bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambulatory Glucose Profile According to Different Phases of the Menstrual Cycle in Women Living With Type 1 Diabetes
Authors: Tatulashvili Sopio , Baptiste Julla Jean , Sritharan Nanthara , Rezgani Imen , Levy Vincent , Bihan Helene , Riveline Jean-Pierre , Cosson Emmanuel 
Published: July 2022

Abstract

Context
Some women living with type 1 diabetes complain of changes in glucose values according to the different phases of menstruation.

Objective
To evaluate this variability through continuous glucose monitoring (CGM) data in type 1 diabetes patients.

Design
Observational study.

Setting
Ambulatory data, recruitment in 2 centers in the Paris region.

Patients
Twenty-four women with type 1 diabetes having spontaneous menstrual cycles.

Intervention
Collection of CGM data for 62 spontaneous menstrual cycles, with evaluation of five 3-day phases during each cycle: (1) early follicular (menstruations), (2) mid-follicular, (3) peri-ovulatory, (4) mid-luteal, and (5) late luteal.

Main outcome measure
Time in range (TIR, prespecified).

Results
TIR decreased for each consecutive phase (61 ± 18%; 59 ± 18%; 59 ± 20%; 57 ± 18%; and 55 ± 20%, P = 0.02). The linear mixed model highlighted a decrease in TIR in the mid-luteal (P = 0.03) and late luteal (P &lt; 0.001) phases compared with the early follicular phase. Time above range was significantly higher during the late luteal phase than the early follicular phase (P = 0.003). Time below range was significantly higher during the mid-follicular phase than in the early follicular phase.

Conclusion
In most of the study population, glucose levels rose linearly throughout the menstrual cycle, reaching a maximum in the late luteal phase. A sharp decrease was seen for most participants at the beginning of menstrual bleeding. This should be taken into consideration in daily care of type 1 diabetes patients to avoid hypoglycemia.
A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice
Authors: Kreisman Michael J , McCosh Richard B , Breen Kellie M 
Published: July 2022

Abstract
A major obstacle to monitoring pulsatile luteinizing hormone (LH) secretion in mice has been an assay with sufficient sensitivity in small blood volumes. In 2013, Steyn and colleagues published a highly sensitive enzyme-linked immunosorbent assay (ELISA) that overcame this barrier by coupling a duo of LH antibodies effective in accurately measuring LH in 4-µL whole-blood aliquots. To address the unavailability of the original detection antibody, AFP240580Rb, we validated a replacement detection antibody, biotinylated-5303 SPRN-5, to be used within the established ELISA. This modified LH ELISA demonstrated a minimum detection limit of 0.0028 ng/mL and a limit of quantification of 0.0333 ng/mL or 0.0666 ng/mL in diluted whole-blood samples of volume 6.4 µL (1:10) or 3.2 µL (1:20), respectively. Detection antibody 5303 SPRN-5 demonstrated parallelism, high precision, and accuracy across the standard curve. LH concentrations in comparison assays, using either 5303 SPRN-5 or AFP240580Rb, were highly correlated (R2 = 0.9829) and demonstrated LH pulse profiles from gonadectomized mice that were nearly superimposable. Pulsatile LH secretion was demonstrated in gonad-intact males and diestrous females and basal LH levels measured with 5303 SPRN-5 were approximately 5-fold higher than the limit of quantification. In addition, we document utility of this new LH ELISA to accurately measure LH in whole blood or serum across multiple sampling sites, as well as in pituitary extracts, LβT2 cells, or media. In summary, the modified LH ELISA described here is highly effective in measuring LH across a range of sample types and small volumes in mice.
Influence of weighted downhill running training on serial sarcomere number and work loop performance in the rat soleus
Authors: Hinks Avery , Jacob Kaitlyn , Mashouri Parastoo , Medak Kyle D. , Franchi Martino V. , Wright David C. , Brown Stephen H. M. , Power Geoffrey A. 
Published: July 2022

