bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Expanded Crowned Macrocycles Containing Two Pyrrolo[1,2‐a]indole Units
Authors: Ojha Belarani , Laxman Kandala , Rawat Nisha , Ravikanth Mangalampalli 
Published: April 2022

AbstractExpanded crowned macrocycles containing two pyrrolo[1,2‐a]indole moieties in their macrocyclic framework have been synthesized by condensing a 1,4‐bis(2‐thienyl) benzene‐based diol with three different crown based tripyrranes under acid‐catalyzed conditions. HRMS and NMR studies were used to deduce the molecular structures of fused expanded crowned macrocycles. The studies indicated the occurrence of two intramolecular fusions between two core pyrrolic nitrogens with carbon atoms of two phenylene groups to generate two pyrrolo[1,2‐a]indole moieties as a part of expanded porphyrin framework. DFT studies indicated that the macrocycles are highly nonplanar and adopt a trapezoidal structure. The absorption spectral studies showed that the macrocycles exhibit three bands in 350–520 nm region and electrochemical studies indicated the electron‐rich nature of the macrocycles. Furthermore, the expanded crowned macrocycles form stable cation radicals upon treatment with trifluoroacetic acid as judged from absorption, electron spin resonance studies, and the cation radicals that formed absorb strongly in the NIR region. TD‐DFT studies corroborate with the experimental observations.
The Collaborative Approach for Asian Americans and Pacific Islanders Research and Education (CARE): A recruitment registry for Alzheimer's disease and related dementias, aging, and caregiver‐related research
Authors: Ta Park Van M. , Meyer Oanh L. , Tsoh Janice Y. , Kanaya Alka M. , Tzuang Marian , Nam Bora , Vuong Quyen , Bang Joon , Hinton Ladson , Gallagher‐Thompson Dolores , Grill Joshua D. 
Published: April 2022

AbstractIntroductionClinical research focused on aging, Alzheimer's disease and related dementias (ADRD), and caregiving often does not recruit Asian Americans and Pacific Islanders (AAPIs).MethodsWith funding from the National Institute on Aging, we designed and launched the Collaborative Approach for AAPIs Research and Education (CARE), a research recruitment registry to increase AAPIs’ participation in ADRD, aging, and caregiving research. We present the design of this novel recruitment program.ResultsCARE uses community‐based participatory research methods that are culturally and linguistically appropriate. Since CARE's launch, it has enrolled >7000 AAPIs in a 1‐year period. The majority enrolled in CARE via community organizations and reported never having participated in any kind of research before. CARE also engages researchers by establishing a recruitment referral request protocol.DiscussionCARE provides a promising venue to foster meaningful inclusion of AAPIs who are under‐represented in aging and dementia‐related research.
In Situ Prodrug Activation by an Affibody‐Ruthenium Catalyst Hybrid for HER2‐Targeted Chemotherapy
Authors: Zhao Zhennan , Tao Xuan , Xie Yanxuan , Lai Qi , Lin Wenkai , Lu Kai , Wang Jinhui , Xia Wei , Mao Zong‐Wan 
Published: April 2022

AbstractTransition‐metal catalysts exhibit great potential as therapeutic agents to inhibit tumor growth. However, the precise delivery and in situ catalysis are challenging in catalytic medicine. Herein, we report an anti‐HER2 affibody‐ruthenium catalyst hybrid, named Ru‐HER2 for selective and effective killing of cancer cells. Ru‐HER2 binds to the HER2 receptor on a tumor cell and in situ catalyzes the activation of gemcitabine prodrug, resulting in enhanced selectivity in suppression of tumor growth and reduction of side effects. Immunoblotting reveals that Ru‐HER2 in combination with gemcitabine prodrug can not only induce DNA damage, but also effectively block the HER2 signaling pathway in cancer cells. Therefore, the HER2‐targeted chemotherapy exhibits substantially high anticancer activity toward HER2‐positive cancer cells in vitro and in vivo. In a word, we report the first affibody‐ruthenium catalyst hybrid and reveal its potential for effective HER2‐targeted cancer chemotherapy.
Charge‐Compensation in a Displacement Mg2+ Storage Cathode through Polyselenide‐Mediated Anion Redox
Authors: Qu Xuelian , Du Aobing , Wang Tao , Kong Qingyu , Chen Guodong , Zhang Zhonghua , Zhao Jingwen , Liu Xin , Zhou Xinhong , Dong Shanmu , Cui Guanglei 
Published: April 2022

