bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Improvement of Survival for Alveolar Rhabdomyosarcoma Patients After HLA-Matched Versus -Mismatched Allogeneic Hematopoietic Stem Cell Transplantation Compared to Standard-of-Care Therapy
Authors: Schober Sebastian Johannes , Hallmen Erika , Reßle Florian , Gassmann Hendrik , Prexler Carolin , Wawer Angela , von Luettichau Irene , Ladenstein Ruth , Kazanowska Bernarda , Ljungman Gustaf , Niggli Felix , Lohi Olli , Hauer Julia , Gruhn Bernd , Klingebiel Thomas , Bader Peter , Burdach Stefan , Lang Peter , Sparber-Sauer Monika , Koscielniak Ewa , Thiel Uwe 
Published: May 2022

BackgroundPatients with stage IV alveolar rhabdomyosarcoma (RMA) have a 5-year-survival rate not exceeding 30%. Here, we assess the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for these patients in comparison to standard-of-care regimens. We also compare the use of HLA-mismatched vs. HLA-matched grafts after reduced vs. myeloablative conditioning regimens, respectively.Patients and MethodsIn this retrospective analysis, we compare event-free survival (EFS), overall survival (OS), and toxicity of HLA-mismatched vs. -matched transplanted patients in uni- and multivariate analyses (total: n = 50, HLA-matched: n = 15, HLA-mismatched: n = 35). Here, the factors age at diagnosis, age at allo-HSCT, sex, Oberlin score, disease status at allo-HSCT, and HLA graft type are assessed. For 29 primarily transplanted patients, three matched non-transplanted patients per one transplanted patient were identified from the CWS registry. Outcomes were respectively compared for OS and EFS. Matching criteria included sex, age at diagnosis, favorable/unfavorable primary tumor site, and metastatic sites.ResultsMedian EFS and OS did not differ significantly between HLA-mismatched and -matched patients. In the mismatched group, incidence of acute GvHD was 0.87 (grade III–IV: 0.14) vs. 0.80 in HLA-matched patients (grade III–IV: 0.20). Transplant-related mortality (TRM) of all patients was 0.20 and did not differ significantly between HLA-mismatched and -matched groups. A proportion of 0.58 relapsed or progressed and died of disease (HLA-mismatched: 0.66, HLA-matched: 0.53) whereas 0.18 were alive in complete remission (CR) at data collection. Multivariate and competing risk analyses confirmed CR and very good partial response (VGPR) status prior to allo-HSCT as the only decisive predictor for OS (p &lt; 0.001). Matched-pair survival analyses of primarily transplanted patients vs. matched non-transplanted patients also identified disease status prior to allo-HSCT (CR, VGPR) as the only significant predictor for EFS. Here, OS was not affected, however.ConclusionIn this retrospective analysis, only a subgroup of patients with good response at allo-HSCT survived. There was no survival benefit of allo-transplanted patients compared to matched controls, suggesting the absence of a clinically relevant graft-versus-RMA effect in the current setting. The results of this analysis do not support further implementation of allo-HSCT in RMA stage IV patients.
Investigating Effect of Coherent Emission Length on Pion Interferometry in High-Energy Collisions Using a Multiphase Transport Model
Authors: Wang Shi-Yao , Zhang Wei-Ning 
Published: May 2022

We study the two-pion Hanbury Brown–Twiss correlation functions for a partially coherent source constructed with the emission points and momenta of the identical pions generated by a multiphase transport model. A coherent emission length is introduced, the effects of which on the two-pion interferometry results in central Au-Au collisions at sNN=200 GeV, central Pb-Pb collisions at sNN=2.76 TeV, and p-p collisions at s=13 TeV are investigated. It is found that the effect of coherent emission length reduces the two-pion correlation functions in the nucleus–nucleus collisions, leading to an average decrease of chaoticity parameter by approximately 15% in the high transverse momentum range. However, the influence of coherent emission length on the two-pion correlation functions in the p-p collisions is small, while the effect of coherent emission length on the chaoticity parameter is almost independent of the transverse momentum of pion pair in the p-p collisions.
Development of Functional Fitness Prediction Equation in Korean Older Adults: The National Fitness Award 2015–2019
Authors: Kim Sung-Woo , Park Hun-Young , Jung Hoeryong , Lim Kiwon 
Published: May 2022

