bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor
Authors: Zhou Zhanwei , Liang Huan , Yang Ruoxi , Yang Ying , Dong Jingwen , Di Yongxiang , Sun Minjie 
Published: March 2022

AbstractThe abundant glutathione (GSH) in “cold” tumors weakens ferroptosis therapy and the immune response. Inspired by lipids, we fabricated cinnamaldehyde dimers (CDC) into lipid‐like materials to form dimersomes capable of depleting GSH and delivering therapeutics to potentiate the ferroptosis and immunotherapy of breast cancer. The dimersomes exhibited superior storage stability for over one year. After reaching the tumor, they quickly underwent breakage in the cytosol owing to the conjugation of hydrophilic GSH on CDC by Michael addition, which not only triggered the drug release and fluorescence switch “ON”, but also led to the depletion of intracellular GSH. Ferroptosis was significantly enhanced after combination with sorafenib (SRF) and elicited a robust immune response in vivo by promoting the maturation of dendritic cells and the priming of CD8+ T cells. As a result, the CDC@SRF dimersomes cured breast cancer in all the mice after four doses of administration.
Antibacterial metabolites from an unexplored strain of marine fungiEmericellopsis minimaand determination of the probable mode of action againstStaphylococcus aureusand methicillin‐resistantS. aureus
Authors: Agrawal Shivankar , Dufossé Laurent , Deshmukh Sunil Kumar 
Published: March 2022

AbstractIncreasing prevalence of drug resistance has led researchers to focus on discovering new antibacterial agents derived from the marine biome. Although ample studies have investigated marine fungi for their bioactive metabolites with hopeful prospects in drug discovery. The present study was aimed to isolate/ identify potential antimethicillin‐resistantStaphylococcus aureuscompounds producing marine fungal strain from the Indian marine environment. The effective anti‐MRSA compound was produced by a marine fungal strain designated as D6. The D6 strain exhibited 99% similarity toEmericellopsis minimabased on 18S rRNA gene analysis. The culture conditions ofE. minimaD6 were optimized using nutritional and environmental parameters for enhanced anti‐MRSA compound production. The agar well diffusion assay was used to determine the inhibition zone diameter of the crude extract againstS. aureusand methicillin‐resistantS. aureus, whereas the broth microdilution method was used to determine their minimum inhibitory concentration (MIC) active fraction. MIC values of the ethyl acetate fraction ranged from 0.8 to 1 mg/mL. SEM analysis revealed that the ethyl acetate fraction induces deep craters in methicillin‐resistantS. aureus. Further, GC‐MS analysis confirmed the occurrence of a total of 15 major compounds in active ethyl acetate fraction. Some of the major antibacterial compounds included cyclopentanol, isothiazole, benzoic acid, pyrrolo[1,2‐a] pyrazine‐1,4‐dione, and hexahydro. These findings suggest that the marine fungi ofE. minimacan be a valuable candidate for prospecting antibiotics and an alternative complementary strategy for drug‐resistant bacterial infections.
Carboxymethyl chitosan prolongs adenovirus‐mediated expression of IL‐10 and ameliorates hepatic fibrosis in a mouse model
Authors: Gou Yannian , Weng Yaguang , Chen Qian , Wu Jinghong , Wang Hao , Zhong Jiamin , Bi Yang , Cao Daigui , Zhao Piao , Dong Xiangyu , Guo Meichun , Wagstaff William , Hendren‐Santiago Bryce , Chen Connie , Youssef Andrew , Haydon Rex C. , Luu Hue H. , Reid Russell R. , Shen Le , He Tong‐Chuan , Fan Jiaming 
Published: March 2022

AbstractEffective and safe liver‐directed gene therapy has great promise in treating a broad range of liver diseases. While adenoviral (Ad) vectors have been widely used for efficacious in vivo gene delivery, their translational utilities are severely limited due to the short duration of transgene expression and solicitation of host immune response. Used as a promising polymeric vehicle for drug release and nucleic acid delivery, carboxymethyl chitosan (CMC) is biocompatible, biodegradable, anti‐microbial, inexpensive, and easy accessible. Here, by exploiting its biocompatibility, controlled release capability and anti‐inflammatory activity, we investigated whether CMC can overcome the shortcomings of Ad‐mediated gene delivery, hence improving the prospect of Ad applications in gene therapy. We demonstrated that in the presence of optimal concentrations of CMC, Ad‐mediated transgene expression lasted up to 50 days after subcutaneous injection, and at least 7 days after intrahepatic injection. Histologic evaluation and immunohistochemical analysis revealed that CMC effectively alleviated Ad‐induced host immune response. In our proof‐of‐principle experiment using the CCl4‐induced experimental mouse model of chronic liver damage, we demonstrated that repeated intrahepatic administrations of Ad‐IL10 mixed with CMC effectively mitigated the development of hepatic fibrosis. Collectively, these results indicate that CMC can improve the prospect of Ad‐mediated gene therapy by diminishing the host immune response while allowing readministration and sustained transgene expression.
The double injection technique to improve visualization of severe coronary lesions with optical coherence tomography
Authors: Rivero Fernando , Marco Valeria , Biccirè Flavio Giuseppe , Budassi Simone , Cuesta Javier , del Val David , Bastante Teresa , de la Fuente Hortensia , Prati Francesco , Alfonso Fernando 
Published: March 2022

