bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kill Two Birds with One Stone: A Multifunctional Dual‐Targeting Protein Drug to Overcome Imatinib Resistance in Philadelphia Chromosome‐Positive Leukemia
Authors: Ma Bohan , Feng Hui , Feng Chao , Liu Yi , Zhang Hailing , Wang Jincheng , Wang Wenjuan , He Pengcheng , Niu Fan 
Published: March 2022

AbstractThe Bcr/Abl plays a central role in Philadelphia chromosome‐positive (Ph+) leukemia because of the constitutively activated Abl tyrosine kinase and its downstream pathways. Currently, the clinical treatment of imatinib‐resistant patients with tyrosine kinase inhibitors is severely limited by drug resistance and adverse effects. Herein, a dual‐targeting proteolysis‐targeting chimera (PROTAC) protein drug, termed PMIBcr/Abl‐R6, is designed by engrafting an MDM2/p53 inhibition peptide sequence onto the Bcr/Abl tetramerization domain. PMIBcr/Abl‐R6, harboring a Bcr/Abl targeting sequence and an MDM2 binding sequence, acts as a PROTAC drug in Ph+ leukemia cells. Its dual‐targeting constitution suggests that PMIBcr/Abl‐R6 designs to target the tetramerization domain instead of the Abl kinase domain, therefore has the potential to overcome drug resistance mutations in the kinase domain. The efficient ability of PMIBcr/Abl‐R6 is demonstrated to simultaneously induce Bcr/Abl degradation and activate the p53 pathway. PMIBcr/Abl‐R6 has the potential to overcome drug resistance in Ph+ leukemias by multiple mechanisms.
Ancient DNA analysis reveals temporal and geographical patterns of mitochondrial diversity in pre‐Hispanic populations from Central Argentina
Authors: Nores Rodrigo , Tavella María Pía , Fabra Mariana , Demarchi Darío A. 
Published: March 2022

AbstractObjectivesThe study of the ancient populations of Central Argentina has a crucial importance for our understanding of the evolutionary processes in the Southern Cone of South America, given its geographic position as a crossroads. Therefore, the aim of this study is to evaluate the temporal and geographical patterns of genetic variation among the groups that inhabited the current territory of Córdoba Province during the Middle and Late Holocene.MethodsWe analyzed the mitochondrial haplogroups of 74 individuals and 46 Hypervariable Region I (HVR‐I) sequences, both novel and previously reported, from archeological populations of the eastern Plains and western Sierras regions of the province of Córdoba. The HVR‐I sequences were also compared with other ancient groups from Argentina and with present‐day populations from Central Argentina by pairwise distance analysis and identification of shared haplotypes.ResultsSignificant differences in haplogroup and haplotype distributions between the two geographical regions were found. Sierras showed genetic affinities with certain ancient populations of Northwestern Argentina, while Plains resembled its neighbors from Santiago del Estero Province and the Pampas region. We did not observe genetic differences among the pre 1200 and post 1200 yBP temporal subsets of individuals defined by the emergence of horticulture, considering both geographical samples jointly.ConclusionsThe observed patterns of geographical heterogeneity could indicate the existence of biologically distinct populations inhabiting the mountainous region and the eastern plains of Córdoba Province in pre‐Hispanic times. Maternal lineages analyses support a scenario of local evolution with great temporal depth in Central Argentina, with continuity until the present.
Malnutrition in Maya children: High prevalence of linear growth deficiency
Authors: May‐Kim Shérlin , Peña‐Espinoza Barbara Itzel , Menjivar Marta 
Published: March 2022

AbstractObjectivesMexican children suffer a double burden of malnutrition, which implicates the coexistence of undernourishment‐related growth restriction and overweight/obesity. Malnutrition is often related to food insecurity due to nutrition transition that affects indigenous communities and increases the risk of metabolic alterations. In this work, we describe the nutritional and metabolic status in school‐age Maya children from rural areas.Materials and methodsWe evaluated school‐age children (n = 96; 8–10 years) from Maya communities of Yucatan by measuring anthropometric, clinical, and biochemical variables. Linear growth deficiency was defined as short stature when height‐for‐age was below the z‐score (under −1SD a −2SD).ResultsWe observed an overall prevalence of linear growth deficiency of 53% and a prevalence of 39% of overweight/obesity in the studied children. Among the children with growth restriction, 22% presented overweight/obesity, 37% cardiometabolic risk, and 10% had a high percentage of fat mass. Unsurprisingly, 62% of the children with growth restriction had a deficiency of arm muscle area (≤15th percentile) that probably explains the weakness of handgrip strength that we observed. Furthermore, this group of children also presented hypertriglyceridemia (50%), high‐blood pressure (39%), hypoalphalipoproteinemia (24%), hyperglycemia (11%), and hypercholesterolemia (2%).DiscussionThis study showed the coexistence of extreme nutritional conditions in indigenous communities. Also, we demonstrated the latent risk of Maya children with growth deficiency toward chronic degenerative diseases.
An isotope signature for diffuse idiopathic skeletal hyperostosis?
Authors: Castells Navarro Laura , Buckberry Jo , Beaumont Julia 
Published: March 2022

