bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma atropine concentrations associated with decreased intestinal motility in horses
Authors: Ekstrand Carl , Michanek Peter , Gehring Ronette , Sundell Anna , Källse Annika , Hedeland Mikael , Ström Lena 
Published: September 2022

IntroductionAtropine is an essential part of the treatment protocol for equine uveitis. Topical atropine administration has been associated with decreased intestinal motility and abdominal pain in horses. Experimental studies have indicated that frequent dosing is associated with a higher risk than dosing every 6 h. Unfortunately, no quantitative pharmacodynamic data for inhibition of the equine gut are published.Materials and methodsEight standardbred horses were assigned to receive either atropine or saline (control) to be infused over 30 min in a two-treatment cross-over design. Atropine concentrations in plasma were measured using ultra-high-performance liquid chromatography–tandem mass spectrometry. Intestinal motility was measured using borborygmi frequency and electrointestinography (EIG). Experimental data were analyzed using a non-linear mixed effects model. The model was then used to simulate different dosing regimens.ResultsAtropine significantly decreased borborygmi response and EIG response. Six horses developed clinical signs of abdominal pain. The pharmacokinetic typical values were 0.31, 1.38, 0.69, and 1.95 L/kg·h for the volumes of the central, the highly perfused, the scarcely perfused compartments, and the total body clearance, respectively. The pharmacodynamic typical values were 0.31 μg/L and 0.6 and 207 nV27 cpm for the plasma concentration at 50% of the maximum response and the maximum response and the baseline of cecal EIG response, respectively. Six different dosing regimens of topical atropine sulfate to the eye (0.4 and 1 mg every hour, every 3 h, and every 6 h) were simulated.ConclusionThe IV PK/PD data coupled with simulations predict that administration of 1 mg of topical atropine sulfate administered to the eye every hour or every 3 h will lead to atropine accumulation in plasma and decreased intestinal myoelectric activity. Administration every 6 h predicted a safe dosing regimen in full-sized horses. Clinical studies would be valuable to confirm the conclusions. For smaller equids and horses put at risk for colic due to othercauses, droplet bottles that deliver 40 μl of 1% atropine sulfate per drop or less may be used to lower the risk further.
Barriers and Facilitators in Access to Diabetes, Hypertension, and Dyslipidemia Medicines: A Scoping Review
Authors: Castillo-Laborde Carla , Hirmas-Adauy Macarena , Matute Isabel , Jasmen Anita , Urrejola Oscar , Molina Xaviera , Awad Camila , Frey-Moreno Catalina , Pumarino-Lira Sofia , Descalzi-Rojas Fernando , Ruiz Tomás José , Plass Barbara 
Published: September 2022

Objective: Identify barriers and facilitators in access to medicines for diabetes, hypertension, and dyslipidemia, considering patient, health provider, and health system perspectives.Methods: Scoping review based on Joanna Briggs methodology. The search considered PubMed, Cochrane Library, CINAHL, Academic Search Ultimate, Web of Science, SciELO Citation Index, and grey literature. Two researchers conducted screening and eligibility phases. Data were thematically analyzed.Results: The review included 219 documents. Diabetes was the most studied condition; most of the evidence comes from patients and the United States. Affordability and availability of medicines were the most reported dimension and specific barrier respectively, both cross-cutting concerns. Among high- and middle-income countries, identified barriers were cost of medicines, accompaniment by professionals, long distances to facilities, and cultural aspects; cost of transportation emerges in low-income settings. Facilitators reported were financial accessibility, trained health workers, medicines closer to communities, and patients’ education.Conclusion: Barriers and facilitators are determined by socioeconomic and cultural conditions, highlighting the role of health systems in regulatory and policy context (assuring financial coverage and free medicines); providers’ role bringing medicines closer; and patients’ health education and disease management.
Prevalência de substâncias psicoativas em pacientes vítimas de trauma atendidas em um hospital geral
Authors: Gerbase Fernando Engel , Krützmann Maria Eduarda , Silva Vanessa Becher da , Silva Cristiane Pires da , Sagrilo Octaviano Pereira Zago , Linden Rafael , Antunes Marina Venzon 
Published: September 2022