AbstractChalcogenides have been viewed as important conversion‐type Mg2+‐storage cathodes to fulfill the high volumetric energy density promise of magnesium (Mg) batteries. However, the low initial Columbic efficiency and the rapid capacity degradation remain challenges for the chalcogenide cathodes, as the clear Mg2+‐storage mechanism has yet to be clarified. Herein, we illustrate that the charge storage mechanism of the Cu2−xSe cathode is a reversible displacement reaction along with a polyselenide (PSe) mediated solution process of anion‐compensation. The unique anion redox improves charge storage, while the dissolution of PSe also leads to performance degradation. To address this issue, we introduce Mo6S8 into the Cu2−xSe cathode to immobilize PSe, which significantly improves performance, especially the reversible capacity (from 140 mAh g−1 to 220 mAh g−1). This work provides inspiration for the modification of the Mg2+‐storage cathode, which is a milestone for high‐performance Mg batteries.
Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols
Authors: Colgan Avene C. , Proctor Rupert S. J. , Gibson David C. , Chuentragool Padon , Lahdenperä Antti S. K. , Ermanis Kristaps , Phipps Robert J. 
Published: April 2022

AbstractCatalytic enantioselective Minisci reactions have recently been developed but all instances so far utilize α‐amino radical coupling partners. We report a substantial evolution of the enantioselective Minisci reaction that enables α‐hydroxy radicals to be used, providing valuable enantioenriched secondary alcohol products. This is achieved through the direct oxidative coupling of two C−H bonds on simple alcohol and pyridine partners through a hydrogen atom transfer (HAT)‐driven approach: a challenging process to achieve due to the numerous side reactions that can occur. Our approach is highly regioselective as well as highly enantioselective. Dicumyl peroxide, upon irradiation with 390 nm light, serves as both HAT reagent and oxidant whilst selectivity is controlled by use of a chiral phosphoric acid catalyst. Computational and experimental evidence provide mechanistic insight as to the origin of selectivity, revealing a stereodetermining deprotonation step distinct from the analogous reaction of amide‐containing substrates.
Enhancing Metalating Efficiency of the Sodium Amide NaTMP in Arene Borylation Applications
Authors: Bole Leonie J. , Tortajada Andreu , Hevia Eva 
Published: April 2022

AbstractThough LiTMP (TMP=2,2′,6,6′‐tetramethylpiperidide) is a commonly used amide, surprisingly the heavier NaTMP has hardly been utilised. Here, by mixing NaTMP with tridentate donor PMDETA (N,N,N′,N′′,N′′‐pentamethyldiethylenetriamine), we provide structural, and mechanistic insights into the sodiation of non‐activated arenes (e.g. anisole and benzene). While these reactions are low yielding, adding B(OiPr)3 has a profound effect, not only by intercepting the CAr‐Na bond, but also by driving the metalation reaction towards quantitative formation of more stabilized sodium aryl boronates. Demonstrating its metalating power, regioselective C2‐metalation/borylation of naphthalene has been accomplished contrasting with single‐metal based protocols which are unselective and low yielding. Extension to other arenes allows for in situ generation of aryl boronates which can then directly engage in Suzuki–Miyaura couplings, furnishing a range of biaryls in a selective and efficient manner.
Catalytic Decomposition of Long‐Chain Olefins to Propylene via Isomerization‐Metathesis Using Latent Bicyclic (Alkyl)(Amino)Carbene‐Ruthenium Olefin Metathesis Catalysts
Authors: Nagyházi Márton , Lukács Ádám , Turczel Gábor , Hancsók Jenő , Valyon József , Bényei Attila , Kéki Sándor , Tuba Róbert 
Published: April 2022

AbstractOne of the most exciting scientific challenges today is the catalytic degradation of non‐biodegradable polymers into value‐added chemical feedstocks. The mild pyrolysis of polyolefins, including high‐density polyethylene (HDPE), results in pyrolysis oils containing long‐chain olefins as major products. In this paper, novel bicyclic (alkyl)(amino)carbene ruthenium (BICAAC−Ru) temperature‐activated latent olefin metathesis catalysts, which can be used for catalytic decomposition of long‐chain olefins to propylene are reported. These thermally stable catalysts show significantly higher selectivity to propylene at a reaction temperature of 75 °C compared to second generation Hoveyda–Grubbs or CAAC−Ru catalysts under ethenolysis conditions. The conversion of long‐chain olefins (e.g., 1‐octadecene or methyl oleate) to propylene via isomerization‐metathesis is performed by using a (RuHCl)(CO)(PPh3)3 isomerization co‐catalyst. The reactions can be carried out at a BICAAC−Ru catalyst loading as low as 1 ppm at elevated reaction temperature (75 °C). The observed turnover number and turnover frequency are as high as 55 000 and 10 000 molpropylene molcatalyst−1 h−1, respectively.
Oil separation process of Citrus sinensis orange: simulation and techno‐economic evaluation
Authors: Santos Victor de M , Calado Veronica M. A. , Bojorge Ninoska 
Published: April 2022

