bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on multi-person collaborative design of BIM drawing based on blockchain
Authors: Wang Jinlong , Shen Yumin , Xiong Xiaoyun , Wang Xu , Fang Xiaoxue 
Published: September 2022

AbstractThe existing multi-person collaborative design scheme of Building Information Modeling (BIM) integrated with blockchain faces problems such as poor reliability of BIM drawing, inconsistent drawing information, redundant information, and inaccurate protection of copyright interests. This paper proposes a multi-person collaborative design model for BIM drawing that combines blockchain and InterPlanetary File System (IPFS). This model uses blockchain to store drawing design information to protect the copyright interests of designers and combines IPFS to ensure the reliability of drawing. A cycle division mechanism is designed to solve the problem of drawing information synchronization when multiple people collaborate in design. The Semantic Differential Transaction (SDT) method is used to achieve incremental update of drawing and reduce the information redundancy of the blockchain. Finally, a comparative analysis and validation evaluation of the scheme is carried out, and the usability of the scheme is illustrated with an illustrative example. The results show that: (1) proposed scheme is feasible for multi-person collaborative design; (2) proposed scheme can effectively ensure the reliability of drawing and reduce the redundancy of blockchain information, so as to achieve copyright protection for designers.
Technological and functional analysis of 80–60 ka bone wedges from Sibudu (KwaZulu-Natal, South Africa)
Authors: d’Errico Francesco , Backwell Lucinda R. , Wadley Lyn , Geis Lila , Queffelec Alain , Banks William E. , Doyon Luc 
Published: September 2022

AbstractFully shaped, morphologically standardized bone tools are generally considered reliable indicators of the emergence of modern behavior. We report the discovery of 23 double-beveled bone tools from ~ 80,000–60,000-year-old archaeological layers at Sibudu Cave in KwaZulu-Natal, South Africa. We analyzed the texture of use-wear on the archaeological bone tools, and on bone tool replicas experimentally used in debarking trees, processing rabbit pelts with and without an ochre compound, digging in sediment in and outside a cave, and on ethnographic artefacts. Debarking trees and digging in humus-rich soil produce use-wear patterns closely matching those observed on most Sibudu tools. This tool type is associated with three different Middle Stone Age cultural traditions at Sibudu that span 20,000 years, yet they are absent at contemporaneous sites. Our results support a scenario in which some southern African early modern human groups developed and locally maintained specific, highly standardized cultural traits while sharing others at a sub-continental scale. We demonstrate that technological and texture analyses are effective means by which to infer past behaviors and assess the significance of prehistoric cultural innovations.
Development of individual identification method using thoracic vertebral features as biometric fingerprints
Authors: Sato Mitsuru , Kondo Yohan , Okamoto Masashi , Takahashi Naoya 
Published: September 2022

AbstractIdentification of individuals is performed when a corpse is found after a natural disaster, incident, or accident. DNA and dental records are frequently used as biometric fingerprints; however, identification may be difficult in some cases due to decomposition or damage to the corpse. The present study aimed to develop an individual identification method using thoracic vertebral features as a biological fingerprint. In this method, the shortest diameter in height, width, and depth of the thoracic vertebrae in the postmortem image and a control antemortem were recorded and a database was compiled using this information. The Euclidean distance or the modified Hausdorff distance was calculated as the distance between two points on the three-dimensional feature space of these measurement data. The thoracic vertebrae T1-12 were measured and the pair with the smallest distance was considered to be from the same person. The accuracy of this method for identifying individuals was evaluated by matching images of 82 cases from a total of 702 antemortem images and showed a hit ratio of 100%. Therefore, this method may be used to identify individuals with high accuracy.
Differentiating a pachychoroid and healthy choroid using an unsupervised machine learning approach
Authors: Mirshahi Reza , Naseripour Masood , Shojaei Ahmad , Heirani Mohsen , Alemzadeh Sayyed Amirpooya , Moodi Farzan , Anvari Pasha , Falavarjani Khalil Ghasemi 
Published: September 2022

