bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contents of chemokines in lacrimal fluid of the patients with diabetic retinopathy and type 2 diabetes mellitus
Authors: Agarkov N. M. , Lev I. V. 
Published: November 2022

Diabetic retinopathy is a serious microvascular complication of diabetes mellitus with chemokines playing an important pathogenetic role. However, the studies of chemokines in lacrimal fluid of the patients with diabetic retinopathy and type 2 diabetes mellitus (T2DM) are rarely performed. The aim of the study was to analyze the content of chemokines in lacrimal fluid of patients suffering from diabetic retinopathy and T2DM. When determining the concentration of chemokines in the lacrimal fluid, two clinical groups were formed: the main group of 56 elderly patients suffering from diabetic retinopathy and T2DM, and a control group of 48 age-matched persons with T2DM, however, without diabetic retinopathy. The diagnosis of diabetic retinopathy was performed after comprehensive ophthalmological examination using various modern techniques and applying the criteria of the All-Russian Association of Ophthalmologists “Diabetes mellitus: diabetic retinopathy, diabetic macular edema”. The chemokine levels in the lacrimal fluid were determined in the morning on the MAGPIX device (USA). The changed contents of chemokines was shown in lacrimal fluid of patients with diabetic retinopathy and T2DM, in comparison with patients suffering from T2DM in absence of diabetic retinopathy. In elderly patients with diabetic retinopathy and T2DM, a decreased content of GROα/ CXCL1, RANTES/CCL5 and MIP-1α/CCL3 was revealed in lacrimal fluid, at a statistically significant difference as related to controls. At the same time, the content of GROα/CXCL1 chemokine in lacrimal fluid was decreased most significantly, (38.24±2.57 in the main group versus 13.61±1.74 pg/mL in the comparison group). The level of RANTES/CCL5 decreased to 0.92±0.16 pg/mL versus 1.69±0.18 pg/mL (p < 0.001); MIP-1α/CCL3, to 2.06±0.71pg/mL versus 3.79±0.64 pg/mL, respectively. However, the proportion of chemokines in the lacrimal fluid of patients with diabetic retinopathy and T2DM was significantly inceased in all cases. This finding concerns MCP-1/CCL2, IP-10/CXCL10, and SDF1α/CXCL12. The content of IP-10/CXCL10 in lacrimal fluid increased to maximal values of 38.24±2.57 pg/mL in the patients with diabetic retinopathy and T2DM compared with 13.61±1.74 pg/mL in patients with diabetes mellitus without diabetic retinopathy, MCP-1/CCL2 to 742.34±0.89 pg/mL compared to 633.72±0.64 pg/mL, respectively; SDF1α/ CXCL12, to 264.78±7.82 pg/mL compared to 213.49±6.08 pg/mL. In addition, the interrelations between studied chemokines in patients with diabetic retinopathy and type 2 diabetes mellitus are more pronounced than in comparison group as confirmed by large number of correlations in the main group. The results obtained expand the knowledge on the effects of chemokines in lacrimal fluid upon development of diabetic retinopathy.
Management challenges of sinonasal alveolar rhabdomyosarcoma in infanthood: case report and literature review
Authors: Ayodele Samuel Oluyomi , Mohammed Bashir , Shuaib Adam 
Published: November 2022

<p class="abstract">Alveolar rhabdomyosarcoma (aRMS) is an aggressive soft tissue malignant neoplasm. It’s not known to occur often in the sinonasal region of an infant when compared with other histological types. And due to its aggressive nature in deep-seated locations, it’s often difficult to manage efficiently, thus associated with worse prognosis. In this article, a rare case of an infant with right sided sinonasal aRMS was reported. Eight month old child with two month history of right sided nasal blockage, watery discharge and a growth in the right nose. There was no epistaxis, palatal or neck swelling. On examination, a polypoid mass was completely occupying the right nasal cavity. There were no palpable cervical lymph nodes. Diagnosis of allergic rhinosinusitis with nasal polyposis was made. The mass progressed with associated ipsilateral cheek swelling extending to the nasal bridge. A greyish white, friable mass was biopsied and was diagnosed histologically as aRMS. The child had a debulking surgery and adjuvant chemotherapy. She later developed tumour lysis syndrome and died. Management of infanthood sinonasal aRMS is challenging especially in low socioeconomic region like ours. A multi-disciplinary approach with intensified multimodality therapy is crucial to improving the management outcomes and quality of life. In all, it is advisable to take closer look at any swelling in the paediatric age group by carefully evaluating it with high degree of suspicion, early diagnosis and individualized treatment.</p><p> </p>
The smoker’s larynx: a histopathological study
Authors: Munjal Manish , Garg Bhavna , Munjal Shubham , Saggar Tulika , Garg Avantika , . Arshnoor , Mehta Arnav 
Published: November 2022

