bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histopathological features have limited correlation with gene expression-based classifiers
Authors: de Weerd Simone van , Smit Marloes , Roelands Jessica , Mesker Wilma , Bedognetti Davide , Kuppen Peter , Putter Hein , Tollenaar Rob , Roodhart Jeanine , Hendrickx Wouter , Medema Jan Paul , Krieken Han van 
Published: July 2022

Abstract
The purpose of this study was to evaluate the association between four distinct histopathological features, (1) tumor infiltrating lymphocytes, (2) mucinous differentiation, (3) tumor-stroma ratio, (4) tumor budding and two gene expression-based classifiers, (1) consensus molecular subtypes (CMS), (2) colorectal cancer intrinsic subtypes (CRIS). All four histopathological features were retrospectively scored on hematoxylin and eosin-stained sections of the most invasive part of the primary tumor of 218 stage II and III colon cancer patients from two independent cohorts (AMC-AJCC-90 and AC-ICAM). RNA-based CMS and CRIS assignments were independently obtained for all patients. Contingency tables were constructed and χ2 test was used to test for statistical significance. Odds ratios with 95% confidence intervals were calculated. The presence of tumor infiltrating lymphocytes and a mucinous phenotype (>50% mucinous surface area) were positively correlated with CMS1 (p < 0.001 and p = 0.008) and CRIS-A (p = 0.006 and p < 0.001). The presence of mucus (≥ 10%) was strongly associated with CMS3: mucus was present in 64.1% of all CMS3 tumors. Although a strong association between tumor-stroma ratio and CMS4 was established in this study (p = 0.006), still 32 out of 61 (52.5%) CMS4 tumors were scored as stroma-low, indicating that CMS4 tumors cannot be identified solely based on stromal content. Higher budding counts were seen in CMS4 and CRIS-B tumors (p = 0.045 and p = 0.046). No other associations of the measured parameters were seen for any of the other CRIS-subtypes. Our analysis revealed that histopathologic features have limited correlation with CMS and CRIS subtypes. Identification of distinct molecular subtypes using histopathology alone proved to be infeasible. Our findings also indicate that histopathologic features and molecular subtypes should be seen as distinct biomarkers. Combining both molecular and morphologic features could potentially improve patient stratification.
Impact of high-grade patterns in early-stage lung adenocarcinoma: a multicentric analysis
Authors: Bertoglio Pietro , Aprile Vittorio , Ventura Luigi , Cattoni Maria Angela , Nachira Dania , Lococo Filippo , Perez Maria Rodriguez , Guerrera Francesco , Minervini Fabrizio , Querzoli Giulia , Bocchialini Giovanni , Bacchin Diana , Franzi Francesca , Rindi Guido , Bellafiore Salvatore , Femia Federico , Bogina Giuseppe Salvatore , Solli Piergiorgio , Kestenholz Peter , Ruffini Enrico , Paci Massimiliano , Margaritora Stefano , Imperatori Andrea Selenito , Lucchi Marco , Gnetti Letizia , Terzi Alberto Claudio 
Published: July 2022

Abstract
ObjectiveThe presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas.MethodsWe retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns.ResultsAmong 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p=0.020), but the latter had similar OS compared to T2a (p=0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p=0.034), and it was similar to T2a (p=0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p=0.024; HR 1.285 95% CI 1.033-1.599) and DFS (p=0.003; HR 1.196, 95% CI 1.054-1.344 respectively). These results were confirmed after the propensity score matching analysis.ConclusionspT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors.
Degree of dietary specialization on furanocoumarin-containing hostplants in a newly invasive species, Depressaria depressana (Lepidoptera: Depressariidae)
Authors: Dean Charles-Antoine Edouard , Katz Aron , Wu Wen-Yen , Berenbaum May R. 
Published: July 2022

