bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease
Authors: Bleakley Marie , Sehgal Alison , Seropian Stuart , Biernacki Melinda A. , Krakow Elizabeth F. , Dahlberg Ann , Persinger Heather , Hilzinger Barbara , Martin Paul J. , Carpenter Paul A. , Flowers Mary E. , Voutsinas Jenna , Gooley Theodore A. , Loeb Keith , Wood Brent L. , Heimfeld Shelly , Riddell Stanley R. , Shlomchik Warren D. 
Published: January 2022

PURPOSE Graft-versus-host disease (GVHD) causes morbidity and mortality following allogeneic hematopoietic cell transplantation. Naive T cells (TN) cause severe GVHD in murine models. We evaluated chronic GVHD (cGVHD) and other outcomes in three phase II clinical trials of TN-depletion of peripheral blood stem-cell (PBSC) grafts. METHODS One hundred thirty-eight patients with acute leukemia received TN-depleted PBSC from HLA-matched related or unrelated donors following conditioning with high- or intermediate-dose total-body irradiation and chemotherapy. GVHD prophylaxis was with tacrolimus, with or without methotrexate or mycophenolate mofetil. Subjects received CD34-selected PBSC and a defined dose of memory T cells depleted of TN. Median follow-up was 4 years. The primary outcome of the analysis of cumulative data from the three trials was cGVHD. RESULTS cGVHD was very infrequent and mild (3-year cumulative incidence total, 7% [95% CI, 2 to 11]; moderate, 1% [95% CI, 0 to 2]; severe, 0%). Grade III and IV acute GVHD (aGVHD) occurred in 4% (95% CI, 1 to 8) and 0%, respectively. The cumulative incidence of grade II aGVHD, which was mostly stage 1 upper gastrointestinal GVHD, was 71% (95% CI, 64 to 79). Recipients of matched related donor and matched unrelated donor grafts had similar rates of grade III aGVHD (5% [95% CI, 0 to 9] and 4% [95% CI, 0 to 9]) and cGVHD (7% [95% CI, 2 to 13] and 6% [95% CI, 0 to 12]). Overall survival, cGVHD-free, relapse-free survival, relapse, and nonrelapse mortality were, respectively, 77% (95% CI, 71 to 85), 68% (95% CI, 61 to 76), 23% (95% CI, 16 to 30), and 8% (95% CI, 3 to 13) at 3 years. CONCLUSION Depletion of TN from PBSC allografts results in very low incidences of severe acute and any cGVHD, without apparent excess risks of relapse or nonrelapse mortality, distinguishing this novel graft engineering strategy from other hematopoietic cell transplantation approaches.
MRI findings suggestive of Alzheimer’s disease in patients with primary open angle glaucoma – a single sequence analysis using rapid 3D T1 spoiled gradient echo
Authors: Hanafiah Mohammad , Johari Bushra , Ab Mumin Nazimah , Musa Azlan Azha , Hanafiah Hazlenah 
Published: January 2022

Objective: Primary open-angle glaucoma (POAG) is a degenerative optic neuropathy disease which has somewhat similar pathophysiology to Alzheimer’s disease (AD). This study aims to determine the presence of medial temporal atrophy and parietal lobe atrophy in patients with POAG compared to normal controls using medial temporal atrophy (MTA) scoring and posterior cortical atrophy (PCA) scoring system on T1 magnetization-prepared rapid gradient-echo. Methods: 50 POAG patients and 50 normal subjects were recruited and an MRI brain with T1-magnetization-prepared rapid gradient-echo was performed. Medial temporal lobe and parietal lobe atrophy were by MTA and PCA/Koedam scoring. The score of the PCA and MTA were compared between the POAG group and the controls. Results: There was a significant statistical difference between PCA score in POAG and the healthy control group (p-value = 0.026). There is no statistical difference between MTA score in POAG compared to the healthy control group (p-value = 0.58). Conclusion: This study suggests a correlation between POAG and PCA score. Potential application of this scoring method in clinical diagnosis and monitoring of POAG patients. Advances in knowledge: The scoring method used in AD may also be applied in the diagnosis and monitoring of POAG MRI brain, specifically rapid volumetric T1 spoiled gradient echo sequence, may be applied in POAG assessment.
Digital Transformation of Adaptation and Personnel Involvement Management After the Global Pandemic
Authors: Maslennikov I. 
Published: January 2022

