bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical and cognitive function to explain the quality of life among older adults with cognitive impairment: Exploring cognitive function as a mediator
Authors: Rhayun Song , Fan Xing , Seo Jisu 
Published: September 2022

Abstract
Background: Physical and cognitive function are both indicators of aging, characterized by a loss of adaptive response to life challenges and functional limitations subsequently affecting their quality of life. This study aimed to identify the direct effect of physical function and the indirect effect of cognitive function on the quality of life in older adults with mild cognitive impairment.
Methods: The study participants were 79 older adults recruited from community centers in four urban districts of Korea. All participants completed a self-reported questionnaire for demographic characteristics and outcome variables. Outcome measures included physical function (grip strength, balance, and mobility), cognitive function, and mental and physical components of quality of life (QOL). Statistical analyses were conducted using hierarchical multiple linear regression and the PROCESS macro for mediation analysis.
Results: The mean age of participants was 77.46 years old with an elementary or lower education level (53.2%). The mean score of cognitive function was 16.39 (SD=6.5). Physical function (grip strength, balance, mobility) and cognitive function explained 25% of the variance in physical (p=0.004) and 29% in mental (p<0.001) components of QOL after controlling for age, sex, and education level. Mobility was associated with both physical (β=-0.27, p=0.024) and mental (β=-0.36, p=0.002) components of QOL. The cognitive function partially mediated the relationship between balance and the physical component of QOL; the proportion of mediation was 55%.
Conclusions: In conclusion, physical and cognitive function were significant predictors of QOL in older adults with cognitive impairment. Specifically, balance has significant indirect effects on the physical component of QOL through cognitive function as a mediator. Health-promoting strategies could be more effective when focusing on the direct effect of physical function as well as the mediating effect of cognitive function to promote the quality of life in this population.
Comparison of Walkability of Commercial Arteries by Using PEDS Tool. Case from Northern Cyprus
Authors: Darwich Mohammad , Kara Can 
Published: September 2022

Abstract
The aim of this study is to conduct a comparative study on walkability using both streamlines. Two popular streets in North Cyprus, Ismet Inonu Boulevard in Famagusta and Osman Pasha Street in Nicosia are selected for this study. To fulfill the aim of the study, mix-method approach is used. In the qualitative phase of the study, Pedestrian Environment Data Scan (PEDS) is exploited. This tool directs observation through several items. The quantitative phase is performed by proposing a model of walkability considering different dimensions suggested in the literature. The questionnaire survey was conducted on both streets separately and the model is evaluated. All constructs of the proposed model are confirmed and then used to statistically compare street walkability dimensions in the case studies. A comparative study of these streets in terms of walkability helped in understanding the weaknesses and strengths of the designs and led to guidelines for intervention and modification to improve street walkability and encourage people to walk more.
Meta-QTL Analysis and Identification of Candidate Genes for Spot Blotch Resistance in Bread Wheat
Authors: Sharma Vaishali , Vasistha Neeraj Kumar 
Published: September 2022

