bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing inhibitory control in the real world is virtually possible: a virtual reality demonstration
Authors: Rocabado Francisco , Duñabeitia Jon Andoni 
Published: October 2022

Abstract
Executive functions are the key ingredient for behavior regulation. Among them, Inhibitory control is one of main exponents of executive functions, and in the last decades it has received a good amount of attention thanks to the development of chronometric tasks associated with paradigms that allowed exploring human behaviour when the inhibitory component is needed. Among the different paradigms typically used, the Simon and flanker tasks are probably the most popular ones. These have been subjected to modifications in order to assess inhibitory control from different perspectives (e.g., in different samples, or in combination with different research techniques). However, its use has been relegated to classical presentation modalities within laboratory settings. The accessibility of virtual reality (VR) technology has opened new research avenues to explore research on inhibition control assessment with increased ecological validity, still ensuring laboratory-like controlled conditions and high precision in the measurements. Relying on this technology, here we present two state-of-the-art adaptations of the classical Simon and flanker tasks reinterpreted and adapted to real-world circumstances. Our results show that VR is a reliable tool to assess inhibitory control that could provide valid experimental data with a high level of real-world transferability and generalizability.
Empowering Catchment Health Center to Deliver A Comprehensive Obstetric Care Near Home: An Institutional Experience from Ethiopia
Authors: Kebede Dawit , Adem Abdu , Anteneh Dagmawi 
Published: October 2022

Abstract
Background: Nearly all maternal complications that result in three-quarters of maternal deaths can be prevented by proper emergency referral procedures, early recognition of obstetric complications, and timely and adequate care. But, many women still face setbacks in timely accessing emergency obstetric interventions that will save their life.
Aim: This project aimsto establish and deliver comprehensive emergency obstetric care at the highest referring catchment health center to St. Paul’s Hospital Millennium Medical College (SPHMMC) over a period of 16 months (from December 2020 to April 2022).
Methods: A pre and post-intervention follow-up study design was employed to evaluate the impact of establishing and supporting a health center on the access and quality of maternal service. After identifying a highly referring catchment health center, we established a multidisciplinary team (MDT) responsible for preparing a readiness plan, facilitating staff training on comprehensive emergency obstetric care, resource mobilization, and continuous supportive supervision.
Result:Caesarian section delivery, holistic obstetric ultrasound service, comprehensive abortion care, and antenatal care service were started. The total monthly delivery at Anne Dimma health center almost quadrupled from a baseline of 94 to an average of 334, referral out from the health center to SPHMMC decreased from a baseline of 156 mothers to a median of 12, and increased maternal emergency referral-in to Anne Dimma health center from the surrounding health center from zero to a median of 42.5. The total number of deliveries at SPHMMC decreased from a monthly average of 902 to a monthly average of 827 over the project period.
Conclusion: Delivering comprehensive emergency obstetric care near the client’s home by empowering the catchment health center has a significant role in reducing unnecessary referrals and costs, overcrowding of tertiary hospitals, and increasing antenatal and postnatal care attendance and institutional delivery.
Evaluation of the immunization effectiveness of a bOPV booster immunization at 48 months of age after basic polio sequential immunization with bOPV and IPV
Authors: Yang Jingsi , zhao Yuping , Li Jing , Huang Teng , Huang Teng , Zhao Ting , Che Yanchun , Zhao Zhimei , Fu Yu ting , Tao Jun hui , Yang Qing hai , Wei Ding kai , Li Guoliang , Yang Xiaolei , Yi Li , Chen Hongbo , Wang Jianfeng , Jiang Ruiju , Yu Lei , Cai Wei , Yang Wei , Xie Ming xue , Yin Qiongzhou , Pu Jing , Shi Li , Hong Chao , Deng Yan , Cai Lukui , Zhou Jian , Wen Yu , Li Hong sen , Huang Wei , Mo Zhao jun , Li Qihan 
Published: October 2022

