bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rough singular integrals associated to polynomial curves
Authors: Zhang Yulin , Liu Feng 
Published: January 2022

AbstractIn this paper, the authors establish the boundedness of singular integral operators associated to polynomial curves as well as the related maximal operators with rough kernels $\Omega \in H^{1}({\mathrm{S}}^{n-1})$
Ω
∈

H
1

(

S

n
−
1

)
and $h\in \Delta _{\gamma }(\mathbb{R}_{+})$
h
∈

Δ
γ

(

R
+

)
for some $\gamma >1$
γ
>
1
on the Triebel–Lizorkin spaces. It should be pointed out that the bounds are independent of the coefficients of the polynomials in the definition of the operators. The main results of this paper not only improve and generalize essentially some known results but also complement some recent boundedness results.
Stabilization of stochastic regime-switching Poisson jump equations by delay feedback control
Authors: Li Guangjie 
Published: January 2022

AbstractThis paper is concerned with the stabilization of stochastic regime-switching Poisson jump equations (also known as stochastic differential equations with Markovian switching and Poisson jumps, abbreviated as SDEwMJs). The aim of this paper is to design a feedback controller with delay δ ($\delta >0$
δ
>
0
) to make an unstable SDEwMJ become stable. It is proved that the delay δ is bounded by a constant δ̄. Moreover, an implicit lower bound for $\bar{\delta ,}$

δ
,

¯

which can be computed numerically, is provided. As a product, the almost sure exponential stability of the controlled SDEwMJ is obtained. Besides, an example is given to demonstrate the theoretical results.
Dual-plane coupled phase retrieval for non-prior holographic imaging
Authors: Huang Zhengzhong , Memmolo Pasquale , Ferraro Pietro , Cao Liangcai 
Published: January 2022

AbstractAccurate depiction of waves in temporal and spatial is essential to the investigation of interactions between physical objects and waves. Digital holography (DH) can perform quantitative analysis of wave–matter interactions. Full detector-bandwidth reconstruction can be realized based on in-line DH. But the overlapping of twin images strongly prevents quantitative analysis. For off-axis DH, the object wave and the detector bandwidth need to satisfy certain conditions to perform reconstruction accurately. Here, we present a reliable approach involving a coupled configuration for combining two in-line holograms and one off-axis hologram, using a rapidly converging iterative procedure based on two-plane coupled phase retrieval (TwPCPR) method. It realizes a fast-convergence holographic calculation method. High-resolution and full-field reconstruction by exploiting the full bandwidth are demonstrated for complex-amplitude reconstruction. Off-axis optimization phase provides an effective initial guess to avoid stagnation and minimize the required measurements of multi-plane phase retrieval. The proposed strategy works well for more extended samples without any prior assumptions of the objects including support, non-negative, sparse constraints, etc. It helps to enhance and empower applications in wavefront sensing, computational microscopy and biological tissue analysis.
Advanced epithelial lung and gut barrier models demonstrate passage of microplastic particles
Authors: Donkers Joanne M. , Höppener Elena M. , Grigoriev Ilya , Will Lena , Melgert Barbro N. , van der Zaan Bas , van de Steeg Evita , Kooter Ingeborg M. 
Published: January 2022

