bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile Approach to Fabricate Oriented Porous PDMS Composites for Movements Monitoring and Identifying Motion Patterns
Authors: Li Shenglin , Hu Xintong , Zuo Shuangshuang , You Tianquan , Du Yangyang , Bu Ze , Mao Guoliang , Wang Jianhua , Song Shiqiang , Zhang Yong 
Published: November 2022

AbstractThe facile and rapid fabrication of oriented porous polymers is crucial for flexible pressure sensors. Herein, a pressure sensor is developed based on oriented porous polydimethylsiloxane (PDMS) composites for detecting human motion and identifying joint motion patterns. The oriented porous PDMS composite is first constructed through thiol‐ene click chemistry and directional freezing within only 30 min, then fabricated by interfacial in situ polymerization of dopamine and pyrrole to generate robust interfaces. As a result, the as‐prepared oriented porous PDMS composite is assembled into a pressure sensor that shows potential applications in pressure and human motion detection. Interestingly, a sensor assembled by orthogonally stacking the PDMS composites can be used for joint motion pattern recognition with potential monitoring of football motion due to their directional structures. This facile strategy coupled with the oriented porous structure is expected to help design advanced wearable electronic devices.
Processing Properties and Thermal Stability of Poly(vinyl chloride‐co‐vinyl acetate) by Experiments and Molecular Dynamics Simulations
Authors: Li Runyue , Lin Daolei , Xu Shiqin , Chen Xingzheng , Tian Guofeng , Wu Dezhen 
Published: November 2022

AbstractThe effects of copolymerized monomer vinyl acetate (VAc) on processing properties and thermal stability of poly(vinyl chloride‐co‐vinyl acetate) (PVCA) are investigated via experiment and molecular dynamics simulation. Experimental results showed that PVCA with higher VAc content has larger loss tangent (tanδ), lower complex viscosity (η*), and glass transition temperature (Tg), which improved the processing properties of PVCA. A series of PVCA models are constructed to study the microstructure on the processing properties of PVCA, and the results showed the PVCA with higher VAc content exhibits larger molecular chain mobility and free volume fraction (FFV), smaller intermolecular interactions, and the mean square end‐to‐end distance (<Ree2>). Furthermore, the IR spectra of gas products indicated that thermal degradation of PVCA mainly generated hydrogen chloride (HCl), carboxylic acid, and aliphatic hydrocarbons between 200 and 500 °C, and the removal of HCl and carboxylic acid is almost simultaneous. The degradation models of PVCA chains demonstrated the CCl bond in vinyl chloride (VC) and CO bond in VAc have similar thermal stability, which corresponded to the experimental results. In a word, the work provides a promising technique to study the structure and property of PVCA at molecular dynamic level.
Multimodal Analysis of the Visual Pathways in Friedreich's Ataxia Reveals Novel Biomarkers
Authors: Thomas‐Black Gilbert , Altmann Daniel R. , Crook Harry , Solanky Nita , Carrasco Ferran Prados , Battiston Marco , Grussu Francesco , Yiannakas Marios C. , Kanber Baris , Jolly Jasleen K. , Brett Jon , Downes Susan M. , Moran Marni , Chan Ping K. , Adewunmi Emmanuel , Gandini Wheeler‐Kingshott Claudia A.M. , Németh Andrea H. , Festenstein Richard , Bremner Fion , Giunti Paola 
Published: November 2022

AbstractBackgroundOptic neuropathy is a near ubiquitous feature of Friedreich's ataxia (FRDA). Previous studies have examined varying aspects of the anterior and posterior visual pathways but none so far have comprehensively evaluated the heterogeneity of degeneration across different areas of the retina, changes to the macula layers and combined these with volumetric MRI studies of the visual cortex and frataxin level.MethodsWe investigated 62 genetically confirmed FRDA patients using an integrated approach as part of an observational cohort study. We included measurement of frataxin protein levels, clinical evaluation of visual and neurological function, optical coherence tomography to determine retinal nerve fibre layer thickness and macular layer volume and volumetric brain MRI.ResultsWe demonstrate that frataxin level correlates with peripapillary retinal nerve fibre layer thickness and that retinal sectors differ in their degree of degeneration. We also shown that retinal nerve fibre layer is thinner in FRDA patients than controls and that this thinning is influenced by the AAO and GAA1. Furthermore we show that the ganglion cell and inner plexiform layers are affected in FRDA. Our MRI data indicate that there are borderline correlations between retinal layers and areas of the cortex involved in visual processing.ConclusionOur study demonstrates the uneven distribution of the axonopathy in the retinal nerve fibre layer and highlight the relative sparing of the papillomacular bundle and temporal sectors. We show that thinning of the retinal nerve fibre layer is associated with frataxin levels, supporting the use the two biomarkers in future clinical trials design. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
A novel design of recta‐tri substrate integrated waveguide antenna for ultra‐wideband applications
Authors: Balasundaram Gopi , Jeyapal Rajalakshmi , George Sugitha 
Published: November 2022

