bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental illness pathogenia: Anxiety disorders, an evolutive vision
Authors: Garcia L. Carpio , Villarroel C. Martín , Revuelta M. Sánchez , Matsuura J. , Cutanda J. Dominguez , García E. 
Published: February 2022

IntroductionThere are many authors that follow and develop Pinel-hypotheses about unitary psychosis, joining recent discoveries in neuropathology and neurochemistry, supporting the vision of mental illness as neurodevelop disorders. The classification they suggest, distinguishes early, late neurodevelop disorders, and those related to traumatic factors, what determine an evolutive vision of this pathology. In terms of anxiety symptoms/disorders, they have been usually associated with categorical pathology, and treated focus on symptoms,unfortunately relapses are very frequent.ObjectivesProving that the evolutive vision may ease a change on the intervention of anxiety disorders, that would propound different therapeutic alternatives.MethodsA bibliographic search was performed from different databases, showing throw aspects related to main etiopathogenic theories about anxiety disorders from an evolutive vision.ResultsEvolutive-Psychology raises that anxiety is a concomitant process to development, that grows progressively and is necessary to induce changes in it. However a high level of anxiety might block that process or causes alterations. In that sense, anxiety-disorders may be related to an excess of anxiety that provoke a fault in present handling mechanisms. According to classic dynamic-theories, these mechanisms are associated with defence concept, but now we can link them to neurobiological development. From this point, there exists an asymmetric neurological maturation through childhood-adolescence that translates different manifestations of anxiety along development, initially more related with external contemption and relationship with caregiver, but later with hormonal pulses, physical changes and separation from family.ConclusionsThe evolutive vision allows to understand development fluctuation of anxiety symptoms along the growth process, more accurately than categorical classic tendency.DisclosureNo significant relationships.
Obsessive symptoms as first alert of psychosis: Two cases report
Authors: Garcia L. Carpio , Villarroel C. Martín , Revuelta M. Sánchez , Cutanda J. Dominguez , Matsuura J. , García E. 
Published: February 2022

IntroductionConcomitant presence of obsessive-compulsive symptoms(OCS)is relatively frequent in psychotic patients and there are different hypotheses trying to explain the origin of them as pathology evolution,comorbid disorder,defence mechanism,or even a medication side-effect,but it is difficult to make a precise evaluation of these symptoms and the mechanisms involved.SometimesOCS are the first manifestation toappear without any other areas affected,and psychotic disorder comes later with initial symptoms in that domain.ObjectivesEvaluate the association between OCS and psychosis to document pathogenia of both entities.MethodsA bibliographic search was performed about this topic.We present two cases of patients that have been referred to our unit: A34year old man, a usual consumer of cannabis,who shows checking and organizing compulsions that interfere significantly with their life.Consumptions grew progressively until they became daily,trying to decrease partly this behaviour. He comes to an addiction unit where he achieves abstinence,but immediately shows an important functional-impairment, adding to the previous compulsions new ones,and also thought blocking,social retraction and personality change. He starts taking antidepressant and benzodiazepines to reduceOCS, and weeks later begins a manic episode with delusions as a bipolar-disorder debut. A29year old man, with a history of familiar obsessive personality,that begins to worry about physical appearance and starts compulsive behaviour focused on exercise preventing him from daily activities.No response to antidepressants, he started antipsychotics and develop referential-symptoms.ResultsBoth are atypical presentations of bipolar and schizophreniform disorders withOCS,where the beginning of treatment causes psychosis-symptoms not previously developed.ConclusionsFrequent doubts are what factors determine the eclosion.The triggers are not clear and neither the related-pathology.DisclosureNo significant relationships.
Evaluation of tava program to improve the quality of life in young adults with autism spectrum disorders (ASD)
Authors: Pedrero A. Alvarez , Uribe I. Parra , Muñoz R. , Reina N. , Llorens M. , Palacin A. , Membrives S. , Monreal J.A. , Vidal D. Palao 
Published: February 2022

