bluuebunny/crossref_metadata_2025_split huggingface dataset:
Configurational path of successful entrepreneurship based on open government data: a QCA analysis
Authors: Zhang Han , Kang Fei , Li Huiying 
Published: September 2022

PurposeIn the era of big data, data have become an essential factor of production. In the context of open government data (OGD), encouraging the commercial development of OGD is significant for promoting mass innovation and entrepreneurship. This study aims to explore the configurational impact of data supply, external environment and entrepreneurial foundation on data-driven entrepreneurship.Design/methodology/approachThis research used a fuzzy set qualitative comparative analysis (fsQCA). Fourteen start-ups using OGD were taken as a case sample.FindingsThis study produces two paths to achieving high entrepreneurial performance, one is a financing-enhanced entrepreneurial path and the other is a data-driven entrepreneurial path. Besides, four conditions are necessary for high performance of OGD-based entrepreneurship: good data quality, mature legal environment, favorable market environment and abundant big data entrepreneurial talents.Practical implicationsThe findings have important practical implications for formulating policies related to promoting the application of government open data and innovation and entrepreneurship in terms of strengthening top-level design, improving the legal environment, developing the data market and cultivating entrepreneurial talents.Originality/valueAlthough many studies have been conducted on OGD, studies on the paths to successful entrepreneurship based on OGD are limited. In this study, this issue is investigated from a configurational perspective by using the fsQCA technique.
A gain of function ryanodine receptor 2 mutation (R1760W‐RyR2) in catecholaminergic polymorphic ventricular tachycardia
Authors: Li Siyuan , Lv Tingting , Yang Jing , Li Kun , Yang Ying , Zhang Ping 
Published: September 2022

AbstractCatecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome associated with Ca2+ leak predominantly caused by ryanodine receptor 2 (RyR2) mutations. We identified a R1760W‐RyR2 mutation located between the N‐terminal domain and the central domain of RyR2 in a CPVT patient by DNA sequencing. Recombinant mutant RyR2−2801mcherry plasmid generated by the overlap extension polymerase chain reaction and seamless cloning was transfected in HEK293 cells for the cell model. Single‐cell luminal and cytosolic Ca2+ imaging was measured by endoplasmic reticulum (ER) luminal Ca2+‐sensitive protein D1ER and Fura‐2 AM on a confocal laser scanning microscope, respectively. We found that in RyR2 mutant cells, the propensity for store‐overload‐induced Ca2+ release (SOICR) was enhanced representing increased Ca2+ oscillations, reduced activation and termination thresholds of spontaneous Ca2+ release; and the sensitivity to cytosolic Ca2+ activation was increased manifesting reduced steady state ER Ca2+ levels. Our results indicated that R1760W‐RyR2 mutation induced calcium leak, representing a gain of function. Further, antiarrhythmic drugs propafenone and flecainide significantly suppressed SOICR caused by the R1760W‐RyR2 mutation at a concentration of 20 μM, which was lower than the concentration at which carvedilol suppressed SOICR.
Rural primary care workforce views on trauma‐informed care for parents experiencing complex trauma: A descriptive study
Authors: Reid Carol , Bennetts Shannon K. , Nicholson Jan M. , Amir Lisa H. , Chamberlain Catherine 
Published: September 2022

AbstractBackgroundAn important service system for rural parents experiencing complex trauma is primary health care.AimTo investigate workforce knowledge, attitudes and practices, and barriers and enablers to trauma‐informed care in rural primary health care.Material & MethodsThis study used a descriptive, cross‐sectional design. It involved an on‐line survey conducted in 2021 in rural Victoria, Australia. Participants were the primary health care workforce. The main outcome measures were study‐developed and included, a 21‐item Knowledge, Attitudes and Practices tool, a 16‐item Barriers and Enablers to Trauma‐Informed Care Implementation tool, and three open‐ended questions.ResultsThe 63 respondents were from community health (n = 40, 63%) and child and family services (n = 23, 37%). Many (n = 43, 78%) reported undertaking trauma‐informed care training at some point in their career; with 32% (n = 20) during higher education. Respondents self‐rated their knowledge, attitudes and practices positively. Perceived enablers were mainly positioned within the service (e.g. workforce motivation and organisational supports) and perceived barriers were largely external structural factors (e.g. availability of universal referral pathways, therapeutic‐specific services). Open‐ended comments were grouped into four themes: (1) Recognition and understanding; (2) Access factors; (3) Multidisciplinary and collaborative approaches; and (4) Strengths‐based and outcome‐focused approaches.Discussion & ConclusionPrimary health care is an important driver of population health and well‐being and critical in rural contexts. Our findings suggest this sector needs a rural trauma‐informed care implementation strategy to address structural barriers. This also requires policy and system development. Long‐term investment in the rural workforce and primary care service settings is essential to integrate trauma‐informed care.
Impact of COVID‐19 on the management and outcomes of ureteric stones in the UK: a multicentre retrospective study
Authors: Byrne Matthew H.V. , Georgiades Fanourios , Light Alexander , Lovegrove Catherine E. , Dominic Catherine , Rahman Josephine , Kathiravelupillai Senthooran , Klatte Tobias , Saeb‐Parsy Kasra , Kumar Rajeev , Howles Sarah , Stewart Grant D. , Turney Ben , Wiseman Oliver ,   the COVID Stones Collaborative
Published: September 2022

