bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does endovascular duration impact clinical outcomes in aortic arch repair? The RELAY™ branched international stance
Authors: Tan Sven Z. C. P. , Surkhi Abedalaziz O. , Jubouri Matti , Bailey Damian M. , Williams Ian M. , Bashir Mohamad 
Published: July 2022

BackgroundThe high mortality and morbidity rates in surgical aortic arch repair are a barrier to therapy for a considerable proportion of patients with aortic arch aneurysm or dissection. There is hence a demand for the development and adoption of a minimally invasive alternative to aortic arch repair, such as thoracic endovascular aortic repair (TEVAR). Procedural duration is a key factor in the pathogenesis of complications in surgical aortic arch repair. Herein, we evaluate whether endovascular duration impacts neurological outcomes, target vessel patency, and reintervention rates in aortic arch TEVAR with RELAY™ Branched (Terumo Aortic, Inchinnan, UK), which is specifically developed for on-label use within the aortic arch.MethodsProspective data was collected between January 2019 and January 2022 on the clinical outcomes of TEVAR for aortic arch dissection and aneurysm with RELAY™ single-, double-, and triple branched endoprostheses from centers across Europe. They were then retrospectively analyzed with descriptive and distributive analysis. Follow-up data on the incidence of disabling stroke (DS), target vessel patency, and reintervention from 30 days and 6-, 12-, and 24 months postoperative was included in the analysis.Results147 (99.3%) of all 148 cases were successful. Over the 24 month follow-up period, in total 6 (4.1%) patients suffered DS, 24 (16.3%) required reintervention, and target vessel patency was exhibited in 118 (80.2%) patients. The modal endovascular duration was 100–150 min (in 64.6%, n = 95 cases). Analysis revealed that endovascular duration was associated with a lower likelihood of reintervention at 30 days, 6-, and 12 months (P = 0.011, P = 0.019, P = 0.037), a greater likelihood of target vessel patency at 6- and 24 months (P = 0.032, P = 0.035). No relationship between endovascular duration and DS was revealed.DiscussionThe data demonstrates that RELAY™ Branched is associated with promising clinical outcomes for on-label aortic arch TEVAR. The underlying mechanism linking endovascular duration and reintervention rates, or target vessel patency is likely multifactorial and complex. Given that TEVAR is carried out under general anesthetic only, it is unlikely that prolonged procedural duration has any major effect over neurological outcomes for arch TEVAR.
A record of Holocene climate changes in central Asia derived from diatom-inferred water-level variations in Lake Kalakuli (Eastern Pamirs, western China)
Authors: Peng Yumei , Rioual Patrick , Jin Zhangdong 
Published: July 2022

The unique geographical and climatic settings of the eastern Pamirs make this region sensitive to the Westerlies and global climate change. Holocene fluctuations in water-level of Lake Kalakuli, a proglacial lake located to the northwest of the Muztag Ata glacier, were reconstructed based on diatoms from a ∼15 m long sediment core spanning the last ∼9,900 years. To establish how diatom species distribute in relation to water depth in Lake Kalakuli, a dataset of 45 surface sediment samples was retrieved from different water depth. Statistical analyses such as cluster analysis (TWINSPAN) and redundancy analysis (RDA) were used to demonstrate that the water depth gradient is the main environmental gradient driving the distribution of these diatom assemblages. A diatom-water depth transfer function, was then developed using a weighted averaging partial least squares component 2 model (R2 = 0.89, RMSEP = 1.85 m) and applied to the Holocene diatom sequence from Lake Kalakuli. Due to the large residual errors in the model only the general trends in water level are proposed. Effective moisture increased rapidly during the early Holocene, as the water depth reached a high level from the lowest level within about two thousand years. Only small amplitude fluctuations were recorded during the mid- and late Holocene until the last few hundred years when a marked increase occurred. Changes in summer insolation over the northern hemisphere drove the advances and retreats of the Muztag Ata glacier, which in turn controlled the fluctuations of water level in this lake. The diatom-derived paleoclimatic trend from Lake Kalakuli is consistent with the Holocene climate evolution in the Westerlies-dominated area of Central Asia.
Education Equality and Its Influencing Factors for Migrant Children in the Compulsory Education Stage Based on Multi-Source Data: A Case Study of Dalian, China
Authors: Zhang Zhenchao , Luan Weixin , Tian Chuang , Su Min , Li Zeyang 
Published: July 2022

