bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence of Depression and Anxiety in Women with Ovarian Cancer: An Updated Systematic Review and Meta-Analysis of Cross-Sectional Studies
Authors: Ghamari Darya , Dehghanbanadaki Hojat , Amini Elnaz Ezzati , Nouri Elham , Baiezeedi Sheno , Azami Mobin , Khateri Sorour , Moradi Yousef 
Published: February 2022

Abstract
Background: This study aimed to determine the pooled prevalence of anxiety and depression in women with ovarian cancer.Methods: Databases (PubMed [Medline], Scopus, Web of Science, Embase, and PsycInfo) were searched to retrieve all cross-sectional studies between July 2013 and October 2021. All analyses were performed using STATA 16, and the random-effects model was applied to calculate the pooled prevalence with a 95% confidence interval (95%CI).Results: Out of the 18 selected cross-sectional studies, 17 reported depression prevalence, and 16 reported anxiety prevalence in women with ovarian cancer. The pooled prevalence of depression and anxiety was 27% (95%CI: 14%-41%; I2=69.44%) and 33% (95%CI: 21%-44%; I2=78.55%), respectively.Conclusion: Based on this result, the prevalence of depression and anxiety in women with ovarian cancer was higher than in the healthy female population. Thus, health policymakers should provide the facilities for doing more studies such as cohorts to measure the effect of various treatments or interventions to reduce the mental disorders in women with ovarian cancer.
Evaluation of Mercury, Arsenic, Lead and Cadmium in River Water Intended for Human Consumption as a Consequence of Mining Activities.
Authors: ZEA ANGELICA , ANGAMARCA DIEGO , VALAREZO LEIVER 
Published: February 2022

Abstract
The vast majority of mineral deposits that exist in Ecuador are located in the Andean zone, and in this sense it is important to carry out permanent monitoring of heavy metals present in the soil, and mainly in the water, especially in places where One of its economic activities is mining, with this background this work is based on monitoring potentially toxic elements: Mercury, Arsenic, Lead and Cadmium, these being the main ones that cause damage to the health of the population due to their toxic effects , the monitoring of these toxic elements is carried out in the upper basin of the Santa Rosa River, this place is selected due to the mining activity that exists in the Santa Rosa canton, province of El Oro-Ecuador, 10 sampling points are selected to the along 81 kilometers of the river basin and samples are included in the water plant, the same one that is destined for human consumption, the analysis of the samples was carried out by E Atomic Emission Spectroscopy with Inductive Coupling Plasma (ICP-AES), the results obtained show contamination of the water resource, according to the United States Environmental Protection Agency (EPA), and INEN 1108, World Health Organization ( WHO), and the applied surveys show the use of this water in different activities, both domestic and agricultural, therefore the objective of this work is to raise awareness in the community in general about the importance of taking care of the water resource and taking all preventive measures for public health.
Changes In Corneal Surface Aberrations And Nerve Density After Cataract Surgery Of Patients With Dry Eye Disease
Authors: Jing Dalan , Jiang Xiaodan , Chou Yilin , Wei Shanshan , Hao Ran , Su Jie , Li Xuemin 
Published: February 2022

Abstract
Purpose: To evaluate the change patterns in corneal aberrations and nerve density after cataract surgery in dry eye disease (DED).Methods: One hundred and six eyes of 69 patients with dry eye were included in this study. The preoperative, 1-month and 3-month postoperative dry eye-related indices were obtained by the Oculus keratograph and the ocular surface disease index (OSDI) questionnaire. The corneal aberrations and corneal surface regularity indices were measured using a Pentacam HR system. In vivo confocal microscopy (ICVM) was performed to observe sub-basal corneal nerves of vortex and superior periphery, and corneal endothelial number. An artificial intelligence (AI) technique run by the deep learning model generated the sub-basal nerve fibre parameters.Results: One hundred and six eyes of 69 patients with DED (mean age, 69.32±8.91 years) were recruited. Corneal aberrations on the anterior and total corneal surfaces increased significantly at 1 month after surgery compared with the baseline values but gradually returned to the baseline by 3 months after surgery. Significant changes in posterior corneal HOAs occurred at 1-month and 3-month. Corneal endothelial cells decreased continuously until 3 months after operation. There were significantly lessen in corneal vortical nerve maximum length and average density after operation, these damages were present after 3 months. But for corneal peripheral nerve, these damages lasted only 1 month after operation. The corneal vortical nerve maximum length and average density were negatively correlated with anterior corneal surface aberrations before and one month after surgery. Conclusions: After cataract surgery, changes in corneal aberrations occurred mainly both on the anterior and posterior surface. However, the change of posterior lasts longer. The corneal vortical nerve maximum length and average density are reduced after cataract surgery in patients with DED. Although the anterior corneal aberration will recover one month after cataract surgery, the dry eye state continues to worsen. IVCM is a useful tool to evaluate corneal sub-basal nerve changes in dry eye patients before and after cataract operation.
Efficiency of lactoferrin to eradicate multidrug resistant Staphylococcus aureus isolated from some dairy products
Authors: Habty Sayed H. Al , Ali Dina N. 
Published: February 2022

