bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local and global energy barriers for chiral domain walls in synthetic antiferromagnet–ferromagnet lateral junctions
Authors: Yoon Jiho , Yang See-Hun , Jeon Jae-Chun , Migliorini Andrea , Kostanovskiy Ilya , Ma Tianping , Parkin Stuart. S. P. 
Published: October 2022

AbstractOf great promise are synthetic antiferromagnet-based racetrack devices in which chiral composite domain walls can be efficiently moved by current. However, overcoming the trade-off between energy efficiency and thermal stability remains a major challenge. Here we show that chiral domain walls in a synthetic antiferromagnet–ferromagnet lateral junction are highly stable against large magnetic fields, while the domain walls can be efficiently moved across the junction by current. Our approach takes advantage of field-induced global energy barriers in the unique energy landscape of the junction that are added to the local energy barrier. We demonstrate that thermal fluctuations are equivalent to the magnetic field effect, thereby, surprisingly, increasing the energy barrier and further stabilizing the domain wall in the junction at higher temperatures, which is in sharp contrast to ferromagnets or synthetic antiferromagnets. We find that the threshold current density can be further decreased by tilting the junction without affecting the high domain wall stability. Furthermore, we demonstrate that chiral domain walls can be robustly confined within a ferromagnet region sandwiched on both sides by synthetic antiferromagnets and yet can be readily injected into the synthetic antiferromagnet regions by current. Our findings break the aforementioned trade-off, thereby allowing for versatile domain-wall-based memory, and logic, and beyond.
Intra-beat biomarker for accurate continuous non-invasive blood pressure monitoring
Authors: Abiri Arash , Chou En-Fan , Qian Chengyang , Rinehart Joseph , Khine Michelle 
Published: October 2022

AbstractAccurate continuous non-invasive blood pressure (CNIBP) monitoring is the holy grail of digital medicine but remains elusive largely due to significant drifts in signal and motion artifacts that necessitate frequent device recalibration. To address these challenges, we developed a unique approach by creating a novel intra-beat biomarker (Diastolic Transit Time, DTT) to achieve highly accurate blood pressure (BP) estimations. We demonstrated our approach’s superior performance, compared to other common signal processing techniques, in eliminating stochastic baseline wander, while maintaining signal integrity and measurement accuracy, even during significant hemodynamic changes. We applied this new algorithm to BP data collected using non-invasive sensors from a diverse cohort of high acuity patients and demonstrated that we could achieve close agreement with the gold standard invasive arterial line BP measurements, for up to 20 min without recalibration. We established our approach's generalizability by successfully applying it to pulse waveforms obtained from various sensors, including photoplethysmography and capacitive-based pressure sensors. Our algorithm also maintained signal integrity, enabling reliable assessments of BP variability. Moreover, our algorithm demonstrated tolerance to both low- and high-frequency motion artifacts during abrupt hand movements and prolonged periods of walking. Thus, our approach shows promise in constituting a necessary advance and can be applied to a wide range of wearable sensors for CNIBP monitoring in the ambulatory and inpatient settings.
Chronic liver disease and hepatic calcium-oxalate deposition in patients with primary hyperoxaluria type I
Authors: Recker Pia , Beck Bodo Bernhard , Sikora Przemyslaw , Göbel Heike , Kemper Markus Josef , Nazco Angel , Martin-Higueras Cristina , Hoppe Bernd 
Published: October 2022

AbstractPatients with primary hyperoxaluria type I (PH I) are prone to develop early kidney failure. Systemic deposition of calcium-oxalate (CaOx) crystals starts, when renal function declines and plasma oxalate increases. All tissue, but especially bone, heart and eyes are affected. However, liver involvement, as CaOx deposition or chronic hepatitis/fibrosis has never been reported. We examined liver specimen from 19 PH I patients (aged 1.5 to 52 years at sample collection), obtained by diagnostic biopsy (1), at autopsy (1), or transplantation (17). With polarization microscopy, birefringent CaOx crystals located in small arteries, but not within hepatocytes were found in 3/19 patients. Cirrhosis was seen in one, fibrosis in 10/19 patients, with porto-portal and nodular fibrosis (n = 1), with limitation to the portal field in 8 and/or to central areas in 5 patients. Unspecific hepatitis features were observed in 7 patients. Fiber proliferations were detectable in 10 cases and in one sample transformed Ito-cells (myofibroblasts) were found. Iron deposition, but also megakaryocytes as sign of extramedullary erythropoiesis were found in 9, or 3 patients, respectively. Overall, liver involvement in patients with PH I was more pronounced, as previously described. However, CaOx deposition was negligible in liver, although the oxalate concentration there must be highest.
Regulation of serine palmitoyl-transferase and Rac1–Nox2 signaling in diabetic retinopathy
Authors: Alka Kumari , Mohammad Ghulam , Kowluru Renu A. 
Published: October 2022

