bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wardens of Civilisation: The Political Ecology of Australian Far‐Right Civilisationism
Authors: McFadden Alexandra 
Published: November 2022

AbstractThe notion of a superior “civilisation” has been a hallmark of the politics of Western institutions and fringe white supremacists alike. Known ideologically as “civilisationism”, it has occupied a prominent position in the ideology of the Australian far‐right. Paying tribute to their settler‐colonial origins, the far‐right has consistently promoted “white civilisation”, even inspiring terrorist attacks. Despite this propensity for violence, far‐right civilisationism remains largely unexplored. Through investigating a dataset of Australian far‐right content, this paper reveals civilisationism as a significant part of their ideology, an ideology which relies on the idealisation of European technologies and environments to render Indigenous land and people uncivilised. A critical narrative analysis of the data illustrates the ways that these ecological factors are drawn into narrative to articulate Australian far‐right civilisationism, an ideology inseparable from the political ecology of European history and colonialism, that today represents a particularly virulent version of its legacy.
Interspecies normalization of dose‐response relationship for adeno‐associated virus‐mediated haemophilia gene therapy—Application to human dose prediction
Authors: Zou Peng 
Published: November 2022

AimsThe aim of this study is to develop an approach to predict human dose–response relationship and first‐in‐human (FIH) dose for adeno‐associated virus (AAV)‐mediated haemophilia gene therapy.MethodsPreclinical dose–response relationships of 7 AAV vectors were normalized to a species‐invariant scale using an exponent of 0.25, and the normalized dose–response relationship was then used for FIH dose prediction. The performance of this dose–response normalization approach for FIH dose prediction was compared to that of direct body weight‐based dose (vg/kg) conversion and allometric scaling approaches.ResultsA power regression analysis of normalized factor VIII (FVIII) or factor IX (FIX) showed a moderate‐to‐strong correlation between FVIII or FIX and vector dose across 3 species (R2 ranged 0.59 to 0.89), indicating it was feasible to normalize dose–response in multiple species to a species‐invariant scale. When the mean values of normalized FVIII or FIX at each dose level were used for regression, the R2 values of the 7 vectors were improved to be >0.84. The FIH doses predicted by the 3 approaches were ranked as allometric scaling > dose–response normalization > direct vg/kg conversion for all vectors except for rAAV2‐hAAT‐FIX and scAAV2/8‐LP1‐hFIXco. Among the 7 vectors, dose–response normalization, direct vg/kg conversion and allometric scaling generated accurate FIH dose predictions for 2, 2 and 3 vectors, respectively.ConclusionThis study first demonstrated that it is feasible to normalize dose–response relationship of AAV‐mediated haemophilia gene therapy in multiple species to a species‐invariant scale. The normalized dose‐response relationship from preclinical species was successfully extrapolated to patients for FIH dose prediction.
Evaluation of the Mayo Additive Staging System in patients with newly diagnosed multiple myeloma: A real‐world analysis
Authors: Chen Haimin , Shi Haotian , Zhou Nian , Yu Wenjun , Wu Lixia , Peng Rong , Wei Wei , Wang Dongjiao , Zhou Fan 
Published: November 2022

AbstractObjectivesRecently, the Mayo Clinic introduced a new staging system (the Mayo Additive Staging System [MASS]) for patients with newly diagnosed multiple myeloma (NDMM) based on the number of high‐risk (HR) abnormalities, including HR IgH translocations, 1q gain/amplification, chromosome 17 abnormalities, International Staging System (ISS)‐III, and elevated lactate dehydrogenase. Patients with 0, 1, or ≥2 HR abnormalities were defined as stage I, II, or III, respectively. We aimed to validate the real‐world prognostic value of the MASS.MethodsWe retrospectively analyzed the cytogenetic and laboratory results of 544 patients with NDMM at a single center.ResultsNinety (16.5%) patients had no HR factors (MASS I), 193 (35.5%) had 1 HR factor (MASS II), and 261 (48%) had ≥2 HR factors (MASS III). The median progression‐free survival (PFS) and overall survival (OS) times were 48, 28, and 20 months and 137, 73, and 39 months in the three groups, respectively (p < .001). In the subgroup analysis, patients had different OS outcomes based on the MASS when grouped by age, renal function, or therapeutic regimens. The MASS identified patients with the worst outcomes among those rated revised ISS II.ConclusionThe MASS system is a reliable risk stratification tool for patients with NDMM in real‐world clinical practice.
Functional disorders as a common motor manifestation of COVID‐19 infection or vaccination
Authors: Fung Wilson K. W. , Sa'di Qais , Katzberg Hans , Chen Robert , Lang Anthony E. , Cheung Angela M. , Fasano Alfonso 
Published: November 2022

