bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mushroom intake and cognitive performance among US older adults: the National Health and Nutrition Examination Survey, 2011–2014
Authors: Ba Djibril M. , Gao Xiang , Al-Shaar Laila , Muscat Joshua , Chinchilli Vernon M. , Ssentongo Paddy , Beelman Robert B. , Richie John 
Published: February 2022

AbstractEmerging evidence has suggested that mushrooms, which are a rich source of the potent antioxidants ergothioneine and glutathione as well as vitamin D, may have neuroprotective properties. This study investigated the association between mushroom consumption and cognitive performance in a nationally representative sample of US older adults. We analysed data from older adults aged ≥ 60 years from the 2011–2014 National Health and Nutrition Examination Survey. Mushroom intake was measured using up to two 24-h dietary recalls and was categorised into three groups (lowest, middle and highest). Cognitive function tests included the Animal Fluency (AF) Test; Consortium to Establish a Registry for Alzheimer’s Disease Delayed Recall (CERAD-DR) and Word Learning (CERAD-WL); and Digit Symbol Substitution Test (DSST). Multivariable linear regression models were developed, adjusting for socio-demographics, major lifestyle factors, self-reported chronic diseases and dietary factors, including the Healthy Eating Index-2015 score and total energy. The study included 2840 participants. Compared with the lowest category of mushroom intake, participants in the highest category (median intake = 13·4 g /4184 KJ (1000 kcal)/d) had higher scores for DSST (β = 3·87; 95 % CI 0·30, 7·45; P for trend = 0·03) and CERAD-WL (β = 1·05; 95 % CI 0·0003, 2·10; P for trend = 0·04). Similar non-significant trends were observed for AF (β = 0·24; 95 % CI −2·26, 2·73; P for trend = 0·92) but not for the CERAD-DR. Greater mushroom intake was associated with certain cognitive performance tests, suggesting regular mushroom consumption may reduce the risk of cognitive decline.
Analysis of consumer comments into PBAC decision-making (2014–9)
Authors: Tjeuw Emily , Wonder Michael J. 
Published: February 2022

Abstract

Objectives
The Pharmaceutical Benefits Advisory Committee (PBAC) is an independent expert body that recommends new technologies for listing on the Pharmaceutical Benefits Scheme. Its decision-making process is evidence-based and considers a technology's clinical effectiveness, safety, and cost-effectiveness compared with other technologies. Since 2014, the PBAC has formally taken into account input from those impacted by the technology via an online consumer comments portal and has also reported on received comments in the Public Summary Documents (PSDs). Comments are welcomed from those whose health the technology is trying to improve, as well as carers, clinicians, and organizations. Our objective was to analyze and review consumer comments in the PBAC's decision-making process.

Methods
We extracted information about consumer comments from the PBAC PSDs from 2014–9. We conducted simple descriptive analyses.

Results
Our findings reveal that two thirds of all submissions did not receive a single consumer comment. Of the remaining third, eight submissions (less than 1 percent) had a substantial number of consumer comments (>500). For these technologies, multiple submissions were required before a recommendation was issued. Submissions spanned multiple therapeutic areas, the therapeutic areas with the most consumer comments were genetic disease, pediatrics, and oncology.

Conclusions
In the light of our review, we have identified limitations to the current consumer comments process, and after an examination of the processes of other comparable health technology assessment agencies, we have identified a number of improvements that could be made to the PBAC's process to increase consumer engagement.
Towards improving coherence and diversity of slogan generation
Authors: Jin Yiping , Bhatia Akshay , Wanvarie Dittaya , Le Phu T. V. 
Published: February 2022

AbstractPreviouswork in slogan generation focused on utilising slogan skeletons mined from existing slogans. While some generated slogans can be catchy, they are often not coherent with the company’s focus or style across their marketing communications because the skeletons are mined from other companies’ slogans. We propose a sequence-to-sequence (seq2seq) Transformer model to generate slogans from a brief company description. A naïve seq2seq model fine-tuned for slogan generation is prone to introducing false information. We use company name delexicalisation and entity masking to alleviate this problem and improve the generated slogans’ quality and truthfulness. Furthermore, we apply conditional training based on the first words’ part-of-speech tag to generate syntactically diverse slogans. Our best model achieved a ROUGE-1/-2/-L
$\mathrm{F}_1$
score of 35.58/18.47/33.32. Besides, automatic and human evaluations indicate that our method generates significantly more factual, diverse and catchy slogans than strong long short-term memory and Transformer seq2seq baselines.
Surface and Intermediate Water Changes Triggering the Future Collapse of Deep Water Formation in the North Western Mediterranean
Authors: Parras‐Berrocal Iván M. , Vázquez Rubén , Cabos William , Sein Dimitry V. , Álvarez Oscar , Bruno Miguel , Izquierdo Alfredo 
Published: February 2022

