bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling
Authors: Lex Rachel K. , Vokes Steven A. 
Published: October 2022

AbstractHedgehog (HH) signaling is a conserved pathway that drives developmental growth and is essential for the formation of most organs. The expression of HH target genes is regulated by a dual switch mechanism where GLI proteins function as bifunctional transcriptional activators (in the presence of HH signaling) and transcriptional repressors (in the absence of HH signaling). This results in a tight control of GLI target gene expression during rapidly changing levels of pathway activity. It has long been presumed that GLI proteins also repress target genes prior to the initial expression of HH in a given tissue. This idea forms the basis for the limb bud pre‐patterning model for regulating digit number. Recent findings indicate that GLI repressor proteins are indeed present prior to HH signaling but contrary to this model, GLI proteins are inert as they do not regulate transcriptional responses or enhancer chromatin modifications at this time. These findings suggest that GLI transcriptional repressor activity is not a default state as assumed, but is itself regulated in an unknown fashion. We discuss these findings and their implications for understanding pre‐patterning, digit regulation, and HH‐driven disease.
Greeting skills: A systematic review of the literature
Authors: Hickey Carleana R. , Reeve Sharon A. , Reeve Kenneth F. , Deshais Meghan A. 
Published: October 2022

AbstractIndividuals with disabilities often demonstrate difficulty in social communication skills such as greetings. Studies have shown that deficits in greetings may negatively affect social interactions and vocational opportunities. Therefore, previous research has evaluated a variety of teaching procedures to increase greetings for individuals with disabilities with varying efficacy. This review of the literature provides an overview of studies to date in which greetings were taught to individuals with intellectual disabilities. A variety of teaching procedures were identified, and implications of those procedures are discussed. Results suggest that multiple teaching procedures may be effective; however, component analyses, further replication, and modified generalization procedures are necessary. Implications for future researchers include identifying a technological definition of greetings and evaluating effective teaching procedures and generalization strategies. Implications for practitioners include teaching one greeting type at a time, limiting the number of social skills taught simultaneously, identification of effective teaching procedures and generalization considerations.
Authentication of Cyathulae Radix and Cyathulae Capitatae Radix based on the strength of the characteristic component achybidensaponin I
Authors: Ma Yanhong , Gao Bixing , Qi Jingliang , Gou Yan , Li Zhi , Chen Yingxin , Li Min , Zhou Juan , Zhong Lian , Cai Xiaoyang 
Published: October 2022

AbstractBecause of the immense difficulty in identifying Cyathulae Capitatae Radix adulteration in Cyathulae Radix, this research aims at fortifying the quality control of Cyathulae Radix and its decoction pieces to guarantee the effectiveness and safety of its clinical use in terms of source material. A method was devised to identify Cyathulae Capitatae Radix adulteration in Cyathulae Radix and its decoction pieces. This research takes achybidensaponin I, that is, the characteristic component of Cyathulae Capitatae Radix, as reference substance and adopts HPLC for detection. The results revealed that, among all samples collected, no trace of achybidensaponin I was found in the 21 batches of Cyathulae Radix, whereas achybidensaponin I was found in all the 14 batches of Cyathulae Capitatae Radix. The research sets 5% as the adulteration limit, that is, 1.45 mg/g Cyathulae Capitatae Radix was detected in 57.14% of the 49 batches of market samples collected and the ratio was 51.02% in the case of 5% adulteration limit. The method is not only precise and reliable but can also be used as a supplement for provisions regarding quality control of Cyathulae Radix and its decoction pieces in Pharmacopoeia of the People's Republic of China, to effectively crack down on Cyathulae Capitatae Radix adulteration in the market.
A high‐dimensional inverse norm sign test for two‐sample location problems
Authors: Huang Xifen , Liu Binghui , Zhou Qin , Feng Long 
Published: October 2022

AbstractIn this article, we focus on the two‐sample location testing problem for high‐dimensional data, where the data dimension is potentially much larger than the sample sizes. First, we construct a general class of weighted spatial sign tests for the two‐sample location problem, which can include some existing high‐dimensional nonparametric tests. Then, in this article, we find a locally most powerful test by choosing the inverse norm weight function, named the two‐sample inverse norm sign test (tINST). The proposed test can be viewed as an extension of the inverse norm sign test devised for the one‐sample problem. We establish the asymptotic properties of the proposed test, which indicate that it is consistent and has greater power than competing tests that belong to the proposed class of weighted spatial sign tests for two‐sample location problems. Finally, a large number of numerical investigations and a practical biomedical example demonstrate the power and robustness advantages of the proposed test.
Effect of a High‐Fat Meal on Single‐Dose Rencofilstat (CRV431) Oral Bioavailability in Healthy Human Subjects
Authors: Remenchik Ellen , Mayo Patrick R. , Hobbs Todd M. , Greytok Jill A. , Foster Erin P. , Zhao Caroline , Ure Daren , Trepanier Daniel J. , Foster Robert T. 
Published: October 2022

