bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting sexuality of elderly people and sexual dysfunctions
Authors: Fronc Kamila , Zielińska Patrycja , Kędziora-Kornatowska Kornelia 
Published: May 2022

Introduction: Sexuality of elderly people is often an omitted topic. There isn’t a compact definition of sexuality of seniors. The available data shows that there are many factors influencing sexual activity in later life. There are also specific changes which contribute sexual dysfunctions.
Purpose: The aim of present is to investigate what factors are related with decreased sexual activity of seniors, biological basis of sexual dysfunctions and how many elderly people it affects.
Materials and methods: There were analyzed publications from 2007 to 2022 from PubMed and Google Scholar using phrases: older adults, elderly people, sexuality of elderly people, factors influencing sexuality, sexual dysfunctions.
The state of knowledge: Almost half of people above 60 years old are sexually active. There are factors like low availability of partner, stereotypes, chronic diseases and treatments that contribute worse quality of sexual life. There are reports that communication between doctor and patient on the topic of sexuality is not sufficient, even more positive attitudes towards sexuality of seniors. Biological changes like lower hormone levels in women as well as in men contribute sexual dysfunctions. There are almost one in five women above 57 years old who feel pain during intercourse and there are about 43% of men above 65 with erectile problems. The awareness of sexual dysfunctions could make it easier to treat them.
Conclusions: It is essential to pay attention to psychological, social, cultural and attitudes of health professionals towards sexuality of elderly people to diagnose sexual dysfunctions. Understanding biological basis of sexual dysfunction can facilitate matching appropriate treatment. Education can improve seniors’s quality of life and sexual functions.
A literature review of the factors influencing the development of paternal symptoms of depression during the perinatal period
Authors: Kennedy Lauren , Ashmore Russell 
Published: May 2022

Background/Aims Depression during pregnancy and following the birth of a child is now also recognised as a paternal issue. However, the evidence has received little attention compared to maternal depression. The aim of this article was to systematically review the available evidence examining factors that influence the development of depressive symptoms in men during the perinatal period. Methods A systematic search of six electronic databases (CINAHL, MEDLINE, PsycINFO, Internurse, Intermid and Maternity and Infant Care) from the period 2010–19 was undertaken. A total of 20 studies were identified using the inclusion and exclusion criteria. Findings were synthesised using thematic analysis. Results A total of five synthesised risk factors were identified as pregnancy and infant, individual, social and relationship, psychological and demographic. Conclusions Expectant fathers are vulnerable to the development of depressive symptoms during the transition to parenthood. Mental health organisations should deliver services to support fathers during the perinatal period.
Staff and service users' experiences of the self-harm pathway on an acute inpatient ward
Authors: Parker Beth , Swift Elaine , Gkika Styliani 
Published: May 2022

Background/Aims A female acute inpatient mental health ward developed a care pathway to support women who self-harm during their admission. This service evaluation was the first to explore staff and patients' experiences of the care pathway using qualitative methods. Methods Semi-structured interviews were completed with eight staff members and five patients. Thematic analysis was used to analyse the interview data. Results Themes that developed from staff interviews were about effects on staff and staff support, enabling patients to manage self-harm autonomously and the ward environment. Themes developed from patient interviews included enabling engagement, putting skills into practice and least restrictive practice. Staff and patients viewed the pathway as effective in reducing self-harm incidents and levels of restriction on the ward. Conclusions The pathway was viewed positively by staff and patients, although improvements could be considered to increase its efficacy.
Revisiting the Functionally Generated Path Technique: Is this an Aid to Predictable Digital Occlusal Design? Part 1: Introduction and Background
Authors: Bereznicki Tom , Patel Rohit , Clark Megan 
Published: May 2022

Registering a pre-existing occlusal scheme is paramount to the long-term success of a fixed restoration(s) and a requirement when working conformatively, whether in analogue or digital format. Part 1 of this two-part series highlights those occlusal schemes that provide difficulties using established techniques in arriving at a predictable restoration requiring minimal occlusal adjustments chairside. Part 2 introduces the theory of the functionally generated path (FGP) technique, and two cases involving implant-retained restorations will be used to highlight the benefit of adopting this technique into the digital workflow in the provision of occlusally precise restorations. CPD/Clinical Relevance: This article provides an overview of difficult occlusal schemes and identifies those that would benefit from using the functionally generated path technique in the provision of occlusally correct restorations.
The non-operative management of primary osteoarthritis
Authors: Furey Joseph , Graziadei Vivien , Pilkington Isobel , Waterman Jacqueline 
Published: May 2022

