bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features of Acne in Primary Care Patients Assessed Through Teledermatology
Authors: Giavina-Bianchi Mara , Azevedo Maria Fernanda Dias , Cordioli Eduardo 
Published: January 2022

Introduction/Objectives: Acne is present in about 90% of teenagers and 12% to 14% of adults. Face and trunk are the most affected areas. Lesions can result in postinflammatory hyperpigmentation and scarring, leading to reduced quality of life. Asynchronous teledermatology has been increasingly used around the world, facilitating patient access to dermatologists. Our objectives were to assess: (1) clinical features of acne patients according to gender, age, severity, site of lesions, excoriation, postinflammatory hyperpigmentation (PIH), and atrophic scar (AS) and (2) how many referrals to in-person consultations with dermatologists could be avoided using asynchronous teledermatology in primary care attention? Methods: We analyzed images, demographic and clinical data of 2459 acne patients assisted by teledermatology, with the aim to confirm the diagnoses, to classify acne severity according to grades I to IV, and to search for the presence of postinflammatory hyperpigmentation, atrophic scars, and/or excoriated acne (EA). We compared the clinical and biological data, looking for associations among them. Results: Acne severity and age were associated with the most common sequels: postinflammatory hyperpigmentation (mainly on the trunk and in females, P < .0001) and atrophic scars (mainly on the face and in males, P < .0001). We also observed different frequencies according to age and sex: 13 to 24 years in males ( P = .0023); and <12 ( P = .0023) and 25 to 64 years old ( P <.0001) for females; 68% of the patients had no need for in-person dermatologists’ referral, being kept at primary care attention with proper diagnosis and treatment. Conclusion: Clinical features of acne and its sequels differ according to gender, age, site, and severity. The new findings of PIH associated with women and AS, with men, may help offer a more personalized management to patients. Teledermatology was suitable for the majority of the acne cases in primary care.
MTP Arthrodesis: Outcomes of Crossroads Dynaforce and Stryker Locking Plate
Authors: Andrews Nicholas A. , Halstrom Jared R. , Ray Jessyca , Fellows Kenneth J. , Harrelson Whitt , Dib Aseel G. , Agarwal Abhinav , Elattar Osama M. , Shah Ashish 
Published: January 2022

Category: Ankle; Midfoot/Forefoot Introduction/Purpose: Metatarsophalangeal (MTP) joint arthrodesis is commonly performed for end-stage hallux rigidus with largely satisfactory results. While current literature demonstrates union rates in the low 90's, there is still room for evolution of techniques and fixation constructs. The new Crossroads Dynaforce plate provides area for direct integration of a compression staple into the dorsal locking plate construct. The purpose of this present study was to compare outcomes of this new plating system to a standard dorsal locking plate from Stryker. Methods: Patients undergoing primary MTP arthrodesis from 2010-2020 were identified. Patients receiving Crossroads Dynaforce plates (23 patients) and Stryker Dorsal locking plates (21) for Hallux Rigidus were selected. Radiographic follow-up of >12 weeks and no ongoing ipsilateral infection were required for inclusion. Medical records were examined for patient characteristics, operative variables, and complications. PROMIS physical function, pain interference, and depression domains were collected postoperatively in addition to Foot Function Index (FFI). Results: The median age was 57.0 (IQR 16.0) with the average BMI of 30.4 (SD 11.2). No patient comorbidities or demographics were significantly different between Stryker and Crossroads groups. Importantly, the preoperative hallux valgus and intermetatarsal angles did not vary between groups. The use of an interfragmentary screw was significantly higher in the Stryker cohort 20/21 (95%) compared to 16/23 (70%) The rate of wound dehiscence, deep infection, and reoperation did not vary between groups. The nonunion rate did not differ between groups and was 3/21 (14.3%) in the stryker cohort compared to 1/23 (4.3%) in the Crossroads group. Patient reported outcomes measures did not differ between groups and were completed at an average of 2.2 years postoperatively (SD 1.9). Conclusion: The Crossroads Dynaforce plate provides comparable outcomes to a legacy dorsal locking plate from Stryker in hallux rigidus. In addition to clinical outcomes, patients report similar levels of function at intermediate term follow up.
Impact of COVID-19-associated anxiety on the adherence to intravitreal injection in patients with macular diseases a year after the initial outbreak
Authors: Liu Siyin , Ng Jonathan K.Y. , Moon Emily Haejoon , Morgan Daisy , Woodhouse Natalie , Agrawal Dakshita , Chan Laura , Chhabra Ramandeep 
Published: January 2022

