bluuebunny/crossref_metadata_2025_split huggingface dataset:
State minimum wage increases delay marriage and reduce divorce among low‐wage households
Authors: Karney Benjamin R. , Wenger Jeffrey B. , Zaber Melanie A. , Bradbury Thomas N. 
Published: March 2022

AbstractObjectiveTo estimate the effects of state‐level changes in the minimum wage on marriage and divorce among low‐wage earners.BackgroundProponents of raising the minimum wage highlight the potential benefits of increased earnings for low‐income families, yet to date research on the effects of raising the minimum wage has focused almost exclusively on economic outcomes. No research has yet documented whether these changes actually affect marriage and divorce.MethodUsing the Current Population Survey and the American Community Survey, this project applied a quasi‐experimental difference‐in‐difference method to exploit similarities between states that have, and have not, raised their minimum wage.ResultsAcross data sources, among men and women earning low wages, a one‐dollar increase in the state minimum wage predicts a 3%–6% decline in marriage entry and a 7%–15% decline in divorce one and 2 years later.ConclusionBoth changes are likely to strengthen low‐income families, and are substantially larger effects than those obtained by federal policies directly targeting interpersonal dynamics within low‐income couples.ImplicationsGovernment policies that reduce stress on couples and facilitate their access to resources may improve family outcomes, invisibly and without making additional demands on the time of couples who are already strained.
A theoretical model on how firms can leverage political resources to align with supply chain strategy for competitive advantage
Authors: Grover Abhay K. , Dresner Martin 
Published: March 2022

AbstractThe success of a firm's supply chain strategy depends on resources in the political environment and the supply network in which it operates. If the political environment is not conducive to a firm's supply chain strategy, a firm can either change its supply chain strategy or seek a political environment that is more favorable to its supply chain. This paper examines this second alternative. The structure‐conduct‐performance (SCP) paradigm and the competitive dynamics literature are used to explore the relationships between political actions that leverage supply network resources, supply chain strategies, and firm performance. We extend a well‐known typology of political actions from the strategic management literature and suggest that beyond influencing or complying with the political environment, firms may choose to moderate the political environment (circumvent or submit) or stay neutral (free ride). An integrated model is developed to explore the relationships between political actions and supply chain strategy, along with a series of propositions outlining how political actions can facilitate supply chain risk management strategies. Finally, suggestions are provided for future research.
Ultrasound‐assisted modification of gelation properties of proteins: A review
Authors: Bangar Sneh Punia , Esua Okon Johnson , Sharma Nitya , Thirumdas Rohit 
Published: March 2022

AbstractProtein gels have diverse applications in the food, pharmaceutical, and cosmetic sectors due to their affordability, biodegradability, and edibility. However, the inherent properties of some native proteins have a few drawbacks that have to be tailored to meet the needs of specific functions as the food ingredients. The protein gelation properties mainly depend on the protein molecular structure, primarily the folding and unfolding of secondary structural elements (α‐helix and β‐sheets) with distinctive functions. In the past, a great amount of work (thermal, chemical, and enzymatic methods) has been carried out to enhance the gelation and functional properties of proteins. Recently, the traditional methods have been replaced with non‐thermal physical methods that enhance the properties for better applications. One such approach is the use of ultrasonic technology as a low‐cost green technology to modify the molecular orientation attributed to the native chemistry and functionality of that proteins. Ultrasonic technology is important in food systems and can be effectively used as an alternative method to improve the protein gelling characteristics to form high‐quality gels. This article is aimed to comprehensively collate some of the vital information published on the mechanism of protein gelation by ultrasonication and review the effects of ultrasound‐assisted extraction and treatments on gelation properties of different proteins. The enhanced gelation properties by the ultrasound application open a new stage of technology that enables the proteins for better utilization in the food processing sector.
The impact of point‐of‐care hepatitis C testing in needle and syringe exchange programs on linkage to care and treatment uptake among people who inject drugs: An Australian pilot study
Authors: Howell Jessica , Traeger Michael W. , Williams Bridget , Layton Chloe , Doyle Joseph S. , Latham Ned , Draper Bridget , Bramwell Frances , Membrey Dean , McPherson Maggie , Roney Janine , Stoové Mark , Thompson Alexander J. , Hellard Margaret E. , Pedrana Alisa 
Published: March 2022

