bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN APLIKASI ADMINISTRASI DESA PADA DESA MUKTI KARYA MESUJI
Authors: Styawati Styawati , Samsugi Selamet , Rahmanto Yuri , Surahman Ade , Andraini Lili , Ismail Izudin 
Published: March 2022

Kantor desa merupakan tempat atau pusat pelayanan di desa. Pelayanan dari sebuah kantor desa dapat mencerminkan pribadi dari setiap staf pelayanan di sebuah kantor desa. Pelayanan yang diberikan kepada masyarakat desa dituntut harus cepat dan akurat. Salah satu desa yang dituntut untuk memiliki kecepatan dalam pelayanan yaitu Desa Mukti Karya Mesuji. Pelayanan yang diberikan salah satunya adalah pengajuan surat menyurat. Permasalahan yang dialami oleh Desa Mukti Karya yaitu seluruh proses pengurusan administrasi masih dilakukan secara konvensional sehingga tidak efisien dalam hal waktu. Sistem konvensional tersebut juga dikhawatirkan membuat data yang tercatat lebih mudah rusak dan hilang. Dalam penerbitan surat yang diajukan, masyarakat juga harus datang ke kantor desa dan antri mengisi semua berkas yang diperlukan untuk pembuatan penerbitan surat. Berdasarkan permasalahan yang telah dipaparkan, tim PKM Universitas Teknokrat Indonesia membangun Aplikasi Administrasi Desa Mukti Karya. Berdasarkan hasil kuesioner yang diisi oleh staf desa, terdapat peningkatan dalam hal pelayanan desa. Hal itu dibuktikan dengan hasil kuesioner sebelum aplikasi diimplementasikan, tingkat kemudahan pelayanan administrasi desa rata-rata sebesar 46.8%. Sedangkan setelah aplikasi diterapkan tingkat kemudahan administrasi desa sebesar 94.4%. Peningkatan yang terjadi pada pelayanan administrasi surat pengajuan di desa Mukti Karya sebesar 47.6%.
Lifestyles Under Lockdown: A Scoping Review of International Studies on Type 2 Diabetes Self-Management Behaviors During COVID-19
Authors: Cummings Caroline , Seng Kagnica , Tweet Ryan , Wagner Julie 
Published: March 2022

BackgroundThe effect of the COVID-19 pandemic on diabetes self-management behaviors is unclear.ObjectivesThis paper is a scoping review of studies examining health behaviors among people with type 2 diabetes during the COVID-19 pandemic.Eligibility CriteriaWe searched articles available in English using the Search terms “COVID” and “diabetes”, and, separately, each of the following terms: “lifestyle”, “health behavior”, “self-care”, “self-management”, “adherence”, “compliance”, “eating”, “diet”, “physical activity”, “exercise”, “sleep”, “self-monitoring of blood glucose”, or “continuous glucose monitoring”.Sources of EvidenceWe searched PubMed, PsychInfo, and Google Scholar databases from December 2019 through August 2021.Charting MethodsData were extracted by 4 calibrated reviewers and study elements were charted.ResultsThe search identified 1,710 articles. After screening for relevance and eligibility, 24 articles were included in this review. Findings show the strongest evidence for reduced physical activity and stable glucose monitoring and substance use. There was equivocal evidence for deleterious changes in sleep, diet, and medication intake. With one minor exception, there was no evidence for favorable changes in health behaviors. Limitations of the literature include small samples, predominantly cross-sectional study designs, reliance on retrospective self-reports, sampling through social media, and few standardized measures.ConclusionsEarly studies of health behaviors among people with type 2 diabetes during the COVID-19 pandemic suggest a need for novel interventions to support diabetes self-management, especially targeting physical activity. Future studies should go beyond documenting changes in health behaviors and examine predictors of change over time.
Characterization of the Different Subtypes of Immune Cell Infiltration to Aid Immunotherapy
Authors: Li Zhenqing , Mao Kai , Ding Bo , Xue Qun 
Published: March 2022

