bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Kejadian Tromboembolisme Vaskular Terhadap Mortalitas COVID-19: Sebuah Studi Literatur
Authors: Anwar Raihanah , Huspa Fitri Agustina , Bisri Yulianti 
Published: March 2022

Latar Belakang: COVID-19, infeksi virus akibat SARS-CoV-2, menampilkan berbagai gambaran klinis dari gejala asimtomatik hingga kematian. Respons inflamasi pada COVID-19 menyebabkan fase hiperkoagulasi dan mengakibatkan lebih dari 25% kejadian tromboembolisme pada pasien rawat inap COVID-19. Pada tromboembolisme, terjadi elevasi level D-dimer, hal ini berasosiasi dengan perburukan prognosis dan mortalitas pasien COVID-19. Penelitian ini bertujuan untuk mengevaluasi penelitian yang menganalisis hubungan kejadian tromboembolisme pada COVID-19 dan mortalitas. Diharapkan, penelitian ini dapat menjadi dasar bagi para klinisi untuk mengevaluasi penatalaksanaan COVID-19.
Metode: Penelitian menggunakan pendekatan studi literatur dengan kata kunci “Thromboembolism” atau “Venous Thromboembolism”, “COVID-19”, “SARS-CoV-2” atau “Coronavirus Disease 2019”, dan “Mortality” melalui database PubMed dan disaring berdasarkan kriteria yang telah ditetapkan.
Hasil: Dari 4 artikel yang sesuai dengan kriteria inklusi, dua artikel menyatakan adanya hubungan kejadian tromboembolisme dengan kematian pada pasien COVID-19 dan dua artikel menyatakan tidak ada hubungan. Untuk mengklarifikasi dua pernyataan yang kontradiktif tersebut, peneliti mencari lebih dalam penelitian yang mendukung.
Simpulan: Keempat artikel yang dianalisis melaporkan tingginya kejadian tromboembolisme pada pasien COVID-19. Dua di antaranya menyatakan asosiasi antara tromboembolisme dan kematian pada COVID-19 dan sisanya menyatakan tidak ada asosisasi. Namun, pertanyaan penelitian untuk mengetahui hubungan kejadian tromboembolisme pada COVID-19 dengan kematian masih belum dapat diketahui.
Anestetik Lokal dan Prosedur Endoskopi Saluran Cerna
Authors: Tantri Aida Rosita 
Published: March 2022

Prosedur endoskopi saluran cerna adalah prosedur yang saat ini sudah rutin dikerjakan dengan menggunakan sedatif dan analgesik intravena. Tujuan penggunaan kedua zat tersebut selama prosedur endoskopi adalah untuk mengurangi kecemasan dan ketidaknyamanan pasien, meningkatkan kualitas dari hasil endoskopi, dan mengurangi ingatan pasien terhadap tindakan endoskopi.1 Tindakan endoskopi umumnya dilaksanakan dengan sedasi sedang, yang dapat dicapai dengan pemberian agen sedasi secara titrasi agar tindakan endoskopi dapat berjalan lancar dan aman bagi pasien.2
Walau sudah mencapai level sedasi sedang, gag reflex masih seringkali terjadi pada pasien. Untuk mengatasi hal tersebut, ahli anestesi dapat menambahkan fentanyl atau remifentanyl. Penambahan opioid juga dapat diberikan, namun perlu berhati-hati karena dapat mengakibatkan depresi napas dan pergeseran level sedasi. Pasien dapat jatuh pada level sedasi yang lebih dalam sehingga membutuhkan bantuan jalan napas, respirasi atau bahkan kardiovaskular.3
Kebutuhan metode dalam mengurangi nyeri dan gag reflex selama tindakan endoskopi sangat diperlukan. Penggunaan anestetik lokal yang benar dan efektif dapat mengurangi dosis sedasi dan komplikasi yang ditimbulkan. Salah satu jenis anestetik lokal yang sering digunakan adalah lidokain.4
Lidokain, sebelumnya juga disebut sebagai lignokain, adalah agen anestesi lokal golongan amida yang pertama kali disintesis pada tahun 1940-an oleh Nils Löfgren dan Bengt Lundquist, dengan mengembangkan turunan dari xylidine.
Selain jenisnya, pemberian anestetik lokal pada prosedur endoskopi harus dipastikan memiliki sebaran yang merata pada struktur jalan nafas atas untuk mencegah gag reflex yang diduga berasal dari reseptor yang terdapat pada lipatan palatoglossal dan palatopharyngeal, dasar lidah, palatum, uvula, dan dinding faring bagian belakang.6 Penggunaan lidokain dalam bentuk spray dan inhalasi dapat dimanfaatkan pada prosedur endoskopi saluran cerna atas, namun tentu saja pemilihan cara pemberian lidokain harus memperhatikan tingkat efektivitas dan kenyamanan pasien. Pada edisi ini, Heriwardito dkk7 membandingkan kedua cara pemberian lidokain tersebut dalam mengurangi kejadian gag reflex dan rerata rescue dose propofol yang diperlukan.
Efek Efedrin 10 mg atau Ondansetron 4 mg Sebagai Profilaksis Hipotensi Pasca Anestesi Spinal pada Seksio Sesarea: Sebuah Uji Acak Tersamar Tunggal
Authors: Holiwono Albertus Magnus Mario , Hisbullah  , Syamsul Hilal Salam  
Published: March 2022

