bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical outcomes of using the nonirradiated and irradiated allograft for anterior cruciate ligament (ACL) reconstruction: A systematic review update and meta-analysis
Authors: Liu Yan , Liu Xuegang , Liu Yancai , Yang Shan 
Published: August 2022

Background:
This study was a systematic review comparing the clinical outcomes of using the nonirradiated and irradiated allograft for anterior cruciate ligament (ACL) reconstruction.

Methods:
A comprehensive literature search was conducted using multiple databases, including Medline, Embase, and Cochrane. All databases were searched from the earliest records through August 2019 using the following Boolean operators: irradiated AND nonirradiated AND ACL AND allograft. All prospective and retrospective controlled trials were retrieved that directly compared physical examination and knee function scores and patient-rated outcomes between the nonirradiated and irradiated allograft for ACL reconstruction.

Results:
Three prospective and 2 retrospective articles were identified by the search, and the findings suggested that the nonirradiated allografts were superior to the irradiated allografts based on improved knee joint functional scores and decreased failure rate, even though there was no significantly difference with respect to overall IKDC, range of motion, vertical jump test, and one-leg hop test.

Conclusions:
Irradiated allograft should be limited to be used in ACL surgery and further research into new alternative sterilization techniques are needed to avoiding the disease transmission without interference with the biomechanical properties of the grafts.
Two cases of aldosterone and cortisol producing adenoma with different histopathological features: A case report
Authors: Gao Hongjiao , Li Li , Tian Haoming 
Published: August 2022

Rationale:
Primary aldosteronism (PA), including aldosterone and cortisol producing adenoma (A/CPA), is the most common trigger of secondary hypertension. The prevalence of A/CPA may be higher than what we could recognize previously with similar studies, but only a few relevant immunohistochemical reports have confirmed this information. Collecting more clinical features and immunohistochemistry data may help us to understand A/CPA, which is very important for avoiding misdiagnosis and improving outcomes in patients with A/CPA.

Patient concerns:
Both individuals included in this study had hypertension for >10 years. Computed tomography scans revealed the presence of adrenal nodules 1 year ago in patient A and 10 months ago in patient B (based on the date of the final version of this report). The relevant clinical features support PA accompanied by subclinical Cushing syndrome.

Diagnosis:
Aldosterone and cortisol producing adenoma.

Interventions:
The adrenal adenoma on the affected side was removed and pathological examination and immunohistochemistry were performed. Both the patients received short-term hydrocortisone treatment.

Outcomes:
The blood pressure of both patients improved after surgery. Cytochrome P450 (CYP)11B1, CYP11B2, parathyroid hormone receptor 1 (PTH1R), calcium-sensing receptor (CaSR), and vitamin D3 receptor (VD3R) were all positively expressed, but the histopathological features of the expression region differed.

Lessons:
The occurrence of A/CPA may be related to calcium metabolism disorders. For A/CPA, the diversity in immunohistochemistry suggests many uncertainties regarding the pathogenesis of the disease. A/CPA should be considered in new clinical and pathological classifications of PA to gain more attention from the medical community.
Empathy ability of nursing students: A systematic review and meta-analysis
Authors: Jia-Ru Jiao , Yan-Xue Zheng , Wen-Nv Hao 
Published: August 2022

Background:
Empathy is an ability that nursing students need in clinical practice, there is no available data to assess nursing students’ empathy ability level . The main purpose of this study is to synthesize the evidence relating to the empathy ability in nursing students to systematically evaluate the empathy ability level among nursing students.

Methods:
Adhering to the preferred reporting items for Systematic Reviews and Meta-analyses guidelines, we searched PubMed, Cochrane, Web of Science, Scopus, ScienceDirect, Wiley Library, Embase, CNKI, Wanfang, and China biomedical literature service system ten databases to collect cross-sectional studies on nursing students’ empathy ability. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies.

Results:
A total of 19 cross-sectional studies were included. The sample comprised 5407 nursing students. Meta-analysis showed that females have a higher empathy ability than males, and the empathy ability of rural students is higher than that of provincial students.

