bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Differential lung ventilation with jet ventilation via a bronchial blocker for a patient with a large thoracogastric airway fistula after esophagectomy
Authors: Wu Wenqi , Li Sibei , Song Xiuling , Wang Xia , Wang Yong , Cai Chengyi , Wang Jiyong , Li Yuhui , Ma Wuhua 
Published: November 2022

BackgroundA thoracogastric airway fistula (TGAF) is a rare and potentially fatal complication of esophagectomy for esophageal and cardia carcinomas. Isolation of the fistula and pulmonary separation is necessary during the surgical repair of a tracheal fistula. However, currently, the reported airway management techniques are not suitable for patients with a large TGAF. This case study presents an alternative technique for performing differential lung ventilation in a patient with a thoracogastric airway fistula.Case presentationA 70-year-old man was diagnosed with a thoracogastric airway fistula situated above the carina after esophagectomy, and a thoracoscope-assisted repair of the fistula and pectoralis major myocutaneous flap transplantation were scheduled. The patient could not tolerate one-lung ventilation and the complex intubating operation due to aspiration pneumonia and the size (3.5 cm × 1.7 cm) of the fistula. We, therefore, performed differential lung ventilation in which an extended 6.5#single-lumen endotracheal tube was inserted into the left main bronchus and a 9Fr bronchial blocker was placed in the right main bronchus by using the video-flexible intubation scope. The right lung was selectively inflated with jet ventilation, while positive pressure ventilation was maintained through the left endotracheal tube. The value of SPO2 remained above 95% throughout the operation.ConclusionFor patients with a large thoracogastric airway fistula, differential lung ventilation of a combination of positive pressure ventilation and jet ventilation is useful. Inserting an extended single-lumen endotracheal tube into the left main bronchus and a bronchial blocker into the right main bronchus could be another way of providing differential ventilation for patients with a large thoracogastric airway fistula.
Phytochemical and Antioxidant Profile of the Medicinal Plant Melia azedarach Subjected to Water Deficit Conditions
Authors: Dias Maria Celeste , Pinto Diana C. G. A. , Costa Maria , Araújo Márcia , Santos Conceição , Silva Artur M. S. 
Published: November 2022

Environmental stress triggered by climate change can alter the plant’s metabolite profile, which affects its physiology and performance. This is particularly important in medicinal species because their economic value depends on the richness of their phytocompounds. We aimed to characterize how water deficit modulated the medicinal species Melia azedarach’s lipophilic profile and antioxidant status. Young plants were exposed to water deficit for 20 days, and lipophilic metabolite profile and the antioxidant capacity were evaluated. Leaves of M. azedarach are rich in important fatty acids and oleamide. Water deficit increased the radical scavenging capacity, total phenol, flavonoids, and catechol pools, and the accumulation of β-sitosterol, myo-inositol, succinic acid, sucrose, d-glucose and derivatives, d-psicofuranose, d-(+)-fructofuranose, and the fatty acids stearic, α-linolenic, linoleic and palmitic acids. These responses are relevant to protecting the plant against climate change-related stress and also increase the nutritional and antioxidant quality of M. azedarach leaves.
Intraoperative Urine Oxygen in Cardiac Surgery and 12-Month Outcomes
Authors: Parry Samuel R. , Silverton Natalie A. , Hall Isaac E. , Stoddard Gregory J. , Lofgren Lars , Kuck Kai 
Published: November 2022

Key Points

Low intraoperative urinary oxygen during cardiac surgery is associated with increased risk of poor 12-month outcomes.With decreasing urinary oxygen thresholds, the risk of poor 12-month outcomes increases.
A Machine Learning Model to Predict Diuretic Resistance
Authors: Mercier Joey A. , Ferguson Thomas W. , Tangri Navdeep 
Published: November 2022

Key Points

Our machine learning algorithm was able to quickly predict those at risk for diuretic resistance using common variables.Our machine learning algorithm could easily be implemented within electrical medical software (or as an online calculator).Our study provides a proof of concept/framework for the development of future machine learning models.

