bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic lethal targeting ofTET2-mutant hematopoietic stem and progenitor cells by XPO1 inhibitors
Authors: Jing Chang-Bin , Prutsch Nicole , He Shuning , Zimmerman Mark W. , Landesman Yosef , Look A. Thomas 
Published: October 2022

AbstractTET2inactivating mutations serve as initiating genetic lesions in the transformation of hematopoietic stem and progenitor cells (HSPCs). In this study, we analyzed known drugs in zebrafish embryos for their abilities to selectively killtet2-mutant HSPCsin vivo, and we found that the exportin 1 (XPO1) inhibitors, selinexor and eltanexor, selectively killtet2-mutant HSPCs. In serial replating colony assays, these small molecules were selectively active in killing murineTet2-deficient Lineage-, Sca1+, Kit+ (LSK) cells, and alsoTET2-inactivated human acute myeloid leukemia (AML) cells. Selective killing ofTET2-mutant HSPCs and human AML cells by these inhibitors was due to increased levels of apoptosis, without evidence of DNA damage based on increased γH2AX expression. The finding thatTET2loss renders HSPCs and AML cells selectively susceptible to cell death induced by XPO1 inhibitors provides preclinical evidence of selective activity of these drugs, justifying further clinical studies of these small molecules for the treatment ofTET2-mutant hematopoietic malignancies and to suppress clonal expansion in age-relatedTET2-mutant clonal hematopoiesis.
METTL7A and METTL7B are responsible forS-thiol methyl transferase activity in liver
Authors: Russell Drake A. , Chau Marvin K. , Shi Yuanyuan , Maldonato Benjamin J. , Totah Rheem A. 
Published: October 2022

AbstractS-Methylation of drugs containing thiol-moieties often alters their activity and results in detoxification. Historically, scientists attributed methylation of exogenous aliphatic and phenolic thiols to a putativeS-adenosyl-L-methionine dependent membrane-associated phase II enzyme known as thiol methyltransferase (TMT). TMT has a broad substrate specificity and methylates the thiol metabolite of spironolactone, mertansine, ziprasidone, captopril, and the active metabolites of the thienopyridine pro-drugs, clopidogrel, and prasugrel. Despite TMT’s role in theS-methylation of clinically relevant drugs, the enzyme(s) responsible for this activity remained unknown. We recently identified methyltransferase-like protein 7B (METTL7B) as an alkyl thiol-methyltransferase. METTL7B is an endoplasmic-reticulum-associated protein with similar biochemical properties and substrate specificity to TMT. Yet, the historic TMT inhibitor, 2,3-dichloro-α-methylbenzylamine (DCMB), has no effect on the activity of METTL7B, indicating that multiple enzymes contribute to TMT activity. Here we report that methyltransferase-like protein 7A (METTL7A), an uncharacterized member of the METTL7 family, also acts as a thiolmethyltransferase. METTL7A exhibits similar biochemical properties to TMT, including inhibition by DCMB (IC50 1.2 µM). Applying quantitative proteomics to human liver microsomes and gene modulation experiments in HepG2 and HeLa cells, we determined that TMT activity correlates closely with METTL7A and METTL7B protein levels. Furthermore, purification of a novel His-GST-tagged recombinant protein and subsequent activity experiments prove that METTL7A can selectively methylate exogenous thiol-containing substrates, including 7α-thiospironolactone, dithiothreitol, 4-chlorothiophenol, and mertansine. We conclude that the METTL7 family encodes for two enzymes, METTL7A and METTL7B, which we have renamed TMT1A1 and TMT1B1, respectively, that are responsible for TMT activity in liver microsomes.Significance StatementWe identified METTL7A (TMT1A1) and METTL7B (TMT1B1) as the enzymes responsible for the microsomal alkyl thiol methyltransferase activity. These are the first two enzymes directly associated with microsomal TMT activity.S-Methylation of many commonly prescribed thiol-containing drugs alters their pharmacological activity and/or toxicity, and identifying the enzymes responsible, will improve our understanding of the DMPK properties of alkyl- or phenolic-thiol-containing therapeutics.Visual Abstract
Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells
Authors: Jimenez Lizandra , Stolzenbach Victor , Ozawa Patricia M. M. , Ramirez-Solano Marisol , Liu Qi , Sage Julien , Weaver Alissa M. 
Published: October 2022