Conclusions:
The findings suggest that the empathy ability among nursing students worldwide is higher, but there needs further improvement. This result makes nursing educators pay more attention to the cultivation of the nursing students’ empathy ability; improving the empathy level is beneficial in improving the standards of health care and patients’ quality of life.
Lung contusion after extracorporeal shock wave lithotripsy for pancreatic stones: A case report
Authors: Yi Jin-Hui , Wang Dan , Chen Hui , Li Zhao-Shen , Hu Liang-Hao 
Published: August 2022

Background:
Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for large pancreatic stones. While complications such as post-P-ESWL pancreatitis, bleeding, infection, steinstrasse, and perforation have been reported in the past 30 years, lung contusion has never been reported. The present case demonstrates lung contusion as a complication after P-ESWL.

Methods:
A 48-year-old man was admitted to our department due to painful chronic pancreatitis with pancreatic duct stones. Computed tomography revealed normal lungs. P-ESWL was performed. The shock wave head contacted with right upper quadrant and the path of shock wave was at a 45° angle to the ventral midline. After P-ESWL, multiple patchy high-density shadows in the lower lobe of right lung were found, which was normal before P-ESWL. The patient had no symptoms of lung injury.

Results and Conclusion:
Laboratory studies revealed elevated D-dimer from 0.33 to 0.74 ug/mL, which was consistent with abnormal clotting of lung contusion. Chest computed tomography showed slight pleural effusion. Considering the interval between 2 X-rays was only 3 hours, we inferred that lung contusion was related to P-ESWL. The patient displayed stable vital signs, therefore, no specific interventions were conducted. Three days after P-ESWL, endoscopic retrograde cholangiopancreatography was performed and the lung shadows were partially absorbed. Considering the location of shock wave head, it was possible to cause lung contusion in lower lobe of right lung. More than 10,000 P-ESWL therapeutic sessions had been performed in our center since 2010, and it is the first case about lung contusion as a complication. It is also the first report to describe lung contusion after P-ESWL. Although the patient was asymptomatic, it should raise awareness of clinicians.
Mismatch Repair Deficiency in Adult Granulosa Cell Tumors: an Immunohistochemistry-based Preliminary Study
Authors: Gupta Parikshaa , Kapatia Gargi , Gupta Nalini , Ballari Nagarjun , Rai Bhavana , Suri Vanita , Rajwanshi Arvind 
Published: August 2022

Objective:
Adult granulosa cell tumors (AGCTs) are rare ovarian malignant neoplasms; their etiopathogenetic mechanisms remain largely unelucidated. Lately, defects in mismatch repair (MMR) have been implicated in the pathogenesis of AGCTs. Demonstration of MMR deficiency in these tumors can help identify patients potentially eligible for immune checkpoint inhibition therapy. The present study was done to explore the role of MMR deficiency in the etiopathogenesis of AGCTs.

Methods:
This was a retrospective study conducted on histopathologically confirmed AGCT cases. MMR protein expression was evaluated by immunohistochemistry (IHC) on tissue microarrays using an antibody panel of MSH2, MSH6, MLH1, and PMS2.

Results:
Of a total of 40 ovarian AGCTs evaluated for MMR deficiency, none demonstrated loss of expression of any of the 4 MMR proteins.

Conclusions:
The results of our preliminary study show that there is no association between MMR deficiency with AGCT. Nevertheless, larger multicenter studies are needed to confirm or refute this observation.
Novel Microvascular Clamps to Aid Trainee Surgeon Education: Smarter than Acland Micro Clamps?
Authors: Saha Shivangi , Mohammad Arbab , Escandón Joseph M. , Chauhan Shashank 
Published: August 2022

Summary
Amongst the common microsurgical errors by trainees-Inadvertent backwall suturing and incomplete bites account for 21.7% and 19.6% of the total number of errors respectively. These errors are attributed to poor visibility of the suture and needle within the vessel lumen. We aimed to analyze and compare the errors during microvascular anastomosis with the use of an adventitia holding microvascular-clamp (AHM) and a regular Acland microvascular-clamp.We performed twenty-five vascular anastomoses, twelve using the AHM clamp and thirteen controls. Overall, sixteen were venous anastomosis performed for free flaps and nine were arterial anastomosis following arterial injury. The 3 jaw adventitia holding microvascular clamp was a versatile instrument during microsurgery, as it reduced the time required for anastomosis, the need for assistance, prevented backwall sutures, and the need to flip the clamp.
Recent advances in establishing a cure for GNE myopathy
Authors: Yoshioka Wakako , Nishino Ichizo , Noguchi Satoru 
Published: August 2022

