bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of medical tests use with care continuity in primary care service: evidence from the Department of Veterans Affairs
Authors: Akunna Adebola A , Ahuja Vishal , Halm Ethan A , Alvarez Carlos A 
Published: September 2022

AbstractBackgroundContinuity of care (CoC) is an important component of health care delivery that can have cost implications and improve patient outcomes. We analysed data obtained from the Department of Veterans Affairs to examine the relationship between CoC and use of image-oriented diagnostic tests in patients with comorbid chronic conditions.MethodsA longitudinal, retrospective cohort study involving participants ≥18 years old, with comorbid diabetes and chronic kidney disease. We used a multivariate linear regression model to test whether greater care continuity, measured using a care continuity index (CCI), is associated with less frequent use of diagnostic tests.ResultsTotal of 267,442 patients and 8,142,036 tests were included. Of the diagnostic tests we chose to evaluate, the 4 most frequently ordered tests were X-ray (45.6%), electrocardiogram (EKG, 16.8%), computerized tomography (CT, 13.4%), and magnetic resonance imaging (MRI, 3.4%). Overall, greater CCI was associated with fewer use of tests (P &lt; 0.001). A 1 standard deviation (SD, 0.27) increase in CCI was associated with 4.2% decrease (P &lt; 0.001) in number of tests. But a mixed pattern existed. For X-ray and EKG, greater continuity was associated with less testing, 6.2% (P &lt; 0.001) and 3.3% (P &lt; 0.05) reductions, respectively. Whereas, for CT and MRI, greater continuity was associated with more testing, 2.3% (P &lt; 0.001) and 1.4% increases (P &lt; 0.01), respectively.ConclusionOverall, greater CoC was associated with fewer use of tests, representing a greater presumed efficiency of care. This has implications for designing health care delivery.
Chromosome-level Genome of the Muskrat (Ondatra zibethicus)
Authors: Li Haimeng , Shi Minhui , Wang Qing , Xia Tian , Sahu Sunil Kumar , Zhang Yu , Wang Jiangang , Li Tianfeng , Ma Yue , Liu Tianlu , Liu Huan , Lan Tianming , Bai Suying 
Published: September 2022

Abstract
The muskrat (Ondatra zibethicus) is a semi-aquatic rodent species with ecological, economic, and medicinal importance. Here, we present an improved genome assembly, which is the first high-quality chromosome-level genome of the muskrat with high completeness and contiguity assembled using single-tube long fragment read, BGISEQ, and Hi-C sequencing technologies. The genome size of the final assembly was 2.63 Gb with 27 pseudochromosomes. The length of scaffold N50 reached 80.25 Mb with a Benchmarking Universal Single-Copy Ortholog score of 91.3%. We identified a 66.98 Mb X chromosome and a 1.14-Mb Y-linked genome region, and these sex-linked regions were validated by resequencing 32 extra male individuals. We predicted 19,396 protein-coding genes, among which 19,395 (99.99%) were functionally annotated. The expanded gene families in the muskrat genome were found to be enriched in several organic synthesis- and metabolism-related Gene Ontology terms, suggesting the likely genomic basis for the production and secretion of musk. This chromosome-level genome represents a valuable resource for improving our understanding of muskrat ecology and musk secretion.
Structural properties of the Southern San Andreas fault zone in northern Coachella Valley from magnetotelluric imaging
Authors: Share Pieter-Ewald , Peacock Jared R , Constable Steven , Vernon Frank L , Wang Shunguo 
Published: September 2022

