bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of toxic nephropathy development during antibiotic therapy
Authors: Kazakov R. E. , Gorodetskaya G. I. , Archvadze R. V. , Zavtonev A. V. , Danilov A. V. , Fetlam D. L. , Ishalev D. A. , Berdnikova N. G. , Demchenkova E. Yu. 
Published: October 2022

Scientist relevance. Antibacterials can have nephrotoxic effects because medicinal products of this class are primarily excreted by the kidneys.Aim. The study aimed to analyse literature data on the mechanisms, risk factors and specific features of toxic nephropathy development during antibiotic therapy.Discussion. The article considers mechanisms of development of acute interstitial nephritis, acute tubular necrosis, crystal deposits in the tubules, proximal or distal tubulopathy with electrolyte abnormalities during the use of antibiotics. Nephrotoxicity was shown to be most often associated with the use of aminoglycosides, beta-lactams, and vancomycin. The authors analysed the dependence of nephrotoxicity on antibacterial agent lipophilicity and drug–drug interactions. The main risk factors for developing nephropathy are older age; male sex; black race; hypovolaemia; arterial hypotension; angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, non-steroidal anti-inflammatory drugs or their combinations; and individual genetic characteristics. Nephrotoxicity is associated with genetic characteristics of the systems responsible for metabolism and excretion of antibacterial products: cytochrome P450 isoenzymes, P-glycoprotein, multidrug resistance protein (MRP), multidrug and toxin extrusion (MATE), breast cancer resistance protein (BCRP), and organic anion transporters. Severe generalised infections change pharmacokinetic parameters of antibacterial products. This should be taken into account when prescribing the hydrophilic antibiotics that are excreted by tubular secretion and reabsorbed in the renal tubules.Conclusions. The study demonstrated the effectiveness of the method comprising a combination of dose adjustment based on therapeutic drug monitoring results and renal function monitoring for improving the safety of antibiotic therapy.
Hypoandrogenism as a manifestation of comorbid pathology in the violation of natural fertility of women of reproductive age
Authors: Semeniuk L. M. , Yuzvenko T. Y. , Ventskivska I. B. , Chernukha L. S. 
Published: October 2022

Objective — optimization of pre‑gravid preparation of patients with hypoandrogenism and history of early pregnancy losses.
Materials and methods. Examinations at the pre‑pregnant stage involved 69 women with a history of early pregnancy loss and hypoandrogenism (group I). The control group consisted of 30 healthy women (group II). Hormonal examination was performed in the first phase of the menstrual cycle (5 — 7 days) using the Vitros automated system of the Jonson & Jonson company, and biochemical examination was performed on a Hitachi 912 analyzer using standard Roche (Switzerland) kits.
Results. For the women of the main group, the signs of functional hypogonadism and violation of ovarian steroidogenesis were characteristic with the following manifestations: decrease in the sex steroids’ level, which directly and significantly correlated with the indicators of gonadotropic hormones: luteinizing hormone (LH) and estradiol r = 0.67; follicle‑stimulating hormone (FSH) and estradiol r = 0.64; LH and dihydroepiandrosterone sulfate (DGEA‑C) r = 0.33 (p = 0.02), FSH and DGEA‑C r = 0.27 (p = 0.03). This group of women showed signs of dyslipidemia — an increase in the cholesterol index compared to the control: 5.43 [5.04; 5.82] versus 4.04 [3.87; 4.21]mmol/l in the control (p < 0.05), a tendency towards an increase in the level of low‑density lipoproteins 3.24 mmol/l [2.9; 3.59] and, respectively, 2.12 mmol/l [1.93; 2.32] in the control group (p = 0.15). There was a decrease in high‑density lipoproteins of 1.42 mmol/l [1.12; 1.71] in women of the 1st group in comparison with the indicator of the control group of 2.30 mmol/l [1.70; 2.89] (p = 0.58). The presence of inverse significant relationships of average strength between the concentrations of estradiol and cholesterol (r = – 0.46; p < 0.001), estradiol and triglycerides (r = –0.55; p < 0.0001), testosterone and cholesterol (r = –0.44; p < 0.006) has been revealed.
Conclusions. Women of reproductive age with a history of hypoandrogynism and reproductive losses have functional hypogonadism and a tendency to dyslipidemia. The standard scheme of pre‑gravid preparation of such patients should include gastroenterologist’s consultation and personalized therapy of identified disorders for early prevention of dysmetabolic diseases at the onset of pregnancy.
Diabetic gastroparesis: current data on epidemiology, pathophysiology, diagnosis and treatment. Review
Authors: Tkach S. M. , Pankiv V. I. , Dogotar V. B. , Yuzvenko V. S. 
Published: October 2022

