bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecast of Global Solar Radiation on a Horizontal Surface by ANN for the City of Batna Algeria
Authors: Yahiaoui Samah , Assas ouarda 
Published: September 2022

Abstract
Solar energy is one of the longest-standing renewable in the world. It is available at no charge and could easily be exploited to reduce dependence on hydrocarbon-based energy. Solar radiation data plays an important role in the design, size, and efficiency of energy systems and renewable. However, these data are not available in all cases, particularly in isolated areas. Therefore, prediction of solar radiation values is often the only practical way to obtain such data. In fact, the measured sequences of radiation values are only available for some locations or regions in each country. Neural networks are classified among the techniques of artificial intelligence, its simulation of human reasoning characterizes it and neural networks have contributed to the development of several areas. In prediction, neural networks are used to solve complex forecasting problems. In this work, fifteen neural models are implemented for the modeling and prediction of global solar radiation over a horizontal surface using neural networks. The meteorological parameters are: duration of sunshine (S), hours of light (S0), total extraterrestrial solar radiation, temperature and humidity. Batna has been selected for this study, with its ten years (1996–2005) meteorological datasets collected from the HelioClim1 (HC1) database. The obtained results show that the news neuronal models are efficient for predicting daily global solar radiation with good measurement precision in this town.
Observational Real-Life Study on Regorafenib in Recurrent Glioblastoma: Does Dose Reduction Reduce Toxicity While Maintaining the Efficacy?
Authors: Rudà Roberta , Bruno Francesco , Pellerino Alessia , Pronello Edoardo , Palmiero Rosa , Bertero Luca , Crasto Stefania , Polo Valentina , Vitaliani Roberta , Trincia Elena , Internò Valeria , Porta Camillo , Soffietti Riccardo 
Published: September 2022

Abstract
Purpose: In the phase 2 REGOMA trial,
regorafenib improved overall survival, as compared with lomustine,
in glioblastoma (GBM) patients at first progression after
chemoradiation. Recently, some real-life trials showed similar
impact on survival but a higher rate of adverse events than in
REGOMA, thus raising concerns over tolerability. The aim of this
study was to assess the efficacy and tolerability of a lower
intensity regorafenib regimen.

Patients and Methods: Regorafenib daily dose
was gradually increased from 80 to 160 mg across the first 2
cycles. Progression-free survival (PFS) and overall survival (OS)
were defined as time from regorafenib initiation and disease
progression or death. Results: Sixty-six GBM
patients were included. Median age was 60.0 years. Median PFS and
OS following regorafenib were 2.7 and 7.1 months, respectively.
Best RANO response to regorafenib were partial response (PR) in 10
(15.1%), stable disease in 17 (25.8%), and progressive disease in
39 (59.1%) patients. Forty-six (69.7%) patients presented adverse
events of any grade, and 21 (31.8%) grade 3-4 toxicity. In a
multivariable analysis, higher age and absence of MGMTp
methylation were significantly associated with poorer disease
control after regorafenib.

Conclusions: Our study is the largest
observational real-life study on the use of regorafenib. Our lower
intensity regimen proved as effective as the standard 160 mg daily
schedule (mPFS and mOS being 2.7 vs 2.0 months and 7.1 vs 7.4
months in our study vs REGOMA, respectively). Moreover, we observed
a higher rate of PRs as compared with REGOMA (15.0% versus
3.0%).
Predicting the secondary metabolic potential of microbiomes from marker genes using PSMPA
Authors: Wei Bin , Zhou Zhen-Yi , Lai Cong , Du Ao-Qi , Hu Gang-Ao , Yu Wen-Chao , Yu Yan-Lei , Chen Jian-Wei , Zhang Hua-Wei , Wu Qi-Hao , Xu Xue-Wei , Xuan Qi , Wang Hong 
Published: September 2022