AbstractIn this paper low profile, low cost, and highly efficient antenna for ultra‐wideband (UWB) applications is presented. A novel shape of recta‐tri substrate integrated waveguide antenna is designed to achieve a wideband response and high efficiency. The proposed antenna is printed on FR4 substrate with a thickness of 1.6 mm. The overall antenna dimension is 30 × 35 mm2. The frequency of the antenna bandwidth ranges from 3.64 to 14.17 GHz with a peak gain of 7.7 dB. The field distribution of the proposed antenna is observed. The fabricated antenna results are tested and compared, which well agree with the simulated results. The proposed antenna is suitable for Wi‐Fi, ISM, and UWB applications.
A planar antenna array with wide frequency band and wide end‐fire beam
Authors: Xiao Ke , Ding Liang , Chai Shunlian 
Published: November 2022

AbstractA planar antenna array with wide frequency band and wide end‐fire radiation beam is proposed in this letter. The antenna element is composed of periodic structure, and its feeding position deviates from the center of symmetry, so end‐fire radiation is obtained. The measurement results show that the antenna array operates in the frequency range of 6.11−10.38 GHz with voltage standing wave ratio less than 2, and the corresponding impedance bandwidth is 51.7%. It exhibits a wide radiation beam of more than 80° at end‐fire direction and achieves realized gain of more than 8 dB in measured band.
A novel sensor system to detect cerebral hemorrhage in rabbits through MIPS
Authors: He Zhonghua , Chen Jingbo , Chen Mingsheng , Jin Gui , Zhuang Wei , Sun Jian , Zhao Shuanglin , Li Haocheng , Yang Wang , Zhou Lilong , Qin Mingxin 
Published: November 2022

AbstractBackgroundMagnetic‐induction phase shift (MIPS) was rarely used in vivo and clinically because of low sensitivity and nonquantitative detection. The conventional single excitation coil and single detection coil (single coil–coil) generates divergent excitation magnetic field, resulting in different sensitivity of different object positions.PurposeTo improve the sensitivity and linearity of MIPS and object volume to realize quantitative detection, a novel sensor system was proposed.MethodsThe novel sensor system adopted uniform rotating magnetic field replacing the divergent magnetic field for the first time integrated with primary field cancellation. The uniform rotating magnetic field was generated by a birdcage coil excited by two orthogonal current; the primary field cancellation was realized by a specially arranged solenoid receiver coil installed co‐axially with the birdcage coil detecting the z, not x and y‐component of the secondary magnetic field.ResultsThe saltwater simulation experiment showed that MIPS changed high linearity with the injection volume of all four different conductivity solutions. The experimental results of rabbit cerebral hemorrhage (CH) revealed that with injected blood volume increased to 3 ml, the MIPS linearly decreased to ‐1.916°, which was 5.5 times higher than that of the single coil–coil method.ConclusionCompared with the single coil–coil method, this novel detection system was more sensitive and linearly correlated for the detection of bleeding volume. It provided the probability of quantitative detection of the CH volume and a series of brain‐content diseases.
An efficient interactive segmentation framework for medical images without pre‐training
Authors: Sun Lei , Tian Zhiqiang , Chen Zhang , Luo Wenrui , Du Shaoyi 
Published: November 2022

