bluuebunny/crossref_metadata_2025_split huggingface dataset:
Availability and Advice on Test uptake: a vignette study on Covid-19 self-testing policy.
Authors: Zomer Colene , Kroese Floor , Sanders Jet , Janssen Riny , de Bruin Marijn 
Published: August 2022

Abstract
To inform future Dutch Covid-19 testing policies we did an experimental vignette study to investigate whether inclusion of the less reliable lateral flow tests (self-tests) would change test-uptake sufficiently to improve population-level test sensitivity. A representative sample (n = 3.270) participated in a 2-by-2 online experiment to evaluate the effects of test-guidelines including self-testing advice (IV1), and the effects of self-test availability (IV2) on test uptake (PCR test, self-test or no test) and sensitivity of the overall test strategy (primary outcome). Across four scenarios, changing test advice did not affect testing behaviour. Self-test availability, however, increased the timeliness of testing, the number of people testing, and overall test strategy sensitivity. Based on these findings, we recommend that (national) policy facilitates a supply of self-tests at home, for example through free and pro-active distribution of test-kits. This could substantially enhance the chances of timely detecting and isolating COVID-19 patients.
Mupirocin Blocks Imiquimod-induced Psoriasis-like skin Lesion by Inhibiting Epidermal Isoleucyl-tRNA Synthetase
Authors: Man Xiao-Yong , Yan Bing-Xi , Chen Xue-Yan , Wang Zhao-Yuan , Cui Ying-Zhe , Landeck Lilla , Fu Ni-Chang , Yang Xing-Yu , Xu Fan , Zhou Yuan , Chen Jia-Qi 
Published: August 2022

Abstract
Background: The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed to investigate the mechanisms underlying the efficacy of IARS inhibitor, mupirocin, treatment for psoriasis.Methods: The expression of IARS was determined by immunofluorescence, Western blot and qRT-PCR in normalhealthy control- and psoriatic human skin. An imiquimod（IMQ）-induced psoriasis-like skin disease model was used to study the phenotypes changed by an IARS inhibitor, mupirocin (MUP). Endotypes were analyzed by RNA-seq, R&D Luminex multi-factor technique, ELISA, immunofluorescence and flow cytometry. Additionally, the effect of MUP on epidermal keratinocytes (KCs) were conducted in-vitro in primary cultured human KCs.Results: We found the expression of IARS was higher in psoriatic skin than in healthy controls. In IMQ-induced psoriasis-like C57BL/6 mouse model, MUP reversed IMQ-induced keratinocytes proliferation, expression of inflammatory cytokines and infiltration of immune cells. Furthermore, in cultured human keratinocytes, MUP inhibited proliferation, but promoted apoptosis, which may be related with STAT3 signaling pathway. Conclusion: Our finding of blocking the infiltration of immune cells by inhibiting the formation of IARS, could be one mechanism to explain the effect of MUP in the treatment of psoriasis. Developing strategies targeting suppression IARS should open new perspectives for the treatment of psoriasis.
Evaluation of Efficacy &amp; Safety of Isotine Plus I Drops in Patients suffering from Immature Uncomplicated Cataract - An Open Labeled, Comparative, Multi-centric, Two Arm, Prospective, Interventional Clinical Study
Authors: Tamoli Sanjay , Agiwal Sachin , Bagde Sachin , Ingle Pushpalata , Pande Shishir , Bhandary Sapna , Ghedge Gayatri , Kalkaru Rashmi 
Published: August 2022

