bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic analysis of digestive tract peptidases and lipases from the invasive gastropod Pomacea canaliculata
Authors: Escobar‐Correas Sophia , Mendoza‐Porras Omar , Castro‐Vazquez Alfredo , Vega Israel A. , Colgrave Michelle L. 
Published: December 2022

AbstractBackgroundThe invasive gastropod Pomacea canaliculata has received great attention in the last decades as a result of its negative impact on crops agriculture, yet knowledge of their digestive physiology remains incomplete, particularly the enzymatic breakdown of macromolecules such as proteins and lipids.ResultsDiscovery proteomics revealed aspartic peptidases, cysteine peptidases, serine peptidases, metallopeptidases and threonine peptidases, as well as acid and neutral lipases and phospholipases along the digestive tract of P. canaliculata. Peptides specific to peptidases (139) and lipases (14) were quantified by targeted mass spectrometry. Digestion begins in the mouth via diverse salivary peptidases (nine serine peptidases; seven cysteine peptidases, one aspartic peptidase and 22 metallopeptidases) and then continues in the oesophagus (crop) via three luminal metallopeptidases (Family M12) and six serine peptidases (Family S1). Downstream, the digestive gland provides a battery of enzymes composed of aspartic peptidase (one), cysteine peptidases (nine), serine peptidases (12) and metallopeptidases (24), including aminopeptidases, carboxypeptidases and dipeptidases). The coiled gut has M1 metallopeptidases that complete the digestion of small peptides. Lipid extracellular digestion is completed by triglyceride lipases.ConclusionFrom an integrative physiological and anatomical perspective, P. canaliculata shows an unexpected abundance and diversity of peptidases, which participate mainly in extracellular digestion. Moreover, the previously unknown occurrence of luminal lipases from the digestive gland is reported for the first time. Salivary and digestive glands were the main tissues involved in the synthesis and secretion of these enzymes, but plausibly the few luminally exclusive peptidases are secreted by ventrolateral pouches or epithelial unicellular glands. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Decomposition of VOCs by a novel catalytic DBD plasma reactor: A pilot study
Authors: Zhao Yafei , Zhuang Ye , Ye Kai , Wu Yifei , Luo Changhe , Li Dan , Zhang Yi , Yao Jin , Ali Sajid 
Published: December 2022

AbstractA pilot‐scale multi‐tube dielectric barrier discharge (DBD) reactor coupled with a series of Mn−Ag based catalysts for VOCs abatement was set up and investigated. The DBD with 2 %Ag‐MnOx/Al2O3 catalyst exhibited the best performance of removal efficiency (85.4 %) and energy yield (5.2 g/kWh) of toluene at the specific energy density of 39.7 J/L, much higher than the single DBD reactor (34.9 %, 2.1 g/kWh). Moreover, the degradation efficiencies of styrene, dimethyl, ethyl acetate and xylene in the plasma catalysis system were also studied. The catalyst presented high stability during the 50 hours of toluene plasma‐catalysis oxidation. Finally, the physicochemical properties of this catalyst were characterized and discussed using an energy dispersive spectrometer, X‐ray diffraction patterns, and X‐ray photoelectron spectroscopy.
Highly‐Dispersed Vanadium Nitride Supported on Porous Nitrogen‐Doped Carbon Material as a High‐Performance Cathode for Lithium‐Sulfur Batteries
Authors: Wang Li , Sun Chaoyang , Ji Shan , Linkov Vladimir , Wang Hui 
Published: December 2022

AbstractTransition metals and their compounds supported on carbon materials are widely used as cathodes for lithium‐sulfur batteries. Vanadium nitride is considered to be a promising cathode because of its good adsorption capacity for lithium polysulfides and high catalytic activity, but in practice it usually shows insufficient electrical conductivity and low electrocatalytic activity due to particles agglomeration. In this study, highly dispersed vanadium nitride supported on porous nitrogen‐doped carbon was prepared via one‐pot pyrolysis in a molten salt medium. Physical characterization revealed VN particles with a uniform size distribution of ca. 10 nm well dispersed on the carbon surface. When used as a cathode for Li−S battery, the material delivered a specific discharge capacity of 1050 mAh g−1 at 0.2 C and good rate performance. During the stability test over 500 continuous cycles, the average decay rate was 0.059 % per cycle. The study demonstrates prospective application of the newly developed electrocatalytic material as a cathode in lithium‐sulfur batteries.
High Dispersion FeFe2O4 nanoparticles synthesis and its Oxygen Reduction Reaction catalytic performance
Authors: Guo Likui , Zhang Junjie , Sun Yin , Liu Sen , Liu Wei , Dong Wenjing , Huang Naibao , Sun Xiannian 
Published: December 2022

