bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies
Authors: Rostamian Somayeh , le. Cessie Saskia , Marijt Koen A. , Jukema J. Wouter , Mooijaart Simon P. , van Buchem Mark A. , van Hall Thorbald , Gussekloo Jacobijn , Trompet Stella 
Published: January 2022

Background
Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies were conducted to evaluate the association of cognitive function and risk of cancer death.

Methods
Risk of cancer death and all-cause mortality were reported using hazard ratios (HRs) with 95% confidence interval (CI) in tertiles of cognitive function of PROSPER and Leiden85-Plus Study. Additionally, PubMed, Embase, Web of Science, Cochrane, PsycINFO, Academic Search Premier, CINHAL, and Emcare were searched up to November 1st, 2020 to perform a systematic review and meta-analysis. The relative risks (RRs) with 95%CI of cancer death per each standard deviation lower performance in cognitive measurements were calculated.

Results
Participants of PROSPER had 1.65-fold (95%CI 1.11–2.47) greater risk of cancer death (P for trend = 0.016) and 1.85-fold (95%CI 1.46–2.34) higher risk of all-cause mortality (P for trend<0.001), in multivariable models. Results of the Leiden-85 Plus Study showed that subjects with MMSE score below 24 had a lower chance of cancer death (HR 0.79, 95%CI 0.36–1.70, P for trend = 0.820) but had 2.18-fold (95%CI 1.57–3.02) higher risk of all-cause mortality compared to the reference group (P for trend<0.001). Besides, the results of systematic review and meta-analysis showed that per each standard deviation lower performance in cognitive function, individuals were at a 10% higher chance of cancer death (RR 1.10, 95%CI 1.00–1.20, P-value = 0.044).

Conclusions
Lower cognitive function performance is associated with a marginally increased risk of cancer death, in line with a significantly greater risk of all-cause mortality.
The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease
Authors: Knudsen Kristel S. , Lehmann Sverre , Nielsen Rune , Tangedal Solveig , Haaland Ingvild , Hiemstra Pieter S. , Eagan Tomas M. 
Published: January 2022

Background
The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and proteins in idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

Methods
12 IPF patients, 12 COPD patients and 12 healthy controls were sampled with oral wash (OW), protected bronchoalveolar lavage (PBAL) and right lung protected sterile brushings (rPSB). The antimicrobial peptides and proteins (AMPs), secretory leucocyte protease inhibitor (SLPI) and human beta defensins 1 and 2 (hBD-1 & hBD-2), were measured in PBAL by enzyme linked immunosorbent assay (ELISA).
The V3V4 region of the bacterial 16S rDNA gene was sequenced. Bioinformatic analyses were performed with QIIME 2.

Results
hBD-1 levels in PBAL for IPF were lower compared with COPD. The predominant phyla in IPF were Firmicutes, Bacteroides and Actinobacteria; Proteobacteria were among top three in COPD. Differential abundance analysis at genus level showed significant differences between study groups for less abundant, mostly oropharyngeal, microbes. Alpha diversity was lower in IPF in PBAL compared to COPD (p = 0.03) and controls (p = 0.01), as well as in rPSB compared to COPD (p = 0.02) and controls (p = 0.04). Phylogenetic beta diversity showed significantly more similarity for IPF compared with COPD and controls. There were no significant correlations between alpha diversity and AMPs.

Conclusions
IPF differed in microbial diversity from COPD and controls, accompanied by differences in antimicrobial peptides. Beta diversity similarity between OW and PBAL in IPF may indicate that microaspiration contributes to changes in its microbiome.
Association between being metabolically healthy/unhealthy and metabolic syndrome in Iranian adults
Authors: Tabatabaei-Malazy Ozra , Saeedi Moghaddam Sahar , Masinaei Masoud , Rezaei Nazila , Mohammadi Fateh Sahar , Dilmaghani-Marand Arezou , Abdolhamidi Elham , Razi Farideh , Khashayar Patricia , Mahdavihezaveh Alireza , Mirab Samiee Siamak , Larijani Bagher , Farzadfar Farshad 
Published: January 2022

Introduction
The prevalence of metabolically healthy obesity (MHO) varies based on different criteria. We assessed the prevalence of MHO and metabolic unhealthiness based on body mass index (BMI) and their association with metabolic syndrome (MetS) in a nation-wide study.

