bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Universal Additive Strategy to Reshape Electrolyte Solvation Structure toward Reversible Zn Storage
Authors: Li Tian Chen , Lim YewVon , Li Xue Liang , Luo Songzhu , Lin Congjian , Fang Daliang , Xia Sunwen , Wang Ye , Yang Hui Ying 
Published: February 2022

AbstractThe benefits of Zn, despite many of its performance advantages (e.g., high theoretical capacity and low redox potential), are compromised by severe side reactions and Zn dendrite growth in aqueous electrolytes, due to the coordinated H2O within the Zn2+‐solvation sheath and reactive free water in the bulk electrolyte. Unlike most efforts focused on costly super‐concentrated electrolytes and single additive species, a universal strategy is proposed to boost Zn reversibility in dilute electrolytes via adding carbonyl‐containing organic solvents. Based on experimental investigations and multiscale simulations, the representative electrolyte with a N‐methyl‐2‐pyrrolidone polar additive is proved to assist in structural reshaping of Zn2+‐solvation and stabilizing the hydrogen bond network of water. This synergy is instrumental in contributing to suppressed water‐induced parasitic reactions and dendrite formation, which enables high average coulombic efficiency of 99.7% over 1000 cycles in an Zn/Cu asymmetric cell, and an ultralong cycling lifespan of 2000 cycles with 99.4% capacity retention in a Zn/VS2@SS full cell. Even with an elevated cathodic mass loading (up to 9.5 mg cm‐2), the cycling stability is still maintained. The proposed strategy provides new insight into electrolyte additive design and sheds light on high‐performance Zn‐ion batteries.
Characterizing the biomechanical differences between novice and expert point‐of‐care ultrasound practitioners using a low‐cost gyroscope and accelerometer integrated sensor: A pilot study
Authors: Prager Ross , Pageau Paul , Hodges Timothy , Yan Christina , Woo Michael , Nemnom Marie‐Joe , Millington Scott , Holden Matthew , St‐Gelais Raphael , Cheung Warren J. 
Published: February 2022

AbstractIntroductionPoint‐of‐care ultrasound (POCUS) has become an important diagnostic tool in acute care medicine; however, little is known about the biomechanical differences between novice and expert practitioners.MethodsA low‐cost ($50 CAD) gyroscope and accelerometer integrated sensor was assembled and affixed to an ultrasound probe. Seventeen participants, nine novices and eight experts, were recruited to perform three abdominal and four cardiac scans on a standardized patient. Participant demographics, time per scan, average acceleration, average angular velocity, decay in acceleration and angular velocity over time, and frequency of probe movements were analyzed. Video capture with blinded video review was scored.ResultsOn video review, experts had higher image optimization and acquisition scores for both abdominal and cardiac scans. Experts had shorter scan times for abdominal (7 s vs. 26 s,p = 0.003) and cardiac (11 s vs. 26 s,p < 0.001) scans. There was no difference in average acceleration (g) between novices and experts performing abdominal (1.02 vs. 1.01,p = 0.50) and cardiac (1.01 vs. 1.01,p = 0.45) scans. Experts had lower angular velocity (°/s) for abdominal scans (10.00 vs. 18.73,p < 0.001) and cardiac scans (15.61 vs. 20.33,p = 0.02) There was a greater decay in acceleration over time for experts performing cardiac scans compared to novices (−0.194 vs. −0.050,p = 0.03) but not for abdominal scans or when measuring angular velocity. The frequency of movements (Hz) was higher for novices compared to experts for abdominal (16.68 vs. 13.79,p < 0.001) and cardiac (17.60 vs. 13.63,p = 0.002) scans.DiscussionThis study supports the feasibility of a low‐cost gyroscope and accelerometer integrated sensor to quantify the biomechanics of POCUS. It may also support the concept of “window shopping” as a method by which experts obtain abdominal and cardiac views, where sliding is used to find an acoustic window, then smaller rocking and tilting probe movements are used to refine the image.
Modeling the axial distribution of mass transfer coefficient in an agitated‐pulsed extraction column
Authors: Tan Boren , Xu Ziyang , Wang Yong , Zhang Yanlin , Hu Yongqi , Qi Tao 
Published: February 2022

