bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Ki-67 Change Pattern After Core Needle Biopsy and Prognosis in HR+/HER2− Early Breast Cancer Patients
Authors: Li Shuai , Chen Xiaosong , Shen Kunwei 
Published: June 2022

BackgroundTo investigate the association of Ki-67 change pattern after core needle biopsy (CNB) and prognosis in HR+/HER2− early breast cancer patients.MethodEligible patients were categorized into three groups: Low group, Elevation group, and High group. Chi-square test and logistic regression analysis were used to compare the clinic-pathological characteristics. Kaplan–Meier method was used to estimate the rates of recurrence-free interval (RFI) and breast cancer-specific survival (BCSS), which were compared via the Log-rank test. Cox proportional hazard analysis was performed to investigate independent prognostic factors.ResultsA total of 2,858 patients were included: 1,179 (41.3%), 482 (16.9%), and 1,197 (41.8%) patients were classified into the low, elevation, and high groups, respectively. Age, tumor size, histological grade, lymph-vascular invasion (LVI), and ER level status were associated with Ki-67 change pattern after CNB. With a median follow-up of 53.6 months, the estimated 5-year RFI rates for the low group, elevation, and high groups were 96.4%, 95.3% and 90.9%, respectively (P &lt; 0.001). And 5-year BCSS rates were 99.3%, 98.3% and 96.8%, respectively (P = 0.001). Compared with patients in the low group, patients in the high group had significantly worse RFI (hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.16–2.54) in multivariate analysis.ConclusionsKi-67 change after CNB was associated with prognosis in HR+/HER2− early breast cancer. Patients with Ki-67 high or elevation after CNB had an inferior disease outcome, indicating the necessity of re-evaluating Ki-67 on surgical specimens after CNB.
Efficacy and Safety of Camrelizumab in Combination with Docetaxel + S-1 Sequenced by Camrelizumab + S-1 for Stage III (PD-1+/MSI-H/EBV+/dMMR) Gastric Cancer: Study Protocol for a Single-Center, Prospective, Open-Label, Single-Arm Trial
Authors: Dong Zhongyi , Ni Bo , Yang Linxi , Guan Yujing , Zhu Chunchao , Zhao Enhao , Zhao Gang , Xia Xiang , Zhang Zizhen 
Published: June 2022

BackgroundGastric cancer occupies the fourth highest morbidity rate of cancers worldwide. A higher incidence of gastric cancer had been found in East Asia compared to the other regions. Gastrectomy with radical lymph node dissection is the cornerstone of curative treatment for Stage III gastric cancer, and postoperative systemic chemotherapy with docetaxel, S-1 improved patients’ disease-free survival rates. However, advances in immunotherapy bring innovations in the management of patients with gastric cancer. The objective of this study was to explore the efficacy and safety of camrelizumab in combination with docetaxel + S-1, sequenced by camrelizumab + S-1 in stage III gastric cancer patients who are EBV positive, with defective mismatch repair and CPS ≥5.Methods and analysisThis prospective, open-label, single-arm trial was performed at Renji Hospital. In this study, a total of 70 adult patients aged 18–80 years with Stage III (PD-1+/MSI-H/EBV+/dMMR) gastric cancer confirmed by post-operative pathology will be enrolled after screening. Participants will receive the specific chemotherapy regimen until 1 year after the operation or until tumor recurrence or metastasis. The primary outcome is the 3-year disease-free survival rate measured by the Clopper-Pearson method and 95% confidence intervals. The secondary outcomes include overall survival, incidence and severity of adverse effects, and laboratory abnormalities. The data will be analyzed by the Kaplan-Meier method and log-rank test. The patients will be followed up every 3 months with imaging investigation until clinical remission.Ethics and disseminationAll participants will provide informed consent. The protocol has been approved by the Shanghai Jiaotong University School of Medicine, Renji Hospital Ethics Committee (KY2019-191). The results will be disseminated through peer-reviewed manuscripts, reports and presentations.Clinical Trial RegistrationClinicalTrials.gov, identifier: ChiCTR1900027123. Registration date November 2019; first enrolment December 2019; expected end date December 2021; trial status: Ongoing.Brief AbstractA clinical trial for Stage III (PD-1+/MSI-H/EBV+/dMMR) gastric cancer patients who accepted anti-PD-1 therapy combined with docetaxel + S-1 as the first-line treatment and explored improvements in three-year disease-free survival rate.
Osteoid Osteoma of the Proximal Femur: Pitfalls in Diagnosis and Performance of Open Surgical Resection
Authors: Zeng Hao , He Hongbo , Tong Xiaopeng , Wang Zhiwei , Luo Rongsheng , Liu Qing 
Published: June 2022

