bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Stereochemical Analysis, and Transformation of Oxa-[7]orthocyclophene
Authors: Tomooka Katsuhiko , Iso Chisato , Hashimoto Yukiho , Suzuki Masaki , Kawasaki Yuuya , Igawa Kazunobu 
Published: July 2022

Abstract
Planar chiral oxa-[7]orthocyclophene 1a was designed and synthesized with two different synthetic routes. X-ray crystallographic analyses of 1a and its platinum complex revealed a highly distorted ring structure and the absolute stereochemistry of 1a, respectively. Epoxidation and [2,3]-Wittig rearrangement of 1a provided with central chiral molecules, without the loss of enantiomeric purity.
Fertility-sparing treatment of endometrial cancer - is it possible? A case study
Authors: Leziak Milena , Żak Klaudia , Satora Małgorzata , Szpyra Justyna , Kluz Natalia , Kułak Krzysztof 
Published: July 2022

Background: Endometrial cancer is the most common gynecological malignant neoplasm, which occurs in the majority of cases postmenopausally. The current standard of treatment is surgical - total hysterectomy. However, it may also occur in younger patients, who are planning pregnancy and want to choose fertility-sparing treatment. For those patients oral high dose progestin therapy with or without hysteroscopic resection should be proposed. It is usually a good option for women with well-differentiated (G1) cancers. For patients with higher grade (G2, G3) or contraindications to progestins, fertility-sparing treatment of endometrial cancer seems impossible.
Case report: We present the case of a 34-year old woman diagnosed gynecologically due to abnormal bleeding from the genital tract. Based on USG, she was diagnosed with endometrial polyp. As a treatment, hysteroscopic resection was performed. In the histopathological evaluation G2 endometrial cancer was diagnosed. The standard approach would be a total hysterectomy, but the patient was interested in fertility-sparing options. Due to contraindications to progestins a total hysteroscopic resection was performed counseling the patient about the risks of a novel approach. Histopathology revealed no residual disease and no other lesions during the first year of observations occurred.
Conclusion: Total hysteroscopic resection without further progestin therapy may offer the possibility to treat G2 endometrial cancer despite contraindications to the administration of progestins. Our case report should also encourage further evaluation of fertility-sparing management of endometrial cancer with higher than G1 grade.
Step towards elimination of Wuchereria bancrofti in Southwest Tanzania 10 years after mass drug administration with Albendazole and Ivermectin
Authors: Mnkai Jonathan , Marandu Thomas F. , Mhidze Jacklina , Urio Agatha , Maganga Lucas , Haule Antelmo , Kavishe Godfrey , Ntapara Elizabeth , Chiwerengo Nhamo , Clowes Petra , Horn Sacha , Mosoba Maureen , Lazarus Wilfred , Ngenya Abdallah , Kalinga Akili , Debrah Alex , Rieß Friedrich , Saathoff Elmar , Geldmacher Christof , Hoerauf Achim , Hoelscher Michael , Chachage Mkunde , Kroidl Inge 
Published: July 2022

Background
Lymphatic filariasis is a mosquito transmitted parasitic infection in tropical regions. Annual mass treatment with ivermectin and albendazole is used for transmission control of Wuchereria bancrofti, the infective agent of lymphatic filariasis in many African countries, including Tanzania.

Methodology
In a general population study in Southwest Tanzania, individuals were tested for circulating filarial antigen, an indicator of W. bancrofti adult worm burden in 2009 before mass drug administration commenced in that area. Seven annual rounds with ivermectin and albendazole were given between 2009 and 2015 with a population coverage of over 70%. Participants of the previous study took part in a follow-up activity in 2019 to measure the effect of this governmental activity.

Findings
One thousand two hundred and ninety nine inhabitants of Kyela district in Southwest Tanzania aged 14 to 65 years who had participated in the study activities in 2009 were revisited in 2010/11 and 2019. Among this group, the prevalence of lymphatic filariasis of the 14–65 years olds in 2009 was 35.1%. A follow-up evaluation in 2010/11 had shown a reduction to 27.7%. In 2019, after 7 years of annual treatment and an additional three years of surveillance, the prevalence had dropped to 1.7%, demonstrating successful treatment by the national control programme. Risk factors for W. bancrofti-infection were the occupation as farmer, male sex, and older age. Most infected individuals in the 2019 follow-up study already had a positive test for filarial antigen in 2009 and/or 2010/11.

