bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone bruising severity after anterior cruciate ligament rupture predicts elevation of chemokine MCP-1 associated with osteoarthritis
Authors: Keil Lukas G. , Onuscheck Douglas S. , Pratson Lincoln F. , Kamath Ganesh V. , Creighton Robert A. , Nissman Daniel B. , Pietrosimone Brian G. , Spang Jeffrey T. 
Published: April 2022

Abstract
Purpose
Anterior cruciate ligament rupture is associated with characteristic bone contusions in approximately 80% of patients, and these have been correlated with higher pain scores. Bone bruising may indicate joint damage that increases inflammation and the likelihood of posttraumatic osteoarthritis. We sought to characterize the severity of bone bruising following acute anterior cruciate ligament injury and determine if it correlates with synovial fluid and serum levels of the proinflammatory chemokine monocyte chemoattractant protein-1 associated with posttraumatic osteoarthritis.

Methods
This was a retrospective analysis of data collected prospectively from January 2014 through December 2016. All patients who sustained an acute ligament rupture were evaluated within 15 days of injury, obtained a magnetic resonance imaging study, and underwent bone-patellar-tendon-bone autograft reconstruction were offered enrollment. The overall severity of bone bruising on magnetic resonance imaging was graded (sum of 0–3 grades in 13 sectors of the articular surfaces). Serum and synovial fluid levels of monocyte chemoattractant protein-1 were measured within 14 days of injury, and serum levels were again measured 6 and 12 months following surgery. Separate univariate linear regression models were constructed to determine the association between monocyte chemoattractant protein-1 and bone bruising severity at each time point.

Results
Forty-eight subjects were included in this study. They had a mean age of 21.4 years and were 48% female. Median overall bone bruising severity was 5 (range 0–14). Severity of bone bruising correlated with higher synovial fluid concentrations of monocyte chemoattractant protein-1 preoperatively (R2 = 0.18, p = 0.009) and with serum concentrations at 12 months post-reconstruction (R2 = 0.12, p = 0.04).

Conclusions
The severity of bone bruising following anterior cruciate ligament rupture is associated with higher levels of the proinflammatory cytokine monocyte chemoattractant protein-1 in synovial fluid acutely post-injury and in serum 12-months following anterior cruciate ligament reconstruction. This suggests that severe bone bruising on magnetic resonance imaging after ligament rupture may indicate increased risk for persistent joint inflammation and posttraumatic osteoarthritis.

Level of evidence
III ― retrospective cohort study.
ALK Inhibitors in Patients With ALK Fusion–Positive GI Cancers: An International Data Set and a Molecular Case Series
Authors: Ambrosini Margherita , Del Re Marzia , Manca Paolo , Hendifar Andrew , Drilon Alexander , Harada Guilherme , Ree Anne Hansen , Klempner Samuel , Mælandsmo Gunhild Mari , Flatmark Kjersti , Russnes Hege G. , Cleary James M. , Singh Harshabad , Sottotetti Elisa , Martinetti Antonia , Randon Giovanni , Sartore-Bianchi Andrea , Capone Iolanda , Milione Massimo , Di Bartolomeo Maria , Pietrantonio Filippo 
Published: April 2022

PURPOSE In GI cancers, anaplastic lymphoma kinase ( ALK) rearrangements are extremely less frequent than in non–small-cell lung cancer but may be important to offer personalized strategies of treatment in selected patients. Data about the activity and efficacy of ALK inhibitors (ALKi) in GI cancers are scarce. MATERIALS AND METHODS We assembled a clinical and molecular international data set of pretreated patients with metastatic or nonresectable cancers of GI primary tumor origin with documented ALK rearrangement treated with at least one line of ALKi. Measurable disease as per RECIST 1.1 was required for response analysis. RESULTS Primary tumor sites were distributed as follows: 5 (38%) pancreas, 3 (23%) right colon, and 1 (8%) for each one of gastric, duodenal, rectal, left colon, and biliary tract sites. Seven patients (54%) were treated with alectinib, 5 (38%) with crizotinib, and 1 (8%) with entrectinib. After disease progression, five patients (38%) received a subsequent ALKi treatment line, and at the time of data cutoff date, treatment was still ongoing in two patients. Five of 12 evaluable patients (41%) achieved a partial response to first-line ALKi, five patients (41%) had stable disease, and 2 (17%) had progressive disease. No complete responses were registered. At a median follow-up of 39.6 months (interquartile range: 19.8-59.5), the median progression-free survival was 5.0 months (95% CI, 3.68 to no response) and the median overall survival was 9.3 months (95% CI, 5.46 to no response). CONCLUSION Treatment with ALKi provides remarkable responses and clinical benefit in pretreated patients with ALK fusion–positive GI malignancies. Despite the rarity, ALK rearrangements represent an important therapeutic target in individual pretreated patients with GI solid tumors. Further work providing prospective clinical validation of this target is needed.
The Addicted Self
Authors: Cree Jose 
Published: April 2022

