bluuebunny/crossref_metadata_2025_split huggingface dataset:
Budget impact analysis of HARMONIC FOCUS™+ Shears for mastectomy and breast-conserving surgery with axillary lymph node dissection compared with monopolar electrocautery from an Italian hospital perspective
Authors: Piemontese Alessandra , Galvain Thibaut , Swindells Lirazel , Parago Vito , Tommaselli Giovanni , Jamous Nadine 
Published: June 2022

Background
Mastectomy or breast conserving surgery, both with axillary lymph node dissection, are common treatments for early-stage breast cancer. Monopolar electrocautery is typically used for both procedures, despite evidence of improved clinical outcomes with HARMONIC FOCUS™+. This analysis evaluated the budget impact of adopting HARMONIC FOCUS™+ versus monopolar electrocautery for patients undergoing these procedures from an Italian hospital perspective.

Methods
Total costs for an annual caseload of 100 patients undergoing mastectomy or breast conserving surgery, with axillary lymph node dissection, with either the intervention or comparator were calculated. Italian clinical and cost input data were utilised. The analysis included costs for the device, operating room time, postoperative length of stay, treating seroma and managing postoperative chest wall drainage. Deterministic and probabilistic sensitivity analyses assessed uncertainty of model input values. Two scenario analyses investigated the impact of conservative estimates of postoperative length of stay reduction and daily hospital cost on the simulated cost difference.

Results
HARMONIC FOCUS™+ achieves annual savings of EUR 100,043 compared with monopolar electrocautery, derived from lower costs for operating room time, postoperative length of stay and seroma and postoperative chest wall drainage management, offsetting the incremental device cost increase (EUR 43,268). Cost savings are maintained in scenario analyses and across all variations in parameters in deterministic sensitivity analysis, with postoperative hospital stay costs being key drivers of budget impact. The mean (interquartile range) cost savings with HARMONIC FOCUS™+ versus monopolar electrocautery in probabilistic sensitivity analysis are EUR 101,637 (EUR 64,390–137,093) with a 98% probability of being cost saving.

Conclusions
The intervention demonstrates robust cost savings compared with monopolar electrocautery for mastectomy or breast conserving surgery, with axillary lymph node dissection, in an Italian hospital setting, and improved clinical and resource outcomes. These findings, with other clinical and cost analyses, support HARMONIC FOCUS™+ use in this setting.
I don’t know what type of arthritis I have: A population-based comparison of people with arthritis who knew their specific type and those who didn’t
Authors: Badley Elizabeth M. , Wilfong Jessica M. , Chan Christina H. , Canizares Mayilee , Perruccio Anthony V. 
Published: June 2022

ObjectiveTo understand differences between people with arthritis who do not know their type (DK) compared to those reporting osteoarthritis (OA) or inflammatory and autoimmune types of arthritis (IAA), including the receipt of appropriate health care, information, and services.MethodsAnalysis of the Survey on Living with Chronic Disease in Canada–Arthritis Component. Respondents aged ≥20 years with health professional-diagnosed arthritis (n = 4,385) were characterized as reporting DK, OA or IAA. Variables: arthritis characteristics (duration, number and site of joints affected), arthritis impact (current pain and fatigue, difficulty in sleeping and daily activities, impact on life), health (self-rated general and mental health, life stress), arthritis management strategies (seeing health professionals, medication use, assistive devices, receipt of arthritis information, self-management activities). Multinomial logistic and log-Poisson regressions were used, as appropriate, to compare the DK to the OA and IAA groups.ResultsIn this arthritis sample, 44.2% were in the DK group, 38.3% reported OA and 17.5% reported IAA. Those in the DK group were more likely to be younger, have low income, low education, and be of non-white cultural background compared to those with OA. There were no significant differences in arthritis impact, but the DK group was less likely to have received information on, or have used, arthritis management strategies.ConclusionsThe sociodemographic characteristics of the DK group suggest they likely have lower health literacy. They were less likely to have accessed health care and other support services, indicating this is an important group for health education, both for individuals with arthritis and health care providers.
One-year mortality of emergency department patients with substance-induced psychosis
Authors: Barbic David , Whyte Madelyn , Sidhu Gurwinder , Luongo Allesandra , Chakraborty Tapash Apu , Scheuermeyer Frank , Honer William G. , Stenstrom Robert 
Published: June 2022

Objectives
Psychosis is a well established complication of non-prescription drug use. We sought to measure the 1-year mortality of emergency department patients with substance-induced psychosis (SIP).

