bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Daprodustat Vs rhEPO for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis and Trial Sequential Analysis
Authors: Fu Zhangning , Geng Xiaodong , Chi Kun , Song Chengcheng , Wu Di , Liu Chao , Hong Quan 
Published: March 2022

Introduction: Daprodustat, a novel hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI), its efficacy and safety remain unclear. Thus, we conducted this meta-analysis aiming at investigating its efficacy and safety on the treatment of patients with chronic kidney disease (CKD)-related anemia.Methods: We systematically searched for relevant studies in PubMed, Embase, Cochrane Library and Clinical Trial Registries databases from inception until December 2021. We selected randomized controlled trials comparing daprodustat with recombinant human erythropoietin (rhEPO) in anemia patients with CKD with or without dialysis.Results: Seven studies including 7933 patients met the inclusion criteria. For both nondialysis-dependent (NDD-) CKD and dialysis-dependent (DD-) CKD patients, the pooled results showed that there was no significant difference in the changes in hemoglobin levels between the daprodustat and rhEPO groups (mean difference (MD) = −0.01, 95% confidence interval (CI) = −0.38, 0.35, p = 0.95; MD = 0.15, 95% CI = −0.29, 0.60, p = 0.50; respectively). In addition, a significant increase in transferrin saturation (TSAT), total iron binding capacity (TIBC) and total iron was observed in daprodustat groups compared with rhEPO groups in DD-CKD patients (p &lt; 0.05). As for safety, the overall frequency of adverse events was similar between the daprodustat and rhEPO groups in DD-CKD patients (relative risk (RR) = 0.99, 95%CI = 0.92, 1.06, p = 0.76), and the trial sequential analysis (TSA) confirmed this result. But for NDD-CKD patients, the incidence of adverse events in the daprodustat groups was significantly higher than that of rhEPO groups (RR = 1.04, 95%CI = 1.01,1.07, p = 0.02), while the TSA corrected this result. No trend of increasing incidence of serious adverse events was found in all daprodustat treated patients, but the TSA could not confirm this result.Conclusion: Although daprodustat was noninferior to rhEPO in correcting anemia in both NDD-CKD and DD-CKD patients, it seemed to have a better effect on optimizing iron metabolism in DD-CKD patients. Daprodustat may be a promising alternative for the treatment of anemia in patients with CKD. However, due to the lack of included studies, future researches are needed to further evaluate the therapeutic effect of daprodustat.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42021229636.
Hypericum lanceolatum Lam. Medicinal Plant: Potential Toxicity and Therapeutic Effects Based on a Zebrafish Model
Authors: Gence Laura , Fernezelian Danielle , Bringart Matthieu , Veeren Bryan , Christophe Armelle , Brion François , Meilhac Olivier , Bascands Jean-Loup , Diotel Nicolas 
Published: March 2022

Hypericum lanceolatum Lam. (H. lanceolatum) is a traditional medicinal plant from Reunion Island used for its pleiotropic effects mainly related to its antioxidant activity. The present work aimed to 1) determine the potential toxicity of the plant aqueous extract in vivo and 2) investigate its putative biological properties using several zebrafish models of oxidative stress, regeneration, estrogenicity, neurogenesis and metabolic disorders. First, we characterized the polyphenolic composition by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and identified chlorogenic acid isomers, quercetin and kaempferol derivatives as the major compounds. We then evaluated for the first time the toxicity of an aqueous extract of H. lanceolatum and determined a maximum non-toxic concentration (MNTC) in zebrafish eleutheroembryos from 0 to 96 hpf following OECD (Organization for Economic Cooperation and Development) guidelines. This MNTC test was also determined on hatched eleutheroembryos after 2 days of treatment (from 3 to 5 dpf). In our study, the anti-estrogenic effects of H. lanceolatum are supported by the data from the EASZY assay. In a tail amputation model, we showed that H. lanceolatum at its MNTC displays antioxidant properties, favors immune cell recruitment and tissue regeneration. Our results also highlighted its beneficial effects in metabolic disorders. Indeed, H. lanceolatum efficiently reduces lipid accumulation and body mass index in overfed larva- and adult-models, respectively. In addition, we show that H. lanceolatum did not improve fasting blood glucose levels in a hyperglycemic zebrafish model but surprisingly inhibited neurogenesis impairment observed in diabetic conditions. In conclusion, our study highlights the antioxidant, pro-regenerative, anti-lipid accumulation and pro-neurogenic effects of H. lanceolatum in vivo and supports the use of this traditional medicinal plant as a potential alternative in the prevention and/or treatment of metabolic disorders.
Comparing Revision Total Knee Arthroplasty Stems at a High-Volume Revision Center
Authors: Kemker Bernard P. , Sowers Christopher B. , Seedat Raees , Satpathy Jibanananda , Patel Nirav K. , Lombardo Daniel J. , Golladay Gregory J. 
Published: March 2022

