bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional characterization of NPM1–TYK2 fusion oncogene
Authors: Kuravi Sudhakiranmayi , Baker Riley W. , Mushtaq Muhammad Umair , Saadi Irfan , Lin Tara L. , Vivian Carolyn J. , Valluripalli Anusha , Abhyankar Sunil , Ganguly Siddhartha , Cui Wei , Elenitoba-Johnson Kojo S. J. , Welch Danny R. , Jensen Roy A. , Saunthararajah Yogen , McGuirk Joseph P. , Balusu Ramesh 
Published: January 2022

AbstractGene fusions are known to drive many human cancers. Therefore, the functional characterization of newly discovered fusions is critical to understanding the oncobiology of these tumors and to enable therapeutic development. NPM1–TYK2 is a novel fusion identified in CD30 + lymphoproliferative disorders, and here we present the functional evaluation of this fusion gene as an oncogene. The chimeric protein consists of the amino-terminus of nucleophosmin 1 (NPM1) and the carboxyl-terminus of tyrosine kinase 2 (TYK2), including the kinase domain. Using in vitro lymphoid cell transformation assays and in vivo tumorigenic xenograft models we present direct evidence that the fusion gene is an oncogene. NPM1 fusion partner provides the critical homodimerization needed for the fusion kinase constitutive activation and downstream signaling that are responsible for cell transformation. As a result, our studies identify NPM1–TYK2 as a novel fusion oncogene and suggest that inhibition of fusion homodimerization could be a precision therapeutic approach in cutaneous T-cell lymphoma patients expressing this chimera.
HER3 activation contributes toward the emergence of ALK inhibitor-tolerant cells in ALK-rearranged lung cancer with mesenchymal features
Authors: Tanimura Keiko , Yamada Tadaaki , Okada Koutaroh , Nakai Kunihiro , Horinaka Mano , Katayama Yuki , Morimoto Kenji , Ogura Yuri , Takeda Takayuki , Shiotsu Shinsuke , Ichikawa Kosuke , Watanabe Satoshi , Morimoto Yoshie , Iwasaku Masahiro , Kaneko Yoshiko , Uchino Junji , Taniguchi Hirokazu , Yoneda Kazue , Matoba Satoaki , Sakai Toshiyuki , Uehara Hisanori , Yano Seiji , Kusaba Tetsuro , Katayama Ryohei , Takayama Koichi 
Published: January 2022

AbstractAnaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) have shown dramatic efficacy in patients with ALK-rearranged lung cancer; however, complete response in these patients is rare. Here, we investigated the molecular mechanisms underlying the emergence and maintenance of drug-tolerant cells in ALK-rearranged lung cancer. Cell based-assays demonstrated that HER3 activation and mesenchymal-to-epithelial transition, mediated through ZEB1 proteins, help maintain cell survival and induce the emergence of ALK-TKI-tolerant cells. Compared with ALK-TKIs alone, cotreatment with pan-HER inhibitor afatinib and ALK-TKIs prevented tumor regrowth, leading to the eradication of tumors in ALK-rearranged tumors with mesenchymal features. Moreover, pre-treatment vimentin expression in clinical specimens obtained from patients with ALK-rearranged lung cancer was associated with poor ALK-TKI treatment outcomes. These results demonstrated that HER3 activation plays a pivotal role in the emergence of ALK-TKI-tolerant cells. Furthermore, the inhibition of HER3 signals combined with ALK-TKIs dramatically improves treatment outcomes for ALK-rearranged lung cancer with mesenchymal features.
Climate-induced forest dieback drives compositional changes in insect communities that are more pronounced for rare species
Authors: Sire Lucas , Yáñez Paul Schmidt , Wang Cai , Bézier Annie , Courtial Béatrice , Cours Jérémy , Fontaneto Diego , Larrieu Laurent , Bouget Christophe , Thorn Simon , Müller Jörg , Yu Douglas W. , Monaghan Michael T. , Herniou Elisabeth A. , Lopez-Vaamonde Carlos 
Published: January 2022

