bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five-year kidney functional change from the new baseline kidney function after partial nephrectomy in patients with clinical T1 renal tumors
Authors: Takagi Toshio , Yoshida Kazuhiko , Ikeda Takashi , Kondo Tsunenori , Fukuda Hironori , Ishihara Hiroki , Kobayashi Hirohito , Iizuka Junpei , Omae Kenji , Tanabe Kazunari , Ishida Hideki 
Published: April 2022

Abstract
Background: To investigate subsequent renal function from the new baseline in patietns who underwent partial nephrectomy (PN) for renal tumors, and analyze factors associated with the renal functional change.Methods: This study included 466 patients who underwent PN for stage 1 kidney tumors and were regularly followed up for at least 5 years. The new baseline kidney function was defined as eGFR at 6 months after surgery. Kidney function was evaluated at every year for five years after surgery, and kidney function change was calculated as eGFR at 6 months after surgery-eGFR at each year after surgery/eGFR at 6 months after surgery × 100 (%). Factors associated with kidney functional change were evaluated with multivariate cox regression analysis.Results: The median age of patients was 60 years, and 76% of them were male. The median preoperative eGFR was 68 ml/min/1.73m2, and 35% and 14% of the patients had hyptertension and diabetes mellitus (DM), respectively. The new baseline eGFR was 61 ml/min/1.73m2. The mean kidney function change from the new baseline was -0.7% at one year, -1.1% at two years, -2.7% at three years, -3.8% at four years, and -5.4% at five years. Multivariate analysis showed that DM, preoperative lower eGFR and high complexity tumors were significantly associated with decreased kidney function from baseline to five years after surgery.Conclusions: Kidney function sequentialy decreased from the new baseline after PN. DM, lower preoperative eGFR and high complexity tumor were independent predictors for deterioration of eGFR from the new baseline to 5 years postoperatively.
How does fracture treatment affect patients? Universal scoring of treatment outcome by using the FRESH- score
Authors: Frese Jasper , Beuge Carolin , Rau Yannick , Schulz Arndt-Peter , Wendlandt Robert 
Published: April 2022

Abstract
PurposeAs part of a fracture treatment registry, a questionnaire was developed to record the general state of health of the patients, the result of fracture treatment and complications. This resulted in the "Fracture Evaluation Since Hospitalization" score, or FRESH- score. The development and validation of the FRESH- score is the subject of this manuscript. MethodsFor validation, the EQ-5D-5L was used as a matching questionnaire. 237 patients were contacted via mail and received both questionnaires. The reliability was determined testing the internal consistency by Cronbach's alpha, convergent validity was tested with the Pearson correlation, construct validity was determined using the Wilcoxon rank sum test, as well as the paired t-test.ResultsCronbach's alpha for reliability was moderate at 0.57. Convergent validity using Pearson's correlation resulted in a moderate correlation with a coefficient of 0.41. Construct validity was determined using the Wilcoxon rank sum test, as well as the paired t-test. Both methods showed a high significance of p=0.0287 and a tendency p=0.0677, which represents a relationship between the two samples. Content validity was tested using missing values, which were low at 8% on average.ConclusionThe FRESH- score proved to be reasonable, reliable and sufficiently valid. Application with a larger samples would strengthen the validity of the questionnaire. The score fills a gap between existing questionnaires in orthopedics. An advantage of the FRESH- score is its concise set up and broad applicability.
Association of dietary Eicosapentaenoic acid (EPA) &amp; Docosahexaenoic acid (DHA) and marker of oxidative stress, superoxide dismutase (SOD) in obese women athletes: A cross-sectional study
Authors: Tavasoli Parastoo , Gholizadeh Mohammad , Alaeddini Farshid , Ghiasvand Reza , Amini Pegah 
Published: April 2022

