bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal aortic aneurysm and exfoliation syndrome in Utah
Authors: Patil Ayesha , Conley Matthew , Pompoco Christian , Paulson Chase , Taylor Samuel , Swiston Cole , Herrick Jennifer S. , Ritch Robert , Curtin Karen , Wirostko Barbara 
Published: December 2022

AbstractPurposeA pilot study of electronic medical records (EMR) in Utah was undertaken to investigate exfoliation syndrome and exfoliation glaucoma (XFS/XFG) in abdominal aortic aneurysm (AAA) patients. In a subsequent retrospective cohort study of Utah XFS/XFG patients and population controls, the risk of AAA was examined.MethodsEMR of a statewide healthcare population were obtained from the Utah Population Database (UPDB) which links decades of medical records with Utah demographic and vital records data. In a pilot study, 7167 patients ages ≥40 years identified with AAA diagnosed from 1996 to 2015, based on International Classification of Diseases (ICD) version 9/10 codes, were included. A univariable hazards model was used to determine the risk of XFS/XFG in AAA patients. An XFS/XFG outcome based on ICD 9/10 codes in AAA patients and in 5:1 sex‐ and age‐matched non‐AAA controls was determined. A retrospective cohort of 3412 XFS/XFG patients ages ≥50 years diagnosed from 1996 to 2020 and 10 227 3:1 sex‐ and age‐matched controls who underwent ≥1 dilated eye examination(s) were recently identified and updated diagnoses of AAA were obtained. Multivariable logistic regression was used to estimate AAA risk in XFS/XFG patients compared with controls. In a subset of XFS/XFG patients, chart reviews were conducted to confirm clinically diagnosed AAA.ResultsIn the AAA pilot, 20 patients (0.3%) and 118 controls (0.3%) developed XFS/XFG, respectively. We observed no increased risk of XFS/XFG in AAA patients compared with non‐AAA‐matched controls (HR = 0.99, 95% CI 0.6–1.6). Among XFS/XFG study patients and controls, 122 patients (3.6%) and 376 controls (3.7%) had an AAA diagnosis. We likewise observed no increased risk of AAA in XFS/XFG patients (OR = 0.97, 95% CI 0.8–1.2). In 14 XFS/XFG patients with an ICD 9/10 diagnosis of AAA who underwent chart review, a clinical diagnosis of AAA was confirmed in 9 patients (64.3%).ConclusionOur findings do not support an association between AAA and XFS/XFG.
Absence from day care or school and parental absence from work during children's respiratory infections
Authors: Paalanne Marika , Honkila Minna , Paalanne Niko , Mattila Suvi , Pokka Tytti , Renko Marjo , Tapiainen Terhi 
Published: December 2022

AbstractAimTo investigate the social burden of nasopharyngeal detection of various respiratory viruses and the co‐detection of viral and bacterial pathogens.MethodsThis prospective cohort study included 737 children with a suspected respiratory tract infection or fever in a paediatric emergency department during one epidemiological year (2014–2015) in Finland. Nasopharyngeal swab samples were analysed with multiplex polymerase chain reaction for 16 viruses and 7 respiratory bacteria. Parents filled out a questionnaire regarding child's and parents' absence from day care, school, or work at the time of the visit and 14 days afterward.ResultsThe length of the children's absence from day care or school, or parental absence from work, did not significantly differ between the detected viral pathogens. Co‐detection of any respiratory virus and Streptococcus pneumoniae or Haemophilus influenzae in the nasopharynx were associated with a 2.5‐day (95% CI of the difference: 0.71 to 4.3) and 3.0‐day (95% CI: 0.35 to 5.7) longer parental absence from work, respectively, compared with the detection of viruses alone when adjusted for age.ConclusionNasopharyngeal detection of S. pneumoniae or H. influenzae was associated with an increase in the length of parental absence from work when compared with the detection of virus alone.
Environmental impact of single‐use and reusable flexible cystoscopes
Authors: Kemble Jayson P. , Winoker Jared S. , Patel Sunil H. , Su Zhuo T. , Matlaga Brian R. , Potretzke Aaron M. , Koo Kevin 
Published: December 2022

