bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Exposure to Organophosphosphorus Pesticide Metabolites compromises mammalian sperm survival, functional and fertility
Authors: Chhillar Shivani , BATRA VIPUL , Kumaresan Arumugam , Kumar Rakesh , Pal Ankit , DATTA TIRTHA 
Published: October 2022

Abstract
Agrichemicals such as metabolites (OPPMs) of the commonly-used organophosphorus pesticides (OPPs) are considered more hazardous and pervasive than their parent pesticides which. This is because parental germline exposure to such xenobiotics has been demonstrated to cause an elevated susceptibility towards various reproductive failures e.g. sub- or in-fertility
Buffalo is a vital livestock resource, however, has numerous reproductive restraints e.g. male subfertility (low conception) that negatively impact its lifetime productivity. This study sought to examine the effects of low-dose, acute OPPM exposure on the mammalian sperm survival and its fertilizing ability. The buffalo spermatozoa were briefly exposed to the three most prevalent organophosphorus pesticides metabolites viz. Omethoate (Dimethoate), paraoxon-methyl (methyl parathion) and 3, 5, 6-trichloro-2-pyridinol, (chlorpyrifos). The structural and functional integrity of the OPPM-exposed and control sperm were evaluated by various Cytomics and Biomimetics experiments including assessment of capacitation, lipid-peroxidation, mitochondrial activity and kinematic parameters (CASA), and in vitro fertilization (IVF) apart from their gene-expression profiling (RT-qPCR).
Preliminary data indicated that a perturbed phosphoproteomic endowment (PTP) and a dysregulated ROS-homeostasis in the OPPM-exposed spermatozoa (P<0.05) negatively affected their fertilizing ability (P<0.01) vis-à-vis control sperm. This is the first study demonstrating the spermatotoxic effects of OPPMs on gamete survival and function.
Evaluation of spatio-seasonal changes of the quality of water through the lower stretch of River Ganga: MCDM tool based approach for water quality indexing
Authors: Sarkar Koushani , Banerjee Gourab , MAZUMDAR ASIS , Majumder Arunabha 
Published: October 2022

Abstract
Knowledge on water quality and its assessment is essential for environmental benefit and human health. The primary focus of the study was to evaluate the spatial and seasonal changes in water quality index (WQI) of Hugli River in West Bengal using Multi Criteria Decision Making (MCDM) tool. Despite of availability of different conventional methods for WQI calculation, present study adheres to the quality index with all sorts of water quality issues in an integrated way. For that MCDM tool such as Analytical Hierarchical Process (AHP) was adopted to determine weights of individual quality parameters and calculation of water quality indices. Nine locations along the stretch of the river were selected depending on population density, agricultural practices, industrial and other activities and ten water quality parameters were considered. According to the results water quality of the whole stretch of the river revealed poor quality of water for drinking and other uses without appropriate treatment though monsoon and autumn showed relatively better quality condition.
Monkeypox virus 2022, gene heterogeneity and protein polymorphism
Authors: Xiong Chenglong , Li Yanjiao , Hou Jingjing , Sun Zhong , Han Wendong , Thilakavathy Karuppiah , Chen Weijie , Wang Yuxi , Liu Xiuliang , Gao Qile , Lu Shuiping , Shao Zhongjun , Lu Yihan , Wang Weibing , Hu Jingjing 
Published: October 2022