Abstract
To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV) at 48 months of age after different primary polio immunization schedules. At 48 months of age, one dose of bOPV was administered, and their poliovirus types 1–3 (PV1, PV2, and PV3, respectively)-specific neutralizing antibody levels were determined. Participants found to be negative for any type of PV-specific neutralizing antibody at 24, 36, or 48 months of age were re-vaccinated with inactivated polio vaccine (IPV). The 439 subjects who received a bOPV booster immunization at the age of 48 months had lower PV2-specific antibody levels compared with those who received IPV. One dose of IPV during basic polio immunization induced the lowest PV2-specific antibody levels. On the basis of our findings, to ensure that no less than 70% of the vaccinated have protection efficiency, we recommend the following: if basic immunization was conducted with 1IPV + 2bOPV (especially Sabin strain-based IPV), a booster immunization with IPV is recommended at 36 months of age, whereas if basic immunization was conducted with 2IPV + 1bOPV, a booster immunization with IPV is recommended at 48 months of age. A sequential immunization schedule of 2IPV + 1bOPV + 1IPV can not only maintain high levels of antibody against PV1 and PV3 but also increases immunity to PV2 and induces early intestinal mucosal immunity, with relatively good safety. Thus, this may be the best sequential immunization schedule for polio in countries or regions at high risk for polio.
Effect of dietary Bacillus subtilis supplement on Cd toxicokinetics and Cd-induced immune and antioxidant impairment of Procambarus clarkii
Authors: Dai Caijiao , Xiao Lin , Mo Aijie , Yuan Yongchao , Yuan Junfa , Gu Zemao , Wang Jianghua 
Published: October 2022

Abstract
Cadmium (Cd), a non-biodegradable contaminant in freshwater ecosystems, can pose a serious threat to aquatic animals at high levels. In this study, the Cd toxicokinetics and the immune and antioxidant defense were explored after the crayfish exposed to different levels of Cd (0, 0.1, 1.0 mg Cd/L) or treated with 1.0 mg Cd/L and dietary Bacillus subtilis supplementation (1 x 107 cfu/g). Results from the 21-day uptake and depuration experiment revealed that Cd exposure elicited a dose-and time-dependent uptake in all crayfish tissues, and the rank order of Cd concentration was: gill > hepatopancreas > exoskeleton > muscle. The two-compartment model demonstrated that gills had the highest ku value after Cd aqueous exposure and the ku and kd values in gill, hepatopancreas, and exoskeleton of the group with 1.0 mg Cd/L were higher than those of the group with low Cd concentration (0.1 mg Cd/L). However, B. subtilis could increase Cd ku and decrease Cd kd in hepatopancreas, resulting in the reduction of BCF, Css and Tb1/2. A positive correlation was found between aqueous Cd concentration and the severity of hepatopancreas histopathological injury, while B. subtilis could ameliorate the pathological damage in the high Cd group. Similarly, Cd aqueous exposure elevated malonaldehyde (MDA) content and suppressed the activities of lysozyme (LZM), acid phosphatase (ACP) and alkaline phosphatase (AKP) in hemolymph. The activities of superoxide dismutase (SOD) and catalase (CAT) in hepatopancreas were also inhibited. Nevertheless, they were all recovered with the dietary addition of B. subtilis. In conclusion, our results indicated that exposure to Cd significantly increased Cd accumulation and toxic damages in crayfish hepatopancreas, while dietary administration of B. subtilis to crayfish significantly decreased Cd accumulation and improved the immune and antioxidant defense, leading to the prevention in toxic effects of Cd.
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
Authors: Liu Li , Han Shanshan , Xiao Xi , An Xuefeng , Gladkich Jury , Hinz Ulf , Hillmer Stefan , Hoppe-Tichy Torsten , Xu Yi , Schäfer Michael , Strobel Oliver , Herr Ingrid 
Published: October 2022

