bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statement of the Italian Association of Medical Physics (AIFM) task group on radiation dose monitoring systems
Authors: Ria Francesco , D’Ercole Loredana , Origgi Daniela , Paruccini Nicoletta , Pierotti Luisa , Rampado Osvaldo , Rossetti Veronica , Strocchi Sabina , Torresin Alberto ,   Association of Medical Physics Task Group, Torresin Alberto , Pierotti Luisa , Belli Giacomo , Bregant Paola , Isoardi Paola , Mari Alberto , Nitrosi Andrea , Nocetti Luca , Paruccini Nicoletta , Quattrocchi Maria Grazia , Radice Anna , Rampado Osvaldo , Scrittori Nicoletta , Sottocornola Chiara , Strocchi Sabina , Sutto Marina , Zatelli Giovanna , Acchiappati Domenico , Aoja Rosa Antonella , Brambilla Marco , Branchini Marco , Cannatà Vittorio , Costi Tiziana , Cutaia Claudia , D.’Ercole Loredana , Del Vecchio Antonella , Delle Canne Stefania , Di Pasquale Maria , Elisabetta Silvia , Fabbri Cinzia , Faico Maria Daniela , Fantinato Daniele , Ghetti Caterina , Giannelli Marco , Giordano Carlo , Grisotto Simone , Guidi Gabriele , Lisciandro Francesco , Manco Luigi , Giorgio Marini Pier , Moresco Paola , Oberhofer Nadia , Origgi Daniela , Palleri Francesca , Pasquali Claudia , Pasquino Massimo , Peruzzo Andrea , Petrillo Giuseppe , Pini Silvia , Rembado Daniela , Ria Francesco , Riccardi Lucia , Rosasco Raffaella , Serelli Giulio , Soavi Raffaella , Stasi Michele , Taddeucci Adriana , Tonini Eugenia , Trianni Annalisa , Turano Piera , Venturi Giovanna , Zefiro Daniele , Zito Felicia 
Published: February 2022

AbstractThe evaluation of radiation burden in vivo is crucial in modern radiology as stated also in the European Directive 2013/59/Euratom—Basic Safety Standard. Although radiation dose monitoring can impact the justification and optimization of radiological procedure, as well as effective patient communication, standardization of radiation monitoring software is far to be achieved. Toward this goal, the Italian Association of Medical Physics (AIFM) published a report describing the state of the art and standard guidelines in radiation dose monitoring system quality assurance. This article reports the AIFM statement about radiation dose monitoring systems (RDMSs) summarizing the different critical points of the systems related to Medical Physicist Expert (MPE) activities before, during, and after their clinical implementation. In particular, the article describes the general aspects of radiation dose data management, radiation dose monitoring systems, data integrity, and data responsibilities. Furthermore, the acceptance tests that need to be implemented and the most relevant dosimetric data for each radiological modalities are reported under the MPE responsibility.
Additional evidence to support OCT-4 positive VSELs and EnSCs as the elusive tissue-resident stem/progenitor cells in adult mice uterus
Authors: Singh Pushpa , Metkari Siddhanath , Bhartiya Deepa 
Published: February 2022