Background?PD-1 ablation or PD-L1 specific monoclonal antibody against PD-1 can recruit the accumulation of functional T cells, leading to tumor rejection in the microenvironment and significantly improving the prognosis of various cancers. Despite these unprecedented clinical successes, intervention remission rates remain low after treatment, rarely exceeding 40%. The observation of PD-1/L1 blocking in patients is undoubtedly multifactorial, but the infiltrating degree of CD8+T cell may be an important factor for immunotherapeutic resistance.Methods:We proposed two computational algorithms to reveal the immune cell infiltration (ICI) landscape of 1646 lung adenocarcinoma patients. Three immune cell infiltration patterns were defined and the relative ICI scoring depended on principal-component analysis.Results:A high ICI score was associated with the increased tumor mutation burden and cell proliferation-related signaling pathways. Different cellular signaling pathways were observed in low ICI score subtypes, indicating active cell proliferation, and may be associated with poor prognosis.Conclusion:Our research identified that the ICI scores worked as an effective immunotherapy index, which may provide promising therapeutic strategies on immune therapeutics for lung adenocarcinoma.
Reactivation of the Neurogenic Niche in the Adult Zebrafish Statoacoustic Ganglion Following a Mechanical Lesion
Authors: Schwarzer Simone , Rekhade Devavrat Ravindra , Machate Anja , Spieß Sandra , Geffarth Michaela , Ezhkova Diana , Hans Stefan 
Published: March 2022

Sensorineural hearing loss is caused by the loss of sensory hair cells and/or their innervating neurons within the inner ear and affects millions of people worldwide. In mammals, including humans, the underlying cell types are only produced during fetal stages making loss of these cells and the resulting consequences irreversible. In contrast, zebrafish produce sensory hair cells throughout life and additionally possess the remarkable capacity to regenerate them upon lesion. Recently, we showed that also inner ear neurogenesis continues to take place in the zebrafish statoacoustic ganglion (SAG) well into adulthood. The neurogenic niche displays presumptive stem cells, proliferating Neurod-positive progenitors and a high level of neurogenesis at juvenile stages. It turns dormant at adult stages with only a few proliferating presumptive stem cells, no proliferating Neurod-positive progenitors, and very low levels of newborn neurons. Whether the neurogenic niche can be reactivated and whether SAG neurons can regenerate upon damage is unknown. To study the regenerative capacity of the SAG, we established a lesion paradigm using injections into the otic capsule of the right ear. Upon lesion, the number of apoptotic cells increased, and immune cells infiltrated the SAG of the lesioned side. Importantly, the Neurod-positive progenitor cells re-entered the cell cycle displaying a peak in proliferation at 8 days post lesion before they returned to homeostatic levels at 57 days post lesion. In parallel to reactive proliferation, we observed increased neurogenesis from the Neurod-positive progenitor pool. Reactive neurogenesis started at around 4 days post lesion peaking at 8 days post lesion before the neurogenesis rate decreased again to low homeostatic levels at 57 days post lesion. Additionally, administration of the thymidine analog BrdU and, thereby, labeling proliferating cells and their progeny revealed the generation of new sensory neurons within 19 days post lesion. Taken together, we show that the neurogenic niche of the adult zebrafish SAG can indeed be reactivated to re-enter the cell cycle and to increase neurogenesis upon lesion. Studying the underlying genes and pathways in zebrafish will allow comparative studies with mammalian species and might provide valuable insights into developing cures for auditory and vestibular neuropathies.
Effect of Gallium as an Additive Over Corresponding Ni–Mo/γ-Al2O3 Catalysts on the Hydrodesulfurization Performance of 4,6-DMDBT
Authors: Huang Meng , Huang Wenbin , Li Anqi , Yang Han , Jia Yijing , Yu Zhiqing , Xu Zhusong , Wang Xiaohan , Zhou Yasong , Wei Qiang 
Published: March 2022

Experiments were carried out to research the different contents of Ga2O3 modification effects on the hydrodesulfurization (HDS) performance of 4,6-dimethyldibenzothiophene (4,6-DMDBT) catalyzed by the stepwise impregnation method. Characterization techniques such as XRD, BET, HRTEM, NH3-TPD, and Py-FTIR were performed to determine the effects of each modification of the catalyst by Ga on the properties of the prepared supports and catalysts. The catalytic effect of gallium is reflected in the fact that the empty d-orbitals of Ga elements participate in the formation of molecular orbitals in the active center and change their orbital properties, thus generating a direct desulfurization active phase suitable for complex sulfides for endpoint adsorption. The characterization results indicated that the introduction of Ga2O3 with appropriate content (2 wt.%) promoted Ni and Mo species to disperse uniformly and doping of more Ni atoms into the MoS2 crystals, which also increased the average stacking number and the length of MoS2. As a result, more NiMoS active phases were favored to form in the system. The specific surface area and the amounts of acid sites were increased, facilitating the adsorption of reactant molecules and the HDS reactions. The HDS results also suggested the effects of Ga modification play a very important role in the catalytic performance of the corresponding catalysts. The catalyst Ga–Ni–Mo/Al2O3 exhibited the highest conversion rate towards 4,6-DMDBT HDS when the amount of Ga2O3 loading was 2 wt.% with an LHSV of 2.5 h−1 at 290°C and Ga modification also can effectively improve the direct desulfurization (DDS) route selectivity in varying degrees.
Continuum of Care: Positioning of the Virtual Hospital
Authors: van der Lande Anne Catherine M. H. , Treskes Roderick W. , Beeres Saskia L. M. A. , Schalij Martin J. 
Published: March 2022