Purpose of review
GNE myopathy is a rare autosomal recessive disease caused by biallelic variants in the GNE gene, which encodes an enzyme involved in sialic acid biosynthesis. No drugs are approved for the treatment of GNE myopathy. Following proof-of-concept of sialic acid supplementation efficacy in mouse models, multiple clinical trials have been conducted. Here, we review clinical trials of sialic acid supplementation therapies and provide new insights into the additional clinical features of GNE myopathy.

Recent findings
Clinical trials of sialic acid supplementation have been conducted in Europe, the USA, Japan, and South Korea. Some clinical trials of NeuAc-extended release tablets demonstrated amelioration of decline in upper extremity muscle strength; however, no significant improvement was observed in phase 3 trials in Europe and USA. A phase 2 trial of ManNAc showed slowed decline of both upper and lower extremity strength. GNE myopathy patient registries have been established in Europe and Japan, and have provided information on extramuscular manifestations such as thrombocytopenia, respiratory dysfunction, and sleep apnea syndrome. Sensitive and reliable biomarkers, and a disease-specific functional activity scale, have also been investigated.

Summary
We discuss recent advances in establishing a GNE myopathy cure, and discuss other prospective therapeutic options, including gene therapy.
Exercise Training Remodels Inguinal White Adipose Tissue Through Adaptations in Innervation, Vascularization and the Extracellular Matrix
Authors: Nigro Pasquale , Vamvini Maria , Yang Jiekun , Caputo Tiziana , Ho Li-Lun , Papadopoulos Danae , Carbone Nicholas P. , Conlin Royce , He Jie , Hirshman Michael F. , White Joseph D. , Robidoux Jacques , Hickner Robert C. , Nielsen Søren , Pedersen Bente K. , Kellis Manolis , Middelbeek Roeland J. W. , Goodyear Laurie J. 
Published: August 2022

ABSTRACTInguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. Extracellular matrix (ECM) composition, innervation, and vascularization are all important regulators of iWAT function, yet whether exercise training improves these structural components of iWAT is unknown. Using biochemical, imaging, and multi-omics analyses we find that 11-days of wheel running in male mice causes profound iWAT remodeling including decreased ECM deposition and increased vascularization and innervation. We identify adipose stem cells as the main contributors to training-induced ECM remodeling, determine that training causes a shift from hypertrophic to insulin-sensitive adipocyte subpopulations, show that the PRDM16 transcriptional complex is necessary for iWAT remodeling and beiging, and discover neuronal growth regulator 1 (NEGR1) as a link between PRDM16 and neuritogenesis. Exercise training leads to remarkable adaptations to iWAT structure and cell-type composition that can confer beneficial changes in tissue metabolism.Graphical Abstract
A systematic study of HIF1A cofactors in hypoxic cancer cells
Authors: Zhang Yuxiang , Wang Saidi , Hu Haiyan , Li Xiaoman 
Published: August 2022

AbstractHypoxia inducible factor 1 alpha (HIF1A) is a transcription factor (TF) that forms highly structural and functional protein-protein interactions with other TFs to promote gene expression in hypoxic cancer cells. Despite the importance of these TF-TF interactions, we still lack a comprehensive view of many of the TF cofactors involved and how they cooperate in hypoxic cancer cells. In this study, we systematically studied HIF1A cofactors in eight cancer cell lines and discovered 201 potential HIF1A cofactors. These cofactors were statistically and biologically significant, with 30 of the top 37 cofactors validated or supported in the literature. Moreover, these predicted cofactors include 21 of the 29 known HIF1A TF cofactors in public databases. These discovered cofactors can be essential to HIF1A’s regulatory functions and may lead to the discovery of new therapeutic targets in cancer treatment.
Self-produced hydrogen sulfide improves ethanol fermentation by Saccharomyces cerevisiae and other yeast species
Authors: Espinoza-Simón Emilio , Moreno-Alvarez Paola , Nieto-Zaragoza Elias , Ricardez-García Carolina , Ríos-Castro Emmanuel , Uribe-Carvajal Salvador , Torres-Quiroz Francisco 
Published: August 2022