IntroductionHybrid fixation and fully cemented fixation are commonly used in revision total knee arthroplasty (rTKA). These two techniques are typically done based on surgeon preference and one has not demonstrated superiority over the other. The purpose of this study was to examine if there was a difference in survivorship between the two different techniques.MethodsA retrospective cohort study of all consecutive patients undergoing rTKA (CPT 27487) from January 1, 2011 to January 1, 2018 at a single academic center was performed. Patients were divided into cemented and hybrid rTKA groups with comparison of patient demographic, clinical and radiological outcomes, reoperation, change in post-operative hemoglobin (HgB), and length of stay (LOS).ResultsA total of 133 rTKA for 122 patients were identified: 30.1% in the cemented and 69.9% in the hybrid groups. There was no significant difference in age (p = 0.491), sex (p = 0.250), laterality (p = 0.421), or body mass index (BMI) (p = 0.609) between the two groups. Mean LOS (hybrid 4.13 days, cemented 3.65 days; p = 0.356) and change in Hgb (hybrid 2.95 mg/dL, cemented 2.62mg/dL; p = 0.181) were not statistically different between the groups. Mean follow up for the hybrid (25.4 months, range 2–114 months) and cemented (24.6 months, range 3–75.5 months) rTKA was not statistically significant (p = 0.825). Overall survival rates were 80.9% in the hybrid and 84.6% in the cemented groups (p = 0.642).ConclusionsHybrid and fully cemented rTKA techniques have similar survival rates at a minimum followup of 2 years. Additionally, in our cohort, age, gender, and BMI were not associated with failure in either group. Furthermore, we did not observe differences in LOS or change in hemoglobin suggesting early postoperative complications may not differ between cemented and hybrid stemmed groups. Continued long-term research is required for defining the best rTKA technique.
Exploring the value of adverse life experiences of social service and support workers
Authors:   , Mackinnon Fiona 
Published: March 2022

Social services provide support to benefit the community, collectively they are an intrinsic part of our culture. Numerous international studies have suggested that persons in helping professions such as health and social services have had more adverse experiences than the general population and that these experiences may have in part formed their vocational motivation. This is an area of little research in Aotearoa that I believed worthy of exploration given that I have worked in the sector for decades and had anecdotally identified a reoccurring theme amongst my colleagues and myself of adverse life experiences contributing to our vocational motivation. The questions that guided this research inquiry were: To what extent are adverse life experiences perceived as an underlying motivator for the vocational choices of social service and support workers? To what extent are adverse life experiences perceived as contributing to advantageous attributes in social service and support workers? To what extent do social service and support workers perceive stigma and professional vulnerability exist as barriers to identifying adverse life experiences in the workplace? The study was undertaken using a convergent parallel mixed method design. Mixed methods studies are often seen in health and social care research, as both quantitative and qualitative methods are thought to have complementary strengths when undertaken simultaneously, providing deeper insight into the experiences of research participants than either approach alone. Convergent design required both quantitative and qualitative elements to be analysed independently and then interpreted together, this layered approach further supported understanding the experiences of participants. For the most part respondents commented in the first person when referring to adverse life experiences, suggesting a high incidence of adverse life experiences amongst respondents. Adverse life experiences were considered as influencing vocational choice by numerous respondents; however, it was clear barriers exist to identifying as having had adverse life experiences in the professional context due to fear of stigma and discrimination. Findings suggested there are issues relating to the collective understanding of what ‘recovery’ is that has implications for lived experience workers and those who identified as having had adverse life experiences. I have recommended that further research is indicated as a means to advance understanding and acceptance of the relationship between adverse life experiences, post traumatic growth and helping professions in the cultural context of Aotearoa and our known societal issues. The process of practitioner inquiry I believe has advanced my capacity to continue to evolve and develop and remain relevant to the sector and environments I work in. I envisage the enquiry process as having provided an enduring foundation to foster my growth and development on a continuum.
A Study on Sustainability of Corporate Social Responsibility during and Post-Covid-19
Authors: Dillip Anand M 
Published: March 2022

