bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Efektivitas Penerapan Strategi Pemasaran Dalam Meningkatkan Hunian Kamar Pada Rinjani Hill Hotel di Masa Pandemi Covid 19
Authors: Aryani Menik 
Published: December 2022

Abstract: The purpose of this study was to determine whether the marketing strategy applied to Rinjani Hill Hotel was effective in increasing room occupancy. The method used in this research is descriptive method, and the population is the guests (customers) who stay at Rinjani Hill Hotel. Determination of the sample in the study using the Yamane formula with a precision level of 10% with a confidence level of 90%, so that the results obtained amounted to 83 people. The sampling technique used is purposive sampling and accidental sampling, using library data collection techniques and field studies which include observation, interviews and questionnaires. And to analyze the data obtained is a single table data analysis technique. The results of this study indicate that the marketing strategy applied to Rinjani Hill Hotel has been effective in increasing room occupancy, as evidenced by the number of full rooms and the number of guests staying and the condition of the hotel, rooms and facilities available in accordance with the wishes and needs of guests (customers). . And it was also found that visitors who stay feel like, happy and satisfied with the services of this hotel. Keywords: marketing strategy, Rinjani Hill Hotel, promotion Abstrak: Tujuan penelitian ini adalah untuk mengetahui apakah strategi pemasaran yang diterapkan pada Rinjani Hill Hotel sudah efektif dalam meningkatkan hunian kamar. Metode yang digunakan dalam penelitian ini adalah metode deskriptif, dan yang dijadikan populasi adalah tamu (costumer) yang menginap di Rinjani Hill Hotel. Penentuan sample dalam penelitian menggunakan rumus Yamane dengan tingkat presisi 10% dengan tingkat kepercayaan 90%, sehingga diperoleh hasil berjumlah 83 orang. Teknik penarikan sampel yang digunakan adalah sampling purposif dan sampling kebetulan, dengan menggunakan teknik pengumpulan data kepustakaan dan studi lapangan yang meliputi metode observasi, wawancara dan kuesioner. Serta untuk menganalisis data yang diperoleh adalah dengan teknik analisis data tabel tunggal. Hasil penelitian ini menunjukkan bahwa strategi pemasaran yang diterapkan pada Rinjani Hill Hotel telah efektif dalam menigkatkan hunian kamar, terbukti dari jumlah kamar yang penuh dan banyaknya tamu yang menginap serta kondisi hotel, kamar dan fasilitias yang tersedia telah sesuai dengan keinginan dan kebutuhan tamu (customer). Dan ditemukan juga bahwa pengunjung yang menginap merasa suka, senang dan puas dengan pelayanan hotel ini. Kata kunci: strategi pemasaran, Rinjani Hill Hotel, promosi
PENGEMBANGAN BAHAN AJAR BERBASIS EBOOK PADA PELAJARAN TIK UNTUK SISWA KELAS VII MTs HIDAYATUSSIBYAN NW SANGKERANG
Authors: Hariawan Rudi , Sakti Hadi Gunawan 
Published: December 2022

Abstract: This research is a research on the development of ebook-based teaching materials for Information and Communication Technology (ICT) subjects for grade VII MTs students. Hidayatussibyan NW Sangkerang. The purpose of this study is to help students provide eBook- based teaching materials that are relevant, practical and easy to use for students. This development research method carried out 5 stages of testing, namely: 1) Content Test, 2) Media Test, 3) Design Test, 4) Small Group Test, and 5) Field Test. Based on the results of data analysis, the development of teaching materials based on ICT Subjects for Class VIII uses the Dick & Carey development model whose development process only reaches the ninth stage of development. The results of data analysis concluded that the Development of eBook-Based Teaching Materials for ICT subjects using offline multimedia had a Good (Eligible) qualification. Keywords: e-Book-Based Teaching Materials Abstrak: Penelitian ini adalah penelitian pengembangan bahan ajar berbasis ebook mata pelajaran Teknologi Infromasi dan Komunikasi (TIK) bagi siswa kelas VII MTs. Hidayatussibyan NW Sangkerang. Tujuan penelitian ini adalah untuk memabntu siswa menyediakan bahan ajar berbasis eBook yang relevan, praktis dan mudah digunakan bagi siswa. Metode penelitian pengembangan ini melakukan 5 tahapan uji coba, yaitu: 1) Uji Isi, 2) Uji Media, 3) Uji Desain, 4) Uji Kelompok Kecil, dan 5) Uji Lapangan. Berdasarkan hasil analisis data bahwa pengembangan bahan ajar berbasis eBook Mata Pelajaran TIK Kelas VIII ini menggunakan model pengembangan Dick & Carey yang proses pengembangannya hanya sampai pada tahap kesembilan tahap pengembangan. Hasil analisis data menyimpulkan bahwa Pengembangan Bahan Ajar Berbasis eBook Mata pelajaran TIK menggunakan multimedia offline memiliki kualifikasi Baik (Layak). Kata Kunci : Bahan Ajar Berbasis e-Book
Uso de algoritmos de aprendizaje automático para analizar datos de energía eléctrica facturada. Caso: Chile 2015 – 2021
Authors: Yajure-Ramirez Cesar Aristóteles 
Published: December 2022

