bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Evaluation of New Derivatives of Busulfan as an Anti-carcinogenic Drug against k562 Cancer Cells Using the AO / PI Method
Authors: Jabbari Hadi , Khosravi Setareh , Azimi Saeid 
Published: October 2022

Background:
Busulfan is a DNA alkylating drug used to treat chronic myeloid leukemia (CML). This type of leukemia affects bone marrow cells or myocytes, which make up bone marrow tissue having a chronic process. Leukemia is a progressive and malignant disease of the body's hematopoietic organs. The disease is caused by the underdevelopment and proliferation of white blood cells and their precursors in the blood and bone marrow.

Objective:
The synthesis of Busulfan drug and the conjugation of Busulfan from the anomeric position of acetylated galactose as a new derivative of Busulfan and its anti-cancer effect on K562 cancer cells are among the most important objectives of this study.

Methods:
In this work, galactose was acetylated with acetic anhydride in the presence of sodium acetate, then the anomeric position of acetylated carbohydrate deacetylated using imidazole to obtain the final product through the reaction of Busulfan. Anti-cancer activity of the product was evaluated against K562 cancer cells. The proliferation and survival of K562 cancer cells and PBMCs (peripheral blood mononuclear cells) using the AO/PI method were studied. Furthermore, 1- (2, 3, 4, 6-tetra-O-acetyl-Iβ-D-galactopyranosyl) -4- (methyl sulfonyl oxy) butane was evaluated against cancer cells as a new derivative.

Results:
In this study, the Acridine Orange / Propidium Iodide (AO/PI) method was performed using fluorescence microscopy to evaluate the efficacy of a synthesized product. The effective dose of 0.02 mg/L of 1- (2, 3, 4, 6-tetra-O-acetyl-Iβ-D-galactopyranosyl) -4- (methyl sulfonyl oxy) butane was observed to cause 96% of cancer cells necrosis.

Conclusion:
1- (2, 3, 4, 6-tetra-O-acetyl-Iβ-D-galactopyranosyl) -4- (methyl sulfonyl oxy) butane as a new derivative of Busulfan acts non-specifically in the cell cycle by inhibiting DNA activity by alkylation and binding to the DNA strand. Alkylating agents usually bind an alkyl group to the number seven nitrogen atom in the guanine nucleotide in a DNA molecule.
Organoselenium Compounds as Potential Therapeutic Agents for Treating
Brain Disorders
Authors: Kothapalli Lata , Sarode Varsha , Thomas Asha , Bhole Ritesh 
Published: October 2022

Abstract:
Among the inorganic elements, selenium is one of the essential entities required in trace amounts. Selenium (Se) has a vital role to play in brain physiology. It is well demonstrated that an abnormal level of selenium is the cause of the pathogenesis of various neurodegenerative diseases. As selenium levels are age-dependent, deficiency of Se is well correlated with cognitive disability with aging which further correlates with Alzheimer’s disease. Organoselenium compounds are considered an essential therapeutic class of compounds as they have gained a wide spectrum of applications in biotransformation and are well-studied by several researchers. In recent years, a detailed analysis of the effectiveness of organoselenium compounds in attenuating disease are done. A literature search on PubMed, Embase, and Scopus databases was done using the keywords “organoselenium compounds, brain disorder, Alzheimer's, Parkinson's' disease, neurodegenerative disorders. The introduction of selenium as a functional group in aryl and heteroaryl compounds has given the lead for treating various brain ailments including Alzheimer's disease, depression, anxiety, Parkinson’s disease, etc. The organoselenium compounds are also potent antioxidants and are promising chemical entities for further studies.
PENERAPAN SEAMLESS TUCKS PADA BUSANA PESTA WANITA DAN PRIA DENGAN TEMA THE GRAY HOLE
Authors: Indarti Indarti , Putri Aprillia Anggi Wati 
Published: October 2022