Osteoarthritis is a syndrome characterised by joint pain, resulting in functional limitation and a decreased quality of life. This chronic condition is one of the major public health problems facing society today and is likely to become more prevalent. The expected increase is because of the primary causative factors, advancing age and obesity, becoming increasingly prevalent in society. The diagnosis of osteoarthritis can be made clinically when activity related joint pain is present, alongside morning joint stiffness that lasts for less than 30 minutes. However, a radiological diagnosis can also be made. This article examines the current management strategies, as outlined by the National Institute for Health and Care Excellence guidelines for osteoarthritis. Although numerous surgical options are available, this article focuses on the non-operative strategies currently used. The emphasis in this article is on general principles of treatment rather than treatment options for specific joints.
Terahertz photoconductive antenna based on antireflection dielectric metasurface with embedded plasmonic nanodisks: erratum
Authors: Jiang Xiao-Qiang , Fan Wen-Hui , Song Chao , Chen Xu , Wu Qi 
Published: May 2022

This erratum reports corrections in Figs. 5 and 8 of our previous paper
[Appl.
Opt. 60, 7921
(2021)APOPAI0003-693510.1364/AO.431678].
Oil temperature prediction of power transformers based on modified support vector regression machine
Authors: Xi Yu , Lin Dong , Yu Li , Chen Bo , Jiang Wenhui , Chen Guangqin 
Published: May 2022

Abstract
Power transformer is an important part of the entire power grid and the normal operation of the power transformer can ensure the normal operation of the entire power grid. The oil in the transformer plays a non-negligible role in the transformer. There are a lot of machine learning methods to predict oil temperature of power transformer. The work of this paper is to predict the oil temperature based on support vector regression machine (SVM) with three-phase power load, while particle swarm optimization (PSO) is employed for the model parameter optimization. As there are many influential factors for oil temperature prediction, confidence intervals are introduced to determine the prediction results. The experimental results show that the prediction accuracy reaches 90 with 85% confidence level. For the sample points falling outside the prediction interval, they can be regarded as the abnormal transformer status in time. The experimental results verified that the proposed oil temperature prediction method for power transformers based on modified SVM is effective and feasible.
Modal Metaphysics and the Existence of God
Authors: Sijuwade Joshua R. 
Published: May 2022

Abstract
In this article, I seek to assess the extent to which Theism, the claim that there is a God, can provide a true fundamental explanation for the existence of the infinite plurality of concrete and abstract possible worlds, posited by David K. Lewis and Alvin Plantinga. This assessment will be carried out within the (modified) explanatory framework of Richard Swinburne, which will lead to the conclusion that the existence of God provides a true fundamental explanation for these specific entities. And thus, given the truth of this type of explanation, we have another good abductive argument for God’s existence and grounds for affirming a weaker form of the principle of methodological naturalism in our metaphysical theorising.
Plasminogen Activator Inhibitor-1 Levels in Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Alsharoh Hasan , Ismaiel Abdulrahman , Leucuta Daniel-Corneliu , Popa Stefan-Lucian , Dumitrascu Dan L. 
Published: May 2022