AimsProximal femoral osteoid osteoma (OO) is extremely easy to be misdiagnosed or missed. The purpose of this study was to retrospectively analyze the clinical data of patients with proximal femoral OO in order to determine the clinical manifestation and imaging characteristics of the disease, so as to provide help for the preoperative diagnosis and clinical treatment of proximal femoral OO.MethodsThis was a retrospective study involving 35 patients with proximal femoral OO admitted into our hospital from January 2015 to January 2021. The baseline characteristics of the participants included; 24 males and 11 females, aged between 13 and 25 (mean 16.2) years old, and the course of the disease was 1 to 14 (mean 6.3) months. We used previous medical experience records of the patients to analyze for the causes of misdiagnosis. Moreover, we compared the difference between preoperative and postoperative treatment practices in alleviating pain in OO patients and restoring hip function. Follow-ups were carried out regularly, and patients advised to avoid strenuous exercises for 3 months.ResultsWe followed up 35 patients (25 intercortical, 4 sub-periosteal, and 6 medullary) for an average of 41.4 months. We found that 15 patients (42.9%) had been misdiagnosed of synovitis, perthes disease, osteomyelitis, intra-articular infection, joint tuberculosis and hip impingement syndrome, whose average time from symptoms to diagnosis were 6.3 months. Postoperative pain score and joint function score improved significantly compared with preoperative, and complications were rare.ConclusionOpen surgical resection constitutes an effective treatment for proximal femoral OO by accurately and completely removing the nidus. Wrong choice of examination, and the complexity and diversity of clinical manifestations constitutes the main reasons for the misdiagnosis of proximal femoral OO.
Study on the Correlation Between CT Features and Vascular Tumor Thrombus Together With Nerve Invasion in Surgically Resected Lung Adenocarcinoma
Authors: Song Yu , Chen Daiwen , Lian Duohuang , Xu Shangwen , Xiao Hui 
Published: June 2022

BackgroundWe aimed to analyze the relationship between pulmonary adenocarcinoma patients with vascular tumor thrombus and nerve invasion and different CT features.MethodsThe preoperative CT scanning data of 86 patients with lung adenocarcinoma who underwent surgical resection in our hospital from January 2020 to January 2022 were analyzed in the form of retrospective analysis. The CT images of all patients were observed, and the relationship between them and vascular tumor thrombus and nerve invasion of lung adenocarcinoma was analyzed. At the same time, the sensitivity, specificity, and accuracy of enhanced CT and plain CT were compared to evaluate the diagnostic efficacy of both.ResultsThe results showed that the vascular tumor thrombus of lung adenocarcinoma was mainly related to the solid components and lobulated and calcified tumors in CT images, and the nerve invasion of lung adenocarcinoma was mainly related to the tumors with bronchial inflation sign in CT images (P &lt; 0.05). The sensitivity, specificity, and accuracy of enhanced CT in the diagnosis of vascular tumor thrombus were 78.26%, 96.83%, and 91.86%, respectively, and the sensitivity, specificity, and accuracy in the diagnosis of nerve invasion were 75.00%, 98.72%, and 96.51%, respectively. The sensitivity, specificity, and accuracy of plain CT in the diagnosis of vascular tumor thrombus were 43.48%, 92.06%, and 79.07%, respectively, and the sensitivity, specificity, and accuracy in the diagnosis of nerve invasion were 25.00%, 94.87%, and 88.37%, respectively. The contrast showed that the sensitivity and accuracy of enhanced CT were higher than those of plain CT (P &lt; 0.05), but the difference of specificity was not obvious (P &gt; 0.05).ConclusionsSolid components and lobulated and calcified tumors in CT signs are closely related to vascular tumor thrombus of lung adenocarcinoma, while patients with bronchial inflation sign are related to nerve invasion.
Cerebral Complications of Snakebite Envenoming: Case Studies
Authors: Huang Yu-Kai , Chen Yen-Chia , Liu Chia-Chun , Cheng Hui-Chun , Tu Anthony T. , Chang Kun-Che 
Published: June 2022

