bluuebunny/crossref_metadata_2025_split huggingface dataset:
A C‐band 370 W MMIC high‐power PIN limiter with heterogeneous integration
Authors: Dai Zhou , Li Chunyu , Yan Junda , Dai Jiayun , Zhang Tiancheng , Bao Huaguang , Ding Dazhi 
Published: December 2022

AbstractThis paper designs a mesa‐structured monolithic microwave integrated circuit (MMIC) limiter working in C‐band. The quasi‐vertical Si‐based PIN diodes are heterogeneously integrated on the SiC substrate with high thermal conductivity, such that the parasitic parameters are greatly reduced and the power capacity is enhanced. According to the measured results, a maximum insertion loss of 1.1 dB and a minimum return loss of 17.69 dB for both input and output terminals are realized to cover the 5–6 GHz frequency range. The flat leakage of 23 dBm is achieved for a 150 W continuous wave and 370 W pulse input signal level. We believe the proposed MMIC limiter provides an effective tool that can be used in the transmit‐receive modules working in C‐band.
Lessons learned from child health care nurses' experiences of teaching infant massage groups: A qualitative interview‐based study
Authors: Isaksson Josefin A. , Hedov Gerth , Garmy Pernilla 
Published: December 2022

AbstractAimTo describe child health care nurses' experiences of teaching infant massage in parent groups.DesignThis was an exploratory‐descriptive qualitative study based on individual interviews.MethodQualitative semi‐structured interviews were conducted with child health care nurses (N = 9) according to the COREQ guidelines and analyzed with qualitative content analysis.ResultsFive categories were identified: (1) Infant massage can promote attachment between parents/guardians and their children; (2) Infant massage can have a calming impact; (3) Stress and lack of time can be challenging; (4) The composition of parent groups can be important and (5) The child health care nurse can observe parents'/guardians' relationships with their children. Child health care nurses are uniquely familiar with infant massage and the benefits it provides both parents/guardians and their infants. Specifically, infant massage has a calming effect that reduces stress and strengthens the relationship between infants and their parents/guardians.Patient or Public ContributionChild health care nurses were interviewed.
Electrochemical Detection of Dopamine using a Phenyl Carboxylic Acid‐Functionalized Electrode Made by Electrochemical Reduction of a Diazonium Salt
Authors: Anjum Saima , Lou Baohua , Tahir Amiza , Aziz‐ur‐Rehman  , Rehan H. Shah Gilani M. , Xu Guobao 
Published: December 2022

AbstractA glassy carbon electrode (GCE) has been modified by an in situ electrochemical reduction of an aryldiazonium salt generated from the reaction of 4‐aminobenzoic acid and sodium nitrite in acidic ethanolic solution. The as‐prepared phenyl carboxylic acid‐modified glassy carbon electrode has been, for the first time, used for the electrochemical determination of dopamine. Under optimal experimental parameters, outstanding electrocatalytic activity, high sensitivity at a LOD of 5.6×10−9 m, and broad linearity of 0.1 to 1000 μm were obtained. The crafted electrochemical platform demonstrated excellent stability, specificity, and anti‐interference capability towards the sensing of dopamine.
Evaluation of shear piezoelectric coefficients by a bimorph cantilever technique for extruded and oriented poly(l‐lactide) films
Authors: Ben Achour Mohamed Aymen , Samuel Cédric , Rguiti Mohamed , Barrau Sophie , Courtois Christian , Lacrampe Marie‐France 
Published: December 2022

AbstractUniaxially stretched poly(l‐lactide) (US‐PLA) films display shear piezoelectric properties of interests for smart applications. However, the measurement of these properties is quite challenging and a simple technique based on bimorph cantilevers is here used. This technique is validated with commercial piezoelectric poly(vinylidene fluoride) (PVDF) films. A piezoelectric coefficient d31 close to 19 pm/V is then obtained with a precision close to 5% and a good accuracy to expected values. For US‐PLA films made by extrusion—machine‐direction orientation, shear piezoelectric coefficients d14 up to 5.9 pm/V are found. Relevant trends can be captured but a low precision on d14, close to 10%, is highlighted. This behavior is probably related to film thickness heterogeneities arising from the extrusion processing at the laboratory scale. Piezoelectric voltage coefficients (g14) and electromechanical coupling coefficients could be also easily obtained with additional measurements of the dielectric permittivity and mechanical compliance. Outstanding g14 coefficients up to 320 mV.m/N are confirmed for US‐PLA films with a precision close to 20%. The bimorph cantilever technique consequently represents a simple and reliable technique to evaluate piezoelectric properties of soft materials, in particular shear piezoelectric properties of US‐PLA films for future developments and optimizations at the pilot scale.
Impact of viral respiratory infections on pulmonary exacerbations in children with cystic fibrosis
Authors: Gonzalez‐Rosales Noel , Kasi Ajay S. , McCracken Courtney E. , Silva George L. , Starks Miah , Stecenko Arlene , Guglani Lokesh 
Published: December 2022

