bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcapsular renal haematoma after ureteroscopic lithotripsy: a single-centre, retrospective study in China
Authors: Yu Jiang , Li Bin , Ren Bin Xiang , Zhang Nan Yi , Jin Bo Xun , Zhang Jun Jian 
Published: November 2022

ObjectivesTo investigate the incidence, predisposing factors, diagnosis and management of subcapsular renal haematoma (SRH) after ureteroscopic lithotripsy (URSL).DesignRetrospective observational study.SettingShandong Provincial Hospital, a 4500-bed tertiary hospital in China.ParticipantsThe data from 1535 consecutive patients treated with URSL (including rigid URSL and flexible URSL) between January 2015 and October 2020 were retrospectively analysed.Main outcome measuresSRH after URSL confirmed via CT. The characteristics, operative data and outcomes of these patients were documented and compared.ResultsSix patients were confirmed to have an SRH after URSL on CT. The total incidence of SRH after URSL was 0.39%. The incidences of SRH after rigid URSL and flexible URSL were 0.38% and 0.41%, respectively. Unendurable ipsilateral flank pain and a significant decrease in haemoglobin after surgery were the typical clinical manifestations of SRH after URSL. There were no significant differences in age, sex, history of diabetes mellitus, preoperative hypertension, body mass index, stone laterality or perfusion pressure (p>0.05). However, SRH was significantly associated with the stone size, stone location, degree of hydronephrosis and operative duration (p<0.01). One patient was managed conservatively without further intervention, percutaneous drainage was performed in four patients and one patient underwent emergency angiography. No patients died of SRH.ConclusionsSRH is a rare but potentially serious complication of URSL. Severe hydronephrosis and a thin renal cortex preoperatively and prolonged operative duration are strong predisposing factors for SRH. Laparoscopic ureterolithotomy should be considered as an alternative surgery for patients with severe ureteral tortuosity. SRH is treated based on patients’ clinical manifestations. Most patients can be managed with conservative treatment or percutaneous drainage alone.
Evaluation of emotion-centric psychological interventions for chronic pain: protocol for a systematic review and meta-analysis
Authors: Norman-Nott Nell , Hesam-Shariati Negin , Cashin Aidan G , Wewege Michael A , Rizzo Rodrigo RN , Wilks Chelsey R , Quidé Yann , McAuley James , Gustin Sylvia Maria 
Published: November 2022

IntroductionChronic pain, defined as pain persisting longer than 3 months, is more than an unpleasant sensory experience. Persistent negative emotions and emotional comorbidities, such as depression and anxiety, plague people with chronic pain leading to worsening pain intensity and increasing disability. While cognitive–behavioural therapy (CBT) is the gold standard psychological treatment, recent evidence highlights that CBT lacks efficacy for the physical and emotional aspects of chronic pain. Increasingly, researchers are investigating emotion-centric psychological therapies. While treatment modalities vary, these interventions frequently target understanding emotions, and train individuals for an emotionally adaptive response. The aim of this systematic review and meta-analysis is to quantify the efficacy of emotion-centric interventions for the physical and emotional characteristics of chronic pain.Methods/analysisElectronic databases (EMBASE, PubMed, PsychINFO, Cochrane Central Register of Controlled Trials, CINAHL and Web of Science) will be systematically searched from inception to 28 April 2022 for randomised controlled trials. Studies that compare an emotion-centric intervention with another form of treatment or placebo/control for adults (≥18 years old) with chronic pain will be included. All treatment modes (eg, online or in-person), any duration and group-based or individual treatments will be included. Studies that do not investigate at least one emotion-centric treatment will be excluded. The primary outcome is pain intensity. Secondary outcomes include emotion dysregulation, depression, anxiety, affect, safety and intervention compliance. A quantitative synthesis using a random effects meta-analysis will be adopted. Risk of bias will be evaluated using Cochrane Risk of Bias V.2.0 with the certainty of evidence assessed according to Recommendation, Assessment, Development and Evaluation. Data permitting, subgroup analysis will be conducted for intervention type and pain condition.Ethics and disseminationEthical approval is not required for this systematic review. Results may inform an efficacy study examining a new emotion-centric intervention for chronic pain. Dissemination will be through peer-reviewed publications and in conference presentations.PROSPERO registration numberCRD42021266815.
Efficacy and safety of remifentanil dose titration to correct the spontaneous hyperventilation in aneurysmal subarachnoid haemorrhage: protocol and statistical analysis for a prospective physiological study
Authors: Su Rui , Zhou Jianfang , Zhu Ning , Chen Xiaolin , Zhou Jian-Xin , Li Hong-Liang 
Published: November 2022

