bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothyroidism: clinical presentation, diagnosis, treatment
Authors: Wojtachnio Dominika , Osiejewska Aleksandra , Bartoszewicz Jakub , Grądzik Anna , Nowakowska Izabela , Kudan Małgorzata , Gorajek Anna , Mikut Karolina 
Published: August 2022

Introduction and purpose:
Hypothyroidism is a common disorder of the endocrine system in which the thyroid gland is not able to produce enough of certain thyroid hormones.
Brief description of the state of knowledge:
The prevalence of hypothyroidism is between 1 and 6% and it is more common in women and older adults. Untreated significantly decreases the quality of life and increases mortality. Symptoms of hypothyroidism are nonspecific and may be confused with signs of other clinical conditions. The most common symptoms are chronic tiredness and fatigue, weight gain, cold intolerance, dry skin and hair loss. Serum thyroid-stimulating hormone (TSH) is the primary screening test for thyroid disfunction. Standard treatment for hypothyroidism consists of thyroid hormone replacement called levothyroxine.
Conclusion:
This article reviews basic informations, clinical presentation, diagnosis and treatment of hypothyroidism.
Calendário intercultural: resultado de uma pesquisa-ação com professoras
Authors: Reis Peters Maria José Ambrósio , Lima Marcia Machado 
Published: August 2022

estudo é o resultado de uma pesquisa-ação no período de 2019 a 2021, com professoras do ensino básico da EMEF Prof. Herbert de Alencar na cidade de Porto Velho e teve como objetivo investigar e, compreender os pontos de vista destas participantes sobre as variáveis presentes na socialização e, aprendizado dos estudantes imigrantes no contexto da escola-campo com ênfase nos processos interculturais e étnico-raciais, dialogando com os aspectos da educação étnico racial e a interculturalidade e construir possibilidades de materiais didáticos que pudessem visibilizar, validar, valorizar e circular os saberes dos estudantes bolivianos, haitianos e venezuelanos. As rodas de conversas como um processo de coleta de dados, reuniu informações acerca de conteúdos para serem acrescidos como saberes no currículo da escola campo e também construiu coletivamente um produto educacional denominado Calendário Intercultural.
Adapting a palliative care-focused cancer self- and family management intervention for use in Israel
Authors: Schulman-Green Dena , Feder Shelli L , Collett David , Aaron Eliana M. , Haron Yafa , Eilon Yael , Admi Hanna 
Published: August 2022

Background: In Israel, there is a need to improve quality of life and health outcomes among patients and families facing cancer. Increasing awareness of, literacy about, and availability of palliative care may further this goal. Aims: This study aimed to adapt a palliative care-focused cancer self- and family management intervention developed in the US for use in Israel. Methods: The Managing Cancer Care (MCC) psycho-educational intervention is comprised of Managing Cancer Care: A Personal Guide (MCC-PT©) for patients and Managing Cancer Care: A Caregiver's Guide (MCC-CG©) for family caregivers. Following translation into Hebrew, an expert panel of Israeli nurses edited the MCC tool for cultural relevance. The authors then conducted qualitative interviews with patients with breast cancer and their family caregivers to obtain feedback. Data were analysed using qualitative content analysis. Findings: Following recommendations from Israeli experts in oncology and/or palliative care (n=3), the authors revised intervention content specific to the US healthcare system and culture. Patients' (n=13) and family caregivers' (n=10) reported MCC as attractive (70%, 80%), topically relevant (80%, 70%), and culturally appropriate, but felt that palliative care resources should be more Israel-specific. Conclusion: The MCC tool is acceptable to potential users, warranting further pilot-testing.
The effects of Feijoa sellowiana fruit extract on wound healing in rats: a stereological and molecular study
Authors: Otaghvar Hamidreza Alizadeh , Rezapour-Nasrabad Rafat , Ebrahimzadeh Mohammad Ali , Yaghoubi Mehran , Khalatbary Ali Reza , Nasiry Davood , Raoofi Amir , Rostamzadeh Auob 
Published: August 2022

