bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter, randomized controlled trial of traditional Japanese medicine, kakkonto with shosaikotokakikyosekko, for mild and moderate coronavirus disease patients
Authors: Takayama Shin , Namiki Takao , Arita Ryutaro , Ono Rie , Kikuchi Akiko , Ohsawa Minoru , Saito Natsumi , Suzuki Satoko , Nakae Hajime , Kobayashi Seiichi , Yoshino Tetsuhiro , Ishigami Tomoaki , Tanaka Koichiro , Nochioka Kotaro , Takagi Airi , Mimura Masaru , Yamaguchi Takuhiro , Ishii Tadashi , Hisanaga Akito , Mitani Kazuo , Ito Takashi 
Published: November 2022

The traditional Japanese (Kampo) medicine, kakkonto with shosaikotokakikyosekko, has antiviral and anti-inflammatory effects. In this randomized trial, patients with mild and moderate coronavirus disease (COVID-19) were randomly allocated to the control group receiving conventional treatment for symptom relief such as antipyretics and antitussives or the Kampo group receiving mixed extract granules of kakkonto (2.5 g) and shosaikotokakikyosekko (2.5 g) three times a day for 14 days in addition to conventional treatment. The main outcome was the number of days until total symptom relief. The secondary outcome was the number of days until each symptom’s relief and whether the disease progressed to respiratory failure. We enrolled a total of 161 patients (Kampo group, n = 81; control group, n = 80). The results from Kaplan–Meier estimates of symptom relief showed that there are no significant differences between the groups. However, covariate-adjusted cumulative incidence of fever relief considering competitive risk showed that the recovery was significantly faster in the Kampo group than in the control group (HR 1.76, 95% CI 1.03–3.01). Additionally, the risk of disease progression to moderate COVID-19 requiring oxygen inhalation was lower in the Kampo group than in the control group (Risk Difference −0.13, 95% CI −0.27–0.01). No significant drug-related side effects were observed. Kakkonto with shosaikotokakikyosekko is effective for fever relief with suppression of disease progression in COVID-19 patients.Clinical Trial Registration:https://jrct.niph.go.jp/en-latest-detail/jRCTs021200020, identifier [jRCTs021200020]
Effectiveness and safety of treating carotid atherosclerotic plaques with the method of nourishing qi, promoting blood circulation and expelling phlegm: A systematic review and meta-analysis
Authors: Li Jia , Du Yuying , Cai Chao , Liu Fuming 
Published: November 2022

Objectives: This meta-analysis aimed at evaluating the effectiveness and safety of Chinese medicine (TCM), which nourished qi, promoted blood circulation, and expelled phlegm (YQHXZT), in treating carotid atherosclerosis (CAS) from an immunological perspective.Background: The incidence of CAS has been increasing and tends to be younger. Although western medicine is effective, there are some limitations. TCM has certain advantages over the multichannel and multitarget treatment strategies in slowing down the process of CAS. However, there is no comprehensive review in this field.Methods: Nine databases were searched from January, 2012, to September, 2022. After applying the inclusion and exclusion criteria to the RCTs, research quality evaluation and data extraction were conducted, and a meta-analysis of the articles was performed. The GRADE was used to assess the quality of the evidence.Results: Fourteen RCTs involving 1,191 patients were identified. The results indicated that the experimental group was more effective in improving carotid intima-media thickness (CIMT)[SMD = −0.97, 95%CI(−.30,−0.65), p &lt; 0.00001], reducing carotid plaque area [SMD = −1.98, 95%CI(−3.06,−0.89), p = 0.0003], lowering hs-CRP [SMD = −1.33, 95%CI(−1.59,-1.06), p &lt; 0.00001] and LDL-C levels [SMD = −0.60, 95%CI(−0.83,-0.38), p &lt; 0.00001]. Moreover, the experimental group was superior to peak systolic blood flow velocity (PSV) [SMD = −0.37, 95%CI(−0.59,−0.16), p = 0.0007], clinical efficacy [RR = 1.64, 95% CI (1.39, 1.94), p &lt; 0.00001] and plaque area efficacy [RR = 1.36, 95% CI (1.22, 1.52), p &lt; 0.0001]. The adverse reactions were not statistically significant in the two groups [RD = -0.01, 95% CI (-0.04.0.01), p = 0.17]. The results of grade evaluation suggested that the outcome indicators LDL-C, hs-CRP, plaque area efficacy, PSV, and adverse events were moderate. CIMT, plaque reduction area, and TCM clinical efficacy were low-quality.Conclusion: The combination of YQHXZT can alleviate the process of CAS by inhibiting the thickening of CIMT, reducing plaque area and lowering hs-CRP and LDL-C levels. The mechanism may possibly be related to reducing lipid deposition and inhibiting the inflammatory response. Besides, the combination did not increase the risk of adverse effects. However, more well-designed RCTs are needed in the future.Systematic review registration: CRD42022360529, https://www.crd.york.ac.uk/prospero/
Financial crisis prediction based on multilayer supervised network analysis
Authors: Qiu Lu , Su Rongpei , Wang Zhouwei 
Published: November 2022

