bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
Authors: Lourdesamy Anthony Albert Iruthiaraj , Satnam Singh Taranjit Kaur , Ng Khai Lip , Abdul Rahaman Jamalul Azizi 
Published: June 2022

AbstractInflammatory myofibroblastic tumour (IMT) is an unusual myofibroblastic spindle cell neoplasm that is rarely discovered in the airway of adults. Previously, it was regarded as a reactive lesion and was infamously known as inflammatory pseudotumour before recent insights revealed that significant majority of cases harboured neoplastic genes. Diagnosis is difficult as clinical presentation and imaging findings are non‐specific. Diagnosis and a favourable prognosis require the complete resection of the tumour. Detection of the anaplastic lymphoma kinase expression via immunohistochemistry expedites diagnosis. We report a young adult with an endotracheal mass occluding the central airway. The patient successfully underwent bronchoscopic resection using interventional techniques. IMT was diagnosed. No recurrence was seen after a year of surveillance. Due to the rarity of the disease, the recurrence rates for large airway disease is unknown. Recurrence rates for pulmonary lesions is reported to be lower compared to extrapulmonary IMTs and recurrence is unlikely if compete surgical excision is achieved.
Scientific argumentation and responsive teaching: Using dialog to teach science in three middle‐school classrooms
Authors: Felton Mark , Levin Daniel M. , De La Paz Susan , Butler Cameron 
Published: June 2022

AbstractDespite broad consensus on the value of classroom dialog for promoting scientific argumentation, tensions have emerged in the literature regarding the degree to which teachers should guide the dialogic process (dialogic stance). We use the lens of responsive teaching to examine how one teacher adjusts his instruction to foster dialog in three middle‐school science classrooms. Applying grounded theory to classroom dialogs and teacher interview data, we examine the dynamic interplay of the teacher's overarching goal and moment‐to‐moment pedagogical aims to understand shifts in his dialogic stance. Our findings illustrate the value of foregrounding responsiveness to students' disciplinary thinking when offering guidance to teachers about when and how to support students in peer‐based argumentative dialog.
Do open innovation practices in firms promote sustainability?
Authors: Milana Evita , Ulrich Frank 
Published: June 2022

AbstractInnovative technologies hold the promise of a sustainable future. There is tremendous need for innovations that not only create new technologies, but also solve grand challenges this planet faces. The urgent demand for technologies spilling over sustainable values requires innovation that is open and collaborative. However, uncertainty remains whether open innovation actually promotes sustainability. We thus examine a novel perspective on the relationship between open innovation and sustainable value creation at a firm level. We ask whether inbound innovation practices such as university–industry collaboration and intellectual property in‐licensing in alignment with firm internal R&D foster sustainability.By applying a multilinear regression model on a sample of Danish firms, we found a positive effect on sustainability when firms innovate based on in‐license IP from other firms. But we did not find any correlation between university–industry collaboration and sustainability; however, it turned into a significant negative moderation effect when the firm size was added. Therefore, we conclude that smaller firms are more prompt to develop sustainable technologies, and university entrepreneurship could be a very important impetus for sustainable innovations. We also proved that firm internal R&D activities and development of radical innovations are significant predictors for sustainability. Thus, we conclude that inbound open innovation practices only partly contribute to sustainable value creation. Therefore, we suggest that combination of internal R&D with IP in‐licensing and streaming for radical innovation, whether internally developed or in‐licensed, should become embedded in the firms'' efforts for sustainability.
Can non‐developers learn a simplified modeling notation quickly?
Authors: Cervantes‐Ojeda Jorge , Gómez‐Fuentes María , Chacón‐Acosta Guillermo 
Published: June 2022

