bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wittgenstein y el psicoanálisis: aproximaciones desde el lenguaje, la ética y el sujeto
Authors: Jofré Daniel , Bilbao Alejandro 
Published: August 2022

El artículo busca indagar en el vínculo entre las elaboraciones de Wittgenstein y el psicoanálisis. La argumentación se detiene en las propuestas de Wittgenstein acerca de la imposibilidad autorreferencial del lenguaje, los actos éticos y el psicoanálisis. En este contexto, esboza una posible respuesta a las críticas que Wittgenstein dirigió al psicoanálisis, reflexionándolas desde tres nociones que son centrales en la obra de Jacques Lacan: causalidad, ficción y la idea de sujeto. Un segundo tiempo del artículo se propone pensar el vínculo entre ética y subjetividad, desde la temporalidad que introduce en el decir del humano la dinámica pulsional.
Implementation of Performance Accountability in Improving the Quality of Public Services
Authors: Sartono  , Suaib Eka , Amir Muhammad , Sukotjo Endro 
Published: August 2022

This study aims to describe how performance accountability improves the quality of public services.This research uses a descriptive qualitative approach with the research location at the Kendari City BAPENDA Office.The informants in this study were eleven people consisting of employees and service recipients.The data source in this study is to use primary and secondary data with data collection techniques carried out through observation, interviews, and documentation.Data analysis was carried out with data collection, data reduction, data display, and conclusions drawing.The results showed that the accountability of public services in BAPENDA Kendari City has been good.Service procedures are carried out with standard operating procedures (SOP), transparent service costs, and certainty of service time.However, the service has not utilized information and communication technology through the online tax payment program application.In addition, the quality of public services has not been fully optimal.One of the indicators shows that the service has not run as expected, such as the lack of employee friendliness towards taxpayers and convenience factor of service due to lack of facilities and infrastructure.
BOOKLET KONSELING TERHADAP PENINGKATAN PENGETAHUAN SELF CARE MANAGEMENT PADA PASIEN GAGAL GINJAL KRONIK (GGK) DENGAN HEMODIALISA
Authors: Barus Sadaukur Br , Zainaro M. Arifki 
Published: August 2022

Background: Counseling is an individual approach method to help patients deal with, overcome problems and make efforts that can be done on their own, especially in patients undergoing dialysis. Self care is one of the basic human abilities in meeting their needs to maintain life, health and well-being. Self care management in HD patients includes fluid restrictions, diet regulation, treatment and treatment of vascular access.Purpose: To analyze the effect of information booklets in self-management knowledge and self-care behavior among patient with patients with chronic renal failure undergoing dialysis at Dustira Hospital, Cimahi.Methods: Quasi experiment with pre test and post test control group design used in this study.Results: shows that the patient’s compliance on self care management is increase after counseling at intervention group with p value 0.000. family support confounding variable is the variable that affect patient’s compliance (with dialysis) on self care management. The recommendation for nurses is to continue the patient's health teaching using counseling, cooperate with the family to increase their compliance on self care management especially for the patient with dialysis.Keywords: Dialysis, Self Care Management, Booklet Pendahuluan: Konseling merupakan metode pendekatan individual untuk membantu pasien menghadapi, mengatasi masalah serta melakukan upaya yang dapat dilakukan dengan usaha sendiri khususnya pada pasien yang menjalani hemodialisa. Self care merupakan salah satu kemampuan dasar manusia dalam memenuhi kebutuhannya guna mempertahankan kehidupan, kesehatan dan kesejahteraan. Self care management pada pasien HD meliputi pembatasan cairan, pengaturan diet, pengobatan dan perawatan akses vaskuler.Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh booklet terhadap pengetahuan self care manajement pada pasien gagal ginjal kronik dengan hemodialisa di Rumah Sakit Dustira Kota Cimahi.Metode : Desain penelitian Quasi Eksperiment dengan Pre Test And Post Test With Control Group Desain, dengan jumlah sampel 56 responden yang dibagi menjadi kelompok intervensi dan kontrol.Hasil penelitian: menunjukan pengetahuan self care management pada pasien yang dengan hemodialisa meningkat setelah diberi konseling 10-15 menit pada kelompok intervensi dengan P value 0.000.Simpulan: untuk perawat pelaksana diruang hemodialisa dalam memberikan pendidikan kesehatan dengan metode konseling secara rutin dalam meningkatkan pengetahuan pasien menjalani terapi hemodialisa.
The potential of caproate (hexanoate) production using Clostridium kluyveri syntrophic cocultures with Clostridium acetobutylicum or Clostridium saccharolyticum
Authors: Otten Jonathan K. , Zou Yin , Papoutsakis Eleftherios T. 
Published: August 2022

