bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fifty‐year history of the evolution of spinal metastatic disease management
Authors: Newman W. Christopher , Bilsky Mark H. 
Published: September 2022

AbstractSpine metastases are a significant source of morbidity in oncology. Treatment of these spine metastases largely remains palliative, but advances over the past 50 years have improved the effectiveness of interventions for preserving functional status and obtaining local control while minimizing morbidity. While the field began with conventional external beam radiation as the primary treatment modality, a series of paradigm shifts and technological advances in the 2000s led to a change in treatment patterns. These advances allowed for an increased role of surgical decompression of neural elements, a shift in the stereotactic capabilities of radiation oncologists, and an improved understanding of the radiobiology of metastatic disease. The result was improved local control while minimizing treatment morbidity. These advances fit within the larger framework of metastatic spine tumor management known as the Neurologic, Oncologic, Mechanical, and Systemic disease decision framework. This dynamic framework takes into account the neurological function of the patient, the radiobiology of their tumor, their degree of mechanical instability, and their systemic disease control and treatment options to help determine appropriate interventions based on the individual patient. Herein, we describe the 50‐year evolution of metastatic spine tumor management and the impact of various advances on the field.
Fifty years of pancreas cancer care
Authors: Brennan Murray F. , Allen Peter J. , Jarnagin William R. 
Published: September 2022

AbstractResulting from 50 years of innovation, operations for pancreatic neoplasms can now be performed safely, albeit with significant but manageable morbidity. Molecular diagnosis has allowed for the identification of multiple distinct histopathologies with variable natural histories. Observation is now a strategy for selected indolent cysts and some neuroendocrine neoplasms. For ductal pancreatic adenocarcinoma, a long‐term cure remains elusive and will require more than surgical resection for meaningful progress.
Genitourinary tumors
Authors: Herr Harry , Sogani Pramod , Eastham James 
Published: September 2022

AbstractMemorial Sloan Kettering Cancer Center (MSK) has made many notable contributions to the scientific understanding and care of patients with common urologic cancers. Many of the advances represented paradigm shifts in management and established new standards of care. This review highlights the surgical procedures and treatment strategies originated and pioneered by urologic surgeons and colleagues at MSK during the past 50 years.
Five decades of progress in surgical oncology: Tumors of the lung and esophagus
Authors: Rusch Valerie W. 
Published: September 2022

AbstractDuring the past 50 years, there has been a remarkable transformation in the management of lung and esophageal cancers. Improved methods of diagnosis, better staging and patient selection for surgery, the advent of minimally invasive approaches to resection, decreasing operative mortality, greater insights into tumor biology, and the development of effective multimodality therapies and precision medicine have contributed to this transformation. Progress has been most notable in lung cancer.
Five decades of progress in surgical oncology: Breast
Authors: Downs‐Canner Stephanie , Cody Hiram S. 
Published: September 2022

AbstractSurgery remains the single most effective treatment for breast cancer but coincident with a deeper understanding of tumor biology and advances in multidisciplinary care (encompassing breast imaging, systemic adjuvant therapy, radiotherapy, and genomics) continues to de‐escalate, supported by strong level I data. We have moved from mastectomy to breast conservation, and from routine axillary dissection to sentinel lymph node biopsy to selective omission of axillary node staging altogether. We have further de‐escalated through consensus over margin width in breast conservation, through improvements in neoadjuvant therapy, and by demonstrating no benefit for upfront surgery in patients with stage IV disease. For patients with ipsilateral breast tumor recurrence, reconservation surgery and reirradiation are promising. Cell cycle and immune checkpoint inhibitors, when added to conventional systemic therapy, have now moved beyond stage IV disease to phase III trials in the adjuvant and neoadjuvant settings, promising even further de‐escalation of surgery. Finally, with genomic profiling we are moving away from the primacy of axillary node status for prognostication and into a new era allowing prediction of response to therapy.
Progress in surgical oncology: Gynecology perspective
Authors: Abu‐Rustum Nadeem R. 
Published: September 2022

