bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical risk assessment in Hiv-infected patients treated within the penitentiary system of Kemerovo region
Authors: Malashenko A. A. , Krasnov K. A. , Krasnov O. A. 
Published: January 2022

Aim. To assess the surgical risk in HIV-infected patients who received the surgical treatment within the penitentiary system of Kemerovo Region.Materials and Methods. We retrospectively analysed the physical status and the extent of surgical risk in 296 HIV-infected patients who underwent elective (n = 201) or emergency (n = 95) surgery in Hospital №1 (Kemerovo) from 2015 to 2018. Physical status was assessed according to American Society of Anesthesiologists (ASA) Physical Status Classification System. Surgical risk was scored according to Moscow Scientific Society of Anesthesiologists and Critical Care.Results. The majority of patients had 3 (48.4 and 36.3% in emergency and elective patients, respectively) or 4a (30.5 and 45.8% in emergency and elective patients, respectively) stages of HIV infection. Opportunistic infections were diagnosed in 49.3% of patients and were always accompanied by superficial mycoses. Physical status of most patients (47.4% and 63.7% in emergency and elective patients, respectively) corresponded to ASA physical status class 3. Emergency patients mainly had surgical risk class 3 (n = 50, 52.6%) while elective patients often had surgical risk class 2 (n = 106, 52.7%). The prevalence of postoperative complications, most often impaired wound healing, was 9.8%.Conclusion. More than 80% of HIV-infected patients who underwent surgical interventions within the penitentiary system of Kuzbass were at III or IV stages of HIV infection, entailing a high frequency of opportunistic diseases such as superficial mycoses and dictating the need to include antifungal treatment into the surgical treatment. Impaired wound healing was the most frequent postoperative complication.
Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit
Authors: Osyaev N. Yu. , Ivannikova N. V. , Vavin G. V. , Moses V. G. , Gruzdeva O. V. , Kutikhin A. G. 
Published: January 2022

Aim. Severe COVID-19 is accompanied by reduced blood oxygen saturation, systemic inflammatory response syndrome and multiple organ failure, all causing a significant deterioration of homeostasis associated with death. Here we aimed to study the risk factors for death in patients with severe COVID-19 who have been admitted to an intensive care unit.Materials and Methods. The study included 144 consecutive patients with severe COVID-19 who have been admitted to an intensive care unit of Kuzbass Clinical Hospital from August to December 2020. Groups of survivors and non-survivors were equal in number (n = 72) and matched by gender (36 men and women) and age (median age 64 years, interquartile range 56-70 years in survivors and 58-69 years in non-survivors). Complete blood count, urinalysis, biochemical analysis, coagulation testing, and measurement of anti-SARS-CoV-2 IgM/IgG were carried out in all patients immediately upon the admission to intensive care unit.Results. Risk factors for death in severe COVID-19 at the admission to intensive care unit were arterial hypertension, chronic heart failure, peripheral atherosclerosis, impaired renal homeostasis (reduced glomerular filtration rate, elevated serum creatinine and urea, proteinuria, hematuria), augmented fasting blood glucose and lactate, neutrophilia (in men), lymphopenia and increased neutrophil-to-lymphocyte ratio (in women), and decreased IgM/IgG to SARS-CoV-2 (in women).Conclusion. We found both independent and gender-specific risk factors for death due to COVID-19.
Galectin-1 and Galectin-3 expression in colon cancer and its correlation with tumor invasion, differentiation, and metastatic spread
Authors: Kolobovnikova Yu. V. , Urazova O. I. , Poletika V. S. , Reyngardt G. V. , Romanova E. V. , Kurnosenko A. V. , Dmitrieva A. I. , Yankovich K. I. , Grishchenko M. Yu. 
Published: January 2022

