bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roadside infrastructure deployment scheme based on Internet of Vehicles information service demand
Authors: Mao Ming , Yi Peng , Hu Tao 
Published: October 2022

AbstractRoadside unit (RSU) plays an important role in communication relay and data processing in the Internet of Vehicles. The rational deployment of roadside units directly affects the operational efficiency and system robustness of the Internet of Vehicles. This article proposes an RSU deployment scheme based on vehicular transmission demand. First, the mobility model of vehicles is mined through system communication transmission requirements to determine the total delay of vehicle communication transmission tasks. The delay includes two parts, namely, the vehicle data transmission delay and the channel service delay. Second, the optimization objective of the model is established, and some parameters such as inhibition distance coefficient are defined as constraint conditions. Finally, a evolutionary feature‐based RSU deployment algorithm, ICA‐EFRDA, preprocessed by a greedy algorithm is proposed to implement RSU deployment. The deployment results show that the proposed scheme has lower delay and higher coverage time ratio than the EFRDA scheme in both urban and suburban road networks. Under limited cost constraints, the system decides to place a limited number of RSUs in low‐traffic density areas of the suburban road network to improve performance. When the traffic density is high, the increased placement of RSUs in the urban road network has a more obvious effect on improving the service capability of the system. Under different deployment cost constraints, ICA‐EFRDA outperforms the comparison schemes in terms of the contacts per trip, contact probability, and packet delivery ratio.
Prevalence of elective cosmetic surgery and its relationship with socioeconomic and mental health: A cross‐sectional study in west of Iran
Authors: Ghorbani Ahoora , Piroozi Bakhtiar , Safari Hossein , Shokri Azad , Aqaei Abbas , Yousefi Fayegh , Nikouei Maziar , Rafieemovahhed Mahdi 
Published: October 2022

AbstractBackground and AimsThe aim of this study was to investigate the prevalence and desire towards performing elective cosmetic surgery and its relationship with socioeconomic, mental, and spiritual health in Sanandaj, the capital of Kurdistan province in the west of Iran.MethodsThis cross‐sectional descriptive‐analytical study was performed on 492 subjects in Sanandaj using multistage sampling method. Data collection tools included two checklists and two questionnaires. Data analysis was performed using the Chi‐square test and multiple logistics regression model by the help of SPSS software version 20.ResultsThe mean (standard deviation) age of participants was 32.58 (9.67) years. The prevalence of cosmetic surgery and the desire to perform it were 12.8% (n = 63) and 19.1% (n = 94), respectively. The most common type of cosmetic surgery was rhinoplasty with 5.5% (n = 27). The prevalence of symptoms of mental disorders among people with cosmetic surgery and people willing to perform cosmetic surgery was significantly higher than all subjects (p < 0.001). Female gender (odds ratio [OR] = 1.98; 95% confidence interval [CI]: 1.06–3.68) and having mild (OR = 3.01 95% CI: 1.06–3.68) and moderate to severe symptoms of mental disorder (OR = 7.59; 95% CI: 3.90–14.75) were among the influential variables on performing cosmetic surgery.ConclusionBoth the prevalence and desire towards performing cosmetic surgery are high in Sanandaj and this needs the attention of health policy makers. Designing targeted interventions with an emphasis on the findings of this study is proposed to reduce these practices.
The effect of selective serotonin and norepinephrine reuptake inhibitors on clinical outcome of COVID‐19 patients: A systematic review and meta‐analysis
Authors: Firouzabadi Dena , Kheshti Fatemeh , Abdollahifard Saeed , Taherifard Erfan , Kheshti Mohammad Reza 
Published: October 2022

