bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the clinical and radiological outcomes of percutaneous cervical nucleoplasty: A case–control study
Authors: Chen Chien-Hua , Chiu You-Pen , Ji Hui-Ru , Wu Chin-Ying , Guo Jeng-Hung , Jaw Fu-Shan , Chiu Cheng-Di 
Published: December 2022

Background
Percutaneous cervical nucleoplasty (PCN) is a simple, safe, and effective treatment for contained cervical herniated intervertebral disc (CHIVD). However, few studies have compared the actual benefits of PCN against conservative treatment (CT), either clinically or radiographically.

Purpose
The present study sought to analyze and to compare the outcomes of symptomatic contained CHIVD treated with PCN or CT.

Methods
The present study was designed as a case–control comparative study. Patients who indicated for PCN after a failed CT for more than 6 months were recruited. After the exclusion of some patients who did not meet the selection criteria of the study, we finally enrolled 71 patients treated with PCN. In addition, another 21 patients who indicated for PCN but finally chose to receive CT continuously were also enrolled and categorized as the control group. All patients completed the 6-month follow-up. Pain levels and functional outcomes were evaluated pre- and post-operatively by assessing the visual analog scale (VAS), Oswestry Disability Index (ODI), and Neck Disability Index (NDI). Radiographic images of 72 of 104 intervened segments were collected to measure disc height and other cervical spinal alignments, such as range of motion, C2–7 Cobb’s angle, and C2–7 sagittal vertical axis.

Results
Compared with the CT group, the PCN group showed significantly better outcomes on VAS, ODI, and NDI at the 1-month post-operative follow-up, which continued through at least the 6-month follow-up (P < 0.01 for VAS and P < 0.05 for ODI and NDI). The mean disc height significantly decreased, from 6.04 ± 0.85 mm to 5.76 ± 1.02 mm, 3 months after PCN treatment (P = 0.003). However, the degree of disc height decrease did not correlate with the changes of the substantial VAS improvement.

Conclusions
To provide therapeutic benefits for symptomatic contained CHIVD patients after an invalid CT for 6 months, PCN seems to be a better option than CT. The reduced disc heights did not alter the clinical outcomes of PCN.
Review on Application of NMR Spectroscopy to study Parkinson's Disease
Authors: Pillai Lakshmi , Nangia Aayushi , Nair Athira , Saravanan Janani , Hazra Shruti 
Published: December 2022

Objective
Metabolite changes in biofluids, tissues and tumours can be studied to identify metabolomic changes to correlate them to a disease (PD produces disturbances in the metabolome). The biomarkers for the same are recognized by monitoring these changes. Complicated biological samples such as cerebrospinal fluid (CSF), blood and urine can be analysed using NMR spectroscopy that aids in increasing the translation of information. The different types of NMR include proton NMR (H-NMR), Carbon NMR (C-NMR), Heteronuclear Single Quantum Coherence (HSQC), Heteronuclear Multiple Bond Correlation (HMBC) and so on.

Background
NMR is based on the measurement of proton wide-line spectra in its early stages. Later on, the deuteron NMR (2H NMR) technique gained popularity since it offered information about polymer molecular processes. The solid-state NMR (SSNMR) approach, as well as the 13C cross-polarization magic angle spinning NMR (13C CP/MAS NMR), gained popularity after that. The proton high-resolution magic angle spinning NMR (HR-MAS NMR) was created after that for use in biomedical applications. Additional information, such as molecular reorientations of some nuclei, such as 13C, 15N, or 31P, has been obtained using two-dimensional (2D) NMR.

Methods
The application of NMR consists of a typical one-dimensional (1D) 1H NMR spectrum that can be acquired in a few minutes using an automated high throughput protocol. An important potential of metabolomics is the identification of biomarkers to diagnose PD, to monitor disease progression, and to evaluate a patient’s response to treatment. Thus, one of the primary goals of metabolomics is to identify the specific metabolites significantly perturbed in response to a disease state. Critical information on cellular processes, molecular interactions and metabolic pathways associated with PD is thus obtained.

Results/Advantages
NMR based techniques eliminate the need of ionizing radiation, helping in avoiding exposure to harmful X-Rays. A wide range of biological processes can be studied. Combination of NMR spectroscopy and imaging helps obtain a large amount of anatomical, physiological, and metabolic data with just a single experiment. NMR techniques have a non-destructive nature, minimal sample handling, high throughput and high reproductivity.