Aim. To study the expression of galectin-1 and galectin-3 in colon cancer and the levels of these proteins in the peripheral blood in relation to the differentiation, invasion, and metastatic dissemination.Materials and Methods. We examined primary tumors and the corresponding peripheral blood samples from 81 patients with colon cancer. Control group consisted of 49 patients with colon adenoma and 17 healthy volunteers. Expression of galectin-1 and galectin-3 in colon tissue was determined by immunohistochemical staining, while their plasma level was measured by enzyme-linked immunosorbent assay. Tumor staging was performed in accordance with the TNM system (AJCC, 2009). Cell differentiation was defined according to the respective clinical guidelines (Russian Cancer Association, 2018).Results. We detected an elevated expression of galectin-1 and galectin-3 in primary colon cancer as compared with colon adenoma and higher plasma levels of these proteins in colon cancer patients in comparison with healthy volunteers. High expression of tumor and plasma galectin-1 was associated with higher tumor stage (T3/T4) and the presence of local and distant metastases. Overexpression of galectin-3 in the primary tumor correlated with lower differentiation and lymph node metastasis.Conclusion. Galectin-1 and galectin-3 are involved in colon cancer progression and might be used as predictors of an adverse outcome.
Prototyping neural networks to evaluate the risk of adverse cardiovascular outcomes in the population
Authors: Bogdanov L. A. , Komossky E. A. , Voronkova V. V. , Tolstosheev D. E. , Martsenyuk G. V. , Agienko A. S. , Indukaeva E. V. , Kutikhin A. G. , Tsygankova D. P. 
Published: January 2022

Aim. To develop a neural network basis for the design of artificial intelligence software to predict adverse cardiovascular outcomes in the population.Materials and Methods. Neural networks were designed using the database of 1,525 participants of PURE (Prospective Urban Rural Epidemiology Study), an international, multi-center, prospective study investigating disease risk factors in the urban and rural areas. As this study is still ongoing, we analysed only baseline data, therefore switching prognosis and diagnosis task. Because of its leading prevalence among other cardiovascular diseases, arterial hypertension was selected as an adverse outcome. Neural networks were designed employing STATISTICA Automated Neural Networks (SANN) software, manually selected, cross-validated, and transferred to the original graphical user interface software.Results. Input risk factors were gender, age, place of residence, concomitant diseases (i.e., coronary artery disease, chronic heart failure, diabetes mellitus, chronic obstructive pulmonary disease, and asthma), active or passive smoking, regular use of medications, family history of arterial hypertension, coronary artery disease or stroke, heart rate, body mass index, fasting blood glucose and cholesterol, high- and low-density lipoprotein cholesterol, and serum creatinine levels. Our neural networks showed a moderate efficacy in the virtual diagnostics of arterial hypertension (84.5%, or 1,289 successfully predicted outcomes out of 1,525, area under the ROC curve = 0.88), with almost equal sensitivity (83.6%) and specificity (85.3%), and were successfully integrated into graphical user interface that is necessary for the development of the commercial prognostication software. Cross-validation of this neural network on bootstrapped samples of virtual patients demonstrated sensitivity of 82.7 – 84.7%, specificity of 84.5 – 87.3%, and area under the ROC curve of 0.88 – 0.89.Conclusion. The artificial intelligence prognostication software to predict adverse cardiovascular outcomes in the population can be developed by a combination of automated neural network generation and analysis followed by manual selection, cross-validation, and integration into graphical user interface.
Insulin gene expression and functional activity of insulin signaling pathway in Alzheimer's disease
Authors: Gorina Y. V. , Khilazheva E. D. , Komleva Yu. K. , Lopatina O. L. , Salmina A. B. 
Published: January 2022

