bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are technology‐based health education methods able to reduce oral health inequalities between the sexes in adolescents? A cluster randomized trial
Authors: Marchetti Gisele , Vendruscolo Joana Leticia , Reis Giselle Emilãine da Silva , Fraiz Fabian Calixto , Soares Geisla Mary Silva , Assunção Luciana Reichert da Silva 
Published: October 2022

AbstractPurposeDetermine if different technology‐based health education interventions can reduce oral health inequalities between the sexes in a sample of adolescents.MethodsA cluster randomized clinical trial was conducted in three phases with an initial sample of 291 male and female adolescents 14–19 years of age. Phase I (n = 288) comprised a clinical examination performed by a calibrated examiner using the simplified oral hygiene index (OHI‐S) and gingival bleeding index (GBI). Phase II involved two educational interventions: video (VD; n = 147) or oral counselling (OR; n = 141) with standardized content. In phase III, an App was made available to half of the clusters (OR + App; n = 66/OR without App; n = 71/VD + App; n = 63/VD without App; n = 63), and the clinical examination was performed a second time. Data were evaluated using descriptive analysis and nonparametric tests.ResultsIn phase I, boys had a lower standard of oral hygiene compared with girls, with higher mean OHI‐S (p = 0.039) and GBI (p = 0.015). After VD and OR interventions, no significant difference between sexes was found regarding the mean OHI‐S. However, males had a higher mean GBI compared with females in the OR group (p = 0.006). When the App was added to OR and VD groups, males in the ‘OR without App’ group had a higher mean GBI compared with females (p = 0.007).ConclusionThis clinical trial demonstrated that educational interventions involving information technologies were effective at reducing oral health inequalities between the sexes among adolescents. However, oral counselling alone was not efficient in reducing GBI in male adolescents.
Cutaneous adverse drug eruption: the role of drug patch testing
Authors: Thaiwat Supitchaya , Rojanapanthu Pattareewan 
Published: October 2022

AbstractBackgroundDrug patch testing has been proposed as a helpful investigation upon suspecting drug allergy. We evaluated the value of drug patch testing in Cutaneous Adverse Drug Reactions (CADRs).MethodsAll patients with a diagnosis of CADRs were patch tested with suspected drugs.ResultsOf 122 patients with CADRs, 44.3% had at least one positive result after drug patch testing, P value = 0.312. Drug rash with eosinophilia and systemic symptom (DRESS) rendered the highest positive patch testing at 53.9%, followed by a maculopapular rash (MP) at 49.0%, fixed drug eruption (FDE) at 48.3%, lichenoid drug eruption and Stevens‐Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) at 25.0% each. Lichenoid drug eruption had the longest mean onset of almost 2.5 years. One hundred and twenty‐eight drugs and herbal medicines were tested. About 32.8% of these drugs gave a positive result, P value = 0.041. Nonsteroidal anti‐inflammatory drugs (NSAIDs) were the most common positive drug especially for fixed drug eruption (FDE), followed by antiretroviral and antibiotics, which were the most common positive drugs for MP. While anti‐Tuberculosis (anti‐TB) drugs and antihypertensives together with lipid‐lowering drugs were the most common for DRESS and lichenoid eruption, respectively. Subgroup analysis among HIV patients showed a 61.5% positive patch test. The median CD4 count in the positive group was 43.5 cells/mm3.ConclusionWe recommend drug patch testing as a safe method to identify the culprit drug in CADRs, especially DRESS, MP, and FDE. In HIV patients, the positive test was associated with low CD4 count and copositive reaction.
Effect of extraction type on the fatty acids profile and physicochemical properties of biolipids from Astrocaryum vulgare pulp: supercritical CO2 versus n‐hexane extractions
Authors: dos Santos Orquídea Vasconcelos , Pinaffi‐Langley Ana Clara da C. , Ferreira Maria Caroline Rodrigues , de Souza Amanda Larissa Garça , Carvalho‐Junior Raul Nunes , Teixeira‐Costa Barbara Elisabeth 
Published: October 2022

