bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of dapagliflozin on postprandial lipid metabolism in type 2 diabetes mellitus
Authors: Burggraaf Benjamin , Pouw Nadine M C , Fernández Arroyo Salvador , van Vark-van der Zee Leonie C , van de Geijn Gert-Jan M , Birnie Erwin , Huisbrink Jeannine , van der Zwan Ellen M , de Herder Wouter W , Mulder Monique T , Rensen Patrick C N , Castro Cabezas Manuel 
Published: March 2022

Objectives
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) modulate lipid metabolism and improve cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The exact cardioprotective mechanism of SGLT2i is unclear. We evaluated the effects of SGLT2i on postprandial lipids, lipoprotein concentrations, glucose and fatty acids.

Design
A placebo-controlled randomized, proof-of-concept study.

Methods
Fourteen male patients with T2DM on intensive insulin regimen were randomly and double-blind allocated to 12 weeks dapagliflozin (10 mg) or placebo. Postprandial effects were assessed with an 8-h standardized oral fat loading test.

Results
Mean glycated A1c did not change by dapagliflozin, but the mean daily insulin dose was significantly reduced. Although dapagliflozin did not affect fasting or postprandial levels of glucose and insulin, it increased the postprandial levels of glucagon. While fasting levels of free fatty acids and beta-hydroxybutyrate (bHBA) were unchanged, dapagliflozin significantly increased the postprandial bHBA response. This was seen in the context of increased postprandial glucagon levels by dapagliflozin, without influencing postprandial insulin or glucose levels. Dapagliflozin did not affect fasting or postprandial plasma cholesterol and triglycerides nor postprandial inflammatory markers. Fasting apolipoprotein B48 was decreased without affecting the postprandial response. Markers of inflammation and vascular function did not change.

Conclusion
Treatment with dapagliflozin of patients with T2DM led to a reduction of fasting chylomicron remnants and increased postprandial ketone bodies compared to placebo suggesting enhanced hepatic fatty acid oxidation. The latter may have been caused by decreasing the insulin–glucagon ratio. The beneficial clinical effects seen in the trials using dapagliflozin most likely are not due to effects on postprandial inflammation nor postprandial lipemia.
Long-term preservation of germ cells and gonadal tissues at ambient temperatures
Authors: Comizzoli Pierre , He Xiaoming , Lee Pei-Chih 
Published: March 2022

Objective
To present an overview of different approaches and recent advances for long-term preservation of germ cells and gonadal tissues at ambient temperatures.

Methods
Review of the existing literature.

Results
Preserving viable spermatozoa, eggs, embryos, and gonadal tissues for the long term is critical in human fertility treatment and for the management of animal populations (livestock, biomedical models, and wild species). The need and number of banked germplasms are growing very fast in all disciplines, but current storage options at freezing temperatures are often constraining and not always sustainable. Recent research indicates that structures and functions of gametes or gonadal tissues can be preserved for the long term using different strategies based on dehydration and storage at supra-zero temperatures. However, more studies are needed in rehydration and reanimation of germplasms (including proper molecular and cellular evaluations).

Conclusions
While a lot of research is still warranted to optimize drying and rehydration conditions for each sample type and each species, alternative preservation methods will change the paradigm in fertility preservation and biobanking. It will transform the way we maintain and manage precious biomaterials for the long term.

Lay summary
Living sperm cells, eggs, embryos, and reproductive tissues can be preserved at freezing temperatures for human fertility treatments and used to manage breeding in livestock, laboratory animals, and wild species through assisted reproduction. These cells can be stored in cell banks and demand for them is growing fast. However, current long-term storage options at freezing temperatures are expensive. Instead of using low temperatures, recent research indicates that these cells can be dried and stored above freezing temperatures for an extended amount of time. While a lot of research is still needed to optimize how different samples are dried and rehydrated, alternative methods of preserving cells will make fertility preservation and cell banking easier. It will also transform the way we keep and manage samples for the long term.
THE ASSOCIATION BETWEEN GRADE OF PERIODONTITIS AND GCF LEVELS OF TNF-α AND MIP-1α: A PRELIMINARY STUDY
Authors: YİĞİT Umut , KARAASLAN Fatih , DİKİLİTAŞ Ahu , AYDIN Esra Özge 
Published: March 2022

