bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution of multiple chalazia in eyelids of pediatrics requiring surgery in southeast China: a hospital-based cross-sectional study
Authors: Zheng Xiao-Yu , Dorazio Robert M , Choy Bonnie Nga Kwan , Wang Ting-Yan , Zhao Su-Juan , Zhao Zheng-Yan 
Published: May 2022

BackgroundMultiple chalazia are common in children, and many are treated by surgery. However, the distribution of different types of multiple chalazia has not been studied. This research aimed to investigate the location and number of multiple chalazia in pediatrics who need surgical treatments.MethodsPatients with multiple chalazia treated by incision and curettage surgery (I&C) in a tertiary children’s hospital between June and December 2016 were reviewed. Demographic data, locations, and numbers of chalazia were recorded. Data were analyzed using generalized linear models of the counts and the occurrences of chalazia. Hypotheses were tested using likelihood ratio tests appropriate for each type of data.ResultsThe study included 128 subjects, most of which were 1–3 years old. The majority of patients had bilateral chalazia (95.3%), and the proportions of patients with internal, external, and marginal chalazion differed dramatically (99.2%, 61.7%, and 2.3%, respectively). The number of internal and external chalazia did not vary significantly with gender, age, or residence of the patients. Internal chalazia were located more frequently in the upper lids (p<0.001). External chalazia showed no preference of localization. The average number of internal chalazia in each eyelid did not relate to the presence of external chalazia.ConclusionsMultiple chalazia are common among younger children in southeast China. The anatomical distribution varies depending on the type of chalazion. Multiple chalazia often occur bilaterally and internally. If doctors are more aware of the anatomical distribution of chalazia, this might result in a higher success rate of I&C.
Toward Improving the Quality of Mutation Operator and Test Case Effectiveness in Higher-Order Mutation Testing
Authors: Do Van-Nho , Nguyen Quang-Vu , Nguyen Thanh-Binh 
Published: May 2022

Currently, there are many research studies that apply and improve mutation testing techniques including traditional mutation testing or first-order mutation testing, and higher-order mutation testing (HOMT) for evaluating the quality of the set of test data in particular, and the quality of test suites in general. The results of those studies have proven the effectiveness of mutation testing in the field of software testing. Mutation testing allows the quality of test cases to be automatically evaluated, thereby helping the testers to improve the quality in the design and execution of the software testing. Besides, these studies have also pointed out the main barriers in applying mutation testing techniques in practice. However, we are the first to introduce a method that can reduce the cost, but keep the quality of testing activity based on evaluating the quality of the mutation operator as well as the quality of the test cases. In this paper, we concentrate on two problems regarding higher-order mutation testing: Evaluating the quality of mutation operators as well as generated mutants and prioritizing test cases based upon its capability of killing mutants. This may help developers allocate suitably their resources during testing phase. The study of this paper is an extended version of our previous study titled “Evaluating Mutation Operator and Test Case Effectiveness by Means of Mutation Testing”, which is published in the proceedings of the 13th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2021 (V. N. Do, Q. V. Nguyen and T. B. Nguyen, Evaluating Mutation Operator and Test Case Effectiveness by Means of Mutation Testing, in Intelligent Information and Database Systems. ACIIDS 2021, eds. N. T. Nguyen, S. Chittayasothorn, D. Niyato and B. Trawiński. Lecture Notes in Computer Science, Vol. 12672 (Springer, Cham), https://doi.org/10.1007/978-3-030-73280-6_66 ) to confirm the usefulness of our proposed method.
Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes
Authors: Vaura Felix , Kim Hyunkyung , Udler Miriam S. ,   FinnGen*, Salomaa Veikko , Lahti Leo , Niiranen Teemu 
Published: May 2022

Background:
Hypertension comprises a heterogeneous range of phenotypes. We asked whether underlying genetic structure could explain a part of this heterogeneity.

Methods:
Our study sample comprised N=198 148 FinnGen participants (56% women, mean age 58 years) and N=21 168 well-phenotyped FINRISK participants (53% women, mean age 50 years). First, we identified genetic hypertension components with an unsupervised Bayesian non-negative matrix factorization algorithm using public genome-wide association data for 144 genetic hypertension variants and 16 clinical traits. For these components, we computed their (1) cross-sectional associations with clinical traits in FINRISK using linear regression and (2) longitudinal associations with incident adverse outcomes in FinnGen using Cox regression.