Inequality in the admission of migrant children is an important manifestation of inequities at the compulsory education stage in China. Spatial differences in the allocation of educational resources and the factors affecting the number of enrolled migrant children led to the following conclusions: 1) the total number of migrant children in Dalian is growing situationally, with a total increase of 29,223 from 2008 to 2020. 2) The migrant children in Dalian in 2020 are distributed in a spatially uneven manner, with most of them concentrated in the periphery of the Ganjingzi District, south of the Jinzhou area (suburban areas), where very few of them were enrolled in high-quality junior high and primary schools. 3) The distribution of educational resources differed significantly between the central urban areas and suburban areas. 4) The internal factor of schools constraining the admission of migrant children is the teacher–student ratio. For every 1% increase in the teacher–student ratio, the number of migrant children decreases by 4.12%. The main external factors affecting the admission of migrant children were rental prices and the area occupied by construction, which increased by 1% for each 2,000 m buffer range of school and 0.25% for the number of migrant children and decreased by 0.29% for each 2,000 m buffer range of the school.
Association Between Maternal Weight Gain in Different Periods of Pregnancy and the Risk of Venous Thromboembolism: A Retrospective Case–Control Study
Authors: Wu Yuelin , Pei Jindan , Dong Lingling , Zhou Zheying , Zhou Tianfan , Zhao Xiaobo , Che Ronghua , Han Zhimin , Hua Xiaolin 
Published: July 2022

BackgroundVenous thromboembolism (VTE) remains an important cause of maternal deaths. Little is known about the associations of specific periods of gestational weight gain (GWG) with the category of VTE, pulmonary embolism (PE), or deep venous thrombosis (DVT) with or without PE.MethodsIn a retrospective case–control study conducted in Shanghai First Maternity and Infant Hospital from January 1, 2017 to September 30, 2021, cases of VTE within pregnancy or the first 6 postnatal weeks were identified. Controls without VTE were randomly selected from women giving birth on the same day as the cases, with 10 controls matched to each case. Total GWG and rates of early, mid, and late GWG values were standardized into z-scores, stratified by pre-pregnant body mass index (BMI). The adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated through multivariate logistic regression models.ResultsThere were 196 cases (14.4 per 10,000) of VTE within pregnancy or the first 6 postnatal weeks were identified. Higher total weight gain was associated with increased risks of PE (aOR, 13.22; 95% CI, 2.03–85.99) and VTE (OR, 10.49; 95% CI, 1.82–60.45) among women with underweight. In addition, higher total weight gain was associated with increased risk of PE (aOR, 2.06; 95% CI, 1.14–3.72) among women with healthy weight. Similarly, rate of higher early weight gain was associated with significantly increased risk for PE (aOR, 2.15; 95% CI, 1.05–4.42) among women with healthy BMI. The lower rate of late weight gain was associated with increased risks of PE (aOR, 7.30; 95% CI, 1.14–46.55) and VTE (OR, 7.54; 95% CI, 1.20–47.57) among women with underweight. No significant associations between maternal rate of mid GWG and increased risk for any category of VTE, PE, or DVT with or without PE were present, regardless of maternal pre-pregnant BMI.ConclusionThe GWG associations with the category of VTE, PE, or DVT with or without PE differ at different periods of pregnancy. In order to effectively improve maternal and child outcomes, intensive weight management that continues through pregnancy may be indispensable.
Pretracheal Lymph Node Subdivision in Predicting Contralateral Central Lymph Node Metastasis for Unilateral Papillary Thyroid Carcinoma: Preliminary Results
Authors: Chen Qiang , Liu Yang , Lu Wei , Zhang Lingyun , Su Anping , Liu Feng , Zhu Jingqiang 
Published: July 2022

