bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative in vitro and in vivo study of porcine‐ and bovine‐derived non‐cross‐linked collagen membranes
Authors: Zhu Mengdi , Duan Beibei , Hou Kegui , Mao Lisha , Wang Xuejiu 
Published: October 2022

AbstractThe porcine‐derived non‐cross‐linked collagen membrane Bio‐gide® (BG) and the bovine‐derived non‐cross‐linked collagen membrane Heal‐all® (HA) were compared to better understand their in vitro biophysical characteristics and in vivo degradation patterns as a reference for clinical applications. It was showed that the porosity, specific surface area, pore volume and pore diameter of BG were larger than those of HA (64.5 ± 5.2% vs. 48.6 ± 6.1%; 18.6 ± 2.8 m2/g vs. 2.3 ± 0.6 m2/g; 0.114 ± 0.002 cm3/g vs. 0.003 ± 0.001 cm3/g; 24.4 ± 3.5 nm vs. 7.3 ± 1.7 nm, respectively); the average swelling ratio of BG was higher than that of HA (412.6 ± 41.2% vs. 270.0 ± 2.7%); the tensile strength of both dry and wet HA was higher than those of BG (18.26 ± 3.27 MPa vs. 4.02 ± 1.35 MPa; 2.24 ± 0.21 MPa vs. 0.16 ± 0.02 MPa, respectively); 73% of HA remained after 72 h in collagenase solution, whereas only 8.2% of BG remained. A subcutaneous rat implantation model revealed that, at 3, 7, 14, 28, and 56 days postmembrane implantation, there were more total inflammatory cells, especially more M1 and M2 polarized macrophages and higher M2/M1 ratio in BG than in HA; in addition, the fibrous capsule around BG was also thicker than that around HA. Moreover, concentrations of dozens of cytokines including interleukin‐2(IL‐2), IL‐7, IL‐10 and so forth. in BG were higher than those in HA. It is suggested that BG and HA might be suitable for different clinical applications according to their different characteristics.
The development and initial validation of self‐report measures of ICD‐11 depressive episode and generalized anxiety disorder: The International Depression Questionnaire (IDQ) and the International Anxiety Questionnaire (IAQ)
Authors: Shevlin Mark , Hyland Philip , Butter Sarah , McBride Orla , Hartman Todd K. , Karatzias Thanos , Bentall Richard P. 
Published: October 2022

AbstractBackgroundThe new International Classification of Diseases came into effect in 2022 (ICD‐11; World Health Organization, 2022) and included updated descriptions and diagnostic rules for “Depressive Episode” and “Generalized Anxiety Disorder.” No self‐report measures align with these disorders so this study reports the development and initial validation of the “International Depression Questionnaire” (IDQ) and “International Anxiety Questionnaire” (IAQ).MethodsItems were developed that aligned to the ICD‐11 descriptions and their performance was assessed using data from a community sample (N = 2058) that was representative of the United Kingdom adult population.ResultsItem response theory models indicated that the two scales were unidimensional, and the items performed well in terms of difficulty and discrimination. Estimates of internal reliability were high. Based on ICD‐11 derived diagnostic algorithms, 7.4% met requirements for ICD‐11 Depressive Episode and 7.1% for Generalized Anxiety Disorder.ConclusionsThe IDQ and the IAQ are short, easy to use, self‐report measures aligned to the new and updated ICD‐11 diagnostic descriptions. This study provides initial evidence that the scales produce scores that are reliable and valid.
Tulostoma loonbanglaense: A new species from Azad Jammu and Kashmir using light and scanning electron microscopy and DNA barcoding technique
Authors: Niazi Abdul Rehman , Ghafoor Aneeqa , Afshan Najam‐ul‐Sehar , Moreno Gabriel 
Published: October 2022

AbstractTulostoma loonbanglaense sp. nov. is described from Azad Jammu and Kashmir, Pakistan. ITS sequences confirm its position within the genus Tulostoma, and suggest that it is separate from other identified species of this genus. The species has globose to subglobose, with wide, solitary and appressed spines basidiospores, the basidiospores are relatively small, 4.39 × 4.23 μm, that make it distinguished from the related species. Sequences of nr ITS region of the newly described species nested as a distinct taxon in both phylogenetic analyses of the current study.
Integrins are enriched on aberrantly fucosylated tumour‐derived urinary extracellular vesicles
Authors: Islam Md. Khirul , Dhondt Bert , Syed Parvez , Khan Misba , Gidwani Kamlesh , Webber Jason , Hendrix An , Jenster Guido , Lamminen Tarja , Boström Peter J. , Pettersson Kim , Lamminmäki Urpo , Leivo Janne 
Published: October 2022

