bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infantile hemangioma and cardiac defects: a puzzling association. A single center experience
Authors: Bassi Andrea , Azzarelli Andrea , Vaccaro Angelina , Mazzatenta Carlo 
Published: July 2022

BACKGROUND: Some studies have assessed the incidence of heart defects in children suffering from Infantile Hemangioma to be treated with propranolol, showing a possible higher prevalence of cardiac abnormalities in this group of patients.
METHODS: We retrospectively reviewed clinical charts of children with infantile haemangiomas referred to our Dermatologic division from 2016 to 2021, who underwent our pediatric cardiology protocol screening before starting propranolol therapy.
RESULTS: A total of 60 infants were enrolled. Electrocardiograms were available for all the patients and echocardiograpy for 50/60 (83.3%) children. Electrocardiogram didn’t reveal any alterations in the large majority of cases (pathologic in 2/60, 3.3%) while echocardiograms revealed findings in 31/50 (51.7%) patients. Of these, persistent foramen ovale, which was found in 14/50 patients (28%), was considered as non-pathologic. Interatrial septal defects were the main pathological finding in 15/50 patients (30%), as single defect or in association with other abnormalities.
CONCLUSION: Our study confirms the presence of a higher rate of cardiologic findings in patients with infantile hemangioma evaluated before starting oral propranolol, compared to the known rate of those defects in healthy newborns. We also confirm that interatrial septal defects are the most frequent pathologic finding with a higher prevalence compared to published studies. Large prospective studies are needed to clarify a possible association of pathological cardiac findings in all patients with infantile hemangiomas and thereafter to evaluated the possible effect of propranolol therapy on these defects during time.
Effect of Composite Flours of Finger Millet, Bambara Groundnut and ‘Khain’ (Lecaniodiscus Cupanioides) on Blood Glucose Response, Lipids, and Liver Enzymes of Alloxan-Induced Diabetic Rats
Authors: G. Ibrahim Doris , S. Asogwa Ifeyinwa , U. Onwurafor Eucheria , C. Ani Jane 
Published: July 2022

Aims: This study is aimed at determining the effect of composite flours of Finger millet (Fm), Bambara groundnut (BGN) and ‘Khain’ (Kh) (Lecaniodiscus cupanioides) on the blood glucose response, lipids and liver enzymes levels of alloxan-induced diabetic rats.
Study Design: The experiment was designed using one-way analysis of variance (ANOVA).
Place and Duration of Study: Department of Food Science and Technology and Department of Home Science Nutrition and Dietetics,University of Nigeria, Nsukka. Enugu State. May 2019 and July 2019
Methodology: Sixty rats were grouped into ten groups (six rats per group), housed individually in metabolic cages and were fed commercial rat chow for two weeks. After inducement with alloxan, eight groups of diabetic rats were fed with the composite flours [FK1 (95% Fm/5% Kh), FK2 (90% Fm/10% Kh), FB1K1 (95% [90% Fm/10% BGN]/5% Kh), FB1K2 (90% [90% Fm/10% BGN]/10% Kh), FB2K1 (95% [80% Fm/20%bBGN]/5% Kh), FB2K2 (90% [80% Fm/20% BGN]/10% Kh), FB3K1 (95% [70% Fm/30% BGN]/5% Kh), FB3K2 (90% [70% Fm/30% BGN]/10% Kh)] for four weeks while the two control (positive and negative) groups continued on commercial rat chow for four weeks also. The blood glucose response, blood lipids, total serum protein, albumin, urea, creatinine content, and liver enzymes were determined in the rats. The flours of Finger millet, Bambara groundnut and ‘Khain’ were analyzed for dietary fibre (DF) and phytochemical content.
Results: The total DF was higher (12.615 %) in finger millet and lower (5.375 %) in BGN. Khain had a value of 10.31 % total DF. Phenol content of samples ranged from 37.99 mg/100g for khain seed flour to 36.09 mg/100g in finger millet and tannin content of the samples ranged from 2.22 - 2.28 mg/100g. The diabetic rats groups fed with composite flours had significant (p<0.05) reduced blood glucose levels (60-86 %) compared to the positive control group (35 %), significantly reduced liver enzymes levels were observed in blood of diabetic rats groups fed with composite flours when compared to positive control group, diabetic rats groups fed with composite flours also showed weight loss, Total Cholesterol values of 149.62 – 235.3mg/dl, Triglycerides (97.96 – 153.72mg/dl), High Density Lipoprotein-Cholesterol (46.91 – 72.53mg/dl) and Low Density Lipoprotein-Cholesterol (73.45 – 153.38mg/dl) values. Urea and creatinine values of the diabetic rats groups fed with composite flours were within acceptable range.
Conclusion: The reduced blood glucose and liver enzymes levels in blood of diabetic rats fed with composite flours showed that composite flours of Finger millet, Bambara groundnut and ‘Khain’ have the potentials to be used as dietetics for the prevention and management of hyperglycemia.
Constraints in Cultivation of Medicinal Plants in Nagaur District of Rajasthan
Authors: Meghwal Shankar Lal 
Published: July 2022

