bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Cytokine Profiles in Human THP-1 Cells during Phase Transition of Talaromyces marneffei
Authors: Shu Fangyi , Thammasit Patcharin , Pruksaphon Kritsada , Nosanchuk Joshua D. , Youngchim Sirida 
Published: December 2022

Talaromyces marneffei, a dimorphic fungus, exhibits temperature-dependent growth, existing in a filamentous form at 25 °C and as a yeast at 37 °C. Several studies have highlighted the important roles of macrophages in defense against T. marneffei infection. However, the immune responses to the interaction of macrophages with T. marneffei cells during phase transition require further investigation. This study reports the expression of cytokine profiles in human THP-1 cells during infection by T. marneffei. THP-1 cells were infected with T. marneffei conidia at different multiplicity of infections (MOIs). Surviving conidia transformed into yeasts after phagocytosis by macrophages, and the number of yeasts gradually increased over 36 h. The transcription and secretion levels of pro- and anti-inflammatory cytokines were examined at different times by qRT-PCR and ELISA. Transcription levels of IL-8, IL-12, IL-1β, and TNF-α increased significantly at 12 or 24 h and then slightly decreased at 36 h. In contrast, the transcription levels of IL-6, IL-10, and TGF-β gradually increased at all MOIs. The levels of IL-6 and IL-10 secretion corresponded to their levels of transcription. These results indicated that as the number of intracellular yeasts increased, the infected macrophages first underwent slight M1 polarization before shifting to M2 polarization. This polarization transition was confirmed by the fungicidal ability and the expression of macrophage surface markers. By inducing the M2-type polarization of macrophages, the intracellular T. marneffei cells can successfully evade the immune response. Our study provides a novel insight into the immune characterization during the transition of T. marneffei infection and could further contribute to possible diagnostic and therapeutic interventions for this infection.
Storm-Time Relative Total Electron Content Modelling Using Machine Learning Techniques
Authors: Adolfs Marjolijn , Hoque Mohammed Mainul , Shprits Yuri Y. 
Published: December 2022

Accurately predicting total electron content (TEC) during geomagnetic storms is still a challenging task for ionospheric models. In this work, a neural-network (NN)-based model is proposed which predicts relative TEC with respect to the preceding 27-day median TEC, during storm time for the European region (with longitudes 30°W–50°E and latitudes 32.5°N–70°N). The 27-day median TEC (referred to as median TEC), latitude, longitude, universal time, storm time, solar radio flux index F10.7, global storm index SYM-H and geomagnetic activity index Hp30 are used as inputs and the output of the network is the relative TEC. The relative TEC can be converted to the actual TEC knowing the median TEC. The median TEC is calculated at each grid point over the European region considering data from the last 27 days before the storm using global ionosphere maps (GIMs) from international GNSS service (IGS) sources. A storm event is defined when the storm time disturbance index Dst drops below 50 nanotesla. The model was trained with storm-time relative TEC data from the time period of 1998 until 2019 (2015 is excluded) and contains 365 storms. Unseen storm data from 33 storm events during 2015 and 2020 were used to test the model. The UQRG GIMs were used because of their high temporal resolution (15 min) compared to other products from different analysis centers. The NN-based model predictions show the seasonal behavior of the storms including positive and negative storm phases during winter and summer, respectively, and show a mixture of both phases during equinoxes. The model’s performance was also compared with the Neustrelitz TEC model (NTCM) and the NN-based quiet-time TEC model, both developed at the German Aerospace Agency (DLR). The storm model has a root mean squared error (RMSE) of 3.38 TEC units (TECU), which is an improvement by 1.87 TECU compared to the NTCM, where an RMSE of 5.25 TECU was found. This improvement corresponds to a performance increase by 35.6%. The storm-time model outperforms the quiet-time model by 1.34 TECU, which corresponds to a performance increase by 28.4% from 4.72 to 3.38 TECU. The quiet-time model was trained with Carrington averaged TEC and, therefore, is ideal to be used as an input instead of the GIM derived 27-day median. We found an improvement by 0.8 TECU which corresponds to a performance increase by 17% from 4.72 to 3.92 TECU for the storm-time model using the quiet-time-model predicted TEC as an input compared to solely using the quiet-time model.
Indicadores de qualidade de vida no trabalho de docentes de instituições federais de ensino superior das regiões sudeste, centro-oeste e Distrito Federal / Quality of life indicators in the work of teachers from federal higher education institutions in the southeast, midwest and Federal District
Authors: Boas Ana Alice Vilas , Pires Ana Alice de Sousa , Faria Danuza Adriane , Morin Estelle M. 
Published: December 2022