AbstractMicro- and nanoplastics (MNP) can be found virtually everywhere around us in the biosphere and food chain, therefore humans are continuously exposed to MNP, mainly via inhalation and ingestion. Here, we have applied physiologically relevant human-based advanced in vitro models representing the lung (MucilAir™) and gut (InTESTine™ and Intestinal Explant Barrier Chip (IEBC)) to study membrane passage of various MNP and their potency to induce cytotoxic effects, barrier disturbances or pro-inflammatory cell activation. Selected MNP of various materials (polystyrene, polyethylene, nylon, car tire, and marine MNP collected from the ocean), shapes (spheres, fragments and fibers), sizes (0.05–100 μm), some of which were fluorescently labelled for tracking, were included. Without affecting cell viability, nylon fibers and (cleaned) HDPE (high density polyethylene) disrupted the MucilAir™ epithelial barrier. Luminal exposure to polystyrene particles (1 and 10 μm) and pristine HDPE fragments significantly decreased human colon tissue functionality. Furthermore, all polystyrene particles (0.05, 1 and 10 μm) affected tissue viability in porcine jejunum, ileum and colon tissue after 5 h exposure, and this was further confirmed in the IEBC after 24 h of exposure to 10 μm polystyrene particles and nylon fibers. Exposure to nylon fibers and its supernatant led to pro-inflammatory cell activation, as shown by increased IL-6 release in MucilAir™ and in human colon tissue after 96 or 24 h, respectively. Regarding transepithelial penetration of the MNP, permeability of 0.05 μm polystyrene spheres in the MucilAir™ lung cell model reached 3.6 ± 1.2% after 24 h. With 3.37 ± 0.46% after 5 h under static conditions and 5.5 ± 1.3% after 24 h under microfluidic conditions MNP permeability across intestinal tissue was highest for the largest (10 μm) polystyrene spheres. Confocal microscopy confirmed the translocation of MNP across the lung and intestinal epithelial barrier. In conclusion, we present a study revealing the passage of MNP over the epithelium of advanced in vitro models for the lung and intestine barrier. Furthermore, pro-inflammatory cell activation and disrupted barrier integrity were observed after exposure to several of the tested MNP. Future research is needed to further identify the effects of shape, size and material on these processes and subsequently the health effects of humans.
Neoadjuvant Atezolizumab With Gemcitabine and Cisplatin in Patients With Muscle-Invasive Bladder Cancer: A Multicenter, Single-Arm, Phase II Trial
Authors: Funt Samuel A. , Lattanzi Michael , Whiting Karissa , Al-Ahmadie Hikmat , Quinlan Colleen , Teo Min Yuen , Lee Chung-Han , Aggen David , Zimmerman Danielle , McHugh Deaglan , Apollo Arlyn , Durdin Trey D. , Truong Hong , Kamradt Jeffrey , Khalil Maged , Lash Bradley , Ostrovnaya Irina , McCoy Asia S. , Hettich Grace , Regazzi Ashley , Jihad Marwah , Ratna Neha , Boswell Abigail , Francese Kaitlyn , Yang Yuanquan , Folefac Edmund , Herr Harry W. , Donat S. Machele , Pietzak Eugene , Cha Eugene K. , Donahue Timothy F. , Goh Alvin C. , Huang William C. , Bajorin Dean F. , Iyer Gopa , Bochner Bernard H. , Balar Arjun V. , Mortazavi Amir , Rosenberg Jonathan E. 
Published: January 2022

PURPOSE Neoadjuvant gemcitabine and cisplatin (GC) followed by radical cystectomy (RC) is standard for patients with muscle-invasive bladder cancer (MIBC). On the basis of the activity of atezolizumab (A) in metastatic BC, we tested neoadjuvant GC plus A for MIBC. METHODS Eligible patients with MIBC (cT2-T4aN0M0) received a dose of A, followed 2 weeks later by GC plus A every 21 days for four cycles followed 3 weeks later by a dose of A before RC. The primary end point was non–muscle-invasive downstaging to < pT2N0. RESULTS Of 44 enrolled patients, 39 were evaluable. The primary end point was met, with 27 of 39 patients (69%) < pT2N0, including 16 (41%) pT0N0. No patient with < pT2N0 relapsed and four (11%) with ≥ pT2N0 relapsed with a median follow-up of 16.5 months (range: 7.0-33.7 months). One patient refused RC and two developed metastatic disease before RC; all were considered nonresponders. The most common grade 3-4 adverse event (AE) was neutropenia (n = 16; 36%). Grade 3 immune-related AEs occurred in five (11%) patients with two (5%) requiring systemic steroids. The median time from last dose of chemotherapy to surgery was 7.8 weeks (range: 5.1-17 weeks), and no patient failed to undergo RC because of AEs. Four of 39 (10%) patients had programmed death-ligand 1 (PD-L1)–positive tumors and were all < pT2N0. Of the patients with PD-L1 low or negative tumors, 23 of 34 (68%) achieved < pT2N0 and 11 of 34 (32%) were ≥ pT2N0 ( P = .3 for association between PD-L1 and < pT2N0). CONCLUSION Neoadjuvant GC plus A is a promising regimen for MIBC and warrants further study. Patients with < pT2N0 experienced improved relapse-free survival. The PD-L1 positivity rate was low compared with published data, which limits conclusions regarding PD-L1 as a predictive biomarker.
Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration
Authors: Kapuria Subir , Bai Haipeng , Fierros Juancarlos , Huang Ying , Ma Feiyang , Yoshida Tyler , Aguayo Antonio , Kok Fatma , Wiens Katie M. , Yip Joycelyn K. , McCain Megan L. , Pellegrini Matteo , Nagashima Mikiko , Hitchcock Peter F. , Mochizuki Naoki , Lawson Nathan D. , Harrison Michael M. R. , Lien Ching-Ling 
Published: January 2022

