bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competing logics in budgeting in a university setting in Tanzania
Authors: Mkasiwa Tausi 
Published: August 2022

Purpose
This study aims to investigate how actors’ responses to competing logics (academic and business logics) in budgetary practices in a university setting in Tanzania were shaped by state pressure, market pressure and organizational characteristics (funding certainty and changes in university ownership) and how actors’ agency was exercised in enacting competing logics.

Design/methodology/approach
The data for this study were collected from interviews, observations, informal discussions and document review. The data analysis processes were guided by institutional logic concepts and the role of actors’ agency.

Findings
The findings demonstrate how academic logic traditionally subsisted in a university setting in which there was funding certainty. Changes in the university’s ownership resulted in funding uncertainty. Market and state pressure increased the intensity of funding uncertainty, which supported business logic. While market logic supported the emergence of business logic, state pressure altered the balance of the competing logics. University actors responded by selective coupling and compartmentalizing where both elements of academic and business logics were enacted. While managers prioritized business logic, academics prioritized academic logic. However, the role of agency was exercised in actors’ responses, subverting both academic and business logics.

Practical implications
Managers should appropriately enact both elements of competing logics to avoid marginalization of some of the core university activities. In addition, profitable business ideas should be considered, identified, planned and implemented successfully. Moreover, there is a need to change the historically contingent and culturally situated environment when enacting competing logics. Furthermore, the state influence on universities should be considered to prevent unnecessary uncertainties in budgetary practices.

Originality/value
The paper demonstrates how selective coupling and compartmentalizing strategies were used by actors to enact both elements of competing logics in budgetary practices in a university setting. It further shows how actors’ agency influenced and subverted competing logics. The paper, thus, responds to the recent calls to investigate the influence of institutional logics on control practices, and the role of actors in strategically handling different logics in developing countries (Damayanthi and Gooneratne, 2017; Argento et al., 2020; Anessi-Pessina et al., 2016; Grossi et al., 2020). It further suggests new analysis of academic and business logics in their context.
Personality trait imprints across generations: small family business context
Authors: Ahmad Zeshan , Sharif Shahbaz , Alrashid Muhammad Ahmad , Nadeem Muhammad 
Published: August 2022

PurposeThe purpose of this study is to investigate how the congruence between predecessor and successor personality traits (PTs) with the values of their small family business (SFB) contributes to a successful succession transition across generations.Design/methodology/approachThe conceptual model method was employed in this investigation, which describes an entity and identifies issues that should be considered in a study (MacInnis, 2011). It involves a form of theorizing that seeks to create a nomological network around the focal concept, to examine and detail the causal linkages and mechanisms at play (Delbridge and Fiss, 2013).FindingsDrawing on the trait activation theory (TAT), this study conceptualizes that the congruence of the successor's PTs with those of the predecessor, as well as the values, transitions and nature of the assigned task, activates the successor's PTs and motivates him to work diligently for a successful succession transition while preserving the business's core values established by the founder.Research limitations/implicationsThis study is an eye-opener for strategists and SFB predecessors to ponder the successor's PTs disparities across generations. Additionally, it urges them to consider the congruence of SFB's values and nature of operations with the successor's PTs for successful succession transition. Thus, such awareness may contribute to stabilizing the SFB's survival rate.Originality/valueThis study contributed to the existing literature by answering how predecessor’s and successor's PTs congruence and SFB's values and nature of operations congruence with their PTs may contribute to successful succession transition across generations. This study contributed to the TAT by thematically explaining the organizational cues to bridge a relationship between entrepreneurial personality traits (EPT) and succession success of SFBs.
Patient's preference for sacrospinous hysteropexy or modified Manchester operation: A discrete choice experiment
Authors: Schulten Sascha F. M. , Essers Brigitte , Notten Kim J. B. , Enklaar Rosa A. , van Leijsen Sanne A. L. , van Eijndhoven Hugo W. F. , Kluivers Kirsten B. , Weemhoff Mirjam 
Published: August 2022