Background: As the primary burden of treating COVID-19 patients began to ease in the United Kingdom, ophthalmology clinic volume within the National Health Service has since recovered. Alarmingly, the rate of non-attendance remains higher than the pre-pandemic level. Purpose: The purpose was to assess how the perceived risk of contracting coronavirus disease 2019 (COVID-19) influences the willingness of individuals with sight-threatening macular conditions to attend intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection appointments during the second wave of the pandemic. Methods: This prospective cross-sectional survey was conducted at the Macular Treatment Centre, Manchester Royal Eye Hospital. Patients who missed their appointment in January 2021 were invited to complete an anonymous survey over the telephone. The survey consisted of two parts: (1) a 23-item questionnaire aiming to assess fear of contracting COVID-19 in different hospital-related settings; and (2) the validated COVID-19 Anxiety Syndrome Scale (C-19ASS) to evaluate COVID-19-related anxiety. Results: A total of 104 patients agreed to participate in the survey. Only a small proportion of patients believed COVID-19 vaccination (23 out of 88, 26.1%) had influenced their willingness to attend injection appointments. Majority of patients felt concerned about contracting COVID-19 during hospital appointments ( n = 63, 60.6%). Only a minority of patients ( n = 36, 34.6%) agreed with the hospital guidance on minimising clinical examinations during clinic visit. The C-19ASS was significantly higher in female patients, those older than 70 years and those with mobility issues. Higher C-19ASS, older age and living alone were predictors of clinic nonattendance. Conclusion: COVID-19 anxiety and fear of viral exposure could adversely affect patient adherence to clinic appointments during the pandemic. Particular attention should be provided to older patients, those who live alone and patients with impaired mobility. This is particularly relevant as hospital eye services across the world are in the process of restarting.
Illoqite-(Ce), Na2NaBaCeZnSi6O17, a new member of the nordite supergroup from Ilímaussaq alkaline complex, South Greenland.
Authors: Gulbransen Emil H. , Friis Henrik , Dal Bo Fabrice , Erambert Muriel 
Published: January 2022

AbstractThe new mineral, illoqite-(Ce), with the ideal formula Na2NaBaCeZnSi6O17, has been discovered in the Taseq Slope, Ilímaussaq Alkaline Complex, Southern Greenland. Illoqite-(Ce) occurs in a hyperalkaline ussingite vein closely related to one of the largest ussingite veins in the Ilímaussaq complex. The associated minerals are aegirine, arfvedsonite, a britholite-group mineral, epistolite, chkalovite, lueshite, Mn-rich pectolite group member and steenstrupine-(Ce). Illoqite-(Ce) crystallises as either single euhedral crystals up to 150 μm in size or radiating aggregates consisting of a few or many crystals. The aggregates are up to 200 μm in diameter. Illoqite-(Ce) can occur as scattered small groups of crystals or aggregates, but sometimes they occur in high concentrations creating clusters or bands almost completely consisting of illoqite-(Ce). The empirical formula on the basis of 17 anions is Na2.00Na1.00(Ba0.59Sr0.32Ca0.04Na0.03)Σ0.98(Ce0.68La0.31Nd0.09Pr0.04)Σ1.12(Zn0.42Fe0.34Li0.14Mn0.09)Σ0.99Si5.97O17, with the simplified formula being Na2Na(Ba,Sr)(Ce,La,Nd)(Zn,Fe,Li)Si6O17. Illoqite-(Ce) exhibits sector zoning between elements Sr and Ba. The crystal structure was determined using single-crystal X-ray diffraction data and refined toR1= 2.46% using 1902 unique reflections. Illoqite-(Ce) is orthorhombic,Pcca, witha= 14.5340(7),b= 5.2213(1),c= 19.8270(4) Å,V= 1507.25(6) Å3andZ= 4. The strongest lines of the powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are: 7.266 (79) (200), 4.688 (44) (104), 4.241 (64) (210), 3.486 (79) (114), 3.340 (52) (312), 2.986 (67) (410), 2.882 (100) (314) and 2.789 (44) (016). Illoqite-(Ce) is a new member of the nordite supergroup and is named after the Greenlandic word illoq, meaning cousin, in allusion to the mineral's close relation to nordite-(Ce).
Tire Road Friction Coefficient Estimation: Review and Research Perspectives
Authors: Wang Yan , Hu Jingyu , Wang Fa’an , Dong Haoxuan , Yan Yongjun , Ren Yanjun , Zhou Chaobin , Yin Guodong 
Published: January 2022