SUMMARYThe Southern San Andreas fault (SSAF) poses one of the largest seismic risks in California. Yet, there is much ambiguity regarding its deeper structural properties around Coachella Valley, in large part due to the relative paucity of everyday seismicity. Here, we image a multistranded section of the SSAF using a non-seismic method, namely magnetotelluric (MT) soundings, to help inform depth-dependent fault zone geometry, fluid content and porosity. The acquired MT data and resultant inversion models highlight a conductive column encompassing the SSAF zone that includes a 2–3 km wide vertical to steeply northeast dipping conductor down to ∼4 km depth (maximum of ∼1 Ω·m at 2 km depth) and another prominent conductor in the ductile crust (∼1 Ω·m at 12 km depth and slightly southwest of the surface SSAF). We estimate porosities of 18–44 per cent for the conductive uppermost 500 m, a 10–15 per cent porosity at 2 km depth and that small amounts (0.1–3 per cent) of interconnected hypersaline fluids produce the deeper conductor. Located northeast of this conductive region is mostly resistive crust indicating dry crystalline rock that extends down to ∼20 km in places. Most of the local seismicity is associated with this resistive region. Located farther northeast still is a conductive region at &gt;13 km depth and separate from the one to the southwest. The imaged anomalies permit two interpretations. The SSAF zone is vertical to steeply northeast dipping in the upper crust and (1) is near vertical at greater depth creating mostly an impermeable barrier for northeast fluid migration or (2) continues to dip northeast but is relatively dry and resistive up to ∼13 km depth where it manifests as a secondary deep ductile crustal conductor. Taken together with existing knowledge, the first interpretation is more likely but more MT investigations are required.
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials
Authors: Wicht Kathryn J , Small-Saunders Jennifer L , Hagenah Laura M , Mok Sachel , Fidock David A 
Published: September 2022

Abstract

Background
Additional therapeutic strategies could benefit efforts to reverse the recent increase in malaria cases in sub-Saharan Africa, which mostly affects young children. A primary candidate is dihydroartemisinin + piperaquine (DHA + PPQ), which is effective for uncomplicated malaria treatment, seasonal malaria chemoprevention, and intermittent preventive treatment. In Southeast Asia, Plasmodium falciparum parasites acquired PPQ resistance, mediated primarily by mutations in the P falciparum chloroquine resistance transporter PfCRT. The recent emergence in Africa of DHA-resistant parasites creates an imperative to assess whether PPQ resistance could emerge in African parasites with distinct PfCRT isoforms.

Methods
We edited 2 PfCRT mutations known to mediate high-grade PPQ resistance in Southeast Asia into GB4 parasites from Gabon. Gene-edited clones were profiled in antimalarial concentration-response and fitness assays.

Results
The PfCRT F145I mutation mediated moderate PPQ resistance in GB4 parasites but with a substantial fitness cost. No resistance was observed with the PfCRT G353V mutant. Both edited clones became significantly more susceptible to amodiaquine, chloroquine, and quinine.

Conclusions
A single PfCRT mutation can mediate PPQ resistance in GB4 parasites, but with a growth defect that may preclude its spread without further genetic adaptations. Our findings support regional use of drug combinations that exert opposing selective pressures on PfCRT.
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy
Authors: Cambou Mary C , Liu Christine M , Mok Thalia , Fajardo-Martinez Viviana , Paiola Sophia G , Ibarrondo Francisco J , Kerin Tara , Fuller Trevon , Tobin Nicole H , Garcia Gustavo , Bhattacharya Debika , Aldrovandi Grace M , Arumugaswami Vaithilingaraja , Foo Suan-Sin , Jung Jae U , Vasconcelos Zilton , Brasil Patricia , Brendolin Michelle , Yang Otto O , Rao Rashmi , Nielsen-Saines Karin 
Published: September 2022

AbstractBackgroundThere are limited data on how coronavirus disease 2019 (COVID-19) severity, timing of infection, and subsequent vaccination impact transplacental transfer and persistence of maternal and infant antibodies.MethodsIn a longitudinal cohort of pregnant women with polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, maternal/infant sera were collected at enrollment, delivery/birth, and 6 months. Anti-SARS-CoV-2 spike immunoglobulin (Ig)G, IgM, and IgA were measured by enzyme-linked immunosorbent assay.ResultsTwo-hundred fifty-six pregnant women and 135 infants were enrolled; 148 maternal and 122 neonatal specimens were collected at delivery/birth; 45 maternal and 48 infant specimens were collected at 6 months. Sixty-eight percent of women produced all anti-SARS-CoV-2 isotypes at delivery (IgG, IgM, IgA); 96% had at least 1 isotype. Symptomatic disease and vaccination before delivery were associated with higher maternal IgG at labor and delivery. Detectable IgG in infants dropped from 78% at birth to 52% at 6 months. In the multivariate analysis evaluating factors associated with detectable IgG in infants at delivery, significant predictors were 3rd trimester infection (odds ratio [OR] = 4.0), mild/moderate disease (OR = 4.8), severe/critical disease (OR = 6.3), and maternal vaccination before delivery (OR = 18.8). No factors were significant in the multivariate analysis at 6 months postpartum.ConclusionsVaccination in pregnancy post-COVID-19 recovery is a strategy for boosting antibodies in mother-infant dyads.
A Theoretical Framework for Law and Macro-Finance
Authors: Borowicz M Konrad 
Published: September 2022