AbstractHyperlipidemia is considered as one of the major systemic factors associated with the development of diabetic retinopathy, and animal models have documented that its presence in a hyperglycemic environment exacerbates cytosolic ROS production (via activation of the Rac1–Nox2 axis) and mitochondrial damage. Hyperglycemia also accelerates Rac1 transcription via dynamic DNA methylation–hydroxymethylation of its promoter. In diabetes, ceramide metabolism in the retina is impaired and its accumulation is increased. Our aim was to investigate the effect of inhibition of the rate limiting enzyme of the de novo ceramide biosynthesis, serine palmitoyl-transferase (SPT), on Rac1 activation in diabetic retinopathy. Using human retinal endothelial cells, transfected with SPT-siRNA, and incubated in 20 mM d-glucose in the presence or absence of 50 µM palmitate (glucolipotoxic and glucotoxic, respectively), activities of Rac1 and Nox2, and ROS levels were quantified. For Rac1 transcriptional activation, 5 hydroxymethyl cytosine (5hmC) levels at its promoter were quantified. Key parameters were confirmed in retinal microvessels from streptozotocin-induced diabetic mice on a normal diet (type 1 diabetic model) or on a high-fat diet (45% kcal, type 2 diabetic model), injected intravitreally with SPT-siRNA. Compared to normal glucose, cells in high glucose, with or without palmitic acid, had increased Rac1–Nox2–ROS signaling, Rac1 transcripts and 5hmC levels at its promoter. Inhibition of SPT by SPT-siRNA or myriocin prevented glucotoxic- and glucolipotoxic-induced increase in Rac1–Nox2–ROS signaling and 5hmC at the Rac1 promoter. Similarly, in both type 1 and type 2 diabetic mouse models, SPT-siRNA attenuated the increase in the Rac1–Nox2–ROS axis and 5hmC at the Rac1 promoter. Thus, inhibition of the rate limiting enzyme of ceramide de novo biosynthesis, SPT, regulates activation of DNA methylation–hydroxymethylation machinery and prevents increased Rac1 transcription. This ameliorates the activation of Rac1–Nox2 signaling and protects the mitochondria from damaging cytosolic ROS, which prevents accelerated capillary cell loss. These results further raise the importance of regulating lipid levels in diabetic patients with dyslipidemia.
Retinal vascular assessment in psoriatic patients with and without metabolic syndrome using optical coherence tomography angiography
Authors: Tolba Doaa Ahmed , Amin Rana Hussein , Alorbani Aya Magdi , Mamdouh Esmat Sara 
Published: October 2022

AbstractTo evaluate the retinal vasculature in psoriasis patients and detect if metabolic syndrome is an additional risk factor. This cross-sectional analytic study was carried out on 80 eyes of 80 subjects; 28 eyes with psoriasis only (PS group), 12 eyes with additional metabolic syndrome to psoriasis (PMS group) and 40 eyes healthy controls (HS). The retinal capillary plexuses were evaluated by OCTA. The disease activity was evaluated by the Psoriasis Area and Severity Index (PASI) score and extent. The superficial capillary plexus (SCP) vascular density was significantly lower in PS group than HS while in PMS it was significantly lower only in whole image and superior and temporal perifoveal areas (p-value = 0.020, 0.030, 0.001 respectively). The changes correlated with the disease duration. The vascular density of the deep capillary plexus (DCP) was significantly lower in both PS and PMS groups (p-value < 0.001). Psoriatic patients are at a higher risk of developing retinal vascular complications even without evident clinical ocular disease. It was noted that the presence of metabolic syndrome contributes as an additional risk factor in possible visual loss secondary to ischemic changes that are likely to start in the DCP and progress to involve all levels.
Gut microbiota shift in layer pullets fed on black soldier fly larvae-based feeds towards enhancing healthy gut microbial community
Authors: Ndotono Evalyne W. , Khamis Fathiya M. , Bargul Joel L. , Tanga Chrysantus M. 
Published: October 2022

