bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrevista com André Guyaux
Authors: Schellino Andrea , Cervoni Aurélia , Veras Eduardo , Abes Gilles Jean , Pessoa Nícollas Ranieri de Moraes 
Published: September 2022

André Guyaux é professor emérito da Faculdade de Letras da Sorbonne Université. Autor de um livro sobre a “fortuna crítica” de Baudelaire (Baudelaire. Un demi-siècle de lectures des « Fleurs du Mal », 1855-1905, PUPS, 2007), publicou Fusées e Mon coeur mis à nu na coleção Folio (2016). Ele codirige a revista anual de estudos baudelairianos, L’Année Baudelaire. Também editou as Œuvres complètes (2009) de Rimbaud na Bibliothèque de la Pléiade e codirigiu a edição de Romans et nouvelles (2019) de Huysmans na mesma coleção.
Sulforaphane Enhances the Anticancer Properties of Paclitaxel in Two Human Derived Prostate Cancer Cell Lines
Authors: Habib Tito Naeem , Altonsy Mohamed Omar , Ghanem Salah Abdelmoneim , Salama Mohammed Said , Hosny Mai Abd El Hafieth 
Published: September 2022

Abstract
Background: In cancer therapy, combined treatment results in additive and synergistic outcomes and reduces the development of drug resistance in response to anticancer agents compared with monotherapy. We propose that when Paclitaxel (Taxol, PTX) is combined with Sulforaphane (SFN), may result in better treatment outcomes in prostate cancer. Understanding the mechanism of drug synergy, as opposed to simply knowing which drugs to combine, enables further optimization of advantageous drug interactions and can provide efficient therapeutic strategies in preclinical research. Methods: We measured apoptosis, cell cycle, and expression of Bax and Bcl2 in response to the PTX and SFN individual and combined treatments. Cell lines (PC-3) and (LNCaP), were individually treated with different concentrations of PTX, SFN, and its combination. Annexin V/PI positivity and data analysis were conducted using a flow cytometer and guava data acquisition and analysis software. Graph-Pad Prism 6, and Microsoft Excel software were used for statistical analyses and graphs generation. Student’s t-tests or one-way analysis of variance with Tukey’s correction were used to determine the significant difference between mono- and combination treatments.Results: The effect of the PTX or SFN treatments on reducing cell viability increased in a dose-dependent manner. Combined treatment enhanced PTX’s effects and reduced the EC50 values of both drugs compared to individual treatments. Flow cytometry analysis revealed that PTX or SFN treatments redistributed cell-cycle phases by inducing S-phase arrest and increasing apoptotic cell population in PC-3 cells. Such effects were enhanced in the PTX+SFN combination group. Interestingly, the necrotic cells were not affected by the combination treatments. Caspase-3 cleavage and morphological deformations of the cell nuclei are signs of apoptotic cell death; such parameters were examined by western blot and fluorescent microscopy in response to mono- and combination treatments.Conclusion: The PTX or SFN differentially modulated the expression of Bax and Bcl2 in PC-3 and LNCaP cell lines, and the combined treatment enhanced these effects in favor of cell apoptosis versus survival. Our data indicated that combination therapy of PTX and SFN significantly increased Bax protein expression and Bax: Bcl2 ratio compared to PTX or SFN individual treatments. Such findings will help develop new biomarkers and guide therapy choices.
Poor air passenger knowledge of COVID-19 symptoms and behaviour undermines strategies aimed at preventing the import of SARS-CoV-2 into the UK
Authors: Jones David. L. , Rhymes Jennifer M. , Green Emma , Doyle Charlotte , Kevill Jessica L. , Malham Shelagh K. , Weightman Andrew J. , Farkas Kata 
Published: September 2022

