bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREVALENCE OF MASKED HYPERTENSION IN CHILDREN AND YOUNG ADULTS WITH CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Goulas Ioannis , Evripidou Kleo , Doundoulakis Ioannis , Nika Thomai , Chainoglou Athanasia , Stabouli Stella 
Published: June 2022

Objective:
Hypertension is a common complication and an important risk factor for adverse cardiovascular outcomes in patients with chronic kidney disease (CKD). Studies characterizing blood pressure status on young renal transplant recipients and young dialysis patients using ambulatory blood pressure monitoring are limited and report different prevalence rates. The aim of this meta-analysis was to estimate the prevalence of white-coat and masked hypertension in children and young adults with chronic kidney disease.

Design and method:
We performed a systematic review and meta-analysis of observational studies assessing the prevalence of blood pressure status using ambulatory blood pressure monitoring in children and young adults with chronic kidney disease. Records were identified by search in Medline, Scopus, and CENTRAL databases and sources of grey literature until December 2021. We conducted a random-effects meta-analysis of proportions (double arcsine transformation).

Results:
Overall, we included 10 studies with a total of 1140 children and young adults with CKD and a mean age of 13.79 ± 4.35 years. 301 and 76 patients presented masked hypertension and white-coat hypertension, respectively. We estimated an overall pooled masked HTN prevalence of 27% (95% CI: 18% to 36%, I2 = 87%) and an overall pooled prevalence of white-coat HTN of 6% (95% CI: 3% to 9%, I2 = 78%) (figure 2). Among renal transplant recipients masked HTN had a prevalence of 29% (95% CI: 14% to 47%, I2 = 86%). Further assessment of heterogeneity was qualitatively conducted.

Conclusions:
Masked hypertension is significantly prevalent in children and young adults with CKD, thereby warranting clinical attention when assessing cardiovascular risk in this population. Ambulatory blood pressure monitoring is of high importance when assessing blood pressure status in children with CKD.
CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINES LEFT VENTRICULAR MASS INDEX IN CHILDREN ON DIALYSIS
Authors: Stabouli Stella , Askiti Varvara , Chainoglou Athanasia , Malakasioti Georgia , Chrysaidoy Katerina , Mila Maria , Karava Vasiliki , Marinaki Smaragdi , Kotsis Vasilios , Mitsioni Andromachi 
Published: June 2022

Objective:
Cardiovascular disease is highly prevalent in the chronic kidney disease population. The aim of the present study was to assess data from 24 h ambulatory blood pressure (BP) monitoring and 24 h pulse wave analysis (PWA) in dialyzed children and investigate their association with left ventricular mass as a marker of increased cardiovascular risk.

Design and method:
Children and adolescents aged 6 to 18 years, on dialysis for more than 12 months, [16 on peritoneal dialysis (PD) and 12 on hemodialysis (HD)], underwent 24 h ambulatory BP monitoring, 24 h PWA, and echocardiography. The population represents the whole pediatric dialysis cohort in Greece for the years 2019-2020.

Results:
Left ventricular mass index (LVMI) levels and prevalence of left ventricular hypertrophy (LVH) were similar between PD and HD patients. Peripheral and central BPs, and pulse wave velocity (PWV) values were also similar between PD and HD patients. However, HD patients presented significantly higher augmentation index (AIx75) (30.54 ± 6.14 vs 22.10 ± 9.96 %, p < 0.05), cardiac index (CI) (4.35 ± 0.90 vs 3.35 ± 0.54 l/m2, p < 0.005) and heart rate (94.20 ± 9.39 vs 84.92 ± 12.61 beats/min, p < 0.05) compared to the PD patients. Mean arterial pressure (MAP) z score (R2 = 0.34, P < 0.005), SBP/DBP dip (R2 = 0.21 and R20.22, respectively, P < 0.05), central systolic BP (cSBP) z score (R2 = 0.39, P < 0.001), PWV (R2 = 0.26, P = 0.005), CI, (R2 = 0.14, P < 0.05), AIx (R2 = 0.26, P = 0.005) associated with LVMI. Among laboratory parameters only Hb levels associated with LVMI. In stepwise linear regression with dependent variable LVMI and covariates Hb, MAP, SBP/DBP dip, cSBP, PWV, CI, AIx, the parameter that independently associated with LVMI levels was cSBP (B = 2.68, 95%CI 1.45–3.91, p < 0.001). All children with LVH in the PD group and 50% with left ventricular hypertrophy in the HD group had high cSBP (>95th pc).