AbstractThe User Interface Transition Diagram (UITD) is a simplified modeling notation to describe the transitions between the UIs of a software system. It is designed to be used for customer‐developer s improving the models. This study investigates (i) which concepts of the UITD language are easy to understand and which ones require more effort to be understood and (ii) to what extent UITD comprehensibility depends on the user's programming skill level. A questionnaire was applied to a group of 334 non‐developers after they received a very brief explanation of the UITD concepts. The results were analyzed using statistical methods. The overall average score of the group was 70.42%, which is quite acceptable considering the briefness of the explanation. We observed a very low correlation between the subjects' programming skill level and their scores. This suggests that, even for people who have little or no programming skills, the entirety of the UITD symbols and concepts should quickly be understood with little further training.
Gas chromatography‐mass spectrometry in assessment of road run‐off sediment quality parameters
Authors: Koljančić Nemanja , Samelak Ivan , Balaban Milica , Špánik Ivan 
Published: June 2022

AbstractSurface sediment samples were collected in the Banja Luka city area, near heavy traffic roads and the Vrbas river basin, in order to determine the origin of the organic substance. For this purpose, soluble organic substances were extracted by the Soxhlet method, and extracts were fractionated by the method of column chromatography into a group of saturated hydrocarbons, aromatic hydrocarbons, and polar compounds. The total amount of soluble organic substance was in the range of 1185–3050 μg/kg. Fractions were analyzed by gas chromatography‐mass spectrometry method using a non‐polar HP‐5 ms stationary phase with a He 99.999% flow rate of 1 ml/min. Based on the chromatograms characteristic for n‐alkanes m/z 71, steranes m/z 217, and terpenes m/z 191, the specific n‐alkanes range was determined (n‐C14–n‐C39). n‐Alkanes domination of odd/even C‐number and carbon preference index values ranged from 1.12–2.48. The calculated parameters showed that the organic substance in the samples is of sedimentary origin with a significant anthropogenic input. In addition, based on the analysis of aromatic fractions and the detected unresolved complex mixture, the microbiological degradation of organic substance was determined.
Does housing policy impact income sorting near urban amenities? Evidence from Vienna, Austria
Authors: Morawetz Ulrich B. , Klaiber H. Allen 
Published: June 2022

AbstractLocal amenities capitalize into housing values and form the foundation for income and preference-based sorting of residents into communities. Ellickson’s single-crossing property establishes how household sorting leads to correlation between income and preferences for amenities. For amenities including urban green, metro stations and centrality, income-based sorting describes the process by which higher-income residents choose to locate in close proximity to higher levels of amenities. Using Vienna as an example, we empirically investigate the role housing policies have on this expected pattern of sorting. We find that the provision of municipality housing and capped rents reduces income gradients between block groups adjacent to amenities and those further away while we do not find a significant effect associated with limited-profit housing. For policymakers, this suggests that policy design plays a critical role in ensuring availability of local amenities across income groups while simultaneously confirming the single-crossing result holds despite the existence of significant market regulations.
Geschlechts-, alters- und störungsgruppenbezogene Messinvarianz bei Bindungsinstrumenten
Authors: Altmann Uwe , Flemming Eva , Lübke Laura , Spitzer Carsten , Petrowski Katja , Strauß Bernhard 
Published: June 2022

ZusammenfassungGeschlechtsunterschiede in Bindungsmerkmalen wurden bislang wenig explizit berücksichtigt. Die vorliegende Studie widmet sich dieser Thematik, einschließlich der Vergleiche von unterschiedlichen Altersgruppen sowie von klinischen und nichtklinischen Teilstichproben. Es handelt sich um die Reanalyse von 4 Datensätzen – jeweils einer Repräsentativstichprobe, einer methodenorientierten klinischen Bindungsstudie, den Stichproben des SOPHO-Net-Projekts und einer klinischen Stichprobe des Fachklinikum Tiefenbrunn –, die mithilfe der 8‑Item-Version des Experiences in Close Relationships Questionnaire (ECR-RD8) erhoben wurden. Neben den Gruppenvergleichen sollen die Daten zur Prüfung der Messsinvarianz (konfigural, metrisch, skalar) für Alter, Geschlecht und Gruppenzugehörigkeit dienen. Die Analysen zeigen, dass für Geschlecht und Alter eine komplette Messinvarianz feststellbar war, bezüglich des Patientenstatus allerdings nur eine metrische Messinvarianz. In Übereinstimmung mit einer vorliegenden Metaanalyse äußerten Frauen mehr Bindungsangst als Männer, Altersunterschiede deuten auf weniger Bindungsangst im höheren Lebensalter hin, speziell die jüngeren Personen (14 bis 24 Jahre) waren bindungsvermeidender.
The immunology of Parkinson’s disease
Authors: Zhu Biqing , Yin Dominic , Zhao Hongyu , Zhang Le 
Published: June 2022