AbstractThis work focuses on modeling, simulation and techno‐economic analysis, motivated by the great potential for transforming the residues of sweet orange peel (Citrus sinensis) from the food industry into products with higher added value. A techno‐economic analysis of the extraction process of limonene and linalool using supercritical CO2 in a continuous flow was carried out on an industrial scale. The process was simulated using the Soave–Redlich–Kwong (SRK) thermodynamic equilibrium model. In order to find the maximum separation process yield, a 33 factorial design was used to analyze the main process factors, which were temperature, pressure, and solvent feed rate. Limonene was the principal component extracted. The optimum conditions for limonene extraction using a 12‐stage differential extractor were 50°C, 1930 kg h−1 and pressure around 74 bar, representing a 99.5% extraction from orange peel oil. The analyzed process conditions showed that the solution became saturated when the CO2/oil feed ratio was >19.7 kg h−1. Under these conditions, the cost of manufacturing was US$148.04 per kg of orange peel oil. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd
Approaches to purification and concentration of rAAV vectors for gene therapy
Authors: Belova Lyubava , Kochergin‐Nikitsky Konstantin , Erofeeva Anastasia , Lavrov Alexander , Smirnikhina Svetlana 
Published: April 2022

AbstractRecombinant adeno‐associated viruses (rAAVs) are promising vectors for the delivery of various genetic constructs into eukaryotic cells. rAAVs have a number of properties that make it possible to successfully use them both in vitro and in vivo. Purification and concentration of rAAV vectors are critical for achieving high viral titer, stability, efficiency, and purity. This review systematically analyses all available purification approaches. The purification methods described in this work differ substantially from each other in mechanisms, efficiency, labor time, and cost. Researchers have to choose a purification algorithm depending on the purpose of their work. We strive to simplify the choice of the necessary and sufficient technique based on the experimental needs and available resources of the laboratory.
Novel Hydrazone Derivatives of 3‐Bromopyruvate: Synthesis, Evaluation of the Cytotoxic Effects, Molecular Docking and ADME Studies
Authors: Beygi Farzaneh , Mostoufi Azar , Mojaddami Ayyub 
Published: April 2022

AbstractA series of 3‐bromopyruvate (3‐BP) derivatives were synthesized to develop new potent anticancer agents. The chemical structures of the compounds were characterized using FT‐IR, 1H‐, 13C‐NMR spectroscopy, and elemental analysis (CHN). Their cytotoxic activities were investigated against four cancer cell lines, including colon (SW1116), breast (MDA‐MB‐231), lung (A549), and liver (HepG2) cancer cell lines. Among the synthesized compounds, 3b showed promising cytotoxic activity compared to 3‐BP, with IC50 values of 16.3 μM, 19.1 μM, 27.8 μM, and 14.5 μM against A549, MDA‐MB‐231, SW1116 and, HepG2 cell lines, respectively. Furthermore, the effect of these compounds on MCF‐10A (a normal breast cell lines) was investigated to determine their selectivity between tumorigenic and non‐tumorigenic cells. Since the 3‐BP inhibits hexokinase II (HK II), molecular docking of 3‐BP derivatives was carried out using AutoDock 4.2. The binding energies of these derivatives were greater than 3‐BP, indicating that they had a higher affinity for HK II. For validation of docking, a 40 ns MD simulation was performed. SwissADME was used to predict pharmacokinetics, drug‐likeness, and ADME parameters of the screened compounds. The results demonstrated that these derivatives are suitable candidates for developing orally potent HK II inhibitors.
Endophytic Fungi as a Source of Antiviral Compounds – A Review
Authors: Lacerda Íris Carolina dos Santos , Polonio Júlio Cesar , Golias Halison Correia 
Published: April 2022

