bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurotrophics correlates and functional remediation in bipolar disorder. A pilot study
Authors: Accardo V. , Barlati S. , Vita A. 
Published: September 2022

IntroductionBipolar disorder (BD) is a complex mental disorder. Cognitive dysfunction represents a core feature, strongly related with patients’ functional outcome. Functional Remediation (FR), is an integrated neuropsychological and psychosocial rehabilitation treatment aimed at enhancing cognitive functions in order to achieve full functional recovery(Torrent et al., 2013). Evidence highlighted an association of neurotrophins and cognitive dysfunctions. Particularly, BDNF has been investigated a potential biomarker. Preliminary studies explored the effects induced through FR interventions on serum BDNF levels(Bonnin et al., 2019). Evidences suggest that high BDNF serum levels are related to good cognitive functioning(Mora et al., 2019). Results require further explorations. The present pilot study targets to identify the neurobiological correlates of response, investigating the potential neuroprotective role of the FR.ObjectivesAssess the effectiveness of FR in ameliorate cognitive deficits measured with BAC-A and psychosocial functioning with FAST, in modifying BDNF levels in a sample of euthymic patients with BD, compared to standard treatment.MethodsTwo arms(1:1)randomized, rater-blinded, controlled study of 30out-patients with BD-I and BD-II, according to DSM-5 criteria. Patients between 18 and 55 years in euthymic phase. Neurocognitive and clinical assessments, at the same times, serum assessment of BDNF levels will be performed.All patients will be assessed at baseline(T0), at the end of treatment(T1) and at the 3-month follow-up(T2).ResultsAfter treatment, patients receiving FR show better cognitive and psychosocial performance than those receiving TAU.ConclusionsGiven the important role of neutrophins in the pathogenesis of BD, identifying BD-specific biomarkers would contribute to understand the underlying neuro-pathophysiological processes and to personalize treatments.DisclosureNo significant relationships.
Biological determinants of functioning in euthymic patients with Bipolar Disorder: A multicentric 3-year cohort study
Authors: Cañada Y. , García-Blanco A. , Navalón P. , Sanchez Autet M. , De La Fuente Tomas L. , Garcia-Portilla M.P. , Arranz B. , Sierra San Miguel P. 
Published: September 2022

IntroductionBipolar disorder is related with functional impairment in euthymia. The contribution of biological functions such as sleep, sexual functioning; or the presence of obesity on this loss remain understudied.ObjectivesThe aim of this work was to study the influence of biological determinants in context with clinical and demographical determinants of functioning in a 3-year cohort of euthymic BD patients.MethodsIn this multicentric study 67 euthymic adult bipolar outpatients were followed during three years. Functioning was assessed with FAST, insomnia severity with Oviedo Sleep Questionnaire (OSQ) and, sexual functioning with Changes on Sexual Functioning Questionnaire (CSFQ-14) and obesity was expressed as body mass index (BMI). The basal effect of sleep, sexual functioning and obesity (Time 0) on FAST (Time 3) was analyzed with a mixed ordinal regression model including time effect, age, sex, number of manic and depressive episodes, euthymia length, and comorbidity with personality disorder. Change in functioning (Time 3 to 0) was analyzed in another mixed model also considering the difference in biological determinants (Time 3 to 0) and the presence of mood episodes during the period.ResultsA basal worse sexual functioning, a higher severity of insomnia and a higher BMI predicted a worse functioning at three years (p=0.005, p=0.043, p=0.05 respectively). Regarding FAST difference from Time0 to 3, only having a manic episode related to an impairment on functioning (p=0.027).ConclusionsSexual functioning, quality of sleep and BMI are predictors of functioning in euthymia in BD. Manic episodes in the following contribute to impairments on functioning more than depressive episodes.DisclosureNo significant relationships.
Bipolar disorders and suicide: stumbling twice with the same stone?
Authors: Sagué-Vilavella M. , Fico G. , Anmella G. , Giménez-Palomo A. , Gómez-Ramiro M. , Pons Cabrera M. , Madero S. , Vieta E. , Murru A. 
Published: September 2022

