bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of preparation conditions of a novel low-cost natural bio-sorbent from olive pomace and column adsorption processes on the removal of phenolic compounds from olive oil mill wastewater
Authors: HAYDARI Imane , LISSANEDDINE Amina , AZIZ Khalid , Ouazzani Naaila , MANDI Laila , GHADRAOUI Ayoub El , Aziz Faissal 
Published: February 2022

Abstract
Olive oil mill wastewater (OMWW) poses an undeniable environmental problem due to its high organic loads and phenolic compounds (PCs) content. This study determined the optimal conditions for preparing a new bio-sorbent from olive pomace (OP) and the adsorptive treatment of OMWW by this bio-sorbent. The activation reaction was performed with hydrogen peroxide. The results of the combination effect optimization of the three preparation variables: the activation temperature (°C) X1, the activation time (min) X2 and the impregnation ratio X3, are presented by the response surface methodology (RSM). The maximum adsorption capacity was obtained at activation time 300 min, temperature 80 °C and ratio equal to 6.2:1. The bio-sorbent was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray diffractometer (XRD). The adsorption process performance of this bio-sorbent was examined in batch and fixed-bed columns. An adsorption capacity of 446 mg g-1 has been achieved for 4000 mg L-1 concentration of PCs. The adsorption isotherm and kinetics were consistent with the Langmuir and pseudo-second-order models. Therefore, the Thomas model best fit the fixed bed column experimental data. The bio-sorbent gave a high desorption percentage of PCs, which was above 70% using HCl (0.1M).
Recanalization of thrombosed aneurysmal hemodialysis arterovenous fistulas using a hybrid technique based on data from a single center
Authors: Wu Yong-gui , Liu Wei , Wu Meng , Wang Xu , Huang Xiao-kang , Cai Wen-jiao , Ding Teng-yun , Duan Liang-liang , Qiao Rui 
Published: February 2022

Abstract
Objective: To explore the technical specifications and clinical outcomes of thrombosed aneurysmal haemodialysis arteriovenous fistula (AVF) treated with ultrasound-guided percutaneous transluminal angioplasty combined with minimal aneurysmotomy.Methods: This case series study included 11 patients who had thrombosed aneurysmal AVF and underwent salvage procedures over a 13-month period. All procedures were performed under duplex guidance. Minimal aneurysmotomy was performed, along with manual thrombectomy and thrombolytic agent infusion, followed by angioplasty to macerate the thrombus and sufficiently dilate potential stenoses. A successful procedure was defined as immediate restoration of flow through the AVF. Results: The 11 patients (four males and seven females) had a mean age of 49.6 years ± 11.9 years. Six patients (54.5%) had two or more aneurysms. The mean aneurysm maximal diameter was 21.5 mm (standard deviation: ± 5.0 mm), and the mean thrombus length was 12.9 cm (8–22 cm). Ten (83.3%) of the 12 procedures were technically successful. The mean duration of operation was 150.9 minutes (standard deviation: ± 34.2 minutes), and mean postoperative AVF blood flow was 728.6 ml/min (standard deviation: ± 53.7 mi/min). The resumption of hemodialysis was successful in all 11 cases, with a clinical success rate of 100%. The primary patency rates were 90.0% over a mean follow-up time of 6.3 months (3–12 months) and 75.0% at three and four months. The secondary patency rates were 90.4% at three and four months. Conclusion: A hybrid approach combining ultrasound-guided percutaneous transluminal angioplasty and minimal aneurysmotomy might be a safe and effective method for thrombosed aneurysmal AVF salvage.
Targeted Exonic Sequencing Identifies Novel Causes of Disease in a Cerebral Small Vessel Disease Cohort
Authors: Dunn Paul , Maksemous Neven , Smith Robert , Sutherland Heidi , Haupt Larisa , Griffiths Lyn 
Published: February 2022