AbstractPoint‐of‐care (POC) diagnostics overcome barriers to conventional hepatitis C (HCV) testing in people who inject drugs. This study assessed impact on hepatitis C treatment uptake of POC HCV testing in needle and syringe exchange programs (NSPs). Rapid EC was a single‐arm interventional pilot study of HCV POC testing conducted in three inner‐city community clinics with NSPs. Twelve months after the POC testing, a retrospective medical record and Pharmaceutical Benefits Scheme audit was performed to determine the number of HCV RNA‐positive participants who were prescribed HCV treatment. 70 HCV RNA‐positive Rapid EC study participants were included. 44 (63%) were prescribed DAAs; 26 (59%) completed treatment and 15 (34%) had SVR testing, all of whom were cured. Age ≥ 40 years (aOR 3.45, 95% CI 1.10–11.05, p = .03) and secondary school education (aOR 5.8, 95% CI 1.54–21.80, p = .009) had higher likelihood of being prescribed DAAs, whereas homelessness was inversely associated with prescription of DAAs (aOR 0.30, 95% CI 0.09–1.04, p = .057). Median time to receive a DAA script from date of diagnosis was seven days (IQR 0 to 14 days), and time to filling the DAA prescription was 2 days (IQR 0–12 days). In conclusion, provision of POC testing through NSPs was effective for linking new clients to HCV treatment and reduced the time to treatment. Further studies are needed to define the most cost‐effective use of POC testing in models of care for people who inject drugs to increase HCV treatment uptake.
Serum HBV RNA predicts HBeAg clearance and seroconversion in patients with chronic hepatitis B treated with nucleos(t)ide analogues
Authors: Wang Yang , Liao Hao , Deng Zhongping , Liu Yanna , Bian Dandan , Ren Yan , Yu Guangxin , Jiang Yingying , Bai Li , Liu Shuang , Liu Mei , Zhou Li , Chen Yu , Duan Zhongping , Lu Fengmin , Zheng Sujun 
Published: March 2022

AbstractThis study evaluated the predictive value of serum HBV DNA, HBV RNA, HBcrAg, HBsAg, intrahepatic HBV DNA and cccDNA for HBeAg clearance and seroconversion during long‐term treatment with nucleos(t)ide analogues (NAs) in patients with chronic hepatitis B (CHB). A single centre, prospective cohort of CHB patients was used for this study. Serum HBV RNA levels were retrospectively measured at baseline, 6, 12, 24, 36, 48, 60, 72 and 84 months post‐NAs treatment. Serum HBsAg and HBcrAg levels were quantified at baseline, month 6, 60 and 72. Histological samples from liver biopsy at baseline and month 60 were analysed for intrahepatic HBV DNA and cccDNA. Eighty‐three HBeAg‐positive patients were enrolled with a median follow‐up time of 108 months (range 18–138 months). Of them, 53 (63.86%) patients achieved HBeAg clearance, and 37 (44.58%) achieved HBeAg seroconversion. Cox multivariate analysis showed that only baseline HBV RNA was independently associated with HBeAg clearance and seroconversion (<5.45 log10copies/mL, HR = 5.06, 95% CI: 1.87–13.71, p = .001; HR = 3.38, 95% CI: 1.28–8.91, p = .01). The independent association with HBeAg clearance and seroconversion remained for HBV RNA levels at month 6 (<4.72 log10copies/mL, HR = 4.16, 95% CI: 1.61–10.72, p = .003; HR = 6.52, 95% CI: 1.85–22.94, p = .003) and month 12 (<4.08 log10 copies/mL, HR = 3.68, 95% CI: 1.96–6.90, p < .001; HR = 2.79, 95% CI: 1.31–5.94, p = .008). The AUCs of baseline HBV RNA for predicting the HBeAg clearance (0.83, 95% CI: 0.70–0.96, 0.83, 95% CI: 0.70–0.96 and 0.82, 95% CI: 0.69–0.95 respectively) and seroconversion (0.89, 95% CI: 0.77–1.00; 0.81, 95% CI: 0.66–0.95 and 0.84, 95% CI: 0.71–0.98 respectively) at month 36, 60 and 84 were higher than those of HBV DNA, HBsAg and HBcrAg. In conclusion, lower serum HBV RNA at baseline, month 6 and 12 post‐NAs treatment could predict HBeAg clearance and seroconversion during long‐term NAs treatment.
Comparison of linear and volumetric criteria for the determination of therapeutic response in dogs with intracranial gliomas
Authors: Garcia Mora Josefa Karina , Robertson John , Hsu Fang‐Chi , Shinn Richard Levon , Larson Martha M. , Rylander Christopher G. , Whitlow Christopher T. , Debinski Waldemar , Davalos Rafael V. , B. Daniel Gregory , Rossmeisl John H. 
Published: March 2022

