bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of PCSK9 inhibition with evolocumab on lipoprotein subfractions in familial dysbetalipoproteinemia (type III hyperlipidemia)
Authors: Waldmann Elisa , Wu Liya , Busygina Kristina , Altenhofer Julia , Henze Kerstin , Folwaczny Alexander , Parhofer Klaus G. 
Published: March 2022

Background and aims
Familial dysbetalipoproteinemia (FDBL) is a rare inborn lipid disorder characterized by the formation of abnormal triglyceride- and cholesterol-rich lipoproteins (remnant particles). Patients with FDBL have a high risk for atherosclerotic disease. The effect of PCSK9 inhibition on lipoproteins and its subfractions has not been evaluated in FDBL.

Methods
Three patients (65±7 years, 23±3 kg/m2, 2 females) with FDBL (diagnosed by isoelectrofocusing) and atherosclerosis (coronary and/or cerebro-vascular and/or peripheral arterial disease) resistant or intolerant to statin and fibrate therapy received evolocumab (140mg every 14 days). In addition to a fasting lipid profile (preparative ultracentrifugation), apoB and cholesterol concentrations were determined in 15 lipoprotein-subfractions (density gradient ultracentrifugation; d 1.006–1.21g/ml) before and after 12 weeks of evolocumab treatment. Patients with LDL-hypercholesterolemia (n = 8, 56±8 years, 31±7 kg/m2) and mixed hyperlipidemia (n = 5, 68±12 years, 30±1 kg/m2) also receiving evolocumab for 12 weeks were used for comparison.

Results
All patients tolerated PCSK9 inhibition well. PCSK9 inhibitors reduced cholesterol (29–37%), non-HDL-cholesterol (36–50%) and apoB (40–52%) in all patient groups including FDBL. In FDBL, PCSK9 inhibition reduced VLDL-cholesterol and the concentration of apoB containing lipoproteins throughout the whole density spectrum (VLDL, IDL, remnants, LDL). Lipoprotein(a) was decreased in all patient groups to a similar extent.

Conclusions
This indicates that the dominant fraction of apoB-containing lipoproteins is reduced with PCSK9 inhibition, i.e. LDL in hypercholesterolemia and mixed hyperlipidemia, and cholesterol-rich VLDL, remnants and LDL in FDBL. PCSK9 inhibition may be a treatment option in patients with FDBL resistant or intolerant to statin and/or fibrate therapy.
Instituições públicas de formação da juventude campinense (1950-1960): democratização ou elitização?
Authors: Rodrigues Melânia Mendonça , Lima Niédja Maria Ferreira de , Silva Vívia de Melo 
Published: March 2022

Tratando de duas instituições públicas de ensino secundário de Campina Grande-PB, o Colégio Estadual da Prata (1953) e a Escola Normal Estadual (1960), o artigo discute o prestígio social das duas instituições, destacando as solenidades de inauguração dos prédios e o alunado de cada uma delas, nas respectivas primeiras décadas de funcionamento. Os achados provêm de matérias veiculadas em jornais do estado, bem como das fichas individuais dos alunos, disponíveis nos arquivos das instituições. A cobertura jornalística e a dimensão política das solenidades de inauguração dos prédios constituem forte indício do prestígio social do Colégio Estadual e da Escola Normal. Já o seu alunado foi constituído de jovens (rapazes e moças) oriundos de família tradicionais da elite campinense e regiões circunvizinhas. Tais achados permitem considerar que a trajetória das instituições, no período aqui analisado, evidencia a tensão entre elitização e democratização do ensino secundário campinense, nas décadas de 1950-1960.
ANTIBACTERIAL ACTIVITY FROM ETHANOL AND ETHYL ACETATE EXTRACTS OF Padina pavonica HAUCK FROM KABUNG ISLAND AGAINST Escherichia coli
Authors: Warsidah Warsidah , Safitri Ikha , Sofiana Mega Sari Juane , Helena Shifa 
Published: March 2022