ObjectivesTo determine if management of ureteric stones in the UK changed during the coronavirus disease 2019 (COVID‐19) pandemic and whether this affected patient outcomes.Patients and methodsWe conducted a multicentre retrospective study of adults with computed tomography‐confirmed ureteric stone disease at 39 UK hospitals during a pre‐pandemic period (23/3/2019–22/6/2019) and a period during the pandemic (the 3‐month period after the first severe acute respiratory syndrome coronavirus‐2 case at individual sites). The primary outcome was success of primary treatment modality, defined as no further treatment required for the index ureteric stone. Our study protocol was published prior to data collection.ResultsA total of 3735 patients were included (pre‐pandemic 1956 patients; pandemic 1779 patients). Stone size was similar between groups (P > 0.05). During the pandemic, patients had lower hospital admission rates (pre‐pandemic 54.0% vs pandemic 46.5%, P < 0.001), shorter mean length of stay (4.1 vs 3.3 days, P = 0.02), and higher rates of use of medical expulsive therapy (17.4% vs 25.4%, P < 0.001). In patients who received interventional management (pre‐pandemic 787 vs pandemic 685), rates of extracorporeal shockwave lithotripsy (22.7% vs 34.1%, P < 0.001) and nephrostomy were higher (7.1% vs 10.5%, P = 0.03); and rates of ureteroscopy (57.2% vs 47.5%, P < 0.001), stent insertion (68.4% vs 54.6%, P < 0.001), and general anaesthetic (92.2% vs 76.2%, P < 0.001) were lower. There was no difference in success of primary treatment modality between patient cohorts (pre‐pandemic 73.8% vs pandemic 76.1%, P = 0.11), nor when patients were stratified by treatment modality or stone size. Rates of operative complications, 30‐day mortality, and re‐admission and renal function at 6 months did not differ between the data collection periods.ConclusionsDuring the COVID‐19 pandemic, there were lower admission rates and fewer invasive procedures performed. Despite this, there were no differences in treatment success or outcomes. Our findings indicate that clinicians can safely adopt management strategies developed during the pandemic to treat more patients conservatively and in the community.
Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor
Authors: Arias Hugo R. , Germann Allison L. , Pierce Spencer R. , Sakamoto Seiji , Ortells Marcelo O. , Hamachi Itaru , Akk Gustav 
Published: September 2022

Background and PurposePositive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7‐PAMs) possess promnesic and procognitive properties and have potential in the treatment of cognitive and psychiatric disorders including Alzheimer's disease and schizophrenia. Behavioural studies in rodents have indicated that α7‐PAMs can also produce antinociceptive and anxiolytic effects that may be associated with positive modulation of the GABAA receptor. The overall goal of this study was to investigate the modulatory actions of selected α7‐PAMs on the GABAA receptor.Experimental ApproachWe employed a combination of cell fluorescence imaging, electrophysiology, functional competition and site‐directed mutagenesis to investigate the functional and structural mechanisms of modulation of the GABAA receptor by three representative α7‐PAMs.Key ResultsWe show that the α7‐PAMs at micromolar concentrations enhance the apparent affinity of the GABAA receptor for the transmitter and potentiate current responses from the receptor. The compounds were equi‐effective at binary αβ and ternary αβγ GABAA receptors. Functional competition and site‐directed mutagenesis indicate that the α7‐PAMs bind to the classic anaesthetic binding sites in the transmembrane region in the intersubunit interfaces, which results in stabilization of the active state of the receptor.Conclusion and ImplicationsWe conclude that the tested α7‐PAMs are micromolar‐affinity, intermediate‐ to low‐efficacy allosteric potentiators of the mammalian αβγ GABAA receptor. Given the similarities in the in vitro sensitivities of the α7 nACh and α1β2γ2L GABAA receptors to α7‐PAMs, we propose that doses used to produce nACh receptor‐mediated behavioural effects in vivo are likely to modulate GABAA receptor function.
Real‐world usage of sulphonylureas in Asian patients with type 2 diabetes using the Joint Asia Diabetes Evaluation (JADE) register
Authors: Lim Lee‐Ling , Lau Eric S. H. , Cheung Johnny T. K. , Chan Siew Pheng , Ji Linong , Lim Soo , Sirinvaravong Sirinart , Unnikrishnan A. G. , Luk Andrea O. Y. , Cortese Viviana , Durocher Alexandra , Chan Juliana C. N. 
Published: September 2022