Abstract
Background: omega 3 fatty acid metabolites (Eicosapentaenoic acid and Docosahexaenoic acid) are essential fatty acids which showed significant roles for making balance on inflammatory and oxidative stress markers. The aim of present study is to investigate the correlation of dietary EPA/DHA with some of the biochemical markers of oxidative stress such as SOD, hs-CRP, and BMI. Method: this study used to on women people with mean ages 37.81± 7.65. The women are overweight and obese with mean of BMI with mean ± SD 29 ± 3.8. Demographic data of people by filling a form. Weight was assessed by Seca scale and CRP, SOD and Adiponectin of people were measured by obtaining blood from people. Results. There is observed significant association between EPA and SOD in crude model, although this correlation no observed after adjusting potential cofounder including fat, energy intake, BMI, Caffeine Consumption and education with β ± SE (1.29, p-value<0.047 and 0.07, p-value: 0.43). Moreover, there is not observed significant association between EPA and CRP with β ± SE (0.001, p-value=0.634 and -0.09, p-value: 0.76) as well as between EPA and Adiponectin with β ± SE (0.0001, p-value=0.632 and -0.02, p-value: 0.84), respectively. Whereas, it was demonstrated significant association between DHA and SOD in crude model, although this correlation no observed after adjusting potential cofounder including fat, energy intake, BMI, Caffeine Consumption and education with β ± SE (3.38, p-value<0.047 and -0.20, p-value: 0.40). Moreover, there is not observed significant association between EPA and CRP with β ± SE (-0.003, p-value=0.689 and -0.07, p-value: 0.75) as well as between EPA and Adiponectin with β ± SE (0.001, p-value=0.617 and 0.05, p-value: 0.85), respectively.ConclusionOur study showed significant association between EPA and DHA and SOD before adjusting potential cofounder, nevertheless did not show a significant association between DHA and EPA and CRP, Adiponectin and SOD plasma concentration.
Topographic factors drive natural understory revegetation in burned areas
Authors: Zhixue He , Lei Wang , Luo Jun , Bin Zhang , Qingchun Deng , Hui Liu , Haiqing Yang 
Published: April 2022

Abstract
Background: In nature, fire is an important disturbance in forest ecosystems and has important impacts on vegetation succession. To reveal the characteristics of natural understory revegetation after burning and its response to environmental factors, we studied burned areas in a subtropical climate (Xide County, China). Results: Based on quadrat surveys and correlation analyses, the main results of this study were as follows. (1) Within four months after a fire, 71 species, 52 genera, and 20 families gained, representing rapid recoveryafter a fire. (2) The Shannon-Wiener, Simpson, and Margalef indexes increased with recovery, whereas the Pielou index decreased; the Margalef index was the most sensitive, increasing by 5.44 and 5.16 in lightly and severely burned areas, respectively. (3) The community stability was relatively low at the initial stage of revegetation andtended to increase with the intensity of the fire. (4) Elevation and slope were the main physical factors affecting the biodiversity indexes and distribution. Conclusions: This study could help us to understand the relationships between revegetation and topographic factors in burned areas, thereby providing a scientific basis for related ecological restoration.
Achievements and challenges in the development of a respectful delivery care model provided by Partners in Health in rural Mexico: A mixed methods analysis
Authors: Nigenda Gustavo , Montaño Mariana , Aranda Zeus , Aristizabal Patricia , Ortiz Fabiola , Ortega Soraya , Juárez Ameyalli , Macías Valeria , Zárate-Grajales Rosa Amarilis , Flores Hugo 
Published: April 2022

Abstract
As with many low- and middle-income countries, Mexico has developed and implemented a model of obstetric care centered on the biomedical clinical tradition, with important achievements and enormous challenges. In recent years, the federal Ministry of Health of Mexico decided to promote alternative models through changes in legislation and financing for the care of rural populations living in deprived areas. Objective: Analyzing the implementation of a model of respectful delivery care by supervised nursing and midwifery undergraduate interns in a birthing center in the State of Chiapas, operated by a civil society organization in collaboration with the state health authority and educational institutions, in order to identify achievements and challenges ahead. Methods: We used information from various primary and secondary sources and undertook a mixed-methods analysis. Results: The proportion of births attended in the birthing center increased in relation to all the births attended in public institutions of Ángel Albino Corzo between 2017 and 2020. Overall, there was an increase in positive indicators of respectful care with the implemented model, while the negative indicators decreased. The service demonstrated high levels of satisfaction and increased demand in the local population. Between 2016 and 2020, obstetrician nurses attended 800 deliveries with no maternal deaths and managed some emergency cases referred to specialized care. Conclusions: The case illustrates the great potential of alternative delivery care models to the medicalized model that is often predominant. Therefore, evidence-based midwife and nurse-led models of obstetric clinical care are suitable models of care.
Long-term outcomes of endoscopic transpapillary gallbladder drainage using a novel spiral plastic stent in acute calculus cholecystitis
Authors: Sato Junya , Nakahara Kazunari , Michikawa Yosuke , Suetani Keigo , Igarashi Yosuke , Sekine Akihiro , Satta Yusuke , Kobayashi Shinjiro , Otsubo Takehito , Tateishi Keisuke 
Published: April 2022