AbstractSpecies richness, abundance and biomass of insects have recently undergone marked declines in Europe. We metabarcoded 211 Malaise-trap samples to investigate whether drought-induced forest dieback and subsequent salvage logging had an impact on ca. 3000 species of flying insects in silver fir Pyrenean forests. While forest dieback had no measurable impact on species richness, there were significant changes in community composition that were consistent with those observed during natural forest succession. Importantly, most observed changes were driven by rare species. Variation was explained primarily by canopy openness at the local scale, and the tree-related microhabitat diversity and deadwood amount at landscape scales. The levels of salvage logging in our study did not explain compositional changes. We conclude that forest dieback drives changes in species assemblages that mimic natural forest succession, and markedly increases the risk of catastrophic loss of rare species through homogenization of environmental conditions.
3D magnetic configuration of ferrimagnetic multilayers with competing interactions visualized by soft X-ray vector tomography
Authors: Hermosa-Muñoz Javier , Hierro-Rodríguez Aurelio , Sorrentino Andrea , Martín José I. , Alvarez-Prado Luis M. , Rehbein Stefan , Pereiro Eva , Quirós Carlos , Vélez María , Ferrer Salvador 
Published: January 2022

AbstractFull control of magnetic properties in exchange coupled systems requires a good understanding of 3D magnetic configuration with lateral and in-depth resolution. Here we show results from a soft X-ray tomographic reconstruction which allow determining, solely from the experimental data, a detailed description of the vector magnetic configuration of a ferrimagnetic Gd12Co88/Nd17Co83/Gd24Co76 trilayer with engineered competing anisotropy, exchange and magnetostatic interactions at different depths. The trilayer displays chevron patterns with a distorted closure structure. Near the top Gd24Co76 layer, local exchange springs with out-of-plane magnetization reversal, quasi-domains with ripple-like patterns and magnetic vortices and antivortices across the thickness are observed. The detailed analysis of the magnetic tomogram shows that the effective strength of the exchange spring at the NdCo/GdCo interface can be finely tuned by GdxCo1-x composition and anisotropy (determined by sample fabrication) and in-plane stripe orientation (adjustable), demonstrating the suitability of 3D magnetic visualization techniques in magnetic engineering research.
The global carbon sink potential of terrestrial vegetation can be increased substantially by optimal land management
Authors: Sha Zongyao , Bai Yongfei , Li Ruren , Lan Hai , Zhang Xueliang , Li Jonathon , Liu Xuefeng , Chang Shujuan , Xie Yichun 
Published: January 2022

AbstractExcessive emissions of greenhouse gases — of which carbon dioxide is the most significant component, are regarded as the primary reason for increased concentration of atmospheric carbon dioxide and global warming. Terrestrial vegetation sequesters 112–169 PgC (1PgC = 1015g carbon) each year, which plays a vital role in global carbon recycling. Vegetation carbon sequestration varies under different land management practices. Here we propose an integrated method to assess how much more carbon can be sequestered by vegetation if optimal land management practices get implemented. The proposed method combines remotely sensed time-series of net primary productivity datasets, segmented landscape-vegetation-soil zones, and distance-constrained zonal analysis. We find that the global land vegetation can sequester an extra of 13.74 PgC per year if location-specific optimal land management practices are taken and half of the extra clusters in ~15% of vegetated areas. The finding suggests optimizing land management is a promising way to mitigate climate changes.
Synthesis, structure and aromaticity of metallapyridinium complexes
Authors: Wang Yilun , Sun Yue , Bai Wei , Zhou Yan , Bao Xiao , Li Yang 
Published: January 2022

Rhenapyridinium complexes are synthesized from the reaction of ReCl3(PMePh2)3 with o-ethynyl benzonitriles. These fused metallaaromatics contain both Hückel π-aromatic metallapyridinium rings and σ-aromatic rhenacyclopropene units.
High-temperature dielectric polymer composite films of all-organic PVDF/ABS with excellent energy storage performance and stability
Authors: Zhang Ranran , Li Lili , Long Shaojun , Wang Ping , Wen Fei , Yang Junzhou , Wang Gaofeng 
Published: January 2022

High-temperature dielectric composite films of all-organic PVDF/ABS were fabricated. The composites possessed excellent temperature stability. Ultrahigh Udischarged (11.42 J cm−2) and high efficiency (75.8%) at 100 °C were simultaneously achieved.
Study of hyperchaos resulting from an erbium‐doped fibre three‐ring laser system
Authors: Senlin Yan 
Published: January 2022

