bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Australian policies enable a primary health care system to identify family adversity and subsequently support these families—A scoping study
Authors: Honisett Suzy , Loftus Hayley , Liu HueiMing , Montgomery Alicia , De Souza Denise , Hall Teresa , Eastwood John , Hiscock Harriet , Goldfeld Sharon 
Published: November 2022

AbstractIssue AddressedTo determine if Australian policies support a primary health care system to identify family adversity and subsequently support these families.MethodsTwo methodological approaches were used: (i) a scoping review of Australian federal and two states (Victoria and New South Wales) policies related to family adversity (e.g., childhood maltreatment or household dysfunction, such as parental mental illness); (ii) thirteen semi‐structured interviews with Victorian Community Health Service (CHS) staff and government policy makers, recruited via snowball sampling to understand the context of policy making and service implementation. Data collected were subsequently discussed in relation to the Stages Model of policy analysis.ResultsOne hundred and eighty‐eight policies referenced family adversity. Of these, 37 policies met all eligibility criteria including a focus on early intervention within primary care and were included in the review. Most policies were developed within health departments (78%) and included a wide range of adversities, with the majority based within maternal and child health and CHS platforms. Most policy development included consultation with stakeholders. Although most policies received some level of funding, few included funding details and only a third included evaluation.ConclusionsThere are many policies related to family adversity in Australia, with most focused within existing primary care platforms. Given these policies, Australia should be well positioned to identify and respond to family adversity.So WhatMore work needs to be done to ensure policies are adequately implemented, evaluated and transparently and appropriately funded. The co‐occurrence of adversity should focus policy action; and potentially lead to more effective and efficient outcomes.
The heterogeneity of public preferences for the first healthcare visit: A discrete choice experiment in the context of Vietnam
Authors: Nguyen Hieu Thi Thanh , Vo Trung Quang , Tran Hien Thi Bich , Nguyen Binh Thanh , Nguyen Hiep Thanh , Nguyen Thoai Dang , Anuratpanich Luerat 
Published: November 2022

AbstractPrimary healthcare is critical in addressing the main health problems of communities. In Vietnam, the increasing healthcare demands cause major challenges, especially overcrowding. This study identified public preferences regarding the selection of healthcare facilities for first visit. A discrete choice online survey was generated from five attributes including visit duration, travel time, personal connection with medical staff, doctors' experience, and health insurance. A Dz‐efficient design constructed 36 choice sets, divided into three blocks of 12 choice sets. Each block formed one version of the questionnaire, which was randomly distributed to the participants. Heterogeneity in participant preferences was analysed by a latent class model with socio demographic characteristics and experiences of the last visit. 822 participants valued doctors' experience for both minor and severe symptoms. Preference heterogeneity for minor symptoms was quick service provision, highly experienced doctors, and payment through health insurance for the first (44.18%), second (32.17%), and third classes (23.66%), respectively. Regarding severe symptoms, they favoured all five attributes, quick health service, and reduced travel time for the first, second, and third classes, respectively (heterogeneities of 58.16%, 27.79%, and 14.05%, respectively). Predictions of choice from the worst to optimal healthcare facility scenario were 8.91%–61.91% and 10.16%–69.83% for minor and severe symptoms, respectively. Knowledge regarding public preference heterogeneity supports policymakers increase public acceptance in choosing primary healthcare facilities. Visit duration and doctors' experience should be considered a priority in decision making.
Coefficient of R‐R interval variations under deep breathing load in patients with wild‐type transthyretin amyloid cardiomyopathy: A case‐control study
Authors: Nagayoshi Yasuhiro , Kawano Hiroaki , Nishihara Taiki , Morikawa Kei , Nagano Haruka , Hanatani Shinsuke , Sakaino Naritsugu , Tsujita Kenichi 
Published: November 2022