AbstractBackground and purposeThere have been over 500 million confirmed cases of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), also known as coronavirus disease 2019 (COVID‐19), across the globe. To date, a broad spectrum of neurological manifestations following acute infections as well as COVID‐19 vaccines have been reported. The aim of this study was to describe the spectrum of neurological manifestations seen in the ‘COVID‐19 clinic’ established in a tertiary Movement Disorders clinic.MethodsIn this consecutive case‐series study over the period March 2020–January 2022, clinical information regarding demographic data, clinical history and examination findings, investigation results and video recordings of outpatients with motor manifestations associated with COVID‐19 infection or vaccination were reviewed.ResultsTwenty‐one adult patients were reviewed in this ad hoc clinic at Toronto Western Hospital. The majority of the patients were female (76%) and the mean (range) age was 50.7 ± 17.2 (21–80) years. Nine patients (43%) presented with motor manifestations following COVID‐19 infection. Twelve patients (57%) developed neurological symptoms following at least one dose of the mRNA or viral vector‐based COVID‐19 vaccine. The most common manifestation observed was a functional movement disorder (43%). The vaccine group demonstrated a higher number of functional disorders compared to the infection group (58% vs. 22%; p = 0.08).ConclusionFunctional motor manifestations can be associated with COVID‐19 and are likely to be under‐reported. In view of the co‐existence of functional symptoms, movement disorders and mental health conditions observed in this study, we would advocate the use of dedicated COVID‐19 Neurology clinics with full access to an experienced multidisciplinary team.
Identification of reversed portal flow on 4DCT and of factors contributing to reversed portal flow in patients with liver cirrhosis and portosystemic shunt before interventional radiology procedures
Authors: Kageyama Ken , Yamamoto Akira , Jogo Atsushi , Sohgawa Etsuji , Izuta Shinichiro , Himoto Daisuke , Kakimi Akihiko , Kita Ryuichi , Miki Yukio 
Published: November 2022

AbstractAimPatients with liver cirrhosis and portosystemic shunt occasionally develop reversed portal flow in the portal venous system. The factors contributing to reversed portal flow in these patients remain unclear. The aim of this study was to identify factors contributing to reversed portal flow in patients with portosystemic shunts based on four‐dimensional computed tomography (4DCT), which visualized flow dynamics in the portal venous system.MethodsData from 34 consecutive patients with portosystemic shunts who had undergone 4DCT before interventional radiology procedures were retrospectively investigated in this study. Uni‐ and multivariate analyses were performed to identify factors contributing to reversed portal flow.ResultsFlow dynamics could be visualized on 4DCT in 32 of the 34 patients. Fifteen patients had forward portal flow; 17 had reversed portal flow. The main portal, splenic, and superior mesenteric veins displayed reversed portal flow in five, 12, and five vessels, respectively. Portosystemic shunt originating from splenic and superior mesenteric veins, worse albumin‐bilirubin score, and small main portal vein diameter were significant factors contributing to reversed portal flow in both univariate (p = 0.049, p = 0.027, and p = 0.002) and multivariate (odds ratio [OR] 6.345, p = 0.012; OR 4.279, p = 0.039; and OR 5.516, p = 0.019) analyses.ConclusionsThe reversed portal flow was visualized on 4DCT. Portosystemic shunt originating distant to the liver, worse albumin‐bilirubin score, and small diameter of the main portal vein were factors contributing to reversed flow in the portal venous system.
Epidemiology, comorbidities at diagnosis and outcomes associated with HIV late diagnosis from 2010 to 2019 in a Belgian reference centre: A retrospective study
Authors: Severin Simon , Delforge Marc , De Wit Stéphane 
Published: November 2022

