bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transfusion of non‐prophylactically RH‐KEL1 antigen‐matched red blood cells is feasible in selected myelodysplastic syndrome and acute myeloid leukaemia patients
Authors: Xhaard Aliénor , Miekoutima Elsa , Pirenne France , François Anne , Tiberghien Pierre , Sebert Marie , Adès Lionel , Fenaux Pierre , Leprêtre Anne‐Claire 
Published: January 2022

AbstractBackground and ObjectivesMost myelodysplastic syndromes (MDS) patients become red blood cell (RBC) transfusion‐dependent. Transfusing MDS patients with prophylactically RH‐KEL1 antigen‐matched (PAM) RBC units is recommended to avoid RBC allo‐immunization. D+C−E−c+e+, D+C−E+c+e− and D+C+E−c−e+ phenotypes are infrequent among French blood donors. To preserve infrequent phenotype RBC units for patients other than MDS, and to manage frequent phenotype RBC unit stocks, we let, for 1 year, higher‐risk non‐immunized chronically transfused MDS and acute myeloid leukaemia (AML) patients receive RBC transfusions matched only for D. Our objectives were to evaluate the impact of non‐PAM transfusions on the transfusion policy (which would be modified in case of RBC allo‐immunization) for frequent and infrequent phenotypes patients and to estimate the number of infrequent phenotypes RBC units that could be redistributed to other patients.ResultsNinety patients were enrolled. Thirty‐five patients had infrequent phenotypes, nine received only PAM RBC (143 units) and 26 PAM and non‐PAM RBC (415 and 532, respectively): none developed allo‐immunization. Fifty‐five patients had frequent RBC phenotypes, 34 received only PAM RBC (561 units) and three developed antibodies (2 non‐RH‐KEL1 and one anti‐E); 21 received PAM and non‐PAM RBC (436 and 109, respectively) and one developed allo‐immunization (unknown specificity). Our strategy enabled us to preserve 532 infrequent phenotypes RBC units: 216 D+C−E−c+e+, 33 D+C−E+c+e− and 283 D+C+E−c−e+ units, representing 48.8% of the total number of RBC units received by infrequent phenotypes patients during the study period.ConclusionAllowing the transfusion of non‐PAM RBC in selected chronically transfused MDS and AML patients was feasible and enabled to redistribute infrequent phenotypes RBC units to other patients in need.
Tectonic controls on Quaternary landscape evolution in the Ventura basin, southern California, USA, quantified using cosmogenic isotopes and topographic analyses
Authors: Hughes A. , Rood D.H. , DeVecchio D.E. , Whittaker A.C. , Bell R.E. , Wilcken K.M. , Corbett L.B. , Bierman P.R. , Swanson B.J. , Rockwell T.K. 
Published: January 2022

AbstractThe quantification of rates for the competing forces of tectonic uplift and erosion has important implications for understanding topographic evolution. Here, we quantify the complex interplay between tectonic uplift, topographic development, and erosion recorded in the hanging walls of several active reverse faults in the Ventura basin, southern California, USA. We use cosmogenic 26Al/10Be isochron burial dating and 10Be surface exposure dating to construct a basin-wide geochronology, which includes burial dating of the Saugus Formation: an important, but poorly dated, regional Quaternary strain marker. Our ages for the top of the exposed Saugus Formation range from 0.36 +0.18/-0.22 Ma to 1.06 +0.23/-0.26 Ma, and our burial ages near the base of shallow marine deposits, which underlie the Saugus Formation, increase eastward from 0.60 +0.05/-0.06 Ma to 3.30 +0.30/-0.41 Ma. Our geochronology is used to calculate rapid long-term reverse fault slip rates of 8.6–12.6 mm yr–1 since ca. 1.0 Ma for the San Cayetano fault and 1.3–3.0 mm yr–1 since ca. 1.0 Ma for the Oak Ridge fault, which are both broadly consistent with contemporary reverse slip rates derived from mechanical models driven by global positioning system (GPS) data. We also calculate terrestrial cosmogenic nuclide (TCN)-derived, catchment-averaged erosion rates that range from 0.05–1.14 mm yr–1 and discuss the applicability of TCN-derived, catchment-averaged erosion rates in rapidly uplifting, landslide-prone landscapes. We compare patterns in erosion rates and tectonic rates to fluvial response times and geomorphic landscape parameters to show that in young, rapidly uplifting mountain belts, catchments may attain a quasi-steady-state on timescales of &lt;105 years even if catchment-averaged erosion rates are still adjusting to tectonic forcing.
Middle–Late Triassic southward-younging granitoids: Tectonic transition from subduction to collision in the Eastern Tianshan–Beishan Orogen, NW China
Authors: Mao Qigui , Ao Songjian , Windley Brian F. , Zhang Zhiyong , Sang Miao , Tan Zhou , Wang Hao , Li Rui , Xiao Wenjiao , Pan Zhuo 
Published: January 2022