ABSTRACT
Increased serial sarcomere number (SSN) has been observed in rats following downhill running training due to the emphasis on active lengthening contractions; however, little is known about the influence on dynamic contractile function. Therefore, we employed 4 weeks of weighted downhill running training in rats, then assessed soleus SSN and work loop performance. We hypothesised trained rats would produce greater net work output during work loops due to a greater SSN. Thirty-one Sprague-Dawley rats were assigned to a training or sedentary control group. Weight was added during downhill running via a custom-made vest, progressing from 5–15% body mass. Following sacrifice, the soleus was dissected, and a force-length relationship was constructed. Work loops (cyclic muscle length changes) were then performed about optimal muscle length (LO) at 1.5–3-Hz cycle frequencies and 1–7-mm length changes. Muscles were then fixed in formalin at LO. Fascicle lengths and sarcomere lengths were measured to calculate SSN. Intramuscular collagen content and crosslinking were quantified via a hydroxyproline content and pepsin-solubility assay. Trained rats had longer fascicle lengths (+13%), greater SSN (+8%), and a less steep passive force-length curve than controls (P&lt;0.05). There were no differences in collagen parameters (P&gt;0.05). Net work output was greater (+78–209%) in trained than control rats for the 1.5-Hz work loops at 1 and 3-mm length changes (P&lt;0.05), however, net work output was more related to maximum specific force (R2=0.17-0.48, P&lt;0.05) than SSN (R2=0.03-0.07, P=0.17-0.86). Therefore, contrary to our hypothesis, training-induced sarcomerogenesis likely contributed little to the improvements in work loop performance.
This article has an associated First Person interview with the first author of the paper.
Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial
Authors: Abdullah Murdani , Pawitan Jeanne Adiwinata , Irawan Cosphiadi , - Rahyussalim , Aditianingsih Dita , Liem Isabella Kurnia , Sinto Robert , Susilo Adityo , Yulianti Mira , Handayani Raden Rara Diah , Pratomo Irandi Putra , Burhan Erlina , Damayanti Triya , Wibowo Heri , Dilogo Ismail Hadisoebroto , Muliawan Hary Sakti , Elhidsi Mia 
Published: July 2022

Background: Mesenchymal stem cells (MSCs) are known to have immunomodulatory, anti-inflammatory, anti-apoptotic, and angiogenesis effects that are useful for relieving inflammation, recovery, and protection of lung tissues in COVID-19 patients. Secretome, a secretory product of MSCs, has several advantages over MSCs. We conducted a study to investigate secretomes’ effectiveness and safety profile as a treatment for severe COVID-19. Methods: A double-blind, multicenter, randomized, placebo-controlled trial was conducted between February 2021 and July 2021 in three top COVID-19 referral hospitals in the Greater Jakarta area, Indonesia. Eligible subjects (n=40) were randomized in a 1:1 ratio to an intervention group (n=20) and a control group (n=20). The primary outcome of this study was the changes in inflammatory markers and the ratio of inflammatory to anti-inflammatory markers. The secondary outcomes of this study included clinical outcome, laboratory outcome, radiological outcome, RT-PCR result conversion, and safety profile of MSC secretome. Results: Our analysis showed that on the 14th day after placebo administration, IL-6 level in the control group was significantly increased [4.110 (2.403–12.820) at baseline to 13.320 (2.958–33.285) on the 14th day after intervention, p=0.017]. The IL-6/IL-10 ratio in the control group was significantly increased (p=0.036) on the 14th day after placebo administration. We also found that most of the subjects who received placebo had high levels of IL-6 and ferritin (p=0.043) on the seventh day after the intervention. However, we found no significant differences in inflammatory marker levels on the seventh day and 14th day after intervention between both groups. There was no adverse event reported. There were no significant differences in the laboratory outcome, radiology outcome, RT-PCR result conversion, and safety profiles between both groups. Conclusions: MSC secretome can control inflammation in patients with severe COVID-19 and has a good safety profile. MSC secretome is a promising treatment modality for severe COVID-19.
Psychomotor performance in video games
Authors: Horoszkiewicz Krzysztof , Horoszkiewicz Bartosz , Załęski Grzegorz 
Published: July 2022

Introduction: Interactive electronic games allow to access virtual environments and interact using a computer or TV screen. Anyone who has played a video game, or seen others playing, is aware of the importance of reaction speed and eye-hand coordination skills.
Objective: To determine the differences in psychomotor performance between professional gamers and amateurs.
Material and Methods: A total of 62 gamers took part in the study, including 31 people - professional video game users who had participated in e-tournaments in the last month (age: M = 20.6, SD = 6.3) and 31 people who did not play video games or played very rarely (they declared that they did not participate in e-sports tournaments), who constituted the control group (age: M = 17.9, SD = 5.4). Integrated computer SDP-System with an executive module for stimulus generation and reception was used to assess psychomotor performance.
Results: Professional gamers have higher psychomotor skills than amateurs. They reveal better results for fast thinking, motor reactions, perception, attention, and working memory.
Conclusion:
Playing video games has a positive impact on players' psychomotor performance and can promote improvements in elementary cognitive functions.
Key words: video-games; e-sport; psychomotor performance; cognitive functions
Optimizing Soil Moisture Sensor Depth for Irrigation Management Using Universal Multiple Linear Regression
Authors: Clutter Melissa , DeJonge Kendall 
Published: July 2022

