bluuebunny/crossref_metadata_2025_split huggingface dataset:
The contribution of landscape features, climate and topography in shaping taxonomical and functional diversity of avian communities in a heterogeneous Alpine region
Authors: Anderle Matteo , Paniccia Chiara , Brambilla Mattia , Hilpold Andreas , Volani Stefania , Tasser Erich , Seeber Julia , Tappeiner Ulrike 
Published: February 2022

AbstractUnderstanding the effects of landscape composition and configuration, climate, and topography on bird diversity is necessary to identify distribution drivers, potential impacts of land use changes, and future conservation strategies. We surveyed bird communities in a study area located in the Central Alps (Autonomous Province of South Tyrol, northeast Italy), by means of point counts and investigated taxonomic and functional diversity at two spatial scales along gradients of land use/land cover (LULC) intensity and elevation. We also explored how environmental variables influence bird traits and red-list categories. Models combining drivers of different types were highly supported, pointing towards synergetic effects of different types of environmental variables on bird communities. The model containing only LULC compositional variables was the most supported one among the single-group models: LULC composition plays a crucial role in shaping local biodiversity and hence bird communities, even across broad landscape gradients. Particularly relevant were wetlands, open habitats, agricultural mosaics made up of small habitat patches and settlements, ecotonal and structural elements in agricultural settings, and continuous forests. To conserve bird diversity in the Alps, planning and management practices promoting and maintaining small fields, structural elements, and a mosaic of different LULC types should be supported, while preserving continuous forests at the same time. Additionally, pastures, extensively used meadows, and wetlands are key to conservation. These strategies might mitigate the impacts of global change on bird diversity in the Alps and in other European mountain areas.
Comparison of health-care utilization and expenditures for minimally invasive vs. open colectomy for benign disease
Authors: Diaz Sarah E. , Lee Yongjin F. , Bastawrous Amir L. , Shih I.-Fan , Lee Shih-Hao , Li Yanli , Cleary Robert K. 
Published: February 2022

Abstract
Background
Adoption of minimally invasive approaches continues to increase, and there is a need to reassess outcomes and cost. We aimed to compare open versus minimally invasive colectomy short- and long-term health-care utilization and payer/patient expenditures for benign disease.

Methods
This is a retrospective analysis of IBM® MarketScan® Database patients who underwent left or right colectomy for benign disease between 2013 and 2018. Outcomes included total health-care expenditures, resource utilization, and direct workdays lost up to 365 days following colectomy. The open surgical approach (OS) was compared to minimally invasive colectomy (MIS) with subgroup analysis of laparoscopic (LS) and robotic (RS) approaches using inverse probability of treatment weighting.

Results
Of 10,439 patients, 2531 (24.3%) had open, 6826 (65.4%) had laparoscopic, and 1082 (10.3%) had robotic colectomy. MIS patients had shorter length of stay (LOS; mean difference, − 1.71, p < 0.001) and lower average total expenditures (mean difference, − $2378, p < 0.001) compared with open patients during the index hospitalization. At 1 year, MIS patients had lower readmission rates, and fewer mean emergency and outpatient department visits than open patients, translating into additional savings of $5759 and 2.22 fewer days missed from work for health-care visits over the 365-day post-discharge period. Within MIS, RS patients had shorter LOS (mean difference, − 0.60, p < 0.001) and lower conversion-to-open rates (odds ratio, 0.31 p < 0.001) during the index hospitalization, and lower hospital outpatient visits (mean difference, − 0.31, p = 0.001) at 365 days than LS.

Conclusion
MIS colectomy is associated with lower mean health-care expenditures and less resource utilization compared to the open approach for benign disease at index operation and 365-days post-discharge. Health-care expenditures for LS and RS are similar but shorter mean LOS and lower conversion-to-open surgery rates were observed at index operation for the RS approach.
Comparison of long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated-type early gastric cancer meeting the expanded criteria: a systematic review and meta-analysis
Authors: Yang Hyo-Joon , Kim Jie-Hyun , Kim Na Won , Choi Il Ju 
Published: February 2022

Abstract
Background
There have been concerns over the long-term outcomes of endoscopic submucosal dissection (ESD) for undifferentiated-type early gastric cancer (UD EGC). We aimed to compare the long-term outcomes of ESD and surgery for patients with UD EGC.