Background
Volume overload is a common complication encountered in hospitalized patients, and the mainstay of therapy is diuresis. Unfortunately, the diuretic response in some individuals is inadequate despite a typical dose of loop diuretics, a phenomenon called diuretic resistance. An accurate prediction model that predicts diuretic resistance using predosing variables could inform the right diuretic dose for a prospective patient.

Methods
Two large, deidentified, publicly available, and independent intensive care unit (ICU) databases from the United States were used—the Medical Information Mart for Intensive Care III (MIMIC) and the Philips eICU databases. Loop diuretic resistance was defined as <1400 ml of urine per 40 mg of diuretic dose in 24 hours. Using 24-hour windows throughout admission, commonly accessible variables were obtained and incorporated into the model. Data imputation was performed using a highly accurate machine learning method. Using XGBoost, several models were created using train and test datasets from the eICU database. These were then combined into an ensemble model optimized for increased specificity and then externally validated on the MIMIC database.

Results
The final ensemble model was composed of four separate models, each using 21 commonly available variables. The ensemble model outperformed individual models during validation. Higher serum creatinine, lower systolic blood pressure, lower serum chloride, higher age, and female sex were the most important predictors of diuretic resistance (in that order). The specificity of the model on external validation was 92%, yielding a positive likelihood ratio of 3.46 while maintaining overall discrimination (C-statistic 0.69).

Conclusions
A diuretic resistance prediction model was created using machine learning and was externally validated in ICU populations. The model is easy to use, would provide actionable information at the bedside, and would be ready for implementation in existing electronic medical records. This study also provides a framework for the development of future machine learning models.
Hubungan Kekerabatan Bahasa Pakpak dan Alas: Kajian Linguistik Historis Komparatif
Authors: Sinaga Lara Desma , Widyawati Dwi 
Published: November 2022

Languages that are in one proto are thought to still have language kinship. This study will describe how the kinship of the Pakpak and Alas languages and find out the time of separation and the age of the Pakpak and Alas languages. The methods used are qualitative and quantitative methods. From the results of the study, it was found that the Pakpak and Alas languages have a kinship relationship in the family class because they are in the range of 44%. This indicates that the Pakpak and Alas languages are in the same proto and have family relationships. Pakpak and Alas languages are considered to be the same language around 1891 thousands of years ago. In addition, the Pakpak and Alas languages are thought to have started to separate from a single proto-language around the year 131 ADKeywords: Alas language; kinship; Pakpak language; comparativeAbstrakBahasa yang berada pada satu proto diduga masih memiliki kekerabatan Bahasa. Penelitian ini akan menggambarkan bagaimanakah hubungan kekerabatan bahasa Pakpak dan Alas serta mengetahui waktu pisah dan usia bahasa Pakpak dan Alas. Metode yang digunakan adalah metode kualitatif dan kuantitatif. Dari hasil penelitian didapati bahwa bahasa Pakpak dan bahasa Alas memiliki hubungan kekerabatan pada kelas family karena berada pada kisaran 44% Ini menunjukkan bahwa bahasa Pakpak dan Alas berada pada satu proto yang sama dan memiliki hubungan family(keluarga). Bahasa Pakpak dan Alas diperhitungkan merupakan satu bahasa yang sama sekitar 1891 ribuan tahun yang lalu. Selain itu, bahasa Pakpak dan Alas diperkirakan mulai berpisah dari satu bahasa proto kira lira tahun 131MasehiKata Kunci : bahasa Pakpak; bahasa Alas; kekerabatan; komparatif
IMPLEMENTASI METODE APEL DALAM MENGHAFAL JUZ ‘AMMA GUNA MENINGKATKAN DAYA INGAT SANTRI MADIN CHILDERN
Authors: Ali Mohtarom Ali Mohtarom 
Published: November 2022

