bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-sarcoma characterization of lncRNAs in the crosstalk of EMT and tumor immunity identifies distinct clinical outcomes and potential implications for immunotherapy
Authors: Shi Deyao , Mu Shidai , Pu Feifei , Zhong Binlong , Hu Binwu , Shao Zengwu , Zhang Zhicai , Liu Jianxiang 
Published: April 2022

Abstract
The epithelial-to-mesenchymal transition (EMT) is a reversible process that may interact with tumor immunity through multiple approaches. Increasing evidence has demonstrated the interconnections among EMT-related processes, tumor microenvironment, immune activity, as well as the potential influence on immunotherapy response. Long non-coding RNAs (lncRNAs) are emerging as critical modulators of gene expression. They can play fundamental roles in tumor immunity and act as promising biomarkers of immunotherapy response. However, the potential roles of lncRNA in the crosstalk of EMT and tumor immunity are still unclear in sarcoma. We obtained multi-omics profiling of 1440 pan-sarcoma patients from 19 datasets. Through an unsupervised consensus clustering approach, we categorized EMT molecular subtypes. We subsequently identified 26 EMT molecular subtype and tumor immune-related lncRNAs (EILncRNA) across pan-sarcoma types and developed an EILncRNA signature-based weighted scoring model (EILncSig). The EILncSig presented a favorable performance in predicting the prognosis of sarcoma, and the high-EILncSig was associated with exclusive TME characteristics with desert-like infiltration of immune cells. Multiple altered pathways, somatically mutated genes and recurrent CNV regions associated with EILncSig were identified. Notably, the EILncSig was associated with the efficacy of immune checkpoint inhibition (ICI) therapy. We additionally screened compounds such as Irinotecan that may have the potential to convert the EILncSig phenotype. By integrative analysis on multi-omics profiling, our findings provide a comprehensive resource for understanding the functional role of lncRNA-mediated immune regulation in sarcomas, which may advance the understanding of tumor immune response and the development of lncRNA-based immunotherapeutic strategies for sarcoma.
An improved Rational Bezier model for pneumatic constant force control device of robotic polishing with hysteretic nonlinearity
Authors: chen yongjiang , Zhao jianghai , Jin Yujie 
Published: April 2022

Abstract
The pneumatic constant force control device has been widely used in robot deburring, sanding, polishing, and other fields due to its good flexibility, simple control, and low cost. The force control accuracy of the pneumatic constant force system could be greatly affected by its nonlinear hysteresis characteristics in the process from the cylinder input to the force output at the end of the device. A Rational Bezier based state fitting method (BSFM) has been presented for calibrating the inherent nonlinearity of the low-cost pneumatic constant force system. Compared with the most widely used PSFM, which is a Polynomial based state fitting method, the BSFM could calibrate the strong inherent nonlinearity of the system more smoothly with the lower ordered model and in a continuous form rather than the piecewise form of the PSFM. The BSFM could maintain a balance between simplicity and precision. Through a series of comparative experiments with different contact forces and feed rates, the proposed method has smaller force overshoot and when active force control is turned on the force variation is greatly reduced to less than 2 N. The average roughness of the workpiece reached 0.4 µm after polishing.
High-Temperature Flexible WSe2 Photodetectors with Ultrahigh Photoresponsivity
Authors: Zou Yixuan , Zhang Zekun , Yan Jiawen , Lin Linhan , Huang Guan-Yao , Li Peng 
Published: April 2022

Abstract
Industries such as aerospace or military have promoted the development of high-temperature photodetectors. However, current high-temperature photodetectors exhibit low photoresponsivity (<10 A/W) because heat resistant materials usually have poor optical sensitivity. 2D transition metal dichalcogenides demonstrate outstanding optoelectronic properties, but they cannot survive at elevated temperature. It is challenging to realize photodetector with both high-temperature-resistant capability and high photoresponsivity. Here, we report WSe2 photodetector which can endure record high temperature of 700 ℃ in air (1000 ℃ in vacuum). It is the most heat resistant 2D-material device ever reported. Graphene/h-BN heterostructure with atomically flat interface is the key for high-temperature protection. Unconventional negative photoconductivity (NPC) phenomenon appears at high temperature. Operated in NPC mode, the device exhibits photoresponsivity of 2.2×106 A/W, which is ~105-fold higher than that of state-of-the-art high-temperature photodetectors, and even higher than that of existing WSe2 photodetectors. Furthermore, current high-temperature photodetectors are rigid, which limits their applications. Our device demonstrates excellent flexibility, making it highly adaptive to various shaped surfaces. Our approach can be extended to other 2D materials and may stimulate the research of novel 2D-material devices working in harsh environment.
The Effects of Lower Extremity Static Muscle Fatigue on Balance Components
Authors: AKYILDIZ Can , SÖZEN Hasan 
Published: April 2022

