bluuebunny/crossref_metadata_2025_split huggingface dataset:
To explore the application of HMGB1, SII, S100A8 / A9 and MCP-1 in the diagnosis, condition monitoring and prognosis of rheumatoid arthritis
Authors: Xiang Yuling , Zhang Bin , Lai Xin , Han Kexin , Li Juan , Song Liyun , Tan Liming 
Published: November 2022

Abstract
Objective: To explore the diagnosis and prognosisvalue of high mobility group box1 protein B1(HMGB1), systemic immune inflammatory index (SII), calcium binding proteinA8/A9 complex (S100A8/ A9) and monocyte chemoattractant protein-1 (MCP-1) in rheumatoid arthritis (RA).
Methods: From January 2020 to December 2021, 154 patients diagnosed with RA in the outpatient and inpatient clinics of the Second Affiliated Hospital of Nanchang University and Yingtan People's Hospital were selected as the RA group, A total of 303 cases including 78 cases of Sjogren's syndrome (SS), 62 cases of systemic lupus erythematosus (SLE), 79 cases of ankylosing spondylitis (AS) and 84 cases of osteoarthritis (OA) were selected as as a non-RA group, and 43 healthy people who underwent physical examination at the same time in the hospital were selected as the healthy control group.The levels of HMGB1, S100A8/A9 and MCP-1 were detected by enzyme-linked immunosorbent assay (ELISA), platelets (PLT) and lymphocytes (L) were detected by sheath flow electrical impedance method, neutrophils (N) were detected by flow cytometry combined with fluorescence staining,(N), calculate SII and detect other laboratory indicators.The disease activity index 28 (DAS28) score was used to evaluate the disease activity of RA and the efficacy after treatment,the patients with RA were followed up at 1 month, 2 months and 3 months after treatment, and the correlation between the detection indicators in each period was analyzed.
Results: ① the levels of HMGB1, SII, S100A8/A9 and MCP-1 in RA group were significantly higher than those in healthy control group (P < 0.01),and the AUC area of RA diagnosis was 0.86, 0.79, 0.84 and 0.80, respectively, the AUC area of HMGB1 was the largest. ② The positive rates of HMGB1, SII, S100A8 / A9 and MCP-1 in RF (-) and Anti-CCP (-) groups were 37.50%, 37.50%, 50.00% and 62.5%, respectively. The positive rate of MCP-1 was the highest. ③ The levels of HMGB1, S100A8 / A9 and MCP-1 in high disease activity group and middle disease activity group were higher than those in low disease activity group, remission group and healthy control group (P < 0.05).④ HMGB1, SII, S100A8 / A9 and MCP-1 were positively correlated with DSA28 score (r= 0.476, 0.286, 0.522 and 0.441, respectively, P < 0.01); Δ HMGB1, Δ SII, Δ S100A8 / A9 and Δ MCP-1 and Δ DAS28 before and after treatment in RA patients was positively correlated (r = 0.628, 0.524, 0.603 and 0.579, P < 0.01).
Conclusion: HMGB1, SII, S100A8/A9 and MCP-1 show better diagnostic performance in RA, especially improving the detected rate of RF (-) and Anti-CCP (-) RA patients;Besides,HMGB1, SII, S100A8/A9 and MCP-1 can be used for disease activity monitoring and disease evaluation of RA patients.
Plasma-derived Exosomal microRNA expression profile in Lung Adenocarcinoma with OSA
Authors: Chen Jianan , Lu Minzhen , Gao Xinglin 
Published: November 2022

Abstract
Background
Obstructive sleep apnea(OSA) was reported to involve in lung carcinogenesis. Altered expression of miRNAs that are secreted from exosomes is involved in the occurrence of various malignant tumors including lung adenocarcinoma (LUAD).
Methods
We investigated the differential expression of plasma exosomal miRNAs in LUAD patients with OSA compared to matched LUAD patients without OSA by high-throughput sequencing and verified the candidate miRNAs by quantitative real-time PCR (qPCR).
Results
In total, 78 differentially expressed exosomal-miRNAs including 44 up-regulated and 34 down-regulated were obtained through high-throughput sequencing. Subsequently, validation studies performed by qPCR revealed that the expression level of exosomal miR-107 was significantly higher in LUAD with OSA(n = 18) than LUAD patients without OSA(n = 18). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the PI3K-Akt pathway is targeted by miR-107 and may be involved in lung carcinogenesis under the intermittent hypoxia condition.
Conclusion
Aberrant profiling of plasma-derived microRNAs was identified and miR-107 may play a crucial role in the carcinogenesis of lung adenocarcinoma under the intermittent hypoxia condition.
Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation
Authors: Cakmak Yusuf O. , Khwaounjoo Prashanna , Pangilinan Joseph , Wise Innes K. , Burrows Chris , Kolakshyapati Pranish , Williams Zoe , Bannon Paul 
Published: November 2022