Objective
The role of cytokines and chemokines in the
pathogenesis of periodontitis indicates that tumor
necrosis factor alpha (TNF-α) and macrophage
inflammatory protein 1α (MIP1α) have crucial functions
in the initiation and progression of periodontitis.
However, the cytokine and chemokine profiles of
different grades of periodontitis are still unclear, and
no conclusive information has yet been reported
on biomarkers associated with the progression rate
of periodontitis. Thus, the aim of the present study
was to estimate the gingival crevicular fluid (GCF)
levels of MIP-1α and TNF-α in Grades A, B, and C
and to evaluate their role as reliable biomarkers in
determining the grade of periodontitis.
Materials and Methods
Individuals were divided into three groups according
to their grade of periodontitis: individuals diagnosed as
Stage IV periodontitis with Grade A (Grade A, n = 21),
individuals diagnosed as Stage IV periodontitis with
Grade B (Grade B, n = 21), and individuals diagnosed
as Stage IV periodontitis with Grade C (Grade C,
n = 21).
Results
Although there were no significant differences between
groups in terms of mean TNF-α levels, the mean MIP-
1α level of Grade C was significantly higher than that
of Grade B and Grade A. The mean MIP-1α level of
Grade B was significantly higher than that of Grade A
(p < 0.05, Kruskal–Wallis test).
Conclusion
MIP-1α could have clinical utility as a screening
biomarker for the grade of periodontitis.
Pengaruh Substitusi Tepung Mocaf (Modified Cassava Flour) dan Rumput Laut (Eucheuma cottonii) pada Beras Analog Terhadap Uji Organoleptik dan Kandungan Serat
Authors: Sajidah Viqi , Triwindiyanti Qurrota A'yun Febrina , Afifah Diana Nur , Mahati Endang 
Published: March 2022

Beras analog (BA) merupakan produk dari teknologi pangan berupa beras tiruan yang dapat terbuat dari umbi-umbian, salah satunya adalah mocaf. Beras analog berbahan dasar tepung mocaf ini diperlukan penambahan pangan lain untuk memperkaya nutrisi dan dalam penelitian ini ditambahkan rumput laut Eucheuma cottonii. Pemberian tambahan rumput laut E. cottonii pada beras analog diharapkan dapat meningkatkan kandungan serat beras analog. Penelitian ini bertujuan untuk menganalisis karakteristik organoleptik beras analog serta kandungan seratnya setelah ditambah rumput laut E. cottonii. Penelitian ini menggunakan metode eksperimental dengan rancangan penelitian adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 3 konsentrasi tepung rumput laut E.cottonii yaitu 0, 5, dan 15%. Uji organoleptik dilakukan untuk menentukan kualitas kesukaan. Hasil analisis menunjukkan bahwa rumput laut tidak nyata berpengaruh (p>0,05) terhadap rasa, aroma, dan warna, namun berpengaruh (p<0,05) pada tekstur dan mempunyai daya terima kosumen yang baik. Kandungan serat tertinggi terdapat pada tepung rumput laut, sedangkan kandungan serat tertinggi pada beras analog, terdapat pada konsentrasi 15%. Kesimpulannya, beras analog dengan substitusi tepung mocaf dan tepung rumput laut memiliki daya terima yang baik, tekstur dan kandungan serat yang spesifik.Effect of Substitution of Mocaf (Modified Cassava Flour) Flour and Seaweed (Eucheuma cottonii) on Analogue Rice on Organoleptic Tests and Fiber Content AbstractArtificial rice has been known as the product made of various tubers such as mocaf. This research used Eucheuma cottonii seaweed as additional ingredient to increase the fiber content. The aim of this study was to analyze organoleptic characteristics and fiber content of artificial rice made of mocaf and seaweed. This research used an experimental method with completely randomized design consisting of 3 concentrations of seaweed flours, i.e. 0, 5, and 15%. The results of the organoleptic test analysis showed that taste, aroma, and color were not affected by addtitional seaweed flour (p>0.05), but acceptable for consumer. However, it showed p<0.05 significant effect to fiber content and texture. Fiber content in seaweed flour was found as highest, while in the highest fiber content was found at a concentration of 15% seaweed flour. As conclusion, artificial rice with the substitution of mocaf flour was found as good acceptance for consumer with a spesific value for texture, and fiber content.
Reporting and analysis of Sex and Gender in Transitions of Care for Older Adults: A Methods Study
Authors: Park Hanbyoul , Dewidar Omar , Tanjong-Ghogomu Elizabeth , Welch Vivian 
Published: March 2022