AbstractObjectivesDiffuse idiopathic skeletal hyperostosis (DISH) has recurrently been associated with a rich diet (high in protein and higher trophic level foods); however, very few studies have investigated this link using carbon and nitrogen (δ13C and δ15N) stable isotope analysis. This paper explores the relationship between DISH and diet in two Roman urban communities by analyzing individuals with and without DISH.Materials and methodsδ13C and δ15N analysis carried out on collagen from 33 rib samples (No DISH: 27; early DISH: 4; DISH: 2) selected from individuals buried at the Romano‐British site of Baldock (UK), 41 rib samples (No DISH: 38; early DISH: 3) from individuals from the Catalan Roman site of Santa Caterina (Barcelona, Spain). Additionally, six faunal samples from Baldock and seven from Santa Caterina were analyzed.ResultsStandardized human isotope data from Santa Caterina show high δ15N probably associated to a diet combining terrestrial resources and freshwater fish. In contrast, isotope results from Baldock suggest a terrestrial‐based diet. Individuals with DISH do not show isotopic ratios indicative of rich diet and there is no correlation between stage of DISH development and δ13C and δ15N.ConclusionThe results of this study suggest that individuals with DISH followed a similar or isotopically similar diet as those individuals without DISH in Baldock and in Santa Caterina and therefore, while DISH may have been influenced by individual's dietary habits, this is not reflected in their isotopic signature.
Relationship between oil binding capacity and physical properties of interesterified soybean oil
Authors: Abigail Marsh Melissa , Martini Silvana 
Published: March 2022

AbstractThe objective of this study was to identify the physical properties of an interesterified soybean oil (EIESOY), containing 45% saturated fatty acids (SFA), that correlates with high oil binding capacity (OBC) and low oil loss (OL). In this study, three EIESOY samples were analyzed; a 100% sample, a 50% sample diluted with 50% soybean oil, and a 20% sample diluted with 80% soybean oil. All samples were crystallized using fast (7.78°C/min) and slow (0.1°C/min) cooling rates as well as with and without high‐intensity ultrasound (HIU, 20 kHz). The 100%, 50%, and 20% samples were crystallized at 38.5, 27.0, and 22.0°C, respectively. HIU was applied at the onset of crystallization and all samples were allowed to crystallize isothermally for 90 min. After 90 min, physical properties such as crystal microstructure, hardness, solid fat content (SFC), elasticity, and melting behavior were evaluated. Physical properties were also measured after storage for 48 h at 22 and 5°C. Results show that OBC was positively correlated with hardness, G′, and SFC after 48 h (r = 0.738, p = 0.006; r = 0.639, p = 0.025; r = 0.695, p = 0.012; respectively), OL was negatively correlated with hardness after 48 h (r = −0.696, p < 0.001), G′ after 90 min and 48 h (r = −0.704, p < 0.001; r = −0.590, p = 0.002), and SFC after 90 min and 48 h (r = −0.722, p < 0.001; r = −0.788, p < 0.001). Neither OBC nor OL were correlated with crystal diameter or the number of crystals.
Fabrication, characterization and properties of silane functionalized graphene oxide/silicone rubber nanocomposites
Authors: Sarath Pampayil Sasikumar , Thomas Sabu , Haponiuk Józef T. , George Soney C. 
Published: March 2022

AbstractIn this work, octadecyl trichlorosilane (ODTS) was used to modify the surface of graphene oxide. Further, varied concentrations of silane‐modified graphene oxide were used to make silicone rubber nanocomposite. The mechanical, thermal, and tribological properties of the composite were studied. The results showed that a small amount of silane‐modified graphene oxide significantly increased the mechanical and tribological performances. Under dry sliding, silane‐modified graphene oxide to the silicone matrix significantly reduced wear and friction properties. Nanocomposites have a lower wear rate than neat silicone rubber; their friction coefficient is almost 36% less than pure silicone rubber: the higher the load and temperature conditions, the more significant the difference in friction and properties. Wear mechanisms were revealed by scanning electron micrographs of the worn surface. The transfer film formation on the counter surface and acceptable wear debris improved the nanocomposites friction and wear resistance characteristics.
Synthesis and Self‐assembly of Benzoperylene Benzimidazoles: Tunable Morphology with Aggregation‐Induced Enhanced Emission
Authors: Srideep Dasari , Sriram Kasilingam , Kotha Srinu , Babu Deepu J. , Singh Saurabh Kumar , Rao Kotagiri Venkata 
Published: March 2022

