bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can miRNA profiling be helpful in distinguishing rheumatic disorders?
Authors: Chaszczewska-Markowska Monika , Gębura Katarzyna , Świerkot Jerzy , Sokolik Renata , Bugaj Bartosz , Wielińska Joanna , Bogunia-Kubik Katarzyna 
Published: June 2022

Abstract
Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are inflammatory arthropathies. A combination of genetic, immunological and environmental factors contribute to pathogenesis of these rheumatic diseases. MicroRNAs (miRNAs) are small 18–22 RNA molecules that function as post-transcriptional regulators and are known to be potent regulators of inflammatory responses. Their expression can be altered under conditions of pathophysiological stress, disease or treatment thus may be potentially used as diagnostic and/or prognostic biomarkers. Micro RNA profiles of AS, PsA and RA patients and controls were assessed by miRNA microarrays. We detected some significant differences in miRNA expression levels between patients with various rheumatic disorders and controls. Expression of miR-365a-3p was the only one that differed among AS patients and healthy controls. It was also lower in AS patients compared to PsA cases. Exprassion of miR-125a-5p was significantly down-regulated in both RA and PsA patients as compared to controls. In turn, miR-6891-3p levels were higher in PsA patients than in patients with AS and RA. These results imply that patients with various rheumatic diseases and healthy controls were characterized with diverse miRNA repertoires. As such, miRNA profiling can be potentially used to distinguish AS and RA from PsA disease.
WITHDRAWN: Neuroprotective Potential of Flaxseed Oil in Amelioration of Cadmium Induced Neurotoxicity
Authors: Mishra Devendra Kumar , Srivast Dipti , Fatima Zeeshan , Mohapatra Lucy , Awasthi Himani 
Published: June 2022

Abstract
Introduction:
The current investigation aimed to explore the neuroprotective potential of flaxseed oil (FSO) in the amelioration of cadmium-induced neurotoxicity. Cadmium (Cd) is known as a strong neurotoxin heavy metal, which shows an impact on the brain by initiating oxidative stress and causing influences in the membrane. Flaxseeds have healthful attributes and are a rich source of ω-3 fatty acids: short-chain polyunsaturated fatty acids, secoisolariciresinol diglycoside-SDG, solvent and insoluble filaments, α-linolenic acid, proteins and a variety of antioxidants. The neuroprotective effect of FSO was identified in rats along with the expression of caspase − 3 and Bcl-2 to establish the anti-apoptotic potential of FSO.
Methods
The rats were given the cadmium (5 mg/kg/day) orally for 30 days and simultaneously flaxseed oil (FSO) was also administered at the doses of 2ml/kg/day and 3ml/kg/day for 30 days. Morris water maze test (MWM) and Novel object recognition test (NOR) were conducted to assess the learning and memory parameters. We measured the levels of glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), acetylcholinesterase inhibitory activity (AChE), apoptosis and histopathology studies in the whole brain homogenate.
Results
Cadmium intoxication was allied with substantial damage to learning and memory in MWM and NOR tests. The Cd-ingested group presented a rise in the level of MDA, NO and AChE in the homogenate of the brain and a decline in the levels of GSH allied with the control group. The animals, given the dose of FSO, showed restoration of learning and memory capability with oxidative and cholinergic balance in the brain tissue and also decreased levels of caspase − 3 and Bcl-2 alike to the control sample.
Conclusion
The current study establishes the beneficial effects of flaxseed oil, which increases the level of GSH and antiapoptotic potential, whereas it also decreases the level of MDA, NO, and AChE in the brain which helps in neuroprotection and reduction of neuronal death, which was further confirmed by histopathological observations.
Structural Laser Modification of PbSe Films Electrical and Optical Properties
Authors: Olkhova Anastasiia A. , Patrikeeva Alina A. , Sergeev Maksim M. 
Published: June 2022

Abstract
PbSe chalcogenide films are widely used as photosensitive elements in gas analysis devices. High absorption in the IR spectrum region and low electrical resistance are important characteristics. Continuous laser radiation exposure of films in the near UV range makes it possible to achieve the desired characteristics, replacing oven heat treatment in the technological process. In the considered laser technology, PbSe films are subjected to photothermal action by a spot of focused radiation in the progressive scanning mode. In this work, changes in the optical and electrical film properties were studied, and the mechanism of structural laser modification was also considered.
Application of HPAA-RGD/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis
Authors: Dong Shuai , Xia Qing , Pan Jun , Du Xiao-Long , Wu Yi-Jun , Xie Xiao-Jun 
Published: June 2022

