bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home blood pressure monitoring schedule: optimal and minimum based on 2122 individual participants’ data
Authors: Kyriakoulis Konstantinos G. , Ntineri Angeliki , Niiranen Teemu J. , Lindroos Annika , Jula Antti , Schwartz Claire , Kollias Anastasios , Andreadis Emmanuel A. , McManus Richard J. , Stergiou George S. 
Published: June 2022

Objectives:
Home blood pressure (HBP) monitoring has become a primary method for hypertension diagnosis and management. This analysis aimed to investigate the optimal and minimum schedule for HBP monitoring.

Methods:
A retrospective analysis of cross-sectional data was performed, which involved HBP and 24-h ambulatory blood pressure (ABP) monitoring in adults performed within the context of clinical studies in Finland, Greece and UK. Participants with six to seven HBP monitoring days and at least 12 HBP readings were included. The stability of HBP was assessed by evaluating the average value of an increasing number of readings and its variability (SD). Its association with awake ABP was also assessed.

Results:
Data from 2122 participants were analysed (mean age 53.9 ± 11.3 years, males 53%, treated 34%). A progressive HBP decline was observed in succeeding days, reaching a plateau after day 3. Day 1 HBP was higher than in the next days by about 2.8/1.4 mmHg (systolic/diastolic, P < 0.001). In a 3-day HBP monitoring schedule, the exclusion of day 1 reduced average HBP and SD, with a clinically important HBP decline in 115 participants (5%) and different hypertension diagnosis in 120 participants (6%). For schedules including more than three HBP monitoring days, the exclusion of day 1 had negligible impact. The 3-day average HBP was strongly correlated with awake ABP, with a little improvement thereafter.

Conclusion:
These data support the recommendation for 7 days of HBP monitoring with a minimum of 3 days. Readings of the first day should be discarded, particularly when the minimum 3-day monitoring schedule is obtained (average readings of second and third day).
Blood pressure management through application-based telehealth platforms: a systematic review and meta-analysis
Authors: Kalagara Roshini , Chennareddy Susmita , Scaggiante Jacopo , Matsoukas Stavros , Bhimani Abhiraj , Smith Colton , Putrino David , Dangayach Neha S. , Mocco J. , Schnipper Jeffrey L. , Auerbach Andrew D. , Kellner Christopher P. 
Published: June 2022

Background and objectives:
Hypertension management has several challenges, including poor compliance with medications and patients being lost to follow-up. Recently, remote patient monitoring and telehealth technologies have emerged as promising methods of blood pressure management. We aimed to investigate the role of application-based telehealth programs in optimizing blood pressure management.

Methods:
Searches were performed in December 2020 using three databases: Cochrane Central Register of Controlled Trials, Embase and Ovid MEDLINE. All randomized controlled trials that included remote blood pressure management programmes were eligible for inclusion. Studies were included if blood pressure data were available for both the intervention and control groups. Following PRISMA guidelines, data were independently collected by two reviewers. Data were pooled using a random-effects model. The primary study outcomes were mean SBP and DBP changes for the intervention and control groups.

Results:
Eight hundred and seventy-nine distinct articles were identified and 18 satisfied inclusion and exclusion criteria. Overall, a mean weighted decrease of 7.07 points (SBP) and 5.07 points (DBP) was found for the intervention group, compared with 3.11 point (SBP) and 3.13 point (DBP) decreases in the control group. Forest plots were constructed and effect sizes were also calculated. Mean change effect sizes of 1.1 (SBP) and 0.98 (DBP) were found, representing 86 and 85% of the intervention group having greater SBP or DBP changes, respectively, when compared with the control group.

Discussion:
Remote patient monitoring technologies may represent a promising avenue for hypertension management. Future research is needed to evaluate the benefits in different disease-based patient subgroups.
Femtosecond Laser-assisted Cataract Surgery in Patients With Prior Glaucoma Surgery
Authors: Salimi Ali , Qi Susan R. , Harasymowycz Paul 
Published: June 2022

Précis:
Femtosecond laser-assisted cataract surgery (FLACS) is a safe procedure in glaucomatous eyes with prior glaucoma surgery, evidenced by stable intraocular pressure (IOP) and medication use, acceptable success rate, disease stability, and low complication rates at 1-year postoperative.