Objective: The aim of this study was to evaluate the anti-inflammatory and wound-healing potential of Feijoa sellowiana fruit extract using stereological and molecular methods in experimental rat models. Materials: Male Wistar rats were divided into four equal groups: non-treated, vehicle, Feijoa sellowiana fruit extract ointment (5% weight/weight) and the reference drug (madecassol). All animals were treated topically once per day. At the end of the study, wound samples were harvested for histological, stereological, immunohistochemical and molecular assessments to determine the in vivo healing potential and anti-inflammatory activity. A high-performance liquid chromatography (HPLC) analysis was performed for the characterisation of the phenolic acids in the extract. Results: The study included 64 rats in total. Our results showed that the wound closure, volume of new epidermis and dermis, density of fibroblasts and blood vessels, and the deposition of collagen were significantly higher in both extract and madecassol groups compared to the non-treated and vehicle groups, with superior healing in the extract group. The transcript for the transforming growth factor (TGF)-β gene was significantly upregulated in both extract and madecassol groups compared to non-treated and vehicle groups and was highest for the extract group. The density of inflammatory cells and expression levels of the cyclooxygenase (COX)-2 protein and tumour necrosis factor (TNF)-α gene in the extract and madecassol groups, especially in the extract group, were significantly reduced compared to non-treated and vehicle groups. Conclusion: Our results confirm that the Feijoa sellowiana fruit extract is a valuable source of antioxidant and anti-inflammatory activities and can allow for damaged tissue in wounds to recover markedly.
Implementation strategies to increase human papillomavirus vaccination uptake for adolescent girls in sub-Saharan Africa: A scoping review protocol
Authors: Lubeya Mwansa Ketty , Mwanahamuntu Mulindi , Chibwesha Carla , Mukosha Moses , Wamunyima Mercy Monde , Kawonga Mary 
Published: August 2022

Introduction
The human papillomavirus (HPV) is sexually transmitted and infects approximately 75% of sexually active people early in their sexual life. Persistent infection with oncogenic HPV types can lead to malignant conditions such as cervical cancer. In 2006, the World Health Organisation approved the use of an efficacious HPV vaccine for girls aged 9 to 14 to prevent HPV-related conditions. Despite the HPV vaccine being available for about 15 years, dose completion remains as low as 20% in sub-Saharan African (SSA) countries implementing the vaccination program compared to 77% in Australia and New Zealand. A fraught of barriers to implementation exist which prevent adequate coverage. Achieving success for HPV vaccination in real-world settings requires strategies to overcome implementation bottlenecks. Therefore, a better understanding and mapping of the implementation strategies used in sub-Saharan Africa to increase HPV vaccination uptake is critical. This review aims to identify implementation strategies to increase HPV vaccination uptake for adolescent girls in sub-Saharan Africa and provide a basis for policy and future research, including systematic reviews to evaluate effective strategies as we accelerate the elimination of cervical cancer.

Materials and methods
This scoping review will consider studies pertaining to implementation strategies to increase HPV vaccination uptake for adolescent girls in sub-Saharan Africa. Studies targeted at different stakeholders to increase adolescent vaccine uptake will be included. Studies using interventions not fitting the definition of implementation strategies as defined by the refined compilation of implementation strategies from the Expert Recommendations for Implementing Change project will be excluded. MEDLINE (via PubMed), Embase, CINAHL (via EBSCO), Scopus and Google Scholar will be searched. Two independent reviewers will screen titles and abstracts for studies that meet the review’s inclusion criteria, and the full text of eligible studies will be reviewed. Data will be extracted from eligible studies using a structured data charting table developed by this team for inclusion by two independent reviewers and presented in a table and graphical form with a narrative summary.
Safety and performance of surgical adhesives
Authors: Szymanski Lukasz , Gołaszewska Kamila , Małkowska Justyna , Gołębiewska Małgorzata , Kaczyńska Judyta , Gromadka Bartosz , Matak Damian 
Published: August 2022

Background
Tissue adhesives are an alternative to conventional surgical sutures to reduce the time and cost of wound closure and to improve patient comfort. The use of tissue adhesives does not require any subsequent intervention and significantly lowers the volume and rate of blood loss, and reduces the need for transfusions during and after surgery. However, based on their formulation, tissue adhesives’ safety profile and functional properties may differ. Therefore, this study aimed to evaluate the basic safety and performance of NE’X Glue® Surgical Sealant, BioGlue® Surgical Sealant, and PREVELEAKTM Surgical Sealant in vitro.

Methods
The basic safety of commercially available tissue adhesives was evaluated using MEM elution assay according to ISO 10993–5 and endotoxin level according to 85. USP. The in vitro performance was evaluated using lap-shear by tension loading test, burst strength test, degradation, and swelling assays.

