bluuebunny/crossref_metadata_2025_split huggingface dataset:
KESULTANAN BUTON PADA MASA PEMERINTAHAN SULTAN ANHARUDDIN: 1823-1824
Authors: H Yuni , Aslim Aslim , Burhan Faika 
Published: April 2022

Tujuan penelitian ini adalah untuk mendeskripsikan profil Sultan Anharuddin yang menjadi Sultan Buton ke-28 pada tahun 1823-1824, untuk mengetahui proses pengangkatan Anharuddin sebagai Sultan Buton pada tahun 1823, serta untuk mengetahui kondisi Kesultanan Buton pada masa pemerintahan Sultan Anharuddin. Metode yang digunakan dalam penelitian ini adalah metode sejarah yang terdiri dari lima tahap kegiatan, yaitu: (a) Pemilihan topik; (b) Heuristik sumber; (c) Verifikasi sumber; (d) Interpretasi, dan (e) Historiografi. Hasil penelitian menunjukkan bahwa Sultan Anharuddin atau La Dani, yang lahir pada tanggal 4 Rajab 1152 Hijriah, merupakan keturunan bangsawan dari golongan Tapi-Tapi. Orang tua Sultan Anharuddin bernama La Masalimu dan ibunya bernama Wa Ode Bawine Putri Kapitalao Itembana Walanda La Ode Ungkuabuso. Sultan Anharuddin menikah dengan Wa Ode Mufti. Anak Sultan Anharuddin dan Wa Ode Mufti adalah Wa Ode Baawu, Wa Ode Moha Raja Tiworo, Wa Ode Ramli Wolowo, Wa Ode Hinusu, Sapati Baadia, dan Wa Ode Aidi Baluna Kapitalao Waale-ale. Proses pengangkatan Anharuddin sebagai Sultan Buton dilakukan setelah Sultan Anharuddin berhasil mengusir Bajak Laut Tobelo. Pemerintahan Sultan Anharuddin sebagai seorang sultan tidak berjalan dengan baik. Hal ini terjadi karena Sultan Anharuddin tidak bersedia menjalankan isi kontrak Dewan Syara Kesultanan Buton dengan pemerintah Belanda sehingga keadaan ekonomi, sosial, dan budaya pada masa pemerintahannya tidak berjalan dengan baik. Kondisi pertahanan dan keamanan Kesultanan Buton pada masa pemerintahan Sultan Anharuddin juga kurang kondusif.
Effect of Occurrence of Lamin A/C (LMNA) Genetic Variants in a Cohort of 101 Consecutive Apparent “Lone AF” Patients: Results and Insights
Authors: Pessente Gabrielle D'Arezzo , Sacilotto Luciana , Calil Zaine Oliveira , Olivetti Natalia Quintella Sangiorgi , Wulkan Fanny , Oliveira Théo Gremen Mimary de , Pedrosa Anísio Alexandre Andrade , Wu Tan Chen , Hachul Denise Tessariol , Scanavacca Maurício Ibrahim , Krieger José Eduardo , Darrieux Francisco Carlos da Costa , Pereira Alexandre da Costa 
Published: April 2022

ObjectiveMutations in the Lamin A/C(LMNA) gene are commonly associated with cardiac manifestations, such as dilated cardiomyopathy (DCM) and conduction system disease. However, the overall spectrum and penetrance of rare LMNA variants are unknown. The present study described the presence of LMNAvariants in patients with “lone atrial fibrillation (AF)” as their sole clinical presentation.MethodsOne-hundred and one consecutive patients with “lone AF” criteria were initially screened by genetic testing. Genetic variants were classified according to the American College of Genetic and Genomic criteria. All subjects were evaluated through clinical and familial history, ECG, 24-h Holter monitoring, echocardiogram, cardiac magnetic resonance, treatment response, and the present relatives of LMNA carriers. In addition, whole-exome data from 49,960 UK Biobank (UKB) participants were analyzed to describe the overall penetrance of rare LMNA missense and loss of function (LOF) variants.ResultsThree missense variants in LMNA were identified in probands with AF as their first and unique clinical manifestation. Other five first-degree relatives, after the screening, also presented LMNA gene variants. Among 49,960 analyzed UKB participants, 331 carried rare LMNA missense or LOF variant. Participants who carried a rare LMNA variant were significantly associated with higher odds of arrhythmic events and of an abnormal ECG in the per-protocol ECG exam (p = 0.03 and p = 0.05, respectively).ConclusionAlthough a rare occurrence, our findings emphasize the possibility of an initial presentation of apparently “lone AF” in LMNA gene variant carriers.
