bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the glucocorticoid receptor co-chaperone FKBP5 in individuals with first-episode psychosis
Authors: Theodoridou D. , Vlaikou A. M. , Karampas A. , Georgiou G. , Filiou M.D. , Syrrou M. , Petrikis P. 
Published: February 2022

IntroductionStress has been associated with the onset and progression of neuropsychiatric conditions. The neuroendocrine response to psychosocial stressors is mediated via the hypothalamus-pituitary-adrenal axis, resulting in systemic glucocorticoid secretion. FKBP5 is a co-chaperone of the cortisol-bound glucocorticoid receptor. FKBP5 Single Nucleotide Polymorphisms (SNPs) may indicate stress-response alterations, thus affecting vulnerability or resilience to neuropsychiatric phenotypes.ObjectivesTo investigate the FKBP5 polymorphism rs1360780 and FKBP5 mRNA levels in a well-characterized, drug-naïve sample of First-Episode Psychosis (FEP) individuals and matched controls.MethodsFor genotyping rs1360780, whole blood DNA was extracted from FEP individuals and matched controls. The presence of the C (protective)→T (risk) alleles was assessed using TaqMan SNP genotyping assay. Peripheral Blood Mononuclear Cells (PBMCs) were isolated and whole RNA was extracted. FKBP5 mRNA levels were detected with RT-qPCR, using SYBRgreen. Results were normalized against the 18s rRNA reference gene. Statistical analysis was performed in GraphPad Prism 8.ResultsThe distribution of C→T alleles of rs1360780 genotyped in FEP (N=44) and controls (N=39) indicate a statistically significant prevalence of the C/C alleles in FEP individuals (*p=0.0432). mRNA FKBP5 data revealed increased levels of FKBP5 in FEP individuals (N=25) compared to controls (N=18), (***p=0.0007).ConclusionsOur data show increased FKBP5 mRNA levels in FEP individuals compared to matched controls, as well as the presence of the rs1360780 protective (C) allele. Follow up studies include investigation of the translational profile of stress-mediators, in order to pave an individualized approach towards deciphering psychosis onset pathobiology.DisclosureNo significant relationships.
Psychotropic medication for challenging behavior in people with learning disabilities in Qatar
Authors: Eltorki Y. , Tahir M. El , Husein B. El , Abdallah O. 
Published: February 2022

IntroductionChallenging behavior is a common reason for referral to psychiatric service. Psychotropic medications widely used to modify behaviors, even when no evidence of diagnosable mental illness. However, literature show little evidence that benefits outweigh the risks in their prescription. Monitoring using International guidelines may help improving the outcomes. We audit current practice against known standards.Objectives- To assess adherence within the Qatar Mental Health Services to National guidelines on using medication to manage behavior problems in adults with a learning disability. - To identify strengths and weaknesses in current practice. - To Make recommendations to improve LD patient careMethodsPatients with LD attending psychiatric clinic screened using selection and exclusion criteria and data collected and analyzed using format from the International standards.Results102 patients screened, 85 selected and 17 cases excluded Age range 18 to 50 years. 27% mild, 29% moderate and 44% severe LD, Autism 40% Psychiatric Diagnosis 55% Challenging behavior 45% Antipsychotic prescribing: 79% Rationale documented in 74%, Capacity assessment in 81%, Review of side effects in 53% Safety of medication in 61%, Medication discontinuation in 66%, Reasons for discontinuation in 36%ConclusionsAntipsychotics use (79%) is high with several combinations of IM and oral or more than 2 drugs. There is need for improvement across all standards. Rationalising the prescribing for LD patients to improve the outcomes for the safety of these patients. The audit indicate need for specialist service to monitor prescribing and apply standards of care in clinical service.DisclosureNo significant relationships.
Study of changes in neuropsychological indicators in adults
Authors: Sidenkova A. 
Published: February 2022