AbstractBy pyrolyzed the products from hydrothermal reaction of 1, 4, 5, 8‐naphthalene tetramethyl anhydride, NaOH and FeSO4, the nanoparticles of FeFe2O4 were produced, and then its electrochemical performance of oxygen reduction reaction (ORR) was evaluated in O2 saturated 0.1 M KOH solution. The results indicated that, among all the as‐prepared samples, FeFe2O4‐0.50 was mainly composed of uniformly dispersed spherical nanoparticles of 20‐30nm and behaved the best ORR catalytic performance. Its half‐wave potential and limiting diffusion current density was 0.61 V and −1.85 mA cm−2@0.4 V vs. RHE), respectively, higher about 20 mV and 1.29 mA cm−2 than that of FeFe2O4 (0.59 V and −0.56 mA cm−2@0.4 V vs. RHE). In addition, FeFe2O4‐0.50 also showed stronger stability as well as methanol/CO tolerance than that of commercial 20 % Pt/C. It was the evenly dispersed FeFe2O4 nanoscale and Fe−O bond in FeFe2O4‐0.50 that contributed its excellent electrochemical performance and tolerance for CO and methanol. The as‐prepare FeFe2O4‐0.50 might be a potential alternative catalyst for ORR in fuel cell.
Application of the Quetiapine Templated Molecular Imprinted Polymer in Its Extraction from Human Blood Plasma; an Experimental and Density Functional Theory Study
Authors: Alikahi Naghmeh , Daraei Bahram , Torkian Leila , Shekarchi Maryam 
Published: December 2022

AbstractIn the present project, we have applied a molecular imprinted polymer (MIP) for the solid phase extraction (SPE) of quetiapine residue from human blood plasma. This study aimed to develop a method for determination of the bioavailability of quetiapine as a widely used antipsychotic in the blood serum. The extraction of quetiapine from the plasma was optimized and the loading amount (LA) for its adsorption was determined. Subsequently, a HPLC‐UV/VIS method was validated and applied to analyze the concentration of the mentioned drug which was extracted from the blood serum. The results showed that the limit of detection (LOD), and the limit of quantification (LOQ) for the validated MIP‐SPE approach were about 0.0172 ng ml−1, and 0.0481 ng ml−1, respectively. Finally, each of the MIP, and the non‐imprinted polymer (NIP), and their complex with the guest drug were designed and optimized by the density functional theory (DFT) approach. Based on our theoretical calculations, the structural properties, as well as the reactivity parameters (the molecular descriptors) were extracted, and debated. The results of the theoretical calculations showed a good agreement with the experimental results. Those results confirmed the favorability of adsorption of the drug by MIP compared to NIP.
Silica Nanoparticles Trigger Chaperone HSPB8‐Assisted Selective Autophagy via TFEB Activation in Hepatocytes
Authors: Zhu Ye , Zhang Yukang , Fan Zhuying , Fang Yuting , Zheng Yucao , Li Yang , Yang Man , Guo Caixia , Li Yanbo , Zhou Xianqing , Sun Zhiwei , Wang Ji 
Published: December 2022

AbstractSilica nanoparticles (SiNPs) are one of the most common inorganic nanomaterials. Autophagy is the predominant biological response to nanoparticles and transcription factor EB (TFEB) is a master regulator of the autophagy–lysosome pathway. Previous studies show that SiNPs induce autophagosome accumulation, yet the precise underlying mechanisms remain uncertain. The present study investigates the role of TFEB during SiNP‐induced autophagy. SiNP‐induced TFEB nuclear translocation is verified using immunofluorescence and western blot assay. The regulation of TFEB is proved to be via EIF2AK3 pathway. A TFEB knockout (KO) cell line is constructed to validate the TFEB involvement in SiNP‐induced autophagy. The transcriptomes of wild‐type and TFEB KO cells are compared using RNA‐sequencing to identify genes of the TFEB‐mediated autophagy and lysosome pathways affected by SiNPs. Based on these data and the Human Autophagy Database, four candidate autophagic genes are identified, including HSPB8, ATG4D, CTSB and CTSD. Specifically, that the chaperone HSPB8 is upregulated through SiNP‐mediated TFEB activation and forms a chaperone‐assisted selective autophagy (CASA) complex with BAG3 and HSC70, triggering HSPB8‐assisted selective autophagy, is found. Thus, this study characterizes a novel mechanism underlying SiNP‐induced autophagy that helps pave the way for further research on the toxicity and risk assessment of SiNPs.
Plasmonic Cyclic Au Nanosphere Hexamers
Authors: Kim Jeongwon , Lee Sungwoo , Son Jiwoong , Kim Jieun , Hilal Hajir , Park Minsun , Jung Insub , Nam Jwa‐Min , Park Sungho 
Published: December 2022