Objetivos: O trauma é a primeira causa de morte na população jovem e estudar seus fatores de risco é importante para o planejamento de medidas de prevenção. Neste sentido, o objetivo do estudo foi estimar a prevalência de substâncias psicoativas em pacientes atendidos no departamento de emergência de um Hospital Geral por qualquer tipo de trauma no período de 6 meses. Métodos: foi realizado um estudo prospectivo de corte transversal no departamento de emergência de um hospital geral. Foi determinada a alcoolemia e realizada análise toxicológica de substâncias psicoativas por cromatografia liquida de alta eficiência associada a espectrometria de massas (LC-MS/MS) em amostras de sangue colhidas até 6 horas após o trauma. Dados sociodemográficos, tipo e severidade do trauma foram registrados. Resultados: Foram incluídos 238 pacientes, com idade média de 42 anos, majoritariamente do sexo masculino (68%), solteiros (46%) e economicamente ativos (66%). Cerca de 20% dos traumas foi severo, com maior prevalência de colisão de trânsito (64%). Pelo menos uma substância psicoativa foi detectada em 33 % dos pacientes, Álcool em 11,8%, cocaína em 9,2%, cannabis em 7,9%, cetamina em 0,8%, benzodiazepínicos em 4,6%, antidepressivos em 8,2% e múltiplas substâncias em 7,9%. Alcoolemia positiva foi associada significativamente ao sexo masculino e a traumas mais severos. Conclusão: a prevalência de pacientes traumatizados sob efeito de alguma substância psicoativa foi alta em nossa amostra. A identificação desses pacientes no departamento de emergência e intervenções de prevenção secundária são essenciais para diminuir a recorrência do trauma, a morbimortalidade e os custos desta doença.
Gambaran Kadar Hemoglobin dan Kadar Kreatinin pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis di RSUD Tarutung
Authors: Lumbantobing Michael Parningotan 
Published: September 2022

Gagal ginjal kronik merupakan penurunan fungsi ginjal secara progresif dan terjadi selama beberapa bulan hingga bertahun–tahun lamanya dan menimbulkan gangguan hematologi seperti anemia. Penelitian ini bertujuan untuk mengetahui gambaran kadar hemoglobin dan kadar kreatinin pasien gagal ginjal kronik yang menjalani hemodialisis. Penelitian ini telah dilakukan di RSUD Tarutung pada Januari sampai Mei tahun 2020. Metode penelitian ini yaitu penelitian deskriptif dengan desain cross sectional. Sampel diambil secara total sampling dan diperoleh 92 responden dari rekam medis. Hasil penelitian didapati laki–laki sebanyak 62 orang dan 30 orang perempuan. Berdasarkan usia termuda 18-28 tahun (4 orang), usia terbanyak 51-61 tahun (32 orang), dan usia tertua 73-83 tahun (3 orang). Kadar hemoglobin sebelum dan sesudah hemodialisis 1 kali 9,21 gr/dl menjadi 8,83 gr/dl, 2 kali 9,49 gr/dl menjadi 9,16 gr/dl, dan 3 kali 8,99 gr/dl menjadi 9,60 gr/dl. Dan kadar kreatinin sebelum dan sesudah hemodialisis 1 kali 12,68 mg/dl menjadi 13,52 mg, 2 kali 12,86 mg/dl menjadi 14,40 mg/dl, dan 3 kali 14,16 mg/dl menjadi 13,05 mg/dl. Kesimpulan penelitian ini mayoritas pasien yang menjalani hemodialsis adalah laki–laki berusia 51-61 tahun dan pasien tetap mengalami anemia setelah hemodialisis, sementara kadar kreatinin tetap tinggi walaupun telah hemodialisis.
Gambaran Tingkat Stress, Kecemasan dan Depresi Mahasiswa saat Adaptasi Tahun Kedua Pandemi COVID-19
Authors: Gaite Glarisa , Ingkiriwang Elly , Tania Elly 
Published: September 2022

