bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalensi dan komplikasi pada penderita gagal ginjal kronik yang menjalani hemodialisa di Rumah Sakit Umum Pusat Sanglah Denpasar tahun 2018
Authors: Utami Ida Ayu Ari , Santhi Desak Gede Diah Dharma , Lestari Anak Agung Wiradewi 
Published: December 2022

Background: The prevalence of chronic kidney failure in Australia, Japan and Europe is 6-11%, increased relatively about 5-8% per year. Meanwhile, in Indonesia, the prevalence of chronic kidney failure is 0.2% of total. Only 60% of patients with chronic kidney failure had dialysis therapy.Aim: This study aims to determine the prevalence of patients with chronic kidney failure who do hemodialysis at RSUP Sanglah and to determine the description of complications in patients with chronic kidney failure who do hemodialysis at RSUP Sanglah.Method: This was a categorical descriptive study looking at medical records of chronic renal failure patients do hemodialysis at RSUP Sanglah in 2018 with a sample of 45 patients who had met the inclusion and exclusion criteria. The study sample consisted of chronic kidney failure patients do hemodialysis and complications.Results and conclusion: There were 16 patients with chronic renal failure do hemodialysis at RSUP Sanglah and there were complications consisting of complications of hypertension, hyperuremia, hyperkalemia, metabolic acidosis and anemia. Prevalensi gagal ginjal kronik di negara Australia, Jepang dan Eropa adalah 6 – 11%, terjadi peningkatan 5 – 8% pertahun. Sedangkan, di Indonesia terdapat prevalensi gagal ginjal kronik 0,2% dari penduduk di Indonesia. Hanya 60% dari pasien gagal ginjal kronik yang menjalani terapi dialisis.Tujuan: untuk mengetahui prevalensi pasien gagal ginjal kronik yang melakukan hemodialisis di Rumah Sakit Umum Pusat (RSUP) Sanglah dan untuk mengetahui gambaran komplikasi pada pasien gagal ginjal kronik yang melakukan hemodialisis di RSUP Sanglah.Metode: Penelitian ini merupakan penelitian deskriptif kategorik melihat dari catatan rekam medis pasien gagal ginjal kronik yang menjalani hemodialisis di RSUP Sanglah pada tahun 2018 dengan sampel sebanyak 45 pasien yang telah memenuhi kriteria inklusi dan eksklusi. Sampel penelitian terdiri dari pasien gagal ginjal kronik yang menjalani hemodialisis dan terdapat komplikasi.Hasil dan simpulan: Terdapat 16 pasien gagal ginjal kronik yang menjalani hemodialisis di RSUP Sanglah dan terdapat komplikasi yang terdiri dari komplikasi hipertensi, hiperuremia, hiperkalemia, asidosis metabolik dan anemia.
Koagulopati pada Coronavirus Disease-2019 (COVID-19): Tinjauan pustaka
Authors: Willim Herick Alvenus , Hardigaloeh Amanda Trixie , Supit Alice Inda , Handriyani Handriyani 
Published: December 2022

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 has spread globally and become a new pandemic. Although the clinical manifestation of COVID-19 mainly affected the respiratory system, coagulopathy often occurs in the severe cases and is associated with increased mortality. This literature review aims to provide a review of coagulopathy in COVID-19.Methods: This literature review involved 52 relevant literature about coagulopathy and COVID-19. Different data sources or manual literature search methods used to find articles related to the topic of literature.Results: COVID-19 can trigger cytokine storms and systemic hyperinflammation which cause increased activation of coagulation and resulting in hypercoagulability. Hypercoagulability state in COVID-19 increases the risk of thrombosis and thromboembolism, particularly venous thromboembolism. Prophylactic anticoagulants can prevent thromboembolic events and improve the prognosis of COVID-19 patients with coagulopathy.Conclusion: The hypercoagulation state in COVID-19 can increase the risk of complications from thrombosis and thromboembolism, especially venous thromboembolism. Increased D-dimers are a marker of coagulopathy that is often found in patients with severe COVID-19 and is associated with disease severity. Latar Belakang: Coronavirus disease 2019 (COVID-19) merupakan penyakit infeksi akibat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 telah menyebar secara global dan menjadi pandemi baru. Walaupun manifestasi klinis COVID-19 terutama mengenai sistem respirasi, koagulopati seringkali terjadi pada kasus berat dan berhubungan dengan peningkatan mortalitas. Tinjauan pustaka ini bertujuan untuk memberikan ulasan mengenai koagulopati pada COVID-19.Metode: Tinjauan pustaka ini melibatkan 52 literatur yang relevan tentang koagulopati dan COVID-19. Sumber data yang berbeda atau metode pencarian literatur manual digunakan untuk mencari artikel yang berkaitan dengan topik literatur.Hasil: COVID-19 dapat memicu terjadinya badai sitokin dan hiperinflamasi sistemik yang menyebabkan terjadinya peningkatan aktivasi koagulasi dan mengakibatkan hiperkoagulasi. Keadaan hiperkoagulasi pada COVID-19 meningkatkan risiko terjadinya trombosis dan tromboemboli, terutama tromboemboli vena. Antikoagulan profilaksis dapat mencegah kejadian tromboemboli dan meningkatkan prognosis pada pasien COVID-19 dengan koagulopati.Kesimpulan: Keadaan hiperkoagulasi pada COVID-19 dapat meningkatkan risiko terjadinya komplikasi trombosis dan tromboemboli, terutama tromboemboli vena. Peningkatan D-dimer merupakan penanda koagulopati yang sering ditemukan pada pasien COVID-19 berat dan berhubungan dengan keparahan penyakit.
Hubungan antara status nutrisi dan kualitas hidup pada pasien penyakit ginjal kronik yang menjalani hemodialisis di Rumah Sakit Umum Daerah (RSUD) Wangaya, Denpasar, Bali
Authors: Prabhaswari Lindia , Werdi I Gede Sadu Pratama , Sunaka I Wayan 
Published: December 2022