Abstract
Background: The body exhibits dynamic and static movements in response to the changes in the center of gravity in some positions. Balance plays a key role in all sports branches and daily life because it can control the lowest energy consumption and muscle activation. Objectives: This study investigated the effects of lower extremity static muscle fatigue on static and dynamic balance components. Design/Methods: The sample consisted of 40 healthy volunteers aged 18-24 years. Participants took part in an isometric fatigue protocol for lower extremity muscles. A squat position was used for static fatigue for lower extremity muscles. Measurements were performed in a squat press for 25 seconds, with the knee at a 90-degree angle and a load of about 30% of the participant's weight isometrically. The protocol was repeated five times. The participant was allowed to rest for two minutes between each repetition. The muscles and their antagonists that contracted most actively during the squat press exercise were vastus lateralis obliquus, rectus femoris, tibialis anterior, biceps femoris, semi tendineus, and lateral gastrocnemius. Electromyography (EMG) measurements were conducted on these muscles bilaterally and motion analysis system was used to standardize the 90-degree angle of the knee joint. Results: There was a significant difference between pre-test and post-test Eyes Open (EO) static balance scores, pre- and post-exercise posttest dynamic balance scores between non-athletes and athletes, pre- and post-exercise posttest dominant leg EO, and pretest non-dominant leg between non-athletes and athletes (p<.05). There was a significant difference in the MF (Hz) values of the dominant leg agonist rectus femoris (p<.05) and the antagonist muscle semi tendineus (p<.05) scores during isometric squat press between athletes and non-athletes. There were statistically significant differences in the co-fatigue (coordinated fatigue) scores of the dominant leg agonist and antagonist muscle groups between non-athletes and athletes during isometric squat press (p<.05). Conclusions: we need different applications to understand the mechanisms underlying balance and discover athletes' potential. Lower extremity proprioception exercises have positive effects on static body balance parameters, and a co-fatigue index can help us investigate co-fatigue, especially during isometric effort at different knee joint angles and different joints.
The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation
Authors: Zhu Zhu , Qian Chenyue , Su Cunjing , Tao Hong , Mao Jiaojiao , Guo Zhening , Zhu Xinyi , Pan Jie 
Published: April 2022

Abstract
Aims: This study aimed to analyze associations between genetic variants and plasma concentrations along with clinical outcomes in dabigatran in patients with non-valvular atrial fibrillation (NVAF).Methods: We conducted a prospective study and enrolled NVAF patients treated with dabigatran in the real world. A total of 86 patients treated with 110 mg DE twice daily were recruited for this study. Blood samples were obtained from each patient and used for genotyping and determination of plasma dabigatran concentration. All bleeding and thromboembolic complications were recorded during the 1.5 years of follow-up.Results: Eighty-three patients provided samples at the trough plasma level of dabigatran, and 58 patients provided samples at the peak plasma level of dabigatran. There was a significant association between the CES1 SNP rs8192935 and trough plasma concentrations of dabigatran (P=0.013). The ABCB1 SNP c.2482-2236G>A (rs4148738) was associated with major bleeding events in the addictive model (P=0.046, OR=3.29) and dominant model (P=0.040, OR=8.17). Additionally, the ABCB1 SNP c.3435C>T (rs1045642) was associated with the incidence of major bleeding events in the addictive model (P=0.043, OR=3.34) and dominant model (P=0.046, OR=7.77). However, no significant associations were found between all the SNPs and the incidence of minor bleeding events.Conclusions: Our results indicated that the CES1 polymorphism rs8192935 was associated with trough plasma concentrations of dabigatran. Carriers of the G allele had increased trough plasma concentrations of dabigatran compared to noncarriers. The ABCB1 polymorphisms rs4148738 and rs1045642 were associated with an increased risk for major bleeding events for the first time in a Chinese population.
Tuning the nonlinear optical properties of quantum dot by noise-anharmonicity interplay
Authors: Roy Debi , Md. Sk. , Ghosh Manas 
Published: April 2022

