bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of Carbamazepine-Induced Toxic Epidermal Necrolysis With Clinical Gastrointestinal Involvement: A Case Report
Authors: Chi Le Quynh , Anh Nguyen Thi Van , Le Nguyen Ngoc Quynh , Ha Nguyen Thi Thu , Tien Hoang Minh , Dien Tran Minh 
Published: April 2022

BackgroundStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare and life-threatening disease of the skin and mucosal surfaces. Although gastrointestinal manifestations in adults are potential prognostic factors for disease severity, there are limited data on such cases and their standard management in the pediatric population.Case PresentationWe herein report the case of an 8-year-old girl with a 1-year history of epilepsy, who presented with bilateral conjunctivitis and progressively widespread bullous, and pruritic eruption based on erythematous skin after administration of carbamazepine. A diagnosis of carbamazepine-induced TEN was made, and the drug was immediately discontinued. The result of genetic screening showed that the patient was positive for the HLA-B*15:02 allele. Then, her condition got worse by developing gastrointestinal involvement, including hematemesis and severe watery bloody diarrhea. A combination of the intravenous immunoglobulin and the appropriate dose of systemic steroids have contributed to a favorable outcome in this case. Multidisciplinary care of mucocutaneous involvement, supplemental nutrition, and fluid replacement was also critically warranted. This report aims to contribute to the current literature on TEN-related gastrointestinal manifestations in pediatrics and highlights the need for further investigations in determining the optimal treatment in such cases.ConclusionIn conclusion, we reported the successful treatment of TEN-related gastrointestinal manifestations in a pediatric patient, which should be critically considered in patients with SJS/TEN. Since it may significantly contribute to the poor prognosis of the illness, further investigations in determining standard management in such cases are necessary.
Limited Open Reduction and Transepiphyseal Intramedullary Kirschner Wire Fixation for Treatment of Irreducible Distal Radius Diaphyseal Metaphyseal Junction Fracture in Older Children
Authors: Wang Rufa , Wu Liwei , Wang Yinming , Fan Minjie , Wang Yiwei , Ning Bo , Zheng Pengfei 
Published: April 2022

ObjectiveThis study aimed to compare limited open reduction and transepiphyseal intramedullary fixation with Kirschner wire (LOR-TIKW) versus open reduction and internal fixation with plate and screw (ORIF-PS) for treatment of irreducible distal radius diaphyseal–metaphyseal junction (DMJ) fracture in older children.MethodsData of children (aged 10–14 years) treated in our hospital for distal radius DMJ fractures with LOR-TIKW or ORIF-PS from January 2018 to December 2019 were retrospectively analyzed. Follow-up was until radiographic union. Demographic, clinical, and radiographic data; treatment cost; healing time; functional outcome (by Price criteria); complications; and postoperative angulation and displacement were compared between children treated by the two methods. Statistical analysis was performed with alpha set at P &lt; 0.05.ResultsA total of 26 children were included: 14 treated with LOR-TIKW and 12 with ORIF-PS. Operation time was less (22.1 min vs. 46.7 min, P &lt; 0.0001), surgical incision smaller (2.43 cm vs. 5.00 cm, P &lt; 0.0001), cost of internal fixation lower (US$, 40.6 vs. 2020, P &lt; 0.0001), and healing time shorter (4.79 weeks vs. 5.64 weeks, P = 0.03) with LOR-TIKW; however, postoperative fracture angulation was slightly larger (1.07° vs. 0.83°, P = 0.85) and displacement slightly more (0.86 mm vs. 0.58 mm, P = 0.44) in the LOR-TIKW group. Rate of union, functional outcome, and complications were not significantly different between the groups.ConclusionFor irreducible DMJ fracture of distal radius in older children, LOR-TIKW appears to be a promising method with several advantages over ORIF-PS.
Prediction of the Effects of Liraglutide on Kidney and Cardiovascular Outcomes Based on Short-Term Changes in Multiple Risk Markers
Authors: Tye Sok Cin , de Vries Sieta T. , Mann Johannes F. E. , Schechter Meir , Mosenzon Ofri , Denig Petra , Heerspink Hiddo J. L. 
Published: April 2022

