bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive lymph nodes predict distant metastasis of salivary duct carcinoma after postoperative radiotherapy
Authors: Yan Wenbin , Ou Xiaomin , shen chunying , Hu Chaosu 
Published: March 2022

Abstract
Purpose
Salivary duct carcinoma (SDC) is a high-grade subtype of salivary gland malignancy. Distant metastasis was the common pattern of failure for patients receiving surgery and adjuvant radiotherapy. We are aimed to analyze the prognostic value of positive lymph nodes for distant metastasis in the SDC following postoperative radiotherapy.
Patients and Methods
: We reviewed the data of patients with SDC receiving surgical resection and radiotherapy. The univariate analysis was conducted using Log-rank method for the clinicopathological features with distant-metastasis-free survival (DMFS). The multivariable analysis was performed by Cox regression hazards method. A risk stratification model was established by the score calculated with the variables qualified by multivariate P < 0.05.
Results
91 patients were enrolled, and the median age at diagnosis was 58.5 years. 53.8%(n = 49) of the patients appeared with the involvement of neck lymph nodes after surgery. The advanced T stage (95% CI 1.325–5.38; P = 0.006), number of positive lymph nodes (PLN ≥ 8) (95% CI 1.241–6.58; P = 0.013), and peripheral invasion (PNI) (95% CI 1.059–4.65; P = 0.034) were significantly associated with DMFS for the SDC in the multivariate analysis. Patients were divided into two subgroups based on the risk factors, while significant differences of DMFS and OS were observed between the risk cohorts (5-year DMFS:35% vs.64.4%, P = 0.0001; 5-year OS:53.6% vs.70.4%; P = 0.048).
Conclusion
Higher number of positive lymph nodes was associated with worse DMFS in SDC following PORT. The patients at high risk appeared with significantly poor DMFS and survival, and clinical trials on adjuvant therapy are warranted for this subgroup.
An experimental electro-thermo-mechanical characterization of plastic deformation of quenched and tempered pipe steel for oil country tubular goods
Authors: Saberi Saeid , Weiss Helmut , Winter Gerald , Klarner Jürgen , Stockinger Martin 
Published: March 2022

Abstract
Development, manufacturing, and optimization of Oil Country Tubular Goods (OCTG) are strongly related to thermo-mechanical behavior of quenched and tempered pipe steels. Threaded pipe connections consist of a pipe end with external thread (pin) and coupling with the internal thread (box). They are manufactured on seamless pipes made of typical OCTG steel grades like P110. Introduced residual stresses in the threaded connections due to cold preforming process as well as tension/ compression and torsion make-up tests lead to material degradation of the pipe steel. The complex geometry of thread and difficult access to the thread surface make conventional methods for residual stress measurement impossible. In this study, in-situ measurement of the strain, the temperature and the electrical resistivity of steel P110 during electro-mechanical coupled uniaxial tensile test was performed. The electro-thermo-mechanical properties of the investigated material were determined using a Matlab® code. The presented experimental method could be used for the experimental in-situ measurement of local plastic strains in threaded connections under make- up tests. Inanition, the obtained results of this research such as electro-thermo-mechanical properties of investigated pipe steel could be applied for material modelling of pipe steels.
Taxonomic study of polymorphic basidiomycetous fungi Sirobasidium and Sirotrema: Sirobasidium apiculatum sp. nov., Phaeotremella translucens comb. nov. and rediscovery of Sirobasidium japonicum in Japan
Authors: Degawa Yousuke , Endoh Rikiya , Masumoto Hiroshi , Yoshihashi Yuma , Ohkuma Moriya , Degawa Yousuke 
Published: March 2022

Abstract
Species in the genera Sirobasidium and Sirotrema (Tremellales, Tremellomycetes, Agaricomycotina, Basidiomycota) were described based on the morphology of teleomorph, and many of them lack both isolates of anamorphic yeast state and nucleotide sequence data. Strains of Sirotrema translucens and Sirobasidium japonicum were established for the first time from basidiocarps collected in Japan. Also, an undescribed species in the genus Sirobasidium was isolated. Molecular phylogenetic analysis based on the sequences of D1/D2 region of large subunit ribosomal RNA gene (LSU D1/D2), ITS-5.8S ribosomal RNA gene (ITS), and small subunit ribosomal RNA gene (SSU) showed that St. translucens, which has been considered to be related to the genus Sirobasidium based on its basidial ontogeny, was placed in a phylogenetically separated clade including the genus Phaeotremella. The analysis also revealed that Sirobasidium sp. and Sb. japonicum, previously assumed to have a close affinity to the order Auriculariales, were members in the Tremellales. Sirobasidium sp. was characterised by its apiculate epibasidia and 2-celled basidia, which is a unique combination of characteristics in the genus. In conclusion, we keep Sirobasidium japonicum in the Tremellales and propose Sirobasidium apiculatum sp. nov. and Phaeotremella translucens comb. nov.
The effect of goal-directed crystalloid versus colloid administration on postoperative pulmonary function: A substudy of a randomized controlled clinical trial
Authors: Obradovic Mina , Luf Florian , Reiterer Christian , Schoppmann Sebastian , Kurz Andrea , Fleischmann Edith , Kabon Barbara 
Published: March 2022