As part of the United Nations Development Programmes, COVID-19 provides an opportunity to rethink and enhance resilience in order to accomplish long-term development goals. The industrial sector, as well as multinational corporations, should concentrate on difficulties and challenges pertaining to the welfare of society, as well as identifying the priorities of the community, which is a necessity in a pandemic situation. Companies must concentrate their efforts on corporate social responsibility programmes that are aligned with global sustainable development goals during the emergency period of the crisis. Another element is that the ecosystem, which is defined as the community of living species, has been exploited, which has had an impact on the symbiotic interaction between them. Throughout this paper, we have looked at how industries and corporations should handle their ethical, social, legal, and economic duties, as well as how these responsibilities correspond with the Constitution and the Sustainable Development Goals.
Hereditary Motor Sensory Polyneuropathy and Optic Nerve Atrophy: Case Report
Authors: Мирзоян А.Р. , Куликова С.Л. , Лихачев С.А. , Рушкевич Ю.Н. , Забродец Г.В. , Мальгина Е.В. , Голец Ю.Н. 
Published: March 2022

Наследственная моторно-сенсорная полинейропатия (невральная амиотрофия Шарко – Мари – Тута, ШМТ) характеризуется аутосомно-доминантным, аутосомно-рецессивным и Х-сцепленным типами наследования, проявляется слабостью и мышечными атрофиями конечностей, снижением глубоких рефлексов, а также умеренными сенсорными нарушениями. Помимо явлений полинейропатии могут наблюдаться такие симптомы, как атрофия зрительных нервов, пигментный ретинит, глухота, атаксия, гломерулопатия, спастичность и т. д. В настоящее время не существует единой классификации заболевания, в связи с генетической гетерогенностью и клиническими особенностями каждого из типов ШМТ. В статье представлен клинический случай пациента 8 лет с ШМТ, у которого помимо прогрессирующей полинейропатии наблюдалась атрофия зрительных нервов. Причиной заболевания явилась гетерозиготная мутация в 7-м экзоне гена MFN2 (chr1:12059066G>A, rs879253777). При описании случая авторами сделан акцент на сложность дифференциальной диагностики описанного случая с хронической воспалительной демиелинизирующей полинейропатией, так как заболевание дебютировало после вирусной инфекции, отмечалось накопление контраста корешками спинного мозга по данным МРТ, имелась частичная положительная динамика в виде нарастания мышечной силы и улучшения зрения на фоне терапии кортикостероидами.
Hereditary motor sensory neuropathy (Charcot–Marie–Tooth neuropathy, CMT) is characterized by autosomal dominant, autosomal recessive, and X-linked types of inheritance, manifested by weakness and muscular atrophy of the limbs, decreased deep reflexes, and moderate sensory impairments. Additional symptoms of CMT are optic atrophy, retinitis pigmentosa, deafness, ataxia, glomerulopathy, spasticity etc. Currently, there is no single classification of CMT, because each type of CMT has got genetic heterogeneity and clinical features. The article presents a clinical case of 8-year-old patient with progressive polyneuropathy and optic nerve atrophy associated with«Неврология и нейрохирургия. Восточная Европа», 2020, том 10, № 3405Наследственная моторно-сенсорная полинейропатияи атрофия зрительных нервов: описание клинического случаяheterozygous mutation in the exon 7 of the MFN2 gene (chr1: 12059066G> A, rs879253777). The authors pointed out the difficulty of differential diagnosis of the case with chronic inflammatory demyelinating polyneuropathy, because the disease began after a viral infection, and the spinal roots accumulated the contrast on MRI. The therapy with corticosteroids gave a partial positive effect (increase of muscle strength and improvement of vision).
Use of Multiparametric MRI in Diagnostics of Clinically Significant Prostate Cancer
Authors: Кобильнык Ю.С. , Мыцик Ю.О. , Боржиевский А.Ц. , Дутка И.Ю. , Строй О.О. , Дац И.В. , Комнацька И.М. , Воробець Д.З. , Дмытрив В.Я. , Мацькевич В.Н. 
Published: March 2022

