bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic COVID-19 Vaccination also Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland. Criteria for COVID-19 Reimmunization Are Needed
Authors: Kosiorek Piotr , Kazberuk Dorota Elżbieta , Hryniewicz Anna , Milewski Robert , Stróż Samuel , Stasiak-Barmuta Anna 
Published: February 2022

Abstract
Systemic vaccination with the BNT162b2 mRNA vaccine stimulates the humoral response.Our study aimed to compare the intensity of the humoral immune response, measured bySARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD neutralizing IgG antibody levels, afterCOVID-19 vaccination versus after SARS-CoV-2 infection. We analyzed 1060 people in thefollowing groups: convalescents, healthy vaccinated individuals, individuals vaccinated withComirnaty, AstraZeneca, Moderna, or Johnson & Johnson, and vaccinated SARS-CoV-2convalescents. The concentrations of SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBDneutralizing antibodies were estimated in the oncology hospital laboratory bychemiluminescent immunoassay (CLIA; MAGLUMI). Results: (1) We observed a rise inantibody response in both SARS-CoV-2 convalescent and COVID-19-vaccinated groups. (2)The levels of all antibody concentrations in vaccinated COVID-19 convalescents weresignificantly higher. (3) We differentiated asymptomatic SARS-CoV-2 convalescents from thecontrol group. Our analysis suggests that monitoring SARS-CoV-2 IgG antibodyconcentrations is essential as an indicator of asymptomatic COVID-19 and as a measure of theeffectiveness of the humoral response in convalescents and vaccinated people. Considering thetime-limited effects of post-SARS-CoV-2 infection recovery or vaccination and thephysiological half-life, among other factors, we suggest monitoring the IgG antibody level as acriterion for the next vaccination.
PEACEFUL JIHĀD DAN PENDIDIKAN DERADIKALISASI AGAMA
Authors: Sulasman Sulasman 
Published: February 2022

The Islamic Boarding School (Pondok Pesantren) Miftahul Huda was originatelly identical with the radicalism movement not only because of its exclusivism in religious activities, the criticism toward the government, but also the identification of its members with DI/TII movement and FPI. In line with internal and external dynamics, this boarding school reoriented its movement from physical jihād to the path of education and peaceful dakwah or in Lukens-Bull’s perspective it is so-called peaceful jihād. The process of self-domestication and the movement of de-radicalization in this boarding was executed by six ways. They are internalizing the values of boarding school, increasing the Islamic perspective, adopting schools system, providing the education of hubb al-waṭan, using local wisdom, and developing skill education. The strategy of de­-radicalization applied by Miftahul Huda Islamic Boarding School is divided into three efforts; preventive de-radicalization, preservative de-radicalization, and curative de-radicalization. The results was shown that the students, alumni, and the boarding schools incorporated in Miftahul Huda Islamic boarding school networking system that appears in peace, moderate, and tolerance appearance.***Pondok Pesantren Miftahul Huda semula identik dengan gerakan “radikal” baik karena pandangan eksklusivismenya dalam beragama, kritisisme terhadap Pemerintah, maupun karena keidentikkan beberapa personalnya dengan gerakan DI/TII dan FPI. Sejalan dengan dinamika internal dan eksternal, pondok pe­santren ini pun mereorientasi gerakannya dari jihād fisik ke jalur pendidikan dan dakwah damai atau dalam perspektif Lukens-Bull dikenal sebagai jihad damai (peaceful jihād). Proses menjinakkan diri dan gerakannya, yang dikenal dengan deradikalisasi, dilalui oleh pondok pesantren ini dengan enam cara, yakni inter­nali­sasi nilai-nilai pesantren, perluasan perspektif keislaman, adopsi sistem sekolah, pendidikan hubb al-waṭan, penggunaan local wisdom, dan pendidikan keterampilan. Upaya deradikalisasi yang dilakukan Pondok Pesantren Miftahul Huda berkisar pada tiga strategi, yakni pencegahan, pemeliharaan budaya damai, dan pemulihan bagi yang terdampak radikal. Hasilnya, para santri, alumni, dan pesantren yang tergabung dalam sistem jaringan Pondok Pesantren Miftahul Huda muncul dalam wajah damai, moderat, dan toleran.
Recent Developments in Pyrazofurin Analogue Design
Authors: Chen X. , Sauer D.R. , Schnellert S.W. 
Published: February 2022