Abstract
Background: Pulmonary function is impaired after major abdominal surgery and might be improved by restrictive fluid administration. Under the assumption of a fluid sparing effect of colloids we tested the hypothesis that an intraoperative colloid-based goal-directed fluid management strategy improves postoperative pulmonary function parameters compared to goal-directed crystalloid administration. Methods: We performed a preplanned, single-center substudy within a recently published trial evaluating the effect of goal-directed crystalloids versus colloids on a composite of major complications. 60 patients undergoing major open abdominal surgery were randomized to Doppler-guided intraoperative fluid replacement therapy with lactated Ringer’s solution (n = 31) or 6% hydroxyethyl starch 130/0.4 (n = 29). A blinded investigator performed bedside spirometry (Spirobank-G, Medical International Research; Rome, Italy) preoperatively as well as 6-, 24-, and 48 hours postoperatively. Results: Median total intraoperative fluid requirements were significantly higher during crystalloid administration compared to patients receiving colloids (4567 ml vs. 3044 ml, p = 0.01). 6 hours after surgery pulmonary function parameters did not differ significantly between the crystalloid - and the colloid group: forced vital capacity (FVC): 1.6 l (1.2 - 2 l) vs.1.9 l (1.5 - 2.4 l), p = 0.15; forced expiratory volume in 1 second (FEV1): 1.1 l (0.9 - 1.6 l) vs. 1.4 l (1.2 - 1.7 l), p = 0.18; peak expiratory flow (PEF): 2 l.sec -1 (1.5 - 3.6 l.sec -1) vs. 2.3 l.sec -1 (1.8 - 3.4 l.sec -1 ), p = 0.23. Similarly, postoperative time weighted averages of FVC (p = 0.50), FEV1 (p = 0.96) and PEF (p = 0.39) did not differ significantly. Conclusion: Intraoperative goal-directed colloid administration did not significantly improve postoperative pulmonary function parameters in patients undergoing open abdominal surgery compared to goal-directed crystalloid administration.Trial Registration: ClinicalTrials.gov (NCT00517127, registered on August 16th, 2007, https://clinicaltrials.gov/ct2/show/NCT00517127) and EudraCT (2005-004602-86)
Nonparametric inference for the reproductive rate in generalized compartmental models
Authors: Trejo Imelda , Lin Yen Ting , Patrick Amanda Louise , Hengartner Nicolas 
Published: March 2022

Abstract

We develop a tractable non-parametric model for the time-varying reproductive rate of infectious diseases that combines the structure of a deterministic compartmental model and a stochastic model for incidence data. We use Bayesian inference to estimate, with uncertainty, the reproductive rate of the Coronavirus 2019 outbreak in the U.S. states of California, Florida, Michigan, New Mexico, New York, and Texas from January 2020 to March 2022. We use the inferred reproductive rates to estimate the posterior distribution of the time-varying reproduction numbers for each state. Compering the time-varying reproduction numbers across the states, we identify some epidemic waves, potentially driven from changes in human behavior and virus mutations.
Analysis of palmar hyperhidrosis using thermal image-based heat of evaporation
Authors: Lee Jiwon , Lee Onseok 
Published: March 2022

