bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and prognosis of connective tissue disease-associated pulmonary arterial hypertension
Authors: Li Meiqi , Zhang Qingfeng , Xiang Weizhen , Dong Rongrong , Yan Suyan , Ma Zhenzhen , Yang Qingrui 
Published: November 2022

Abstract
Background
Pulmonary arterial hypertension (PAH) is a series of clinicopathological syndromes associated with elevated pulmonary arterial pressure caused by various reasons, and is also the most serious complication of connective tissue disease (CTD). This study aims to evaluate the clinical features and prognostic factors of CTD associated PAH (CTD-PAH) patients in the Chinese Han population, and provide a reference basis for improving their prognosis.
Methods
A total of 392 individuals with CTD between January 2017 and August 2021 were included in this study. They were divided into two main groups: CTD-PAH and CTD-non-PAH. The independent sample t-test and Mann-Whitney U test were used to compare clinical and laboratory findings. Receiver operating characteristic (ROC) curves were converted into binary variables to determine the critical value. A Kaplan-Meier survival analysis was used to compare the survival rates of the two groups. And an analysis of death risk factors was conducted using Cox regression.
Results
In this study, SLE was the most common underlying disease among Chinese Han patients with CTD-PAH (51.56%). The level of anti-U1-RNP antibodies was significantly higher in the CTD-PAH group as compared to the CTD-non-PAH group (P = 0.001), whereas the levels of anti-SCL-70 antibodies were lower (P < 0.001). CTD patients with higher anti-U1-RNP antibodies levels were at high risk for PAH (P = 0.021), whereas higher levels of anti-U1-RNP have also been linked to decreased mortality in CTD-PAH (P < 0.001). In addition, the anti-SCL-70 antibody was an independent protective factor for CTD-PAH (P = 0.029). The poor prognosis of CTD-PAH was associated with high RDW (P = 0.010), NLR (P < 0.001), CAR (P = 0.001) and pulmonary infection (P = 0.008).
Conclusion
Patients with CTD who have higher levels of anti-U1-RNP antibodies are at high risk for PAH, whereas higher levels of anti-U1-RNP antibodies have also been linked to decreased mortality. An increase in the anti-SCL-70 antibody levels is an independent protective factor against CTD-PAH. High CAR, NLR, RDW and pulmonary infection are also significant determinants of total mortality in patients with CTD-PAH.
Performance and Economic Efficiency of Bovans Brown Laying Hens Supplemented With Effective Microorganisms
Authors: Yitbarek Melkamu Bezabih 
Published: November 2022

Abstract
Background
Effective Microorganisms is the mixed cell culture composed of photosynthetic bacteria, actinomyces, yeast, lactobacillus and fungi which improves growth rate, feed efficiency, egg production and increases the health status of poultry. The experiment was conducted to evaluate the economic efficiency of effective microorganism’s supplementation to Bovans Brown laying hens.
Results
The result revealed that layers fed in T4 (124.07g) was significantly higher (P < 0.05) than T1 (119.67g), T2 (122.36g) and T3 (122.37g). The total egg production during the experimental period (week 20 to week 67) was 241,242,249 and 268 for T1, T2, T3 and T4, respectively. The highest (P < 0.05) feed conversion ratio was observed in T4 (2.23). The total feed cost was T1 > T2 > T3 > T4. The highest net revenue was obtained from T4 and the lowest was T1 and T2. The economic efficiency was ranged from 0.66 to 0.90 and the feed cost ratio was ranged from 1.66 to 1.90 ETB.
Conclusion
Therefore, from this study it can be concluded that supplementation of EM with drinking water and in feed (T4) had the best production performance indices among the treatment groups.
A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with endometrial cancer
Authors: Tu Yuan , Jiang Peng , Wang Jinyu , Huang Yuzhen , Kong Wei , Li Ning , Zheng Yunfeng , Zhou Qian , Gou Shikai , Tian Chenfan , Yuan Rui 
Published: November 2022