There are an estimated 5.4 million snakebite cases every year. People with snakebite envenoming suffer from severe complications, or even death. Although some review articles cover several topics of snakebite envenoming, a review of the cases regarding cerebral complications, especially rare syndromes, is lacking. Here, we overview 35 cases of snakebite by front-fanged snakes, including Bothrops, Daboia, Cerastes, Deinagkistrodon, Trimeresurus, and Crotalus in the Viperidae family; Bungarus and Naja in the Elapidae family, and Homoroselaps (rare cases) in the Lamprophiidae family. We also review three rare cases of snakebite by rear-fanged snakes, including Oxybelis and Leptodeira in the Colubridae family. In the cases of viper bites, most patients (17/24) were diagnosed with ischemic stroke and intracranial hemorrhage, leading to six deaths. We then discuss the potential underlying molecular mechanisms that cause these complications. In cases of elapid bites, neural, cardiac, and ophthalmic disorders are the main complications. Due to the small amount of venom injection and the inability to deep bite, all the rear-fanged snakebites did not develop any severe complications. To date, antivenom (AV) is the most effective therapy for snakebite envenoming. In the six cases of viper and elapid bites that did not receive AV, three cases (two by viper and one by elapid) resulted in death. This indicates that AV treatment is the key to survival after a venomous snakebite. Lastly, we also discuss several studies of therapeutic agents against snakebite-envenoming-induced complications, which could be potential adjuvants along with AV treatment. This article organizes the diagnosis of hemotoxic and neurotoxic envenoming, which may help ER doctors determine the treatment for unidentified snakebite.
Metal clusters trapped on opaque substrate particles prepared using pulsed laser ablation in liquid
Authors: Takeda Yoshihiro 
Published: June 2022

Abstract
Gold clusters trapped on opaque substrate particles were produced using pulsed laser ablation. The ablation laser irradiated the target Au plate in a liquid dispersed with opaque substrate particles. It was found that the rate of thermal diffusion from the smaller particle that absorbed laser energy was greater than that from the larger particle; therefore, it is less likely to increase the temperature. Subsequently, the Au target was ablated more efficiently than the opaque substrate particles dispersed in the liquid. Therefore, the opaque particles were barely miniaturized and remained intact. The interaction mechanism of the deposition of the Au particle produced by laser ablation on the substrate particles was investigated by measuring the zeta potential of the substrate particles. The positively charged Au particles were adsorbed by ion exchange with positively charged Y2O3 substrate particles. In contrast, they interacted via electrostatic interactions with negatively charged α-quartz and ZSM-5 zeolite particles.
Pulse light manipulate output state of 3.6 μm fluoride fiber laser in DWP system
Authors: Zhang Xin , Tong Cunzhu , Cai Kaidi , Wang Yanjing 
Published: June 2022

Abstract
Strong driving with light offers the potential to manipulate the properties of fluoride fiber on absorbed characteristics. A 3.6 μm continuous wave (CW) fiber laser pumped by the 1973 nm CW fiber laser and the 976 nm pulsed diode source was demonstrated in a dual-wavelength pumping (DWP) system. The output state could be changed from pulse to CW by controlling the repetition frequency and pumping power of the 976 nm pulsed pump source. By optimizing the pumping parameter, a maximum output power of 1.2 W was achieved for the 3.6 μm CW fiber laser. The demonstrated method shows a new solution for controlling the output state of 3.6 μm fiber lasers, which can be used to achieve high power CW laser output. These findings will be helpful for better understanding the interaction process of particle transition in DWP systems.
First-principles study of Fe2VAl and Fe2VAl/Si thin films and their magnetic properties
Authors: Kobayashi Kazuaki , Takaki Hirokazu , Shimono Masato , Ishii Hiroyuki , Kobayashi Nobuhiko , Hirose Kenji , Tsujii Naohito , Mori Takao 
Published: June 2022

Abstract
We studied thin films of Fe2VAl, Fe2VAl/Si, and a related compound using the total energy pseudopotential method. The internal atoms in a supercell of the repeated slab model were fully relaxed, except for Fe2VAl/Si. The detailed electronic and magnetic properties of structurally relaxed thin films of Fe2VAl, Fe2VAl/Si, and a related compound were calculated. These films are free-standing in the supercell, except for Fe2VAl/Si, which comprises Fe2VAl and Si (substrate) layers in a supercell. A thin film comprising Fe2V, Al, and Si (substrate) layers in the supercell (denoted as Fe2V/Al/Si) was also studied. Although electronic states of bulk Fe2VAl (full-Heusler) are metallic with pseudo-gap states around the Fermi level and nonmagnetic, the calculation results for Fe2VAl, Fe2VAl/Si, and Fe2V/Al/Si thin films in this study indicate that the films have ferromagnetic properties and their ferromagnetic states are energetically more favorable than nonmagnetic states. The magnetic moments are large and enhanced in the thin films. The magnetic moments of Fe in Fe2VAl (Fe12V4Al4), Fe2VAl (Fe20V8Al8), Fe2VAl/Si, and Fe2V/Al/Si thin films are 2.07 μ
B/per atom, 1.29 μ
B/per atom, 1.83 μ
B/per atom, and 2.22 μ
B/per atom, respectively. Although thin films have net ferromagnetic properties, the magnetic moments of the up and down spin states of Fe and V are antiferromagnetically aligned.
Automatic Detection of InSAR Surface Deformation Signals in the Presence of Severe Tropospheric Noise
Authors: Staniewicz Scott , Chen Jingyi 
Published: June 2022

