bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I Beat Cancer to Feel Sick:” Qualitative Experiences of Sleep Disturbance in Black Breast Cancer Survivors and Recommendations for Culturally Targeted Sleep Interventions
Authors: Geiss Carley , Chavez Melody N , Oswald Laura B , Ketcher Dana , Reblin Maija , Bandera Elisa V , Savard Josée , Zhou Eric S , Fox Rina S , Jim Heather S L , Gonzalez Brian D 
Published: June 2022

Abstract

Background
Sleep disturbance is common and distressing among cancer survivors. Black breast cancer survivors (BBCS) suffer disproportionately from sleep disturbance, yet there is limited research on how to address this issue.

Purpose
This study aimed to understand the multifaceted experiences of sleep disturbance among BBCS and how to culturally target a mobile health (mHealth) intervention to improve sleep outcomes in BBCS.

Methods
Semi-structured interviews were conducted in a purposive sample of 10 BBCS. Interviews were audio-recorded, transcribed, and coded for key barriers to sleep and potential solutions to incorporate into behavioral interventions using NVivo 12. Inductive applied thematic analysis techniques were employed to identify emergent themes.

Results
Ten BBCS (mean age = 54, SD = 10) described their experiences of sleep disturbance with themes including: (1) barriers to quality sleep (e.g., cancer worry, personal responsibilities), (2) psychosocial impacts of sleep disturbance (e.g., fatigue, distress), and (3) commonly used strategies to improve sleep. The second section discusses suggestions for developing mHealth interventions to improve sleep for BBCS including: (1) feedback on an existing mHealth intervention and (2) intervention topics suggested by BBCS.

Conclusions
Our findings highlight the challenges associated with sleep disturbance in BBCS. Participants report culturally targeted mHealth interventions are needed for BBCS who experience chronic sleep disturbance that affects their overall quality of life. These interventions should address coping with sleep-related issues relevant to many breast cancer survivors and BBCS (e.g., sexual intimacy, fear of cancer recurrence) and should incorporate intervention strategies acceptable to BBCS (e.g., prayer, meditation).
Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March–April 2021
Authors: Moline Heidi L , Keaton Amelia , Rice Whitney , Varghese Jasmine , Deng Li , Waters Ansley , Barringer Anna , Winston Devonne , Fields Virgie , Slifka Kara Jacobs , Verani Jennifer R , Schrag Stephanie J , Jernigan John , Tate Jacqueline E , Fleming-Dutra Katherine E 
Published: June 2022

Abstract
In April 2021, we assessed mRNA vaccine effectiveness (VE) in the context of a COVID-19 outbreak in a skilled nursing facility. Among 28 cases, genomic sequencing was performed on 4 specimens on 4 different patients, and all were classified by sequence analysis as the Beta (B.1.351) variant. Adjusted VE among residents was 65% (95% confidence interval: 25–84%). These findings underscore the importance of vaccination for prevention of COVID-19 in skilled nursing facilities.
Development and validation of a molecular tool to predict pathologic complete response in esophageal adenocarcinoma
Authors: Qian David C , Lefferts Joel A , Zaki Bassem I , Brickley Elizabeth B , Jackson Christopher R , Andrici Juliana , Sriharan Aravindhan , Lisovsky Mikhail 
Published: June 2022

AbstractPathologic complete response (pCR) to neoadjuvant chemoradiation for locally advanced esophageal adenocarcinoma (EAC) confers significantly improved survival. The ability to infer pCR may spare esophagectomy in some patients. Currently, there are no validated biomarkers of pCR. This study sought to evaluate whether a distinct signature of DNA copy number alterations (CNA) can be predictive of pCR in EAC. Pretreatment biopsies from 38 patients with locally advanced EAC (19 with pCR and 19 with pathologic partial/poor response) were assessed for CNA using OncoScan assay. A novel technique was employed where within every cytogenetic band, the quantity of bases gained by each sample was computed as the sum of gained genomic segment lengths weighted by the surplus copy number of each segment. A threefold cross-validation was used to assess association with pCR or pathologic partial/poor response. Forty patients with locally advanced EAC from The Cancer Genome Atlas (TCGA) constituted an independent validation cohort. Gains in the chromosomal loci 14q11 and 17p11 were preferentially associated with pCR. Average area under the receiver operating characteristic curve (AUC) for predicting pCR was 0.80 among the threefold cross-validation test sets. Using 0.3 megabases as the cutoff that optimizes trade-off between sensitivity (63%) and specificity (89%) in the discovery cohort, similar prediction performance for clinical and radiographic response was demonstrated in the validation cohort from TCGA (sensitivity 61%, specificity 82%). Copy number gains in the 14q11 and 17p11 loci may be useful for prediction of pCR, and, potentially, personalization of esophagectomy in EAC.
Robotic versus thoraco-laparoscopic minimally invasive Ivor Lewis esophagectomy, a matched-pair single-center cohort analysis
Authors: Chouliaras Konstantinos , Attwood Kristopher , Brady Maureen , Takahashi Hideo , Peng June S , Yendamuri Sai , Demmy Todd L , Hochwald Steven N , Kukar Moshim 
Published: June 2022

