from a repeated cross-sectional provincial health survey (Alberta Community Health Survey (ACHS): 2018–2021), we conducted logistic regression analyses examining the impacts of the COVID-19 pandemic on meeting national guidelines on four MRFs (tobacco use, physical activity, fruit and vegetable consumption, alcohol use) (n=11,249). We compared population-level changes in MRFs from one year before the COVID-19 pandemic (March 2019–February 2020) to one year during the pandemic (March 2020–February 2021) in Alberta. We also assessed whether these trends differed by a measure of material deprivation.

Results
Compared to the pre-COVID-19 period, the fully adjusted odds of meeting recommended guidelines for fruit and vegetable consumption (OR=0.42) decreased during the pandemic. Individuals experiencing high material deprivation had lower odds of meeting recommended guidelines for physical activity (OR=0.65) and higher odds of not being current tobacco users (OR=1.36) during the pandemic versus during the pre-pandemic period.

Conclusion
At a population level, analyses from the ACHS showed minimal impacts of the first year of the COVID-19 pandemic on MRFs, besides fruit and vegetable consumption. Yet, stratifying results showed statistically significant differences in pandemic impacts on MRFs by level of material deprivation. Therefore, understanding the influence of material deprivation on MRFs during the pandemic is key to tailoring future public health interventions promoting health and preventing cancer and chronic disease.
En Bloc Resection of Cervical Spine Osteoid Osteoma With O-Arm–Assisted 3D Navigation
Authors: Chitta Shashank , Russo Trevor L. , Albert Andrew J. , Russo Scott S. , MacFarlane Jarrod J. , Janish Tyler J. 
Published: September 2022

Case:
A 22-year-old man presented with long-standing, progressive neck pain of unknown etiology. Investigation revealed a cervical spine osteoid osteoma affecting the right C4-5 facet joint. He underwent minimally invasive en bloc resection with O-arm–assisted 3-dimensional navigation without introducing iatrogenic spinal instability. Symptoms resolved after surgery, without recurrence or instability at the 2-year follow-up.

Conclusion:
Cervical spine osteoid osteoma is a tumor that presents diagnostic and therapeutic challenges. Achieving precise, complete resection of the tumor with a minimally invasive approach while avoiding spinal instrumentation and arthrodesis is paramount to excellent surgical outcomes.
Degradation and fragmentation behavior of polypropylene and polystyrene in water.
Authors: Nakatani Hisayuki , Ohshima Yuina , Uchiyama Taishi , Suguru Motokucho 
Published: September 2022

Abstract
A polystyrene (PS) retrieved from the beach exhibited no change in surface texture. In contrast to it, a retrieved polypropylene (PP) had a rumpled surface texture. Highly reactive sulfate radical generated by K2S2O8 was employed as degradation initiator of PP and PS, and their degradation behavior was studied in water. The PS carbonyl index value gradually went up down, and its molecular weight (MW) curve discontinuously shifted to a lower MW with the increase of the degradation time unlike the PP. It was found that PP microplastic production rate was approximately three time higher than PS from weight ratio dependence on degradation time. The higher microplastic production rate of PP arose from its crystallizability. The voids were produced by change in specific volume occurring by chemi-crystallization and then provoked the cracks leading to quick fragmentation. The SEM photographs suggested that the PP microplastic size facilely reached nm order by the cracking around lamella.
Differentiation of intestinal epithelial stem cells from parthenogenetic embryonic stem cells
Authors: Wang Zhiqiang , Li Leilei , Wang Wanpu , Luo Lilin , Dong Shuai , Li Menglong , Chen Tianxing , Meng Qingyang , Liang Rui 
Published: September 2022

Abstract
Intestinal epithelial stem cells (IESCs) have great potential for the repair of intestinal epithelial injury. However, the amplification of primarily cultured IESCs is relatively difficult. This study aims to obtain IESCs by inducing the differentiation of human parthenogenetic embryonic stem cells (hPESCs). The differentiation of hPESCs into to the definitive endoderm (DE) was performed by using activin A and Wnt3a firstly. Then the differentiation of DE into IESCs was conducted in the presence of epidermal growth factor (EGF). Markers of IESCs, i.e., Musashi 1(Msil) and hairy and enhancer of split 1(Hes1), were monitored dynamically with double immunocytochemical staining and real-time quantitative PCR (qPCR) to identify the differentiation of IESCs. Results showed that Msil+Hesl+ IESCs culminated after a 5-day culture in the presence of EGF and the expression of Msil and Hes1 in cells treated by EGF was 51.3- and 45.38-fold times, respectively, higher than those not treated by EGF. There results demonstrate that IESCs can be generated by inducing the differentiation of hPESCs. Therefore, this study provides a potential source of IESCs for the regeneration of injured intestinal epithelia and the theoretical and experimental basis for the clinical application of hPESCs.
Fully on-chip photonic turnkey quantum source for entangled qubit/qudit state generation
Authors: Mahmudlu Hatam , Johanning Robert , Kashi Anahita , Rees Albert van , Epping Jörn , Haldar Raktim , Boller Klaus , Kues Michael 
Published: September 2022

Abstract
Integrated photonics has recently become a leading platform for the realization and processing of optical entangled quantum states in compact, robust, and scalable chip formats with applications in long-distance quantum-secured communication, quantum-accelerated information processing, and non-classical metrology. However, the quantum light sources developed so far have relied on external bulky excitation lasers making them impractical, not reproducible prototype devices, hindering scalability and the transfer out of the lab into real-world applications. Here we demonstrate a fully integrated quantum light source, which overcomes these challenges through the combined integration of a laser cavity, a highly efficient tunable noise suppression filter (> 55 dB) exploiting the Vernier effect, and a nonlinear microring for entangled photon pair generation through spontaneous four-wave mixing. The hybrid quantum source employs an electrically-pumped InP gain section and a Si₃N₄ low-loss microring filter system and demonstrates high-performance parameters, i.e., a pair emission over four resonant modes in the telecom band (bandwidth ∼ 1 THz), and a remarkable pair detection rate of ∼ 620 Hz at a high coincidence-to-accidental ratio of ∼80. The source directly creates high-dimensional frequency-bin entangled quantum states (qubits/qudits), verified by quantum interference measurements with visibilities up to 96% (violating Bell-inequality) and by density matrix reconstruction through state tomography showing fidelities of up to 99%. Our approach, leveraging a hybrid photonic platform, enables commercial-viable, low-cost, compact, light-weight, and field-deployable entangled quantum sources, quintessential for practical, out-of-lab applications, e.g., in quantum processors and quantum satellite communications systems.