bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quando o Atlântico encontra o Mediterrâneo: o fantástico em O céu não sabe dançar sozinho, de Ondjaki
Authors: Fraccari Sabrina Ferraz , Paz Demétrio Alves 
Published: July 2022

O objetivo deste artigo é reconhecer, nos contos “Budapeste”, “Madrid” e “Giurgiu”, de O céu não sabe dançar sozinho (2014), de Ondjaki, a presença de elementos característicos do fantástico que nos ajudem a perceber outras nuances da obra do autor. Utilizamos as contribuições teóricas de Mata (2000), Cardoso (2008), Todorov (1999), Furtado (1980) e Ceserani (2006). A ambiguidade e a figura do narrador-personagem são centrais nas narrativas fantásticas porque elas conduzem o leitor, demonstrando os caminhos que este deve seguir. O narrador-personagem encontra-se muitas vezes ameaçado e presencia fatos insólitos, os quais não busca explicar, mantendo sempre a dúvida acerca daquilo que narra.
Interatrial Block Predicts Life‐Threatening Arrhythmias in Dilated Cardiomyopathy
Authors: Henkens Michiel T. H. M. , López Martínez Helena , Weerts Jerremy , Sammani Arjan , Raafs Anne G. , Verdonschot Job A. J. , van de Leur Rutger R. , Sikking Maurits A. , Stroeks Sophia , van Empel Vanessa P. M. , Brunner‐La Rocca Hans‐Peter , van Stipdonk Antonius M. W. , Farmakis Dimitrios , Hazebroek Mark R. , Vernooy Kevin , Bayés‐de‐Luna Antoni , Asselbergs Folkert W. , Bayés‐Genís Antoni , Heymans Stephane R. B. 
Published: July 2022

Background
Interatrial block (IAB) has been associated with supraventricular arrhythmias and stroke, and even with sudden cardiac death in the general population. Whether IAB is associated with life‐threatening arrhythmias (LTA) and sudden cardiac death in dilated cardiomyopathy (DCM) remains unknown. This study aimed to determine the association between IAB and LTA in ambulant patients with DCM.

Methods and Results

A derivation cohort (Maastricht Dilated Cardiomyopathy Registry; N=469) and an external validation cohort (Utrecht Cardiomyopathy Cohort; N=321) were used for this study. The presence of IAB (P‐wave duration>120 milliseconds) or atrial fibrillation (AF) was determined using digital calipers by physicians blinded to the study data. In the derivation cohort, IAB and AF were present in 291 (62%) and 70 (15%) patients with DCM, respectively. LTA (defined as sudden cardiac death, justified shock from implantable cardioverter‐defibrillator or anti‐tachypacing, or hemodynamic unstable ventricular fibrillation/tachycardia) occurred in 49 patients (3 with no IAB, 35 with IAB, and 11 patients with AF, respectively; median follow‐up, 4.4 years [2.1; 7.4]). The LTA‐free survival distribution significantly differed between IAB or AF versus no IAB (both
P
<0.01), but not between IAB versus AF (
P
=0.999). This association remained statistically significant in the multivariable model (IAB: HR, 4.8 (1.4–16.1),
P
=0.013; AF: HR, 6.4 (1.7–24.0),
P
=0.007). In the external validation cohort, the survival distribution was also significantly worse for IAB or AF versus no IAB (
P
=0.037;
P
=0.005), but not for IAB versus AF (
P
=0.836).

Conclusions
IAB is an easy to assess, widely applicable marker associated with LTA in DCM. IAB and AF seem to confer similar risk of LTA. Further research on IAB in DCM, and on the management of IAB in DCM is warranted.
RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease
Authors: Shimizu Chisato , Kim Jihoon , He Ming , Tremoulet Adriana H. , Hoffman Hal M. , Shyy John Y‐J. , Burns Jane C. 
Published: July 2022

Background
Damage to the coronary arteries during the acute phase of Kawasaki disease (KD) is linked to inflammatory cell infiltration, myointimal proliferation, and endothelial cell (EC) dysfunction. To understand the response of ECs to KD treatment, we studied the genome‐wide transcriptional changes in cultured ECs incubated with KD sera before and after treatment with or without atorvastatin.