Latar Belakang: Persalinan melalui Seksio Caesaria (SC) merupakan prosedur operasi yang semakin sering digunakan di negara berkembang saat ini. Hipotensi pasca anestesi spinal pada pembedahan Seksio Sesaria sering terjadi dan dapat menyebabkan gangguan kesadaran dan kolaps kardiovaskular. Efedrin dan Ondansetron telah dilaporkan dapat mencegah hipotensi setelah anestesi spinal. Namun, hingga saat ini masih terdapat kontroversi mengenai penggunaannya. Studi ini bertujuan untuk mengetahui pengaruh Efedrin atau Ondansetron profilaksis terhadap hipotensi pasca anestesi spinal pada pembedahan Seksio Sesarea.
Metode: Penelitian ini merupakan uji klinis acak tersamar tunggal tiga kelompok, dilakukan pada pasien yang menjalani SC pada bulan Maret hingga Juni 2020 pada RS afiliasi. Kelompok intervensi mendapatkan Efedrin 10mg atau Ondansetron 4mg intravena, dan NaCl 0.9% sebagai pembanding. Pengukuran data hemodinamik (sistol, diastol, MAP, dan laju nadi) dilakukan setiap 2 menit dalam 18 menit pertama dan dilanjutkan setiap 10 menit sampai prosedur pembedahan selesai. Kejadian efek samping mulai dicatat setelah anestesi spinal hingga 24 jam pascabedah. Jumlah rescue dengan Efedrin antar kelompok juga dicatat. Uji t berpasangan dilakukan untuk melihat perbedaan antar waktu. Uji ANOVA dilakukan untuk melihat perbedaan antar kelompok pada unit waktu dengan tingkat kepercayaan 95%
Hasil: Penurunan profil diastol dan MAP lebih sedikit pada kelompok Efedrin dan Ondansetron dibandingkan kelompok kontrol. Laju nadi lebih rendah secara umum pada kelompok Efedrin dan Ondansetron. Enam sampel pada kelompok efedrin dan ondansetron, dan sepuluh sampel pada kontrol mendapatkan rescue vasopressor. Total rescue pada kelompok efedrin, odansetron dan kontrol adalah 75mg, 110mg, dan 145mg. Total sampel yang mengalami mual pada kelompok efedrin, ondansentron, dan kotrol adalah 4 sampel, 2 sampel, dan 6 sampel.
Simpulan: Pemberian Efedrin 10mg atau Ondansetron 4mg profilaksis mengurangi hipotensi pasca spinal, mengurangi kebutuhan rescue terutama pada pemberian Efedrin, dan mengurangi kejadian mual muntah terutama pada pemberian Ondansetron.
Korelasi Kadar ScVO2 dengan Skor Sequential Organ Failure Assesment (SOFA) pada Pasien Sepsis di Intensive Care Unit (ICU) RSUD Dr. Moewardi Surakarta
Authors: Woyka Swanita , Purwoko  , Ardana  
Published: March 2022