AbstractMany surveys on vehicle traffic safety have shown that the tire road friction coefficient (TRFC) is correlated with the probability of an accident. The probability of road accidents increases sharply on slippery road surfaces. Therefore, accurate knowledge of TRFC contributes to the optimization of driver maneuvers for further improving the safety of intelligent vehicles. A large number of researchers have employed different tools and proposed different algorithms to obtain TRFC. This work investigates these different methods that have been widely utilized to estimate TRFC. These methods are divided into three main categories: off-board sensors-based, vehicle dynamics-based, and data-driven-based methods. This review provides a comparative analysis of these methods and describes their strengths and weaknesses. Moreover, some future research directions regarding TRFC estimation are presented.
Utilization of dental services and health literacy by older seniors during the COVID-19 pandemic
Authors: Weber Sophia , Günther Elena , Hahnel Sebastian , Nitschke Ina , Rauch Angelika 
Published: January 2022

Abstract
Background
This study aimed to investigate the utilization of dental services by older seniors during the COVID-19 pandemic and to evaluate their ability of finding, understanding, and using information on COVID-19.

Methods
At the end of February 2021, a survey addressing demographic characteristics of the participants, (pain-associated) utilization of dental services, worries regarding a potential COVID-19 infection, the individual use of protective masks, and difficulties regarding the access to information on COVID-19 (by using the modified European Health Literacy Questionnaire [HLS-EU-Q16]) was developed. It was sent to all patients of the Dental Clinic of University of Leipzig who were either 75, 80, or 85 years old (n = 1228). Participation was voluntarily and anonymously; questionnaires had to be returned within six weeks, no reminders were sent.

Results
Of the 439 replies (response rate 35.7%), twelve were excluded from data extraction due to disinterest, dementia, or lack of age information. Of the older seniors, 81.5% (n = 348) had utilized at least one dental examination and 54.2% of the dentulous patients (n = 199) had attended at least one dental hygiene appointment within the past year. Up to 55.8% of all participants said it was “difficult” or “very difficult” to find, understand, and use information on COVID-19, especially when judging reliability of information presented in the media, which was especially true for seniors with assigned care levels presenting odds ratios up to 5.30.

Conclusions
The investigation revealed a frequent utilization of dental services by older seniors during the COVID-19 pandemic. However, the older seniors encountered difficulties finding, using, and understanding information about COVID-19.
Identification of key genes in pathogenesis of placental insufficiency intrauterine growth restriction
Authors: Zhang Chunhua , Ding Jiao , Li Hong , Wang Ting 
Published: January 2022

Abstract
Background
Intrauterine growth restriction (IUGR) is defined as a fetus that fails to achieve its genetically determined growth potential. The exact molecular mechanisms of placental insufficiency IUGR pathogenesis are a little known. Our goal was to identify key genes and gene co-expression modules related to placental insufficiency IUGR.

Methods
We used weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis to examine the IUGR dataset GSE114691 from NCBI Gene Expression Omnibus. Core modules and hub nodes of the protein-protein interaction network were identified. A gene network was constructed and genes were classified by WGCNA into different modules. The validation of potential key genes was carried out using additional datasets (GSE12216 and GSE24129).

