bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi Literatur Pemanfaatan Kulit Buah Genus Citrus sebagai Larvasida Aedes aegypti
Authors: Niken Suci Meliani Hernawan  , Sri Peni Fitrianingsih  , Fetri Lestari  
Published: September 2022

Abstract. One of the ways to control the main vector of DHF, Aedes aegypti mosquito, is by using larvicides. The use of natural larvicides is an alternative in overcoming the negative impacts of using chemical larvicides. The Citrus genus is one of the plant that can be used as natural larvicides. In addition, the Citrus genus industry produces large amounts of waste or by-products such as peels, seeds and pulp, which represent 50 % of the weight of fresh fruit, so that the use of fruit peels can be one way to treat waste. The aim of the study was to determine the larvicidal potential of fruit peels of the genus Citrus against the Aedes aegypti mosquito and the compounds that play a role in the larvicidal activity. The study was performed by systematic literature review using selected articles from reputable database that meet the inclusion and exclusion criteria. The results showed that 6 plant species from the genus Citrus had larvicidal activity against Aedes aegypti consisting of Citrus sinensis, Citrus limetta, Citrus reticulata, Citrus paradisi, Citrus aurantifolia, dan Citrus limettioides. From various studies, the essential oil microemulsion and the inclusion complex of β-cyclodextrin essential oil C. sinensis, and C. limettioides essential oil are included in the classification of active larvicides (LC50 < 50 ppm). Compounds that are believed to have a role in the larvicidal activity of Citrus fruit peels include limonene and γ-terpinen .
Abstrak. Salah satu cara pengendalian vektor utama penyakit DBD yaitu nyamuk Aedes aegypti ialah dengan larvasida. Penggunaan larvasida alami menjadi salah satu alternatif dalam mengatasi dampak negatif dari penggunaan larvasdia kimia. Genus Citrus menjadi salah satu genus tanaman yang dapat dimanfaatkan sebagai larvasida alami. Disamping itu industri genus Citrus menghasilkan limbah atau produk sampingan yang cukup besar seperti kulit biji serta ampasnya yang mewakili 50 % dari berat buah segar, sehingga pemanfaatan kulit buahnya dapat menjadi salah satu cara untuk mengolah limbah. Penelitian ini bertujuan untuk mengetahui potensi larvasida dari kulit buah genus Citrus terhadap nyamuk Aedes aegypti dan senyawa yang berperan dalam aktivitas larvasida tersebut. Metode penelitian dilakukan dengan studi literatur terhadap sejumlah artikel dari database bereputasi yang memenuhi kriteria inklusi dan eklusi. Hasil penelitian menunjukkan 6 spesies tanaman dari genus Citrus memiliki aktivitas larvasida terhadap Aedes aegypti yang terdiri dari Citrus sinensis, Citrus limetta, Citrus reticulata, Citrus paradisi, Citrus aurantifolia, dan Citrus limettioides. Dari berbagai penelitian mikroemulsi dan kompleksi -siklodekstrin minyak atsiri C. sinensis serta minyak atsiri C. limettioides termasuk dalam klasifikasi larvasida aktif (LC50 < 50 ppm). Senyawa yang diyakini memiliki peran dalam aktivitas larvasida kulit buah Citrus diantaranya ialah limonen dan -terpinen.
Kepatuhan Pengobatan Pasien Geriatri dalam Pengobatan Hipertensi di Puskesmas Cicantayan Sukabumi
Authors: Muhamad Erza Ardhana  , Fetri Lestari  , Ratu Choesrina  
Published: September 2022

Abstract. The prevalence of hypertension continues to increase with age. Hypertension can cause morbidity and mortality caused due to poor blood pressure control which can be caused due to low adherence. In geriatrics, it is common that low adherence of treatment occurs caused due to several factors. The purpose of this study was to determine the level of adherence to the treatment of geriatric patients with hypertension at the Cicantayan Sukabumi Health Center and find out the factors that can influence the low level of treatment compliance in geriatric patients. This study was conducted using the MMAS-8 Questionnaire to measure the level of treatment adherence. From the results of the study conducted, the level of adherence to the treatment of geriatric patients with hypertension at the Cicantayan Sukabumi Health Center showed a low level of adherence and there was a factors affecting low adherence in geriatric patients are cognitive condition, a history of diseases associated with cognitive function, the busyness of the patient, family support, the patient's understanding, the presence of side effects, motivation in the patient, travel conditions, availability of drugs, provision of education through counselling, and polypharmaceuticals.