Abstract
The genus Depressaria (Lepidoptera: Depressariidae) mostly comprises specialist herbivores with varying capacity for detoxification of defensive phytochemistry. Depressaria depressana , a Eurasian moth recently introduced into North America, is a family-level specialist of the Apiaceae, whose hosts include more than a dozen species in multiple tribes; Depressaria radiella is a family specialist of Eurasian origin that feeds almost exclusively on species in the genera Pastinaca and Heracleum throughout its native and introduced range. In eastern North America it is found almost exclusively on Pastinaca sativa , an invasive European species, and Heracleum maximum , a native species. We determined whether differences in furanocoumarin metabolism exist between D. depressana and two isolated populations of D. radiella, feeding exclusively on either P. sativa or H. maximum . We also compared gravimetric estimates of efficiency to assess D. depressana larval performance on different diets. Both populations of D. radiella metabolized furanocoumarins at a greater rate than D. depressana . Although there was no difference in rates of metabolism of linear furanocoumarins in the two populations of D. radiella , individuals collected from H. maximum metabolized angular furanocoumarins more rapidly. The gravimetric assessments of performance revealed that D. depressana exhibited highest efficiencies consuming D. carota ; moreover, this species could survive consuming fruits of Z. aurea , an apiaceous species native to North America. Our preliminary phylogenetic analysis, building on an earlier morphological analysis, incorporates the mitochondrial cytochrome oxidase subunit 1 data, and revealed that the presence or absence of furanocoumarins is not a strong predictor of species-level evolution in Depressaria .
Sensory descriptors for three edible Chilean seaweeds and their relations to umami components and instrumental texture
Authors: Figueroa Valentina , Bunger Andrea , Ortiz Jaime , Aguilera José Miguel 
Published: July 2022

Abstract
Although seaweeds exhibit many benefits as a food source, few studies have characterized their sensory attributes. An expert nine-member panel developed a vocabulary with 25 descriptors to describe the appearance, aroma, flavor, texture, and aftertaste of raw and cooked seaweeds consumed in Chile: Durvillaea antarctica, Pyropia spp., and Ulva lactuca. Subsequently, the vocabulary was used in a ranking descriptive analysis (RDA) to evaluate the sensorial properties and relate them with physicochemical and physical data. Sensory attributes of the three seaweeds were very different from each other but similar between treatments (raw and cooked). Pyropia spp., both cooked and hydrated, had the highest glutamate content (310 and 324 mg/100g d.w., respectively), and was perceived by the sensory panel as having the most umami taste. Cooked D. antarctica was perceived as sweeter, had more caramel notes than the hydrated seaweed and was sensed as cartilaginous and hard in accordance with its mechanical properties. Generalized Procrustes Analysis revealed that D. antarctica exhibited most of the desirable descriptors, such as caramel, umami and marine aromas while U. lactuca was described as bitter and moldy. This primary vocabulary can assist food scientists and chefs in the development of seaweed products and dishes for the consumer market.
Omentin ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy
Authors: Hu Jingui , Liu Tao , Fu Fei , Cui Zekun , Lai Qiong , Zhang Yuanyuan , Yu Boyang , Liu Fuming , Kou Junping , Li Fang 
Published: July 2022

