bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEMOSTIMULATING PROPERTIES OF THE CONJUGATES OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR WITH ALENDRONIC ACID
Authors: Shimina G. G. , Bateneva A. V. , Tsyplenkova E. S. , Gamaley S. G. , Esina T. I. , Volosnikova E. A. , Danilenko E. D. 
Published: December 2022

The aim of the work is to evaluate the hemostimulating activity of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) conjugates with alendronic acid (ALN) in the model of cytostatic myelosuppression and the dynamics of rhGM-CSF accumulation as a part of the conjugate in the bone tissue and bone marrow of mice.Materials and methods. The conjugates obtained by a solid-phase synthesis using 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide or periodate oxidation, were used. A hemostimulating activity was evaluated in a model of a cytostatic myelosuppression induced by the administration of cyclophosphamide to CBA/Calac mice. RhGM-CSF preparations were injected subcutaneously for 4-5 days at the dose of 90 µg/kg. After the injections cycle had been completed, the total leukocyte and segmented neutrophil counts were carried out in the blood samples, and the total karyocyte count was carried out in the bone marrow samples.The tissue distribution of rhGM-CSF preparations was assessed in outbred CD-1 mice after a single intravenous administration at the effective dose. The content of rhGM-CSF in blood, femoral tissue and bone marrow was determined by enzyme immunoassay.Results. RhGM-CSF conjugates with ALN have been shown to retain the ability of the original protein to increase the number of leukocytes, segmented blood neutrophils, and bone marrow karyocytes under the action of conjugates. The stimulation of the neutrophil production used to be observed at earlier times than in the case of rhGM-CSF. The increase in the total number of bone marrow cells after the introduction of all three conjugates was more pronounced compared to the original protein (by 34%). The increased hemostimulatory effect of the AEG conjugate was accompanied by a more intense accumulation of rhGM-CSF in the bone tissue and bone marrow of mice. The rhGM-CSF introduced into the conjugate was detected in the bone tissue for 24 h and it circulated in the bloodstream for a longer time compared to the original protein.Conclusion. The data obtained make it possible to conclude that further work on the development of effective hemostimulating drugs based on rhGM-CSF conjugates with ALN, is promising.
Animal diseases and zoonoses at a municipal slaughterhouse in Southwest Nigeria: Three-year retrospective survey (2014–2016)
Authors: Adebowale Oluwawemimo Oluseun , Ekundayo Olugbemiga , Olasoju Mary , Oladejo Oladotun Oladipo , Awoseyi Ayomikun Abayomi 
Published: December 2022

Slaughterhouses are certified premises where animals are slaughtered and inspected to ensure meats are wholesome and safe for public consumption. To determine the common zoonoses encountered in a municipal slaughterhouse of Abeokuta, Ogun State, Nigeria, a three-year retrospective study was conducted (2014–2016). During the review of slaughterhouse records, the overall throughput of cattle slaughtered was 146,794 (4077.6 ± 413.6; 95% confidence interval [CI] 3923.3–4206.7). Female animal slaughtering outweighed male ones at 5:1 ratio (p < 0.0001). The highest number of cattle were slaughtered in December 2014, December 2015, and August 2016. Of all the total cattle slaughtered, the overall observed prevalences for bovine tuberculosis (BTB), hydatidosis and fasciolosis were estimated as 9514 (6.5%, 264.3 ± 81.7; 95% CI 236.6–291.9), 1851 (1.3%, 55.8 ± 17.3; 95% CI 49.9–61.6) and 845 (0.6%, median = 19.0; 95% CI 18.7–28.3), respectively. On average the highest number of BTB cases was reported in February-March, it declined slightly in October and increased again in November. Similarly, the highest numbers of hydatidosis and fasciolosis were observed in March and February, respectively. A significant (p = 0.02) mean variation of cases of BTB was found across the period and it was higher (p = 0.03) during the wet/rainy season in 2015. Our results emphasized the need to promote coordinated active surveillance for zoonoses detection and mitigation to ensure food safety at farm and slaughterhouse levels. Adequate record keeping for specific organ/meat/carcass condemnation is crucial at postmortem, as this represents a significant loss of animal proteins and revenues. Such data can be used for informed policy to intensify reduction in economic loss associated with animal diseases.
INOVASI PAKET WISATA DI DWH BILEBANTE DAN DWH SESAOT
Authors: Supardi  , Endang Wahyuni  , Dayu Utami  
Published: December 2022