En el mercado eléctrico chileno, los usuarios finales se clasifican en clientes libres y clientes regulados. El análisis del consumo energético de los clientes regulados es importante para efectos del diseño y aplicación de las políticas públicas del sector. En esta investigación se hace el análisis de los datos de energía eléctrica facturada mensual de los clientes regulados de Chile, durante el período 2015-2021, con el fin de detectar patrones y predecir la categoría a la que pertenecen. Se utilizan los algoritmos K-Means para la detección de patrones, K-NN para la predicción de la categoría de los clientes, y PCA para determinar las variables más significativas dentro del conjunto de datos. Con K-Means se encontró que los datos se agrupan de acuerdo con el tipo de cliente, con K-NN se obtuvo un modelo que permite predecir a qué tipo de clientes pertenecen los datos, y con PCA se encontró que las variables tipo de cliente, el año y el mes, son las más importantes en el conjunto de datos. Más del 96% de los clientes analizados corresponde al tipo residencial, quienes consumieron el 50% de la energía facturada durante el período de estudio, y además imponen la estacionalidad mensual de los datos. Los resultados obtenidos son de ayuda para el establecimiento y revisión de las políticas aplicadas a los clientes regulados, en cuanto a tarifas, límites de consumo en invierno, y eficiencia energética. Se recomienda continuar la investigación orientándola hacia la predicción del consumo de energía eléctrica.
Análisis del costo de la energía eléctrica en Panamá frente al precio del petróleo
Authors: Vargas-Palma Salvador Elías , Sanfilippo Carlos , García Antony 
Published: December 2022

El costo del petróleo en el mercado internacional tiene un impacto directo sobre los costos de la energía eléctrica. En Panamá existen mecanismos de corrección, de los precios de la energía eléctrica al por menor para compensar estas variaciones a través del factor de corrección por variación combustible (CVC). Este mecanismo permite que la tarifa eléctrica al por menor se ajuste siguiendo las variaciones del petróleo. En el periodo que abarcó de 2015 a 2019, el precio del petróleo fluctuó mucho, llegando a superar los 75 USD por barril y decreciendo por debajo de los 30 USD por barril. Estas fluctuaciones afectaron los costos de energía en Panamá, aunque no precisamente de la manera que se esperaba según las condiciones establecidas para el mercado eléctrico. Para estudiar este fenómeno se ha construido una base de datos con los coeficientes de la tarifa de energía eléctrica y se ha desarrollado una herramienta de software que permite hacer cálculos de la factura por consumo de energía en el periodo de 2015 a 2019, para clientes del grupo de baja tensión sin demanda (BTS). Con la información recogida se realizó un estudio que determinó que existe una correlación moderada entre el costo del petróleo en el mercado internacional y la factura por consumo eléctrico en Panamá de 0.7 y 0.66 para clientes con consumos de 500 kWh (BTS2) y 1000 kWh (BTS3) respectivamente, cuando el CVC se utiliza, y de 0.366 y 0.365 cuando no se utiliza. Igualmente se encuentra que por cada 100 kWh consumidos, la factura se incrementa (o decrementa) en 7.25 centésimos por cada USD de incremento (o decremento) en el precio del barril de petróleo.
Facework strategies and intercultural conflict management procedures between international undergraduates and Malaysian instructors at a private university
Authors: Lin Siew Eng , Tan Dennis Ying Chung , Chang Kuan Lim 
Published: December 2022