Abstract
Human monkeypox (MPX) had been confined to equatorial Africa as an endemic disease1,2. Since early May 2022, cases of human MPX have been explosively reported from countries where the disease is not endemic. This is the first time that many human cases have been reported concurrently in non-endemic and endemic countries in widely disparate geographical areas3,4. Here we analyze 27 genes or sequences from 643 full-length genomes of human monkeypox viruses (MPXVs) established after January 1, 2022. These MPXVs can converge into one branch on the phylogenetic trees of E3L, B13R, B19R, C7L, D11L, N1R, T4, and K4L genes, but can be divided into two, two-plus, or irregular branches on the phylogenetic trees of other genes or sequences. Due to the early appearance of the stop codons, the proteins encoded by D7L, O1L, B5R, B14R, and T4 genes of MPXVs 2022 can be truncated into different lengths, showing polymorphism in length. In particular, MPXVs 2022 had acquired or retained at least two virulent genes (B14R and T4) that do not belong to the ancient West African clade strains. Heterogeneity of genes and polymorphism of proteins may reflect the viruses’ complex epidemic history and the impacts they may suffer from environments, hosts and vectors. These impacts in turn prompt the viruses to frequently acquire, lose, truncate and delete genes. The acquisition or retain virulent genes with functional products of B14R and T4 may affect the virulence and the capacity of human-to-human transmission of MPXVs 2022, and may be responsible for their unprecedented expansions in infected population and epidemic areas.
A novel defined PANoptosis-related miRNA signature for predicting prognosis and immune characteristics in Kidney Renal Clear Cell Carcinoma
Authors: Wang Yanmei , Zhou Jia , Zhang Nan , Zhu Yiran , Zhong Yiming , Wang Zhuo , Jin Hongchuan , Wang Xian 
Published: October 2022

Abstract
Kidney renal clear cell carcinoma (KIRC) is one of the most common malignancies and PANoptosis is a unique inflammatory programmed cell death regulated by the PANoptosome. MicroRNAs (miRNAs) are important regulators of cancer occurrence and progress. However, the potential role of PANoptosis-related miRNAs (PRMs) in KIRC remains elusive. In this study, KIRC samples were collected from The Cancer Genome Atlas database and two Gene Expression Omnibus datasets and PRMs were identified by previous literature reports. Univariate Cox and Lasso Cox regression analyses were applied to identify prognosis PRMs and then construct a PANoptosis-related miRNA prognostic signature evaluated by the risk score. By a variety of R software packages and web analysis tools, we found the high-risk patients bear worse survival prognoses and were significantly associated with high-grade and advanced-stage tumors. Furthermore, we demonstrated the low-risk group had significant changes in metabolic pathways and the high-risk group was characterized by high immune cell infiltration and immune checkpoints expression as well as low IC50 values of chemotherapeutic agents, suggesting that the high-risk patients may benefit more from immunotherapy and chemotherapy. In short, we constructed a PANoptosis-related miRNA signature and revealed its potential significance on the clinicopathological features and tumor immunity, providing new strategies for precise treatment.
The immunolocalization of cluster of differentiation 31, phalloidin and alpha smooth muscle actin on vascular network of normal and ischemic rat brain
Authors: Wang Jia , Guo Yating , Xu Dongsheng , Cui Jingjing , Wang Yuqing , Su Yuxin , Liu Yihan , Shen Yi , Jing Xianghong , Bai Wanzhu 
Published: October 2022

Abstract
Cluster of differentiation 31 (CD31), phalloidin and alpha smooth muscle actin (α-SMA) has been widely applied for labeling the cerebral blood vessels in the past years. CD31 is mainly used as endothelial marker in determining the cerebral capillaries in the past years. However, it seems likely that its labeling efficiency is closely correlated with the antibodies from the polyclonal or monoclonal one, as well as the conditions of blood vessels. In order to test this phenomenon, we firstly compare the labeling characteristics of goat polyclonal anti-CD31 (gP-CD31) and mouse monoclonal anti-CD31 (mM-CD31) on the rat brain in health and ischemic/reperfusion (I/R) with the middle cerebral artery occlusion. By multiple immunofluorescence staining and three-dimensional reconstruction techniques, it was found that gP-CD31 labeling expressed extensively on the cerebral capillaries in the normal and ischemic regions, but mM-CD31 labeling mainly presented on the capillaries in the ischemic region. In contrast to the vascular labeling with phalloidin andα-SMA, gP-CD31 labeling located on the lumen side of vascular wall and surrounded by phalloidin and α-SMA labeling. These results indicate that gP-CD31 is expressed more sensitively than mM-CD31 on the cerebral vasculature, and highly compatible with phalloidin and α-SMA for insight into the cerebral vascular network in a three-dimensional view under the physiological and pathological conditions.
Increased abnormal erythrocytes caused by spleen filtration deficiency provide a hypoxic environment for the occurrence of psoriasis
Authors: Zhao Ya , Wu Yayun , Fan Dancai , Deng Hao , Yao danni , Liu lijuan , deng shigui , zhao ruizhi , lu chuanjian 
Published: October 2022