Background and Aims: Several studies have investigated the role of multiple proteins in nonalcoholic fatty liver disease (NAFLD); one that has recently gained attention is plasminogen activator inhibitor-1 (PAI-1). However, studies evaluating PAI-1 levels in NAFLD demonstrated conflicting results. Our objective was to understand the role of PAI-1 in NAFLD more clearly by carrying out a systematic review and meta-analysis.
Methods: We gathered evidence by performing a systematic search on PubMed, EMBASE, and Cochrane Library, through using a predefined search string. The included studies diagnosed NAFLD through either liver biopsy, ultrasonography, computed tomography (CT), magnetic resonance spectroscopy, or using one of the latter methods with blood parameters. Studies had to fulfill predefined inclusion and exclusion criteria. To assess the quality of the studies included, we used the NHLBI quality assessment tools. The main summary outcome was the mean difference (MD) in serum PAI-1 levels reported as ng/mL
Results: 33 articles involving 10,840 subjects fulfilled our inclusion criteria and were systematically reviewed. 11 studies were included in our meta-analyses. We found a significant MD in PAI-1 levels in NAFLD patients vs. controls [17.147 (95%CI: 7.720–26.574)]. Moreover, subgroup analysis evaluating PAI-1 levels in biopsy- proven NAFLD vs. controls remained significant [24.086 (95%CI: 3.812–44.361)], as well as in CT-diagnosed NAFLD [15.523 (95%CI: 7.163–23.883)]. However, no significant MD in PAI-1 levels was found in ultrasound- diagnosed NAFLD patients vs. controls [10.394 (95%CI: -13.335–34.123)]. No significant MD in PAI-1 levels in NASH patients vs. controls was observed [26.835 (95%CI: -0.879–54.549)].
Conclusions: In summary, elevated serum PAI-1 levels are associated with adult NAFLD (biopsy-proven and CT-diagnosed). However, no significant difference was found in ultrasound-diagnosed NAFLD and NASH patients. Nonetheless, the included studies have methodological variance, dictating that the obtained results should be carefully interpreted.
Adjuvant Transarterial Chemoembolization for Patients with Intrahepatic Cholangiocarcinoma after Surgical Resection: A Systematic Review and Meta-analysis
Authors: Wang Lang , Wen Xiaoling , Zhuang Liping , Fang Kewei , Shen Jiang 
Published: May 2022

Aim: To investigate the efficacy of postoperative adjuvant transarterial chemoembolization (TACE) in patients with intrahepatic cholangiocarcinoma (ICC) after resection.
Methods: Studies were systematically searched until August 2021 in the following databases: MEDLINE, EMBASE, PUBMED, Web of Science, Cochrane Library, Science Direct, and Springer Link. Overall survival (OS) and recurrence-free survival (RFS) were considered as the main outcomes. Pooled hazard ratio (HR) with 95% confidence interval (95%CI) was reported as results for the survival data. Subgroup analysis was conducted on the outcomes stratified by early-stage ICC and intra-arterial chemotherapeutic regimen.
Results: Eleven studies with 2,757 patients were finally included in the study. The pooled HR of OS was 0.68 (95%CI: 0.50-0.87, I 2 =83.7%). The pooled HR of RFS was 1.00 (95%CI: 0.69-1.31, I 2 =88%). Receipt of postoperative adjuvant TACE improved the OS in the early-stage ICC subgroup (HR=0.68, 95%CI: 0.50-0.86, I 2 =54%). Addition of carboplatin could slightly improve the OS (HR=0.6, 95%CI: 0.35-0.85, I 2 =48%). But receipt of postoperative adjuvant TACE (HR=1.06, 95%CI: 0.83-1.29, I 2 =41.2%) or use of carboplatin (HR=1.30, 95%CI: 0.93-1.67, I 2 =0%) caused no significant improvement in the RFS in the early-stage ICC subgroup.
Conclusions: Postoperative adjuvant TACE could improve the OS in ICC patients after hepatectomy but could not prevent late recurrence. Survival benefit was also found in early-stage ICC patients undergoing postoperative adjuvant TACE after hepatectomy. Addition or non-addition of carboplatin in chemoembolization showed a similar OS outcome.
Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and their Role in the Poor Histological Outcome of the Stomach: A Single-centre, Retrospective Cross-sectional Study
Authors: Zádori Noémi , Németh Dávid , Szakó Lajos , Váncsa Szilárd , Vörhendi Nóra , Szakács Zsolt , Frim Levente , Hegyi Péter , Czimmer Jozsef 
Published: May 2022