Background: Quality of life is an important consideration in managing patients with chronic kidney disease (CKD). A number of factors are known to influence Quality of life in a patient with CKD, one of them is nutrition. In this study, we aimed to determine the relationship between nutritional status and Quality of life in CKD patients undergoing hemodialysis. Methods: A cross-sectional analytic study was conducted at Wangaya Regional Hospital, Denpasar, from August to September 2020. Fifty-seven hemodialysis patients were enrolled in this study. Malnutrition Inflammation Score (MIS) and Kidney Disease Quality of Life Short Form-36 (KDQoL SF-36) questionnaires were used to assess nutritional status and Quality of life. Data were analyzed using SPSS software version 20 for Windows, where a p-value of less than 0,05 was considered statistically significant.Results: Of the total 57 subjects, the mean age was 50.12±13.1 years, with 68.4% male. The mean MIS score was 3.05±1.8, while the mean KDQoL score was 73.7±13.4. Pearson test found a significantly strong negative correlation between nutritional status and Quality of life (r=-0,784; p<0,001).Conclusion: There is a significant relationship between nutritional status and Quality of life in chronic kidney disease patients undergoing hemodialysis in Wangaya Regional Hospital, Denpasar. Latar Belakang: Kualitas hidup merupakan hal penting yang harus diperhatikan dalam menangani pasien penyakit ginjal kronik (PGK). Salah satu faktor yang memengaruhi kualitas hidup pasien PGK adalah nutrisi. Penelitian ini bertujuan untuk mengevaluasi hubungan antara status nutrisi dan kualitas hidup pada pasien PGK yang menjalani hemodialisis rutin.Metode: Penelitian ini merupakan penelitian analitik observasional yang dilakukan di RSUD Wangaya Denpasar pada bulan Agustus-September 2020. Subjek penelitian adalah 67 pasien PGK yang menjalani hemodialisis rutin. Instrumen penelitian berupa kuesioner malnutrition inflammation score (MIS) dan kidney disease quality of life short form-36 (KDQoL SF-36). Data yang terkumpul selanjutnya dianalisis dengan menggunakan perangkat lunak SPSS versi 20 untuk Windows dimana nilai p<0,05 dianggap signifikan secara statistik.Hasil: Rerata usia subjek adalah 50,12±13,1 tahun, dengan 68,4% subjek berjenis kelamin laki-laki. Rerata skor MIS subjek adalah 3,05±1,8, sedangkan rerata skor KDQoL adalah 73,7±13,4. Uji korelasi pearson menunjukkan korelasi negatif kuat antara skor MIS dan skor KDQoL (nilai r=-0,784 dan nilai p<0,001). Simpulan: Terdapat hubungan yang signifikan antara status nutrisi dan kualitas hidup pada pasien penyakit ginjal kronik yang menjalani hemodialisis rutin di RSUD Wangaya, Denpasar.
Refractive lens exchange on keratoconus patient: a case report
Authors: Buddyman Ivane Jessica , Pemayun Cokorda Istri Dewiyani , Handayani Ariesanti Tri 
Published: December 2022