Financial crisis prediction is essential in preventing financial problems as its monitoring indicators help regulators judge the probability of future crises. In this context, the activities of the scientific community have been focused on the dynamics of single/multiple sequences and utilized unsupervised/supervised methods for financial crisis prediction. It is noteworthy that the cross-correlation between the risks of multiple economic entities makes financial network analysis paramount in crisis prediction. Focusing on this point, we propose a multilayer supervised network analysis (MSNA) method to train the multilayer network, and select the most suitable layer for financial crisis prediction. Specifically, we use 37 crucial stock market indices from 4 continents to create successive multilayer financial networks with 120-day windows and 1-day step by Pearson cross-correlation (PCC), variance decompositions (VD), transfer entropy (TE), minimum spanning tree (MST), directed MST (DMST), planar maximally filtered graph (PMFG) and directed PMFG (DPMFG) methods. Based on the multilayer network, we embed the graph neural network classification (GNNC) model and train the dynamic multilayer networks at each window scale (240,120, and 60 days). Finally, we conclude that the accuracy of the short window (60 days) is significantly higher than that of the long window. The network constructed by PCC with MST is the most suitable for short sequence (60 days) crisis prediction (AUC = 0.959), and the network constructed by TE with DMST is the most suitable for long sequence (240 days) crisis prediction (AUC = 0.772).
On-field low-frequency fatigue measurement after repeated drop jumps
Authors: Ridard Jade , Rozand Vianney , Millet Guillaume Y. , Lapole Thomas 
Published: November 2022

Purpose: Monitoring fatigue is now commonly performed in athletes as it can directly impact performance and may further increase the risk of injury or overtraining syndrome. Among the exercise-induced peripheral alterations, low-frequency fatigue (LFF) assessment is commonly restricted to in-lab studies. Measuring LFF on-field would allow athletes and coaches to assess muscle fatigability on a regular basis. The aim of the present study was therefore to validate a new portable device allowing quadriceps LFF assessment in the field.Methods: LFF was assessed in 15 active and healthy participants before (PRE) and after (POST) a series of drop jumps. LFF was assessed, thanks to a dedicated device recording evoked force to muscle submaximal electrical low- and high-frequency stimulation. Changes in the low- to high-frequency force ratio (further referred to as Powerdex® value) were compared to the changes in the ratio of evoked force induced by paired-pulse femoral nerve electrical stimulation at 10 and 100 Hz (i.e., DB10/DB100 ratio). Maximal voluntary contraction (MVC) and voluntary activation (VA) were also measured.Results: MVC decreased (p &lt; 0.001), whereas VA was not affected by the fatiguing task (p = 0.14). There was a decrease in the DB10/DB100 ratio (from 96.4% to 67.3%, p &lt; 0.001) as well as in the Powerdex value (from 74.0% to 55.7%, p &lt; 0.001). There was no significant difference between POST values (expressed in percentage of PRE values) of the DB10/DB100 ratio and Powerdex (p = 0.44), and there was a significant correlation between the changes in Powerdex® and DB10/DB100 (r = 0.82, p &lt; 0.001).Conclusion: The on-field device we tested is a valid tool to assess LFF after a strenuous exercise consisting of repeated drop jumps as it evidences the presence of LFF similarly to a lab technique. Such a device can be used to monitor muscle fatigability related to excitation–contraction in athletes.
Risk factors and preventive strategies for post-traumatic stress disorder in neonatal intensive care unit
Authors: Di Chiara Maria , Laccetta Gianluigi , Gangi Sara , De Santis Benedetta , Spiriti Caterina , Attenni Martina , Bertolaso Laura , Boscarino Giovanni , De Nardo Maria Chiara , Ciambra Gianluca , Parisi Pasquale , Terrin Gianluca 
Published: November 2022