Abstract
Back ground: This study aimed to investigate Staphylococcus aureus (S. aureus) in some dairy products, Genotypically and phenotypically antibiotic resistance pattern as well as to evaluate the effectiveness of lactoferrin (LF) as a bio preservative for yoghurt. Methods: A total of 150 samples from yoghurt, ice cream and Damietta cheese (50 for each) in Assiut city, Egypt. Antimicrobial susceptibility against antibiotics commonly used in human and animals was tested using the disc diffusion method, S. aureus isolates, PCR was applied on multidrug resistant (MDR) S. aureus isolates for detection of blaz, mecA and VanA genesResults: The highest prevalence S. aureus was detected in yoghurt (38%) followed by Damietta cheese (30%) and ice cream (14%). Antimicrobial susceptibility against antibiotics S. aureus isolates showed high resistance to tetracycline, penicillin, oxacillin, ampicillin, streptomycin, amoxicillin/clavulanate and neomycin, in different percentages. blaz, mecA and VanA genes were detected at 60% for blaz gene, 40% for mecA gene and 20% for vanA gene. Lactoferrin has a satisfactory antibacterial activity MIC at 20mg/ml and MLC at 40mg/ml. The results revealed that 40mg/ml LF in yoghurt could inhibit MDR S. aureus at 2nd day while, 20mg/ml at the fourth day.Conclusion: The study concluded that LF can be used as a bio preservative in yoghurt due to its highest antimicrobial activity and acceptable sensorial properties.
Distance for communication between metal and acid sites
Authors: Li Yubing , Wang Mengheng , Liu Suhan , Wu Fangwei , Zhang Qinghong , Zhang Shuhong , Cheng Kang , Wang Ye 
Published: February 2022

Abstract
Unraveling the proximity influence between different sites in tandem catalysis is particularly challenging. Herein, we evaluate the distance effect on the communication between metal and acid sites in a methanol-mediated syngas conversion system. A series of catalysts composed of ZnZrOx and zeolites with different proximity levels from millimeter- to nanoscale-scale were evaluated in the syngas to olefins (STO), gasoline (STG), and aromatics (STA) reactions. The distance requirements are dependent on the diffusivity of reaction intermediates and the formation mechanism of products. The STO and STG reactions follow a simple tandem mechanism, which is not sensitive to the distance as long as the gaseous methanol could fast diffuse to acid sites. Whereas a synergistic tandem mechanism for syngas to aromatics is evidenced, i.e., the dehydro-aromatization step must be promoted by the intimate contact of metal and acid sites to eliminate the surface hydrogen species formed on zeolites.
Prognostic Evaluation Based on Dual Time 18F-FDG PET/CT Radiomics Features in Patients with Locally Advanced Pancreatic Cancer Treated by Stereotactic Body Radiation Therapy
Authors: Wang Fei , Ren Shengnan , Liu Zhaobang , Yang Xiaodong , Wu Zhongyi , Wang Tao , Cheng Chao , Zuo Changjing , Yan Zhuangzhi 
Published: February 2022

