bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study
Authors: Pérez-Gimeno Gloria , Seral-Cortes Miguel , Sabroso-Lasa Sergio , Esteban Luis Mariano , Lurbe Empar , Béghin Laurent , Gottrand Frederic , Meirhaeghe Aline , Muntaner Manon , Kafatos Anthony , Molnár Dénes , Leclercq Catherine , Widhalm Kurt , Kersting Mathilde , Nova Esther , Salazar-Tortosa Diego F. , Gonzalez-Gross Marcela , Breidenassel Christina , Sinningen Kathrin , De Ruyter Thaïs , Labayen Idoia , Rupérez Azahara I. , Bueno-Lozano Gloria , Moreno Luis A. 
Published: September 2022

Abstract
Background: Several single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels, in adults and children. A combination of SNPs, forming a genetic risk score (GRS) could be considered as a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the aim of our study was to build a GRS being able to predict the genetic predisposition to hypertension in European adolescents. Methods: Data were extracted from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. A total of 869 adolescents (53 % female), aged 12.5-17.5, with complete genetic and BP information were included. The sample was divided into altered (³ 130 mmHg for systolic and/or ³ 80 mmHg for diastolic) or normal BP. Based on the literature, a total of 1.534 SNPs from 57 candidate genes related with BP were selected from the HELENA genome wide association study database.Results: From 1534 SNPs available, An initial screening of SNPs univariately associated with BP (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with BP (p < 0.05) in the multivariate model. The unweighted GRS (uGRS) and weighted GRS (wGRS) were estimated. To validate the GRSs, the area under the curve was explored using ten-fold internal cross-validation for uGRS (0.796) and wGRS (0.803). Further covariates of interest were added to the analyses, obtaining a higher predictive ability.Conclusions: Both GRSs, could be useful to evaluate the genetic predisposition to hypertension in European adolescents.
A Fast Task Planning System for 6R Articulated Robots Based on Inverse Kinematics
Authors: Lai Yuan-Lung 
Published: September 2022

Abstract
Robots are becoming increasingly popular in workplaces to work next to humans and may always need humans to program them for tasks. Technicians could make mistakes that cause unexpected consequences. Robots bring eventful impacts to the workplace, benefiting from the advantages of implementing any technology should be based on the premise of safety. This work proposes a systematic method to establish a postprocessor module for any specified 6R Articulated Robot. Instead of obsessively emphasizing to achieve the desired locations and orientations by hand guiding grab and drag a robotic arm for operation in teaching mode, the significant end-effector poses are calculated to form a new path for the joints efficiently in this study. Since robotic motion control is usually a complex system whose users must be well trained and acquainted with using them. There is a need for a GUI solution that can provide convenient and intuitive robotic motion control on the current location of the user independently, easy setup, arrangement, adjustment, and monitoring robot motion tasks. The proposed system simplifies the interaction between the technician and the industrial robotic arm in the case of robotic motion control and tracking at a distant location. The presented method is fully adapted to alternate between joint angles and end-effector poses on a graphic user interface system. Examples with specified posture and predefined movements are demonstrated for corroborating the algorithm. The results show considerable efficiency and reliability in path planning and are fully supported for automatic path generation.
Synthesis of prebiotic organics from CO2 by catalysis with meteoritic and volcanic particles
Authors: Peters Sophia , Semenov Dmitry , Hochleitner Rupert , Trapp Oliver 
Published: September 2022

Abstract
The emergence of prebiotic organics was a mandatory step toward the origin of life. The significance of the exogenous delivery versus the in-situ synthesis from atmospheric gases is still under debate. We experimentally demonstrate that iron − rich meteoritic and volcanic particles activate and catalyze the fixation of CO2, yielding the key precursors of life − building blocks. This catalysis is robust and produces selectively aldehydes, alcohols, and hydrocarbons, independent of the redox state of the environment. It is facilitated by common minerals and tolerates a broad range of the early planetary conditions (150 − 300°C, ≳9 bars, wet or dry climate). We find that up to 3 ⋅ 108 kg/year of prebiotic organics could have been synthesized by this large-scale process from the CO2 in the atmosphere on Hadean Earth.
Application of response surface methodology for methylene blue removal using an innovative ZIF-8/NiFe2O4/ halogen lamp system
Authors: faraji afsaneh , mehrdadi nasser 
Published: September 2022