Purpose:
The purpose of this study was to assess the 1-year efficacy and safety of FLACS in glaucomatous eyes with prior glaucoma surgery.

Materials and Methods:
Retrospective case series of all consecutive glaucomatous eyes with previous glaucoma surgery that underwent FLACS using the Catalys Precision Laser System with or without concomitant glaucoma surgery at a single ophthalmology center, between 2014 and 2020. Efficacy included change in IOP, glaucoma medication use, best-corrected visual acuity, and surgical success at 12 months postoperatively (POM12). Safety included structural and functional measures of disease stability and postoperative adverse events.

Results:
A total of 57 eyes with an average age of 62.6±8.1 years were included. At POM12, IOP decreased from 14.5±6.6 mmHg to 13.5±3.7 mm Hg (P=0.22) and glaucoma medication use decreased from 2.1±1.5 to 1.8±1.4 with a marginal significance (P=0.089). Best-corrected visual acuity improved significantly in both groups (P<0.001) and surgical success ranged between 74% and 90% according to the study’s success criteria. Safety was favorable with disease stability evidenced by lack of deterioration in cup-to-disc ratio, visual field mean deviation, retinal nerve fiber layer thickness, and ganglion cell-inner plexiform layer thickness. One eye with prior history of trabeculectomy experienced transient bleb leak. Other adverse events were minor without sight-threatening sequelae.

Conclusions:
The results of this study suggest that FLACS with or without concomitant glaucoma surgery could be a safe procedure in glaucomatous eyes—a population for which FLACS has been relatively contraindicated. Nonetheless, in those with preexisting filtering bleb, extra attention should be paid to the bleb area.
Carbohydrate intake – current knowledge on weight management
Authors: Bayer Sandra , Holzapfel Christina 
Published: June 2022

Purpose of review
Carbohydrates are the main contributor to daily energy intake and, thus, might play an essential role in the development and treatment of obesity. This nonsystematic literature overview summarized current knowledge about the association between carbohydrate intake (quantity and quality) and weight management.

Recent findings
There is scientific evidence for the association between the quality of carbohydrates and body weight or metabolic parameters (e.g. fasting glucose). Thus, dietary intake of high-quality carbohydrates should be preferred over food with a low carbohydrate quality. In contrast, heterogeneous data are available for the association between the amount of carbohydrate intake and anthropometric parameters (e.g. body weight, body fat). Regulation of dietary intake and body weight is complex. For instance, gene-diet interactions might play a role in carbohydrate intake and metabolism.

Summary
There is evidence for the association between intake of high-quality carbohydrates and body weight. However, for the treatment of obesity, a negative energy balance is crucial. The success in weight loss was independent of the quantity and quality of carbohydrate intake. To sum up, recently published literature does not change the current opinion about carbohydrate intake and obesity.
Adrenal neuroendocrine carcinoma not responsive to EP regimen (cisplatin and etoposide)
Authors: Liu Kai , Zhuang Jiayi 
Published: June 2022

Introduction:
Neuroendocrine carcinoma is a malignant tumor that mostly occurs in the digestive tract and lungs but rarely occurs in the adrenal gland. It has a high degree of malignancy and poor prognosis. At present, there is lack of standard treatment protocols.

Patient concerns:
A 41-year-old woman presented with symptoms of repeated cough of one-month duration.

Diagnosis:
Laboratory tests, enhanced computed tomography imaging, and pathology confirmed the diagnosis of adrenal neuroendocrine carcinoma.

Interventions:
A chemotherapy regimen of cisplatin, etoposide (30 mg cisplatin d1–4+ 0.1 g etoposide d1–4) was formulated after multidisciplinary discussion.

Outcomes:
On the second day after the end of chemotherapy, the patient presented with bilateral lower extremity edema, decreased albumin, increased liver enzymes, new thrombus formation in the inferior vena cava and right external iliac vein, right pleural effusion and peritoneal effusion. Three episodes of convulsions of unknown cause occurred 22 days after the end of chemotherapy. L3 vertebral bone metastasis appeared 4 months after admission. Renal function deteriorated and multiple tumor metastases occurred throughout the body. The patient died 4 months and 10 days after admission.