Abstract

Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs’ blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80Hz, 10Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal or Abdominal and Hind Limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.
Experimental study of friction pair of variable stator vane system and its mechanism dynamic modeling application
Authors: Chang Jing , Luo Zhong , Wang Yunlei , Han Qingkai , Han Fangjun , Zhang Hongwei 
Published: November 2022

Abstract
For the study of joint characteristics of the real variable stator vane (VSV) mechanism, the dry friction properties of joint materials must be taken into account. In this paper, a micro hybrid contact force model considering the friction characteristics of real revolute joint materials is proposed, and then it is utilized for the dynamic analysis of a principle-level VSV mechanism test rig, including the dry friction rotary pair, designed based on the similitude scaling theory. For the tribological characteristics of real materials, the friction tests and the vibration tests induced by the friction process are carried out. Then the friction coefficient values obtained from the test are embedded into the contact force model considering friction factors and compared with several other macro contact force models. The accuracy of the hybrid model is verified through a one-shot contact-impact simulation. Finally, the hybrid contact force model is used to analyze the influence of different driving methods on the dynamic characteristics of the system. The results showed that the driving method of constant speed has good stability and is a good recommendation for engineering applications.
Three-dimensional molecular architecture of mouse organogenesis
Authors: Peng Guangdun , QU Fangfang , Xu Jian , Li Wenjia , Zhang Ruifang , Ke Jincan , Ren Xiaodie , Meng Xiaogao , Qin Lexin , Zhang Jingna , Lu Fangru , Zhou Xin , Luo Xi , Zhang Zhen , Wu Guangming , Pei Duanqing , Chen Jiekai , Cui Guizhong , Suo Shengbao 
Published: November 2022

Abstract
Mammalian embryos have sophisticated cell organizations that are orchestrated by molecular regulation at cellular and tissue level. It has recently been appreciated that the cells that make up the animal body themselves harbor significant heterogeneity in the context of both cellular and particularly spatial dimension. However, current spatial transcriptomics profiling of embryonic tissues either lack three-dimensional representation or are restricted to limited depth and organs. Here, we reported a holistic spatial transcriptome atlas of all major organs at embryonic day 13.5 of mouse embryo and delineated a 3D rendering of the molecular regulation of embryonic patterning. By integrating with corresponding single-cell transcriptome data, the spatial organogenesis atlas provides rich molecular annotation of the dynamic organ nature, spatial cellular interaction, embryonic axes and divergence of cell fates underlying mammalian development, which would pave the way for precise organ-engineering and stem-cell based regenerative medicine.
Numerical simulation research on welded residual stress and distortion of aero-engine afterburner lobe mixer with different welding sequences
Authors: jin hongxi , Chen Zhenlin , Liu Xiangbo , Wei Yanhong , Chen Jicheng 
Published: November 2022

Abstract
Most thin-walled parts of aero-engines with intricate surfaces, such as lobe mixer, are welded using tungsten inert gas (TIG), which will certainly induce stress and distortion, causing a serious influence on assembly accuracy. The objective of this study was to establish a finite element model to optimize TIG wire filler welding sequence for an aero-engine lobe mixer composed of GH3044 nickel-based superalloy at the thickness of 2 mm. A new method for optimizing residual stress and deformation in the welding of large-size components was proposed.We carried out a 2 mm thickness plate TIG wire filler welding experiment to obtain the ideal process parameters and validate the heat source model and thermal boundary condition, and also designed a set of frock clamp.The stress and distortion of the lobed mixer were analyzed under various welding sequences based on the established finite element model. The results of the study showed that the peak residual stress difference of the lobe mixer is smaller using such a fixture. Different welding sequences affected the stress uniformity throughout the structural member. The symmetrical welding of single weld was a better process, with a peak distortion of only 0.54 mm and uniform stress distribution.
Impact of a postpartum care rehabilitation program to prevent postpartum depression at a Secondary Municipal Hospital in Qingdao China: a cross-sectional study
Authors: Zhang Xiaoqian , Zuo Xiaoli , Matheï Catharina , Aertgeerts Bert , Afnan Masoud , Li Tang , Buntinx Frank , Vermandere Mieke 
Published: November 2022