SummaryThis study aimed to investigate the effects of two, conventional and green, extraction techniques on the nutritional, bioactive and physicochemical properties of oils from Astrocaryum vulgare pulp. It is an Amazonian oilseed named tucumã, known by their oily nature and bioactive properties. n‐Hexane (N‐HE) and supercritical CO2 (SFE‐CO2) were used as extraction solvents. Higher oil yield, 39.63%, was achieved using N‐HE then SFE‐CO2, 36.75%. The SFE‐CO2 oil presented low acidity and peroxide content, 0.9 mg KOHg−1 and 1.1 mEq kg−1, while the N‐HE presented 3.25 mg KOH g−1 and 2.4 mEq kg−1, respectively (P < 0.05). The SFE‐CO2 oil exhibited greater content of linoleic (~42.3%) and oleic acids (~32.6%) (P < 0.05) and higher β‐carotenes, up to 1100 μg 100 g−1, while the N‐HE oil had ~877 μg 100 g−1. SFE‐CO2 had positive effect on the physicochemical and nutritional properties of A. vulgare pulp oil, which was statistically confirmed by principal component analysis (PCA).Practical applicationsThe application of green techniques based on supercritical CO2 fluid extraction to obtain biolipids from A. vulgare pulp with greater nutritional quality contributes to its potential utilisation as a functional ingredient in foods.
H1N1 G4 swine influenza T cell epitope analysis in swine and human vaccines and circulating strains uncovers potential risk to swine and humans
Authors: Tan Swan , Moise Lenny , Pearce Douglas S. , Kyriakis Constantinos S. , Gutiérrez Andres H. , Ross Ted M. , Bahl Justin , De Groot Anne S. 
Published: October 2022

AbstractBackgroundPandemic influenza viruses may emerge from animal reservoirs and spread among humans in the absence of cross‐reactive antibodies in the human population. Immune response to highly conserved T cell epitopes in vaccines may still reduce morbidity and limit the spread of the new virus even when cross‐protective antibody responses are lacking.MethodsWe used an established epitope content prediction and comparison tool, Epitope Content Comparison (EpiCC), to assess the potential for emergent H1N1 G4 swine influenza A virus (G4) to impact swine and human populations. We identified and computed the total cross‐conserved T cell epitope content in HA sequences of human seasonal and experimental influenza vaccines, swine influenza vaccines from Europe and the United States (US) against G4.ResultsThe overall T cell epitope content of US commercial swine vaccines was poorly conserved with G4, with an average T cell epitope coverage of 35.7%. EpiCC scores for the comparison between current human influenza vaccines and circulating human influenza strains were also very low. In contrast, the T cell epitope coverage of a recent European swine influenza vaccine (HL03) was 65.8% against G4.ConclusionsPoor T cell epitope cross‐conservation between emergent G4 and swine and human influenza vaccines in the US may enable G4 to spread in swine and spillover to human populations in the absence of protective antibody response. One European influenza vaccine, HL03, may protect against emergent G4. This study illustrates the use of the EpiCC tool for prospective assessment of existing vaccine strains against emergent viruses in swine and human populations.
Teacher–Artist Partnership Framework Within School Makerspaces to Foster Students’ Creativity
Authors: Santos Ieda M. , Menano Luisa , Habak Claudine 
Published: October 2022

AbstractCreativity is a fundamental skill to prepare individuals to work and live in a changing world. Educators have recognised its value and advocate that schools can provide an environment for fostering the creative thinking skills of students. Makerspaces are emerging in school contexts, and they carry great opportunities for engaging students in creative thinking processes. The school makerspace also offers a professional learning space for teachers and artists to collaborate to support students’ creative potential through making activities linked to the curriculum. This paper proposes a teacher–artist partnership framework within the makerspace to support mutual professional growth and opportunities to foster a learning environment conducive to creative expressions. The framework consists of three non‐linear and iterative processes, namely (a) developing craft knowledge, (b) co‐constructing knowledge, and (c) reflection and researching, supported by a community of practice and internal and external communities. Expected outcomes from the partnership for students, teachers and artists, and recommendations are discussed.
A systematic review on the use of action research methods in mental health nursing care
Authors: Moreno‐Poyato Antonio R. , Subias‐Miquel Martí , Tolosa‐Merlos Diana , Ventosa‐Ruiz Ana , Pérez‐Toribio Alonso , EL Abidi Kadhija , Navarro‐Maldonado Raquel , Suárez‐Pérez Raquel , Valera‐Fernández Rosario , Romeu‐Labayen Maria , Lluch‐Canut Teresa , Roldán‐Merino Juan , Puig‐Llobet Montserrat 
Published: October 2022