Aim. To study the insulin (INS) gene expression, insulin and lactate levels, expression of Fe65 adapter protein, and level of oxidative DNA damage marker γH2AX in different brain areas in the experimental model of Alzheimer's disease.Materials and Methods. Male, 4-month-old C57BL/6 mice received either intrahippocampal injection of β-amyloid (C57BL/6 + Aβ 1-42) or phosphate-buffered saline (C57BL/6 + PBS). Insulin (INS) gene expression in the hippocampus and amygdala was assessed by means of reverse transcription-polymerase chain reaction. Levels of lactate and insulin in different brain areas were measured by enzyme-linked immunosorbent assay. Expression of Fe65 adapter protein and γH2AX in the hippocampus was studied by immunofluorescence staining followed by confocal microscopy.Results. We found an overexpression of the INS gene in the hippocampus and amygdala, an increase in lactate level in the hippocampus, and slightly increased insulin level in the amygdala of mice with Alzheimer's disease as compared with the control group. Neurodegeneration was accompanied by an elevated endothelial expression of Fe65 adapter protein (p= 0.04) and γH2AX in hippocampal neurons (p = 0.04).Conclusion. Alzheimer's disease neurodegeneration is accompanied by a disrupted insulin signaling and impaired glucose metabolism in the hippocampus and amygdala. This further leads to a neuronal accumulation of γH2AX and impaired amyloid precursor protein proteolysis because of insulin inability to inhibit its interaction with the Fe65 adapter protein and to prevent formation and deposition of β-amyloid.
The impact of legionellosis into fatal outcomes of pneumonia in Irkutsk
Authors: Botvinkin A. D. , Svistunov V. V. , Sidorova E. A. , Makarova A. E. , Kravchenko N. A. , Stepanenko L. A. , Bayanova T. A. , Lemeshevskaya M. V. , Balandina T. P. , Gibteva O. S. , Andaev E. I. , Balakhonov S. V. 
Published: January 2022

Aim. To study the diagnosis of legionellosis in patients who died because of pneumonia in Irkutsk (2016-2018).Materials and Methods. We performed 65 autopsies of patients who died from pneumonia in Irkutsk (2016-2018), studied their case histories, and interrogated 510 tap water samples for Legionella pneumophila by means of inoculation and polymerase chain reaction.Results. Among 65 fatal pneumonia outcomes registered in Irkutsk during 2016-2018, legionellosis has been confirmed in three cases (4.6%). Two of these patients were at the late stages of HIV infection while the third, 74-yearold, patient had multiple comorbid conditions. Nosocomial infection was suspected in one of these cases. None of these three patients left Irkutsk during the last month of their life. The assumed transmission factor was tap water, as Legionella pneumophila was found in tap water samples collected in 2013 and 2015.Conclusion. Patients with severe pneumonia need screening for legionellosis to perform the correct treatment, particularly during COVID-19 pandemic.
Incidence of multiple sclerosis and prevalence of its risk factors in Russian Federation
Authors: Svetlichnaya A. V. , Vyazovichenko Yu. E. , Torchinskiy N. I. , Korshunov V. A. 
Published: January 2022

Aim. To study the incidence and prevalence of multiple sclerosis risk factors in Russian Federation from 2009 to 2019.Materials and Methods. We used official records of Ministry of Health of Russian Federation and conducted a survey of 50 patients with multiple sclerosis (16 men and 34 women) admitted to the Sechenov University Clinic of Neurological Disorders to determine subjective risk factors.Results. Current incidence of multiple sclerosis in Russian Federation is 3.8 per 100,000 population, with a steady increase from 2009 to 2019. The highest and the lowest incidence values were registered in the Central Federal District (4.5 per 100,000 population) and Far Eastern Federal District (2.0 per 100,000 population). The most common subjective risk factors were female gender, past medical history of viral diseases, chronic bacterial infections, and emotional stress.Conclusion. Incidence of multiple sclerosis in Russian Federation is currently rising that highlights the need in the improved therapeutic protocols.
Impact of comorbidities on older patients undergoing open heart surgery
Authors: Mikus Elisa , Calvi Simone , Albertini Alberto , Tripodi Alberto , Zucchetta Fabio , Brega Carlotta , Pin Maurizio , Cimaglia Paolo , Ferrari Roberto , Campo Gianluca , Serenelli Matteo 
Published: January 2022

Background
The number of elderly patients undergoing cardiac surgery is increasing. Age greater than 80 years has been identified as a strong independent risk factor for shortand long-term survival. The current study is aimed to identify the impact of preoperative comorbidities on early and late outcomes in older patients undergoing cardiac surgery.

Methods
Baseline characteristics, procedurals and postoperative complications of all patients undergoing cardiac surgery at our institution are collected. The current analysis is focused on patients aged at least 80 years at the time of intervention and treated from January 2010 to December 2019.