Abstract
Background
There are still no means and molecular markers to identify the invasion ability of thyroid cancer, and the early diagnosis and effective treatment of invasive thyroid cancer are quite difficult in current clinical treatment. In this study, we intend to explore the molecular markers of invasive thyroid cancer, design a targeted drug and provide new insights into the development of invasive thyroid cancer.
Methods
Overexpression and inhibition of circICA1 and miR-486-3p were performed in B-CPAP cells. The effects of circICA1 and miR-486-3p on thyroid cancer cells were assessed by analyzing the proliferation, apoptosis, migration, and invasion of cells. The effects of the regulation of the miR-486-3p/SERPINA1 axis on thyroid cell metastasis was explored by qPCR and western blot analyses. Finally, an in vivo xenograft tumor model was constructed to assess the effects of hyperbranched polyamidoamine (HPAA)-RGD/si-circICA1 on the growth and metastasis of thyroid tumors.
Results
The expression of miR-486-3p in circICA1-inhibited B-CPAP cells was significantly increased. CircICA1 could promote the proliferation and invasion of thyroid cancer cells by regulating the miR-486-3p/SERPINA1 axis. In addition, the loading of HPAA-RGD enhanced the therapeutic effect of si-circICA1 against thyroid cancer.
Conclusion
RGD-modified HPAA loaded with si-circICA1 can effectively treat thyroid cancer metastasis, and is, therefore, a potentially effective treatment strategy for thyroid cancer.
Framework for Detection of Fraud at Point of Sale on Electronic Commerce sites using Logistic Regression
Authors: Alabi Olubunmi F. , David Amos A. 
Published: June 2022

Abstract
Many businesses have been positively impacted by electronic commerce (ecommerce). It has enabled enterprises and consumers to transact business digitally and experience diversity as long as the internet can be accessible and a gadget to surf the internet is available. Several governments have gradually adopted electronic payment throughout the country. The Nigerian government has also done a lot of prodding toward the adoption of a cashless economy, which includes embracing ecommerce. As ecommerce expands, so does actual and attempted fraud through this channel. According to the Nigerian Central Bank, electronic fraud would reach trillions of Naira by 2021. The purpose of this work was to employ logistic regression as a decision-making tool for detecting fraud in e-commerce platforms at the point of sale. The main contribution of this research is a model developed using for detecting fraud at the point of sale on electronic commerce platforms. The accuracy of the result is 97.8 percent. The result of this study will provide key decision makers in ecommerce firms with information on fraud patterns on their ecommerce platforms, this will enable them take quick actions to forestall these fraudulent attempts. Further research should be carried out in developing countries.
Machine Learning-based Predictive Models for Equivalent Damping Ratio of Rc Shear Walls
Authors: YAGHOUBI Siamak TAHAEI , Deger Zeynep Tuna , Taskin Gulsen , Sutcu Fatih 
Published: June 2022

Abstract
Energy-based seismic design is being rapidly developed and suggests that the seismic demands are met by the energy dissipation capacity of the structural members. Equivalent damping ratio is a measure of energy dissipation in structural members that accounts for the post-elastic behavior of the member and provides insight regarding the dynamic response reduction during a seismic event. The present study implements a machine learning (ML) algorithm to estimate the equivalent damping ratio in reinforced concrete shear walls at displacements corresponding to a 1.0% lateral drift ratio. Five different machine learning models, namely, Robust Linear Regression (RLR), K-Nearest Neighbor Regression (KNNR), Kernel Ridge Regression (KRR), Support Vector Regression (SVR), and Gaussian process regression (GPR) were evaluated in order to choose the model with the highest accuracy. Among all models, Gaussian process regression, a machine learning method with successful implementation experiences in civil/structural engineering related problems, is selected to identify the equivalent damping ratio. The developed GPR based algorithm uses a database of 161 rectangular shear walls subjected to quasi-static reversed cyclic loading with geometry and mechanical properties commonly found in building stocks of many earthquake-prone countries. The proposed algorithm estimates the equivalent damping ratio for each specimen by predicting the cyclic dissipated energy and lateral force values as two dependent variables. The model validation results show a mean coefficient of determination (R2) of about 0.89; a relative root mean square error (RELRMSE) of about 0.14 and a mean absolute percentage error (MAPE) of 10.44%, which is considered a substantially accurate prediction for such a complex problem. An open-source model and entire database is provided which can be used by researchers and also design engineers. The proposed predictive model enables comparing the damping capacity of shear walls and the outcomes of this study are believed to contribute to the energy-based design or performance evaluation procedures in terms of predicting the energy capacity of shear walls.
The critical state characterization of east coast sand (ECS) and calibration for use with an advanced critical state soil constitutive model
Authors: Bolarinwa Ademola , Kalatehjari Roohollah , Safuan Ahmad Rashid 
Published: June 2022

