bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
Authors: Woronyczová Jana , Nováková Miroslava , Leníček Martin , Bátovský Miloš , Bolek Emil , Cífková Renata , Vítek Libor 
Published: June 2022

Abstract
Objectives
Bilirubin is a potent endogenous antioxidant and immunomodulating substance, which is also implicated in both cell signalling and various metabolic pathways. Mild elevation of systemic bilirubin concentrations provides substantial protection against many diseases of civilization. Rare published reports have suggested that serum bilirubin might also be relevant to sports performance. The purpose of the current study was to evaluate serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in elite athletes.

Methods
The study was carried out in 536 consecutive healthy elite athletes and in 2594 individuals of the Czech post-MONICA study representing the general Czech population. Serum bilirubin concentrations, the prevalence of benign hyperbilirubinemia > 17 µmol/L (1 mg/dL, a phenotypic sign of GS), and a variant of the UGT1A1 gene promoter responsible for GS manifestation in Caucasians (rs81753472) were evaluated in study subjects.

Results
Compared to the general Czech population, significantly higher serum bilirubin concentrations were found in elite athletes (9.6 vs. 11.6 µmol/L, p < 0.001), both in men (11.3 vs. 12.6 µmol/L, p < 0.001) and women (8.3 vs. 10.5 µmol/L, p < 0.001). Furthermore, the prevalence of GS was also significantly higher in elite athletes (9.6 vs. 22%, p < 0.001) together with the tendency to higher frequencies of the genotypes (TA)7/7 and (TA)6/7UGT1A1.

Conclusion
Elite athletes have significantly higher concentrations of serum bilirubin, the most potent endogenous antioxidant substance known. Simultaneously, the prevalence of GS syndrome is also much higher in elite athletes, suggesting that a mild elevation of serum bilirubin might predispose to better sports performance.
Rational durability of optical properties of chameleon effect of Omnichroma and Essentia composite thermocycled in black dark drinks (in vitro study)
Authors: Abdelhamed Bassma , Metwally Asmaa Abdel-Hakeem , Shalaby Heba A. 
Published: June 2022

AbstractBackgroundThis study evaluated the durability of optical properties of chameleon effect of Omnichroma and Essentia composite thermocycled in black dark drinks. 180 specimens of 10 mm diameter × 2 mm thickness from each tested composite material were prepared; Omnichroma and Essentia. 60 specimens were thermo-cycled for 2500 and 5000 cycles in Coffee and Coca-Cola in addition to Distilled water as a reference group for color change evaluation. Color change (ΔE) was calculated and water sorption and solubility were measured after thermocycling for 2500 and 5000 cycles in different dark drinks and water. The surface chemical changes were assessed by FTIR. All data were statistically analyzed.ResultsIn all tested groups, Omnichroma recorded the highest significant color change (35.80 ± 4.13) and sorption values (8.30 ± 0.48) on the contrary the least solubility value (− 8.29 ± 0.81) in all tested drinks after thermocycling to 5000.ConclusionsColor durability of Omnichroma negatively affected in dark drinks. Water sorption of Omnichroma negatively affected after aging 3 and 6 months. Water solubility might not adversely affect the color change. Thermocycling in different dark drinks adversely affected the color stability of both selected Chameleon composite types.
MicroRNAs influence and longevity
Authors: Eshkoor Sima Ataollahi , Ghodsian Nooshin , Akhtari-Zavare Mehrnoosh 
Published: June 2022

Abstract
Background
MiRNAs play critical roles in the regulation of cellular function, life span, and the aging process. They can affect longevity positively and negatively through different aging pathways.

Main text
MiRNAs are a group of short non-coding RNAs that regulate gene expressions at post-transcriptional levels. The different types of alterations in miRNAs biogenesis, mRNA expressions, and activities of miRNA-protein complexes can affect the regulation of normal post-transcriptional gene process, which may lead to aging, age-related diseases, and an earlier death. It seems that the influence of deregulation of miRNAs on senescence and age-related diseases occurring by targeting aging molecular pathways can be used for diagnosis and prognosis of them. Therefore, the expression and function of miRNAs should be studied more accurately with new applicable and validated experimental tools. However, the current review wishes to highlight simply a connection among miRNAs, senescence and some age-related diseases.