AbstractObjectivesOur objective was to investigate the demographic factors, comorbidities, and outcomes of patients with a late diagnosis (LD) of HIV in a Belgian HIV reference centre.MethodsAll patients with HIV who presented for care between 2010 and 2019 were included. They were excluded if time between diagnosis and presentation or first CD4 count exceeded 6 months or if they had previously received antiretroviral therapy (ART). LD was defined as a CD4 cell count ≤350/mm3or an AIDS‐defining event at diagnosis. Data were retrospectively collected and included data on demographic variables, cardiovascular risk factors, comorbidities at diagnosis, first prescribed ART, and outcomes. Logistic regression was used to determine factors associated with LD.ResultsOf 1078 patients, 427 (39.6%) were LD. In multivariable analysis, the following factors were associated with LD: non‐homosexual transmission route, being born in Sub‐Saharan Africa (SSA), and age ≥35 years. Prevalence at diagnosis of malignancies, diabetes, and cardiovascular diseases did not differ between non‐LD and LD, whereas renal impairment was more frequent in LD. In univariable analysis, high‐density lipoprotein (HDL) cholesterol <40 mg/dL and estimated glomerular filtration rate <60 ml/min were associated with LD; in multivariable analysis, only HDL cholesterol <40 mg/dL was associated. Patients with LD experienced more adverse events leading to a switch in ART, virological failure, and death during follow‐up.ConclusionLD remains common in our centre, especially in non‐homosexual patients and those born in SSA. Although not associated with an important burden of comorbidities at diagnosis, it still results in poorer outcomes, emphasizing the need to expand coverage and access to HIV testing.
The adverse impact of ecotropic viral integration site‐1 (EVI1) overexpression on the prognosis of acute myeloid leukemia with KMT2A gene rearrangement in different risk stratification subtypes
Authors: Liu Xin‐xin , Pan Xin‐an , Gao Meng‐ge , Kong Jun , Jiang Hao , Chang Ying‐jun , Zhang Xiao‐hui , Wang Yu , Liu Kai‐yan , Chen Zhong , Zhao Xiao‐su , Huang Xiao‐jun 
Published: November 2022

AbstractIntroductionAML patients with KMT2A‐MLLT3 and other 11q23 abnormalities belong to the intermediate and high‐risk level groups, respectively. Whether the poor prognostic value of Ecotropic Viral Integration site‐1 (EVI1) overexpression suits either the subtypes of KMT2A‐MLLT3 or Non‐KMT2A‐MLLT3 AML patients (intermediate and high risk group) needs to be further investigated.MethodsWe retrospectively analyzed the clinical characteristics of 166 KMT2A‐r and KMT2A‐PTD AML patients.ResultsFor the Non‐KMT2A‐MLLT3 group, patients in the EVI1‐high subgroup had shorter OS and DFS and higher CIR than those in the EVI1‐low subgroup (p = .027, p = .018, and p = .020, respectively). Additionally, both KMT2A‐MLLT3 and Non‐KMT2A‐MLLT3 patients who received chemotherapy alone had poorer prognosis than patients who also received allogeneic hematopoietic stem cell transplant (allo‐HSCT) regardless of their EVI1 expression level (all p < .001). For transplanted patients with KMT2A‐MLLT3 or Non‐KMT2A‐MLLT3 rearrangement, the EVI1‐high subgroup had worse prognosis than the EVI1‐low subgroup (all p < .05). The 2‐year CIR of the KMT2A‐MLLT3 and Non‐KMT2A‐MLLT3 groups with high EVI1 expression was high (52% and 49.6%, respectively). However, for patients with low EVI1 expression, the 2‐year CIR of transplanted patients with KMT2A‐MLLT3 and Non‐KMT2A‐MLLT3 was relatively low.ConclusionsOur study showed that for the Non‐KMT2A‐MLLT3 group, the EVI1‐high group had shorter OS and DFS than the EVI1‐low group. High EVI1 expression showed an adverse effect in AML with KMT2A rearrangement in different risk stratification subtypes. For the EVI1‐high patients with non‐KMT2A‐MLLT3 rearrangement, other novel regimens towards relapse should be taken into consideration.
Effects of neutrophil‐to‐lymphocyte ratio, serum calcium, and serum albumin on prognosis in patients with diabetic foot
Authors: Xu Su , Wang Yijia , Hu Zhensheng , Ma Ling , Zhang Fan , Liu Pei 
Published: November 2022