ABSTRACT
Endothelial cells emerge from the atrioventricular canal to form coronary blood vessels in juvenile zebrafish hearts. We find that pdgfrb is first expressed in the epicardium around the atrioventricular canal and later becomes localized mainly in the mural cells. pdgfrb mutant fish show severe defects in mural cell recruitment and coronary vessel development. Single-cell RNA sequencing analyses identified pdgfrb+ cells as epicardium-derived cells (EPDCs) and mural cells. Mural cells associated with coronary arteries also express cxcl12b and smooth muscle cell markers. Interestingly, these mural cells remain associated with coronary arteries even in the absence of Pdgfrβ, although smooth muscle gene expression is downregulated. We find that pdgfrb expression dynamically changes in EPDCs of regenerating hearts. Differential gene expression analyses of pdgfrb+ EPDCs and mural cells suggest that they express genes that are important for regeneration after heart injuries. mdka was identified as a highly upregulated gene in pdgfrb+ cells during heart regeneration. However, pdgfrb but not mdka mutants show defects in heart regeneration after amputation. Our results demonstrate that heterogeneous pdgfrb+ cells are essential for coronary development and heart regeneration.
Centrosome maturation – in tune with the cell cycle
Authors: Blanco-Ameijeiras Jose , Lozano-Fernández Pilar , Martí Elisa 
Published: January 2022

ABSTRACT
Centrosomes are the main microtubule-organizing centres, playing essential roles in the organization of the cytoskeleton during interphase, and in the mitotic spindle, which controls chromosome segregation, during cell division. Centrosomes also act as the basal body of cilia, regulating cilium length and affecting extracellular signal reception as well as the integration of intracellular signalling pathways. Centrosomes are self-replicative and duplicate once every cell cycle to generate two centrosomes. The core support structure of the centrosome consists of two molecularly distinct centrioles. The mother (mature) centriole exhibits accessory appendages and is surrounded by both pericentriolar material and centriolar satellites, structures that the daughter (immature) centriole lacks. In this Review, we discuss what is currently known about centrosome duplication, its dialogue with the cell cycle and the sequential acquisition of specific components during centriole maturation. We also describe our current understanding of the mature centriolar structures that are required to build a cilium. Altogether, the built-in centrosome asymmetries that stem from the two centrosomes inheriting molecularly different centrioles sets the foundation for cell division being an intrinsically asymmetric process.
Design of Dimeric Dinuclear Boron Complexes with Flexible Linkers: Aggregation-induced White-light Emission via Molecular Engineering
Authors: Ihara Megumi , Cui Luxia , Konishi Yuto , Hisaeda Yoshio , Ono Toshikazu 
Published: January 2022

Abstract
The aggregation state of two new covalently bonded dinuclear boron-based dye complexes was controlled to fabricate white-light-emitting materials. The materials exhibit blue and orange emission, with a photoluminescence quantum yield of 16% for one of the complexes in the solid state. This study highlights the importance of molecular engineering through the control of dye aggregation as a fundamental technology for creating novel functional materials with interesting optical properties.
Cu- or Fe-catalyzed Atom-Transfer Radical Reactions in Cyclizations
Authors: Matsumoto Junki , Nakashima Yusei , Nishikata Takashi 
Published: January 2022

Abstract
Herein, we report an efficient method using transition metal catalysts for controlling atom-transfer radical cyclization elimination (ATRCE) and atom-transfer radical cyclization (ATRC) in the reaction of α-bromocarbonyls possessing a styrene moiety. An iron salt efficiently catalyzed the ATRCE to produce cyclic compounds possessing a C-C double bond. On the other hand, the copper catalyst produced halogenated cyclic compounds.
Factors associated with research productivity in higher education institutions in Africa: a systematic review
Authors: Uwizeye Dieudonne , Karimi Florah , Thiong'o Caroline , Syonguvi Jackline , Ochieng Vollan , Kiroro Francis , Gateri Alex , Khisa Anne M. , Wao Hesborn 
Published: January 2022

