bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marital Status and Gender Differences as Key Determinants of COVID-19 Impact on Wellbeing, Job Satisfaction and Resilience in Health Care Workers and Staff Working in Academia in the UK During the First Wave of the Pandemic
Authors: Peng Junjie , Wu Wing Han , Doolan Georgia , Choudhury Naila , Mehta Puja , Khatun Ayesha , Hennelly Laura , Henty Julian , Jury Elizabeth C. , Liao Lih-Mei , Ciurtin Coziana 
Published: June 2022

BackgroundThe COVID-19 pandemic is an unprecedented global public health crisis that continues to exert immense pressure on healthcare and related professional staff and services. The impact on staff wellbeing is likely to be influenced by a combination of modifiable and non-modifiable factors.ObjectivesThe aim of this study is to evaluate the effect of the COVID-19 pandemic on the self-reported wellbeing, resilience, and job satisfaction of National Health Service (NHS) and university staff working in the field of healthcare and medical research.MethodsWe conducted a cross sectional survey of NHS and UK university staff throughout the COVID-19 pandemic between May-November 2020. The anonymous and voluntary survey was disseminated through social media platforms, and via e-mail to members of professional and medical bodies. The data was analyzed using descriptive and regression (R) statistics.ResultsThe enjoyment of work and satisfaction outside of work was significantly negatively impacted by the COVID-19 pandemic for all of staff groups independent of other variables. Furthermore, married women reporting significantly lower wellbeing than married men (P = 0.028). Additionally, the wellbeing of single females was significantly lower than both married women and men (P = 0.017 and P &lt; 0.0001, respectively). Gender differences were also found in satisfaction outside of work, with women reporting higher satisfaction than men before the COVID-19 pandemic (P = 0.0002).ConclusionOur study confirms that the enjoyment of work and general satisfaction of staff members has been significantly affected by the first wave of the COVID-19 pandemic. Interestingly, being married appears to be a protective factor for wellbeing and resilience but the effect may be reversed for life satisfaction outside work. Our survey highlights the critical need for further research to examine gender differences using a wider range of methods.
Wide-Awake Local Anesthesia With no Tourniquet Versus General Anesthesia for the Plating of Distal Radius Fracture: A Systematic Review and Meta-Analysis
Authors: Tu Ting-Yu , Hsu Chih-Yang , Lin Pei-Chin , Chen Chun-Yu 
Published: June 2022

BackgroundDistal radius fractures are treated using open reduction and internal fixation and using general anesthesia (GA) or regional blocks. A new technique, wide-awake local anesthesia with no tourniquet (WALANT), allows this operation to be conducted in nonsedated patients without the use of tourniquets.ObjectiveWe analyzed whether WALANT yields better outcomes than GA in the treatment of patients with distal radius fractures.Evidence ReviewWe searched the PubMed, Cochrane Library, Embase, and Scopus databases for cases of distal radius fractures treated using WALANT or GA. The outcomes of interest were duration of preparation for surgery, duration of surgery, blood loss, and length of postoperative hospitalization; visual analog scale (VAS), Mayo wrist score, and Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire score on postoperative day 1; range of motion (ROM); time until bone union; and complication rate.FindingsWe systematically reviewed 4 studies with a total of 263 patients (128 with WALANT and 135 with GA). In comparison with GA, WALANT required less time for preparation for surgery, shorter postoperative hospitalization, and lower postoperative day 1 VAS scores; however, blood loss was greater. Functional outcomes (ROM, QuickDASH score, and Mayo wrist score), complication rates, and times until union did not differ considerably between the two methods.ConclusionThe included studies demonstrated that durations of preparation for surgery and postoperative hospitalization were shorter and pain on postoperative day 1 was less severe with WALANT than with GA. Although blood loss in surgery was greater with WALANT, this technique is a novel and promising alternative to GA.
Association of a Modified Blumgart Anastomosis With the Incidence of Pancreatic Fistula and Operation Time After Laparoscopic Pancreatoduodenectomy: A Cohort Study
Authors: He Yong-Gang , Yang Xiao-Min , Peng Xue-Hui , Li Jing , Huang Wen , Jian Gui-Cang , Wu Jing , Tang Yi-Chen , Wang Liang , Huang Xiao-Bing 
Published: June 2022

