bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal rainfall pattern using coupled neural network-wavelet technique of of southern Uttarakhand, India
Authors: Singh Shekhar , Vishwakarma Dinesh Kumar , Kumar Rohitashw , Kushwaha N. L. 
Published: July 2022

Abstract
Uttarakhand, the land of peaceful, sanctity and venerable beauty. Most of its geographical area comes under the hill and the remaining areas lives in the belt of Tarai plains. The patchiness in topography has led to a significant change in the rainfall pattern. It is playing a vital role in water resource management and the field of hydrology. With the help of a statistical and hybrid model of Wavelet-ANN (WANN), the seasonal rainfall variation for theperiod of 1901 to 2016 in the southern part of Uttarakhand namely, Almora, Kashipur, Landsdown and Mukteswar was studied.The study was done on a seasonalbasis ofmonthly rainfall data.The statistical results suggested that the mean maximum rainfall was found to be 746.82 mm, 1586.58 mm, 1060.53 mm and 964.43 mm for Almora, Lansdown, Kashipur and Mukteswar respectively. For each season, four WANN modelshave been developed (total of sixteen models) by varying the number of hidden neurons. The results suggested that only one WANN model was not sufficient to predict the rainfall of all stations. Every station has a specific networked model which could model the data more preciously. The findings illustrated that the hybrid model of WANNhavingNetwork (4-7-1) was found best model for the Landsdown stations among all the stations.
Imaging investigation of cervicocranial artery dissection by using high resolution magnetic resonance VWI and MRA : qualitative and quantitative analysis at different stages
Authors: Ma Weiqiong , Zhou kexin , Lan Bowen , Li Wuming , Jiang Guihua 
Published: July 2022

Abstract
Background To explore the value of magnetic resonance angiography(MRA) and high resolution magnetic resonance vessel wall imaging(HRMR-VWI) in cervicocranial artery dissection(CCAD) diagnosis and disease staging.On the basis of qualitative evaluation,this study also extract the dynamic changes in vessel wall in different vessel segments to identify imaging indicators for the quantitative evaluation of CCAD. Methods We retrospectively enrolled 33 patients with CCAD（37 branches）with conventional MRA and HRMR-VWI examinations.Two radiologists independently analyzed imaging features of vessel wall and lumen in the different stages,and the typical sign detection of artery dissection were compared between MRA and HRMR-VWI.Then the parameters of vessel wall was quantitatively evaluated by Vesselmass.Results HRMR-VWI revealed typical sign detection of artery dissection in all patients in the acute and subacute stage.Among them,the intimal flap/double lumen sign ditection were more common than the MRA,there was significant difference(P=0.01).MRA revealed typical sign detection of artery dissection in more than half the patients,and the detection was no significant difference at the chronic stage between MRA and HRMR-VWI(P=1.000/1.000/0.761).In the acute and subacute stage, the typical sign detection of artery dissection revealed by HR-MRI was higher than the observations in the chronic stage(P=0.028),while there was no significant difference by MRA(P=0.682/1.000). The relative signal intensity of IMH and wall enhancement, wall thickness index were gradually decreased from the acute stage to the chronic stage;Significant differences were found between the recovered group of chronic stage and the acute stage(P＜0.05),but it is no significant difference between the recovered group of chronic stage and the acute stage(p=1.000、0.061).Conclusions As the only noninvasive imaging technology, HRMR-VWI displays the structure of the vessel wall in vivo, showing not only excellent performance in the early diagnosis of CCAD, but also describing the dynamic changes in the qualitative and quantitative characteristics of vessel wall. It also helps to guide the disease course, staging, prognosis, and treatment of CCAD.Although the diagnostic efficacy of MRA was not as good as HRMR-VWI, it should be the first choice of method for routine examination in evaluating CCAD, especially at the chronic stage of CCAD.
Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma
Authors: Wang Yi , Tian Weizhong , Tian Shuangfeng , He Liang , Xia Jianguo , Zhang Ji 
Published: July 2022

