bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS LECTORA INSPIRE MATERI TARI KREASI DAERAH
Authors: Lestari Wahyu Tri 
Published: August 2022

Tujuan dari penelitian ini adalah mengembangkan media pembelajaran berbasis lectora inspire yang layak dalam pembelajaran SBdP. Penelitian ini merupakan jenis penelitian Research and development (penelitian dan pengembangan) adaptasi dari Sugiyono, dengan langkah meliputi: potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, dan revisi produk. Adapun teknik pengumpulan data yang dilakukan adalah teknik nontes meliputi observasi, wawancara, angket,dan dokumentasi. Subjek penelitian ini adalah siswa kelas IV SDN 4 Sukorejo berjumlah 24 siswa. Hasil penelitian menunjukkan bahwa media pembelajaran berbasis lectora inspire dinyatakan layak oleh ahli materi dan ahli media dengan persentase komponen kelayakan isi materi oleh ahli materi 1 dan 2 yaitu 76,25% dan 75% dengan kriteria layak dan komponen penyajian media oleh ahli media 1 dan ahli media 2 yaitu 92,18% dan 96,87% dengan kriteria sangat layak. Simpulan penelitian ini adalah media pembelajaran berbasis lectora inspire pada muatan SBdP layak digunakan dalam pembelajaran SBdP pada materi tari kreasi daerah.
The purpose of this study is to develop appropriate lectora inspire-based learning media in SBdP learning. This research is a type of research and development (research and development) adaptation of Sugiyono, with steps including: potentials and problems, data collection, product design, design validation, design revision, and product revision. The data collection technique used is non-test techniques including observation, interviews, questionnaires, and documentation. The subjects of this study were 24 students of grade IV SDN 4 Sukorejo. The results showed that the lectora inspire-based learning media was declared feasible by material experts and media experts with the percentage of material content feasibility components by material experts 1 and 2, namely 76.25% and 75% with appropriate criteria and media presentation components by media experts 1 and experts. Media 2, namely 92.18% and 96.87% with very feasible criteria. The conclusion of this research is that learning media based on lectora inspire on SBdP content is suitable for use in SBdP learning on regional creation dance material.
KEEFEKTIFAN MODEL CIRC BERBANTUAN PAPAN SELIP TERHADAP PENGUASAAN KOSAKATA SISWA KELAS III
Authors: Khusna Viki Azimatul 
Published: August 2022

Abstrak
Penelitian ini bertujuan untuk menguji keefektifan model cooperative integrated reading and composition (CIRC) berbantuan media papan selip terhadap penguasaan kosakata siswa.Penelitian ini mengguna-kan metode kuantitatif. Jenis penelitian ini adalah penelitian eksperimen dengan desain pene-litian quasi experimental. Prosedur penelitian menggunakan non equivalent control group de-sign. Populasi penelitian ini adalah siswa kelas III SD di Gugus Wolter Monginsidi. Teknik pengambilan sampel adalah cluster random sampling dengan SDN 02 Mororejo sebagai kelas eksperimen dan SDN 03 Sarirejo sebagai kelas kontrol. Pengumpulan data menggunakan tek-nik tes, observasi, wawancara, dan dokumentasi. Hasil uji hipotesis menggunakan Indepen-dent Sample T-Test menunjukan bahwa nilai ð‘¡â„Žð‘–ð‘¡ð‘¢ð‘›ð‘” (4,569) > ð‘¡ð‘¡ð‘Žð‘ð‘’ð‘™ (1,9967), artinya hasil tes yang di-peroleh kelas eksperimen lebih besar dibandingkan kelas kontrol. Hail ini di-dukung dengan hasil uji N-gain, yaitu kelas eksperimen berada pada kriteria sedang (0,39) dan kelas kontrol berada pada kriteria rendah (0,25). Observasi aktifitas siswa menunjukan rata-rata kelas eksperimen lebih tinggi yaitu 82,50% dibandingkan kelas kontrol yaitu 76,56%. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa model pembelajaran CIRC berbantuan media papan selip efektif terhadap peningkatan penguasaan kosakata dan aktivitas siswa kelas III SD di Gugus Wolter Monginsidi.
This study aims to test the effectiveness of cooperative integrated reading and composition (CIRC) models assisted by slot board media on the studentâ€™s vocabulary mastery. This experiment used quantitative method. The kind of this experimen is quasi experimental desaign. The prosedure of the experiment used non-equivalent control group design. The population of this experiment is the third grade of elementary school in Gugus Wolter Monginsidi. The technique of taking sample is cluster random sampling with SDN 02 Mororejo as experimental class and SDN 03 Sarirejo as control class. Data collection used test technique, observation, interview and documentation techniques. The result of hypothesis used independent sample T-test offers that the score of ð‘¡count (4,569) >ð‘¡ð‘¡ð‘Žð‘ð‘’ð‘™ (1,9967), it means the test results of the experimental class bigger than the control class. This was supported with the result of the N-Gain test, that is the experimental class was in medium criteria (0,424) and the control class was in low criteria (0,233). Observation of studentâ€™s activity refers to average of experiment class is higher that is 82,50% if compared with control class that is 76,56%. Based on the research results, it can be concluded that CIRC learning model assisted by slot board media is effective in improving vocabulary mastery and students activities at the third grade of elementary schools in Gugus Wolter Monginsidi.
NETest: serial liquid biopsies in gastroenteropancreatic NET surveillance
Authors: van Treijen Mark J C , Korse Catharina M , Verbeek Wieke H , Tesselaar Margot E T , Valk Gerlof D 
Published: August 2022