Pendahuluan: Sepsis merupakan disfungsi organ yang mengancam jiwa yang disebabkan disregulasi respons host terhadap infeksi. ScVO2 telah dipertimbangkan sebagai faktor prognosis yang sesuai di berbagai situasi klinik pada pasien dengan sakit kritis. Skor SOFA adalah penilaian disfungsi organ yang terjadi pada sepsis. Penelitian ini bertujuan untuk mengetahui dan menganalisis korelasi kadar ScVO2 dengan skor sequential organ failure assessment (SOFA) pada pasien sepsis.
Metode: Dilakukan penelitian potong lintang terhadap 32 sampel darah dan data klinis pasien sepsis yang dirawat di ICU RSUD Dr. Moewardi di Surakarta pada bulan April-September 2018, kemudian dianalisis menggunakan program komputer dengan analisis univariat dan analisis bivariat melalui uji pearson.
Hasil: Korelasi kadar SCVO2 dengan skor SOFA mendapatkan nilai r=-0,389 dan nilai p =0,028 yang menunjukkan terdapat hubungan negatif dan signifikan antara kadar SCVO2 dengan SOFA Skor.
Kesimpulan: Terdapat korelasi antara kadar SCVO2 dengan skor Sequential Organ Failure Assesment score (SOFA score) pada pasien sepsis.
ROA, ROE, and EPS on Stock Prices in The Basic & Chemical Industry Sector Listed on The Jakarta Composite Index
Authors: Krisdayanti Sonia 
Published: March 2022

This study aims to examine the effect of Return On Assets (ROA), Return On Equity (ROE) and Earning Per Share (EPS) on Stock Prices in Manufacturing Companies in the Basic & Chemical Industry Sector Listed on the Indonesia Stock Exchange (IDX) for the 2015-2019. The sample selection in this study used purposive sampling method. The method used in this research is panel data regression analysis. The results of the research are: Return on Assets (ROA) has no a significant effect on stock prices. This is indicated by the t-count is greater than the t-table value (1.009 < 1.98), with a probability value bigger than the significance or (0.3151 > 0.05), while the Return On Equity (ROE) has no significant effect on the price share. This is indicated by the t-count is smaller than the t-table value (0.849 < 1.98), with a probability value greater than significance or (0.3978 > 0.05), then Earning Per Share (EPS) has a significant effect on stock prices. This is indicated by the t-count is greater than the t-table value (2.16 > 1.98), with a probability value smaller than the significance or (0.0331 < 0.05), and Based on the results of the F test, Return On Assets (ROA), Return On Equity (ROE) and Earning Per Share (EPS) together have a significant effect on stock prices. This is indicated by the F-count value is greater than the F-table (27.61 > 2.63), and the probability value is also smaller than the 0.05 significance level (0.0000 < 0.05).
enfrentamento da COVID-19 em um território da Estratégia Saúde da Família
Authors: Silva Aimée Giovanna da Silva , Santos Alyny Leal , Morais Wesley Ribeiro de , Fernandes William Vieira , Cunha Cassandra Santos da , Jesus Mayara Lopes de , Pinheiro Alba Lúcia Santos 
Published: March 2022

Problema: A COVID-19 configura-se como um desafio para toda a rede de saúde, e a Atenção Primária à Saúde destaca-se como um ordenador do cuidado nesse cenário. A equipe de residentes que atua em uma Unidade de Saúde da Família em Itabuna/Bahia tem buscado novas formas de planejar e desenvolver ações perante essa pandemia. Método: Trata-se de um relato de experiência sobre a operacionalização de um plano de ação elaborado pelos residentes de um território de Estratégia Saúde da Família como resposta ao contexto da pandemia da COVID-19. Resultados: Foram produzidas informações, reorganizado os fluxos na unidade, evitando as aglomerações nos serviços, garantido os equipamentos de proteção individual para os profissionais de saúde, produzido material educativo para orientar essas ações e principalmente não perdendo de vista a integralidade do cuidado ao garantir a manutenção das ações e programas anteriores. Conclusão: A adoção dessas novas medidas vem impactando positivamente o processo de trabalho, enfatizando a prevenção como eixo principal.
Morphological description and molecular identification ofMyxobolus dajiangensisn. sp. (Myxozoa: Myxobolidae) from the gill ofCyprinus carpioin southwest China
Authors: Wang Miao-miao , Zhang Jin-ye , Zhao Yuan-jun 
Published: March 2022