Conclusions
This data supports the findings of the Tanzanian Neglected Tropical Disease Control Programme (NTDCP), who conducted Transmission Assessment Surveys and found an impressive reduction in the prevalence of LF in children. Our results complement this data by showing a similar decrease in prevalence of LF in the adult population in the same area. The elimination of LF seems achievable in the near future.
Comorbidity Influences the Comparative Safety of Biologic Therapy in Older Adults With Inflammatory Bowel Diseases
Authors: Cheng David , Kochar Bharati , Cai Tianxi , Ritchie Christine S. , Ananthakrishnan Ashwin N. 
Published: July 2022

INTRODUCTION:
There are limited data on comparative risk of infections with various biologic agents in older adults with inflammatory bowel diseases (IBDs). We aimed to assess the comparative safety of biologic agents in older IBD patients with varying comorbidity burden.

METHODS:
We used data from a large, national commercial insurance plan in the United States to identify patients 60 years and older with IBD who newly initiated tumor necrosis factor-α antagonists (anti-TNF), vedolizumab, or ustekinumab. Comorbidity was defined using the Charlson Comorbidity Index (CCI). Our primary outcome was infection-related hospitalizations. Cox proportional hazards models were fitted in propensity score-weighted cohorts to compare the risk of infections between the different therapeutic classes.

RESULTS:
The anti-TNF, vedolizumab, and ustekinumab cohorts included 2,369, 972, and 352 patients, respectively, with a mean age of 67 years. The overall rate of infection-related hospitalizations was similar to that of anti-TNF agents for patients initiating vedolizumab (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.84–1.04) and ustekinumab (0.92, 95% CI 0.74–1.16). Among patients with a CCI of >1, both ustekinumab (HR: 0.66, 95% CI: 0.46–0.91, p-interaction <0.01) and vedolizumab (HR: 0.78, 95% CI: 0.65–0.94, p-interaction: 0.02) were associated with a significantly lower rate of infection-related hospitalizations compared with anti-TNFs. No difference was found among patients with a CCI of ≤1.

DISCUSSION:
Among adults 60 years and older with IBD initiating biologic therapy, both vedolizumab and ustekinumab were associated with lower rates of infection-related hospitalizations than anti-TNF therapy for those with high comorbidity burden.
Una idea-guía liberadora
Authors: San Miguel de Pablos José Luis 
Published: July 2022

La crisis multidimensional por la que atraviesa actualmente la humanidad coloca en primer plano la cuestión, más que de «la salida de la crisis», de la superación de los condicionamientos negativos que han conducido a ella. Más allá de las causas próximas reconocibles (el egoísmo individualista, la codicia de los banqueros y brokers, el capitalismo neoliberal...) se hallan las apuestas paradigmáticas, la Weltanschauung dominante que inspira las conductas erróneas. En el artículo se sostiene que a la metafísica materialista —que el autor distingue del ateísmo—, en tanto que idea-guía principal de la modernidad, corresponde gran parte de la responsabilidad por las patologías de la sociedad actual, a cuyo clímax estamos asistiendo.
Se asume que el mundo ha experimentado tales transformaciones que ninguna de las concepciones metafísicas o criptometafísicas a las que estamos acostumbrados sirve para fundamentar una guía de actuación capaz de sacarnos del atolladero. Y se propone una idea de fondo que se estima que sí podría hacerlo: un noocentrismo, la consideración de la consciencia como la realidad fundamental y, por supuesto, referencial. Un neoespiritualismo, si se quiere, capaz de fundamentar una Ética universal, y orientado a la liberación individual y colectiva del ser humano, en armonía con una Naturaleza entendida como de igual importancia, y dejando atrás el espejismo pseudocientífico —y en realidad sojuzgador y bloqueante— del materialismo metafísico.
ANALISIS GANGGUAN DAN SISTEM PROTEKSI KELISTRIKAN PADA STUDI PENYAMBUNGAN PEMBANGKIT LISTRIK TENAGA MIKROHIDRO DENGAN KE JALA-JALA SISTEM DISTRIBUSI 20 KV JAWA TENGAH
Authors: Sisintito Hikma , Facta Mochammad , Sinuraya Enda Wista 
Published: July 2022

