bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties
Authors: Sargis Timothy , Youn Seock-Won , Thakkar Krishna , Naiche L. A. , Paik Na Yoon , Pajcini Kostandin V. , Kitajewski Jan K. 
Published: November 2022

AbstractThe Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notch1 extracellular domain, called Notch decoys, which bound ligands, blocked Notch signaling, and showed anti-tumor activity with low toxicity. However, the study of their function depended on virally mediated expression, which precluded dosage control and limited clinical applicability. We have refined the decoy design to create peptibody-based Notch inhibitors comprising the core binding domains, EGF-like repeats 10–14, of either Notch1 or Notch4. These Notch peptibodies showed high secretion properties and production yields that were improved by nearly 100-fold compared to previous Notch decoys. Using surface plasmon resonance spectroscopy coupled with co-immunoprecipitation assays, we observed that Notch1 and Notch4 peptibodies demonstrate strong but distinct binding properties to Notch ligands DLL4 and JAG1. Both Notch1 and Notch4 peptibodies interfere with Notch signaling in endothelial cells and reduce expression of canonical Notch targets after treatment. While prior DLL4 inhibitors cause hyper-sprouting, the Notch1 peptibody reduced angiogenesis in a 3-dimensional in vitro sprouting assay. Administration of Notch1 peptibodies to neonate mice resulted in reduced radial outgrowth of retinal vasculature, confirming anti-angiogenic properties. We conclude that purified Notch peptibodies comprising EGF-like repeats 10–14 bind to both DLL4 and JAG1 ligands and exhibit anti-angiogenic properties. Based on their secretion profile, unique Notch inhibitory activities, and anti-angiogenic properties, Notch peptibodies present new opportunities for therapeutic Notch inhibition.
Semantic Factorization and Descent
Authors: Lucatelli Nunes Fernando 
Published: November 2022

AbstractLet $${\mathbb {A}}$$
A
be a 2-category with suitable opcomma objects and pushouts. We give a direct proof that, provided that the codensity monad of a morphism p exists and is preserved by a suitable morphism, the factorization given by the lax descent object of the two-dimensional cokernel diagram of p is up to isomorphism the same as the semantic factorization of p, either one existing if the other does. The result can be seen as a counterpart account to the celebrated Bénabou–Roubaud theorem. This leads in particular to a monadicity theorem, since it characterizes monadicity via descent. It should be noted that all the conditions on the codensity monad of p trivially hold whenever p has a left adjoint and, hence, in this case, we find monadicity to be a two-dimensional exact condition on p, namely, to be an effective faithful morphism of the 2-category $${\mathbb {A}}$$
A
.
Spatial Variability of Nocturnal Stability Regimes in an Operational Weather Prediction Model
Authors: Kähnert Marvin , Sodemann Harald , Remes Teresa M. , Fortelius Carl , Bazile Eric , Esau Igor 
Published: November 2022

AbstractForecast errors in near-surface temperatures are a persistent issue for numerical weather prediction models. A prominent example is warm biases during cloud-free, snow-covered nights. Many studies attribute these biases to parametrized processes such as turbulence or radiation. Here, we focus on the contribution of physical processes to the nocturnal temperature development. We compare model timestep output of individual tendencies from parametrized processes in the weather prediction model AROME-Arctic to measurements from Sodankylä, Finland. Thereby, we differentiate between the weakly stable boundary layer (wSBL) and the very stable boundary layer (vSBL) regimes. The wSBL is characterized by continuous turbulent exchange within the near-surface atmosphere, causing near-neutral temperature profiles. The vSBL is characterized by a decoupling of the lowermost model level, low turbulent exchange, and very stable temperature profiles. In our case study, both regimes occur simultaneously on small spatial scales of about 5 km. In addition, we demonstrate the model’s sensitivity towards an updated surface treatment, allowing for faster surface cooling. The updated surface parametrization has profound impacts on parametrized processes in both regimes. However, only modelled temperatures in the vSBL are impacted substantially, whereas more efficient surface cooling in the wSBL is compensated by an increased turbulent heat transport within the boundary layer. This study demonstrates the utility of individual tendencies for understanding process-related differences between model configurations and emphasizes the need for model studies to distinguish between the wSBL and vSBL for reliable model verification.
The ethical night of libertinism: Beauvoir’s reading of Sade
Authors: Foultier Anna Petronella 
Published: November 2022