IntroductionAutism spectrum disorders (ASD), is a population that does not usually receive specific treatment.ObjectivesThe main objective of the present study is to evaluate whether specific interventions within the TAVA program (transition program to adult life for patients with ADS), produce significant improvements in the quality of life of young adults with ASD.MethodsThis is a prospective randomized clinical study of patients with ASD (according to DSM-5 criteria) seen in outpatient of the Parc Tauli University Hospital in Sabadell (Barcelona) since September 2017. We compared the quality of life, functionality, caregiver burden, and comorbidity of patients in TAVA program (beneficiaries of group therapy and specific medical and psychosocial interventions), with that of control patients (treatment as usual), after 2 years of intervention.ResultsOur sample is composed of 12 patients with ASD. The average age is 18.4 years. 83% of the sample are men (n = 10). 5 of the patients belonged to TAVA and the other 7 were controls. Overall, TAVA patients presented improvement in the ZARIT and BAI scales compared to control patients. The control patients evolved less favorably in the AAA, SRS and RAAS levels compared to TAVA.ConclusionsSpecific interventions in adults with ASD, improve the caregiver’s feeling of overload and the patients anxiety, compared to the usual interventions. The lack of regulated interventions produces an unfavorable evolution of the core symptoms of autism. More studies are needed to specify efficient interventions to improve the quality of life of adults with ASD.DisclosureNo significant relationships.
Psychological distress among greek parents of children with an autism spectrum disorder: Is there a link to anxiety symptoms in neurotypical offspring?
Authors: Koukouriki E. 
Published: February 2022

IntroductionParents of children with an autism spectrum disorder (ASD) are at higher risk of suffering from mental health problems (MHP) than parents of children with other developmental disabilities. Research on the general population documented that MHP in parents contributes as a significant risk factor for maladjustment outcomes in their offspring, while parental anxiety disorders in particular have been associated with a higher prevalence of anxiety disorders in the offspring. However, evidence concerning possible associations between parent-offspring psychological problems in the case of ASD-families is scarce and inconsistent.This study forms a part of a larger PhD study and some preliminary findings have been partially discussed in previous work.ObjectivesTo investigate any association between anxiety symptoms in neurotypical offspring (ASD-siblings) with parental MHP.Methods118 parent-child-dyads from ASD-families that fulfilled inclusion criteria participated in this study and answered a demographic questionnaire. Parents were administered the GHQ-28, while the children answered the STAIC-A-Trait. A hierarchical multiple regression was performed to test the hypothesis.ResultsParticipating parents demonstrating poorer mental health, with 53 (44.9%) of them considered as suffering from psychological distress according to the score of GHQ-28. Furthermore, hierarchical regression showed that STAIC-(A-Trait) total score of ASD-siblings was associated with parental anxiety (std beta=0.292; p=0.29;model 1) and this association persisted after demographics entered the model (std beta=0.300; p=0.029; model 2).ConclusionsThis study shows a significant association between parental psychological distress and anxiety in the neurotypical offspring in ASD-families, highlighting the need to provide all members of ASD-families with the appropriate services.DisclosureNo significant relationships.
The prevalence of anxiety disorders among young people in europe: A systematic review and meta-analysis
Authors: Sacco R. , Camilleri N. , Umla-Runge K. 
Published: February 2022

IntroductionThis systematic review estimates the pooled prevalence (PP) of anxiety disorders (ADD) among 5-to-18-year-old YP living in Europe, based on prevalence rates established in the last five years (LFY).ObjectivesTrends of prevalence rates across countries, gender and level of education were analysed. The random effects pooled prevalence rate (REPPR) for AD was calculated.MethodsA search strategy was conducted on three databases. Studies were also identified from reference lists and grey literature. Eligible studies were evaluated for reliability, validity, bias, and the REPPR for AD was calculated.ResultsThe European REPPR for AD is calculated at 7.9% (Figure 1). The REPPR for each anxiety disorder is shown in Figure 2.ConclusionsBased on the results in this systematic review, AD are the most prevalent mental disorders among young people in Europe. Early diagnostic and intervention strategies for AD may improve the mental health and wellbeing among young people.DisclosureNo significant relationships.
KKI-NECT: Kennedy krieger institute’s network for early childhood tele-education (US)
Authors: Leppert M. , Harrison J. 
Published: February 2022

