bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Adolescent Mental Health into HIV Prevention and Treatment Programs: Can Implementation Science Pave the Path Forward?
Authors: Boshe Judith , Brtek Veronica , Beima-Sofie Kristin , Braitstein Paula , Brooks Merrian , Denison Julie , Donenberg Geri , Kemigisha Elizabeth , Memiah Peter , Njuguna Irene , Poku Ohemaa , Roberts Sarah T. , Shayo Aisa M. , Dow Dorothy E. 
Published: November 2022

AbstractAdolescent mental health (AMH) is a critical driver of HIV outcomes, but is often overlooked in HIV research and programming. The implementation science Exploration, Preparation, Implementation, Sustainment (EPIS) framework informed development of a questionnaire that was sent to a global alliance of adolescent HIV researchers, providers, and implementors working in sub-Saharan Africa with the aim to (1) describe current AMH outcomes incorporated into HIV research within the alliance; (2) identify determinants (barriers/gaps) of integrating AMH into HIV research and care; and (3) describe current AMH screening and referral systems in adolescent HIV programs in sub-Saharan Africa. Respondents reported on fourteen named studies that included AMH outcomes in HIV research. Barriers to AMH integration in HIV research and care programs were explored with suggested implementation science strategies to achieve the goal of integrated and sustained mental health services within adolescent HIV programs.
External validity of multi-criteria preference data obtained from non-random sampling: measuring cohesiveness within and between groups
Authors: Babashahi Saeideh , Hansen Paul , Peeters Ronald 
Published: November 2022

AbstractAn important component of multi-criteria decision analysis (MCDA) in the public sector is the elicitation and aggregation of preference data collected via surveys into the relative importance of the criteria for the decision at hand. These aggregated preference data, usually in the form of mean weights on the criteria, are intended to represent the preferences of the relevant population overall. However, random sampling is often not feasible for public-sector MCDA for logistical reasons, including the expense involved in identifying and recruiting participants. Instead, non-random sampling methods such as convenience, purposive or snowball sampling are widely used. Nonetheless, provided the preference data collected are sufficiently ‘cohesive’ in terms of the extent to which the weights of the individuals belonging to the various exogenously defined groups in the sample are similar, non-random sampling can still produce externally valid aggregate preference data. We explain a method for measuring cohesiveness using the Kemeny and Hellinger distance measures, which involve measuring the ‘distance’ of participants’ weights (and the corresponding rankings of the criteria) from each other, within and between the groups respectively. As an illustration, these distance measures are applied to data from a MCDA to rank non-communicable diseases according to their overall burden to society. We conclude that the method is useful for evaluating the external validity of preference data obtained from non-random sampling.
Analysis of barriers, supports and gender gap in the choice of STEM studies in secondary education
Authors: Merayo Noemí , Ayuso Alba 
Published: November 2022

AbstractSociety is more digitised than ever and there is an urgent need to train people in these sectors, where women are still under-represented. A quantitative descriptive, correlational and explanatory descriptive design was used to identify barriers, supports and gender gaps in Science, Technology, Engineering and Mathematics in Secondary Education by analysing the interest and perception of 1562 students and 432 teachers. Descriptive statistics, Chi-square and Lambda test and Crame’s V or Phi test were performed together with a qualitative analysis. The results show that fewer female students want to pursue STEM studies, with girls preferring health and education professions and boys preferring engineering and computer science. Indeed, their motivation is different since we found correlations between being a girl and choosing STEM for helping people and society, while earning money is important for boys. Girls believe more necessary than boys to have qualities to study STEM and less often perceive themselves as intelligent and courageous. Our study revealed that families and teachers encourage more boys than girls towards STEM activities. Teachers believe that girls are influence by preconceived ideas, lack of STEM knowledge and lower self-esteem. Regarding gender equality, almost half state that no objectives are included in the curricula, 43.85% do not include it in subjects and only 30% received training. Consequently, female vocations need to be promoted by teaching how STEM solves real-life problems, fostering creativity, increasing self-confidence, promoting STEM activities and making female role models visible. Teachers should receive more gender training and promote gender-sensitive STEM education.
Re-Consenting Pediatric Research Participants as Legal Adulthood Approaches: Lessons from the SPARK Autism Study
Authors: Anderson Connie , Iampieri Alan , Franklin Leah , Daniels Amy , Diehl Katharine , Law J. Kiely 
Published: November 2022

