bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice
Authors: Igarashi Tsutomu , Ohsawa Ikuroh , Kobayashi Maika , Miyazaki Kai , Igarashi Toru , Kameya Shuhei , Shiozawa Asaka Lee , Ikeda Yasuhiro , Miyagawa Yoshitaka , Sakai Mashito , Okada Takashi , Sakane Iwao , Takahashi Hiroshi 
Published: August 2022

AbstractRetinitis pigmentosa (RP) is a genetically heterogeneous group of inherited retinal disorders involving the progressive dysfunction of photoreceptors and the retinal pigment epithelium, for which there is currently no treatment. The rd6 mouse is a natural model of autosomal recessive retinal degeneration. Given the known contributions of oxidative stress caused by reactive oxygen species (ROS) and selective inhibition of potent ROS peroxynitrite and OH·by H2 gas we have previously demonstrated, we hypothesized that ingestion of H2 water may delay the progression of photoreceptor death in rd6 mice. H2 mice showed significantly higher retinal thickness as compared to controls on optical coherence tomography. Histopathological and morphometric analyses revealed higher thickness of the outer nuclear layer for H2 mice than controls, as well as higher counts of opsin red/green-positive cells. RNA sequencing (RNA-seq) analysis of differentially expressed genes in the H2 group versus control group revealed 1996 genes with significantly different expressions. Gene and pathway ontology analysis showed substantial upregulation of genes responsible for phototransduction in H2 mice. Our results show that drinking water high in H2 (1.2–1.6 ppm) had neuroprotective effects and inhibited photoreceptor death in mice, and suggest the potential of H2 for the treatment of RP.
Research on collapse ultimate load of fabricated reinforced concrete column and steel beam composite frame structure
Authors: Liu Youquan , Xiong Jingang , Wen Jiancong , Xiong Moqiang 
Published: August 2022

AbstractIn this work, the collapse ultimate load of a prefabricated reinforced concrete column–steel beam composite frame structure was studied. During the study, the “new RCS beam-to-column joint” was used as the beam-to-column connection in the experimental model. Further, the half-scale fabricated RCS space frame structure (2-story, 1 × 2 bay) was subjected to instantaneous failure experiments twice at the bottom of the side column under various load levels and the 2A column was quickly pulled out by the traction force of the vehicle. The experimental results demonstrated that the method of dismantling the failure column provided a relatively true response to the condition of progressive collapse. The remaining RCS structure was found to be in the elastic stage during various load level tests. Moreover, the displacement time history curve did not have a vibration phenomenon during the first experimentation. The SAP2000 finite element program was used to verify that the test results were similar to that of the numerical simulation results, and it was further explored and found that the collapse ultimate load value was 10.25 times the structure design load value.
Synthesis of vacant graphitic carbon nitride in argon atmosphere and its utilization for photocatalytic hydrogen generation
Authors: Praus Petr , Řeháčková Lenka , Čížek Jakub , Smýkalová Aneta , Koštejn Martin , Pavlovský Jiří , Filip Edelmannová Miroslava , Kočí Kamila 
Published: August 2022

AbstractGraphitic carbon nitride (C3N4) was synthesised from melamine at 550 °C for 4 h in the argon atmosphere and then was reheated for 1–3 h at 500 °C in argon. Two band gaps of 2.04 eV and 2.47 eV were observed in all the synthetized materials. Based on the results of elemental and photoluminescence analyses, the lower band gap was found to be caused by the formation of vacancies. Specific surface areas of the synthetized materials were 15–18 m2g−1 indicating that no thermal exfoliation occurred. The photocatalytic activity of these materials was tested for hydrogen generation. The best photocatalyst showed 3 times higher performance (1547 μmol/g) than bulk C3N4 synthetized in the air (547 μmol/g). This higher activity was explained by the presence of carbon (VC) and nitrogen (VN) vacancies grouped in their big complexes 2VC + 2VN (observed by positron annihilation spectroscopy). The effect of an inert gas on the synthesis of C3N4 was demonstrated using Graham´s law of ammonia diffusion. This study showed that the synthesis of C3N4 from nitrogen-rich precursors in the argon atmosphere led to the formation of vacancy complexes beneficial for hydrogen generation, which was not referred so far.
Longitudinal association of atopic dermatitis progression and keratin 6A
Authors: Zhu Angela Y. , Mitra Nandita , Margolis David J. 
Published: August 2022

