bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetically Separable Fe3O4@poly(m‐phenylenediamine)@Cu2O Nanocatalyst for the Facile Synthesis of 5‐phenyl‐[1,2,3]triazolo[1,5‐c]quinazolines
Authors: Rawat Manish , Taniike Toshiaki , Rawat Diwan S. 
Published: January 2022

AbstractHerein we report a facile approach for the preparation of a magnetically separable Fe3O4@poly(m‐phenylenediamine)@Cu2O nanocatalyst and its catalytic efficiency in the synthesis of 5‐phenyl‐[1,2,3]triazolo[1,5‐c]quinazolines from (E)‐1‐bromo‐2‐(2‐nitrovinyl)benzenes, aldehydes, and sodium azide under mild reaction condition is described. The morphology, chemical composition, interior structure and magnetic properties of the Fe3O4@PmPDs@Cu2O nanocomposites were studied using powder X‐ray diffraction, scanning electron microscopy, high resolution transmission electron microscopy, energy dispersive X‐ray spectroscopy, X‐ray photoelectron microscopy, vibrating sample magnetometer and nitrogen adsorption‐desorption technique. The as‐prepared Fe3O4@PmPDs@Cu2O nanocatalyst was simply recovered using external magnet and reused up to successive six runs with no obvious loss in its catalytic efficiency and structural integrity (confirmed by powder X‐ray diffraction and transmission electron microscopy of recycled nanocatalyst) along with low leaching of copper (2.32 ppm) and iron (0.008 ppm) ions. The present protocol has a broad substrate scope with high yield in shorter reaction time and it does not require any additive or base. Overall, it has better green chemistry metrices like low E‐factor (0.93), process mass intensity (1.93), high reaction mass efficiency (51.9 %) and carbon efficiency (95 %).
Determination of temperature dependent static Young's modulus of refractory ceramics using RUL tests
Authors: Henze Michel , Reichert Wanja , Tonnesen Thorsten , Telle Rainer , Hirt Gerhard 
Published: January 2022

AbstractRefractory linings are, in addition to loads due to corrosion and creep processes, particularly affected by thermomechanical stresses caused by the restricted thermal expansion of the lining. These stresses can occur within individual components as well as in bricks and can lead to plastic deformation, cracks, and material failure. Thus, comprehensive knowledge about thermomechanical behavior is mandatory for an accurate prediction of occurring stresses to design load‐optimized linings. This paper presents a method for utilizing refractoriness under load (RUL) tests to determine a temperature dependent static Young's modulus for refractories. In a first step, RUL tests with a negligible load are carried out in order to determine the materials temperature dependent thermal expansion coefficient. Afterwards, several RUL tests with higher loads are carried out. The measured data of change in temperature and length are then corrected by the thermal expansion and used to construct elastic lines for several temperatures, where the elastic slope is determined using the change in length and the respective load. Thus, Young's modulus for several temperatures can be determined. The obtained values for the Young's modulus are then compared to resonant frequency damping analysis measurements and validated using a finite element (FE) model of the RUL test.
Asymmetric Catalytic Assembly of Triple‐Columned and Multilayered Chiral Folding Polymers Showing Aggregation‐Induced Emission (AIE)
Authors: Wang Jia‐Yin , Tang Yao , Wu Guan‐Zhao , Zhang Sai , Rouh Hossein , Jin Shengzhou , Xu Ting , Wang Yu , Unruh Daniel , Surowiec Kazimierz , Ma Yanzhang , Li Yunze , Katz Courtney , Liang Hongjun , Cong Weilong , Li Guigen 
Published: January 2022

AbstractInvited for the cover of this issue are Guigen Li's groups at Texas Tech University and Nanjing University. The cover artwork shows that chirality patterns exist from universal to molecular levels showing light emission properties. Read the full story of multilayer 3D chirality and its asymmetric catalytic synthesis at 10.1002/chem.202104102.
Radical SAM‐Dependent Demetallation of Heme
Authors: Cheng Jinduo , Ding Wei , Zhang Qi 
Published: January 2022