BackgroundThe aims of this study were to assess the clinical value of pretracheal lymph node subdivision in identifying patients with contralateral central lymph node metastasis (CLNM) and risk factors for occult contralateral CLNM in unilateral PTC.MethodsA total of 139 unilateral PTC patients with a clinically node-negative neck (cN0) who underwent bilateral central neck dissection (CND) were prospectively enrolled. Intraoperatively, the pretracheal region was further divided into ipsilateral and contralateral subregions. Ipsilateral and contralateral pretracheal lymph nodes (LNs) as well as other CLNs (prelaryngeal, ipsilateral paratracheal and contralateral paratracheal) were labeled separately and sent for pathological examination. Demographic and clinicopathologic variables were analyzed to identify factors predictive of contralateral CLNM.ResultsOf 139 patients, bilateral CLNM was present in 37 (26.6%) patients. Contralateral pretracheal LNM was significantly associated with contralateral CLNM. In multivariate analysis, prelaryngeal LNM (P = 0.004, odds ratio = 3.457) and contralateral pretracheal LNM (P = 0.006, odds ratio = 3.362) were identified as risk factors for contralateral CLNM. Neither neck recurrence nor distant metastasis was observed within the mean follow-up duration of 9.1 ± 1.8 months.ConclusionsIn most unilateral cN0 PTCs, performing ipsilateral CND is appropriate, while patients presenting with evident nodal disease intraoperatively or preoperatively in the contralateral central neck should undergo bilateral CND. Intraoperative re-evaluation of prelaryngeal and contralateral pretracheal LNs may be helpful in determining the extent of CND.
Fitness Culture and Green Space Equity: Accessibility Evaluation of Shanghai Communities
Authors: Qiu Tingting , Zhou Daliang , Li Wen 
Published: July 2022

In China, sports parks, and green spaces are often spatially integrated to realize the multiple functions of shared green spaces and play an important role in the production and living services of its residents. In this article, it is collectively referred to as green sport space (GSS). Whether the distribution of GSS is equal has an important impact on the sustainable lifestyle and the rehabilitation under the pandemic. Based on the POI data of the Shanghai urban area, it is preliminarily found that the areas with extremely high and high production and living densities are mainly distributed in downtown Shanghai. Polarization of the GSS distribution area and the high heat of points of interest can be seen. When the service radius of the GSS in Shanghai is 500, 750, and 1,000 m, the green space ecological service area can reach 2089.08, 3164.62, and 4469.75 km2, covering 26.17, 39.64, and 55.99% of the total area, respectively. The coverage for walking accessibility of GSSs in Shanghai is extremely uneven. Based on network analysis, the overall accessibility of GSS under the walking mode in each residential district fails to meet the standard of a 15-min living circle, with an average of 15.37 min. The evaluation results of this plan demonstrate that Shanghai needs to further provide GSS space for the public in future to improve public wellbeing and diversify sports spaces.
Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer
Authors: Lei Tianxiang , Zhang Yongxin , Wang Xiaofeng , Liu Wenwei , Feng Wei , Song Wu 
Published: July 2022

BackgroundExosome circRNAs (Exo-circRNAs) regulate cancer progression and intercellular crosstalk in the tumor microenvironment. However, their biological functions and potential clinical importance in colorectal cancer (CRC) remain unknown.MethodsWe used exoRBase 2.0 data to identify significant differentially expressed Exo-circRNAs (Exo-DEcircRNAs) in CRC patients and healthy individuals. The least absolute shrinkage and selector operation algorithm, support vector machine-recursive feature elimination, and multivariate Cox regression analyses were used to select candidate Exo-circRNAs and constructed a diagnostic model. Quantitative reverse transcription-polymerase chain reaction analysis was performed to confirm the expression of Exo-circRNAs in the serum samples of patients. Furthermore, we constructed an exosome circRNA-miRNA-mRNA network for CRC. Upregulated target mRNAs in the exosome competing endogenous RNA (Exo-ceRNA) network were used for functional and pathway enrichment analyses. We identified 22 immune cell types in CRC patients using CIBERSORT. Correlation analysis revealed the relationship between Exo-ceRNA networks and immune-infiltrating cells. The relationship between target mRNAs and immunotherapeutic response was also explored. Finally, using the Kaplan–Meier survival curve, a prognostic upregulated target mRNA was screened. We constructed a survival-related Exo-ceRNA subnetwork and explored the correlation between the Exo-ceRNA subnetwork and immune-infiltrating cells.ResultsThe constructed diagnostic model had a high area under the curve (AUC) value in both the training and validation sets (AUC = 0.744 and AUC = 0.741, respectively). qRT-PCR confirmed that the Exo-circRNAs were differentially expressed in CRC serum samples. We constructed Exo-ceRNA networks based on the interactions among seven upregulated Exo-DEcircRNAs, eight differentially expressed miRNAs, and twenty-two differentially expressed mRNAs in CRC. Functional enrichment analysis revealed that the upregulated target mRNAs were significantly enriched in cytoskeletal motor activity and the PI3K-Akt signaling pathway. Co-expression analysis showed a significant correlation between the Exo-ceRNA networks and immune cells. The significant correlation was observed between target mRNAs and the immunotherapeutic response. Additionally, based on the prognostic upregulated target gene (RGS2), we constructed a survival-related Exo-ceRNA subnetwork (Exosome hsa_circ_0050334-hsa_miR_182_5p-RGS2). CIBERSORT results revealed that the Exo-ceRNA subnetwork correlated with M2 macrophages (P = 4.6e-07, R = 0.31).ConclusionsOur study identified an Exo-diagnostic model, established Exo-ceRNA networks, and explored the correlation between Exo-ceRNA networks and immune cell infiltration in CRC. These findings elucidated the biological functions of Exo-circRNAs and their potential clinical implications.
Compound Effects of Flood Drivers, Sea Level Rise, and Dredging Protocols on Vessel Navigability and Wetland Inundation Dynamics
Authors: Muñoz David F. , Moftakhari Hamed , Kumar Mukesh , Moradkhani Hamid 
Published: July 2022