Abstract
Background
The prognosis of pancreatic cancer is very poor. We aim to explore the prognostic value of radiomics features from dual time 18F-FDG PET/CT images for locally advanced pancreatic cancer (LAPC) patients treated with stereotactic body radiation therapy (SBRT).
Materials and Methods
This retrospective study included 59 LAPC patients who received early and delayed 18F-FDG PET/CT scans before SBRT treatment. Patients were divided into a training cohort: n = 40, and a validation cohort: n = 19. A total of 1188 quantitative imaging features were extracted from dual time 18F-FDG PET/CT images. To avoid over-fitting, the univariate analysis and elastic net were used to obtain a sparse set of image features, that were applied to develop a radiomics score (Rad-score). Then the Rad-score was used to constructed prognosis models to predict the overall survival (OS) of patients, and stratify the patients. The univariate analysis and multivariate analysis were used to assess the correlation of OS. The Harrell consistency index (C-index) was used to evaluate the model. And the cross-validation was used to ensure the accuracy and robustness of the results.
Results
The Rad-score from dual time images contains 6 features, including intensity histogram, morphological, and texture features. In the validation cohort, the univariate analysis showed that the Rad-score was the independent prognostic factor (p = 0.0001, hazard ratio [HR]: 2.35), which was better than traditional imaging predictive indicators and clinical indicators, such as tumor volume, maximum standardized uptake value, Total glycolysis, and TNM staging. Among all the prognostic factors included in the multivariate analysis, the Rad-score was the only prognostic factor (p < 0.01, HR: 2.71) that was significantly associated with the OS of patients. In addition, according to cross-validation, the C-index of the prognostic model based on the Rad-score of dual-time PET/CT images is better than the model based on early and delay PET/CT images(0.745 vs 0.713 vs 0.593).
Conclusion
Quantitative analysis confirmed that the Rad-score from dual time 18F-FDG PET/CT images have a better prognostic value than the Rad-score from single-time images. It has potential significance for identifying the individualized risk of LAPC patients treated with SBRT.
The decision-making process regarding ovarian tissue cryopreservation in girls with Turner syndrome by patients, parents, and healthcare providers: a mixed-methods study
Authors: Coelen Sanne van der , Velden Janielle van der , Nadesapillai Sapthami , Peek Ron , Braat Didi , Schleedoorn Myra , Fleischer Kathrin , Oerlemans Anke 
Published: February 2022

Abstract
BACKGROUND Girls with Turner syndrome (TS) are missing one of the sex chromosomes, leading to premature ovarian failure. Therefore, girls with TS have poor chances of genetic offspring. Ovarian tissue cryopreservation (OTC) is a fertility preservation technique that has proven to be effective in other patient groups, but the effectiveness in girls with TS is still unclear. Girls with TS are thoroughly counselled before they make a decision about OTC, however, there is a lack of guidelines for counselling. The aim of this study was to gain insight into the experiences of patients, parents, and healthcare providers with the decision-making process regarding OTC in girls with TS. METHODS A mixed-methods study consisting of a survey and four focus group interviews aimed at evaluating the decision-making process of girls with TS considering OTC. Within a year after counselling, a survey was sent to 132 girls with TS and their parents. The survey included questions regarding their experiences with the decision-making process. The focus groups included (1) gynaecologists with subspecialty reproductive medicine, (2) paediatric endocrinologists, (3) parents of girls aged 2 to 12, and, (4) parents of girls aged 13 to 18. Transcripts were analysed using a thematic analysis approach. RESULTS The response rate of the survey was 45%. Of the survey respondents, 90% appreciated counselling regarding their future parenting options and considered it an addition to existing healthcare. The focus groups with parents revealed that most of them had not previously discussed options for future parenthood with a healthcare provider. Girls with TS and their parents indicated that the option of OTC raised hope for future genetic offspring, and instantly made them feel that their only option was to seize this opportunity. Gynaecologists and paediatricians found it challenging to truly make families grasp a realistic perspective of OTC in girls with TS. CONCLUSION Offering young girls with TS the possibility of fertility preservation in an experimental setting raised high hopes and led to challenges for healthcare providers in providing realistic expectations. The appropriate moment for counselling should be tailored to the individual and discussed with the patient, parents and paediatrician. TRIAL REGISTRATION N/A
Rapamycin ameliorates brain damage and maintains mitochondrial dynamic balance in diabetic rats subjected to middle cerebral artery occlusion
Authors: Hei Changchun , Zhou Yujia , Zhang Chenyang , Gao Furong , Cao Meiling , Yuan Shilin , Qin Yixin , Li P. Andy , Yang Xiao 
Published: February 2022