AbstractObjectiveTrue identity and specific set of markers to enrich endometrial stem cells still remains elusive. Present study was undertaken to further substantiate that very small embryonic-like stem cells (VSELs) are the true and elusive stem cells in adult mice endometrium.MethodsThis was achieved by undertaking three sets of experiments. Firstly, SSEA-1+ andOct-4 + positive VSELs, sorted from GFP mice, were transplanted into the uterine horns of wild-type Swiss mice and GFP uptake was studied within the same estrus cycle. Secondly, uterine lumen was scratched surgically and OCT-4 expressing stem/progenitor cells were studied at the site of injury after 24–72 h. Thirdly, OCT-4  expression was studied in the endometrium and myometrium of adult mice after neonatal exposure to estradiol (20 µg/pup/day on days 5–7 after birth).ResultsGFP + ve VSELs expressing SSEA-1 andOct-4engrafted and differentiated into the epithelial cells lining the lumen as well as the glands during the estrus stage when maximum remodeling occurs. Mechanical scratching activated tissue-resident, nuclear OCT-4 positive VSELs and slightly bigger ‘progenitors’ endometrial stem cells (EnSCs, cytoplasmic OCT-4) which underwent clonal expansion and further differentiated into luminal and glandular epithelial cells. Neonatal exposure to endocrine disruption resulted in increased numbers of OCT-4 positive VSELs/EnSCs in adult endometrium.DiscussionResults support the presence of functionally active VSELs in adult endometrium. VSELs self-renew and give rise to EnSCs that further differentiate into epithelial cells under normal physiological conditions. Also, VSELs are vulnerable to endocrine insults. To conclude VSELs are true and elusive uterine stem cells that maintain life-long uterine homeostasis and their dysregulation may result in various pathologies.Graphical Abstract
Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values
Authors: Thornton Christina S. , Huntley Kevin , Berenger Byron M. , Bristow Michael , Evans David H. , Fonseca Kevin , Franko Angela , Gillrie Mark R. , Lin Yi-Chan , Povitz Marcus , Shafey Mona , Conly John M. , Tremblay Alain 
Published: February 2022

Abstract
Background
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is completed through reverse transcriptase-PCR (RT-PCR) from either oropharyngeal or nasopharyngeal swabs, critically important for diagnostics but also from an infection control lens. Recent studies have suggested that COVID-19 patients can demonstrate prolonged viral shedding with immunosuppression as a key risk factor.

Case presentation
We present a case of an immunocompromised patient with SARS-CoV-2 infection demonstrating prolonged infectious viral shedding for 189 days with virus cultivability and clinical relapse with an identical strain based on whole genome sequencing, requiring a multi-modal therapeutic approach. We correlated clinical parameters, PCR cycle thresholds and viral culture until eventual resolution.

Conclusions
We successfully demonstrate resolution of viral shedding, administration of COVID-19 vaccination and maintenance of viral clearance. This case highlights implications in the immunosuppressed patient towards infection prevention and control that should consider those with prolonged viral shedding and may require ancillary testing to fully elucidate viral activity. Furthermore, this case raises several stimulating questions around complex COVID-19 patients around the role of steroids, effect of antiviral therapies in absence of B-cells, role for vaccination and the requirement of a multi-modal approach to eventually have successful clearance of the virus.
PredicTF: prediction of bacterial transcription factors in complex microbial communities using deep learning
Authors: Oliveira Monteiro Lummy Maria , Saraiva João Pedro , Brizola Toscan Rodolfo , Stadler Peter F. , Silva-Rocha Rafael , Nunes da Rocha Ulisses 
Published: February 2022

Abstract
Background
Transcription factors (TFs) are proteins controlling the flow of genetic information by regulating cellular gene expression. A better understanding of TFs in a bacterial community context may open novel revenues for exploring gene regulation in ecosystems where bacteria play a key role. Here we describe PredicTF, a platform supporting the prediction and classification of novel bacterial TF in single species and complex microbial communities. PredicTF is based on a deep learning algorithm.

Results
To train PredicTF, we created a TF database (BacTFDB) by manually curating a total of 11,961 TF distributed in 99 TF families. Five model organisms were used to test the performance and the accuracy of PredicTF. PredicTF was able to identify 24–62% of the known TFs with an average precision of 88% in our five model organisms. We demonstrated PredicTF using pure cultures and a complex microbial community. In these demonstrations, we used (meta)genomes for TF prediction and (meta)transcriptomes for determining the expression of putative TFs.

Conclusion
PredicTF demonstrated high accuracy in predicting transcription factors in model organisms. We prepared the pipeline to be easily implemented in studies profiling TFs using (meta)genomes and (meta)transcriptomes. PredicTF is an open-source software available at https://github.com/mdsufz/PredicTF.
Researching arts, culture, migration and change: a multi (trans)disciplinary challenge for international migration studies
Authors: Martiniello Marco 
Published: February 2022