Abstract
The condition of hyperhidrosis, which may impair one's quality of life depending on the degree of discomfort, is characterized by excessive sweating. Clinicians mainly use patient histories and questionnaires to diagnose palmar hyperhidrosis. In cases of high severity, hyperhidrosis is diagnosed through infrared thermal imaging; however, it is evaluated based on the clinician's knowledge and experience. Therefore, we intend to present an objective diagnostic method that uses a quantitative approach as an alternative to the subjective evaluation for diagnosing diseases such as hyperhidrosis. In this study, the heat of palmar evaporation was quantified and analyzed from thermal images. The higher the water in the evaporating process of residual heat from body temperature and sweat, the slower is the diffusion, and hyperhidrosis can be diagnosed depending on the degree of diffusion. The analyzed data were used as classifier training data to diagnose the state of sweating. K-nearest neighbors, one of the classifiers used, showed the best performance with 98% accuracy. This study quantitatively presents the criteria for determining the injection site for drug treatment of palmar hyperhidrosis, and can be presented as a new diagnostic evaluation method for thermal imaging-based palmar hyperhidrosis based on the phenomenon of evaporation.
Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
Authors: Kwon Sunghoon , Lee Amos , Lee Yongju , Choi Ahyoun , Lee Han-Byoel , Shin Kyoungseob , Lee Hyunho , Kim Ji Young , Ryu Han Suk , Kim Hoe Suk , Ryu Seung Yeon , Lee Sangeun , Cheun Jong-Ho , Yoo Duck Kyun , Lee Sumin , Choi Hansol , Ryu Taehoon , Yeom Huiran , Kim Namphil , Noh Jinsung , Lee Yonghee , Kim Inyoung , Bae Sangwook , Kim Jinhyun , Lee Wooseok , Kim Okju , Jung Yushin , Kim Changhoe , Song Seo Woo , Choi Yeongjae , Chung Junho , Kim Byung Gee , Han Wonshik 
Published: March 2022

Abstract
Epitranscriptomic features, such as single-base RNA editing, are sources of transcript diversity in cancer, but little is understood in terms of their spatial context in the tumour microenvironment. Here, we introduce spatial-histopathological examination-linked epitranscriptomics converged to transcriptomics with sequencing (Select-seq), which isolates regions of interest from immunofluorescence-stained tissue and obtains transcriptomic and epitranscriptomic data. With Select-seq, we were able to analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer (TNBC) patients. We identified alternative splice variants, performed complementarity-determining region analysis of infiltrating T cells and B cells, and assessed adenosine-to-inosine (A-to-I) base editing in tumour tissue sections. Especially, in TNBC microniches, A-to-I editome specific to different microniche groups was identified.
‘ Triple Clear’: A systematic and up-to-date surgical process for Campanacci grades II and II giant cell tumours of bone, with or without pathological fracture and joint invasion
Authors: Wang Yushan , Tian Qiaoqiao , Li Haoze , Li Jian , Ren Peng , Lv Zhi , Lv Jia , Bai Junjun , Feng Yi 
Published: March 2022

Abstract
Background: 1) To describe a systematic process for giant cell tumours of bone (GCTB). 2) To compare the clinical effects of ‘triple clear’ (TC) and segmental resection (SR), bone grafts and bone cement.Method: Patients with Campanacci grades II and III primary GCTB who were treated with either SR (n = 39) or TC (n = 41) were included. The pain level was determined by the Visual Analogue Scale. Limb function was determined by the Musculoskeletal Tumour Society (MSTS) score.Result: The operation time was 135.7±38.4 min in the TC group and 174.2±43.0 min in the SR group (P<0.05). The recurrence rates were 7.3% in the TC group and 10.0% in the SR group (P = 0.37). The MSTS scores at three months after surgery were 19.8±1.5 in the TC group and 18.8 ±1.5 in the SR group. The MSTS scores at two years were 26.3±0.7 in the TC group and 24.2±1.6 in the SR group (P<0.05). Conclusion: TC is recommended for patients with Campanacci grade II-III GCTB and for those with GCTB accompanied by pathological fracture or joint invasion. Bone grafts may be more suitable than bone cement in the long term.
Biochemical cartilage alteration in T2 mapping in knee joints of amateur marathon runners before and after competition
Authors: Zheng Weipeng , WU Xiaohang , Zhang Yanwei , Zhao Guoyuan , Wei Hewei , Wan Lei , Zhao Guoyuan , Hu Weijian , Fang Weihua 
Published: March 2022

