bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preimplantation genetic testing for aneuploidy in severe male factor infertility: protocol for a multicenter randomised controlled trial
Authors: Lin Xian-hua , Guo Meng-xi , Wu Dan-dan , Lu Yao , Zhang Jian-lin , Zhou Cheng-liang , Jin Li , Wang Li , Zhang Chen , Xu Chen-ming , Chen Song-chang , Zhang Song-ying , Sun Xiao-xi , Wu Yan-ting , Sun Yun , Huang He-feng 
Published: July 2022

IntroductionConventional intracytoplasmic sperm injection (ICSI) is a widely used treatment for couples with severe male infertility. However, there are controversies regarding the selection and the damage to gametes during the ICSI procedure. Although preimplantation genetic testing for aneuploidies (PGT-A) can give genetic information about embryos for transfer and improve fertility rate, and it is widely used in women with recurrent spontaneous abortion or advanced age, PGT-A is not only more expensive but also has unclear effectiveness with respect to the improvement of fertility rate among couples with severe male infertility. High-quality, well-powered randomised clinical trials (RCTs) comparing ICSI+PGT-A and ICSI are lacking.Methods and analysisThis is a protocol for a multicenter, open-label RCT in four reproductive medical centers qualified for PGT technique in China. We will study couples with severe male infertility scheduled for their fertility treatment. After the blastocyst culture, eligible participants are randomised to the ICSI+PGT-A group or the conventional ICSI group in a 1:1 ratio. Other assisted reproductive procedures are similar and parallel between the two groups. The primary outcome will be live birth rate and cumulative live-birth rate . Secondary outcomes will be embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, spontaneous abortion rate, ongoing pregnancy rate, preterm birth rate, fetal chromosomal abnormality rate, birth defect rate and treatment complications. To demonstrate or refute a difference between the two groups, we plan to include 188 participants in each group; taking consideration of 20% of dropout, the total target sample size is 450.Ethics and disseminationEthical approval was obtained from International Peace Maternity and Child Health Hospital of Shanghai Jiao Tong University Medical Science Research Ethics Committee (GKLW2016-16). Informed consent will be obtained from each participant. The findings will be disseminated to the public through conference presentations and publication in peer-reviewed scientific journals.Trial registration numberClinicalTrials.gov, NCT02941965.
Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake
Authors: Collatuzzo Giulia , Alicandro Gianfranco , Bertuccio Paola , Pelucchi Claudio , Bonzi Rossella , Palli Domenico , Ferraroni Monica , Ye Weimin , Plymoth Amelie , Zaridze David , Maximovich Dmitry , Aragones Nuria , Castaño-Vinyals Gemma , Vioque Jesus , Garcia de la Hera Manoli , Zhang Zuo-Feng , Hu Jinfu , Lopez-Carrillo Lizbeth , López-Cervantes Malaquías , Dalmartello Michela , Mu Lina , Ward Mary H , Rabkin Charles , Yu Guo-Pei , Camargo M Constanza , Curado Maria Paula , Lunet Nuno , Negri Eva , La Vecchia Carlo , Boffetta Paolo 
Published: July 2022

BackgroundPeptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC.MethodsWe conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC.ResultsPUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC.ConclusionsOur study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.
Drug prescribing changes in the last year of life among homebound older adults: national retrospective cohort study
Authors: Hattori Yukari , Hamada Shota , Yamanaka Takashi , Kidana Kiwami , Iwagami Masao , Sakata Nobuo , Tamiya Nanako , Kojima Taro , Ogawa Sumito , Akishita Masahiro 
Published: July 2022

ObjectivesThis study aimed to evaluate the prescription patterns of drugs during the last year of life in homebound older adults who received home medical care.MethodsWe used a nationwide claims database in Japan and selected older adults aged ≥75 years who received home medical care services from ≥12 months before their death. We evaluated medications prescribed 12 months before death (month 12), 3 months before death (month 3) and in the last month of life (month 1). We explored the factors associated with the decreased number of cardiovascular preventive drugs from month 12 to both month 3 and month 1.ResultsA total of 118 661 participants were included, and the majority were aged ≥90 years and women. The prevalence of cardiovascular preventive drugs decreased but remained common in month 1, which included antihypertensives (34.7%), antiplatelets (15.9%), oral anticoagulants (7.6%), antidiabetic drugs (7.3%) and lipid-lowering drugs (6.1%). The relative decrease from month 12 to month 1 was the largest for lipid-lowering drugs (44.8%) and the smallest for oral anticoagulants (13.6%). Among other drugs, laxatives (enema), antiemetics, oral corticosteroids, analgesics, expectorants, bronchodilators and antibiotics showed a large relative increase. Older age, duration of home medical care services for <1 year and diagnoses of cancer, dementia and Parkinson’s disease were associated with a greater likelihood of a decreased number of cardiovascular preventive drugs.ConclusionsThere is room for deprescribing to avoid inappropriate polypharmacy by balancing preventive and symptom management drugs in those receiving home medical care with a limited life expectancy.
A re-evaluation of conflicting taxonomic structures of EurasianTriaenophorusspp. (Cestoda, Bothriocephalidea: Triaenophoridae) based on partialcox1mtDNA and 28S rRNA gene sequences
Authors: Vlasenko Pavel G. , Sokolov Sergey G. , Ieshko Evgeny P. , Frolov Evgeniy V. , Kalmykov Alexander P. , Parshukov Aleksey N. , Chugunova Yulia K. , Kashinskaya Elena N. , Shokurova Anastasiya V. , Bochkarev Nikolai A. , Andree Karl B. , Solovyev Mikhail M. 
Published: July 2022