Abstract
Background
Adipose tissue-derived adipokines are involved in various cross-talk between adipose tissue and other organs. Omentin, a novel adipokine, exerts vital roles in the maintenance of body metabolism, insulin resistance and the like. However, the protective effect of omentin in myocardial ischemia (MI)-induced heart failure (HF) and its specific mechanism remains unclear and to be elucidated.
Methods
The model of MI-induced HF mice and oxygen glucose deprivation (OGD)-injured cardiomyocytes were performed. Mice with overexpression of omentin were constructed by a fat-specific adeno-associated virus (AAV) vector system.
Results
We demonstrated that circulating omentin level diminished in HF patients compared with healthy subjects. Furthermore, the fat-specific overexpression of omentin ameliorated cardiac function, cardiac hypertrophy, infarct size and cardiac pathological features, and also enhanced SIRT3/FOXO3a signaling in HF mice. Additionally, administration with AAV-omentin increased mitochondrial fusion and decreased mitochondrial fission in HF mice, as evidenced by up-regulated expression of Mfn2 and OPA1, and downregulation of p-Drp1(Ser616). Then, it also promoted PINK1/Parkin-dependent mitophagy. Simultaneously, treatment with recombinant omentin strengthened OGD-injured cardiomyocytes viability, restrained LDH release, and enhanced the mitochondrial accumulation of SIRT3 and nucleus transduction of FOXO3a. Besides, omentin also ameliorated unbalanced mitochondrial fusion-fission dynamics and activated mitophagy, thereby, improving the damaged mitochondria morphology and controlling mitochondrial quality in OGD-injured cardiomyocytes. Interestingly, SIRT3 played an important role in the improvement effects of omentin on mitochondrial function, unbalanced mitochondrial fusion-fission dynamics, and mitophagy.
Conclusion
omentin improves MI-induced HF and myocardial injury by maintaining mitochondrial dynamical homeostasis and activating mitophagy via upregulation of SIRT3/FOXO3a signaling. This study provides evidence for further application of omentin in cardiovascular diseases from the perspective of cross-talk between heart and adipose tissue.
Data-driven Modelling of Engineering Systems with Small Data, a Comparative Study
Authors: Mohammadzaheri Morteza , Soltani Payam , Ziaeifar Hamidreza , Bahadur Issam , Zarog Musaab , Emadi Mohammadreza , Ghodsi Mojtaba 
Published: July 2022

Abstract
This paper equitably compares five different Artificial Intelligence (AI) models and a linear model to tackle two real-world engineering data-driven modelling problems with small number of experimental data samples, one with sparse and one with dense data. The models of both cases are shown to be highly nonlinear. In the case with available dense data, Multi-Layer Perceptron (MLP) evidently outperforms other AI models and challenges the claims in the literature about superiority of Fully Connected Cascade (FCC). However, the results of the problem with sparse data shows superiority of FCC, closely followed by MLP and neuro-fuzzy network.
Effect of hydrolysis and succinylation on the stability of dual-modified rennet casein and membrane separated casein emulsions under different environments
Authors: Li Hongjuan , Hou Dongyu , Wu Yifei , Yuan Yujing , Li Hongbo , Yu Jinghua 
Published: July 2022

Abstract
Casein is a common ingredient and can be used to improve the stability of dairy products. However, the poor solubility and emulsification properties of casein limit its further application. Therefore, modification of casein to improve its application properties is important. In this study, hydrolysis and succinylation were used to modify the casein separated with different methods (rennet casein (RC) and membrane separated casein (MC)). And Turbiscan stability index (TSI), salt ion (Na+) stability, freeze-thaw stability and storage stability of emulsions prepared by RC and MC were investigated. The results showed that succinylation modified protein structure and improved the stability of oil-in-water emulsions prepared by succinylated casein and succinylated casein hydrolysates. The TSI of succinylated rennet casein (RC-SA) and succinylation of membrane separated casein hydrolysates (MC-CHs-SA) stabilized emulsions showed a better stability. Protein succinylation could prevent adsorption and aggregation between droplets, improving the Na+ stability and storage stability of the emulsion. Succinylated casein had the best emulsification activity and emulsion stability. And the solubility of succinylated casein hydrolysates was significantly improved compared with succinylated casein. Emulsions prepared with succinylated RC hydrolysates had the smallest particle size and a more uniform particle size distribution compared with other samples. Succinylated MC hydrolyzates showed the best freeze-thaw stability. Therefore, hydrolysis could reduce the molecular weight of casein and significantly improved the solubility of succinylated casein, and succinylation could modify the protein structure and significantly improved the emulsion stability. Overall, hydrolysis and succinylation can be applied to modify casein to effectively improve the application properties in emulsion system.
Evaluation the preventive effect of probiotics on infection after colorectal cancer surgery: a systematic review and meta-analysis
Authors: Miri Ali , Jajarmi Vahid , Fard Amir Mohammad Milani , Parastouei Karim , Aghaie Seyed Mojtaba , Bahrami Shabnam , Ghaleh Hadi Esmaeili Gouvarchin 
Published: July 2022

