bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital exchange compromises: Teetering priorities of consumers and organizations at the iron triangle
Authors: LaBarge Monica C. , Walker Kristen L. , Azzari Courtney Nations , Bourassa Maureen , Catlin Jesse , Finkelstein Stacey , Gloukhovtsev Alexei , Leonhardt James , Martin Kelly , Rejowicz‐Quaid Maria , Reshadi Mehrnoosh 
Published: July 2022

AbstractSocietal well‐being is challenged by the complexity and intangibility of the compromises inherent in digital exchanges. Increasingly these exchanges rely on technology, with competing priorities that challenge cooperation and communication among key parties involved. The authors examine the factors that drive tensions between consumers and organizations in digital exchanges, as well as how and why interest groups, lawmakers, and bureaucrats (also known as the “iron triangle”) try to mediate these exchanges through policy and regulation. By explicating the nature of these relationships, the authors illustrate various trade‐offs faced by all parties and depict a novel, comprehensive framework to facilitate holistic assessment of the factors underlying these ubiquitous but complex digital relationships with vague ethical stewardship. This framework serves as a lens to help guide business and regulatory policymaking and as a platform for identifying future research opportunities.
Risk factors for hepatitis C virus infection at a large urban emergency department
Authors: Ford James S. , Hollywood Erika , Steuble Bradley , Meng Zichun , Voong Stephanie , Chechi Tasleem , Tran Nam , May Larissa 
Published: July 2022

AbstractIn 2020, Centers for Disease Control and Prevention (CDC) released guidelines recommending HCV screening in all adults 18 years and older. In the current study, we aimed to identify risk factors for HCV infection in an ED population. We performed a retrospective analysis of ED patients ≥ 18 years who were screened for HCV between 28 November 2018, and 27 November 2019, at a single urban, quaternary referral academic hospital. An HCV‐antibody immunoassay (HCV‐Ab) was used for screening; positive results were confirmed by measuring HCV ribonucleic acid (RNA). The outcome of interest was the number of new HCV diagnoses (presence of viremia by HCV RNA testing). Multiple logistic regression models were used to identify risk factors associated with a new HCV diagnosis. 16,722 adult patients were screened for HCV (mean age: 46 ± 15 years; 51% female). HCV seroprevalence was 5%. Independent risk factors for HCV included increasing age [10‐year aOR 1.26 (95% CI 1.23, 1.30)], male sex [aOR 1.25 (95% CI 1.03, 1.51)], undomiciled housing status [aOR 2.8 (95% CI 2.3, 3.5)], history of tobacco use [aOR 3.0 (95% CI 2.3, 3.9)], history of illicit drug use [aOR 3.6 (95% CI 2.9, 4.5)], Medicaid insurance status [aOR 4.0 (95% CI 2.9, 5.5)] and Medicare insurance status [aOR 1.6 (95% CI 1.1, 2.2)].The ED services a high‐risk population with regards to HCV infection. These data support universal screening of ED patients for HCV. Risk factor profiles could improve targeted screening at institutions without universal testing protocols.
Evaluation of aerodigestive disease and diagnosis of sliding hiatal hernia in brachycephalic and nonbrachycephalic dogs
Authors: Luciani Elizabeth , Reinero Carol , Grobman Megan 
Published: July 2022