Methods
We searched PubMed, Embase, and Cochrane Library databases through March 2021 to identify studies that compared the long-term outcomes of ESD and surgery for UD EGC meeting expanded criteria for curative resection. The risk of bias was assessed with the Cochrane tool for non-randomized studies. The risk ratio (RR) was estimated using a fixed-effect model.

Results
Overall, 1863 patients from five retrospective cohort studies, including 908 patients with propensity score matching (PSM), were eligible for meta-analysis. ESD was associated with inferior overall survival (OS) compared to surgery in the overall cohort (RR 2.11; 95% CI 1.26–3.55) but not in the PSM cohort (RR 1.18; 95% CI 0.60–2.32). In the PSM cohort, ESD had a lower disease-free survival (DFS) (RR 2.49; 95% CI 1.42–4.35) and higher recurrence (RR 12.61; 95% CI 3.43–46.37), gastric recurrence (RR 11.25; 95% CI 3.06–41.40), and extragastric recurrence (RR 4.23; 95% CI 0.47–37.93). Recurrence outcomes were similar between the overall and PSM cohorts. Disease-specific survival was not significantly different between the two groups in both the overall and PSM cohorts.

Conclusion
Although OS after curative ESD for UD EGC was not different from that after surgery in the PSM cohort, DFS and recurrence were inferior after ESD. Limitations included a lack of randomized trials. Further prospective studies comparing the long-term outcomes of ESD and surgery for UD EGC are needed (PROSPERO CRD 42021237097).
Effectiveness of the Tailored, Early Comprehensive Rehabilitation Program (t-ECRP) based on ERAS in improving the physical function recovery for patients following minimally invasive esophagectomy: a prospective randomized controlled trial
Authors: Yang Funa , Li Lijuan , Mi Yanzhi , Zou Limin , Chu Xiaofei , Sun Aiying , Sun Haibo , Liu Xianben , Xu Xiaoxia 
Published: February 2022

AbstractBackgroundPerioperative rehabilitation management is essential to enhanced recovery after surgery (ERAS). Limited reports, however, have focused on quantitative, detailed early activity plans for patients receiving minimally invasive esophagectomy (MIE). The purpose of this research was to estimate the effectiveness of the Tailored, Early Comprehensive Rehabilitation Program (t-ECRP) based on ERAS in the recovery of bowel and physical functions for patients undergoing MIE.MethodsIn this single-blind, 2-arm, parallel-group, randomized pilot clinical trial, patients admitted to the Affiliated Cancer Hospital of Zhengzhou University from June 2019 to February 2020 were selected and randomly assigned to an intervention group (IG) or a control group (CG). The participants in the IG received medical care based on the t-ECRP strategy during perioperative period, and participants in the CG received routine care. The recovery of bowel and physical functions, readiness for hospital discharge (RHD), and postoperative hospital stay were evaluated on the day of discharge.ResultsTwo hundred and fifteen cases with esophageal cancer (EC) were enrolled and randomized to the IG (n = 107) or CG (n = 108). The mean age was 62.58 years (SD 9.07) and 71.16% were male. For EC, 53.49% were mid-location cancers and 79.07% were classified as pathological stage II and III cancers. There were no significant differences between the two groups in terms of demographic and clinical characteristics and baseline physical functions. Participants in the IG group presented significantly shorter lengths of time to first flatus (P < 0.001), first postoperative bowel movement (P = 0.024), and for up and go test (P < 0.001), and lower scores of frailty (P < 0.001). The analysis also showed that participants in the IG had higher scores of RHD and shorter lengths of postoperative stay than in the CG (P < 0.05).ConclusionsThe t-ECRP appears to improve bowel and physical function recovery, ameliorate RHD, and shorten postoperative hospital stay for patients undergoing MIE. Clinicians should consider prescribing quantitative, detailed, and individualized early activity plans for these patients.Trial registrationClinicalTrials.gov (Identifier: NCT01998230)
Amendment of the Japanese consensus guidelines for autoimmune pancreatitis, 2020
Authors: Okazaki Kazuichi , Kawa Shigeyuki , Kamisawa Terumi , Ikeura Tsukasa , Itoi Takao , Ito Tetsuhide , Inui Kazuo , Irisawa Atsushi , Uchida Kazushige , Ohara Hirotaka , Kubota Kensuke , Kodama Yuzo , Shimizu Kyoko , Tonozuka Ryosuke , Nakazawa Takahiro , Nishino Takayoshi , Notohara Kenji , Fujinaga Yasunari , Masamune Atsushi , Yamamoto Hiroshi , Watanabe Takayuki , Nishiyama Toshimasa , Kawano Mitsuhiro , Shiratori Keiko , Shimosegawa Tooru , Takeyama Yoshifumi ,   Members of the Research Committee for IgG4-related Disease supported by the Ministry of Health, Labour, Welfare of Japan, Japan Pancreas Society
Published: February 2022