BackgroundPreterm birth and admission to the neonatal intensive care unit (NICU) could induce post-traumatic stress disorder (PTSD). PTSD is an important factor to focus on, as it is associated with parental mental health difficulties and with changes in caregiving quality such as increased intrusiveness, reduced sensitivity, and increased attachment insecurity for the child.AimsWe aimed to study the main risk factors, in the early life of newborns, and preventive measures for PTSD in parents of neonates hospitalized in the NICU.MethodsWe included parents of preterm newborns, consecutively admitted to the NICU of the University La Sapienza of Rome. The presence of PTSD following preterm birth and NICU admission was assessed using the Clinician-administered PTSD scale (CAPS) at enrollment and at 28–30 days following NICU admission or the moment of discharge. We also evaluated the Family Environment Scale which measures the social environment of all types of families; the Parental Stressor Scale which measures parental anxiety and stress; the Spielberger State-Trait Anxiety Inventory consisting of two parts measuring the State (response to present situation) and Trait (pre-disposition to be anxious) anxieties separately, and the Beck Depression Inventory Second Edition assessing depressive symptoms.ResultsWe found, in a multivariate analysis, that the gestational age of newborns admitted to NICU significantly (β = 2.678; p = 0.040) influences the occurrence of PTSD. We found that the cases showed significantly (β = 2.443; p = 0.020) more pathological Parental Stressor Scale sights and sounds scores compared to controls. The early Kangaroo-Care (KC) significantly (β = −2.619; p = 0.015) reduces the occurrence of PTSD.ConclusionPost-traumatic stress disorder in parents of preterm newborns is a pathological condition that should be properly managed, in the very first days after birth. The NICU environment represents a main risk factor for PTSD, whereas KC has been demonstrated to have a protective role in the occurrence of PTSD.
The influence of parent–child attachment on school adjustment among the left-behind children of overseas Chinese: The chain mediating role of peer relationships and hometown identity
Authors: Zhang Huilan , Li Zihan , Yan Xiaoqiu , Deng Chunkao 
Published: November 2022

BackgroundThe left-behind children of overseas Chinese are a kind of vulnerable children in the eastern coastal areas of China. Previous studies have shown that there are problems in their school adjustment. This study explored the relationship between parent–child attachment and school adaptation among the left-behind children of overseas Chinese parents, as well as the chain mediating role of peer relationships and hometown identity.MethodsA total of 1,047 students in grades 3–8 from 5 schools in Zhejiang Province were selected by cluster sampling. The cross-sectional survey was compiled from the Inventory of Parent and Peer Attachment, the Adaptation subscale of the Adolescent Mental Health Quality Questionnaire–Chinese Version, the Hometown Identity Scale, and the Student Peer Relationship Scale. Structural equation modeling was used to test the conceptual model.ResultsThe results showed that the influence of parent–child attachment on school adjustment among the left-behind children of overseas Chinese was mediated by hometown identity. Moreover, this impact was also sequentially mediated by peer relationships and hometown identity.ConclusionThis study revealed peer relationships and hometown identity as underlying mechanism that explained the influence of parent–child attachment on school adjustment among left-behind children. It may provide empirical support for future interventions.
Altered striatal functional connectivity and structural dysconnectivity in individuals with bipolar disorder: A resting state magnetic resonance imaging study
Authors: Okanda Nyatega Charles , Qiang Li , Jajere Adamu Mohammed , Bello Kawuwa Halima 
Published: November 2022