A carreira docente no ensino superior que já foi muito almejada, vem sofrendo com a precarização das condições de trabalho que pode ser observada no produtivismo, no excesso de atividades administrativas que os docentes precisam realizar e na precariedade de algumas instituições. Tendo em vista que os profissionais buscam a Qualidade de Vida no Trabalho (QVT) como uma forma de obter uma sensação de bem-estar no local de trabalho, essa situação compromete a QVT desses profissionais. A QVT é um conceito complexo, que combina dois aspectos principais: os fatores - determinantes da QVT - e os indicadores - componentes de QVT. Neste estudo vamos analisar os indicadores: sentido do trabalho, sentido no trabalho, comprometimento organizacional, bem-estar psicológico, sofrimento psicológico, burnout, comprometimento com o trabalho, estresse relacionado ao trabalho, equilíbrio vida-trabalho e presenteísmo.O presente estudo quantitativo faz uma análise desses indicadores de qualidade de vida no trabalho de instituições federais de ensino superior localizadas nas regiões Sudeste (exceto MG e ES), Centro-Oeste e Distrito Federal. Os dados foram coletados através de um questionário on-line enviado via Survey Monkey para os e-mails dos docentes que foram coletados dos sites das instituições, no ano de 2016. Os dados foram analisados no SPSS versão 2.1. Os resultados obtidos através das análises mostram que o inter-relacionamento entre os indicadores são consistentes. Quando esses são bem compreendidos e trabalhados, eles podem proporcionar ganhos para as organizações e para os próprios indivíduos. O inter-relacionamento entre os indicadores de QVT encontrado nesta pesquisa mostram que os resultados são consistentes com outra pesquisa comparativa entre professores brasileiros e canadenses e que os coeficientes dos indicadores são coerentes com os construtos aparentes que mostram a relevância dos indicadores de Sentido do Trabalho e do Sentido no Trabalho para se entender melhor os padrões de qualidade de vida no trabalho (VILAS BOAS e MORIN, 2017, 2016, 2013). A comparação de medias de amostras independentes mostra que as mulheres apresentam mais estresse relacionado ao trabalho, mais sofrimento psicológico, mais burnout e mais presenteísmo, enquanto que os homens apresentam mais bem-estar psicológico e mais e equilíbrio vida/trabalho. Em suma, pode-se afirmar que a promoção da qualidade de vida no trabalho deve ser um conjunto de atividades para promover um ambiente de trabalho saudável e um trabalho que faz sentido ao indivíduo, por isso lidar com estes indicadores e de extrema importância para melhorar o ambiente organizacional e os mesmos devem ser observado pelos gestores públicos.
Concepção e influência da liga acadêmica de geotecnia (LAG) no curso de engenharia civil da PUC-MG / Conception and influence of the academic geotechnical league (LAG) in the civil engineering course of PUC-MG
Authors: Silva Luan Domingues da , Silva Mariana Alvarenga Ruas e , Resende André Matoso , Paula Mhaisa Henrique de , Bonaldo Everaldo 
Published: December 2022

O curso de engenharia civil é a modalidade da engenharia o qual possuiu a segunda maior quantidade de concluintes em 2011 no Brasil. Este alto contingente de novos engenheiros foi possivelmente absorvido pela indústria da construção civil, sobretudo devido ao momento econômico ascendente em que o país encontrava-se e à participação do Brasil como país sede da copa e das olimpíadas. Também, em 2011, o curso de engenharia civil apresentou a maior quantidade de ingressantes dentre as engenharias, sendo também um dos cursos mais concorridos. Esta alta demanda pelo curso, concomitante a crise de 2015 repercutiram na escassez de empregos no mercado de trabalho em todas as subáreas da engenharia civil, inclusive no setor de geotecnia cuja aplicação normalmente é limitada durante os cursos de graduação. Este fator somado ao desinteresse dos discentes resulta em um baixo contingente de mão de obra qualificada e jovem para obras de geotecnia, tornando-a uma área majoritariamente integrada por engenheiros mais experientes. Tais fatores impulsionaram estudantes de graduação do curso de engenharia civil da Pontifícia Universidade Católica de Minas Gerais (PUC-MG) à criação da Liga Acadêmica de Geotecnia (LAG) com o propósito de desenvolver atividades acadêmicas, científicas e extensivas a fim de aprimoramento e maior preparação tanto para a esfera profissional, quanto para o âmbito acadêmico. Portanto, este artigo apresenta a concepção da liga acadêmica de Engenharia Civil na PUC-MG unidade Barreiro e as principais mudanças que este grupo já estimulou na formação dos estudantes e até mesmo na qualidade do curso.
ANALOGI PEREMPUAN DALAM PERKEMBANGAN ARSITEKTUR VERNAKULAR DI SULAWESI SELATAN
Authors: Hildayanti Andi 
Published: December 2022

