bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Place-Based Approach to Early Modern Women’s Writing
Authors: McQuade Paula 
Published: December 2022

Abstract
This chapter argues for the usefulness of local history to the study of early modern women writers. It suggests that local history offers a valuable way of thinking about the past, one which acknowledges the importance of the lives of otherwise unremarkable women and men. It explores the usefulness of local history for the study of early modern women’s writing, especially for the writings of women like Dorothy Burch, who may have possessed considerable power and authority within local communities but played no role in national, let alone international, events. By adopting a place-based approach, scholars of early modern women’s writing can emulate the heterodoxy and enthusiasm of female local historians. We can come to understand our work as participating within a tradition of women researchers who have also insisted upon the importance of the local, peripheral, and everyday.
‘The Surplusage’
Authors: Arthur Jake 
Published: December 2022

Abstract
This chapter examines the role of women in early modern literary traffic between Spain and England, particularly Margaret Tyler’s part in inaugurating a fashion for Spanish-origin chivalric romances in late sixteenth-century England. This history remains largely untold because we still overlook the literary opportunities that imitative modes of writing, like translation, afforded women. Translation is seen as self-effacement rather than a collaboration that requires or encourages literary agency. This chapter proposes an alternative approach to translation criticism that emphasises close comparative work between source and target text. It compares Tyler’s Mirrour of Princely Deedes and Knighthood with her Spanish source to demonstrate how even minor changes can have transformative effects. It contends that even as Tyler acculturates her text to her English audience and inaugurates a fashion for Spanish romances, she is prescient about changing English literary and cultural values that would make them objects of parody in the early seventeenth century.
An unexpected role for tomato threonine deaminase 2 in host defense against bacterial infection
Authors: Yeo In-Cheol , de Azevedo Manhaes Ana Marcia Escocard , Liu Jun , Avila Julian , He Ping , Devarenne Timothy P 
Published: December 2022

Abstract
The hormones salicylic acid (SA) and jasmonic acid (JA) often act antagonistically in controlling plant defense pathways in response to hemibiotrophs/biotrophs (hemi/biotroph) and herbivores/necrotrophs, respectively. Threonine deaminase (TD) converts threonine to α-ketobutyrate and ammonia as the committed step in isoleucine (Ile) biosynthesis and contributes to JA responses by producing the Ile needed to make the bioactive JA–Ile conjugate. Tomato (Solanum lycopersicum) plants have two TD genes: TD1 and TD2. A defensive role for TD2 against herbivores has been characterized in relation to JA–Ile production. However, it remains unknown whether TD2 is also involved in host defense against bacterial hemi/biotrophic and necrotrophic pathogens. Here, we show that in response to the bacterial pathogen-associated molecular pattern (PAMP) flagellin flg22 peptide, an activator of SA-based defense responses, TD2 activity is compromised, possibly through carboxy-terminal cleavage. TD2 knockdown (KD) plants showed increased resistance to the hemibiotrophic bacterial pathogen Pseudomonas syringae but were more susceptible to the necrotrophic fungal pathogen Botrytis cinerea, suggesting TD2 plays opposite roles in response to hemibiotrophic and necrotrophic pathogens. This TD2 KD plant differential response to different pathogens is consistent with SA- and JA-regulated defense gene expression. flg22-treated TD2 KD plants showed high expression levels of SA-responsive genes, whereas TD2 KD plants treated with the fungal PAMP chitin showed low expression levels of JA-responsive genes. This study indicates TD2 acts negatively in defense against hemibiotrophs and positively against necrotrophs and provides insight into a new TD2 function in the elaborate crosstalk between SA and JA signaling induced by pathogen infection.
Neurobiological mechanisms and related clinical treatment of addiction: a review
Authors: Fang Yehong , Sun Yunkai , Liu Yi , Liu Tieqiao , Hao Wei , Liao Yanhui 
Published: December 2022

