bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemical characterization of cape gooseberry (Physalis peruviana L.) fruits ecotype Colombia during preharvest development and growth
Authors: Avendaño William A. , Muñoz Hector F. , Leal Lina J. , Deaquiz Yuli A. , Castellanos Diego A. 
Published: September 2022

AbstractCape gooseberry fruits are increasingly recognized due to their excellent organoleptic and functional characteristics as a food. As the cultivation of this fruit expands, it is necessary to determine the quality characteristics and evolution of the new growing zones. This study sought to characterize the growth and development of cape gooseberry fruits, Ecotype Colombia, in the Ventaquemada region (Department of Boyacá in Colombia). For the experiments, 50 plants were taken completely at random from which 20 flowers of the middle third were selected and marked considering that 50% of the flowers were open. The selected cape gooseberry plants were 9 months old from the establishment. Samples were carried out every 5–7 days to evaluate changes in different physiological and physicochemical properties of the fruits such as equatorial diameter, weight, dry matter, respiration intensity (RI), total soluble solids (SST), titratable acidity (TA), and maturity ratio (SST/TA). Logistic and modified enzyme kinetics models were fitted to represent the change in these characteristics as a function of growth time and to establish a suitable maturity index. A rapid increase in the growth and a substantive change in the properties of the fruits were observed between 36 and 45 days after anthesis (DAA) and stabilization between 60 and 65 DAA, which constitutes the stage of physiological maturity. At this stage, fruits with a polar/equatorial diameter of 2.2–2.5 cm, 14.9% TSS, 2.2% TA, and 191.7 cm3 CO2/g/d RI were obtained. Likewise, from the adjusted models, it was possible to identify these changes, especially for the relative growth rate (RGR), color index, and maturity ratio.Practical ApplicationIn this work, we present the characterization of some physicochemical properties of cape gooseberry throughout its development and preharvest growth. This fruit is of wide interest due to its broad nutritional properties and is known as a “superfruit.” The monitoring of the changes in the quality characteristics is important because it allows producers to define an optimum maturity stage for its commercialization. We also fit suitable regression models to relate the evolution in the product as a function of time and provide prediction tools to monitor fruit development. The above can help growers better schedule their production cycles.
Physicochemical, functional, and digestive characteristics of tea seed cake protein obtained by ultrafiltration
Authors: Liang Li , Xiao Yali , Zhang Jixian , Liu Xiaofang , Wen Chaoting , Zhang Huijuan , Wang Jing , Ren Jiaoyan , Liu Guoyan , Xu Xin 
Published: September 2022

AbstractTo make full use of tea seed cake protein (TSCP), this study investigated the physicochemical and functional properties of TSCP, including the TSCP extract and three ultrafiltration fractions TSCP‐1 (Mw > 10 kDa), TSCP‐2 (3.5 kDa < Mw < 10 kDa), and TSCP‐3 (Mw < 3.5 kDa). After ultrafiltration, the content, thermal stability, and surface hydrophobicity of TSCP were increased, and the molecular weight distribution and structure of TSCP showed significant differences. In terms of functionality, each fraction showed its advantages. Specifically, compared with the others, TSCP had better solubility and foaming properties, and TSCP‐1 had significantly higher oil absorption capacity, and TSCP‐2 had better water absorption capacity and emulsifying properties, and TSCP‐3 can flow more easily (p < 0.05). In terms of nutritional value, the content of essential amino acids in all samples was sufficient. The degree of hydrolysis of TSCP was highest (80.98 ± 1.50%), and ultrafiltration decreased digestibility. These results indicated that ultrafiltration effectively improved the structure and functional properties of TSCP, and the obtained fractions can be applied to different scenarios.Practical Application: Tea seed cakes are rich in protein and usually regarded as byproducts during oil processing. Because of its good functional properties, tea seed cake proteins obtained by ultrafiltration have the potential to be used as ingredients for food.
Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients
Authors: Ibarra‐Lecue Inés , Unzueta‐Larrinaga Paula , Barrena‐Barbadillo Rocío , Villate Aitor , Horrillo Igor , Mendivil Begoña , Landabaso Miguel A. , Meana J. Javier , Etxebarria Nestor , Callado Luis F. , Urigüen Leyre 
Published: September 2022

AbstractCannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5‐HT2AR) have been involved in psychosis and, like Akt kinase, are known to be modulated by THC. Likewise, endocannabinoid system dysregulation has been suggested in schizophrenia. The presence of these molecules in blood makes them interesting targets, as they can be evaluated in patients by a minimally invasive technique. The aim of the present study was to evaluate 5‐HT2AR protein expression and the Akt functional status in platelet homogenates of subjects diagnosed with schizophrenia, cannabis use disorder, or both conditions, compared with age‐ and sex‐matched control subjects. Additionally, endocannabinoids and pro‐inflammatory interleukin‐6 (IL‐6) levels were also measured in the plasma of these subjects. Results showed that both platelet 5‐HT2AR and the active phospho (Ser473)Akt protein expression were significantly increased in schizophrenia subjects, whereas patients with a dual diagnosis of schizophrenia and cannabis use disorder did not show significant changes. Similarly, plasma concentrations of anandamide and other lipid mediators such as PEA and DEA, as well as the pro‐inflammatory IL‐6, were significantly increased in schizophrenia, but not in dual subjects. Results demonstrate that schizophrenia subjects show different circulating markers pattern depending on the associated diagnosis of cannabis use disorder, supporting the hypothesis that there could be different underlying mechanisms that may explain clinical differences among these groups. Moreover, they provide the first preliminary evidence of peripherally measurable molecules of interest for bigger prospective studies in these subpopulations.
Social Reproduction of Post‐Soviet Migrant Labour: Braiding the International Political Economy
Authors: Kangas Anni , Krivonos Daria , Khidjobova Safina , Omonillaeva Zarnigor , Jitlina Olga , Tereshkina Anna , Kiromova Mahpora 
Published: September 2022

AbstractIn this article, we analyse the social reproduction of post‐Soviet migrant labour. Our inquiry builds on artwork by Olga Jitlina and Anna Tereshkina and by Mahpora Kiromova dealing with the effects of migration on family relations in Central Asia and the South Caucasus. We have braided the artwork with strands of social reproduction theory to examine the transnational household as a set of relationships that enables post‐Soviet and global capitalism to draw value out of unwaged work and to reproduce the differentiated (i.e. gendered and racialised) labour force. Our focus is on the tropes of family, weddings, love, and violence. The analysis of these tropes draws attention to the intersecting effects of globalised capitalism, local structures of value, the state, and patriarchy in post‐Soviet political economy. Through them we detail the fundamental co‐constitution of production and social reproduction, but also show that practices of social reproduction can be reservoirs of resistance and potential change.
Evoked sensations with transcutaneous electrical stimulation with different frequencies, waveforms, and electrode configurations
Authors: Imatz‐Ojanguren Eukene , Keller Thierry 
Published: September 2022

AbstractBackgroundCurrent Perception Threshold (CPT) is a technique used for diagnostic purposes that applies sinusoidal currents transcutaneously at 5 Hz, 250 Hz, and 2KHz to preferentially excite C, Aδ, and Aβ afferent nerve fibers correspondingly. This fact may be interesting for evoking different electrotactile sensations for a wide variety of applications.MethodsSensations evoked by 5 Hz, 250 Hz, and 2KHz frequencies; sinusoidal, square, and 250 μs‐pulsed waveforms; and conventional and concentric electrode configurations were analyzed in 19 healthy volunteers. Stimuli were applied in the dorsum of the hand in a double‐blind manner and CPTs were defined based on participants' verbal feedback. After each stimulus participants filled in a form with sensation modality, irradiation, intensity, and emotion descriptors.ResultsThe frequency showed a significant effect on the four domains of evoked sensations and the waveform showed a significant effect on the modality domain. For most waveform and electrode configuration combinations, 5 Hz evoked mostly a low‐intensity prickling sensation; 250 Hz mostly evoked an uncomfortable medium‐intensity tingling sensation; and 2KHz mostly evoked a low‐intensity tingling sensation. No thermal or noxious sensations were evoked. A significant interaction effect was only found between the frequency and the waveform factors. The electrode configuration did not show either a significant effect on the evoked sensations or an interaction effect with the frequency or waveform type.ConclusionsTranscutaneous electrical stimulation may evoke different sensations at different frequencies due to the preferential activation of different fiber types. The results of these analysis could be used to enhance human‐machine/computer‐interaction systems based on electrotactile feedback.
The tax advantage of public firms over private firms in the German household solid waste disposal industry
Authors: Krause Marko , Lahmann Alexander 
Published: September 2022