In the vernacular architecture development, the female body size has been used as a basis for determining the room size in the building. The existing forms appreciation manifested in domain forms, space functions, materials, and ornaments. The female gender elements, both in terms of body anatomy and special room, are applied as a form of reflection the traditional identity house. One of the traditional houses that applies gender roles as an architectural philosophy is the Karampuang Traditional House which is located in Sinjai Regency, South Sulawesi. This study discusses the role of women as the basis for the philosophy and architectural symbolism of the Karampuang Traditional House. The analytical method used is descriptive analysis interpretation based on the architectural components found in the Karampuang house data. The results showed that complexity of female gender which cannot be separated from the nature of women and the history of Karampuang where the first person to build and prosper Karampuang is a woman. The use and placement of symbols on parts and ornaments of the house represents the female body anatomy. The female gender is more dominant in the traditional Karampuang house. Aspects based on gender in the Karampuang traditional house are influenced by the history believed by the community, and female gender elements both in terms of body anatomy, as well as a special room for women are applied in their traditional houses. In the context of preserving traditional houses and regional culture, especially in Karampuang, serious attention is needed both by the people themselves and by the government in an effort to protect, maintain, and maintain the uniqueness of Karampuang architecture.
STANDAR PENGELOLAAN PENDIDIKAN MA BPII (BADAN PERGURUAN ISLAM INDONESIA) PAMBOANG DALAM PERSPEKTIF MANAJEMEN BERBASIS SEKOLAH DAN MANAJEMEN MUTU TERPADU
Authors: Nurfitri Nurfitri 
Published: December 2022

The study aimed to reflect the implementation of the standard for management of education in a shool-based and integrated quality management perspective in MA BPII (Indonesian Islamic School) Pamboang. The study used a type of qualitative research with an approach to case studies. The object of this study was carried out in ma bpii (the Indonesian islamic school) Pamboang. Data collection techniques used observation, interviews, and documentation. The data sources in the study included the headmaster, curriculum section vice principal, students, publicists, sarpras, committee and students. The analysis techniques used in the study are data collecting, data reduction, data presentation, deduction. The triangulation used to test the validity of data is source triangulation.Research showed that the management of education in MA BPII Pamboang was established from the decision of the head of the school to manage education in MA BPII Pamboang, from the independence of the principal to take decisions in curriculum and student classes, the participation of all schoolchildren from the principal, teacher, and teacher. The education and education participants have a crucial share in all of the activities that are available in MA BPII Pamboang, where school management was conducted according to each other's ability, and the principal gives all schoolchildren an opportunity to make an opinion to improve the quality of education ma bpii pamboang. Integrated quality management in MA BPII (Indonesia islamic School) researcher found that it had not fully applied integrated quality management, as shown by studies that researcher had found only 5 integrated quality management principles from 8 existing ones.
EKSISTENSI PEMUDA DALAM PEMBERDAYAAN WISATA ALAM DI DESA PAPPANDANGAN KECAMATAN ANREAPI KABUPATEN POLEWALI MANDAR
Authors: Parawansa Aco , IR Rustan , Wawan Nelson 
Published: December 2022