Conclusion
This poster illuminates a brief analysis/detection of NMR metabolomics of Parkinson's disease. Metabolomics plays a huge role in the identification of possible biomarkers, metabolic mechanisms and inception of the disease progression. NMR metabolomics has a great potential in assisting the analysis/detection of the PD biomarkers, identifying novel biomarkers to diagnose PD, aid in drug discovery and the development of personalized medicine.
Congestion Prediction in Internet of Things Network using Temporal Convolutional Network A Centralized Approach
Authors: Jain Vinesh Kumar , Mazumdar Arka Prokash , Govil Mahesh Chandra 
Published: December 2022

The unprecedented ballooning of network traffic flow, specifically, Internet of Things (IoT) network traffic, has big stressed of congestion on todays Internet. Non-recurring network traffic flow may be caused by temporary disruptions, such as packet drop, poor quality of services, delay, etc. Hence, the network traffic flow estimation is important in IoT networks to predict congestion. As the data in IoT networks is collected from a large number of diversified devices which have unlike format of data and also manifest complex correlations, so the generated data is heterogeneous and nonlinear in nature. Conventional machine learning approaches unable to deal with nonlinear datasets and suffer from misclassification of real network traffic due to overfitting. Therefore, it also becomes really hard for conventional machine learning tools like shallow neural networks to predict the congestion accurately. Accuracy of congestion prediction algorithms play an important role to control the congestion by regulating the send rate of the source. Various deeplearning methods (LSTM, CNN, GRU, etc.) are considered in designing network traffic flow predictors, which have shown promising results. In this work, we propose a novel congestion predictor for IoT, that uses Temporal Convolutional Network (TCN). Furthermore, we use Taguchi method to optimize the TCN model that reduces the number of runs of the experiments. We compare TCN with other four deep learning-based models concerning Mean Absolute Error (MAE) and Mean Relative Error (MRE). The experimental results show that TCN based deep learning framework achieves improved performance with 95.52% accuracy in predicting network congestion. Further, we design the Home IoT network testbed to capture the real network traffic flows as no standard dataset is available.
Numerical studies of the simultaneous development of forced convective laminar flow with heat transfer inside a microtube at a uniform temperature
Authors: Hamad Raisan F. , Smaisim Ghassan F. , Abed Azher M. 
Published: December 2022

Abstract
Conjugate heat transfer is a complex problem because heat is transferred from a solid medium to a liquid medium through their interfaces. The steady-state laminar flow formed inside the microtubules is subjected to a constant temperature at the outer sidewall surface. These images cover a wide range of wall-to-fluid thermal conductivity ratios (ksf = 1, 2, 3, 4, and 5) and wall thickness-to-inner diameter ratios (δ/Ri = 0.25, 0.5, 0.75, 1, 1.25, and 1.5) and Reynolds numbers (Re = 200, 400, 600, 800, and 1,000). The results are processed by a Fluent program based on the finite volume method to numerically integrate the driver’s differential equations. The results show that increasing the wall-to-fluid thermal conductivity ratio ksf increases the inner wall dimensionless temperature and decreases the average Nusselt number. Conversely, an increase in the ratio of wall thickness to inner diameter results in a decrease in the dimensionless temperature of the inner wall and an increase in the average Nusselt number.
Effect of third trimester maternal vitamin D levels on placental weight to birth weight ratio in uncomplicated pregnancies
Authors: Kirlangic Mehmet Mete , Sade Osman Sertac , Eraslan Sahin Mefkure 
Published: December 2022

Abstract

Objectives
Vitamin D has critical role for the fetal and placental development. Today, placental weight (PW), fetal birth weight (BW), and the PW/BW ratio are used as markers of fetal development. The aim of this study is to evaluate the relationship between vitamin D levels and these markers in uncomplicated pregnancies.

Methods
This study included 108 women with uncomplicated pregnancies, defined as full-term and healthy pregnancies without perinatal complications. Vitamin D levels <12 ng/mL were classified as deficient, 12–20 ng/mL as insufficient, and >20 ng/mL as normal. Postnatal BW and PW were compared according to maternal serum vitamin D levels.