IntroductionSuicide is the most terrible outcome of bipolar disorders (BD). It impacts families and healthcare professionals deeply. Family history of suicide (FHS) is one of its main risk factors, whereas lithium treatment and absence of substance use disorders (SUD) are two of its few modifiable protective factors.ObjectivesTo explore the relationship between FHS and clinical characteristics in BD. We hypothesized that FHS would be associated with less SUD, higher rates of lithium treatment and shorter duration of untreated illness (DUI).MethodsCross-sectional analysis of subjects with BD followed-up in a specialised outpatient unit (Barcelona, October’08-March’18). We described data with measures of frequency, central tendency and dispersion, and we used χ², Fisher’s test and t-tests for comparisons.ResultsThe sample consisted of 83 subjects, 56.6% males, mean age 41.9 years (SD 12.7). 74.7% (n=62) had a diagnosis of BD-I and 25.3% (n=21) of BD-II. 11 subjects (13.3%) had FHS. Those with FHS did not show significant differences in sociodemographic data, DUI (58.5+/-60.4 vs 38.19+/-84.9 months, p=0.341), lithium use (72.7% vs 73.6%, p=0.95) or SUD (27.3% vs 23.6%, p=0.79). There were differences in terms of lifetime suicide attempts (54.5% vs 20.8%, p=0.026), family history of mental disorders (100% vs 69.4%, n=0.032).ConclusionsContrary to our hypothesis, FHS was not associated with the modifiable protective factors against suicide (namely, less SUD and more lithium prescription). Similarly, we did not find an association with earlier access to mental health services at symptom onset (DUP as proxy). Therefore, our results suggest FHS does not modify attitudes towards prevention.DisclosureNo significant relationships.
Assessment the functioning and disability in children with mental disorders
Authors: Díaz-Castro L. , Cabello-Rangel H. 
Published: September 2022

IntroductionDespite youth’s high Global Burden of Disease there is a substantial service delivery gap between this population’s urgent needs and their access to health services. Because attention has remained under-prioritized (Babatunde et al., 2019), youth typically do not receive the treatment they require, i.e., they present an unmet need (Barwick et al., 2013). This is particularly problematic given that untreated mental disorders (MD) are associated with short-term and long-term functional deterioration.ObjectivesTo determine the level of functioning of children who receive mental healthcare in the selected psychiatric hospitals of Mexico.MethodsA cross-sectional study was conducted during 2018-2020. Sample of children who received mental healthcare at the time of the study. Questionnaire for the evaluation of disability WHODAS 2.0 (World Health Organization-Disability Assessment Schedule) was applied. T test and analysis of variance were applied to know the differences of means of the variables and indicators.ResultsSample (n= 397), 63% were boys. Mean (SD) for Age: 12 (3.6) and schooling: 5.8 (3.6). 51% (n =202) of children reported having a generic diagnosis for hyperkinetic disorders and 34% depressive disorder. WHODAS scores: significant differences in the functioning domains (Do). Mean and (SD) for Do5 Life activities domestic: 45 (26.7); Do6 Social participation:37 (20.6); and Do1 cognition: 36.6 (19.3). Figure 1.ConclusionsThe children with MD are more vulnerable due to the associated disability and it requires specific heath interventions adapted to their mental health care needs. References: 1) Babatunde et al. (2021). Glob.Soc.Welfare 8, 29–46. 2) Barwick et al. (2013). J.evid.based.soc.work, 10(4), 338–352.DisclosureNo significant relationships.
Predicting involuntary admission among patients with psychotic disorder
Authors: Perfalk E. , Hansen L. , Nielbo K. , Danielsen A. , Dinesen S. 
Published: September 2022

IntroductionInvoluntary admissions are increasing in numbers across Europe.1 They can be traumatic for the patients2 and are associated with large societal costs.3 Individuals with psychotic disorder are at particularly elevated risk of involuntary admission.ObjectivesThis study aims to investigate whether machine learning methods including natural language processing can predict involuntary admission among patients with psychotic disorder.MethodsWe have obtained a dataset based on electronic health records for all patients having had at least one contact with the psychiatric services in the Central Denmark Region from 2011 to 2021. This dataset covers more than 120,000 patients, of which approximately 10,000 have been diagnosed with a psychotic disorder. The dataset contains both structured data, such as diagnoses, blood tests etc., as well as unstructured data (text). We will train machine learning models, basic logistic regression-models as well as state-of-the-art neural networks, to predict involuntary admission after contacts to the psychiatric services.ResultsAs the machine learning models are under development, no results are available at this time. Preliminary results are expected in spring 2022.ConclusionsIf involuntary admission can be predicted among patients with psychotic disorder based on data from electronic health records, it will pave the way for potentially preventive interventions. References: 1. Sheridans-Rains, L et al., 2019 2. Frueh, B.C et al., 2005 3. Smith,S., 2020DisclosureNo significant relationships.
The Effects of the COVID-19 Pandemic on Mother-Infant Mental Health Relationship
Authors: Kurimay T. 
Published: September 2022