AbstractTo explore issues surrounding re-consenting youth in longitudinal studies as they reach legal adulthood interviews were conducted with 46 parents plus 13 autistic teens enrolled in the Simons Foundation Powering Autism Research for Knowledge (SPARK) study. Qualitative analysis focused on family sensitivities regarding guardianship decisions, transition concerns, and the re-consenting process. Questions regarding guardianship were difficult for parents unsure of a teen’s future status. Mothers were key facilitators of re-consenting for soon-to-be-independent teens. As legal adulthood approached, parents were willing to assist teens with re-consenting but needed support, asking for multiple contacts, transition resources, and explanatory materials from the research team. Most teens were not cognizant of SPARK but willing to continue participation once made aware.
Postmarketing all-case surveillance trends and contribution to safety measures of drugs approved in Japan: a cross-sectional survey in 1999–2019
Authors: Nakao Minami , Nakamura Yuri , Shimokawa Masafumi , Maeda Hideki 
Published: November 2022

Abstract
Background
Postmarketing all-case surveillance (PACS) is a safety monitoring activity predominantly conducted for drugs with few domestic clinical trials, orphan drugs, or anticancer drugs that potentially cause serious adverse events.

Aim
This study comprehensively analyzed drugs in Japan requiring PACS as an approval condition and those implementing PACS-results-based safety measures.

Method
We included drugs approved in Japan between 1999 and 2019.

Results
During the 20-year survey, 1871 drugs were approved in Japan, including 277 (14.8%) requiring PACS as an approval prerequisite. The drug number requiring PACS for approval and its ratio to the total approved-drug number is increasing annually. In 2018, the number and percentage of PACS-requiring drugs reached a 37-drug maximum (32.5%). Additionally, among the 277 PACS-requiring drugs, upon examining the results of 87 drugs for which reexamination results had already been obtained, all 87 drugs (31.4%) were found to be in Category 1 which means there is no need to revise drug-approval conditions, indicating that their usefulness is consistent with approval. Furthermore, measures such as revising the package insert and providing information to medical institutions were adopted for 53 drugs, 14 of which had PACS-results-based safety measures.

Conclusion
PACS implementation for drug approval will potentially continue increasing. Normally, PACS is not conducted overseas, as it is a safety-monitoring activity exclusive to Japan, and the burden on institutions, such as medical sites and pharmaceutical companies, is heavy. Thus, ensuring a balance between the obtained effect and this burden is imperative.
A heuristic approach based on Leiden rankings to identify outliers: evidence from Italian universities in the European landscape
Authors: Daraio Cinzia , Di Leo Simone , Leydesdorff Loet 
Published: November 2022

AbstractWe propose an innovative use of the Leiden Rankings (LR) in institutional management. Although LR only consider research output of major universities reported in Web of Science (WOS) and share the limitations of other existing rankings, we show that they can be used as a base of a heuristic approach to identify “outlying” institutions that perform significantly below or above expectations. Our approach is a non-rigorous intuitive method (“heuristic”) because is affected by all the biases due to the technical choices and incompleteness that affect the LR but offers the possibility to discover interesting findings to be systematically verified later. We propose to use LR as a departure base on which to apply statistical analysis and network mapping to identify “outlier” institutions to be analyzed in detail as case studies. Outliers can inform and guide science policies about alternative options. Analyzing the publications of the Politecnico di Bari in more detail, we observe that “small teams” led by young and promising scholars can push the performance of a university up to the top of the LR. As argued by Moed (Applied evaluative informetrics. Springer International Publishing, Berlin, 2017a), supporting “emerging teams”, can provide an alternative to research support policies, adopted to encourage virtuous behaviours and best practices in research. The results obtained by this heuristic approach need further verification and systematic analysis but may stimulate further studies and insights on the topics of university rankings policy, institutional management, dynamics of teams, good research practice and alternative funding methods.
Laughing Matters: Humor, Free Speech and Hate Speech at the European Court of Human Rights
Authors: Godioli Alberto , Young Jennifer , Fiori Brando Matteo 
Published: November 2022