Abstract:
Nucleosides of 5-membered heterocycles are playing a prominent role in the design of antiviral agents. Included in this group is 4- hydroxy-3-( -D-ribofuranosyl)pyrazole-5-carboxamide (pyrazofurin), which is a naturally occurring C-nucleoside that shows significant broad spectrum in vitro antiviral activity against DNA and RNA viruses. The extent of its antiviral properties is represented by its activity against pox-, picorna, toga-, myxo-, rhabdo-, arena-, and bunyaviruses with a high degree of selectivity. Even with its promising activity and broad safety margin in cell cultures, there have been reports that the toxicity of pyrazo­ furin may limit its usefulness as an antiviral agent. However, others have suggested that the toxicity of pyrazofurin is unlikely to be associated with the structural components that are responsible for its antiviral properties. To evaluate this suggestion for the purpose of producing non-toxic pyrazofurin-derived agents that are effective against the virus groups mentioned above, structural modifications in pyrazofurin have recently been the subject of work in this laboratory. These efforts are described.
Development of Agents to Modulate the Effects of Endothelin
Authors: Cheng X.-M. , Nikam S.S. , Doherty A.M. 
Published: February 2022

Abstract:
Due partly to a greater understanding of the role of regulatory peptides and proteins in the pathophysiology of human disease there is considerable interest in designing agents that will modulate their effects. Endothelin-1 and its isopeptides belong to a family of novel vasoconstrictor agents first isolated from porcine aortic endothelial cells and subsequently found to be secreted from a variety of cell types. These peptides have potent biological effects on cardiovascular, renal, endocrine and neurological function. The rational design of receptor agonists and antagonists or proce­
ssing inhibitors from a ligand of interest, requires an understanding of the binding mode of the
natural ligand(s) to the receptor(s) or enzyme and the relative importance of individual residues to binding. Screening of compound libraries and lead optimization techniques have also lead to pote'lt antagonists and processing enzyme inhibitors. This review will describe the progress
achieved to date using both of these techniques to discover novel and potent endothelin agonists and antagonists of differing selectivity for the known ET receptor subtypes. Progress towards to design of endothelin converting enzyme inhibitors is also discussed. the discovery of agents to modulate the effects of endothelin will prove useful in elucidating the role of the endothelin family of peptides in human physiology and pathophysiology.
A new perspective on the treatment of Alzheimer's disease and sleep deprivation-related conse-quences: Curcumin
Authors: Akkol Esra Küpeli , Bardakcı Hilal , Yücel Çiğdem , Karatoprak Gökçe Şeker , Karpuz Büşra , Khan Haroon , Khayatkashani Maryam , Alizadeh Pooyan , Kashani Hamid Reza Khayat 
Published: February 2022

Abstract:
Sleep problems and Alzheimer's Disease (AD) are two disorders often seen together. Age-related structural and physiological changes in certain parts of the brain lead to changes in sleep patterns. Conditions such as AD also affect these areas of the brain, thus changing the sleep-wake cycle. Sleep disorders likewise adversely affect the course of the disease. Sleep quality is important for the proper functioning of the memory. Impaired sleep is also associated with problems in some areas of the brain that play a key role in learning and memory functions. Changes in the brain seen in aging and AD disrupt sleep and memory processes, leading increased cognitive impairment. In addition to synthetic drugs, treatment with plants has also become a preferred factor in the treatment. Curcuminoids, which are in the structure of diarylheptanoid, are the main components of turmeric. Curcumin has multiple applications in treatment regimes of various diseases such as cardiovascular diseases, obesity, cancer, inflammatory diseases, and aging. Besides these applications and activities, curcumin has been reported to be effective in many neurodegenerative diseases. There are plenty of studies show-ing that curcumin can lead significant improvements in the pathological process of AD. Despite many important positive effects, the therapeutic limitation of curcumin is its low solubility and bioavailabil-ity. New approaches are needed to solve this problem and many studies have focused different types of advanced nanoformulations. This review summarizes the available scientific data, as reported by the most recent studies describing the treatment of Alzheimer's Disease and sleep deprivation-related consequences.
Readiness to Embrace Artificial Intelligence Among Medical Doctors and Students: Questionnaire-Based Study
Authors: Boillat Thomas , Nawaz Faisal A , Rivas Homero 
Published: February 2022

