bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slowdown in Landfalling Tropical Cyclone Motion in South China
Authors: Wu Kun , Wang Chao , Wu Liguang , Zhao Haikun , Cao Jian 
Published: November 2022

AbstractChina is one of the countries suffering the most tropical cyclone (TC) disasters, while changes in translation speed of TCs landfalling in China remain unclear. Here we found that the translation speed of landfalling TCs in south China during the boreal summer has significantly decreased by 0.3 m s−1decade−1 during 1979–2019, which is largely driven by a decadal deceleration in steering flow in the late 1990s. The slowdown in steering flow is found to be a balance of the opposite effects of the negative phase of the Pacific Decadal Oscillation and sea surface temperature (SST) warming in the Indian Ocean since the late 1990s. Given the recent Indian Ocean SST warming has been viewed as a footprint of external forcing, the results suggest that the effects of external forcing and natural variability on TC translation speed can offset each other.
An Interannual Drought Feedback Loop Affects the Surface Energy Balance and Cloud Properties
Authors: Hartick Carl , Furusho‐Percot Carina , Clark Martyn P. , Kollet Stefan 
Published: November 2022

AbstractLong‐term groundwater droughts are known to persist over timescales from multiple years up to decades. The mechanisms leading to drought persistence are, however, only partly understood. Applying a unique terrestrial system modeling platform in a probabilistic simulation framework over Europe, we discovered an important positive feedback mechanism from groundwater into the atmosphere that may increase drought persistence at interannual time scales over large continental regions. In the feedback loop, groundwater drought systematically increases net solar radiation via a cloud feedback, which, in turn, increases the drying of the land. In commonly applied climate and Earth system models, this feedback cannot be simulated due to a lack of groundwater memory effects in the representation of terrestrial hydrology. Thus, drought persistence and compound events may be underestimated in current climate projections.
Changes in Deep Ocean Contribute to a “See‐Sawing” Gulf Stream Path
Authors: Wang Zeliang , Yang Jiayan , Johnson Catherine , DeTracey Brendan 
Published: November 2022

AbstractThis study demonstrates that a decrease of the water‐mass density below 1,000 m has led to a pattern of see‐saw shift in the Gulf Stream (GS) position between 74 and 50°W in longitude during 1993–2017, with the New England Seamounts as the pivot point. The GS moved northward in the upstream region and shifted southward in the downstream. Our empirical orthogonal function analyses of satellite altimeter data demonstrate that the second mode (EOF2) represents changes in the GS strength and therefore can be used as an index for the Atlantic Meridional Overturning Circulation. Decreasing water density below 1,000 m is also the principal mechanism driving the weakening of the GS.
Bathymetric Prediction Using Multisource Gravity Data Derived From a Parallel Linked BP Neural Network
Authors: Sun Heyuan , Feng Yikai , Fu Yanguang , Sun Weikang , Peng Cong , Zhou Xinghua , Zhou Dongxu 
Published: November 2022

AbstractGravity anomalies (GAs) and vertical gravity gradient anomalies (VGGs) are regularly used to predict bathymetry. However, few studies have explored the combination of the GAs and VGGs to predict bathymetry. We introduce the back propagation (BP) neural network into bathymetric prediction field and propose a method to predict depth from GAs and VGGs. The method was tested in the Mariana Trench region, and a neural network bathymetry model was constructed using feature data obtained from GAs and VGGs as the input of the BP neural network. Additionally, single‐beam sounding data were used as label data. By comparing the neural network and the gravity‐geologic method (GGM), the neural network was found to provide better performance with an accuracy improvement of 19%. The root‐mean‐square of the absolute difference between the neural network bathymetry model and the single‐beam sounding data was 72.40 m, with a relative accuracy of 1.71%. Approximately 50% of the differences were distributed within ±20 m, and 90% were distributed within ±100 m. The neural network bathymetry model was also compared with the GGM bathymetry model for different depths and topographies, and the results verified the feasibility and effectiveness of the BP neural network method.
Remote Aerosol Simulated During the Atmospheric Tomography (ATom) Campaign and Implications for Aerosol Lifetime
Authors: Gao Chloe Yuchao , Heald Colette L. , Katich Joseph M. , Luo Gan , Yu Fangqun 
Published: November 2022

