bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sporulation efficiency and spore quality in a human intestinal isolate of Bacillus cereus
Authors: Vittoria Maria , Saggese Anella , Barletta Giovanni Di Gregorio , Castaldi Stefany , Isticato Rachele , Baccigalupi Loredana , Ricca Ezio 
Published: June 2022

AbstractThe Bacillus cereus group is a species complex of the Bacillus genus that includes several closely related species. Within this group, bacteria indicated as B. cereus sensu stricto (B. cereus) are the causative agent of two different types of gastrointestinal diseases associated with food poisoning. Outbreaks of this opportunistic pathogen are generally due to the resistance of its spores to heat, pH and desiccation that makes hard their complete inactivation from food products. B. cereus is commonly isolated from a variety of environments, including intestinal samples of infected and healthy people. We report the genomic and physiological characterization of MV19, a human intestinal strain closely related (ANI value of 98.81%) to the reference strain B. cereus ATCC 14579. MV19 cells were able to grow in a range of temperatures between 20 and 44°C. At the optimal temperature the sporulation process was induced very rapidly and mature spores efficiently released, however these appeared structurally and morphologically defective. At the sub-optimal growth temperature of 25°C sporulation was slow and less efficient but a high total number of fully functional spores was produced. Altogether, results reported here indicate that the reduced rapidity and efficiency of sporulation at 25°C are compensated by a high quality and quantity of released spores, suggesting the relevance of different performances at different growth conditions for the adaptation of this bacterium to diverse environmental niches.
Constructions of youth and responses to problematic authors: examining ELA teachers’ choices to select or avoid Sherman Alexie
Authors: Cook Mike P. , Boyd Ashley , Sams Brandon 
Published: June 2022

PurposeThe purpose of this study was to examine how teachers’ constructions of youth inform their text selections, particularly as they relate to a problematic author.Design/methodology/approachAs part of a larger, national study, the authors use interview data from 18 participants – 9 who still teach and 9 who no longer teach Alexie – to consider how teachers’ constructions of youth play roles in their decisions to teach or avoid complex and controversial authors and topics, specifically the work and life of Sherman Alexie in the #MeToo era.FindingsFindings suggest teachers who constructed youth through asset-based frameworks – as complex and capable – were likely to keep teaching Alexie or have conversations about the #MeToo movement. Teachers who constructed students in deficit ways, as “not ready,” harkened back to Lesko’s (2012) critique, and were more likely to either remove Alexie from the curriculum entirely or engage students in conversations about the text only, leaving Alexie’s life out of the classroom.Originality/valueBuilding on Lesko’s work on constructions of adolescence and its intersection with Petroneet al.’s youth lens and Critical Youth Studies (e.g., Petrone and Lewis, 2021), this study describes the ways in which teachers’ views of students served as rationales for their teaching decisions around whether, if or how to include the works and life of Sherman Alexie.
Financial capability and financial wellbeing of women in community-based organizations: mediating role of decision-making ability
Authors: Parvathy V.K. , Kumar Jyothi 
Published: June 2022

PurposeFinancial capability is considered to be an important concept that has drawn the attention of many world nations. While the literature suggests various studies on financial capability and financial wellbeing, focus on their combined significance has been limited. The purpose of this paper is to examine how financial capability affects the financial wellbeing of women in community-based organizations and how decision-making ability mediated this relationship.Design/methodology/approachIn total, 1,000 women who are associated with the community-based organization – Kudumbashree in the state of Kerala, India participated in the survey-based study.FindingsThe structural equation modelling results show that there exists a significant relationship between financial capability and the financial wellbeing of women in CBOs. Further, decision-making ability was identified as a significant mediator in this relationship thus establishing a partial mediation effect.Practical implicationsThe financial social workers can focus their activities on promoting financial capability and decision making aspects of women from middle/low income families to facilitate their financial wellbeing. The scope for financial socialisation and proper orientation is more for the women associated with the community based organisations. This opportunity can be made use by the government authorities and other practitioners to change their financial outlook and contribute towards the empowerment of these women from the grass root level.Originality/valueThe studies related to financial literacy and financial inclusion are available in the Indian context, but the conceptualization of financial capability is still an under-researched area in India. Hence, this study is an attempt to explain the capability-wellbeing relationship from a financial point of view in the Indian context, and further establishes its connection with the individual's decision-making ability. To strengthen the research base, the study was conducted among the women in the community-based organization who belong to middle and low-income families.
How do e-stores grow their market share?
Authors: Klepek Martin , Kvíčala Daniel 
Published: June 2022