IntroductionPatients with multiple chronic diseases suffer from reduced life expectancy. Care for these patients is often divided over multiple healthcare professionals. eHealth might help to integrate care for these patients and create a continuum. It is the primary purpose of this paper to describe an intervention that integrates first, second, and third line care in patients with multiple chronic conditions using remote monitoring, remote therapy and data automatization, all integrated in a virtual care center (VCC).MethodsPatients diagnosed with three or more chronic conditions are included and given smartphone compatible devices for remote monitoring and a tablet for video consultations. Patients will be followed-up by the VCC, consisting of nurses who will coordinate care, supervised by general practitioners and medical specialists. Data is reviewed on a daily basis and patients are contacted on a weekly basis. Review of data is automated by computer algorithms. Patients are contacted in case of outcome abnormalities in the data. Patients can contact the VCC at any time. Follow-up of the study is 1 year.ResultsThe primary outcome of this study is the median number of nights admitted to the hospital per patient compared to the hospitalization data 12 months before enrolment. Secondary outcomes include all-cause mortality, event free survival, quality of life and satisfaction with technology and care.ConclusionThis study presents the concept of a VCC that integrates first, second, and third line care into a virtual ward using remote monitoring and video consultation.
Negative Risk Markers for Cardiovascular Risk Evaluation in Chinese Adults
Authors: Bie Lizhan , Niu Jingya , Wu Shujing , Zheng Ruizhi , Xu Min , Lu Jieli , Wang Tiange , Zhao Zhiyun , Wang Shuangyuan , Lin Hong , Dai Meng , Zhang Di , Chen Yuhong , Bi Yufang , Wang Weiqing , Ning Guang , Li Mian , Xu Yu 
Published: March 2022

BackgroundThe atherosclerotic cardiovascular disease (ASCVD) risk predicted by traditional risk factors is used to guide preventive treatment. We aimed to investigate whether preferable levels of non-traditional emerging risk factors (i.e., negative risk markers) could downgrade the predicted ASCVD risk beyond traditional risk factors.MethodsA total of 7,568 Chinese adults aged ≥ 40 years were followed up during 2010–2015. Negative risk markers including non-traditional lipids, urinary albumin-to-creatinine ratio, electrocardiogram (ECG), and measurements of atherosclerosis were evaluated using diagnostic likelihood ratio (DLR) and continuous net reclassification index (NRI) for their ability to downshift predicted CVD risk in the overall study population and in participants with intermediate (traditional risk factor predicted ASCVD risk 7.5% to 19.9%) or high risk (≥20%).ResultsDuring a median follow-up of 4.5 years, 416 participants developed CVD events including non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death. Among negative risk markers examined, lipoprotein(a) ≤ 10th percentile (5 mg/dL), normal ECG, and carotid intima-media thickness (CIMT) ≤ 25th percentile (0.5 mm) provided moderate CVD risk reclassification and downward changes in pre- to post-test risk on top of the traditional CVD risk factors, especially in high-risk participants. The DLRs were 0.41, 0.75, and 0.41, and the NRIs were 18, 22, and 14% for lipoprotein(a), ECG, and CIMT, respectively in high-risk participants.ConclusionsLipoprotein(a) ≤ 5 mg/dL, normal ECG, and CIMT ≤ 0.5 mm might be used as negative non-traditional risk markers to correctly downgrade predicted ASCVD risk in Chinese adults.
A Multicenter Randomized Trial Assessing ZENFlow Carrier-Free Drug-Coated Balloon for the Treatment of Femoropopliteal Artery Lesions
Authors: Ni Leng , Ye Wei , Zhang Lan , Jin Xing , Shu Chang , Jiang Jin-song , Yang Mu , Wu Dan-ming , Li Ming , Yu Guan-feng , Yang Jun , Huang Jian-hua , Wang Xiao-bai , Li Xiao-qiang , Jiang Wei-liang , Wu Zhi-qun , Liu Chang-wei 
Published: March 2022