AbstractDeep water formation (DWF) in the North Western Mediterranean (NWMed) is a key feature of Mediterranean overturning circulation. DWF changes under global warming may have an impact on the Mediterranean biogeochemistry and marine ecosystem. Here we analyze the deep convection in the Gulf of Lions (GoL) in a changing climate using a regional climate system model with a horizontal resolution high enough to represent DWF. We find that under the RCP8.5 scenario the NWMed DWF collapses by 2040–2050, leading to a 92% shoaling in the winter mixed layer by the end of the century. The collapse is related to a strengthening of the vertical stratification in the GoL caused by changes in properties of Modified Atlantic Water and Levantine Intermediate Water, being their relative contribution to the increase of the stratification 57.8% and 42.2%, respectively. The stratification changes also alter the Mediterranean overturning circulation and the exchange with the Atlantic.
Thirty Years of GOSHIP and WOCE Data: Atlantic Overturning of Mass, Heat, and Freshwater Transport
Authors: Caínzos V. , Hernández‐Guerra A. , McCarthy G. D. , McDonagh E. L. , Cubas Armas M. , Pérez‐Hernández M. D. 
Published: February 2022

AbstractThe Atlantic Meridional Overturning Circulation (AMOC) plays a vital role in global climate, redistributing heat, and freshwater. It is predicted to decline due to anthropogenic climate change, with major implications for global climate. Accurately assessing AMOC strength with in situ observations has inspired a number of dedicated observing systems in the Atlantic since the 2000s. However, no consensus has been reached on whether the slowdown of the AMOC and its associated heat and freshwater transports is occurring. These dedicated systems are too recent to detect long‐term trends. We have analyzed hydrographic data from zonal sections across the Atlantic for 30 years that predate and overlap the era of AMOC observations. Our results show no changes in the AMOC for all sections analyzed over the whole Atlantic for the last 30 years. We also find an increased export of freshwater from the South Atlantic associated with an increase in upper salinity.
Source‐To‐Sink Aeolian Fluxes From Arid Landscape Dynamics in the Lut Desert
Authors: Chanteloube Colin , Barrier Laurie , Derakhshani Reza , Gadal Cyril , Braucher Régis , Payet Vincent , Léanni Laëtitia , Narteau Clément 
Published: February 2022

AbstractWe analyze major landforms of the Lut Desert in Iran to provide a comprehensive source‐to‐sink picture of aeolian systems on time scales from decades to millions of years. We map the modern sandflows, along which we evaluate the volume and chronology associated with the excavation of mega‐yardangs upwind and the formation of giant dunes downwind. Sediment discharges deduced from long‐term erosion and deposition are of the same order of magnitude (105–106 m3 yr−1) as short‐term and medium‐term sand discharges derived from wind data and dune morphodynamics. At the scale of the internal aeolian sediment‐routing system of the Lut, we establish an overall sediment budget constrained by the joint development of the erosional and depositional landforms. Our findings thus quantify the geomorphic controls of aeolian processes on arid landscapes at multiple length and time scales, while providing information on mass exchanges between continents and atmosphere.
The Interannual Variability of Eddy Kinetic Energy in the Kuroshio Large Meander Region and Its Relationship to the Kuroshio Latitudinal Position at 140°E
Authors: Wang Qiang , Tang Youmin 
Published: February 2022