Framed by the face negotiation theory and intercultural conflict management concepts, this study aims to identify the facework strategies used by international undergraduates in intercultural conflicts with Malaysian instructors at a private university, and investigate the preferred effective conflict management procedures for Malaysian instructors in managing intercultural conflicts with international undergraduates. This study uses a descriptive cross-sectional design using questionnaires for data collection. A total of 317 participants were involved: 105 Indonesian undergraduates, 106 Chinese undergraduates, and 106 Malaysian instructors. The results showed that both Indonesian and Chinese undergraduate groups have similar tendencies for integrating strategies, although they differ in avoiding and dominating strategies. For intercultural conflict management procedures, the most favourable procedure is mediation and the least favourable is ombudsman service. These findings provide instructors with first-hand data for subsequent teacher development on face-saving application. By applying the appropriate facework strategy and ways to enact it, instructors can further develop their teaching skills by creating a healthy student-teacher relationship with international students.
Investigating the impact of pre-slaughter management factors on meat quality outcomes in cattle raised for beef: A scoping review
Authors: Sullivan Paxton , Davis Melissa , Bretón Jimena , Edwards-Callaway Lily 
Published: December 2022

IntroductionThe pre-slaughter management period is a critical juncture in the beef supply chain, having implications not only for animal welfare and product quality, but also for profitability. During this period, cattle are exposed to many stressors in a short time, many of which have been shown to impact meat quality. Understanding how cattle management during this terminal step in the production chain affects meat quality and economic outcomes is crucial.MethodsThe objective of this study was to investigate, synthesize, and report on research evaluating the impact of management factors during the pre-slaughter period on beef meat quality. A systematic approach was used to search for peer-reviewed and primary studies published in English in CAB Abstracts, PubMed, and Web of Science. A total of 3,217 non-duplicate records were screened for eligibility; articles were deemed eligible for inclusion if they included beef cattle in the pre-slaughter period and reported at least one meat quality outcome. After three screening rounds, 85 articles met all inclusion criteria. Data pertinent to the scoping review’s aims were extracted, including study location, population characteristics, pre-slaughter factors reported, and outcomes of interest.ResultsEurope (35, 41%) and South America (21, 25%) represented approximately two-thirds of the studies. Bulls (37, 43.5%) and steers (34, 40.0%) were the most reported sex classes, with the most frequent breed types reported as predominantly British or Continental and Bos indicus breeds (24, 28.2%; 24, 28.2%, respectively). Transportation (n=46), lairage (n=36), and handling (n=35) practices were the most reported pre-slaughter factors. Overall, 59 studies reported pH as an outcome of interest – almost double that of the next highest outcome, bruising (n=35). Muscle pH was most assessed with predictors at the abattoir (n=37); conversely, the effects of transportation were most evaluated on bruising (n=23).DiscussionA trend across all the categories was that there were relatively few studies evaluating the impact of pre-transport factors on meat quality. Charting the relevant literature is a critical step towards understanding the relationship between pre-slaughter management and end-product quality; doing so will help industry stakeholders in the beef production chain optimize management practices that improve meat quality and enhance profitability.
Evaluating cell viability, capillary perfusion, and collateral tortuosity in an ex vivo mouse intestine fluidics model
Authors: Willi Caroline E. , Abdelazim Hanaa , Chappell John C. 
Published: December 2022

Numerous disease conditions involve the sudden or progressive loss of blood flow. Perfusion restoration is vital for returning affected organs to full health. While a range of clinical interventions can successfully restore flow to downstream tissues, the microvascular responses after a loss-of-flow event can vary over time and may involve substantial microvessel instability. Increased insight into perfusion-mediated capillary stability and access-to-flow is therefore essential for advancing therapeutic reperfusion strategies and improving patient outcomes. To that end, we developed a tissue-based microvascular fluidics model to better understand (i) microvascular stability and access-to-flow over an acute time course post-ischemia, and (ii) collateral flow in vessels neighboring an occlusion site. We utilized murine intestinal tissue regions by catheterizing a feeder artery and introducing perfusate at physiologically comparable flow-rates. The cannulated vessel as well as a portion of the downstream vessels and associated intestinal tissue were cultured while constant perfusion conditions were maintained. An occlusion was introduced in a selected arterial segment, and changes in perfusion within areas receiving varying degrees of collateral flow were observed over time. To observe the microvascular response to perfusion changes, we incorporated (i) tissues harboring cell-reporter constructs, specifically Ng2-DsRed labeling of intestinal pericytes, and (ii) different types of fluorescent perfusates to quantify capillary access-to-flow at discrete time points. In our model, we found that perfusion tracers could enter capillaries within regions downstream of an occlusion upon the initial introduction of perfusion, but at 24 h tissue perfusion was severely decreased. However, live/dead cell discrimination revealed that the tissue overall did not experience significant cell death, including that of microvascular pericytes, even after 48 h. Our findings suggest that altered flow conditions may rapidly initiate cellular responses that reduce capillary access-to-flow, even in the absence of cellular deterioration or hypoxia. Overall, this ex vivo tissue-based microfluidics model may serve as a platform upon which a variety of follow-on studies may be conducted. It will thus enhance our understanding of microvessel stability and access-to-flow during an occlusive event and the role of collateral flow during normal and disrupted perfusion.
Reduced macula microvascular densities may be an early indicator for diabetic peripheral neuropathy
Authors: Deng Xiaoyu , Wang Shiqi , Yang Yan , Chen Aizhen , Lu Jinger , Hao Jinkui , Wu Yufei , Lu Qinkang 
Published: December 2022