Aims: The LEADER trial demonstrated that the glucagon-like peptide-1 receptor agonist (GLP1-RA) liraglutide reduces kidney and cardiovascular (CV) risk in patients with type 2 diabetes. We previously developed a Parameter Response Efficacy (PRE) score that translates multiple short-term risk marker changes, from baseline to first available follow-up measurement, into a predicted long-term drug effect on clinical outcomes. The objective of this study was to assess the accuracy of the PRE score in predicting the efficacy of liraglutide in reducing the risk of kidney and CV outcomes.Methods: Short-term changes in glycated hemoglobin (HbA1c), systolic blood pressure (BP), urinary-albumin-creatinine-ratio (UACR), hemoglobin, body weight, high-density-lipoprotein (HDL) cholesterol, low-density-lipoprotein (LDL) cholesterol, and potassium were monitored in the LEADER trial. Associations between risk markers and kidney or CV outcomes were established using a multivariable Cox proportional hazards model in a separate pooled database of 6,355 patients with type 2 diabetes. The regression coefficients were then applied to the short-term risk markers in the LEADER trial to predict the effects of liraglutide on kidney (defined as a composite of doubling of serum creatinine or end-stage kidney disease) and CV (defined as a composite of non-fatal myocardial infarction, non-fatal stroke, and CV death) outcomes.Results: Liraglutide compared to placebo reduced HbA1c (1.4%), systolic BP (3.0 mmHg), UACR (13.2%), body weight (2.3 kg), hemoglobin (2.6 g/L), and increased HDL-cholesterol (0.01 mmol/L) (all p-values &lt;0.01). Integrating multiple risk marker changes in the PRE score resulted in a predicted relative risk reduction (RRR) of 16.2% (95% CI 13.7–18.6) on kidney outcomes which was close to the observed RRR of 15.5% (95% CI -9.0–34.6). For the CV outcome, the PRE score predicted a 7.6% (95% CI 6.8–8.3) RRR, which was less than the observed 13.2% (95% CI 3.2–22.2) RRR.Conclusion: Integrating multiple short-term risk markers using the PRE score adequately predicted the effect of liraglutide on the composite kidney outcome. However, the PRE score underestimated the effect of liraglutide for the composite CV outcome, suggesting that the risk markers included in the PRE score do not fully capture the CV benefit of liraglutide.
Metformin and Thymoquinone Synergistically Inhibit Proliferation of Imatinib-Resistant Human Leukemic Cells
Authors: Glamoclija Una , Mahmutovic Lejla , Bilajac Esma , Soljic Violeta , Vukojevic Katarina , Suljagic Mirza 
Published: April 2022

Chemotherapy resistance is one of the major challenges in cancer treatment, including leukemia. A massive array of research is evaluating combinations of drugs directed against different intracellular signaling molecules to overcome cancer resistance, increase therapy effectiveness, and decrease its adverse effects. Combining chemicals with proven safety profiles, such as drugs already used in therapy and active substances isolated from natural sources, could potentially have superior effects compared to monotherapies. In this study, we evaluated the effects of metformin and thymoquinone (TQ) as monotherapy and combinatorial treatments in chronic myeloid leukemia (CML) cell lines sensitive and resistant to imatinib therapy. The effects were also evaluated in primary monocytic acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) cells. Both compounds induced a dose- and time-dependent decrease of viability and proliferation in tested cells. Metformin had similar IC50 values in imatinib-sensitive and imatinib-resistant cell lines. IC50 values of TQ were significantly higher in imatinib-resistant cells, but with a limited resistance index (2.4). Synergistic effects of combinatorial treatments were observed in all tested cell lines, as well as in primary cells. The strongest synergistic effects were observed in the inhibition of imatinib-resistant cell line proliferation. Metformin and TQ inhibited the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and induced apoptosis in tested cell lines and primary cells. The enhanced effects of combinatorial treatments on the induction of apoptosis were more dominant in imatinib-resistant compared to imatinib-sensitive CML cells. Primary cells were more sensitive to combinatorial treatments compared to cell lines. A combination of 1.25 mM metformin and 0.625 µM TQ increased the levels of cleaved poly (ADP-ribose) polymerase (PARP), decreased the levels of proliferation regulatory proteins, and inhibited protein kinase B (Akt) and NF-κB signaling in primary CLL cells. This study demonstrates that combinatorial treatments of imatinib-resistant malignant clones with metformin and TQ by complementary intracellular multi-targeting represents a promising approach in future studies.
Multiple Resonances Induced Terahertz Broadband Filtering in a Bilayer Metamaterial
Authors: Zeng Qiuming , Huang Yi , Zhong Shuncong , Lin Tingling , Zhong Yujie , Zhang Zhenghao , Yu Yingjie , Peng Zhike 
Published: April 2022