Abstract
To constrain the closure mechanism and time of the Paleo-Asian Ocean, we report new geochronological and geochemical data for Triassic granites along a NW–SE corridor from Eastern Tianshan to Beishan, NW China. Seven granites have U-Pb ages that young southwards from 245 Ma to 234 Ma in the Kanguer accretionary complex, to 237 Ma to 234 Ma in the eastern Central Tianshan block, to 229 Ma to 223 Ma in the Liuyuan accretionary complex. Granites in the Kanguer accretionary complex formed by fractional crystallization and are peraluminous, high-K, calc-alkaline, and crust-derived. They have very low MgO (Mg# = 6–9), Cr, and Ni contents, and their high εNd(t) (+3.40) and εHf(t) (+4.49 to +11.91) isotopes indicate that the Dananhu arc crust was juvenile. The Huaniushan pluton in the Liuyuan accretionary complex displays the geochemical signatures of both A1- and A2-type granites (Y/Nb = 0.32–3.39). All other granites in the Central Tianshan block and Liuyuan accretionary complex are aluminous A2-types with high K2O + Na2O, Al, rare earth elements (REE), Zr + Nb + Y, Ga, Fe/Mg, and Y/Nb and remarkable depletions of Eu, Ba, Nb, Ta, Sr, P, and Ti. They have a broad range of MgO (Mg# = 9–59), Cr, and Ni contents, Isr (0.70741–0.70945) values, negative εNd (t) (−2.98 to −1.14), and low to moderate εHf(t) (−1.22 to +7.78), which suggests a mixture of mantle and crustal components. These 245–223 Ma granitoids show marked Nb-Ta depletions that point to a subduction origin. Notable enrichments in Nd-Hf isotopes of Late Triassic granites are likely an indication of collision. Integration with previous data enables us to conclude that the delamination of an oceanic slab and mantle upwelling induced partial melting of thickened arc crust during a tectonic transition from a multiple supra-subduction margin to a collisional setting in the Late Triassic.
A red bole zircon record of cryptic silicic volcanism in the Deccan Traps, India
Authors: O’Connor Liam , Szymanowski Dawid , Eddy Michael P. , Samperton Kyle M. , Schoene Blair 
Published: January 2022

Abstract
Silicic magmas within large igneous provinces (LIPs) are understudied relative to volumetrically dominant mafic magmas despite their prevalence and possible contribution to LIP-induced environmental degradation. In the 66 Ma Deccan LIP (India), evolved magmatism is documented, but its geographic distribution, duration, and significance remain poorly understood. Zircons deposited in weathered Deccan lava flow tops (“red boles”) offer a means of indirectly studying potentially widespread, silicic, explosive volcanism spanning the entire period of flood basalt eruptions. We explored this record through analysis of trace elements and Hf isotopes in zircon crystals previously dated by U–Pb geochronology. Our results show that zircon populations within individual red boles fingerprint distinct volcanic sources that likely developed in an intraplate setting on cratonic Indian lithosphere. However, our red bole zircon geochemical and isotopic characteristics do not match those from previously studied silicic magmatic centers, indicating that they must derive from yet undiscovered or understudied volcanic centers associated with the Deccan LIP.
Diagnostic reasoning in cardiovascular medicine
Authors: Brush John E , Sherbino Jonathan , Norman Geoffrey R 
Published: January 2022

