bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Medical versus Surgical Management of Incomplete Abortion in Uganda. an Open Labeled Randomized Clinical Trial
Authors: Otieno Victor Tetty , Byonanuwe Simon , Bonet Ivan , Emillio Sanchez , Atuheire Collins 
Published: March 2022

Abstract
Background: Management decision on whether to use medical or surgical method in women diagnosed with incomplete abortion particularly in the first trimester has been a controversial topic in Uganda and the world in general with no local studies comparing effectiveness and secondary outcomes between the two approaches. This has posed a big challenge to the attending clinicians as regards making informed management options when encountered with such cases.Methods: A five months prospective open labeled randomized clinical trial involving 100 consecutively recruited participants was conducted from June 1st, 2018 to October 30th, 2018. Ethical clearance was obtained from KIUREC and UNCST. Data collection was achieved using an investigator administered questionnaire; in-depth face to face interviews as well as laboratory and ultrasound scan report forms. Baseline demographic and clinical characteristics were assessed using univariate analysis. Statistical difference was considered when p<0.05. Numerical variables were summarized using means, medians for non-normally distributed variables, and frequencies or proportions for categorical variables. All statistical analysis was carried out using IBM SPSS Statistics software version 23.0. Results: The effectiveness of surgical management was higher than that of medical management (RRR=11.7%; p=0.043). Majority in the medical arm reported mild pain (64% vs 4%; p<0.001) while most of those in surgical arm reported severe pain (78% vs 8%; p<0.001). Bleeding was prolonged in the medical arm method with majority of those in surgical arm reporting bleeding for less than six hours (94% vs 46%; p=0.0002). Although medical method had longer bleeding, it was associated with lesser symptoms of headache, dizziness, syncope and blood transfusion. 90% of those in medical arm and only 50% of those in surgical method would recommend the method assigned (p<0.001). Fever, chills and nausea were more common in medical method. Average hospital stay was longer in medical method (p=0.03). Only one participant in surgical arm developed infection while no patient had genitourinary trauma. There was no statistical significant difference between the satisfaction levels in the two arms. Conclusion: Surgical management is more effective than medical management. Although medical management has prolonged expulsion bleeding, prolonged hospital stay and increased fevers, chills and nausea that are self-limiting; it has reduced pain. Most patients are satisfied with and would recommend medical management.
New ITS rDNA barcodes clarify phylogenetic relationships and biogeography of aquatic hyphomycetes
Authors: Duarte Ricardo , Fernandes Isabel , Gulis Vladislav , Cássio Fernanda , Pascoal Cláudia 
Published: March 2022

Abstract
Aquatic hyphomycetes are key microbial decomposers of allochthonous organic matter in freshwater ecosystems. Although their importance in carbon flow and food webs in streams is widely recognized, there are still gaps in our understanding of their phylogeny, molecular diversity and distribution patterns. Our study utilized the growing database of ITS rDNA barcodes of aquatic hyphomycetes (1252 sequences) and aimed to (i) produce new barcodes for some lesser-known taxa of aquatic hyphomycetes, (ii) clarify the phylogeny of aquatic hyphomycetes, including the placement of some taxa at the class or order level based on molecular data, and (iii) provide insights into biogeography of this group. This study increased the number of aquatic hyphomycetes with available ITS barcode from 120 species (out of ~ 300 species described) to 136 species. Phylogenetically, the 136 species of aquatic hyphomycetes were distributed between two phyla (Ascomycota and Basidiomycota), 6 classes and 10 orders of fungi. However, 36 species remain incertae sedis without attribution at the order level. The geographical distribution of species with available ITS sequences included 50 countries from 5 continents. North American and European countries showed the highest number of aquatic hyphomycete species with ITS barcodes, with 6 countries having more than 20 species: Portugal (34 species), United States of America (33 species), United Kingdom (29 species), Germany (28 species), France (22 species) and Czech Republic (21 species).
Heat-induced maternal effects shapes avian eggshell traits and embryo development and phenotype in high incubation temperatures
Authors: Hoffman Alexander , Dees Leslie , Wada Haruka 
Published: March 2022