The practice of growing herbs is a very ancient trend, and several studies have been conducted and are still being conducted in this field. It is terrible that we do not seem embarrassed to admit this, even when we are just beginning this practise. It is true that there has never been a complete standardisation of this agricultural certification. Herbs are a good option during this transitional time. It is imperative that you proceed with extreme caution if you plan to engage in agriculture. The present study deals with the problems and prospects in cultivation of Medicinal Plants. The study was conducted in Nagaur district of Rajasthan. A sample study of 11 villages out of ten tehsils of Nagaur district has been done. By selecting 11 sample villages from different tehsils of Nagaur district as primary sources, an attempt has been made to collect data and information and analyse various aspects of problems related to the cultivation of medicinal plants in the area. In the past years, the surprising changes in the general cropping pattern and the facts related to it have been studied and various dimensions of cultivation of medicinal plants have been studied considering tehsil wise level as the regional base unit. The problem of saline water, lack of surface water resources and problems in propagation of medicinal plants are the major problems faced by the farmers in the study area.
Multimodal treatment for the locally advanced stage IB, IIA, IIB patients of cervical cancer
Authors: Kim S.J. 
Published: July 2002

AbstractBy employing neoadjuvent chemotherapy (NCT) before radical hysterectomy (RS) and pelvic radiotherapy (RT) in bulky locally advanced cervical cancer (IB, IIA, IIB), the study was focused to update the results of the author's therapeutic experience with multimodal treatment by observing tumor free survivals along with related prognostic factors in different treatment modalities with NCT. The chemotherapy regimen for induction is composed of Vinblastin, Bleomycin and cis‐Platin regimen (VBP). The effect of neoadjuvent chemotherapy was evaluated by the WHO definition of clinical response (CR, PR, ST, PG). As a result of NCT study in the stage IA, IIA, and IIB cervical cancer patients recurrence occurred in 50 out of 138 patients (35.5%) treated with radical hysterectomy only (RS) compared with 17 out of 92 patients (18.5%) treated with NCT followed by radical surgery. In conjunction with the NCT study in the cervical cancer, another two groups of patients who were treated by neoadjuvent chemotherapy followed by radical hysterectomy (NCST) and adjuvent radiation (NCSRT) were evaluated in the high‐risk patients of cervical cancer with stage IB, IIA, and IIB. Primary responses in the NCST group (n = 61) were CR (68.9%), PR (22.9%), ST (4.9%) and PG (3.3%) respectively, while the chemoresponse of the NCSRT group (n = 101) were CR (65.3%), PR (18.9%), ST (4.9%) and PG (10.9%), respectively. The survival rates of the NCSRT group (n = 101) were 100% in all 1–5 years in CR group, while the rate of the NCST group was 100% at 1 year and 98.5% at 5 years in the CR group of patients. In contrast to CR, the patients who showed PR patients showed 40.1% of 5‐year survival rate in NCST group, and 12.6% in NCRST group. Tumor size, lymphnode metastasis and primary chemoresponse pattern were correlated to each other, but 5‐year survival rate of the CR group was much higher in the same stages IB, IIA and IIB of cervical cancer. In the multivariate analysis of known risk factors, the response pattern to primary chemotherapy, the responsiveness revealed the highest value (R.R. = 3.26) as a survival predictor in the patient treated with a multimodal approach.
Stable Genetic Transformation of EschscholziaCalifornica Expressing Synthetic Green Fluorescent Proteins
Authors: Lee Jintae , Pedersen Henrik 
Published: July 2002