Desa Wisata Hijau Bilebante Lombok Tengah dan Desa Wisata Hijau Sesaot adalah dua desa wisata yang memiliki sejarah yang sama dalam membangun dan mengembangkan desa wisata. DWH Bilebante pertama kali diideasi pembangunannya oleh koperasi Putri Renjani, sedangkan DWH Sesaot di ideasi dan dikembangkan pertama kali oleh Koperasi Sugeh Engger Sesaot, dimana dalam Koperasi tersebut terdapat unit usaha yaitu DWH yang bertugas untuk mengembangkan usaha pariwisata dalam rangka meningkatkan profit koperasi. DWH tersebut pada tahun 2014 difasilitasi oleh GIZ. Penelitian ini bertujuan untuk mengetahui bagaimana inovasi paket wisata DWH tersebut yang berarti penelitian ini menggambarkan bagaiman proses yang dilalui dalam melakukan inovasi paket wisata dan perencanaan produk yang dilakukan. Penelitian ini merupakan penelitian kualitatif. Acuan inovasi bersumber dari UU No 19 yaitu inovasi merupakan suatu kegiatan penelitian, pengembangan, dan atau perekayasaan yang dilakukan untuk pengembangan penerapan praktis nilai dan konteks ilmu pengetahuan yang baru, atau pun cara baru, dalam produk ataupun proses produksinya maka penelitian ini memandang proses dalam Research & Devlopment yang dikembangkan oleh Sugiono (2008:40) dapat digunakan untuk menggambarkan bagaimana inovasi paket wisata yang dilakukan oleh kedua DWH, yang dimulai dari menemukan potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, ujicoba produk, revisi produk, ujicoba produk, potensi dan masalah, produksi masal (pemasaran). Hasil dari penelitian ini yaitu bahwa DWH tersebut sudah melakukan berbagai inovasi paket wisata namun belum menerapkan untuk berinovasi produk paket wisata, mereka melakukan loncatan proses tampa melalui desain produk yang dibuat dalam BMC, sehingga produk yang dihasilkan belum desirability, feasibility, viability.
STRATEGI KEPEMIMPINAN KEPALA SEKOLAH PADA PENINGKATAN MUTU PENDIDIKAN DI SEKOLAH MENENGAH KEJURUAN
Authors: HAMDI MUHAMAD , Siti Istiningsih  
Published: December 2022

Penelitian ini bertujuan mengidentifikasi, menganalsis dan merefleksikan strategi kepepmimpinan Kepala Sekolah SMKN 1 (State Of Vocational Senior High School) Mataram pada peningkatan mutu penidikan keterkaitan dan kesepadanan (Link and Match). Hasil yang dicapai adalah tersusunnya startegi kepemimpinan kepala sekolah pada peningkatan mutu pendidikan. Penelitian ini mengggunakan pendekatan kualitatif dengan demikian pengumpulan data dilakukan melalui observasi, analisis dokumen, wawancara, dan melalui pengisian angket. Sejalan dengan proses pelaksanaannya, penelitian ini dapat dikembangkan untuk meningktakan mutu pembelajaran jenjang sekolah kejuruan. Secara akademis hasil penelitian ini dapat dijadikan sebagai acuan/pedoman untuk pengembangan pengelolaan pendidikan kejuruan secara holistik.
Pengembangan sekolah menjadi organusasi layanan pendidikan yang memiliki tradisi mutu yang terus menerus. Kepala sekolah sebagai pemimpin pembelajaran dan pemimpin organisasi perlu mengembangkakan budaya mutu agar sekolah dapat menjadi salah satu peningkatan. Temuan penelitian adalah meliputi tentang strategi kepemimpinan kepala sekolah pada peningkatan mutu pendidikan di SMKN 1 Mataram meliputi; 1) artikulasi visi dan misi SMKN 1 Mataram, 2) nilai-nilai kepemimpinan kepala sekolah SMKN 1 Mataram, 3) penghargaan di SMKN 1 Mataram , 4) hubungan sosial dan emosional di SMKN 1 Mataram, dan 5) Peningkatan mutu pendidikan Link and Match di sekolah meliputi; a) mutu layanan sekolah, b) mutu guru dan staf, c) peningkatan pembelajaran yang relevan.
STRATEGI PROMOSI HOTEL RESOR DI MASA PANDEMI COVID-19 (STUDI KASUS : PESONA ALAM RESORT AND SPA, BOGOR)
Authors: Limanto Edrick , Kusumaningrum Dewi Ayu 
Published: December 2022

