bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANÁLISE DO REFLEXO DA INSCRIÇÃO DE RESTOS A PAGAR NO RESULTADO PRIMÁRIO DOS MUNICÍPIOS PERNAMBUCANOS.
Authors: Ribeiro Marcelo Victor José de Barros , Janiszewski Vanessa , LOPES LEANDRO DA COSTA , Lagioia Umbelina Cravo Teixeira 
Published: September 2022

<p>O objetivo deste trabalho é analisar o reflexo da inscrição de restos a pagar no resultado primário nos municípios pernambucano. A abordagem metodológica se dará com análise de dados baseada em regressão com dados em painel. Os resultados da regressão revelaram que a inscrição em restos a pagar contribuem na diminuição do resultado primário dos municípios pernambucanos. O modelo explica 54,72% das variações no resultado primário dos municípios pernambucanos de 2014 a 2017, explicando ainda, 3,09% das variações do mesmo indicador entre os municípios e, num contexto geral, explica 18,18% do comportamento do indicador da educação ao longo do tempo e entre os municípios. Dentre as variáveis estudadas as que mais influenciam no resultado primário são: Inscrição em restos a pagar não processados, inscrição em restos a pagar processados, despesas com investimento, outras despesas correntes, despesas com pessoal, receitas oriundas do fundo de participação dos municípios, bem como receitas tributárias.</p>
GESTÃO POR COMPETÊNCIAS EM INSTITUIÇÕES FEDERAIS DE ENSINO: ESTUDO COMPARATIVO NO IFSC, IFC E IFSP
Authors: Dalmau Marcos B. L. , Furlan Loana De Moura , Mendes Ketty Celina Fernandes , Junior Geraldo Tessarini 
Published: September 2022

<span>Atualmente, as organizações públicas enfrentam um cenário de desafios, ocasionados pelo aumento das exigências da sociedade por serviços públicos de melhor qualidade. Isto exig</span><span>e que as organizações públicas e seus servidores desenvolvam competências que possibilitem aumentar o seu potencial. Esses desafios também se fazem presentes nas Instituições Federais de Ensino (IFEs), as quais buscam implementar a Gestão por Competências desde 2006, com a Política Nacional de Desenvolvimento de Pessoal (PNDP), instituída pelo Decreto n. 5.706/06 e reformulada pelo Decreto n. 9.991/19. O presente estudo teve como objetivo identificar e analisar as políticas e ações que visem ao desenvolvimento das competências dos servidores em três IFEs - IFSP, IFC e IFSC. Para tanto, foi utilizada a pesquisa descritiva, com abordagem qualitativa e análise comparativa, sendo a coleta de dados feita em bibliografias, legislações e em documentos institucionais de acesso público. Os resultados indicam que as instituições buscam ações e linhas de desenvolvimento de competências semelhantes. Com exceção do IFSC, percebe-se que não há indicativos de que as instituições promovam o alinhamento estratégico de suas ações com mapeamento das competências. Apesar disso, algumas ações positivas destacam-se, como a redução da jornada de trabalho concedida pelo IFSP e o estabelecimento de um percentual mínimo para investimento em capacitação no âmbito do IFC.</span>
25 let razvoja informatike skozi prizmo konference OTS
Authors: Pavlič Luka 
Published: September 2022

»	Sodobne informacijske tehnologije in storitve«) na nek način predstavlja rdečo nit IT strokovnjakov širše regije že več kot četrt stoletja. Dogodek, kjer strokovnjaki predstavljajo svoje uspešne projekte, izmenjujejo bogate izkušnje iz prakse, identificirajo morebitne prihodnje trende, ter krešejo mnenja o dogajanju v industriji že petindvajsetič, posledično predstavlja pomemben dokument o vsakoletnem stanju informatike v ožji in širši regiji. Konferenca OTS tako skozi svojo zgodovino ponuja ne samo zanimive vpoglede v duh časa, temveč vsakokrat nudi tudi zanimiv in kritičen vpogled v prihodnost področja. Članek ponuja vpoglede v vsakoletne zbornike, ki preko člankov omogočajo dokaj verodostojno rekonstrukcijo prevladujočih pristopov, orodij, mnenj in trendov skozi čas. V članku skozi analizo zbornikov identificiramo vzpone in padce tehnologij, pristopov in dobrih praks iz industrije. Ugotovili bomo, da smo določene izzive že uspeli rešiti, določeni pa žal ostajajo, čeprav se jih lotevamo vedno znova z drugačnimi pristopi in orodji.
Maastrichtian atmosphericpCO2 and climatic reconstruction from carbonate paleosols of the Marília Formation (southeastern Brazil)
Authors: Menezes Maurícius Nascimento , Dal' Bó Patrick Führ , Smith Jon J. , Rodrigues Amanda Goulart , Rodríguez-Berriguete Álvaro 
Published: September 2022

