bluuebunny/crossref_metadata_2025_split huggingface dataset:
CEA-Ki-67- Pathologic Subtype: An Adjunct Factor for Refining Prognosis in Stage I Pulmonary Adenocarcinoma
Authors: Yu Dongzhi , Sun Yanbin , McNutt Michael A. , Xu Shun 
Published: April 2022

ObjectivesThe prognosis for stage I pulmonary adenocarcinoma is generally good. However, some patients with stage I pulmonary adenocarcinoma have an unexpectedly poor outcome. This warrants consideration of adjunct markers. In this study, we analyze carcinoembryonic antigen, Ki-67, and a pathologic subtype in combination for prognostic evaluation of stage I pulmonary adenocarcinoma. These factors were selected for study as they have been shown to be individually associated with prognosis in many studies.MethodsA total of 650 patients with stage I pulmonary adenocarcinoma were investigated retrospectively. Each patient was re-staged using standard TNM criteria. Carcinoembryonic antigen (CEA) values were obtained from preoperative blood samples, and Ki-67 was evaluated with tumor tissue immunohistochemistry. Patient clinicopathologic characteristics, survival status, and date of death were obtained from medical records and telephone follow-up.ResultsCEA &gt; 4.4 ng/ml, Ki-67 &gt; 13%, and a solid-micropapillary tumor growth pattern were each independent adverse prognostic markers for 5-year disease specific survival in stage I pulmonary adenocarcinoma. However, in combination, these 3 factors yielded a prognostic value (designated “CEA-Ki-67-pathologic subtype” value). Stage I pulmonary adenocarcinoma of low-risk CEA-Ki-67-pathologic subtype (CKP) value show biologic behavior similar to TNM stage IA1 tumors, while stage I tumors of high-risk CKP value are similar in prognosis to TNM stage II.ConclusionThe CKP value may be used as an adjunct to the TNM classification, which may yield a more accurately defined prognosis for cases of stage I pulmonary adenocarcinoma. CKP value may identify patients at higher risk who may benefit from adjuvant chemotherapy. Conversely, lower risk CKP values may support avoidance of chemotherapy.
Reduced Preoperative Glomerular Filtration Rate Is Associated With Adverse Postoperative Oncological Prognosis in Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Retrospective Cohort Study
Authors: Li Shijie , Chen Xiaonan , Zheng Jianyi , Liu Xuefeng 
Published: April 2022

ObjectiveTo evaluate the association between perioperative estimated glomerular filtration rate (eGFR) and postoperative oncological outcomes in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU),and to evaluate the effect of sex on this association.MethodsThe medical records of patients with UTUC who underwent RNU between January 2012 and December 2017 at our hospital were retrospectively reviewed. Patients were divided into three groups based on preoperative eGFRs: normal eGFR (&gt;60 mL/min/1.73 m2; n = 179), moderately reduced eGFR (45–60 mL/min/1.73 m2; n = 45), and severely reduced eGFR (≤ 45 mL/min/1.73 m2; n = 36). Statistical analyses were performed to evaluate the prognostic impact of preoperative eGFR on prognosis.ResultsPatient mean age was 66.7 ± 9.6 years, and 47.9% were female. Multivariate regression analysis based on Cox proportional risk models and Kaplan-Meier survival rates showed that lower preoperative eGFR was associated with decreased OS, PFS, and CSS. In the adjusted Cox regression model, patients with normal and moderately reduced eGFRs had a decreased hazard for mortality, with adjusted hazard ratios of 0.13 [95% confidence interval (CI): 0.07–0.26] and 0.36 (95% CI: 0.18–0.73), respectively (P &lt; 0.001). The smooth fitting curve suggested a linear relationship between eGFR and prognostic survival. Additionally, sensitivity subgroup analyses verified an inverse relationship between the reduced eGFR and OS. Women had a lower eGFR and worse oncological outcomes than men. A nomogram for OS was developed based on multivariate analysis with a C-index of 0.754 (95% CI: 0.728–0.779).ConclusionPreoperative renal insufficiency is strongly associated with a higher risk of cancer progression and a lower survival probability. It is important to identify preoperative renal insufficiency in patients with UTUC, particularly female patients.
A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells
Authors: Blake Bevin E. , Rickard Brittany P. , Fenton Suzanne E. 
Published: April 2022

Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous environmental contaminants that have been associated with adverse pregnancy outcomes in women and experimental research models. Adverse developmental and reproductive outcomes have been investigated for relatively few PFAS, and such studies are not scalable to address the thousands of unique chemical structures. As the placenta has been reported as a PFAS target tissue, the human placental trophoblast JEG-3 cell line was employed in a high-throughput toxicity screen (HTTS) to evaluate the effects of 42 unique PFAS on viability, proliferation, and mitochondrial membrane potential (MMP). HTTS concentration-response curve fitting determined EC50 values for 79% of tested compounds for at least one of the three endpoints. Trophoblast migratory potential was evaluated for a subset of six prioritized PFAS using a scratch wound assay. Migration, measured as the percent of wound closure after 72 h, was most severely inhibited by exposure to 100 µM perfluorooctanoic acid (PFOA; 72% closure), perfluorooctanesulfonic acid (PFOS; 57% closure), or ammonium perfluoro-2-methyl-3-oxahexanoate (GenX; 79% closure). PFOA and GenX were subsequently evaluated for disrupted expression of 46 genes reported to be vital to trophoblast health. Disrupted regulation of oxidative stress was suggested by altered expression of GPEX1 (300 µM GenX and 3 µM GenX), GPER1 (300 µM GenX), and SOD1 and altered cellular response to xenobiotic stress was indicated by upregulation of the placental efflux transporter, ABCG2 (300 µM GenX, 3 µM GenX, and 100 µM PFOA). These findings suggest the placenta is potentially a direct target of PFAS exposure and indicate that trophoblast cell gene expression and function are disrupted at PFAS levels well below the calculated cytotoxicity threshold (EC50). Future work is needed to determine the mechanism(s) of action of PFAS towards placental trophoblasts.
A Scalable Digit-Parallel Polynomial Multiplier Architecture for NIST-Standardized Binary Elliptic Curves
Authors: Kumar Harish , Rashid Muhammad , Alhomoud Ahmed , Khan Sikandar Zulqarnain , Bahkali Ismail , Alotaibi Saud S. 
Published: April 2022

This work presents a scalable digit-parallel finite field polynomial multiplier architecture with a digit size of 32 bits for NIST-standardized binary elliptic fields. First, a dedicated digit-parallel architecture is proposed for each binary field recommended by NIST, i.e., 163, 233, 283, 409 and 571. Then, a scalable architecture having support for all variants of binary fields of elliptic curves is proposed. For performance investigation, we have compared dedicated multiplier architectures with scalable design. After this, the dedicated and scalable architectures are compared with the most relevant state-of-the-art multipliers. All multiplier architectures are implemented in Verilog HDL using the Vivado IDE tool. The implementation results are reported on a 28 nm Virtex-7 FPGA technology. The dedicated multipliers utilize slices of 1182 (for m=163), 1451 (for m=233), 1589 (for m=283), 2093 (for m=409) and 3451 (for m=571). Moreover, our dedicated designs can operate at a maximum frequency of 500, 476, 465, 451 and 443 MHz. Similarly, for all supported binary fields, our scalable architecture (i) utilizes 3753 slices, (ii) achieves 305 MHz clock frequency, (iii) takes 0.013 μs for one finite field multiplication and (iv) consumes 3.905 W power. The proposed scalable digit-parallel architecture is more area-efficient than most recent state-of-the-art multipliers. Consequently, the reported results and comparison to the state of the art reveal that the proposed architectures are well suited for cryptographic applications.
Integrative Analysis of Expression Profiles of mRNA and MicroRNA Provides Insights of Cotton Response to Verticillium dahliae
Authors: Mei Jun , Wu Yuqing , Niu Qingqing , Miao Meng , Zhang Diandian , Zhao Yanyan , Cai Fangfang , Yu Dongliang , Ke Liping , Feng Hongjie , Sun Yuqiang 
Published: April 2022