Abstract
This paper outlines the findings of a laboratory-based study to investigate the properties and undrained flow failure behavior of East Coast Sand (ECS). ECS is a commonly encountered coastal deposit from the upper North Island of New Zealand. This work aims to derive soil parameters for an advanced constitutive soil model (NORSAND) to enable predictive analyses of flow failure potential using the critical state framework. The emphasis in the study is placed on the undrained strength behavior under static, triaxial compressive loading conditions at confining pressures in the range of typical engineering interest and for a range of soil densities considered in loosely deposited sands common to nearshore marine and estuarine environments. The research objective of establishing the basic soil properties and intrinsic advanced geomechanical properties of ECS from Auckland was achieved through laboratory experiments and matching simulations for five different aspects of its undrained behavior under static loads. It was shown that loosely deposited ECS within mean effective stresses ranging between 50kPa and 200kPa can be susceptible to expensive flow failures of structures built on or with them. Therefore, the re-engineering of ECS by adequate soil improvement is required when used in earthworks.
LncRNA PVT1 facilitated growth and metastasis of colorectal cancer by sponging with miR-3619-5p to regulate TRIM29 expression
Authors: Sun Zhenni , Li Xutong , Shi Yanyan , Yao Yasai 
Published: June 2022

Abstract
Background
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide, and one of the main causes of death is tumor metastasis. The tens of thousands of long non-coding RNA (lncRNAs) currently identified have unique functions in a variety of malignant tumors, including in CRC. But the exact mechanism of lncRNAs as biomarker for CRC is still relatively lacking. This study clarified that the lncRNA PVT1 is involved in the growth and metastasis of CRC.
Methods
We analyzed the lncRNAs in CRC which is differentially expressed by using the TCGA. PVT1 expression and CRC prognosis were analyzed base on GEPIA and lnCAR databases. In order to reveal the function of PVT1 on CRC, CCK-8, Transwell, wound healing and IF assays were performed in vitro. The in vivo assays also used to further explore the effects of PVT1.
Results
Our results indicated that PVT1 was highly expressed in CRC and made the prognosis of CRC even worse, which showed good diagnostic value. Transfection of sh-PVT1 or pcDNA3.1-PVT1 reduced or increased proliferation, migration, invasion and EMT of CRC cells. PVT1 and miR-3619-5p were co-expressed in CRC cytoplasm, and PVT1 acted as a ceRNA by sponging miR-3619-5p to up-regulate TRIM29 expression. Overexpressing miR-3619-5p and knockdown of TRIM29 reduced proliferation, migration, invasion and Epithelial-Mesenchymal Transition (EMT) of CRC cells. However, simultaneous upregulation of PVT1 and miR-3619-5p or knockdown of miR-3619-5p and TRIM29 could rescue the malignant phenotype of CRC cells.
Conclusions
We first clarified the ceRNA mechanism of PVT1 in CRC, which formed a regulatory function by sponging with miR-3619-5p to regulate TRIM29.
Intensified cytarabine dose during consolidation in AML patients under 65 years is not associated with survival benefit: real-world data from the German SAL-AML registry
Authors: Hanoun Maher , Ruhnke Leo , Kramer Michael , Hanoun Christine , Schäfer-Eckart Kerstin , Steffen Björn , Sauer Tim , Krause Stefan , Schliemann Christoph , Mikesch Jan-Henrik , Kaufmann Martin , Haenel Mathias , Jost Edgar , Bruemmendorf Tim , Fransecky LArs , Kraus Sabrina , Einsele Hermann , Niemann Dirk , Neubauer Andreas , Kullmer Johannes , Seggewiss-Bernhard Ruth , Goerner Martin , Held Gerhard , Kaiser Ulrich , Scholl Sebastian , Hochhaus Andreas , Reinhardt Hans , Platzbecker Uwe , Baldus Claudia , Müller-Tidow Carsten , Bornhäuser Martin , Serve Hubert , Röllig Christoph 
Published: June 2022