In-vitro and In-silico Haemodynamic Analyses of a Novel Embedded Iliac Branch Device
Authors: Liang Shichao , Jia Heyue , Zhang Xuehuan , Guo Wei , Zhou Guojing , Li Shilong , Yuan Panpan , Xiong Jiang , Chen Duanduan 
Published: April 2022

BackgroundIliac branch devices (IBDs) are valid tools for internal iliac artery preservation during endovascular abdominal aortic aneurysm and iliac aneurysm repair. The purpose of this study was to evaluate the effectiveness of a novel IBD with an embedded branch configuration.MethodA typical iliac artery model was reconstructed, and two models were manufactured using three-dimensional printing technology. The novel IBD was deployed into one iliac artery model by an experienced vascular surgeon. A mock circulation loop (MCL) and a computational fluid dynamics (CFD) simulation were used to investigate the haemodynamic parameters of the iliac models without (Model A) and with (Model B) the IBD. A morphological analysis was conducted using computed tomography angiography and medical endoscopy. The flow distribution rate (FDR) and energy loss (EL) were used to quantify IBD performance.ResultsThe FDR of the right internal iliac artery in the MCL of Model A and Model B was 18.88 ± 0.12% and 16.26 ± 0.09%, respectively (P = 0.0013). The FDR of the right internal iliac artery in the CFD simulation of Model A and Model B was 17.52 and 14.49%, respectively. The EL of Model A was greater than Model B in both the MCL and the CFD simulation. Compared with Model A, Model B had a larger region (8.46 vs. 3.64%) with a relative residence time of &gt;20 Pa−1 at peak systole. Meanwhile, the area where the oscillatory flow index was &gt;0.4 was significantly smaller in Model B than in Model A (0.46 vs. 0.043%). The region with an average wall shear stress of &gt;4 Pa was greater in Model B than in Model A (0 vs. 0.22%).ConclusionThe MCL and CFD simulation showed that the novel IBD had little impact on the FDR and EL of the iliac artery models. However, the IBD might be an effective tool for the treatment of abdominal aortic/iliac aneurysms that extend into branches. Further investigations are warranted to confirm whether this IBD could be useful in the clinic.