IntroductionThe Kennedy Krieger Institute Network for Early Childhood Tele-Education (KKI-NECT) is a federally funded ECHO project. Its hub consists of a child psychiatrist, developmental pediatricians and a behavioral psychologist. Its community partners are primary care providers(PCPs) in underserved areas. Its goal is to create local experts in early childhood behavioral, emotional and developmental disorders.ObjectivesAfter attendance at this session, the learner will be able to: 1. report the rates of co-occurring developmental, behavioral and emotional disorders presented by primary care participants 2. explain the efficacy of case based learning and a structured curriculum as a mechanism for expanding the workforce. The goal of this presentation is to build awareness of and interest in ECHOs specifically targeted to child behavioral, emotional and developmental issues.MethodsDr. Leppert will discuss KKI-NECT, particularly the process of procuring funding, setting up an ECHO, and getting institutional “buy-in". She will describe the use of case based learning and a structured curriculum in a longitudinal CME program, report the comorbidities in cases that participants present for discussion, and demonstrate the impact on participants’ practice.ResultsData from four cohorts demonstrate that PCPs showed increased comfort levels, improved knowledge of behavioral, emotional and developmental disorders. PCPs expanded the scope issues they could address in their practice as a result of participation in KKI-NECT.ConclusionKKI-NECT is a viable response to the workforce shortage of child psychiatrists by confidently increasing the role of the PCP in treating childhood developmental and mental health disorders.DisclosureNo significant relationships.
Relationship between metabolic syndrome and functioning in patients with bipolar disorder type 1
Authors: Şahmelikoğlu Onur Ö. , Uluyol Ö. Baş 
Published: February 2022

IntroductionThe available literature indicates a possible association between metabolic syndrome (MS) which is highly prevalent among patients with bipolar disorder (BD), and functioning.ObjectivesWe sought to compare differences in functional areas of patients with Bipolar Disorder Type 1 (BPD-1)with and without MS in euthymic period.MethodsThis study included 69 euthymic BPD-1 patients without MS and 46 age- and sex-matched BPD-1 patients with MS. All participants completed a sociodemographic form; took the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Young Mania Rating Scale score, and Bipolar Disorder Functioning Questionnaire. MS was diagnosed according to the International Diabetes Federation (IDF) criteria.ResultsAll of the functioning areas were significantly lower in the BPD-1 with MS group than in the without MS group (p < 0.05). Moreover age at onset of disease was significantly lower in BPD-1 group with MS than without MS (p < 0.05). Number of suicide attempts was significantly higher in BPD-1 group with MS than without MS (p < 0.05). Catatonic and melancholic depression were significantly more prevalent in the BPD-1 with MS than without MS (p < 0.05).ConclusionsOur findings suggest that MS might have an effect on functioning in BD patients even in euthymic period.DisclosureNo significant relationships.
Uric acidas a predictor of bipolar disorder type 1
Authors: Uluyol Ö. Baş , Onur Ö. Şahmelikoğlu 
Published: February 2022

IntroductionIt has been shown in the studies that purinergic system dysfunction might have an effect on pathophysiology of bipolar disorder.ObjectivesIn this study, our aims were to compare uric acid levels between patient with bipolar disorder type 1 (BPD1) and healthy controls (HC) and to evaluate the validity of uric acid in predicting bipolar disorder.MethodsConsecutive outpatients with a diagnosis of euthymic BPD-1 (n=75) and HC (n=75) were included in the study. The subjects were evaluated with Sociodemographic Data Form, Young Mani Rating Scale (YMRS), Beck Depression Scale. Serum uric acid was measured using an auto analyzer.ResultsSerum uric acid level in BPD1 group was significantly higher than HC. Significant efficacy of uric acid value was observed in the differentiation of BPD1 and HC [Area under the curve 0.708(0.626-0.790)]. Significant efficacy of uric acid 5.4 cut off value was observed in the differentiation of BPD1 and HC [Area under the curve 0.667 (0.579-0.8754)]. Sensitivity was 50.7%, positive predictive value (PPV) was 74.5%, specificity was 82.7%, negative predictive value (NPV) was 62.6%.ConclusionsSerum uric acid value is effective in detecting bipolar patients.DisclosureNo significant relationships.
Emotion regulation in euthymic bipolar patients in Tunisia
Authors: Messedi N. , Mhiri E. , Charfeddine F. , Bouattour W. , Aribi L. , Aloulou J. 
Published: February 2022