<p>Automatic detection of surface deformation features from a large volume of Interferometric Synthetic Aperture Radar (InSAR) data is challenging, because the magnitude of InSAR measurement noise varies substantially in both space and time. In this work, we present a computer vision algorithm based on Laplacian of Gaussian (LoG) filtering for detecting the size and location of unknown surface deformation features. Because our algorithm detects spatially coherent “blob-like” features, tropospheric noise artifacts that share similar spatial characteristics may also be detected. We estimate the tropospheric noise spectrum directly from data, which allows us to simulate new instances of noise that resemble the actual InSAR observations. Based on these simulations, we quantify the likelihood that a detected feature is a real deformation signal. We demonstrate the performance of our algorithm using ascending and descending Sentinel-1 data acquired between 2014 and 2019 over the ∼80,000 km<sup>2</sup> oil-producing Permian Basin in West Texas, one of the most productive oil fields in the world. We detect clusters of deformation features associated with oil production, wastewater injection, and fault activities. The number of detected deformation features increases substantially over the study period, which is consistent with the overall rise in oil production within the Permian Basin since 2014. Our algorithm is robust and flexible, and can be readily integrated to various multi-temporal InSAR time series methods for detecting a broad range of deformation features. </p>
Encroachment on the life of an allegedly pregnant woman
Authors: Sitnikova Alexandra 
Published: June 2022

In article is attempted to consider the doctrinal views on the qualification of an assault that caused the death of an allegedly pregnant woman and to make a proposal to resolve this problem. The dialectical method in combination with instrumental methods of cognition is used as the methodological basis of this study.
Studying this problem, it is established that the variant of the qualification of the murder of an allegedly pregnant woman with an error in her physiological properties, proposed by representatives of the objective approach, and confirmed by the materials of judicial practice of the Supreme Court of the Russian Federation is more preferable. The qualification of the murder of an allegedly pregnant woman in the form of an attempt on the life of an obviously pregnant woman, as well as a set of crimes on various grounds specified in this article is criticized. It is shown that the variant of the qualification of an allegedly pregnant woman in the form of a set of crimes developed by representatives of the objectively- subjective direction, causes a number of unsolvable problems.
Thus, in order to carry out an adequate criminal legal assessment of the actions of the perpetrator who encroached on the life of a woman in the presence of a subjective error in her physiological properties, it is necessary that the Plenum of the Supreme Court of the Russian Federation give an explanation about the qualification of murder according to paragraph “g” of Part 2 of Article 105 of the Criminal Code.
Training of Personnel for the Ministry of Internal Affairs of the Russian Federation: problems and development prospects
Authors: Elizbaryan Artur 
Published: June 2022

The article is devoted to the evaluation of personnel system of the Ministry of Internal Affairs of the Russian Federation. General theoretical characteristics of the personnel system of the Ministry of Internal Affairs of the Russian Federation are given, the system of tasks of this system at the present stage of development is formed. Thanks to the theoretical and normative-legal analysis of the personnel system of the Ministry of Internal Affairs of the Russian Federation the place and the role of personnel policy in the system of unified state personnel policy has been revealed.
A direct correlation between the efficiency of functioning of internal affairs bodies and the clarity, specificity, and quality of training of the personnel system has been established. Training of the personnel system of the Ministry of Internal Affairs of the Russian Federation is an organized and purposeful process of mastering and constantly improving professional skills, knowledge and skills that are necessary for the successful performance of tasks assigned to the internal affairs bodies of the Russian Federation.
During the assessment of the internal content of the personnel system of the Ministry of Internal Affairs of the Russian Federation its principal aspects are highlighted, as well as formed directions of work with cadres of internal affairs bodies. In correlation of the theory of the question with the normative-legal regulation and the tasks of personnel training in the system of the Ministry of Internal Affairs of the Russian Federation prospective directions of development in this area have been determined.
PERBEDAAN PENGARUH METODE LATIHAN DODGING RUN DAN ZIG-ZAG RUN TERHADAP KELINCAHAN DRIBBLE DALAM PERMAINAN FUTSAL PADA ATLET PUTRA CLUB METAMORFOSA FUTSAL ACADEMY BOYOLALI TAHUN 2021
Authors: Putra Dedik Historyyana , Prabowo Rendra Agung 
Published: June 2022