Methods
Data were taken from the STEPs 2016 study, from 18,459 Iranians aged ≥25 years. Demographic, metabolic, and anthropometric data were collected. Subjects were stratified by BMI, metabolic unhealthiness, and having MetS. The latter was defined based on National Cholesterol Education Program Adult Treatment Panel III 2004 (NCEP ATP III), was then assessed.

Results
The prevalence of MHO and metabolic unhealthiness in obese subjects was 7.5% (about 3.6 million) and 18.3% (about 8.9 million), respectively. Most of the metabolic unhealthy individuals were female (53.5%) or urban residents (72.9%). Low physical activity was significantly and positively associated (Odds Ratio: 1.18, 95% CI: 1.04–1.35) with metabolic unhealthiness, while being a rural residence (0.83, 0.74–0.93), and having higher education (0.47, 0.39–0.58) significantly but negatively affected it. Dyslipidemia was the most frequent MetS component with a prevalence rate of 46.6% (42.1–51.1), 62.2% (60.8–63.6), 76.3% (75.1–77.5), and 83.4% (82.1–84.6) among underweight, normal weight, overweight and obese phenotypes, respectively.

Conclusion
BMI aside, an additional set of criteria such as metabolic markers should be taken into account to identify normal weight but metabolically unhealthy individuals. Given the highest prevalence of dyslipidemia among obese subjects, further interventions are required to raise public awareness, promote healthy lifestyles and establish lipid clinics.
Self-similar solutions to fully nonlinear curvature flows by high powers of curvature
Authors: Gao Shanze , Li Haizhong , Wang Xianfeng 
Published: January 2022

Abstract
In this paper, we investigate closed strictly convex hypersurfaces in

ℝ

n
+
1

{\mathbb{R}^{n+1}}

which shrink self-similarly under a large family of fully nonlinear curvature flows by high powers of curvature. When the speed function is given by powers of a homogeneous of degree 1 and inverse concave function of the principal curvatures with power greater than 1, we prove that the only such hypersurfaces are round spheres. We also prove that slices are the only closed strictly convex self-similar solutions to such curvature flows in the hemisphere

𝕊
+

n
+
1

{\mathbb{S}^{n+1}_{+}}

with power greater than or equal to 1.
Geometric nilpotent Lie algebras and zero-dimensional simple complete intersection singularities
Authors: Hussain Naveed , Yau Stephen S.-T. , Zuo Huaiqing 
Published: January 2022

Abstract
The Levi theorem tells us that every finite-dimensional Lie algebra is the semi-direct product of a semi-simple Lie algebra and a solvable Lie algebra. Brieskorn gave the connection between simple Lie algebras and simple singularities. Simple Lie algebras have been well understood, but not the solvable (nilpotent) Lie algebras. Therefore, it is important to establish connections between singularities and solvable (nilpotent) Lie algebras. In this paper, we give a new connection between nilpotent Lie algebras and nilradicals of derivation Lie algebras of isolated complete intersection singularities. As an application, we obtain the correspondence between the nilpotent Lie algebras of dimension less than or equal to 7 and the nilradicals of derivation Lie algebras of isolated complete intersection singularities with modality less than or equal to 1. Moreover, we give a new characterization theorem for zero-dimensional simple complete intersection singularities.
Solving nonlinear boundary value problems by a boundary shape function method and a splitting and linearizing method
Authors: Liu Chein-Shan , El-Zahar Essam R. , Chang Chih-Wen 
Published: January 2022