AbstractObjectiveTo investigate women's preference for modified Manchester (MM) or sacrospinous hysteropexy (SH) as surgery for uterine prolapse.DesignLabelled discrete choice experiment (DCE).SettingEight Dutch hospitals.PopulationWomen with uterine prolapse, eligible for primary surgery and preference for uterus preservation.MethodsDCEs are attribute‐based surveys. The two treatment options were labelled as MM and SH. Attributes in this survey were treatment success ( levels SH: 84%, 89%, 94%; levels MM: 89%, 93%, 96%), dyspareunia (levels: 0%, 5%, 10%), cervical stenosis (levels: 1%, 6%, 11%) and severe buttock pain (levels: 0%, 1%). A different combination of attribute levels was used in each choice set. Women completed nine choice sets, making a choice based on attribute levels. Data were analysed in multinomial logit models.Main outcome measuresWomen's preference for MM or SH.Results137 DCEs were completed (1233 choice sets). SH was chosen in 49% of the choice sets, MM in 51%. Of all women, 39 (28%) always chose the same surgery. After exclusion of this group, 882 choice sets were analysed, in which women preferred MM, likely associated with a labelling effect, i.e. description of the procedure, rather than the tested attributes. In that group, MM was chosen in 53% of the choice sets and SH in 47%. When choosing MM, next to the label, dyspareunia was relevant for decision‐making. For SH, all attributes were relevant for decision‐making.ConclusionsThe preference of women for MM or SH seems almost equally divided. The variety in preference supports the importance of individualised healthcare.
Effects of chronic cocaine and ethanol self‐administration on brain dopamine receptors in a rhesus monkey model of polysubstance abuse
Authors: Say Felicity M. , Tryhus Aaron M. , Epperly Phillip M. , Nader Susan H. , Solingapuram Sai Kiran K. , George Brianna E. , Kirse Haley A. , Czoty Paul W. 
Published: August 2022

AbstractMost individuals with cocaine use disorder also use alcohol; however, little is known about the behavioural and pharmacological mechanisms that promote co‐abuse. For example, although studies in humans and animals have documented that chronic use of either alcohol or cocaine alone decreases D2‐like receptor (D2R) availability, effects of co‐abuse of these substances on dopamine receptor function have not been characterized. These studies examined the effects of long‐term cocaine self‐administration in 12 male rhesus monkeys who also consumed either ethanol or an ethanol‐free solution each day (n = 6 per group). Specifically, all monkeys self‐administered cocaine (0.1 mg/kg per injection) 5 days per week in the morning. In the afternoon, six monkeys consumed 2.0 g/kg ethanol over 1 h to model binge drinking and six monkeys drank an ethanol‐free solution. Assessment of D2R availability using positron emission tomography (PET) and [11C]raclopride occurred when monkeys were drug‐naïve and again when monkeys had self‐administered approximately 400‐mg/kg cocaine. D3R function was assessed at the same time points by determining the potency of the D3R‐preferring agonist quinpirole to elicit yawns. Chronic cocaine self‐administration decreased D2R availability in subregions of the basal ganglia in control monkeys, but not those that also drank ethanol. In contrast, D3R sensitivity increased significantly after chronic cocaine self‐administration in ethanol‐drinking monkeys but not controls. These results suggest that co‐use of ethanol substantially changes the effects of chronic cocaine self‐administration on dopamine receptors, specifically implicating D3R as a target for medications in these individuals.
Sodium acamprosate and calcium exert additive effects on nucleus accumbens dopamine in the rat
Authors: Ademar Karin , Adermark Louise , Söderpalm Bo , Ericson Mia 
Published: August 2022