AbstractThis paper examines Simone de Beauvoir’s reading of the eighteenth century writer and libertine Marquis de Sade, in her essay “Must we Burn Sade?”; a difficult and bewildering text, both in pure linguistic terms and philosophically. In particular, Beauvoir’s insistence on Sade as a “great moralist” seems hard to reconcile with her emphasis, inThe Ethics of Ambiguity, on the interdependency of human beings and her exhortation to us to promote other people’s freedom, as well as the aspiration ofThe Second Sexto equal relations between the genders. While earlier scholars addressed the ethico-political implications of Beauvoir’s essay, they insisted that the ambiguity so fundamental in her philosophy is denied by the Sadean hero, and that the Other can never be attained in his system. In this essay, I argue that Sade paradoxically emerges as an ethical model in Beauvoir’s text: as a writer, he assumes the ambiguity of the human condition in the extreme. Further, Sade reveals the potential of sexuality if it is explored in a form of eroticism that largely transgresses behavior constructed as normal: his writings open up new forms of existence, where, contrary to prevailing ideas, woman’s sexual freedom is claimed as equal to man’s, where genders are unstable and heterosexuality no longer the standard. Beauvoir’s fascination with Sade in this essay can be linked with the seemingly unresolvable asymmetry in the relation between men and women inThe Second Sex: in his writings is revealed sexuality’s potential to subvert patriarchal norms and mystifications, and perhaps, in the end, even gender itself.
‘Windows of opportunity’: exploring the relationship between social media and plastic policies during the COVID-19 Pandemic
Authors: Vince Joanna , Praet Estelle , Schofield John , Townsend Kathy 
Published: November 2022

AbstractPlastic pollution has reached a crisis point due to ineffective waste management, an over-reliance on single-use plastic items and a lack of suitable plastic alternatives. The COVID-19 Pandemic has seen a dramatic increase in the use of single-use plastics including ‘COVID waste’ in the form of items specifically intended to help stop the spread of disease. Many governments have utilised COVID-19 as a window of opportunity to reverse, postpone or remove plastic policies off agendas ostensibly in order to ‘flatten the curve’ of COVID-19 cases. In this paper, we use novel methods of social media analysis relating to three regions (USA, Mexico and Australia) to suggest that health and hygiene were not the only reasons governments utilised this window of opportunity to change plastic policies. Beyond the influence of social media on the plastics agenda, our results highlight the potential of social media as a tool to analyse public reactions to government decisions that can be influenced by industry pressure and a broader political agenda, while not necessarily following responses to consumer behaviour.
Research patterns in communication (2009–2019): testing female representation and productivity differences, within the most cited authors and the field
Authors: Goyanes Manuel , Demeter Márton , Grané Aurea , Tóth Tamás , de Zúñiga Homero Gil 
Published: November 2022

AbstractThis study compares the share of male/female as first authors, the growth of authors per paper, and the differences in publication productivity in the last decade of the most cited authors versus the field of communication (i.e., a representative sample of papers published in the field of communication). Results indicate that there are significantly more female first authors in the field than a decade ago, but their proportion among the most cited authors has not grown at a similar pace. Likewise, the number of authors per paper has significantly increased in the field, but not among the most cited authors, who, in turn, publish significantly more papers than the field, both in 2009 and 2019. And not only that, the productivity gap between the most cited authors and the field has substantially increased between the span of this decade. Theoretical implications of these findings and suggestions for future studies are also discussed.
An efficient privacy-preserving recommender system in wireless networks
Authors: Luo Junwei , Yi Xun , Han Fengling , Yang Xuechao 
Published: November 2022

AbstractRecommender systems have been widely used for implementing personalised content on many mobile online services to reduce computational overload and preserve wireless data for users. The underlying mechanisms used for building recommender systems analyse data collected from users to make recommendations. This poses concerns over the privacy of data from users as both service providers and the cloud will have access. Privacy-preserving recommender systems protect user information by incorporating various cryptographic mechanisms to prevent accessing the data. However, existing works are not practical due to the use of heavy cryptography. In this paper, we propose an efficient privacy-preserving recommender system that takes advantage of clustering to improve efficiency. Using a secure clustering mechanism, user data are assigned to multiple clusters before being fed into the recommendation. Our proposed protocols are privacy-preserving and do not leak information that could be used to identify a data subject. The experiments show that our system is efficient and accurate.
Intrinsic anomalous spin Hall effect
Authors: Li Ping , Zhang Jing-Zhao , Guo Zhi-Xin , Min Tai , Wang Xiangrong 
Published: November 2022

AbstractCharge-spin interconversion in magnetic materials is investigated by using the first-principles calculations. In addition to the conventional spin Hall effect (SHE) that requires mutual orthogonality of the charge current, spin-flow direction, and spin polarization, the recently proposed anomalous SHE (ASHE) is confirmed in Mn2Au and WTe2. The interaction of the order parameter with conduction electrons leads to sizeable non-zero spin Berry curvatures that give rise to anomalous spin Hall conductivity (ASHC). Our calculations show that the ASHE is intrinsic and originates from the order-parameter-controlled spin-orbit interaction, which generates an extra anomalous effective field. A useful relationship among the order parameter, the spin Berry curvature, and the ASHC is revealed. Our findings provide a new avenue for generating and detecting arbitrary types of spin currents.
Stress and psychological wellbeing in british police force officers and staff
Authors: Oliver Helen , Thomas Owen , Neil Rich , Moll Tjerk , Copeland Robert James 
Published: November 2022