The analysis has been performed for the current data on the epidemiology, pathophysiology, diagnosis and treatment of diabetic gastroparesis.
The search was conducted in PubMed and Medline databases. The following keywords were used: «diabetic gastroparesis», «complications of diabetes», «risk factors». Articles published in peer‑reviewed publications were taken into account.
Diabetic gastroparesis is a serious complication of diabetes, which leads to its poor control, worsens the quality of life, increases frequency of comorbidities and mortality. This complication is characterized by abdominal distension, nausea, vomiting, weight loss and early satiety, but should be confirmed/diagnosed by scintigraphy or 13C‑octanoic breath test. Though there is no evidence that diabetic gastroparesis significantly increases mortality, this complication impairs all aspects of life. Gastroparesis carries a significant burden on patients, with a negative correlation between the severity of symptoms and their quality of life; the disease also has a significant negative impact on the health care system, in particular, due to increase in the number of hospitalizations and associated direct and indirect economic consequences. First‑line treatment for diabetic gastroparesis includes dietary modification, glycemic control, and fluid and electrolyte replacement. Those patients who have persistent symptoms may require pharmacological or even surgical treatment. Among pharmaceuticals, prokinetics are most often used, in particular metoclopramide, domperidone or erythromycin. Antiemetics, in particular phenothiazines and antihistamines, are also prescribed to reduce symptoms. Newer drugs under investigation include ghrelin agonists such as relamorelin, as well as serotonin receptor agonists such as prucalopride and velusetrag. In refractory cases, various options for surgical treatment or electrical stimulation of the stomach are recommended.
Relationship of sexual quality of life and mental well-being in undergraduate women in a Canadian university
Authors: Oveisi Niki , Khan Zeba , Brotto Lori A. 
Published: October 2022

As young women transition from adolescence to adulthood, they begin to explore their sexual identities and sexual relationships. The current literature supports the relationship between sexual quality of life (QOL) and mental well-being. However, this relationship has not yet been replicated in undergraduate women. In order to address this gap, the authors assessed the correlation between sexual QOL and mental well-being among a sample of women undergraduate students in Canada. The study design was cross-sectional in nature, and demographic information was collected, along with the completion of validated measures of sexual QOL and mental well-being. A total of 157 individuals participated. After removing those who did not meet inclusion criteria and those with > 90% incomplete responses, 124 valid survey responses remained for analysis. A hierarchical multivariable linear regression was conducted while controlling for age, sexual orientation, exercise, history of nonconsensual sexual contact, household income, and self-perceived health status. Every one-unit increase in sexual QOL was associated with a 0.35 increase in mental well-being (95% CI 0.105–0.428, p = .002). A history of unwanted or nonconsensual sexual activity had a significant negative correlation with mental well-being ( p = .027). The authors’ findings suggest a significant relationship between sexual QOL and mental well-being. There is a strong opportunity for universities to bolster the support services available to students, with a required focus on women with a history of nonconsensual sexual contact.
5-ALA fluorescence–guided resection of a recurrent anaplastic pleomorphic xanthoastrocytoma: illustrative case
Authors: Leavitt Lydia A. , Muñoz William , Jones Pamela S. 
Published: October 2022

BACKGROUND
5-aminolevulinic acid (5-ALA)–induced fluorescence of neoplastic tissue is known to occur in a number of high-grade gliomas. This fluorescence helps surgeons maximize safe resection by distinguishing previously indiscernible neoplastic tissue from brain parenchyma. Still, the effectiveness of 5-ALA has not been fully explored for all central nervous system tumors. Consequently, the full spectrum of tumors that would benefit from fluorescence-guided surgery using 5-ALA is unknown.

OBSERVATIONS
This report describes successfully utilizing 5-ALA to achieve complete resection of a recurrent anaplastic pleomorphic xanthoastrocytoma (APXA).