Abstrak. Prevalensi hipertensi terus meningkat seiring dengan bertambahnya usia. Hipertensi dapat menyebabkan morbiditas dan mortalitas yang disebabkan karena kontrol tekanan darah yang buruk yang dapat disebabkan karena rendahnya kepatuhan. Pada geriatri umum terjadi ketidakpatuhan pengobatan yang disebabkan karena beberapa faktor. Tujuan pada penelitian ini adalah untuk mengetahui tingkat kepatuhan pengobatan pasien geriatri dengan hipertensi di Puskesmas Cicantayan Sukabumi dan mengetahui faktor yang dapat mempengaruhi rendahnya kepatuhan pada pasien geriatri. Penelitian ini dilakukan dengan menggunakan Kuesioner MMAS-8 untuk mengukur tingkat kepatuhan pengobatan. Dari hasil penelitian yang dilakukan tingkat kepatuhan pengobatan pasien geriatri dengan hipertensi di Puskesmas Cicantayan Sukabumi menunjukan tingkat kepatuhan yang rendah dan terdapat faktor yang mempengaruhi rendahnya kepatuhan pada pasien geriatri adalah kondisi kognitif, riwayat penyakit yang berhubungan dengan fungsi kognitif, kesibukan pasien, dukungan keluarga, pemahaman pasien, adanya efek samping, motivasi pada pasien, kondisi bepergian, ketersediaan obat, pemberian edukasi melalui konseling, dan polifarmasi.
Sintesis Senyawa Heksapeptida Siklik Analog Pipecolisporin (Phe--ala-Trp-Pip-Arg-Pro) sebagai Kandidat Antimalari dengan Metode Kombinasi Fase Padat dan Fase Larutan
Authors: Siti Nurhalizah  , Nety Kurniaty  
Published: September 2022

Abstract. Malaria is a parasitic disease that is still a major health problem in the world, especially in tropical and sub-tropical countries. Malaria is a health disorder that occurs when red blood cells (erythrocytes) are infected with a protozoan parasite of the genus Plasmodium which is inoculated into the host through the bite of female Anopheles mosquito. Based of previously study, one of the natural antioxidant peptides is cylic hexapeptide (Phe- -ala-Trp-Pip-Arg-Pro), which was isolated from fungus Nigrospora oryzaea which has antimalarial activity. In this study, a cylic hezapeptide analogue of pipecolisporin (Phe- -ala-Trp-Pip-Arg-Pro) has been successfully synthesized using the combination methods of solid phase and liquid phase with strategy by using a protective group Fmoc, 2-chlorotrityl chloride resin as a buffer and coupling reagents including HATU, HOAt, and DIPEA. Cylic hezapeptide analogue of pipecolisporin (Phe- -ala-Trp-Pip-Arg-Pro) compound has been formed which is characterized by mass spectrophotometer with an m/z value of 794,18. The result of the RP-HPLC analysis showed that the cylic hezapeptide analogue of pipecolisporin (Phe- -ala-Trp-Pip-Arg-Pro) compund was not pure because there were still minor peaks.