Conclusion
Despite several research indicating the key roles of miRNAs in aging and longevity, further investigations are still needed to elucidate the essential roles of miRNAs in controlling mRNA regulation, cell proliferation, death and/or protection during stress and health problems. Besides, more research on miRNAs will help to identify new targets for alternative strategies regarding effectively screen, treat, and prevent diseases as well as make slow the aging process.
Brain predictors of fatigue in rheumatoid arthritis: A machine learning study
Authors: Goñi María , Basu Neil , Murray Alison D. , Waiter Gordon D. 
Published: June 2022

Background
Fatigue is a common and burdensome symptom in Rheumatoid Arthritis (RA), yet is poorly understood. Currently, clinicians rely solely on fatigue questionnaires, which are inherently subjective measures. For the effective development of future therapies and stratification, it is of vital importance to identify biomarkers of fatigue. In this study, we identify brain differences between RA patients who improved and did not improve their levels of fatigue based on Chalder Fatigue Scale variation (ΔCFS≥ 2), and we compared the performance of different classifiers to distinguish between these samples at baseline.

Methods
Fifty-four fatigued RA patients underwent a magnetic resonance (MR) scan at baseline and 6 months later. At 6 months we identified those whose fatigue levels improved and those for whom it did not. More than 900 brain features across three data sets were assessed as potential predictors of fatigue improvement. These data sets included clinical, structural MRI (sMRI) and diffusion tensor imaging (DTI) data. A genetic algorithm was used for feature selection. Three classifiers were employed in the discrimination of improvers and non-improvers of fatigue: a Least Square Linear Discriminant (LSLD), a linear Support Vector Machine (SVM) and a SVM with Radial Basis Function kernel.

Results
The highest accuracy (67.9%) was achieved with the sMRI set, followed by the DTI set (63.8%), whereas classification performance using clinical features was at the chance level. The mean curvature of the left superior temporal sulcus was most strongly selected during the feature selection step, followed by the surface are of the right frontal pole and the surface area of the left banks of the superior temporal sulcus.

Conclusions
The results presented evidence a superiority of brain metrics over clinical metrics in predicting fatigue changes. Further exploration of these methods may support clinicians to triage patients towards the most appropriate fatigue alleviating therapies.
Pembelajaran Bermakna Analisis Real Secara Daring pada Masa Pandemi Covid-19
Authors: Latif Burhanuddin 
Published: June 2022

Penelitian ini memiliki tujuan untuk mengetahui sejauh mana pembelajaran bermakna telah dilakukan oleh mahasiswsa selama perkuliahan Analisis Real secara daring pada masa pandemi Corona Virus Disease (Covid-19). Metode yang digunakan adalah metode survey yang terdiri dari 15 pernyataan dengan setiap indikator diwakili oleh 3 buah pernyataan. Survey dilakukan kepada 34 orang mahasiswa yang mengambil mata kuliah Analisis Real. Hasil survey dianalisis menggunakan analisis proporsi dengan melihat persentase dari setiap pernyataan untuk setiap indikator. Berdasarkan data, diperoleh hasil bahwa mayoritas (>60%) telah belajar secara active, constructive, intentional, dan cooperative. Sementara sebagaian (>50%) merasa masih belum dapat belajar secara authentic. Dalam kondisi pandemi Covid-19 ini yang memaksa semua proses pembelajaran dilakukan secara daring menuntut dosen untuk cermat memilih media daring yang cocok diterapkan dengan memperhatikan kondisi mahasiswa dan dosen. Dengan hasil peneltian ini diharapkan dosen dapat mengetahui kelemahan-kelemahan apa yang dialami mahasiswa saat pembelejaran bermakna selama perkuliahan Analisis Real secara daring dilaksanakan dan dapat dijadikan dasar bagi pemilihan media daring lainnya bahkan mengkombinasikannya.
Analisis Kemampuan Berpikir Kreatif Matematis melalui Problem Posing Bersifat Open Ended
Authors: Prianto Agus 
Published: June 2022