Results
We identified in GSE114691 539 down regulated genes and 751 up regulated genes in placental tissues characteristic of placental insufficiency IUGR compared with non-IUGR, and defined 76 genes as hub nodes in the protein-protein interaction network. Genes in the key modules of the WGCNA network were most closely associated with placental insufficiency IUGR and significantly enriched in biological process such as cellular metabolic process and macromolecule metabolic process. We identified as key genes TGFB1, LEP, ENG, ITGA5, STAT5A, LYN, GATA3, FPR1, TGFB2, CEBPB, KLF4, FLT1, and PNPLA2. The RNA expression levels of ENG and LEP, as biomarkers, were validated.

Conclusion
A holistic gene expression profile of placental insufficiency IUGR has been generated and the key genes ENG and LEP has potential to serve as circulating diagnosis biomarkers and therapeutic targets for placental insufficiency IUGR.
The nursing care of people with class III obesity in an acute care setting: a scoping review
Authors: Ewens Beverley , Kemp Vivien , Towell-Barnard Amanda , Whitehead Lisa 
Published: January 2022

Abstract
Background
Patients with Class III obesity pose unique challenges to health care staff and organisations. Care requirements of this population are unique and require specialised equipment and knowledge to meet these needs, maintain the quality of care, as well as the safety of patients and staff.

Aim
To synthesise the evidence on the nursing care of Class III obese patients in acute care settings.

Methods
A scoping review informed by JBI. CINAHL Plus, Medline, Scopus, Proquest Central, Web of Science and Embase were searched for primary research articles about the nursing management of people classified as Class III obese in acute care. Methodological quality of included studies was assessed; data extracted and synthesised into themes.

Results
Fourteen studies were included in the review. The synthesis generated three themes: Access to equipment, knowledge and training, patient care, and opportunities to improve care.

Conclusions
A paucity of high-quality evidence informs the nursing care of people with Class III obesity in acute care. Access to appropriate equipment dominated the findings of this review. Adequate provision of equipment and education on its use are required. Education to promote engagement with patients, adapting clinical practice and promotion of self-care could improve care and outcomes.
Difference in the foot intersegmental coordination pattern between female lacrosse players with and without a history of medial Tibial stress syndrome; a cross‐sectional study
Authors: Akuzawa Hiroshi , Oshikawa Tomoki , Nakamura Koji , Kubota Ren , Takaki Norifumi , Matsunaga Naoto , Kaneoka Koji 
Published: January 2022

AbstractBackgroundMedial tibial stress syndrome is a common sports related injury. Altered foot kinematics can be a risk factor for the injury. Since foot segments can move independently, intersegment coordination is important for proper foot function. This study aimed to compare the foot intersegmental coordination pattern and single segment kinematics between female lacrosse players with and without a history of medial tibial stress syndrome during drop jump.MethodsTwelve players with a medial tibial stress syndrome history and 12 players with no history were enrolled. Foot kinematics, including angle at landing and peak angle and excursion at the rearfoot, midfoot, and forefoot during single‐leg drop jumps were analysed. Each segment motion data from landing to leaping was time‐scaled to 100% to analyse the intersegmental coordination with a modified vector coding technique. Instant intersegmental coordination of every 1% was classified into four patterns (in‐phase, two segments rotate in the same direction with similar amplitudes; anti‐phase, two segments rotate in opposite directions; proximal phase, proximal segment dominantly rotates in the same direction compared to the distal segment; and distal phase, distal segment dominantly rotates in the same direction compared to the proximal segment). The percentage of intersegmental coordination pattern and kinematics in each segment were compared between the groups using the Student's t test.ResultsGroups with a history of medial stress syndrome showed a significantly higher percentage of proximal phase between the rearfoot and midfoot in the sagittal (Mean ± SD; history, 52.2 ± 17.9%, no history, 29.3 ± 16.7%; p = 0.004) and coronal planes (history, 40.3 ± 22.0%, no history, 15.9 ± 9.1%; p = 0.004). Dorsiflexion excursion (history, 34.5 ± 4.5°, no history, 29.6 ± 2.1°; p = 0.003) were significantly larger in a history of medial tibial stress syndrome group compared to no history group.ConclusionsRearfoot dominant motion pattern relative to the midfoot may be related to medial tibial stress syndrome. Intersegmental coordination analysis may be useful for detecting abnormal foot coordination patterns. Also, stabilization for the rearfoot may be required rather than the midfoot for intervention.
Diagnostic significance of serum FGD5-AS1 and its predictive value for the development of cardiovascular diseases in patients with type 2 diabetes
Authors: Wang Yongdi , Wang Jian 
Published: January 2022