Abstract
Background and objectives:
The current study's objective was to evaluate the probiotics' preventative effects on postoperative infections following colorectal cancer surgery. Our review's objective is to assess the probiotics' ability to prevent infection following colorectal cancer surgery in randomized controlled studies (RCT).
Methods
to examine the randomized controlled trials throughout the previous 10 years, a search of the electronic databases of PubMed, Scopus, Web of Science, EBSCO, and Embase was carried out from 2011 until 2021. Stata/MP v.16 software was used to conduct the meta-analysis (The Stata version that runs quickly).
Results
Eleven papers total, after review of 610 articles, were chosen to do this meta-analysis. Probiotics had an odds ratio of 1.13 (OR, 1.13 95 percent CI 0.83, 1.43, P0.05) for reducing the risk of postoperative compares the treatment groups to the normal control. Probiotics' average effects on first flatus time and postoperative pyrexia duration were (OR, -0.66 95 percent CI -0.84, -0.48. P0.05) and (OR, -0.36 95 percent CI -0.74, 0.02 P = 0.06), respectively, different from control group and intervention group.
Conclusion
Patients having surgery for colorectal cancer who are postoperatively infected benefit from taking probiotics.
Copper Nanoparticles Induce Apoptosis and Oxidative Stress in SW-480 Human Colon Cancer Cell Line
Authors: Ghasemi Parvin , Shafiee Gholamreza , Ziamajidi Nasrin , Abbasalipourkabir Roghayeh 
Published: July 2022

Abstract
Cu nanoparticles (CuNPs) have various applications in biomedicine, owing to their unique properties. As the effect of CuNPs on the induction of oxidative stress and apoptosis in the human colorectal cancer cell line SW480 has not yet been studied, we investigated the toxicity and mechanism of action of these NPs in SW480 cells. An MTT assay was performed to assess the effect of the particles on the viability of SW480 cells. The levels of oxidative stress were assessed after 24h of treatment with CuNPs by evaluating the ROS production. Antioxidant enzyme activity was assessed using a colorimetric method. To investigate the effect of NPs on cellular apoptosis, Hoechst33258 staining was performed, and the expression of Bax, Bcl2, and p53 genes was evaluated by qRT-PCR. MTT assay results showed that CuNPs inhibited the viability of SW480 cells. Moreover, the increase in ROS production at all three concentrations (31, 68, and 100 μg/ml) was statistically significant. It has been observed that CuNPs lead to increased expression of Bax and p53, and decreased expression of Bcl-2. Hoechst staining was performed to confirm apoptosis. In conclusion, the induction of apoptosis demonstrated the anticancer potential of CuNPs.
An Introspection Monitoring Library to Improve MPI Communication Time
Authors: Jeannot Emmanuel , Sartori Richard 
Published: July 2022

Abstract
In this paper we describe how to improve communication time of MPI parallel applications with the use of a library that enables to monitor MPI applications and allows for introspection (the program itself can query the state of the monitoring system). Based on previous work, this library is able to see how collective communications are decomposed into point-to-point messages. It also features monitoring sessions that allow suspending and restarting the monitoring, limiting it to specific portions of the code. Experiments show that the monitoring overhead is very small and that the proposed features allow for dynamic and efficient rank reordering enabling up to 2-time reduction of communication parts of some program.
Design and Analysis of IC Engine Combustion Chamber and Piston by Composite Materials (Al &amp; MG) Using Finite Element Analysis
Authors: Prajapati Shivam , MEHTA NISHI , THAKUR ABHISHEK NATH 
Published: July 2022