AbstractSmall Cell Lung Cancer (SCLC) tumors are made up of distinct cell subpopulations, including neuroendocrine (NE) and non-NE cells. While secreted factors from non-NE SCLC cells have been shown to support the growth of the NE cells, the underlying molecular factors are not well understood. Here, we show that exosome-type small extracellular vesicles (SEVs) secreted from non-NE SCLC cells promote adhesion and survival of NE SCLC cells. Proteomic analysis of purified small EVs revealed that extracellular matrix (ECM) proteins and integrins are highly enriched in small EVs of non-NE cells whereas nucleic acid-binding proteins are enriched in small EVs purified from NE cells. Addition of select purified ECM proteins identified in purified EVs, specifically fibronectin, laminin 411, and laminin 511, were able to substitute for the role of non-NE-derived SEVs in promoting adhesion, survival, and tumorigenicity of NE SCLC cells. Those same proteins were differentially expressed by human SCLC subtypes. These data suggest that ECM-carrying SEVs secreted by non-NE cells play a key role in supporting SCLC tumor growth and survival.
Concurrent temporal patterning of neural stem cells in the fly visual system
Authors: Arain Urfa , Islam Ishrat Maliha , Valentino Priscilla , Erclik Ted 
Published: October 2022

AbstractThe temporal and spatial patterning of neural stem cells is a powerful mechanism by which to generate neural diversity in both vertebrate and invertebrate brains. In theDrosophilaoptic lobe, the neuroblasts (NBs) that generate the ∼120 neuronal cell types of the medulla are patterned by independent temporal and spatial inputs. In the temporal axis, a cascade of twelve transcription factors (TFs) are expressed in medulla NBs as they age. In the spatial axis, the neuroepithelium from which these NBs are generated is sub-divided into eight compartments by the expression of five additional TFs. Distinct neuronal types are generated by NBs based on their spatio-temporal address. Here, we describe a third major patterning axis that further diversifies neuronal fates in the medulla. We show that the symmetrically dividing neuroepithelial cells from which the medulla NBs are generated are temporally patterned by opposing gradients of the Imp and Syp RNA-binding proteins. Imp and Syp regulate the expression of a set of TFs in the neuroepithelium to confer NBs from the same spatio-temporal address with unique identities based on the developmental stage they are generated. We show that Imp and Syp differentially pattern NBs in the Vsx1-Hth spatio-temporal birth window to generate seven distinct neuronal cell types (Li2, TmY17, TmY15, Tm23, Pm3a, Pm3b and TmY12) in successive developmental windows. We further demonstrate that the birthdate of these neurons correlates with their final position in the adult cortex, resulting in unanticipated specializations of the retinotopic circuit in the anterior-posterior axis of the visual system. The concurrent temporal patterning of symmetrically and asymmetrically dividing neural stem cells thus acts as a powerful mechanism to couple the generation of neural diversity with circuit patterning.
Social support and risk-taking propensity as predictors of entrepreneurial intention among undergraduates in Nigeria
Authors: Ilevbare Femi Monday , Ilevbare Oluwatosin Eniola , Adelowo Caleb Muyiwa , Oshorenua Favour P. 
Published: October 2022

Purpose
This paper aims to examine the determinants of entrepreneurial intention among students of a university in Nigeria, with particular emphasis on their risk-taking propensity, social support and demographic variables.

Design/methodology/approach
Data for the study were collected from 350 undergraduates across seven faculties in Obafemi Awolowo University, Nigeria, through a self-reported questionnaire. Descriptive and regression statistical analysis were used to estimate and test the relationship among entrepreneurial intention and social support, risk-taking propensity and demographic variables.

Findings
The results showed high entrepreneurial intention among the students. The push factors, such as perceived social support from families, risk-taking propensity and previous engagement in business, are key determinants of entrepreneurship intention among the students. The age and father’s occupation also showed a significant relationship with the level of entrepreneurial intention.