Effects of Sacubitril-Valsartan on Clinical, Echocardiographic, and Polygraphic Parameters in Patients Affected by Heart Failure With Reduced Ejection Fraction and Sleep Apnea
Authors: Pelaia Corrado , Armentaro Giuseppe , Volpentesta Mara , Mancuso Luana , Miceli Sofia , Caroleo Benedetto , Perticone Maria , Maio Raffaele , Arturi Franco , Imbalzano Egidio , Andreozzi Francesco , Perticone Francesco , Sesti Giorgio , Sciacqua Angela 
Published: April 2022

BackgroundHeart failure with reduced ejection fraction (HFrEF) is a clinical condition frequently diagnosed in clinical practice. In patients affected by HFrEF, sleep apnea (SA) can be detected among the most frequent comorbidities. Sacubitril–valsartan (sac/val) association has been proven to be effective in reducing disease progression and all-cause mortality in HFrEF patients. Sac/val treatment can potentially attenuate SA development via several pathophysiologic mechanisms, including improvement of global hemodynamics, reduction of extracellular fluid overload, and decrease of sympathetic neural activity.MethodsWe recruited 132 patients affected by HFrEF and SA, already under treatment with continuous positive airway pressure (CPAP), which was discontinued 24 h before the scheduled study timepoints. Physical examination, echocardiography, nocturnal cardio-respiratory monitoring, and laboratory tests were performed in each patient at baseline and after a 6-month treatment with sac/val.ResultsAfter 6 months, sac/val induced statistically significant changes in clinical, hemodynamic, biohumoral (NT-proBNP, serum electrolytes, creatinine, and uric acid), and echocardiographic parameters. In particular, cardiac index (CI), both atrial and ventricular volumes and global longitudinal strain (GLS) improved. Moreover, polysomnography, carried out during a temporary CPAP interruption, revealed a significant reduction in global apnea-hypopnea index (AHI) value (p &lt; 0.0001), central AHI (p &lt; 0.0001), obstructive AHI (p &lt; 0.0001), oxygen desaturation index (ODI) (p &lt; 0.0001), and percentage time of saturation below 90% (TC90) (p &lt; 0.0001). The changes of CI, estimated glomerular filtration rate (eGFR), NT-proBNP, and tricuspid annular plane excursion (TAPSE) contributed to 23.6, 7.6, 7.3, and 4.8% of AHI variability, respectively, and the whole model accounted for a 43.3% of AHI variation.ConclusionsOur results suggest that treatment with sac/val is able to significantly improve the cardiorespiratory performance of patients with HFrEF and SA, integrating the positive impact of CPAP. Thus, both CPAP and sac/val therapy may synergistically contribute to lower the risks of both cardiac and pulmonary complications in HFrEF patients with SA.
Elemental and Isotopic Signatures of Bulk Sedimentary Organic Matter in Shenhu Area, Northern South China Sea
Authors: Li Yuanyuan , Xu Xuemin , Pang Lei , Guan Ping , Fang Yunxin , Lu Hailong , Ye Jianliang , Xie Wenwei 
Published: April 2022

Hydrate-bearing sediments provide excellent materials for studying the primary sources and diagenetic alterations of organic matter. In this study, the elemental and isotopic signatures of total organic carbon (TOC), total inorganic carbon (TIC), total nitrogen (TN), and total sulfur (TS) are systematically investigated in three hydrate-bearing sediment cores (∼240 m) retrieved from the Shenhu area, South China Sea. All sediment layers from three sites are with low TOC content (average 0.35%) with marine and terrestrial mixed sources (-23.6‰ &lt; δ13Corg &lt; -21.4‰). However, the generally low δ15N (2.49–5.31‰) and C/N ratios (4.35–8.2) and their variation with depth cannot be explained by the terrestrial sources (Pearl River) and marine sources, binary end-member mixing processes. Contribution from lateral allochthonous organic matter from the mountainous river is considered after excluding other possible factors and ingeniously elucidating the organic matter origins. Furthermore, specific layers in W01B and W02B exhibit elevated S/C ratios (up to 2.39), positive bias of δ34S-TS (up to +29.7‰), and negative excursion of δ13C-TIC (up to -8.29‰), which are the characteristics of sustained occurrence of sulfate-driven anaerobic oxidation of methane. The occurrence of coupled carbon–sulfur anomaly may be accompanied by deep hydrocarbon leakage and the formation of hydrate with high saturation.