AbstractBackground and AimsAn autonomic nervous disorder is an important characteristic of cardiac amyloidosis; however, the prevalence of autonomic dysfunction in wild‐type transthyretin amyloidosis (ATTRwt) has not been established. Analysis of the R‐R interval coefficient of variation (CVR‐R) is a noninvasive method to measure parasympathetic activity. We aimed to assess autonomic dysfunction of ATTRwt and determine the utility of CVR‐R for the detection of ATTRwt in other cardiac diseases.MethodsThis is a single‐center, retrospective, case‐control study. Fifty patients with heart failure (HF) were studied. The etiologies of HF were as follows: ATTRwt, n = 10; previous myocardial infarction (MI), n = 20; and left ventricular hypertrophy (LVH) due to other disease processes (e.g., aortic stenosis), n = 20. We measured the CVR‐R at rest (CVR‐Rrest), CVR‐R with deep breaths (CVR‐Rbreath), and the change rate (CVR‐Rdiff rate). The relative change formula is as follows: CVR‐Rdiff rate = (CVR‐Rbreath − CVR‐Rrest)/CVR‐Rrest 100 (%).ResultsThere was no difference in the CVR‐Rrest levels among the three groups. The CVR‐Rdiff rate levels in the ATTRwt group were significantly lower (ATTRwt: −8.77 [−43.8 to 10.9]; LVH: 67.4 [38.7 to 89.4]; MI: 83.7 [60.4 to 142.9]). Based on the receiver operative characteristic curve analysis to identify ATTRwt in HF, the best cut‐off value for the CVR‐Rdiff rate was 19.7 (area under the curve: 0.848).ConclusionOur data suggested autonomic dysfunction in patients with ATTRwt. Measurement of the CVR‐R in HF patients may be a convenient support tool for the detection of ATTRwt.
Evaluation of the prevalence of illness anxiety disorder following the COVID‐19 pandemic in Iran and its related factors: a cross‐sectional study
Authors: Mahdavifar Neda , Mohammadian Maryam , Kalan Farmanfarma Khadijeh , Khosrorad Razieh , Dizavandi Ahmad R. , Sani Fatemeh V. , Salehiniya Hamid 
Published: November 2022

AbstractBackground and AimsCOVID‐19 pandemic has generated a rise in psychological distress, such as illness anxiety disorder, apart from its negative physical effects. This study intends to the evaluation of illness anxiety disorder rate following the prevalence of COVID‐19 in Iran and its associated factors.MethodsIn this study, 634 people were studied. The data collection method was performed via the virtual networks using a questionnaire, with the sampling method being convenient and nonprobable with the method of snowball. Evans illness anxiety disorder questionnaire was utilized in this investigation. The logistic regression model and the χ2 were used to evaluate the data.ResultsThe prevalence of illness anxiety disorder was 12.1%. The chance to have an illness anxiety disorder in the people whose relatives had a history of COVID‐19 was 5.32 times, and in those who had a relative with a history of COVID‐19 had higher (odds ratio = 1.27). But, this connection in people who worked or studied in nonmedical fields, is several times more than those who are busy in the medical fields. In individuals of 30 years and older, the chance of patients in single people compared to married people was 5.20 times higher, but under the age of 30 years, the chance of illness anxiety disorder in single people was 0.91.ConclusionCOVID‐19 pandemic, also to the physical effects, may have psychological implications for people. Therefore, reducing the individual and social activities in terms of this disease, along with measures related to physical problems, diagnosis, timely treatment and proper psychological consequences, including illness anxiety disorder can be very fruitful.
Real‐world impact of a subsidy decision of sofosbuvir–velpatasvir for treatment of chronic hepatitis C on clinical practice and patient outcomes
Authors: Tan Chee‐Kiat , Luo Xue‐Shi , Ong Benjamin Shao‐Kiat , Lin Liang , Ng Kwong‐Hoe 
Published: November 2022

