bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to gender-affirming hormones during adolescence and mental health outcomes among transgender adults
Authors: Turban Jack L. , King Dana , Kobe Julia , Reisner Sari L. , Keuroghlian Alex S. 
Published: January 2022

Objective
To examine associations between recalled access to gender-affirming hormones (GAH) during adolescence and mental health outcomes among transgender adults in the U.S.

Methods
We conducted a secondary analysis of the 2015 U.S. Transgender Survey, a cross-sectional non-probability sample of 27,715 transgender adults in the U.S. Using multivariable logistic regression adjusting for potential confounders, we examined associations between access to GAH during early adolescence (age 14–15), late adolescence (age 16–17), or adulthood (age ≥18) and adult mental health outcomes, with participants who desired but never accessed GAH as the reference group.

Results
21,598 participants (77.9%) reported ever desiring GAH. Of these, 8,860 (41.0%) never accessed GAH, 119 (0.6%) accessed GAH in early adolescence, 362 (1.7%) accessed GAH in late adolescence, and 12,257 (56.8%) accessed GAH in adulthood. After adjusting for potential confounders, accessing GAH during early adolescence (aOR = 0.4, 95% CI = 0.2–0.6, p < .0001), late adolescence (aOR = 0.5, 95% CI = 0.4–0.7, p < .0001), or adulthood (aOR = 0.8, 95% CI = 0.7–0.8, p < .0001) was associated with lower odds of past-year suicidal ideation when compared to desiring but never accessing GAH. In post hoc analyses, access to GAH during adolescence (ages 14–17) was associated with lower odds of past-year suicidal ideation (aOR = 0.7, 95% CI = 0.6–0.9, p = .0007) when compared to accessing GAH during adulthood.

Conclusion
Access to GAH during adolescence and adulthood is associated with favorable mental health outcomes compared to desiring but not accessing GAH.
Evaluating the effectiveness of care coordination interventions designed and implemented through a participatory action research process: Lessons learned from a quasi-experimental study in public healthcare networks in Latin America
Authors: Vázquez María-Luisa , Miranda-Mendizabal Andrea , Eguiguren Pamela , Mogollón-Pérez Amparo-Susana , Ferreira-de-Medeiros-Mendes Marina , López-Vázquez Julieta , Bertolotto Fernando , Vargas Ingrid ,   for Equity LA II
Published: January 2022

Background
Despite increasing recommendations for health professionals to participate in intervention design and implementation to effect changes in clinical practice, little is known about this strategy’s effectiveness. This study analyses the effectiveness of interventions designed and implemented through participatory action research (PAR) processes in healthcare networks of Brazil, Chile, Colombia, Mexico and Uruguay to improve clinical coordination across care levels, and offers recommendations for future research.

Methods
The study was quasi-experimental. Two comparable networks, one intervention (IN) and one control (CN), were selected in each country. Baseline (2015) and evaluation (2017) surveys of a sample of primary and secondary care doctors (174 doctors/network/year) were conducted using the COORDENA® questionnaire. Most of the interventions chosen were based on joint meetings, promoting cross-level clinical agreement and communication for patient follow-up. Outcome variables were: a) intermediate: interactional and organizational factors; b) distal: experience of cross-level clinical information coordination, of clinical management coordination and general perception of coordination between levels. Poisson regression models were estimated.

Results
A statistically significant increase in some of the interactional factors (intermediate outcomes) -knowing each other personally and mutual trust- was observed in Brazil and Chile INs; and in some organizational factors -institutional support- in Colombia and Mexico. Compared to CNs in 2017, INs of Brazil, Chile, Colombia and Mexico showed significant differences in some factors. In distal outcomes, care consistency items improved in Brazil, Colombia and Uruguay INs; and patient follow-up improved in Chile and Mexico. General perception of clinical coordination increased in Brazil, Colombia and Mexico INs. Compared to CNs in 2017, only Brazil showed significant differences.