Abstract
Background
Psoriasis is a chronic autoimmune disease with a long disease course and frequent relapse characteristics, however, its pathogenesis is still not completely clear. Clinical study indicated that blood state is abnormal in psoriasis and seems related with the severity of psoriasis. However, whether this is true and which constituents of blood play the key role and its mechanism behind is not clear.
Methods
Effect of blood constituents on the psoriasis development was determined by comparing serum, red cells, and leukocytes of psoriasis on the onset of psoriasis of NOG mice, using samples of healthy people as the control. The effect of red cell on psoriasis was further demonstrated by splenectomy using Kunming mice. Red cell morphology and spleen histopathology were studied by microscope. IL-6, IL-17A, IL-23, VEGF, IL-22, MDA, NO and HIF were determined by Elisa kits, and q-PCR was used to detect the mRNA of IL-6, IL-22, and IL-23, and western blot was used to detect CD-11b, SPIC, SIPR-α, TSP-1, and CD47.
Results
The hemorheology of psoriatic patients to be abnormal, and aging and deformed erythrocytes increased in the blood. Red cell and leukocyte from psoriasis were more likely to induce psoriasis when comparing with that of from the healthy volunteers, and the effect of red cell was more strong. When splenectomy, mice were also easy to induce psoriasis, demonstrating by the skin lesion, inflammatory factors and histopathology which all similar with psoriasis patients. Psoriasis spleen showed an increased red pulp and white pulp, and increased CD-11b, SPIC, TSP-1 and decreased SPRP-α, CD47 showed marginal change, indicated that the weakening of the “eat me” function of spleen macrophages phagocytizing aging and deformed erythrocytes, resulting in the dysfunction of spleen filtration and the increase of aging and deformed erythrocytes in the body. Additionally, the decreased oxygen-carrying capacity and the declined antioxidant capacity of those erythrocytes led to the hypoxia environment, making psoriasis more likely to be induced.
Conclusion
These findings demonstrate that spleen filtration dysfunction contributes to the pathogenesis of psoriasis and suggest that improving it may be an effective therapy for psoriasis and control its relapse.
Applicability of glycerol dialkyl glycerol tetraethers in China's marginal seas: evidence from surface sediments in the Southern Yellow Sea
Authors: Shao Ming , Zhang Shengyin , Pei Yu , Song Sen , Lei Tianzhu 
Published: October 2022

Abstract
Past climates inform our future. As a good indicator for paleoclimate reconstruction, the applicability of glycerol dialkyl glycerol tetraethers (GDGTs) in high deposition rate areas such as shelf marginal seas needs to be further confirmed. In our study, the distribution of GDGTs in twenty sea surface samples from same longitude (121° 58' 48" E) but different latitude in the South Yellow Sea (SYS) was examined. The result showed that the terrigenous input of the SYS was transported by the Old Yellow River, and high terrestrial input may affect the temperature reconstruction. The sea surface temperature may be controlled by the Yellow Sea Warm Current (YSWC) in the SYS, followed by the changes of latitude and the distance from coast. This study proves that GDGTs-related indicators still have good applicability in marginal seas with complex environments and diverse sources.
Many-body reduced vector solution and water vibrations
Authors: Abdel-Rahman A. S. 
Published: October 2022

Abstract
Reduced mass value and vector are well known for the two-body problem, but the many-body reduced vector problem is not solved yet. The study of many-body problems and their applications (such as vibrational spectroscopy) is one of the more important physical problems. Vibrational spectroscopy provides a powerful tool to perceive the molecular structures and atom motions of molecules. The water molecule is a three-body system stretching vibration that has been previously quantized; their frequencies were defined and showed the infrared (IR) absorption spectrum based on Morse potential. In this work, the reduced mass of the many-body problem is being solved and then used to study the intensity of the stretching vibration modes and show the ratio is in agreement with experiments. The molecule was studied in classical and quantum mechanics to determine its absorption intensity as an example of a reduced mass problem. The results show molecular atomic motions and changes in dipole and reduced mass vector. A Morse-like model for bending was predicted based on the spectroscopic vibration frequency and intensity, defining the bending potential depth of 93.5 kJ/mol.
Ecosystem Understanding of the City-Human Being Relationship
Authors: Najder-Stefaniak Krystyna 
Published: October 2022