AbstractBenzoperylene benzimidazoles (BPBIs) based π‐systems were synthesized and their self‐assembly in both non‐polar and polar solvents investigated. Due to the presence of donor and acceptor functional groups, BPBIs absorb light up to 600 nm and display red fluorescence (575–800 nm). Depending on the solvent and side chain, BPBIs self‐assemble into various nanostructures such as nanoribbons, nanorods, nanofibers and nanoparticles. Notably, these ordered nanostructures are formed by BPBIs in both polar and non‐polar solvents without the aid of hydrogen bonding and amphiphilic interactions due to the presence of a large rigid π‐system. Interestingly, BPBIs follow a weakly cooperative mechanism during the self‐assembly. Moreover, BPBIs show aggregation‐induced enhanced emission (AIEE) in all the self‐assembled nanostructures which is not common for rigid π‐systems.
Highly‐fluorinated Triaminocyclopropenium Ionic Liquids
Authors: Curnow Owen J. , Senthooran Rathiga 
Published: March 2022

AbstractA series of highly‐fluorinated triaminocyclopropenium salts, with up to six fluorous groups, were prepared and their properties as ionic liquids investigated. Reaction of pentachlorocyclopropane or tetrachlorocyclopropene with bis(2,2,2‐trifluoroethyl)amine, HN(CH2CF3)2, occurs in the presence of a trialkylamine, NR3, to give cations with two fluorinated amino groups, [C3(N(CH2CF3)2)2(NR2)]+ (R=Et, Pr, Bu, Hex), with traces of [C3(N(CH2CF3)2)3]+. Use of appropriate reagent ratios and reaction times and subsequent addition of a dialkylamine, HNR'R”, gives cations with one fluorinated amino group, [C3(N(CH2CF3)2)(NR2)(NR'R”)]+ ((NR2)(NR'R”)=(NBu2)2, (NEt2)(NPr2), (NBu2)(NBuMe)). These cations were isolated as chloride salts and some of these were converted to bistriflamide, dicyanamide and triflate salts to provide ionic liquids. These salts were characterised by thermal (DSC and TGA) measurements and miscibility/solubility properties (determined in a range of solvents). Ionic liquids (ILs) were also characterised by density, viscosity and conductivity measurements where possible. X‐ray diffraction studies of chloride salts showed the formation of fluorous regions and more hydrophilic ionic regions in the solid state.
Optimal design of a novel high‐performance passive non‐traditional inerter‐based dynamic vibration absorber for enhancement vibration absorption
Authors: Baduidana Marcial , Kendo‐Nouja Berline , Kenfack‐Jiotsa Aurelien , Nzengwa Robert 
Published: March 2022

AbstractThis paper proposes a novel high‐performance passive non‐traditional inerter‐based dynamic vibration absorber (NIDVA), tuned by the H∞ optimization using the patternsearch solver in MATLAB with the starting points, the optimum parameters based on the extended fixed points theory (EFPT). Then, the control performance of the proposed NIDVA is compared with the classic DVA and the high‐performance passive non‐traditional inerter‐based dynamic vibration absorber (NIDVA‐C4). Based on the optimum parameters under harmonic force excitation, the relative dynamic performance index (%RDP) of the proposed NIDVA registered improvements of 31%–63% and 54%–72% with respect to the NIDVA‐C4 and classic DVA, respectively, considering the mass ratio range from 1% to 10%. Regarding the suppression bandwidth index (%SB) for the mass ratio of 5%, the NIDVA can enlarge the SB by 50% and 62% with respect to NIDVA‐C4 and classic DVA, respectively. For the white noise excitation, more than 38%–64% and 53%–69% improvement of random vibration reduction can be obtained from NIDVA with respect to NIDVA‐C4 and classic DVA, respectively. Accordingly, results of this study provide some technical information to design more effective vibration control device in engineering practices.
Factors affecting transtemporal window quality in transcranial sonography
Authors: He Lei , Wu Dong‐Fang , Zhang Jing‐Han , Zheng Shuai , Li Yi , He Wen 
Published: March 2022