PurposeThe purpose of this paper is to identify how fashion and cosmetics e-stores compete and grow to help e-commerce managers set the corresponding marketing strategy. It describes the relevance of customer acquisition and retention to market share as the essential performance metrics.Design/methodology/approachAn empirical generalization approach where patterns in data appearing across studies are described by a mathematical or graphical method is used. To do that, the authors observed real transactional data and the effect of how e-stores benefit from new and returning customers and gain a larger market share. The authors have analysed behavioural data from nearly 124,000 e-commerce customers in two highly popular product categories (fashion and cosmetics) in the size of 10,000,000 euros in sales or more.FindingsFashion and cosmetics e-stores with more market penetration tend to have a higher market share measured both by the number of total purchases and the number of sales in euro. In other words, market penetration is a solid predictor of market share in all circumstances. Interestingly, no significant difference in loyalty has been observed in relation to market share growth except in the situation where the market partition was excluded from the product category.Research limitations/implicationsThe businesses under study derived only from one country and only two product categories were observed. Thus, there is a potential limitation in generalizing the findings to the whole e-commerce market from a geographical and category perspective. The length of the observation period may also play a role as a longer period increases the chance of repeat buying.Practical implicationsE-commerce managers can gain long-term market share growth mainly via higher market penetration (acquisition of new customers) and should avoid misleading overfocus on loyalty tactics (retention of current customers). The study also provides important benchmarks for e-commerce businesses in the fashion and cosmetic categories.Originality/valueIn the market share growth literature, only a handful of studies focus on stores and not on products. Moreover, there is a dominance of fast-moving consumer goods categories. Surprisingly, studies analysing ever-growing e-commerce markets are scarce. Thus, this research is original because it describes, using empirical data, how brands online, at the store level and within the fashion and cosmetics category, grow their market share. It is also one of the few studies that work with real business transactional data.
Metabolites from the fungal pathogen Batrachochytrium dendrobatidis (bd) reduce Bd load in Cuban treefrog tadpoles
Authors: Nordheim Caitlin L. , Detmering Sarah E. , Civitello David J. , Johnson Pieter T. J. , Rohr Jason R. , McMahon Taegan A. 
Published: June 2022

Abstract

Batrachochytrium dendrobatidis (Bd) has been associated with massive amphibian population declines worldwide. Wildlife vaccination campaigns have proven effective for mitigating damage from other pathogens, and there is evidence that adult frogs can acquire resistance to Bd when exposed to killed Bd zoospores and the metabolites they produced.

Here, we investigated whether Cuban treefrogs tadpoles Osteopilus septentrionalis can gain protection from Bd through exposure to a prophylaxis treatment composed of killed zoospores or soluble Bd metabolites. We used a 2 × 2 factorial design, crossing the presence or absence of killed zoospores with the presence or absence of Bd metabolites. All hosts were subsequently exposed to live Bd to evaluate susceptibility.

Exposure to killed zoospores did not induce a protective response. However, tadpoles exposed to Bd metabolites had significantly lower Bd intensity and prevalence than tadpoles that were not exposed to metabolites.

The metabolites Bd produce pose no risk of Bd infection and therefore make an epidemiologically safe prophylaxis treatment, protecting tadpoles against Bd. This work provides a promising potential for protecting amphibians in the wild as a disease management strategy for controlling Bd‐associated declines.
Socio‐emotional Wealth Preservation and Alliance Success in Family Firms: The Role of Political Instability and Alliance Management Capability
Authors: Al‐Tabbaa Omar , Nasr Abdalhamed , Zahoor Nadia , De Silva Muthu 
Published: June 2022