AbstractA novel erbium‐doped fibre three‐ring laser system with a ring‐coupled‐ring‐coupled‐ring to obtain dynamic behaviours and develop a theoretical model of a three‐ring laser system is presented. Our studies on the dynamic behaviours of an erbium‐doped fibre three‐ring laser are reported. The fibre laser exhibits hyperchaotic and chaotic behaviours, as well as coexistent scenarios showing routes from period‐doubling to chaos, by shifting the pump levels. The results can be used as a reference value for a chaotic emitter and for chaotic laser technology and applications.
Utility intertie multi‐photovoltaic‐inverters‐based microgrid control for solar rooftop
Authors: Chauhan Shubhra , Singh Bhim 
Published: January 2022

AbstractThe solar photovoltaic (PV)‐based microgrid is one of the most ideal renewable energy resources. This paper presents a utility grid intertie multi‐PV‐inverter‐based microgrid (MG) control for the solar rooftop application. The main and ancillary voltage source converters (VSCs) DC links are assimilated with PV arrays of independent maximum power point tracking (MPPT) algorithms for the economical and efficacious single‐stage configuration. At the point of common coupling (PCC), parallel VSCs arrangement increases the MG's power rating with distinctive local loads. In normal circumstances, the current control methodology is employed by the main VSC under the grid‐interactive mode. Conversely, in some grid contingency conditions under the isolated mode, its control transfers to the voltage control, which regulates the frequency and the voltage at PCC and acts like a grid‐forming inverter. The ancillary VSC operation is implemented with the current control algorithm. The main VSC supplies the active power towards the grid and accomplishes the load requirement, whereas the ancillary VSC retains its load demand in a grid‐interactive mode and also regulates the load requirement in an islanded mode of operation. The utilization of feed‐forward components for PV arrays powers in the VSCs current control techniques improves the MG dynamic performance. The seamless mode transfer performance of the main VSC is implemented via a power electronics switch. The MATLAB software is used to model a microgrid and its performance is analysed via RT‐LAB in real time through the OPAL‐RT (OP4510) controller for various scenarios, that is, varying solar insolation, load alterations and unbalanced non‐linear loads. The utilization of the modified Kwong's algorithm‐based current control enhances the power quality such as harmonics current elimination and improvement in the power factor. The voltage profile of PCC voltages is enhanced via using a modified Kwong's algorithm‐based filter in the voltage controller. The modified Kwong's algorithm has fast convergence, reduces misadjustments and gives very good performance compared to the least‐mean‐square (LMS) and Kwong's approaches. The total harmonic distortion (THD) of grid currents and PCC voltages THD in an isolated mode is found according to the limits of the IEEE‐519 standard.
Managing periprosthetic fractures – a review of the hub and spoke model
Authors: Mudiganty Srikanth , Hughes Luke , Choudry Qaisar , Bokhari Awais 
Published: January 2022

Introduction: Periprosthetic fractures are associated with significant morbidity and mortality. The “hub and spoke model” consists of a central organisation (the hub) and a series of secondary units (the spokes). This study reviews the presentation, management, and outcomes of periprosthetic fractures at a large general district hospital, the Royal Blackburn Hospital. Methods: A retrospective data analysis for patients presenting with periprosthetic fractures from a single general district hospital between January 2011 and December 2020. Details recorded were patient demographics, primary arthroplasty procedure, fracture management, ASA grade, morbidity and mortality, and Unified Classification System for Periprosthetic Fractures (UCSPF). Results: With 229 periprosthetic fractures, the number tripled in 2020 that admitted in 2011. The mean age was 78.6 years (range 33–100), 151 were females. Seventy-five percent of the fractures were managed locally, while 25% a referral to the higher specialist centre was sort. Of the 57 referrals, 50 were transferred to the hub, 5 were operated on locally, and 2 were managed non-operatively. Higher-level care transfer resulted in a delayed definitive treatment (4.8 versus 12 days, p = 0.001). About 94.4% of patients treated locally had a favourable outcome versus 92% of patients treated at the hub hospital. Cumulative mortality rates for the two sites were comparable. Discussion: Most of the patients presenting to the local spoke hospital with periprosthetic fractures were managed in house. For this practice to be preserved, there is a need for future planning, such as maintaining an appropriate skill mix at spoke units. Discussion between specialists at the hub and spoke hospitals reduced patient transfer by 14%.
Diagnostic challenges in patients with alcohol-related liver disease
Authors: Krag Aleksander , Roskams Tania , Pinzani Massimo , Mueller Sebastian 
Published: January 2022

