bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alat Penentu Ukuran dan Stok Sepatu Otomatis Berbasis IoT (Internet of Things) Menggunakan ESP32
Authors: Aryasatya Waluyo Muhammad Titan , Siswoko Siswoko , Subiyantoro Subiyantoro 
Published: August 2022

[1] A. Hermawan, A. Muid, I. Nirmala, “Rancang Bangun Alat Ukur Panjang Kaki dan Penentu Stok Sepatu yang Tersedia Secara Digital Menggunakan Arduino Mega 2560 Berbasis Website”. Kumpulan Jurnal Ilmu Komputer (KLIK). Vol. 05, No. 02. September 2018.[2] R. Firdaus, M.F. Wicaksono. M. Kom. “Alat Pengukur Ukuran Kaki untuk Pencarian Sepatu Berbasis Raspberry Pi”, Jurnal UNIKOM. 2018.[3] M. Subiatno, H. Setiawan, dkk, “Rancang Bangun Prototipe Sistem Kontrol Penggunaan Air Prabayar Berbasis Arduino Uno”, STIKI Informatika Jurnal ,Vol. 8, No. 1, April 2018.[4] Muliadi. Al Imran. Muh. Rasul. Pengenmbangan Tempat Sampah Pintar Menggunakan ESP32, Jurnal Media Elektrik Vol.17 No.2, April 2020.[5] Arasada, Bakhtiyar. Suprianto, Bambang. Aplikasi Sensor Ultrasonik Untuk Deteksi Posisi Jarak Pada Ruang Menggunakan Arduino Uno. Jurnal Teknik Elektro. Vol.6, No. 2. 2017.[6] A. Prayitno, dkk. “Pengaruh Brand Image, Lifestyle dan Promosi Terhadap Keputusan Pembelian Sepatu Ventela (Studi Kasus pada Konsumen Toko Gorilla Market Bululawang)”, E-Journal Manajemen Prodi Manajemen Fakultas Ekonomi dan Bisnis Unisma. Vol 10. No 15. 2021.[7] K. Koloay, dkk. “Rancang Bangun Aplikasi Fitness Berbasis Android (Studi Kasus: Popeye Gym Suwaan)”, E-Journal Teknik Informatika Vol.5, No. 2. 2020.[8] S. Surahman, dan E.B. Setiawan, “Aplikasi Mobile Driver Online Berbasis Android Untuk Perusahaan Rental Kendaraan”, Jurnal ULTIMA InfoSys. Vol. VIII, No.1. Juni 2017.[9] G. H. Krisnawati, “Membangun Aplikasi Berbasis Android “Pembelajaraan Menggunakan APP Inventor”, Jurnal DASI. Vol.12, No.4. Desember 2011.[10] Sunardi, dkk. “Analisis Application Programming Interface pada Mobile E-Voting menggunakan Metode Test-Driven Development, Jurnal TECHNO. Vol, 20. No.2. Oktober 2019.[11] I. F. Maulana, “Penerapan Firebase Real Time Database pada Aplikasi E-Tilang Smartphone Berbasis Mobile Android”, Jurnal RESTI. Vol.4 No. 5. 2020.
Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs
Authors: Lee Miyoung , Geitgey Delaney K. , Hamilton Jamie A. G. , Boss Jeremy M. , Scharer Christopher D. , Spangle Jennifer M. , Haynes Karmella A. , Henry Curtis J. 
Published: August 2022

