bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cut from the same cloth?
Authors: Al-Saadi N , Al-Saadi A , Lewis SE , Parvin A , Busuttil A , Bowrey DJ 
Published: September 2022

We look at the experiences of hijabi women in UK operating theatres. Introduction Patients from minority backgrounds in the UK frequently have worse experiences of care than their White counterparts. A more ethnically diverse workforce could offer a solution. Despite this, medical professionals from minority backgrounds (specifically Muslim women wearing a headscarf) are less likely to pursue a career in surgery. This study evaluated the experience of medical professionals who wear the hijab (Islamic headdress) in UK operating theatres. Methods A survey was distributed nationally in 2019 and again in 2021 to hijabi Muslim medical professionals in order to gain an understanding of their overall experience in operating theatres. Ninety responses were received from the distribution of the questionnaire over both time periods (35 in 2019 and 55 in 2021). Results Three quarters (77% in 2019 and 76% in 2021) of participants reported feeling anxious about wearing a hijab in the operating theatre. Approximately half (54% in 2019 and 46% in 2021) had been asked to remove their hijab before entering theatre in the past. Overall, the majority (87%) stated that they would be more inclined to attend theatre if hijab friendly scrub caps were available and all respondents felt that more should be done to facilitate women wearing a hijab in theatre. Conclusions These findings highlight the need for improvement to ensure hijabi women feel comfortable in the operating theatre. Simple steps, including availability of sterile hijabs and implementation of hijab specific dress policies, can help create a more ethnically diverse healthcare workforce, support individuals’ talents and improve overall patient experience.
Virtual reality technology in linked orthopaedic training in Ethiopia
Authors: Lyons M , Aquilina A , Berwin J , Degarege D , Vipulendran K , Thomas S 
Published: September 2022

Introduction We describe the feasibility of delivering a live orthopaedic surgical teaching session with virtual reality (VR) technology simultaneously for trainee surgeons in Ethiopia and the UK. Methods Forty-three delegates from the Severn Deanery in the UK (n=30) and Bahir Dar in Ethiopia (n=13) attended a live training session in February 2021. During the session, participants watched a surgical operation (recorded earlier that week with a 360° VR camera) alongside live commentary. A qualitative questionnaire was distributed to gauge feasibility, connectivity and educational value of the session as well as its VR component. Results The majority of delegates from both the UK and Ethiopia felt that the use of VR technology to aid surgical training is feasible, that it is useful for learning surgical approaches, that it aids surgical performance and that it is superior to conventional resources. Bahir Dar residents strongly agreed that VR simulation videos would allow trainees to supplement reduced learning opportunities as a result of the COVID-19 pandemic and help to counteract their reduced operating experience. For Bahir Dar trainees, a lack of a stable internet connection for large VR files was the predominant issue. Conclusions This study demonstrates that there are infrastructure challenges in low and middle income countries (LMICs) in terms of the reliable delivery of VR teaching in orthopaedics at the current time. Despite this, our findings better inform the potential role of VR technology in surgical education, and shed light on the possibility for it to feed into and enrich surgical training in both LMICs and high income countries.
L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling
Authors: Akhigbe Roland Eghoghosoa , Afolabi Oladele A. , Ajayi Ayodeji F. 
Published: September 2022

Background
Although codeine has been reported to enhance sexual activity by improving penile reflexes, it has been shown to impair fertility indices. Also, codeine impairs ovarian steroidogenesis and folliculogenesis. Nonetheless, whether or not codeine exerts an epigenetic effect remains unclear. On the other hand, arginine has been speculated to enhance penile reflexes by upregulating NO/cGMP Signaling.

Aim
The study evaluated the effect of maternal codeine exposure and prepubertal codeine and arginine treatments on F1 male sexual function and fertility indices, as well as the outcome of F2 progenies. In addition, the epigenetic programming mechanism was also explored.