ABSTRACTResearch in cognitive psychology shows that expert clinicians make a medical diagnosis through a two step process of hypothesis generation and hypothesis testing. Experts generate a list of possible diagnoses quickly and intuitively, drawing on previous experience. Experts remember specific examples of various disease categories as exemplars, which enables rapid access to diagnostic possibilities and gives them an intuitive sense of the base rates of various diagnoses. After generating diagnostic hypotheses, clinicians then test the hypotheses and subjectively estimate the probability of each diagnostic possibility by using a heuristic called anchoring and adjusting. Although both novices and experts use this two step diagnostic process, experts distinguish themselves as better diagnosticians through their ability to mobilize experiential knowledge in a manner that is content specific. Experience is clearly the best teacher, but some educational strategies have been shown to modestly improve diagnostic accuracy. Increased knowledge about the cognitive psychology of the diagnostic process and the pitfalls inherent in the process may inform clinical teachers and help learners and clinicians to improve the accuracy of diagnostic reasoning. This article reviews the literature on the cognitive psychology of diagnostic reasoning in the context of cardiovascular disease.
Humoral response to SARS-CoV-2 infection among liver transplant recipients
Authors: Becchetti Chiara , Broekhoven Annelotte G C , Dahlqvist Géraldine , Fraga Montserrat , Zambelli Marco Fabrizio , Ciccarelli Olga , Saouli Anne-Catherine , Trizzino Arianna , Banz Vanessa , Dufour Jean-François , Roukens Anna H E , Torres Morales Shessy P , Myeni Sebenzile K , Kikkert Marjolein , Feltkamp Mariet C W , Coenraad Minneke J 
Published: January 2022

ObjectiveImmunosuppressive agents are known to interfere with T and/or B lymphocytes, which are required to mount an adequate serologic response. Therefore, we aim to investigate the antibody response to SARS-CoV-2 in liver transplant (LT) recipients after COVID-19.DesignProspective multicentre case–control study, analysing antibodies against the nucleocapsid protein, spike (S) protein of SARS-CoV-2 and their neutralising activity in LT recipients with confirmed SARS-CoV-2 infection (COVID-19-LT) compared with immunocompetent patients (COVID-19-immunocompetent) and LT recipients without COVID-19 symptoms (non-COVID-19-LT).ResultsOverall, 35 LT recipients were included in the COVID-19-LT cohort. 35 and 70 subjects fulfilling the matching criteria were assigned to the COVID-19-immunocompetent and non-COVID-19-LT cohorts, respectively. We showed that LT recipients, despite immunosuppression and less symptoms, mounted a detectable antinucleocapsid antibody titre in 80% of the cases, although significantly lower compared with the COVID-19-immunocompetent cohort (3.73 vs 7.36 index level, p<0.001). When analysing anti-S antibody response, no difference in positivity rate was found between the COVID-19-LT and COVID-19-immunocompetent cohorts (97.1% vs 100%, p=0.314). Functional antibody testing showed neutralising activity in 82.9% of LT recipients (vs 100% in COVID-19-immunocompetent cohort, p=0.024).ConclusionsOur findings suggest that the humoral response of LT recipients is only slightly lower than expected, compared with COVID-19 immunocompetent controls. Testing for anti-S antibodies alone can lead to an overestimation of the neutralising ability in LT recipients. Altogether, routine antibody testing against separate SARS-CoV-2 antigens and functional testing show that the far majority of LT patients are capable of mounting an adequate antibody response with neutralising ability.
Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability
Authors: Liu Xiaoyu , Li Zhi , Wang Zhongmin , Liu Fei , Zhang Linling , Ke Jingjing , Xu Xu , Zhang Yuefang , Yuan Yiting , Wei Tao , Shan Qungang , Chen Yingjie , Huang Wei , Gao Jie , Wu Nan , Chen Fuliang , Sun Lunquan , Qiu Zilong , Deng Yuezhen , Wang Xiaojing 
Published: January 2022

