bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Treatment of Adult Intensive Care Patients: A Systematic Review and Meta-Analysis
Authors: Modra Lucy J. , Higgins Alisa M. , Abeygunawardana Vihangi S. , Vithanage Ruvini N. , Bailey Michael J. , Bellomo Rinaldo 
Published: February 2022

OBJECTIVES:
To evaluate and synthesize the available literature on sex differences in the treatment of adult ICU patients.

DATA SOURCES:
MEDLINE and EMBASE.

STUDY SELECTION:
Two reviewers independently screened publications to identify observational studies of adult ICU patients that explicitly examined the association between sex and ICU treatment—specifically, mechanical ventilation, renal replacement therapy, and length of stay.

DATA EXTRACTION:
We extracted data independently and in duplicate: mean age, illness severity, use of mechanical ventilation and renal replacement therapy, and length of stay in ICU and hospital. We assessed risk of bias using the Newcastle-Ottawa Scale. We used a DerSimonian-Laird random-effects model to calculate pooled odds ratios (ORs) and mean differences between women and men.

DATA SYNTHESIS:
We screened 4,098 publications, identifying 21 eligible studies with 545,538 participants (42.7% women). The study populations ranged from 246 to 261,255 participants (median 4,420). Most studies (76.2%) were at high risk of bias in at least one domain, most commonly representativeness or comparability. Women were less likely than men to receive invasive mechanical ventilation (OR, 0.83; 95% CI, 0.77–0.89; I
2 = 90.4%) or renal replacement therapy (OR, 0.79; 95% CI, 0.70–0.90; I
2 = 76.2%). ICU length of stay was shorter in women than men (mean difference, –0.24 d; 95% CI, –0.37 to –0.12; I
2 = 89.9%). These findings persisted in meta-analysis of data adjusted for illness severity and other confounders and also in sensitivity analysis excluding studies at high risk of bias. There was no significant sex difference in duration of mechanical ventilation or hospital length of stay.

CONCLUSIONS:
Women were less likely than men to receive mechanical ventilation or renal replacement therapy and had shorter ICU length of stay than men. There is substantial heterogeneity and risk of bias in the literature; however, these findings persisted in sensitivity analyses.
Lung-Dependent Areas Collapse, Monitored by Electrical Impedance Tomography, May Predict the Oxygenation Response to Prone Ventilation in COVID-19 Acute Respiratory Distress Syndrome
Authors: Cardinale Michael , Boussen Salah , Cungi Pierre-Julien , Esnault Pierre , Mathais Quentin , Bordes Julien , Meaudre Eric , Goutorbe Philippe 
Published: February 2022

OBJECTIVES:
ICUs have had to deal with a large number of patients with acute respiratory distress syndrome COVID-19, a significant number of whom received prone ventilation, which is a substantial consumer of care time. The selection of patients that we have to ventilate in prone position seems interesting. We evaluate the correlation between the percentage of collapsed dependent lung areas in the supine position, monitoring by electrical impedance tomography and the oxygenation response (change in Pao
2/Fio
2 ratio) to prone position.

DESIGN:
An observational prospective study.

SETTING:
From October 21, 2020, to 30 March 30, 2021. At the Sainte Anne military teaching Hospital and the Timone University Hospital.

PATIENTS:
Fifty consecutive patients admitted in our ICUs, with COVID-19 acute respiratory distress syndrome and required mechanical, were included. Twenty-four (48%) received prone ventilation. Fifty-eight prone sessions were investigated.

INTERVENTIONS:
An electrical impedance tomography recording was made in supine position, daily and repeated just before and just after the prone session. The daily dependent area collapse was calculated in relation to the previous electrical impedance tomography recording. Prone ventilation response was defined as a Pao
2/Fio
2 ratio improvement greater than 20%.

