bluuebunny/crossref_metadata_2025_split huggingface dataset:
Official Turnover and Corporate ESG Practices: Evidence from China
Authors: yang youde , Xu Guanghua , Li Ruiqian 
Published: October 2022

Abstract
In recent years, environmental, social, governance (ESG) have gradually received widespread attention. However, few studies have focused on the impact of situational factors on corporate ESG practice decisions. Based on this, this paper analyzes a sample of 9428 observations of Chinese A-share listed firms during the period 2009-2019 in an attempt to explore the impact of local officials' turnover on corporate ESG practices, and analyze the boundary effects of this impact at three levels: regional, industry, and corporate. Our results suggest that: (1) Turnover of local officials can lead to changes in economic policies and reallocation of political resources, which can stimulate companies' "risk aversion motive" and "development motive" and thus promote their ESG practices; (2) This effect will be enhanced by the high level of government intervention, the high level of competition in the industry, and the private sector. (3) Further test finds that turnover of local officials can have a significant impact on corporate ESG only when the officials are abnormal turnover and when the regional economic development is good in the current period. This paper enriches research related to decision-making scenarios of corporate ESG practices from a macro-institutional perspective.
The twisting direction of nAChR α7-ivermectin is opposite to that of the activated state
Authors: Yang Yue , Arai Tatsuya , SASAKI DAISUKE , Inagaki Hidetoshi , Ohashi Sumiko , Kuramochi Masahiro , Sekiguchi Hiroshi , Mio Kazuhiro , Kubo Tai , Sasaki Yuji 
Published: October 2022

AbstractThe alpha 7 nicotinic acetylcholine receptor (nAChR α7) is composed of five α7 subunits arranged symmetrically around a central pore. nAChR α7 is localized in the central nervous system and immune cells and could be a target for treating Alzheimer’s disease and schizophrenia. Acetylcholine (ACh) is a ligand that opens the channel, although prolonged application results in a decrease in the response. Ivermectin (IVM) was reported as one of the positive allosteric modulators, since the binding of IVM to the channel enhances ACh-evoked alpha 7 currents. The molecular dynamics of the ligand-bound state of nAChR α7 have not been exhaustively studied. We utilized a diffracted X-ray tracking method to monitor the twisting and tilting motion of nAChR α7 without a ligand, with ACh, with IVM, and with both ACh and IVM (ACh_IVM). The results showed that nAChR α7 twisted counterclockwise with the channel opening in the presence of ACh and clockwise without the channel opening in the presence of IVM. The mechanism of channel opening may be due to the twisting of the five α7 subunits together, where one or more of them are squeezed and move downward or upward.
Source-specific Ecological Risk of Atmospheric PM2.5-Bound Metals and Implications for Air Pollution Control: A Regional Perspective from China
Authors: Lin Weiwei , Zhang Hedi , Lai Yuming , Zhuang Shuling , Wei Qiannan , Fu Shaojie , Mai Dejian , Yuan Luan , Wei Qing , Yue Dingli , Hu Qiansheng 
Published: October 2022

Abstract
Atmospheric PM2.5-bound metals are a globally recognized environmental concern that poses a great threat to regional ecosystem health. Determining their ecological risk and sources is imperative for devising effective control strategies. However, little is known about source apportionment of ecological risk of heavy metals bounded to PM2.5. We aimed to quantify the source-specific ecological risk of PM2.5-bound heavy metals from a regional perspective. From December 2014 through July 2016, 23 types of PM2.5-bound metals were measured at nine cities in the Pearl River Delta (PRD), China, one of the most economically dynamic regions in the world. An integrated approach incorporating a receptor model and an ecological risk assessment method was developed to evaluate the source contribution to ecological risk from PM2.5-bound metals. We quantified the ecological risk of six potentially toxic metals (Cd, Pb, Cu, As, Zn, Cr), their total potential ecological risk index (PERI) in the PRD was 1107.81, almost twice the standard for extremely high ecological risk (600). The high potential ecological risk was mainly due to Cd. Higher ecological risks arose from industrial and vehicle emissions, followed by coal burning, dust emissions and heavy oil burning. This study provides some evidence that atmospheric Cd at levels lower than the World Health Organization standard can still pose serious ecological risk, and highlights the importance of vehicle non-exhaust emissions in ecological risk caused by airborne metals, providing new insight into the control strategy for PM2.5.
Sustained high expression of BTLA on CD4+ T cell contributes to high rate of bacterial infection and mortality in patients with HBV-related acute-on-chronic liver failure via CD4+ T cell exhaustion
Authors: Zhang Jiming , Yu Xueping , Yang Feifei , Sun Jian , Qiu Chao , Zheng Yijuan , Zhao Weidong , Yuan Songhua , Zeng Dawu , Long Jianfei , Zhu Mengqi , Zhang Xueyun , Wu Jingwen , Ma Zhenxuan , Zhu Haoxiang , Su Milong , Xu Jianqing , Li Bin , Mao Richeng , Su Zhi-Jun 
Published: October 2022

