bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics of fluconazole after oral administration to healthy beagle dogs
Authors: Choi Yujin , Koo Yoonhoi , Yun Taesik , Chae Yeon , Lee Dohee , Jeong Jong‐Woo , Lee Kyeong‐Ryoon , Kim Hakhyun , Yang Mhan‐Pyo , Kang Byeong‐Teck 
Published: August 2022

AbstractBackgroundFluconazole can be effective in the treatment of superficial mycoses in dogs. However, the pharmacokinetics of fluconazole have not yet been evaluated to determine its optimal dosing regimen.ObjectivesThis study aimed to determine the plasma concentration of fluconazole after single and multiple administrations at two different dosages in dogs.Methods and materialsEight healthy beagle dogs were divided into two groups, and each group received either 5 or 10 mg/kg of fluconazole per os. The pharmacokinetics of fluconazole was determined following single and multiple administrations p.o. Single‐ and multiple‐dose treatment periods were separated by a washout period of seven days. Plasma concentrations of fluconazole were determined by established high‐performance liquid chromatography coupled with tandem mass spectrometry system.ResultsIn the 5 mg/kg group, the mean maximum concentrations (Cmax) and the area under the plasma concentrations (AUC0‐24h) were 4.84 μg/mL and 85.56 μg*h/mL, respectively, after single administration and 6.58 μg/mL and 119.52 μg*h/mL, respectively, after multiple administrations. In the 10 mg/kg group, the Cmax and AUC0‐24h were 5.67 μg/mL and 109.19 μg*h/mL, respectively, after single administration and 15.10 μg/mL and 291.51 μg*h/mL, respectively, after multiple administrations. The Cmax (p < 0.001) and AUC0‐24h (p < 0.001) were significantly lower in the 5 mg/kg group than those in the 10 mg/kg group at multiple administrations.Conclusions and clinical relevanceFluconazole accumulates in plasma and exhibits dose‐proportional pharmacokinetics after multiple doses, and was safe and well tolerated at these doses for short‐term administration.
Behavioral pain indicators for adults with an intellectual disability: a scoping review protocol
Authors: Gilliand Morgane , Perrenoud Béatrice , Lecerf Thierry , Serex Magali , Breaud Anne , Larkin Philip 
Published: August 2022

Objective:
This scoping review aims to identify and map the behavioral pain indicators observed when adults with an intellectual disability experience pain.

Introduction:
Adults with an intellectual disability have more health problems than the general population. The likelihood that this population will experience pain is high, but intellectual disability can obstruct the verbal expression of pain. Adults with an intellectual disability express pain via behavioral pain indicators; however, because no behavioral pain scale exists for this population, observers may misinterpret the pain experienced by adults with an intellectual disability.

Inclusion criteria:
The review will examine literature about behavioral pain indicators for adults with any type of intellectual disability who are suffering from any type of pain in any country or care setting.

Methods:
The review will be conducted according to the JBI recommendations for scoping reviews. A preliminary search focusing on the concepts of intellectual disability and pain measurement was conducted for PubMed and CINAHL in March 2022. Once the protocol is validated, searches will also be carried out in Embase, JBI EBP Database, the Cochrane Database of Systematic Reviews, ProQuest Dissertations and Theses, PsycINFO, Web of Science Core Collection, ERIC, Google Scholar, MedNar, and the websites of relevant professional associations. Titles and abstracts, and then full-text studies, will be selected independently by 2 researchers and assessed against the inclusion criteria. Relevant information will be imported into a data chart. Any behavioral pain indicators identified will be classified into 14 behavioral categories.