Abstract
In this present research, magnetic nanoparticles of ZIF-8/NiFe2O4 were synthesized using a green and simple method to photodegrade methylene blue in presence of visible-light irradiation. The structures and morphologies properties of the as-synthesized nanoparticles were characterized by XRD, FTIR, SEM, TEM, and PL for individual ZIF-8, NiFe2O4, and ZIF-8/NiFe2O4 materials. Response surface method (RSM) by considering the central composite design (CCD) was used to design the experiments and optimize the process. The F-value (248.26) and p-value < 0.0001 imply that the model is significant. The obtained RSM model with R2 = 0.996 showed a satisfactory correlation between the predicted values and experimental results of MB removal. The maximum decolorization efficiency of MB was obtained under the optimum experimental conditions of 0.044 g/100mL catalyst dose, 5 mg/L initial dye concentration, 150 min irradiation time, and dye solution pH of 7.4.
Genetic analysis of low-grade adenosquamous carcinoma of the breast that progressed to high-grade metaplastic carcinoma
Authors: Kawachi Kae , Tang Xiaoyan , Kasajima Rika , Yamanaka Takashi , Shimizu Eigo , Katayama Kotoe , Yamaguchi Rui , Yokoyama Kazuaki , Yamaguchi Kiyoshi , Furukawa Yoichi , Miyano Satoru , Imoto Seiya , Yoshioka Emi , Washimi Kota , Okubo Yoichiro , Sato Shinya , Yokose Tomoyuki , Miyagi Yohei 
Published: September 2022

Abstract
Low-grade adenosquamous carcinoma (LGASC) is a rare type of metaplastic carcinoma of the breast (MBC) with an indolent clinical course. A few cases with high-grade transformation have been reported; however, their genetic alterations remain unclear. This study was designed to explore the somatic genetic characteristics of LGASC with transformation to high-grade MBC. Whole-genome sequencing analysis was performed on five MBCs from four patients, including one case with matching primary LGASC and lymph node metastatic tumor consisting of high-grade MBC with a predominant metaplastic squamous cell carcinoma pattern (MSC) that has progressed from LGASC, and three de novo MSC. Both LGASC and its associated MSC, unlike de novo MSC, had no TP53 mutation and tended to have fewer structural variants than de novo MSC. Both LGASC and its associated MSC had common mutations and copy number alterations, including GNAS R844C, which shows an increase in its allele frequency in MSC. These results indicated that LGASC and its associated MSC were ancestry clonal and that clonal selection occurred during progression. MSC associated with LGASC had additional pathogenic deletions of multiple tumor suppressor genes caused by, for example, SMAD4–DCC fusion. Reverse transcription polymerase chain reaction, followed by Sanger sequencing, confirmed this fusion transcript in both LGASC and its associated MSC; however, chimera proteins were not detected by Western blotting. SMAD4 protein expression had already decreased at the stage of LGASC, which may have contributed to the tumorigenesis of LGASC. In conclusion, not only LGASC but also its associated high-grade MBC may be genetically different from de novo high-grade MBC. The progression from LGASC to high-grade MBC may concern the concentration of the driver mutation caused by clonal selection and inactivation of tumor suppressor genes.
The breast surgeon in the molecular era: the PD-1 single‐nucleotide polymorphism rs11568821 and rs2227981 as a novel prognosis model in a triple-negative breast cancer patient
Authors: Boguszewska-Byczkiewicz Katarzyna , Wow Thomas , Szymańska Bożena , Kośny Michał , Kolacinska-Wow Agnieszka 
Published: September 2022