HighlightsUniversal multiple linear regression (uMLR) was used to optimize soil moisture sensor depth.Eight years of soil moisture data from various water treatments were tested, then validated.The best single observation depth for irrigation management is at 30 cm below soil surface.A single calibrated soil moisture sensor may be used to aggregate soil water deficit in the root zone.Abstract. Soil moisture sensors are valuable tools in irrigation management, but due to soil spatial variability it is challenging for point-based sensors to characterize the entire soil water profile. Universal multiple linear regression (uMLR) is a simple machine learning tool that analyzes the relationship between all possible subsets of observations and the prediction of interest. This study used uMLR and volumetric water content data (VWC) taken from maize field experiments at the Limited Irrigation Research Farm near Greeley, Colorado, to optimize the number and placement of soil moisture sensors to characterize the entire soil water deficit (SWD) in the root zone. The uMLR analysis quantified the accuracy of using one or two VWC measurements to represent SWD. We evaluated seven field seasons, with 12 treatments and four replicates of each, where volumetric VWC was typically measured one to three times weekly. Results indicate that the best single sensor depth is at 30 cm, and the best combination of two sensors is at 0 to 15 cm and 60 cm. To validate the experiment, a continuous VWC sensor was used at 30 cm to predict SWD results with acceptable accuracy (RMSE = 4.60 mm). This study suggests that in the sandy loam site evaluated and with varying irrigation levels, soil moisture sensor placement near the soil surface along with knowledge of soil texture can be used to characterize SWD. This technique may be transferable to other locations and soils and shows potential for optimizing irrigation management via soil moisture sensor networks with continuous SWD data. Keywords: Deficit irrigation, Machine learning, Soil moisture sensor, Soil water deficit, Universal multiple linear regression, Volumetric water content.
Energy-efficient bandwidth enhancement of Brillouin microwave photonic bandpass filters
Authors: Raj Piyush , Parihar Reena , Dhawan Rajveer , Choudhary Amol 
Published: July 2022

Stimulated Brillouin scattering has been widely utilized to realize frequency-agile narrowband and wideband microwave photonic bandpass filters by primarily utilizing its gain response. However, most demonstrated wideband Brillouin-based filters are limited in operation due to the high-power requirements for bandwidth tailoring. We propose a novel approach to realize wideband reconfigurable, Brillouin-based microwave photonic bandpass filters employing RF interferometry and advanced phase engineering. Demonstrated filters exhibit >20 dB selectivity and >700 MHz bandwidth using only 8 dB peak SBS gain (of intrinsic linewidth 30 MHz), and total optical pump power of only ∼14 dBm. We also demonstrate frequency tunability up to 22 GHz. The filter passband has a very flat and highly linear phase response, thus exhibiting zero group delay which we have experimentally verified by propagating an RF pulse at 10.25 GHz. Furthermore, the filter does not suffer from added Brillouin noise in the passband, which is a major advance compared to conventional Brillouin-based microwave photonic sub-systems. This paper presents simulations, mathematical analysis, and experimental results of the proposed filter. The proposed filter demonstrates a pathway toward power-efficient Brillouin-based microwave photonic filters, utilizing SBS responses, in combination with phase manipulation for advanced filtering operations.
A rare presentation of type II Abernethy malformation and nephrotic syndrome: Case report and review
Authors: Wu Xin , Gu Weizhong , Lin Yongzhi , Ye Lina 
Published: July 2022

Abstract
Type II Abernethy malformation is an extremely reported congenital extrahepatic portosystemic shunt in complication with nephrotic syndrome. We present the case of an 8-year-old boy who presented with symptoms of type II Abernethy malformation and nephrotic syndrome. This diagnosis of this type II Abernethy malformation was based on physical examination, blood tests, urinalysis, nephrotic and hepatic function tests, routine clinical lipid measurements, abdominal ultrasonography, and computed tomographic angiography. A kidney biopsy revealed the pathological features of nephrotic syndrome. This is the second reported patient diagnosed with type II Abernethy malformation and nephrotic syndrome. Captopril treatment was effective in improving the symptoms of this case. A patient with type II Abernethy malformation related to immune complex-mediated glomerular injury was effectively improved with medication. Type II Abernethy malformation is a causative factor of immune complex-mediated glomerular injury in nephrotic syndrome. Captopril treatment significantly improved the symptoms in this case.
Some simple biset functors
Authors: Bouc Serge 
Published: July 2022