AbstractThe paper first discusses why it is important to research the relations between migration, arts, and cultures. Second, it discusses the most promising methodological options to do it fruitfully. It concludes by claiming that the additional value of such investigations is both to allow a more comprehensive understanding of the migration process, and to move away from the victimization of migrants “rehumanize” them.
A snapshot of consumer engagement in clinical trials in Australia: results of a national survey of clinical trial networks and research organisations
Authors: McKenzie Anne , Bowden Janelle , Zalcberg John R. , Conroy Karena , Fallon-Ferguson Julia , Jesudason Shilpanjali , Ansell James , Anderst Ania , Straiton Nicola 
Published: February 2022

Abstract
Background
Little is known about the extent, perceptions or experiences of consumers involved in clinical trials across Australia. The purpose of this National study was to better understand the activity and perceptions of clinical trial networks (CTNs), research co-ordinating centres and their consumers, around consumer involvement in clinical trials.

Methods
CTNs and research co-ordinating centres who were members of the Australian Clinical Trials Alliance (ACTA), and consumers involved in the activities of these organisations, were invited to participate in online surveys. Surveys were completed between April and September 2018.

Results
80 respondents completed the surveys in full: 25 of 34 CTNs, 5 from 15 research co-ordinating centres, and included research investigators of 13 active trials, 10 completed trials. There were 27 consumer respondents. Consumers were involved in clinical trial activities across 19/25 (76%) of CTNs and 3/5 (60%) of research co-ordinating centres. Consumers were involved at all stages of the trial cycle. Despite this, only 8/30 (27%) of research organisations provided specific training to their employees or members on consumer involvement in research, and most did not have a specific policy or process relating to conducting consumer involvement in clinical trials. At the organisation level, barriers to consumer involvement in clinical trials included being unsure how to involve consumers effectively and systematically, difficulty in accessing consumers or lack of infrastructure and resources. At the consumer level, barriers included limited understanding of their roles, a lack of resources and training. Enablers included education, training and funding for both the research sector and for consumers. Almost all consumer respondents (25/27; 92%) would recommend the consumer role to other potential consumers, stating it was a valuable experience that led to knowledge exchange and learning about the research process.

Conclusions
Over the last few years, consumer involvement in clinical trials has increased in Australia, but the scope of involvement varies across different research organisations, and therapeutic areas. Consumer involvement in clinical trials is valued by most that do it, however, there are opportunities to further foster and strengthen ongoing partnerships, for example by providing practical advice for researchers on how to best engage and involve consumers.
The role of motivation in MOOCs’ retention rates: a systematic literature review
Authors: Badali Mehdi , Hatami Javad , Banihashem Seyyed Kazem , Rahimi Ebrahim , Noroozi Omid , Eslami Zahra 
Published: February 2022

AbstractAlthough MOOCs platforms offer a unique way to provide information for a large cohort of participants, only a small percentage of participants complete MOOCs. The high number of dropouts in MOOCs is a key challenge, and the literature suggests that it can be affected by participants' motivation. However, it is not known how and to what extent motivation influences participants’ dropout in MOOCs. There is a need to provide an overview of the role of motivation in MOOCs’ retention. In this study, we aimed to identify motivational factors and theories that affect participants’ retention in MOOCs and explain how does motivation supports participants to complete MOOCs. To do so, a systematic review was conducted using specific inclusion and exclusion criteria and a set of relevant keywords and databases which resulted in 50 relevant publications. Our analysis led us to identify six main motivational factors that influence participants’ MOOCs completion including academic, social, course, personal, professional, and technological motives. These factors were divided into two main categories including need-based motivation and interest-based motivation. The results showed that academic motives play the most important role in participants’ MOOCs retention compared to the other factors. It was also found that self-determination theory was used as the most dominant theory to support participants’ motivation for MOOCs completion. In addition, the results revealed that the motivational factors not only impacts participants’ MOOCs retention directly, but also this impact is mediated by participant satisfaction, self-regulation, attitude toward using MOOCs, performance, engagement, and level of participation. Based on the results, further implications for practice and future research are provided.
To share or not to share: communication of caregiver-reported outcomes when a patient has colorectal cancer
Authors: Howard A. Fuchsia , Torrejón María-José , Lynch Kelsey , Beck Scott M. , Thorne Sally , Lambert Leah , Porcino Antony , De Vera Mary A. , Davies Janine M. , Avery Jonathan , Wolff Angela C. , McDonald Melanie , Lee Joyce W. K. , Hedges Penelope , Kelly Mary T. , McKenzie Michael 
Published: February 2022