Objective
Up to now, serial NETest measurements in individuals assessing the disease course of gastroenteropancreatic neuroendocrine tumors (GEPNETs) at long-term follow-up and treatment response were not studied.

Design
The study was a longitudinal validation study of serial NETest measurements – a blood-based gene expression signature – in 132 patients with GEPNETs on therapy or watch-and-wait strategy.

Methods
Serial samples were collected during 46 (range: 6–71) months of follow-up. NETest scores were compared with Response Evaluation Criteria in Solid Tumors version 1.1-defined treatment response (e.g. no evidence of disease (NED), stable disease (SD) or progressive disease (PD)).

Results
Consecutive NETest scores fluctuated substantially (range: 0–100) over time in individuals with SD (n = 28) and NED (n = 30). Follow-up samples were significantly higher in SD (samples 3–5) and NED subgroups (samples 2–5) compared with baseline results, without changes in imaging. In 82% of untreated patients with PD, consecutive NETest scores consistently remained high. In patients undergoing systemic treatment, the median pre-treatment NETest score in treatment-responders was 76.5 (n = 22) vs 33 (n = 12) in non-responders (P = 0.001). Patients with low pre-treatment scores had 21 months reduced progression-free survival (10 vs 31 months; P = 0.01). The accuracy of the NETest for treatment response prediction was 0.73 (P = 0.009).

Conclusion
In patients not undergoing treatment, consecutive low NETest scores are associated with indolent behavior. Patients who develop PD exhibit elevated scores. Elevated results have important predictive value for treatment responsiveness and could be used for individualizing decisions on systemic therapy. The clinical value of follow-up NETest scores for patients who choose to watch and wait requires further study.
Rapid ovarian transcript changes during the onset of premature ovarian insufficiency in a mouse model
Authors: Kaune Heidy , Montiel Juan F , Fenwick Mark , Williams Suzannah A 
Published: August 2022

Premature ovarian insufficiency (POI) affects 1-3% of women under 40 years of age. The identified causes are highly heterogeneous, and 70% of the cases are idiopathic. The ovarian manifestation varies from a variable population of follicles that fail to develop (follicular POI) to the absence of follicles (afollicular POI) with a transition from one to the other over time. Previously, we have described a mouse model of POI that results from an oocyte-specific deletion of N- and O-glycans; Double Mutant (DM). DM females produce only one litter before undergoing POI due to ovarian dysfunction. In this study, we have characterised the gene expression profile of prepuberal (3 weeks), fertile (6 weeks) and infertile (9 weeks) DM ovaries. Up-regulation of cathepsin K (Ctsk, with unknown ovarian function) seems to trigger transcriptional changes in DM ovaries. Significant transcriptional changes then occur rapidly, associated with morphophysiological changes displayed by DM mice throughout the onset of POI. We identified genetic pathways such as extracellular matrix and immune response as candidates for the onset of POI in DM females. Remarkably, DM mice and POI women share a set of differentially expressed genes, including a functionally and co-expressed network of Mcm (minichromosome maintenance proteins) family members. The transcriptomic profile of the DM mouse model provides novel insight into the aetiology of POI.

