bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of SGLT2 inhibitors with cardiovascular, kidney, and safety outcomes among patients with diabetic kidney disease: a meta-analysis
Authors: Kaze Arnaud D. , Zhuo Min , Kim Seoyoung C. , Patorno Elisabetta , Paik Julie M. 
Published: March 2022

Abstract
Background
We conducted a systematic review and meta-analysis of the cardiovascular, kidney, and safety outcomes of sodium-glucose cotransporter 2 inhibitors (SGLT2i) among patients with diabetic kidney disease (DKD).

Methods
We searched electronic databases for major randomized placebo-controlled clinical trials published up to September 30, 2021 and reporting on cardiovascular and kidney outcomes of SGLT2i in patients with DKD. DKD was defined as chronic kidney disease in individuals with type 2 diabetes. Random-effects meta-analysis models were used to estimate pooled hazard ratios (HR) and 95% confidence intervals (CI) for clinical outcomes including major adverse cardiovascular events (MACE: myocardial infarction [MI], stroke, and cardiovascular death), kidney composite outcomes (a combination of worsening kidney function, end-stage kidney disease, or death from renal or cardiovascular causes), hospitalizations for heart failure (HHF), deaths and safety events (mycotic infections, diabetic ketoacidosis [DKA], volume depletion, amputations, fractures, urinary tract infections [UTI], acute kidney injury [AKI], and hyperkalemia).

Results
A total of 26,106 participants with DKD from 8 large-scale trials were included (median age: 65.2 years, 29.7–41.8% women, 53.2–93.2% White, median follow-up: 2.5 years). SGLT2i were associated with reduced risks of MACE (HR 0.83, 95% CI 0.75–0.93), kidney composite outcomes (HR 0.66, 95% CI 0.58–0.75), HHF (HR 0.62, 95% CI 0.55–0.71), cardiovascular death (HR 0.84, 95% CI 0.74–0.96), MI (HR 0.78, 95% CI 0.67–0.92), stroke (HR 0.76, 95% CI 0.59–0.97), and all-cause death (HR 0.86, 95% CI 0.77–0.96), with no significant heterogeneity detected. Similar results were observed among participants with reduced estimated glomerular filtration rate (eGFR: < 60 mL/min/1.73m2). The relative risks (95% CI) for adverse events were 3.89 (1.42–10.62) and 2.50 (1.32–4.72) for mycotic infections in men and women respectively, 3.54 (0.82–15.39) for DKA, and 1.29 (1.13–1.48) for volume depletion.

Conclusions
Among adults with DKD, SGLT2i were associated with reduced risks of MACE, kidney outcomes, HHF, and death. With a few exceptions of more clear safety signals, we found overall limited data on the associations between SGLT2i and safety outcomes. More research is needed on the safety profile of SGLT2i in this population.
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial
Authors: Niemiro Grace M , Coletta Adriana M , Agha Nadia H. , Mylabathula Preteesh Leo , Baker Forrest L. , Brewster Abenaa M , Bevers Therese B , Fuentes-Mattei Enrique , Basen-Engquist Karen , Katsanis Emmanuel , Gilchrist Susan C , Simpson Richard J. 
Published: March 2022

Abstract
Background
Immunosenescence is described as age-associated changes within the immune system that are responsible for decreased immunity and increased cancer risk. Physically active individuals have fewer ‘senescent’ and more naïve T-cells compared to their sedentary counterparts, but it is not known if exercise training can rejuvenate ‘older looking’ T-cell profiles. We determined the effects of 12-weeks supervised exercise training on the frequency of T-cell subtypes in peripheral blood and their relationships with circulating levels of the muscle-derived cytokines (i.e. ‘myokines’) IL-6, IL-7, IL-15 and osteonectin in older women at high risk of breast cancer. The intervention involved 3 sessions/week of either high intensity interval exercise (HIIT) or moderate intensity continuous exercise (MICT) and were compared to an untrained control (UC) group.

Results
HIIT decreased total granulocytes, CD4+ T-cells, CD4+ naïve T-cells, CD4+ recent thymic emigrants (RTE) and the CD4:CD8 ratio after training, whereas MICT increased total lymphocytes and CD8 effector memory (EM) T-cells. The change in total T-cells, CD4+ naïve T-cells, CD4+ central memory (CM) T-cells and CD4+ RTE was elevated after MICT compared to HIIT. Changes in $$ \dot{\mathrm{V}}{\mathrm{O}}_{2\max } $$

V
̇

O

2
max

after training, regardless of exercise prescription, was inversely related to the change in highly differentiated CD8+ EMRA T-cells and positively related to changes in β2-adrenergic receptor (β2-AR) expression on CM CD4+ and CM CD8+ T-cells. Plasma myokine levels did not change significantly among the groups after training, but individual changes in IL-7 were positively related to changes in the number of β2-AR expressing CD4 naïve T cells in both exercise groups but not controls. Further, CD4 T-cells and CD4 naive T-cells were negatively related to changes in IL-6 and osteonectin after HIIT but not MICT, whereas CD8 EMRA T-cells were inversely related to changes in IL-15 after MICT but not HIIT.