Maternal health cannot be separated from infant, child and adolescent health, which includes mental health as well. Expecting mothers go through a number of changes during their pregnancy. Due to the specific alterations of their physique and immune system, pregnant mothers are more vulnerable to the Covid-19 infection. This highlights the importance of the vaccinations in their cases. During the pandemic, mental health problems such as anxiety, depression and stress aroused in greater numbers. This affected mothers, and younger children as well. Expecting mothers, without pre-existing mental disorder (>50%) reported a weightier level of anxiety in their first trimester. Also, infants can suffer developmental disadvantages, as their infected mothers are separated from them. Even though evidence is not yet clear in this topic, vertical transmission seems to be fairly uncommon. Treatment guidelines, that could help Covid-19 infected mothers to handle their infants, are scarce. Hence the importance of telehealth has started to be outlined. Separation from the children might be necessary, while the mental health of mother and infant is continuously screened, since the long-term consequences of the symptoms are still unknown. Hence, prevention is imperative to avoid any negative effects. Even still, WHO advises mothers to breastfeed safely, with good respiratory hygiene, emphasizing the importance of skin-to-skin contact of newborns and sharing the room with them. On policy level: investment into pre-, peri-, post-natal care, family supporting national programs, inter-sectoral collaborations, monitoring and research are important elements of prevention and treatment efforts during the Epidemic and the post-Covid-19
era.DisclosureNo significant relationships.
Clinical impact of functional CYP2C19 and CYP2D6 gene variants on treatment outcomes in patients with depression: a Danish cohort study
Authors: Thiele L. , Ishtiak-Ahmed K. , Thirstrup J. , Lunenburg C. , Müller D. , Gasse C. 
Published: September 2022

IntroductionPharmacogenetic (PGx) targets to optimize drug therapy, but its implementation is rare.ObjectivesWe evaluate the clinical utility of PGx testing in psychiatry by investigating the one-year risks of clinical outcomes in patients with depression taking sertraline, (es)citalopram or fluoxetine by their Cytochrome P450 (CYP) 2C19/2D6 phenotypes.MethodsWe investigated 17,297 individuals born between 1981-2005 with a depression diagnosis between 1996-2012 from the iPsych2012 case-cohort. Based on array-based single-nucleotide-polymorphism genotype data, individuals were phenotyped as CYP2C19/CYP2D6 normal (NM, reference group), ultra-rapid- (UM), rapid- (RM), intermediate- (IM), or poor-metabolizer (PM). Outcomes were treatment switching or discontinuation, psychiatric in-, out-, and emergency room contacts (ER), and suicide attempt/self-harm. Incidence rate ratios (IRR) by age groups were estimated using Poisson regression analysis with 95% confidence intervals, adjusted for potential confounders.ResultsRisks of switching (IRR=1.89[1.22-2.93]), ERs (1.69 [1.01-2.81]) and suicide attempt/self-harm (2.73 [1.49-5.01]) were higher in CYP2C19 PMs <19 years taking (es)citalopram. Fluoxetine users <19 years had a decreased risk of discontinuation in CYP2D6 PMs (0.5 [0.27-0.95]) and decreased risk of out-patient contacts in CYP2D6 PMs and IMs (IRRIM=0.83 [0.68-1.00] and IRRPM=0.59 [ 0.37-0.96]). We observed an increased risk for ERs in CYP2D6 PMs aged 19-25 years taking fluoxetine (4.53 [1.54-13.35]). In CYP2C19 UMs >25 years taking (es)citalopram the risk of suicide attempt/self-harm was more than three-fold increased (3.64 [ 1.01-13.19]). We found no significant results in users of sertraline.ConclusionsPGx variability was associated with treatment outcomes in depression in patients with CYP2C19 PM or UM status taking (es)citalopram, or CYP2D6 PM or IM status taking fluoxetine.DisclosureNo significant relationships.
Body mass index and depressive rumination are positively associated with each other only in case of GG genotype of catenin alpha 2 gene rs13412541 variant
Authors: Eszlari N. , Bagyura Z. , Millinghoffer A. , Nagy T. , Juhasz G. , Antal P. , Merkely B. , Bagdy G. 
Published: September 2022