A bilayer metamaterial to realize the broadband transmission in a terahertz (THz) filter was proposed, whose periodic unit structure consists of two rectangular apertures. The broadband consisting of three transmission peaks has a 3dB transmission range of 0.75 THz, which is 1.6 times that of the monolayer structure. Different from the traditional narrow band excitation mode, two additional transmission peaks are produced by the bilayer metamaterials. Sweeping frequency analysis has illustrated that the spacing between two layers of metamaterials has an influence on these additional transmission peaks. The bandwidth ranges can be regulated by adjusting the spacing at a proportional height. In particular, the experimental results show that the proposed filter has an excellent frequency selective performance with a bandwidth of 0.7 THz from 0.79 THz to 1.49 THz. This design of broadband filtering by introducing the bilayer metamaterial supplies a new approach with potential application in the THz broadband filter.
The Research of Long-Optical-Path Visible Laser Polarization Characteristics in Smoke Environment
Authors: Juntong Zhan , Shicheng Bao , Su Zhang , Qiang Fu , Yingchao Li , Jin Duan , Wei Zhang 
Published: April 2022

The concentration of smoke in an environment can cause obvious interference to visible light intensity imaging, and it is a non-negligible factor in the polarized imaging of ground-based targets. Smoke particles cause severe scattering of photon intensity, resulting in polarization. In this case, low-visibility targets can be effectively identified by detecting the polarization dimension of targets. However, the polarization transmission of smoke in an environment is unclear, and the theoretical simulation lacks experimental reliability verification. To study this problem, this study constructs a polarization transmission model in a smoke environment and simulates and analyzes the scattering of visible polarized light at 450, 532, and 671 nm under different smoke densities. The optical thickness is determined to establish a reliable connection between the simulation and the external field long optical path test and verify the transmission of polarized light. Results show that the method has a 60% confidence in the polarization transmission model. With the increase in optical thickness, the degree of polarization (DOP) of the three wavelengths in the visible light band decreases, and the DOP of each polarized light decreases. No obvious difference is found between the DOPs of circularly polarized light at 450 nm and linearly polarized light. The DOP of circularly polarized light at 532 nm is 1–5% higher than that of linearly polarized light, 1–10% higher than that of the outdoor test, 1–5% higher than that of circularly polarized light at 671 nm, and 2–15% higher than that of the outdoor test. Therefore, the shorter the wavelength in the visible band, the higher the DOP. With the increase in wavelength, the polarization characteristics of circularly polarized light are gradually better than those of linearly polarized light.
The Relationship Among Body Composition and Anaerobic Capacity and the Sport Level of Elite Male Motorcycle Speedway Riders
Authors: Michalik Kamil , Szczepan Stefan , Markowski Maciej , Zatoń Marek 
Published: April 2022

