bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended Kalman filter algorithm for non-roughness and moving damage identification
Authors: Ding Hong-li , Zhang Chun , Gao Yu-wei , Huang Jin-peng 
Published: December 2022

AbstractIt is a promising method to identify structural damage using bridge dynamic response under moving vehicle excitation, but the lack of accurate information about road roughness and vehicle parameters will lead to the failure of this method. The paper proposed a step-by-step EKF damage identification method, which transforms the inversion problem of unknown structural parameters under unknown loads (vehicle and road roughness) into two separate inversion problems: moving contact force identification and damage parameters identification. Firstly, the VBI model is converted into bridge vibration model under a moving contact force, and the moving contact force covering the information of road roughness and vehicle parameters can be calculated by EKF iteration. Secondly, the moving contact force identified in the first step is loaded on the bridge as a known condition, and the bridge damage problem is also solved by the EKF method. Numerical analyses of a simply-supported bridge under the moving vehicle are conducted to investigate the accuracy and efficiency of the proposed method. Effects of the vehicle speed, the damage cases, the measurement noise, and the roughness levels on the accuracy of the identification results are investigated. The results demonstrate the proposed algorithm is efficient and robust, and the algorithm can be developed into an effective tool for structural health monitoring of bridges.
An interpretable artificial intelligence system for detecting risk factors of gastroesophageal variceal bleeding
Authors: Wang Jing , Wang Zhengqiang , Chen Mingkai , Xiao Yong , Chen Shi , Wu Lianlian , Yao Liwen , Jiang Xiaoda , Li Jiao , Xu Ming , Lin Mengjuan , Zhu Yijie , Luo Renquan , Zhang Chenxia , Li Xun , Yu Honggang 
Published: December 2022

AbstractBleeding risk factors for gastroesophageal varices (GEV) detected by endoscopy in cirrhotic patients determine the prophylactical treatment patients will undergo in the following 2 years. We propose a methodology for measuring the risk factors. We create an artificial intelligence system (ENDOANGEL-GEV) containing six models to segment GEV and to classify the grades (grades 1–3) and red color signs (RC, RC0-RC3) of varices. It also summarizes changes in the above results with region in real time. ENDOANGEL-GEV is trained using 6034 images from 1156 cirrhotic patients across three hospitals (dataset 1) and validated on multicenter datasets with 11009 images from 141 videos (dataset 2) and in a prospective study recruiting 161 cirrhotic patients from Renmin Hospital of Wuhan University (dataset 3). In dataset 1, ENDOANGEL-GEV achieves intersection over union values of 0.8087 for segmenting esophageal varices and 0.8141 for gastric varices. In dataset 2, the system maintains fairly accuracy across images from three hospitals. In dataset 3, ENDOANGEL-GEV surpasses attended endoscopists in detecting RC of GEV and classifying grades (p < 0.001). When ranking the risk of patients combined with the Child‒Pugh score, ENDOANGEL-GEV outperforms endoscopists for esophageal varices (p < 0.001) and shows comparable performance for gastric varices (p = 0.152). Compared with endoscopists, ENDOANGEL-GEV may help 12.31% (16/130) more patients receive the right intervention. We establish an interpretable system for the endoscopic diagnosis and risk stratification of GEV. It will assist in detecting the first bleeding risk factors accurately and expanding the scope of quantitative measurement of diseases.
Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines
Authors: Brochu Hayden , Wang Ruihan , Tollison Tammy , Pyo Chul-Woo , Thomas Alexander , Tseng Elizabeth , Law Lynn , Picker Louis J. , Gale Michael , Geraghty Daniel E. , Peng Xinxia 
Published: December 2022