AbstractInformed by the Demand Resources and Individual Effects model (DRIVE; Mark & Smith, 2008), we assessed how work and individual characteristics were associated with perceived job stress, and psychological wellbeing outcomes (e.g., anxiety, depression, positive mood) in a cross-sectional study with two British police forces (N = 852 officers and staff). Work characteristics predicted psychological wellbeing outcomes both directly and indirectly through the perception of job stress. Work resources and individual characteristics moderated the relationships between work demands, perception of job stress and psychological wellbeing outcomes. The associations between perception of work demands, job stress and psychological wellbeing outcomes were improved in police officers and staff who reported moderate-high physical activity behavior. This study added new knowledge to the domain as it was the first to test the DRIVE model in its entirety in an occupational setting. It also provided new insight into the multi-dimensional factors associated with psychological wellbeing in policing. Practically, the findings implied a reduction of work demands, or interventions that target appraisals and/or physical activity might improve psychological wellbeing in police workers.
Geochemistry and Petrogenesis of Mesoproterozoic Mafic Intrusive Rocks from the Singhora and Chandarpur Groups, Eastern Chhattisgarh Basin, Bastar Craton: Possible Implication for the Time of Sedimentation
Authors: Ashutosh Ankur , Samal Amiya K. , Singh Veeru Kant , Sharma Mukund , Srivastava Rajesh K. 
Published: November 2022

ABSTRACT
A number of Mesoproterozoic mafic intrusions transect the Chhattisgarh basin, Bastar craton, and they are mostly exposed in the Singhora and Chandarpur Group of rocks in the eastern part of the basin. These mafic intrusive rocks are studied for their petrological and geochemical characteristics to understand nature and genesis and likely implication on the time of sedimentation. They chiefly consist of clinopyroxene and plagioclase and show ophitic texture. Geochemically, they are sub-alkaline basalt to basaltic andesite and strongly supports cogenetic nature of mafic intrusives from both the Groups. The fractionation of olivine, clinopyroxene, plagioclase and Cr-spinel primarily controlled geochemical variations. Negative Nb-Ta-Ti anomalies suggest a possible role of crustal components in the evolution of the melt; however, the absence of crustal signature in most primitive high-Mg containing samples rules out any significant role of crustal contamination. Incompatible trace elements modelling suggests their derivation from a mantle melt, originated from the transition zone of garnet-spinel stability field. Further, geochemical analysis supports an SZLM (subduction zone-modified lithospheric mantle) source for these mafic intrusions. Low CaO/MgO (1.20 – 1.64), intermediate FeO/MnO (45.71 – 71.80), positive PX# (1.10 - 5.89), and high values of FC3MS (0.58 – 1.35) and FCKANTMS (0.59 – 0.93) explicitly support derivation of the primary melt from a olivine-poor and pyroxene-rich (pyroxenite type) source. The observed geochemical characteristics and published age data on these mafic intrusions indicate that sediments of both the stratigraphic units are older than ca. 1.42 Ga. Further, based on the relationship with the neighbouring ca. 1.85 Ga Sonakhan mafic dyke swarm of the Bastar craton, the age of sedimentation in the Chhattisgarh basin has been proposed to be in between ca. 1.85 Ga and 1.42 Ga.
Mechanism of Fault Terminations: Theory and Field Examples
Authors: Biswas Madhab , Sain Kalachand 
Published: November 2022

ABSTRACT
Contrary to the mechanism of initiation and growth of a fault that has been extensively addressed, the termination of the fault is poorly understood. It is generally believed that the major factors such as the zone of weakness, frictional homogeneity, rock tension, and the minor factors such as stress and gravity are responsible for the initiation and growth of faults, while the deficiency of these factors leads to the termination of a fault. A theory of fault-termination has been proposed by combining progressive deformation and branching (as observed on seismic data from the North Sea and Scotian basin) along with the hindrance, flanking, block rotation, enhanced mineralization, relaxation and cohesive strength. This model of progressive deformation during faulting is categorized into three zones: displacement zone in the beginning, displacement shear transition zone in the middle and the shear zone towards the termination. These well-patterned changes of progressive deformation include continuation of shearing beyond the tip line and converting brittle displacement deformation state into shearing displacement towards the termination. This mechanism also elucidates the deformation state for blind thrust, brittle-ductile transition zone within the crust, initiation of the reverse fault and deformation-stress relationship for faulting.
Application of the NATM Methodology for the Excavation of Rail Tunnel in Difficult Geological Conditions: A Case from Garhwal Himalaya, Uttarakhand
Authors: Azad Md. Alquamar , Naithani A. K. , Singh S. K. 
Published: November 2022