Aliran daya, analisis gangguan dan setting/resetting proteksi yang dilakukan pada makalah ini dilakukan pada saluran distribusi 20 kV Batang 10 sebelum adanya PLTM dan setelah adanya PLTM. Aliran daya, analisis gangguan dan setting/resetting proteksi serta menganalisis koordinasi proteksi dilakukan dengan simulasi pada software ETAP 16.0, Setelah melakukan analisis aliran daya didapatkan hasil dengan voltage drop paling besar adalah 3,09% yaitu , ferekuensi masih dalam rentang 48,5 -51 Hz, power factor ­rata-rata adalah 93,5%. Sistem proteksi tenaga listrik sangat berguna dalam hal melindungi komponen komponen tenaga listrik, demi menghasilkan koordinasi yang bagus harus dilakukan setting/reseting yang bagus. Setting dan resetting yang dilakukan sudah berdasarkan IEC 60255, Hasil Analisis dari sistem proteksi PLTM Kambangan sampai ke jala jala adalah sudah bagus dikarenakan waktu pemutusan CB yang berkaitan dengan PLTM sudah dibawah batas maksimum waktu pemutusan, Dapat dilihat pada waktu pemutusan kritis CB 30 yang didekat PLTM adalah 0,233 s sedangkan waktu putus CB 30 setelah dilakukan setting relay adalah 0,03 s, hal itu membuat generator yang ada pada PLTM akan aman dari peristiwa lepas sinkron.
ANALISIS KINERJA GENERATOR PADA STUDI PENYAMBUNGAN PEMBANGKIT LITRIK TENAGA MINIHIDRO (PLTM) DENGAN JALA-JALA
Authors: Suslamet Suslamet , Facta Mochammad , Sinuraya Enda Wista 
Published: July 2022

Critical clearing time (CCT) sangat penting terhadap kestabilan sistem kelitrikan akibat adanya gangguan. Sistem kelistrikan akan stabil apabila gangguan dihilangkan dibawah nilai waktu pemutussan kritisnya dan sebaliknya sistem tidak stabil. Nilai CCT diperoleh dengan metode kriteria luas sama dan time domain simulation (TDS) pada software ETAP. Nilai CCT dengan metode kriteria luas tidak mempertimbangkan adanya respon governor dan AVR. Sedangkan dengan metode trial error menggunakan TDS lebih akurat karena mempertimbangkan respon governor dan AVR dengan cara mengamati respon sudut rotor dalam range stabil dan tidak stabil pada waktu tertentu. Selain menentukan nilai CCT dalam studi penyabungan perlu dilakukan analisis kondisi sistem kelistrikan PLN apabila PLTM Kambangan tersambung dengan jala-jala. Analisis kinerja generator dengan mempertimbangkan AVR dan Governor. Kestabilan transien dengan mengamati respon sudut rotor, frekuensi dan tegangan pada pembangkit PLTM Kambangan. Dengan adanya PLTM Kambangan dapat memperbaiki sistem kelitrikan yang ada. Nilai CCT dengan metode kriteria luas sama pada tiga titik gangguan diperoleh 0,233 detik di Keluaran Penyulang Batang-10, titik D 0,231 detik terletak 2,04 km dan titik E 0,230 detik yang terletak 0,8 km dari Power House. Dengan TDS yakni rentang 0,400-0,401 detik di Batang-10, 0,282-283 detik di titik D dan 0,268-269 detik di titik E.
MRI characterization of skeletal muscle size and fatty infiltration in long‐term trained and untrained individuals
Authors: Emanuelsson Eric B. , Berry David B. , Reitzner Stefan M. , Arif Muhammad , Mardinoglu Adil , Gustafsson Thomas , Ward Samuel R. , Sundberg Carl Johan , Chapman Mark A. 
Published: July 2022

AbstractThis study investigated body composition measures in highly trained and untrained individuals using whole‐body magnetic resonance imaging (MRI). Additionally, correlations between these measures and skeletal muscle gene expression were performed. Thirty‐six individuals were included: endurance‐trained males (ME, n = 8) and females (FE, n = 7), strength‐trained males (MS, n = 7), and untrained control males (MC, n = 8) and females (FC, n = 6). MRI scans were performed, and resting M. vastus lateralis (VL) biopsies were subjected to RNA sequencing. Liver fat fraction, visceral adipose tissue volume (VAT), total body fat, and total lean tissue were measured from MRI data. Additionally, cross‐sectional area (CSA) and fat signal fraction (FSF) were calculated from Mm. pectoralis, M. erector spinae and M. multifidus combined, Mm. quadriceps, and Mm. triceps surae (TS). Liver fat fraction, VAT, and total body fat relative to body weight were lower in ME and FE compared with corresponding controls. MS had a larger CSA across all four muscle groups and lower FSF in all muscles apart from TS compared with MC. ME had a lower FSF across all muscle groups and a larger CSA in all muscles except TS than MC. FE athletes showed a higher CSA in Mm. pectoralis and Mm. quadriceps and a lower CSA in TS than FC with no CSA differences found in the back muscles investigated. Surprisingly, the only difference in FSF between FE and FC was found in Mm. pectoralis. Lastly, correlations between VL gene expression and VL CSA as well as FSF showed that genes positively correlated with CSA revealed an enrichment of the oxidative phosphorylation and thermogenesis pathways, while the genes positively correlated with FSF showed significant enrichment of the spliceosome pathway. Although limited differences were found with training in females, our study suggests that both regular endurance and resistance training are useful in maintaining muscle mass, reducing adipose tissue deposits, and reducing muscle fat content in males.
The mundanity of translanguaging and Aboriginal identity in Australia
Authors: Tankosić Ana , Dovchin Sender , Oliver Rhonda , Exell Mike 
Published: July 2022