AbstractThe purpose of this study was to introduce a new machine learning approach for differentiation of a pachychoroid from a healthy choroid based on enhanced depth-optical coherence tomography (EDI-OCT) imaging. This study included EDI-OCT images of 103 eyes from 82 patients with central serous chorioretinopathy or pachychoroid pigment epitheliopathy, and 103 eyes from 103 age- and sex-matched healthy subjects. Choroidal features including choroidal thickness (CT), choroidal area (CA), Haller layer thickness (HT), Sattler-choriocapillaris thickness (SCT), and the choroidal vascular index (CVI) were extracted. The Haller ratio (HR) was obtained by dividing HT by CT. Multivariate TwoStep cluster analysis was performed with a preset number of two clusters based on a combination of different choroidal features. Clinical criteria were developed based on the results of the cluster analysis, and two independent skilled retina specialists graded a separate testing dataset based on the new clinical criteria. TwoStep cluster analysis achieved a sensitivity of 1.000 (95-CI: 0.938–1.000) and a specificity of 0.986 (95-CI: 0.919–1.000) in the differentiation of pachy- and healthy choroid. The best result for identification of pachychoroid was obtained for a combination of CT, HR, and CVI, with a correct classification rate of 0.993 (95-CI: 0.980–1.000). Based on the relative variable importance (RVI), the cluster analysis prioritized the choroidal features as follows: HR (RVI: 1.0), CVI (RVI: 0.87), CT (RVI: 0.70), CA (RVI: 0.59), and SCT (RVI: 0.27). After performing a receiver operating characteristic curve analysis on the cluster membership variable, a cutoff point of 389 µm and 0.79 was determined for CT and HR, respectively. Based on these clinical criteria, a sensitivity of 0.793 (95-CI: 0.611–0.904) and a specificity of 0.786 (95-CI: 0.600–0.900) and 0.821 (95-CI: 0.638–0.924) were achieved for each grader. Cohen's kappa of inter-rater reliability was 0.895. Based on an unsupervised machine learning approach, a combination of the Haller ratio and choroidal thickness is the most valuable factor in the differentiation of pachy- and healthy choroids in a clinical setting.
Development of a new scoring method in the neurofunctional assessment of preterm infants
Authors: Picciolini Odoardo , Giannì Maria Lorella , Messina Laura , Pesenti Nicola , Fumagalli Monica , Gardon Laura , Squarza Chiara , Mosca Fabio , Fontana Camilla , Porro Matteo 
Published: September 2022

AbstractInfants born preterm are at high risk of presenting neurodevelopmental delay. The Neurofunctional Assessment (NFA) describes infants’ neurodevelopment through the evaluation of six different domains. This study aimed to evaluate how, in a cohort of preterm infants, each NFA domain assessed at 3 months of corrected age (CA) was associated with neurodevelopment at 2 years of CA using the Griffiths Mental Developmental Scales Extended Revised (GMDS-ER). In addition, by introducing the NFA complexity score (CS), the study aimed to define a threshold that can help clinicians discriminate infants at higher risk of later neurodevelopmental delay. We conducted an observational, longitudinal study including 211 preterm infants. At 3 months of CA, infants who had normal scores in each domain showed a significantly higher GMDS-ER global quotient (GQ) at 2 years of CA. In addition, linear model results showed a significant negative relationship between the NFA CS and 2-year GMDS-ER GQ (estimate: − 0.27; 95% CI − 0.35, − 0.20; p value < 0.001). Each 10-point increase in the NFA CS was associated with an average 2.7-point decrease in the GMDS GQ. These results highlight how the NFA domains and NFA CS are compelling instruments for the early identification of children at risk for long-term adverse outcomes.
Elevated G-CSF, IL8, and HGF in patients with definite Meniere’s disease may indicate the role of NET formation in triggering autoimmunity and autoinflammation
Authors: Zou Jing , Zhao Zikai , Song Xianmin , Zhang Guoping , Li Hongbin , Zhang Qing , Pyykkö Ilmari 
Published: September 2022