The problem that is described in the article has become one of the most crucial and important during first pandemic months of 2020. All new working conditions were a tough challenge for companies that should change all their process to keep the business alive. But even in that crisis times companies have to hire the new personnel and especially crucial not only hire but to adapt people to work both in new company and new remote or partly remote conditions.
In this article the manager’s adaptation and involvement management process is reviewed from the point of view of restricted communication methods. The implementation of project management theory approach is described as a tool that could improve and secure the adaptation aspect of human resource management.
Management by Development of Innovative Potential of Organization
Authors: Borisov A. , Shelonaev S. , Trofimova T. , Rasina M. 
Published: January 2022

This article explores the innovation potential of the staff at industrial enterprises. The relevance of the research is confirmed by the increasing interest of companies in innovation. This manifests itself both in the changing organizational structure of enterprises and a new approach to human resource management, for instance, the revision of the key performance indicators of employees.
One of the main goals of the research was determining the factors that influence the development of the innovation potential of staff and assessment of their impact.
The institutional approach formed the conceptual basis of the study. It allowed the authors to consider the management of innovation potential as a special mechanism for achieving sustainability, stable development of an enterprise, and its strategic success in general.
The authors established that organizational and administrative factors have the greatest influence on the formation and development of the innovation potential of staff, while the constraining factors are the lack of an innovative strategy, authoritarian management style, and bureaucratization.
Studying the techniques aimed at the development of staff’s innovation potential, the authors concluded that the most effective ones for industrial enterprises are consultations of subject matter specialists.
A significant novelty of this work is the model of interaction of participants in the innovation process developed by the authors.
The research findings enabled the authors to devise recommendations for the formation and development of the innovation potential of the company’s employees.
Kwestia lokalizacji siedziby (konwentu) komturów ziemi chełmińskiej w XIII– pierwszych dekadach XIV wieku
Authors: Szczupak Dominika 
Published: January 2022

W artykule podjęto próbę wskazania lokalizacji i scharakteryzowania formy architektonicznej siedzib komturów ziemi chełmińskiej. Rozważania na ten temat przeprowadzono na podstawie analizy źródeł historycznych, weryfikacji dotychczasowych poglądów oraz wyników badań archeologicznych.
Stan i potrzeby badań nad osadą wczesnośredniowieczną w Biskupinie (stanowisko 6)
Authors: Zawol Magdalena 
Published: January 2022

Artykuł dotyczy aktualnego stanu wiedzy na temat wczesnośredniowiecznej osady zarejestrowanej na stanowisku 6 w Biskupinie. Opiera się on głównie na wynikach badań stacjonarnych prowadzonych w latach 1949–1954, ujętych w monografii Włodzimierza i Zoji Szafrańskich. Wyniki te wymagają weryfikacji i aktualizacji, a materiał źródłowy ponownej analizy.
Polsko-czeskie i czesko-polskie kontakty w toruńskiej archeologii w drugiej połowie XX wieku
Authors: Małecka-Kukawka Jolanta 
Published: January 2022

Archeologia w Toruniu instytucjonalnie istnieje od ponad 160 lat. Jednak o kontaktach polsko-czeskich i czesko-polskich można mówić dopiero od okresu po drugiej wojnie światowej, kiedy na nowo powstałym Uniwersytecie Mikołaja Kopernika w 1946 roku utworzono Katedrę Prehistorii. W artykule przedstawiono historię polsko-czeskich relacji w kilku wyróżnionych etapach, związanych z istotnymi zmianami organizacyjnymi – od Zakładu Prehistorii (lata 1946–1951), poprzez Katedrę Archeologii Polski i Powszechnej (lata 1952–1976) po Instytut Archeologii i Etnografii (lata 1976–2003).
Do radiological findings around the Fitmore stem change over time?
Authors: Fujii Hideki , Hayama Tetsuo , Abe Toshiomi , Takahashi Motoi , Amagami Ayano , Matsushita Yohei , Otani Takuya , Saito Mitsuru 
Published: January 2022