Abstract
To evaluate changes in knee articular cartilage of amateur marathon runners using magnetic resonance imaging T2 relaxation time mapping. T2 mapping was performed in 18 non-professional male marathon runners 48 h before and 72 h after a marathon. Bulk and zonal tibiofemoral T2 mapping were assessed. T2 mapping values of the left knees (LK) decreased after competition (48.45±25.08 versus 39.75±18.91 ms), while those of the right knees (RK) were similar before and after the marathon. Significant increases in mean T2 relaxation times were observed in the RK medial femoral condyle (42.14±8.96 versus 53.63±3.664 ms). There were significant decreases in T2 relaxation time in the LK medial tibial plateau (50.01±30.25 versus 33.99±7.25 ms), LK lateral tibial plateau (44.64±19.84 versus 29.62±9.76 ms), LK lateral femoral condyle (54.72±32.94 versus 44.75±16.61 ms), and RK lateral tibial plateau (42.93±16.91 versus 35.51±16.20 ms). No significant changes were observed in the LK medial femoral condyle, RK medial tibial plateau, and femoral condyle. Regional analyses showed lower T2 mapping values in the L2, R2, L5, R5, L8, and R8 points on both knees after competition. Changes in T2 mapping values can reflect alterations in cartilage structures. As an extreme endurance sport, marathons can damage the local cartilage of knee joints of non-professional marathon athletes shortly after exercise. However, this effect is small and probably not clinically relevant.
Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Authors: Borghammar Camilla , Tamaddon Ashkan , Erfurth Eva-Marie , Sundgren Pia C , Siesjö Peter , Elfving Maria , Nilsson Margareta 
Published: March 2022

Abstract
Purpose
No consensus exists regarding follow-up recommendations for suspected pituitary microadenoma in children. To address this knowledge gap, we investigated the growth potential of pituitary solid and cystic lesions < 10 mm in children and evaluated the accuracy of magnetic resonance imaging (MRI) measurements.
Methods
The children included were < 18 years at first pituitary MRI and radiologically diagnosed with a non-functioning microadenoma or cyst < 10 mm. Lesion size at first and latest MRI as well as all individual MRI examinations were re-evaluated.
Results
In total, 74 children, median age 12 years (range 3–17), had a non-functioning microadenoma, probable microadenoma, or cyst. Of these, 55 underwent repeated MRI (median 3, range 2–7) with a median follow-up of 37 months (range 4–189). None of the pituitary lesions without hormonal disturbances increased significantly during follow-up. Two radiologists agreed that no lesion could be identified in 38/269 (14%) MRI examinations, and in 51/231 (22%) they disagreed about lesion location. In 34/460 (7%) MRI measurements size differed > 2 mm, which had been considered significant progression.
Conclusion
Non-functioning pituitary microadenoma in children has small size variations, often below the spatial resolution of the scanners. We suggest lesions < 4 mm only for clinical follow-up, lesions 4–6 mm for MRI after 2 years and ≥ 7 mm MRI after 1 and 3 years, with clinical follow-up in between. If no progression, further MRI should only be performed after new clinical symptoms or hormonal disturbances.
Variations in the use of malaria preventive measures among pregnant women in Guinea. A secondary analysis of the 2012 and 2018 demographic and health surveys.
Authors: BARRY Ibrahima , TOURE Almamy Amara , SANGHO Oumar , BEAVOGUI Abdoul Habib , CISSE Diao , DIALLO Abdourahamane , MAGASSOUBA Aboubacar Sidiki , SYLLA Younoussa , DOUMBIA Lancina , CHERIF Mahamoud Sama , CAMARA Alseny Yarie , DIAWARA Fatou , TOUNKARA Moctar , DELAMOU Alexandre , DOUMBIA Seydou 
Published: March 2022

Abstract
Introduction Despite its effectiveness, the optimal use of the combination of insecticide treated nets (ITN) and intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (TPIg-SP) remains low in malaria endemic areas. Therefore, we studied its variations and predictors in Guinea.MethodsWe conducted a secondary analysis of the 2012 and 2018 Guinea Demographic and Health Surveys (DHS). It included women who had given birth in the 3 years before each DHS, slept on ITN and took at least one dose of SP. Moran indices were used to determine spatial autocorrelation. A logistic regression and classification and regression tree (CART) identified the predictors of malaria preventive measures (MPM).ResultsIn 2012, 60.88% of pregnant women used MPM incompletely compared with 79.11% in 2018. Associated factors with incomplete MPM in 2012 were as follows: having an indirect link with the head of household (AOR = 2.23, 95% CI 1.08–4.61) and performing at least 4 ANCs (AOR = 0.66, 95% CI 0.44–0.99). In 2018 : live in households of 2 to 5 people (AOR = 0.54, 95% CI 0.36–0.80), have a man as the head of the household (AOR = 0.56, 95% CI 0.35–0.89), perform the first ANC in the second quarter (AOR = 0.74, 95% CI 0.54–0.99), perform at least 4 ANCs (AOR = 0.47, 95% CI 0.36–0.62), have a job (AOR = 0. 67, 95% CI 0.50–0.88), give birth in a public health facility (AOR = 0.53, 95% CI 0.39–0.72) and the middle wealth quintile (AOR = 1.56, 95% CI 1.07–2.26). A global autocorrelation (I Moran=0.0009, p = 0.2349) and high-high clusters were found in Mamou in 2012. In 2018, autocorrelation was found (I Moran=0.0169, p ≤ 0.05), with spatial clusters in regions of Boké, Mamou, Labé, and N’Zérokoré.ConclusionComplete use of MPM during pregnancy remains still low throughout years in Guinea. Strategies toward familial and healthsystem levels should be implemented and monitored, to reduce inequality in the use of MPM. In this regard, Mamou region deserves more attention.
Bushfire prediction in Victoria, Australia using Generalized extreme value distribution
Authors: Khastagir Anirban , Hossain Iqbal , Aktar Nazneen 
Published: March 2022

