bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoinformatics and MD-simulation data suggest that Omicron spike epitopes are more interacting to IgG via better MHC class-II recognition than Delta variant.
Authors: Sarkar Aniket , Santra Dipannita , Panja Anindya Sundar , maiti smarajit 
Published: August 2022

Abstract
Background
Recently, in Nov 2021, in South Africa, the SARS CoV-2 variant Omicron was found to be highly infectious and transmissible but with the least fatality. It occupies the nasopharynx-oropharynx and easily spreads. The epidemiological data/reports suggest that several vaccines failed to neutralize Omicron. It has a large number of spike mutations and the RNA/protein vaccines were developed from its predecessors that may justify its escape in most neutralization reactions. It’s lower immuno-suppression/cytokine-storming/inflammatory-response effects need explorations.
Objectives
In the current study, we attempted to delineate the comparative interaction of different variants’ spikes with IgG and a few HLA-typing of MHC-II.
Methods
All SARS-CoV-2 spike-proteins/human-IgG/MHC-II were obtained from the NCBI/ PDB/GISAID database. Initial 3D-structures of the unavailable proteins were constructed by Homology-Modeling (Swissmodel-Expasy) and optimized (PROCHECK). Molecular-docking of spike-IgG/spike-MHC-II was performed (HADDOCK2.4/HawkDock) with active-residue screening (CPORT). Antigenicity of epitopes was determined (Vaxigen v2.0-server) and epitope-model prepared (PEP-FOLD3-server). The binding-affinity/biological-interfaces/visualize were performed (PRODIGY-PyMOL2). We also examined Molecular-Dynamic-Simulation (myPresto verson-5) of MHC-II with different epitopes and antibody IgG with different variants. The MD-simulation was run with 9000-cycles after 300k-heating/1-atm pressure adjustment for the system-equilibration. Finally, 1000ps production was run.
Results
Surface-area with interactomes, H-bonding and polar/non-polar bonding were the highest in Omicron spike-IgG interaction. Unlike other variants, both the L and H chains of the IgG interact with the N-terminal and C-terminal RBD of the S1-portion and partially bind to S2. In other cases, binding was observed in either NTD or CTD with a lesser number of bonding-interactomes, especially in Delta spike-Ab interaction. In the case of MHC class-II, the highest binding affinity/surface was noticed by omicron and least by the Delta variant. Better binding to the IgG and MHC molecules explains its lesser ability to immune invasion.
Hydrophobic Fluorescent Molecules in Multiple Organ Failure: a preliminary report.
Authors: Russo Luigi 
Published: August 2022

Abstract
Despite technological advances the mortality of Multiple Organ Failure MOF (or MODS) remains high. Liver is the main excretory organ for protein-bound toxins which accumulate in plasma of patients with hepatic failure. Hydrophobic molecules are present in plasma of patients with several toxic syndromes. Fluorescence is a characteristic of many aromatic compounds. Hydrophobic Fluorescent Molecules (HFM) in plasma have been studied in patients with MOF and hyperbilirubinemia. Heparinized venous plasma from 9 patients with MOF in post-operatory time (after cardiac surgery) was analyzed. All patients presented hyperbilirubinemia. One millilitre of plasma was extracted with 6 ml. of diethyl ether. Fluorescence of the ether fraction was determined with a digital filter fluorometer (excitation 300-400 nm. Emission >400 nm). Results were expressed in Fluorescence Arbitrary Units (A.U.). Control plasma were obtained from patients with chronic cardiac diseases; they had values mean 15 AU± 4,3 A.U. (range 11-21) of hydrophobic fluorescence. The mean Hydrophobic fluorescence of the MOF patients was 218.4 ± 276.3 A.U. (range 37-900). Data were highly significant (P<0.001).This preliminary study has shown that extremely high values of HFM are present in patients with hepatic failure and MOF. Hydrophobic molecules present a high inherent toxicity due to their insertion in the lipid bilayer of cell membranes and may be a determinant factor for the mortality of patients with MOF. The presence of specific HFM may be evaluated as a marker for prognostic purposes.
Effects of real-time remote cardiac rehabilitation on health and disability-related outcomes: a quasi-randomized controlled trial
Authors: Fukuta Yoshitatsu , Arizono Shinichi , Tanaka Shinichiro , Kawaguchi Tomonori , Tsugita Natsumi , Fuseya Takahiro , Magata Junichi , Tawara Yuichi , Segawa Tomonori 
Published: August 2022