ObjectivesTo compare the carbon footprint and environmental impact of single‐use and reusable flexible cystoscopes.Materials and MethodsWe analysed the expected clinical lifecycle of single‐use (Ambu aScope™ 4 Cysto) and reusable (Olympus CYF‐V2) flexible cystoscopes, from manufacture to disposal. Performance data on cumulative procedures between repairs and before decommissioning were derived from a high‐volume multispecialty practice. We estimated carbon expenditures per‐case using published data on endoscope manufacturing, energy consumption during transportation and reprocessing, and solid waste disposal.ResultsA fleet of 16 reusable cystoscopes in service for up to 135 months averaged 207 cases between repairs and 3920 cases per lifecycle. Based on a manufacturing carbon footprint of 11.49 kg CO2/kg device for reusable flexible endoscopes and 8.54 kg CO2/kg device for single‐use endoscopes, the per‐case manufacturing cost was 1.37 kg CO2 for single‐use devices and 0.0017 kg CO2 for reusable devices. The solid mass of single‐use and reusable devices was 0.16 and 0.57 kg, respectively. For reusable devices, the energy consumption of reusable device reprocessing using an automated endoscope reprocessor was 0.20 kg CO2, and per‐case costs of device repackaging and repair were 0.005 and 0.02 kg CO2, respectively. The total estimated per‐case carbon footprint of single‐use and reusable devices was 2.40 and 0.53 kg CO2, respectively, favouring reusable devices.ConclusionIn this lifecycle analysis, the environmental impact of reusable flexible cystoscopes is markedly less than single‐use cystoscopes. The primary contributor to the per‐case carbon cost of reusable devices is energy consumption of reprocessing.
Sex steroid priming for growth hormone stimulation testing in children and adolescents with short stature: A systematic review
Authors: Duncan Gregor , Kiff Sarah , Mitchell Rod T. 
Published: December 2022

AbstractObjectiveGrowth hormone stimulation testing (GHST) is used to diagnose growth hormone deficiency (GHD) in children. As sex steroids impact on anterior pituitary function, there is concern around the efficacy of GHST in peripubertal children, where endogenous sex steroid levels are low. Sex steroid priming before GHST is thought to improve test efficacy in these children, however evidence to support its use in clinical practice is limited.In this systematic review, we addressed the following research questions: Does priming increase GH stimulation test efficacy in peripubertal children? Does priming identify those who would benefit most from treatment in terms of final height? Is there evidence for an optimal sex‐steroid priming regimen?Design, Patients, MeasurementsThe study was registered with PROSPERO and conducted according to PRISMA guidelines. We searched Medline, Cochrane‐Library, Scopus, EMBASE and Web‐of‐Science and included all studies that included GHST in both primed and unprimed children. A GH cut‐off of 7 µg/L was used as a threshold for GHD. Study quality was assessed using the Risk‐Of‐Bias in Non‐ Randomized Studies (ROBINS‐I) tool or the revised Cochrane risk‐of‐bias tool for Randomised trials.ResultsFifteen studies met our inclusion criteria, of which 4/15 (27%) were randomised control trials. The majority (9/15) of the studies indicated that priming increases growth hormone response upon GHST in peripubertal children, increasing test specificity. Two studies investigated final height after treatment based on the results of primed versus unprimed GHST. These results indicate that growth hormone treatment based on results of a primed GHST improve outcomes compared with treatment based on an unprimed test.ConclusionSex‐steroid priming increases the growth hormone response during GHST, resulting in fewer patients meeting the threshold required for a diagnosis of GHD. Unnecessary GH treatment may be avoided in some patients without a detrimental effect on final height. Numerous sex‐steroid priming regimens have been used in clinical practice and the majority appear to be effective, but an optimal regimen has not been determined.
Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis
Authors: Xie Lv , Zheng Li , Chen Weijie , Zhai Xiaozhu , Guo Yunlu , Zhang Yueman , Li Yan , Yu Weifeng , Lai Zhongmeng , Zhu Ziyu , Li Peiying 
Published: December 2022

