bluuebunny/crossref_metadata_2025_split huggingface dataset:
Processing and properties of hafnium‐doped tin‐modified lead zirconate titanate 95/5 ceramics
Authors: Neuman Eric W. , Anselmo Nicholas , Meyer Amber , Diantonio Christopher B. , Rodriguez Mark A. , Torres Rose M. , Brane Brian K. , Griego James G. 
Published: April 2022

AbstractNiobium (Nb)‐doped lead‐tin‐zirconate‐titanate (PSZT) ceramics near the lead‐zirconate‐titanate 95/5 orthorhombic AFE‐rhombohedral FE morphotropic phase boundary (PSZT 13.5/81/5.5 ‐1.6Nb) were prepared with up to 10 mol.% of hafnium (Hf) substituted for zirconium. The ceramics were prepared by a traditional solid‐state synthesis route and sintered to near full density at 1150°C for 6 h in sealed alumina crucibles with self‐same material as the lead vapor source. All compositions were ∼98% dense with no detectable secondary phases by X‐ray diffraction. The grain size was ∼3 μm for all compositions, consisting of equiaxed grains with intergranular porosity. The compositions exhibited remnant polarization values of ∼32 μC/cm2. Depolarization by the hydrostatic pressure‐induced FE‐AFE phase transition occurred at 310 MPa for all compositions, resulting in a total depolarization output of 32.4 μC/cm2 for the PSZT ceramics. Evaluation of the R3c‐R3m and R3m‐Pm m phase transition temperatures by impedance spectroscopy showed temperatures on heating ranging from 86 to 92°C and 186 to 182°C, respectively, for increasing nominal Hf content. Thermal hysteresis of the phase transitions was also observed in the ceramics, with the transition temperature on cooling being 1–4°C lower. The study demonstrated that the PSZT ceramics are relatively insensitive to variations in Hf content in the range of 0 to 10 mol.%.
Inactivation of Competitive Decay Channels Leads to Enhanced Coumarin Photochemistry
Authors: Klimek Robin , Asido Marvin , Hermanns Volker , Junek Stephan , Wachtveitl Josef , Heckel Alexander 
Published: April 2022

AbstractIn the development of photolabile protecting groups, it is of high interest to selectively modify photochemical properties with structural changes as simple as possible. In this work, knowledge of fluorophore optimization was adopted and used to design new coumarin‐ based photocages. Photolysis efficiency was selectively modulated by inactivating competitive decay channels, such as twisted intramolecular charge transfer (TICT) or hydrogen‐bonding, and the photolytic release of the neurotransmitter serotonin was demonstrated. Structural modifications inspired by the fluorophore ATTO 390 led to a significant increase in the uncaging cross section that can be further improved by the simple addition of a double bond. Ultrafast transient absorption spectroscopy gave insights into the underlying solvent‐dependent photophysical dynamics. The chromophores presented here are excellently suited as new photocages in the visible wavelength range due to their simple synthesis and their superior photochemical properties.
Chiral Hemilabile P,N‐Ligand‐Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation
Authors: Ye Xiaohan , Wang Chenhuan , Zhang Shuyao , Tang Qi , Wojtas Lukasz , Li Minyong , Shi Xiaodong 
Published: April 2022

AbstractEnantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N ligands as the optimal choice, giving alkene aminoarylation with good yields (up to 80 %) and excellent stereoselectivity (up to 99 : 1 er). As the first example of enantioselective gold redox catalysis, this work confirmed the feasibility of applying a chiral ligand at the gold(I) stage, with the stereodetermining step (SDS) at the gold(III) intermediate, thus opening up a new way to conduct gold redox catalysis with stereochemistry control.
Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor‐α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects
Authors: Huang Kai , Chu Nannan , Ding Ying , Que Linglin , Qian Zhenzhong , Shi Yunfei , Qin Wei , He Qing 
Published: April 2022

