bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study
Authors: Trares Kira , Bhardwaj Megha , Perna Laura , Stocker Hannah , Petrera Agnese , Hauck Stefanie M. , Beyreuther Konrad , Brenner Hermann , Schöttker Ben 
Published: September 2022

AbstractBackgroundChronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet.MethodsThe Olink Target 96 Inflammation panel was measured in baseline serum samples (collected 07/2000–06/2002) of 1782 older adults from a German, population-based cohort study in a case-cohort design. Logistic regression models were used to assess the associations of biomarkers with all-cause dementia, Alzheimer’s disease, and vascular dementia incidence.ResultsDuring 17 years of follow-up, 504 participants were diagnosed with dementia, including 163 Alzheimer’s disease and 195 vascular dementia cases. After correction for multiple testing, 58 out of 72 tested (80.6%) biomarkers were statistically significantly associated with all-cause dementia, 22 with Alzheimer’s disease, and 33 with vascular dementia incidence. We identified four biomarker clusters, among which the strongest representatives, CX3CL1, EN-RAGE, LAP TGF-beta-1, and VEGF-A, were significantly associated with dementia endpoints independently from other inflammation-related proteins. CX3CL1 (odds ratio [95% confidence interval] per 1 standard deviation increase: 1.41 [1.24–1.60]) and EN-RAGE (1.41 [1.25–1.60]) were associated with all-cause dementia incidence, EN-RAGE (1.51 [1.25–1.83]) and LAP TGF-beta-1 (1.46 [1.21–1.76]) with Alzheimer’s disease incidence, and VEGF-A (1.43 [1.20–1.70]) with vascular dementia incidence. All named associations were stronger amongAPOEε4-negative subjects.ConclusionWith this large, population-based cohort study, we show for the first time that the majority of inflammation-related proteins measured in blood samples are associated with total dementia incidence. Future studies should concentrate not only on single biomarkers but also on the complex relationships in biomarker clusters.
Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction
Authors: Zhang Dong , Hao Wenyan , Niu Qi , Xu Dongdong , Duan Xuejiao 
Published: September 2022

Abstract
Background
In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients’ lives. However, ventilator-induced diaphragm dysfunction (VIDD) can complicate treatment by hindering weaning in critically ill patients and worsening outcomes. The goal of this study was to identify potential genes involved in the endogenous protective mechanism against VIDD.

Methods
Twelve adult male rabbits were assigned to either an MV group or a control group under the same anesthetic conditions. Immunostaining and quantitative morphometry were used to assess diaphragm atrophy, while RNA-seq was used to investigate molecular differences between the groups. Additionally, core module and hub genes were analyzed using WGCNA, and co-differentially expressed hub genes were subsequently discovered by overlapping the differentially expressed genes (DEGs) with the hub genes from WGCNA. The identified genes were validated by western blotting (WB) and quantitative real-time polymerase chain reaction (qRT–PCR).

Results
After a VIDD model was successfully built, 1276 DEGs were found between the MV and control groups. The turquoise and yellow modules were identified as the core modules, and Trim63, Fbxo32, Uchl1, Tmprss13, and Cst3 were identified as the five co-differentially expressed hub genes. After the two atrophy-related genes (Trim63 and Fbxo32) were excluded, the levels of the remaining three genes/proteins (Uchl1/UCHL1, Tmprss13/TMPRSS13, and Cst3/CST3) were found to be significantly elevated in the MV group (P < 0.05), suggesting the existence of a potential antiproteasomal, antiapoptotic, and antiautophagic mechanism against diaphragm dysfunction.

Conclusion
The current research helps to reveal a potentially important endogenous protective mechanism that could serve as a novel therapeutic target against VIDD.
Systematic review of lifestyle interventions to improve weight, physical activity and diet among people with a mental health condition
Authors: Bradley Tegan , Campbell Elizabeth , Dray Julia , Bartlem Kate , Wye Paula , Hanly Grace , Gibson Lauren , Fehily Caitlin , Bailey Jacqueline , Wynne Olivia , Colyvas Kim , Bowman Jenny 
Published: September 2022

Abstract
Background
People with a mental health condition experience an elevated risk of chronic disease and greater prevalence of health and behaviours. Lifestyle interventions aim to reduce this risk by modifying health behaviours such as physical activity and diet. Previous reviews exploring the efficacy of such interventions for this group have typically limited inclusion to individuals with severe mental illness (SMI), with a focus of impact on weight. This review assessed the efficacy of lifestyle interventions delivered in community or outpatient settings to people with any mental health condition, on weight, physical activity and diet.