Results
In-hospital mortality resulted as 6.3%. Redo intervention [odds ratio (OR) 2.49, 95% confidence interval (CI) 1.13–5.48], chronic obstructive pulmonary disease (COPD) (OR 2.99, 95% CI 1.75–5.12) and peripheral arterial disease (PAD) (OR 2.23, 95% CI 1.30–3.81) were independent baseline predictors of outcome in the multivariate analysis. Prolonged extracorporeal circulation time, need for transfusion and prolonged intubation time strongly and independently predicted in-hospital mortality. During a mean follow-up of 3.6 years 34.3% of patients died and unplanned admission (HR 1.33, 95% CI 1.05–1.67), NYHA class III-IV (HR 1.35, 95% CI 1.12–1.64), diabetes (HR 1.27, 95% CI 1.01–1.59), COPD (HR 1.60, 95% CI 1.25–2.04) and PAD (HR 1.32, 95% CI 1.03–1.71) resulted as independent predictors of all-cause death.

Conclusion
Cardiac surgery is feasible in octogenarians, with an acceptable risk of mortality. Chronological age itself should not be the main determinant of choice while referring patients for cardiac surgical intervention. Comorbidities such as COPD, PAD and diabetes need to be taken into account for risk stratification.
Geodiversity and geoheritage in the perspective of geography
Authors: Claudino-Sales Vanda 
Published: January 2022

Abstract
The paper states that geodiversity is the abiotic complement to biodiversity, and is considered to be the elements associated with the abiotic environment, e.g. geological diversity, geomorphodiversity, pedodiversity, hydrodiversity and climodiversity. Geoheritage is considered as the geological heritage of a site, but is here presented as the abiotic heritage of a site, and is related to geological heritage, geomorphoheritage, pedoheritage, hydroheritage and climoheritage. Thus, it is possible to talk about geological sites, geomorphosites, pedosites, hydrosites and climosites. Geodiversity and geoheritage are strongly linked to geology. However, it is also a new paradigm to geography, as physical geography classically works with abiotic and biotic environments.
Taking care of a real self - description of the psychotherapeutic process of a patient with narcissistic personality disorders in the field of dance/movement psychotherapy
Authors: Drzał Ewelina 
Published: January 2022

Abstract

Introduction: Dance/movement psychotherapy (DMT) is a psychotherapeutic trend that belongs to the approaches that involve working with the body. Thinking about a wider perspective, DMT belongs to the group of action-oriented psychotherapies. It assumes that the person, while moving, can show his/her emotional states. Additionally, it can lead to development and personal integration. The goal is to deepen awareness. Psychotherapy with dance and movement is practiced among psychotic patients, patients suffering from neurotic or personality disorders, and as a method of personal development. The aim of the work is to describe the psychotherapeutic process of an individual client in the field of dance/movement psychotherapy as a method in which dance leads to development and personal integration.

Material and method: Working with a client, Beata, took place in a strictly defined setting. Meetings took place once a week in the same office during 55 minutes. They were of an individual nature. First, Beata was diagnosed according to the DSM-5 [1] and ICD-10 [2] classification, which was supplemented with the PDM-2 diagnosis [3]. During the therapeutic work, the phenomena of transference and countertransference were taken into account, the patient’s behavior was interpreted according to John Bowlby’s attachment theory and mentalization. During practicing DMT it is important to take care of Authentic Movement method, observation of movement using the Laban Bartenieff Movement System (LBMS) method and the Kastenberg Movement Profile (KMP).

Results: The changes that DMT psychotherapy started to bring were observed both in the client’s movement and in the verbal layer. The client has acquired the ability to observe her feelings and needs. This influenced her perception of announcement heard from different people and the decisions she made. The DMT therapy with Beata is not over yet, which makes it possible to take a deeper look at topics related to therapeutic goals.