Objectives: Sex and gender based analysis may improve understanding of transitions from long term care to community or health services. Our study aims to assess how sex or gender was reported and analyzed in studies about care transitions for older adults.
Methods: We identified longitudinal studies from a 2017 scoping review on factors affecting care transitions of older adults (participants 60 years and older) and assessed transitions from long-term care to community or health services. We used a pretested coding sheet to assess the reporting of sex or gender in 5 sections of the studies: title and abstract, introduction, methods, results, and discussion.
Results: We included 20 longitudinal studies conducted in 3 countries (United States, Germany, and Finland ) with the study durations ranging from less than 1 year to 10 years. Almost all of the studies reported sex distribution of the sample (18/20; 90%). Sex or gender was discussed in the background and rationale by three out of 20 studies (15%). Twelve studies (60%; 12/20) planned to control for sex or gender in their statistical analysis. Association of sex with outcomes was reported by 45% (9/20) and 3 studies (15%; 3/20) provided disaggregated data on sex or gender.
Conclusion: Almost half of the studies assessing transitions from long-term care to community or health services did not control for sex or gender in their statistical analysis. This may be a missed opportunity for understanding potential sex or gender differences in transitions in care for older adults.
The Stigmatization of Schizophrenia
Authors: Ivanova Maria 
Published: March 2022

The objective of the following systematic literature review was to analyze the current stigma surrounding schizophrenia in North America, its implications, as well as to suggest potential interventions. The current societal climate reveals that many individuals lack an understanding of the etiology and symptoms of schizophrenia, leading to a general negative bias towards individuals with this disease. Additionally, many misperceptions such as enhanced violent tendencies surround patients with schizophrenia, exacerbating negative bias and actions such as avoidance. Suggestions to minimize stigma and its effects were made and include the renaming of schizophrenia, the use of virtual reality programs, the refinement of education programs, and an overall switch in how the media presents schizophrenia.
Integrating Sex Education in Fiqh and Natural Science Subjects at Madrasah Ibtidaiyah
Authors: Muhimmah Tasliyatul , Miftahuddin Miftahuddin 
Published: March 2022

Sex education is not independent as a specific subject in formal education, but its material or content can be found in some subjects, such as Fiqh for the 5th Grade in the chapter of menstruation and khitan, and Natural Science for the 6th Grade in the chapter of human development and growth. This research aimed at knowing the lesson plan, their implementation, and the participation of the school committee in the implementation of sex education. This research used the qualitative method through interviews and documentation in collecting the data. The results showed that most of the teachers of the two subjects have compiled lesson plans but have not implemented them optimally, and there is no participation of the school committee in the implementation of sex education.
RANCIÈRE, CRÍTICO DE MARX: IGUALDADE E POLÍTICA<br/><br/>RANCIÈRE, CRITIC OF MARX: EQUALITY AND POLITICS
Authors: Benzaquen Guilherme Fiqueredo 
Published: March 2022