Methods
Forty three-week-old female rats were randomized into two groups (n = 20 rats/group); the control that received 0.5 ml of distilled water and the codeine-treated that received 5 mg/kg of codeine via gavage for eight weeks. Afterward, the female rats were paired for mating with sexually mature male rats. Rats were maintained on their pre-pregnancy treatments throughout pregnancy and lactation. FI progenies from each cohort (control and codeine-treated cohorts) were weaned at three weeks and randomized into four groups; the control, codeine-treated, L-arginine-treated (300mg/kg), and codeine + L-arginine-treated (n = 10 rats/group). Administration commenced a week post-weaning and lasted for eight weeks via gavage.

Key findings
Maternal codeine exposure did not alter body weight, but significantly reduced anogenital distance and anogenital index of F1 male offspring. Also, maternal codeine delayed preputial membrane separation, impaired male sexual competence, and penile reflexes of F1 male offsprings. These were associated with reduced dopamine, gonadotropins, and testosterone levels as well as suppressed expression of androgen receptor mRNA. In addition, maternal codeine downregulated NO/cGMP signaling, impaired fertility indices, and reduced the litter size, weight, and survival of F2 progenies. These alterations were observed to be aggravated by prepubertal codeine exposure but improved by prepubertal arginine treatment.

Significance
In conclusion, codeine programmed sexual dysfunction by suppressing the levels of dopamine and testosterone, as well as repressing the expression of androgen receptor mRNA. In addition, codeine-induced epigenetic reprogramming was expressed in the F2 offsprings as reduced litter size and weight, and survival rate. Notably, these observations were worsened by prepubertal codeine exposure, but dampened by prepubertal arginine treatment.
Minimum inhibitory concentrations of rifampin and isoniazid among multidrug and isoniazid resistant Mycobacterium tuberculosis in Ethiopia
Authors: Getahun Muluwork , Blumberg Henry M. , Ameni Gobena , Beyene Dereje , Kempker Russell R. 
Published: September 2022

Introduction
Traditionally, single critical concentrations of drugs are utilized for Mycobacterium tuberculosis (Mtb) drug susceptibility testing (DST); however, the level of drug resistance can impact treatment choices and outcomes. Mutations at the katG gene are the major genetic mutations in multidrug resistant (MDR) Mtb and usually associated with high level resistance. We assessed the minimum inhibitory concentrations (MICs) of MDR or rifampin resistant (RR) and isoniazid (INH) resistant Mtb isolates to determine the quantification of drug resistance among key anti-tuberculosis drugs.

Methods
The study was conducted on stored Mtb isolates collected as part of a national drug resistance survey in Ethiopia. MIC values were determined using Sensititre™ MYCOTB plates. A line probe assay (MTBDRplus) was also performed to identify genetic determinants of resistance for all isolates.

Results
MIC testing was performed on 74 Mtb isolates including 46 MDR, 2 RR and 26 INH phenotypically resistant isolates as determined by the Löwenstein Jensen (LJ) method. Four (15%) INH resistant Mtb isolates were detected as borderline rifampin resistance (MIC = 1 μg/ml) using MYCOTB MIC plates and no rifampin resistance mutations were detected by LPA. Among the 48 MDR/RR TB cases, 9 (19%) were rifabutin susceptible (MIC was between ≤0.25 and 0.5μg/ml). Additionally, the MIC for isoniazid was between 2–4 μg/ml (moderate resistance) for 58% of MDR TB isolates and 95.6% (n = 25) of the isolates had mutations at the katG gene.

Conclusion
Our findings suggest a role for rifabutin treatment in a subset of RR TB patients, thus potentially preserving an important drug class. The high proportion of moderate level INH resistant among MDR Mtb isolates indicates the potential benefit of high dose isoniazid treatment in a high proportion of katG gene harboring MDR Mtb isolates.
Midwives’ personal and professional attitudes towards women’s delivery choices, interventions and neonatal care
Authors: Duffy Ailbhe , Maculey Chloe , Lindow Stephen W. , O’Connell Michael P. 
Published: September 2022

Abstract

Objectives
Caesarean section (CS) rates in middle- and high-income countries are rising partly due to maternal request. This study aimed to explore the personal and professional attitudes of midwives and nurses towards women’s delivery choices, interventions and neonatal care.

