bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dermatofibrosarcoma protuberans of the anterior abdominal wall: case report and literature review
Authors: Souiki Tarik , Belhaj Anas , Ait Abderrhim Abderrahim , Alami Badreeddine , Tahiri Layla , Chbani Laila , Ibn Majdoub Karim , Toughrai Imane , Mazaz Khalid 
Published: June 2022

Abstract
Dermatofibrosarcoma protuberans (DFSP) is a rare and slowly growing cutaneous tumor with high risk of local invasion and recurrence. Here, we report a case of a DFSP of the anterior abdominal wall diagnosed in a 45-year-old woman. The clinical examination showed an indurated well-limited oval mass localized in the supra-umbilical level and measuring 5 cm by 3 cm. The histological finding of skin biopsy was consistent with the diagnosis of DFSP. A wide local excision was performed while respecting minimum safety margins of 3 cm. The primary closure was possible after advancing the subcutaneous adjacent tissue. The histological examination of the surgical specimen confirmed the DFSP diagnosis and determined safe microscopic margins. After 4 years of regular follow-up, no locoregional or distant recurrence was observed. We discuss through this case the diagnosis difficulties and the particularities of the abdominal wall localization.
Translating across kingdoms: target of rapamycin promotes protein synthesis through conserved and divergent pathways in plants
Authors: Scarpin M Regina , Simmons Carl H , Brunkard Jacob O 
Published: June 2022

Abstract
mRNA translation is the growth rate-limiting step in genome expression. Target of rapamycin (TOR) evolved a central regulatory role in eukaryotes as a signaling hub that monitors nutrient availability to maintain homeostasis and promote growth, largely by increasing the rate of translation initiation and protein synthesis. The dynamic pathways engaged by TOR to regulate translation remain debated even in well-studied yeast and mammalian models, however, despite decades of intense investigation. Recent studies have firmly established that TOR also regulates mRNA translation in plants through conserved mechanisms, such as the TOR–LARP1–5ʹTOP signaling axis, and through pathways specific to plants. Here, we review recent advances in our understanding of the regulation of mRNA translation in plants by TOR.
Pulsating B stars in the Scorpius–Centaurus Association with TESS
Authors: Sharma Awshesh N , Bedding Timothy R , Saio Hideyuki , White Timothy R 
Published: June 2022

ABSTRACT
We study 119 B stars located in the Scorpius–Centaurus Association using data from NASA’s TESS Mission. We see pulsations in 81 stars (68 per cent) across the full range of effective temperatures. In particular, we confirm previous reports of low-frequency pulsations in stars whose temperatures fall between the instability strips of SPB stars (slowly pulsating B stars) and δ Scuti stars. By taking the stellar densities into account, we conclude that these cannot be p modes and confirm previous suggestions that these are probably rapidly rotating SPB stars. We also confirm that they follow two period–luminosity relations that are consistent with prograde sectoral g modes that are dipole (l = m = 1) and quadrupole (l = m = 2), respectively. One of the stars (ξ2 Cen) is a hybrid pulsator that shows regular spacings in both g and p modes. We confirm that α Cru has low-amplitude p-mode pulsations, making it one of the brightest β Cephei stars in the sky. We also find several interesting binaries, including a very short-period heartbeat star (HD 132094), a previously unknown eclipsing binary (π Lup), and an eclipsing binary with high-amplitude tidally driven pulsations (HR 5846). The results clearly demonstrate the power of TESS for studying variability in stellar associations.
Quasi-randomization by survey date for policy analysis
Authors: Kim Kimin , Lee Myoung-Jae 
Published: June 2022

AbstractIn annual surveys, the interview dates are scattered over several months. When a policy takes place during the survey period, quasi-randomized data may be obtained, if individuals interviewed before and after the policy timing are similar. The policy effect can be found with a before–after difference, which is ‘Quasi-Randomization by Survey date (QRS)’. QRS may be viewed as an regression discontinuity (RD) with time as the running variable. When seasonality is present, the RD-style estimator fails, but we develop a difference-in-differences style estimator, which relies on a weaker assumption analogous to parallel trends that controls for sesonality. We provide an empirical example using Korea Labor and Income Panel Study data for a weekly work-hour reduction law in 2004 from 44 to 40 h. We find that the law effect is about 2 h reduction, not 4 h as the law stipulates.
Risk Factors for Admission Within a Hospital-Based COVID-19 Home Monitoring Program
Authors: Sperring Heather , Hofman Melissa , Hsu Heather E , Xiao Yian , Keohane Elizabeth A , Lodi Sara , Marathe Jai , Epstein Rachel L 
Published: June 2022

Abstract

Background
Despite increasing vaccination rates, coronavirus disease 2019 (COVID-19) continues to overwhelm heath systems worldwide. Few studies follow outpatients diagnosed with COVID-19 to understand risks for subsequent admissions. We sought to identify hospital admission risk factors in individuals with COVID-19 to guide outpatient follow-up and prioritization for novel therapeutics.