Abstract
Background
The emerging postpartum rehabilitation (PPR) program in Chinese hospitals characterized by applying ongoing medical care through traditional cultural practices shows a protective effect in early puerperium in China. This study explores the benefit of PPR program practices to postpartum depression (PPD) and other possible influencing factors for PPD among Chinese women during the first postnatal six weeks.
Methods
The cross-sectional study included 403 participants and was conducted in a Secondary Municipal Hospital in Qingdao, China, from 01 December 2018 to 31 December 2021. Information on this PPR program was collected during the six-weeks postpartum consultation, including the Edinburgh postnatal depression scale (EPDS) scores, the measurement results for diastasis recti abdominis, and the international physical activity questionnaire (long form) (IPAQ-L) scores. Logistic regression models were used to examine the effect of the PPR program on PPD among the local population. The secondary aim of this study was to investigate possible influencing factors for PPD, such as coronavirus disease 2019 (COVID-19), physical exercises, etc.
Results
PPR program has shown a clearly positive effect in preventing PPD (p < 0.001) and diastasis recti prevalence (p < 0.001) during the six-weeks postnatal control in Qingdao, China. Better post-pregnancy weight reduction (p = 0.04) and higher metabolic equivalent of task (MET) value (p < 0.001) were noticed in the non-PPR group. Furthermore, lower PPD risk was associated with longer relationship duration years (2–5 years) (p = 0.04) and exercising one to three times a week (p = 0.01). A higher PPD risk was related to urinary incontinence during the postpartum period (p = 0.04) and subjective insomnia (p < 0.001). No significant effect was shown between COVID-19 and the EPDS score in this study (p = 0.50).
Conclusion
Our results suggested that the PPR program provided protection against PPD and diastasis recti during the first six weeks after delivery. Urinary incontinence and subjective insomnia were risk factors for PPD, while longer relationship duration years and exercising one to three times a week gave protective effects to PPD. This study emphasized that a comprehensive ongoing medical care program, such as the PPR program, effectively improves women’s mental and physical health in the early postpartum in China.
Evaluation of two terpene-derived polymers as consolidants for archaeological wood
Authors: Cutajar Michelle , Braovac Susan , Stockman Robert A. , Howdle Steven M. , Harding Stephen E. 
Published: November 2022

Abstract
The evaluation of two terpene-derived polymers, termed TPA6 and TPA7, as possible consolidants for archaeological wood was carried out. The overall objective of this work was to expand the non-aqueous treatment toolkit which is available for the conservation of the highly degraded Oseberg collection. The wood artefacts which were found on the Oseberg ship were treated with alum in the early 20th century, leading to the formation of sulfuric acid and to the precarious state that they are in today. Some of these artefacts cannot be treated with conventional aqueous consolidants, like polyethylene glycol, due to their highly degraded and/or reconstructed nature. This study sought to examine the level of penetration of the polymers in archaeological wood and to evaluate their consolidative effect. Both TPA6 and TPA7 were soluble in isopropanol and had a Mw of 3.9 and 4.2 kDa respectively. A number of archaeological wood specimens were immersed in solutions of these polymers. Their penetration and effects were evaluated using weight and dimensional change, colour change, infrared spectroscopy, scanning electron microscopy and hardness tests. Both polymers successfully penetrated the wood specimens, with a higher concentration found on the surface versus the core. Additionally, both polymers appeared to increase the hardness of the specimen surfaces. Increasing the polymer concentration and soaking time in future investigations could potentially facilitate the penetration to the wood cores.
Evaluation of MHPSS Hotline Data to Enhance its Services during COVID-19 Pandemic in Egypt
Authors: Ali Nemat , Noby Sally I. , Othman Mohamed , Wahdan Maha M. , Nagar zeinab El , Ibrahim Dalia I. , Maksod Menan Abd El 
Published: November 2022

Abstract
Counseling and psychological support services were influenced by the pandemic. To reach those who seek mental health services, the General Secretary of Mental Health and Addiction Treatment (GSMHAT) has devised a strategy plan and approaches that have been placed in a timetable (2015-2016) and sent to hospital administrators and departments. The objectives of Hotline are to evaluate the national hotline for psychosocial assistance during the COVID-19 pandemic, identify concerns with data collection, and offer stakeholders with a comprehensive hotline profile that identifies improvements and obstacles. This Review intends to illustrate the significance of internet technology to the Egyptian public-health response to the COVID-19 epidemic in terms of mental health problem management. This assessment demonstrates how our nation maintains alignment with international strategies for the regulation, evaluation, and application of digital technology to boost pandemic management and future preparedness for COVID-19 and other infectious illnesses.
Numerical study on the evolution of reservoir pressure and CBM concentration considering hydraulic fractures
Authors: Wang Yuan , Zhong Liguo , Zhang Lei , Zou Junpeng 
Published: November 2022