Abstract
Background
The importance of patient-centered measurement in cancer care has led to recognition of the potential for caregiver-reported outcomes to improve caregiver, patient and healthcare system outcomes. Yet, there is limited evidence to inform caregiver-reported outcome implementation. Our purpose was to generate evidence to inform the meaningful and constructive integration of caregiver-reported outcomes into cancer care to benefit caregivers, including exploration of the question of the extent to which these assessments should be shared with patients. We focused on caregivers of patients with colorectal cancer (CRC) because CRC is common, and associated caregiving can be complex.

Results
From our Interpretive Description analysis of qualitative interview data from 78 participants (25 caregivers, 37 patients, and 16 healthcare providers [HCPs]), we identified contrasting perspectives about the sharing of caregiver-reported outcome assessments with patients with CRC. Those who preferred open communication with both the patient and caregiver present considered this essential for supporting the caregiver. The participants who preferred private communication without the patient, cited concern about caregiver- and patient-burden and guilt. Recognizing these perspectives, HCPs described strategies used to navigate sensitivities inherent in preferences for open versus private communication.

Conclusions
The integration of caregiver-reported outcomes into cancer care will require careful consideration of caregiver and patient preferences regarding the communication of caregiver assessments to prevent additional burden.
Small vessel vasculitis and dry gangrene secondary to combined CTLA-4 and PD-1 blockade in malignant mesothelioma
Authors: Kefas Joanna , Harwood Catherine , Lewis Myles J. , Szlosarek Peter 
Published: February 2022

Abstract
Background
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with an overall poor prognosis. In October 2020, first line treatment with the PD-1 antagonist nivolumab and the CTLA-4 antagonist ipilimumab for unresectable disease was FDA approved—the first approved treatment regime since 2004. Interim analyses from the phase 3 CHECKMATE-743 study shows improvements in overall survival. Skin-related toxicities are the most commonly reported any-grade treatment-related adverse event from combined nivolumab and ipilimumab therapy.

Case presentation
Here we report a case of a 35-year-old white male who developed digital ischaemia secondary to small vessel vasculitis after receiving PD-1 and CTLA-4 blockade therapy for MPM. His progressive ischaemia became gangrenous, and he required multi-speciality input and treatment with prednisolone, prostacyclin, mycophenolate mofetil and hydroxychloroquine.

Conclusions
Our case highlights the importance of early detection, intervention, and a multispecialty approach to managing such complications in order to minimise the associated morbidity and mortality.
COVID-19 and (gender) inequality in income: the impact of discretionary policy measures in Austria
Authors: Christl Michael , De Poli Silvia , Kucsera Dénes , Lorenz Hanno 
Published: February 2022

AbstractThis paper analyzes the impact of the COVID-19 crisis on household income in Austria, using detailed administrative labor market data, in combination with micro-simulation techniques that enable specific labor market transitions to be modeled. We find that discretionary fiscal policy measures in Austria are key to counteracting the inequality- and poverty-enhancing effect of COVID-19. Additionally, we find that females tend to experience a greater loss in terms of market income. The Austrian tax–benefit system, however, reduces this gender differences. Disposable income has dropped by around 1% for both males and females. By comparison, males profit mainly from short-time work scheme, while females profit especially from other discretionary policy measures, such as the one-off payment for children.
Acinetobacter calcoaceticus SJ19 and Bacillus safensis SJ4, two Algerian rhizobacteria protecting tomato plants against Botrytis cinerea and promoting their growth
Authors: Foughalia Abdelhamid , Bouaoud Yousra , Chandeysson Charlotte , Djedidi Mawahib , Tahirine Mohamed , Aissat Kamel , Nicot Philippe 
Published: February 2022

Abstract
Background
Botrytis cinerea, the causal agent of grey mould, is a polyphagous fungus that infects a wide range of plants, including tomato. In many countries, including Algeria, the management of grey mould is a challenging problem, even with chemical control. This necessitates the search for other strategies. The objective of this study was to evaluate the biocontrol potential of two rhizospheric bacterial isolates for the protection of tomato against B. cinerea.