Abstract
Background
Air travel mediates transboundary movement of SARS-CoV-2. To prepare for future pandemics, we sought to understand air passenger behaviour and perceived risk during the COVID-19 pandemic.
Methods
This study of UK adults (n = 2103) quantified knowledge of COVID-19 symptoms, perceived health risk of contracting COVID-19, likelihood of returning to the UK with COVID-19 symptoms, likelihood to obey self-quarantining guidelines, how safe air travellers felt when flying during the pandemic (n = 305), and perceptions towards face covering effectiveness.
Results
Overall knowledge of COVID-19 symptoms was poor. Men and younger age groups (18–44) were less informed than women and older age groups (44+). A significant proportion (21%) of the population would likely travel back to the UK whilst displaying COVID-19 symptoms with many expressing that they would not fully comply with self-isolation guidelines. Overall, males and younger age groups had a reduced perceived personal risk from contracting COVID-19, posing a higher risk of transporting SARS-CoV-2 back to the UK.
Conclusion
Poor passenger knowledge and behaviour undermines government guidelines and policies aimed at preventing SARS-CoV-2 entry into the UK. This supports the need for stricter, clearer and more targeted guidelines with point-of-departure viral testing and stricter quarantining upon arrival.
Health and Peacebuilding in Colombia: challenges and opportunities of a community training process for the post-accord
Authors: González-Uribe Catalina , Simbaqueba Melissa Arena , León-Giraldo Sebastián , Arias-Gómez Luis F. , Rodríguez David Alejandro , Hernández-Neuta Ginna Esmeralda , Moreno-Serra Rodrigo , Bernal Oscar 
Published: September 2022

Abstract
Following the peace agreement process in Colombia and to guarantee the right to health, a national educational program to train community leaders in technical education in public health was designed and implemented. Using qualitative methodologies, we sought reflections about the impact of the training process on the 'participant's life projects, collecting information from previous and current experiences and expectations after the program. Participants (n = 44) included peasants, afro-Colombian and indigenous communities, displaced people, victims of the armed conflict, and ex-combatants of the Revolutionary Armed Forces of Colombia - Army of the People (FARC-EP). Data collection through ethnographic observation, focus groups, and individual semi-structured interviews took place between October and November 2018. Results indicate that the participants saw the program as an opportunity to meet their goals and have better opportunities for their lives; change their way of thinking, and be reflective and open to discussion. Historical governmental and institutional abandonment was identified as a barrier for trust in the program and uncertainty on its potential benefits. Daily life co-existence during the training was a challenge between participants given their diverse backgrounds in the context of conflict in Colombia. It is important to create friendly and explanatory strategies to generate trust with and among participants accompanied with psychological support, ease successful interaction, and generate wellbeing through the program's implementation.
AuthROS: Secure Data Sharing Among Robot Operating Systems Based on Ethereum
Authors: Zhang Shenhui , Tao Songjing , Li Xiulai , Wu Shuang , Tang Ming , Tang Zeping , Liang Zhixuan , Liu Bernie 
Published: September 2022

Abstract
The Robot Operating System (ROS) streamlines human processes, increasing the efficiency of various production tasks. However, the security of data transfer operations in ROS is still in its immaturity. Securing data exchange between several robots is a significant problem. This paper proposes \textit{AuthROS}, an Ethereum blockchain-based secure data sharing method, for robot communication. It is a ROS node authorization system capable of ensuring the immutability and security of private data flow between ROS nodes of any size. To ensure data security, AuthROS employs the smart contract for permission granting and identification, SM2-based key exchange, and SM4-based plaintext encryption techniques. In addition, we deploy a data digest upload technique to optimize data query and upload performance. Finally, the experimental findings reveal that AuthROS has strong security, time performance, and node forging in cases where data should be recorded and robots need to remain immobile.
Anterior Cingulate Glutamate Metabolites as a Predictor of Antipsychotic Response in First Episode Psychosis: data from the STRATA collaboration.
Authors: Egerton Alice , Griffiths Kira , Casetta Cecila , Deakin John , Drake Richard , Howes Oliver , Kassoumeri Laura , Khan Sobia , Lankshear Steve , Lees Jane , Lewis Shôn , Mikulskaya Elena , Millgate Edward , Oloyede Ebenezer , Pollard Rebecca , Rich Nathalie , Segev Aviv , Sendt Kyra-Verena , MacCabe James 
Published: September 2022