AbstractAtopic dermatitis is a common skin disease characterized by loss of skin integrity. Risk and severity have been associated with genetic variation especially with respect to the filaggrin gene, suggesting the importance of skin barrier function in atopic dermatitis pathogenesis. The keratin protein plays a role in epithelial health but its relationship with disease severity would benefit from further exploration. In this study, we evaluate the association between common keratin 6 variants and severity of atopic dermatitis over time using a Bayesian generalized linear mixed model to account for repeated measures. We identify groups of variants within which individual variants have similar effects on skin repair. Further assessment of the biological mechanisms by which these contribute to repair of epidermis may inform treatment of atopic dermatitis.
Effectiveness of splitter plate to control fluid forces on a circular obstacle in a transient flow: FEM computations
Authors: Ain Qurrat ul , Mahmood Rashid , Awrejcewicz Jan , Siddique Imran , Majeed Afraz Hussain , Pawłowski Witold 
Published: August 2022

AbstractThe reliability of the usage of a splitter plate (passive control device) downstream of the obstacle, in suppressing the fluid forces on a circular obstacle of diameter$$D = 0.1\;\;{\text{m}}$$D=0.1mis studied in this paper. The first parameter of the current study is the attachment of a splitter plate of various lengths$$(L_{i} )$$(Li)with the obstacle, whereas the gap separation$$(G_{i} )$$(Gi)between the splitter plate and the obstacle, is used as a second parameter. The control elements of the first and second parameters are varied from$$0.1$$0.1to$$0.3$$0.3. For the attached splitter plates of lengths$$0.2$$0.2and$$0.3$$0.3, the oscillatory behavior of transient flow at$$Re = 100$$Re=100is successfully controlled. For the gap separation,$$0.1$$0.1and$$0.2$$0.2similar results are obtained. However, it is observed that a splitter plate of too short length and a plate located at the inappropriate gap from the obstacle, are worthless. A computational strategy based on the finite element method is utilized due to the complicated representative equations. For a clear physical depiction of the problem, velocity and pressure plots have been provided. Drag and lift coefficients the hydrodynamic benchmark values are also evaluated in a graphical representation surrounding the obstacle’s peripheral surface as well as the splitter plate. In a conclusion, a splitter plate can function to control fluid forces whether it is attached or detached, based on plate length and gap separation between obstacle and plate, respectively.
Clinical staging and genetic profiling of Korean patients with primary lymphedema using targeted gene sequencing
Authors: Seo Soo Hyun , Lee Seungjun , Park Joseph Kyu-hyung , Yang Eun Joo , Kim Boram , Lee Jee-Soo , Kim Man Jin , Park Sung Sup , Seong Moon-Woo , Nam Sun-Young , Heo Chan-Yeong , Myung Yujin 
Published: August 2022

AbstractLymphedema is a progressive disease caused by lymphatic flow blockage in the lymphatic pathway. Primary (hereditary) lymphedema is caused by genetic mutations without secondary causes. We performed clinical profiling on Korean primary lymphedema patients based on their phenotypes using lymphoscintigraphy and made genetic diagnoses using a next-generation sequencing panel consisting of 60 genes known to be related to primary lymphedema and vascular anomalies. Of 27 patients included in this study, 14.8% of the patients had lymphedema of the upper extremities, 77.8% had lymphedema of the lower extremities and 7.4% had 4-limbs lymphedema. Based on the International Society of Lymphology staging, 14, 10, and 3 patients had stage 3, 2, and 1 lymphedema, respectively. Only one family was genetically confirmed to harbor likely pathogenic variants in CELSR1. The proband was carrying two likely pathogenic variants in CELSR1, while her symptomatic mother was confirmed to carry only one of the variants. Furthermore, two other variants of uncertain significance in CELSR1 were detected in other patients, making CELSR1 the most commonly altered gene in our study. The clinical and genetic profile of hereditary lymphedema reported here is the first such data series reported for South Korea.
A non-invasive system to monitor in vivo neural graft activity after spinal cord injury
Authors: Ago Kentaro , Nagoshi Narihito , Imaizumi Kent , Kitagawa Takahiro , Kawai Momotaro , Kajikawa Keita , Shibata Reo , Kamata Yasuhiro , Kojima Kota , Shinozaki Munehisa , Kondo Takahiro , Iwano Satoshi , Miyawaki Atsushi , Ohtsuka Masanari , Bito Haruhiko , Kobayashi Kenta , Shibata Shinsuke , Shindo Tomoko , Kohyama Jun , Matsumoto Morio , Nakamura Masaya , Okano Hideyuki 
Published: August 2022

