bluuebunny/crossref_metadata_2025_split huggingface dataset:
Обґрунтування рекомендацій щодо забезпечення енергетичної безпеки держави в рамках підвищення рівня її воєнної безпеки та стабільності національної економіки
Authors: Solomitsky Alexey , Semenenko Oleh , Onofriichuk Petro , Slyusarenko Marina , Pekuliak Roman , Hrechanyi Maksym 
Published: May 2022

Мета роботи: обґрунтування рекомендацій щодо забезпечення енергетичної безпеки держави для підвищення національної (воєнної) безпеки.
Дизайн/Метод/Підхід дослідження: використовується метод інверсного аналізу складових енергетичного сектору, визначення критичних параметрів та розроблення шляхів їх подолання (нівелювання).
Практична цінність дослідження: запропоновані рекомендації можливо використовувати під час розроблення програмних документів щодо розвитку енергетичної сфери держави, визначення шляхів протистояння негативним зовнішнім та внутрішнім факторам. Запропоновані рекомендації дозволять: покращити становище, яке склалося в енергетичному секторі, зокрема внаслідок бойових дій; зменшити уразливість енергетичного сектору від дії зовнішніх та внутрішніх факторів; дозволять зробити процеси, що відбуваються в енергетичному секторі, більш керованими; підвищити загальний рівень національної та воєнної безпеки держави, у частині, що залежить від енергетичної безпеки; розробляти рекомендації керівництву держави щодо завчасного реагування на загрози в енергетичній сфері.
Тип статті: теоретична.
Організаційно-правові аспекти обліку надходжень благодійних пожертв у Збройних силах України в умовах воєнного стану
Authors: Voloshenko Antonina 
Published: May 2022

Мета роботи: розробка практичних рекомендацій із зменшення ризиків нецільового використання надходжень благодійної допомоги у військових частинах на підставі дослідження організаційно-правових аспектів обліку благодійних пожертв в умовах воєнного стану.
Дизайн/Метод/Підхід дослідження: дослідження проводилося з використанням наступних загальнонаукових та спеціальних методів: метод аналізу і синтезу в їх системному поєднанні під час вивчення офіційних документів національної нормативно-правової бази; статистичні методи під час дослідження показників благодійної діяльності; абстрактно-логічний метод − для формулювання теоретичних узагальнень і висновків дослідження. Робота виконана особисто автором.
Результати дослідження: статті досліджено організаційно-правові аспекти обліку надходжень благодійних пожертв у Збройних Силах України в умовах воєнного стану. Визначено, що допомога є благодійною у випадку одночасного дотримання критеріїв добровільності, цілеспрямованості та безкорисності. Встановлено, що благодійна допомога, з метою фінансового забезпечення потреб національної оборони держави, надається за рахунок благодійних пожертв фізичних та юридичних осіб, може здійснюватися як індивідуально, так і колективно, шляхом безоплатної передачі коштів та/або майна в натуральній формі. Акцентовано увагу на ризики нецільового використання благодійних пожертв у натуральній формі через суперечливість норм чинного законодавства.
Теоретична цінність дослідження: Обґрунтовано доцільність визначення на нормативному рівні військовим формуванням повноважень із встановлення внутрішньовідомчими нормативно-правовими актами норм щодо отримання, використання, обліку та звітності благодійної допомоги, з урахуванням особливостей здійснення зазначених процесів в умовах ведення бойових дій.
Практична цінність дослідження: полягає у розробці та формулюванні системних узагальнень та конкретних пропозицій щодо вдосконалення системи обліку та контролю руху благодійних пожертв у Збройних Силах України.
Тип статті: науково-практична.
The Design and Feasibility of the: Radial Artery Puncture Hemostasis Evaluation – RAPHE Study, a Prospective, Randomized, Multicenter Clinical Trial
Authors: Kulyassa Péter , Németh Balázs T. , Ehrenberger Réka , Ruzsa Zoltán , Szük Tibor , Fehérvári Péter , Engh Marie Anne , Becker Dávid , Merkely Béla , Édes István F. 
Published: May 2022