AbstractSocio‐emotional wealth preservation (SEW‐P) can create a dilemma for family firms when seeking to establish strategic alliance: how to manage the need to establish strategic alliances aimed at obtaining complementary network‐based resources (the economic dimension) with the fear that such a move may jeopardize family control and domination (the SEW dimension). To address this dilemma (also labelled as a ‘mixed gamble’), we theorized that the concern to preserve SEW (i.e. SEW‐P) can contribute to family firms’ alliance success being dependent on the leverage of alliance management capability (AMC). We also propose that SEW‐P can act as an organizational cognitive enabler for AMC. Yet the positive association between SEW‐P and AMC will become stronger when family firms operate in a politically unstable environment. We tested these hypotheses using a unique dataset collected from 302 family firms operating in a politically unstable environment (the Libyan context), and the analysis lends support to our model and predictions. Overall, the study advances the alliance theories and family business literature by adding new insights that explain the effect of non‐financial priorities of family firms, and related contingencies, in predicting alliance success.
Patient‐ and physician‐reported satisfaction with gastroesophageal reflux disease (GERD) treatment in Chinese clinical practice
Authors: Xiao Ying Lian , Zhang Meng Yu , Tan Nian Di , Chen Song Feng , Zhuang Qian Jun , Chen Min Hu 
Published: June 2022

ObjectiveThe aim of this study was to assess the level of satisfaction with currently prescribed medications for gastroesophageal reflux disease (GERD) in patients and physicians in China.MethodsPhysicians across China were invited to complete physician surveys concerning factors affecting the prescription of medication for GERD and their satisfaction through an online questionnaire. The enrolled physicians invited the first five GERD patients who visited them on the same day to complete online patient surveys concerning the satisfaction with medications for GERD and its influencing factors.ResultsIn total, 334 physician surveys (response rate 36.82%) and 1409 patient surveys (86.07%) were analyzed. Over half (62.57%) the physicians recommended taking a proton pump inhibitor (PPI) twice daily and the majority (88.02%) recommended taking a PPI for 1 week to 3 months. Factors affecting the prescription were how much it could improve quality of life (84.73%), followed by safety, medication compliance, and efficacy. Approximately 30% of patients reported taking a PPI twice daily and 47.20% reported taking a PPI for 1 week to 3 months. Factor affecting patients’ adherence to medications was safety (64.30%), followed by medical insurance, efficacy and convenience. Approximately one‐third of physicians and patients did not report “satisfied” or “very satisfied” with medications for GERD, including 10.51% of patients and 12.87% of physicians reporting “dissatisfied” or “very dissatisfied.”ConclusionOne‐third of GERD patients and physicians were not satisfied or very satisfied with medications for GERD. Novel medications may help optimize the management of GERD.
The Psychology of Coercion Failure: How Reactance Explains Resistance to Threats
Authors: Powers Kathleen E. , Altman Dan 
Published: June 2022

AbstractWhen confronted with coercive threats, targets often stand firm rather than back down. We identify one important yet unrecognized factor that causes actors to resist threats: psychological reactance. Reactance theory explains that when someone perceives a threat to their freedom to make choices, they attempt to restore their autonomy by refusing to capitulate. The result is unwillingness to concede to coercion that extends beyond rational incentives. We test for reactance as a cause of coercion failure with two novel experiments. Each experiment pairs a coercive threat treatment with a matched “natural costs” counterpart that imposes the same choice on the target without intentional action by a coercer. Controlling for prominent alternative explanations, including costs, benefits, power, credibility, and reputation, we find that the targets of threats capitulate less frequently and more often support aggression against their opponents.
Normothermic regional perfusion in liver transplantation from donation after cardiocirculatory death: Technical, biochemical, and regulatory aspects and review of literature
Authors: Melandro Fabio , Basta Giuseppina , Torri Francesco , Biancofiore Giandomenico , Del Turco Serena , Orlando Francesco , Guarracino Fabio , Maremmani Paolo , Lazzeri Chiara , Peris Adriano , De Simone Paolo , Ghinolfi Davide 
Published: June 2022