AbstractParkinson’s disease (PD) is the second most common neurodegenerative disorder which affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies and Lewy neurites caused by α-synuclein aggregation, and neuroinflammation in the brain. The prodromal phase happens years before the onset of PD during which time many patients show gastro-intestinal symptoms. These symptoms are in support of Braak’s theory and model where pathological α‐synuclein propagates from the gut to the brain. Importantly, immune responses play a determinant role in the pathogenesis of Parkinson’s disease. The innate immune responses triggered by microglia can cause neuronal death and disease progression. In addition, T cells infiltrate into the brains of PD patients and become involved in the adaptive immune responses. Interestingly, α‐synuclein is associated with both innate and adaptive immune responses by directly interacting with microglia and T cells. Here, we give a detailed review of the immunobiology of Parkinson’s disease, focusing on the role α-synuclein in the gut-brain axis hypothesis, the innate and adaptive immune responses involved in the disease, and current treatments.
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium
Authors: Gencer Selin , Döring Yvonne , Jansen Yvonne , Bayasgalan Soyolmaa , Yan Yi , Bianchini Mariaelvy , Cimen Ismail , Müller Madeleine , Peters Linsey J. F. , Megens Remco T. A. , von Hundelshausen Philipp , Duchene Johan , Lemnitzer Patricia , Soehnlein Oliver , Weber Christian , van der Vorst Emiel P. C. 
Published: June 2022

AbstractAtherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a large residual risk; therefore, novel therapeutic candidates targeting inflammation are needed. The endothelium is the starting point of vascular inflammation underlying atherosclerosis and we could previously demonstrate that the chemokine axis CXCL12–CXCR4 plays an important role in disease development. However, the role of ACKR3, the alternative and higher affinity receptor for CXCL12 remained to be elucidated. We studied the role of arterial ACKR3 in atherosclerosis using western diet-fed Apoe−/− mice lacking Ackr3 in arterial endothelial as well as smooth muscle cells. We show for the first time that arterial endothelial deficiency of ACKR3 attenuates atherosclerosis as a result of diminished arterial adhesion as well as invasion of immune cells. ACKR3 silencing in inflamed human coronary artery endothelial cells decreased adhesion molecule expression, establishing an initial human validation of ACKR3’s role in endothelial adhesion. Concomitantly, ACKR3 silencing downregulated key mediators in the MAPK pathway, such as ERK1/2, as well as the phosphorylation of the NF-kB p65 subunit. Endothelial cells in atherosclerotic lesions also revealed decreased phospho-NF-kB p65 expression in ACKR3-deficient mice. Lack of smooth muscle cell-specific as well as hematopoietic ACKR3 did not impact atherosclerosis in mice. Collectively, our findings indicate that arterial endothelial ACKR3 fuels atherosclerosis by mediating endothelium-immune cell adhesion, most likely through inflammatory MAPK and NF-kB pathways.
Retrospective analysis of congenital nasolacrimal duct obstruction outcomes in a tertiary referral center
Authors: Told Reinhard , Pichler Anja , Lackner Birgit , Kuchar Andreas , Schmidt-Erfurth Ursula , Dunavölgyi Roman 
Published: June 2022

Summary
Background
The aim of this study was to profile patients with simple and complex congenital nasolacrimal duct obstruction (CNLDO) and to determine the success rates of interventions at a third-level referral center.

