bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of a structured weight-loss treatment on physical fitness in patients with psoriatic arthritis and obesity compared to matched controls: a prospective interventional study
Authors: Bilberg Annelie , Larsson Ingrid , Björkman Sofia , Eliasson Björn , Klingberg Eva 
Published: June 2022

Abstract
Objectives
To evaluate the effects of weight loss treatment on physical fitness in patients with psoriatic arthritis (PsA) and obesity compared to matched controls.

Methods
In total, 46 patients with PsA (CASPAR) and BMI ≥ 33 kg/m2 and 52 obese persons were included in this 12-month prospective open intervention study with a very low energy diet (640 kcal/day), followed by structured reintroduction of an energy-restricted diet and brief support for physical activity. The primary outcome was muscle strength assessed with hand-grip strength (Grippit) and leg muscle strength (timed stand test). Secondary outcomes were cardiorespiratory fitness, body composition, and physical functioning (SF-36PCS). Outcomes were assessed at baseline, 6 (M6), and 12 months (M12). Nonparametric statistics were used.

Results
Median weight reduction at M6 was 18.9 kg in patients and 23.0 kg in controls, (p = 0.546). At M12, patients’ median weight loss from baseline was 16.1 kg, corresponding with significant loss of total fat mass (− 30.1%), and lean mass (total − 7.0%, arm − 13.7%, and leg − 6.0%). Leg muscle strength improved in patients and controls at M6 (p < 0.001) and remained improved at M12 (p < 0.01), while hand-grip strength was unchanged in both groups. Cardiorespiratory fitness increased in controls at M6 (p = 0.018) and M12 (p = 0.028) but not in patients. Physical functioning improved in both groups at M6 (p < 0.001) and remained improved at M12 (p = 0.008) and (p < 0.01), respectively.

Conclusion
The intervention resulted in positive effects on body weight and total body fat. Despite reduced lean body mass, the muscle strength did not deteriorate in patients with PsA and controls.

Trial registration
ClinicalTrials.gov identifier: NCT02917434, registered on September 21, 2016-retrospectively registered.

Key Points• Patients with PsA and obesity can benefit from weight loss treatment without the risk of deterioration in muscle strength and cardiorespiratory fitness.• Muscle strength and cardiorespiratory fitness were below suggested normative values for the majority of the patients at all time points, implying that more structured exercise strategies might be warranted to counteract physical fitness deficiencies in patients with PsA undergoing weight loss treatment.
Simplified Histologic Mucosal Healing Scheme (SHMHS) for inflammatory bowel disease: a nationwide multicenter study of performance and applicability
Authors: Caputo A. , Parente P. , Cadei M. , Fassan M. , Rispo A. , Leoncini G. , Bassotti G. , Del Sordo R. , Metelli C. , Daperno M. , Armuzzi A. , Villanacci V. ,   The SHMHS Study Group
Published: June 2022

Abstract
Background
Assessment of mucosal healing is important for the management of patients with inflammatory bowel disease (IBD), but endoscopy can miss microscopic disease areas that may relapse. Histological assessment is informative, but no single scoring system is widely adopted. We previously proposed an eight-item histological scheme for the easy, fast reporting of disease activity in the intestine. The aim of the present study was to evaluate the performance of our Simplified Histologic Mucosal Healing Scheme (SHMHS).

Methods
Between April and May 2021 pathologists and gastroenterologists in Italy were invited to contribute to this multicenter study by providing data on single endoscopic–histological examinations for their IBD patients undergoing treatment. Disease activity was expressed using SHMHS (maximum score, 8) and either Simple Endoscopic Score for Crohn’s Disease (categorized into grades 0–3) or Mayo Endoscopic Subscore (range 0–3).