Abstract
Populations without a sufficient rate of genetic adaptation may risk extinction in the face of rapid environmental change, however, phenotypic plasticity can facilitate their persistence. For example, mothers can prepare offspring for the thermal environment they will experience through maternal effects. In oviparous species, little is known about how variation in the timing and intensity of thermal stressors influences embryo phenotype. We demonstrate that when zebra finch mothers are exposed to a mild heat conditioning as juveniles, their embryos do not exhibit the increased water loss and shorter development times at high incubation temperatures shown by embryos from control mothers. Mothers exposed to the mild heat conditioning as juveniles and a high heat stressor as adults produced eggs with a higher density of shell pores, embryos with lower heart rates during development, and hatchlings with heavier pectoralis muscles when incubated at a high temperature. However, maternal heat exposure was only positively correlated with embryo survival at a control temperature, where embryos produced by mothers exposed to only the mild heat conditioning exhibited higher survival rates than all other groups. These results demonstrate that the thermal environment experienced by mothers can influence the physiology of their embryos and eggshell characteristics.
Corneal Densitometry in Bilateral Keratoconus Patients With Unilateral Corneal Vogt’s Striae: a Contralateral Eye Study
Authors: Wei Shengsheng , Li Jing , Li Yong , Zhang Yaohua , Cai Yan , Du Jing , Liu Jianguo , Wang Yan 
Published: March 2022

Abstract
Purpose: To investigate corneal densitometry and correlations with corneal morphological parameters in bilateral keratoconus (KCN) patients with unilateral Vogt’s striae. Methods: In total, 112 patients (224 eyes) were enrolled in this cross-sectional contralateral eye study. Corneal densitometry and morphological parameters were measured using Pentacam HR. Results: Corneal densitometry values of the anterior 0-2 mm and 2-6 mm, intermediate 0-2 mm and 2-6 mm, posterior 2-6 mm, and total cornea 2-6 mm were significantly higher in eyes with Vogt’s striae than in eyes without Vogt’s striae (P<0.05), while those of the anterior 6-10 mm, posterior 0-2 mm, and total cornea 6-10 mm were significantly lower in the former (P<0.05). Corneal densitometry values in the anterior 0-2 mm and total cornea 2-6 mm were positively correlated with K1, K2, Km, Kmax, anterior corneal elevation, and posterior corneal elevation (P<0.05) and negatively correlated with central corneal thickness and thinnest corneal thickness in eyes with Vogt’s striae (P<0.05). K2, Km, and Kmax were significantly correlated with densitometry values of the anterior 0-2 mm and intermediate 0-2 mm in eyes without Vogt’s striae (P<0.05). Densitometry values of the anterior and intermediate layers in the central cornea were higher in eyes with Vogt’s striae, while those of the anterior corneal stroma in the central region of the cornea were higher than those of the peripheral cornea in all eyes. Conclusions: Vogt’s striae mainly occur on the anterior and intermediate layers during the progression of KCN.
The Roles of Customer Perception of Innovativeness and Engagement on Loyalty through Value Co-creation Behaviors: The Case of Food-delivery Service
Authors: Paringan Adinda Toti , Novani Santi 
Published: March 2022

The food delivery service that has gained popularity over the last few years should preserve its competitiveness by developing customer satisfaction and loyalty through customer value co-creation behaviors. However, there is still limited literature on understanding the antecedents and implications of customer value co-creation behavior in the service industry. The research aimed to evaluate the effect of customer perceptions of innovativeness and customer engagement on value co-creation behavior. Also, this study wants to reveal the relationship between value co-creation behavior on customer satisfaction and loyalty in food delivery services, using Service-Dominant (S-D) logic perspective. A survey of Indonesian GoFood customers was conducted through an online questionnaire. Then, 349 complete responses were empirically analyzed using the Partial Least Squares-Structural Equation Modeling (PLS-SEM) method. The findings reveal that customer engagement and perceived innovativeness affect customer value co-creation behavior. However, customer participation does not immediately increase customer loyalty. Instead, it must be accompanied by an increase in customer satisfaction. By investigating the antecedents and implications of value co-creation behavior among food delivery service users, the research provides practitioners with viable business strategies for maximizing customer loyalty by evaluating service innovation and the customers' behavior in co-creation value. Moreover, the research contributes to the theoretical development of customer value co-creation behaviors and the foodservice business.
Ayurvedic hospital wastewater degradation using electrochemical treatment
Authors: Mahesh S. , Shivaprasad K. S. , Sanjana Mahesh 
Published: March 2022