Conclusions
Although more research is needed, results show that PAR-based interventions improved some outcomes regarding clinical coordination at network level, with differences between countries. However, a PAR process is, by definition, slow and gradual, and longer implementation periods are needed to achieve greater penetration and quantifiable changes. The participatory and flexible nature of interventions developed through PAR processes poses methodological challenges (such as defining outcomes or allocating individuals to different groups in advance), and requires a comprehensive mixed-methods approach that simultaneously evaluates effectiveness and the implementation process to better understand its outcomes.
COVID-19 is associated with higher risk of venous thrombosis, but not arterial thrombosis, compared with influenza: Insights from a large US cohort
Authors: Ward Andrew , Sarraju Ashish , Lee Donghyun , Bhasin Kanchan , Gad Sanchit , Beetel Rob , Chang Stella , Bonafede Mac , Rodriguez Fatima , Dash Rajesh 
Published: January 2022

Introduction
Infection with SARS-CoV-2 is typically compared with influenza to contextualize its health risks. SARS-CoV-2 has been linked with coagulation disturbances including arterial thrombosis, leading to considerable interest in antithrombotic therapy for Coronavirus Disease 2019 (COVID-19). However, the independent thromboembolic risk of SARS-CoV-2 infection compared with influenza remains incompletely understood. We evaluated the adjusted risks of thromboembolic events after a diagnosis of COVID-19 compared with influenza in a large retrospective cohort.

Methods
We used a US-based electronic health record (EHR) dataset linked with insurance claims to identify adults diagnosed with COVID-19 between April 1, 2020 and October 31, 2020. We identified influenza patients diagnosed between October 1, 2018 and April 31, 2019. Primary outcomes [venous composite of pulmonary embolism (PE) and acute deep vein thrombosis (DVT); arterial composite of ischemic stroke and myocardial infarction (MI)] and secondary outcomes were assessed 90 days post-diagnosis. Propensity scores (PS) were calculated using demographic, clinical, and medication variables. PS-adjusted hazard ratios (HRs) were calculated using Cox proportional hazards regression.

Results
There were 417,975 COVID-19 patients (median age 57y, 61% women), and 345,934 influenza patients (median age 47y, 66% women). Compared with influenza, patients with COVID-19 had higher venous thromboembolic risk (HR 1.53, 95% CI 1.38–1.70), but not arterial thromboembolic risk (HR 1.02, 95% CI 0.95–1.10). Secondary analyses demonstrated similar risk for ischemic stroke (HR 1.11, 95% CI 0.98–1.25) and MI (HR 0.93, 95% CI 0.85–1.03) and higher risk for DVT (HR 1.36, 95% CI 1.19–1.56) and PE (HR 1.82, 95% CI 1.57–2.10) in patients with COVID-19.

Conclusion
In a large retrospective US cohort, COVID-19 was independently associated with higher 90-day risk for venous thrombosis, but not arterial thrombosis, as compared with influenza. These findings may inform crucial knowledge gaps regarding the specific thromboembolic risks of COVID-19.
Features of patients who developed hepatocellular carcinoma after direct-acting antiviral treatment for hepatitis C Virus
Authors: Mawatari Seiichi , Kumagai Kotaro , Oda Kohei , Tabu Kazuaki , Ijuin Sho , Fujisaki Kunio , Tashima Shuzo , Inada Yukiko , Uto Hirofumi , Saisyoji Akiko , Hiramine Yasunari , Hashiguchi Masafumi , Tamai Tsutomu , Hori Takeshi , Taniyama Ohki , Toyodome Ai , Sakae Haruka , Kure Takeshi , Sakurai Kazuhiro , Moriuchi Akihiro , Kanmura Shuji , Ido Akio 
Published: January 2022

BackgroundThe features of hepatitis C virus patients with a sustained virologic response (SVR) who developed hepatocellular carcinoma (HCC) after direct-acting antiviral (DAA) therapy are unclear.MethodsThe study population included 1494 DAA-SVR patients without a history of HCC. The cumulative carcinogenesis rate after the end of treatment (EOT) and factors related to HCC were analyzed.ResultsSixty (4.0%) patients developed HCC during a median observation period of 47.6 months. At four years, the cumulative carcinogenesis rate was 4.7%. A Cox proportional hazards analysis showed that age ≥73 years (hazard ratio [HR]: 2.148), male sex (HR: 3.060), hyaluronic acid (HA) ≥75 ng/mL (HR: 3.996), alpha-fetoprotein at EOT (EOT-AFP) ≥5.3 ng/mL (HR: 4.773), and albumin at EOT (EOT-Alb) <3.9 g/dL (HR: 2.305) were associated with HCC development. Especially, EOT-AFP ≥5.3 ng/mL was associated with HCC development after 3 years from EOT (HR: 6.237). Among patients who developed HCC, AFP did not increase in patients with EOT-AFP <5.3 ng/mL at the onset of HCC. Of these 5 factors, EOT-AFP ≥5.3 ng/mL was scored as 2 points; the others were scored as 1 point. The 4-year cumulative carcinogenesis rate for patients with total scores of 0–2, 3–4, and 5–6 points were 0.6%, 11.9%, and 27.1%, respectively (p<0.001).ConclusionsEOT-AFP ≥5.3 ng/mL is useful for predicting HCC development after an SVR. However, AFP does not increase in patients with EOT-AFP <5.3 ng/mL at the onset of HCC. The combination of EOT-AFP, age, sex, HA, and EOT-Alb is important for predicting carcinogenesis.
Effect of hemodialysis on short-term outcomes after colon cancer surgery
Authors: Shiraishi Toshio , Tominaga Tetsuro , Nonaka Takashi , Hashimoto Shintaro , Hamada Kiyoaki , Araki Masato , Sumida Yorihisa , Takeshita Hiroaki , Fukuoka Hidetoshi , Wada Hideo , To Kazuo , Yamashita Mariko , Tanaka Kenji , Sawai Terumitsu , Nagayasu Takeshi 
Published: January 2022