AbstractAimsTo identify and synthesize evidence on the use of action research methods in mental health nursing care.DesignSystematic review.Data SourcesCINAHL, Web of Science, PubMed and Scopus databases were searched in January 2021.Review MethodsData were selected using the updated Preferred Reporting Items for Systematic Reviews and Meta‐Analysis framework. Two reviewers independently conducted the study selection, and quality appraisal using Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research, data extraction and data analysis procedures.ResultsSixteen studies, half of which used participatory action research, were included in this review. Nurses, along with other stakeholders, were an active part of the action research process. The main topics of interest addressed were categorized as improving the adoption of a person‐centred approach to care and improving decision‐making procedures. The use of action research helped the participants to identify the meaning they attached to the topic of interest to be improved. Moreover, this method helped to identify needs and strategies for improving care. The studies concurred that the use of action research enabled participants to gain awareness, improve attitudes and acquire knowledge. In addition, it enabled participants to gain confidence and security in the group context, as key aspects of their empowerment.ConclusionThis review shows the usefulness of action research in any mental health nursing context, contributing to the improvement of care at both the individual and collective levels.ImpactThis paper demonstrates the use of the action research method in the field of mental health nursing. Its use has improved the clinical practice of nurses as well as that of teams in both community and hospital settings, addressing issues of the person‐centred approach to care and decision‐making procedures.
‘I'm still young… it doesn't matter’ – A qualitative study on the neglect of prodromal myocardial infarction symptoms among young‐ and middle‐aged adults
Authors: Yu Hong‐yu , Liu An‐kang , Qiu Wei‐yu , Su Jin , Zhou Xin‐yi , Gong Ni , Yang Qiao‐hong 
Published: October 2022

AbstractAimTo explore why young‐ and middle‐aged adults ignore prodromal myocardial infarction symptoms from a life course and sociocultural perspective.DesignA qualitative descriptive study.MethodsWe applied purposeful sampling to recruit participants from a tertiary hospital in Guangzhou from July to November 2021. Face‐to‐face interviews were performed. Interviews were audio‐recorded, transcribed verbatim and analysed using thematic analysis methods.ResultsTwenty‐four young‐ and middle‐aged adults diagnosed with acute myocardial infarction participated in this study. Analysis revealed three main themes: I'm still young, it will not happen to me; to be somebody and different roles, multiple pressures. Age‐related self‐confidence led to inappropriate perceptions and responses to prodromal symptoms among young‐ and middle‐aged adults. These individuals strived to align their behaviours and attention with social expectations and self‐expectations, underestimating the importance of perceiving the warning signs of acute myocardial infarction and seeking medical treatment. Pressure from social roles also prevented them from paying enough attention to prodromal symptoms.ConclusionTargeted social support, public education and technologies should be provided to these individuals since they are pillars of the family and society. We also highlight how nurses can function these strategies appropriately.ImpactsThis study contributes to a better understanding of the neglect of prodromal symptoms among young‐ and middle‐aged adults. Its results enhance our understanding of the perception of and coping with prodromal symptoms among this population, which will help avoid the burden caused by acute myocardial infarction.Patient or Public ContributionThe patients involved in our study shared their experiences and insights to provide new perspectives regarding the neglect of prodromal myocardial infarction symptoms among young‐ and middle‐aged adults.
In vivo tissue temperature during lesion size index‐guided 50W ablation versus 30W ablation: A porcine study
Authors: Otsuka Naoto , Okumura Yasuo , Kuorkawa Sayaka , Nagashima Koichi , Wakamatsu Yuji , Hayashida Satoshi , Ohkubo Kimie , Nakai Toshiko , Hao Hiroyuki , Takahashi Rie , Taniguchi Yoshiki 
Published: October 2022