Methods
This study was a multi-centre, retrospective electronic medical records review of patients presenting to the ED with substance-induced psychosis (SIP). We interrogated the hospital ED database from Jan 1, 2018 and Jan 1, 2019 to identify consecutive patients. All patients were followed for one year from index visit, and classified as alive/dead at that time. Patients were included in the study if they met the following criteria: 1) ED discharge diagnosis of psychosis NOS and a positive urine drugs of abuse screen (UDAS) or the patient verbally endorsed drug use, or 2) Mental disorder due to drug use and “disorganized thought”, “bizarre behavior” or “delusional behavior” documented in the chart and one or more of the following criteria: a) arrival with police, b) mental health certification, c) physical restraints, d) chemical restraints. We excluded patients who were not British Columbia residents, since we were unable to ascertain if they were alive or dead at 1 year from their index ED visit. Primary statistical analysis was logistic regression for risk of death in 1 year, based on plausible risk factors, selected a priori.

Results
We identified 813 presentations for SIP (620 unique patients). The median age of the entire cohort was 35 years (IQR 28–44), and 69.5% (n = 565) were male. Thirty five patients (4.3%; 95% CI 3.2–5.9) had died one year after their initial presentation to the ED for SIP. Separate multivariable logistic regression analyses, controlling for age, demonstrated schizophrenia (OR 4.2, 95% CI 1.8–11.1) significantly associated with increased 1-year mortality.

Conclusions
In our study of patients presenting to the ED with SIP, the 1-year mortality was 4.3%. Controlling for age, schizophrenia was a notable risk factor for increased 1-year mortality.
The impact of non-motor disorders on the quality of life of patients with cervical muscular dystonia
Authors: Nodel M. R. , Salouhina N. I. , Tolmacheva V. A. 
Published: June 2022

Cervical dystonia (CD) has a wide range of non-motor (neuropsychiatric, sensory, dyssomnic) disorders. Relationships between dystonia, nonmotor manifestations of the disease and patients quality of life (QoL) require clarification.Objective: to clarify the impact of dystonia, sensory, affective, behavioral disorders, quality of sleep and wakefulness on the quality of life of patients with CD.Patients and methods. We examined 61 patients with CD (mean age – 48.03±11.49 years, mean duration of CD – 4.89±4.05 years). We used Toronto Western Hospital Spasmodic Torticollis Rating Scale (TWSTRS), Cervical Dystonia Quality of Life Questionnaire (CDQ-24, with five subscales: «stigma», «emotional wellbeing», «pain», «activities of daily living», «social/family life»), Spielberger–Khanin Inventory (STAI),Beck Depression Inventory (BDI), Barratt Behavioral Impulsivity (BIS-11), Yale–Brown Obsessive Compulsive Scale (Y-BOCS), Montreal Cognitive Assessment Scale (MoCA), Stroop Test (VST), 12 Word Memory Test, Pittsburgh Sleep Quality Assessment Scale (PSQI), Epworth Sleepiness Scale (ESS).Results and discussion. There was a deterioration in all characteristics of QoL in patients with CD, largely in emotional well-being, stigmatization, pain syndrome (50% change from the maximum CDQ-24 score). A statistically significant moderate correlation was established between the total assessment of QoL and the severity of dystonia (r=0.35; p<0.01), a statistically significant strong correlation between the total assessment of QoL and depression index (r=0.73; p<0.001 ), moderate strength correlation – with indicators of anxiety (r=0.65; p<0.01), obsessivecompulsive disorders (r=0.61; p<0.01), sleep quality (r=0.52; p<0.001), impulsiveness in behavior (r=0.31; p<0.01), weak relationship with the assessment of executive cognitive functions (according to the Stroop test interference index; r=0.24; p<0.01). A statistically significant moderate correlation was found between the assessments of activity in everyday, social/family life and impulsiveness in behavior (r=0.33; p<0.001); between stigma, emotional well-being and an indicator of executive cognitive functions (r=0.3; p<0.05). There were no statistically significant relationships between indicators of affective, cognitive functions, behavioral disorders and the severity of dystonia. There was a moderate correlation between pain score and dystonia severity (r=0.35; p<0.01).Conclusion. The decrease in QoL in patients with CD is largely due to affective, sensory, and behavioral disorders. Diagnosis and appropriate therapy of the non-motor aspects of the disease are required for adequately improvement of QoL of patients.
The efficacy of ipidacrine in patients with diabetic polyneuropathy
Authors: Kamchatnov P. R. , Barantsevich E. R. , Chugunov A. V. , Kabanov A. A. , Abusueva B. A. 
Published: June 2022

