bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leadership for inclusiveness
Authors: Rana Bandana , Lipovina Tara , Carrasco Gómez Mónica , Fragoso Lugo Perla O. 
Published: July 2022

Scaling the summit for women’s rights: From local to global and global to local (p.21)
Bandana RanaFinding your voice and identity for many women in South Asia, including Nepal, is like climbing Mt. Everest, the highest peak in the world—not an easy task with deeply embedded patriarchal values and gender norms. Violence against women, particularly domestic violence, is the biggest deterrent to women’s advancement and development. However, with support from a vibrant women’s movement and civil society activism, scaling this mountainous hurdle can be possible. This article examines both the challenges that women in Nepal face and the progress that women’s rights groups have achieved in promoting gender equality in that country. Through both personal and systemic reflections, world-renown women’s rights activist Bandana Rana presents her journey for gender equality from the local to the global and back.Tradition, development, and gender equality: Addressing the incoherences through collective action (p.32)
Tara LipovinaThis article addresses gender coherence for development, defined as transformative development that addresses systemic power differences that discriminate against women. Following the contribution from Bandana Rana, this scientific article reflects on challenges that women face in Nepal, with specific discussion of patriarchal traditions. However, the analysis notes that the development does not necessarily positively effect gender equality. Regional policies, such as the European Union’s neighborhood policies in the Western Balkans (specifically in Montenegro), and the Association of Southeast Asian Nation’s economic policies often undermine the gender equality initiatives from these regions. The article identifies collective action and norm ownership as important bases for achieving transformative development that promotes gender equality.Mujeres indígenas, desarrollo y derecho a una vida libre de violencia (p.40)
Mónica Carrasco Gómez y Perla O. Fragoso LugoEn este artículo se argumenta la relevancia de la participación directa de las mujeres indígenas en la planeación, modelación, ejecución y evaluación de las políticas públicas dirigidas a ellas como una población diversa, con agendas comunes a las de las mujeres mestizas, pero también con necesidades, problemáticas y propuestas distintas e incluso diferenciadas según su propio grupo cultural. Para ello nos centramos en el abordaje de los programas gubernamentales y la literatura producida en torno al desarrollo social y al combate a la violencia de género contra las mujeres en el estado de Chiapas, la entidad con el mayor número de habitantes hablantes de una lengua indígena en México.
Caracterización clínica del dengue con signos de alarma y grave, en hospitales de Guayaquil
Authors: Cotto Jhony Joe , Ronceros Medrano Sergio Gerardo , Gómez García Mauricio Dionicio , Roby Arias Aurora Jazmín , Ordoñez Zavala Judith Mariuxi 
Published: July 2022

Introducción. El dengue es una infección vírica transmitida por mosquitos cuya infección va desde síntomas leves que en ocasiones evolucionan hasta un cuadro clínico llamado dengue grave. Objetivo. Caracterizar clínicamente los casos con diagnóstico de dengue con signos de alarma y dengue grave entre las semanas epidemiológicas 19 al 26 del 2014 ingresados en el Hospital de Niños Francisco de Icaza Bustamante y en adultos del hospital de Infectología de la ciudad de Guayaquil. Metodología. No experimental de tipo descriptivo, comparativo, de corte transversal; donde se comparan sus características clínicas, antecedentes y valores en pruebas hemáticas. Resultados. La fiebre re registró en el total de los pacientes, que se acompañan en los niños con nausea o vómito, dolor abdominal, artralgias, mialgias, cefaleas, entre otros, con variedad sintomática, mientras que en los adultos concuerda con la definición de casos. En las pruebas de laboratorio se detectaron casos con hemoconcentración y plaquetopenia mayormente en adultos; TGO y TGP elevadas por encima del 70 % de los casos; presencia de IgM en aproximadamente 1 de cada 2 en niños y adultos al momento de su ingreso, con anticuerpos IgG en 2 de cada 3 niños que revela una previa exposición al dengue. Conclusiones. Mayor afectación en los niños con variedad sintomática, entre 3 a 7 días de evolución, acompañados de hemoconcentración y plaquetopenia; así como, leucopenia, linfocitosis, neutropenia y las enzimas hepáticas elevadas en gran número de casos. Las pruebas serológicas específicas para dengue demuestran la infección reciente y antecedentes de infección pasada.
SUMBANGAN PENDAPATAN RUMAH TANGGA TANI DESA SARIMULYO, KECAMATAN NGAWEN, KABUPATEN BLORA
Authors: Ayu Putri Merry Anisya  
Published: July 2022