Conclusions: Dance/movement psychotherapy has proved to be an effective method of working with patients with personality disorders psychopathology of the narcissistic type. This method makes it possible to build a sense of the patient’s boundaries and needs, and to strengthen self-esteem. Sessions seem to be very helpful in integrating inner life, feelings and experience. In addition, it helps in dealing with the internal tension of patients and gives the opportunity to expand ranges of movement. In the verbal part, it is possible to discuss the problems that the client carries within himself, which cause him fear, anxiety and other unpleasant emotions.
The Relationship Between Jurisdiction and the Local Authority’s Online Sustainability Disclosure
Authors: Joseph Corina , Michael Heidi Christy Mingi 
Published: January 2022

The objective of this paper is to examine the relationship between jurisdiction and the extent of sustainability information disclosure on Malaysian local authority websites. The extent of online sustainability disclosure is examined utilizing the coercive isomorphism tenet in both quantitative and qualitative phases. In the quantitative stage, the analysis of 139 websites was conducted. The General Linear Model is utilized to determine the relationship between jurisdiction (measured by different states) and the extent of online sustainability information disclosure. In the qualitative phase, the semi-structured interviews were carried out to answer the underlying possible reasons derived from the quantitative phase. The quantitative phase provided evidence that various states have applied distinctive degree of coercive pressures on the extent of sustainability information disclosure on Malaysian local authority websites. The interview findings revealed additional factors that are relating to the jurisdiction: political, state leadership, and bureaucratic procedure implemented by different states. The paper has recognized the impact of coercive isomorphism for the jurisdiction utilizing both quantitative and qualitative phases.
Antecedent of Online Buying Behavior
Authors: Faisal Aekram 
Published: January 2022

This research was conducted to determine the effect of availability, low price, promotion, comparison, convenience, customer service, perceived ease of use, attitude, time consciousness, trust, and variety seeking on online buying behavior. This study aims to examine what factors influence online buying behavior. The methodology of this research is to test the research hypothesis. Sampling with a questionnaire of 250 respondents who are consumers who have shopped online in the past year. Non-probability sampling technique using purposive sampling method. The analysis tool is structural equation model (SEM). The results of this study indicate that low price, convenience, perceived ease of use, attitude, time consciousness, trust, and variety seeking service are factors that can directly influence online buying behavior. Whereas availability, promotion, comparison, and customer service are not factors that can directly influence online buying behavior. This study has limitations, including this research only carried out on customers from online stores found on the online shopping website in jabodetabek, besides that this research is only limited to variables that directly affect online buying behavior without seeing any mediating factors. The implication of this research is that managers can increase the factors that can influence purchasing behavior online, and this research can also be a reference for marketers to implement appropriate strategies to increase their sales.Keywords: online buying behavior.
Determinant Factors Affecting Fraud Detection Capabilities to The External Auditor in Jakarta
Authors: Yuniati Triana , Banjarnahor Erliana 
Published: January 2022

The perspective of this study provides empirical evidence on the factors that affect the auditor's fraud detection ability. There are effective research hypotheses with auditor tenure, fraud detection experience, level of education, fraud training, prof professional skepticism. This study is hypothesis-testing research, Respondents are 120 auditors from seven public accounting firms in Jakarta participated in this study, thought a questionnaire. Data collected is done during April 201 5 by visiting the public accounting firm that has been willing to participate in this study. The type of data used is primary data and is a cross-section, data is collected only once. Conclusion of the study is auditor tenure, fraud training does not affect the ability to detect fraud. While fraud detection experience, the auditor's level of education and professional skepticism positively influence fraud detection capability. Limitations, suggestions and research implications are described at the end of this report.
Duque Cornejo en Colombia: el San Joaquín de Popayán y sus copias
Authors: García Luque Manuel 
Published: January 2022

El artículo plantea la atribución al escultor sevillano Pedro Duque Cornejo (1678-1757) de una escultura de San Joaquín conservada en la iglesia del Carmen de Popayán (Colombia). Para ello, se reconstruye el contexto creativo de la obra, se plantean algunas hipótesis sobre sus potenciales comitentes y se evalúa su repercusión en el medio local, donde fue copiada hasta en tres ocasiones. Su caso resulta significativo para el estudio del comercio de escultura entre España y América durante el siglo XVIII y prueba que el taller de Duque Cornejo tuvo una proyección americana desconocida hasta la fecha.