Abstract
Present study executes a thorough enquiry of tailoring a few important nonlinear optical (NLO) properties of
GaAs quantum dot (QD) by invoking Gaussian noise-anharmonicity interplay. The NLO properties enquired are total optical absorption coefficient (TOAC), total optical refractive index change (TORIC), nonlinear optical rectification
(NOR), second harmonic generation (SHG), third harmonic generation (THG), DC-Kerr effect (DCKE), electro-absorption coefficient (EAC), group index (GI) and optical gain (OG). The mode of entry of noise (additive/multiplicative) to the QD, in conjunction with the symmetry (odd/even) of the anharmonicity, design the above NLO properties. These NLO properties have been found to be endowed with regular rise, regular decline, maximization, minimization and saturation. The findings of the study emerge quite prolific owing to the profound technological need of QD, particularly when it consists of anharmonicity and under the influence of noise.
Formulation process, physical stability and herbicidal activities of Cymbopogon nardus essential oil-based nanoemulsion
Authors: Somala Naphat , Laosinwattana Chamroon , Teerarak Montinee 
Published: April 2022

Abstract
Essential oil-based bioherbicides are a promising avenue for the development of eco-friendly pesticides. This study formulated nanoemulsions containing citronella (Cymbopogon nardus) essential oil (CEO) as an herbicidal product using a high-pressure homogenization method with hydrophilic-lipophilic balance (HLB) values ranging 9-14.9 for the surfactant mixture (Tween 60 and Span 60). The CEO was high in monoterpene compounds (36.333% geraniol, 17.881% trans-citral, 15.276% cis-citral, 8.991% citronellal, and 4.991% β-citronellol). The nanoemulsion at HLB 14 was selected as optimal due to having the smallest particle size (78.8 nm, PI 0.286), confirmed by transmission electron microscopy. After 28 days of storage, particle size in the selected formulation changed to 57.9 and 139.8 nm under 4°C and 25°C, respectively. Germination and seedling growth assays with Echinochloa crus-galli showed that the nanoemulsion exerted a significant dose-dependent inhibitory effect at all tested HLBs (9-14.9) and concentrations (100–800 µL/L). The inhibitory effect was greatest at HLB 14. Treatment of E. cruss-galli seed with the HLB 14 nanoemulsion significantly reduced seed imbibition and α-amylase activity. Our findings support that CEO nanoemulsions have a phytotoxic effect and hence herbicidal properties for controlling E. cruss-galli. Accordingly, this nanoemulsion may have potential as a bioherbicide resource.
Correlation of Automated Breast Volume Scanner Imaging and the Difference of Molecular Subtypes Between Core Needle Biopsy and Surgical Specimens
Authors: Wang Dandan , Li Yating , Sun Hui , Xu Chaoli , Yang Bin 
Published: April 2022

Abstract
Background: Core needle biopsy (CNB) and automated breast volume scanner (ABVS) play crucial roles in diagnosing breast cancer. However, the molecular subtype of breast cancer in CNB and surgery is a paradox at times. Analyzing the correlation between ABVS and the difference of molecular subtypes between CNB and surgery specimens has not been reported. The purpose of this study is to identify the characteristics of ABVS imaging that affect the discrepancy of molecular subtypes between CNB and surgical specimens in breast cancer patients.Methods: Eighty-two breast cancer patients (83 lesions) who underwent ABVS examinations were enrolled at Jinling Hospital between November 2014 to October 2020. The molecular subtypes (luminal A, luminal B (HER-2 positive), luminal B (HER-2 negative), HER-2 overexpression, and triple-negative subtypes) and the discrepancy rate of the specimens via CNB and surgery were determined. The clinicopathological and ABVS imaging features were compared between the discrepancy group (molecular subtypes were different between CNB and surgery specimens) and the consistency group (molecular subtypes were concordant between CNB and surgery specimens). Receiver operating characteristic (ROC) curves were plotted for the diagnostic performance of the significant features. Results: Of the 83 lesions, a concordance rate of 73.5% (κ=0.64) was shown between the CNB specimens and the surgical specimens for molecular subtypes. The presence of clear boundary, irregular shape, well-defined margin, and no retraction phenomenon on ABVS were independently associated with discrepancy in molecular subtypes (all P < 0.05). The area under the curve (AUC) for the combination of these four features on ABVS was 0.9 (95% CI:0.8-0.9), yielding a sensitivity and specificity of 100% and 41%, respectively.Conclusions: ABVS is feasible with excellent sensitivity in determining the discrepancy of molecular subtypes between specimens via CNB and surgery. Multipoint puncture during CNB should be advocated for the lesions with the presence of clear boundary, irregular shape, well-defined margin, and lack of retraction phenomenon, thus leading to avoidance of discrepancy in molecular subtypes in clinical diagnosis and treatment processes in breast cancer patients.
Association of retinol and carotenoids content in diet and serum with risk for Colorectal cancer: a meta-analysis
Authors: Han Xiaoyong , Zhao Rangyin , Zhang Guangming , Jiao Yajun , Wang Yongfeng , Wang Da , Yang Kehu , Cai Hui 
Published: April 2022