AbstractRencofilstat (RCF) is a novel cyclophilin inhibitor under development for the treatment of nonalcoholic steatohepatitis and hepatocellular carcinoma. This phase 1, randomized, open‐label study in healthy participants assessed the relative bioavailability of a single dose of RCF 225‐mg soft gelatin capsules in both fasted and high‐fat conditions. Forty‐four participants were enrolled to either the fasted (n = 24) or the high‐fat fed (n = 20) arm. Noncompartmental pharmacokinetics were evaluated following a single 225‐mg oral dose. Administration of RCF with a high‐fat meal led to increases in maximum concentration, area under the concentration–time curve (AUC) from time 0 to 24 hours, and AUC from time 0 to infinity fed‐to‐fasted geometric mean ratios of 102.2%, 114.5%, and 132.9%, respectively. All AUC geometric mean ratios were outside of the 80% to 125% range, suggesting that a high‐fat meal can increase the extent of RCF exposure. Time to maximum concentration increased from 1.5 to 1.8 hours in the fasted and high‐fat groups, respectively, suggesting slightly delayed absorption. High fat intake may delay gastric emptying while increasing the absorption and bioavailability of RCF. No treatment‐emergent adverse events were observed in the fasted group, and 1 treatment‐emergent adverse event occurred in the high‐fat meal group. The differences in observed whole‐blood concentrations are unlikely to have clinically relevant effects given the wide therapeutic index of RCF demonstrated in previous phase 1 studies.
SIMCard: Toward better connected electronic health record visualization
Authors: Sassi Salma , Chbeir Richard 
Published: October 2022

SummaryRecently, several healthcare organizations use decision‐making systems based on electronic health record (EHR) data in order to guarantee patient's safety and improve the quality of healthcare. In essence, the evolutions of Internet of Things (IoT) technologies have been of great help for implementing an integrated and interoperable decision‐making system based on EHR and medical devices (MDs). Those IoT‐based systems allow Clinicians collecting real‐time health data and provide accurate patient's monitoring. Nevertheless, several studies have shown that it is hard to improve the quality of healthcare using the current EHR IoT‐based systems since they do not allow to easily express clinician needs. Interactive visualization tools have been proposed to improve the efficacy and utility of these EHR based systems. However, there is no framework that provides a visual summary of patient data to clinician for planning specific clinical tasks, subsequently evaluating clinician responses, visually exploring EHR data and MDs data, gaining insights, supporting dynamic coordination processes care, and forming and validating hypotheses and risks. This article addresses this problem and introduces SIMCard, an aggregation‐based connected EHR visualization framework for patient monitoring, interpreting and predicting with MDs. The proposed framework aims to synthesize patient's clinical data into a single aggregating model for both EHR and MD conforming to health standard and terminologies. It also allows to link the aggregating model to the relevant medical knowledge in order to provide a connected and dynamic care and preventive plan. Last but not least, it provides an aggregated visualization model capable of displaying graphically a patient's personal data from databases, healthcare devices and sensors to reduce cognitive barriers related to the complexity of medical information and interpretation of health data. To demonstrate the refinement and design of our system and to observe user's actual practice of visualizing and analyzing real‐world dataset, we evaluated our system and compare to existing ones.
Optimal transmit antenna selection for non‐orthogonal multiple access with improved lion algorithm
Authors: Jadhav Kishor , Vidyarthi Abhay 
Published: October 2022

SummaryIn the realm of 5G mobile wireless communication, cognitive radio (CR) plays an important role in improving radio spectrum efficiency by overcoming challenges such as spectrum shortage versus under‐utilization associated with the traditional fixed frequency assignment. “Interweave CR, underlay CR, and overlay CR” are the three primary paradigmatics in general. The present study focuses on the overlay CR paradigm, wherein secondary users (SUs) have all been expected to be provided with superior “encoding and signal processing techniques” to improve primary users' (PUs') communication. Furthermore, to address concerns associated with inefficient spectrum usage, multiplexing methods like “non‐orthogonal multiple access (NOMA) and spatial modulation (SM)” have been implemented. NOMA makes use of the power domain to maximize spectrum usage, whereas SM makes use of the spatial domain. Multiple antennas, on the other hand, are expensive in terms of energy, magnitude, and equipment. Antenna selection is a low‐cost, low‐complexity method of capturing many of the NOMA system's advantages. As a consequence, this study offers the fitness familiarized lion algorithm (FFLA), a novel methodology for selecting the best antennas. Furthermore, the selection procedure involves identifying the stated objectives, which include energy usage and error minimization. Indeed, the suggested technique is an enhanced version of the lion algorithm (LA). Ultimately, the suggested work's performance is compared to and proven against other traditional models.
Human dense avoidance based on a coverage control through robots
Authors: Morita Shu , Okura Yuki , Kojima Chiaki 
Published: October 2022