Abstract
Background
Systemic Inflammation Response Index (SIRI) has been reported as an effective biomarker to predict prognosis in various cancers. However, the prognostic value of SIRI in endometrial cancer remains unclear. This study aimed to investigate the potential prognostic significance of SIRI in patients with endometrial cancer.
Methods
A total of 586 patients with endometrial cancer who underwent radical surgical treatment was retrospectively recruited from the First Affiliated Hospital of Chongqing Medical University. Univariate and multivariate analysis were used to select parameters related to recurrence of patients with endometrial cancer. The optimal threshold of SIRI was assessed by receiver operating characteristic curve. Patients were divided into low-SIRI and high-SIRI groups according to the optimal SIRI cut-off value. The differences of clinicopathological parameters and survival analysis between the low-SIRI and high-SIRI groups were compared.
Results
Multivariate analysis indicated that SIRI was an independent predictor for recurrence and death of endometrial cancer. The optimal threshold of SIRI for predicting recurrence and death of endometrial cancer was 1.29. Endometrial cancer patients in low-SIRI group had better prognosis than those in the high-SIRI group (P < 0.001). Among the 231 patients without adjuvant therapy, patients in the low-SIRI group had longer recurrence-free survival and overall survival than those in the high- SIRI group (P = 0.004, P = 0.003).
Conclusions
SIRI was identified as an independent prognostic factor for endometrial cancer. Endometrial cancer patients with higher SIRI had a worse prognosis. High-SIRI could be a prognostic stratification factor for endometrial patients.
Effects of different water quality regulators on growth performance, immunologic function and domestic water quality of GIFT tilapia (Oreochromis niloticus, GIFT strain)
Authors: Wang Liang-Gang , Liu Meng-Qian , Xie Xiao-Dong , Sun Yu-Bo , Zhang Ming-Lin , Zhao Yi , Chen Qi , Ding Yi-Qu , Yu Mei-Ling , Liang Zheng-Min , Hu Ting-Jun , Liang Wan-Wen , Wei Ying-Yi 
Published: November 2022

Abstract
Potassium monopersulfate (KMPS), tetrakis hydroxymethyl phosphonium sulfate (THPS), bacillus subtilis (BS) and chitosan (CS) are four new types of water quality regulators, which play an important role in aquaculture. In the 35-day Oreochromis niloticus (GIFT tilapia) feeding trial, all four drugs could slow down the increasing rate of ammonia nitrogen, nitrite, active phosphate and harmful substances of water in the process of GIFT tilapia culture. At the same time, the growth performance, organ index, blood physiology and biochemistry were improved, acid phosphatase (ACP), alkaline phosphatase (AKP), superoxide dismutase activity (SOD) and total antioxidant capacity(T-AOC) of serum were increased, and feed coefficient (CF) was reduced. In KMPS and THPS groups, the contents of glutamic oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT) and creatinine (Cr) of serum were significantly increased, and the hepato-somatic index (HSI) was significantly decreased during the whole feeding process. In KMPS and THPS groups, the histomorphology of liver showed obvious pathological changes. The results showed that KMPS, THPS, BS and CS could effectively improve the water quality, growth performance and immune function of GIFT tilapia. Nevertheless, frequent use of KMPS and THPS will adversely affects organ and tissue of GIFT tilapia.
The efficacy and safety of radiofrequency ablation in the treatment of inoperable patients with pulmonary malignant nodules
Authors: Qie Peng , Xun Xuejiao , Nie Xiaodong , Yin Qifan , Cui Hongshang , Liu Lijun , Wang Huien 
Published: November 2022