Conclusions:
cSBP is the major determinant of LVMI levels in children on dialysis. Performing PWA seems to have an important role on the assessment of CV risk in children on dialysis.
SCHOOL HEALTH EDUCATION PROGRAM IN PAKISTAN (SHEPP)-FINDINGS FROM A FEASIBILITY TRIAL IN SCHOOL CHILDREN FROM A LOWER MIDDLE-INCOME COUNTRY
Authors: Almas Aysha , Iqbal Romaina , Ghani Abdul , Samad Zainab , Sabir Sania , Kazmi Khawar 
Published: June 2022

Objective:
The school environment plays an essential role in promoting health education and physical activity for children and adolescence, which they adapt into their adulthood. We aim to test feasibility of threefold health education program in children and its potential efficacy on physical activity and diet and cardio metabolic risk factors by including BP, BMI, and waist circumference.

Design and method:
The SHEPP was a parallel group feasibility intervention trial conducted in 2 schools over a 23 month period. All children aged 9–11 years enrolled from the above-mentioned schools were included. The SHEPP Intervention comprised of health education on healthy lifestyle and physical activity sessions for children, training of teachers and awareness sessions for parents conducted over 10 months. Primary outcome was feasibility of SHEPP in terms of recruitment, retention, and treatment fidelity. Secondary outcomes were physical activity levels, dietary intake (of fruits, vegetable), and cardio metabolic risk factors (blood pressure, BMI, and waist circumference (WC)

Results:

Results:
A total of 1280 preadolescent children were assessed for eligibility and 1191 were found eligible. The overall recruitment n (%) was 982/1191(82.5 %) with 505(51.4) from SHEPP intervention school and 477(48.6) in Routine Activity school. The overall retention rate n (%) at 10 month follow up was 912/982(92.8), with 465/505(92) in SHEPP intervention school and 447/477(93.7) in routine activity school. In treatment fidelity 132/144(92) %) Physical activity sessions and all (100%) health education sessions were conducted for each of the 12 classes. There was increase by134(196) minutes in the SHEPP intervention school v 29.8(177) in the routine activity school (P value < 0.001).The increase in out of school physical activity component of physical activity was more compared to in In school Physical activity from baseline to follow-up (101.0(187) v 33(27)). Overall, there was increase in vegetable intake n (%) (>3 serving /day) in SHEPP intervention school (28(5.5) to 108(21.4)) from baseline to follow-up compared to routine activity school (36(7.5) to 71(14.9)).

Conclusions:
We found that intervention using SHEPP is feasible in schools and may help children to carry healthy lifestyle in adulthood by increasing physical activity.
ANDROGEN DEFICIENCY ASSOCIATES WITH INCREASED ADVANCED GLYCATED END PRODUCTS, GALECTIN-3 IN HYPERTENSIVE MEN WITH BENIGN PROSTATIC HYPERPLASIA
Authors: Sirenko Oksana , Kuryata Olexandr 
Published: June 2022

Objective:
The aim of the study was to estimate the interaction between testosterone level with advanced glycation end products, galectin-3 in hypertensive men.

Design and method:
The study included 38 men with hypertension and benign prostatic hyperplasia. Advanced glycation end products, matrix metalloproteinases-9 activ¬ity, galectin-3, C-reactive protein, testosterone level were determined in all of patients. The 1st group was made up of men with hypertension and benign prostatic hyperplasia with testosterone deficiency; 2nd group – of men without testosterone deficiency.

Results:
Men with hypertension and benign prostatic hyperplasia with testosterone deficiency had a significantly higher level of advanced glycation end products, galectin-3 (p < 0.001). The presence of androgen deficiency in hypertensive men with benign prostatic hyperplasia was associated with increased levels of advanced glycation end products (OR = 2.8, p < 0.001), galectin-3 (OR = 2.2, p < 0.001).