ObjectiveTo explore the association between a modified Blumgart anastomosis technique and the operative time and surgical complications.MethodsThis is a retrospective cohort study that analyzed the data of patients who underwent laparoscopic pancreaticoduodenectomy from January 2015 to March 2021. The primary outcome was to explore the association between the modified Blumgart anastomosis technique and operative time.ResultsA total of 282 patients were enrolled. There were 177 cases of pancreatic duct-to-mucosa anastomosis in the traditional surgery group, and 105 cases of the modified three-step Blumgart anastomosis in the modified group. There were no statistically significant differences in the general and intraoperative characteristics found between the two groups (P &gt; 0.05). The surgical method was an independent predictor of operative time. Overall complications postsurgery were less common in the modified group than in the traditional group. The incidence of postoperative pancreatic fistula was higher in the traditional group than in the modified group (45 cases (25.4%) and 11 cases (10.5%), respectively). Fourteen cases (7.9%) in the traditional group and four case (3.8%) in the modified group had postoperative pancreatic fistula of grades B + C. The two groups had statistically significant differences (P &lt; 0.05). The results of the linear regression showed that the type of surgical method was associated with operation time (95% CI, −73.074 to −23.941, β: −0.438, P &lt; 0.001).ConclusionThis modified three-step Blumgart pancreaticojejunostomy was associated with the operation time.
Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA
Authors: Heintz Melissa M. , Chappell Grace A. , Thompson Chad M. , Haws Laurie C. 
Published: June 2022

HFPO-DA (ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate; CASRN 62037-80-3) is a component of the GenX technology platform used as a polymerization aid in the manufacture of some types of fluoropolymers. The liver is the primary target of toxicity for HFPO-DA in rodents and previous examination of hepatic transcriptomic responses in mice following oral exposure to HFPO-DA for 90 days showed induction of peroxisome proliferator-activated receptor signaling pathways, predominantly by PPARα, as well as increased gene expression of both peroxisomal and mitochondrial fatty acid metabolism. To further investigate the mechanism of liver toxicity, transcriptomic analysis was conducted on liver tissue from mice orally exposed to 0, 0.1, 0.5 or 5 mg/kg-bw/day HFPO-DA in a reproduction/developmental toxicity study. Hepatic gene expression changes demonstrated activation of the PPARα signaling pathway. Peroxisomal and mitochondrial fatty acid β-oxidation gene sets were enriched at lower HFPO-DA concentrations, and complement cascade, cell cycle and apoptosis related gene sets were enriched at higher HFPO-DA concentrations. These results support the reported histopathological findings in livers of mice from this study and indicate that the effects of HFPO-DA are mediated through rodent-specific PPARα signaling mechanisms regardless of reproductive status in mice.
Effectiveness of COVID-19 Vaccination in Preventing All-Cause Mortality among Adults during the Third Wave of the Epidemic in Hungary: Nationwide Retrospective Cohort Study
Authors: Pálinkás Anita , Sándor János 
Published: June 2022

Our investigation aimed to describe the all-cause mortality rates by COVID-19 vaccination groups in Hungary for an epidemic period (1 April 2021–20 June 2021) and a nonepidemic period (21 June 2021–15 August 2021), and to determine the vaccines’ effectiveness in preventing all-cause mortality utilizing nonepidemic effectiveness measures to adjust for the healthy vaccinee effect (HVE). Sociodemographic status, comorbidity, primary care structural characteristics, and HVE-adjusted survival difference between fully vaccinated and unvaccinated cohorts in the epidemic period had been computed by Cox regression models, separately for each vaccine (six vaccines were available in Hungary). Hazard ratio (HR) reduction in epidemic period corrected with nonepidemic period’s HR with 95% confidence interval for each vaccine was used to describe the vaccine effectiveness (VE). The whole adult population (N = 6,404,702) of the country was followed in this study (4,026,849 fully vaccinated). Each vaccine could reduce the HVE-corrected all-cause mortality in the epidemic period (VEOxford/AstraZeneca = 0.592 [0.518–0.655], VEJanssen = 0.754 [0.628–0.838], VEModerna = 0.573 [0.526–0.615], VEPfizer-BioNTech = 0.487 [0.461–0.513], VESinopharm = 0.530 [0.496–0.561], and VESputnik V = 0.557 [0.493–0.614]). The HVE-corrected general mortality for COVID-19 vaccine cohorts demonstrated the real-life effectiveness of vaccines applied in Hungary, and the usefulness of this indicator to convince vaccine hesitants.
ULUSLARARASI HAVAYOLU TAŞIMACILIĞINDA İKİ ŞEHİR ARASINDAKİ BASILI OLMAYAN BİR ÜCRETİN VE BELİRLENMEMİŞ İZİN VERİLEN MİL MİKTARI (MPM)’IN KURULMASI
Authors: SEMİZ ÇELİK Derya 
Published: June 2022