AbstractBackgroundNeither the actual in vivo tissue temperatures reached with lesion size index (LSI)‐guided high‐power short‐duration (HPSD) ablation for atrial fibrillation nor the safety profile has been elucidated.MethodsWe conducted a porcine study (n = 7) in which, after right thoracotomy, we implanted 6–8 thermocouples epicardially in the superior vena cava, right pulmonary vein, and esophagus close to the inferior vena cava. We compared tissue temperatures reached during 50 W‐HPSD ablation with those reached during standard (30 W) ablation, both targeting an LSI of 5.0 (5–15 g contact force).ResultsTmax (maximum tissue temperature when the thermocouple was located ≤5 mm from the catheter tip) reached during HPSD ablation was modestly higher than that reached during standard ablation (58.0 ± 10.1°C vs. 53.6 ± 9.2°C; p = .14) and peak tissue temperature correlated inversely with the distance between the catheter tip and the thermocouple, regardless of the power settings (HPSD: r = −0.63; standard: r = −0.66). Lethal temperature (≥50°C) reached 6.3 ± 1.8 s and 16.9 ± 16.1 s after the start of HPSD and standard ablation, respectively (p = .002), and it was best predicted at a catheter tip‐to‐thermocouple distance cut point of 2.8 and 5.3 mm, respectively. All lesions produced by HPSD ablation and by standard ablation were transmural. There was no difference between HPSD ablation and standard ablation in the esophageal injury rate (70% vs. 75%, p = .81), but the maximum distance from the esophageal adventitia to the injury site tended to be shorter (0.94 ± 0.29 mm vs. 1.40 ± 0.57 mm, respectively; p = .09).ConclusionsActual tissue temperatures reached with LSI‐guided HPSD ablation appear to be modestly higher, with a shorter distance between the catheter tip and thermocouple achieving lethal temperature, than those reached with standard ablation. HPSD ablation lasting <6 s may help minimize lethal thermal injury to the esophagus lying at a close distance.
Modulation of the activity of histone lysine methyltransferases and demethylases by curcumin analog in leukaemia cells
Authors: Sawesi Suhila , Malkaram Sridhar A. , Abd Elmageed Zakaria Y. , Fandy Tamer E. 
Published: October 2022

AbstractCurcumin is a known epigenetic modifier that demonstrated antitumor effect in different types of cancer. The poor solubility and metabolic stability are major drawbacks that limit its development as an antitumor agent. Dimethoxycurcumin (DMC) is a more soluble and stable curcumin analog. In this study, we compared the effect of both drugs on a variety of histone posttranslational modifications and on the activity of histone lysine methyltransferase (HKMTs) and demethylase (HKDMTs) enzymes that target the H3K4, H3K9 and H3K27 epigenetic marks. Mass spectrometry was used to quantitate the changes in 95 histone posttranslational modifications induced by curcumin or DMC. The effect of both drugs on the enzymatic activity of HKMTs and HKDMs was measured using an antibody‐based assay. Mass spectrometry analysis showed that curcumin and DMC modulated several histone modifications. Histone changes were not limited to lysine methylation and acetylation but included arginine and glutamine methylation. Only few histone modifications were similarly changed by both drugs. On the contrary, the effect of both drugs on the activity of HKMTs and HKDMs was very similar. Curcumin and DMC inhibited the HKMTs enzymes that target the H3K4, H3K9 and H3K27 marks and increased the activity of the HKDMs enzymes LSD1, JARID and JMJD2. In conclusion, we identified novel enzymatic targets for both curcumin and DMC that support their use and development as epigenetic modifiers in cancer treatment. The multiple targets modulated by both drugs could provide a therapeutic advantage by overcoming drug resistance development.
Epidemiology of aplasia cutis congenita: A population‐based study in Europe
Authors: Coi Alessio , Barisic Ingeborg , Garne Ester , Pierini Anna , Addor Marie‐Claude , Aizpurua Atxega Amaia , Ballardini Elisa , Braz Paula , Broughan Jennifer M. , Cavero‐Carbonell Clara , de Walle Hermien E. K. , Draper Elizabeth S. , Gatt Miriam , Häusler Martin , Kinsner‐Ovaskainen Agnieszka , Kurinczuk Jennifer J. , Lelong Nathalie , Luyt Karen , Mezzasalma Lorena , Mullaney Carmel , Nelen Vera , Odak Ljubica , O'Mahony Mary T. , Perthus Isabelle , Randrianaivo Hanitra , Rankin Judith , Rissmann Anke , Rouget Florence , Schaub Bruno , Tucker David , Wellesley Diana , Wiśniewska Katarzyna , Yevtushok Lyubov , Santoro Michele 
Published: October 2022