Conclusions
Aerobic exercise training alters the frequency of peripheral T-cells associated with immunosenescence in middle aged/older women at high risk of breast cancer, with HIIT (pro-senescent) and MICT (anti-senescent) evoking divergent effects. Identifying the underlying mechanisms and establishing whether exercise-induced changes in peripheral T-cell numbers can alter the risk of developing breast cancer warrants investigation.
Cancer survivors post-chemotherapy exhibit unique proprioceptive deficits in proximal limbs
Authors: Wang Allison B. , Housley Stephen N. , Flores Ann Marie , Cope Timothy C. , Perreault Eric J. 
Published: March 2022

Abstract
Background
Oxaliplatin (OX) chemotherapy for colorectal cancer is associated with adverse neurotoxic effects that can contribute to long-term sensorimotor impairments in cancer survivors. It is often thought that the sensorimotor impairments are dominated by OX-induced dying-back sensory neuropathy that primarily affects the distal regions of the limb. Recent preclinical studies have identified encoding dysfunction of muscle proprioceptors as an alternative mechanism. Unlike the dying-back sensory neuropathy affecting distal limbs, dysfunction of muscle proprioceptors could have more widespread effects. Most investigations of chemotherapy-induced sensorimotor impairments have considered only the effects of distal changes in sensory processing; none have evaluated proximal changes or their influence on function. Our study fills this gap by evaluating the functional use of proprioception in the shoulder and elbow joints of cancer survivors post OX chemotherapy. We implemented three multidirectional sensorimotor tasks: force matching, target reaching, and postural stability tasks to evaluate various aspects of proprioception and their use. Force and kinematic data of the sensorimotor tasks were collected in 13 cancer survivors treated with OX and 13 age-matched healthy controls.

Results
Cancer survivors exhibited less accuracy and precision than an age-matched control group when they had to rely only on proprioceptive information to match force, even for forces that required only torques about the shoulder. There were also small differences in the ability to maintain arm posture but no significant differences in reaching. The force deficits in cancer survivors were significantly correlated with self-reported motor dysfunction.

Conclusions
These results suggest that cancer survivors post OX chemotherapy exhibit proximal proprioceptive deficits, and that the deficits in producing accurate and precise forces are larger than those for producing unloaded movements. Current clinical assessments of chemotherapy-related sensorimotor dysfunction are largely limited to distal symptoms. Our study suggests that we also need to consider changes in proximal function. Force matching tasks similar to those used here could provide a clinically meaningful approach to quantifying OX-related movement dysfunction during and after chemotherapy.
Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects
Authors: Landsiedel Robert , Hahn Daniela , Ossig Rainer , Ritz Sabrina , Sauer Lydia , Buesen Roland , Rehm Sascha , Wohlleben Wendel , Groeters Sibylle , Strauss Volker , Sperber Saskia , Wami Haleluya , Dobrindt Ulrich , Prior Karola , Harmsen Dag , van Ravenzwaay Bennard , Schnekenburger Juergen 
Published: March 2022

Abstract
Background
The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but also intestinal microbes. The gut microbiota contributes essentially to human health, whereas gut microbial dysbiosis is known to promote several intestinal and extra-intestinal diseases. Gut microbiota-derived metabolites, which are found in the blood stream, serve as key molecular mediators of host metabolism and immunity.

Results
Gut microbiota and the plasma metabolome were analyzed in male Wistar rats receiving either SiO2 (1000 mg/kg body weight/day) or Ag nanoparticles (100 mg/kg body weight/day) during a 28-day oral gavage study. Comprehensive clinical, histopathological and hematological examinations showed no signs of nanoparticle-induced toxicity. In contrast, the gut microbiota was affected by both nanoparticles, with significant alterations at all analyzed taxonomical levels. Treatments with each of the nanoparticles led to an increased abundance of Prevotellaceae, a family with gut species known to be correlated with intestinal inflammation. Only in Ag nanoparticle-exposed animals, Akkermansia, a genus known for its protective impact on the intestinal barrier was depleted to hardly detectable levels. In SiO2 nanoparticles-treated animals, several genera were significantly reduced, including probiotics such as Enterococcus. From the analysis of 231 plasma metabolites, we found 18 metabolites to be significantly altered in Ag-or SiO2 nanoparticles-treated rats. For most of these metabolites, an association with gut microbiota has been reported previously. Strikingly, both nanoparticle-treatments led to a significant reduction of gut microbiota-derived indole-3-acetic acid in plasma. This ligand of the arylhydrocarbon receptor is critical for regulating immunity, stem cell maintenance, cellular differentiation and xenobiotic-metabolizing enzymes.