Abstract
Background: The efficient discovery of novel antibiotics is of great significance for us to fight against drug-resistant pathogens. Previously, a great deal of time and effort has been spent on screening and isolating novel antibiotic-producing bacteria from complex environmental samples, and the secondary metabolic potential of microbiomes could only be investigated after their genome sequences were available.
Results: Here, we present PSMPA, a web server and a standalone tool, for predicting the numbers of each class of bacterial secondary metabolite biosynthetic gene clusters (BGCs) in environmental samples using 16S rRNA gene amplicons, which could prioritize samples and bacterial strains with high potential to produce novel antibiotics at an early stage. The pipeline integrated PICRUSt2 and BLASTn, and relied on a comprehensive bacterial BGC atlas which contains 1,295,905 BGCs from 216,408 bacterial genomes. PSMPA showed good performance with the accuracy largher than 80% when applied to predict the BGC profiles in 5,000 randomly selected bacterial genomes. Then, PSMPA was applied to depict the distribution of BGCs in microbiomes from human gut, sea water, deep-sea sediments, and soil samples from several independent datasets, which uncovered plenty of novel strains that are rich in BGCs.
Conclusions: We presented a comprehensive bacterial BGC atlas and demonstrated that PSMPA is a usefull tool for predicting the secondary metabolic potential of microbiomes from marker genes. PSMPA would facilitate the efficient discovery of novel microbial secondary metabolites and enrich the resource for amplicon sequencing-based functional analysis. The PSMPA is available at https://www.psmpa.net.
A salvage technique using a fibrous sheath to avoid the loss of the central veins in cases of pediatric intestinal failure
Authors: Kondo Takuya , Nagata Kouji , Jimbo Takahiro , Kono Jun , Kawakubo Naonori , Obata Satoshi , Yoshimaru Koichiro , Miyoshi Kina , Esumi Genshiro , Matsuura Toshiharu , Masumoto Kouji , Tajiri Tatsuro , Taguchi Tomoaki 
Published: September 2022

Abstract
Purpose
The number of accessible central veins (CVs) affects the prognosis of patients with intestinal failure (IF). The loss of residual CVs should be avoided. We therefore evaluated the efficacy of a new CV catheter-exchange technique using a subcutaneous fibrous sheath (FS) in pediatric IF patients.
Methods
We retrospectively collected the CV catheter (CVC) data of pediatric IF patients managed from January 2009 to December 2019. The data were divided into two groups; Groups 1 (CVCs placed with the FS method) and Group 2 (CVCs placed by the primary or another insertion). The main outcome was the CVC indwelling time.
Results
Eighty-five CVCs were analyzed. The FS method was attempted in 47 cases and succeeded in 40 (85%). No significant difference was observed between the groups regarding characteristics. A log-rank test revealed an equivalent CVC indwelling time between the two groups (Group 1: 268 [126–588] days vs. Group 2: 229 [126–387] days, p = 0.256).
Conclusions
The FS method is highly recommended for pediatric IF patients, as its attempt showed a high success rate with an indwelling time equivalent to primary insertion. The FS method leads to the prolonged use of a single CV and thereby contributes to improving the outcomes of pediatric IF patients.
Diabetes prevalence and associated factors in the adult population aged 25–64 in the Humbo districts of Woliata Zone
Authors: Abebe Samson , Paulos Wondimagegn , Tschopp Rea 
Published: September 2022

AbstractBackground The burden of disease caused by NCDs is quickly growing in emerging nations, with substantial social, economic, and health repercussions. However, data on the prevalence of diabetes and related variables among adults aged 25–64 years in Ethiopia, particularly in drought-stricken areas, is limited. The goal of this study is to find out how common diabetes is and what variables contribute to it in adults aged 25 to 64. Methods From January to February 2020, a community-based cross-sectional survey was undertaken among adults aged 25–64 years in Humbo district, Southern Ethiopia. 587 people were chosen using a multi-stage sampling process. Weight, height, and fasting blood glucose levels were all measured. To enter data into a computer, Epi Data version 3.1 was utilized, which was subsequently exported to SPSS version 20 for analysis. Descriptive statistics, bivariate and multivariate logistic regression analyses were performed, and statistical significance was determined at a p-value < 0.05. Results Diabetes was found in 5.9% of the research participants (95 percent CI: 3.8–7.8). Age 45–54 (AOR = 4.80, 1.25, 18.32), physical inactivity (AOR = 5.33, 1.37, 20.72), family history of diabetes mellitus (AOR = 6.34, 95 percent CI: (2.43, 16.55), and obesity (AOR = 3.26, 95 percent CI: (1.43, 7.42) were all significantly associated with diabetes, according to multivariable logistic regression. Conclusion The findings demonstrated the need of implementing educational public policies to encourage population behavior changes in order to prevent and control diabetes.
Correlation between Serum testosterone level and erythrocytosis in adolescent males- A Cross-Sectional study
Authors: Ben Ariel , Rana Abu Arisha , Tal Bechor Ariel , Michael Ben-Acon , Sharon Nechama , Yana Moshe 
Published: September 2022