AbstractAcamprosate (Campral® – calcium‐bis[N‐acetylhomotaurinate]) is one of few available pharmacotherapies for individuals suffering from alcohol use disorder. Previously, we suggested that acamprosate reduces ethanol intake by increasing dopamine in the nucleus accumbens (nAc), thereby partly substituting for alcohol's dopamine releasing effect. An experimental study suggested the calcium moiety of acamprosate to be the active component of the drug and to mediate the relapse preventing effect. The aim of the present study was to, by means of reversed in vivo microdialysis, elucidate if the dopamine elevating properties of acamprosate are mediated by N‐acetylhomotaurine or by the calcium moiety. Male rats were equipped with a microdialysis probe in the nAc and received acute local treatment with regular acamprosate (CaAcamp 0.5 mM), calcium chloride (CaCl2 0.5 mM), sodium acamprosate (NaAcamp 0.5–1 mM), the glycine receptor (GlyR) antagonist strychnine (Stry 20 μM), or vehicle. In all experiments, extracellular levels of dopamine and taurine were examined. We found that local perfusion with both CaAcamp and CaCl2 increased dopamine levels in a GlyR‐dependent manner. NaAcamp did not influence dopamine levels, but concomitant administration with CaCl2 resulted in an additive dopamine output compared to the drugs administrated alone. We also found CaAcamp and the combination of CaCl2 and NaAcamp to increase accumbal taurine levels, suggesting that CaAcamp may act indirectly on GlyRs via taurine release. The present results indicate that both N‐acetylhomotaurine and the calcium moiety of acamprosate have dopamine elevating properties within the nAc and that, in this respect, these substances are beneficial in combination.
Effects of traditional and novel proteolytic agents on tissue dissolution and dentine microhardness
Authors: Jacob Shwetha Elizabeth , Prasad Niharika , Dutta Sreya , Kumblekar Vasavi , Natarajan Srikant , Jayaprakash Kukkila , Thomas Manuel Sebastian 
Published: August 2022

AbstractThe study aimed to evaluate the tissue‐dissolving ability of papain and bromelain with respect to that of sodium hypochlorite (NaOCl) at the temperatures of 25°C and 60°C. The study also assessed the effects of these proteolytic agents on radicular dentine microhardness. Warming NaOCl, papain and bromelain solutions resulted in significant tissue dissolution at all time intervals (p < 0.001). At 60°C, bromelain showed significantly higher tissue weight loss at every time interval when compared to NaOCl (p < 0.001). All of the three organic tissue dissolvents reduced the microhardness at 1 hr when compared to their respective baseline values. The reduction in microhardness from the baseline reading was statistically significant only in the papain group at 30 min (p = 0.018) and at 60 min (p = 0.03) when compared to the control group. Hence it was concluded that bromelain exerted superior tissue dissolution action, especially when warmed, with minimal effect on dentine microhardness.
Molecular basis and targeted therapies for radioiodine refractory thyroid cancer
Authors: Yu Qiuxiao , Zhang Xuwen , Li Li , Zhang Chi , Huang Jian , Huang Wenting 
Published: August 2022

AbstractPatients diagnosed with radioiodine refractory thyroid cancer (RAIR‐TC) are not amenable to novel 131I therapy due to the reduced expression of sodium iodide symporter (Na+/I‐ symporter, NIS) and/or the impairment of NIS trafficking to the plasma membrane. RAIR‐TC patients have a relatively poor prognosis with a mean life expectancy of 3–5 years, contributing to the majority of TC‐associated mortality. Identifying RAIR‐TC patients and selecting proper treatment strategies remain challenging for clinicians. In this review, we demonstrate the updated clinical scenarios or the so‐called “definitions” of RAIR‐TC suggested by several associations based on 131I uptake ability and tumor response post‐131I therapy. We also discuss current knowledge of the molecular alterations involved in membrane‐localized NIS loss, which provides a preclinical basis for the development of targeted therapies, in particular, tyrosine kinase inhibitors (TKIs), redifferentiation approaches, and immune checkpoint inhibitors.
Malignant pericardial effusions: A retrospective look at etiology and prognosis in a tertiary oncological center
Authors: Quirk Thomas , Yao Yao , Sverdlov Aaron , Murch Stuart 
Published: August 2022

AbstractPurposeCancer and the associated treatments are important causes of pericardial effusion. However, the natural history of malignant pericardial effusion is largely unknown, especially in the context of newer cancer treatments. We investigated the causes of pericardial effusions in a tertiary oncology center, with particular focus on the prognosis of malignant effusions in the era of contemporary oncological therapies.MethodWe obtained data from electronic medical records. Survival analyses were performed utilizing the Kaplan–Meier method. We performed Cox regression to explore the potential clinical factors associated with survival.ResultsForty‐four patients had pericardial effusion treated with pericardiocentesis during the study period. The mean age was 62‐years, and 55% were female. Sixty‐eight percent of these patients also had cancer, with approximately half (47%) receiving prior chemotherapy, and a quarter (27%) having had chest radiotherapy. Seventy percent of the patients with active cancer had malignant cells on cytology of pericardial fluid. The median survival of the cohort was 227 days, with malignant effusions having a median survival of 62‐days compared to nonmalignant effusions with 1408 days (Logrank statistic 7.4, p‐value .007). Malignant cytology was significantly associated with mortality on univariable analysis (HR 2.5, 95% CI 1.2–5.3). Complication rates were low, with no deaths as a direct complication of pericardiocentesis.ConclusionMalignancy is the most common cause of pericardial effusion in this tertiary medical and oncological center. Abnormal cytology with malignant cells has a poor median survival, despite advances in oncological treatment over the last decade. Pericardiocentesis is a safe procedure for these patients.
Decoding Australia's China threat narrative during 2016–2021
Authors: Liu Kerry 
Published: August 2022