AbstractAn efficient protocol is described for the stable genetic transformation of Eschscholzia californica (California poppy) using Agrobacterium tumefaciens as a vector. We have employed the disarmed A. tumefaciensLBA4404 encoding a synthetic green fluorescent protein reporter gene that is further controlled by an enhanced cauliflower mosaic virus 35S promoter. Stably transformed E. californica cells appear 3 weeks after initial cocultivation of A. tumefacienswith poppy leaves, stems, or roots. Transformed poppy calli were visualized by exposure to long‐wave UV or blue light and analyzed in detail by fluorescent microscopy and laser‐scanning microscopy. Moreover, green fluorescent calli have been maintained through continual subculture and grow well either on Gamborg's B5 agarose or liquid medium.
Treatment of High Strength Distillery Wastewater (Cherry Stillage) by Integrated Aerobic Biological Oxidation and Ozonation
Authors: Beltrán Fernando J. , Álvarez Pedro M. , Rodríguez Eva M. , García‐Araya Juan F. , Rivas Javier 
Published: July 2002

AbstractThe performance of integrated aerobic digestion and ozonation for the treatment of high strength distillery wastewater (i.e., cherry stillage) is reported. Experiments were conducted in laboratory batch systems operating in draw and fill mode. For the biological step, activated sludge from a municipal wastewater treatment facility was used as inoculum, showing a high degree of activity to distillery wastewater. Thus, BOD and COD overall conversions of 95% and 82% were achieved, respectively. However, polyphenol content and absorbance at 254 nm (A254) could not be reduced more than 35% and 15%, respectively, by means of single biological oxidation. By considering COD as substrate, the aerobic digestion process followed a Contois' model kinetics, from which the maximum specific growth rate of microorganisms (μmax) and the inhibition factor, β, were then evaluated at different conditions of temperature and pH. In the combined process, the effect of a post‐ozonation stage was studied. The main goals achieved by the ozonation step were the removal of polyphenols and A254. Therefore, ozonation was shown to be an appropriate technology to aid aerobic biological oxidation in the treatment of cherry stillage.
Enhanced Mixing and Mass Transfer in a Recirculation Loop Results in High Cell Densities in a Roller Bottle Reactor
Authors: Berson R. Eric , Pieczynski William J. , Svihla C. Kurt , Hanley Thomas R. 
Published: July 2002

AbstractA recirculation loop added to a large‐scale roller bottle reactor resulted in high cell densities as compared to standard roller bottles. Four different mammalian cell lines reached an average maximum density equal to 5.4 × 106 cells /mL (σ = 0.263), which was between 2.13 and 2.95 times greater than the densities in roller bottles without recirculation using the same cell lines. The high densities were maintained over long durations (>25 days) while the reactor operated with continuous perfusion. The increased densities are attributed to enhanced liquid mixing and oxygen transfer that occur as a result of the recirculation loop. Models were developed that describe axial liquid flow and oxygen transfer in both the sample loop and the reactor growth chamber. Axial dispersion and oxygen transfer coefficients are presented for a variety of operating conditions. The increased oxygen transfer characteristics of the reactor allow for easy scale‐up of roller bottle cultures by operating at larger volumes with greater liquid depths than conventional roller bottles permit. The surface‐area‐to‐volume ratio in the tests performed was 0.206 versus 1.16 cm−1 in a standard roller bottle.
The effects of polyvinyl chloride and polyolefin blood bags on red blood cells stored in a new additive solution
Authors: Hill H. R. , Oliver C. K. , Lippert L. E. , Greenwalt T. J. , Hess J. R. 
Published: July 2002

Background and ObjectivesRed blood cells (RBCs) must be stored in polyvinyl chloride (PVC) bags plasticized with di‐2‐ethylhexyl phthalate or a similar plasticizer to achieve their full storage life with conventional storage solutions. Improved storage solutions might remove this requirement and allow blood storage in other plastics. Experimental Additive Solution‐61 (EAS‐61), which maintains RBCs for 9 weeks with reduced haemolysis and satisfactory 51Cr 24‐h recovery, is an appropriate candidate improved RBC storage solution.Materials and MethodsTwenty‐four units of packed RBCs were pooled in groups of four units, each pool was realiquoted into four units and stored, six pooled units per arm, in one of the following: 100 ml of EAS‐61 in PVC; 200 ml of EAS‐61 in PVC; 100 ml of EAS‐61 in polyolefin (PO); and 200 ml of EAS‐61 in PO. Haemolysis, RBC morphology indices, RBC ATP concentrations, and other measures of RBC metabolism and function were measured weekly.ResultsRBC haemolysis exceeded 1% by 7 weeks in PO bags containing 100 ml or 200 ml of EAS‐61. In PVC bags, haemolysis was less than 1% at 11 weeks. RBC ATP concentrations were 1 mol/g of haemoglobin (Hb) higher at 2 weeks in the PVC‐stored units.ConclusionsRBCs stored in PVC had markedly less haemolysis and higher RBC ATP concentrations than those stored in PO. Haemolysis would limit RBC storage in PO bags to a duration of 6 weeks, even with EAS‐61.
Ionicity and electron molecular vibration interaction in mixed stack CT systems: M2P–TCNQ and M2P–TCNQF4
Authors: Meneghetti Moreno , Girlando Alberto , Pecile Cesare 
Published: July 2002