Введение. Рак предстательной железы (РПЖ) – наиболее распространенная злокачественная опухоль у мужчин.Цель. Оценить диагностическую эффективность применения мультипараметрической МРТ (мпМРТ) в выявлении клинически значимого РПЖ.Материалы и методы. В исследование вошло 26 мужчин с подозрением на РПЖ. Всем па-циентам проводилось комплексное клиническое обследование, которое включало мпМРТ. Оценка полученных изображений МРТ осуществлялась по системе PI-RADS.Результаты. Распределение пациентов в зависимости от оценки по системе PI-RADS было следующим: 1 балл – 2 (7,69%) пациента, 2 балла – 5 (19,23%) пациентов, 3 балла – 8 (30,77%)пациентов, 4 балла – 6 (23,08%) пациентов и 5 баллов – 5 (19,23%) человек. В подгруппе пациентов с оценкой 5 клинически значимый РПЖ был обнаружен в 100% случаев. В подгруппе с оценкой новообразования 4 клинически значимый РПЖ был диагностирован в 5 (83,33%) случаях, а у 1 (16,67%) пациента – клинически незначимый вариант опухоли. В подгруппе па-циентов с 3 баллами клинически значимый РПЖ был диагностирован в 4 (66,67%) случаях, у 1 (16,67%) пациента – клинически незначимый вариант новообразования и у 1 (16,67%) пациента – доброкачественная гиперплазия простаты.Выводы. Применение мпМРТ и системы PI-RADS версии 2 позволяло в 85,7% случаев выявлять клинически значимый вариант и избегать ненужных пункционных биопсий при отсутствии его лучевых признаков.
Introduction. Prostate cancer (PC) is the most common malignant tumor in men.Purpose. To evaluate the diagnostic effectiveness of multiparametric MRI (mpMRI) in detection of clinically significant PC.Materials and methods. The study included 26 men suspected of having PC. In all patients, a comprehensive clinical examination was performed, which included mpMRI. The evaluation of the received images was carried out in accordance with the PI-RADS system.Results. The distribution of patients according to the PI-RADS was the following: 1 point – 2 (7.69%) patients, 2 points – 5 (19.23%) patients, 3 points – 8 (30.77%) patients, 4 points – 6 (23.08%) patients and 5 points – 5 (19.23%) persons. In the subgroup of patients with 5 points, clinically significant PC was detected in 100% of cases. In the subgroup of patients with tumors of 4 points, clinically significant PC was diagnosed in 5 (83.33%) cases, and in 1 (16.67%) patient – clinically insignificant tumor. In the subgroup of patients with 3 points, clinically significant PC was diagnosed in 4 (66.67%) cases, 1 (16.67%) patient – clinically insignificant tumor, and in 1 (16.67%) patient – benign prostatic hyperplasia.Conclusion. The use of mpMRT and PI-RADS version 2 allowed to detect a clinically significant PC in 85.7% of cases and to avoid unnecessary puncture biopsies.
Results of Local Intraperitoneal Chemotherapy in Resectable Gastric Cancer of the Stage IIA–IIIC
Authors: Ревтович М.Ю. 
Published: March 2022