AbstractWe investigate and assess how well a global chemical transport model (GEOS‐Chem) simulates submicron aerosol mass concentrations in the remote troposphere. The simulated speciated aerosol (organic aerosol (OA), black carbon, sulfate, nitrate, and ammonium) mass concentrations are evaluated against airborne observations made during all four seasons of the NASA Atmospheric Tomography Mission (ATom) deployments over the remote Pacific and Atlantic Oceans. Such measurements over pristine environments offer fresh insights into the spatial (Northern [NH] and Southern Hemispheres [SH], Atlantic, and Pacific Oceans) and temporal (all seasons) variability in aerosol composition and lifetime, away from continental sources. The model captures the dominance of fine OA and sulfate aerosol mass concentrations in all seasons. There is a high bias across all species in the ATom‐2 (NH winter) simulations; implementing recent updates to the wet scavenging parameterization improves our simulations, eliminating the large ATom‐2 (NH winter) bias, improving the ATom‐1 (NH summer) and ATom‐3 (NH fall) simulations, but producing a model underestimate in aerosol mass concentrations for the ATom‐4 (NH spring) simulations. Following the wet scavenging updates, simulated global annual mean aerosol lifetimes vary from 1.9 to 4.0 days, depending on species. Aerosol lifetimes in each hemisphere vary by season, and are longest for carbonaceous aerosol during the southern hemispheric fire season. The updated wet scavenging parameterization brings simulated concentrations closer to observations and reduces global aerosol lifetime for all species, indicating the sensitivity of global aerosol lifetime and burden to wet removal processes.
Non‐Equilibrium Fractionation Factors for D/H and 18O/16O During Oceanic Evaporation in the North‐West Atlantic Region
Authors: Zannoni D. , Steen‐Larsen H. C. , Peters A. J. , Wahl S. , Sodemann H. , Sveinbjörnsdóttir A. E. 
Published: November 2022

AbstractOcean isotopic evaporation models, such as the Craig‐Gordon model, rely on the description of nonequilibrium fractionation factors that are, in general, poorly constrained. To date, only a few gradient‐diffusion type measurements have been performed in ocean settings to test the validity of the commonly used parametrization of nonequilibrium isotopic fractionation during ocean evaporation. In this work, we present 6 months of water vapor isotopic observations collected from a meteorological tower located in the northwest Atlantic Ocean (Bermuda) with the objective of estimating nonequilibrium fractionation factors (k, ‰) for ocean evaporation and their wind speed dependency. The Keeling Plot method and Craig‐Gordon model combination were sensitive enough to resolve nonequilibrium fractionation factors during evaporation resulting into mean values of k18 = 5.2 ± 0.6‰ and k2 = 4.3 ± 3.4‰. Furthermore, we evaluate the relationship between k and 10‐m wind speed over the ocean. Such a relationship is expected from current evaporation theory and from laboratory experiments made in the 1970s, but observational evidence is lacking. We show that (a) in the observed wind speed range [0–10 m s−1], the sensitivity of k to wind speed is small, in the order of −0.2‰ m−1 s for k18, and (b) there is no empirical evidence for the presence of a discontinuity between smooth and rough wind speed regime during isotopic fractionation, as proposed in earlier studies. The water vapor d‐excess variability predicted under the closure assumption using the k values estimated in this study is in agreement with observations over the Atlantic Ocean.
Mars 2020 Perseverance Rover Studies of the Martian Atmosphere Over Jezero From Pressure Measurements
Authors: Sánchez‐Lavega A. , del Rio‐Gaztelurrutia T. , Hueso R. , Juárez M. de la Torre , Martínez G. M. , Harri A.‐M. , Genzer M. , Hieta M. , Polkko J. , Rodríguez‐Manfredi J. A. , Lemmon M. T. , Pla‐García J. , Toledo D. , Vicente‐Retortillo A. , Viúdez‐Moreiras D. , Munguira A. , Tamppari L. K. , Newman C. , Gómez‐Elvira J. , Guzewich S. , Bertrand T. , Apéstigue V. , Arruego I. , Wolff M. , Banfield D. , Jaakonaho I. , Mäkinen T. 
Published: November 2022