AbstractThis study aimed to compare the pharmacokinetics, safety, and immunogenicity of the prefilled syringe (PFS) with lyophilized (LYO) recombinant human tumor necrosis factor‐α receptor II:lgG Fc fusion protein (rhTNFR:Fc) in healthy Chinese male subjects. A single‐center, randomized, open‐label, 2‐period, crossover study was performed in healthy Chinese male subjects. Subjects were randomly assigned into 2 sequences and received a subcutaneous injection of 25 mg rhTNFR:Fc PFS or rhTNFR:Fc LYO (Anbainuo), with a 35‐day washout between the 2 periods. Blood samples were collected at specified time intervals, and then serum concentrations of rhTNFR:Fc were analyzed by enzyme‐linked immunosorbent assay. The maximum serum concentration, area under the concentration‐time curve (AUC) from time 0 to the last quantifiable concentration, and AUC from time 0 to infinity were all calculated and evaluated. Meanwhile, safety and immunogenicity were also assessed. A total of 82 subjects completed the study, and six subjects withdrew for various reasons. The 90%CIs for geometric mean ratios of maximum serum concentration, AUC from time 0 to the last quantifiable concentration, and AUC from time 0 to infinity were all within the equivalence range of 80% to 125%. Safety was comparable between the 2 formulations with low immunogenicity. rhTNFR:Fc PFS exhibited similar pharmacokinetic and safety profiles of rhTNFR:Fc LYO (Anbainuo) in healthy Chinese male subjects.
Bone remodeling around dental implants after 1–1.5 years of functional loading: A retrospective analysis of two‐stage implants
Authors: Maghsoudi Poyan , Slot Dagmar E. , van der Weijden Fridus (G. A.) 
Published: April 2022

AbstractObjectivesThis study aims to retrospectively assess to what extent peri‐implant bone level changes occur from exposing the implant to the oral environment at the second stage of surgery (SSS) to the baseline assessment and, additionally, after 1–1.5 years of functional loading. Further, this study aims to examine the role of the emergence angle in marginal bone changes.Material and MethodsThis retrospective study included 46 patients treated between 2012 and 2019. These patients received 64 bone‐level dental implants. After implant placement, SSS, and baseline assessment, relevant clinical peri‐implant conditions and radiographical data were collected. A radiographic examination of the marginal bone level was performed after SSS, the baseline assessment, and 1–1.5 years of follow‐up.ResultsThe peri‐implant periodontal probing depth increased significantly from 3.08 ± 0.7 mm at the baseline to 3.27 ± 0.81 mm at the 1–1.5‐year follow‐up. The mean marginal bone level at the implant level was 0.12 ± 0.23, 0.35 ± 0.43, and 0.47 ± 0.47 mm at the SSS, baseline, and the 1–1.5‐year follow‐up, respectively. Most changes occurred at the implant's distal site. A significant relationship was found between the emergence angle and the extent of change in the marginal bone level between the SSS and baseline (r = .430, p ≤ .001).ConclusionsMost changes in the marginal bone level occurred between SSS and baseline assessments. For diagnostic purposes, it is advised to obtain a standardized radiograph after SSS to monitor peri‐implant bone‐level alterations.
RETRACTED: Conciliation procedures in civil proceedings: Comparative legal aspect
Authors: Zhumayeva Mariya S. , Kassenova Aigul Zh. , Zhailin Gabiden A. , Tlegenova Fatima A. , Akhmetov Zhassulan M. 
Published: April 2022

AbstractNowadays, the system of judicial settlement of disputes by means of conciliation correlates with the rule of law, has fundamental disagreements with extrajudicial and, accordingly, less formal instruments for resolving disputes—mediation, negotiations. Moreover, the advantage of the judicial conciliation procedure lies in the ability to ensure the implementation of the decision and its compliance with generally accepted values, and the interpretation of legal provisions is the business of officially authorized officials, and not specialists who act privately. The purpose of the paper is to conduct a comparative analysis of the legal regulation of approbation of conciliation procedures in civil proceedings. In the process of writing the paper, scientific and legal approaches to the essence of the procedure for conciliation in civil proceedings were identified; a comparative legal analysis of the specific features of legal regulation of conciliation procedures in civil proceedings in the territory of the European Union and in the post‐Soviet space was carried out; the prospects for improving the investigated procedure were outlined. It can be concluded that the comparative study of the foundations of legal regulation of conciliation procedures in civil proceedings in the territory of the European Union and in the post‐Soviet space showed the flexibility of the procedure under study, the multivariance of approaches to its implementation, and unity in supporting this method of resolving disputes.
Non‐contact detection of fentanyl by a field‐portable ion mobility spectrometer
Authors: Fulton Ashley C. , Vaughan Stephanie R. , DeGreeff Lauryn E. 
Published: April 2022