Results
Thirty hospitals provided data on 597 patients (291 Crohn’s disease; 306 ulcerative colitis). The mean SHMHS score was 2.96 (SD = 2.42) and 66.8% of cases had active disease (score ≥ 2). The mean endoscopic score was 1.23 (SD = 1.05), with 67.8% having active disease (score ≥ 1). Histologic and endoscopic scores correlated (Spearman’s ρ = 0.76), and scores for individual SHMHS items associated directly with endoscopic scores (chi-square p < 0.001, all comparisons). Between IBD types, scores for SHMHS items reflected differences in presentation, with cryptitis more common and erosions/ulcerations less common in Crohn’s disease, and the distal colon more affected in ulcerative colitis.

Conclusions
SHMHS captures the main histological features of IBD. Routine adoption may simplify pathologist workload while ensuring accurate reporting for clinical decision making.
A Case for Playful Engagement: Synchrony and Interaction Quality During Mirroring in ASD. Conceptual Framework and Case Study
Authors: Manders Elizabeth , Koch Sabine C. , Fuchs Thomas 
Published: June 2022

AbstractThe social challenges in autism spectrum disorders (ASD) can present as qualitative differences in interactions that make individuals on the autism spectrum appear less engaged with others. Limited interactional synchrony and other nonverbal movement patterns may contribute to these qualitative differences. This article uses the case of Hans, an adult on the autism spectrum, to describe patterns of synchrony and interaction quality during mirroring activities in dance/movement therapy. Raters scored videos of Hans and his partners on affective engagement, flow of the interaction, and interpersonal synchrony. They also qualitatively described his movements and interactions. Hans consistently participated in mirroring, but showed different patterns of attention and engagement when leading, following, interacting, or dancing in an open-ended dance. Hans was able to move in synchrony with partners, showed positive affect, and increased his movement repertoire by returning to others’ movements in later sessions. He was the most engaged when following a playful movement theme with a dance/movement therapy student partner. His affective engagement increased, but only in the less structured open-ended dance and only across the five sessions with this same dance/movement therapy student partner, and not when the sessions with his other partners, including others on the autism spectrum, were included. This points to a potential need to have dance/movement therapists model developing a movement relationship using flexible and playful contexts to emotionally engage the individual and reflect the complexity of everyday social situations. We present clinical recommendations and suggestions for future studies.
Fine-scale fern ecological responses inform on riparian forest habitat conservation status
Authors: Bonari Gianmaria , Fattorini Niccolò , Fruchter Sophie Rose , Angiolini Claudia , Baragatti Elisa , Landi Marco 
Published: June 2022

AbstractThe recognition of the ecological quality of ecosystems and habitats therein is increasingly important in the Anthropocene. However, there are still scarcely explored ways of how and what to assess to obtain a sound ecological status of habitats. Ferns are an understudied plant group, especially given their usefulness as ecological indicators. Disentangling biotic and abiotic factors that drive fine-scale fern distribution could provide insight into the quality of their habitats. We investigated the environmental factors affecting the distribution of different largely distributed fern species in Europe. We studied their presence and abundance at different life stages in a forest habitat of European priority conservation concern. Our aim was to understand whether fern species can be used as an ecological indicator group in riparian alderwood habitat. We sampled 120 plots of 50 m2 in randomly selected transects along streams of a riparian forest habitat characterized by the presence of many fern species in the understory, controlling for the effects of geology and elevation. Within each plot, fern species were recorded, including vegetative and generative stages of each ramet (rosette of fronds). We modelled fern occurrence and abundance for the different fern life stages, and diversity indices of the fern community in relation to environmental predictors. We found that population- and community-level responses of ferns mainly depended on soil granulometry and, to a lesser extent, moss cover and stream orientation. We also found that the generative life stage compared to the vegetative adult stage benefits from different ecological characteristics for certain fern species. Alterations of the natural hydrology might lead to a general deterioration in habitat quality for ferns. We suggest that some fern species acting as early-warning species, and potentially their life stages, can be used as an ecological quality indicator for riparian forest habitats. This study deepened the understanding of the fine-scale ecology of an array of European ferns in riparian forests and provides valuable information to assist in the conservation of fern species and their populations.
A meiotic driver alters sperm form and function in house mice: a possible example of spite
Authors: Winkler Lennart , Lindholm Anna K. 
Published: June 2022