AbstractRational design of plasmonic colloidal assemblies via bottom‐up synthesis is challenging but would show unprecedented optical properties that strongly relate to the assembly's shape and spatial arrangement. Herein, the synthesis of plasmonic cyclic Au nanosphere hexamers (PCHs) is reported, wherein six Au nanospheres (Au NSs) are connected via thin metal ligaments. By tuning Au reduction, six dangling Au NSs are interconnected with a core hexagon nanoplate (NPL). Then, Pt atoms are selectively deposited on the edges of the spheres. After etching of the core, necklace‐like nanostructures of Pt framework are obtained. Deposition of Au is followed, leading to PCHs in high yield (≈90%). Notably, PCHs exhibit the combinatorial plasmonic characteristics of individual Au NSs and the in‐plane coupling of the six linked Au NSs. They yield highly uniform, reproducible, and polarization‐independent single‐particle surface‐enhanced Raman scattering signals, which are attributed to the 2‐dimensional isotropic alignment of the Au NSs. Those are applied to a SERS‐based immunoassay as quantitative and qualitative single particle SERS nanoprobes. This assay shows a low limit‐of‐detection, down to 100 pm, which is orders of magnitude lower than those based on Au NSs, and one order of magnitude lower than an assay using analogous particles of smooth Au nanorings.
Resiliente und robuste KI-Systeme im praktischen Einsatz
Authors: Wittenbrink Nicole , Demirci Stefanie , Wischmann Steffen 
Published: December 2022

ZusammenfassungDie vielfältigen neuen Möglichkeiten Künstlicher Intelligenz (KI) faszinieren in Wirtschaft und Gesellschaft gleichermaßen – von der Produktion bis hin zu Bereichen, die von lebensverändernden und risikoreichen Entscheidungen geprägt sind, wie dem Gesundheitswesen oder auch dem autonomen Fahren. Mit dem praktischen Einsatz steigen die Anforderungen an KI-Systeme im Hinblick auf ihre Robustheit und Resilienz.
Lieferkettenresilienz: Krisenfest oder effizient?
Authors: Schmidt Anne , Wolf Stefan , Kerbusch Jochen 
Published: December 2022

ZusammenfassungGlobale Lieferketten sind sensibel und vulnerabel. Jederzeit. Das haben die Erfahrungen während der COVID-19-Pandemie 2020 noch einmal deutlich vor Augen geführt. Rein auf Effizienz ausgerichtete Lieferketten bieten weder Sicherheit noch die notwendige Flexibilität, um zeitnah und angemessen auf Störungen reagieren zu können. Auch hat sich gezeigt, dass branchenübergreifende Gesamtlösungen aufgrund unterschiedlicher Lieferkettenstrukturen keine Option sind. Wie aber lassen sich Lieferketten resilient gestalten? Mit einem Wort: Weitsicht ist das A und O.
Multiscale modeling of the mechanical behavior of brazed Ni-based superalloy sheet metals
Authors: Huber Jakob , Vogler Jonas , Werner Ewald 
Published: December 2022

