bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptom Experience of Cancer-related Cognitive Impairment in Women with Ovarian Cancer
Authors: wang liying , Ding Yan , Zhang Yi , Xue Mei , Lu Zhenqi , Zhang Xiaoju 
Published: March 2022

Abstract
Purpose: To explore ovarian cancer survivors’ symptom experience of cancer-related cognitive impairment (CRCI). Methods: Semi-structured interviews were conducted with eligible ovarian cancer patients in Cancer Center of Fudan University, Shanghai, China. This study was guided by symptom management theory. Qualitative content analysis and thematic framework analysis were used to refine themes.Results: The average age of participants (n=34) was 51.38 years （range 25-65 years）and median time since diagnosis was one year（range 0.2-42.8 years）.Three themes and nine subthemes were identified from the research. For perception of cognitive changes: Become stupid, not as smart as before; not noticing/ having the chance to notice any cognitive change. Possible influence events in the evaluation of CRCI: comfortable, monotonous, isolation and narrow-focused life cause the brain to "retire”; surgical anesthesia, chemotherapy as well as fatigue, sleep disorders and anxiety were also blamed for the change. For the impact of CRCI in the evaluation of cognitive changes: it was not an issue for most participants and they didn’t particularly care, only a few said that their self-confidence was affected a little. For responses to cognitive decline: Trying not burden brain, actively or passively let themselves “slow down" or "offload" things. Personalized and repeated "note", "check" and "confirm" measures to prevent mistakesConclusion: The majority of ovarian cancer patients experienced symptoms of CRCI, highlighted by memory and attention problems, however most patients stated that cognitive symptoms didn’t affect their lives. Sociocultural and cancer copying style played an important role in the CRCI symptom experience.
The Intensity of the Interaction Between Native and Non-native Antarctic Plants Depends on the Non-native Plant, Water Availability and Temperature.
Authors: Cuba-Díaz Marely , Fuentes-Lillo Eduardo , Chwedorzewska Katarzyna J. 
Published: March 2022

Abstract
Anthropogenic pressure and climate change have generated important changes in the environmental conditions of Antarctic ecosystems (e.g., arrival of non-native species, increase in temperature, precipitation, and ice-free areas), which can generate negative impacts on the native flora. Thus, we evaluated how the presence of the non-native plants Poa annua and Juncus bufonius could impact the native species Colobanthus quitensis and Deschampsia antarctica under climate change scenarios. Individuals of C quitensis/D. antarctica and J. bufonius/P. annua were subjected to four growth conditions: 6°C/low water availability (LW); 8°C/LW and 6°C/high water availability (HW) and 8°C/HW. We hypothesize that competition will be more intense at 8°C/HW, while at 6°C/LW the predominant interaction will be facilitation. Under 8°C/HW conditions all species significantly increase biomass production, but mortality of native species tends to increase. The relative interaction index (RII) showed a competitive effect of both non-native species on D. antarctica, independent of temperature and water availability, while for C. quitensis competition is more intense at LW. These results show that the effect of climate change could enhance the impact of non-native species on native species in Antarctic ecosystems, including non-native species that have been reported but do not have stable populations in the Antarctic Peninsula.
Association Between Serum 25-hydroxy-vitamin D Level, Liver Function and Liver Fibrosis in Biliary Atresia Infants One Year After Kasai Procedure
Authors: Wu Xiaoxia , Ren Hongxia , Zhang Hui , Baohong Zhao , Jin Yuanyuan , Liu Wenyue , Zhao Liang , Sun Xue , Guo Xin , Li Wei 
Published: March 2022