AbstractWe measure the tax advantage of public firms over private firms, which operate at municipality level in the German household solid waste disposal industry. Public firms with sovereign duties pay no taxes, but equivalent private firms have to. In a simple risk‐free setting, we develop a measure of the percentage difference of the charges of both types of firms demanded under their respective tax treatments. We model a cost‐covering public firm and a net present value maximizing private firm. For sensible model parameters from the German waste disposal industry the private firm has to demand an about 16% to 18% higher charge. The by far biggest impact on the measure has the value added tax, with revenues as a much larger tax base than profits. Tax savings, which directly affect pre‐tax profits, only alleviate the disadvantage bit. There is some evidence that at least one type of private firms—that is, private law firms that are also majority privately owned, are productive enough to overcome the tax advantage of public firms and be able to charge a lower price than public firms.
Effects of person–occupation political orientation misfit on occupational identification: An experimental study
Authors: Zacher Hannes , Rudolph Cort W. 
Published: September 2022

AbstractResearchers and practitioners have become increasingly interested in the role of political orientation in the workplace. Importantly, people do not always agree with other members of their profession when it comes to politics. However, the effects of such person–occupation political orientation misfit on people's work‐related attitudes remain unclear. According to the social identity perspective, person–occupation political orientation misfit is likely to lead to the experience of identity threat, which in turn should negatively impact people's occupational identification. To address this idea empirically, the goal of this study was to examine the influence of different political depictions of the field of industrial and organizational (I–O) psychology (i.e. as generally neoliberal, left‐wing, pluralistic, or neutral) on I–O psychologists' occupational identification, depending on their personal political orientation (i.e. more or less liberal vs. conservative). Specifically, we hypothesized that experiencing person–occupation political orientation misfit would reduce occupational identification. Results of an experiment (n = 800 I–O psychology academics and practitioners) provided some support for this hypothesis, suggesting specifically that person–occupation political orientation misfit might alienate people with a more conservative political orientation from their occupation.
Smartphone use and daily cognitive failures: A critical examination using a daily diary approach with objective smartphone measures
Authors: Hartanto Andree , Lee Kristine Y. X. , Chua Yi Jing , Quek Frosch Y. X. , Majeed Nadyanna M. 
Published: September 2022

AbstractWhile smartphones have brought many benefits and conveniences to users, there is continuing debate regarding their potential negative consequences on everyday cognition such as daily cognitive failures. A few cross‐sectional studies have found positive associations between smartphone use and cognitive failures. However, several research gaps remain, such as the use of cross‐sectional designs, confounds related to stable individual differences, the lack of validity in self‐report measures of smartphone use, memory biases in retrospective self‐reports, and the lack of differentiation between smartphone checking and smartphone screen time. To simultaneously address the aforementioned shortcomings, the current study examined the within‐person associations between various objective indicators of smartphone use and daily cognitive failures using a 7‐day daily diary study. Multilevel modelling revealed that smartphone checking, but not total smartphone screen time, predicted a greater occurrence of daily cognitive failures at the within‐person level. Surprisingly, we also found negative within‐person associations between smartphone screen time for social‐ and tools‐related applications and daily cognitive failures, suggesting that some types of smartphone use may temporarily benefit one's cognitive functioning. This finding demonstrates the importance of studying the specific functions of smartphone use and their differential cognitive consequences, as well as highlights the complex relations between smartphone use and cognition.
Penalization approaches in the conditional maximum likelihood and Rasch modelling context
Authors: Gürer Can , Draxler Clemens 
Published: September 2022