Review registration number:
Open Science Framework osf.io/8xckf
Dynamic Deformation Calculation of Articular Cartilage and Cells Using Resonance-Driven Laser Scanning Microscopy
Authors: Sibole Scott C. , Moo Eng Kuan , Federico Salvatore , Herzog Walter 
Published: August 2022

Abstract
The deformation of articular cartilage and its cells at the micro-scale during dynamic activities such as gait has high mechanoregulatory importance. Measuring the cellular geometries during such dynamics has been limited by the rate of microscopic image acquisition. The introduction of resonating mirrors for image rasterization (resonant scanning), rather than the conventional servo control (galvano scanning), has significantly improved the scanning rate by more than 100×. However, the high scanning rate comes at the cost of image quality, thereby posing challenges in image processing. Here, resonance-driven 3-D laser microscopy is used to observe the transient, micro-scale deformation of articular cartilage and its cells under osmotic challenge conditions. Custom image segmentation and deformable registration software were implemented for analysis of the resonance-scanned microscopy data. The software exhibited robust and accurate performance on the osmotic swelling measurements, as well as quantitative validation testing. The resonance-scanning protocol and developed analysis software allow for simultaneous strain calculation of both the local tissue and cells, and are thus a valuable tool for real-time probing of the cell–matrix interactions that are highly relevant in the fields of orthopedic biomechanics, cell mechanobiology, and functional tissue engineering.
Precision Silicon Exfoliation Tool Design
Authors: Ward Martin J. , Behera Dipankar , Cullinan Michael A. 
Published: August 2022

Abstract
The desire for thin-film silicon is motivated by the growing needs for flexible electronics, compact packaging, and advanced solar power. In previous work we have presented exfoliation as means to a cost effective way to achieve thin-film silicon and described an open loop prototype exfoliation tool that could be used to produce improved films compared to previous methods. However, controllable film thickness, film uniformity, and surface roughness were all challenges with the open loop setup. This paper describes the design, construction, and testing of an improved controlled exfoliation tool with load compensation and inline metrology for closed loop control of the exfoliation process. The exfoliation performance results are compared to those from the proof-of-concept tool and show 53% improvement in silicon uniformity and 67% improvement in average surface roughness. These improvements can be attributed to the addition of load compensation and the improvement in the precision motion of the stage, respectively.
New Left-Handed Milling Cutter and Process for Burrs-Free Machining of Precision Copper Electrode
Authors: Guo M. L. , Wei Z. C. , Gao H. , Zhang Z. H. , Jiang J. 
Published: August 2022

AbstractWith the increasing performance and appearance requirements of electronic products, higher standards have been put forward for the machining accuracy and quality of the precision copper electrode for product molds. The precision copper electrode is large in material plasticity and small in size. Burrs are easily generated during the cutting process, and subsequent cleaning is difficult. In this paper, according to the geometric features of the copper electrode, the distribution type and formation mechanism of burrs are deeply analyzed. The influence of cutting-edge geometry on burrs lateral dimension is investigated by simulation. Further, the new left-handed fillet milling cutter is designed that takes into account the simultaneous cutting of the end edge and the circumferential edge. Finally, based on the new milling cutter, burrs suppression machining process adapted to different geometric features is planned. Experiments show that the new cutter and process can greatly reduce the size of burrs and basically realize burrs-free machining compared with the conventional process of the ordinary right-handed milling cutter, and the service life of the new cutter is longer, which can meet the actual machining needs.
Embedded 3D Printing of PDMS-Based Microfluidic Chips for Biomedical Applications
Authors: Hua Weijian , Mitchell Kellen , Raymond Lily , Valentin Naima , Coulter Ryan , Jin Yifei 
Published: August 2022

Abstract
Microfluidic devices made from polydimethylsiloxane (PDMS) have diverse biomedical applications. However, due to the poor printability of PDMS, current 3D printing techniques are rarely used to fabricate microfluidic devices. This study aims to investigate a fumed silica-PDMS suspension that can function as a matrix bath for embedded 3D printing (e-3DP) purposes, making it technically feasible to print microfluidic chips with complex embedded channels via low-cost extrusion 3D printing. The rheological properties, mechanical properties, transparency, and filament fidelity of the fumed silica-PDMS suspension have been systematically studied. It is found that the addition of fumed silica particles can effectively change PDMS from a viscous solution to a yield-stress suspension with suitable rheological properties for e-3DP. Also, the mechanical properties of the crosslinked fumed silica-PDMS are enhanced with an increased concentration of fumed silica. Although the transparency of PDMS has been lessened by mixing it with fumed silica particles, the visibility of the printed microfluidic chips is still acceptable. The filament fidelity has been studied by embedded printing filaments using a sacrificial ink in the fumed silica-PDMS suspension. Finally, two representative microfluidic chips for biomedical applications have been successfully printed to validate the effectiveness of the proposed fumed silica-PDMS suspension-enabled e-3DP method.
Validation of Feedback Reactivity Evaluation Models for Plant Dynamics Analysis Code During Unprotected Loss of Heat Sink Event in Sodium-Cooled Fast Reactors
Authors: Yoshimura Kazuo , Doda Norihiro , Igawa Kennichi , Tanaka Masaaki , Yamano Hidemasa 
Published: August 2022