Lay summary
Problems in ovary function lead to reduced fertility or infertility. One such condition is premature ovarian insufficiency (POI) which affects 1% of women under 40 years of age, and in over 70% of these, the cause of POI is unknown. To investigate POI, we have developed a mouse model. These mice are initially fertile but develop POI by 3 months of age. In this study, we investigated the changes in genes activated in the ovaries during the transition from fertility to POI, and we did this by comparing them to normal mice; gene activation leads to molecule production. A molecule known as cathepsin K seems to trigger changes during the onset of POI, followed by others related to structure and immune response pathways. In addition, some genes were identified that are similar between the POI mice and POI women.
Supraglottic Airways Compared With Face Masks for Neonatal Resuscitation: A Systematic Review
Authors: Yamada Nicole K. , McKinlay Christopher JD , Quek Bin Huey , Schmölzer Georg M. , Wyckoff Myra H. , Liley Helen G. , Rabi Yacov , Weiner Gary M. 
Published: August 2022

BACKGROUND AND OBJECTIVES
Positive pressure ventilation (PPV) is the most important component of neonatal resuscitation, but face mask ventilation can be difficult. Compare supraglottic airway devices (SA) with face masks for term and late preterm infants receiving PPV immediately after birth

METHODS
Data sources include Medline, Embase, Cochrane Databases, Database of Abstracts of Reviews of Effects, and Cumulative Index to Nursing and Allied Health Literature. Study selections include randomized, quasi-randomized, interrupted time series, controlled before-after, and cohort studies with English abstracts. Two authors independently extracted data and assessed risk of bias and certainty of evidence. The primary outcome was failure to improve with positive pressure ventilation. When appropriate, data were pooled using fixed effect models.

RESULTS
Meta-analysis of 6 randomized controlled trials (1823 newborn infants) showed that use of an SA decreased the probability of failure to improve with PPV (relative risk 0.24; 95% confidence interval 0.17 to 0.36; P &lt;.001, moderate certainty) and endotracheal intubation (4 randomized controlled trials, 1689 newborn infants) in the delivery room (relative risk 0.34, 95% confidence interval 0.20 to 0.56; P &lt;.001, low certainty). The duration of PPV and time until heart rate &gt;100 beats per minute was shorter with the SA. There was no difference in the use of chest compressions or epinephrine during resuscitation. Certainty of evidence was low or very low for most outcomes.

CONCLUSIONS
Among late preterm and term infants who require resuscitation after birth, ventilation may be more effective if delivered by SA rather than face mask and may reduce the need for endotracheal intubation.
Participation in subsistence activities and maintenance of traditional skills among indigenous youth in the South Rupununi, Guyana
Authors: Van Vliet Nathalie , Millar Neal , Melville Alyssa , David Oswin , Ignacio Leroy 
Published: August 2022

Over the past few decades, issues including globalization and the transition to the cash economy have increasingly hindered the transmission of Traditional Ecological Knowledge (TEK) in Indigenous communities throughout the world. The imparting of TEK across generations of Indigenous Peoples is essential in sustaining cultural practices and to maintaining their subsistence lifestyles. In this study, we used semi-structure interviews to assess the level of participation in subsistence activities and acquisition of subsistence skills among Indigenous children in Guyana. We also assessed whether the level of participation or acquisition of skills was explained by location and social characteristics such as age, gender, occupation of mother/father. We found that Indigenous children in the South Rupununi are highly involved in subsistence activities and the majority conserves subsistence related skills. Traditional gears, such as the bow and arrow are still dominant among Indigenous children in South Rupununi, particularly for hunting purposes, but also for fishing. Results also suggest that children’s participation (through work or play) in subsistence activities are key to the acquisition of subsistence knowledge and skills. Among indigenous children in South Rupununi, participation to subsistence activities varies according to gender and is linked to the main occupation of the parents. While participation in subsistence activities is primarily motivated by the need to search for food, those activities are also explicitly described as providing opportunities for skill development and as sources of fun or amusement. The study concludes by advocating the need to revive connections to subsistence ways of life and the integration of more situated learning experiences within the regular school curriculum for indigenous youth.
Технології створення High-Poly моделей у пакеті Blender 3D
Authors: Бойцова М. , Ломовцев П. Б. , Бойцова О. С. 
Published: August 2022