AbstractThis article conducts an interdisciplinary analysis of a corpus consisting of ten cases from the European Court of Human Rights. The selected cases range from 2004 to 2022 and engage with the nexus between hate speech and humorous expression, spanning across various forms of humor (from political satire to disaster jokes) and different media (from verbal jokes to cartoons). Building on insights from linguistics, semiotics and literary theory, we discuss how the ECtHR deals with the interpretive challenges posed by humor, with particular attention to the following key aspects: (1) The rhetorical/semiotic mechanisms underlying the contested verbal, visual or multimodal texts; (2) The dialogue between the contested expression and previous texts by means of allusion, commentary or parody; (3) The role played by a broad range of contextual factors, including the conventions of a given humorous genre as well as the specific socio-political circumstances in which humor is produced and circulated; (4) The possible outcomes of the interpretive process, namely the different manners in which humor and disparagement may relate to each other in a given disputed expression; (5) The ways in which courts can reconstruct the actual or presumed reception of an ambiguous joke or cartoon within a given audience. In addition to highlighting a number of recurring issues and occasional inconsistencies in the corpus, this contribution aims to demonstrate how humanities-based humor research can set the basis for a more consistent and methodical approach to humor in court, with special but not exclusive regard to hate speech jurisprudence.
The concentration of potentially toxic elements (PTEs) in drinking water from Shiraz, Iran: a health risk assessment of samples
Authors: Mohammadpour Amin , Emadi‬ Zahra , Samaei Mohammad Reza , Ravindra Khaiwal , Hosseini Seyedeh Masoumeh , Amin Mohammad , Samiei Mojtaba , Mohammadi Leili , Khaksefidi Razyeh , Zarei Amin allah , Motamed-Jahromi Mohadeseh , Mousavi Khaneghah Amin 
Published: November 2022

AbstractThe existence of potentially toxic elements (PTEs) in water bodies has posed a menace to human health. Thus, water resources should be protected from PTEs, and their effect on the exposed population should be investigated. In the present investigation, the concentrations of PTEs such as lead (Pb), mercury (Hg), manganese (Mn), and iron(Fe) in the drinking water of Shiraz, Iran, were determined for the first time. In addition, hazard quotient, hazard index, cancer risk, and sensitivity analysis were applied to estimate the noncarcinogenic and carcinogenic impacts of Pb, Hg, Mn, and Fe on exposed children and adults through ingestion. The mean concentrations (µg/L) of Pb, Hg, Mn, and Fe were 0.36, 0.32, 2.28, and 8.72, respectively, in winter and 0.50, 0.20, 0.55, and 10.36, respectively, in summer. The results displayed that Fe concentration was more than the other PTEs. PTE concentrations were lower than the standard values of the Environment Protection Agency and World Health Organization. Values of the degree of contamination and heavy metal pollution index for lead, mercury, manganese, and iron were significantly low (< 1) and excellent (< 50), respectively. Based on the Spearman rank correlation analysis, positive and negative relationships were observed in the present study. The observations of the health risk assessment demonstrated that mercury, lead, iron, and manganese had an acceptable level of noncarcinogenic harmful health risk in exposed children and adults (hazard quotients < 1 and hazard index < 1). The carcinogenic risk of lead was low (< E − 06), which can be neglected. Monte Carlo simulation showed that water intake rate and mercury concentration were the most critical parameters in the hazard index for children and adults. Lead concentration was also the most crucial factor in the cancer risk analysis. The results of the present study proved that the drinking water of Shiraz is safe and healthy and can be confidently consumed by people.
Obsessive-compulsive symptoms and resting-state functional characteristics in pre-adolescent children from the general population
Authors: Weeland Cees J. , van den Heuvel Odile A. , White T. , Tiemeier H. , Vriend C. 
Published: November 2022