Havayolu yolcu taşımacılığında uluslar arası kuralları koyarak teknik konular dışında birçok konuda rekabeti düzenleyen kurum Uluslararası Hava Taşımacılığı Birliği (IATA International Air Transport Association)dir. IATA kurallarına göre koltuk ücreti hesaplarken kullanılacak ücretleri dünyadaki detayda olan şehirler seviyesinde tutmamaktadır. Bu noktada uçuş gerçekleştirilen ülkedeki nispeten daha az uçulan bölgelere ücret kurulurken ilgili ülkenin merkezi noktaları üzerinden ücret kurulumu yapılmaktadır. Bu çalışma da bu hesaplama şeklini konu almaktadır.
Çalışmada literatür çalışmasının ardından ücret ve izin verilen mil miktarı kurulumları yapılmıştır. Kurulumlara örnek teşkil etmesi adına tesadüfi belirlenen parkurlar için hesaplamalara da çalışmada yer verilmiştir. Elektronik biletlere yansıyan bir anlamda hesaplama özeti (Fare Calculation) olan yatay özet çizelgesine de yer verilmektedir.
Bu çalışma, havayollarının ücretlendirme politikalarının geliştirilmesinde gözden kaçan yada fırsat yaratabilecek detaylara dikkat çekmektedir.
Coronary heart disease and chronic kidney disease: the possibilities of PCSK9 inhibitors in the achievement of atherogenic lipoproteins target values
Authors: Mal G. S. , Kuznetsov A. A. 
Published: June 2022

Objective: Possibilities evaluation of achieving the target values of atherogenic lipoproteins in patients with coronary heart disease (CHD) in combination with renal dysfunction during drug correction with PCSK9 inhibitors.Material and methods: The study included 76 men with CHD with very high cardiovascular risk divided into 2 groups: without chronic kidney disease (CKD) (n = 39) and with stage IIIA–IIIB CKD (n = 37). All patients did not reach the target values of lowdensity lipoprotein cholesterol (LDL cholesterol) after 8 weeks of the maximum dose of atorvastatin and ezetimibe, which was the motivation for the use of PCSK9‑alirocumab inhibitors, with control of the lipid profile and glomerular filtration rate for 6 months.Results: In the group of patients with CHD, 87.1% of patients (n = 34) reached the target values of LDL cholesterol, the level of LDL cholesterol decreased from 4.41 ± 0.19 mmol to 1.28 ± 0.14 mmol (p < 0.001), in the group of patients with CHD + CKD stage IIIA–IIIB 56.7% of patients reached the target values (n = 21), the LDL cholesterol level decreased from 4.6 ± 0.2 mmol to 1.37 ± 0.09 mmol (p < 0.001). There was no statistically significant change in the glomerular filtration rate during the study.Conclusion: The results of this study demonstrate the obvious effectiveness of PCSK9 inhibitors in achieving LDL cholesterol target values in patients with coronary heart disease with a very high cardiovascular risk. During the study, a decrease in the level of LDL cholesterol by more than 70% was noted. The absence of CKD in CHD patients increases the chance of achieving LDL cholesterol target values by 81% (OR 0.19).
Mineral and bone metabolism in patients with idiopathic scoliosis depending on the magnitude of the deformity
Authors: Zeynalov Yu. L. , Diachkova G. V. , Burtsev A. V. , Sutyagin I. V. , Diachkov K. A. 
Published: June 2022