IntroductionCatenin alpha 2 gene (CTNNA2) is important in the stability of hippocampal synapses and also in brain development. Our recent paper (Eszlari et al, Pharmaceuticals 2021, 14, 850) has demonstrated that rumination on sad mood mediates the association of CTNNA2 only towards psychiatric symptoms, but not towards cardiovascular risk phenotypes.ObjectivesOur present aim was to test the moderating role of rumination and its two subtypes, brooding and reflection, in genetic associations between CTNNA2 and the same cardiovascular risk phenotypes.Methods633 unrelated subjects from the Budakalasz Health Examination Survey with non-missing phenotypic data, and 160 single-nucleotide CTNNA2 variants remaining after quality control, were included. Linear regression models were run in Plink 1.9 for separate outcomes of body mass index (BMI), and Framingham risk scores for cardiovascular disease, coronary heart disease, myocardial infarction, and stroke. With each variant, predictors were the variant, rumination or its subtype, the variant x rumination interaction, sex, age, and the top ten principal components of the genome. 100,000 label-swapping max(T) permutation was applied for the interaction term within each analysis.ResultsWhile no significant interaction term survived the familywise permutation, two trends emerged. Namely, BMI seems to have positive association with rumination and its maladaptive brooding subtype only in case of GG genotype of rs13412541, otherwise no association can be detected.ConclusionsAlthough replication is needed in larger samples, the relationship between rumination and BMI, conditional on CTNNA2 genotype, can be important in atypical depression, thus may contribute to stratification of depressed patients.DisclosureThe study was supported by the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (ÚNKP-21-4-II-SE-1); and by 2019-2.1.7-ERA-NET-2020-00005.
Psychofarmacological approach for Binge- eating disorders
Authors: Muñoz Martinez V. , Beato-Fernández L. , Segura-Escobar E. 
Published: September 2022

IntroductionBinge-eating disorder (BED), is one of the most common eating disorder. Treatment aims to reduce binge-eating frequency and disordered eating–related cognitions, improve metabolic health and weight, and regulate mood (in patients with coexisting depression or anxiety)ObjectivesThe aim of this study was to examine the efficacy of lisdexamfetamine dimesylate in a simple of 50 women with a binge eating disorder diagnosis compare with selective serotonin reuptake inhibitorMethodsTwo groups were made, one with lisdexamfetamine and the other with selective serotonin reuptake inhibitor (fluoxetine). 20 women were in each group (total n=40). The doses depend of the binge symptoms and rates were from 30 to 70md/day for lisdexamfetamine and for fluoxetine the doses were from 20 to 60mg/day.ResultsBinge behaviors decreased with a 50mg/day dose of lisdexamfetamine. The 70mg/day doses present also less binge behaviors but also more adverse events. The 30mg/day doses did not decrease binge-eating behaviors.ConclusionsLisdexamfetamine is the first pharmacological agent to receive FDA approval for use in adults with moderate to severe binge eating disorder. This study supports further assessment of lisdexamfetamine as a treatment option for decreasing binge eating behavior and also symptoms associated such as anxiety and obsessive and compulsive features in adults.Increased efficacy with increasing dosages of lisdexamfetamine suggests a dose-response relationship until 50mg/day. Women with a dose of 50mg/day of lisdexamfetamine report less adverse event, more adherence to treatment and improve their eating behaviors.DisclosureNo significant relationships.
Clinical phenotypes of autism spectrum disorders and epilepsy comorbidity
Authors: Skrypnyk T. 
Published: September 2022