Abstract
Objective: To investigate the relationship between serum 25 (OH) D level, liver function, and liver fibrosis in infants with in biliary atresia (BA) infants one year after Kasai procedure. Methods: This retrospective study was conducted using the clinical data of children with BA confirmed by cholangiography and/or surgery admitted to Children Hospital of Shanxi Province between October 2018 and October 2020, as well as the follow-up data at 1, 3, 6, and 12 months after Kasai Portoenterotomy so as to analyze the relationship between serum 25(OH) D level, liver function, and liver fibrosis. Results: Preoperative data of 57 infants with BA were collected. All infants had vitamin D insufficiency or deficiency status before surgery. Three months after surgery, data were collected from 55 infants, 15 of whom did not take vitamin D supplements and 40 of whom received regular vitamin D supplementation. It was found that 15.38%, 47.22%, 75%, and 92.31% of infants living with regular vitamin D supplementation and native liver had sufficient vitamin D levels at 3, 6, and 12 months after Kasai surgery, respectively. The serum 25(OH) D level was significantly lower in patients without vitamin D supplements at 3 months after surgery (t=-2.974，P＜0.05), and the aspartate aminotransferase to platelet ratio index (APRI) was higher in patients with vitamin D supplementation. There was no significant correlation between vitamin D level, liver function, and liver fibrosis preoperatively (P＞0.05). The level of serum 25(OH) D was negatively correlated with liver fibrosis and liver function in infants with the native liver at 12 months after surgery (P < 0.05).Conclusion: Vitamin D deficiency was commonly found in children with BA before operation. Nearly 70% of infants living with native liver reached sufficient vitamin D levels within 6 months after surgery with routine vitamin D supplementation. Serum 25 (OH)D level can reflect the degree of liver fibrosis and liver function in biliary atresia infants living with the native liver at 12 months after the Kasai procedure.
CALN1 Hypomethylation As A Biomarker For High-Risk Bladder Cancer
Authors: Takagi Kimiaki , Naruse Azumi , Akita Kazutoshi , Muramatsu-Maekawa Yuka , Kawase Kota , Koie Takuya , Horie Masanobu , Kikuchi Arizumi 
Published: March 2022

Abstract
Background: DNA methylation in cancer is considered a diagnostic and predictive biomarker. We investigated the usefulness of the methylation status of CALN1 as a biomarker for bladder cancer using methylation-sensitive restriction enzyme (MSRE)-quantitative polymerase chain reaction (qPCR).Methods: A total of 82 bladder cancer fresh samples were collected via transurethral resection of bladder tumors. Genomic DNA was extracted from samples, and MSRE-qPCR was performed to determine the CALN1 methylation percentage. Reverse transcription-qPCR was performed to assess the correlation between CALN1 methylation and mRNA expression. The association between CALN1 methylation percentage and clinicopathological variables of all cases and intravesical recurrence of non-muscle-invasive bladder cancer (non-MIBC) cases were analyzed.Results: Of the 82 cases, nine were MIBC cases and 71 were non-MIBC cases that had not undergone total cystectomy. The median CALN1 methylation percentage was 79.5% (interquartile range: 51.1, 92.6). CALN1 gene methylation percentage had a negative relationship with CALN1 mRNA expression (Spearman’s ρ = -0.563 and P = 0.0121). Hypomethylation of CALN1 was associated with advanced tumor stage (P = 0.0007) and histologically high grade (P = 0.0178). Furthermore, multivariate analysis revealed that CALN1 hypomethylation was an independent risk factor for intravesical recurrence in non-MIBC patients (hazard ratio 3.83, 95% confidence interval; 1.14–13.0, P = 0.0305). Conclusion: Our findings suggest that CALN1 methylation percentage could be a useful molecular biomarker in bladder cancer patients.
Preparation and characterization of a new alkali-activated binder for superfine-tailings mine backfill
Authors: Sun Yong , Zhao Yingliang , Qiu Jingping , Zhang Shiyu , Sun Xiaogang , Gu Xiaowei 
Published: March 2022

Abstract
Recently, the increasing of ultrafine-tailings increases the amount of ordinary Portland cement (OPC) in cemented paste backfill (CPB), which leads to the rise of CPB cost and carbon emission. Alternative binders should be then developed. The present work focuses on the preparation of binder using slag activated by a mixture of calcined quarry dust (CQD, mainly consists of reactive CaO and MgO) and NaOH at a mass ratio of 1:1 with contents ranging from 6 % to 10 % up to 90 d. The results indicated that CQD/NaOH was more effective than using NaOH or CQD alone in activating slag and also showed better performance than OPC. The compressive strength of the CPB samples using 10 % CQD/NaOH was around 3.78 MPa after curing for 90d, around 42 % higher than the OPC-based CPB samples. The reaction products of CQD/NaOH activated slag consisted mainly of C-(A)-S-H, Ht phases, and M-S-H. The generation of Ht phases lowered the Al incorporation into the structure of C-S-H, resulting in lower average Al/Si ratio and mean chain length.
Optimal Time for Bile Duct Injury Reconstruction. Early Does Not Mean Better: a Multicenter Retrospective Analysis of a Hepato-pancreatic-biliary Group
Authors: Chaves Carlos Eduardo Rey , Monroy Danny Conde , Gómez P. Torres , Recamán Andrea , Pardo Manuel , Sabogal JC 
Published: March 2022