Peripheral nervous system involvement in patients with type 2 diabetes mellitus is a severe complication associated with a decrease in the quality of life, the development of disability and lethal outcomes. The most negative in terms of prognosis is autonomic diabetic polyneuropathy (DPN).Objective: to study the effectiveness of the drug ipidacrine (Ipigrix) in patients with DPN.Patients and methods. 49 patients with DPN were observed, they were divided into three groups. Patients of the 1st group (n=16) received ipidacrine 20 mg orally 3 times a day for 60 days, patients of the 2nd group (n=17) received ipidacrine 15 mg 1 time per day intramuscularly for 15 days, then – 20 mg 3 times a day orally up to 2 months; patients of the 3rd group (n=16) received only basic therapy. The clinical condition, severity of pain syndrome according to the Neurological Symptoms Score (NSS), vegetative tests, and treatment tolerance were assessed.Results and discussion. The therapy was effective in terms of reducing the severity of neuropathic pain syndrome, as well as normalizing the results of vegetative tests. In patients of the 1st group, the total scores on the NSS scale decreased by 37% (p<0.05) by the 60th day of treatment. In patients of the 2nd group, the total scores on the NSS scale decreased by 22% by the 30th day (p<0.05) and by 35% (p<0.05) by the 60th day of treatment. A pronounced positive effect in terms of vegetative tests was noted on the 60th day of treatment in the 1st and 2nd groups of patients. No adverse events were observed during the treatment period in any of patients of the 1st and the 2nd groups. In the comparison group, there were no significant changes in scores on the NSS scale and indicators of vegetative samples.Conclusion. The effectiveness of the drug ipidacrine (Ipigrix) in patients with pain and vegetative manifestations of DPN was noted.
Hemimasticatory spasm: possibilities of treatment with injections of botulinum neuroprotein type A (case report)
Authors: Valieva L. U. , Pankratov A. S. , Orlova O. R. 
Published: June 2022

Objective: to study the possibilities and effectiveness of treatment of patients with hemimasticatory spasm (HMS) with injections of botulinum neuroprotein type A (BNPA). The authors present a clinical case of long-term HMS: a 50-year-old patient, who suffered from the age of 20 from frequent involuntary muscle contractions that occurred in the temporal and masticatory muscles of the left half of the face. The patient was observed by neurologists for a long time, while the prescribed therapy did not have a satisfactory result. In the process of a comprehensive examination of the patient, in addition to intense involuntary contraction and pronounced hypertrophy of the affected muscles, secondary compensatory changes in other masticatory muscles were revealed, both on the side of the lesion and on the opposite side. BNPA treatment led to a robust improvement in the patient's condition.For patients with a long course of HMS and hypertrophy of the muscles involved in the pathological process, the use of bilateral injections of BNPA is the method of choice, since it not only effectively reduces the number of episodes, but also restores muscle balance, and also restores the motor function of the entire masticatory muscle group.
Agentive engagement in intercultural communication by L2 English-speaking international faculty and their L2 English-speaking host colleagues
Authors: Kang Dae-Min 
Published: June 2022

Abstract
The present study investigated agentive one-on-one intercultural communication between L2 English-speaking international faculty and their L2 English-speaking host colleagues in relation to identity (re)construction. Two foreign professors and their Chinese faculty colleagues participated in the study. The research instruments consisted of reflective journal writing and in-depth, semi-structured interviews. The results indicated that the occasions of the faculty’s communication at Chinese universities were both influenced by and influenced a number of factors. These factors represented self- and other-positioning, agency, appropriation of native speakerism, face-threatening acts, and alterity. Based on the findings of the study, research implications are provided.
Recent modified air-assisted liquid–liquid microextraction applications for medicines and organic compounds in various samples: A review
Authors: Azooz Ebaa Adnan , Al-Wani Huda Ssafaa Abdulwahhab , Gburi Muna Shakir , Al-Muhanna Estabraq Hassan Badder 
Published: June 2022