Abstract
The goal of this research was to remove COD, oil and grease (O&G) and color from raw ayurvedic hospital wastewater (AHWW) using a novel electrochemical coagulation (ECC) process. Cell voltage was initially optimized using iron electrodes in bipolar mode for both raw AHWW and ayurvedic hospital therapy room wastewater (AH-TRWW) for a pre-optimized electrolysis time (ET) of 60 min. O&G, COD and color removals for AHWW at 8 V optimized cell voltage were 96, 61 and 96% respectively. Different electrode materials, copper, aluminum, graphite, were used to evaluate relative performances at 8 V. Iron electrodes showed maximum pollutant removal from raw AHWW. The sludge obtained after the ECC process showed good settling and filterability properties compared to graphite and aluminum electrodes. The low SVI value of 146 mL/g was obtained exercising absolute control on sludge volume. Solids flux values showed assurances of compact settling tank design with least spatial footprint. EDX analysis for ECC sludge of AHWW using iron showed gross elements 40.19% C, 48.63% O and 7.92% Fe redefining the fate of sludge. The XRD pattern of the ECC sludge showed an amorphous nature. Post-ECC filtration effluent showed clear water reclamation of 80–82%, proving the effectiveness of the novel ECC treatment process.
Wedelolactone, a Component from Eclipta prostrata (L.) L., Inhibits the Proliferation and Migration of Head and Neck Squamous Cancer Cells through the AhR Pathway
Authors: Liu Yanqiu , Zou Yi-xuan , Mu Zhen-qiang , Wang Jie , Tian Shuo , Li Yilin 
Published: March 2022

Background:Ecliptae prostrata (L.) L. has been widely used in East Asia with reported biological activities, including anti-cancer properties.Objective:We aimed to investigate the effect of ethyl acetate extract of Ecliptae prostrata (L.) L. (EAE) and its component wedelolactone on the proliferation and migration of head and neck squamous cancer cells.Methods:The proliferation of human SCC-4 and mouse CU110-1 tongue squamous carcinoma cells was assessed using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) method. Scratch wound assays were performed to assess cell migration rates. The levels of Ecadherin and vimentin were used as markers of the epithelial-to-mesenchymal transition (EMT). AhR, CYP1A1, and CYP1B1 levels were examined to uncover the mechanism of inhibition of cell migration by wedelolactone.Results:We found that EAE and wedelolactone decreased the proliferation of human SCC-4 cells and mouse CU110-1 cells at doses of EAE at > 25 μg/ml and wedelolactone at > 6.25 μg/ml. Similarly, both EAE and wedelolactone produced inhibitory effects against migration, but the effective doses that significantly inhibited migration were lower than those affecting proliferation. Wedelolactone below 12.5 μg/ml inhibited the epithelial-to-mesenchymal transition (EMT) with increased expression of E-cadherin and decreased expression of vimentin in SCC-4 and CU110-1 cells. Further analysis showed wedelolactone inhibited the expression of AhR and its downstream target molecules CYP1A1 and CYP1B1 in both squamous carcinoma cells at the same doses inhibiting cell migration. The addition of benzo (a)pyrene [B(a)P], an agonist of AhR, stimulated migration, especially in the CU110-1 cells with reported cancer stem cell-like characteristics. Instructively, B(a)P reversed the inhibitory effects of wedelolactone on AhR expression and cell migration, suggesting that wedelolactone antagonizes cell migration through the AhR pathway. Moreover, the higher activity of EAE and wedelolactone against the migration of cancer stem-like CU110-1 cells relative to SCC-4 cells suggests selective activity against cancer stem cells.Conclusion:Our study identifies wedelolactone as a major active component of Ecliptae prostrata (L.) L. with promising anti-cancer properties against head and neck squamous cancer cells.
Key Advances in MIP-based Sensors Applied for Cancer and Cardiovascular
Biomarkers Detection
Authors: Lamaoui Abderrahman , Amine Aziz 
Published: March 2022