AbstractBackground and AimDue to the high social and economic burden and also mortality and morbidity caused by coronavirus disease 2019 (COVID‐19) in the past few years, researchers have aimed at finding solutions to suppressing the severity of infection. Recently, selective serotonin and serotonin‐norepinephrine reuptake inhibitors (SSRI/SNRI) have been investigated as an adjuvant treatment for COVID‐19. The aim of the current study was to investigate the impact of SSRI/SNRIs on outcomes of COVID‐19 patients.MethodsIn this systematic review and meta‐analysis, a comprehensive search strategy consisting of relevant words was performed by two researchers in PubMed, Scopus and EMBASE libraries. Studies reporting the effect of SSRI and/or SNRI use in COVID‐19 patients' outcome were included. Hospitalization, mortality, hospitalization event, and length of hospital stay were considered as main outcomes of this study. Analysis was carried out using Comprehensive Meta‐Analysis (CMA‐version 2) and final data were reported as odds ratio (OR) and 95% confidence interval (CI).ResultsOur search led to the final selection of 9 articles including 15,287 patients. The effect of fluvoxamine, fluoxetine, and the overall effect of SSRI/SNRI use on mortality of COVID‐19 patients were investigated in 3, 2, and 7 articles, respectively. The results of our analyses showed that these medications could significantly decrease mortality of COVID‐19 patients (OR and 95% [CI]: 0.595 [0.467–0.758], 0.620 [0.469–0.821], and 0.596 [0.437–0.813]). The effect of SSRI/SNRIs on hospitalization events of COVID‐19 patients was not significant (OR: 0.240% and 95% CI: 0.041–1.4). Also, length of hospital stay was longer in patients who administrated SSRIs.ConclusionAccording to this study's results, SSRI/SNRIs may be effective in reducing mortality of COVID‐19 patients, suggesting the superiority of fluvoxamine to fluoxetine. The safety profile and affordable cost of SSRI/SNRIs for a short‐term use may be other reasons to propose them as beneficial medications in preventing mortality in COVID‐19.
Self‐care behavior prevention of COVID‐19 in the general population based on Pender Health Promotion Model: A cross‐sectional study
Authors: Pouresmali Asghar , Dargahi Shahriar , Alizadehgoradel Jaber , Kamran Aziz , Fathi Davod , Molaei Behnam 
Published: October 2022

AbstractBackground and AimsCoronavirus with its sudden and widespread outbreak has obviously imposed devastating consequences in various aspects of human life. The purpose of this study was to determine the predictive value of Pender's Health Promotion Model (HPM) structures in self‐care preventive behavior against coronavirus disease 2019 (COVID‐19) among the general population of Ardabil, Iran.MethodsThe present retrospective descriptive‐correlational study was conducted on citizens of Ardabil aged 18 years and over in 2021. After dividing the city of Ardabil into four parts, 50 people from each area of the city and a total of 200 people were selected through the available sampling method through social media. Data collection tools included a demographic profile, perceived self‐efficacy scale, perceived emotional questionnaire, perceived social support questionnaire, perceived benefits and barriers questionnaire, researcher‐made COVID‐19 self‐care questionnaire, and commitment to action questionnaire based on Pender's HPM structures in an online manner. Data were analyzed by Amos 22 software and using structural equation modeling.ResultsAccording to the results, direct path analysis to COVID‐19 self‐care behavior indicated that the variables of perceived self‐efficacy (β = 0.18, p < 0.01), interpersonal effects (β = 0.19, p < 0.01), positive emotion (β = 0.15, p < 0.05) and perceived benefits (β = 0.20, p < 0.01) are able to significantly predict self‐care behaviors. Moreover, the bootstrapping test results in the indirect path analysis demonstrated that the variables of perceived self‐efficacy (95% confidence interval [CI], 0.012, 0.066), perceived social support (95% CI, 0.002, 0.026), and perceived barriers (95% CI, −0.019, −0.002) and benefits (95% CI, 0.001, 0. 015) through the mediator variable of commitment to action are able to significantly predict COVID‐19 self‐care behavior.ConclusionsBased on the findings of the present study, it can be claimed that the proposed model of COVID‐19 self‐care behavior has an acceptable fitness in the general population. This model can be used in developing educational programs and intervention techniques to modify people's attitudes and behaviors.
Climate change vulnerability, and health of women and children: Evidence from India using district level data
Authors: Mahapatra Bidhubhusan , Chaudhuri Trisha , Saggurti Niranjan 
Published: October 2022