Methods and Results

RNA sequencing of human umbilical vein ECs incubated with pooled sera from patients with acute KD before or after treatment with intravenous immunoglobulin and infliximab revealed differentially expressed genes in interleukin‐1, tumor necrosis factor‐α, and inflammatory cell recruitment pathways. Subacute sera pooled from patients treated with intravenous immunoglobulin, infliximab, and atorvastatin uniquely induced expression of
NOS3
, Kruppel like factor (
KLF2
, and
KLF4
(promotes EC homeostasis and angiogenesis) and ZFP36 ring finger protein (ZFP36) and suppressor of cytokine signaling 3 (SOCS3) (suppresses inflammation), and suppressed expression of
TGFB2
and
DKK1
(induces endothelial‐mesenchymal transition) and sphingosine kinase 1 (SPHK1) and C‐X‐C motif chemokine ligand 8 (CXCL8) (induces inflammation).

Conclusions
These results suggest that atorvastatin treatment of patients with acute KD may improve EC health, reduce mediators of inflammation produced by ECs, and block KD‐induced myofibroblast proliferation.
Arctic and Pacific Ocean Conditions Were Favorable for Cold Extremes over Eurasia and North America during Winter 2020/21
Authors: Zhang Ruonan , Screen James A. , Zhang Renhe 
Published: July 2022

Abstract
A sequence of extreme cold events occurred across Eurasia and North America during winter 2020/21. Here, we explore the causes and associated mechanisms for the extremely cold temperatures using both observations and large-ensemble simulations. Experiments were conducted with observed ocean surface boundary conditions prescribed globally, and regionally to discern the specific influence of Arctic, tropical Pacific, and North Pacific drivers. Increased likelihood of daily cold extremes in mid-December to mid-January are found in Eurasian midlatitudes in response to reduced Arctic sea ice. Tropical sea surface temperature anomalies, more specifically the La Niña pattern, increased probability of extreme cold over high-latitude Eurasia in early January to early February. Both reduced Arctic sea ice and La Niña increased the probability of daily cold extremes over western North America in late January to late February. We conclude that a combination of reduced Arctic sea ice, La Niña, and a sudden stratospheric warming in January 2021 were factors in the February 2021 extreme cold wave that caused huge societal disruptions in Texas and the southern Great Plains. Although the magnitude of the simulated cold extremes are relatively small when compared with observed anomalies, the Arctic and Pacific Ocean surface conditions in winter 2020/21 increased the probability of cold days as cold or colder than observed by approximately 17%–43%.
Spatiotemporal Heterogeneity in Precipitation over China and Its Connections with Large-Scale Climate Oscillations—A Moisture Budget Perspective
Authors: Lu Chen , Huang Guohe , Wang Xiuquan , Wang Feng 
Published: July 2022

Abstract
Climate change can lead to variations in the probability distribution of precipitation. In this study, quantile regression (QR) is undertaken to identify the quantile trends in precipitation over China and to examine the quantile effects of various climate oscillations on precipitation. The results show that the quantile trends show apparent seasonal variations, with a greater number of stations showing trends in winter (especially at quantile levels ≥ 0.5), and larger average magnitudes of trends at nearly all quantile levels in summer. The effects of El Niño–Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), and Pacific decadal oscillation (PDO) exhibit evident variations with respect to the quantile level. Spatial clusters are subsequently identified based on the quantile trends, and the individual and combined effects from the teleconnection patterns are further investigated from the perspective of moisture budget. Seven spatial clusters with distinct seasonal quantile trends can be identified; three of them are located in southeastern China and are characterized by increasing trends in summer and winter precipitation. Summer precipitation over this region is positively influenced by ENSO and negatively influenced by NAO, with the former affecting both the dynamic and thermodynamic components of vertically integrated moisture divergence and the latter affecting only the dynamic component. The interaction effect of ENSO and NAO on summer precipitation anomalies in months that are extremely wetter than normal is statistically significant. In comparison, winter precipitation in this region is under the positive influence of ENSO and NAO and the negative influence of PDO; the effect of ENSO on moisture convergence can be mainly attributed to its dynamic component.
Chagas disease in children from the Gran Chaco region: A bibliographic appraisal
Authors: Mendicino Diego , Bottasso Oscar 
Published: July 2022