Strategi pembangunan perlu lebih dipusatkan pada peningkatan pendapatan. Struktur dan besarnya pendapatan dari sektor pertanian berasal dari usahatani atau ternak dan buruh tani, sedangkan dari sektor non pertanian berasal dari usaha non pertanian. Untuk melihat besarnta pendapatan rumah tangga tani maka dilihat dari usahatani yang dapat berkontribusi bagi pendapatan rumah tangga, dan apabila terus dapat dimanfaatkan secara optimal dengan memanfaatkan untuk proses pertanian secara kompleks, maka pengembangan usahatani lahan sawah dapat manjadi salah satu sumbangan pendapatan terhadap rumah tangga petani. Penelitian ini dilaksanakan di Kecamatan Ngawen. Sampel yang diambil yaitu rumah tangga tani yang berusahatani sebanyak 74 responden. Pengambilan sampelnya dilakukan dengan cara census. Membandingkan pendapatan yang berasal dari usahatani dengan total pendapatan rumah tangga tani. Sumbangan pendapatan yang diperoleh usahatani sebesar 64,06% terhadap pendapatan total rumah tangga petani Desa Sarimulyo dan tergolong dalam kategori sumbangan pendapatan besar. Hal ini karena masyarakat tani Desa Sarimulyo mata pencaharian utama bekerja sebagai petani padi, cabai, jagung, dll.. Upaya untuk meningkatkan sumbangan pendapatan rumah tangga tani perlu meningkatkan pendapatan dengan menambah keragaman tanaman yang memiliki nilai jual tinggi dan menciptakan inovasi teknologi pertanian.
Pengembangan Sistem Pengadaan dan Monitoring Aset Pada Kantor Desa Bajarum Berbasis Web Menggunakan Metode PIECES
Authors: Erlangga Dody , Minarni Minarni 
Published: July 2022

Undang-undang Desa telah menetapkan bahwa Desa memiliki kekuasaan dan asal dana yang memadai untuk mampu mengendalikan potensi yang dikuasainya fungsi memajukan ekonomi dan kesejahteraan masyarakatnya. Melalui pengadaan barang dan jasa oleh Pemerintah Desa yang efisien, efektif dan transparan sangat membantu terwujudnya kesejahteraan masyarakat desa begitu halnya yang terjadi pada Kantor Desa Bajarum. Kantor desa bajarum telah mengikuti pedoman kemendagri tentang pengadaan barang dan jasa desa dalam proses operasional pengadaan barang dan jasanya. Namun dalam impelementasinya, kinerja bagian kasi kesra masih sangat lambat dikarenakan proses pengadaan barang dan jasa hingga monitoring aset desa tersebut masih berupa inputan manual tanpa otomatisasi. Proses verifikasi data juga dilakukan dengan mengecek satu per satu sehingga kurang efisien. Selain itu dengan inputan data yang manual menyebabkan rentan terjadinya kasus atau kecurangan berupa korupsi aset desa dengan mengubah, modifikasi data sehingga fakta dokumentasi atau laporan berbeda dengan fakta dilapangan. Dengan memanfaatkan metode PIECES (Performance, Information, Economic, Control, Efficiency, Services), maka permasalahan tersebut dapat diatasi dengan mengembangkan Sistem Informasi untuk pengadaan dan monitoring aset desa. Pengembangan Sistem dilakukan dengan metode Waterfall. Perancangan Sistem memanfaatkan UML (Unified Modelling Language). Sistem ini berbasis web dibangun dengan bahasa pemrograman PHP dan database MySQL. Metode pengujian sistem menggunakan Blackbox. Sistem ini sudah mampu berjalan dan di implementasikan pada Kantor Desa Bajarum secara optimal.
Pengaruh ukuran perusahaan, capital intensity dan sales growth terhadap penghindaran pajak
Authors: Pravitasari Helga Ayu , Khoiriawati Novi 
Published: July 2022

This study aims to examine the effect of firm size, capital intensity and sales growth on tax avoidance in mining companies listed on the Indonesia Stock Exchange in 2016-2020. This research is a quantitative research that uses the associative type with a secondary method in the form of data on the annual financial statements of mining companies with sampling through www.idx.co.id . The sampling technique used purposive sampling method, so that obtained a sample of 132 data. This research is multiple linear regression analysis using SPSS. The result show that the first hypothesis is that firm size has no effect in tax avoidance. The second hypothesis is that capital intensity has no effect in tax avoidance. The third hypothesis is that sales growth has an effect on tax avoidance. Then, simultaneously firm size capital intensity and sales growth have on effect on tax avoidance in mining companies listed on the Indonesia Stock Exchange in 2016-2020.
English Students’ Difficulties in Understanding Listening Section of the TOEFL Test
Authors: Aprino Dandika , Elfrida Elfrida , Lubis Azhar Aziz 
Published: July 2022