Penelitian ini bertujuan mendiskripsikan, mengekplorasi dan menganalisis kemampuan berpikir kreatif matematis siswa melalui problem posing bersifat open ended. Subjek penelitian ini sebanyak 32 siswa SMP Negeri 1 Jepara. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian diskriptif. Pengumpulan data dilakukan dengan langkah memberikan informasi, kemudian meminta siswa membuat soal (pertanyaan) sebanyak mungkin dan selesainnya. Jawaban siswa dianalisis secara diskriptif berdasarkan aspek kemampuan kreatif matematis yang meliputi fluency, flexibility, dan novelty. Hasil penelitian ini menunjukkan bahwa kemampuan berpikir kreatif matematis siswa pada aspek fluency mencapai 78,13%; aspek flexibility mencapai 31,25%; dan aspek novelty hanya mencapai 6,25%. Kemampuan berpikir kreatif matematis siswa umumnya pada dua aspek yaitu fluency dan flexibility.
Bahan Ajar Matakuliah Pemodelan Matematika untuk Memfasilitasi Kemampuan Berpikir Kritis Mahasiswa
Authors: Khasanah Uswatun , Arif Nurnugroho Burhanudin 
Published: June 2022

Kemampuan berpikir kritis mahasiswa perlu diajarkan sebagai bekal dalam menghadapi tantangan dunia kerja. Kemampuan ini perlu dilatihkan melalui kegiatan perkuliahan di perguruan tinggi. Matakuliah Pemodelan Matematika merupakan salah satu matakuliah pada program studi Pendidikan Matematika Universitas Ahmad Dahlan yang dapat digunakan untuk mengembangkan kemampuan berpikir kritis mahasiswa. Karakteristik dari matakuliah pemodelan matematika yang memerlukan kemampuan berpikir tingkat tinggi menjadi salah satu alasannya. Penelitian ini bertujuan untuk mengembangkan bahan ajar matakuliah pemodelan matematika yang dapat meningkatkan k emampuan berpikir kritis mahasiswa. Dalam menggembangkan bahan ajar matakuliah pemodelan matematika, prosedur penelitian yang digunakan adalah 4-D model. Model pengembangan 4-D meliputi empat tahap yaitu, define, design, develop, dan disseminate. Instrumen yang digunakan dalam penelitian ini berupa lembar penilaian bahan ajar oleh ahli dan juga soal tes kemampuan berpikir kritis. Hasil penelitian menunjukkan bahwa bahan ajar matakuliah pemodelan matematika dikatakan dapat memfasilitasi peningkatan kemampuan berpikir kritis mahasiswa. Berdasarkan penilaian ahli terhadap bahan ajar matakuliah pemodelan matematika diperoleh skor rata-rata 80,02 (kategori sangat baik). Selain itu hasil tes kemampuan berpikit kritis mahasiswa menunjukkan adanya peningkatan terhadap kemampuan berpikir kritis mahasiswa secara kualitatif.
Comparative analysis of the effectiveness of the combined method of inserting pedicle screws with the free-hand technique in patients with idiopathic scoliosis
Authors: Kolesov S. V. , Kolyan V. S. , Kazmin A. I. , Gulaev E. V. 
Published: June 2022

Objective. To analyze intraoperative data and results of treatment of patients with idiopathic scoliosis with two options of the open insertion of pedicle screws using the free-hand technique.Material and Methods. The data of 457 patients aged 16–35 years who underwent surgical treatment for idiopathic scoliosis by one surgeon were analyzed. In 236 patients (Group I), the screws were placed manually, and in 221 (Group II) – using power tool. The preparation of the canal for pedicle screws in both groups was performed using the free-hand technique. The correct position of the screws wasassessed intraoperatively using an image intensifier and neurophysiological monitoring. The duration of surgery and X-ray monitoring, blood loss, and the presence of intra- and postoperative complications were assessed.Results. In Group I, 4243 screws were inserted, and in Group II – 3978. The correct position of pedicle screws was recorded in 89.1 % of cases in Group I, and in 89.6 % of cases in Goup II. In Group I, the incorrect position of anchor elements was detected in 10.9 % of cases, and in Group II – in 10.4 % of cases. The number of screws re-positioned intraoperatively corresponded to the number of incorrectly positioned screws. There was a statistically significant difference in the volume of intraoperative blood loss and duration of surgery betweenpatients of both groups (p < 0.05).Conclusion. The development and active introduction of high-tech methods of surgical treatment of spinal deformities increase the number of interventions performed annually. The proposed combined method of surgical treatment seems to be optimal because manual formation of the canal reduces the risk of intraoperative complications, and the use of power tool during screw placement shortens duration of surgery and reduces blood loss.
Magnetofluid unsteady electroosmotic flow of Jeffrey fluid at high zeta potential in parallel microchannels
Authors: Ren Meirong , Zhang Tiange , Cui Jifeng , Chen Xiaogang , Wu Bixia 
Published: June 2022

