bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of laser-assisted cart positioning significantly reduces the docking time of multimodular robotic systems
Authors: Baunacke Martin , Hirtsiefer Christopher , Herout Roman , Mehralivand Sherif , Oelkers Susanne , Kaske Oliver , Franz Claudia , Thomas Christian 
Published: January 2025

AbstractThe Hugo RAS system is characterized by its multimodular design, which leads to an increased docking effort. Exact data for docking time and the learning curve is missing. We describe for the first time the use of a laser-guided cart positioning to reduce the docking time. In this prospective monocentric study, the docking time was evalutated for a consecutive series of pelvic surgeries with the Hugo RAS system. In a subgroup, a cross-line laser was adapted at the cart for positioning using fix points at the ceiling. The medical personnel were classified as “inexperienced” with ≤ 5 consecutive dockings and as “experienced” with > 5 consecutive dockings. From 10/2023 to 08/2024, 82 procedures were performed with the Hugo RAS. For the evaluation 75 procedures could be considered. The mean docking time was 7.6 ± 3.5 min. There was a reduction in docking time from 13.5 ± 3.7 min in the first 5 procedures to 4.4 ± 0.9 min in the last 5 procedures (p < 0.001). Docking with laser (n = 45) was faster than without laser (n = 30) (6.2 ± 2.5 vs. 9.8 ± 3.7 min, p < 0.001). Faster docking time was observed with inexperienced surgical nursing staff with laser than without laser (10.4 ± 3.7 vs. 5.4 ± 1.4 min; p < 0.001). With experienced nursing staff, the laser had no influence (6.6 ± 1.3 vs. 6.7 ± 2.9 min; p = 0.9). As a reference docking time for daVinci Xi procedures was 2.4 ± 1.7 min (n = 5). Laser-guided cart positioning has a significant impact on docking time, especially for unexperienced medical personnel. Especially in the times of experienced staff shortage, laser-guided cart positioning can save operating time.
Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface
Authors: Garven Ellen E. , Kung Ethan , Stevens Randy M. , Throckmorton Amy L. 
Published: January 2025

Abstract
Purpose
Computational models of the cardiovascular system continue to increase in complexity. As more elements of the physiology are captured in multiscale models, there is a need to efficiently integrate subsystems. The objective of this study is to demonstrate the effectiveness of a coupling methodology, called functional mock-up interface (FMI), as applied to multiscale cardiovascular modeling.

Methods
The multiscale model is composed of two subsystems: a computational fluid dynamics (CFD) model coupled to a lumped parameter model (LPM). The LPM is packaged using the FMI standard and imported into the CFD subsystem using an FMI co-simulation architecture. The functionality of an FMI coupling was demonstrated in a univentricular parallel circulation by means of compatible tools, including ANSYS CFX and Python. Predicted pressures and flows were evaluated in comparison with clinical data and a previously developed computational model.

Results
The two models exchanged pressure and flow data between their boundaries at each timestep, demonstrating sufficient inter-subsystem communication. The models recreated pressures and flows from clinical measurements and a patient-specific model previously published.

Conclusion
FMI integrated with ANSYS CFX is an effective approach for interfacing cardiovascular multiscale models as demonstrated by the presented univentricular circulatory model. FMI offers a modular approach towards tool integration and is an advantageous strategy for modeling complex systems.
Discovery of a parallel family of euglenatide analogs in Euglena gracilis
Authors: Elbanna Ahmed H. , Kou Xinhui , Prajapati Dilip V. , Rakshit Surasree , Butcher Rebecca A. 
Published: January 2025

AbstractThe euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae produce not only the euglenatides, but also a corresponding family of analogs that have the same molecular weights as the euglenatides, but are lacking the characteristic triene chromophore. In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides.
Graphical abstract
Teacher characteristics influencing plant biology education: age, perception, and practical engagement
Authors: Vydra Marek , Kováčik Jozef 
Published: January 2025

AbstractPlants are less attractive for students compared to other areas of biology, and teachers may improve this negative scenario. We aimed to investigate the influence of several characteristics of the teacher (e.g. gender, age or technical equipment) on (i) the activity of teaching plant biology, (ii) a number of physiological experiments used in teaching and, (iii) deficiencies in the knowledge of students in plant biology. For this purpose, data were extracted from previous more complex survey and analyzed by General Linear Model. The age, the teachers’ perception of the students’ knowledge and the teachers’ awareness of the importance of the aids significantly correlated with the teachers’ activity in education. Similarly, three teachers’ characteristics (age, school’s equipment and awareness of the importance of the aids) correlated with the number of implemented physiological experiments. In addition, two teachers’ characteristics (age and perception of the students’ knowledge) significantly correlated with the number of identified gaps in students’ knowledge. In particular, we found that 51-yr-old (or above) teachers use more practical activities and physiological experiments, which may be the reason why they identified fewer gaps in students’ knowledge. Therefore, these more active teachers should be replaced by young teachers of the same quality after their retirement to keep the quality of education.
Graphical abstract
Characterization of the pH-Dependent Disintegration of Chemically Modified Alginate Hydrogels
Authors: Morningstar John , Alwan Abdelrahman , Dixon Timothy , Opara Emmanuel C. , Welker Mark E. 
Published: January 2025

Abstract
Introduction
We previously showed that chemical modification of alginate with 4-(2-aminoethyl) benzoic acid (ABA) results in the generation of alginate hydrogel microbeads that are resistant to disintegration in acidic pH but sensitive in near-neutral and basic pH conditions.