AbstractSince its founding in 1884, Memorial Sloan Kettering Cancer Center (MSK) has set standards of care in gynecologic oncology. Over time, the MSK treatment approach evolved into an effort of gynecologic oncology experts across disciplines. As the anatomic field of gynecologic oncology surgery expanded beyond the pelvis, experts in other fields of cancer care, including our hepatobiliary and thoracic colleagues, joined this interprofessional effort. Here, we describe recent, key contributions to surgical gynecologic oncology by the Gynecology Service at MSK.
Advances in the management of liver and biliary tumors
Authors: Jarnagin William R. , D'Angelica Michael I. 
Published: September 2022

AbstractOver the past 50 years, the management of liver and biliary tumors has evolved significantly. Initially considered highly morbid and lethal, resection is now the treatment of choice for a significant proportion of patients with malignant and benign hepatobiliary disease. Improved operative/anesthetic techniques, use of parenchymal‐sparing approaches, better patient selection for surgery, effective liver‐directed therapies, and new insights into tumor biology are significant contributors to our transformed approach to hepatobiliary neoplasms.
Fifty years of progress in gastric cancer
Authors: Coit Daniel G. , Strong Vivian E. 
Published: September 2022

AbstractAs with every human malignancy, the diagnosis, staging, and treatment of patients with gastric cancer have undergone enormous evidence‐based change over the last 50 years, largely as a result of increasingly rapid developments in technology and science. Some of the changes in clinical practice have derived from prospective randomized controlled trials (RCTs), whereas others have come from study of meticulously maintained prospective databases, which define the disease's natural history over time, and occasionally from in‐depth analysis of a single patient with an unexpectedly good or poor outcome. Herein we summarize the more important changes in gastric cancer management and the data supporting those changes.
Colorectal cancer
Authors: Paty Philip B. , Garcia‐Aguilar Julio 
Published: September 2022

AbstractAlthough surgery is the established standard and mainstay for treatment of colorectal cancer, advances in technology and clinical trials over the past 50 years have dramatically expanded and improved the detection, staging, treatment, and understanding of this disease. This review highlights contributions by surgeons, oncologists, gastroenterologists, engineers, and scientists to increase postsurgical recurrence‐free survival, reduce the time and toxicity of treatment, and improve the quality of life for patients over the past half‐century.
Study the key biogenic amines in luncheon meat by capillary electrophoresis with indirect ultraviolet detection
Authors: Wang Rong , Xu Zhongqi , Yang Xue 
Published: September 2022

In this work, a simple, accurate, and rapid capillary electrophoresis with an indirect ultraviolet detection method was developed to simultaneous separate 10 biogenic amines. It was found that β‐cyclodextrin and ethylene diamine tetraacetic acid facilitated the separation of tryptamine and tyramine, spermidine and spermine, respectively. The optimized background electrolytes consisted of 20.0 mmol/L imidazole, 8.0 mmol/L β‐cyclodextrin, 0.5 mmol/L ethylene diamine tetraacetic acid, and 6.0% methanol (at pH 4.50 adjusted with acetic acid). The total analysis time of this method was less than 11 min with limits of detection in the range of 0.14–1.98 mg/L. The interday relative standard deviation of migration time and peak area were less than 1.36% and 4.44% (n = 6), respectively. To verify the applicability, this method was carried out to analyze biogenic amines in commercial luncheon meat samples. Due to the complex composition of luncheon meat, the real samples were rinsed with deionized water to reduce the influence of matrices. It was found that both storage temperature and protein content of the luncheon meat samples affected the biogenic amines content during storage. The results of this study are instructive for the storage of high‐protein meat products.
Cold‐water coral ecosystems under future ocean change: Live coral performance vs. framework dissolution and bioerosion
Authors: Büscher Janina Vanessa , Form Armin Uwe , Wisshak Max , Kiko Rainer , Riebesell Ulf 
Published: September 2022