AbstractUrinary extracellular vesicles (uEVs) are enriched with glycosylated proteins which have been extensively studied as putative biomarkers of urological cancers. Here, we characterized the glycosylation and integrin profile of EVs derived from urological cancer cell lines. We used fluorescent europium‐doped nanoparticles coated with lectins and antibodies to identify a biomarker combination consisting of integrin subunit alpha 3 (ITGA3) and fucose. In addition, we used the same cancer cell line‐derived EVs as analytical standards to assess the sensitivity of the ITGA3‐UEA assay. The clinical performance of the ITGA3‐UEA assay was analysed using urine samples of various urological pathologies including diagnostically challenging benign prostatic hyperplasia (BPH), prostate cancer (PCa) and bladder cancer (BlCa). The assay can significantly discriminate BlCa from all other patient groups: PCa (9.2‐fold;p = 0.00038), BPH (5.5‐fold;p = 0.004) and healthy individuals (and 23‐fold;p = 0.0001). Our results demonstrate that aberrantly fucosylated uEVs and integrin ITGA3 can be detected with fucose‐specific lectin UEA in a simple bioaffinity assay for the detection of BlCa directly from unprocessed urine.
On bivariate modelling using a new statistical distribution with homogeneous marginals
Authors: Poonia Neeraj , Azad Sarita 
Published: October 2022

AbstractRecent studies have shown that the univariate exponentiated Teissier distribution is an effective model for analysing rainfall data. A bivariate probability distribution offers greater insight into a process like a flood or drought than a univariate method for analysing the characteristics of environmental occurrences. As a result, in this study we developed a bivariate exponentiated Teissier distribution. The marginals of the proposed distribution model follow the exponentiated Teissier distribution. The cumulative distribution function of this bivariate model consists of continuous and singular components. The proposed model is shown to have several fundamental statistical properties, including joint cumulative distribution, joint density, marginals, and conditional distributions. Additionally, some copula functions are examined. The proposed model's parameter estimations are derived using the maximum likelihood method. Furthermore, the asymptotic confidence intervals are given for these estimates. A Monte Carlo simulation study with various sample sizes was performed to evaluate the behaviour of maximum likelihood estimates. Finally, we used football and flood datasets to demonstrate how the proposed model may be employed.
Ultrasound‐Guided Trigger Point Injections for the Treatment of Neck and Back Pain in the Emergency Department
Authors: Farrow Robert A. , Newberry Mark , Zitek Tony , Farrow Jackie , Mechanic Oren J. , Rosselli Michael 
Published: October 2022

ObjectivesPatients frequently present to the emergency department (ED) with neck or back pain, which can be difficult to treat. We sought to compare ultrasound‐guided trigger point injection (TPI) to standard medications for patients with neck or back pain.MethodsWe performed a single‐center, open label, randomized controlled trial on ED patients with neck or back pain from myofascial pain syndrome comparing ultrasound‐guided TPIs to those who received the combination of a nonsteroidal anti‐inflammatory drug (NSAID) and a muscle relaxant (MR). The primary outcome of this study was the reduction in mean pain score at the time of ED disposition.ResultsIn total, we analyzed 196 patients. At the time of ED disposition, patients in the TPI group had a mean reduction in their pain scores of 45.0 mm as compared to 49.9 mm in the NSAID plus MR group (difference: 4.9 [95% confidence interval (CI) −3.0 to 12.7], P = .22). At the first reassessment, patients in the TPI group had greater pain reduction by 10.7 mm (95% CI 3.1 to 18.4). The rate of rescue therapy use was higher in the NSAID plus MR group (difference: 17.5% [95% CI 4.4 to 36.2]).ConclusionsWe found no difference in pain reduction at the time of ED disposition between patients randomized to the ultrasound‐guided TPI group as compared to those who received an NSAID plus a MR. However, patients in the TPI group had greater pain reduction at the time of first reassessment and lower rates of rescue therapy use.
Length of Stay in Patients Undergoing Tracheoplasty: A NSQIP Study
Authors: Patel Rushi , Dhanda Aatin K. , Georges Kirolos , Cohen David A. , Patel Prayag , Eloy Jean Anderson 
Published: October 2022