Kasus COVID-19 pertama kali muncul di Indonesia pada Maret 2020. Memasuki tahun kedua pandemi Covid-19, berbagai adaptasi terhadap proses belajar di perguruan tinggi dilakukan. PDSKJI (Perhimpunan Dokter Spesialis Kedokteran Jiwa Indonesia) mencatat 1.522 penduduk Indonesia mengalami gangguan kesehatan mental akibat pandemi COVID-19 ini, tidak terkecuali para mahasiswa. Tujuan penelitian ini adalah untuk mengetahui tingkat stress, cemas dan depresi pada mahasiswa pada tahun kedua adaptasi pandemi. Penelitian deskriptif ini menggunakan metode purposive sampling, dimana mengikutsertakan 97 orang mahasiswa kedokteran angkatan Tahun 2018 di Fakultas Kedokteran sebagai responden. Penelitian ini bertujuan menentukan tingkat stres, kecemasan, dan depresi responden penelitian di tahun ke-2 pandemi. Data penelitian dikumpulkan pada Bulan Mei 2021 dengan menggunakan kuesioner DASS-21 (Depression Anxiety Stress Scales). Hasil penelitian menunjukkan bahwa 55.67% responden penelitian berada pada level stress normal, kecemasan (86,6%) dan depresi (57,73%). Studi ini juga meneliti faktor-faktor seperti jenis kelamin, usia, interaksi sosial, dan ekonomi. Responden yang mengalami kecemasan dan depresi lebih banyak ditemukan pada mahasiswa dengan status ekonomi keluarga menurun dan tidak aktif berinteraksi sosial. Peranan organisasi kemahasiswaan di kampus serta penanggulangan pandemi yang efektif diharapkan dapat mengatasi stress, cemas dan depresi pada mahasiswa saat perkuliahan online di masa pandemi.
The Effectiveness of a Training Program via E-Learning Platforms in Developing the Technological Competencies of Pre-Service Teachers
Authors: Al-Sharidah Majed Ali 
Published: September 2022

This study aims to investigate the effectiveness of a training program via e-learning platforms in developing technological teaching competencies in pre-service teachers at Prince Sattam bin Abdulaziz University. The sample comprised 67 male and female Pre-Service Teachers at the College of Education, Wadi Addawasir. In this quasi-experimental research, only one experimental group was involved. For data collection on the technological competencies of pre-service teachers, a questionnaire and an observation card were used. The results demonstrate significant differences between the pre-service teachers’ pre- and post-measurement mean scores in the cognitive and performance dimensions of technological teaching competencies when using e-learning platforms in favor of post-measurements. Furthermore, for gender and academic achievement, there were no statistically significant differences among pre-service teachers’ mean scores in the cognitive and performance dimensions of technological teaching competencies when using e-learning platforms. The study concludes with recommendations that could contribute to the success of the distance learning experience.

Received: 27 June 2022 / Accepted: 13 August 2022 / Published: 2 September 2022
SPATIAL CHANGES OF BIOCLIMATIC COLD STRESS INDICES IN THE ARCTIC ZONE OF THE RUSSIAN FEDERATION
Authors: Преминина Яна Клавдиевна , Пашкова Ксения Юрьевна 
Published: September 2022

В статье рассмотрены пространственные изменения биоклиматических индексов холодового стресса в Арктической зоне Российской Федерации.
The article examines spatial changes in bioclimatic indices of cold stress in the Arctic zone of the Russian Federation.
THE PROGRAM OF CORRECTIONAL IMPACT OF THE EFFICIENCY OF SAFETY MANAGEMENT IN THE ENTERPRISES OF THE COAL INDUSTRY
Authors: Каргина Анастасия Евгеньевна , Медовикова Евгения Александровна , Морозова Ирина Станиславовна , Гриненко Дарья Николаевна 
Published: September 2022

