bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monotone iterations method for fractional diffusion equations
Authors: Krasnoshchok M. 
Published: June 2022

In recent years, there has been a growing interest on non-localmodels because of their relevance in many practical applications. Awidely studied class of non-local models involves fractional orderoperators. They usually describe anomalous diffusion. Inparticular, these equations provide a more faithful representationof the long-memory and nonlocal dependence of diffusion in fractaland porous media, heat flow in media with memory, dynamics ofprotein in cells etc.
For $a\in (0, 1)$, we investigate the nonautonomous fractionaldiffusion equation:
$D^a_{*,t} u - Au = f(x, t,u),$
where$D^a_{*,t}$ is the Caputo fractional derivative and $A$ is auniformly elliptic operator with smooth coefficients depending onspace and time. We consider these equations together with initialand quasilinear boundary conditions.
The solvability of such problems in H\"older spaces presupposesrigid restrictions on the given initial data. These compatibilityconditions have no physical meaning and, therefore, they can beavoided, if the solution is sought in larger spaces, for instance inweighted H\"older spaces.
We give general existence and uniqueness result andprovide some examples of applications of the main theorem. The maintool is the monotone iterations method. Preliminary we developed thelinear theory with existence and comparison results. The principleuse of the positivity lemma is the construction of a monotonesequences for our problem. Initial iteration may be taken as eitheran upper solution or a lower solution. We provide some examples ofupper and lower solution for the case of linear equations andquasilinear boundary conditions. We notice that this approach canalso be extended to other problems and systems of fractionalequations as soon as we will be able to construct appropriate upperand lower solutions.
Asymptotic estimates for analytic functions in strips and their derivatives
Authors: Beregova G. I. , Fedynyak S. I. , Filevych P. V. 
Published: June 2022

Let $-\infty\le A_0< A\le +\infty$, $\Phi$ be a continuous function on $[a,A)$ such that for every $x\in\mathbb{R}$ we have $x\sigma-\Phi(\sigma)\to-\infty$ as $\sigma\uparrow A$, $\widetilde{\Phi}(x)=\max\{x\sigma -\Phi(\sigma):\sigma\in [a,A)\}$ be the Young-conjugate function of $\Phi$, ${\Phi}_*(x)=\widetilde{\Phi}(x)/x$ for all sufficiently large $x$, and $F$ be an analytic function in the strip $\{s\in\mathbb{C}\colon A_0<\operatorname{Re}s<A\}$ such that the quantity $S(\sigma,F)=\sup\{|F(\sigma+it)|\colon t\in\mathbb{R}\}$ is finite for all $\sigma\in(A_0,A)$ and $F(s)\not\equiv0$. It is proved that if
\smallskip\centerline{$\ln S(\sigma,F)\le(1+o(1)\Phi(\sigma)$ as $\sigma\uparrow A$,}
\smallskip\noi then
\centerline{$\displaystyle\varlimsup_{\sigma\uparrow A}\frac{S(\sigma,F')}{S(\sigma,F){\Phi}_*^{-1}(\sigma)}\le c_0,$}
\smallskip\noiwhere $c_0<1,1276$ is an absolute constant. From previously obtained results it follows that $c_0$ cannot be replaced by a constant less than $1$.
PELAYANAN PENDIDIKAN AGAMA UNTUK ANAK DIFABEL DI SEKOLAH DAN MADRASAH KABUPATEN BONE
Authors: Arsyad Abd. Rahman 
Published: June 2022