Conclusions
The combined profiling of intestinal microbiome and plasma metabolome may serve as an early and sensitive indicator of gut microbiome changes induced by orally administered nanoparticles; this will help to recognize potential adverse effects of these changes to the host.
The prevalence of thoracic aorta aneurysm as an important cardiovascular disease in the general population
Authors: Mehrabi Nasab Entezar , Athari Seyyed Shamsadin 
Published: March 2022

AbstractBackgroundThe aorta is the largest and main artery in the body. The enlargement of the aortic diameter known as ectasia results in aneurysm. Thoracic aorta aneurysm can involve one or more segments of the aorta. Non-invasive imaging techniques play an important role in identifying patients, estimating maximal aneurysm diameter, following up patients, and detecting complications. So, this study was performed to estimate the prevalence of ascending thoracic aorta aneurysm in the general population of Iran.MethodsPeople with an abnormal aortic size (˃ 36 mm) were enrolled and subjected to diagnostic tests, and related risk factors were assessed.ResultOf the 3400 people examined, 410 (12%) had abnormal aorta sizes, and 42 (1.2%) had ascending aorta aneurysm. Out of the 410 patients with elevated aorta size, 235 (57%) were males, and 175 (43%) were females. Overall, 229 patients (56%) had hypertension, and 255 (62%) were over 60 years old.ConclusionIn this study, we showed that the prevalence of ascending aorta aneurysm in the general population of Iran was about 1.2%. Ascending aorta aneurysm is a threatening pathology of the aorta. The high prevalence of hypertension may explain the high incidence of aneurysm in our studied population. Therefore, it is necessary to implement an accurate screening plan to identify patients with hypertension and provide appropriate treatment and adequate follow up to patients. Patients with ascending aorta aneurysm are also recommended to modify their lifestyles.
Lung transplantation with concomitant cardiac repair for congenital hypoplasia of bilateral pulmonary arteries and patent ductus arteriosus
Authors: Cheng Che-Chih , Lin Ming-Tai , Huang Shu-Chien , Hsu Hsao-Hsun 
Published: March 2022

Abstract
Background
Profound pulmonary arterial hypertension with end-stage right heart failure is considered to be the main cause of death in children with un-repaired congenital heart disease, and the traditional surgical treatment is heart–lung transplantation. We performed bilateral lung transplantation (LTx) with concomitant cardiac repair, and the patient has uplifting outcome.

Case presentation
We have reported the case of a patient with congenital hypoplasia of the bilateral pulmonary arteries and patent ductus arteriosus. The patient’s clinical condition was gradually worsening and severely limited his ability to perform the activities of daily life. Bilateral LTx with concomitant patent ductus arteriosus repair was performed at the age of 11 years. The postoperative course was smooth and cardiopulmonary function nearly returned to normal according to radiological and laboratory examinations.

Conclusions
Bilateral LTx with concomitant cardiac repair may be superior to heart–lung transplantation in the case of the specific congenital heart disease.
Identifying Outcomes of Patients With Advanced Pancreatic Adenocarcinoma and RECIST Stable Disease Using Radiomics Analysis
Authors: Yang Qiuxia , Mao Yize , Xie Hui , Qin Tao , Mai Zhijun , Cai Qian , Wen Hailin , Li Yong , Zhang Rong , Liu Lizhi 
Published: March 2022