Tujuan penelitian adalah untuk mengetahui proses pembuatan dan hasil jadi semless tucks pada busana pesta wanita dan pria dengan tema the gray hole. Metode yang digunakan adalah three stage design process (LaBat Sokolowski, 1999), yang terdiri dari 3 tahapan yaitu problem definition research, creative exploration, dan implementation. Dari hasil yang diperoleh, seamless tucks bisa digunakan sebagai detail busana pesta baik untuk wanita maupun pria. Proses pembuatan seamless tucks menggunakan jahitan tangan (tusuk jelujur) dengan mengikuti pola yang telah digambar atau dijiplak pada permukaan kain. Adanya lipatan kain yang dijahit dalam membentuk seamless tucks, maka diperlukan penambahan lebar dan panjang kain, untuk motif yang penuh diperlukan dua kali panjang dan lebar kain. Hasil jadi pada busana wanita sesuai dengan konsep perancangan antara lain menggunakan siluet H, penerapan seamless tucks berbentuk lingkaran menyerupai lubang pori-pori pada batu apung diterapkan pada keseluruhan permukaan cape dan menjadi center of interest dari keseluruhan look pada gaun pesta. Hasil jadi pada busana pria sesuai dengan konsep perancangan yaitu menggunakan siluet busana formal yang klasik berupa setelan jas (suit). Penerapan seamless tucks berbentuk lingkaran diterapkan pada kelepak kerah (peak lapel) dan kelepak saku. Hasil jadi busana secara keseluruhan telah memenuhi beberapa kriteria prinsip desain.
SEKSUALITAS PEREMPUAN DAN WACANA DOMINAN PATRIARKI DALAM BEAUTIFUL YOU KARYA CHUCK PALAHNIUK
Authors: Dinanti Putri Ayienda , Tjahjani Joesana 
Published: October 2022

Patriarki adalah salah satu sistem sosial yang mengatur di beberapa negara. Imbas dari sistem patriarki, perempuan sering mengalami dominasi dan tekanan yang ditimbulkan oleh laki-laki. Hal tersebut dilakukan melalui penguasaan terhadap seksualitas perempuan. Mengacu pada latar belakang tersebut, penelitian ini bertujuan mengungkap hubungan seksualitas perempuan dengan wacana patriarki di dalam karya sastra, khususnya novel Beautiful You. Karya tersebut ditulis oleh Chuck Palahniuk di tahun 2014 dan termasuk ke dalam jajaran sastra kontemporer Amerika. Metode berlandaskan kualitatif dipilih ke dalam penelitian untuk mendapatkan gambaran analisis yang lebih rinci. Tulisan ini menggunakan pendekatan struktural dan kritik sastra feminis. Teori sekuen Schmitt dan Viala, serta bagan fungsional transformasi Greimas digunakan untuk membongkar struktur dan strategi naratif teks. Teori feminisme eksitensialis milik Beauvoir kemudian dipaparkan untuk menemukan ideologi dalam teks. Hasil penelitian menunjukkan bahwa: pertama, struktur teks dan strategi naratif memang mengindikasikan kehadiran dominasi laki-laki di sepanjang cerita. Kedua, laki-laki mendominasi melalui tubuh dan seksualitas perempuan. Ketiga, dominasi tersebut berhubungan erat dengan adopsi wacana patriarki yang kemudian menjadi ideologi dalam teks. Kata kunci: dominasi, kesusastraan, patriarki, perempuan, seksualitasWOMEN’S SEXUALITY AND DOMINANT DISCOURSE OF PATRIARCHY IN BEAUTIFUL YOU BY CHUCK PALAHNIUK AbstractPatriarchy is one of the social systems that governs in several countries. As a result of the patriarchal system, women often experience domination and pressure caused by men. This is done through domination of women's sexuality. Referring to this background, this study is aimed at revealing the relationship between women's sexuality and patriarchal discourses in literary works, especially in the novel Beautiful You. The work is written by Chuck Palahniuk in 2014 and belongs to the ranks of contemporary American literature. A qualitative based method is selected in the study to obtain a more detailed description of the analysis. The study uses a structural approach and feminist literary criticism. Schmitt and Viala's sequence theory, as well as Greimas’ transformation functional chart are used to unravel the text structure and narrative strategy. Beauvoir's theory on existentialist feminism is presented to find ideologies in the text. The results of the research show that: first, the structure of the text and the narrative strategy indeed indicate the presence of male dominance throughout the story. Second, men dominate through women's bodies and sexuality. Third, that dominance is closely related to the adoption of patriarchal discourses which later become an ideology in the text. Keywords: domination, literature, patriarchy, women, sexuality
Multi-strain disease dynamics on metapopulation networks
Authors: Michalska-Smith Matthew , VanderWaal Kimberly , Torremorell Montserrat , Corzo Cesar , Craft Meggan E 
Published: October 2022

A much-updated version of this work is now available published
open-access at Scientific
Reports: https://www.nature.com/articles/s41598-022-12774-5