BackgroundProlonged length of stay (LOS) has been associated with increased morbidity and resource utilization in various surgical procedures. We aim to determine factors associated with increased hospital stay in patient undergoing tracheoplasty.MethodsThe 2012–2018 National Surgical Quality Improvement Program (NSQIP) database was queried for patients undergoing tracheoplasty. Patient LOS was the primary clinical outcome. A LOS >75th percentile was considered as prolonged and was utilized for bivariate analysis of demographic, comorbidity, and operative characteristics. LOS was utilized as a continuous variable for multivariate linear regression analysis.ResultsA total of 252 patients were queried. The majority of patients were female (67.5%), white (82.4%), and over the age of 65 (77.0%). Patients had a median LOS of 7 days with the 75th percentile cutoff being defined at 10 days. On bivariate analysis of associated comorbidities, patients with prolonged LOS were more commonly obese (72.4% vs. 53.1%, p = 0.009), diabetic (37.9% vs. 16.5%, p < 0.001), dyspneic (58.6% vs. 40.7%, p = 0.016), and had chronic steroid use (25.9% vs. 12.9%, p = 0.018). Multivariable logistic regression analysis demonstrated significant associations between prolonged LOS and both chronic obstructive pulmonary disorder (COPD) (OR: 3.43, p = 0.020) and chronic steroid use (OR: 3.81, p = 0.018).ConclusionsThis study elucidates factors associated with prolonged LOS in patients undergoing tracheoplasty. Patients with COPD and chronic steroid use were significantly associated with prolonged LOS.Level of Evidence4 Laryngoscope, 133:1938–1942, 2023
Metal‐Free Atom Transfer Radical Polymerization of PVDF‐Based Block Copolymers Catalyzed by Organic Photoredox Catalysts
Authors: Altomare Aldo , Loos Katja 
Published: October 2022

AbstractPoly(vinylidene fluoride) (PVDF) and its copolymers represent a class of electroactive fluoropolymers with very attractive piezo/ferroelectric properties that can be chemically modified to achieve high‐quality composites with improved properties. Here, the synthesis of poly(methyl methacrylate)‐b‐poly(vinylidene fluoride)‐b‐poly(methyl methacrylate) (PMMA‐b‐PVDF‐b‐PMMA) triblock copolymers via metal‐free light‐catalyzed atom transfer radical polymerization (ATRP) using organic photoredox catalysts (OPRC) and light of suitable wavelength is reported. Using benzoyl peroxide bearing an ATRP active group at both ends of the molecule, telechelic PVDF is synthesized, and is used as a macroinitiator in the metal‐free, light‐catalyzed ATRP in presence of methyl methacrylate (MMA), an OPRC, and light of suitable wavelength. Kinetic studies are performed by monitoring the monomer consumed in solution and by using 1H‐NMR to calculate the formation of the new PMMA blocks. Three of the five tested OPRC, operating through an oxidative quenching pathway, guarantee a good control over the polymerization, confirmed by the constant concentration of radicals during the process and by the linear growth of the conversion versus the percentage of monomer consumed. Chain extension reactions are also performed to prove chain‐end fidelity, as well as “light ON/light OFF” reactions to test the temporal control guaranteed by the external stimuli used to catalyze the polymerization.
Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism
Authors: Cleret de Langavant Laurent , Roze Emmanuel , Petit Aimée , Tressières Benoit , Gharbi‐Meliani Amin , Chaumont Hugo , Michel Patrick Pierre , Bachoud‐Lévi Anne‐Catherine , Remy Philippe , Edragas Régine , Lannuzel Annie 
Published: October 2022

AbstractBackgroundHigh consumption ofAnnona muricatafruit has been previously identified as a risk factor for atypical parkinsonism in the French Caribbean islands.ObjectiveWe tested whether consumption of Annonaceae products could worsen the clinical phenotype of patients with any form of degenerative parkinsonism.MethodsWe analyzed neurological data from 180 Caribbean parkinsonian patients and specifically looked for dose effects of lifelong, cumulative Annonaceae consumption on cognitive performance. Using unsupervised clustering, we identified one cluster with mild/moderate symptoms (N = 102) and one with severe symptoms including cognitive impairment (N = 78).ResultsWe showed that even low cumulative consumption of fruits/juices (>0.2 fruit‐years) or any consumption of herbal tea from Annonaceae worsen disease severity and cognitive deficits in degenerative parkinsonism including Parkinson's disease (OR fruits‐juices: 3.76 [95% CI: 1.13–15.18]; OR herbal tea: 2.91 [95% CI: 1.34–6.56]).ConclusionWe suggest that more restrictive public health preventive recommendations should be made regarding the consumption of Annonaceae products. © 2022 The Authors.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Cerebrospinal fluid characteristics of patients treated with intrathecal nusinersen for spinal muscular atrophy
Authors: Orbach Rotem , Sagi Liora , Sadot Efraim , Tokatly Latzer Itay , Shtamler Anna , Zisberg Tehila , Fattal‐Valevski Aviva 
Published: October 2022