AbstractPaleosols are the product of ancient physical, chemical, and biological processes on the Earth's surface and, as such, may record information that can be used to reconstruct the paleoatmospheric and paleoenvironmental conditions under which they formed. In Brazilian continental sedimentary successions, few studies using ancient soils have focused on the relationship between paleopedogenesis and paleoclimate. The Marilia Formation is a 160-m-thick section of the Bauru Basin in which ∼ 66% of the deposits show some evidence of pedogenic modification as paleosols. In this paper, paleosol profiles in the Marilia Formation containing thick calcrete intervals are described and attributed to three pedotypes: Avencas, Monte Alto, and Garça. Macro and microscopic pedogenic features of each pedotype are described in detail. Moreover, the analysis of clay mineralogy, whole-rock geochemistry, and stable-isotope composition are used to define pedogenic processes, paleoclimate proxies, and atmospheric pCO2 estimates. The Avencas pedotype is composed of six polygenetic profiles with different phases of carbonate precipitation, clay illuviation, and biogenic actions. The Monte Alto pedotype is moderately developed and composed of calcic horizons formed mainly by rhizoliths, with higher degrees of calcification and oxidation compared to Avencas profiles. The Garça pedotype is well developed with five polygenetic profiles presenting high carbonate content and low accumulation of clay minerals (CIA-K) and leaching. Estimates of paleoprecipitation and paleotemperature from the studied paleosols using climofunctions of molar ratio of base to alumina, depth of carbonate accumulation, salinization, oxygen composition, and paleosol weathering index proxy (PWI) show values ranging from 242 to 718 mm/yr and 11° to 14°, respectively. Climofunction values suggest a paleoclimate of semiarid to subhumid during deposition of the Marília Formation. The climate data also suggests that during the Maastrichtian, the Bauru Basin was geographically within the Southern Hot Arid Belt zone, though showing strong influence of the lower latitudinal Equatorial Humid belt. Furthermore, atmospheric pCO2 values calculated from pedogenic carbonates may correlate with a cooling interval during the latest Maastrichtian (68.5–66.25 My).
Barriers to childhood tuberculosis case detection and management in Cambodia: the perspectives of healthcare providers and caregivers
Authors: An Yom , Teo Alvin Kuo Jing , Huot Chan Yuda , Tieng Sivanna , Khun Kim Eam , Pheng Sok Heng , Leng Chhenglay , Deng Serongkea , Song Ngak , Nonaka Daisuke , Yi Siyan 
Published: September 2022

Abstract
Background
Diagnosis and treatment of tuberculosis (TB) in children remain challenging, particularly in resource-limited settings. Healthcare providers and caregivers are critical in improving childhood TB screening and treatment. This study aimed to determine the barriers to childhood TB detection and management from the perspectives of healthcare providers and caregivers in Cambodia.
Method
We conducted this qualitative study between November and December 2020. Data collection included in-depth interviews with 16 healthcare providers purposively selected from four operational districts and 28 caregivers of children with TB and children in close contact with bacteriological confirmed pulmonary TB residing under the coverage of the selected health centers. Data were analyzed using thematic analyses.
Results
Mean ages of healthcare providers and caregivers were 40.2 years (standard deviation [SD] 11.9) and 47.9 years (SD 14.6), respectively. Male was predominant among healthcare providers (93.8%). Three-fourths of caregivers were female, and 28.6% were grandparents. Inadequate TB staff, limited knowledge on childhood TB, poor collaboration among healthcare providers in different units on TB screening and management, limited quality of TB diagnostic tools, and interruption of supplies of childhood TB medicines due to maldistribution from higher levels to health facilities were the key barriers to childhood TB case detection and management. Caregivers reported transportation costs to and from health facilities, out-of-pocket expenditure, time-consuming, and no clear explanation from healthcare providers as barriers to childhood TB care-seeking. Aging caregivers with poor physical conditions, lack of collaboration from caregivers, ignorance of healthcare provider's advice, and parent movement were also identified as barriers to childhood TB case detection and management.
Conclusions
The national TB program should further invest in staff development for TB, scale-up appropriate TB diagnostic tools and ensure its functionalities, such as rapid molecular diagnostic systems and X-ray machines, and strengthen childhood TB drug management at all levels. These may include drug forecasting, precise drug distribution and monitoring mechanism, and increasing community awareness about TB to increase community engagement.
Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation
Authors: Tao Yilin , Tang Chengyuan , Wei Ju , Shan Yi , Fang Xi , Li Ying 
Published: September 2022