<p class="abstract"><strong>Background:</strong> Larynx of chronic smokers was clinically evaluated under high powered magnification as well as on histopathology to study the effect of fumes of nicotine on the vocal cords.</p><p class="abstract"><strong>Methods:</strong> 32 chronic smokers undergoing Lewis suspension micro laryngeal surgery were selected from the laryngology clinics of Dayanand Medical College and Hospital, Ludhiana. Intraoperative findings were recorded and the specimens were sent for histopathological examination. The study was undertaken in a period of one and a half years (June 2009-December 2010). </p><p class="abstract"><strong>Results:</strong> Maximum patients 31% (10 patients) underwent microlaryngeal surgery were smokers in the middle age group (40-50 years) and minimum 9.3% (3 patients) were above 60 years of age. Vocal polyp/polypoidal change was seen in 7 (21.87%) patients was the predominant finding followed by a chronic hypertrophic change 5 (15.62%) patients. leucoplakia 4 (12.5%) cases, tubercular caseation 3 (9.3%), vocal nodules 4 (12.5%) and vocal cysts 1 (3.125%) were the other findings in our series.</p><p class="abstract"><strong>Conclusions:</strong> Nicotine fumes affect the epithelium of the vocal cord leading to hypertrophic or hyperplastic transition. Vocal cord polypoidal change, squamous cell carcinoma and chronic hypertrophic laryngitis, in that order were the lesion in our series.</p>
COMPARTILHANDO CONHECIMENTO SOBRE O NOVO CORONAVIRUS: RELATO DE EXPERIÊNCIA
Authors: Lourenço Caroline da Silva , Silva Luíza Csordas Peixinho , Bastian Mariana Sena , Sangali Leticia , Macedo Marco Antônio Durães , Salles Débora , Laviola Gabriela Marini , Leite Émerson , Lopes Juliana de Lima , Artigiani Neto Ricardo , Moraes Malinverni Andréa Cristina de 
Published: November 2022

Introdução: Em março de 2020 a OMS decretou pandemia pelo novo coronavírus (SARS-CoV-2), causador da COVID-19. Objetivo: relatar a experiência sobre a disseminação de informações sobre o coronavíus. Método: Trata-se de um relato de experiência de graduandos do curso de enfermagem e pós-graduandos em patologia, UNIFESP, na campanha Pílulas do conhecimento sobre a pandemia do novo coronavírus, realizada em março de 2020. Foi elaborado um boletim informativo e um vídeo educativo, baseado na literatura e validado por especialistas, com informações sobre o coronavírus e o material foi disponibilizado virtualmente. Resultado: O boletim informativo e o vídeo educativo foram elaborados baseados na literatura e validados por três profissionais da área da saúde. O vídeo obteve 151 visualizações no canal do Clube do Saber no YouTube e 490 pessoas no Facebook. Conclusão: A disseminação de informações sobre o coronavírus obteve grande alcance da população.
Tahfidz's Curriculum in SDIT Al-Islam Sine Ngawi Based on Boarding School
Authors: Satriyawan Aziz Nuri , Sunarso Kartika , Hanifah Fina 
Published: November 2022

The research was based on the fact that some students who did not achieve the target of Tahfidz Qur'an at the Sekolah Dasar Islam Terpadu (SDIT) Al-Islam Sine Ngawi, East Java. The purpose of this research is the implementation of Tahfidz Qur'an learning and the students’ problem in not achieving the Tahfidz Qur'an target at SDIT Al-Islam Sine Ngawi. The research implementation uses a qualitative approach with case study research. Informants in this research are students, school principals, and Tahfidz teachers. Observation, interviews, and documentation are used in collecting the data. The results of the research are first, the implementation of Tahfidz Qur'an is carried out every day after the dhuha prayer in the congregation. The implementation of Tahfidz Qur’an starts with several learning activities, they are; pre-activity, while activity and post activity which refer to lesson plan for the Tahfidz Qur'an subject. The assessment of Tahfidz Qur'an is the quantity of memorization, makrorijul hurf, and the science of recitation (tajwid). Second, the inhibiting factors that affect the inability of students in memorizing the Al-Qur'an are the different qualifications of students for memorizing the Qur'an and lack of the parental role.
La gestión catastral como mecanismo para aumentar los ingresos de las entidades territoriales por medio del cobro del impuesto predial
Authors: Verástegui Niño Elena Rocío 
Published: November 2022