AbstractBackgroundOptical coherence tomography (OCT) is a high‐resolution imaging modality that provides a precise evaluation of coronary anatomy. However, the presence of severe coronary lesions can prevent the required adequate distal contrast flushing resultting in inadequate blood clearance and poor image quality or complete blood shadowing of the underlying vessel wall.ObjectivesThe aim of this prospective study was to evaluate the feasibility and safety of a novel “double injection technique” (DIT) to overcome the limitations of the conventional technique (CT) in patients with severely stenotic lesions.MethodsTwenty‐three patients with severe angiographic lesions were sequentially imaged before intervention with OCT with the CT and then with DIT. A total of 5125 OCT frames were carefully matched and analyzed by an independent central core lab. A semiquantitative image quality score was used to grade the number of quadrants (0–4) with vessel wall visualization.ResultsOptimal OCT visualization (Grades 3–4) significantly improved by the DIT (68% vs. 38% of frames, p < 0.001). The DIT also improved the mean score (3.1 ± 0.6 vs. 2.0 ± 0.8; p < 0.05; mean improvement of 1.1 ± 0.5 per patient). There were no complications associated with the DIT.ConclusionThe DIT significantly improved preintervention image quality of OCT in severe coronary lesions.
Not all pseudoaneurysms are femoral—A transcaval transcatheter aortic valve replacement rare complication
Authors: Mano Tânia B. , Ramos Rúben , Cacela Duarte , Patrício Lino 
Published: March 2022

AbstractWe report a case of a 73‐year‐old male with multiple comorbidities, including postpoliomyelitis severe scoliosis, referred to our tertiary center due to a severe symptomatic aortic stenosis, considered high risk for surgical aortic valve replacement (AVR). Due to unsuitable femoral and subclavian accesses, the patient underwent a transcaval transcatheter AVR (TAVR) procedure, complicated by the development of an iatrogenic infrarenal aortic pseudoaneurysm with aortocaval fistula. Scoliosis can cause varying anatomic relationships between retroperitoneal vessels and intervertebral disk spaces, which increase the difficulty of the procedure and consequently lead to this vascular complication. Although most aortocaval fistulas close spontaneously after 1 year, the risk of pseudoaneurysm rupture in this critical area was crucial in the decision of a new successful percutaneous aortic stent intervention.
How Cation Substitutions Affect the Oxygen Reduction Reaction on La2−xSrxNi1−yFeyO4
Authors: Whittingham Alexander W. H. , Liu Xinran , Smith Rodney D. L. 
Published: March 2022

AbstractThe atomic proximity of two disparate structural motifs in interleaved structures such as that adopted by La2NiO4, which alternates rock salt and perovskite motifs, offers potential synergistic effects and increased tunability for electrocatalyst behavior. Structural and voltammetric analysis of the intersecting composition series LaSrNi1−yFeyO4+δ and La2−xSrxNi0.7Fe0.3O4+δ show that tuning different cation sites uniquely affects structure and behavior. Correlations between X‐ray diffraction and Raman spectroscopy results reveal that structural changes in the a‐b plane are uniformly matched by the c‐axis following La−Sr exchange, while Ni−Fe exchange distorts the structure by expanding the crystal c‐axis and generating oxygen defects with a distinct signature in Raman spectra. Correlations between rotating ring‐disk electrode voltammetry results and structural parameters show that only Fe substitution has a direct effect on the electrocatalytic oxygen reduction reaction. We link systematic changes observed for onset of electrocatalytic oxygen reduction reaction, Tafel slope, and selectivity to distortions in the B‐site environments. This analysis demonstrates that correlational analysis linking electrochemical behavior parameters to multiple structural characterization techniques is an effective means to probe the effect of individual compositional substitution on electrocatalytic behavior.
Tracking Passivation and Cation Flux at Incipient Solid‐Electrolyte Interphases on Multi‐Layer Graphene using High Resolution Scanning Electrochemical Microscopy
Authors: Zeng Yunxiong , Gossage Zachary T. , Sarbapalli Dipobrato , Hui Jingshu , Rodríguez‐López Joaquín 
Published: March 2022