Comprehensive SummaryDemetallation of heme to release iron is a chemical difficult reaction and is highly rare in biochemistry, with apoferritin as the only known enzyme responsible for this process. Here we show the heme degradation enzyme ChuW catalyzes heme demetallation besides its known methyltransferase activity (which converts heme to a ring‐open product anaerobilin). We show the demetallation activity of ChuW is radical SAM‐dependent, and likely involves the same set of intermediates involved in the anaerobilin‐producing pathway. The ChuW‐catalyzed demetallation reaction does not require external reductant, and can occur on several heme analogs with different metal centers. These findings establish a brand‐new chemistry in the radical SAM enzymes, highlighting the remarkable catalytic diversity of this superfamily of enzymes.
Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer
Authors: Megaro Giacomina , Miele Evelina , Spinelli Gian Paolo , Alessi Iside , Del Baldo Giada , Cozza Raffaele , Russo Ida , De Pasquale Maria Debora , Cefalo Maria Giuseppina , Tomà Paolo , Carai Andrea , Di Ruscio Valentina , De Ioris Maria Antonietta , Mastronuzzi Angela 
Published: January 2022

AbstractBackgroundLung cancer is the leading cause of cancer‐related death. NSCLC accounts for 80–90% of cases. In young patients, adenocarcinoma is the most frequent histotype and 3–7% expresses the rearrangement of ALK oncogene, sensitive to TKIs. Crizotinib is the first ALK inhibitor approved by the FDA.CaseWe present a case of a 17‐year‐old male with metastatic treatment‐naïve ALK‐positive adenocarcinoma. He was treated with crizotinib and obtained a prolonged response with PFS of 33 months.ConclusionCrizotinib can be extremely effective in adolescents with treatment‐naïve ALK‐positive NSCLC but fail to prevent a central nervous system relapse. Resistance mechanisms need to be investigated.
Population Pharmacokinetics Analysis of Pemigatinib in Patients With Advanced Malignancies
Authors: Ji Tao , Chen Xuejun , Liu Xiang , Yeleswaram Swamy 
Published: January 2022

AbstractPemigatinib is a fibroblast growth factor receptor 1–3 inhibitor used to treat cholangiocarcinoma. A compartmental population pharmacokinetics model was developed using data from 318 patients with cancer enrolled in a phase 1 dose‐escalation/dose‐expansion study, a phase 1 Japanese PK bridging study, and a phase 2 cholangiocarcinoma study. The final model for pemigatinib was a 2‐compartment disposition model with first‐order absorption and linear elimination. All fixed‐ and random‐effect parameters were estimated with good precision, and no apparent biases in the overall model fit were observed. For females, the estimated typical pemigatinib absorption rate constant (ka) and oral clearance (CL/F) were estimated (1.49 L/h and 10.3 L/h, respectively). For males, the typical apparent clearance and ka are 19.0% higher and 56.5% lower, respectively, compared with females. Typical apparent volume of distribution of the central compartment (Vc/F) and peripheral compartment for a 73.3‐kg patient was estimated to be 122.0 L and 80.1 L, respectively; both increased with body weight. Phosphate binder coadministration decreases typical pemigatinib CL/F by 14.1%. Proton pump inhibitor coadministration increases typical pemigatinib apparent Vc/F by 24.4%. Phosphate binders and sex contribute a <20% change to CL/F. The impact of the investigated covariates on pemigatinib pharmacokinetics are not clinically significant.
Content‐based image retrieval for super‐resolutioned images using feature fusion: Deep learning and hand crafted
Authors: Pathak Debanjan , Raju Undi Surya Narayana 
Published: January 2022

AbstractAn innovative image retrieval agenda by concatenating deep learning features from GoogleNet and low‐level features from HSI and RGB color space is proposed in this article. Most of the CNN features suffer from loss of information due to image resize as a pre‐processing stage. To reduce this information loss super‐resolution technic is used for resizing images. An improved form of dot‐diffused block truncation coding is used for extracting RGB handcraft features. To discover the interdependencies between color and intensity component of an image, interchannel voting between hue, saturation, and intensity component is calculated as a color feature in HSI space. Histogram of orientated gradient (HOG) feature is used as shape feature. Five standard performance parameters, average precision rate, average recall rate, F‐Measure, Average Normalized Modified Retrieval Rank, and Total Minimum Retrieval Epoch, are applied on nine image datasets: Corel‐1K, Corel‐5K, Corel‐10K, VisTex, STex, ColorBrodatz and three subsets of ImageNet dataset for evaluation process of proposed method. For all dataset the best performance is achieved by the proposed method with respect to all performance parameters.
Plant waterflow restrictions among sweet corn lines related to limited‐transpiration trait
Authors: Sinclair Thomas R. , Jafarikouhini Nahid 
Published: January 2022