BackgroundMyxosporean diversity is a hot topic since they are difficult to accurately identify and classify. ManyMyxobolusparasites have been named asMyxobolus koibecause of their similar morphological features with the species originally reported. However, the distinctions in fine morphological features, host specificity, and molecular data have given rise to the attention of researchers.MethodsThe classical morphometric and histological methods were used to describe theMyxobolus dajiangensisn. sp. in morphology. The common techniques in modern molecular biology and the methods of phylogenetic analyses were combined to identify the species.ResultsPlasmodia of interlamellar-vascular type were found in the vascular network of gill lamellae. Mature myxospores ofM. dajiangensisn. sp. were elongated and pyriform from the frontal view. The myxospores were 14.8 ± 0.4 (13.9–15.6) µm in length, 8.0 ± 0.5 (7.2–9.1) µm in width, and 5.5 µm in thickness. The two polar capsules were pyriform and slightly different in length. The length of the larger polar capsules was 8.0 ± 0.4 (7.1–8.8) µm, and it was 7.4 ± 0.4 (6.1–8.0) µm for the smaller ones. The width of both polar capsules was 2.5 ± 0.2 (2.0–3.2) µm. The polar filaments within the polar capsules were each coiled nine to 11 turns. Comparative analysis of both the morphological and molecular data between the present speices and other similar species revealed that the present species is a novel species,Myxobolus dajiangensisn. sp. Also,M. koi(FJ710800) was misidentified and the congener withM. dajiangensisn. sp., depending on the secondary structures of SSU rRNA and phylogenetic analysis. Moreover, the cryptic species existed in theM. koiparasites.
Estimation of Adult Equivalent Scale for Consumption Expenditure of Food and Non-food Items with Special Reference to Fruits and Vegetables in Rural and Urban Households of Junagadh District of Gujarat
Authors: Chavda Haresh , Shiyani R. L. 
Published: March 2022

Consumption is an integral part of our life. Consumer patterns change for both micro and macro reasons. The per capita availability of vegetable was 415.76 gms/day and fruits was 228.79 gms/day in 2019-20 in India which was far below the quantity recommended by WHO. Therefore, it is important to understand changing consumption pattern of fruits and vegetables as well as food and non-food items in rural and urban areas.
The present study is based on primary data and hence the household data pertaining to the research study from Junagadh district were collected with the help of interview method. The reference period for the study was year 2019-20 i.e. winter (November-2019 to February-2020), summer (March to June-2020) and monsoon (July to October-2020). The data were analyzed using tabular analysis, regression analysis without intercept for calculating adult equivalent scale (AES)
The estimates of adult equivalent scales for main commodity group for different seasons for rural households revealed that the females in age group of 20-40 years accounted for the maximum expenditure share in total fruits and vegetables (TFV), total food (TF), total non-food (TNF) and total expenditure (TOT) commodities groups in all the seasons.
In urban households, the adolescent (13-20 years) accounted for the largest proportionate share of expenditure in in TFV commodities groups in all the seasons. For TF and TNF commodity groups, 20-40 years male age groups accounted for the highest share in expenditure in winter and summer seasons while adolescent age group (13-20 years) which accounted for the highest expenditure share in summer season. In TOT commodity group, adolescent of 13-20 years accounted for the highest proportionate share of expenditure in winter and summer seasons whereas it was females in age group of (20-40 years in monsoon season.
In overall households, the females in age group of 20-40 years accounted for the maximum expenditure share in TFV commodities groups in winter and summer seasons whereas, it was maximum in monsoon season for the males in age group of 20-40 years. For other commodity groups i.e.TF, TNF and TOT in all seasons, the female in 20-40 years age group accounted for the largest proportionate share of expenditure in different seasons.
Antibiotic Resistant Staphylococcus spp Isolates Colonizing Some College Students Laboratory Coats
Authors: Jesumirhewe Christiana , Takemebo Vera Ekankumoh , Onyenwe Nathaniel Ejikeme 
Published: March 2022