AbstractHydrogen sulfide (H2S) is a gas produced endogenously in organisms from the three domains of life. In mammals, it is involved in diverse physiological processes, including the regulation of blood pressure, and its effects on memory. In contrast, in unicellular organisms the physiological role of H2S has not been studied in detail. In yeast, for example, in the winemaking industry H2S is an undesirable byproduct because of its rotten egg smell; however, its biological relevance during fermentation is not well understood. The effect of H2S in cells is linked to a posttranslational modification in cysteine residues known as S-persulfidation. We evaluated S-persulfidation in the Saccharomyces cerevisiae proteome. We screened S-persulfidated proteins from cells growing in fermentable carbon sources and we identified several glycolytic enzymes as S-persulfidation targets. Pyruvate kinase, catalyzing the last irreversible step of glycolysis, increased its activity in the presence of a H2S donor. Yeast cells treated with H2S increased ethanol production; moreover, mutant cells that endogenously accumulated H2S produced more ethanol and ATP during the exponential growth phase. This mechanism of the regulation of the metabolism seems to be evolutionarily conserved in other yeast species, because H2S induces ethanol production in the pre-Whole Genome Duplication species Kluyveromyces marxianus and Meyerozyma guilliermondii. Our results suggest a new role of H2S in the regulation of the metabolism during fermentation.
The logical structure of experiments lays the foundation for a theory of reproducibility
Authors: Buzbas Erkan O. , Devezer Berna , Baumgaertner Bert 
Published: August 2022

AbstractThe scientific reform movement has proposed openness as a potential remedy to the putative reproducibility or replication crisis. However, the conceptual relationship between openness, replication experiments, and results reproducibility has been obscure. We analyze the logical structure of experiments, define the mathematical notion of idealized experiment, and use this notion to advance a theory of reproducibility. Idealized experiments clearly delineate the concepts of replication and results reproducibility, and capture key differences with precision, allowing us to study the relationship among them. We show how results reproducibility varies as a function of: the elements of an idealized experiment, the true data generating mechanism, and the closeness of the replication experiment to an original experiment. We clarify how openness of experiments is related to designing informative replication experiments and to obtaining reproducible results. With formal backing and evidence, we argue that the current “crisis” reflects inadequate attention to a theoretical understanding of results reproducibility.
The state of diversity among leadership roles within Canada's largest arts and cultural institutions
Authors: Wall-Andrews Charlie , Wijesingha Rochelle , Cukier Wendy , Lightwala Owais 
Published: August 2022

PurposeThis paper aims to answer the following research questions: Does the Canadian Arts Summit's membership (i.e. Canada’s largest cultural institutions) reflect Canada's diversity? What is the state of diversity among leadership roles within Canada's largest cultural institutions when viewed through a geographical, gender and racial diversity, and intersectional lens?Design/methodology/approachEmploying a geographic, gender, racial diversity and intersectional lens, the authors investigated the largest and most influential arts and cultural organizations in Canada (n = 125) to examine their leadership diversity. The authors found that there is a disconnect between the diversity of Canada and the leadership representation among the largest arts organizations. The authors rationalize the management implications of a lack of diversity leading Canada's cultural sector.FindingsThe leadership of major arts organizations in Canada does not reflect the diversity of Canada's population. For example, among 125 Canadian Arts Summit organizations, only 5.7% of CEOs are racialized compared to 94.3% who are White. The findings show similar results for lack of diversity in the Artistic Director and Chair of the Board roles.Originality/valueThere is limited research using this methodology to investigate leadership diversity, especially in the arts and culture sector. This research can create a benchmark for the sector to improve the status quo. The value of this research aims to encourage policy actors and arts leaders to address diversity and inclusion within their organizations and the communities they aim to serve. This research provides the foundation for future studies exploring leadership diversity and representation in the Canadian arts sector.
Putting your money where your mouth is – the role of rewards in a value-based understanding of restaurant crowdfunding
Authors: Kedas Satishwar , Sarkar Soumodip 
Published: August 2022

