bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Flavonoids with Catechol Moiety Inhibit Anticancer Action of
Bortezomib: What about the other Boronic Acid-based Drugs?
Authors: Sak Katrin 
Published: May 2022

Abstract:
Approval of the first boronic acid group-containing drug, bortezomib, in 2003 for the
treatment of multiple myeloma sparked an increased interest of medicinal chemists in boronic acidbased
therapeutics. As a result, another boronic acid moiety-harboring medication, ixazomib, was approved
in 2015 as a second-generation proteasome inhibitor for multiple myeloma; and dutogliptin is
under clinical investigation in combination therapy against myocardial infarction. Moreover, a large
number of novel agents with boronic acid elements in their structure are currently in intensive preclinical
studies, allowing us to suppose that at least some of them will enter clinical trials in the near future.
On the other hand, only some years after bortezomib approval, direct interactions between its boronic
acid group and catechol moiety of green tea catechins as well as some other common dietary
flavonoids like quercetin and myricetin were discovered, leading to the formation of stable cyclic
boronate esters and abolishing the anticancer activities. Although highly relevant, to date, no reports
on possible co-effects of catechol group-containing flavonoids with new-generation boronic acidbased
drugs can be found. However, this issue cannot be ignored, especially considering the abundance
of catechol moiety-harboring flavonoids in both plant-derived food items as well as over-thecounter
dietary supplements and herbal products. Therefore, in parallel with the intensified development
of boronic acid-based drugs, their possible interactions with catechol groups of plant-derived
flavonoids must also be clarified to provide dietary recommendations to patients for maximizing therapeutic
benefits. If concurrently consumed flavonoids can indeed antagonize drug efficacy, it may
pose a real risk to clinical outcomes.
Antibiotics’ Sustainability: Another Issue in the Fight against Antimicrobial
Resistance
Authors: Buroni Silvia , Chiarelli Laurent R. 
Published: May 2022

Abstract:
The spread of antimicrobial resistance (AMR) is still a major threat to global health that is likely to worsen also as a consequence of the COVID-19 pandemic. For this reason, there is an urgent need to develop new compounds and novel alternative treatments. Furthermore, the new lines of action must consider the issue of antibiotics’ sustainability. Within this persrective, we have highlighted the main points on which actions in this perspective are possible.
An Efficient Synthesis, Characterization, and Antimicrobial Activities of
Organomercury (II) piperidine-N-thiohydrazide Complexes
Authors: Sharma Rama 
Published: May 2022

Aim:
To synthesize and characterize organomercury complexes.

Background:
Organomercury complexes have reported for different antimicrobial activities.

Objectives:
Synthesis of organomercury complexes with piperidine thiohydrazide ligand and characterization,
applications.

Methods:
Complexes were synthesized by modified reported methods. Spectral (IR, UV, 1HNMR) and
TG/DTA analyses were used to characterize the generated complexes. For some of the complexes produced,
chemical kinetic characteristics such as activation energy, order of reaction, heat of reaction,
and apparent activation entropy were determined. The antimicrobial activities were also reported.

Results:
In these synthesized complexes, the thiohydrazides act as bidentate ligands, coordinating
through the thiol Sulphur and terminal nitrogen. Elemental and spectral data of the ligand and complexes
show that the compounds are pure enough.

Conclusion:
Every synthesized complex is diamagnetic in nature. The complexes have better antibacterial
activities against Z. mobilis than E. coli, with A. niger > Cerveleria in case of antifungal activities.
Efficient One-pot Synthesis of Pyrano[2,3-d]pyrimidinone Derivatives
Catalyzed by a Novel and Recyclable CuO/NiO Nanocatalyst
Authors: Beni Zohreh Hashemi , Albadi Jalal , Kiyani Hamzeh , Shalamzari Heshmat Allah Samimi 
Published: May 2022

Background:
In this study, the synthesis and characterization of a novel kind of NiO-supported
CuO nanoparticles (CuO/NiO nanocatalyst), as an efficient and recyclable catalyst, were carried out.