IntroductionCurrently, the number of cases of pathological aging of the CNS, represented by a violation of cognitive functions, is increasing. But there is a social request to prolong the physical and mental activity of older peopleObjectivesThe study of the dynamics of cognitive aging is timely and relevant. The article contains a report on a cohore non-repeating study of higher brain functions at various age periodsMethodsThe average age was 45.1 + 5.7 years. Inclusion criteria: 1. Dextral. Non-inclusion criteria: 1. Clinically significant somatic diseases in their medical history. 2. Mental disorders in their medical history. •Applied neuropsychological, statistical research methods. The research tool was the neuropsychological rapid method including the subtests: •“Memorizing 9 words in three presentations (1st, 2nd, 3rd attempts)”, •“Sequential subtraction”, •“Test of Benton’s visual memory”, •“Solving an arithmetic problem”, •“Overlaid images”, •“Specified flow of associations in 1 minute”, • “Figure of 3 geometric figures”, • “Blind hours”, • “Graph-motor test”, “Delay word reproduction”ResultsThe first cohort 27–40 years old. The second cohort 41–50 years old.Third cohort 51 years old and older. A significant difference in the performance of the graphomotor test between the subjects of the age subgroup of 27-40 years and the subgroup of 41-50 years was statistically confirmed. In older people revealed a much greater number of errors, interruptions of the test than the representatives of the more “young” subgroupConclusionsThe deterioration in the performance of the graphomotor test was the most age-specificDisclosureNo significant relationships.
Prevalence of psychological disorders among caregivers of children with intellectual disabilities and motor disabilities in Shiraz
Authors: Bakhshisamarin F. , Mirzaei S. , Ansarizangakani F. , Mousavi L. , Sorifijini A. 
Published: February 2022

IntroductionThe prevalence of mental disorders plays an important role in identifying the state of mental health of the community and estimate the required facilities at any time.ObjectivesTherefore, the purpose of this study was to investigate the prevalence of psychological disorders in caregivers of children with intellectual disabilities and motor disabilities in Shiraz.MethodsThe research was descriptive and cross-sectional survey. The statistical population consisted of all mothers of children with disabilities who were admitted to welfare centers and clinics of Shiraz in 2019. Of these families, 35 mothers with children with intellectual disability and 35 mothers with children with motor disability were selected as the sample group. SCL-90-R (1976) was used to collect of data. For analyze the data, MANOVA test was used.ResultsThe results of this study showed that the most common psychological disorders in caregivers of children with intellectual disability were aggression (hostility), hypersensitivity to interpersonal relationships, anxiety and depression, and in caregivers of children with motor disabilities were physical complaints, sensitivity to interpersonal relationships, paranoid thoughts and anxiety.ConclusionsAccording to the findings of this research, it can be concluded that caregivers of children with special needs in terms of mental health are not in a favorable situation, which is due to the lack of proper adaptation with the disability of their child and the failure to meet their needs.DisclosureNo significant relationships.
Occupational stress and mental suffering among emergency staff
Authors: Dhouib F. , Kotti N. , Masmoudi R. , Hrairi A. , Hammami K. Jmal , Masmoudi M. Larbi , Masmoudi J. , Hajjeji M. 
Published: February 2022

IntroductionIn emergency departments, workers regularly report unfavorable working conditions. It’s a stressful workplace with excessive workloads, high demands on patient care including exposure to violence, time pressures and overcrowding.Objectives-Identify the prevalence of violence, psychological distress and job stress in the emergency department. -Investigate risk factors of aggression among emergency department staff.MethodsThis study is a descriptive-cross sectional analysis study conducted on emergency department staff. Data were collected through a questionnaire including sociodemographic information, circumstances of the aggression, the Karasek questionnaire, and the GHQ-12 (General Health Questionnaire).ResultsOur study included 62 health workers. Half of the population were physicians. The prevalence of assault was estimated at 59.6%. Psychological distress was noted in 64.5% of cases. Occupational stress was estimated at 75.8%. The most common type of assault was verbal aggression (86.4%). The aggressor was most often an accompanying person. The occurrence of violence was not associated with the worker’s psychological distress or job stress. On the other hand, we noted an association between aggression and variable work schedule.ConclusionsViolence against healthcare workers in the emergency department is an important phenomenon. Preventive actions should be taken to improve health professional wellbeing at work.DisclosureNo significant relationships.
The impact of experiences of violence on the physical and mental health of a portuguese sample
Authors: Esgalhado G. , Ferreira L. 
Published: February 2022