Jacques Rancière é um intelectual cuja trajetória está marcada por um debate intenso com os escritos de Karl Marx. Propõe-se, neste artigo, analisar as críticas de Rancière a Marx, particularmente as formuladas desde seu rompimento declarado com o marxismo. A análise é feita, em um primeiro momento, a partir de uma crítica imanente das formulações rancièrianas acerca da igualdade e da política. Em um segundo momento, busca-se sistematizar as críticas do filósofo francês a Marx. Por fim, é realizada uma interpelação entre ambos os autores buscando as aproximações e os distanciamentos. O que se verifica é que a comparação entre Rancière e Marx diz respeito principalmente às suas concepções de igualdade e política. Defende-se, assim, que reforçar o já existente diálogo entre eles contribui para os esforços contemporâneos de promoção da igualdade.AbstractJacques Rancière is an intellectual whose trajectory is marked by an intense debate with the writings of Karl Marx. In this article, Rancière’s critiques of Marx are analyzed, particularly those formulated since his declared rupture with Marxism. The analysis is made, at first moment, from an immanent critique of the rancièrian’s arguments about equality and politics. In a second moment, it pursues to systematize the French philosopher’s criticisms of Marx. Finally, an interpellation is made between both authors looking for approximations and distances. What is verified is that the comparison between Rancière and Marx mainly concerns their conceptions of equality and politics. It isargued, therefore, that reinforcing the existing dialogue between them contributes to contemporary efforts to promote equality.
Hydrogels for Water Shut-Off Treatments: Evaluation of a New Polymer Gel System
Authors: Al-Taq Ali , Alhmad Luai , Alrustum Abdullah , Aldarweesh Sajjad 
Published: March 2022

Abstract
Hydrogel polymers have served the oil and gas industry in different applications including water shot-off. Hydrogel polymers can create impermeable gels to optimize water injection profile, improve sweep efficiency, and seal undesirable permeable zones. They have been successfully applied as remediation treatments to control water production from thief zones, natural fractures, and matrix formation.
In this study, a new hydrogel polymer system (HGPS) was examined for water control treatments in sandstone formations. The experimental work included swelling testing, viscosity measurements, and coreflood experiments. The effects of water salinity, HGPS concentrations, pH values and temperature on examined HGPS properties were investigated. The HGPS concentrations examined in this study ranged between 0.3 to 2%, while water salinity ranged from 20,000 to 250,000 mg/L of NaCl. The examined pH values were between 7 and 1 and the temperatures ranged from ambient to 90°C. The coreflood experiments were conducted at 80°C using sandstone core plugs.
The results showed that the viscosity of the HGPS increased with concentration and temperature but decreased with water salinity. The viscosity of the HGPS at 1.5 wt% and at a temperature of 60°C decreased from 575 to 16 cP when the pH value was decreased from 7 to 1. The results also demonstrated that the salinity had a negative impact on swelling properties and, eventually, the HGPS viscosity. Coreflood experiments showed that the HGPS should be squeezed into the core plug at higher injection rates (below frac pressure) in order to achieve high water control. The residual resistant factor to water obtained at an injection rate of 5 cm3/min was 158 while it was found to be &lt; 5 at an injection rate of 1 cm3/min. At lower injecting rate, the HGPS was found to form an external filtercake at the inlet face of the core plug.
The paper presents in detail the major lab findings of the evaluation of a newly developed hydrogel polymer system and recommends the optimum conditions to control water production successfully.
Co2 Foams in Carbonate Reservoirs at High Temperature: Boosting Cationics Formulation Performances By Additives
Authors: Margaux Kerdraon , Eloise Chevallier , Nicolas Gland , Guillaume Batot 
Published: March 2022