AbstractElevated brain glutamate has been implicated in non-response to antipsychotic medication in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from the first episode of psychosis (FEP) could allow stratification of patients; for example, patients predicted not to respond to standard antipsychotics could be fast-tracked to clozapine. Using proton magnetic resonance spectroscopy (1H-MRS), we examined the ability of glutamate and Glx (glutamate plus glutamine) in the anterior cingulate cortex (ACC) and caudate to predict response to antipsychotic treatment. A total of 89 minimally medicated patients with FEP not meeting symptomatic criteria for remission were recruited across two study sites.1H-MRS and clinical data were acquired at baseline, 2 and 6 weeks. Response was defined as >20% reduction in Positive and Negative Syndrome Scale (PANSS) Total score from baseline to 6 weeks. In the ACC, baseline glutamate and Glx were higher in Non-Responders and significantly predicted response (P < 0.02; n = 42). Overall accuracy was greatest for ACC Glx (69%) and increased to 75% when symptom severity at baseline was included in the model. Glutamate metabolites in the caudate were not associated with response, and there was no significant change in glutamate metabolites over time in either region. These results add to the evidence linking elevations in ACC glutamate metabolites to a poor antipsychotic response. They indicate that glutamate may have utility in predicting response during early treatment of first episode psychosis. Improvements in accuracy may be made by combining glutamate measures with other response biomarkers.
Herbivorous fish microbiome adaptations to sulfated dietary polysaccharides
Authors: Podell Sheila , Oliver Aaron , Kelly Linda Wegley , Sparagon Wesley , Nelson Robert S. , Laurens Lieve M. L. , Sims Neil A. , Nelson Craig E. , Allen Eric E. , Plominksy Alvaro M. , Augyte Simona 
Published: September 2022

Abstract
Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs. Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three different species of macro-algivorous Hawaiian kyphosids have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion. Assembled metagenomes from terrestrial ruminant microbiota containing carbohydrate-utilizing bacterial taxa closely related to those found in kyphosid fish, including Alistipes-related Bacteroidota and Clostridia-related Bacillota, were used as negative controls to identify shared features common to both marine and non-marine saccharolytic intestinal bacteria. This strategy provided the statistical power necessary to distinguish macro-algivorous digestion-specific activities from more generalized aspects of carbohydrate metabolism. Gene co-localization patterns of enriched digestive enzyme families on assembled contigs were used to identify polysaccharide utilization locus associations, and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides. These insights into the gut microbiota of herbivorous marine fish improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides, providing foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
Managing Postoperative Atrial Fibrillation After Open-Heart Surgery Using Transdermal β1 Blockers
Authors: Yamamoto Kenji , Miwa Senri , Yamada Tomoyuki , Setozaki Shuji , Hamuro Mamoru , Kurokawa Shunji , Enomoto Sakae 
Published: September 2022

Abstract
Objective: We aimed to describe the efficacy of a transdermal patch of bisoprolol for managing postoperative atrial fibrillation and flutter in thoracic surgical procedures.Methods: Among the 384 patients who underwent open-heart surgery at our hospital and received oral bisoprolol to prevent postoperative atrial fibrillation, 65 (16.9%) patients also received a 4-mg transdermal patch of bisoprolol for the control of heart rate of postoperative atrial fibrillation were analyzed. We applied the bisoprolol transdermal patch when the heart rate was >80 bpm and removed it at ≤60 bpm; an additional patch was applied when the heart rate was >140 bpm. Heparin calcium injections were administered twice daily for anticoagulation between 2 and 6 days postoperatively. Results: The average number of prescriptions for transdermal patches of bisoprolol during hospitalization was 1.8±1.1 (1–5). The median first prescription date was on a postoperative day 2 (range: days 0–37). Sinus rhythm in 18 patients (27.7%) recovered within 24 h. Eight patients (12.3%) were switched to continuous landiolol infusion due to persistent tachycardia. In three patients, the transdermal patch was removed due to severe bradycardia. Fifteen patients experienced persistent atrial fibrillation and were treated with electrical cardioversion during hospitalization. We did not observe serious complications that could be directly attributed to bisoprolol transdermal patch use. Conclusion: Single-use bisoprolol transdermal patch may help control heart rate during the initial treatment of postoperative atrial fibrillation after open-heart surgery.
Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health
Authors: Han Haige , Randhawa Imtiaz A. S. , MacHugh David E. , McGivney Beatrice A. , Katz Lisa M. , Dugarjaviin Manglai , Hill Emmeline W. 
Published: September 2022