AbstractRapid on‐site detection of fentanyl is paramount for the safety of law enforcement and other first responders. Due to the opioid epidemic, death by overdose is at an all‐time high with fentanyl adulteration as the main assailant. Providing a user‐friendly method for the presumptive detection of fentanyl will increase safety for first responders. Ion mobility spectrometry (IMS) provides a quick, affordable, and accurate method for detecting fentanyl. Currently, most methods for detecting fentanyl require manipulation or handling of the highly potent substance. A recent comparative analysis study on the headspace of fentanyl determined N‐phenylpropanamide (NPPA) a target analyte for fentanyl enabling vapor detection. Here, we demonstrate the development of a handheld IMS method for vapor detection of the target analyte for fentanyl. An alarm was programmed into the handheld IMS device for the detection of NPPA. The system was able to accurately detect NPPA in samples of reference‐grade fentanyl and diluted reference‐grade fentanyl, as well as 3.67 mg of fentanyl from samples confiscated from the US border. Common adulterants and over‐the‐counter drugs were tested and resulted in a false alarm rate of 0 for substances sampled. The limit of detection was determined to be as low as 5 ng of NPPA. Overall, the development of this user‐friendly, non‐contact method has considerable promise for near real‐time non‐contact detection of fentanyl increasing safety of first responders.
Anti‐IFN‐α/‐ω neutralizing antibodies from COVID‐19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity
Authors: Frasca Federica , Scordio Mirko , Santinelli Letizia , Gabriele Lucia , Gandini Orietta , Criniti Anna , Pierangeli Alessandra , Angeloni Antonio , Mastroianni Claudio M. , d'Ettorre Gabriella , Viscidi Raphael P. , Antonelli Guido , Scagnolari Carolina 
Published: April 2022

AbstractA significant number of COVID‐19 patients were shown to have neutralizing antibodies (NAB) against IFN; however, NAB specificity, fluctuation over time, associations with biochemical and hematological parameters, and IFN gene expression are not well characterized.Binding antibodies (BAB) to IFN‐α/‐β were screened in COVID‐19 patients’ serum. All BAB positive sera, and a subset of respiratory samples, were tested for NAB against IFN‐α/‐β/‐ω, using an antiviral bioassay. Transcript levels of IFN‐α/‐β/‐ω and IFN‐stimulated genes (ISGs) were quantified.Anti‐IFN‐I BAB were found in 61 out of 360 (17%) of patients. Among BAB positive sera, 21.3% had a high NAB titer against IFN‐α. A total of 69.2% of anti‐IFN‐α NAB sera displayed cross‐reactivity to IFN‐ω. Anti‐IFN‐I NAB persisted in all patients. NAB to IFN‐α were also detected in 3 out of 17 (17.6%) of respiratory samples. Anti‐IFN‐I NAB were higher in males (p = 0.0017), patients admitted to the ICU (p < 0.0001), and patients with a fatal outcome (p < 0.0001). NAB were associated with higher levels of CRP, LDH, d‐Dimer, and higher counts of hematological parameters. ISG‐mRNAs were reduced in patients with persistently NAB titer.NAB are detected in a significant proportion of severe COVID‐19. NAB positive patients presented a defective IFN response and increased levels of laboratory biomarkers of disease severity.
Light as a Tool in Organic Photocatalysis: Multi‐Photon Excitation and Chromoselective Reactions
Authors: Markushyna Yevheniia , Savateev Aleksandr 
Published: April 2022