Background
Similar to understanding how blood pressure is measured by a sphygmomanometer, physicians will soon have to understand how an artificial intelligence–based application has come to the conclusion that a patient has hypertension, diabetes, or cancer. Although there are an increasing number of use cases where artificial intelligence is or can be applied to improve medical outcomes, the extent to which medical doctors and students are ready to work and leverage this paradigm is unclear.

Objective
This research aims to capture medical students’ and doctors’ level of familiarity toward artificial intelligence in medicine as well as their challenges, barriers, and potential risks linked to the democratization of this new paradigm.

Methods
A web-based questionnaire comprising five dimensions—demographics, concepts and definitions, training and education, implementation, and risks—was systematically designed from a literature search. It was completed by 207 participants in total, of which 105 (50.7%) medical doctors and 102 (49.3%) medical students trained in all continents, with most of them in Europe, the Middle East, Asia, and North America.

Results
The results revealed no significant difference in the familiarity of artificial intelligence between medical doctors and students (P=.91), except that medical students perceived artificial intelligence in medicine to lead to higher risks for patients and the field of medicine in general (P<.001). We also identified a rather low level of familiarity with artificial intelligence (medical students=2.11/5; medical doctors=2.06/5) as well as a low attendance to education or training. Only 2.9% (3/105) of medical doctors attended a course on artificial intelligence within the previous year, compared with 9.8% (10/102) of medical students. The complexity of the field of medicine was considered one of the biggest challenges (medical doctors=3.5/5; medical students=3.8/5), whereas the reduction of physicians’ skills was the most important risk (medical doctors=3.3; medical students=3.6; P=.03).

Conclusions
The question is not whether artificial intelligence will be used in medicine, but when it will become a standard practice for optimizing health care. The low level of familiarity with artificial intelligence identified in this study calls for the implementation of specific education and training in medical schools and hospitals to ensure that medical professionals can leverage this new paradigm and improve health outcomes.
Utilizing Big Data From Google Trends to Map Population Depression in the United States: Exploratory Infodemiology Study
Authors: Wang Alex , McCarron Robert , Azzam Daniel , Stehli Annamarie , Xiong Glen , DeMartini Jeremy 
Published: February 2022

Background
The epidemiology of mental health disorders has important theoretical and practical implications for health care service and planning. The recent increase in big data storage and subsequent development of analytical tools suggest that mining search databases may yield important trends on mental health, which can be used to support existing population health studies.

Objective
This study aimed to map depression search intent in the United States based on internet-based mental health queries.

Methods
Weekly data on mental health searches were extracted from Google Trends for an 11-year period (2010-2021) and separated by US state for the following terms: “feeling sad,” “depressed,” “depression,” “empty,” “insomnia,” “fatigue,” “guilty,” “feeling guilty,” and “suicide.” Multivariable regression models were created based on geographic and environmental factors and normalized to the following control terms: “sports,” “news,” “google,” “youtube,” “facebook,” and “netflix.” Heat maps of population depression were generated based on search intent.

Results
Depression search intent grew 67% from January 2010 to March 2021. Depression search intent showed significant seasonal patterns with peak intensity during winter (adjusted P<.001) and early spring months (adjusted P<.001), relative to summer months. Geographic location correlated with depression search intent with states in the Northeast (adjusted P=.01) having higher search intent than states in the South.