Abstract
Background
Cataract is one of the commonest ocular disorders in elderly population and major cause of blindness. Natural compounds consisting of antioxidant and anti-inflammatory phytoconstituents can serve as probable leads for anticataract agents.The ingredients present in the Isotine Pus I drops may help in improving vision and delay progression of cataract.
Hypothesis/Purpose:
The present clinical study was conducted to evaluate efficacy and safety of Isotine Plus I Drops in patients suffering from immature uncomplicated cataract.
Methods
This open label, comparative, multicentric, two arm, prospective, interventional clinical study was carried out at three study centres.A total of 69 subjects were enrolled in the study of which there were 61 completers – 30 in Isotine group and 31 in control group.Subjects in Isotine group were instructed to use 2 drops in each eye twice daily for a period of 6 months (180 days), while subjects in control group were instructed to continue the conventional treatment, which they were already taking as prescribed by ophthalmologist. The study involved the use of slit lamp microscopic examination in tangential sectioning of lens and retro-illumination technique for grading of cataract and other scales for overall change and safety.
Results
With a treatment of six months, a statistically significant higher number of subjects showed improvement in Isotine Plus I drop group as compared to the conventional treatment group as observed with slit lamp and opthalmic examinations. Various scales used in the study to evaluate the extent of cataract and vision showed that with the use of Isotine Plus I drops there was a significant difference in cataract condition. Isotine Plus I Drops was found to be safe on regular long-term use without producing any adverse effects.
Conclusion
Regular use of Isotine Plus I Drops in a dose of 2 drops twice daily for a period of 6 months helps in arresting the progression and thus management of cataract.
Stability Analysis of Rock-Socketed Piles on Inclined Slope: Case Study on Conveyor Belt Foundations of Dangote Cement, Ethiopia
Authors: Dadi Oliyad Megersa , Chala Endalu Tadele 
Published: August 2022

Abstract
This study was carried out the stability analysis of rock-socketed pile on inclined slope at Dangote Cement (Ethiopia) around C1-12A, C1-13A and C1-14A Conveyor Belt foundation. The Conveyor foundations were founded on the natural inclined slope which passes through rugged topography and faces frequent slope stability problems. The study identified and analyzed the stability of slope by determining the geological and geotechnical properties of materials which compose the critical slope section. Detailed field work was done to collect a sample for laboratory tests such as moisture content, grain size analysis, Atterberg limit, compaction test and direct shear test. Based on the field manifestations and secondary data from different sources the critical slope section was identified for stability analyses. The slope stability analysis was made by three-dimensional finite element method, Rocscience based RS3 software. The slope stability analyses in terms of safety factor for both dry and saturated condition were analyzed. The analyzed results showed that, for saturated conveyor belt with rock-socketed pile, the factor of safety was 1.648 and stable. Even though, the factor of safety was stable, it was deducted from 3.698 for dry condition to 1.648 for saturated condition. Therefore, the stability of rock-socketed pile on inclined slope was highly depending on the raising of ground water table in the rainy season. Based on the identified slope stability governing factors, the proper drainage system such as surface drainage (i.e. furrows and ditches) which can prevent infiltration of rainfall and flood into the slope and subsurface drainage (i.e. horizontal and inclined drain pipe) which reduce the raising of groundwater was recommended. The stability of pile foundation in terms of bearing capacity, settlement, lateral resistance and pull-out capacity of grouped pile were analyzed using RSPile software and hand calculations. The analyzed results showed that, the pile foundation was safe against bearing capacity and uplift failure. The maximum displacement of grouped pile was less than the maximum permissible displacement and the maximum lateral deflection was less than the permissible lateral deflection allowed for grouped pile.
LINC00520 promotes breast cancer development by low expression as a tumor suppressor and prognostic biomarker by regulating the ESR2 expression level: integrated systems biology bioinformatics and experimental analyses
Authors: Ezzati Ehsan , Mosadeghi Safiye , Akbarinia Aliasghar , Horriat Soroor , Rezaei Mohammad , Azadeh Mansoureh 
Published: August 2022