AbstractRhesus cytomegalovirus (RhCMV)-based vaccination against Simian Immunodeficiency virus (SIV) elicits MHC-E-restricted CD8+ T cells that stringently control SIV infection in ~55% of vaccinated rhesus macaques (RM). However, it is unclear how accurately the RM model reflectsHLA-Eimmunobiology in humans. Using long-read sequencing, we identified 16Mamu-Eisoforms and allMamu-Esplicing junctions were detected amongHLA-Eisoforms in humans. We also obtained the completeMamu-Egenomic sequences covering the full coding regions of 59 RM from a RhCMV/SIV vaccine study. TheMamu-Egene was duplicated in 32 (54%) of 59 RM. Among four groups ofMamu-Ealleles: three ~5% divergent full-length allele groups (G1, G2, G2_LTR) and a fourth monomorphic group (G3) with a deletion encompassing the canonicalMamu-Eexon 6, the presence of G2_LTR alleles was significantly (p = 0.02) associated with the lack of RhCMV/SIV vaccine protection. These genomic resources will facilitate additionalMHC-Etargeted translational research.
TIPARP is involved in the regulation of intraocular pressure
Authors: Zhang Youjia , Song Maomao , Bi Yingwen , Lei Yuan , Sun Xinghuai , Chen Yuhong 
Published: December 2022

AbstractElevated intraocular pressure (IOP) is the major risk factor for glaucoma. The molecular mechanism of elevated IOP is unclear, which impedes glaucoma therapy. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible Poly-ADP-ribose Polymerase (TIPARP), a member of the PARP family, catalyses mono-ADP-ribosylation. Here we showed that TIPARP was widely expressed in the cornea, trabecular meshwork, iris, retina, optic nerve, sclera, and choroid of human eyes. The expression of TIPARP was significantly upregulated in the blood and trabecular meshwork of patients with primary open angle glaucoma compared with that of healthy controls. Transcriptome analysis revealed that the expression of genes related to extracellular matrix deposition and cell adhesion was decreased in TIPARP-upregulated human trabecular meshwork (HTM) cells. Moreover, western blot analysis showed that collagen types I and IV, fibronectin, and α-SMA were increased in TIPARP-downregulated or TIPARP-inhibited HTM cells. In addition, cross-linked actin networks were produced, and vinculin was upregulated in these cells. Subconjunctival injection of the TIPARP inhibitor RBN-2397 increased the IOP in Sprague–Dawley rats. Therefore, we identified TIPARP as a regulator of IOP through modulation of extracellular matrix and cell cytoskeleton proteins in HTM cells. These results indicate that TIPARP is a potential therapeutic target for ocular hypertension and glaucoma.
Neolithic dental calculi provide evidence for environmental proxies and consumption of wild edible fruits and herbs in central Apennines
Authors: D’Agostino Alessia , Di Marco Gabriele , Marvelli Silvia , Marchesini Marco , Rizzoli Elisabetta , Rolfo Mario Federico , Canini Antonella , Gismondi Angelo 
Published: December 2022

AbstractLooking for a biological fingerprint relative to new aspects of the relationship between humans and natural environment during prehistoric times is challenging. Although many issues still need to be addressed in terms of authentication and identification, microparticles hidden in ancient dental calculus can provide interesting information for bridging this gap of knowledge. Here, we show evidence about the role of edible plants for the early Neolithic individuals in the central Apennines of the Italian peninsula and relative cultural landscape. Dental calculi from human and animal specimens exhumed at Grotta Mora Cavorso (Lazio), one of the largest prehistoric burial deposits, have returned an archaeobotanical record made up of several types of palaeoecological proxies. The organic fraction of this matrix was investigated by a multidisciplinary approach, whose novelty consisted in the application of next generation sequencing to ancient plant DNA fragments, specifically codifying for maturase K barcode gene. Panicoideae and Triticeae starches, together with genetic indicators of Rosaceae fruits, figs, and Lamiaceae herbs, suggested subsistence practices most likely still based on wild plant resources. On the other hand, pollen, and non-pollen palynomorphs allowed us to outline a general vegetational framework dominated by woodland patches alternated with meadows, where semi-permanent settlements could have been established.
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
Authors: Paterson Helen A. B. , Yu Sijia , Artigas Natalia , Prado Miguel A. , Haberman Nejc , Wang Yi-Fang , Jobbins Andrew M. , Pahita Elena , Mokochinski Joao , Hall Zoe , Guerin Maryse , Paulo Joao A. , Ng Soon Seng , Villarroya Francesc , Rashid Sheikh Tamir , Le Goff Wilfried , Lenhard Boris , Cebola Inês , Finley Daniel , Gygi Steven P. , Sibley Christopher R. , Vernia Santiago 
Published: December 2022

AbstractRNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing factor RNA-binding Fox protein 2 (RBFOX2) in maintaining cholesterol homeostasis in a lipogenic environment in the liver. Using enhanced individual-nucleotide-resolution ultra-violet cross-linking and immunoprecipitation, we identify physiologically relevant targets of RBFOX2 in mouse liver, including the scavenger receptor class B type I (Scarb1). RBFOX2 function is decreased in the liver in diet-induced obesity, causing a Scarb1 isoform switch and alteration of hepatocyte lipid homeostasis. Our findings demonstrate that specific AS programmes actively maintain liver physiology, and underlie the lipotoxic effects of obesogenic diets when dysregulated. Splice-switching oligonucleotides targeting this network alleviate obesity-induced inflammation in the liver and promote an anti-atherogenic lipoprotein profile in the blood, underscoring the potential of isoform-specific RNA therapeutics for treating metabolism-associated diseases.
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity
Authors: Kempf Elena , Landgraf Kathrin , Stein Robert , Hanschkow Martha , Hilbert Anja , Abou Jamra Rami , Boczki Paula , Herberth Gunda , Kühnapfel Andreas , Tseng Yu-Hua , Stäubert Claudia , Schöneberg Torsten , Kühnen Peter , Rayner N. William , Zeggini Eleftheria , Kiess Wieland , Blüher Matthias , Körner Antje 
Published: December 2022

AbstractHere we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places ASIP under control of the ubiquitously active itchy E3 ubiquitin protein ligase promoter, driving the generation of ASIP in patient-derived native and induced pluripotent stem cells for all germ layers and hypothalamic-like neurons. The patient’s phenotype of early-onset obesity, overgrowth, red hair and hyperinsulinemia is concordant with that of mutant mice ubiquitously expressing the homolog nonagouti. ASIP represses melanocyte-stimulating hormone-mediated activation as a melanocortin receptor antagonist, which might affect eating behavior, energy expenditure, adipocyte differentiation and pigmentation, as observed in the index patient. As the type of mutation escapes standard genetic screening algorithms, we rescreened the Leipzig Childhood Obesity cohort of 1,745 patients and identified four additional patients with the identical mutation, ectopic ASIP expression and a similar phenotype. Taken together, our data indicate that ubiquitous ectopic ASIP expression is likely a monogenic cause of human obesity.
VUCA
Authors: Börner Doris , Zohmann Andreas 
Published: December 2022

Liebe Leserin, lieber Leser,haben Sie schon mal von „VUCA“ gehört? VUCA steht für
Volatility (Flüchtigkeit), Uncertainty (Ungewissheit), Complexity
(Komplexität) und Ambiguity (Mehrdeutigkeit). Für eine Welt, die
sich ständig und immer schneller verändert, unvorhersehbar und
volatiler wird. Geprägt von Ungewissheit taugen manch alte Erfahrungen nicht
mehr für die Zukunftsplanung. Wo geht die Reise hin? Wir wissen es nicht
(mehr). Unsere Welt ist komplexer denn je. Die Dinge werden vielschichtiger,
unübersichtlicher und schwerer zu verstehen. Entscheidungen werden
schwieriger. Selten ist etwas eindeutig schwarz oder weiß, oftmals auch
widersprüchlich und paradox und doch „richtig“.
Ambiguitätstoleranz, also die Fähigkeit Vieldeutigkeit und
Unsicherheit zur Kenntnis zu nehmen und ertragen zu können, wird immer
wichtiger.
Veganuary and the vegan sausage (t)rolls: conflict and commercial engagement in online climate-diet discourse
Authors: Sanford Mary , Lorimer Jamie 
Published: December 2022

AbstractSocial media platforms have become critical venues for a wide spectrum of influence campaigns, from activism to advertising. Sometimes these two ends overlap and it remains unknown how the latter might impact the former. Situated within contemporary scholarship on vegan activism, this work examines corporate involvement with the Veganuary 2019 campaign on Twitter, as well as the antagonistic backlash it received. We find that the activists and commercial entities engage mostly separate audiences, suggesting that commercial campaigns do little to drive interactions with Veganuary activism. We also discover strong threads of antagonism reflecting the “culture wars" surrounding discussions of veganism and climate-diet science. These findings inform our understanding of the challenges facing climate-diet discourses on social media and motivate further research into the role of commercial agents in online activism.
The gravitational afterglow of boson stars
Authors: Croft Robin , Helfer Thomas , Ge Bo-Xuan , Radia Miren , Evstafyeva Tamara , Lim Eugene A , Sperhake Ulrich , Clough Katy 
Published: December 2022