Metode merupakan seperangkat cara dan teknik yang digunakan oleh pendidik dalam proses pembelajaran, misalkan metode apel. Apel tersebut dilaksanakan setiap hari sebelum masuk kelasnya masing-masing, yang mana apel ini mampu melatih dalam menghafal dan daya ingat santri. Maka dari itu peneliti mencoba untuk mengungkap adanya implementasi metode apel dalam menghafal Juz ‘amma guna meningkatkan daya ingat santri. rancangan penelitian ini menggunakan penelitian kualitatif.Adapun sumber data dan pengumpulan data akan diperoleh dari data primer yang diperoleh dari hasil observasi dan wawancara/interview serta data sekunder yang diperoleh lewat orang lain atau dokumen-dokumen. Sedangkan analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif, yang mana data yang dikumpulkan berupa kata-kata, gambar dan bukan angka.Implementasi metode apel yang diterapkan di Madin Childern sangat baik dan memuaskan. Dan sudah dikatakan dapat meningkatkan perkembangan santri dalam hal menghafal, selain itu juga dapat melatih santri untuk membiasakan membaca bacaan-bacaan tersebut dan menerapkannya dalam kehidupan sehari-hari, karena bacaan yang dibaca dalam apel, meliputi do’a-do’a harian, asmaul husna dan surat-surat pendek (Juz ‘amma). Seluruh santri diwajibkan mengikuti apel, meskipun tidak keseluruhan dari santri yang ikut membacanya karena mereka masih belum lancar dalam membacanya, misalkan bacaan surat-surat pendek (Juz ‘amma). Untuk tingkat daya ingat pada santri yang menghafal Juz ‘amma dasarnya masih minim kira-kira 60% karena untuk anak yang seusia dini butuh penerapan metode pembiasaan, salah satunya dengan menggunakan metode apel. Dengan mengulang-ngulang bacaannya maka tingkat kemampuan daya ingat santri meningkat kira-kira 85%, jadi santri lebih mudah didalam menghafal dan mengingatnya.
The scam of the research world: the predatory practices
Authors: Saleem Huma , Iqbal Almas 
Published: November 2022

The authors have highlighted the ever-spreading menace of fake research and predatory journalism in the medicine. The lack of incentives and facilities for genuine research, coupled with compulsion to publish a minimum number of papers for promotions, have forced the authors to adopt the short-cut and choose the journals, which are willing to publish for money, without rigorous peer-review. This tendency can only be curtailed by strict adherence to the rules already set by international agencies.
Key words: Access to Information; Authorship; Editorial Policies; Fraud; Open Access Publishing / standards; Peer Review; Scientific Misconduct
Citation: Saleem H, Iqbal A. The scam of the research world: the predatory practices. Anaesth. pain intensive care 2022;26(4):430-432; DOI: 10.35975/apic.v26i4.1943
Received: June 14, 2022; Reviewed: June 22, 2022; Accepted: July 06, 2022
Analgesic efficacy of the erector spinae plane block using bupivacaine vs. bupivacaine/magnesium sulphate in patients undergoing lumbar spine surgery: a randomized, double-blinded comparative study
Authors: Abdelbadie Mohamed 
Published: November 2022