Methods
We prospectively designed data collection templates and remotely monitored patients after a COVID-19 diagnosis, then retrospectively analyzed data to identify risk factors for 30-day admission for those initially managed outpatient and for 30-day re-admissions for those monitored after an initial COVID-19 admission. We included all patients followed by our COVID-19 follow-up monitoring program from April 2020 to February 2021.

Results
Among 4070 individuals followed by the program, older age (adjusted odds ratio [aOR], 1.05; 95% CI, 1.03–1.06), multiple comorbidities (1–2: aOR, 5.88; 95% CI, 2.07–16.72; ≥3: aOR, 20.40; 95% CI, 7.23–57.54), presence of fever (aOR, 2.70; 95% CI, 1.65–4.42), respiratory symptoms (aOR, 2.46; 95% CI, 1.53–3.94), and gastrointestinal symptoms (aOR, 2.19; 95% CI, 1.53–3.94) at initial contact were associated with increased risk of COVID-19-related 30-day admission among those initially managed outpatient. Loss of taste/smell was associated with decreased admission risk (aOR, 0.46; 95% CI, 0.25–0.85). For postdischarge patients, older age was also associated with increased re-admission risk (aOR, 1.04; 95% CI, 1.01–1.06).

Conclusions
This study reveals that in addition to older age and specific comorbidities, the number of high-risk conditions, fever, respiratory symptoms, and gastrointestinal symptoms at diagnosis all increased odds of COVID-19-related admission. These data could enhance patient prioritization for early treatment interventions and ongoing surveillance.
Valorization of transdisciplinary research: An evaluation approach and empirical illustration
Authors: Munaretto Stefania , Mooren Caro E , Hessels Laurens K 
Published: June 2022

Abstract
In recent times, there has been a surge of impact-oriented, transdisciplinary research programmes and projects integrating multiple disciplines, types of knowledge and practices. An essential element often mentioned in the literature to improve the performance of these programmes and support impact delivery is continuous reflection and learning via evaluation. We argue that because a standard format for organizing transdisciplinary research does not exist, tailor-made evaluation approaches designed around the specificities of each programme are needed. The existing evaluation literature provides useful building blocks that can be integrated and adapted to specific transdisciplinary research contexts. In this article, we develop the valorization cycle and apply it to evaluate a transdisciplinary research programme in the water sector. The building blocks of our approach are: understanding of valorization as a cyclical process; theory of change as a logic model to structure the evaluation; productive interactions as a process indicator articulated in learning outcomes (cognitive, relational, and strategic); and impact pathways as narratives to explain impact dynamics. Our framework is based both on research evaluation and learning literature and on our personal experience in the evaluation of transdisciplinary research. The evaluation of the programme showed how the valorization cycle can point to different learning outcomes across the research process that are conducive to impact, and provided useful insights to the programme managers to adjust the programme. The principle of tailoring an evaluation approach to the specificities of the programme evaluated using building blocks from the literature will be applicable in other transdisciplinary contexts too.
Diaphragm pacing implantation in Japan for a patient with cervical spinal cord injury: A case report
Authors: Yokota Kazuya , Masuda Muneaki , Koga Ryuichiro , Uemura Masatoshi , Koga Tadashi , Nakashima Yasuharu , Kawano Osamu , Maeda Takeshi 
Published: June 2022

Rationale:
Traumatic cervical spinal cord injury (SCI) is a devastating condition leading to respiratory failure that requires permanent mechanical ventilation, which is the main driver of increased medical costs. There is a great demand for establishing therapeutic interventions to treat respiratory dysfunction following severe cervical SCI.

Patient concerns and diagnosis:
We present a 24-year-old man who sustained a cervical displaced C2–C3 fracture with SCI due to a traffic accident. As the patient presented with tetraplegia and difficulty in spontaneous breathing following injury, he was immediately intubated and placed on a ventilator with cervical external fixation by halo orthosis. The patient then underwent open reduction and posterior fusion of the cervical spine 3 weeks after injury. Although the patient showed significant motor recovery of the upper and lower limbs over time, only a slight improvement in lung capacity was observed.