Abstract
This article considers the effects of legal protections of creditors within the macro-financial theory of leverage cycles developed by John Geanakoplos. The theory posits that leverage is procyclical. I propose a theoretical framework, ‘Law and Macro-Finance’, comprising two main clams: (1) the strength of legal protections of creditors has an impact on the quantum of debt creditors are willing to underwrite not just the interest rate on that debt and (2) that quantum varies across the cycle in a procyclical fashion. In a boom, when asset prices are higher, leverage decreases, creating incentives for creditors to underwrite additional leverage secured on those assets without increasing the interest rate. The stronger the legal protections of creditors, the stronger the incentives to underwrite additional leverage based solely on the increasing value of the collateral. By creating such incentives, strong legal protections of creditors, associated with claims designated in the law as ‘bankruptcy remote’, will accelerate the boom and increase the vulnerability of the economy to shocks. On the normative side, this article proposes a countercyclical design of strong legal protections of creditors. The design makes the availability of such protections, typically achieved by reliance on the legal doctrine of ‘true sales’, conditioned on the adequacy of the price paid in the transaction. The adequacy, in turn, is determined in reference to the applicable schedule of collateral haircuts determined by the central bank.
Spatial and phase resolution in electron microscopy
Authors: Ishikawa Ryo , Morishita Shigeyuki , Tanigaki Toshiaki , Shibata Naoya , Ikuhara Yuichi 
Published: September 2022

AbstractWith the invention of the aberration corrector in electron optics, the spatial resolution in electron microscopy has progressively improved and has now reached the sub-50-pm regime, and atomic-resolution electron microscopy has become a versatile tool for investigating the atomic structures in materials and devices. Furthermore, the phase resolution in electron microscopy also exhibits outstanding progress, and it has become possible to visualize electromagnetic fields at atomic dimensions, which strongly contributes to understanding the physical and chemical properties of materials. The electron microscopy society has grown with the improvements in spatial and phase resolutions, and hence, we must continuously develop new hardware, software and methodologies to boost these resolutions. Here, we review the historical progress of spatial and phase resolutions in electron microscopy, where we clarify the definition of these resolutions. We also discuss the future targets in electron microscopy.
Characterization of Cervus timorensis velvet antler and its effect on biofilm formation of Candida species
Authors: Mohd Badri Puteri Elysa Alia , Rismayuddin Nurul Alia Risma , Kenali Norzaiti Mohd , Darnis Deny Susanti , Arzmi Mohd Hafiz 
Published: September 2022

Abstract
Oral biofilms comprise extracellular polysaccharides and polymicrobial microorganisms. The objectives of the study were to characterize the deer velvet antler (DVA) compounds and their effect on Candida species biofilm formation with the hypothesis that DVA inhibits the biofilm of Candida spp. Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (LC-QTOF-MS) was conducted to characterize the DVA compounds. To study the effect of DVA on biofilm, Candida albicans ATCC MYA-4901 (ALT5), AIDS isolate (ALC2), oral cancer isolate (ALC3), C. dubliniensis ATCC MYA-2975, C. glabrata ATCC 90030, C. krusei 14 243, C. lusitaniae ATCC 34449, C. parapsilosis ATCC 22019, and C. tropicalis ATCC 13803 were inoculated with DVA in separate wells of a 96-well plate containing RPMI-1640 followed by 72 h incubation. A total of 45 compounds were detected in the DVA extract. C. lusitaniae exhibited a higher percentage of biofilm biomass reduction when treated with DVA extract (66.10% ± 5.33), followed by ALC3 (44.12% ± 6.24). However, C. glabrata, C. krusei, and C. parapsilosis showed no reduction in biofilm biomass after being treated with DVA extract. Most Candida strains also exhibited decreased total cell count when treated with DVA extract, except for ALC3 and C. krusei. ALT5 had the lowest total cell count (0.17 × 105 cells/ml) when cultured with DVA extract. In conclusion, DVA extract inhibits Candida spp. biofilm formation except for C. glabrata, C. krusei, and C. parapsilosis.
A 3.8 yr optical quasi-periodic oscillations in blue quasar SDSS J132144+033055 through combined light curves from CSS and ZTF
Authors: Zhang XueGuang 
Published: September 2022