Results
NE’X Glue®, BioGlue®, and PREVELEAKTM did not cause cytotoxicity in MEM elution assay. All surgical adhesives are below the general limit of endotoxin contamination of 20 EU/device. NE’X Glue® and BioGlue® showed the highest and comparable strength properties in lap shear and burst strength tests compared to PREVELEAKTM. NE’X Glue® and PREVELEAKTM are characterized by lower degradation potential than BioGlue®. PREVELEAKTM is characterized by the highest swelling when compared to NE’X Glue® and BioGlue®.

Conclusions
NE’X Glue® is most versatile in terms of functional properties while maintaining the same safety profile as BioGlue® and PREVELEAKTM.
An approach in medical diagnosis based on Z-numbers soft set
Authors: Zhao Haiyan , Xiao Qian , Liu Zheng , Wang Yanhong 
Published: August 2022

Background
In the process of medical diagnosis, a large amount of uncertain and inconsistent information is inevitably involved. There have been many fruitful results were investigated for medical diagnosis by utilizing different traditional uncertainty mathematical tools. It is found that there is limited study on measuring reliability of the information involved are rare, moreover, the existed methods cannot give the measuring reliability of every judgment to all symptoms in details.

Objectives
It is quite essential to recognize the impact on the reliability of the fuzzy information provided under inadequate experience, lack of knowledge and so on. In this paper, the notion of the Z-numbers soft set is proposed to handle the reliability of every judgment to all symptoms in details. The study in this paper is an interdisciplinary approach towards rapid and efficient medical diagnosis.

Methods
An approach based on Z-numbers soft set (ZnSS)to medical diagnosis has been developed and is used to estimate whether two patterns or images are identical or approximately. The notion of Z-numbers soft set is proposed by combing the theory of soft set and Z-numbers theory. The basic properties of subset, equal, intersection, union and complement operations on the Z-numbers soft sets are defined and the similarity measure of two Z-numbers soft sets are also discussed in this paper.

Results
An illustrative example similar to existing studies is showed to verify the effectiveness and feasibility, which can highlight the proposed method and demonstrate the solution characteristics.

Conclusion
Diagnosing diseases by uncertainty symptoms is not a direct and simple task at all. The approach based on ZnSS presented in this paper can not only measure reliability of the information involved, but also give the measuring reliability of every judgment to all symptoms in details.
Mitigation of noise-induced bias of PET radiomic features
Authors: Somasundaram Ananthi , Vállez García David , Pfaehler Elisabeth , van Sluis Joyce , Dierckx Rudi A. J. O. , de Vries Elisabeth G. E. , Boellaard Ronald 
Published: August 2022

Introduction
One major challenge in PET radiomics is its sensitivity to noise. Low signal-to-noise ratio (SNR) affects not only the precision but also the accuracy of quantitative metrics extracted from the images resulting in noise-induced bias. This phantom study aims to identify the radiomic features that are robust to noise in terms of precision and accuracy and to explore some methods that might help to correct noise-induced bias.

Methods
A phantom containing three 18F-FDG filled 3D printed inserts, reflecting heterogeneous tracer uptake and realistic tumor shapes, was used in the study. The three different phantom inserts were filled and scanned with three different tumor-to-background ratios, simulating a total of nine different tumors. From the 40-minute list-mode data, ten frames each for 5 s, 10 s, 30 s, and 120 s frame duration were reconstructed to generate images with different noise levels. Under these noise conditions, the precision and accuracy of the radiomic features were analyzed using intraclass correlation coefficient (ICC) and similarity distance metric (SDM) respectively. Based on the ICC and SDM values, the radiomic features were categorized into four groups: poor, moderate, good, and excellent precision and accuracy. A “difference image” created by subtracting two statistically equivalent replicate images was used to develop a model to correct the noise-induced bias. Several regression methods (e.g., linear, exponential, sigmoid, and power-law) were tested. The best fitting model was chosen based on Akaike information criteria.

Results
Several radiomic features derived from low SNR images have high repeatability, with 68% of radiomic features having ICC ≥ 0.9 for images with a frame duration of 5 s. However, most features show a systematic bias that correlates with the increase in noise level. Out of 143 features with noise-induced bias, the SDM values were improved based on a regression model (53 features to excellent and 67 to good) indicating that the noise-induced bias of these features can be, at least partially, corrected.