Abstract
Background: Colorectal cancer (CRC) risk is linked to serum and dietary retinol and carotenoids, according to clinical and epidemiological research. However, the findings are not consistent. As a result, we did this meta-analysis to determine the link between them.Methods: From 2000 through 2022, the PubMed, Web of Science, and Embase databases, as well as pertinent article references, were searched and filtered based on inclusion and exclusion criteria and literature quality ratings. High and low intake were used as controls, and OR (odds ratio) or RR (relative risk) and 95% confidence interval were extracted. The extracted data were plotted and analyzed using Stata12.0 software.Results: A total of 22 relevant studies were included, including 18 studies related to diet and 4 studies related to serum. For high and low intake or concentration controls, the pooled OR was as follows: β-carotene (OR = 0.89, 95% CI: 0.78-1.03), α-carotene (OR = 0.87, 95% CI: 0.72 – 1.03), lycopene (OR = 0.93, 95% CI: 0.81 – 1.07), lutein/zeaxanthin (OR = 0.96, 95% CI: 0.87 – 1.07), β-cryptoxanthin (OR = 0.70, 95% CI: 0.54 – 0.90), total carotenoids (OR = 0.97, 95% CI: 0.81-1.15), retinol (OR = 0.99, 95% CI: 0.89 – 1.10)，serum carotenoids (OR = 0.73, 95% CI: 0.58 – 0.93), serum retinol (OR = 0.62, 95% CI: 0.26 – 1.49). Subgroup analysis was performed according to tumor type, study type and sex.Conclusions: Dietary intake of β-cryptoxanthin significantly reduced CRC risk and dietary β-carotene considerably decreased CRC risk in the male group. Alternatively, serum carotenoid concentrations were significantly inversely associated with CRC risk.
Experiences That Matter in Bipolar Disorder: A Qualitative Study Using the CCC Framework
Authors: Sharp Steven , Ulack Christopher , Chiang Karl , Scalea Teresa Lanza Di , O’Hara Sarah , Siegel-Ramsay Jennifer , Strakowski Stephen , Suarez Joel , Teisberg Elizabeth , Wallace Scott , Almeida Jorge 
Published: April 2022

Abstract
Background: Bipolar disorder impacts every domain of living, but treatment is often focused only on core diagnostic symptoms. Care and quality of life can be improved by understanding the experience of people with the condition. Direct interviews with affected individuals offers a unique window into the lived experience of bipolar disorder.Methods: Thirty individuals participated in Experience Group sessions. Researchers conducted individual interviews (n=12) and group sessions (n=18). Audio files were transcribed and NVivo software processed initial thematic analysis. Data was analyzed using the Capability, Comfort, and Calm (CCC) framework of outcomes that matter most to people developed by Teisberg and Wallace (Liu et al. 2017; Teisberg et al. 2020).Results: Themes identified in the CCC framework included the struggle to maintain identity, employment disruptions, relationship loss, unpredictable nature of bipolar disorder, personal perception of diagnosis, social stigma, identifying appropriate medication medication, managing dismissive doctors, finding the right psychotherapist and navigating financial burden. Limitations: Limitations of our study include a small sample size and length of interview time. Researchers also had limited information about participants’ diagnoses and comorbidities. Conclusions: Qualitative data about bipolar disorder helps identify aspects of care and quality of life that are overlooked when focusing only on core diagnostic symptoms. Improved outcomes could be achieved by implementing care based on the lived experiences of people with bipolar disorder.
Physiological responses of rye seedlings to the combined stress of NaCl, ambrosia and freeze-thaw
Authors: Zhang Wei , Bao Guozhang , Liu Jiapeng , Xiao Jing , Dai Gejun , Wang Zhao , Yang Yinan , Xi Jinghui , Zhang Xin , Li Guomei , Zhao Hongwei 
Published: April 2022