AbstractObjectiveTo understand how climate change vulnerability is associated with women and children's health (WCH) at the district level in India.MethodsThe district‐specific climate change vulnerability index was mapped to the district level NFHS‐5 data (N = 674). Fractional regression and spatial analyses were performed to examine the strength of association and the presence of geographic clustering.ResultsBivariate analysis revealed that the levels of WCH indicators were lower in districts with a high vulnerability index than in those with a low vulnerability index. Multivariable analyses suggested that with a 1% increase in the vulnerability index, the proportion of modern contraceptive use was reduced by 0.22, four or more prenatal care visits by 0.14, postnatal care by 0.11, and full immunization by 0.12; whereas wasting and underweight proportions increased by 0.07 and 0.10, respectively. The spatial analysis found that in about 70–118 districts, mostly in eastern India, where climate vulnerability was high the WCH outcomes were also poor.ConclusionThere is a macro‐level association between climate change vulnerability and WCH, as districts that had high levels of climate change vulnerability also performed poorly in WCH. There is a need for an integrated approach that considers geography‐specific climate change threats to develop health programs.
Content development and initial psychometric analysis of the problematic hypersexuality scale
Authors: Oberheim S. Tyler , DePue M. Kristina , Liu Ren 
Published: October 2022

AbstractThe purpose of this investigation was to develop an instrument to screen for the presence of problematic hypersexuality in a nonclinical sample of 357 adults residing in the United States. The problematic hypersexuality scale (PHS) was the product of this investigation and was designed to address the limitations of existing measures for this construct and gather psychometric evidence to support the intended uses of and claims drawn from this instrument. Empirical evidence for the use of the PHS as a screener was founded through factor analytic procedures, Rasch modeling, and the use of item response theory.
Preparation and characterization of ternary composite rGO/Fe3O4/CdS and evaluating its efficiency in photodegradation of crystal violet dye
Authors: Alwan Duhak A. , Hatem Oraas A. 
Published: October 2022

AbstractReduced graphene oxide/Iron Oxide/cadmium sulfide rGO‐Fe3O4‐CdS nanocomposite with magnetic properties was obtained using the chemical deposition method. The synthesized nanocomposite's structural, chemical, morphology, and surface properties were investigated by many characterization techniques including T.E.M., XRD, FE‐SEM, Raman, D.R.S. and BET‐BJH. The energy gap of synthesized Nanocomposite was (1.651 eV) for ternary composite compared to (2.42 eV) for the pure nano cadmium sulfide. The prepared composites' photocatalytic ability was studied using the photodegradation process of crystal violet dye under visible light irradiation. Under optimal conditions, the photodegradation efficiency of the dye was 95.4% using the ternary composite and 30% using pure nano cadmium sulfide.
Organizational cultures that support community: Does the competing values framework help us understand experiences of community at work?
Authors: Boyd Neil M. , Larson Sharon 
Published: October 2022

AbstractRecent evidence has shown that when employees experience perceptions of community at work (i.e., a sense of community and a sense of community responsibility), psychological well‐being and behavioral engagement improve (e.g., greater job engagement, organizational citizenship, and leadership). Recent evidence also shows that experiences of community, as a motivational state, are better able to predict employee outcomes compared to a series of factors that have long been studied in the general management (i.e., affective organizational commitment, organizational identity) and in the public management literature (i.e., public service motivation). However, we know less about the conditions that lead to perceptions of community experiences at work. One recent qualitative investigation exposed a series of organizational conditions that appear to stimulate perceptions of community at work including C‐Suite leadership support, organizational structure and context, characteristics of connection, managerial, job, and work unit characteristics, and responsibilities of human resource management professionals. The present study extends this study by empirically investigating organizational cultural conditions that are associated with perceptions of community at work. We test the ability of the Competing Values Framework, which includes constructs of Hierarchy, Market, Adhocracy, and Clan organizational cultures, and their ability to predict perceptions of the community. Findings showed that clan culture was most associated with perceptions of community in general and that clan culture within a department plays an important role in perceiving community at work. This study helps scholars understand cultural conditions that can lead to psychological experiences of community, it begins to frame cultural factors that scholars can empirically test in future studies, and it assists executives and managers in conceiving approaches to building cultures of community at work.
Precise A∙T to G∙C base editing in the allotetraploid rapeseed (Brassica napus L.) genome
Authors: Hu Limin , Zhai Yungu , Xu Lei , Wang Jingzhen , Yang Shangpo , Sun Yunxia , Yu Kaidi , He Hanzi , Fan Chuchuan 
Published: October 2022