Abstract
In this work we study the long-lived post-merger gravitational wave signature of a boson-star binary coalescence. We use full numerical relativity to simulate the post-merger and track the gravitational afterglow over an extended period of time. We implement recent innovations for the binary initial data, which significantly reduce spurious initial excitations of the scalar field profiles, as well as a measure for the angular momentum that allows us to track the total momentum of the spatial volume, including the curvature contribution. Crucially, we find the afterglow to last much longer than the spin-down timescale. This prolonged gravitational wave afterglow provides a characteristic signal that may distinguish it from other astrophysical sources.
Decoupling 1D and 2D features of 2D sp-nanoribbons—the megatom model
Authors: Andriotis Antonis N , Menon Madhu 
Published: December 2022

Abstract
The dependence of the electron energy band gap on the width of an sp-nanoribbon is investigated using a generalization of the 1D tight binding model for a chain of atoms. Within the proposed generalization, small linear atomic formations along lines perpendicular to the 2D ribbon axis are modeled as single large atoms called megatoms whose properties depend on the type, the size and the atomic conformation. Replacement of a 1D chain of atoms by that of the megatoms is accompanied by the incorporation of zeroth order 2D features into the 1D model approximation of the nanoribbon. We use this model to investigate the oscillating band gap of an sp-nanoribbon in terms of the ribbon’s width. Results are presented for the width dependence of the energy gap of the zig-zag Si2BN nanoribbons.
The applications of epigallocatechin gallate (EGCG)-nanogold conjugate in cancer therapy
Authors: Karimi-Shahri Mehdi , Alalikhan Abbas , Hashemian Pedram , Hashemzadeh Alireza , Javid Hossein 
Published: December 2022

Abstract
Cancer has recently increased the death toll worldwide owing to inadequate therapy and decreased drug bioavailability. Long-term and untargeted chemotherapeutic exposure causes toxicity to healthy cells and drug resistance. These challenges necessitate the development of new methods to increase drug efficacy. Nanotechnology is an emerging field in the engineering of new drug delivery platforms. The phytochemical epigallocatechin gallate (EGCG), the main component of green tea extract and its most bioactive component, offers novel approaches to cancer cell eradication. The current review focuses on the nanogold-based carriers containing EGCG, with an emphasis on the chemotherapeutic effects of EGCG in cancer treatment. The nanoscale vehicle may improve the EGCG solubility and bioavailability while overcoming constraints and cellular barriers. This article reviewed the phytochemical EGCG-based gold nanoplatforms and their major anticancer applications, both individually, and in combination therapy in a few cases.
On the green factorization method and supersymmetry
Authors: Tan M Y , Nurisya M S , Zainuddin H 
Published: December 2022

Abstract
The factorization method in operator language formalism and supersymmetric quantum mechanics are vastly studied in literature. The well-known factorization method goes to the early work by Infeld and Hull in 1951. However, a different formalism of factorization method introduced by Green in 1965 is less being considered by the researchers. We show that the Green factorization method, also known as the deductive method, has a connection with supersymmetric quantum mechanics. Some anharmonic quantum systems are discussed by obtaining their analytical expressions for the complete spectrum of bound states and superpotential through the Green factorization method.
Effects on heart rate from direct current block of the stimulated rat vagus nerve
Authors: Bender Shane A , Green David B , Daniels Robert J , Ganocy Stephen P , Bhadra Niloy , Vrabec Tina L 
Published: December 2022