The powder Raman spectra and the polarized infrared absorption spectra of a polycrystalline oriented film of (1:1) CT complex of 5,10-dihydro-5,10-dimethylphenazine (M2P) with 7,7,8,8-tetracyanoquinodimethane (TCNQ) are reported together with the polarized reflectance infrared spectra of a mosaic of single crystals [(010) crystal face] and the conductivity spectra obtained from a Kramers–Krönig analysis of the reflectance data. The powder Raman and infrared spectra of M2P–TCNQF4 and their temperature dependence (300–15 K) are also presented. The M2P–TCNQ structure is known to be made up of donor–acceptor dimerized mixed stacks. The spectral features related to electron–molecular vibration (e–mv) interaction are successfully interpreted in terms of the dimer model, whose applicability is further validated after its first use in the case of the low temperature phase of tetrathiafulvalene–chloranil complex. The success is testified by the good
fit obtained between experimental and calculated vibronic features of the near and midinfrared spectra. The extracted values of the e–mv coupling constants of TCNQ moiety compare well with those obtained from other TCNQ complexes, whereas those of M2P are a first informative evaluation. The value of the degree of ionicity of M2P–TCNQ ( ρ=0.5±0.1) is obtained by completing the assignment of the spectra in terms of fundamental vibrational modes normally active under the molecular symmetry of the component molecules and by using carefully chosen diagnostic infrared frequencies. Results show that M2P–TCNQ is definitely one of the still rare cases of mixed stack CT complexes with intermediate ionicity. By using analogous criteria, the interpretation of room temperature and low temperature (15 K) spectra of M2P–TCNQF4 leads to the conclusion that for this complex ρ∼1.0. Its temperature dependent phase transition (T=120 K) between the room temperature regular mixed stack and the low temperature dimerized one is well characterized. The vibronic features appearing in the low-temperature infrared spectrum agree with predictions by the dimer model for a distorted stack. Consequently, it is likely that the phase transition is attributable to a dimerization of the stack due to a Spin–Peierls instability, in agreement with the previous indication given by magnetic susceptibility measurements.
The dielectric behavior of vapor-deposited amorphous solid water and of its crystalline forms
Authors: Johari G. P. , Hallbrucker Andreas , Mayer Erwin 
Published: July 2002

The dielectric permittivity and loss of vapor-deposited amorphous solid water (ASW) have been measured for fixed frequencies of 1 and 10 kHz from 80 K to its crystallization temperature. Similar measurements have also been made on the cubic ice formed after the crystallization of ASW and the hexagonal ice formed on heating the cubic ice. The loss tangent shows a broad sub-Tg relaxation peak centered at about 100 K and an approach towards a plateau value which appears as a shoulder. The peak is attributed to thermally activated rotation of H2O molecules with one or two dangling OH groups on the surface of the pores of the microporous sample, and the shoulder to localized motions within the network structure. Sintering of the samples on thermal cycling between 77 and ≊120 K in vacuo causes the broad peak to vanish. With increase in temperature, above Tg, the loss tangent shows the emergence of the expected α-relaxation peak of a liquid at T&gt;Tg, whose completion is terminated by the onset of crystallization to cubic ice at about the same temperature for 1 kHz and for 10 kHz measurements. Thereafter, crystallization becomes slower, thus allowing further observation of the low-temperature part of the α-relaxation peak.
The dielectric loss of amorphous solid water at 80 K is nearly 20 times that of the cubic ice formed on its crystallization after heating to 193 K, and nearly 3.5 times higher at Tg. The dielectric loss of the cubic ice formed on crystallization tends towards a plateau value prior to rapidly increasing with increase in temperature, an evidence for a low temperature relaxation which vanishes on conversion to hexagonal ice. This relaxation indicates a remnant topologically disordered structure of intergranular water and/or stacking faults in cubic ice. Samples sintered by thermal cycling in vacuo to ≊120 K crystallized in one step, whereas those without prior thermal cycling crystallized in two steps to cubic ice. Annealing of the ASW at 130 K completely removes the broad peak at ≊100 K and reduces the magnitude of the β-relaxation process. Partial crystallization of ASW completely removes the β-relaxation process, which indicates either preferential crystallization at the local regions of high mobility in the amorphous matrix or a change in the structure of the amorphous phase during crystallization.
On the N2–He potential energy surface
Authors: Beneventi L. , Casavecchia P. , Volpi G. G. , Wong C. C. K. , McCourt F. R. W. , Corey G. C. , Lemoine D. 
Published: July 2002