Conclusion:
The prognosis of adrenal neuroendocrine carcinoma is extremely poor, and most patients have distant metastases. Chemotherapy regimens may be ineffective for some patients, and more clinical studies are needed to evaluate the effective treatment options.
Clinical effects of acupuncture on the treatment of delayed sleep wake phase disorder (DSWPD)
Authors: Yu XinTong , Li JinJin , Yang WenJia , Zhao Na , Zhang ChunYan , Chen XinYu , Liu Zhen , Xie Chen , Chen YunFei 
Published: June 2022

Background:
Delayed sleep–wake phase disorder (DSWPD) is a circadian rhythm sleep disorder. People with DSWPD fall asleep approximately 2 to 6hours later than those with normal sleep patterns, negatively affecting their ability to learn and work. According to some randomized controlled trials, acupuncture can effectively treat sleep disorders; however, no study has focused specifically on DSWPD. We verified the efficacy of acupuncture in patients with DSWPD by designing an randomized controlled trials with a sufficient sample size, and formed the basis for an improved acupuncture treatment protocol.

Method/Design:
This protocol describes a randomized, single-site, double-blind, sham-controlled trial in which 84 eligible participants will be enrolled and randomly distributed to either the acupuncture group (n = 42) or the sham acupuncture group (n = 42) in a 1:1 proportion. Participants will receive 20 treatment sessions over eight consecutive weeks. Sleep quality was evaluated by using the Pittsburgh Sleep Quality Index. The sleep parameters recorded will be used to measure the secondary results using actigraphy, the Morningness-Eveningness Questionnaire, Insomnia Severity Index Scale, Epworth Sleepiness Scale, Beck Depression Inventory, and Beck Anxiety Inventory. Primary outcomes and actigraphy will be evaluated at baseline, week 4, week 8, and at the first and third month after treatment.

Discussion:
We hypothesize that the outcomes of the proposed study will determine that acupuncture is efficient and secure for the treatment on DSWPD. Evidence for its clinical use could be provided by this positive result.

Trial registration:
Chinese Clinical Trial Registry, ChiCTR2000039450. Registered on October 28, 2020.
Malpractice lawsuits in orthopedic trauma surgery: a meta-analysis of the literature
Authors: Thabet Ahmed M. , Adams Austin , Jeon Soyoung , Pisquiy John , Gelhert Rick , DeCoster Thomas A. , Abdelgawad Amr 
Published: June 2022

Abstract

Introduction:
The objectives for this study were to identify whether diagnostic or procedural errors more commonly resulted in lawsuit, as well as to elucidate how specific variables affected mean indemnity.

Methods:
Systematic review of English-language articles in the PubMed and Google Scholar databases (through 2020) using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Meta-analysis was performed to estimate measures of proportions and differences in mean indemnity.

Results:
The estimated probability of lawsuits related to orthopedic trauma in overall studies was 23.3%. There were no significant rate differences between main causes of claims (diagnostic vs procedural errors) and areas of injury (upper vs lower). There was no significant difference of mean indemnity between the probabilities of trauma-related claims, diagnostic error, and procedural error.

Conclusion:
Non-trauma cases were more likely to result in lawsuit than trauma cases. Procedural errors accounted for most malpractice claims. The average indemnity increased according to the higher diagnostic errors, while the indemnity was lower with a relatively higher proportion of procedural errors. The most common cause of litigation varied between studies; however, among the most cited reasons were missed diagnosis/error in diagnosis, improper/substandard surgical performance, and, though not specifically studied in this analysis, errors of informed consent.

Level of Evidence:
Economic and Decision Analyses Level VI
Characteristics and Outcomes of COVID-19 Survivors Requiring Inpatient Rehabilitation: A Comparison of Two Waves
Authors: Gabunia Sergo , Harmon Erin Y. , Sonagere Matthew B. , Teale Amy E. 
Published: June 2022

Abstract

Objective
Many survivors of severe or critical COVID-19 have required rehabilitation during the pandemic. The primary objective was to compare characteristics and outcomes of survivors of severe or critical COVID-19 admitted to the inpatient rehabilitation facility (IRF) during the first two waves of the pandemic. Our secondary objective was to identify the factors contributing to functional dependence on admission, discharge and length of stay.

Design
Retrospective cohort study of 138 patients admitted to an IRF in two waves following hospitalization for severe or critical COVID-19 illness between April 1, 2020 and May 3, 2021.