Abstract
The documentation of excavation method and support design based on rock mass classification systems i.e. rock mass rating (RMR), Q-system and New Austrian tunneling method (NATM) for adit-7 tunnel being constructed in Garhwal Himalaya, India is discussed in this paper. The New Austrian tunneling method classes of rock units have been developed by using correlations with the RMR and Q systems, according to the ONORM B 2203. NATM principles were used because the geological conditions were continually changing. The study indicated that the RMR-based rock mass estimation was overstated, but the qualitative assessment was right. The NATM technique is more adaptable for Garhwal Himalayan rocks having various uncertainties in rock mass evaluation. The current adit investigations indicate that there are numerous unanswered concerns, concerning rock mass quality evaluation, tunnel behavior during construction and usability. Results of the analysis are considered to be useful for the design of the new tunnels constructed in the similar type of the terrain.
Depthwise Variation of Selenium in Groundwater in Parts of Punjab, India
Authors: Angurala M.L. , Naik Pradeep K. , Behera S.C. 
Published: November 2022

ABSTRACT
Selenium is an essential trace element in human diet with carcinogenic effect when consumed in excess. This paper examines the depthwise variartion of selenium in the aquifers of northeastern Punjab (India) in the Indo-Gangetic Plains in a piedmont zone. Out of 210 km2 hydrogeologically studied area in parts of Hoshiarpur and Nawanshahr districts of Punjab State, about 50% of area was found affected by high selenium concentration problem in groundwater. Three aquifer groups were identified, i.e., aquifer group I, II and III with depth ranges of about 75-95 m (thickness ~90 m), 120-230 m (thickness ~110 m) and beyond 255 m, respectively. A clay horizon of about 15-35 m thickness separates aquifer group of I and II and that of about 15-30 m thickness aquifer group of II and III. Aquifer group I is unconfined, aquifer group II is semi-confined and aquifer group III is confined in nature. High concentrations of selenium is observed in aquifer groups I and II with concentrations decreasing with depth. Aquifer group III is devoid of selenium. The symptoms of high contents of selenium started emerging when people deepened their wells in the 1970s to a depth of 20-45 m in a sandy clay horizon. This, however, is yet to be verified and warrants further investigation.
Sedimentology and New Paleogeographic Data of the Lower Eocene Chouabine Formation in the Gafsa Basin (Tunisia), Southern Tethyan Margin
Authors: Messadi Abdel Majid 
Published: November 2022

Abstract
Facies and paleo-environment reconstruction applied to the lower Eocene Chouabine deposits occurring in the Gafsa area in Tunisia provided important information on sediment cyclicity and paleogeographic conditions. From west to east, four sections were surveyed: Tamerza (25 m), Oued Thelja (48 m), Jebel Ong (25 m), and Jebel Chamsi (45 m). Furthermore, the facies stacking pattern allowed for the reconstruction of depositional environments in relation to sea level changes. The Chouabine Formation is formed by the succession of three sequences composed of marls, phosphorites, and carbonates. There are five main facies organized into two transgressive cycles. The gradual transition of facies from intertidal to circatidal environments unraveled the sedimentation on a homoclinal ramp, episodically swept by upwelling currents. The Chouabine Formation is made of deepening–upwards cycles. Each cycle ranges from 2 to 5 m in thickness. The proximal-distal transition of depositional environments was gradually increasing from intertidal to offshore environments. Lateral variation of thickness and facies is generated by the reactivation of inherited NW-SE extensive and/or transtensive faults, acting since the late Cretaceous during the intermediate closing phase of the Neotethys. Synsedimentary tectonics has created trap structures favouring confinement conditions in the center of the basin, permitting the accumulation and preservation of large thicknesses of phosphate deposits. Based on new litho- and biostratigraphic data, this study presents for the first time a clear and detailed regional stratigraphic correlation and paleogeographic maps.
Transfer Learning in Genome-Wide Association Studies with Knockoffs
Authors: Li Shuangning , Ren Zhimei , Sabatti Chiara , Sesia Matteo 
Published: November 2022

AbstractThis paper presents and compares alternative transfer learning methods that can increase the power of conditional testing via knockoffs by leveraging prior information in external data sets collected from different populations or measuring related outcomes. The relevance of this methodology is explored in particular within the context of genome-wide association studies, where it can be helpful to address the pressing need for principled ways to suitably account for, and efficiently learn from the genetic variation associated to diverse ancestries. Finally, we apply these methods to analyze several phenotypes in the UK Biobank data set, demonstrating that transfer learning helps knockoffs discover more associations in the data collected from minority populations, potentially opening the way to the development of more accurate polygenic risk scores.