bluuebunny/crossref_metadata_2025_split huggingface dataset:
Art Therapy in Burn Cases
Authors: Malhotra Bani , Anand Susan A. , Kaimal Girija 
Published: March 2022

Abstract
In this article, we provide an overview of the literature on contributions of art making and medical art therapy for patients with burn injuries. The potential value of art therapy in addressing the complex physical and psychosocial needs of burn patients is discussed through examination of 7 peer-reviewed articles. Two case examples of burn survivors, 1 pediatric and 1 adult, are included to demonstrate the use of art therapy in an inpatient and outpatient setting, respectively. Art therapy and other intervention strategies for overall psychosocial adjustment of burn patients are often underutilized. Further research in art therapy is needed to examine the psychosocial aspects of burns patients and the potential role that medical art therapy may have in a burn care center.
Labile sex expression in angiosperm species with sex chromosomes
Authors: Käfer Jos , Méndez Marcos , Mousset Sylvain 
Published: March 2022

Here, we review the literature on sexual lability in dioecious angiosperm species with well-studied sex chromosomes. We distinguish three types of departures from strict dioecy, concerning either a minority of flowers in some individuals (leakiness) or the entire individual, which can constantly be bisexual or change sex. We found that for only four of the 22 species studied, reports of lability are lacking. The occurrence of lability is only weakly related to sex chromosome characteristics (number of sex-linked genes, age of the non-recombining region). These results contradict the naive idea that lability is an indication of the absence or the recent evolution of sex chromosomes, and thereby contribute to a growing consensus that sex chromosomes do not necessarily fix sex determination once and for all. We discuss some implications of these findings for the evolution of sex chromosomes, and suggest that more species with well-characterized lability should be studied with genomic data and tools.This article is part of the theme issue ‘Sex determination and sex chromosome evolution in land plants’.
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike
Authors: Wnuk Kamil , Sudol Jeremi , Spilman Patricia , Soon-Shiong Patrick 
Published: March 2022

AbstractTo provide a unique global view of the relative potential for evasion of CD8+ and CD4+ T cells by SARS-CoV-2 lineages as they evolve over time, we performed a comprehensive analysis of predicted HLA-I and HLA-II binding peptides in spike (S) and nucleocapsid (N) protein sequences of all available SARS-CoV-2 genomes as provided by NIH NCBI at a bi-monthly interval between March and December of 2021. A data supplement of all B.1.1.529 (Omicron) genomes from GISAID in early December was also used to capture the rapidly spreading variant. A key finding is that throughout continued viral evolution and increasing rates of mutations occurring at T-cell epitope hotspots, protein instances with worst case binding loss did not become the most frequent for any Variant of Concern (VOC) or Variant of Interest (VOI) lineage; suggesting T-cell evasion is not likely to be a dominant evolutionary pressure on SARS-CoV-2. We also determined that throughout the course of the pandemic in 2021, there remained a relatively steady ratio of viral variants that exhibit conservation of epitopes in the N protein, despite significant potential for epitope loss in S relative to other lineages. We further localized conserved regions in N with high epitope yield potential, and illustrated HLA-I binding heterogeneity across the S protein consistent with empirical observations. Although Omicron’s high volume of mutations caused it to exhibit more epitope loss potential than most frequently observed versions of proteins in almost all other VOCs, epitope candidates across its most frequent N proteins were still largely conserved. This analysis adds to the body of evidence suggesting that N may have merit as an additional antigen to elicit immune responses to vaccination with increased potential to provide sustained protection against COVID-19 disease in the face of emerging variants.
Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2
Authors: Anglero-Rodriguez Yesseinia I. , Lempp Florian A. , McIninch James , Schlegel Mark K. , Brown Christopher R. , Foster Donald J. , Castoreno Adam B. , Nguyen Tuyen , Subramanian Megha , Montiel-Ruiz Martin , Kaiser Hannah , Sahakyan Anna , Spreafico Roberto , Morskaya Svetlana Shulga , Barry Joseph D. , Berman Daniel , Lefebvre Stephanie , Kasper Anne , Racie Timothy , Weddle Diann , Mobley Melissa , Rogers Arlin , Dybowski Joseph , Chong Saeho , Nair Jayaprakash , Simon Amy , Sloan Kevin , Hwang Seungmin , Virgin Herbert W. , Fitzgerald Kevin , Maier Martin A. , Hinkle Gregory , Hebner Christy M. , Akinc Akin , Jadhav Vasant 
Published: March 2022