Abstract:
Cancer and cardiovascular diseases have become one of the leading causes of death worldwide. Therefore, early detection of these diseases and rapid intervention by medical staff remain a great challenge for clinicians and healthcare providers worldwide. Cancer and cardiovascular disease biomarkers are promising tools for early diagnosis of the disease before it becomes incurable at an advanced stage. They also contribute to monitoring the progress of therapy and surgical treatment. Indeed, sensors have shown great importance for the detection of cancer and cardiovascular biomarkers. Sensors usually require a recognition element for the selective detection of targets. Molecularly imprinted polymer (MIP), as an artificial antibody, has been proposed as an alternative recognition element in sensing fields to overcome the main drawbacks of natural antibodies. With the high need for sensors providing results in a short time and making easier the early diagnosis of these diseases, MIP-based sensors are attracting considerable interest recently, which will undoubtedly be increased in the future due to the sustainability trend. The key aim of this review is to emphasize the recent applications of sensors based on MIP for the detection of cancer and cardiovascular biomarkers and to highlight the key advances related to MIP-based sensors. Furthermore, several key future trends about the applications of MIP-based sensors for the detection of cardiovascular and cancer biomarkers are presented.
Targeting Janus Kinase (JAK) for Fighting Diseases: The Research of
JAK Inhibitor Drugs
Authors: Zhao Min-Yan , Zhang Wen , Rao Guo-Wu 
Published: March 2022

Abstract:
Janus Kinase (JAK), a nonreceptor protein tyrosine kinase, has emerged as an
excellent target through research and development since its discovery in the 1990s. As
novel small-molecule targeted drugs, JAK inhibitor drugs have been successfully used in
the treatment of rheumatoid arthritis (RA), myelofibrosis (MF), and ulcerative colitis
(UC). With the gradual development of JAK targets in the market, JAK inhibitors have
also received considerable feedback in the treatment of autoimmune diseases, such as
atopic dermatitis (AD), Crohn's disease (CD), and graft-versus-host disease (GVHD).
This article reviews the research progress of JAK inhibitor drugs, focusing on the existing
JAK inhibitors in the market and some JAK inhibitors in clinical trials currently. In addition,
the synthesis of various types of JAK inhibitors and the effects of different drug
structures on drug inhibition and selectivity are summarized.
Screening of Phytoconstituents from Traditional Plants against SARSCoV-
2 using Molecular Docking Approach
Authors: Saini Deepika , Madan Kumud , Chauhan Shilpi 
Published: March 2022

Background:
The emergence of COVID-19 as a fatal viral disease encourages researchers to
develop effective and efficient therapeutic agents. The intervention of in silico studies has led to revolutionary
changes in the conventional method of testing the bioactivity of plant constituents.

Objective:
The current study deals with the investigation of some traditional immunomodulators of plant
origin to combat this ailment.

Materials and Methods:
A total of 151 phytomolecules of 12 immunomodulatory plants were evaluated
for their inhibitory action against the main protease (PDB ID: 7D1M) and NSP15 endoribonuclease (PDB
ID: 6WLC) by structure-based virtual screening. In addition, the promising molecules with ligand efficiency
of more than -0.3(kcal/mol)/heavy atoms were further predicted for pharmacokinetic properties
and druggability using the SwissADME web server, and their toxicity was also evaluated using Protox-II.

Result:
Myricetin-3-O-arabinofuranoside of cranberry plant was found to be the most potential candidate
against both enzymes: main protease (–14.2 kcal/mol) and NSP15 endoribonuclease (–12.2 kcal/mol).

Conclusion:
The promising outcomes of the current study may be implemented in future drug development
against coronavirus. The findings also help in the development of lead candidates of plant origin
with a better ADMET profile in the future.
Evaluation and Prediction of End of Second-wave and Starting of Thirdwave
Covid-19 Cases in India
Authors: Veer Karan , Sharma Sachin 
Published: March 2022

Background:
The second wave of coronavirus has appeared to be an extensive uphill of the number of daily new confirmed cases, recovered cases, and deaths than the first wave in India and the whole world. In India, the second wave of COVID-19 is much dangerous than the first wave that hit on 14th April 2020. The maximum number of new cases was 406901 recorded on May 7, 5.3 times more than the first wave peak. Many researchers worldwide are using machine learning prediction models to forecast the upcoming trends of this pandemic.

Method:
This study used an Autoregressive Integrated Moving Average (ARIMA) model to pre-dict the daily new confirmed cases, daily new deaths, and daily new recoveries between and after the second wave of COVID-19 in India. The dataset was collected from March 14, 2020- July 7, 2021, using the ARIMA model to predict corona cases for the next 60 days.

Results:
In the context of the current scenario in India, the second wave will score low new cases in mid-August 2021, and the third wave will hit the country in the middle of September 2021.