AbstractThe purpose of this study is to investigate the predictive value of neutrophil‐to‐lymphocyte ratio (NLR), serum calcium, and serum albumin on the prognosis of patients with diabetic foot. A total of 156 patients who were treated in the Department of Burn and Plastic Surgery of Qilu Hospital of Shandong University from 1 January 2014 to 1 August 2020 were selected. All the patients were randomly divided into a healing group, minor amputation group, major amputation group, and death group according to their treatment outcomes. The levels of NLR, serum calcium and serum albumin in each group were examined and compared. The correlations between NLR, serum calcium, and serum albumin with the prognosis of diabetic foot were analysed to investigate their predictive effects on the prognosis of diabetic foot. The results of one‐way ANOVA showed that among the 4 groups of patients, the difference in NLR values between the healing group and the minor amputation group was slightly smaller, but they were significantly different from the major amputation group and the death group, respectively. There was no significant difference in serum calcium levels between the healing group and the minor amputation group, but the serum calcium levels of the major amputation group and the death group gradually decreased. The levels of NLR in the 4 groups gradually increased, while the albumin levels gradually decreased. Spearman's rank correlation test indicated that NLR was significantly related to the prognosis of patients with diabetic foot. The group with higher NLR had a worse prognosis in diabetic foot patients. Serum calcium and serum albumin were strongly correlated with the prognosis of patients with diabetic foot. The group with lower serum calcium and serum albumin values had a worse prognosis in diabetic foot patients. The areas under the receiver operator characteristic curve of NLR, serum calcium and serum albumin were 0.901, 0.803, and 0.816, respectively. NLR, serum calcium and serum albumin can be used as reliable indicators to predict the prognosis of diabetic foot. Preoperative diabetic foot patients with higher NLR values or lower serum calcium and serum albumin have a poorer prognosis.
Selection on sperm size in response to promiscuity and variation in female sperm storage organs
Authors: Cramer Emily R. A. , Yilma Zelealem B. , Lifjeld Jan T. 
Published: November 2022

AbstractSperm cells are exceptionally morphologically diverse across taxa. However, morphology can be quite uniform within species, particularly for species where females copulate with many males per reproductive bout. Strong sexual selection in these promiscuous species is widely hypothesized to reduce intraspecific sperm variation. Conversely, we hypothesize that intraspecific sperm size variation may be maintained by high among‐female variation in the size of sperm storage organs, assuming that paternity success improves when sperm are compatible in size with the sperm storage organ. We use individual‐based simulations and an analytical model to evaluate how selection on sperm size depends on promiscuity level and variation in sperm storage organ size (hereafter, female preference variation). Simulations of high promiscuity (10 mates per female) showed stabilizing selection on sperm when female preference variation was low, and disruptive selection when female preference variation was high, consistent with the analytical model results. With low promiscuity (2–3 mates per female), selection on sperm was stabilizing for all levels of female preference variation in the simulations, contrasting with the analytical model. Promiscuity level, or mate sampling, thus has a strong impact on the selection resulting from female preferences. Furthermore, when promiscuity is low, disruptive selection on male traits will occur under much more limited circumstances (i.e. only with higher among‐female variation) than many previous models suggest. Variation in female sperm storage organs likely has strong implications for intraspecific sperm variation in highly promiscuous species, but likely does not explain differences in intraspecific sperm variation for less promiscuous taxa.
Gestational glycosuria, proteinuria, and borderline hypertension in pregnancy are predictors for the later onset of maternal chronic disease
Authors: Hosoya Satoshi , Ogawa Kohei , Morisaki Naho , Okamoto Aikou , Arata Naoko , Sago Haruhiko 
Published: November 2022

AbstractAimAlthough hypertensive disorders of pregnancy and gestational diabetes mellitus (DM) are risk factors for hypertension, DM, and kidney disease in later life, the association of gestational glycosuria, proteinuria, and borderline hypertension with these chronic diseases has been unclear.MethodsThis cross‐sectional study was conducted between April 2017 and November 2020 at a Japanese tertiary hospital. Three variables listed in the Maternal and Child Health Handbook were analyzed: glycosuria, proteinuria, and systolic blood pressure (<130, 130–139, and ≥ 140 mmHg) during pregnancy. The incidences of DM, kidney disease, and hypertension self‐reported by mothers of pregnant women on a questionnaire were assessed with logistic regression analysis.ResultsThe 312 women completed the questionnaires an average of 35.8 ± 4.2 years after delivering their daughters. Risk for DM was significantly increased among women with glycosuria (adjusted odds ratio [aOR], 3.62; 95% confidence interval [CI], 1.21–10.9), and risk for kidney disease was significantly increased among women with proteinuria (aOR, 4.07; 95% CI, 1.29–12.9). Risk for hypertension was significant in women whose blood pressures were ≥ 140 mmHg (aOR, 4.26; 95% CI, 1.96–9.24), but the association between blood pressures of 130–139 mmHg and hypertension was not significant (aOR, 1.72; 95% CI, 0.95–3.11); however, a significant positive trend (p < 0.001) between increasing blood pressure and hypertension was observed.ConclusionsGestational glycosuria, proteinuria, and increased blood pressure were associated with the development of maternal chronic diseases. These standard and inexpensive assessments may improve lifelong health management in women.
Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study
Authors: Uniken Venema Julia Anne Margarethe , Bosschieter Pien Fenneke Nicole , Hoekema Aarnoud , Plooij Joanneke Marielle , Lobbezoo Frank , de Vries Nico 
Published: November 2022