AbstractRapeseed is an important source of oilseed crop in the world. Achieving genetic improvement has always been the major goal in rapeseed production. Single nucleotide substitution is the basis of most genetic variation underpinning important agronomic traits. Nowadays, Cas‐base editing acts as an efficient tool to mediate single‐base substitution at the target site. In this study, four adenine base editors (ABE) were modified to achieve adenosine base editing at different genome sites in allotetraploid Brassica napus. We designed 18 small guide RNAs to target phytoene desaturase (PDS), acetolactate synthase (ALS), CLAVATA3 (CLV3), CLV2, TRANSPARENT TESTA12 (TT12), carotenoid isomerase (CRTISO), designated de‐etiolated‐2 (DET2), BRANCHED1 (BRC1), zeaxanthin epoxidase (ZEP) genes, respectively. Among the four ABE systems, pBGE17 had the highest base‐editing efficiency, with an average editing efficiency of 3.51%. Target sequencing results revealed that the editing window ranged from A5 to A8 of the protospacer‐adjacent motif (PAM) sequence. Moreover, the ABEmax‐nCas9NG system with NG PAM was developed, with a base‐editing efficiency of 1.22%. These results revealed that ABE system developed in this study could efficiently induce A to G substitution and the ABE‐nCas9NG system could broaden editing window in oilseed rape.
A density bound for triangle‐free 4‐critical graphs
Authors: Moore Benjamin , Smith‐Roberge Evelyne 
Published: October 2022

AbstractWe prove that every triangle‐free 4‐critical graph satisfies . This result gives a unified proof that triangle‐free planar graphs are 3‐colourable, as well as that graphs of girth at least five which embed in either the projective plane, torus or Klein Bottle are 3‐colourable, which are results of Grötzsch, Thomassen, and Thomas and Walls. Our result is nearly the best possible, as Davies has constructed triangle‐free 4‐critical graphs such that . To prove this result, we prove a more general result characterizing sparse 4‐critical graphs with few vertex‐disjoint triangles.
Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates
Authors: Sahu Chandrakant , Chaurasiya Abhishek , Chawla Pooja A. 
Published: October 2022

AbstractCancer is a broad word for a set of diseases that can begin in virtually any organ or tissue of the body and spread to other organs. In 2020, cancer was the largest cause of death worldwide, accounting for 10 million fatalities, or one in every six deaths. Nitrogen containing heterocyclic compounds are a massive research focus because it has a unique position and is a cherished source of a wide range of bioactive molecules in medicinal chemistry. Over 75% of the currently accessible market is covered by FDA‐approved drugs containing nitrogen moieties. DNA topoisomerase II is a reassuring approach for novel anticancer heterocyclic medicines because it plays a crucial role in DNA metabolism, replication, recombination, and repair. Given the importance of topo II in chemotherapy, there is a pressing necessity to boost topo II or multi‐target topo II inhibitors in order to combat drug resistance and minimize toxicity. Following the trend of researching the advancement of effective topo II inhibitors with minimal toxicity, the current review article consolidates a detailed account of nitrogen‐containing heterocyclic compounds and categorizes them into different classes based on structural characterization, such pyrimidine, triazine, pyridine, quinazoline, fluoroquinolones, quinones, pyrazoles, quinoline, carbazoles, β‐carboline, quinolone, naphthalimide, acridone, benzoxazole, pyridophenoxazine, pyrrole, piperazine and imidazole, along with their structure activity relationship, mechanistic aspects, and docking studies (wherever appropriate) were explored. We are certain that the current review paper will help future medical researchers investigate prospective topoisomerase inhibitors as anticancer medicines in a variety of clinical settings.
Sex‐specific newborn screening for X‐linked adrenoleukodystrophy
Authors: Albersen Monique , van der Beek Samantha L. , Dijkstra Inge M. E. , Alders Mariëlle , Barendsen Rinse W. , Bliek Jet , Boelen Anita , Ebberink Merel S. , Ferdinandusse Sacha , Goorden Susan M. I. , Heijboer Annemieke C. , Jansen Mandy , Jaspers Yorrick R. J. , Metgod Ingrid , Salomons Gajja S. , Vaz Frédéric M. , Verschoof‐Puite Rendelien K. , Visser Wouter F. , Dekkers Eugènie , Engelen Marc , Kemp Stephan 
Published: October 2022