AbstractIn response to the latest knowledge and the amendment of the Japanese diagnostic criteria for autoimmune pancreatitis (AIP) in 2018, the Japanese consensus guidelines for managing AIP in 2013 were required to be revised. Three committees [the professional committee for developing clinical questions (CQs) and statements by Japanese specialists; the expert panelist committee for rating statements by the modified Delphi method; and the evaluating committee of moderators] were organized. Twenty specialists in AIP extracted the specific clinical statements from a total of 5218 articles (1963–2019) from a search in PubMed and the Cochrane Library. The professional committee made 14, 9, 5, and 11 CQs and statements for the current concept and diagnosis, extra-pancreatic lesions, differential diagnosis, and treatment, respectively. The expert panelists regarded the statements as valid after a two-round modified Delphi approach with individually rating these clinical statements, in which a clinical statement receiving a median score greater than 7 on a 9-point scale from the panel was regarded as valid. After evaluation by the moderators, the amendment of the Japanese consensus guidelines for AIP has been proposed in 2020.
Synthesis of N4-acetylated 3-methylcytidine phosphoramidites for RNA solid-phase synthesis
Authors: Moreno Sarah , Flemmich Laurin , Micura Ronald 
Published: February 2022

AbstractThe growing interest in 3-methylcytidine (m3C) originates from the recent discoveries of m3C modified tRNAs in humans as well as its intensively debated occurrence in mRNA. Moreover, m3C formation can be catalyzed by RNA without the assistance of proteins as has been demonstrated for a naturally occurring riboswitch fold using the methylated form of its cognate ligand as cofactor. Additionally, new RNA sequencing methods have been developed to detect this modification in transcriptome-wide manner. For all these reasons, an increasing demand for synthetic m3C containing oligoribonucleotides is emerging. Their chemical synthesis relies on RNA solid-phase synthesis using phosphoramidite building blocks. Here, we describe a facile synthetic path towards N4-acetylated 2′-O-TBDMS- and 2′-O-TOM m3C phosphoramidites to provide an optimal toolbox for solid-phase synthesis of m3C containing RNA.
Graphical abstract
Longitudinal effects of emotion awareness and regulation on mental health symptoms in adolescents with and without hearing loss
Authors: Eichengreen Adva , Broekhof Evelien , Tsou Yung-Ting , Rieffe Carolien 
Published: February 2022

AbstractEmotion awareness (EA) and regulation (ER) are each known to associate with mental health symptoms, yet there is a paucity of longitudinal studies examining them jointly during adolescence. Furthermore, little is known about these skills and their relations in deaf and hard-of-hearing (DHH) adolescents, who are at risk for reduced emotion socialization and for more mental health symptoms. This longitudinal study examined the development and unique contributions of EA (emotion differentiation, emotion communication and bodily unawareness) and ER (approach, avoidance and worry/rumination) to internalizing and externalizing symptoms in adolescents with and without hearing loss. Using self- and parent's reports, we assessed 307 adolescents (age 9–15) three times over 18-month period. We found stability over time in development of EA and avoidance ER, increase in approach ER and decrease in worry/rumination. High levels and increases over time in two aspects of EA, emotion differentiation and communication, and in approach and avoidance ER were related to decreases in depressive symptoms. An increase in approach ER was also related to a decrease in anxiety symptoms. Yet, low levels or decreases in worry/rumination were related to decreased levels of depressive, anxiety and externalizing symptoms. Hearing loss did not moderate any of the variables or relations tested. Preliminary tests suggested heterogeneity within the DHH group according to educational placement, language abilities and parental education level. Overall, findings pointed at unique contributions of EA and ER to mental health development, suggesting that DHH adolescents, especially in mainstream schools, do not differ from their hearing peers in their emotion awareness and regulation.
Stakeholders’ perceptions of factors influencing climate change risk in a Central America hotspot
Authors: Feliciano Diana , Sobenes Alejandra 
Published: February 2022