Methods
Midwifery and nursing staff at the Coombe hospital were asked to complete a questionnaire concerning decisions for elective CS and neonatal care. The midwives’ responses were divided into multiparous and nulliparous according to their own parity.

Results
Multiparae and nulliparae did not differ on their personal preferences for their own baby. Only 3% wanted an elective CS in a normal, healthy pregnancy but this increased to 80.2% when there was a breech presentation and 42% if the estimated fetal weight was >4.5 kg. These numbers and trends were very close to the midwives’ professional recommendations under the same circumstances. The lower threshold for full resuscitation and ICU care was at 23 and 24 weeks gestation for both personal and professional recommendations. In the case of severely premature babies or babies with a poor prognosis, 54% stated that the approach to neonatal care was correct.

Conclusions
Overall, midwives’ professional views reflected what they would want for themselves and their babies. Only 3% recommended an elective CS in a normal, healthy pregnancy making it unlikely that midwives’ attitudes are driving the rise in CS rates in Ireland.
Minimal period problem for second-order Hamiltonian systems with asymptotically linear nonlinearities
Authors: Kuang Juhong , Chen Weiyi 
Published: September 2022

Abstract
By applying the combination of discrete variational method and approximation, developed in a previous study [J. Kuang, W. Chen, and Z. Guo, Periodic solutions with prescribed minimal period for second-order even Hamiltonian systems, Commun. Pure Appl. Anal. 21 (2022), no. 1, 47–59], we overcome some difficulties in the absence of Ambrosetti-Rabinowitz condition and obtain new sufficient conditions for the existence of periodic solutions with prescribed minimal period for second-order Hamiltonian systems with asymptotically linear nonlinearities.
Conflict or Cooperation: A Survival Analysis of the Relationship between Regional Trade Agreements and Military Conflict
Authors: Cyrus Teresa L. 
Published: September 2022

Abstract
This paper examines the timing behind the decision of countries to enter into regional trade agreements or interstate military conflicts, considering these two potential actions as substitute strategies. Using bilateral data from 1950 to 2014, I employ survival analysis to examine the factors that determine the likelihood of two countries entering into a regional trade agreement or a military conflict at any point in time. Historical or recent wars are posited to raise the gains from trade and therefore increase the likelihood that two countries choose to join the same trade agreement. On the other side, the existence of a strong trade relationship may raise the opportunity cost of entering into a conflict; bilateral trade flows and common membership in a regional trade agreement are posited to impact the likelihood of conflict. Other explanatory variables that affect the likelihood of either a common trade agreement or a military conflict include economic size, measured as the product of and the difference in the two countries’ GDPs; level of development, measured as the product of and the difference in the two countries’ per-capita GDPs; geography, measured by distance, contiguity, landlocked status, and island status; institutional linkages, represented by a common language, a colonial relationship, or a common legal origin; and political variables, including WTO membership, democracy, military alliances, and being a major oil producer. Results show that economic, geographic, institutional, and political variables all influence the probability that two countries enter into a conflict or join the same regional trade agreement.
Manager Delegation, Owner Coordination and Firms’ Investment in Automation
Authors: Stadler Manfred , Unsorg Maximiliane 
Published: September 2022

Abstract
This paper studies the combined effects of mixed ownership structures and manager delegation on firms’ investment in automation processes in a multi-stage triopoly game. We show that, in accordance with empirical evidence, firms owned by common shareholders invest less in automation and realize lower profits compared to a firm owned by independent shareholders. Direct collusion of owners in terms of coordinated investment increases the profits, the one of the independent firm even more than the profits of the commonly owned firms. Delegation of operational decisions to managers results in higher investment and lower profits. In markets with favorable technological opportunities for automation, common ownership combined with manager delegation leads to the highest social welfare.
Der Handlungskomplex Entscheiden am Beispiel der „Unterstützten Entscheidungs-findung“ in der rechtlichen Betreuung
Authors: Pick Ina 
Published: September 2022