IntroductionBipolar disorder is presumed to involve difficulties in emotion regulation. However, little is known about the specific emotion regulation profile associated with this disorder.ObjectivesTo study emotion regulation in bipolar patients in remission phase and to determine the factors correlated with it.MethodsA cross-sectional, descriptive and analytical study of 30 patients followed for bipolar disorder in remission, at the psychiatric outpatient clinic at the Hédi Chaker University Hospital in Sfax. We used a socio-demographic and clinical data sheet and the Cognitive Emotion Regulation Questionnaire (CERQ) which assesses cognitive strategies (maladaptive and adaptive) for regulating emotion.ResultsThe mean age of the patients was 43.77 years, the sex ratio was 0.5. Bipolar I disorder was diagnosed in 93% of patients. A good adherence to treatment was found in 86.7% of cases and a good social integration in 40%. The mean total score of the adaptive CERQ was 66.73 and the most used adaptive strategy was acceptation (mean score =13.87), while the mean total score of the maladaptive CERQ was 36.7 and the most used maladaptive strategy was self blame (mean score =9.47). Adaptive cognitive emotion regulation was predominant in 93.3% of patients. It was significantly correlated with good adherence to treatment (p = 0.047) and good social integration (p = 0.026).ConclusionsOur patients with euthymic bipolar disorder showed a satisfying level of adaptive emotion regulation strategies. A cognitive remediation seems important to embetter this capacity and improve the income of the disease.DisclosureNo significant relationships.
Child maltreatment, attachment and psychopathology: A case report
Authors: Lietor M.D.C. Molina , Cuevas I. , Prieto M. Blanco 
Published: February 2022

IntroductionThe exposure to child maltreatment increases the lifetime risk for many psychopathological symptoms: depression, anxiety disorders, bipolar disorder, schizophrenia, post-traumatic stress disorder, personality disorder and dissociation. Besides, adopted children, especially those with a history of institutional living before adoption, are at greater risk for a range of developmental, behavioral and attachment concerns. The case report is of a 17-year-old male, with reactive attachment disorder (RAD). He suffered child maltreatment in his family of origin before the international adoption.ObjectivesThe aim of this study is to present a case-report illustrating the relationship between chil maltreatment, adopted children and the reactive attachment disorder.MethodsA bibliographic search was performed about reactive attachment disorder. Information regarding the clinical case was obtained by consulting the patient’s file.ResultsA 17-years-old male who was adopted at age of 9 from Spain. According to reports from the orphanage, the patient suffered severe maltreatment by his family of origin, with scars on his back. The patient presents impulse control disorder, with verbal and physical heteroaggressiveness in situations of frustration, hunger and sleep. He stopped attending the institute at the age of 12, with marked isolation and reversal of the sleep-wake cycle. His treatment plan are partial hospitalization, psychotherapy and pharmacotherapy.ConclusionsBoth child maltreatment and adoption are risk factors for the presence of psychopathology during the lifetime. Especially during the pre-adoption process and the first years after adoption, both the family and the child should be able to use specialized Mental Health services.DisclosureNo significant relationships.
Risk factors for severity of social withdrawal in adolescence: Understanding hikikomori as a spectrum
Authors: Hamasaki Y. , Nakayama T. , Michikoshi S. , Hikida T. 
Published: February 2022

