bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coherence Scale and Directivity of Nighttime Equatorial Plasma Irregularities: Results From Swarm Formation Flight
Authors: Park Jaeheung 
Published: April 2022

AbstractSince the launch in 2013, the three satellites of the Swarm constellation have been conducting multipoint observations of ionospheric plasma density. The variety of their flight formations is advantageous for investigating (a) coherence scale and (b) directivity of nighttime Equatorial Plasma Irregularities (EPIs). In this study, we address the two topics statistically using in situ plasma density measured at 2 Hz rates by the Swarm constellation from 2013 to 2021. Maximum cross‐correlation coefficients between two Swarm density profiles decrease as longitude differences between the observation pair increase. The coefficient is larger than 0.6 only when two satellites are within about 0.1° in geographic longitude (GLON), which approximately corresponds to 10 km. When two density profiles are considerably correlated, we can determine preferred bearings of the EPI structure. A majority of EPIs conform to the backward‐C shapes astride the dip equator. The preference for backward‐C is more conspicuous later at night than in the early evening. Different GLON sectors exhibit slightly different directions of EPI structures, but the behavior is not well organized with the geomagnetic declinations of the respective sectors. EPI directions do not display monotonic dependence on Ap or F10.7, but further studies during the coming solar maximum are necessary to better represent high solar/geomagnetic activity.
Coupled Hydromechanical Modeling of Induced Seismicity From CO2 Injection in the Illinois Basin
Authors: Luu Keurfon , Schoenball Martin , Oldenburg Curtis M. , Rutqvist Jonny 
Published: April 2022

AbstractInjection of CO2 for geologic carbon sequestration into deep sedimentary formations involves fluid pressure increases that engage hydromechanical processes that can cause seismicity by activation of existing faults. In this work, we use a coupled multiphase fluid flow and geomechanical simulator to model spatiotemporal fluid pressure and stress changes in order to study the poroelastic effect of CO2 injection on faults in crystalline basement rock below the injection zone. The seismicity rate along features interpreted to be basement faults is modeled using Dieterich's rate‐and‐state earthquake nucleation model. The methodology is applied to microseismicity detected during CO2 injection into the Mount Simon formation during the Illinois Basin—Decatur Project. The modeling accurately captures an observed reduction in seismicity rate when the injection in the second well was into a slightly shallower zone above the base of the Mount Simon formation. Moreover, the modeling shows that it is important to consider poroelastic stress changes, in addition to fluid pressure changes for accurately modeling of the observed seismicity rate.
Impact of SST on Present and Future Extreme Precipitation in Hokkaido Investigated Considering Weather Patterns
Authors: Hatsuzuka Daisuke , Sato Tomonori 
Published: April 2022

AbstractThis study investigated the impact of sea surface temperature (SST) on extreme precipitation events in North Japan and its relation to synoptic weather patterns using large‐ensemble climate simulations. Eight weather patterns were identified by applying cluster analysis to sea level pressure anomalies for selected days with extreme precipitation derived from a 3000‐year historical climate experiment. Interannual variability of extreme precipitation days associated with two specific weather patterns, characterized by a weak low‐pressure system and an atmospheric river (AR), significantly correlated with that of SST over the Sea of Japan, with a correlation coefficient of 0.37 and 0.53, respectively. In higher SST years, the increased atmospheric moisture can increase the extreme precipitation in the inland area of Hokkaido for the weather pattern associated with a weak low‐pressure system, whereas it appears to enhance orographic precipitation along the western slopes of mountains for the pattern resembling AR. These results indicate that the effect of local SST on extreme precipitation strongly depends on the weather patterns. In the future projection, the two weather patterns that are sensitive to SST over the Sea of Japan show a sharp increase of more than 4 times under the 4 K warming climate. Moreover, the magnitude of extreme precipitation was also found to increase with SST, broadly following the Clausius–Clapeyron relation in both historical and warmed climates. These results suggest increased risk of heavy precipitation associated with such weather patterns over North Japan in the future.
The Effects of Terrain Properties Upon the Small Crater Population Distribution at Giordano Bruno: Implications for Lunar Chronology
Authors: Williams J.‐P. , Pathare A. V. , Costello E. S. , Gallinger C. L. , Hayne P. O. , Ghent R. R. , Paige D. A. , Siegler M. A. , Russell P. S. , Elder C. M. 
Published: April 2022