Abstract
Background
Renal interstitial fibrosis (RIF) is a common pathological change in kidney diseases progressing into end-stage renal disease and involves multiple cell types, but the key targets and regulatory mechanisms have not been fully elucidated. Nuclear receptor subfamily 4 group A member 1(Nr4a1) belongs to a subfamily of nuclear receptors, and in this study, we found a regulatory effect of Nr4a1 on p38 MAPK phosphorylation in renal tubular epithelial cells with renal interstitial fibrosis.
Methods
Firstly, we collected human renal fibrosis specimens and used unilateral ureteral obstruction (UUO) mice and transforming growth factor (TGF)-β1-stimulated human renal proximal tubular epithelial cells (HK-2) as in vivo and in vitro models to detect the expression of Nr4a1. Subsequently, using Nr4a1-specific agonist Cytosporone B (Csn-B) in vivo and in vitro and Nr4a1 small interfering RNA in vitro, we observed renal pathological changes by HE and Masson staining, and immunohistochemical staining and western blot were performed to detect the expression of fibronectin (Fn) and collagen-I (Col-I), as well as p38 MAPK phosphorylation level.
Results
The results showed that firstly Nr4a1 expression was upregulated in human fibrosis and UUO mice kidney, and positively correlated with the degree of interstitial kidney injury and fibrotic protein expression. Csn-B aggravated UUO-caused renal interstitial fibrosis and activated p38 MAPK phosphorylation. In vitro it also showed that Nr4a1 expression increased under TGF-β1 stimulation, and transfection with Nr4a1 small interfering RNA reduced the expression of TGF-β1-stimulated Fn、Col-I and p38 MAPK phosphorylation levels. Similary, Csn-B induced Fn、Col-I expression and p38 MAPK phosphorylation in HK-2 cells. Further, p38 MAPK inhibitor SB203580 reversed the Csn-B-induced Fn and Col-I expression. In addition, immunofluorescence and western blot suggested that Csn-B induced increased Nr4a1 expression in the cytoplasm.
Conclusion
The above results indicated that Nr4a1 could exert pro-fibrotic effect by regulating p38 MAPK phosphorylation in renal interstitial fibrosis.
The effect of cellular nuclear function alteration on the pathogenesis of shoulder adhesive capsulitis. An immunohistochemical study on Lamin A/C expression
Authors: Candela Vittorio , Peruzzi Barbara , Leopizzi Martina , Porta Natale , Maio Valeria Di , Rocca Carlo Della , Gumina Stefano 
Published: September 2022

Abstract
Background: The network of intermediate filament proteins underlying the inner nuclear membrane forms the nuclear lamina. A and B-type lamins are the major components of the nuclear lamina. Lamins have been associated with important cellular functions: DNA replication, chromatin organization, differentiation of the cell, apoptosis and in maintenance of nuclear structure.
Little is known regarding the etiopathogenesis of adhesive capsulitis (AC); recently, a dysregulating fibrotic response starting from a subpopulation has been described within the fibroblast compartment that suddenly turns on an activated phenotype.
Considering the key role of A-type lamin in the regulation of cellular stability and function we performed an immunohistochemical analysis to compare the lamin A/C expression between patients with AC and healthy controls.
Materials and methods: Twenty-six patients [12M-14F, mean age (SD): 52.3 (6.08)] were enrolled. Tissue samples excised from the rotator interval were analysed for lamin A/C expression by immunohistochemistry. Controls were represented by samples obtained by normal rotator interval excised from patients submitted to shoulder surgery [6M-9F, mean age (SD): 57.1 (5.3)]. The intensity of staining was graded, and an H-score was assigned. Statistical analysis was performed.
Results: The expression of lamin A/C was found to be significantly lower in the fibroblasts of patients with adhesive capsulitis when compared to controls (intensity of staining: p: 0.005; H-score: 0.034); no differences were found regarding the synoviocytes (p>0.05). Considering only patients with AC, lamin A/C intensity staining was found to be significantly higher in samples where acute inflammatory infiltrate was detected (p: 0.004).
No significant changes in levels of lamin A/C expression were documented between the mild and severe adhesive capsulitis severity groups.
Conclusions: Our study demonstrated that the activity of lamin A/C in maintaining nuclear structural integrity and cell viability is decreased in patients with adhesive capsulitis. The timing of the pathogenetic process is the key factor for cell functionality which is maintained in the early stages of the disease; on the contrary, the clinical severity of adhesive capsulitis plays a marginal role on nuclear stability.
Level of Evidence: III
Oral Nicotinamide Mononucleotide (NMN) to treat chronic insomnia: Protocol for the multicenter, randomized, double-blinded, placebo-controlled trial.
Authors: Gao Xiangyang , Zeng Qiang , Li Junhua , Xu Sanping , Li Xueying , Wang Xicheng , Li Yongli , Huang Yan , Liu Shaohui 
Published: September 2022