Abstract
Let 𝑝 be a prime number, let 𝐻 be a finite 𝑝-group, and let 𝔽 be a field of characteristic 0, considered as a trivial

F
⁢
Out
⁢

(
H
)

\mathbb{F}\mathrm{Out}(H)

-module.
The main result of this paper gives the dimension of the evaluation

S

H
,
F

⁢

(
G
)

S_{H,\mathbb{F}}(G)

of the simple biset functor

S

H
,
F

S_{H,\mathbb{F}}

at an arbitrary finite group 𝐺.
A closely related result is proved in the last section: for each prime number 𝑝, a Green biset functor

E
p

E_{p}

is introduced, as a specific quotient of the Burnside functor, and it is shown that the evaluation

E
p

⁢

(
G
)

E_{p}(G)

is a free abelian group of rank equal to the number of conjugacy classes of 𝑝-elementary subgroups of 𝐺.
Application of nonlinear adaptive technology in GPS positioning trajectory of ship navigation
Authors: Dong Haihui , Yin Hui , Xu Qing 
Published: July 2022

Abstract
This article addresses the challenges in the periodic law of high-frequency motion and effectively identifies the influence of high-frequency motion on ship dynamic positioning. The main aim of the article is to design a dynamic positioning filter by applying nonlinear adaptive technology to eliminate the disturbance to the ship’s dynamic propulsion system. This article proposes a method to control the ship’s dynamic positioning and apply nonlinear adaptive technology in the dynamic positioning control in order to obtain the ship’s state and reference coordinate system. Further, a mathematical model and a dynamic environmental model in ship dynamic positioning control are analyzed in this work. The control index model is located by the experimental data, and the control performance is improved within the allowable range. The experimental analysis revealed that if the initial position of the ship is (0, 0, 0), then the desired position is (100, 100, 0). The operating ranges of –0.6 × 107 to 0.6 × 107, –0.4 × 107 to 0.4 × 107, and –5.6 × 108 to 5.6 × 108 are used. The ranges of motion of –150 to 150, –130 to 130, and –5 to 5 are observed, respectively, along with a wind disturbance force of 8 m/s. The wave disturbance force of 1 m/s is observed along with 90° wind. It was observed from the experimentation that the ship could basically achieve a stable operation and control the environmental disturbance within the error range. The outcomes reveal that the proposed dynamic positioning model based on nonlinear adaptive technology has strong stability and accuracy.
Doctus Amyclas. I presagi della tempesta in Luc. 5.539‒560 tra epica, poesia didascalica e retorica
Authors: Campodonico Nicolò 
Published: July 2022

Abstract
In response to Caesar, who intends to reach Antonius in Italy, the boatman Amyclas sets out the celestial and terrestrial signs that foretell a storm and advises against putting out to sea (Luc. 5.539‒560). In this speech Lucan draws on the treatment of such phenomena in the didactic poems of Aratus and Vergil, but the allusions are remodelled in epic language and adapted to the narrative context of the episode. Further, in the story of Amyclas Lucan develops dramatic ideas mentioned in the specific passages in which Aratus and Vergil reflect on the utility of their teachings. Thus the boatman’s meteorological doctrina is highlighted, though he is unable to gain any advantage from it. In fact, in contrast to Palinurus with Aeneas in Aen. 5 and to the rector ratis with Pompey in Luc. 8, Amyclas does not try to dissuade Caesar from the voyage and agrees to accompany him. His speech shows affinities with declamations on the theme of sailing and the presence of adverse omens; however, the speech of Amyclas sounds like a suasoria that has been interrupted. This aspect focuses the impossibility of communication between the two characters: Amyclas, powerlessly external to the civil wars, can only appeal to the force of nature, which Caesar impiously defies.
Kinetic Responses to External Cues Are Specific to Both the Type of Cue and Type of Exercise in Adolescent Athletes
Authors: Barillas Saldiam R. , Oliver Jon L. , Lloyd Rhodri S. , Pedley Jason S. 
Published: July 2022