The main advantage of measuring functional fitness (FF) in older adults is that individual tests can estimate and track the rate of decline with age. This study aimed to develop a multiple linear regression model for predicting FF variables using easy-to-measure independent variables (e.g., sex, age, body mass index, and percent body fat) in Korean older adults. National Fitness Award datasets from the Republic of Korea were used in this analysis. The participants were aged ≥65 years and included 61,465 older men and 117,395 older women. The FF variables included the hand grip strength, lower body strength (30-s chair stand), lower body flexibility (chair sit-and-reach), coordination (figure of 8 walk), agility/dynamic balance (timed up-and-go), and aerobic endurance (2-min step test). An estimation multiple linear regression model was developed using a stepwise technique. In the regression model, the coefficient of determination in the hand grip strength test (adjusted R2 = 0.773, p &lt; 0.001) was significantly high. However, the coefficient of determination in the 30-s chair stand (adjusted R2 = 0.296, p &lt; 0.001), chair sit-and-reach (adjusted R2 = 0.435, p &lt; 0.001), figure of 8 walk (adjusted R2 = 0.390, p &lt; 0.001), timed up-and-go (adjusted R2 = 0.384, p &lt; 0.001), and 2-min step tests (adjusted R2 = 0.196, p &lt; 0.001) was significantly low to moderate. Our findings suggest that easy-to-measure independent variables can predict the hand grip strength in older adults. In future studies, explanatory power will be further improved if multiple linear regression analysis, including the physical activity level and nutritional status of older adults, is performed to predict the FF variables.
Mental Health Among Medical Students During COVID-19: A Systematic Review and Meta-Analysis
Authors: Jia Qingwen , Qu Yi , Sun Huiyuan , Huo Huisheng , Yin Hongxia , You Dianping 
Published: May 2022

BackgroundThe mental health of medical students is an issue worthy of attention, especially during COVID-19. Many studies have shown that depression and anxiety are the main problems faced by medical students. To assess the pooled prevalence of depression and anxiety among medical students worldwide, we conducted this meta-analysis.MethodsAccording to PRISMA, we used a computerized strategy to search studies in EMBASE, PubMed, PsycArticles, Web of Science, and China Biology Medicine disc. The pooled prevalence of depression and anxiety was calculated by a random-effects model. Heterogeneity was explored by subgroup analysis. Sensitivity analysis and publication bias were also carried out in this meta-analysis.ResultsOf 1316 studies, 41 studies were selected based on 36608 medical students. The pooled depression prevalence was 37.9% (95% CI: 30.7–45.4%), and pooled anxiety prevalence was 33.7% (95% CI: 26.8–41.1%). The prevalence of depression and anxiety among medical students varied by gender, country, and continent.ConclusionThe data reported that the prevalence of depression and anxiety among medical students during COVID-19 was relatively higher than those of the general population and the healthcare workers. The impact of COVID-19 on medical students and how to protect the mental health of medical students are needed to determine through further research.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021274015], identifier [CRD42021274015].
Fear and Challenges of Nursing Students Being in Hospital for Clinical Posting During the COVID-19 Pandemic: An Exploratory Survey
Authors: Rana Nimarta , Kalal Nipin , Sharma Suresh K. 
Published: May 2022

BackgroundThe world is facing unprecedented challenges in the face of a global pandemic (COVID-19). The institutions resumed nursing students’ clinical experiences as an earlier part of their curriculum, which was transitioned to a virtually delivered format due to global disaster. Therefore, working through this pandemic in hospital posting is challenging and fearful for nursing students. The aim of this study was to measure the fear of COVID-19 and the challenges faced by nursing students when posted in hospitals during the COVID-19 pandemic.MethodsA web-based exploratory survey was conducted on 185 participants from March 2021 to April 2021. Participants were selected through a web-based survey (Google form) by non-probability purposive sampling technique. The Fear of COVID-19 Scale and self-structured questionnaires with the Likert-type scale were used to measure the fear of COVID-19 and the challenges faced by nursing students when posted in hospitals during the COVID-19 pandemic, respectively. Descriptive and inferential statistics were used for the analysis of data with IBM SPSS version 27.ResultsA significant number (61.1%) of participants had moderate fear of COVID-19 infection, one-third of them (28.1%) had mild fear, and very few participants (10.8%) had an extreme fear of COVID-19 infection. The majority of participants (64.9%) faced moderate challenges, 27% faced high challenges, and very few study participants (8.1%) did not face any challenges when posted in the hospital during the COVID-19 pandemic. The fear due to COVID-19 is not associated with demographic variables, but the challenges faced due to COVID-19 are significantly associated with demographic variables, such as the age, batch, and duration of clinical posting (p-value = 0.01).ConclusionStudy data indicated that respondents reported fear of COVID-19 infection and also experienced a variety of challenges in hospital posting during the COVID-19 pandemic.
Attitudes Toward HPV Vaccination in Sweden: A Survey Study
Authors: Wemrell Maria , Gunnarsson Lena 
Published: May 2022