PURPOSE Few studies have explored the biomarkers for predicting the heterogeneous outcomes of patients with advanced pancreatic adenocarcinoma showing stable disease (SD) on the initial postchemotherapy computed tomography. We aimed to devise a radiomics signature (RS) to predict these outcomes for further risk stratification. MATERIALS AND METHODS Patients with advanced pancreatic adenocarcinoma and SD after chemotherapy were included. Pancreatic lesions on initial postchemotherapy computed tomography images were evaluated by radiomics analysis for predicting early death (≤ 1 year). RS was then internally and externally tested. The progression-free survival and objective response rate were compared between the low-risk and high-risk group of patients classified following RS. RESULTS Approximately 62.7% of patients receiving chemotherapy showed SD at first response evaluation in the primary cohort, which were 59.6% and 57.9% in internal and external testing cohorts, respectively. The RS predicted 1-year overall survival well, with areas under the receiver operating characteristic curve of 0.91 in the training cohort, 0.90 in the validation cohort, 0.84 in the internal testing cohort, and 0.87 in the external testing cohort. The high-risk group had a shorter median progression-free survival (7.3 months v 9.0 months, P = .016, in the training cohort; 5.9 months v 9.2 months, P = .026, in the internal testing cohort) and a lower objective response rate (2.2% v 24.0% in the training cohort) than the low-risk group. In addition, RS was not related to the clinical characteristics and chemotherapy regimens. CONCLUSION RS independently predicts the outcomes of patients with SD after chemotherapy well and can help to improve treatment decisions by identifying patients for whom current treatment may not be suitable.
Hydrothermal synthesis of CeO2 nanoparticles and its application in electrochemical detection of nitrofurantoin antibiotics
Authors: Rudayni Hassan Ahmad , Chaudhary Anis Ahmad , Abu-Taweel Gasem Mohammad , Shariq Mohammad , Imran Mohd 
Published: March 2022

Abstract
In recent years, antibiotics have been considered emerging pollutants due to their continuous input and their persistence in the aquatic ecosystem, even at low concentrations. The present work focuses on the successful hydrothermal synthesis and characterization of CeO2 nanoparticles for the electrochemical detection of nitrofurantoin (NFT) antibiotic. Their physicochemical properties were studied by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and UV-Vis spectroscopy. The average particle size and the energy bandgap of CeO2 nanoparticles were found to be 9.59 nm and 3.3 eV, respectively. Furthermore, electrochemical analysis showed that the developed CeO2 -based electrode showed improved electrocatalytic activity towards the oxidation of nitrofurantoin (NFT) compared to the bare electrode. The limit of detection (LOD) was obtained as 7.81 μM from the calibration curve. Hence, these results corroborate that the CeO2 nanoparticles modified electrode can serve as a novel NFT electrocatalyst.
FMRP protects the lung from xenobiotic stress by facilitating the integrated stress response
Authors: Sain Basu Deblina , Bhavsar Rital , Gulami Imtiyaz , Chavda Saraswati , Lingamallu Sai Manoz , Muddashetty Ravi , Veeranna Chandrakanth , Chattarji Sumantra , Thimmulappa Rajesh , Bhattacharya Aditi , Guha Arjun 
Published: March 2022

ABSTRACT
Stress response pathways protect the lung from the damaging effects of environmental toxicants. Here we investigate the role of the fragile X mental retardation protein (FMRP), a multifunctional protein implicated in stress responses, in the lung. We report that FMRP is expressed in murine and human lungs, in the airways and more broadly. Analysis of airway stress responses in mice and in a murine cell line ex vivo, using the well-established naphthalene injury model, reveals that FMRP-deficient cells exhibit increased expression of markers of oxidative and genotoxic stress and increased cell death. Further inquiry shows that FMRP-deficient cells fail to actuate the integrated stress response pathway (ISR) and upregulate the transcription factor ATF4. Knockdown of ATF4 expression phenocopies the loss of FMRP. We extend our analysis of the role of FMRP to human bronchial BEAS-2B cells, using a 9,10-phenanthrenequinone air pollutant model, to find that FMRP-deficient BEAS-2B cells also fail to actuate the ISR and exhibit greater susceptibility. Taken together, our data suggest that FMRP has a conserved role in protecting the airways by facilitating the ISR.
This article has an associated First Person interview with the first author of the paper.
Genome-wide Association Study of Liking for Several Types of Physical Activity in the UK Biobank and Two Replication Cohorts
Authors: KLIMENTIDIS YANN C. , NEWELL MICHELLE , VAN DER ZEE MATTHIJS D. , BLAND VICTORIA L. , MAY-WILSON SEBASTIAN , ARANI GAYATRI , MENNI CRISTINA , MANGINO MASSIMO , ARORA AMIT , RAICHLEN DAVID A. , ALEXANDER GENE E. , WILSON JAMES F. , BOOMSMA DORRET I. , HOTTENGA JOUKE-JAN , DE GEUS ECO J. C. , PIRASTU NICOLA 
Published: March 2022

ABSTRACT

Introduction
A lack of physical activity (PA) is one of the most pressing health issues today. Our individual propensity for PA is influenced by genetic factors. Stated liking of different PA types may help capture additional and informative dimensions of PA behavior genetics.