Abstract
Background & Objectives: Postoperative pain is one of the most troublesome pains for the surgical patient, and is one of the causes of morbidity and prolonged hospital stay. Opiates and non-steroidal anti-inflammatory drugs have been routinely used across the world. Recent resurge of regional anesthetic techniques offer some advantages, especially reduced post-operative nausea and vomiting and less sedation.
We compared the efficacy of bupivacaine with a combination of bupivacaine/magnesium sulphate for the Erector Spinae Plane (ESP) block in patients for postoperative pain undergoing lumbar spinal fusion under general anesthesia.
Methodology: A total of 30 ASA-I and II patients, 20-60 y old, who undergoing lumbar spinal fusion were enrolled. They were randomly divided into two groups; Group B (n = 15) to receive bupivacaine 0.25 percent, 20 mL injected on each side to provide ESP block; and Group BMG (n = 15): to receive 20 mL of 0.25 percent bupivacaine plus 500 mg magnesium sulphate, injected on each side for ESP block.
The parameters measured included; the surgery time, non-invasive mean blood pressure during surgery, postoperative heart rate at 1, 6, 12, and 24 h, The time to first request for analgesics time after surgery referred to as the postoperative period (h). Postoperative total analgesic (pethidine needed per 24h) required and postoperative pain at rest and on moving, measured with VAS (Visual Analogue Scale) at the 1st, 6th, 12th, and 24th h.
Results: Both at rest and through moving the VAS (Visual Analogue Scale) among both groups. No significant difference could be seen at the first, sixth, twelfth, and twenty-fourth hours. The time to the first request for analgesics was significantly prolonged in the Group BMG than the Group B. The total analgesic need after surgery was significantly lower in Group BMG than the Group B.
Conclusion: The use of a combination of bupivacaine plus magnesium for bilateral erector spinae plane block after lumbar spinal fusion surgery is better in terms of prolonged postoperative analgesia and reducing the opioid use as compared to bupivacaine alone in patients undergoing lumbar spinal fusion under general anesthesia.
Abbreviations: ESP - Erector spinae plane; VAS - Visual Analogue Scale; NSAIDs - Non-steroidal anti-inflammatory drugs;
Key words: Adult; Analgesia; Analgesics, Opioid / therapeutic use; Bupivacaine; Humans; Lumbar spine; Magnesium sulfate; Nerve Block; Pain, Postoperative / drug therapy; Pain, Postoperative / prevention & control; Paraspinal Muscles
Citation: Abdelbadie M. Analgesic efficacy of the erector spinae plane block using bupivacaine vs. bupivacaine/magnesium sulphate in patients undergoing lumbar spine surgery: a randomized, double-blinded comparative study. Anaesth. pain intensive care 2022;26(4):439-444; DOI: 10.35975/apic.v26i4.1945
Received: April 17, 2022; Reviewed: May 06, 2022; Accepted: June 17, 2022
The comfort level of the physicians involved in the management of intensive therapy at the COVID-19 referral hospitals
Authors: Lubis Andriamuri Primaputra , MD S. Ningrum Ika Pratiwi Putri, 
Published: November 2022

Background & Objective: Novel Coronavirus-2019, the cause of COVID-19, was first discovered at the end of 2019 in Wuhan City. Analysis of confirmed cases in China states that 7%-26% of patients with severe disease required intensive care. The high number of cases of COVID-19 forced the ‘North Sumatra Indonesian Society of Anesthesiology & Intensive Therapy (NSISAIT) COVID-19 Task Force’ to manage and monitor appropriate intensive therapy at selected referral hospitals.
We conducted this study to know the comfort level of the NSISAIT COVID-19 Task Force during the management of intensive therapy at the COVID-19 referral hospitals.
Methodology: This study used a descriptive observational method with a cross sectional design. A questionnaire was designed and circulated by electronic means among the physicians involved in management of COVID-19 patients as a part of NSISAIT COVID-19 Task Force. The responses received were grouped and categorized using MS Excel software.
Results: The results of the study showed that the comfort level of the NSISAIT COVID-19 Task Force was categorized as satisfactory by almost half of the respondents. The COVID-19 handling was categorized as very good by 34 (65.4%) respondents; 25 (48.1%) felt a fairly good level of security, 21 (40.4%) answered that the facilities and infrastructure at the referral hospitals were quite good, 28 (53.8%) respondents received a very good award; and 27 respondents (51.9%) carried out intensive therapy management quite well.
Conclusion: The comfort level of the NSISAIT COVID-19 Task Force in the management of intensive therapy at the COVID-19 referral hospitals was in the comfortable category.
Abbreviations: NSISAIT - North Sumatra Indonesian Society of Anesthesiology & Intensive Therapy; HCW - healthcare workers; PPE - personal protective equipment;
Key words: COVID-19; Intensive therapy; Comfort level
Citation: Lubis AP, Putri NIP. The comfort level of the physicians involved in the management of intensive therapy at the COVID-19 referral hospitals. Anaesth. pain intensive care 2022;26(4):458-462.
DOI: 10.35975/apic.v26i4.1948
Received: February 15, 2022; Reviewed: February 25, 2022; Accepted: June 06, 2022
Effects of the COVID-19 pandemic on the approach to emergency surgery: a comparative study
Authors: Akcaalan Yasemin , Erkilic Ezgi , Gulec Handan , Gumus Tulin , Ozturk Levent , Kayan Gizem , Kanbak Orhan , Celik Nuri 
Published: November 2022