Purpose: To assess the alteration in the macular microvascular in type 2 diabetic patients with peripheral neuropathy (DPN) and without peripheral neuropathy (NDPN) by optical coherence tomography angiography (OCTA) and explore the correlation between retinal microvascular abnormalities and DPN disease.Methods: Twenty-seven healthy controls (42 eyes), 36 NDPN patients (62 eyes), and 27 DPN patients (40 eyes) were included. OCTA was used to image the macula in the superficial vascular complex (SVC) and deep vascular complex (DVC). In addition, a state-of-the-art deep learning method was employed to quantify the microvasculature of the two capillary plexuses in all participants using vascular length density (VLD).Results: Compared with the healthy control group, the average VLD values of patients with DPN in SVC (p = 0.010) and DVC (p = 0.011) were significantly lower. Compared with NDPN, DPN patients showed significantly reduced VLD values in the SVC (p = 0.006) and DVC (p = 0.001). Also, DPN patients showed lower VLD values (p &lt; 0.05) in the nasal, superior, temporal and inferior sectors of the inner ring of the SVC when compared with controls; VLD values in NDPN patients were lower in the nasal section of the inner ring of SVC (p &lt; 0.05) compared with healthy controls. VLD values in the DVC (AUC = 0.736, p &lt; 0.001) of the DPN group showed a higher ability to discriminate microvascular damage when compared with NDPN.Conclusion: OCTA based on deep learning could be potentially used in clinical practice as a new indicator in the early diagnosis of DM with and without DPN.
A comprehensive description of the TolC effect on the antimicrobial susceptibility profile in Enterobacter bugandensis
Authors: Li Bingyu , Zhang Ji , Li Xiaodong 
Published: December 2022

BackgroundEnterobacter bugandensis is an emerging human pathogen in which multidrug resistant strains have been continuously isolated from various environments. Thus, this organism possesses the potential to pose challenges in human healthcare. However, the mechanisms, especially the efflux pumps, responsible for the multidrug resistance in E. bugandensis remain to be well elucidated.MethodsThe Enterobacter strain CMCC(B) 45301 was specifically identified using whole genome sequencing. The specific CMCC(B) 45301 homologues of the TolC dependent efflux-pump genes characterized in Escherichia coli were identified. The tolC deletion mutant in CMCC(B) 45301 was constructed and subjected to susceptibility tests using 26 different antimicrobial agents, along with the wild type strain. The synergistic effects combining the Bacillus crude extract (BCE) and several other TolC-affected compounds against CMCC(B) 45301 were assayed.ResultsWe reclassified the Enterobacter CMCC(B) 45301 strain from species cloacae to bugandensis, on the basis of its whole genome sequence. We found that the CMCC(B) 45301 TolC, AcrAB, AcrD, AcrEF, MdtABC, EmrAB, and MacAB exhibit high similarity with their respective homologues in E. coli and Enterobacter cloacae. Our results for the susceptibility tests revealed that lacking tolC causes 4- to 256-fold decrease in the minimal inhibitory concentrations of piperacillin, gentamicin, kanamycin, tetracycline, norfloxacin, ciprofloxacin, chloramphenicol, and erythromycin against CMCC(B) 45301. In addition, the inhibition zones formed by cefuroxime, cefoperazone, amikacin, streptomycin, minocycline, doxycycline, levofloxacin, florfenicol, trimethoprim-sulfamethoxazole, azithromycin, lincomycin, and clindamycin for the tolC mutant were larger or more obvious than that for the parent. Our data suggested the important role played by TolC in CMCC(B) 45301 susceptibility to common antibiotic families covering ß-lactam, aminoglycoside, tetracycline, fluoroquinolone, phenicol, folate pathway antagonist, macrolide, and lincosamide. Deletion for tolC also increased the susceptibility of CMCC(B) 45301 to berberine hydrochloride and BCE, two natural product-based agents. Finally, we found that erythromycin, norfloxacin, and ciprofloxacin can potentiate the antibacterial activity of BCE against CMCC(B) 45301.DiscussionThe present study elaborated the comprehensive TolC effect on the antimicrobial susceptibility profile in E. bugandensis, which might contribute to the development of more therapeutic options against this nosocomial pathogen.
A visualized dynamic prediction model for survival of patients with geriatric thyroid cancer: A population-based study
Authors: Zhang Ting-ting , Zeng Jing , Yang Yan , Wang Jin-jing , Kang Yao-jie , Zhang Dong-he , Liu Xiao-zhu , Chen Kang , Wang Xuan , Fang Yi 
Published: December 2022