IntroductionASD with epileptic seizures (ES) and/or specific epileptic activity on EEG (EEG SEA) and repetitive movements and vocalizations (RMV) can be determined by different variants of genetic polymorphism or by different variants of gene expression, determined by different influences.ObjectivesTo study the features of the clinical phenotype of ASD in preschool and school-age children with ES, EEG SEA and RMV.Methods: The study group was divided 116 children aged 2-10 years with ASD into three subgroups: subgroup A - 23 children with a history of ES, subgroup B - 35 children with EEG SEA without ES, subgroup C - 19 children with ASD having EEG SEA, RMV (motor stereotypes, motor tics and/or vocal tics). The control group consisted of 39 children with ASD non a history of ES and EEG SEA.Results: Children with ASD, complicated by severe and frequent ES are charactered by impaired social reciprocity and communication against the background of regression / stagnation of speech and motor skills development (aOR: 2,7 [1,7-4,8]). Disoders of communication and repetitive behavior in ASD in children of different ages are represented by different monoqualitative syndrome (phenotypes). Movement stereotypes predominated in children with ASD without ES and without EEG SEA (aOR: [1,8-7,9]). In children with ASD and EEG SEA, motor stereotypes and repetitive behavior were equally common ([SD] 2.1 -1, P =0.81).Conclusions: Disorders of social reciprocity, communication, repetitive behavior are diagnostically significant for ASD complicated by ES, ASD with EEG SEA.DisclosureNo significant relationships.
Psychological well-being in Hungarian students with specific learning disorders (SpLD)
Authors: Dudok R. , Pikó B. 
Published: September 2022

IntroductionThe specific learning disorders (SpLD) are neurology based development disorders which are characterized by significant difficulties in acquiring learning skills. SpLD are often accompanied by mental health problems because of emotional and behavioral consequences of the diagnosis. While the presence of SpLD can worsen psychological well-being among school aged children, resilience factors can neutralize these harmful effects.ObjectivesThe aim of this research is to identify protective factors promoting development of psychologial well-being and mental health in adolescents with SpLD compared to a control group of peers without this diagnosis.MethodsHungarian primary school students (N = 174; M = 13.34 years, SD = 1.14) participated in the study aged between 11 to 15 years. Of these, 23.6% students had a SpLD diagnosis. Participants completed a paper pencil-based questionnaire that included: EPOCH Psychological Well-being Questionnaires of Adolescent, WHO Well-being Index, Satisfaction With Life Scale, Multidimensional Perceived Social Support Scale, The Connor-Davidson Resilience Scale, and Self-regulation Scale.ResultsPsychological well-being in both groups shows positive correlation (p<0.01) with general well-being, satisfaction with life, social support, self-esteem and self-control. In the SpLD group, the engagement and connectedness subscales do not relate to the general well-being and life satisfaction, in contrast with the control group in which these are associated with both. Self-control shows stronger correlation with general well-being and with engagement and connectedness subscales as compared to the control group (p<0.01).ConclusionsThere are differences in contributing factors of general psychological well-being in adolescents with SpLD and those without this diagnosis.DisclosureNo significant relationships.
Results of Maladaptive Behavior Gender Characteristics Diagnostics in Primary School Children with Disabilities (Pilot Study)
Authors: Fadeeva E. , Shakun E. 
Published: September 2022

IntroductionThe maladaptive children behavior analysis is important for determining effective methods of prevention and care.ObjectivesThe aim of the study was to identify general and gender-specific features of maladaptive behavior in children of primary school age with disabilities.MethodsThe sample included 77 children 8.6±1.03 years of age, among them 57 boys and 20 girls. Maladaptive children behavior was assessed using VABS. The statistical significance of the differences between variables was determined by Pearson`s Chi-squared test. Indicators of maladaptive behavior were assessed by calculation of frequency distribution and contingency tables.ResultsMaladaptive behavior features common for both genders included impulsivity, physical aggression, taunting, teasing and bullying, insensitivity to others, having poor eye contact. Having a hard time paying attention was statistically significantly more common among boys (p≤0.05). Boys were more likely to disobey and defy those in authority, to lie, cheat or steal. A specific feature of maladaptive behavior for girls was having eating difficulties and overly dependent behavior on caregivers or siblings. Comparative analysis of the additional VABS section results showed that obsession with thoughts or activities predominated among boys, as well as expression of thoughts that do not make sense. The following indicators were found only in boys: strange habits or ways (makes repetitive noises, odd hand movements, etc.) (14%), bizarre speech (conversations with self in public, repeating the same word or phrase, etc.) (7%).ConclusionsDescribed signs of children’s maladjustment can be used for the purposes of diagnostics, prevention and care.DisclosureNo significant relationships.