Methods
In this retrospective and comparative study, medical records of patients with CNLDO were reviewed. Demographic data, types of CNLDO, surgical approach, type of silicone intubation, as well as outcome were recorded up to 3 months after the intervention. Obstruction location was identified by probing and irrigation following the American Academy of Ophthalmology (AAO) approach. Success rates were calculated for treatment approach and age group.

Results
Based on the outcome of 130 eyes with CNLDO, the overall success rate was 96%. The mean age of patients was 2.5 ± 2.2 months; 73% of cases were simple and 27% were complex CNLDO. Five children had to undergo reoperation; consequently, there was a lower success rate in the complex CNLDO (91%) than in the simple CNLDO subgroup (97%). There was a male predominance (61.5%), which was also present in the simple and complex CNLDO subgroups. The most frequent type of CNLDO was complete nasolacrimal duct obstruction (NLDO, 55.4%), followed by partial (17.7%) and bony NLDO (11.5%). In 87% of eyes, initial probing was performed followed by dacryocystorhinostomy (10%). Mono- or bi-canalicular lacrimal drainage system intubation was used in 86% of eyes.

Conclusion
The AAO-based diagnostic approach followed by an individualized treatment regimen yielded excellent success rates of 96% in unselected patients with CNLDO. These success rates were independent of patient age or gender.
Microbiota analysis of peri-implant mucositis in patients with periodontitis history
Authors: Zhou Na , Huang Haohao , Liu Hui , Li Qiang , Yang Guangwen , Zhang Yu , Ding Meng , Dong Heng , Mou Yongbin 
Published: June 2022

AbstractObjectivesTo investigate the bacterial diversity in peri-implant plaques and the effect of periodontitis history on the occurrence of peri-implant mucositis.Materials and methodsThree groups of subgingival plaques were collected from peri-implant sulci in the first molar area. The three groups included healthy implants in patients without periodontitis (NH implant), healthy implants in patients with periodontitis history (PH implant), and peri-implant mucositis implants in patients with periodontitis history (PM implant). Subgingival plaques in periodontal pockets of contralateral natural first molars were also collected. Bacterial DNA was extracted and the V4 region of the 16S rDNA sequence was amplified and sequenced on an Illumina HiSeq platform. The operational taxonomic units obtained from amplicon sequencing were used to analyze the prevalence and identity of bacteria based on public databases and advanced techniques.ResultsAnalysis of similarities indicated a significant difference in bacterial structures between the NH implant and PM implant groups. Additionally, a significantly higher relative abundance of the generaActinomycesandStreptococcuswas found in the samples of the NH implant group. The generaFusobacteriumandPrevotellacould be considered as potential biomarkers for peri-implant mucositis. Moreover, more gram-negative anaerobic bacteria (PorphyromonasandPrevotella) were detected in the samples from patients with periodontitis history.ConclusionsThe increased accumulation ofFusobacteriumandPrevotellais associated with a higher risk of peri-implant mucositis. In addition, patients with periodontal history may be more likely to develop peri-implant mucositis.Clinical relevanceThe increase in periodontal pathogens and the decrease in health-associated bacteria in patients with periodontitis history may be more likely to develop peri-implant mucositis. These results provide a bacteriological basis for the prevention and treatment of peri-implant mucositis in patients with periodontitis history.
Sex influences clinical phenotype in frontotemporal dementia
Authors: Pengo Marta , Alberici Antonella , Libri Ilenia , Benussi Alberto , Gadola Yasmine , Ashton Nicholas J. , Zetterberg Henrik , Blennow Kaj , Borroni Barbara 
Published: June 2022

Abstract
Introduction
Frontotemporal dementia (FTD) encompasses a wide spectrum of genetic, clinical, and histological findings. Sex is emerging as a potential biological variable influencing FTD heterogeneity; however, only a few studies explored this issue with nonconclusive results.

Objective
To estimate the role of sex in a single-center large cohort of FTD patients.

Methods
Five hundred thirty-one FTD patients were consecutively enrolled. Demographic, clinical, and neuropsychological features, survival rate, and serum neurofilament light (NfL) concentration were determined and compared between sex.