Abstract
Higher doses of cytarabine appear to improve long-term outcome in acute myeloid leukemia (AML), in particular for younger patients. To this end, the optimal dosage of single agent cytarabine in consolidation therapy remains elusive. Here, we assessed the impact of different dosages of cytarabine consolidation after 7 + 3 induction on outcome in a large real-world data set from the German Study Alliance Leukemia-Acute Myeloid Leukemia (SAL-AML) registry. Patients below 65 years of age, registered between April 2005 and September 2020, who attained complete remission after intensive induction and received at least one consolidation cycle with intermediate (IDAC) or high dose cytarabine (HiDAC) were selected. To account for differences in patient and disease characteristics between both groups, the average treatment effect was estimated by propensity score weighting. Six-hundred-forty-two patients received HiDAC consolidation with median dosage of median 17.6 (IQR, 16.5–18.0) g/m² for a median number of 3 cycles (IQR, 2–3), whereas 178 patients received IDAC consolidation with 5.9 (IQR, 5.7–8.6) g/m² for a median of 2 cycles (IQR, 1–3). Both groups differed significantly in some important characteristics (age, sex, cytogenetic risk group, ECOG performance status, disease status, HCT-CI, number of induction cycles). After propensity score weighting for differences in patient and disease characteristics, relapse-free survival after 2 years was comparable between HiDAC-treated (55.3%) and IDAC-treated (55.6%) patients. Moreover, no significant differences in overall survival were observed after 2 years (84.7 vs. 80.6%). Notably, more patients treated with IDAC received allogeneic hematopoietic cell transplantation in first remission (37.6 vs. 19.8%, p < 0.001). Censoring for allogeneic hematopoietic cell transplantation in first remission revealed no significant survival difference with regard to cytarabine dosage. This retrospective analysis suggests no significant benefit of high dose cytarabine compared to intermediate dosages in consolidation for AML patients under 65 years of age, independent of European LeukemiaNet (ELN) risk group.
Positive response of a recurrent clear cell sarcoma to neoadjuvant targeted therapy combined with chemotherapy: a case report
Authors: Tao Junyue , Liu Chang , Liu Sha , Bian Xiaokang , Yang Hao , Liang Chaozhao , Du Yingying , Zhang Chao , Yin Yu , Zhou Jun 
Published: June 2022

Abstract
BackgroundRenal clear cell sarcoma (CCSK) is a rare and highly invasive malignant renal tumor that easily relapses after treatment. Recurrent CCSK responds poorly to chemotherapy. Therefore, a combination of effective targeted drugs has become an urgent need for the treatment of recurrent CCSK.Case presentationHerein, we report on a patient with CCSK recurrence after surgery who responded well to neoadjuvant targeted therapy combined with chemotherapy. The patient received 6 courses of neoadjuvant targeted therapy combined with chemotherapy. After treatment, the tumor had significantly reduced in size and the recurrent tumor and part of the liver were resected. No tumor recurrence or metastasis was found during follow-up 3 months after the operation.ConclusionsWe believe that targeted therapy combined with chemotherapy can be a treatment option for patients with recurrent CCSK as it provides an opportunity for surgical resection of the tumor.
Spatial and temporal distribution patterns of human Echinococcosis in Baghdad-Iraq using GIS
Authors: Al-Obaidi Mohammed , Nayyef Hanan J. , Mohammed Sinai W. , Jabbar Faheema , Hanoon Ahmad Y. , Taqi Estabraq A. 
Published: June 2022