<p>Penelitian ini adalah Kualitatif dengan tujuan untuk Mengetahui bagaimana penyelenggaraan pendidikan inklusif dan pelayanan pendidikan agama untuk anak ABK dengan melihat berbagai aspek (Kurikulum, Kesiswaan, Guru, Sapras, Pendanaan dan lingkungan). serta bagaimana faktor pendukung dan penghambat penyelenggaraan pendidikan inklusif pada Madrasah dan Sekolah di Kabupaten Bone.</p><p>Hasil penelitian adalah Pemerintah menyelenggarakan pendidikan inklusif berdasarkan Peraturan Menteri Dinas Pendidikan dan Peraturan Menteri Agama RI. Kemudian lembaga pendidikan (sekolah dan madrasah) mengimplmentasikan atas dasar penunjukkan Dinas Pendidikan dan Kementerian Agama Kabupaten tanpa memberikan penguatan kepada pengelola secara signifikan, ini dibutikan dengan beberapa hal diantaranya: 1). Pihak Sekolah/Madrasah belum dapat mengidentifikasi siswa ABK saat PPDB; 2) Minimnya SDM guru agama terhadap pengetahuan/pemahaman pendidikan inklusi, 3) Belum ada penguatan pendanaan operasional, dan 4) Diperlukan adanya konsistensi para pemangku kebijakan di daerah dalam menindaklanjuti regulasi tersebut.</p><p>Helen Keller International (HKI) hadir di Kabupaten Bone pada tahun 2018 akhir, dengan memberikan dukungan lewat pemberdayaan kepada pemerhati pendidikan agar dapat menyelenggarakan pendidikan serta memberi pelayanan kepada anak yang memiliki keterbatasan.</p>
Evidências científicas sobre a temperatura de aplicação da radiofrequência no fibroedema geloide: revisão de literatura
Authors: Assunção Flávia Fernanda de Oliveira , Tressino Alexia Aparecida Balduino Christoforo , Sartarelli Bianca , Corassari Danila Maria 
Published: June 2022

O Fibroedema Geloide (FEG) é uma afecção vascular e estética, com maior incidência em mulheres, que pode ocasionar a redução da qualidade de vida e autoestima. Sendo a radiofrequência um recurso para seu tratamento, esta revisão buscou por evidências científicas sobre sua aplicação, temperatura ideal para melhores resultados e o nível de evidência dos estudos. Por meio de pesquisa nas bases eletrônicas Pubmed, Lilacs, Web of Science e Cochrane foram limitadas pesquisas entre 2006 e 2019, com os descritores radiofrequency, cellulite, celulite, celulites e a palavra-chave: gynoid lipodystrophy, nos idiomas português e inglês. Foram incluídos estudos que descreveram o objetivo de investigar a radiofrequência de forma isolada no FEG. Foram encontrados 206 estudos e 12 foram incluídos. Foram verificadas limitações quanto a metodologia aplicada no âmbito amostra, metodologia empregada, e/ou a análise de dados e ausência de parâmetros de aplicação. Quanto a temperatura observou-se maior representação entre 40 e 42oC, com níveis de evidência moderados quanto aos estudos. São necessários trabalhos futuros com maior padronização de parâmetros, além de um maior rigor metodológico para melhor investigação da temperatura ideal para o tratamento do FEG.
Effects of Collagen Hydrolysate From Large Hybrid Sturgeon on Mitigating Ultraviolet B-Induced Photodamage
Authors: Chen Bei , Yu Lei , Wu Jingna , Qiao Kun , Cui Lulu , Qu Haidong , Su Yongchang , Cai Shuilin , Liu Zhiyu , Wang Qin 
Published: June 2022