Abstrak. Malaria merupakan salah satu penyakit parasit yang masih menjadi persoalan kesehatan yang utama di dunia terutama di Negara tropis dan sub tropis. Malaria merupakan suatu gangguan kesehatan yang terjadi pada saat sel darah merah (eritrosit) terinfeksi parasit protozoa dari genus Plasmodium yang diinokulasikan ke inang melalui gigitan nyamuk Anopheles betina. Salah satu peptida antimalaria alami yang ditemukan pada penelitian sebelunnya adalah heksapeptida siklik (Pro-Leu-Pip-Trp- -ala-Iso) yang diisolisasi dari jamur NIigrospora oryzae yang memiliki aktivitas antimalaria. Pada penelitian ini heksapeptida siklik analog pipecolisporin (Phe- -ala-Trp-Pip-Arg-Pro) telah berhasil disintesis menggunakan metode kombinasi fase padat dan fase larutan dengan strategi pemakaian gugus pelindung Fmoc, penyangga yaitu resin 2-klorotritil klorida dan reagen pengkopking diantaranya HATU, HOAt, dan DIPEA. Senyawa heksapeptida siklik analog pipecolisporin (Phe- -ala-Trp-Pip-Arg-Pro) telah terbentuk dengan ditandai dengan hasil karakterisasi menggunakan spektrometer massa dengan nilai m/z 794,18. Pada hasil analisis RP-HPLC menunjukkan bahwa senyawa heksapeptida siklik analog pipecolisporin (Phe- -ala-Trp-Pip-Arg-Pro) belum murni karena masih adanya puncak-puncak minor.
Analisis Hubungan Harga Saham Bank Central Asia, Inflasi, Kurs (IDR/USD) dan BI Rate dengan Metode Vector Error Correction Model (VECM)
Authors: Moh. Wigi Destriansyah  , Sirodj Dwi Agustin Nuriani 
Published: September 2022

Abstract. One method of multivariate time series analysis is VECM. VECM is used to overcome the existence of data forms that are not stationary in the average but there is cointegration in the variables. VECM is often used in long-term econometric cases such as forecasting the movement of a stock price. The movement of a company's stock price level can be influenced by factors such as inflation, exchange Rates and the BI Rate or interest Rates in the short and long term. The banking sector is one sector that is often targeted by investors, such as shares of Bank BCA Tbk because it has a high reputation, large market capitalization, positive company performance and routine dividend distribution. This study aims to analyze the effect of the variable inflation, exchange Rate (IDR/USD) and the BI Rate on the stock price of Bank Central Asia, as well as to see the long-term relationship between these variables and predict the stock price of BBCA. The variables used in this study are Inflation, Exchange Rate (IDR/USD), BI Rate to BBCA's Stock Price from August 2016 to September 2021. The model obtained is VECM(4) with 1 rank cointegration. Inflation and Exchange Rate (IDR/USD) variables have a significant effect on changes in the value of BBCA's Stock Price in the long term. While the BI Rate variable has no significant effect on changes in the value of the BBCA Share Price in the long term.
Abstrak. Salah satu metode analisis deret waktu multivariat adalah VECM. VECM ini digunakan untuk mengatasi keberadaan bentuk data yang tidak stasioner dalam rata-rata narnun terdapat kointegrasi dalam variabelnya. VECM sering digunakan dalam kasus-kasus ekonometrika jangka panjang seperti meramalkan pergerakan suatu harga saham. Pergerakan level harga saham suatu perusahaan bisa dipengaruhi oleh faktor-faktor seperti Inflasi, Kurs dan BI Rate atau suku bunga dalam jangka waktu pendek maupun panjang. Sektor perbankan menjadi salah satu sektor yang sering diincar oleh para investor, seperti saham Bank BCA Tbk sebab memiliki reputasi tinggi, kapitalisasi pasar yang besar, kinerja perusahaan yang positif dan rutin melakukan pembagian dividen. Penelitian ini bertujuan untuk menganalisis pengaruh dari variabel Inflasi, Kurs (IDR/USD) dan BI Rate terhadap Harga Saham Bank Central Asia, serta untuk melihat hubungan jangka panjang antara variable tersebut dan meramalkan harga saham BBCA. Variabel yang digunakan dalam penelitian ini adalah Inflasi, Kurs (IDR/USD), BI Rate terhadap Harga Saham BBCA dari bulan Agustus 2016 hingga September 2021. Model yang didapatkan adalah VECM(4) dengan 1 rank kointegrasi. Variabel Inflasi dan Kurs (IDR/USD) berpengaruh secara signifikan terhadap perubahan nilai Harga Saham BBCA dalam jangka panjang. Sedangkan variabel BI Rate tidak berpengaruh secara signifikan terhadap perubahan nilai Harga Saham BBCA dalam jangka panjang.