The objective of this reseach is to find out the difficulties and the dominant factor that faced by the English students in understanding the listening section of the toefl test. This research used descriptive quantitative method. 18 students as the total population and 18 students become a sample of this research. The instrument of the reasearch was questionnaire adopted from Hamouda in Raini (2019). The questionnaire consist of 27 statements and devided into 7 tables. The result of this research shown that the highest percentage by using mean is in physical setting (50%) and the dominant factor is in physical setting (50%) where the problem that were the difficulty to concentrate with noises around and unclear sounds from poor quality-CD player are the biggest difficulties to the English students UNIB. It could be concluded that the content of listening test and physical setting become the highest difficulties and the dominant factor that faced by English Students UNIB. It was recommended for the English lecturer should pay more intention towards to listening material and find more suitable method or technique in teaching listening course and students should find another option to cover the listening skill.
Riscos ocupacionais dos profissionais de enfermagem hospitalar: perfil sócio demográfico e laboral
Authors: Farias Jucirema Rodrigues , Chermont Aurimery Gomes , Savino Neto Silvestre , Mauro Maria Yvone Chaves , Frazão Andrea das Graças Ferreira , Almeida Candida do Socorro Conte de , Silva Junior Paulo Cesar Beckman da , Farias Jucenira Rodrigues 
Published: July 2022

Objetivo: traçar o perfil sociodemográfico e laboral dos profissionais de enfermagem. Método: estudo com abordagem quantitativa, exploratória e descritiva. Realizado em um Hospital de Clínicas Público e de Ensino. Foram entrevistados 60 profissionais de enfermagem sendo aplicado um questionário sociodemográfico laboral. Os dados foram coletados nos meses de outubro, novembro e dezembro de 2021, foram criados gráficos e tabelas, utilizado o teste G de independência e o teste qui-quadrado, ambos com valor de significância para p <0,05, do programa BioEstat versão 5.0. Resultados:da análise houve predominância : sendo 81,7% profissionais do sexo feminino, faixa etária entre 30 a 49 anos, apresentou maior proporção (73,3%), nível superior completo 33,3%, sendo 80%provedor principal da família ,cargo de técnico de enfermagem predominante (71,4%) , 58.3% tem carga horária semanal de 30-60h.Conclusão: necessidade do desenvolvimento de políticas públicas de saúde do trabalhador locais que visem melhorias ao profissional de enfermagem com atenção a força de trabalho feminina.
Design and Synthesis of 1-O- and 6′-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors
Authors: Tseng Kuei-Yao , Tzeng Zheng-Hao , Cheng Ting-Jen Rachel , Liang Pi-Hui , Hung Shang-Cheng 
Published: July 2022

The extracellular human endo-6-O-sulfatases (Sulf-1 and Sulf-2) are responsible for the endolytic cleavage of the 6-sulfate groups from the internal D-glucosamine residues in the highly sulfated subdomains of heparan sulfate proteoglycans. A trisaccharide sulfate, IdoA2OS-GlcNS6S-IdoA2OS, was identified as the minimal size of substrate for Sulf-1. In order to study the complex structure with Sulf-1 for developing potential drugs, two trisaccharide analogs, IdoA2OS-GlcNS6OSO2NH2-IdoA2OS-OMe and IdoA2OS-GlcNS6NS-IdoA2OS-OMe, were rationally designed and synthesized as the Sulf-1 inhibitors with IC50 values at 0.27 and 4.6 μM, respectively.
Long-Term Clinical Outcomes After Percutaneous Coronary Intervention With Drug-Coated Balloon-Only Strategy in de novo Lesions of Large Coronary Arteries
Authors: Hu Feng-Wang , Chang Shang , Li Qian , Zhu Yong-Xiang , Wang Xin-Yu , Cheng You-Wei , Zhou Qi-Hua , Liu Bing , Iqbal Javaid , Tang Xiao-Xia , Zhang Yao-Jun 
Published: July 2022

