bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drooling outcome measures in paediatric disability: a systematic review
Authors: Sforza E. , Onesimo R. , Leoni C. , Giorgio V. , Proli F. , Notaro F. , Kuczynska E. M. , Cerchiari A. , Selicorni A. , Rigante D. , Zampino G. 
Published: April 2022

Abstract
Drooling, or sialorrhea, is a common condition in patients with cerebral palsy, rare diseases, and neurodevelopmental disorders. The goal of this review was to identify the different properties of sialorrhea outcome measures in children. Four databases were analysed in search of sialorrhea measurement tools, and the review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. The COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) checklist was used for quality appraisal of the outcome measures. The initial search yielded 891 articles, 430 of which were duplicates. Thus, 461 full-text articles were evaluated. Among these, 21 met the inclusion criteria, reporting 19 different outcome measures that encompassed both quantitative measures and parent/proxy questionnaires. Conclusions: Among the outcome measures found through this review, the 5-min Drooling Quotient can objectively discriminate sialorrhea frequency in patients with developmental disabilities. The Drooling Impact Scale can be used to evaluate changes after treatment. The modified drooling questionnaire can measure sialorrhea severity and its social acceptability. To date, the tests proposed in this review are the only tools displaying adequate measurement properties. The acquisition of new data about reliability, validity, and responsiveness of these tests will confirm our findings.

What is Known:• Although sialorrhea is a recognized problem in children with disabilities, especially those with cerebral palsy (CP), there is a lack of confidence among physicians in measuring sialorrhea.

What is New:• Few sialorrhea measures are available for clinicians that may guide decision-making and at the same time have strong evidence to provide confidence in the results.• A combination of both quantitative measures and parent/proxy questionnaires might provide an adequate measurement of sialorrhea in children.
Horizontal grid spacing comparison among Random Forest algorithms to nowcast Cloud-to-Ground lightning occurrence
Authors: La Fata Alice , Amato Federico , Bernardi Marina , D’Andrea Mirko , Procopio Renato , Fiori Elisabetta 
Published: April 2022

AbstractThe relation between the increase in the frequency and the effects of extreme events with climate change has been widely demonstrated and the related consequences are a global concern. In this framework, the strong correlation between significant lightning occurrence and intense precipitation events has been also documented. Consequently, the possibility of having a short-term forecasting tool of the lightning activity may help in identifying and monitoring the evolution of severe weather events on very short time ranges. The present paper proposes an application of Random Forest (RF), a popular Machine Learning (ML) algorithm, to perform a nowcasting of Cloud-to-Ground (CG) lightning occurrence over the Italian territory and the surrounding seas during the months of August, September, and October from 2017 to 2019. Results obtained with three different spatial resolutions have been compared, suggesting that, to enhance the skills of the model in identifying the presence or absence of strokes, all the data selected as input should be commonly gridded on the finest available spatial resolution. Moreover, the features’ importance analysis performed confirms that meteorological features describing the state of the atmosphere, especially at higher altitudes, have a stronger impact on the final result than topology data, such as Latitude or Digital Elevation Model (DEM).
Detecting space–time patterns of disease risk under dynamic background population
Authors: Hohl Alexander , Tang Wenwu , Casas Irene , Shi Xun , Delmelle Eric 
Published: April 2022

AbstractWe are able to collect vast quantities of spatiotemporal data due to recent technological advances. Exploratory space–time data analysis approaches can facilitate the detection of patterns and formation of hypotheses about their driving processes. However, geographic patterns of social phenomena like crime or disease are driven by the underlying population. This research aims for incorporating temporal population dynamics into spatial analysis, a key omission of previous methods. As population data are becoming available at finer spatial and temporal granularity, we are increasingly able to capture the dynamic patterns of human activity. In this paper, we modify the space–time kernel density estimation method by accounting for spatially and temporally dynamic background populations (ST-DB), assess the benefits of considering the temporal dimension and finally, compare ST-DB to its purely spatial counterpart. We delineate clusters and compare them, as well as their significance, across multiple parameter configurations. We apply ST-DB to an outbreak of dengue fever in Cali, Colombia during 2010–2011. Our results show that incorporating the temporal dimension improves our ability to delineate significant clusters. This study addresses an urgent need in the spatiotemporal analysis literature by using population data at high spatial and temporal resolutions.
Real-world safety and effectiveness of nivolumab for advanced renal cell carcinoma in Japan: a post-marketing surveillance
Authors: Uemura Hirotsugu , Tomita Yoshihiko , Nonomura Norio , Yoshizaki Kenji , Nakao Takafumi , Shinohara Nobuo 
Published: April 2022