AbstractBackgroundOrgans from donation after circulatory death (DCD) are increasingly used for liver transplantation, due to the persisting organ shortage and waiting list mortality. However, the use of DCD grafts is still limited by the inferior graft survival rate and the increased risk of primary non‐function and biliary complications when compared to brain death donors’ grafts.MethodsAbdominal normothermic regional perfusion with extracorporeal membrane oxygenation (ECMO) is an in situ preservation strategy. which may mitigate ischemia–reperfusion injuries. and has been proposed to restore blood perfusion after the determination of death thus optimizing liver function before implantation.ResultsIn this systematic review, we highlighted the clinical evidence supporting the use of normothermic regional perfusion in DCD liver underlying the pathophysiological mechanisms, and technical, logistic, and regulatory aspects.ConclusionsDespite the lack of properly designed, prospective, randomized trials, the current available data suggest beneficial effects of normothermic regional perfusion on clinical outcomes after liver transplantation.
Concentrated sodium citrate catheter lock: “The best laid schemes o’ mice an’ men…”
Authors: Ash Stephen R. 
Published: June 2022

AbstractOur laboratory's in vitro studies showed that sodium citrate at concentrations from 23% to 47% is antibacterial, and a non‐randomized clinical trial showed that its use as a lock solution in dialysis catheters greatly decreased the incidence of CRBSI. The licensee placed 30 ml bottles of 47% sodium citrate in kits containing the Ash Split Cath, with clear instructions to dilute the solution and inject only the catheter volume as a catheter lock. Gross misuse of the solution by one physician led to a serious adverse outcome. FDA instructed the company to remove the product from the market and issued a warning not to use concentrated citrate off‐label. Sodium citrate at 23%–30% is widely used in Europe, without major complications or side effects. However, our EPO patent was contested by a Dutch company and they eventually prevailed.
The hemodynamics and blood trauma in axial blood pump under different operating models
Authors: Zhang Yunpeng , Wu Xiangyu , Wang Yiming , Liu Hongtao , Liu Guang‐Mao 
Published: June 2022

AbstractBackgroundSpeed modulation of blood pumps has been proved to help restore vascular pulsatility and implemented clinically during treatment for cardiac failure. However, its effect on blood trauma has not been studied thoroughly.MethodsIn this paper, we study the flow field of an axial pump FW‐X under the modes of co‐pulse, counter pulse, and constant speed to evaluate the blood trauma. Based on the coupling model of cardiovascular systems and axial blood pump, aortic pressure and the pump flow were obtained and applied as the boundary conditions at the pump outlet and inlet. The level of shear stress and hemolysis index were derived from computational fluid dynamics (CFD) simulation.ResultsResults showed that the constant speed mode had the lowest shear stress level and hemolytic index at the expense of diminished pulsatility. Compared with the constant speed mode, the hemolysis index of co‐pulse and counter pulse mode was higher, but it was helpful to restore vascular pulsatility.ConclusionsThis method can be easily incorporated in the in vitro testing phase to analyze and decrease a pump's trauma before animal experimentation, thereby reducing the cost of blood pump development.
HERACLIS‐TAF: a multi‐centre prospective cohort study on 2‐year safety and efficacy of tenofovir alafenamide in patients with chronic hepatitis B with renal and/or bone disorders or risks
Authors: Papatheodoridis George V. , Mimidis Kostas , Manolakopoulos Spilios , Gatselis Nikolaos , Goulis John , Kapatais Andreas , Manesis Emanuel , Vasiliadis Themistoklis , Triantos Christos , Samonakis Dimitrios , Sevastianos Vasilios , Karatapanis Stelios , Elefsiniotis Ioannis , Deutsch Melanie , Mylopoulou Theodora , Papatheodoridi Margarita , Kranidioti Hariklia , Agorastou Polyxeni , Karaoulani Theofani , Kyriazidou Anastasia , Zisimopoulos Konstantinos , Dalekos George N. 
Published: June 2022