Abstract

In bread wheat, a meta-QTL (MQTL) analysis was conducted using 275 QTLs that were available from 24 earlier studies and 275 QTLs were identified from all these studies of QTLs analysis. A dense consensus map comprising 73788 molecular markers. These 275 QTLs resulted 22 MQTLs, which were found on 15 of the 21 chromosomes (excluding 1D, 3D, 4A, 5D, 6B, and 6D). MQTLs Composite interval (CI) ranged from maximum 0.0 to maximum 422.9 cM. Furthermore, 11 MQTLs out of the 22 MQTLs affected more than one feature, demonstrating their pleiotropic nature. The following four MQTLs were significant among these 11 MQTLs: (1) MQTL14, MQTL15, MQTL21 and MQTL22 which were the major MQTL located on chromosome 5B and 7D with PVE 17.12% and 10.5% and mean PVE % for individual MQTLs ranged from 4.0–19% with their CI ranging from 0.0 cM (MQTL1) to 422.8 cM (MQTL22). Each MQTL exhibits a unique set of features such as stay green, wheat flag leaf senescence, green leaf area duration, green leaf area of main stem, and all the above resistance to spot blotch. MQTL2, MQTL3, MQTL10, and MQTL13 were shown to have a variety of features at one locus, demonstrating a close relationship between these characters. In present study, we found two major spot blotch resistance genes,Sb1andSb2, with QTLs shownQsb.bhu-5B, Qsb.pau-5B, Qsb.bhu-7D, QTs-7D, andQTs-7D. We had also found other QTLs those were associated with spot blotch resistance. These QTLs wereQGlnms20-5B,QSG.qgw-5B,QGlad25-5B, QTmrs-5B, andQTs-7D. Total 2509 unique CGs have been identified in the genomic areas of 22 MQTLs. These CGs encoded approximately 503 proteins in which the role of 412 protein have already been established in the resistance to several biotic stresses. The differential expression of candidate genes were measured on the basis of fold change value and found the maximum 5.4-fold change for positive regulation and − 5 FC value for the negative regulation. These genes were encoding proteins from the following classes: Proteins with a R domain, Transcription factors (Zn finger binding proteins, SANT/Myb domains, NAC domain, BTF3), Sugar phosphate transporter domain, Zinc finger C2H2-type, Protein kinase domain, DEP domain, NB-ARC, Leucine-rich repeat domain superfamily, AAA + ATPase domain.
Activity of Decitabine (DEC) Combined with All-Trans Retinoic Acid (ATRA) in oligoblastic AML: Results from a Randomized 2x2 Phase II Trial (DECIDER)
Authors: Rummelt Christoph , Grishina Olga , Schmoor Claudia , Crysandt Martina , Heuser Michael , Götze Katharina S. , Schlenk Richard F. , Döhner Konstanze , Salih Helmut R. , Heil Gerhard , Müller-Tidow Carsten , Brugger Wolfram , Kündgen Andrea , Wit Maike , Giagounidis Aristoteles , Scholl Sebastian , Neubauer Andreas , Krauter Jürgen , Bug Gesine , Al-Ali Haifa Kathrin , Wäsch Ralph , Becker Heiko , May Annette M. , Duyster Justus , Hackanson Björn , Ganser Arnold , Döhner Hartmut , Lübbert Michael 
Published: September 2022

Abstract
DNA-hypomethylating agents are the backbone for non-intensive combination treatments of AML/MDS. In elderly AML patients, a combination of DEC+ATRA resulted in an improved response rate and survival compared to DEC without ATRA, also in those with prior hematologic disorder; additional valproic acid did not play a significant role (Lübbert et al., JCO 2020). To evaluate whether patients with oligoblastic AML also benefit from this combination, patients from the DECIDER cohort with 20-30% bone marrow blasts were analyzed for clinical outcome in this exploratory, not pre-planned subgroup analysis. They were newly diagnosed with AML, were unfit for induction and received DEC 20 mg/m2 day 1-5 in all arms, ATRA day 6-28 (arms C/D) and VPA p.o. continuously from day 6 (arms B/D) of each 28-day course. 200 patients were randomized and treated, 56 with oligoblastic AML. Of these, six attained a CR, 7 a CRi, and 1 a PR, resulting in an ORR of 25%. The effect on ORR of ATRA vs no ATRA was 31.8 vs 20.6% with an odds ratio of 1.85 (95% CI 0.54-6.37, p=0.33). With 48 deaths out of 56 patients, median OS was 9.1 months. The effect on OS of ATRA vs. no ATRA was 11.5 vs 7.6 months with a HR of 0.71 (95% CI 0.40-1.29, p=0.26). In elderly patients with oligoblastic AML ineligible for induction chemotherapy, the addition of ATRA to DEC resulted in a clinically meaningful survival benefit. We hypothesize that the combination of an HMA with a retinoid may also be active in MDS with excess blasts.
IL13 and periostin in active fibrogenic areas of the extrahepatic bile ducts in biliary atresia patients
Authors: Sengoku Yuki , Higashi Mayumi , Nagayabu Kazuya , Takayama Shohei , Fumino Shigehisa , Aoi Shigeyoshi , Furukawa Taizo , Tajiri Tatsuro 
Published: September 2022