Abstract
Objective: Radiofrequency ablation(RFA) has been recently applied as an alternative treatment in the patients with pulmonary malignancies. The aim of our study was to assess the incidence of complications and survival rate of RFA for malignant lung nodules, and evaluate the efficacy and safety of RFA in the treatment of inoperable patients with pulmonary malignant nodules.
Methods: The clinical data of 50 patients (34 men and 16 women) aged 74.2(range 65-84) years with primary(n=42) and metastatic(n=8) lung malignant nodules treated with RFA from June 2015 and July 2017 in Hebei General Hospital were considered for this study, and the characteristics and clinical data of these patients were analyzed. Complications, progression-free survival, and overall survival at 1, 2 and 5 years of these patients were evaluated.
Results: Following the procedure. There were no major complications and deaths during the operation. 26(52%) patients presented mild-to-moderate chest pain that was easily controlled by analgesic drugs. 8(16%) patients with pneumothorax, 4(8%) haemoptysis, 6(12%) pneumonia, 7(14%) pleural effusion, and 1(2%) postoperative bronchopleural fistula. Needle-track implantation was observed in 2(4%) patients. Median progression-free survival(PFS) was 24.6 months(range, 6.8-60 months). The PFS at 1, 2, 5 years was 76%, 52%, and 20% respectively. Median overall survival(OS) was 35.5 months (range 10.2-60 months). The OS at 1, 2, and 5 years was 80%, 58%, and 32%, respectively.
Conclusion: RFA is a safe and effective alternative treatment for the inoperable patients with primary or metastatic pulmonary malignant nodules. The clinical impact and long-term results of RFA need to be further confirmed in a larger series of patients, and RFA should ideally be compared with surgery.
Prescription Pattern Analysis of Type 2 Diabetes Mellitus: A Cross-Sectional Study in Isfahan, Iran
Authors: Ziad Elnaz , Malekpour Mohammad-Reza , Farzadfar Farshad , Sadat Somayeh 
Published: November 2022

Abstract
Background
Patients with Type 2 Diabetes Mellitus (T2DM) are at a higher risk of polypharmacy and more susceptible to irrational prescriptions; therefore, pharmacological therapy patterns are important to be monitored. The primary objective of this study was to highlight the current prescription patterns in TD2M patients and compare them with the existing standards of medical care in diabetes. The second objective was to analyze whether age and gender affect prescription patterns.
Methods
This cross-sectional study was conducted using Iran Health Insurance Organization (IHIO) prescription database. It was mined by an Association Rule Mining (ARM) technique, named FP-Growth, in order to find co-prescribed drugs with anti-diabetic medications. The algorithm was implemented on different levels of Anatomical Therapeutic Chemical (ATC) classification system, which assigns different codes to drugs based on their anatomy, pharmacological, therapeutics and chemical properties, to provide in-depth analysis of co-prescription patterns.
Results
Altogether the prescriptions of 914,652 patients, out of which 91,505 were diabetic, were analyzed. According to our results, prescribing Lipid Modifying Agents (C10) (56.3%), Agents Acting on The Renin-Angiotensin System (C09) (48.9%), Antithrombotic Agents (B01) (35.7%), and Beta Blocking Agents (C07) (30.1%) were meaningfully associated with the prescription of Drugs Used in Diabetes. Our study also revealed that female diabetic patients have a higher chance of taking Antithyroid agents, and the older the patients were, the more they were prone to take neuropathy-related medications.
Conclusions
Almost all of the association rules found in this research were clinically meaningful, proving the potential of ARM for co-prescription pattern discovery. Moreover, implementing level-based ARM was effective for detecting difficult-to-spot rules. Additionally, the majority of drugs prescribed by physicians were consistent with the Standards of Medical Care in Diabetes.
Alteration of the resting-state brain networks: a multi-aspect study of functional and effective connectivity in Parkinson's disease
Authors: Ahmadimehr Shakiba 
Published: November 2022

Abstract
Purpose
Parkinson disease (PD) is known as the second most common and growing neurodegenerative disorder in the world. It is widely known that the appearance of motor and non-motor symptoms causes disorders in the brain network of such patients.
Methods
This study evaluates the brain connectivity of PD patients' (n = 15) in comparison with healthy individuals (n = 15) using functional magnetic resonance imaging (fMRI). First, independent component analysis (ICA) was implemented on the preprocessed data to extract resting-state networks (RSNs) as functional connectivity (FC) for evaluating intra-network connectivity values. Granger causality analysis (GCA) and transfer entropy (TE) are extracted as effective connectivity (EC) methods for assessing the network and regional time courses for assessing inter and intra-network connectivity measures. Finally, F-test was used to find the discriminative regions between the groups.
Results
Thirty ICA maps were identified as independent components, and seven were selected as RSNs. In terms of spatial maps, we found that patients had altered connectivity between Auditory and dorsal Default Mode Network. Several networks and regions were also discriminative between the groups in inter and intra network connectivity analysis, respectively.
Conclusions
The results show that EC methods such as GCA and TE are promising in extracting local information of PD. The reason can be considered in terms of being directional and causal in this type of connectivity, which is in relation to the concept of neuronal substrates. Also, TE might be more accurate than GCA, since TE is nonlinear which is consistent with the nature of the data. To the best of our knowledge, there was not any research that employed EC and ICA on Parkinson's resting-state fMRI data, and analyzed it using ICA time courses as well as regional time series.
An isomorphic valency transition in SmTe film enabling nonvolatile resistive change
Authors: Hatayama Shogo , Mori Shunsuke , Saito Yuta , Fons Paul , Shuang Yi , Sutou Yuji 
Published: November 2022