Methods
Eligible studies were randomised or cluster-randomised controlled trials published between January 1999 and February 2019 aiming to improve weight, physical activity or diet, for people with any mental health condition. Two reviewers independently completed study screening, data extraction and assessment of methodological quality. Primary outcome measures were weight, physical activity and diet. Secondary outcome measures were body mass index (BMI), waist circumference, sedentary behaviour and mental health. Where possible, meta-analyses were conducted. Narrative synthesis using vote counting based on direction of effect was used where studies were not amenable to meta-analysis.

Results
Fifty-seven studies were included (49 SMI only), with 46 contributing to meta-analyses. Meta-analyses revealed significant (< 0.05) effect of interventions on mean weight loss (−1.42 kg), achieving 5% weight loss (OR 2.48), weight maintenance (−2.05 kg), physical activity (IPAQ MET minutes: 226.82) and daily vegetable serves (0.51), but not on fruit serves (0.01). Significant effects were also seen for secondary outcomes of BMI (−0.48 units) and waist circumference (−0.87cm), but not mental health (depression: SMD −0.03; anxiety: SMD −0.49; severity of psychological symptoms: SMD 0.72). Studies reporting sedentary behaviour were not able to be meta-analysed. Most trials had high risk of bias, quality of evidence for weight and physical activity were moderate, while quality of evidence for diet was low.

Conclusion
Lifestyle interventions delivered to people with a mental health condition made statistically significant improvements to weight, BMI, waist circumference, vegetable serves and physical activity. Further high-quality trials with greater consistency in measurement and reporting of outcomes are needed to better understand the impact of lifestyle interventions on physical activity, diet, sedentary behaviour and mental health and to understand impact on subgroups.

Systematic review registration
PROSPERO CRD42019137197
Congestion aware low power on chip protocols with network on chip with cloud security
Authors: Ponnan Suresh , Kumar Tikkireddi Aditya , VS Hemakumar , Natarajan Sakthieswaran , Shah Mohd Asif 
Published: September 2022

AbstractThis article is to analyze the bottleneck problems of NoC in many more applications like multi-processor communication, computer architectures, and network interface processors. This paper aims to research the advantages and disadvantages of low congestion protocols on highway environments like multiple master multiple slave interconnections. A long-term evolution and effective on-chip connectivity solution for secured, congestion aware and low power architecture is emerged for Network-on-Chip (NoC) for MCSoC. Applications running simultaneously on a different chip are often exchanged dynamically on the chip network. Of-course, in general on chip communication, resources mean that applications may interact with shared resources to influence each other's time characteristics.
Patient evaluation of a smartphone application for telehealth care of opioid use disorder
Authors: Bosse Jordon D. , Hoffman Kim , Wiest Katharina , Todd Korthuis P. , Petluri Ritwika , Pertl Kellie , Martin Stephen A. 
Published: September 2022

Abstract
Background
People with opioid use disorder (OUD) face barriers to entering and remaining in life-saving treatment (e.g., stigma, detrimental interactions with health care, and privacy concerns). Telehealth and related technology can reduce barriers to entering and staying in care. Patient feedback is critical to the development of these newer treatment approaches to ensure they are usable and do not inadvertently recreate treatment barriers.

Purpose
Evaluate the perceived usability of existing and planned features of a mobile application (app) that facilitates delivery of OUD treatment via telehealth.

Methods
People with current or prior experience with OUD treatment were eligible for the study. Participants (n = 31; 55% women) provided feedback on an interactive prototype demonstration via individual qualitative interviews and completed a quantitative survey on the app’s perceived usability. Descriptive statistics summarized the usability survey. We analyzed qualitative interview transcripts to elicit common themes.

