bluuebunny/crossref_metadata_2025_split huggingface dataset:
“The Galaxy Within” on the cover of NeuroImmune Pharmacology & Therapeutics
Authors: Meigs Douglas D. , Johnsen Dustin 
Published: August 2022

Abstract
This letter introduces the cover image of the new open-access journal NeuroImmune Pharmacology and Therapeutics (NIPT). The cover image is titled, “The Galaxy Within”, by Dchordpdx (Dustin Johnsen, Ph.D.). This letter also features additional images by Dr. Johnsen and brief discussion of their relevance to neurodegenerative research. The NIPT journal is now accepting submissions for peer-reviewed publication. Article-processing charges will be waived for all submissions in the journal’s first two years of publication. Unsolicited submissions and contributions to special theme issues are welcome. Submission queries may be addressed to the Editor-in-Chief, Dr. Howard E. Gendelman, with correspondence copied to the journal’s editorial office at nipt@unmc.edu.
The effect of virtual laboratory simulations on medical laboratory techniques students’ knowledge and vocational laboratory education
Authors: Keleş Didem , Bulgurcu Alihan , Feyzioğlu Demir Esra , Şemin Ilgi Makbule 
Published: August 2022

Abstract

Objectives
Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited application options in scientific, medical, and engineering fields. The aim of this study was to evaluate whether VLSs are efficient learning tools and how these simulations can be integrated into laboratory practice in medical laboratory education.

Methods
In this pre-test/post-test control group study, 32 volunteers were randomly assigned to either experimental or control groups. The experimental group performed laboratory simulations based on biochemistry and microbiology and then completed a self-report survey to evaluate their satisfaction and beliefs about simulations.

Results
In the experimental group, post-test scores of each simulation were significantly elevated compared to pre-test scores; however, pre- and post-test scores of control group were statistically the same. The experimental group agreed that these simulations should be applied before theoretical lectures and laboratory practices. They also highlighted that translating from English to their native language creates difficulties in applying and understanding the simulation.

Conclusions
We emphasized that VLSs are excellent learning tools that increase not only the knowledge but also the self-motivation and focus of the students. Based on feedbacks, native language options are necessary to enable the students to achieve equality of opportunity in education.
Turner syndrome and neurofibromatosis type 1: the unusual combination of two common genetic disorders
Authors: Vieira Inês , Lopes Sofia , Bastos Margarida , Ruas Luísa , Rodrigues Dírcea , Paiva Isabel 
Published: August 2022

Summary
The coexistence of neurofibromatosis type 1 (NFT1) and Turner syndrome (TS) has only been reported in a few patients and may represent a diagnostic challenge. We describe the case of a 16-year-old girl, with a prior clinical diagnosis of NFT1, who was referred to Endocrinology appointments for the etiological study of primary amenorrhea. Evaluation of the anterior pituitary function was requested and hypergonadotropic hypogonadism was detected. During the etiological study, a 45X karyotype was found and TS was diagnosed. The fact that NFT1 can also be associated with short stature, short broad neck and hypertelorism was likely responsible for TS being diagnosed in late adolescence. As both TS and NFT1 are relatively common genetic disorders, it is important to be alert to the possibility that the presence of one disease does not invalidate the other.

Learning points

The concomitant presence of two syndromes in the same patient is unlikely and represents a diagnostic challenge.

Some phenotypic characteristics and clinical manifestations may be shared by several syndromes.

Some syndromes, such as neurofibromatosis type 1 may have very heterogeneous presentations.

It is important to be alert to the characteristics that are not explained by the initial diagnosis.

If such features are present, diagnostic work-up must be performed regardless of the initial syndromic diagnosis.
Bienestar psicológico y variables sociodemográficas en una muestra de trabajadores y estudiantes universitarios chilenos
Authors: Jorquera Gutiérrez Ricardo 
Published: August 2022