AbstractAimsTo explore the patterns of use of oral glucose‐lowering drugs (OGLDs) in Asian patients with type 2 diabetes (T2D), focusing on sulphonylureas (SUs), and to describe patient profiles according to treatment regimen.MethodsWe conducted a cross‐sectional analysis of data from adults with T2D from 11 Asian countries/regions with structured assessment enrolled in the prospective Joint Asia Diabetes Evaluation (JADE) register between November 2007 and December 2019. Patients receiving insulin and/or injectable glucagon‐like peptide‐1 receptor agonists were excluded.ResultsAmongst 62 512 patients (mean ± standard deviation age: 57.3 ± 11.8 years; 53.6% men), 54 783 (87.6%) were treated with OGLDs at enrolment. Most received one (37.5%) or two (44.2%) OGLDs. In the entire cohort, 59.4% of treated patients received SU‐based therapy with variations amongst countries/regions. Overall, 79.5% of SU regimens were based on SUs plus metformin, and 22.1% on SUs plus dipeptidyl peptidase‐4 inhibitors. Among SU users, gliclazide was most commonly prescribed (46.7%), followed by glimepiride (40.0%) and glibenclamide (8.1%). More gliclazide users entered the cohort with glycated haemoglobin levels <53 mmol/mol (7%) than non‐gliclazide SU users (odds ratio [OR] 1.09, 95% CI 1.02‐1.17), with less frequent self‐reported hypoglycaemia in the 3 months before registration (OR 0.81, 95% CI 0.72‐0.92; adjusted for sociodemographic factors, cardiometabolic risk factors, complications, use of other OGLDs, country/region and year of registration).ConclusionIn Asia, SUs are a popular OGLD class, often combined with metformin. Good glycaemic control and safety profiles associated with the use of SUs, including gliclazide, support their position as a key treatment option in patients with T2D.
Salmon of the Southeastern U.S.: Sucker migrations deliver resource subsidies to oligotrophic stream
Authors: White Mack , Wheeler Kit , Hudson Ryan R. , Murdock Justin N. 
Published: September 2022

AbstractThe ability for migratory fishes to move commonly limiting resources such as nitrogen (N) and phosphorus (P) between discrete environments can have pronounced effects on recipient ecosystems. To further understand the geographic and taxonomic scope of migratory fish resource subsidies, we quantified N and P subsidies delivered by adfluvial suckers (Smallmouth Buffalo,Ictiobus bubalus) via excretion, eggs and carcasses to a small oligotrophic stream during their annual spawning migration. We also compared nutrient inputs from migrant buffalo with watershed nutrient export to assess the likelihood that delivered nutrients were ecologically important. We estimated that approximately 67,000 buffalo delivered 730 kg of N and 80 kg of P to Citico Creek as a result of excretion and egg subsidies across three migration waves. We estimated that carcasses delivered negligible amounts of N and P due to extremely low retention. The ratio of migrant inputs (Mw) to system export (Ew;Mw/Ew) varied amongst three migration waves and compounds (i.e. dissolved inorganic nitrogen, ammonium and soluble reactive phosphorus), with values forMw/Ewranging from 0.25 to 5.10, reflecting the potential of nutrient subsidies to exceed nutrients exported from the system under certain conditions. Our findings suggest that suckers have the potential to deliver large resource subsidies to their spawning habitats and that these subsidies may be ecologically important, thus warranting additional consideration of the functional relevance of nongame fishes and their migrations.
Analysis of cutaneous bacterial microbiota of Thai patients with seborrheic dermatitis
Authors: Dityen Kanthaporn , Soonthornchai Wipasiri , Kueanjinda Patipark , Kullapanich Chitrasak , Tunsakul Naruemon , Somboonna Naraporn , Wongpiyabovorn Jongkonnee 
Published: September 2022