Цель исследования. Повысить эффективность радикального лечения рака желудка (РЖ) IIА–IIIC стадий путем применения локальной адъювантной интраперитонеальной химиотерапии (ИХТ).Материалы и методы. Проанализированы результаты проспективного рандомизированного исследования, включающего 157 пациентов с резектабельным раком желудка IIА–IIIC стадий (III–IV тип по Borrmann), у 67 из которых была проведена адъювантная ИХТ с применением цисплатина, депонированного на монокарбоксицеллюлозе.Результаты. Комбинация радикальной операции и локальной ИХТ позволила в сравнении с группой хирургического контроля снизить: 1) частоту прогрессирования РЖ на 23,2% (р=0,038); 2) частоту метахронной перитонеальной диссеминации на 33,1% (р<0,001); 3) 4-летнюю кумулятивную инцидентность перитонеальной диссеминации с 44,6±7,20% до 10,9±4,70% (рGray<0,001). Применение адъювантного лечения позволило увеличить показатели 4-летнейвыживаемости: 1) скорректированной с 43,9±7,6% до 67,0±7,5% (рlog-rank=0,04); 2) выживаемо-сти, свободной от диссеминации, – с 43,6±7,4% до 67,7%±7,4% (рlog-rank=0,03).Вывод. Полученные результаты подчеркивают необходимость и целесообразность применения локальной адъювантной ИХТ у пациентов, страдающих РЖ IIА–IIIC стадии, для предупреждения последующего прогрессирования опухолевого процесса, и прежде всего предотвращения развития метахронной перитонеальной диссеминации.
Purpose. To increase the effectiveness of radical treatment of the stage IIA-IIIC gastric cancer (GC) by means of administering local adjuvant peritoneal chemotherapy (IPC).Materials and methods. In the article, there are analyzed the results of prospective randomized study of 157 patients with resectable GC of the stage IIA–IIIC (types III–IV, according to the Borrmann classification); in 67 patients, there was administered the cisplatin/polymer-based adjuvant IPC.Results. The combination of radical surgery and local IPC let to reduce (1) the frequency of GC progression by 23,2% (р=0,038), (2) the frequency of peritoneal dissemination by 33,1% (р<0,001), and (3) 4-year cumulative incidence of peritoneal dissemination from 44,6±7,20% to 10,9±4,70% (рGray<0,001). As a consequence, it was possible to increase (1) 4-year adjusted survival from 43,9±7,6% to 67,0±7,5% (рlog-rank=0,04), (2) 4-year dissemination-free survival from 43,6±7,4% to67,7%±7,4% (рlog-rank=0,03).Conclusion. The study results highlight the therapeutic efficacy and the benefits of local adjuvantIPC for the stage IIA–IIIC GC patients to prevent subsequent disease recurrence, and especially the development of metachronous peritoneal metastases.
PENGARUH DANA PIHAK KETIGA DAN CAPITAL ADEQUACY RATIO TERHADAP PROSIKLIKALITAS PERBANKAN PADA PT BANK BTN KANTOR CABANG BANDUNG TIMUR PERIODE 2016-2020
Authors: Sari Novita , Jalaluddin Jalaluddin 
Published: March 2022