AbstractAustralia–China relations began to sour in 2016, and the China threat narrative began to dominate since then. Unlike previous studies which either use a qualitative approach or cross‐sectional dataset for empirical analysis, this study creatively creates high‐frequency weekly and monthly time series datasets using the Google Trends search results during January 2016–February 2021. Based on a series of time series modellings, this study examines the roles of various actors, including China's own policies, the Australian Strategic Policy Institute and Clive Hamilton, various factors, including Chinese purchase of Australian housing, Chinese investment in Australia, Chinese students in Australia and China's rise and various media outlets, including the Australian Broadcasting Corporation, Australian Financial Review, Sydney Morning Herald, Daily Telegraph and Herald Sun, in contributing to Australia's China threat narrative. This study makes significant contributions to academia in methods by bringing a new quantitative approach to international relations studies and to policy‐makers as well by quantifying the roles of various actors, factors and media outlets in Australia's China policy debate.
A case of intestinal malrotation apparent after laparoscopically total proctocolectomy followed by ileal‐pouch‐anal anastomosis for ulcerative colitis
Authors: Ichikawa Hidetaka , Ohnuma Shinobu , Imoto Hirofumi , Kageyama Sakiko , Kobayashi Minoru , Kajiwara Taiki , Karasawa Hideaki , Kohyama Atsushi , Watanabe Kazuhiro , Tanaka Naoki , Kamei Takashi , Unno Michiaki 
Published: August 2022

AbstractIntestinal malrotation (IM) is an abnormality due to a failure of the normal midgut rotation and fixation. We report a case of 46‐year‐old man with ulcerative colitis whose IM was apparent after laparoscopically total proctocolectomy (TPC) followed by ileal‐pouch‐anal anastomosis (IPAA) and ileostomy. There was no abnormal anatomy except for mobile cecum/ascending colon during the initial operation. Intestinal obstruction occurred after ileostomy closure. The computed tomography scan showed the duodeno‐jejunal transition was located in right abdomen, the superior mesenteric vein was located left of the superior mesenteric artery (SMA) and the obstruction point was the distal ileum near the pouch. We performed an ileo‐ileo bypass across the ventral side of the SMA to relieve the intestinal obstruction. The patient would have incomplete IM preoperatively, which became apparent by TPC. In case of TPC for mobile colon, anatomy of small intestine should be checked before IPAA.
A population pharmacokinetic model based on HPTN 077 of long‐acting injectable cabotegravir for HIV PrEP
Authors: Yu Yifan , Bigos Kristin L. , Marzinke Mark A. , Landovitz Raphael J. , McCauley Marybeth , Ford Susan , Hendrix Craig W. , Bies Robert R. , Weld Ethel D. ,   the HPTN 077 Study Team
Published: August 2022

AimsCabotegravir delivered as a long‐acting intramuscular injection has shown superior efficacy to oral tenofovir‐emtricitabine as pre‐exposure prophylaxis (PrEP) for HIV. Cabotegravir pharmacokinetics (PK), like those of other long‐acting depot preparations, exhibit variability between individuals and between injection occasions. The aim of this study is to describe the population pharmacokinetics of long‐acting cabotegravir (CAB‐LA).MethodsUsing available PK measurements from 133 participants in the HIV Prevention Trials Network (HPTN) 077 trial, we analysed CAB‐LA PK data using nonlinear mixed‐effects modelling to develop a population PK model.ResultsA two‐compartment model with first order absorption best described the CAB‐LA PK. The analysis identified between‐occasion variability (BOV, i.e., differences in PK within one individual from one injection to the next) as a significant covariate affecting the absorption rate, with an estimated contribution of BOV to PK variability on the absorption rate (ka) of 38.5%. Sex and body weight were identified as significant covariates influencing the absorption rate and apparent clearance of CAB‐LA after intramuscular injection at various doses and frequencies. Male participants had 67% higher ka than female participants. Serially adding to the model body weight on clearance, sex on ka, and BOV on ka led to a decrease in the objective function value (OFV) of 24.4, 36 and 321.4, respectively.ConclusionThe public availability of this model will facilitate and enable a wide variety of future clinically relevant simulations to inform the optimal use of CAB‐LA.
Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer
Authors: Sakashita Takuya , Yanagitani Noriko , Koike Sumie , Low Siew‐Kee , Takagi Satoshi , Baba Satoko , Takeuchi Kengo , Nishio Makoto , Fujita Naoya , Katayama Ryohei 
Published: August 2022