AbstractBackgroundAerodigestive diseases (AeroD), hybrid disorders between the respiratory and gastrointestinal (GI) tracts, may present without GI signs. Sliding hiatal hernia (sHH) is an important AeroD in brachycephalic dogs linked to respiratory pathology. The spectrum of other AeroD and respiratory clinical signs (CS) in brachycephalic and nonbrachycephalic dogs with sHH is unknown.ObjectivesCharacterize CS of AeroD in dogs with sHH, compare CS between brachycephalic and nonbrachycephalic dogs, and compare thoracic radiographs and videofluoroscopic swallow study (VFSS) for diagnosing sHH.AnimalsSixty‐seven client‐owned dogs with sHH.MethodsMedical records of dogs with sHH presented to the veterinary teaching hospitals at Auburn University and the University of Missouri between 1 January 2009 and 31 December 2020 were retrospectively reviewed. Between group, comparisons were made using Mann‐Whitney test, Chi‐square analysis, and Spearman correlation (P < .05).ResultsDogs with sHH presented with exclusively GI signs (28/67), mixed respiratory and GI signs (22/67), or with exclusively respiratory signs (17/67). Wheras brachycephalic dogs were not significantly more likely to present with respiratory CS (P = .145), they were younger (P < .001), and more likely to present in respiratory distress (P = .02), and with radiographic evidence of aspiration pneumonia (P < .001) compared to nonbrachycephalic dogs. Six of 12 dogs with normal thoracic radiographs having sHH presented with respiratory CS. For detection of sHH, VFSS was superior to radiographs (P < .001).Conclusions and Clinical ImportanceDogs with sHH may present with exclusively respiratory signs. Respiratory signs may be more severe in brachycephalic compared to nonbrachycephalic dogs. Videofluoroscopic swallow study was superior to thoracic radiographs for detection of sHH in dogs.
Multicentered masked placebo‐controlled phase 2 clinical study of an extended duration transdermal buprenorphine solution for postoperative pain in cats
Authors: Clark Terrence P. , Linton Deborah D. , Freise Kevin J. , Lin Ting‐Li 
Published: July 2022

AbstractA prospective, double‐masked, placebo‐controlled, multicentered phase 2 clinical study was conducted to select the transdermal buprenorphine solution (TBS) dosage for the control of postoperative pain in cats. One‐hundred fifteen (115) cats were randomized to a single topical dose of placebo solution, low‐TBS dosage (1.91–2.07 mg/kg) or high‐TBS dosage (4.27–4.88 mg/kg) prior to surgical reproductive sterilization in conjunction with forelimb onychectomy. The low‐ and high‐TBS doses were applied 2–4 and 1–2 hours prior to surgery. Interactive pain assessments and physiological variables were quantified through 96 hours post‐anesthetic recovery and rescue analgesia was administered any time that analgesia was considered inadequate. Cats requiring rescue analgesia were considered treatment failures. The estimated overall treatment success rates from generalized linear mixed effects model analysis were 0.10 (95% CI: [0.02–0.36]), 0.56 (95% CI: [0.25–0.83]), 0.71 (95% CI: [0.38–0.91]) in the placebo‐, low‐, and high‐TBS dose groups, respectively. Success rates for both TBS treatment groups were superior to placebo. Adverse events were infrequent in all treatment groups although the postoperative body temperatures over the duration of the study were on average 0.31 (95% CI: [0.08–0.55]) and 0.30 (95% CI: [0.05–0.53]) °C higher in low‐ and high‐TBS dose cats, respectively, compared to placebo. It is concluded that both the low‐ and high‐TBS dosages were safe and effective. The high‐TBS dosage resulted in a greater proportion of treatment successes over 96 h, had a more acceptable preoperative application time of 1–2 h prior to surgery, and was therefore selected for further study.
Multicentered masked placebo‐controlled phase 3 clinical study of an extended duration transdermal buprenorphine solution for post‐operative pain in cats
Authors: Clark Terrence P. , Linton Deborah D. , Freise Kevin J. , Lin Ting‐Li 
Published: July 2022

AbstractA prospective, double masked, placebo‐controlled, multicentered phase 3 clinical study was conducted to evaluate the safety and effectiveness of transdermal buprenorphine solution (TBS) for the control of post‐operative pain in cats. A total of 228 cats from 12 US investigational sites met the enrollment criteria of which 107 placebo‐ and 112 TBS‐treated cats were included into the per protocol efficacy analysis. The dose of TBS was 8 mg (0.4 ml) to cats 1.2 to 3 kilograms and 20 mg (1 ml) to cats >3 to 7.5 kilograms applied topically to the dorsal unclipped cervical skin 1–2 h prior to the undergoing elective surgical reproductive sterilization in conjunction with forelimb onychectomy. Interactive pain assessments and physiological variables were quantified through 96 h following recovery from anesthesia, and rescue analgesia was administered any time that pain control was scored inadequate. Cats requiring rescue analgesia or experiencing an adverse event suspected to be treatment related were considered treatment failures. Sixty‐five and 23 cats were considered treatment failures in the placebo and TBS groups, respectively, with most occurring on the day of surgery. The treatment success rates were 0.40 (95% confidence interval [CI]: [0.28–0.53]) and 0.81 (95% CI: [0.70–0.89]) in the placebo and TBS groups, respectively, and the difference was significant (p < .05). Adverse events occurred at a similar frequency and were not clinically meaningful in either treatment group. The post‐operative body temperatures over the duration of the study were on average 0.35 (95% CI: [0.20–0.50]) °C higher than baseline in TBS‐treated cats and were not clinically meaningful, an observation typical of opioids in cats. These results serve as substantial evidence that TBS is safe and effective for the control of orthopedic and soft tissue post‐operative pain in cats when a single topical dose is applied 1–2 h prior to surgery.
Spectral reflectance variations of aubrites, metal‐rich meteorites, and sulfides: Implications for exploration of (16) Psyche and other “spectrally featureless” asteroids
Authors: Dibb Steven D. , Bell James F. , Garvie Laurence A. J. 
Published: July 2022