AbstractThe distribution of impact craters on the ejecta of Giordano Bruno, a recent (<10 Ma) 22‐km diameter crater within the lunar highlands, exhibits substantial variations. We surveyed craters D ≥ 10 m across a 1,323 km2 area of Giordano Bruno's ejecta and compared the distribution of craters with variations in thermophysical properties derived from the Lunar Reconnaissance Orbiter Diviner instrument. We used Diviner‐derived rock abundance and nighttime regolith temperatures along with thermal model‐predicted surface temperatures for a diversity of terrains to identify and isolate areas of the ejecta based on thermophysical properties such as bulk density and thermal conductivity. We found that thermophysical properties of the ejecta vary considerably both laterally and vertically, and consistently differ from typical regolith, indicating the presence of higher thermal inertia materials. Crater‐size frequencies are significantly lower in areas with terrain properties exhibiting higher: rock abundance, nighttime temperatures, and/or modeled thermal inertia. This discrepancy in crater distribution increases for craters smaller than ∼25 m. These thermophysical variations indicate changes in the mechanical properties of the target materials. We suggest that these variations—specifically, terrain‐dependent crater scaling variations and impactor‐scale heterogeneities in material properties such as the presence or absence of large boulders—may influence crater diameters or inhibit crater production altogether in Giordano Bruno's ejecta; furthermore, these factors are size‐dependent.
Reply to Comment by A.P. Nutman et al. on “Tectonics of the Isua Supracrustal Belt 1: P‐T‐X‐d Constraints of a Poly‐Metamorphic Terrane” by A. Ramírez‐Salazar et al. and “Tectonics of the Isua Supracrustal Belt 2: Microstructures Reveal Distributed Strain in the Absence of Major Fault Structures” by J. Zuo et al.
Authors: Ramírez‐Salazar Anthony , Zuo Jiawei , Müller Thomas , Webb A. Alexander G. , Sorger Dominik , Piazolo Sandra , Haproff Peter , Harvey Jason , Wang Qin , Hauzenberger Christoph , Wong Tsz Kin 
Published: April 2022

AbstractStructural and metamorphic analyses from the works under discussion (Ramírez‐Salazar et al., 2021, https://doi.org/10.1029/2020tc006516; Zuo et al., 2021, https://doi.org/10.1029/2020tc006514) show that the Isua supracrustal rocks can be interpreted to record one single deformation and metamorphic event featuring quasi‐homogeneous deformation and amphibolite facies metamorphism, followed by late static retrogression or thermal event(s). Observed deformation and metamorphic records are consistent with three hypotheses: (a) they represent Neoarchean plate tectonic overprints following Eoarchean plate tectonic evolution (e.g., Nutman et al., 2022, https://doi.org/10.1029/2021TC007036); (b) they represent Eoarchean heat‐pipe and/or plate tectonic deformation that survived later tectonic event(s) (e.g., Ramírez‐Salazar et al., 2021, https://doi.org/10.1029/2020tc006516; Zuo et al., 2021, https://doi.org/10.1029/2020tc006514), and; (c) they represent one major Neoarchean tectonic event, such that the Isua supracrustal belt (ISB) records Eoarchean protolith‐related processes but does not record Eoarchean metamorphism nor deformation. While a heat‐pipe model for crustal formation is central to hypothesis 2, it is also a viable crustal formation mechanism for hypothesis 3 where the ISB would still form in a heat‐pipe setting in Eoarchean time, but the major deformation of the heat‐pipe lithosphere happened during Neoarchean time, probably by (proto‐)plate tectonic processes. If the data presented in Zuo et al. (2021), https://doi.org/10.1029/2020tc006514 and Ramírez‐Salazar et al. (2021), https://doi.org/10.1029/2020tc006516 only reflect Neoarchean histories, then these cannot be used to refute or support any Eoarchean geodynamic background for the formation of the ISB.
The Role of Prior Probabilities on Parameter Estimation in Hydrological Models
Authors: Gupta A. , Govindaraju R. S. , Morbidelli R. , Corradini C. 
Published: April 2022