AbstractMales with X‐linked adrenoleukodystrophy (ALD) are at high risk for developing adrenal insufficiency and/or progressive leukodystrophy (cerebral ALD) at an early age. Pathogenic variants in ABCD1 result in elevated levels of very long‐chain fatty acids (VLCFA), including C26:0‐lysophosphatidylcholine (C26:0‐LPC). Newborn screening for ALD enables prospective monitoring and timely therapeutic intervention, thereby preventing irreversible damage and saving lives. The Dutch Health Council recommended to screen only male newborns for ALD without identifying untreatable conditions associated with elevated C26:0‐LPC, like Zellweger spectrum disorders and single peroxisomal enzyme defects. Here, we present the results of the SCAN (Screening for ALD in the Netherlands) study which is the first sex‐specific newborn screening program worldwide. Males with ALD are identified based on elevated C26:0‐LPC levels, the presence of one X‐chromosome and a variant in ABCD1, in heel prick dried bloodspots. Screening of 71 208 newborns resulted in the identification of four boys with ALD who, following referral to the pediatric neurologist and confirmation of the diagnosis, enrolled in a long‐term follow‐up program. The results of this pilot show the feasibility of employing a boys‐only screening algorithm that identifies males with ALD without identifying untreatable conditions. This approach will be of interest to countries that are considering ALD newborn screening but are reluctant to identify girls with ALD because for girls there is no direct health benefit. We also analyzed whether gestational age, sex, birth weight and age at heel prick blood sampling affect C26:0‐LPC concentrations and demonstrate that these covariates have a minimal effect.
A systematic review and clinical atlas on mucocutaneous presentations of the current monkeypox outbreak: With a comprehensive approach to all dermatologic and nondermatologic aspects of the new and previous monkeypox outbreaks
Authors: Pourriyahi Homa , Aryanian Zeinab , Afshar Zeinab Mohseni , Goodarzi Azadeh 
Published: October 2022

AbstractMonkeypox is a zoonotic disease, endemic in central and west African regions, and has re‐emerged, currently causing an outbreak as of May 2022. In this systematic review, we aimed to characterize the current face of the disease, with a detailed categorization of mucocutaneous, as well as systemic symptoms of the disease. We searched four main online databases with the keywords “monkeypox” and “Orthopoxvirus”. A total of 46 articles were included, with a cumulative number of 1984 confirmed cases. Patients were predominantly men who have sex with men, who were mostly in their 30s, with a history of unprotected sexual contact or international travel. Among mucocutaneous manifestations, anogenital lesions were the most commonly observed, followed by lesions on the limbs, face, trunk, and palms or soles. Among lesion types, vesiculopustular, pustular or pseudo‐pustular, vesicular‐umbilicated and papular lesions were the most common, mainly presenting asynchronously, with less than 10 lesions on each patient. Almost all patients also reported systemic manifestations, namely fever, lymphadenopathy, fatigue, myalgia, headaches, pharyngitis, and proctitis. Sexual contact is the main pathway of transmission in the current outbreak, with viral shedding in bodily fluids playing a key role. We've compared these idiosyncratic findings of the new outbreak with previous outbreaks. We've also gathered and categorized images from our included studies to make a “clinical atlas” for this “new” face of monkeypox, which can be of utmost importance for clinicians to be familiarized with, and have a clear picture of monkeypox for their differential diagnoses.
Estimation of monkeypox spread in a nonendemic country considering contact tracing and self‐reporting: A stochastic modeling study
Authors: Ko Youngsuk , Mendoza Victoria May , Mendoza Renier , Seo Yubin , Lee Jacob , Jung Eunok 
Published: October 2022

AbstractIn May 2022, monkeypox started to spread in nonendemic countries. To investigate contact tracing and self‐reporting of the primary case in the local community, a stochastic model is developed. An algorithm based on Gillespie's stochastic chemical kinetics is used to quantify the number of infections, contacts, and duration from the arrival of the primary case to the detection of the index case (or until there are no more local infections). Different scenarios were set considering the delay in contact tracing and behavior of infectors. We found that the self‐reporting behavior of a primary case is the most significant factor affecting outbreak size and duration. Scenarios with a self‐reporting primary case have an 86% reduction in infections (average: 5–7, in a population of 10 000) and contacts (average: 27–72) compared with scenarios with a non‐self‐reporting primary case (average number of infections and contacts: 27–72 and 197–537, respectively). Doubling the number of close contacts per day is less impactful compared with the self‐reporting behavior of the primary case as it could only increase the number of infections by 45%. Our study emphasizes the importance of the prompt detection of the primary case.