bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antecedentes y ceremonial de los matrimonios militares en España
Authors: Eiroa Escalada Javier , Bolivar Martín Juan José 
Published: January 2022

Nuestra sociedad suele tener la necesidad de exteriorizar y solemnizar los momentos culminantes de la vida, siendo el matrimonio uno de ellos. Hay numerosas publicaciones relacionadas con el matrimonio civil, pero son muy escasas las relacionadas con el ámbito militar.
Las Fuerzas Armadas siempre se han considerado como un colectivo especial, pero como integrantes de la sociedad no son ajenos a los cambios producidos a lo largo de la historia de España.
Este trabajo aborda las singularidades del matrimonio militar. En la primera parte, este artículo analiza la evolución histórica y normativa del matrimonio militar en España. En la segunda parte, para enmarcar el tema, se recoge la normativa vigente de aplicación en la materia, considerándose los aspectos generales desde los puntos de vista civil y eclesiástico y, de manera específica, el ámbito militar.
Finaliza el trabajo detallando y analizando los distintos momentos en el protocolo y en el ceremonial concreto de una boda militar en la actualidad.
¿Buena praxis profesional o dinero fácil?
Authors: Serrano Martin Carlos , López Redondo Isaac , Arumburu Moncada Luisa Graciela 
Published: January 2022

Objetivo: Ante las recientes campañas gubernamentales para concienciar a la población en contra de las Fake News, vemos en el cine una herramienta didáctica ideal para estudiar la representación que el séptimo arte ha realizado del ámbito de la empresa informativa bajo las siguientes cuestiones: ¿Qué caminos y estrategias toman las empresas de la información para ganar la credibilidad de la audiencia? ¿Cómo se adaptan a las continuas novedades del gremio informativo según el séptimo arte?
Diseño/metodología/enfoque: Elegimos el cine europeo como ámbito geográfico a investigar debido a que consideramos que hay una sobreexplotación del cine norteamericano como fuente de estudio para analizar la relación entre cine y periodismo. Esta situación hace necesario buscar otras filmografías que aportan al imaginario colectivo grandes títulos no estudiados con la profundidad precisa. Hemos tratado los filmes analizados como fuente primaria, si recurrimos a terminología propia de los estudios históricos, para que responda lo manifiesto del metraje a las preguntas de la investigación. Nuestra muestra está formada por cinco películas. Un 80% de las producciones son europeas: The Program, Corresponsales Especiales, The Eichmann Show y Sympathy for the Devil. El 20% restante es una producción estadounidense: Nightcrawler.
Resultados: Los resultados desvelan que existe una gran diferencia entre los objetivos de la empresa informativa y las metas que desean alcanzar los profesionales de la comunicación. El principal punto de esta diferencia reside, principalmente, en que el brazo económico del medio en cuestión socava los principios de servicio público perseguidos por una gran mayoría de profesionales de la comunicación.
Limitaciones/implicaciones: El marco temporal europeo abarcado en estas líneas comienza en el año 2006 y finaliza en 2019. El único ejemplo estadounidenses es el filme Nightcrawler (2014).
Bioinformatics analysis and identification of hub genes and immune-related molecular mechanisms in chronic myeloid leukemia
Authors: Yao Fangyi , Zhao Cui , Zhong Fangmin , Qin Tingyu , Li Shuqi , Liu Jing , Huang Bo , Wang Xiaozhong 
Published: January 2022

Background
Chronic myeloid leukemia (CML) is a malignant hyperplastic tumor of the bone marrow originating from pluripotent hematopoietic stem cells. The advent of tyrosine kinase inhibitors (TKIs) has greatly improved the survival rate of patients with CML. However, TKI-resistance leads to the disease recurrence and progression. This study aimed to identify immune-related genes (IRGs) associated with CML progression.

Methods
We extracted the gene’s expression profiles from the Gene Expression Omnibus (GEO). Bioinformatics analysis was used to determine the differentially expressed IRGs of CML and normal peripheral blood mononuclear cells (PBMCs). Functional enrichment and gene set enrichment analysis (GSEA) were used to explore its potential mechanism. Hub genes were identified using Molecular Complex Detection (MCODE) and the CytoHubba plugin. The hub genes’ diagnostic value was evaluated using the receiver operating characteristic (ROC). The relative proportions of infiltrating immune cells in each CML sample were evaluated using CIBERSORT. Quantitative real-time PCR (RT-qPCR) was used to validate the hub gene expression in clinical samples.