AbstractThe rearrangement of anaplastic lymphoma kinase (ALK) occurs in 3%‐5% of patients with non–small cell lung cancer (NSCLC) and confers sensitivity to ALK–tyrosine kinase inhibitors (TKIs). For the treatment of patients with ALK‐rearranged NSCLC, various additional ALK‐TKIs have been developed. Ceritinib is a second‐generation ALK‐TKI and has shown great efficacy in the treatment of patients with both newly diagnosed and crizotinib (a first‐generation ALK‐TKI)‐refractory ALK‐rearranged NSCLC. However, tumors can also develop ceritinib resistance. This may result from secondary ALK mutations, but other mechanisms responsible for this have not been fully elucidated. In this study, we explored the mechanisms of ceritinib resistance by establishing ceritinib‐resistant, echinoderm microtubule‐associated protein‐like 4 (EML4)‐ALK–positive H3122 cells and ceritinib‐resistant patient‐derived cells. We identified a mechanism of ceritinib resistance induced by bypass signals that is mediated by the overexpression and activation of fibroblast growth factor receptor 3 (FGFR3). FGFR3 knockdown by small hairpin RNA or treatment with FGFR inhibitors was found to resensitize the resistant cells to ceritinib in vitro and in vivo. FGFR ligands from either human serum or fetal bovine serum were able to activate FGFR3 and induce ceritinib resistance. A detailed analysis of ceritinib‐resistant patient‐derived specimens confirmed that tyrosine‐protein kinase Met (cMET) amplification induces ceritinib resistance. Amplified cMET counteractivated EGFR and/or Her3 and induced ceritinib resistance. These results reveal multiple ceritinib resistance mechanisms and suggest that ceritinib resistance might be overcome by identifying precise resistance mechanisms.
Primary implant stability based on alternative site preparation techniques: A systematic review and meta‐analysis
Authors: Yu Xinbo , Chang Cheng , Guo Wennan , Wu Yiqun , Zhou Wenjie , Yu Dedong 
Published: August 2022

AbstractAimTo evaluate the effect of special implant site preparation methods in improving primary implant stability in low‐density bone.Material and MethodsThis meta‐analysis included studies published in English and Mandarin Chinese up to March 31, 2022 from MEDLINE/PubMed, Embase, Scopus, and Wanfang databases. The primary stability of five site preparation methods were measured using implant stability quotient. The random‐effects model was chosen for data analysis. Grading of recommendations assessment, development, and evaluation assessment was adopted as a collective grading of the overall body of evidence.Results12 of the 17 studies included in the meta‐analysis were randomized control trials. Three studies investigated osseodensification drilling (OD), eight studies examined osteotome technique (OT), five studies explored piezosurgery (PS), and four studies were conducted on under‐drilling (UD). Meta‐analysis showed a statistically significant increase in primary stability for the OD (mean difference [MD], 10.25; 95% CI: 4.97–15.52; p < 0.001), OT (MD, 6.34; 95% CI: 2.26–10.42; p = 0.002), and UD (MD, 11.43; 95% CI: 5.17–17.68; p < 0.001) groups when compared to the conventional drilling group, while the PS group did not (MD, 1.50; 95% CI: −2.54–5.54; p = 0.47).ConclusionSignificantly higher primary implant stability was shown in the OD, UD, and OT groups compared to the conventional drilling group. PS displayed the least favorable primary stability and when compared to conventional drilling, was not statistically significant.