Studi Penentuan Lokasi Alternatif Tempat Pembuangan Akhir (TPA) Sampah di Kabupaten Cianjur
Authors: Aditama Tegar , Burhanudin Hani 
Published: September 2022

Abstract. Garbage is a serious problem in Cianjur Regency. The Department of Environment (DLH) of Cianjur Regency itself is considering a new land for the Final Disposal Site (FDS). The Department of Environment (DLH) of Cianjur Regency projects that the land for the new TPA will be around 25 hectares. The Cianjur Regency Government plans 2 new TPA locations in Cikadu Subdistrict and Cikalong Kulon Subdistrict. The condition of the Pasir Sembung Final Disposal Site (FDS) is already mounting and efforts are being made to reduce the volume of waste by dredging the waste and turning the waste into a pedestal or road. Cianjur Regency only has one final disposal site for waste, namely the Pasir Sembung Final Disposal Site (FDS). This TPA has been operating since 1975. The purpose of this research is to find a new FDS location in Cianjur Regency. The method used in this research is descriptive quantitative method. Data collection techniques through observation and questionnaires. The analytical method in this study uses the overlay analysis method and the hierarchy process analysis (AHP) and uses (SNI) No.19-3241-1994 as a research reference. The results of this study are the chosen location of the TPA Garbage in Cikadu District, which is in Cikadu Village, Mekarjaya Street with an area of ​​240 Ha and Cikalong Kulon District, which is in Padajaya Village, Mariwati Street with an area of ​​4.78 Ha.
Abstrak. Sampah menjadi masalah yang serius di Kabupaten Cianjur. Dinas Lingkungan Hidup (DLH) Kabupaten Cianjur sendiri tengah mempertimbangkan lahan baru untuk Tempat Pembuangan Akhir (TPA). Pihak Dinas Lingkungan Hidup (DLH) Kabupaten Cianjur memproyeksikan lahan untuk TPA baru sekitar 25 Ha. Pemerintah Kabupaten Cianjur merencanakan 2 calon lokasi TPA yang baru di Kecamatan Cikadu dan Kecamatan Cikalong Kulon. Kondisi Tempat Pembuangan Akhir (TPA) Pasir Sembung sudah menggunung dan dilakukan upaya untuk mengurangi volume sampah dengan pengerukan sampah dan sampah tersebut menjadi alas atau jalan. Kabupaten Cianjur hanya memiliki satu tempat pembuangan akhir untuk sampah yaitu di TPA Pasir Sembung. TPA ini beroperasi sejak tahun 1975. Tujuan dari penelitian ini yaitu untuk mencari lokasi TPA yang baru di Kabupaten Cianjur. Adapun metode yang digunakan dalam peneliltian ini adalah metode kuantitatif deskriptif. Teknik pengumpulan data melalui observasi dan kuesioner. Metode analisis dalam penelitian ini menggunakan metode analisis overlay dan analisis hierarcy process (AHP) serta menggunakan (SNI) No.19-3241-1994 sebagai acuan penelitian. Hasil dari penelitian ini adalah terpilihnya lokasi TPA Sampah di Kecamatan Cikadu, yang berada di Desa Cikadu, Jalan Mekarjaya dengan luasan 240 Ha dan Kecamatan Cikalong Kulon, yang berada di Desa Padajaya, Jalan Mariwati dengan luasan 4,78 Ha.
Identifikasi Potensi Perekonomian Wilayah Sekitar Waduk Jatigede
Authors: Hazkilla Kanza Pratami  , Asyiawati Yulia 
Published: September 2022

Abstract. The concept of regional development grows due to the need for the region to develop, especially in the availability of natural resources and the increasing needs of the community in line with the increase in population. Jatigede Reservoir is the second largest reservoir in Indonesia, built by damming the Cimanuk River which is found in Sumedang Regency. Jatigede Reservoir has an area of ​​3,053.34 ha which includes 4 sub-districts and 40 villages consisting of Darmaraja District, Wado District, Jatigede District, and Jatigede District. It is stated in Regional Regulation No. 4 of 2018 concerning the RTRW of Sumedang Regency article 42 paragraph 2 letter b as referred to which states that the Jatigede Reservoir is included in the KSK from the point of view of economic growth. The purpose of this study is to determine the potential that can be developed in the area around the Jatigede Reservoir. This study uses a quantitative approach, using regional economic analysis methods, namely, basic economic analysis (LQ), shift share analysis, and Klassen typology analysis. The economy of the area around the Jatigede Reservoir is still quite low. Then the results of the regional economic analysis are obtained, which are obtained from the Klassen typology analysis which produces coffee plantation commodities that can be developed in the area around the Jatigede Reservoir.