Results
A total of 31 differentially expressed IRGs were identified. GO analyses revealed that the modules were typically enriched in the receptor ligand activity, cytokine activity, and endopeptidase activity. KEGG enrichment analysis of IRGs revealed that CML involved Th17 cell differentiation, the NF-kappa B signaling pathway, and cytokine-cytokine receptor interaction. A total of 10 hub genes were selected using the PPI network. GSEA showed that these hub genes were related to the gamma-interferon immune response, inflammatory response, and allograft rejection. ROC curve analysis suggested that six hub genes may be potential biomarkers for CML diagnosis. Further analysis indicated that immune cells were associated with the pathogenesis of CML. The RT-qPCR results showed that proteinase 3 (PRTN3), cathepsin G (CTSG), matrix metalloproteinase 9 (MMP9), resistin (RETN), eosinophil derived neurotoxin (RNase2), eosinophil cationic protein (ECP, RNase3) were significantly elevated in CML patients’ PBMCs compared with healthy controls.

Conclusion
These results improved our understanding of the functional characteristics and immune-related molecular mechanisms involved in CML progression and provided potential diagnostic biomarkers and therapeutic targets.
Functional genetic variants in complement component 7 confer susceptibility to gastric cancer
Authors: Wang Siyue , Hu Wenqian , Xie Yuning , Wu Hongjiao , Jia Zhenxian , Zhang Zhi , Zhang Xuemei 
Published: January 2022

Background
Complement system plays an important role in innate immunity which involved in the changes tumor immune microenvironment by mediating the inflammatory response. This study aims to explore the relationship between complement component 7 (C7) polymorphisms and the risk of gastric cancer (GC).

Materials and Methods
All selected SNPs of C7 were genotyped in 471 patients and 471 controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional Logistic regression to analyze the relationship between each genotype and the genetic susceptibility to gastric cancer. The level of C7 expression in GC was analyzed by Gene Expression Profiling Interactive Analysis (GEPIA) and detected by Enzyme Linked Immunosorbent Assay. Kaplan–Meier plotter were used to reveal C7 of prognostic value in GC. We examined SNPs associated with the expression of C7 using the GTEx database. The effect of C7 polymorphisms on the regulatory activity of C7 was detected by luciferase reporter assay.

Results
Unconditional logistic regression showed that individuals with C7 rs1376178 AA or CA genotype had a higher risk of GC with OR (95% CI) of 2.09 (1.43–3.03) and 1.88 (1.35–2.63), respectively. For C7 rs1061429 C > A polymorphism, AA genotype was associated with the elevated risk for developing gastric cancer (OR = 2.16, 95% CI [1.37–3.38]). In stratified analysis, C7 rs1376178 AA genotype increased the risk of GC among males (OR = 2.88, 95% CI [1.81–4.58]), but not among females (OR = 1.06, 95% CI [0.55–2.06]). Individuals carrying rs1061429 AA significantly increased the risk of gastric cancer among youngers (OR = 2.84, 95% CI [1.39–5.80]) and non-smokers (OR = 2.79, 95% CI [1.63–4.77]). C7 was overexpressed in gastric cancer tissues and serum of cancer patients and was significantly associated with the prognosis. C7 rs1061429 C > A variant contributed to reduced protein level of C7 (P = 0.029), but rs1376178 didn’t. Luciferase reporter assay showed that rs1376178C-containing plasmid exhibited 2.86-fold higher luciferase activity than rs1376178 A-containing plasmid (P < 0.001). We also found that rs1061429A allele contributed 1.34-fold increased luciferase activity than rs1061429C allele when co-transfected with miR-591 (P = 0.0012).

Conclusions
These findings highlight the role of C7 in the development of gastric cancer.
Australian chiropractic and osteopathic graduates' perceptions of readiness for transition to practice
Authors: Haworth Navine G. , Horstmanshof Louise , Moore Keri M. 
Published: January 2022

ABSTRACT

Objective
This is the second phase of a project. The aim was to explore Australian chiropractic and osteopathic new graduates' readiness for transition to practice concerning their clinical skills, professional behaviors, and interprofessional abilities. Phase 1 explored final year students' self-perceptions, and this part uncovered their opinions after 6 months or more in practice.