ObjectiveThyroid cancer (TC) is a common malignancy with a poor prognosis with aging. However, no accurate predictive survival model exists for patients with geriatric TC.We aimed to establish prediction models of prognosis in elderly TC.MethodsWe retrospectively reviewed the clinicopathology characteristics of patients with geriatric TC in the Surveillance, Epidemiology, and End Results database (SEER) from 2004 to 2018. The risk predictors used to build the nomograms were derived from the Cox proportional risk regression. These nomograms were used to predict 1-, 3-, and 5-year overall survival and cancer-specific survival in elderly patients with TC. The accuracy and discriminability of the new model were evaluated by the consistency index (C-index) and calibration curve. The clinical applicability value of the model was assessed using the decision curve analysis.ResultsWe used the SEER database to include 16475 patients with geriatric TC diagnosed from 2004 to 2018. The patients from 2004 to 2015 were randomly sorted out on a scale of 7:3. They were classified into a training group (n = 8623) and a validation group (n = 3669). Patients with TC diagnosed in 2016–2018 were classified into external validation groups (n = 4183). The overall survival nomogram consisted of 10 variables (age, gender, marital status, histologic type, grade, TNM stage, surgery status, and tumor size). A cancer-specific survival nomogram consisted of eight factors (age, tumor size, grade, histologic type, surgery, and TNM stage). The C-index values for the training, validation, and external validation groups were 0.775 (95% confidence interval [CI] 0.785–0.765), 0.776 (95% CI 0.792–0.760), and 0.895(95% CI 0.873–0.917), respectively. The overall survival was consistent with a nomogram based on the calibration curve. Besides, the decision curve analysis showed excellent clinical application value of the nomogram. Additionally, we found that surgery could improve the prognosis of patients with geriatric at high-risk (P &lt; 0.001) but not those at low-risk (P = 0.069).ConclusionThis was the first study to construct predictive survival nomograms for patients with geriatric TC. The well-established nomograms and the actual results could guide follow-up management strategies.
Semaglutide ameliorates metabolism and hepatic outcomes in an NAFLD mouse model
Authors: Niu Shu , Chen Shuchun , Chen Xing , Ren Qingjuan , Yue Lin , Pan Xiaoyu , Zhao Huiying , Li Zelin , Chen Xiaoyi 
Published: December 2022

PurposeThe aim of this study was to evaluate changes in body weight, liver weight, blood glucose, liver injury markers, pro-inflammatory factors and oxidative stress marker levels in obese mice with HFD induced NAFLD after semaglutide use.Patients and methodsThe 24 C57BL6J mice were randomly divided into three groups (NCD, HFD and Sema) for the assessment of metabolic status, inflammatory factor and oxidative stress marker levels, liver histopathology in mice. Liver metabolomics was determined by liquid chromatography/mass spectrometry (LC-MS) method.ResultsThe mice body weight, liver weight, blood glucose, TG, TCHO, LDL and pro-inflammatory factors were significantly reduced after semaglutide. Meanwhile, semaglutide increased the SOD level. Semaglutide treatment significantly improved the pathological changes such as hepatocyte steatosis, balloon degeneration and lymphoid foci by HE. It also significantly reduced lipid droplet by Oil Red O. The mitochondria were swollen, the volume increased, the cristae were partially broken and reduced, the intramembrane matrix was partially dissolved, and the mitophagy structure was visible in the visual field. There were 6 metabolites down-regulated and 2 metabolites significantly up-regulated after semaglutide treatment.ConclusionsSemaglutide can reduce blood glucose level and liver fat accumulation and play an anti-inflammatory role in advanced NAFLD that due to the effects of HFD.