Background
Hemodialysis patients who undergo surgery have a high risk of postoperative complications. The aim of this study was to determine whether colon cancer surgery can be safely performed in hemodialysis patients.

Methods
This multicenter retrospective study included 1372 patients who underwent elective curative resection surgery for colon cancer between April 2016 and March 2020.

Results
Of the total patients, 19 (1.4%) underwent hemodialysis, of whom 19 (100%) had poor performance status and 18 had comorbidities (94.7%). Minimally invasive surgery was performed in 78.9% of hemodialysis patients. The postoperative complication rate was significantly higher in hemodialysis than non-hemodialysis patients (36.8% vs. 15.5%, p = 0.009). All postoperative complications in the hemodialysis patients were infectious type. Multivariate analysis revealed a significant association of hemodialysis with complications (odds ratio, 2.9362; 95%CI, 1.1384–7.5730; p = 0.026).

Conclusion
Despite recent advances in perioperative management and minimally invasive surgery, it is necessary to be aware that short-term complications can still occur, especially infectious complications in hemodialysis patients.
Sign-changing solutions for a Schrödinger–Kirchhoff–Poisson system
with 4-sublinear growth nonlinearity
Authors: Yu Shubin , Zhang Ziheng , Yuan Rong 
Published: January 2022

In this paper we consider the following
Schrödinger–Kirchhoff–Poisson-type system

{

−

(

a
+
b

∫

Ω

|

∇
u

|

2

d
x

)

Δ

u
+
λ

ϕ

u
=
Q
(
x
)

|

u

|

p
−
2

u

in

Ω

,

−

Δ

ϕ

=

u

2

in

Ω

,

u
=

ϕ

=
0

on

∂
Ω

,

where
Ω
is a
bounded smooth domain of

R

3

,
a
>
0
,
b
≥
0
are constants
and
λ
is a positive parameter. Under suitable conditions on
Q
(
x
)

and combining the method of invariant sets of descending flow, we establish
the existence and multiplicity of sign-changing solutions to this problem
for the case that
2
<
p
<
4
as
λ
sufficient small. Furthermore,
for
λ
=
1
and the above assumptions on
Q
(
x
)
, we obtain the same
conclusions with
2
<
p
<

12
5

.
TRAVEL VLOG YOUTUBE: SOCIAL CONSTRUCTION OF TECHNOLOGY AND TRAVELING CULTURE AMONG MILLENNIALS
Authors: Utami Atika Budhi , Suryadi Kencana Ariestyani 
Published: January 2022

Travelling has become a part of lifestyle and has been closely associated with tourism sector which is potential to generate revenue. In the past 20 years, young people have played an important role in the global tourism. Research in Indonesia in 2016 revealed that 35% or 25 million young people out of the country’s 261 million population loved travelling. According to the Indonesia’s Statistic Body (Badan Pusat Statistik), millennials are keen on travelling due to the consumption shift in the society. Our productive generation prefer spending their money on seeking experiences to buying consumptive products. Besides, the fast-changing technology facilitates travellers to document their journey in a vlog format. The vlogs can later be played and shared in the Internet through social media such as YouTube and Instagram. The research aimed to analyze the interpretation of the millennials’ experience after watching travel vlogs in YouTube, and to analyze the meanings of their experience in sharing content in YouTube and other social media platforms. We used Social Construction of Technology (SCoT) Theory with phenomenological approach to analyze the aims. The results showed that travel vlog was a progressive way of the usage and construction of social technology. Travel vlogs have brought a significant increase in travelling culture in millennials. They would rather save money to gain travelling experience than to purchase consumptive goods. They would also prefer sharing their experiences through Instastory feature in Instagram to YouTube. Having said that, YouTube should add a simpler feature so that millennials or travel vloggers can share their travelling experiences in the channel easier.
IMPACTS OF MEDIA LITERACY LEVELS ON HUMAN TRAFFICKING (TPPO) CONTENT
Authors: Andiyansari Popi , Sukmawati Ade Irma 
Published: January 2022