Methods
Interviews were conducted with a self-selecting sample of phase 1 participant graduates from 2 Australian chiropractic and 2 osteopathic programs. Results of the thematic content analysis of responses were compared to the Australian Chiropractic Standards and Osteopathic Capabilities, the authority documents at the time of the study.

Results
Interviews from graduates of 2 chiropractic courses (n = 6) and 2 osteopathic courses (n = 8) revealed that the majority had positive comments about their readiness for practice. Most were satisfied with their level of clinical skills, verbal communication skills, and manual therapy skills. Gaps in competence were identified in written communications such as case notes and referrals to enable interprofessional practice, understanding of professional behaviors, and business skills. These identified gaps suggest that these graduates are not fully cognizant of what it means to manage their business practices in a manner expected of a health professional.

Conclusion
This small study into clinical training for chiropractic and osteopathy suggests that graduates lack some necessary skills and that it is possible that the ideals and goals for clinical education, to prepare for the transition to practice, may not be fully realized or deliver all the desired prerequisites for graduate practice.
To Assess the Effectiveness of Video Assisted Teaching Programme on Knowledge Regarding Prevention of COVID-19 among Antenatal Mother
Authors: Moon Shalini H. , Pada Biswas Anupriya Krishna , Prakashrao Bombale Maheshwari , Shradrao Bhalkar Shubhangi , Vijayrao Bhokre Sai , Devendra K. Pahune 
Published: January 2022

Introduction: Since the year 2019, COVID-19 (Corona Virus Disease 2019) has sparked numerous discussions and rumours. Undoubtedly, the core foundation of health care system has been shattered due to the absence of any specific treatments. Hence, this research study is selected and will be carried out to prevent the pandemic by providing knowledge through video assisted teachings to the antenatal mothers.
Aim: To assess the effectiveness of video assisted teaching programme on knowledge regarding prevention of COVID-19 among antenatal mothers in selected maternity hospitals.
Methodology: This study will be based on a Quantitative research approach along with the use of non-probability convenient sampling technique. The sample population will consist of 400 antenatal mothers from selected maternity hospital. Lesson plan and structured questionnaires will contribute to the context of V.A.T.P.
Expected Result: The study should be able to depict the positive effect of video-assisted teaching programme on prevention of COVID-19 among antenatal mothers from selected maternity hospitals, along with studying the association of their knowledge score to the respective demographic variables.
Conclusion: Video-assisted teaching programme should be effective method for delivering health education at all times and final conclusion will be drawn from the ultimate results of the statistical review.
Prevalence of Helicobacter Pylori Infection in Patients with Chronic Dyspeptic Symptoms at Rawal General and Dental Hospital, Islamabad
Authors: Abbasi Anwar Hussain , Andaleeb Hina , Alam Beenish Batool , Ahmed Khawaja Ashfaq , Yousuf Nadeem , Sajjad Subaika Noreen 
Published: January 2022

Background: Helicobacter Pylori infection is the most common cause of chronic dyspeptic symptoms all over the world and covers more than 60% of the out-patient department’s (OPD) registry. That is why we aimed to conduct this study to determine the prevalence of helicobacter pylori infection in patients with chronic dyspeptic symptoms visiting at our out-patient department (OPD) of Rawal General and Dental Hospital.
Methods: This was a descriptive cross-sectional hospital based study conducted in the Department of Gastroenterology, Rawal General and Dental Hospital, Islamabad between the periods of two years June 2018 – June 2020 with in patients who presented with a chief complain of dyspepsia through a consecutive sampling technique. Baseline and clinical variables were collected and correlated with the presence and absence of H. pylori infection among 355 finally recruited participants.
Results: The overall prevalence of H. pylori infection was 59.71% (n = 212). Among them, married males were more common. Positive H. pylori patients were younger than negative H. pylori patients, 40.24±6.62 vs. 44.9±8.05 (p 0.04). Participants who had a history of NSAIDS intake for past 7 days were significantly associated with positive H. pylori infection, 54.24% (n = 115), p 0.02. While on the other hands, patients who were receiving proton pump inhibitor for the past 4 weeks were significantly associated with absence of H. pylori infection when they presented with chronic dyspeptic symptoms, 65.03% (n = 93), p 0.01.
Conclusions: Our study has found that almost two third of the population suffering from chronic dyspeptic symptoms had positive H. pylori infection and these patients are younger than H. pylori negatives. Chronic NSAID users have direct relation in increased prevalence of H. pylori detection while use of PPI plays safety role in prevention and reducing of H. pylori infection.
Comparative Clinicopathological Study on pH and Haemoglobin of Blood
Authors: Vikraman K. S. , Sinduja Palati , Priyadharshini R. 
Published: January 2022