Aims Although the short stem concept in hip arthroplasty procedure shows acceptable clinical performance, we sometimes get unexplainable radiological findings. The aim of this retrospective study was to evaluate changes of radiological findings up to three years postoperatively, and to assess any potential contributing factors on such radiological change in a Japanese population. Methods This is a retrospective radiological study conducted in Japan. Radiological assessment was done in accordance with predetermined radiological review protocol. A total of 241 hips were included in the study and 118 hips (49.0%) revealed radiological change from immediately after surgery to one year postoperatively; these 118 hips were eligible for further analyses. Each investigator screened whether either radiolucent lines (RLLs), cortical hypertrophy (CH), or atrophy (AT) appeared or not on the one-year radiograph. Further, three-year radiographs of eligible cases were reviewed to determine changes such as, disappeared (D), improved (I), stable (S), and progression (P). Additionally, bone condensation (BC) was assessed on the three-year radiograph. Results CH was observed in 49 hips (21.1%), AT was observed in 63 hips (27.2%), and RLLs were observed in 34 hips (14.7%) at one year postoperatively. Among 34 hips with RLLs, 70.6% showed change of either D or I on the three-year radiograph. BC was observed in younger patients more frequently. Conclusion The Fitmore stem works well in a Japanese population with favourable radiological change on hips with RLLs. Longer-term follow-up is required to determine clinical relevance. Cite this article: Bone Jt Open 2022;3(1):20–28.
Nuevos formatos publicitarios en automoción. SEAT Mii by Cosmopolitan, branded content dirigido a mujeres.
Authors: Bonales-Daimiel Gema , Miguélez-Juan Blanca 
Published: January 2022

La adquisición de un coche implica un gran desembolso, las marcas de automóviles son conscientes de ello y por este motivo crean grandes campañas para promocionar sus modelos y dar a conocer sus valores de marca generando contenidos de interés que faciliten el proceso de compra. SEAT junto a la revista Cosmopolitan rediseñan el modelo Mii gracias a las propuestas de las lectoras y en torno al concepto #ThisIsMii creado por la agencia &Rosás lanzan una campaña de branded content dirigida a mujeres en ocho países europeos. El objetivo de la presente investigación es analizar las doce películas creadas para esta campaña y detallar el uso combinado de acciones online a partir de la metodología del estudio del caso (case study), incorporando varias técnicas como el análisis de contenido; entrevistas en profundidad y una encuesta a 300 personas de entre 18 y 65 años. Los resultados sugieren que SEAT cambia la forma de interpretar el branded content y constituye un ejemplo destacado de proyecto global entre una marca automovilística y una publicación del grupo Hearst para dar a conocer el nuevo modelo Mii y hacer que el público femenino al que se dirigen tenga una nueva mirada sobre la conducción.
Cash Benefits in Social Welfare: Transformation of Legislation and Scientific Approaches to the Definition of Employed Concepts
Authors: Mikhailenko Yulia 
Published: January 2022

The article analyzes the shortcomings of the conceptual apparatus characteristic of the right for social security in designating the types of social security provided in monetary form. In particular, there is a lack of necessary definitions (including key concepts such as "benefits" and "compensation"); lack of uniformity of terms (foregoing, the term "compensation" in some sources is used in the sense of "reimbursement of costs incurred by a person", traditional for the science of labor law, and in others a "civilized" approach to compensation as payments aimed at restoring the property sphere in case of encroachments on intangible goods is applied); "doubling" of concepts (for example, the appearance of "insurance payments" along with insurance "benefits"). Based on the analysis of the current legislation, it is concluded that there is no consistent distinction between the concepts of "benefits", "compensation", and other monetary payments. Nevertheless, a retrospective analysis of the sources of social security law, as well as ideas and approaches formed in science (not without the influence of the science of labor law), allows us to define certain types of social security payments. Unfortunately, they are not always reflected in the legislation on social security, as a result of which the scientific ideas themselves are undergoing changes, in particular, the criteria determining the essence of various social security payments are being enough. It seems that the directions for improving the system of sources of social security law should be the rejection of excessive terminological diversity in determining the types of social security, as well as the orientation to the approaches developed in science to their definition.Thus, it is proposed to use the category of benefits as a universal concept, referring to it social security payments in cash, which do not have specific features of other social security payments.
Advertising in Video Games: Legal Qualifications
Authors: Kiryshina Irina 
Published: January 2022