Abstract
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by susceptibility to infection and T-cell immune exhaustion. Moreover, expression of the B- and T-lymphocyte attenuator (BTLA), which maintains T-cell immune tolerance, increases in HBV-ACLF patients. However, the mechanisms underlying BTLA expansion in HBV-ACLF patients, and whether BTLA can induce T-cell immune exhaustion and increase the risk of infection remain unclear. Here, we demonstrate that BTLA expression was significantly increased in the T effector memory subtype and all subgroups of circulating and intrahepatic CD4+T cells from patients with HBV-ACLF. The prevalence of BTLA+CD4+T cells was positively correlated with disease severity, prognosis, and infectious complications. BTLA expression was upregulated by the IL-6 and TNF-α signaling pathways, but blocked by their inhibitors. Crosslinking of BTLA phosphorylated the SHP1/2 protein and activated the PI3K-Akt-GSK-3β pathway to inhibit the activation, proliferation, and cytokine production of CD4+T cells while promoting their apoptosis; contrastingly, BTLA knockdown promoted their activation and proliferation. BTLA−/− ACLF mice showed increased secretion of cytokines, CD4+T-cell activation, and reduced mortality and bacterial burden. Together, these data will be helpful for elucidating the pathogenesis of HBV-ACLF and in the identification of new drug targets.
Suicidal Behaviors and Associated Factors among Ethiopian Patients Attending an Emergency Department
Authors: Wordefo Dureti Kassim , Kassim Faiz Mohammed , Birhanu Elizabeth , Mamo Girma 
Published: October 2022

Abstract

Background: Emergency departments (ED) are an important site for screening patients with suicidal behaviors. However, there is insufficient data in low-and middle-income countries regarding the magnitude of suicidal attempts among patients attending EDs. Therefore, the present study aimed to screen suicidal behavior and factors associated with suicide in patients attending an ED of Addis Ababa Burn, Emergency and Trauma Hospital, Ethiopia.Method:A facility-based quantitative cross-sectional study was conducted between April and June 2018. A total of 398 participants were recruited using a consecutive sampling technique. The collected data collected includes structured questionnaires containing sociodemographic determinants, chronic medical illness conditions, substance use characteristics, social support level, common mental disorders screening, suicidal behaviors assessment and suicidal attempts reason and methodResults:The prevalence of suicidal behavior and suicidal attempts were 8 % and 6.3 %, respectively. Suicide was attempted most frequently in the 18-24 age group. There was no overall difference in sex distribution for suicidal attempts. However, there were sex-based differences when the age group was taken into consideration. The commonest underlying reason for the attempt was social reasons (44 %), while the most frequently reported attempt method was hanging (36 %). No single factor was found to be significantly associated with the suicidal attempt.Conclusion:Although suicidal behaviors are more common in patients attending the ED than in the general population, these facts have previously been ignored in patient attending EDs. The present findings support the need for a more detailed assessment of suicidal behaviours in patients attending ED.
Study on the influence of ultrasonic assisted cutting on the surface quality of CFRP
Authors: Wang Xiaobo , Song Chaosheng , Tong Jinglin , Li Lulu , Wu Mingqiang , Zhao Bo 
Published: October 2022

