bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of information on mitigating SUS's judicialization in digital media
Authors: Siqueira Fernanda Rodrigues de , Müller Carlos André da Silva , Siena Osmar 
Published: April 2022

PurposeThis research aimed to analyze how information on public policies to mitigate the judicialization of the SUS (Brazilian Unified Health System) have been disseminated via digital media to citizens and stakeholders.Design/methodology/approachUnder a qualitative and inductive paradigm, the research was based on the search for news on the Google pages. Data were grouped into higher categories to formalize theoretical generalizations.FindingsData analysis showed that there are news classified into 11 codes, forming three news groups broadcast as an effort by the programs to legitimize themselves with society: Perceived Quality, Publicity Produced and Results Achieved.Research limitations/implicationsThe relationship between the effectiveness of public policies and their dissemination in digital media has implications for the result/legitimacy relationship, not excluding that public marketing can make a program legitimate without having results that confirm its effectiveness.Social implicationsThe work provides a means of understanding the dissemination of public policies, in particular, verifying whether these are being provided in order to establish responsible and transparent communication with the citizen or to legitimize public policies without effective results.Originality/valueThe proposed conceptual model is based on four quadrants and represents the relationship between the results achieved by public policies and legitimacy, considering a phenomenon resulting from public marketing. The association between the intensity of these constructs constitutes four themes: fake public marketing, inefficient public policy, deficient public marketing and full public policy.
Intelligent pore type characterization: Improved theory for rock physics modelling
Authors: Sharifi Javad 
Published: April 2022

ABSTRACTThanks to the recent developments in both hardware and software capabilities of computers, intelligent rock physics modelling has emerged as an alternative to the conventional approach to the rock physics. Respecting the crucial contribution of the pore geometry into the rock physics modelling, I propose an accurate yet cost‐ and time‐efficient intelligent framework to measure pore space based on digital rock physics. In this method, total pore space was calculated after estimating the pore geometry through pattern recognition on thin section images captured through polarized‐light microscopy. Next, applying three different multi‐class classifiers (radial basis function, support vector machine and k‐nearest neighbours) for estimating pore type and aspect ratio, the best results were obtained using the fuzzy Sugeno integral, and the pore types were classified according to the most widely used pore type classification scheme. Next, an artificial neural network was applied to interpolate discrete data points (thin sections) into continuous profiles of pore type and aspect ratio. Subsequently, as a case study, the proposed approaches were applied to a real‐world carbonate reservoir for modelling the P‐ and S‐wave velocities through a rock physics model. Verifying the modelling results against ultrasonic and measured well‐logging data, the methodology showed promising performance at acceptable levels of uncertainty. The most significant advantage of the intelligent pore type quantification over the conventional methods was found to be its ability to estimate elastic properties with good accuracy. The key findings of this research include automatic detection of the pore types and aspect ratio, provision of a database of pore geometry, attenuation of uncertainty in pore type characterization and improvement of rock physics modelling in the absence of reliable S‐wave velocity data.
Venous blood for the analysis of acid–base status in a model of septic shock
Authors: Maiden Matthew J , Fraser Jonathan D , Finnis Mark E 
Published: April 2022

AbstractObjectiveTo determine the relationship between arterial and venous acid–base status in a model of septic shock.MethodsPaired samples (n = 435) of arterial and femoral venous blood from 57 sheep (47 septic, 10 non‐septic) managed with protocol‐guided ventilation, sedation, parenteral fluids and inotropic support.ResultsThe arterial‐venous difference in acid–base parameters was similar with and without sepsis. There was a consistent arterio‐venous relationship for metabolic (pH, lactate, bicarbonate, base excess), but not respiratory parameters (partial pressures of oxygen, carbon dioxide, and haemoglobin‐oxygen saturation), independent of sepsis.ConclusionsVenous blood provides a reliable measure of metabolic but not respiratory disturbance.
Traditional grazing management creates heterogeneous swards and fosters grasshopper densities
Authors: Schwarz Cinja , Fartmann Thomas 
Published: April 2022