Objective: Analysis of the results of the study of mineral metabolism and bone formation markers in patients with idiopathic scoliosis, depending on the magnitude of the deformity.Material and methods: Based on the retrospective single‑center study in 30 patients diagnosed with scoliosis the preoperative parameters of calcium metabolism (total and ionized calcium, parathyroid hormone, 24‑hour urine calcium), phosphorus, bone formation markers (alkaline phosphatase, osteocalcin, P1NP in the blood), deoxypyridinoline in morning urine, blood levels of 25(OH)D have been analyzed. The patients were divided into 3 groups: with a deformity of 25–40 ° (group 1), 40–60 ° (group 2) and 60–80 ° (group 3) (n = 30). The mean age in all groups was 18.5 ± 4.7.Results: In patients with idiopathic scoliosis, alkaline phosphatase and P1NP significantly exceeded normal values in the first group, which indicated a more high‑turnover type of bone remodeling with a deficient level of 25(OH)D. A higher excretion of deoxypyridinoline and a decrease in phosphorus in blood in patients with a deformity of 60–80 ° suggest a violation of the ratio of the processes of synthesis and resorption in bone tissue.Conclusion: The study of mineral metabolism and all the main markers of bone formation made it possible to obtain a more complete picture of the state of metabolic processes in bone tissue, to obtain reliable data on the effect of some of them on the nature of bone remodeling and the magnitude of spinal deformity.
The epithelial-to-mesenchymal transition in cancer: pathogenetic features
Authors: Pasechnikova E. A. , Bodnya V. N. , Kadomtsev D. V. , Georgieva A. Yu. , Porhanov V. A. , Shevchuk D. D. 
Published: June 2022

The epithelial‑to‑mesenchymal transition (EMT) is a cellular biological process, that occurs in a wide range of cells and tissues and is triggered by complex regulatory networks involving transcriptional control with SNAIL, ZEB1, ZEB2, Twist, SLUG, E‑cadherin, vimentin, tumor microenvironment and genetic characteristics. EMT is represented by the multi‑stage development and transformation of cells of the epithelial phenotype into cells that acquire mesenchymal features of various severity. These quasi‑mesenchymal cells are characterized by stemness, tumor heterogeneity, increasing invasiveness, drug resistance and a tendency to distant metastasis, which leads to the proliferation of neoplastic cells, tumor dissemination and initiation of metastasis, which induces the therapy resistance and the oncological recurrence.This review is based on the latest scientific publications about the EMT phenomenon, indexed in PubMed. The aim of the study was to evaluate the biochemical and molecular pathogenetic mechanisms of EMT and the effect of EMT markers on the progression of neoplastic processes and the effectiveness of the treatment. Nowadays the proper EMT scheme that combines all the molecular transformations of sells with quasi‑mesenchymal phenotype doesn’t exist. But analyzing the features of this cellular program, we can find the proper therapy, that could be able to suppress the plasticity of cancer cells, prevent EMT induction by blocking contextual signals, and induce mesenchymal‑epithelial transition. All these aspects will lead to the reduction of the risk of tumor dissemination and the increase of the effectiveness of cancer treatment.
ظاهرة العدول في الاساليب الانشائية عند حسان بن ثابت الانصاري
Authors: Dr. Hammdy khalaf siuwd Al Rikabi  
Published: June 2022