Conclusions
The trends extrapolated from Google Trends successfully correlate with known risk factors for depression, such as seasonality and increasing latitude. These findings suggest that Google Trends may be a valid novel epidemiological tool to map depression prevalence in the United States.
GAMBARAN MOTIVASI KLUB MOBIL SUZUKI ERTIGA “ERCI RANGERS” DI TANGERANG
Authors: Sabir Ahmad 
Published: February 2022

Ertiga Club Indonesia ditangerang atau Rangers sebagai komunitas yang menyebut dirinya organisasi, telah menempatkan dirinya pada organisasi non profit. Karena tiap anggota adalah aset terpenting yang dimiliki oleh komunitas, maka terlibatnya anggota masuk ke organisasi menarik untuk diteliti. Seperti organisasi non profit lainnya, untuk bergabung dan terlibat ke dalam organisasi Rangers ini, anggota organisasi diwajibkan memenuhi persyaratan yang ditentukan. Tentu hal ini membutuhkan pengorbanan dari anggota Rangers. Dari berbagai pengorbanan yang dilakukan, masing-masing anggota Rangers memiliki suatu motivasi yang menyebabkan mereka terlibat dalam organisasi. Kebutuhan dianggap sebagai hal yang paling penting digunakan untuk memahami motivasi, sebab kebutuhan merupakan kekuatan utama seseorang dalam memiliki motivasi. Dalam perspektif anggota organisasi, pemahaman akan motivasi merupakan bagian yang penting dalam konteks komunikasi organisasi.Penelitian ini dilakukan dengan menggunakan metode Deskriptif Kualitatif yang bertujuan untuk mendeskripsikan motivasi member untuk terlibat menjadi anggota klub mobil Ertiga Club Indonesia di Tangerang atau Rangers. Sehingga, dapat diketahui seperti apa motivasi anggota Rangers terlibat di organisasi tersebut. Pada akhirnya, diketahui bahwa anggota Rangers terlibat di dalam organisasi tersebut termotivasi oleh kebutuhan yang ingin dipenuhinya yang tidak hanya sekedar sebagai wadah pemilik kendaraan Suzuki Ertiga di Tangerang.
The Non Performed Financing Effect on Financing and Control Strategy and Handling of Sharia Commercial Banks
Authors: Halim Sofyan , Buana Mohamad Torik Langlang 
Published: February 2022

Problematic financing or often referred to as Non-Performed Financing is financing that has difficulty paying off, either due to lack of accuracy in the analysis of lending or due to economic conditions that experience instability which results in failure in most economic activities. The research conducted is examining the problematic financing whether it influences the decision-making of financing with various Islamic contracts, namely the mudharabah, musyarakah, Murabaha, salam, istishna, Ijarah, Qard, and Hiwalah agreements and examines the strategies carried out by the Shari'ah Commercial Bank to do handling the problematic financing.The study was conducted with quantitative and descriptive methods, with the results of the study that NPF In Mudharabah, Murabahah, and ijarah contract financing there is a positive relationship between the two variables, so it can be concluded that the increase in NPF does not affect the fund distribution policy with mudharabah agreements, because The contract positively increases, while the NPF for financing with Musyarakah, Istishna and qardh contracts has a negative relationship so it can be concluded that the NPF in financing with the Musharaka contract has a negative effect in the sense that the Shari'ah Commercial Bank in general distributing financing to customers is limited due NPF by paying attention to redline facilities, BUS only provides financing facilities for businesses that contain minimal risks. NPF in general, Sharia Commercial Banks do not really influence policies in financing distribution to customers with various financing agreements. The results of the regression determination analysis show that the percentage effect of NPF on financing distribution policies with mudharabah, musyarakah, Murabaha, Murabaha, istishna, ijarah, and qardh contracts in Islamic Commercial Banks is 33.8%, while the remaining 66.2% is influenced by variables others not formulated in this research model. The Normality Test results show that the NPF and Musyarakah contract financing is normally distributed while the Mudharabah, Murabahah, Istishna, Ijarah and Qardh variables are not normally distributed because the significance is lacking.The Sharia Commercial Bank in dealing with Non-Performed Financing issues generally refers to the MUI Sharia Board Fatwa, Bank Indonesia Regulations, and OJK Regulations, which are with rescheduling, reconditioning, restructuring and Write Off. This research is expected to be useful for stakeholders related to this research and for future researchers to be able to improve further research.
Cybersecurity Research in Accounting Information Systems: A Review and Framework
Authors: Cram W. Alec , Wang Tawei , Yuan Jonathan 
Published: February 2022