Abstract
In this article, the magnetofluid unsteady electroosmotic flow (EOF) of Jeffrey fluid with high zeta potential is studied by using the Chebyshev spectral method and the finite difference method. By comparing the potential distribution and velocity distribution obtained by the Chebyshev spectral method and finite difference method, it is concluded that the Chebyshev spectral method has higher precision and less computation. Then the numerical solution obtained by the Chebyshev spectral method is used to analyze the flow characteristics of Jeffrey fluid at high zeta potential. The results show that the velocity of Jeffrey fluid increases with the increase of the wall zeta potential and electric field intensity. The oscillation amplitude of velocity distribution increases with the increase of relaxation time, but decreases with the increase of retardation time. With the increase of Hartmann number, the velocity first increases and then decreases. The positive pressure gradient promotes the flow of fluid, and the reverse pressure gradient impedes the flow of fluid.
The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK
Authors: Ke Francine S , Holloway Steven , Uren Rachel T , Wong Agnes W , Little Melissa H , Kluck Ruth M , Voss Anne K , Strasser Andreas 
Published: June 2022

AbstractThe intrinsic apoptosis pathway, regulated by the BCL‐2 protein family, is essential for embryonic development. Using mice lacking all known apoptosis effectors, BAX, BAK and BOK, we have previously defined the processes during development that require apoptosis. Rare Bok−/−Bax−/−Bak−/− triple knockout (TKO) mice developed to adulthood and several tissues that were thought to require apoptosis during development appeared normal. This raises the question if all apoptosis had been abolished in the TKO mice or if other BCL‐2 family members could act as effectors of apoptosis. Here, we investigated the role of BID, generally considered to link the extrinsic and intrinsic apoptosis pathways, acting as a BH3‐only protein initiating apoptosis upstream of BAX and BAK. We found that Bok−/−Bax−/− Bak−/−Bid−/− quadruple knockout (QKO) mice have additional developmental anomalies compared to TKO mice, consistent with a role of BID, not only upstream but also in parallel to BAX, BAK and BOK. Mitochondrial experiments identified a small cytochrome c‐releasing activity of full‐length BID. Collectively, these findings suggest a new effector role for BID in the intrinsic apoptosis pathway.
Простір та час у поезії Петра Борковця
Authors: Моторний Олександр 
Published: June 2022

Мета. У статті розглянуто образ часу та простору у творчості сучасного чеського поета Петра Борковця, редактора декількох чеських літературних періодичних видань, автора понад десяти збірок, тематикою яких є самотність людини, непорозуміння з навколишнім світом, пошук глибинного сенсу буття і які перекладені на більшість європейських мов, учасника різних поетичних фестивалів як у Чехії, так і в інших країнах, в тому числі і щорічного Місяця авторських читань, в рамках якого він відвідав Україну, перекладача світової поезії на чеську мову. Просторово-часові відносини загалом у поезії та у творчому доробку згаданого автора є одними з ключових, вони визначають поведінку ліричного героя, події у світі, в якому він перебуває, його взаємодію з цим світом, відношення вторинного поетичного світу до первинного людського, впливають на сприйняття твору читачем. Дослідницька методика. Хронотопний аналіз творів ліричного роду літератури. Результати. Встановлено особливості хронотопу поетичного світу П. Борковця, способи функціонування у творчості чеського автора феноменів минулого, теперішнього, майбутнього часу, явищ завмирання та розтягування часу або зникнення часового потоку, а також метаморфози просторових вимірів. Наукова новизна. Стаття присвячена розгляду новітнього явища поточного літературного процесу Чехії, яке ще не має досвіду власне наукового розгляду. Окрім того, творчість П. Борковця є для сучасного українського читача відносно новою, твори автора станом на сьогодні лише починають потрапляти до кола уваги вітчизняних перекладачів. Вказані фактори мають значення для збагачення та укріплення чесько-українських літературних і культурних зв’язків. Практичне значення. Матеріал статті може бути використаний у подальшому дослідженні творчості П Борковця, тенденцій розвитку новітньої чеської поезії, а також у викладання новітньої чеської літератури на філологічних спеціальностях вишів.
Expert Reception of The Limits to Growth: A Few Simple Tools for the Book Historian
Authors: Knott Cheryl 
Published: June 2022