Abstract
In the paper, we develop two novel iterative methods to determine the solution of a second-order nonlinear boundary value problem (BVP), which precisely satisfies the specified non-separable boundary conditions by taking advantage of the property of the corresponding boundary shape function (BSF). The first method based on the BSF can exactly transform the BVP to an initial value problem for the new variable with two given initial values, while two unknown terminal values are determined iteratively. By using the BSF in the second method, we derive the fractional powers exponential functions as the bases, which automatically satisfy the boundary conditions. A new splitting and linearizing technique is used to transform the nonlinear BVP into linear equations at each iteration step, which are solved to determine the expansion coefficients and then the solution is available. Upon adopting those two novel methods very accurate solution for the nonlinear BVP with non-separable boundary conditions can be found quickly. Several numerical examples are solved to assess the efficiency and accuracy of the proposed iterative algorithms, which are compared to the shooting method.
An improved proximal method with quasi-distance for nonconvex multiobjective optimization problem
Authors: Amir Fouzia , Farajzadeh Ali , Alzabut Jehad 
Published: January 2022

Abstract
Multiobjective optimization is the optimization with several conflicting objective functions. However, it is generally tough to find an optimal solution that satisfies all
objectives from a mathematical frame of reference. The main objective of this article is to present an improved proximal method involving quasi-distance for constrained multiobjective optimization problems under the locally Lipschitz condition of the cost function. An instigation to study the proximal method with quasi distances is due to its widespread applications of the quasi distances in computer theory. To study the convergence result, Fritz John’s necessary optimality condition for weak Pareto solution is used. The suitable conditions to guarantee that the cluster points of the generated sequences are Pareto–Clarke critical points are provided.
Clinical, pathological and molecular spectrum of patients with glycogen storage diseases in Pakistan
Authors: Ahmed Sibtain , Akbar Fizza , Ali Amyna Jaffar , Afroze Bushra 
Published: January 2022

Abstract

Objectives
Evaluation of clinical, biochemical and molecular analysis of Pakistani patients with hepatic GSDs.

Methods
Medical charts, biochemical, histopathological and molecular results of patients with hepatic GSD were reviewed.

Results
Out of 55 GSD patients, 41 (74.5%) were males and 14 (25.5%) were females with consanguinity in 50 (91%) patients. The median age of initial symptoms, clinic diagnosis and molecular diagnosis were 450 (IQR: 270–960), 1,095 (IQR: 510–1,825) and 1717 (IQR: 796–3,011) days, respectively. Molecular analysis and enzyme activity was available for 33 (60%) and two patients, respectively. GSD III (n=9) was most prevalent followed by GSD Ib (n=7), GSD IXc (n=6), GSD VI (n=4), GSD Ia (n=3), GSD XI (n=3), GSD IXb (n=2) and GSD IXa (n=1). In patients (n=33) who underwent molecular analysis; 19 different variants in eight genes associated with GSD were identified. We also report five novel variants, two in SLC37A4, one in AGL and two in PYGL contributing to the diagnosis of GSD Ib, GSD III and GSD VI, respectively.

Conclusions
Fifty-five patients of GSDs in 26 families from a single care provider indicate a relatively high frequency of GSD in Pakistan, with multiple unrelated families harboring identical disease-causing variants, on molecular analysis, including two known pathogenic variants in SLC37A4 and PHKG2, and a novel variant in AGL.
Some new results on the weaving of K-g-frames in Hilbert spaces
Authors: Xiang Zhong-Qi 
Published: January 2022

Abstract
In this paper, we provide some conditions for a K-woven pair of K-g-frames to be preserved under an operator and particularly, we report that applying two different operators to a K-woven pair of K-g-frames can leave them K-woven. Several new methods on the construction of K-woven pair of K-g-frames are also given. We end the paper with a new perturbation result on the weaving of K-g-frames, which shows that, under the perturbation condition involved in one known result on this topic, two K-g-frames can be K-woven in the whole space, not merely in the subspace Range(K).
Pharmaceutical interest of in-silico approaches
Authors: Kumar Dinesh , Sharma Pooja , Mahajan Ayush , Dhawan Ravi , Dua Kamal 
Published: January 2022