MEASUREMENT AND MAIN RESULTS:
The main outcome was the correlation between dependent area collapse and the oxygenation response to prone ventilation. Dependent area collapse was correlated with oxygenation response to prone ventilation (R
2 = 0.49) and had a satisfactory prediction accuracy of prone response with an area under the curve of 0.94 (95% CI, 0.87–1.00; p < 0.001). Best Youden index was obtained for a dependent area collapse greater than 13.5 %. Sensitivity of 92% (95% CI, 78–97), a specificity of 91% (95% CI, 72–97), a positive predictive value of 94% (95% CI, 88–100), a negative predictive value of 87% (95% CI, 78–96), and a diagnostic accuracy of 91% (95% CI, 84–98).

CONCLUSIONS:
Dependent lung areas collapse (> 13.5%), monitored by electrical impedance tomography, has an excellent positive predictive value (94%) of improved oxygenation during prone ventilation.
Development and Validation of an LC-MS/MS Method to Quantify Gilteritinib and Its Clinical Application in Patients With FLT3 Mutation–Positive Acute Myelogenous Leukemia
Authors: Zhang Mengyu , Tajima Soichiro , Suetsugu Kimitaka , Hirota Takeshi , Tsuchiya Yuichi , Yamauchi Takuji , Yoshimoto Goichi , Miyamoto Toshihiro , Egashira Nobuaki , Akashi Koichi , Ieiri Ichiro 
Published: February 2022

Background:
Gilteritinib, a novel oral tyrosine kinase inhibitor, is used to treat acute myeloid leukemia (AML) with FMS-like tyrosine kinase-3 (FLT3) mutations. Therapeutic drug monitoring (TDM) of gilteritinib is important for improving clinical outcomes and ensuring safety. Therefore, this study aimed to develop a simplified method for quantifying gilteritinib in human plasma using liquid chromatography–tandem mass spectrometry.

Methods:
Liquid chromatography was performed by using an Acquity BEH C18 column (50 mm × 2.1 mm, 1.7 μm) and a gradient elution with 0.1% formic acid in water (A) and acetonitrile (B). Detection was performed by using a Shimadzu tandem mass spectrometer through multiple reaction monitoring in the positive-ion mode.

Results:
The developed method enabled quantification of gilteritinib in 4 minutes and was validated by evaluating selectivity, calibration curve (10–1000 ng/mL, r2 > 0.99), a lower limit of quantification (LLOQ), accuracy (overall bias −4.2% to 1.9%), precision (intraday CV ≤ 7.9%; interday CV ≤ 13.6%), carryover, recovery, matrix effect, dilution integrity, and stability according to the US Food and Drug Administration (FDA) guidelines. This method was successfully applied to the TDM of gilteritinib trough concentrations in 3 patients with AML.

Conclusions:
The developed method fulfilled the FDA guideline criteria and can easily be implemented to facilitate TDM in patients receiving gilteritinib in a clinical setting.
A Delphi Study to Establish Research Priorities for Neuroscience Nursing
Authors: Bautista Cynthia , Hinkle Janice L. , Alexander Sheila , Hundt Beth , Rhudy Lori 
Published: February 2022

ABSTRACT

BACKGROUND: Establishing research priorities is essential not only to support evidence-based nursing practice but also to direct research agendas for nursing organizations such as the American Association of Neuroscience Nursing. METHODS: A 6-member Research Agenda Task Force selected potential research priorities based on a literature search of neuroscience nursing research. Using a 2-round, modified Delphi methodology, electronic surveys were distributed to 53 neuroscience nursing experts to gain consensus on the research priorities for neuroscience nursing. Survey data included demographics, agreement with selected gaps in neuroscience nursing research, and impact of selected neuroscience nursing research topics on the field. RESULTS: Twenty-six of 53 experts (49% response rate) participated in round 1, and 30 of 53 experts (57% response rate) participated in round 2. In round 1, the Research Agenda Task Force members revised the list of gaps in neuroscience nursing research to include only the top 39 ranked topics with greater than or equal to 73% agreement, created a new category “Professional Practice Issues,” and added 1 additional topic. In round 2, 14 topics were ranked greater than or equal to 70% impactful and identified as the top neuroscience nursing research priorities. CONCLUSION: The results of this study served as an effort for creating research priorities and enhancing research collaboration that focuses on neuroscience nursing. Focusing on gaps in the literature and setting research priorities can ultimately improve patient outcomes. Neuroscience nursing research priorities can be used to inform, guide, and aid nurse scientists, educators, and providers, and to inform agencies that provide research and program funding.
Research Priority Setting: The Current Landscape of Neuroscience Nursing Research
Authors: Hinkle Janice L. , Alexander Sheila , Avanecean Donna , Batten Janene , Bautista Cynthia , Hundt Beth , Rhudy Lori 
Published: February 2022