Abstract
In order to study the influence of machining methods and parameters on the surface quality of carbon fiber reinforced composites (CFRP) in the cutting process, the finite element simulation model of ultrasonic assisted cutting CFRP was established, the simulation results show that the damage degree of CFRP in the machining process is reduced by the introduction of longitudinal ultrasonic, the additional torsional ultrasonic vibration of the tool improves the surface quality most significantly, and the damage degree characteristic is significantly affected by the fiber angle (angle between cutting speed direction and fiber direction). To verify the correctness of the simulation model, the ultrasonic assisted torsion and longitudinal cutting tests of CFRP discs were carried out respectively, and compared with the ordinary cutting process, the test result shows that the fiber cutting angle is the main factor affecting the surface roughness of CFRP, the introduction of ultrasonic changes the mechanism of the tool on the workpiece and the mode of fiber fracture, and effectively inhibits the surface damage of CFRP, which is consistent with the simulation model. When the tool is subjected to additional torsional vibration, the surface roughness can be reduced by about 4∼6 µm, the effect of ultrasonic is better in the low-speed area, and the direction of fiber can be weakened by high-speed processing. When the amplitude is in the range of 0∼6 µm, with the increase of amplitude, the advantage of ultrasonic is more obvious, and the directional inhibition of fiber is more obvious.
Contribution to the study of groundwater quality and validation of their vulnerabilities to pollution using GIS. Case of the Plio-Pleistocene aquifer of the Essaouira syncline - Morocco
Authors: OUZERBANE Zakaria , HMAIDI Abdellah EL , ESSAHLAOUI Ali , LOULIDA Soumia , OUALI Anas El , NAJINE Abdessamad 
Published: October 2022

Abstract
In coastal areas, groundwater is the main source of consumption for drinking water, industry and agriculture. The Essaouira syncline is part of the Moroccan Atlantic coast, it is an area which is given a heavy responsibility in the socio-economic development of Morocco. The study area is limited to the north by the Jbeb Hadid, to the south by the Tidzi river, to the east by the reliefs of the South Chiadma, the reliefs of the North Haha and the diapir of the Tidzi, and to the West by the 'Atlantic Ocean. In this article, we have tried to study the quality of groundwater by applying multi-criteria methods and to validate the pollution vulnerability map established by the DRASTIC method. The combination of GIS and multi-criteria analysis confirms the validity of the DRASTIC map with a better correlation between areas with high concentrations of chemical elements in groundwater and areas of very high vulnerability to pollution.
Novel genomic risk loci and improved prediction for treatment-resistant schizophrenia are revealed by leveraging polygenic overlap with body-mass index
Authors: O'Connell Kevin , Koch Elise , Lenk Hasan , Akkouh Ibrahim , Hindley Guy , Jaholkowski Piotr , Smith Robert , Holen Børge , Shadrin Alexey , Frei Oleksandr , Smeland Olav , Steen Nils Eiel , Dale Anders , Molden Espen , Djurovic Srdjan , Andreassen Ole 
Published: October 2022

Abstract
Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were identified. Clozapine is shown to be the superior drug in terms of clinical effect in TRS; at the same time it has a serious side effect profile, including weight gain. Here, we sought to increase power for genetic discovery and improve polygenic prediction of TRS, by leveraging genetic overlap with Body Mass Index (BMI). We analysed GWAS summary statistics for TRS and BMI applying the conditional false discovery rate (cFDR) framework. We observed cross-trait polygenic enrichment for TRS conditioned on associations with BMI. Leveraging this cross-trait enrichment, we identified 2 novel loci for TRS at cFDR < 0.01, suggesting a role of MAP2K1 and ZDBF2. Further, polygenic prediction based on the cFDR analysis explained more variance in TRS when compared to the standard TRS GWAS. These findings highlight putative molecular pathways which may distinguish TRS patients from treatment responsive patients. Moreover, these findings confirm that shared genetic mechanisms influence both TRS and BMI and provide new insights into the biological underpinnings of metabolic dysfunction and antipsychotic treatment.
New composite based on recycled dust wood for fast neutrons and gamma rays shielding
Authors: Elashmawy Mostafa M. , Abdelwahab Nesreen R. , Abdallah Noha 
Published: October 2022