The main objective of this study was to investigate the relationship among anaerobic capacity, body composition, and sport level of male junior and senior speedway riders. Sixty riders of professional clubs in the Polish top motorcycle speedway league participated in this study. They were divided into two equal groups (n = 30): junior (age = 19.7 ± 1.1 years) and senior (age = 29.7 ± 5.2). Body composition assessment, Wingate test (WAnT) on cycloergometer, with analysis of acute cardiorespiratory and biochemical responses were performed. Sport level was defined as the number of heats (races) won, winning percentage, total points scored during the season, and average points scored per heat. Seniors had higher point ratings indicating sport levels. As compared to the seniors, the juniors had lower BMI 4% (p &lt; 0.01) and fat tissue mass by 20.5% (p &lt; 0.01). A higher power decrease of 2.3% (p &lt; 0.05) in the WAnT test was found in seniors. Body height negatively correlated with all indicators of seniors’ sport level (r = −0.41 to −0.55). Peak power output negatively correlated with seniors’ sport level (r = −0.39 to −0.41). Among the seniors, there was a negative correlation between post-exercise hydrogen ion concentration (r = −0.38), carbon dioxide partial pressure (r = −0.45) and average points scored per season. Conclusion: The anthropometric characteristics of body height, lean body mass and body surface area, are significantly correlated with the sport levels of the seniors motorcycle speedway riders. When selecting motorcycle speedway riders, use of these anthropometric characteristics may aid in determining the riders with the most potential to be successful. Metabolic acidosis tolerance and gas exchange efficiency show significance in seniors, indicating the need for intense exercise sessions.
Gambling, Gaming, and Internet Behavior in a Sexual Minority Perspective. A Cross-Sectional Study in Seven European Countries
Authors: Broman Niroshani , Prever Fulvia , di Giacomo Ester , Jiménez-Murcia Susana , Szczegielniak Anna , Hansson Helena , Håkansson Anders 
Published: April 2022

BackgroundAddictive behavior of gambling, gaming and internet activity is partly a new research domain and has not been well investigated with regard to sexual minority populations. Although health disparities between sexual minorities and the general population are well documented, there is a lack of inclusion of sexual minorities in both research and clinic. Among lesbian, gay and bisexual populations certain features could be present that play a role for the development of addictive behaviors, such as social isolation and increased risk of other psychiatric problems. The aim of this study was to investigate problem gambling, problem gaming and problematic internet behavior in a European context and if it is affected by sexual orientation status.MethodsAn online web-survey was distributed among web-panels in England, Poland, Switzerland, Italy, Spain, Denmark, and Sweden in 2017–2018.Result10 983 complete answers were collected. 7.1% of the participants had a sexual minority status (n = 774). Regression models found that there was no difference in gambling, gaming and internet behavior among heterosexual and sexual minority men. Sexual minority women were associated with problematic gambling and gaming behavior, when also controlling for age and nationality. When also controlling for psychological distress, women defining as having another sexual minority status than lesbian and bisexual remained significant for having a problematic gaming behavior (AOR = 2.3).ConclusionAn awareness of female sexual minority perspectives is relevant in facilities treating behavioral addiction as well as in future research in behavioral addiction. More research is needed in problematic gambling and gaming behavior in different sexual minority populations with regard to psychiatric comorbidity and living conditions. An inclusion of sexual minority groups defining as other than gay and bisexual is needed in future research. No significant differences were found between heterosexual and sexual minority men in adjusted analysis in this study.
Job Burnout Is Associated With Prehospital Decision Delay: An Internet-Based Survey in China
Authors: Yin Han , Jiang Cheng , Shi Xiaohe , Chen Yilin , Yu Xueju , Wang Yu , Li Weiya , Ma Huan , Geng Qingshan 
Published: April 2022