IntroductionSpontaneous hyperventilation (SHV) is common in aneurysmal subarachnoid haemorrhage (aSAH). The reduction in arterial partial pressure of carbon dioxide (PaCO2) may change the brain physiology, such as haemodynamics, oxygenation, metabolism and may lead to secondary brain injury. However, how to correct SHV safely and effectively in patients with aSAH has not been well investigated. The aim of this study is to investigate the efficacy and safety of remifentanil dose titration to correct hyperventilation in aSAH, as well as the effect of changes in PaCO2on cerebral blood flow (CBF).Methods and analysisThis study is a prospective, single-centre, physiological study in patients with aSAH. The patients who were mechanically ventilated and who meet with SHV (tachypnoea combined with PaCO2<35 mm Hg and pH >7.45) will be enrolled. The remifentanil will be titrated to correct the SHV. The predetermined initial dose of remifentanil is 0.02 μg/kg/min and will be maintained for 30 min, and PaCO2and CBF will be measured. After that, the dose of remifentanil will be sequentially increased to 0.04, 0.06, and 0.08 μg/kg/min, and the measurements for PaCO2and CBF will be repeated 30 min after each dose adjustment and will be compared with their baseline values.Ethics and disseminationThis study has been approved by the Institutional Review Board of Beijing Tiantan Hospital, Capital Medical University (KY 2021-006-02) and has been registered at ClinicalTrials.gov. The results of this study will be disseminated through peer-reviewed publications and conference presentations.Trial registration numberNCT04940273.
Women’s preference to apply shared decision-making in breast cancer screening: a discrete choice experiment
Authors: Hernández-Leal María José , Pérez-Lacasta María José , Cardona-Cardona Angels , Codern-Bové Núria , Vidal-Lancis Carmen , Rue Montserrat , Forné Carles , Carles-Lavila Misericòrdia 
Published: November 2022

ObjectiveTo analyse women’s stated preferences for establishing the relative importance of each attribute of shared decision-making (SDM) and their willingness to pay (WTP) for more participatory care in breast cancer screening programmes (BCSP).DesignA discrete choice experiment was designed with 12 questions (choice tasks). It included three attributes: ‘How the information is obtained’, regarding benefits and harms; whether there is a ‘Dialogue for scheduled mammography’ between the healthcare professional and the woman; and, ‘Who makes the decision’, regarding participation in BCSP. Data were obtained using a survey that included 12 choice tasks, 1 question on WTP and 7 socioeconomic-related questions. The analysis was performed using conditional mixed-effect logit regression and stratification according to WTP.SettingData collection related to BCSP was conducted between June and November 2021 in Catalonia, Spain.ParticipantsSixty-five women aged between 50 and 60.Main outcome measuresWomen’s perceived utility of each attribute, trade-off on these attributes and WTP for SDM in BCSP.ResultThe only significant attribute was ‘Who makes the decision’. The decision made alone (coefficient=2.879; 95% CI=2.297 to 3.461) and the decision made together with a healthcare professional (2.375; 95% CI=1.573 to 3.177) were the options preferred by women. The former contributes 21% more utility than the latter. Moreover, 52.3% of the women stated a WTP of €10 or more for SDM. Women’s preferences regarding attributes did not influence their WTP.ConclusionsThe participant women refused a current paternalistic model and preferred either SDM or informed decision-making in BCSP.
Completion of the maternal continuum of care and its association with antenatal care attendance during previous pregnancy among women in rural areas of the Gurage Zone, Southwest Ethiopia: a community-based cross-sectional study
Authors: Tenaw Shegaw Geze , Tsega Daniel , Zewudie Bitew Tefera , Chekole Bogale , Eniyew Muche Argaw , Mesfin Yibeltal 
Published: November 2022