AbstractIntroductionPerivascular macrophages (PVMs) play pivotal roles in maintaining the physiological function of the brain. Dysfunction of PVMs is emerging as an important mechanism in various disease conditions in the brain.MethodsIn this work, we analyzed recent research advances in PVMs, especially in the brain, from the Web of Science (WoS) core database using bibliometric analysis based on the search terms “perivascular macrophages” and “perivascular macrophage” on October 27, 2021. Visualization and collaboration analysis were performed by Citespace (5.8 R3 mac).ResultsWe found 2384 articles published between 1997 and 2021 in the field of PVMs, which were selected for analysis. PVMs were involved in several physio‐pathological fields, in which Neurosciences and Neurology, Neuroscience, Immunology, Pathology, and Cardiovascular System and Cardiology were most reported. The research focuses on PVMs mainly in the central nervous system (CNS), inflammation, macrophage or T‐cell, and disease, and highlights the related basic research regarding its activation, oxidative stress, angiotensin II, and insulin resistance. Tumor‐associated macrophage, obesity, myeloid cell, and inflammation were relatively recent highlight keywords that attracted increasing attention in recent years. Harvard Univ, Vrije Univ Amsterdam, occupied important positions in the research field of PVMs. Meanwhile, PVM research in China (Peking Univ, Sun Yat Sen Univ, Shanghai Jiao Tong Univ, and Shandong Univ) is on the rise. Cluster co‐citation analysis revealed that the mechanisms of CNS PVMs and related brain diseases are major specialties associated with PVMs, while PVMs in perivascular adipose tissue and vascular diseases or obesity are another big category of PVMs hotspots.ConclusionIn conclusion, the research on PVMs continues to deepen, and the hotspots are constantly changing. Future studies of PVMs could have multiple disciplines intersecting.
Downregulation of ADAMTS3 Suppresses Stemness and Tumorigenicity in Glioma Stem Cell
Authors: Kim Hyun‐Jin , Jeong Hang Yeon , Batara Don Carlo , Moon Changjong , Lee Seongsoo , Lee Suk Jun , Park Sang‐Ik , Choi Moon‐Chang , Kim Sung‐Hak 
Published: December 2022

AbstractAimsGlioblastoma multiforme (GBM) is the most aggressive type of human brain tumor, with a poor prognosis and a median overall survival of fewer than 15 months. Glioma stem cells (GSCs) have recently been identified as a key player in tumor initiation and therapeutic resistance in GBM. ADAMTS family of metalloproteinases is known to cleave a wide range of extracellular matrix substrates and has been linked to tissue remodeling events in tumor development. Here, we investigate that ADAMTS3 regulates GSC proliferation and self‐renewal activities, and tumorigenesis in orthotopic xenograft models.MethodsADAMTS3 mRNA expression levels in normal human astrocyte (NHA), glioma, and GSCs cell lines were compared. After knockdown of ADAMTS3, alamarBlue assay, in vitro limiting dilution, and orthotopic xenograft assays were performed. To investigate the tumor‐associated roles of ADAMTS3, several statistical assays were conducted using publicly available datasets.ResultsADAMTS3 level was remarkably higher in GSCs than in NHA, glioma cell lines, and their matched differentiated tumor cells. Interestingly, knockdown of ADAMTS3 disrupted GSC's proliferation, self‐renewal activity, and tumor formation in vivo. Furthermore, ADAMTS3 could be used as an independent predictor of malignancy progression in GBM.ConclusionWe identified ADAMTS3 as a potential therapeutic target for GBM.
Involvement of dopamine D2‐like receptors in the antiepileptogenic effects of deep brain stimulation during kindling in rats
Authors: Rezaei Mahmoud , Ghafouri Samireh , Asgari Azam , Barkley Victoria , Fathollahi Yaghoub , Rostami Sareh , Shojaei Amir , Mirnajafi‐Zadeh Javad 
Published: December 2022

AbstractAimsDeep brain electrical stimulation (DBS), as a potential therapy for drug resistive epileptic patients, has inhibitory action on epileptogenesis. In the present investigation, the role of dopamine D2‐like receptors in the antiepileptogenic action of DBS was studied.MethodsSeizures were induced in adult rats by stimulating the perforant path in a semi‐rapid kindling method. Five minutes after the last kindling stimulation, daily DBS was applied to the perforant path at the pattern of low frequency stimulation (LFS; 1 Hz; pulse duration: 0.1 ms; intensity: 50–150 μA; 4 trains of 200 pulses at 5 min intervals). Sulpiride (10 μg/1 μl, i.c.v.), a selective dopamine D2‐like receptor antagonist, was administered prior to the daily LFS application.ResultsKindling stimulations increased cumulative daily behavioral seizure stages, daily afterdischarge duration (dADD), and population spike amplitude (PS) in dentate gyrus following perforant path stimulation, while applying LFS decreased the kindled seizures' parameters. In addition, kindling potentiated the early (at 10–50 ms inter‐pulse interval) and late (at 150–1000 ms inter‐pulse interval) paired‐pulse inhibition and decreased the paired‐pulse facilitation (at 70–100 ms inter‐pulse interval). These effects were also inhibited by applying LFS. All inhibitory effects of LFS on kindling procedure were prevented by sulpiride administration.ConclusionThese data may suggest that LFS exerts its preventive effect on kindling development, at least partly, through the receptors on which sulpiride acts which are mainly dopamine D2‐like (including D2, D3, and D4) receptors.
A call for nail clipping histopathology to become an essential component of the routine evaluation of melanonychia: Benefitting patients as a triage and surgical planning maneuver
Authors: Rodriguez Olaf , Elenitsas Rosalie , Jiang Angela J. , Abbott James , Rubin Adam I. 
Published: December 2022