AbstractIn this paper, we propose an efficient method for human dense avoidance based on a coverage control. Our motivation is to avoid crowding in public facilities such as stations and government offices, and human dense in the current situation of COVID‐19 from system and control theory. In this paper, humans and robots are modeled as heterogeneous and homogeneous agents, respectively, which make decisions based on their local information. We suppose a dense situation caused by the rendezvous among humans due to their own inherent dynamics. As a main result, we propose a coverage control for a distributed movement of multiple humans. We also characterize the stationary point analytically in terms of the gains that describe a strength of the interconnection of the agents, and the centers of the Voronoi regions related to the agents. Moreover, we verify the meaning of the characterization from an engineering viewpoint of the dense avoidance. Finally, we show the efficiency of the method based on a numerical simulation.
Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum
Authors: Butler Javed , Usman Muhammad Shariq , Anstrom Kevin J. , Blaustein Robert O. , Bonaca Marc P. , Ezekowitz Justin A. , Freitas Cecilia , Lam Carolyn S.P. , Lewis Eldrin F. , Lindenfeld JoAnn , McMullan Ciaran J. , Mentz Robert J. , O'Connor Christopher , Rosano Giuseppe M.C. , Saldarriaga Clara Inés , Senni Michele , Udelson James , Voors Adriaan A. , Zannad Faiez 
Published: October 2022

AbstractPatients with heart failure with reduced ejection fraction (HFrEF) have a high residual risk of adverse outcomes, even when treated with optimal guideline‐directed medical therapy and in a clinically stable state. Soluble guanylate cyclase (sGC) stimulators have the potential to lower this risk by modifying the nitric oxide–sGC–cyclic guanosine monophosphate cascade – a pathophysiological pathway that has been targeted with limited success in HFrEF previously. Vericiguat, an sGC stimulator, was shown to improve outcomes in patients with HFrEF in the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial. However, this trial included patients with recently worsening disease. In this brief review, we discuss the rationale of evaluating sGC stimulators in lower‐risk HFrEF patients. First, all key HFrEF medications have been evaluated in both higher‐ and lower‐risk populations, and the treatment effect is not always consistent across the risk spectrum. Second, pre‐clinical studies and post‐hoc studies of the VICTORIA trial have suggested that sGC stimulators may have cardioprotective effects – these effects may be more apparent when the medication is initiated earlier in the disease process. Third, the effect of vericiguat on cardiovascular mortality remains uncertain and a trial with a longer follow‐up in a lower‐risk population may allow better assessment of its effect on cardiovascular mortality. Therefore, there is a pertinent need to investigate the effects of vericiguat in optimally treated, low‐risk HFrEF patients (i.e. those without recently worsening heart failure).
Change in Oil Composition and the Major Fatty Acids and Triacylglycerol Biosynthesis Genes in Drupe of Selected Olive Cultivars during Growing Season; A Two Years Study
Authors: Razeghi‐Jahromi Fateme , Zarei Abdolkarim , Parvini Farshid , Hosseini‐Mazinani Mehdi 
Published: October 2022

AbstractUncovering the relationships between the content and compositions of olive oil, environmental factor, and developmental stages can lead to the effective cultivation choices and maximizing productivity. Fatty acid contents of 4 olive cultivars are screened at 5 developmental stages during 2 cropping seasons. Moreover, the transcript abundance of 4 fatty acids and triacylglycerol biosynthesis genes are evaluated in 2 cultivars displaying distinct oil content and composition. Thought, all studied cultivars display a rise in oil content and a decline in oleic/linoleic acid as maturity advances, the fatty acid content, however changes in a cultivar‐dependent manner. In contrast to other cultivars, “Mari” shows an increasing trend for oleic acid and fruit RH, and steady state pattern for linoleic acid during fruit development. All these characteristics result in a unique oil quality in “Mari”. Accordingly, there are slight differences in the oil related‐attributes in 2 cropping years at different sampling dates which are also cultivar dependent. The expression patterns of oil biosynthesis genes are well‐paralleled with oil accumulation and compositions in the studied olive cultivars; as OeSAD2 and OeDGAT2 experience a significant higher expression in “Mari”, while “Shengeh” has higher levels for OeFAD2‐2 and OeDGAT1 during most sampling times.Practical Applications: According to these data, the lower expression of OeFAD2‐2, as well as, substantially higher expression of OeSAD2 and OeDGAT2 are suggested as the major players for higher oil and oleic acid production in “Mari”. Results obtained from this study improve knowledge about oil biosynthesis in olive drupe in relation to fruit ripening and environmental factors. These data are useful for both growers and experts enabling them to make more appropriate planting and harvest decisions, as well as, to design suitable breeding programs to achieve olive improvement objectives.
Forecasting and trading Bitcoin with machine learning techniques and a hybrid volatility/sentiment leverage
Authors: Wei Mingzhe , Sermpinis Georgios , Stasinakis Charalampos 
Published: October 2022