AbstractBackgroundBrain tumor therapeutic responses can be quantified from magnetic resonance images (MRI) using 1‐ (1D) and 2‐dimensional (2D) linear and volumetric methods, but few studies in dogs compare these techniques.HypothesesLinear methods will be obtained faster, but have less agreement than volumetric measurements. Therapeutic response agreement will be highest with the total T2W tumor volumetric (TTV) method. Therapeutic response at 6‐weeks will correlate with overall survival (OS).AnimalsForty‐six dogs with intracranial gliomas.MethodsProspective study. Three raters measured tumors using 1D and 2D linear, TTV, and contrast‐enhancing volumetric (CEV) techniques on 143 brain MRI to determine agreement between methods, define therapeutic responses, and assess relations with OS.ResultsRaters performed 1D the fastest (2.9 ± 0.57 minutes) and CEV slowest (17.8 ± 6.2 minutes). Inter‐ and intraobserver agreements were excellent (intraclass correlations ≥.91) across methods. Correlations between linear (1D vs 2D; ρ > .91) and volumetric (TTV vs CEV; ρ > .73) methods were stronger than linear to volumetric comparisons (ρ range, .26‐.59). Incorporating clinical and imaging data resulted in fewer discordant therapeutic responses across methods. Dogs having partial tumor responses at 6 weeks had a lower death hazard than dogs with stable or progressive disease when assessed using 2D, CEV, and TTV (hazard ration 2.1; 95% confidence interval, 1.22‐3.63; P = .008).Conclusions and Clinical ImportanceOne‐dimensional, 2D, CEV, and TTV are comparable for determining therapeutic response. Given the simplicity, universal applicability, and superior performance of the TTV, we recommend its use to standardize glioma therapeutic response criteria.
The language of high‐stakes truths and lies: Linguistic analysis of true and deceptive statements made during sexual homicide interrogations
Authors: Thompson Andrew D. , Hartwig Maria 
Published: March 2022

AbstractPurposeFew studies have assessed deception during real‐life, high‐stakes encounters. This study is one of the largest and most geographically diverse to investigate how criminal suspects lie during investigative interviews. It is also one of the most specific; focusing solely on those who committed sexually motivated homicides.MethodsSections of transcripts from 52 sexually motivated homicide offender interrogations were analysed using Linguistic Inquiry and Word Count software. Truthful (n = 27) and deceptive (n = 25) statements, corroborated through physical evidence, were then compared using the reality monitoring (RM) model of deception.ResultsSupport for the RM model was mixed. Truthful statements contained more motion and spatial details. There were no significant differences between true and deceptive statements when comparing perceptual, affective, and cognitive process details.ConclusionsThe results support the notion that there are verbal cues to deception detectable in high‐stakes, real‐life situations. It also provides a starting point to assess these cues in special forensic populations.
Prevalence and incidence of hepatitis C infection amongst men who have sex with men in a population‐based pre‐exposure prophylaxis program in British Columbia, Canada
Authors: Thompson Kyle A. , Blank Gabriel , Toy Junine , Moore David M. , Lachowsky Nathan , Bacani Nicanor , Zhang Wendy , Sereda Paul , Lima Viviane D. , Barrios Rolando , Montaner Julio S. G. , Hull Mark W. 
Published: March 2022