AbstractWhile functional brain characteristics of obsessive-compulsive disorder have been extensively studied, literature on network topology and subnetwork connectivity related to obsessive-compulsive symptoms (OCS) is sparse. Here we investigated the functional brain characteristics of OCS in children from the general population using a multiscale approach. Since we previously observed OCS-related differences in thalamus morphology, we also focused on the network participation of thalamic subregions. The study included 1701 participants (9–12 years) from the population-based Generation R study. OCS were measured using the Short Obsessive-Compulsive Disorder Screener. We studied the brain network at multiple scales: global network topology, subnetwork connectivity and network participation of thalamic nodes (pre-registration:https://osf.io/azr9c). Modularity, small-worldness and average participation coefficient were calculated on the global scale. We used a data-driven consensus community approach to extract a partition of five subnetworks involving thalamic subregions and calculate the within- and between-subnetwork functional connectivity and topology. Multiple linear regression models were fitted to model the relationship between OCS and functional brain measures. No significant associations were found when using our preregistered definition of probable OCS. However, post-hoc analyses showed that children endorsing at least one OCS (compared with controls) had higher modularity, lower connectivity between frontoparietal, limbic and visual networks as well as altered participation of the lateral prefrontal thalamus node. Our results suggest that network characteristics of OCS in children from the general population are partly symptom-specific and severity-dependent. Thorough assessment of symptom dimensions can deepen our understanding of OCS-related brain networks.
Transferability of robotic console skills by early robotic surgeons: a multi-platform crossover trial of simulation training
Authors: Larkins Kirsten M. , Mohan Helen M. , Gray Matthew , Costello Daniel M. , Costello Anthony J. , Heriot Alexander G. , Warrier Satish K. 
Published: November 2022

AbstractRobotic surgical training is undergoing a period of transition now that new robotic operating platforms are entering clinical practice. As this occurs, training will need to be adapted to include strategies to train across various consoles. These new consoles differ in multiple ways, with some new vendors using flat screen open source 3D enhanced vision with glasses and differences in design will require surgeons to learn new skills. This process has parallels with aviation credentialling across different aircraft described as type rating. This study was designed to test the hypothesis that technical robotic console operating skills are transferrable across different robotic operating platforms. Ten participants sequentially completed four Mimic®(Surgical Science) simulation exercises on two different robotic operating platforms (DaVinci®, Intuitive Surgical and HUGO™ RAS, Medtronic). Ethical approval and informed consent were obtained for this study. Groups were balanced for key demographics including previous robotic simulator experience. Data for simulation metrics and time to proficiency were collected for each attempt at the simulated exercise and analysed. Qualitative feedback on multi-platform learning was sought via unstructured interviews and a questionnaire. Participants were divided into two groups of 5. Group 1 completed the simulation exercises on console A first then repeated these exercises on console B. Group 2 completed the simulated exercises on console B first then repeated these exercises on console A. Group 1 candidates adapted quicker to the second console and Group 2 candidates reached proficiency faster on the first console. Participants were slower on the second attempt of the final exercise regardless of their allocated group. Quality and efficiency metrics and risk and safety metrics were equivalent across consoles. The data from this investigation suggests that console operating skills are transferrable across different platforms. Overall risk and safety metrics are within acceptable limits regardless of the order of progression of console indicating that training can safely occur across multiple consoles contemporaneously. This data has implications for the design of training and certification as new platforms progress to market and supports a proficiency-based approach.
Low temperature, cold spells, and cardiorespiratory hospital admissions in Helsinki, Finland
Authors: Sohail Hasan , Kollanus Virpi , Tiittanen Pekka , Mikkonen Santtu , Lipponen Anne H. , Zhang Siqi , Breitner Susanne , Schneider Alexandra , Lanki Timo 
Published: November 2022

