bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Nano Titanium Oxide with Different Surface Treatments on Color Stability of Red-Tinted Silicone Rubber
Authors: Wang Yalin 
Published: August 2022

To improve the color stability of facial prosthesis silicone rubber, this paper studied the effect of nano titanium oxide with different surface treatments on the color stability of red pigment-colored silicone rubber. Under the simulated sunlight aging condition, this paper takes MDX4-4210 silicone rubber as the matrix, silicon aluminum-coated nano TiO2 as the shading agent, and cadmium red oil paint as the colorant, and it observes the values of silicon aluminum-coated nano-TiO2 silicone rubber film with 1 mm thickness and different concentrations (0, 0.05%, 0.10%, and 0.15%) before and after aging. The experimental results showed that in the four concentrations of silicon aluminum-coated nano-TiO2 film, the

Δ
E
,
Δ

L

∗

,

Δ

a

∗

,

Δ

b

∗

values gradually decreased with the increase of the concentration of silicon aluminum-coated nano-TiO2. The lowest was in the 0.10% group; however, it increased in the 0.15% group. There was a significant difference among the concentration groups

P
<
0.05

. The method of covering nano-TiO2 silicone rubber film with different concentrations of silicon aluminum has a certain effect on delaying the discoloration of prosthetic silicone rubber, and it provides a new idea for improving the color stability of the prosthetic silicone rubber.
Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart
Authors: Nakayama Yoshinobu , Mukai Nobuhiro , Kreitzer Geri , Patwari Parth , Yoshioka Jun 
Published: August 2022

Background:
An ancient family of arrestin-fold proteins, termed alpha-arrestins, may have conserved roles in regulating nutrient transporter trafficking and cellular metabolism as adaptor proteins. One alpha-arrestin, TXNIP (thioredoxin-interacting protein), is known to regulate myocardial glucose uptake. However, the in vivo role of the related alpha-arrestin, ARRDC4 (arrestin domain-containing protein 4), is unknown.

Methods:

We first tested whether interaction with GLUTs (glucose transporters) is a conserved function of the mammalian alpha-arrestins. To define the in vivo function of ARRDC4, we generated and characterized a novel
Arrdc4
knockout (KO) mouse model. We then analyzed the molecular interaction between arrestin domains and the basal GLUT1.

Results:

ARRDC4 binds to GLUT1, induces its endocytosis, and blocks cellular glucose uptake in cardiomyocytes. Despite the closely shared protein structure, ARRDC4 and its homologue TXNIP operate by distinct molecular pathways. Unlike TXNIP, ARRDC4 does not increase oxidative stress. Instead, ARRDC4 uniquely mediates cardiomyocyte death through its effects on glucose deprivation and endoplasmic reticulum stress. At baseline,
Arrdc4
-KO mice have mild fasting hypoglycemia.
Arrdc4
-KO hearts exhibit a robust increase in myocardial glucose uptake and glycogen storage. Accordingly, deletion of
Arrdc4
improves energy homeostasis during ischemia and protects cardiomyocytes against myocardial infarction. Furthermore, structure-function analyses of the interaction of ARRDC4 with GLUT1 using both scanning mutagenesis and deep-learning
Artificial Intelligence
identify specific residues in the C-terminal arrestin-fold domain as the interaction interface that regulates GLUT1 function, revealing a new molecular target for potential therapeutic intervention against myocardial ischemia.

Conclusions:
These results uncover a new mechanism of ischemic injury in which ARRDC4 drives glucose deprivation-induced endoplasmic reticulum stress leading to cardiomyocyte death. Our findings establish ARRDC4 as a new scaffold protein for GLUT1 that regulates cardiac metabolism in response to ischemia and provide insight into the therapeutic strategy for ischemic heart disease.
European Divergent Approaches to Protection Claims Based on the Eritrean Military/National Service Programme
Authors: Palacios-Arapiles Sara 
Published: August 2022