AbstractIntroduction/AimsThere is limited information on the potential effects of repeated intrathecal antisense oligonucleotide drug delivery on cerebrospinal fluid (CSF) biochemical and blood cell profiles. This study aimed to examine longitudinal changes in the biochemical components (glucose, protein) and blood cell counts in the CSF of spinal muscular atrophy (SMA) patients treated with intrathecal nusinersen.MethodsWe collected and analyzed clinical and CSF parameters (cell count, protein, glucose, culture) of 50 individuals with SMA during nusinersen treatment (22 type 1, 17 type 2, and 11 type 3).ResultsThe median protein concentration at baseline and during treatment was within the normal range but rose during treatment and was significantly above baseline at the time of the ninth intrathecal injection (p = 0.02, two‐tailed Wilcoxon matched‐pairs test, and p = 0.0015, Friedman test for repeated measures). Further analysis showed that the increase in CSF protein concentration was evident for SMA types 2 and 3 patients, but not for type 1. This observation was also demonstrated by a significant correlation between the SMN2 gene copy number and the increase in CSF protein concentration (Spearman rank correlation test).DiscussionOur results demonstrate that a delayed increase in CSF protein concentration is expected during nusinersen treatment for SMA types 2 and 3. This might reflect the medication's effect and a possible therapeutic biochemical marker.
A nonsmooth method for spatial frictional contact dynamics of flexible multibody systems with large deformation
Authors: Wang Kun , Tian Qiang 
Published: October 2022

AbstractA nonsmooth contact dynamics computation methodology for spatial frictional contact dynamics of flexible multibody systems with large deformation is presented. The contact and friction conditions between contact bodies are formulated as a cone complementary problem (CCP). Based on the mortar discretization method, nonsmooth frictional contact formulations for surface‐to‐surface and beam‐to‐beam contact problems are derived. These formulations can be used to study a wide range of contact problems between three‐dimensional bodies, thin plates and beams. The nonsmooth multibody dynamics equations are solved by using the generalized‐ method. The CCP is solved by using the accelerated projected gradient descend (APGD) algorithm in each Newton's iteration. Finally, six numerical examples are provided to validate the proposed computation methodology.
Joining processes of CFRP‐Al sheets in automobile lightweighting technologies: A review
Authors: Han Shanling , Guang Xinjie , Li Zhiyong , Li Yong 
Published: October 2022

AbstractAccording to the development trend of modern car body, the future car body will be composed of steel, aluminum‐magnesium alloy, plastic, carbon fiber reinforced polymer (CFRP), and other lightweight materials. Hybrid material body represents the latest development trend of car body structure in the future. With the development of lightweight technology, the application of carbon fiber composite material in automobile bodies is increasing due to its exceptional performance. Therefore, the joining of carbon fiber sheets with dissimilar sheets process in the hybrid material body is a key technical problem that needs to be solved. In this paper, the existing joining processes of adhesive process, mechanical joining, welding process, and hybrid joining for carbon fiber composites are reviewed; the principle, development, advantages, and shortcomings of each process for carbon fiber composites joining processes are systematically described; and the latest progress of the joining process are introduced. The purpose is tantamount to broaden the application range of carbon fiber sheets with dissimilar sheets and provide reference for its extensive application in the development of hybrid car body and lightweight.
Are those with diabetes more willing to adhere to COVID‐19 guidance?
Authors: Walker Mark David , Lane Hakan 
Published: October 2022