Abstrak. Konsep pengembangan wilayah tumbuh dikarenakan adanya kebutuhan wilayah untuk berkembang terutama pada ketersediaan sumber daya alam dan adanya kebutuhan masyarakat yang semakin meningkat sejalan dengan adanya pertambahan jumlah penduduk. Waduk Jatigede merupakan waduk terbesar kedua di Indonesia, dibangun dengan membendung aliran sungai cimanuk yang terdapai di Kabupaten Sumedang. Waduk Jatigede memiliki luas sebesar 3.053,34 ha yang mencakup 4 kecamatan dan 40 desa terdiri dari Kecamatan Darmaraja, Kecamatan Wado, Kecamatan Jatinunggal, dan Kecamatan Jatigede. Tercantum dalam Peraturan Daerah No 4 tahun 2018 tentang RTRW Kabupaten Sumedang pasal 42 ayat 2 huruf b sebagaimana dimaksud menyebutkan bahwa Waduk Jatigede termasuk kedalam KSK sudut kepentingan pertumbuhan ekonomi. Tujuan dalam penelitian ini yaitu, untuk mengetahui potensi yang dapat dikembangkan di wilayah sekitar Waduk Jatigede. Penelitian ini menggunakan pendekatan kuantitatif, dengan menggunakan metode analisis ekonomi wilayah yaitu, analisis ekonomi basis (LQ), analisis shift share, dan analisis tipologi klassen. Ekonomi wilayah sekitar Waduk Jatigede masih terbilang cukup rendah. Maka didapatkan hasil analisis ekonomi wilayah, yang didapat dari analisis tipologi klassen yang menghasilkan komoditi perkebunan kopi dapat dikembangkan di wilayah sekitar Waduk Jatigede.
Analisis Willingness to Pay Dan Ability to Pay dalam Berlangganan Air Bersih di Desa Cikeruh
Authors: Aghnia Thoyibah  , Burhanudin Hani 
Published: September 2022

Abstract. Getting optimal clean water is cultivated from good management sources, this is of course the community must be willing to pay household expenses to get good clean water. Many people in Cikeruh Village still use groundwater or wells that are not good if used continuously. The purpose of this study was to determine how much willingness (WTP) and ability (ATP) of the people who have not subscribed to piped clean water connections to pay the tariff determined by PDAM Tirta Medal. The analytical method used is quantitative method with Willingness to Pay (WTP) and Ability to Pay (ATP) analysis. In conclusion, 26% of respondents want to subscribe to PDAM with a willingness to pay the tariff for clean water per m3 at most willing to pay Rp. 2,750/m3 of the tariff price issued by PDAM of Rp. 2.750/m3 for the minimum tariff and Rp. 4.800/m3. m3 for the maximum rate. Meanwhile, from ATP calculations, the value of the community's ability to pay for a PDAM subscription is Rp. 4.277/m3 is close to the maximum tariff issued by PDAM.
Abstrak. Mendapatkan air bersih yang optimal diusahakan dari sumber pengelolaan yang baik, hal ini tentu masyarakat harus rela untuk membayar pengeluaran rumah tangga untuk mendapatkan air bersih yang baik. Masyarakat Desa Cikeruh masih banyak yang mengguna air tanah atau sumur yang tidak baik jika dipergunakan secara terus menerus. Tujuan dalam penelitian ini adalah mengetahui seberapa besar kemauan (WTP) dan kemampuan (ATP) masyarakat yang belum berlanggananan sambungan air bersih perpipan dalam membayar tarif yang telah ditentukan oleh PDAM Tirta Medal. Metode analisis yang digunakan adalah metode kuantitatif dengan analisis Willingness to Pay (WTP) dan Ability to Pay (ATP). Hasil kesimpulan didapatkan 26% responden mau berlangganan PDAM dengan kemauan membayar tarif air bersih per m3 paling banyak bersedia membayar sebesar ≤Rp2.750/m3 dari harga tarif yang dikeluarkan pihak PDAM sebesar Rp2.750/m3 untuk tarif paling minimum dan Rp.4.800/m3 untuk tarif paling maksimum. Sementara dari hasil perhitungan ATP didapat nilai kemampuan membayar masyarakat dalam berlangganan PDAM sebesar Rp.4.277/m3 mendekati harga tarif maksimum yang di keluarkan oleh pihak PDAM.