AbstractThe pressure sensors on Mars rover Perseverance measure the pressure field in the Jezero crater on regular hourly basis starting in sol 15 after landing. The present study extends up to sol 460 encompassing the range of solar longitudes from Ls ∼ 13°–241° (Martian Year (MY) 36). The data show the changing daily pressure cycle, the sol‐to‐sol seasonal evolution of the mean pressure field driven by the CO2 sublimation and deposition cycle at the poles, the characterization of up to six components of the atmospheric tides and their relationship to dust content in the atmosphere. They also show the presence of wave disturbances with periods 2–5 sols, exploring their baroclinic nature, short period oscillations (mainly at night‐time) in the range 8–24 min that we interpret as internal gravity waves, transient pressure drops with duration ∼1–150 s produced by vortices, and rapid turbulent fluctuations. We also analyze the effects on pressure measurements produced by a regional dust storm over Jezero at Ls ∼ 155°.
Linear Inversion of Fluvial Topography in the Northern Apennines: Comparison of Base‐Level Fall to Crustal Shortening
Authors: Fisher J. A. , Pazzaglia F. J. , Anastasio D. J. , Gallen S. F. 
Published: November 2022

AbstractFluvial terraces, longitudinal river profiles, and growth strata carry comparable records of the deformation history in tectonically active mountain belts. In the northern Apennines, these markers are preserved across an actively uplifting, steep mountain front. We take advantage of this setting to model base‐level fall histories reconstructed from a linear inversion of fluvial topography on six transverse catchments spanning 110 km along the strike from Bologna to Parma. We compare these histories to records of crustal shortening preserved in growth strata. The fluvial inversion model is based on the detachment‐limited stream‐power model and considers the variable erodibility of bedrock lithology. Uplift is assumed to be spatially uniform at the catchment scale and crudely in balance with long‐term 10Be terrestrial cosmogenic nuclide (TCN) erosion rates that range from ∼0.3 to 0.7 mm yr−1. The model predicts rates of base‐level fall that are comparable with published rates of fault slip from growth strata and incision from terrace deposits. The modeling demonstrates how orogenic shortening and topographic growth are nonuniform and partitioned along the strike of the Apennine mountain front. Rivers record steady uplift in the last ∼1 Myrs, temporally coincident with overfilling of the Po Plain and reduction of shallow fault slip, supporting a proposed switch from thin‐to thick‐skinned crustal shortening. These results are a novel example of base‐level fall records assembled from both the erosional source and depositional sink and highlight the versatility and challenges of fluvial inversion modeling.
The diverse repertoire of ISG15: more intricate than initially thought
Authors: Kang Ji An , Kim Yoon Jung , Jeon Young Joo 
Published: November 2022

AbstractISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular molecule but also as a post-translational modifier in the process of ISG15 conjugation (ISGylation). ISG15 has only been identified in vertebrates, indicating that the functions of ISG15 and its conjugation are restricted to higher eukaryotes and have evolved with IFN signaling. Despite the highlighted complexity of ISG15 and ISGylation, it has been suggested that ISG15 and ISGylation profoundly impact a variety of cellular processes, including protein translation, autophagy, exosome secretion, cytokine secretion, cytoskeleton dynamics, DNA damage response, telomere shortening, and immune modulation, which emphasizes the necessity of reassessing ISG15 and ISGylation. However, the underlying mechanisms and molecular consequences of ISG15 and ISGylation remain poorly defined, largely due to a lack of knowledge on the ISG15 target repertoire. In this review, we provide a comprehensive overview of the mechanistic understanding and molecular consequences of ISG15 and ISGylation. We also highlight new insights into the roles of ISG15 and ISGylation not only in physiology but also in the pathogenesis of various human diseases, especially in cancer, which could contribute to therapeutic intervention in human diseases.
Milliwatt terahertz harmonic generation from topological insulator metamaterials
Authors: Tielrooij Klaas-Jan , Principi Alessandro , Reig David Saleta , Block Alexander , Varghese Sebin , Schreyeck Steffen , Brunner Karl , Karczewski Grzegorz , Ilyakov Igor , Ponomaryov Oleksiy , de Oliveira Thales V. A. G. , Chen Min , Deinert Jan-Christoph , Carbonell Carmen Gomez , Valenzuela Sergio O. , Molenkamp Laurens W. , Kiessling Tobias , Astakhov Georgy V. , Kovalev Sergey 
Published: November 2022