AbstractDrug addiction or substance use disorder (SUD), has been conceptualized as a three-stage (i.e. binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation/craving) recurring cycle that involves complex changes in neuroplasticity, reward, motivation, desire, stress, memory, and cognitive control, and other related brain regions and brain circuits. Neuroimaging approaches, including magnetic resonance imaging, have been key to mapping neurobiological changes correlated to complex brain regions of SUD. In this review, we highlight the neurobiological mechanisms of these three stages of addiction. The abnormal activity of the ventral tegmental, nucleus accumbens, and caudate nucleus in the binge/intoxication stage involve the reward circuit of the midbrain limbic system. The changes in the orbitofrontal cortex, dorsolateral prefrontal cortex, amygdala, and hypothalamus emotional system in the withdrawal/negative affect stage involve increases in negative emotional states, dysphoric-like effects, and stress-like responses. The dysregulation of the insula and prefrontal lobes is associated with craving in the anticipation stage. Then, we review the present treatments of SUD based on these neuroimaging findings. Finally, we conclude that SUD is a chronically relapsing disorder with complex neurobiological mechanisms and multimodal stages, of which the craving stage with high relapse rate may be the key element in treatment efficacy of SUD. Precise interventions targeting different stages of SUD and characteristics of individuals might serve as a potential therapeutic strategy for SUD.
Structural covariance network of the hippocampus–amygdala complex in medication-naïve patients with first-episode major depressive disorder
Authors: Zhang Lianqing , Hu Xinyue , Hu Yongbo , Tang Mengyue , Qiu Hui , Zhu Ziyu , Gao Yingxue , Li Hailong , Kuang Weihong , Ji Weidong 
Published: December 2022

Abstract

Background
The hippocampus and amygdala are densely interconnected structures that work together in multiple affective and cognitive processes that are important to the etiology of major depressive disorder (MDD). Each of these structures consists of several heterogeneous subfields. We aim to explore the topologic properties of the volume-based intrinsic network within the hippocampus–amygdala complex in medication-naïve patients with first-episode MDD.

Methods
High-resolution T1-weighted magnetic resonance imaging scans were acquired from 123 first-episode, medication-naïve, and noncomorbid MDD patients and 81 age-, sex-, and education level-matched healthy control participants (HCs). The structural covariance network (SCN) was constructed for each group using the volumes of the hippocampal subfields and amygdala subregions; the weights of the edges were defined by the partial correlation coefficients between each pair of subfields/subregions, controlled for age, sex, education level, and intracranial volume. The global and nodal graph metrics were calculated and compared between groups.

Results
Compared with HCs, the SCN within the hippocampus–amygdala complex in patients with MDD showed a shortened mean characteristic path length, reduced modularity, and reduced small-worldness index. At the nodal level, the left hippocampal tail showed increased measures of centrality, segregation, and integration, while nodes in the left amygdala showed decreased measures of centrality, segregation, and integration in patients with MDD compared with HCs.

Conclusion
Our results provide the first evidence of atypical topologic characteristics within the hippocampus–amygdala complex in patients with MDD using structure network analysis. It provides more delineate mechanism of those two structures that underlying neuropathologic process in MDD.
Controversies in rheumatology: telemedicine—friend or foe?
Authors: Dejaco Christian , Landewé Robert B M 
Published: December 2022

Abstract
Telemedicine is increasingly used in rheumatology. While telemedicine guaranteed care of patients during the COVID-19 pandemic, it is now increasingly used to facilitate triage of patients, monitoring of disease activity, and patients’ education. In addition, tele-visits as well as remote physio- and psychotherapy are replacing traditional face-to-face contacts between patients and their healthcare provider. While this may save resources in a world in which the gap between the demand and the provision of healthcare increases, there is also a danger of losing essential information, for example by non-verbal communication, that can only be retrieved during face-to-face contact in the office. In addition, it may be challenging to build a trusting relationship between patients and healthcare professionals by virtual means only. Globally acting companies that see market opportunities already amply offer ‘simple’ technical solutions for telemedicine. While such solutions may seem (economically) interesting at first glance, there is a risk of monopolization, leaving the most valuable parts of healthcare to a small number of profit-seeking companies. In this article, the opportunities and threats of telemedicine in rheumatology are debated. A possible way forward is to complement traditional face-to-face visits with information gained by telemedicine, in order to render these consultations more efficient rather than replacing personal contact by technology.
Need for Treatment, A Less Restrictive Alternative to Hospitalization, and Treatment Provision: The Utility of Community Treatment Orders
Authors: Segal Steven P , Rimes Lachlan , Badran Leena 
Published: December 2022