Results:
We observed 4 genetic hypertension components corresponding to recognizable clinical phenotypes: obesity (high body mass index), dyslipidemia (low high-density lipoprotein cholesterol and high triglycerides), hypolipidemia (low low-density lipoprotein cholesterol and low total cholesterol), and short stature. In FINRISK, all hypertension components had robust associations with their respective clinical characteristics. In FinnGen, the Obesity component was associated with increased diabetes risk (hazard ratio per 1 SD increase 1.08 [Bonferroni corrected CI, 1.05–1.10]) and the Hypolipidemia component with increased autoimmune disease risk (hazard ratio per 1 SD increase 1.05 [Bonferroni corrected CI, 1.03–1.07]). In addition, all hypertension components were related to both hypertension and cardiovascular disease.

Conclusions:
Our unsupervised analysis demonstrates that the genetic basis of hypertension can be understood as a mixture of 4 broad, clinically interpretable components capturing disease heterogeneity. These components could be used to stratify individuals into specific genetic subtypes and, therefore, to benefit personalized health care and pharmaceutical research.
Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study
Authors: Goldberg Ronald B. , Orchard Trevor J. , Crandall Jill P. , Boyko Edward J. , Budoff Matthew , Dabelea Dana , Gadde Kishore M. , Knowler William C. , Lee Christine G. , Nathan David M. , Watson Karol , Temprosa Marinella ,   on behalf of the Diabetes Prevention Program Research Group*
Published: May 2022

Background:
Lifestyle intervention and metformin have been shown to prevent diabetes; however, their efficacy in preventing cardiovascular disease associated with the development of diabetes is unclear. We examined whether these interventions reduced the incidence of major cardiovascular events over a 21-year median follow-up of participants in the DPP trial (Diabetes Prevention Program) and DPPOS (Diabetes Prevention Program Outcomes Study).

Methods:
During DPP, 3234 participants with impaired glucose tolerance were randomly assigned to metformin 850 mg twice daily, intensive lifestyle or placebo, and followed for 3 years. During the next 18-year average follow-up in DPPOS, all participants were offered a less intensive group lifestyle intervention, and unmasked metformin was continued in the metformin group. The primary outcome was the first occurrence of nonfatal myocardial infarction, stroke, or cardiovascular death adjudicated by standard criteria. An extended cardiovascular outcome included the primary outcome or hospitalization for heart failure or unstable angina, coronary or peripheral revascularization, coronary heart disease diagnosed by angiography, or silent myocardial infarction by ECG. ECGs and cardiovascular risk factors were measured annually.

Results:

Neither metformin nor lifestyle intervention reduced the primary outcome: metformin versus placebo hazard ratio 1.03 (95% CI, 0.78–1.37;
P
= 0.81) and lifestyle versus placebo hazard ratio 1.14 (95% CI, 0.87–1.50;
P
= 0.34). Risk factor adjustment did not change these results. No effect of either intervention was seen on the extended cardiovascular outcome.

Conclusions:
Neither metformin nor lifestyle reduced major cardiovascular events in DPPOS over 21 years despite long-term prevention of diabetes. Provision of group lifestyle intervention to all, extensive out-of-study use of statin and antihypertensive agents, and reduction in the use of study metformin together with out-of-study metformin use over time may have diluted the effects of the interventions.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifiers: DPP (NCT00004992) and DPPOS (NCT00038727).
How Possessing, Lovesick and Avenging Jinns are Exorcised in Contemporary Sweden
Authors: Marlow Michael 
Published: May 2022

Abstract
This article investigates the practice of ruqya (Islamic exorcism) in Europe. First, the basic presuppositions of ruqya – the clientele, the jinns, and why they might possess humans – are explained. This is followed by an in-depth example of how ruqya is currently conducted in Sweden and a general model outlining nine stages is suggested for analysing ruqya. Finally, the article considers whether the practice of ruqya in Europe differs from the way it is practised in Muslim countries. Ruqya in Europe seems to include less physical violence, and it is implicitly used to counter Muslim assimilation and uphold orthodox Islamic values.
The Control of Anteromedial Rotatory Instability Is Improved With Combined Flat sMCL and Anteromedial Reconstruction
Authors: Behrendt Peter , Herbst Elmar , Robinson James R. , von Negenborn Leslie , Raschke Michael J. , Wermers Jens , Glasbrenner Johannes , Fink Christian , Herbort Mirco , Kittl Christoph 
Published: May 2022