Abstract
Background: The treatment of insomnia, which is the most common sleep disorder, includes drug and behavioral treatment, but each treatment measure has its limitations. So new treatment method needs to be taken to improve the treatment effect. MN supplementation is a potential promising new method for the treatment of insomnia, resulting in a rising need for methodological research towards verifying its efficacy.
Methods/Design: We describe a proposal for a multicenter, patient-assessor-blinded, randomized controlled trial with two parallel arms. A total of 400 chronic insomnia patients will be allocated 1:1 to the intervention group (treatment with oral NMN 320mg/day) or control group (treatment with oral placebo). All subjects are clinical chronic insomnia patients who meet all inclusion criteria. All subjects are treated by taking NMN or placebo.
The primary outcome is the score on the Pittsburgh Sleep Quality Index (PSQI). Secondary outcomes are the score on the Insomnia Severity Index (ISI) and Epworth Sleeping Scale (ESS)，the Total sleep time (TST), sleep efficiency (SE), sleep latency, REM sleep latency to assess sleep quality changes.
Subjects are assessed at two time points: baseline and follow-up. The duration of the clinical trial is 60 days.
Discussion: This study will provide more evidence on the effects of NMNon improving sleep quality among patients with chronic insomnia. If proven effective, NMN supplementcan be used as a new treatment for chronic insomniain the future.
Trial registration:
Chinese Clinical Trial Registry (chictr.org.cn): ChiCTR2200058001. Registered on 26 March 2022.
Ubiquitous Spin Freezing in the Superconducting State of UTe2
Authors: Sonier Jeff , Sundar Shyam , Gheidi Shayan , Azari Nasrin , Goeks Mariah , Abedi Mae , Yakovlev Michael , Blundell Stephen , Wilkinson John , Dunsiger Sarah , Rosa Priscila , Thomas Sean , Movshovich Roman , Lee Sangyun , Woods Andrew , Paglione Johnpierre , Saha Shanta , Butch Nicholas , Metz Tristin , Hayes Iain 
Published: September 2022

Abstract
In most superconductors electrons form Cooper pairs in a spin-singlet state mediated by either a quantum of energy from a crystal lattice vibration (phonon) or by long-range interactions such as spin fluctuations. The novel superconductor UTe2 is a rare material wherein electrons form pairs in a unique spin-triplet state with potential topological properties. Theoretically, spin-triplet superconductivity in UTe2 may be explained in terms of pairing mediated by either ferromagnetic or antiferromagnetic fluctuations. Experimentally, the magnetic properties of UTe2 remain enigmatic. Here we report muon spin rotation/relaxation (μSR) measurements on independently grown UTe2 single crystals that exhibit either a single or double phase transition in the specific heat near the onset of superconductivity. In the absence of an applied magnetic field, we observe an inhomogeneous distribution of magnetic fields in a sizeable volume fraction of all samples studied. The growth in the volume of the magnetic regions is halted by the onset of superconductivity at the critical temperature Tc. Upon further cooling, slow fluctuations of the local fields persist until a disordered spin frozen state appears below about one tenth of Tc. The μSR results are consistent with the formation of magnetic clusters in UTe2 due to the influence of disorder on long-range electronic correlations or geometrical magnetic frustration associated with the ladder-like U sublattice structure. Our findings suggest that inhomogeneous magnetic clusters are responsible for the ubiquitous residual linear term and low-temperature upturn in the temperature dependence of the specific heat in UTe2 below Tc. The omnipresent magnetic inhomogeneity has implications for the interpretation of other low-temperature experimental observations in the superconducting state of UTe2.
Conversations between earthquakes: Dynamics and delays of the 2019 Ridgecrest rupture sequence
Authors: Gabriel Alice-Agnes , Taufiqurrahman Taufiq , Li Duo , Ulrich Thomas , Li Bo , Carena Sara , Verdecchia Alessandro , Gallovič František 
Published: September 2022