AbstractAlcohol is globally the leading risk factor for cirrhosis and is subsumed under the term alcohol-related liver disease (ALD). However, only ca. 10% of people with harmful alcohol consumption (>40 gram alcohol per day) develop cirrhosis, while 15% have normal liver histology. Unfortunately, laboratory parameters and ultrasound hold little value to neither rule-in nor rule out alcohol related liver fibrosis. While several indices with combinations of liver associated markers such as FIB4 seem to be promising, non-invasive test strategies are urgently needed with cut-off’s that can be applied to guide clinical decision making. The aims of this review article are to highlight novel developments for the diagnosis of ALD and to identify topics of controversy and potential future directions. In the last 15 years, elastography to measure liver stiffness (LS) has significantly improved our screening strategies for cirrhosis. LS values below 6 kPa are considered as normal and exclude ALD. LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. Especially, transient elastography (TE) has been assessed in numerous studies, but similar performance can be obtained with point shear wave elastography, 2 SD shear wave elastography or MR elastography. Important confounders of elevated LS such as inflammation should also be considered and alcohol withdrawal not only improves liver inflammation but also LS. Liver stiffness measurement has signficiantly improved early diagnosis and follow-up of fibrosis in patients with ALD and patients with diagnosed manifest but clinically compensated cirrhosis should undergo further clinical examinations to rule out complications of portal hypertension. In addition, surveillance for the occurrence of hepatocellular carcinoma is recommended in all cirrhotic patients.
Retrieval of a Dislocated Stent Using a Grasping Forceps and a Steerable Sheath in a Fontan Patient
Authors: Kehl Torben , Müller Götz , Rickers Carsten , Kozlik-Feldmann Rainer 
Published: January 2022

AbstractIn Fontan patients, any pulmonary stenosis may impede free passive inflow into the pulmonary circuit and elevate central venous pressure. When stenting such pulmonary stenosis, dislocation of a stent is a feared complication. Here, we report on a successful retrieval of a dislocated Cook Formula stent into the peripheral left pulmonary artery in a Fontan patient with protein-losing enteropathy using a steerable sheath and a grasping forceps. Furthermore, a successful stent implantation for treating the stenosis was possible. Subsequently, we simulated the retraction technique ex vivo. To manage stent dislocation during complex pediatric catheter interventions, we can recommend the use of a steerable sheath guiding a grasping forceps. A dislocated stent can be grasped, completely longitudinally refolded, and safely retrieved.
Recurrent Cardiac Constriction after Implantation of an Expanded Polytetrafluoroethylene Surgical Membrane
Authors: Puiu Paul-Cătălin , Siepe Matthias , Zeh Wolfgang , Zimmer Emmanuel 
Published: January 2022

AbstractOne of the challenges compounding the complexity of reoperative cardiac surgery is the surgical adhesion, which can be responsible for adverse intraoperative events. Implantation of a substitute neo-pericardium has become a frequently used solution, with currently rising numbers of reoperations. We report the case of a 38-year-old man who developed recurrent delayed cardiac constriction following the implantation of an expanded polytetrafluoroethylene neo-pericardium. Careful preoperative planning is recommended to plan the optimal method of pericardioplasty, taking into account the pros and cons of each available material.
Risk Factors and Algorithms for the Empirical Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia
Authors: Pan Di , Niederman Michael S. 
Published: January 2022

AbstractHospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) continue to be major concerns for morbidity and mortality, especially in patients treated in the intensive care unit. With the rise in multidrug-resistant organisms, HAP and VAP treatment is challenged by the need for early appropriate treatment, with broad-spectrum agents, while still being aware of the principles of antibiotic stewardship. The two major society guidelines proposed a series of risk factors in their most recent guidelines to help identify patients who can most benefit from narrow- or broad-spectrum initial empiric antibiotic therapy. The guidelines reveal differences in the proposed risk factors and treatment approaches, as well as major similarities.
Cone-Beam Computed Tomography in Periodontal Diagnosis and Treatment Planning
Authors: Murali Aparna C. , Bhandary Rahul 
Published: January 2022