Abstract
Air-assisted liquid–liquid microextraction (AALLME) is a procedure for sample preparation that has high recoveries and high preconcentration factors while using a small amount of extractants. This procedure has gained widespread acceptance among scientists due to a variety of advantages, including its easiness, being cheap, green, and available in most laboratories. The current review has focused on the analysis of medicines and organic compounds using various modes of AALLME. The use of various extractants and support factors were developed in many modes of AALLME. A review of literature revealed that the procedure is used as a powerful and efficient approach for extracting medicals and organic compounds. This review explained 12 different types of AALLME methods. The findings on the modifications of AALLME modes that have been published are summarized. Future directions are also being discussed.
An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae
Authors: Umesh Madhusudhan , Singaravelu Vidya , Daulatabad Vandana , Kamble Prafull , Singhal Anish , John Nitin Ashok , John Jyoti 
Published: June 2022

Abstract
Many studies conducted after the pandemic period revealed that, while COVID-19 primarily injured the lungs, it also affects other organs in the form of cardiovascular complications, metabolic derangements, renal damage, and so on. Although we know that inflammatory cascades, complement activation, and pro-inflammatory cytokines are all involved in vasculitic processes that cause organ damage, we do not know the exact mechanism of complications such as acute respiratory distress syndrome (ARDS), cardiovascular ischemia, deep vein thrombosis, pulmonary thromboembolism, and brain injuries (embolism) that are frequently observed in COVID 19. The currently available biomarkers do not predict the severity of the aforementioned complications. As a result, more specific biomarkers such as serum calcium binding protein (S100B), glial fibrillary acid protein (GFAP), myelin basic protein (MBP), neuron-specific enolase (NSE), hs-TNI, (highly sensitive cardiac troponin) – HBDH, (Hydroxybutyrate Dehydrogenase), CK-MB (creatine kinase myocardial band), ST2 (suppression of tumorigenicity 2) are in need for early detection & improved clinical outcome.
Transfer RNA processing – from a structural and disease perspective
Authors: Sekulovski Samoil , Trowitzsch Simon 
Published: June 2022

Abstract
Transfer RNAs (tRNAs) are highly structured non-coding RNAs which play key roles in translation and cellular homeostasis. tRNAs are initially transcribed as precursor molecules and mature by tightly controlled, multistep processes that involve the removal of flanking and intervening sequences, over 100 base modifications, addition of non-templated nucleotides and aminoacylation. These molecular events are intertwined with the nucleocytoplasmic shuttling of tRNAs to make them available at translating ribosomes. Defects in tRNA processing are linked to the development of neurodegenerative disorders. Here, we summarize structural aspects of tRNA processing steps with a special emphasis on intron-containing tRNA splicing involving tRNA splicing endonuclease and ligase. Their role in neurological pathologies will be discussed. Identification of novel RNA substrates of the tRNA splicing machinery has uncovered functions unrelated to tRNA processing. Future structural and biochemical studies will unravel their mechanistic underpinnings and deepen our understanding of neurological diseases.
Relations in the Metaphysics of Science
Authors: Ioannidis Stavros , Psillos Stathis , Pechlivanidi Elina 
Published: June 2022

Abstract
In this paper we examine the status of relations in two prominent views in metaphysics of science, i.e. dispositionalism and structuralism, and argue that the current consensus about the metaphysics of relations, according to which relations are to be viewed as internal and as constituting no addition of being over and above their relata, needs to be re-examined. After discussing what we call internalism and externalism about relations, we show that dispositionalism and structuralism lead to opposite but equally controversial accounts of the metaphysics of relations. While we criticise some widespread versions of those views, we identify versions of dispositionalism and structuralism that we deem more promising. A core feature of both of these more promising variants is an externalist view about relations. Against the current internalist consensus, we claim that a version of externalism about relations is the view that best combines metaphysical rigour with a naturalistic stance.
The crystal structure of 3-(1-(2-((5-methylthiophen-2-yl)methylene)hydrazinyl)ethylidene)chroman-2,4-dione, C17H14N2O3S
Authors: Radulović Niko S. , Sejmanović Dragana M. , Ristić Milenko N. , Dekić Vidoslav S. , Krüger Biljana , Kahlenberg Volker , Rodić Marko V. 
Published: June 2022