Practical implications
This result suggests that strengthening social support for entrepreneurship among students could enhance their desire to own a business during and after graduation. Improving entrepreneurship ecosystems in the university could further motivate those already practicing entrepreneurship while also stimulating intentions among others. For instance, provision of entrepreneurship infrastructure and incentives such as business incubators, innovation hubs, science parks and competitive business grants could enhance the risk-taking propensity among students and motivate them for venture creation.

Originality/value
Understanding the influence of social support and risk-taking propensity on entrepreneurial intention among undergraduates is important for policy and practice. The result further reinforces the need to promote entrepreneurship education to create a critical mass of potential entrepreneurs in the university.
Change and innovation in food aid provision in Sussex and Southwest London during the COVID-19 pandemic
Authors: Ranta Ronald , Mulrooney Hilda Mary , Bhakta Dee 
Published: October 2022

PurposeThe purpose of this paper is to examine how food aid providers in Sussex and Southwest London responded and managed during the pandemic.Design/methodology/approachThe methodological approach consists of three inter-related layers. A qualitative description research approach based on naturalistic inquiry, supplemented by site visits and personal observations was used.FindingsThe pandemic catalysed dramatic, often positive, changes to the provision of food aid, with a move away from the traditional food bank model. It brought about increased coordination and oversight, as well as the upscaling of capabilities, infrastructure and provisions.Originality/valueThe paper contributes to the literature on food aid in the UK It provides evidence for how providers are transforming the sector for the better and potentially helping to deal with the cost-of-living crisis.
The effect of service failure severity on brand forgiveness: the moderating role of interpersonal attachment styles and thinking styles
Authors: Alnawas Ibrahim , Al Khateeb Amr , Abu Farha Allam , Ndubisi Nelson Oly 
Published: October 2022

Purpose
The purpose of this study is to examine the effect of service failure severity on brand forgiveness and to investigate the moderating effects of interpersonal attachment styles and thinking styles on the service failure severity–brand forgiveness relationship.

Design/methodology/approach
The authors used retrospective experience sampling to collect the data and structural equation modeling (AMOS 24) to analyze 570 responses collected via an online survey.

Findings
This study shows that the service failure severity–brand forgiveness relationship is not always negative, as different conditions may amplify or weaken it. Specifically, a secure attachment style and holistic thinking weaken the negative impact of service failure severity on brand forgiveness, whereas an anxious attachment style and analytic thinking negatively amplify the relationship. An avoidance attachment style did not appear to play a role.

Practical implications
This study should help hotels fine-tune their segmentation, targeting and positioning efforts and may also help in implementing more focused recovery strategies.

Originality/value
This study provides insights into the role of psychological traits in amplifying/reducing the negative impact of service failure severity on brand forgiveness, thus showing the importance of developing the psychological profiles of customers beyond demographic profiling. The emotional and cognitive typologies of consumers are key to understanding the dependence of forgiveness on service failure severity.
Model comparison in German stock returns
Authors: O'Connell Michael 
Published: October 2022

PurposeIn order to provide an updated view on the drivers of German stock returns, the authors evaluate the relative performance of nine competing neoclassical asset pricing models in the German stock market between November 1991 and December 2021.Design/methodology/approachThe authors conduct asymptotically valid tests of model comparison when the extent of model mispricing is gauged by the squared Sharpe ratio improvement measure of Barillas et al. (2020).FindingsThe study finds that the Fama and French six-factor model with both traditional and updated value factors emerges as the dominant model.Originality/valueThe authors shed new light on the drivers of German stock returns through an updated and extended period of analysis, wider range of potential models and utilization of valid asymptotic tests of model comparison when models are nonnested (Barillas et al., 2020).
Material sustainability information and reporting standards. Exploring the differences between GRI and SASB
Authors: Pizzi Simone , Principale Salvatore , de Nuccio Elbano 
Published: October 2022

Purpose
This paper aims to contribute to the emerging debate on materiality with novel and original insights about the managerial and theoretical implications related to the adoption of the Global Reporting Initiative (GRI) and the Sustainability Accounting Standards Board (SASB) as reporting standards. Furthermore, the paper will evaluate the main drivers that favor the combination of the two standards by companies to develop new knowledge about the hierarchical relationship between financial and sustainability materiality.