AbstractThe dispersed phase holdup and drop size in solvent extraction columns vary along the column height and this affects the mass transfer coefficient and interfacial area. In this article, mass transfer study was performed experimentally using a 25 mm diameter agitated pulsed column. The axial distribution of mass transfer coefficient was determined by coupling population balance equation and axial dispersion model by taking the longitudinal variation in hydrodynamic performance into consideration. Feasibility of different mass transfer models in predicting concentration profiles was evaluated and a novel correlation based on effective diffusivity was developed. The results showed that both overall and volumetric mass transfer coefficients have significant change along the column height and greatly depends on the agitation speed and pulsation intensity. Increasing dispersed phase velocity also augments the overall mass transfer coefficient. The maximum number of transfer unit was measured to be 10 m−1 at agitation speed of 1000 rpm.
Findings from a systematic review of fatigue interventions: What's (not) being tested in mining and other industrial environments
Authors: Dugdale Zoë , Eiter Brianna , Chaumont Menéndez Cammie , Wong Imelda , Bauerle Tim 
Published: February 2022

AbstractBackgroundFatigue negatively impacts mineworker health and safety. In this paper, we identify fatigue interventions tested on industrial shiftworkers and explore their effects and the factors that may influence application in an industrial setting such as a mine site.MethodsThis review adhered to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) checklist. A structured, systematic search of the literature was conducted to identify relevant studies published between 1980 and 2020. Researchers independently conducted article screening and study quality appraisals against pre‐established criteria, and then extracted data and conducted a narrative synthesis of the included studies.ResultsSeven intervention studies, out of 1651 articles initially screened, were retained for narrative synthesis. Four studies tested the alerting effects of bright‐light treatment, one evaluated the effectiveness of blue‐light blocking glasses at improving daytime sleep quality and nighttime vigilance, and two examined whether sleep hygiene and alertness management trainings improved sleep quality or alertness. There was substantial evidence for the use of bright‐light treatments to improve night shiftworker alertness, but insufficient evidence to draw conclusions about the effectiveness of blue‐light blocking glasses and sleep hygiene and alertness management trainings due to the small number of studies included. Shiftworkers were mostly male and employed in industrial subsectors such as production and manufacturing, oil and gas, and transportation. No mining‐specific intervention studies were identified.ConclusionsFuture research is needed to identify effective fatigue risk management interventions for the mining industry as well as best practices for implementing these interventions with mineworkers.
The impact of a “Psychiatric Genetics for Genetic Counselors” workshop on genetic counselor attendees: An exploratory study
Authors: Dillon Amy , Austin Jehannine , McGhee Kevin , Watson Melanie 
Published: February 2022

AbstractGenetic counseling is the process of supporting patients’ and families’ adaptation to genetic information. Psychiatric genetic counseling has been proven to be effective in improving empowerment, self‐efficacy, and knowledge even in the absence of genetic testing. Despite this, only one specialist psychiatric genetic counseling clinic currently exists. In order to engage genetic counselors in providing psychiatric genetic counseling, a 2‐day workshop: “Psychiatric Genetic Counseling for Genetic Counselors”, was developed and implemented aimed at empowering genetic counselors to feel confident and competent in this practice domain. The aim of the study was to qualitatively explore the impact of the workshop. Semistructured interviews were carried out with 12 genetic counselors who attended the workshop between 2015 and 2018. Thematic analysis revealed that the workshop empowered all participants to feel comfortable and confident offering psychiatric genetic counseling to patients. Participants also reflected how the workshop highlighted the stigma associated with mental illnesses and offered support in normalizing these conditions. Overall, this study presents that the “Psychiatric Genetic Counseling for Genetic Counselors” workshop fulfilled its proposed aims and outcomes.
Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise caused by rapid resumption after prolonged detraining
Authors: Takehara Kei , Mizobe Michiko , Endo Keita , Miyake Akihiro , Suzuki Toshihiko , Funakoshi Hiraku 
Published: February 2022