AbstractTo identify adaptation priorities, countries aim to systematically assess their climate change risks, consistent with international agreements. National-scale risk assessment usually follows an expert-led procedure that aims to establish traction with existing policy processes. This may underrepresent important local or regional contexts, including where there are divergent socio-cultural factors or value systems that influence risk perception. These differences in interpretation are explored in detail for Guatemala, located in a climate change risk “hotspot” region, based upon semi-structured interviews with a wide range of stakeholders. Perceptions of factors affecting climate change risk are assessed between different types of stakeholders. Adaptive capacity and risk governance are considered, including the role of international aid to reduce climate change risk in developing countries. Non-profit, inter-municipal organisations of two or more municipalities, namedmancomunidades, are potentially a useful structure to build adaptive capacity through reflexive risk assessment.
Fluoroless left atrial access for radiofrequency and cryoballoon ablations using a novel radiofrequency transseptal wire
Authors: Demo Hany , Aranda Carla , Razminia Mansour 
Published: February 2022

Abstract
Purpose
Conventional catheter ablation for atrial fibrillation requires fluoroscopy, which has inherent risks of radiation exposure to patients and medical staff. Optimization of fluoroscopy parameters and use of three-dimensional electroanatomic mapping (EAM) and intracardiac echocardiography (ICE) have helped to reduce radiation exposure; however, despite growing evidence, there are still concerns about safety and added procedure time associated with fluoroless procedures, particularly in left-sided ablations, due to the potential risk of complications. Herein, we report our initial experience using a radiofrequency (RF) wire for completely fluoroless radiofrequency ablation (RFA) and cryoballoon ablation (CBA).

Methods
A retrospective analysis was conducted on ablation procedures for various cardiac arrhythmias performed non-fluoroscopically at two centers using the VersaCross RF wire transseptal system under EAM and ICE guidance.

Results
A total of 72 and 54 patients underwent RFA and CBA, respectively, successfully without any procedural complications. Transseptal access time for RFA was 14.5 ± 6.6 min from procedure start (including sheath and catheter placements ± right-sided ablation) or 2.8 ± 1.0 min from RF wire insertion into the femoral introducer. Transseptal access time for CBA was 19.2 ± 11.7 min from procedure start (including sheath and catheter placements ± right-sided ablation) or 3.5 ± 1.6 min from RF wire insertion into the femoral introducer. Average procedure time was 104.4 ± 38.0 min for RFA and 91.1 ± 22.1 min for CBA.

Conclusions
A RF wire can be used to achieve completely fluoroless transseptal puncture safely and effectively while improving procedural efficiency in both RFA and CBA.
Substituting Silver for Tellurium in Selenium–Tellurium Thin Films for Improving the Optical Characteristics
Authors: Abd-Elnaiem Alaa M. , Abdelraheem A. M. , Abdel-Rahim M. A. , Moustafa Samar 
Published: February 2022

AbstractThe effect of Ag content on the linear and nonlinear optical characteristics of thermal evaporated Se90−xTe10Agx thin films, 100 nm thick, (where x = 0, 2, 4, 6, and 8 at.%) has been examined. The optical measurements were reviewed in the wavelength range of 390–2500 nm based on the transmittance and reflectance data, and the amorphous state of the as-prepared thin film was confirmed by X-ray diffraction. The absorption coefficient, extinction coefficient, bandgap, optical density, optical conductivity, dissipation factor, and other optical properties were examined and discussed. For all of the samples, the extinction coefficient of Se90−xTe10Agx declines as the wavelength and Ag concentration rise, whereas the absorption coefficient increases linearly with incident photon energy. Furthermore, the optical bandgap and the width of localized states alter in the exact opposite direction, which is consistent with previously reported findings. The decrease in the optical band gap as Ag concentration increases could be attributable to an increase in the amount of disorder in the materials and the density of defect states. Other critical optoelectronic characteristics are also determined, and they are found to be influenced by the Ag ratio and photon wavelength. These materials may be ideal for optical memory applications due to their high absorption coefficient and compositional dependence of absorption.
Oil crystallization properties as an index for monitoring early stage curing of oil-based paints: DSC analysis on linseed oil systems
Authors: Pizzimenti Silvia , Saitta Francesca , Signorelli Marco , Tinè Maria Rosaria , Bonaduce Ilaria , Duce Celia , Fessas Dimitrios 
Published: February 2022