Abstract
Introduction: The aim of the study is to determine the relationship between polymorphisms rs11568821 C/T and at rs2227981 G/A in the programmed cell death 1 gene (PDCD1) and the clinicopathologic characteristics of triple negative breast cancer patient (TNBC). Material and Methods: The study included 30 TNBC patients and 30 healthy controls. Genotyping was performed with allelic discrimination using PCR with TaqMan SNP Genotyping Assays. Results: The presence of CC/CT in rs11568821and GG/AG in rs2227981 were not associated with the risk of progression of TNBC. The correlation between rs11568821 minor allele distribution and risk of TNBC has borderline significance (p=0.0619). The rs2227981 polymorphism has a significant association with grade G (G3, p=0.0229). There was a trend toward significance (p=0.063448) in the minor allele presentation and Ki67>20% for rs2227981. Other clinical features (e.g. age, TNM stage) did not significantly correlate with the rs11568821 or the rs2227981 polymorphism. Conclusion: rs2227981 is associated with grading; hence PDCD1 can be used as a prognostic marker in TNBC.
Study on the infrasound characteristics of the Tonga volcano in Chinese Mainland on January 15, 2022
Authors: LIU SHUANGQING , XUE YAN , CHEN SONG , YAO HUIQIN , JIN DALI , WANG YIXI , LI YUE 
Published: September 2022

Abstract
Based on the barometric data that recorded by the seismic monitoring network in Chinese Mainland, the primary infrasonic periods and relative arrival times of 462 stations are obtained with the aid of Meyer’s wavelet decomposition, Welch’s periodogram spectrum estimation and waveform cross-correlation, etc. By extracting the seismic Rayleigh waves of two IRIS stations in the South Pacific and comparing them with the synthetic seismograms, the time of the first two large volcanic eruptions and the largest volcanic eruption are credibly deduced, and then the travel times and propagation speeds of the primary infrasonic waves are obtained. In order to further explain the subsequent confused infrasound phases on pressure, a series of numerical simulations with the acoustic-gravity wave propagation equation are successfully applied to yield highly similar waves corresponding to the barometric records, which indicates that the eruption source contains more than 10 events in an hour. From the above analysis, major conclusions are obtained as followings: (1) the primary pressure disturbance of the Tonga volcano eruption appears to be a simple bulge; however, it is in fact a complex wave composed of multiple eruptions. Its largest eruption is about 13 minutes later than the first large eruption of the very day. (2) Besides the tropospheric propagation, a clear infrasonic phase that propagates in the stratosphere is also observed in some stations, and its amplitude is about a fifth of the primary infrasound. The waves propagating in the stratosphere may have been apparently delayed because of travelling against the westerly wind. (3) The group velocity of the primary infrasound wave from the troposphere is about 308m/s. Its average period is 70 minutes, and its wavelength is about 1300km. Its arrival deviation at each station is negatively correlated with the difference of the near-surface air temperature between North China and South China. However it is challenging to accurately estimate the parameters of the subsequent waves propagating in the stratosphere or along the other side of the Earth due to their low SNR, even though it would be roughly estimated that the speed of the propagation in the stratosphere is only about 225m/s. (4) The phenomenon that there are much smaller periods and later arrivals at the stations within 200km around Beijing may be related to the significant cooling with 12℃ change, which appears from Ulantoba, Outer Mongolia, to Beijing and begins from the noon of January 15 in Beijing time.
Microvessel network, CGRP and NPY distribution, and CBCT image assessments of the mandibular canal between dentulous and edentulous cadavers using principal component analysis
Authors: Takiguchi Masachika , Sato Iwao , Ueda Yoko , Kawata Shinichi , Nagahori Kenta , Omotehara Takuya , Yakura Tomiko , Li Lian , Itoh Masahiro 
Published: September 2022

Abstract

Objectives
This study focused on the detailed distribution of microvessels in the mandibular canal (MC) and the localized expression of neurotransmitters to assess the relationship between microvessel supply and MC structure using cone-beam computed tomography (CBCT) for safe and reliable dental implant treatment.
Materials and methods
In this study, mandibles from 45 sides of 23 human cadavers aged 76–104 years were examined microscopically, immunohistochemically and by CBCT analysis. These data were further evaluated by principal component analysis (PCA).
Results
The MC structure was classified into three types, including complete (57.0%, 228/400), partial (33.8%, 135/400) and unclear (9.2%, 37/400), for dentulous and edentulous subjects. Calcitonin gene-related peptide- and neuropeptide Y-positive reactions were mainly found in the inferior region of the MC. PCA results revealed that developed capillaries were mainly localized in the molar regions.
Conclusions
Our findings indicate that microvessels express neurotransmitters on the vasa nervorum of the inferior alveolar nerve and vein and artery. These irregular large microvessels are mainly located in dentulous subjects, which may provide useful information for dental implant treatment.
Clinical Relevance:
The microvessel supply pattern might signify a risk of pain in the molar and premolar regions in dentulous and edentulous subjects undergoing CBCT analysis of the MC for dental implant surgery based on oral health-related quality of life.
A novel negative selection algorithm with hypercube interface detectors for anomaly detection
Authors: Gu Ming , Li Dong , Gong Lanlan , Liu Jia , Liu Shulin 
Published: September 2022