Abstract
Cerebral small vessel diseases (CSVDs) are a set of conditions that affect the small blood vessels in the brain and can cause severe neurological pathologies such as stroke and vascular dementia. The most common monogenic CSVD is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) which is caused by mutations in NOTCH3. However, only 15-20% of CADASIL cases referred for genetic testing have pathogenic mutations in NOTCH3. Investigation of other monogenic forms of CSVD caused by HTRA1, COL4A1, COL4A2, CTSA, TREX1 and GLA were rarely requested as follow-up to CADASIL diagnostic testing. We performed whole exome sequencing for 50 individuals suspected of having CADASIL, but did not exhibit a disease-causing mutation in NOTCH3, and applied targeted analysis of all monogenic forms of CSVD including NOTCH3, HTRA1, COL4A1, COL4A2, CTSA, TREX1 and GLA to look for rare, protein-altering mutations. We identified three mutations affecting the Collagen type IV genes in three individuals likely to be causative of CSVD. This suggests that screening for all monogenic forms of CSVD when one monogenic form is clinically suspected may improve diagnosis in clinically suspected monogenic CSVD. However, despite these findings, the majority of NOTCH3 negative CSVD cases did not have candidate mutations in known CSVD genes, suggesting that additional genetic factors contributing to the disease are yet to be identified.
Post-Partum Abdominal Wall Insufficiency Syndrome (PPAWIS): Lessons learned from a single surgeon’s experience based on 200 cases
Authors: Śmietański Maciej , Śmietańska Anna , Zamkowski Mateusz 
Published: February 2022

Abstract
BackgroundPost-partum abdominal wall insufficiency with rectus diastasis is present in over 30% of women after pregnancy. Little is known about how PPAWI affects the social, sexual life and self-esteem of patients. This study was designed to evaluate the safety of onlay mesh combined with abdominoplasty and its impact on the well-being of the patients.MethodTwo hundred patients with PPAWI underwent surgery with onlay mesh and abdominoplasty. The safety of the procedure was assessed by postoperative complications, time of hospitalization and time of drainage. Before the operation and 6 months later, a questionnaire asking about the patient’s sexual and social life and the presence of back pain was completed. The cosmetic effect was assessed separately.ResultsThe onlay procedure with abdominoplasty was found to be safe and fast. The mean operation time was 82 min, and the drainage time was 2.1 days. In this group <2% postoperative complications were noted. There were no recurrences within the 6 month. Significant improvements in social and sexual life and the level of self-esteem were noted. Back pain was relieved or minimalized in all patients. The cosmetic effect was insufficient for 2 patients (1%).Conclusion:PPAWI can be treated safely with onlay mesh and abdominoplasty. The patients’ symptoms were strongly correlated with the morphological status of the front abdominal wall and improved after the procedure. The authors are the first to propose PPAWI syndrome as a complex disorder with a disease classification, which can help patients with their choice of proper surgical intervention.
A general framework for selecting work participation outcomes in intervention studies among persons with health problems.
Authors: Ravinskaya Margarita , Verbeek Jos H. , Langendam Miranda W. , Madan Ira , Verstappen Suzanne M.M. , Hulshof Carel T.J. , Hoving Jan L. , Kunz Regina 
Published: February 2022

Abstract
Background: Work participation is important for health and can be considered as engagement in a major area of life which is of significance for most people, but it can also be thought of as fulfilling or discharging a role. Currently, academic research lacks a comprehensive classification of work participation outcomes. The International Classification of Functioning is the foremost model in defining work functioning and its counterpart work disability, but it does not provide a critical (core) set of outcomes. It is important to standardize the definitions and the nomenclature used in the research of work participation, so that the outcomes of studies are comparable, and practitioners and guideline developers can better decide what works best. As work participation is a broad umbrella term including outcome categories which need unambiguous differentiation, a framework needs to be developed first.Aim: To propose a framework which can be used to develop a generic core outcome set for work participation.Methods: First, we performed a systematic literature search on the concept of (work) participation, perspectives on how to measure it, and existing classifications for outcome measurements. Next, we derived criteria for the framework and proposed a framework based on the criteria. Last, we applied the framework to six case studies as a proof of concept. Results: Our literature search provided 2106 hits and we used 59 studies for full-text analysis. Based on the literature and the developed criteria we propose four overarching outcome categories: (1) initiating employment, (2) having employment, (3) increasing or maintaining productivity at work and (4) return to employment. These categories appeared feasible in our proof-of-concept assessment with six different case studies. Conclusion: We propose to use the framework for work participation outcomes to develop a core outcome set for intervention studies to improve work participation.
Gender Recognition Of Avalokitesvara In China Based On Vggnet
Authors: Huang Yongwen , Chen Dingding , Wang Haiyan , Wang Lulu 
Published: February 2022