Background and Aims: The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal metaplasia (IM) and eventually of gastric cancer is well documented. We aimed to explore the possible aetiological factors of CG, determine the prevalence of systemic autoimmune disorders in patients with CG of unknown aetiology, and clarify the role of autoantibodies in the development of precancerous lesions in the stomach.
Methods: This is a retrospective, cross-sectional study, conducted from January 2016 to January 2020, including data from 175 patients with CG. Exclusion criteria were: (1) acute gastritis; (2) reactive gastropathy; (3) gastric cancer; (4) subjects without any serology testing results; and (5) Helicobacter pylori positivity. The primary endpoint was a composite endpoint involving gastric atrophy and IM.
Results: Fifty-five per cent of patients with CG had autoantibodies. Systemic lupus erythematosus (SLE)-related antibodies were positive in most of the cases, including antinuclear antibody (ANA) positivity, which was found in 19.13% of the patients. Autoimmune positivity was shown to be associated with precancerous lesions in the stomach (p<0.001): IM, atrophy and IM with atrophy. Anti-parietal cell antibody positivity seems to be a significant risk factor for IM and IM with atrophy. Autoimmune thyroiditis-related antibodies and ANA positivity by itself were only associated with atrophy; SLE-related antibodies and inflammatory bowel diseases related antibodies (ASCA and ANCA) correlated either with IM or with atrophy. No significant relation was found between any other investigated autoimmune disease-related antibodies and precancerous lesions.
Conclusions: Autoimmune positivity often underlies gastritis of unknown aetiology and predisposes to precancerous lesions in the stomach. These antibodies can serve as non-invasive markers for the of optimal timing of an endoscopic follow-up strategy. Furthermore, CG can be an early symptom of a systemic autoimmune disorder.
Computed Tomography for the Diagnosis of Intraperitoneal Infected Fluid Collections after Surgery for Gastric Cancer. Role of Texture Analysis
Authors: Puia Vlad Radu , Puia Aida , Fetti Alin Cornel , Stefan Paul Andrei , Valean Dan , Herdean Andrei , Rusu Ioana , Vasile Tudor , Lebovici Andrei , Al-Hajjar Nadim 
Published: May 2022

Background and Aims: Several computed tomographic (CT) imaging features have been proposed to describe the infection of postoperative abdominal fluid collections; however, these features are vague, and there is a significant overlap between infected and non-infected collections. We assessed the role of textural parameters as additional diagnostic tools for distinguishing between infected and non-infected peritoneal collections in patients operated for gastric cancer.
Methods: From 527 patients operated for gastric cancer, we retrospectively selected 82 cases with intraperitoneal collections who underwent CT exams. The fluid component was analyzed through a novel method (texture analysis); different patterns of pixel intensity and distribution were extracted and processed through a dedicated software (MaZda). A univariate analysis comparing the parameters of texture analysis between the two groups was performed. Afterwards, a multivariate analysis was performed for the univariate statistically significant parameters.
Results: The study included 82 patients with bacteriologically verified infected (n=40) and noninfected (n=42) intraperitoneal effusions. The univariate analysis evidenced statistically significant differences between all the parameters involved. The multivariate analysis highlighted 10 parameters as being statistically significant, adjusted to Bonferroni correction.
Conclusions: Our evidence supports the fact that textural analysis can be used as a complementary diagnostic tool for the detection of infected fluid collections after gastric cancer surgery. Further studies are required to validate the accuracy of this method.
Helicobacter Pylori Colonization Density is an Important Risk Factor for Eradication Therapy
Authors: Demirci Hakan , Ozturk Kadir , Tanoglu Alpaslan , Kilciler Ayse Guldem , Gunal Armagan , Gulsen Mustafa , Uygun Ahmet 
Published: May 2022