AbstractObjectiveTo assess the influencing factors of transtemporal window quality and identify patients suitable for transcranial sonography (TCS) examination in two‐dimensional imaging.MethodsIn this cross‐sectional study, TCS was performed in 161 consecutive patients through the temporal bone window (TBW) in the neurology or neurosurgery department. Each patient's sex, age, height, weight, and temporal bone thickness (TBT) were collected. After examination, the patients were divided into two groups: TBW success and TBW failure. The data were statistically compared between the two groups.ResultsAmong the studied population, the total TBW success rate was 80.1% (95% confidence interval [CI]: 74–86). The TBW success rate was 91.4% (95% CI: 85–98) in males and 70.9% (95% CI: 61–81) in females (p = .001). Sex (p = .001), age (p = .002), height (p = .047), and TBT (p < .001) showed significant differences between the TBW success and failure groups. In males, only TBT (p = .001) showed a significant difference; in females, age (p < .001) and TBT (p = .003) showed a significant difference. The area under the receiver operating characteristic curve (AUC) of sex, age, and TBT and their combination was 0.686, 0.659, 0.842, and 0.922 (p < .001), respectively. The AUC of the combination of parameters was significantly greater than that of age and sex alone (p = .007; p = .0002) but not greater than that of TBT (p = .090).ConclusionsThe TBW success rate varied with sex, age, height, and TBT. Males, younger patients, taller patients, and patients with a thinner temporal bone tended to be more suitable for the examination by TCS.
What motivates environmental and social sustainability in family firms? A cross‐cultural survey
Authors: Nikolakis William , Olaru Doina , Kallmuenzer Andreas 
Published: March 2022

AbstractEvidence shows that positive family dynamics can motivate environmental and social strategies (ESS) in family firms. Using a stated choice method, we examine how family conflict, trust and socioemotional wealth (SEW) influence ESS choices and interact with other trade‐offs among family firms in two distinct cultural contexts: Chile and India. In Chile, we found that where there was more conflict, there were less ESS choices selected. However, in Chile, higher trust produced less relational conflict and more ESS preferences, suggesting supportive norms and group cohesion in these firms. Chilean respondents selected ESS choices more generally, which may be influenced by cultural dimensions that support sustainability, like uncertainty avoidance, indulgence and collectivism. Formal written sustainability visions in family firms created positive environmental norms in both countries and in Chile led to higher ESS preferences. Indian respondents with higher SEW were more likely to adopt ESS choices. Younger family firms in both countries were more likely to adopt ESS, suggesting generational dynamics and selectivity theory may be at play. Creating safeguards for maintaining positive emotional dynamics and tools for creating formal sustainability visions are important steps for enabling ESS among family firms.
Is cardiac surgery backup required for left main stenting?
Authors: Khan Asaad A. , Dangas George 
Published: March 2022

Key Points

Although CABG is the gold standard treatment for left main disease, PCI is a suitable alternative based on several clinical studies.
The high‐risk features of left main PCI due to technically challenging anatomy as well as unfavorable clinical factors, typically mandates a cardiothoracic surgery backup.
Emerging registry data suggest left main PCI can be safely performed without on‐site surgical backup.
Flower‐like Mesoporous Carbon with Cobalt Sulfide Nanocrystalline as Efficient Bifunctional Electrocatalysts for Zn‐Air Batteries
Authors: Zhou Haoran , Fan Fei , Yu Hailin , Xu Yuanhao , Yuan Chengyun , Wang Yinghan 
Published: March 2022

AbstractTransition‐metal sulfides have gained considerable attention for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in rechargeable Zn‐air batteries owing to their natural abundance, chemical stability, and efficient activity. Here, cobalt sulfide nanocrystalline supported on the 3D hierarchically flower‐like porous nanocarbon (mC‐CoSx‐50) electrocatalysts have been synthesized through a combination of metal‐organic complexation and porous silica templates for efficient bifunctional oxygen catalysis. With the high specific surface area, high nitrogen content and heteroatom doping, the as‐synthesized mC‐CoSx‐50 exhibits an excellent bifunctional oxygen catalytic performance. Remarkably, the rechargeable Zn‐air batteries assembled with the cobalt sulfide‐based hierarchically porous electrocatalysts reveal a high peak power density and excellent cycling stability in comparison with Pt/C+RuO2 owing to the synergistic effects between cobalt sulfide nanocrystallines and hierarchically porous carbon. We envision that this work not only offers high‐performance metal sulfide for future clean energy conversion but also provides a facial strategy for constructing hierarchically porous carbon‐supported catalyst.
Hollow Zeolites‐Confined Isolated (ZnOH)+ Enable High Selectivity and Stability for Methanol to Aromatics
Authors: Wang Kai , Ge Huibin , Qin Yong 
Published: March 2022