Abstract
To facilitate appropriate design, management, and improvement of infrastructures for both rural and urban communities, the prediction for the occurrence of future extreme climatic events e.g. bushfire is intrinsic. Widely used extreme climatic event prediction method, Generalized Extreme Value (GEV), was used in this study in predicting annual peak Forest Fire Danger Index (FFDI), which is a measure of fire behaviour used in different parts of Australia. The GEV distribution was fitted for 17 selected stations spreading all around Victoria, Australia. The estimation of the parameters for the GEV distribution was performed using Maximum Likelihood Estimation (MLE) method. Three goodness of fit tests such as: Kolmogorov-Smirnov (KS) test, Anderson-Darling (AD) test, and Chi-square test result were used to verify the efficacy of GEV distribution. Fire frequency curves (FFCs) were derived for Victoria to identify fire prone regions. The study revealed that Fréchet (type II) extreme value distribution is suitable for modelling the annual peak of FFDI for most of the selected stations. Annual peak FFDI for the 100 years return level (time average of every 100 years) can vary from 34 (Dartmouth) i.e. high fire danger event to 146 (Walpeup) i.e. catstrophic bushfire event. The study noted that three stations in Victoria namely: Nhill, Walpeup and Ouyen are vulnerable to catastrophic fire danger situation (FFDI ≥100) with at least 1% probability of occurrence (1 in 100 year). The developed FFCs for Victoria will guide key public and private stakeholders namely: catchment management authorities, insurance companies, structural designers, traffic modellers, and forest hydrologists when designing and managing infrastructures in fire prone areas.
Preoperative lower limb skeletal muscle mass impact functional rehabilitation and mobility ability after total knee arthroplasty for osteoarthritis: a prospective, observational study
Authors: Yang Ling-Li , Fan Yang , Wang Zi-Ming , Cen Yuan , Xiong Yan , Ren Hui 
Published: March 2022

Abstract
Background
Despite the remarkably successful treatment of total knee arthroplasty (TKA), several patients also dissatisfied with their function, not met preoperative expectations. The purpose of this study was to investigate the relationship between preoperative lower limb skeletal muscle mass (LSM) and early functional rehabilitation outcome after TKA.
Methods
102 patients who underwent a primary unilateral TKA were enrolled to our prospectively observational study. Preoperative variables included demographic (socio-demographic data and disease-related information), LSM, lower limb muscle strength. The HSS and WOMAC-Function scales was used to evaluate knee functional rehabilitation outcome and mobility ability at the time points of preoperative, 3 months and 6 months after TKA. Univariate and multivariate regression analysis was performed with the evaluations at 6 months after TKA as the main outcome measures.
Results
Multivariate Logistic regression analysis showed that LSM (β = 4.367, p = 0.000) was positively related to functional rehabilitation measured by HSS at 6 months postoperatively; age (β=-0.104, p = 0.007), postoperative pain (β=-1.311, p = 0.000) were negatively related to HSS. The preoperative lower limb skeletal muscle mass showed a significant negative relationship with the postoperative functional activity ability assessed by WOMAC-Function scale (β=-0.208, P = 0.006).
Conclusion
Lower limb skeletal muscle mass positively impacted on functional rehabilitation and knee mobility ability after TKA in patients with osteoarthritis. LSM should be considered when considering patient`s expectation to achieve higher demanding tasks.