AbstractRNA interference is a natural antiviral mechanism that could be harnessed to combat SARS-CoV-2 infection by targeting and destroying the viral genome. We screened lipophilic small-interfering RNA (siRNA) conjugates targeting highly conserved regions of the SARS-CoV-2 genome and identified leads targeting outside of the spike-encoding region capable of achieving ≥3-log viral reduction. Serial passaging studies demonstrated that a two-siRNA combination prevented development of resistance compared to a single-siRNA approach. A two-siRNA combination delivered intranasally protected Syrian hamsters from weight loss and lung pathology by viral infection upon prophylactic administration but not following onset of infection. Together, the data support potential utility of RNAi as a prophylactic approach to limit SARS-CoV-2 infection that may help combat emergent variants, complement existing interventions, or protect populations where vaccines are less effective. Most importantly, this strategy has implications for developing medicines that may be valuable in protecting against future coronavirus pandemics.
Mapping the Neural Dynamics of Locomotion across the Drosophila Brain
Authors: Brezovec Luke E. , Berger Andrew B. , Druckmann Shaul , Clandinin Thomas R. 
Published: March 2022

SummaryWalking is a fundamental mode of locomotion, yet its neural correlates are unknown at brain-wide scale in any animal. We use volumetric two-photon imaging to map neural activity associated with walking across the entire brain of Drosophila. We detect locomotor signals in approximately 40% of the brain, identify a global signal associated with the transition from rest to walking, and define clustered neural signals selectively associated with changes in forward or angular velocity. These networks span functionally diverse brain regions, and include regions that have not been previously linked to locomotion. We also identify time-varying trajectories of neural activity that anticipate future movements, and that represent sequential engagement of clusters of neurons with different behavioral selectivity. These motor maps suggest a dynamical systems framework for constructing walking maneuvers reminiscent of models of forelimb reaching in primates and set a foundation for understanding how local circuits interact across large-scale networks.
Plant Virus Database: a resource for exploring the diversity of plant viruses and their interactions with hosts
Authors: Wu Han , Fu Ping , Fu Qiong , Zhang Zheng , Zheng Heping , Mao Longfei , Li Xiaoxu , Yu Feng , Peng Yousong 
Published: March 2022

AbstractPlant viruses cause huge damage to commercial crops, yet the studies towards plant viruses are limited and the diversity of plant viruses are under-estimated yet. This study built an up-to-date atlas of plant viruses by computationally identifying viruses from the RNA-seq data in the One Thousand Plant Transcriptomes Initiative (1KP) and by integrating plant viruses from public databases, and further built the Plant Virus Database (PVD, freely available at http://47.90.94.155/PlantVirusBase/#/home) to store and organize these viruses. The PVD contained 3,206 virus species and 9,604 virus-plant host interactions which were more than twice that reported in previous plant virus databases. The plant viruses were observed to infect only a few plant hosts and vice versa. Analysis and comparison of the viromes in the Monocots and Eudicots, and those in the plants in tropical and temperate regions showed significant differences in the virome composition. Finally, several factors including the viral group (DNA and RNA viruses), enveloped or not, and the transmission mode of viruses, were found to have no or weak associations with the host range of plant viruses. Overall, the study not only provides a valuable resource for further studies of plant viruses, but also deepens our understanding towards the genetic diversity of plant viruses and the virus-host interactions.
A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells
Authors: Obashi Kazuki , Sochacki Kem A. , Strub Marie-Paule , Taraska Justin W. 
Published: March 2022

AbstractThe conformations of endocytic proteins and their interactions are key regulators of clathrin-mediated endocytosis. Three clathrin light chains (CLC), along with three clathrin heavy chains, assemble to form single clathrin triskelia that link into a geometric lattice that curves to drive endocytosis. Conformational changes in CLC have been shown to regulate triskelia assembly in solution, yet the nature of these structural changes, and their effects on lattice growth, curvature, and endocytosis in cells are unclear. Here, we develop a correlative fluorescence resonance energy transfer (FRET) and platinum replica electron microscopy method, named FRET-CLEM. With FRET-CLEM, we measure conformational changes in proteins at thousands of individual morphologically distinct clathrin-coated structures across cell membranes. We find that the N-terminus of CLC moves away from the plasma membrane and triskelia vertex as lattices curve. Preventing this conformational switch with acute chemical tools inside cells increased clathrin structure sizes and inhibited endocytosis. Therefore, a specific conformational switch in CLC regulates lattice curvature and endocytosis in mammalian cells.
Thousands of examining eyes: credibility, authority and validity in biodiversity citizen science data production
Authors: Ekström Björn 
Published: March 2022