ABSTRACT

BACKGROUND: The American Association of Neuroscience Nurses established a 6-member Research Agenda Task Force in 2019 to identify neuroscience nursing research priorities to lead the field for the next 3 to 5 years. An early step in the process was a literature search to gain an understanding of the current landscape of neuroscience nursing research. METHODS: A search strategy was developed to locate relevant neuroscience nursing research. An experienced medical librarian performed a comprehensive systematic search of multiple databases. Task force members then further refined the search. A separate search was conducted to locate published research by 21 known neuroscience nurse researchers. RESULTS: An initial search located 466 qualitative articles and 1243 quantitative articles, with a further 655 articles published by known neuroscience nurse researchers. All 2364 citations were reviewed by task force members of the working in pairs to screen titles and abstracts for relevance. Nine categories of neuroscience nursing research were identified: quality of life, nursing practice, biomarkers, health promotion, professional development, technology, nursing care outcomes, assessment, and caregivers. Most of the research used descriptive methods, including both quantitative and qualitative methods of inquiry, providing a foundation for more rigorous investigation and interventional research. Research following stroke and the critical care setting were most prevalent. DISCUSSION: New and emerging trends in neuroscience nursing research include the use of technology, biomarkers, lay caregivers, strategies, and tools, including measure development for neurological assessment, and the evaluation of nursing practice including the practice environment and advanced practice nurse providers. Gaps were also evident. CONCLUSION: There is a significant need to expand neuroscience nursing in areas of emerging trends and to use rigorous methods to evaluate nursing practice effects on patient outcomes. The results of this search were used to revise the neuroscience nursing priorities last determined in 2011.
Risk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received
Authors: Cao Yi , Allore Heather , Gutman Roee , Vander Wyk Brent , Jørgensen Terese S.H. 
Published: February 2022

Background:
The correlations between skilled nursing facility (SNF) admissions, number of hospitalizations, and informal caregiving hours received after adjusting for physical and cognitive function and sociodemographic covariates are not well understood.

Objective:
The objective of this study was to better understand risk factors for SNF admissions and the interrelation with hospitalizations and amount of informal caregiving received, this study applied a novel joint modeling analysis to simultaneously explore the correlation and shared information between the 3 outcomes.

Research Design:
This was an observational follow-up study.

Subjects:
Data from 4836 older Americans included in the 2011–2015 rounds of the National Health and Aging Trends Study were linked with Centers for Medicare & Medicaid Services.

Measures:
We jointly modeled SNF admission, hospital admissions, and informal caregiving hours received while accounting for possible risk factors. We addressed missing values by multiple imputation with chained equations.

Results:
SNF admission evidenced a strong positive correlation with hospital admission, and SNF admission evidenced a weak positive correlation with the informal caregiving hours received after adjustment for important risk factors. Non-Hispanic White race/ethnicity, living alone, not being Medicaid eligible, Alzheimer disease and related dementias diagnosis, activities of daily living disabilities, and frailty were associated with increased risk of SNF admissions and any/number of hospital admission. Lower educational level was also associated with the latter. Medicaid eligibility was the only factor not associated with any nor numbers of informal caregiving hours received.