AbstractGlobally, most gut microbiota-related studies have focused on broilers due to their diverse microbial communities compared to that of layer chicken. However, in Africa few studies have been undertaken despite the increasing benefits to the poultry industry. The utilization of Insect-Based diets to improve the gastrointestinal function and gut health in poultry is increasingly gaining global attention. Here, we evaluated the potential roles of commercial black soldier fly larvae-based feeds (BSFLF) in reshaping the abundance, composition and diversity of the gut microbiota of layer chickens using high throughput Oxford nanopore Minion sequencing of the full length bacterial 16S rRNA gene. Two hundred and fifty ISA Brown layer chicks were reared in pens for a period of 20 weeks. The layer pullets were allotted 5 dietary treatments that were formulated as follows: control diet (T1): 100% FM + 0% BSFL, T2: 25% BSFL + 75% FM; T3: 50% BSFL + 50% FM; T4: 75% BSFL + 25% FM, and T5: 100% BSFL + 0% FM. Sampling was done from the eight major regions including oesophagus, crop, proventriculus, gizzard, duodenum, ileum, large intestines and ceca. Out of the 400,064 classified reads analyzed, the most dominant phyla identified across the feed treatments were Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria. The diet treatment with 100% inclusion levels of BSFL showed the highest intra-species alpha diversity and richness according to Chao1 and Shannon index. Intra-species beta diversity assessment revealed that the diet types significantly influenced the abundance of the microbiota, but differences between most abundant taxa were similar. There was increase in abundance of potentially beneficial bacteria (Lactobacillus, Bacteroides and Enterococcus) with increased inclusion levels of BSFLF in layer pullets diets. Across the different gut segments, Lactobacillus dominated all the eight regions and the ceca was the most diverse segment. Our findings unravel complex gut microbial shift in laying hen fed BSFLF and therefore underpins the potential roles of beneficial bacteria as promising prebiotics and probiotics in reshaping of the gut microbiota to maintain good gut health.
Quantifying the relationship between specialisation and reputation in an online platform
Authors: Livan Giacomo , Pappalardo Giuseppe , Mantegna Rosario N. 
Published: October 2022

AbstractOnline platforms implement digital reputation systems in order to steer individual user behaviour towards outcomes that are deemed desirable on a collective level. At the same time, most online platforms are highly decentralised environments, leaving their users plenty of room to pursue different strategies and diversify behaviour. We provide a statistical characterisation of the user behaviour emerging from the interplay of such competing forces in Stack Overflow, a long-standing knowledge sharing platform. Over the 11 years covered by our analysis, we represent the interactions between users and topics as bipartite networks. We find such networks to display nested structures akin to those observed in ecological systems, demonstrating that the platform’s user base consistently self-organises into specialists and generalists, i.e., users who focus on narrow and broad sets of topics, respectively. We relate the emergence of these behaviours to the platform’s reputation system with a series of data-driven models, and find specialisation to be statistically associated with a higher ability to post the best answers to a question. We contrast our findings with observations made in top-down environments—such as firms and corporations—where generalist skills are consistently found to be more successful.
Field evolved insecticide resistance in the cotton mealybug Phenacoccus solenopsis and its direct and indirect impacts on the endoparasitoid Aenasius arizonensis
Authors: Shankarganesh Karuppan , Ricupero Michele , Sabtharishi Subramanian 
Published: October 2022

AbstractPhenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae) an invasive mealybug on cotton is primarily controlled by conventional insecticides. An endoparasitoid Aenasius arizonenesis (Girault) (Hymenoptera: Encyrtidae) is a potential biocontrol agent of this pest. We assessed the susceptibility in field populations of P. solenopsis and A. arizonensis to commonly used insecticides: profenofos, imidacloprid and thiodicarb. Reproductive traits of the parasitoid and Environmental Risk Assessment (ERA) parameters viz., Reduction coefficient, Descriptive analysis, Risk Index (RI), Selectivity ratio and Hazard quotient were measured to assess the direct and indirect effects of these insecticides on the parasitoid. Probit analysis revealed heterogeneity in the insecticide resistance development for both the cotton mealybug and its parasitoid. The field populations of P. solenopsis exhibited resistance to profenofos (18.87–59.86 folds) and thiodicarb (20.07 folds) and susceptibility to imidacloprid. Development of resistance to profenofos was observed in field populations of A. arizonensis. Exposure to lethal doses of imidacloprid and profenofos caused a reduction in parasitization (19–23%) and adult emergence (62–69%) of the parasitoid. Profenofos, thiodicarb and imidacloprid were found to be hazardous, non-selective and harmful to the endoparasitoid, A. arizonensis. There is an urgent need for optimizing insecticide applications for sustainable management of this invasive mealybug in cotton.
The ratio of 12α to non-12-hydroxylated bile acids reflects hepatic triacylglycerol accumulation in high-fat diet-fed C57BL/6J mice
Authors: Iwasaki Wakana , Yoshida Ryo , Liu Hongxia , Hori Shota , Otsubo Yuki , Tanaka Yasutake , Sato Masao , Ishizuka Satoshi 
Published: October 2022

AbstractIn our previous study, enterohepatic 12α-hydroxylated (12α) bile acid (BA) levels were found to be correlated with hepatic triacylglycerol concentration in rats fed high-fat (HF) diet. Since BA composition is diverse depending on animal species, we evaluated whether such a relationship is applicable in mice in response to an HF diet. C57BL/6JJmsSLC (B6) male mice were fed HF diet for 13 weeks and analyzed for triacylglycerol, cholesterol, oxysterols, and other metabolites in the liver. The BA composition was determined in the liver, small intestinal contents, portal plasma, aortic plasma, and feces. Neutral sterols were also measured in the feces. The ratio of 12α BA/non-12 BA increased in the liver, portal plasma, small intestinal contents, and feces of HF-fed B6 mice. Moreover, a positive correlation was observed between the ratio of fecal 12α BAs/non-12 BAs and hepatic triacylglycerol concentration. The concentration of 7α-hydroxycholesterol was increased in the liver of HF-fed B6 mice, whereas no increase was observed in the hepatic expression of cytochrome P450 family 7 subfamily A member 1. The present study showed that the ratio of 12α BA/non-12 BA in feces is closely associated with hepatic triacylglycerol accumulation in B6 mice fed HF diet.
Destruction of mesoscopic chemically modulated domains in single phase high entropy alloy via plastic deformation
Authors: Miyajima Yoji , Nagata Tomohiro , Takeda Kohei , Yoshida Shuhei , Yasuno Satoshi , Watanabe Chihiro , Kazuhiro Ishikawa , Adachi Hiroki , Tsuji Nobuhiro 
Published: October 2022

AbstractChemically modulated mesoscopic domains in a fcc single phase CrMnFeCoNi equi-atomic high entropy alloy (HEA) are detected by small angle diffraction performed at a synchrotron radiation facility, whereas the mesoscopic domains cannot be detected by conventional X-ray diffraction and 2D mappings of energy dispersive X-ray spectroscopy by scanning electron microscopy and scanning transmission electron microscopy. The mesoscopic domains are deformed and shrieked, and finally destructed by plastic deformation, which is supported by the comprehensive observations/measurements, such as electrical resistivity, Vickers hardness, electron backscattering diffraction, and hard X-ray photoemission spectroscopy. The destruction of the mesoscopic domains causes the decrease in electrical resistivity via plastic deformation, so called K-effect, which is completely opposite to the normal trend of metals. We confirmed that the presence and the size of local chemical ordering or short-range order domains in the single phased HEA, and furthermore, Cr and Mn are related to form the domains.
Nonlinear effects in Thomas precession due to the interplay of Lorentz contraction and Thomas–Wigner rotation
Authors: Di Lorenzo Antonio 
Published: October 2022

AbstractIt is demonstrated that the 3-vector $$\varvec{S}$$

S

currently associated to the spin in an inertial frame does not contract, but rather dilates, in the direction of the velocity. The correct vector $$\varvec{T}$$