AbstractExpectations for neural stem/progenitor cell (NS/PC) transplantation as a treatment for spinal cord injury (SCI) are increasing. However, whether and how grafted cells are incorporated into the host neural circuit and contribute to motor function recovery remain unknown. The aim of this project was to establish a novel non-invasive in vivo imaging system to visualize the activity of neural grafts by which we can simultaneously demonstrate the circuit-level integration between the graft and host and the contribution of graft neuronal activity to host behaviour. We introduced Akaluc, a newly engineered luciferase, under the control of enhanced synaptic activity-responsive element (E-SARE), a potent neuronal activity-dependent synthetic promoter, into NS/PCs and engrafted the cells into SCI model mice. Through the use of this system, we found that the activity of grafted cells was integrated with host behaviour and driven by host neural circuit inputs. This non-invasive system is expected to help elucidate the therapeutic mechanism of cell transplantation treatment for SCI.
Reading Skills in Children With Suspected Childhood Apraxia of Speech and Children With Reading Disorders: Same or Different?
Authors: Miller Gabrielle J. , Lewis Barbara A. 
Published: August 2022

Purpose:
The primary aim of this study was to compare decoding and literacy-related skills of children with suspected childhood apraxia of speech (sCAS) to children with reading disorders (RD) and no history of speech sound disorder (RD-no SSD) to determine if the groups differ in decoding and the endophenotypes that contribute to RD. We also explored the association between language impairment (LI) and decoding and literacy-related skills within the participant group with sCAS.

Method:

Participants were school-age children and adolescents, 8–14 years of age, with a diagnosis of sCAS (
n
= 13) or RD-no SSD (
n
= 16). The sCAS and RD-no SSD groups were compared on measures of single-word decoding, oral language, motor-speech skills, phonological processing, and speech-in-noise perception, employing
t
tests and analysis of covariance. The sCAS + LI and sCAS-only groups were compared on similar measures using
t
tests.

Results:
Compared to the RD-no SSD group, the sCAS group performed significantly worse on measures of phonological processing, multisyllable word repetition, diadochokinetic rate, and speech-in-noise perception. The groups did not differ on measures of single-word decoding, with mean scores for both groups falling below average. All participants with sCAS + LI demonstrated deficits in literacy and literacy-related skills compared to a smaller percentage of the sCAS-only group.

Conclusions:
Children with sCAS and children with RD-no SSD demonstrate similar impairments in literacy. However, the endophenotypes underlying these difficulties can differ between the groups. Deficits in skills needed for literacy may require specifically tailored interventions to address reading difficulties for children with sCAS, especially for those with comorbid LI.
Hybrid beamforming with impaired elements: Design of optimized beam pattern
Authors: Liu Jiawen , Li Xiaohui , Fan Tao , Lv Siting , Shi Mingli 
Published: August 2022

AbstractMillimeter‐wave (mmWave) multi‐input multi‐output systems, affected by atmospheric conditions and hardware failure, are vulnerable to antenna element blockages and failures. The authors consider the hybrid beamforming (HBF) optimization problem for systems with impaired elements to approximate the performance of a fault‐free system. Especially, the impaired coefficient of elements is estimated rather than simply assuming it is completely invalid. Firstly, to ensure that radiation power is within the desired angle, the impaired coefficients are estimated and the beamforming vector basis is designed. Then, by using the derived basis and semidefinite relaxation (SDR) technique, a minimax optimization problem is solved to smooth the passband response. Finally, a hybrid decomposition is conducted to be compatible with HBF structures. Numerical results indicate that the proposed algorithm improves the average data rate of the mmWave system with three impaired elements by about 40%, which is almost 93% of the performance of a fault‐free system.
Data‐driven model‐free adaptive attitude control for morphing vehicles
Authors: Che Haohui , Chen Jun , Wang Yonghai , Wang Jianying , Luo Yunhao 
Published: August 2022

AbstractThis paper investigates the attitude control problem of the morphing vehicle subject to great dynamics changes and disturbances during the morphing phase. An improved model‐free adaptive control (MFAC) method is proposed based on the compact format dynamic linearization technique. Firstly, a compact format data model and data‐driven control scheme are established based on the input/output (I/O) data of the controlled plant, independent of the complicated and time‐varying mathematical model of the morphing vehicle. Secondly, a series of historical output data errors in a moving time window are introduced to the control law, in which the length of the moving time window can be adjusted according to the system order of controlled plant. The convergence and stability of the improved control law are then proved theoretically, which guarantees the convergence of the tracking errors and the boundedness of the input and output data. Finally, numerical simulations are presented to evaluate the proposed approach, and comparisons are made with the conventional proportional‐derivative control method. Simulation results demonstrate that the improved method possesses better effectiveness and robustness in the presence of model changes and disturbances.
Optimal sizing and siting of different types of EV charging stations in a real distribution system environment
Authors: Sengor Ibrahim , Erenoglu Ayse Kubra , Guldorum Hilmi Cihan , Erdinc Ozan , Taşcıkaraoğlu Akın , Taştan İbrahim Can , Büyük Ali Fuat , Catalão João P. S. 
Published: August 2022