تناولت هذه الدراسة ظاهرة العدول في الأساليب الانشائية عند حسان بن ثابت الانصاري .
حسان شاعر من الشعراء المخضرمين الذين دافعوا عن الدعوة الاسلامية وعرف حسان بمكانته المرموقة في الاسلام ‘فهو اكثر الشعراء الذين استعملوا المدح ،لنصرة الرسول (ص) لأعلاء كلمة الحق الالهي الدعوة الاسلامية التي امره الله بها .عاش حسان ستين عاما في الجاهلية وستين بعدها ، وقد افنى عمره في النصف الاخير منه في الدفاع عن الاسلام اذ كان مقاتلا شجاعا ضد مشركي قريش وقاتل قتالا شديدا من اجل نصرة الاسلام والمسلين لذا اتخذ من الشعر سلاحا فتاكا في نصرة الدين . لهذا كان شعره بعيدا عن التكلف الذي التزم به غيره من شعراء عصره ؛ بل كان يرسله كما جادة به سجيته ولكن نجده في بعض المواقف يضطر الى الارتجال فلا غرابة ان تتنوع اساليبه ومعانيه وتتباين الفاظه وان تجتمع في شعره اللين والبساطة والفخامة والغريب والمألوف . ويمكن القول إن شعر حسان بعد اسلامه بدا عليه الضعف ؛لان الاسلام نهى عن بعض الاغراض ، كالغزل ‘ والوصف وشعر اللهو والخمر ، وإقتصر على شعر المدح والرثاء والهجاء
تحليل الصراعات الأثنية في جمهورية جنوب أفريقيا وانعكاساتها على الأوضاع في القارة الأفريقية (دراسة في الجغرافية السياسية)
Authors: Mother. Dr. Adnan Abdullah Hammadi  
Published: June 2022

يتميز مجتمع جنوب أفريقيا بأنه يتألف من مجاميع مختلفة في الأصل والثقافة والدين واللون ، إذ تنحدر هذه المجاميع إلى اصول أفريقية أو اوربية أو اسيوية فضلاً عن الملونين الذين جاءوا نتيجة لاختلاط هذه المجموعات الأثنية ، فكان من الطبيعي ان يحدث صراع فيما بينها حول مختلف المصالح وكل مجموعة أثنية تحاول ان ترتبط بالمجتمع الذي انحدرت منه .
ويعد مجتمع دولة جنوب أفريقيا بيئة صالحة لنمو فكرة العنصرية وممارستها في الواقع الاجتماعي والاقتصادي والسياسي ، ويتكون سكان جنوب أفريقيا من اربع مكونات أثنية هم الأفارقة (79%) ، والبيض (10%) ، والملونون (8%) ، والآسيويون (3%) ، وان هذه الجماعات تجد لها امتداداً في داخل دول أخرى مجاورة وتؤدي تلك الامتدادات ادوار مهمة فيما يتصل بعلاقاتها مع دول الجوار سلباً وإيجاباً وهذا ما قد يتخذه صناع القرار السياسي لبلوغ غاياتهم ، إذ تعتمد الأنظمة السياسية على العصبية في تعزيز حكمها .
مفهوم الفلسفه الطاويه في كتاب أي.أر .أمنز الشعري شاطيء الاشجار
Authors: Assistant Professor Dr. Nadia Ali Ismael  
Published: June 2022

يتالف كتاب أي.أر.أمنز(1926-2001 ) الشعري شاطيء الاشجار ((1981 من 37 قصيده. يناقش البحث هذه القصائد من منضور فلسفة الطاويه والتي اتبعها الشاعر بدقه في كتابه.يظهر الكتاب بوضوح الكثير من ملامح الطبيعه والتي تتضمن تغيرات دينامكيه وتطور تدريجي لمختلف الكائنات الحيه .يصف الشاعر في اول سلسله من قصائده الصوره الحقيقيه للكون من خلال رؤيا عميقه للطاويه والتي تظهر جليا من خلال تفاعل الانسان مع الطبيعه.توضح القصائد تقارب الطاويه من الفلسفه البوذيه في التركيز على الروح والحياة بعد الموت والتامل. كما تبين القصائد تفوق الطبيعه وحقيقة الموت والتناقض الذي يخترق الطبيعه متمثلا بالموت والحياة والحقيقه والمظهر كما تؤكد القصائد الارتباط القوي بين الانسان والطبيعه والذي يكون بحد ذاته بنائا الا اذا تدخل الانسان بطريقه هدامه. يتوصل البحث الى حقيقة ان الانسان لم ولن يشعر بالوحده اذا ما اقترب وارتبط بالطبيعه .
اثر الاسلوب التدريبي في تطوير الاتزان الحركي ومهارة الوقوف على اليدين في الجمباز للطالبات
Authors: Intisar Sabah Ahmed  , Prof. Dr. Esraa Yassin Abdel Karim  
Published: June 2022