Methods:
Nanocatalyst was characterized by XRD, BET, FESEM, EDS, HRTEM, TGA and DSC
analysis. It was used in the three-component synthesis reaction between barbituric acid, malononitrile
and various aromatic aldehydes for the synthesis of pyrano[2,3-d]pyrimidinone derivatives.

Results:
The advantages of using CuO/NiO nanocatalyst in this reaction are high yields of products,
a decrease in the reaction times and easy separation of catalyst from the reaction mixture, and the
reaction being performed in one-pot.

Conclusion:
The CuO/NiO nanocatalyst can be recycled for five consecutive cycles without significant
degradation in its catalytic activity.
Diabetes Mellitus Type 1 During COVID-19: Psychological Symptoms and
Eating Attitudes
Authors: Benioudakis Emmanouil S. , Karlafti Eleni , Georgiou Evangelos D. , Kalaitzaki Argyroula , Kaiafa Georgia , Savopoulos Christos , Didangelos Triantafyllos 
Published: May 2022

Background:
Diabetes Mellitus Type 1 is a chronic metabolic disorder, the treatment of
which extremely burdens the patient. The lockdown, as a measure to prevent the spreading of the
2019 coronavirus disease, was a major challenge for the general public. People with chronic diseases,
such as T1D patients, have complex emotional and psychological needs and are at increased
risk for both depressive symptoms and anxiety.

Objective:
The aim of this study was to evaluate the impact of body mass index of T1D patients on
the psychological symptoms and eating habits, as well as the prognostic factors of the psychological
symptoms during the lockdown period.

Method:
Diabetes mellitus patients were invited to complete this survey from the outpatient Diabetes
clinic of the General Hospital of Chania and the “AHEPA” General University Hospital of
Thessaloniki in Greece. Psychological symptoms were assessed using the DASS-42 questionnaire,
and eating habits were assessed using the EAT-26 questionnaire.

Results:
Overall, 112 T1D patients were analyzed (response rate: 28.8%). Obese T1D patients appear
to be at greater risk of developing psychological symptoms, such as depression, anxiety, and
stress. Furthermore, disordered eating behaviors and bulimia and food preoccupation subscale are
associated with psychological symptoms.

Conlcusion:
The findings suggest that obese T1D patients are at greater risk of developing psychological
symptoms. Moreover, when an eating disorder is triggered, negative psychological symptoms
such as depression and anxiety are reduced. The results of this study may guide targeted interventions
among T1D patients
Nutritional Knowledge, Practices and Challenges of Food and Nutrition
Security in the Tharparkar, Sindh, Pakistan
Authors: Lanjwani Abdul Hameed , Shah Qararo , Shaikh Ghulam Serwar , Lanjwani Muhammad Farooque , Jesrani Vinay Kumar , Kapoor Aneel 
Published: May 2022

Background:
Nutrition is a fundamental need of human beings worldwide. Hunger
has increased rapidly all over the world and reached a high level with more than one billion people
living with chronic hunger.

Objective:
The main objective of the proposed study was to identify the challenges of food and
nutrition insecurity.

Methods:
The research team conducted interviews in the respective union councils (UCs)
with support of the field team, and subsequently collected and analyzed the data.

Results and Discussion:
The findings of the present study indicated that 32% of households
gave their children food/fluids within one month, followed by breastfeeding. About 81% breastfeeding
practice is strictly followed at the household level. Only 23%, 22%, 27% and 28% of
children with the ages between 6 and 23 months were given one, two, three and four meals, respectively.
The data indicates that about 11% of children faced issues during their feeding practices,
while 89% of children did not face any feeding issues. The majority of pregnant and lactating
women (PLWs) reported that they did not receive any additional food. The consumption of
fresh vegetables and fruits was around 30% twice in a week. The vegetables and fruits, including
watermelon, jujube, peroon, singari, pipoon, musk melon, keria and gangheti, were cultivated,
which are solely dependent on the seasonal rain. The diseases, such as respiratory diseases, skin
diseases, cardiac disease, malaria, dengue and mental illness, were reported; whereas, measles
and night blindness were not reported in the selected area.