Tujuan penelitian ini adalah untuk mendeskripsikan eksistensi pemuda dalam pemberdayaan wisata alam di Desa Pappandangan dan untuk mengetahui faktor pendukung dan penghambat yang berpengaruh terhadap eksistensi pemuda pemuda dalam pemberdayaan wisata alam di Desa Pappandangan Kecamatan Anreapi Kabupaten Polewali Mandar. Penelitian ini menggunakan pendekatan kualitatif yang hasilnya disajikan secara deskriptif. Pengumpulan data dilakukan dengan teknik observasi, wawancara, dan dokumentasi dengan subjek penelitian adalah pengelola, pemuda, tokoh masyarakat, dan masyarakat sekitar di Desa Pappandangan. Pembuktian keabsahan data menggunakan triangulasi sumber dan metode. Analisis data yang digunakan adalah analisis kualitatif dengan langkah pengumpulan data, reduksi data, display data, dan penarikan kesimpulan. Hasil penelitian yang diperoleh dalam penelitian ini adalah : (1) Eksistensi pemuda dalam pemberdayaan wisata alam adalah sebagai obyek, bukan sebagai subyek, yang ditandai dengan: (a) tidak terdapat partisipasi pemuda dalam pembuatan dan pengambilan keputusan dalam rencana-rencana yang biasa dilaksanakan karena inisiatif setiap program tidak muncul dari pemuda tapi dari pengurusnya. (b) partisipasi pemuda dalam implementasi dan pelaksanaan. Pemuda terlibat pada beberapa kegiatan desa wisata, yaitu outbound, permainan anak, kegiatan api unggun, dan kesenian jathilan dan gejug lesung. (c) partisipasi pemuda dalam menikmati hasil kegiatan yang memberikan keuntungan pada segi keuangan pemuda dan kekompakan di masyarakat. (2) Faktor pendukung pemuda dalam Pemberdayaan Wisata Alam desa Pappandangan antara lain: semangat, faktor pengangguran, dan faktor masyarakat. Sedangkan faktor penghambatnya antara lain: Eksistensi pemuda belum maksimal, dan kurangnya dana atau pemasukan dari pemerintah daerah.
estudos geomorfológicos no Brasil
Authors: Oliveira Maria Dione do Nascimento Oliveira , Almeida Maria Ivete Soares de Almeida 
Published: December 2022

Este artigo discute o processo de institucionalização do ensino de Geografia nas universidades brasileiras na primeira metade do século XX e sua importância para o desenvolvimento e consolidação da pesquisa geomorfológica nacional. A metodologia adotada constou de revisão bibliográfica. Os estudos geomorfológicos no Brasil surgiram nas primeiras décadas do século XX em consonância com a institucionalização do ensino de Geografia nas universidades. Nesse processo foi determinante a participação de geógrafos franceses como Pierre Monbeig, Pierre Deffontaines e Emanuel de Martonne. Os primeiros trabalhos, realizados sob a perspectiva da teoria do Ciclo Geográfico da Erosão, ainda que apresentassem inconsistências em seu modelo de evolução geomorfológica, contribuiram significativamente para o desenvolvimento de teorias mais condizentes com a realidade tropical do território brasileiro. A difusão da Geografia alemã, principalmente através das ideias de Walter Penk (1924), foi de grande importância da para a construção de novos modelos interpretativos do relevo. Ressalta-se que a consolidação das bases metodológicas da pesquisa geomorfológica no Brasil ocorreu a partir da década de 1950 com o reconhecimento da importância dos estudos do clima na modelagem do relevo, o desenvolvimento da Cartografia Geomorfológica e o uso do Sensoriamento Remoto nos estudos do território.
Analisis Kelayakan Investasi Sistem Penyediaan Air Minum (SPAM) Di Desa Wanagiri, Kecamatan Sukasada, Kabupaten Buleleng
Authors: Diasa I Wayan , Heka Ardana Putu Doddy , Widarmawa I Ketut , Pamungkas Tri Hayatining 
Published: December 2022