AbstractBackground and AimSofosbuvir–velpatasvir was recommended for subsidy to treat chronic hepatitis C in Singapore in 2018. We measured the impact of the subsidy decision on clinical practice and patient outcomes. Specifically, we looked at pre‐ and post‐subsidy changes in the utilization and prescribing pattern of chronic hepatitis C treatment and the real‐world clinical effectiveness.MethodUtilization trends and prescribing patterns were assessed using aggregated drug utilization data from public hospitals' dispensing systems and clinical data from the national electronic health record database, respectively. An audit was conducted to evaluate sustained virological response rate 12 weeks post treatment (SVR12).ResultsUse of sofosbuvir–velpatasvir increased sharply since its subsidy listing and dropped subsequently, whereas the utilization of comparator drugs remained low. Prescribing rate of sofosbuvir–velpatasvir increased from 13.7% in the pre‐subsidy period to 90.2% in the post‐subsidy period; 39.1% of patients previously on pegylated interferon and ribavirin switched to sofosbuvir–velpatasvir following its subsidy listing. In the audit, 365 out of 375 patients (97.3% [95% confidence interval: 95.1–98.6%]) achieved SVR12.ConclusionThe subsidy decision led to increased accessibility to patients and intended changes in clinical practice. Sofosbuvir–velpatasvir was also clinically effective in the real world. These findings augur well for the continued eradication of chronic hepatitis C infection in Singapore.
Biomolecule‐releasing bioadhesive for glenoid labrum repair through induced host progenitor cell responses
Authors: Co Cynthia M. , Nguyen Tam , Vaish Bhavya , Izuagbe Samira , Borrelli Joseph , Tang Liping 
Published: November 2022

AbstractGlenoid labral tears occur with repetitive dislocation events and are common injuries observed in shoulder arthroscopic procedures. Although surgery can restore shoulder anatomy, repair is associated with poor clinical outcomes, which may be attributed to the poor regenerative capability of glenoid labral fibrocartilage. Thus, this study was designed to assess whether in situ tissue regeneration via biomolecule‐stimulated recruitment of progenitor cells is a viable approach for the regeneration of labral tears. We developed a click chemistry‐based bioadhesive to improve labral repair and reduce local inflammatory responses due to trauma. Additionally, we previously identified the presence of progenitor cells in the human labrum, which can be recruited by platelet‐derived growth factor (PDGF). Thus, we hypothesized that PDGF‐releasing adhesives could induce the regenerative responses of progenitor cells at the injury site to improve labral healing. In a rat glenoid labral tear model, we evaluated the effect of PDGF‐releasing adhesives on promoting progenitor cells to participate in labral tear healing. After 3 and 6 weeks, the labrum was histologically analyzed for inflammatory responses, progenitor cell recruitment, proliferation, and extracellular matrix (ECM) production (collagen and glycosaminoglycan). Our results showed that adhesives alone considerably reduced local inflammatory responses and labral tissue dissolution. PDGF‐releasing adhesives significantly increased progenitor cell recruitment, proliferation, and ECM production. These results demonstrate that by accelerating autologous progenitor cell responses, PDGF‐releasing adhesives represent a novel clinically relevant strategy to improve the healing of glenoid labral tears.
Erdgas: Mehr als nur Energieträger
Authors: Kuschmitz Paul 
Published: November 2022

AbstractDurch den Angriffskrieg Russlands auf die Ukraine ist Erdgas in Deutschland knapp geworden. Mehr als die Hälfte der Gasimporte kam zuvor aus Russland. Hierzulande wird es nicht nur gebraucht, um Privathaushalte zu heizen, sondern ist auch ein Baustein der chemischen Industrie.
Attitudes and perceptions of healthcare professionals related to family participation in surgical cancer care—A mixed method study
Authors: Trulsson Charlotte , Ahlgren Weimar , Fomichov Victoria , Ågren Susanna , Sandström Per , Björnsson Bergthor , Wennerholm Carina , Drott Jenny 
Published: November 2022

AbstractAimThis study investigated healthcare professionals' attitudes and perceptions towards the family's participation in surgical cancer care.DesignA prospective mixed method study.MethodsThe study was conducted at three hospitals in Sweden with registered nurses, assistant nurses and surgeons. Data included 43 completed Families Importance in Nursing Care (FINC‐NA) questionnaires answered by registered nurses and qualitative data from 14 interviews with surgeons and assistant nurses. Data analysis was performed according to the Creswell convergent parallel mixed method.ResultsBoth quantitative and qualitative data demonstrated that the family was an important resource in nursing care, was highly valued as a conversational partner and had resources that should be considered. Each family should be supported in determining their role and as implements for maintaining a functioning family constellation and increasing their participation.Patient or Public ContributionNo patient or public contribution.
The mediating role of E‐learning motivation on the relationship between technology access and satisfaction with E‐learning
Authors: Innab Adnan , Alqahtani Naji 
Published: November 2022