Design/methodology/approach
Building on a sample of 2,046 US listed companies observed during the period 2017–2020, the research is conducted using quantitative methods. Multinomial logistic regressions are used to evaluate the differences between GRI and SASB’s adoption.

Findings
The analysis highlights that financial and sustainability materiality are driven by different purposes. In detail, SASB’s adoption is driven by factors directly related to financial dynamics, while GRI’s adoption is influenced by the existence of corporate governance mechanisms inspired by sustainable and ethical principles. Furthermore, the last analysis reveals that the combination of the two standards is characterized by the predominance of sustainability materiality.

Originality/value
To the best of the authors’ knowledge, this is the first empirical study on the relationship between financial and sustainability materiality.
Work-from-home (WFH): the constraints–coping–effectiveness framework
Authors: Ahmad Zauwiyah , Asmawi Arnifa , Samsi Siti Zakiah Melatu 
Published: October 2022

PurposeWork-from-home (WFH) arrangement is implemented to enable employees to achieve work–life balance. However, WFH arrangement can be less than ideal. This study developed a WFH framework using qualitative data.Design/methodology/approachAn open-ended survey was conducted and participated by 621 employees. The data were examined using the qualitative content analysis method.FindingsWork performance and personal well-being have been identified as WFH outcomes, and 12 relevant research propositions have been developed. Constraints to WFH effectiveness include household and organisational factors whilst instrumental and emotional support were identified as the facilitating conditions. Two moderators were also identified: temporal flexibility and commitment orientation.Research limitations/implicationsThis study provides a framework that support effective implementation of WFH and similar flexible work arrangements. Managing time, situation, emotions and attitudes are coping strategies used by WFH employees, and the efficacy of these strategies needs further empirical investigation.Practical implicationsThree main factors have been identified as significant in determining WFH effectiveness. Understanding these elements can help managers design solutions to help employees manage work-home boundaries, improving their work performance and well-being.Originality/valueThe Constraints–Coping–Effectiveness WFH framework and research propositions help organisations build WFH guidelines and policies. This study also recognises commitment orientation, which links resources, strategies and outcomes. The inclusion of this variable in future empirical studies could explain the gaps in the current literature.
IC solder joint inspection via adaptive statistical modeling
Authors: Xiao Meng , Cai Nian , Mo Zhuokun , Yan Shule , Tian Nili , Ma Jing , Wang Han 
Published: October 2022

Purpose
Statistical modeling has been successfully applied to integrated circuit (IC) solder joint inspection. However, there are some inherent problems in previous statistical modeling methods. This paper aims to propose an adaptive statistical modeling method to further improve the inspection performance for IC solder joints.

Design/methodology/approach
First, different pixels in the IC solder joint image were modeled by different templates, each of which was composed of the hue value of the pixel and a proposed template significance factor. Then, the potential defect image was obtained by adaptive template matching and the potential defect threshold for each pixel. It was noted that the number of templates, matching distance threshold, potential defect threshold and updating rate were adaptively updated during model training. Finally, the trained statistical model was used to inspect the IC solder joints by means of defect degree.

Findings
Experimental results indicated that the proposed adaptive schemes greatly contributed to the inspection performance of statistical modeling. Also, the proposed inspection method achieved better performance compared with some state-of-the-art inspection methods.

Originality/value
The proposed method offers a promising approach for IC solder joint inspection, which establishes different numbers of templates constructed by pixel values and template significance factors for different pixels. Also, some important parameters were adaptively updated with the updating of the model, which contributed to the inspection performance of the model.
Do young women travellers really consider the risk of sexual harassment during night travel? Evening travel vs midnight travel
Authors: Wang Xin , Lai Ivan Ka Wai , Wang Kun 
Published: October 2022

Purpose
This study aims to examine the influence of benefits and risks for young women travellers on their intention to visit other night tourism destinations. It also compares any path differences between evening and midnight travels.

Design/methodology/approach
A face-to-face survey was conducted in Macau. Multi-group analysis was used to explore the differences between evening and midnight travels.