AbstractOver the past decades, photoredox catalysis has developed to the big mature field of chemistry. Especially in the field of organic synthesis, more and more sustainable alternatives to conventional synthesis are being developed. Nonetheless, most research activities are focused on the development of new synthetic pathways, utilizing photons as a source of energy for breaking and building of new chemical bonds. We discuss here cases, where selection of the irradiation mode, light intensity (one‐, two‐ photons) or wavelength (UV, blue, green) has a crucial role on the outcome of the photocatalytic event. Thus, control over irradiation conditions influence the reaction mechanism and offers an access to highly reactive species that are otherwise hardly available. This allows for the unique chemical events to happen, such as deep reduction reactions. The principles of these concepts and their applications are reviewed for both homogeneous and heterogeneous photocatalysts.
Copper‐Catalyzed Ring‐Opening (3+2) Annulation of Cyclopropenones with Ketoxime Acetates: Access to 1,2‐Dihydro‐pyrrol‐3‐ones Bearing a Quaternary Carbon Center
Authors: Wang Zhen‐Hua , Yang Ping , Zhang Yan‐Ping , You Yong , Zhao Jian‐Qiang , Zhou Ming‐Qiang , Yuan Wei‐Cheng 
Published: April 2022

AbstractA Cu(I)‐catalyzed ring‐opening (3+2) annulation of cyclopropenones with ketoxime acetates has been developed. In disclosed protocol, ketoxime acetates are selected as C−N splicing unit to participate in the transformation process, furnishing a sequence of highly functional 1,2‐dihydro‐pyrrol‐3‐one derivatives in good isolated yields. Besides, scale‐up reaction is conducted to demonstrate the practicability of developed methodology and a tentative mechanism for (3+2) annulation is also proposed.
KI/K2S2O8 Mediated Cascade C(sp3)−H/C(sp2)−H Thiolation for the Synthesis of Multi‐Substituted Thiazoles
Authors: Liu Lang , Zhang Jun 
Published: April 2022

AbstractThiazole and carbonyl often act as core functional or regulative moieties in biological molecules as well as optical materials. Designing and synthesis of carbonyl‐containing thiazoles are of great importance for related fields, hence, a simple and practical method was developed using commercially xanthates, benzylamine, and readily available alkynones as substrates. The reaction was achieved using one‐pot Michael addition and cascade iodine mediated C−H thiolation under mild conditions. This method features a broad substrate scope with high yield. Remarkably, the obtained carbonyl substituted thiazoles bearing electronic‐donating substituents exhibit promising performance for aggregation‐induced emission (AIE) and have been successfully used in biological imaging.
Visible Light‐Promoted, Photocatalyst‐Free C(sp2)−H Bond Functionalization of Indolizines via EDA Complexes
Authors: Mane Kishor D. , Rupanawar Bapurao D. , Suryavanshi Gurunath 
Published: April 2022

AbstractThe catalyst and additive‐free, photo‐driven cross dehydrogenative coupling (CDC) reaction initiated by electron donor‐acceptor (EDA) complexes between electron rich indolizines and electron poor quinones has been demonstrated. This green transformation reveals the advantages of operational simplicity, mild reaction conditions and good functional group tolerances.
Catalyst‐ and Oxidant‐Free Electrochemical Halogenation Reactions of 2H‐Indazoles with NaX (X=Cl, Br)
Authors: Liu Xin , Wu Zengzhi , Feng Chenglong , Liu Wenlu , Li Meichao , Shen Zhenlu 
Published: April 2022

AbstractAn environmentally friendly and highly efficient electrochemical method has been developed for halogenation of 2H‐indazoles with cheap and commercially available NaX (X=Cl, Br) in the absence of metal catalysts and oxidants. Notably, this electrochemical process exhibits a broad substrate scope and high functional‐group compatibility. A variety of 2H‐indazoles are compatible with this transformation to give the corresponding products in modern to excellent yields. Also, this practical protocol avoids using external expensive supporting electrolytes. Last but not least, the procedure was carried out in an undivided cell at constant current condition under air atmosphere.
Enhanced capture of benzothiophene with a magnetism‐bimetallic Fe3O4@Zn/Cu‐BTC composite
Authors: Zhang Shiya , Zhu Yingzhi , Ma Na , Dai Wei 
Published: April 2022

