bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operational Management and Financial Performance of Tourism Industry in Selected Towns of Batangas
Authors: Llanes Lady Grace Violy 
Published: September 2022

This study primarily aimed to accomplished four basic objectives, which are: determine the company profiles of tourism businesses at selected towns in Batangas; evaluate the level of effectiveness of the operating management practices of tourism companies in terms of the human resource, marketing and financial management; examine the level of their financial performance in terms of sales growth and profitability; and, find the significant correlation in the respondent’s assessment on the effectiveness of the operational management practices and financial performance of the tourism companies. This study employed the descriptive survey research method that engaged 270 proprietors and managers of different tourism enterprises across the province of Batangas. Convenient sampling technique was used and Statistical Packages for Social Sciences (SPSS) to process the data. The researcher utilized Frequency and Percentage Distribution, Weighted Mean and Pearson Correlation Coefficient.
The study revealed that most tourism businesses in selected towns in Batangas belong to Sun and Beach Tourism. Majority are sole proprietorship, with less than three million capitalizations. Years in business operation are mostly 1 to 5 years, with more than 20 employees. Findings illustrate that the majority of tourism businesses of Batangas gave more importance on certain aspects of operational management over the others. For financial management, financial control has been prioritized over financial planning. Marketing management is assessed as one of the most essential aspects of business operation. The study found a very weak to weak correlation in Human Resource, Financial and Marketing Management vs. Sales Revenue Growth and Profitability Growth.
Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics
Authors: Nafissi Navid A. , Abdulrahim Jawan W. , Kwee Lydia Coulter , Coniglio Amanda C. , Kraus William E. , Piccini Jonathan P. , Daubert James P. , Sun Albert Y. , Shah Svati H. 
Published: September 2022

Background:
Inherited primary arrhythmia syndromes and arrhythmogenic cardiomyopathies can lead to sudden cardiac arrest in otherwise healthy individuals. The burden and expression of these diseases in a real-world, well-phenotyped cardiovascular population is not well understood.

Methods:
Whole exome sequencing was performed on 8574 individuals from the CATHGEN cohort (Catheterization Genetics). Variants in 55 arrhythmia-related genes (associated with 8 disorders) were identified and assessed for pathogenicity based on American College of Genetics and Genomics/Association for Molecular Pathology criteria. Individuals carrying pathogenic/likely pathogenic (P/LP) variants were grouped by arrhythmogenic disorder and matched 1:5 to noncarrier controls based on age, sex, and genetic ancestry. Long-term phenotypic data were annotated through deep electronic health record review.

Results:

Fifty-eight P/LP variants were found in 79 individuals in 12 genes associated with 5 arrhythmogenic disorders (arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, hypertrophic cardiomyopathy,
LMNA
-related cardiomyopathy, and long QT syndrome). The penetrance of these P/LP variants in this cardiovascular cohort was 33%, 0%, 28%, 83%, and 4%, respectively. Carriers of P/LP variants associated with arrhythmogenic disorders showed significant differences in ECG, imaging, and clinical phenotypes compared with noncarriers, but displayed no difference in survival. Carriers of novel truncating variants in
FLNC, MYBPC3
, and
MYH7
also developed relevant arrhythmogenic cardiomyopathy phenotypes.

Conclusions:

In a real-world cardiovascular cohort, P/LP variants in arrhythmia-related genes were relatively common (1:108 prevalence) and most penetrant in
LMNA
. While hypertrophic cardiomyopathy P/LP variant carriers showed significant differences in clinical outcomes compared with noncarriers, carriers of P/LP variants associated with other arrhythmogenic disorders displayed only ECG differences.
‫الأطلال الناطقة: إعادة قراءة لحكاية ”مدينة النحاس“‬
Authors: Qian (أيلين تشيان) Ailin 
Published: September 2022