AbstractAchieving efficient, high-power harmonic generation in the terahertz spectral domain has technological applications, for example, in sixth generation (6G) communication networks. Massless Dirac fermions possess extremely large terahertz nonlinear susceptibilities and harmonic conversion efficiencies. However, the observed maximum generated harmonic power is limited, because of saturation effects at increasing incident powers, as shown recently for graphene. Here, we demonstrate room-temperature terahertz harmonic generation in a Bi2Se3 topological insulator and topological-insulator-grating metamaterial structures with surface-selective terahertz field enhancement. We obtain a third-harmonic power approaching the milliwatt range for an incident power of 75 mW—an improvement by two orders of magnitude compared to a benchmarked graphene sample. We establish a framework in which this exceptional performance is the result of thermodynamic harmonic generation by the massless topological surface states, benefiting from ultrafast dissipation of electronic heat via surface-bulk Coulomb interactions. These results are an important step towards on-chip terahertz (opto)electronic applications.
Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1
Authors: Huang Chaoqing , Wang Yuan 
Published: November 2022

AbstractOsteoporosis (OP) tends to occur in postmenopausal women, making them prone to fractures. N6-methyladenosine (m6A) methylation plays a crucial role in OP. Herein, we aimed to explore the effects of METTL14 on osteogenesis and the underlying mechanism. Osteogenic differentiation was assessed through osteoblast markers expression, cell proliferation, ALP activity, and mineralization, which were detected by qRT-PCR, CCK-8, EdU assay, ALP staining assay, and ARS staining assay, respectively. Osteoporosis was evaluated in OVX mice using qRT-PCR, microcomputed tomography, and H&E staining assay. The levels of METTL14 and SMAD1 were measured using qRT-PCR and western blot, and their interaction was assessed using RIP and luciferase reporter assay. M6A methylation was analyzed using the Me-RIP assay. The results indicated that m6A, METTL14, and SMAD1 levels were downregulated in patients with OP and OVX mice, and upregulated in osteogenic BMSCs. Knockdown of METTL14 suppressed osteogenesis of BMSCs and reduced bone mass of OVX mice. Moreover, silencing of METTL14 positively related to SMAD1 and inhibited m6A modification of SMAD1 by suppressing its stability. IGF2BP1 was identified as the methylation reader, and which knockdown reversed the upregulation induced by SMAD1. Overexpression of SMAD1 reversed the suppression of osteogenic differentiation induced by METTL14 knockdown. In conclusion, interference with METTL14 inhibited osteogenic differentiation of BSMCs by m6A modification of SMAD1 in an IGFBP1 manner, suggesting that METTL14 might be a novel approach for improving osteoporosis.
USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling
Authors: Huang Wen-ya , Liao Zhi-bin , Zhang Jia-cheng , Zhang Xin , Zhang Hong-wei , Liang Hui-fang , Zhang Zun-yi , Yang Tao , Yu Jia , Dong Ke-shuai 
Published: November 2022

AbstractThioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in mammalian cells, which has been reported to be involved in tumorigenesis. However, its roles and regulatory mechanism underlying the progression of HCC remains poorly understood. In this study, we demonstrated that TXNRD1 was significantly upregulated in HCC tumor tissues and correlated with poor survival in HCC patients. Functional studies indicated TXNRD1 knockdown substantially suppressed HCC cell proliferation and metastasis both in vitro and in vivo, and its overexpression showed opposite effects. Mechanistically, TXNRD1 attenuated the interaction between Trx1 and PTEN which resulting in acceleration of PTEN degradation, thereby activated Akt/mTOR signaling and its target genes which conferred to elevated HCC cell mobility and metastasis. Moreover, USF2 was identified as a transcriptional suppressor of TXNRD1, which directly interacted with two E-box sites in TXNRD1 promoter. USF2 functioned as tumor suppressor through the downstream repression of TXNRD1. Further clinical data revealed negative co-expression correlations between USF2 and TXNRD1. In conclusion, our findings reveal that USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling.
Field measurements reveal exposure risk to microplastic ingestion by filter-feeding megafauna
Authors: Kahane-Rapport S. R. , Czapanskiy M. F. , Fahlbusch J. A. , Friedlaender A. S. , Calambokidis J. , Hazen E. L. , Goldbogen J. A. , Savoca M. S. 
Published: November 2022