Abstract
C17H14N2O3S, monoclinic, P21/c (no. 14), a = 9.8966(5) Å, b = 9.4360(4) Å, c = 16.7115(7) Å, β = 92.245(4)°, V = 1559.39(12) Å3, Z = 4, R
gt(F) = 0.0358, wR
ref(F
2) = 0.1013, T = 170 K.
Advanced energy-saving optimization strategy in thermo-mechanical pulping by machine learning approach
Authors: Talebjedi B. , Laukkanen T. , Holmberg H. , Vakkilainen E. , Syri S. 
Published: June 2022

Abstract
Thermo-mechanical Pulping (TMP) is one of the most energy-intensive industries where most of the electrical energy is consumed in the refining process. This paper proposes the energy-saving refining optimization strategy by integrating the machine learning algorithm and heuristic optimization method. First, refining specific energy consumption (RSEC) and pulp quality identification models are developed using Artificial Neural Networks. In the second step, the developed identification models are incorporated with the Genetic algorithm to minimize the total refining specific energy consumption while maintaining the same pulp quality. Simulation results prove that a deep multilayer perceptron neural network is a powerful tool for creating refining energy and quality identification models with the model correlation coefficients of 0.97, 0.94, 0.92, and 0.67 for the first-stage RSEC, second-stage RSEC, final pulp fiber length, and freeness prediction, respectively. Findings confirm that the average total RSEC reduction of 14 % is achievable by utilizing the proposed optimization method.
Preparation of carbosilane quaternary ammonium surfactants and surface activity
Authors: Liu Xue-Li , Chen Yi-Fan , Chen Yi-Wen , Peng Wei-Kang , Liu Han-Chun 
Published: June 2022

Abstract
A new series of carbosilane quaternary ammonium surfactants with different hydrophobic carbosilane structures (triethylsilyl, triisopropylsilyl, trihexylsilyl, triphenylsilyl) and tail groups (C12, C16, C18) have been synthesized and the structures of the organosilicon carbosilane quaternary ammonium surfactants were determined by means of FTIR, NMR and elemental analysis. The properties of aqueous solutions were determined by electrical conductivity measurements and with the method of maximum bubble formation. Members of this series reduced the surface tension of water to approximately 30.5 mN/m at concentration levels of 0.14 mmol/L.
Compounding Optimization of SBS-SBR High-Viscosity Modifier and Rejuvenation of Aged SBS-SBR Modified Asphalt
Authors: Zhu Yajing , Xu Guangji , Ma Tao , Fan Jianwei 
Published: June 2022

Abstract
In this paper, the modification effects of the styrene-butadiene rubber (SBR) high-viscosity modifier (HVM) with different monomer compositions and the HVMs with different styrene-butadiene-styrene block copolymer (SBS)-SBR compound ratios were explored. On this basis, the rejuvenation effects of representative rejuvenator components on slightly and severely aged high-viscosity asphalt (HVA) were studied through molecular dynamics simulations. The results show that when the proportion of 1,4-polybutadiene in the SBR molecule remains unchanged, increasing the proportion of cis-1,4-polybutadiene is slightly disadvantageous to its compatibility with the matrix asphalt, while the mechanical properties of the prepared HVA are less affected. Increasing the content of 1,2-polybutadiene and polystyrene monomer in the SBR molecule is not conducive to its compatibility with the matrix asphalt, but it increases the mechanical properties of the prepared HVA. When the compound ratio is between 4 % SBS + 8 % SBR and 8 % SBS + 4 % SBR, both the diffusion state of the modifier in the matrix asphalt and the compatibility of the compound HVM with the matrix asphalt are the best, and it is most conducive to the cross-linked structure formation between the HVM and matrix asphalt. Among the representative rejuvenator molecules, p-xylene has the strongest interaction with aged HVA and it has the strongest permeability in aged HVA. Nonanal is most conducive to improve the self-aggregation of asphaltenes in aged HVA. During the miscibility stage, n-hexane molecules are more likely to appear around the aged HVA molecules, which is beneficial to the rejuvenator to repair and improve the performance of the aged HVA and form a stable structure. The research results provide references for the monomer optimization of SBR HVM, the determination of the optimal compound ratio of SBS-SBR modifier, and the rejuvenation of HVA.