bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of high frequency-repetitive transcranial magnetic stimulation on pattern visual evoked potential and vasoactive intestinal peptide expression in visual cortex of rats with amblyopia
Authors: Song Weiqi , Fan Haobo , zou Yunchun , Tang Xiuping , Wang Ying , Xie Juan 
Published: October 2022

Abstract
Aim
To explore the effects of high frequency-repetitive transcranial magnetic stimulation (hf-rTMS) on pattern visual evoked potential (PVEP) and vasoactive intestinal peptide (VIP) expression in visual cortex of rats with amblyopia and to preliminarily discuss the underlying mechanism of action.
Methods
Thirty SD rats aged 3 weeks were randomly selected and equally divided into the normal control group (NC), monocular deprivation group (MD), and monocular deprivation + hf-rTMS group (MD + hf-rTMS). Rats in the NC group were not intervened. Rats in the MD and MD + hf-rTMS groups were used to establish an amblyopia model by suturing the lid in the right eye for 3 weeks, while rats in the MD + hf-rTMS group were further intervened by two weeks of hf-rTMS. PVEP was tested in the right eye of rats at 6 and 8 weeks of age. Rats at 8 weeks of age were sacrificed, and the left visual cortex was extracted for immunohistochemistry (IHC) and in situ hybridization (ISH) examinations.
Results
At 6 weeks of age, there was no significant difference between the MD and MD + hf-rTMS group in terms of the P100 wave (P < 0.05). Besides, in comparison to the NC group, both the two groups had a distinct reduction in P100 amplitude (P < 0.05) and a prolonged latency (P < 0.05). At 8 weeks of age, the P100 amplitude in the MD + hf-rTMS group increased evidently than that in the MD group (P < 0.05). As compared to the NC group, the MD + hf-rTMS group had a remarkably lower P100 amplitude (P < 0.05). No distinct difference was found in the latency between the MD + hf-rTMS group and the MD or NC group (P > 0.05). IHC and ISH analyses demonstrated that VIP was expressed in all groups, and the mean OD value and the number of VIP-positive cells in the MD + hf-rTMS group were significantly higher than those in the MD group (P < 0.05) but distinctly lower than those in the NC group (P < 0.05).
Conclusion
hf-rTMS could increase the VIP expression in visual cortex and improve visual transduction in rats with amblyopia.The mechanism of hf-rTMS may be to participate in the remodeling of the visual system by improving the expression of VIP
WITHDRAWN: Investigating User Experience (UX) on the Top Most Frequently Visited E-Commerce Websites in Malaysia
Authors: Hasan Layla 
Published: October 2022

Abstract
This research developed specific criteria to evaluate user experience of e-commerce websites. These consist of 40 metrics: 27 metrics to evaluate utilitarian benefits (quality) and 13 metrics to evaluate hedonic benefits (quality) of any e-commerce website. Then, the research investigated the user experience (UX) on the top three most frequently visited e-commerce websites in Malaysia (Shopee, Lazada, Pgmall) in two stages using questionnaires and semi-structured interviews based on the developed criteria. The results identified both common and unique major issues and strong features (utilitarian and hedonic), as well as common and unique minor issues and strong characteristics (utilitarian and hedonic) on the tested e-commerce websites, which affected users’ experience on the sites. The results also showed that the quality of the utilitarian features of the e-commerce websites affected the quality of the hedonic features of the sites. Poor quality utilitarian features on e-commerce websites from the point view of participants resulted in identifying negative (low quality) hedonic features on those sites. The results also proved the usefulness and effectiveness of employing semi-structured interviews to obtain rich information regarding the user experience. Based on the results of this research, recommendations were suggested to achieve positive experiences on e-commerce websites from the point view of users.
Aberration measurements by Talbot wavefront sensor in presence of intensity variations
Authors: Kotov Myhailo , Danko Volodymyr , Goloborodko Andrii 
Published: October 2022