T

is individuated. The equation of motion for the two vectors is shown to contain two terms, a common linear rotation, identified with Thomas precession, and also a nonlinear rotation depending on the direction of the spin itself.
Reduction of stress responses in honey bees by synthetic ligands targeting an allatostatin receptor
Authors: Sánchez-Morales Adrià , Gigoux Véronique , Matsoukas Minos-Timotheos , Perez-Benito Laura , Fourmy Daniel , Alibes Ramón , Busqué Félix , Cordomí Arnau , Devaud Jean-Marc 
Published: October 2022

AbstractHoney bees are of great economic and ecological importance, but are facing multiple stressors that can jeopardize their pollination efficiency and survival. Therefore, understanding the physiological bases of their stress response may help defining treatments to improve their resilience. We took an original approach to design molecules with this objective. We took advantage of the previous identified neuropeptide allatostatin A (ASTA) and its receptor (ASTA-R) as likely mediators of the honey bee response to a biologically relevant stressor, exposure to an alarm pheromone compound. A first series of ASTA-R ligands were identified through in silico screening using a homology 3D model of the receptor and in vitro binding experiments. One of these (A8) proved also efficient in vivo, as it could counteract two behavioral effects of pheromone exposure, albeit only in the millimolar range. This putative antagonist was used as a template for the chemical synthesis of a second generation of potential ligands. Among these, two compounds showed improved efficiency in vivo (in the micromolar range) as compared to A8 despite no major improvement in their affinity for the receptor in vitro. These new ligands are thus promising candidates for alleviating stress in honey bees.
Performance of a solar photocatalysis reactor as pretreatment for wastewater via UV, UV/TiO2, and UV/H2O2 to control membrane fouling
Authors: Ali Nisreen S. , Kalash Khairi R. , Ahmed Amer N. , Albayati Talib M. 
Published: October 2022

AbstractThe performance of a solar photocatalysis reactor as pretreatment for the removal of total organic carbon (TOC) and turbidity from municipal wastewater was achieved by implementing an integrated system as tertiary treatment. The process consisted of ultraviolet (UV) sunlight, UV sunlight/H2O2, and UV sunlight/TiO2 nanocatalysts as pretreatment steps to prevent ultrafiltration (UF) membrane fouling. The characterization of TiO2 was conducted with X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy , and Brunauer–Emmett–Teller surface area analysis. This study investigated the effect of time and solar radiation using UV, UV/H2O2, and UV/TiO2 to remove TOC and turbidity. The transmembrane pressure improvement was studied using a UF membrane system to pretreat wastewater with different UV doses of sunlight for 5 h and UV/H2O2 and UV/TiO2. The results showed that the highest removal efficiency of the turbidity and TOC reached 95% and 31%, respectively. The highest removal efficiency of the turbidity reached 40, 75, and 95% using UV, UV/H2O2, and UV/TiO2, respectively, while the optimal removal efficiency of TOC reached 20%, 30%, and 50%, respectively.
Compression-induced improvements in post-exercise recovery are associated with enhanced blood flow, and are not due to the placebo effect
Authors: O’Riordan Shane F. , Bishop David J. , Halson Shona L. , Broatch James R. 
Published: October 2022

AbstractThe aim of this study was to investigate the physiological effects of compression tights on blood flow following exercise and to assess if the placebo effect is responsible for any acute performance or psychological benefits. Twenty-two resistance-trained participants completed a lower-body resistance exercise session followed by a 4 h recovery period. Participants were assigned a post-exercise recovery intervention of either compression tights applied for 4 h (COMP), placebo tablet consumed every hour for 4 h (PLA) or control (CON). Physiological (markers of venous return, muscle blood flow, blood metabolites, thigh girth), performance (countermovement jump, isometric mid-thigh pull), and psychological measures (perceived muscle soreness, total quality of recovery) were collected pre-exercise, immediately post-exercise, at 30 (markers of venous return and muscle blood flow) and 60 min (blood metabolites, thigh girth and psychological measures) intervals during 4 h of recovery, and at 4 h, 24 h and 48 h post-exercise. No significant (P > 0.05) differences were observed between interventions. However, effect size analysis revealed COMP enhanced markers of venous return, muscle blood flow, recovery of performance measures, psychological measures and reduced thigh girth compared to PLA and CON. There were no group differences in blood metabolites. These findings suggest compression tights worn after resistance exercise enhance blood flow and indices of exercise recovery, and that these benefits were not due to a placebo effect.