AbstractCommon pastures were once the dominant type of land use in many European regions. However, during the past 150 years, they have declined dramatically. Recent studies have shown that they are hotspots for rare plant, butterfly, and bird species in the study area, the Bavarian pre‐Alps (southern Germany). However, studies on the value of these pastures for Orthoptera (hereinafter termed “grasshoppers”) have been scarce. Here, we studied the effects of traditional summer grazing in common pastures on grasshopper assemblages. Our study revealed that grasshopper species richness did not differ between common pastures (n = 57) and controls (n = 57). By contrast, density of all and of threatened species varied between common pastures and controls in all plots and within the two vegetation types with the highest grasshopper abundance, grasslands on mineral soil and fens. Two threatened species, Pseudochorthippus montanus and Stethophyma grossum, were identified as indicators for common pastures; controls had no indicative species. Traditional low‐intensity grazing in common pastures has resulted in open and heterogeneous swards with some bare ground, a low cover of litter and an intermediate vegetation height favouring high densities of grasshopper species in general and threatened species in particular. This is especially true for the two most productive vegetation types, grasslands on mineral soil and fens. To promote biodiversity in general and grasshopper densities in particular, we recommend maintaining traditional cattle grazing (stocking capacities: 0.5–2.0 livestock units/ha) in common pastures. Where possible, this grazing regime should also be introduced in the surrounding landscape.
Patient characteristics, management and outcomes in a Nordic subset of the “large observational study to understand the global impact of severe acute respiratory failure” (LUNG SAFE) study
Authors: Laake Jon Henrik , Småstuen Milada Cvancarova , Møller Morten Hylander , Larsson Anders , Aslam Tayyba Naz , Hofsø Kristin , Pham Tài , Fan Eddy , Bellani Giacomo , Laffey John G. ,   LUNG SAFE Investigators
Published: April 2022

AbstractBackgroundThe “Large observational study to understand the global impact of severe acute respiratory failure” (LUNG SAFE) study described the worldwide epidemiology and management of patients with acute hypoxaemic respiratory failure (AHRF). Here, we present the Nordic subset of data from the LUNG SAFE cohort.MethodsWe extracted LUNG SAFE data for adults fulfilling criteria for AHRF in intensive care units (ICU) in Denmark, Norway and Sweden, including demographics, co‐morbidities, clinical assessment and management characteristics, 90‐day survival and length‐of‐stay (LOS). We analysed ICU LOS with linear regression, and associations between risk factors and mortality were quantified using Cox regression.ResultsWe included 192 patients, with a median age of 64 years (IQR 55, 72), and a male‐to‐female ratio of 2:1. The majority had one or more co‐morbidities, and clinicians identified pneumonia as the primary cause of respiratory failure in 56% and acute respiratory distress syndrome (ARDS) in 21%.Median ICU LOS and duration of invasive mechanical ventilation (IMV) were 5 and 3 days. Tidal volumes (TV) were frequently larger than that supported by evidence and IMV allowing for spontaneous ventilation was common. Younger age, co‐morbidity, surgical admission and ARDS were associated with ICU LOS. Sixty‐one patients (32%) were dead at 90 days. Age and a non‐surgical cause of admission were associated with death.ConclusionsIn this subset of LUNG SAFE, ARDS was often not recognised in patients with AHRF and management frequently deviated from evidence‐based practices. ICU LOS was generally short, and mortality was attributable to known risk factors.
Cutworms (Lepidoptera: Noctuidae) in central Brazil Savanna: temporal distribution and association of species abundance with climatic and meteorological factors
Authors: Specht Alexandre , Dias Fernando M S , Carneiro Eduardo , Casagrande Mirna M , Mielke Olaf H H , Xavier Rodrigo A , Roque‐Specht Vânia F , Malaquias Juaci V , Silva Fernando A M , Claudino Vander C M 
Published: April 2022

