bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between close interpersonal contact and vaccine hesitancy: Findings from a population-based survey in Canada
Authors: Adu Prince A. , Iyaniwura Sarafa A. , Mahmood Bushra , Jeong Dahn , Makuza Jean Damascene , Cua Georgine , Binka Mawuena , García Héctor A. Velásquez , Ringa Notice , Wong Stanley , Yu Amanda , Irvine Mike A. , Otterstatter Michael , Janjua Naveed Z. 
Published: October 2022

BackgroundVaccine hesitancy threatens efforts to bring the coronavirus disease 2019 (COVID-19) pandemic to an end. Given that social or interpersonal contact is an important driver for COVID-19 transmission, understanding the relationship between contact rates and vaccine hesitancy may help identify appropriate targets for strategic intervention. The purpose of this study was to assess the association between interpersonal contact and COVID-19 vaccine hesitancy among a sample of unvaccinated adults in the Canadian province of British Columbia (BC).MethodsUnvaccinated individuals participating in the BC COVID-19 Population Mixing Patterns Survey (BC-Mix) were asked to indicate their level of agreement to the statement, “I plan to get the COVID-19 vaccine.” Multivariable multinomial logistic regression was used to assess the association between self-reported interpersonal contact and vaccine hesitancy, adjusting for age, sex, ethnicity, educational attainment, occupation, household size and region of residence. All analyses incorporated survey sampling weights based on age, sex, geography, and ethnicity.ResultsResults were based on survey responses collected between March 8, 2021 and December 6, 2021, by a total of 4,515 adults aged 18 years and older. Overall, 56.7% of respondents reported that they were willing to get the COVID-19 vaccine, 27.0% were unwilling and 16.3% were undecided. We found a dose-response association between interpersonal contact and vaccine hesitancy. Compared to individuals in the lowest quartile (least contact), those in the fourth quartile (highest contact), third quartile and second quartile groups were more likely to be vaccine hesitant, with adjusted odd ratios (aORs) of 2.85 (95% CI: 2.02, 4.00), 1.91(95% CI: 1.38, 2.64), 1.78 (95% CI: 1.13, 2.82), respectively.ConclusionStudy findings show that among unvaccinated people in BC, vaccine hesitancy is greater among those who have high contact rates, and hence potentially at higher risk of acquiring and transmitting infection. This may also impact future uptake of booster doses.
C-reactive protein to lymphocyte ratio as a new biomarker in predicting surgical site infection after posterior lumbar interbody fusion and instrumentation
Authors: Wu Xiaofei , Ma Xun , Zhu Jian , Chen Chen 
Published: October 2022

PurposeThis study aims to evaluate the potential of C-reactive protein to lymphocyte count ratio (CLR) for the prediction of surgical site infection (SSI) following posterior lumbar interbody fusion (PLIF) and the instrumentation of lumbar degenerative diseases.MethodsIn this retrospective study, we considered patients with a lumbar degenerative disease diagnosis surgically treated by the instrumented PLIF procedure from 2015 to 2021. Patient data, including postoperative early SSI and other perioperative variables, were collected from their respective hospitalization electronic medical records. The receiver operator characteristic curve was constructed to determine the optimal cut-off value for CLR, and the ability to predict SSI was evaluated by the area under the curve (AUC). According to the cut-off value, patients were dichotomized with high- or low-CLR, and between-group differences were compared using univariate analysis. The independent impact of CLR on predicting SSI was investigated by multivariate logistics regression analysis.ResultsA total of 773 patients were included, with 26 (3.4%) developing an early SSI post-operation. The preoperative CLR was 11.1 ± 26.1 (interquartile range, 0.4–7.5), and the optimal cut-off was 2.1, corresponding to a sensitivity of 0.856, a specificity of 0.643, and an AUC of 0.768 (95% CI, 0.737–0.797). CLR demonstrated a significantly improved prediction ability than did lymphocyte count (P = 0.021) and a similar ability to predict an infection as C-response protein (P = 0.444). Patients with a high CLR had a significantly higher SSI incidence than those with a low CLR (7.6% vs. 0.8%, P &lt; 0.001). After adjustment for numerous confounding factors, CLR ≥ 2.1 was associated with an 11.16-fold increased risk of SSI, along with other significant variables, i.e., diabetes, preoperative waiting time, and surgical duration.ConclusionA high CLR exhibited an improved ability to predict incident SSI and was associated with a substantially increased risk of SSI following instrumented PLIF. After better-design studies verified this finding, CLR could potentially be a beneficial tool in surgical management.
Colorectal endometriosis: Diagnosis, surgical strategies and post-operative complications
Authors: Alborzi Saeed , Roman Horace , Askary Elham , Poordast Tahereh , Shahraki Mahboobeh Hamedi , Alborzi Soroush , Hesam Abadi Alimohammad Keshtvarz , Najar Kolaii Elnaz Hosseini 
Published: October 2022