Cotton Verticillium wilt, caused by the notorious fungal phytopathogen Verticillium dahliae (V. dahliae), is a destructive soil-borne vascular disease and severely decreases cotton yield and quality worldwide. Transcriptional and post-transcriptional regulation of genes responsive to V. dahliae are crucial for V. dahliae tolerance in plants. However, the specific microRNAs (miRNAs) and the miRNA/target gene crosstalk involved in cotton resistance to Verticillium wilt remain largely limited. To investigate the roles of regulatory RNAs under V. dahliae induction in upland cotton, mRNA and small RNA libraries were constructed from mocked and infected roots of two upland cotton cultivars with the V. dahliae-sensitive cultivar Jimian 11 (J11) and the V. dahliae-tolerant cultivar Zhongzhimian 2 (Z2). A comparative transcriptome analysis revealed 8330 transcripts were differentially expressed under V. dahliae stress and associated with several specific biological processes. Moreover, small RNA sequencing identified a total of 383 miRNAs, including 330 unique conserved miRNAs and 53 novel miRNAs. Analysis of the regulatory network involved in the response to V. dahliae stress revealed 31 differentially expressed miRNA–mRNA pairs, and the up-regulation of GhmiR395 and down-regulation of GhmiR165 were possibly involved in the response to V. dahliae by regulating sulfur assimilation through the GhmiR395-APS1/3 module and the establishment of the vascular pattern and secondary cell wall formation through GhmiR165-REV module, respectively. The integrative analysis of mRNA and miRNA expression profiles from upland cotton lays the foundation for further investigation of regulatory mechanisms of resistance to Verticillium wilt in cotton and other crops.
RESTRUKTURISASI KREDIT DALAM PELAKSANAAN KEBIJAKAN COUNTERCYCLICAL DAMPAK PENYEBARAN COVID-19 DI PT. BPRS BAITURRAHMAN
Authors: Maulina Rina , Mulyadi Roni 
Published: April 2022

Abstrak: Penulisan ini dilakukan bertujuan untuk mengetahui bagaimana prosedur restrukturisasi atau relaksasi kredit kepada peminjam/debitur yang usahanya terdampak covid-19, yang tertuang dalam Peraturan OJK (POJK) nomor 11/POJK.03/2020 tentang Stimulus Perekonomian Nasional sebagai Kebijakan Countercyclical Dampak Penyebaran Coronavirus Disease 2019 pada PT. BPRS Baiturrahman. Pengumpulan data dan informasi melalui studi empiris karena melakukan observasi atau penelitian secara langsung ke lapangan guna mendapatkan kebenaran yang akurat dalam proses penyempurnaan penulisan jurnal. Restrukturisasi berdasarkan POJK nomor 29/POJK.03/2019 tentang Kualitas Aset Produktif dan Pembentukan Penyisihan Penghapusan Aset Produktif Bank Pembiayaan Rakyat Syariah adalah upaya yang dilakukan BPRS dalam kegiatan pembiayaan terhadap nasabah yang mengalami kesulitan untuk memenuhi kewajibannya, antara lain: (1) Penjadwalan kembali, (2) Persyaratan kembali, (3) Penataan kembali. Kata kunci: Restrukturisasi, Penerbitan POJK, Penerapan Kebijakan Countercyclical Abstract: The purpose of this writing is to find out how the procedure for restructuring or relaxing credit to borrowers / debtors whose business is impacted by co-19, which is contained in OJK Regulation (POJK) number 11 / POJK.03 / 2020 concerning National Economic Stimulus as a Countercyclical Policy on the Impact of Spreading Coronavirus Disease 2019 at PT. SRB Baiturrahman. Collecting data and information through empirical studies because of direct observation or research in the field in order to obtain accurate truths in the process of perfecting journal writing. Restructuring based on POJK number 29 / POJK.03 / 2019 concerning Quality of Earning Assets and Formation of Allowance for Earning Assets of Sharia Rural Banks is an effort made by the BPRS in financing activities for customers who have difficulty meeting their obligations, including: (1) Rescheduling , (2) Re-requirement, (3) Re-arrangement. Keywords: Restructuring, Issuance of POJK, Application of Countercyclical Policy
Estimation of effective reaction radius for catalytic chain reaction of chemically amplified resist by Bayesian optimization
Authors: Jin Yuqing , Kozawa Takahiro 
Published: April 2022

Abstract
The modeling of electron beam (EB) lithography processes from exposure to development is important for resist pattern prediction and material design. The effective reaction radius for deprotection indicates the capability of chemically amplified resists. However, this parameter cannot be directly measured by experiments. On the other hand, the concentration of protected units determines the resist pattern after development. To simulate the lithography processes, these two parameters must be estimated. In this study, we developed a strategy to determine these two parameters at the same time by Bayesian optimization to reduce the computational time. The simulation results were compared with the scanning electron microscopy images of resist patterns obtained by EB lithography. As a typical Bayesian inference method, Gaussian process regression with the Matérn kernel was applied to the analysis, which reduced the iterative calculation from 140 to 35. The probable effective reaction radius was found.
In-depth characterization of switching dynamics in amorphous HfO2 memristive arrays for the implementation of synaptic updating rules
Authors: Perez Eduardo , Mahadevaiah Mamathamba K. , Perez-Bosch Quesada Emilio , Wenger Christian 
Published: April 2022