Abstract
Composite with 6 different concentrations of Dust Wood, B2O3, and Styrene-Butadiene Rubber were prepared and tested for fast neutrons and gamma rays shielding using a narrow collimated beam from 241Am-Be and 137Cs sources respectively. Composite of 50% Dust Wood, 25% Styrene-Butadiene Rubber and 25% B2O3 is found to have the highest shielding effectiveness for both neutrons and gamma radiation. Results were then compared with those obtained theoretically for borated polyethylene at the same concentrations of boron. The new composite is found to be about 29% less effective for neutron shielding and about 15% more effective in case of gamma shielding. In a standard case study; door shielding in radiotherapy bunker; a thickness of 4.5 cm of the proposed composite could replace 3.2 cm of borated polyethylene (B = 5% wt). The new composite has two major advantages: first, it recycles Dust Wood as an unwanted waste, which helps protect the environment, and second, it provides a locally produced alternative to pricey BPE at a cost that is between 60% and 70% less than the average price worldwide.
Determination of Orbital Periastron and Apastron Points and Their Time Values on h+ and hX Gravitational Waveforms in Eccentric Binary Systems
Authors: Özçelik Hakan 
Published: October 2022

Abstract
In this study, we analyze the gravitational wave polarization h+ and h× waveforms according to the true and eccentric anomalies for a binary system with eccentricity. For such a binary system, using the h+ and h× waveforms according to the true and eccentric anomalies, we plot graphs according to different values of eccentricity e and show the locations of orbital periastron and apastron points on waveforms. In the next step, taking into account the orbital inclination angle i, argument of periastron ω0 and longitude of the ascending node Ω0, according to any observer, we derive h+ and h× waveforms more comprehensively with respect to the true anomaly of a binary system with eccentricity. As an example, we apply these latter derived expression to PSR B1534+12 and PSR B1913+16 binary pulsar systems. Using current data of these binary pulsar systems and the values of ω0 and Ω0 parameters through literature (and also used arbitrary values for these parameters), we obtain different h+ and h× waveforms. Finally, by using the h+ waveforms generated for these binary pulsar systems, we obtain the times for the periastron and apastron points and the time to arrive from the periastron to the apastron (t1) and the time arrive from the apastron to periastron (t2), and then we conclude the study by discussing these results.
Deformation characteristics, mechanisms, and dominant factors involved in rainfall-hydrodynamic pressure landslides: case study of the Sanmendong landslide in the Three Gorges Reservoir
Authors: Fan Zhihong , Wang Shimei , Wang Li , Guo Fei , Huang Junjie , Li Xiaowei 
Published: October 2022

Abstract
A 16-year surface macroscopic survey and GPS monitoring results from the Sanmendong landslide in the Three Gorges Reservoir Area have demonstrated that the deformation degree of the landslide is distinctly correlated with rainfall and fluctuations in reservoir levels. In this study, the seepage field and stability coefficient of Sanmendong landslide deformation under the conditions of rainfall were estimated, and fluctuations in the reservoir water level and their coupling effects were simulated and calculated, respectively. The simulation results revealed that as the water level rises, the seepage force is directed to the inside of the slope, thus creating conditions that bolster landslide stability. However, when the reservoir water level drops or rainfall occurs, the seepage force is directed to the outside of the slope, thereby hindering landslide stability. GPS monitoring data and the correlation between reservoir water level fluctuations, rainfall, and landslide deformation were further analyzed. The analysis revealed a positive correlation between rainfall and the displacement rate at monitoring point ZG361, with a high grey correlation degree (0.761). However, the correlation between the rate of fluctuating reservoir water levels and the displacement rate at monitoring point ZG361 was insignificant. The stability calculation demonstrated that under normal Three Gorges Reservoir operation, a decrease in water level only decreases the stability coefficient by < 1%, whereas the heavy rainfall process decreases the stability coefficient by > 10%. The above results prove that the rainfall is the primary driver governing Sanmendong landslide deformation.
WITHDRAWN: Investigating the miRNA of the Chinese herb Gecko on the cross-species regulation network of hepatocellular carcinoma
Authors: Li Zhaosheng , Zhao Jing , Tong Dongchang , Yi Chun , Deng Zhe , Huang Zhen , Wuang Yongli , Tian XueFei 
Published: October 2022