ObjectiveThe present work aimed to investigate the feasibility, complications, recurrence rate, and infertility outcomes of the radical and conservative surgical methods for colorectal endometriosis in short- and long-term follow-ups.MethodsIn this prospective study, the patients with confirmed diagnosis of colorectal DIE were included from March 2015 to March 2021, who were referred to an Endometriosis Surgery Center affiliated with Shiraz University of Medical Sciences (SUMS). Information on demographics, surgical approaches, intra-operative, and post-operative findings as well as complications were collected and compared. Six- and 12-month interviews were conducted to evaluate the functional outcomes of all the procedures.ResultsOut of 3,111 patients who underwent endometriosis surgery, 837 (28.19%) with the average age of 34.2 ± 5.9 years and average ASRM score of 102.1 ± 36.8 had rectosigmoid endometriosis. Laparoscopic rectal shaving was performed in 263(30.0%) patients while 326 (37.2%) underwent segmental bowel resection, and 248 (28.30%) were treated with disc excision. Prophylactic ileostomy was performed in six (0.68%) patients and peritonitis was reported in four (0.45%). Five (0.58%) subjects developed rectovaginal fistula and one (0.11%) was diagnosed with bladder atonia. The recurrence rate was 3.8%, 1.2%, and 0.3% in rectal shaving, disc, and segmental bowel resection techniques, respectively. Dysmenorrhea, dyspareunia, and dyschezia were improved after surgery by 7.3, 9.4, and 12.5 times, respectively. We observed 25.2% of total pregnancy following the operation, the majority of which occurred in the first year after the surgery.ConclusionThere were very few short-term or long-term complications in the three different techniques when the choice was correct.
Simplified Roux-en-Y reconstruction after laparoscopic radical distal gastrectomy for gastric cancer
Authors: Qian Yawei , Zhou Guang , Chang Feifei , Ping Xiaochun , Wang Guoliang 
Published: October 2022

BackgroundAlthough there were a variety of strategies for the alimentary tract reconstruction of patients with gastric cancer who underwent laparoscopic radical distal gastrectomy, it remains controversial regarding which procedure is optimal. We developed a simple technique for Roux-en-Y reconstruction during laparoscopic surgery and evaluated its technical feasibility and safety.MethodsSeventy-one cases of modified Roux-en-Y reconstructions after laparoscopic radical distal gastrectomy were consecutively performed in our hospital, from November 2020 to March 2022. A retrospective review of medical data was conducted. Intraoperative and postoperative outcomes, including operation time and incidence of postoperative complications, were collected and analyzed.ResultsAll procedures of laparoscopic distal gastrectomy with D2 lymph node dissection were successfully completed without any intraoperative complication. The mean number of retrieved lymph node was 38.8 ± 10.6. Mean operative time was 223.5 ± 42.4 min, whereas intraoperative blood loss was 102.2 ± 96.3 ml. No postoperative mortality was recorded. Six patients (8.5%) experienced postoperative complications and were managed conservatively. In addition, only two patients (2.8%) required rehospitalization during a median short-term follow-up period of 6 months.ConclusionsThe modified method is a simple and safe approach for laparoscopic radical distal gastrectomy.
Comparison of posterior decompression techniques and conventional laminectomy for lumbar spinal stenosis
Authors: Zhang Yong , Wei Fei-Long , Liu Zhi-Xin , Zhou Cheng-Pei , Du Ming-Rui , Quan Jian , Wang Yan-Peng 
Published: October 2022