AbstractMicroparticles, such as microplastics and microfibers, are ubiquitous in marine food webs. Filter-feeding megafauna may be at extreme risk of exposure to microplastics, but neither the amount nor pathway of microplastic ingestion are well understood. Here, we combine depth-integrated microplastic data from the California Current Ecosystem with high-resolution foraging measurements from 191 tag deployments on blue, fin, and humpback whales to quantify plastic ingestion rates and routes of exposure. We find that baleen whales predominantly feed at depths of 50–250 m, coinciding with the highest measured microplastic concentrations in the pelagic ecosystem. Nearly all (99%) microplastic ingestion is predicted to occur via trophic transfer. We predict that fish-feeding whales are less exposed to microplastic ingestion than krill-feeding whales. Per day, a krill-obligate blue whale may ingest 10 million pieces of microplastic, while a fish-feeding humpback whale likely ingests 200,000 pieces of microplastic. For species struggling to recover from historical whaling alongside other anthropogenic pressures, our findings suggest that the cumulative impacts of multiple stressors require further attention.
Unequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA
Authors: Kodros John K. , Bell Michelle L. , Dominici Francesca , L’Orange Christian , Godri Pollitt Krystal J. , Weichenthal Scott , Wu Xiao , Volckens John 
Published: November 2022

AbstractPersons of color have been exposed to a disproportionate burden of air pollution across the United States for decades. Yet, the inequality in exposure to known toxic elements of air pollution is unclear. Here, we find that populations living in racially segregated communities are exposed to a form of fine particulate matter with over three times higher mass proportions of known toxic and carcinogenic metals. While concentrations of total fine particulate matter are two times higher in racially segregated communities, concentrations of metals from anthropogenic sources are nearly ten times higher. Populations living in racially segregated communities have been disproportionately exposed to these environmental stressors throughout the past decade. We find evidence, however, that these disproportionate exposures may be abated though targeted regulatory action. For example, recent regulations on marine fuel oil not only reduced vanadium concentrations in coastal cities, but also sharply lessened differences in vanadium exposure by segregation.
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
Authors: Mitchell Allison V. , Wu Ling , James Block C. , Zhang Mu , Hackett Justin , Craig Douglas B. , Chen Wei , Zhao Yongzhong , Zhang Bin , Dang Yongjun , Zhang Xiaohong , Zhang Shengping , Wang Chuangui , Gibson Heather , Pile Lori A. , Kidder Benjamin , Matherly Larry , Yang Zhe , Dou Yali , Wu Guojun 
Published: November 2022

AbstractAberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism of epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting the MLL/KMT2 histone methyltransferase complex as a transcriptional coactivator. We first establish that FOXQ1 promoter recognition precedes MLL complex assembly and histone-3 lysine-4 trimethylation within the promoter regions of critical genes in the EMT program. Mechanistically, we identify that the Forkhead box in FOXQ1 functions as a transactivation domain directly binding the MLL core complex subunit RbBP5 without interrupting FOXQ1 DNA binding activity. Moreover, genetic disruption of the FOXQ1-RbBP5 interaction or pharmacologic targeting of KMT2/MLL recruitment inhibits FOXQ1-dependent gene expression, EMT, and in vivo tumor progression. Our study suggests that targeting the FOXQ1-MLL epigenetic axis could be a promising strategy to combat triple-negative breast cancer metastatic progression.
Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L
Authors: Zhu Cuige , Iwase Mari , Li Ziqian , Wang Faliang , Quinet Annabel , Vindigni Alessandro , Shao Jieya 
Published: November 2022

AbstractDNA replication forks are tightly controlled by a large protein network consisting of well-known core regulators and many accessory factors which remain functionally undefined. In this study, we report previously unknown nuclear functions of the actin-binding factor profilin-1 (PFN1) in DNA replication, which occur in a context-dependent fashion and require its binding to poly-L-proline (PLP)-containing proteins instead of actin. In unperturbed cells, PFN1 increases DNA replication initiation and accelerates fork progression by binding and stimulating the PLP-containing nucleosome remodeler SNF2H. Under replication stress, PFN1/SNF2H increases fork stalling and functionally collaborates with fork reversal enzymes to enable the over-resection of unprotected forks. In addition, PFN1 binds and functionally attenuates the PLP-containing fork protector BODL1 to increase the resection of a subset of stressed forks. Accordingly, raising nuclear PFN1 level decreases genome stability and cell survival during replication stress. Thus, PFN1 is a multi-functional regulator of DNA replication with exploitable anticancer potential.