Cestodes of the genus Triaenophorus Rudolphi, 1793 are widely distributed parasites of Esocidae, Percidae, Salmonidae, Thimallidae, Cobitidae, Osmeridae, Cyprinidae, Cottiidae, Lotidae, and several others in the Holarctic. The taxonomic arrangements of different authors, based on morphological and ecological–biogeographic characters, suggest the presence of two to five species of this genus in Eurasia. The genetic variation of Eurasian Triaenophorus spp. was evaluated using DNA barcoding ( cox1 and 28S gene sequences). This confirmed the validity of five Triaenophorus species: T. amurensis, T. crassus, T. meridionalis, T. nodulosus, and T. orientalis. We demonstrated systematic concordance between traditional meristic criteria and DNA sequence data. Phylogenetic reconstructions support the monophyletic origin of the group of species with a long basal plate of the scolex hook ( T. crassus, T. meridionalis, and T. orientalis). Triaenophorus crassus is represented by two haplogroups, associated with Siberia and northwestern Russia. Our results show differences between T. nodulosus, T. amurensis, and T. crassus in terms of the haplotype diversity level, which are probably related to the Quaternary history of the development of their ranges, as well as the degree of euryxeny to the second intermediate host.
Combined effects of cold snaps and agriculture on the growth rates of Tree Swallows (Tachycineta bicolor)
Authors: Garrett Daniel R. , Lamoureux Stéphane , Rioux Paquette Sébastien , Pelletier Fanie , Garant Dany , Bélisle Marc 
Published: July 2022

The decline of avian aerial insectivores has been greater than any other foraging guild and both climate change and agricultural intensification are leading hypotheses explaining this decline. Spring cold snaps are predicted to increase in frequency due to climate change, and factors associated with agricultural intensification (e.g., toxicological agents, simplification of agricultural landscapes, and reductions of insect prey) potentially exacerbates the negative effects of cold snaps on aerial insectivore nestling growth and body condition. We evaluated this hypothesis using repeated measures of Tree Swallow ( Tachycineta bicolor (Vieillot, 1808)) nestling body mass and 9th primary length across an expansive gradient of agricultural intensification. Growth rate, asymptotic body mass, and near-fledging 9th primary length were lower for nestlings in landscapes consisting of more agro-intensive monocultures. This 14-year dataset of body measures occurring at 2, 6, 12, and 16 days of age showed that the negative impact of cold snaps on the growth of these two traits was stronger for nestlings reared in more agro-intensive landscapes. Our findings provide further evidence that two of the primary hypothesized drivers for the decline of many aerial insectivores may interact and aggravate their decline by reducing fledging survival.
CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II
Authors: Sun Yilun , Zhang Yang , Schultz Christopher W. , Pommier Yves , Thomas Anish 
Published: July 2022

Abstract
Small cell lung cancers (SCLC) are highly aggressive, and currently there are no available targeted therapies. To identify clinically actionable drug combinations, we analyzed our previously reported chemogenomics screens and identified a synergistically cytotoxic combination of the topoisomerase I (TOP1) inhibitor topotecan and cycle-dependent kinase 7 (CDK7) inhibitor THZ1. Topotecan causes cell death by generating TOP1-induced DNA breaks and DNA-protein cross-links (TOP1-DPC) that require proteolysis by the ubiquitin-proteasome pathway for their repair. We find that inhibition of the transcriptional kinase CDK7 by THZ1 induces ubiquitin-mediated proteasomal degradation of RNA polymerase II and prevents the proteasomal degradation of TOP1-DPCs. We provide a mechanistic basis for combinatorial targeting of transcription using selective inhibitors of CDK7 and TOP1 in clinical trials to advance SCLC therapeutics.
Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer
Authors: Sokač Mateo , Ahrenfeldt Johanne , Litchfield Kevin , Watkins Thomas B.K. , Knudsen Michael , Dyrskjøt Lars , Jakobsen Martin R. , Birkbak Nicolai J. 
Published: July 2022