BackgroundPrehospital delay is associated with non-modifiable factors such as age, residential region, and disease severity. However, the impact of psychosocial factors especially for job burnout on prehospital decision delay is still little understood.MethodThis internet-based survey was conducted between 14 February 2021 and 5 March 2021 in China through the Wechat platform and web page. Self-designed questionnaires about the expected and actual length of prehospital decision time and the Chinese version of Maslach Burnout Inventory-General Survey, Type D Personality Scale-14, and Social Support Rating Scale were applied. A total of 1,039 general participants with a history of perceptible but tolerable body discomfort were included.ResultsThe top six reasons for prehospital decision delay were: (1) endure until self-healing (50.7%), (2) too busy to ask for leave (40.3%), (3) process for seeing a doctor too complicated (35.8%), (4) too tired after work (26.2%), (5) worry about the expenditure (16.6%), and (6) fear of being identified as with serious problem (14.5%). The univariate analyses revealed that older age (p = 0.001), type D personality (p = 0.025), job burnout (p = 0.055), and worrying about expenditure (p = 0.004) were associated with prolonged prehospital decision time, while engaged in medical-related job (p = 0.028) and with more social support (p = 0.066) would shorten the delay. The multivariate analysis using logistic regression model with forward selecting method showed that age [per 10 years, odds ratio (OR) 1.19 (1.09–1.31), p &lt; 0.001], job burnout [per 10 points in Maslach Burnout Inventory-General Survey (MBI-GS), OR 1.17 (1.04–1.31), p = 0.007], and worrying about expenditure [OR 1.75 (1.25–2.47), p = 0.001] were the three determinants for prehospital decision delay (&gt;7 days). Mediating effects were analyzed by using bias-corrected percentile bootstrap methods (N = 10,000). Social support was found partially mediated the relationship between the determinants and prehospital decision time. The partial mediating effect of social support accounted for 24.0% of the total effect for job burnout and 11.6% for worrying about expenditure.ConclusionPsychosocial factors have a non-negligible impact on prehospital decision delay. The crucial part of prehospital decision delay may be the lack of motivation inside. Job burnout and lack of social support, as two commonly seen features in the modern world, should be given enough consideration in disease prevention and treatment.
No Significant Changes in Addictive and Problematic Behaviors During the COVID-19 Pandemic and Related Lockdowns: A Three-Wave Longitudinal Study
Authors: Koós Mónika , Demetrovics Zsolt , Griffiths Mark D. , Bőthe Beáta 
Published: April 2022

IntroductionThe COVID-19 outbreak and related lockdowns brought substantial changes in people’s lives and led to concerns about possible increases of addictive behaviors at the initial stages of the pandemic. To examine these concerns, the aim of the present study was to assess longitudinal changes in addictive and problematic behaviors (i.e., problematic social media use, Internet gaming disorder, gambling disorder, problematic pornography use, and compulsive sexual behavior disorder) over time during the COVID-19 pandemic.MethodsThree waves of data collection took place in different stages of the COVID-19 outbreak in Hungary in a general population, from the first wave of lockdowns to the second and third waves of restrictions (May, 2020; NT1 = 1747; June–August, 2020; NT2 = 656; January, 2021; NT3 = 411). Latent growth curve models were calculated to assess the potential changes in addictive and problematic behaviors over time.ResultsLatent growth curve models showed that the sample varied in their initial scores, but there were no significant changes over time in any of the examined behaviors, except for compulsive sexual behavior disorder, which demonstrated a small but significant increase (i.e., positive and significant slope factor). However, the rate of this change was negligible. Overall, there were no noteworthy changes over time regarding any of the examined addictive and problematic behaviors.ConclusionContrary to initial concerns, no substantial changes over time were observed regarding the examined addictive behaviors during the COVID-19 pandemic and related lockdowns. These findings indicate that those who had no previous problem with these addictive behaviors, might have not developed a problem, and those who had problem with either of the behaviors previously, might have not experienced a significant increase in their symptoms.
The Global 2000-2020 Land Cover and Land Use Change Dataset Derived From the Landsat Archive: First Results
Authors: Potapov Peter , Hansen Matthew C. , Pickens Amy , Hernandez-Serna Andres , Tyukavina Alexandra , Turubanova Svetlana , Zalles Viviana , Li Xinyuan , Khan Ahmad , Stolle Fred , Harris Nancy , Song Xiao-Peng , Baggett Antoine , Kommareddy Indrani , Kommareddy Anil 
Published: April 2022

Recent advances in Landsat archive data processing and characterization enhanced our capacity to map land cover and land use globally with higher precision, temporal frequency, and thematic detail. Here, we present the first results from a project aimed at annual multidecadal land monitoring providing critical information for tracking global progress towards sustainable development. The global 30-m spatial resolution dataset quantifies changes in forest extent and height, cropland, built-up lands, surface water, and perennial snow and ice extent from the year 2000 to 2020. Landsat Analysis Ready Data served as an input for land cover and use mapping. Each thematic product was independently derived using locally and regionally calibrated machine learning tools. Thematic maps validation using a statistical sample of reference data confirmed their high accuracy (user’s and producer’s accuracies above 85% for all land cover and land use themes, except for built-up lands). Our results revealed dramatic changes in global land cover and land use over the past 20 years. The bitemporal dataset is publicly available and serves as a first input for the global land monitoring system.