Conclusion:
The ARIMA model was chosen based on AIC (Akaike Information Criterion) values and acquired the maximum accuracy of 95%.
A Case of Chronic HCV Infection Reactivation in a Psoriasis Patient
Treated with Guselkumab
Authors: Ruggiero Angelo , Megna Matteo , Fabbrocini Gabriella , Gallo Lucia , Patrì Angela 
Published: March 2022

Introduction:
Psoriasis is a chronic inflammatory skin disease requiring long-term
treatment. However, there are approximately 71 million individuals with chronic HCV infection
worldwide. In psoriatic patients affected by chronic HCV infection, conventional systemic drugs
may be frequently contraindicated, while data on biologics use are limited.

Case presentation:
The case of a 48-year-old Caucasian man suffering from a severe form of
plaque psoriasis and affected by a chronic-HCV-infection treated with guselkumab has been reported.
Despite a huge improvement of the skin lesions (PASI reduced from 18 to 2), guselkumab
was discontinued due to an HCV-infection reactivation after 3 months of treatment.

Conclusion:
To the best of our knowledge, this is the first case report of the use of guselkumab in
an HCV psoriatic patient. Further studies are needed to evaluate the safety of guselkumab in chronic
HCV patients.
Analytical Transient Thermal Model for Predicting Cooldown
Temperature in a Subsea Pipe-in-Pipe Flowline System
Authors: Shukla Keshawa 
Published: March 2022

Background:
For the reliable operation of deep-water production systems transporting
hydrocarbons, the critical flow assurance problems to manage are wax and hydrate
formation and their deposition due to the heat transfer between the production system and
surroundings. Wax and hydrate deposition can restrict the flow with significant production
loss.

Method:
The adequate thermal insulation of such systems can allow the retention of thermal
energy in the production system to ensure that the fluid cooldown temperature remains
above the wax and hydrate formation temperatures. This may provide sufficient time for
taking the preventive measures during an emergency shut-in operation. The purpose of this
paper is to predict the cooldown temperature of a subsea Pipe-in-Pipe flowline system
transporting crude oil from the reservoir to the host facility using a recently developed transient
thermal model. The model incorporates the energy redistribution inside the system
through the internal temperature gradient and allows to determine the requirement of thermal
insulation of the Pipe-in-Pipe system to retain sufficient heat before the fluid temperature
falls below the hydrate and wax temperatures.

Result:
The model results are compared with an industry accepted commercial simulator
results to illustrate the accuracy of the model for emergency shut-in operations.

Conclusion:
With limited pipeline configurations and fluid properties, the model can successfully
predict the requirements of thermal insulation and cooldown temperature efficiently
and economically.
Development and Validation of Stability Indicating RP-HPLC Method for
Simultaneous Determination of Doxycycline and Rifampicin in Polymeric
Nanoparticles
Authors: Dawre Shilpa 
Published: March 2022

Background:
The combination of doxycycline (DOXY) and rifampicin (RIF) is recom-mended as a treatment therapy for brucellosis by the World Health Organization.

Objective:
The aim of the current study was to develop and validate the stability-indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for the analysis of a combina-tion of doxycycline & rifampicin.

Methods:
The RP-HPLC method was developed and validated to estimate the doxycycline and ri-fampicin combination as per ICH guidelines. The drug combination solution was exposed to differ-ent stress conditions: acidic, basic, photo-oxidation, and oxidation.

Results:
The method was found linear in the range of 2 -10μg/mL for both the drugs with a reten-tion time of 3.5 min for doxycycline and 6.5 min for rifampicin at lambda maximum of 350 nm. The RP-HPLC method was precise and accurate with %RSD < 2%. The intra-day and inter-day precisions were calculated and found within the acceptable range of 5%. Both drugs demonstrated good stability in the mobile phase after 6 hours. The LOD and LOQ of doxycycline and rifampicin were 100 ng/mL & 200ng/mL and 150ng/mL & 500ng/mL, respectively. The forced degradation of the combination of drug solutions was performed. The degraded drug peaks were well-resolved from the peaks of drugs. The percentage encapsulation efficiency of doxycycline and rifampicin in the nanoparticle system was assessed by utilizing the validated RP-HPLC method and found >60% (DOXY) and >70% (RIF).

Conclusion:
The developed RP-HPLC method of DOXY-RIF combination was rapid, accurate, precise, and stability-indicating. The method can be appropriately applied todetecte drugs in the na-noparticulate system.