Abstract
Background: The leading pathology of biliary atresia (BA) is inflammatory and fibrous obstruction of extrahepatic bile duct, butthe pathogenesis remains unclear.IL13 is a cytokine associated with allergies and inflammatory fibrosis, and periostin induces fibrogenesis by stimulation with IL13. We analyzed the involvement of IL13 and periostin in inflammatory fibrosis in the extrahepatic bile duct of BA patients.
Materials and Methods: Surgically resected tissues from the hepatic hilar area of BA patients were immunostained with CD45, α-SMA, IL13 and periostin and statistically analyzed. Fibroblasts from the resected tissue were cultured with recombinant IL13, and periostin production was analyzed by quantitative polymerase chain reaction and Western blotting.
Results: IL13 was stained in 93% of large and micro bile ducts, and 92.1% matched with the CD45 location (p=0.006) around the large bile ducts. Periostin staining correlated with the localization of IL13 and αSMA (p<0.001) around the large bile ducts. Periostin mRNA and protein were up regulated by IL13 stimulation in cultured fibroblasts.
Conclusion: IL13 was associated with induced periostin expression by fibroblasts, playing a vital role in the pathogenesis of fibrogenesis around the extrahepatic bile duct in BA.
A Comparison of invasive arterial blood pressure measurement with oscillometric non-invasive blood pressure measurement in patients with sepsis
Authors: Jiang Ziqing , Li Shaoying , Lin Wang , Yu Feng , Zeng Yanping , Li Hongbo , Li Jun , Zhang Zhanfeng , Zuo Junling 
Published: September 2022

Abstract
Background
Multiple studies had investigated the discrepancies of different blood pressure monitoring techniques in critical patients, but it remained controversial in patients with sepsis. This study aimed to compare non-invasive oscillometric blood pressure (NIBP) measurement with invasive arterial blood pressure (IBP) measurement in patients with sepsis.
Methods
We conducted a retrospective study to evaluate the agreement between IBP and NIBP using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Paired blood pressure measurements of mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were compared using Bland-Altman analysis and paired Student’s t-test. We also focus on the effect of NE on the agreement between the two methods and the association between blood pressure and mortality during intensive care unit (ICU) stay.
Results
A total of 96,673 paired blood pressure measurements from 6,060 unique patients were analyzed in the study. In Bland-Altman analysis, the bias (± SD, 95% limits of agreement) was 6.21mmHg (± 12.05mmHg, -17.41 to 29.83mmHg) for MAP, 0.39mmHg (± 19.25mmHg, -37.34 to 38.12mmHg) for SBP, and 0.80mmHg (± 12.92mmHg, -24.52 to 26.12mmHg) for DBP between the two techniques. Similarly, large limits of agreement were shown in different groups of NE doses. NE doses significantly affected the agreement between IBP and NIBP. SBP between the two methods gave an inconsistent assessment of patients’ risk of ICU mortality.
Conclusion
IBP and NIBP were not interchangeable in septic patients. Clinicians should be aware that non-invasive MAP was clinically and significantly underestimated invasive MAP.
Coding Complexity Cost and the Optimal Number of Bases
Authors: Kak Subhash 
Published: September 2022

Abstract
The question of efficient coding of information for engineered and natural systems is connected both with the use of applicable probability distribution and assignment of appropriate dimensionality with the data. When the cost of coding of data or that of classes increases linearly with the number of bases, ternary coding is superior to binary, and coding in e is optimal. This paper investigates the relative efficiency of bases for the cases when the cost complexity is affine (slope-intercept linear) or exponential. The affine cases for which binary and ternary bases are optimal are presented. Noninteger number of bases imply self-similarity and, therefore, this study forms a bridge to the use of the Newcomb-Benford distribution in a variety of applications.
Viability of Pressure Reducing Valves for Leak Reduction in Water Distribution Systems
Authors: Jones Frederick , Barkdoll Brian 
Published: September 2022

Abstract
Since water distribution systems are so important to public health and many are leaking in unknown locations, a modeling study was performed to investigate the feasibility of installing pressure reducing valves (PRVs) in various locations throughout several systems. A PRV was tried in each pipe, one by one, and the total cost (energy costs plus opportunity costs of losing water that could have been sold) calculated. It was found that installing a PRV in the upstream pipes reduced costs the most and that putting a PRV in some pipes actually lost money due to the high cost of the PRV and associated fittings. Also, a PRV on the upstream portion of a large branch saved water leakage. Energy is saved when a PRV is placed near a pump for systems with high energy consumption.
Facilitated Ureteroscopy with DJ stent implantation in Ureterolithiasis- insights from a retrospective study
Authors: Lidawi Ghalib , Fanne Rami Abu , Majdoub Muhammad , Asali Mohsin , Zeina Abdel-Rauf , Rub Ronen 
Published: September 2022