Abstract
Background: Crops are often affected by NaCl, ambrosia and freeze-thaw stress simultaneously during their growth, and many areas in Northeast China are facing such serious ecological stress problems. In this experiment, the physiological responses of rye seedlings to NaCl and ambrosia stress in a freeze-thaw environment were studied by artificial simulation technique. Malondialdehyde (MDA) content, soluble protein (SP) content, superoxide dismutase (SOD) activity, catalase (CAT) activity, net photosynthetic rate (Pn) and transpiration rate (Tr) were determined and analyzed. Results: The results showed that: After stress treatment, MDA and SP contents of rye seedlings increased by 19.48%-88.96% and 22.54%-107.30%, SOD and CAT activities increased by 4.42%-26.60% and 23.31%-64.68% and Pn and Tr decreased by 40.00%-71.67% and 20.00%-80.00%. Conclusion: In the face of stress, rye seedlings can reduce the damage caused by stress by increasing osmotic substance and antioxidant enzyme activity, so as to achieve the purpose of adapting to environment. The results revealed that combined NaCl, ambrosia and freeze-thaw stress had a significant superposition effect on plants compared with single NaCl, ambrosia and freeze-thaw stress.
Influence of machining parameters in longitudinaltorsional ultrasonic vibration milling titanium alloy for milling force
Authors: Zhao Mingli , Zhu Junming , Song Shijie , Xue Boxi , Zhao Bo 
Published: April 2022

Abstract
To study the effect of different parameters on milling force for longitudinal torsional ultrasonic vibration milling (LTUM) of titanium alloy, the kinematic theory of LTUM is combined with the model of milling transient cutting thickness to establish the milling force equation, and experiment was carried out. The experimental results showed that: Milling force was positively correlated with cutting speed, cutting depth, feed per tooth (milling force increased by about 40% in increasing the cutting speed from 40m/min to 100m/min, 300% in increasing the depth of cut from 0.1mm to 0.4mm, and 25% in increasing the feed per tooth from 0.01mm to 0.04mm). Milling force was negatively correlated with ultrasonic amplitude, tool helix angle (milling force reduced by about 22% in increasing the ultrasonic amplitude from 1µm to 4µm, and 23% in increasing the tool helix angle from 30° to 45°). The milling force was minimized when the ultrasonic amplitude was 4 µm, cutting speed was 60 m/min, cutting depth was 0.1 mm, feed per tooth was 0.01 mm/z, and tool helix angle was 40°. In further, the empirical model of milling force was established and accuracy was verified by experimental data.
Evaluating water use advantage of wheat-maize relay intercropping under rainfed condition using an improved approach
Authors: Ma Longshuai , Li Yinjuan , Wu Pute , Zhao Xining , Chen Xiaoli , Gao Xiaodong 
Published: April 2022

Abstract
Accurately assessing water consumption and water use efficiency in intercropping systems relative to sole crop systems is important for planting system planning. This study was conducted to improve water use evaluation method for wheat/maize (Triticum aestivum L./Zea mays L.) intercropping under rainfed conditions. Field experiments were conducted from 2014 to 2016 in Yangling, Shanxi Province, China. Three cropping patterns were tested: sole wheat, sole maize, wheat/maize intercrops. Method for evaluating water use advantage in intercropping was improved by considering water consumption of sole crops during the fallow period. Results showed that intercropping grain yield was higher than sole cropping yield. Before revising the water use period to account for water use during the non-crop period, the intercropping system had 20.3% greater water use, but 18.7% lower water use efficiency than the sole cropping system. After the revision accounting for non-growth period water use, intercropping had 8.1% less water use than sole cropping, and 5.3% greater water use efficiency. After revising the water use period, intercropped wheat used 24.5% less water and the intercropped maize used 11% more water than the corresponding sole crops, and the water use efficiency of intercropped wheat was 32.4% greater than sole wheat water use efficiency. The revised method accounting for water use during the non-growth portion of the crop production season resulted in a more objective evaluation of water utilization in the intercropping system. Wheat/maize intercropping increased both yield and water use efficiency, which is especially important for areas with limited water.