ObjectiveThe maternal continuum of care is a cost-effective intervention to prevent pregnancy and childbirth-related maternal and neonatal mortality and morbidity. This study aimed to investigate the prevalence of completion of the maternal continuum of care and its association with antenatal care (ANC) attendance during previous pregnancy among women in rural kebeles of Gurage Zone, Southwest Ethiopia.DesignA community-based cross-sectional study.SettingThe study took place in 12 rural kebeles of the Gurage Zone from 1 April 2022 to 12 May 2022.ParticipantsRandomly selected 497 women who gave birth in the previous 12 months in rural kebeles of the Gurage Zone.OutcomeThe outcome of this study was the prevalence of completion of the maternal continuum of care.ResultsOverall, the prevalence of completion of the maternal continuum of care was 15.5% (95% CI: 12.55% to 18.9%). After adjusting for potential confounders, having ANC attendance during a previous pregnancy (adjusted OR (AOR): 2.01; 95% CI: 1.07 to 3.76) was positively associated with the completion of the maternal continuum of care. In addition, having access to ambulance service as a means of transportation (AOR: 6.01; 95% CI: 3.16 to 11.39)andexposure to mass media (AOR: 2.43; 95% CI: 1.27 to 4.68) were positively associated with completion of the maternal continuum of care.ConclusionThe prevalence of completion of the maternity continuum of care was unacceptably low in this study. This result indicates that the women did not receive the maximum possible health benefit from existing maternal healthcare services. The completion of the maternal continuum of care was affected by ANC attendance in a previous pregnancy. Therefore, interventions that can strengthen ANC are crucial in the maternal continuum of the care pathway.
Mixed-methods implementation study of a virtual culturally tailored diabetes self-management programme for African and Caribbean communities (HEAL-D) in south London and its scaling up across NHS regions in England: study protocol
Authors: Lowry Sophie , Goff Louise , Irwin Sally , Brady Oliver , Curran Natasha , Lelliott Zoe , Sevdalis Nick , Walker Andrew 
Published: November 2022

IntroductionThe National Health Service Insight Prioritisation Programme was established to accelerate the implementation and evaluation of innovation that supports post-pandemic working. Supporting this, the Academic Health Science Network and National Institute for Health and Care Research Applied Research Collaboration in South London are testing and evaluating the implementation and scale-up of a type 2 diabetes (T2D) intervention.T2D is estimated to be three times more prevalent in UK African and Caribbean communities than in white Europeans. To tackle ethnic inequities in T2D healthcare access, an evidence-based, culturally tailored self-management and education programme for African and Caribbean adults (Healthy Eating & Active Lifestyles for Diabetes, HEAL-D) has been codeveloped with people with lived experience. Initially a face-to-face programme, HEAL-D pivoted to virtual delivery in response to COVID-19.The purpose of this study is to explore the (1) feasibility and acceptability of a virtual delivery model for HEAL-D in south London and (2) factors affecting its scale-up across other areas in England.Methods and analysisThe study will have two strands: (1) mixed-methods prospective evaluation of HEAL-D virtual delivery in south London using routinely collected service-level data, service delivery staff and service user interviews and observations; and (2) prospective qualitative study of the scale-up of this virtual delivery comprising interviews and focus groups with members of the public, and diabetes services commissioners and providers across England. Qualitative data will be analysed using thematic analysis. Quantitative analysis will use descriptive statistics and reporting summary tables and figures. The study will be grounded in well-established implementation frameworks and service user involvement.Ethics and dissemination‘Minimal Risk Registration’ ethical clearance was granted by King’s College London’s Research Ethics Office (ref: MRA-21/22-28498). Results will be published in a peer-reviewed journal and summaries provided to the study funders and participants.
Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility study investigating toxicity outcomes following reirradiation with stereotactic body radiotherapy (SBRT) versus high-dose-rate brachytherapy (HDR-BT)
Authors: Zhong Jim , Brown Sarah , Serra Maria , Shuttleworth Pam , Bownes Peter , Thompson Christopher , Reed Rachel , Reeves Kimberley , Dubec Michael , McHugh Damien , Eccles Cynthia , Chuter Robert , Tsang Yat Man , Taylor N Jane , West Catharine , Buckley David , Scarsbrook Andrew , Choudhury Ananya , Hoskin Peter , Henry Ann 
Published: November 2022