AbstractBackground and PurposeAccurate and efficient medical image segmentation plays an important role in subsequent clinical applications such as diagnosis and surgical planning. This paper proposes an efficient interactive framework based on a graph convolutional network (GCN) for medical image segmentation.MethodsThe initial segmentation results showed that a set of boundary control points can be generated for further interactive segmentation. We presented an adaptive interactive manner that allows the user to click on the boundary for fast interaction or drag the erroneous predicted control points for accurate correction. Furthermore, we proposed an interactive segmentation network (referred to as IVIF‐GCN) to learn user experience in the interactive process by transforming interactive cues into annotations. In IVIF‐GCN, a module of information fusion of image features and vertex position features (IVIF) is proposed to learn the location relationship between the current vertex and the neighboring vertices. Finally, the locations of control points around the interaction point is predicted and updated automatically.ResultsThe proposed method achieves mean Dice of 96.6% and 91.3% on PROMISE12 and our in‐house nasopharyngeal carcinoma (NPC) test sets, respectively. The experimental results showed that the proposed method outperforms the state‐of‐the‐art segmentation methods.ConclusionsThe proposed interactive medical image segmentation method can efficiently improve segmentation results for clinical applications in the absence of training data. The GUI tool based on our method is available athttps://github.com/Tian‐lab/IGMedSeg.
The innovative 52gMn for positron emission tomography (PET) imaging: Production cross section modeling and dosimetric evaluation
Authors: Barbaro Francesca , Canton Luciano , Carante Mario Pietro , Colombi Alessandro , De Nardo Laura , Fontana Andrea , Meléndez‐Alafort Laura 
Published: November 2022

AbstractBackgroundManganese is a paramagnetic element suitable for magnetic resonance imaging (MRI) of neuronal function. However, high concentrations of Mn2 + can be neurotoxic. 52gMn may be a valid alternative as positron
emission tomography (PET) imaging agent, to obtain information similar to that delivered by MRI but using trace levels of Mn2 + , thus reducing its toxicity. Recently, the reaction V(α,x)52gMn has been proposed as a possible alternative to the standard Cr(p,x)52gMn one, but improvements in the modeling were needed to better compare the two production routes.PurposeThis work focuses on the development of precise simulations and models to compare the 52gMn production from both reactions in terms of amount of activity and radionuclidic purity (RNP), as well as in terms of dose increase (DI) due to the co‐produced radioactive contaminants, versus pure 52gMnCl2.MethodsThe nuclear code Talys has been employed to optimize the V(α,x)52gMn cross section by tuning the parameters of the microscopic level densities. Thick‐target yields have been calculated from the expression of the rates as energy convolution of cross sections and stopping powers, and finally integrating the time evolution of the relevant decay chains. Dosimetric assessments of [Mn]Cl2 have been accomplished with OLINDA software 2.2.0 using female and male adult phantoms and biodistribution data for 52gMnCl2 in normal mice. At the end, the yield of Mn radioisotopes estimated for the two production routes have been combined with the dosimetric results, to assess the DI at different times after the end of the irradiation.ResultsGood agreement was obtained between cross‐section calculations and measurements. The comparison of the two reaction channels suggests that V(α,x)52gMn leads to higher yield and higher purity, resulting in more favorable radiation dosimetry for patients.ConclusionsBoth V(α,x) and Cr(p,x) production routes provide clinically acceptable 52gMnCl2 for PET imaging. However, the V(α,x)52gMn reaction provides a DI systematically lower than the one obtainable with Cr(p,x)52gMn and a longer time window in which it can be used clinically (RNP ≥ 99%).
A contrast‐enhanced MRI‐based nomogram to identify lung metastasis in soft‐tissue sarcoma: A multi‐centre study
Authors: Hu Yue , Wang Hongbo , Yue Zhibin , Wang Xiaoyu , Wang Yan , Luo Yahong , Jiang Wenyan 
Published: November 2022