Abstract
Based on the theories of mass conservation and coalbed methane (CBM) adsorption/desorption, a novel reservoir pressure model for CBM production is derived first. Followed by which, the CBM concentration and production models are also proposed. Then, these models are programmed and solved by means of the finite element method. Taking the Hunchun CBM field in Jilin province, China as an example, the reservoir pressure, gas concentration and production characteristics under different hydraulic fracture forms are simulated and investigated. The reservoir pressure decreases very rapidly in a small region near the fracture tip, which we called the “reservoir pressure singularity”. The existence of a hydraulic fracture greatly reduces the reservoir pressure in the process of CBM exploitation. The permeability sensitivity coefficient of reservoir pressure Rpk is defined to quantitatively describe the influence of coal seam permeability on the evolution of reservoir pressure. Rpk decreases logarithmically as the distance from CBM extraction well increases. The reservoir pressure and CBM recovery rate characteristics in the presence of multiple hydraulic fractures are also investigated. We believe these results could contribute to the design of hydraulic fracturing wells and the evaluation of gas production in a CBM reservoir.
The Social Cost of Fossil and Industrial CO2 Emissions from 1950 to 2018
Authors: Rickels Wilfried , Meier Felix , Quaas Martin 
Published: November 2022

Abstract
Past CO2 emissions cause cost and reduce wealth in the future. The present value of these costs measure the wealth borrowing from the future and countries differ considerably in their share and time profile of past CO2 emissions. Here we calibrate an integrated assessment model to data on past economic and climate development to estimate the social costs of carbon (SCC) to assess country-specific climate wealth borrowing by fossil and industrial-process CO2 emissions from 1950 to 2018. While
historical SCC have been fairly low, they were not zero, reflecting the long-lasting impact of CO2 emissions on wealth. The USA and China are responsible for almost 40 percent of climate-wealth borrowing since 1950: the US share is 25.3 (SD:1.9) and 23.5 (SD:1.1) percent, China’s share is 12.4 (SD:1.1) and 15.1(SD:1.50) percent for the calibrated and expert-based specification of the social-discount rate, respectively.
Association of kidney function and major adverse cardiovascular events in 470,453 elderly: insights from a community-based cohort study in China
Authors: Wang Chun , Huang Huijie , Lyu Yuanjun , Li Xia , Wang Xiaomeng , Chang Qinxue , Wang Keyun , Liu Yin , Gao Jing , Cui Zhuang , Li Changping 
Published: November 2022

Abstract
Background: Data are sparse regarding the association between kidney function and major adverse cardiovascular events (MACE) among older adults.
Methods: Within the Tianjin community residents Health Promotion Prospective Study, 470,453 participants without MACE were followed-up from 2014 to 2021. MACE was ascertained as the composite of nonfatal myocardial infarction (MI), nonfatal stroke or cardiovascular disease (CVD) death. The eGFR was calculated by serum creatinine (SCr) with formula at baseline and classified into four strata (< 30, 30-59, 60-89, ≥ 90 mL/min/1.73m2). BP was measured annually and systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg was defined as BP poor-control. Data were analyzed using Cox model regression and mediation analysis.
Results: During the follow-up, 50,403 participants (mean age = 67.95 ± 6.68 years, 54.90% female) developed incident MACE. Compared to ≥ 90 mL/min/1.73m2 eGFR, the multi-adjusted hazards ratio (95% CI) for < 30 mL/min/1.73m2 eGFR was 3.403 (3.014 to 3.842) of MACE, the multi-adjusted HR (95% CI) for the 30-59 mL/min/1.73m2 eGFR was 1.393 (1.250 to 1.551) of MI, the multi-adjusted HR (95% CI) for 30-59 mL/min/1.73m2 eGFR was 1.227 (1.141 to 1.320) of stroke, the multi-adjusted HR (95% CI) for < 30 mL/min/1.73m2 eGFR was 4.134 (3.647 to 4.687) of CVD death. The association between eGFR and MACE was 17.57% mediated by BP poor-control.
Conclusions: Poor kidney function was associated with increased risk of MACE and may be partially mediated by poorly control of BP among older adults.
Research on the community electric carbon emission prediction considering the dynamic emission coefficient of power system
Authors: Yu Hui , Yang Yang , Li Bin , Liu Bowen , Guo Yuanhu , Wang Yunqi , Guo Zhongfu , Meng Ronghua 
Published: November 2022

Abstract

Based on the counted power system emission factors of North China Power Grid(NCPG), a community carbon emissions sample database is constructed. The support vector regression (SVR) model is trained to forecast the power carbon emissions, which is optimized by genetic algorithm(GA). A community carbon emission warning system is designed according the results. The dynamic emission coefficient curve of the power system is obtained by fitting the annual carbon emission coefficients of NCPG. The time series SVR carbon emission prediction model is constructed and the GA are improved to optimize its parameters. Taking Beijing Caochang Community as an example, a carbon emission sample database is generated based on the electricity consumption and emission coefficient curve to training and testing the SVR model. The results show that the GA-SVR model fits well with the training set and the testing set, and the prediction accuracy of the testing set reaches 86%. In view of the training model in this paper, the carbon emission trend of community electricity consumption in the next month is predicted. The carbon emission warning system of the community is designed, and the specific strategy of community carbon emission reduction is proposed.