Abstract
Many people are confused with Avalokitesvara’s ambiguous gender. Can we use computer vision to help us recognize it objectively and efficiently? In this paper, VGGNet is applied to propose an automatic gender recognition system. To validate the efficiency of the proposed method, abundant experiments are implemented on Buddhist images of Dazu Rock Carvings, Mogao Caves, and Yungang Grottoes. The experimental results demonstrate its efficiency. Firstly, it is effectively applied to gender recognition on both non-Buddhist and Buddhist images. Compared with five classical feature extraction methods, the VGG-based system performs not much better on non-Buddhist image recognition, but superior on Buddhist image recognition. Furthermore, the experiments are also carried out on three different training datasets, real-world facial datasets as CUHK, IMFDB and CAS-PEAL. The unsatisfactory results based on IMFDB indicate that it is not valid for Indian facial images applied as a training set in gender recognition on Buddhist image in China. With the sinicization of Buddhism, there were more Chinese rather than Indian characteristics for Buddhist image in China. The results based on CAS-PEAL are more robust than those based on CUHK, as the former is mainly composed of adult facial images, and the latter consists of student facial images. It gives the evidence that Buddha and Bodhisattva (Avalokitesvara included) were adult image in Buddhist art. The last but the most meaningful is that besides the time factor, the geographical impact should not be ignored when we talk about the gender transformation of Avalokitesvara in China. The gender of Avalokitesvara frescoes in Mogao Caves drawn in the Sui, Tang, Five, Song and Yuan dynasties were always with prominent male characteristics (tadpole-like moustache), while bodhisattvas in Yungang Grottoes engraved in the Northern Wei Dynasty were feminine even though they were made earlier than those in Mogao Caves. It is quite different from the common idea that the feminization of Avalokitesvara occurred in the early Tang Dynasties and completely feminized in the late Tang Dynasty. Both the quantitative results and image analysis indicate that it is quite a complicated issue for the feminization of Avalokitesvara in China.
Health Risks and Musculoskeletal Problems of Smartphone-game Elite eSport Players: a Cross-sectional Descriptive Study
Authors: Lam Wing-Kai , Liu Rui-Tan , Chen Bob , Huang Xin-Zhou , Yi Jie , Wong Duo Wai-Chi 
Published: February 2022

Abstract
Background: Smartphone eSports athletes sit in the same posture for a prolong period, contributing to significant health risks. This study investigated the health profile, fatigue, pain and complaints, and musculoskeletal problems among full-time smartphone eSports athletes.Methods: We recruited 50 participants from the ten teams of a top-tier league tournament, with each team for five players. A survey was conducted to evaluate the fatigue pattern, pain level, and complaints. Physical assessment was also conducted by physiotherapists. A descriptive analysis was conducted to evaluate the health profile (BMI, fat ratio), fatigue, number of complaints and musculoskeletal problems. The associations of career duration with BMI, fat ratio, and the total number of confirmed injuries were then performed using a Spearman’s rank correlation test. Results: About 46% and 44% of participants felt tired, while 34% and 58% experienced eyestrain frequently and occasionally. More than 30% of the participants reported headache, neck pain, trigger finger and rhinitis. Physiotherapists confirmed head-and-trunk injuries on 90% of the participants, with a quarter of them suffering at least one of these four pains. Longer career duration of eSports may be associated with a reduction in BMI (r=-0.272, p=0.056). The duration of career has no significant association with smoking habit (p=0.666), alcohol habit (p=0.655), coffee habit (p= 0.946), rounds of game that can maintain concentration (p=0.253), ease of eyestrain (p=0.569), tiredness (p=0.510), dizziness (p=0.071), and leg numbness (p=0.318).Conclusion: The findings of this study stressed the significance of eSports injuries and implicated preventive measures for both athletes and phubbers.
TBM Tunneling Problems through Subterranean Rivers: An Evaluation of Nowsud Tunnel in the Iran
Authors: Taherian Abdolreza 
Published: February 2022