Abstract
Paper deals with the theoretical investigations of measurement accuracy of optical aberrations by Talbot wavefront sensor in the presence of random amplitude variations. Theoretical prediction of intensity distribution for gratings of any type based on their spatial spectrum is obtained, and it is shown that grating is fully restored in Talbot plane even for the high fraction of random amplitude. The possibilities of self-imaging phenomenon is investigated based on the simulation results. Simulation results show that pit displacement error increases when the correlation length decreases or when grating spatial spectrum increases. It is found that for defocus aberration intensity variations decrease measured defocus value and increment of aberrations of same order (oblique and vertical astigmatisms).
PACS 42.25.Fx · 42.25.-p · 42.15.Dp
Leveraging an open source serverless framework for High Energy Physics computing
Authors: Padulano Vincenzo Eduardo , Cortés Pablo Oliver , Alonso-Jordá Pedro , Saavedra Enric Tejedor , Risco Sebastián , Moltó Germán 
Published: October 2022

Abstract
CERN (Centre Europeen pour la Recherce Nucleaire) is the largest research centre for High Energy Physics (HEP). It offers unique computational challenges as a result of the large amount of data generated by the Large Hadron Collider (LHC). CERN has developed and supports a software called ROOT, which is the de facto standard for HEP data analysis. This framework offers a high-level and easy-to-use interface called RDataFrame, which allows managing and processing large data sets. In recent years, its functionality has been extended to take advantage of distributed computing capabilities. Thanks to its declarative programming model, the user-facing API can be decoupled from the actual execution backend. This decoupling allows physical analysis to scale automatically to thousands of computational cores over various types of distributed resources. In fact, the distributed RDataFrame module already supports the use of established general industry engines such as Apache Spark or Dask. Notwithstanding the foregoing, these current solutions will not be sufficient to meet future requirements in terms of the amount of data that the new projected accelerators will generate. It is of interest, for this reason, to investigate a different approach, the one offered by serverless computing. Based on a first prototype using AWS Lambda, this work presents the creation of a new backend for RDataFrame distributed over the OSCAR tool, an open source framework that supports serverless computing. The implementation introduces new ways, relative to the AWS Lambda-based prototype, to synchronize the work of functions.
Stability and minimal decay rate of systems of ODE
Authors: Kushel Olga , Pavani Raffaella 
Published: October 2022

Abstract
In this paper, we provide new stability conditions for second-order dynamical systems. We study the stability conditions for a parameter-dependent second order model and the minimal decay rate for some variations of positive parameters. A certain way of gyroscopic stabilization of an unstable parameter-dependent system is also considered.
Mathematics Subject Classification (2010) 15A18 · 15A12 · 34D10
Programmable control over the coffee-ring formation through the use of the multi-ring mechanism guided by the self-assembly of magnetic nanoparticles
Authors: Marc Maciej , Wolak Wiktor , Drzewinski Andrzej , Dudek Miroslaw Roman 
Published: October 2022

Abstract
The control of the mechanism leading to the appearance of the ring-shaped stains from the dried liquid colloidal droplets has been the subject of intense studies over the last 25 years. This stems from the immense significance of this effect for technological applications. One of the key open topics in this field is the emergence of a regular multi-ring deposit from the dried droplet. Here, we show that magnetic nanoparticles in a drying magnetic liquid droplet can self-assemble into a multi-ring deposit structure, and even more importantly, a magnetic field can be turned on to control the underlying processes. The magnetic liquid is prepared as an aqueous suspension of Fe3O4 magnetic nanoparticles stabilized with (3-Aminopropyl)triethoxysilane (APTES) and its droplets are placed on low-density polyethylene (LDPE) film. The results of this work are expected to be very promising in the case of multiple applications including ink-jet printing methods and 2D printed electronics.
C-section delivery induces gut barrier-microbiota imbalances in early life and leads to higher sensitivity to inflammation
Authors: Barone M , Ramayo-Caldas Y , Estellé J , Tambosco K , Chadi S , Maillard F , Gallopin M , Planchais J , Chain F , Kropp C , Rios-Covian D , Sokol H , Brigidi P , Langella P , Martín R 
Published: October 2022