Abstract
Background
Spectral CT imaging parameters have been reported to be useful in the differentiation of pathological grades in different malignancies. This study aims to investigate the value of spectral CT in the quantitative assessment of esophageal squamous cell carcinoma (ESCC) with different degrees of differentiation༎
Methods
There were 191 patients with proven ESCC who underwent enhanced spectral CT from June 2018 to March 2020 retrospectively enrolled. These patients were divided into three groups based on pathological results: well differentiated ESCC, moderately differentiated ESCC, and poorly differentiated ESCC. Virtual monoenergetic 40keV-equivalent image (VMI40keV), iodine concentration (IC), water concentration (WC), effective atomic number (Eff-Z), and the slope of the spectral curve(λHU) of the arterial phase (AP) and venous phase (VP) were measured or calculated. The quantitative parameters of the three groups were compared by using one-way ANOVA and pairwise comparisons were performed with LSD. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of these parameters in poorly differentiated groups and non-poorly differentiated groups.
Results
There were significant differences in VMI40keV, IC, Eff-Z, and λHU in AP and VP among the three groups (all p < 0.05) except for WC (p > 0.05). The VMI40keV, IC, Eff-Z, and λHU in the poorly differentiated group were significantly higher than those in the other groups both in AP and VP (all p < 0.05). In the ROC analysis, IC performed the best in the identification of the poorly differentiated group and non-poorly differentiated group in VP (AUC = 0.729, Sensitivity = 0.829, and Specificity = 0.569 under the threshold of 21.08 mg/ml).
Conclusions
Quantitative parameters of spectral CT could offer supplemental information for the preoperative differential diagnosis of ESCC with different degrees of differentiation.
Bilateral orofacial clefts confer increased risk of psychiatric morbidity relative to unilateral clefts
Authors: Tillman Karin , Hakelius Malin , Höijer Jonas , Ramklint Mia , Ekselius Lisa , Nowinski Daniel , Papadopoulos Fotios 
Published: July 2022

Abstract
Background
Nonsyndromic orofacial clefts (OFC) are associated with neurodevelopmental disorders. The aim of this study was to compare children with bilateral clefts with unilateral clefts regarding psychiatric disorders.
Methods
We utilized data on all children born in Sweden between 1973 and 2012 with unilateral cleft lip (UCL), bilateral cleft lip (BCL), unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP). We performed Cox regression analyses with direct comparisons between bilateral and unilateral clefts compared to matched community cohorts and adjusted for confounders.
Results
Children with BCL showed risk increases for any psychiatric disorder (aHR 2.13, 95% CI 1.04–4.36), including intellectual disability (aHR 5.31, 95% CI 1.29–21.78) compared to UCL. Children with BCLP demonstrated risk increases for any psychiatric disorder (aHR 1.55, 95% CI 1.20–2.01), including speech and language disorders (aHR 1.99, 95% CI 1.00-3.97), neurodevelopmental disorders (aHR 1.66, 95% CI 1.11–2.47) and other psychiatric disorders (aHR 1.54, 95% CI 1.11–2.15), such as personality disorders (aHR 5.76, 95% CI 2.13–15.55) compared to UCLP.
Conclusions
This large nationwide register study shows for the first time that individuals with bilateral clefts demonstrate elevated risks of psychiatric disorders compared to unilateral clefts.
Association between Body Mass Index Structure and Physical Activity, Sleep, Sedentary Behavior, Health, Stress, Emotional Intelligence, and Healthy Eating: A Study of 8,759 People in Lithuania
Authors: Skurvydas Albertas , Lisinskiene Ausra , Majauskienė Daiva , Valanciene Dovile , Dadeliene Ruta , Fatkulina Natalja , Mockeviciene Daiva , Sarkauskiene Asta 
Published: July 2022

Abstract
Objective: To determine how the body mass index (BMI) structure (underweight, normal weight, overweight, and obesity grades I and II) affects the physical activity structure (light physical activity, moderate physical activity, and vigorous physical activity), sleep, sedentary behaviour, eating habits, stress, depression, health, and emotional intelligence.Results: We determined that health and stress depended on the BMI structure only among women and Emotional Intelligence depended on the body mass index structure only among men. Emotional Intelligence was higher among overweight and obese men than normal weight and underweight men. We found that light physical activity in women and men, and especially vigorous physical activity METs structures, sedentary, significantly were associated with the BMI structure, whereas sleep METs didn’t depend on the BMI structure in women and men. As BMI increases, vigorous physical activity significantly decreases in men and women. We identified a significant direct correlation relationship between vigorous physical activity and eating breakfast. We found that of all energy expenditure determinants vigorous physical activity had the best correlation with the BMI structure among women and men. We identified that BMI was closely and directly associated with the frequencies of overeating and skipping breakfast among women and men.
Perceptions of Social Media Safety in Japan
Authors: Kudo Noriko , Manabe Masae , Liew Kongmeng , Wakamiya Shoko , Ayaya Satsuki , Kumagaya Shinichiro , Aramaki Eiji 
Published: July 2022