Macroalgae is marine biological resources that play a crucial role and have an important economic value. They synthesize bioactive compounds with different kind of biological activities, such as antioxidant, antitumor, including antibacterial. In the health sector, infectious diseases from bacteria is one of the problems that still increasing. In addition, E. coli besides having the capacity to be pathogenic agent, it also showed mutlidrug resistence (MDR). Antibiotic resistance is a serious problem worldwide. The increase of this phenomenon leads to the exploration of new antibiotics using natural resources as an effort to overcome the problem. Padina pavonica Hauck belongs to Phaeophyceae spreeding along Kabung Island waters, but its existence has not been widely used. The objective of this study was to evaluate antibacterial activity from ethanol and ethyl acetate extract of P. pavonica Hauck from Kabung Island, West Kalimantan against E. coli. The extraction was made using ethanol and ethyl acetate solvents, and the antibacterial activity test was realized with concentration series of 5 ppm, 10 ppm, 15 ppm, and 20 ppm. The quantitative assessment of the antibacterial test showed that both ethanol and ethyl acetate extracts of P. pavonica Hauck had potential antibacterial activity against E. coli. The inhibition zone of ethanol extract was 11.6 mm, while ethyl acetate extract was 12.6 mm, respectively. These two solvents were included to the bacteriostatic category.
Connections between normalized Wright functions with families of analytic functions with negative coefficients
Authors: Joshi Santosh B. , Joshi Sayali S. , Pawar Haridas H. , Ritelli Daniele 
Published: March 2022

Abstract
In this article we present sufficient conditions that ensures that normalized Wright functions belong to certain subclasses of analytic univalent functions with negative coefficients in the unit disc

𝒰

{\mathcal{U}}

. We also provide some geometric properties of integral transforms involving normalized Wright functions.
Vertrauen und Misstrauen gegenüber Europa
Authors: Kavelashvili Nino , Šestović Vladimir 
Published: March 2022

Zusammenfassung
Die Debatte um die strukturierte Einbindung zivilgesellschaftlicher Netzwerke und Verbände in europäische Entscheidungsprozesse ist nicht neu. Trotz verschiedener Beteiligungsformate ist Handlungsbedarf im Hinblick auf nachhaltige Zusammenarbeit zwischen Politik und Zivilgesellschaft nicht zu übersehen. Der folgende Artikel geht der Frage nach, ob die organisierte Zivilgesellschaft die Rolle des Mittlers zwischen Bürger*innen und Institutionen übernehmen kann, wenn es darum geht, das Vertrauen in demokratische Verfahren und Institutionen zu stärken. Wie kann Zivilgesellschaft die eigene Stimme hörbar machen, wenn die Kanäle für den zivilen Dialog nicht funktionieren?
Pain, the brain, and SARS-CoV-2: evidence for pain-specific alterations in brain-related structure–function properties
Authors: Tesarz Jonas , Nees Frauke 
Published: March 2022

Abstract
According to best current estimates, approximately 10% of those infected with SARS-CoV-2-virus experience long-term clinical and nonspecific neurological symptoms that may last for several weeks or months. This is currently referred to as “Long-COVID” or “Post-COVID-Syndrome”. Based on current knowledge, the most common long-term symptoms of COVID-19 disease include fatigue and poor concentration, but particularly also headache and musculoskeletal pain. However, given the novelty of COVID-19, only a few studies have systematically evaluated the central nervous alterations in the pain processing structures of our brain. Those first insights are yet important in order to offer patients adequate therapeutic options. Based on a systematic review of the literature, we will therefore provide an overview of the central nervous alterations in the brain described in the context of SARS-CoV-2 infection, focusing on findings with brain imaging.
Estimated acceptable critical load values for the ecosystem at the Russian Far East using EANET monitoring data
Authors: Rychkova Anastasiya A. , Zhigacheva Ekaterina S. , Gromov Sergey A. 
Published: March 2022

Abstract
Natural ecosystems have become at risk due to the accelerating industrial and technological development over the past century accompanied by increasing pollutant emissions into the atmosphere. It realized mostly by means of matter overloads into nature areas caused by deposition of pollutants, especially sulfur and nitrogen oxides, which can significantly affect to change ecosystem state and on substance migration. The Critical Loads method is used to assess the sustainability of ecosystems exposed to atmospheric deposition. The corresponding maximum intake of sulfur and nitrogen is estimated based on the scheme of the stationary mass balance of ions in soil solutions. The critical loads were calculated for estimating the risk threshold of acid deposition for the ecosystem of the Russian Far East using the results of regular monitoring at the EANET Primorskaya station.
HCV genotype-specific drug discovery through structure-based virtual screening
Authors: Hussain Rashid , Khalid Hira , Fatmi Muhammad Qaiser 
Published: March 2022