The Value of Dysregulated LncRNAs on Clinicopathology and Survival in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis
Authors: Wang Juan , Han Xu , Yuan Ye , Gu Hao , Liao Xing , Jiang Miao 
Published: April 2022

Background: There is growing evidence that a number of lncRNAs are involved in the pathogenesis of non-small-cell lung cancer (NSCLC). However, studies on lncRNA expression in NSCLC patients are far from conclusive. Therefore, we performed a systematic review of such studies to collect and examine the evidence on the potential role of lncRNAs in the development of NSCLC.Methods: We systematically searched seven literature databases to identify all published studies that evaluated the expression of one or more lncRNAs in human samples with NSCLC (cases) and without NSCLC (controls) from January 1, 1995 to May 24, 2021. Quality assessment of studies was conducted by using the “Quality in Prognosis Studies” (QUIPS) tool, and the heterogeneity across studies was analyzed with the I-squared statistic and chi-square-based Q-tests. Either fixed or random-effect meta-analysis was performed to summarize effect size to investigate the association between lncRNA expression and overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), and clinicopathological features. The R statistical software program was used to conduct standard meta-analysis.Results: We finally obtained 48 studies with 5,211 patients included in this review after screening. Among the 48 lncRNAs, 38 lncRNAs were consistently upregulated, and 10 were deregulated in patients with NSCLC compared with the control groups. The upregulated lncRNAs were positively associated with histological type: study number (n) = 18, odds ratio (OR) = 0.78, 95% CI: 0.65–0.95 and OR = 1.30, 95% CI: 1.08–1.57, p &lt; 0.01; TNM stages: n = 20, OR = 0.41, 95% CI: 0.29–0.57 and OR = 2.44, 95% CI: 1.73–3.44, p &lt; 0.01; lymph node metastasis: n = 29, OR = 0.49, 95% CI: 0.34–0.71 and OR = 2.04, 95% CI: 1.40–2.96, p &lt; 0.01; differentiation grade: n = 6, OR = 0.61, 95% CI: 0.38–0.99 and OR = 1.63, 95% CI: 1.01–2.64, p &lt; 0.01; distant metastasis: n = 9, OR = 0.37, 95% CI: 0.26–0.53 and OR = 2.72, 95% CI: 1.90–3.90, p &lt; 0.01; tumor size: n = 16, OR = 0.52, 95% CI: 0.43–0.64 and OR = 1.92, 95% CI: 1.57–2.34, p &lt; 0.01; and overall survival [n = 38, hazard ratio (HR) = 1.79, 95% CI = 1.59–2.02, p &lt; 0.01]. Especially, five upregulated lncRNAs (linc01234, ZEB1-AS1, linc00152, PVT1, and BANCR) were closely associated with TNM Ⅲa stage (n = 5, OR = 4.07, 95% CI: 2.63–6.28, p &lt; 0.01). However, 10 deregulated lncRNAs were not significantly associated with the pathogenesis and overall survival in NSCLC in the meta-analysis (p ≥ 0.05).Conclusion: This systematic review suggests that the upregulated lncRNAs could serve as biomarkers for predicting promising prognosis of NSCLC. The prognostic value of downregulated lncRNA in NSCLC needs to be further explored.Systematic Review Registration: (http://www.crd.york.ac.uk/PROSPERO).identifier CRD42021240635.