Abstract
Background and objective: We often treat the dangers of social networking as similar across sites. However, this study demonstrates that users' perceptions of social media safety differs between social media platforms.Methods: We conducted a questionnaire of Japanese social media users (N = 7198) using an adapted version of the Psychological Safety Scale, to investigate the relationship between perceived psychological safety and the operational statistics associated with each social media platform. We then conducted data collection examining subjective classification from a different set of users (N = 2304).Results: Of the social networking sites examined, “Yahoo! Chiebukuro" and "note" were rated with high perceived psychological safety.The higher the number of monthly active users in Japan, the higher the psychological safety score, and there was also a positive correlation between login frequency and psychological safety. In addition, high openness and high self-disclosure were associated with low psychological safety.Conclusions: The psychological safety of social media sites was related to the number of domestic users, the number of logins, openness, and self-disclosure. These results of this study can be used as a reference for the design of social media platforms.
Impact of the application of NRS2002 by nurses and dieticians in a tertiary care centre: reliability and clinical outcomes
Authors: Deschepper Mieke , Duprez Veerle , Lapauw Bruno , Eeckloo Kristof , Marchand Sophie 
Published: July 2022

Abstract
Objective: To evaluate the level of agreement between nurse and dietician nutritional risk assessments, using the Nutritional Risk Screening 2002 (NRS2002) based risk screening protocol, to explore the effect of falsely labeling patients `not at risk` for malnutrition, and the effect of delayed involvement of the dietician (STD) on the length of stay (LoS).Methods: Including all patients hospitalized in a tertiary care center between January 2017 and December 2019 screened for malnutrition by both a nurse and a dietician. The inter-rater reliability is evaluated using Cohen’s Kappa. The relation between STD and the patient classification (PCET) is assessed by a linear mixed effect model. The relation between the LoS and PCET is evaluated with the Kaplan-Meier method and multivariate Cox regression including STD with pathology group and severity of illness as random effect.Results: 9085 patients are assessed by nurse and dietician. 72% of all assessments agree (Kappa=0.44 [0.43-0.46]). The dietician is involved later for patients falsely labeled ‘not at risk’ (1.06 [0.92 – 1.20] days; p<0.001). Compared to patients where the dietician is involved within three days, the LoS is 7.37 days (Hazard Ratio (HR): 0.51 [0.43-0.61]) longer for patients falsely labeled ‘not at risk’, while only 3.51 days (HR: 0.72 [0.64-0.80]) longer for patients correctly labeled ‘at risk’ . Conclusions: Agreement of screening for malnutrition between nurses and dieticians is weak. Avoiding falsely labeling patients `not at risk` should be a main concern upon patient admission as later involvement of dieticians is correlated with a longer LoS.
Mitochondrial DNA is a frequent target of HBV integration
Authors: Giosa Domenico , Lombardo Daniele , Musolino Cristina , Chines Valeria , Raffa Giuseppina , Tocco Francesca Casuscelli di , D’Aliberti Deborah , Caminiti Giuseppe , Saitta Carlo , Alibrandi Angela , Cigliano Riccardo Aiese , Romeo Orazio , Navarra Giuseppe , Raimondo Giovanni , Pollicino Teresa 
Published: July 2022