Abstract
The overwhelming observational difficulties and the complexity of earthquake physics have rendered seismic hazard assessment largely empirical. Despite increasingly high-quality geodetic, seismic, and field observations, data-driven earthquake imaging yields stark differences and physics-based models explaining all observed dynamic complexities are elusive.
Here we present data-assimilated 3D dynamic rupture models which untwine California's biggest earthquakes in more than 20 years: the moment magnitude (Mw) 6.4 Searles Valley and Mw7.1 Ridgecrest, California, sequence breaking multiple segments of the same fault system. Our models use supercomputing to find the link between the two large earthquakes. We unify the uniquely high-quality strong-motion and teleseismic, field mapping, high-rate GNSS, and space geodetic foreshock and mainshock datasets with earthquake physics.
We find that the regional structure, the ambient long- and short-term stress, as well as the dynamic and static fault system interactions, are conjointly crucial to understand the dynamics and delays of the sequence. Dynamic rupture of a statically strong yet dynamically weak fault system is driven by overpressurized fluids and low dynamic friction in our models. The observed earthquake complexity results from static and dynamic stress changes acting across a non-vertical quasi-orthogonal conjugate fault structure.
We demonstrate that joint physics-based and data-driven illumination of the mechanics of complex fault systems and earthquake sequences is possible when reconciling dense earthquake recordings, 3D regional structure and stress models. We foresee that physics-based interpretation of big observational data-sets characterizing complex nonlinear systems will have a transformative impact on future geohazard mitigation.
Information and communication technology-based interventions for suicide prevention implemented in clinical settings: A scoping review
Authors: Shin Hwayeon Danielle , Durocher Keri , Sequeira Lydia , Zaheer Juveria , Torous John , Gillian Strudwick 
Published: September 2022

Abstract
Background
There is a surplus of information communication technology (ICT) based interventions for suicide prevention. However, little is known about which of these ICTs are implemented in clinical settings and their characteristics. This scoping review aimed to map and characterize evidence of ICTs for suicide prevention implemented in clinical settings. Furthermore, this review identified and characterized implementation barriers and facilitators, evaluation outcomes, and measures.
Methods
We conducted this review following the Joanna Briggs Institute methodology for scoping reviews. A search strategy was completed using the following databases between August 17–20, 2021: MEDLINE, Embase, CINAHL, PsycINFO, Web of Science, and Library, Information Science and Technology Abstracts. We also supplemented our search with Google searches and scanning of reference lists of relevant reviews. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews to report our findings.
Results
This review included a total of 75 articles, describing 70 studies and 66 ICTs for suicide prevention implemented in clinical settings. The majority of ICTs were computerized interventions and applications (n = 55). These ICTs were commonly used as indicated strategies (n = 49) targeting patients who were actively presenting with suicide risk. The three most common suicide prevention intervention categories identified were post-discharge follow-up (n = 27), screening and assessment (n = 22), and safety planning (n = 20). A paucity of reported information was identified related to implementation strategies, barriers and facilitators. The most reported implementation strategies included training, education, and collaborative initiatives. Barriers and facilitators of implementation included the need for resource supports, knowledge, skills, motivation as well as engagement with clinicians with research teams. Studies included outcomes at patient, clinician, and health system levels, and implementation outcomes included acceptability, feasibility, fidelity, and penetration.
Conclusion
The findings from this review illustrate several trends of the ICTs for suicide prevention in the literature and identify a need for future research to strengthen the evidence base for improving implementation. More effort is required to better understand and support the implementation and sustainability of ICTs in clinical settings. The findings can also serve as a future resource for researchers seeking to evaluate the impact and implementation of ICTs.