A partir del concepto de Bienestar Psicológico de Carol Ryff (1989), el objetivo del presente estudio fue describir y comparar este constructo en trabajadores de diversas industrias y estudiantes de educación superior. La muestra fue de 415 participantes, seleccionados mediante muestreo de tipo no probabilístico intencional. Del total de la muestra, el 76.9 % (n = 319) fueron trabajadores de industrias y un 23.1 % (n=96) estudiantes de educación superior. Se utilizó la Escala de Bienestar Psicológico de Ryff (Diaz et ál, 2006) en su versión adaptada. Se encontraron diferencias significativas entre trabajadores y estudiantes. Las mayores diferencias se observan al comparar la muestra según ingresos familiares. Según el sexo y la edad solo se encuentran diferencias en el componente de relaciones positivas. Es posible concluir respecto al importante papel del trabajo sobre el bienestar psicológico y de cómo este varía de acuerdo a las condiciones socioeconómicas del trabajador y del rubro en el cual se desempeña.
La aplicación del valor razonable en Costa Rica: un estudio exploratorio
Authors: Sosa Mora Eduardo 
Published: August 2022

Este artículo presenta los resultados de un estudio realizado con base en los estados financieros auditados al 31 de diciembre de 2020, de 33 empresas y entidades costarricenses, con el propósito fundamental de explorar en qué medida aplican el modelo de valor razonable. Dada su naturaleza exploratoria, este trabajo pretende aportar información significativa para futuras investigaciones, más que inferir sus resultados a la población de empresas costarricenses.
El estudio permitió evidenciar que el modelo de valor razonable se encuentra en una etapa incipiente en Costa Rica. No es la principal base de medición contable en las entidades estudiadas y se emplea, primordialmente, en la medición de activos financieros, en entidades financieras y empresas no financieras. Su uso para valorar activos no financieros se limita a la revaluación de bienes inmuebles, así como a la medición de propiedades inmobiliarias principalmente con propósitos informativos, lo cual contrasta con el auge del modelo en las Normas Internacionales de Información Financiera, pero concuerda con los resultados de estudios similares realizados en varios países de América Latina.
Implementation and Evaluation of Preimplantation Genetic Testing at Vilnius University Hospital Santaros Klinikos
Authors: Stukaitė-Ruibienė Eglė , Gudlevičienė Živilė , Amšiejienė Andrė , Dagytė Evelina , Gricius Rimantas , Grigalionienė Kristina , Utkus Algirdas , Ramašauskaitė Diana 
Published: August 2022

Background and Objectives: The most effective treatment of infertility is in vitro fertilization (IVF). IVF with Preimplantation Genetic Testing (PGT) allows to identify embryos with a genetic abnormality associated with a specific medical disorder and to select the most optimal embryos for the transfer. PGT is divided into structural rearrangement testing (PGT-SR), monogenetic disorder testing (PGT-M), and aneuploidy testing (PGT-A). This study mostly analyzes PGT-SR, also describes a few cases of PGT-M. The aim of this study was to implement PGT procedure at Vilnius University Hospital Santaros Klinikos (VUHSK) Santaros Fertility Centre (SFC) and to perform retrospective analysis of PGT procedures after the implementation.Materials and Methods: A single-center retrospective analysis was carried out. The study population included infertile couples who underwent PGT at SFC, VUHSK from January 01st, 2017 to December 31st, 2020. Ion PGM platform (Life Technologies, USA) and Ion ReproSeq PGS View Kit (Life Technologies, USA) were used for the whole genome amplification. Results were assessed using descriptive statistics.Results: PGT was successfully implemented in VUHSK in 2017. During the analyzed time period, thirty-four PGT procedures were performed for 26 couples. Two procedures were performed in 2017, 7 procedures – in 2018, 13 – in 2019, and 12 – in 2020. In comparison with all IVF procedures, 2.5% procedures were IVF with PGT, a highest percentage was in 2020 (3.8% of all procedures). The main indication for PGT was balanced chromosomal rearrangements (in 85.3% cases). In all 34 cases 515 oocytes were aspirated in total, 309 oocytes were fertilized, oocytes fertilization rate exceeded 60%. A normal diploid karyotype was found in 46 (16.8%) biopsied embryos. Out of all PGT procedures, 9 (26.5%) resulted in a clinical pregnancy. Six (66.7%) pregnancies were confirmed in 2019, and 3 (33.3%) – in 2020. Three (33.3%) pregnancies resulted in spontaneous abortion, 6 (66.7%) – in delivery.Conclusions: The implementation of PGT in VUHSK was successful. The most common indication for PGT was a reciprocal translocation. Oocytes fertilization rate exceeded 60%, a normal karyotype was found less than in one-fifth of biopsied embryos. A highest clinical pregnancy rate was achieved in 2019 when almost half of women conceived, which is probably related to the experience gained by the multidisciplinary team. This is the first study analyzing IVF with PGT in Lithuania, however, the results should be interpreted with caution due to a low number of total procedures performed.
Testosterone protects cardiomyocytes against hydrogen peroxide-induced aging by upregulating IGF1 and SIRT1 pathways
Authors: Yan Li , Nong Xiting , Deng Jizhao , Yang Guang 
Published: August 2022

Abstract

Objective
To investigate the role of IGF1 and SIRT1 pathways in protection of hydrogen peroxide (H2O2)-induced aging in H9c2 rat cardiomyocyte cells by testosterone.