AbstractWe call on dermatologists and dermatopathologists to include nail clipping histopathology as an essential component of the routine evaluation of melanonychia. This manuscript demonstrates a case where an adult woman with broad melanonychia of the right thumbnail declined a nail matrix biopsy, but was amenable to a nail clipping.The nail clipping showed pigmentation, melanocyte remnants, and small cavities in the nail plate. These features have been published previously by our group as a clue to nail unit melanoma within nail clippings.This patient was rapidly triaged for nail matrix biopsy, which demonstrated nail unit melanoma in situ. Every patient with melanonychia can benefit from a nail clipping by examination of the location of the pigmentation within the nail plate for surgical planning, and if melanocyte remnants are detected, the nail clipping also serves as a rapid triage mechanism for nail matrix biopsy to evaluate for nail unit melanoma. Fontana‐stained sections will highlight the pigmentation in the nail plate, and its location in the nail plate can easily be described by the dermatopathologist. Nail clippings performed in the setting of clinically apparent melanonychia may show helpful histopathologic findings of pigmented fungi, hemorrhage, external pigmentation, features of other pigmented nail unit tumors, as well as other entities. Nail clipping histopathology can provide extensive information in the evaluation of melanonychia with minimal discomfort for a patient, and little disruption to a physician's clinic flow. With this additional case of a nail unit melanoma diagnosed after initial concern found in a nail clipping, as well as other information in the literature, it is clear that melanocyte remnants found in nail clippings are reliable concerning features related to nail unit melanoma in adults. With knowledge of these histopathologic features in nail clippings and the significance of melanocyte remnants, the dermatopathologist can play a crucial role in the use of a nail clipping as a life‐saving diagnostic maneuver. Accordingly, given the potential benefit to patients in this setting, as well as other uses of a nail clipping in the evaluation of melanonychia, we call on dermatologists and dermatopathologists to innovate the routine evaluation of melanonychia through the routine employment of nail clippings for histopathologic evaluation.
Neurotropic melanoma arising from a neurocristic hamartoma
Authors: Clements Stephanie Ann , Kelley Benjamin Franklin , Rivera Louis , Greenway Hubert T. 
Published: December 2022

AbstractNeurotropic melanoma is a rare type of malignant melanoma with nerve invasion or neural differentiation. Neurocristic cutaneous hamartoma is a rare, benign tumor of the skin and superficial soft tissue that arises from aberrant migration of neural crest cells. We report a rare case of a 74‐year‐old man with a clinically diagnosed giant congenital nevus of the right mid‐back, histopathologically confirmed to be a neurocristic cutaneous hamartoma, who developed neurotropic spindle cell melanoma within the lesion. The patient was treated with serial re‐excisions until clear margins were achieved.
Are restrictions in sales hours of alcohol associated with fewer emergency room visits in Lithuania? An interrupted time‐series analysis
Authors: Jiang Huan , Tran Alexander , Petkevičienė Janina , Štelemėkas Mindaugas , Lange Shannon , Rehm Jürgen 
Published: December 2022

AbstractIntroductionOn 1 January 2018, an amendment to the alcohol control law was introduced in Lithuania which, among other changes, reduced trading hours for alcoholic beverages by 4 h for weekdays and Saturdays, and by 9 h for Sundays. The objective of the current study was to quantify the potential association of this law with the numbers and types of emergency room (ER) visits in Lithuania, in general and specifically for Sundays, for all ER visits, for injury‐related ER visits and specifically for alcohol poisoning as a 100% alcohol‐attributable cause.MethodsSex‐stratified time‐series analysis‐based models for the period 2016–2019 were used to test for associations and for potential alternative explanations (e.g., the increase in minimum legal drinking age, which occurred at the same time).ResultsOverall, while the reduction in sales hours for both sexes was associated with slight increases in all types and in injury‐related ER visits on a weekly basis, the association with ER visits for alcohol poisoning was in the opposite direction for men in all models. Specifically, among men, it was associated with an approximate decrease of 20% of alcohol poisoning‐related ER visits on Sundays and an approximate decrease of 12% of alcohol poisoning‐related ER visits for all seven weekdays.Discussion and ConclusionsAs predicted, restrictions on availability were associated with marked reductions in ER visits for alcohol poisoning in men. However, contrary to expectations, there were no overall reductions in overall ER visits, nor reductions in injury‐related ER visits.
The relationship between proficiency‐based instruction and student oral proficiency
Authors: Hancock Charlotte R. , Adams Mary J. , Kissau Scott 
Published: December 2022