Background: Both the superficial medial collateral ligament (sMCL) and the deep MCL (dMCL) contribute to the restraint of anteromedial (AM) rotatory instability (AMRI). Previous studies have not investigated how MCL reconstructions control AMRI. Purpose/Hypothesis: The purpose was to establish the optimal medial reconstruction for restoring normal knee kinematics in an sMCL- and dMCL-deficient knee. It was hypothesized that AMRI would be better controlled with the addition of an anatomically shaped (flat) sMCL reconstruction and with the addition of an AM reconstruction replicating the function of the dMCL. Study Design: Controlled laboratory study. Methods: A 6 degrees of freedom robotic system equipped with a force-torque sensor was used to test 8 unpaired knees in the intact, sMCL/dMCL sectioned, and reconstructed states. Four different reconstructions were assessed. The sMCL was reconstructed with either a single-bundle (SB) or a flattened hamstring graft aimed at better replicating the appearance of the native ligament. These reconstructions were tested with and without an additional AM reconstruction. Simulated laxity tests were performed at 0°, 30°, 60°, and 90° of flexion: 10 N·m valgus rotation, 5 N·m internal and external rotation (ER), and an AM drawer test (combined 134-N anterior tibial drawer in 5 N·m ER). The primary outcome measures of this force-controlled setup were anterior tibial translation (ATT; in mm) and axial tibial rotation (in degrees). Results: Sectioning the sMCL/dMCL increased valgus rotation, ER, and ATT with the simulated AM draw test at all flexion angles. SB sMCL reconstruction was unable to restore ATT, valgus rotation, and ER at 30°, 60°, and 90° of flexion to the intact state ( P < .05). Flat MCL reconstruction restored valgus rotation at all flexion angles to the intact state ( P > .05). ER was restored at all angles except at 90°, but ATT laxity in response to the AM drawer persisted. Addition of an AM reconstruction improved control of ATT relative to the intact state at all flexion angles ( P > .05). Combined flat MCL and AM reconstruction restored knee kinematics closest to the intact state. Conclusion: In a cadaveric model, AMRI resulting from an injured sMCL and dMCL complex could not be restored by an isolated SB sMCL reconstruction. A flat MCL reconstruction or an additional AM procedure, however, better restored medial knee stability. Clinical Relevance: In patients evaluated with a combined valgus and AM rotatory instability, a flat sMCL and an additional AM reconstruction may be superior to an isolated SB sMCL reconstruction.
Rates of Return to Manual Labor After Arthroscopic Rotator Cuff Repair
Authors: Green Clare K. , Scanaliato John P. , Dunn John C. , Rosner Rachel S. , Parnes Nata 
Published: May 2022