У роботі розглянуто процес розробки асетів для комп’ютерних ігор за професійним пайплайном, етапи моделювання та текстурування, акцентовано увагу на технологіях OpenGL та PBR. В роботі пропонується оптимальне поєднання технологій та програмних засобів для створення якісного проекту для подальшого використання як унікальних ігрових об’єктів. Особливу увагу приділено питанню оптимізації моделей на етапі роботи з сіткою, розлянуто ряд автоматичних засобів і виконано порівняння в ефективності з ручними методами. З метою прискорення роботи та економії цифрових ресурсів виконується ряд технічних задач : виконання ретопології, розгортки моделей, запечення карт нормалей. Продемонстровано технології високоякісного рендерингу в реальному часі для створення фінальної демонстрації готових асетів.
Дослідження методів соціальної інженерії. Частина I. Вплив на здоров’я людини.
Authors: Селіванова А. В. , Левитський Ю. О. 
Published: August 2022

Представлена робота присвячена дослідженню впливу методів соціальної інженерії (СІ) на здоров’я людини.
В процесі роботи досліджено визначення терміну соціальна інженерія, його популярність, алгоритм дії соціальних інженерів (СІн), методи впливу СІ на людину, види агресивного психологічного впливу на особистість у кіберпросторі, засоби подолання наслідків впливу методів СІ на людину, інформаційні системи, що інформують про методи СІ та їх вплив на здоров’я людини.
Проведено збір даних методом опитування, що характеризує вплив дії СІн на здоров’я людей. Отримані дані оброблені за допомогою засобів інтелектуального аналізу даних із використанням інструментальних засобів Google та Orange. Розроблено модель впливу СІ на здоров’я людини.
Результати дослідження було впроваджено у аналітичну платформу KitStat у якості оновлення, що дозволяє надати інформаційну підтримку та забезпечити продовження збору даних для подальшого дослідження.
В процесі проведення дослідження використано такі засоби та технології як Google Forms, Google Analytіcs, Orange, мови HTML5, CSS3, PHP, JavaScript.
Результати дослідження можуть бути використані як фахівцями при дослідженні методів СІ так і звичайними людьми для захисту від дії соціальних інженерів.
Factors associated with the intermediate probability of heart failure with preserved ejection fraction on the H<sub>2</sub>FPEF score in asymptomatic patients in rotation work conditions in the Arctic
Authors: Vetoshkin A. S. , Shurkevich N. P. , Simonyan A. A. , Gapon L. I. , Kareva M. A. 
Published: August 2022

Aim. To study the factors associated with the intermediate probability of heart failure (HF) with preserved ejection fraction (HFpEF) according to the H2FPEF score (Heavy; Hypertensive; Atrial Fibrillation; Pulmonary Hypertension; Elder; Filling Pressure) in asymptomatic patients in rotation work conditions in the Arctic.Material and methods. In the polar village of Yamburg (68° 21’ 40” northern latitude), 100 men and 80 women with grade 1, 2 hypertension and normotensive persons were examined on the basis of the Medical Unit of OOO Gazprom Dobycha Yamburg. All patients underwent echocardiography using generally accepted methods of imaging and data processing, according to European Society of Echocardiography guidelines. To calculate the probability of HFpEF, the H2FPEF score was used. The Bruce protocol treadmill test was performed. The SF-36 (Health Status Survey) questionnaire for assessment of life quality was used.Results. Group 1 included 95 male and female patients with a low probability of HF (H2FPEF score — 0-1), group 2 — 85 patients of both sexes with an intermediate probability of HF (H2FPEF score — 2-5). Group 2 patients were older (p=0,038), worked longer on a shift (p=0,0143), and had higher ambulatory systolic (p=0,0001) and diastolic blood pressure (p=0,0013) with a higher body mass index (BMI) (p=0,0001). Based on the odds ratio (OR) analysis, the factor most strongly influencing the intermediate probability of HFpEF was BMI (OR=1,261, 95% confidence interval (CI): 1,140-1,393). SF-36 questionnaire revealed intergroup differences only on the role functioning scale (p=0,013) with lower values in group 2. In the logistic regression model, dyspnea during the treadmill test occupied a leading position as follows: OR=8,952; 95% CI: 3,454-15,197 (p<0,0001). The second place was taken by inotropic reserve value (OR=1,020; 95% CI: 1,006-1,035 (p=0,005), which was higher in group 2 and was regarded as one of the compensatory mechanisms for adapting to stress. In the group 2, echocardiography revealed significant differences in terms of left ventricular (LV) myocardial mass (p=0,0002), LV internal area (p=0,0002), isovolumic relaxation time (p=0,003), and ratio of transmitral diastolic flow rate to mean mitral annulus velocity (p=0,0001), which indirectly indicates the presence of LV diastolic dysfunction.Conclusion. There are following factors associated with H2FPEF intermediate probability of HFpEF in asymptomatic patients on shift in the Arctic: BMI, length of shift, dyspnea and an increase in inotropic reserve during exercise due to a decrease in adaptive potential, impaired LV diastolic function. Initiating management strategies that target identified factors in patients with asymptomatic HF may slow symptomatic disease progression in shift workers in the Arctic region.
Prevalence of myocarditis, genetic cardiomyopathies and their combinations among patients of the Cardiology Hospital of the V.N. Vinogradov Faculty Therapeutic Clinic of the Sechenov University
Authors: Ruchkin D. V. , Nartova A. A. , Zaitseva A. I. , Lutokhina Yu. A. , Blagova O. V. , Alijeva I. N. , Sarkisova N. D. , Nedostup A. V. 
Published: August 2022