Abstract
Drawing on data from the United Kingdom, Sweden, Germany, and Switzerland, this article shows that during the process of interpreting the refugee definition and applying it to the context of the Military/National Service Programme (MNSP), the definition is subject to various interpretations and applications. As a result, the treatment of similarly situated Eritrean asylum applications differs from one country to another. The article illustrates that asylum courts from the selected jurisdictions sideline relevant factors that classify the MNSP as slavery by failing to engage normatively with the international law definition of slavery. The findings suggest that a defective incorporation of international legal instruments in the assessment of protection claims based on slavery contributes to conflicting interpretations and applications of the refugee definition and can unduly de-legitimise Eritrean applications for refugee status as ‘unwanted migrants’.
I. Howard Marshall
Authors: White Aaron W. 
Published: August 2022

Abstract
In 1970, I. H. Marshall published Luke: Historian and Theologian. The influence Marshall had by the publication of Luke: Historian and Theologian has been seen in the various effects the book had on redaction-criticism in the field of New Testament studies, and how Luke, the writer of Luke-Acts, has since been appreciated as both a theologian and an historian, not one or the other, as it was before Marshall’s work. In 2021 at the 73rd national meeting of the Evangelical Theological Society and after a one-year postponement following the global pandemic, the Luke-Acts steering committee celebrated the 50th year of the publication of Marshall’s book with a section specifically dedicated to aspects of the book and its legacy.
Internal Wave and Turbulence Observations with Very High-Resolution Temperature Sensors along the Cabauw Mast
Authors: van Haren Hans , Bosveld Fred C. 
Published: August 2022

Abstract
Knowledge about the characteristics of the atmospheric boundary layer is vital for the understanding of redistribution of air and suspended contents that are particularly driven by turbulent motions. Despite many modeling studies, detailed observations are still demanded of the development of turbulent exchange under stable and unstable conditions. In this paper, we present an attempt to observationally describe atmospheric internal waves and their associated turbulent eddies in detail, under varying stable conditions. Therefore, we mounted 198 high-resolution temperature (T) sensors with 1-m spacing on a 200-m-long cable. The instrumented cable was attached along the 213-m-tall meteorological mast of Cabauw, Netherlands, during late summer 2017. The mast has standard meteorological equipment at extendable booms at six levels in height. A sonic anemometer is at 60 m above ground. The T sensors have a time constant in air of τa ≈ 3 s and an apparent drift about 0.1°C month−1. Also due to radiation effects, short-term measurement instability is 0.05°C h−1 during nighttime and 0.5°C h−1 during daytime. These T-sensor characteristics hamper quantitative atmospheric turbulence research, due to a relatively narrow inertial subrange of maximum one order of magnitude. Nevertheless, height–time images from two contrasting nights show internal waves up to the buoyancy period of about 300 s, and shear and convective deformation of the stratification over the entire 197-m range of observations, supported by nocturnal marginally stable stratification. Moderate winds lead to 20-m-tall convection across weaker stratification, weak winds to episodic <10-m-tall shear instability across larger stratification.
Postoperative Complications Following Pharyngolaryngectomy With Total Esophagectomy: Comparison Between Cervical and Anterior Mediastinal Tracheostomy
Authors: Kanie Yasukazu , Okamura Akihiko , Kanamori Jun , Imamura Yu , Kamiyama Ryosuke , Seto Akira , Shimbashi Wataru , Sasaki Toru , Fukushima Hirofumi , Mitani Hiroki , Watanabe Masayuki 
Published: August 2022

Objectives: Pharyngolaryngectomy with total esophagectomy (PLTE) is associated with high morbidity and mortality rates. Cervical tracheostomy (CT) is the first choice of tracheostomy, whereas anterior mediastinal tracheostomy (AMT) is sometimes required due to tumor extension or insufficient blood supply to the tracheal tip. However, the differences in the outcomes between CT and AMT after PLTE remain unclear. Methods: We retrospectively reviewed 67 patients who underwent PLTE and compared the clinical features and postoperative complications between patients with CT and AMT. The characteristics and the outcomes were compared between the groups stratified by the causes of AMT. Results: Of the 67 patients, 42 (62.7%) patients underwent PLTE with CT (CT group), whereas 25 (37.3%) underwent PLTE with AMT (AMT group). The AMT group included more cervicothoracic esophageal cancers and had showed an advanced T stage compared to the CT group ( P < .01 and .01, respectively). The incidences of pneumonia and surgical site infection (SSI) were more frequent in the AMT group than in the CT group ( P = .03 and .01, respectively). Surgery-related mortality was only observed in the AMT group. In the AMT group, 17 (68.0%) and 8 (32.0%) patients underwent AMT because of tumor extension and insufficient supply to the tracheal tip. The latter cases underwent transthoracic esophagectomy more frequently than former cases ( P = .03). Conclusion: AMT after PLTE had more postoperative complications and mortality than CT. In cases that may need AMT, a transhiatal approach is preferable over transthoracic esophagectomy to avoid fatal complications when oncologically permissive.
Financial Capital and the Parliamentary Coup in Brazil: Division, Reunification, and Crisis of Hegemony
Authors: Valle André Flores Penha 
Published: August 2022