AbstractWhile partial stomata closure under elevated vapor pressure deficit (VPD), that is, a limited‐transpiration trait resulting in soil water conservation and crop drought resiliency, has been identified in a few lines in all major crop species, the basis for the trait is not resolved. Since changes in stomatal aperture are associated with hydraulic processes, properties influencing waterflow in the plant are candidates associated with expression of limited‐transpiration. In a previous study with leaves of sweet corn (Zea mays L.), limited‐transpiration was only weakly associated with the effect of silver ion, an aquaporin inhibitor, on leaf transpiration rate. The hypothesis was explored that total aquaporin activity rather than only silver‐sensitive aquaporins may be more relevant in the expression of limited transpiration. Leaves were fed potent aquaporin inhibitors of mercury and peroxide which both resulted in greater transpiration inhibition than silver, but there were no differences in response among lines. A second hypothesis was that there may be a major limitation of waterflow in the root system accounting for genotypic variation in expression of the limited‐transpiration trait. No differences in root hydraulic conductance were found among sweet corn lines differing in the limited‐transpiration trait. However, it was discovered that the root conductance decreased during the photoperiod in all tested lines. Measurements of root hydraulic conductance in response to a silver treatment showed differences among lines with an association between the VPD breakpoint for limited transpiration and transpiration sensitivity to the silver treatment.
Expression of unique gene signature distinguishes TCRαβ+/BCR+ dual expressers from CD3+CD14+ doublets
Authors: Jie Chunfa , Ahmed Rizwan , Hamad Abdel Rahim A. 
Published: January 2022

AbstractIncreasing evidence shows pathophysiological significance of rare immune cells, necessitating the need for reliable and proper methods for their detection and analysis. We have recently identified a new lymphocyte that coexpresses lineage markers of T‐ and B‐cells including T cell receptor and B cell receptor (called dual expressers, DEs). Because of the peculiar phenotype of DEs, we used multiple techniques to authenticate their identity (fluorescence‐activated cell sorting [FACS], scRNAseq, EBV cell lines, and imaging flow cytometry). In an recent article published in this journal, Burel and colleagues successfully detected DEs using FACS and imaging microscopy. Yet they claimed, based on the profile of what they called naturally occurring CD3+CD14+ T cell/monocyte complexes that the scRNAseq signature of DEs resembles that of cell–cell complexes. Serious flaws in their analysis, however, invalidate their conclusions. Unlike the CD3+CD14+ complexes, DEs have a distinct identity due to expression of a unique set of signature genes. Without a clear explanation, Burel and colleagues excluded these genes from their analysis, thereby effectively stripped DEs from their identity. Inclusion of these genes as described in this communication restores the identity of DEs. Moreover, contrary to the claim of Burel and colleagues, B‐ and T‐cell specific genes are similarly expressed in DE cells.
Performance of a cognitive device‐to‐device network in disaster situation under a collision constraint
Authors: Ghosh Sayanti , Bhowmick Abhijit , Chandra Aniruddha , Roy Sanjay Dhar , Kundu Sumit 
Published: January 2022

SummaryIn this paper, a multi‐hop cognitive radio (CR) enabled device‐to‐device (D2D) network is considered to extend the communication from a functional area (FA) to a non‐functional area (NFA). A D2D user utilizes a cellular user (CU) band in the cognitive mode for information transmission while maintaining the service quality of CUs by satisfying a collision constraint. It transmits with full power in overlay mode, while the power is controlled in underlay mode. We derive the outage probability of the considered D2D network. The main challenge in CR communications lies in the system robustness to uncertainties. In this paper, we also show the impact of the noise power uncertainty in a multi‐hop D2D network. The expressions for throughput and energy efficiency are also developed under collision constraint and noise uncertainty. The outage probability, throughput, and energy efficiency are investigated for several network parameters such as collision probability, sensing time, noise uncertainty, etc. It is observed that the collision constraint and noise uncertainty have significant impacts on network performance. A simulation test‐bed is developed in MATLAB, and the results obtained in the simulation are verified with the analytical results.
Ancillary studies on cell blocks from fine needle aspiration specimens of salivary gland lesions: A multi‐institutional study
Authors: Tabibi Seena , Gabrielson Matthew , Saoud Carla , Davis Katelynn , Wangsiricharoen Sintawat , Lu Ryan , Tondi Resta Isabella , Viswanathan Kartik , Faquin William C. , Baloch Zubair , Maleki Zahra 
Published: January 2022