Abstract
Background
ESR2 can have a remarkable effect on the proliferation and tumorigenesis of breast cancer (BC) as a hub tumor suppressor by regulating the effect of estrogen. The abnormal changes in the expression of the co-expressed lncRNAs can have a regulatory effect on the ESR2 expression and cause BC status. In this research, the expression and correlation of ESR2 and a related lncRNA (LINC00520) were examined through different statistical methods.
Method
An integrated bioinformatics analysis was performed to obtain a reasonable prediction about the relation of potential biomarkers and design an experiment. Based on the Microarray data analysis, pathway enrichment, GO, and ceRNA interaction analyses, a collection of RNAs was selected for the real-time PCR experiment. Several statistical methods were performed to evaluate the difference in the expressions in the BC samples, correlation of RNAs, and the possibility of being prognostic and diagnostic biomarkers (ROC and clinicopathological analysis).
Result
It is demonstrated that ESR2 (logFC: -1.842, P. Value < 0.0001) and LINC00520 (logFC: -2.231, P. Value < 0.0001) are the two robust breast cancer potential tumor suppressor in BC population. Likewise, it is demonstrated that the expression of these two RNAs has a significantly positive correlation in tumor samples (r: 0.7, P. Value: 0.0008). ESR2 (AUC: 0.9775, P. Value < 0.0001) and LINC00520 (AUC: 0.8450, P. Value: 0.0002) are the two potential diagnostic biomarkers of BC. Furthermore, expression of LINC00520 has a significant correlation with the stage (stage II) and tumor size (less than 5 cm) in the BC patients.
Conclusion
It is highly possible that the abnormal changes in the expression of LINC00520 can significantly help BC development by affecting the expression of ESR2 and playing a tumor suppressor role in Isfahan BC population. Furthermore, LINC00520 could be considered as a significant prognostic (clinicopathological analysis) and diagnostic (ROC analysis) biomarkers of BC.
Analysis of the Curative Effect and Survival Difference of Three Different Surgical Methods for Bladder Cancer Patients with Radical Cystectomy and Ureterostomy
Authors: Ma Qiyue , Yang Xiaoming , Yang Yang , Yi Chengzhi , Wei Xiaosong , Fang Zhiwei , Song Dongkui 
Published: August 2022

Abstract
Background: Bladder cancer is one of the most common urinary tract tumors. At present, for the treatment of invasive muscular bladder cancer or high-risk non-invasive muscular bladder cancer, radical cystectomy, urinary diversion and pelvic lymph node dissection are the preferred methods. Ureterostomy is one of the commonly used surgical procedures for postoperative urinary diversion. Open radical cystectomy (ORC), laparoscopic radical cystectomy (LRC) and robot-assisted laparoscopic radical cystectomy (RARC) are common radical cystectomy methods commonly used by urologists. Methods: In this study, patients with bladder cancer were treated with 3 different surgical methods, and the postoperative efficacy was compared, and the survival difference was analyzed. Results: Our results showed that LRC and RARC were significantly superior to ORC in intraoperative and perioperative observation indexes, and LRC and RARC could more completely remove tumors compared with ORC in complex cases. However, the survival time after ORC was longer than that of LRC and RARC patients. Conclusion: Operation methods, tumor staging, pathological grade, and number of lymph nodes dissected are all independent factors affecting patient survival, which should be paid more attention to clinically.
Issues of therapy for post-acne post-inflammatory hyperpigmentation
Authors: Kruglova L. S. , Gryazeva N. V. 
Published: August 2022

Introduction. Post-acne post-inflammatory hyperpigmentation most often develops in patients with moderate to severe acne. Post-acne pigmentation can be persistent and last from months to several years, which has a negative impact on the patients’ quality of life. It occurs at any age with the same frequency in men and women.Aim. To evaluate the effect of dermatocosmetic products – a triple effect serum (containing thiamidol, salicylic acid and lycochalcone A) and SPF30 fluid for problematic skin on the skin condition in patients with moderate and severe post-acne post-inflammatory hyperpigmentation.Material and methods. A total of 57 patients with post-acne post-inflammatory hyperpigmentation localized on the facial skin were under observation. The age of the patients was 22.4 ± 2.7 years. 32 patients were diagnosed with mild post-acne PIH, 25 patients – with moderate post-acne PIH. All patients used dermocosmetic products such as the triple effect serum (containing thiamidol, salicylic acid and lycochalcone A) and SPF30 fluid for problematic skin. Efficacy was evaluated with due account for mexametry findings, GSS, dermatology life quality index. Digital data were processed using standard medical statistical methods: calculation of the arithmetic mean value (X), square deviation (σ), Student’s t-test (t).Results. After 12 weeks the mexometric index decreased: 92.7 and 85.9% in mild and moderate post-acne PIH, respectively. The DLQ index reduced by 84.9 and 83.8% by the end of the treatment,Conclusions. The use of innovative dermocosmetic products containing salicylic acid and licochalcon A effectively reduces post-acne pigmentation. All patients noted good organoleptic properties: skin application comfort and excellent tolerability of the products.
Argumentasi Pembaruan Ushul Al-Fiqh: Problematika dan Tantangannya
Authors: Hidayat Muhammad Syarif 
Published: August 2022