Abstract
Minimally invasive esophagectomy (MIE) is becoming more widespread with a documented improvement in postoperative morbidity based on level I evidence. However, there is a lack of consensus regarding the optimal MIE approach, conventional thoracoscopy/laparoscopy vs robotics as well as the ideal anastomotic technique. All patients who underwent MIE via an Ivor Lewis approach with a side-to-side stapled anastomosis were included. The thoracoscopy-laparoscopy (TL) group was compared to the robotic group with respect to perioperative outcomes using the entire cohorts and after 1:1 propensity score matching. Comparisons were made using the Mann–Whitney U and Fisher’s exact tests. Between July 2013 and November 2020, 72 TL and 67 robotic Ivor Lewis MIE were performed. After comparing the two unadjusted cohorts and 51 propensity matched pairs, there was a decrease in Clavien-Dindo Grade 2 or above complications in the robotic vs TL group (59.7% vs 41.8% [P = 0.042], (62.7% vs 39.2% [P = 0.029]), respectively. In both analyses, there was a reduction in hospital length of stay (median of 8 vs 7 days, P &lt; 0.001) and a trend toward less anastomotic leaks in the robotic group (Unadjusted: 12.5 vs 3% [P = 0.057], Propensity-matched analysis: 13.7% vs 3.9% [P = 0.16]), respectively. A clinically significant decrease in overall morbidity, cardiac complications and hospital length of stay was observed in the robotic Ivor Lewis cohort when compared with the TL group at a high volume MIE program. Side-to-side stapled thoracic anastomoses utilizing a robotic platform provides the best outcomes in this single institution experience.
Moth-eaten like impact of automated titanium fasteners on aortic valve bioprosthesis: a word of caution
Authors: Santer David , Miazza Jules , Eckstein Friedrich 
Published: June 2022

Abstract
A 78-year-old patient underwent his third biological aortic valve replacement (25 mm, Inspiris Resilia™, Edwards Lifesciences LLC, Irvine, CA, USA) with COR-KNOT® (LSI Solutions, Victor, NY, USA) due to valve degeneration in 2018 at a foreign hospital. In 2021, the patient was diagnosed with severe aortic regurgitation and admitted to our hospital for his fourth surgery. Intraoperatively, a total of 7 perforations in all 3 valve leaflets have been observed, which were obviously induced by the rigid metallic fasteners. Redo isolated aortic valve replacement (29 mm, Perimount Magna Ease, Edwards Lifesciences LLC) was performed with conventionally knotted, pledget enforced braided threads. Postoperative course was uneventful. This report shows that COR-KNOT-induced defects do not appear immediately after surgery but within the first 4 postoperative months. Since failure of aortic bioprostheses due to aortic insufficiency is often rated as ‘early degeneration’ and degenerated aortic bioprostheses are mostly replaced by valve-in-valve strategy, the true incidence of this serious complication might be underestimated. COR-KNOT should be used with caution in biological aortic valve replacement and patients should undergo close postoperative follow-ups.
Estimating decay curves of neutralizing antibodies to SARS-CoV-2 infection
Authors: Poehler Elliot , Gibson Liam , Lustig Audrey , Moreland Nicole J , McGregor Reuben , James Alex 
Published: June 2022