AbstractThe ability to subvert independent assortment of chromosomes is found in many meiotic drivers, such as thethaplotype in house miceMus musculus, in which thet-bearing chromosomal homolog is preferentially transmitted to offspring. This is explained by a poison-antidote system, in which developing + andtsperm in testes of + /tmales are exposed to ‘poison’ coded bytloci, from whichtsperm are protected, allowingtsperm an overwhelming fertilisation advantage in monogamous matings. This system is thought to result in poorly and normally motile sperm subpopulations within + /tsperm, leavingtsperm unharmed. Conversely, we found that the fastest quartile of sperm from + /tmales swam more slowly, both forwards and along their travel path, and had reduced straightness and linearity, compared to the fastest quartile of + / + sperm. Moreover, sperm from + /tmales had shorter tails and narrower heads than + / + sperm, and these morphological differences covaried with motility differences. Finally, + /ttraits did not show evidence of bimodal distributions. We conclude that thethaplotype drive results in lasting damage to the motility of both + andtdeveloping sperm, although previous studies indicate that + must be more harmed thantsperm. This damage to all sperm may explain the low success of + /tmales in sperm competition with + / + males, seen in earlier studies. We propose that the harm thetcauses to itself could be termed ‘spiteful’, which may also be common to other gamete-harming meiotic drive systems.
Simulating local fields in carbon nanotube-reinforced composites for infinite strip with voids
Authors: Nasser Mohamed M. S. , Kalmoun El Mostafa , Mityushev Vladimir , Rylko Natalia 
Published: June 2022

AbstractA numerical simulation of the thermal properties is conducted for an isotropic and homogeneous infinite strip composite reinforced by carbon nanotubes (CNTs) and containing voids. The CNTs can be uniformly or randomly distributed but are non-overlapping. We model the CNTs as thin perfectly conducting elliptic inclusions and assume the voids to be of circular shape and act as barriers to heat flow. We also impose isothermal conditions on the external boundaries by assuming the lower infinite wall to be a heater under a given temperature, and the upper wall to be a cooler that can be held at a lower fixed temperature. The mathematical model, which takes the form of a mixed Dirichlet–Neumann problem, is solved by applying the boundary integral equation with the generalized Neumann kernel. We illustrate the performance of the proposed method through several numerical examples including the case of the presence of a large number of CNTs and voids.
Molecular identification and habitat requirements of the hybrid Ranunculus circinatus × R. fluitans and its parental taxa R. circinatus and R. fluitans in running waters
Authors: Gebler Daniel , Zalewska-Gałosz Joanna , Jopek Magdalena , Szoszkiewicz Krzysztof 
Published: June 2022

AbstractRanunculus species grouped in the section Batrachium (water crowfoots) indicate the most valuable fluvial habitat in Europe under the EU Habitats Directive, and recognition of their environmental preferences plays a crucial role in efficient conservation. Moreover, water crowfoots are used in various monitoring systems throughout Europe. The aim of this study was to identify the distribution patterns of two common water crowfoot species (Ranunculus fluitans, R. circinatus) and their hybrid (R. circinatus × R. fluitans) in relation to environmental variables in rivers. Various chemical and hydromorphological parameters were estimated for 54 river sites where 58 different Batrachium populations were recorded. Our study revealed the most distinct positive reaction of R. fluitans to rhithral conditions characterized by rapid currents and coarse substrate. R. circinatus × R. fluitans preferred larger channels, although this taxon also flourished in rhithral rivers. The preferences of R. circinatus were not so evident confirming its occurrence under a wide range of habitat conditions. The ecological reaction of the hybrid was compared with its parental species, revealing their ecological specificity, which is useful in designing appropriate conservation programmes.
A hybrid genetic algorithm for parallel machine scheduling with setup times
Authors: Adan J. 
Published: June 2022

