bluuebunny/crossref_metadata_2025_split huggingface dataset:
NJUST-CCTD: An Image Database for Milling Tool Wear Classification with Deep Learning
Authors: Pan Yi , Xu Guoda , Xiong Zhe , Li Fengjiao , Hu Bowen , Sun Yuxin , Pan Chunhong , Wang Yulin 
Published: August 2022

Abstract
Deep learning has gained popularity in the task of tool wear identification recently. As an important application of deep learning, however, there exist few public datasets and benchmarks for the research of visual identification of tool wear. To address this issue, we present a classification-based image dataset for carbide milling tool wear (NJUST-CCTD) and make it publicly available on the Github website. This dataset includes two categories: wear tools and no-wear tools. The two categories contain 5000 and 3000 photos, respectively. Based on this dataset, eight baselines are evaluated as references against this benchmark. To further improve the classification performance, we propose a novel cemented carbide milling tool wear intelligent classification framework (CMCNet). The framework consists of two modules: a deep learning based classification network and a multi-scale feature fusion denoising network called DSSNet. DSSNet is constructured with deeper network structure, connections across layers, and multi-scale sequence fusion module. It is capable of explicitly modeling the semantic and spatial correlation. Apart from DSSNet, the denoising module further improves the performance by adaptively altering the level of denoising based on the performance of the network. The two modules could be optimized with the backward gradient, yielding an end-to-end learning framework. On the basis of the dataset, CMCNet performed exceptionally well when categorizing photos intelligently. After 50 training epochs, the model outperformed the original classification network by 3.250%, achieving the top-1 accuracy of 95.375% on the test set. The NJUST-CCTD can be downloaded at https://github.com/paddy112233/PADDY
Gabapentin for treatment of neonatal abstinence syndrome in patients with or without perinatal gabapentin exposure
Authors: O'Mara Keliana , Edwards Laura 
Published: August 2022

Abstract
Objective
To determine the effect of gabapentin on neonatal abstinence syndrome (NAS)-related neurologic and/or feeding symptoms.
Study Design:
Retrospective case series involving thirteen infants who received gabapentin for NAS
Result
Gabapentin 5 mg/kg every 8 to 12 hours was initiated, and three (23%) patients required dose escalation. Median time from initiation to discharge was 8 days (range: 2–15) and length of stay was 19 days (range: 13–45 days). Eight patients required gavage feeds, and showed oral feeding improvement. All patients were discharged home with gabapentin and weaned off in the outpatient setting.
Conclusion
Although there is limited experience with gabapentin for NAS, it may be beneficial for managing symptoms not controlled by other treatment modalities, regardless of prenatal exposure. No side effects were noted and oral feeding was improved. Prospective randomized studies are needed to confirm the efficacy and safety of gabapentin in the treatment of neonatal abstinence syndrome.
Genomic diversity of β-lactamase producing Pseudomonas aeruginosa in Iran; the impact of global high-risk clones
Authors: Ahmadi Nazila , Salimizand Himen , Zomorodi Abolfazl Rafati , Abbas Jalileh Ebn , Ramazanzadeh Rashid , Haghi Fakhri , Hassanzadeh Sepideh , Jahantigh Mojdeh , Shahin Mojtaba 
Published: August 2022