Abstract
Background: Endoscopic transpapillary gallbladder stenting (EGBS) is considered for patients with contraindications to early surgery for acute calculus cholecystitis. However, evidence regarding the long-term outcomes of EGBS is insufficient to date. Aims: To evaluate the feasibility of EGBS as a bridge to or alternative to surgery when there are contraindications, we retrospectively evaluated the long-term outcomes of EGBS using a novel spiral-shaped plastic stent.Patients and methods: We reviewed the cases of patients who underwent EGBS using a novel spiral-shaped plastic stent for acute calculus cholecystitis between January 2011 and December 2019.Results: Forty-nine patients were included. The clinical success rate of EGBS was 97%. After EGBS, 25 patients (surgery group) underwent elective cholecystectomy and 24 patients did not (follow-up group). In the surgery group, the median period from EGBS to surgery was 93 days. There was a single late adverse event with cholecystitis recurrence. In the follow-up group, the median follow-up period was 236 days. Late adverse events were observed in seven patients, including recurrence of cholecystitis (four patients), duodenal penetration by the distal stent end (two patients), and distal stent migration without cholecystitis (one patient). In the follow-up group, the time to recurrence of biliary obstruction was 527 days.Conclusions: EGBS with a novel spiral-shaped plastic stent is safe and effective for long-term acute calculus cholecystitis. EGBS may be a bridge to surgery and a surgical alternative for acute calculus cholecystitis in patients with contraindications to early cholecystectomy.
Predictive factors of febrile neutropenia after pegfilgrastim as primary prophylaxis in patients treated with neoadjuvant chemotherapy of docetaxel, cisplatin, and 5-fluorouracil for esophageal cancer: Impact of febrile neutropenia on changes in neutrophil counts and relative dose intensity
Authors: Inagaki Takahito , Sato Miki , Kin Masaoki , Otsuka Koji , Murakami Masahiko , Kogo Mari 
Published: April 2022

Abstract
Purpose　We investigated factors predicting febrile neutropenia (FN) after the administration of pegfilgrastim as primary prophylaxis in patients with esophageal cancer who received neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF) to support the appropriate management of FN. We evaluated changes in neutrophil counts and relative dose intensity (RDI) after the incidence of FN.Methods　The retrospective study included 122 patients with esophageal cancer who were treated with DCF and pegfilgrastim at the Showa University Hospital, Japan, between April 2016 and August 2021. The primary outcome was the FN incidence after cycle 1 of DCF chemotherapy. The significant independent factors associated with FN incidence were selected using the multivariate analysis. Changes in neutrophil counts and RDI were compared between the FN and non-FN groups. Results　A total of 100 patients were included in the analysis. The incidence of FN was 21%. In the multivariate analysis, geriatric nutritional index (GNRI) < 92 (odds ratio [OR] 13.162, P < 0.001) and combination of platelet and neutrophil to lymphocyte ratio (COP-NLR) score of 0 (OR 4.619, P = 0.012) were independent predictors of FN. The neutrophil counts on day 7–10 and RDI in the FN group were significantly lower than those in the non-FN group (all P < 0.05). Conclusion　GNRI < 92 and COP-NLR score of 0 are important indicators to predict patients at high risk of DCF chemotherapy-induced FN. Furthermore, we showed that FN incidence after pegfilgrastim administration had a strong impact on delayed neutrophil recovery and reduced RDI.
Engineering ZIF-8 morphology for uptake of methomyl residues from wastewater by combining it with extracted lignin as an antibacterial
Authors: Abdelhameed Reda , Hasanin Mohamed , Abdel-Gawad Hassan , Hegazi Bahira 
Published: April 2022