المستخلص
‫تُعرف الرحلة إلى ”مدينة النحاس“ بأنّها أكثر الرحلات تجهُّمًا في كتاب ألف ليلة وليلة. وقد وُضعت حكايتها في إثر الحملات الأمويّة إلى الشمال الإفريقيّ فترةَ خلافة عبد الملك (حكم 705‫–‬685). وتتضمّن الحكاية خبر رحلتينِ استكشافيّتين خياليّتين، إحداهما تبحث عن قماقم سليمان النحاسيّة، والأخرى عن مدينةٍ غامضة تُدعى مدينة النحاس. ومن أبرز مزايا هذه الحكاية أنّها تذكر اثني عشر مقطعًا من الشعر الزهديّ باللغة اليونانيّة (أو النثر المختلط بالشعر)، وقد نُقشت هذه المقاطع على الأبواب والألواح والأضرحة في أطلال تلك المدينة. وكان قائد الحملة موسى بن نُصير (ت 716) يبكي ويُغشى عليه كلّما سمع مقطعًا منها يُشرح له، ثمّ يطلب من أتباعه أن يكتبوه على قراطيس. ولذلك يمكن ربط هاتين الرحلتين الاستكشافيّتين بالأثريّات، أي زيارة الأطلال وجمع قصائد في الزهد منها.‬
‫في فترة الحكم الطويلة للإمبراطور تشيانلونغ (Qianlong، حكم 1795‫–‬1735)، كان اهتمامه بالوظيفة القوميّة لدراسة الآثار سببًا في ظهور الأبحاث من جديد في تشينغ الصينيّة (Qing China). وفي عام 1796، أصدر عالم الآثار والرسّام الصينيّ هوانغ يي (‫Huang Yi‬، 1801‫–‬1744) أكثر من 400 كُتيّب عن النقوش التي نقّب عنها في رحلته التي دامت شهرًا إلى جبل سونغ (Mount Song) وعاصمة لويانغ (Luoyang) القديمة. ويحتفظ متحف القصر في بيجينغ (Beijing) بألبومه المؤلّف من 24 ورقة، تصوّر كلٌّ منها مكانًا رآه هوانغ يي وترفق الصورةَ بوصف مكتوب. يعتمد هذا البحث على ألبوم هوانغ يي لإعادة بناء مشهدٍ أتمّ لرحلة موسى بحثًا عن الآثار في مدينة النحاس.‬
عن الأثر والأنقاض ومفاهيمها الوجوديّة في روايات الكاتب جان دوست
Authors: Bawardi (باسيليوس حنّا بواردي) Basilius 
Published: September 2022

المستخلص
تتناول هذه المقالة مفهوم أنقاض ما بعد الحرب وآثارها في روايات الكاتب الكرديّ السوريّ جان دوست (–1965) كجزء من مفهومه العامّ حول مسائل الهويّة والذاكرة وكتابة التاريخ. وتتتبّع هذه المقالة، عن طريق مفهوم الأثر/الأنقاض والمشاهد الديستوبيّة، مسائلَ وجوديّة مضمرة تحت مشاهد الخراب المادّيّ والأخلاقيّ. وهو مفهوم يخرج عن المفهوم التقليديّ لوصف خرائب المدن وبكائيّات أدب مراثي المدن والوقوف على الأطلال؛ إنّه مفهوم يقرأ الركام الصامت من الأحجار من منظور العلاقة الحميميّة مع الأنقاض بصفتها أداة مقاومة وحيدة باقية ضدّ الضياع والمحو القوميّ. وتعتمد هذه المقالة على ثلاثة محاور أساس تصوغ مفهوم دوست للأنقاض؛ الأنقاض وكتابة الذاكرة، والأنقاض: الحدّيّة ومسارات النزوح واللجوء، ونصوص الأنقاض وكتابة السيرة الذاتيّة واليوميّات. وتعيد هذه المقالة النظر في أسئلة التوثيق واللغة والتمثيل والذاكرة، والتي ينبثق منها النقاش في روايات جان دوست، وتحاول معالجة مسألة صياغة التجربة الأليمة وحتّى السوداويّة في أدبه، هذا الأدب الذي يتعامل مع الأنقاض على أنّها أجسام حجريّة متشظّية ذات مدلولات وجوديّة‪.‬
Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity
Authors: Pathak Niramya Jagdish , Singh Abhishek Gajendra , Jain Pavan Surwase , Soni Shailesh Mahendra , Ganpule Arvind Prakash , Sabnis Ravindra Bhalchandra , Desai Mahesh Ramanlal 
Published: September 2022

Abstract
Background
Among adult malignant tumors, renal cell carcinoma accounts for 2–3% and has the worst prognosis among common urologic tumors. Recently, an eosinophilic, solid and cystic (ESC) renal cell carcinoma (RCC) histological subtype has been described and proposed as an entity separate than the 16 subtypes described in the 2016 WHO classification. The aim of the present study is to share our experience of three such cases of this newly described entity.