Abstract
Backround: Androgens and testosterone can induce erythrocytosis in several mechanisms. Adolescent males often present to primary clinics with an elevated Red Blood Cell values without Hemoglobin abnormalities. We investigated the correlation between serum testosterone levels and red blood cell values.
Methods: 91 adolescents who were referred to the Emergency department were included in the trial, for which a complete blood count and serum testosterone were obtained, along with assessing Tanner score. Patients were divided into two groups with high and low red blood cell count. Mann -Whitney U test was performed to compare Serum testosterone level and Tanner score between the groups. Pearson’s correlation coefficient was calculated to determine the correlation between red blood cell count and Testosterone levels.
Results: Testosterone levels was higher in the erythrocytosis group 14.05 (SD 5.53) vs non erythrocytosis group 11.94 (SD 7.38) although it did not meet statistical significance (p-value = 0.168). There is a weak positive correlation (Pearson’s R = 0.146) between testosterone and erythrocyte levels.
Conclusion: In healthy adolescent males, whose serum testosterone levels are within normal range we observed erythrocytosis in 22% of patients. Testosterone levels was positively correlated with the Red blood cell count.
Trial Registration: Trial was registrated in the Israeli ministery of health database – date 27/10/2020 – MOH_2020-10-27-009444
The effect of low doses of Aspirin on the occurrence of rectal aberrant crypt foci (ACF)
Authors: Kowalczyk Marek , Sigorski Dawid , Dyśko Łukasz , Zieliński Ewa , Lucka Dana Zupanovich , Klepacki Łukasz 
Published: September 2022

Abstract
Purpose: Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic and, in some cases, neoplastic lesions in human colons. Many studies have confirmed the reduction of ACFs and colorectal adenomas after treatment with acetylsalicylic acid (ASA).
The objective was to compare the incidence of rectal ACFs and colorectal adenomas in a group of patients taking ASA.
Methods: Colonoscopy, combined with rectal mucosa staining with 0.25% methylene blue, was performed on 131 patients. The number of rectal ACF in the colon was divided into three groups: ACF < 5; 5 < ACF < 10; and ACF > 10. Patients were divided into two groups: the "ASA" group - subjects taking ASA 75mg daily for ten years; and "No ASA" group - subjects not taking ASA chronically. The incidence of different types of rectal ACF and colorectal polyps in both groups of subjects was determined.
Results: Normal ACF was found in 12.3 in the study group vs 87.7% control group, hyperplastic 22.4 vs 77.6%, dysplastic 25 vs 75%, mixed 0 vs 100%. Treatment with ASA affects the occurrence of colorectal adenomas. The amount of dysplastic ACFs was higher in the control group than in the study group. The increase in dysplastic ACFs decreases with age in both groups, with the increase greater in those not taking ASA.
Conclusions: Patients who take persistent, chronic (>10 years) low doses of ASA have a lower total number of all types of rectal ACFs and adenomas compared to the control group.
Patient Satisfaction and Cost Savings Analysis of the Telemedicine Program within a Neuro- Oncology Program
Authors: Liu James K. C. , Kang Richard , Bilenkin Arkady , Prorock Rachel , Whiting Junmin , Patel Krupal B. , Beer-Furlan Andre , Naso Cristina , Rogers Andrea , Castro Xavier Baez , Peguero Edwin , Mokhtari Sepideh , Tran Nam , Etame Arnold , Pina Yolanda , Spiess Philippe E. , Forsyth Peter , Vogelbaum Michael A. 
Published: September 2022