AbstractBackgroundViral respiratory infections trigger pulmonary exacerbations (PEs) in children with cystic fibrosis (CF), but their clinical impact is not well understood.MethodsA retrospective review of pediatric patients with CF who underwent nasopharyngeal respiratory viral panel testing during hospitalization for a PE between 2011 and 2018 was conducted. Patients were dichotomized into viral‐positive and viral‐negative groups. The results of spirometry, respiratory cultures, duration of hospitalization, and risk for subsequent PEs were analyzed.ResultsNinety‐five patients had 210 hospitalizations for PE (viral‐positive = 71/210, 34%) during the study period. Rhinovirus/enterovirus was the most common virus (52/71, 73%) identified. Viral‐positive patients were younger (p < 0.001), had higher baseline forced expiratory volume in 1 s (FEV1) (p = 0.037), continued to maintain higher FEV1 at 3 and 6 months following PE (p = 0.003 and 0.002, respectively), and had a shorter duration of hospitalization (p = 0.006) compared to the viral‐negative group. There was no difference between the two groups in the rate of recovery of FEV1 at 3 and 6 months following PE (p = 0.71 and 0.405, respectively), time to the next PE (hazard ratio = 1.34, p = 0.157), number of subsequent PEs in 6 months (p = 0.99), or Pseudomonas aeruginosa (PA) acquisition (p = 0.707).ConclusionsIn this single pediatric CF center cohort, one‐third of PEs requiring hospitalization were associated with a viral infection, with rhinovirus/enterovirus being the most common. Viral‐positive PEs were not associated with a greater decline or delayed recovery of lung function, increased risk for PA acquisition, shortened duration to next PE, longer hospital stay, or an increase in the frequency of subsequent PEs in 6 months compared to viral‐negative PEs.
Thymoquinone attenuates hepatic lipid accumulation by inducing autophagy via AMPK/mTOR/ULK1‐dependent pathway in nonalcoholic fatty liver disease
Authors: Zhang Di , Zhang Yinghui , Wang Zhilan , Lei Lei 
Published: December 2022

AbstractThymoquinone (TQ) has been proved to exert wide‐ranging pharmacological activities, with anti‐inflammatory, antioxidant, anticonvulsant, antimicrobial, anti‐tumor, and antidiabetic properties. In this study, we investigated the beneficial effects of TQ on a high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease (NAFLD) in C57BL/6 N mice in vivo and free fatty acid (FFA)‐induced human hepatocellular carcinoma HepG2 cells in vitro. Further, the underlying mechanisms of TQ to promote hepatic autophagy were also discovered. Data showed that TQ caused (p < 0.01) body weight reduction, improved glucose homeostasis, alleviated hepatosteatosis, and decreased hepatic lipid accumulation related to the induction of autophagy in HFD‐fed mice. In vitro, TQ obviously increased (p < 0.01) autophagic flux in FFA‐induced HepG2 cells and consequently reduced the lipid accumulation in combination with activation of AMPK/mTOR/ULK1 signaling pathways. Moreover, pharmacological inhibition of the AMPK pathway by addition with AMPK inhibitor Compound C (CC) or silence of ULK1 by transfection with siRNA(ULK1) into HepG2 cells reversed these beneficial effects of TQ on triggering hepatic autophagy and reducing lipid accumulation (p < 0.01). Taken together, these results suggested that TQ alleviated hepatic lipid accumulation by triggering autophagy through the AMPK/mTOR/ULK1‐dependent signaling pathway. Our study supports a potential role for TQ in ameliorating NAFLD.
Predictors of adverse perinatal and maternal outcomes of instrumental vaginal delivery at a tertiary setting in Ethiopia: A cross‐sectional study
Authors: Sium Abraham Fessehaye , Gudu Wondimu , Lucero‐Prisno Don Eliseo III , Tilahun Aida 
Published: December 2022