Abstract
Estimating the longevity of an individual’s immune response to the SARS-Cov-2 virus is vital for future planning, particularly of vaccine requirements. Neutralizing antibodies (Nabs) are increasingly being recognized as a correlate of protection and while there are many studies that follow the response of a cohort of people, each study alone is not enough to predict the long-term response. Studies use different assays to measure Nabs, making them hard to combine. We present a modelling method that can combine multiple datasets and can be updated as more detailed data becomes available. Combining data from seven published datasets we predict that the NAb decay has two phases, an initial fast but short-lived decay period followed by a longer term and slower decay period.
Analysis of the HIV Vaccine Trials Network 702 Phase 2b–3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T-Cell Correlates of HIV-1 Acquisition Risk
Authors: Moodie Zoe , Dintwe One , Sawant Sheetal , Grove Doug , Huang Yunda , Janes Holly , Heptinstall Jack , Omar Faatima Laher , Cohen Kristen , De Rosa Stephen C , Zhang Lu , Yates Nicole L , Sarzotti-Kelsoe Marcella , Seaton Kelly E , Laher Fatima , Bekker Linda Gail , Malahleha Mookho , Innes Craig , Kassim Sheetal , Naicker Nivashnee , Govender Vaneshree , Sebe Modulakgotla , Singh Nishanta , Kotze Philip , Lazarus Erica , Nchabeleng Maphoshane , Ward Amy M , Brumskine William , Dubula Thozama , Randhawa April K , Grunenberg Nicole , Hural John , Kee Jia Jin , Benkeser David , Jin Yutong , Carpp Lindsay N , Allen Mary , D’Souza Patricia , Tartaglia James , DiazGranados Carlos A , Koutsoukos Marguerite , Gilbert Peter B , Kublin James G , Corey Lawrence , Andersen-Nissen Erica , Gray Glenda E , Tomaras Georgia D , McElrath M Juliana 
Published: June 2022

AbstractBackgroundThe ALVAC/gp120 + MF59 vaccines in the HIV Vaccine Trials Network (HVTN) 702 efficacy trial did not prevent human immunodeficiency virus-1 (HIV-1) acquisition. Vaccine-matched immunological endpoints that were correlates of HIV-1 acquisition risk in RV144 were measured in HVTN 702 and evaluated as correlates of HIV-1 acquisition.MethodsAmong 1893 HVTN 702 female vaccinees, 60 HIV-1–seropositive cases and 60 matched seronegative noncases were sampled. HIV-specific CD4+ T-cell and binding antibody responses were measured 2 weeks after fourth and fifth immunizations. Cox proportional hazards models assessed prespecified responses as predictors of HIV-1 acquisition.ResultsThe HVTN 702 Env-specific CD4+ T-cell response rate was significantly higher than in RV144 (63% vs 40%, P = .03) with significantly lower IgG binding antibody response rate and magnitude to 1086.C V1V2 (67% vs 100%, P &lt; .001; Pmag &lt; .001). Although no significant univariate associations were observed between any T-cell or binding antibody response and HIV-1 acquisition, significant interactions were observed (multiplicity-adjusted P ≤.03). Among vaccinees with high IgG A244 V1V2 binding antibody responses, vaccine-matched CD4+ T-cell endpoints associated with decreased HIV-1 acquisition (estimated hazard ratios = 0.40–0.49 per 1-SD increase in CD4+ T-cell endpoint).ConclusionsHVTN 702 and RV144 had distinct immunogenicity profiles. However, both identified significant correlations (univariate or interaction) for IgG V1V2 and polyfunctional CD4+ T cells with HIV-1 acquisition.Clinical Trials Registration . NCT02968849.
HIV Treatment Outcomes in POP-UP: Drop-in HIV Primary Care Model for People Experiencing Homelessness
Authors: Hickey Matthew D , Imbert Elizabeth , Appa Ayesha , Del Rosario Jan Bing , Lynch Elizabeth , Friend John , Avila Rodrigo , Clemenzi-Allen Angelo , Riley Elise D , Gandhi Monica , Havlir Diane V 
Published: June 2022

Abstract

Background
People with HIV experiencing homelessness have low rates of viral suppression, driven by sociostructural barriers and traditional care system limitations. Informed by the capability-opportunity-motivation-behavior (COM-B) model and patient preference research, we developed POP-UP, an integrated drop-in (nonappointment-based) HIV clinic with wrap-around services for persons with housing instability and viral nonsuppression in San Francisco.

Methods
We report HIV viral suppression (VS; &lt;200 copies/mL), care engagement, and mortality at 12 months postenrollment. We used logistic regression to determine participant characteristics associated with VS.

Results
We enrolled 112 patients with viral nonsuppression and housing instability: 52% experiencing street-homelessness, 100% with a substance use disorder, and 70% with mental health diagnoses. At 12 months postenrollment, 70% had ≥1 visit each 4-month period, although 59% had a 90-day care gap; 44% had VS, 24% had viral nonsuppression, 23% missing, and 9% died (6 overdose, 2 AIDS-associated, 2 other). No baseline characteristics were associated with VS.