AbstractIn this study, the variability of eddy kinetic energy (EKE) in the Kuroshio large meander (LM) region is investigated using both satellite sea surface height observation and high‐resolution ocean reanalysis data. The results show that the EKE has a remarkable interannual variability and it is negatively leading correlated with the change in the Kuroshio latitudinal position at 140°E. The mechanism analysis suggests that the baroclinic instability and advection processes are responsible for the EKE interannual variability and its effect on the Kuroshio latitudinal position at 140°E. Specifically, before the high EKE level occurs, a cyclonic eddy generates at the east of Kii Peninsula in the background field. The rapid development of this eddy and its eastward movement to the LM region induce the isopycnal inclinations there and the associated horizontal density gradient, which leads to the strong baroclinic instability and promotes the evolution of the eddy field and the formation of the high EKE level. The developed strong eddies, especially the cyclonic eddies, move downstream to 140°E, which pushes the Kuroshio off the shore and causes the southerly Kuroshio latitudinal position at 140°E. On the contrary, when the cyclonic eddies do not appear in the LM region, the isopycnals are relatively flat, which is not conducive to the generation of baroclinic instability. Consequently, the EKE level is low and only weak eddies are advected to 140°E, which does not substantially shift the Kuroshio southward and thus results in the northerly Kuroshio position.
Observations Indicate That Clouds Amplify Mechanisms of Southern Ocean Heat Uptake
Authors: Morrison Ariel L. , Singh Hansi A. , Rasch Philip J. 
Published: February 2022

AbstractThe Southern Ocean has absorbed most of the excess heat associated with anthropogenic greenhouse gas emissions. Since Southern Ocean observations are sparse in certain regions and seasons, much of our knowledge of ocean heat uptake is based on climate model simulations. However, climate models still inadequately represent some properties of Southern Ocean clouds, and they have not identified the mechanisms by which clouds may affect Southern Ocean heat uptake (SOHU). Here, we use the ERA5 and JRA‐55 reanalyses to assess the influence of clouds and other atmospheric processes on SOHU from 1979 to 2020. We find that years with the highest SOHU between 45° and 65°S are dominated by ocean heat uptake anomalies during winter and spring, but not during summer or fall. Winter and spring cloud cover are up to 7% higher when SOHU is up to 5.5 W/m2 higher than the climatological seasonal mean, with the largest increases in the South Pacific Ocean. Clouds also contain more liquid water. These changes in cloud properties increase downwelling longwave radiation, amplifying ocean heat uptake. Cloud changes are also concomitant with a more stable lower atmosphere, which suppresses turbulent heat fluxes out of the surface. Overall, we find that SOHU is likely not mediated by enhanced surface shortwave absorption over the observational time period. A better understanding of how atmospheric processes impact ocean heat uptake may help improve our understanding of ocean heat uptake mechanisms in the current generation of climate models.
Effects of Aerosol–Induced Snow Albedo Feedback on the Seasonal Snowmelt Over the Himalayan Region
Authors: Usha K. H. , Nair Vijayakumar S. , Babu S. Suresh 
Published: February 2022

AbstractAerosol‐induced snow darkening and its feedback on seasonal snow cover, snowmelt, and runoff were investigated using the Regional Climate Model (RegCM4.6) coupled with SNow, Ice, and Aerosol Radiation (SNICAR) and aerosol modules over the Himalayas during the melting season (March‐September). The snow albedo reduction due to the deposition of absorbing aerosols increases the 2 m air temperature (1.47°C) and thus decreases the snow cover (10.6%) over the Himalayas during spring. This aerosol‐induced excess warming accelerates the seasonal snowmelt (1.2 mm day−1), which reduces the number of snow‐covered periods by more than 20 days throughout the Himalayas. The accumulated total snowmelt also increased by 41.3% over the Himalayas during the melting season. The early snowmelt and increase in runoff due to aerosol forcing have significant implications on rivers originating from the western Himalayas (Indus Basin). The change in snowmelt distribution and doubling of snowmelt extremes due to aerosol‐induced snow darkening could also translate to an increase in flood risks across the Himalayan river basins. Therefore, the present study highlights the importance of aerosol‐induced snow albedo forcing and its feedback on snowmelt and runoff over the Himalayan region, which has further implications on water availability over the South Asian region.
Spontaneous and TMS-related EEG changes as new biomarkers to measure anti-epileptic drug effects
Authors: Biondi Andrea , Rocchi L. , Santoro V. , Rossini P. G. , Beatch G. N. , Richardson M. P. , Premoli I. 
Published: February 2022