AbstractBackground:The impact of real-time remote cardiac rehabilitation (CR) on health and disability-related outcomes and its correlation with physical function are unknown. We compared the effectiveness of real-time remote CR to that of hospital-based CR on the physical function improvement as well as physical functions of improvement (Δ) to clarify the relationship to health and disability for baseline.Methods:Patients with cardiovascular disease (CVD) were enrolled (n=38) in this quasi-randomized controlled trial and underwent 4 weeks of hospital-based CR, followed by 12 weeks of remote or hospital-based CR, based on quasi-randomized allocation. Patients were assessed at baseline and after 12 weeks of remote or hospital-based CR using the shortened version of the World Health Organization (WHO) Quality of Life scale (WHOQOL-BREF) for subjective satisfaction, WHO Disability Assessment Schedule (WHODAS2.0-J) for objective performance, and cardiopulmonary exercise test for physical function and peak oxygen uptake (peak VO2). The trends in measured variables from baseline to the post-CR stage were analyzed.Results:Sixteen patients (mean age, 72.2±10.4 years) completed remote CR, and 15 patients (mean age, 77.3±4.8 years) completed hospital-based CR. The post-CR physical function differed significantly between groups (ΔpeakVO2, 2.8±3.0 versus 0.84±1.8 mL·min-1·kg-1; p<0.05). The differences in post-CR changes in the WHOQOL-BREF score between the groups were insignificant. The post-CR change in the WHODAS2.0-J score was significantly lower in the remote CR group than in the hospital-based CR group (ΔWHODAS2.0-J score, –8.56±14.2 versus 2.14±7.6; p<0.01). Forward multiple stepwise regression analysis using data from remote CR showed that the baseline social interaction level (WHODAS2.0-J) was a significant independent contributor to ΔpeakVO2(remote CR r2=0.65, p<0.001; hospital-based CR r2=0.38, p<0.05; respectively). For hospital-based CR, baseline mobility (WHODAS2.0-J) was a significant independent contributor to ΔpeakVO2(r2=0.38, p<0.05).Conclusions:Remote CR significantly improved physical function and objective performance in patients with CVD. Remote CR could be an effective treatment for stable patients who are unable to visit hospitals.Trial Registration: This interventional trial was registered in the UMIN-CTR registry (trial title: Development of remote program for cardiac rehabilitation using wearable electrocardiograph; trial ID: UMIN000041746; trial URL: https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000046564; registration date: 2020/09/09).
Four-Year Report on Renal Outcomes Following Elective Withdrawal of Long-Term RAAS Blockade in a Cohort of Patients with Otherwise Inexplicable New-Onset and Progressive Acute Kidney Injury
Authors: Amechi Macaulay 
Published: August 2022

Abstract
Background:
RAAS blockade is renoprotective for both diabetic and non-diabetic CKD. There have been discordant reports on renal and cardiovascular outcomes following RAAS blockade discontinuation in advanced CKD. To the contrary, a few prospective cohort studies have demonstrated reversal of otherwise inexplicable AKI in patients after discontinuation of RAAS blockade. This is a 4-year report of such a cohort.
Methods:
Prospective Cohort Analysis, enrolled between February 2018 – May 2021. Kidney function was monitored after elective withdrawal of long-term RAAS blockade in CKD patients presenting with new-onset otherwise inexplicable progressive AKI as defined by a > 25% increase in baseline serum creatinine.
Results:
By February 2022, 12 patients had died, and 8 patients were on hemodialysis for ESRD. The remaining 51 patients, with a baseline serum creatinine of 1.30 ± 0.42 (0.66–2.70) mg/dL, have been followed up for 706 (40-1478) days. Peak serum creatinine at study entry was 2.17 ± 1.06 (1.1–8.3) mg/dL, n = 51, P < 0.0001, t = 6.4872, df = 135. Serum creatinine, 48 months later, was 1.58 ± 0.54 (0.84–3.3) mg/dL, n = 50, p < 0.0001, t = 5.1805, df = 119. Death in 7 of 8 (87.5%) patients were from non-renal causes; most deaths occurred despite improved kidney function.
Conclusion:
Elective withdrawal of long-term RAAS blockade in CKD patients with new-onset progressive yet otherwise inexplicable AKI results in significant sustainable renal salvage. Such self-selected patients generally exhibit improved renal outcomes without increased mortality. This is consistent with late-onset renal failure from angiotensin blockade (LORFFAB), first described in 2005 from the Mayo Clinic Health System in Northwestern Wisconsin.
Exploring Polyvagal's Theory in Immigrants' Experiences of the COVID-19 Pandemic
Authors: Alama Ernie Z. , MacCallum Donald , Celis Sherrisa 
Published: August 2022