This paper presents the ecosystem understanding of the city-human being relationship. The author makes use of the paradigm of the ecosystem relationship in order to understand the city and human being as elements of the cultural and natural system. The concept of the ecosystem relationship, as defined by Edgar Morin, the French theoretician of complexity, plays an important role here. The paradigm of the ecosystem relationship makes us realize the complexity of dependencies in the dynamic, open and relatively isolated system of activity. Morin was inspired by Erwin Schrödinger’s discovery that the ecosystem co-organizes and takes part in the programming of the organisms within it. The social and natural system is the second crucial notion in this paper. It was coined as a result of interdisciplinary research conducted by Józef Marceli Dołęga, the founder of the Polish school of humanistic ecology and systemic sozology. The concept of transgression is yet another one important in my work. The term “transgressive man” was coined by Józef Kozielecki, a psychologist. Having understood transgression, we may see that man is capable of bestowing his presence on the present, future and past. The paradigm of the ecosystem relationship allows us to understand that a subject may direct its actions not only toward what is but also toward what may or should be. The conclusion is that we, as elements of the cultural and natural ecosystem, may enrich the city when we become part of it. Moreover, we may enrich ourselves when the city becomes part of our space.
Investigating the Provision and Context of Use of Hearing Aid Listening Programs From Real-world Data: Observational Study
Authors: Pasta Alessandro , Szatmari Tiberiu-Ioan , Christensen Jeppe Høy , Jensen Kasper Juul , Pontoppidan Niels Henrik , Sun Kang , Larsen Jakob Eg 
Published: October 2022

Background
Listening programs enable hearing aid (HA) users to change device settings for specific listening situations and thereby personalize their listening experience. However, investigations into real-world use of such listening programs to support clinical decisions and evaluate the success of HA treatment are lacking.

Objective
We aimed to investigate the provision of listening programs among a large group of in-market HA users and the context in which the programs are typically used.

Methods
First, we analyzed how many and which programs were provided to 32,336 in-market HA users. Second, we explored 332,271 program selections from 1312 selected users to investigate the sound environments in which specific programs were used and whether such environments reflect the listening intent conveyed by the name of the used program. Our analysis was based on real-world longitudinal data logged by smartphone-connected HAs.

Results
In our sample, 57.71% (18,663/32,336) of the HA users had programs for specific listening situations, which is a higher proportion than previously reported, most likely because of the inclusion criteria. On the basis of association rule mining, we identified a primary additional listening program, Speech in Noise, which is frequent among users and often provided when other additional programs are also provided. We also identified 2 secondary additional programs (Comfort and Music), which are frequent among users who get ≥3 programs and usually provided in combination with Speech in Noise. In addition, 2 programs (TV and Remote Mic) were related to the use of external accessories and not found to be associated with other programs. On average, users selected Speech in Noise, Comfort, and Music in louder, noisier, and less-modulated (all P<.01) environments compared with the environment in which they selected the default program, General. The difference from the sound environment in which they selected General was significantly larger in the minutes following program selection than in the minutes preceding it.

Conclusions
This study provides a deeper insight into the provision of listening programs on a large scale and demonstrates that additional listening programs are used as intended and according to the sound environment conveyed by the program name.
Development of an mHealth App–Based Intervention for Depressive Rumination (RuminAid): Mixed Methods Focus Group Evaluation
Authors: Rosenfeld Eve A , Lyman Cassondra , Roberts John E 
Published: October 2022

Background
Depression is a common mental health condition that poses a significant public health burden. Effective treatments for depression exist; however, access to evidence-based care remains limited. Mobile health (mHealth) apps offer an avenue for improving access. However, few mHealth apps are informed by evidence-based treatments and even fewer are empirically evaluated before dissemination. To address this gap, we developed RuminAid, an mHealth app that uses evidence-based treatment components to reduce depression by targeting a single key depressogenic process—rumination.