AbstractThe etiology and mechanism causing Meniere’s disease (MD) are not understood. The present study investigated the possible molecular mechanism of autoimmunity and autoinflammation associated with MD. Thirty-eight patients with definite MD and 39 normal volunteers were recruited, and 48 human cytokines/chemokines were quantified. In patients with MD pure tone audiograms, tympanograms and standard blood tests were performed. The mean hearing loss in the worse ear was 44.1 dB nHL. Compared to the referents, the concentrations of TNFα, IL1α, IL8, CTACK, MIP1α, MIP1β, G-CSF, and HGF in the sera of patients with MD were significantly elevated, while those of TRAIL and PDGFBB were significantly decreased. The area under the receiver operating characteristic curve (AUC) showed that G-CSF, MIP1α, and IL8 were above 0.8 and could be used to diagnose MD (p < 0.01), and the AUCs of CTACK and HGF were above 0.7 and acceptable to discriminate the MD group from the control group (p < 0.01). The revised AUCs (1 − AUC) of TRAIL and PDGFBB were above 0.7 and could also be used in the diagnosis of MD (p < 0.01). The linear regression showed significant correlations between MIP1α and GCSF, between IL2Rα and GCSF, between IL8 and HGF, between MIP1α and IL8, and between SCF and CTACK; there was a marginal linear association between IP10 and MIP1α. Linear regression also showed that there were significant age-related correlations of CTACK and MIG expression in the MD group (p < 0.01, ANOVA) but not in the control group. We hypothesize that G-CSF, IL8, and HGF, which are involved in the development of neutrophil extracellular traps (NETs) and through various mechanisms influence the functions of macrophages, lymphocytes, and dendritic cells, among others, are key players in the development of EH and MD and could be useful in elucidating the pathophysiological mechanisms leading to MD. Biomarkers identified in the present study may suggest that both autoimmune and autoinflammatory mechanisms are involved in MD. In the future, it will be valuable to develop a cost-effective method to detect G-CSF, IL8, HGF, CTACK, MIP1α, TRAIL, and PDGFBB in the serum of patient that have diagnostic relevance.
A tuff interlayer in deep potash-bearing salt rocks and its implication for potash mineralization in the Simao Basin, southwestern China
Authors: Miao Zhong-Ying , Zheng Mian-Ping , Lou Peng-Cheng , Wang Dong , Xu Qi-Hui , Xu Jian-Ming 
Published: September 2022

AbstractThe lithology and genesis of a dark grey clastic interlayer first encountered within the deepest potassium-rich salt body in the Simao Basin, southwestern China, were analysed. Analyses of the petrography, mineralogy, and element geochemistry of the layer revealed that (1) the layer contains quartz crystals with gulf corrosion edges and explosion cracks and angular volcanic ash-sized glasses; (2) the main mineral components of the crystal fragments are chlorite, illite, biotite, quartz, anhydrite, gypsum, magnesite, pyrite, molybdenite, clinopyroxene, and zircon; (3) the rare earth element patterns, Zr/TiO2 and Nb/Y diagrams as well as boron content all indicate a volcanic origin for the layer. Based on these observations, the layer is suggested to be an altered tuff associated with various volcanic fragments dominated by chlorite and formed after alteration of a parent tuff in an alkaline, salty, and low-temperature water body. Discovery of the layer indicates that the potash-bearing salt rocks could have taken in volcanic materials during these volcanic activities and provides the possibility of reliable zircon U‒Pb dating to determine the absolute age of the host rock, which is fundamental in studying the genetic mechanism of this deeply buried salt body.
Silicon as a potential limiting factor for phosphorus availability in paddy soils
Authors: Schaller Jörg , Wu Bei , Amelung Wulf , Hu Zhengyi , Stein Mathias , Lehndorff Eva , Obst Martin 
Published: September 2022

AbstractRice cultivation requires high amounts of phosphorus (P). However, significant amounts of P fertilizer additions may be retained by iron (Fe) oxides and are thus unavailable for plants. At the same time, rice cultivation has a high demand for silicic acid (Si), reducing Si availability after short duration of rice cultivation. By studying a paddy chronosequence with rice cultivation up to 2000 years, we show that Si limitation, observed as early as a few decades of rice cultivation, is limiting P availability along the paddy soils chronosequence. Using near edge X-ray absorption fine structure spectroscopy (NEXAFS) in a scanning transmission (soft) X-ray microscope (STXM) we show release of available P was linked to a Si-induced change in speciation of Fe-phases in soil particles and competition of Si with P for binding sites. Hence, low Si availability is limiting P availability in paddy soils. We propose that proper management of Si availability is a promising tool to improve the P supply of paddy plants.
Domain-specific hearing-in-noise performance is associated with absolute pitch proficiency
Authors: Hsieh I-Hui , Tseng Hung-Chen , Liu Jia-Wei 
Published: September 2022