ObjectiveBipolar disorder (BD) is a mood swing illness characterized by episodes ranging from depressive lows to manic highs. Although the specific origin of BD is unknown, genetics, environment, and changes in brain structure and chemistry may all have a role. Through magnetic resonance imaging (MRI) evaluations, this study looked into functional abnormalities involving the striatum between BD group and healthy controls (HC), compared the whole-brain gray matter (GM) morphological patterns between the groups and see whether functional connectivity has its underlying structural basis.Materials and methodsWe applied sliding windows to functional magnetic resonance imaging (fMRI) data from 49 BD patients and 44 HCs to generate temporal correlations maps to determine strength and variability of the striatum-to-whole-brain-network functional connectivity (FC) in each window whilst also employing voxel-based morphometry (VBM) to high-resolution structural MRI data to uncover structural differences between the groups.ResultsOur analyses revealed increased striatal connectivity in three consecutive windows 69, 70, and 71 (180, 182, and 184 s) in individuals with BD (p &lt; 0.05; Bonferroni corrected) in fMRI images. Moreover, the VBM findings of structural images showed gray matter (GM) deficits in the left precentral gyrus and middle frontal gyrus of the BD patients (p = 0.001, uncorrected) when compared to HCs. Variability of striatal connectivity did not reveal significant differences between the groups.ConclusionThese findings revealed that BD was associated with a weakening of the precentral gyrus and middle frontal gyrus, also implying that bipolar illness may be linked to striatal functional brain alterations.
Potential mechanisms underlying the therapeutic roles of sinisan formula in depression: Based on network pharmacology and molecular docking study
Authors: Wang Hui , Liu Jiaqin , He Jinbiao , Huang Dengxia , Xi Yujiang , Xiao Ting , Ouyang Qian , Zhang Shiwei , Wan Siyan , Chen Xudong 
Published: November 2022

BackgroundThe incidence of depression has been increasing globally, which has brought a serious burden to society. Sinisan Formula (SNSF), a well-known formula of traditional Chinese medicine (TCM), has been found to demonstrate an antidepressant effect. However, the therapeutic mechanism of this formula remains unclear. Thus, the present study aimed to explore the mechanism of SNSF in depression through network pharmacology combined with molecular docking methods.Materials and methodsBioactive compounds, potential targets of SNSF, and related genes of depression were obtained from public databases. Essential ingredients, potential targets, and signaling pathways were identified using bioinformatics analysis, including protein-protein interaction (PPI), the Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, Autodock software was further performed for conducting molecular docking to verify the binding ability of active ingredients to targets.ResultsA total of 91 active compounds were successfully identified in SNSF with the use of the comprehensive network pharmacology approach, and they were found to be closely connected to 112 depression-related targets, among which CREB1, NOS3, CASP3, TP53, ESR1, and SLC6A4 might be the main potential targets for the treatment of depression. GO analysis revealed 801 biological processes, 123 molecular functions, and 67 cellular components. KEGG pathway enrichment analysis indicated that neuroactive ligand-receptor interaction, serotonergic synapse pathways, dopaminergic synapse pathways, and GABAergic synapse pathways might have played a role in treating depression. Molecular docking suggested that beta-sitosterol, nobiletin, and 7-methoxy-2-methyl isoflavone bound well to the main potential targets.ConclusionThis study comprehensively illuminated the active ingredients, potential targets, primary pharmacological effects, and relevant mechanism of the SNSF in the treatment of depression. SNSF might exert its antidepressant effects by regulating the signaling pathway of 5-hydroxytryptamine, dopamine, GABA, and neuroactive ligand receptor interactions. Still, more pharmacological experiments are needed for verification.
Neuropsychological predictors of vocational rehabilitation outcomes in individuals with major depression: A scoping review
Authors: Bergdolt Juliane , Sellin Pauline , Driessen Martin , Beblo Thomas , Dehn Lorenz B. 
Published: November 2022

BackgroundMajor depression is one of the leading causes of disability and limited capacity to work. Neuropsychological impairment is a common symptom in acute and remitted major depression and is associated with poor psychosocial functioning. This scoping review aimed to identify research on the role of neuropsychological functioning in outcomes of vocational rehabilitation programs in individuals with depression.MethodsWe report on the conduct of this pre-registered (https://osf.io/5yrnf) scoping review in accordance with PRISMA-ScR guidelines. PubMed and PsychInfo were systematically searched for English or German research articles published between 1990 and September 2021 that studied objective neuropsychological tests as predictors of vocational rehabilitation interventions and included participants with depression.ResultsThe systematic literature search yielded no studies that specifically targeted subjects with major depression. However, eight articles published since 2016 were included in the review, analyzing data from five trials that evaluated the effectiveness of supported employment in North America and Europe in severe mental illnesses. An estimated 31% of the total number of participants included (n = 3,533) had major depression. Using a variety of cognitive tests and covariates, seven articles found that neuropsychological functioning – especially global cognition scores, verbal and visual learning and memory – significantly predicted vocational outcomes of rehabilitation programs.ConclusionDespite a lack of studies specifically targeting major depressive disorder, the identified literature suggests that higher baseline neuropsychological functioning predicts better vocational outcomes of supported employment programs in individuals with depression. In clinical practice, additional neuropsychological modules during return-to-work interventions might be helpful for vocational outcomes of such programs.
Social distancing and changes in drug use: Results from a cross-sectional study during the COVID-19 pandemic in Brazil
Authors: Nin Maurício Schüler , Heidrich Nubia , Almeida Felipe B. , Izolan Lucas R. , Constant Hilda M. R. M. , Freese Luana , Gomez Rosane , Barros Helena M. T. 
Published: November 2022