The world’s population with obesity is reaching pandemic levels. If current trends continue, it is predicted that there will be 1.5 billion people with obesity by 2030. This projection is alarming due to the association of obesity with numerous diseases including cancer, with recent studies demonstrating a positive association with acute myeloid leukemia (AML) and B cell acute lymphoblastic leukemia (B-ALL). Interestingly, several epidemiological studies suggest the converse relationship may exist in patients with T cell acute lymphoblastic leukemia (T-ALL). To determine the relationship between obesity and T-ALL development, we employed the diet-induced obesity (DIO) murine model and cultured human T-ALL cells in adipocyte-conditioned media (ACM), bone marrow stromal cell-conditioned media, stromal conditioned media (SCM), and unconditioned media to determine the functional impact of increased adiposity on leukemia progression. Whereas only 20% of lean mice transplanted with T-ALL cells survived longer than 3 months post-inoculation, 50%–80% of obese mice with leukemia survived over this same period. Furthermore, culturing human T-ALL cells in ACM resulted in increased histone H3 acetylation (K9/K14/K18/K23/K27) and methylation (K4me3 and K27me3) posttranslational modifications (PTMs), which preceded accelerated cell cycle progression, DNA damage, and cell death. Adipocyte-mediated epigenetic changes in human T-ALL cells were recapitulated with the H3K27 demethylase inhibitor GSK-J4 and the pan-HDAC inhibitor vorinostat. These drugs were also highly cytotoxic to human T-ALL cells at low micromolar concentrations. In summary, our data support epidemiological studies demonstrating that adiposity suppresses T-ALL pathogenesis. We present data demonstrating that T-ALL cell death in adipose-rich microenvironments is induced by epigenetic modifications, which are not tolerated by leukemia cells. Similarly, GSK-J4 and vorinostat treatment induced epigenomic instability and cytotoxicity profiles that phenocopied the responses of human T-ALL cells to ACM, which provides additional support for the use of epigenetic modifying drugs as a treatment option for T-ALL.
Clinical and genetic characteristics of 29 Chinese patients with X-linked hypophosphatemia
Authors: Xu Tian , Tao Xiaohui , Zhang Zhenlin , Yue Hua 
Published: August 2022

ObjectiveThe aim of this study was to fully describe the clinical and genetic characteristics, including clinical manifestations, intact fibroblast growth factor 23 (iFGF23) levels, and presence of PHEX gene mutations, of 22 and 7 patients with familial and sporadic X-linked dominant hypophosphatemia (XLH), respectively.MethodsDemographic data, clinical features, biochemical indicators, and imaging data of 29 patients were collected. All 22 exons and exon–intron boundaries of the PHEX gene were amplified by polymerase chain reaction (PCR) and directly sequenced. The serum level of iFGF23 was measured in 15 of the patients.ResultsTwenty-nine patients (male/female: 13:16, juvenile/adult: 15:14) with XLH were included. The main symptoms were bowed lower extremities (89.7%), abnormal gait (89.7%), and short stature/growth retardation (78.6%). Hypophosphatemia with a high alkaline phosphatase level was the main biochemical feature and the median value of serum iFGF23 was 55.7 pg/ml (reference range: 16.1–42.2 pg/ml). Eight novel mutations in the PHEX gene were identified by Sanger sequencing, including two missense mutations (p. Gln682Leu and p. Phe312Ser), two deletions (c.350_356del and c.755_761del), one insertion (c.1985_1986insTGAC), and three splice mutations (c.1700+5G&gt;C, c.1966-1G&gt;T, and c.350-14_350-1del). Additionally, the recurrence rate after the first orthopedic surgery was 77.8% (7/9), and five of them had their first surgery before puberty.ConclusionOur study expanded the clinical phenotypes and gene mutation spectrum of XLH and provided a reference for the optimal timing of orthopedic surgeries.
High-resolution estimation of air pollutant emissions from vegetation burning in China (2000–2018)
Authors: Yang Wei , Jiang Xiaoli 
Published: August 2022

Vegetation burning in China contributes significantly to atmospheric pollution and climate change. However, most recent studies have focused on forest fires, ignoring grassland fires. Besides, there was a generally high uncertainty in the estimated fire emission because of missing small fire data and limited local vegetation data. This study employed high-resolution burned area data (GABAM, global annual burned area map) and land cover data to develop a high-resolution (30 m) emission inventory of vegetation burning in China in 2000, 2005, 2010, 2015, and 2018. Eleven pollutants were estimated, including CO, CH4, NOx, non-methane volatile organic carbon (NMVOC), SO2, NH3, PM2.5, PM10, organic carbon (OC), black carbon (BC), and CO2. The cumulative pollutant emissions from the temporal and spatial variation analyses of the burned area and emissions reached 1.21 × 105 Gg. Specifically, CO2 was the largest emission, with a mean annual emission of 2.25 × 104 Gg, accounting for 92.46% of the total emissions. CO was the second-largest emission, with a mean annual emission of 1.13 × 103 Gg. PM10 and PM2.5 emissions were also relatively high, with a mean annual emission of 200.5 and 140.3 Gg, respectively, with that of NMVOC (159.24 Gg) in between. The emissions of other pollutants, including OC, NOx, CH4, NH3, SO2, and BC, were relatively low. The South, Southwest, East, and Northeast of China contributed the most emissions. Shrubland contributed the most emissions for different vegetation types, followed by forest and grassland. Consequently, this study provides scientific evidence to support understanding the influence of fire on the local environment and policy on China’s air pollution control.
Maize diversification and nitrogen fertilization effects on soil nitrous oxide emissions in irrigated mediterranean conditions
Authors: Franco-Luesma Samuel , Lafuente Victoria , Alonso-Ayuso María , Bielsa Ana , Kouchami-Sardoo Iraj , Arrúe José Luis , Álvaro-Fuentes Jorge 
Published: August 2022