AbstractPhysiological sensitivity of cold‐water corals to ocean change is far less understood than of tropical corals and very little is known about the impacts of ocean acidification and warming on degradative processes of dead coral framework. In a 13‐month laboratory experiment, we examined the interactive effects of gradually increasing temperature and pCO2 levels on survival, growth, and respiration of two prominent color morphotypes (colormorphs) of the framework‐forming cold‐water coral Lophelia pertusa, as well as bioerosion and dissolution of dead framework. Calcification rates tended to increase with warming, showing temperature optima at ~ 14°C (white colormorph) and 10–12°C (orange colormorph) and decreased with increasing pCO2. Net dissolution occurred at aragonite undersaturation (ΩAr < 1) at ~ 1000 μatm pCO2. Under combined warming and acidification, the negative effects of acidification on growth were initially mitigated, but at ~ 1600 μatm dissolution prevailed. Respiration rates increased with warming, more strongly in orange corals, while acidification slightly suppressed respiration. Calcification and respiration rates as well as polyp mortality were consistently higher in orange corals. Mortality increased considerably at 14–15°C in both colormorphs. Bioerosion/dissolution of dead framework was not affected by warming alone but was significantly enhanced by acidification. While live corals may cope with intermediate levels of elevated pCO2 and temperature, long‐term impacts beyond levels projected for the end of this century will likely lead to skeletal dissolution and increased mortality. Our findings further suggest that acidification causes accelerated degradation of dead framework even at aragonite saturated conditions, which will eventually compromise the structural integrity of cold‐water coral reefs.
Training the next generation of learning health system scientists
Authors: Lozano Paula M. , Lane‐Fall Meghan , Franklin Patricia D. , Rothman Russell L. , Gonzales Ralph , Ong Michael K. , Gould Michael K. , Beebe Timothy J. , Roumie Christianne L. , Guise Jeanne‐Marie , Enders Felicity T. , Forrest Christopher B. , Mendonca Eneida A. , Starrels Joanna L. , Sarkar Urmimala , Savitz Lucy A. , Moon JeanHee , Linzer Mark , Ralston James D. , Chesley Francis D. 
Published: September 2022

AbstractIntroductionThe learning health system (LHS) aligns science, informatics, incentives, stakeholders, and culture for continuous improvement and innovation. The Agency for Healthcare Research and Quality and the Patient‐Centered Outcomes Research Institute designed a K12 initiative to grow the number of LHS scientists. We describe approaches developed by 11 funded centers of excellence (COEs) to promote partnerships between scholars and health system leaders and to provide mentored research training.MethodsSince 2018, the COEs have enlisted faculty, secured institutional resources, partnered with health systems, developed and implemented curricula, recruited scholars, and provided mentored training. Program directors for each COE provided descriptive data on program context, scholar characteristics, stakeholder engagement, scholar experiences with health system partnerships, roles following program completion, and key training challenges.ResultsTo date, the 11 COEs have partnered with health systems to train 110 scholars. Nine (82%) programs partner with a Veterans Affairs health system and 9 (82%) partner with safety net providers. Clinically trained scholars (n = 87; 79%) include 70 physicians and 17 scholars in other clinical disciplines. Non‐clinicians (n = 29; 26%) represent diverse fields, dominated by population health sciences. Stakeholder engagement helps scholars understand health system and patient/family needs and priorities, enabling opportunities to conduct embedded research, improve outcomes, and grow skills in translating research methods and findings into practice. Challenges include supporting scholars through roadblocks that threaten to derail projects during their limited program time, ranging from delays in access to data to COVID‐19‐related impediments and shifts in organizational priorities.ConclusionsFour years into this novel training program, there is evidence of scholars' accomplishments, both in traditional academic terms and in terms of moving along career trajectories that hold the potential to lead and accelerate transformational health system change. Future LHS training efforts should focus on sustainability, including organizational support for scholar activities.
Synthesis and Evaluation of Anticancer Activity of Hyaluronic Acid/Vanillin Conjugates
Authors: Abla Maher , Waked Anthony , Trombotto Stéphane , Maalouf Mira 
Published: September 2022