AbstractBackgroundAncillary studies are commonly performed on cell blocks prepared from fine‐needle aspiration (FNA) specimens. There are limited studies in application of ancillary studies on cell blocks from salivary gland (SG) FNAs. This multi‐institutional study evaluates the role of ancillary studies performed on cell blocks in the diagnosis of SG lesions, and their impact on clinical management.MethodThe electronic pathology archives of three large academic institutions were searched for SG FNAs with ancillary studies performed on cell blocks. The patient demographics, FNA site, cytologic diagnosis, ancillary studies, and surgical follow‐up were recorded. If needed, the cytologic diagnoses were reclassified as per the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).Results117 SG FNA cases were identified including 3, 10, 11, 6, 23, 4, and 60 cases in MSRSGC categories I, II, III, IVa, IVb, V, VI, respectively with surgical follow‐up available ranging from 27% to 100% within each category. Ancillary studies including histochemistry, immunocytochemistry (IHC), and in situ hybridization (ISH) were beneficial in 60%–100% of cases in each category. Risk of malignancy was 100% in both the suspicious for malignancy (V) and malignant (VI) categories. Ancillary studies improved diagnosis in 60% of non‐neoplastic cases (II, 6/10), 100% of benign neoplasm cases (IVa, 6/6), and 98.3% of malignant cases (VI, 59/60).ConclusionJudicious and case‐based ancillary studies performed on SG FNA cell blocks with sufficient material can improve the diagnostic yield by further characterization of the atypical/neoplastic cells, particularly in MSRSGC categories IVa‐VI.
Autophagic and apoptotic cell death induced by the quinoline derivative 2‐(6‐methoxynaphthalen‐2‐yl)quinolin‐4‐amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway
Authors: Begum Habeebunnisa , Chirra Nagaraju , Kumar Dinesh , Murugesan Periyasamy , Kantevari Srinivas , Tangutur Anjana Devi 
Published: January 2022

AbstractPancreatic cancer (PC) is among the most lethal cancers and is resistant to existing therapies, which highlights the need for new and alternative therapeutic treatments. Autophagy is emerging as one of the alternative cell death mechanisms and is well known to cross‐talk with apoptosis. Autophagy can act as a viable option to treat highly resistant PC. The current study investigates and provides insight into the autophagic and apoptotic cell death induced by quinoline derivative 2‐(6‐methoxynaphthalen‐2‐yl)quinolin‐4‐amine (6MN‐4‐AQ) in PC cell lines PANC‐1 and MIA PaCa‐2. Treatment with 6MN‐4‐AQ reduced cell viability in concentration dependent manner (2–16 μM) and inhibited the clonogenic potential of PC cells at a concentration of 4 μM for 24 h. Further, we found that 6MN‐4‐AQ induced both apoptosis and autophagic cell death simultaneously. We identified that 6MN‐4‐AQ induced autophagic cell death by forming cytoplasmic vacuoles, the elevation of autophagy flux, increase in LC3‐II, Beclin‐1 protein expression, and degradation of p62. Moreover, 6MN‐4‐AQ induced apoptosis via Caspase‐3 activation and cleavage of PARP in PC cells. Upon investigating the underlying mechanism associated with 6MN‐4‐AQ induced cell death, it was observed that 6MN‐4‐AQ treatment is able to suppress the Akt/mTOR pathway and induced ER stress leading to the induction of autophagy. Also, 6MN‐4‐AQ treatment suppressed epithelial to mesenchymal transition by reducing the protein expression of SLUG, snail, and vimentin. Subsequently, 6MN‐4‐AQ inhibited cell migration and invasion by down regulating MMP‐7 and MMP‐9 protein expression, suggesting that 6MN‐4‐AQ may serve as a plausible therapeutic agent for PC.
No association between psychiatric symptoms and doses of anabolic steroids in a cohort of male and female bodybuilders
Authors: Amaral Julio X. , Deslandes Andrea C. , Padilha Monica C. , Vieira Neto Leonardo , Osorio Luiz E. , Aquino Neto Francisco Radler , Cruz Marcelo S. 
Published: January 2022