Abstract
This article explores the formation and characterization of early modern addiction through the interactions of mind, body, and will, focusing particularly on the work of the sixteenth-century Christian philosopher Pierre de La Primaudaye. In La Primaudaye’s writings addiction is a wholly internalized behavior, the product of repeated interactions within the mind. Intended for the purpose of cultivating virtuous behaviors, these interactions could become corrupted, resulting in negative addictions formed between overwhelming passions, a clouded judgment, and an inflexible will. The specific types of addiction a person inclined toward were determined by a host of variables, including temperament, age, and gender. As this article reveals, in early modern accounts of addicted behavior young men were associated with lust and old men with contemplation, while women were considered more vulnerable to all addictions, virtuous and sinful. The image of addiction that emerges from this examination is one not of a disease or a disorder, but of a natural function of the body that could on occasion be led astray.
Opium and Logistical Nightmares
Authors: Zieger Susan 
Published: April 2022

Abstract
This essay argues that opium’s pivotal role in nineteenth-century political economy and aesthetics constructed addiction as a relationship between labor and capital that has persisted throughout the twentieth and into the twenty-first century. Nineteenth-century discourses on opium addiction frame it as a crisis of sovereignty for individuals and masses in ways that veil its relationships to labor, collectivity, and community. Yet addiction arises within broad systems as much as it does within individuals: in this exemplary case, of labor, empire, opium, and logistics. This essay rereads nineteenth-century discourses of opium addiction through “the logistical sublime,” in which all manufacturing and distribution processes go smoothly, and “the logistical nightmare,” in which they descend into chaos. It reframes opium addiction as a logistical technique that secured and maintained the preeminence of British, and later, Chinese and US imperial capital.
All Aboard
Authors: Lansky Ellen 
Published: April 2022

Abstract
This essay situates Ernest Hemingway’s iconic “Hills Like White Elephants” as a short story about drinking. From this perspective, Hemingway’s story enables readers to experience a personal and deeply felt emotional engagement with the characters, the scene, and the situation. Moreover, his technique enlists readers as “drinking buddies” and provides an entrée into the culture of alcohol. Despite the macho image that Hemingway himself helped construct and deploy, his work invites women into the scene and, indeed, centralizes a key figure often overlooked in the history of modern American fiction criticism: the drinking woman.
Latest developments and scope of Health Technology Assessment in India: Tapping into the future
Authors: Rajwar Eti , Parsekar Shradha S. , Pundir Prachi , Brand Helmut , Brand Angela 
Published: April 2022

Health Technology Assessment (HTA) is a multifaceted approach for informing policy by considering social, medical, economic and ethical aspects in a systematic and transparent manner. HTA is an important tool for decision-making, priority-setting and for resource allocation, leading to Universal Health Coverage (UHC). The importance of HTA becomes more pronounced in developing countries such as India. In this review, we have summarised the status and future scope of HTA in India after referring to the scientific literature available in the form of journal articles and government reports. HTA supports prioritisation of healthcare services to be included in UHC and the provision of affordable and quality healthcare services in India. India established ‘HTA in India’ (HTAIn) in January 2017 as a starting point in HTA activities and this centre conducts HTA studies of various methodologies upon receiving requests from the different central and state departments. HTA in India is a relatively new concept and the processes are not streamlined compared to countries where HTA is established. Although an HTA manual is present for guiding the HTA process in India, there is lack of clarity on the HTA information considered for translating evidence into policy or practice. Additionally, there is a dearth of individual capacity to undertake high quality HTA in the country. HTAIn initiative showcases India’s political commitment towards achieving UHC and for HTA. However, there is an imminent need to expand the role of the technical partners and regional resource hubs in capacity building in HTA by involving the private sector in HTA processes.
Factors affecting access to health services by older adults in an urban community in Thailand: a cross-sectional study
Authors: Jirathananuwat Areeya 
Published: April 2022