AbstractBackground: Those with diabetes were at a higher risk of experiencing severe illness in the event of contracting COVID‐19. Did they therefore act more cautiously?Method: The Imperial ‘COVID‐19 Behavioural Tracker’ details the results of regular surveying on attitudes surrounding COVID‐19 guidance. Results from UK participants to questions reflecting willingness to adhere to important recommendations regarding everyday behaviour were examined. Responses from those with diabetes were compared to those stating none of a list of pre‐existing health conditions. The effect of gender and age was examined.Results: Respondents with diabetes showed higher willingness to follow guidance than those with no health conditions. Compliance varied over time; willingness to self‐isolate remained high throughout, while willingness to avoid shopping, avoid going out, or avoid large gatherings rose in winter months. Greater adherence was seen in older age ranges, and in females, for both those with diabetes and healthy respondents. A logistic regression underlined the influence of gender, showing it as the most important variable influencing willingness to follow guidance.Discussion: The results underline that interrelating factors influence health behaviour decisions. The results suggest that those with diabetes are likely to listen to advice provided to them by health care professionals. Copyright © 2022 John Wiley & Sons.
Getting it right first time – precision medicine in diabetes
Authors: Kilvert Anne , Fox Charles 
Published: October 2022

Abstract
Precision medicine – ‘The right therapy for the right patient at the right time – every time’ – has been a hot topic over the past few years. The definition refers not just to treatment but also to diagnosis, prevention and prognosis. The evidence base for precision medicine is drawn from three categories: (i) assessment of the genetic and metabolic state; (ii) interrogation of big data to inform disease categories; (iii) science‐guided preventative and treatment decisions.The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) launched the Precision Medicine in Diabetes Initiative (PMDI) in 2018. Their first consensus report was published in 2020, with a four‐phase plan in place to produce guidelines and commence education of clinicians and patients by 2025.The best example of precision medicine in diabetes is monogenic diabetes, for which a genetic test in an individual identifies a specific diabetes type with implications for treatment. At the other extreme, ADA/EASD guidelines for type 2 diabetes identify four broad groups (cardiovascular disease risk; risk of hypoglycaemia; weight; cost) to guide treatment choice. Data analysis has led to identification of clusters within type 2 diabetes, with different clinical and genetic characteristics, but simple clinical factors such as age, weight, and eGFR may be sufficient to predict therapeutic response.For precision medicine to benefit the millions of people with diabetes globally, characteristics used to identify the best treatment for subgroups of populations must be easily measured and inexpensive. Precision medicine is a tool to aid treatment selection but the final choice must lie with the person who will be taking the treatment. Copyright © 2022 John Wiley & Sons.
HARmonized Protocol Template to Enhance Reproducibility of hypothesis evaluating real‐world evidence studies on treatment effects: A good practices report of a joint ISPE/ISPOR task force
Authors: Wang Shirley V. , Pottegård Anton , Crown William , Arlett Peter , Ashcroft Darren M. , Benchimol Eric I. , Berger Marc L. , Crane Gracy , Goettsch Wim , Hua Wei , Kabadi Shaum , Kern David M. , Kurz Xavier , Langan Sinead , Nonaka Takahiro , Orsini Lucinda , Perez‐Gutthann Susana , Pinheiro Simone , Pratt Nicole , Schneeweiss Sebastian , Toussi Massoud , Williams Rebecca J. 
Published: October 2022

AbstractProblemAmbiguity in communication of key study parameters limits the utility of real‐world evidence (RWE) studies in healthcare decision‐making. Clear communication about data provenance, design, analysis, and implementation is needed. This would facilitate reproducibility, replication in independent data, and assessment of potential sources of bias.What We DidThe International Society for Pharmacoepidemiology (ISPE) and ISPOR–The Professional Society for Health Economics and Outcomes Research (ISPOR) convened a joint task force, including representation from key international stakeholders, to create a harmonized protocol template for RWE studies that evaluate a treatment effect and are intended to inform decision‐making. The template builds on existing efforts to improve transparency and incorporates recent insights regarding the level of detail needed to enable RWE study reproducibility. The overarching principle was to reach for sufficient clarity regarding data, design, analysis, and implementation to achieve 3 main goals. One, to help investigators thoroughly consider, then document their choices and rationale for key study parameters that define the causal question (e.g., target estimand), two, to facilitate decision‐making by enabling reviewers to readily assess potential for biases related to these choices, and three, to facilitate reproducibility.Strategies to Disseminate and Facilitate UseRecognizing that the impact of this harmonized template relies on uptake, we have outlined a plan to introduce and pilot the template with key international stakeholders over the next 2 years.ConclusionThe HARmonized Protocol Template to Enhance Reproducibility (HARPER) helps to create a shared understanding of intended scientific decisions through a common text, tabular and visual structure. The template provides a set of core recommendations for clear and reproducible RWE study protocols and is intended to be used as a backbone throughout the research process from developing a valid study protocol, to registration, through implementation and reporting on those implementation decisions.