Training in Ultrasound to Determine Gestational Age (TUDA): Evaluation of a Novel Education Package to Teach Ultrasound-Naive Midwives Basic Obstetric Ultrasound in Malawi
Authors: Viner Alexandra C. , Membe-Gadama Gladys , Whyte Sonia , Kayambo Doris , Masamba Martha , Makwakwa Enita , Lissauer David , Stock Sarah J. , Norman Jane E. , Reynolds Rebecca M. , Magowan Brian , Freyne Bridget , Gadama Luis 
Published: April 2022

IntroductionAlthough ultrasound to determine gestational age is fundamental to the optimum management of pregnancy and is recommended for all women by the World Health Organisation, it remains unavailable to many women in low-income countries where trained practitioners are scarce. This study aimed to evaluate a novel, context-specific education package to teach midwives basic obstetric ultrasound, including the determination of gestational age by measurement of fetal femur length.MethodsThe study was conducted across six sites in Malawi in January 2021. Following a virtual “training of the trainers”, local teams delivered a 10-day programme encompassing both didactic and “hands on” components. Matched pre and post course tests assessed participants' knowledge of key concepts, with Objective Structured Clinical Examinations used to evaluate practical skills. To achieve a pass, trainees were required to establish the gestational age to within ±7 days of an experienced practitioner and achieve an overall score of &gt;65% on five consecutive occasions. A matched pre and post course survey explored participants' attitudes and confidence in performing ultrasound examinations.ResultsOf the 29 midwives who participated, 28 finished the programme and met the criteria specified to pass. 22 midwives completed the matched knowledge tests, with the mean (SD) score increasing from 10.2 (3.3) to 18 (2.5) after training (P &lt;0.0001). Mean difference 7.9, 95% CI 6.5–9.2. Midwives passed 87% of the Observed Structured Clinical Examinations, establishing the gestational age to within ±7 days of an experienced practitioner in 89% of assessments. Beliefs regarding the importance of antenatal ultrasound increased post course (p = 0.02), as did confidence in performing ultrasound examinations (p &lt;0.0001).ConclusionThis study demonstrates not only that ultrasound-naive practitioners can be taught to perform basic obstetric ultrasound dating scans, confidently and competently, after 10 days of training, but also that local teams can be orientated to successfully deliver the programme virtually. Previous ultrasound training initiatives, while often more comprehensive in their syllabus, have been of considerably longer duration and this is likely to be a barrier to upscaling opportunities. We propose that this focused training increases the potential for widescale and sustainable implementation.
Comparison of Corneal Optical Quality After SMILE, Wavefront-Optimized LASIK and Topography-Guided LASIK for Myopia and Myopic Astigmatism
Authors: Zhang Yu , Sun Xiaoxiao , Chen Yueguo 
Published: April 2022

PurposeTo compare visual outcomes and corneal optical quality after small incision lenticule extraction (SMILE), wavefront-optimized (WFO) FS-LASIK, and topography-guided customized ablation treatment (TCAT) FS-LASIK for myopia.MethodsThis prospective case-series study included 283 eyes of 283 myopic patients who underwent SMILE or FS-LASIK. There were 102, 100, and 81 eyes in the SMILE group, WFO group and TCAT group, respectively. The tomography system (Sirius) was used to measure corneal aberrations and optical quality.ResultsAt postoperative 1 and 6 months, there were no significant differences in uncorrected distance visual acuity and corrected distance visual acuity among the three groups (P &gt; 0.05). Postoperative manifest refractive spherical equivalent was similar among the groups (P &gt; 0.05). There was statistically significant difference in cylinder at 1 month among the three groups, with the highest mean value in TCAT group (P &lt; 0.05). The corneal optical path difference, root mean square of corneal astigmatism and strehl ratio were the most superior in the TCAT group at postoperative 1 and 6 months (P &lt; 0.05).ConclusionSMILE, WFO FS-LASIK, and TCAT FS-LASIK provided similar visual results. The corneal visual quality after TCAT FS-LASIK was the best.