Caproate (hexanoate) and other medium-chain fatty acids are valuable platform chemicals produced by processes utilizing petroleum or plant oil. Clostridium kluyveri, growing on short chain alcohols (notably ethanol) and carboxylic acids (such as acetate) is noted for its ability to perform chain elongation to produce 4- to 8-carbon carboxylates. C. kluyveri has been studied in monoculture and coculture conditions, which lead to relatively modest carboxylate titers after long fermentation times. To assess the biosynthetic potential of C. kluyveri for caproate production from sugars through coculture fermentations, in the absence of monoculture data in the literature suitable for our coculture experiments, we first explored C. kluyveri monocultures. Some monocultures achieved caproate titers of 150 to over 200 mM in 40–50 h with a production rate of 7.9 mM/h. Based on that data, we then explored two novel, syntrophic coculture partners for producing caproate from sugars: Clostridium acetobutylicum and Clostridium saccharolyticum. Neither species has been cocultured with C. kluyveri before, and both demonstrate promising results. Our experiments of C. kluyveri monocultures and C. kluyveri—C. saccharolyticum cocultures demonstrate exceptionally high caproate titers (145–200 mM), fast production rates (3.25–8.1 mM/h), and short fermentation times (18–45 h). These results represent the most caproate produced by a C. kluyveri coculture in the shortest known fermentation time. We also explored the possibility of heterologous cell fusion between the coculture pairs similar to the results seen previously in our group with C. acetobutylicum and Clostridium ljungdahlii. Fusion events were observed only in the C. acetobutylicum—C. kluyveri coculture pair, and we offer an explanation for the lack of fusion between C. saccharolyticum and C. kluyveri. This work supports the promise of coculture biotechnology for sustainable production of caproate and other platform chemicals.
The short-term efficacy of adventitial inversion with graft eversion anastomosis for the reconstruction of the aortic sinus in the root treatment of aortic dissection
Authors: Gao Feng , Shi Zepeng , He Xuezhi , Gao Yang , Zhuang Xijing , Shi Lei , Wang Wenjun , Liu Wei 
Published: August 2022

BackgroundThe surgical approaches for a mildly affected aortic sinus (AS) are varied and controversial. Here, the AS was reconstructed using the extended adventitial inversion with graft eversion anastomosis technique before its perioperative and short-term efficacy was compared with that of the vascular grafts that wrap the aortic wall and the right atrial shunt technique, providing a new basis for surgical management strategies.MethodA total of 101 patients with mildly affected AS were enrolled in the clinical trial. The extended adventitial inversion suture and the graft eversion anastomosis technique was performed in group A. Aorta wrapping and the right atrial shunt technique were performed in group B. The primary endpoints were reoperation-related events and fatal events related to the aorta, while the secondary endpoints were the duration of surgery and structural changes in the aortic root. Cardiac ultrasound and aortic computed tomography angiography examinations were performed before surgery, 2 weeks after surgery, and 1 year after surgery.ResultsCompared to group B (n = 56), group A (n = 36) had a significantly shorter duration of surgery (the time from skin incision to skin closure) and a reduced time from shutdown to skin closure (P &lt; 0.05). Cardiovascular ultrasound examinations performed at follow-up 12 months after surgery and 2 weeks after surgery revealed a significant increase in the diameter of the aortic sinotubular junction (STJ) of group B (n = 50) (P &lt; 0.05). The extended adventitial inversion suture and the graft eversion anastomosis technique (n = 33) performed better than Aorta wrapping and the right atrial shunt technique in terms of persistence of the false lumen closure effect, anastomotic leakage, and reduction in aortic valve (P &lt; 0.05), and there was a significant difference between the two groups in terms of the incidence of events related to reoperation (P &lt; 0.05).ConclusionCompared with the aorta wrapping and the right atrial shunt technique, the extended adventitial inversion suture and the graft eversion anastomosis technique allow shortening of the operation time and preventing near-term dilation of the STJ, with improved safety and an improved short-term surgical effect.
Comparison between endovascular aneurysm repair-selected and endovascular aneurysm repair-only strategies for the management of ruptured abdominal aortic aneurysms: An 11-year experience at a Chinese tertiary hospital
Authors: Fang Gang , Yue Jianing , Shuai Tao , Yuan Tong , Ren Bichen , Fang Yuan , Pan Tianyue , Liu Zhenjie , Dong Zhihui , Fu Weiguo 
Published: August 2022