AbstractRecent detection methods for Differential Item Functioning (DIF) include approaches like Rasch Trees, DIFlasso, GPCMlasso and Item Focussed Trees, all of which ‐ in contrast to well established methods ‐ can handle metric covariates inducing DIF. A new estimation method shall address their downsides by mainly aiming at combining three central virtues: the use of conditional likelihood for estimation, the incorporation of linear influence of metric covariates on item difficulty and the possibility to detect different DIF types: certain items showing DIF, certain covariates inducing DIF, or certain covariates inducing DIF in certain items. Each of the approaches mentioned lacks in two of these aspects. We introduce a method for DIF detection, which firstly utilizes the conditional likelihood for estimation combined with group Lasso‐penalization for item or variable selection and L1‐penalization for interaction selection, secondly incorporates linear effects instead of approximation through step functions, and thirdly provides the possibility to investigate any of the three DIF types. The method is described theoretically, challenges in implementation are discussed. A dataset is analysed for all DIF types and shows comparable results between methods. Simulation studies per DIF type reveal competitive performance of cmlDIFlasso, particularly when selecting interactions in case of large sample sizes and numbers of parameters. Coupled with low computation times, cmlDIFlasso seems a worthwhile option for applied DIF detection.
HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells
Authors: Maruyama Tsuyoshi , Saito Koji , Higurashi Masato , Ishikawa Fumihiro , Kohno Yohko , Mori Kazunori , Shibanuma Motoko 
Published: September 2022

AbstractRecent comprehensive analyses of mtDNA and orthogonal RNA‐sequencing data revealed that in numerous human cancers, mtDNA copy numbers and mtRNA amounts are significantly reduced, followed by low respiratory gene expression. Under such conditions (called mt‐Low), cells encounter severe cell proliferation defects; therefore, they must acquire countermeasures against this fatal disadvantage during malignant transformation. This study elucidated a countermeasure against the mt‐Low condition‐induced antiproliferative effects in hepatocellular carcinoma (HCC) cells. The mechanism relied on the architectural transcriptional regulator HMGA2, which was preferably expressed in HCC cells of the mt‐Low type in vitro and in vivo. Detailed in vitro analyses suggest that HMGA2 regulates insulin‐like growth factor binding protein 1 (IGFBP1) expression, leading to AKT activation, which then phosphorylates the cyclin‐dependent kinase inhibitor (CKI), P27KIP1, and facilitates its ubiquitin‐mediated degradation. Accordingly, intervention in the HMGA2 function by RNAi resulted in an increase in P27KIP1 levels and an induction of senescence‐like cell proliferation inhibition in mt‐Low‐type HCC cells. Conclusively, the HMGA2/IGFBP1/AKT axis has emerged as a countermeasure against P27KIP1 CKI upregulation under mt‐Low conditions, thereby circumventing cell proliferation inhibition and supporting the tumorigenic state. Notably, similar to in vitro cell lines, HMGA2 was likely to regulate IGFBP1 expression in HCC in vivo, thereby contributing to poor patient prognosis. Considering the significant number of cases under mt‐Low or the threat of CKI upregulation cancer‐wide, the axis is noteworthy as a vulnerability of cancer cells or target for tumor‐agnostic therapy inducing irreversible cell proliferation inhibition via CKI upregulation in a large population with cancer.
A PI3Kγ signal regulates macrophage recruitment to injured tissue for regenerative cell survival
Authors: Zhou Siyu , Liu Zhengcheng , Kawakami Atsushi 
Published: September 2022

AbstractThe interaction between immune cells and injured tissues is crucial for regeneration. Previous studies have shown that macrophages attenuate inflammation caused by injuries to support the survival of primed regenerative cells. Macrophage loss in zebrafish mutants like cloche (clo) causes extensive apoptosis in the regenerative cells of the amputated larval fin fold. However, the mechanism of interaction between macrophage and injured tissue is poorly understood. Here, we show that a phosphoinositide 3‐kinase gamma (PI3Kγ)‐mediated signal is essential for recruiting macrophages to the injured tissue. PI3Kγ inhibition by the PI3Kγ‐specific inhibitor, 5‐quinoxalin‐6‐ylmethylene‐thiazolidine‐2,4‐dione (AS605240 or AS), displayed a similar apoptosis phenotype with that observed in clo mutants. We further show that PI3Kγ function during the early regenerative stage is necessary for macrophage recruitment to the injured site. Additionally, protein kinase B (Akt) overexpression in the AS‐treated larvae suggested that Akt is not the direct downstream mediator of PI3Kγ for macrophage recruitment, while it independently plays a role for the survival of regenerative cells. Together, our study reveals that PI3Kγ plays a role for recruiting macrophages in response to regeneration.
Variations in calling behaviour of wing dimorphic male crickets
Authors: Zeng Yang , Zhang Jiu‐Yun , Zhu Dao‐Hong 
Published: September 2022