Many pathogens have clusters of variation in their genotypes that we
refer to as strain structure. Importantly, when considering related
pathogen strains, host immunity to one strain is often neither
independent from nor equivalent to immunity to other strains. This
partial cross-reactive immunity can thus allow repeated infection with
(different strains of) the same pathogen and shapes disease dynamics
across a population, in turn influencing the effectiveness of
intervention strategies. To better understand the dynamics governing
multi-strain pathogens in complex landscapes, we combine two frameworks
well-studied in their own right: multi-strain disease dynamics and
metapopulation network structure. We simulate the dynamics of a
multi-strain disease on a network of populations connected by migration
and characterize the joint effects of disease model parametrization and
network structure on these dynamics. We find that the movement of
(partially) immune individuals tends to have a larger impact than the
movement of infectious individuals, dampening infection dynamics in
populations further along a chain. When disease parameters differ
between populations, we find that dynamics can propagate from one
population to another, alternatively stabilizing or destabilizing
destinations populations based on the dynamics of origin populations. In
addition to providing novel insights into the role of host movement on
disease dynamics, this work provides a framework for future predictive
modelling of multi-strain diseases across generalized population
structures.
Kualitas Pelayanan Pramusaji di Muaro Terrace Cafe Hotel Truntum Padang
Authors: Syukri Finana , Asnur Lise 
Published: October 2022

Penelitian ini dilakukan dengan tujuan untuk mendeskripsikan kualitas pelayanan pramusaji di Muaro Terrace Cafe Hotel Truntum Padang. Penelitian ini dilatar belakangi karena adanya pelayanan yang diberikan pramusaji yang tidak disenangi oleh tamu. Jenis penelitian yang digunakan yaitu deskrptif kuantitatif dengan metode survey dengan jumlah responden sebanyak 97 orang tamu Muaro Terrace Cafe. Teknik data yang digunakan dalam pengambilan sampel adalah non probability sampling dengan jenis penelitian insidental sampling. Hasil penelitian yang dilakukan, maka disimpulkan bahwa variabel kualitas pelayanan pramusaji di Muaro Terrace Cafe secara keseluruhan dapat digolongkan pada kategori sangat tidak baik dengan skor tingkat capaian responden TCR 68,965% dengan kategori Baik. Ditinjau dari indikator tangible memperoleh skor TCR sebesar 421 % dengan kategori sangat tidak baik, indikator empathy memperoleh TCR sebesar 559% dengan kategori sangat tidak baik, indikator responsiveness memperoleh skor TCR sebesar 432% dengan kategori kurang baik, indikator reliability memperoleh TCR sebesar 581% dengan kategori sangat tidak baik, indikator assurance memperoleh skor TCR sebesar 269% dengan kategori cukup baik.
Pengaruh Fasilitas Wisata Terhadap Kepuasan Pengunjung di Daya Tarik Wisata Pantai Air Bangis Pasaman Barat
Authors: Hamidah  
Published: October 2022

Daya tarik wisata pantai air bangis ini yaitu belum terdapatnya tempat sampah di sekitar daya tarik wisata yang mengakibatkan banyaknya penumpukan sampah di sekitar pantai sehingga pengunjung yang datang merasa tidak nyaman dengan kondisi pantai yang kotor, masalah berikutnya adalah fasilitas umum seperti toilet sangat kotor di kawasan daya tarik wisata pantai air bangis, tidak tersedianya sarana transportasi umum untuk mencapai lokasi daya tarik wisata, dan juga toko souvenir belum ada di kawasan daya tarik wisata ini. Tujuan dari penelitian ini adalah untuk menganalis pengaruh Fasilitas Wisata Terhadap Kepuasan Pengunjung di Daya Tarik Wisata Pantai Air Bangis Pasaman Barat. Penelitian ini menggunakan metode kuantitatif dengan pendekatan asosiatif bentuk hubungan kausal dengan total sampel sebanyak 100 orang. Penelitian ini terdiri dari dua variabel yaitu Fasilitas wisata Variabel (X) dan Kepuasan Pengunjung Variabel (Y) penelitian ini menggunakan teknik analisis data berupa persentase dengan pengkategorian terbagi menjadi 5 kategori yaitu kategori sangat baik, kategori baik, kategori cukup baik, kategori buruk dan kategori sangat buruk Hasil dari penelitian yang telah dilakukan diperoleh hasilnya berupa fasilitas wisata termasuk ke dalam kategori sangat baik (50% ) dan kepuasan pengunjung termasuk ke dalam kategori buruk (55%).
Pengaruh Kompetensi, Disiplin dan Kompensasi Terhadap Kinerja Petugas Lapangan Keluarga Berencana Non PNS dalam Pelaksanaan Program Bangga Kencana
Authors: Ni Putu Setiawati  
Published: October 2022