Maritime transportation is crucial to national economic development as it offers a low-cost, safe, and efficient alternative for movement of freight compared to its land or air counterparts. River and channel dredging protocols are often adopted in many ports and harbors of the world to meet the increasing demand for freight and ensure safe passage of larger vessels. However, such protocols may have unintended adverse consequences on flood risks and functioning of coastal ecosystems and thereby compromising the valuable services they provide to society and the environment. This study analyzes the compound effects of dredging protocols under a range of terrestrial and coastal flood drivers, including the effects of sea level rise (SLR) on compound flood risk, vessel navigability, and coastal wetland inundation dynamics in Mobile Bay (MB), Alabama. We develop a set of hydrodynamic simulation scenarios for a range of river flow and coastal water level regimes, SLR projections, and dredging protocols designed by the U.S. Army Corps of Engineers. We show that channel dredging helps increase bottom (‘underkeel’) clearances by a factor of 3.33 under current mean sea level and from 4.20 to 4.60 under SLR projections. We find that both low and high water surface elevations (WSEs) could be detrimental, with low WSE (&lt; -1.22 m) hindering safe navigation whereas high WSE (&gt; 0.87 m) triggering minor to major flooding in the surrounding urban and wetland areas. Likewise, we identify complex inundation patterns emerging from nonlinear interactions of SLR, flood drivers, and dredging protocols, and additionally estimate probability density functions (PDFs) of wetland inundation. We show that changes in mean sea level due to SLR diminish any effects of channel dredging on wetland inundation dynamics and shift the PDFs beyond pre-established thresholds for moderate and major flooding. In light of our results, we recommend the need for integrated analyses that account for compound effects on vessel navigation and wetland inundation, and provide insights into environmental-friendly solutions for increasing cargo transportation.
Transcriptional Down-Regulation of Major Histocompatibility Complex as a Possible Pathogenesis for Meniere's Disease
Authors: Choi Kwang-Dong , Oh Eun Hye , Kim Hyun Sung , Kim Hyang-Sook , Park Ji-Yun , Choi Seo Young , Choi Jae-Hwan 
Published: July 2022

ObjectivesThis study aimed to determine the underlying pathogenesis of Meniere's disease (MD) using transcriptome analysis.MethodsTotal RNA was extracted from the peripheral blood mononuclear cells of 39 patients with MD and 39 controls. Through microarray analysis for nine patients and controls, the differentially expressed genes (DEGs) of those two groups were screened based on cut-off criteria (|fold changes| &gt; 2.0 and adjusted p-value &lt; 0.05). The functional enrichment analysis of DEGs was performed using Gene Ontology (GO).ResultsThere were 996 DEGs identified in the MD group: 415 were upregulated and 581 were downregulated. A functional enrichment analysis indicated that the downregulated DEGs were significantly enriched in terms related to immune system processes. Among them, 17 genes were enriched in terms for the major histocompatibility complex (MHC) protein complex, and the relative messenger RNA (mRNA) levels of three markedly downregulated DEGs [fold changes &lt; −5: human leukocyte antigen (HLA)-DMA, HLA-DRB1, and HLA-DPB1] were significantly decreased in another 30 patients with MD compared with normal controls by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). However, there were no correlations between the expression levels of these three genes and clinical data, such as age, onset age, time course, or hearing threshold.ConclusionsOur transcriptome analysis showed that the downregulated DEGs in MD were mainly associated with the immune system pathways including the MHC protein complex in MD. Remarkably, a breakdown in immunological tolerance mediated by MHC class II may contribute to the MD development, which has implications for targeted treatment.
Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology
Authors: Buchheim Anna , Ziegenhain Ute , Kindler Heinz , Waller Christiane , Gündel Harald , Karabatsiakis Alexander , Fegert Jörg 
Published: July 2022