Background: There are low levels of research productivity among Higher Education Institutions (HEIs) in Africa, a situation that is likely to compromise the development agenda of the continent if not addressed. We conducted a systematic literature review to synthesize evidence of the factors associated with research productivity in HEIs in Africa and the researchers’ motives for research. Methods: We identified 838 publications related to research productivity in HEIs in Africa from various databases, from which we included 28 papers for review. The inclusion criteria were that (i) the paper’s primary focus was on factors associated with research productivity, and motivations of doing research among faculty members in Africa; (ii) the setting was the HEIs in Africa; (iii) the type of publication was peer-reviewed papers and book chapters based on primary or secondary data analysis; and (iv) the language was English or French. Essays, opinions, blogs, editorials, reviews, and commentaries were excluded. Results: Most of the studies operationalized research productivity as either journal publications or conference proceedings. Both institutional and individual factors are associated with the level of research productivity in HEIs in Africa. Institutional factors include the availability of research funding, level of institutional networking, and the degree of research collaborations, while individual factors include personal motivation, academic qualifications, and research self-efficacy. Conclusions: Deliberate efforts in HEIs in Africa that addressed both individual and institutional barriers to research productivity are promising. This study recommends that the leadership of HEIs in Africa prioritizes the funding of research to enable researchers to contribute to the development agenda of the continent. Moreover, HEIs should build institutional support to research through the provision of research enabling environment, policies and incentives; strengthening of researchers’ capabilities through relevant training courses, mentorship and coaching; and embracing networking and collaboration opportunities.
Knowledge, attitude, and practices associated with avian influenza among undergraduate university students of East Java Indonesia: A cross-sectional survey
Authors: Rehman Saifur , Rantam Fedik Abdul , Batool Khadija , Rahman Attaur , Effendi Mustofa Helmi , Rahmahani Jola , Jamal Muhsin 
Published: January 2022

Background: Several public health strategic actions are required for effective avian influenza (AI) prevention and control, as well as the development of a communication plan to keep undergraduate students sufficiently informed on how to avoid or reduce exposure. The aim of the survey was to measure the level of knowledge, attitudes and practices (KAPs) toward AI among undergraduate university students in East Java, Indonesia, and observe the correlation between KAPs and the factors associated with the control and prevention of AI. Methods: A cross-sectional survey was conducted among undergraduate students to collect information about AI-related KAPs. Students were selected from three faculties of Universitas Airlangga Surabaya Indonesia (Faculty of Veterinary Medicine, Faculty of Fisheries and Marine, and Faculty of Science and Technology). Students voluntarily responded to a pre-designed questionnaire. Results: A total of 425 students (222 female; and 203 male), of ages ranging from 18 years (n=240) to 20-30 years (n=185), responded to the survey. This cohort consisted of 157 students from the Faculty of Fisheries and Marine, 149 from the Faculty of Veterinary Medicine, and 119 from the Faculty of Science and Technology. The results indicated that appropriate knowledge was obtained by 76.94% of students; significantly higher levels were seen in Faculty of Veterinary Medicine students as compared to the other two faculties (p<0.05). 72.89% of students documented positive attitudes; veterinary medicine students had significantly more positive attitudes than other faculties (p<0.05). Proactive behaviors were observed in 56.90% of students. The aggregate scores for KAPs were 6.93 ± 0.77 (range: 0-9) for knowledge, 7.6 ± 1.25 (range: 0-10) for attitude, and 9.1 ± 1.5 (range: 0-12) for practice.
Knowledge on hypertension in Myanmar: levels and groups at risk
Authors: Pardoel Zinzi E. , Lensink Robert , Postma Maarten , Win Hla Hla , Swe Khin Hnin , Stein Claire , Febrinasari Ratih , My Hanh Hoang , Koot Jaap A.R. , Landsman Johanna A. , Reijneveld Sijmen A. 
Published: January 2022