ABSTRACT
In the manuscript, a 3.8 yr optical quasi-periodic oscillations (QPOs) is reported in blue quasar SDSS J132144+033055 (= SDSS J1321) at z = 0.269, based on 16.3yr-long light curve from both CSS and ZTF directly described by a sinusoidal function. The 3.8 yr QPOs can be confirmed through the Generalized Lomb–Scargle periodogram with confidence level higher than 5σ, through properties of the phase-folded light curve and the WWZ technique. Moreover, the collected Pan-STARRS light curves well follow the sinusoidal function described best fitting results to the Catalina Sky Survey (CSS) and Catalina Sky Survey (ZTF) light curves. The optical QPOs strongly indicate a central binary black hole (BBH) system in SDSS J1321, with expected space separation smaller than 0.018 pc, through the estimated upper limit of total BH mass 3.3 × 109 M⊙ through the correlation between BH mass and continuum luminosity. Meanwhile, we check disc precession applied to explain the optical QPOs. However, under the disc precession assumption, the determined optical emission regions from central BH have sizes about 37RG similar as the sizes 35RG of the expected NUV emission regions through the correlation between disc size and BH mass, indicating the disc precession is not preferred. And due to undetected radio emissions, jet precession can be ruled out. Furthermore, only 0.1 per cent probability can determined as the QPOs mis-detected through CAR process randomly created light curves related to intrinsic AGN activities, re-confirming the optical QPOs with significance level higher than 3σ. Therefore, combining long-term light curves from CSS and ZTF can lead to more QPOs candidates in the near future.
Fine’s Monster Objection Defanged
Authors: Costa Damiano , Cecconi Alessandro , Calosi Claudio 
Published: September 2022

AbstractThe Monster Objection has often been considered one of the main reasons to explore non-standard mereological views, such as hylomorphism. Still, it has been rarely discussed and then only in a cursory fashion. This paper fills this gap by offering the first thorough assessment of the objection. It argues that different metaphysical stances, such as presentism and three- and four-dimensionalism, provide different ways of undermining the objection.
Original Research: ‘It Would Be Nice to Think We Could Have a Voice’: Exploring RN Involvement in Hospital Staffing Policymaking
Authors: Bartmess Marissa P. , Myers Carole R. , Thomas Sandra P. 
Published: September 2022

Background:
Hospitalized patient and nursing outcomes improve when nurses are involved in decision-making practices through shared governance structures. Yet there has been little research investigating how staff nurses are involved in hospital staffing policymaking and how they perceive this process.

Purpose:
The study's primary aims were to increase understanding of staff nurses' perceptions of factors that hinder or support nurse involvement in hospital nurse staffing policymaking and to learn more about how nurses are, or would like to be, so involved. We also collected nurses' work environment and demographic information to further inform our understanding.

Methods:
This study used a qualitative descriptive approach. Using QuestionPro software, we solicited open-ended responses to semistructured questions to explore the topics of interest. The online form was distributed via social media. Results were analyzed using conventional content analysis. Multiple-choice questions related to demographics and nurse work environments were also included, and these results were analyzed using descriptive statistics.

Results:
Thirty-two staff nurses completed the online form between April 5 and May 24, 2021. Identified themes include “We aren't asked”: structural barriers to staff nurse involvement; “No one cares”: workplace culture barriers to staff nurse involvement; and “‘They’ versus ‘we’”: lack of power sharing for staffing decision-making. Participants described feeling powerless with regard to, and having little to no involvement in, hospital staffing policymaking. Yet they also expressed their desire to be engaged in this process and offered suggestions for how nurse involvement in such policymaking could be improved.