Abstract
A NaCl-type SmTe film showed remarkable electrical contrast (> 105) between as-deposited and annealed films in the absence of a transition in the crystal structure. A rigid-band shift induced by a valency transition between Sm2+ and Sm3+ was found to give rise to significant change in the electronic structure along with a concomitant resistivity change. Moreover, operation of a SmTe-based memory device was demonstrated by a standard measurement scheme with switching driven by electrical pulse-induced Joule heating. Since SmTe remains crystalline in both resistive states, resistance drift is suppressed offering improved readout reliability. Furthermore, the SmTe films were found to exhibit much better data retention, maintaining data for 10 years at 262 °C in contrast to conventional nonvolatile recording material such as Ge-Sb-Te (85-110 °C). The use of a valency transition reveals a new approach to the development of nonvolatile high performance resistive change materials.
Effect of post-milling process on the oxidation on the rice bran
Authors: Najamuddin Ulfah , Gorji Sara Ghorbani , Fitzgerald Melissa 
Published: November 2022

Abstract
The rancidity of rice bran is predominantly triggered by lipophilic enzyme activities. Bran stabilisation and defatting are the typical processes to inactivate the processes that cause rancidity. However, little is known about how this impacts the development of volatile compounds related to odour in the rice bran. The effects of post-milling treatments, including the stabilisation and defatting process, on the nutritional properties and then on the development of secondary volatile oxidation compounds in the rice bran during storage were investigated. Butanal, hexanal, 2 hexenal, butanoic acid, hexanoic acid, pentanoic acid, and heptanoic acid were the discriminant volatile compounds in the non-defatted bran that were identified as the markers of rancidity of non-defatted stabilised rice. It can thus be suggested that the defatting process positively contributed to the low abundance of volatile oxidation products that are responsible for bran rancidity by slowing down the formation of lipid-derived oxidation products.
Platelet to lymphocyte ratio is a risk factor for failure of non-operative treatment of colonic diverticulitis
Authors: Kim Jong Ho , Han Sang Hyup , Lee Jin-Won , Kim Haesung , Han Jeonghee 
Published: November 2022

Abstract
Introduction:
Non-operative treatment is the mainstay of colonic diverticulitis, but some patients require surgery due to non-operative treatment failure. This study aims to identify risk factors for the failure of non-operative treatment of colonic diverticulitis.
Methods:
From January 2011 to December 2020, we retrospectively reviewed 2362 patients with non-operative treatment for first-attack acute diverticulitis. Patients were categorized into non-operative treatment success or failure groups. Clinical characteristics and serum inflammatory markers were analyzed by multivariable logistic regression to determine risk factors for non-operative treatment failure of colonic diverticulitis.
Results:
Overall, 2.2% (n = 50) of patients underwent delayed surgery within 30 days (median 4.0 [ 3.0; 8.0]) due to non-operative treatment failure. Multivariable logistic regression identified that platelet to lymphocyte ratio (odds ratio [OR], 4.2; 95% confidence interval [CI], 0.05–0.13; p < 0.001), diabetes mellitus (OR, 2.2; 95% CI, 0.01–0.09; p = 0.025), left-sided colonic diverticulitis (OR, 4.1; 95% CI, 0.04–0.13; p < 0.001), and modified Hinchey classification (OR, 6.2; 95% CI, 0.09–0.17; p< 0.001) were risk factors for non-operative treatment failure.
Conclusions:
Platelet to lymphocyte ratio (PLR) is a potential risk factor for the non-operative treatment failure of acute first-attack colonic diverticulitis. Therefore, patients with higher PLR during non-operative treatment should be monitored with special caution.
Deep sea cold seep is an atmospheric Hg sink and MeHg source
Authors: Li Jiwei , Dong Xiyang , Tang Yongjie , Zhang Chuwen , Yang Yali , Zhang Wei , Liu Shanshan , Feng Xinbin , Shang Lihai , Peng Xiaotong 
Published: November 2022