IntroductionChildhood maltreatment (CM) is a developmental risk factor and can negatively influence later psychological functioning, health, and development in the next generation. A comprehensive understanding of the biopsychosocial underpinnings of CM transmission would allow to identify protective factors that could disrupt the intergenerational CM risk cycle. This study examined the consequences of maternal CM and the effects of psychosocial and biological resilience factors on child attachment and stress-regulatory development using a prospective trans-disciplinary approach.MethodsMother-child dyads (N = 158) participated shortly after parturition (t0), after 3 months (t1), and 12 months later (t2). Mothers’ CM experiences were assessed at t0, attachment representation at t1 and psychosocial risk and social support were assessed at t1 and t2. At t2, dyads participated in the Strange Situation Procedure (SSP). Children’s attachmen status were classified as organized vs. disorganized, including their level of disorganized behavior, and heart rate (HR) and respiratory sinus arrhythmia (RSA) were recorded as stress response measures of the autonomic nervous system. Maternal caregiving during SSP was assessed using the AMBIANCE scale. Child’s single nucleotide polymorphisms rs2254298 within the oxytocin receptor (OXTR) and rs2740210 of the oxytocin gene (OXT) were genotyped using DNA isolated from cord blood.ResultsMaternal CM experiences (CM+) were significantly associated with an unresolved attachment status, higher perceived stress and more psychological symptoms. These negative effects of CM were attenuated by social support. As expected, maternal unresolved attachment and child disorganized attachment were significantly associated. Maternal caregiving did not mediate the relationship between maternal and child attachment but influenced children’s HR and RSA response and disorganized behavior. Moreover, the rs2254298 genotype of the OXTR gene moderated the stress response of children from mothers with CM. Children carrying the rs2740210 risk allele of the OXT gene showed more disorganized behavior independent from maternal CM experiences.ConclusionWe replicated and extended existing CM and attachment models by co-examining maternal attachment, social support, and child genetic susceptibility on child attachment and cardiovascular stress regulation. The findings contribute to an extended understanding of risk and resilience factors and enable professionals to target adequate services to parents and children at risk.
Interaction Analysis Based on Shapley Values and Extreme Gradient Boosting: A Realistic Simulation and Application to a Large Epidemiological Prospective Study
Authors: Orsini Nicola , Moore Alex , Wolk Alicja 
Published: July 2022

BackgroundSHapley Additive exPlanations (SHAP) based on tree-based machine learning methods have been proposed to interpret interactions between exposures in observational studies, but their performance in realistic simulations is seldom evaluated.MethodsData from population-based cohorts in Sweden of 47,770 men and women with complete baseline information on diet and lifestyles were used to inform a realistic simulation in 3 scenarios of small (ORM = 0.75 vs. ORW = 0.70), moderate (ORM = 0.75 vs. ORW = 0.65), and large (ORM = 0.75 vs. ORW = 0.60) discrepancies in the adjusted mortality odds ratios conferred by a healthy diet among men and among women. Estimates were obtained with logistic regression (L-ORM; L-ORW) and derived from SHAP values (S-ORM; S-ORW).ResultsThe sensitivities of detecting small, moderate, and large discrepancies were 28, 83, and 100%, respectively. The sensitivities of a positive sign (L-ORW &gt; L-ORM) in the 3 scenarios were 93, 100, and 100%, respectively. Similarly, the sensitivities of a positive discrepancy based on SHAP values (S-ORW &gt; S-ORM) were 86, 99, and 100%, respectively.ConclusionsIn a realistic simulation study, the ability of the SHAP values to detect an interaction effect was proportional to its magnitude. In contrast, the ability to identify the sign or direction of such interaction effect was very high in all the simulated scenarios.