AbstrakPembaruan atas hukum Islam meliputi pembaruan atas Ushūl al-Fiqh dan Fiqh. Ushūl al-Fiqh khususnya sebagai metode pengabilan hukum Islam merupakan salah satu yang paling disorot. Seiring dengan perkembangan zaman, Ushūl al-Fiqh dituntut peranannya untuk selalu luwes dan tanggap dalam merespon problematika umat. Oleh karena itu, secara tidak langsung, pembaruan Ushūl al-Fiqh merupakan hal yang tidak bisa dielakkan. Namun demikian, usaha untuk melakukan pembaruan mendapat respon beragam dari berbagai kalangan. Ada yang pro juga ada yang kontra. Tulisan ini adalah sebuah upaya untuk mendeskripsikan pembaruan yang terjadi dalam Ushūl al-Fiqh dengan menampilkan beberapa argumen dari para pemikir klasik maupun kontemporer. Tulisan ini merupakan studi kepustakaan dan dianalisis dengan metode deskriptif-analitik.Kata Kunci: Pembaruan, Ushūl al-Fiqh, Hukum Islam AbstractRenewal of Islamic law includes renewal of Ushūl al-Fiqh and Fiqh. Ushul al-Fiqh in particular as a method of imposing Islamic law is one of the most highlighted. Along with the times, Ushul al-Fiqh is required to have a role to always be flexible and responsive in responding to the problems of the people. Therefore, indirectly, the renewal of Ushūl al-Fiqh is inevitable. However, efforts to carry out reform have received mixed responses from various groups. There are pros and cons. This paper is an attempt to describe the reforms that have occurred in Ushūl al-Fiqh by presenting several arguments from classical and contemporary thinkers. This paper is a literature study and is analyzed using descriptive-analytic methods.Keywords: renewal, Ushūl al-Fiqh, Islamic Law
The analysis of Reservoar Porosity Calculation based on Well Log in Bintuni Basin Area
Authors: Suwondo Suwondo , Utomo Warto , Zera Tati , Almuqtadir Muhammad Thariq 
Published: August 2022

The Bintuni Basin is one of several oil and gas producing basin in Eastern Indonesia. This basin has one of the hydrocarbon-producing reservoir in the Kais Formation. The carbonate reservoir in Kais Formation is Middle to Upper Miocene age. The understanding of reservoirs is important for further field development. Petrophysical analysis is a method for understanding reservoirs especially porosity parameter and estimation of hydrocarbon reserve. The data used in study is well data including, mudlog report, well report, Gamma Ray (GR), Sonic, Resistivity (ILD, ILS, MSFL), density (RHOB) and NPHI logs. The aim study is to analyze the reservoir using Gamma Ray log and porosity calculation using Sonic, RHOB and NPHI logs. The study method includes regional geological literature review, marker analysis, Gamma Ray picking, and reservoir porosity calculations. According to Gamma Ray picking analysis, the Kais Formation GR has values of GRsand = 25 API and values of GRshale = 80 API. The Low Gamma Ray below 60 API is interpretated as carbonate reservoir. For porosity validation, the porosity of routine core analysis (RCAL) data is plotted into porosity logs (porosity calculation using Sonic, RHOB and NPHI logs). Based on the porosity calculation using three porosity logs(Sonic, Density, NPHI Logs), the porosity estimated from density log is more match with the porosity of routine core analysis (RCAL) data. According to porosity calculation at WTU Well, the porosity from log density in the Kais Formation has value from 2% - 25%. The porosity in Carbonate has large value as a result of secondary porosity.©2022 JNSMR UIN Walisongo. All rights reserved.
The first detection of SARS-CoV-2 RNA in urban wastewater in Giza, Egypt
Authors: Shaheen Mohamed N. F. , Elmahdy Elmahdy M. , Shahein Yasser E. 
Published: August 2022