Abstract
Fault induced subterranean rivers create a major challenge of tunnel construction. They arises serious problems such as TBM performance, structural stability of segmental rings, destruction of TBM components, large water inflow and regional drawdown. Since, the faulted cavity is one of the infrequent adverse geological conditions, not much executive experience has been provided. The TBM of Nowsud tunnel encountered the fault cavities in three places wherein groundwater inrushes from 4.0 to 0.36 m3/s and delayed for 8 months. In each cavity, the main items such as prospecting methods, water inrush and drawdown, type of TBM damages, TBM performance, managing of TBM advance in relation to water discharge, estimation of rockfall impact force and method of segments strengthening were considered. It is found that the fault cavities create in extension part of strike slip faults. In large faults, the TBM could encounter with accessory cavities which hydraulically interconnected to main cavity. Based on gained experiences, TBM excavation along with probe drillings, TSP and appraisal of water discharge, eliminates the hazard of adverse condition. The TBM submerging and damage of other equipment occurs in short term transient part of flow regime while the need to run and capacity of the pumping system are controlled by steady state part. Since, the most of active and passive forces, acting on the TBM, were absent, the re-advancement carried out by quasi-single mode. In this case, the excessive pressures cause the damage stepping of segmental rings. The rockfall impact load was calculated by analytical and numerical methods.
Work Impairment in Patients with Depression: A Descriptive Cross Section Study
Authors: Elmetwaly Miada , El-Gilany Abdel-Hady , Elwasify Mohamed , Elkalla Ibrahem 
Published: February 2022

Abstract
Background
Depression significantly impairs all aspects of the patient’s life. Work comes on top of the list. This greatly affects productivity nationally and internationally. This study aimed to determine work impairment among patients with depression, and its associated factors.
Methods
This is an observational descriptive cross-sectional study conducted on 380 patients with depression who attended Mansoura University Hospitals, Egypt. Depression diagnosis was based on structured clinical interview using Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and Young Mania Rating Scale (YMRS). Data were collected using a questionnaire. Sociodemographic, occupational, and clinical factors were inquired about. Lam Employment Absence and Productivity Scale (LEAPS) was used to calculate work impairment in patients with depression.
Results
more than half of the study participants (52.4%) had moderate, severe, or very severe work impairment. Independent predictors of moderate to very severe impairment are insufficient income, morning shift work, missed 5 or more work hours during the past 2 weeks, Hamilton Depression Rating Scale (HDRS) of 25 or more, 2 or more depressive episodes, 5 or more depressive symptoms, and death thoughts.
Conclusions
Depression greatly impacts patients’ ability to work. Periodic screening for work impairment especially among high-risk groups allows for early detection and timely intervention to reserve quality of life and work performance.
Food Information Traceability for the Supply Chain of Online Ordering Platform Based on Commercial IoT
Authors: Zhang Xin 
Published: February 2022

Abstract
As more and more people pay attention to food safety, the research on food traceability is becoming popular. The information traceability of the food supply chain is made more difficult by the fact that the online shopping platform comprises not only a big number of merchants, but also a high number of users, raising the chance of misunderstanding between different parties. To ensure food safety, this article proposes and analyzes a commercial IoT-based food supply chain information traceability system. Users need just to scan the traceability source code with the APP device to acquire information about the food's origin, processing, and merchants. They can also order uniform food ingredients for dispersed small merchants to assure food safety. The developed system consists of two components: a purchase system for food and a processing system for food. A database connects the two systems, and they are then incorporated into the food traceability system. The numerical results reveal that our proposed system has a more than 90% accuracy rate for source code traceability as well as a satisfying performance robustness with a large number of concurrently logged-in users.
Implementation of online video consultations in a regional health network: A management feasibility analysis from an orthopedic perspective
Authors: Back David Alexander , Estel Katharina , Pförringer Dominik , Tsitsilonis Serafeim , Bachner Johann , Willy Christian , Becker Horst-Peter 
Published: February 2022