BackgroundWe report a case of acute renal failure with loin pain and patchy renal ischemia after anaerobic exercise (ALPE) caused by sudden training resumption.Case presentationA 19‐year‐old Asian man who was a college American football player presented with severe back pain, headache, and malaise. He developed acute kidney injury without myoglobinuria. Based on the typical medical history and symptoms, we made a diagnosis of ALPE. Symptoms improved within a few days, and serum creatinine levels improved after discharge. He resumed training, adjusting his load step by step.ConclusionDuring the coronavirus disease 2019 pandemic, many athletes were unable to undergo adequate training. Long‐term de‐training leads to decreased various organ function and reduces the anaerobic threshold. Rapid resumption after prolonged de‐training may put individuals at risk of developing ALPE.
Endovascular Thrombectomy Versus Medical Management in Isolated M2 Occlusions: Pooled Patient‐Level Analysis from the EXTEND‐IA Trials, INSPIRE, and SELECT Studies
Authors: Sarraj Amrou , Parsons Mark , Bivard Andrew , Hassan Ameer E. , Abraham Michael G. , Wu Teddy , Kleinig Timothy , Lin Longting , Chen Chushuang , Levi Christopher , Dong Qiang , Cheng Xin , Butcher Ken S. , Choi Philip , Yassi Nawaf , Shah Darshan , Sharma Gagan , Pujara Deep , Shaker Faris , Blackburn Spiros , Dewey Helen , Thijs Vincent , Sitton Clark W. , Donnan Geoffrey A. , Mitchell Peter J. , Yan Bernard , Grotta James G. , Albers Gregory W. , Davis Stephen M. , Campbell Bruce ,   SELECT Investigators, the EXTEND‐IA Investigators, the EXTEND‐IA TNK Investigators, the EXTEND‐IA TNK Part II Investigators, and the INSPIRE Study Group
Published: February 2022

ObjectiveThe objective of this study was to evaluate functional and safety outcomes of endovascular thrombectomy (EVT) versus medical management (MM) in patients with M2 occlusion and examine their association with perfusion imaging mismatch and stroke severity.MethodsIn a pooled, patient‐level analysis of 3 randomized controlled trials (EXTEND‐IA, EXTEND‐and IA‐TNK parts 1 and 2) and 2 prospective nonrandomized studies (INSPIRE and SELECT), we evaluated EVT association with 90‐day functional independence (modified Rankin Scale [mRS] = 0–2) in isolated M2 occlusions as compared to medical management overall and in subgroups by mismatch profile status and stroke severity.ResultsWe included 517 patients (EVT = 195 and MM = 322), baseline median (interquartile range [IQR]) National Institutes of Health Stroke Scale (NIHSS) was 13 (8–19) in EVT versus 10 (6–15) in MM, p < 0.001. Pretreatment ischemic core did not differ (EVT = 10 [0–24] ml vs MM = 9 [3–21] ml, p = 0.59). Compared to MM, EVT was more frequently associated with functional independence (68.3 vs 61.6%, adjusted odds ratio [aOR] = 2.42, 95% confidence interval [CI] = 1.25–4.67, p = 0.008, inverse probability of treatment weights [IPTW]‐OR = 1.75, 95% CI = 1.00–3.75, p = 0.05) with a shift toward better mRS outcomes (adjusted cOR = 2.02, 95% CI:1.23–3.29, p = 0.005), and lower mortality (5 vs 10%, aOR = 0.32, 95% CI = 0.12–0.87, p = 0.025). EVT was associated with higher functional independence in patients with a perfusion mismatch profile (EVT = 70.7% vs MM = 61.3%, aOR = 2.29, 95% CI = 1.09–4.79, p = 0.029, IPTW‐OR = 2.02, 1.08–3.78, p = 0.029), whereas no difference was found in those without mismatch (EVT = 43.8% vs MM = 62.7%, p = 0.17, IPTW‐OR: 0.71, 95% CI = 0.18–2.78, p = 0.62). Functional independence was more frequent with EVT in patients with moderate or severe strokes, as defined by baseline NIHSS above any thresholds from 6 to 10, whereas there was no difference between groups with milder strokes below these thresholds.InterpretationIn patients with M2 occlusion, EVT was associated with improved clinical outcomes when compared to MM. This association was primarily observed in patients with a mismatch profile and those with higher stroke severity. ANN NEUROL 2022;91:629–639
Self‐Assembly of Molecular Trefoil Knots Featuring Pentadecanuclear Homoleptic AuI‐, AuI/AgI‐, or AuI/CuI‐Alkynyl Coordination
Authors: Xu Guang‐Tao , Chang Xiao‐Yong , Low Kam‐Hung , Wu Liang‐Liang , Wan Qingyun , Shu Hui‐Xing , To Wai‐Pong , Huang Jie‐Sheng , Che Chi‐Ming 
Published: February 2022