Abstract
Background
The mother-newborn transmission of microorganisms is the most important factor influencing microbial colonization in the neonate, and C-section delivery (CSD) is an important disruptive factor of this transfer. Although this medical procedure saves countless lives, it may also have costs. Recently, the deregulation of symbiotic host-microbe interactions in early life has been shown to alter the maturation of the immune system, predisposing the host to gut barrier dysfunction and inflammation. The main goal of this study is to decipher the role of CSD in the early-life gut microbiota-barrier alterations and its links with later-life risks of intestinal inflammation.
Results
The higher sensitivity to inflammation in CSD mice is related to excessive exposure to a too diverse microbiota too early in life. This early microbial stimulus has short-term consequences on the host homeostasis. It switches the newborn immune response to an inflammatory context and alters the epithelium structure and the mucus-producing cells, disrupting gut homeostasis. This "too much too early" principle involves a disproportionate short-chain fatty acids ratio and an excessive antigen exposure across the vulnerable gut barrier in the first days of life. Besides, as shown by microbiota transfer experiments, the microbiota is causal in the high sensitivity of CSD mice to chemical-induced colitis and in most of the phenotypical parameters found altered in early life. Finally, supplementation with Lactobacilli, the main bacterial group impacted by CSD in mice, reverts the higher sensitivity to inflammation in ex germ-free mice colonised by CSD pups’ microbiota.
Conclusions
Early life gut microbiota-host crosstalk alterations related to CSD could be the linchpin behind the phenotypic effects that lead to increased disease susceptibility later in life.
London Underground air pollution particles are finer than you think
Authors: Sheikh Hassan Aftab , Tung Po-Yen , Ringe Emilie , Harrison Richard J 
Published: October 2022

AbstractParticulate matter (PM) concentration levels in the London Underground (LU) are higher than London background levels, and beyond World Health Organization defined limits. Wheel, track, and brake abrasion are the primary sources of particulate matter, producing predominantly Fe-rich particles that make the LU microenvironment particularly well suited to study using environmental magnetism. Here we combine magnetic properties, high-resolution electron microscopy, and electron tomography to characterize the structure, chemistry, and morphometric properties of LU particles in three dimensions with nanoscale resolution. Our findings show that LU PM is dominated by 5-500 nm particles of oxidized magnetite, occurring as 0.1-2 µm aggregated clusters, skewing the size-fractioned concentration of PM artificially to larger sizes when measured with traditional monitors. Magnetic properties are largely independent of the PM filter size (PM10, PM4, and PM2.5), and demonstrate the presence of superparamagnetic, single-domain, and vortex/pseudo-single domain signals only (i.e., no multi-domain particles > 1 µm). The oxidized state of the particles suggests that PM exposure in the LU is dominated by resuspension of aged dust particles relative to freshly abraded, metallic particles from the wheel/track/brake system, suggesting that periodic removal of accumulated dust from underground tunnels might provide a cost-effective strategy for reducing exposure. The abundance of ultrafine particles identified here could have particularly adverse health impacts as their smaller size makes it possible to pass from lungs to the blood stream. Magnetic methods are shown to provide an accurate assessment of ultrafine PM characteristics, providing a robust route to monitoring, and potentially mitigating this hazard.
Evaluation of the Reliability, Utility, and Quality of the Lid Loading Videos on YouTube
Authors: Balci Ali Safa , Cabuk Kubra Şerefoglu , Topcu Husna , Efe Ayse Cetin , Ulas Mehmet Goksel 
Published: October 2022

Abstract
Purpose:
It is aimed to determine the utility, reliability and quality of the lid loading videos on YouTube, a video sharing platform.
Methods:
A YouTube searches were made with the keywords 'Eyelid Loading', 'Gold Weight Implantation', 'Lid Loading for Lagophthalmos' (without user login, cleared search history, in incognito tab). A total of 75 videos were recorded. Length of videos (seconds), number of views, uploaded source (doctor/health institution/medical channel), number of subscribers, number of likes, time since uploading (days), video content (surgical/theoretical information), type of narration (verbal narration/subtitle) recorded. DISCERN, The Journal of the American Medical Association (JAMA), and Global Quality scores of the videos were evaluated and recorded by two experienced oculoplastic surgeons (KSC, HT).
Results:
After the exclusion criteria, the remaining 46 videos were included in the study. The mean DISCERN score was 25.17 ± 6.88 (very poor quality), the JAMA score was 0.79 0.63 (very poor quality), GQS was 2.84 ±1.03 (medium quality). Thirty videos (65.2%) had verbal narration and 16 videos (34.8%) had subtitled narration. The DISCERN score and GQS were significantly higher in the videos with verbal narration compared to the narration with subtitles (p<0.05). All 3 scores were positively correlated with each other. There was also a positive correlation between video length, number of subscribers, and DISCERN score.
Conclusions:
The videos about lid loading on YouTube are of poor reliability, accuracy, and educational quality. The duration of the video and the type of narration can be kept in the foreground when choosing the video. Experts must review the content that is uploaded to websites like YouTube.
Reliable Adaptive Distributed Hyper Parameter Optimization (RadHPO) for Deep Learning Training and Uncertainty Estimation
Authors: Li John , Pantoja Maria , Fernández-Escribano Gerardo 
Published: October 2022