Background: The impending rapid change in Thailand’s older population has many important implications for health policy, especially older adults’ health problems, which are major cause of them accessing health services. This study aimed to study factors affecting access to health services for older adults in urban communities in Thailand, as well as performing a situational survey of health service utilization. Methods: This cross-sectional study included 886 older adults from four types of urban communities (slum, city, suburban, and community building). Data were collected using an interview questionnaire. Information about health service variables were extracted and followed the five dimensions of accessibility by Penchansky & Thomas: availability, accessibility, accommodation, affordability and acceptability. Data were analyzed using percentage mean and standard deviation (SD). Analysis of factors affecting access to health service was performed using Logistic regression. Results: The utilization of health services was high among five dimensions. They were composed of availability (mean 4.2, SD.=0.59), accessibility (mean 4.1, SD.=0.69), accommodation (mean 3.9, SD.=0.67), affordability (mean 4.2, SD.= 0.62), and acceptability (mean 4.1, SD.=0.62). A summary of all dimensions revealed a mean of 4.1 (SD.= 0.52). Factors affecting older adults access to health services were using health insurance rights for health care service, and concern about the necessity of health care. Conclusions: Encouraging older adults to change their health insurance rights to the nearest hospital and promoting the provision of holistic health information, which will support older adults in accessing more health services to improve their health outcomes.
A multi-spectral myelin annotation tool for machine learning based myelin quantification
Authors: Çapar Abdulkerim , Çimen Sibel , Aladağ Zeynep , Ekinci Dursun Ali , Ayten Umut Engin , Kerman Bilal Ersen , Töreyin Behçet Uğur 
Published: April 2022

Myelin is an essential component of the nervous system and myelin damage causes demyelination diseases. Myelin is a sheet of oligodendrocyte membrane wrapped around the neuronal axon. In the fluorescent images, experts manually identify myelin by co-localization of oligodendrocyte and axonal membranes that fit certain shape and size criteria. Because myelin wriggles along x-y-z axes, machine learning is ideal for its segmentation. However, machine-learning methods, especially convolutional neural networks (CNNs), require a high number of annotated images, which necessitate expert labor. To facilitate myelin annotation, we developed a workflow and software for myelin ground truth extraction from multi-spectral fluorescent images. Additionally, to the best of our knowledge, for the first time, a set of annotated myelin ground truths for machine learning applications were shared with the community.
Control Inhibitorio y Regulación emocional: características, diferencias y desarrollo en la etapa preescolar
Authors: Donovan Clara 
Published: April 2022