In the Gran Chaco region, the Pan American Health Organization (PAHO) declared the interruption of vector transmission of Chagas Disease in Paraguay and some district of Argentina. After a bibliographic search, by using the words “Chagas, prevalence, children, Chaco”, on scientiphic articles indexed in Pubmed and Lilacs during the 2010–2021 period, we found nine studies which dealt with entomological data seroprevalence surveys of Chagas Disease in Argentine children and three studies in Bolivian children. More field studies need to be published to better understand the epidemiological situation in children from the region. Due to its social and ecological characteristics, the Gran Chaco region remains a hotspot for Chagas Disease affecting disproportionally rural communities and certain vulnerable ethnics groups.
HDL-C levels added to the MELD score improves 30-day mortality prediction in Asian patients with cirrhosis
Authors: Wang Yue , Shen Wenjuan , Huang Fang , Yu Chenyan , Xi Liting , Gao Jingwen , Yin Minyue , Liu Xiaolin , Lin Jiaxi , Liu Lu , Zhang Huixian , Zhu Jinzhou , Hong Yu 
Published: July 2022

Objectives Lower high-density lipoprotein cholesterol (HDL-C) levels have been observed in chronic liver disease patients. The aim of this study was to develop a model that incorporates HDL-C levels and the Model for End-stage Liver Disease (MELD) score to predict 30-day mortality in Asian cirrhosis patients. Methods Cirrhosis patients were recruited from two hospitals in this retrospective observational study. Propensity score matching was used. The model’s performance was evaluated, including its ability to predict 30-day mortality, accuracy, and clinical utility. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were calculated. Results The HDL-C + MELD model showed good ability to predict 30-day mortality (area under the curve, 0.784; sensitivity, 0.797; specificity, 0.632), which was better than that of the MELD score alone. It also showed good calibration and a net benefit for all patients, which was better than that of the MELD score, except at the threshold probability. NRI and IDI results confirmed that adding HDL-C levels to the MELD score improved the model’s performance in predicting 30-day mortality. Conclusion We added HDL-C levels to the MELD score to predict 30-day mortality in Asian patients with cirrhosis. The HDLC + MELD model shows good ability to predict 30-day mortality and clinical utility.
Radiographic Assessment of Ankle Fracture Displacement: A Validation Study
Authors: Gitajn I. Leah , Natoli Roman M. , Spitler Clay A. , Firoozabadi Reza , Tatman Lauren M. , Gary Joshua L. , Githens Michael F. , Thompson Richard E. , DeLuca Andrea , Reider Lisa , Wysocki Elizabeth , Obremskey William 
Published: July 2022