Abstract
It is highly favorite to remove hazardous substances from insecticides by means of adsorbents with high adsorption uptake. Here, the hybridization between lignin and ZIF-8 and the removal of methomyl insecticides from wastewater were studied. The compounds were assured by FTIR, SEM, XRD, and BET analyses. The effect of some variables such as adsorbent dose and contact time on methomyl removal efficiency was investigated. The reaction mechanism was carefully scanned by SEM and FTIR. Kinetic and isometric parameters have been accurately matched with Langmuir models and pseudo-second-order models. The adsorption capacities in 60% ZIF-8@Lignin approached as high as 324.6 mg g− 1 which were much higher than Lignin alone. Compared to other works, the present work demonstrated better absorption capacity and cost-effectiveness. Antimicrobial testing approved that addition of ZIF-8 to lignin enhanced microbial activity and the MIC value. The lowest values against all tested microbial strains were 19 mg/mL.
A low-cost and highly optimized Analog circuit design to interface negative voltages to Single Ended ADC
Authors: Chalapala Sreekanthreddy 
Published: April 2022

Abstract
Interfacing negative(inverted) voltages to micro controller ADC is always challenging. On the fly solution available of using external ADC is expensive and pin compatible chips from different manufacturers is another test. High range of input signal interfacing needs reduced gain circuits, which is an additional task to generate on board negative power source for OpAmp Circuits. To avoid an external ADC chip and optimizing the cost, a dual OpAmp with some discrete and General-purpose comparators, analogue switches is added. This paper discusses about step-by-step design of circuitry to interface negative voltages to single ended ADC, and consideration on optimizing along with calculations.
Impact of Gender on Sleep Dissatisfaction in the Elderly
Authors: Salles Cristina , Santos Augusto Marianno Ferreira , Galtieri Ranuzia , Acuña-Castroviejo Dario , Cruz Miguel Meira e 
Published: April 2022

Abstract
Background: Sleep patterns vary depending on variables such as gender and age, but adequate and sufficient sleep is fundamental for well-being, health and survival regardless of these factors. The elderly experience changes in their sleep patterns, such as a decrease in total sleep time and an increase in the duration of more superficial sleep, contributing to the emergence of night awakenings, sleep fragmentation and sleep disorders. This study aims to evaluate the frequency of sleep disorders in patients aged 65 years and older according to gender. Methods: This is a cross-sectional study in which individuals aged 65 years or older who sought a sleep laboratory between October 2014 and October 2018 complaining of dissatisfaction with their habitual sleep were evaluated, and all patients who completed a set of clinical questionnaires containing information regarding sleep characteristics were included. Results: The sample comprised 115 patients with a mean age = 72.5±6.3 years, female gender = 53%, BMI = 27.7±6.9 kg/m², Epworth Scale = 8.5 (6-15), bedtime = 22:15±1:43 h, wake time = 5:51±1:31 h, total sleep time = 7:30±1:48 h. The most frequent sleep disorders were: snoring (89.6%), insomnia (47.8%), leg movement during sleep (46.1%), and witnessed apnea (44.3%). Women had more difficulty sleeping compared to men (62.3% vs. 31.5%; p<0.001), as well as body aches (67.2% vs. 40.7%; p=0.004), respectively. Men had a higher frequency of excessive daytime sleepiness than women (46.3% vs. 16.4%; p<0.001), as well as a higher frequency of the complaint "talking during sleep" (24.1% vs. 6.6%; p<0.016). Conclusion: The present study showed that elderly individuals have a high frequency of sleep-related dissatisfaction, namely related to breathing complaints associated with sleep and insomnia, suggesting, however, that symptoms and clinical presentation vary with gender. Considering the association of advanced age with other comorbidities and with polypharmacy, the clinical implications of these findings are relevant from both diagnostic and therapeutic perspectives.
Mechanism of fucoxanthin biosynthesis in Phaeodactylum tricornutum under different light intensities via FCP complex formation
Authors: Truong To Quyen , Park Yun Ji , Koo Song Yi , Choi Jae-Hyung , Enkhbayar Altai , Song Dae-Geun , Kim Sang Min 
Published: April 2022