В статье представлена модель коррекционного воздействия эффективности управления безопасностью работ на промышленных предприятиях, включающая темы, обращенные к аспектам саморазвития и самоактуализации личностных качеств участников. Цель статьи состоит в обозначении параметров психологической безопасности личности, претерпевающих позитивные изменения в результате реализации комплекса мероприятий.
The article presents a model of the corrective impact of the efficiency of work safety management at industrial enterprises, including topics addressed to aspects of self-development and self-actualization of the personal qualities of participants. The purpose of the article is to designate the parameters of the psychological security of the individual, undergoing positive changes as a result of the implementation of a set of measures.
THE RELATIONSHIP BETWEEN THE IMPLEMENTATION OF ESG PRINCIPLES AND THE INNOVATION ACTIVITY OF COMPANIES
Authors: Сокольникова Ирина Вячеславовна 
Published: September 2022

Статья посвящена анализу влияния внедрения ESG - принципов на инновационную политику российских компаний. В работе показано, что современные условия ведения бизнеса требуют от компаний в первую очередь реализации инновационных проектов по повышения экологической безопасности производственных процессов и выпускаемой продукции, запуску социальных инноваций и совершенствованию корпоративного управления.
The article is devoted to the analysis of the impact of ESG principles implementations on the innovation policy of Russian companies. The work shows that contemporary business conditions require companies, first of all, to implement innovative projects to improve the ecological safety of production processes and products, launch social innovations and improve corporate governance.
MATHEMATICAL AND STATISTICAL SUPPORT OF STUDENT'S KNOWLEDGE ASSESSMENT DURING TESTING
Authors: Бывшев Виктор Алексеевич , Богомолов Александр Иванович 
Published: September 2022

В настоящее время педагогические тесты являются общепринятым инструментом обучения и контроля знаний студентов и используются при аттестации вузов [1]. В предлагаемой работе обсуждён формализованный подход к трансформации количества правильных ответов студента в тесте в шкалу привычных оценок [2, c. 9-10]. Подход основан на математико-статистической теории проверки гипотез [3, c.320].
Currently, pedagogical tests are a generally accepted tool for teaching and monitoring students' knowledge and are used in the certification of universities [1]. In the proposed paper, a formalized approach to the transformation of the number of correct answers of a student in a test into a scale of habitual assessments is discussed [2, p. 9-10]. The approach is based on the mathematical-statistical theory of hypothesis testing [3, p.320].
GENERATIONS OF THE FUTURE: CONSUMPTION IN THE CONDITIONS OF THE DIGITAL TRANSFORMATION OF THE ECONOMY
Authors: Петросян Анаит Ариковна 
Published: September 2022

Более 25 лет назад мир предпринял попытку подключить потребителей к цифровым ресурсам. Интернет предоставляет пользователям быстрый доступ к информации, коммерции и коммуникациям, но скорость внедрения сильно варьируется от страны к стране. Одной из причин для такого неравенства относится неравная покупательная способность потребителей и отсутствие соответствующей инфраструктуры.
More than 25 years ago, the world made an attempt to connect consumers to digital resources. The Internet provides users with quick access to information, commerce and communication, but the speed of adoption varies greatly from country to country. One of the reasons for this disparity is the unequal purchasing power of consumers and the lack of appropriate infrastructure.
ROLE OF PUBLIC ORGANIZATIONS IN SOLVING THE PROBLEMS OF OLDER PEOPLE IN THE RUSSIAN FEDERATION
Authors: Зайцева Ирина Александровна 
Published: September 2022