Backgrounds and ObjectivesDrug-coated balloons (DCBs) have shown promising benefits in improving the outcomes for patients with peripheral artery disease. Several randomized clinical trials have reported that paclitaxel-coated balloon significantly reduce the rates of restenosis and the need for reintervention in comparison with regular balloon angioplasty. Due to the differences in excipients, paclitaxel dose, and coating techniques, variable clinical outcomes have been observed with different DCBs. In this study, we aimed to evaluate the safety and efficacy of a novel ZENFlow carrier-free DCB in the treatment of femoropopliteal artery occlusive disease.MethodsIn this randomized controlled trial conducted at 15 sites, 192 patients with Rutherford class 3–5 were randomly assigned into two groups: drug-coated balloon group and percutaneous transluminal angioplasty group. The primary endpoint was a late lumen loss at 6 months based on blinded angiographic core laboratory evaluations, and the secondary endpoints included primary patency rate, binary restenosis, clinically driven target lesion revascularization, ankle-brachial index, Rutherford class change, and major adverse events.ResultsIn this multicenter trial, 93 patients received DCB angioplasty, whereas 99 patients underwent regular balloon angioplasty. The late lumen loss at 6-month follow-up was 0.50 ± 0.82 and 1.69 ± 0.87 mm in the drug-coated balloon and percutaneous transluminal angioplasty groups, respectively (p &lt; 0.001). During the 12-month follow-up period, the drug-coated balloon group showed a significantly higher primary patency rate (54 vs. 31.3%, p = 0.009) and markedly lower rates of target vessel restenosis (22.1 vs. 64.3%, p &lt; 0.001) and clinically driven target lesion revascularization rate (5.4 vs. 19.2%, p = 0.006) than the percutaneous transluminal angioplasty group. Compared with the percutaneous transluminal angioplasty group, the drug-coated balloon group had significant improvements in the ankle-brachial index and Rutherford class. The all-cause mortality rate was comparable, and no device-related deaths occurred in either groups.ConclusionsBalloon angioplasty using a ZENFlow carrier-free drug-coated balloon is a safe and effective treatment method for femoropopliteal artery lesions. This novel drug-coated balloon catheter achieved satisfactory early and 1-year outcomes in this trial.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier: NCT03844724.
Impacts of Permafrost Degradation on Hydrology and Vegetation in the Source Area of the Yellow River on Northeastern Qinghai-Tibet Plateau, Southwest China
Authors: Jin Xiaoying , Jin Huijun , Luo Dongliang , Sheng Yu , Wu Qingbai , Wu Jichun , Wang Wenhui , Huang Shuai , Li Xiaoying , Liang Sihai , Wang Qingfeng , He Ruixia , Serban Raul D. , Ma Qiang , Gao Shuhui , Li Yan 
Published: March 2022

Under a persistent warming climate and increasing human activities, permafrost in the Source Area of the Yellow River (SAYR) has been degrading regionally, resulting in many eco-environmental problems. This paper reviews the changes in air temperature and precipitation over the past 60 years and presents the distribution and degradation of alpine permafrost in the SAYR. The review is focused on the permafrost degradation–induced changes in hydrology, wetlands, thermokarst lakes, ponds, and vegetation. Mean annual air temperatures have been rising at an average rate of 0.4°C/10a over the past 60 years, while precipitation has increased only slightly (16 mm/10a). Borehole temperature monitoring at the depth of 15 m shows the permafrost warming rates of 0.01–0.21°C/10a in the Headwater Aera of the Yellow River. As a result of permafrost thaw, the amount of surface waters has declined while groundwater storage has increased. Due to permafrost degradation, the supra-permafrost water table lowers gradually, resulting in a reduction in areal extents of wetlands and lakes in the SAYR. We further renamed the concept of the burial depth of the ecologically-safe supra-permafrost water table, the minimum depth of the groundwater table for sustaining the normal growth of alpine grassland vegetation, for the SAYR to describe the relationship between the lowering permafrost table and succeeding alpine vegetation. Furthermore, we recommended more studies focusing on snow cover and carbon stock and emissions related to permafrost degradation under a warming climate. We also advised to timely establish the long-term monitoring networks for the rapidly changing mountain cryosphere, alpine ecology, alpine hydrology, eco-hydrology, cryo-hydrogeology, and carbon fluxes. Moreover, process-based models should be developed and improved to better simulate and predict the responses of alpine ecosystem changes to the interacting cryospheric and other environmental variables and their ecological and ecohydrological impacts in the SAYR and downstream Yellow River basins. This study can help better manage the ecological and hydrological environments in the Upper Yellow River that are sensitive to changes in the alpine climate and cryosphere.
Early Oligocene—Late Miocene Wildfire History in the Northern Tibetan Plateau and Links to Temperature-Driven Precipitation Changes
Authors: Miao Yunfa , Chang Hong , Li Lin , Cheng Feng , Garzione Carmala , Yang Yongheng 
Published: March 2022