ObjectivesTo compare the efficacy of posterior decompression techniques with conventional laminectomy for lumbar spinal stenosis.MethodsThe Embase, PubMed, and Cochrane Library databases were searched with no language limitations from inception to January 13, 2022. The main outcomes were functional disability, perceived recovery, leg and back pain, complications. A random effects model was used to pooled data. Risk ratio (RR), mean difference (MD) and 95% confidence interval (CI) were used to report results. The study protocol was published in PROSPERO (CRD42022302218).Results14 trials including 1,106 participants were included in the final analysis. Bilateral laminotomy was significantly more efficacious in improve functionality than laminectomy [MD: −2.94; (95% CI, −4.12 to −1.76)]. Low incidence of iatrogenic instability due to bilateral laminectomy compared with laminectomy [RR: 0.11; (95% CI, 0.02 to 0.59)]. In addition, between those who received bilateral laminotomy and those undergoing laminectomy, the result showed significant difference regarding recovery [RR: 1.31; (95% CI, 1.03 to 1.67)].ConclusionsThis study provides evidence that bilateral laminotomy has advantages in functional recovery, postoperative stability, and postoperative rehabilitation outcomes. Further research is needed to determine whether posterior techniques provide a safe and effective option for conventional laminectomy.
Effect of foliar fertilization and soil conditioners on the rooting of a hybrid of Pinus tecunumanii vs. Pinus caribaea var. honduransis
Authors: Gomes dos Santos Kaline , Duque Silva Luciana , Gomes Rodrigues Gleice 
Published: October 2022

As técnicas de produção de mudas via propagação vegetativa, constituem formas alternativas da reprodução sexuada (uso de sementes), no entanto, diversos fatores prejudicam sua utilização de forma abrangente, como por exemplo baixas taxas de enraizamento de algumas espécies. O objetivo desse estudo foi avaliar o efeito de adubos foliares e condicionadores de substrato nas taxas de enraizamento, crescimento e produção de minestacas clonais de híbridos de Pinus tecunumanii vs. caribaea var. hondurensis. Os experimentos foram desenvolvidos em viveiro florestal na cidade de Paranapanema-SP, com delineamento de blocos ao acaso, em arranjo fatorial 4x2. Foram utilizados quatro adubos foliares: AF1 à base de quitosana, AF3 à base de ácido húmico, AF4 extrato de Ascoplhyllum nodosum, e M2AF (mistura de AF1+AF3+AF4, 33,3% de cada) e dois condicionadores de substratos: C1 à base de pescados marinhos; C2 à base de ácidos húmicos. As minestacas foram avaliadas nas fases de casa de vegetação (taxa de enraizamento) e casa de sombra (altura total, massa seca e verde da parte aérea e radicular). O adubo foliar AF4 proporcionou maiores taxas de enraizamento das mudas, juntamente com o adubo AF3 combinado com o condicionador de substrato C2 e o adubo AF1 combinado como condicionador de substrato C2. Em geral, o adubo foliar AF4 promoveu maiores taxas de produção de biomassa vegetal.
Belatacept-Based Maintenance Immunosuppression Controls the Post-Transplant Humoral Immune Response in Highly Sensitized Nonhuman Primates
Authors: Schmitz Robin , Fitch Zachary W. , Manook Miriam , Schroder Paul M. , Choi Ashley Y. , Olaso Danae , Yoon Janghoon , Bae Yeeun , Shaw Brian I. , Song Mingqing , Kuchibhatla Maragatha , Farris Alton B. , Kirk Allan , Kwun Jean , Knechtle Stuart J. 
Published: October 2022

Key Points

Belatacept-based maintenance immunosuppression prevents antibody-mediated rejection and enables long-term kidney allograft survival in sensitized nonhuman primate recipients.Post-transplant belatacept prevents the rebound of follicular helper T cells, class-switched B cells, and antibody-secreting cells.Additional belatacept with tacrolimus increases the risk of viral reactivation and post-transplant lymphoproliferative disease.

Preexisting donor-specific antibodies (DSA) to MHC antigens increase the risk of antibody-mediated rejection (AMR) in sensitized transplant recipients and reduces graft survival. Pretransplant desensitization with costimulation blockade and proteasome inhibition has facilitated transplantation in our preclinical nonhuman primate (NHP) model. However, long-term graft survival is limited by rebound of DSA after transplantation. In this study, we performed kidney transplants between highly sensitized, maximally MHC-mismatched NHPs (n=14). At kidney transplantation, primates received T cell depletion with rhesus-specific anti-thymocyte globulin (rhATG; n=10) or monoclonal anti-CD4 and anti-CD8 antibodies (n=4). Maintenance immunosuppression consisted of belatacept and tacrolimus (n=5) or belatacept and rapamycin (n=9) with steroids. Rebound of DSA post–kidney transplantation was significantly reduced compared with maintenance immunosuppression with tacrolimus, mycophenolate, and steroids. Protocol lymph node biopsy specimens showed a decrease in germinal center activity, with low frequencies of T follicular helper cells and class-switched B cells after kidney transplantation. Combined belatacept and rapamycin was superior in controlling viral reactivation, enabling weaning of ganciclovir prophylaxis. Tacrolimus was associated with increased morbidity that included cytomegalovirus and parvovirus viremia and post-transplant lymphoproliferative disorder. All primates in the tacrolimus/belatacept group failed discontinuation of antiviral therapy. Overall, belatacept-based immunosuppression increased AMR-free graft survival by controlling post-transplant humoral responses in highly sensitized NHP recipients and should be further investigated in a human clinical trial.
The Orbital Complications of Acute Rhinosinusitis in Pediatric Patients: Observational Study
Authors: Улашев Ш.Х. , Махмудова С. , Хушвакова Н.Ж. 
Published: October 2022