AbstractThe solid electrolyte interphase (SEI) is a dynamic, electronically insulating film that forms on the negative electrode of Li+ batteries (LIBs) and enables ion movement to/from the interface while preventing electrolyte breakdown. However, there is limited comparative understanding of LIB SEIs with respect to those formed on Na+ and K+ electrolytes for emerging battery concepts. We used scanning electrochemical microscopy (SECM) for the in situ interfacial analysis of incipient SEIs in Li+, K+ and Na+ electrolytes formed on multi‐layer graphene. Feedback images using 300 nm SECM probes and ion‐sensitive measurements indicated a superior passivation and highest cation flux for a Li+‐SEI in contrast to Na+ and K+‐SEIs. Ex situ X‐ray photoelectron spectroscopy indicated significant fluoride formation for only Li+ and Na+‐SEIs, enabling correlation to in situ SECM measurements. While SEI chemistry remains complex, these electroanalytical methods reveal links between chemical variables and the interfacial properties of materials for energy storage.
Effect of Pitch Coating on SiOx Alloy/Spherical Artificial Graphite Composites as Anode Materials for Lithium‐Ion Batteries
Authors: Im Ui‐Su , Hyeon Yun Jae , Ung Hwang Jin , Jun Ahn Won , Kim Myungjae , Sun Im Ji 
Published: March 2022

AbstractSiOx‐based anodes are attracting intensive attention with the increasing demand for high‐energy‐density lithium‐ion batteries (LIBs). Since the theoretical capacity of SiOx is superior to that of graphite and its volume deformation is more stable than that of silicon, tremendous efforts are applied to design various SiOx‐based anode materials. However, industrially utilizing SiOx‐based anodes is still insufficient owing to volume deformation, low initial coulombic efficiency and poor cycle life. Thus, this work develops a pitch‐coated SiOx/graphite (P@SiOx@G) composite constructed with the optimal ratio between SiOx and graphite under the collaborative auxiliary of pitch coating to serve as a buffer against volume deformation and to improve the discharge rate performance. The electrode thicknesses of P@SiOx‐10@G‐900 increases by approximately 18.6 % from 43.32 μm to 51.36 μm after 70 cycles, respectively. However, in SiOx@G, the electrode experiences delamination due to volume expansion during lithiation/delithiation of SiOx. Notably, P@SiOx‐10@G‐1100 shows an outstanding initial coulombic efficiency of 86.4 % and a high capacity retention rate (at 200 mA g−1 after 100 cycles) of approximately 96 %. This result is mainly due to the uniform and thin solid electrolyte interphase (SEI) layer on the SiOx/graphite composite.
Ni‐Catalyzed Cross‐Coupling of 2‐Iodoglycals and 2‐Iodoribals with Grignard Reagents: A Route to 2‐C‐Glycosides and 2’‐C‐Nucleosides
Authors: Polák Peter , Cossy Janine 
Published: March 2022

AbstractThe synthesis of 2‐C‐glycals and 2‐C‐ribals was achieved in good yields using a nickel‐catalyzed cross‐coupling between 2‐iodoglycals and 2‐iodoribal respectively and Grignard reagents. The prepared 2‐C‐glycals and ribals were then transformed into 2‐C‐2‐deoxyglycosides, 2‐C‐diglycosides and 2’‐C‐2’‐deoxynucleosides. The developed method was applied to the synthesis of a 2‐chloroadenine2’‐deoxyribonucleoside – a structural analogue of cladribine (Mavenclad®, Leustatin®) and clofarabine (Clolar®, Evoltra®), two compounds used in the treatment of relapsing‐remitting multiple sclerosis and hairy cell leukemia.
Enantioselective Organophotocatalytic Telescoped Synthesis of a Chiral Privileged Active Pharmaceutical Ingredient
Authors: Herbrik Fabian , Sanz Miguel , Puglisi Alessandra , Rossi Sergio , Benaglia Maurizio 
Published: March 2022