Abstract
The virtual environment within the computer using software performed on the computer is known as in-silico studies. These drugs designing software play a vital task in discovering new drugs in the field of pharmaceuticals. These designing programs and software are employed in gene sequencing, molecular modeling, and in assessing the three-dimensional structure of the molecule, which can further be used in drug designing and development. Drug development and discovery is not only a powerful, extensive, and an interdisciplinary system but also a very complex and time-consuming method. This book chapter mainly focused on different types of in-silico approaches along with their pharmaceutical applications in numerous diseases.
Membrane techniques in the production of beverages
Authors: Staszak Katarzyna , Wieszczycka Karolina 
Published: January 2022

Abstract
The most important developments in membrane techniques used in the beverage industry are discussed. Particular emphasis is placed on the production of fruit and vegetable juices and nonalcoholic drinks, including beer and wine. This choice was dictated by the observed consumer trends, who increasingly appreciate healthy food and its taste qualities.
Impaired Stretch-Shortening Cycle Function Persists Despite Improvements in Reactive Strength After Anterior Cruciate Ligament Reconstruction
Authors: Read Paul J. , Pedley Jason S. , Eirug Ifan , Sideris Vasileios , Oliver Jon L. 
Published: January 2022

Abstract
Read, PJ, Pedley, JS, Eirug, I, Sideris, V, and Oliver, JL. Impaired stretch-shortening cycle function persists despite improvements in reactive strength followingafter anterior cruciate ligament reconstruction. J Strength Cond Res 36(5): 1238–1244, 2022—Reactive strength index (RSI) during a single-leg drop jump (SLDJ) has been indicated to determine return-to-sport readiness after anterior cruciate ligament (ACL) reconstruction, but only cross-sectional studies are available. Ground reaction force data and characterization of stretch-shortening cycle (SSC) function also remain sparse. Single-leg drop jump performance, ground reaction force, and SSC function were examined in soccer players with ACL reconstruction (n = 26) and matched controls (n = 25). Injured players were tested at 2 time points (32 and 42 weeks postsurgery). Stretch-shortening cycle function was classified as good (no impact peak and spring like), moderate (impact peak but still spring like or no impact peak and not spring like), or poor (impact peak and not spring like). The involved limb displayed lower-jump height, poorer RSI, less spring-like behavior, earlier peak landing force, and a greater ratio of landing peak to take-off peak force compared with the uninvolved limb and controls at the initial assessment (p < 0.001). Proportionally, more involved limbs were categorized as poor or moderate at the initial assessment (69.2%) and follow-up (50%) in comparison with the control limbs (14%). The reactive strength index was the only variable to change significantly between the initial assessment and follow-up on the involved limb (p < 0.05). No changes in the proportion of ACL reconstructed individuals categorized as poor or moderate SSC function at the follow-up assessment were observed. Residual deficits are present in SLDJ performance, SSC function, and ground reaction force characteristics after ACL reconstruction. The reactive strength index should not be the sole metric, as observed increases did not correspond with changes in SSC function.
The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model
Authors: Iwasawa Eri , Brown Farrah N. , Shula Crystal , Kahn Fatima , Lee Sang Hoon , Berta Temugin , Ladle David R. , Campbell Kenneth , Mangano Francesco T. , Goto June 
Published: January 2022

Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation and severe periventricular white matter damage in theprogressive hydrocephalus(prh) mutant which contains a point mutation in theCcdc39gene, causing loss of cilia-mediated unidirectional CSF flow. In this study, we identified cortical neuropil maturation defects such as impaired excitatory synapse maturation and loss of homeostatic microglia, and swimming locomotor defects in early postnatalprhmutant mice. Strikingly, systemic application of the anti-inflammatory small molecule bindarit significantly supports healthy postnatal cerebral cortical development in theprhmutant. While bindarit only mildly reduced the ventricular volume, it significantly improved the edematous appearance and myelination of the corpus callosum. Moreover, the treatment attenuated thinning in cortical Layers II–IV, excitatory synapse formation, and interneuron morphogenesis, by supporting the ramified-shaped homeostatic microglia from excessive cell death. Also, the therapeutic effect led to the alleviation of a spastic locomotor phenotype of the mutant. We found that microglia, but not peripheral monocytes, contribute to amoeboid-shaped activated myeloid cells inprhmutants' corpus callosum and the proinflammatory cytokines expression. Bindarit blocks nuclear factor (NF)-kB activation and its downstream proinflammatory cytokines, including monocyte chemoattractant protein-1, in theprhmutant. Collectively, we revealed that amelioration of neuroinflammation is crucial for white matter and neuronal maturation in neonatal hydrocephalus. Future studies of bindarit treatment combined with CSF diversion surgery may provide long-term benefits supporting neuronal development in neonatal hydrocephalus.SIGNIFICANCE STATEMENTIn neonatal hydrocephalus, little is known about the signaling cascades of neuroinflammation or the impact of such inflammatory insults on neural cell development within the perinatal cerebral cortex. Here, we report that proinflammatory activation of myeloid cells, the majority of which are derived from microglia, impairs periventricular myelination and cortical neuronal maturation using the mouseprhgenetic model of neonatal hydrocephalus. Administration of bindarit, an anti-inflammatory small molecule that blocks nuclear factor (NF)-kB activation, restored the cortical thinning and synaptic maturation defects in theprhmutant brain through suppression of microglial activation. These data indicate the potential therapeutic use of anti-inflammatory reagents targeting neuroinflammation in the treatment of neonatal hydrocephalus.
The Pandemic and Criminal Law – A Look at Theory and Practice in Germany
Authors: Lorenz Henning , Turhan Engin 
Published: January 2022

Abstract
This article provides an overview of the topic of the pandemic from the perspective of criminal law theory and practice in Germany. First of all, the major criminal offences of bodily injury and murder are discussed in the context of infecting a person with the Coronavirus and the (possible) consequences of having Covid-19, such as risk of death. The dilemmatic situation of triage, i.e., allocating limited intensive care resources, is illustrated in relation to the same offences. Then, the more specific crimes that came to the fore in the course of the pandemic are addressed. Subsidy fraud due to the state aids intended to compensate for the financial damage in the marketplace because of pandemic-related measures, and issuance or use of incorrect health certificates for exemption from the obligation to wear a face mask fall within this scope. Finally, the administrative offences law of the German Infection Protection Act was discussed, primarily with regard to regulations that violate the principle of legal certainty.
Selected Considerations Regarding the Digitalisation of Criminal Proceedings in Light of the Standards of the Council of Europe: Analysis Taking into Account the Experience of the Current Pandemic
Authors: Karski Karol , Oręziak Bartłomiej 
Published: January 2022

Abstract
The aim of the article is to prepare an analysis in order to formulate propositions regarding the digitalisation of Polish criminal proceedings as regards the administration of justice. These hypotheses would have merited consideration even pre-pandemic, but they demand even more attention as a result of the pandemic. The pandemic has served to highlight the pre-existing necessity to adapt criminal law to the latest observable technical and technological advances. In light of the above, the first issue to be analysed concerns the conditions, procedures, and possibilities surrounding the collection of evidence electronically, taking into account the most recent relevant guidelines of the Council of Europe. The second issue to be examined will be the adaptation of criminal procedures, including Polish, to the standards stipulated in the Convention of the Council of Europe on Cybercrime of 23 November 2001, in light of national norms regarding evidence gathering. The third issue that will be assessed in this study will be the benefits, risks, or potential of the application of artificial intelligence algorithms in criminal procedure. The consideration of each of the three areas will have regard to the present global pandemic. The article concludes with a concise summary containing the authors’ conclusions and propositions de lege ferenda.
The Impact of the Pandemic on Economic Crime
Authors: Pawluczuk-Bućko Paulina 
Published: January 2022

Abstract
This paper aims to outline possible directions of criminal activity that are part of both state and global economic crime. It is not a novelty that periods of economic crises carry particular criminogenic potential, affecting the scale and dynamics of specific crime categories. The ongoing pandemic makes precise data collection or statistical calculations, in the context of the problems described in this paper, difficult. Nevertheless, at this stage, it is possible to indicate certain areas which, from the perspective of criminal law, should be of interest for criminal law specialists, but also criminologists aiming to develop tools to combat the most serious pathologies in business trading.