AbstractPopulation dynamics studies make it possible to predict the response of species to seasonal and inter‐annual climatic phenomena in hypothetical scenarios of climatic abnormality. However, long‐term studies on the temporal distribution and abundances of species are still scarce in the literature, including for species of agricultural importance. The present study aimed to bridge this gap through monthly collection events of species of cutworms (species of Agrotis and Feltia) across eight crop seasons (from July 2012 to June 2020) in the Brazilian Savanna (Cerrado). This biome is characterised by an irregular distribution of rainfall during a normal year, including two well‐defined periods of dry and rainy seasons. Only five species of cutworms were recorded: Agrotis ipsilon, Agrotis canities, Feltia repleta, Feltia submontana and Feltia subterranea, all widely distributed across South America. Except for F. submontana, occurring only in the autumn, other species occurred nearly year‐round, with distinct peaks of abundance in the dry season (April to October), supporting the hypothesis that species of Agrotina are well adapted to dry environments. The association of cutworms with dry environments was recovered for multivoltine, abundant species, such as A. ipsilon and F. subterranea, as for univoltine species, such as F. submontana. Across eight crop seasons, the abundance of all species decreased, coinciding with a high intensity El Niño effect. However, the effect itself was not found to be significant to predict the temporal distribution and abundances of cutworms and the causes of population decrease from 2014 to 2015 crop season remain to be explained. After the temporal autocorrelation effects were removed, it was revealed that the abundance of cutworms tends to be larger in crop seasons with less precipitation. Thus, this variable can be used to predict outbreaks of cutworms in the Cerrado. Some species of cutworms deserve special concern due to their frequency, seasonality and higher abundances in the Cerrado during the dry season. Their adaptability to adverse conditions may increase their spatio‐temporal distribution in Brazil and the frequency of outbreaks in a scenario of climate change, with the continuing reduction of rainfall in central and southeastern Brazil.
Seasonality of Pemba flying fox (Pteropus voeltzkowi) in selected habitats of Pemba Island, and its roles in seed dispersal and germination
Authors: Mwinyi Ali M. , Nnko Happiness J. 
Published: April 2022

AbstractUnderstanding population variation in space and time can be used to enhance protection of keystone species. This study assessed Pteropus voeltzkowi seasonal use of four roosting sites characterised by three habitat types: Community conserved land (CCLH), Residential (RH) and Forest reserve (FRH). To provide information on their keystone role, the study recorded instances of seed dispersal and measured seed germination rate of two and four plant species respectively. A total of 88 roosting locations (18, 20 and 50 from CCLH, RH and FRH respectively) were studied. P. voeltzkowi abundance was estimated using patch counts conducted for four days in dry season (February) and four days in wet season (April). Transect and seed germination experiment were used to estimate seeds dispersal distances and germination rates respectively. The number of P. voeltzkowi was lower in the wet season and highest in RH. A positive relationship was found between P. voeltzkowi abundance and roosting tree canopy diameter. Fruits were dominant food item recorded, eighteen tree species were utilised as day roosts and fourteen were food source for P. voeltzkowi. Compared to unhandled seeds, handled seeds showed high germination rate. Maximum dispersal distances recorded were 560 and 200m for fig and mango seeds respectively.
Protective effect of remote ischemic postconditioning in rat testes after testicular torsion/detorsion
Authors: Hu Zhaoyang , Liu Quanhua , Yan Zhibing , Wang Qifeng , Liu Jin 
Published: April 2022

AbstractBackgroundTesticular torsion/detorsion can lead to severe testicular damage. The organ‐protective effect of remote ischemic postconditioning (RLIPost) against ischemia/reperfusion injury has been characterized; however, it remains unknown whether RLIPost has a testicular protective effect.ObjectivesHere, we tested the hypothesis that RLIPost can protect the testes in a rat model of testicular torsion/detorsion in vivo.Materials and methodsMale Sprague–Dawley rats were assigned to sham‐operated, control, or remote liver and limb ischemic postconditioning‐treated groups. Testicular torsion/detorsion was performed by 3 h of testicular torsion (720° clockwise unilateral spermatic cord torsion), followed by 3 h of detorsion. For liver and limb ischemic postconditioning, four cycles of 5 min of liver or limb ischemia with 5‐min intermittent reperfusion stimuli were conducted at the onset of testicular reperfusion.ResultsLiver and limb ischemic postconditioning significantly ameliorated ipsilateral and contralateral testicular swelling responses, preserved morphological integrity and spermatogenesis and inhibited testicular apoptosis. In addition, RLIPost enhanced the phosphorylation of AKT/ERK1/2/GSK‐3β/STAT‐3 in the ipsilateral testis while suppressing JNK activation in the ipsilateral and contralateral testes.Discussion and conclusionTo the best of our knowledge, this study is the first to demonstrate the involvement of RLIPost in an animal model of testicular torsion/detorsion. We showed that RLIPost protects both ipsilateral and contralateral testes against testicular torsion/detorsion in vivo, via at least in part, the RISK and SAFE‐mediated signaling pathways.
Routine conversations about violence conducted in Swedish child health services—A mixed methods study of nurses' experiences
Authors: Nimborg Jennie , Lindskog Ulrika , Nordgren Lena , Annerbäck Eva‐Maria 
Published: April 2022