Background: Ankle fracture displacement is an important outcome in clinical research examining the effectiveness of surgical and rehabilitation interventions. However, the assessment of displacement remains subjective without well-described or validated measurement methods. The aim of this study was to assess inter- and intrarater reliability of ankle fracture displacement radiographic measures and select measurement thresholds that differentiate displaced and acceptably reduced fractures. Methods: Eight fellowship-trained orthopaedic surgeons evaluated a set of 26 postoperative ankle fracture radiographs on 2 occasions. Surgeons followed standardized instructions for making 5 measurements: coronal displacement (3) talar tilt (1), and sagittal displacement (1). Inter- and intraobserver interclass correlations were determined by random effects regression models. Logistic regression was used to determine the optimal sensitivity and specificity for the measurements with the highest correlation. Results: Three of the 5 measures had excellent interobserver reliability (correlation coefficient > 0.75): (1) coronal plane distance between the lateral border of tibia and lateral border of talus, (2) coronal plane talar tilt, and (3) sagittal plane displacement. The threshold that best discriminated displaced from well-aligned fractures was 2 mm for coronal plane distance (sensitivity 82.1%, specificity 85.4%), 3 degrees for talar tilt (sensitivity 80.4%, specificity 82.2%), and 5 mm for sagittal plane distance (sensitivity 83.9%, specificity 84.9%). Conclusion: This study identified 3 reliable measures of ankle fracture displacement and determined optimal thresholds for discriminating between displaced and acceptably reduced fractures. These measurement criteria can be used for the design and conduct of clinical research studying the impact of surgical treatment and rehabilitation interventions.
Reducing Suicidal Ideation in Preadolescents With a History of Foster Care by Promoting School Readiness in Early Childhood
Authors: Pears Katherine C. , Tiberio Stacey S. , Kim Hyoun K. 
Published: July 2022

Preadolescents with a history of foster care placement report suicidal ideation (SI) at higher rates than their peers, which increases their risk for suicide attempts in adolescence. Despite these increased risks, few interventions have been shown to reduce SI in these youth. This study examined the main and mediated long-term effects of a program to increase school readiness in children in foster care at age 5 years on SI when the children were ages 9–11 years, 4–6 years after the intervention ended. Children who received the intervention were less likely to report SI, although the difference did not reach statistical significance. The intervention reduced SI indirectly through its positive effect on children’s self-esteem at age 9 years. Implications for programming to reduce SI and subsequent suicide attempts in youth with a history of foster care are discussed.
Anti-cancer medicine shortages in an oncology tertiary hospital of Pakistan: A five-year retrospective study
Authors: Shukar Sundus , Yang Caijun , Khan Shahbaz Ahmad , Bhutta Omar Akhlaq 
Published: July 2022

Objective Anti-cancer medicine shortages are advancing challenges for patients and hospitals. This study aims to evaluate anti-cancer and supportive medicine shortages in a tertiary hospital in Pakistan and propose solutions. Method A retrospective observational research was performed in a tertiary care hospital in Pakistan from 2016 to 2020. Data was retrieved from the hospital database using a questionnaire regarding short medicines’ generic name, brand, dosage, source, total source, frequency, causes, impact, management, and analyzed by Microsoft Excel 2013. Results Between January 2016 and December 2020, 43 individual medicine shortages were observed, with an average of 8.6 shortages per year. There were shortages of 22 medicines, including 8 anti-cancer (36.4%) and 14 supportive agents (63.6%). Total shortage days were 27,100, with an average of 1232 days (SD 757) per medicine. Supportive medicines’ shortages were frequent, but oncology agents’ shortages were constant. The most affected dosage form was injection. Cardiovascular drugs and alkylating agents were the most affected class in supportive and anti-cancer medicines, respectively. The use of “alternative medicine” and “patient needs based importation” were the most common mitigation strategies. Conclusion Shortages of oncology medicines are challenging in Pakistan. The most prominent causes are the lack of updated governmental regulations, registration, and import issues. The tertiary care hospital has very few sources of supply, so it imports these drugs on a need basis to manage the shortages. But it is still concerning because of the huge financial burden on patients and institutions due to expensive import, and therapy become delayed as the import process takes time. Moreover, the most affected drug class was alkylating agents, and dosage was both injectable and oral medicines.
Identifying characteristics of non-completers in fear conditioning paradigms with children and adolescents
Authors: Flasinski Tabea , Sommer Katharina , Schneider Silvia , Margraf Jürgen , Pflug Verena , Lippert Michael W , Christiansen Hanna , Cwik Jan C , Hamm Alfons O , In-Albon Tina , Knappe Susanne , Pauli Paul , Richter Jan , Tuschen-Caffier Brunna , Adolph Dirk 
Published: July 2022