The article is addressed to the legal analysis of advertising placed in video games. Topical issues of the concept of advertising are touched upon from the point of view of its compliance with the legal definition enshrined in the Federal Law "On Advertising". There has been analized the distribution of advertising in video games, such as ads embedded in game content, including "product placement". In Russian legislation, there is an analogue of this
category which is defined by the legislator as “references to a product, means of its individualization, about a manufacturer or seller of a product, which are organically integrated into works of science, literature or art”. The conclusion is made about the possibility of qualifying this technique as an advertisement in the absence of a sign of "organic integration". The examples of judicial and law enforcement practice of inorganic integration are considered. In such cases, the disseminated information is recognized as advertising, in respect of which the requirements of advertising legislation regarding restrictions on advertising of tobacco and alcohol, weapons and a number of other goods must be observed. There are special requirements for video games for minors in order to protect their rights. The author presents the position regarding the qualification of targeted advertising from the point of view of its compliance with such a sign of advertising as being addressed to an indefinite group of people. The conclusion is supported by the argument that personalization of an advertising message does not exclude its qualification as an advertisement. The problem of advertising distribution in computer games, including multiplayer games, carried out via the Internet, where obtaining the preliminary consent of the online game user to receive advertising is achieved by including this condition in the user agreement, is investigated. The conclusion is made about the need to improve legal regulation in the studied field.
Olaparib-Induced Immune-Mediated Liver Injury
Authors: Alshelleh Mohammad , Park Jennifer , John Veena , Rishi Arvind , Bernstein David , Roth Nitzan 
Published: January 2022

ABSTRACT
Immune-mediated drug-induced liver injury can be triggered by multiple classes of medications including immunotherapies. Olaparib is a first-in-class oral inhibitor of poly (adenosine diphosphate-ribose) polymerase (an enzyme involved in DNA replication and repair) that is approved as maintenance treatment in platinum-sensitive, epithelial ovarian, tubal, or primary peritoneal cancers with breast cancer 1/2 mutation. We report the first case in the United States of an acute and severe liver injury with associated jaundice and liver synthetic dysfunction secondary to olaparib. The liver injury was resolved with drug cessation and treatment with prednisone taper.
Исследования надзора: основные направления и теоретические подходы
Authors: Григорьева Ксения Сергеевна 
Published: January 2022

В последние годы в российских средствах массовой информации и общественно-политическом дискурсе все чаще звучат опасения слежки со стороны государства и бизнес-корпораций. Опросы общественного мнения показывают растущую обеспокоенность населения недостаточной защитой персональных данных. Однако научная разработка этих проблем в России находится в зачаточном состоянии, а многочисленные зарубежные исследования надзора остаются малоизвестными. Данная статья призвана ознакомить русскоязычную аудиторию с иностранной научной литературой о надзоре, стимулировать развитие российских исследований в этой области. Приводится краткая история изучения слежки, прослеживается его институционализация (создание специализированных научных центров, академических сетей и журналов), дается обзор основных исследовательских направлений в указанной сфере (изучение государственного и коммерческого надзора, частно-государственного партнерства в области слежки, наблюдения работодателей за работниками, контрнаблюдения или надзора «снизу», слежки частных лиц друг за другом), рассматриваются ключевые теоретические подходы (паноптическая модель М. Фуко, концепция К.Д. Хаггерти и Р.В. Эриксона, акторно-сетевой подход, развиваемый Д.М. Вудом и К.Болл, концепция «социальной сортировки» Д. Лиона). В заключительной части делаются некоторые прогнозы относительно дальнейшего развития исследований надзора.
Únik ze spádových škol: obavy rodičů z „běžné školy“ při nástupu dítěte do 1. třídy
Authors: Smith Slámová Radka 
Published: January 2022

Na úrovni primárního vzdělávání v posledních několika letech vznikají nové typy výběrových tříd umožňující ranou selekci žáků podle kognitivních schopností či rodinného zázemí. Vzhledem k možným důsledkům těchto tříd pro spravedlivý přístup ke vzdělávání je důležité porozumět důvodům, z jakých si je rodiče vybírají. Cílem tohoto textu je objasnit, jaké obavy z „běžné školy“ přispívají k rozhodnutí rodičů zvolit výběrovou třídu při nástupu dítěte do 1. třídy. Výzkumným designem je zakotvená teorie, metodou sběru dat 21 rozhovorů se středostavovskými rodiči zvažujícími výběrové třídy ve městech. Výsledky vykreslují šest kategorií obav vztahujících se k obecné představě rodičů o „běžné české škole“ a týkajících se prostředí školy, přizpůsobování učebního tempa, naplnění rodičovy vzdělávací vize, žákovského složení, narušení harmonie rodinného života a přání rodičů docílit systémové změny. Představené obavy, založené na „horkých“ informacích spíše než na faktech o konkrétních školách, hrají důležitou roli v zamítnutí spádové školy. Diskuse v reakci na tyto obavy navrhuje školám opatření přínosná pro všechny žáky školy jako alternativu ke zřizování výběrových tříd, z nichž mají prospěch pouze někteří.
Modern understanding of pathogenesis of periodontal diseases and prospects of modulation therapy (literature review)
Authors: Zubachyk V. M. , Petryshyn O. A. , Zubachyk O. V. 
Published: January 2022