В статье рассматривается роль общественных организаций в решении проблем пожилых людей в Российской Федерации. Представлен анализ деятельности МОБФ «Качество жизни» по повышению качества жизни пожилых людей путем реализации социальных программы и проектов, направленных на защиту интересов и поддержание достойного уровня жизни пожилых граждан.
The article discusses the role of public and charitable organizations in solving the problems of older people in the Russian Federation. An analysis of the activities of the MOBF «Quality of Life» to improve the quality of life of older people through the implementation of social programs and projects aimed at protecting the interests and maintaining a decent standard of living of older citizens was presented.
PRESENTATION OF DIDACTIC UNITS IN GRADE 8 ALGEBRA ON DIGITAL EDUCATIONAL PLATFORMS
Authors: Попова Ксения Владимировна , Малышева Елена Николаевна 
Published: September 2022

В данной статье представлен анализ представления дидактических единиц (тем) учебников по алгебре 8 класса на популярных цифровых образовательных платформах («Российская электронная школа», «ЯКласс», «Skysmart Класс»). Используемые сегодня цифровые образовательные ресурсы находятся на различных платформах, что может негативно сказываться на образовательном процессе.This article presents an analysis of the presentation of didactic units (topics) of 8th grade algebra textbooks on popular digital educational platforms («Russian Electronic School», «Yaklass», «Skysmart Class»). The digital educational resources used today are on various platforms, which can negatively affect the educational process.
INTERTEXTUALITY IN THE CONTEXT OF THE LINGUISTIC TRADUCTOLOGY
Authors: Рыжаков Вадим Сергеевич 
Published: September 2022

В предлагаемой статье анализируется круг основных проблем, возникающих при переводе интертекстуальных включений. Автором рассмотрены базовые критерии достижения и оценки эквивалентности и адекватности перевода единиц языка, идентифицируемых как интертекстуальные включения.
The article analyzes the main problems related to translation of intertextual inclusions. The author examined the basic criteria required to attain and estimate the equivalency and the adequacy of translation of the language units, identified as intertextual inclusions.
PROSPECTS FOR THE DEVELOPMENT OF CRYPTOCURRENCIES IN THE RUSSIAN FEDERATION UNDER SANCTIONS RESTRICTIONS
Authors: Исьянов Алексей Сергеевич , Нечай Екатерина Евгеньевна 
Published: September 2022

В статье рассматриваются перспективы использования государством технологий цифровых валют, направленные на преодоления возникших сложностей в международных переводах и создания нормативно правового поля для формирования высокотехнологичной отрасли.
The article discusses the prospects for the use of digital currency technologies by the state, aimed at overcoming the difficulties encountered in international transfers and creating a regulatory framework for the formation of a high-tech industry.
TRENDS IN THE DEVELOPMENT OF CURRENCY OPERATIONS OF BANKS
Authors: Абдурахманов Артем Сергеевич , Жегалова Елена Валерьевна 
Published: September 2022

В статье рассмотрены современные проблемы осуществления валютных операций банков, мероприятия по снижению валютных рисков, определены тенденции развития валютных операций.
The article discusses the current problems of foreign exchange transactions of banks, measures to reduce currency risks, and identifies trends in the development of foreign exchange transactions
METHODOLOGICAL RECOMMENDATIONS ON THE USE OF DIGITAL EDUCATIONAL RESOURCES IN VARIOUS TYPES OF LESSONS
Authors: Попова Ксения Владимировна , Малышева Елена Николаевна 
Published: September 2022

Применяемые на уроках цифровые образовательные ресурсы должны использоваться сообразно целям и задачам урока, а также его типу. В данной статье представлены методические рекомендации по использованию цифровых образовательных ресурсов на уроках алгебра в 8 классе (УМК А.Г. Мерзляк, В.П. Полонский, М.С. Якир).
The digital educational resources used in the lessons should be used in accordance with the goals and objectives of the lesson, as well as its type. This article presents methodological recommendations on the use of digital educational resources in algebra lessons in the 8th grade (EMC A.G. Merzlyak, V.P. Polonsky, M.S. Yakir).
ANALYSIS AND EVALUATION OF THE RECURRENCE OF CYCLICAL FLUCTUATIONS IN THE RUSSIAN ECONOMY
Authors: Коновалова Мария Евгеньевна 
Published: September 2022