Abstract
Objective To investigate the effect of rapamycin on mitochondrial dynamic balance in diabetic rats subjected to cerebral ischemia-reperfusion injury. Methods Sprague Dawley male rats were treated with high fat diet combined with streptozotocin injection to construct diabetic model in rats. Transient middle cerebral artery occlusion (MCAO) of 2 hours was induced and the brains were harvested after 1 and 3 days of reperfusion. Rapamycin was injected intraperitoneally for 3 days prior to and immediately after operation, once a day. The neurological function was assessed, infarct volumes were measured and histological outcome were examined. The total protein of hippocampus was extracted and Western blotting were performed to detect the levels of mTOR, mitochondrial dynamin related proteins (DRP1, p-DRP1, OPA1), SIRT3, and Nix/BNIP3L.Results Diabetes worsened the neurological function performance, enlarged infarct size and increased ischemic neuronal cell death. The increased damage was associated with elevations of p-mTOR, p-S6, and p-DRP1; and suppressions of SIRT3 and Nix/BNIP3L. Rapamycin ameliorated diabetes-enhanced ischemic brain damage and reversed the biomarker alterations caused by diabetes. Conclusion High glucose activated mTOR pathway and caused mitochondrial dynamics toward fission. The protective effect of Rapamycin against diabetes-enhanced ischemic brain damage was associated with inhibiting mTOR pathway, redressing mitochondrial dynamic imbalance, and elevating SIRT3 and Nix/BNIP3L expression.
Optimization of redundant degree of freedom in robot milling considering chatter stability
Authors: Liu Yu , Wang Linwei , Yu Ye , Zhang Jinyu , Shu Bin 
Published: February 2022

Abstract
Aiming at the redundant degree of freedom problem of six axis industrial robot performing five axis milling task, a new optimization method of robot milling redundant degrees of freedom considering chatter stability was proposed. Taking the limit cutting depth of robot milling regenerative chatter as the optimization objective, and combined with the constraints of robot motion performance (avoiding joint limit, singular pose and collision), a redundant degree of freedom optimization model considering chatter stability was established. The milling experimental results showed that the new optimization method of robot milling redundant degrees of freedom considering chatter stability proposed in this paper can effectively avoid robot milling regenerative chatter and improve machining quality and efficiency.
New Insights Into the Metabolic Capacity of Gut Microbiota in Coordinating the Efficacy of Mycophenolate Mofetil in Neuromyelitis Optica Spectrum Disorders
Authors: Li Gong , Ren Hao , Xia Lijuan , Ma Xiaoyu , Wei Ran , Wang Xiran , Li Cang , Wang Yuge , He Liming , Sun Jian , Qiu Wei 
Published: February 2022

Abstract
BackgroundMycophenolate mofetil (MMF) has been widely prescribed for the therapy of neuromyelitis optica spectrum disorders (NMOSD) although not all patients display the optimal clinical response to MMF. Our study investigated a potential role of the gut microbiota in the efficacy of MMF in NMOSD patients.MethodsA total of 34 NMOSD patients treated with MMF were prospectively enrolled and grouped according to the therapeutic efficacy as effect group (EG) versus non-effect group (NEG). The gut microbiota was analyzed using 16S rRNA sequencing with stool samples and purine metabolites were profiled in serum samples from the same patients. To further decipher the role of the gut microbiota in coordinating the MMF efficacy, metabolic profiling was performed in microbiota-depleted mice. ResultsThe gut microbiota compositions could not distinguish EG and NEG patients although Clostridium and Synergistetes had significantly increased for EG and this corresponded to a significant decline in abundance of the Coprococcus genus. Additionally, purine salvage pathway (PSP) metabolites inosine, hypoxanthine, xanthine, guanine and uric acid in the serum of NMOSD patients were elevated 2 – 7-fold in the NEG group compared to EG (p< 0.05). We then used the selected PSP metabolites as indicators of MMF efficacy in a mouse model and found that the MMF response was significantly dampened when the gut microbiota was depleted by vancomycin treatment. The latter microbiomes displayed elevated levels of the PSP metabolites xanthine, inosine and hypoxanthine (p< 0.05).ConclusionsThe activity and metabolic capacities of gut microbiomes are essential for efficient response to MMF in NMOSD patients and implies an active role for the gut microbiota in coordinating host responses to MMF therapy.
Development of a screening tool for pregnant women who need social support at obstetric institutions: A prospective cohort study
Authors: Kawaguchi Haruna , Shinohara Ryoji , Akiyama Yuka , Kushima Megumi , Matsuda Yoshio , Yoneyama Marie , Yamamoto Tomomi , Yamagata Zentaro 
Published: February 2022