The political action of financial capital and its class fractions in 2015–2016 resulted in the overthrow of President Dilma Rousseff and her replacement by Michel Temer's interim government. Financial capital at the time was made up of the internal banking bourgeoisie, involving the large national commercial banks, and the associated financial bourgeoisie, involving nonbank financial institutions operating in the capital market. Examination of the relationship between financial capital and other bourgeois fractions in this context disputes the hypotheses of a bourgeois united front and of a convergence around rentism to demonstrate that the Brazilian bourgeoisie did not constitute a political front that overthrew the government as a bloc. A ação política do capital financeiro e suas frações de classe em 2015-2016 resultou na derrubada da presidente Dilma Rousseff e sua substituição pelo governo interino de Michel Temer. O capital financeiro da época era constituído pela burguesia bancária interna, envolvendo os grandes bancos comerciais nacionais bem como a burguesia financeira associada, abrangendo as instituições financeiras não bancárias que atuavam no mercado de capitais. Uma investigação sobre a relação entre capital financeiro e outras frações burguesas nesse contexto contesta as hipóteses de uma frente única burguesa e de uma convergência em torno do rentismo para demonstrar que a burguesia brasileira não constituiu uma frente política que derrubou o governo como bloco.
Magnetic resonance imaging thicknesses and apparent diffusion coefficient values of the endometrium and junction zone in women of reproductive age
Authors: Liubing Chen , Ting Song , Xi Peng , Yonglu Chen , Yi Liu , Jun Yang Yong , Liuqing Chen 
Published: August 2022

Background The endometrium and uterine junction zone often change throughout the menstrual cycle. Some pathological conditions may appear normal in uterine imaging, which will lead to missed diagnosis and misdiagnosis. Purpose To evaluate the changes in the thickness and apparent diffusion coefficient (ADC) values of the endometrium and uterine junction zone throughout the menstrual cycle in magnetic resonance imaging (MRI) of women of reproductive age. Material and Methods Data were collected from 40 healthy women of reproductive age with regular menstrual cycles from January 2017 to April 2018. They underwent four total MRI sessions during the menstrual, proliferation, and early and late secretive phases. The main MRI sequences were T2-weighted (T2W) volume isotropic turbo spin echo acquisition (VISTA) spectral attenuated inversion recovery (SPAIR) and diffusion-weighted imaging (b = 0, 600, 800, 1000 s/mm2), which were used to measure the thicknesses and ADC values of endometrium and uterine junction zone. Results First, the endometrium was thinnest during the menstrual phase and thickest in the late secretive phase. Second, the uterine junction zone was thinnest in the late secretive phase and thickest in the menstrual phase. Third, the ADC values of the endometrium were lowest in the menstrual phase and peaked in the early secretive phase. Finally, the ADC values of the uterine junction zone were lowest in the menstrual phase and peaked in the late secretive phase. Conclusion The endometrium and uterine junction zone showed cyclic changes. Radiologists should consider these changes in the thickness and ADC values when analyzing MRI images of the uterus.
CCNB1 and CCNB2 involvement in the pathogenesis of psoriasis: a bioinformatics study
Authors: Li An-hai , Chen Yong-qing , Chen Yu-qian , Song Yun , Li Ding 
Published: August 2022