Abstract
Background
This all-case post-marketing surveillance (PMS) evaluated the real-world safety and effectiveness of nivolumab monotherapy in Japanese patients with un-resectable or metastatic renal cell carcinoma (RCC).

Methods
This multicenter, open-label, non-interventional, observational PMS study (registered from August 2016 to January 2017) was conducted in patients who were newly initiated on nivolumab monotherapy. Assessments included treatment-related adverse events (TRAEs) of special interest, patient characteristics affecting safety, and effectiveness over 12 months.

Results
Overall, 580 patients were enrolled; 555 and 554 patients comprised the safety and effectiveness analysis sets, respectively. The median (range) age of the population was 66 (14–90) years. Nivolumab was initiated as 1st-, 2nd-, and ≥ 3rd-line treatment in 0.2%, 42.0%, and 57.8% of patients, respectively. TRAEs were reported in 275 (49.5%) patients. The most common TRAEs of special interest included thyroid dysfunction (9.5%), hepatic dysfunction (8.6%), and interstitial lung disease (6.7%). The incidence of TRAEs was significantly higher in elderly patients (≥ 65 vs < 65 years; ≥ 75 vs < 75 years); patients with lower C-reactive protein levels (< 5 vs ≥ 5 mg/dL); and patients with vs without a past medical history, including hepatic, thyroid, and autoimmune diseases. The 6- and 12-month survival rates were 71.8% and 57.9%, respectively.

Conclusion
The safety profile of nivolumab monotherapy in Japanese patients with advanced RCC was similar to that in the phase 3 CheckMate 025 trial. No new safety signals were observed in this study.
Re-assessing Middle Nubian cultural constructs through ceramic petrography
Authors: de Souza Aaron M. , Ownby Mary F. 
Published: April 2022

AbstractThis study employs ceramic petrography to establish if the existing typology-based divisions for the so-called Middle Nubian cultures can be related to variations in Nubian ceramic technologies during the mid-second millennium BC (c. 1800–1550 BC). Raw materials, paste recipes, and firing technology are analyzed to identify similarities and differences between the C-Group, Pan-Grave, and Kerma ceramic traditions. Three distinct fabric groups could be identified. Each corresponds, suggestively, to one of the existing cultural units. It is proposed that these variations reflect different approaches to resource acquisition and processing as well as distinct firing processes. Although these technological groups may relate to chronology and subsistence strategies, more evidence is needed before directly linking ceramic technologies to cultural units.
PrEP uptake and delivery setting preferences among clients visiting six healthcare facilities in Eswatini
Authors: Inghels Maxime , Kim Hae-Young , Tanser Frank , Hettema Anita , McMahon Shannon A. , Oldenburg Catherine E. , Matse Sindy , Kohler Stefan , Geldsetzer Pascal , Bärnighausen Till 
Published: April 2022

