bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-alcoholic fatty liver disease may be a risk factor for liver metastasis after radical surgery for colorectal cancer: a retrospective study
Authors: Miyata Takashi , Shinden Yuki , Motoyama Shota , Sannomiya Yuta , Tamezawa Hozumi , Nagayama Taigo , Kin Ryosuke , Nishiki Hisashi , Hashimoto Akifumi , Kaida Daisuke , Tomita Yasuto , Nakamura Naohiko , Miyashita Tomoharu , Fujita Hideto , Ueda Nobuhiko , Takamura Hiroyuki 
Published: October 2022

Abstract

Background
The liver is the most common site for distant colorectal cancer (CRC) metastasis, which develops in approximately one-third of CRC patients who undergo radical surgery. Hepatectomy for colorectal liver metastasis (CRLM) is the only potentially curative treatment for these patients. However, few metastatic CRC patients meet the criteria for this radical resection, and they have a low 5-year survival rate. Among those who undergo hepatectomy for CRLM, the recurrence rate is 60%. Thus, identifying risk factors for patients with CRLM is critical. One risk factor is non-alcoholic fatty liver disease (NAFLD), the incidence of which is increasing worldwide. NAFLD has become a main cause of chronic liver disease, and it is also an independent risk factor for CRC development. However, the effect of NAFLD on CRC liver metastasis after radical surgery remains unclear. The aim of this study was to retrospectively investigate the impact of NAFLD-associated hepatic fibrosis on liver metastasis after radical surgery for CRC.
Methods
We retrospectively analyzed data from 388 CRC patients with hepatic metastasis who underwent curative hepatectomy for CLRM at our hospital between April 2008 and March 2015. Data on each patient’s clinical results, surgical procedure, and postoperative course and their pathological and survival data were collected from our hospital records. The NAFLD fibrosis score (NFS) was also calculated, and patients were divided into two groups (NAFLD and non-NAFLD) on the basis of the NFS.
Results
Recurrence was observed in 83 (21.4%) of 388 patients after a mean follow-up 65.6 ± 15.1 months. Twenty-five patients had liver metastasis, and eight of them had NAFLD (8/45; 17.8%), while 17 of them (17/343; 5.0%) did not have NAFLD (p = 0.004). Additionally, liver metastasis-free survival in NAFLD patients was significantly worse than that in non-NAFLD patients (p < 0.001). We also showed that NAFLD and stage were independent risk factors for liver metastasis recurrence.
Conclusions
These results suggest that NAFLD may be a risk factor for liver metastasis in CRC patients who undergo curative surgery.
Optimal investment-consumption and life insurance strategy with mispricing and model ambiguity
Authors: Gu Ailing , He Xinya , Chen Shumin , Yao Haixiang 
Published: October 2022

Abstract
In this paper, we consider the optimal investment-consumption and life insurance strategy for a wage earner, who has uncertain labour income described by an Ornstein-Uhlenbeck process. In addition to consumption and purchasing life insurance, the wage earner invests his wealth into the financial market, which consists of a risk-free asset, a market index and a pair of risky assets with mispricing. Our aim is to maximize the expected utilities obtained from consumption, bequest, or his wealth at the end of decision horizon.With dynamic programming approach, we obtain explicit solutions for the optimization problem by solving the corresponding HJB equation. Finally, several numerical examples are presented to illustrate our results.
Improving the antioxidant defense system in different species of Citrus fruits under cold stress using osmolytes
Authors: Mohammadrezakhani Soheila , rezanejad farkhondeh 
Published: October 2022

Abstract
Background
Citrus fruits are one of the most important horticultural fruits in the world. Cold stress, as one of the most important environmental stresses, prevents the physiological processes of plants and causes a decrease in yield and even their death. In this research, the interaction of putrescine with proline and temperatures of 1, -1, and − 3°C have been done in order to investigate the changes of antioxidant systems in fruits of three Citrus speices.
Results
The results of comparison of means showed that antioxidant capacity incresed with decreasing of temperature. In addition, application of putrescine and proline with different concentrations was led to an improvement in the amount of antioxidant capacity compared to control fruits.
Conclusions
The comparison between Citrus species showed that the highest levels of antioxidant capacity in treated and untreated fruits were observed in C. reticulata while the lowest levels were seen in C. paradisi indicating that C. reticulata has a higher resistance than the other species.
Mining of clinical and prognosis related genes in the tumor microenvironment of endometrial cancer
Authors: Li Wenxue , Qin Yujing , Chen Xiujuan , Wang Xiaolei 
Published: October 2022