Late Cenozoic wildfire evolution in Inner Asia has been attributed to both ice-volume modulating precipitation changes and surface uplift of the Tibetan Plateau. Whether this is the case or not requires additional research and wildfire records from older periods. In this study, 251 microcharcoal samples from the Huatugou section in the western Qaidam Basin are used to reconstruct the early Oligocene-middle Miocene wildfire history of the northern Tibetan Plateau. The results show that wildfires remained relatively frequent before ∼26 Ma, then reduced gradually until ∼14 Ma, and finally increased slightly but still at low level between 14 and 12 Ma. The wildfire variations can be correlated to the steppe-based dryness changes, and both of which are coincident with global temperature changes. We infer that mean annual temperature might have played a dominant role in controlling wildfire frequencies in the northern Tibetan Plateau through modulating atmospheric moisture content. This conclusion is in line with previous studies including microcharcoal-based wildfire records of 18–5 Ma successions from the Qaidam Basin as well as soot-based wildfire records from Quaternary glacial–interglacial cycles of the Chinese Loess Plateau.
Determinants of People’s Secondary Hazards Risk Perception: A Case Study in Wenchuan Earthquake Disaster Areas of China
Authors: Huang Huan , Wang Rui , Xiao Yi , Li Yuan , Zhang Qiu-Feng , Xiang Xin 
Published: March 2022

Few studies have examined people’s subjective perceptions of risk after secondary disasters. This study selected 12 towns in the areas where secondary geological hazards (SGH) occurred after the Wenchuan earthquake as the survey research areas and obtained a total of 957 valid samples to assess the risk perceptions of residents and the factors influencing them 10 years after the disaster. Using four indicators (possibility, awareness, apprehension, and impact) to construct the Resident Risk Perception Index (RRPI), the results show that residents in the affected areas have high, moderate, and low-risk perceptions of SGH at 27.59, 48.38, and 24.03% respectively. The study found that people who suffered in the past from geological disasters had a higher risk perception. Perceptions of secondary geological hazard risk varied significantly with age, education, marital status, and experience. It was also found that residents in the 30–40 age group have the highest risk perception, young people in the 20–30 age group have the highest risk awareness, and older people over 60 are more fearful of SGH. The study recommends awareness campaigns and adequate disaster preparedness exercises to improve the risk perception of local people, especially to foster ownership of learning about disasters among residents.
Relationship Between Acylcarnitine and the Risk of Retinopathy in Type 2 Diabetes Mellitus
Authors: Wang Wan-Ying , Liu Xu , Gao Xiao-Qian , Li Xin , Fang Zhong-Ze 
Published: March 2022

ObjectiveDiabetic retinopathy is a common complication of type 2 diabetes mellitus (T2DM). Due to the limited effectiveness of current prevention and treatment methods, new biomarkers are urgently needed for the prevention and diagnosis of DR. This study aimed to explore the relationships between plasma acylcarnitine with DR in T2DM.MethodsFrom May 2015 to August 2016, data of 1032 T2DM patients were extracted from tertiary hospitals. Potential non-linear associations were tested by binary logistic regression models, and ORs and 95% CIs of the research variables were obtained. Correlation heat map was used to analyze the correlation between variables. The change of predictive ability was judged by the area under the receiver operating characteristic curve.ResultsOf the 1032 patients with T2DM, 162 suffered from DR. After adjusting for several confounding variables, C2 (OR:0.55, 95%CI:0.39-0.76), C14DC (OR:0.64, 95%CI:0.49-0.84), C16 (OR:0.64, 95%CI:0.49-0.84), C18:1OH (OR:0.51, 95%CI:0.36-0.71) and C18:1 (OR:0.60, 95%CI:0.44-0.83) were negatively correlated with DR. The area under the curve increased from 0.794 (95% CI 0.745 to 0.842) to 0.840 (95% CI 0.797 to 0.833) when C2, C14DC, C18:1OH and C18:1 added to the traditional risk factor model.ConclusionThere was a negative correlation between C2, C14DC, C16, C18:1OH, and C18:1 and the risk of retinopathy in patients with T2DM. C2, C14DC, C18:1OH, and C18:1 may be new predictors and diagnostic markers of DR.