BackgroundWhile HPV vaccination uptake in Sweden is quite high, at around 80%, vaccine hesitancy remains an issue in countries throughout Europe. The latter can be related to a contemporary context of increased contestation of expert knowledge and of a large share of information on health-related issues including vaccination today being sought via the internet. Still, there is a paucity of recent research on attitudes toward the HPV vaccine in a larger sample of the population in Sweden. This survey study assesses such attitudes and any correlations between vaccine hesitancy and sociodemographic characteristics, trust in healthcare and other societal institutions, and evaluation of the reliability of different sources of information.MethodsThe validated survey questionnaire was distributed to adult women in Sweden (n = 2,000), via a nationally representative web panel. The response rate was 37%. Aside from descriptive statistics, associations between vaccine hesitancy and sociodemographic and other variables were computed using logistic regressions and expressed as odds ratios (ORs) with 95% confidence intervals (95% CIs).ResultsOur results show a positive attitude toward HPV vaccination overall. Still, some degree of HPV vaccine hesitancy was indicated by 33.8% of the respondents, and more pronounced hesitancy by 7.6%. Regarding vaccination in general, a very positive attitude was indicated by 55%. HPV vaccine hesitancy was associated with low education and low income and strongly associated with a lack of confidence in healthcare and other societal institutions. It was also correlated with a self-assessed lack of access to, and ability to assess the origin, quality and reliability of, information about the HPV vaccine.ConclusionEfforts to provide transparent information about HPV vaccination should be combined with healthcare providers being open to discuss vaccine concerns with patients and avoiding practices that do not promote trust.
The Association of Body Mass Index With Mortality Among Pulmonary Hypertension Patients: A Systematic Review and Meta-Analysis of Cohort Studies
Authors: Jiang Chaoxin , Fang Xiongde , Fu Wenjin 
Published: May 2022

ObjectiveTo run a systematic review and meta-analysis of related studies on body mass index (BMI) and the risk of death among pulmonary hypertension (PH) patients, as well as, to shed light on the shape and strength of the dose-response association.MethodsStudies published up to Jun 2021 in scientific databases such as Scopus, and PubMed as well as Google Scholar were searched. Cohort studies that reported risk estimates for at least two categories of BMI or per certain increase in BMI in relation to mortality in PH patients were included. Summary relative risks were determined with random effects models. Non-linear relationship was discovered with dose-response analysis.ResultsAll in all, 15 cohort studies were selected. The number of participants was 127,215 out of which 73,999 were reported dead. The summary RR for mortality per a 5-unit increment in BMI was 0.83 (95% confidence interval 0.77–0.89; I2 = 75.6%, n = 9) among PH patients. There was a non-linear dose-response relation between BMI and mortality in PH patients (Pnon−linearity &lt; 0.001), with the lowest risk being at BMI 32–38 kg/m2.ConclusionHigher BMI is related to decreased risk of mortality among PH patients and the lowest point of the curve was seen at BMI 32–38.
Use of Implementation Mapping With Community-Based Participatory Research: Development of Implementation Strategies of a New Goal Setting and Goal Management Intervention System
Authors: Kang Eunyoung , Foster Erin R. 
Published: May 2022