Results
Maternal age, maternal height, maternal weight, body mass index, nulliparity, gestational age at delivery, mode of delivery, and fetal gender were similar between groups. Postnatal BW, PW, fetal height at birth, and fetal head circumference parameters were similar between the groups. The PW/BW ratio was 21.77±2.20 in the vitamin D deficient group, 21.20±2.40 in the insufficient group, and 19.98±2.37 in the normal group (p=0.012). In addition, there was a significant negative correlation between vitamin D level and the PW/BW ratio (p=0.012, r=0.031).

Conclusions
Our results indicated that PW/BW ratio which is the marker for prediction adverse perinatal outcomes were significantly increased in the presence of vitamin D deficiency and insufficiency.
The effects of draw restrictions on knockout tournaments
Authors: Csató László 
Published: December 2022

Abstract
The paper analyses how draw constraints influence the outcome of a knockout tournament. The research question is inspired by European club football competitions, where the organiser generally imposes an association constraint in the first round of the knockout phase: teams from the same country cannot be drawn against each other. Its effects are explored in both theoretical and simulation models. An association constraint in the first round(s) is found to increase the likelihood of same nation matchups to approximately the same extent in each subsequent round. If the favourite teams are concentrated in some associations, they will have a higher probability to win the tournament under this policy but the increase is less than linear if it is used in more rounds. Our results might explain the recent introduction of the association constraint for both the knockout round play-offs with 16 teams and the Round of 16 in the UEFA Europa League and UEFA Europa Conference League.
Begegnungen mit dem Anderen – das Konfessionskundliche Institut Bensheim wird 75 Jahre
Authors: Bräuer Martin 
Published: December 2022

Zusammenfassung
In diesem Beitrag wird zunächst ein Blick auf die Geschichte und Entwicklung des Konfessionskundlichen Instituts von 1947 bis heute geworfen. Stand in den ersten Jahren und Jahrzehnten vor allem die römisch-katholische Kirche in Deutschland und Europa im Zentrum der Arbeit, so fächerten sich ab der zweiten Hälfte der sechziger Jahre die Aufgaben immer mehr auf. In einem zweiten Teil wird auf die Methoden der konfessionskundlichen Arbeit geschaut und dargelegt, wie heute diese Arbeit methodisch geschieht.
El déficit de formulación de la política pública de la infraestructura vial nacional de 1998
Authors: Vasquez Rodriguez Jorge Alberto 
Published: December 2022

La reorientación de la política pública de la infraestructura vial nacional de 1998 incorporó aspectos claves del Nuevo Estilo Nacional de Desarrollo vigente en el país en el momento de su oficialización. Este estilo desde principios de los años 80 promulga el protagonismo del mercado, en deterioro del papel del Estado, de ahí, que concordante con el mismo se trasladó la construcción, conservación y mantenimiento de la Red Vial Nacional del Estado al empresario privado, mediante contrataciones administrativas a cargo de un ente público denominado el Consejo Nacional de Vialidad, en donde en su consejo de administración, máximo jerarca de esa institución, estarían incorporados tres miembros de los empresarios organizados del mercado de la construcción de carreteras, con voz y voto, que coadministrarían la institución, con otros tres miembros representantes del gobierno de turno y uno de los gobiernos locales, con recursos provenientes de un Fondo Vial Nacional.
La formulación de la política presenta un déficit de formulación, generada principalmente por la reformulación del problema público y de la estrategia de intervención de la política pública, generada desde “lo político” en la Asamblea Legislativa en el primer cuatrimestre de 1998, de ahí, que no se le brindó una posible respuesta a algunas de las causas del problema público como la relocalización de servicios, las expropiaciones, la coordinación con entes públicos que determinan el avance de la obra vial, la protección del medio ambiente, el control y calidad de las carreteras, el control excesivo sobre las obras viales, ejercidos directamente o indirectamente por entes públicos controladores, generándose así un déficit de formulación en la política pública, que incide negativamente en los resultados de la misma
The Alphabet of Architecture. Originality and Literacy in the Theory of Profiles
Authors: Delbeke Maarten 
Published: December 2022