AbstractThis paper addresses the unrelated parallel machine scheduling problem with sequence and machine dependent setup times and machine eligibility constraints. The objective is to minimize the maximum completion time (makespan). Instances of more than 500 jobs and 50 machines are not uncommon in industry. Such large instances become increasingly challenging to provide high-quality solutions within limited amount of computational time, but so far, have not been adequately addressed in recent literature. A hybrid genetic algorithm is developed, which is lean in the sense that is equipped with a minimal number of parameters and operators, and which is enhanced with an effective local search operator, specifically targeted to solve large instances. For evaluation purposes a new set of larger problems is generated, consisting of up to 800 jobs and 60 machines. An extensive comparative study shows that the proposed method performs significantly better compared to other state-of-the-art algorithms, especially for the new larger instances. Also, it is demonstrated that calibration is crucial and in practice it should be targeted at a narrower set of representative instances.
Cultural Protection from Polysubstance Use Among Native American Adolescents and Young Adults
Authors: Brockie Teresa N. , Campbell Jacquelyn C. , Dana-Sacco Gail , Farley Jason , Belcher Harolyn M. E. , Kub Joan , Nelson Katie E. , Ivanich Jerreed D. , Yang Li , Wallen Gwenyth , Wetsit Lawrence , Wilcox Holly C. 
Published: June 2022

AbstractReservation-based Native American youth are at disproportionate risk for high-risk substance use. The culture-as-treatment hypothesis suggests aspects of tribal culture can support prevention and healing in this context; however, the protective role of communal mastery and tribal identity have yet to be fully explored. The objectives of this study were to investigate (1) the relationship between cultural factors and high-risk substance use, which includes polysubstance use, early initiation of alcohol and illicit drugs, and binge drinking, and (2) substance use frequency and prevalence of various substances via cross-sectional design. Multiple logistic regression modeling was used to analyze data from 288 tribal members (15–24 years of age) residing on/near the Fort Peck Reservation in the Northern Plains. When controlling for childhood trauma and school attendance, having at least a high school education (OR = 0.434, p = 0.028), increased communal mastery (OR = 0.931, p = 0.007), and higher levels of tribal identity (OR = 0.579, p = 0.009) were significantly associated with lower odds of polysubstance use. Overall prevalence of polysubstance use was 50%, and binge drinking had the highest single substance prevalence (66%). Prevalence of early initiation of substances (≤ 14 years) was inhalants (70%), alcohol (61%), marijuana (74%), methamphetamine (23%), and prescription drug misuse (23%). Hydrocodone, an opioid, was the most frequently misused prescription drug. Findings indicate programs focused on promoting education engagement, communal mastery, and tribal identity may mitigate substance use for Native American adolescents living in high-risk, reservation-based settings.
Special Considerations for Women of Reproductive Age on Anticoagulation
Authors: Azenkot Tali , Schwarz Eleanor Bimla 
Published: June 2022

AbstractAnticoagulation poses unique challenges for women of reproductive age. Clinicians prescribing anticoagulants must counsel patients on issues ranging from menstruation and the possibility of developing a hemorrhagic ovarian cyst to teratogenic risks and safety with breastfeeding. Abnormal uterine bleeding affects up to 70% of young women who are treated with anticoagulation. As such, thoughtful clinical guidance is required to avoid having young women who are troubled by their menses, dose reduce, or prematurely discontinue their anticoagulation, leaving them at increased risk of recurrent thrombosis. Informed by a review of the medical literature, we present current recommendations for assisting patients requiring anticoagulation with menstrual management, prevention of hemorrhagic ovarian cysts, and avoiding unintended pregnancy. The subdermal implant may be considered a first-line option for those requiring anticoagulation, given its superior contraceptive effectiveness and ability to reliably reduce risk of hemorrhagic ovarian cysts. All progestin-only formulations—such as the subdermal implant, intrauterine device, injection, or pills—are generally preferred over combined hormonal pills, patch, or ring. Tranexamic acid, and in rare cases endometrial ablation, may also be useful in managing menorrhagia and dysmenorrhea. During pregnancy, enoxaparin remains the preferred anticoagulant and warfarin is contraindicated. Breastfeeding women may use warfarin, but direct oral anticoagulants are not recommended given their limited safety data. This practical guide for clinicians is designed to inform discussions of risks and benefits of anticoagulation therapy for women of reproductive age.
The Effect of Standardized Hospitalist Information Cards on the Patient Experience: a Quasi-Experimental Prospective Cohort Study
Authors: Abid Muhammad Hasan , Lucier David J. , Hidrue Michael K. , Geisler Benjamin P. 
Published: June 2022