Abstract
Background: Thousands of years of natural and artificial selection since the domestication of the horse has shaped the distinctive genomes of Chinese Mongolian horse populations. Consequently, genomic signatures of selection can provide insights into the human-mediated selection history of specific traits and evolutionary adaptation to diverse environments. Here, we used genome-wide SNPs from five distinct Chinese Mongolian horse populations to identify genes within genomic regions under selection for traits specific to Wushen (gait), Abaga Black (black coat colour) and Baicha Iron Hoof (hoof quality) horse, as well as other global breeds to identify regional-specific signatures of selection.Results: We first validated the use of the composite selection signals approach by identifying the most significant selection peak for the Wushen horse in the region on ECA23 harbouring DMRT3, the major gene for gait. We detected selection signatures encompassing several genes in the Baicha Iron Hoof horse that represent good biological candidates for hoof health, including the CSPG4, PEAK1, EXPH5, WWP2 and HAS3 genes. In addition, an analysis of regional subgroups (Asian compared to European) identified a single locus on ECA3 containing the ZFPM1 gene that is a marker of selection for the major domestication event leading to the DOM2 horse clade.Conclusions: Genomic variation at these loci in the Baicha Iron Hoof may be leveraged in other horse populations to identify animals with superior hoof health or those at risk of hoof-related pathologies. The overlap between the selection signature in Asian horses with the DOM2 selection peak raises questions about the nature of horse domestication events, which may have involved a prehistoric clade other than DOM2 that has not yet been identified.
Sleep alteration in the van der Pol-type circadian pacemaker model driven by natural light and intermitent noise
Authors: Tayong Fred Legrand Tsafack , Yamapi René , Filatrella Giovanni 
Published: September 2022

Abstract
Sleep/wake cycles were once dictated by the solar day, but now humans are subjected to prolonged exposure to artificial light, resulting in altered daily sleep patterns. We investigate a van der Pol-type mathematical model for a circadian model, which incorporates a daylight and noise model, to capture the consequences of artificial light, which has become part of our daily lives. The results show that when the cycle is interpreted as a model for the sleep/awake alternation, the duration and sleep offset are influenced by light intensity, daylight duration and noise intensity. Increasing light intensity and duration can lead to a decrease in sleep duration beyond ∼ 30 mins. Thus, the cycle of the circadian oscillations can be influenced by a sudden change in longitude (jet lag) is much more influenced by the daily duration of light than by its intensity. Noise could cause a loss of sleep of more than 10%; in other words, artificial light could cause a decrease of more than 40 mins in sleep time, which could cause a malfunction of the human mechanism. Furthermore, simulations show that the duration of sleep during the different seasons of the year reveals that it is in winter that sleep is longer in contrast to summer where the daily loss of sleep could be as much as 5% (∼ 20mins); nevertheless, the increase in noise intensity can decrease the duration of sleep in winter and make it shorter than in summer. The evolution of light over the year is slow enough for the oscillator to regulate sleep time, whereas a sudden change in latitude and the consequent change in daily light could cause major dysfunctions on sleep time and requires an adaptation time to be regulated; Indeed the adaptation to this change could take several cycles and depends on the environmental conditions, as it would be more difficult for the organism to regulate its sleep if moving from a point with long daylight to a position with shorter daylight than for a trip in the opposite direction. In brief, the mathematical van der Pol pacemaker model of the circadian rhythm driven by periodic and random terms, that mimic realistic illumination, provides quantitative information on alterations in the circadian sleep/wake pattern, in agreement with empirical observations.PACS numbers:
Carbon footprint of transhumant sheep farms: accounting for natural baseline emissions in Mediterranean systems
Authors: Pardo Guillermo , Casas Raquel , Prado Agustín del , Manzano Pablo 
Published: September 2022