Abstract
Objective: We aimed to investigate the role of upstream Double J-stent insertion on surgical outcomes of retrograde semi-rigid ureteroscopy in patients with upper ureter stones.
Materials and methods: In this retrospective study, we analyzed 290 patients who underwent retrograde semi-rigid ureteroscopy (URS) for upper ureter stones between April 2018 and September 2019. Patients were divided into two groups: delayed primary URS, and upstream, preoperative DJ stent placement URS group (using DJ stent). Operation time, postoperative hospital stay, complications, stone-free rate and risk for repeat operation and requisites for postoperative DJ stent were measured for each patient after ureteroscopy.
Results: The median age in the DJ stented and non-stented groups was 49.1±14.3 and 46.4±13 years, respectively (p=0.11). Stone laterality, the proportion of male patients, and urinary tract infection prevalence were comparable between the groups. The median operation time was 15.5±7 min vs. 16±8.7 min (p=0.89), and stone-clearance rate was 95% vs. 88.8 % (p=0.12). Impressively, the need for "rescue" DJ stenting at the end of initial ureteroscopy (27.7% and 54%, respectively, P<0.001), the duration of postoperative indwelling DJ stenting (11.7 vs. 16.4 days, P<0.001, respectively), and the need for redo ureteroscopy (3.75% vs. 11.9%, P<0.03) were all significantly lower in the upstream DJ group.
Conclusion: facilitated semi-rigid ureteroscopy with upstream DJ stenting for small and medium size ureteral stones has favorable periprocedural outcomes compared with primary ureteroscopy. Therefore, it seems prudent to preoperatively insert DJ stent whenever ureteroscopy is considered for ureteral stones.
Barriers to women's participation, leadership, and empowerment in community-managed water and sanitation in rural Bolivia
Authors: Hamlet Leigh , Gutierrez V. B. , Soto A. , Dickin S. 
Published: September 2022

Abstract
Enabling women to be meaningful participants and leaders in rural community-based water and sanitation governance remains a challenge. While the benefits of and barriers to women's participation and leadership have been reported on, there is limited understanding of the role of empowerment in addressing these challenges. To help bridge this knowledge gap, we used a household survey to measure men and women's empowerment in water and sanitation in the rural Tupiza watershed, Bolivia, and key informant interviews with women leaders to identify barriers to leadership. Overall, among survey respondents, fewer men than women were disempowered. Community-level factors, especially those related to comfort in speaking in community meetings and reporting service problems, contributed more to women's disempowerment, as did household-level factors related to work balance and input into decisions about who participates in community water and sanitation activities. Among interviewed community water leaders, many women felt their positions were costly to their households and reported challenges in obtaining technical training and local government assistance, which not only disempowered them as leaders but also was likely tied to poor service delivery and related health outcomes in their communities. We discuss the implications of our findings for rural Bolivia and future research opportunities.
The Therapeutic Potential of Mitochondria Transplantation Therapy in
Neurodegenerative and Neurovascular Disorders
Authors: Khan Mohammad Moshahid , Paez Hector G. , Pitzer Christopher R. , Alway Stephen E. 
Published: September 2022

Abstract:
Neurodegenerative and neurovascular disorders affect millions of people worldwide and account for a large and increasing health burden on the general population. Thus, there is a critical need to identify potential disease-modifying treatments that can prevent or slow the disease progression. Mitochondria are highly dynamic organelles and play an important role in energy metabolism and redox homeostasis, and mitochondrial dysfunction threatens cell homeostasis, perturbs energy production, and ultimately leads to cell death and diseases. Impaired mitochondrial function has been linked to the pathogenesis of several human neurological disorders. Given the significant contribution of mitochondrial dysfunction in neurological disorders, there has been considerable interest in developing therapies that can attenuate mitochondrial abnormalities and proffer neuroprotective effects. Unfortunately, therapies that target specific components of mitochondria or oxidative stress pathways have exhibited limited translatability. To this end, mitochondrial transplantation therapy (MTT) presents a new paradigm of therapeutic intervention, which involves the supplementation of healthy mitochondria to replace the damaged mitochondria for the treatment of neurological disorders. Prior studies demonstrated that the supplementation of healthy donor mitochondria to damaged neurons promotes neuronal viability, activity, and neurite growth and has been shown to provide benefits for neural and extra-neural diseases. In this review, we discuss the significance of mitochondria and summarize an overview of the recent advances and development of MTT in neurodegenerative and neurovascular disorders, particularly Parkinson’s disease, Alzheimer’s disease, and stroke. The significance of MTT is emerging as they meet a critical need to develop a disease-modifying intervention for neurodegenerative and neurovascular disorders.
A 405 nm Photodetector Based on the CsPbBr3-CsPb2Br5 Compound Thin
Film
Authors: Xie Qingshuang , Liu Xing , Guan Lin 
Published: September 2022