Abstract
The College of Researchers for Development Society (CORDS) explores the experiences and effects of COVID-19 on Canadians. A section of the study explores and examines the COVID-19 experiences of immigrants in Alberta. The study examined Albertans' response to the coronavirus crisis – experiences that may invoke the social dimensions around safety and danger theory (Polyvagal's Theory): flight, freeze, or fight or engage when faced with a life-threatening and challenging situation. It is anchored in the assumption that when a social barometer of engagement is triggered, citizens become proactive in managing obstacles, thus enabling them to be resilient and overcome challenges like the COVID-19 pandemic. Specific interests in this paper focused on the pandemic experiences of the immigrant participants during the coronavirus pandemic -- thematic findings around coping range from fight to positive engagement and resilient response.
Income inequality, carbon emissions and green development efficiency
Authors: Yong-chun SUN 
Published: August 2022

Abstract
Income inequality not only affects social well-being, health, and promotes carbon emissions, but also affects China's basic national policy for green development.Therefore, based on the panel data of 205 cities in China from 2010 to 2020, a panel model with partial linear functional coefficient is used to analyze and test the relationship between income inequality, carbon emissions and green development efficiency under different regional economic development levels.The research results show that: in the early stage, when the urban economic development is at a low level, income inequality has an inhibitory effect on carbon emissions and does not contribute to the efficiency of green development; Some green development efficiency has a promoting effect, but with the evolution of time, the impact of income inequality on carbon emissions and green development efficiency is gradually insignificant in areas with low and high levels of urban economic development.
Existence of positive solutions for Lidstone boundary value problems on time scales
Authors: Çetin Erbil , Topal Fatma Serap , Agarwal Ravi P. 
Published: August 2022

Abstract
Let T ⊆ R be a time scale. The purpose of this paper is to present sufficient conditions for the existence of multiple positive solutions of the following Lidstone boundary value problem on time scales (−1)nyΔ(2n)(t) = f(t, y(t)), t ∈ [a, b]T, yΔ(2i)(a) = yΔ(2i)(σ2n−2i(b)) = 0 i = 0, 1, ..., n − 1. Existence of multiple positive solutions are established using fixed point methods. At the end some examples are also given to illustrative our results.Mathematics Subject Classification 34N05;34K10; 39A10; 39A99
Supporting self-regulated learning with learning analytics interventions – a systematic literature review
Authors: Heikkinen Sami , Saqr Mohammed , Malmberg Jonna , Tedre Matti 
Published: August 2022

Abstract

During the past years scholars have shown an increasing interest in supporting students' self-regulated learning (SRL). Learning analytics (LA) can be applied in various ways to identify a learner’s current state of self-regulation and support SRL processes. It is important to examine how LA has been used to identify the need for support in different phases of SRL cycle, which channels are used to mediate the intervention and how efficient and impactful the intervention is. This will help the learners to achieve the anticipated learning outcomes. The systematic literature review followed PRISMA 2020 statement to examine studies that applied LA interventions to enhance SRL. The search terms used for this research identified 753 papers in May 2021. Of these, 56 studies included the elements of LA, SRL, and intervention. The reviewed studies contained various LA interventions aimed at supporting SRL, but only 46% of them revealed a positive impact of an intervention on learning. Furthermore, only four studies reported positive effects for SRL and covered all three SRL phases (planning, performance, and reflection). Based on the findings of this literature review, the key recommendation is for all phases of SRL to be considered when planning interventions to support learning. In addition, more comparative research on this topic is needed to identify the most effective interventions and to provide further evidence on the effectiveness of interventions supporting SRL.
Are premature infants with Spontaneous Intestinal Perforation sicker than others?
Authors: Eisenstadt Michal , Eisen Irit Schushan , Leibovitch Leah , Maayan-Metzger Ayala , Gavri Ayelet , Strauss Tzipi 
Published: August 2022