Abstract
Feedback reactivity caused by core deformation is one of the inherent safety features in a sodium-cooled fast reactor (SFR). To validate the evaluation models of the reactivity feedback equipped in the in-house plant dynamics analysis code, named Super-COPD, we have been conducting the benchmark analyses for the unprotected loss of heat sink (ULOHS) tests of balance of plant (BOP)-302R and BOP-301 as one of the representative issues in Experimental Breeder Reactor-II (EBR-II), a pool-type experimental SFR in the United States. During the transient of the ULOHS tests, the reactor power decreased to the decay heat level due to the negative reactivity caused by the radial expansion of the core. Developing the evaluation models of the reactivity feedback is essential for predicting the plant behavior in unprotected events, such as ULOHS events, and the numerical analyses modeling the feedback reactivity were conducted. By comparing the numerical results and the experimental data, the increment temperature profiles of the core inlet and the decreasing reactor power profile calculated by Super-COPD were comparable with experimental data. The applicability of the evaluation models for the reactivity feedback was indicated during the ULOHS event. In addition, through the sensitivity analyses on the cold pool model, it was found that the modification of the plenum model of the cold pool to take into account the thermal stratification was required to improve the core inlet temperature profile.
Convective Performance of C5-Flouroketone-Based (C5-FK) and C4-Flouronitrile-Based (C4-FN) Gas Mixtures and SF6
Authors: Korbel J. , Ostrowski J. , Stoller P. , Agostini F. , Braun T. , Bujotzek M. , Richter M. 
Published: August 2022

Abstract
SF6 is a widely used insulating gas in the electric power industry due to its high dielectric strength. However, SF6 is classified as a greenhouse gas and has a very high global warming potential (GWP). Much research and development efforts have focused on finding alternatives to SF6 which have a lower GWP. An important requirement for an SF6 alternative is that it has similar heat transport properties to SF6, since one aspect of the design of high voltage equipment is the management of the heat dissipated from the flow of current. In the present paper, we compare the convective performances of SF6 and C5-flouroketone (C5-FK) and C4-flouronitrile (C4-FN) based gas mixtures. Mixtures of CO2, O2, and C5-FK/C4-FN have a GWP much smaller than that of SF6, a high dielectric strength, are not classified as toxic, and have good arc interruption properties. The numerical study is based on a semi-coupled computational electromagnetics (CEM) and computational fluid dynamics (CFD) analyses. The results of the numerical study are compared with experiments. There is a good agreement between the simulation results and the experiments. C5-FK and C4-FN based gas mixtures have good convective performance and are well-suited for application in circuit breakers. Thus, from the temperature-rise point of view, C5-FK and C4-FN based gas mixtures represent an alternative to the SF6 insulating gas traditionally used.
Associations of Accelerometer-Measured Physical Activity and Sedentary Time With All-Cause Mortality by Genetic Predisposition for Longevity
Authors: Posis Alexander Ivan B. , Bellettiere John , Salem Rany M. , LaMonte Michael J. , Manson JoAnn E. , Casanova Ramon , LaCroix Andrea Z. , Shadyab Aladdin H. 
Published: August 2022