Dalam masa pandemi virus Covid-19 ini semua sektor terkena imbasnya termasuk sektor pariwisata. Pandemi Covid-19 ini memberikan rasa takut dan khawatir akan penularannya yang cepat, selain itu juga dengan belum ditemukannya obat penangkal virus ini mengakibatkan orang-orang menjadi takut untuk beraktivitas keluar rumah. Didukung kebijakan pemerintah terhadap sektor pariwisata terkait pandemi ini juga mengakibatkan banyaknya tempat wisata dan akomodasi tutup sementara dan beberapa ada yang masih bertahan. Beberapa yang masih bertahan perlu membuat inovasi agar tempat wisata dan akomodasi tersebut tidak tutup juga. Beberapa akomodasi yang masih bertahan perlu membuat inovasi dalam strategi pemasaran agar akomodasi yang dikelola masih dapat terus bertahan ditengah pandemi. Tujuan penelitian ini yaitu untuk mengetahui Strategi Promosi Hotel Resor di Masa Pandemi Covid-19 (Studi Kasus : Pesona Alam Resort And Spa, Bogor). Penelitian ini metode kualitatif, dengan cara mengumpulkan data melalui observasi, wawancara dan dokumentasi dengan beberapa narasumber yang terkait dengan konsep ini. Salah satu bentuk dari inovasi strategi pemasaran yang dilakukan oleh Pesona Alam Resort And Spa, Bogor adalah konsep Work From Home dan Pay Now, Stay Later membuat orang-orang jenuh dan stress menjalani hari-harinya bekerja dan beraktivitas dari rumah. Maka dari itu ada beberapa hotel membuat inovasi dengan memberikan tawaran Work From Hotel guna memberikan solusi di tengah pandemi ini untuk bekerja dari luar rumah tetapi tetap aman terhindar dari penularan virus Covid-19. Didapatkan hasil konsep Work From Hotel menjadi opsi terbaik untuk menghilangkan rasa bosan dan stress setelah lama melakukan aktivitas di rumah saja atau Work From Home. Faktor keamanan dan penerapan protokol kesehatan pada industri hotel terutama hotel Pesona Alam Resort and Spa sudah dipercaya wisatawan untuk menginap. Hal penting yang ditawarkan konsep Work From Hotel adalah fasilitas kecepatan internet yang bagus bagi sang ayah atau pekerja didukung suasana hotel seperti pemandangan alam dan fasilitas hiburan bagi anak-anak sembari sang ayah bekerja daring. Promosi konsep Work From Hotel efektif melalui media sosial. Strategi pemasaran dengan konsep Pay Now, Stay Later diterapkan secara daring dan strategi ini tidak terlalu efektif karena melemahnya daya beli masyarakat, akan tetapi strategi ini dapat memberikan pemasukan untuk menutup biaya operasional sehingga hotel dapat terus bertahan di tengah pandemi.
PENGARUH PENERAPAN PROJECT BASED LEARNING MODEL PADA MATA PELAJARAN GREEN EDUCATION TERHADAP KEMAMPUAN BERPIKIR KREATIF VERBAL SISWA
Authors: - Tina , Istiqomah Nurul 
Published: December 2022

Project based learning model or PBL is a kind of learning model that organize learning which concern on project activity. Project activity give students independency to construct their knowledge and also engaging students in problems solving, so students will be more active in the learning process and able to develop students verbal creative thinking. The aim of this study was to analyze the effect of PBL model application of green education subject to the students creative verbal thinking. The research was conducted at SMA Al Muslim on May 2013. The method used was the quasi experiment research. Population was chosen by purposive sampling. The samples was chosen by simple random sampling were the XI Exact 2 grade students as experimental class and control class XI Exact 1 as much as 30 students. Instrumen used were test to the students creative verbal thinking and learning attainment observation sheets for experiment class and control class. The statistical calculation showed that the average score of students verbal creative thinking test of experimental class was 57.20, whereas the control group was 53.23. Test analysis used is the perquisite test from normality with the Kolmogorov-Smirnov test and homogeneity with F test. Based on calculations drived normally distribused data and homogeneous. The t test calculation showed that t calc > t table, (4.73 > 2.66) at Î± = 0.05, it was concluded that there is effect of PBL model on green education subject to the students verbal creative thinking of SMA Al Muslim.
Modeling Water Injectivity Tests under Multiple Rate Schedule: An Approximate Solution
Authors: Neto J. L. F. B. , Pesco S. , Barreto Jr A. B. 
Published: December 2022