Penyediaan air minum di Kabupaten Buleleng dilakukan melalui Sistem Perusahaan Daerah Air Minum (PDAM) dan Sistem Swakelola Masyarakat dalam bentuk Lembaga Unit Pengelola Sarana atau Kelompok Pengelola Sarana (UPS/KPS) ditingkat desa/kelompok. Namun di beberapa tempat di daerah Kabupaten Buleleng layanan PDAM Buleleng belum bisa memberikan pelayanan karena disebabkan oleh topografi wilayah kabupaten Buleleng yang berbukit, pemukiman penduduk yang menyebar dan potensi sumber air yang tidak merata. Desa wanagiri merupakan salah satu desa yang belum terlayani oleh PDAM Buleleng. Dalam tugas akhir ini, akan dilakukan Analisis yang bertujuan untuk mengetahui Kelayakan Sistem Penyediaan Air Minum yang nantinya diharapkan dapat menjadi acuan maupun alternatif dalam pemenuhan kebutuhan air di Desa Wanagiri. Penelitian ini mengumpulkan data yang berupa Data Sekunder berupa Peta Wilayah, Jumlah penduduk, Harga satuan upah dan bahan bangunan serta harga pompa dan perpipaan, sedangkan data primer yang digunakan yaitu debit air, letak Broncaptering, letak Reservoir Transmisi, letak Reservoir Distribusi, Beda tinggi (head), Letak rumah pompa dan Panjang pipa. Data diolah menggunakan metode analisis Benefit Cost Ratio (BCR), Nett present value (NPV) dan Internal Rate Return (IRR). Hasil Penelitian menunjukkan Sumber air yang ada di Desa Wanagiri Kecamatan Sukasada layak untuk memenuhi kebutuhan air saat ini sampai dengan 10 tahun kedepan dari perbandingan debit tersedia dengan debit kebutuhan terdapat surplus sebesar 0,57 l/dt pada tahun awal (2020) dan surplus sebesar 0,11 l/dt pada akhir tahun proyeksi (2030). Jika mengacu pada harga air PDAM Kabupaten Buleleng sebesar Rp. 2.130 / m3 diperoleh nilai BCR lebih kecil dari 1 (0,14 < 1), nilai NPV bernilai negatif sebesar - Rp. 1.478.138.750 dan IRR < MARR (7,3% < 8,2%) sehingga sistem pompa yang direncanakan tidak layak secara finansial. Setelah dilakukan penyesuaian harga air dengan harga air sebesar Rp. 3.500 / m3 diperoleh nilai BCR lebih besar dari 1 (4,8 > 1), nilai NPV bernilai positif sebesar Rp. 6.582.216.530 dan IRR > MARR (8,8% > 8,2%) sehingga dapat disimpulkan bahwa sistem pompa yang direncanakan layak secara finansial.
The Effect of Dual Hyperparameter Optimization on Software Vulnerability Prediction Models
Authors: Bassi Deepali , Singh Hardeep 
Published: December 2022

Background: Prediction of software vulnerabilities is a major concern in the field of software security. Many researchers have worked to construct various software vulnerability prediction (SVP) models. The emerging machine learning domain aids in building effective SVP models. The employment of data balancing/resampling techniques and optimal hyperparameters can upgrade their performance. Previous research studies have shown the impact of hyperparameter optimization (HPO) on machine learning algorithms and data balancing techniques.
Aim: The current study aims to analyze the impact of dual hyperparameter optimization on metrics-based SVP models.
Method: This paper has proposed the methodology using the python framework Optuna that optimizes the hyperparameters for both machine learners and data balancing techniques. For the experimentation purpose, we have compared six combinations of five machine learners and five resampling techniques considering default parameters and optimized hyperparameters.
Results: Additionally, the Wilcoxon signed-rank test with the Bonferroni correction method was implied, and observed that dual HPO performs better than HPO on learners and HPO on data balancers. Furthermore, the paper has assessed the impact of data complexity measures and concludes that HPO does not improve the performance of those datasets that exhibit high overlap.
Conclusion: The experimental analysis unveils that dual HPO is 64% effective in enhancing the productivity of SVP models.
Relationship between Molecular Subtype, Degree of Differentiation, and Lymph Node Metastasis with Survival of Breast Cancer Patients at Dr. M. Djamil General Hospital, Padang, Indonesia
Authors: Arza Isra Analdo , Daan Khambri  , Rony Rustam  , Hera Novianti  , Husna Yetti  
Published: December 2022

Background: Breast cancer has the highest incidence of all cancers in women worldwide. A molecular subtype of breast cancer, degree of differentiation, and lymph node metastasis are prognostic and predictive factors of breast cancer. This study aims to explore the relationship between molecular subtype, degree of differentiation, and lymph node metastasis with overall survival and disease-free survival of breast cancer patients at Dr. M. Djamil General Hospital Padang.
Methods: This study was an analytic observational study with a retrospective cohort approach using secondary data from 68 subjects. The test variables in this study were the molecular subtype of breast cancer, the degree of differentiation, and lymph node metastasis which were obtained from secondary data and medical records. Another test variable is patient survival, namely overall survival (OS) and disease-free survival (DFS). Data analysis with the help of SPSS software in univariate, bivariate, and multivariate.
Results: Patients with lymph node metastases were 7.94 times more likely to experience an event (death) (HR=7.94 95% CI: 0.91–78.2). Patients with lymph node metastases were 10.2 times more likely to experience an event (recurrence) (HR=10.2 95% CI: 1.03–101.1).
Conclusion: Lymph node metastases are the factors most related to survival (overall survival and disease-free survival) of breast cancer patients at Dr. M. Djamil General Hospital, Padang, Indonesia.