Introduction and AimRadial artery approach angiography is the current gold standard for coronary status diagnostics and eventual percutaneous revascularization (PCI). Currently, application of adequate, patent hemostasis based physical torniquets are used for puncture site control, to avoid bleeding, radial artery occlusion and damage (RAO and RAD). The Radial Artery Puncture Hemostasis Evaluation (RAPHE) is a prospective, randomized, multicenter clinical trial designed to investigate new, simplified techniques of radial artery hemostasis utilizing physical compression free methods.Methods and ResultsThe RAPHE study has been designed to evaluate the efficacy and safety of two non-compression based radial artery hemostasis methods: a 100% chitosan bioactive hemostatic dressing and a purpose-built radial potassium-ferrate based topical hemostasis disc. These devices will be investigated in a standalone configuration. Control group is a standard pneumatic airbladder-based compression device. A total of 600 patients will be enrolled in a three-way randomization (1:1:1) with two study and one control groups. Safety and efficacy endpoints are RAO, puncture site hematoma formation and RAD respectively, consisting of dissection, (pseudo)aneurism and/or fistula formation, measured post-procedure and at sixty days.ConclusionThe results from this trial will provide valuable information on new, simplified methods of radial artery hemostasis options and possibly simplify post-puncture management of patients.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT04857385].
Comparative Analysis of Physical Activity Detected via an External Accelerometer and Cardiac Implantable Electronic Devices
Authors: Chen Chun-Kai , Cheng Li-Ying , Hsu Shan-Wei , Liao Min-Tsun , Ku Po-Wen , Liu Yen-Bin 
Published: May 2022

BackgroundPhysical activity (PA) has become an important health issue for decades. Cardiovascular implantable electronic devices (CIEDs) have built-in PA-recording functions. We aimed to compare PA measurements using an external accelerometer (ActiGraph GT3X+) and internal accelerometers (Abbott, Biotronik, and Medtronic CIEDs).MethodsThis was a prospective, single-center observational study. The device-measured 7-day average PA was collected, and GT3X+ -measured 7-day average PA was used as the gold-standard, including all daily observations of activity. Pearson’s correlation coefficients were used to compare the correlations between GT3X+ -measured and CIED-measured PA. Bland-Altman plots were used to analyze measurement agreement, and intraclass correlation coefficients were used to analyze reliability.ResultsIn total, 720 patients treated with CIEDs were surveyed between November 2020 and April 2021, 60 of them were analyzed after patient screening by our protocol. Each manufacturer included 20 patients for the final analysis. The CIED-measured PAs of Abbott, Biotronik, and Medtronic were 3.0 ± 1.5, 2.6 ± 1.8, and 3.8 ± 2.5 h per day, respectively; the GT3X+ -measured PAs were 6.9 ± 2.8, 6.0 ± 2.4, and 6.4 ± 2.5 h per day, respectively. Moderate and significant correlations were found in patients using Abbott, Biotronik, and Medtronic CIEDs (r = 0.534, p = 0.015; r = 0.465, p = 0.039; r = 0.677, p = 0.001, respectively). Bland-Altman plots and intraclass correlation coefficients both showed a significant correlation and reliability between the average PA measured by GT3X+ and CIEDs (hours per day).ConclusionAlthough the PA recording function of CIEDs includes a single-axis accelerometer, it has a moderate correlation compared with the triaxial accelerometer of the GT3X+. However, CIEDs seem to underestimate PA for 3–4 h compared to the GT3X+.
The Seismogenic Potential of the Southernmost Ryukyu Subduction Zone as Revealed by Historical Earthquakes and Slow Slip events
Authors: Chen Sean Kuanhsiang , Wu Yih-Min , Chan Yu-Chang 
Published: May 2022

The southernmost Ryukyu subduction zone may have a geodetically inferred Mw 7.5 to 8.7 megathrust earthquake in a shallow locked region, the Ryukyu fault. Paleoseismological evidence of historical earthquakes available from the last 417 years indicates that only a 1920 Mw 7.7 earthquake occurred within this magnitude range, near the downdip end of the Ryukyu fault. As slow slip events downdip the locked seismogenic zone may trigger a large subduction earthquake, we investigate how the first observed slow slip events in 2005, 2009, and 2015 initiated downdip in the Ryukyu fault interface affect the occurrence of a megathrust. We establish possible megathrust earthquake cycles from Mw 7.5 to 8.7 on the Ryukyu fault using constraints from the magnitude-frequency relation based on local historical earthquakes. This analysis shows a b value of 1.2 for magnitudes greater than Mw 7.0, which is higher than the empirical 1.0 value. This indicates that the recurrence of an event up to Mw 8.7 is longer than previously thought if the megathrust events follow the observed magnitude-frequency relation. Then, we quantify the influence of slow slip events on the triggering of a potential megathrust earthquake by calculating the static stress increase. We find that stress perturbations caused by the three slow slip events are generally consistent with the values that have triggered the large interplate earthquakes in several subduction zones. However, a large earthquake has not yet been triggered on the Ryukyu fault after a sequence of slow slip events. If the 1920 Mw 7.7 earthquake is the last rupture of the Ryukyu fault, the earthquake cycle on the Ryukyu fault is very likely in an early stage. However, this is not true if the slow slip events occur toward the end of the earthquake cycle and there has been no megathrust earthquake at the fault interface in the last 417 years, as the 2011 Mw 9.0 Tohoku earthquake. Thus, higher potential for a megathrust earthquake may occur in the southernmost Ryukyu subduction zone.
The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis
Authors: Chen Yidan , Lv Xingfei , Lin Sang , Arshad Mohammad , Dai Mengjun 
Published: May 2022