AbstractBackgroundMen who have sex with men (MSM) are at risk for sexually‐transmitted hepatitis C (HCV). Evidence for HCV infection in the context of pre‐exposure prophylaxis (PrEP) use in North America is limited. We sought to characterize baseline HCV prevalence and incidence in MSM receiving PrEP in British Columbia (BC), Canada.MethodsWe followed individuals in the BC PrEP program from January 2018 to August 2019. We evaluated baseline prevalence and incident seroconversions (newly positive HCV antibody). A multivariable logistic regression model was performed in MSM for factors associated with HCV prevalence at enrollment, including reported prior sexually transmitted infection (STI), HIV Incidence Risk Index for MSM score, PrEP use because of a partner living with HIV, and location of residence.ResultsThe median age of the cohort was 33 years, 98.3% male, with 3058 person years (PY) of follow‐up. Baseline HCV prevalence was 0.82% (31/3907 MSM enrollees) and HCV incidence (n = 3) was 0.15 per 100 PY (95% confidence interval [CI] 0.03–0.45). In multivariable analysis, initiating PrEP because of a partner living with HIV (adjusted odds ratio [aOR] 5.02; 95% CI 1.87–13.47) and prior STI (aOR 2.34; 95% CI 1.04–5.24) were associated with positive HCV status.ConclusionsBaseline HCV prevalence and incidence was low amongst MSM in a population‐based PrEP program in BC, Canada. HCV was associated with bridging from populations living with HIV and evidence of a reported prior STI as a PrEP indicator condition amongst MSM. PrEP initiation may be an opportunity for linkage to HCV screening and treatment.
m5C and m6A modification of long noncoding NKILA accelerates cholangiocarcinoma progression via the miR‐582‐3p‐YAP1 axis
Authors: Zheng Haiming , Zhu Meiying , Li Wenhua , Zhou Zunqiang , Wan Xinjian 
Published: March 2022

AbstractCholangiocarcinoma (CCA) is a severe malignancy originating from the bile duct and the second most common primary liver cancer. NF‐kappa B interacting lncRNA (NKILA) is a functional lncRNA, which play important role in human cancers. However, the role and underlying mechanism of NKILA in CCA remains largely unknown. Here, our study demonstrated that NKILA was significantly upregulated in CCA tissues and cells. Overexpression of NKILA is associated with advanced TNM stage, lymph node and distant metastasis, and also indicated poor prognosis in CCA patients. Functionally, NKILA facilitated CCA growth and metastasis in vitro and in vivo. The 5‐methylcytosine (m5C) methyltransferase NSUN2 interacts with NKILA, increasing its m5C level and promoting its interaction with YBX1. Moreover, NKILA physically interacted with and suppressed miR‐582‐3p, which was regulated by METTL3‐mediated N6‐methyladenosine (m6A) modification. Finally, we showed that YAP1 was a target of NKILA via miR‐582‐3p and NKILA functioned partially via YAP1 in CCA. Taken together, our findings indicate a novel regulatory mechanism of NKILA for promoting CCA progression and that NKILA may be a promising target for CCA treatment.
Debilitated Lifeworlds: Women's Narratives of Forced Sterilization as Delinking from Reproductive Rights
Authors: Chaparro‐Buitrago Julieta 
Published: March 2022

AbstractPeasant women in Cajamarca, Peru, who were sterilized by the Peruvian government in the 1990s, narrate their experiences of reproductive abuse using Andean medical principles of debilidad and fuerza (debility and strength) (Tapias 2006). In their narratives, many describe a generalized sense of loss of strength resulting from the procedure. This contrasts with the reproductive rights framework's emphasis on infertility as the main harm. In this article, I ponder the dissonance between these two frameworks and propose the concept of debilitated lifeworlds as decolonial feminist delinking (Mignolo 2007) from human fertility‐centric narratives. This concept is methodologically significant as a decolonial attunement to local motifs to talk about abuse and for weaving a constellation of embodied, emotional, social, and family harms. This article contributes to the emerging field of “decolonial reproductive studies” (Smietana et al. 2018: 117).
Diet and food insecurity among mothers, infants, and young children in Peru before and during COVID‐19: A panel survey
Authors: Pradeilles Rebecca , Pareja Rossina , Creed‐Kanashiro Hilary M. , Griffiths Paula L. , Holdsworth Michelle , Verdezoto Nervo , Eymard‐Duvernay Sabrina , Landais Edwige , Stanley Megan , Rousham Emily K. 
Published: March 2022