Abstract
Spontaneous intestinal perforation (SIP) is a focal gastrointestinal complication which is diagnosed in up to 5% of the very low birth weight infants. Purpose - This retrospective case control study was designed to investigate perinatal and neonatal risk factors for SIP in premature infants who developed a SIP over a 13 years period in a single NICU. Methods - A total of 40 very low birth weight infants were include in this study. Results demonstrated that infants who developed SIP were more likely to have been born via cesarean section (80% compared to 45%, p = 0.048). They were also more likely to have been fed later (average day after delivery 3 compared to 2, p = 0.039), and were more likely to have received blood transfusions prior to SIP [OR = 7.7 (95%CI = 1.084–55.049), P = 0.041]. Infants with SIP were more likely to have received non-invasive respiratory support [OR = 0.105 (95%CI = 0.015–0.755) p = 0.025]. Conclusions - These characteristics may imply that these infants are merely sicker and hence more prone to suffer from SIP.
Species diversity analysis of commercial Mantidis Ootheca samples contaminated by store pests based on DNA metabarcoding
Authors: Xu Liuwei , Zhang Xiaoying , Guo Hua , Yang Xia , Xing Zhimei , Yang Wenzhi , Zhang Jian , Tian Xiaoxuan 
Published: August 2022

Abstract
Mantidis Ootheca (Sangpiaoxiao) is a typical multi-origin Chinese medicinal material. The Chinese Pharmacopoeia stipulates that the Mantidis Ootheca originates from Tenodera sinensis, Statilia maculate, and Hierodula patellifera. However, Mantidis Ootheca mainly relies on field collection, which leads to confusion of its actual origin in the market. As the clinical use of Mantidis Ootheca with unknown origin will pose potential risks to drug safety, it is necessary to survey the commercially available Mantidis Ootheca origin species. However, as the egg case of Mantis, the morphological characters of Mantidis Ootheca are limited and usually cannot serve as accurate identification tool. DNA barcoding, which is widely used in taxonomic studies of animals, is severely affected by the impact of storage pests and DNA degradation. Thus, this study aimed to analyze the origin diversity of 4,580 Mantidis Ootheca individuals contaminated by common store pests collected in the market using mini-barcode combined with DNA metabarcoding, and to provide a basis for quality control of Mantidis Ootheca. 37 Mantis ASVs and 9 Mantis MOTUs were identified through species delimitation, and the high level intraspecific diversity was depicted as haplotype network plot. Besides Tenodera sinensis and Hierodula patellifera as genuine sources defined in the Chinese Pharmacopoeia, Tenodera angustipennis was also the origin species of these Mantidis Ootheca samples.
Type I Congenital Colonic Pouch Resection With Terminal Ileostomy in a 43-year-old Woman. Case Report
Authors: Jorge Chucuán-García , José Ochoa-Martínez , Ricardo Espinoza-Pérez , Miguel Silva-García , Torres-Salazar Quitzia Libertad 
Published: August 2022

Abstract
INTRODUCTION: Congenital colonic pouch syndrome is an extremely rare condition, particularly in Western countries. In this condition, the colon is replaced with a partially or completely abnormal pouch, connected to the genitourinary tract by a fistula or may end in a blind pouch. As it is a congenital condition, the cases reported are found in the neonatal population, so its detection in adulthood is extremely rare. CASE PRESENTATION: We present the case of a 43-year-old female, who was admitted to the general surgery service with suspected fistulizing CROHN's disease. She attended with a two-month clinical picture, presenting a painful ulcer in the left perianal and gluteal region, accompanied by discharge of purulent material and feces through the vaginal introitus. Laboratory tests (CAT, colonoscopy and MRI) did not present conclusive information. An exploratory laparotomy was performed, finding a congenital type I colonic pouch, so it was resected, and a terminal ileostomy was performed. CONCLUSIONS: The present case aimed to report our experience with a pathology that has not been reported in this particular age group in our country. Imaging studies before surgery were unable to diagnose the pathology, so the exploratory laparotomy was decisive for the treatment.LEVEL OF EVIDENCE: I
Highly efficient removal of hexavalent chromium by magnetic Fe-C composite from reed straw and electric furnace dust waste
Authors: Wang Fu-ping , Zeng Ya-Nan , Wang Yi-Tong , Li Jun-Guo , Zhang Xi , Ji Ai-Min , Kang Le-Le , Ji Rui , Yu Qing , Gao Di , Wang Xiao-Man , Fang Zhen 
Published: August 2022