ABSTRAK
Tujuan penelitian untuk mengetahui Perbedaan Pengaruh Metode Latihan Dodging Run Dan Zig-Zag Run Terhadap Kelincahan Dribble Dalam Dalam permainan futsal Pada Atlet Putra Club Metamorfosa Futsal Academy Boyolali Tahun 2021, dan jika ada perbedaan maka untuk mengetahui mana yang lebih baik antara Latihan Dodging Run Dan Zig-Zag Run Terhadap Kelincahan Dribble Dalam Dalam permainan futsal Pada Atlet Putra Club Metamorfosa Futsal Academy Boyolali Tahun 2021.
Sampel penelitian adalah Pada Atlet Putra Club Metamorfosa Futsal Academy Boyolali dengan jumlah 30 siswa. Pengambilan sampel menggunakan teknik Total Sampling. Variabel penelitian ini yaitu Hasil Kelincahan shooting dengan Latihan Dodging Run Dan Zig-zag Run sebagai variabel bebas serta hasil kelincahan dribble variabel terikat. Rancangan penelitian menggunakan pretest-posttest design. Tes untuk mengetahui kelincahan dribble menggunakan tes kelincahan dribble menggunakan petunjuk pelaksanaan tes dari Nur Hasan (2001: 157). Metode analisis data penelitian menggunakan rumus t-test yang diperhitungkan menggunakan rumus pendek.
Hasil analisis data maka simpulan diperoleh: (1) Ada Perbedaan Pengaruh Metode Latihan Dodging Run Dan Zig-Zag Run Terhadap Kelincahan Dribble Dalam permainan futsal Pada Atlet Putra Club Metamorfosa Futsal Academy Boyolali Tahun 2021. Hal ini dibuktikan dari hasil penghitungan tes akhir masing-masing kelompok yaitu thitung = 13.76 lebih kecil dari pada ttabel = 2,145 dengan taraf signifikasi 5%. (2) Latihan Dodging Run Dan Zig-Zag Run Terhadap Kelincahan Dribble Dalam permainan futsal Pada Atlet Putra Club Metamorfosa Futsal Academy Boyolali Tahun 2021. Berdasarkan persentase peningkatan Kelincahan Dribbling bola dalam permainan futsal menunjukkan bahwa kelompok 1 (kelompok yang mendapat perlakuan dengan Latihan Dodging Run) adalah 13.274% > kelompok 2 (kelompok yang mendapat Zig-Zag Run) adalah 10.378%.
Kata kunci : Dodging Run, Zig-Zag Run, Kelincahan Dribble, Futsal
IMPLEMENTASI METODE LATIHAN AUDIO VISUAL DAN LATIHAN VARIASI DALAM PERMAINAN SEPAKBOLA PADA ATLET PUTRA USIA 14 – 16 TAHUN KLUB JUNIOR SOCCER ACADEMY SUKOHARJO TAHUN 2021
Authors: Pipit Fitria Yulianto  , Aan Budi Santoso  , Kodrad Budiyono  , Narbito Ronny Suryo , Hartini  
Published: June 2022

ABSTRAK
Berdasarkan hasil pengabdian, secara umum guru-guru pelatih mampu memahami materi mengenai teknik dasar sepakbola menggunakan audio visual dan variasi sebagai media interaktif dalam pelatihan sepakbola. Untuk atlit junior juga merasakan lebih tertarik dan mampu mempraktikkan teknik dasar bermain sepakbola dengan lebih baik. Evaluasi kegiatan yang dilakukan selama proses kegiatan berlangsung, yaitu pada saat coaching clinic. Teknik evaluasi dilakukan dengan cara observasi, yaitu melihat bagaimana efektifkah media audio-visual dan latihan variasi yang dilakukan. Rata-rata atlit telah mampu menjalankan dengan baik.
Media video audio visual terdiri atas audio visual diam, yaitu media yang menampilkan suara dan gambar diam seperti film bingkai suara (sound slides), film rangkai suara dan audio visual gerak yaitu media yang menampilkan unsur suara dan gambar yang bergerak seperti film suara dan video cassette. Dilihat dari segi keadaannya, media audio visual dibagi menjadi audiovisual murni yaitu unsur suara maupun unsur gambar berasal dari suatu sumber seperti film audio cassette. Dari keterampilan awal sebelum diadakan pengabdian dibandingkan dengan sesudah pengabdian keterampilan bermain sepakbola meningkat cukup signifikan