Results
On tomato plants, the two bacterial isolates consistently provided high levels of protection (on average 72.1% for SJ19 and 52.3% for SJ4). Their applications as a 1:1 mixture reinforced their effect (87.8% protection), indicating their compatibility and a potential use as a consortium. In vitro, the isolates significantly inhibited the mycelial growth of B. cinerea strains, both through direct confrontation in dual-culture assays (12–69% inhibition) and through the production of volatile compounds (36–46% inhibition). The two isolates, applied as seed treatment and as drench on seedlings, also showed strong growth-promoting effects on tomatoes. They substantially increased the length and fresh weight of shoots and roots, as well as stem diameter, leaf number and chlorophyll content, compared to untreated plants.

Conclusion
The two bacteria tested in this study showed a high potential for use as biostimulants and as biofungicides against tomato grey mould.
Large thrombosed portomesenteric venous aneurysm treated with pharmacomechanical thrombolysis combined with TIPS placement
Authors: Kohlbrenner Ryan , Schwertner Adam B , Vogel Alexander R , Conrad Miles , Lokken R Peter 
Published: February 2022

Abstract
Background
Aneurysms are rare anomalies of the portomesenteric venous system. Thrombotic complications of these lesions can lead to mesenteric venous ischemia and bowel infarction, potentially requiring surgical intervention. Herein we describe a case of mesenteric ischemia due to a large thrombosed portomesenteric aneurysm treated with endovascular techniques.

Case presentation
A 37-year-old previously healthy male who presented with abdominal pain to his local emergency department was found to have a thrombosed 12.0 × 5.1 cm portomesenteric venous aneurysm with evidence of mesenteric ischemia on CT. When conservative management with anticoagulation failed, transhepatic pharmacomechanical thrombolysis was initially performed. This was followed by TIPS placement with additional trans-TIPS thrombectomy to improve sluggish portal outflow and prevent re-thrombosis. The patient’s symptoms and imaging findings of ischemia resolved after endovascular therapy. No surgical intervention was required, and the patient was discharged on enoxaparin before being transitioned to apixaban. The TIPS remained patent at 2-year follow-up, with no change in the size of the aneurysm or re-thrombosis noted. The patient’s synthetic liver function was preserved with no evidence of hepatic encephalopathy during the follow-up period.

Conclusions
Endovascular therapies may be used to manage thrombotic complications of portomesenteric venous aneurysms, obviating the need for surgical intervention in selected patients.
Implementing the use of objective medication adherence data in routine clinical practice via the digital CFHealthHub platform: situation analysis and strategy development using the theoretical domains framework
Authors: Girling Carla , Packham Anna , Robinson Louisa , Arden Madelynne A. , Hind Daniel , Wildman Martin J. 
Published: February 2022

Abstract
Background
Preventative inhaled treatments preserve lung function and reduce exacerbations in cystic fibrosis (CF). Self-reported adherence to these treatments is over-estimated. An online platform (CFHealthHub) has been developed with patients and clinicians to display real-time objective adherence data from dose-counting nebulisers, so that clinical teams can offer informed treatment support.

Methods
In this paper, we identify pre-implementation barriers to healthcare practitioners performing two key behaviours: accessing objective adherence data through the website CFHealthHub and discussing medication adherence with patients. We aimed to understand barriers during the pre-implementation phase, so that appropriate strategy could be developed for the scale up of implementing objective adherence data in 19 CF centres.
Thirteen semi-structured interviews were conducted with healthcare practitioners working in three UK CF centres. Qualitative data were coded using the theoretical domains framework (TDF), which describes 14 validated domains to implementation behaviour change.

Results
Analysis indicated that an implementation strategy should address all 14 domains of the TDF to successfully support implementation. Participants did not report routines or habits for using objective adherence data in clinical care. Examples of salient barriers included skills, beliefs in consequences, and social influence and professional roles. The results also affirmed a requirement to address organisational barriers. Relevant behaviour change techniques were selected to develop implementation strategy modules using the behaviour change wheel approach to intervention development.

Conclusions
This paper demonstrates the value of applying the TDF at pre-implementation, to understand context and to support the development of a situationally relevant implementation strategy.