AbstractNatural phenolic compounds are known not only for their multiple bioactivities but also for their low bioavailability and rapid metabolism in the systemic circulation. It is well‐known that grafting these phenolic compounds to bio‐based polymers such as hyaluronic acid (HA), has the advantage to increase their stability and water solubility. HA has CD44 receptors that are overexpressed on cancer cells. This makes from HA an interesting vector for antitumor drug delivery systems. The work reported herein describes the synthesis and the structural characterization of HA/vanillin conjugates as well as the size and shape of their aqueous microassemblies using dynamic light scattering and scattering electron microscopy. Finally, investigation on the bioactivity of such conjugates demonstrates that grafting vanillin to HA improves significantly its cytotoxicity against MDA‐MB231 cancer cells in both dose and time‐dependent manner, and reduces the migration ability as well as the number and the volume of breast cancer spheres.
Efficient Synthesis of Macromolecular DO3A@Gn Derivatives for Potential Application in MRI Diagnostics: From Polymer Conjugates to Polymer Nanoparticles
Authors: Kampmann Anne‐Larissa , Hiller Wolf , Weberskirch Ralf 
Published: September 2022

AbstractHerein, the synthesis of three different macromolecular DO3A@Gn conjugates based on poly(2‐oxazoline)s is presented. Therefore, poly(2‐methyl‐2‐oxazoline) is synthesized by a ring‐opening, cationic polymerization and the polymerization is terminated with DO3A(tBu)3. The best results are obtained after 48 h at 120 °C with degree of termination of 86%. After deprotection of the DO3A ligand and complexation with Gn3+, relaxivity as measured with a magnetic field strength of 9.4 T (400 MHz) reveals values for r1 of up to 2.32 mm−1 s−1. The concept is extended to a block copolymer based on 2‐heptyl‐2‐oxazoline and 2‐methyl‐2‐oxazoline that is again terminated with DO3A(tBu)3 to form micelles with a size of 12.6 ± 0.7 nm after DO3A(tBu)3 termination and deprotection of the 1,4,7,10‐tetraazacyclododecane‐N,N,N,N‐tetraacetic acid ligand. After complexation with Gn3+, relaxivity r1 is 10.1 mm−1 s−1 as determined from the slope of the plot of 1/T1 against the gadolinium(III) concentration at 9.4 T. Finally, crosslinked nanoparticles are prepared from amphiphilic macro‐monomers that form micelles in water and are crosslinked throughout the core in the presence of azoisobutyronitrile (AIBN). The nanoparticle is 32.9 ± 7.8 nm in size after Gn3+ complexation and reveals a relaxivity r1 of 6.77 mm−1 s−1.
Effect of Martensitic Transformation of NiTi Particles on Temperature Sensitivity of Flexible VGCF/PDMS Films
Authors: Li Teng , Li Jiaqi , Liu Dongyu , Gong Shen , Wu Chanyuan , Zhu Zhenghong 
Published: September 2022

AbstractA novel NiTi/vapor grown carbon fiber (VGCF)/polydimethylsiloxane flexible film is successfully prepared, of which the resistivity can keep stable under various strain deformation. By introducing NiTi particles with appropriate phase transition temperature, the resistivity change value of the composite in the temperature range can be doubled without affecting the flexibility of the composite. A computer simulation based on percolation network (PN) theory and Monte Carlo (MC) calculation is developed to understand the mechanisms of resistivity temperature curves. The simulation results agree with experiments quantitatively, which reveal that the inhomogeneous martensitic transformation of NiTi particles is a dominant mechanism for the enlarged and nonlinearity resistivity temperature variation of the composite. Parametric studies have been conducted and the calculation results show that selecting NiTi particles with smaller particle diameter, VGCF with higher conductivity, and polymer with larger coefficient of thermal expansion is conducive to further obtain flexible composite films with better temperature sensitivity.
Targeting cancer cachexia: Molecular mechanisms and clinical study
Authors: Wang Yong‐Fei , An Zi‐Yi , Lin Dong‐Hai , Jin Wei‐Lin 
Published: September 2022