A detailed comparison of the predictive powers of two recently determined empirical and two recently proposed theoretical potential energy surfaces for the N2–He interaction has been carried out. In particular, the following properties have been tested: at the microscopic level, total and state-to-state differential cross sections and absolute total integral cross sections, while at the macroscopic level, interaction second virial, diffusion, viscosity, and thermal conductivity coefficients, as well as the rotational relaxation time, depolarized Rayleigh spectral collision broadening, and shear viscosity and thermal conductivity field-effect data in N2–He mixtures. Exact calculations have been employed, from the close-coupling method for treating scattering data at low energies to the classical trajectory method with second-order corrections to compute the effective cross sections that determine the bulk transport and relaxation phenomena.
The empirical exponential-spline–Morse-spline–van der Waals surface [J. Chem. Phys. 85, 7011 (1986)], closely followed by the model Bowers–Tang–Toennies surface [J. Chem. Phys. 88, 5465 (1988)], gives better simultaneous agreement with the scattering data, the second virial coefficient data, the bulk transport data, and the depolarized Rayleigh collision-broadening data, which are properties sensitive to the spherical component of the interaction and to the anisotropy of the low repulsive wall. None of the potential surfaces examined here includes a dependence upon the vibrational stretching coordinate of the N2 molecule, since none of the data employed in the fitting is sensitive to this coordinate. The two theoretical model potentials, especially that based upon an earlier Hartree–Fock plus damped dispersion model surface [J. Phys. Chem. 88, 2036 (1984)], gives better agreement with the rotational relaxation and field-effect data, which are properties sensitive to the anisotropy of the high-repulsive wall. It is established that the exponential-spline–Morse-spline–van der Waals and Bowers–Tang–Toennies surfaces are on the whole the more reliable of the empirical and model surfaces examined, respectively. It is concluded that the optimum N2–He potential energy surface should be a blend of the empirical exponential-spline–Morse-spline–van der Waals and of the two model surfaces.
Muonium reaction kinetics with the hydrogen halide gases
Authors: Gonzalez Alicia C. , Tempelmann Alexandra , Arseneau Donald J. , Fleming Donald G. , Senba Masayoshi , Kempton James R. , Pan James J. 
Published: July 2002

The reaction rates of the muonium (Mu) atom with HBr and HI in ∼1 atm N2 moderator have been measured over the temperature range 160–490 K using the μSR technique. While both abstraction and exchange reactions are possible, only the abstraction reaction should be observable, being moderately exothermic. Comparisons with the corresponding H(D) reactions reveal small kinetic isotope effects in both reactions, which do not vary strongly with temperature (kMu/kH≊3.5 near 300 K), consistent with the (classical) ratio of mean velocities. Surprisingly, quantum tunneling, normally facile for similarly exothermic reactions of the ultralight Mu atom (mMu/mH≊1/9), appears to be of little importance here. This despite the fact that the (temperature-independent) experimental activation energies are much less than the expected vibrationally adiabatic barrier heights (estimated to be ≊1.5 kcal mol−1) and, particularly in the case of Mu+HI, much less than the corresponding H-atom activation energy: 0.13±0.03 vs 0.70±0.3 kcal mol−1. In the case of reactions with HBr, the experimental Mu- and H-atom activation energies are much more similar: 0.51±0.03 and 0.74±0.12 kcal mol−1, respectively, over comparable temperature ranges. These data pose a conundrum in which several compensating effects related to the much lighter Mu-atom mass seem to be involved. Theoretical calculations are urgently required.
In our view the topography of the potential-energy surface(s) for H2X is poorly known, particularly in the region of the barrier. It may be that the abstraction barriers for both Mu+HI and Mu+HBr are considerably later and even smaller than current calculations indicate, resulting in a cancellation of the effects of zero-point-energy shifts and quantum tunneling at the transition state. Differences in skewing angles between Mu and H+HX could favor a shorter tunneling path for the H-atom reaction, possibly compensating for its heavier mass. Steric or rebound effects from ‘‘bottlenecks’’ on the (mass-weighted) potential surfaces for Mu reactivity may also play some role. An upper limit for the 300 K reaction rate of Mu+HCl is given as well. In contrast to both HBr and HI, this reaction is quite endothermic and hence exhibits an inverse kinetic isotope effect (kMu≪kH).