Abstract
Training and validation of Neural Networks (NN) are very computation-ally intensive. In this paper, we propose a NN infrastructure that achieves two goals: to accelerate model training, specifically for hyperparameter optimization (HPO), and to re-use some of these intermediate models to evaluate the uncertainty of the model. By accelerating model training , we can obtain a large set of potential models and compare them in a shorter amount of time. Automating this process reduces development time and provides an easy way to compare different models. Our application runs different models on distinct servers with a single training data set, each with tweaked hyperparameters. By adding uncertainty to our results, our framework provides not just a single prediction but a distribution over prediction. Adding uncertainty is essential to some NN since most models assume that the input data distribution is identical between test and validation. However, in reality , they are not producing some dreadful mistakes. Since our solution is a distributed system, we make our implementation robust to common distributed system failures (servers going down, loss of communication among some nodes, and others). Furthermore, we use a gossip-style heartbeat protocol for failure detection and recovery. Finally, some preliminary results using a black-box approach to generate the training models show that our infrastructure scale well in different hardware platforms.
Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing Pannexin-1-mediated ferroptosis in db/db mice
Authors: Sun Jian , Xu Jiyu , Liu Yong , Lin Yitong , Wang Fengge , Han Yue , Zhang Shumin , Gao Xiaoyan , Xu Changqing , Yuan Hui 
Published: October 2022

Abstract
Diabetic cardiomyopathy (DCM) is a serious complication and death cause of diabetes mellitus (DM). Recent cardiology studies suggest that spermidine has cardioprotective effects. Here, the hypothesis was tested the spermidine effects of DCM. Therefore, db/db mice and primary neonatal mouse cardiomyocytes were used to observe the effects of spermidine. Immunoblotting showed that ornithine decarboxylase (ODC) and SPD/spermine N1-acetyltransferase (SSAT) were downregulated and upregulated in the myocardium of db/db mice, respectively. We found that diabetic mice showed cardiac dysfunction in 12 weeks. Conversely, exogenous spermidine could improve cardiac functions and reduce the deposition of collagens, myocardial damage, ROS levels and endoplasmic reticulum stress in diabetic mouse hearts. Our results also demonstrated that cardiomyocytes appeared ferroptosis and then activated Pannexin-1 expression, which resulted in increasing the extracellular ATP. Subsequently, increased ATP as a paracrine molecule combined to P2X7 receptors to activate ERK1/2 signaling pathway in cardiomyocytes, and activated NCOA4-mediated ferroptinophagy to promote lipid peroxidation and ferroptosis. Interestingly, spermidine could reverse these molecular processes. Our findings indicate an important new mechanism for DCM, and suggest spermidine have potential applicability to protect against deterioration of cardiac function with DCM.
Feasibility and Safety of Subcutaneous Sternal Suspension in The Treatment of Pectus Excavatum
Authors: Jing Tao , Jiang Peng , Feng Haiming , Zhang Shaobo , Wei Xiaoping , Song Tieniu , Yan Weijian , Lin Junping , Wang Cheng , Li Bin 
Published: October 2022