Methods
We retrospectively reviewed our cases of renal cell carcinoma and describe the presentation, diagnosis and management with follow-up details of ESC RCC.

Results
Our three patients presented at an advanced stage with flank pain or mass, and one patient had metastasis. All patients underwent radical nephrectomy, diagnosis proved by histopathological examination with immunohistochemistry (IHC), with abundant eosinophilic cytoplasm in all three cases. On IHC, CK 20 was positive in two cases and one patient with CK 20, CK 7 negative and PAX 8 positive.

Conclusions
ESC RCC is a newly described entity, with increasing incidence probably due to better diagnosis. Previously, 66 such cases are described, with female predominance, lower stage and indolent behavior. Only four cases with metastasis are described.
Holmium laser enucleation of the prostate: a 3-year single-center experience of 173 cases
Authors: Banga-Mouss Roland B. , Briffaux Raphaël , Damba Joseph Junior , Charles Thomas , Puichaud Alexis , Robin Humphrey , Angermann Edwin , Pires Christophe , Odzebe Anani W. Severin , Ouaki Charlie 
Published: September 2022

Abstract
Background
Holmium laser enucleation of the prostate (Holep) is a safe, effective, and prostate size-independent procedure for benign prostatic hyperplasia treatment (BPH). Holep has demonstrated comparable long-term outcomes with historical BPH mainstay treatments, namely open prostatectomy or transurethral resection of the prostate, as well as straightforward evidence of its low morbidity. In this study, we aimed to report our 3-year Holep experience based on 173 patients.

Methods
We conducted a retrospective descriptive single center study utilizing medical charts of 173 patients who underwent Holep between 2017 and 2020. Peri and postoperative measures included prostate volume, peak urinary flow rate (Qmax), prostate specific antigen, catheterization time, hospital stay, and complications.

Results
The mean age and mean prostate weight at baseline were 71.3 ± 7.8 years and 64.2 g (17 and 380 g), respectively. Holep was associated with a short catheterization time and hospital stay (2.7 and 3 days, respectively). Qmax significantly improved after Holep (8.1 vs 20.4 ml/s, p < 0.05), and results sustained at 06 months postoperatively. Perioperative and postoperative complications were mainly represented by hematuria (29%). However, more than half of these patients were taking anticoagulation drug therapy at the time of surgery. Complications mostly occurred during the early years following Holep’s introduction and tended to decrease with time and experience.

Conclusion
Holep remains a safe and effective procedure for BPH treatment, with durable long-term results even in clinical settings where the procedure is new. The rate of complications, which is associated with the learning curve, improves with time and experience.
Ensemble learning for predicting ex vivo human placental barrier permeability
Authors: Chou Che-Yu , Lin Pinpin , Kim Jongwoon , Wang Shan-Shan , Wang Chia-Chi , Tung Chun-Wei 
Published: September 2022

Abstract
Background
The placental barrier protects the fetus from exposure to some toxicants and is vital for drug development and risk assessment of environmental chemicals. However, in vivo experiments for assessing the placental barrier permeability of chemicals is not ethically acceptable. Although ex vivo placental perfusion methods provide good alternatives for the assessment of placental barrier permeability, the application to a large number of test chemicals could be time- and resource-consuming. Computational prediction models for ex vivo placental barrier permeability are therefore desirable.

Methods
A total of 87 chemicals and corresponding 1444 physicochemical properties were divided into training and test datasets. Three types of algorithms including linear regression, random forest, and ensemble models were applied to develop prediction models for ex vivo placental barrier permeability.

Results
Among the tested models, the ensemble model integrating the previous two methods performed best for predicting ex vivo human placental barrier permeability with correlation coefficients of 0.887 and 0.825 when considering the applicability domain. An additional test on seven newly curated chemicals from the literature showed a good correlation coefficient of 0.879 which was further improved to 0.921 by considering the variation of experiments.