AbstractAimTo evaluate an intervention where nurses in child health care services routinely talk to and inform parents about violence.MethodsThe intervention included providing information during home visits and individual conversations with mothers and fathers/partners in connection with screening for parental depression. A convergent mixed‐methods design was used with a documentation form for each child (n = 475) and results from focus group interviews with nurses. Quantitative data were analysed using descriptive statistics and qualitative with manifest content analysis.ResultsAlmost all families participated in the intervention; individual conversations were conducted with nearly all the mothers, and to a somewhat lesser extent with the fathers/partners. Initially, the nurses felt slightly uncomfortable about these conversations, but described experiencing development and professionalisation in their role of talking about violence. Parents' reactions were generally positive and they expressed appreciation for this topic being raised.ConclusionThe results show that the intervention has been carried out successfully. The newborn period is a phase in which mothers and fathers are interested and receptive to knowledge and support in sensitive matters. Prerequisites for implementation were the preparation phase for the nurses, the use of routine questioning and a questionnaire as a basis for the conversations.
Becoming a pirate: Independence as an alternative to exit in the gig economy
Authors: Maffie Michael David 
Published: April 2022

AbstractHow and why do platform workers ‘quit’? Drawing on original qualitative data from 84 ride‐hail drivers, the author finds that platform companies use information asymmetries to downplay the true cost of working a ‘gig’. Once workers realize these costs, some exit, yet others cannot because they have come to rely on their ride‐hail income to meet their short‐term needs, a phenomenon the author refers to as ‘acquired dependence’. In response, the author finds these workers begin their own ‘pirate’ (illegal) taxi operations to decrease their dependence on platform companies. These findings are then used to develop an original survey instrument that tests if drivers’ ‘acquired dependence’ is associated with ‘pirate’ taxi operations. Using survey data from 330 ride‐hail drivers, the author finds evidence that drivers with greater acquired dependence are more likely to develop off‐app ‘pirate’ taxi operations. In doing so, this article develops both a new category of conflict and response for marketized employment relationships.
Matrix metalloproteinase‐21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC
Authors: Zhou Jiangfan , Liu Li , Hu Xudong , Feng Rong , Zhao Niannian , Zhang Li , Hu Wenhao , Zhang Jian , Huang Shiyong , Liu Lin , Li Wei , Shan Yunfeng , Jin Jing 
Published: April 2022

AbstractMMP‐21 is a newly identified member of the matrix metalloproteinase family and has been reported to regulate both embryonic development and tumor progression. However, the roles of MMP‐21 in hemofiltrate C–C chemokine (HCC) remain largely unclear. In this study, we used western blot, qPCR and immunohistochemistry (IHC) to determine the upregulation of MMP‐21 in HCC tissues, and showed that the increase in MMP‐21 was associated with vascular invasion and poor prognosis. Although changing levels of MMP‐21 in HCC cell lines had no significant effect on cell migration or invasion abilities in in vitro transwell tests, both IHC analysis and in vivo mouse models proved that upregulated MMP‐21 promoted metastasis. Functional enrichments of MMP‐21 using The Cancer Genome Atlas (TCGA) data suggested that MMP‐21 might regulate metastasis via macrophages. Further experiments proved that MMP‐21 enhanced macrophage recruitment by increasing CCL‐14 levels and promoted M2‐type polarization of macrophage by elevating the expression of CSF‐1 and FGF‐1. Taken together, this study revealed that MMP‐21 controlled the tumor microenvironment remodeling and functional regulation of macrophages to regulate HCC metastasis.
Tumor‐targeted fluorescence labeling systems for cancer diagnosis and treatment
Authors: Tazawa Hiroshi , Shigeyasu Kunitoshi , Noma Kazuhiro , Kagawa Shunsuke , Sakurai Fuminori , Mizuguchi Hiroyuki , Kobayashi Hisataka , Imamura Takeshi , Fujiwara Toshiyoshi 
Published: April 2022