La desactualización catastral en el territorio nacional introdujo la política pública del Catastro Multipropósito, que trajo consigo la descentralización de la función catastral y su consecuente configuración en servicio público, ahora prestado por entidades públicas en calidad de gestores y por particulares en condición de operadores, cuya actuación colaborativa contribuye con la recolección de la información predial en sus componentes jurídicos, físicos y económicos. Este último traducido en la determinación del avalúo catastral como base gravable del impuesto predial unificado y que genera que la actividad de actualización aumente el recaudo tributario de los municipios pese a los límites introducidos para mitigar las alzas en este impuesto y con las consecuencias que dicho aumento trae para el sujeto pasivo.
En consecuencia, el presente trabajo tiene por objeto analizar el marco regulatorio de la descentralización del catastro a partir de la introducción de los nuevos responsables de la prestación del servicio público de la gestión catastral, para lo cual se planteará el procedimiento de habilitación como requisito para ser catalogado como gestor, así como los procesos de formación, actualización, conservación y difusión que debe adelantar el prestador del servicio y a partir de estos establecer las consecuencias que tiene la implementación en el impuesto predial unificado, específicamente mirando sus componentes desde un punto de vista catastral, para finalizar concluyendo cómo la actividad del gestor catastral aumenta el pago de este impuesto.
Apocalypse . . . Eventually: Trans-Corporeality and Slow Horror in M. R. Carey’s The Girl with All the Gifts
Authors: Druzak Courtney A. 
Published: November 2022

This article examines M. R. Carey’s 2014 zombie apocalypse novel The Girl with All the Gifts through the ecofeminist concept of trans-corporeality as defined by Stacy Alaimo in Bodily Natures. Carey’s heroine Melanie showcases how humans can re-conceptualize their relationship to a more-than-human, or natural, world that is both exterior to the self and always-already a part of the self through fungal agency. Indeed, the novel continuously engages in intimate human-environment interconnections that, in their horrific capacities, are meant to inspire readers to reflect upon their own enmeshment in a larger, material world. The novel’s use of the real fungus Ophiocordyceps as the more-than-human agent that inspires the transformation of humans into zombies provides a vision for how humans can more ethically relate, in posthuman manners, to a more-than-human world. Finally, this article considers the novel as a depiction of slow horror, or a gradual descent into apocalypse.
Sympoiesis, Autopoiesis and Immunity: How to Coexist with Nonhuman Others?
Authors: Žukauskaitė Audronė 
Published: November 2022

In this essay I will discuss Donna J. Haraway’s notion of sympoiesis and examine different modes of cohabitation or hybridization with nonhuman others. Such concepts as sympoiesis, or holobiont, question the notion of the biological individual and also change our understanding of what it means to be human. As Richard Grusin pointed out, “we have never been human” because “the human has always coevolved, coexisted, or collaborated with the nonhuman—and that the human is characterized precisely by this indistinction from the nonhuman” (ix–x). We have never been human because we have always been dependent on other species living within or beyond our bodies. However, the question which still needs to be answered is whether all forms of coexistence are profitable and welcomed. How does one define the limit at which this co-existence is collaborative and productive (“posthuman”), and beyond which it becomes damaging and lethal (in other words, “posthumous,” e.g., coming after life)? For this reason, the interrelations between different life forms should be discussed together with the concepts of contagion and immunity. The notion of immunity expresses an ambivalent character of life: on the one hand, it protects the organism against everything that is beyond its boundary; on the other hand, it helps to collaborate with other organisms and to create an ecosystem. In this sense, immunity can be thought as a field of negotiations between human and nonhuman beings.
O papel da participação social na redução de riscos de desastres no Brasil
Authors: Silva Ananda Ramos da , Santos Vânia Maria Nunes dos 
Published: November 2022