Conclusions:
testosterone deficiency in hypertensive men with benign prostatic hyperplasia is associated with increased serum advanced glycation end products, galectin-3.
CLINICAL CHARACTERISTICS OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN A SPECIALIZED HOSPITAL
Authors: Kedelbaeva Kamilya , Berkinbaev Salim , Dzhunusbekova Gulnar , Tundybaeva Mira , Kabdulkaeva Aliya , Samitova Sabina , Ormanbek Aida , Duisenova Zhanylsyn , Akbarova Assem 
Published: June 2022

Objective:
To study the features of the clinical course of AMI.

Design and method:
A retrospective study of medical records of patients with AMI included 754 patients. Statistical processing was carried out using the SPSS 13 software (IBM, USA). Variables with parametric distribution are presented as x ± SD. To compare qualitative variables, the Pearson Chi-square test was used. Differences in the data were considered statistically significant at p < 0.05.

Results:
84.1% patients with a favorable outcome of AMI and 15.9% were fatal cases. In the analysis elderly people prevailed. For men 65 (± 11.3), for women 72 (± 10.1) years, p = 0.001. Obesity was observed more often in men than in women (35% vs. 26%; p < 0.001). Dyslipidemia occurred more often in men than in women (57.5% vs. 42.5%; p = 0.525). CKD, AF, DM were predominantly diagnosed in women compared with men (58.8% vs. 41.2%; p = 0.001; 15.8% vs. 10.8%; p = 0.049; 54.9% vs. 45.1%; p = 0.001). The frequency of CHF, AH, repeated AMI was higher in men (65.5% versus 34,%; p = 0.35, AH 58.2% versus 41.8%; p < 0.001, repeated AMI 62, 4% versus 37.6%; p = 0.520). The proportion of men who underwent CABG was higher than that of women (13.3% versus 9.2%: p = 0.176). In addition, men were more likely to undergo PCI and further stenting (85.7% versus 78.1%; p = 0.007; stenting. 58.9% versus 48%; p = 0.006). In the duration of hospitalization men lay longer than women (11 (+ - 4.05) versus 9.5 (+ - 4.2) p = 0.003). Fatalities were higher in women - 52.5%, among men it was 47.5% (p = 0.005).

Conclusions:
Unfavorable risk factors for the development of AMI were more often identified among men. Comorbid diseases such as diabetes, AF, CKD were more common in women than in men. AH, CHF, repeated AMI were more detected in men. Therapeutic procedures such as CABG, PCI and stenting were performed more in men. In terms of hospitalization terms, the men stayed in the hospital longer.
ASSESSMENT OF THE SEVERITY OF THE DEGREE OF CONCOMITANT NOSOLOGIES ACCORDING TO THE CHARLSON INDEX IN PATIENTS WITH MYOCARDIAL INFARCTION
Authors: Kedelbaev Kamilya , Berkinbaev Salim , Dzhunusbekova Gulnar , Tundybaeva Mira , Duisenova Zhanylsyn , Ormanbek Aida , Akbarova Assel , Samitova Sabina 
Published: June 2022

Objective:
Determination of the severity of comorbid pathology in patients with acute myocardial infarction.

Design and method:
The retrospective study included 634 medical records of a patient with myocardial infarction. Statistical processing was carried out using the SPSS 13 software. To compare qualitative variables, the Pearson 2 test was used for paired values. Differences in the data were considered statistically significant at p < 0.05. To compare the groups, we used the ANOVA test. One-way Pearson correlation analysis was carried out.