Abstract

Background
Provision of involuntary care is an abridgment of civil rights and a source of controversy. Its circumstances require continued monitoring. This study asks 4 questions: Whether, in an era, focused on allowing patients with capacity to refuse community-treatment-order (CTO)-assignments, CTO use decreased. And whether CTOs fulfilled 3 statute mandates: Were CTO-assigned patients in greater need of treatment than other psychiatric inpatients? Was CTO assignment a less-restrictive alternative to psychiatric hospitalization? and Did CTO assignment provide needed treatment at internationally recommended levels with consequences for patient outcomes?

Method
All 214 388 Victoria, Australia mental health admissions between 2000– 2017 were reviewed. Two cohort samples were drawn and followed through 2019—ie, all 7826 hospitalized patients who were first placed on CTOs from 2010 to 2017 and 13 896 hospitalized patients without CTO placement. Logistic Regression was used to specify determinants of CTO assignment from the psychiatric inpatient population. OLS Regression with propensity score control to evaluate study questions.

Results
In the 2010–2017 decade, initial CTO assignments decreased by 3.5%, and initial hospitalizations increased by 5.9% compared to the 2000–2009 period. At hospital admission and discharge, based on Health of the Nations Score ratings, the CTO-cohort’s need for treatment exceeded that of non-CTO patients. CTO patients had 3.75 fewer days in average inpatient episode duration than other inpatients, when adjusted for CTO-assignment determinants, the ratio of patients to community case managers, and patient housing status. CTO patients needing rehospitalization spent 112.68 more days in the community than re-hospitalized non-CTO patients. Patient to case-manager ratios falling above recommended levels and the patient marginal housing status contributed to longer hospital stays and reduced community tenure.

Conclusions
Victoria relied less on CTOs as an LRA, consequently, experiencing increased initial hospitalizations. CTO patients were in greater need of treatment than non-CTO patients, yet, with required oversite had shorter hospitalizations and more time out of hospital prior to rehospitalization than the less severely ill non-CTO group. Patient LRA outcomes were adversely affected by higher than recommended community patient to case-manager ratios limiting needed treatment provision to hospital.
Assessing sleep health dimensions in frontline registered nurses during the COVID-19 pandemic: implications for psychological health and wellbeing
Authors: Norful Allison A , Haghighi Fatemeh , Shechter Ari 
Published: December 2022

AbstractThe COVID-19 pandemic altered work environments of nurses, yielding high rates of stress and burnout. Potential protective factors, including effective sleep, may influence psychological health and wellbeing. Evidence about sleep in nurses may help develop interventions that mitigate burnout and poor psychological outcomes. A cross sectional survey was distributed across three hospitals to nurses in New York City (NYC). During the first wave of the pandemic (March–April 2020), NYC had the highest incidence of laboratory-confirmed COVID-19 cases (915/100 000) and half of all COVID-related deaths nationwide. Multivariable logistic regression was used to determine associations between Pittsburgh Sleep Quality Index (PSQI) global sleep score, PSQI sleep dimensions, and psychological health (burnout, depression, anxiety, and compassion fatigue), unadjusted and then controlling for individual and professional characteristics. More than half of the participants reported burnout (64%), depression, (67%), and anxiety (77%). Eighty percent of participants had PSQI global scores &gt;5 (poor sleep) (mean 9.27, SD 4.14). Respondents reporting good sleep (PSQI ≤ 5) had over five times the odds of no burnout (OR: 5.65, 95% CI: 2.60, 12.27); increased odds of screening negative for depression (OR: 6.91, 95% CI: 3.24, 14.72), anxiety (OR: 10.75, 95% CI: 4.22, 27.42), and compassion fatigue (OR: 7.88, 95% CI: 1.97, 31.51). Poor subjective sleep quality PSQI subcomponent was associated with burnout (OR: 2.21, 95% CI: 1.41, 3.48) but sleep duration subcomponent was not (OR: 0.84, 95% CI: 0.59, 1.19). Daytime dysfunction was significantly associated with all psychological outcomes. Sleep disturbances and medications yielded higher anxiety odds. Overall, sleep quality appears more strongly related to burnout than sleep duration in nurses working during the COVID-19 pandemic. Sleep interventions should target individual sleep dimensions in nurses.
Pain Widespreadedness, and Not Primary Pain Location, is Associated With Comorbid Symptoms in Children With Chronic Pain
Authors: Foxen-Craft Emily , Bourchtein Elizaveta , Kaplan Chelsea , Clauw Daniel J. , Scott Eric 
Published: December 2022