Цель. Описание опыта орбитальных осложнений острого риносинусита в педиатрической популяции и выявление факторов риска, связанных с тяжестью заболевания.Материалы и методы. В данном ретроспективном исследовании оценивались клинические показатели 78 детей, госпитализированных по поводу орбитальных осложнений в период с 2005 по 2020 г. Для изучения демографических данных и клинических симптомов использовалась описательная статистика.Результаты. Несмотря на антибактериальную терапию на догоспитальном этапе среди пациентов наблюдались постсептальные орбитальные осложнения. Была обнаружена статистически значимая связь между возрастом пациентов при поступлении и тяжестью заболевания. Дети старше семи лет имели более тяжелые орбитальные осложнения и чаще нуждались в хирургическом вмешательстве (p<0,001).Выводы. В данном исследовании орбитальные осложнения II и III стадии при поступлении и старший возраст были наиболее важными факторами, определяющими неэффективность медикаментозного лечения. Дети старше семи лет с острым риносинуситом должны быть направлены к оториноларингологу для эффективного лечения и предупреждения орбитальных осложнений.
Purpose. To describe the experience of orbital complications of ARS in the paediatric population and to identify risk factors associated with disease severity.Materials and methods. This retrospective analysis evaluated the clinical outcomes of 78 children hospitalised for orbital complications between 2005 and 2020. Descriptive statistics were used to examine demographic data and clinical symptoms.Results. Although all children were treated with antibiotics prior to hospitalisation, more than half of this cohort experienced post-septal orbital complications. A significant association was found between age at admission and severity of illness. Children over seven years of age had more severe orbital complications and were more likely to require surgical intervnetion (p<0.001).Conclusions. In this study, stage II and III orbital complications at admission and older age were the most important determinants of failure of medical treatment. Early referral to an otolaryngologist should be considered for children older than seven years with ARS in order to assure an effective treatment and avoid orbital complications.
Results of Surgical Treatment of Inverted Papilloma of the Nasal Cavity and Paranasal Sinuses Using External Approaches
Authors: Морозова Н.А. , Колядич Ж.В. , Евмененко А.А. 
Published: October 2022

Цель. Проанализировать частоту рецидивов, 5-летнюю безрецидивную выживаемость, факторы риска рецидива инвертированной папилломы (ИП) полости носа (ПН) и околоносовых пазух (ОНП) у пациентов после хирургического лечения с применением наружных доступов.Материалы и методы. Выполнен ретроспективный анализ медицинской документации 35 пациентов с диагнозом ИП ПН и ОНП с малигнизацией или без нее, наблюдавшихся в РНПЦ ОМР им. Н.Н. Александрова с 2010 по 2021 г.Результаты. Частота малигнизации ИП составила 22,9%. Рецидивы развились у 16 (59,3%) пациентов. Частота рецидивов после ринотомии по Денкеру – 33,3%, после операции Колдуэлла – Люка – 80%. Пятилетняя безрецидивная выживаемость после операции в онкологическом стационаре – 54,5% (SE 11,9%; 95% ДИ 42,6–66,4%),операции в оториноларингологическом стационаре – 25,9% (SE 15,7%; 95% ДИ 10,2–41,6%). Различия в 5-летней безрецидивной выживаемости пациентов указанных подгрупп клинически и статистически значимы (р=0,013). Факторами, снижающими риск развития рецидива, являются: количество предшествующих операций по поводу полипозного риносинусита менее 2 (р=0,006), длительность затрудненного носового дыхания менее 6 месяцев (р=0,009), проведение первичной операции в онкологическом стационаре (р=0,006).Заключение. Хирургическое лечение ИП ПН и ОНП с применением наружных доступов показало высокую частоту рецидивов. Объем выполненной резекции влияет на частоту рецидивирования.
Purpose. To analyze the relapse rate, five-year relapse-free survival, risk factors for recurrence of inverted papilloma (IP) of the nasal cavity (NC) and paranasal sinuses (PNS) in patients after surgical treatment using external approaches.Materials and methods. A retrospective analysis of medical records of 35 patients diagnosed with IP NC and PNS with / without malignancy, observed in the N.N. Alexandrov National Cancer Centre from 2010 to 2021.Results. The frequency of IP malignancy was 22.9%. Relapses developed in 16 (59.3%) patients. The recurrence rate after Denker’s rhinotomy was 33.3%, after the Caldwell – Luc operation – 80%. Five-year recurrence-free survival after surgery in an oncological hospital – 54.5% (SE 11.9%; 95% CI 42.6–66.4%), surgery in an otorhinolaryngologicalhospital – 25.9% (SE 15.7%; 95% CI 10.2–41.6%). Differences in 5-year relapse-free survival of patients of these subgroups are clinically and statistically significant (p=0.013). Factors that reduce the risk of recurrence are: the number of previous surgeries for polyposis rhinosinusitis less than 2 (p=0.006), the duration of obstructed nasal breathing for less than 6 months (p=0.009), the primary operation in an oncology hospital (p=0.006).Conclusion. Surgical treatment of IP NC and PNS using external approaches showed a high recurrence rate. The amount of resection performed affects the recurrence rate.
Therapeutic Drug Monitoring for Topical Glucocorticoids: Using High-Performance Liquid Chromatography Method for Mometasone Furoate Detecting in Nasal Polyps
Authors: Афлитонов М.А. , Стрельникова Е.Г. , Безрукова Е.В. , Артюшкин С.А. , Воронов А.В. 
Published: October 2022