Results:
The comorbidity of AMI patients was assessed using the Charlson comorbidity index. The patients were divided into 3 groups: Group I (low comorbidity, CI < 3 points) accounted for 4.4% of the patient; Group II (average comorbidity, CI 3–5 points) - 48.3% of the patient; Group III (high comorbidity, CI more 5 points) - 47.3% of the patient. Charlson’s comorbidity index was 5.5 ± 1.9 points. The total number of nosologies in AMI patients also increased with age (r = 0.741, p = 0.001). Low comorbidity was found in 92.9% of men and 7.1% of women. Average comorbidity: 75.2% and 24.8%, respectively. Patients with a high Charlson comorbidity index were defined in the same way in 49.7 % men and 50.3% women, p = 0.0001. Patients with high comorbidity were more likely to have anemia than patients with low comorbidity. 28.3% and 10.7% cases, pIII – I = 0.0001. It was also revealed that the higher the comorbidity index was, the higher the troponin level was (p = 0.024).

Conclusions:
In the studied patients with AMI, a high degree of severity of comorbidity was determined. The total number of nosologies in AMI patients increased with age. High comorbidity, which increased with age, was defined in the same way in both men and women. Patients with a high severity of comorbidity was level of troponin in the blood was higher, possibly related to age, which is associated with a worse hospital prognosis. When calculating the comorbidity index, Charlson showed a low 10-year survival rate of our patients (21%).
ASSOCIATION BETWEEN THE PRESENCE OF COMORBIDITIES AND CARDIOVASCULAR OUTCOMES IN A HYPERTENSIVE LATIN AMERICAN POPULATION
Authors: de Sousa Andrea , Magalhães Fabrício Galdino , da Silva Suelen Benta , Inuzuka Sayuri , Teixeira Maria Emília , Batista Sandro Rodrigues , Barroso Souza Weimar Kunz Sebba , Sousa Ana Luiza Lima 
Published: June 2022

Objective:
To analyze the association between the presence of comorbidities and cardiovascular outcomes in hypertensive Latin American patients.

Design and method:
A cross-sectional study with a sample of patients from the First Brazilian Hypertension Registry (I RBH), that recruited patients aged 18 and over, diagnosed with hypertension for at least 4 weeks. Participants were followed for one year in public and private services. Comorbidities were categorized as hypertension associated with diabetes mellitus or dyslipidemia (2 morbidities) and hypertension with diabetes mellitus and dyslipidemia (3 morbidities). The association of morbidity combinations with the following cardiovascular outcomes was performed: acute myocardial infarction, angina, heart failure and myocardial revascularization. Data were analyzed using the chi-square test and a significance level of p < 0.05.

Results:
The sample consisted of 2.642 patients aged 61 ± 11.8 years. Within the evaluated sample of hypertensive patients, dyslipidemia (46.9%) was the most prevalent, followed by diabetes mellitus (29.7%). The triad hypertension, diabetes and dyslipidemia was present in 19% of participants and responded for the highest prevalence of cardiovascular outcomes: acute myocardial infarction (21.7%, p < 0.001), angina (7.8%, p = 0.02), heart failure (7.6%, p < 0.001) and myocardial revascularization (14.7%, p < 0.001).

Conclusions:
Acute myocardial infarction was the most present outcome among hypertensive and diabetic patients. Cardiovascular outcomes were associated with of other morbidities in addition to hypertension.
BLOOD PRESSURE AND OTHER CLINICAL CHARACTERISTICS OF PATIENTS WITH MYOCARDIAL INFARCTION UNDER 50 YEARS OF AGE
Authors: Kamasova Monika , Kocianova Eva , Obrova Jana , Gizelova Nikola , Kvapil Tomas , Jelinek Libor , Taborsky Milos 
Published: June 2022

Objective:
Arterial hypertension is the main risk factor for the development of cardiovascular diseases throughout the world. The prevalence of acute myocardial infarction (AMI) is increasing in young adults, especially men. Previous studies have identified that risk factors for AMI included tobacco use, obesity, arterial hypertension, and diabetes may be crucial to young individuals. Compared to the elderly, the risk factors are not well studied among the young patients with AMI.

Design and method:
We enrolled to our study 41 patients younger than 50 years (thirty-six men) admitted to the Department of Internal I - Cardiology, University Hospital Olomouc, with first episode AMI. We collected detailed information regarding family history of premature CVD (MI/ischaemic stroke in men aged < 55 and in women aged < 65 years, body mass index (BMI), smoking, hypertension, dyslipidemia, diabetes mellitus (DM). Hypertension was defined, according to ESH/ESC (European Society of Hypertension, European Society of Cardiology) guidelines, based on repeated blood pressure measurements, medical history and ongoing blood-pressure-lowering treatment.