AbstractGlucocorticoids (GCs) are widely used in tumor therapy to reduce tumor growth, inflammation, edema, and other side effects. Controversially, GCs may also cause the progression of epithelial tumors involving highly aggressive pancreatic ductal adenocarcinoma (PDAC). Because microRNA (miR) and autophagy signaling support the invasive growth of PDAC, we asked whether these mechanisms may be targeted by GCs. Six established human PDAC cell lines, tissue from patients who received GC medication (n = 35) prior to surgery, or not (n = 35), and tumor xenografts were examined by RT‒qPCR, transmission electron microscopy (TEM), monodansylcadaverine (MDC) staining, immunohistochemistry,in situhybridization, gene array and Kaplan‒Meier analysis with bioinformatics, and MTT, western blot, colony, spheroid, migration, and invasion assays. We found that various GCs, including dexamethasone (DEX), induced typical features of macroautophagy with the appearance of autolysosomes, enhanced LC3-II, decreased SQSTM1/p62 expression and induced epithelial-mesenchymal transition (EMT) and gemcitabine resistance. The GC receptor (GR) antagonist mifepristone (RU486) counteracted DEX-induced autophagy features, suggesting that the GC-GR complex is involved in the induction of autophagy. The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival. siRNA-mediated downregulation of miR-378 inhibited DEX-induced autophagy, colony and spheroid formation, wound healing, invasion, migration, and tumor progression. Bioinformatics confirmed the contribution of miR-378 to the regulation of signaling networks involved in GC-induced autophagy and tumor progression. The construction of a molecular docking model revealed stable binding of miR-378 to the DEX-GR complex, suggesting direct regulation. These substantial, novel, in-depth data reveal that GCs favor autophagy-mediated cancer progression by inducing miR-378 and GR binding and implicate GR and miR-378 as new therapeutic targets.
Photonic p-orbital higher-order topological insulators
Authors: Zhang Yahui , Bongiovanni Domenico , Wang Ziteng , Wang Xiangdong , Xia Shiqi , Hu Zhichan , Song Daohong , Jukić Dario , Xu Jingjun , Morandotti Roberto , Buljan Hrvoje , Chen Zhigang 
Published: October 2022

Abstract
The orbital degrees of freedom play a pivotal role in understanding fundamental phenomena in solid-state materials as well as exotic quantum states of matter including orbital superfluidity and topological semimetals. Despite tremendous efforts in engineering synthetic cold-atom, as well as electronic and photonic lattices to explore orbital physics, thus far high orbitals in an important class of materials, namely, the higher-order topological insulators (HOTIs), have not been realized. Here, we demonstrate p-orbital corner states in a photonic HOTI, unveiling their underlying topological invariant, symmetry protection, and nonlinearity-induced dynamical rotation. In a Kagome-type HOTI, we find that the topological protection of p-orbital corner states demands an orbital-hopping symmetry, in addition to the generalized chiral symmetry. Due to orbital hybridization, the nontrivial topology of the p-orbital HOTI is “hidden” if bulk polarization is used as the topological invariant, but well manifested by the generalized winding number. Our work opens a pathway for the exploration of intriguing orbital phenomena mediated by higher band topology applicable to a broad spectrum of systems.
Multimodal physical exercise and functional rehabilitation program in oncological patients with cancer-related fatigue. A randomized clinical trial
Authors: Rodriguez Eduardo Jose Fernandez , Gomez Celia Sanchez , Hernandez Juan Jesus Cruz , Rodriguez Jose Ignacio Recio , Gonzalez Ana Silvia Puente , Sanchez Roberto Mendez , Galve Maria Isabel Rihuete , Sanchez Jesus Gonzalez 
Published: October 2022

Abstract
Background

The increase in life expectancy and survival time implies an increase in the possible side-effects of pharmacological treatments in these patients. Cancer-related fatigue is one of them. The main objective of this study is to evaluate the effects of a multimodal program of physical exercise and functional rehabilitation on asthenia, pain, functional capacity and quality of life in cancer patients with cancer-related fatigue.

Methods

This was a randomized, parallel-controlled clinical trial, with two arms (experimental and control group), and it was conducted over the course of a year in the Oncology Hospitalization Unit at the CAUSA. Participants were assessed at three points during the study. First assessment was prior to hospital discharge, second assessment was after 15 days, and final assessment was at one-month post-hospital follow-up. The main variables to be studied are the dependency levels (Barthel), cancer-related fatigue (FACT-An), health-related quality of life (EuroQoL-5D), functional capacity (SPPB) and kinesiophobia (TSK-F).

Results

Sample size (n = 44). Mean age 63.46 ± 12.36 years. Significant differences between control and experimental group participants in Barthel, FACT-An, TSK-F and SPPB scores (p = 0.000) at follow-up and final assessment.