Background & objective: Corona pandemic has had profound effects on the practice of healthcare delivery across the globe. The institutional practices and protocols had to be rewritten to cope up with the surge of corona patients and to save the staff and the non-corona patients. We evaluated the emergency surgery cases during the first wave of COVID-19 after the decision to stop elective surgeries, in regard to differences in terms of case distribution, patient profile, anesthesia methods used and the management, and compared with an equivalent period before the pandemic.
Methodology: Patient files related to emergency surgery from October-November 2019 and April-May 2020, were retrospectively evaluated. Assessment parameters included age, gender, surgical discipline, ASA score, type of anesthesia, time to discharge, reoperation, laparoscopic or open surgery.
Results: The most common surgical cases in both periods belonged to general surgery. While the number of patients in ASA-I decreased during the COVID period, those in ASA-II increased. We found that while general anesthesia was preferred in majority of the surgeries during the non-COVID period, spinal anesthesia gained popularity in the COVID period (p < 0.05).
Conclusion: The decrease in the number of patients with ASA-I indicates a change in the surgeons’ priorities in emergency surgery cases. Although there is a worldwide approach to the use of laparoscopic surgery, the use of open surgical techniques increased in our hospital.
Key words: Covid-19; Pandemic, Emergency surgery
Citation: Akcaalan Y, Erkilic E, Gulec H, Gumus T, Ozturk L, Kayan G, Kanbak O, Celik N. Effects of the COVID-19 pandemic on the approach to emergency surgery: a comparative study. Anaesth. pain intensive care 2022;26(3):469-473; DOI: 10.35975/apic.v26i4.1949
Received: Sep 29, 2021; Reviewed: Jan 10, 2022; Accepted: Mar 26, 2022
Evaluation of prognostic factors associated with intensive care unit mortality in patients with hematopoietic stem cell transplantation
Authors: Hizarci Burcu , Sadri Sevil 
Published: November 2022

Background & objective: Although the outcome of patients admitted to ICUs have considerably improved in recent years, hematopoietic stem cell transplantation (HSCT) continues to be significantly associated with mortality.
We studied the prognostic factors associated with ICU mortality after HSCT. The Acute Physiological and Chronic Health Evaluation II (APACHE II) was used as a prognostic scoring system.
Methods: Within the scope of the research, the clinical and laboratory data of 52 patients who were admitted to the ICU after undergoing HSCT between 2013 and 2019 were analyzed retrospectively.
Results: Mortality risk was found to be 4.22 times higher in patients who received mechanical ventilation (MV) within the first 24 h (P = 0.047), 18.37 times higher in patients who received total parenteral nutrition (TPN) support (P = 0.007), and 158.17 times higher in recipients of vasopressor drug support compared to those who did not (P < 0.001). It was found that a one unit increase in GCS score decreased mortality risk by 0.58 fold (P = 0.015). Additionally, a one unit increase in heart rate was found to increase mortality risk by 1.03 fold (P = 0.010). Whereas, one unit increases in systolic blood pressure or diastolic blood pressure decreased the mortality risk by 0.91 and 0.92 fold, respectively (P = 0.001 and P = 0.002). Mortality was not associated with APACHE II or graft-versus-host disease.
Conclusion: Receiving MV, TPN or vasopressor treatment, and having lower GCS, higher heart rate, lower systolic and diastolic blood pressure were associated with an increase in the risk of ICU mortality in HSCT recipients admitted to the ICU.
Abbreviations: HSCT - hematopoietic stem cell transplantation; TPN - total parenteral nutrition; APACHE II - Acute Physiological and Chronic Health Evaluation II: GVHT - graft-versus-host disease; ICU - intensive care unit; GCS – Glasgow Coma Scale; MODS - Multiple organ dysfunction syndrome
Key words: Hematopoietic stem cell transplantation; Intensive care; Mortality; Mechanical ventilation, parenteral nutrition; MV- mechanical ventilation;
Citation: Tunay B, Sadri S. Evaluation of prognostic factors associated with intensive care unit mortality in patients with hematopoietic stem cell transplantation. Anaesth. pain intensive care 2022;26(4):480-487 ; DOI: 10.35975/apic.v26i4.1951
Received: Nov 12, 2021; Reviewed: May 11, 2022; Accepted: July 08, 2022