Abstract
Background Common bile duct injury it’s a severe and complex complication, and it’s related to increased rates of morbidity and mortality. Early recognition and on-time diagnosis plus multidisciplinary management led by a hepatobiliary surgeon show fewer complications rate and best postoperative outcomes. No guideline exists among the proper time of reconstruction. This study aims to describe the experience of a specialized Hepato-Pancreatic-Biliary (HPB) group and to analyze the outcomes regarding the time of bile duct injury (BDI) repair. MethodsA multicenter retrospective review of a prospectively collected database was conducted. All the patients older than 18 years old that underwent common bile duct reconstruction between January 2014 – December 2020 were included. Analysis and description of preoperative characteristics and postoperative outcomes were performed. A reconstruction time-based group differentiation was made and analyzed. Results 37 patients underwent common bile duct reconstruction between January 2014 and December 2020. 62.16% of the patients were female. The mean age was 50.4 years +/- 19.5 years. The most common injury was type E3 (29.73%). Hepaticojejunostomy was performed in 75.68% of the patients. Delayed reconstruction (> 72 hours) was performed in the majority of the cases (81.08%) due to delays in the referral centers. No statistically significant difference regarding complications in early or delayed BDI reconstruction. The mortality rate was 2.7% (n=1). 2-year follow-up bilioenteric stenosis was observed in 7 patients. Biloma showed a statistical relationship with complex bile duct injuries (p=0.02). Conclusion Common bile duct injury remains to be a concerning complication in general surgery. The multidisciplinary approach shows a lesser complication rate. The time of BDI reconstruction seems not to be a significant factor related to complications. In this study, biloma was associated with complex bile duct injury, However, further studies are needed to confirm our results.
Effect of cognitive behavior therapy based on the health education pathway on psychology of Chinese papillary thyroid carcinoma patients: A randomized controlled trial
Authors: Jia Zhiyun , Zhao Chunyan , Diao Wei , Xu Xin , Li Lin 
Published: March 2022

Abstract
Purpose: Our main aim was to explore whether cognitive behavior therapy based on the health education pathway (CBT-HEP) can effectively alleviate the psychological problems of papillary thyroid carcinoma (PTC) patients after 131I treatment.Methods: Eligible PTC patients were prospectively included (July 1, 2019-February 1, 2021). The baseline demographic characteristics questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), the Distress Thermometer (DT), the Hamilton Anxiety Scale (HAMA), and the Patient Health Questionnaire-9 (PHQ-9)needed to be completed. Patients with a DT score ≥ 4 were randomly enrolled in further intervention trials. Patients received CBT-HEP and casual conversation (CC) in different groups.Results: A total of 357 PTC patients were investigated in this study, 48 and 49 patients were included in the CBT-HEP and CC groups, respectively. The DT, HAMA, and PHQ-9 scores before and after intervention and after six months of follow-up were 5.19, 10.29, 5.60; 2.50, 5.44, 3.38; 1.67, 3.98, 2.79 (CBT-HEP) and 4.84, 8.16, 3.76; 4.39, 8.53, 4.63; 3.63, 8.14, 4.37 (CC), respectively. DT, HAMA, and PHQ-9 scores decreased more significantly in the CBT-HEP group. Women, living alone, hypothyroidism, sadness, anxiety, tingling in hands/feet, breathing, concern about the treatment effect and radiation safety significantly increased the likelihood of a severe DT score.Conclusion: CBT-HEP is effective in relieving distress, anxiety and depression in PTC patients. In addition, PTC patients with the above characteristics have a poorer quality of life and should receive more attention.Registration: ChiCTR1900025852; registration date, September 11, 2019
Correlation Between Self-management Efficacy and Supportive Care Needs Among Patients With Breast Cancer Receiving Chemotherapy
Authors: Huang Yanwei , Li Xiaoxu , Cai Jiyu , Zhou Fang , Song Jingyuan 
Published: March 2022