Abstract
PURPOSE: Unique challenges exist in the utilization of telemedicine for neurological and surgical specialties. We examined the differences in patient satisfaction for telemedicine versus in-person visits within a Neuro-Oncology Program to assess whether there was a difference between surgical and medical specialties. We also examined the potential cost savings benefits of utilizing telemedicine.
METHODS: 1189 Press Ganey surveys in the Department of Neuro-Oncology (982 in-person and 207 telemedicine) by surgical and medical neuro-oncology patients between 04/01/2020 and 06/30/2021 were reviewed. Survey results were divided into 4 categories (Access, Provider, Technology (telemedicine only), and Overall Satisfaction). Results were analyzed for the impact of telemedicine versus in-person visits, and gender, age, insurance, and specialty. Cost savings were calculated based on potential travel distance and lost productivity.
RESULTS: Survey results from telemedicine visits demonstrated that patients with private insurance returned higher scores in the Provider (p=0.0089), Technology (p=0.00187), and Overall (p=0.00382) categories. Surgical visits returned higher scores for Access (p=0.0015), Technology (p=0.0002), and Overall (p=0.0019). When comparing telemedicine to in-person scores, in-person scored higher in Provider (p=0.0092) for all patients, while in-person scored higher in Access (p=0.0252) amongst surgical patients. Cost analysis revealed that telemedicine allowed patients to save an average of 3.7 to 4.8 hours per visit time and a potential loss of productivity of up to $223.27 ±171.41.
CONCLUSIONS: Telemedicine yields equivalent patient satisfaction when employed in surgical as compared to medical Neuro-Oncology patients with the potential to lessen the financial and time burden on neuro-oncology patients.
Propagation of different kinds of non-linear ion-acoustic waves in Earth’s magnetosphere
Authors: Alharthi N S , Tolba R E 
Published: September 2022

Abstract
The non-linear propagation of different kinds of ion-acoustic waves (IAWs) in multi-component plasma involving proton beam, positive ions and isothermal electrons has been studied. Using the derivative expansion method of basic equations, namely the hydrodynamic and Poisson equations, they are reduced to a single evolution equation of the non-linear Schrödinger (NLS) equation. By applying this model to plasma formed in Earth’s magnetosphere, different waves can be predicted that express the properties of the plasma. Using the separating variables method and the G /G-expansion method, we derived the exact analytical solutions to the evolution equation by using different solution regions in which non-linear waves are defined. A comparison has been made between the solutions describing the differential equation in each region in which the solution can appear using the data on the Earth’s magnetosphere in the study by Alotaibi et al. (2021).
Possibilities and Limitations of CNV Interpretation Software and
Algorithms in Homo Sapiens
Authors: Zelenova Maria A. , Iourov Ivan Y. 
Published: September 2022

Background:
Technical advances and cost reduction have allowed for the worldwide popularity
of array platforms. Otherwise called “molecular karyotyping”, it yields a large amount of CNV
data, which is useless without interpretation.

Objective:
This study aims to review existing CNV interpretation software and algorithms to reveal
their possibilities and limitations.

Results:
Open and user-friendly CNV interpretation software is limited to several options, which mostly
do not allow for cross-interpretation. Many algorithms are generally based on the Database of Genomic
Variants, CNV size, inheritance data, and disease databases, which currently seem insufficient.

Conclusion:
The analysis of CNV interpretation software and algorithms resulted in a conclusion that it
is necessary to expand the existing algorithms of CNV interpretation and at least include pathway and
expression data. A user-friendly freely available CNV interpretation software, based on the expanded
algorithms, is yet to be created.
Design and Analysis of a Spraying Robot
Authors: M. Jasim Fatima , M. Ali Malik , H. Hamad Ali 
Published: September 2022

An indoor spraying robot is built in this research to solve numerous challenges associated with manual spraying. The mechanical, hardware and essential technologies used are all detailed and designed. The proposed spraying robot's conceptual design is split into two parts: hardware and software. The mechanical design, manufacturing, electrical, and electronics systems are described in the hardware part, while the control of the robot is described in the software section. This robot's kinematic and dynamic models were developed using three links that move in the x, y, and z directions. The robot was then designed using SolidWorks software to compute each connection's deflection and maximum stresses. The characteristics of the stepper motors, power screw and belt drive, are calculated. Finally, an Arduino-Nano controller and stepper motor actuators were used to build and run the robot. As a result, the robot was able to move smoothly vertically and horizontally, according to the findings of the experiments as shown in figures 22, 23, 24, and 25. These figures showed the position and velocity curves of the links of the robot.
Emprendimiento y empleabilidad en la industria de la fertilidad: el caso de las gestantes “subrogadas” de California (EUA)
Authors: Rivas Rivas Ana María , Ayala Rubio Ariadna , Álvarez Plaza Consuelo 
Published: September 2022