Background and ObjectivesUse of drug-coated balloon (DCB)-only strategy for revascularization of native large coronary artery lesions is on the rise. The long-term efficacy of this approach for bifurcation and non-bifurcation lesions remains unknown. We aim to assess the long-term clinical outcomes of DCB-only strategy for the treatment of de novo bifurcation and non-bifurcation lesions in large coronary arteries.MethodsThis multicenter, prospective, observational study enrolled 119 patients with de novo coronary lesions in vessels ≥2.75 mm. The primary end point was the rate of clinically driven target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization (TLR). Patients were followed up for a median of 2 years.ResultsOf 119 patients with 138 lesions, 66 patients (75 lesions) had bifurcation and 53 patients (63 lesions) had non-bifurcation lesions. Average reference vessel diameter was 3.1 ± 0.3 mm, and there was no difference in bifurcation and non-bifurcation group (3.0 ± 0.3 vs. 3.1 ± 0.3mm; p = 0.27). At 2-year follow-up, the TLF occurred in five (4.2%), TLR in four (3.4%), and target vessel revascularization (TVR) in five (4.2%) cases. The frequency of TLR and TVR was higher in the non-bifurcation group (p = 0.04 and 0.02, respectively), but there were no differences in TLF between the two groups (p = 0.17). The cumulative incidence of TLF (Kaplan–Meier estimates) was also not different in the two groups (log-rank p = 0.11).ConclusionDCB-only strategy for de novo lesions in large coronary arteries appears to be safe and effective for both bifurcation and non-bifurcation lesions. Further randomized clinical trials are warranted to confirm the value of DCB-only strategy in de novo bifurcation lesions of large vessels.
Nomogram Prediction for the Risk of Diabetic Foot in Patients With Type 2 Diabetes Mellitus
Authors: Wang Jie , Xue Tong , Li Haopeng , Guo Shuai 
Published: July 2022

AimsTo develop and validate a nomogram prediction model for the risk of diabetic foot in patients with type 2 diabetes mellitus (T2DM) and evaluate its clinical application value.MethodsWe retrospectively collected clinical data from 1,950 patients with T2DM from the Second Affiliated Hospital of Xi’an Jiaotong University between January 2012 and June 2021. The patients were divided into training cohort and validation cohort according to the random number table method at a ratio of 7:3. The independent risk factors for diabetic foot among patients with T2DM were identified by multivariate logistic regression analysis. Then, a nomogram prediction model was developed using the independent risk factors. The model performances were evaluated by the area under the receiver operating characteristic curve (AUC), calibration plot, Hosmer–Lemeshow test, and the decision curve analysis (DCA).ResultsMultivariate logistic regression analysis indicated that age, hemoglobin A1c (HbA1c), low-density lipoprotein (LDL), total cholesterol (TC), smoke, and drink were independent risk factors for diabetic foot among patients with T2DM (P &lt; 0.05). The AUCs of training cohort and validation cohort were 0.806 (95% CI: 0.775∼0.837) and 0.857 (95% CI: 0.814∼0.899), respectively, suggesting good discrimination of the model. Calibration curves of training cohort and validation cohort showed a favorable consistency between the predicted probability and the actual probability. In addition, the P values of Hosmer–Lemeshow test for training cohort and validation cohort were 0.826 and 0.480, respectively, suggesting a high calibration of the model. When the threshold probability was set as 11.6% in the DCA curve, the clinical net benefits of training cohort and validation cohort were 58% and 65%, respectively, indicating good clinical usefulness of the model.ConclusionWe developed and validated a user-friendly nomogram prediction model for the risk of diabetic foot in patients with T2DM. Nomograms may help clinicians early screen and identify patients at high risk of diabetic foot.
FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism
Authors: Szczepańska Ewa , Glinicki Piotr , Zgliczyński Wojciech , Słowińska-Srzednicka Jadwiga , Jastrzębska Helena , Gietka-Czernel Małgorzata 
Published: July 2022