AbstractRobust biomarkers for anti-epileptic drugs (AEDs) activity in the human brain are essential to increase the probability of successful drug development. The frequency analysis of electroencephalographic (EEG) activity, either spontaneous or evoked by transcranial magnetic stimulation (TMS-EEG) can provide cortical readouts for AEDs. However, a systematic evaluation of the effect of AEDs on spontaneous oscillations and TMS-related spectral perturbation (TRSP) has not yet been provided. We studied the effects of Lamotrigine, Levetiracetam, and of a novel potassium channel opener (XEN1101) in two groups of healthy volunteers. Levetiracetam suppressed TRSP theta, alpha and beta power, whereas Lamotrigine decreased delta and theta but increased the alpha power. Finally, XEN1101 decreased TRSP delta, theta, alpha and beta power. Resting-state EEG showed a decrease of theta band power after Lamotrigine intake. Levetiracetam increased theta, beta and gamma power, while XEN1101 produced an increase of delta, theta, beta and gamma power. Spontaneous and TMS-related cortical oscillations represent a powerful tool to characterize the effect of AEDs on in vivo brain activity. Spectral fingerprints of specific AEDs should be further investigated to provide robust and objective biomarkers of biological effect in human clinical trials.
A systematic review and meta-analysis on the prevalence of non-malignant, organic gastrointestinal disorders misdiagnosed as irritable bowel syndrome
Authors: Poon Dennis , Law Graham R. , Major Giles , Andreyev H. Jervoise N. 
Published: February 2022

AbstractTreatable gastrointestinal disorders in patients with symptoms typical for irritable bowel syndrome (IBS) may be overlooked. The prevalence of five gastrointestinal conditions—bile acid diarrhoea (BAD), carbohydrate malabsorption (CM), microscopic colitis (MC), pancreatic exocrine insufficiency (PEI) and small intestinal bacterial overgrowth (SIBO) was systematically assessed from studies including consecutive patients meeting diagnostic criteria for IBS. 4 databases were searched from 1978 to 2020. Studies were included if they evaluated the prevalence of these conditions in secondary healthcare setting. Estimated pooled rates were calculated and statistical heterogeneity between studies was evaluated using Q and I2 statistics. Seven studies (n = 597) estimated the pooled prevalence for BAD as 41% (95% CI 29–54). 17 studies (n = 5068) estimated that of MC as 3% (95% CI 2–4%). Two studies (n = 478) suggested a rate of 4.6% (range: 1.8–6.1%) for PEI. Using breath testing, 26 studies (n = 6700) and 13 studies (n = 3415) estimated the prevalence of lactose and fructose malabsorption as 54% (95% CI 44–64%) and 43% (95% CI 23–62%); 36 studies (n = 4630) and 22 studies (n = 2149) estimated that of SIBO as 49% (95% CI 40–57%) with lactulose and 19% (95% CI 13–27%) with glucose. Rates of all conditions were significantly higher than in healthy controls. A significant proportion of patients presenting to secondary care with IBS have an organic condition which may account for their symptoms. Failure to exclude such conditions will deny patients effective treatment.
Dual detection high-speed capillary electrophoresis for simultaneous serum protein analysis and immunoassays
Authors: Opallage Prabhavie M. , De Silva Miyuru , Dunn Robert C. 
Published: February 2022

AbstractSerum protein electrophoresis (SPE) separates serum proteins into bands whose shape and amplitude can alert clinicians to a range of disorders. This is followed by more specific immunoassays to quantify important antigens and confirm a diagnosis. Here we develop a high-speed capillary electrophoresis (HSCE) platform capable of simultaneous SPE and immunoassay measurements. A single laser excitation source is focused into the detection zone of the capillary to measure both refractive index (SPE) and fluorescence signals (immunoassays). The refractive index signal measures characteristic SPE profiles for human serum separated in 100 mM boric acid (pH 10), 100 mM arginine (pH 11), and 20 mM CHES (pH 10). For the immunoassay, the fluorescence electropherograms reveal that CHES provides the optimal buffer for measuring the immunocomplex and separating it from the free antigen. Immunoassays in CHES yield a LOD of 23 nM and a LOQ of 70 nM for the detection of fluorescein. The high pH reduces protein adsorption but reduces antibody affinity. Preliminary studies carried out in 50 mM barbital at pH 8 show improved stability of the immunocomplex and better separation for immunoassay quantification. Further optimization will open new capabilities for measuring orthogonal diagnostic signals in seconds with HSCE.
Treatment outcomes of Mycobacterium avium complex pulmonary disease according to disease severity
Authors: Kim Bo-Guen , Jhun Byung Woo , Kim Hojoong , Kwon O Jung 
Published: February 2022