Objectives:
Pediatric chronic pain represents heterogeneous diagnoses; often, primary pain location informs research classifications and treatment. In contrast, recent research has highlighted the role of widespread pain and this perspective has been adopted in assessments in specialty pediatric pain clinics. The lack of direct comparison between these 2 methods of categorizing pediatric chronic pain may hinder the adoption of evidence-based practices across the spectrum of care. Therefore, this study aimed to compare whether primary pain location or pain widespreadedness is more informative for pain-related symptoms in pediatric chronic pain.

Methods:
Youth (n=223) between the ages of 8 to 23 years (M=15.93, SD=2.11, 83% female) completed surveys upon intake at the pediatric chronic pain clinic. Free-text entries of primary pain location were coded into categories: headache, abdominal pain, and musculoskeletal pain. Additional domains assessed included widespread pain, pain interference, kinesiophobia, catastrophizing, anxiety, depression, sleep, and fatigue.

Results:
Differences based on primary pain location only emerged for kinesiophobia, F(2150)=8.20, P<0.001, with the highest scores among those with musculoskeletal pain. In contrast, controlling for sex, age, and pain intensity, pain widespreadedness was associated with pain interference, pain catastrophizing, fatigue, anxiety, and depression (P<0.05).

Discussion:
Pain widespreadedness was more consistently associated with pain-related outcomes among pediatric chronic pain patients than primary pain location, and body maps may be useful in determining a nociplastic pain mechanism to inform treatment. Improved assessment of pediatric pain mechanisms may help advance more precise treatment delivery.
Are Improvements in Pain Neurophysiology Knowledge Following Pain Science Education Associated With Improved Outcomes in People With Chronic Pain?
Authors: Ram Adrian , Booth John , Thom Jeanette M. , Gibbs Mitchell T. , Jones Matthew D. 
Published: December 2022

Objective:
This systematic review and meta-analysis aimed to determine the association between changes in patients’ pain knowledge after pain science education (PSE) with treatment outcomes in people with chronic pain.

Methods:
Six electronic databases and 2 clinical trial registries were searched from inception to September 15, 2021 for studies where participants received PSE and had their pain knowledge and clinical outcomes assessed before and after PSE. Meta-analyses were performed for pain intensity, kinesiophobia, and pain catastrophizing. Physical function and quality of life outcomes were synthesized narratively. Risk of bias was assessed using the Cochrane tool for nonrandomized studies and the quality of evidence was assessed using GRADE.

Results:
Fourteen studies (n=1500 participants) were included. Meta-analyses revealed no significant associations between short-term (<12 wk) changes in pain neurophysiology knowledge with changes in pain intensity (n=1075, r=−0.01, 95% CI =−0.14 to 0.13, very low certainty), kinesiophobia (n=152, r=0.02, 95% CI =−0.27 to 0.24, very low certainty) and pain catastrophizing (n=976, r=−0.03, 95% CI=−0.18 to 0.11, low certainty). No significant associations were found between short-term changes in pain neurophysiology knowledge and physical function or quality of life either.

Discussion:
These findings do not support a short-term association between improvements in pain neurophysiology knowledge and better treatment outcomes in people with chronic pain. Increased understanding of how PSE works, as well as better ways to measure it, may help clinicians deliver more targeted education to help patients reconceptualize pain and promote engagement in active treatment strategies (eg, exercise).
The Impacts of Lymph on the Adipogenesis of Adipose-Derived Stem Cells
Authors: Hsiao Hui-Yi , Liu Jia-Wei , Pappalardo Marco , Cheng Ming-Huei 
Published: December 2022

Background:
The pathophysiology of adipose proliferation or differentiation in extremity lymphedema has not been thoroughly studied. This study investigated the impacts of the lymph harvested from lymphedematous limbs on the adipogenesis of adipose-derived stem cells (ASCs).