AimsThis study aimed to assess the impact of different antidiabetic agents on individuals with diabetes and COVID-19.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to October 31, 2021 and included seven antidiabetic agents. The data were pooled via traditional pairwise meta-analysis and Bayesian network meta-analysis.ResultsThe pairwise meta-analysis included 35 studies. Metformin (odds ratio (OR), 0.74; P=0.001), dipeptidyl peptidase-4 inhibitors (DPP4i) (OR, 0.88; P=0.04), sodium-glucose cotransporter-2 inhibitors (SGLT2i) (OR, 0.82; P=0.001), and glucagon-like peptide-1 receptor agonists (GLP1RA) (OR, 0.91; P=0.02) treatment were associated with lower COVID-19 mortality in individuals with diabetes compared to respective non-users. However, insulin treatment resulted in higher mortality (OR, 1.8; P=0.001). Mortality did not significantly differ in sulfonylurea (OR, 0.97; P=0.56) and thiazolidinediones (TZDs) (OR, 1.00; P=0.96) users. Furthermore, due to limited data, we analyzed five antidiabetic agents (metformin, DPP4i, sulfonylurea, insulin, and SGLT2i) and found no association between them and severe disease risk (all P&gt;0.05). The Bayesian network meta-analysis included 18 studies. GLP1RA and SGLT2i had the highest first and second rank probability (67.3% and 62.5%, respectively). Insulin showed the maximum probability of ranking seventh (97.0%). Metformin had the third and fourth highest rank probability of 44.8% and 38.9%, respectively. Meanwhile, DPP4i had the fifth-highest rank probability of 42.4%, followed by sulfonylurea at 45.1%.ConclusionMetformin, DPP4i, SGLT2i, and GLP1RA treatments were highly possible to reduced COVID-19 mortality risk in individuals with diabetes, while insulin might be related to increased mortality risk. Sulfonylurea and TZDs treatments were not associated with mortality. None of the antidiabetic agents studied were associated with the risk of severe disease. Additionally, GLP1RA probably had the most significant protective effect against death, followed by SGLT2i and metformin.Systematic Review RegistrationPROSPERO (CRD42021288200)
Variability in Phelan-McDermid Syndrome in a Cohort of 210 Individuals
Authors: Nevado Julián , García-Miñaúr Sixto , Palomares-Bralo María , Vallespín Elena , Guillén-Navarro Encarna , Rosell Jordi , Bel-Fenellós Cristina , Mori María Ángeles , Milá Montserrat , Campo Miguel del , Barrúz Pilar , Santos-Simarro Fernando , Obregón Gabriela , Orellana Carmen , Pachajoa Harry , Tenorio Jair Antonio , Galán Enrique , Cigudosa Juan C. , Moresco Angélica , Saleme César , Castillo Silvia , Gabau Elisabeth , Pérez-Jurado Luis , Barcia Ana , Martín Maria Soledad , Mansilla Elena , Vallcorba Isabel , García-Murillo Pedro , Cammarata-Scalisi Franco , Gonçalves Pereira Natálya , Blanco-Lago Raquel , Serrano Mercedes , Ortigoza-Escobar Juan Dario , Gener Blanca , Seidel Verónica Adriana , Tirado Pilar , Lapunzina Pablo ,   Spanish PMS Working Group
Published: May 2022