Detection of BRAF Gene in Some Iraqi Bowel Inflammation and Colorectal Cancer Patients
Authors: AL Musawi Ibtisam Hammood Naser , Mahood Wafaa Sabri , Jawad Mohammed Mahdi , Jawad Asmaa Ali 
Published: September 2022

The impacts of the inflammatory process on neoplasia development were observed in many cancer, it has a great role in the etiology, development and progression of invasive colorectal tumors. This study was designed to investigate the BRAF mutation and assist the clinicopathological parameter in some Iraqi bowel inflammation and colorectal cancer patients. Thirty patients were enrolled in this study (15 suffering bowel inflammation and 15 having colorectal cancer). BRAF gene was screened for the presence of mutations using PCR technique and direct sequencing. .The results revealed no BRAF mutation in position 1799 for exon fifteen in both samples of bowel inflammation and colorectal cancer. These results were confirmed previous articles regarding low rate of BRAF gene mutation in Asian countries. These results indicate the possibility of colorectal patients treatment with monoclonal antibodies. Several heterogeneity mutations were found in 3 out of 30 patients (10%) including transition two mutations G>A and one mutation was transversion mutation A>T in different sites as silent mutations
Adsorption of Bromo Phenol Red Dye from Aqueous Solution by Iraqi Bentonite Clay
Authors: Al-Dulaimy Zainab Abbas Hassan 
Published: September 2022

This studies deals with investigated the potential of a Iraqi bentonite clay for the adsorption of bromo phenol red dye from contaminated water. Impulse adsorption experiments were performed. The contact time influence of initial dye concentration, temperature, pH, ionic strength, partical size adsorbent and adsorbent dosage on bromo phenol red adsorption are investigated in a series of batch adsorption experiments. Adsorption equilibrium data were analyzed and described by the Freundlich, Langmuir and temkin isotherms equations. Thermodynamic parameters inclusive the Gibbs free energy (âˆ†Gâ€¢), enthalpy (âˆ†Hâ€¢), and entropy (âˆ†Sâ€¢), were also calculated. These parameters specified that adsorption of bromo phenol red onto bentonite was functional, more spontaneous and endothermic with increase of temperatures from 298.15 to 313.15 K.
Using of Third and Fourth Order Derivative Spectra to Simultaneous Determination of Olanzapine and Ephedrine in Its Pure and Pharmaceutical Formulations
Authors: Al-Samarrai Mumin F. Hamad , Hanoon Imad T. , Shakir Diana A. , Al-Samarrai Khalaf F. , Dikran Sarmad B. 
Published: September 2022

Two new simultaneous spectrophotometric methods for determination of Olanzapine and Ephedrine depend on third (D3) and fourth (D4) derivative of zero spectrum of two drugs were developed. The peak â€“ to- base line, peak to peak and area under peak were found proportional with concentration of the drugs up to (4-24 Âµg/ml-1) at known experimental wavelengths. The results showed that the method was precise and accurate through RSD% (0.5026-4.0273),( 0.2399 6.9888) and R.E %(-2.3889-0.8333) ,) -2.9444-0.2273) while the LOD (0.0057- 0.8510 Î¼g.ml-1), ( 0.0953-0.9844 Î¼g.ml-1) and LOQ (0.0173- 2.5788Î¼g.ml-1),( 0.5774-2.9829 Î¼g.ml-1) were found for the two drugs respectively. The methods were applied ide to the determination of Olanzapine and Ephedrine in pharmaceutical preparations successfully.