Abstract
Accomplishing truly analog conductance modulation in memristive arrays is crucial in order to implement the synaptic plasticity in hardware-based neuromorphic systems. In this paper, such a feature was addressed by exploiting the inherent stochasticity of switching dynamics in amorphous HfO2 technology. A thorough statistical analysis of experimental characteristics measured in 4 kbit arrays by using trains of identical depression/potentiation pulses with different voltage amplitudes and pulse widths provided the key to develop two different updating rules and to define their optimal programming parameters. The first rule is based on applying a specific number of identical pulses until the conductance value achieves the desired level. The second one utilized only one single pulse with a particular amplitude to achieve the targeted conductance level. In addition, all the results provided by the statistical analysis performed may play an important role in understanding better the switching behavior of this particular technology.
Femtosecond Z-scan measurement of third-order nonlinear optical response of fluorine-doped tin oxide
Authors: Zhu Hao , Huang Jing , Li Jie , He Yuan , Chen Longlong , Hu Jianbang , Miao Lili , Xu Yanhua , Zhao Chujun 
Published: April 2022

Abstract
The excitation wavelength dependent nonlinear optical response of fluorine-doped tin oxide (FTO) is systematically studied by the Z-scan technique. The broadband third-order nonlinear optical properties of FTO are verified and a value of nonlinear refractive index coefficient n
2 to be 2.52 × 10−16 m2 W−1 is obtained at epsilon-near-zero region. Meanwhile, a large modulation depth and nonlinear absorption coefficient β are estimated about 9.61% and −1.96 × 10−9 m W−1, respectively. The experimental results indicate that FTO is a promising nonlinear optical material and has great application potential in the field of nonlinear optical devices.
Pengaruh Teknik Penilaian Terhadap Hasil Belajar Matematika Pada Materi Bilangan Bulat Ditinjau Dari Sikap Siswa
Authors: Asma Andi 
Published: April 2022

<p><em>Kompetensi guru menjadi isu penting dalam beberapa tahu terakhir, khususnya bagaimana kompetensi guru Ketika pandemi covid-19, dan yang menjadi perhatian utama adalah kemahiran guru dalam melakukan Teknik penilaian terhadap hasil belajar siswa di kelas. Penelitian</em><em> </em><em>bertujuan untuk melihat</em><em> pengaruh teknik penilaian terhadap hasil belajar</em><em> matematika pada materi b</em><em>ilangan bulat ditinjau dari sikap siswa. Penelitian ini dilakukan </em><em> pada SD/MI yang ada di kota makassar </em><em>dengan sampel </em><em>2</em><em>0 sis</em><em>wa</em><em> dengan</em><em> teknik</em><em> purposive sampling. </em><em>Data dikumpulkan dengan menggunakan</em><em> </em><em> kuesioner</em><em> dan </em><em>tes </em><em>hasil belajar</em><em>, analisis data menggunakan</em><em> </em><em>two way </em><em>AN</em><em>O</em><em>VA</em><em> </em><em>(</em><em>desain </em><em>faktorial</em><em> 2 x 2</em><em>)</em><em>. Adapun hasil dari penelitian ini adalah 1) hasil belajar matematika pada materi bilangan bulat pada siswa dengan </em><em>menerapkan </em><em>teknik penilaian kinerja lebih tinggi dibandingkan dengan siswa yang mendapat penilaian tes uraian, 2) dari sikap siswa terdapat interaksi antara teknik </em><em>penilaian dengan hasil belajar bilangan bulat</em><em>, 3)</em><em> pembelajaran matematika materi bilangan bulat pada kelompok siswa yang memiliki sikap positif </em><em>yang mendapat penilaian kinerja lebih tinggi daripada penilaian tes uraian. </em><em></em></p>
SEMIOTIC ANALYSIS IN INSTAGRAM LOGO
Authors: Payuk Eva Eriva Tandi , Zakrimal Zakrimal 
Published: April 2022