Abstract
Barillas, SR, Oliver, JL, Lloyd, RS, and Pedley, J. Kinetic responses to external cues are specific to both the type of cue and type of exercise in adolescent athletes. J Strength Cond Res 37(3): 597–605, 2023—The purpose of this study was to examine how external cues influence kinetics during isometric and dynamic tasks in adolescent athletes. Fifteen adolescent male soccer players performed an isometric midthigh pull (IMTP), unloaded and loaded squat jumps (SJs) (15 and 30% of body mass), countermovement jump (CMJ), and drop jump (DJ) using a neutral or external force-specific or velocity-specific cues. Cue type had limited effects on outcomes in the IMTP or SJs, with mostly trivial (g < 0.20), nonsignificant differences (p > 0.05) across kinetic variables. In the CMJ and DJ, a force cue significantly (p < 0.05) increased jump height (g = 0.43 & 0.52) compared with a velocity cue, but in the DJ, a force cue significantly increased jump height (g = 0.52) compared with both a neutral and velocity cue. However, a velocity cue significantly (p < 0.05) reduced ground contact time (g = 0.73–1.52) and time to peak force (g = 0.50–1.29) in both the CMJ and DJ when compared with a force and neutral cue and increased force and power-related measures (g = 0.33–1.12) in the CMJ and DJ when compared with a force cue. In adolescent athletes, the type of external cue had limited effects on kinetic measures in an IMTP and SJ but differential effects on both a CMJ and DJ, suggesting cues have more effect with increasing movement velocity. Consequently, practitioners working with adolescent athletes should consider both the type of exercise and the desired outcome when providing external cues.
Effects of Silica Fume Purity on Behavior of Ultra-High Performance Concrete
Authors: Carey Ashley S. , Howard Isaac L. , Shannon Jay 
Published: July 2022

AbstractThe use of silica fume in high-strength and ultra-high performance concretes has been studied from many perspectives including optimum replacement rate, implications on late-age strengths, and rheological properties. However, the effects of silica fume purity (e.g., silicon dioxide [SiO2] content) are not nearly as well documented, especially when shorter duration curing regimes at higher temperatures are utilized. In this paper, four silica fumes with varying SiO2 contents were used to quantify the effects of SiO2 purity in silica fume on the behavior of ultra-high performance concrete. Several variables were evaluated to determine if changes in SiO2 content significantly influenced properties of interest. Overall, silica fume purity had the most impact on thermal set time, maximum temperature generated during hydration, and compressive strength. Thermal set time values differed by over 7 h, and maximum temperatures differed by 7°C. After one day of room-temperature curing, compressive strength varied by 50 MPa, and elastic modulus varied by 14 GPa. When specimens were cured at elevated temperatures for short durations of time (e.g., one to six days), fc values ranged from 35 to 47 MPa.
The Effects of Electroless Ni-P Coated SiC on the Properties of Magnesium Composite
Authors: Muraliraja R. , Pradeepkumar K. , Mohanraj P. , Vinod Kumar T. , Dhanasekaran C. , Chandrasekaran M. , Ragavanantham S. , Shaisundaram V. S. 
Published: July 2022

Abstract
Reuse of magnesium alloy is an essential approach to protecting the natural resources, and it eliminates the waste products dumped in landfills, water, and air. Therefore, the first time the scrap magnesium alloy materials are collected and fabricated, the newly formulated magnesium composites use different techniques, such as vacuum, squeeze, and stir casting. AZ91 alloy from the automobile scrap is used as matrix material, and silicon carbide (SiC) is used as reinforcement. Electroless nickel-phosphorous coating is applied to the ceramic particles to avoid unwanted chemical reactions during the casting process. The adhesion between the matrix and reinforcement is improved by masking the surface of the nonmetallic SiC particles. Magnesium composite is most commonly used in automotive and aerospace applications to reduce weight and improve the strength of the component. The magnesium composite is fabricated through four different methods, and the substrates are tested and analyzed for better results. The sample results taken from the composites are compared to the magnesium alloy obtained from the scrap stock. Comparatively, the substrate produced using squeeze casting shows a lower porosity level of 5.5 %, and it is clearly shown in optical images. Significant improvements in the mechanical properties, such as hardness and compression strength, are obtained, and the wear rate in the prepared composites is reduced to 28 % for the sample produced using squeeze casting instead of the vacuum and stir casting processes.