Aims:
This work reported a 405 nm photodetector based on the thermal evaporated CsPbBr3-CsPb2Br5 compound thin film.

Background:
The post-annealing process of the CsPbBr3-CsPb2Br5 compound thin film prepared by thermal evaporation method has been improved in this work. To enhance the crystallization and photoresponse properties of the thin films, dimethyl sulfoxide (DMSO) steam was used in post-annealing process, instead of using the previous way that increased the annealing temperature.

Methods:
The CsPbBr3-CsPb2Br5 compound powder was deposited directly on surface glass substrate by thermal evaporation to form CsPbBr3-CsPb2Br5 compound thin film. The thin films were post-annealed at 150 oC for 15 min to crystallize. The DMSO liquid was dropped on the substrate, and then the liquid would be evaporated completely to become DMSO steam during 150 oC post-annealing. The DMSO steam would cover the thin film completely to help the crystallization. Finally, the gold electrodes were deposited on surface of thin films with a conductive channel of 1 mm * 100 µm.

Result:
Results showed that the crystalline quality of the thin film after DMSO steam annealing was greatly improved compared with that of thin film without DMSO steam annealing. The energy gap was between 2.355 eV and 2.293 eV, which was similar to the previous report. In addition, under 405 nm excitation, the photocurrent of the thin film annealed in DMSO steam showed the rapid response (35 ms), good light radiation power dependence of the photocurrent and the improved responsivity. Especially, the responsivity at 3 V bias of the thin film annealed in DMSO steam increased to 1.5 times that of the thin film without DMSO steam annealing and even 4.5 times that of as-deposited film.

Conclusion:
A 405 nm photodetector based on the thermal evaporated CsPbBr3-CsPb2Br5 compound thin film was prepared successfully. The newest report has improved the preparation process of CsPbBr3-CsPb2Br5 compound thin films, where low annealing temperature with the DMSO steam assisted post-annealing process was used. The thin film annealed in DMSO steam possesses high crystalline quality and enhanced photoresponse performances, compared with thin film without DMSO steam annealing.
Anatomi Keragaman Batang Gyrinops versteegii (Thymelaeaceae) di Pulau Sumbawa (Stem diversity of Gyrinops versteegii (Thymelaeaceae) in Sumbawa Island
Authors: Mulyaningsih Tri , Muspiah Aida , Sany Zainul Muttaqin 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui anatomi komparatif batang pada Gyrinops versteegii (Thymelaeaceae) di Pulau Sumbawa. Sampel batang pohon gaharu G. versteegii yang digunakan merupakan koleksi dari Laboratorium Pusat Kajian Gaharu FMIPA Universitas Mataram yang diambil dari Pulau Sumbawa. Pembuatan preparat menggunakan metode permanen dengan pengirisan menggunakan free hand section, dan metode maserasi. Data yang diamati meliputi jaringan korteks, xilem , empulur, dan keristal Ca-Oksalat. Hasil penelitian diketahui bahwa ditemukan empat provenan Gyrinops versteegii di Pulau Sumbawa yakni provenan Pantai, Hajumee, Kayuk pisak dan provenan baru (provenan Tartar). Komparasi anatomi antara batang G. versteegii provenan Pantai dengan provenan lainnya memiliki perbedaan pada tebal periderm, bentuk jaringan sklerenkim, tebal interxylary phloem, diameter parenkim korteks, jumlah barisan jaringan parenkim kayu, diameter trakeida, diameter sel empulur, bentuk Ca-oxalat. Provenan Hajumee dengan Tartar dan Kayuk pisak berbeda pada panjang trakea, diameter trakea, dan panjang trakeida, sedangkan provenan Tartar dan Kayuk pisak berbeda pada frekuensi trakea, panjang trakeid serabut, susunan jari-jari empulur, dan letak empulur.