Findings
Emotional and epistemic benefits positively affect behavioural intentions; security risk negatively affects behavioural intentions, but the risk of sexual harassment does not affect behavioural intentions. Evening travellers pay more attention to emotional benefits than midnight travellers.

Originality/value
This study contributes to tourism research related to women by helping to understand the perceptions of the benefits and risks of young women travellers’ night tourism, especially the gender risks. This study corrects the understanding that young women travellers do not feel that the risk of sexual harassment affects their decision to undertake night travels. It also contributes to night tourism research by distinguishing the proportion of benefits and risks in evening and midnight travels.
Antimicrobial peptide HI‐3 from Hermetia illucens alleviates inflammation in lipopolysaccharide‐stimulated RAW264.7 cells via suppression of the nuclear factor kappa‐B signaling pathway
Authors: Xiaoyan Xu , Hongxia Sun , Jiamin Gao , Huicheng Cui , Ye Liao , Qiang Xia 
Published: October 2022

AbstractHermetia illucens‐3 (HI‐3), an active insect antimicrobial peptide extracted from H. illucens larvae, exerts antibacterial and anticancer activity. However, the inflammatory effects and their relative molecular mechanisms remain unclear. To explore the inflammatory effects of HI‐3, an inflammatory model was induced using 1 ng/mL LPS in RAW264.7 cells. The cell viability and phagocytosis of LPS‐stimulated RAW264.7 cells were then detected after HI‐3 treatment. Furthermore, the antioxidant activity, the levels of proinflammatory cytokines, and the expression levels of both p65 and inhibitor of nuclear factor kappa B (IκB) were measured. Results showed that HI‐3 could inhibit the differentiation, proliferation, phagocytosis, and antioxidant ability, as well as the secretion and messenger RNA expression levels of IL‐6, TNF‐α, and IL‐1β of LPS‐induced RAW264.7 cells in a dose‐dependent manner. At the same time, the level of the anti‐inflammatory cytokine IL‐10 was increased after HI‐3 treatment. Western blotting results showed that HI‐3 suppressed LPS‐induced p65 and IκB activation in a dose‐dependent manner. Therefore, HI‐3 exerts its anti‐inflammatory effect by inhibiting the expression of proinflammatory cytokines and the activation of p65 and IκB, which indicated that HI‐3 could be a promising therapeutic medicine for inflammation.
Biological Flora of Britain and Ireland:Corylus avellana
Authors: Hicks Damien 
Published: October 2022

AbstractThis account presents information on all aspects of the biology ofCorylus avellanaL. (Hazel) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of theBiological Flora of Britain and Ireland: distribution, habitat, communities, responses to biotic factors, responses to environment, structure and physiology, phenology, floral and seed characters, herbivores and disease, history and conservation.WildC. avellanain Britain and Ireland grows in a wide climatic and ecological range, in a broad suite of vegetation communities, particularly woodlands, at all latitudes and from 0 to 650 m asl. It supports a large number of faunal and fungal associates. The developing plant sends up basal shoots every spring from the peripheral parts of its underground stool, which gives it a structural regenerative advantage over cohabitant woody species.The flowers and pollen ofC. avellanaare adapted for wind pollination, yet honeybees have been observed to gather its pollen. The pollen and fruit ofC. avellanaare a cause of allergic reactions in sensitive people, with previous exposure to Birch pollen a strong predictor of the food allergy.Corylus avellanais native to Europe and western Asia, and was one of the first plant species to recolonize Europe after the last gIacial period. By the time of its cultivation in the Roman empire, regional human‐selected lineages ofC. avellanawere already developing, with independent domestication in the western and eastern Mediterranean.Corylus avellanais a genetically diverse taxon with effective gene flow across populations, presenting a continuum of wild to domesticated plants. Its nuts and involucres show a wide morphological variability, with hundreds of cultivars and forms proposed. The taxonCorylus maximaMill. is sympatric and fully fertile withC. avellana, yet rarely self‐sown and their hybrid is little recorded in Britain and Ireland. Independent molecular studies have concluded that specimens ofC. maximacluster withC. avellana.Hazelnuts are globally one of the most important nut crops, currently with 70% of traded nuts being grown in Türkiye, followed by Italy and Azerbaijan.