AbstractBackgroundLung metastasis (LM) status is critical for making treatment decisions in soft‐tissue sarcoma (STS) patients, yet magnetic resonance imaging (MRI)‐based prediction of LM in STSs has not been thoroughly investigated.PurposeThis study aimed to develop MRI‐based radiomics models for identifying LM in STSs.MethodsWe enrolled 122 STS patients from our hospital to form a primary cohort. Thirty‐two patients from another hospital were included as an external validation cohort. All patients underwent T1‐weighted contrast‐enhanced (T1‐CE) MRI scans before treatment. Radiomics features were extracted from T1‐CE MRI sequence and selected by least absolute shrinkage and selection operator (LASSO) to build the radiomics signature. Clinical factors were evaluated using the univariate and multivariate analyses. Multivariable logistic regression analysis was used to construct a clinical‐radiomics nomogram incorporating the radiomics signature with margin. Receiver operating characteristic (ROC), calibration and decision curve analysis (DCA) curves were plotted and area under the ROC curves (AUCs) were calculated to assess the predictive performance of nomogram, radiomics signature and margin.ResultsA total of five features was finally identified highly related to the LM status to develop the radiomics signature. The nomogram integrating the radiomics signature and margin achieved the best prediction performance in the training (AUCs, nomogram vs. radiomics signature vs. margin, 0.918 vs. 0.894 vs. 0.609), internal validation (AUCs, nomogram vs. radiomics signature vs. margin, 0.864 vs. 0.841 vs. 0.666) and external validation (AUCs, nomogram vs. radiomics signature vs. margin, 0.843 vs. 0.800 vs. 0.643) sets.ConclusionsThe developed nomogram was a promising tool to help make preoperative treatment strategies for STSs.
The clinical & economic burden of treatment‐resistant depression in the Gulf‐Cooperation Council: The Kingdom of Saudi Arabia, Kuwait and the United Arab Emirates
Authors: Akram Aly , Al‐Sabahy Medhat , Al‐Jedai Ahmed , Almudaiheem Hajer , Farghally Mohamed , Fallata Ebtihaj , Alibrahim Osama , Shoukry Tarek , Basu Sujata , Chalouhi Danielle , Elsharkawy Amr , Mohamed Omneya 
Published: November 2022

AbstractObjectiveThe current analysis assessed the economic and clinical burden of treatment‐Resistant Depression (TRD) imposed on the Kingdom of Saudi Arabia (KSA), Kuwait and United Arab Emirates (UAE) from the societal perspective.MethodsA Microsoft Excel® based Markov model was developed to estimate the overall burden of disease imposed by TRD across KSA, Kuwait and UAE. Data for the models' adaptation were retrieved from literature and validated by country‐specific key opinion leaders. The cycle length and time horizon used in the model were 4 weeks and 1 year, respectively.ResultsThe study results estimated that at the end of 1‐year time horizon, overall burden imposed by TRD was 3994, 982 and 670 million USD in KSA, Kuwait, and UAE, respectively. This can be attributed to the high cost incurred due to non‐responsive health state (ranging from 44% to 47%). The productivity loss was either the greatest or second greatest component of TRD's burden in the countries of interest (ranging from 32% to 43%).ConclusionsTRD represents a large clinical and economic burden on both individual patients and society. Hence, noval and innovative treatments are especially required for the management of TRD patients.
A 3D stack‐of‐spirals approach for rapid hyperpolarized 129Xe ventilation mapping in pediatric cystic fibrosis lung disease
Authors: Zanette Brandon , Munidasa Samal , Friedlander Yonni , Ratjen Felix , Santyr Giles 
Published: November 2022

PurposeTo demonstrate the feasibility of a rapid 3D stack‐of‐spirals (3D‐SoS) imaging acquisition for hyperpolarized 129Xe ventilation mapping in healthy pediatric participants and pediatric cystic fibrosis (CF) participants, in comparison to conventional Cartesian multislice (2D) gradient‐recalled echo (GRE) imaging.MethodsThe 2D‐GRE and 3D‐SoS acquisitions were performed in 13 pediatric participants (5 healthy, 8 CF) during separate breath‐holds. Images from both sequences were compared on the basis of ventilation defect percent (VDP) and other measures of image similarity. The nadir of transient oxygen saturation (SpO2) decline due to xenon breath‐holding was measured with pulse oximetry, and expressed as a percent change relative to baseline.Results129Xe ventilation images were acquired in a breath‐hold of 1.2–1.8 s with the 3D‐SoS sequence, compared to 6.2–8.8 s for 2D‐GRE. Mean ± SD VDP measures for 2D‐GRE and 3D‐SoS sequences were 5.02 ± 1.06% and 5.28 ± 1.08% in healthy participants, and 18.05 ± 8.26% and 18.75 ± 6.74% in CF participants, respectively. Across all participants, the intraclass correlation coefficient of VDP measures for both sequences was 0.98 (95% confidence interval: 0.94–0.99). The percent change in SpO2 was reduced to −2.1 ± 2.7% from −5.2 ± 3.5% with the shorter 3D‐SoS breath‐hold.ConclusionHyperpolarized 129Xe ventilation imaging with 3D‐SoS yielded images approximately five times faster than conventional 2D‐GRE, reducing SpO2 desaturation and improving tolerability of the xenon administration. Analysis of VDP and other measures of image similarity demonstrate excellent agreement between images obtained with both sequences. 3D‐SoS holds significant potential for reducing the acquisition time of hyperpolarized 129Xe MRI, and/or increasing spatial resolution while adhering to clinical breath‐hold constraints.
Development of a booster intervention for graded sensorimotor retraining (RESOLVE) in people with persistent low back pain: A nested, randomised, feasibility trial
Authors: O'Hagan Edel T. , Cashin Aidan G. , Rizzo Rodrigo R. N. , Leake Hayley B. , Zahara Pauline , Bagg Matthew K. , Wand Benedict M. , McAuley James H. 
Published: November 2022