Aim: Aim of this study to compare the pH and hemoglobin of blood on different genders and different age groups.
Introduction: The full form of pH is the potential of hydrogen, pH is known as the negative logarithm of H+ ion concentration. The pH of any components of body, including blood, is indicated on the pH scale. The value of pH ranges from 0 to 14. A pH value of 7.0 is considered as neutral. Blood is slightly basic; the normal pH level of blood is 7.35 to 7.45. Usually, the body maintains the pH of blood close to 7.40. Hemoglobin is a protein molecule that helps the RBC to transport oxygen. The term heme reforms to the iron-containing porphyrin. This iron-containing hemoglobin is responsible for the red color of the red blood cells.
Materials and Methods: 15 blood samples were collected from the lab in Saveetha Dental College and Hospitals. The low sample size is one of the limitations. The pH value is measured by using a multi reagent strip, hemoglobin level was measured by using an automated counter machine, and these values were plotted. The pH value was tabulated and the data were analyzed with SPSS version (23.0).
Results: Mean hemoglobin value was observed different in different age group. In age groups of 21-30 years, the value was 12.95g/dl, in age groups 31-40 years the value was 12.08g/dl, in age groups of 41 to 50 years the value is 13.20g/dl and for age group more than 50 years the value is 14.05g/dl. Mean pH value on comparing with age, the value of pH was 7 for the age group of 21-30 years, 31-40 years was 7, 41 to 50 years was 7.04 and for more than 50 years was 7. Correlation analysis reveals no significant relationship between hemoglobin and pH with increasing age in both males and females.
Conclusion: The value of hemoglobin is increased among different age groups and the pH level remains the same and on comparing with gender the hemoglobin level increases with age group and pH remains the same.
Factors Affecting Uptake of Vitamin D in Gastro-Intestinal Tract
Authors: Kumar Abhishek , Garg Swati , Shukla Samarth , Acharya Sourya , Vagha Sunita 
Published: January 2022

Vitamin D deficiency affects about 50% of entire people. Vitamin D deficiency affects an estimated 100 million individuals worldwide, spanning all cultures and age groups. This catastrophic situation of vitamin D deficiency can mainly be attributed to lifestyle and the average impact that cuts down exposure to rays from the sun. It is required for the epithelium to produce vitamin D with the help of ultraviolet B (UVB). In comparison to fair-skinned people, dark-skinned people absorb a larger quantity of UVB in their epidermal melanin. Fairer folks require more solar exposition to get the same amount.
The increased cases of vitamin D deficiency is a significant prevalent ailment caused by vitamin D deficiency. It is a self-governing, deadly cause of widespread mortality worldwide. New research supports hypovitaminosis D as a cause of neoplastic, cardiac, orthopedic, immunological, NIDDM, and mental disorders. Vitamin D doses are usually compounded to a minimum of 1000 IU by physicians. According to a 2007 study, a high vitamin D intake decreases mortality risk. We've focused on vitamin D research and abstracted the mechanisms that have been linked to vitamin D and its therapeutic implications.
Vitamin D is unique in that it may be produced from the epidermis in reaction to UV radiation. AFTER IRRADIATING THE ERGOSTEROL TO UV LIGHT, Vitamin D2 is produced in sun-irradiated fungus. When UVB sunlight strikes the epidermis, vitamin D3 is produced. It's the most "natural" recipe possible. Humans produce vitamin D2. Vitamin D3 is produced mainly by oil-rich fish. Chylomicrons are generated when vitamin D is taken orally.
A review on Ocular Tuberculosis: Epidemiology, Clinical Features and Treatment
Authors: Singh Rakshit Kumar , Bewtra Chehak , Kher Praveena 
Published: January 2022