LESSONS
APXA tumor cells accumulate sufficient amounts of 5-ALA and its fluorescent metabolite to produce visible intraoperative fluorescence. However, further investigation is needed to determine if 5-ALA fluorescent labeling routinely occurs in patients with APXAs.
The value of high-resolution imaging in an occult peroneal intraneural ganglion cyst: illustrative case
Authors: Lenartowicz Karina A. , Amrami Kimberly K. , Strakowski Jeffrey A. , Howe B. Matthew , Spinner Robert J. 
Published: October 2022

BACKGROUND
Foot drop is a common complaint with a broad differential diagnosis making imaging a key part of the diagnostic workup. The authors present a patient with an occult peroneal intraneural ganglion cyst who underwent imaging with high-frequency ultrasound (US) and high-resolution magnetic resonance imaging (MRI) to highlight the role of such techniques in cases of peroneal neuropathy.

OBSERVATIONS
Intraneural ganglion cysts are emerging as a common cause of common peroneal neuropathy. Imaging with US and MRI is a valuable tool used to illustrate the pertinent anatomy and identify the articular branch joint connection and cyst as part of the surgical planning and definitive management.

LESSONS
Intraneural ganglion cysts can be small or nearly invisible and failure to appreciate the intraneural cyst can lead to symptom or cyst persistence or recurrence. High-resolution modalities can be useful in the diagnosis and surgical planning of difficult cases.
Factors Affecting Farmers’ Adoption of Sustainable Land Management Practices in Vietnam
Authors: Dung Nguyen Mau 
Published: October 2022

This study aimed to identify the factors affecting farmers’ adoption of sustainable land management (SLM) practices to combat land degradation in Vietnam. Based on the survey data from 826 farmers in three representative regions, the study showed that the SLM model and SLM adoption rate were quite varied due to differences of natural and socio-economic conditions. The results of logistic regression showed that household income and access to loans had positive impacts on SLM adoption with statistical significance in all the regions surveyed. More extension visits in the upland and coastal regions, and more agricultural laborers in farm households in the coastal and Mekong delta regions were found to increase the probability of SLM adoption. Meanwhile, the number of plots and number of members in households were found to have negative impacts on adoption. Providing training courses for farmers, building SLM demonstrations, and providing financial support for farmers through credit programs should be enhanced for better SLM adoption in farm households.
POLITICAL DISCOURSE
Authors: ALMOHADAWI MOHAMMED AKIF , ALI HISHAM ALI HUSSAIN 
Published: October 2022

Проблема политического дискурса появилась как реакция на необходимость обобщения, или как попытка поиска общих точек в огромном разнообразии исследования политики. Эту задачу ставил перед собой Фуко, когда писал «Археологию знания», для дисциплин «чьи границы очень размыты, а содержание крайне неопределенно - в истории идеи, науки, мысли или познания» .
Политический дискурс, кроме видимых на первый взгляд положительных результатов для исследования политических явлений - возможности взаимного использования различных методологических подходов, максимального привлечения исследований смежных наук (психологии, социологии, лингвистики), предоставление возможности определения объекта исследования, поставил также много вопросов, требующих решения: в частности, проблемы выведения из-под обвинений чрезмерной ангажированности в лингвистических исследованиях, проблемы носителей политичности, проблемы структуры и формы.
الحماية القانونية للمرأة من العنف
Authors: Abdullah Muhammad Qasim , Alawi Moh Araq 
Published: October 2022

يعد العنف من أولى مظاهر السلوك التي عرفتها المجتمعات البشرية. لكنه عرف ارتفاعا كبيرا خلال العقود الأخيرة، ولا يكاد يخلو مجتمع من بعض أشكاله التي عرفتها المجتمعات منذ زمن قديم، إلا أن بعض أسبابه مرتبط ببعض خصائص المجتمع الحديث. خصوصا تلك التي تبدو أنها تعبير عن الضغوطات و مشاعر الإحباط و القهر. وتعد حماية المرأة من العنف الحجر الاساس الذي يمكن البناء عليه لوقايتها من التمييز والاضطهاد والنهوض بواقعها تمهيداً من الاسهام الفاعل والبناء في عملية التنمية، اذ ان المرأة المهمشة والمعنفة والمنتهكة حقوقها تشكل حجر عثرة ضد اي محاولة تغيير او تطوير في الدولة.
وقد توصل البحث إلى اهم النتائج الأتية:

ان عدم وجود القوانين التي تحمي المرأة من العنف، هي أحد العوامل المؤدية إلى زيادة العنف ضدها.
لا يوجد دعم نفسي واجتماعي وقانوني للمرأة المعنفة.
ان معرفة المرأة بحقوقها يقلل من العنف الموجه نحوها.
تعيش النساء في العراق في خوف من العنف مع اشتداد حدة النزاع وتصاعد الاضطراب الأمني.
هناك تغاضي عن منح المرأة العديد من حقوقها وتامين حماية قانونية لها.
Immune response in suckling mice fed PBMCs harvested from adult mice and pulsed with Prevnar13: a pilot study
Authors: Steiner Don , Gosselin Edmund , Nalin David 
Published: October 2022

Five-day-old mouse pups were fed either Prevnar 13 alone or peripheral blood mononuclear cells (PBMCs) isolated from adult donors and pulsed _ex vivo_ with Prevnar-13. Mice vaccinated with Prevnar-13 or with vaccine-pulsed PBMCs displayed a positive serum IgM response greater than that of mice treated with mock-pulsed PBMCs, though the response of Prevnar-13-treated vs. Prevnar 13-pulsed PMBC-treated groups was not significantly different. However, neither group was protected against lethal infectious challenge. We conclude that it is possible to elicit a neonatal immunological response after vaccine or vaccine-pulsed PBMCs administered via the oral route, but a single dose is insufficient to protect against subsequent infection. Further studies can confirm whether a booster dose may improve protective efficacy and may reveal a difference between vaccine-pulsed PBMC treatment and vaccine alone that is not apparent after a single dose.
New Potentially Probiotic Strains Isolated from Humans – Comparison of Properties with Strains from Probiotic Products and ATCC Collection
Authors: Zawistowska-Rojek Anna , Kociszewska Agnieszka , Zaręba Tomasz , Tyski Stefan 
Published: October 2022

Abstract
Lactic acid bacteria are used in various types of probiotic products. Due to the constantly growing probiotics market, new strains with pro-health properties are sought. The present study compared 39 strains of Lactobacillus, Lacticaseibacillus, and Lactiplantibacillus, isolated from probiotic products and healthy people. The current research aimed to search for new, potentially probiotic strains. For this purpose the relationship between Lactobacillaceae strains was carried out; moreover, the basic properties of probiotic microorganisms, such as survival at low pH and bile salt environment, antibiotic susceptibility, aggregation and antagonism were estimated. The properties of these isolates were also compared with the properties of probiotic strains from the ATCC collection. In comparing the genetic relationship (PFGE method) between the tested isolates, it was observed that some of them show a high degree of similarity. All tested strains tolerated an environment with a pH value of 3.0, and the addition of 0.3% bile salt; showed auto-aggregation properties and displayed antagonism against pathogenic microorganisms. In the present study, the bacteria were susceptible to tetracycline, chloramphenicol and ampicillin; the resistance to vancomycin
depended on the bacteria type. All the properties were strain-depended. Most of the tested strains had properties comparable to the reference strains. Three L. acidophilus strains isolated from cervical swabs seem to be promising candidates for probiotic strains.
Opportunistic Candida Infections in Critical COVID-19 Patients
Authors: Altinkaya Çavuş Mıne , Sav Hafıze 
Published: October 2022

Abstract
The frequency of opportunistic fungal infections in critically ill patients whose intensive care unit stays are prolonged due to coronavirus disease 2019 (COVID-19) is higher than in the period before COVID-19. We planned this study to improve the management of Candida infections by defining the Candida species, the etiology of infections caused by Candida species, and the antifungal susceptibility of the species. This retrospective study included patients older than 18 hospitalized in the intensive care unit (ICU) with a definitive diagnosis of COVID-19 for seven months (from March 2021 to September 2021). All study data that we recorded in a standard study form were analyzed with TURCOSA (Turcosa Analytics Ltd. Co., Turkey, www.turcosa.com.tr) statistical software. The patients were evaluated in four groups as group 1 (candidemia patients, n = 78), group 2 (candiduria patients, n = 189), group 3 (control patients, n = 57), and group 4 (patients with candidemia in urine cultures taken before Candida was detected in blood culture, n = 42). Candida species were identified using both conventional and VITEK® 2 (BioMérieux, France) methods. The antifungal susceptibility of fungi was determined using the E test method. Of the 5,583 COVID-19 patients followed during the study period, 78 developed candidemia, and 189 developed candiduria. The incidence of candidemia (per 1,000 admissions) was determined to be 1.6. As a result of statistical analysis, we found that Candida albicans was the dominant strain in candidemia and candiduria, and there was no antifungal resistance except for naturally resistant strains. Candida strains grown in blood and urine were the same in 40 of 42 patients. Mortality was 69.2% for group 1, 60.4% for group 2, and 57.8% for group 3. Antifungals were used in 34 (43.5%) patients from group 1, and 95 (50.2%) from group 2. In the candidemia group without antifungal use, mortality was quite high (77.2%). Antifungal use reduced mortality in the group 2 (p < 0.05). Length of ICU stays, comorbidity, broad-spectrum antibiotics, and corticosteroids are independent risk factors for candidemia in critically ill COVID-19 patients. Our study contributes to the knowledge of risk factors for developing COVID-19-related candida infections. The effect of candiduria on the development of candidemia in critically ill COVID-19 patients should be supported by new studies.
Indoor Positioning and Navigating System Application Using Wi-Fi with Fingerprinting Method and Weighted K-Nearest Neighbor Algorithm
Authors: Hadi Yulianto Arya Putra , Zakaria M. Nanak , Yulianto Ahmad WIlda 
Published: October 2022