Abstract

ARID1A is a key mammalian SWI/SNF complex subunit that is mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation of the switch/sucrose non-fermentable (SWI/SNF) complexes in cancers, the significance of ARID1A loss and its implications in lung cancers remain poorly defined. This study investigates how ARID1A loss affects initiation and progression of lung cancer. In genetically engineered mouse models bearing mutant Kras and a deficient Trp53 allele (KP), ARID1A loss (KPA) promoted lung tumorigenesis. Analysis of the transcriptome profiles of KP and KPA tumors suggested enhanced glycolysis following ARID1A loss, and expression of the glycolytic regulators Pgam1, pyruvate kinase M (Pkm), and Pgk1 was significantly increased in ARID1A-deficient lung tumors. Furthermore, ARID1A loss increased chromatin accessibility and enhanced hypoxia-inducible factor-1α (HIF1α) binding to the promoter regions of Pgam1, Pkm, and Pgk1. Loss of ARID1A in lung adenocarcinoma also resulted in loss of histone deacetylase 1 (HDAC1) recruitment, increasing acetylation of histone-4 lysine at the promoters of Pgam1, Pkm, and Pgk1, and subsequently enhancing BRD4-driven transcription of these genes. Metabolic analyses confirmed that glycolysis is enhanced in ARID1A-deficient tumors, and genetic or pharmacologic inhibition of glycolysis inhibited lung tumorigenesis in KPA mice. Treatment with the small molecule bromodomain and extraterminal protein (BET) inhibitor JQ1 compromised both initiation and progression of ARID1A-deficient lung adenocarcinoma. ARID1A negatively correlated with glycolysis-related genes in human lung adenocarcinoma. Overall, ARID1A loss leads to metabolic reprogramming that supports tumorigenesis but also confers a therapeutic vulnerability that could be harnessed to improve the treatment of ARID1A-deficient lung cancer.

Significance:
This study links ARID1A loss with enhanced glycolysis in lung cancer and demonstrates the preclinical efficacy of BET inhibitor therapy as a strategy to combat tumor growth.
Educational Attainment, Race, and Ethnicity as Predictors for Ideal Cardiovascular Health: From the National Health and Nutrition Examination Survey
Authors: Johnson Amber E. , Herbert Brandon M. , Stokes Natalie , Brooks Maria M. , Needham Belinda L. , Magnani Jared W. 
Published: January 2022

Background
Educational attainment is protective for cardiovascular health (CVH), but the benefits of education may not persist across racial and ethnic groups. Our objective was to determine whether the association between educational attainment and ideal CVH differs by race and ethnicity in a nationally representative sample.

Methods and Results

Using the National Health and Nutrition Examination Survey, we determined the distribution of ideal CVH, measured by Life’s Simple 7, across levels of educational attainment. We used multivariable ordinal logistic regression to assess the association between educational attainment (less than high school, high school graduate, some college, college graduate) and Life’s Simple 7 category (ideal, intermediate, poor), by race and ethnicity (Asian, Black, Hispanic, White). Covariates were age, sex, history of cardiovascular disease, health insurance, access to health care, and income–poverty ratio. Of 7771 National Health and Nutrition Examination Survey participants with complete data, as level of educational attainment increased, the criteria for ideal health were more often met for most metrics. After adjustment for covariates, effect of education was attenuated but remained significant (
P
<0.01). Those with at least a college degree had 4.12 times the odds of having an ideal Life’s Simple 7 compared with less than high school (95% CI, 2.70–5.08). Among all racial and ethnic groups, as level of educational attainment increased, so did Life’s Simple 7. The magnitude of the association between education and CVH varied by race and ethnicity (interaction
P
<0.01).

Conclusions
Our findings demonstrate that educational attainment has distinct associations with ideal CVH that differs by race and ethnicity. This work demonstrates the need to elucidate barriers preventing individuals from racial and ethnic minority groups from achieving equitable CVH.
Seasonal Variability in the Mechanisms behind the 2020 Siberian Heatwaves
Authors: Collow Allison B. Marquardt , Thomas Natalie P. , Bosilovich Michael G. , Lim Young-Kwon , Schubert Siegfried D. , Koster Randal D. 
Published: January 2022

Abstract
Record-breaking heatwaves and wildfires immersed Siberia during the boreal spring of 2020 following an anomalously warm winter. Springtime heatwaves are becoming more common in the region, with statistically significant trends in the frequency, magnitude, and duration of heatwave events over the past four decades. Mechanisms by which the heatwaves occur and contributing factors differ by season. Winter heatwave frequency is correlated with the atmospheric circulation, particularly the Arctic Oscillation, while the frequency of heatwaves during the spring months is highly correlated with aspects of the land surface including snow cover, albedo, and latent heat flux. Idealized AMIP-style experiments are used to quantify the contribution of suppressed Arctic sea ice and snow cover over Siberia on the atmospheric circulation, surface energy budget, and surface air temperature in Siberia during the winter and spring of 2020. Sea ice concentration contributed to the strength of the stratospheric polar vortex and Arctic Oscillation during the winter months, thereby influencing the tropospheric circulation and surface air temperature over Siberia. Warm temperatures across the region resulted in an earlier-than-usual recession of the winter snowpack. The exposed land surface contributed to up to 20% of the temperature anomaly during the spring through the albedo feedback and changes in the ratio of the latent and sensible heat fluxes. This, in combination with favorable atmospheric circulation patterns, resulted in record-breaking heatwaves in Siberia in the spring of 2020.
Spontaneous Breathing for Panendoscopy? Retrospective Cohort and Results of a French Practice Survey
Authors: Habrial Pierre , Léger Maxime , Costerousse Fabienne , Debiasi Julie , Breheret Renaud , Vacheron Charles‐Hervé , Rineau Emmanuel , Lasocki Sigismond 
Published: January 2022