Interventions and outcomes:
At 1.5 years after injury, a diaphragmatic pacing stimulator was surgically implanted to support the patient’s respiratory function. The mechanical ventilator support was successfully withdrawn from the patient 14 weeks after implantation. We observed that both the vital capacity and tidal volume of the patient were significantly promoted following implantation. The patient finally returned to daily life without any mechanical support.

Lessons:
The findings of this report suggest that diaphragmatic pacing implantation could be a promising treatment for improving respiratory function after severe cervical SCI. To our knowledge, this is the first SCI patient treated with a diaphragm pacing implantation covered by official medical insurance in Japan.
Tracheal neurofibroma treated by repeated flexible bronchoscopic cryotherapy: A case report
Authors: Yoo Ji Soo , Choe Yeong Hun , Lee Yong Chul , Kim So Ri 
Published: June 2022

Rationale:
Isolated endotracheal neurofibroma is very rare. The majority of neurofibromas are benign, but rarely, they can become cancerous. Furthermore, symptomatic neurofibroma is usually treated by surgical resection. Recently, several alternative options for surgical resection of this airway pathology have been suggested and developed, including bronchoscopic cryotherapy. Nevertheless, there has been no report on the application of repeated flexible bronchoscopic cryotherapy to remove an endotracheal neurofibroma.

Patient concerns:
A 65-year-old woman presented with progressive dyspnea and productive cough. Chest computed tomography scans revealed a 1.5-cm polypoid-shaped mass with fat attenuation and mild enhancement in the distal trachea. Flexible bronchoscopic cryotherapy was performed to remove the mass and confirm the diagnosis.

Diagnosis:
Pathologically, the mass was diagnosed as an endotracheal neurofibroma occupying the distal tracheal lumen.

Interventions:
The endotracheal neurofibroma was completely removed with repeated flexible bronchoscopic cryotherapy instead of surgical resection.

Outcomes:
Follow-up flexible bronchoscopy also revealed that there was no regrowth of the neurofibroma. Up to 18 months after the completion of serial cryotherapy, the patient had no recurrent symptoms or complaints.

Lessons:
Flexible bronchoscopic cryotherapy can be performed repeatedly for therapeutic purposes for airway tumors. It is recommended to consider flexible bronchoscopic cryotherapy as an alternative therapeutic option for patients with central airway obstruction due to tumorous lesions such as neurofibromas.
Interrelationship among thigh intermuscular adipose tissue, cross-sectional area, muscle strength, and functional mobility in older subjects
Authors: Borghi Stefano , Bonato Matteo , La Torre Antonio , Banfi Giuseppe , Vitale Jacopo Antonino 
Published: June 2022

The aim of this cross-sectional study was to investigate the association between lower limb strength, muscle mass and composition, and balance ability in elders.
Thirthy-four older participants (Age: 65.6 ± 4.73 years; male = 10 and female = 24) were assessed for muscle strength (maximal isometric strength of knee extensors and one repetition maximum by leg press, the one repetition maximum [1RM]), balance and gait capacity (Mini-BESTest), body composition by whole-body dual energy x-ray absorptiometry (obtaining Appendicular Skeletal Muscle Mass Index, ASMMI), and magnetic resonance imaging of thigh to evaluate Intermuscular Adipose Tissue (IMAT) and muscle Cross Sectional Area (CSA).
Positive correlations between 1RM and ASMMI (rs = 0.64, P < .0001) and thigh CSA (rs = 0.52, P = .0017), but not with thigh IMAT, were found. In addition, significant correlations between knee extensors strength and ASMMI (rs = 0.48, P = .004) and thigh CSA (rs = 0.49, P = .0033) and IMAT (rs = -0.35, P = .043) were observed, whereas no significant correlations between the Mini-BESTest with ASMMI, thigh CSA, and IMAT were observed.
Lower limb strength positively correlated with appendicular muscle mass. Further, the maximal isometric strength of knee extensors negatively correlated with thigh IMAT in elderly patients, whereas the dynamic balance ability did not correlate with any of the morphological variables of the muscle (i.e., ASMMI, CSA, and IMAT). A reduced muscle size and strength could affect movement and reduce physical function in older patients. Improving the composition and size of muscle in elder subjects could reduce frailty and risk of falls.
Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings
Authors: Bak Seongjun , Choi Hye Young , Lee Jeong-Hee , Na Jae Beom , Choi Dae Seob , Cho Jae Min , Choi Ho Cheol , Park Mi Jung , Kim Ji Eun , Shin Hwa Seon , Won Jung Ho , Kim Ju-Yeon , Kim Jae-Myung 
Published: June 2022