Abstract
Negative selection algorithms play an important role in anomaly detection. Interface detectors are a special negative selection algorithm that completely eliminates outer holes, but there are detection blind areas. In this paper, a novel negative selection algorithm with a hypercube interface detector is proposed. It uses self-sample clusters to construct self space, and boundary self-sample clusters to describe the interface detector. It eliminates the detection blind area and improves the detection rate. To validate the performance of the proposed method, experiments were conducted using the iris dataset, the skin segmentation dataset, and the Breast Cancer of Wisconsin (BCW) dataset. Experimental results show that the proposed method in this paper has a higher detection rate, lower false alarm rate, and fewer detectors than other anomaly detection methods for the same parameters.
Use of C-reactive protein to guide antibiotic therapy in hospitalized patients: a systematic review and meta-analysis
Authors: Dias Raphael Figuiredo , Paula Ana Clara Rivetti Bitencourt , Hasparyk Ursula Gramiscelli , Coutinho Marcos de Oliveira Rabelo Bassalo , Alderete João Rafael Assis , Kanjongo Júlia Chihondo , Silva Renata Aguiar Menezes , Guimarães Nathalia Sernizon , Silva Ana Cristina Simões e , Nobre Vandack 
Published: September 2022

Abstract
Background: C-reactive protein (CRP) is an acute-phase marker used in clinical practice to identify and monitor inflammatory and infectious processes. Recent data suggest that CRP might be useful in guiding antibiotic therapy discontinuation among critical care patients. This meta-analysis analyzed the benefits and risks of CRP-guided protocols to define antibiotic therapy discontinuation in hospitalized patients in comparison with standard treatment. Methods: Studies were searched in four databases: Medline, Embase, CENTRAL, and LILACS. The reference lists of the articles retrieved, and related review studies were hand-screened to find eligible trials that might have been missed. Primary endpoints included the duration of antibiotic therapy for the index episode of infection. The secondary endpoint was the all-cause hospital mortality and infection relapses. Risk of bias was evaluated using the Cochrane Risk of Bias 2.0 tool. Random effects were used to pool the mean differences and odds ratio of individual studies. The protocol was registered in PROSPERO (CRD42021259977).Results: The search strategy retrieved 5209 titles, out of which 03 studies met the eligibility criteria and were included in this meta-analysis. 727 patients were analyzed, of whom 278 were included in the intervention group and 449 were included in the control group. 55,7% of all patients were women. Meta-analysis indicated that experimental groups (CRP-guided) had a shorter duration of antibiotic therapy (days) [MMD= -1.82, 95%IC -3.23; -0.40], with no difference in mortality [OR =1.19 95%IC 0.67-2.12] or occurrence of infection relapse [OR =3.21 95%IC 0.85-12.05] between the two groups. Conclusion: The use of CRP-guided protocol reduced the total amount of time required for antibiotic therapy when compared to standard protocols of treatment in hospitalized patients with an acute bacterial infection. We did not observe statistical differences in mortality and infection relapse rates.
Polynomial Convergence Rates of Piecewise Deterministic Markov Processes
Authors: Roberts Gareth O. , Rosenthal Jeffrey S. 
Published: September 2022

Abstract
We consider piecewise-deterministic Markov processes such as the Bouncy Particle sampler, on target densities with polynomial tails. Using direct drift condition methods, we provide bounds on the polynomial order of the processes' convergence rate to stationary, on both one-dimensional and high-dimensional state spaces, in both total variation distance and f-norm.
The First-time Absence of the Chandler Wobble since 2015 and its Implications for Excitation Processes
Authors: Yamaguchi Ryuji , Furuya Masato 
Published: September 2022