Maize is a major irrigated crop in Mediterranean areas and its typical intensive management may impact soil nitrous oxide (N2O) emissions. In these irrigated continuous maize systems, the legumes incorporation as well as adjusted nitrogen (N) fertilization might be interesting strategies to reduce soil N2O emissions. The objective of this study was to assess the impact of cropping diversification and different N rates on soil N2O emissions in flooded irrigated maize under Mediterranean conditions. To achieve this, two cropping systems (maize monoculture system, MC; and pea -maize rotation, MP) and 3N rates (unfertilized, 0N; medium rate, MN; and high rate, HN) were evaluated in a field experiment established in NE Spain during 2 years (2019; 2020). During the studied period, the N rate had a significant effect on soil N2O emissions, with a non-linear positive response of cumulative soil N2O emissions to N rates. In both systems, quick and high increases of soil N2O fluxes were observed immediately after the N application reaching 55 and 100 mg N2O-N m−2 day−1 in MC and MP, respectively. Both years, the pea phase of the MP rotation showed greater cumulative N2O emissions than the fallow of MC. However, N2O losses in the maize phase were similar (2019) or even higher (2020) in MC than in MP. Moreover, in both seasons, the MN treatments showed lower yield-scaled N2O emissions and N emission factor than the HN treatments, being this last lower than 1% in all cases. The results obtained showed that in irrigated Mediterranean conditions the replacement of a fallow by a legume, together with an adjusted N fertilization are favourable strategies to mitigate soil N2O emissions in high-yielding maize systems.
Estimating the energy saving potential of residential consumption in China based on decent living standards
Authors: Yu Yawen , Yang Jin , Chai Song , Tang Lin 
Published: August 2022

The basic well-being of residents should be fully considered when making residential energy-saving policies. In this study, decent living standards for China were proposed. The provincial energy saving potential of Chinese residents were estimated from a lifetime perspective using environmental extended input–output analysis. The results show that, in 2017, the energy saving potential of Chinese residents constituted 32.74% of total energy consumption. The consumption categories of transportation, housing and cooking had the greatest energy saving potential of 1668.40, 3540.83 and 3229.75 trillion kJ, respectively, in which direct energy consumption accounted for 85% of total energy consumption. For food, clothing, water, health care and education, there was only energy saving potential from indirect consumption, of which food has the largest indirect energy consumption of 3159.25 trillion kJ. Moreover, the energy saving potential varied at the provincial level, coming from different consumption categories. Special attentions should be paid to the transportation in Beijing, housing in Liaoning, and cooking in Gansu, which have relatively greater energy saving potential with per capita energy saving potential of 207.38, 1002.16, and 4256.6 thousand kJ, respectively. The results verify the importance of differentiated and targeted energy policies for residential consumption in different provinces.
EV duty vehicles: Features and functions of ciliary extracellular vesicles
Authors: Vinay Ludovic , Belleannée Clémence 
Published: August 2022

The primary cilium is a microtubule-based organelle that extends from a basal body at the surface of most cells. This antenna is an efficient sensor of the cell micro-environment and is instrumental to the proper development and homeostatic control of organs. Recent compelling studies indicate that, in addition to its role as a sensor, the primary cilium also emits signals through the release of bioactive extracellular vesicles (EVs). While some primary-cilium derived EVs are released through an actin-dependent ectocytosis and are called ectosomes (or large EVs, 350–500 nm), others originate from the exocytosis of multivesicular bodies and are smaller (small EVs, 50–100 nm). Ciliary EVs carry unique signaling factors, including protein markers and microRNAs (miRNAs), and participate in intercellular communication in different organism models. This review discusses the mechanism of release, the molecular features, and functions of EVs deriving from cilia, based on the existing literature.
Prenatal phenotype analysis and mutation identification of a fetus with meckel gruber syndrome
Authors: Moreno-Leon Laura , Quezada-Ramirez Marco A. , Bilsbury Evan , Kiss Courtney , Guerin Andrea , Khanna Hemant 
Published: August 2022