Abstract
Background: Endometrial cancer (EC) is the sixth most common malignant tumor in women worldwide, and its morbidity and mortality are on the rise.The purpose of this study was to explore potential tumor microenvironment (TME) related biomarkers associated with clinical features and prognosis of EC.
Methods: Estimating Stromal and Immune Cells in Malignancy Using Expression Data (ESTIMATE) algorithm was used to calculate TME immune score and stromal score of EC samples obtained from The Cancer Genome Atla (TCGA), and analyze the relationship between immune/stromal scores and clinical features and prognosis. Heat map and Venn map were drawn to screen differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed for differentially expressed intersection genes and Protein–protein interaction (PPI) network was constructed. Kaplan-meier survival analysis and multivariate Cox analysis were used to screen the clinical and prognostic related genes of EC.
Results: The immune score was significantly correlated with the overall survival and tumor grade of EC. A total of 1448 DEGs were screened according to immune/stromal scores, of which 387 genes were intersection genes. GO analysis found that the biological processes related to intersection genes mainly included T cell activation and regulation of lymphocyte activation. KEGG analysis showed that intersection genes were closely related to immune-related signaling pathways, especially T cell immunity.30 core genes with more than 7 nodes were identified by PPI. 6 independent prognostic genes of EC were found, namely, CD5, BATF, CACNA2D2, LTA, CD52, and NOL4,which were all immune infiltrating genes and closely related to clinical features.
Conclusion:The current study identified 6 key genes closely related to immune infiltration in TME of EC that predict clinical outcome, which may provide new insights into novel prognostic biomarkers and immunotherapy for EC patients.
Embedded 3D printing of Multi-material composites
Authors: Zhou Shitong , Tirichenko Iuliia S , Zhang Xun , Hong Yinglun , Payne Harry , Withers Philip , Bouville Florian , Saiz Eduardo 
Published: October 2022

Abstract

Additive manufacturing could open new opportunities in the design and fabrication of advanced composites and devices incorporating multiple phases. However, when it comes to the combination of inorganic materials (ceramics and metals) it is difficult to achieve the degree of structural control demanded by many advanced applications. To address this challenge, we have developed a means of embedded printing to build complex, fine structures within dense ceramics. We have formulated a self-healing ceramic gel that enables the movement of a printing nozzle in its interior and that heals without defect after it has passed. Upon subsequent heat treatment, the gel forms a dense, defect-free ceramic that encapsulates the printed structure. We demonstrate the potential of the technique through two case studies. One is the printing of light, sacrificial graphite structures to introduce complex microchannel arrangements in a ceramic for applications such a thermal management. The other is to embed dense steel framework structures in aluminum oxide to increase its fracture resistance. The approach enables the introduction of auxetic structures that generate works of fracture 50% greater than those obtained with simple fibre arrays and that are orders of magnitude above the fracture energy of the ceramic. These results suggest that embedded 3D printing can open the way to implement new designs in ceramic matrix composites.
Optimized Isolation and Characterization of Cellulose for Extraction of Cellulose Nanocrystals from Ensete Ventricosum Pseudo-Stem Fiber Using Two-Stage Extraction Method
Authors: Dube Abnet Mengesha , Daba Bulcha Jifara , Muleta Melkiyas Diriba 
Published: October 2022