Methods:
ASCs were isolated from the adipose tissue of normal extremities and cultured with lymph collected from Cheng’s Lymphedema Grade III-IV patients or adipogenic differentiation medium (ADM) and further subjected to differentiation and proliferation assay. The expression of adipogenesis genes was examined by RT-PCR to investigate the effect of lymph on ASCs. The level of adipogenic cytokines in the lymph was also evaluated.

Results:
The size of the adipocytes were significantly larger in lymphedema fat tissue compared to that in normal fat tissues (p < 0.00). The adipogenesis of ASCs cultured in lymph was significantly enhanced than in ADM (p= 0.008) on Day 10, suggesting the adipogenesis of ASCs was promoted under the lymph-cultured environment. The expression of adipogenesis genes, PPARγ (p= 0.02), C/EBPα (p= 0.008); FABP4: (p= 0.004), LPL (p=0.003), were statistically elevated when the ASCs were cultured with lymph. The insulin content in lymph was statistically higher in the lymph (p < 0.001) than that in plasma.

Conclusions:
The adipogenesis of ASCs was promoted under the lymph-cultured environment with statistically increased adipogenesis genes of PPARγ, C/EBPα, FABP4, and LPL. The excess lymph accumulated in the lymphedematous extremity contained a greater insulin/IGF-2. These adipogenic factors promoted the expression of early adipogenesis genes and led ASCs to undergo adipogenesis and differentiated into adipocytes.

Clinical Relevance Statement
The accumulation of adipose tissue in lymphedema region was contributed from the content of excess lymph.
Management of Dog Bite Injuries
Authors: Means Olivia , Fernstrum Colton , Lucich Elizabeth , Little Andrea , Dietze-Fiedler Megan , Pumarada-Fernandez Deborah , Swamy Viswanath , Girotto John 
Published: December 2022

BackgroundDog bite injuries are common within the pediatric population. Currently, there are inconclusive data on best sedation practice, antibiotic regimen, and need for plastic surgery referrals for treatment of dog bite injuries in the emergency department (ED) versus operating room (OR). This study set out to determine sedation practice, infection management, and necessity for plastic surgery referral at a level I pediatric trauma center.MethodsA retrospective review of all pediatric (0–18 years old) dog bites documented in electronic medical records from January 1, 2010, to December 31, 2019, was performed.Bitten by dogencounters were identified byInternational Classification of Diseases, Ninth RevisionandTenth Revisioncodes E906.0 and W54.0, W54.0XXA, and W54, respectively. Data gathered included age, gender, month of injury, circumstance of injury, injury characteristics, location of repair, person performing repair, sedation (if used, then length of sedation), inpatient admission, antibiotics prescribed, dog characteristics (breed, size, sex, age, relationship to patient), and complications. Summary statistics were calculated as mean ± SD. Comparisons for nominal variables were performed using theχ2test. All analyses were performed using Stata v.16. 1.ResultsA total of 1438 pediatric patients were included in this study over a 10-year period. Of injuries requiring repair (n = 846), most repairs were performed in the ED (97.1% [822/846]), whereas 24 (2.8%) required repair in the OR. Of the bites that required repair (n = 846), 81.1% (686/846) were performed by an emergency medicine physician and 147 (17.4%) by plastic surgeons. Procedural sedation in the ED was performed in 146 repairs (17.3%). Documented sedation time ranged from 10 to 96 minutes. Most patients received a prescription for antibiotics (80.5%), usually amoxicillin/clavulanate (90.8%). Infection was the most common sequela (9.5%). There was no significant difference in infection rates between repairs performed in the ED versus those in the OR.ConclusionOur study indicates that pediatric patient dog bite injuries can be successfully managed in an ED. Procedural sedation has demonstrated no increased safety risks compared with the OR. Rates of infection are also not demonstrated to be significantly higher in repairs done in the ED versus those taken to operating theater.