Conclusions:
Sociodemographic and health factors were important for predicting SNF admissions. After adjustment for important risk factors, SNF evidenced a strong positive correlation with the number of hospitalizations and a weak positive correlation with the hours of informal caregiving received.
The Diverse Phenotype of Intestinal Dysmotility Secondary to ACTG2‐related Disorders
Authors: Sandy Natascha S. , Huysentruyt Koen , Mulder Daniel J. , Warner Neil , Chong Karen , Morel Chantal , AlQahtani Saleh , Wales Paul W. , Martin Martin G. , Muise Aleixo M. , Avitzur Yaron 
Published: February 2022

ABSTRACTBackground and Aims:The initial description of a heterozygous dominant ACTG2 variant in familial visceral myopathy was followed by the identification of additional variants in other forms of intestinal dysmotility disorders. we aimed to describe the diverse phenotype of this newly reported and rare disease.Methods:Report of 4 new patients, and a systematic review of ACTG2‐related disorders. we analyzed the population frequency and used in silico gene damaging predictions. Genotype‐phenotype correlations were explored.Results:One hundred three patients (52% girls), from 14 publications, were included. Twenty‐eight unique variants were analyzed, all exceedingly rare, and 27 predicted to be highly damaging. The median Combined Annotation Dependent Depletion (CADD) score was 29.2 (Interquartile range 26.3–29.4). Most patients underwent abdominal surgery (66%), about half required intermittent bladder catheterization (48.5%), and more than half were parenteral nutrition (PN)‐dependent (53%). One‐quarter of the patients died (25.7%), and 6 required transplant (5.8%). Girls had a higher rate of microcolon (P = 0.009), PN dependency (P = 0.003), and death/transplant (P = 0.029) compared with boys, and early disease onset (<2 years of age) was associated with megacystis‐microcolon‐intestinal hypoperistalsis syndrome (MMIHS) features. There was no statistical association between disease characteristics and CADD scores.Conclusions:Damaging ACTG2 variants are rare, often associated with MMIHS phenotype, and overall have a wide phenotypic variation. Symptoms usually present in the perinatal period but can also appear at a later age. The course of the disease is marked by frequent need for surgical interventions, PN support, and mortality. Poor outcomes are more common among girls with ACTG2 variants.
Nutritional and Safety Concerns of Infant Feeding Trends
Authors: DiMaggio Dina M. , Du Nan , Porto Anthony F. 
Published: February 2022

ABSTRACTObjective:The American Academy of Pediatrics (AAP) and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition recommend either exclusively breastfeeding for at least 6 months or an u.S. Food and Drug Administration‐reviewed infant formula or donor breast milk from an established milk bank as alternatives. The purpose of this study was to establish the prevalence of contemporary infant feeding practices such as informal human milk sharing, imported European infant formula, toddler formula and homemade formula and gain insight into the parental reasoning for their choices.Study design:An anonymous, cross‐sectional, voluntary electronic survey was sent to active prescribers to a Yumi (a baby food subscription company) list server in April and May 2021. Basic demographic, utilization of infant feeding practices and general feeding practices were collected.Results:Of 2315 respondents, at least 18% of the families were following at least one contemporary feeding practice. Thirty six percent of parents using donor breast milk obtained it from unregulated sources, 14% of the respondents were using European infant formula, 5% were using toddler formula for their infants, and 2% were making homemade infant formula.Conclusion:The AAP has clear guidelines on infant nutrition and breastfeeding and when not possible, FDA reviewed infant formula or donor breast milk from an established milk bank as alternatives. Yet, our study found that at least 18% of the families across the united States were following at least one contemporary feeding practice with possible nutritional and safety concerns. it is important for pediatric gastroenterologists and dieticians to ask their patients how they are feeding their infants and be aware of these feeding practices that may pose significant health risks.
Rapid Infliximab Biosimilar Infusion in Children With Inflammatory Bowel Disease
Authors: O'Connell Daniel M. , Nachreiner Joshua , Shu Xin , Terry Erica , Imburgia Taylor , Vanderloo Joshua , Lasarev Michael R. , Bogenschutz Monica 
Published: February 2022