Abstract

Hepatitis C Virus (HCV) poses great threat worldwide, and is a major cause for liver cancer. HCV genome encodes polyprotein that is subsequently cleaved into independently functioning proteins, which spread viral infection in host. The Non-Structural 3 (NS3) protease is responsible for cleaving the polyprotein, and may serve as a potential drug target. Since HCV has seven genotypes, the available drugs are predominantly designed for genotype 1 (GT1), and others prevalent in Europe. Consequently, these drugs lose efficacy when they are used for different genotypes. The current perspective study aims to find potential drug candidate against genotype 3 (GT3), prevalent in South Asia. The current study employed molecular docking technique and in silico ADME prediction tool to highlight potentially active compounds against HCV NS3 GT3. The study revealed Li_PIO_114 and Li_PIH_191 as potential lead compounds, as suggested by their docking score and ADME properties. These two compounds could be further optimized to improve their drug likeliness for curing HCV GT3.
Neurological and neuropsychological adverse effects of SARS-CoV-2 vaccines – where do we stand?
Authors: Aliasin Mohammad Mahdi , Yazdanpanah Niloufar , Rezaei Nima 
Published: March 2022

Abstract
The devastating characteristic of COVID-19 pandemic calls for immediate and effective solutions to tackle it. Vaccines seem to be the only promising and effective way to fight against the novel coronavirus – even against new mutated variants. Because of the rapid development and distribution of numerous COVID-19 vaccines in different platforms, meticulous evaluation of vaccines’ safety is more critical than ever – especially given the fact that most of the candidates have not completed the clinical phase. Therefore, to optimize the vaccines’ safety and efficacy, it is highly important to carefully report and scientifically discuss the serious adverse effects following vaccination. In this respect, we discuss different neurological and neuropsychological adverse effects of COVID-19 vaccines including demyelinating diseases, Bell’s palsy (BP), cerebrovascular complications, seizures, functional neurological disorders (FNDs), and some other rare adverse events, and hypothetical mechanisms which can lead to the reported side effects. Given the fact that the incidence of such events are rare and most of them are treatable, the current review aims to shed light on how much the relationship between COVID-19 vaccines and these complications can be reliable and provide an insight for future studies with much more meticulous methodologies to discuss the possible correlational or causal relationship between these complications and COVID-19 vaccines and elucidate whether or not the neurological side effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines can count as a considerable threat to public health.
Estimation and forecasting of long memory stochastic volatility models
Authors: Abbara Omar , Zevallos Mauricio 
Published: March 2022

Abstract
Stochastic Volatility (SV) models are an alternative to GARCH models for estimating volatility and several empirical studies have indicated that volatility exhibits long-memory behavior. The main objective of this work is to propose a new method to estimate a univariate long-memory stochastic volatility (LMSV) model. For this purpose we formulate the LMSV model in a state-space representation with non-Gaussian perturbations in the observation equation, and the estimation of parameters is performed by maximizing the likelihood written in terms derived from a Kalman filter algorithm. We also present a procedure to calculate volatility and Value-at-Risks forecasts. The proposal is evaluated by means of Monte Carlo experiments and applied to real-life time series, where an illustration of market risk calculation is presented.
Die Balanced Scorecard in der produzierenden Industrie
Authors: Horváth Péter , Gleich Ronald 
Published: March 2022

Abstract
In diesem Beitrag wird aufgezeigt, warum traditionelle, allein auf finanziellen Größen beruhende Konzepte zur Steuerung von Unternehmen und Geschäftsbereichen im heutigen dynamischen und turbulenten Wettbewerbsumfeld versagen. Mit dem Performance Measurement und besonders dem Balanced Scorecard-Konzept wird nachfolgend ein neuer, besonders in der amerikanischen Unternehmenspraxis bereits weitgehend akzeptierter Steuerungsansatz aufgezeigt und diskutiert.
Lebenszyklusorientiertes Informationsmanagement in der Anlagenplanung
Authors: Brüggemann Holger , Schimmelpfeng Katja , Seufzer Anette 
Published: March 2022