PurposeThe purpose of this study is to contribute with knowledge about how valid research data in biodiversity citizen science are produced through information practices and how notions of credibility and authority emerge from these practices.Design/methodology/approachData were collected through an empirical, interview-based study of the information practices of 15 participants active in the vicinity of the Swedish biodiversity citizen science information system Artportalen. Interview transcripts were analysed abductively and qualitatively through a coding scheme by working back and forth between theory and data. Values of credibility, authority and validity of research data were unfolded through a practice-oriented perspective to library and information studies by utilising the theoretical lens of boundary objects.FindingsNotions of credibility, authority and validity emerge through participant activities of transforming species observations to data, supplementing reports with objects of trust, augmenting identification through authority outreach and assessing credibility via peer monitoring. Credibility, authority and validity of research data are shown to be co-constructed in a distributed fashion by the participants and the information system.Originality/valueThe article extends knowledge about information practices in emerging, heterogeneous scholarly settings by focussing on the complex co-construction of credibility, authority and validity in relation to data production.
TRIVIA’s social media effectiveness
Authors: Arora Soma 
Published: March 2022

Learning outcomes
Besides the metrics developed to measure the impact of the video campaign run by the company, the case has serious practical implications for all companies in emerging markets selling budget/low-cost products. Marketing managers can take note of these key performance indicators in evaluating the success of their social media campaigns.More importantly, students need to understand how the campaign managed to integrate uninitiated and less-privileged consumers to the world of social media with aspirational sentiments.

Case overview/synopsis
The case deals with a digital media planning activity for a low-cost handset company based in India. TRIVIA International Ltd is a manufacturer and marketer of smart phones and feature phone in the price range of below US$70–100 and US$20, respectively. The phones cater to low-income consumer bracket, which forms the vast microcosm of India. The consumer base is huge, but the purchasing power is very low, so they are at times referred to as the micro-consumer in Bottom of Pyramid approach. To approach this consumer base, Trivia planned a very engaging campaign on social media that yielded positive results, contrary to popular belief that only high-income individuals explore the social media intensively through their smart phones. The chapter ends with a set of recommendations for all digital managers who want to analyse their campaigns effectively via awareness, sentiment and engagement metrics.

Complexity academic level
The case is meant for all post graduate programs in Business Management, which include the MBAs, Masters in Business Administration and the Executive Development program for managers. The case can also be used in Part Time Business Management programs held over weekends for working professionals. Most likely the students are going to handle this case in their second year of a full-time program or at an advanced level of their career development programs. The subjects so mentioned here were offered as electives or areas of specialization. It is presumed that the students undergoing these courses have basic understanding of marketing management.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 8: Marketing.
Collaboration scope and product innovation in B2B markets: are there too many cooks or is it the customer who spoils the broth?
Authors: Mooi Erik , Osinga Ernst Christiaan , Santos Carlos Daniel 
Published: March 2022

Purpose
Product innovations are often the result of combinations of internal and external knowledge. A significant amount of open innovation literature has argued that working with external partners can be beneficial, in particular, when this is complemented by internal R&D, yet a wholesale shift to open innovation has not occurred. The purpose of this study is to demonstrate two new limits of openness, grounded in attention-based theory, that help explain why such a shift has not occurred. This study argues that specific combinations of identities a firm collaborates with, that is, whether a partner is classified as a customer, supplier, competitor or university and/or technological center, predictably increase and decrease product innovation.

Design/methodology/approach
This study demonstrates these findings using econometric techniques on a large-scale panel data set, comprising 14,682 observations.

Findings
The authors observe positive effects of customer collaboration, partner scope (collaboration with other outside identities) and internal R&D when considered separately. Critically, they observe two important situations where these positive effects are reduced. First, they argue and observe that when customers are added to the mix of identities, diminished returns on product innovation result. Second, they argue and observe that technological customer collaboration reduces the benefits from an internal R&D department (more than collaboration with other identities). The findings of this study are robust in that singling out another partner identity does not reveal such patterns.

Research limitations/implications
The findings stress the importance of considering the identity of collaborating parties in studying the impact of openness on innovation success. This study conceptually and empirically rejects the – implicitly held – assumption in the literature that different partners provide similar benefits and are interchangeable.

Practical implications
This study proposes new limits to the “open innovation” literature. As identities are easy to observe by managers and are shown to impact product innovation, this study argues they are highly relevant to managerial decision-making. This study also observes, through counterfactual analysis, that attention limits are critical, as a theoretical setting of no attention limits would significantly lift product innovations.