Abstract
Drawing on ethnographic interview analysis of Aboriginal participants in Australia, this study seeks to expand the critical discussions in Applied Linguistics by understanding the concept of translanguaging in relation to its “mundanity” (or ordinariness). Our data shows that rather than perceiving translanguaging as extraordinary, for Aboriginal speakers it is more likely to be considered normal, unremarkable, mundane, and as a long-existing phenomenon. The concept of the mundanity of translanguaging is thereby expanded through three main discussions in this article: 1) negotiating identity and resisting racism, where the Aboriginal speakers choose to translanguage using their full linguistic repertoires, but with appropriate communicative adjustments made for their interlocutor; 2) a display of respect towards their land, heritage and language; and 3) as an inherent and mundane everyday practice where they constantly negotiate between heritage languages, English, Kriol, and Aboriginal English varieties. The significance of this study lies in the normalisation of translanguaging as a mundane disinvention strategy, as this urges us to perceive linguistic separateness as a colonial ideological construct that is used to exhibit control over diverse peoples and to maintain uniformity and stability of nation-states.
Gain enhancement of a SIW H-plane horn antenna using of metamaterial array
Authors: Karami-Raviz Afsaneh , Mohajeri Farzad 
Published: July 2022

Abstract
In this paper, a novel, compact and high gain H-plane horn antenna with Substrate Integrated Waveguide (SIW) technology is examined for X-band applications. To increase the gain, an array of metamaterials is used by cutting the gap in the aperture area of the antenna in high metallization. After examining the size and position of the metamaterial unit cell and several array elements, which act as a focusing structure, and in addition, by reducing the electric permittivity coefficient of the substrate and consequently reducing the losses, an increase in gain is achieved. The performance of the proposed SIW horn antenna with metamaterials has been compared with the SIW conventional horn antenna without metamaterials. To highlight this point, the proposed antenna was designed with CST software. Then, it was fabricated and measured. Measurements show that the gain of the modified antenna is 9.2 dBi, which is 6.2 dBi higher than a conventional antenna.
Multiple Drive Shaft Fractures in Lift Oil Pumps
Authors: Neidel A. , Giller M. , Gädicke T. 
Published: July 2022

Abstract
Several high-pressure lift oil pump failures were reported from the field. These assemblies are used to inject lubrication oil into the sliding bearings of heavy rotating turbomachinery equipment, such as steam and gas turbine rotors, often weighing in excess of a hundred tons. This ensures that the rotor shaft “floats” on a lube oil film even at low rotational speeds, when hydro-dynamic lubrication conditions have not yet been fully established. A fractured spline shaft, which was the driven shaft of one of the failed pumps, was received from the client for the determination of the metallurgical root cause of failure. The subject spline shaft failed due to torsional overload. This cracked the hardened case and initiated high cycle fatigue (HCF) cracking as secondary damage. The main fatigue cracks were nucleated at overload fractures in the hardened case, in the fillet radii at the base of the teeth of the spline shaft. No evidence of any material defects that could have contributed to the failure or could even have been causative for it was found.
Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies
Authors: Osmaniye Derya , Sağlık Begüm Nurpelin , Levent Serkan , Özkay Yusuf , Kaplancıklı Zafer Asım , Turan Gülhan 
Published: July 2022

Abstract
In this study, novel pyridine-containing thiazolyl hydrazone derivatives were synthesized. Structure determinations of the compounds were performed using 1H NMR, 13C NMR and HRMS techniques. The biological activities of the compounds were evaluated against MAO enzymes by in vitro fluorometric method. As a result of activity studies, compound 3a showed selective inhibitory activity against MAO-B enzyme with IC50 = 0.088 + 0.003 µM. The selectivity index of this compound is greater than 1136. Molecular docking studies were carried out using 2V5Z crystal. It has been observed that docking studies and activity studies are in harmony.
Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition
Authors: Arora Rajika , Bodak Maxime , Penouty Laura , Hackman Cindy , Ciaudo Constance 
Published: July 2022