В статье рассмотрены ключевые положения теории циклических колебаний, показана материальные основа наиболее известных видов колебаний экономической конъюнктуры. Проанализирована рекуррентность различных циклов в экономике России, показана их взаимосвязь. В статье предложены мероприятия по нивелированию негативных последствий циклических колебаний, среди которых особое значение имеют факторы совершенствования институциональной среды.
The article discusses the key provisions of the theory of cyclic fluctuations, shows the material basis of the most well-known types of fluctuations in the economic conjuncture. The recurrence of various cycles in the Russian economy is analyzed, their interrelation is shown. The article suggests measures to neutralize the negative consequences of cyclical fluctuations, among which factors of improving the institutional environment are of particular importance.
THE INFLUENCE OF PARENTAL SETTINGS ON THE LEVEL ANXIETY OF PRESCHOOL CHILDREN
Authors: Кобазева Юлия Александровна 
Published: September 2022

Статья посвящена изучению взаимосвязи различных родительских установок и тревожности у детей четырех-семи лет. В ходе исследования у родителей тревожных детей выявлено наличие таких установок, как «чрезмерная забота, установление отношений зависимости», «чрезмерное вмешательство в мир ребенка», «уклонение от контакта с ребенком», «суровость, излишняя строгость», «исключение внесемейных влияний».
The article is devoted to the study of the relationship between different parental attitudes and anxiety in children aged four to seven years. In the course of the study, parents of anxious children revealed the presence of such attitudes as "excessive care, establishment of dependency relationships", "excessive interference in the child's world", "avoidance of contact with the child", "severity, excessive severity", "exclusion of extra-family influences".
PROSPECTS FOR THE DEVELOPMENT OF THE HOUSING MORTGAGE LENDING MARKET IN RUSSIA
Authors: Васильева Дарьяна Васильевна , Недорезова Елена Сергеевна 
Published: September 2022

Научная статья в направлении экономической науки, раскрывающая перспективы развития рынка ипотечного жилищного кредитования в России.
A scientific article in the direction of economics, revealing the prospects for the development of the mortgage housing lending market in Russia.
FORMATION OF LISTENER CULTURE IN STUDENTS WITH AUTISM SPECTRUM DISORDER IN THE PROCESS OF MUSICAL PERCEPTION
Authors: Чернявская Дарья Александровна , Дмитриев Владислав Алексеевич , Швецова Ольга Юрьевна 
Published: September 2022

В статье поднимается проблема формирования слушательской культуры у детей с расстройствами аутистического спектра. Приведены методы и приемы активизации музыкального восприятия, которые могут применяться в практической деятельности.
The article raises the problem of the formation of a listening culture in children with autism spectrum disorders. Methods and techniques for activating musical perception that can be used in practice are given.
YOUNG PEOPLE’S PROFESSIONAL ORIENTATION AS THE MAIN MECHANISM THAT PROVIDES THE PERSONNEL COMPONENT OF THE ECONOMY OF THE SAMARA REGION
Authors: Недорезова Елена Сергеевна , Фролова Александра Алексеевна 
Published: September 2022

Задачей данной статьи является определение принципов проведения профориентационной работы с молодежью на региональном уровне в контексте развития кадрового ресурса Самарского региона в период экономической нестабильности. В статье использованы методы системного подхода, аналитического сбора и обработки информации.
The purpose of this article is to determine the principles of career guidance work with young people at the regional level in the context of the development of the personnel resource of the Samara region during the period of economic instability. This article uses methods of a systematic approach, analytical collection and processing of information.