AimsThis study aims to identify implementation determinants, mechanisms of action, implementation strategies, and implementation outcome evaluation plans for a new theory-based rehabilitation goal setting and goal management intervention system, called MyGoals, using Implementation Mapping with community-based participatory research principles.MethodsWe completed Implementation Mapping tasks 1 to 4 as a planning team consisting of MyGoals target implementers (occupational therapists (OTs), MyGoals intervention target clients (adults with chronic conditions), and the research team. We are currently conducting mapping task 5. These processes were guided by the Consolidated Framework for Implementation Research, social cognitive theory, the taxonomy of behavior change methods, and Proctor's implementation research framework.ResultsWe identified intervention-level determinants (MyGoals' evidence strength &amp; quality, relative advantages) and OT-level determinants (knowledge, awareness, skills, self-efficacy, outcome expectancy). We selected the MyGoals implementation outcome (OTs will deliver MyGoals completely and competently), outcome variables (acceptability, appropriateness, feasibility, fidelity), and process outcomes. We also determined three performance objectives (e.g., OTs will deliver all MyGoals intervention components) and 15 change objectives (e.g., OTs will demonstrate skills for delivering all MyGoals intervention components). Based on the identified outcomes, objectives, and determinants, we specified the mechanisms of change (e.g., active learning). To address these determinants and achieve the implementation outcomes, we produced two tailored MyGoals implementation strategies: MyGoals Clinician Education and MyGoals Clinician Audit &amp; Feedback. We developed evaluation plans to explore and evaluate how these two MyGoals implementation strategies perform using a mixed-methods study of OT-client dyads.ConclusionWe produced tailored implementation strategies for a rehabilitation goal setting and goal management intervention by using Implementation Mapping with community-based participatory research principles. The MyGoals implementation strategies may help OTs implement high-quality goal setting and goal management practice and thus contribute to bridging current research-practice gaps. Our findings can provide insight on how to apply implementation science in rehabilitation to improve the development and translation of evidence-based interventions to enhance health in adults with chronic conditions.
Association Between Cytomegalovirus Serostatus, Antiviral Therapy, and Allograft Survival in Pediatric Heart Transplantation
Authors: Rabbani Naveed , Kronmal Richard A. , Wagner Thor , Kemna Mariska , Albers Erin L. , Hong Borah , Friedland-Little Joshua , Spencer Kathryn , Law Yuk M. 
Published: May 2022

Background: Cytomegalovirus (CMV) is an important complication of heart transplantation and has been associated with graft loss in adults. The data in pediatric transplantation, however, is limited and conflicting. We conducted a large-scale cohort study to better characterize the relationship between CMV serostatus, CMV antiviral use, and graft survival in pediatric heart transplantation.Methods: 4,968 pediatric recipients of solitary heart transplants from the Scientific Registry of Transplant Recipients were stratified into three groups based on donor or recipient seropositivity and antiviral use: CMV seronegative (CMV-) transplants, CMV seropositive (CMV+) transplants without antiviral therapy, and CMV+ transplants with antiviral therapy. The primary endpoint was retransplantation or death.Results: CMV+ transplants without antiviral therapy experienced worse graft survival than CMV+ transplants with antiviral therapy (10-year: 57 vs 65%). CMV+ transplants with antiviral therapy experienced similar survival as CMV- transplants. Compared to CMV seronegativity, CMV seropositivity without antiviral therapy had a hazard ratio of 1.21 (1.07–1.37 95% CI, p-value = .003). Amongst CMV+ transplants, antiviral therapy had a hazard ratio of .82 (0.74–.92 95% CI, p-value &lt; .001). During the first year after transplantation, these hazard ratios were 1.32 (1.06–1.64 95% CI, p-value .014) and .59 (.48–.73 95% CI, p-value &lt; .001), respectively.Conclusions: CMV seropositivity is associated with an increased risk of graft loss in pediatric heart transplant recipients, which occurs early after transplantation and may be mitigated by antiviral therapy.
Creating a Single Inflow Orifice From Living Donor Kidney Allografts With Multiple Renal Arteries
Authors: Tabbara Marina M. , Guerra Giselle , Riella Juliano , Abreu Phillipe , Alvarez Angel , Vianna Rodrigo , Chen Linda , Morsi Mahmoud , Gaynor Jeffrey J. , Gonzalez Javier , Ciancio Gaetano 
Published: May 2022