Ultraviolet B (UVB) radiation leads to the excessive accumulation of reactive oxygen species (ROS), which subsequently promote inflammation, degradation of the extracellular matrix, and photoaging in skin. Thus antioxidant activity is particularly important when screening for active substances to prevent or repair photodamage. Marine fish-derived bioactive peptides have become a trend in cosmetics and functional food industries owing to their potential dermatological benefits. In this study, 1-diphenyl- 2-pycryl-hydrazyl (DPPH) scavenging activity was selected to optimize the hydrolysis conditions of sturgeon skin collagen peptides with antioxidant activity. The optimal hydrolysis conditions for sturgeon skin collagen hydrolysate (SSCH) were determined by response surface methodology, which comprised an enzyme dosage of flavorzyme at 6,068.4 U/g, temperature of 35.5°C, pH of 7, and hydrolysis time of 6 h. SSCH showed good radical-scavenging capacities with a DPPH scavenging efficiency of 95%. Then, the effect of low-molecular-weight SSCH fraction (SSCH-L) on UVB irradiation-induced photodamage was evaluated in mouse fibroblast L929 cells and zebrafish. SSCH-L reduced intracellular ROS levels and the malondialdehyde content, thereby alleviating the oxidative damage caused by UVB radiation. Moreover SSCH-L inhibited the mRNA expression of genes encoding the pro-inflammatory cytokines IL-1β, IL-6, TNF-α, and Cox-2. SSCH-L treatment further increased the collagen Ⅰα1 content and had a significant inhibitory effect on matrix metalloproteinase expression. The phosphorylation level of JNK and the expression of c-Jun protein were significantly reduced by SSCH-L. Additionally, SSCH-L increased the tail fin area at 0.125 and 0.25 mg/ml in a zebrafish UVB radiation model, which highlighted the potential of SSCH-L to repair UVB-irradiated zebrafish skin damage. Peptide sequences of SSCH-L were identified by liquid chromatography-tandem mass spectrometry. Based on the 3D-QSAR modeling prediction, six total peptides were selected to test the UVB-protective activity. Among these peptides, DPFRHY showed good UVB-repair activity, ROS-scavenging activity, DNA damage-protective activity and apoptosis inhibition activity. These results suggested that DPFRHY has potential applications as a natural anti-photodamage material in cosmetic and functional food industries.
Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events
Authors: Huang Zhaoliang , Pang Xinghua , Zhong Tingting , Qu Tailong , Chen Na , Ma Shun , He Xinrong , Xia Dennis , Wang Max , Xia Michelle , Li Baiyong 
Published: June 2022

BackgroundIgG4 anbibodies are deficient in stability and may contribute to tumor-associated escape from immune surveillance. We developed an IgG1 backbone anti-programmed cell death protein-1 (PD-1) antibody, penpulimab, which is designed to remove crystallizable fragment (Fc) gamma receptor (FcγR) binding that mediates antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and proinflammatory cytokine release.MethodsAggregation of different anti-PD-1 antibodies was tested by size exclusion chromatography, and melting temperature midpoint (Tm) and aggregation temperature onset (Tagg) were also determined. The affinity constants of penpulimab for PD-1 and human FcγRs were measured by surface plasmon resonance and biolayer interferometry. ADCC and ADCP were determined in cellular assays and antibody-dependent cytokine release (ADCR) from human macrophages was detected by ELISA. Binding kinetics of penpulimab to human PD-1 was determined by Biacore, and epitope/paratope mapping of PD-1/penpulimab was investigated using x-ray crystallography. Additionally, patients from six ongoing trials were included for analysis of immune-related adverse events (irAEs).ResultsPenpulimab demonstrated better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies. As expected, penpulimab exhibited no apparent binding to FcγRIa, FcγRIIa_H131, FcγRIIIa_V158 and FcγRIIIa_F158, elicited no apparent ADCC and ADCP activities, and induced no remarkable IL-6 and IL-8 release by activated macrophages in vitro. Penpulimab was shown in the co-crystal study to bind to human PD-1 N-glycosylation site at N58 and had a slower off-rate from PD-1 versus nivolumab or pembrolizumab. Four hundred sixty-five patients were analyzed for irAEs. Fifteen (3.2%) patients had grade 3 or above irAEs. No death from irAEs was reported.ConclusionsIgG1 backbone anti-PD1 antibody penpulimab has a good stability and reduced host cell protein residue, as well as potent binding to the antigen. Fc engineering has eliminated Fc-mediated effector functions of penpulimab including ADCC, ADCP and reduced ADCR, which may contribute to its more favorable safety profile.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier: AK105-101: NCT03352531, AK105-201: NCT03722147, AK105-301: NCT03866980, AK105-202:NCT03866967, AK105-203: NCT04172571, AK105-204: NCT04172506.
Improvement Effect of Bifidobacterium animalis subsp. lactis MH-02 in Patients Receiving Resection of Colorectal Polyps: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Liu Hui , Zhang Kaige , Liu Peng , Xu Xuan , Zhou Yuyang , Gan Lihong , Yao Ling , Li Bin , Chen Tingtao , Fang Nian 
Published: June 2022