SummaryBackgroundTenofovir alafenamide (TAF) has exhibited a favourable safety profile on estimated glomerular filtration (eGFR) and bone mineral density (BMD), but has not been extensively studied in patients with renal impairment and/or BMD disorders.AimsTo assess predictors of eGFR changes and other safety and efficacy outcomes during 24‐month TAF therapy in patients with chronic hepatitis B with renal and/or BMD disorders/risks.MethodsAdult patients who started TAF at 13 clinics throughout Greece were prospectively included. Main exclusion criteria were hepatitis D, active malignancy and bisphosphonates recent use. MDRD formula was used for eGFR estimation.ResultsTAF was initiated in 176 patients (91% switched from another agent). At 12 and 24 months, HBV DNA was undetectable in 97% and 100%, and ALT was normal in 96% and 95% of patients. Median ALT decreased from baseline to month 12/24 (p < 0.001). Mean eGFR decreased from previous treatment initiation to baseline (p < 0.001), increased at 12 months and remained stable at 24 months (p ≤ 0.001). An increase in eGFR of >3 ml/min at 12 month was observed in 50% of patients and was associated mainly with baseline eGFR 30–60 ml/min. In patients with baseline phosphate <2.5 mg/dl, mean serum phosphate increased at month‐12/24 (p < 0.001). Median BMD did not change significantly from baseline to 12 months but improved at 24 months (p = 0.001).ConclusionsIn mostly switched patients with renal and/or BMD disorders/risks, eGFR improved after 12‐24 months of TAF treatment, especially in patients with baseline eGFR 30–60 ml/min. TAF may also improve low serum phosphate, BMD and ALT, whereas it maintains or induces virological suppression.
Switching to tenofovir alafenamide for nucleos(t)ide analogue‐experienced patients with chronic hepatitis B: week 144 results from a real‐world, multi‐centre cohort study
Authors: Ogawa Eiichi , Nakamuta Makoto , Koyanagi Toshimasa , Ooho Aritsune , Furusyo Norihiro , Kajiwara Eiji , Dohmen Kazufumi , Kawano Akira , Satoh Takeaki , Takahashi Kazuhiro , Azuma Koichi , Yamashita Nobuyuki , Yamashita Naoki , Sugimoto Rie , Amagase Hiromasa , Kuniyoshi Masami , Ichiki Yasunori , Morita Chie , Kato Masaki , Shimoda Shinji , Nomura Hideyuki , Hayashi Jun ,   The Kyushu University Liver Disease Study (KULDS) Group
Published: June 2022

SummaryBackgroundTenofovir alafenamide (TAF) may be preferable to other nucleos(t)ide analogues (NA) regarding outcomes against chronic hepatitis B virus (HBV) infection.AimsTo evaluate the longer term virological/biochemical effectiveness of TAF and the renal safety of sequential therapy to TAF in real‐world settingsMethodsThis multi‐centre, retrospective cohort study included consecutive adult patients who were switched from other NAs to TAF. We assessed the virological and biochemical responses up to 144 weeks. We performed sensitivity analyses for a subgroup with chronic kidney disease (CKD) at baseline.ResultsWe analysed the data of 391 patients with chronic hepatitis B previously treated with entecavir (ETV) (n = 174), tenofovir disoproxil fumarate (TDF) (n = 116) or an NA combination (n = 101) for ≥ 24 months. HBV DNA <10 IU/ml at week 144 was found for 99% of patients, regardless of prior NA regimen or HBV DNA level at baseline. For patients who switched from TDF to TAF, total, low‐density lipoprotein, high‐density lipoprotein cholesterol and triglycerides were significantly increased after the switch. Patients who switched from a nucleotide analogue to TAF had an improved estimated glomerular filtration rate, although the rate of hypophosphataemia (<2.5 mg/dl) remained 9.7% at week 144. The virological and biochemical responses of patients with CKD were similar to the overall results.ConclusionsSwitching to TAF remained effective and safe for up to 3 years. Given the increasing comorbidities related to ageing, it will be important to carefully follow the change in the lipid levels of patients with a prior TDF‐based regimen.
On the (im)possibilities of being a good enough researcher at a neoliberal university
Authors: Zielke Julia , Thompson Matthew , Hepburn Paul 
Published: June 2022

AbstractThree years after finishing a participatory research project with a low‐income community, we look back at the ways we struggled and continue to struggle under the neoliberal climate we find ourselves in. Specifically, we ask whether the managerialised research infrastructures of the neoliberal university provide a ‘good enough’ environment, and whether we, as researchers, were able to conduct ‘good enough’ research with austerity‐stricken respective communities. Engaging with literature on failure and self‐care, we offer insights on the (im)possibilities of doing ‘good enough’ research in climates that are harsh to participants as well as researchers. Taking a Winnicottian, psychoanalytic lens of working under ‘average expectable conditions’, we conclude that, over time, we may perhaps create moments of micro‐resistance that may make our failures productive; however, these should not give research institutions a free pass to continue their not‐good‐enough, exploitative practices.