The goal of this study was to examine associations between accelerometer-measured physical activity (PA) and sedentary time (ST) with mortality by a genetic risk score (GRS) for longevity. Among 5,446 women, (mean [SD]: age, 78.2 [6.6] years), 1,022 deaths were observed during 33,350 person-years of follow-up. Using multivariable Cox proportional hazards models, higher light PA and moderate to vigorous PA were associated with lower mortality across all GRS for longevity categories (low/medium/high; all ptrend < .001). Higher ST was associated with higher mortality (ptrend across all GRS categories < .001). Interaction tests for PA and ST with the GRS were not statistically significant. Findings support the importance of higher PA and lower ST for reducing mortality risk in older women, regardless of genetic predisposition for longevity.
A Practical Approach to Negotiating Authorship and Preparing Manuscripts for Publication
Authors: Richards Kevin Andrew , Hemphill Michael A. , Flory Sara B. 
Published: August 2022

The academic publishing process is fraught with challenges, inconsistencies, and the absence of clearly articulated guidelines and recommendations, particularly for doctoral students and other newcomers. Our goal is to overview key information that authors may consider and decisions they will need to make when determining authorship and preparing manuscripts for submission. Specifically, we discuss how authors can consider (a) the ongoing discussion of authorship, (b) identifying a target journal, and (c) submitting a manuscript for review. We draw influence from how processes are conducted relative to the Journal of Teaching in Physical Education in approaching our commentary as a point of reference. Nevertheless, while acknowledging differences in journal style and submission formats, many of the considerations discussed are relevant across publication outlets. Common threads across the discussion impress the importance of being intentional, proactive, and adaptive when engaging in authorship conversations and identifying target journals for submission.
Newtonian Cosmology and Relativistic Theory
Authors: Novikov I. D. , Novikov I. D. 
Published: August 2022

Abstract
This paper refutes the erroneous statements that arose in theoretical cosmology almost 90 years ago. The method accepted in the literature for deriving the local properties of the Friedmann cosmological model, using only Newton theory, without resorting to Einstein theory, is considered. We showed that the usual method of such inference is not sufficient to obtain the correct result, and leads to errors. Requirements are formulated that are sufficient for the Newtonian model to really be an approximation to the relativistic theory.
Temporal trend of first-ever ischaemic stroke incidence from 2010 to 2019 in South Korea: a nationwide retrospective cohort study
Authors: Lee Jeehye , Kim Hyeongsu , Moon Jusun , Shin Jinyoung , Jeong Hojin , Kim Youngtaek 
Published: August 2022

ObjectiveIschaemic stroke incidence is on the decline globally, but the trend in South Korea is unknown. In this study, the 10-year incidence trends of first-ever ischaemic stroke in South Korea were evaluated.Design, setting and participantsThe National Health Insurance Services medical claim data were used to construct 10 annual cohorts of adults aged 20 years and older, who had not been diagnosed with stroke, to find out the incidence trends of first-ever ischaemic stroke from 2010 to 2019.Outcome measuresThe primary outcomes were crude and age-adjusted incidence rates for 10 years. Crude incidence rates of the age groups and incidence age statistics were calculated. For comparison among the income groups, age-adjusted incidence rates were used. Incidence rates in all the groups were analysed separately by sex.ResultsAge-standardised incidence rates of ischaemic stroke per 100 000 were 101.0 in men, and 67.6 in women in 2010; and 92.2 in men, and 55.0 in women in 2019. By age group, there was a decrease in women over 40 years of age, and men over 60 years of age. The relative difference in stroke incidence rates between medical aid beneficiaries and the highest income group increased from 1.5 to 1.87 over 10 years.ConclusionsAge-standardised incidence rate of ischaemic stroke has decreased from 2010 to 2019 for both man and women. The incidence rate was stable in the younger age groups and decreased in the older age groups, and the disparities between income groups have widened over the past decade. Stroke prevention strategies are needed for the younger age group and the low-income group. Further research is needed to study the risk factors contributing to the incidence of ischaemic stroke in different groups.
Healthcare professionals’ perceptions and experiences of physiotherapy for people with mental illness: a protocol for a systematic review and meta-ethnography
Authors: Hemmings Laura , Heneghan Nicola R , Byrd Erin , Stubbs Brendon , Soundy Andrew 
Published: August 2022