BackgroundPostoperative symptoms, bowel dysfunction and recurrence are common problems after resection of colorectal polyps. We aimed to evaluate the efficacy of Bifidobacterium in the postoperative patients.MethodsIn this single-center, randomized, double-blind, placebo-controlled trial, adults (≥ 18 years) undergoing endoscopic resection of colorectal polyps were treated with probiotics (Bifidobacterium animalis subsp. lactis MH-02, 2 × 109 colony-forming units per packet) or placebo once daily for 7 days. The primary clinical endpoint was a reduction in the mean total postoperative symptoms score within 7 days postoperatively. Secondary clinical endpoints were the single symptom scores, time to recovery of bowel function, and changes in the intestinal microbiota. This study is registered with the number ChiCTR2100046687.ResultsA total of 100 individuals were included (48 in probiotic group and 52 in placebo group). No difference was seen in the mean scores between the two groups (0.29 vs. 0.43, P = 0.246). Colorectal polyps size (P = 0.008) and preoperative symptoms (P = 0.032) were influential factors for the primary endpoint. Besides, MH-02 alleviated difficult defecation (P = 0.045), and reduced the time to recovery of bowel function (P = 0.032). High-throughput analysis showed that MH-02 can help restore the diversity of intestinal microbiota, and increased the relative abundance of Bifidobacterium, Roseburia, Gemmiger, Blautia and Ruminococcus, while reduced the relative abundance of Clostridium at genus level (P &lt; 0.05).ConclusionIn this prospective trial, MH-02 showed efficacy in patients with resection of colorectal polyps, particularly in the recovery of bowel function, and the changes in the intestinal microbiota may provide evidence for further exploration of the therapeutic mechanisms.
Adsorptive Removal of Atrazine From Contaminated Water Using Low-Cost Carbonaceous Materials: A Review
Authors: Ahmad Munir , Riaz Umair , Iqbal Shazia , Ahmad Jahangir , Rasheed Hina , Al-Farraj Abdullah S. F. , Al-Wabel Mohammad I. 
Published: June 2022

Extensive utilization of atrazine (estimated consumption of 70,000–90,000 tons per annum globally) to eliminate undesirable weeds has resulted in the accumulation of atrazine and its metabolites (diaminochlorotriazine, deisopropylatrazine, desethylatrazine, and atrazine mercapturate) in surface and groundwater above maximum permissible limits (drinking water: 3 μg L−1in the United States, 0.1 μg L−1in Europe, and 3.0 μg L−1by the WHO). Atrazine exhibited no to low degradation in aquatic environments; however, poor degradation in soil yields toxic metabolites, which serve as sinks for groundwater resources. Due to mobility, atrazine and its metabolites can persist in various environmental matrices for decades without degradation, posing a serious threat to ecosystem sustainability and, thus, being removed from water resources. Majority of conventional wastewater treatment technologies are either expensive or inefficient. The carbonaceous materials such as activated carbon, biochar, carbon nanotubes, and graphene have been employed as potent adsorbents for the efficient removal of atrazine along with its metabolites from wastewater. Thus, the efficacy of the aforementioned carbonaceous adsorbents for atrazine removal has been discussed in this article by reviewing 161 published articles. The literature survey demonstrated the highest atrazine adsorption capacity of activated carbons (13.95–712.10 mg g−1), followed by biochar (4.55–409.84 mg g−1) and carbon nanotubes (28.21–110.80 mg g−1). Atrazine adsorption onto the carbonaceous adsorbents is a complex process involving single or multiple mechanisms, such as hydrogen bonding, electrostatic interactions, van der Waals forces, hydrophobic interactions, π-π electron donor–acceptor interactions, pore filling, and partitioning. It is recommended that monitoring of atrazine and its metabolites in water resources and their impacts on human and animal lives be explored. Furthermore, modification of carbon-based adsorbents with chemical, mechanical, and thermal means, as well as development of hybrid systems, may completely remove the prevailing atrazine and its metabolites from world water resources.
Case Report: SMART ANTON: Anton-Babinski Syndrome in Stroke-Like Migraine Attacks (SMART) After Radiation Therapy: Two Rare Syndromes, One Case
Authors: Nagysomkuti Mertse Nicolas , Müri René 
Published: June 2022