Introduction. Keratoconus is a vision disorder that occurs when the cornea becomes thin and irregularly (cone) shaped. Instead of being focused correctly on the retina, this abnormal shape causes the light entering the eye to improperly refracted and manifested as a distortion of vision. Refractive Lens Exchange is one type of Invasive therapy in Keratoconus. Here we describe a case of Keratoconus managed by the Refractive Lens Exchange procedure in our Center.Case Description. A male, 25 years old, visited the clinic due to blurry vision since ten years ago. Every six months or a year, he needs to adjust his lens power. Ophthalmology examination found visual acuity in the right eye was 2/60 PH 6/60, and if using S-9.00, visual acuity improved to 6/30. Meanwhile, visual acuity in the left eye was 1/60 PH 6/60 and if using S–11.75, visual acuity improved to 6/48. Corneal topography supports the finding of Keratoconus. Management for this patient was Refractive Lens Exchange + Intraocular Lens + Capsular Tension Ring. Initially, This advised was differ from the patient expectation, as he wanted a LASIK procedure. An important reminder was given, that Keratoconus is contraindicated for LASIK and any corneal surface ablation procedure. After series of procedure, the VA of the right eye was 6/15 PH 6/6, with C - 4.00 x 1800 VA became 6/6. VA left eye was 6/18 PH 6/9, with C - 4,00 x 1800 VA became 6/9. Binocular vision was 6/6. For near vision, S +3.00 was added for both eyes.Conclusions. Refractive Lens Exchange + Intraocular lens implantation is effective and safe procedures to treat high myopia in keratoconus cornea.
Prevalence of SCCmec Types I, II, III, and pvl gene among Methicillin-Resistant Staphylococcus aureus (MRSA) isolated from clinical specimens in Sanglah General Hospital
Authors: Agastya I Gede Sathya , Darwinata Agus Eka , Pinatih Komang Januartha Putra , Fatmawati Ni Nengah Dwi 
Published: December 2022

Background: Methicillin-Resistant Staphylococcus aureus (MRSA) is a big challenge for health services worldwide which causes infections both in healthcare and community. Healthcare-associated MRSA (HA-MRSA) strains are shown to be resistant to beta-lactam antibiotics and several non-beta lactam antibiotics. At the same time, the community-associated MRSA (CA-MRSA) tends to be resistant to beta-lactam antibiotics. MRSA carried staphylococcal cassette chromosome (SCCmec) types I, II, III, IV, and V. SCCmec types I, II, and III were predominantly found in HA-MRSA strain while SCCmec types IV and V predominantly found in CA-MRSA strains. Furthermore, the panton valentine leukocidine (pvl) gene is commonly found in CA-MRSA strains. Therefore, this study aimed to determine the prevalence of SCCmec types I, II, III, and pvl gene in MRSA isolated from clinical specimens in Sanglah General Hospital.
Methods: This study was a cross-sectional descriptive study. MRSA was isolated from clinical specimens (sputum, wounds, tissue, blood, etc.) from January 2020 to July 2021 and identified by the Vitek 2 Compact (Biomerieux, France) at the Clinical Microbiology Laboratory of Sanglah Hospital. Prevalence of SCCmec and pvl gene using PCR. Data were analyzed using Microsoft Excel version 2010 for Windows.
Results: Most of the specimens (69.56%) were wound. Seventeen (73.91%) out of 23 MRSA isolates were positive for the SCCmec III and pvl gene, while none was positive for the SCCmec I and SCCmec II. About 19 (82.60%) isolates were resistant to two or more non-beta-lactam antibiotics.
Conclusions: The isolates of MRSA in this study were predominantly isolated from wound specimens, with the most prevalent genetic element being SCCmec III. In this study, although most MRSA isolates carried SCCmec III that suggested as HA-MRSA, however, most of the strains harbored the pvl gene. This interesting phenomenon needs to be further elucidated.
Hubungan neutrophil-lymphocyte ratio, absolute lymphocyte count, dan platelet lymphocyte ratio terhadap derajat keparahan COVID-19
Authors: Nasrani Lusia 
Published: December 2022