AbstractThe 350–2500 nm reflectance spectra of five enstatite achondrites (aubrites), five metal‐rich chondrites (CBa, CBb, CH/CBb, and ungrouped), and seven sulfide mineral samples (three troilites, pyrrhotite, pentlandite, a mixture of pentlandite and chalcopyrite, and oldhamite) have been measured to search for spectral parameters that may offer insight into the surface composition of so‐called “spectrally featureless” asteroids. Spectral data were acquired from powders, slabs, and hand samples. Aubrites exhibit high reflectance, generally positive slopes at visible wavelengths, and low‐to‐negative infrared slopes, consistent with E‐/Xe‐type asteroids. The metal‐rich chondrites exhibit low reflectance, moderate visible slopes, and low near‐infrared slopes, somewhat consistent with M−/X‐complex asteroids. The metal‐rich chondrites exhibit absorption features at ~900 nm arising from Fe2+‐bearing silicates. Sulfides exhibit low to moderate reflectance and high visible and near‐infrared slope, intermediate to the T‐ and L‐type asteroids. The D‐type asteroids, which have high visible and near‐infrared slopes, are not well‐matched by sulfides. Spectral data of the largest M−/X‐type asteroid, (16) Psyche, are consistent with both powder from the Isheyevo CH/CBb chondrite and powder of meteoritic troilite. The data presented here will support interpretation of data returned from future spacecraft missions to “spectrally featureless” asteroids, like the Psyche, Lucy, and DART/Hera missions.
Glucose sensing by regulator of G protein signaling 1 (RGS1) plays a crucial role in coordinating defense in response to environmental variation in tomato
Authors: Wang Jiao , Wang Anran , Luo Qian , Hu Zhangjian , Ma Qiaomei , Li Yimei , Lin Teng , Liang Xiao , Yu Jingquan , Foyer Christine H. , Shi Kai 
Published: July 2022

Summary

Low light intensities affect the outbreak of plant diseases. However, the underlying molecular mechanisms remain poorly understood.

High‐performance liquid chromatography analysis of tomato (Solanum lycopersicum) revealed that apoplastic glucose (Glc) levels decreased in response to low light. Conversely, low‐light‐induced susceptibility to Pseudomonas syringae pv tomato (Pst) DC3000 was significantly alleviated by exogenous Glc treatment. Using cell‐based biolayer interferometry assays, we found that Glc specifically binds to the tomato regulator of G protein signaling 1 (RGS1). Laser scanning confocal microscopy imaging revealed that Glc triggers RGS1 endocytosis, which influences the uncoupling of the RGS1‐Gα (GPA1) and GPA1‐Gβ (SlGB1) proteins, in a dose‑ and duration‐dependent manner.

Analysis of G protein single and double mutants revealed that RGS1 negatively regulates disease resistance under low light and is required for Glc‐enhanced defense. Downstream of RGS1‐Glc binding, GPA1 negatively mediates the light‐intensity‐regulated defense, whereas SlGB1 positively regulates this process.