Abstract
Background and aims: Hospital-acquired infections caused by multidrug-resistant Pseudomonas aeruginosa incline hospital stay and costs of treatment that resulted in an increased mortality rate. The frequency of P. aeruginosa high-risk clones producing carbapenemases was investigated in our clinical samples. Materials and Methods: In this cross-sectional study, 155 non-repetitive P. aeruginosa isolates were included from different medical centers of Iran. Antibiotic susceptibility testing was determined, and the presence of β-lactamases were sought by phenotypic and genotypic methods. The clonal relationship of all isolates was investigated, and multi-locus sequence typing (MLST) was used for finding the sequence types of carbapenemas-producers.Results: The most susceptibility rate was recorded for colistin (94.9%). MOX and FOX were found both as low as 1.95% (3/155). The most frequent ESBL was SHV with 7.7% (12/155) followed by PER, OXA-1, and TEM with the frequency of 7.1% (11/155), 3.2% (5/155), and 1.3% (2/155), respectively. Carbapenemases were detected in 28 isolates (18%). The most frequent carbapenemas was IMP with 9% (14/155) followed by NDM, 8.4% (13/155). OXA-48 and VIM were also detected both per one isolate (0.65%). MLST of carbapenem resistant P. aeruginosa isolates revealed that ST244, ST664, ST235, and ST357 were spread in subjected clinical settings. REP-PCR uncovered high genomic diversity in our clinical setting. Conclusion: Clonal proliferation of ST235 strain plays a key role in the propagation of MDR pattern in P. aeruginosa. Our data showed that high-risk clones has distributed in Iran, and programs are required to limit spreading of these clones.
Comparison of Two Analyzer Measurements Focusing on Material Stiffness Among Normal, Treatment-naïve, and Treated Glaucoma Eyes
Authors: Aoki Shuichiro , Asaoka Ryo , Fujino Yuri , Nakakura Shunsuke , Murata Hiroshi , Kiuchi Yoshiaki 
Published: August 2022

Abstract
Purpose: To investigate differences in biomechanical properties focusing on stiffness parameters between normal, treatment-naïve primary open-angle glaucoma (POAG), and treated POAG eyes.Design: Retrospective case-control studyMethods: This study included 46 treatment-naïve POAG eyes, 46 POAG eyes treated with prostaglandin analogues, and 49 normal eyes used as controls; matched in terms of age and axial length. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer (ORA). Fifteen biomechanical parameters were obtained with the Corneal Visualization Scheimpflug Technology (Corvis ST), including biomechanical glaucoma factor (BGF) and two stiffness parameters of ‘SP A1’ and ‘stress-strain index (SSI)’, which were compared among the three groups. Additionally, the area under the curve (AUC) values of the receiver-operating curve, to discriminate control and treatment-naïve POAG eyes were calculated and compared between CH and BGF.Results: Treatment-naïve POAG eyes had higher ‘SSI’ than normal eyes even after controlling for IOP (p<0.05, Tukey-Cramer test). Treated POAG eyes had significantly lower CRF, and higher BGF than treatment-naïve POAG eyes. There were insignificant differences in CH or SP A1 among the three groups. BGF and CH had no significantly different AUC values to discriminate between control and treatment-naïve POAG eyes (0.61 and 0.59).Conclusions: Treatment-naïve POAG eyes had stiffer corneas compared to normal eyes, which seemed to result from the material of the cornea rather than higher intraocular pressure. Antiglaucoma topical medication alters biomechanical properties measured with Corvis ST. These results are important for understanding the pathogenesis and improving the management of POAG.
Single-port laparoscopic hepatectomy: Slovenian single center experience
Authors: Jerica Novak , Blaž Trotovšek , Mihajlo Đokić 
Published: August 2022

Abstract
Background: Single-port laparoscopic hepatectomy is a minimally invasive modality for the treatment of the benign and malignant liver lesions. Due to the methods technical challenges it is suitable for experienced hepatobilliary surgeons in selected group of patients. The aim of this study was to evaluate the results of a single Slovenian centre performing single-port laparoscopic hepatectomy with literature overview.Methods: A single centre retrospective consecutive case series of the thirteen patients with liver disease operated with the single-port technique form January 2018 to April 2022 at the Department of the Abdominal Surgery in the University Medical Centre Ljubljana was performed. Lesions were located in the easy to treat segments. The operative time, conversion rate, length of the hospital stay and surgical complications were recorded and evaluated.Results: We performed thirteen single-port liver hepatectomies (median age 60, range 31 to 79 years). Mean operative time was 98 ± 37 min. None of the cases was converted to multi-port laparoscopic or open surgery. Safe resection margins were obtained in case of malignant disease. The mean hospital stay was 4 days. Post-operative complication involving intervention was 7% (1/13). No life-threatening surgical complication or morbidity were noted.Conclusions: The single-port laparoscopic hepatectomy is a safe and feasible technique for the operation of benign and malignant liver lesions in hands of skilled and well trained surgeons.
Application of viscoelastic agent or triamcinolone acetonide to prevent recurrent vitreous hemorrhage after vitrectomy for proliferative diabetic retinopathy with unabsorbed vitreous hemorrhage. A pilot study
Authors: Qiu Chang-yu , Shi Yuan-Yuan , Zhao Hong-Wei , Gong Yu-Bo , Nie Chuang , Wang Meng-Ge , Jia Rui , Zhao Jun , Wang Xin , Luo Ling 
Published: August 2022