Abstract

Objective. Although electrical vagus nerve stimulation has been shown to augment parasympathetic control of the heart, the effects of electrical conduction block have been less rigorously characterized. Previous experiments have demonstrated that direct current (DC) nerve block can be applied safely and effectively in the autonomic system, but additional information about the system dynamics need to be characterized to successfully deploy DC nerve block to clinical practice. Approach. The dynamics of the heart rate (HR) from DC nerve block of the vagus nerve were measured by stimulating the vagus nerve to lower the HR, and then applying DC block to restore normal rate. DC block achieved rapid, complete block, as well as partial block at lower amplitudes. Main Results. Complete block was also achieved using lower amplitudes, but with a slower induction time. The time for DC to induce complete block was significantly predicted by the amplitude; specifically, the amplitude expressed as a percentage of the current required for a rapid, 60 s induction time. Recovery times after the cessation of DC block could occur both instantly, and after a significant delay. Both blocking duration and injected charge were significant in predicting the delay in recovery to normal conduction. Significance. While these data show that broad features such as induction and recovery can be described well by the DC parameters, more precise features of the HR, such as the exact path of the induction and recoveries, are still undefined. These findings show promise for control of the cardiac autonomic nervous system, with potential to expand to the sympathetic inputs as well.
Network organization of resting-state cerebral hemodynamics and their aliasing contributions measured by functional near-infrared spectroscopy
Authors: Zhang Fan , Khan Ali F , Ding Lei , Yuan Han 
Published: December 2022

Abstract

Objective. Spontaneous fluctuations of cerebral hemodynamics measured by functional magnetic resonance imaging (fMRI) are widely used to study the network organization of the brain. The temporal correlations among the ultra-slow, <0.1 Hz fluctuations across the brain regions are interpreted as functional connectivity maps and used for diagnostics of neurological disorders. However, despite the interest narrowed in the ultra-slow fluctuations, hemodynamic activity that exists beyond the ultra-slow frequency range could contribute to the functional connectivity, which remains unclear. Approach. In the present study, we have measured the brain-wide hemodynamics in the human participants with functional near-infrared spectroscopy (fNIRS) in a whole-head, cap-based and high-density montage at a sampling rate of 6.25 Hz. In addition, we have acquired resting state fMRI scans in the same group of participants for cross-modal evaluation of the connectivity maps. Then fNIRS data were deliberately down-sampled to a typical fMRI sampling rate of ∼0.5 Hz and the resulted differential connectivity maps were subject to a k-means clustering. Main results. Our diffuse optical topographical analysis of fNIRS data have revealed a default mode network (DMN) in the spontaneous deoxygenated and oxygenated hemoglobin changes, which remarkably resemble the same fMRI network derived from participants. Moreover, we have shown that the aliased activities in the down-sampled optical signals have altered the connectivity patterns, resulting in a network organization of aliased functional connectivity in the cerebral hemodynamics. Significance. The results have for the first time demonstrated that fNIRS as a broadly accessible modality can image the resting-state functional connectivity in the posterior midline, prefrontal and parietal structures of the DMN in the human brain, in a consistent pattern with fMRI. Further empowered by the fast sampling rate of fNIRS, our findings suggest the presence of aliased connectivity in the current understanding of the human brain organization.
Electromagnetic compatibility technologies based on multi-functional spoof surface plasmon polariton channels
Authors: Niu Ling Yun , Zhang Hao Chi , He Pei Hang , Fan Yi , Zhang Le Peng , Cui Tie Jun 
Published: December 2022

Abstract
High integration of modern microwave circuits and systems puts forward higher requirements for multi-function and electromagnetic compatibility (EMC) performance of transmission channels. In this paper, we propose two EMC technologies including the substrate integrated packaging (SIP) and tuneable wavenumber mismatching (TWM) based on multi-functional spoof surface plasmon polariton (SSPP) channels. The SIP technology can effectively improve the EMC performance of the SSPP channels in the whole frequency band by designing the packaging structure with easy fabrication and compact size; while the TWM technology can significantly suppress crosstalks in desired frequency bands by manipulating the wavenumber difference between two adjacent channels. Simulated and measured results demonstrate excellent multi-function and EMC performance of the integrated multi-functional SSPP channels by employing the two EMC technologies. The integrated multi-functional SSPP channels can realize continuous phase modulation in X-band and continuous amplitude modulation in Ku-band. The coupling coefficient of the integrated channels is about 8–10 dB lower than that of the channels without the package, and is 13–15 dB lower than that of the traditional microstrip channels in the whole X-band and Ku-band. Meanwhile, the coupling coefficient of the integrated multi-functional SSPP channels with a distance of 1/30 λ
0 can be reduced to around −30 dB in the desired narrow bands. Therefore, the proposed EMC technologies may find broad applications in highly integrated microwave circuits and systems.