Conclusion
In this study, the first valid predicting model for ex vivo human placental barrier permeability was developed following the OECD guideline. The model is expected to be useful for assessing the human placental barrier permeability and can be integrated with developmental toxicity prediction models for investigating the toxic effects of chemicals on the fetus.
Clinical factors associated with cerebral autoregulation in ischemic stroke related to small artery occlusion
Authors: Wu Xiaohong , Zhou Yanxia , Qi Wenwei , Shen Yanxia , Lei Zhihao , Xiao Kun , Zhang Pandeng , Liu Jia , Ren Lijie 
Published: September 2022

Abstract
Background
Existing data suggest that cerebral autoregulation (CA) varies among different subtypes of ischaemic stroke. CA is globally impaired in patients with small artery occlusion (SAO). However, the factors influencing CA impairment in patients remains to be elucidated.

Methods
Stroke patients with SAO who underwent brain magnetic resonance imaging (MRI) were prospectively studied. Within 7 days after stroke onset, CA was recorded from the middle cerebral artery blood flow velocity and arterial blood pressure was simultaneously measured. Transfer function analysis was used to derive CA parameters, including gain and phase. Clinical characteristics, mean arterial pressure (MAP), biochemical findings, and cerebral small vessel disease (CSVD) markers on MRI were assessed in each patient. Factors associated with CA parameters were investigated. Univariate and multivariate linear regression analyses were conducted to determine the relationship between clinical factors and CA parameters.

Results
Sixty-three SAO patients (age, 56.3 ± 9.9 years; 55 men) were enrolled in the study. In the multiple linear regression analysis, after controlling for relevant clinical factors, MAP on admission (ipsilateral OR = 0.99 and contralateral OR = 0.99, both P < 0.005) was a significant independent predictor of bilateral gain. MAP > 105 mmHg on admission (OR = 0.77, P = 0.019) was significantly associated with ipsilateral gain. Diabetes mellitus was a significant predictive factor for bilateral gain (ipsilateral OR = 1.32 and contralateral OR = 1.22, both P < 0.005). No correlations were found between CA parameters and CSVD characteristics.

Conclusion
In SAO-related ischaemic stroke, patients with MAP > 105 mmHg on admission tended to have better ipsilateral CA. Diabetes mellitus appears to be an independent risk factor for CA impairment in patients with SAO-related stroke. CSVD may not be the main factor affecting bilateral CA in patients with SAO.
Investigating the effect of self-management program on stroke’s patients’ self-efficacy
Authors: Amiri Fereshteh Shalforoosh , Abolhassani Shahla , Alimohammadi Nasrollah , Roghani Tayebeh 
Published: September 2022

Abstract
Background and aim
Stroke patients face various challenges that affect their self-efficacy. The purpose of this study is to evaluate the effect of a self-management program on the self-efficacy of patients with Stroke.

Methods and materials
This study is a clinical trial, in which 72 patients with stroke participated in this study. They were selected based on the convenience sampling method and assigned to either intervention or control group (36 patients in each group) randomly. The intervention group received 5A based self-management program for 6 weeks (in-person and off-site) and the control group received only routine care includes stroke training booklets and post-discharge care training by the ward nurse. Data were collected through demographic and jones self-efficacy questionnaires, before, immediately after, and 3 months after interventions in both groups and were analyzed with descriptive and analytical statistics using SPSS software (with independent t-test, Chi-square, Fisher and analysis of variance with repeated measures with a significance level of 0.05).

Results
Before interventions, the two study groups had no statistically significant difference regarding demographic variables and the mean score of self-efficacy. Immediately and 3 months after interventions, the mean score and mean changes of self-efficacy score in the intervention group were significantly greater than in the control group(p < 0.001).

Conclusion
The results of the present study show the appropriate effect of self-management program on self-efficacy of stroke patients. These results can be used by different members of healthcare teams to improve patients’ self-efficacy.

Trial registration
This study is registered by Iranian Registry of Clinical Trials with decree code: IRCT20190712044181N2 (registration date: 05-11-2019).
Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer
Authors: Liu Tong , Zhang Qingsong , Wang Yiming , Ma Xiangming , Zhang Qi , Song Mengmeng , Cao Liying , Shi Hanping 
Published: September 2022

Abstract
Background
No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population.