El presente artículo de revisión bibliográfica investiga la relación entre los conceptos de regulación emocional y control inhibitorio destacando sus funciones y diferencias. A su vez, se mencionan sus características principales en la etapa preescolar. Se ha realizado una revisión exhaustiva y minuciosa sobre el tema en las principales fuentes de información y se ha llegado a la conclusión de que son constructos diferentes pero a su vez interdependientes. Mantienen una relación estrecha y recíproca compartiendo importantes puntos de desarrollo en común. El control inhibitorio es una de las principales funciones ejecutivas, junto con la memoria de trabajo y la flexibilidad cognitiva, y todas ellas se encuentran en la base de cualquier conducta organizada. Por otro lado, permiten el desarrollo de otras funciones más complejas como pueden ser el razonamiento, la planificación o la capacidad para resolver problemas. Estas habilidades de alto nivel cognitivo se desarrollan y evolucionan a lo largo de la vida manifestando un importante desarrollo en la etapa preescolar. Resultan imprescindibles para lograr una adaptación exitosa al ambiente, mantener una salud integral y están directamente vinculadas a la adquisición y desarrollo de las habilidades socioemocionales. En la infancia, tanto el control inhibitorio como la regulación emocional resultan fundamentales para obtener éxito académico y responder adecuadamente a las exigencias del entorno. El primero permite regular la atención, la cognición y el comportamiento mientras que la regulación emocional posibilita que las personas aprendan a regular la intensidad y la expresión de sus emociones. Ambos constructos están fuertemente vinculados con el desarrollo de competencias socioemocionales que promoverán interacciones sociales positivas y significativas. El control inhibitorio se encuentra en la base del proceso regulatorio de emociones y ambas habilidades tienen un importante desarrollo durante la etapa preescolar. Se pueden entrenar y, por lo tanto, se deben contemplar en las propuestas educativas.
Improved diagnostic performance of plain radiography for cervical ossification of the posterior longitudinal ligament using deep learning
Authors: Chae Hee-Dong , Hong Sung Hwan , Yeoh Hyun Jung , Kang Yeo Ryang , Lee Su Min , Kim Minyoung , Koh Seok Young , Lee Yongeun , Park Moo Sung , Choi Ja-Young , Yoo Hye Jin 
Published: April 2022

Background
A high false-negative rate has been reported for the diagnosis of ossification of the posterior longitudinal ligament (OPLL) using plain radiography. We investigated whether deep learning (DL) can improve the diagnostic performance of radiologists for cervical OPLL using plain radiographs.

Materials and methods
The training set consisted of 915 radiographs from 207 patients diagnosed with OPLL. For the test set, we used 200 lateral cervical radiographs from 100 patients with cervical OPLL and 100 patients without OPLL. An observer performance study was conducted over two reading sessions. In the first session, we compared the diagnostic performance of the DL-model and the six observers. The diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUC) at the vertebra and patient level. The sensitivity and specificity of the DL model and average observers were calculated in per-patient analysis. Subgroup analysis was performed according to the morphologic classification of OPLL. In the second session, observers evaluated the radiographs by referring to the results of the DL-model.

Results
In the vertebra-level analysis, the DL-model showed an AUC of 0.854, which was higher than the average AUC of observers (0.826), but the difference was not significant (p = 0.292). In the patient-level analysis, the performance of the DL-model had an AUC of 0.851, and the average AUC of observers was 0.841 (p = 0.739). The patient-level sensitivity and specificity were 91% and 69% in the DL model, and 83% and 68% for the average observers, respectively. Both the DL-model and observers showed decreases in overall performance in the segmental and circumscribed types. With knowledge of the results of the DL-model, the average AUC of observers increased to 0.893 (p = 0.001) at the vertebra level and 0.911 (p < 0.001) at the patient level. In the subgroup analysis, the improvement was largest in segmental-type (AUC difference 0.087; p = 0.002).

Conclusions
The DL-based OPLL detection model can significantly improve the diagnostic performance of radiologists on cervical radiographs.
Facilitating the Development of Clinical Competence in a Low-Resource Setting: Perceptions and Challenges of Nurse Educators
Authors: Salifu David Abdulai , Heymans Yolande , Christmals Christmal Dela 
Published: April 2022

Background: The inability of nursing education institutions, particularly in low-resource settings to train competent nurses has been partly attributed to the challenges faced by nurse educators in the teaching of practical skills and in facilitating the development of clinical competence. Unfortunately, the perceptions and challenges faced by nurse educators in clinical nursing educationin diploma nursing education in low-resource settings have not been explored.Purpose: This study aimed to explore and describe the perceptions and challenges of nurse educators in the teaching of practical skills and in facilitating the development of clinical competence in diploma nursing education in Ghana, a low-resource setting. Methods: A qualitative descriptive design was used in this study. Nine nurse educators tasked with teaching practical skills and facilitating the development of clinical competence from three accredited diploma-awarding public nursing colleges – one in each of the three geographical zones of Ghana – were purposively sampled and interviewed using a semi-structured interview guide. The data were analysed with the aid of ATLAS.ti software through the thematic framework approach of qualitative data analysis.Results: Four themes, namely nurse educator and student factors, skills learning environment factors, institutional challenges, and regulatory issues, were identified and described the challenges of practical skills teaching and clinical competence development confronting nurse educators in the study setting.Conclusion: To address these challenges, policy measures should be implemented to ensure adequate national investment in nursing education and incentives to promote nurse educator development and performance. Nurse educators and their labour union should therefore strongly advocate for this transformation in nursing education.
Impact of ultra-low temperature long-term storage on the preanalytical variability of twenty-one common biochemical analytes
Authors: Alegre Estibaliz , Varo Nerea , Fernández-Calle Pilar , Calleja Sofía , González Álvaro 
Published: April 2022