AbstractThis paper discusses communicative decision making as an ‚action complex‘. To this end it combines empirical results on communicative decision-making processes from different fields (law, medicine, economics, politics) and compiles the constitutive action components therein. The results obtained through this are then further differentiated by analyses of “Supported Decision Making” in the GermanBetreuungsrecht(adult guardianship). The analyses led to the conclusion that the action complex can be described as a selection process, which is composed of different stages. Each stage can be reconstructed as a decision-making process in its own right (including a decision each). Thus, decision making systematically consists of several decision-making processes. The analyses show how participants negotiate their communicative movements through the action complex and how decisions emerge in the process.
Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology
Authors: Guo Sun-Wei 
Published: September 2022

In brief
Traditionally viewed as enigmatic and elusive, adenomyosis is a fairly common gynecological disease but is under-recognized and under-researched. This review summarizes the latest development on the pathogenesis and pathophysiology of adenomyosis, which have important implications for imaging diagnosis of the disease and for the development of non-hormonal therapeutics.

Abstract
Traditionally considered as an enigmatic disease, adenomyosis is a uterine disease that affects many women of reproductive age and is a contributing factor for pelvic pain, heavy menstrual bleeding (HMB), and subfertility. In this review, the new development in the pathogenesis and pathophysiology of adenomyosis has been summarized, along with their clinical implications. After reviewing the progress in our understanding of the pathogenesis and describing the prevailing theories, in conjunction with their deficiencies, a new hypothesis, called endometrial–myometrial interface disruption (EMID), which is backed by extensive epidemiologic data and demonstrated by a mouse model, is reviewed, along with recent data implicating the role of Schwann cells in the EMI area in the genesis of adenomyosis. Additionally, the natural history of adenomyotic lesions is elaborated and underscores that, in essence, adenomyotic lesions are fundamentally wounds undergoing repeated tissue injury and repair (ReTIAR), which progress to fibrosis through epithelial–mesenchymal transition, fibroblast-to-myofibroblast transdifferentiation, and smooth muscle metaplasia. Increasing lesional fibrosis propagates into the neighboring EMI and endometrium. The increased endometrial fibrosis, with ensuing greater tissue stiffness, results in attenuated prostaglandin E2, hypoxia signaling and glycolysis, impairing endometrial repair and causing HMB. Compared with adenomyosis-associated HMB, the mechanisms underlying adenomyosis-associated pain are less understood but presumably involve increased uterine contractility, hyperinnervation, increased lesional production of pain mediators, and central sensitization. Viewed through the prism of ReTIAR, a new imaging technique can be used to diagnose adenomyosis more accurately and informatively and possibly help to choose the best treatment modality.
C/EBP-β contributes to pig endometrial LE receptivity by targeting cell remodeling genes during implantation
Authors: Sun Yan , Yang Yifen , Jiang Ziran , wang Feiyu , Han Kun , Hong Linjun , Cao Jianhua , Yu Mei 
Published: September 2022

In brief
Transforming the endometrial luminal epithelium (LE) into a receptive state is a requisite event for successful embryo implantation. This study suggests the role of a transcription factor in regulating endometrial LE receptivity.

Abstract
The endometrial luminal epithelium (LE) undergoes extensive remodeling during implantation to establish receptivity of the uterus in response to the conceptus signals, such as interleukin 1β (IL1B). But the mechanisms remain to be fully understood. This study investigated the role of CCAAT/enhancer-binding protein β (C/EBP-β) in regulating pig endometrial LE receptivity. Our results showed that C/EBP-β was expressed and activated only in the endometrial LE in an implantation-dependent manner. In addition, C/EBP-β was highly activated at the pre-attachment stage compared to the attachment stage, and its activation was correlated with the expression of IL1B-dependent extracellular signal-regulated kinases1/2-p90 ribosomal S6 kinase signaling axis. Subsequent chromatin immunoprecipitation (ChIP)-sequencing analysis revealed that the binding of C/EBP-β within the promoter was positively associated with the transcription of genes related to cell remodeling. One such gene is matrix metalloproteinase 8 (MMP8), which is responsible for extracellular matrix degradation. The expression of MMP8 was abundant at the pre-attachment stage but dramatically declined at the attachment stage in the endometrial LE. Consistent with C/EBP-β, the expression and activation of MMP8 were limited to the endometrial LE in an implantation-dependent manner. Using ChIP-qPCR and electrophoresis mobility shift assay approaches, we demonstrated that C/EBP-β regulated the expression of the MMP8 gene during implantation. Furthermore, we detected that MMP8 and one of its substrates, type II collagen, showed a mutually exclusive expression pattern in pig endometrial LE during implantation. Our findings indicate that C/EBP-β plays a role in pig endometrial LE receptivity by regulating cell remodeling-related genes, such as MMP8, in response to conceptus signals during implantation.
Towards an Intelligent Code Search Engine
Authors: Kim Jinhan , Lee Sanghoon , Hwang Seung-won , Kim Sunghun 
Published: September 2022