AbstractDiagnosis of periodontal disease depends on conventional clinical parameters. In periodontitis with extensive bone defects, radiographs play a crucial role in arriving at a proper diagnosis. The emergence of cone-beam computed tomography (CBCT) became a boon in oral radiology. Limitations of conventional two-dimensional (2D) radiographs include inadequate visualization of bone defects, lamina dura, and furcation involvement. CBCT generates 3D images of anatomical structures necessary for the periodontal diagnosis of furcation involvement, intrabony defects, and implant placement. CBCT, thus, imparts various potential applications in the field of periodontics which serves to arrive at better diagnostic conclusions.
Periodontal Manifestations in Vertical Root Fractured Teeth
Authors: Shenoy Nina , Shenoy Arvind 
Published: January 2022

AbstractVertical root fractures are more commonly encountered following endodontic treatment and in teeth without endodontic treatment, with habits like bruxism and eating coarse, hard food. The teeth most predisposed to fracture are the premolars of the maxilla and mandible, the mesial roots and mesiobuccal roots of the mandibular molars, maxillary molars and the mandibular incisors. Timely identification of cracked teeth and fractures is the key since it permits a conservative and preventive approach. Delay in diagnosis and treatment will result in the involvement of the underlying periodontium, causing periodontal pockets, abscess formation, and bone loss, thereby further complicating the outcome. Appropriate diagnosis, education, and counseling of the patient by the dentist and coronal restoration following root canal treatment are mandatory to prevent the loss of teeth in patients. The prognosis of multirooted teeth is more favorable. Affected single-rooted teeth may, however, require immediate extraction. MEDLINE database and Scopus search (www.scopus.com) were performed using the key words “vertical root fracture” or “longitudinal root fracture.” Text book chapters were manually checked.
Detection of ABO Discrepancy in a Case of Coronary Artery Disease by Conventional Tube Technique: A Miss by Column Agglutination Technology
Authors: Routray Suman Sudha , Prakash Satya , Ray Gopal Krushna , Mukherjee Somnath , Sahu Ansuman 
Published: January 2022

AbstractABO and Rh blood grouping of donors and recipients is the first and foremost step in pretransfusion compatibility testing. Conventional tube technique (CTT) is used to test for blood grouping and Rh D typing. But the procedure is cumbersome, and there may be subjective variation during the interpretation of the test results. The other disadvantage is that it is not adaptable to automation. Many newer techniques, such as the column agglutination technique (CAT) used for pretransfusion testing, are amenable to automation. It is being preferred to shift from CTT to semiautomated or fully automated CAT platforms or other newer technologies in many blood centers. The CAT has the added advantage of increased sensitivity and stable end-point results. The results in automated platforms using CAT are equally efficient and reliable as CTT. However, sometimes it is noted that CAT misses subgroups detection. Here, we report a case with a subgroup of A that was failed to be detected by the CAT using dextran acrylamide gel, signifying the use of CTT in evaluating blood group discrepancy.
Finding pathways to synergistic development of Sustainable Development Goals in China
Authors: Zhang Junze , Wang Shuai , Zhao Wenwu , Meadows Michael E. , Fu Bojie 
Published: January 2022

AbstractWhile the Sustainable Development Goal (SDG) index is a widely employed method of measuring progress in the United Nations (UN) SDGs, as it allows comparisons across countries and regions, it does not usually offer any indication as to how to move the SDGs forward. To address this deficit, we analyzed the impact of the offsetting effects of changes in individual SDG scores on the SDG index from 2015 to 2018 at the provincial level in China. Future priority goals are also revealed by accessing the interactions among the SDGs. Our findings show that both the number of SDGs that experienced an increase or decrease in the score and the degree of change in SDG scores have a major impact on changes in the SDG index score. For example, a decline in individual SDG scores at the national level usually represents a decline in the scores of more than 15 provinces, while an increase in the SDG score may mask the fact that some provinces have experienced a decline in their scores. In addition, changes in SDG scores can show some similarities in the strengths and weaknesses even across provinces in different geographical zones. The analysis of SDG interactions suggests that prioritizing the promotion of SDG7 (Affordable and Clean Energy) and SDG12 (Responsible Production and Consumption) will advance the synergistic development of SDGs in China. Overall, our study highlights the necessity to focus not only on regions with declining aggregated index scores but also on goals with declining scores in order to implement the SDGs as a whole. Meanwhile, leveraging the similarity of SDG changes to inform sustainable management policies will contribute to the overall implementation of the SDGs in different regions.