IntroductionWe describe the case of a 57-years-old patient who presented an Anton-Babinski syndrome in the context of a stroke-like migraine attack after radiation therapy (SMART).Case ReportThe patient was brought to the emergency room following a sudden loss of vision in the context of a pre-existing left-sided hemianopia after excision of a right occipital astrocytoma followed by radio-chemotherapy 35 years prior to his admission in our services. At admittance, he also presented hyperthermia, hypertension, and a GCS of 7. The MRI showed a leptomeningeal enhancement in the left temporal, parietal, and occipital lobes. After exclusion of other differential diagnoses, we diagnosed a cortical blindness in the context of a SMART syndrome affecting the left hemisphere. While the symptoms improved under corticosteroid therapy, the patient successively presented an Anton-Babinski syndrome, a Riddoch syndrome and a visual associative agnosia before finally regaining his usual sight.DiscussionThis is, to our knowledge, the first report of an Anton-Babinski syndrome in the context of a SMART syndrome. A dual etiology is mandatory for cortical blindness in SMART syndrome since the latter affects only one hemisphere. A SMART syndrome affecting the contralateral hemisphere in respect to the radiation site seems to be uncommon, which makes this case even more exceptional.
Morphological Changes of Frontal Areas in Male Individuals With HIV: A Deformation-Based Morphometry Analysis
Authors: Chen Guochao , Cai Dan-Chao , Song Fengxiang , Zhan Yi , Wei Lei , Shi Chunzi , Wang He , Shi Yuxin 
Published: June 2022

ObjectivePrevious studies on HIV-infected (HIV+) individuals have revealed brain structural alterations underlying HIV-associated neurocognitive disorders. Most studies have adopted the widely used voxel-based morphological analysis of T1-weighted images or tracked-based analysis of diffusion tensor images. In this study, we investigated the HIV-related morphological changes using the deformation-based morphometry (DBM) analysis of T1-weighted images, which is another useful tool with high regional sensitivity.Materials and MethodsA total of 157 HIV+ (34.7 ± 8.5 years old) and 110 age-matched HIV-uninfected (HIV-) (33.7 ± 10.1 years old) men were recruited. All participants underwent neurocognitive assessments and brain scans, including high-resolution structural imaging and resting-state functional imaging. Structural alterations in HIV+ individuals were analyzed using DBM. Functional brain networks connected to the deformed regions were further investigated in a seed-based connectivity analysis. The correlations between imaging and cognitive or clinical measures were examined.ResultsThe DBM analysis revealed decreased values (i.e., tissue atrophy) in the bilateral frontal regions in the HIV+ group, including bilateral superior frontal gyrus, left middle frontal gyrus, and their neighboring white matter tract, superior corona radiata. The functional connectivity between the right superior frontal gyrus and the right inferior temporal region was enhanced in the HIV+ group, the connectivity strength of which was significantly correlated with the global deficit scores (r = 0.214, P = 0.034), and deficits in learning (r = 0.246, P = 0.014) and recall (r = 0.218, P = 0.031). Increased DBM indexes (i.e., tissue enlargement) of the right cerebellum were also observed in the HIV+ group.ConclusionThe current study revealed both gray and white matter volume changes in frontal regions and cerebellum in HIV+ individuals using DBM, complementing previous voxel-based morphological studies. Structural alterations were not limited to the local regions but were accompanied by disrupted functional connectivity between them and other relevant regions. Disruptions in neural networks were associated with cognitive performance, which may be related to HIV-associated neurocognitive disorders.
Association Between Sugar-Sweetened Beverage Consumption and Executive Function Among Chinese Tibetan Adolescents at High Altitude
Authors: Zhang Feng , Yin Xiaojian , Liu Yuan , Li Ming , Gui Xiaoying , Bi Cunjian 
Published: June 2022