BackgroundFGF21 pharmacological treatment reverses fatty liver and lowers serum triglyceride concentration but FGF21 serum level is increased in hepatic steatosis. FGF21 secretion is induced by thyroid hormones in vitro.PurposeTo determine the influence of thyroid hormones and metabolic changes secondary to thyroid dysfunction on FGF21 secretion in humans.Materials and MethodsThis was a case-control study. 82 hyperthyroid and 15 hypothyroid patients were recruited together with 25 healthy controls. Of those with hyperthyroidism, 56 received radioiodine treatment and 42 of them achieved hypothyroidism and then euthyroidism within one year following therapy. Radioiodine-induced hypothyroidism developed abruptly within a six week interval between clinic visits. FGF21 serum levels were determined with an ELISA method.ResultsSerum FGF21 levels did not differ in hyper- and hypothyroid patients in comparison to controls [median 103.25 (interquartile range, 60.90-189.48) and 86.10 (54.05-251.02) vs 85.20 (58.00-116.80) pg/mL P=0.200 and 0.503, respectively]. In hyperthyroid patients treated with radioiodine, serum FGF21 levels increased significantly in rapid-onset hypothyroidism in comparison to the hyperthyroid and euthyroid phase [median 160.55 (interquartile range, 92.48 - 259.35) vs 119.55 (67.78-192.32) and 104.43 (55.93-231.93) pg/mL, P=0.034 and 0.033, respectively]. The rising serum FGF21 level correlated positively with serum triglycerides (Spearman coefficient rs=0.36, P=0.017) and inversely with serum SHBG (rs=-0.41, P=0.007), but did not correlate with thyroid hormone levels.ConclusionsThere was a transient increase in FGF21 serum level during rapid-onset hypothyroidism following radioiodine treatment. There was no association between FGF21 serum level and thyroid hormones. In radioiodine-induced hypothyroidism, the rising serum FGF21 concentration correlated positively with rising serum triglycerides and negatively with falling SHBG, reflecting increased hepatic lipogenesis.
Strength and Energy Evolution Law of Deep-Buried Granite Under Triaxial Conditions
Authors: Guo Guangtao , Xu Dingping , Feng Guangliang , Wu Xiaogang , Zhou Yuxin 
Published: July 2022

With the increasing global demand for clean and renewable energy sources, many underground hydropower caverns are built in deep mountain valleys in high-stress regions. The evolution of the mechanical properties of the surrounding rock of underground caverns under high-stress excavation requires urgent investigation. According to the deep-buried granite in the underground caverns of the Shuangjiangkou hydropower station, triaxial tests under confining pressures of 10, 30, 40, and 50 MPa were conducted by the MTS815 rock mechanics test system. Based on the stress–strain curve, the evolution law of the strength parameters of rock samples with the crack volume strain and energy with the energy consumption ratio under different confining pressures was analyzed. Our results showed that the stress–strain curve of the sample is divided into five stages with four characteristic points: the closed point, initiation point, volume expansion point, and peak point. The strength of each stage increases with an increase in the confining pressure. In addition, the failure of this granite is characterized by apparent shear failure. The internal friction angle and the cohesion increase rapidly with the increase in the crack volume strain, and they gradually tend to be constant. Furthermore, the confining pressure profoundly influences energy evolution during the loading in the stable and unstable crack growth stages. In these stages, total energy, dissipated energy, and elastic strain energy increase with an increase in the confining pressure. Finally, the energy consumption ratio can represent the preliminary criterion of rock failure in terms of energy. With the increase in the confining pressure, the energy consumption ratio of rock samples gradually increases to approximately 1.0 at the peak stress point. The research results can provide a reference for the instability prediction of surrounding rock masses of high-stress underground caverns.
Case Report: Pathogenesis With a Rare RHOA A161E Mutation in a Patient With Angioimmunoblastic T-Cell Lymphoma
Authors: Cao Lihong , Tong Hongyan , Liu Xing , Xu Yingqing , Yu Fang , Pan Qi , Lai Jin , Huang Jian , Qin Jiayue , Jin Jie 
Published: July 2022

Angioimmunoblastic T-cell lymphoma (AITL) genomic abnormalities are highly disease-specific, and the ras homology family member A (RHOA) gene is one of the most recurrent mutated genes, especially for RHOA G17V mutation site. Here, we identified a rare RHOA A161E mutation in an AITL patient through gene sequencing platforms. The patient presented with persistent hypereosinophilia, asymptomatic or symptomatic mildly for over 3 years. At diagnosis, this patient manifested night sweats, weight loss, multiple lymphadenopathies, and enlargement of the liver and spleen. We performed a retrospective genetic mutation analysis by whole-exome sequencing (WES) and droplet digital PCR (ddPCR) on serial gastric, intestinal, and lymph node specimens. The genetic mutation testing result demonstrated that a rare RHOA A161E mutation was found, which was elevated significantly on diagnosis related to AITL pathogenesis. Our case confirms that genetic mutation testing is helpful for diagnostic classification in AITL and dynamic monitoring of gene mutations at multiple time points may facilitate early detection of disease diagnosis.