Conclusion:
There is a need of spreading the message through media at the district and province
levels with the involvement of multi-stakeholders, so that the efforts are synergized to have a
sustainable and long-term impact.
A Bird’s Eye View on Evaluation of Anti-Plasmodial Efficacy of Natural
Products Isolated from Marine Sources
Authors: Bhowmik Subhendu , Sivamurugan Vajiravelu , Dhanalakshmi Ravi Kumar , Dharani Venkatesan , Ravichandiran Valayutham 
Published: May 2022

Abstract:
Malaria is one of the deadliest vector spreading diseases which causes enormous health concern in the tropical world, especially in sub-Saharan countries. Despite tremendous efforts around the globe, malaria is one of the leading causes of death in those areas. In addition, the appearance of resistance to the currently available drugs are making the situation more alarming, which highlights the urgency for continued research to stay prepared and evaluation of natural products could be the best approach in this direction. In drug discovery, nature plays an important role as most of the currently marketed drugs are either modified or nonmodified or synthetic compounds with a natural product as a pharmacophore. Even in the case of antimalarial drugs, starting from the discovery of quinine to the currently utilized artemisinin, most of the effective antimalarial drugs are derived from terrestrial natural sources. However, although the ocean constitutes almost 75% of the Earth, the exploration and discovery of antimalarial drugs from marine sources are very limited. This comprehensive review assimilates anti-malarial natural products derived from marine sources in recent times. In particular, the natural products from oceanic microorganisms and their plants are considered as sources for the review.
Long-term CR Multiple Myeloma Patients Show Cured or MGUS-like
Minimal Residual Disease Pattern by Next Generation Flow
Authors: Gozzetti Alessandro , Pacelli Paola , Raspadori Donatella , Bestoso Elena , Tocci Dania , Sicuranza Anna , Bocchia Monica 
Published: May 2022

Background:
In the era of novel agents, many multiple myeloma patients can achieve a complete remission, but most of them relapse, and minimal residual disease detection can play a crucial role. Next-generation flow (NGF) can detect monoclonal plasma cells with a sensitivity of 10-6. Little is known about long-term remission patients (> 2 years) and in particular, if more sensitive techniques such as NGF can still detect minimal disease in those patients.

Objective:
Aim of the study was to analyze patients with MM in response to NGF at > 2 years of sustained remission after several treatments.

Method:
MRD was studied by NGF in bone marrow aspirates according to Euroflow Consortium indi-cations.

Results:
62 patients with sustained CR at >2 years were studied, MRD+ status was detected at a thresh-old cut-off of 10-6 in 32/62 (52%); 4/15 (27%) patients were MRD positive at >5 years of remission and they displayed a prevalence of normal vs abnormal monoclonal plasma cell immune-phenotype (MGUS-like).

Conclusion:
NGF is a powerful technique to detect MRD. Myeloma patients in prolonged sustained complete remission can show in high percentage an MRD negative status or MGUS like.
Hubungan Pengetahuan Dengan Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Dan Faktor Yang Mempengaruhinya
Authors: Yuliawati Agustina Nila , Ratnasari Pande Made Desy , Rosalina Putri Riski 
Published: May 2022

Knowledge is important to control blood sugar and prevent complications and subsequently have an impact on the quality of life (QOL) of type 2 diabetes mellitus (T2DM) patients as a response to their health. This study aimed to determine the correlation between level of knowledge and QOL in type 2 DM (T2DM) patients, also its related factors. This cross-sectional study was conducted in a Public Hospitals, Buleleng, Bali on September 2020. Inclusion criteria included T2DM outpatients who ≥aged 18 years, get similar therapy for at least 3 months, filling out the questionnaire completely, able to communicate well, and not in a pregnant/breastfeeding condition. Data were obtained by medical records, questionnaires DKQ-24 (knowledge) and EQ-5D-5L (QOL). Correlation between knowledge and QOL of T2DM patients and its related factors were analyzed using bivariate statistical tests. Finding of 150 respondents demonstrated mostly were ≥60 years old (53.3%), female (50.7%), first educational level (64%), not working (54%), low income (49.3%), >5 years of T2DM duration (44%), no complications (75.3%), taking 4-6 item medicines (66.7%), moderate knowledge level (70.7%) with QOL based on the utility score was 0.892±0.154 and VAS was 59.73±20.07. Statistical tests showed there was a significant correlation between knowledge and QOL based on utility value (p=0.01), but not with VAS value (p=0.165). These was reinforced by age has a significant correlation with knowledge (p=0.042), also employment status and complications condition has a significant correlation with QOL (p<0.05). Patients with a higher level of knowledge have a better QOL, despite different backgrounds.
Cambios institucionales durante las crisis financieras: lecciones para América Latina
Authors: Correa Eugenia 
Published: May 2022