Saat ini tingkat capaian kinerja/keberhasilan pelaksanaan program Bangga Kencana masih belum sesuai target. Analisis awal menunjukkan bahwa beberapa faktor yang mempengaruhi hal tersebut adalah kompetensi, disiplin dan kompensasi yang diperoleh, berdaasarkana hal tersebut penelitian yang bertujuan untuk menganalisis kompetensi, disiplin dan kompensasi terhadap kinerja petugas lapangan keluarga berencana (PLKB) non PNS dalam pelaksanaan program bangga kencana. Penelitian ini merupakan penelitian asosiatif kausal dengan menggunakan pendekatan kuantitatif. Populasi dalam penelitian ini PLKB Non PNS pada DPPKBPPPA sebanyak 115 orang dan seluruh populasi dijadikan sampel penelitian. Metode pengumpulan data dan instrumen yang digunakan dalam penelitian ini menggunakan kuesioner, dan observasi untuk memperoleh data kompetensi, disiplin, kompensasi dan kinerja PLKB Non PNS. Metode analisis data yang digunakan adalah metode analisis diskriptif dan analisis mutiregresi menggunakan bantuan SPSS 26.00. Hasil penelitian menunjukkan bahwa secara parsial tidak ada pengaruh variabel kompetensi terhadap kinerja PLKB Non PNS, tidak ada pengaruh antara variabel disiplin secara parsial terhadap variabel kinerja PLKB Non PNS dan ada pengaruh variabel kompensasi secara parsial terhadap kinerja PLKB Non PNS.
Strategi Pengembangan Sumber Daya Manusia
Authors: Kumala Desiana Astika Ratna 
Published: October 2022

Belum meratanya pendidik dan tenaga kependidikan, baik secara kuantitas maupun kualitas. Belum memadainya ketersediaan fasilitas belajar dan prasarana penunjang termasuk peralatan peraga pendidikan. Belum optimalnya sistem kendali mutu dan jaminan kualitas pendidikan, dan belum tersedianya biaya operasional yang diperlukan untuk pelaksanaan proses belajar mengajar secara bermutu. Penelitian ini menganalisis pemetaan SDM STAHN Mpu Kuturan Singaraja khususnya pada tataran implementasinya dalam mempersiapkan lembaga pendidikan tinggi Hindu ini berubah status. Metode yang digunakan dalam penelitian ini adalah kualitatif. Metode ini mi mencoba menguraikan secara naratif dan eksploratif terhadap strategi pengembangan SDM yang dilakukan. Adapun subjek penelitian dalam penelitian ini yakni dosen dan pegawai yang berjumlah 20 orang. Teknik pengumpulan data menggunakan metode wawancara, dokumen, observasi dan wawancara secara langsung. Analisis data menggunakan model Miles and Huberman (1984) yakni data reductions, data display dan conclusion drawing/verification. Hasil penelitian yakni pemetaan SDM sudah baik hal tersebut tercermin dari komposisi atau rasio dosen maupun pegawai dengan mahasiswa. Kompetensi SDM belum optimal dan kualitas kerja cukup produktif, masih ditemui penempatan SDM tidak sejalan dengan latar belakang kualifikasi dan kompetensi saat dilakukan rekrutmen melalui CPNS. Strategi pengembangan SDM dengan melakukan langkah pemetaan dan rekrutmen sesuai kualifikasi, peningkatan kualitas, pengembangan jenjang karir, memberikan penghargaan dan peningkatan kualitas kerja yang kondusif dan nyaman.
Um estudo sobre comunicação remota a partir da ideia de precognição
Authors: Francisco do Nascimento Flávio 
Published: October 2022

Em meados do séc. XX, precisamente durante a guerra fria, houve um grande desenvolvimento de tecnologias de comunicação remota de modo que os impérios, soviético e Estado Unidense, pudessem vigiar um ao outro à distância garantindo a eles expansão e segurança político-militares. Aquele desenvolvimento esteve inextricavelmente ligado às correntes teóricas, matemática e sistêmica, que concorreram para a consolidação científica das
ciências da informação. Sugerimos que essas mesmas correntes foram utilizadas como possibilidades de explicar o mecanismo parapsicológico da precognição, mecanismo esse que diz respeito ao conhecimento antecipado de informações e que foi objeto do debate dos artigos que analisamos. E sobre esse debate, apresentamos indícios de que a precognição toma sua forma concreta à medida que as ideias, bem como o implemento das tecnologias de informação se consolidam como instrumentos intencionais de poder e controle do comportamento social através da comunicação remota.
capital financeiro e o combate às ações climáticas: a coexistência necessária
Authors: Camargo Bisneto Eduardo L. de 
Published: October 2022