AbstractRecent evidence suggests that musicians may have an advantage over non-musicians in perceiving speech against noisy backgrounds. Previously, musicians have been compared as a homogenous group, despite demonstrated heterogeneity, which may contribute to discrepancies between studies. Here, we investigated whether “quasi”-absolute pitch (AP) proficiency, viewed as a general trait that varies across a spectrum, accounts for the musician advantage in hearing-in-noise (HIN) performance, irrespective of whether the streams are speech or musical sounds. A cohort of 12 non-musicians and 42 trained musicians stratified into high, medium, or low AP proficiency identified speech or melody targets masked in noise (speech-shaped, multi-talker, and multi-music) under four signal-to-noise ratios (0, − 3, − 6, and − 9 dB). Cognitive abilities associated with HIN benefits, including auditory working memory and use of visuo-spatial cues, were assessed. AP proficiency was verified against pitch adjustment and relative pitch tasks. We found a domain-specific effect on HIN perception: quasi-AP abilities were related to improved perception of melody but not speech targets in noise. The quasi-AP advantage extended to tonal working memory and the use of spatial cues, but only during melodic stream segregation. Overall, the results do not support the putative musician advantage in speech-in-noise perception, but suggest a quasi-AP advantage in perceiving music under noisy environments.
Optical coherence tomography findings after surgery for sub-inner limiting membrane hemorrhage due to ruptured retinal arterial macroaneurysm
Authors: Hayamizu Ryosuke , Totsuka Kiyohito , Azuma Kunihiro , Sugimoto Koichiro , Toyama Taku , Araki Fumiyuki , Shiraya Tomoyasu , Ueta Takashi 
Published: September 2022

AbstractRuptured retinal arterial macroaneurysm (RAM) can cause sub-inner limiting membrane (ILM) hemorrhage, leading to acute vision loss in the elderly. Vitrectomy has been established as an effective treatment to remove hemorrhage and facilitate visual recovery. Although optical coherence tomography (OCT) is useful for the diagnosis of sub-ILM hemorrhage before surgery, little is known about the postoperative OCT findings. Here, we retrospectively investigated the records of nine eyes of nine patients who underwent surgery for sub-ILM hemorrhage due to RAM rupture. On postoperative OCT, hyperreflectivity throughout the full thickness of the central fovea was observed in eight eyes (88.9%), and disruption of the ellipsoid/interdigitation zone (EZ/IZ) was observed in seven out of eight eyes (87.5%). The widths of the hyperreflectivity and EZ disruption gradually decreased. Visual recovery was least favorable in two eyes, in which the EZ line continuation did not recover until the final follow-up. The OCT findings corresponded to the hemorrhagic staining identified on fundus photographs in at least four eyes; as per the fundus photographs the findings persisted even after the hemorrhage was absorbed. In contrast, the OCT findings resembled the appearance before the development of a full-thickness macular hole, suggesting fragility caused by the RAM rupture.
Ethics, law, and politics in palaeontological research: The case of Myanmar amber
Authors: Dunne Emma M. , Raja Nussaïbah B. , Stewens Paul P. , Zin-Maung-Maung-Thein  , Zaw Khin 
Published: September 2022

AbstractFossil material in amber from Myanmar can provide important insights into mid-Cretaceous forest ecosystems. However, Myanmar amber has been receiving increased international attention due to reported links between amber mining and the ongoing humanitarian crisis in northern Myanmar, as well as the legal issues associated with its exportation. Here, we conduct a bibliometric analysis of Myanmar amber publications (1990–2021) and demonstrate how research interest in Myanmar amber is explicitly linked to major political, legal, and economic changes. An analysis of the authorship networks for publications on amber inclusions reveals how current research practices have excluded Myanmar researchers from the field. In addition, the international trade of Myanmar amber with fossil inclusions falls into a legal ‘grey-zone’ which continues to be exploited. This case study vividly demonstrates that systemic changes, alongside an increased awareness of inequitable research practices amongst the broader scientific and allied communities, are urgently needed to curb illegal practices in palaeontology.
The VersaLive platform enables microfluidic mammalian cell culture for versatile applications
Authors: Nocera Giovanni Marco , Viscido Gaetano , Criscuolo Stefania , Brillante Simona , Carbone Fabrizia , Staiano Leopoldo , Carrella Sabrina , di Bernardo Diego 
Published: September 2022