Ciliopathies are a class of inherited severe human disorders that occur due to defective formation or function of cilia. The RPGRIP1L (retinitis pigmentosa GTPase regulator-interacting protein1-like) gene encodes for a ciliary protein involved in regulating cilia formation and function. Mutations in RPGRIP1L cause ciliopathies associated with severe embryonic defects, such as Meckel-Gruber Syndrome (MKS). Here we report RPGRIP1L mutation analysis in a family diagnosed with MKS. The clinical manifestations of the fetus included thoraco-lumbar open neural tube defect with associated Chiari type II malformation and hydrocephalus, bilateral club feet, and single right kidney/ureter. Analysis of the parental DNA samples revealed that the father carried a previously reported mutation R1236C/+ whereas the mother had a novel splice site mutation IVS6+1 G &gt; A/+ in RPGRIP1L. The splice site mutation resulted in the exclusion of in-frame exon 6 of RPGRIP1L (RPGRIP1L-∆Ex6) but expressed a stable protein in fibroblasts derived from the parents’ skin biopsies. The GFP-RPGRIP1L-∆Ex6 mutant protein exhibited relatively reduced ciliary localization in transiently-transfected cultured RPE-1 cells. Taken together, this study identifies a novel RPGRIP1L variant RPGRIP1L-∆Ex6, which in combination with RPGRIP1L-R1236C is associated with MKS. We also suggest that the deletion of exon 6 of RPGRIP1L leads to reduced ciliary localization of RPGRIP1L, indicating a plausible mechanism of associated disease.
Efficacy and safety of biological agents for the treatment of pediatric patients with psoriasis: A bayesian analysis of six high-quality randomized controlled trials
Authors: Cai Xiao-ce , Ru Yi , Liu Liu , Sun Xiao-ying , Zhou Ya-qiong , Luo Ying , Chen Jia-le , Zhang Miao , Wang Chun-xiao , Li Bin , Li Xin 
Published: August 2022

BackgroundBiological agents have been used with extreme caution in children because of their possible adverse effects.ObjectivesThis study used high-quality randomized controlled trials (RCTs) to provide high-level evidence to assess the effectiveness and safety of biological agents for treating children with psoriasis.MethodsWe searched PubMed, Embase, Cochrane, and Web of Science databases through October 31, 2021. We included trials reporting at least one adverse event after treatment with biological agents of patients less than 18-year-old diagnosed with psoriasis. RevMan 5.3 and Stata 15.0 software were used for meta and Bayesian analyses.ResultsSix trials with 864 participants were included in the analysis. The results showed a 2.37-fold higher response rate in all biologics groups than in the control group for psoriasis area and severity index 75 (PASI75) (RR= 2.37, P-value &lt; 0.01, 95% confidence interval [CI] [1.22, 4.62]). Compared with placebo, the PASI75 response rates of etanercept (RR= 2.82, 95% [CI] [1.10, 7.21]), ustekinumab low dose (RR= 7.45, 95%[CI] [1.25, 44.58]), and ustekinumab high dose (RR= 7.25, 95%[CI] [1.21, 43.41]) were superior. Additionally, the incidence of total adverse reactions was 1.05 times higher for biologics than for controls, indicating a good safety profile (RR= 1.05, P-value = 0.53, 95%[CI] [0.92, 1.19]). Overall, these six high-quality randomized controlled trials suggest that biologics are effective and safe for pediatric patients with psoriasis.LimitationsInclusion of few relevant, high-quality RCTs.ConclusionThe results of this study indicate that biologics can be used to treat children with moderate-to-severe psoriasis without the risk of adverse effects. Ustekinumab showed the best efficacy and the fewest adverse effects.
Drug-induced Fanconi syndrome in patients with kidney allograft transplantation
Authors: Tang Zhouqi , Li Tengfang , Dai Helong , Feng Chen , Xie Xubiao , Peng Fenghua , Lan Gongbin , Yu Shaojie , Wang Yu , Fang Chunhua , Nie Manhua , Yuan Xiaoqiong , Tang Xiaotian , Jiang Xin , Zhu Xuejing , Fan Yuxi , Peng Jiawei , Sun Siyu , Zhong Mingda , Zhang Hedong , Peng Longkai 
Published: August 2022