AbstractOver past decades, there has been a paradigm shift in WL instruction, moving away from traditional, grammar‐based programs and toward instruction that promotes student proficiency in the target language. Despite this growing attention to proficiency‐based instruction, few studies have investigated the relationship between proficiency‐based programs and student outcomes. Thus, in the present study, the researchers used a mixed methods approach, involving the collection and analysis of assessment and interview data, to investigate the relationship between approach to language teaching and oral proficiency outcomes of high school students enrolled in Level III Spanish, French, and Chinese classrooms. More specifically, the study explored how a proficiency‐based approach enhanced the oral proficiency outcomes of students in comparison to a traditional grammar‐based approach, and how teachers and students perceived the different learning environments. Quantitative data revealed varied oral proficiency development, based on language of study, and that students in the proficiency‐based program had greater oral proficiency than their counterparts who completed the traditional grammar‐based program. Qualitative data suggested that when compared with the grammar‐based program, instruction in the proficiency‐based program was perceived by students to be more relevant and led to more motivated and confident students. Recommendations are provided based upon these critical findings.
Introduction – Droit du travail et segmentation juridique: les différents modèles à l'œuvre dans le monde
Authors: MÜCKENBERGER Ulrich , DINGELDEY Irene 
Published: December 2022

RésuméLe présent numéro spécial vise à alimenter la discussion sur la nécessité de renforcer le cadre de régulation des relations de travail individuelles en proposant une analyse de la segmentation juridique engendrée par les fonctions régulatrice, hiérarchisante et compensatrice du droit du travail. Dans cette introduction, les auteurs présentent les études régionales et thématiques qu'il contient et décrivent leurs propres travaux, menés grâce à une base de données originale, notamment leur méthode, leurs conclusions préliminaires et la typologie des familles de droit à laquelle ils parviennent. L'ensemble du recueil fournit des pistes pour l'élaboration et l'application de règles protégeant tous les travailleurs de la planète.
Neurological complications associated with influenza in hospitalized children
Authors: Jantarabenjakul Watsamon , Paprad Tanitnun , Paprad Tunchanok , Anugulruengkitt Suvaporn , Pancharoen Chitsanu , Puthanakit Thanyawee , Chomtho Krisnachai 
Published: December 2022

AbstractBackgroundInfluenza is a known respiratory and potential neurotropic virus. This study aimed to determine the prevalence and outcomes of influenza‐related neurological complications among hospitalized children.MethodsAll medical records of hospitalized children aged <18 years old diagnosed with influenza at a tertiary care hospital in Bangkok were retrospectively reviewed. Influenza infection was confirmed by rapid antigen or reverse transcription polymerase chain reaction tests. Neurological characteristics and clinical outcomes were analyzed using the Pediatric Cerebral Performance Category Scale.ResultsFrom 2013 to 2018, 397 hospitalized children with a median age of 3.7 years (interquartile range [IQR]: 1.6–6.9) were included. The prevalence of neurological complications, including seizure or acute encephalopathy, was 16.9% (95% confidence interval [CI]: 13.3–20.9). Influenza A and B were identified in 73.1% and 26.9% of the patients, respectively. Among 39 (58.2%) acute symptomatic seizure cases, 25 (37.3%) children had simple febrile seizures, 7 (10.4%) had repetitive seizures, and 7 (10.4%) had provoked seizures with pre‐existing epilepsy. For 28 (41.8%) encephalopathy cases, the clinical courses were benign in 20 (29.9%) cases and severe in 8 (11.9%) cases. Ten (14.9%) children needed intensive care monitoring, and 62 (93.5%) fully recovered to their baselines at hospital discharge. Predisposing factors to the neurological complications included a history of febrile seizure (adjusted odds ratio [aOR]: 20.3; 95% CI: 6.6–63.0), pre‐existing epilepsy (aOR: 3.6; 95% CI: 1.3–10.2), and a history of other neurological disorders (aOR: 3.5; 95% CI: 1.2–10.2).ConclusionsOne fifth of hospitalized children with influenza had neurological complications with a favorable outcome. Children with pre‐existing neurological conditions were at higher risk for developing neurological complications.