AbstractThe elastic–plastic behavior of brazed Ni-based superalloys used in abradable turbomachinery sealing systems is analyzed by means of numerical simulations. A sequential multiscale modeling approach is employed to analyze the relevant effects on the mechanical behavior of a layered composite consisting of the braze metal and the joining partners. The focus of the investigations lies on the role of the multiphase microstructure within the brazing layer and the significance of microscopic parameters such as, for example, the volume fraction of the phases compared to macroscopic parameters (e.g., the brazing layer thickness). A representative volume element is employed on the microscale, and a layered composite is modeled on the macroscale to capture all relevant effects on both length scales during mechanical loading of the layered material composite. Virtual tensile tests at different temperatures and strain rates are chosen as a controlled testing environment that captures the characteristic loading conditions during a rubbing event in a turbomachinery. The parameter on the microscale with the highest influence on the mechanical behavior is the volume ratio of the brittle and ductile phases. It also has a significant effect on the macroscopic mechanical behavior. To reduce the risk of damage, it is advised to minimize the fraction of brittle phases in the brazing layer. According to the simulation results, this can be even more effective than reducing the overall thickness of the brazing layer. Additionally, an improvement of an existing analytical model for the estimation of the flow stress in the ductile phase of a dual-phase microstructure is proposed. By increasing the order of the root function in the analytic model, the effect of stress distribution between brittle and ductile phases can be incorporated in an empirical manner. This reduces the deviation between the analytical and the numerical approaches significantly.
Vertical deformation and residual altimeter systematic errors around continental Australia inferred from a Kalman-based approach
Authors: Rezvani Mohammad-Hadi , Watson Christopher S. , King Matt A. 
Published: December 2022

AbstractWe further developed a space–time Kalman approach to investigate time-fixed and time-variable signals in vertical land motion (VLM) and residual altimeter systematic errors around the Australian coast, through combining multi-mission absolute sea-level (ASL), relative sea-level from tide gauges (TGs) and Global Positioning System (GPS) height time series. Our results confirmed coastal subsidence in broad agreement with GPS velocities and unexplained by glacial isostatic adjustment alone. VLM determined at individual TGs differs from spatially interpolated GPS velocities by up to ~ 1.5 mm/year, yielding a ~ 40% reduction in RMSE of geographic ASL variability at TGs around Australia. Our mission-specific altimeter error estimates are small but significant (typically within ~  ± 0.5–1.0 mm/year), with negligible effect on the average ASL rate. Our circum-Australia ASL rate is higher than previous results, suggesting an acceleration in the ~ 27-year time series. Analysis of the time-variability of altimeter errors confirmed stability for most missions except for Jason-2 with an anomaly reaching ~ 2.8 mm/year in the first ~ 3.5 years of operation, supported by analysis from the Bass Strait altimeter validation facility. Data predominantly from the reference missions and located well off narrow shelf regions was shown to bias results by as much as ~ 0.5 mm/year and highlights that residual oceanographic signals remain a fundamental limitation. Incorporating non-reference-mission measurements well on the shelf helped to mitigate this effect. Comparing stacked nonlinear VLM estimates and altimeter systematic errors with the El Niño-Southern Oscillation shows weak correlation and suggests our approach improves the ability to explore nonlinear localized signals and is suitable for other regional- and global-scale studies.
Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
Authors: Mohamed Magda F. , Ibrahim Nada S. , Saddiq Amna A. , Almaghrabi Omar A. , Al-Hazemi Maha E. , Hassaneen Hamdi M. , Abdelhamid Ismail A. 
Published: December 2022

AbstractA new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line.
Real Forms of Complex Lie Superalgebras and Supergroups
Authors: Fioresi Rita , Gavarini Fabio 
Published: December 2022

AbstractWe investigate the notion of real form of complex Lie superalgebras and supergroups, both in the standard and graded version. Our functorial approach allows most naturally to go from the superalgebra to the supergroup and retrieve the real forms as fixed points, as in the ordinary setting. We also introduce a more general notion of compact real form for Lie superalgebras and supergroups, and we prove some existence results for Lie superalgebras that are simple contragredient and their associated connected simply connected supergroups.
Lymphatic malformations in children: retrospective review of surgical and interventional management
Authors: Poget Marion , Fresa Marco , El Ezzi Oumama , Saliou Guillaume , Doan Marie-Thérèse , de Buys Roessingh Anthony 
Published: December 2022

Abstract
Purpose
Lymphatic malformations (LMs) are classified as macrocystic, microcystic or mixed. Treatment depends on their characteristics: surgery, sclerotherapy, both combined, systemic treatment or observation. This study aims to analyze the surgical and interventional management of LMs in children over the last two decades in our university hospital.

Methods
Management of children born with LMs between 2000 and 2019 was reviewed. Parameters collected were: malformation characteristics, type of treatment, symptoms, imaging, timing of diagnosis and first treatment, number of interventions, recovery rate, complications and length of stay.

Results
Files of 48 children were reviewed: 27 with macrocystic and 21 with microcystic LMs. There was no statistically significant difference in type of treatment except for combined treatment, more performed in microcystic LMs (p = 0.04). Symptoms, imaging, timing of diagnosis and first treatment, number of interventions and complications were not statistically significant. Overall, the number of surgeries was lower than sclerotherapies (p = 0.04). Recovery rate after surgery was higher in macrocystic LMs (p = 0.01). Complications and length of stay were not statistically significant.