Software developers increasingly rely on information from the Web, such as documents or code examples on Application Programming Interfaces (APIs), to facilitate their development processes. However, API documents often do not include enough information for developers to fully understand the API usages, while searching for good code examples requires non-trivial efforts. To address this problem, we propose a novel code search engine, combining the strength of browsing documents and searching for code examples, by returning documents embedded with high-quality code example summaries mined from the Web. Our evaluation results show that our approach provides code examples with high precision and boosts programmer productivity.
Exploiting Monotonicity in Interval Constraint Propagation
Authors: Araya Ignacio , Trombettoni Gilles , Neveu Bertrand 
Published: September 2022

We propose in this paper a new interval constraint propagation algorithm, called MOnotonic Hull Consistency (Mohc), that exploits monotonicity of functions. The propagation is standard, but the Mohc-Revise procedure, used to filter/contract the variable domains w.r.t. an individual constraint, uses monotonic versions of the classical HC4-Revise and BoxNarrow procedures. Mohc-Revise appears to be the first adaptive revise procedure ever proposed in (interval) constraint programming. Also, when a function is monotonic w.r.t. every variable, Mohc-Revise is proven to compute the optimal/sharpest box enclosing all the solutions of the corresponding constraint (hull consistency). Very promising experimental results suggest that Mohc has the potential to become an alternative to the state-of-the-art HC4 and Box algorithms.
Myopic Policies for Budgeted Optimization with Constrained Experiments
Authors: Azimi Javad , Fern Xiaoli , Fern Alan , Burrows Elizabeth , Chaplen Frank , Fan Yanzhen , Liu Hong , Jaio Jun , Schaller Rebecca 
Published: September 2022

Motivated by a real-world problem, we study a novel budgeted optimization problem where the goal is to optimize an unknown function f(x) given a budget. In our setting, it is not practical to request samples of f(x) at precise input values due to the formidable cost of precise experimental setup. Rather, we may request a constrained experiment, which is a subset r of the input space for which the experimenter returns x in r and f(x). Importantly, as the constraints become looser, the experimental cost decreases, but the uncertainty about the location x of the next observation increases. Our goal is to manage this trade-off by selecting a sequence of constrained experiments to best optimize f within the budget. We introduce cost-sensitive policies for selecting constrained experiments using both model-free and model-based approaches, inspired by policies for unconstrained settings. Experiments on synthetic functions and functions derived from real-world experimental data indicate that our policies outperform random selection, that the model-based policies are superior to model-free ones, and give insights into which policies are preferable overall.
Anatomy of a New Copyright Librarian
Authors: Kendall Susan K. 
Published: September 2022

My journey to working with copyright at the Michigan State University (MSU) Libraries began with images for medical education. I was Coordinator for Health Sciences at the Libraries, during which time instructors creating a new online curriculum asked for clear guidance on images they could include. Over a period of years, I negotiated licenses with major medical publishers to allow image use from our subscription resources for this purpose. Through this project, I grew my expertise and knowledge about copyright issues, which gave me confidence to propose taking on the part-time copyright librarian position when the existing copyright librarian retired. I’m now in the position and enjoy collaborating with people across the MSU Libraries and across subject areas to promote understanding of copyright for teaching, learning, and scholarship.