Methods
In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models.

Results
During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively.

Conclusions
Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
A healthy lifestyle text message intervention for adolescents: protocol for the Health4Me randomized controlled trial
Authors: Raeside Rebecca , Spielman Karen , Maguire Sarah , Mihrshahi Seema , Steinbeck Katharine , Kang Melissa , Laranjo Liliana , Hyun Karice , Redfern Julie , Partridge Stephanie R. ,   the Health4Me Team, Hackett Maree L. , Figtree Gemma , Gallagher Robyn , Sim Kyra A. , Usherwood Tim , Hepse Charlotte , Skinner John , Champion Katrina E. , Gardner Lauren A. , Williams Kathryn , Castles Danielle 
Published: September 2022

Abstract
Background
Adolescence presents a window of opportunity to establish good nutrition and physical activity behaviours to carry throughout the life course. Adolescents are at risk of developing cardiovascular and other chronic diseases due to poor the complex interplay of physical and mental health lifestyle risk factors. Text messaging is adolescents main form of everyday communication and text message programs offer a potential solution for support and improvement of lifestyle health behaviours. The primary aim of this study is to determine effectiveness of the Health4Me text message program to improve adolescent’s physical activity or nutrition behaviours among adolescents over 6-months, compared to usual care.

Methods
Health4Me is a virtual, two-arm, single-blind randomised controlled trial, delivering a 6-month healthy lifestyle text message program with optional health counselling. Recruitment will be through digital advertising and primary care services. In total, 390 adolescents will be randomised 1:1 to intervention or control (usual care) groups. The intervention group will receive 4–5 text messages per week for 6-months. All text messages have been co-designed with adolescents. Messages promote a healthy lifestyle by providing practical information, health tips, motivation and support for behaviour change for physical activity, nutrition, mental health, body image, popular digital media and climate and planetary health. Virtual assessments will occur at baseline and 6-months assessing physical health (physical activity, nutrition, body mass index, sleep), mental health (quality of life, self-efficacy, psychological distress, anxiety, depression, eating disorder risk) and lifestyle outcomes (food insecurity and eHealth literacy).

Discussion
This study will determine the effectiveness of a 6-month healthy lifestyle text message intervention to improve physical activity and nutrition outcomes in adolescents.

Trial registration
Australia New Zealand Clinical Trials Registry (ANZCTR) ACTRN12622000949785, Date registered: 05/07/2022.
Predictors of colorectal cancer screening intention based on the integrated theory of planned behavior among the average-risk individuals
Authors: Maheri Mina , Rezapour Baratali , Didarloo Alireza 
Published: September 2022

Abstract
Background
This study aimed to determine the predictors of colorectal cancer screening intention based on the integrated theory of planned behavior among average -risk individuals in Urmia. Identifying these predictors will help design and implement various interventions, including educational interventions, according to the needs of this group, thereby taking a step towards improving the colorectal cancer screening index.

Methods
The present cross-sectional study was performed on 410 individuals at average risk of colorectal cancer referring to the comprehensive health services centers of Urmia in Iran. The data collection tool was a researcher-made questionnaire consisting of two parts. The first part captured the demographic information and medical history of the participants. The second part involved questions designed based on constructs of motivational phase of health action process approach, and theory of planned behavior, as well as behavioral intent to perform colorectal cancer screening. Data analysis was performed using SPSS software.

Results
Outcome expectancies, risk perception, action self-efficacy, and normative beliefs, respectively had the largest impact and were significant and positive predictors of colorectal cancer screening intention. The study’s conceptual framework explained about 36% of the variance of behavioral intention among the average-risk individuals in Urmia.

Conclusions
Constructs of motivational phase of health action process approach, and theory of planned behavior are valuable and appropriate to identify the factors affecting the intention to undergo colorectal cancer screening as well as to design and implement educational interventions in this field. The four constructs of outcome expectancies, risk perception, action self-efficacy, and normative beliefs are suggested to be integrated into all educational interventions designed and implemented to improve the colorectal cancer screening index.