AbstractMycobacterium avium complex pulmonary disease (MAC-PD) requires long-term treatment. We analyzed the outcomes of 992 MAC-PD patients according to disease severity and compared the outcomes of intermittent and daily therapy for mild disease. Patients were divided into groups according to severity using the body mass index, age, cavity, erythrocyte sedimentation rate, and sex (BACES) system, and culture conversion rates were evaluated. We also evaluated the effects of intermittent treatment on the culture conversion rates in mild disease group. Using the BACES, 992 patients were divided into mild (n = 331), moderate (n = 503), and severe (n = 158) disease groups, and culture conversion at the end of treatment was achieved in 85% (282/331), 80% (403/503), and 61% (97/158), respectively. Differences in culture conversion among the severity groups were significant (p < 0.001). In patients with mild disease, culture conversion rates were similar between intermittent (84%, 166/198) and daily (87%, 116/133) treatment (p = 0.396), and intermittent antibiotic therapy did not negatively impact culture conversion (adjusted hazard ratio 1.08; confidence interval 0.83–1.41; p = 0.578). MAC-PD patients with mild disease had higher culture conversion rates. Daily and intermittent therapy yielded similar culture conversion rates for mild disease. Treatment strategies with lower pill burden may be applicable in mild MAC-PD.
Can the one-zone hadronuclear model explain the hard-TeV spectrum of BL Lac objects?
Authors: Li Wei-Jian , Xue Rui , Long Guang-Bo , Wang Ze-Rui , Nagataki Shigehiro , Yan Da-Hai , Wang Jian-Cheng 
Published: February 2022

Context. The intrinsic TeV emission of some BL Lacs is characterized by a hard spectrum (the hard-TeV spectrum) after correcting for the extragalactic background light. The hard-TeV spectra pose a challenge to conventional one-zone models, including the leptonic model, the photohadronic model, the proton synchrotron model, and others.
Aims. In this work, we aim to investigate whether or not the one-zone hadronuclear (pp) model can be used to interpret the hard-TeV spectra of BL Lacs without introducing extreme parameters.
Methods. We provide analytical calculations that can be used to study whether or not there is a parameter space, and whether or not the charge neutrality condition of the jet can be satisfied when interpreting the hard-TeV spectra of BL Lacs without introducing a super-Eddington jet power.
Results. We find that in a sample of hard-TeV BL Lacs previously collected, only the hard-TeV spectrum of 1ES 0229+200 can be explained by γ-rays from π0 decay produced in the pp interactions, but at the cost of setting a small radius of the radiation region than the Schwarzschild radius of the central black hole. Combining our findings with those of previous studies of other one-zone models, we suggest that the hard-TeV spectra of BL Lacs cannot be explained by a one-zone model without introducing extreme parameters, and should originate from the multiple radiation regions.
Gastrointestinale Blutungen bei Patienten mit linksventrikulärem Assist Device
Authors: Andersen Nils 
Published: February 2022

ZusammenfassungAufgrund der stetig wachsenden Anzahl von Patienten mit fortgeschrittener und terminaler Herzinsuffizienz und der begrenzten Verfügbarkeit von Spenderorganen nimmt die breite Verwendung von LVADs bei diesem Krankheitsbild zu. In den letzten 30 Jahren hat sich die mechanische Kreislaufunterstützung von einer experimentellen Therapieform zu einer effizienten und anerkannten Behandlung der chronischen Herzinsuffizienz entwickelt. Die neueren Systeme führten zu einer Senkung der Komplikationsraten bei zunehmender Überlebenswahrscheinlichkeit, klinischer Leistung und erhöhter Lebensqualität. Trotzdem bleibt die gastrointestinale Blutung eine der häufigsten Komplikationen bei dieser Therapieform. Dies ist durch mehrere Studien gut belegt.
Umbilical Cord Teratoma Presenting as Ruptured Omphalocele
Authors: Doktor Fabian , Gosemann Jan-Hendrik , Zimmermann Peter , Siekmeyer Manuela , Stepan Holger , Lacher Martin 
Published: February 2022

AbstractCongenital mature teratomas of the umbilical cord are extremely rare. We report on a girl who presented with a ruptured omphalocele and a 7 cm mass connected to the umbilicus, which we resected on the first day of life. Histology revealed mature umbilical cord teratoma . On the 29th day of life, a secondary laparotomy was necessary to address the associated intestinal malformations (megaduodenum, stenotic small bowel with duplication and malrotation). After a prolonged hospital stay, we discharged the patient in age-appropriate conditions. Antenatal diagnosis of an umbilical cord tumor can be challenging in the presence of an omphalocele. Given the high prevalence of associated malformations, the finding of umbilical cord teratoma should be followed by a detailed and comprehensive neonatal workup for additional abnormalities.