Abstract
Background: Nuss procedure is rarely used in young children. The application of subcutaneous sternal suspension (SSS) in low-collar children solves this embarrassment. This study aims to compare the safety and feasibility of subcutaneous sternal suspension and Nuss operation in the treatment of pectus excavatum.
Methods: 69 patients with pectus excavatum surgery from 2013 to 2022 were included. The patients were divided into two groups according to surgical method: SSS group and Nuss group. Comparing basic information and perioperative complications to evaluate the feasibility and safety of two groups.
Results: 44 patients in Nuss group had removed steel bars and 4 patients in SSS group. The average age of the SSS group was significantly lower than that of the Nuss group (P=0.0001). There were no significant differences in other baseline information such as gender, Haller index, symmetry and comorbidities. The SSS group was better than the Nuss group in the comparison of blood loss(P=0.22), postoperative hospital stays(P=0.003), operation time(P=0.0001). There was no significant difference in the complications between the two groups.
Conclusions: SSS surgery is more suitable for low-collar patients (3years old and above) because of the advantages fast recovery. Thus, this method requires longer follow-up to observe its long-term therapeutic effect.
Identification of Causal Pathways among Gut Microbiota, Food Intake and Telomere Length: A Mendelian Randomization Study
Authors: Hou Lei , Yu Yuanyuan , Jin Chuandi , Zhang Lei , Ge Yilei , Liu Xinhui , Wu Sijia , Qian Fengtong , Wu Yutong , Yu Yifan , Luo Qingxin , He Yina , Feng Yue , Wei Yun , Li Hongkai , Xue Fuzhong 
Published: October 2022

AbstractBackground: Dietary habit plays an important role in the composition and function of gut microbiota which possibly manipulates host eating behavior. Gut microflora and nutritional imbalance are associated with telomere length (TL). However, the causality among them remains unclear. We aim to explore the causal pathways among gut microbiota, food intake (FI) and TL.Results:Firstly, we calculate the significance threshold based on genetic correlations.Then we perform bi-directional Mendelian Randomization (MR) analyses among 82 FIs (UK Biobank, N=455,146), 95 gut microbial traits (Flemish Gut Flora Project, N=2,223) and TL (genome-wide meta-analysis from 15 cohorts, N=37,684) using summary-level data from large genome-wide association studies. Fixed-effect inverse variance weighting is the main analysis method and the other eight two-sample MR methods and three sensitivity analyses are performed. Several bi-directional causal relationships among gut microbiota, FIs and TL are obtained by two-sample MR. Overall, we find suggestive evidence of three main causal pathways among them. Drinking more glasses of water per day is able to affect the habit of eating dried fruit through the host gut microbiota (Barnesiella). The change of one gut microbiota taxon (Collinsella) in the host causally influences another gut microbiota taxon (Lactonccus) through the diet habits (intake of oil-based spread). Additionally, the TL alters the habits of drinking ground coffee and further affects the gut microbiota (Acidaminococcaceae). Finally, GO enrichment analyses are used to investigate the bio-function and confirm the MR results.Conclusions: TL has an impact on diet habits and gut microbiota and there are bi-directional relationships between diet habits and gut microbiota.
Evaluation of Automated Sample Preparation System for Lymph Node Sampling
Authors: Duke Jennifer D. , Sturgis Charles D. , Hartley Christopher , Bailey Morgan , Reid Michal , Kern Ryan , Bluestone Alex , Subramanian Hariharan , Reisenauer Janani 
Published: October 2022

Abstract
Purpose: The purpose of this study was to evaluate the feasibility and specimen quality of lymph node biopsies prepared through a novel automated system for automated fixation, drying and staining compared to standard slide preparation method.
Methods: We performed a prospective, single-center study of patients undergoing endobronchial ultrasound. Samples were split into conventional standard of care (SOC) slide preparation and preparation using the device (ASP). Pathologists compared the SOC slides to the slides prepared by the automated system and assessed the following metrics: nuclear and cytoplasmic quality, presence of debris/artifact, staining quality, creation of a monolayer, and ease of adequacy/diagnosis assessment. A score between 1 (lowest quality) and 3 (highest quality) was assigned to the above metrics.
Results: 60 patients were recruited. One to three lymph nodes were sampled for each patient with a total of 73 samples collected. The mean scores of each assessment category showed no statistical difference between the two preparation techniques except for improved monolayer creation in the ASP samples. All samples showed diagnostic equivalency between the automated slides and conventional slides except for one which was reported to be suspicious on the ASP sample and atypical on the SOC.
Conclusion: Study results suggest that slides prepared by the automated system are of adequate quality for adequacy assessment with diagnostic concordance when compared to SOC slides.