Phelan-McDermid syndrome (PMS, OMIM# 606232) results from either different rearrangements at the distal region of the long arm of chromosome 22 (22q13.3) or pathogenic sequence variants in the SHANK3 gene. SHANK3 codes for a structural protein that plays a central role in the formation of the postsynaptic terminals and the maintenance of synaptic structures. Clinically, patients with PMS often present with global developmental delay, absent or severely delayed speech, neonatal hypotonia, minor dysmorphic features, and autism spectrum disorders (ASD), among other findings. Here, we describe a cohort of 210 patients with genetically confirmed PMS. We observed multiple variant types, including a significant number of small deletions (&lt;0.5 Mb, 64/189) and SHANK3 sequence variants (21 cases). We also detected multiple types of rearrangements among microdeletion cases, including a significant number with post-zygotic mosaicism (9.0%, 17/189), ring chromosome 22 (10.6%, 20/189), unbalanced translocations (de novo or inherited, 6.4%), and additional rearrangements at 22q13 (6.3%, 12/189) as well as other copy number variations in other chromosomes, unrelated to 22q deletions (14.8%, 28/189). We compared the clinical and genetic characteristics among patients with different sizes of deletions and with SHANK3 variants. Our findings suggest that SHANK3 plays an important role in this syndrome but is probably not uniquely responsible for all the spectrum features in PMS. We emphasize that only an adequate combination of different molecular and cytogenetic approaches allows an accurate genetic diagnosis in PMS patients. Thus, a diagnostic algorithm is proposed.
Evaluation of Patients With Cognitive Impairment Due to Suspected Idiopathic Normal-Pressure Hydrocephalus at Medical Centers for Dementia: A Nationwide Hospital-Based Survey in Japan
Authors: Kazui Hiroaki , Hashimoto Mamoru , Takeda Shigetoshi , Chiba Yasuji , Goto Tokiko , Fuchino Katsuhiro 
Published: May 2022

ObjectiveTreatment of idiopathic normal-pressure hydrocephalus (iNPH) requires collaboration between dementia specialists and neurosurgeons. The role of dementia specialists is to differentiate patients with iNPH from patients with other dementia diseases and to determine if other dementia diseases are comorbid with iNPH. We conducted a nationwide hospital-based questionnaire survey on iNPH in medical centers for dementia (MCDs).MethodsWe developed a questionnaire to assess how physicians in MCDs evaluate and treat patients with cognitive impairment due to suspected iNPH and the difficulties these physicians experience in the evaluation and treatment of patients. The questionnaire was sent to all 456 MCDs in Japan.ResultsQuestionnaires from 279 MCDs were returned to us (response rate: 61.2%). Patients underwent cognitive tests, evaluation of the triad symptoms of iNPH, and morphological neuroimaging examinations in 96.8, 77.8, and 98.2% of the MCDs, respectively. Patients with suspected iNPH were referred to other hospitals (e.g., hospitals with neurosurgery departments) from 78.9% of MCDs, and cerebrospinal fluid (CSF) tap test was performed in 44 MCDs (15.8%). iNPH guidelines (iNPHGLs) and disproportionately enlarged subarachnoid space hydrocephalus (DESH), a specific morphological finding, were used and known in 39.4% and 38% of MCDs, respectively. Logistic regression analysis with “Refer the patient to other hospitals (e.g., hospitals with neurosurgery departments) when iNPH is suspected.” as the response variable and (a) using the iNPHGLs, (b) knowledge of DESH, (c) confidence regarding DESH, (d) difficulty with performing brain magnetic resonance imaging, (e) knowledge of the methods of CSF tap test, (f) absence of physician who can perform lumbar puncture, and (g) experience of being told by neurosurgeons that referred patients are not indicated for shunt surgery as explanatory variables revealed that the last two factors were significant predictors of patient referral from MCDs to other hospitals.ConclusionSufficient differential or comorbid diagnosis using CSF tap test was performed in a few MCDs. Medical care for patients with iNPH in MCDs may be improved by having dementia specialists perform CSF tap tests and share the eligibility criteria for shunt surgery with neurosurgeons.
Bitter Orange (Citrus aurantium L.) Intake Before Submaximal Aerobic Exercise Is Safe for Cardiovascular and Autonomic Systems in Healthy Males: A Randomized Trial
Authors: Benjamim Cicero Jonas R. , Júnior Francisco Welington de Sousa , Porto Andrey Alves , Rocha Élida Mara B. , Santana Milana D. , Garner David M. , Valenti Vitor E. , Bueno Júnior Carlos Roberto 
Published: May 2022