Abstract
Purpose Transhumance has rarely been analyzed through LCA approaches, and there is little evidence about its emissions level when conducted under different practices (by truck or on hoof), or compared to static/sedentary livestock systems. Moreover, mobile pastoralism is strongly linked to natural resources by its seasonal grazing patterns, thereby occupying the niche of wild herbivores. Considering natural emission baselines in these ecosystems could have relevant effects when estimating their carbon footprint. Materials and methods Inventory data of 21 sheep farms was collected in order to estimate the carbon footprint (CF) of lamb meat produced. Farms were divided in 3 sub-groups representing typical management practices in the region: i) static (STAT), ii) transhumance by truck (THT) and iii) transhumance on hoof (THH). Livestock GHG emissions were modelled according to herd structure and IPCC guidelines. Off-farm emissions from external feeds and fuels were accounted based on existent LCA databases. A natural baseline of wild herbivores was established from the population of red deer reported in a hunting preserve, previously considered to be a reference for the natural carrying capacity in Mediterranean ecosystems. GHG emissions of wild herbivores were estimated through two methods based on: i) IPCC guidelines, and ii) allometric regression equations. Results and discussion Carbon footprint ranged from 16.4 up to 30.6 kgCO2eq per kg of lamb liveweight (LW). Significant differences were identified among static and transhumant farms, which consistently showed lower CF values (STAT: 26.3 kgCO2eq/kg LW, THT: 18.1 kg CO2eq/kg LW, THH: 18.1 kg CO2eq/kg LW). Static farms resulted in higher GHG emissions (+31%) and higher CO2 and N2O, contributions derived from the consumption of additional feeds. Both methods applied to compute emissions for wild herbivores led to similar results (25.3-26.8 Mg CO2eq/km2), comparatively lower than estimation for transhumant sheep (47.7 Mg CO2eq/km2). When considering natural baseline emissions, the CF of transhumant lamb meat is reduced by almost 30%, reaching values quite below those reported for intensive lamb production systems in Spain. Conclusions From our results, mobility of grazing livestock can be considered as a strategy promoting climate change mitigation. This is achieved mainly by reducing the need of external feeds, while maximizing the use of local forage resources that otherwise would be difficult to valorize. Further reductions in the CF result when considering natural baseline emissions. The application of this new GHG accounting perspective could have relevant implications when aiming at climate neutrality of grazing-based ruminant systems.
Conflict Resolution Styles and Skills and Variation among Medical Students
Authors: Gunasingha Rathnayaka M. K. D. , Lee Hui-Jie , Zhao Congwen , Clay Alison S. 
Published: September 2022

Abstract

Background: Conflict is inevitable on healthcare teams, yet few professional school curricula teach or assess conflict resolution skills. Little is known about the variation in conflict resolution styles across medical students and how these styles might impact conflict resolution skills.Methods: Graduating medical students completed a mandatory conflict resolution session with standardized patients acting as nurses during a transition to residency course. Coaches reviewed videotapes of simulated student-nurse encounters, focusing on students’ conflict resolution style (assessed with the Thomas-Kilman Instrument (TKI)) and student skills with negotiation and emotional intelligence. We also assessed the impact of knowing one’s conflict resolution style, student gender, race and intended field of practice on conflict resolution skills.Results: One hundred and eight students completed the simulated conflict session. Sixty-seven students completed the TKI before the simulated patient (SP) encounter and 41 after. The most common conflict resolution style was accommodating (n=40). Knowing one’s conflict resolution style in advance of the simulation and one’s identified race/ethnicity did not impact skill as assessed by faculty coaches. Students pursuing diagnosis-based specialties had higher negotiation (p=0.04) and emotional quotient (p=0.006) scores than those pursuing procedural specialties. Females had higher emotional quotient scores (p=0.02). Conclusions: Conflict resolution styles vary among medical students. Male gender and future practice in a procedural specialty impacted conflict resolution skills, but knowing conflict resolution style did not.