O mundo passa por constantes transformações e, consequentemente, evoluções melhorando o bem-estar social. Mas, para que essas evoluções continuem ocorrendo é necessário parar um pouco e entender o processo. Reflexões como: Recursos naturais são finitos, será que o consumo de hoje não influencia o consumo futuro? Será que não as ações de hoje não vou impactar as gerações futuras? A forma que consumimos hoje é sustentável a médio longo prazo? Essas são algumas perguntar as quais já temos a resposta. Não, se continuarmos consumindo e tratando o meio ambiente da forma que tratamos nós não vamos ter mais recursos e o impacto para as gerações futuras será severo. A discussão citada acima não é nova, dessa maneira, vê-se a discussão desde século 19 com Thomas Malthus e Marques de Condorcet que permanece até hoje nas pautas dos principais governantes, chefes de Estado e instituições internacionais. O presente artigo apresenta uma contextualização da discussão sobre recursos naturais e as implicações para as gerações futuras assim como, apresenta o que tem se tem de mais recente nas discussões governamentais, trazendo de forma clara e objetiva a responsabilidade para os Governos de Estado, sem eximir o capital financeiro da responsabilidade de peça fundamental para o combate as ações climáticas.
Sustainability reporting and firm value
Authors: Putri Negina Kencono , Masrurin Khoirul 
Published: October 2022

Environment has become an important issue in the business world these days. Companies are increasingly paying more attention to company management without neglecting environmental sustainability. This study aims to examine the effect of sustainability reports for on stock performance, with growth category companies as the moderating variable. The sample consist of 18 growth-category companies that were included in the evaluation during 2020 in Indonesian Stock Exchange. The sustainability report is an indicator for environmental performance taken from compliance with Global Reporting Initiative (GRI) Standards, while stock performance is measured using the share price at the reporting date. Tests are carried out using Moderated Regression Analysis. The results showed that a growth category company that had a good environmental performance also had a good stock performance. And when compared with the performance of companies that are included in the non-growing category, there is a difference, although not statistically significant. This implies the importance of companies and investors to pay attention to environmental performance reporting and processes in accordance with environmental performance reporting standards.
Employee Acceptance of E-Health and Its Implication for Performance in Specialist Hospitals in Ondo State, Nigeria
Authors: Ajayi Modupe Olayinka , Abasilim Angela Nneka , Adejumo David D. 
Published: October 2022

The study examined e-health (ICT) acceptance on employee performance in Ondo State specialist hospitals. The study investigated the challenges facing acceptance of e-health by employees of state specialist hospitals and also examined the effect of acceptance of e-health on the performance of employees in state specialist hospitals. The purpose was to access how ehealth can help improve service delivery in teaching hospitals in the study area. The work is anchored on the Technology Acceptance Model (TAM) which is an adoption model focusing on users’ acceptance of information systems or computer technologies. The aim of this theory is to describe factors that determine technology acceptance and information technology usage behavior. Primary data was used for the study. The questionnaire was used for the collection of data. The number of respondents for the study is 318. Descriptive and inferential statistics were used for data analysis. The research findings using descriptive analysis showed that a lot of challenges exist and affect the degree of acceptance of e-health by the employees in the study area. The result also showed that e-health (ICT) acceptance has a positive significant effect on employee performance in the state specialist hospitals in the study area. The hypothesis stated was tested at a 0.05 level of significance to determine the effect of e-health acceptance on employees’ performance using regression analysis and it was rejected because the pvalue was less than 0.05 (Beta=0.208, t=7.149, Sig=0.000, p<0.05). The study, therefore, concludes that there are challenges that affect the acceptance of ehealth (ICT) and that there is a significant positive effect of e-health acceptance and performance of employees in the state specialist hospitals in Ondo State, Nigeria.
Online Recruitment Processes, Online Selection and Human Resources Development: A Significant Influence on Quality of Health Personnel
Authors: Sartika Widya , Hilmy Mohamad Reza , Mulyani Erry Yudhya 
Published: October 2022

Background and Purpose Health workers are the main key to the success of achieving health development goals. As a very decisive first step for the availability of qualified health workers, the recruitment and selection process for health workers and the development of human resources is carried out. The purpose of this study was to analyze the effect of the recruitment, selection, and development of human resources together or partially on the quality of work of health workers at Citra Sundari Hospital. Method; The research method used is a quantitative approach with an associative correlation type. The population of this study was all health workers at Citra Sundari Hospital. The sample of this study was 80 health workers. The proposed hypothesis has an influence on the recruitment process, a system of selection and development of human resources independently or jointly on the quality of work of health workers. Results; The process of recruitment, selection, and development of human resources together partially affect the quality of work of health workers at Citra Sundari Hospital. Implications; The results of this study provide direction and input related to the recruitment, selection, and development of human resources so that hospitals have quality health workers.