The need for accurate indoor location determination, object tracking, digital maps and indoor travel routes is increasing along with the construction of buildings that have complex and spacious layouts. The current Global Positioning System navigation system is only effective for outdoor use. However, when used indoors it becomes inaccurate due to factors such as signal attenuation and multipath caused by wall obstructions in the building. This study designed an application of Indoor Positioning and Navigating System Using Wi-Fi with Fingerprinting method and Weighted K-Nearest Neighbor algorithm. In the design process, it is necessary to create a fingerprinting database by considering the number of Access points and environmental conditions. Based on the results of the study, the location results of the application show that from floors 1,2, and 3. Floor 1 has a room accuracy result of 89% and a point accuracy of 86% with an average deviation of 1.42 px or 0.9 m, floor 2 has room accuracy results. of 65% and a point accuracy of 70% with an average deviation of 2.43 px or 1.7 m, and the 3rd floor has a room accuracy of 86% and a point accuracy of 68% with an average deviation of 2.27 or 1.5 m. Based on the data above, this application is proven to be able to detect the position of someone in the room with a success percentage on the 1st floor by 90%, the 2nd floor by 55%, and the 3rd floor by 80%.
Endoscopic treatment of pancreaticopleural fistulas
Authors: Jagielski Mateusz , Piątkowski Jacek , Jackowski Marek 
Published: October 2022

IntroductionPancreaticopleural fistula (PPF) is a serious complication of acute and chronic pancreatitis.ObjectiveTo evaluate the effectiveness of various endoscopic techniques for the treatment of patients with PPFs.MethodologyProspective analysis of the results of endoscopic treatment of 22 patients with PPF due to pancreatitis was conducted at the Department of General, Gastroenterological, and Oncological Surgery, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, between 2018 and 2021.ResultsPPF was diagnosed in 22 patients (21 men and 1 woman; mean age 49.52 [30–67] years) with pancreatitis. In 19/22 (86.36%) patients, PPF communicated with the left pleural cavity and in 3/22 (13.64%) patients with the right pleural cavity. Chronic pancreatitis was diagnosed in 14/22 (63.64%) patients. Symptomatic pancreatic fluid collections were found in 15/22 (68.18%) patients with PPF (pancreatic pseudocyst in 11 and walled-off pancreatic necrosis in four patients). Endoscopic retrograde cholangiopancreatography was performed in 21/22 (95.45%) patients, confirming the diagnosis of PPF. All 21 patients underwent endoscopic sphincterotomy with prosthesis implantation in the main pancreatic duct (passive transpapillary drainage). In 1/22 (4.55%) patients, active transmural/transgastric drainage of the PPF was necessary due to inflammatory infiltration of the peripapillary region, precluding endoscopic pancreatography. Endoscopic transmural drainage was performed in all the 15 patients with pancreatic fluid collection. Clinical success was achieved in 21/22 (95.45%) patients. The mean total time of endotherapy was 191 (range 88–712) days. Long-term success of endoscopic treatment of PPFs during one year follow-up period was achieved in 19/22 (86.36%) patients.ConclusionsEndoscopic treatment is effective for managing post-inflammatory PPFs. The preferred treatment method is passive transpapillary drainage (prosthesis of the main pancreatic duct). If transpapillary drainage is not feasible, transmural drainage of the PPF remains the preferred method. Endoscopic transmural drainage leads to closure of the fistula canal in patients with pancreatic fluid collection complicated by PPF.