Summary
An injectivity test consists of continuously injecting a phase (water or gas) into an oil-saturated reservoir during a period. According to the analysis of the wellbore pressure behavior, this procedure estimates reservoir parameters, such as permeability and skin factor, and the volume of recoverable oil. In this context, this study proposes an approximate analytical solution for the pressure behavior during a water injectivity test on a multilayer reservoir considering multiple injection flow rates. The accuracy of the proposed solution was evaluated through comparison with a commercial finite-difference-based flow simulator in different scenarios. The results indicate a considerable agreement between the data provided by the numerical simulator and the proposed model. In addition, we successfully estimated the equivalent reservoir permeability using the proposed model with satisfactory results.
Reconstructing bird trajectories from pressure and wind data using a highly optimised hidden Markov model
Authors: Nussbaumer Raphaël , Gravey Mathieu , Briedis Martins , Liechti Felix , Sheldon Daniel 
Published: December 2022

Abstract
1. Tracking technologies have widely expanded our understanding of bird migration routes, destinations, and underlying strategies. However, determining the entire trajectory of small birds equipped with lightweight geolocators remains a challenge. Statistical trajectory models that incorporate both flight behaviour and sensor information provide the most accurate estimates of a bird’s full trajectory.
2. We develop a highly optimized hidden Markov model (HMM) for reconstructing bird trajectories. The observation model is defined by pressure and, optionally, light measurements, while the movement model incorporates wind data to constrain consecutive positions based on realistic airspeeds. Due to the large state space, the computational requirements for HMM calculations are high and may exceed available memory. We prune the HMM states and transitions based on flight and observation constraints to efficiently model the entire trajectory.
3. The approach presented is based on a mathematically exact procedure and is fast to compute. We demonstrate how to compute: (1) the most likely trajectory, (2) the marginal probability map of each stopover, (3) simulated trajectories, and (4) the wind conditions (wind support/drift) encountered by the bird during each migratory flight.
4. We construct a version of an HMM optimized for reconstructing a bird’s migration trajectory based on lightweight geolocator data. The focus of this work is to render this approach easily accessible to researchers through the dedicated R package GeoPressureR (https://raphaelnussbaumer.com/GeoPressureR/).
Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap – A case report
Authors: Bota Olimpiu , Meier Friedegund , Garzarolli Marlene , Schaser Klaus-Dieter , Dragu Adrian , Taqatqeh Feras , Fritsche Hagen 
Published: December 2022

Abstract
Background: Extensive loss of soft tissue and bone due to neoplasia, trauma, or infection in extremities often leads to amputation.
Case presentation: We present the case of a 72-year-old female patient presenting with an extended cutaneous squamous cell carcinoma of the lower leg, developed on top of necrobiosis lipoidica. After achieving the R0 resection, a 26x20 cm soft tissue and 15 cm tibial bone defect resulted. The contralateral leg had been lost due to the same disease 18 years before. We achieved a successful reconstruction of the leg using a pedicled fibula transplantation, an extended anterolateral thigh perforator flap and an internal fixation with plate and screws. Two years after the original surgery the patient is relapse-free and mobile, with adequate function of the reconstructed foot.
Conclusions: Our case presented a unique combination of pedicled fibula transplantation and free extended ALT perforator flap to reconstruct an extensive defect after resection of a rare cSCC on top of NL. In selected cases, the boundaries of limb salvage can be pushed far beyond the current standards of treatment.
Musculoskeletal injury epidemiology of military recruits: a systematic review and meta-analysis.
Authors: Murphy Myles C. , Stannard Joanne , Sutton Vanessa R. , Owen Patrick J. , Park Brendon , Chivers Paola T. , Hart Nicolas H. 
Published: December 2022

Abstract
Background: Injuries are a common occurrence in military recruit training, however due to differences in the capture of training exposure, injury incidence rates are rarely reported. Our aim was to determine the musculoskeletal injury epidemiology of military recruits, including a standardised injury incidence rate.
Methods: Epidemiological systematic review following the PRISMA 2020 guidelines. Five online databases were searched from database inception to 5th May 2021. Prospective and retrospective studies that reported data on musculoskeletal injuries sustained by military recruits after the year 2000 were included. We reported on the frequency, prevalence and injury incidence rate. Incidence rate per 1000 training days (Exact 95% CI) was calculated using meta-analysis to allow comparisons between studies. Observed heterogeneity (e.g., training duration) precluded pooling of results across countries. The Joanna Briggs Institute Quality Assessment Checklist for Prevalence Studies assessed study quality.
Results: This review identified 41 studies comprising 451,782 recruits. Most studies (n=26; 63%) reported the number of injured recruits, and the majority of studies (n=27; 66%) reported the number of injuries to recruits. The prevalence of recruits with medical attention injuries or time-loss injuries was 22.8% and 31.4%, respectively. Meta-analysis revealed the injury incidence rate for recruits with a medical attention injury may be as high as 19.52 injuries per 1000 training days; and time-loss injury may be as high as 3.97 injuries per 1000 training days. Longer recruit training programs were associated with a reduced injury incidence rate (p=0.003). The overall certainty of the evidence was low per a modified GRADE approach.
Conclusion: This systematic review with meta-analysis highlights a high musculoskeletal injury prevalence and injury incidence rate within military recruits undergoing basic training with minimal improvement observed over the past 20 years. Longer training program, which may decrease the degree of overload experienced by recruit, may reduce injury incidence rates. Unfortunately, reporting standards and reporting consistency remain a barrier to generalisability.
Systematic Review Registration: PROSPERO (Registration number: CRD42021251080)
The role of parental health beliefs in seeking an eye examination for their child
Authors: Masarwa Dua , Niazov Yulia , Natan Merav Ben , Mostovoy Dina 
Published: December 2022