Results:
Among 41 young patients with AMI (average 46 ± 3,4 years old), 15 patients (36,6%) had a known diagnosis of arterial hypertension prior to admisison. Mean level of systolic blood at admission were 128,6 ± 18,22 mmHg, diastolic blood pressure 81,35 ± 12,49 mmHg, mean heart rate was 76,32 ± 13,11 bpm. Uncontrolled arterial hypertension was diagnosed at admision in 6 patients, newly diagnosed hypertension in 4 patients. In our group, we diagnosed ST-elevation MI (STEMI) in 54 % of patients, NSTEMI in 46%. Mean level of TRPI was 24051,43 ± 32860,98 ng/l, NTproBNP was 731,1 ± 1019,92 pg/ml. Mean LDL-cholesterol was 3,26 ± 0,83 mmol/l. We newly diagnosed diabetes mellitus in 2 patients, mean HbA1c was 38,42 ± 9,43 (mmol/mol).

Conclusions:
In our group of young patients with myocardial infarction was prevalence of uncontrolled hypertension 17%. Compared to a group of healthy patients (data from literature), we found out a higher prevalence of arterial hypertension in our group.
FEATURES AND IN-HOSPITAL PROGNOSIS OF REDUCED OR PRESERVED EJECTION FRACTION IN ST-SEGMENT ELEVATION MYOCARDIAL INFRACTION MANAGED BY PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Chamtouri Ikram , Amdouni Nesrine , Abdallah Wajih , Jomaa Walid , Ben Hamda Khaldoun , Maatouk Faouzi 
Published: June 2022

Objective:
to assess features and in-hospital prognosis in STEMI patients treated by PPCI and presenting reduced or preserved LVEF.In-hospital mortality and complications were compared between patients with preserved or reduced LVEF

Design and method:
All patients admitted for STEMI between 2000 and 2019 and treated by PPCI were enrolled. On-admission echocardiography was performed in all patients after PPCI to determine LVEF.In-hospital mortality and complications were compared between patients with preserved or reduced LVEF

Results:
A total of 725 was studied. Mean age was 59.1 ± 12.2 years old and 148 (20.4%) were female. Diabetes, hypertension, obesity and tobacco consumption represented 36%, 26.9%, 41.1% and 67.7% respectively. Reduced LVEF< 50% was diagnosed in 324 patients (44.7%). In-hospital mortality was significantly higher in patients with reduced LVEF compared to patients with preserved LVEF on-admission. In-hospital outcomes including atrial fibrillation, ventricle tachycardia and fibrillation, atrioventricular block and pericardial effusion were significantly higher in reduced LVEF.

Conclusions:
Patients presented STEMI managed by PCI and presenting reduced LVEF on admission are more exposed to in-hospital mortality and complications.
GENDER-RELATED DIFFERENCES IN CORONARY ARTERY DISEASE IN PATIENTS WITH RESISTANT HYPERTENSION
Authors: Solimene Maria Cecilia , Drager Luciano , Bortolotto Luiz 
Published: June 2022

Objective:
Hypertension (HTN) is a major risk factor for cardiovascular disease (CVD). Gender differences in clinical aspects of CVD do exist and women seem to have poorer outcomes as compared to men. However the evidence regarding gender-related prognosis in the HTN scenario is controversial. Resistant HTN (RH) in women has been associated to a high increased risk of long-term CV events including death.
We aim to evaluate gender differences in the occurrence of obstructive coronary artery disease (CAD) in patients (pts) with RH and suspected symptoms/signs of CAD referred to cath lab.

Design and method:
Patients were retrospectively included based on admission at Hypertension Department of a tertiary Academic Hospital from May/2010 through May/2014. RH was defined as blood pressure (BP) > = 140/90 mmHg on > 3 anti-HTN drugs or BP< 140/90 mmHg using > = 4 drugs.