Background: Rotator cuff tears represent a significant cause of shoulder pain and dysfunction in the United States. The development of these injuries is associated with older patient age and higher levels of physical activity; however, data regarding the rate of return to work after arthroscopic rotator cuff repair in patients older than 50 years of age who have physically strenuous jobs is inconclusive. Purpose/Hypothesis: The purpose of this study was to report short term outcomes and return to work rates after arthroscopic rotator cuff repair in a cohort of patients aged 50 to 60 years working in manual labor jobs. It was hypothesized that arthroscopic rotator cuff repair would result in good functional outcomes for these patients and allow for return to work rates in excess of 80%. Study Design: Case series; Level of evidence, 4. Methods: Preoperative and final evaluations including the pain visual analog scale (VAS), the Single Assessment Numeric Evaluation (SANE), and the American Shoulder and Elbow Surgeons (ASES) Shoulder Score were collected. A total of 73 patients were screened for inclusion. Nineteen patients were outside of the inclusion age range, 2 underwent exclusionary concomitant procedures, and 4 patients were lost to follow up, leaving a total of 48 patients with a mean follow up of 34.02 months (range, 24-67 months) available for analysis. None of the patients were involved in a workers’ compensation claim. Subgroup analysis was performed to determine if arm dominance or tear size affected surgical outcomes or return to work rates. Results: After arthroscopic rotator cuff repair, 43 of 48 patients (89.6%) were able to return to manual labor positions. Tears were classified using the Southern California Orthopaedic Institute Classification at the time of repair as massive (C4) in 9 patients (18.75%), large (C3) in 13 patients (27.08%), medium (C2) in 21 patients (43.75%), and small (C1) in 5 patients (10.42%). At latest follow up, the mean VAS decreased from 8.0 ± 1.81 to 0.46 ± 1.20, the average SANE increased from 47.50 ± 18.59 to 91.88 ± 12.30, and the average ASES score improved from 39.58 ± 10.71 to 93.44 ± 11.97 ( P < .0001). Outcomes did not differ between patients who underwent surgery on their dominant shoulder and those who underwent surgery on their nondominant shoulder. The overall postoperative complication rate was 8.33%. Conclusion: Arthroscopic rotator cuff repair portended favorable outcomes and high rates of return to work in this cohort of manual laborers, with 89.6% of patients able to return to work.
Chinese and Western Philosophical and Ethical Perspectives: Différance Rather Than Incommensurability or Sameness
Authors: Sigurðsson Geir 
Published: May 2022

AbstractThis experimental article claims that relatively recent trends in Western philosophy provide a much more open approach to philosophies originating in nonwestern traditions, including the Chinese, than found in most mainstream Western philosophy. More specifically, I argue that a slightly modified version of Jacques Derrida's concept of différance offers a hermeneutic parallel to native Chinese philosophical approaches to interpretation. These converge in the view that Western and Chinese philosophies cannot be reduced to the other in conceptual terms and that a finalized meaning or interpretation of each is a priori unattainable, thus providing a future opening for – and even integration of – a Chinese-Western dialogue in global philosophy and ethics.
Racial and Ethnic Differences in the Prevalence of Do-Not-Resuscitate Orders among Older Adults with Severe Traumatic Brain Injury
Authors: Hatfield Jordan , Fah Megan , Girden Alex , Mills Brianna , Ohnuma Tetsu , Haines Krista , Cobert Julien , Komisarow Jordan , Williamson Theresa , Bartz Raquel , Vavilala Monica , Raghunathan Karthik , Tobalske Anwen , Ward Joshua , Krishnamoorthy Vijay 
Published: May 2022

Background Older adults suffering from traumatic brain injury (TBI) are subject to higher injury burden and mortality. Do Not Resuscitate (DNR) orders are used to provide care aligned with patient wishes, but they may not be equitably distributed across racial/ethnic groups. We examined racial/ethnic differences in the prevalence of DNR orders at hospital admission in older patients with severe TBI. Methods We conducted a retrospective cohort study using the National Trauma Databank (NTDB) between 2007 to 2016. We examined patients ≥ 65 years with severe TBI. For our primary aim, the exposure was race/ethnicity and outcome was the presence of a documented DNR at hospital admission. We conducted an exploratory analysis of hospital outcomes including hospital mortality, discharge to hospice, and healthcare utilization (intracranial pressure monitor placement, hospital LOS, and duration of mechanical ventilation). Results Compared to White patients, Black patients (OR 0.48, 95% CI 0.35-0.64), Hispanic patients (OR 0.54, 95% CI 0.40-0.70), and Asian patients (OR 0.63, 95% CI 0.44-0.90) had decreased odds of having a DNR order at hospital admission. Patients with DNRs had increased odds of hospital mortality (OR 2.16, 95% CI 1.94-2.42), discharge to hospice (OR 2.08, 95% CI 1.75-2.46), shorter hospital LOS (−2.07 days, 95% CI −3.07 to −1.08) and duration of mechanical ventilation (−1.09 days, 95% CI −1.52 to −0.67). There was no significant difference in the utilization of ICP monitoring (OR 0.94, 95% CI 0.78-1.12). Conclusions We found significant racial and ethnic differences in the utilization of DNR orders among older patients with severe TBI. Additionally. DNR orders at hospital admission were associated with increased in-hospital mortality, increased hospice utilization, and decreased healthcare utilization. Future studies should examine mechanisms underlying race-based differences in DNR utilization.
Urban-rural disparities in hypertension management among middle-aged and older patients: Results of a 2018 Chinese national study
Authors: Tam Hon Lon , Chung Siu Fung , Wang Qun 
Published: May 2022