BackgroundThe outbreak of coronavirus disease 19 has led to measures of social distancing and quarantine worldwide. This stressful period may lead to psychological problems, including changes in substance use. In addition, sociodemographic factors are linked to changed levels of drug use and abuse observed during the COVID-19 pandemic, which are also associated with increased anxiety, depression, and other disorders. Thus, the aim of the study was to investigate (i) changes in drug use during the COVID-19 pandemic associated with social distancing, and (ii) to verify factors associated with those changes.MethodsA web-based cross-sectional observational survey was completed by a self-selected adult general population in Brazil (N = 2,435) during September/October 2020 (first wave) before and throughout the pandemic. Key outcomes: social distancing, self-reported drug use (ASSIST), and emotional states (DASS-21).ResultsHigh social distancing was associated with fewer chances (prevalence ratio) of increased drug use for alcohol (0.71, CI95%: 0.64–0.80), tobacco (0.72; CI95%: 0.60–0.87), cannabis (0.65; CI95%: 0.55–0.78), and others. Low social distancing presented a higher DASS-21 score for anxiety (P = 0.017). Concerning covariates analysis by a general linear model, men (alcohol: 1. 71; cannabis: 3.86), younger age (alcohol: 0.97), less education (alcohol, tobacco, cannabis and cocaine/crack comparing several lower schooling categories vs. higher education), lower income (alcohol: 0.42; tobacco: 0.47; and cannabis: 0.36), and higher depression DASS-21 score (alcohol: 1.05; tobacco: 1.08; cannabis: 1.07; and cocaine/crack: 1.07) were associated with higher use prevalence of several drugs.ConclusionsIndividuals reporting low social distancing increased the use of most drugs during the pandemic, while high social distancing significantly decreased drug use. Anxiety and depressive states and several sociodemographic factors (men; lower income; less education) were associated with higher drug use patterns.
Cervical cancer survival times in Africa
Authors: Drokow Emmanuel Kwateng , Fangninou Fangnon Firmin , Effah Clement Yaw , Agboyibor Clement , Zhang Yunfeng , Arboh Francisca , Deku Marie-Anne , Xinyin Wu , Wang Yue , Sun Kai 
Published: November 2022

ObjectiveAccessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival. We aimed to perform the first thorough meta-analysis and systematic review of cervical cancer survival times in Africa based on race, histopathology, geographical location and age.Methods and materialsMajor electronic databases were searched for articles published about cervical cancer survival rate in Africa. The eligible studies involved studies which reported 1-year, 3-year or 5-year overall survival (OS), disease-free survival (DFS) and/or locoregional recurrence (LRR) rate of cervical cancer patients living in Africa. Two reviewers independently chose the studies and evaluated the quality of the selected publications, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). We used random effects analysis to pooled the survival rate across studies and heterogeneity was explored via sub-group and meta-regression analyses. A leave-one-out sensitivity analysis was undertaken, as well as the reporting bias assessment. Our findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P).ResultsA total of 16,122 women with cervical cancer were covered in the 45 articles (59 studies), with research sample sizes ranging from 22 to 1,059 (median = 187.5). The five-year overall survival (OS) rate was 40.9% (95% CI: 35.5–46.5%). The five-year OS rate ranged from 3.9% (95% CI: 1.9–8.0%) in Malawi to as high as 76.1% (95% CI: 66.3–83.7%) in Ghana. The five-year disease-free survival rate was 66.2% (95% CI: 44.2–82.8%) while the five-year locoregional rate survival was 57.0% (95% CI: 41.4–88.7%).ConclusionTo enhance cervical cancer survival, geographical and racial group health promotion measures, as well as prospective genetic investigations, are critically required.