Aim: Laboratory coats may act as fomites for the continued dissemination of antibiotic resistant bacteria. This study aimed at detecting the level and type of antibiotic resistant microorganisms’ on laboratory coats of students of Dora Akunyili College of Pharmacy, Igbinedion University Okada, Edo State. Nigeria.
Place and Duration of Study: Dora Akunyili College of Pharmacy, Igbinedion University Okada, Edo State. Nigeria between September and October, 2020.
Methodology: A total of 20 pharmacy students working in various laboratories in the college were included in the study to evaluate the bacterial contamination of laboratory coats. Swabs were obtained from 3 different areas of the laboratory coat – collar, pocket, and wrist and processed in the Pharmaceutical Microbiology laboratory based on standard microbiological techniques. Antibiotic susceptibility testing was carried out on the isolates obtained by Kirby-Bauer method for 10 antibiotics.
Results: This study revealed that 83% of the coats were contaminated with Staphylococcus spp. White coats of male subjects were more contaminated than that of the female subjects and the pockets were sites which had the highest percentage of finding bacteria. Antibiotic sensitivity testing showed isolates on the laboratory coats resistant to cloxacillin, erythromycin, ceftriaxone, cefuroxime, ceftazidime, augmentin and oxacillin.
Conclusion: The detection of antibiotic resistant isolates of Staphylococcus spp from the laboratory coats of pharmacy college students suggests that the clothing may harbor pathogenic organisms. This study also highlights the importance of laboratory coats as potential source of cross infection.
Comparative Assessment of Iron Deficiency Anaemia among Chronic Kidney Disease Subjects in Niger Delta Nigeria
Authors: Tamunonengiye-ofori Lenox-Prince, , Awortu Zacchaeus Jeremiah, , Mgbeoma Eze Evelyn , Beauty Eruchi Echonwere-Uwikor, , Beatrice Moore-Igwe, , Augustina Ngozi Mordi, 
Published: March 2022

Iron Deficiency Anaemia which is reduced red blood cells due to iron deficiency had been reported to be a major challenge among Chronic Kidney Disease patients. The cause of anaemia in these patients is multifactorial, ranging from the inability of the kidneys to excrete hepcidin to even the inability of the kidneys to produce erythropoietin. This study aimed at comparatively assessing IDA between CKD and APHS in Niger Delta. A total of 88 subjects were recruited, 55(62.50%) CKDP and 33(37.50%) Control subjects. Samples were collected and analysed for IDA Indicators such as Serum Hepcidin Levels using commercial DRG Hepcidin-25 kit and other Haematological Indices using Automation (Sysmex KX-21N Automated Haematology Analyzer), Leishman Staining Technique and Supravital Staining Technique; Questionnaire was also used to obtain some data, data obtained were analysed using SPSS version 21.The mean values for Serum Hepcidin, Haemoglobin(HB), Packed Cell Volume(PCV), Red Blood Cell count(RBC), Mean Cell Volume(MCV), Mean Cell Haemoglobin(MCH), Mean Cell Haemoglobin Concentration(MCHC), Reticulocyte count(Retics) and Red Cell Distribution Width(RDW) were 52.00ng/ml, 10.00 g/dL, 31.00%, 3.74×102/L, 78.84fL, 26.58pg, 31.79g/dL, 0.64%, and 14.94% respectively in the CKD patients while that for the APHS were 16.00ng/ml, 14.00g/dL, 42.00%, 4.69×1012/L, 89.37fL, 29.59pg, 33.00g/dL, 1.09% and 13.20% respectively. Statistical T-Test of significance revealed that Serum Hepcidin level was elevated significantly in CKD patients (52.00ng/ml) when compared with APHS(16.00ng/ml) t86= 6.54, p<0.05, Haemoglobin value of 10.00g/dL in CKD patients was significantly lower than 14.00g/dL in APHS (t86 = -8.49, p<0.05), and the values of other haematological indices were lower except RDW that was elevated significantly among CKD patients when compared with the APHS (p<0.05) all at significance level of 0.05. The elevated serum hepcidin and RDW level seen in this study may be as a result of diminished renal clearance and inflammatory state of the kidney. The kidney”s inability to make enough erythropoietin may have lead to the low red blood cell count that consequently caused anaemia in subjects studied..The estimation of Serum Hepcidin level in CKD patients in addition to the other Haematological indices will improve the diagnosis, treatment and management of Iron Deficiency Anaemia in these patients.
Chronic Effects of Atypic Antipsychotics on Mice Isolated Vas Deferens Contractility: An In vitro Study
Authors: Tanyeri Mehmet Hanifi , Buyukokuroğlu Mehmet Emin , Tanyeri Pelin , Kaya Rümeysa Keleş , Bozkurt Şeyma Nur Başarir , Mutlu Oğuz , Akar Füruzan Yildiz , Erden Bekir Faruk , Ulak Guner 
Published: March 2022