Background and Aims: Despite the known risk factors, it is not clear why the same treatment protocol for Helicobacter pylori infection (H. pylori) doesnot show a similar effect in patients with common risk factors. We hypothesized that as the severity of H. pylori - induced gastric mucosa inflammation and density increase, the rate of successful treatment decreases. This study aimed to explore the existence of a possible association between gastric H. pylori colonization density and the efficacy of bismuth-containing quadruple eradication therapy.
Methods: A total of 330 patients with H. pylori positive gastritis were initially included; the diagnosis was based on the histopathological examination. H. pylori colonization density was graded according to the Sydney classification: mild (n=101), moderate (104) and severe (98). H. pylori eradication was determined via the 13C-Urea breath test performed eight weeks after therapy.
Results: There was no significant difference in terms of the distributions of age, gender, alcohol consumption, and smoking status among the groups (p>0.05). The successful eradication rates of H. pylori were 87.1%, 78.8%, and 75.5%, respectively, for the mild, moderate, and severe H. pylori colonization groups by per-protocol analysis (p=0.038). The eradication rates of H. pylori were 81.5%, 73.2%, and 67.3% respectively, for the mild, moderate, and severe H. pylori colonization groups by intention-to-treat analysis (p=0.017).
Conclusions: Helicobacter pylori colonization severity might predict the usefulness of eradication therapy in pre-treatment assessment. We recommend the use of more effective therapy regimens for H. pylori eradication in patients with severe densities.
Optimising confocal Raman microscopy for spectral mapping of cement-based materials
Authors: Zhang K. , Yio M. H. N. , Wong H. S. , Buenfeld N. R. 
Published: May 2022

AbstractRaman spectroscopy combined with confocal imaging, i.e. confocal Raman microscopy (CRM) is a relatively new technique with huge potential for high-resolution chemical mapping of phase composition and spatial distribution in cement-based materials. However, the effects of sample preparation and various operating parameters on mapping quality has not been systematically studied. This paper optimises CRM for spectral mapping of carbonated and non-carbonated cement-based materials. The effects of sample preparation and scanning parameters on the detection of four main phases (calcite, portlandite, ettringite and unreacted cement) were investigated. Results show that although freshly cut cementitious samples can be analysed as-is, the Raman signals improve with short gentle drying and surface grinding/polishing prior to analysis. Increasing laser power, exposure time and scan accumulation, and short laser wavelength yields higher signal-to-noise (SNR) ratio in the obtained spectrum. The use of a 4.15 mW laser power, 2 s exposure time and scan accumulation of 2 with 532 nm laser represents a good operating condition for Raman analysis of cement-based materials. This produces SNR > 10 for all investigated phases at short testing time and low risk of laser-induced damage. Microcracking caused by localised heating during closely-spaced mapping can be limited by impregnating the sample with epoxy to protect the microstructure. We show for the first time that CRM can be used to quantify the volume fraction of calcium carbonate and portlandite at high resolution when combined with SEM. The advantages and limitations of CRM for mapping cement-based materials are discussed.
The effect of sarcopenia on erlotinib therapy in patients with metastatic lung adenocarcinoma
Authors: Topcu Atakan , Ozturk Akin , Yurtsever Ismail , Besiroglu Mehmet , Yasin Ayse Irem , Turk Haci Mehmet , Seker Mesut 
Published: May 2022

Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may predict a poor prognosis. We aimed to evaluate the impact of sarcopenia on erlotinib therapy and prognosis in patients with EGFR-mutated (exon 19 or 21 L858R) metastatic lung adenocarcinoma. Sarcopenia was defined as skeletal muscle index ≤39 cm2/m2 for women and ≤55 cm2/m2 for men. The patient characteristics, inflammation parameters, clinical and survival outcomes of the erlotinib therapy were examined according to sarcopenia status. We also analyzed the erlotinib treatment-related toxicity. Seventy-two patients were included in our retrospective study, and the mean age of the patients was 63.7 years. A total of 39 (54.2%) patients were diagnosed with sarcopenia. Patients with sarcopenia had a poor prognosis and had a shorter median progression-free survival (PFS) than patients without sarcopenia (10.5 months vs. 21.8 months, p=0.002). Sarcopenia (HR 2.08) and C-reactive protein > 6.5 mg/L (HR 2.57) were determined as independent poor prognostic factors for PFS of erlotinib therapy. Treatment-related toxicity occurred in 34.7% of patients treated with erlotinib, and sarcopenia did not significantly affect treatment-related toxicity. We also found that sarcopenia significantly affected the response to erlotinib. The expected survival outcomes may be low when erlotinib therapy is used in patients with sarcopenia and metastatic lung adenocarcinoma. This study showed that survival and clinical outcomes could be better predicted by detecting sarcopenia in patients with lung cancer using erlotinib.