Objective The cell cycle-related proteins cyclin B1 (CCNB1) and cyclin B2 (CCNB2) are potentially involved in the underlying mechanisms of psoriasis. The present study aimed to explore this possibility using bioinformatics approaches. Methods CCNB1 and CCNB2 protein levels were evaluated in 14 psoriasis patients and five healthy controls by enzyme-linked immunosorbent assays, and their mRNA levels were evaluated using data from four publicly available datasets (GSE53552, GSE41664, GSE14905, and GSE13355). Comparison of high- and low-expressing groups were performed to reveal CCNB1- and CCNB2-related differentially expressed genes, which were then assessed based on gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. Correlation analyses between CCNB1 and CCNB2 levels and immune infiltration, as well as typical targets of psoriasis, were also performed. Results Overall, 12 CCNB1 and CCNB2 common immune-related targets potentially involved in psoriasis were identified. These could regulate the cell cycle of through multiple pathways. In addition, CCNB1 and CCNB2 were found to potentially support the release of key molecular targets of psoriasis through the regulation of mast cell activation and macrophage polarization. Conclusions These findings suggest that CCNB1 and CCNB2 may represent valuable molecular biomarkers of psoriasis, contributing to its onset and progression.
Prognostic significance of TG/HDL-C and non-HDL-C/HDL-C ratios in patients with non-small cell lung cancer: a retrospective study
Authors: Kong Lingxin , Zhao Qingtao , Han Zhaohui , Xue Wenfei , Hu Zhonghui , Niu Zhancong , Duan Guochen 
Published: August 2022

Objective Lung cancer is a malignancy with high a mortality rate that threatens human health. This study is aimed to explore the correlation among the triglyceride/high-density lipoprotein ratio (TG/HDL-C), non-high-density lipoprotein/high-density lipoprotein ratio (non-HDL-C/HDL-C) and survival of patients with non-small cell lung cancer (NSCLC) undergoing video-associated thoracic surgery (VATS). Methods This retrospective study analyzed 284 patients with NSCLC who underwent VATS at Hebei General Hospital, Shijiazhuang, China. The time-dependent receiver operating characteristic curve was used to determine the optimal cutoff value and evaluate the area under the curve. Kaplan–Meier and Cox regression analyses were performed to determine the prognostic effect. Results The median overall survival (OS) was 46 months. Patients with low TG/HDL-C and low non-HDL-C/HDL-C had a longer OS. The low non-HDL-C/HDL-C group showed a longer mean survival time (59.00 vs. 52.35 months). Multivariate analysis revealed that TG/HDL-C and non-HDL-C/HDL-C were significantly correlated with OS. Conclusions TG/HDL-C and non-HDL-C/HDL-C are associated with the prognosis of patients with NSCLC who received VATS. Preoperative serum TG/HDL-C and non-HDL-C/HDL-C may be effective independent prognostic factors for predicting the outcomes of patients with NSCLC.
Influence of Maternal Body Fat on Levels of Insulin, Insulin-Like Growth Factor-1, and Obestatin
Authors: Badillo-Suárez Pilar A. , Rodríguez-Cruz Maricela , Bernabe-García Mariela , Villa-Morales Judith , Iglesias-Rodríguez Ricardo , Canizales-Quinteros Samuel , Carmona-Sierra Fairt V. 
Published: August 2022