Methods
In over 157,000 individuals from the UK Biobank, we performed genome-wide association studies of five items assessing the liking of different PA types, plus an additional derived trait of overall PA-liking. We attempted to replicate significant associations in the Netherlands Twin Register (NTR) and TwinsUK. Additionally, polygenic scores (PGS) were trained in the UK Biobank for each PA-liking item and for self-reported PA behavior, and tested for association with PA in the NTR.

Results
We identified a total of 19 unique significant loci across all five PA-liking items and the overall PA-liking trait, and these showed strong directional consistency in the replication cohorts. Four of these loci were previously identified for PA behavior, including CADM2, which was associated with three PA-liking items. The PA-liking items were genetically correlated with self-reported (r
g = 0.38–0.80) and accelerometer (r
g = 0.26–0.49) PA measures, and with a wide range of health-related traits. Each PA-liking PGS significantly predicted the same PA-liking item in NTR. The PGS of liking for going to the gym predicted PA behavior in the NTR (r
2 = 0.40%) nearly as well as a PGS based on self-reported PA behavior (r
2 = 0.42%). Combining the two PGS into a single model increased the r
2 to 0.59%, suggesting that PA-liking captures distinct and relevant dimensions of PA behavior.

Conclusions
We have identified the first loci associated with PA-liking and extended our understanding of the genetic basis of PA behavior.
Στρατηγικές αντιμετώπισης αντίξοων καταστάσεων, αντιλαμβανόμενο αίσθημα απειλής και πηγές κοινωνικής υποστήριξης σε ενηλίκους κατά την περίοδο της πανδημίας COVID-19
Authors: Αντωνίου Αλέξανδρος Σταμάτιος , Greenglass Esther , Δημόπουλος Μελέτιος Αθανάσιος , Χρούσος Γεώργιος , Παπαγεωργίου Χαράλαμπος , Τούντας Γιάννης 
Published: March 2022

Σκοπός της παρούσας έρευνας είναι η διερεύνηση των στρατηγικών αντιμετώπισης αντίξοων καταστάσεων, της αντιλαμβανόμενης απειλής και των παραγόντων κοινωνικής υποστήριξης σε ενηλίκους κατά την περίοδο της πανδημίας COVID-19 και συνιστά την ελληνική συμμετοχή στο πλαίσιο ευρύτερης διεθνούς μελέτης που διεξάγεται σε πολλές Ευρωπαϊκές χώρες, ΗΠΑ, Καναδά, Κίνα, Ισραήλ και άλλες. Το δείγμα της ελληνικής έρευνας περιελάμβανε 2.137 ενηλίκους (1.617 άνδρες και 518 γυναίκες). Οι συμμετέχοντες συμπλήρωσαν ερωτηματολόγια μέσω διαδικτύου σχετικά με θέματα ψυχοσωματικής υγείας και συμπεριφοράς. Στο παρόν άρθρο παρουσιάζονται τα αποτελέσματα που αφορούν στις στρατηγικές αντιμετώπισης στρεσογόνων καταστάσεων όπως αυτές έχουν αποτυπωθεί μέσω της ομώνυμης κλίμακας του Carver (1997) και των κλιμάκων: κοινωνικής υποστήριξης (Caplan et al., 1980), συμπεριφορών αποφυγής/δράσης (Greenglass, 2019), και αίσθησης απειλής από τον κορωνοϊό (Marjanovic et al., 2013). Τα ευρήματα έδειξαν ότι ένα σημαντικό ποσοστό του δείγματος ανέφερε ότι κατά την ψυχοπιεστική αυτή περίοδο κατέφευγε σε τεχνικές που αποσκοπούν στη ρύθμιση του συναισθήματος και στην επίλυση του προβλήματος. Επιπλέον, στις στρατηγικές αντιμετώπισης, βρέθηκαν στατιστικώς σημαντικές διαφορές μεταξύ των δύο φύλων, με τους άνδρες να αναφέρουν συστηματικότερη χρήση τους. Τα άτομα ηλικίας 18-27 ετών παρουσίασαν χαμηλότερες τιμές στην ενεργητική αντιμετώπιση, συγκριτικά με όλες τις υπόλοιπες ηλικιακές ομάδες. Επίσης, βρέθηκε ότι όσοι δεν είχαν ολοκληρώσει την τριτοβάθμια εκπαίδευση ανέφεραν ότι έκαναν πιο συχνή χρήση των τεχνικών άρνησης της υφιστάμενης κατάστασης. Στατιστικά σημαντικοί προβλεπτικοί παράγοντες του αισθήματος απειλής ήταν η ρύθμιση του συναισθήματος και οι συμπεριφορές αποφυγής. Τα ευρήματα συζητούνται με βάση τα σύγχρονα μοντέλα στρατηγικών αντιμετώπισης αντίξοων καταστάσεων.