Background: Multiple renal arteries (MRA) are often encountered during living-donor kidney transplantation (LDKT), requiring surgeons to pursue complex renovascular reconstructions prior to graft implantation. With improvements in reconstruction and anastomosis techniques, allografts with MRA can be successfully transplanted with similar outcomes to allografts with a single renal artery. Here, we describe in detail various surgical techniques for reconstruction of MRA grafts with the intent of creating a single arterial inflow.Methods: We retrospectively reviewed the medical records of all LDKT recipients with laparoscopically procured MRA kidneys between March 2008 and July 2021. Recipient and donor characteristics, operative data, type of reconstruction, and recipient outcomes were analyzed. The primary outcomes were the incidence of developing delayed graft function (DGF) and/or a vascular or urological complication within 12 months post-transplant.Results: Seventy-three LDKT recipients of MRA donor allografts were evaluated. Two renal arteries (RA) were encountered in 62 allografts (84.9%) and three RA in 11 allografts (15.1%). Renal artery reconstruction was performed in 95.8% (70/73) of patients. Eighteen different reconstruction techniques of MRA were utilized, the most common being side-to-side anastomosis in allografts with two RA (N = 44) and side-to-side-to-side anastomosis in allografts with three RA (N = 4). Interposition grafting was performed in seven cases (9.6%). A single ostium was created in 69 cases (94.5%), and the median warm ischemia time was 27 (range 20–42) minutes. None of the patients developed DGF or post-operative vascular or urological complications. Median creatinine at 3, 6, and 12 months post-transplant remained stable at 1.1 mg/dl. With a median follow-up of 30.4 months post-transplant, only one graft failure has been observed–death-censored graft survival was 98.6%.Conclusion: Complex reconstruction techniques to create a single renal artery ostium for graft implantation anastomosis in allografts with MRA show acceptable warm ischemic times, with no increased risk of post-operative vascular or urological complications.
PENGARUH BUKU SAKU GIZI KESEHATAN REPRODUKSI TERHADAP MINAT PENCEGAHAN ANEMIA PADA WANITA PEKERJA
Authors: Mamat Mamat , Mardianti Mardianti 
Published: May 2022

Penyebab terjadinya kasus anemia terjadinya karena kurang pengetahuan. Media buku saku merupakan salah satu alternafir memenuhi kebutuhan kekurangan pengetahuan . Tujuan penelitian ini mengetahui pengaruh buku saku gizi kesehatan reproduksi terhadap persepsi perilaku, norma subyektif, sikap dan minat perilaku pencegahan anemia pada wanita pekerja. Desain yang digunakan adalah quossi eksperimen dengan control grup. Sampelnya wanita pekerja diambil secara pupossive random sampling. Besar sampel sebanyak 119 terbagi dalam 2 kelompok yaitu kelompok intervensi (54 sampel) dan dan 65 sampel sebagai kelompok kontrol. Buku saku yang digunakan untuk intervensi telah disusun dan dikaji berdasarkan kebutuhan serta kajian ahli. Data yang dikumpulkkan mengacu pada teori Theory of Planded Behavior (TPB), diambil secara online meliputi perpesi kendali perilaku, norma subyektif dan sikap serta minat perilaku pencegahan anemia. Data diolah dengan program SPPS lalu dianalisis dengan uji t independent hasilnya menunjukkan terdapat pengaruh buku saku terhadap persepsi kendali perilaku, norma subyektif dan sikap, yang tergambar beda nilai rata rata persepsi kendali perilaku lebih besar pada kelompok intervensi 1,56 poin , norma subyektif sebesar 2,2 poin dan skor sikap sebesar 3,0 poin dibanding kelompok kontrol dimana ketiganya memiliki nilai p 0,01. Terdapat pengaruh buku saku terhadap minat dengan perbedaan rata rata minat minat sebesar 1,33 poin lebih besar kelompok intervensi dibanding kelompok kontrol dengan nilai p sebesar 0,001. Mengacu pada hasil pengembangan media perlu ditingkatkan dalam bentuk online seperti E-book dan media informasi lainnya serta perlu ada kolaborasi dan kordinasi dengan intansi terkait
The Candidate Training Impact Towards Participants’ Cognitive and Behavior of Mental Illness Early Detection
Authors: Susanti Susi , Avianti Nani , Muryati Muryati 
Published: May 2022

This study is to reveal the impact of the candidate training of mental illness early detection to participants’ cognitive and behaviour towards mental illness detection. It is expected that participants able to recognize the symtomp of mental illness and detect in early stage to tackle it. The candidate could identify as part of mental health service then report this to the nearest Puskesmas. This would solve some problems of mental health in community in detecting the indication that occurs and influence the community in 10 hamlets which have 24 integrated healthcare centre covered 25.753 population. This big sub-district that lays near education area and having immigrant from other areas has potential to raise the psychosocial problems as mental illness.The research population is 80 of participants or candidates by proportional sampling and use quasi-experimental dengan one group pretest and posttest design. The statistic test used is Wilcoxon Signed Ranks Test to test the candidates’ cognitive and pairs sample t for candidates’ behavior. The result showed that candidates’ cognitive increased significantly after they discussed in small groups with the module of early detection (Pvalue = 0,000<0,05). The behavior has increased significantly as well with the same method (Pvalue = 0,008<0,05).