Introduction: The COVID-19 virus was discovered at the end of 2019 as respiratory infectious disease and has become a pandemic until now, so it is very important to predict the severity of COVID-19. Neutrophil Lymphocyte Ratio (NLR), Absolute Lymphocyte Count (ALC), and Platelet Lymphocyte Ratio (PLR) are easy, inexpensive, and fast methods as screening tools for the severity of COVID-19. The purpose of this study was to determine the relationship between NLR, ALC, and PLR to the severity of COVID-19.Methods: This study is an analytic observational study with a cross-sectional research design—retrieving research data using the total sampling method. The research data are medical records and laboratory examination data from 64 COVID-19 patients at Harapan Keluarga Hospital Cikarang in July–December 2020. The data analysis used was bivariate analysis with chi-square.Results: There were 64 samples in this study, with the majority of samples being male, the average age was 42 years, the most common symptoms were fever (81.3%) and cough (71.9%), the majority of patients had no comorbidities. There was a significant relationship between NLR, ALC and PLR with the severity of COVID-19 (p = 0.007; p = 0.002; p = 0.013). Latar belakang: Virus COVID-19 ditemukan pada akhir tahun 2019 sebagai penyakit infeksi pada pernapasan dan telah menjadi pandemi hingga saat ini, sehingga sangat penting untuk memprediksi derajat keparahan COVID-19. Neutrophyl Lymphocyte Ratio (NLR), Absolute Lymphocyte Count (ALC), dan Platelet Lymphocyte Ratio (PLR) merupakan metode yang mudah, murah, dan cepat sebagai alat skrining pada keparahan COVID-19. Tujuan penelitian ini adalah untuk mengetahui hubungan NLR, ALC, dan PLR terhadap derajat keparahan COVID-19.Metode: Penelitian ini adalah suatu penelitian observasional analitik dengan desain penelitian crosssectional. Pengambilan data penelitian menggunakan metode total sampling. Data penelitian adalah data rekam medis dan pemeriksaan laboratorium dari 64 pasien COVID-19 di RS Harapan Keluarga Cikarang pada periode Juli–Desember 2020. Analisis data yang digunakan adalah analisis bivariat dengan chi-square.Hasil: Terdapat 64 sampel pada penelitian ini dengan mayoritas sampel merupakan laki-laki, rata-rata usia 42 tahun, gejala yang paling sering ditemukan adalah demam (81,3%) dan batuk (71,9%), mayoritas pasien tidak memiliki komorbid. Terdapat hubungan yang signifikan antara NLR, ALC dan PLR dengan tingkat keparahan COVID-19 (p =0,007; p=0,002; p =0,013).Simpulan: NLR, ALC, dan PLR memiliki hubungan terhadap derajat keparahan COVID-19.
Melanoma maligna orbita: sebuah laporan kasus
Authors: Sukmawati Ni Luh Putu Nurindah , Putu Yuliawati  , Ni Made Laksmi Utari  
Published: December 2022

Introduction: Orbital melanoma (OM) is the most common type of primary intraocular neoplasm in adults. Although the incidence of OM is only 5% of melanoma tumors, OM causes death in 13% of melanoma tumors. The management of orbital melanoma originating from the uveal tissue is still controversial between surgical and nonsurgical therapy.
Case Report: A male patient, 63 years old, complained that the patient's right eye was said to have appeared a lump since five months ago with a size of 6 x 6 x 7 cm, blackish red in color with clinical signs of malignancy. The patient underwent orbital exenteration and the patient's condition had no recurrence or other complaints until four months after the procedure.
Conclusion: Orbital melanoma of uveal origin is a complex malignancy that requires a multidisciplinary approach to therapy and management. Early detection and adequate therapy are very important in increasing survival rates.

Pendahuluan: Melanoma orbita (MO) merupakan tipe yang paling sering dari neoplasma primer intraokular pada dewasa. Meskipun insiden MO hanya 5% dari tumor melanoma, namun MO menimbulkan kematian pada 13% akibat tumor melanoma. Tatalaksana melanoma orbita yang berasal dari jaringan uvea sampai saat ini masih kontroversial antara terapi bedah dan nonbedah. Laporan Kasus: Seorang pasien laki-laki, 63 tahun, mengeluh mata kanan pasien dikatakan muncul benjolan sejak lima bulan yang lalu dengan ukuran 6 x 6 x 7 cm, berwarna merah kehitaman dengan klinis mengarah keganasan. Pasien dilakukan eksenterasi orbita dan kondisi pasien tidak terdapat kekambuhan ataupun keluhan lain hingga empat bulan setelah tindakan.
Simpulan: Melanoma orbita yang berasal dari uvea merupakan keganasan yang kompleks yang membutuhkan pendekatan multidisiplin dalam terapi dan tatalaksana. Deteksi dini dan terapi yang adekuat sangat penting dalam upaya meningkatkan angka ketahanan hidup.
Analisis kinerja pegawai bagian administrasi RSUP Ratatotok buyat di era sebelum pandemi COVID-19, saat pandemic, dan new normal
Authors: Manitik Riliani , Rampengan Starry Homenta , Wagey Freddy W. , Manampiring Aaltje Ellen 
Published: December 2022