AbstractSeborrheic dermatitis (SD) is a chronic inflammatory skin condition that occurs in body areas that contain profuse sebaceous glands. Skin microbiota are diverse across ethnic groups and its dysbiosis has been implicated in the pathogenesis of SD. Here, we reported the contribution of cutaneous bacterial microbiota to SD in the Thai population. Healthy individuals and patients with scalp SD were recruited into the study. Normal skin, scalp skin lesion (SL) and non‐lesion sites (SNL) samples were collected using a tape stripping method and next‐generation sequencing of 16S rRNA for microbiome analysis. Although bacterial diversity in all sample groups was not statistically different, a population of bacteria commonly found on skin of scalp showed signs of dysbiosis. Apart from the reduction of Corynebacterium spp., SD‐specific microbiota was dominated by Firmicutes at taxa level and Pseudomonas spp., Staphylococcus spp. and Micrococcus spp. at genus level. The dysbiosis of the skin microbiota in SD was specifically described as an alteration of bacteria populations commonly found on scalp skin, implying that managing and controlling the cutaneous bacterial microbiome can alleviate and prevent SD and pave the way for the development of new SD treatments.
A, B, C, 1, 2, 3: How an amendment to the New York State education law will give private school students an equitable education to public school students
Authors: Guariglia Elizabeth M. 
Published: September 2022

AbstractIn 2018, in his lawsuit against Governor Andrew Como, Naftuli Moster alerted the world to the inequality between public and private education in New York State. This Note proposes amending the Felder Amendment to ensure that private school students in New York State are given a “substantially equivalent” education to those students in public schools. By making the Felder Amendment more specific in the guidelines it uses to assess the quality of the private schools, New York State can ensure that all children are being given an equitable education.
Is it time for popcorn? Daily box office earnings and aggregate stock returns
Authors: Oz Seda , Fortin Steve 
Published: September 2022

AbstractWe quantitatively measure the interactions between daily consumption and the stock market. We find that daily consumption, proxied by the cyclical component of theatrical box office earnings, can significantly and positively predict stock returns for up to 5 days. We also demonstrate a trading strategy using our consumption measures that yield nontrivial excess returns with little risk. These findings suggest that the box office effect is an economically important factor for equities. The framework implies that daily consumption carries value‐relevant public information, which leads to price reaction at a daily frequency.
Physiological and metabolic responses of chemolithoautotrophic NO3− reducers to high hydrostatic pressure
Authors: Pérez‐Rodríguez Ileana , Sievert Stefan M. , Fogel Marilyn L. , Foustoukos Dionysis I. 
Published: September 2022

AbstractWe investigated the impact of pressure on thermophilic, chemolithoautotrophic reducing bacteria of the phyla Campylobacterota and Aquificota isolated from deep‐sea hydrothermal vents. Batch incubations at 5 and 20 MPa resulted in decreased consumption, lower cell concentrations, and overall slower growth in Caminibacter mediatlanticus (Campylobacterota) and Thermovibrio ammonificans (Aquificota), relative to batch incubations near standard pressure (0.2 MPa) conditions. Nitrogen isotope fractionation effects from chemolithoautotrophic reduction by both microorganisms were, on the contrary, maintained under all pressure conditions. Comparable chemolithoautotrophic reducing activities between previously reported natural hydrothermal vent fluid microbial communities dominated by Campylobacterota at 25 MPa and Campylobacterota laboratory isolates at 0.2 MPa, suggest robust similarities in cell‐specific reduction rates and doubling times between microbial populations and communities growing maximally under similar temperature conditions. Physiological and metabolic comparisons of our results with other studies of pressure effects on anaerobic chemolithoautotrophic processes (i.e., microbial S0‐oxidation coupled to Fe(III) reduction and hydrogenotrophic methanogenesis) suggest that anaerobic chemolithoautotrophs relying on oxidation–reduction (redox) reactions that yield higher Gibbs energies experience larger shifts in cell‐specific respiration rates and doubling times at increased pressures. Overall, our results advance understanding of the role of pressure, its relationship with temperature and redox conditions, and their effects on seafloor chemolithoautotrophic reduction and other anaerobic chemolithoautotrophic processes.
Iron status among HIV‐infected adults during the first year of antiretroviral therapy in Tanzania
Authors: Abioye Ajibola Ibraheem , Sudfeld Christopher R. , Hughes Michael D. , Aboud Said , Muhihi Alfa , Ulenga Nzovu , Nagu Tumaini J. , Wang Molin , Mugusi Ferdinand , Fawzi Wafaie W. 
Published: September 2022