AbstractThe methanol‐to‐aromatics process has great potential to meet the growing global consumption for aromatics, but the widely used metal modified strong acid zeolites, such as Zn/ZSM‐5, usually suffer from unsatisfactory aromatic selectivity and short time‐on‐stream stability. A new Zn/ZSM‐5 based catalyst with only isolated (ZnOH)+ species and a cavity core was synthesized by using a new inorganic‐organic hybrid aluminosilicates sphere, which was fabricated with the assistance of electrostatic assembly. Isolated (ZnOH)+ species can improve the selectivity to aromatics and minimize the negative influence of diffusion simultaneously. Meanwhile, the core cavity can provide more space to deposit coke. Thus, the prepared HL−Zn(DS)/HZSM‐5 zeolite exhibited the superior aromatics selectivity of 50.63 % with a WHSV of 3.18 h−1 at 390 °C and 0.5 MPa. Moreover, the catalyst can afford an extremely low deactivation constant of 0.0097 mg/h with an enhanced lifetime up to 131 h and strong regeneration ability.
Anthracene‐Walled Acyclic CB[n] Receptors: in vitro and in vivo Binding Properties toward Drugs of Abuse
Authors: DiMaggio Delaney , Brockett Adam T. , Shuster Michael , Murkli Steven , Zhai Canjia , King David , O'Dowd Brona , Cheng Ming , Brady Kimberly , Briken Volker , Roesch Matthew R. , Isaacs Lyle 
Published: March 2022

AbstractWe report studies of the interaction of six acyclic CB[n]‐type receptors toward a panel of drugs of abuse by a combination of isothermal titration calorimetry and 1H NMR spectroscopy. Anthracene walled acyclic CB[n] host (M3) displays highest binding affinity toward methamphetamine (Kd=15 nM) and fentanyl (Kd=4 nM). Host M3 is well tolerated by Hep G2 and HEK 293 cells up to 100 μM according to MTS metabolic and adenylate kinase release assays. An in vivo maximum tolerated dose study with Swiss Webster mice showed no adverse effects at the highest dose studied (44.7 mg kg−1). Host M3 is not mutagenic based on the Ames fluctuation test and does not inhibit the hERG ion channel. In vivo efficacy studies showed that pretreatment of mice with M3 significantly reduces the hyperlocomotion after treatment with methamphetamine, but M3 does not function similarly when administered 30 seconds after methamphetamine.
Global, regional, and national cancer deaths and disability‐adjusted life‐years (DALYs) attributable to alcohol consumption in 204 countries and territories, 1990‐2019
Authors: Safiri Saeid , Nejadghaderi Seyed Aria , Karamzad Nahid , Carson‐Chahhoud Kristin , Bragazzi Nicola Luigi , Sullman Mark J. M. , Almasi‐Hashiani Amir , Mansournia Mohammad Ali , Collins Gary S. , Kaufman Jay S. , Kolahi Ali‐Asghar 
Published: March 2022

BackgroundAlcohol consumption is a risk factor for a number of communicable and non‐communicable diseases, including several types of cancer. This article reports the burden of cancers attributable to alcohol consumption by age, sex, location, sociodemographic index (SDI), and cancer type from 1990 to 2019.MethodsThe Comparative Risk Assessment approach was used in the 2019 Global Burden of Disease study to report the burden of cancers attributable to alcohol consumption between 1990 and 2019.ResultsIn 2019, there were globally an estimated 494.7 thousand cancer deaths (95% uncertainty interval [UI], 439.7 to 554.1) and 13.0 million cancer disability‐adjusted life‐years (DALYs; 95% UI, 11.6 to 14.5) that were attributable to alcohol consumption. The alcohol‐attributable DALYs were much higher in men (10.5 million; 95% UI, 9.2 to 11.8) than women (2.5 million; 95% UI, 2.2 to 2.9). The global age‐standardized death and DALY rates of cancers attributable to alcohol decreased by 14.7% (95% UI, 6.4% to 23%) and 18.1% (95% UI, 9.2% to 26.5%), respectively, over the study period. Central Europe had the highest age‐standardized death rates that were attributable to alcohol consumption(10.3; 95% UI, 8.7 to12.0). Moreover, there was an overall positive association between SDI and the regional age‐standardized DALY rate for alcohol‐attributable cancers.ConclusionsDespite decreases in age‐standardized deaths and DALYs, substantial numbers of cancer deaths and DALYs are still attributable to alcohol consumption. Because there is a higher burden in males, the elderly, and developed regions (based on SDI), these groups and regions should be prioritized in any prevention programs.