BackgroundPatients after kidney transplantation need to take long-term immunosuppressive and other drugs. Some of these drug side effects are easily confused with the symptoms of Fanconi syndrome, resulting in misdiagnosis and missed diagnosis, and causing serious consequences to patients. Therefore, improving awareness, early diagnosis and treatment of Fanconi syndrome after kidney transplantation is critical.MethodsThis retrospective study analyzed 1728 cases of allogeneic kidney transplant patients admitted to the Second Xiangya Hospital of Central South University from July 2016 to January 2021. Two patients with Fanconi syndrome secondary to drugs, adefovir dipivoxil (ADV) and tacrolimus, were screened. We summarized the diagnostic process, clinical data, and prognosis.ResultsThe onset of Fanconi syndrome secondary to ADV after renal transplantation was insidious, and the condition developed after long-term medication (&gt;10 years). It mainly manifested as bone pain, osteomalacia, and scoliosis in the late stage and was accompanied by obvious proximal renal tubular damage (severe hypophosphatemia, hypokalemia, hypocalcemia, hypouricemia, glycosuria, protein urine, acidosis, etc.) and renal function damage (increased creatinine and azotemia). The pathological findings included mitochondrial swelling and deformity in renal tubular epithelial cells. The above symptoms and signs were relieved after drug withdrawal, but the scoliosis was difficult to rectify. Fanconi syndrome secondary to tacrolimus has a single manifestation, increased creatinine, which can be easily confused with tacrolimus nephrotoxicity. However, it is often ineffective to reduce the dose of tacrolomus, and proximal renal failure can be found in the later stage of disease development. There was no abnormality in the bone metabolism index and imageological examination findings. The creatinine level decreased rapidly, the proximal renal tubule function returned to normal, and no severe electrolyte imbalance or urinary component loss occurred when the immunosuppression was changed from tacrolimus to cyclosporine A.ConclusionsFor the first time, drug-induced Fanconi syndrome after kidney transplantation was reported. These results confirmed that the long-term use of ADV or tacrolimus after kidney transplantation may have serious consequences, some of which are irreversible. Greater understanding of Fanconi syndrome after kidney transplantation is necessary in order to avoid incorrect and missed diagnosis.
Concomitant spine trauma in patients with traumatic brain injury: Patient characteristics and outcomes
Authors: Riemann Lennart , Alhalabi Obada T. , Unterberg Andreas W. , Younsi Alexander ,   The CENTER-TBI investigators and participants
Published: August 2022

ObjectiveSpine injury is highly prevalent in patients with poly-trauma, but data on the co-occurrence of spine trauma in patients with traumatic brain injury (TBI) are scarce. In this study, we used the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) database to assess the prevalence, characteristics, and outcomes of patients with TBI and a concurrent traumatic spinal injury (TSI).MethodsData from the European multi-center CENTER-TBI study were analyzed. Adult patients with TBI (≥18 years) presenting with a concomitant, isolated TSI of at least serious severity (Abbreviated Injury Scale; AIS ≥3) were included. For outcome analysis, comparison groups of TBI patients with TSI and systemic injuries (non-isolated TSI) and without TSI were created using propensity score matching. Rates of mortality, unfavorable outcomes (Glasgow Outcome Scale Extended; GOSe &lt; 5), and full recovery (GOSe 7–8) of all patients and separately for patients with only mild TBI (mTBI) were compared between groups at 6-month follow-up.ResultsA total of 164 (4%) of the 4,254 CENTER-TBI core study patients suffered from a concomitant isolated TSI. The median age was 53 [interquartile range (IQR): 37–66] years and 71% of patients were men. mTBI was documented in 62% of cases, followed by severe TBI (26%), and spine injuries were mostly cervical (63%) or thoracic (31%). Surgical spine stabilization was performed in 19% of cases and 57% of patients were admitted to the ICU. Mortality at 6 months was 11% and only 36% of patients regained full recovery. There were no significant differences in the 6-month rates of mortality, unfavorable outcomes, or full recovery between TBI patients with and without concomitant isolated TSI. However, concomitant non-isolated TSI was associated with an unfavorable outcome and a higher mortality. In patients with mTBI, a negative association with full recovery could be observed for both concomitant isolated and non-isolated TSI.ConclusionRates of mortality, unfavorable outcomes, and full recovery in TBI patients with and without concomitant, isolated TSIs were comparable after 6 months. However, in patients with mTBI, concomitant TSI was a negative predictor for a full recovery. These findings might indicate that patients with moderate to severe TBI do not necessarily exhibit worse outcomes when having a concomitant TSI, whereas patients with mTBI might be more affected.