Rationale:
Mucoepidermoid carcinoma (MEC) of the breast is a rare entity, with an estimated incidence of only 0.2% to 0.3% of all primary breast tumors. The radiological features of breast MEC have scarcely been investigated mainly because of its rarity. In this article, we present a case of breast MEC diagnosed at our hospital and review the literature, focusing on radiological findings and radiologic–pathologic correlations that could improve clinical management of this entity. To the best of our knowledge, our study is the first review of the literature that focuses on the radiological features of breast MEC.

Patient concerns:
A 47-year-old premenopausal woman presented with a painless palpable mass in the right breast.

Diagnosis:
Mammography and ultrasonography revealed a mass with suspicious malignant features, which was categorized as Breast Imaging Reporting and Data System category 4c. A 14-gauge core-needle biopsy revealed an intermediate-grade MEC of the breast. The patient underwent breast magnetic resonance imaging and chest computed tomography for preoperative evaluation. Postoperative histopathological examination confirmed a diagnosis of intermediate-grade MEC. The clinical staging was T2N0M0.

Interventions:
The patient underwent breast-conserving surgery, adjuvant chemotherapy, radiotherapy, and hormonal therapy.

Outcomes:
No evidence of recurrence has been reported over 37 months.

Lessons:
The imaging characteristics of breast MEC were variable, and there were no specific radiological features for diagnosis. The presence of cystic components on radiological imaging is likely to be an indicator of a low-grade tumor and better prognosis, although the number of reported cases is limited.
Oral Lactobacillus fermentum CECT5716 in the patients with lactational abscess treated by needle aspiration: The late follow-up of a randomized controlled trial
Authors: Zhang Yi , Gao Yajun , He Xiangping , Ding Songtao , Gao Haifeng 
Published: June 2022

Background:
Lactational mastitis and breast abscess cause trouble for women. It has been shown that oral probiotics can improve breast microecology, thus alleviating inflammatory responses. Our study aims to understand the long-term effect of Lactobacillus fermentum CECT5716 on patients with lactational breast abscess after needle aspiration.

Methods:
Data continued in a randomized controlled study of 101 subjects with lactational abscess from 12 hospitals were included. They were randomly divided into an experimental group and a control group. After needle aspiration treatment, the experimental group was orally administrated with L fermentum CECT5716 for 4 consecutive weeks, while the control group was treated with maltodextrin in the same way). In the third month after randomized controlled trial, the subjects were followed up by an online questionnaire investigation. The observation indexes included the relief of breast pain, recurrence of mastitis from the end of oral administration to the follow-up, and the effect on continuing breastfeeding.

Results:
A total of 101 patients were enrolled and 83 valid questionnaires were received during follow-up, including 40 in the experimental group and 43 in the control group. The rate of stop breastfeeding due to recurrence of mastitis was 2.5% (1/40) in the experimental group and 18.6% (8/43) in the control group, with a statistically significant difference (odds ratio = 0.112, 95% confidence interval: 0.013–0.942, P < .05). The rate of stop breastfeeding was 10% (4/40) in the experimental group and 25.6% (11/43) in the control group, without significant difference. The pain relief rate in the experimental group was 80% (32/40), which showed no significant difference from that in the control group, that is, 72.1% (31/43). The recurrence rate of mastitis in the experimental group was 20% (8/40), which was not significantly different from that in the control group, that is, 16.3% (7/43).

Conclusions:
In lactating women with a history of breast abscess, oral L fermentum CECT5716 may reduce the risk of stop breastfeeding due to recurrence of mastitis.
Epidemiological and etiological characteristics of viral meningitis for hospitalized pediatric patients in Yunnan, China
Authors: Liu Hongbo , Zhang Haihao , Zhang Ming , Changzeng Feng , Cong Shanri , Xu Danhan , Sun Hao , Yang Zhaoqing , Ma Shaohui 
Published: June 2022

Background:
Viral infection is the most common cause of aseptic meningitis. The purpose of this study was to identify the viruses responsible for aseptic meningitis to better understand the clinical presentations of this disease.