Aim. To establish the prevalence of myocarditis and primary (genetic) cardiomyopathies (CMP) among patients in a cardiology hospital.Material and methods. Medical records of 671 patients of the cardiology department were analyzed. The diagnosis at admission and at discharge was recorded. The diagnoses were divided into 7 following categories: hypertension, coronary artery disease, heart disease, idiopathic arrhythmias, cardiomyopathy, myocarditis and others. Types of myocarditis and cardiomyopathy, the presence of arrhythmias and heart failure were also recorded.Results. Myocarditis was diagnosed in 194 (28,9%) patients, cardiomyopathy — in 76 (11,3%) patients, combination of cardiomyopathy and myocarditis — in 26 (3,9%) patients. Myocarditis with the development of arrhythmia and heart dilatation prevailed as follows: 47,4 and 41,2%, respectively. The most numerous CMPs were left ventricular noncompaction (n=30), non-inflammatory dilated CMP (n=13), hypertrophic CMP (n=10) and arrhythmogenic CMP of the right ventricle (n=9). In the group with idiopathic arrhythmias, 64,3% of patients were diagnosed with myocarditis, and 19,4% — with cardiomyopathy.Conclusion. The prevalence of non-coronary myocardial diseases among patients in a cardiology hospital is high and amounts to 40,2%. The presence of arrhythmias, heart failure or dilated cardiomyopathy may be a manifestation of non-coronary myocardial diseases, and requires a comprehensive examination aimed, in particular, at ruling out or verifying the diagnosis of myocarditis.
Comparative retrospective analysis of the prevalence of deep vein thrombosis detected by duplex ultrasound in primary health care facilities
Authors: Rozykhodzhaeva G. A. , Zhuraev Z. A. 
Published: August 2022

Aim. To identify the incidence of deep vein thrombosis (DVT) as determined by compressive duplex ultrasound in primary health care facilities before and during the pandemic of a coronavirus disease 2019 (COVID-19).Material and methods. This retrospective analysis of 1492 duplex ultrasound examinations in 2018 and 1710 examinations in 2020-2021 in patients with suspected lower limb DVT was performed. The studies were carried out in 4 primary health care institutions in different cities of the Republic of Uzbekistan. Each patient underwent duplex ultrasound of lower limb deep veins. Most patients had complaints (swelling, leg pain) (symptomatic patients), while some individuals underwent preventive screening before various surgical interventions and had no complaints (asymptomatic patients).Results. According to the data obtained, the prevalence of DVT increased significantly during the pandemic — from 3,9 to 15,1% (χ2=113,23, p<0,001). During the pandemic, there was a trend towards a relative increase in lower limb DVT among the elderly and young people — by 8,7 and 3,8%, respectively (χ2=1,66, p=0,19 and χ2=0,64, p=0,42, respectively). No dependence of the prevalence of lower limb DVT on the sex was found (χ2=0,02, r=0,9).Conclusion. The study results showed an increase in the prevalence of lower limb DVT during the COVID-19 pandemic. Further clinical studies are needed to analyze the lower limb DVT during this period.