Conclusion
A good rate of recovery was observed when surgery was performed, with no significant increase in complications and length of stay. A prospective study will be determinant to create a decisional algorithm for children with LMs.
Exceptional response to neoadjuvant targeted therapy with the selective RET inhibitor selpercatinib in RET-fusion-associated sarcoma
Authors: Schrenk Karin G. , Weschenfelder Wolfram , Spiegel Christian , Agaimy Abbas , Stöhr Robert , Hartmann Arndt , Gaßler Nikolaus , Drescher Robert , Freesmeyer Martin , Malouhi Amer , Bürckenmeyer Florian , Aschenbach René , Teichgräber Ulf , Kögler Christine , Vogt Matthias , Hofmann Gunther O. , Hochhaus Andreas 
Published: December 2022

AbstractWith the increasing use of next-generation sequencing, highly effective targeted therapies have been emerging as treatment options for several cancer types. Recurrent gene-fusions have been recognized in sarcomas; however, options for targeted therapy remain scarce. Here, we describe a case of a sarcoma, associated with a RET::TRIM33-fusion gene with an exceptional response to a neoadjuvant therapy with the selective RET inhibitor selpercatinib. Resected tumor revealed subtotal histopathologic response. This is the first report of successful targeted therapy with selpercatinib in RET-fusion-associated sarcomas. As new targeted therapies are under development, similar treatment options may become available for sarcoma patients.
Electrodeposition of nickel–iron on stainless steel as an efficient electrocatalyst coating for the oxygen evolution reaction in alkaline conditions
Authors: Wang Yifu , Williamson Nigel , Dawson Richard , Bimbo Nuno 
Published: December 2022

AbstractSignificant amount of effort has been devoted in the development of water electrolysis technology as the prime technology for green hydrogen production. In this paper, we investigate nickel–iron-based electrocatalytic coatings on stainless-steel substrates for commercial alkaline water electrolysers. Stainless steel electrodes for water electrolysis have received attention lately, showing that they can be a low-cost substrate for water electrolysis. Coating stainless steel with low-cost electrocatalysts can prove beneficial to lower overpotential for the oxygen evolution reaction (OER), thereby reducing the overall energy consumption of water electrolysis at an affordable cost. We show that NiFe-deposited substrates have an overpotential of 514 mV at 10 mA cm−2 current. The substrates also exhibited excellent stability in strong alkaline condition for 60 h under continuous 1.2 V working potential vs SCE. The results in full-cell electrolysers demonstrate that the electrolyser with the NiFe-coated anode could generate nearly six times as much current density compared with the bare stainless-steel substrate.
Graphical abstract
Cyclophosphamide treatment modifies the thermal stability of profilin bound monomeric and leiomodin2 bound filamentous actin
Authors: Szatmári Dávid , Bugyi Beáta , Pintér Réka , Lőrinczy Dénes 
Published: December 2022

AbstractThe monomeric (G-actin) and polymer (F-actin) forms of actin play important role in muscle development and contraction, cellular motility, division, and transport processes. Leiomodins 1–3 (Lmod1–3) are crucial for the development of muscle sarcomeres. Unlike tropomodulins that localize only at the pointed ends, the striated muscle specific Lmod2 shows diffuse distribution along the entire length of the thin filaments. The G-actin-binding profilin (Pro) facilitates the nucleotide exchange on monomeric actin and inhibits the polymerization at the barbed end, therefore contributes to the maintenance of the intracellular pool of polymerization competent ATP-G-actin. Cyclophosphamide (CP) is a cytostatic drug that can have potential side effects on muscle thin filaments at the level of actin in myofilaments. Here, we aimed at investigating the influence of CP on actin and its complexes with actin-binding proteins by using differential scanning calorimetry (DSC). We found that upon CP treatment, the denaturation of the Pro-G-actin and Lmod2-F-actin complexes was characterized by an increased enthalpy change. However, after the CP treatment, the melting temperature of F-actin was the same as in the presence of Lmod2, seems like Lmod2 does not have any effect on the structure of the CP alkylated F-actin. In case of Pro bound G-actin the melting temperature did not respond to the CP addition. The intracellular function of Lmod2 in muscle cells can be modified within CP drug treatment.