Abstract
The new coronavirus (SARS-CoV-2) is a respiratory virus causing coronavirus disease (COVID-19). Individuals with COVID-19 can shed the viral genome in their feces, even if they do not have symptoms, and the virus can be detected in wastewater. The current study provides the first surveillance of SARS-CoV-2 RNA genome in the wastewater in Egypt. To study this aim, untreated influent (n = 48) and treated effluent (n = 48) samples were collected between January and December 2021 from the wastewater treatment plant in Giza. The viral RNA genome was determined by reverse transcription-polymerase chain reaction (RT-PCR) (S, E, and N target regions) and real-time quantitative reverse transcription-PCR (RT-qPCR) (N1 and N2 target regions). The RT-PCR assay failed to detect SARS-CoV-2 RNA in all samples analyzed, whereas RT-qPCR succeeded in the detection of N gene of SARS-CoV-2 in 62.5% of untreated influent samples. The RT-qPCR Ct values of those samples tested positive ranged from 19.9 to 30.1 with a mean of 23. The treated effluent samples were negative for viral RNA detected by both RT-PCR and RT-qPCR, indicating the efficiency of the sewage treatment plant in degrading SARS-CoV-2. Our preliminary findings provide evidence for the value of wastewater epidemiology approach for the surveillance of SARS-CoV-2 in the population to assist in the responses of public health to COVID-19 outbreak.
Estimating the economic impact of large hydropower projects: a dynamic multi-regional computable general equilibrium analysis
Authors: Ni Hongzhen , Zhao Jing , Peng Xiujian , Chen Genfa 
Published: August 2022

AbstractIn response to rapidly growing energy demands, Chinese authorities plan to invest more in hydropower development. However, there are concerns about the possible effects on macroeconomy. This paper uses SinoTERM, a dynamic multi-regional computable general equilibrium model (CGE) of the Chinese economy, to analyze the economic impact of large hydropower development projects. The model features regional labor market dynamics and an electricity subdivision module with substitutability between various types of electricity generation. The results suggest that hydropower development will boost economic growth in the project region. Most sectors in the project region will benefit from the hydropower development such as other services, health, and education, while some sectors will suffer a loss in output because of the substantial increase in real wages. For the national, every 10,000 yuan investment can drive the national GDP growth of 1,000 yuan, and the cost is expected to be recovered in ten years. By the end of 2040, the real national wage will be around 0.16% higher than the baseline scenario. The project could only be justified if net environmental benefits outweigh this loss.
Multisystem Inflammatory Syndrome in a Newborn (MIS-N): Clinical
Evidence and Neurodevelopmental Outcome
Authors: Sinaei Reza , Jamali Zahra , Razi Leyla 
Published: August 2022

Background:
Although coronavirus disease-2019 (COVID-19) seems to be milder in children than in adults, children may exhibit severe multisystemic involvement, supported by grow-ing evidence of this incidence in neonates. This case report aimed to demonstrate an inflammatory response syndrome in a full-term neonate - born from a 35-dlo raey woman infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Case presentation:
A full-term neonate girl with uneventful perinatal history was admitted with mild tachypnea at the first hour of birth and gradually worsened, resulting in subsequent ventilator support on the second day. The nasal SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test was positive in several cessations from the time of admission until the tenth day. She revealed cardiomegaly, a diffuse opacification of lungs in the chest radiograph, both side ventricular hyper-trophy, valvular regurgitation, and severe pulmonary hypertension on echocardiography. She un-derwent treatment with surfactant, antibiotics, paracetamol, inotropes, and sildenafil, with beneficial effects. In the lack of a positive fluid culture, she developed necrotizing enterocolitis, transaminitis, and a generalized rash on day six. Furthermore, her mild brain edema that occurred on the second day developed into hydrocephaly. The patient was considered MIS-N and successfully treated with methylprednisolone pulse and intravenous immunoglobulin. She was discharged after 29 days and followed for eight months with persistent mild hydrocephalous and possible evidence of cerebral palsy.

Conclusions:
We conclude that maternal exposure to COVID-19 may potentially be associated with multisystem inflammation in the early neonatal period. However, this condition is relatively rare. Immunomodulatory agents may be beneficial in this condition.
The Emerging Omicron Variant, Children and School
Authors: Ha Jennifer F. 
Published: August 2022

Abstract:
Many publications have demonstrated the detrimental effects of school closures on children, families and communities in the past two years of the COVID-19 pandemic. Currently, there is a surge of Omicron cases as children prepare to return to school around the world. While many children are asymptomatic, or have mild disease, it is nevertheless and important problem. As we focus on vaccinations in the 5–12-year-old group, we should consider other risk mitigation factors to keep school open, and children safe.