AbstractMicrofluidic-based cell culture allows for precise spatio-temporal regulation of microenvironment, live cell imaging and better recapitulation of physiological conditions, while minimizing reagents’ consumption. Despite their usefulness, most microfluidic systems are designed with one specific application in mind and usually require specialized equipment and expertise for their operation. All these requirements prevent microfluidic-based cell culture to be widely adopted. Here, we designed and implemented a versatile and easy-to-use perfusion cell culture microfluidic platform for multiple applications (VersaLive) requiring only standard pipettes. Here, we showcase the multiple uses of VersaLive (e.g., time-lapse live cell imaging, immunostaining, cell recovery, cell lysis, plasmid transfection) in mammalian cell lines and primary cells. VersaLive could replace standard cell culture formats in several applications, thus decreasing costs and increasing reproducibility across laboratories. The layout, documentation and protocols are open-source and available online at https://versalive.tigem.it/.
Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development
Authors: Zhao Xiaotian , Liang Wenjia , Wang Wenjun , Liu Hailan , Zhang Xiaolei , Liu Chengxin , Zhu Caiting , Cui Baoxia , Tang Yuchun , Liu Shuwei 
Published: September 2022

AbstractInherent hemispheric asymmetry is important for cognition, language and other functions. Describing normal brain and asymmetry development during early development will improve our understanding of how different hemispheres prioritize specific functions, which is currently unknown. Here, we analysed developmental changes in and asymmetry of the proteome in the bilateral frontal lobes of three foetal specimens in the late first trimester of pregnancy. We found that during this period, the difference in expression between gestational weeks (GWs) increased, and the difference in asymmetric expression decreased. Changes in the patterns of protein expression differed in the bilateral frontal lobes. Our results show that brain asymmetry can be observed in early development. These findings can guide researchers in further investigations of the mechanisms of brain asymmetry. We propose that both sides of the brain should be analysed separately in future multiomics and human brain mapping studies.
H‐polarized plane wave diffraction by a slotted cylinder with different surface impedances: Solution by the analytical—Numerical approach
Authors: Tabatadze Vasil , Karaçuha Kamil , Alperen Ömer Faruk , Veliev Eldar 
Published: September 2022

AbstractThe study investigates the H‐polarized plane wave diffraction by a slotted cylinder with different surface impedances employing an analytical‐numerical approach. The solution is obtained by expressing the current distribution on the obstacle with Gegenbauer polynomials considering the edge conditions. To obtain the field and current distribution on the surface, the Leontovich boundary condition on each side of the slotted cylinder is employed. The results are compared with Dirichlet and Neumann boundary condition cases obtained previously. It is observed that the resonant field amplitudes and the location at the resonances strongly depend on the impedance values.
Unabhängige Beschwerdestellen für die Psychiatrie in
Deutschland
Authors: Janse Jozina , Kulke Dieter 
Published: September 2022

Zusammenfassung
Ziel der Studie Erfassung der Bedeutung und Arbeitsweise von
unabhängigen Beschwerdestellen für die Psychiatrie.
Methodik Digitale und postalische Befragung.
Ergebnisse Die häufigsten Anlässe für Beschwerden
sind Unzufriedenheit mit der stationären Behandlung, der gesetzlichen
Betreuung und der Kommunikation mit den Patienten. Netzwerkarbeit gewinnt an
Bedeutung. Beschwerdeführende werden öfters weitervermittelt.
Vermehrte Anfragen von Männern und Suchtpatienten.
Schlussfolgerung Verbesserungsmöglichkeiten liegen in einer
verstärkten Gesetzesverankerung, der Förderung einer
trialogischen Besetzung und der Aufklärung durch Fachpersonal.
Pantoprazole Induced Acute Interstitial Nephritis in a Patient with
Diabetic Ketoacidosis
Authors: Tas Nesrin , Mengen Eda , Goncu Sultan , Tasar Sercin , Kiremitci Saba , Ucakturk Ahmet 
Published: September 2022

IntroductionChildhood-onset type 1 diabetes mellitus (DM) is a common chronic metabolic disease
associated with life-threatening complications. Diabetic ketoacidosis (DKA) is an
acute complication of type 1 DM that has significant mortality mostly due to
cerebral edema. Other putative complications of DKA include hypokalemia,
hypophosphatemia, hypoglycemia, intracerebral and peripheral venous thrombosis,
rhabdomyolysis, acute pancreatitis, and acute kidney injury (AKI) (Murdoch IA et
al., Acta Paediatr 1993; 82:498–500).