Abstract
Among all automotive and other industrial area components, engine pistons and combustion chambers are the most complicated. The development of an IC Engine with greater power capacity has been discovered to be appealing by the present trend. The goal of lightening the structure's weight and, by extension, reducing fuel consumption, is one of the design criteria. A better engine design has made this possible. The "Heart" of the engine is the piston and combustion chamber, and their operating conditions are the worst of all the major engine components. Therefore, it is crucial for the combustion chamber and piston's design and structural analysis. Thermal analysis and structural analysis are performed in this research. Operating gas pressure, temperature, and the material characteristics of the piston and combustion chamber are the parameters considered for the analysis. Boundary conditions employed in the analysis of pistons include pressure on the piston head under operating conditions, unequal temperature distribution from the piston head to the skirt, and heat flux and pressure for combustion chambers. In the current work, a single-cylinder, air-cooled combustion chamber and piston are created using Catia V5 software and saved in.igs format. The design is then loaded into the software Ansys (18.1 version), where analysis is then carried out. On various alloys of aluminium and magnesium, static structural analysis is first carried out, followed by thermal analysis, and the results are compared with those from FEA analysis. At the conclusion, the static structural analysis yielded three separate values: simulated outcomes, theoretical results, and percent error. The results have demonstrated that while an alloy containing a higher percentage of magnesium can tolerate high pressure and stress, the degree of deformation that results is also quite significant.
avian diversity importance in the climate of Nalanda Bihar
Authors: Mehta Jyoti , sharma gopal 
Published: July 2022

Abstract
This research paper was going to describe about the diversity of different types of avian in the wild life sanctuary in Nalanda Bihar. The number various kinds of species were recorded lively. Through this avian study the various types of avian were recorded which tells about the climate favourable condition according to their presence population. With help of this avian survey it was notice that the importance of conversation for this avian diversity in our ecosystem.
The Effect of Image Magnification on Measuring Radiographic Parameters for Scoliosis
Authors: Chang Yu-Tse , Yeh Yu-Cheng , Chen Wen-Jer , Lai Po-Liang 
Published: July 2022

Abstract
Study design
Reliability and agreement study
Background
Clinical evaluation of adolescent idiopathic scoliosis requires serial radiographic examinations. The purpose of this study was to determine whether image magnification can improve interobserver and intraobserver reliability and accuracy in the measurement of radiographic parameters of adolescent idiopathic scoliosis.
Methods
The radiographs of randomly selected scoliosis patients were reviewed. Three observers measured coronal Cobb angle, thoracic kyphosis, apical vertebral translation and sagittal vertical axis. The curves were measured as it first appeared on the screen (screen fit) without magnification (Technique 1x), 200% of screen fit (Technique 2x) and 400% of screen fit (Technique 4x). Interobserver and intraobserver reliability was assessed by intraclass correlation coefficient. We assessed the percentage of variation > 5° between the observers for each technique
Results
For coronal Cobb angle, the percentage of measurement variation > 5° was 12.5%, 1.6% for and 0% for Technique 1x, Technique 2x and Technique 4x respectively. Technique 2x was significantly better than Technique 1x in interobserver and intraobserver reliability. For thoracic hyphosis, the percentage of variation > 5° was 18.3%, 6.7% and 1.7% for Technique 1x, Technique 2x and Technique 4x respectively. Technique 4x significantly increased the interobserver and intraobserver reliability compared to Technique 1x. Measurements of distance parameters such as apical vertebral translation and sagittal vertebral axis demonstrate better reliability and were not influenced by image magnification.
Conclusions
Image magnification improves the reliability of coronal Cobb angle and thoracic kyphosis measurements. Reliability of apical vertebral translation and sagittal vertebral axis measurements are not influenced by image magnification. The authors recommend that at least 200% magnification of screen fit when measuring coronal Cobb angle and 400% magnification when measuring thoracic kyphosis.
Laparoscopic resection of right hemicolectomy, and rectal tumour for loose bowel stool: A Case Report
Authors: ALI MUHAMMAD , Ding Jianyue , Wang Yang , Diallo Maladho Tanta , Baral Shantanu , Wang Daorong 
Published: July 2022

Abstract
Rectal cancer with the ascending colon is rare. Herein, we report a patient who presented with diarrhea without obvious cause more than one month ago. A 67-year-old female came to our institution with frequent loose stool from one month. On CT examination, diagnosed with thickened intestinal wall at the junction of ascending colon, rectum, and sigmoid colon. Furthermore, colonoscopy exposed the rectum with stenosis and ileocecal mass. Radical resection by Dixon for rectal and hemicolectomy done for ascending colon. Postoperative pathology showed no clear vascular cancer plug invaded the entire intestinal wall and no cancer was found in the upper and lower wall. There has been no recurrence in the 25 months after the curative operation.