ABSTRAKBerdasarkan hasil penelitian, bahwa yang melatar belakangi penelitian ini adalah fluktuatif Dana Pihak Ketiga dan Capital Adequacy Ratio (CAR), sehingga menyebabkan fluktuatifnya Prosiklikalitas di bank tersebut. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh antara Dana Pihak Ketiga (DPK) Terhadap Prosiklikalitas, serta mengetahui bagaimana pengaruh Capital Adequacy Ratio (CAR) Terhadap Prosiklikalitas di PT Bank Tabungan Negara. Objek penelitian ini menggunakan metode kuantitatif Asosiatif dengan jenis data menggunakan data Sekunder berupa laporan Triwulan PT Bank Tabungan Negara pada Periode 2016-2020. Sampel yang diteliti yaitu PT Bank Tabungan Negara yang ditentukan melalui teknik Purposive Sampling. Hasil penelitian ini menunjukan bahwa Dana Pihak Ketiga (DPK) memiliki koefisien yang bertanda positif sebesar 2,18, sedangkan Capital Adequacy Ratio (CAR) bertanda negative sebesar -0,272. Selain itu, variabel Dana Pihak Ketiga (DPK) memperoleh nilai signifikan (p-value) <a 0,05, dan Dengan demikian maka dapat disimpulkan bahwa Dana Pihak Ketiga (DPK) memiliki pengaruh yang signifikan terhadap Prosiklikalitas Perbankan, sedangkan Capital Adequacy Ratio (CAR) tidak berpengaruh terhadap Prosiklikalitas. Adapun besar pengaruh seluruh variabel independen adalah sebesar 6,40%.ABSTRACTBased on the results of the study, that behind this study is the fluctuating Third Party Fund and Capital Adequacy Ratio (CAR), thus causing fluctuating procyclicality in the bank. This study aims to find out how the influence between Third Party Funds (DPK) on Prosiklikality, as well as to know how the influence of Capital Adequacy Ratio (CAR) on Procyclicality at PT Bank Tabungan Negara. The object of this study uses associative quantitative method with data type using Secondary data in the form of Quarterly report of PT Bank Tabungan Negara in the period 2016-2020. The samples studied were PT Bank Tabungan Negara which was determined through Purposive Sampling technique. The results of this study showed that Third Party Funds (DPK) have a coefficient marked positively of 2.18, while the Capital Adequacy Ratio (CAR) is negatively marked at -0.272. In addition, the variable Third Party Fund (DPK) obtains a significant value (p-value) <a 0.05, and thus it can be concluded that Third Party Funds (DPK) have a significant influence on Banking Procyclicality, while the Capital Adequacy Ratio (CAR) has no effect on Procyclicality. The influence of all independent variables is 6.40%.
Vulnerabilidad ecológica del complejo de páramos Chilí-Barragán, Colombia, a los incrementos de temperatura en un escenario de cambio climático
Authors: Moreno Ortega Cristian David , Palma Barragán Juan Diego , Trilleras Motha Jenny Maritza , Salamanca García José Alejandro 
Published: March 2022

La presente investigación tiene como finalidad evaluar la vulnerabilidad ecológica del complejo de páramos Chilí-Barragán a los incrementos de la temperatura en el escenario de cambio climático RCP 6,0 para el periodo 1981-2095. Para lo cual se deben estimar los incrementos de la temperatura del periodo 1981-2010 y 2011-2095, determinar el impacto potencial y el potencial de recuperación del complejo de páramos Chilí-Barragán.La evaluación de la vulnerabilidad ecológica se llevó a cabo con diferentes índices e indicadores, entre los que se destaca el índice de vulnerabilidad ecológica. Los métodos que se emplearon son el del proceso analítico jerárquico y opinión de expertos.En el complejo se encontró un incremento de la temperatura media de 0,79 °C (1981-2010) y de 2,12 °C (2011-2095). Un potencial de recuperación medio y un impacto potencial alto. La vulnerabilidad ecológica es en su mayor medida alta, y representa el 47,51% del área del complejo.
Hilda Sábato. Repúblicas del Nuevo Mundo: el experimento político latinoamericano del siglo XIX
Authors: Salas Aron Emiliano 
Published: March 2022

Reseña de: Hilda, Sábato, Repúblicas del Nuevo Mundo: el experimento político latinoamericano del siglo XIX,Buenos Aires, Taurus, 2021, 238 pp. ISBN: 9789877370584