Abstract
Gecko is a traditional Chinese herb that has been extensively documented as a treatment for various illnesses, including cancer, for thousands of years in ancient Chinese literature. The development of Chinese medicinal preparations and the role of small molecule active ingredients in Chinese medicine have recently emerged as new research hotspots. However, the potential cross-species regulatory mechanisms of microRNAs (miRNAs) from Gecko components in hepatocellular carcinoma (HCC) are not fully understood. In this study, we isolated and extracted total RNA from Chinese herbal Gecko tablets after powdering and screened the Gecko miRNA expression dataset after high-throughput sequencing to compare with the survival-related differentially expressed miRNA dataset in human HCC to identify new Gecko and HCC survival-related miRNA-mRNA regulatory networks. The miR-100-5p, miR-99a-5p, and miR-101-3p were identified as critical miRNAs for the role of Geckos in human HCC. Stepwise prediction and validation, nine downstream mRNAs (EZH2, KPNA2, LMNB1, LRRC1, MRGBP, SMARCD1, STMN1, SUB1, and UBE2A) were found to be determined as key miRNAs interacting with essential genes that interact with each other. A miRNA-mRNA regulatory network consisting of these key genes was constructed, and GO, KEGG enrichment analysis indicated that these key mRNAs might be associated with the suppression and progression of hepatocellular carcinoma. Importantly, immune infiltration analysis showed that the miRNA network was significantly associated with the infiltration abundance of multiple immune cells. These findings suggest that Gecko miRNAs may inhibit HCC progression and treat HCC by targeting critical miRNA-mRNA networks for cross-species regulation. It also provides a reference for future research and new drug development.
Prevalence of Food Insecurity and Associated Factors Among Households in Waliso Town, Oromia, Ethiopia
Authors: Tulem Tariku Gurara , Ayana Mulatu 
Published: October 2022

Abstract

Background: -Food insecurity is one of the underlying causes of malnutrition. And it`s a condition where people don`t have access to adequate amounts of safe and nutritious food and don`t consume the food that they have to grow normally and conduct an active and healthy life. Recently, urban food insecurity is a top agenda in Ethiopia, as households prone to food insecurity are rising because of various factors. However most of studies conducted on household food insecurity in Ethiopia before were in rural. hence we have aimed to assess the prevalence of food insecurity and associated factors among households in Waliso town, Oromia, EthiopiaMethods:Community-based cross-sectional study design was used from 17/12/2021 to 16/01/2022 among randomly selected 397 households in Waliso town. Data collection was done using a structured questionnaire and data were entered using Epi Info 7 and exported to SPSS version 20 software for analysis. To identify factors associated with household food insecurity, multivariable binary logistic regression analyses were done. An adjusted odds ratio along with a 95% confidence interval were estimated to measure the strength of the association. In this study, the level of statistical significance was declared at p<0.05.Results:The prevalence of household food insecurity was 63.4% 95% CI (58.6%, 68.2%). Factors associated with household food insecurity were family sizes 4-5[(AOR=2.26, 95% CI:- (1.13, 4.53)] and family sizes 6+[(AOR=4.12, 95% CI:-(1.62, 10.52)], having dependents 1-2 [(AOR= 3.95, 95% CI:-(1.78, 8.8)], >3 dependents [(AOR=5.59, 95% CI:-(2.01, 15.54)], Household head employment status; unemployed [(AOR=4.23, 95%CI:-(1.47, 12.2)], self-employed [(AOR=2.6, 95% CI:- (1.09, 6.18)], wage laborer[(AOR=7.95, 95% CI:- (2.68, 23.56)], Households live in Kebele house[(AOR=3.39. 95% CI:- (1.63, 7.08)], live in a private rental house[(AOR=3.69 95% CI:-(1.87,7.27)], Wealth index (poor) [(AOR=3.0, 95% CI:- (1.42, 5.89)].Conclusion:Majority of households were food insecure in Waliso town. Households had large family sizes, multiple dependents, Employment in Informal sectors, low wealth Index (poor), and not owning a house were significantly associated with household food insecurity. Hence, the Woliso town Administration should alleviate factors associated with household food insecurity by employing multi-sectorial collaboration.