<p>El pensamiento dominante parece apoyar la idea de que una vez que una crisis financiera <em>termina</em> todo regresa a la normalidad. Si acaso serían necesarios algunos cambios regulatorios sobre el capital y las reservas de los bancos. Sin embargo, para entender lo que realmente ocurre durante las crisis financieras y los cambios que generan en la actividad económica en general, es esencial un enfoque teórico post-keynesiano institucionalista. Este trabajo discute cómo muchos de los cambios en las relaciones de financiamiento, provocados por crisis financieras desde los años ochenta, han abierto el camino al <em>money manager capitalism</em>. La diversidad política e institucional en América Latina permite observar no solo la trayectoria del cambio sino también sus formas. Estos países han tomado decisiones distintas en lo que se refiere a la estabilización económica y la regulación financiera, con resultados moderadamente distintos sobre la distribución del ingreso, los salarios y el empleo. A su vez, las dificultades generalizadas para frenar o abolir las políticas de austeridad muestran la profundidad de los cambios institucionales que restringen las políticas monetarias y fiscales en el contexto de financiarización. Se concluye que las crisis financieras han cambiado los fundamentos de la organización social.</p><div><div><p> </p></div><div><p> </p></div></div>
Políticas fiscales y crisis financiera mundial. Comprendiendo la experiencia de los tres mayores países latinoamericanos.
Authors: Correa Eugenia 
Published: May 2022

Las políticas fiscales de los países de América Latina han evolucionado dentro de panoramas institucionales muy diferentes, resultado de una larga historia de crisis financieras. Este artículo analiza varias de las transformaciones económicas e institucionales de las tres mayores economías de América Latina, a saber, Argentina, Brasil y México, y su evolución durante los últimos veinte años, con el fin de comprender la capacidad de aplicar políticas fiscales contracíclicas durante la gran crisis mundial. Se discute la idea de que las economías de mercado abiertas y emergentes no poseen condiciones para ejercer una política fiscal anticíclica. La principal conclusión es que sólo Argentina ha sido capaz de ejercer plenamente su capacidad de política fiscal durante la crisis, mientras que siguen existiendo limitaciones institucionales en las políticas fiscales de Brasil y México.<br /><div><div><p> </p></div></div>
Impacto de la privatización de la seguridad social en el presupuesto. Mujeres: doblemente desprotegidas
Authors: Correa Eugenia 
Published: May 2022

Durante la década de 1990, muchas economías en desarrollo instauraron reformas financieras fundamentales para modificar los sistemas de pensiones. Este artículo hace un análisis de los principales resultados de estas reformas desde la perspectiva de género. A pesar de ser vistas como reformas sociales, las reformas a los sistemas de pensiones han incrementado la parte de la población que no cuenta con seguridad social, por otra parte, las mujeres, al tener una mayor esperanza de vida, se encuentran en una situación de precariedad laboral relativamente mayor. El artículo también se centra en las implicaciones fiscales y, particularmente, en la transición del sistema de pensiones de reparto que era autofinanciado y sostenible a un sistema cuyas contribuciones van a fondos de pensiones privados, lo que crea una brecha de financiamiento que, en muchos de los sistemas de pensiones actuales, está solventándose con los presupuestos públicos. Vista como una reforma financiera, este cambio ha tenido también resultados interesantes, pues, a pesar de que el sistema privado no incrementa la cobertura ni cumple con los flujos de capital proyectados, sí produce un flujo constante de ahorro obligatorio y acumulado que brinda liquidez a los mercados financieros nacionales, e incluso, internacionales. Sin embargo, esta liquidez no ha sido un factor en el incremento de los flujos de crédito del sector privado nacional no financiero. Bajo las condiciones de las políticas de austeridad, los cortes presupuestarios en otros ámbitos del gasto público, como la educación y, en especial, la atención médica, dejan a las mujeres doblemente desprotegidas.<br /><div><div><p> </p></div></div>
Nuria Sánchez Madrid, <i>Elogio de la razón mundana. Antropología y política en Kant</i>
Authors: González Fisac Jesús 
Published: May 2022