In 1691 Augustin-Charles D’Aviler published his Cours d’architecture qui comprend les ordres de Vignole. Ostensibly one of the many extended editions of Vignola’s Regola delli cinque ordini d’architettura (1562) that would appear over the course of the 16th and 17th century, D’Aviler’s Cours is in fact an expansive and not always systematic compendium on design and construction, covering subjects ranging from the design of locks to the layout of the princely residence. Still, the Cours opens with a short biography of Vignola and is dedicated for its first part to the five orders discussed by the Italian architect. But before D’Aviler dives into the proportions of the Tuscan order, the first and lowest of the five, he treats an altogether different subject: mouldings. Over three sections D’Aviler develops a small design theory of the subject: “des moulures, et de la manière de les bien profiler”, “des ornemens des moulures” and “du choix des profiles”.
A closer look at these sections will show how D’Aviler deals with concerns and anxieties related to the two foundational creative acts of classicism: imitation and invention. The moulding is an architectural element that allows D’Aviler to explore the tension between these two creative acts, thanks to its intricate composition and its capacity to articulate the surface of a building. He does so in the pages of a printed treatise. This medium frames the matters of imitation and invention in terms of literacy and replication. D’Aviler constructs in words and image a vocabulary that allows for the reproduction of the principles he proposes. Thanks to the medium of the treatise, these principles can be taught and reproduced, an effect most apparent in the considerable afterlife of his theory of mouldings.
Prevalence of mutations in DNA repair genes in Russian patients with metastatic castration-resistant prostate cancer
Authors: Mailyan O. A. , Kalpinskiy A. S. , Reshetov I. V. , Anzhiganova Yu. V. , Nyushko K. M. , Kaprin А. D. , Golovashchenko M. P. , Kokin S. P. , Stakanov V. A. , Alekseev B. Ya. 
Published: December 2022

Background. Prostate cancer is one of the most common malignant tumors in men. Tailored treatment approaches to metastatic castration-resistant prostate cancer based on identification of specific biomarkers have been introduced only recently. So far, the Food and Drug Administration has approved two drugs (olaparib and rucaparib) targeting the DNA repair genes.Aim. To assess the frequency of mutations in the DNA repair genes in the Russian population.Materials and methods. The article uses data from two centers (National Medical Research Radiological Center and A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncological Dispensary) which included the largest numbers of patients in the largest Russian multicenter prospective trial ADAM. We performed genotyping of all valid tumor samples from 113 patients with metastatic castration-resistant prostate cancer to identify clinically significant mutations in the DNA repair genes.Results. Next-generation sequencing demonstrated that 27 patients (23.9 %) had clinically significant mutations in DNA repair genes were, including ATM in 6 (5.3 %), BRCA1 in 5 (4.4 %), BRCA2 in 4 (3.5 %), CDK12 in 3 (2.6 %), CHEK2 in 2 (1.8 %), PALB2 in 2 (1.8 %), BRIP1 in 2 (1.8 %), BARD1 in 1 (0.9 %), RAD51B in 1 (0.9 %), and RAD51C in 1 patient (0.9 %).Conclusion. Identification of mutations in the DNA repair genes should become a routine procedure, since a new treatment approach to metastatic castration-resistant prostate cancer is now being introduced.
Prevalence, Demographic Characteristics and Comorbid Psychiatric Disorders in Children and Adolescents with Substance Use Disorder in Iran
Authors: Mohammadi Mohammad Reza , Hojjat Seyed Kaveh , Khaleghi Ali , Hooshyari Zahra , Mostafavi Seyed-Ali , Alavi Seyyed Salman , Ahmadi Nastaran , Kaviyani Faezeh , Ahmadi Ameneh , Armani Kian Alireza , Sarraf Nasrin , Safavi Parvin , Norozi Khalili Mina , Talepasand Siavash , Amiri Shahrokh , Molavi Parviz , Akbari Hadi , Arman Soroor , Mohammadzadeh Soleiman , Kousha Maryam , Golbon Atieh , Hosseini Seyed Hamzeh , Delpisheh Ali , Mojahed Azizollah , Moharari Fatemeh , Dastjerdi Reza , Jaberghaderi Nasrin , Ostovar Rahim , Mohammadi Moghadam Mehriar Nadr , Salmanian Maryam , Zarafshan Hadi 
Published: December 2022