Conclusions

There are beneficial effects of a multimodal physical exercise and functional rehabilitation program in improving the autonomy of cancer-related fatigue patients.
Trials registration: The clinical trial was registered in ClinicalTrials.gov (NCT04761289). (18/02/2021). https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000AP1U&selectaction=Edit&uid=U0004OJ7&ts=2&cx=bz92lb
A Clinical Trial on Anti-diabetic Efficacy of Submerged Culture Medium of Ceriporia lacerata Mycelium
Authors: Kim Bo-Hyung , Yim Sung-Vin , Hwang Seong Deok , Kim Yoon Soo , Kim Jeong-Hwan 
Published: October 2022

Abstract
Background
Increased glucose level and insulin resistance are major factors in Type 2 diabetes mellitus (T2M), which is chronic and debilitating disease worldwide. Submerged culture medium of Ceriporia lacerata mycelium (CLM) is known to have glucose lowering effects and improving insulin resistance in a mouse model in our previous studies. The main purpose of this clinical trial was to evaluate the functional efficacy and safety of CLM in subjects with impaired fasting blood sugar or mild T2D for 6-12 weeks.
Methods
A total of 72 subjects with glucose intolerance or mild T2D were participated in a randomized, double-blind, placebo-controlled clinical trial. All subjects were randomly assigned into the CLM group or placebo group. Fasting blood glucose (FBG), HbA1c, insulin, C-peptide, HOMA-IR, and HOMA-IR by C-peptide were used to assess the anti-diabetic efficacy of CLM for 6-12 weeks.
Results
In this study, the effectiveness of CLM on lowering all the anti-diabetic indicators (C-peptide levels, insulin, and FBG) was confirmed. CLM significantly elicited anti-diabetic effects after 6-12 weeks of ingestionwithout showing any side effects in both groups of subjects. After the CLM treatment, FBG levels were effectively dropped by 63.9% (ITT), while HOMA-IR level of in the CLM group with FBG >110 mg/dL showed a marked decrease by 34% up to 12 weeks. Remarkably, the effect of improving insulin resistance was significantly increased in the subgroup of subjects with insulin resistance, exhibiting effective reduction at 6 weeks (42.5%) and 12 weeks (61%), without observing a recurrence or hypoglycemia. HbA1c levels were also decreased by 50% in the subjects with reduced indicators. Additionally, it is noteworthy that the levels of insulin and C-peptide were significantly reduced despite the CLM group with FBG >110 mg/dL. No significant differences were detected in the other parameters (lipids, blood, serum, and blood pressure) after 12 weeks.
Conclusion
The submerged culture medium of CLM showed clinical efficacy in the improvement of FBG, insulin, C-peptide, HbAc1, and HOMA-index. Thiswork could guide the new treatment pathway of diabetes in a non-invasive manner using a microbiome-based anti-diabetic ingredient to surge global diabetic epidemic.
The risk of cervical lesions caused by HPV16/18 combined with other high-risk and low-risk HPV types: A retrospective study
Authors: Wang Yan-Ling , Li Shu , Zhu Jing-fen , Wang Xiao-yun , Ma Ming-jun , Xiao Rui-ying , Li Li-dan , Wu Su-fang , Zhu Ya-ping , Yang Yong-bin 
Published: October 2022

AbstractBackground HPV16 and 18 are the most common high-risk human papillomavirus (HPV) types causing cervical lesions. Women with HPV16 and/or 18(HPV16/18) infections are the main targets for cervical screening. But the HPV16/18 infection status is complex, and clarifying the risk of different infection patterns for cervical lesions is essential for subsequent management options. Our study aimed to assess the risk of HPV16 or 18 combined with other high-risk(HR) and/or low-risk(LR) HPV types for cervical lesions and their clinical characteristics. Methods In this retrospective study, we analyzed the clinical data of 3,217 patients with HPV16/18 infection.We divided HPV16 or HPV18 multiple infections into 8 patterns: HPV16 + HR, HPV16 + LR, HPV16 + HR + LR, HPV18 + HR, HPV18 + LR, HPV18 + HR + LR, HPV16 + 18 and HPV16 + 18 + other-HPV. The analysis of data was performed by Chi-square test and multinational logistic regression.P < 0.05 was considered statistically significant. Results Among the HPV16/18 positive population, multiple infections accounted for 41.5% (1336/3217), and multiple infections were mainly associated with LSIL while single infection was more associated with HSIL+. And the risk of cervical lesions varied with different infection patterns. After adjusting co-factors, multiple logistic regression showed that compared with single HPV16 or 18 infection, HPV16 + HR and HPV18 + HR had a higher risk for LSIL(OR = 1.659, 95%=1.278–2.153; OR = 1.744,95%=1.046–2.907) while HPV16 + LR had a lower risk for HSIL+(OR = 0.477, 95%CI = 0.277–0.822). Conclusion Single HPV16 or 18 infection is more relevant to HSIL + with respect to multiple infections. Multiple infections may be transient that mainly lead to LSIL. Different infection patterns of multiple infections have different risks for cervical lesions, HPV16 or 18 combined with other HR-HPV are associated with a higher risk of LSIL, but HPV16 combined with LR-HPV decreases the risk of HSIL+. We propose that there is antagonistic relationship between HPV16 and some LR-HPV types.
Significant influence of North Pacific Ocean variability on summer rainfall in the Central Europe
Authors: Hari Vittal , Zhang Wei , Rakovec Oldrich , Koppa Akash , Gao Si , Yang Wenchang , Vecchi Gabriel , Kumar Rohini 
Published: October 2022