AbstractBackgroundThe influence of inflammation on iron status among people living with HIV (PLWHIV) has not been well explored. We evaluated the trajectory of iron status among PLWHIV during the first year of highly active antiretroviral therapy (HAART), compared alternative approaches for inflammation correction, and assessed the associations of iron status with HIV‐1 viral load and anthropometric outcomes.MethodsWe conducted a secondary analysis of data from a randomized trial among 400 adults initiating HAART in Tanzania. Ferritin and C‐reactive protein (CRP) were measured at baseline, 1, 6 or 12 months. Ferritin was considered in four ways: unadjusted, and adjusted for inflammation using higher cut‐off (HC), Thurnham‐corrected (TC) and regression‐corrected (RC) approaches. For unadjusted, TC and RC ferritin, iron deficiency (ID) was defined using ferritin < 15 μg/L and elevated iron status was defined using ferritin > 150 μg/L among females and > 200 μg/L among males. For HC ferritin, elevated iron status was defined based on serum ferritin > 500 μg/L, while ID was defined using ferritin < 70 μg/L in the presence of inflammation and < 15 μg/L in the absence of inflammation. Regression models evaluated the trajectory of ferritin concentration across categories of baseline characteristics, and assessed the association of iron status with viral and anthropometric outcomes.ResultsThe prevalence of iron deficiency at HAART initiation was 9% for unadjusted, 17% for HC, 12% for TC and 22% for RC ferritin. The prevalence of elevated iron status was 42% for unadjusted, 18% for HC, 31% for TC, and 15% for RC ferritin. The prevalence of iron deficiency for all three methods increased during the first year of HAART, while the prevalence of elevated iron status decreased. Baseline elevated iron status defined using HC ferritin was associated with a greater risk of HIV‐1 viral load > 1000 copies/mL [relative risk (RR) = 4.29, 95% CI: 1.38–13.3] and incidence of being underweight [body mass index (BMI) < 18.5 kg/m2, hazard ratio (HR) = 3.65, 95% confidence interval (CI): 1.38–9.67]. Neither baseline‐elevated iron status defined using TC or RC ferritin nor baseline iron deficiency defined using any of the three methods was associated with HIV‐1 viral load or anthropometric outcomes.ConclusionsWhether and how inflammation correction is done influences findings of studies of iron status among PLWHIV.
Perspectives of topical formulations for melasma
Authors: de Freitas Andréa Carolina Pinheiro , Rigon Roberta Balansin , Bagatin Ediléia , Leonardi Gislaine Ricci 
Published: September 2022

AbstractMelasma is acquired hyperpigmentation that mainly affects the face, can cause negative changes in self‐esteem, and mostly affects women. Treatment is difficult, and different drugs can be used in mono or combination therapy. In this article, we present a brief overview of melasma, how to evaluate it, and a synthesis of the most commonly used topical therapies and their indications, including sunscreens, pharmacological agents, and plant extracts. Hydroquinone (4%) in monotherapy or combined with corticosteroids (dexamethasone and fluocinolone acetonide) and retinoids (tretinoin); arbutin (1%); methimazole (5%); kojic (2%), azelaic (20%), and tranexamic (5%) acids are the pharmacological agents that stand out. Correct application of these substances determines a variable improvement in melasma but often causes adverse reactions such as erythema, itching, and burning at the application site. Vitamin C can contribute to the reduction of melasma and have little or no adverse effects while sunscreens are normally used as coadjuvant therapies. In conclusion, we have compiled specific topical therapies for treating melasma and discussed those that are the most used currently. We consider it important that prescribers and researchers evaluate the best cost–benefit ratio of topical therapeutic options and develop new formulations, enabling efficacy in the treatment with safety and comfort during application, through the reduction of adverse effects.