Methods
The cells were treated with testosterone or up- or down-regulated for the IGF1 and SIRT1 genes and assessed for apoptosis, aging and expression of relevant genes.

Results
Aging was induced and the expression of SIRT1 and IGF1 was down-regulated after H2O2 treatment in H9c2 cells. The aging was attenuated in a dose-dependent manner after the cells were exposed to testosterone. Down-regulation of SIRT1 and IGF1expression was offset in the H2O2-treated cells co-treated with testosterone. Up- or down-regulation of IGF1 significantly reduced or increased senescence-associated beta-galactosidase (SA-β-gal) cells and the ROS level, respectively. In addition, SIRT1 expression was regulated by IGF1 expression. Down- or up-regulation of SIRT1 significantly decreased or increased the IGF1 levels, respectively. Furthermore, after IGF1 and SIRT1 knockdown, testosterone did not protect the cells from senescence. Testosterone, and overexpression of IGF1 and SIRT1 also up-regulated the expression of the fetal genes SERCA2 and MYH6 and down-regulated the expression of the ACTA1 and MYH7 genes.

Conclusions
Our data indicate that testosterone can attenuate cardiomyocyte aging induced by H2O2 and up-regulate SIRT1 and IGF1. The IGF1and SIRT1 pathway may be new targets to treat heart aging and heart failure.
Media Rituals in Eusébio’s Exequies
Authors: Mateus Samuel 
Published: August 2022

While celebrating collective representation, the media can be seen as spaces of ritualization that are fundamental to the consolidation of wider social values.
In this paper we give an empirical frame to the concept of “media rituals” considering it as an entrenched symbolic practice that could be traceable in Eusébio’s exequies television broadcasting. Three sorts of media rituals are identified: rituals dealing with immediacy, rituals dealing with collective prominence and rituals dealing with the revelation of reality.
Each media ritual exemplifies how a space of comprehensive ritualization is erected. It is through this generalized and mediated ritualization that the idea of a major social occurrence is refreshed and worked through.
Esfera pública, Tecnologia e Reconfiguração da Identidade Individual
Authors: Serrazina Filomena 
Published: August 2022

O objectivo deste trabalho é reflectir sobre a relação entre tecnologias de informação e comunicação, esfera pública e esfera privada, questionando se a hipertrofia do indivíduo que decorre da modernidade está ou não directamente relacionada com a “queda do homem público”. Partindo da constatação de que o actual sistema político democrático sofre de um deficit de participação, as tecnologias de informação e comunicação são identificadas como o primeiro requisito necessário à participação, embora reconhecendo os factores de exclusão associados a essas mesmas tecnologias. A literacia digital é identificada como o segundo requisito, representando a passagem da esfera do “poder participar” para a esfera do “saber participar”. A partir destas duas vertentes, verifica-se a emergência de um outro problema ligado à participação, a saber, a ausência de vontade individual para essa mesma participação. Para contrariar a tendência de afastamento dos indivíduos face ao bem comum, é enfatizado o papel da comunicação, da linguagem e, por inerência, dos próprios media, bem como o surgimento de outras dinâmicas de participação relacionadas com ambientes informais, que deve ser valorizado e estimulado. Considerando que a participação cívica extravasa as dimensões tecnológica e educacional, conclui-se pela necessidade de adoptar políticas concertadas de envolvimento, construção de identidades, integração e responsabilização dos indivíduos
que permitam fazer corresponder à reconfiguração dos indivíduos na sociedade, uma reconfiguração da própria esfera pública e por inerência, promovam uma maior participação democrática.
Journalistic (self)-criticism: Effect of convergence managerial strategies on journalistic representations
Authors: Degand Amandine 
Published: August 2022