ObjectiveAvoiding tracheal intubation by using general anesthesia with spontaneous breathing (GASB) is attractive for upper airway panendoscopy. The aim of this study was to estimate the incidence of adverse events during panendoscopy under GASB and to assess the practices of French anesthesiologists.Study DesignTwo‐phase study: monocentric retrospective study and national survey.SettingUniversity hospital center.MethodsPatients who underwent a panendoscopy under GASB at the University Hospital of Angers between January 1 and December 31, 2014, were reviewed. Failure of GASB was defined as an episode of hypoxemia (SpO2 ≤88%) or the need for face mask ventilation with or without tracheal intubation. Then, we sent an electronic survey to all members of the French Society of Anaesthesia and Intensive Care.ResultsAmong the 95 included patients, 22 (23%) experienced a failure of GASB: 3 tolerated hypoxemia, 15 had face mask ventilation episodes, and 4 were intubated. Three factors were associated with failure: obesity (odds ratio, 11.94; 95% CI, 3.20‐44.64), history of difficult intubation defined as a Cormack score ≥3 (odds ratio, 6.20; 95% CI, 1.51‐25.41), and laryngeal tumor (odds ratio, 2.81; 95% CI, 1.04‐7.56). Among the 3930 members of the French Society of Anaesthesia and Intensive Care in 2018, 662 (16.8%) responded to the survey. The 2 preferred techniques to perform panendoscopy were intubation (62%) and intravenous sedation with spontaneous breathing (37%).ConclusionAlthough general anesthesia with orotracheal intubation remains the preferred technique for panendoscopy in France, GASB is an attractive alternative with a low failure rate. Risk factors for failure are obesity, history of difficult intubation, and laryngeal tumor.
Transcriptional analysis of Bemisia tabaci MEAM1 cryptic species under the selection pressure of neonicotinoids imidacloprid, acetamiprid and thiamethoxam
Authors: Zhou Cheng Song , Lv Huan Huan , Guo Xiao Hu , Cao Qian , Zhang Rui Xingyue , Ma De Ying 
Published: January 2022

Abstract
Background
Neonicotinoids are widely applied in the control of the destructive agricultural pest Bemisia tabaci, and resistance against these chemicals has become a common, severe problem in the control of whiteflies. To investigate the molecular mechanism underlying resistance against nenonicotinoids in whiteflies, RNA-seq technology was applied, and the variation in the transcriptomic profiles of susceptible whiteflies and whiteflies selected by imidacloprid, acetamiprid and thiamethoxam treatment was characterized.

Results
A total of 90.86 GB of clean sequence data were obtained from the 4 transcriptomes. Among the 16,069 assembled genes, 584, 110 and 147 genes were upregulated in the imidacloprid-selected strain (IMI), acetamiprid-selected strain (ACE), and thiamethoxam (THI)-selected strain, respectively, relative to the susceptible strain. Detoxification-related genes including P450s, cuticle protein genes, GSTs, UGTs and molecular chaperone HSP70s were overexpressed in the selected resistant strains, especially in the IMI strain. Five genes were downregulated in all three selected resistant strains, including 2 UDP-glucuronosyltransferase 2B18-like genes (LOC 109030370 and LOC 109032577).

Conclusions
Ten generations of selection with the three neonicotinoids induced different resistance levels and gene expression profiles, mainly involving cuticle protein and P450 genes, in the three selected resistant whitefly strains. The results provide a reference for research on resistance and cross-resistance against neonicotinoids in B. tabaci.