AbstractEndophytic fungi are a rich source of secondary metabolites. The interactions between endophytes and their hosts lead to the production of several bioactive substances grouped into different classes, each having a wide variety of effects against various pathogens. The metabolites obtained from these organisms include steroids, alkaloids, phenols, isocoumarins, xanthones, quinones, and terpenoids, among others. These substances are known to have antibiotic, antiparasitic, antifungal, and antiviral effects. This review summarizes secondary metabolites with antiviral effects produced by endophytic fungi and highlights the importance of research in developing novel antiviral substances. We demonstrate that endophytic fungi are a rich source of secondary metabolites that combat pathologies caused by viruses. Optimizing practical and biotechnological screening tools for the research of these metabolites will provide promising drugs to combat these infections.
Efficacy of larger valve sizing with underfilling in balloon‐expandable transcatheter aortic valve replacement
Authors: Kawaguchi Tomohiro , Miyoshi Toru , Hayashi Masaomi , Ishizu Kenichi , Ugawa Satoko , Nosaka Kazumasa , Isotani Akihiro , Doi Masayuki , Shirai Shinichi , Ando Kenji 
Published: April 2022

AbstractObjectivesTo investigate the efficacy and safety of larger valve sizing beyond the commercially recommended annular range in transcatheter aortic valve replacement (TAVR) with balloon‐expandable transcatheter heart valve (THVs).BackgroundThe clinical implications of larger balloon‐expandable THV implantation with underfilling are poorly evaluated.MethodsThis retrospective study included 692 consecutive patients who underwent TAVR with SAPIEN3. A total of 271 patients who underwent SAPIEN 3 implantation were analyzed based on three border zones (Zone 1: 300–345 mm2, 23 vs. 20 mm; Zone 2: 400–430 mm2, 26 vs. 23 mm; Zone 3: 500–546 mm2, 29 vs. 26 mm). The primary endpoint was the effective orifice area (EOA) assessed by echocardiography at 1 year, and secondary endpoints were a 30‐day mortality rate, procedural complications during TAVR, and a composite of death from any cause and heart failure requiring rehospitalization at 1 year.ResultsAt 1‐year follow‐up, the EOA in the larger valve groups was greater than that in the recommended valve group in each zone (Zone 1: 1.45 ± 0.03 vs. 1.06 ± 0.06 cm2, p < 0.001; Zone 2: 1.83 ± 0.05 vs. 1.41 ± 0.05 cm2, p < 0.001; Zone 3: 1.93 ± 0.07 vs. 1.69 ± 0.07 cm2, p = 0.02). No significant difference in the secondary endpoint was observed in any of the zones.ConclusionsImplantation of the out‐of‐range larger SAPIEN 3 THVs with underfilling was associated with greater EOA at the 1‐year follow‐up and feasible in the selected patients.
Bedside intra‐aortic balloon pump insertion in cardiac intensive care unit: A single‐center experience
Authors: Baldetti Luca , Beneduce Alessandro , Boccellino Antonio , Pagnesi Matteo , Barone Giuseppe , Gallone Guglielmo , Napolano Antonio , Gramegna Mario , Calvo Francesco , Pazzanese Vittorio , Sacchi Stefania , Cappelletti Alberto M. 
Published: April 2022

AbstractBackgroundIn contemporary Cardiac Intensive Care Unit (CICU), bedside intra‐aortic balloon pump (IABP) insertion under echocardiographic guidance may be an attractive option for selected patients with cardiogenic shock (CS). Currently available data on this approach are limited.AimThis study aimed to assess the feasibility and safety of bedside IABP insertion, as compared to fluoroscopic‐guided insertion in the Catheterization Laboratory (CathLab), and to describe the clinical features of patients receiving bedside IABP insertion using a standardized technique in real‐world CICU practice.MethodsWe prospectively evaluated all patients admitted the CICU who received transfemoral IABP between June 2020 and October 2021. The overall study cohort was divided according to implant strategy in bedside and CathLab groups. The primary outcome was correct radiographic IABP positioning at the first bedside chest X‐ray obtained after insertion. Secondary outcomes included IABP‐related complications.ResultsAmong 115 patients, bedside IABP insertion was performed in 35 (30.4%) cases, mainly presenting with CS‐related to acute decompensated heart failure (ADHF) (68.6 vs 33.8%; p < 0.001), with lower LVEF, higher proportion of right ventricular involvement and higher need of inotropes/vasopressors, compared to those receiving CathLab insertion. Bedside IABP insertion resulted feasible and safe, with similar rates of correct IABP positioning (82.9 vs. 82.5%; p = 0.963) and IABP‐related major vascular complications (5.7 vs. 5.0%; p = 0.874), as compared to CathLab positioning.ConclusionThis study suggests the feasibility and safety of bedside IABP insertion, which could be of relevant interest in patients with ADHF‐related CS who may not need coronary angiography or other urgent CathLab procedures.
Right cardiac chambers echo‐bubble contrast in a patient with decompression sickness: A case report and a literature review
Authors: Harfoush Allam , Ramadan Mohammad , Hamdallah Hanady 
Published: April 2022