Abstract
Hydatid disease (HD) or cystic echinococcosis (CE) is a complex and neglected disease caused by the parasite Echinococcus granulosus that causes health and economic loss. The data of disease were obtained from the Center of Communicable Diseases/ Baghdad/Iraq, for the period 2013 to 2016. Global information system (GIS) was used to create the study area and cases distribution. Total recorded number of CE cases was 61 cases distributed among different genders, age groups, and sectors in Baghdad province. The results showed that the distribution of hydatid cyst infections according to year was higher in the year 2013 (36.1%) than in other years (2014, 2015, and 2016) respectively. Percent of female infection with CE was (57%), more susceptible than male (43%). It was observed that the Sadder City (31.1%) was at greater risk of hydatid cyst infections than other sectors of Baghdad. Also, the study was found that the most susceptible age group to this disease was the age between (15–45y (73.8%)) than other age groups. This study concluded a decrease in infection by cystic echinococcosis (CE) over the previous years. This indicated the increased public awareness of the disease's transmission. The aim of this study was to determine the spatial and temporal distribution of the disease in different locations in Baghdad city.
Sustainable supply chain system for defective products with different carbon emission strategies
Authors: Priyan S. , Mala P. , Palanivel M. 
Published: June 2022

Abstract
Humans are gradually altering the atmosphere and the globe's temperature by burning fossil fuels and discarding items due to error. This amplifies the conservatory cause and global warming by adding huge amounts of greenhouse gases to those already existing in the ambience. One of the strategies to reduce emissions and costs is to amend our firm to perform in an eco-friendly manner. The advent of various green solutions to be addressed in the supply chain (SC) is to blame for environmental issues and increased government pressure. In this article, the consequences of green technology and human error on the vendor-buyer complex SC system are examined using two carbon emission strategies: carbon taxes and limited total carbon emissions. It comprises the buyer inspecting each shipping lot for faulty items that may have come from the vendor's production process. The categorization of faulty and perfect items makes the inspection procedure difficult for the customer. To reduce overall cost, a mathematical model is designed in two alternative scenarios. This entails creating a complicated method to arrive at optimal answers that can be demonstrated both analytically and numerically. Sensitivity analysis is used to explore the implications of changing the core parameter values on the optimal solution. According to the findings, rising the carbon tax eases emissions, and the company has further alternatives to minimize carbon emissions generated by industries activity using green technology.
Huaier effects on functional compensation with destructive ribosomal RNA structure after anti-SARS-CoV-2 mRNA vaccination.
Authors: Tanaka Manami , Tanaka Tomoo , Zhu Xiaolong , Fei Teng , Lin Hong , Luo Zhu , Sadahiro Sotaro , Suzuki Toshiyuki , Maeda Yuji , Wei Ding , Lu Zhengxin 
Published: June 2022

Abstract
Although striking effects of vaccination strategy against COVID-19 world-wide, a long-term influence by sequential viral mRNA injections are unknown. We analysed biological alterations by total RNA sequencing in Pfizer-BioNTech vaccinated normal healthy volunteers and cancer patients, with or without adjuvant Huaier therapy. A significant destruction in ribosomal RNA structures was identified, enhanced by serial shots. Unlike the destruction caused by chemotherapy with platinum (II) complex, progressive destruction in 18S ribosome was identified even at 6 months after vaccination. The influence resulted in massive inhibition of translation and transcription, significantly in intra/inter neural signaling transfer and in lipid metabolism, related to ageing process. Huaier compensated these dysfunctions by miRNA-mediated transcriptional control, by typical activation in PI3K/AKT signaling pathway. Gene Ontology analysis revealed spontaneous virion production in number even after 3 months of the first vaccination. Present study indicated that the adjuvant therapy like Huaier compensates accelerated ageing process by mRNA vaccination.
Discovering short-range ordering in a medium entropy alloy via intelligent big data
Authors: Cao Cecilia , Guo Amy , Yang Haokun , Zhang Ayden , Li Wen Jung , Yang Jiong , Zhang Shouyang 
Published: June 2022

Abstract
Short-range orders (SROs) become more interesting in an intriguing new class of metallic materials – High-Entropy Alloys (HEAs) or Medium-Entropy Alloys (MEAs), that contain multi-principal elements. However, from the atomic level and the compositional viewpoint, observing the SRO in HEAs or MEAs is still very challenging, because it is difficult to distinguish the elements with very closed atomic numbers using electron microscopies. Here we directly observed the SRO in a medium-entropy alloy through deciphering the big data by atomic probe tomography (APT) via a new machine learning method. Using our matching learning method, the nearest neighbors of the detected elements, preferred bonds of each atom, in the APT data can be achieved. Our method offers a new pathway to observe SRO directly not only in those compositionally-complex alloys but also in the traditional dilute alloy systems, which can accelerate the design of advanced materials with favorable SROs for achieving desired properties.