ABSTRACT
The study of cybersecurity issues plays a fundamental role in accounting information systems (AIS) research. However, as the importance of cybersecurity has continued to grow in other disciplines, such as computer science and management information systems, it has become less clear what is distinct about AIS-based cybersecurity research, what unique insights AIS research has contributed to the study of cybersecurity, and what promising directions for AIS research into cybersecurity remain untapped. In order to answer these questions, we perform a literature review covering 56 articles published in 11 AIS-oriented journals. We find four distinct, yet related, categories of research inquiry: cybersecurity risks and threats, cybersecurity controls, cybersecurity-related assurance, and cybersecurity breaches. In highlighting the key insights uncovered from these four areas, we frame “what we know,” as well as “what remains to be learned,” by outlining a detailed proposal of future research opportunities for AIS researchers.
An Evaluation of SEC 10-K Charts
Authors: Garrett Nathan 
Published: February 2022

ABSTRACT
This project measured the effectiveness of charts in SEC 10-K filings. Amazon Mechanical Turk workers and business students participated in the online experiment. The first half of the study asked participants to interpret five charts rarely found in 10-K filings, including combo charts, scatterplots, stacked bars, relative waterfall charts, and absolute waterfall charts. While participants were successful with combo charts, stacked bars, and absolute waterfalls, half were unable to interpret a scatterplot, and only a handful understood relative waterfalls. The second half of the experiment tested the effects of the three most common design flaws found in 10-K charts. Users were influenced by each of the three flaws: line charts using a non-zero vertical axis, bar charts using an unlabeled non-zero vertical axis, and pie charts using a 3-D perspective. Accounting students should be better trained in deceptive chart designs, and companies should improve their 10-K charts.
A Positive Theory of Accounting-Based Management by Exception
Authors: Penno Mark C. 
Published: February 2022

ABSTRACT
Under the widespread planning-and-control paradigm, organizations schedule their budgeting early in the period (planning) when the organization has more time to carefully reflect on the processes to be later controlled. I refer to a budgeting process that conveys thresholds to managers as management by exception (MBE), and model MBE as a limited communication device, which alleviates the manager's burden of retrieving the details from the planning phase while preserving enough information to maintain effective control. Accordingly, I identify a threshold-based MBE algorithm, which is shown to approximate the performance of a full-communication policy, suggesting that simple static threshold-based communication can be effective. The equivalence between a full-disclosure policy and perfectly flexible budgets helps to explain the popularity of static budgets in light of these findings. The results also challenge the accounting concept of materiality by suggesting that less important activities may actually have tighter thresholds.
JEL Classifications: D21; M41.
Home Use of Mini-Dose Glucagon As a Novel Treatment for Hypoglycemia Following Repeated, Prolonged Fasts in Type 1 Diabetes During Ramadan
Authors: Algeffari Metab , Hussain Sufyan , Almogbel Turki , Alsharidah Mansour , Alghadouni Habibah , Mahmood Farid 
Published: February 2022

OBJECTIVE
We determined the efficacy of self-administered subcutaneous mini-dose glucagon (MDG) to treat fasting-induced hypoglycemia in type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
This was a 4-week randomized, controlled crossover trial of 2-week MDG or 2-week oral glucose tablets (OG, control) involving 17 adults with T1D during Ramadan.

RESULTS
Compared with OG, MDG demonstrated a significant higher change in blood glucose from baseline to 30 min (Δt30, P &lt; 0.001) and 1 h (Δt60, P = 0.02). The efficacy of MDG was preserved following ≥8 h fasting with significantly higher Δt30 in MDG (P = 0.01). Over the entire 2 weeks, MDG period had increased time in 70–180 mg/dL (P = 0.009) and less time &lt;70 mg/dL (P = 0.04). MDG use resulted in higher completion of fasts compared with OG (P &lt; 0.001).

CONCLUSIONS
MDG administration is an effective alternative to OG for prevention and treatment of fasting-induced hypoglycemia, offering improved glycemic control and promoting successful completion of prolonged fasts.