Background: globalization and migration movements are intimately linked to the expansion of tuberculosis. Tuberculosis has also been the primary cause of death in patients with HIV infection and the leading cause of death related to antibiotic resistance. Tuberculosis may affect any part of the uveal tract. T cell activity is of significance in Tuberculous infection. The phagocytosis of bazillion by macrophage is a significant factor in limiting the spread of infection. However, in patients who have had a previous tuberculous infection, the cell-mediated response is also associated with tissue damage due to the direct effect of sensitized T lymphocytes on the cell containing the ingested bacilli. Ocular tuberculosis is extrapulmonary tuberculosis with a wide range of symptoms. Tuberculosis is considered to infect the lungs of the patients in 80% of cases, and 20% of cases affect other organs like the eye. Ocular tuberculosis is an infectious disease with bacterial etiology that has a chronic case with a poor prognosis. Even the most effective treatment can cause vision loss, and clinical recovery is not always permanent. Ocular tuberculosis frequently results in permanent impairment, lowering patients' quality of life.
Objective: This article reports the various known presentations of ocular TB and reviews essential epidemiology, diagnosis, and treatment elements.
Methodology: The present study is a systematic review of literature searched from electronic databases and highly reputed websites like PubMed, researchgate, Elsevier, etc. Medical Subject Headings (MeSH) and the trial registry in the English language.
Conclusion: Ocular tuberculosis (OTB) diagnosis and treatment are difficult to come by. The disease's current uncertainty is due to mixed ocular tissue involvement, a lack of consensus on best practice diagnostic tests, and global variations in medical management. The present evaluation intends to provide an update on OTB's recent progress.
Post Mastectomy and Radiation Therapy - Complex Regional Pain Syndrome -A Case Report
Authors: Tople Jeshnu Prakash , Krishnendu S. 
Published: January 2022

Complex regional pain syndrome which is a rare syndrome following an injury or trauma, is an extremely painful condition. Diagnosis of this condition is not easy. They present with various symptoms like allodynia, hyperalgesia, asymmetry of temperature and sweating ,restricted range of motion. Identifying and treating this condition at earlier stage is important. There are different treatment options like pharmacological (NSAIDs, Anticonvulsants, Antidepressants, neuromodulators) and interventional techniques like Stellate ganglion block, Thoracic Sympathetic Ganglion block, Lumbar sympathetic block, Neurostimulation.
In this case report we present a case of 52 year old female post mastectomy and radiation therapy developing CRPS of left upper limb, which was diagnosed and managed successfully with diagnostic thoracic sympathetic ganglion block followed by therapeutic radiofrequency ablation.
Autologous Intrauterine Platelet Rich Plasma Versus G-CSF instillation for Improvement of Endometrial Growth and Vascularity in Recurrent in Vitro Fertilization Failure
Authors: Deo Asawari , Shrivastava Deepti , Chadha Arzoo 
Published: January 2022

Background: in vitro fertilization [IVF] is an expensive, cumbersome yet most successful treatment for infertility. Inspite of its success, at the most 40% of the procedure only result in good outcome. Often at times which can be very frustrating and disappointing journey for the couple as well as the clinicians who despite of strict adherence to treatment protocols fail to produce result, it is mostly attributed to implantation failure, which is mostly due to poor receptivity of the endometrium. Several treatments ranging from chinese acupuncture to hormones to endometrial injury all have been treat with not definitive treatment. Autologous platelet rich plasma (PRP) and G-CSF have come up to be exciting new therapy in that aspect. In neutrophilic granulocytes, platelet-rich plasma (PRP) has been shown to increase endometrial development and receptivity, whilst G-CSF has been shown to promote the growth of stem cells and progenitor cells. This study offers an intriguing perspective on the two medications in comparison.
Materials and Methods: It is a prospective ,cross-sectional, single blind study, conducted over a period of 6 months in 25 women who had failed to conceive after one or more embryo transfers with high-quality embryoswomen having a poor endometrial pattern, as defined by an endometrial thickness of less than 7mm despite conventional treatment with estradiol valerate (up to 12 mg/day), or suboptimal endometrial vascularity, defined as < zone 2 as determined by applebaum's criteria, success of which was measured in number of clinical pregnancies resulted.
Results: The mean PRP endometrial thickness was 5 mm which significantly increased to 7.34 mm post platelet rich plasma, against post-G-CSF endometrial thickness was 8.02 mm from 6.03mm pre infusion. Out of 10 cases who were infused with PRP,7 of them showed good vascularity (more than or equal to zone 3)out of 10 of those were given G-CSF,5 of them showed good vascularity. Number of clinical pregnancies resulted after instillation of PRP were 4 while 3 in case of G-CSF group.
Conclusion: It can be concluded that although both PRP and G-CSF are equally effective in increasing endometrial thickness but endometrial vascularity is better inproved with platelet rich plasma, clinical pregnancy rates were also better with PRP but being a small sample study it was not significant statistically.