Abstract
Background: To evaluate the possibilty of preventing recurrent vitreous hemorrhage (RVH) after vitrectomy in proliferative diabetic retinopathy (PDR) patients with unabsorbed vitreous hemorrhage (VH) by intravitreal injection of viscoelastic agent (VA) at the end of the surgery and compared its effect with triamcinolone acetonide (TA).Methods: This was a pilot prospective, observational study. PDR patients with VH who underwent vitrectomy were assigned to 3 groups according to the tamponade applicated at the end of the surgery, including VA group (intravitreal injected 1ml VA if the retina was prone to bleed during the operation), TA group (intravitreal injected 2mg TA when there was much exudates), or balanced salt solution (BSS) group (no tamponade). Then posteroperative follow-up was performed routinely until 6 months after surgery. The primary outcome was the incidence of RVH, secondary outcome were the best-corrected visual acuity (BCVA) and introcular pressure (IOP). Cataract formation and other complication were also assessed.Results: A total of 68 eyes, from 68 patients, were included. 18,18,32 eyes were enrolled in the VA group, TA group and BSS group, respectively. The integral incidence of RVH after PPV was 5.6%, 5.6% and 12.5% respectively (P= 0.602). There was no early RVH in VA or TA group, wheras 3 early RVHs was identified in BSS group, however there was no significant difference (P= 0.171). Every group had one late RVH case. In all groups, final BCVA showed significant improvement compared to baseline. BCVA at any postoperative visit showed no significant differences among 3 groups. Mean IOP was higher 1 week after surgey in VA group compared with the other groups; however, in other times the differences were not significant. No cataract formation and other complication was noted in 3 groups. Conclusion: Intravitreal injection of VA or TA at the end of vitrectomy for PDR patients with unabsorbed VH tend to reduce the incidence of early RVH after vitrectomy similarly. As VA was preferred to applicate in the eyes that were prone to bleed, intravitreal injection of VA at the end of vitrectomy might be a promising method for preventing RVH in PDR patients.
Coinfection of Monkeypox, COVID-19 and Syphilis in a PrEP using MSM: A case report from Barcelona.
Authors: Vives Alvaro , Vantman Doron , Rocco Maurizio , Muñoz Carlos A. , Alonso-Tarres Carles , Castañe Eduard Ruiz , Cosentino Marco 
Published: August 2022

Abstract

Monkeypox virus (MPXV) is a zoonotic disease, with endemic circulation and it’s not considered a sexually transmitted infection. Recently, it has been reported a particularly high incidence among men who have sex with men (MSM). We report the first case of a male HIV-negative patient with HIV Pre-Exposition Prophylaxis (PrEP), and a simultaneous coinfection of Monkeypox Virus, Covid19 and Syphilis.
Novel role of AMPK in cocaine reinforcement via regulating CRTC1
Authors: Han Ying , Liu Xiaoxing , Liu Fanglin , Li Xin , Lu Tangsheng , Luo Yixiao , Jian Min , Yuan Kai , Meng Shi-Qiu , Bao Yanping , Shi Jie , Lu Lin 
Published: August 2022

AbstractRepeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs. Previous studies suggested a role for adenosine monophosphate-activated protein kinase (AMPK), a cellular energy sensor, in modulating neuronal morphology and membrane excitability. However, the potential involvement of AMPK in cocaine addiction is still unclear. The present study employed a cocaine self-administration model in rats to investigate the effect of AMPK and its target cyclic adenosine monophosphate response element binding protein-regulated transcriptional co-activator 1 (CRTC1) on cocaine reinforcement and the motivation for cocaine. We found that intravenous cocaine self-administration significantly decreased AMPK activity in the NAc shell (NAcsh), which persisted for at least 7 days of withdrawal. Cocaine reinforcement, reflected by self-administration behavior, was significantly prevented or enhanced by augmenting or suppressing AMPK activity pharmacologically and genetically, respectively. Cocaine-induced increases in dendritic spine density in the NAcsh were attenuated by AMPK inhibition. No difference in sucrose self-administration behavior was found after the same manipulations. The inhibition of AMPK activity in the NAcsh also increased the motivation for cocaine in progressive-ratio schedules of reinforcement, whereas the activation of AMPK had no effect. The knockdown of CRTC1 in the NAcsh significantly impaired cocaine reinforcement, which was rescued by pharmacologically increasing AMPK activity. Altogether, these results indicate that AMPK is critical for morphological plasticity in the NAcsh and cocaine reinforcement, possibly via the regulation of CRTC1 signaling. These findings may help reveal potential therapeutic targets and have important implications for the treatment of cocaine addiction and relapse.
The effects of hard turning and deep rolling on surface integrity and fatigue life of deep groove ball bearings
Authors: Sağır Gökhan , Çiçek Adem , Müştak Ozan 
Published: August 2022

Abstract
This experimental study consists of two main steps. In the first step, the effects of cutting conditions and tool geometry on cutting forces, roundness error and surface integrity (surface roughness, residual stresses, and subsurface phase transformations) were studied on 6208-type deep groove ball bearings. In the second step, performances of grinding (GR), hard turning (HT) and hard turning + deep rolling (DR) applied to the inner ring raceways are compared to each other in terms of surface roughness, roundness error, residual stresses, noise level and fatigue life. Experimental results in the first step showed that lower surface roughness, roundness error and higher compressive stresses are achieved by V-35 cutting insert. A remarkable result in the second step is that although DR process produces higher compressive stresses in deeper layers of work surface, the bearings possess lower fatigue life than HT and GR bearings due to their higher roundness error values.
Bioenergy recovery from food waste through dark fermentation direction
Authors: Akhbari Azam , Ibrahim Shaliza 
Published: August 2022

Abstract
The increase in food waste generation has encouraged the scientific community to convert it into value-added resources. Hydrogen energy provides a sustainable option to fossil fuels due to its purity, high energy content, and reduction of global warming. This study investigates the batch fermentative biohydrogen production from food waste, which takes into account the effects on the process stability and energy recovery. Experiments were carried out at different ranges of pH (5.5, 6.0, and 6.5), FW concentration (1, 5, 10, 15, 20, 25, and 30 g-VS/L) at mesophilic (37˚C) and thermophilic (55˚C) temperature through 24h incubation of batch dark fermentation process. The FW concentration of 15–20 g-VS.L− 1 was found to be the proper concentration for biohydrogen production at 55˚C fermentation with the highest yield of 80.41 ml-H2/g-VS.L− 1, hydrogen content of 76.53%, at pH 6.0. Under mesophilic temperature, a lower hydrogen yield of 49.36 ml-H2/g-VS.L− 1and hydrogen content of 60.53% was produced in the same substrate concentration and pH. The COD removal efficiencies at 37 ˚C and 55 ˚C increased from 16.66–21.87%, and 20.83–29.09% at pH 6.0 with an increase in FW concentration from 1 to 20 g-VS.L− 1. Further increase in FW concentration showed less yield of hydrogen production. From pyrosequencing analysis, hydrogen fermentation at both temperatures was attributed to Lactobacillus and Clostridium sensu stricto 1, which confirms the potential of the microbial community for biohydrogen production.
Effects of core stability and feedback music on upper body mediolateral movements during cycling
Authors: Jeong Siwoo , Kim Si-Hyun , Park Kyue-Nam 
Published: August 2022