Results
Participants were primarily white (77%) with a mean age of 42.2 years (range 22–69). Participants rated the six major features of the current app as helpful (median response 5 out of 5) and appreciated the flexibility of conducting a visit from a place of their choosing. Participants regarded the five proposed components of the app, such as daily affirmations and medication treatment-related reminders (e.g., pick up medication at pharmacy, medication schedule), as useful features with medians 5 out of 5, and reported they would recommend the app to others for OUD care. Participant qualitative interviews provided additional information on perceived usability of existing and proposed app features.

Conclusion
Our study suggests that an appealing, easy-to-use app—with tools and features that effectively support care—could circumvent existing barriers and foster sustained recovery.
Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus
Authors: Zhou Renpeng , Wang Qirui , Hou Jialin , Wang Danru , Liang Yimin 
Published: September 2022

Abstract
Background
Giant congenital melanocytic nevus (GCMN) is the benign nevomelanocytic proliferation. Mutations in NRAS have been previously detected in GCMN, but mutations in BRAF are generally lacking in the Chinese population. Mutated genes in this disease can estimate the risk of malignant transformation in GCMN. Therefore, it is worth investigating the genetic information of GCMN.

Methods
Here, we presented two cases of GCMN of the upper extremities. The clinical and histological data were analyzed. The whole exome sequencing (WES) was performed to investigate the mutational profile of peripheral venous blood (PB), normal skin (NS), small melanocytic nevus (SMN), deep penetrating and non-penetrating GCMN (dPGCMN and nPGCMN).

Results
We showed a reduction in the circumference of involved upper extremities in both patients. The clinical and histopathological data indicated the reduction of adipose tissue associated with the invasion of GCMN. The WES data revealed that MUC16, MAP3K15 and ABCA1 were novel potential candidate genes for the disease as well as biomarkers for predicting malignant transformation.

Conclusion
The MUC16, MAP3K15 and ABCA1 may serve as novel biomarkers for predicting malignant transformation and targets for the diagnoses and therapy for the GCMN.
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial
Authors: DiSilvestro Paul , Banerjee Susana , Colombo Nicoletta , Scambia Giovanni , Kim Byoung-Gie , Oaknin Ana , Friedlander Michael , Lisyanskaya Alla , Floquet Anne , Leary Alexandra , Sonke Gabe S. , Gourley Charlie , Oza Amit , González-Martín Antonio , Aghajanian Carol , Bradley William , Mathews Cara , Liu Joyce , McNamara John , Lowe Elizabeth S. , Ah-See Mei-Lin , Moore Kathleen N. ,   on behalf of the SOLO1 Investigators
Published: September 2022

PURPOSE In SOLO1/GOG 3004 (ClinicalTrials.gov identifier: NCT01844986 ), maintenance therapy with the poly(ADP-ribose) polymerase inhibitor olaparib provided a sustained progression-free survival benefit in patients with newly diagnosed advanced ovarian cancer and a BRCA1 and/or BRCA2 (BRCA) mutation. We report overall survival (OS) after a 7-year follow-up, a clinically relevant time point and the longest follow-up for any poly(ADP-ribose) polymerase inhibitor in the first-line setting. METHODS This double-blind phase III trial randomly assigned patients with newly diagnosed advanced ovarian cancer and a BRCA mutation in clinical response to platinum-based chemotherapy to maintenance olaparib (n = 260) or placebo (n = 131) for up to 2 years. A prespecified descriptive analysis of OS, a secondary end point, was conducted after a 7-year follow-up. RESULTS The median duration of treatment was 24.6 months with olaparib and 13.9 months with placebo, and the median follow-up was 88.9 and 87.4 months, respectively. The hazard ratio for OS was 0.55 (95% CI, 0.40 to 0.76; P = .0004 [ P < .0001 required to declare statistical significance]). At 7 years, 67.0% of olaparib patients versus 46.5% of placebo patients were alive, and 45.3% versus 20.6%, respectively, were alive and had not received a first subsequent treatment (Kaplan-Meier estimates). The incidence of myelodysplastic syndrome and acute myeloid leukemia remained low, and new primary malignancies remained balanced between treatment groups. CONCLUSION Results indicate a clinically meaningful, albeit not statistically significant according to prespecified criteria, improvement in OS with maintenance olaparib in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation and support the use of maintenance olaparib to achieve long-term remission in this setting; the potential for cure may also be enhanced. No new safety signals were observed during long-term follow-up.
Introduction
Authors: Asif Manan Ahmed 
Published: September 2022