Abstract
Alkali treatment followed by alkalinized hydrogen peroxide delignification yielded 73.90% cellulose from Ensete Ventricosum pseudo stem fiber, with parameters optimized using response surface methodology. The optimal reaction parameters were 157 minutes, 73 ℃, and 3.8% NaOH concentration. Thermogravimetric analysis (TGA), X-ray diffraction (XRD), Fourier transfer infrared (FTIR), and scanning electron microscopy were used to examine the thermal properties, crystal structure, chemical structure, and morphological structure of isolated cellulose (SEM). Based on the findings, cellulose has a rod-like shape. The XRD results revealed that the crystallinity index of cellulose increased from 65 to 75 percent when compared with raw Enseteventricosum pseudo stem fiber (Ensete fiber). The resultant cellulose demonstrated relatively higher thermal stability than the unprocessed ensete fiber, according to the thermogravimetric examination. When compared to raw ensete fiber, FTIR analysis revealed that cellulose had a modified chemical functional structure, which suggested that alkali and alkalized hydrogen peroxide treatments had altered the chemical structure of cellulose. According to the results, it is possible to extract cellulose nanocrystals thanks to the isolated cellulose's high yield, great crystallinity index, strong thermal stability, and morphological structure.
Superior Gait Performance and Postural Stability among Yoga Instructors – Inertial Measurement Unit-Based Evaluation
Authors: Lin Ang-Chieh , Lin Tzu-Tung , Tan Yin-Keat , Pan Wei-Ren , Shih Chih-Jen , Lee Chun-Ju , Chen Szu-Fu , Wang Fu-Cheng 
Published: October 2022

Abstract
Background

Yoga movements involve a series of motions of the core and lower limb muscles that require constant body adjustments to maintain balance and proper body alignment. Inertial measurement unit, a wearable device that is consisted of 3-axis accelerometers, 3-axis gyroscopes and 3-axis magnetometers, can provide objective data for motion analysis. This study aimed to investigate gait symmetry and single-leg stance balance of professional yoga instructors versus age-matched normal controls using inertial measurement unit (IMU) - based evaluation.

Methods

Twenty-five yoga instructors and twenty-five healthy control subjects were recruited to conduct the walking experiments and single-leg stance tests. Kinematic data were measured by attaching IMUs to the lower limbs and trunk. The asymmetry of swing phases during gait cycles was assessed using the normal walk and tandem walk tests with eyes open and closed, respectively. The subjects subsequently conducted four single-leg stance tests, including a single-leg stance on both legs with eyes open and closed. Two balance indexes regarding the angular velocities of the waist and chest were defined to assess postural stability.

Results

The gait asymmetry indexes of yoga instructors were significantly lower than those of the normal controls on normal walk and open-eye tandem walk tests. The asymmetry indexes also showed a smaller value in the yoga instructors on close-eye tandem gait; however, it did not reach statistical significance. Similarly, the yoga instructors had better body balance, that is, smaller angular velocities on both the waist and chest, in all four single-leg stance tests. This indicates superior postural stability over both the waist and chest levels of yoga instructors during the single-leg stance.

Conclusion

The findings of this study suggest that yoga practice improves gait asymmetry and balance ability in healthy adults. However, further intervention studies are needed to confirm the effect of yoga training.
Trial Registration: This study was registered with an ClinicalTrials.gov Identifier: NCT05449730.
Identification of Biomarkers Related to Tumor Associated Macrophages in Clear Cell Renal Cell Carcinoma with Weighted gene co-expression network analysis
Authors: Jiang Yunzhong , Zhang Mengzhao , Zhang Lu , Wang Lu , Ma Minghai , Jing Minxuan , Li Jianpeng , Song Rundong , Zhang Yuanquan , Yang Zezhong , Zhang Yaodong , Pu Yuanchun , Fan Jinhai 
Published: October 2022