Results
IRF patients in wave 2 had significantly greater functional independence (GG scores) on admission (52, IQR:44-58 versus 41, IQR: 28-52), lower incidence of dysphagia and anemia. Patients in both waves experienced similar functional improvement efficiencies with a median GG score change of 3.6 per day and similar discharge GG scores. Neurological sequela (OR: 0.12, P < 0.001) and anemia (OR: 1.35, P < 0.002) were identified as independent predictors of functional independence on admission.

Conclusion
Patients with functional deficits after COVID-19 should be considered for acute inpatient rehabilitation as both patient cohorts benefited from their IRF stays with similar length of stays (11-12 days) and discharge to home rates (88- 90%).
An Innovative Simulation Model for Microvascular Training
Authors: Zucal Isabel , Feder Anna-Lena , Kyaw Thura , Khin Sopyay , Heidekrueger Paul I. , Prantl Lukas , Haerteis Silke , Aung Thiha 
Published: June 2022

Summary:
Preclinical/clinical microsurgical training is essential for clinical practice. Therefore, various training models have been established, such as synthetic and cadaveric models. The most common limitation of these models is the lack of circulation, which limits the simulation of real intraoperative circumstances. Thus, the authors aimed to create a novel model that provides blood circulation with an extracorporeal perfusion device that they attached to rat cadavers for the reestablishment of a circulatory system. Patent blue and heparin were added to the perfusion fluid to visualize circulation and to dissolve thrombosis, and indocyanine green fluorescent imaging was applied to show the perfusion of the entire body. The femoral and brachial vessels were dissected, and an end-to-end anastomosis was performed on the femoral artery. The patency of the operated vessel was visualized with indocyanine green fluorescent imaging. Indocyanine green fluorescent imaging showed appropriate vessel patency and extremity perfusion through the anastomosis. The use of this novel rat model enables a solution for ethical problems encountered when using rats for surgical training courses. By practicing on these animal-sparing models with intact circulation, microsurgical skills can be improved. Future studies on further microsurgical techniques and vascular perfusion of organs or tumors may benefit from our model.
Tongue Flap for Management of Large Palatal Fistulas
Authors: Giugliano Carlos , Roldán Nicole , Claure Pilar , Suarez Vivian 
Published: June 2022

Abstract:
One of the worst complications after a primary palatoplasty is the lesion of the neurovascular bundle, results into a type of flap necrosis, having as a final consequence a residual palatine fistula.
In our institution the authors usually use tongue flap to repair large fistulas.
The authors retrospectively reviewed all patients with large palatal fistulas that were repaired with tongue flap at Fundacion Gantz between January 2002 and December 2020.
Fundacion Gantz has 1.067 patients with palatal surgeries, with an incidence of 5,8% for palatal fistulas and 3,2% (n = 2) were considered large.
Surgery was done on 24 patients with large residual palatal fistula, all of them with tongue flaps as outpatient surgery. Fifteen were girls and 9 were boys, between 13 and 40 years.
The average size of the fistula was 2,5 cm and 100% are localized in the anterior palate.
The incidence of complications with tongue flap was 12, 5%: 2 dehiscences and 1 persistent residual fistula. The authors had no complications in phonation due to the lingual donor area.
The authors consider that this outpatient surgery, is a reprodutible and safe technique, with a low rate of complications, which allows us to recommend it for the treatment of large palatal fistulas.
The Use of the Three-Dimensional Printed Polyether Ether Ketone Implant in Secondary Craniosynostosis Revision
Authors: Atamian Elisa K. , Hazkour Nissim , Palacios Jose , Pessino Kenneth , Raza Syed A. , Schneider Steven J. , Bastidas Nicholas 
Published: June 2022

Background:
Skull deformities may be seen in patients years after craniosynostosis correction. These deformities cause psychosocial distress in affected patients. In this series, the authors describe the use of patient specific polyether ether ketone (PEEK) implants for correction of skull deformities after cranial vault remodeling for craniosynostosis.

Methods:
A chart review was conducted for 3 revision procedures performed by 1 plastic surgeon in collaboration with 1 neurosurgeon, both affiliated with Northwell Health. Preoperative computed tomography scans were used to design three-dimensional (3D) printed PEEK implants manufactured by KLS Martin. Implants were used to correct frontal and orbital asymmetry and skull deformities in each patient. Outcomes were assessed at 1 week, 1 month, and 3 months post-operation.