AbstractConventional imaging techniques are available for clinical identification of tumor sites. However, detecting metastatic tumor cells that are spreading from primary tumor sites using conventional imaging techniques remains difficult. In contrast, fluorescence‐based labeling systems are useful tools for detecting tumor cells at the single‐cell level in cancer research. The ability to detect fluorescent‐labeled tumor cells enables investigations of the biodistribution of tumor cells for the diagnosis and treatment of cancer. For example, the presence of fluorescent tumor cells in the peripheral blood of cancer patients is a predictive biomarker for early diagnosis of distant metastasis. The elimination of fluorescent tumor cells without damaging normal tissues is ideal for minimally invasive treatment of cancer. To capture fluorescent tumor cells within normal tissues, however, tumor‐specific activated target molecules are needed. This review focuses on recent advances in tumor‐targeted fluorescence labeling systems, in which indirect reporter labeling using tumor‐specific promoters is applied to fluorescence labeling of tumor cells for the diagnosis and treatment of cancer. Telomerase promoter‐dependent fluorescence labeling using replication‐competent viral vectors produces fluorescent proteins that can be used to detect and eliminate telomerase‐positive tumor cells. Tissue‐specific promoter‐dependent fluorescence labeling enables identification of specific tumor cells. Vimentin promoter‐dependent fluorescence labeling is a useful tool for identifying tumor cells that undergo epithelial–mesenchymal transition (EMT). The evaluation of tumor cells undergoing EMT is important for accurately assessing metastatic potential. Thus, tumor‐targeted fluorescence labeling systems represent novel platforms that enable the capture of tumor cells for the diagnosis and treatment of cancer.
Clinicopathological prognostic parameters in patients with tubo‐ovarian carcinoma effusions
Authors: Davidson Ben , Elstrand Mari Bunkholt 
Published: April 2022

AbstractObjectiveTo analyse the predictive and prognostic role of clinicopathological parameters in patients with tubo‐ovarian carcinoma and malignant effusion.MethodsA retrospective series of 700 malignant peritoneal (n = 610) and pleural (n = 90) effusions from 558 patients was revised for histotype based on the 2014 World Health Organization criteria. The role of clinicopathological parameters in determining outcome was assessed.ResultsThe majority of specimens (597 effusions from 473 patients) were high‐grade serous carcinomas (HGSC), followed by low‐grade serous carcinoma (LGSC; 48 effusions, 37 patients), clear cell carcinoma (CCC; 23 effusions, 19 patients) and carcinosarcoma (CS; 16 effusions, 16 patients). Patients with CCC and CS had the shortest, those with HGSC intermediate, and those with LGSC longest overall and progression‐free survival (both P < 0.001). For patients with HGSC, older age (P = 0.002), more advanced FIGO stage (IV vs III; P < 0.001), delayed/no surgery (P < 0.001), larger residual disease volume (RD; P < 0.001), non‐complete response to chemotherapy at diagnosis (P < 0.001), and primary platinum resistance (P < 0.001) were associated with shorter overall survival. In Cox multivariate analysis, FIGO stage (P = 0.002) and primary platinum resistance (P < 0.001) were independent prognosticators. Significant association was additionally found for parameters analysed for progression‐free survival in HGSC (previous chemotherapy: P = 0.029; age: P = 0.046; FIGO stage, upfront therapy, RD: P < 0.001), of which previous chemotherapy, upfront therapy, and RD were independent prognosticators (all P < 0.001).ConclusionsThe vast majority of malignant effusions in patients with tubo‐ovarian carcinoma are derived from serous carcinoma or related tumours, such as CS. Histology is a powerful prognostic factor in this patient group, as are established clinical parameters.
Complex care in a family‐oriented setting is crucial for parental support
Authors: Beeri Maurit 
Published: April 2022

This commentary is on the original article by Bogetz et al. on pages 840–846 of this issue.Video Podcast: https://urldefense.com/v3/__https:/www.youtube.com/watch?v=A7m9K4A50XE&ab_channel=DMCNvideos__;!!N11eV2iwtfs!oE9A3fucKFe8dT1-AL8EOhZKl73TWlze76RoIAd_P5yfrygZnCVB-fvwS9TVxKNCZBJLzoXbe8lkG4YX7e9QJag$