اثر الاسلوب التدريبي في تطوير الاتزان الحركي ومهارة الوقوف على اليدين في الجمباز
هدف البحث الى إعداد وحدات تعليمية وفق الاسلوب التدريبي لتطوير الاتزان الحركي ومهارة الوقوف على اليدين في الجمباز .والتعرف على الاسلوب التدريبي لتطوير الاتزان الحركي ومهارة الوقوف على اليدين في الجمباز . وقد استخدمت الباحثتان المنهج التجريبي بتصميم مجموعتين متساويتين مجتمع وعينة البحث اذ حدد مجتمع البحث بالطريقة العمدية من طالبات قسم التربية الرياضية / كلية التربية الأساسية/ الجامعة المستنصرية إذ بلغت عينة البحث 22 طالبة من طالبات المرحلة الأولى الدراستين الصباحية والمسائية من أصل مجتمع البحث البالغ 44 طالبة وبذلك تكون نسبة العينة 50% .عمدت الباحثتان إلى تقسيم العينة بطريقة عشوائية إلى مجموعتين ضابطة وتجريبية عن طريق سحب أسماء بواسطة القرعة ولغرض ضمان خط الشروع الواحد للمجموعتين لجأت الباحثتان إلى استخدام قانون T-Testللعينات المستقلة والمتساوية بالعدد في المتغيرات التابعة للبحث وظهرت جميع النتائج ذات دلالة غير معنوية في الاتزان الحركي والوقوف على اليدين وبعد ذلك قامتا بأجراء التكافؤ ثم تم اجراء الاختبار القبلي وتم تصميم وحدة تعليمية بالأسلوب التدريبي زمن الوحدة 90 دقيقة وبعدها تم اجراء الاختبار البعدي وقد استخدمتا الحقيبة الاحصائية للتوصل الى نتائج بدورها بنيت عليها استنتاجات ومن اهمها للأسلوب التدريبي التأثير في قدرة الاتزان الحركي ومهارة الوقوف على اليدين . وللأسلوب المتبع اثر ايضا في المتغيرات التابعة ولكن ليس بنفس قدر الاسلوب التدريبي. ظهور تباين في نسب التطور بين الاختبارات القبلية والبعدية للمجموعتين الضابطة والتجريبية في قدرة ( الاتزان الحركي) ولصالح الاختبارات البعدية . ظهور تباين في نسب التطور بين الاختبارات البعدية للمجموعتين الضابطة والتجريبية في مهارات (الوقوف على اليدين) ولصالح المجموعة التجريبية . وامن اهم التوصيات هي ضرورة اعتماد الاسلوب التدريبي لتطوير القدرات البدنية والحركية الخاصة لتطوير مهارات الحركات الأرضية في الجمباز . والتأكيد على تدريس وتعليم القدرات الحركية الخاصة بمهارات الحركات الأرضية وعدم إغفال أي منها
Association Between the Managerial Ability and Long-Term Performance in Mergers and Acquisitions
Authors: Putri Adinda Ayu Jelita , Suryaningrum Diah Hari 
Published: June 2022

Mergers and acquisitions are still a hot topic to be discussed and are often seen as a high priority issue worldwide as a controversial decision because it has a very complex impact. This study aims to test and analyze whether managerial ability has an effect on long-term performance and 1, 2, and 3 years after mergers and acquisitions. In addition, this study also aims to examine whether managerial ability in horizontal acquisitions has an effect on long-term operating performance rather than diversified acquisitions. This research uses quantitative research. The sample of this research is 14 public acquisition companies with a research period of 10, 9, and 8 years after mergers and acquisitions are listed on the Indonesia Stock Exchange and KPPU in 2010-2012. The results showed that managerial ability had an effect on operating performance 1 year after mergers and acquisitions. Other research results indicate that managerial ability has no effect on operating performance 2 and 3 years after mergers and acquisitions and long-term performance. In addition, managerial ability in horizontal acquisitions has no effect on long-term performance and 1, 2, and 3 years after mergers and acquisitions than diversified acquisitions..