AbstractDue to the high HIV incidence among the general population of Eswatini, pre-exposure prophylaxis (PrEP) for HIV-exposed individuals is recommended. However, little is known about PrEP uptake and preferences in PrEP delivery healthcare setting among the general population. We conducted a secondary analysis of a randomized trial that aimed to increase PrEP uptake. All clients eligible for PrEP in one of six public-sector healthcare facilities in Eswatini were included. PrEP uptake was stratified by initial reason for visit (e.g. outpatient). Preferences in PrEP delivery setting were collected among those clients who initiated PrEP. A total of 1782 clients had their HIV acquisition risk assessed. Of these, 72% (1277/1782) were considered at risk by healthcare providers and, among them, 40% (517/1277) initiated PrEP. Uptake was higher among clients visiting specifically to initiate PrEP (93%), followed by HIV testing visits (45.8%) and outpatient visits (40%). Among those who initiated PrEP, preferred delivery settings were outpatient services (31%), HIV testing services (26%), family planning (21%) and antenatal services (14%). Men or those at high risk of HIV acquisition were more likely to prefer HIV testing and outpatient services, while young women were more likely to visit and express a preference for antenatal and family planning services. Outpatient services and HIV testing services could be preferable choices for PrEP delivery integration, due to the high PrEP uptake and delivery setting preferences of the populations who use these services. Antenatal and family planning could also be considered with a view to targeting the youngest women.
Conservation value of semi-open habitats for ground beetles (Coleoptera: Carabidae, Cicindelidae) in Central Europe
Authors: Boutaud Estève , Nolte Dorothea , Harry Ingmar , Assmann Thorsten , Drees Claudia 
Published: April 2022

AbstractReintroduction of grazing to counteract insect decline will lead to an increase of semi-open habitats. Semi-open habitats are highly heterogeneous, consisting of a mosaic of patches of trees or shrubs embedded in a matrix dominated by dwarf shrubs or grasses. Despite a lack of evidence, structural heterogeneity is expected to allow many species to co-occur, making semi-open habitats appear highly valuable for invertebrate conservation. We studied ground beetles in eight sites in two landscapes of Central Europe each encompassing semi-open, open, and forest habitats. Rapid response to environmental change and limited dispersal abilities make ground beetles an excellent model taxon to evaluate the effectiveness of such conservations measures. In both studied landscapes, ground beetle assemblages in semi-open habitats tended to be distinct and intermediate between those from the forest and open habitats. Species richness and functional diversity in semi-open habitats were similar to open habitats at site level. The majority of species entered the semi-open habitats, except for most threatened species, yet, few species were exclusively associated with semi-open habitats. We conclude that the continuous presence of many species in semi-open habitats likely results from mass effects rather than habitat heterogeneity per se. Our findings underline the conservation value of the existing forest, heathland, and grassland habitats over semi-open habitats which can, however, function as dispersal habitats and increase landscape connectivity. Strategies aiming at promoting semi-open habitats to counteract insect decline should target enhancing connectivity rather than the creation of habitats only.
When it Rains, it Pours: Estimating the Spatial Spillover Effect of Rainfall
Authors: Hossain Farzana , Ahsan Reshad N. 
Published: April 2022

AbstractA large fraction of the world’s poor rely on rain-fed agriculture, which makes them vulnerable to changes in rainfall patterns. In this paper, we examine whether spatial correlation in rainfall results in these households also being vulnerable to an adverse spatial-spillover effect. In particular, we use household-level panel data from India along with high-resolution meteorological data to show how rural household consumption varies with own-region rainfall as well as rainfall in neighboring areas. We find that while greater own rainfall has a positive effect on rural household consumption, greater rainfall in neighboring regions has an adverse spatial-spillover effect. Our results suggest that when this spillover effect is taken into account, the positive impact of own-region rainfall on household consumption falls by 38 percent.
Switching strategy-based hybrid evolutionary algorithms for job shop scheduling problems
Authors: Mahmud Shahed , Chakrabortty Ripon K. , Abbasi Alireza , Ryan Michael J. 
Published: April 2022