New media is rapidly evolving and has an impact on our daily life. The rapid development of applications and increasing number of social media users can lead the users in a vulnerable condition. Human trafficking, also known as TPPO (Tindak Pidana Perdagangan Orang) in Indonesia, is one of the threats that users encounter, it commonly happens to young users who do not have enough information about it, but they can obtain TPPO information through employment advertisements in the media. The goal of this study is to look at media literacy levels and the correlations between them and TPPO message comprehension in new media. This research used a descriptive quantitative method with a correlation approach, in which associations between variables were measured. The media literacy levels of respondents were measured by using a Likert scale with a range of 1-5. The aspects measured were age, school origin and ownership of social media. These aspects and the TPPO message understanding in new media were measured by a Pearson scale. This study found that the highest level of media literacy was in the age group of 15 years old from SMAN 1(Public Senior High School) Pakem and that the number of social media account ownership did not show a significant relationship with the literacy levels. The measurement on the relationships between the media literacy levels and the TPPO message understanding by using a Pearson scale obtained 0.606; these results indicated that the correlation between both variables was high.
Numerical Modeling of CuInxGa(1-x)Se2/WS2 Thin Solar Cell with an Enhanced PCE
Authors: Belhadji Youcef 
Published: January 2022

Designing thin film solar cells with high and stable output performance under different operating points remains a large area of research. In the context of Chalcopyrite-based solar cells (CuInxGa(1-x)Se2) where the buffer layer is CdS, great progress has been made but research is still underway to optimize their performance. Besides the environmental concerns and limiting factors of CdS material, the use or combination of new materials like ZnS, ZnSe and WS2 as a buffer layer is solicited. Due to these attracted optical and crystallographic properties, Tungsten Disulfide: WS2 is solicited during the last years. Through numerical simulation, we investigate in this work the dc parameters of CuInxGa(1-x)Se2/WS2 solar cell with reduced buffer layer thickness of 30 nm. Considering the presence of neutral and divalent defects in the absorber layer, simulations are performed under the impact of temperature, concentration of charge carriers in WS2 layer and light spectrum change. The divalent defects taken into account are: double donors / acceptors and amphoteric having a Gaussian distribution. For more calculation precision and in order to obtain the desired performance of the solar cell, the impact of series and shunt resistors is also considered. In comparison with results reported in previous works, carried out on the CuInxGa(1-x) Se2/WS2 solar cell, a remarkable improvement in the performance of the solar cell is achieved. When temperature increase by 10K, the short circuit current and open circuit voltage are enhanced by ~0,05mA/cm2 and ~0,0022 respectively. The optimal values of the solar cell parameters obtained in this study are: Jsc≈ 31.0683 (mA/cm2), Voc=1.0173 (V), PCE = 26.72 % and FF=84.54%.
VARIANCE GAMMA PROCESS WITH MONTE CARLO SIMULATION AND CLOSED FORM APPROACH FOR EUROPEAN CALL OPTION PRICE DETERMINATION
Authors: Hoyyi Abdul , Abdurakhman Abdurakhman , Rosadi Dedi 
Published: January 2022

The Option is widely applied in the financial sector. The Black-Scholes-Merton model is often used in calculating option prices on a stock price movement. The model uses geometric Brownian motion which assumes that the data is normally distributed. However, in reality, stock price movements can cause sharp spikes in data, resulting in nonnormal data distribution. So we need a stock price model that is not normally distributed. One of the fastest growing stock price models today is the process exponential model. The process has the ability to model data that has excess kurtosis and a longer tail (heavy tail) compared to the normal distribution. One of the members of the process is the Variance Gamma (VG) process. The VG process has three parameters which each of them, to control volatility, kurtosis and skewness. In this research, the secondary data samples of options and stocks of two companies were used, namely zoom video communications, Inc. (ZM) and Nokia Corporation (NOK). The price of call options is determined by using closed form equations and Monte Carlo simulation. The Simulation was carried out for various values until convergent result was obtained.
On the direction of the velocity and magnetic field fluctuations in undisturbed solar wind
Authors: Erofeev Dmitry V. 
Published: January 2022