Abstract
The Chandler Wobble period is considered a single time-invariable constant, ~ 1.2 years. To confirm the time-invariability of the Chandler period, we preliminarily estimated the Chandler period using 50 years’ long space geodetic data under the minimum excitation assumption. Unexpectedly, the estimated period has been shortened by more than 60 days since about 2005, which we consider unreal but significant. Moreover, by simple least-squares modeling, we found the Chandler Wobble started to be weaker in 2005 and almost disappeared in 2015. We interpret these results in both excitation and wobble domains as caused by the absence of the Chandler Wobble for the first time in the observation history. Assuming no excitations of the Chandler Wobble since 2005, the rather abrupt damping suggests that the Q-value is below 25, and that the excitation power of the Chandler Wobble should be greater than previously thought. Meanwhile, although the atmosphere and ocean are currently believed to be the excitation sources of the Chandler wobble, the available atmospheric and oceanic angular momentum functions do not show any temporal changes in terms of the excitation power around the Chandler frequency even after 2005, and cannot explain the recent anomaly of the Chandler Wobble.
Association of the rapid decline in kidney function with the rapid deterioration of health-related quality of life in chronic kidney disease: finding from the KNOW-CKD study
Authors: Kim Hyo Jin , Kim Da Woon , Rhee Harin , Song Sang Heon , Park Sue Kyung , Kim Soo Wan , Kim Yeong Hoon , Sung Suah , Oh Kook-Hwan , Seong Eun Young 
Published: September 2022

Abstract
This study aimed to evaluate changes in health-related quality of life (HRQOL) in patients with chronic kidney disease (CKD) according to the decline in kidney function. HRQOL was assessed using the Short from-36 questionnaire composed of a physical component summary (PCS) and mental component summary (MCS). The rapid decline of kidney function was defined as a decline in estimated glomerular filtration rate (eGFR) of > 3 mL/min/1.73 m2/year. The rapid deterioration of HRQOL was defined as higher than the median of the changes in HRQOL values. Among 970 patients, 360 (37.1%) were in the rapid kidney function decline group. In 720 patients who were 1:1 propensity score-matched, the baseline eGFR was not significantly different between the non-rapid and rapid kidney function decline groups. Compared with the baseline PCS, the 5-year PCS decreased in the non-rapid and rapid kidney function decline groups before and after PSM. Five-year MCS significantly decreased only in the rapid kidney function decline group. In propensity score-matched patients, rapid decline in kidney function was significantly associated with the rapid deterioration of PCS (odds ratio [OR]: 1.48; 95% confidence interval [CI]:1.07–2.05; P = 0.018) and MCS (OR:1.89; 95% CI:1.36–2.62; P < 0.001). The rapid decline in kidney function was associated with the rapid deterioration of HRQOL in CKD patients.
Pandemic Policing and Public (Non)compliant Behaviour: Data from Nigeria
Authors: Shodunke Aliu Oladimeji , Oladipupo Sodiq Abiodun , Adeoti Sheriffdeen Olasunkanmi , Olorede Abdulgafar Abidemi , Alowolodu Adebusayo Joel , Seriki Oriyomi Oluwasegun , Akindele Ayobami Habeeb , Isiaka Adam Folorunsho , Adebayo Glory David , Mbanefo Onyinye Faith 
Published: September 2022

Abstract
ObjectivesThe unprecedented nature of COVID-19 pandemic lockdown order projected to contain the pandemic and the global use of the police to enforce the order has necessitated the investigation of public (non-compliant) behavior and police intervention (misconduct). Given that the phases of easing the lockdown and reopening of the economy were already underway in Nigeria in September 2020, four months post-lockdown, this period was deemed suitable to collect the data. Data DescriptionThe data consists of 30 participants’ (25 individuals and five police personnel) views regarding the reasons that exacerbated the violation and the ‘alleged’ unethical practices of police personnel while enforcing the lockdown. However, it benefits the broader scientific community in areas such as policing, disaster risk reduction, pandemic management and public administration. It is valuable in police reforms against unethical practices and gives clear policy directions to policymakers and authorities in managing future public health emergencies. Also, it is useful in understanding the public awareness about the pandemic and public (mis)trust and disposition towards the government authorities on the obedience to law and public health safety advisories to contain a pandemic.