Abstract
Fucoxanthin (FX), a primary carotenoid, is associated with the fucoxanthin-chlorophyll a/c binding protein (FCP) complex integrated into the thylakoid membrane (TM) which functions as a light-harvesting complex in Phaeodactylum tricornutum. Here, we aimed to elucidate the mechanism of FX biosynthesis under different light intensities via FCP complex formation. High light (HL) accelerated P. tricornutum growth more than low light (LL). The maximum values of FX content and productivity obtained under LL (1.7 mg/g and 2.12 mg/L/day, respectively) were substantially higher than those obtained under HL (0.54 mg/g and 0.79 mg/L/day, respectively). Notably, SDS-PAGE and photosynthetic pigment analyses revealed the enrichment of FCP antennae in the LL culture TM fractions but not the HL culture. Semi-quantification of FCP antenna protein using LC-MS/MS and RNA transcriptome analyses revealed that PtLhcf5 and PtLhcf8 played crucial roles in FCP biosynthesis under LL. P. tricornutum cultured under light transition exhibited FCP formation only in the early growth stage to meet the increased photosynthetic activity requirements under LL. Meanwhile, FCP degradation could be triggered by HL throughout the cultivation period. Therefore, FX production was highly correlated with FCP formation, and LL conditions in the early growth stage were critical for higher FX productivity.
Identification of alkaline salt tolerance genes in Brassica napus L. by transcriptome analysis
Authors: Xu Yu , Tao Shunxian , Zhang Qi , Wang Han , Li Ping , Zhang Yan , Bakirov Aldiyar , Cao Hanming , Qin Mengfan , Wang Kai , Shi Yiji , Liu Xiang , Zheng Lin , Xu Aixia , Huang Zhen 
Published: April 2022

Abstract
BackgroundSoil salt alkalization is one major abiotic factor reducing the productivity of crops worldwide, including rapeseed (Brassica napus L.), an indispensable oil crop and vegetable. The mechanism studies of alkali-salt-tolerance are helpful for the breeding of high resistant varieties and the expansion of the planting area. However, the study of the alkaline salt tolerance mechanism in rapeseed is limited. This study aimed to identify candidate genes related to the regulation of alkali salt tolerance in B. napus. ResultsIn the current study, B. napus line 2205 exhibited stronger tolerance to alkaline salt than B. napus line 1423. In line 2205, the lesser plasma membrane damage index, the accumulated osmotic adjustment substances, and higher antioxidant enzyme activities were contributed to alkaline tolerance. Ultrastructure observation found that the mesophyll cells of line 2205 had higher integrity compared with line 1423, further confirming that line 2205 suffered a lesser injury under alkali-salt stress. Transcriptome analysis showed that more genes responded to alkaline salt in line 2205, and the expressions of respective specific response genes were different in these two cultivars. The expression level of the line-1423-specific-response genes was lower in line 2205, which were primarily annotated to the cytosol, spliceosome, and ubiquitin-mediated proteolysis, whereas most of the specific response genes in line 2205 had a higher expression, which were mainly enriched in carbohydrate metabolism, photosynthetic processes, ROS regulating, and response to salt stress. It can be seen that the tolerance to alkaline salt is attributed to the high expression of some genes in these pathways. Based on these results, twelve cross-differentially expressed genes, including BnMDH2, BnGAPCs, BnACO1, BnGOXs, and BnGGTAs, were proposed as candidate genes for regulating alkali-salt tolerance in rapeseed.ConclusionsThe present study demonstrates that tolerant rapeseed exhibits superior physiological indicators and actively mobilizes genes involved in energy metabolism and ROS-related pathways to resist undesirable adverse signals from alkaline salts. The candidate genes provide reliable clues for further analysis of the resistance mechanism of rapeseed.