AbstractMetal‐free and metal‐containing molecular trefoil knots are fascinating ensembles that are usually covalently assembled, the latter requiring the rational design of di‐ or multidentate/multipodal ligands as connectors. In this work, we describe the self‐assembly of pentadecanuclear AuI trefoil knots [Au15(C≡CR)15] from monoalkynes HC≡CR (R=9,9‐X2‐fluorenyl with X=nBu, n‐hexyl) and [AuI(THT)Cl]. Hetero‐bimetallic counterparts [Au9M6(C≡CR)15] (M=Cu/Ag) were self‐assembled by reactions of [Au15(C≡CR)15] with [Cu(MeCN)4]+/AgNO3 and HC≡CR. The type of pentadecanuclear trefoil knots described herein is characterized by X‐ray crystallography, 2D NMR and HR‐ESI‐MS. [Au9Cu6(C≡CR)15] is relatively stable in hexane; its excited state properties were investigated. DFT calculations revealed that non‐covalent metal–metal and metal–ligand interactions, together with longer alkyl chain‐strengthened inter‐ligand dispersion interactions, govern the stability of the trefoil knot structures.
Short Guanidinium‐Functionalized Poly(2‐oxazoline)s Displaying Potent Therapeutic Efficacy on Drug‐Resistant Fungal Infections
Authors: Jiang Weinan , Zhou Min , Cong Zihao , Xie Jiayang , Zhang Wenjing , Chen Sheng , Zou Jingcheng , Ji Zhemin , Shao Ning , Chen Xin , Li Maoquan , Liu Runhui 
Published: February 2022

AbstractNew antifungals are urgently needed to combat invasive fungal infections, due to limited types of available antifungal drugs and frequently encountered side effects, as well as the quick emergence of drug‐resistance. We previously developed amine‐pendent poly(2‐oxazoline)s (POXs) as synthetic mimics of host defense peptides (HDPs) to have antibacterial properties, but with poor antifungal activity. Hereby, we report the finding of short guanidinium‐pendent POXs, inspired by cell‐penetrating peptides, as synthetic mimics of HDPs to display potent antifungal activity, superior mammalian cells versus fungi selectivity, and strong therapeutic efficacy in treating local and systemic fungal infections. Moreover, the unique antifungal mechanism of fungal cell membrane penetration and organelle disruption explains the insusceptibility of POXs to antifungal resistance. The easy synthesis and structural diversity of POXs imply their potential as a class of promising antifungal agents.
Ratiometric and Colorimetric Optical Thermometers Using Emissive Dimeric and Trimeric {[Au(SCN)2]−}n Moieties Generated in d–f Heterometallic Assemblies
Authors: Kumar Kunal , Stefanczyk Olaf , Chorazy Szymon , Nakabayashi Koji , Ohkoshi Shin‐ichi 
Published: February 2022

AbstractGold complexes can generate excimers ([Au2]→[Au2]*) and exciplexes ([Au3]→[Au3]*) with light excitation. Four GdIII and YIII complexes were assembled with dimeric {[Au(SCN)2]−}2 and trimeric {[Au(SCN)2]−}3 bis(thiocyanato)gold(I) counterions. The vibrational signature associated with the Au⋅⋅⋅Au vibrational mode was probed with ultralow frequency (ULF) Raman spectroscopy as a function of temperature. Emission spectroscopy was used to explore photophysical properties. Two broad features in the high‐ and low‐energy regions were associated with the fluorescence and phosphorescence of the gold entities, respectively. Temperature‐dependent luminescence measurements showed that the emission color can be tuned from blue to green via cyan and white. Hence, these complexes can act as colorimetric thermometers. Additionally, a ratiometric thermal sensing ability was incorporated with high sensitivity up to 5 % K−1 in the cryogenic temperature range.
Enhanced Overall Water Splitting by a Zirconium‐Doped TaON‐Based Photocatalyst
Authors: Xiao Jiadong , Nishimae Shinji , Vequizo Junie Jhon M. , Nakabayashi Mamiko , Hisatomi Takashi , Li Huihui , Lin Lihua , Shibata Naoya , Yamakata Akira , Inoue Yasunobu , Domen Kazunari 
Published: February 2022