IntroductionThere is a high global prevalence of patients presenting with physical and mental health comorbidities. Physiotherapeutic interventions, such as exercise, can have positive benefits for physical and mental health. However, poor accessibility and negative experiences of healthcare services for those with mental illness (MI) have been consistently observed within literature with recent research identifying poor experiences of physiotherapeutic interactions and processes such as referrals and discharges. One way to help improve physiotherapy services for this population is to understand the personal experiences and perceptions of healthcare professionals (HCPs) toward physiotherapy for patients with MI. Qualitative-based evidence syntheses are suited to bring this data together with the aim of improving physiotherapy services for patients with MI. This review will systematically search and synthesise existing evidence around HCP experiences and perceptions of physiotherapy for people with MI.Methods and analysisA systematic search and seven-phase meta-ethnography will be undertaken. A comprehensive search of electronic databases (CINAHL plus, MEDLINE, Pubmed, Embase and Psycinfo) and search engines as well as grey literature (unpublished primary research such as theses) will be completed. Searches are planned to take place in July 2022. Eligibility criteria include: (a) qualitative data, (b) perceptions identified from HCP, including physiotherapists, assistants and HCP referring into physiotherapy, about physiotherapy for patients with MI and (c) are primary studies.Ethics and disseminationThis work is exempt from requiring ethical approval due to review methodology with data accessed from published works. This systematic review is expected to provide insight into experiences and perceptions of HCP around benefits and barriers to accessing physiotherapy for patients with mental health illness. Findings will be used to inform further research and co-develop recommendations to overcome barriers and optimise facilitators to care for this population. Findings will be disseminated via peer-reviewed journal, conference presentations and to key stakeholder groups.PROSPERO registration numberCRD42021293035.
Examining the discourse regarding the delivery of occupational infection prevention and control training to healthcare workers: a scoping review of pandemic plans of 23 countries
Authors: Qureshi Mohammmed Owais , Chughtai Abrar Ahmad , Islam M Saiful , Tuckerman Jane , Seale Holly 
Published: August 2022

BackgroundOver the years, countries reformed their pandemic plans but still healthcare systems were unprepared to handle the COVID-19 pandemic. Throughout the COVID-19 pandemic, healthcare workers (HCWs) raised issues around shortage of personal protective equipment (PPE), inadequate occupational infection prevention and control (IPC) training, lack of guidance regarding reuse/extended use of PPE and absence of HCWs.ObjectiveThe objective of this scoping review was to compare national and transnational pandemic plans and COVID-19 guidelines for the inclusion of recommendations regarding pandemic-specific occupational IPC training for HCWs, as well as strategies for managing the surge in PPE needs and staffing.Inclusion criteriaFrom each of the six WHO defined world regions, four countries with the highest burden of COVID-19 cases (as of mid-2020) were selected and attempted to locate the relevant pandemic plans and COVID-19 guidelines.MethodsSearches were undertaken of 1: National Guidelines Clearinghouse, 2: websites of international public healthcare agencies such as WHO, the European Centre for Disease Prevention and Control (ECDC) and, 3: in-country health departments/Ministry of Health/Department of Public Health, between June 2020 and July 2021. The data were summarised under six themes drawn from publicly available pandemic plans and COVID-19 (IPC) guidelines of WHO, ECDC and 23 countries.ResultsThe WHO, ECDC and 14 countries reported pandemic-specific IPC training; however, only four discussed training HCWs on correct PPE use; six countries listed strategies to manage the surge in demand of HCWs, while only five discussed managing the shortage of PPE. None of the COVID-19 guidelines recommended training HCWs for correct reuse or extended use of PPE and only one country’s guideline outlined mandatory HCWs attendance and delivery of training in a regional language.ConclusionPandemic plans should be revised to include guiding principles regarding the delivery of pandemic specific IPC training. There is also a need to provide guidance on when countries should consider reuse and extended use of PPE. This discourse should also be reflected in disease-specific pandemic guidelines, like COVID-19 (IPC) guidelines. The aim of this review is to assist international health agencies in generating evidence-based guideline updates.