AbstractObjectiveTo determine the rate of instrumental vaginal delivery (IVD) and the predictors of adverse maternal and fetal outcomes associated with it in an Ethiopian setting.MethodsA cross‐sectional study was conducted from October 1, 2018, to January 31, 2019, at St. Paul's Hospital Millennium Medical College (SPHMMC) (Addis Ababa, Ethiopia). Data on obstetric characteristics, perinatal and maternal outcomes of women who delivered through IVD were collected prospectively, using a structured questionnaire. Data were analyzed using SPSS version 22 and descriptive analysis was applied to analyze baseline characteristics. Multivariable logistic regression model was fitted to predict the association between short‐term complications of IVD and their determinants. Odds ratio, 95% CI, and p‐value < 0.05 were used to present significance of study findings.ResultsThere were 3165 deliveries during the study period, out of which 241 (7.6%) were instrumental vaginal deliveries. Sequential use of instrumental delivery (AOR = 4.82 [95% CI = 2.10–27.29] and AOR = 6.43 [95% CI = 1.19–34.73], for maternal and fetal complications, respectively) was associated with increased both maternal and fetal complications. Three number of pulls during the extraction was associated with increased fetal complications (AOR = 1.19 [95% CI = 1.05–1.67]).ConclusionThe rate of instrumental delivery rate in our setting is high with sequential use of instrumental delivery found to be associated with increased adverse maternal and fetal outcomes while three number of pulls were associated with increased fetal adverse outcomes.
Glycopeptide characterization of Sf9‐derived SARS‐CoV‐2 spike protein recombinant vaccine candidates expedited by the use of glycopeptide libraries
Authors: Miller Roland M. , Perkins George L. , Bush David , Tartiere Aude , DeGraan‐Weber Nick 
Published: December 2022

RationaleWe report the N‐glycosylation pattern of Sf9 insect cell‐derived recombinant spike proteins being developed as candidate vaccine antigens for SARS‐CoV‐2 (COVID‐19) (Sanofi). The method has been optimised to produce peptides with single, isolated glycosylation sites using multiple protease digests. The development and use of glycopeptide libraries from previous developmental phases allowed for faster analysis than processing datasets from individual batches from first principles.MethodsPurified spike proteins were reduced, alkylated, and digested with proteolytic enzymes. Three different protease digests were utilised to generate peptides with isolated glycosylation sites. The glycopeptides were then analysed using a Waters Q‐TOF while using a data‐dependent acquisition mass spectrometry experiment. Glycopeptide mapping data processing and glycan classification were performed using Genedata Expressionist via a specialised workflow that used libraries of previously detected glycopeptides to greatly reduce processing time.ResultsTwo different spike proteins from six manufacturers were analysed. There was a strong similarity at each site across batches and manufacturers. The majority of the glycans present were of the truncated class, although at sites N61, N234, and N717/714 high mannose structures were dominant and at N1173/1170 aglycosylation was dominant for both variant proteins. A comparison was performed on a commercially available spike protein and our results were found to be similar to those of earlier reports.ConclusionsOur data clearly show that the overall glycosylation pattern of both spike protein variants was highly similar from batch to batch, and between materials produced at different manufacturing facilities. The use of our glycopeptide libraries greatly expedited the generation of site‐specific glycan occupancy data for a large glycoprotein. We compared our method with previously obtained data from a commercially available insect cell‐derived spike protein and the results were comparable to published findings.
Sedimentation and regulation technologies in the Three Gorges Reservoir
Authors: Chunhong Hu , Chunming Fang 
Published: December 2022

AbstractSedimentation is one of the key technical problems present throughout feasibility demonstration, design, construction, and operation of the Three Gorges Project. Since the Three Gorges Reservoir (TGR) began impoundment operation in 2003, important progress has been made in sedimentation and regulation technologies through systematic research and practices. This paper reveals the asynchronous propagation pattern of flood and sediment peak inflows, sediment movement in the backwater area during drawdown period, sediment flocculation, and sediment deposition that compromises the flood control reservoir storage, and puts forward new sediment regulation techniques, including sediment peak discharge regulation during flood season, siltation reduction in the backwater area during drawdown period, dynamic adjustment of the reservoir level during flood season, and joint sediment regulation in cascade reservoirs. A real‐time monitoring, forecasting and dynamic regulation platform for water and sediment inflow in the TGR was developed; a new mode of dynamic sediment regulation called “regulating sediment for greater benefits” is proposed, which addresses the constraints of sedimentation on the optimal operation of TGR. By enabling more flexible operation, this mode improves the process and pattern of sedimentation, ensures the safety of reservoir operation, and significantly augments the comprehensive benefits of the TGR.
Breathable Lignin Nanoparticles as Reversible Gas Swellable Nanoreactors
Authors: Moreno Adrian , Delgado‐Lijarcio Javier , Ronda Juan C. , Cádiz Virginia , Galià Marina , Sipponen Mika H. , Lligadas Gerard 
Published: December 2022