ObjectivesThe aim of this study was to review our management experience of ruptured abdominal aortic aneurysms (RAAAs) using an endovascular aneurysm repair (EVAR)-only strategy, and discuss the feasibility of this strategy.Materials and methodsA retrospective analysis of clinical data was performed in patients with RAAAs from January 2009 to October 2020. Our strategy toward operative treatment for RAAAs evolved from an EVAR-selected (from January 2009 to April 2014) to an EVAR-only (from May 2014 to October 2020) strategy. Baseline characteristics, thirty-day mortality, perioperative complications, and long-term outcomes of patients were compared between the two periods.ResultsA total of 93 patients undergoing emergent RAAA repair were eventually included. The overall operation rate in RAAAs at our centre was 70.5% (93/132). In the EVAR-only period, all 53 patients underwent ruptured endovascular aneurysm repair (rEVAR). However, only 47.5% (19/40) of patients in the EVAR-selected period underwent rEVAR, and the remaining 21 patients underwent emergent open surgery. Thirty-day mortality in the EVAR-only group was 22.6% (12/53) compared with 25.0% (10/40) for the EVAR-selected group (P= 0.79). Systolic blood pressure ≤70 mmHg [adjusted odds ratio (OR) 4.99, 95% confidence interval (CI), 1.13–22.08,P= 0.03] and abdominal compartment syndrome (adjusted OR 3.72, 95% CI, 1.12–12.32,P= 0.03) were identified as independent risk factors responsible for 30-day mortality. After 5 years, 47.5% (95% CI, 32.0–63.0%) of patients in the EVAR-selected group were still alive versus 49.1% (95% CI, 32.3–65.9%) of patients in the EVAR-only group (P= 0.29).ConclusionThe EVAR-only strategy has allowed rEVAR to be used in nearly all the RAAAs with similar mortality comparing with the EVAR-selected strategy. Due to the avoidance of operative modality selection, the EVAR-only strategy was associated with a more simplified algorithm, less influence on haemodynamics, and a shorter operation and recovery time.
CYP2C19 polymorphisms and lipoproteins associated with clopidogrel resistance in children with Kawasaki disease in China: A prospective study
Authors: Zhang Mingming , Meng Li , Chen Yeshi , Li Xiaohui , Shi Lin 
Published: August 2022

BackgroundCYP2C19 genetic variation and clinical factors have been proved to be related with clopidogrel resistance (CR) in adults, while the presence of CR in children with Kawasaki disease (KD) was seldom reported. Our objective was to evaluate KD patients’ response to clopidogrel treatment and determine whether CYP2C19 gene polymorphisms and laboratory indicators are associated with CR in this population.MethodsThis was a prospective and single-center study. We recruited children with KD hospitalized in the cardiology department at the Children’s Hospital Capital Institute of Pediatrics between January 2019 and October 2021, and the distribution of the CYP2C19 gene polymorphisms was assessed. According to the light transmission aggregometry (LTA) test results, KD patients who were treated with clopidogrel were divided into CR group and non-CR (NCR) group. We also analyzed the influence of CYP2C19 gene polymorphisms and laboratory indicators on CR in children with KD.Results(1) A total of 346 children with KD were evaluated for the genotypic and phenotypic distributions of CYP2C19. Loss-of-function (LOF) mutated allele was included in 56.9% of CYP2C19 genotypes, and their corresponding phenotypes were intermediate metabolizers (46.2%) and poor metabolizers (10.7%). (2) The incidence of CR in this study population was 31.4%. The multivariate logistic regression showed that carrying CYP2C19 LOF allele (OR, 3.922; 95%CI, 1.504–10.282; P = 0.005) and high levels of low-density lipoprotein (OR, 1.675; 95%CI, 1.069–2.623; P = 0.024) were independent risk factor for CR, while low levels of high-density lipoprotein (OR, 0.120; 95%CI, 0.020, 0.734; P = 0.022) was an independent protective factor for CR. The area under the receiver operator characteristic curve of the multivariate logistic regression model (including high-density lipoprotein, low-density lipoprotein, and CYP2C19 LOF allele carriers) for predicting CR was 0.769 (95% CI, 0.674–0.863; P &lt; 0.001). The sensitivity and specificity were 70.3 and 74.0%, respectively.ConclusionCarrying CYP2C19 LOF allele, low levels of high-density lipoprotein, and high levels of low-density lipoprotein were independent risk factors for CR in children with KD in China. This may benefit pediatricians in choosing appropriate individualized antiplatelet therapy.
A case report of long-term successful stereotactic arrhythmia radioablation in a cardiac contractility modulation device carrier with giant left atrium, including a detailed dosimetric analysis
Authors: Levis Mario , Dusi Veronica , Magnano Massimo , Cerrato Marzia , Gallio Elena , Depaoli Alessandro , Ferraris Federico , De Ferrari Gaetano Maria , Ricardi Umberto , Anselmino Matteo 
Published: August 2022