AbstractBackgroundAplasia cutis congenita (ACC) is a rare congenital anomaly characterized by localized or widespread absence of skin at birth, mainly affecting the scalp. Most information about ACC exists as individual case reports and medium‐sized studies.ObjectivesThis study aimed to investigate the epidemiology of ACC, using data from a large European network of population‐based registries for congenital anomalies (EUROCAT).MethodsTwenty‐eight EUROCAT population‐based registries in 16 European countries were involved. Poisson regression models were exploited to estimate the overall and live birth prevalence, to test time trends in prevalence between four 5‐year periods and to evaluate the impact of the change of coding for ACC from the unspecific ICD9‐BPA code to the specific ICD10 code. Proportions of ACC cases associated with other anomalies were reported.ResultsFive hundred cases were identified in the period 1998–2017 (prevalence: 5.10 per 100,000 births). Prevalence across 5‐year periods did not differ significantly and no significant differences were evident due to the change from ICD9 to ICD10 in ACC coding. Heterogeneity in prevalence was observed across registries. The scalp was the most common site for ACC (96.4%) and associated congenital anomalies were present in 33.8% of cases. Patau and Adams–Oliver syndromes were the most frequent among the associated chromosomal anomalies (88.3%) and the associated genetic syndromes (57.7%), respectively. 16% of cases were associated with limb anomalies and 15.4% with congenital heart defects. A family history of ACC was found in 2% of cases.ConclusionTo our knowledge, this is the only population‐based study on ACC. The EUROCAT methodologies provide reliable prevalence estimates and proportions of associated anomalies.
Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta‐analysis
Authors: Jena Anuraag , Kumar‐M Praveen , Kumar Antriksh , Birda Chhagan Lal , Choudhury Arup , Kumar Naveen , Ramai Daryl , Facciorusso Antonio , Samanta Jayanta 
Published: October 2022

AbstractBackground and AimLiver involvement in celiac disease (CeD) is known but its various etiologies and the effect of gluten free diet (GFD) on it is understudied.MethodsWe searched PubMed, Medline and Embase databases from date of inception to March 7, 2022, to look for studies reporting on CeD and liver abnormalities. Pooled proportion of CeD patients with deranged transaminases, etiologies of various other liver diseases with CeD and the response to GFD were estimated. Subgroup analyses based on the age group, geographic distribution and duration of GFD were also carried out.ResultsTotal 42 studies (8976 patients) reported hyper‐transaminasemia in patients with celiac disease. The pooled proportion of patients with elevated transaminases was 21.42% (95% CI: 17.02–26.59, I2 = 94%) overall, with similar prevalence among adults (21.20%) and children (21.51%). The commonest etiology was celiac hepatitis at 49.23% (95% CI: 30.09–68.59, I2 = 87%). Compliance with GFD was noted in 90.27%. The proportion of CeD patients with liver abnormalities who showed response to GFD was 86.39% (95% CI: 80.04–90.95, I2 = 74%) overall.ConclusionLiver involvement was noted in 21.42% of CeD patients. Celiac hepatitis was reported in nearly half of them. Good compliance and response were noted with GFD.
A Model of QE, Reserve Demand, and the Money Multiplier
Authors: RYAN ELLEN , WHELAN KARL 
Published: October 2022

AbstractQuantitative easing (QE) programs have driven unprecedented expansions in the supply of central bank reserves around the world over the past two decades, fundamentally changing the implementation of monetary policy. The collapse in money multipliers following QE episodes has often been interpreted as implying banks are happy to passively hold most of the reserves created by QE. This paper develops a simple microsimulation model of the banking sector that adapts the traditional money multiplier model and allows for bank reserve demand to be inferred from monetary aggregates. The model allows the use of unwanted reserves by banks to play out over time alongside QE purchases and incorporates both significantly higher reserve demand after 2008 and capital constraints. With these additions, the model explains the persistently lower money multipliers seen in the United States following QE, as well as the growth in commercial bank deposits. The model suggests the demand from banks for reserves has increased substantially since the introduction of QE but not to the point where banks are passively absorbing all newly created reserves.
How Powerful Is Unannounced, Sterilized Foreign Exchange Intervention?
Authors: NAEF ALAIN , WEBER JACOB P. 
Published: October 2022

AbstractThough most central banks actively intervene on the foreign exchange market, the literature offers mixed evidence on their effectiveness: particularly for unannounced interventions. We use new, declassified data from the archives of the Bank of England and the institutional features of the Bretton Woods Era to estimate the effects of intervention on the exchange rate. We find that a purchase of pounds equivalent to 1% of the money supply causes a statistically significant, 4–5 basis point appreciation in the pound.