Objectives Hypertension is a well-known global risk factor associated with significant morbidity and mortality. Medication use and urban-rural disparities in medication usage patterns affect hypertension management. We investigated patient characteristics across different geographical areas to determine factors that affect medication use among Chinese patients aged ≥ 45 years, diagnosed with hypertension. Methods Data were extracted from the China Health and Retirement Longitudinal Study 2018. We recorded differences in medication use, advice from healthcare providers, and health-related behaviors between urban and rural areas. Results The study included 2115 patients with hypertension (mean age 62.06 years). Advice received and medication use were significantly lower in patients from rural areas than in those from urban areas. Our findings showed that urban residence, comorbidities, advice regarding lifestyle changes, and smoking were positive predictors of medication use, whereas alcohol consumption and regular exercise reduced the likelihood of medication use. Discussion We observed urban-rural disparities in hypertension management, and several strategies, including distribution of reminders and written materials can be integrated into current clinical practice to improve the rate of medication use among rural residents with hypertension.
Hip-Spine Relationship between Sagittal Balance of the Lumbo-Pelvi-Femoral Complex and Hip Extension Capacity: An EOS Evaluation in a Healthy Caucasian Population
Authors: Kouyoumdjian Pascal , Mansour Jad , Haignère Vincent , Demattei Christophe , Maury Etienne , George David , Coulomb Remy 
Published: May 2022

Study Design A prospective study of healthy volunteers Objectives The influence of the sagittal alignment of the spine and its influence on the extension reserve have been reported in the literature. However, specific analysis of the intrinsic coxofemoral and extrinsic pelvic component in subjects without any spinal or hip pathologies remains poorly reported. The aim of this study was to categorize the hip extension capacity, or extension reserve (ER), in relation to spinal sagittal alignment whilst standing, in a young healthy population. We hypothesized that the global extension reserve (GER) of the hip joint was influenced by the sagittal spinopelvic alignment. Methods We evaluated the ER of 120 healthy Caucasian volunteers (56 females (46.7%), 74 males (53.3%); mean age 25.6 years), using low dose radiographs from an EOS® X-ray imaging system in 2 functional positions; neutral standing position and in a forward lunge position. The GER is defined as the sum of the intrinsic (hip) extension reserve (IER) and the extrinsic (pelvic) extension reserve (EER). Cases were grouped into 4 sagittal alignment subtypes according to the Roussouly classification, and analyzed. Results Global extension reserve values were not significantly different between the 4 Roussouly subtypes ( P = .094), nor between patients with a sacral slope (SS) <35° (types 1/2) and ≥ 35° (type 3/4) ( P = .837). Statistically significant differences were seen between IER in each subtype ( P = .015), and EER ( P = .006). No difference in ER was seen between subtypes regarding pelvic incidence (PI). Conclusion An inverse relationship was found between IER and EER among Roussouly subtypes. The range of motion of the pelvis and the hip joint was higher in patients with a greater sacral slope.
Exploring temporal variability in travel patterns on public transit using big smart card data
Authors: Zhao Xia , Cui Mengying , Levinson David 
Published: May 2022

Passengers generate travel behaviours on public transit, whose variations deserve an exploration with an aim to guide daily-updated managements. In this study, we investigate temporal variability in travel patterns for over 3.3 million passengers across 120 days who use public transit in Beijing. Temporal variability is characterized by a series of features in terms of space coverage, travel distance and travel frequency, based on which, passengers are clustered into two types, that is, commuters with daily travel routines, and non-commuters who do not. How, and to which extent, they change travel patterns over time are examined, with using approaches concerning multivariate regression and curve fitting. Results show that, (1) commuters are more likely to travel longer but cover less territory than non-commuters on weekdays, while the opposite patterns occur on weekends. The variation of day of week affects commuters less, compared to non-commuters, due to more fixed schedules, as expected; (2) travel distance and frequency are found to increase faster, more linearly, than space-coverage features, the last of which experience a progressive decreasing of marginal increases before reaching a plateau. The above findings facilitate transport practitioners to design sound management schemes for passengers in different categories.