AbstractLINE‐1 (L1) retroelements have retained their ability to mobilize. Mechanisms regulating L1 mobility include DNA methylation in somatic cells and the piRNA pathway in the germline. During preimplantation stages of mouse embryonic development, however, both pathways are inactivated leading to a window necessitating alternate means of L1 regulation. We previously reported an increase in L1 levels in Dicer_KO mouse embryonic stem cells (mESCs), which was accompanied by only a marginal increase in retrotransposition, suggesting additional mechanisms suppressing L1 mobility. Here, we demonstrate that L1 ribonucleoprotein complexes (L1 RNP) accumulate as aggregates in the cytoplasm of Dicer_KO mESCs along with the RNA helicase MOV10. The combined overexpression of L1 ORF1p and MOV10 is sufficient to create L1 RNP aggregates. In Dicer_KO mESCs, MOV10 is upregulated due to the loss of its direct regulation by miRNAs. The newly discovered posttranscriptional regulation of Mov10, and its role in preventing L1 retrotransposition by driving cytosolic aggregation, provides routes to explore for therapy in disease conditions where L1s are upregulated.
Analysis of the ELT Pre-Services Teacher Lesson Plan: A Case on the Vocabulary Discussion
Authors: Elismawati Elismawati , Saun Saunir , Arwemi Arwemi , Hadeli Hadeli , Alazmi Hidayat 
Published: July 2022

As the lesson plan is considered of main requirements for both teacher and practiced teacher and vocabulary discussion is essential to include. This research is aimed to identify the vocabulary discussion used by teacher in the Lesson Plan. Using 22 peaces ELT ELT lesson plan, the research was done by implementing documentation study. Regarding the distinction indicators of both KTSP and K13 curriculum, it was found that the lesson have some limitation in using the vocabulary discussion in which there are only 9.09% of the lesson plan that included the vocabulary discussion as a step in the teaching of reading for comprehension before doing reading activity, and 4.55% offers it after the students read the text. Most of the documents do not include the steps of vocabulary discussion in the teaching of reading for comprehension. Finally, 19 or 86.36% that did not offer the vocabulary discussion.
Asociación autocuidado y riesgo pie diabético
Authors: Ramírez-Perdomo Claudia Andrea , Perdomo-Romero Alix Yaneth , Rodriguez-Vélez Maria Elena 
Published: July 2022

Objetivo. Determinar la asociación entre la autovaloración y autocuidado del pie en pacientes con Diabetes Mellitus 2.
Métodos. Estudio descriptivo, transversal, muestreo aleatorio estratificado, 302 participantes diagnosticados con Diabetes Mellitus tipo 2. Se aplicaron los instrumentos “prácticas de Autocuidado del Pie en Pacientes con Diabetes Mellitus 2” y “Pie–Risk-Paciente”. Se utilizó el árbol de decisión y el concepto de entropía.
Resultados: de los participantes el 17,88% presentó riesgo moderado y el 81,12% riesgo leve, asociación de las variables años de diagnóstico, estado civil y puntaje final del autocuidado con el grado de riesgo de pie diabético. Con el árbol de decisión se obtuvo precisión media del modelo de 80%, desviación estándar de 0.08, el modelo tiene una alta-moderada capacidad de predicción con las variables consideradas
Conclusiones. El uso de la herramienta Pie Risk Paciente, es importante para el conocimiento, manejo y autocuidado del pie de las personas enfermas.
El ritual de la Ayahuasca: patrimonio cultural nacional de Perú
Authors: A. Giove Rosa 
Published: July 2022

El 24 de junio de 2008, el Gobierno peruano declaró el «conocimiento y usos tradicionales de la Ayahuasca practicados por las comunidades nativas amazónicas» como Patrimonio Cultural de la Nación. La inspiración que llevó a este importante logro fue proteger el uso ritual del brebaje Ayahuasca como tradicionalmente practicado durante siglos por las comunidades indígenas amazónicas, incluyendo su componente ritual intangible, el conocimiento de los curanderos y los propios curanderos, favoreciendo al mismo tiempo la protección del medio ambiente y la sostenibilidad de los recursos vegetales implicados. En las últimas dos décadas se han investigado en profundidad los mecanismos de acción de la Ayahuasca y su potencial terapéutico en varios campos. Sin embargo, trece años después de la promulgación de esta declaración, quedan aún pendientes regulaciones que puedan ofrecer una protección concreta, mientras observamos crecientes presiones comerciales y riesgos asociados al uso irresponsable de la Ayahuasca y de otras plantas psicoactivas en el contexto del turismo chamánico.