AbstractMercury (Hg) is an important element in seafloor cold seeps that might govern methane emission. However, so far, the knowledge of biogeochemical Hg cycle in it remains poorly understood. In this study, Hg geochemical characteristics and microorganisms involved in Hg biogeochemical cycling were examined in three (active, inactive seep vs reference) different types of sediments sampled from the Haima cold seep in the South China Sea. Sediments in the active seep area were significantly enriched in mercury and methylmercury (MeHg) compared to the reference. Accordingly, abundant genes related to Hg methylation (hgcAB), demethylation (merB) and reduction (merA) were detected in the active seep sediments, phylogenetically associated with various bacterial and archaeal linages (e.g.Desulfobacterota, GammaproteobacteriaandHalobacteriota). Hg odd-mass number isotopes (Δ199Hg and Δ201Hg) pointed to their source from the upper ocean and the occurrence of abiotic dark oxidation. The δ202Hg values indicate Hg mass fractionation, migration and transformation in the active seep sediments. These geochemical and microbial data highlight active Hg biogeochemical cycles in seafloor cold seeps, functioning as important Hg-sinks and MeHg sources in the deep ocean.
Eco-Friendly Synthesis and Characterization of Plate-Like Fe doped SrBi4Ti4O15 by Molten Salt Method
Authors: Prasetyo Anton 
Published: November 2022

Abstract
The molten salt method is one of the eco-friendly synthesized compound which releases the minimum amount of toxic chemicals. In addition, the molten salt method also have morphology tuning ability, therefore it gives a better opportunity for compound synthesizing. SrBi4Ti4O15 is a four-layer member of the Aurivillius compound, and one of the interesting properties of SrBi4Ti4O15 is photocatalyst. Doped with metal element is strategy to reduced band gap energy of photocatalyst material as purposes to increase its utilization under a wider visible light spectrum. Here in, Fe doped SrBi4Ti4O15 was synthesized using Na2SO4/K2SO4 molten salt method. The diffractogram of all samples revealed that all samples were successfully synthesized in the A21am space group with no impurity phase. Raman spectra confirmed the existence of typical Raman vibration peak for a four-layer Aurivillius family compound. SEM images showed that the Fe doped SBT particle shape is plate-like, and there are no agglomerations formed. Meanwhile, the UV-Vis DRS spectra revealed that Fe dopant could effectively reduce the band gap energy and resulted in obvious red shift absorption to the wider visible light region (530–705 nm).
Unsafe fecal disposal practices in children and the nexus with childhood diarrhea in low- and middle-income countries: a systematic review and meta-analysis
Authors: Soboksa Negasa Eshete , Olkeba Beekam Kebede , Negassa Belay , Hareru Habtamu Endashaw , Gudeta Dinkinesh Begna 
Published: November 2022

Abstract
In household environments, the improper handling of children's feces can be a significant contaminant, raising a high risk of child exposure. Thus, the objective of this study was to pool the available evidence on the prevalence of safe child feces disposal practices and their association with reported childhood diarrhea in low-income and middle-income countries. PubMed, Science Direct, Cochrane Library databases, Ovid Medline, Google Scholar, and references of other studies were searched. The search was limited to studies published in English-language literature. Two independent reviewers used an appropriate tool to critically appraise the selected studies. Stata version 16 was used for the analysis. The pooled prevalence of unsafe disposal of children's feces among 20 studies was 52.63% (95% CI: 0.43–0.62). Overall, the meta-analysis found that unsafe disposal practices insignificantly increased the risk of diarrhea by 4% (OR: 1.04, 95% CI: 0.84–1.24). In the subgroup analysis, unsafe disposal of children's feces decreased the risk of diarrhea in Oceania (OR = 0.75, 95% CI = 0.62–0.88) and increased in Asia (OR = 1.33, 95% CI = 1.25–1.41). In conclusion, the prevalence of unsafe child feces disposal practices was high. There was no significant association between unsafe child feces disposal practices and diarrhea.