Abstract
Since the beginning of the 21st century, Central Europe (CE) has experienced a series of dry summers with substantial socioeconomic and environmental impacts1-7. Large-scale atmospheric mechanisms and teleconnection patterns leading to such events are still ambiguous8. Here, using observations and controlled climate model experiments, we demonstrate the prominent role of the far-reaching Pacific Meridional Mode (PMM)9,10 on the CE summer rainfall (CESR) inter-annual variability. A strong positive phase of PMM leads to a significant rainfall deficit over CE (10--15%; p-value < 0.05) during the boreal summer and vice-versa. We demonstrate the implications of this novel teleconnection pattern in improving the prediction of CESR -- along with the mutually exclusive and independent North Atlantic Oscillation (NAO) climatic mode, which is one of several well-established large-scale atmospheric drivers affecting the European climate11. Our study thus reveals the far-reaching influences of the North Pacific Ocean on improved prediction of the CESR variability, whose value to adaption and mitigation strategies can hardly be overemphasized.
High purity silicon whiskers extraction from silica by novel simple technology
Authors: Kudyakova Valeriya S. , Vagizova Elizaveta M. , Shishkin Roman A. 
Published: October 2022

Abstract
Si dendrites and whiskers were obtained by interaction of gaseous AlF with SiO2 during transport chemical reaction, using Al, AlF3 and SiO2 as starting materials. The dependence of the reaction yield on such technological parameters as temperature, transport gas flow-rate, reactor chamber pressure and molar ratio of the initial compounds was determined. The thermodynamic simulation of processes in reaction chamber was performed by the HSC Chemistry program using HSC-Reaction and HSC-Gibbs modules. Reaction products were characterized by X-ray powder diffraction and scanning electron microscopy. Obtained Si crystallizes as dendrites and whiskers with diameters varying in 100 nm – 24 µm range. The obtained data shows perspectives for adaptation of the proposed technology for production of Si anode material; moreover, the mechanism of proposed synthesis method can be improved for one-stage production of Si/C composite by using CO2 in process as C source as well as development of a novel CO2 utilization technology.
Membrane mediated mechanical stimuli produces distinct active states in the AT1 receptor
Authors: Poudel Bharat , T. Rajitha Rajeswhar , Vanegas Juan 
Published: October 2022

Abstract
The Angiotensin II Type 1 (AT1) receptor is one of the most widely studied GPCRs within the context of biased signaling. While the AT1 receptor is activated by agonists such as the peptide AngII, it can also be activated by mechanical stimuli such as membrane stretch or shear in the absence of a ligand. Despite the importance of mechanical activation of the AT1 receptor in biological processes such as vasoconstriction, little is known about the structural changes induced by external physical stimuli mediated by the surrounding lipid membrane. Here, we present a systematic simulation study that characterizes the activation of the AT1 receptor under various membrane environments and mechanical stimuli. We show that stability of the active state is highly sensitive to membrane thickness and tension. Structural comparison of membrane-mediated vs.~agonist-induced activation shows that the AT1 receptor has distinct active conformations. This is supported by multi-microsecond free energy calculations that show unique landscapes for the inactive and various active states. Our modeling results provide structural insights into the mechanical activation of the AT1 receptor and how it may produce different functional outcomes within the framework of biased agonism.