Originality/value
This study shows important limitations to the open innovation literature by showing that customer collaboration leads to declining rates of product innovation when combined with greater collaboration scope or the internal R&D department. This study adds the novel insight that customer collaboration weakens the positive effect of collaboration scope and internal R&D on product innovations.
The determinants of an information security policy compliance culture in organisations: the combined effects of organisational and behavioural factors
Authors: Amankwa Eric , Loock Marianne , Kritzinger Elmarie 
Published: March 2022

Purpose
This paper aims to examine the individual and combined effects of organisational and behavioural factors on employees’ attitudes and intentions to establish an information security policy compliance culture (ISPCC) in organisations.

Design/methodology/approach
Based on factors derived from the organisational culture theory, social bond theory and accountability theory, a testable research model was developed and evaluated in an online survey that involves the use of a questionnaire to collect quantitative data from 313 employees, from ten different organisations in Ghana. The data collected were analysed using the partial least squares-structural equation modelling approach, involving the measurement and structural model tests.

Findings
The study reveals that the individual measures of accountability – identifiability (2.4%), expectations of evaluation (38.8%), awareness of monitoring (55.7%) and social presence (−41.2%) – had weak to moderate effects on employees’ attitudes towards information security policy compliance. However, the combined effect showed a significant influence. In addition, organisational factors – supportive organisational culture (15%), security compliance leadership (2%) and user involvement (63%) – showed positive effects on employees’ attitudes. Further, employees’ attitudes had a substantial influence (65%), while behavioural intentions demonstrated a weak effect (24%) on the establishment of an ISPCC in the organisation. The combined effect also had a substantial statistical influence on the establishment of an ISPCC in the organisation.

Practical implications
Given the findings of the study, information security practitioners should implement organisational and behavioural factors that will have an impact on compliance, in tandem, with the organisational effort to build a culture of compliance for information security policies.

Originality/value
The study provides new insights on how to address the problem of non-compliance with regard to the information security policy in organisations through the combined application of organisational and behavioural factors to establish an information security policy compliance culture, which has not been considered in any past research.
Does foreign direct investment stimulate the output growth of the formal economic sector in Vietnam: a subnational-level analysis
Authors: Dao Thi Bich Thuy , Ngo Vi Dung 
Published: March 2022

PurposeThis study focuses on the relationship between foreign direct investment (FDI) and economic growth of the formal sector comprising all foreign and domestic registered enterprises engaged in production of goods and services.Design/methodology/approachThis study uses a balanced longitudinal data set for the period from 2006 to 2014 from secondary sources in 63 provinces/cities of Vietnam. The generalized method of moments (GMM) estimation for a dynamic panel data model is applied.FindingsThe greater the share of FDI in capital resource, the more favorable the output growth in the whole formal sector. The FDI enterprises are more productive than domestic formal firms, and the output growth of FDI firms creates a positive spillover effect on the output growth of domestic firms.Originality/valueThe effect of FDI on economic growth is investigated at subnational level for the whole formal economic sector as well as the formal domestic firms. The domestic and foreign industrial agglomerations and the business environment are also examined.
Comovements and spillovers in international commercial and residential real estate markets
Authors: Kishor N. Kundan 
Published: March 2022

PurposeThis study aims to know to what extent do the commercial and residential estate markets move together in different economies? Do the shocks originating in one of these markets spillover to the other markets?Design/methodology/approachThe authors apply a modified version of the dynamic factor model to commercial and residential real estate prices in the Euro area, Hong Kong, Singapore and the USA. This modified dynamic factor model decomposes price growth in these two real estate markets into common, spillover and idiosyncratic components.FindingsThe results show significant heterogeneity in the relative importance of different components in the evolution of commercial and residential price growth across different economies. The findings suggest that the spillover from the residential to commercial real estate market dominates the spillover from the commercial to real estate market for all the economies in our sample. The authors also find that the common component accounts for a large fraction of the price movements in the residential markets in the European Union (EU) area and the USA, whereas spillover and common components together explain more than two-thirds of the variations in Hong Kong and Singapore. The results suggest that the role of spillover from one market to another increased significantly during the financial crisis of 2008–2009.Originality/valueThis paper contributes to the existing literature on how the transmission of shocks takes place across commercial and residential real estate markets. The transmission of shocks can take place in two directions in the proposed framework. There may be a direct spillover from a shock from one market to another. This corresponds to a shock to the idiosyncratic component affecting the other idiosyncratic component. In this paper, the authors are mainly interested in indirect spillover where the shock would transmit from the idiosyncratic factor to the common factor, and then from the common factor to the other idiosyncratic factor.