Conclusions
The POP-UP low-barrier HIV care model successfully reached and retained some of our clinic’s highest-risk patients. It was associated with VS improvement from 0% at baseline to 44% at 12 months among people with housing instability. Care gaps and high mortality from overdose remain major challenges to achieving optimal HIV treatment outcomes in this population.
NIRS3 spectral analysis of the artificial Omusubi-Kororin crater on Ryugu
Authors: Galiano A , Palomba E , Dirri F , Longobardo A , Kitazato K , Iwata T , Matsuoka M , Hiroi T , Takir D , Nakamura T , Abe M , Ohtake M , Matsuura S , Watanabe S , Yoshikawa M , Saiki T , Tanaka S , Okada T , Yamamoto Y , Takei Y , Shirai K , Hirata N , Matsumoto K , Tsuda Y 
Published: June 2022

ABSTRACT
The JAXA Hayabusa2 mission accomplished the formation of an artificial crater on the asteroid Ryugu. The aim of this work is to analyse the area surrounding the artificial crater and reveal spectral variability compared to the same region before the crater formation, to mineralogically and physically characterize the subsurface exposed material. The crater’s investigation focused on the analysis of two regions corresponding to the inner part of crater (the pit and the crater wall/floor), two areas related to ejecta deposited close to the crater, two areas of ejecta moved far from the crater, and two external areas. Each area was investigated both before and after the crater formation, by the study of the photometrically corrected spectral parameters: the 1.9 $\mu$m reflectance, the near-infrared spectral slope, and the depth of the bands at 2.7 and 2.8 $\mu$m. The subsurface material of the post-crater areas shows deeper absorption bands, a decrease in reflectance, and a reddening in spectral slope with respect to the surface material of pre-crater areas. The subsurface regolith could have experienced a lower OH devolatilization due to space weathering and/or could be composed of finer dark grains than the surface layer. The ejecta reached distances of $\sim $20 m from the impact point, mainly moving in the northern direction; nevertheless, a few ejecta also reached the south-eastern part of crater.
Superresolution trends in the ALMA Taurus survey: structured inner discs and compact discs
Authors: Jennings Jeff , Tazzari Marco , Clarke Cathie J , Booth Richard A , Rosotti Giovanni P 
Published: June 2022

ABSTRACT
The 1.33-mm survey of protoplanetary discs in the Taurus molecular cloud found annular gaps and rings to be common in extended sources (≳ 55au), when their 1D visibility distributions were fit parametrically. We first demonstrate the advantages and limitations of non-parametric visibility fits for data at the survey’s 0.12-arcsec resolution. Then we use the non-parametric model in Frankenstein (frank) to identify new substructure in three compact and seven extended sources. Among the new features, we identify three trends: a higher occurrence rate of substructure in the survey’s compact discs than previously seen, underresolved (potentially azimuthally asymmetric) substructure in the innermost disc of extended sources, and a ‘shoulder’ on the trailing edge of a ring in discs with strong depletion at small radii. Noting the shoulder morphology is present in multiple discs observed at higher resolution, we postulate it is tracing a common physical mechanism. We further demonstrate how a superresolution frank brightness profile is useful in motivating an accurate parametric model, using the highly structured source DL Tau in which frank finds two new rings. Finally, we show that sparse (u, v) plane sampling may be masking the presence of substructure in several additional compact survey sources.
A large range of haziness conditions in hot-Jupiter atmospheres
Authors: Arfaux Anthony , Lavvas Panayotis 
Published: June 2022

ABSTRACT
We present a study of photochemical hazes of exoplanet atmospheres based on a self-consistent model including haze microphysics, disequilibrium chemistry, and radiative feedbacks. We derive the haze properties required to match Hubble Space Telescope observations of 10 hot-Jupiters. HAT-P-12b, HD-189733b, HD-209458b, and WASP-6b require haze mass fluxes between 5 × 10−15 and 9 × 10−12 g cm−2 s−1 to match the observations. WASP-12b and WASP-19b with equilibrium temperatures above 2000 K are incompatible with the presence of haze and are better fitted by heavy metals. HAT-P-1b and WASP-31b do not show clear evidence for the presence of hazes with upper mass fluxes of 10−15 and 10−16 g cm−2 s−1, respectively, while WASP-17b and WASP-39b present an upper mass flux limit of 10−16 g cm−2 s−1. We discuss the implications of the self-consistent model and we derive upper limits for the haze abundances based on photochemistry results. Our results suggest HCN as the main haze precursor up to 1300 K effective temperatures and CO above. Our derived haze mass fluxes based on the fit to the observations are consistent with the photochemistry with formation yields up to ∼6.4 per cent. Disequilibrium chemistry has negligible impact on the spectra considering the low-resolution observations used but impacts the chemical composition and temperature profiles. We find that hazes produce hotter upper atmosphere temperatures with a detectable impact on the spectra. Clouds may have implications for interpreting the transit spectra of HD-209458b, WASP-31b, and WASP-39b. Nevertheless, the presence of silicate and iron clouds is expected in all studied atmospheres except WASP-12b and WASP-19b.
Bias on tensor-to-scalar ratio inference with estimated covariance matrices
Authors: Beck Dominic , Cukierman Ari , Wu W L Kimmy 
Published: June 2022