AbstractAimTo examine the e‐learning motivation mediating role on the relationship between technology access and satisfaction with e‐learning among nursing students during COVID‐19 pandemic.DesignThis is a cross‐sectional, descriptive design.MethodsA convenience sample of students (N = 139) from public and private nursing colleges was recruited in this study. Data were collected using students' satisfaction, motivation and access to technology tools.ResultsNursing students in the study were somewhat satisfied with e‐learning, had access to the required technology for e‐learning and had moderate levels of e‐learning motivation. The multiple regression analysis showed that technology access and e‐learning motivation influenced and explained 30.4% of the variance in satisfaction with e‐learning. Previous experience with e‐learning was associated with satisfaction with e‐learning. A series of regression analyses revealed that e‐learning motivation partially mediated the relationship between technology access and satisfaction with e‐learning.
Factors influencing employment rates and states after liver transplantation in China: A multi‐centre cross‐sectional study
Authors: Zhang Dan , Wang Jing , Tao Zijun , Shi Ying , Wang Huili , Chang Tiantian , Jiang Xiaoyu , Li Xiaofei 
Published: November 2022

AbstractAimThe aim of this study was to assess employment rates and states and the factors influencing liver transplant recipients in China.DesignA cross‐sectional study.MethodsA total of 212 liver transplant recipients were included in this study. Questionnaires for general situation information and the Hospital Anxiety and Depression Scale, Perceived Social Support Scale and Chronic Disease Self‐Efficacy Scale were used.ResultsAmong the liver transplantation, 212 recipients were included in the study, 125 (59%) were employed after liver transplantation compared with 148 (69.8%) who were employed before liver transplantation. Among the 125 recipients that returned to work, only 38.2% thought their employment states were good before liver transplantation, while 81.6% thought that their employment states were good after liver transplantation. Gender, age and employment status before transplantation, aetiology of liver disease, number of physical activities, per capita monthly income, comorbidity and depression were significantly associated with return to work. Self‐efficacy, social support, liver function and nature of work were significantly associated with employment state.
A weak Galerkin finite element method for Allen–Cahn equation with a nonuniform two‐step backward differentiation formula scheme
Authors: Wang Xiuping , Gao Fuzheng , Cui Jintao , Sun Zhengjia 
Published: November 2022

AbstractIn this article, we consider a weak Galerkin finite element method and a nonuniform two‐step backward differentiation formula scheme for solving the Allen–Cahn equation. A discrete weak gradient operator on discontinuous piecewise polynomials is used in the numerical scheme. It is well‐known that the Allen–Cahn equations have a nonlinear stability property, that is, the free‐energy functional decreases with respect to time. A corresponding energy stability analysis of the discretized system is developed. Optimal order of L2‐norm error estimates are derived. Numerical experiments are preformed to support the theoretical results.
The impact of subliminal stimuli on interpersonal trust and team trust
Authors: Cai Jie , Tang Xiangyun , Zhang Jingyu , Sun Xianghong 
Published: November 2022

AbstractAlthough numerous studies related to trust have emerged in recent decades, few studies have explored the impact of subliminal stimuli on trust from an unconscious perspective. This study investigated (a) whether subliminal stimuli could influence interpersonal trust and team trust and (b) whether subjective trust played a mediating role between subliminal stimuli and behavioral trust. It contained two experiments. In Experiment 1, a total of 72 participants took part in a single factor design and completed five tasks. In Experiment 2, a total of 98 participants participated in a single factor design and completed five tasks. Results indicated that subliminal stimuli had a significant impact on interpersonal trust and team trust. Subjective trust played a mediating role between subliminal stimuli and behavioral trust. The results suggest that subliminal priming techniques can influence interpersonal trust and team trust. These techniques first influence subjective trust and then further influence behavioral trust.
Convolutional ProteinUnetLM competitive with long short‐term memory‐based protein secondary structure predictors
Authors: Kotowski Krzysztof , Fabian Piotr , Roterman Irena , Stapor Katarzyna 
Published: November 2022