AbstractSolar‐powered one‐step‐excitation overall water splitting (OWS) using semiconducting materials is a simple means of achieving scalable and sustainable hydrogen production. While tantalum oxynitride (TaON) is one of the few photocatalysts capable of promoting OWS via single‐step visible‐light excitation, the efficiency of this process remains extremely poor. The present work employed 15 nm amorphous Ta2O5⋅3.3 H2O nanoparticles as a new precursor together with Zr doping and an optimized nitridation duration to synthesize a TaON‐based photocatalyst with reduced particle sizes and low defect densities. Upon loading with Ru/Cr2O3/IrO2 cocatalysts, this material exhibited stoichiometric water splitting into hydrogen and oxygen, with an order of magnitude improvement in efficiency. Our findings demonstrate the importance of inventing/selecting the appropriate synthetic precursor and of defect control for fabricating active OWS photocatalysts.
In Situ Constructed Nano‐Drug Depots through Intracellular Hydrolytic Condensation for Chemotherapy of Bladder Cancer
Authors: Hou Da‐Yong , Zhang Ni‐Yuan , Wang Man‐Di , Xu Shao‐Xin , Wang Zhi‐Jia , Hu Xing‐Jie , Lv Gan‐Tian , Wang Jia‐Qi , Wu Xiu‐Hai , Wang Lu , Cheng Dong‐Bing , Wang Hao , Xu Wanhai 
Published: February 2022

AbstractIntravesical administration of first‐line drugs has shown failure in the treatment of bladder cancer owing to the poor tumor retention time of chemotherapeutics. Herein, we report an intracellular hydrolytic condensation (IHC) system to construct long‐term retentive nano‐drug depots in situ, wherein sustained drug release results in highly efficient suppression of bladder cancer. Briefly, the designed doxorubicin (Dox)‐silane conjugates self‐assemble into silane‐based prodrug nanoparticles, which condense into silicon particle‐based nano‐drug depots inside tumor cells. Significantly, we demonstrate that theIHCsystem possesses highly potent antitumor efficacy, which leads to the regression and eradication of large established tumors and simultaneously extends the overall survival of air pouch bladder cancer mice compared with that of mice treated with Dox. The concept of intracellular hydrolytic condensation can be extended via conjugating other chemotherapeutic drugs, which may facilitate rational design of novel nanomedicines for augmentation of chemotherapy.
Synthesis, characterization, thermal studies, electrochemical behavior, antimicrobial, docking studies, and computational simulation of triazole‐thiol metal complexes
Authors: Fahim Asmaa M. , Magar Hend S. , Ayoub Manara A. 
Published: February 2022

AbstractIn this study, we elucidate the structure and molecular properties of triazole‐thiol derivative (HL) which is confirmed via B3LYP/6‐31G(d) for DFT and HF basis set. Triazole‐thiol (HL) was conjugated with several metal ions to afford stable metal complexes. Consequently, confirmed via intensive physicochemical analysis including FT‐IR spectra, elemental analysis, electronic, 1H‐NMR, TGA, and DTA. The explanation of the thermal cracking of these metal complexes has been estimated. The FT‐IR of these complexes indicated the presence of triazole‐thiol ligand (HL) as chelated coordinated through the N atom of amino group and S atom of SH moiety. Furthermore, Fe(III) complex and Ni(II) adopt octahedral stereochemistry, while the Cu(II) complex is trigonal bipyramidal, and Cd(II) complex is square planar. Thermal investigation maintained the chemical formulation of these metal complexes and exhibited that they decompose in many stages dependent on the kind of ligand and geometry of complexes. Moreover, the HL and metal complexes were exhibited antimicrobial evaluation against bacterial and fungal strains and showed higher activity comparable HL. Additionally, the theoretical docking stimulation of the ligand HL and metal complexes with different proteins showed different in energy affinity with shortage bond length with metal complexes and confirmed the experimental biological results. Eventually, the electrochemical features were explored utilizing cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).
From identifying polymeric resins to corrosion casting applications
Authors: Reyes Pablo , D'hooge Dagmar R. , Cardon Ludwig , Cornillie Pieter 
Published: February 2022

AbstractCorrosion casting is an important manufacturing technique to replicate anatomical structures. Its execution is often based on the injection of resins that can be polymerized starting at room temperature in the presence of an accelerator, which suits most of the practical requirements. In the present contribution, we highlight the main challenges of the corrosion casting technique, addressing a multidisciplinary research angle connecting the fields of life science, veterinary science, materials science, rheology, and polymer reaction engineering. We pay attention to (commercial) material availability, casting medium selection criteria, specimen preparation, maceration, injection possibilities, cleaning procedures, and detail of replication. We start the discussion from general principles and recommendations to then include major examples for each corrosion casting characteristic addressed.