Identifying Mild Alzheimer's Disease With First 30-Min 11C-PiB PET Scan
Authors: Shen Chushu , Wang Zhenguo , Chen Hongzhao , Bai Yan , Li Xiaochen , Liang Dong , Liu Xin , Zheng Hairong , Wang Meiyun , Yang Yongfeng , Wang Haifeng , Sun Tao 
Published: April 2022

Introduction11C-labeled Pittsburgh compound B (11C-PiB) PET imaging can provide information for the diagnosis of Alzheimer's disease (AD) by quantifying the binding of PiB to β-amyloid deposition in the brain. Quantification index, such as standardized uptake value ratio (SUVR) and distribution volume ratio (DVR), has been exploited to effectively distinguish between healthy and subjects with AD. However, these measures require a long wait/scan time, as well as the selection of an optimal reference region. In this study, we propose an alternate measure named amyloid quantification index (AQI), which can be obtained with the first 30-min scan without the selection of the reference region.Methods11C-labeled Pittsburgh compound B PET scan data were obtained from the public dataset “OASIS-3”. A total of 60 mild subjects with AD and 60 healthy controls were included, with 50 used for training and 10 used for testing in each group. The proposed measure AQI combines information of clearance rate and mid-phase PIB retention in featured brain regions from the first 30-min scan. For each subject in the training set, AQI, SUVR, and DVR were calculated and used for classification by the logistic regression classifier. The receiver operating characteristic (ROC) analysis was performed to evaluate the performance of these measures. Accuracy, sensitivity, and specificity were reported. The Kruskal–Wallis test and effect size were also performed and evaluated for all measures. Then, the performance of three measures was further validated on the testing set using the same method. The correlations between these measures and clinical MMSE and CDR-SOB scores were analyzed.ResultsThe Kruskal–Wallis test suggested that AQI, SUVR, and DVR can all differentiate between the healthy and subjects with mild AD (p &lt; 0.001). For the training set, ROC analysis showed that AQI achieved the best classification performance with an accuracy rate of 0.93, higher than 0.88 for SUVR and 0.89 for DVR. The effect size of AQI, SUVR, and DVR were 2.35, 2.12, and 2.06, respectively, indicating that AQI was the most effective among these measures. For the testing set, all three measures achieved less superior performance, while AQI still performed the best with the highest accuracy of 0.85. Some false-negative cases with below-threshold SUVR and DVR values were correctly identified using AQI. All three measures showed significant and comparable correlations with clinical scores (p &lt; 0.01).ConclusionAmyloid quantification index combines early-phase kinetic information and a certain degree of β-amyloid deposition, and can provide a better differentiating performance using the data from the first 30-min dynamic scan. Moreover, it was shown that clinically indistinguishable AD cases regarding PiB retention potentially can be correctly identified.
Metabolic and Cardiovascular Benefits of Apple and Apple-Derived Products: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Kim Sun Jo , Anh Nguyen Hoang , Jung Cheol Woon , Long Nguyen Phuoc , Park Seongoh , Cho Young Hyun , Yoon Young Cheol , Lee Eun Goo , Kim Mina , Son Eui Young , Kim Tae Ha , Deng Yingqian , Lim Johan , Kwon Sung Won 
Published: April 2022

BackgroundQuantitative evidence of the metabolic and cardiovascular effects of apples (Malus domestica) is lacking in interventional studies. This study aimed to summarize the available evidence of the beneficial effects of apples and apple-derived products (ADPs) on metabolic and cardiovascular markers.MethodsPeer-reviewed randomized controlled trials (RCTs) were identified from four databases on May 3, 2021 and regularly updated until the end of May 2021. Demographic characteristics, intervention types, and evaluation parameters were extracted. A meta-analysis on the mean difference of change scores was conducted on commonly presented outcomes in the RCTs.ResultsThe metabolic and cardiovascular effects of diverse regimens, including whole apple, apple extract, and apple juice, were examined in 18 eligible RCTs. Nine common evaluation outcomes were eventually introduced to the meta-analysis, including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, glucose, insulin, C-reactive protein, and systolic/diastolic blood pressures. The levels of TC (−2.69 mg/dL; 95% CI: −5.43, 0.04 mg/dL) and LDL (−2.80 mg/dL; 95% CI: −5.78, 0.17 mg/dL) showed a non-significant decreasing tendency after at least a week of apple consumption. Further subgroup analysis, particularly, a comparison with placebo as a control, showed a significant reduction in TC and LDL levels. When stratified by the baseline level, subjects with high TC and LDL level were shown to have more benefits from the apple intake. Intriguingly, apple and ADPs significantly reduced HDL levels to a small extent (−1.04 mg/dL; 95% CI: −1.79, −0.29 mg/dL). The other markers were mostly unaffected by the intervention.ConclusionOur investigation revealed that apples could improve blood cholesterol levels.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42020215977].