IntroductionCatheter ablation (CA) is the current standard of care for patients suffering drug-refractory monomorphic ventricular tachycardias (MMVTs). Yet, despite significant technological improvements, recurrences remain common, leading to increased morbidity and mortality. Stereotactic arrhythmia radioablation (STAR) is increasingly being adopted to overcome the limitations of conventional CA, but its safety and efficacy are still under evaluation.Case presentationWe hereby present the case of a 73-year-old patient implanted with a mitral valve prosthesis, a cardiac resynchronization therapy-defibrillator, and a cardiac contractility modulation device, who was successfully treated with STAR for recurrent drug and CA-resistant MMVT in the setting of advanced heart failure and a giant left atrium. We report a 2-year follow-up and a detailed dosimetric analysis.ConclusionOur case report supports the early as well as the long-term efficacy of 25 Gy single-session STAR. Despite the concomitant severe heart failure, with an overall heart minus planned target volume mean dosage below 5 Gy, no major detrimental cardiac side effects were detected. To the best of our knowledge, our dosimetric analysis is the most accurate reported so far in the setting of STAR, particularly for what concerns cardiac substructures and coronary arteries. A shared dosimetric planning among centers performing STAR will be crucial in the next future to fully disclose its safety profile.
One-hour plasma glucose as a long-term predictor of cardiovascular events and all-cause mortality in a Chinese older male population without diabetes: A 20-year retrospective and prospective study
Authors: Rong Lingjun , Cheng Xiaoling , Yang Zaigang , Gong Yanping , Li Chunlin , Yan Shuangtong , Sun Banruo 
Published: August 2022

IntroductionElevated one-hour plasma glucose (1 h-PG) during oral glucose tolerance test predicts the development of type 2 diabetes mellitus and its complications. However, to date, there have been no studies investigating the predictive values of 1 h-PG for the risk of cardiovascular diseases (CVDs) and all-cause mortality in the elderly population in China. This study aimed to evaluate and compare the effectiveness of 1 h-PG and two-hour plasma glucose (2 h-PG) to predict the risk of CVD and all-cause mortality in the Chinese elderly population.Materials and methodsThis retrospective and prospective cohort study was conducted using data obtained from the Chinese People’s Liberation Army General Hospital. All the non-diabetic elderly participants, who had plasma glucose measured at 0, 1, and 2 h during an OGTT (75 g glucose), were followed for 20 years. The primary outcomes were all-cause mortality, myocardial infarction, unstable angina, and stroke. Multivariate-adjusted Cox proportional hazard regression models were performed to examine the association between risk factors and outcomes and to estimate the risk of CVD and all-cause mortality based on 1 h-PG levels.ResultsA total of 862 non-diabetic male individuals were included. The median age was 74.0 (25th–75th percentile: 68.0–79.0) years. There were 480 CVD events and 191 deaths during 15,527 person-years of follow-up. The adjusted hazard ratio (HR) of 1 h-PG as a continuous variable was 1.097 (95% CI 1.027–1.172; P = 0.006) for CVD events and 1.196 (95% CI 1.115–1.281; P &lt; 0.001) for higher risk of mortality. When compared with the lowest 1 h-PG tertile, the other tertiles were associated with CVD events (HR 1.464, 95% CI 1.031–2.080; P = 0.033 and HR 1.538, 95% CI 1.092–2.166; P = 0.014, for tertile 2 and tertile 3 compared with tertile 1, respectively), and the highest 1 h-PG tertile had a significantly higher risk of mortality (HR 2.384, 95% CI 1.631–3.485; P &lt; 0.001) after full adjustment. Compared with 1 h-PG, 2 h-PG had similar abilities to predict all-cause mortality. However, 2 h-PG was less closely associated with CVD when examined in the fully adjusted model, neither as a continuous variable nor as a categorical variable. Conversely, 1 h-PG remained an independent predictor of CVD and all-cause mortality after adjusting for various traditional risk factors.ConclusionPatients with higher 1 h-PG had a significantly increased risk of CVD and all-cause mortality regardless of prediabetes status or development of diabetes at follow-up. The 1 h-PG level might be a better predictor of cardiovascular risk than the 2 h-PG level for the Chinese elderly population.
Optimization of the elimination of antibiotics by Lemna gibba and Azolla filiculoides using response surface methodology (RSM)
Authors: Maldonado Ingrid , Vega Quispe Anyela Pierina , Merma Chacca Donald , Zirena Vilca Franz 
Published: August 2022