Abstract

There is only limited scientific evidence with varying results on the association between hospital admissions and low ambient temperatures. Furthermore, there has been no research in Northern Europe on cold-associated morbidity. Therefore, this study investigated the associations of daily wintertime temperature and cold spells with cardiorespiratory hospital admissions in the Helsinki metropolitan area, Finland. Daily number of non-elective hospital admissions for 2001–2017 was obtained from the national hospital discharge register and meteorological data from the Finnish Meteorological Institute. Quasi-Poisson regression models were fitted, controlling for potential confounders such as time trend, weekday, holidays, air pollution, barometric pressure, and influenza. The associations of cold season daily mean ambient temperature and cold spells with hospital admissions were estimated using a penalized distributed lag linear models with 21 lag days. Decreased wintertime ambient temperature was associated with an increased risk of hospitalization for myocardial infarction in the whole population (relative risk [RR] per 1 °C decrease in temperature: 1.017, 95% confidence interval [CI]: 1.002–1.032). An increased risk of hospital admission for respiratory diseases (RR: 1.012, 95% CI: 1.002, 1.022) and chronic obstructive pulmonary disease (RR: 1.031, 95% CI: 1.006, 1.056) was observed only in the ≥ 75 years age group. There was an independent effect of cold spell days only for asthma admissions (RR: 2.348, 95% CI: 1.026, 5.372) in the all-ages group. Cold temperature increases the need for acute hospital care due to myocardial infarction and respiratory causes during winter in a northern climate.
Erratum to: Cold Atmosphere Plasma Modification on Beta-Carotene-Loaded Nanofibers to Enhance Osteogenic Differentiation
Authors: Moradi Yasamin , Atyabi Seyed Alireza , Ghiassadin Ali , Bakhshi Hadi , Irani Shiva , Atyabi Seyed Mohammad , Dadgar Neda 
Published: November 2022

The article Cold Atmosphere Plasma Modification on Beta-Carotene-Loaded Nanofibers to Enhance Osteogenic Differentiation, written by Yasamin Moradi, Seyed Alireza Atyabi, Ali Ghiassadin, Hadi Bakhshi, Shiva Irani, Seyed Mohammad Atyabi, and Neda Dadgar, was mistakenly originally published without open access. After publication in Vol.23, No.1, page 18–27 this was corrected and the article was made an open access publication. Therefore, the copyright of the article has been changed to and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (https://doi.org/10.1007/s12221-021-0033-y), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The original article has been corrected.
Early Postnatal Exposure to Intermittent Hypercapnic Hypoxia (IHH), but Not Nicotine, Decreases Reelin in the Young Piglet Hippocampus
Authors: Despotovski Vanessa , Vivekanandarajah Arunnjah , Waters Karen A. , Machaalani Rita 
Published: November 2022

AbstractThis study evaluated the expression of reelin, an extracellular protein involved in lamination and migration of neurons, in the hippocampus of young piglets, and quantified to examine the following: (i) baseline levels within layers of the hippocampus and dentate gyrus (DG); (ii) differences between ventral and dorsal hippocampi; and (iii) changes attributable to postnatal exposure to continuous nicotine for 12 days, or intermittent hypercapnic hypoxia (IHH), with further analysis according to duration of IHH (1 vs 4 days). Additionally, we analysed whether any exposure altered DG morphology and whether it is related to altered reelin expression. Reelin was visualised via immunohistochemistry, and the number of positive reelin cells/mm2 was measured in the CA4/Hilus, layers of the DG, and the CA1. The dorsal DG had significantly more reelin within the subgranular zone compared to the ventral DG (p < 0.01). There was no difference in reelin between nicotine (n = 5) and controls (n = 5). IHH exposed piglets (n = 10) had significantly lowered reelin in the CA1 (p = 0.05), specifically the stratum pyramidale (p = 0.04) and the hippocampal fissure (p = 0.02), compared to their controls (n = 7); the duration of IHH had no effect. No exposure was associated with an alteration in DG morphology. This study shows that postnatal IHH exposure decreased reelin expression in the developing piglet hippocampal CA1, suggesting that IHH may result in altered neuronal migration.