AbstractBackgroundMandibular Advancement Devices (MAD's) are oral appliances commonly used in treatment of Obstructive Sleep Apnea (OSA). OSA severity and certain other factors, such as BMI and neck circumference, correlate with MAD therapy success. So far, the predictive value of dental parameters, such as dental profile, molar‐classification, overjet, overbite, maximal retrusion, maximal protrusion and protrusive range, has not been fully investigated.ObjectivesWe aimed to investigate whether dental parameters influence OSA severity and MAD therapy outcome and could therefore be helpful in phenotyping OSA patients. Furthermore, we studied the predictive power of dental parameters for OSA severity and successful MAD therapy. We hypothesise that specific dental parameters correlate with more severe OSA and with more successful MAD treatment.MethodsWe performed a cohort study, including OSA patients diagnosed by polysomnography (PSG). Dental parameters were collected. Objective treatment outcome was collected by performing a PSG with MAD after three months of therapy. Differences between OSA severity groups and MAD treatment outcomes were analysed and dental parameters were correlated between groups.ResultsThe relation between dental parameters and OSA severity was analysed in 143 patients, fifty patients had a PSG with MAD in situ after a 3‐month therapy. The median baseline Apnea Hypopnea Index (AHI) significantly reduced from 17.6 (8.7–29.3) to 11.1 (5.5–17.5). Overbite and maximal retrusion differed significantly between mild, moderate and severe OSA. Other dental parameters did not differ significantly between the groups, nor correlated with OSA severity or MAD treatment outcome.ConclusionIn this study, no correlation between dental parameters and OSA severity or MAD treatment outcomes was found. Therefore, screening patients for OSA and MAD treatment outcome based on dental parameters is currently not possible.
TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function
Authors: Huang Yunyi , Chen Zhipei , Chen Xuanyi , Chen Xiaohua , Xu Meng 
Published: November 2022

AbstractBackground34‐kDa translocase of the outer mitochondrial membrane (TOMM34) has been reported highly expressed in many cancers and is positively correlated to poorer prognosis. Our prior study showed TOMM34 is highly expressed in oral squamous cell carcinoma (OSCC) and is closely related to TNM classification and tumor size. TOMM34 is also associated with lymph node metastasis and poorer overall survival and disease‐free survival in HPV‐negative OSCC.MethodsWe knocked down TOMM34 in OSCC cells (SCC15, HPV positive; Cal27, HPV negative) with siRNA and over‐expressed with plasmids. The effects of TOMM34 on cell proliferation, migration and invasion abilities were detected by EdU assay, CCK‐8 assay, wound‐healing assay, and Transwell assay. We also detected the mitochondrial morphology and the intracellular Reactive Oxygen Species (ROS) level by fluorescence staining and flow cytometry. Finally, we monitored the protein levels of ERK pathway‐related molecules.ResultsTOMM34 knockdown decreased the proliferation in SCC15 and Cal27, and weakened the migration and invasion abilities as well. Mitochondria became shorter, in the shape of dots or short rods, suggesting that mitochondrial damage occurred. Intracellular ROS levels increased significantly after knockdown TOMM34 and decreased after over‐expressing TOMM34. The phosphorylation levels of ERK1/2 and MEK1/2 in SCC15 were significantly higher than in Cal27. Besides, the phosphorylation levels of ERK1/2 and MEK1/2 were inhibited in SCC15 after knockdown of TOMM34, but not in Cal27.ConclusionTOMM34 promotes the cell proliferation, migration, and invasion of OSCC. In addition, TOMM34 participates in maintaining the mitochondrial shape and reducing the intracellular ROS level to protect cancer cells. Furthermore, TOMM34 increases the activity of ERK1/2 and MEK1/2 in HPV‐positive OSCC cells but not in HPV‐negative.