The cGAS-STING pathway serves a critical role in anticancer therapy. Particularly, response to immunotherapy is likely driven by both active cGAS-STING signaling that attracts immune cells, and by the presence of cancer neoantigens that presents as targets for cytotoxic T cells. Chromosomal instability (CIN) is a hallmark of cancer, but also leads to an accumulation of cytosolic DNA that in turn results in increased cGAS-STING signaling. To avoid triggering the cGAS-STING pathway, it is commonly disrupted by cancer cells, either through mutations in the pathway or through transcriptional silencing. Given its effect on the immune system, determining the cGAS-STING activation status prior to treatment initiation is likely of clinical relevance. Here, we used combined expression data from 2,307 tumors from five cancer types from The Cancer Genome Atlas to define a novel cGAS-STING activity score based on eight genes with a known role in the pathway. Using unsupervised clustering, four distinct categories of cGAS-STING activation were identified. In multivariate models, the cGAS-STING active tumors show improved prognosis. Importantly, in an independent bladder cancer immunotherapy-treated cohort, patients with low cGAS-STING expression showed limited response to treatment, while patients with high expression showed improved response and prognosis, particularly among patients with high CIN and more neoantigens. In a multivariate model, a significant interaction was observed between CIN, neoantigens, and cGAS-STING activation. Together, this suggests a potential role of cGAS-STING activity as a predictive biomarker for the application of immunotherapy.Significance:The cGAS-STING pathway is induced by CIN, triggers inflammation and is often deficient in cancer. We provide a tool to evaluate cGAS-STING activity and demonstrate clinical significance in immunotherapy response.
Playing with the Ancients: The Cosmology of Gilles Personne de Roberval
Authors: Babeş Ovidiu 
Published: July 2022

Abstract
This contribution explores Gilles Personne de Roberval’s 1644 Aristarchi Samii de mundi systemate, partibus, & motibus eiusdem, libellus. I focus on the complex circumstances of publication, the intellectual context of the polemics of Copernicanism within the scientific community, as well as the natural philosophy of the treatise. Roberval’s strategy of publication provides a very sophisticated example of authorship in early modern natural philosophy. The strategy lies at the conflux of certain specific motivations. I contextualize these motivations by accounting for the delicate debates around the motion of the Earth in mid-seventeenth century Europe, the institutional communities of the Collège Royal and Mersenne’s circle, and the disciplinary bounds of Roberval’s professional authority. Weighing in all the elements, I argue that Roberval’s publication is an interesting intellectual game, playing with the notion of ancient authority and humanistic recovery. By this somewhat libertine attitude, Roberval takes a stance in a complicated debate around heliocentrism and the status of hypothetical cosmology. Roberval’s position is supported by his natural philosophical speculations, which I situate in the contemporary debates of the community. Roberval borrows from many philosophers, but he aims at achieving a highly systematic speculative cosmology. One of the functions of this system is to confirm Copernicanism, while maintaining a very pessimistic attitude on the prospects of precise astronomical knowledge and, among others, prognostication issues.
‘Our Three Selves:’ Radclyffe Hall and Mabel Batten’s Lived Catholicism
Authors: Lamontagne Kathryn G. 
Published: July 2022

Abstract
For British Catholic women, conversion was an empowering choice for oneself, rather than a path towards gaining institutionalized power. Lay female converts at the turn of the century were generally privileged, with a worldly understanding of the role of women in British society. Many converts drew on the spirit of female independence at the end of the 19th century to contest their place in British society. For some, their social and financial capital offered an additional position of power from which to push on notions of traditional Britishness and femininity. To have the freedom to choose conversion at all exemplifies this feeling of bodily and mental autonomy rarely exhibited by many women during the late 19th century and early 20th century. This article sheds new light on the expansiveness of the lived, lay Catholic experience in Britain in the late 19th and early 20th centuries through the examples of Mabel Batten (1857–1916) and Radclyffe Hall (1880–1943).
The Lived Contestations of Adivasi Catholic Identity-Making
Authors: D’Souza Rinald 
Published: July 2022

Abstract
In the mid-nineteenth century movement towards Christianity in Chotanagpur in central India, the missionary Constant Lievens (1856–1893) played a pioneering role in the establishment of the Catholic Mission among the Adivasis (indigenous peoples). Through Lievens’ legal advocacy, Adivasis not only adopted a faith, but also began to reclaim their lands and their indigeneity. Drawing on ethnographic research around the intercessory prayer for the beatification of Lievens, this paper analyses the present-day lived contestations of Adivasi Catholic identity-making. The paper argues that Adivasi Catholic identities are lived in contestation and continuous negotiation with their present realities, while also borrowing from the legacies of their own past struggles and their intermediaries.
Beyond Algorithmic Control: Ordering and Delivery Platforms Labor Process in the Chilean Retail Production Network
Authors: Boccardo Giorgio , Castillo Alejandro , Ojeda-Pereira Iván 
Published: July 2022