These results reveal a novel light‐intensity‐responsive defense system that is mediated by a Glc–RGS1–G protein signaling pathway. This information will be critical for future investigations of how plant cells sense extracellular sugars and adjust defense under different environments, as well as for genetic engineering approaches to improve stress resilience.
Covid‐19 in America: Global supply chain reconsidered
Authors: Ngo Christine Ngoc , Dang Huong 
Published: July 2022

AbstractThis research asks: To what extent has America's reliance on the global supply network aggravated the country's public health and economic crisis; and how did the American government respond to supply chain weaknesses during the early years of the Covid‐19 pandemic? This study first assesses important conceptual considerations that explain the expansion of global value chains and the growth of trade interdependencies among nations. Next, an analytical case study observes (1) America's supply chain vulnerability through three major waves of infection, (2) the difficulty to mend weaknesses in the supply linkages once the novel coronavirus spread globally and (3) American government's failures to both anticipate and respond to supply shortages, especially in the health sector. Trump administration's policies failed to ensure a reliable supply of simple personal protective equipment (PPE) for healthcare professionals and hospitals throughout the first three waves of infection. Moreover, state and federal governments' substantial reliance on large manufacturers who have established procurement relationship with government led to continuous nationwide supply shortages throughout 2020. The federal government's inability to engage small and medium manufacturers in the production of critical supplies of PPE and diagnostic tests deepened and prolonged the devastating impacts of the pandemic. Our case study demonstrates that the American government needs to rethink the country's substantial reliance on the global supply chain, and the specific requirements to boost domestic manufacturing capacity. The revitalisation of America's manufacturing ability and the local supply networks will boost the productive power of the nation, strengthen resiliency, reduce vulnerability in disruptive times and prepare the nation for future crises.
Allogeneic peripheral blood haematopoietic stem cell transplantation for the treatment of dogs with high‐grade B‐cell lymphoma
Authors: Gareau Alexandra , Sekiguchi Tomoko , Warry Emma , Ripoll Alexandra Z. , Sullivan Edmund , Westfall Theresa , Chretin John , Fulton Lisa M. , Harkey Michael , Storb Rainer , Suter Steven E. 
Published: July 2022

AbstractAutologous peripheral blood haematopoietic stem cell transplantation (HCT) cures 33%–40% of dogs with high‐grade B‐cell lymphoma. We hypothesized, based on human allogeneic bone marrow transplantation literature, that transplanting dogs using canine donor leukocyte‐matched CD34+ cells would lead to fewer relapses and increased cure rates. We retrospectively reviewed medical records of dogs diagnosed with high‐grade B‐cell lymphoma who received an identical allogeneic HCT. A total of 15 dogs transplanted at four facilities were identified. Five of fifteen dogs relapsed before transplant. The mean number of donor CD34+ cells/kg harvested and infused into recipient dogs was 8.0 × 106/kg (range: 2.08 × 106/kg–2.9 × 107/kg). The median disease‐free interval and overall survival of all dogs was 1095 days (range: 9–2920 days) and 1115 days (range: 9–2920 days), respectively. Two of five dogs, not in remission at transplant, died in the hospital. The median disease‐free interval and overall survival of the remaining three dogs was 25 days (range: 15–250 days) and 1100 days (range: 66–1902 days), respectively. The median disease‐free interval and overall survival of the 10 dogs who had not relapsed was 1235 days (range: 19–2920 days) and 1235 days (range: 19–2920 days), respectively. One dog died soon after discharge of presumed gastric‐dilatation‐volvulus. Eight of nine remaining dogs lived >4 yrs post‐alloHCT, leading to a cure rate of 89%. Acute graft versus host disease was seen in three dogs. These results suggest that allogeneic HCT can cure ~50% more dogs than those treated with autologous HCT.
CT measurement of prostate volume using OsiriX® viewer is reliable, repeatable, and not dependent on observer, CT protocol, or contrast enhancement in dogs
Authors: Salonen Hanna M. , Åhlberg Tuuli M. , Laitinen‐Vapaavuori Outi M. , Mölsä Sari H. 
Published: July 2022