AbstractDue to the rising of both economic and environmental concerns in the energy sector, each subdivision of the community is investigating new solutions to overcome this critical issue. For this reason, electric vehicles (EVs) have gained more significance in the transportation sector owing to their efficient and clean operation chance. These improvements, however, bring new challenges such as installation costs, infrastructure renovation, and loading of the existing power system. Here, optimal sizing and siting of EV charging stations (CSs) are examined in a mixed‐integer linear programming framework with the aim of minimizing the number of EVCSs in the distribution system (which in turn means to minimize CS‐related investment while satisfying EV owners' needs) while satisfying constraints. The proposed optimization model considers EVCS types with different charging rate capabilities to provide opportunities for demand‐side management. Moreover, the model takes the actual behaviour of the battery charging pattern into account by using real measured EV charging data together with the consideration of an actual distribution system belonging to a region in Turkey. Lastly, a bunch of case studies is conducted in order to validate the accuracy and effectiveness of the devised model.
Oil palm (Elaeis guineensis Jacq.) genetic differences in mineral nutrition: potassium and magnesium effects on morphological characteristics of four oil palm progenies in Nigeria (West Africa)
Authors: Dassou Olivier Sènankpon , Bonneau Xavier , Aholoukpè Hervé , Vanhove Wouter , Ollivier Jean , Peprah Stephen , Flori Albert , Durand-Gasselin Tristan , Mensah Apollinaire Guy , Sinsin Brice Augustin , Van Damme Patrick 
Published: August 2022

We compared four oil palm (Elaeis guineensis Jacq.) progenies’ morphological growth characteristics to reveal genotypic differences in plant growth and assess their adaptability in Nigeria’s environment in response to different levels of potassium chloride (KCl) and kieserite fertilizer applications. The studied progenies (C1, C2 and C3 of Deli × La Mé origin and C4 of Deli × Yangambi origin) represent a wide genetic diversity of oil palm and have shown among a population of 116 different progenies, a contrasting K and Mg leaflet concentrations that covered the extreme ranges of leaflet concentrations in these minerals. The trial consisted of a completely randomized split-plot factorial design with six replicates, where progenies, considered as sub-factor were treated with combinations of 3 levels of potassium chloride (0, 1.5, 3.0 kg of KCl palm−1 year−1) and kieserite (0, 0.75, 1.5 kg of MgSO4 palm−1 year−1) fertilizers (main factor), respectively. Growth characteristics differed significantly among progenies, but not in all studied years. In all progenies, KCl treatments significantly increased the average annual collar girth increment and projected canopy area. Adding 3.0 kg palm−1 year−1 of KCl significantly increased the total leaf area of progeny C4. Kieserite applications did not have an effect on progenies’ growth characteristics whereas potassium showed to be the main mineral needed for oil palm growth. It was shown that with equal amounts of fertilizers applied, progeny C3 had better morphological traits than the other progenies, suggesting that the effective nutrient requirements should be assessed for each individual progeny and that fertilization should be adapted accordingly.
Phlebitis und Thrombose der Armvenen: Fallberichte aus der phlebologischen Sprechstunde
Authors: Recke Anna Lena 
Published: August 2022

ZusammenfassungPhlebitiden und Thrombosen der Armvenen sind in der phlebologischen Sprechstunde eher selten. In dieser Fortbildung in Bildern werden 3 unterschiedliche Fälle mit Phlebitis und/oder Thrombose der Armvenen vorgestellt und kommentiert.
Das pelvine Stauungssyndrom – Wie kann die Patientenversorgung mit der wissenschaftlich technischen Entwicklung Schritt halten?
Authors: Hirsch Tobias 
Published: August 2022