Abstract
Background
Tumor associated macrophages (TAMs) play an exceedingly important role in tumor microenviroment (TME). However, few studies has reported the specific biomakers and TAM related gene signature in clear cell renal carcinoma (RCC). Herein, our research aims to pick out specific biomakers and construct a TAM related gene prognostic signature in clear cell renal carcinoma.
Methods
We downloaded clear cell renal carcinoma patients sequence data from The Cancer Genome Atlas (TCGA). Then, we used CIBERSORT and QuanTIseq algorithm to estimate the percentage of immune cell infiltration. Weighted gene co-expression net work analysis (WGCNA) could sort the specific genes related to TAM(M2 macrophage) in clear cell renal carcinoma. In addition, Least Absolute Shrinkage and Selection Operator (LASSO), univariate and multivariate Cox regression were performed to establish a TAM related gene prognostic model in clear cell renal carcinoma patients. At last, single cell sequence from Gene Expression Omnibus (GEO) was also verify the expression of TAM realated genes.
Results
We found that TAM (M2 macrophage) infiltration was higher than normal tissue, which suggested that TAM may play an vital role in clear cell renal carcinoma progression. Twenty-seven TAM related genes was picked out by using WGCNA. In addition, the six gene prognostic signature which contained: TNFSF8, CD300FL, C3AR1, LAIR1, LY86, RNASE6 was established. We concluded that the riskscore and tumor stage were independent prognostic factors through univariate and multivariate Cox regression analysis. Single cell sequence results show that the six hub genes were all expressed in TAMs.
Conclusions
In summary, our research discovered that the TAM related genes and constructed a six gene prognostic signature for clear cell renal carcinoma, which may provide a novel insight for targeting therapy in clear cell renal carcinoma.
Dirofilarial Nodule as a Differential Diagnosis for Subcutaneous Lumps in Children
Authors: Wijekoon Naveen , Antony Diroji , Muhunthan Tharushihan , Samarasinghe Malik 
Published: October 2022

Abstract
Purpose
Subcutaneous nodules in children are commonly caused by pilomatrixoma, dermoid cysts, soft tissue tumors etc. Parasitic infections are reported to cause subcutaneous nodules and are infrequently described, mostly in the adult literature. We aim to describe the clinicopathological features of subcutaneous lumps caused by dirofilarial infestation in children in an endemic country.
Methods
A retrospective analysis was performed of all patients presenting with the above condition to Lady Ridgeway Hospital from 2018 to 2022 and their relevant details were captured in a proforma.
Results
There were 55 patients with a male to female ratio of 2:1. The mean age at presentation was 50 months (7–156 months). The mean duration was 97 days (1-820 days). The common sites involved were scrotum (30.9%), back (14.5%), abdominal wall (102.7%) and face (10.9%). The majority had a painless nodule (70.9%) while 10 (18.2%) had features of acute inflammation. Thirty (55.5%) had preoperative ultrasonography which showed features of parasitic nodules in 26 (47.3%). Parasite was demonstrated in histopathological analysis only in 30 patients (54.5%).
Conclusion
Dirofilarial nodule should be considered in the differential diagnosis of subcutaneous lumps in children, especially in the endemic areas.
Evaluation of symptomatic small bowel stricture in Crohn’s disease by double-balloon endoscopy
Authors: Hu Jing , Wu Juan , Zhang Peipei , Hu Naizhong , Mei Qiao , Wu Xingwang , Han Wei 
Published: October 2022

Abstract

Purpose: To assess the efficacy of double-balloon endoscopy (DBE) for the detection of small-bowel stricture in Crohn’s disease (CD).
Methods: This Tertiary-referral hospital cohort study was conducted between January 2018 and May 2022. CD patients with symptoms of small-bowel stricture were enrolled sequentially. All of the patients were subjected to both computed tomography enterography (CTE) and DBE, and their symptoms of stricture were assessed using the Crohn’s Disease Obstructive Score (CDOS). DBE diagnostic yield was compared to CTE, and the relationship between DBE findings and CDOS was investigated. The factors influencing DBE diagnosis were examined using Cox regression analysis.
Results: This study included 165 CD patients. CDOS scores were higher in 95 patients, while lower in 70. DBE detected 92.7% (153/165) and CTE detected 85.5% (141/165) of the strictures, respectively. DBE diagnostic yields were 94.7% (90/95) in high CDOS patients and 91.4% (64/70) in low CDOS patients (P = 0.13). Patients with a history of abdominal surgery and abscess had a lower diagnosis rate in the multivariate analysis.
Conclusion: DBE has been demonstrated to be an efficient diagnostic method for detecting small-bowel strictures in CD patients. Additionally, there is no difference in diagnostic yields between patients with low and high obstructive scores.
Atom Search Optimization based Load Frequency Control and Firefly Algorithm based cost optimization for an interconnected power system with Renewable Energy Sources
Authors: K Ranjitha , P Sivakumar , A Rajapandiyan 
Published: October 2022