This article addresses the issue of convergence through the lens of journalistic views. How do journalists perceive the organizational innovations that they need on a daily basis? One of the objectives of this research is to evaluate the effect of various managerial strategies (integration, involvement, economic strategies) on journalist representations.
We present the results of an extensive ethnographic survey conducted between the end of 2009 and the beginning of 2010, in 11 newsrooms of French-speaking Belgium. During this survey, 101 interviews with journalists were gathered. We applied a thematic analysis to this extensive empirical material (Paillé and Mucchielli, 2003) and descriptive counts by cross-tabulation with the Nvivo software.
This method shows that some strategic options have managed to improve the consideration of Web teams or weaken some resistance towards collaborative work with the Web. However, whether working online or offline, journalists appear particularly critical in regard to Webjournalism. All of them keep their distance from Web team work, which is overwhelmingly considered unrewarding.
This intense criticism by journalists is interpreted as one of the main drivers of the permanent reshaping of journalism, on two levels. Firstly, criticism is a possible fulcrum for editorial reorganization. It is by taking into account journalistic criticism that the management can establish convergence according to methods that will be judged more balanced by the journalists concerned. Secondly, criticism is a node that allows the issue of identity to be addressed. Once integrated and implemented in a dialog process, criticism indeed allows journalists to rethink and constantly reassess the reasons for their commitment to their profession.
Public Aid as a Measure of State Interventionism in the Portuguese and Spanish Press
Authors: Magallón-Rosa Raúl , Aguado-Guadalupe Guadalupe , Sanmartí-Roset José María 
Published: August 2022

The aim of this paper is to analyze the communication policies and the relationships between State and Press in the case of Portugal and Spain, with special emphasis on the particular characteristic of both countries within the Euro-Mediterranean model release. It also makes a historical approach in order to explain what was the context and measures over the years that have led to the current reality in the Iberian countries.
In view of the paradigm shift that digital convergence is bringing about, it raises some reflections on how these countries - with a very definite journalistic tradition, is facing the future of the press. Among other reasons because there is no guarantee that government measures of the past be able to ensure in the future the competitive vitality required under the international convergence of media. It is necessary as well to review how the various policies of aid and impact assessments contribute to paralysis in decision-making.
Rumores do fim do mundo e o papel dos media. O caso de 21 de Dezembro de 2012
Authors: Sena Ana Margarida 
Published: August 2022

Provavelmente a mais mediatizada data sobre o fim dos tempos foi a recente “profecia” de 21 de dezembro de 2012.
Hoje em dia os rumores espalham-se rapidamente e globalmente. Os meios de comunicação social funcionam como acelerador, e acabam por legitimar este tipo de fenómenos.
Trata-se de um caso que nos faz meditar sobre a noção de “fim dos tempos” e sobre os desafios de uma sociedade em mutação. Permite-nos também debruçar sobre o papel dos meios de comunicação na propagação dos rumores e os seus efeitos.
A ecrãcultura emergente nas vivências dos jovens portugueses: poderá falar-se de uma geração de ecrãs?
Authors: Melro Ana , Silva Lídia Oliveira da 
Published: August 2022

O ritmo elevado da utilização das tecnologias e a apropriação dos media de forma transversal e ubíqua permitiram a propagação de vários termos que se generalizaram, uma vez que também se propagaram os media e as suas potencialidades. Este fenómeno contemporâneo desafia a comunidade científica a observar e a refletir no sentido de compreender os processos sociais e comunicacionais em curso.
A referência aos novos media quase não pode ser dissociada da geração que proporcionou a sua utilização massiva. Assim, neste artigo, reflete-se sobre a apropriação dos novos media e, consequentemente, de ecrãs por indivíduos com idades compreendidas entre os 21 e os 45 anos de idade, e a integração dos artefactos tecnológicos nos variados contextos onde passam o seu tempo: na escola, no espaço familiar e nos períodos de lazer.
Apresentam-se os resultados obtidos através da aplicação de um inquérito por questionário no ano letivo de 2011/2012 a 30 alunos do 3º ano da licenciatura em Novas Tecnologias da Comunicação, na unidade curricular de Cibercultura, da Universidade de Aveiro.
Digital Promotion: the example of the Gorila Vintage Edition
Authors: Sebastião Sonia Pedro , Ruas Tiago Carrapito , Nascimento Ana Catarina , Capelo Ana Rita , Vieira Diogo , Maria Inês Peixoto 
Published: August 2022