Results:
Two males and 1 female, ages 13, 17, and 19, underwent revision cranioplasty or orbital rim reconstruction using a custom, single piece 3D printed PEEK implant. All 3 patients underwent cranial vault remodeling in infancy; 1 was treated for coronal craniosynostosis and 2 were treated for metopic craniosynostosis. Revision cranioplasty operative times were 90, 105, and 147 minutes, with estimated blood loss of 45 mL, 75 mL, and 150 mL, respectively. One patient went home on post op day 1 and 2 patients went home on post op day 2. All patients had an immediate improvement in structural integrity and cranial contour, and all patients were pleased with their aesthetic results.

Conclusions:
Custom 3D printed PEEK implants offer a single piece solution in revision cranioplasty surgery to correct skull deformities after cranial vault remodeling for craniosynostosis.
Continuous Interstitial Glucose Measurement for Flap Venous Occlusion Monitoring in a Diabetic Model
Authors: Zhang Chang , Wang Qianwen , Wu Lehao , Wang Jue , Zhao Sichun , Wang Jiaqi 
Published: June 2022

Abstract:
Glucose has been used in the monitoring of transplanted flaps. However, few studies have focused on the effect of diabetes on the decrease in flap glucose levels. The purpose of this study was to evaluate the application of continuous interstitial glucose monitoring to detect flap venous occlusion in a diabetic rat model. The flap interstitial glucose level was measured by transcutaneous sensors in the bilateral vertical rectus abdominis myocutaneous flaps of each rat. interstitial glucose values in the bilateral flaps were recorded every 5 minutes after the venous occlusion of 1 flap. Forty-one rats were divided into the control group (n = 13), diabetic group (n = 15, established by the intraperitoneal injection of streptozotocin), and insulin-treated diabetic group (n = 13, systemic glucose well controlled by insulin before surgery). Results indicated that flap interstitial glucose decreased to the lowest level in all flaps with venous occlusion. The time from venous occlusionto the lowest interstitial glucose level was significantlylongerinthe diabetic group than the control group (120.8 ± 5.7 minutes versus 56.5 ± 6.7 min-minutes, P < 0.001), but was similar in the insulin-treated diabetic and control groups (56.5 ± 6.7 minutes versus 56.0 ± 6.6 minutes, P = 0.876). The change in interstitial glucose in both the diabetic and insulin-treated diabetic groups began with a plateau period or a slow decline before decreasing for 49.0 ± 6.4 minutes and 24.4 ± 4.3 min-minutes, respectively. in a diabetic rat model, impaired glucose metabolism prolongs the required monitoring time and dulls the reaction of flap interstitial glucose to venous congestion. Insulin restores the prolonged monitoring time, but not the reaction of flap interstitial glucose. Therefore, care is needed during application of the technique in diabetic patients.
Cadaveric Bone Allografting for Severe Mandibular Hypoplasia With Alleviation of Upper Airway Obstruction in Goldenhar Syndrome
Authors: Villavisanis Dillan F. , Blum Jessica D. , Cho Daniel Y. , Taylor Jesse A. 
Published: June 2022

Abstract:
Severe congenital mandibular hypoplasia may cause significant upper airway obstruction, often necessitating immediate tracheostomy. Recent surgical advances have demonstrated early intervention with mandibular distraction osteogenesis over tracheostomy may yield desirable aesthetic and functional outcomes. Here we present a case of bilateral mandibular hypoplasia, severe on the right and mild on the left, secondary to Goldenhar syndrome yielding significant tongue-based upper airway obstruction that was surgically corrected with mandibular bone allograft reconstruction of the right condyle, ramus, and posterior half of the mandibular body. Postoperative polysomnography revealed significantly improved obstructive apnea and computed tomography demonstrated adequate placement of the bone allograft to overcorrect the affected hemi-mandible. To the authors’ knowledge, this is the first report of immediate mandibular allografting alleviating tongue-based upper airway obstruction secondary to mandibular hypoplasia in an infant. Mandibular bone allografting may be a favorable alternative to immediate tracheostomy with delayed surgical intervention, though long-term follow up is needed to assess graft durability and maintenance of airway patency.