AbstractThe design of stimuli‐responsive lignin nanoparticles (LNPs) for advanced applications has hitherto been limited to the preparation of lignin‐grafted polymers in which usually the lignin content is low (<25 wt.%) and its role is debatable. Here, the preparation of O2‐responsive LNPs exceeding 75 wt.% in lignin content is shown. Softwood Kraft lignin (SKL) is coprecipitated with a modified SKL fluorinated oleic acid ester (SKL‐OlF) to form colloidal stable hybrid LNPs (hy‐LNPs). The hy‐LNPs with a SKL‐OlF content ranging from 10 to 50 wt.% demonstrated a reversible swelling behavior upon O2/N2 bubbling, increasing their size – ≈35% by volume – and changing their morphology from spherical to core‐shell. Exposition of hy‐LNPs to O2 bubbling promotes a polarity change on lignin‐fluorinated oleic chains, and consequently their migration from the inner part to the surface of the particle, which not only increases the particle size but also endows hy‐LNPs with enhanced stability under harsh conditions (pH < 2.5) by the hydration barrier effect. Furthermore, it is also demonstrated that these new stimuli‐responsive particles as gas tunable nanoreactors for the synthesis of gold nanoparticles. Combining a straightforward preparation with their enhanced stability and responsiveness to O2 gas these new LNPs pave the way for the next generation of smart lignin‐based nanomaterials.
Enamels analysis of Doucai porcelain with Chenghua mark by non‐destructive micro‐EDXRF
Authors: Yuwu Gong , Yingfei Xiong , Enyuan Wang , Jie Chen 
Published: December 2022

AbstractThe Chenghua Doucai of the Ming Dynasty represents the highest level of craftsmanship among enamelled porcelain, and it remained popular throughout the Ming and Qing Dynasties. Consequently, Doucai porcelain with a pseudo‐Chenghua mark was produced almost continuously after the Chenghua reign. In this article, non‐destructive energy dispersive micro x‐ray fluorescence (micro‐XRF) is used to analyse Doucai wares with Chenghua mark from the Ming and Qing Dynasties and modern period. Using micro‐XRF mapping technology, the different elemental maps in the blue, green, red, yellow enamels demonstrate that the Doucai is fired with a various colouring materials. The blue is coloured by cobalt, the green is coloured by copper, and the red and yellow are coloured by a lot of iron and a few of iron, and lead in all enamels except for the underglaze blue with different contents. Even though the primary enamels of Doucai wares with the Chenghua mark are similar, the wares made in the Qing Dynasty display more types of enamels than Chenghua reign's. For instance, there are two types of red enamels; the darker red enamel contains manganese (Mn) in addition to iron (Fe), and the modern yellow enamels of Doucai contain titanium (Ti) in addition to iron (Fe). This study compared the changes of colouring materials for Doucai of different times and demonstrated that the micro‐XRF elemental mapping technology is a valuable tool to reveal the compositional characteristics and ware production procedures.
Microvascular anastomosis of the human lacrimal gland: a concept study towards transplantation of the human lacrimal gland
Authors: Holtmann Christoph , Roth Mathias , Filler Timm , Bergmann Ann Kathrin , Hänggi Daniel , Muhammad Sajjad , Borrelli Maria , Geerling Gerd 
Published: December 2022

Abstract

Introduction
Severe aqueous tear deficiency is caused by primary or secondary main lacrimal gland insufficiency. The transplantation of a human lacrimal gland could become a potential treatment option to provide physiological tears with optimal properties. To this end, we performed an ex vivo study to develop a surgical strategy that would ensure a vascular supply for a lacrimal gland transplant using microvascular techniques.

Material and methods
Five cadaver heads were used to perform a lateral orbitotomy in order to identify the vascular pedicle and the lacrimal gland itself. The principal feasibility and the time of the required surgical steps for an intraorbital microvascular re-anastomosis of the human lacrimal gland were documented. Patency and potential leakage of the anastomosis were tested with hematoxylin intraoperatively. Postoperatively, routine histological, as well as scanning electron microscopy (SEM) of the gland and vascular anastomosis, were performed.