AbstractBayes theorem provides a formal framework for combining prior and sample information for parameter estimation in the presence of measurement and structural errors. Prior knowledge, however, may not always be available or may be too vague to incorporate into a prior distribution. In such cases, a reference prior must be chosen for an objective analysis. Typically, a uniform density over the possible ranges of parameters is chosen as the reference prior. However, the validity of a uniform prior as a reference prior is seldom questioned. In this study, an information‐theoretic approach is pursued to derive reference priors, and the results are compared to those obtained by using a uniform prior. Examples of estimating saturated hydraulic conductivity are presented. Priors over hydraulic conductivity obtained by using the information‐theoretic approach are transformation‐invariant and typically nonuniform. The choice between information‐theoretic and uniform prior influences the posterior distribution of hydraulic conductivity, when sample information is small. The use of reference prior is also demonstrated through the PDG‐GIUH hydrologic model, and issues of computational tractability are addressed.
A Catchment‐Based Hierarchical Spatial Tessellation Approach to a Better Representation of Land Heterogeneity for Hyper‐Resolution Land Surface Modeling
Authors: Huang Lina , Zhang Shupeng , Niu Guo‐Yue , Wei Nan , Yuan Hua , Wei Zhongwang , Lu Xingjie , Peng Jingman , Li Wenyao , Dai Yongjiu 
Published: April 2022

AbstractTo represent the physical processes at hillslope scales for hyper‐resolution land surface modeling, we propose a hierarchical, catchment‐based spatial tessellation method. The land surface is divided into a hierarchical structure: catchments, height bands along hillslopes within a catchment, and land cover patches within a height band. This catchment‐based structure explicitly represents hillslope drainage networks and can be applied at various resolutions determined by a pre‐defined maximum height band size. The proposed tessellation method is superior to the conventional grid‐based structure in representing land surface heterogeneity, resulting in a higher aggregation skill through the height band representation. The spatial variations in air temperature, leaf area index, saturated soil hydraulic conductivity, and soil porosity are generally lower within a height band than those in a conventional rectangular grid, reflecting the nature of topographic control on climate, vegetation, and soil distribution. The improvement in aggregation skill depends on resolutions and terrain slope angle, more pronounced at 1/6° model resolution and over steeper terrains. Finally, we demonstrate that our proposed catchment‐based structure performs better than the grid‐based structure through modeling tests over the Columbia River basin at resolutions of 1/2°, 1/6°, and 1/20° and a global test at 1/2° using the ILAMB model evaluation metrics.
Spatio‐Temporal Model Variance‐Covariance Approach to Assimilating Streamflow Observations Into a Distributed Landscape Water Balance Model
Authors: Tian Siyuan , Renzullo Luigi J. , Lerat Julien , Pipunic Robert C. 
Published: April 2022

AbstractAccurate initial conditions play a critical role in improving predictive accuracy of hydrological models for quantities such as streamflow generation. Streamflow observations from in situ gauging sites have been assimilated in a wide range of past research to improve lumped catchment streamflow. However, spatio‐temporal state updating in distributed hydrological models through streamflow data assimilation (DA) remains a challenge due to the large dimensional disparity between model state space and observation space. This study explores the use of model spatio‐temporal variance‐covariance from simulated climatology as a surrogate for model error, as a way of distributing constraint from gauge measurements spatially. In the approach developed here, grid cells within and surrounding gauged catchments were updated simultaneously. The proposed DA method leads to a substantial improvement in performance and reliability compared to open‐loop (OL) estimates of streamflow. In particular, for “ungauged” catchments updated using streamflow observations from neighboring catchments, the mean absolute error (MAE) was reduced by 20% on average after the assimilation. In addition, improvements from using the analyzed states as initial conditions were found to persist for more than 1 week, and even longer for catchments with high annual runoff. The improvement in streamflow forecasts using initial conditions from DA can be more than 40% in terms of MAE compared to OL results for 1 day lead time, and more than 10% for 5 days lead time.
Microbial Sulfate Reduction (MSR) as a Nature‐Based Solution (NBS) to Mine Drainage: Contrasting Spatiotemporal Conditions in Northern Europe
Authors: Fischer Sandra , Mörth Carl‐Magnus , Rosqvist Gunhild , Chalov Sergey R. , Efimov Vasiliy , Jarsjö Jerker 
Published: April 2022