Abstract
Injection of foams can be used to optimize different gas injection processes such as CCUS (Carbon Capture Use & Storage) and possibly to boost oil recovery kinetics in heterogenous or naturally fractured reservoirs (Enick R.M. 2012). In this case, foams, which are more viscous and dense than gases, aim at limiting early gas breakthrough during field operation by improving the sweeping efficiency of reservoirs and by blocking the most permeable areas of the latters (A. Al Sumaiti 2017, Chabert M. and D'Souza D. 2016). A large part of the world oil reservoirs that have already been operated by primary and secondary recovery methods are carbonate reservoirs and are mostly located in the Middle East (Talebian S.H. 2014). In these reservoirs, which are often operated by CO2 injection, the adsorption of surfactants on positively charged carbonates may be a major hindrance to foam injection (Pownall 1989, Cui L. and Ma K. 2014). That is why, cationic surfactants have been developed for these CO2 foam applications (Chen Y. 2016). However, these cationics are often hardly soluble at pH&gt;6 (Jian G. 2019) and/or not industrially avalaible (Cui et Dubos 2018).
For this study, we selected three different cationic surfactants. Using automated robotic platforms, we explored a large range of surfactant combination (combining each cationic surfactant with a whole co-surfactant portfolio) at high temperature and in a hard concentrated brine (120g/LTDS, [Ca2+]= 8100ppm). We show that adding co-surfactants to each of these cationics boosts their foaming properties in porous media as well as their solubility at high pH (pH=8) while maintaining low levels of adsorption on carbonates. While a high shear rate is required for cationic surfactants to generate foam in sandpacks, formulations combining cationics and co-surfactants form foams at much lower shear rates. Moreover, the fact that these formulations are soluble at pH=8 means that, on field, the water would no longer need to be acidified at the wellhead to solubilize the surfactant blend. Thus, pipe corrosion induced by the flow of acidified solutions in the surface facilities is prevented. Lastly, all the molecules that are tested in this study are industrially available.
Rocking with Insights of Rock & Fluids and Implementing MICRO Reservoir Management for Enhanced Efficiency & Excellence in Sabiriyah Mauddud, North Kuwait
Authors: Chetri Hom , Al-Shuaib Mariam , Al-Shammari Seham , Jamal Mariam 
Published: March 2022

Abstract
It is a global challenge to comprehensively understand the rock & fluids and the impact of interactions between them to fine tune development plans & strategy. Interpretative & qualitative factors often could lead to sub optimal plans & actions impacting the recovery efficiency. This uncertainty to be minimized, MICRO reservoir management is practiced to reap the benefits in terms of enhanced oil production & water flood efficiency.
Sabiriyah Mauddud is a carbonate reservoir in North Kuwait with a massive development & production enhancement plan with water flood and eventually with EOR. Surprises in terms of rock & fluid (R-F) understanding influenced changes in the development plan in the past, some of such changes triggered major departures from the originally conceived plans. All major turnaround impacted by R-F insights have been reviewed, along with the mitigation plans adopted by the team. MICRO (Monitoring Integrating Communicating Re-vitalizing Orchestrating) is a new buzz concept, initiated by authors in the industry, to improve the overall excellence & efficiency. The concept has been implemented with associated workflow processes to optimize the water flood development. A typical diagnostics of the segment under water flood is done to illustrate the value of R-F understanding & reservoir management of the giant carbonate reservoir in North Kuwait.
A comprehensive data acquisition, integration & interpretation plan helps in reducing the uncertainties while the reservoir is under active production & injection. Carefully planned appraisal programs have added insights to understand the relatively less-understood flanks. R-F and interactions understanding is augmented by laboratory studies & focused surveillance data. Additionally, MICRO proved to be the backbone for complete gamut of activities so as to reduce the uncertainties & gaps. The segment reviews led to many vital decisions on thief zones, fractures, re-circulation on injected water, connectivity between producers & injectors, actions on producers / injectors for conformance improvement and opportunities for oil gain with reduced water cut. Work flow processes have been standardized and validated with successful trials.
R-F - Interaction linkage to water flood & production efficiency using MICRO approach is a proven way to manage a giant & complex carbonate reservoir in North Kuwait, the results of which are interesting & worth sharing with the global professionals.