Abstract
To minimize the frequency deviation in a power system containing Renewable Energy Sources, high efficient and robust controllers need to be designed. Maintaining the system frequency and tie-line power in its nominal value is very important to maintain the stability of the power system. For this motive, a novel cascaded controller with Proportional Integral Derivative (PID) and Atom Search Optimized (ASO) PID controller is proposed for load frequency control of a multi-area multi-source power system containing both conventional and renewable generating sources. Further, one of the important Demand side management (DSM) measure, Time of demand (TOD) tariff based cost optimization is done for 62 bus Indian utility system with some renewable energy-based power generation by applying the Firefly algorithm (FA). The Novel ASO can outperform familiar methods and is more competitive with new approaches for parameter estimation and FA has high convergence speed, both these optimizations are faster than other available methods. For analyzing the performance of the controller various test cases are analyzed considering load and source variation. The supremacy of the result of the proposed methodology is demonstrated by comparing the result with classical PID and Fuzzy PID controller for the same system in terms of settling time, peak magnitude and TOD cost.
Different Oxidation Methods on the Wetting and Diffusion Characteristics of 304 Stainless Steel on High Alumina Glass
Authors: SUI Liwei , CHEN Changjun , ZHANG Min 
Published: October 2022

Abstract
This paper presents the influence of different pretreatment methods on the high-temperature wettability of 304 stainless steel and high alumina glass sealing process, including laser surface melting and pre-oxidized treatment. The bonding characteristics of the glass and stainless steel directly depend on the wettability in terms of measured wetting angle, types of oxide formed at the stainless steel surface and microstructural changes during the manufacture process. Comparing quality and thickness of oxide film on the surface of stainless steel to obtain better parameters, and then wetted with high alumina powder at different temperatures. The result shows that pre-oxidized treatment appears a decrease in wetting angle from 56.16° to 33.65°, with laser melted surface showing from 49.76° to 31.54°. XPS shows that surface and adjacent depth have higher concentration of FeO for laser treated stainless steel than that pre-oxidized treated one. SEM reveals that oxide film on the surface is thicker and harder than the pre-oxidized one. This attributes to the oxygen and iron elements can move inward and outward better to form the interface reaction layer. The work shows laser surface melting has a better influence on the wetting and diffusion characteristics of 304 stainless steel onto high alumina glass.
Long-term oncologic outcomes of intersphincteric resection versus abdominoperineal resection for low rectal cancer without preoperative therapy
Authors: Huang Taotao , Hu Mengmu , Lu Xiancheng , Lu Yingjie , Wang Yiran , Pan Yifei , Ni Shicang , Song Huayu , Chang Xu , Ye Lechi , Xiang Youqun , Zuo Zhigui 
Published: October 2022

Abstract
Purpose
This study analyzed the oncologic outcomes of patients with low rectal cancer undergoing intersphincteric resection (ISR) compared with those underwent APR to evaluate the oncologic safety of ISR.
Methods
This study enrolled 149 patients undergoing ISR and 166 patients receiving APR for LRC from January 2010 to December 2020. The exclusion criterion included neoadjuvant therapy or other malignant tumors. Moreover, this study used propensity score matching to reduce possible confounding factors.
Results
After comparing 123 patients from each group, comparable long-run outcomes were observed in both groups. ISR and APR groups showed 5-year disease-free survival rates of 69.8% and 57.2% (p = 0.146), 5-year overall survival rates of 82.8% and 74.4% (p = 0.164), and 5-year local recurrence-free survival rates of 81.8% and 72.0% (p = 0.109), respectively. For paired patients receiving laparoscopic surgery, close outcomes were observed. Moreover, ISR showed comparable oncologic safety for locally advanced cancer to APR.
Conclusions
In this study, ISR and APR showed close oncological results regardless of the surgery approach for patients with LRC without neoadjuvant chemoradiotherapy(nCRT). In addition, this study suggested that ISR may be safe for locally advanced cancer if circumferential resection margins could be ensured negative.