IntroductionViolent Experiences result in economic and social costs for society, impacting on emotions in families, on health (both physical and mental), and overall quality of life, causing potential damages. Thus, it becomes relevant to do research on this impact, aiming at raising awareness and promoting prevention.ObjectivesThe purpose of the study is to estimate the impact of experiences of violence on both physical and mental health taking into account variables such as age, gender, and marital status.MethodsThis is a cross-sectional study sampling 1407 Portuguese speaking adults, with an age average of 42 years old (DP=17.28). The measures used were: The SF-36 questionnaire to assess quality of life, physical and mental health, and the Experiences of Violence Questionnaire.ResultsThe sample was divided into two groups (victims and non-victims). The group of participants that were not subjected to violence presents more positive results. In relation to the comparison between genders, it was verified that males present more positive results having into account all dimensions SF-36 when compared to women. Also, older participants (53 years old or more) presents lower results of general health.ConclusionsViolence and health, increasingly related due to the impact it has on the subjects’ physical and mental health and quality of life.DisclosureNo significant relationships.
Trauma: Harmful effect of diagnostic labeling and iatrogenic intervention for the recovery process
Authors: Villarroel C. Martín , Garcia L. Carpio , Matsuura J. , Revuelta M. Sánchez , García G. Belmonte , Cutanda J. Dominguez , Daza M. Fernández-Torija , García E. 
Published: February 2022

IntroductionWe know the coexistence of traumatic factors (loss of affective relationships, experiences of abuse, extreme risk situations, etc.) is common in psychiatric pathologies in which level of stress experienced exceeds normal capacity of the person, favoring the appearance of dissociative or excision mechanisms. A common mistake is to pathologize them and try to eliminate them.ObjectivesThe objective of this paper is to study trauma and defense mechanisms involved, in order to carry out a better approach.MethodsA bibliographic search was performed from different database (Pubmed, TripDatabase) about trauma, mechanisms involved and the construction of identity.ResultsWe know neural pathways mature asymmetrically in evolutionary development (functions related to attention, concentration and executive function having special importance) and thus, traumas occurred in moments of greatest vulnerability such as early childhood, can damage and interfere with the correct integration of neural processes, producing disproportionate and unnecessarily maintained alert responses (common basis for many pathologies such as borderline personality disorder or traumatic psychosis). In response to this, reactive mechanisms are produced (such as dissociation or cleavage) that are not necessarily pathological and therefore, we should not always intervene by eliminating them because they often function as a protective factor, allowing to preserve functioning and favoring recovery.ConclusionsIn conclusion, we need a better understanding of mechanisms involved in trauma, executive function and the alarm system beyond anxiety reactions, trying to understand the function of symptom without eliminating it, but evaluating whether there are healthier alternatives can be promoted for the complete recovery of the patient.DisclosureNo significant relationships.
The effect of psychoeducation regarding relaxation breathing, in stress reduction in a sample of nurses in a Greek hospital
Authors: Lyrakos G. , Androutsos D. , Aslani E. , Spinaris V. 
Published: February 2022