AbstractThis paper explores the use of machine learning algorithms and narrative sentiments when applied to the task of forecasting and trading Bitcoin. The forecasting framework starts from the selection among 295 individual prediction models. Three machine learning approaches, namely, neural networks, support vector machines, and gradient boosting approach, are used to further improve the forecasting performance of individual models. By taking data‐snooping bias into account, three different metrics are applied to examine the forecasting ability of each model. Our results suggest that the machine learning techniques always outperform the best individual model whereas the gradient boosting framework has the best performance among all the models. Finally, a time‐varying leverage trading strategy combined with narrative sentiments and volatility is proposed to enhance trading performance. This suggests that the hybrid leverage strategy provides the highest Bitcoin profits consistently among all trading exercises.
Prevention of quality characteristic decline in freeze‐thawed cultured large yellow croaker (Larimichthys crocea) using flammulina velutipes polysaccharide
Authors: Shi Yuzhuo , Zheng Yao , Li Baoguo , Yang Xu , Guo Quanyou , Liu Anqi 
Published: October 2022

AbstractTo investigate the cryoprotective effect of flammulina velutipes polysaccharide (FVP) on the quality characteristics in freeze‐thawed cultured large yellow croaker, 0.050%, 0.075%, and 0.100% FVP was used before freezing and the quality after thawing was compared with water soaking (WS) and commercial cryoprotectant (CC) treatment. Quality attributes were comprehensively determined instrumentally and organoleptically after thawing at 4°C. Results showed that FVP effectively reduces the quality deterioration of body color and water‐holding capacity, while no obvious effects were observed in texture and flavor. As for body color, both FVP and CC treatment could maintain the b* value to a large extent. Among them, 0.075% FVP shows the highest value in two sample points, with 55.2% and 21.0% increases seen in the values in WS. FVP‐dose‐dependent trends were found in water‐holding capacity, where a reduction of 28.26% and 14.38% in thawing loss and cooking loss was observed in the 0.100% FVP group. Low‐field nuclear magnetic resonance (LF‐NMR) also revealed that immobilized water and free water were more tightly retained in the muscle tissue with FVP addition. The results of the sensory evaluation are essentially in line with the above observations. These findings indicate that FVP has the potential to partially replace commercial cryoprotectants in aquatic products during frozen storage.
Unsteady MHD natural convection flow past an infinite vertical porous plate with radiation absorption effects
Authors: Hamad Najiba Hasan 
Published: October 2022

AbstractIn this paper, we have explored the unsteady hydromagnetic free convective flow over an infinite perpendicular porous plate with temperature resource and/or radiation absorption. The prevailing equations are subsequently resolved systematically by utilizing perturbation methodology. The velocity, temperatures as well as concentrations sketches are shown in graphics. The impacts in the flow area for dissimilar leading parameters have been explored. Also, the skin friction, Nusselt quantity along with Sherwood quantity are computed with different parameters and mentioned in the tables. The velocity diminishes with escalating in the chemically reacting parameter as well as improves with an increment in temperature resource parameters. The temperature field reduces with an augment in the Prandtl number, whereas it enlarges with an augment in temperature absorption parameters. The concentrations field is enhanced by an amplifying in chemically reacting variable, whereas it lessens with an amplifying Schmidt number.
Discharge and floods projected to increase more than precipitation extremes
Authors: Quintero Felipe , Villarini Gabriele , Prein Andreas F. , Zhang Wei , Krajewski Witold F. 
Published: October 2022

AbstractFloods claim a high toll in fatalities and economic impacts. Despite their societal relevance, there is much more to learn about the projected changes in discharge and flooding. Here we force an operational hydrologic model over the state of Iowa with high‐resolution convection‐permitting climate‐model precipitation to evaluate the response of 140 watersheds to climate change. At the end of the century, under the most aggressive scenario in terms of fossil fuel use, we show that the transition from snow to rainfall and approximately 30% increase in extreme precipitation rates lead to a doubling of maximum discharge during the spring and extending the flood season into the fall. Total discharge volumes are also expected to increase. Our results suggest that flood projections based on extreme precipitation increases alone substantially underestimate future risk due to the non‐linearity of the hydrologic response explained by long‐term soil moisture memory and its feedbacks with precipitation. This study is one of the first to show floods are increasing due to the prevalence of rain‐on‐snow events, and indeed that discharge might increase more than precipitation.