AbstractSince production efficiency and costs are directly affected by the ways in which jobs are scheduled, scholars have advanced a number of meta-heuristic algorithms to solve the job shop scheduling problem (JSSP). Although this JSSP is widely accepted as a computationally intractable NP-hard problem in combinatorial optimization, its solution is essential in manufacturing. This study proposes performance-driven meta-heuristic switching approaches that utilize the capabilities of multi-operator differential evolution (MODE) and particle swarm optimization (PSO) in a single algorithmic framework. The performance-driven switching mechanism is introduced to switch the population from an under-performing algorithm to other possibilities. A mixed selection strategy is employed to ensure the diversity and quality of the initial population, whereas a diversity check mechanism maintains population diversity over the generations. Moreover, a Tabu search (TS) inspired local search technique is implemented to enhance the proposed algorithm’s exploitation capability, avoiding being trapped in the local optima. Finally, this study presents two mixed population structure-based hybrid evolutionary algorithms (HEAs), such as a predictive sequence HEA (sHEA) and a random sequence HEA (rHEA), and one bi-population inspired HEA, called bHEA. The comparative impacts of these varied population structure-based approaches are assessed by solving 5 categories of the standard JSSP instances (i.e., FT, LA, ORB, ABZ and TA). The performance of these hybridized approaches (i.e., sHEA, rHEA and bHEA) is compared and contrasted with its constituent algorithms (MODE, PSO and TS) to validate the hybridization’s effectiveness. The statistical analysis shows that sHEA ranked first with mean value 1.84 compared to rHEA (1.96) and bHEA (2.21). Moreover, the proposed sHEA is compared with 26 existing algorithms and ranked first with a mean value 5.09 compared to the near-best algorithms. Thus, the simulation results and statistical analysis prove the supremacy of the sHEA.
Exploring the impact of suicide care experiences and post-intervention supports sought among community pharmacists: a cross-sectional survey
Authors: El-Den Sarira , Choong Huai-Jin , Moles Rebekah J. , Murphy Andrea , Gardner David , Rosen Alan , O’Reilly Claire L. 
Published: April 2022

Abstract
Background
There is a need to appropriately train, support and remunerate pharmacists for their expanding roles in mental healthcare. Pharmacists often care for people experiencing mental health crises, including suicidal thoughts and behaviours, but little is known about pharmacists’ suicide care experiences.

Aim
This cross-sectional study aimed to explore the impact of professional experiences with people at risk of suicide and support accessed, among community pharmacists.

Method
A survey exploring pharmacists’ experiences with people at risk of suicide and post-intervention support-seeking was disseminated through Australian and Canadian professional associations, conferences and social media (June 2016-May 2017). Quantitative data were analysed using Chi-squared, Fisher’s exact and independent t-tests, where appropriate. Qualitative data exploring the impact of these experiences were thematically analysed, and reasons for not seeking help post-intervention were identified.

Results
Among 378 respondents, 84% had encountered patients at risk of suicide and 28% had lost patients to suicide. Some were negatively affected personally and/or professionally (11%), of which 88% did not seek professional support, mainly due to uncertainty about available services. Pharmacists were significantly more negatively affected if they had a personal mental health diagnosis (p = 0.017) and previous suicide care experiences (p = 0.001). Qualitative themes included: expanding knowledge and skills, role limitation and emotional impact and response.

Conclusion
A large proportion of pharmacists have interacted with suicidal patients and are impacted by these experiences, yet few seek help due to lack of awareness and access. There is a need to recognize pharmacists’ roles in suicide care, and develop pharmacist-specific post-intervention support.
‘Genuine’ or ‘Quasi’ Self-Employment: Who Can Tell?
Authors: Kösters Lian , Smits Wendy 
Published: April 2022