IntroductionSocial withdrawal, or hikikomori, is one of Japan’s most serious psychosocial issues. The concept gained international attention around 2010 and widespread psychiatric epidemiological studies have since been conducted.ObjectivesWith an understanding of the extensive range of hikikomori circumstances as a spectrum, we aimed to quantitatively measure the severity of hikikomori in adolescent subjects, an age group considered particularly susceptible to the condition, and to identify factors associated with its severity.MethodsWe selected population demographics, socioeconomic data, and psycho-behavioral characteristics as factors related to hikikomori and explored their associations with hikikomori severity using cross-sectional analysis. Subjects were a patient group of middle school students examined as outpatients at a psychiatric clinic during adolescence for a chief complaint of hikikomori and a control group of middle school students matched for sex and age. Subjects’ parents completed a questionnaire pertaining to their child’s hikikomori symptoms and living environment along with the Child Behavior Checklist (CBCL). The data collected was then statistically analyzed.ResultsT-test results demonstrated that scores for all CBCL syndrome scales were significantly higher in the patient group, but no scores fell within the clinical range. Multiple regression analysis revealed that being anxious/depressed, somatic complaints, lack of communication between parents, and overuse of the Internet were statistical predictors of hikikomori severity.ConclusionsIt may be possible to prevent hikikomori from becoming severe if the above predictors are used to identify high-risk individuals requiring active intervention while hikikomori is at an early stage.DisclosureNo significant relationships.
Maternal mediation strategies during interaction with toddlers- a comparison of dyads with autism spectrum disorder (ASD) and dyads with typical development (TD)
Authors: Mimouni-Bloch A. , Oren A. , Dromi E. 
Published: February 2022

IntroductionDuring interactions with toddlers, mothers use various mediation strategies to encourage mutual play. Such mediation skills play an important role in the development of toddlers’ communicative skills. Autism Spectrum Disorder (ASD) introduces challenges to this interaction.ObjectivesTo study the use of maternal strategies during interaction with ASD and TD toddlers at early lexical levels.MethodsNine ASD and fifteen TD dyads participated. Toddlers were matched by lexical levels. The mean age in the ASD was 31.5 months and in TD - 17 months. Each dyad was video-recorded three times, during naturalistic interaction. Mothers’ verbal mediation strategies were divided into five main communicative categories.Results1. Exact repetition of toddler’s utterances was similarly used and increased in both groups across the three visits (f (2,44)=3.77, p< 0.05). 2. Significant differences were found between the two groups regarding strategies associated with control of the interaction eg mothers of toddlers with ASD (MASD) made more frequent attempts to redirect their child’s attention (F (1,22)= 74.56, p<0.01). 3. MASD had higher indices of overall talkativeness (F (1,22)= 5.43, p<0.05); use of nonverbal means (F(1,22)= 9,51, p<0.01); simultaneous use of different means of communication (F (1,22)=19.8, p<0.01).ConclusionsOur results highlight that in some respects, maternal mediation strategies reflect the child’s lexical level. However, our main finding is a distinct interaction style expressed in MASD’s elevated use of verbal and nonverbal mediation strategies. This, in hope of maintaining continuous interaction that could not be otherwise achieved due to their toddlers’ difficultiesDisclosureNo significant relationships.
European brain research area: The operational level
Authors: Aarts K. , De Witte E. , Kramer S. , Iannone D. , Destrebecq F. , Di Luca M. 
Published: February 2022

Brain research in Europe is a rapidly evolving field, and increasingly at the forefront of science. Although considerable amounts of knowledge and innovative approaches have been generated, the translation into new health interventions is hindered by excessive fragmentation. Effective and efficient collaboration and cooperation among the various initiatives are often identified as a key success factor to achieve brain research full impact. EBRA fully responds to these needs by bringing together the various stakeholders and major brain research initiatives, at European level and beyond. EBRA creates the conditions for real and effective cross fertilisation, dialogue, building consensus and exploiting research potential. On the operational level, EBRA facilitates the emergence of research projects in specific areas in active clusters. A cluster is understood as a research community that can be directed towards basic research, clinical research and/or methodological approaches under a common topic and disease area within brain research. EBRA support clusters to: 1. Consolidate or expand further the research community expand their community, 2. Engage with policy makers and other relevant stakeholders, 3. Build consensus on various issues (research priorities, research roadmap, data sharing, etc.), 4. Promote links with existing research infrastructures, 5. Increase the visibility of the research community through communication and dissemination activities, 6. Coordinate the development of position/consensus papers, white papers, guidelines, meeting reports and/or other cluster outcomes. EBRA currently has 6 existing clusters: EPICLUSTER, Prevention of Severe Mental Disorders (PSMD)-cluster, TRISOMY21-cluster, BRAINFOOD-cluster., PREMOS-cluster and ECIB-cluster.DisclosureNo significant relationships.