Abstract
Background: Regional health care networks with interfaces between clinics, general practitioners and patients can act faster when utilizing digital measures. This manuscript describes the establishment of an online video consultation service in a clinic and its broad health care region to exemplify challenges and solutions for potential future approaches from a management perspective.Methods: The underlying pilot project was planned and implemented for follow-up monitoring and consultative presentation of orthopedic and trauma patients within the Bundeswehr Medical Service from 2018 to 2020. With predominantly positive evaluation results regarding quality and acceptance among users, this research investigated aspects of organizational and process management within total quality management, strategic control and change management approaches.Results: The affected main and subprocesses of patient treatment could be streamlined by the project, as physician recommendations and arrangements could be accelerated and patient travel could be significantly reduced. A SWOT and portfolio analysis showed a high potential for improving existing patient treatment processes for health care enterprises via the use of digital technology. The involved staff should be strategically included at an early stage and continuously involved. By means of a PDCA cycle, the processes of the given project could be exemplarily illustrated with an outlook in the future.Conclusions: It has proven successful to consciously use management approaches to establish telemedical integrated care structures in a health region. Recommendations for the strategic introduction of an online video consultation for regional network strengthening and care development for a patient-oriented increase in efficiency could be compiled.
2-Phenyl Substituted Benzimidazole Derivatives: Design, Synthesis, and Evaluation of Their Antiproliferative and Antimicrobial Activities
Authors: Ersan Ronak Haj , Kuzu Burak , Yetkin Derya , Alagoz Mehmet Abdullah , Dogen Aylin , Burmaoglu Serdar , Algul Oztekin 
Published: February 2022

Abstract
The inability to meet the desired outcomes of anticancer treatment and decrease in treatment success of bacterial and fungal infections accelerated research in these areas. Our research group has conducted numerous studies, especially on benzimidazole ring systems’ antiproliferative and antimicrobial activities. In this study, the antiproliferative activity of benzimidazole compounds was tested against A549, A498, HeLa, A375, and HepG2 cancer cell lines by MTT assay. All compounds exhibited good to potent antiproliferative activity against all tested cancer cell lines. Compounds 30 and 46 were especially active against HeLa and A375 cancer cell lines with IC50 values in the range of 0.02-0.04 µM. In contrast, compounds 67 and 68 were active against A549 and A498 cancer cell lines with an IC50 value of 0.08 µM. These compounds (30, 46, 67, and 68) were less toxic to normal human cells than the positive control compound methotrexate, which was screened to determine its toxicity against normal cell lines (HEK293). In the second part of the study, all compounds were tested to demonstrate their antimicrobial properties. All compounds exhibited moderate activity against all tested bacteria and fungi. However, some phenoxymethyl derivatives (69 and 74) were most active against Candida (<3.90 µg/mL).
One-component quantum mechanics and dynamical leakage-free paths
Authors: Wu Lian-Ao , Jing Jun 
Published: February 2022

Abstract
We derive an exact one-component equation of motion for the probability amplitude of a target time-dependent state, and use the equation to reformulate quantum dynamics and control for both closed and open systems. Using the one-component equation, we show that an unexpected time-dependent leakage-free path can be induced and we capture the essential quantity in determining the effect of decoherence suppression. Our control protocol based on the nonperturbative leakage elimination operator provides a unified perspective connecting some subtle, popular and important concepts of quantum control, such as dynamical decoupling, quantum Zeno effect, and adiabatic passage. The resultant one-component equation will promise significant advantages in both quantum mechanics and control.