AbstractThe continuous flow, enantioselective, organophotoredox catalytic asymmetric alkylation of aldehydes was studied, by using a homemade, custom‐designed photoreactor for reactions under cryogenic conditions. Going from microfluidic conditions up to a 10 mL mesofluidic reactor, an increase of productivity by almost 18000 % compared to the batch reaction was demonstrated. Finally, for the first time, a stereoselective photoredox organocatalytic continuous flow reaction in a fully telescoped process for an active pharmaceutical ingredient (API)synthesis was successfully achieved. The final process consists of four units of operation: visible light‐driven asymmetric catalytic benzylation under continuous flow, inline continuous work‐up, neutralisation and a final oxidative amidation step afforded the pharmaceutically active molecule in 95 % e.e.
Coupling of Heteroaryl Halides with Chlorodifluoroacetamides and Chlorodifluoroacetate by Nickel Catalysis
Authors: Zhang Dawei , Gao Xing , Min Qiao‐Qiao , Gu Yucheng , Berthon Guillaume , Zhang Xingang 
Published: March 2022

AbstractA nickel‐catalyzed cross‐coupling of heteroaryl halides with chlorodifluoroacetamides and chlorodifluoroacetate has been developed. The combination of NiCl2 ⋅ DME with 4,4′‐diNon‐bpy, co‐ligand PPh3, and additive LiCl renders the catalytic system efficient for the synthesis of medicinal interest heteroaryldifluoroacetamides. The application of the method leads to short and highly efficient synthesis of biologically active molecules, providing a facile route for applications in medicinal chemistry and agrochemistry.
Ideal‐Typical Utility Infrastructure at Chemical Sites – Definition, Operation and Defossilization
Authors: Bauer Thomas , Prenzel Marco , Klasing Freerk , Franck Rüdiger , Lützow Julian , Perrey Karen , Faatz Rainer , Trautmann Juliane , Reimer Andreas , Kirschbaum Stefan 
Published: March 2022

AbstractThe defossilization of the electricity and heat supply in the chemical industry poses a significant challenge. In particular, the intended feed‐in of volatile renewable electricity into the chemical processes may conflict with the need for a constant, secure and affordable electricity and heat supply for chemical plants. Adapted concepts for the operation of the cogeneration plant, which is located at the chemical site, play a central role. The present work defines a so‐called ideal‐typical utility infrastructure (iUI). The iUI is a means to exemplarily investigate the operational behavior of utility infrastructures and furthermore to identify defossilization options for process steam and electricity supply at chemical sites.
Wettbewerb für das ChemCar 2022 gestartet
Authors: Woppowa Ljuba 
Published: March 2022

AbstractDas Team Spring O2′clock der RWTH Aachen hatte mit einer ausgefeilten Kombination von Chemie und Mechanik den 16. ChemCar‐Wettbewerb des VDI gewonnen. Einreichungen für den 17. ChemCar‐Wettbewerb 2022 sind bis 1. April 2022 möglich.
Ich sehe das, was Du siehst ‐ mit der Datenbrille
Authors: Schnathmann Regina 
Published: March 2022

AbstractFlexibel reagiert: Als eine geplante Inbetriebnahme vor Ort auf Grund der Reisebeschränkungen durch die Corona‐Pandemie nicht durchgeführt werden konnte, stellte die BEUMER Group die Weichen auf Remote‐Commissioning – die Inbetriebnahme aus der Ferne. Das Pilotprojekt mit einer Verpackungslinie lief erfolgreich und bewahrte den Kunden vor möglichen Lieferengpässen und Marktverlusten.
Promoting remote workers' psychological health: Effective management practices during the COVID‐19 crisis
Authors: Bouchard Laurence , Meunier Sophie 
Published: March 2022

AbstractThe aim of this study was to identify specific management practices that promote the psychological health of remote workers in the context of the COVID‐19 crisis. A two‐round Delphi study was conducted among 28 teleworkers and 22 managers. A list of 60 specific management practices was presented and participants had to identify whether each one could be used in the current remote working context and, if so, how useful it was to promote psychological health at work. Results indicate that most specific management practices usually used in a face‐to‐face setting can also be used in a remote context (85%). Practices that show consideration, establishing work structure, and allowing flexibility were also identified as the most useful to promote remote workers' psychological health during the pandemic. This study contributes to the advancement of knowledge about specific management practices, remote working, and crisis management. It also suggests specific practices that managers can adopt to promote the psychological health of their employees during a period of crisis, even while managing from a distance.
Visual and photographic assessment of wine color
Authors: Fairchild Mark D. 
Published: March 2022