IntroductionStress is one of the biggest problems leading a large portion of people to seek medical or psychotherapeutic management, while a large portion of hospital staff report high levels of work-related stress.ObjectivesThe purpose of this intervention was to implement a psychoeducation seminar on stress management by implementing diaphragmatic breathing exercises and to detect the reduction of its levels in nursing staff.MethodsThe study took place at the General Hospital of Nikaia. Fifty employees, 38 women, aged 20-60 (M=37.4±10.5) participated in a two-hour group psychoeducation workshop, concerning psychoeducation on stress and application in diaphragmatic breathing exercises. The measurement of the success of the intervention was performed using a proportional stress assessment scale before and after the intervention. Statistical analysis was performed with SPSS26.ResultsStress levels before the intervention ranged from 0 to 10 (M=5.7±5.7) while after the intervention ranged from 0 to 7 (M=2.3±2.04). Age did not appear to play a role in stress reduction, but was found to be positively and significantly associated with pre-existing stress in employees (r=0.423 p=0.002). On the contrary, gender was found to be related both to the pre-existence of stress, with women reporting the highest levels (t=-3.534 p=0.001), and to the reduction of stress after the intervention (t=-2,534 p=0.001).ConclusionsThe above findings indicate the importance of implementing group psychoeducation programs to reduce stress at the organizational level, a very important result considering the cumulative effect that the recent existence of covid-19 has had on nursing staff.DisclosureNo significant relationships.
Functional impairments in ADHD in function of anxiety, depressive and somatic complains in Brazilian young adults
Authors: Carreiro L.R. , Silva M. , Paes I. 
Published: February 2022

IntroductionComorbidities between Anxiety Disorders, Depressive Disorders or Somatic Symptoms, and Attention Deficit Hyperactivity Disorder (ADHD) can cause variability in the functional impairments faced by young adults. Knowing the possible configurations resulting from these comorbidities is important for a better understanding of the cases, diagnostic processes, and proposed treatments.ObjectivesTo verify associations between indicators of the aforementioned mental disorders, and symptoms of inattention or hyperactivity-impulsivity, and functional impairments in different areas of life, related to ADHD.MethodsThere were 27 participants (23 women, age m = 22.5 sd = 1.8, education m = 15.7 sd = 2.2), with complaints of inattention and hyperactivity-impulsivity compatible with ADHD, screened with ASRS-18 score> 24 and WASI IQ> 79, and assessed by DIVA-2.0 (symptoms of ADHD), ASR-ASEBA (depressive, anxiety and somatic problems), EPF-ADHD (functional impairments in the academic, professional, affective, domestic, social, health, financial, traffic areas and legal risk). Spearman’s Correlation analysis was performed in the SPSS program (significance p <0.05).ResultsIncrease in depressive problems associated with increased symptoms of inattention (rho=0.386, p=0.049) and hyperactivity-impulsivity (rho = 0.406, p = 0.036). Increased somatic problems associated with increased functional impairment in health (rho=0.458, p=0.016). Increase in depressive problems associated with increased losses in the academic (rho=0.437, p=0.023), affective (rho=0.408, p=0.034), domestic (rho=0.550, p=0.002), social (rho=0.445, p=0.002), financial (rho=0.389, p=0.045) and health (rho=0.514, p=0.006).ConclusionsADHD with comorbidities can have a peculiar clinical evolution with specific characteristics, including diagnosis, management, and response to treatment. These subgroups with different intervention needs demand outlining needs and personalized treatment.DisclosureNo significant relationships.
Organizational environment as a factor of physicians’ psychological well-being
Authors: Abdullaeva M. , Abdullayeva G. 
Published: February 2022