O objetivo do presente trabalho foi mapear e analisar a produção científica brasileira sobre a participação social na redução de riscos de desastres para discutir seu papel na construção de uma cultura preventiva e de resiliência. A análise considerou as publicações identificadas entre o ano de 2011 e o primeiro semestre de 2022, por meio das bases de dados SciELO – Scientific Electronic Library Online, Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES e REDIB – Rede Iberoamericana de Innovación y Conocimiento Científico, utilizando os termos de indexação “mapeamento participativo” ou “mapeamento comunitário” ou “participação”, combinados com o termo “desastres”, resultando na seleção de 31 artigos para a leitura completa. As análises resultaram em um panorama sobre o ano; áreas do conhecimento e; região/estado do país e desastres abordados nas publicações. Além disso, a partir da leitura dos artigos, foi realizada a identificação dos temas, da metodologia empregada e dos resultados e discussão para que fossem constatados fatores em comum. Desse modo, a análise das produções foi realizada de acordo com três categorias temáticas baseadas em algumas das recomendações relacionadas à prioridade de ação número 1, “Compreensão do risco de desastres”, determinada pelo Marco de Sendai em 2015 “Compreensão do risco de desastres”: Análises pós-desastres; Educação e compartilhamento de saberes e; Participação social. Como principais resultados tem-se: i. o potencial de diferentes ferramentas para o fomento da participação popular na redução de riscos desastres – mapeamentos participativos, entrevistas, questionários e oficinas –; e ii. o envolvimento de diversos públicos – adolescentes, moradores de áreas de risco, poder público, pesquisadores e profissionais de diferentes áreas do conhecimento –. A partir dos elementos aqui discutidos espera-se contribuir com estudos futuros acerca desta temática para que sejam criados e promovidos instrumentos, ações e estratégias de prevenção, mitigação e resiliência a desastres que procurem engajar o maior número possível de atores sociais.
Model-free Adaptive Position Tracking Control of Induction Motors Based on Memory-based Data-driven Extended State Observers
Authors: Liu Lu , Yang Anxin , Zhang Weidong 
Published: November 2022

Abstract
This paper investigates the position control of induction motor in the presence of model uncertainties, load torque disturbances, unknown input gains, and unmeasured rotor velocity. A model-free position tracking controller is proposed based on novel memorybased data-driven extended state observers and dynamic surface control design, under which the induction motor can track the reference position without any priori knowledge of model parameters. In the observation loop, memory-based data-driven extended state observers are developed to estimate the model uncertainties, load disturbances, as well as the control input gains without the measurement of rotor velocity. The convergence of estimation errors is guaranteed without persistently exciting condition, and the true value of control input gains are reconstructed in finite-time. In the control loop, a dynamic surface controller is developed based on the proposed observers, such that the model-free position tracking control of induction motors can be achieved. The observer and controller are designed in modularity and form a cascade system, which is proved to be input-to-state stable. Simulations illustrate the effectiveness of the proposed model-free position tracking controller for induction motors.
Regional precipitation forecasting with double fuzzy inference system (DOFIS) model
Authors: Şen Zekâi 
Published: November 2022

Abstract
This paper proposes a double fuzzy inference system (DOFIS) as a way to estimate point hydrological values ​​at any desired point, based on records from easting and northing fuzzy sets. For a given set of station locations, hydrological quantities are added as fuzzy set core with a membership degree (MD) equal to one and support equal to zero MD. The application of the methodology is presented on the basis of annual precipitation amounts at 10 meteorological stations for the southeastern province of Turkey. A comparison of the methodology against the radial basis function (RBF), Kriging (KRG) and inverse distance square (IDS) interpolation techniques is presented. The mean relative error percentages for the DOFIS, RBF, KRG and IDS methods are 0.078, -7.61, -7.80 and -7.72, respectively. All are within ±10% acceptable error limits in practice. This point represents a significant improvement in spatial estimation based on the DOFIS methodology.
A novel-quantitative vulnerability evaluation method for multi-type ecological functional areas based on dynamic weight determination and NPP
Authors: Yuan Xingming , Guo Bing 
Published: November 2022