ObjectiveTo estimate the association between sugar-sweetened beverage (SSB) consumption and executive function (EF) among Chinese Tibetan adolescents.MethodUsing three stages by stratified cluster sampling, 1,427 Chinese Tibetan adolescents were recruited from Tibet, China. SSB consumption status was obtained by questionnaires and the three core EFs (inhibition, working memory, and cognitive flexibility) were tested by a modified Eriksen flanker task, N-back shift, and a more-odd shifting task. One-way ANOVA or Chi-square test was used to compare SSB consumption in different categories. Taking the SSB consumption 0 time/week group as the reference, general linear regression (for continuous variable) or Logical regression (classified variable) in three Models was conducted to analyze the relationship between SSB consumption and EF for Chinese Tibetan children and adolescents.ResultAfter adjustment of all the covariant in Model 2, all the EF indexes were higher in Chinese Tibetan adolescents with SSB consumption ≥2 times/week than that with SSB consumption of 0 times/week by 21.33 ms (95%CI: 6.72, 35.93), 8.21 ms (95%CI: 7.06, 9.35), 90.46 ms (95%CI: 28.69, 152.23), 147.61 ms (95%CI: 81.42, 213.80), 116.18 ms (95%CI: 74.48, 157.87), 112.41 ms (95%CI: 71.30, 153.52) for incongruent RT, RT difference in incongruent and congruent, 1-back RT, 2-back RT, Heterogeneous RT, RT difference in Heterogeneous and Homogeneous respectively.ConclusionsThe results suggested that SSB consumption was associated with poorer EF in Chinese Tibetan adolescents. SSB consumption should be controlled for healthy brain development of Chinese Tibetan adolescents.
Effects of Cell Phone Dependence on Mental Health Among College Students During the Pandemic of COVID-19: A Cross-Sectional Survey of a Medical University in Shanghai
Authors: Xu Ting , Sun Xiaoting , Jiang Ping , Chen Minjie , Yue Yan , Dong Enhong 
Published: June 2022

ObjectiveTo investigate the effects of cell phone dependence (CPD) on mental health among undergraduates during the COVID-19 pandemic and further identify the determinants that may affect their mental health in China.MethodsThe data were collected from 602 students at a medical school in Shanghai via an online survey conducted from December 2021 to February 2022. The Mobile Phone Addiction Index (MPAI) and Depression Anxiety Stress Scale (DASS) were applied to evaluate CPD and mental health, respectively. Independent sample t-test and one-way analysis of variance (ANOVA) were employed to compare the means of continuous variables among categorical groups. Correlations between continuous variables were detected using Pearson's correlation analysis. Univariable and multivariable logistic regressions were employed to identify the determinants of mental health.ResultsAmong the 402 eligible students, 73.88% were women with an average age of 20.19 ± 2.36 years. On average, the DASS score was 32.20 ± 11.07, the CPD score was 36.23 ± 11.89, and the cell phone use duration was 7.67 ± 3.61 h/day. CPD was found to have a negative effect on mental health among college students in Shanghai. Additionally, cell phone use duration, age, being senior students, faculty-student relationship, insomnia, tobacco use, obesity, and life satisfaction were clarified as contributing factors to mental health among college students.ConclusionHigh degree of CPD could have a negative effect on college students' mental health, which might lead to some psychological problems. Appropriate actions and effective interventions are highly needed to prevent severe psychological injuries among college students in China.