This article analyzes the campaign Gorila Vintage, developed by the advertising agency BAR in 2012, with the aim of distinguishing the online promotion from the “traditional” and digital advertising. The intent is to show the limits of advertising and arguing about the advantages of the integration of communication techniques both offline and online in a retrobranding strategy. It is also intended to contribute to the understanding of the practical work of communication professionals, highlighting the difficulties inherent in the creative process, knowledge of the instruments and the budgetary constraints.
In structural terms, the work is divided into three main parts. The first two addresses the concept of advertising, trends, advantages and disadvantages, and the characterization of retrobranding strategy. The last part is a detailed analysis of the Gorila Vintage campaign, using observation and analytical data from the social network facebook, as well as statements from the creative responsible.
Tendencias de uso de YouTube: optimizando la comunicación estratégica de las universidades iberoamericanas
Authors: Guzmán Alba Patricia , Del Moral Maria Esther 
Published: August 2022

Se analizan las tendencias prioritarias del uso de YouTube que hace una muestra de universidades iberoamericanas (N=263) integradas en el Ranking Webometrics, al tiempo que se identifican las oportunidades que esta herramienta les ofrece.
Tras adoptar una metodología descriptiva y multivariante, y proceder al análisis estadístico pertinente de la actividad de las cuentas que tienen las universidades en YouTube, a partir de sus vídeos oficiales, las reproducciones, suscripciones, videos vistos, etc., se comprobó que no sólo poseen varios perfiles y mantienen una gran actividad, sino que se encontraron dos marcadas tendencias de uso: 1) consolidación de su imagen corporativa; y, 2) activación del proceso de comunicación e interacción con los miembros de la comunidad académica.
Sin embargo, se concluye que si bien las universidades apuestan por estar presentes en YouTube -y otras redes- para garantizar su visibilidad y dinamizar la comunicación con su comunidad, precisan arbitrar fórmulas estratégicas más eficaces para gestionar sus perfiles y optimizar su comunicación, las cuales deben pasar por considerar la figura del community manager para incrementar su alcance y prestigio.
La representación de la migración y la figura del Otro en el cine español en la película Poniente (Chus Gutiérrez, 2002)
Authors: Parejo Nekane 
Published: August 2022

Las representaciones de la figura del inmigrante en el cine español habían sido esporádicas hasta el estreno de Las cartas de Alou (Montxo Armendariz, 1990) donde se le concede un papel protagonista. A partir de ahí el cine migratorio español cuenta con una serie de lugares comunes como la inestabilidad laboral, la clandestinidad, la inadaptación, el racismo, etc., que van construyendo el personaje del Otro. Estos aspectos no son nuevos, basta recordar las imágenes cinematográficas de la emigración española durante el franquismo.
Tras un recorrido por las películas que configuran este imaginario se plantean dos cuestiones desde el ámbito cinematográfico: como las nuevas producciones contemplan una mayor variedad y complejidad en las relaciones entre las cada vez más diversas tipologías de pobladores y qué ocurre cuando el país de llegada, España, fue durante décadas el punto de salida de emigrantes. Para dar respuesta a estos interrogantes nos centraremos en la película Poniente (Chus Gutiérrez, 2002) y en las formulas que señala Eric Landowski para relacionarse con el Otro.
Utilização da Internet e do Facebook pelos mais velhos em Portugal: estudo exploratório
Authors: Rebelo Catarina 
Published: August 2022

Embora a crescente centralização nas tecnologias de informação e comunicação e o envelhecimento da população sejam duas das principais tendências sociais, poucos estudos se têm dedicado a analisar a relação da população mais velha com a Internet.
Este artigo foca-se nos utilizadores seniores portugueses da Internet e do Facebook e nos seus interesses e motivações para a utilização destas ferramentas.
Refletindo sobre os fenómenos de exclusão digital, da sociedade em rede e do envelhecimento da população este artigo analisa de que forma as questões de literacia, limitações biológicas associadas à idade e a motivação contribuem para o afastamento dos mais velhos da Internet.
Este artigo é um estudo exploratório de abordagem qualitativa, realizado com quatro seniores residentes da área da grande Lisboa utilizadores da Internet e do Facebook.
Mais do que informação, os mais velhos parecem procurar online acesso a contactos pessoais e às suas memórias. Parece também existir algum desinteresse pelos conteúdos e contornos da tecnologia provavelmente relacionado com a partilha geracional de determinados valores e preferências (Arnoldi & Colombo 2007) que não estão representados na Internet, moldada por gerações com mais literacias digitais.