Abstract
Most precious studies focused on one single type of ecological functional area during single period, which ignored the differences of evaluation systems and index weights among different ecological areas in different study periods. In addition, the comparability of vulnerability assessment results among different study areas was poor. This paper proposed a novel-quantitative vulnerability evaluation method for multi-type and multi-temporal ecological functional areas using dynamic weighting method: Three-River Source region grassland meadow wetland ecological functional area(TRSR), Guiqiandian karst rocky desertification control ecological functional area(GQD), Hunshandake desertification control ecological functional area(HSDK), and Chuandian forest and biodiversity ecological functional area(CD), and then introduced the net primary productivity (NPP) to realize the determination of multi-type ecological vulnerability thresholds, which is helpful to compare the vulnerability evaluation results of different ecological functional areas in a unified and comparable level. The results showed that: (1) The proposed novel-quantitative vulnerability evaluation method had higher applicability in vulnerability assessment for multi-type ecological functional areas(91.1% for TRSR,91.9%for HSDK, 91.7% for CD, and 94.2% for GQD) based on dynamic weight determination method;(2) The determination of vulnerability thresholds based on NPP could provide a comparable level to investigate the spatial distribution patterns of ecological vulnerability in multi-type ecological functional areas for different periods; (3) The average ecological vulnerability of TRSR, GQD, and CD belonged to mild vulnerability, while that of HSDK belonged to moderate vulnerability; (4) There were significant differences in the dominant factors of ecological vulnerability for multi-type ecological functional areas in different periods. The research results could provide data and method supports for ecological protection for multi-type ecological zones in national scale.
Cold dispase digestion of murine lungs improves recovery and culture of airway epithelial cells
Authors: Janas Piotr P , Chauché Caroline , Shearer Patrick , Perona-Wright Georgia , McSorley Henry J , Schwarze Jürgen 
Published: November 2022

Abstract
Airway epithelial cells (AECs) play a key role in maintaining lung homeostasis, epithelium regeneration and the initiation of pulmonary immune responses. To isolate and study murine AECs investigators have classically used short and hot (1h 37°C) digestion protocols. Here, we present a workflow for efficient AECs isolation and culture, utilizing long and cold (20h 4°C) dispase II digestion of murine lungs. This protocol yields a greater number of viable AECs compared to an established 1h 37°C dispase II digestion. Using a combination of flow cytometry and immunofluorescent microscopy, we demonstrate that compared to the established method, the cold digestion allows for recovery of a 3-fold higher number of CD45−CD31−EpCAM+ cells from murine lungs. Their viability is increased compared to established protocols, they can be isolated in larger numbers by magnetic-activated cell sorting (MACS), and they result in greater numbers of KRT5+p63+ colonies in vitro, which have the capacity to proliferate. Our findings demonstrate that temperature and duration of murine lung enzymatic digestion have a considerable impact on AEC yield, viability, and proliferation in vitro. We believe this workflow will be helpful for studying lung AECs and their role in the biology of lung.
Effect of ultrasound-guided targeted needling of the cricopharyngeal muscle on post-stroke cricopharyngeal dysphagia: a prospective, multicenter, randomized controlled trial
Authors: hua xiaoqiong , Ren Kun , Jin Xiaoqin , Qin Hewei , Wang Yiying , Li Yanjie 
Published: November 2022

Abstract
BACKGROUND: Swallowing disorders are a common complication after stroke.
OBJECTIVE: The aim of this study was to evaluate the effectiveness of acupuncture of the cricopharyngeal muscle in the treatment of cricopharyngeal disorders and to explore a new method that is safe, intuitive, precise, and effective.
METHODS: This was a multicenter randomized controlled trial. One hundred and forty-eight patients with post-stroke cricopharyngeal muscle relaxation dysphagia who met the criteria at three hospitals were randomly divided into a control group (n=74) and a test group (n=74). The control group received conventional swallowing training with basic medication (including basic training and feeding training), and the test group received ultrasound-guided targeted acupuncture treatment of the cricopharyngeal muscle in addition to the treatment of the control group for 4 weeks. Patients in both groups used VFSS, WST, SSA, SWAL-QOL and EAT-10, PAS and NRS 2002 before and after treatment.
DISCUSSION: This trial used ultrasound-guided acupuncture to treat cricopharyngeal muscle loss relaxation, not only to explore a new method that is safe, intuitive, precise and effective, but also to provide more high-quality experimental evidence for the clinical application of the combination of Chinese and Western medicine.
Trial registration: China Clinical Trials Registry ChiCTR2200063337. registered on September 5, 2022.