AbstractComputed tomography (CT) is an established method for evaluating dogs with suspected prostatic disease; however, publications assessing the effects of varying factors on prostate volume measurements are lacking. The objectives of this two‐part, observer agreement, methods comparison study were to assess observer agreement and the effects of varying CT technical parameters for volume measurements of canine prostate glands on CT images using OsiriX® DICOM viewer software. In the first retrospective study, two observers measured prostate volumes of 13 client‐owned dogs thrice on noncontrast and contrast CT images. In the second prospective study, two observers measured the prostate volume of 10 cadavers using five different CT protocols and eight cadavers using three slice thicknesses. Observer agreement analyses were performed, and prostatic CT volume measurements were compared with water displacement volume measurements. Intra‐ and interobserver variability and the effect of contrast enhancement were found to be minimal when a one‐way analysis of variance model and intraclass correlation coefficients were used. No significant differences emerged between different protocols and slice thicknesses using a linear mixed effects model. When the prostate CT volume was compared using a Bland–Altman plot with the reference volume acquired by the water displacement method, agreement without consistent bias between the methods was shown, and over 90% of measurements were located within the 95% limits of agreement. The findings supported using OsiriX® software for CT prostatic volume measurements in dogs.
Platinum(II) Acetylacetonate Complex Based on 5-(3-Aminophenyl)-2-(2-thienyl)pyridine: Synthesis, Crystal Structure, and Photophysical Properties
Authors: Kopchuk D. S. , Slepukhin P. A. , Taniya O. S. , Krinochkin A. P. , Zyryanov G. V. , Chupakhin O. N. 
Published: July 2022

Abstract
The Pt(II) acetylacetonate complex [(L)Pt(Acac)] based on aminophenyl-substituted 2-(2-thienyl)pyridine (L) was synthesized, its photophysical properties were studied and compared with these properties for a similar complex containing no amino group in the ligand. The structure of the complex was confirmed by X-ray diffraction (CIF file CCDC no. 2144689), 1H and 13C NMR spectroscopy, ESI mass spectrometry, and elemental analysis.
Pandemic inequity in a megacity: a multilevel analysis of individual, community and healthcare vulnerability risks for COVID-19 mortality in Jakarta, Indonesia
Authors: Surendra Henry , Salama Ngabila , Lestari Karina D , Adrian Verry , Widyastuti Widyastuti , Oktavia Dwi , Lina Rosa N , Djaafara Bimandra A , Fadilah Ihsan , Sagara Rahmat , Ekawati Lenny L , Nurhasim Ahmad , Ahmad Riris A , Kekalih Aria , Syam Ari F , Shankar Anuraj H , Thwaites Guy , Baird J Kevin , Hamers Raph L , Elyazar Iqbal R F 
Published: July 2022

IntroductionWorldwide, the 33 recognised megacities comprise approximately 7% of the global population, yet account for 20% COVID-19 deaths. The specific inequities and other factors within megacities that affect vulnerability to COVID-19 mortality remain poorly defined. We assessed individual, community-level and healthcare factors associated with COVID-19-related mortality in a megacity of Jakarta, Indonesia, during two epidemic waves spanning 2 March 2020 to 31 August 2021.MethodsThis retrospective cohort included residents of Jakarta, Indonesia, with PCR-confirmed COVID-19. We extracted demographic, clinical, outcome (recovered or died), vaccine coverage data and disease prevalence from Jakarta Health Office surveillance records, and collected subdistrict level sociodemographics data from various official sources. We used multilevel logistic regression to examine individual, community and subdistrict-level healthcare factors and their associations with COVID-19 mortality.ResultsOf 705 503 cases with a definitive outcome by 31 August 2021, 694 706 (98.5%) recovered and 10 797 (1.5%) died. The median age was 36 years (IQR 24–50), 13.2% (93 459) were <18 years and 51.6% were female. The subdistrict level accounted for 1.5% of variance in mortality (p<0.0001). Mortality ranged from 0.9 to 1.8% by subdistrict. Individual-level factors associated with death were older age, male sex, comorbidities and age <5 years during the first wave (adjusted OR (aOR)) 1.56, 95% CI 1.04 to 2.35; reference: age 20–29 years). Community-level factors associated with death were poverty (aOR for the poorer quarter 1.35, 95% CI 1.17 to 1.55; reference: wealthiest quarter) and high population density (aOR for the highest density 1.34, 95% CI 1.14 to 2.58; reference: the lowest). Healthcare factor associated with death was low vaccine coverage (aOR for the lowest coverage 1.25, 95% CI 1.13 to 1.38; reference: the highest).ConclusionIn addition to individual risk factors, living in areas with high poverty and density, and low healthcare performance further increase the vulnerability of communities to COVID-19-associated death in urban low-resource settings.