AbstractThis article presents a color chart explicitly designed for the visual color assessment of wines as a part of more comprehensive hedonistic or analytical tasting systems. The chart is based on visual, colorimetric, and in situ evaluations of existent wine color and the techniques for its assessment in wine sensory evaluation. The system is specified in Munsell coordinates and corresponding sRGB values. Its derivation and use is described and a photographic system for measurement‐based implementation of the system is introduced.
The effect of different levels of urea and planting density on the phytochemical characteristics, alkaloids, and yield of the medicinal plant jimsonweed (Datura stramonium L.)
Authors: Izadi Zahra , Biabani Abbas , Sabouri Hossein , Bahreininejad Babak 
Published: March 2022

AbstractDatura stramonium L. (jimsonweed) from the Solanaceae family is widely used in traditional medicine due to its medicinal properties. This paper investigated the effect of three levels of urea fertilizer (60, 120, and 180 kg ha–1) and three levels of planting density (6, 10, and 14 plants m−2) on the grain alkaloids, chlorophylls a and b content, carotenoids, anthocyanins, and grain and biological yields. A factorial experiment as a randomized complete block design was carried out at the Research and Education farm of Isfahan Agricultural and Natural Resources and Training Center in IRAN in 2018 and 2019. Significant differences were detected between urea levels and plant density for leaf chlorophyll content, carotenoids, and anthocyanins at the 1% probability. Also, hyoscyamine alkaloid levels and scopolamine content are affected by the urea levels at the 1% probability. Moreover, the relationship between phytochemical characteristics and alkaloids with the grain and biological yields in D. stramonium is investigated by path analysis. The results showed that grain yield, hyoscyamine alkaloid levels and scopolamine content is significantly improved by 6 plants m−2planting density and 180 kg ha–1 urea.
A self‐consistent mean‐field model for turbulent particle and heat transport in 2D interchange‐dominated electrostatic ExB turbulence in a sheath‐limited scrape‐off layer
Authors: Coosemans Reinart , Dekeyser Wouter , Baelmans Martine 
Published: March 2022

AbstractIn this paper, a self‐consistent model for the average radial turbulent transport of heat and particles in 2D anisothermal interchange‐dominated electrostatic ExB drift turbulence in sheath‐limited scrape‐off layers is presented. Diffusion models are used for the turbulent particle and heat fluxes, in which the transport coefficients scale with the square root of the turbulent kinetic energy (). The interchange drive proves to be the main source of turbulent kinetic energy, while the sheath term provides the main sink. These observations are qualitatively the same as for the isothermal case studied earlier. An analytical relation for the interchange term is derived, showing that the turbulent ExB thermal energy flux is the direct driver for through the interchange source. A series decomposition of the sheath term in the equation shows it includes a sink contribution that was also present in the isothermal case, but also a new source due to the sheath‐driven conducting‐wall (SCW) instability caused by electron temperature fluctuations. Using a simple regression model to close the total sheath term, a closed model for the turbulent transport is obtained. The interchange drive due to the ExB energy flux leads to a self‐saturation mechanism in the model, where the gradients and turbulence intensity increase until a sufficient transport level is reached to carry the power and particles across the field lines to find a balance with the sheath sink. An implementation of this model in a 1D mean‐field code approximates the profiles of the turbulence simulations with remarkable accuracy in part of the parameter space, while the error increases in parameter regimes where the relative importance of the SCW term is varied.
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p
Authors: Shi Tao , Li Rui , Duan Peng , Guan Yongjun , Zhang Dahu , Ding Zhiyong , Ruan Xianguo 
Published: March 2022

AbstractChemoresistance seriously hinders the treatment efficiency of human cancers, including prostate cancer (PCa). Multiple long noncoding RNAs (lncRNAs) were involved in drug resistance in PCa. We aimed to explore the function of transient receptor potential cation channel subfamily M member 2 (TRPM2) antisense RNA (TRPM2‐AS) in paclitaxel (PTX) resistance in PCa. Our results showed that TRPM2‐AS was increased in PTX‐resistant PCa cells. TRPM2‐AS knockdown accelerated cell apoptosis and inhibited cell proliferation, migration, invasion, and PTX resistance in PTX‐resistant PCa cells. MiR‐497‐5p was bound to TRPM2‐AS and its inhibition reversed the effects of TRPM2‐AS knockdown on cell progression and PTX resistance in PTX‐resistant PCa cells. FOXK1 was identified as a target of miR‐497‐5p and FOXK1 overexpression showed similar effects on cell progression and PTX resistance with miR‐497‐5p inhibition in PTX‐resistant PCa cells. In conclusion, TRPM2‐AS knockdown suppressed cell progression and PTX resistance in PTX‐resistant PCa cells by miR‐497‐5p/FOXK1 axis.