Conclusion:
Our findings provide crucial insight into how organizations can address existing structural barriers to nurse involvement, offer more equitable opportunities for nurse involvement, foster more inclusive workplace cultures, and recognize the value of nurse input and autonomy regarding staffing decisions.
The Impaired Nurse
Authors: Salani Deborah , Goldin Deana , Valdes Beatriz , McKay Mary 
Published: September 2022

ABSTRACT:
Substance use disorders (SUDs) do not discriminate. Anyone can be affected regardless of age, sex, ethnicity, socioeconomic status, or profession. Nurses with SUDs present serious risks to both their patients and the nursing profession. Frontline nurses' responsibility to provide patients with safe, high-quality care may be too great a challenge for those with SUDs, resulting in adverse consequences. Early recognition and treatment of nurses with SUDs promotes patient safety and retention in the profession. For this reason, all nurses and other health care professionals should be able to recognize behaviors associated with SUDs and should be familiar with the available treatment modalities.
Compounding of Low-Concentration Atropine for Myopia Control
Authors: Richdale Kathryn , Tomiyama Erin S. , Novack Gary D. , Bullimore Mark A. 
Published: September 2022

Objectives:
Low-concentration atropine is commonly prescribed to slow myopia progression in children but is not Food and Drug Administration–approved for that indication and is only available in the United States from compounding pharmacies. The purpose of this study was to ascertain its reported compounding and labeling in the United States.

Methods:
US compounding pharmacies were identified through a survey of eye doctors, social media, conferences, and web search. Twenty-eight pharmacies were identified and contacted through telephone and asked a standard set of questions about their methods to compound and label low-concentration atropine.

Results:
Twenty-six pharmacies across 19 states provided responses, with 21 answering all nine items (81%) and a mean of 8.7 of nine responses. The most frequently reported bottle size was 5 mL (interquartile range [IQR]: 3.5–10). For storage, 10 pharmacies (38%) recommended refrigeration and 16 (62%) stated room temperature was sufficient. The median beyond-use date provided was 65 days (IQR: 45–158). For preparation, 12 pharmacies (50%) used commercially available 1% solution, 9 (38%) used powdered atropine, 2 (8%) used both, and 1 (4%) stated their approach was proprietary. For the added excipients, 11 (42%) used artificial tears only, 6 (23%) added 0.9% saline only, 7 (27%) used more than one ingredient, and 2 (8%) were proprietary. Only two pharmacies mentioned adding boric acid and two mentioned “pH-adjusted” saline.

Conclusions:
There were a wide variety of formulation methods in the United States, which may affect atropine stability and potency. Similarly, there are a wide variety of storage and beyond-use recommendations. Further research is needed to assess how these variations may affect the efficacy and safety of low-concentration atropine and of myopia control.
High Morbidity of Mycobacterial Infections Following Cosmetic Surgery Tourism
Authors: Massand Sameer , Butterfield James A. , Lee Charles C. , Ingraham John M. , Potochny John D. 
Published: September 2022

Background
Medical tourism is an increasingly popular practice among cosmetic surgery patients. These procedures place patients at risk of infection by rapidly growing Mycobacterium. Rapidly growing Mycobacterium (RGM) is a relatively rare infection within developed nations. Management options vary, although all pose significant morbidity to patients. We present 2 cases treated at our institution and a comprehensive literature review of RGM infection in patients who have undergone cosmetic surgery in developing nations, analyzing its associated morbidity.

Methods
This is a review of institutional records for patients with RGM infections after cosmetic surgery tourism was performed. A comprehensive literature search was conducted to identify reports of similar cases. Individual treatment courses were reviewed and descriptive statistics performed for management and associated morbidities.

Results
Two patients underwent abdominoplasty in a developing nation and later presented to our institution with mycobacterial infection. They underwent a combined 7 procedures, received a combined 3 years of antibiotic therapy, and accounted for 1 line-associated deep venous thrombosis and line-associated bacteremia. Thirty-five similar cases were identified by literature review. Patients underwent an average of 2.4 surgical procedures and received antibiotics for an average of 8.7 months. At least half of the patients (51%) required medication adjustment due to adverse effects or expense. Further morbidities encountered were financial hardship, psychological distress, and scar hypersensitivity.

Conclusion
Patients who undergo cosmetic surgery as medical tourists are placed at risk of infection by rapidly growing mycobacterial species. Management is highly morbid, and they are often left with extensive surgical scarring and unanticipated additional out-of-pocket expense.