Background: Insulin, insulin-like Growth Factor-1 (IGF-1), and obestatin in human milk originate from the circulation. There is also limited knowledge about the influence of body fat on the levels of these hormones in human milk. Research Aim: To determine (1) the influence of body fat on levels of insulin, IGF-1, and obestatin in human milk and serum/plasma during the postpartum period; (2) the changes in the levels of these hormones in human milk and serum/plasma postpartum; and (3) the presence of IGF-1 mRNA in human milk. Methods: In this prospective, longitudinal, observational cohort study, levels of insulin, IGF-1, and obestatin were measured up to 30 days postpartum in milk and serum/plasma of 58 participants with adequate (≤ 32%) or excess (> 32%) total body fat determined by electrical bioimpedance. Student’s t test and repeated-measures analysis of variance were used to evaluate the differences between groups. Pearson’s test was used to analyze the associations. Results: The milk from participants with excess body fat had higher insulin and IGF-1 levels and lower obestatin levels than that of participants with adequate body fat at 3–7, 14–15, and 30 days postpartum (adjusted p < .001). The levels of insulin, IGF-1, and obestatin were significantly higher in human milk than in serum/plasma ( p < .05) and correlated with maternal body fat ( p < .001). Conclusions: Maternal body fat was associated with elevated insulin and IGF-1 levels and decreased obestatin levels in human milk up to 30 days postpartum.
Use of a Novel Standardized Administration Protocol Reduces Agitation Pro Re Nata (PRN) Medication Requirements: The Birmingham Agitation Management (BAM) Initiative
Authors: Burk Bradley G. , Penherski Peter , Snider Kendall , Lewellyn Lesli , Mattox Lisa , Polancich Shea , Fargason Rachel , Waggoner Barry , Caine Elizabeth , Hand Wren , Eagleson Reid M. , Birur Badari 
Published: August 2022

Background: Agitation management is a principal challenge on inpatient psychiatric units. Overreliance on common prescribing strategies of pro re nata (PRN) medication administration is problematic, given the tendencies to have overlapping or unclear indications. Objective: Piloted project to determine whether a standardized protocol for agitation intervention may reduce PRN medication administration. Methods: The Birmingham Agitation Management (BAM) interdisciplinary team uniquely connected the Brøset Violence Checklist (BVC) for assessment of agitation severity to a standardized PRN medication order set. Nurses on the piloted unit were trained on how to score the BVC and administer medications. Patients were assessed by the BVC every 4 hours and, based on their score, would receive no medication, low-dose benzodiazepine, high-dose benzodiazepine, or high-dose benzodiazepine plus antipsychotic. The primary end point compared the number of PRNs administered after novel protocol implementation with a retrospective cohort. Secondary measures included analysis of medication-related effects, seclusion, and physical restraint rates. Results: 377 patients were included in the final analyses (184 pre-BAM, 193 BAM intervention group). No significant differences were seen in patient characteristics between groups. The total number of PRNs administered decreased by 42.5%, with both the mean and median number of administrations decreasing significantly (95% confidence interval [CI] = [1.68-5.75]; P < 0.001). A trend was noted between the number of PRNs administered and seclusion rates, but did not reach statistical significance (95% CI = [–7.28 to 60.31]; P = 0.124). Conclusions: In seemingly the first initiative of its kind, we found that a standardized agitation management protocol can help decrease the total number of PRN administrations for agitation without worsening of restraint rates and may possibly reduce the risk of adverse effects. These results require validation in specific, larger populations.
Youth Assets and Initiation of Sexual Intercourse by Family Structure: A Longitudinal Cohort Study
Authors: Sanchez Louisiana M. , Oman Roy F. , Yang Yueran , Lensch Taylor , Clements-Nolle Kristen 
Published: August 2022

Background The purpose of this study was to assess the protective influence of individual, family, and community assets from the initiation of sexual intercourse (ISI) for adolescents living in one-parent households compared with adolescents living in two-parent households. Methods Five waves of data were collected annually over a 4-year period ( N = 591, 52.5% female, mean age = 14.0 years) from a racially/ethnically diverse sample of adolescents. Extended Cox models were used to assess the relationship between assets and time of ISI while controlling for demographic variables. Potential interactions between adolescent’s household structure and assets were examined. Results Five of 17 assets were prospectively and significantly associated with a reduced risk of ISI among adolescents living in one-parent households compared with 11 of 17 assets for adolescents living in two-parent households. Adolescents living in one-parent households who possessed any one of five assets (e.g., general aspirations for the future, relationship with mother, positive peer role models) had between a 27% and 57% lower risk of ISI, whereas adolescents living in two-parent households who possessed any of one of 11 assets (e.g., responsible choices, family communication, community involvement) had between a 20% and 42% lower risk of ISI. Conclusion The results suggest that strengthening specific youth assets across multiple dimensions of behavioral influence may decrease the risk of ISI for adolescents living in both one-parent and two-parent households. Public health efforts focused on developing programs to promote asset building tailored to adolescent’s family structure are warranted.