AbstractIn this work, we propose to follow the crystallization capability of oils in oil-based paints, during curing, as an indirect index of the matrix status in the early stages of paint film formation that usually are indicative and crucial to understand the process evolution. To proof the concept, the oil crystallization properties were investigated through DSC measurements on samples of both unpigmented linseed oil and two model paints, composed by lead white + linseed oil (LWLO) and ultramarine blue + linseed oil (UBLO), at different ageing time at room and oxygen-limiting conditions. The results indicate that the curing process strongly affects the oil’s ability of forming crystals in the paint layers, and the proposed experimental approach is rather suitable and sensitive enough to discriminate differences between the action of pigments and environmental conditions. On the other hand, despite the simplicity and the potentiality, this approach is limited at the early stages of paint curing offering an index of the overall matrix status and therefore must be intended as a complementary method that has to be integrated with other approaches if the aim is to explore in detail the chemical and physical aspects of the curing process.
Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy
Authors: Essawy Amina E. , El-Sayed Soad Ahmed , Tousson Ehab , Abd El-gawad Horeya S. , Alhasani Reem Hasaballah , Abd Elkader Heba-Tallah Abd Elrahim 
Published: February 2022

AbstractEpilepsy is one of the most common serious brain disorders, affecting about 1% of the population all over the world.Ginkgo bilobaextract (GbE) and L-carnitine (LC) reportedly possess the antioxidative activity and neuroprotective potential. In this report, we investigated the possible protective and therapeutic effects of GbE and LC against pentylenetetrazol (PTZ)-induced epileptic seizures in rat hippocampus and hypothalamus. Adult male albino rats were equally divided into eight groups: control, GbE (100 mg/kg), LC (300 mg/kg), PTZ (40 mg/kg), protective groups (GbE + PTZ and LC + PTZ), and therapeutic groups (PTZ + GbE and PTZ + LC). The oxidative stress, antioxidant, and neurochemical parameters, viz., malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), acetylcholine esterase (AchE), dopamine (DA), norepinephrine (NE), and serotonin (5-HT), in the hippocampal and hypothalamic regions have been evaluated. PTZ injection leads to an increase in the seizure score, the levels of MDA and NO, and to a decrease in the activity of GSH, SOD, CAT, and GPx. Besides, monoamine neurotransmitters, DA, NE, and 5-HT, were depleted in PTZ-kindled rats. Furthermore, PTZ administration caused a significant elevation in the activity of AchE. Hippocampal and hypothalamic sections from PTZ-treated animals were characterized by severe histopathological alterations and, intensely, increased the ezrin immunolabeled astrocytes. Pre- and post-treatment of PTZ rats with GbE and LC suppressed the kindling acquisition process and remarkably alleviated all the aforementioned PTZ-induced effects. GbE and LC have potent protective and therapeutic effects against PTZ-induced kindling seizures via the amelioration of oxidative/antioxidative imbalance, neuromodulatory, and antiepileptic actions.
Adolescents’ Continuum and Categorical Beliefs, Help-seeking Intentions, and Stigma Towards People Experiencing Depression or Schizophrenia
Authors: Fernandez Dominic K. , Deane Frank P. , Vella Stewart A. 
Published: February 2022

AbstractThe present study investigated the relationships between continuum and categorical beliefs, stigma, and help-seeking in response to vignettes depicting depression and schizophrenia. Participants were 193 adolescents aged 13-18 years. Results showed no relationships between continuum beliefs and stigma or help-seeking intentions for the depression vignette when controlling for other predictors. Stronger categorical beliefs were associated with greater social distance, and endorsement of dangerousness, avoidance, and fear. For the schizophrenia vignette, higher continuum beliefs predicted lower prognostic pessimism, social distance, and stigmatising attitudes. Surprisingly, continuum beliefs predicted greater intentions to not seek help. Categorical beliefs were associated with greater prognostic pessimism, social distance, and stigmatising attitudes. Future research is needed to explore the effect of continuum belief interventions on adolescent mental health stigma.