IntroductionThe importance of ensuring the well-being of physicians is determined by the serious changes in medical organizations that transform the traditional “doctor - patient” relationship and set different indicators of the medical care quality (Melnyk et al., 2020; Sandy et al., 2019; Tawfik et al., 2019).ObjectivesThe main objective was to study the characteristics of the well-being of physicians working in public and commercial medical institutions. The difference in these “environments” is the degree of independence and responsibility in the course of diagnosis and treatment.MethodsThe study involved 102 people: 66 of them are employees at public hospitals, 36 –at commercial medical centers. The respondents were offered a methodic package aimed to diagnose: career orientations; the degree of satisfaction with various work aspects; severity of burnout symptoms; subjective assessment of their work.ResultsThe estimating factor analysis identified 3 factors (73% of the total variance of the data) –such as emotional acceptance of one’s work, stress and tension, intellectual workload. The indicator of emotional exhaustion among physicians of commercial centers is significantly higher than that of doctors of public hospitals, which indicates a greater emotional involvement in the situation of providing paid services (p≤0.007).ConclusionsThe main direction of psychological work with physicians of commercial institutions is teaching them to regulating the emotional state and to master communicative techniques. An important part of psychological support of physicians in public hospitals is to provide a favorable psychological climate that ensures the professional growth and adherence to humane principles of working with patients.DisclosureNo significant relationships.
Psychiatric care in university population
Authors: Espada N.M. Casado , Flores A. , López M.T. Lozano , Bonaechea B. Bote , García A.B. Sánchez , Rodríguez M. , Roncero C. 
Published: February 2022

IntroductionIt is well-known that university students experience high levels of mental health problems (1). University life presents changes and challenges that can be stressful and may affect the mental health of its community (2,3). More than 20 years ago, the Social Affairs Service (SAS) of the University of Salamanca started a program that ensured the mental health care in their community. The Psychiatric Care Unit is part of this program and its objectives are: 1) to detect serious mental disorders; 2) treat mild mental disorders; 3) give information to prevent illness and promote mental health; 4) serve as support in patients with previous follow-up that has been discontinued due to the beginning of their studies; 5) liaise with referral psychiatrists.ObjectivesTo make known a Psychiatric Care Unit targeted in the university communityMethods18 people between 19 and 52 years old (22% male, 78% female) were evaluated between November and December of 2020 in the Psychiatric Care Unit of the Social Affairs Service (PCU-SAS, University of Salamanca). The assessment consisted in an interview carried out by a psychiatrist, in the presence of a medical graduate. Every patient belong to the university community (students/ staff).ResultsThe most frequent diagnosis in the sample is Adjustment Disorder (F43.2). Substance use, eating disorders, low-self-concept, perfectionism and emotional dysregulation are very prevalent symptoms along our sample.ConclusionsUniversities should invest in creating environments that promote student and staff mental wellbeing. However, the current body of evidence is scarce and more research is needed to recommend what are the best strategies(4).DisclosureNo significant relationships.
Burnout in medical residents - a prospective study in Albania
Authors: Alikaj V. , Skendi V. , Metaj E. , Dashi E. 
Published: February 2022

IntroductionBurnout is a syndrome characterized by the high workload in the workplace, which is very common in hospital settings. Medical trainees and early career physicians are more likely to experience burnout than their non-medical peers. Burnout has been linked with a great number of consequences, whether personal, family or work related. Physicians burnout specifically, is related to high rates of medical errors, lack of professionalism, decreased productivity but also to suicidal ideation, depression and substance abuse.ObjectivesThe aim of this study is to investigate the level of burnout in medical residents at University Hospital Center “Mother Theresa” Tirana, changes in burnout depending from the year of study, specialty or associated demographic factors.MethodsThis is a prospective study conducted over two time periods, in 2017 and 2019 using the Maslach Burnout Inventory - short version questionnaire. The information was obtained through the direct filling in of the printed questionnaires, by the residents in their workplace.ResultsWe collected 137 responses from different medical specialties where 15,3% were psychiatric residents. About 70 % of residents are females and 40% of residents where in their third year of residency by the time they completed the questionnaire. 68% of residents declared more than one night shift within a week.ConclusionsResidents are given great responsibility coupled with low levels of control, placing them at risk for role problems such as role ambiguity, role conflicts or role overload. Moreover, medical residents are relatively young and at the beginning of their careers, which makes them vulnerable to burnout.DisclosureNo significant relationships.