Introduction: The success of hospitals (RS) in carrying out their functions as health service institutions is characterized by good quality hospital services. Administrative employees as non-health workers must have good performance in order to realize quality health services. This study aimed to analyze the description of employee performance in the administration section of the Ratatotok Buyat Hospital in terms of aspects of work culture and work environment in the era before the Covid-19 pandemic, during the pandemic and the new normal era.Methods: This type of research uses a qualitative descriptive method. Data collection techniques were carried out by in-depth interviews and then documented and analyzed. To obtain the validity of the data, inspection techniques were carried out through several activities, namely triangulation. Qualitative data was obtained based on the results of in-depth interviews using the Mile and Huberman data analysis modelResults: The performance of employees in the administration section shows that systems and activities related to employee work experience changes during the pandemic when there is a decrease in employee performance when compared to performance before the pandemic, in the new normal era, employee performance has increased.Conclusion: The performance of employees in the administration of Ratatotok Buyat Hospital before the Covid-19 pandemic was very good, there was a decline in performance during the pandemic, but increased again in the new normal era. Pendahuluan: Keberhasilan rumah sakit (RS) dalam menjalankan fungsinya sebagai lembaga pelayanan kesehatan ditandai dengan kualitas pelayanan rumah sakit yang baik. Pegawai administrasi sebagai tenaga non kesehatan harus memiliki kinerja yang baik agar dapat mewujudkan pelayanan kesehatan yang berkualitas. Penelitian ini bertujuan untuk menganalisis gambaran kinerja pegawai pada bagian administrasi Rumah Sakit Umum Pusat (RSUP) Ratatotok Buyat ditinjau dari aspek budaya kerja dan lingkungan kerja pada era sebelum pandemi Covid-19, saat pandemi dan era new normal.Metode: Jenis penelitian ini menggunakan metode deskriptif kualitatif. Teknik pengumpulan data dilakukan dengan wawancara mendalam kemudian didokumentasikan dan dianalisis. Untuk mendapatkan keabsahan data, dilakukan teknik pemeriksaan yaitu dengan triangulasi. Data kualitatif diperoleh berdasarkan hasil wawancara mendalam dengan menggunakan model analisis data Mile dan Huberman.Hasil: Kinerja pegawai dibagian administrasi menunjukkan bahwa saat pandemi terjadi penurunan jika dibandingkan dengan dengan kinerja sebelum pandemi, diera new normal kinerja pegawai kembali mengalami peningkatan.Kesimpulan: Kinerja pegawai di bagian administrasi RSUP Ratatotok Buyat sebelum pandemi Covid-19 sangat baik, dan terjadi penurunan kinerja saat pandemi, namun kembali mengalami peningkatan di era new normal.
Relationship between Monocarboxylate Transporter 4 (MCT-4) Expression and Breast Cancer Clinicopathology and Subtype in Sanglah General Hospital, Denpasar, Indonesia
Authors: Nicolas Gede Andry Nicolas Andry , Sudarsa I Wayan , Adiputra Putu Anda Tusta , Wihandani Desak Made , Supadmanaba I Gede Putu 
Published: December 2022

Background: Breast cancer is the second leading cause of death in women in developing countries. The activity of Warburg and Reverse-Warburg effects on breast cancer is reflected by the expression patterns of two molecules, namely caveolin-1 and Monocarboxylate Transporter-4 (MCT-4). MCT-4 is a transmembrane transport protein that transports lactate from the cytoplasm to the intercellular fluid.Method: This is a cross-sectional analytical study to determine the relationship between MCT-4 expression and breast cancer clinicopathology and subtypes. The study was conducted between April and May of 2020 with 62 breast cancer patients as samples in Sanglah General Hospital, Denpasar. Analysis was done with SPSS 25.Results: A logistic regression analysis was performed to analyze the relationship between the dependent variable (MCT-4) and the covariates (stage, grade, and subtype). Of the three variables significantly associated with MCT-4 expression, only clinical-stage and subtype (luminal and non-luminal) remained independently associated with MCT-4 expression. Analysis on the clinical stage and subtype variables showed an adjusted OR of 4.727 (p = 0.047; 95% CI: 1.109 - 21.922) and 17.850 (p = 0.009; 95% CI: 2.069 - 154.003) , respectively. This suggests that MCT-4 has a significant association with subtype and clinical-stage, increasing the risk of cancer stage progression and developing a more malignant (non-luminal) subtype.Conclusion: High MCT-4 expression was significantly associated with malignant subtypes, high histological-grade cancer and advanced breast cancer.