Abstract
Background
We aimed to explore the role of parental health beliefs in parent seeking of eye examinations for their children, using the Health Belief Model.
Methods
In this quantitative correlational survey study, 100 parents who presented to Barzilai University Medical Center in July 2021 to perform an eye examination to their child completed a questionnaire.
Results
Only 29.6% of the parents knew that a vision screening is performed in first grade, and 10% of the parents did not know where to access eye care for their child. Moreover, 19% of the parents indicated that they were concerned that their child would be prescribed glasses unnecessarily, and 10% believed that wearing glasses would weaken their child's eyes. Various parental health beliefs regarding children’s eye examinations were found associated with parent seeking of eye examinations for their child. Thus, perceived susceptibility (r = 0.52, p < 0.01), perceived benefits (r = 0.39, p < 0.01), and perceived barriers (r=-0.31, p < 0.01) are associated with parent seeking of eye examinations for their child. Also, parents' level of knowledge was associated with seeking eye examinations for their child (r = 0.20, p < 0.01).
Conclusion
Parent perceptions of the child’s susceptibility to vision problems and perceived barriers to seeking eye examinations predicted parents seeking of eye examinations for their child. Interventions aimed at increasing timely eye examinations among children should focus on raising parent awareness of vision problems in childhood, dispelling misconceptions, and providing parents with practical information regarding available services.
Prophylactic Effect of retromuscular mesh during Loop Ileostomy closure On incisional herNia incidence – a multicentre randomized patient- and observer-blind trial (P.E.L.I.O.N Trial).
Authors: Müller Sven , Weyhe Dirk , Herrle Florian , Horvath Philipp , Bachmann Robert , von Ehrlich-Treuenstätt Viktor , Heger Patrick , Nasir Nadir , Klose Christina , Ritz Alexander , Sander Anja , Grohmann Erich , Dörr-Harim Colette , Mihaljevic Andre L. 
Published: December 2022

Abstract
Background: Incisional hernia is a frequent complication following loop ileostomy reversal. Incisional hernias are associated with morbidity, loss of health-related quality of life and costs and warrants the investigation of prophylactic measures. Prophylactic mesh implantation at the time of surgical stoma reversal has shown to be a promising and safe method to prevent incisional hernias in this setting. However, the efficacy of this method has not yet been investigated in a large multicentre RCT with adequate external validity. The P.E.L.I.O.N. trial will evaluate the efficacy of prophylactic mesh reinforcement after loop ileostomy closure in decreasing the rate of incisional hernia versus standard closure alone
Methods: P.E.L.I.O.N. is a multicentre, prospective, randomized, patient- and observer-blind trial. Patients undergoing loop ileostomy closure will undergo intraoperative 1:1 randomization into either abdominal wall closure with a continuous slowly absorbable suture in small stitch technique without mesh reinforcement (control group) or abdominal wall closure with an additional reinforcement with a retromuscular non-absorbable, macro-pore (pore size ³ 1000 μm or effective porosity >0%) light-weight monofilament or mixed structure mesh. A total of 304 patients (152 per group) will need to be randomised in the study. Based on inclusion and exclusion criteria, 1014 patients are expected to be screened for eligibility in order to recruit the necessary number of patients. Primary endpoint will be the frequency of incisions hernias within 24 months according to the European Hernia Society definition. Secondary endpoints will be the frequency of surgical site occurrences (including surgical site infections, wound seromas and hematomas and enterocutaneous fistulas), postoperative pain, the number of revisions surgeries and health-related quality of life. Safety will be assessed by measuring postoperative complications ≥ grade 3 according to the Dindo-Clavien Classification.
Discussion: Depending on the results of the P.E.L.I.O.N. trial prophylactic mesh implantation could become the new standard for loop ileostomy reversal.
Trial registration: DRKS00027921, U1111-1273-4657