Abstract
Aim: To investigate the status and relationship of supportive care needs and self-management efficacy in patients with breast cancer receiving chemotherapy.Methods: Patients with breast cancer (N=160) receiving chemotherapy were selected through convenience sampling. The general information questionnaire, 34-Item Short-Form Supportive Care Needs Survey scale, and Chinese version of Strategies Used by People to Promote Health scale were used. Results: The total supportive care needs and overall self-management efficacy scale scores were (2.80±0.46) points and (91.71±12.16) points, respectively. Spearman correlation analysis showed that the total score of self-management efficacy and those of each dimension were negatively correlated with the total score of supportive care needs and those of each dimension (P<0.05). Hierarchical regression analysis identified self-management efficacy as the main influencing factor of supportive care needs in these patients (P<0.05). Conclusions：Supportive care needs of patients with breast cancer receiving chemotherapy is at the higher level. Medical staff should improve the self-management efficacy of patients to meet these needs.
Comparison Of Physical Activity And Sedentary Behavior In Autologous And Allogeneic Hematopoietic Stem Cell Transplantation Survivors
Authors: Nakagami Takayuki , Tawara Yuichi , Shinya Junko , Naito Kensuke 
Published: March 2022

Abstract
Purpose: The treatment background, as well as the frequency and type of complications, in autologous (auto-) and allogeneic (allo-) hematopoietic stem cell transplantation (HSCT) survivors influence the appearance of moderate to vigorous physical activity (MVPA) or sedentary behavior. We aimed to identify differences in MVPA and sedentary behavior between auto- and allo-HSCT survivors. Methods: We included 13 auto- and 36 allo-HSCT survivors (≈ 4 years after HSCT). MVPA and sedentary behavior were assessed using a triaxial accelerometer.Results: There were no significant between-group differences in MVPA and sedentary behavior (p = 0.768 and 0.739, respectively). In allo-HSCT survivors, MVPA was negatively correlated with the Hospital Anxiety and Depression Scale score (r = -0.358, p = 0.032). Stepwise multiple regression analysis showed that age was a significant predictor of sedentary behavior in allo-HSCT survivors (β = 0.400, p = 0.016). Conclusion: We observed no significant between-group differences in MVPA and sedentary behavior. Our results suggest that it may be unnecessary to change the rehabilitation program according to the donor type in interventions for promoting MVPA and reducing sedentary behavior in long-term HSCT survivors.
Characteristics Of Monolithic Multisection Distributed-Bragg-Reflector Master-Oscillator Power-Amplifiers
Authors: Tronciu Vasile , Grigoriev Eugeniu , Zink Christof , Wenzel Hans 
Published: March 2022

Abstract
We report theoretical results on the wavelength stability of a multisection master-oscillator power-amplifier emitting at 1064 nm. We use a traveling wave equation model to calculate the optical output power and spectral maps versus the currents injected into the different sections of the device. The numerical model explains quantitatively the experimental findings, particularly the collapse of the power if the current injected into a control section adjacent to the distributed Bragg reflector laser acting as master oscillator exceeds certain values. We investigate the influence of the reflectivity at the facet of the power amplifier on the laser behavior.
Phase II Trial of Metronomic Capecitabine and Cyclophosphamide with Lapatinib and Trastuzumab in Patients with HER2 Positive Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab- Based Regimen
Authors: Kang Irene , Zang Peter D. , Spicer Darcy V. , Lu Janice M. , Groshen Susan , Tsao-Wei Denice , Garcia Augustin A. 
Published: March 2022