Abstract
A trade‐off between flight and reproduction has been well studied in wing dimorphic female insects but less attention has been given to this trade‐off in males.
In this study, the authors analysed the differences in the calling behaviours of long‐winged (LW) and short‐winged (SW) male Velarifictorus aspersus crickets. Furthermore, the authors examined the effects of flight and wing dealation on the calling behaviour of LW males, as well as female preferences regarding the calling songs of males.
The results showed that SW males sang more often than LW males during the first 9 days after emergence, but there were no significant differences in the song characteristics of SW and LW males. A flight of 5 min increased the singing time by LW males without changing the song characteristics, but a flight of 30 min or wing dealation increased both the singing time and chirp number per song. In binomial choice trials, female crickets did not prefer SW calling song to unflown LW calling song. But when LW males had either flown 30 min or been dealated, females preferred LW to SW calling song.
Therefore, LW males may attract fewer females than SW males when they are preparing for dispersal, but this reproductive disadvantage may be absent during dispersal and the settling stage.
New links for meprin β within the protease web
Authors: Canbay Vahap , auf dem Keller Ulrich 
Published: September 2022

Proteases are organised in interconnected networks, together forming the protease web whose disturbance can have detrimental consequences for tissue homeostasis and response to environmental insults. Membrane‐anchored sheddases are proteases that themselves can be released into the pericellular space by ectodomain shedding. Werny et al. have uncovered unexpected promiscuity in ectodomain shedding of meprin β, a metalloprotease with critical functions in inflammation and fibrosis. These findings suggest new links within complex proteolytic networks like the epidermal protease network with potential implications for skin homeostasis, inflammation and response to injury.Comment on: https://doi.org/10.1111/febs.16586
Wet and dry extremes reduce arthropod biomass independently of leaf phenology in the wet tropics
Authors: Newell Felicity L. , Ausprey Ian J. , Robinson Scott K. 
Published: September 2022

AbstractWarming temperatures are increasing rainfall extremes, yet arthropod responses to climatic fluctuations remain poorly understood. Here, we used spatiotemporal variation in tropical montane climate as a natural experiment to compare the importance of biotic versus abiotic drivers in regulating arthropod biomass. We combined intensive field data on arthropods, leaf phenology and in situ weather across a 1700–3100 m elevation and rainfall gradient, along with desiccation‐resistance experiments and multi‐decadal modelling. We found limited support for biotic drivers with weak increases in some herbivorous taxa on shrubs with new leaves, but no landscape‐scale effects of leaf phenology, which tracked light and cloud cover. Instead, rainfall explained extensive interannual variability with maximum biomass at intermediate rainfall (130 mm month−1) as both 3 months of high and low rainfall reduced arthropods by half. Based on 50 years of regional rainfall, our dynamic arthropod model predicted shifts in the timing of biomass maxima within cloud forests before plant communities transition to seasonally deciduous dry forests (mean annual rainfall 1000–2500 mm vs. <800 mm). Rainfall magnitude was the primary driver, but during high solar insolation, the ‘drying power of air’ (VPDmax) reduced biomass within days contributing to drought related to the El Niño‐Southern Oscillation (ENSO). Highlighting risks from drought, experiments demonstrated community‐wide susceptibility to desiccation except for some caterpillars in which melanin‐based coloration appeared to reduce the effects of evaporative drying. Overall, we provide multiple lines of evidence that several months of heavy rain or drought reduce arthropod biomass independently of deep‐rooted plants with the potential to destabilize insectivore food webs.