Abstract
Background
Communication with clinicians is an important component of a hospitalized patient’s experience.

Objective
To test the impact of standardized hospitalist information cards on the patient experience.

Design
Quasi-experimental study in a U.S. tertiary-care center.

Participants
All-comer medicine inpatients.

Interventions
Standardized hospitalist information cards containing name and information on a hospitalist’s role and availability vs. usual care.

Main Measures
Patients’ rating of the overall communication as excellent (“top-box” score); qualitative feedback summarized via inductive coding.

Key Results
Five hundred sixty-six surveys from 418 patients were collected for analysis. In a multivariate regression model, standardized hospitalist information cards significantly improved the odds of a “top-box” score on overall communication (odds ratio: 2.32; 95% confidence intervals: 1.07–5.06). Other statistically significant covariates were patient age (0.98, 0.97–0.99), hospitalist role (physician vs. advanced practice provider, 0.56; 0.38–0.81), and hospitalist-patient gender combination (female-female vs. male-male, 2.14; 1.35–3.40). Eighty-seven percent of patients found the standardized hospitalist information cards useful, the perceived most useful information being how to contact the hospitalist and knowing their schedule.

Conclusions
Hospitalized patients’ experience of their communication with hospitalists may be improved by using standardized hospitalist information cards. Younger patients cared for by a team with an advanced practice provider, as well as female patients paired with female providers, were more likely to be satisfied with the overall communication. Assessing the impact of information cards should be studied in other settings to confirm generalizability.
Development of a Long-Term Operational Optimization Model for a Building Energy System Supplied by a Geothermal Field
Authors: Kümpel Alexander , Stoffel Phillip , Müller Dirk 
Published: June 2022

AbstractIn order to reduce energy consumption and CO2 emissions in the building sector, more and more renewable energy sources are integrated into energy systems. Especially geothermal fields combined with heat pumps are able to supply buildings with heat and cold at low carbon emissions. However, using geothermal fields as heat and cold source influences the ground temperature. Consequently, the ground temperature can change dramatically over a building’s lifetime, leading to less efficient operation of the energy system. Therefore, a sustainable operation is required to ensure the long-term efficiency of geothermal fields. In this paper, we develop an optimization model to derive operating strategies for an efficient long-term operation of a building energy system coupled to a geothermal field. The investigated energy system is the main building of the E.ON Energy Research Center in Aachen, Germany, which includes a heat pump, two boilers, a combined heat, and power unit, a glycol cooler, and a geothermal field with 41 probes. For each component, we develop energy-based sub-models, which are connected to form the overall system. The geothermal field is modeled by using a g-functions approach as well as a simplified resistance-capacitance approach. To achieve short computing times and realize an optimization horizon of several years, the optimization problem is formulated as mixed-integer linear programming (MILP). The developed model is optimized regarding two different objectives: the minimization of energy costs and the minimization of long-term temperature changes in the ground. Conclusions for an efficient and sustainable operation of the field, especially for the cooling supply, can be derived from the optimization results. It is shown that a state of equilibrium should be aimed to achieve an energy-efficient operation, in which the temperature of the field is close to the initial ground temperature.