Aim. To study scientific literature which covers the onset and course of major periodontal diseases and possible methods of body modulation for such patients. To analyze the information provided by the modern scientific researches of periodontal diseases pathogenesis and treatment results to outline prospective directions of therapeutic influence on the patient’s organism.
Conclusions. The pathogenesis of gingivitis and periodontitis is determined by some factors, the main of which are local, microorganisms in particular, that are counteracted by the immune system. Periodontal tissue is in close contact with the organs and systems of the body. Their diseases significantly affect the course, treatment and prevention of periodontitis. This requires a multifaceted approach and the choice of the most effective drugs.
The primary strategy of preventing gingivitis is to eliminate the attachment of periodontal pathogens to the epithelium and surface of the teeth to prevent the penetration of microorganisms and their toxins through natural protective barriers. It is more important to resort to biological approaches using probiotics, as well as other natural media in order to prevent dysbiosis, long-term treatment, and maintenance therapy. The concept of vaccination against periodontitis is now being elaborated. Correction of the pathological process in the periodontium is considered in the context of the overall biological response of the organism. Therefore, the assessment of the role of its regulators reveals not only the features of local mechanisms, modulation pathways, but also the choice of effective drugs. Prospects of new approaches and introduction of highly effective drugs are critically analyzed.
Association of leptin receptor gene polymorphisms and meta-inflammation markers with metabolically unhealthy obesity in children
Authors: Abaturov А. Е. , Nikulina A. O. 
Published: January 2022

The aim: to study the contribution of single-nucleotide polymorphisms (SNP) of the leptin receptor (LEPR) gene and meta-inflammation markers to the formation of metabolically unhealthy obesity (MUO) in children.
Materials and methods. A total of 109 obese children aged 6–18 years were examined. Based on the recommendations of the National Heart, Lung, and Blood Institute (NHLBI), 2 observation groups were formed. The main group (n = 56) was represented by patients with MUO. The control group (n = 53) comprised children with metabolically healthy obesity (MHO). Serum levels of interleukin-1β (IL-1β) were measured using a chemiluminescent immunoassay (CLIA) method, interleukin-6, leptin, adiponectin – by enzyme-linked immunosorbent assay (ELISA) and the serum level of C-reactive protein were quantified by latex turbidimetric method (Synevo, Ukraine). The method of next-generation sequencing (NGS) (CeXGat, Germany) was used to identify LEPR SNP. Statistical methods were used: analysis of variance, Spearman’s correlation analysis and multiple discriminant analysis.
Results. In obese children aged 6 to 18 years, there was an increase in pro-inflammatory adipokines IL-6 and leptin and a decrease in anti-inflammatory adiponectin. Statistically significant changes in these indicators were more expressed in the main group: IL-6 – 7.4 ± 0.5 pg/ml (ρ = 0.65; P ≤ 0.001); adiponectin – 3.9 ± 0.8 μg/ml (ρ = -0.27; P = 0.007) among all the children examined, leptin in girls – 47.8 ± 4.4 ng/ml (ρ = -0.28; P = 0.003) compared with the results of patients in the control group: IL-6 – 4.3 ± 0.3 pg/ml, adiponectin – 7.7 ± 2.4 μg/ml, leptin in girls – 32.5 ± 4.3 ng/ml, P ≤ 0.05. The most important in the development of MUO were the following SNP of the LEPR gene: rs3790435 (CiMUO = 0.939), rs2186248 (CiMUO = 0.862), P < 0.05. A strong correlation was found between MUO and serum IL-6 level (ρ = 0.7), LEPR SNP rs3790435 (ρ = 0.7), basal hyperinsulinemia (ρ = 0.72); Р ≤ 0.001. The risk of IL-6-dependent meta-inflammation in the presence of SNP rs3790435 of the LEPR gene: OR = 17.11; 95 % CI 2.8–20.4.
Conclusions. Meta-inflammation in MUO is IL-6-dependent. Among the 10 SNPs of the LEPR gene that we identified, SNP rs3790435 of the LEPR gene has a strong association with the formation of MUO. SNP rs2186248 LEPR was described by us for the first time when it was found in 94.1 % of obese children, but it was characterized by the presence of a weak association with MUO.