Abstract
Background:Breast cancer is the most common cancer and second most common cause of cancer mortality in women. Around 25% of all breast cancers have overexpression of Human Epidermal growth factor 2 (HER2), which is associated with earlier recurrence and shorter overall survival. ‘Metronomic chemotherapy’ is an emerging paradigm in cancer therapy, in which frequent low doses of chemotherapeutic agents are administered at frequent intervals. We proposed a regimen with metronomic chemotherapy with dual HER2 inhibition in HER2 positive patients with MBC. We hypothesize that this regimen will be highly active in MBC and have a favorable toxicity profile.Methods:This was a single-center, phase II, single arm, open-label study. Female patients 18 years of age and older who had histologically confirmed HER2-positive metastatic breast cancer with prior trastuzumab use in the adjuvant or metastatic setting were eligible. Patients were treated on a 21-day cycle with capecitabine 1500mg PO daily, cyclophosphamide 50mg PO daily, lapatinib 1000mg PO daily and trastuzumab 6mg/kg IV once per 21-day cycle. The primary objective of this study was to estimate the progression free survival (PFS). Secondary objectives were to evaluate the overall response rate (ORR), to evaluate the clinical benefit rate (CBR; complete response, partial response, and stable disease for ≥24 weeks), to estimate the overall survival (OS) and to assess the safety and tolerability of this regimen in the study population. Results:Ten patients were accrued for the study. PFS was 13.7 (95% CI: 2.6, 16.6) months. ORR was 40% (95% CI: 15%, 70%), and CBR was 70%. Median OS was 29.6 (95% CI: 11.8, 81.9+) months. Several grade 3 toxicities were identified in 5 patients (50%): diarrhea, weight loss, fatigue, infusion related reaction, abdominal pain, oral mucositis, paronychia, AST and ALT increase, neutropenia, leukopenia and palmar-plantar erythrodysesthesia.Conclusions:The proposed regimen of metronomic capecitabine and cyclophosphamide with lapatinib and trastuzumab appears to be active in patients with HER2 positive MBC but with toxicity in line with other standard therapies. Trial Registration: ClinicalTrials.gov # NCT01873833 Date: June 10, 2013
A Predictive Model for Student Performance in Classrooms Using Student Interactions With an eTextbook
Authors: AbdElrahman Ahmed , Soliman Taysir Hassan A , Taloba Ahmed I. , Farghally Mohammed F. 
Published: March 2022

Abstract
With the rise of online eTextbooks and Massive Open Online Courses (MOOCs), a huge amount of data has been collected related to students’ learning. With the careful analysis of this data, educators can gain useful insights into the performance of their students and their behavior in learning a particular topic. This paper proposes a new model for predicting student performance based on an analysis of how students interact with an interactive online eTextbook. By being able to predict students’ performance early in the course, educators can easily identify students at risk and provide a suitable intervention. We considered two main issues the prediction of good/bad performance and the prediction of the final exam grade. To build the proposed model, we evaluated the most popular classification and regression algorithms on data from a data structures and algorithms course (CS2) offered in a large public research university. Random Forest Regression and Multiple Linear Regression have been applied in Regression. While Logistic Regression, decision tree, Random Forest Classifier, K Nearest Neighbors, and Support Vector Machine have been applied in classification. Based on the findings of the experiments, the algorithm with the best result overall in classification for this data was Random Forest Classifier with an accuracy equal to 91.7% while in the regression it was Random Forest Regression with an R² equal to 0.977.
Exploring the Potential of Microalgae Bioalcohol and Biodiesel in Arresting Particulate Smoke Emissions and Greenhouse Gases using Post-Injection Activated Regeneration Trap
Authors: Jacob Ashwin , Ashok Bragadeshwaran , Lawrence Jino , Soosairaj Arockia Suthan , Anandan Jayaganthan , Elango Manoj 
Published: March 2022

Abstract
The rapid deterioration of the atmospheric air quality due to the rise in vehicular emissions is a cause for concern in a global scale. Hence, it is crucial to establish efficient control measures to mitigate these crises. In this context, the objective of this study is to explore the effect of post injection parameters on a continuous active regeneration trap (CART) to mitigate harmful greenhouse gases (GHG) and particulate smoke emissions (PSE) using diesel fuel reformulated by long-chain microalgae bio-alcohol and low – density microalgae biodiesel. Furthermore, the efficiency of the CART unit is analyzed based on its ability to mitigate the harmful emissions without sacrificing the engine performance characteristics. From the study, it was observed that the maximum de-smoke efficiency of 67.85% is observed at a post injection timing (PIT) of 20°CA aTDC at a post injection mass (PIM) of 4 mg for low load condition while operating on microalgae biodiesel. While operating on microalgae bio-alcohol, the maximum de-smoke CART efficiency was observed as 67.25% and 55.78% for low and medium load conditions at a PIT and PIM of 20°CA aTDC and 2 mg while operating on the microalgae bio-alcohol. Likewise, the maximum de-HC CART efficiency was obtained at a PIT and PIM of 10°CA aTDC and 1 mg with a reduction of about 75% and 73.8% for medium and high load conditions. A slight reduction in oxides of nitrogen with the complete elimination of carbon monoxide emissions is observed after CART treatment for both the fuels.