<p class="p2">Los avances tecnológicos, las dificultades en la adopción internacional y las diferencias legislativas han transformado el acceso y las prácticas relativas a la atención reproductiva transnacional, desarrollándose un mercado en el que circula material genético y personas con deseos reproductivos que no pueden verse cumplidos en sus países de origen. En dicho contexto, este capítulo explora la gestación por sustitución desde el punto de vista de las mujeres que gestan para terceros en California, Estados Unidos, centrándose en los discursos de aquellas que fundan sus propias empresas. La práctica de la gestación por sustitución en California nos permitirá analizar el fenómeno de la “empresarialización” y empleabilidad de las gestantes por sustitución (la liberalización del mercado reproductivo, la jurisprudencia, la doctrina de la intención, la aceptación social de esta práctica y los marcos morales que permiten a los actores sociales darle sentido y legitimidad social).<span class="Apple-converted-space"> </span></p>
Longitudinal Associations of Air Pollution With Body Size and Composition in Midlife Women: The Study of Women’s Health Across the Nation
Authors: Wang Xin , Karvonen-Gutierrez Carrie A. , Gold Ellen B. , Derby Carol , Greendale Gail , Wu Xiangmei , Schwartz Joel , Park Sung Kyun 
Published: September 2022

OBJECTIVE
We examined longitudinal associations of air pollution exposure, including fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3), with weight, BMI, waist circumference, fat mass, lean mass, and proportion fat mass in midlife women.

RESEARCH DESIGN AND METHODS
The study population included 1,654 White, Black, Chinese, and Japanese women from the Study of Women’s Health Across the Nation, with the baseline median age of 49.6 years, followed from 2000 to 2008. Annual air pollution exposures were assigned by linking residential addresses with hybrid estimates of air pollutant concentrations at 1-km2 resolution. Body size was measured, and body composition was measured using DXA at approximately annual visits. Linear mixed effects models were used to examine the associations between air pollution and body size and composition measures and whether these associations differed by physical activity.

RESULTS
After adjusting for potential confounders, an interquartile range increase in PM2.5 concentration (4.5 μg/m3) was associated with 4.53% (95% CI 3.85%, 5.22%) higher fat mass, 1.10% (95% CI 0.95%, 1.25%) higher proportion fat mass, and 0.39% (95% CI −0.77%, −0.01%) lower lean mass. Similar associations were also observed for NO2 and O3. Weaker associations of PM2.5 and NO2 with body composition were observed in participants who engaged in more physical activity.

CONCLUSIONS
Our analyses provide evidence that exposure to PM2.5, NO2, and O3, is adversely associated with body composition, including higher fat mass, higher proportional fat mass, and lower lean mass, highlighting their potential contribution to obesity.
Calibration features for power meters of high and microwave frequencies
Authors: Velychko Oleh , Gaman Valentyn , Kursin Serhii 
Published: September 2022

Microwave frequency power measurement is one of the main types of the measurement for measuring instruments and systems in the radio frequency range. Therefore, improving the accuracy of measuring the microwave frequency power requires the establishment of more precise standards, and the development of calibration methods for meters of microwave frequency power is an urgent task. Microwave frequency power standards that are used to calibrate the relevant measuring instruments must ensure high accuracy of the unit size reproduction over a wide measurement and frequency range.
The study allowed determining typical calibration schemes for meters of microwave frequency power. For measurements, the calibration scheme for meters of microwave frequency power by the method of a direct comparison with the help of a calibrator when measuring the absorbed power of microwave frequencies is substantiated and suggested.
The proposed methodology for evaluating the uncertainty of absorbed power measurements can be used when calibrating power meters in the frequency range from 30 MHz to 18 GHz. It allows determining the most significant components of the combined standard uncertainty of the absorbed power measurements of ultrahigh frequencies, as well as to receive the result of the corresponding calibration. This methodology can also be used to evaluate the uncertainty of microwave frequency directional measurements.