Conclusion
To have a predictive value, radiomic features should reflect tumor characteristics and be minimally affected by noise. The present study has shown that it is possible to correct for noise-induced bias, at least in a subset of the features, using a regression model based on the local image noise estimates.
Development and validation of a prediction algorithm to identify birth in countries with high tuberculosis incidence in two large California health systems
Authors: Fischer Heidi , Qian Lei , Skarbinski Jacek , Bruxvoort Katia J. , Wei Rong , Li Kris , Amsden Laura B. , Wood Mariah S. , Eaton Abigail , Spence Brigitte C. , Shaw Sally F. , Tartof Sara Y. 
Published: August 2022

Objective
Though targeted testing for latent tuberculosis infection (“LTBI”) for persons born in countries with high tuberculosis incidence (“HTBIC”) is recommended in health care settings, this information is not routinely recorded in the electronic health record (“EHR”). We develop and validate a prediction model for birth in a HTBIC using EHR data.

Materials and methods
In a cohort of patients within Kaiser Permanente Southern California (“KPSC”) and Kaiser Permanent Northern California (“KPNC”) between January 1, 2008 and December 31, 2019, KPSC was used as the development dataset and KPNC was used for external validation using logistic regression. Model performance was evaluated using area under the receiver operator curve (“AUCROC”) and area under the precision and recall curve (“AUPRC”). We explored various cut-points to improve screening for LTBI.

Results
KPSC had 73% and KPNC had 54% of patients missing country-of-birth information in the EHR, leaving 2,036,400 and 2,880,570 patients with EHR-documented country-of-birth at KPSC and KPNC, respectively. The final model had an AUCROC of 0.85 and 0.87 on internal and external validation datasets, respectively. It had an AUPRC of 0.69 and 0.64 (compared to a baseline HTBIC-birth prevalence of 0.24 at KPSC and 0.19 at KPNC) on internal and external validation datasets, respectively. The cut-points explored resulted in a number needed to screen from 7.1–8.5 persons/positive LTBI diagnosis, compared to 4.2 and 16.8 persons/positive LTBI diagnosis from EHR-documented birth in a HTBIC and current screening criteria, respectively.

Discussion
Using logistic regression with EHR data, we developed a simple yet useful model to predict birth in a HTBIC which decreased the number needed to screen compared to current LTBI screening criteria.

Conclusion
Our model improves the ability to screen for LTBI in health care settings based on birth in a HTBIC.
Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2/hydroxyapatite compared to deproteinized bovine bone
Authors: Han Jeong Joon , Moon Ji Eun , Lee Eun-Hyuk , Yang Hoon Joo , Hwang Soon Jung 
Published: August 2022

Objectives
This study aimed to evaluate the clinical and radiographic outcomes of early implant placement and functional loading in maxillary sinus floor augmentation (MSFA) using recombinant human bone morphogenetic protein 2/hydroxyapatite (rhBMP-2/HA) and to compare these outcomes with those of the conventional protocol in MSFA using deproteinized bovine bone (DBB).

Materials and methods
The rhBMP-2/HA and DBB groups consisted of 14 and 13 patients who underwent MSFA with BMP and DBB, respectively. After placement of 22 implants and 21 implants in the rhBMP-2/HA and DBB groups, respectively, abutment connections were performed 3 months after implant placement for the rhBMP-2/HA group and 6 months after implant placement for the DBB group. Changes in grafted sinus height (GSH), marginal bone loss (MBL), and implant stability were evaluated up to one year after functional loading.

Results
Survival rates for the rhBMP-2/HA and DBB groups after one year of functional loading were 90.9% and 90.5%, respectively. Both groups exhibited no significant time-course changes in GSH until one year of functional loading (rhBMP-2/HA, p = 0.124; DBB, p = 0.075). Although significant MBL occurred after one year of functional loading for both groups (rhBMP-2/HA, p < 0.001; DBB, p < 0.001), there were no significant differences in time-course changes in MBL between the two groups (p = 0.450). The mean implant stability quotient values in the rhBMP-2/HA and DBB groups were 75.3 and 75.4 after one year of functional loading, respectively, and there were no significant differences between the two groups (p = 0.557).