Abstract
Reed straw and electric furnace dust (EFD) waste were used to prepare magnetic Fe-C composite (EFD&C) by co-precipitation and high-temperature activation method to remove Cr(VI) from water. The magnetic EFD&C owned a large specific surface (536.61 m2/g) and a porous structure (micropores and mesopores), and had an efficient removal capacity for Cr(VI). Under conditions of pH (2), the addition amount of EFD&C (1 g/L), the adsorption time (760 min), and the temperature (45 oC), the maximum adsorption capacity reached 111.94 mg/g. The adsorption mechanism mainly attributed to chemical adsorption (redox), Cr(VI) reduced to Cr(III) by Fe(II) and Fe(0) (from Fe3O4 and Fe components in EFD) and surface functional groups of -OH, C = C, C-C and O-C = O (from biochar), and secondary attributed to physical adsorption, Cr(VI) and Cr(III) (from reduced Cr(VI)) adsorbed into the porous structure of EFD&C. This study provided guidance for the recycling of iron-containing metallurgical solid and biomass waste.
Performance, carcass quality, and intestinal biometry of European quail fed on kelp meal (Sargassum sp)
Authors: de Oliveira Airton Gonçalves , Furtado Dermeval Araújo , Ribeiro Neila Lidiany , Marques Jordânio Inácio , Mascarenhas Nágela Maria Henrique , Leite Patrício Gomes , de Morais Fabiana Terezinha Leal , Rodrigues Raimundo Calixto Martins , de Brito Alícia Nayana dos Santos Lima , Lima Vitória Régia do Nascimento 
Published: August 2022

AbstractThis work aims to evaluate, at different stages, the productive performance, carcass quality, and intestinal biometry of European quails (Coturnix coturnix Coturnix), consuming diets with increasing levels of seaweed bran (Sargassum sp). A total of 240 European quail chicks (Coturnix coturnix Coturnix) were distributed in a completely randomized design, with four levels of bran inclusion (0.0, 2.5, 5.0, and 7.5%), 6 replications with 10 birds in each experimental plot. In the period from 1 to 21 days, the feed intake of the control group was higher, with lower water consumption. In the period from 22 to 42 days, feed and water consumption increased with the inclusion of seaweed, but with a reduction in weight gain. In the total period, water consumption was higher at the level of 2.5 and 7.5%, with lower consumption in the control group, with a small reduction in slaughter and carcass weight with the inclusion of bran. There was no difference (P > 0.05) in carcass quality and intestinal biometry. We recommended the inclusion of up to 7.5% of sargassum meal in the diet of European quails at all stages, without compromising its productive performance, carcass quality, and intestinal biometry.
Race and gender income inequality in the USA: black women vs. white men
Authors: Kitov Ivan 
Published: August 2022

Abstract
Income inequality between different races in the U.S. is especially large. This difference is even larger when gender is involved. In a complementary study, we have developed a dynamic microeconomic model accurately describing the evolution of male and female incomes since 1930. Here, we extend our analysis and model the disparity between the black and white populations in the U.S., separately for males and females. Unfortunately, income microdata provided by the U.S. Census Bureau for other races and ethnic groups is not time compatible or too short for modelling purposes. We are forced to constrain our analysis to the black and white population, but all principal results can be extrapolated to other races and ethnicities. Our analysis shows that black females and white males are two poles of the overall income inequality. The prediction of income distribution for two extreme cases with one model is the main challenge of this study. The model also predicts the time evolution for any gender/race combination. The income disparity is best cured by fast economic growth.
A comparative study on the influence of α-centroids over Κ-means algorithm and its variants in DT-RMI segmentation
Authors: Campos Alan Santos , Gregorio Ronaldo Malheiros , Cruz Marcelo Dib , Alves Charlan Dellon da Silva 
Published: August 2022

Abstract
The diffusion tensor magnetic resonance imaging (DT-MRI) is a non-invasive and effective technique that ables us to study the micro-structural integrity of white matter of fibers and detecting tumors or anomalies in living tissues. Image segmentation in DT-RMI is used to identify and separate a tissue in different regions which preserve similar properties. \(K\) -means and deep learning algorithms can be applied for this purpose, being the second class the most used currently. Despite actually deep learning algorithms are the most frequently approach in image segmentation, $K$-means algorithm performed an important role in a recent past, carrying implicitly lots of sophisticated mathematical results. Originally, $K$-means algorithm was proposed to cluster a dataset in subsets with similar characteristics. Our interesting consists in empirically analyzing this technique and their variants under both Euclidean and Riemannian setting when applied to image segmentation in DT-MRI. Pixels in the bidimensional case and voxels in the tridimensional one can be respectively represented by 2-by-2 and 3-by-3 symmetric positive definite matrices (SPD) in DT-RMI. Since the set of \(n\) -by-$n$ SPD matrices can be seen as both a non-pointed convex cone in the vector space of $n$-by-$n$ symmetric matrices as well as a Hadamard manifold, centroids are well-posed in both sense, for any positive integer $n$. Thus, we developed a comparative study on the influence of centroids under Euclidean and Riemannian settings on the image segmentation by using the $K$-means algorithm and its variants.