This article investigated about semiotic found in Instagram logo. This article used Instagram, because many people nowadays used Instagram to express themselves. Â The aim of this study is to find out the connotative and denotative meaning through Instagram. The writers used John theory to reveal this study. In this research, the writers applies the qualitative descriptive method. The method of collecting data is observation. The steps are choosing the logo that would be analyzed. The results indicate there are twelve data that have meaning from different logos on Instagram. They all have different functions based on the logo. The conclusion is Instagram as a social media application that allows users to share photos and videos, add captions, edit filters, engage with others, and explore the world by using this application.
THE INTELLECTUAL DISABILITY OF THE MAIN CHARACTER AND ITS EDUCATIONAL VALUES OF THE FORREST GUMP MOVIE
Authors: Astuti Windi , Prasetyo Hazairin Eko 
Published: April 2022

The present study aims to find out and describe the educational values reflected in the main character suffering from intellectual disability in Forrest Gump movie and to find out how the intellectual disability influenced the behaviour of the main character in Forrest gump movie. The writer used descriptive qualitative method. The data were in the form of words and sentences. This study was as a qualitative research in which the data were collected from primary and secondary sources. The primary source was the movie itself and its script. The secondary sources were articles, and several references on literature. After the data had been collected the writer used suitable scenes and conversations to analyze the types of educational values in the story. The results reveal that 1) The educational values reflected through the main character were bravery, peace, confidence and potential, loyalty and trustworthiness, respect, love and affection, unselfishness, kindness and friendliness, fairness and humanistic attitudeÂ 2) The intellectual disability affected the behavior of the main character including â€œdifficult to understand some thingsâ€, â€œless able to make decisionâ€, and â€œmake him unaware with some situationsâ€.
THE ROLE OF LEARNING STYLES IN STUDENTS’ ENGLISH ACADEMIC ACHIEVEMENT AT MTSN 2 TEMBILAHAN
Authors: Sauhana Felci Tria , Yeni Melda 
Published: April 2022

Abstract
The goals of this research are to identify the role of learning styles in the MTsN 2 Tembilahan academic achievement of students in English and also to know whether or not they have some learning styles to absorb and understand lessons. The results of data analysis obtained that visual learning style has no significant effect on students achievement because t test = 1.700 < t table = 1.97519 with a significance level of 0.091. While Audio learning style has an effect on students’ achievement because t test = 6.195 > t table = 1.97519 with a significance level of 0.000. Then, kinesthetic learning style has an effect on student achievement because t count = 3.009 > t table = 1.97519 with a significance level of 0.003 the learning styles. Besides, simultaneously or simultaneously all independent variables affect the independent variables. This is because f table 25.260 is greater than f table = 2.66 with a significance level of 0.000 less than 0.05. It can also be said that the Visual, Audio and Kinesthetic variables have a simultaneous effect on the Students’ English Achievement variable.
Keywords: Learning Style, Visual Learning Style, Auditory Learning Style, Kinesthetic Learning Style, Students Achievement
STRATEGIES AND PRAGMATIC EQUIVALENCE OF THE WORD FUCK TRANSLATION IN THE WOLF OF WALL STREET MOVIE
Authors: Ibnus Nizar 
Published: April 2022

The choice of strategy for translating the word fuck in The Wolf of Wall Street movie has its own impact on the equivalence of pragmatic meanings in the target text. This study aims to explain: (1) form, pragmatic function, and translation strategy of the word fuck, and (2) the implication of the word fuck translation strategy on pragmatic equivalence in The Wolf of Wall Street movie. The words of fuck were identified from the both English and Indonesian subtitles. Then, the data were categorized and the implications were investigated. The results indicate that there are 506 words of fuck which are classified into three forms, namely: interjection, emphasizer, and expletive slot filler. The functions conveyed by these taboo words are: catharsis, abusive, and social. These taboo words were translated using omission (72.9%), cultural substitution (15.0%), neutral words (11.5%) and loan word (0.6%). The omission and the neutral word strategy largely eliminated the function of the word fuck, whereas the loan word and cultural substitution strategy were able to maintain the function of the word fuck. However, the very large percentage of use of the omission strategy makes the translation results lose much of its pragmatic function and emotive value.
Keywords: Translation strategy, taboo word, pragmatic equivalence, the wolf of wall street movie