In the early 1970s, a research team at the Massachusetts Institute of Technology used new methods of computer modelling to simulate global dynamic processes. The outcome of their work was a series of projections of the depletion of natural resources worldwide, with potentially dire consequences for the environment and the economy. Their report on their modelling and its projections was issued as a book in 1972, entitled The Limits to Growth. It created an immediate debate among scholars, policy makers, and other educated readers, and publications citing The Limits to Growth over its lifespan are voluminous. It continues to be cited 50 years after it was issued. The long citation period and the varied responses over time pose challenges for the book historian seeking to characterise the reception of the book. This article explores the ways in which book historians can use readily available citation analysis and visualisation tools to deepen understanding of a book’s reception beyond the qualitative methods typically used in the secondary literature. The Web of Science’s citation indexing and the HathiTrust collection’s full-text searching capability are used to identify articles and books that have cited or referred to The Limits to Growth. Examples of the visualisations generated from the search results in each are included as illustrations of simple, accessible tools that the lone book historian can use when the scale of his or her work does not require the kind of computational analytics created to parse big textual data in digital humanities projects.
Carnavalización y marginalidad en Los Dorados (1999) de Sergio Muñoz Chacón
Authors: Montero Rodríguez Shirley 
Published: June 2022

El presente artículo es un análisis de la narrativa costarricense de fin de siglo XX e inicios de siglo XXI, a través del texto Los Dorados (1999) de Sergio Muñoz Chacón. En primer lugar, se estudia la construcción discursiva de la posmodernidad literaria, a partir del proceso de carnavalización, según la propuesta teórica de Mijaíl Bajtín. En segunda instancia, se examina la marginalidad como discurso que permite la construcción simbólica del texto, desde las nociones de inversión y crisis. Finalmente, se observa el cuestionamiento crítico del discurso de la identidad nacional costarricense, en este texto narrativo finisecular.
Specifics of pelagic feeding by <i>Daphnia longiremis Sars</i> in the Kurile Lake in terms of structural transformation of phytoplankton
Authors: Lepskaya E. V. , Bonk T. V. 
Published: June 2022

Direct observations were used to study feeding by Daphnia longiremis Sars in the Kurile Lake (South Kamchatka) in terms of structural transformation of phytoplankton in 2008. Spectrum of the daphnia’s food reflects transformations in phytoplankton species structure. Daphnia’s consumption intensity of phytoplankton, where 99.8% were diatom cells, depends on the phytoplankton biomass. It is suggested, that daphnias meet deficient in food when the values of the phytoplankton (plankton diatoms) biomass are less than 48 mgС/m3 and no compensation of plankton bacteria or detritus.
An Investigation into the Home Environments of 10-14 Age Group Children in the Cognitive Maps
Authors: BURKUT Emine Banu , KÖSEOĞLU Emine 
Published: June 2022

Nowadays, urbanization is increasing and children’s relationship with their living environment
is becoming more and more important. This study aims to examine the urban
imagery elements in children’s minds concerning the urban space in which they live and
to show how children reflect spatial information about their home and home environment
in their cognitive maps. A field study was conducted with children (n=387) in the Kadıkoy
neighborhood of Istanbul during the fall semester of the 2021-2022 academic year. The
study group was selected using stratified random sampling. Questionnaires and cognitive
maps were created with children aged 10-14 years. IBM SPSS 25.0 statistical program
was used to analyze the research data. The study used descriptive data analysis to determine
frequencies and percentages. The results of the study are divided into two categories.
The first consists of drawing an image map of the real environment and determining the
image elements, and the second consists of spatially analyzing the content of the cognitive
maps drawn by the children. Spatial content analysis of cognitive maps; i) explanation of
home environment in children’s cognitive maps following Lynch’s methodology (path and
landmarks); ii) Matthews’ categories for classifying children’s drawn cognitive maps. The research findings show that i) paths are drawn more frequently as landmarks in children’s
cognitive maps, but landmarks are drawn in more detail and defined in writing. The second
finding of the study is ii) that the reflection rate of children’s functional cognitive map
drawings (elements of the built environment) from the immediate environment of their
home is quite high. This study of children’s city images and cognitive mapping abilities is
likely to give researchers in fields including city planning, architecture, educational sciences,
cognitive psychology, and child psychology a new perspective.