Abstract
Background
As a result of the continuous rise in the incidence of type 2 diabetes mellitus (T2DM), related cardiovascular diseases (CVDs) have been a main healthy burden worldwide. This study aimed to investigate the potential role of FGD5-AS1 as a biomarker for the diagnosis of T2DM and predicting cardiovascular complications in T2DM.

Methods
Three hundred subjects were recruited in this study, including 100 T2DM patients without CVDs, 100 T2DM patients with CVDs as well as 100 healthy subjects. Plasma FGD5-AS1 level was quantified using RT-qPCR assay. The correlation of FGD5-AS1 level with other key variables was assessed using Pearson correlation analysis. ROC curve analysis was performed to evaluate the diagnostic value of FGD5-AS1 for T2DM and related CVDs. The effect of FGD5-AS1 on AC16 and HA-VSMCs was determined.

Results
FGD5-AS1 level showed a stepwise decrease in individuals with T2DM and CVDs compared to healthy persons. FGD5-AS1 was associated with BMI, systolic blood pressure, diastolic blood pressure, fasting glucose, 2-h postprandial blood glucose, HbA1c, triglycerides, usCRP, and HDL-cholesterol. The ROC analysis indicated FGD5-AS1 had a significant overall predictive ability to diagnose T2DM, T2DM with CVDs, and the combination of both. FGD5-AS1 increases the growth but alleviates apoptosis and fibrosis of high glucose-induced AC16 cells. FGD5-AS1 attenuate the growth and calcification but induced apoptosis of high glucose-treated HA-VSMC cells.

Conclusions
These results suggest that FGD5-AS1 are associated with T2DM and measuring FGD5-AS1 could potentially contribute to T2DM screening and prediction for risk of cardiovascular complication.
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors: Gao Tao , Wilkins John T. , Zheng Yinan , Joyce Brian T. , Jacobs David R. , Schreiner Pamela J. , Horvath Steve , Greenland Philip , Lloyd-Jones Donald , Hou Lifang 
Published: January 2022

Abstract
Background
GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and GAA in midlife are unknown. Also, it is unknown whether GAA mediates the associations between lipid levels in young adults and subclinical atherosclerosis in midlife.

Results
We estimated measures of epigenetic age acceleration in 1118 White and Black participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at examination years (Y) 15 and 20. We used multivariable regression models to examine associations of Y15 and Y20 GAA estimates with plasma lipid levels measured at prior examination years (Y0, Y5, and Y10) and concurrently: triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels. Mediation analysis was used to assess the extent to which GAA may mediate associations between plasma lipids and coronary artery calcification (CAC). In our study each 1-SD higher cumulative TG level was associated with an average 0.73 ± 0.12 years older GAA. Each 1-SD higher cumulative HDL-C level was associated with an average 0.57 ± 0.17 years younger GAA. Stratified analyses showed that the associations between TG and GAA were stronger among female and Black participants and the associations between HDL-C and GAA were stronger among female and White participants. GAA statistically mediated 17.4% of the association of cumulative TG with CAC.

Conclusions
High TG and low HDL-C in early adulthood are associated with accelerated epigenetic aging by midlife. Increased epigenetic age acceleration may partially mediate the associations between high TG levels and the presence of subclinical atherosclerosis.