Background: Non-communicable diseases, specifically the burden of hypertension, have become a major public health threat to low- and middle-income countries, such as Myanmar. Inadequate knowledge of hypertension and its management among people may hinder its effective prevention and treatment with some groups at particular increased risks, but evidence on this is lacking for Myanmar. The aims of this study were therefore to assess the level of knowledge of risk factors, symptoms and complications of hypertension, by hypertension treatment status, community group-membership, and sociodemographic and socioeconomic factors in Myanmar. Methods: Data was collected through structured questionnaires in 2020 on a random sample of 660 participants, stratified by region and existence of community groups. Knowledge of hypertension was measured with the ‘Knowledge’ part of a validated ‘Knowledge, Attitude and Practice’ survey questionnaire and categorised into ill-informed and reasonably to well-informed about hypertension. Results: The majority of respondents were reasonably to well-informed about risk factors, symptoms and complications of hypertension. This did not vary by hypertension treatment status and community group membership. People with jobs (B=0.96; 95%-confidence interval 0.343 to 1.572) and higher education (B=1.96; 0.060 to 3.868) had more hypertension knowledge than people without jobs or low education. Adherence to treatment among hypertensive people was low. Conclusion: This study shows a majority of participants in Myanmar to be reasonably to well-informed, with no differences by hypertension status, treatment status, and community group-membership. People without jobs and low education have less hypertension knowledge and almost half of the hypertensive patients did not take their medicines, making them priority groups for tailored education on health care level as well as community level, lowering the burden of hypertension. Therefore, adherence to treatment of hypertension should be an important element for future health education.
Single nucleotide polymorphism (SNP) in the doublesex (dsx) gene splice sites and relevance for its alternative splicing in the malaria vector Anopheles gambiae
Authors: Djihinto Oswald , Saizonou Helga D.M. , Djogbenou Luc S. 
Published: January 2022

Background: The malaria burden continues to be significant in tropical regions, and conventional vector control methods are faced with challenges such as insecticide resistance. To overcome these challenges, additional vector control interventions are vital and include modern genetic approaches as well as classical methods like the sterile insect technique (SIT). In the major human malaria vector Anopheles gambiae, a candidate gene favourable for sterility induction is the doublesex (dsx) gene, encoding somatic sexually dimorphic traits in mosquitoes. However, the mechanism that regulates the expression of this gene in anopheline mosquitoes is poorly understood. This study aimed to screen the An. gambiae dsx gene splice site sequences for single nucleotide polymorphisms (SNPs) that could be critical to its alternative splicing. Methods: Variant annotation data from Ag1000G project phase 2 was analysed, in order to identify splice-relevant SNPs within acceptor and donor splice sites of the An. gambiae dsx gene (Agdsx). Results: SNPs were found in both donor and acceptor sites of the Agdsx. No splice-relevant SNPs were identified in the female-specific intron 4 acceptor site and the corresponding region in males. Two SNPs (rs48712947, rs48712962) were found in the female-specific donor site of exon 5. They were not specific to either males or females as the rs48712947 was found in female mosquitoes from Cameroon, and in both males and females from Burkina Faso. In the other splice sites, the intron 3 acceptor site carried the greatest abundance of SNPs. Conclusions: There were no gender association between the identified SNPs and the random distribution of these SNPs in mosquito populations. The SNPs in Agdsx splice sites are not critical for the alternative splicing. Other molecular mechanisms should be considered and investigated.
La debida diligencia del inversionista extranjero. Un concepto bidimensional
Authors: Rivas-Ramírez Daniel 
Published: January 2022

Una de las características propias del derecho internacional de las inversiones es la forma en la que, a partir de su lenguaje, su estructura y su funcionamiento, está pensado para ofrecer mayores herramientas para los inversionistas extranjeros. De allí que en realidad, las relaciones que de él se derivan sean asimétricas, beneficiando en buena medida a los particulares y dejando con pocas herramientas a los Estados; en particular, en el marco de los arbitrajes internacionales de inversión. Ahora bien, un concepto que ha sido utilizado en algunas oportunidades y que ha servido como herramienta para la defensa de los Estados es el de la debida diligencia de los inversionistas. No obstante, se trata de una noción disímil y en buena medida indeterminada. Este artículo propone, a partir de un estudio teórico, doctrinario y “jurisprudencial”, definir la debida diligencia –de los inversionistas- como un concepto híbrido multinivel del que se derivan obligaciones claras y exigibles para los inversionistas respecto de sí mismos, los Estados receptores y los individuos a los que afectan con sus inversiones.