Purpose
Restaurant entrepreneurs are increasingly leveraging crowdfunding as an alternative financing mechanism. In the context of restaurant crowdfunding, studies have identified factors related to campaign communication that affect crowdfunding success from the entrepreneurs’ perspective. Integrating a funder perspective, this study aims to investigate the role of the consumption value offered by rewards and builds a value-based understanding of restaurant crowdfunding.

Design/methodology/approach
This study uses a sample of 3,134 restaurant campaigns launched on the Kickstarter crowdfunding platform, and texts of 34,128 rewards were analyzed using a Python program. A hierarchical linear regression approach with a generalized logistic regression model was adopted to test hypothesized relationships.

Findings
Drawing upon consumption value theory (CVT), this study finds that in restaurant crowdfunding, utilitarian value holds a strong inverted-U relationship and participatory value holds a strong linear relationship with crowdfunding success. However, socioemotional value does not have a significant effect on outcomes. This study also finds evidence for positive effects of greater variety, higher number of rewards and lower average pledge level on restaurant crowdfunding success.

Practical implications
This study extends the literature on restaurant crowdfunding by integrating insights on the effects of value offered through rewards. Primarily, this study finds evidence for distinct effects of consumption values for restaurant crowdfunding audience. Practically, this study holds implications for reward menu design and value offering design for restaurant entrepreneurs seeking crowdfunding.

Originality/value
Restaurant crowdfunding has been studied to a limited extent, with extant literature focusing on characteristics of campaign descriptions. The role of rewards is uncovered using CVT and thus a value-based understanding of restaurant crowdfunding is presented.
Why are newly established Internet loss-making enterprises always willing to expand overseas rapidly: blocking competitors or seeking opportunity
Authors: Zheng Xiaobi , Qian Jiayue , Chen Danbo 
Published: August 2022

PurposeMany newly established Internet loss-making enterprises (NEILEs) are always willing to expand overseas within a very short time from their establishment. This phenomenon is becoming a hot research area. This paper aims to explore why these enterprises are always willing to expand overseas rapidly even if they are facing severe and persistent losses, and to study the different rapid internationalization modes and the international market entry ways for NEILEs.Design/methodology/approachThis paper constructs a theoretical framework with the dual situation of negative attainment discrepancy and advantageous slack resources to explain the rapid internationalization of NEILEs. Furthermore, cross-case comparative analysis method, based on interviews, questionnaires and secondary data collection, is adopted to reveal the rapid internationalization modes and the international market entry ways of such enterprises.FindingsWhether blocking competitors or seeking opportunities or both, NEILEs' goal of rapid internationalization depends on the severity and persistence of negative attainment discrepancy. When the severity and persistence of negative attainment discrepancy are very significant, moderate and mild, NEILEs choose sniper-type, opportunity-type and dual-type internationalization target mode in turn; it is very important for NEILEs to match advantageous slack resources and international market entry ways to achieve specific internationalization goals.Research limitations/implicationsThis paper enriches the understanding of NEILEs' transnational entrepreneurial behavior in the era of digital economy. The theoretical contribution of this paper is that the authors build a theoretical framework based on the logical starting point, the logical fulcrum and the logic ending point for understanding the rapid internationalization of NEILEs.Practical implicationsThis study demonstrates that NEILEs can also expand into foreign markets according to their own characteristics. Undoubtedly, they need to choose appropriate internationalization target mode and international market entry way in line with the extent and duration of their losses, and their advantageous slack resources.Originality/valueIn this paper, the authors construct the rapid internationalization theory of NEILEs based on the dual situation of negative attainment discrepancy and advantageous slack resources in digital economy era. Moreover, the authors discover the behavioral characteristics and patterns of NEILEs' transnational entrepreneurship.