AbstractIn many industrialised countries, including the Netherlands, the share of solo self-employed workers has strongly increased in recent years. This development is subject to a lot of public debate as it is feared that this increase is caused by ‘quasi’ self-employment. There still seems to be little consensus, however, on what constitutes ‘genuine’ self-employment and what not. In this article we present a theoretical framework for ‘quasi’ solo self-employment and discuss how the various indicators for ‘quasi’ self-employment that are used in the literature fit in this framework. We then compare the outcomes of different indicators by applying them to solo self-employed workers in the Netherlands. The data used for the analysis are taken from the Dutch Labour Force Survey (NL-LFS) 2017 complemented with the European Labour Force Survey (EU-LFS) ad hoc module 2017 on self-employment. Our results show that about 7% of the solo self-employed workers is dependent on one client. Furthermore, almost 20% of all solo self-employed had an involuntary start. The correspondence between dependency and involuntariness is very low: less than 2% of the solo self-employed workers are both dependent and involuntary. Both dependency and voluntariness are related to the fiscal and legal status of the solo self-employed workers and to the type of work activities. Solo self-employed workers that own their own business and who mainly sell products are less likely to be dependent and/or involuntary self-employed compared to those who do not own a business and/or offer services. Dependency is hardly related to the unfavourable outcomes of solo self-employment. Involuntariness, on the contrary, seems to have some impact on outcomes. Those who became self-employed because they couldn’t find a job as an employee have a higher probability to be unsatisfied with their job, to have financial problems or problems due to a lack of work or a low income. Nevertheless even among the involuntary solo self-employed workers, the majority does not report negative outcomes.
Exploring the Circular Polarisation of Low–Frequency Solar Radio Bursts with LOFAR
Authors: Morosan Diana E. , Räsänen Juska E. , Kumari Anshu , Kilpua Emilia K. J. , Bisi Mario M. , Dabrowski Bartosz , Krankowski Andrzej , Magdalenić Jasmina , Mann Gottfried , Rothkaehl Hanna , Vocks Christian , Zucca Pietro 
Published: April 2022

AbstractThe Sun is an active star that often produces numerous bursts of electromagnetic radiation at radio wavelengths. Low frequency radio bursts have recently been brought back to light with the advancement of novel radio interferometers. However, their polarisation properties have not yet been explored in detail, especially with the Low Frequency Array (LOFAR), due to difficulties in calibrating the data and accounting for instrumental leakage. Here, using a unique method to correct the polarisation observations, we explore the circular polarisation of different sub-types of solar type III radio bursts and a type I noise storm observed with LOFAR, which occurred during March–April 2019. We analysed six individual radio bursts from two different dates. We present the first Stokes V low frequency images of the Sun with LOFAR in tied-array mode observations. We find that the degree of circular polarisation for each of the selected bursts increases with frequency for fundamental emission, while this trend is either not clear or absent for harmonic emission. The type III bursts studied, that are part of a long–lasting type III storm, can have different senses of circular polarisation, occur at different locations and have different propagation directions. This indicates that the type III bursts forming a classical type III storm do not necessarily have a common origin, but instead they indicate the existence of multiple, possibly unrelated acceleration processes originating from solar minimum active regions.
Recent developments in microbial production of high-purity galacto-oligosaccharides
Authors: Maráz Anna , Kovács Zoltán , Benjamins Eric , Pázmándi Melinda 
Published: April 2022

AbstractGalacto-oligosaccharides (GOS) are used as prebiotic ingredients in various food and pharmaceutical formulations. Currently, production of GOS involves the enzymatic conversion of lactose by transgalactosylation using β-galactosidase. The purity of the resulting product is low, typically limited to up to 55% GOS on total carbohydrate basis due to the presence of non-reacted lactose, and the formation of by-products glucose and galactose. In industrial practice high-purity GOS is manufactured by removing the unwanted mono- and disaccharides from raw GOS with simulated moving bed (SMB) chromatography. This purification step is associated with high processing cost that increases the price of pure GOS and limits its marketability. The last decades have witnessed a growing interest in developing competitive biotechnological processes that could replace chromatography. This paper presents a comprehensive review on the recent advancements of microbial GOS purification, a process commonly referred to as selective fermentation or selective metabolism. Purification strategies include: (i) removal of glucose alone or together with galactose by lactose negative yeast species, that typically results in purity values below 60% due to remaining lactose; (ii) removal of both mono- and disaccharides by combining the fast monosaccharide metabolizing capacity of some yeast species with efficient lactose consumption by certain lactose positive microbes, reaching GOS purity in the range of 60–95%; and (iii) the application of selected strains of Kluyveromyces species with high lactose metabolizing activity to achieve high-purity GOS that is practically free from lactose and monosaccharides.
Graphical abstract