AbstractIntroductionLow back pain contributes to an increasing global health burden exacerbated by unsustained improvements from current treatments. There is a need to develop, and test interventions to maintain initial improvements from low back pain treatments. One option is to implement a booster intervention. This study aimed to develop and test the feasibility of implementing a booster intervention delivered remotely to supplement the benefits from a complex intervention for chronic low back pain.MethodThis study was nested in the RESOLVE trial. The booster intervention was developed by an expert group, including a clinical psychologist, exercise physiologist and physiotherapists, and based on a motivational interviewing framework. We developed a conversational flow chart to support the clinician to guide participants towards achieving their pre‐specified personal goals and future low back pain self‐management. Participants with chronic low back pain who were aged over 18 years and fluent in English were recruited. The booster intervention was delivered in one session, remotely, by telephone. The intervention was considered feasible if: participants were able to be contacted or <3 contacts were necessary to arrange the booster session; there were sufficient willing participants (<15% of sample unwilling to participate); and participants and research clinicians reported a perceived benefit of >7/10.ResultsFifty participants with chronic non‐specific low back pain were recruited to test the feasibility of implementing the booster intervention. Less than three contact attempts were necessary to arrange the booster session, only one participant declined to participate. Participants perceived the session to be beneficial; on a 0 to 10 scale of perceived benefit, the average score recorded was 8.3 (SD 2.0). Clinicians also reported a moderate perceived benefit to the participant; the average score recorded by clinicians was 6.3 (SD 1.6).ConclusionWe developed a step by step, simple booster intervention that was perceived to be beneficial to participants with chronic low back pain. The booster can feasibly be delivered remotely following a complex intervention.
A longitudinal study of creatine kinase and creatinine levels in Duchenne muscular dystrophy
Authors: Zygmunt Alexander M. , Wong Brenda L. , Horn Paul S. , Lambert Joshua , Bange Jean E. , Rybalsky Irina , Chouteau Wendy , Tian Cuixia 
Published: November 2022

AbstractIntroduction/AimsManagement of Duchenne muscular dystrophy (DMD) has entered an era featuring novel treatments. Trackable noninvasive biomarkers could improve disease progression monitoring and drug effect detection. Our aim in this study was to measure changes in selected noninvasive biomarkers and assess their relationship to age and motor function.MethodsWe retrospectively studied 555 patients with DMD who had at least 12 months of treatment of glucocorticoids and were not enrolled in trials of potential disease‐modifying therapies. We extracted biomarker data of serum creatine kinase (CK), serum creatinine (Cr), urine Cr, and urine Cr/urine osmolality (osm), as well as functional data for age at loss of ambulation and Functional Motor Scale (FMS) values from patients’ clinical records. Data were analyzed using linear mixed‐model analyses.ResultsCK, serum Cr, urine Cr, and urine Cr/urine osm all decreased with declining motor function. CK consistently decreased and FMS score consistently worsened with age without clear inflection points. There was an increased odds ratio for LOA with lower values of CK, serum Cr, urine Cr, and urine Cr/urine osm, most notably for urine Cr.DiscussionAlthough individual biomarker values are challenging to directly apply clinically, our study has demonstrated that trends over time may complement functional measures in the assessment of individuals with DMD. Future studies could elucidate predictive utility of these biomarkers in assessing motor function changes in DMD.