Abstract
Background
To develop an efficient interview sheet and the screening tool to detect pregnant women in need of social support at obstetric institutions.
Methods
A prospective cohort study was conducted at three medical institutions that were familiar with social issues. The pregnant women were assessed using an interview sheet at the first visit (n = 678), at approximately 28 weeks gestation (n = 495), 36 weeks gestation (n = 296), and the postpartum period (n = 822). We investigated the considered important items on the interview sheet for women in need of social support who were selected based on conferences at three medical institutions. The primary outcome was to develop the available interview sheet during pregnancy and the screening tool to detect pregnant women in need of support to require collaboration with a public health center. The items on the interview sheet were scored by multiple linear regression analysis, and the cutoff values were calculated using the receiver operating characteristic curve. The secondary outcome was to investigate the perinatal factors associated with the Edinburgh postnatal depression scale (EPDS). The association between perinatal factors and EPDS was assessed using multiple logistic regression analyses.
Results
One hundred sixty-six cases for which all interview sheets for all periods were available. Interview sheets and stepwise screening tools during the first and second trimester were developed in which 2.5% of pregnant women were identified as requiring social support, respectively. The factors associated with EPDS ≧ 9 were ‘Women who felt confused/troubled or did not feel anything to be pregnant’ (adjusted odds ratio [aOR]: 6.51, 95% confidence interval [CI]: 1.62–26.15), ‘Maternal mental disorder’ (aOR 4.38; CI 1.06–18.10), ‘Consultation request at first visit’ (aOR 3.22; CI 1.09–9.45), and ‘Women who have difficulty or anxiety about pregnancy during the second trimester’ (aOR 3.14; CI 1.29–7.67).
Conclusions
We created the interview sheets and screening tools for three steps during the first and the second trimester. Future studies are needed to validate these screening tools.
Hypernatremia increases mortality in patients admitted by COVID-19: A Retrospective longitudinal study with 1000 patients
Authors: Wolf Jonas , Berlesi Francine Possebon , Santos Tiane Crestani dos , Glaeser Andressa Barreto , Lunge Vagner Ricardo , Maccari Juçara Gasparetto , Nasi Luiz Antonio 
Published: February 2022

Abstract
Coronavirus disease 2019 (COVID-19) pandemic spread rapidly and this scenario is concerning worldwide. In hospitalized patients, dysnatremia (hyponatremia and/or hypernatremia) is the most common electrolyte disturbance, being reported in 30–40% of cases and associated with a poor prognosis. This retrospective longitudinal study aimed to evaluate the association of dysnatremia with mortality in hospitalized patients infected with COVID-19. We analyzed data from hospital records of 1000 patients with COVID-19 (median age, 62.5 years; 57.1% men), including 109 (10.9%) deaths. Kaplan-Meier survival curves and Cox proportional hazard models with Hazard Ratio (HR) with 95% confidence intervals (95%CI) were applied to confirm the association between dysnatremia (hyponatremia and/or hypernatremia) and death. Hypernatremia was detected in 83 (76.1%) of the patients who died, with a cumulative reduction in survival (p < 0.01) and an increased risk for death by 2.4 fold (95%CI 1.4–2.9). In the multivariable analysis, hypernatremia was the main factor associated with increased mortality (HR:1.50; 95%CI:1.23–1.81). Other factors also associated with death were long length of stay (LOS) (HR:1.54; 95%CI:1.21–1.78), old age (HR:1.63; 95%CI:1.28–1.88), and kidney disease (HR:1.77; 95%CI:1.21–3.30). Hypernatremia during hospitalization is an important risk factor for poor prognosis and an increased risk (2.4) of mortality. LOS, old age, and kidney disease could also be used for risk stratification in patients with COVID-19.