AbstractAn emerging solution in mine waste remediation is the use of biological processes, such as microbial sulfate reduction (MSR), to immobilize metals, reducing their bioavailability and buffering the pH of acid mine drainage. Apart from laboratory tests and local observations of natural MSR in, for example, single wetlands, little is known about spatiotemporal characteristics of freshwater MSR from multiple locations within entire hydrological catchments. We here applied an isotopic fractionation (δ34S values in SO42−) and a Monte Carlo‐based mixing analysis scheme to detect MSR and its variation across two major mining regions (Imetjoki, Sweden and Khibiny, Russia) in the Arctic part of Europe under different seasonal conditions. Results indicate a range of catchment‐scale MSR values in the Arctic of ∼5%–20% where the low end of the range was associated with the non‐vegetated, mountainous terrain of the Khibiny catchment, having low levels of dissolved organic carbon (DOC). The high end of the range was related to vegetated conditions provided by the Imetjoki catchment that also contains wetlands, lakes, and local aquifers. These prolong hydrological residence times and support MSR hot spots reaching values of ∼40%. The present results additionally show evidence of MSR persistence over different seasons, indicating large potential, even under relatively cold conditions, of using MSR as part of nature‐based solutions to mitigate adverse impacts of (acid) mine drainage. The results call for more detailed investigations regarding potential field‐scale correlations between MSR and individual landscape and hydroclimatic characteristics, which, for example, can be supported by the isotopic fractionation and mixing scheme utilized here.
Global Increases in Compound Flood‐Hot Extreme Hazards Under Climate Warming
Authors: Gu Lei , Chen Jie , Yin Jiabo , Slater Louise J. , Wang Hui‐Min , Guo Qiang , Feng Maoyuan , Qin Hui , Zhao Tongtiegang 
Published: April 2022

AbstractUnder global warming, a novel category of extreme events has become increasingly apparent, where flood and hot extremes occur in rapid succession, causing significant damages to infrastructure and ecosystems. However, these bivariate compound flood‐hot extreme (CFH) hazards have not been comprehensively examined at the global scale, and their evolution under climate warming remains unstudied. Here, we present the first global picture of projected changes in CFH hazards by using a cascade modeling chain of CMIP6 models, satellite and reanalysis data sets, bias correction, and hydrological models. We find an increasing percentage of floods will be accompanied by hot extremes under climate change; the joint return periods of CFHs are projected to decrease globally, particularly in the tropics. These decreasing joint return periods are largely driven by changes in hot extremes and indicate a likely increase of CFH hazards, and ultimately highlight the urgent need to conduct adaptation planning for future risks.
c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
Authors: Wang Xu-Yan , Wei Yuan , Hu Bo , Liao Yuan , Wang Xiaodong , Wan Wen-Hua , Huang Chun-Xiang , Mahabati Mahepali , Liu Zheng-Yu , Qu Jing-Rui , Chen Xiao-Dan , Chen Dong-Ping , Kuang Dong-Ming , Wang Xue-Hao , Chen Yun 
Published: April 2022

AbstractB cells secreting IL-10 functionally are recognized as functional regulatory B (Breg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting Breg cells in humans is still lacking. Here, we demonstrate that, although IL-10 itself is anti-inflammatory, IL-10+ functional Breg cells in patients with systemic lupus erythematosus (SLE) display aggressive inflammatory features; these features shift their functions away from inducing CD8+ T cell tolerance and cause them to induce a pathogenic CD4+ T cell response. Functional Breg cells polarized by environmental factors (e.g., CPG-DNA) or directly isolated from patients with SLE mainly exhibit a CD24intCD27−CD38−CD69+/hi phenotype that is different from that of their precursors. Mechanistically, MAPK/ERK/P38-elicited sequential oncogenic c-Myc upregulation and enhanced glycolysis are necessary for the generation and functional maintenance of functional Breg cells. Consistently, strategies that abrogate the activity of ERK, P38, c-Myc, and/or cell glycolysis can efficiently eliminate the pathogenic effects triggered by functional Breg cells.
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques
Authors: Deng Wei , Lv Qi , Li Fengdi , Liu Jiangning , Song Zhiqi , Qi Feifei , Wei Qiang , Yu Pin , Liu Mingya , Zhou Shasha , Zhang Yaqing , Gao Hong , Wang Nan , Jia Zijing , Gao Kai , Liu Jiayi , Xiao Chong , Shang Haiquan , Wang Xiangxi , Bao Linlin , Qin Chuan 
Published: April 2022