BackgroundThere are still no studies of the cardiovascular safety of the isolated use of Citrus aurantium in aerobic submaximal exercise.ObjectiveTo evaluate the effect of C. aurantium supplementation on the recovery of cardiorespiratory and autonomic parameters following a session of submaximal aerobic exercise.MethodsTwelve healthy male adults achieved a crossover, randomized, double-blind, and placebo-controlled trial. C. aurantium (600 mg, p-synephrine at 30% amount [180 mg]) or placebo (600 mg of starch) were ingested 90 min before evaluation in randomized days. We evaluated systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), heart rate (HR) and, HR variability indexes at Rest and during 60 min of recovery from exercise.ResultsCitrus aurantium ingestion accelerated the reduction in SBP after exercise, anticipated the return of vagal modulation of the heart after exercise via the HF (ms2), pNN50 (%), and 2 UV% indices. Moreover, rushed the output of sympathetic modulation after exercise via the 0V% index. No unfavorable cardiovascular effects were achieved for HR, DBP, PP, and MAP parameters.ConclusionsCitrus aurantium was shown to be safe for the cardiovascular and autonomic systems alongside submaximal aerobic exercise in healthy males.
Complications of Endoscopic Skull Base Surgery for Sellar and Parasellar Tumors in Pediatric Population; Neurosurgical Perspectives
Authors: Yang Jeyul , Kim Yong Hwy , Phi Ji Hoon , Kim Seung-Ki , Wang Kyu-Chang 
Published: May 2022

BackgroundAdvances in surgical techniques based on in-depth anatomical knowledge of the skull base have broadened the indications for endoscopic skull base surgery (ESS) with the advantage of wide and direct surgical exposure while minimizing invasiveness. However, the low incidence of the indicated diseases and narrow surgical corridors in children have limited the popularization of ESS. In addition, surgical complications and preventive interventions are not yet well known. Therefore, we retrospectively investigated the complications and prevention methods of ESS in children with a comprehensive review.MethodsWe retrospectively analyzed the medical records of pediatric patients who underwent ESS for sellar and parasellar tumors at Seoul National University Children’s Hospital from July 2010 to December 2020. Visual and endocrine status, extent of resection, complications, and recurrences were investigated depending on the pathology of the tumor. In addition, a comprehensive literature review regarding the complications of pediatric ESS was performed.ResultsA total of 98 patients were enrolled. The median age of the patients was 12 years, and 52 patients were male. Preoperative visual disturbance was found in 53 patients, anterior pituitary function deficit in 69, and diabetes insipidus in 32. Gross total resection was attempted in 67 patients and achieved in 62 (93%). Biopsy and cyst fenestration were the goals of surgery in 26 patients, and all were achieved as planned. Regarding outcomes, visual disturbance worsened in two patients (2%), endocrine status was aggravated in 34 (35%) patients, and new-onset diabetes insipidus occurred in 27 (41%) patients. The overall surgical complication rate (other than aggravation of visual or endocrine status) was 17%. Postoperative meningitis (12%) was the most common complication, followed by cerebrospinal fluid leakage (2%), vasospasm, hemorrhage and infarction. By pathological diagnosis, craniopharyngioma had the highest complication rate of 29%. All but one patient with postoperative hemorrhage showed no permanent deficits.ConclusionESS in children is feasible and relatively safe. More attention and different postoperative management protocols are required in children to avoid complications, especially in craniopharyngiomas. However, the complications can be mostly managed conservatively without permanent neurologic deficits.
Gastrointestinal Endoscopy Performed by Gastroenterologists: Opportunistic Screening Strategy for Newly Diagnosed Head and Neck Cancers
Authors: Yang Chih-Wei , Chu Yueng-Hsiang , Chen Hsin-Chien , Huang Wei-Chen , Chen Peng-Jen , Chang Wei-Kuo 
Published: May 2022

AimApproximately 66% of head and neck cancers are diagnosed at an advanced stage. This prospective study aimed to detect newly diagnosed head and neck cancers using regular upper gastrointestinal (UGI) endoscopy with oral-pharynx-larynx examination.MethodsA total of 2,849 patients underwent UGI endoscopy with an additional oral-pharynx-larynx examination. Patients aged &lt; 20 years, those who were pregnant, had a history of head and neck cancers, were undergoing emergency endoscopy, and had a poor laryngopharyngeal view were excluded. The symptoms, incidence, location, pathology, and stage of malignant neoplasms were investigated.ResultsA total of 2,720 patients were enrolled. Endoscopically observable 23 abnormal findings (0.85%) included 18 (0.66%) benign lesions and 5 (0.18%) newly diagnosed malignant neoplasms. Notably, 4 (80%) of 5 patients with malignant neoplasms were diagnosed at an early stage (Stage 0, I, and II).ConclusionsUGI endoscopy with oral-pharynx-larynx examination can achieve opportunistic head neck cancer screening and is recommended for every patient in endoscopy units.