Results
The behavioral variant of FTD was more common in men, whereas primary progressive aphasia was overrepresented in women (p < 0.001). While global cognitive impairment was comparable, females had a more severe cognitive impairment, namely in Trail Making Test parts A and B (p = 0.003), semantic fluency (p = 0.03), Short Story Recall Test (p = 0.003), and the copy of Rey Complex Figure (p = 0.005). On the other hand, men exhibited more personality/behavioral symptoms (Frontal Behavior Inventory [FBI] AB, p = 0.003), displaying higher scores in positive FBI subscales (FBI B, p < 0.001). In particular, apathy (p = 0.02), irritability (p = 0.006), poor judgment (p = 0.033), aggressivity (p = 0.008), and hypersexuality (p = 0.006) were more common in men, after correction for disease severity. NfL concentration and survival were not statistically different between men and women (p = 0.167 and p = 0.645, respectively).

Discussion
The present study demonstrated that sex is a potential factor in determining FTD phenotype, while it does not influence survival. Although the pathophysiological contribution of sex in neurodegeneration is not well characterized yet, our findings highlight its role as deserving biological variable in FTD.
Developing professional expertise for safety: a learning design framework
Authors: Holdsworth Sarah , Hayes Jan , Sandri Orana , Maslen Sarah 
Published: June 2022

AbstractContinuing professional development recognises that changes in the contemporary world demand that engineering professionals continuously learn. Today’s professional landscape requires the provision for ongoing learning relevant to evolving workplace requirements. This is particularly the case for engineers working in hazardous industries who make decisions every day with significant consequences. Despite this, the safety literature has paid little attention to best practice in professional learning. There is a large literature regarding lessons to be learned from accidents. Other published studies focus on training methods such as simulation. Educator-focused approaches such as these separate learning from real day-to-day workplace contexts and the learning needs of professionals. It is increasingly recognised that professionals learn, in a way that shapes their practice, from a diverse range of activities. Learning must therefore be active, social, and situated within the sphere of professional responsibilities, contexts, and groups. This paper presents a learner-centred framework that can be used to develop professional learning for safety that is grounded in day-to-day work practices and professional context needs. The framework aims to move away from the limitations that have been found with the current professional development approaches to enhance learner-centred professional learning. The framework was developed and used in the context of engineering practices regarding safety, but, because the framework encourages learning to be designed based on workplace contexts, it is applicable across a range of training needs and professions.
Holomorphic isometric embeddings of the complex two-plane Grassmannian into quadrics
Authors: Macia Oscar , Nagatomo Yasuyuki 
Published: June 2022

AbstractThe present article studies holomorphic isometric embeddings of the complex two-plane Grassmannian into quadrics. We discuss the moduli space of these embeddings up to gauge and image equivalence using a generalisation of do Carmo–Wallach theory.
Empirical analysis of the tool support for software product lines
Authors: Horcas José Miguel , Pinto Mónica , Fuentes Lidia 
Published: June 2022

AbstractFor the last ten years, software product line (SPL) tool developers have been facing the implementation of different variability requirements and the support of SPL engineering activities demanded by emergent domains. Despite systematic literature reviews identifying the main characteristics of existing tools and the SPL activities they support, these reviews do not always help to understand if such tools provide what complex variability projects demand. This paper presents an empirical research in which we evaluate the degree of maturity of existing SPL tools focusing on their support of variability modeling characteristics and SPL engineering activities required by current application domains. We first identify the characteristics and activities that are essential for the development of SPLs by analyzing a selected sample of case studies chosen from application domains with high variability. Second, we conduct an exploratory study to analyze whether the existing tools support those characteristics and activities. We conclude that, with the current tool support, it is possible to develop a basic SPL approach. But we have also found out that these tools present several limitations when dealing with complex variability requirements demanded by emergent application domains, such as non-Boolean features or large configuration spaces. Additionally, we identify the necessity for an integrated approach with appropriate tool support to completely cover all the activities and phases of SPL engineering. To mitigate this problem, we propose different road map using the existing tools to partially or entirely support SPL engineering activities, from variability modeling to product derivation.