Antibiotic residues have been found in environmental samples, such as water, soil, and even food, and usually come from wastewater, presenting environmental and human health risks. This study aimed to improve the elimination of the antibiotics tetracycline (Tet) and chloramphenicol (Chlor) by modifying three factors: contact time (3–7 days), plant biomass (10–14 g), and antibiotic concentration (5–15 mg/L Tet and 10–20 mg/L Chlor). An approach that optimizes time and resources, response surface methodology (RSM), was applied with a Box–Behnken design (BBD) to two plant species (L. gibba and A. filiculoides), i.e., one experimental design was used for each species. Antibiotic residues in water and plant samples were analyzed by liquid chromatography. The optimal conditions for Tet removal were 6.04 d, 11.4 g, and 13.4 mg/L with Lemna and 6.3 d, 11.9 g, and 14.7 mg/L with Azolla; the optimal conditions for Chlor removal were 7.8 d, 13.6 g, and 10.2 mg/L with Lemna and 4.6 d, 12.3 g, and 8.7 mg/L with Azolla. The results showed that the removal efficiency of antibiotics increased depending on the species used, reaching a maximum of up to 100%. Tet was better removed than Chlor, reaching maximum removal values of 100% and 84% with Azolla and Lemna, respectively. Chlor removal reached 70% and 64% with Azolla and Lemna, respectively. The mean bioconcentration factors (BCFs) of Tet were 2.9% in Lemna and 4.9% in Azolla, and the BCFs for Chlor were 38.1% in Lemna and 37.8% in Azolla. Thus, in general, better results were obtained with Azolla. In summary, the results demonstrate that this design and the selected plants contribute to the removal of antibiotics, presenting a sustainable and recommended alternative for the treatment of wastewater contaminated with antibiotic residues.
Ecological networks and corridors development in urban areas: An example of Tabriz, Iran
Authors: Mahmoudzadeh Hassan , Masoudi Hassan , Jafari Firouz , Khorshiddoost Ali Mohammad , Abedini Asghar , Mosavi Amir 
Published: August 2022

Landscape fragmentation and the elimination of urban green spaces are the results of human activities which put significant pressure on urban sustainability. The planning and developing of urban ecological networks and corridors as an effective approach is a response to rapid urbanization and fragmentation of natural areas. The Tabriz metropolitan as the fourth-largest city in Iran was selected as a case study that has grown rapidly over the past few decades. This study presents a practical approach and framework for assessing and enhancing ecological connectivity of landscape. The framework was developed based on the landscape metrics, graph theory, least-cost modeling, and geographic information system tools during three different periods (1984-2000-2020). The results using the values of landscape metrics such as CA, Edge Distance, Mean Patch Size, Mean Shape Index, large patch index, NP, Landscape shape index, and COHESION indicate that the urban landscape of Tabriz has been more fragmented over the past 3 decades and has lost its connectivity. To reduce the effects of fragmentation and enhance landscape connectivity in study area, we proposed a network of ecological corridors that passes through the core ecological patches. Our results also indicate that the core patches and the least-cost created corridors are mainly located in the suburbs of Tabriz and the central part of the city cannot be suitable for ecological development. Therefore, using the above-mentioned methods could be an effective approach to develop ecological networks and improve landscape connectivity that can encourage urban planners and managers to protect and develop green networks.