AbstractVariants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine, or a bivalent inactivated vaccine (Beta and Delta) to determine the effectiveness of sequential immunization. The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron. Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron. These results suggest that sequential immunization of inactivated vaccines or polyvalent vaccines could be a potentially effective countermeasure against newly emerging variants.
Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer’s disease-associated genetic variants
Authors: He Liang , Loika Yury , Kulminski Alexander M. 
Published: April 2022

AbstractElucidating regulatory effects of Alzheimer’s disease (AD)-associated genetic variants is critical for unraveling their causal pathways and understanding the pathology. However, their cell-type-specific regulatory mechanisms in the brain remain largely unclear. Here, we conducted an analysis of allele-specific expression quantitative trait loci (aseQTLs) for 33 AD-associated variants in four brain regions and seven cell types using ~3000 bulk RNA-seq samples and >0.25 million single nuclei. We first develop a flexible hierarchical Poisson mixed model (HPMM) and demonstrate its superior statistical power to a beta-binomial model achieved by unifying samples in both allelic and genotype-level expression data. Using the HPMM, we identified 24 (~73%) aseQTLs in at least one brain region, including three new eQTLs associated with CA12, CHRNE, and CASS4. Notably, the APOE ε4 variant reduces APOE expression across all regions, even in AD-unaffected controls. Our results reveal region-dependent and exon-specific effects of multiple aseQTLs, such as rs2093760 with CR1, rs7982 with CLU, and rs3865444 with CD33. In an attempt to pinpoint the cell types responsible for the observed tissue-level aseQTLs using the snRNA-seq data, we detected many aseQTLs in microglia or monocytes associated with immune-related genes, including HLA-DQB1, HLA-DQA2, CD33, FCER1G, MS4A6A, SPI1, and BIN1, highlighting the regulatory role of AD-associated variants in the immune response. These findings provide further insights into potential causal pathways and cell types mediating the effects of the AD-associated variants.
Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death
Authors: Zander David Y. , Burkart Sandy S. , Wüst Sandra , Magalhães Vladimir G. , Binder Marco 
Published: April 2022

AbstractProperly responding to DNA damage is vital for eukaryotic cells, including the induction of DNA repair, growth arrest and, as a last resort to prevent neoplastic transformation, cell death. Besides being crucial for ensuring homeostasis, the same pathways and mechanisms are at the basis of chemoradiotherapy in cancer treatment, which involves therapeutic induction of DNA damage by chemical or physical (radiological) measures. Apart from typical DNA damage response mediators, the relevance of cell-intrinsic antiviral signaling pathways in response to DNA breaks has recently emerged. Originally known for combatting viruses via expression of antiviral factors including interferons (IFNs) and establishing of an antiviral state, RIG-I-like receptors (RLRs) were found to be critical for adequate induction of cell death upon the introduction of DNA double-strand breaks. We here show that presence of IRF3 is crucial in this process, most likely through direct activation of pro-apoptotic factors rather than transcriptional induction of canonical downstream components, such as IFNs. Investigating genes reported to be involved in both DNA damage response and antiviral signaling, we demonstrate that IRF1 is an obligatory factor for DNA damage-induced cell death. Interestingly, its regulation does not require activation of RLR signaling, but rather sensing of DNA double-strand breaks by ATM and ATR. Hence, even though independently regulated, both RLR signaling and IRF1 are essential for full-fledged induction/execution of DNA damage-mediated cell death programs. Our results not only support more broadly developing IRF1 as a biomarker predictive for the effectiveness of chemoradiotherapy, but also suggest investigating a combined pharmacological stimulation of RLR and IRF1 signaling as a potential adjuvant regimen in tumor therapy.