Abstract
Measurements of velocity and magnetic field in near-Earth heliosphere is analized in order to investigate systematical deflection from transversality of the velocity and magnetic field fluctuations in undisturbed solar wind. Fluctuations occurred in the meridional plain of heliosphere (RN plain of the RTN reference system) are transversal with respect to mean magnetic field during periods of high solar activity, but they become non-transversal close to solar cycle minima. This phenomenon is investigated focusing on a role of Alfvén waves. It is shown that deflections from transversality is mostly expressed by fluctuations in slow solar wind streams with low contribution of Alfvén waves, whereas strongly Alfvénic turbulence undergo such deflection in a less degree. In addition, we consider orientation of velocity fluctuations in the azimuthal (RT) plain of heliosphere, which also indicates some interesting features.
Assessment of reinforcement learning applications for industrial control based on complexity measures
Authors: Grothoff Julian , Camargo Torres Nicolas , Kleinert Tobias 
Published: January 2022

Abstract
Machine learning and particularly reinforcement learning methods may be applied to control tasks ranging from single control loops to the operation of whole production plants. However, their utilization in industrial contexts lacks understandability and requires suitable levels of operability and maintainability. In order to asses different application scenarios a simple measure for their complexity is proposed and evaluated on four examples in a simulated palette transport system of a cold rolling mill. The measure is based on the size of controller input and output space determined by different granularity levels in a hierarchical process control model. The impact of these decomposition strategies on system characteristics, especially operability and maintainability, are discussed, assuming solvability and a suitable quality of the reinforcement learning solution is provided.
Implementing machine learning: chances and challenges
Authors: Heizmann Michael , Braun Alexander , Glitzner Markus , Günther Matthias , Hasna Günther , Klüver Christina , Krooß Jakob , Marquardt Erik , Overdick Michael , Ulrich Markus 
Published: January 2022

Abstract
Finding and implementing a suitable machine learning (ML) solution to a task at hand has several facets. The technical side of ML has widely been discussed in detail, see, e. g., (Heizmann, M., A. Braun, M. Hüttel, C. Klüver, E. Marquardt, M. Overdick and M. Ulrich. 2020. Artificial Intelligence with Neural Networks in Optical Measurement and Inspection Systems. at – Automatisierungstechnik 68(6): 477–487). This contribution focusses on the industrial implementation issues of ML projects, particularly for machine vision (MV) tasks. Especially in small and medium-sized enterprises (SMEs), resources cannot be activated at will in order to use a new technology like ML. We take this into account by, on the one hand, helping to realistically evaluate the opportunities and challenges involved in implementing ML projects for a given task. On the other hand, we consider not only technical aspects, but also organizational, social and customer-related ones. It is discussed which know-how a company itself has to bring into an ML project and which tasks can also be performed by service providers. Here, it becomes clear that ML techniques can be used at different levels of detail. The question of “make or buy” is therefore also an entrepreneurial one when introducing ML into one’s own products and processes, and must be answered with a view to one’s own possibilities and structures.
Sustainable Management of Environmental Risks in Agricultural Production: Ensuring the Right to Food
Authors: Milian Gómez Jorge Freddy , Delgado Triana Yanelys 
Published: January 2022

Abstract
The current research is about the sustainable management of environmental risks in agricultural production to ensure the right to food. In a globalized world, agricultural production is determined by external economic, environmental, social, legal, and political factors, as well as internal factors depending on each State’s conditions. Environmental risk factors, particularly, the growing climate change and its negative effects or the occurrence of a global pandemic, restrict agricultural industry development and create uncertainty in guaranteeing people’s right to food. Agricultural production is the first right to food material guarantee. Ensuring agricultural production is ensuring people’s right to food, their food security or at least the minimum necessary to avoid hunger. The aim is to systematize environmental risks sustainable management concepts and characteristics applied in agricultural production to guarantee the right to food. The environmental risk’s sustainable management entails an efficient use of financial and economic resources in agricultural production to prevent or reduce the environmental risk identified impact. The research establishes some general points of environmental risks sustainable management in agricultural production to guarantee the right to adequate food. The following research methods and techniques were selected: the theoretical-legal and document analysis.