IntroductionRadiotherapy is the most common curative treatment for non-metastatic prostate cancer; however, up to 13% of patients will develop local recurrence within 10 years. Patients can undergo further and potentially curative treatment including salvage surgery, brachytherapy (BT), external beam radiotherapy, high-intensity focused ultrasound and cryotherapy. Systematic review shows that high-dose-rate (HDR) BT and stereotactic body radiotherapy (SBRT) have the best outcomes in terms of biochemical control and lowest side effects. The reirradiation options for previously irradiated prostate cancer (RO-PIP) trial aims to determine the feasibility of recruitment to a trial randomising patients to salvage HDR-BT or SBRT and provide prospective data on patient recorded toxicity outcomes that will inform a future phase III trial.Methods and analysisThe primary endpoint of the RO-PIP feasibility study is to evaluate the patient recruitment potential over 2 years to a trial randomising to either SBRT or HDR-BT for patients who develop local recurrence of prostate cancer following previous radiation therapy. The aim is to recruit 60 patients across 3 sites over 2 years and randomise 1:1 to SBRT or HDR-BT. Secondary objectives include recording clinician and patient-reported outcome measures to evaluate treatment-related toxicity. In addition, the study aims to identify potential imaging, genomic and proteomic biomarkers that are predictive of toxicity and outcome based on hypoxia status, a prognostic marker of prostate cancer.Ethics and disseminationThis study has been approved by the Yorkshire and The Humber—Bradford Leeds Research Ethics Committee (Reference: 21/YH/0305, IRAS: 297060, January 2022). The results will be presented in national and international conferences, published in peer-reviewed journals and will be communicated to relevant stakeholders. A plain English report will be shared with the study participants, patients’ organisations and media.Trial registration numberISRCTN 12238218 (Amy Ackroyd NIHR CPMS Team).
Impact of sodium-glucose cotransporter-2 inhibitors on heart failure and mortality in patients with cancer
Authors: Chiang Cho-Han , Chiang Cho-Hung , Chiang Cho-Hsien , Ma Kevin Sheng-Kai , Peng Chun-Yu , Hsia Yuan Ping , Horng Chuan-Sheng , Chen Cheng-Ying , Chang Yu-Cheng , See Xin Ya , Chen Yuan-Jen , Wang Shih-Syuan , Suero-Abreu Giselle A , Peterson LR , Thavendiranathan Paaladinesh , Armand Philippe , Peng Cheng-Ming , Shiah Her-Shyong , Neilan Tomas G 
Published: November 2022

ObjectivesSodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce heart failure (HF) in at-risk patients and may possess antitumour effects. We examined the effect of SGLT2i on HF and mortality among patients with cancer and diabetes.MethodsThis was a retrospective propensity score-matched cohort study involving adult patients with type 2 diabetes mellitus diagnosed with cancer between January 2010 and December 2021. The primary outcomes were hospitalisation for incident HF and all-cause mortality. The secondary outcomes were serious adverse events associated with SGLT2i.ResultsFrom a total of 8640 patients, 878 SGLT2i recipients were matched to non-recipients. During a median follow-up of 18.8 months, SGLT2i recipients had a threefold lower rate of hospitalisation for incident HF compared with non-SGLT2i recipients (2.92 vs 8.95 per 1000 patient-years, p=0.018). In Cox regression and competing regression models, SGLT2i were associated with a 72% reduction in the risk of hospitalisation for HF (HR 0.28 (95% CI: 0.11 to 0.77), p=0.013; subdistribution HR 0.32 (95% CI: 0.12 to 0.84), p=0.021). The use of SGLT2i was also associated with a higher overall survival (85.3% vs 63.0% at 2 years, p<0.001). The risk of serious adverse events such as hypoglycaemia and sepsis was similar between the two groups.ConclusionsThe use of SGLT2i was associated with a lower rate of incident HF and prolonged overall survival in patients with cancer with diabetes mellitus.
Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study
Authors: Shao Miao , Miao Miao , Zhang Xia , Zhang Xiaoying , An Yuan , Guo Huifang , Lei Lingyan , Zhao Qing , Ding Yanjie , Lin Jin , Wu Rui , Yu Feng , Li Yucui , Miao Huali , Zhang Liyun , Du Yan , Jiao Ruiying , Pang Lixia , Long Li , Yao Xueming , Shi Xiaofei , Wang Fei , Cui Luping , Zhang Lei , Liu Shengyun , Lu Fuai , Luo Kangkai , Zhao Simeng , Wang Yongfu , Wu Xiao , Wang Qingwen , Liu Hongjiang , Song Shulin , Zhou Xiaoyuan , Zhang Xiaoping , Shi Shumei , Zhu Hong , Chen Yao , Yu Honglian , Wu Jie , Yu Ruiyun , Fan Wenqiang , Liu Shuang , Xu Jian , Chen Zhibin , Shi Lianjie , He Jing , Zhang Xuewu , Li Zhanguo , Li Ru 
Published: November 2022