AbstractThe protein secondary structure (SS) prediction plays an important role in the characterization of general protein structure and function. In recent years, a new generation of algorithms for SS prediction based on embeddings from protein language models (pLMs) is emerging. These algorithms reach state‐of‐the‐art accuracy without the need for time‐consuming multiple sequence alignment (MSA) calculations. Long short‐term memory (LSTM)‐based SPOT‐1D‐LM and NetSurfP‐3.0 are the latest examples of such predictors. We present the ProteinUnetLM model using a convolutional Attention U‐Net architecture that provides prediction quality and inference times at least as good as the best LSTM‐based models for 8‐class SS prediction (SS8). Additionally, we address the issue of the heavily imbalanced nature of the SS8 problem by extending the loss function with the Matthews correlation coefficient, and by proper assessment using previously introduced adjusted geometric mean (AGM) metric. ProteinUnetLM achieved better AGM and sequence overlap score than LSTM‐based predictors, especially for the rare structures 310‐helix (G), beta‐bridge (B), and high curvature loop (S). It is also competitive on challenging datasets without homologs, free‐modeling targets, and chameleon sequences. Moreover, ProteinUnetLM outperformed its previous MSA‐based version ProteinUnet2, and provided better AGM than AlphaFold2 for 1/3 of proteins from the CASP14 dataset, proving its potential for making a significant step forward in the domain. To facilitate the usage of our solution by protein scientists, we provide an easy‐to‐use web interface under https://biolib.com/SUT/ProteinUnetLM/.
Neuroprotective effects of hawthorn leaf flavonoids in Aβ25–35‐induced Alzheimer's disease model
Authors: Xu Ying , Deng Ting , Xie Linjiang , Qin Tao , Sun Tao 
Published: November 2022

AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by β‐amyloid (Aβ) plaques, neurofibrillary tangles, neuronal cell loss, and oxidative stress. Further deposition of Aβ in the brain induces oxidative stress, neuroinflammation, and memory dysfunction. Hawthorn (Crataegus pinnatifida Bge.) leaf, a known traditional Chinese medicine, is commonly used for the treatment of hyperlipidemia, heart palpitations, forgetfulness, and tinnitus, and its main bioactive components are Hawthorn Leaf Flavonoids (HLF). In this study, we investigated the neuroprotective effects of the HLF on the Aβ25–35 (bilateral hippocampus injection) rat model of AD. The results showed that the oral administration of HLF at a dose of 50, 100, and 200 mg/kg for 30 days significantly ameliorated neuronal cell damage and memory deficits, and markedly increased the enzyme activities of superoxide dismutase and catalase, and the content of glutathione whereas it decreased the malondialdehyde content in the Aβ25–35 rat model of AD as well as suppressed the activation of astrocytes. In addition, HLF up‐regulated Nrf‐2, NQO‐1, and HO‐1 protein expressions. Also, it reduced neuroinflammation by inhibiting activation of astrocytes. In summary, these results indicated that HLF decreased the oxidative stress via activating Nrf‐2/antioxidant response element signaling pathways, and may suggest as a potential candidate for AD therapeutic agent.
The blame game of the US baby formula crisis
Authors: Chamlagai Lila K. , Silva Elizabeth , Alikhani Anna 
Published: November 2022

AbstractThe United States cannot meet the demand for infant formula. The nation is currently experiencing a problem due to the industry being controlled by a small number of enterprises, states relying on a single supplier, and a ban on importing infant formula from other nations. The four major corporations’ control 89% of the domestic infant formula market creating an industry monopoly within the United States. Second, the dependence of separate states on a single baby formula provider is the cause of the infant formula shortage. In exchange for granting monopolies to formula producers inside specific areas, the federal government is given price cuts on baby formula goods, enabling it to pay for the acquisition. Finally, the United States's inability to import infant formula has significantly exacerbated the current scarcity. However, in the meanwhile, President Joe Biden's administration has put stopgap measures in place to end this shortage, like loosening limits on imports from abroad, but these measures are unlikely to provide long‐term remedies. A multi‐level strategy with long‐lasting structural adjustments is required to avert future infant formula shortages in the United States, but for the time being, caregivers must find individual‐level solutions to meet their children's nutritional needs.