Aims: Antipsychotic drugs are known to be commonly associated with sexual dysfunction. The aim of this study to investigate the effects of sertindole, asenapine and ziprasidone on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the isolated vas deferens in mice.
Study design: All the drugs were administered intraperitoneally (i.p.) in a volume of 0.1 ml per 10 g body weight of mice.
Place and Duration of Study: Department of Pharmacology, Kocaeli University, Animal Research Center, between May 2018 and August 2019.
Methodology: The mice were randomly divided into groups (n=7) as follows: saline; sertindole 1.3 mg/kg; sertindole 2.5 mg/kg; asenapine 0.05 mg/kg; asenapine 0.075 mg/kg; ziprasidone 1 mg/kg; ziprasidone 2 mg/kg once daily for 21 days. Mice receiving only the vehicle (0.9% saline, i.p.) served as control group. After 21 days of treatment, the effects of drugs were investigated on 5-HT, NA, ATP and KCl-induced contractions of isolated vas deferens.
Results: The results showed that serotonin-induced contractions of vas deferens were affected by the chronic treatments of sertindole, asenapine and ziprasidone, however these drugs had no significant effect on NA, ATP, and KCl-induced contractions of mice vas deferens.
Conclusion: Serotonergic receptors may contribute to changes in vas deferens contractions in mice with chronic treatment of sertindole, asenapine and ziprasidone. Thus, our results may explain one of the causes of sexual dysfunction of sertindole, asenapine and ziprasidone.
Bayesian network model informs on the impact of biotic and abiotic factors on the population characteristics of an endangered plant species
Authors: Sienkiewicz Aneta , Łaska Grażyna 
Published: March 2022

AbstractPreservation of the endangered plant species requires knowledge of the impact of environmental factors on their populations. This study was undertaken to evaluate the potential of a Bayesian network (BN) model to analyze the impact of habitat conditions on the current characteristics of Pulsatilla patens (L.) Mill. population in NE Poland. The model was based on field data collected in 2011–2015 from 47 sites in the four largest forest complexes of NE Poland. The causal network between (1) the biotic and (2) abiotic factors as well as morphological‐developmental features of individuals and demographic features of populations (20 attributes, 1573 records) was made using the Bayesian Search Algorithm in GeNIe 2.0. The results indicate that the greatest impact on the population features had the number of competing species in forest undergrowth and exposition of slopes. Diagnostic testing and sensitivity analysis revealed that these factors were the major variables determining the size of the population, developmental phase, and the size of individuals. Tenfold cross‐validation revealed that this model was the most effective to analyze the impact of habitat conditions on the presence of generative shoots, developmental phase, and juvenile shoots. The optimal levels of factors following from the BN modeling of the impact of habitat conditions on the characteristics of the population will allow regular growth (size of individuals) and development (life cycle of individuals) of a given endangered species.