ObjectiveInfection is a major cause of death in patients with SLE. This study aimed to explore the infection rate in patients with SLE receiving a low dose of intravenous cyclophosphamide (IV-CYC).MethodsClinical parameters of 1022 patients with SLE from 24 hospitals in China were collected. Patients were divided into the short-interval and lower-dose (SILD, 400 mg every 2 weeks) IV-CYC group and the high-dose (HD, 500 mg/m2of body surface area every month) IV-CYC group. The clinical data and infection rate between the two groups were compared.ResultsCompared with HD IV-CYC, the infection rate of the SILD IV-CYC group was significantly lower (13.04% vs 22.27%, p=0.001). Respiratory tract infection (10.28% vs 15.23%, p=0.046) and skin/soft tissue infection (1.78% vs 4.3%, p=0.040) were significantly decreased in the SILD IV-CYC group. Moreover, infections occurred most likely in patients with SLE with leucopenia (OR 2.266, 95% CI 1.322 to 3.887, p=0.003), pulmonary arterial hypertension (OR 2.756, 95% CI 1.249 to 6.080, p=0.012) and >15 mg/day of glucocorticoid (OR 2.220, 95% CI 1.097 to 4.489, p=0.027).ConclusionsSILD IV-CYC showed a lower frequency of infection events than high-dose IV-CYC in patients with SLE.
Cubic interactions of d4 irreducible massless higher spin fields within BRST approach
Authors: Buchbinder I. L. , Krykhtin V. A. , Snegirev T. V. 
Published: November 2022

AbstractWe develop an approach to constructing the manifestly Lorentz covariant cubic interaction vertices for the four-dimensional massless higher spin bosonic fields with two-component dotted and undotted spinor indices. Such fields automatically satisfy the traceless conditions what simplify form of the equations determining the irreducible massless representation of the Poincaré group with given helicity. The cubic vertex is formulated in the framework of the BRST approach to higher spin field theory. Use of the above spin-tensor fields allows to simplify a form of the BRST-charge and hence to find the cubic vertices just in terms of irreducible higher spin fields. We derive an equation for the cubic vertex and find solutions for arbitrary spins $$s_1,s_2,s_3$$

s
1

,

s
2

,

s
3

with the number of derivatives $$s_1+s_2+s_3$$

s
1

+

s
2

+

s
3

in the vertex. As an example, we explicitly construct a vertex corresponding to the interaction of a higher spin field with scalars.
On the basic representation of the double affine Hecke algebra at critical level
Authors: van Diejen J. F. , Emsiz E. , Zurrián I. N. 
Published: November 2022

We construct the basic representation of the double affine Hecke algebra at critical level [Formula: see text] associated to an irreducible reduced affine root system [Formula: see text] with a reduced gradient root system. For [Formula: see text] of untwisted type such a representation was studied by Oblomkov [A. Oblomkov, Double affine Hecke algebras and Calogero–Moser spaces, Represent. Theory 8(2004) 243–266] and further detailed by Gehles [K. E. Gehles, Properties of Cherednik algebras and graded Hecke algebras, PhD thesis, University of Glasgow (2006)] in the presence of minuscule weights.
Un ascète de cour : lecture de la biographie d’Abū l-ʿAtāhiya dans le Kitāb al-Aġānī
Authors: Hoorelbeke Mathias 
Published: November 2022

Résumé
Le Kitāb al-Aġānī (Le livre des chansons) consacre une longue notice à la vie d’Abū l-ʿAtāhiya dont l’un des fils conducteurs est peut-être la question suivante : comment le représentant le plus célèbre de la poésie ascétique a-t-il pu faire l’objet d’accusations de zandaqa aussi insistantes ? Discrète apologie du poète, le texte d’al-Iṣfahānī nous montre que la duplicité qui lui est prêtée résulte davantage de sa position paradoxale d’ascète-courtisan que de ses convictions religieuses d’ailleurs fluctuantes. Cette lecture reste une spécificité du Kitāb al-Aġānī, car les grands dictionnaires des siècles suivants s’efforcent de gommer les ambiguïtés et les incohérences d’Abū l-ʿAtāhiya, pour construire la figure qui nous est familière aujourd’hui : celle d’un homme qui, après une jeunesse dissolue, se convertit et se consacre exclusivement à appeler ses contemporains à tourner leurs actions vers la vie future.