Abstract
Bereits während der Planungs- und Entwicklungsphase einer Anlage lassen sich verfügbarkeits-, qualitäts- und kostenbeeinflussende Faktoren determinieren. Dabei wird eine Vielzahl von Informationen erzeugt. Durch einen gezielten Zugriff auf diese kann in den nachgelagerten Phasen des Anlagenlebenszyklus (Betrieb, Entsorgung) die Verfügbarkeit der Anlage erhöht werden. Informationen und Erfahrungen aus diesen Phasen bilden für die Anlagenplanung ebenfalls eine wichtige Quelle.
Produktinformationssystem für Entwicklung, Fertigungsvorbereitung und Montage
Authors: Klose Johannes , Hahn Enrico , Steger Wolfgang , Franke Ralf , Wirker Stefan 
Published: March 2022

Abstract
Auch in den Entwicklungsbüros wird das Medium Internet zunehmend interessant. Nicht nur für Anwendungen wie E-mail und Recherche, sondern auch zur Visualisierung und Verteilung von Produktdaten. Firmenintern oder -übergreifend eingesetzt, bietet sich eine von allen Mitarbeitern handhabbare Kommunikationsplattform. Überall, wo Originaldaten nicht bearbeitet werden müssen, entsteht eine Alternative zu teuren CAD- und PDM-Systemen. Die zur Visualisierung per Internet geeigneten Zeichnungs- und Modellformate lassen sich heute problemlos mit CAD-Systemen erzeugen. Animations- und Betrachtungsfunktionen stehen wie im CAD-System zur Verfügung.
Aktives Projekt-Controlling
Authors: Meyborg Bernd , Sixt Alexander , Gillmeister Frank , Müller-Atzerodt Dirk 
Published: March 2022

Abstract
Großprojekte im Entwicklungsbereich werden zunehmend in Form von überbetrieblichen Netzwerken durchgeführt. Diese Organisationsform erfordert schon in der Planungsphase eine Strukturierung der Projekte in Arbeitspakete und die Definition der Schnittstellen, um nicht zuletzt den Gedanken des Simultaneous Engineering Rechnung zu tragen. Die häufig starke Differenz zwischen Planung/Kalkulation und Durchführung in bezug auf Termin- und Kosteneinhaltung zeigt, daß die Planung, Kontrolle und Steuerung dieser Projekte vielen Unternehmen große Probleme bereiten. Dieser Beitrag beschreibt in verallgemeinerter Form eine aus einem konkreten Projekt heraus entwickelte Methode zur Überwindung dieser Problematik.
LOCAIS DE VENDAS DE BEBIDAS ALCOÓLICA: DIMENSÕES FACILITADORAS PARA O COMPORTAMENTO DE BEBER – O CASO DE COSTA RICA - MS
Authors: Da Silva Maria Romilda , Favieri Giusepe , Romero Marques Heitor 
Published: March 2022

A indústria de bebida alcoólica promoveu transformações na sociedade, porque provocou, por um lado, no âmbito coletivo, a criação de postos de trabalho no mercado, seja ele formal ou informal, o fornecimento e distribuição em diversos locais dos estados brasileiros, desde a metrópole o mais remoto lugar, e até mesmo locais internacionais; e, por outro lado, provocou, no âmbito individual, problemas nas dimensões sociais, física e psíquica, na medida em que o consumidor é afetado pela ingestão do produto alcoólico. No caso da cidade de Costa Rica, situada no estado de Mato Grosso do Sul, observou-se um continuo consumo de bebidas alcoólicas pela sociedade costa-riquense. Verificou-se empiricamente que muitos familiares buscam ajuda psicológica e psiquiátrica para combater o quadro de alcoolismo. Diante desse fato surgiu uma indagação problematizadora: o consumo é facilitado pelas dimensões internas do sujeito ou é pelo fácil acesso? Para responde-la foi elaborado um estudo de campo complementado de um estudo bibliográfico com técnicas quanti-qualitativa para análise dos dados. Para nortear esta pesquisa, foram elaborados os seguintes objetivos, o geral: levantar os locais de vendas de bebidas alcoólicas, e os específicos: caracterizar o local em sua dimensão geográfica; descrever os locais de vendas de bebidas alcoólicas; identificar as dimensões facilitadoras para o consumo de bebidas alcoólicas.
SOCIEDADE EM REDE
Authors: Correa Ana Beatriz , Souto Geórgia , Ortigara Lucas 
Published: March 2022