Abstract
In situating the questions of how languages shape the ideas of history, history writing, and self-identification of community, the importance of colonialism is key. Allison Busch's scholarship framed an important intervention in our collective approach to the early-modern subcontinent. This article introduces a special section consisting of articles by students, colleagues, and mentors of Busch.
The Transcultural Eros of the ManchesterCāndāyana
Authors: Aitken Molly Emma , Busch Allison 
Published: September 2022

AbstractThis essay explores a single illustrated manuscript of Maulana Daud's Sufi narrative the Cāndāyana from the Rylands Library, Manchester, to help make sense of how Sufi poets and the sultanate-period painters who illustrated their verses realized the indigenous aesthetics of eros and the nāyikā.
Attempted Iconoclasm
Authors: Ollett Andrew 
Published: September 2022

Abstract
Dhanapāla's hymn to the image of Mahāvīra at Sanchore, composed in Apabhramsha around the beginning of the eleventh century, has been recognized to contain the earliest reference in an Indian language to Maḥmūd of Ghazna's raids in northwestern India in 1024, culminating in his destruction of the temple of Shiva at Somnath, in Gujarat. This hymn has been read as referring to another act of iconoclasm—or rather attempted iconoclasm, since it was ultimately unsuccessful—by Maḥmūd of Ghazna. This article shows that the attempted iconoclasm in question is not Maḥmūd's, but rather that of an earlier king. These earlier events, together with the geography of conquest and pilgrimage provided by Dhanapāla, suggest a political subtext for the hymn; namely, a veiled critique of the inability of the Cauḷukya kings of Gujarat to protect the religious landscape, and a veiled praise of Dhanapāla's friend and patron, the Paramāra king Bhōja.
Defining a Tradition
Authors: Rajpurohit Dalpat Singh 
Published: September 2022

Abstract
Allison Busch's seminal work on the classical Hindi literature of Mughal India demonstrated how the composition of works of poetic theory (ritigranths) became a defining literary enterprise of vernacular court poets in the Mughal-Rajput milieu. Though firmly based in a Sanskrit worldview, Hindi intellectuals exhibited newness in their theorization of the art of poetic craft. Engaging with Busch's work on the ritigranth genre, this article demonstrates how the poet-scholars of Rajasthan who were experts in Brajbhasha and Marwari—or Hindi and Rajasthani, respectively, as they are largely understood today—theorized and created new knowledge systems to define their four-hundred-year-old Marwari literary culture. Keeping up with the theoreticians of Brajbhasha who blended Vaishnava bhakti (devotion) with poetic theory, the Rajasthani scholars placed their work in a multilingual literary culture that was increasingly expanding as India came under the knowledge regimes of colonialism.
“Our 1789”
Authors: George Nathaniel 
Published: September 2022

AbstractWere the events of 1975–77 in Lebanon, commonly thought of today as an internecine sectarian war between Christians and Muslims, more comparable to the furies of revolution and counterrevolution? This article reframes the Lebanese National Movement's (LNM) “Transitional Program” as a revolutionary, anti-colonial, and radical republican challenge that sought to implement a new constitutional order based on popular sovereignty. Internally, it severed the link between sectarian affiliation and political representation that was the hallmark of the Lebanese regime. Externally, the program announced a commitment to popular struggle against imperially sustained settler colonialism in Palestine while calling into question the authoritarian practices of most regional regimes. Drawing from periodicals, memoirs, diplomatic sources, and interviews, this article considers the efforts of the LNM-PLO alliance to push the Transitional Program in the political sphere and on the battlefield. In turn, it demonstrates how the United States, Syria, Israel, and Lebanese counterrevolutionaries worked in concert to ensure that the sectarian regime would be preserved at the moment of its greatest challenge. Against a historiography that either dismisses the venture as predestined to fail or considers the period only within the shackles of post-defeat melancholia, it reevaluates the history of one of the most explicit emancipatory challenges to the Arab order.
Moving Past Models
Authors: Bardawil Fadi A. 
Published: September 2022