Aim
In the present study, we sought to better understand the chemical origin of the pH dependence of the ABA-modified alginate. We had hypothesized that ABA-modified alginate would be stable at acidic pH where the carboxylic acid functional group would be protonated and more unstable/water soluble at near-neutral to basic pH where the carboxylate would be ionic.

Materials and Method
To test this hypothesis, we added three separate small molecule attachments to the same alginate backbone in addition to the ABA-modified alginate so that their pH-dependent disintegration rates could be compared.

Results
We found that the disintegration profiles of phenethylamine- and ABA-modified alginates were similar, but different from those of methyl 4-(2-aminoethyl) benzoate- and 1-[4-(2-aminoethyl)-phenyl] ethanone-alginates.

Conclusion
In summary, we have developed an effective platform suitable for oral delivery of therapeutic agents, which normally would not be considered for oral administration. Through simple chemical alginate modifications, we have prepared a small family of new alginates that can disintegrate over 30–120 min at near-neutral pHs, thus providing useful information on how the polyanionic alginate polymer can be functionalized for enhanced oral delivery of therapeutic substances.

Lay Summary
We recently developed a macromolecule in which 4-(2-aminoethyl) benzoic acid (ABA) was attached to the alginate backbone. In the present study, we have compared the disintegration profiles of ABA-modified alginate with those of three separate small molecule attachments to alginate. The disintegration of phenethylamine- and ABA-modified alginate hydrogels were similar but different from those of methyl 4-(2-aminoethyl) benzoate- and 1-[4-(2-aminoethyl)-phenyl] ethanone-alginates. In conclusion, we have prepared a small family of new alginates that can disintegrate over 30–120 min at near-neutral pH, thus providing useful information on how alginate can be chemically altered for enhanced oral delivery of therapeutic substances.

Future Work
In further studies, we will examine the efficacy of using these compounds for oral delivery of therapeutic proteins and peptides in an appropriate preclinical animal model to set the stage for application in human trials.
Power-energy decoupling with source-typed flexible load: an optimal scheduling strategy for integrated energy systems with multi-flexibility resources
Authors: Shi Pingyuan , Wang Xingce , Hao Junhong , Hong Feng , Liu Hongtao , Du Xiaoze 
Published: January 2025

AbstractDeep exploration of user-side flexibility resources is crucial for large-scale renewable energy consumption. This paper proposed a typical integrated energy system (IES) that comprehensively includes wind power, photovoltaic, thermal power, combined heat and power, hybrid energy storage, and flexible load and constructed the system’s unified power flow model based on the heat current method. On this basis, the regulation capabilities of different typical industrial and residential flexible loads were considered the symmetrical source-type load, which can transfer load and align user demand with the peaks and valleys of renewable energy generation, thus achieving power-energy decoupling. This contributes effectively to renewable energy accommodation capacity when the total electrical energy consumption remains constant. In both typical industrial and residential load scenarios, flexible load reduces integrated costs, increases renewable energy consumption, lowers peak thermal power generation, and decreases the requirement for a battery energy storage system (BESS). Besides, on typical industrial and residential load days, smoothing thermal power generation necessitates 12% and 18% flexible load, respectively, while replacing BESS requires 18% and 23% flexible load, respectively. Therefore, we can obtain the feasible operation ranges of symmetrical source-type load and provide suggestions for configuration capacity design of demand response in integrated energy systems.
Rational design of nitrogen and fluorine co-doped metal-free porous carbons electrocatalysts for highly efficient oxygen reduction and zinc-air batteries
Authors: Li Linqiang , Qin Na , Ma Huayun , Liu Jing , Zhu Zhiqiang , Huo Yaxiong , Zhai Lipeng , Mi Liwei 
Published: January 2025