Results
The vascular pedicle of all five glands could be isolated over a minimum stretch of at least 1 cm, severed, and successfully reanastmosed microsurgically. Time for arterial anatomization (n = 4) was 23 ± 7 min and 22 ± 3 min for the vein (p = 0.62). The total time for the entire microvascular anastomosis was 46 ± 9 min. All anastomosis were patent upon testing. SEM revealed well-aligned edges of the anastomosis with tight sutures in place.

Conclusion
Our study demonstrates as proof of principle the feasibility of intraorbital microvascular re-anastomosis of a human lacrimal gland within the presumed window of ischemia of this tissue. This should encourage orbital surgeons to attempt lacrimal gland transplantation in humans in vivo.
Einfluss der Beimpfung auf die Filiformkorrosionsprüfung
Authors: Plagemann Peter 
Published: December 2022

ZusammenfassungBei der Filiformkorrosionsprüfung werden beschichtete und geritzte Prüfkörper vor der Klimaauslagerung üblicherweise Salzsäuredämpfen ausgesetzt, um das Fadenwachstum zu initiieren. Dieser Vorgang wird oftmals als „Beimpfen“ bezeichnet. Etliche Faktoren in der Durchführung dieser Prozedur können jedoch die Prüfergebnisse beeinflussen. Hierzu wurden systematische Untersuchungen unter Verwendung der faktoriellen Versuchsplanung („Design of Experiment“ – DoE) mit der entsprechenden statistischen Auswertung gemacht, um die Wirkung ausgewählter Prüfparameter auf das Prüfergebnis bewerten zu können. Desweiteren wurden auch andere Methoden zur Beimpfung untersucht um zu zeigen, ob diese als Alternative zur klassischen HCl-Dampf-Beimpfung geeignet sind.
How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?
Authors: Imamura Masayuki , Komoto Izumi , Taki Yoshiro 
Published: December 2022

AbstractIn patients with multiple endocrine neoplasia type 1 syndrome (MEN 1) and Zollinger–Ellison syndrome (ZES), gastrinomas arise from the duodenum, about 60% are multiple, and about 15% of patients have coexisting pancreatic gastrinomas, which can be localized by the selective arterial secretagogue injection test (SASI test). The guidelines (GLs) by the Japanese Neuroendocrine Tumor Society (JNETS) recommend surgical resection for functioning duodenopancreatic neuroendocrine tumors (NETs), including gastrinomas, in patients with MEN1 (Grade A, 100% agreement among members). Conversely, the GLs of the National Comprehensive Cancer Network (NCCN) in the USA recommend observation and treatment with proton pump inhibitors (PPIs) or exploratory surgery for occult gastrinomas. An international Consensus Statement (ICS) from the European Union (EU) also does not recommend resection of gastrinomas in patients with MEN1, despite some surgeons having reported surgery being curative for gastrinomas in MEN1 patients. In this review, we discuss the serious side effects and tumorigenic effects of the prolonged use of PPIs and the safety and curability of surgery, supported by our results of curative surgery for gastrinomas in 20 patients with MEN1 over 30 years. We conclude that surgery should be the first-line treatment for gastrinomas in MEN1 patients.
A Novel Compact High Gain Wide-Band Log Periodic Dipole Array Antenna for Wireless Communication Systems
Authors: Ibrahim Islam M. , Ahmed Mohamed I. , Abdelkader Hala M. , Elsherbini M. M. 
Published: December 2022

Abstract
This paper implies a prototype for a broad-band log periodic dipole antenna (LPDA) with dimensions of 20 × 40 × 0.508 mm3 equipped with directors. The LPDA is based on Roger’s RT5880 with εr = 2.2. The 4-arms with alternative stubs constitute the LPDA, which is evenly spaced on both lines. At the substrate’s back, the 50Ω main feeder line is placed on partial ground. The directors are also incorporated and studied in a regular matrix at a predetermined distance to improve gain, further reduce side lobes, and widen the frequency band. The performance of the antenna covers a wide spectrum of millimeter waves ranging from 26 up to 44 GHz. The realized gain for the antenna is 8.97, 11.96, 13.96, and 14.29 dB at 28 GHz, 35 GHz, 38 GHz, and 43 GHz, respectively. The total gain is 14.29 dB as a peak gain. The antenna was designed and tested for 5G communication applications in autonomous vehicles, and the design cost for the antenna is low in comparison to dielectric lenses. The model exhibits symmetrical radiation patterns for the antenna range. The results of the simulations and the testing of the implemented antenna elements coincide quite well. The proposed design outperforms earlier work in this field.