Results:
From a total of 1519 pts (883 pts excluded due incomplete data), a final cohort of 634 was established, 357(56,3%) women, mean age 52.5 ± 11 years, body mass index 30.4 ± 6 kg/m2, BP at admission 171 ± 29 / 101 ± 17 mmHg, on use of 3.5 ± 1 anti-HTN drugs. From these, 186 (30%) pts were submitted to coronary angiography. Diagnosis of CAD (coronary stenosis > 50% in at least one major vessel) was made in 113(60%) pts, 45% women. The only risk factor associated to CAD in men was diabetes (38%-CAD vs. 17% non-CAD), while in women the presence of CAD was significantly (p< 0.05) related to the presence of dyslipidemia (72%-CAD vs 46%-non CAD), family of history of CAD (56%-CAD vs 27%-non CAD), age (57yrs-CAD vs. 50 yrs-non CAD), hypertriglyceridemia (176 mg/dl -CAD vs. 114 mg/dl-non CAD), blood glucose (142 mg/dl -CAD vs. 109 mg/dl-non CAD) and lower glomerular filtration rate (58 ml.min.1.73 m2- CAD vs 73 ml.min.1.73 m2-no CAD).

Conclusions:
In pts with RH, the prevalence of CAD is higher in women than expected. There are gender differences regarding risk factors related to CAD in RH, where diabetes was the only CAD risk factor in men, while dyslipidemia and chronic kidney disease are significant risk factors for women, challenging current knowledge
ACUTE ST-ELEVATION MYOCARDIAL INFARCTION: ARE MEN AND WOMEN PARTICULAR CASES OF STEMI?
Authors: Duarte Fabiana , Santos Inês , Barradas Maria Inês , Oliveira Luís , Fontes António , Monteiro André , Machado Carina , Dourado Raquel , Santos Emília , Pelicano Nuno , Pacheco Miguel , Tavares Anabela , Martins Dinis 
Published: June 2022

Objective:
To access the difference in clinical characteristics and prognostic outcomes between men and women who were admitted in our Cardiac Intensive Care Unit with STEMI diagnosis.

Design and method:
We retrospectively analyzed 121 patients with STEMI, during a mean follow-up period 135 ± 31 weeks.
We accessed baseline characteristics and time course of events.
Primary endpoint (PE) was a composite of in-hospital cardiovascular death, arrhythmic events or STEMI evolution in Killip-Kimbal III or IV.
Secondary endpoint (SE) was in-hospital major bleeding events and tertiary endpoint (TE) included admissions to the emergency department or hospitalization by heart failure decompensation, acute or chronic coronary syndromes and all-cause mortality.

Results:
Of the 121 patients, 102 were male (84.3%). The mean age was 58.3 ± 12.7 years and women had a superior mean age (69.8 ± 12.2 years).
Hypertension was more prevalent in women (84.2% vs. 47.1%, respectively; p 0.003) and also diabetes – 36.8% of women had type 2 diabetes and 5.3% of these female patients requires insulin therapy (vs 2% of men; p 0.021).
According to Charlson Comorbidity Index (CCI), women had a higher disease burden with 73.7% of them included into the moderate or severe group of mortality risk, compared to 42.2% of men (p 0.014).
Conversely, less women smoke (31.6% vs. 82.2%; p < 0.001) and less frequently chest pain was the onset symptom (78.9% vs. 95.1%; p 0.04).
Time since symptom onset to door admission was estimated on 510 ± 1149 minutes and the mean women delay was superior (557 ± 858 minutes).
Regarding to in-hospital hemorrhagic events, female patients had a statistically significant higher risk (22.2% vs. 7.1%, p 0.045), independently of hypertension, diabetes or anticoagulant therapy (r = 0.249; ANOVA p-value < 0.005), but it was associated with higher CCI (p 0.033). No other gender differences in outcomes were observed.

Conclusions:
Our study demonstrates gender-related differences among patients with STEMI. Indeed, women were older, had more clinical cardiovascular risk factors and tend to delay hospital admission after symptoms onset. Secondary endpoint was statistically more frequent in women, but no other differences in outcomes were observed.