Conclusions
MSFA using rhBMP-2/HA allowed implant rehabilitation with early implant placement and functional loading and led to a comparable survival rate and implant stability after 1 year of functional loading with acceptable MBL and stable maintenance of GSH compared to the MSFA using DBB with 6 months of healing after implant placement.
Pediatric Clinical Classification System for use in Canadian inpatient settings
Authors: Gill Peter J. , Thavam Thaksha , Anwar Mohammed Rashidul , Zhu Jingqin , To Teresa , Mahant Sanjay ,   on behalf of the Canadian Paediatric Inpatient Research Network (PIRN)
Published: August 2022

Background
A classification system that categorizes International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) diagnosis codes into clinically meaningful categories is important for pediatric clinical and health services research using administrative data. While a Pediatric Clinical Classification System (PECCS) is available for the United States ICD-10 system (i.e, ICD-10-CM), differences in the ICD-10 system between countries limits PECCS use in Canada.

Objective
To translate PECCS from ICD-10-CM to ICD-10-CA for use in Canada (PECCS-CA), and examine the utility of PECCS-CA in administrative data of pediatric hospital encounters in Ontario, Canada.

Methods
PECCS was translated by mapping each ICD-10-CA code to its corresponding ICD-10-CM code, based on code description and alphanumeric code, using automated functions in Microsoft Excel. All unmatched ICD-10-CA codes were manually matched to an ICD-10-CM code. The ICD-10-CA codes were mapped to a PECCS category based on the placement of the corresponding ICD-10-CM code. Finally, in this cross-sectional study, the utility of PECCS-CA was examined in pediatric hospital encounters in children <18 years of age with an inpatient or same day surgery encounter, between April 1, 2014 to March 31, 2019 in Ontario.

Results
In total, 16,992 ICD-10-CA diagnosis codes were mapped to 781 mutually exclusive condition categories that included pediatric specific conditions and treatments in PECCS-CA. From the 781 categories, 777 (99.5%) were derived from the original PECCS, 3 (0.4%) from merging the original PECCS categories, and 1 (0.1%) was newly developed. The PECCS-CA was applied to health administrative data of 911,732 hospital encounters in children. The most prevalent condition in children was low birth weight (n = 54,100 encounters).

Conclusion
The PECCS-CA is an open-source classification system which maps ICD-10-CA codes into 781 clinically important pediatric categories. The PECCS-CA can be used for pediatric health services and outcomes research in Canada.
Functional Lumen Imaging Probe Panometry Helps Identify Clinically Relevant Esophagogastric Junction Outflow Obstruction per Chicago Classification v4.0
Authors: Carlson Dustin A. , Schauer Jacob M. , Kou Wenjun , Kahrilas Peter J. , Pandolfino John E. 
Published: August 2022

INTRODUCTION:
Esophagogastric junction (EGJ) outflow obstruction (EGJOO) per Chicago Classification v4.0 (CCv4.0) represents a high-resolution manometry (HRM) diagnosis with uncertain clinical significance. This study aimed to evaluate functional lumen imaging probe (FLIP) panometry among patients with EGJOO on HRM/CCv4.0 to assess clinical/manometric associations and treatment outcomes.

METHODS:
An observational cohort study was performed on patients who completed FLIP during endoscopy and had an HRM/CCv4.0 diagnosis of EGJOO, i.e., HRM-EGJOO (inconclusive). Abnormal FLIP panometry motility classifications were applied to identify FLIP-confirmed conclusive EGJOO. Rapid drink challenge on HRM and timed barium esophagram were also assessed. Clinical management plan was determined by treating physicians and assessed through chart review. Clinical outcome was defined using the Eckardt score (ES) during follow-up evaluation: ES < 3 was considered a good outcome.

RESULTS:
Of 139 adult patients with manometric EGJOO (inconclusive per CCv4.0), a treatment outcome ES was obtained in 55 after achalasia-type treatment (i.e., pneumatic dilation, peroral endoscopic myotomy, laparoscopic Heller myotomy, or botulinum toxin injection) and 36 patients after other nonachalasia-type treatment. Among patients with conclusive EGJOO by HRM-FLIP complementary impression, 77% (33/43) had a good outcome after achalasia-type treatment, whereas 0% (0/12) of patients had a good outcome after nonachalasia-type treatment. Of patients with normal EGJ opening on FLIP, one-third of patients treated with achalasia-type treatment had a good outcome, while 9 of the 10 treated conservatively had a good outcome.

DISCUSSION:
FLIP panometry provides a useful complement to clarify the clinical significance of an HRM/CCv4.0 EGJOO diagnosis and help direct management decisions.