The number of studies on fear conditioning in children and adolescents has increased in recent years. Most of these studies exclusively focus on data of completers while dropout rates, reasons for dropout, and specific characteristics of non-completers are underreported. This study systematically investigated data of 283 children and adolescents between 8 and 17 years ( M = 11.10 , SD = 2.14) undergoing a differential fear conditioning paradigm using a female scream as unconditioned stimulus (US). The sample included 230 children and adolescents with a current primary anxiety disorder (separation anxiety disorder, social anxiety disorder, and specific phobia) and 53 non-anxious controls. The dropout rate was 24.1%. The most common reason to discontinue was being afraid of the US (59.1%) followed by the startle probe being too loud (15.2%). Logistic regressions revealed that younger age and a present anxiety disorder predicted dropout. There seem to be distinct characteristics potentially predicting dropout from fear conditioning paradigms. Thus, interpretability and generalizability of those paradigms are limited when non-completers are not considered. Future research should conscientiously look at these data more closely and investigate paradigms that work independent of age and diagnostic status.
Participant perspectives of automated short messaging service interventions to promote physical activity: A systematic review and thematic synthesis
Authors: Grobler J Stefanus , Stavric Verna , Saywell Nicola L 
Published: July 2022

Introduction Short messaging service has the potential to improve participation in physical activity in individuals with long-term health conditions. However, successful implementation relies on participant engagement with such programmes. The aim of this study was to undertake a systematic review of qualitative literature exploring participant perspectives of short messaging service-based interventions designed to promote physical activity for people with long-term health conditions. Methods CINHAL, MEDLINE, SPORTSDiscus, Scopus and Web of Science were searched up to 15 February 2021 looking for participants’ perspectives on short messaging service programmes designed to promote physical activity in people with long-term health conditions. Included studies were analysed using thematic synthesis. Results Eight studies involving 533 participants were included and analysed using the principles of thematic analysis and 10 descriptive themes were identified. These descriptive themes were further refined to develop five final analytical themes: taking control of my own health, from information to action, relationship with the programme, perfection required for success and increased expectations. Discussion The findings agree with published work on the factors which influence behaviour. The findings from this synthesis demonstrate that automated short messaging service programmes to increase physical activity are generally acceptable. People report that these interventions support and encourage physical activity. The novel finding of this study was that having more regular and long-lasting contact has the potential to increase the expectations people have of healthcare services. This is a finding which needs to be considered and managed but should not discourage the use of automated short messaging service.
Health Professionals’ Opinions About Secondary Prevention of Diabetes-Related Foot Disease
Authors: Drovandi Aaron , Seng Leonard , Crowley Benjamin , Fernando Malindu E. , Evans Rebecca , Golledge Jonathan 
Published: July 2022

Purpose: The purpose of this study was to explore the perceptions of health professionals regarding the ideal design of a remotely delivered diabetes-related foot disease (DFD) secondary prevention program. Methods: A qualitative study involving 33 semistructured phone interviews was conducted with health professionals with experience managing DFD. Interviews discussed the role of health professionals in managing DFD, their experience in using telehealth, perceived management priorities, preferences for a secondary prevention management program, and perceived barriers and facilitators for such a program. Interviews were audio-recorded and transcribed, and inductive thematic analysis was used to derive key themes. Results: Three themes were derived: (1) barriers in current model of DFD care, (2) facilitators and ideas for a remotely delivered secondary prevention program, and (3) potential challenges in implementation. DFD care remains acute-care focused, with variability in access to care and a lack of “clinical ownership.” Patients were perceived as often having poor knowledge and competing priorities, meaning engagement in self-care remains poor. Participants felt a remote secondary prevention program should be simple to follow and individualized to patients’ context, with embedded support from a case manager and local multidisciplinary service providers. Challenges to implementation included limited DFD awareness, poor patient motivation, patient-related issues with accessing and using technology, and the inability to accurately assess and treat the foot over telehealth. Conclusions: Health professionals felt that an ideal remotely delivered secondary prevention program should be tailored to patients’ needs with embedded support from a case manager and complemented with multidisciplinary collaboration with local service providers.