ZusammenfassungUnterleibsbeschwerden und atypische Varikose können Ausdruck eines pelvinen Stauungssyndroms sein. Die Erkrankung ist für Patientinnen häufig mit einer langwierigen Krankheitsgeschichte verbunden und stellt eine diagnostische und therapeutische Herausforderung für Phlebologen und Gefäßmediziner dar. Dabei stehen die technischen Möglichkeiten und auch die wissenschaftlichen Grundlagen eigentlich zur Verfügung.Ursachen sind die allgemeine Unterbewertung der Störung im ärztlichen Ausbildungskanon und das Fehlen einer flächendeckenden Versorgungsstruktur. Der ambulanten Abklärung sind versorgungsrechtliche Grenzen gesetzt und nur wenige Krankenhäuser verfügen über die entsprechende Behandlungsexpertise. Um diesem Versorgungsengpass entgegenzuwirken, wurde in der Deutschen Gesellschaft für Phlebologie der Beschluss gefasst, eine Arbeitsgemeinschaft ins Leben zu rufen, die drei Ziele verfolgt: die bundesweite Vernetzung ambulant tätiger Gefäßmediziner und spezialisierter Krankenhäuser, die Sensibilisierung anderen Fachrichtungen wie Gynäkologie und Urologie sowie die Datenerhebung im Rahmen eines Registers zur wissenschaftlichen Auswertung.
Patientenfaktoren in der Behandlung von Straftätern:
Persönlichkeit, Therapiemotivation und Outcome
Authors: Schorer Leila , Ross Thomas , Fontao Maria 
Published: August 2022

ZusammenfassungAnhand eines systematischen Literaturreviews nach den PRISMA-Kriterien wurden
Patientenfaktoren von Straftätern mit forensischen Outcomes in Bezug
gesetzt. Recherchiert wurde in den Datenbanken PsycInfo und PSYNDEX, weitere
relevante Studien wurden den Literaturverzeichnissen von Studien, die die
Selektionskriterien erfüllten, entnommen. Es wurden nur quantitative
empirische Studien für den Zeitraum 1990–2021 eingeschlossen.
Befunde aus 31 Arbeiten zu Patientenfaktoren (Persönlichkeit,
Therapiemotivation, Therapieerwartung, Zufriedenheit mit der Therapie) werden
referiert. Patientenfaktoren lassen sich nicht immer einheitlich mit Outcomes in
Verbindung bringen. Die deutlichsten Zusammenhänge ergaben sich zwischen
der Ausprägung anti- bzw. dissozialen Persönlichkeitsmerkmale
und/oder Psychopathy und (negativen) Therapieergebnissen. Merkmale, die
in der Regel mit antisozialen Entwicklungen assoziiert sind
(Impulsivität, Ärger, Wut, Feindseligkeit), korrelieren
teilweise ebenfalls negativ mit therapeutisch wünschenswerten
Ergebnissen. Die Therapiemotivation von Patienten dürfte sich im
Allgemeinen positiv auf die Wahrscheinlichkeit erfolgreicher forensischer
Therapien auswirken, aber nicht alle einschlägigen Studien weisen in
diese Richtung. Studien, die Therapieerwartung und Zufriedenheit im Zusammenhang
mit forensischen Outcomes untersuchen, wurden nicht identifiziert. In Anlehnung
an die allgemeine Psychotherapieforschung könnte die Therapie von
Straftätern von breiter angelegten Konzepten zur Untersuchung der
Therapiewirksamkeit profitieren.
Zuverlässigkeit der Elektroneuro-, myografie: Aspekte zur
neurologischen Begutachtung
Authors: Buchner Helmut , Ferbert Andreas 
Published: August 2022

ZusammenfassungVon einem Gutachten wird eine zuverlässige Bewertung erwartet. Aspekte
der Zuverlässigkeit der Elektroneuro-, myografie werden vorgestellt.
Ihre Bedeutung für die Begutachtung wird mit Blick auf Diagnostik und
das Ausmaß eines ggf. vorhandenen funktionellen Defizits besprochen.
Pudendale Varikosis – ein Überblick
Authors: Dietrich Andreas H. , Schießl Jasmin 
Published: August 2022

ZusammenfassungDie pudendale Varikosis ist eine medial der Adduktorenkanäle gelegene Varikosis. Häufig ist ein Auftreten in der Schwangerschaft mit überwiegend spontaner Regression postpartal. Meist besteht ein asymptomatischer Verlauf, in wenigen Fällen können aber auch Druckgefühl, Juckreiz, Schmerzen und Dyspareunie auftreten. Bei pudendaler Varikosis außerhalb der Schwangerschaft sollte ein pelvines Stauungssyndrom ausgeschlossen werden. Typisch sind Menstruationszyklus-abhängige Unterleibs- und Beinschmerzen. Zur Diagnostik der Refluxquelle eignet sich eine MR-Angiografie. Die Therapie erfolgt in der Regel ambulant und minimalinvasiv. Die isolierte pudendale Varikosis (keine Schwangerschaft, Ausschluss pelvines Stauungssyndrom erfolgt) kann mittels Sklerotherapie (Goldstandard) durch eine sequenzielle Therapie schonend und nebenwirkungsarm therapiert werden.