AbstractThe oxygen reduction reaction (ORR) is an important reaction in fuel cells and metal air batteries. The reaction is affected by slow kinetics and the use of high-priced and resource-scarce platinum-based catalysts. Therefore, there is an urgent need to develop cost-effective nonprecious metal catalysts for use in the ORR to replace Pt-based catalysts. In this study, we used two-dimensional covalent organic frameworks (recorded as TF-COFs) as precursors to produce a metal-free nitrogen and fluorine-co-doped porous carbon catalyst (recorded as TF-800, TF-900, TF-1000, and TF-1100). TF-1000 had a high initial potential (0.90 V) and half-wave potential (0.83 V) in an alkaline medium, indicating good catalytic activity. In addition, the ORR stability of TF-1000 was better than that of commercial Pt/C (20%). This is mainly because the porous carbon catalyst has a high specific surface area, and the nitrogen and fluorine atoms in it have good dispersion and synergistic effects on the polarization of adjacent carbon atoms. TF-1000 also shows excellent performance in zinc-air batteries. In the TF-1000 based zinc-air batteries, excellent battery performance was observed: the peak power density reached 216.66 mW·cm–2, the specific capacity reached 752.86 mAh·g–1 at 10 mA·cm–2, and the long-term charge–discharge stability was demonstrated. This work provides inspiration for new strategies to prepare future ORR catalysts.
Convergent synergy of carbon capture within the circular economy paradigm: a nexus for realizing multifaceted sustainable development goals
Authors: Gautam Pratibha , Salunke Darshan , Lad Divya , Gautam Arun 
Published: January 2025

AbstractCarbon capture and storage (CCS) is an advanced technological solution that captures carbon dioxide (CO2) emissions from sources such as power plants and industrial facilities, storing them underground to prevent atmospheric release and mitigate climate change. Despite its potential to significantly reduce greenhouse gas emissions, CCS faces challenges like high costs and environmental concerns. Simultaneously, the circular economy model offers a transformative approach by minimizing waste and maximizing resource efficiency through strategies like recycling, reusing, and redesigning products for extended lifecycles. Integrating CCS within the circular economy framework presents a unique opportunity to enhance sustainability by repurposing captured CO2 for applications in chemical production, fertilizers, and other industrial processes, thereby aligning with circular principles of resource optimization. This synergy not only reduces carbon footprints but also supports Sustainable Development Goals by addressing economic, environmental, and social challenges. Furthermore, the combined approach can create socio-economic benefits, such as generating new green jobs and fostering a more resilient and sustainable future. This paper explores the integration of CCS with the circular economy, demonstrating how these combined initiatives contribute to a balanced relationship with the environment and promote a holistic pathway toward achieving sustainable development goals.
Graphical Abstract
Early detection of marine bioinvasion by sun corals using YOLOv8
Authors: Luz Ana Carolina N. , Barroso Viviane R. , Batista Daniela , Lessa Aléxia A. , Coutinho Ricardo , Xavier Fábio C. 
Published: January 2025

AbstractSun coral (Tubastraea spp.) is an invasive species that poses a considerable threat to coastal ecosystems. Therefore, early detection is essential for effective monitoring and mitigation of its negative impacts on marine biodiversity. This study presents a novel computer vision approach for automated early detection of invasive Tubastraea species in underwater images. We used the YOLOv8 object detection model, which was trained and validated on a manually annotated dataset augmented with synthetic images. The data augmentation addressed the challenge of limited training data that is prevalent in underwater environments. The model achieved performance metrics (in terms of precision accuracy, recall, mAP50, and F1 score) of over 90% and detected both open and closed coral stage classes. Test phase results were compared with expert validation, demonstrating the model’s effectiveness in rapid detection (16 ms) and its limitations in areas highly covered by Tubastraea. This study demonstrates the potential of deep learning with data augmentation to facilitate the rapid assessment of large image datasets in monitoring sun coral bioinvasion. This approach has the potential to assist managers, taxonomists, and other professionals in the control of invasive alien species.
Toward ecosystem-based deep-sea governance: a review of global approaches and China’s participation
Authors: Yu Ting , Liu Rui , Jin Ying 
Published: January 2025

AbstractThe deep sea is an expansive and largely unexplored domain, and its effective governance requires concerted international efforts. Despite the existence of international frameworks, the current deep-sea governance structures are somewhat fragmented, led by selected entities, and address only a limited range of issues. This study examines the current landscape of international deep-sea governance, exploring the organizational frameworks, institutional structures, key actors, pressing issues, and management instruments. It also analyzes the multiple challenges that confront deep-sea governance in light of the imperative for developing an ecosystem-based approach. Furthermore, the study evaluates China’s engagement in international deep-sea governance in terms of following international conventions and contributing to scientific and technological advancements. Moreover, guided by the principles of a maritime community in a shared future, pathways for enhanced participation in ecosystem-based deep-sea governance are proposed.
Reducing antibiotic duration for acute otitis media: clinician, administrator, and parental insights to inform implementation of system-level interventions
Authors: Rinehart Deborah J. , Gilbert Aiden , O’Leary Sonja , Katz Sophie E. , Frost Holly M. 
Published: January 2025

Abstract

Objective:
This qualitative study aimed to understand facilitators and barriers to implementation of interventions to improve guideline-concordant antibiotic duration prescribing for pediatric acute otitis media (AOM).