Abstract
Hepatitis B virus (HBV) may integrate into the genome of an infected cell and contribute to hepatocarcinogenesis. In this study, we applied a new high-throughput HBV integration sequencing approach that allows sensitive identification of HBV integration sites and enumeration of integration clones. We identified 3,339 HBV integration sites in paired tumour and non-tumour tissue samples from 7 patients with hepatocellular carcinoma (HCC). A total of 2,107 clonally expanded integrations were detected: 1,817 in tumour and 290 in non-tumour tissues. Moreover, we detected significant enrichment of clonal integrations in mitochondrial DNA (mtDNA), and HBV integration in mtDNA preferentially involved OXPHOS genes in tumours and the regulatory D-loop region in non-tumour tissues. We also found that HBV RNA sequences may be imported into the mitochondria of hepatoma cells, polynucleotide phosphorylase (PNPASE) is involved in this import, and HBV RNA might be involved in the process of HBV integration into mtDNA. Our data suggest a novel mechanism by which HBV insertion might contribute to HCC development.
Screening of single nucleotide polymorphisms within HLA region related to hematopoietic stem cell transplantation using MassARRAY technology
Authors: Tsai Shu-Hui , Chang Pi-Yueh , Wen Ying-Hao , Lin Wei-Tzu , Hsu Fang-Ping , Chen Ding-Ping 
Published: July 2022

Abstract
A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HSCT). Thus, other SNPs located nearby the classical HLA genes must be considered in HSCT. We evaluated the clinical feasibility of MassARRAY by comparing to Sanger sequencing. The PCR amplicons with each one of the 17 loci that were related to the outcomes of HSCT published by our previous study were transferred onto a SpectroCHIP Array for genotyping by mass spectrometry. The sensitivity of MassARRAY was 100% (1,419/1,419) and the specificity was 98.9% (470/475), where the positive predictive value (PPV) was 99.6% (1,419/1,424) and the negative predictive value (NPV) was 98.9%. MassARRAY is high-throughput, which can accurately analyze multiple SNPs at the same time. Based on these properties, it could accelerate the time of matching the genotype between the graft and the recipient before transplantation.
Modulation of the microbiota across different intestinal segments by Rifaximin in PI-IBS mice
Authors: Zhang Shengyan , Hong Gaichao , Li Gangping , Qian Wei , Jin Yu , Hou Xiaohua 
Published: July 2022

Abstract
Background
Rifaximin has been increasingly applied in irritable bowel syndrome (IBS) treatment. Whether there were differences in the effects of rifaximin on microbiota from different intestinal segments, especially the small intestine where rifaximin predominantly acted, has not been confirmed.
Methods
In this study, we used Trichinella spiralis infection to induce post infectious irritable bowel syndrome (PI-IBS) and measured visceral sensitivity of mice by means of abdominal withdrawal reflex (AWR) tests to colorectal distention (CRD). We compared the effects of rifaximin on the composition of ileal, colonic mucosal and fecal microbiota in PI-IBS mice.
Results
Rifaximin significantly reduced AWR scores and increased pain threshold in PI-IBS mice, and this effect was associated with the change in the relative abundance of ileal mucosal microbiota. Rifaximin could obviously decrease ileum mucosal microbiota alpha diversity assessed by Shannon microbial diversity index. Meanwhile, the analysis of beta diversity and relative abundance of microbiota at phylum, family and genus levels showed that rifaximin could improve the microbiota structure of ileal mucosa. However, for colonic mucosal and fecal microbiota, this effect of rifaximin was not obvious. Rifaximin could reshape the correlation of genera between different intestinal segments.
Conclusion
Rifaximin improved visceral hypersensitivity in PI-IBS mice. Rifaximin mainly affected ileal mucosal microbiota, and its improvement effect on IBS might be closely related to the improvement of ileal microbiota structure.
Undernutrition and associated Factors among Pregnant Women in East Borena Zone, Liban District, Oromia regional state, Ethiopia: A community-based cross-sectional study.
Authors: Dassie Godana Arero 
Published: July 2022