Abstract

Objectives
Retrospective studies frequently assume analytes long-term stability at ultra-low temperatures. However, these storage conditions, common among biobanks and research, may increase the preanalytical variability, adding a potential uncertainty to the measurements. This study is aimed to evaluate long-term storage stability of different analytes at <−70 °C and to assess its impact on the reference change value formula.

Methods
Twenty-one analytes commonly measured in clinical laboratories were quantified in 60 serum samples. Samples were immediately aliquoted and frozen at <−70 °C, and reanalyzed after 11 ± 3.9 years of storage. A change in concentration after storage was considered relevant if the percent deviation from the baseline measurement was significant and higher than the analytical performance specifications.

Results
Preanalytical variability (CVP) due to storage, determined by the percentage deviation, showed a noticeable dispersion. Changes were relevant for alanine aminotransferase, creatinine, glucose, magnesium, potassium, sodium, total bilirubin and urate. No significant differences were found in aspartate aminotransferase, calcium, carcinoembryonic antigen, cholesterol, C-reactive protein, direct bilirubin, free thryroxine, gamma-glutamyltransferase, lactate dehydrogenase, prostate-specific antigen, triglycerides, thyrotropin, and urea. As nonnegligible, CVP must remain included in reference change value formula, which was modified to consider whether one or two samples were frozen.

Conclusions
After long-term storage at ultra-low temperatures, there was a significant variation in some analytes that should be considered. We propose that reference change value formula should include the CVP when analyzing samples stored in these conditions.
Is thyroglobulin a reliable biomarker of differentiated thyroid cancer in patients treated by lobectomy? A systematic review and meta-analysis
Authors: Giovanella Luca , Ceriani Luca , Garo Maria Luisa 
Published: April 2022

Abstract

Objectives
The prognostic role of thyroglobulin in predicting recurrence in differentiated thyroid cancer (DTC) patients treated by lobectomy is controversial. This systematic review with meta-analysis aimed to update the current evidence deepening the reliability of circulating thyroglobulin in assessing the early response and in predictive recurrence.

Methods
The methodology was registered in the PROSPERO database under the protocol number CRD42021288189. A systematic search was carried out on PubMed, Embase, Web of Science, and Scopus from September to November 2021 without time and language restrictions. The literature search strategy was based on the following keywords: Thyroglobulin AND (Lobectomy OR Hemithyroidectomy).

Results
After screening 273 articles, seven studies were included in the systematic review, and only six of them were included in the meta-analysis for a total of 2,455 patients. Circulating thyroglobulin was found non-reliable in assessing early response and predicting recurrence in patients with hemithyroidectomy, especially those with a low initial ATA classification.

Conclusions
Our study does not support serum thyroglobulin levels for monitoring patients with low-risk DTC treated with lobectomy, and weak evidence supports its role for intermediate- or high-risk patients. Studies with longer follow-up, different study designs, and stringent inclusion/exclusion criteria are needed to evaluate the role of thyroglobulin in recurrence prediction.
Skein lasagna modules for 2-handlebodies
Authors: Manolescu Ciprian , Neithalath Ikshu 
Published: April 2022

Abstract
Morrison, Walker, and Wedrich used the blob complex to construct a generalization of Khovanov–Rozansky homology to links in the boundary of a 4-manifold. The degree zero part of their theory, called the skein lasagna module, admits an elementary definition in terms of certain diagrams in the 4-manifold. We give a description of the skein lasagna module for 4-manifolds without 1- and 3-handles, and present some explicit calculations for disk bundles over

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.