Method:
Between March 2009 and February 2010, we collected 297 cerebrospinal fluid specimens from children with aseptic meningitis admitted to a pediatric hospital in Yunnan (China). Viruses were detected by using “in house” real-time quantitative polymerase chain reaction or reverse-transcription real-time quantitative polymerase chain reaction from these samples. Phylogenetic analyses were conducted using the Molecular Evolutionary Genetic Analysis version 7.0 software, with the neighbor-joining method.

Results:
Viral infection was diagnosed in 35 of the 297 children (11.8%). The causative viruses were identified to be enteroviruses in 25 cases (71.4%), varicella-zoster virus in 5 cases (14.3%), herpes simplex virus 1 in 2 cases (5.7%), and herpes simplex virus 2, Epstein–Barr virus, and human herpesvirus 6 in 1 case each (2.9% each). Of the enteroviruses, coxsackievirus B5 was the most frequently detected serotype (10/25 cases; 40.0%) and all coxsackievirus B5 strains belonged to C group.

Conclusions:
In the study, a causative virus was only found in the minority of cases, of them, enteroviruses were the most frequently detected viruses in patients with viral meningitis, followed by varicella-zoster virus and herpes simplex virus. Our findings underscore the need for enhanced surveillance and etiological study of aseptic meningitis.
Diffusion-weighted MR is useful to assess peripheral nerve invasion of soft tissue tumor
Authors: Wu Gang , Liu Liangjin , Mei Zou , Li Xiaoming 
Published: June 2022

To investigate the feasibility of readout-segmented diffusion-weighted (rsDW) magnetic resonance (MR) in assessing nerve invasion of soft tissue tumor. Forty-four patients with soft tissue mass in upper leg suspected of nerve invasion underwent rsDW MR. Nerve invasion by tumor was rated by 2 radiologists, respectively. Sensitivity and specificity of rsDW MR in identifying nerve invasion were calculated, with operation findings as reference of standard. Apparent diffusion coefficient and fraction of anisotropy of nerve were obtained using DW MR, and then were compared between invaded nerves and noninvasion cases. Inter-reader agreement in using rsDW MR to rate nerve invasion was excellent (kappa = 0.891 ± 0.043, P < 0.001). Sensitivity and specificity of rsDW MR in identifying nerve invasion were 89% and 88%, respectively. Apparent diffusion coefficient was significantly higher in invaded nerves versus normal nerves (1.45 ± 0.67 × 10−3 mm2/s vs 1.39 ± 0.46 × 10−3 mm2/s, P < 0.05). Fraction of anisotropy was significantly lower in invaded nerves versus normal nerves (0.22 ± 0.11 vs 0.37 ± 0.13, P < .05).
Readout-segmented DW MR was feasible in assessing sciatic nerve invasion by soft tissue tumor in selected patients.
Acute pancreatitis as a rare adverse event among cannabis users: A systematic review
Authors: Jaiswal Vikash , Mukherjee Dattatreya , Batra Nitya , Ruchika FNU , Susheela Ammu Thampi , Chia Jia Ee , Mukherjee Deblina , Naz Sidra , Victor Aguilera-Alvarez , Pokhrel Nishan Babu , Song David , Seen Tasur , Almas Talal , Saleh Mohanmad Abou , Bansrao Amandeep Singh , Mansoor Emad 
Published: June 2022

Background:
Cannabis use has been steadily rising in the United States and can have multiple adverse effects, including cannabis-induced acute pancreatitis. This study aims to collate and highlight the significant demographics, clinical presentation, and outcomes in patients with cannabis-induced acute pancreatitis.

Method:
A systematic literature search of electronic databases for peer-reviewed articles was conducted. After an initial search, we found 792 articles through different electronic databases. After manually removing duplicates and articles that did not meet the criteria, 25 articles were included in our review.

Results:
A total of 45 patients were studied, 35 (78%) cases were male and 10 (22%) cases were female, showing male predominance. The mean age of all participants was 29.2 ± 10.3 years. The most common presenting symptoms were abdominal pain 21 of 21 (100%), nausea 17 of 21 (81%), and vomiting 12 of 20 (60%). Ultrasound was normal in the majority of patients, with findings of mild pancreatitis. Computerized tomography scans revealed pancreatic edema and inflammation in 7 of 20 (35%) patients, and findings of necrotizing pancreatitis and complex fluid collection were visualized in 3 of 20 (15%) patients. Dilatation of intrahepatic or extrahepatic biliary ducts was not seen in any patients. The overall prognosis was good, with reported full recovery.

Conclusions:
Cannabis should be included in the differential diagnosis for the etiology of acute pancreatitis, which would help in early intervention and treatment for the mitigation of the rapidly progressive disease.