AbstractThe diagnosis of decompression sickness (DCS) is mostly based on clinical suspicion, and there is currently no available modality to fully confirm the diagnosis. However, the use of echocardiography in suspected DCS cases has become more common. In this case, transthoracic echocardiography (TTE) was used to detect microbubbles in the right cardiac chambers and monitor the patient after hyperbaric oxygen therapy (HBOT), suggesting the possible applicability of TTE in diagnosing and monitoring DCS patients. This report describes a 54‐year‐old Fisherman who was referred to the emergency department with dyspnea and mild confusion after a rapid ascent of a saturation dive at 50 m sea depth. After the initial evaluation, he was assessed using TTE to exclude the presence of structural heart disease, where it surprisingly showed spontaneous echo contrast inside the right cardiac chambers similar to agitated saline echo testing. The patient was then admitted for HBOT and follow‐up; rapid improvement was noticed after the first HBOT session and the TTE findings were fully resolved. TTE could be considered in the initial workup when DCS is suspected, and it might have a role in monitoring DCS patients if echocardiographic findings of bubble formation were documented in the pre‐hyperbaric therapy settings.
Axillary lymph‐node metastases as the primary presentation of high‐grade serous ovarian carcinoma: A case report
Authors: Mirzaei Monire , Eshraghi Abbas , Ghoddoosi Mahdiieh , Fatemi Maedeh Alsadat , Eshraghi Azhar , Shenavaei Sara , Fazilat‐panah Danial 
Published: April 2022

AbstractWe reported a female presented with an initial diagnosis of metastatic axillary lymph‐node carcinoma that comprehensive assessments revealed a definitive diagnosis of high‐grade serous ovarian carcinoma as the primary tumor.
Atypical manifestations of cutaneous leishmaniasis in a boy from Afghanistan
Authors: Fakhar Mahdi , Rasooli Seyed Abobaker , Banimostafavi Elham Sadat , Soleymani Mostafa 
Published: April 2022

AbstractCutaneous leishmaniasis is one of the most common forms of leishmaniasis in Afghanistan, which is caused by different Leishmania species that are transmitted to humans by sandflies. Its clinical manifestations are very diverse and depend on a variety of parasite and host factors.
Myocarditis following AstraZeneca (an adenovirus vector vaccine) COVID‐19 vaccination: A case report
Authors: Hassanzadeh Shakiba , Sadeghi Somayeh , Mirdamadi Ahmad , Nematollahi Alireza 
Published: April 2022

AbstractCoronavirus disease‐19 (COVID‐19) vaccines are massively administered globally and some adverse events, such as myocarditis, are being reported. Most of the reported cases of post‐vaccination myocarditis have occurred following mRNA vaccinations. However, there have also been recent reports of myocarditis following adenovirus vector vaccinations. We present a case of a 32‐year‐old female patient who developed myocarditis following the administration of the first dose of the AstraZeneca vaccine. The patient developed inappropriate exertional tachycardia and exertional dyspnea from Day 3 and was diagnosed with myocarditis by subsequent echocardiography about 3 months later. We are unable to confirm a direct association between myocarditis and AstraZeneca vaccination. However, we would like to increase awareness regarding the possibility of developing myocarditis following AstraZeneca vaccination.
Cystic adventitial disease of popliteal artery, the both sides of the coin: Arterial resection vs cyst excision
Authors: Nieto Luis Alejandro , Cabrera Vargas Luis Felipe , Lozada‐Martínez Ivan David , Guardo‐Carmona Daniela , Contreras Martin , Pedraza Mauricio , Narvaez‐Rojas Alexis Rafael 
Published: April 2022

AbstractAdventitial cystic disease (ACD) is a rare form of non‐atherosclerotic arterial stenosis. This entity accounts only for 0.1% of all vascular diseases and affects the popliteal artery unilaterally in 85% of the cases. The options for treatment ACD include excision of cysts, removal of the affected arterial segment with vein graft reconstruction or radiological aspiration. We present two cases of ACD of the popliteal artery and its subsequent management and discuss the pros and cons of the treatment's strategies.
Use of the flexible bronchoscope and Infrared Red Intubation System in a known difficult airway in the intensive care unit
Authors: Hannig Kjartan Eskjaer , Kristensen Michael Seltz , Hauritz Rasmus Wulff , Jessen Christian , Grejs Anders Morten 
Published: April 2022

AbstractThis case report describes a patient in the ICU in need of urgent intubation, for whom video laryngoscope‐guided intubation had previously failed. The Infrared Red Intubation System (IRRIS) may enhance the chance of successful flexible bronchoscope intubation, especially when performed by non‐expert anesthesiologists.