AbstractThe COVID‐19 pandemic may impact diet and nutrition through increased household food insecurity, lack of access to health services, and poorer quality diets. The primary aim of this study is to assess the impact of the pandemic on dietary outcomes of mothers and their infants and young children (IYC) in low‐income urban areas of Peru. We conducted a panel study, with one survey prepandemic (n = 244) and one survey 9 months after the onset of COVID‐19 (n = 254). We assessed breastfeeding and complementary feeding indicators and maternal dietary diversity in both surveys. During COVID‐19, we assessed household food insecurity experience and economic impacts of the pandemic on livelihoods; receipt of financial or food assistance, and uptake of health services. Almost all respondents (98.0%) reported adverse economic impacts due to the pandemic and 46.9% of households were at risk of moderate or severe household food insecurity. The proportion of households receiving government food assistance nearly doubled between the two surveys (36.5%–59.5%). Dietary indicators, however, did not worsen in mothers or IYC. Positive changes included an increase in exclusive breastfeeding <6 months (24.2%–39.0%, p < 0.008) and a decrease in sweet food consumption by IYC (33.1%–18.1%, p = 0.001) and mothers (34.0%–14.6%, p < 0.001). The prevalence of sugar‐sweetened beverage consumption remained high in both mothers (97%) and IYC (78%). In sum, we found dietary indicators had not significantly worsened 9 months into the COVID‐19 pandemic. However, several indicators remain suboptimal and should be targeted in future interventions.
Dorsal fin mark changes for assigning sexes to individual bottlenose dolphins, Tursiops truncatus
Authors: James Bridget S. , Gridley Tess , McGovern Barry , Fearey Jack L. , Elwen Simon H. 
Published: March 2022

Abstract.Sexing cetaceans typically requires extended periods of observation or expensive molecular methods. An alternative approach using photo‐identification may provide a cost‐effective, noninvasive method for assigning a sex to free‐ranging individuals. We investigated two methods for predicting the sex of common bottlenose dolphins (Tursiops truncatus) from Namibia, using the rate of change in dorsal fin (1) trailing edge marks or (2) surface features (scarring and lesions) and binary logistic regression models. Our results suggest animals with frequent and extensive changes to dorsal edge marks, or a high number/proportion of the dorsal fin covered in surface features are likely male, while those with little to no changes in dorsal edge marks or low numbers/proportion of surface features are likely female. Both sex prediction models performed reasonably well (accuracy: edge marks: 100%, surface features: 83%), with a high degree of consensus between models in sex predictions (78.6%). Our models are straightforward to implement and robust for the study population, providing useful insights into individuals' sex and population demographics. This reliable, inexpensive, and minimally invasive framework for assigning sex could be widely applicable, if population‐specific information of known sex individuals is included, due to the variable social systems and behaviors exhibited by Tursiops spp.
Neuron types in the primate striatum: Stereological analysis of projection neurons and interneurons in control and parkinsonian monkeys
Authors: del Rey Natalia López‐González , Trigo‐Damas Inés , Obeso José A. , Cavada Carmen , Blesa Javier 
Published: March 2022

AbstractAimsThe striatum is mainly composed of projection neurons. It also contains interneurons, which modulate and control striatal output. The aim of the present study was to assess the percentages of projection neurons and interneuron populations in the striatum of control monkeys and of parkinsonian monkeys.MethodsUnbiased stereology was used to estimate the volume density of every neuron population in the caudate, putamen and ventral striatum of control monkeys and of monkeys treated with MPTP, which results in striatal dopamine depletion. The various neuron population phenotypes were identified by immunohistochemistry. All analyses were performed within the same subjects using similar processing and analysis parameters, thus allowing for reliable data comparisons.ResultsIn control monkeys, the projection neurons, which express the dopamine‐and‐cAMP‐regulated‐phosphoprotein, 32‐KDa (DARPP‐32), were the most abundant: ~86% of the total neurons counted. The interneurons accounted for the remaining 14%. Among the interneurons, those expressing calretinin were the most abundant (Cr+: ~57%; ~8% of the total striatal neurons counted), followed those expressing Parvalbumin (Pv+: ~18%; 2.6%), dinucleotide phosphate‐diaphorase (NADPH+: ~13%; 1.8%), choline acetyltransferase (ChAT+: ~11%; 1.5%) and tyrosine hydroxylase (TH+: ~0.5%; 0.1%). No significant changes in volume densities occurred in any population following dopamine depletion, except for the TH+ interneurons, which increased in parkinsonian non‐symptomatic monkeys and even more in symptomatic monkeys.ConclusionsThese data are relevant for translational studies targeting specific neuron populations of the striatum. The fact that dopaminergic denervation does not cause neuron loss in any population has potential pathophysiological implications.