Background: The present study aimed to investigate the prevalence of substance use disorder in Iranian children and adolescents and its relationship with demographic characteristics and psychiatric comorbidities.
Methods: The data were taken from a national survey on the prevalence of psychiatric disorders in Iranian children and adolescents. The national survey was conducted on 30,532 children and adolescents aged 6-18 years which were selected using multistage cluster sampling. The psychiatric disorders were assessed by employing k-SADS-PL questionnaire and interviews carried out by 240 clinical psychologists with the participants and their parents. Data were analyzed by Chi-square test and logistic regression.
Results: A total of 277 (0.97%) were diagnosed as people with substance use disorder that were further studied for comorbid disorders. Among the various types of drugs, hypnotic/sedative/anti-anxiety drugs were abused by 84 people (46.15%), cannabis by 68 (37.36%) and stimulants by 43 (23.63%). The variables of gender, place of residence, and father’s occupation and parents’ education level were identified as predictors of substance use disorder in children and adolescents. At the same time, 42.50% substances and alcohol abusing people had at least one comorbid psychiatric disorder and the highest comorbidity was observed in oppositional defiant disorder, attention deficit and hyperactivity disorder and separation anxiety disorder (p≤0.05).
Conclusion: The findings can be used in the prevention and treatment of substance use disorder and promotion of mental health in children and adolescents by focusing on the psychiatric comorbidities of people with substance use disorder.
What does mash suffer from, or fungal diseases of the <I>Vigna radiate</I>
Authors: Kurkina Yu. N. 
Published: December 2022

Relevance. Mash (Vigna radiate (L.) R.Wilczek) is a very ancient Asian legume plant, which, thanks to a number of advantages, may become an important vegetable crop in Russia. Young fruits and seeds of Vigna radiate are rich in protein, vitamins A, B, C, PP, iron, folic acid, and taste like green peas. A lot of essential amino acids and a low glycemic index make it possible to use even mature mash seeds for the preparation of dietary food. To preserve the harvest, it is important to know the diseases of the crop.Methods. For a number of years, a sample of the radiant vigna VR-2014 (Vietnam) has been studied on a natural infectious background in the soil and climatic conditions of the Belgorod region (Russia). Field tests and mycological studies made it possible to determine the species composition of phytopathogenic microscopic fungi, describe the symptoms and compare the main elements of accounting for mycoses.Results. The length of the growing season of the radiant vigna did not exceed 83 days, the appearance of seedlings was noted on 10-12 days from sowing, flowers – on 68-73 days. The height of the plants did not exceed 40 cm. Ascochytosis (the causative agent of Ascochyta boltschauseri) led to losses of 82% of seed productivity, with an average prevalence of 40% and the development of the disease of 2.5 points. Ascochitosis reduced the values of all elements of seed productivity: the length and number of fruits, the mass of 1000 seeds, but most of all (by 5 times) the weight of fruits and seeds from the plant decreased. Peronosporosis (the causative agent of Peronospora fabae) led to losses of seed productivity by 16%, root rot (the causative agent of Bipolaris australensis) and fomosis (the causative agent of Phoma diversispora) – by 17% and 11%, respectively. Spotting was the leading symptom of mycoses of Vigna radiate, and the most harmful phytopathogenic fungi were representatives of the ground-air group of pathogens.
Influence of predecessors, mineral fertilizers and humate on the infestation of crops with weeds and the yield of chicory roots
Authors: Vyutnova O. M. , Smirnova I. V. , Novikova I. A. , Maksimova K. S. 
Published: December 2022

Relevance. For the cultivation of environmentally friendly products, the preservation of soil fertility and environmental protection, the question of the prospects for longterm use of various fertilizer systems is very important. With an acute shortage of manure, a mineral-biological fertilizer system is promising, when an estimated dose of mineral fertilizers is applied against the background of annually sown siderates. Such a system of fertilizer application makes it possible to increase yields, product quality, significantly reduce the shortage of organic matter in the soil, improve its structure and biological activity. The inclusion of the employed steam with the most effective precursors, doses of mineral macro and micro fertilizers and humic acids in the rowed link of crop rotation can reduce the contamination of crops and significantly increase the yield of root chicory root crops.Materials and methods. The research was carried out in 2017-2021 located in the Rostov district of the Yaroslavl region.Results. As a result of the conducted research, it was found that on turf-podzolic medium-loamy soils of the Non-Chernozem zone of the Russian Federation, it is economically feasible to use technology for the cultivation of root chicory using an oatpea mixture as a precursor in combination with the introduction of mineral fertilizers into the soil at a dose of N60P60K120 and the treatment of vegetative plants with boron and humate. When using this technology, the contamination of crops decreases, their photosynthetic potential and the yield of root crops increases, the cost of production decreases, and the profitability exceeds 104%.