Введение. Стратификация истинной (биологической) резистентности к тГКС и ложной (кондуктивной) является критической задачей при лечении резистентных форм хронического полипозного риносинусита (ХПРС). Достоверное определение содержания тГКС в полипозной ткани может стать объективным методом контроля терапии при ХПРС.Цель. Определить качественное и количественное содержание мометазона фуроата в полипах носа методом высокоэффективной жидкостной хроматографии (ВЭЖХ).Материалы и методы. Проведено обследование фрагментов нативных тканей 101 пациента с ХПРС, возраст пациентов от 19 до 56 лет. Средний возраст составил (37,5±9,1) года. Среди них мужчин – 53 (52,47%), женщин – 48 (47,53%). Концентрацию мометазона фуроата определяли методом ВЭЖХ диализата полипозной ткани. Диализат полипозной ткани получали методом микродиализа нативных тканей человека.Результаты. С помощью метода ВЭЖХ при ХПРС на примере мометазона фуроата достоверно подтверждено наличие мометазона в полипозной, гипертрофированной и нативной ткани пациентов.Заключение. Разработан метод терапевтического лекарственного мониторинга при ХПРС на примере мометазона фуроата и ВЭЖХ, дающий достоверную информацию о концентрации действующего вещества в полипозной ткани пациента.
Introduction. Stratification of true (biological) resistance for topical glucocorticoids from false (conductive) is an urgent task in the treatment of resistant forms of chronic rhinosinusitis with nasal polyps.Purpose. The main goal of the study is to determine the quantitative and qualitative content of topical glucocorticoids in nasal polyps.Materials and methods. 101 patients were examined, the age of patients was from 19 to 56 years. The average age was (37.5±9.1) years. Men – 53 (52.47%), women – 48 (47.53%). Mometasone concentration was determined by HPLC method of polyposis tissue dialysate. Polypous tissue dialysate was obtained by microdialysis of native human tissues.Results. Using the HPLC method in CPRS, using mometasone furoate as an example, the presence of mometasone in healthy, hypertrophied and native tissue of patients was reliably confirmed.Conclusion. Therapeutic drug monitoring method for chronic rhinosinusitis with nasal polyps using mometasone furoate and high performance liquid chromatography has been developed. Drug monitoring provides reliable information about active substance concentration in the polyposis tissue of the patient. Topical agents testing model has been created (consisting of native polyps fragments, dialysis microtubules system and dialysate collection tank with micropump). Тesting model allows new drugs pharmacodynamics and pharmacokinetics studying.
Open innovation in the development of citizen science projects and improvement of the educational process at universities
Authors: Shchipanov E. F. 
Published: October 2022

The article analyzes the possibility of using the methods and tools of civil science in the implementation of scientiﬁc and innovative projects, as well as the improvement of educational programs in modern universities. Currently, an approach to the development of innovative projects open innovations is being developed, which involves the active involvement of all those interested in the implementation of the project in its development, testing and “market launch”. This requires the search for effective forms and tools for applying the potential of citizen science to the development of scientiﬁc and innovative projects and educational practices.