Design:
Clinicians and clinic administrators participated in semi-structured qualitative interviews, and parents of children 2 years of age or older with a recent diagnosis of AOM participated in focus groups. The Practical Robust Implementation and Sustainability Model (PRISM) guided the study. Interviews were analyzed using the Rapid Assessment Process.

Setting:
Denver Health and Hospital Authority (Denver, CO) led the study. Recruitment occurred at Vanderbilt University Medical Center (Nashville, TN) and Washington University in St. Louis Medical Center (St. Louis, MO).

Participants:
Purposeful sampling was used to recruit clinicians and administrators for qualitative interviews. Convenience sampling was used to recruit parents for focus groups.

Results:
Thirty-one participants (15 clinicians, 4 administrators, and 12 parents) engaged in interviews and focus groups. Factors influencing antibiotic prescribing included patient history, years of practice, familiarity with the patient, concerns with patient medication adherence, and practice type. Clinicians endorsed electronic health record modifications and clinician prescribing feedback as methods to improve patient care and reduce the durations of prescribed antibiotics. Suggestions for intervention optimization and education needs were also obtained.

Conclusions:
Findings suggest that clinicians and administrators support reducing prescribed antibiotic durations for AOM and are receptive to the proposed interventions. More education is needed to increase parent awareness about antibiotic stewardship and AOM treatment options.

Clinical trials identifier:
RELAX: Reducing Length of Antibiotics for Children with Ear Infections (RELAX), NCT05608993, https://clinicaltrials.gov/study/NCT05608993.
Efficacy of priming and commitment posters on urgent care patients’ antibiotic expectations and knowledge: a cluster randomized trial
Authors: Cziner Michael J. , Park Daniel E. , Hamdy Rana F. , Rogers Laura , Turner Monique M. , Liu Cindy M. 
Published: January 2025

Abstract

Objective:
Successfully educating urgent care patients on appropriate use and risks of antibiotics can be challenging. We assessed the conscious and subconscious impact various educational materials (informational handout, priming poster, and commitment poster) had on urgent care patients’ knowledge and expectations regarding antibiotics.

Design:
Stratified Block Randomized Control Trial.

Setting:
Urgent care centers (UCCs) in Colorado, Florida, Georgia, and New Jersey.

Participants:
Urgent care patients.

Methods:
We randomized 29 UCCs across six study arms to display specific educational materials (informational handout, priming poster, and commitment poster). The primary intention-to-treat (ITT) analysis evaluated whether the materials impacted patient knowledge or expectations of antibiotic prescribing by assigned study arm. The secondary as-treated analysis evaluated the same outcome comparing patients who recalled seeing the assigned educational material and patients who either did not recall seeing an assigned material or were in the control arm.

Results:
Twenty-seven centers returned 2,919 questionnaires across six study arms. Only 27.2% of participants in the intervention arms recalled seeing any educational materials. In our primary ITT analysis, no difference in knowledge or expectations of antibiotic prescribing was noted between groups. However, in the as-treated analysis, the handout and commitment poster were associated with higher antibiotic knowledge scores.

Conclusions:
Educational materials in UCCs are associated with increased antibiotic-related knowledge among patients when they are seen and recalled; however, most patients do not recall passively displayed materials. More emphasis should be placed on creating and drawing attention to memorable patient educational materials.
Injury Spectrum and Radiology Department Response Assessment Following the Beirut Blast
Authors: El-Haddad Joya , Jardali Ghina , Farah Fadi , Hoyek Nadine , Haddad Antoine 
Published: January 2025

Abstract

Objectives
The catastrophic Beirut blast on August 4, 2020 at 6:07 pm resulted in extensive damage. Our study aims to categorize the injuries of patients who were transferred to the radiology department in the first 12 hours following the blast and to evaluate the disaster preparedness of the radiology department at Hôtel-Dieu de France Hospital in order to implement corrective action process.

Methods
A total of 97 patients underwent imaging examinations, comprising 77 CT scans and 20 radiographs, which were retrospectively reviewed by 4 senior radiology residents. Patient injuries were classified according to blast injury categories. A full assessment of our disaster plan was done including staff shortage, examination time, patients triage and diagnostic performance of radiologists.

Results
Tertiary injuries were the most prevalent (47.6%). Maxillofacial fractures and intracranial hemorrhage were the most common (54.3%). The radiology department encountered numerous challenges, including communication difficulties, staffing shortages and infrastructure damage. Nevertheless, the disaster management plan enabled the department to effectively navigate these obstacles despite many flaws and many lessons were learned.

Conclusions
This study underscores the importance of an efficient response of the radiology team during mass casualty incidents and can inform future disaster preparedness efforts in health care settings.