ABSTRACTObjectives:Compare prevalence of infusion reaction (IR) between infliximab (IFX) and infliximab biosimilar (IFX‐abda) at standard and rapid rates and measure the impact on health care cost in children with inflammatory bowel disease (IBD).Methods:Records of subjects receiving IFX and IFX‐abda were reviewed over a 21‐month period. Demographics and IRs were recorded. Cost analysis utilized average wholesale pricing, infusion duration, nursing time, and infusion center throughput.Results:Fifty‐six subjects received 498 infusions. Sixteen subjects received both IFX and IFX‐abda. Thirteen IRs occurred for an overall prevalence of 2.6%. One outlier subject accounted for 8 of 13 (62%) of IRs. Data were analyzed with and without the outlier. Standard rate infusion of both IFX and IFX‐abda was associated with increased risk of IR compared with rapid rate but only reached significance for IFX when calculated with the outlier removed. Risk of IR was not statistically significant between IFX and IFX‐abda for both standard and rapid rates. IFX‐abda saved an average of $2,611 per infusion. Rapid infusion saved 70 minutes of infusion time, 20 minutes of estimated nursing time per infusion, and decreased infusion center appointment length by as much as 2 hours per infusion.Conclusions:Rapid IFX‐abda appears safe without increased IRs and decreases cost.
Five‐Year Inpatient Management of Teenagers With Anorexia Nervosa
Authors: Trovato Chiara Maria , Capriati Teresa , Bolasco Giulia , Campana Carmen , Papa Valentina , Mazzoli Bianca , Zanna Valeria , Marchili Maria Rosaria , Basso Maria Sole , Maggiore Giuseppe , Diamanti Antonella 
Published: February 2022

ABSTRACTObjectives:In patients with Anorexia Nervosa (AN) malnutrition can lead to life‐long nutritional treatments. The refeeding process can combine natural feeding (NF) with specific nutritional strategies, including oral nutritional supplements (ONS) and nasogastric feeding (NGF). Aims of the present study were to assess the efficacy of hospital protocol and identify the most effective inpatient nutritional strategies for weight restoration.Methods:All patients hospitalized from April 2015 to April 2020 were enrolled. According to hospital protocol, NF was proposed to all patients; ONS were combined with NF if caloric intake was <70% of the requirements and NGF was added if caloric intake did not reach 30% in the first week from admission.Results:Overall, 186 patients [M = 20; median age 14 (interquartile range 1316)] were included. Nutritional issues were the main indication to admission (56.6%). A significant effect of combination treatment, with a shorter duration of hospitalization when using ONS with NGF in addition to NF was found (ß: —20.28 [95% confidence interval —34.92:—5.65], P < 0.001). Only one patient showed a significant but limited increase of liver enzymes.Conclusions:We provide a safe and effective standardized protocol to treat the malnutrition of teenagers with AN in an inpatient setting. Malnutrition was the most important cause of admission, and more than half of the patients admitted were severely malnourished. The combination of NF, ONS, and NGF was the most effective strategy to achieve the weight restoration; however, this result should be validated on larger series of patients treated with NGF and NF.
Identifying Needs, Challenges, and Benefits Among Adults and Parents of Children With Hirschsprung Disease
Authors: Berrios Courtney , Bollinger Juli , Yan Jia , Biesecker Barbara , Chakravarti Aravinda 
Published: February 2022

ABSTRACTAdults with Hirschsprung disease (HD), unaffected parents of children with HD, and affected adults with an affected child completed a cross‐sectional survey with open‐ended questions about greatest needs at diagnosis and at current time, greatest challenges encountered, and any benefits of having HD or having a child with HD. In the 297 respondents, information and good medical care were common needs at diagnosis and at the time of survey, but the information needed evolved with time. Managing ongoing symptoms was a frequently cited need and challenge, along with managing medical care and the social and emotional impact of HD. Perceived benefits included empathy for others and new perspectives on life. The needs and challenges identified in this study can guide healthcare providers in discussions with families. Provision of information, recommendations, and referrals based on each individual family's needs can support families with HD throughout the lifecycle and facilitate adaptation.