Abstract
This essay makes the case for moving away from a genre of writing about revolutions that elevates particular ones to the status of models and exemplars, which then become the touchstone of all subsequent revolutionary processes. This way of looking at emancipatory movements risks excising some from the domain of revolutionary practice for not fitting a model, and relegating others to the status of belated and derivative ones that repeat the stages of the earlier model. Instead, the author suggests moving past models to pay attention to the practices of translation that revolutionaries engage in and that inform their intellectual and political traditions. Sidelining the conceptual universe of models and centering translation enables a reckoning with difference and the emergence of newness. It is also crucial for rethinking a politics of solidarity across difference in, and for, our present.
Long-Term Outcomes of Bilateral Subthalamic Nucleus Deep Brain Stimulation for Patients With Parkinson's Disease: 10 Years and Beyond
Authors: Park Hye Ran , Im Hyung-Jun , Park Jeongbin , Yoon Byung Woo , Lim Yong Hoon , Song Eun Jin , Kim Kyung Ran , Lee Jae Meen , Park Kawngwoo , Park Kwang Hyon , Park Hyun Joo , Shin Jung-Hwan , Woo Kyung Ah , Lee Jee Young , Park Suyeon , Kim Han-Joon , Jeon Beomseok , Paek Sun Ha 
Published: September 2022

BACKGROUND:
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) represents an effective treatment for severe Parkinson's disease (PD), but little is known about the long-term benefit.

OBJECTIVE:
To investigate the survival rate and long-term outcome of DBS.

METHODS:
We investigated all 81 patients including 37 males and 44 females who underwent bilateral STN DBS from March 2005 to March 2008 at a single institution. The current survival status of the patients was investigated. Preoperative and postoperative follow-up assessments were analyzed.

RESULTS:
The mean age at the time of surgery was 62 (range 27-82) years, and the median clinical follow-up duration was 145 months. Thirty-five patients (43%) died during the follow-up period. The mean duration from DBS surgery to death was 110.46 ± 40.8 (range 0-155) months. The cumulative survival rate is as follows: 98.8 ± 1.2% (1 year), 95.1 ± 2.4% (5 years), and 79.0 ± 4.5% (10 years). Of the 81 patients, 33 (40%) were ambulatory up to more than 11 years. The Unified Parkinson's Disease Rating Scale (UPDRS) score was significantly improved until 5 years after surgery although it showed a tendency to increase again after 10 years. The patient group with both electrodes located within the STN showed a higher rate of survival and maintained ambulation.

CONCLUSION:
STN DBS is a safe and effective treatment for patients with advanced PD. This study based on the long-term follow-up of large patient populations can be used to elucidate the long-term fate of patients who underwent bilateral STN DBS for PD.
Viral species differentially influence macronutrient preferences based on honey bee genotype
Authors: Penn Hannah J. , Simone-Finstrom Michael D. , de Guzman Lilia I. , Tokarz Philip G. , Dickens Rachel 
Published: September 2022

ABSTRACT
Food quantity and macronutrients contribute to honey bee health and colony survival by mediating immune responses. We determined if this held true for bees injected with chronic bee paralysis virus (CBPV) and deformed wing virus (DWV), two common honey bee ssRNA viruses. Pollen-substitute diet and syrup consumption rates and macronutrient preferences of two Varroa-resistant stocks (Pol-Line and Russian bees) were compared to Varroa-susceptible Italian bees. Bee stocks varied in consumption, where Italian bees consumed more than Pol-Line and Russian bees. However, the protein: lipid (P:L) ratios of diet consumed by the Italian and Russian bees was greater than that of the Pol-Line bees. Treatment had different effects on consumption based on the virus injected. CBPV was positively correlated with syrup consumption, while DWV was not correlated with consumption. P:L ratios of consumed diet were significantly impacted by the interaction of bee stock and treatment, with the trends differing between CBPV and DWV. Variation in macronutrient preferences based on viral species may indicate differences in energetic costs associated with immune responses to infections impacting different systems. Further, virus species interacted with bee genotype, indicating different mechanisms of viral resistance or tolerance among honey bee genotypes.