AbstractCancer cachexia is a complex systemic catabolism syndrome characterized by muscle wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer cachexia environment. During the occurrence and progression of cancer cachexia, interactions of aberrant organs with cancer cells or other organs in a cancer cachexia environment initiate a cascade of stress reactions and destroy multiple organs including the liver, heart, pancreas, intestine, brain, bone, and spleen in metabolism, neural, and immune homeostasis. The role of involved organs turned from inhibiting tumor growth into promoting cancer cachexia in cancer progression. In this review, we depicted the complicated relationship of cancer cachexia with the metabolism, neural, and immune homeostasis imbalance in multiple organs in a cancer cachexia environment and summarized the treatment progress in recent years. And we discussed the molecular mechanism and clinical study of cancer cachexia from the perspective of multiple organs metabolic, neurological, and immunological abnormalities. Updated understanding of cancer cachexia might facilitate the exploration of biomarkers and novel therapeutic targets of cancer cachexia.
Supplier encroachment and information transparency on fresh produce e‐commerce platform: Impacts on the traditional channel
Authors: Tian Yu , Dan Bin , Lei Ting , Liu Molin 
Published: September 2022

AbstractAs fresh produce e‐commerce develops, some suppliers with traditional channels begin to encroach online through agency or reselling mode of the platform. This paper studies the supplier's entry mode choice and the platform's information sharing strategy and analyzes impacts on the traditional channel. It reveals that the platform may voluntarily share information. However, increasing commission fees may inhibit the sharing motivation. The supplier may choose entry with agency selling to induce information sharing even at high commission fees. Under equilibrium strategy, the traditional channel demand and the retailer's profit may increase, indicating that supplier encroachment may achieve all‐win situation.
What drives the production and diffusion of mobile apps? An international investigation
Authors: Blanco German , Goel Rajeev K. , Ram Rati 
Published: September 2022

AbstractMobile apps have proliferated online in recent years, but related formal research has lagged behind. Using data on a large sample of nations over the years 2018–2020, we estimate the drivers of mobile app production. Results show that more mobile subscribers (capturing demand‐pull effects) increase mobile app production. However, overall E‐participation fails to exert a significant influence. Both FDI inflows and ICT imports contribute to mobile app production, as do the inputs and outputs of overall technological change (patents, researchers, and knowledge workers). These results contrast with the (mostly insignificant) results for capital formation and the rule of law.
Joint Modeling Study Identifies Blood‐Based Transcripts Link to Cognitive Decline in Parkinson's Disease
Authors: Luo Junfeng , Wu Hao , Li Jinxia , Xian Wenbiao , Li Weimin , Locascio Joseph J. , Pei Zhong , Liu Ganqiang 
Published: September 2022

AbstractBackgroundCognitive decline in Parkinson's disease (PD) is prevalent, insidious, and burdensome during the progression of the disease.ObjectivesWe aimed to find transcriptome‐wide biomarkers in blood to predict cognitive decline and identify patients at high risk with cognitive impairment in PD.MethodsWe carried out joint modeling analysis to characterize transcriptome‐wide longitudinal gene expression and its association with the progression of mild cognitive impairment (MCI) in PD patients. The average time‐dependent area under the curves (AUCs) were used for evaluating the accuracy of the significant joint models. A cognitive survival score (CogSs) derived from joint model was leveraged to predict the occurrence of MCI. All predicting models were built in a discovery cohort with 272 patients and replicated in an independent cohort with 177 patients.ResultsWe identified five longitudinal varied expression of transcripts that were significantly associated with MCI progression in patients with PD. The most significant transcript IGLC1 joint model accurately predicted the progression of MCI in PD patients in the discovery and replication cohorts (average time‐dependent AUCs >0.82). The CogSs derived from the optimal IGLC1 joint model had a high accuracy at early study stage in both cohorts (AUC ≥0.91).ConclusionsOur transcriptome‐wide joint modeling analysis uncovered five blood‐based transcripts related to cognitive decline in PD. The joint models will serve as a useful resource for clinicians and researchers to screen PD patients with high risk of development of cognitive impairment and pave the path for Parkinson's personalized medicine. © 2022 International Parkinson and Movement Disorder Society.