Objective
The primary objective of this study was to collect qualitative and quantitative feedback that could be used to improve the design of RuminAid before the software development phase.

Methods
We reviewed empirically supported interventions for depression and rumination and used the key aspects of each to create a storyboard version of RuminAid. We distributed an audio-guided presentation of the RuminAid storyboard to 22 individuals for viewing and solicited user feedback on app content, design, and perceived functionality across 7 focus group sessions.

Results
The consumer-rated quality of the storyboard version of RuminAid was in the acceptable to good range. Indeed, most participants reported that they thought RuminAid would be an engaging, functional, and informational app. Likewise, they endorsed overwhelming positive beliefs about the perceived impact of RuminAid; specifically, 96% (21/22) believed that RuminAid will help depressed ruminators with depression and rumination. Nevertheless, the results highlighted the need for improved app aesthetics (eg, a more appealing color scheme and modern design).

Conclusions
Focus group members reported that the quality of information was quite good and had the potential to help adults who struggle with depression and rumination but expressed concern that poor aesthetics would interfere with users’ desire to continue using the app. To address these comments, we hired a graphic designer and redesigned each screen to improve visual appeal. We also removed time gating from the app based on participant feedback and findings from related research. These changes helped elevate RuminAid and informed its initial software build for a pilot trial that focused on evaluating its feasibility and acceptability.
GRUPOS DE PESQUISA INTERINSTITUCIONAIS
Authors: Schneider Cintia , Costa David Antonio da , Hoffmann Yohana Taise 
Published: October 2022

O objetivo principal deste trabalho é realizar entrelaçamentos entre as práticas de investigação de grupos de pesquisa interinstitucionais, em especial o caso do Grupo de Pesquisa em História da Educação Matemática do Brasil (GHEMAT), e os conceitos de circulação intracoletiva e intercoletiva, círculo exotérico e esotérico tomados dos estudos de Fleck (2010). Uma busca no Diretório de Grupos de Pesquisa do CNPq no campo da História da educação matemática (Hem) resultou em oito grupos interinstitucionais. Dentre estes, destaca-se o GHEMAT que possui vínculo com 24 distintas instituições parceiras. Constatou-se que este promove a circulação intra e intercoletiva por meio de grupos de trabalho nos eventos próprios e da área da educação, impulsiona a circulação de dossiês e artigos em revistas do campo da Hem, implementa disciplinas com a sua perspectiva teórica e metodológica nos diversos espaços institucionais e, desta forma, fortalece o círculo esotérico, o que favorece a expansão das pesquisas na área.
Economic patriotism among people under 35 in Poland in the face of globalization
Authors: Śliwa Mateusz 
Published: October 2022

Motivation: Nowadays, economic patriotism is the current social trend affecting a number of aspects related to the economy, the functioning of enterprises and consumers in the conditions of market competition. Companies wishing to maximize their profits and at the same time remain in positive relationships with their customers should pay special attention to the factors that determine the decision-making of young consumers in the selection of goods and services.
Aim: The study pays special attention to current situations related to the internationalization of enterprises operating on the Polish market. The main aim of the analysis is to show a number of determinants influencing the manifestations of economic patriotism among adults up to 35 years of age, which if well understood, will allow entrepreneurs to increase the effectiveness of their managed institutions, as well as the analysis of positive and negative market behavior related to economic patriotism.
Materials and methods: For the purpose of this study, own research was conducted, which brings a new approach to the discussed issue, showing the attitudes of young consumers consistent with the idea of economic patriotism.
Results: People under the age of 35 show a high awareness of economic patriotism and are consumers with a high degree of ethnocentrism. For further effective development of attitudes related to economic patriotism and, above all, their practical realization, a broad initiative is necessary from top-down undertakings on the part of the government, through schools and universities to grassroots social initiatives and realization of the idea of economic patriotism by the individual.