Abstract
This article describes and analyzes the labor process of Rappi, one of the main ordering and delivery platforms (odp) in Latin America. An exploratory qualitative case study was carried out and the results are based on the content analysis of 20 semi-structured interviews to platform workers as well as ethnographic work done in 2019–2020 in Santiago de Chile. This article contributes to, first, describe and analyze labor processes organized by an odp whose property and operation is managed in the Global South; second, it enables to explore the role played by Rappi within the Chilean retail production network; third, it connects diverse labor processes organized by odp s further on the ‘pick-up and deliver’ orders task; finally, it analyzes different control mechanisms executed by Rappi beyond algorithmic control, together with individual and collective resistance practices adopted by shoppers and riders.
24/7 Digital Work-Based Spy: The Effects of Technological Panopticism on Workers in the Digital Age
Authors: Duke Benjamin 
Published: July 2022

Abstract
This paper is delivered from a conceptual theoretical review of grey literature: identifying key concepts and pragmatic policy interventions, which are required to address various aspects of the digital workforce. The main objective and purpose of this study is to analyze then articulate how technological panopticism, digital surveillance has changed the world of work. The study alerts us to the significant changes in work relations, which have been imposed by the digital age. At a nascent level society is asked to consider; how prepared are we to address the effects of technological panopticism on the mental (and physical) wellbeing of digital workers. On a nuanced basis the study fulfils another societal role: acting to introduce consideration of the digital surveillance aspects of how interaction with artificial intelligence and/or the internet of things could develop in the 2020s.
Joseph’s Hyper-Assimilation: A Fourth Generation’s Hidden Memory of Collapse
Authors: Ahn John 
Published: July 2022

Abstract
This essay, compromised of six parts, discusses: (1) migration and generation consciousness, (2) the framing of Gen 12–50 and Exodus to 2 Kings through the socio-canonical cadre of four generations, (3) the theological nature of the Southern Kingdom’s fall—sin, a first generation exilic construct, (4) the third generation in Jacob, (5) the fourth generation Joseph and its most telling subject matter of a hidden cultural memory, and (6) the conclusion comparing the third and fourth generations respectively, for further scholastic engagement. Seminal subject matters from Elephantine are also discussed.
Rethinking the Parables of Luke 15: A Case for the Fourth Parable
Authors: Melbourne Bertram 
Published: July 2022

Abstract
This article explores separating the two sections that make up the third parable to explore whether the second of the two could constitute a fourth parable that has its own unique message and therefore could stand alone. Moreover, all four parables are compared to see whether or not there are common features and/or patterns that could exhibit the intent of the storyteller. My thesis is that Luke 15 has four parables. This notion is supported structurally, thematically and is consistent with Jesus’ teaching methodology and his theology. I propose that when we limit it to three, we inadvertently legitimize the thoughts, actions, and feelings of the elder brother, weaken the contrast and thereby dullen the message Jesus sought to convey to his hearers.
Establishing a Just Society through a Qur’anic Lens
Authors: Alwani Zainab 
Published: July 2022

Abstract
This article examines the methods and strategies introduced by the Qur’an for establishing a just society. More specifically, it argues that the opening verse of Surat al-Nisa (the fourth chapter of the Qur’an) serves as a roadmap for humanity on how to achieve true peace, establish authentic justice and maintain sustainable security in every aspect of life. In doing so, the article addresses the following questions: What does the Qur’an mean when it states that humanity is one family?
What should be done to affirm every person’s dignity and respect is preserved? How can we secure justice and establish peace for all people? What are the measures that should be considered to evaluate our success or failure strategies? The article engages with these critical issues through the lens of the Quran, applying the methodology of reading the Qur’an intratextually as one structural unity (al-wihda al-binaʾiyya lil-Qur’an). This holistic method reads the Qur’an as a unified text by cross-examining and integrating its linguistic, structural, and conceptual elements. The article highlights the Qur’anic model to prevent injustice and promote peace through justice and mercy by being individually accountable to each other.
Cone and Cannon: Black Theology and Visions of Society
Authors: James Leslie R. 
Published: July 2022

Abstract
This essay inspired by the memory of James H. Cone (1938–2018) and Katie G. Cannon (1950–2018), explores the contributions of both scholars to the academy, society, and the public space. Drawing on selected publications, it argues that the recent “passing over” of these two liberationist theologians to other shores of existence warrant significant reflection on their legacies in combating social and other forms of death, reimagining black historical, communal, and eschatological existence, and visions of liberation, justice, and peace for all. They articulated an idea or vision of American society that ran counter to and sought to transcend the dominant construction or ethos of American society.