ABSTRACT
We investigate simulation-based bandpower covariance matrices commonly used in cosmological parameter inferences such as the estimation of the tensor-to-scalar ratio r. We find that upper limits on r can be biased low by tens of per cent. The underestimation of the upper limit is most severe when the number of simulation realizations is similar to the number of observables. Convergence of the covariance-matrix estimation can require a number of simulations an order of magnitude larger than the number of observables, which could mean $\mathcal {O}(10\ 000)$ simulations. This is found to be caused by an additional scatter in the posterior probability of r due to Monte Carlo noise in the estimated bandpower covariance matrix, in particular, by spurious non-zero off-diagonal elements. We show that matrix conditioning can be a viable mitigation strategy in the case that legitimate covariance assumptions can be made.
Early pregnancy human decidua gamma/delta T cells exhibit tissue resident and specific functional characteristics
Authors: Yang Shuo , Feng Ting , Ma ChengYong , Wang Tiehao , Chen Hongqin , Li Liman , Liu Yuan , Zhou Bin , Zhou Rong , Li Hong 
Published: June 2022

AbstractA successful pregnancy is a complicated process that builds upon two aspects of the maternal immune system that need to be balanced. As one of the indispensable groups of immune cell at the maternal–fetal interface, the decidual gamma/delta (γδ) T cells have attracted research attention in normal pregnancy and miscarriage. However, the role of γδ T cells in fetal growth remains poorly understood. Here, we found that the γδ T-cell population resident in decidua during early pregnancy was enriched and secreted growth factors including growth differentiation factor 15 and bone morphogenetic protein 1. A diminution in such growth factors may impair fetal development and result in fetal growth restriction. We also observed that early decidual γδ T cells exhibited stronger cytokine-secretion characteristics, but that their cytotoxic actions against A549 cells were weaker, compared with γδ T cells in peripheral blood mononuclear cells (PBMCs). In addition, the functional abilities of early decidual γδ T cells in promoting trophoblast cell proliferation, migration, invasion and tube formation were also significantly more robust than in γδ T cells of PBMCs. These findings highlight the importance of γδ T cells in fetal growth and maternal immunotolerance during pregnancy and show that they differ from γδ T cells in PBMCs. We thus recommend additional investigation in this research area to further elucidate a role for γδ T cells in pregnancy.
Competition in Psychology and Experimental Economics
Authors: Haran Uriel , Bereby-Meyer Yoella 
Published: June 2022

Abstract
Competition is a fundamental phenomenon in human behavior and a key topic of interest for psychologists and economists alike. Both psychology and economics strive to better understand behavior in competitive environments, but they differ in their research objectives, theoretical perspectives, and empirical methods. Economics typically adopts a normative approach, assuming that agents make rational decisions that balance the tradeoff between the costs of competing and the benefits associated with winning. Economists view competition as a class of incentive structures and investigate the effects of comparative reward schemes on behavior and performance. Psychology adopts a more descriptive approach. Psychologists are interested in the cognitive, affective, and motivational processes that affect decision making. They examine the interpersonal effects of competition and compare them with other social situations. In this chapter, the authors review selected literature on competition in experimental economics and psychology, exploring two common research areas. One is rank-order, effort-based tournaments, by which experimental economists study the effects of various incentive structures on effort and performance, whereas social psychologists examine processes of social comparison. The second is common value auctions and the winner’s curse. The authors discuss how research in economics and psychology examine the winner’s curse, explanations for the phenomenon, and recommendations to overcome it. Finally, the authors outline possible directions for mutual enrichment for scholars interested in competition. Psychologists can benefit from the precise definitions present in economic experiments, whereas economists can use the insights on the underlying processes of competitive attitudes and behavior offered by research in psychology.