AbstractThe use of androgenic‐anabolic steroids (AAS) can be associated with psychiatric symptoms such as insomnia, anxiety and increased aggressiveness. Although dose‐dependent effects have been observed in some controlled studies, this association is not always seen in the ecological use of AAS. This study utilized WADA's steroid profile of suspicious use of AAS, urinary detection of AAS metabolites and measurement of sexual hormones to confirm recent use of AAS in a cohort of 103 bodybuilders (75 males, 28 females). The majority of participants (61.2%) presented symptoms of agitation, insomnia, increased aggressiveness or depression in the last 3 months. About one‐third of participants presented scores on the HAM‐A anxiety scale equivalent to moderate to severe symptoms of anxiety. A minority of participants (12.6%) presented high to moderate scores on the BPQ aggressiveness scale. The majority of participants (73.8%) presented hyperthymic temperament in the BRIEF‐TEMPS scale. There was no significant difference in the presence of psychiatric symptoms between males and females and no association between psychiatric symptoms and estimated weekly doses of AAS. A negative association was observed between scores on the BPQ scale (verbal aggression, anger and total score) and the time of AAS use. We discuss differences of AAS use between male and female bodybuilders and the screening of AAS use in the general population. Our findings highlight the importance of mental health awareness among people using AAS.
Disordered eating in sexual minority post‐9/11 United States veterans
Authors: Serier Kelsey N. , Smith Brian N. , Cooper Zafra , Vogt Dawne , Mitchell Karen S. 
Published: January 2022

AbstractObjectiveIt is well documented that sexual minority individuals are more likely to report disordered eating (DE) than those identifying as heterosexual. Although DE is prevalent in veterans, investigation of potential disparities in DE among sexual minority veterans is limited. This study examined rates of DE in post‐9/11 United States (U.S.) veterans identifying as sexual minorities and explored their association with discrimination because of marginalized identities.MethodsA national sample of recently separated post‐9/11 U.S. veterans were recruited. Women (N = 805; heterosexual [n = 656]; lesbian [n = 51]; bisexual [n = 98]) and men (N = 558; heterosexual [n = 540]; gay [n = 11]; bisexual [n = 7]) completed a survey assessing eating behaviors, mental health, and military experiences. Weighted correlational and regression analyses were conducted. Analyses in men were exploratory.ResultsDE was prevalent across gender and sexual orientation identity groups. Women identifying as bisexual and men identifying as gay reported higher rates of DE and consequent impairment compared to veterans who identified as heterosexual. There were no differences in DE between heterosexual and lesbian female veterans, but lesbian women reported lower DE‐related impairment. Experiencing any discrimination in the military was positively related to DE.DiscussionThis study found evidence of disparities in DE among sexual minority U.S. military veterans. While the factors contributing to these differences, such as the role of discrimination, are not completely understood, DE is a health concern for sexual minority veterans and requires continued investigation.Public significanceSexual minority individuals experience disparities in disordered eating; yet, this has not been explored in military veterans. This study found that disordered eating is a significant health concerns for veteran women and men, especially among those identifying as sexual minorities. More research is needed to explore why these disparities exist, such as the role of minority stress, in order to address the unique healthcare needs of these veterans.
Systemic lupus erythematosus patients contain B‐cell receptor repertoires sensitive to immunosuppressive drugs
Authors: Wu Meiyu , Pan Wenjing , Jia Chen , He Zhenghao , Zhao Ming , Tang Congli , Chang Christopher , Li Song , Wu Haijing , Lu Qianjin 
Published: January 2022

AbstractImmune repertoire (IR) during treatment may be a surrogate biomarker for disease response. Changes of the IR in systemic lupus erythematosus patients in response to immunosuppressive drugs were identified in ten SLE patients. Patients provided peripheral blood mononuclear cells at two time points for sequencing. They were divided into sensitive and nonsensitive groups by their clinical responses to immunosuppressive drugs. After treatment, the BCR expression significantly decreased in patients from the sensitive group while there was no change in patients from the nonsensitive group. IgM comprised a dominant portion of the BCR repertoire and increased slightly in all patients in the sensitive group but decreased in the nonsensitive group. IgA also exhibited opposing changes between the two groups. Shorter CDR3 of TRB and TRG chains occurred in the sensitive group. CDR3 length of IGK decreased significantly in the sensitive group. CDR3 of TCR δ/γ changed distinctly between time points in the sensitive group. Six immune‐related genes showed differential expression levels in sensitive and nonsensitive groups. Our study shows that it is BCR repertoire sensitivity to immunosuppressive drugs in SLE patients and sheds light on personalized therapy for SLE.