AbstractSince benzothiophene (BT) is a typical S‐containing compound in commercial fuels, proper adsorbents with desirable BT capture ability need to be developed. A novel magnetism‐bimetallic Fe3O4@Zn/Cu‐BTC composite has been synthesized via a simple one‐pot method for the removal of BT from mixed model fuel. SEM, XRD, XPS, and BET characterizations described the as‐prepared Fe3O4@Zn/Cu‐BTC. BT uptakes over Fe3O4@Zn/Cu‐BTC reached 85 mg/g, which is superior to those of previously reported in literature. Batch adsorption studies revealed that the adsorption process obeyed pseudo‐second order kinetic model, the determining step might be chemical sorption, and adsorption equilibrium could be achieved within 30 min. Among various isotherm models, the experimental data for adsorption of BT followed the Langmuir isotherm best. Thermodynamic parameters demonstrated that BT adsorption process was endothermic and spontaneous. Importantly, Fe3O4@Zn/Cu‐BTC could be easy obtained from liquid through Fe3O4 magnetism, and has high stability and good reusability, which might be beneficial for further practical deep desulfurization.
Neural mechanisms of the mood effects on third‐party responses to injustice after unfair experiences
Authors: Xie Enhui , Liu Mengdie , Liu Jieqiong , Gao Xiaoxue , Li Xianchun 
Published: April 2022

AbstractBehavioral decision theory argues that humans can adjust their third‐party responses (e.g., punishment and compensation) to injustice by integrating unfair experiences. Typically, the mood plays an important role in such a decision‐making process. However, the underlying neurocognitive bases remain largely unclear. We first employ a modified third‐party justice game in which an allocator split an amount of money between oneself and a receiver. The participants can reapportion the money as observers by choosing from the following three costly options: compensate the receiver, accept the current allocation, or punish the allocator. Then, a second‐party pseudo interaction is conducted where participants receive more (i.e., advantageous unfair experience) or less (i.e., disadvantageous unfair experience) than others. Finally, participants perform the third‐party justice game again after unfair experiences. Here, we use functional near‐infrared spectroscopy (fNIRS) to measure participants' brain activities during third‐party responses to injustice. We find participants compensate more to the receiver after advantageous unfair experience, which involved enhanced positive emotion, weakened sense of unfairness, and is linked with increased activity in the right dorsolateral prefrontal cortex (rDLPFC). In contrast, participants punish more on the allocator after disadvantageous unfair experience, which might primarily stem from their negative emotional responses, strong sense of unfairness, and is associated with significantly decreased activity in the rDLPFC. Our results suggest that third‐party compensation and punishment involved differential psychological and neural bases. Our findings highlight the crucial roles of second‐party unfair experiences and the corresponding mood responses in third‐party responses to unfairness, and unravel the intermediate neural architecture.
Accelerated longitudinal cortical atrophy in OEF/OIF/OND veterans with severe PTSD and the impact of comorbid TBI
Authors: Brown Emma M. , Salat David H. , Milberg William P. , Fortier Catherine B. , McGlinchey Regina E. 
Published: April 2022

AbstractVeterans who deployed in support of Operation Enduring Freedom (OEF), Iraqi Freedom (OIF), and New Dawn (OND) commonly experience severe psychological trauma, often accompanied by physical brain trauma resulting in mild traumatic brain injury (mTBI). Prior studies of individuals with posttraumatic stress disorder (PTSD) have revealed alterations in brain structure, accelerated cellular aging, and impacts on cognition following exposure to severe psychological trauma and potential interactive effects of military‐related mTBI. To date, however, little is known how such deployment‐related trauma changes with time and age of injury of the affected veteran. In this study, we explored changes in cortical thickness, volume, and surface area after an average interval of approximately 2 years in a cohort of 254 OEF/OIF/OND Veterans ranging in age from 19 to 67 years. Whole‐brain vertex‐wise analyses revealed that veterans who met criteria for severe PTSD (Clinician‐Administered PTSD Scale ≥60) at baseline showed greater negative longitudinal changes in cortical thickness, volume, and area over time. Analyses also revealed a significant severe‐PTSD by age interaction on cortical measures with severe‐PTSD individuals exhibiting accelerated cortical degeneration with increasing age. Interaction effects of comorbid military‐related mTBI within the severe‐PTSD group were also observed in several cortical regions. These results suggest that those exhibiting severe PTSD symptomatology have accelerated atrophy that is exacerbated with increasing age and history of mTBI.