Abstract
Background
Undernutrition is “cellular imbalance b/n supply of nutrients, energy and body’s demand to ensure growth, maintenance, and specific function. However, there was no study conducted earlier on this topic in East Borena Zone.
Objective
To assess the prevalence of undernutrition and associated factors among pregnant women in East Borena Zone, Liban district.
Method
A community-based cross-sectional study was conducted on 500 study participants from November 20 to December 2021. The systematic sampling technique and simple random sampling methods were used to select study participants. Data were double entered into Epi-info software version 7 and SPSS version 21 software for analysis. Descriptive statistics were used to describe the characteristics of study participants. Bivariate and multivariable logistic regressions were carried out to identify the association between independent and dependent variables measuring the adjusted odds ratio and 95% confidence interval. P-values less than 0.05 were considered statistically significant.
RESULTS
Prevalence of undernutrition among pregnant women was about (44.9%) family monthly income [AOR = 8.72 (4.80, 15.83)], women decision making autonomy [AOR = 0.40 (0.19, 0.82)], skipping meal [AOR = 2.62 (1.41, 4.89)], substance use [AOR = 2.01 (1.07, 3.77)], household food insecurity [AOR = 2.01 (1.06, 3.80)], lack of prenatal dietary advices [AOR = 2.73 (1.53, 4.89)], absence of household latrine [AOR = 9.23 (3.48, 24.46)], not participating health development army’s meeting at village level [AOR = 3.01 (1.57, 5.72)] and hand washing habit [AOR = 6.55 (3.02, 14.20)] had shown statistically significant association with undernutrition.
Conclusion
The prevalence of undernutrition among pregnant women was high income, women's decision making autonomy, skipping meals, substances use, household food insecurity, lack of prenatal dietary advice, poor hand washing habit, lack of latrine, and not a participation in health development army’s meeting were found to be predictors of the undernutrition.
Mental Health among Children with Long COVID during the COVID- 19 Pandemic
Authors: Shachar-Lavie Iris , Shorer Maayan , Segal Hila , Fennig Silvana , Ashkenazi-Hoffnung Liat 
Published: July 2022

Abstract
Purpose
A growing number of studies report that persons of all ages, infected with SARS-CoV-2, may experience long-term persistent symptoms, known as Long-COVID (LC) or post COVID-19 condition. This is one of the first studies examining the consequences of LC on children’s mental health.
Method
In this case control study, we compared select mental health aspects of 103 children diagnosed with LC to a control group of 113 children uninfected with SARS-COV-2; all 4–18 years old. Both groups were assessed via parents’ questionnaires.
Results
In comparison to the control group, children with LC exhibited more memory difficulties. However, no group differences emerged in other functional aspects (connection with friends and engagement in physical activities), problems with concentration, or levels of emotional-behavioral problems (externalizing, internalizing, ADHD, and PTSD symptoms). We also found that children with LC had greater exposure to COVID 19 related stressors. Higher levels of parental worries regarding their children’s functioning and economic difficulties at home significantly predicted higher levels of children’s emotional-behavioral problems and were better predictors than the child’s age, social functioning, or LC diagnosis.
Conclusions
LC was associated with impairments in some aspects of children’s memory which may relate to academic functioning, but not with higher rates of emotional-behavioral problems, thus warranting interventional programs addressing school functioning and cognitive abilities in this population. Additionally, parents' economic stress and worries regarding their child’s emotional adjustment during the pandemic, are important factors affecting pandemic-related emotional-behavioral problems among children, regardless of COVID-19 infection, that should be addressed.
Design and preparation of MOF@PDA core-shell particles embedded with nano- Ag for PVDF dielectric composites
Authors: Chu Rui , Weng Ling , Guan Lizhu , Li Yuhan , Zhang Xiaorui , Wu Zijian 
Published: July 2022

Abstract
In recent years, dielectric composites as excellent energy storage materials have attracted extensive attention from scholars. Improving the energy storage density of dielectric composites can start from two aspects: increasing the dielectric constant and breakdown field strength of materials. In this paper, the metal-organic framework (MOF) ZIF-67 were selected, the polydopamine (PDA) core shell were coated on the surface of ZIF-67, and nano-Ag were embedded in the PDA, and MOF@PDA-Ag hybrid nanoparticles were prepared. Nanoparticles were introduced into the polyvinylidene fluoride (PVDF) matrix, and MOF@PDA-Ag/PVDF nanocomposites were prepared. The results show that ZIF-67 promote the generation of β-phase in the PVDF matrix, which improve the overall polarization capacity of the composites, thereby improving the mechanical properties and dielectric properties of the materials. Under the strengthening effect of nano-Ag, the dielectric constant of 7 wt% 10MOF@PDA-Ag/PVDF nanocomposite film reaches 15.6 (100 Hz), which is 54.5% higher than that of pure PVDF. Under the influence of the insulation stability of ZIF-67 and PDA and the Coulomb blocking effect of nano-Ag, the breakdown field strength of 5 wt% 10MOF@PDA-Ag/PVDF nanocomposite film is increased to 159kV/mm, which is 62.2% higher than that of pure PVDF.