Um mundo cada vez mais conectado tem seus prós, mas traz à tona também muitos problemas. O cyberbullying é um assédio que ocorre através das redes sociais, e vem afetando cada vez mais os jovens adolescentes. Baseando-se em estudos já realizados e em uma pesquisa acerca do tema junto a 182 jóvens, este artigo traz uma discussão sobre o cyberbullying e seus efeitos psicológicos nas suas vítimas.
Free vibration analysis of multi-layer rectangular plate containing magnetorheological fluid and flexible core layers rested on Winkler-Pasternak foundation
Authors: Shekarzadeh Mehdi , M.M. Najafizadeh  , P. Yousefi  , A. Nezamabadi  , K. Khorshidi  
Published: March 2022

Magneto-rheological (MR) fluids viscosity can be varied by changing the magnetic field intensity. Therefore, they can improve structural rigidity and damping property. The current study presents a free vibration analysis of a multilayer rectangular plate with two layers of MR fluid and a flexible core layer, rested on a Winkler-Pasternak foundation based on exponential shear deformation theory (ESDT). In this theory, the exponential functions are applied in terms of thickness coordinates to include the effect of transverse and inertial rotational shear deformation. The flexible core displacement is modeled via the second-order Frostig model. The Hamilton’s principle is used to derive the equations of motion. These equations are solved using the Navier method to obtain the natural frequencies of the plate. The accuracy of the derived equations is validated, and the obtained results are compared with a specific case. Finally, the results show that by applying and increasing the magnetic field intensity, the natural frequencies and loss factor increase. With the increase in the mode number for each specific magnetic field intensity, the natural frequency increases and the loss factor decreases. The natural frequencies and loss factor decrease with the increase of the MR layer thickness to overall thickness ratio and the flexible core layer thickness to overall thickness ratio. The natural frequencies increase when the parameters of the foundation increase.
A 17-year-old boy with lymphocytic infundibuloneurohypophysitis who developed non-alcoholic steatohepatitis effectively treated with growth hormone
Authors: Takahashi Hidekuni , Nishimata Shigeo , Kumada Atsushi , Yamanaka Gaku , Kashiwagi Yasuyo , Kawashima Hisashi 
Published: March 2022

Summary
We encountered a case of childhood-onset lymphocytic infundibuloneurohypophysitis, based on the MRI and endocrinological findings, with decreased function of the anterior and posterior lobes of the pituitary. Three years after the diagnosis, the patient developed non-alcoholic steatohepatitis (NASH), which was effectively treated by growth hormone (GH) supplementation. The present case demonstrated that NASH can be effectively treated by short-term GH supplementation, even in late childhood.

Learning points

In recent years, the efficacy of growth hormone replacement therapy in normalizing the liver function of adult-onset growth hormone deficiency patients with non-alcoholic steatohepatitis (NASH) has been reported.

Lymphocytic infundibuloneurohypophysitis is a very rare disease, particularly in childhood.

We here presented a rare case of a child with lymphocytic infundibuloneurohypophysitis who developed NASH and showed substantial improvement in liver function after growth hormone treatment.
Bruxism an Issue Between the Myths and Facts
Authors: Cervantes-Chavarría Andrés R. , Utsman Abarca Robert , Herrero Babiloni Alberto 
Published: March 2022

Is our goal in this paper to discuss the current concepts about bruxism, a topic that has been a matter of discussion on the dental field for many years. Recent International efforts have been made to challenge bruxism old definitions; this has derivate to a consensus and an actual new concept that defines bruxism as a behavior instead of a disorder. As a behavior, it is explained in this review how it can have negative health consequences, can be innocuous and how new research support that bruxism can even be a protective factor. Different etiological factors are reviewed in this paper as well the influence of external and internal mechanism related to medications, emotional stress, systemic factors, and potential pharmacological pathways. Moreover, it is briefly summarized the role of oral appliances on sleep bruxism. Finally, clinical considerations and recommendation for the dental professional regarding sings that should be notice during the exam are part of this overview.