AbstractAsymmetry in involuntary trunk motion may be related to core stability. If core stability properly controls postural stability during distal segment movements, trunk motion should be symmetric. Based on the assumption that head motion partially represents trunk motion, we developed a system that measures head angle and provides feedback music on head motion. If the head angle exceeds a predefined threshold, the music is muted in the earbud on the side of the head tilt. To investigate the relationship between core stability and asymmetric trunk motion, we measured mediolateral head angles during cycling using a self-developed system and compared them between individuals with good and poor core stability, and we investigated the effects of feedback music on mediolateral head motion during cycling. The poor-core-stability group showed significantly greater amplitude of, and less symmetry in, mediolateral head motion than the good-core-stability group. Furthermore, feedback music significantly reduced the amplitude of mediolateral head motion in the good- and poor-core-stability groups and improved symmetry in mediolateral head motion in the poor-core-stability group. Our findings imply that core stability is important for maintaining symmetry in head motion during cycling. Feedback music could be useful for establishing symmetry in head motion during cycling.
Evaluating the First University-Based Online Graduate Course on Telemental Health in the Middle East: Lessons Learned from Lebanon
Authors: Naal Hady , Whaibeh Emile , Mrad Myriam 
Published: August 2022

Abstract

Background: Despite the increasing interest in mental health and shift of many clinicians to using telemental health (TMH) services following the COVID-19 pandemic, university-based educational opportunities covering TMH remain scarce in multiple regions of the world including Lebanon. Through a mixed-methods design, we evaluated the first implementation of a university-based online graduate course on TMH in Lebanon. Data was collected from students of different disciplines during class time and were triangulated and synthesized.Results: Despite this being an online course, high engagement and low absenteeissm was observed with students who remained interested in the topic. In-class interactive activities, limited theoretical pedagogical approaches, participation of international guest speakers, and contextualized material were all listed as key factors to the success of the course. Additionally, students demonstrated much critical thinking when asked about potential applicability of TMH in Lebanon during and after the course.Conclusions: Our experience demonstrates that online learning for TMH in Lebanon can be highly engaging for students depending on certain key factors that should be considered in the design and implementation of the course. This course may have potential to be replicated in other settings across the Middle East in this format to improve knowledge and confidence in TMH in other settings. Recommendations for future studies and similar implementations are discussed in the manuscript.
Changes in Cytokine and Cytokine Receptor Levels During Postnatal Development of the Human Dorsolateral Prefrontal Cortex
Authors: Sager Rachel E.H. , Walker Adam K. , Middleton Frank , Robinson Kate , Webster Maree J. , Gentile Karen , Wong Ma-Li , Weickert Cynthia Shannon 
Published: August 2022

Abstract
In addition to their traditional roles in immune cell communication, cytokines regulate brain development. Cytokines are known to influence neural cell generation, differentiation, maturation, and survival. However, most work on the role of cytokines in brain development investigates rodents or focuses on prenatal events. Here, we investigate how mRNA and protein levels of key cytokines and cytokine receptors change during postnatal development in the human prefrontal cortex. We find that most cytokine transcripts investigated (IL1B, IL18, IL6, TNF, IL13) are lowest at birth and increase between 2–5 years old. After 5 years old, transcriptional patterns proceeded in one of two directions: decreased expression in teens and young adults (IL1B, p = 0.002; and IL18, p = 0.004) or increased mean expression with maturation, particularly in teenagers (IL6, p = 0.004; TNF, p = 0.002; IL13, p < 0.001). In contrast, cytokine proteins tended to remain elevated after peaking significantly at age 5 (IL1B, p = 0.012; IL18, p = 0.026; IL6, p = 0.039; TNF, p < 0.001), with TNF protein being highest in young adults. Early developmental increases in cytokines were paralleled by increases in their receptor binding subunits, such as IL1R1 (p = 0.033) and IL6R (p < 0.001) transcripts. In contrast, cytokine receptor-associated signaling subunits, IL1RAP and IL6ST, did not change significantly between age groups. Of the two TNF receptors, the ‘pro-death’ TNFRSF1A and ‘pro-survival’ TNFRSF1B, only TNFRSF1B was significantly changed (p = 0.028), increasing first in toddlers and again in young adults. Finally, the cytokine inhibitor, IL13, was elevated first in toddlers (p < 0.001) and again in teenagers (p < 0.001). While the mean expression of interleukin-1 receptor antagonist (IL1RN) was highest in toddlers, this increase was not statistically significant. The fluctuations in cytokine expression reported here support a role for increases in specific cytokines at two different stages of human cortical development. The first is during the toddler/preschool period (IL1B and IL18) and the other at adolescence/young adult maturation (IL6 and TNF).