Reseña del libro de Nuria Sánchez Madrid, Elogio de la razón mundana. Antropología y política en Kant, Ediciones La Cebra, Buenos Aires, 2018, 299 pp.
SISTEMATIZAÇÃO E ESTRUTURAÇÃO DE UM SISTEMA DE INOVAÇÃO PARA SUPORTE À CRIAÇÃO DE NOVOS PRODUTOS ELETRÔNICOS
Authors: Souza Júlia Viana de , Brito Kaylane de Cassia Vasconcelos de , Oliveira Luiz 
Published: May 2022

O projeto vem sistematizando e estruturando metodologias e práticas de inovação em produtos eletrônicos baseando-se em conceitos da Cultura Maker e do método PDP (Processo de Desenvolvimento de Produto) com o afã de motivar e preparar jovens inventores a realizarem suas ideias, muitas vezes inovadoras. Assim, por sistematizar intenciona-se a organização de uma cartilha contendo as principais disciplinas relevantes à criação de produtos, no contexto da Economia 4.0, para efeito das melhores práticas serem catalogadas e organizadas de forma didática, além de replicadas por outros interessados. Enquanto, estruturar evidencia o objetivo de aparelhamento do Laboratório de Robótica e Fabricação Digital com os insumos necessários a criação de um acervo de componentes eletrônicos genéricos capazes de assistir os inventores no processo de criação de novos produtos, incentivando assim o desenvolvimento da economia local. Todavia, as iniciativas do grupo consistem, a todo o momento, em proporcionar a comunidade externa e acadêmica o máximo possível de conhecimento e experiências no que tange às práticas de prototipação eletrônica, criação e desenvolvimento de um novo produto eletrônico. Assim, uma das novas propostas busca cultivar as habilidades interpessoais, muito necessárias ao processo criativo.
Razor's Edge: Robert Lowell Shaving
Authors: Austenfeld Thomas 
Published: May 2022

ABSTRACTPoetic evocations of bathrooms and especially of the act of shaving allowed Robert Lowell to explore certain manifestations of his manic-depressive illness in daily life. Particularly prominent in Life Studies but present throughout Lowell's work, references to shaving are linked to psychological turmoil, while bathrooms are explored as heterotopic spaces (Foucault). Confessional poetry finds a hitherto unexamined field in this poetic work.
A Soldier and His Suitcase: Karl Rossmann's Arrival in and Deliverance from Kafka's Amerika
Authors: Hammond, Charles H. 
Published: May 2022

ABSTRACT
The metaphor of the suitcase and the motif of the soldier play critical, mutually reinforcing roles in Franz Kafka's first novel fragment Der Verschollene. The suitcase that the protagonist receives from his father as he departs for America represents the father's legacy. Similarly, the motif of the soldier symbolizes idealized masculinity. These two elements intersect when Karl reveals that his suitcase is the same one his father brought with him when he joined the military. Ultimately, Karl is both unable to maintain possession of the suitcase and to realize his initial dream of becoming a soldier.
“Unerhörte Begebenheiten” in Karl Philipp Moritz's “Journal of Empirical Psychology (1783-1793)”
Authors: Dickson Sheila 
Published: May 2022

ABSTRACTThe German periodical Magazin zur Erfalnungsseelenkunde (1783-93) presents ten volumes of short essays submitted by educated lay people describing aspects of the mind from an Enlightenment perspective, with a strong focus on aberrant psychology. The contributions are interpreted as a hybrid form of psychological case histories and short stories which, in Goethe's contemporary definition, describe "sich ereignete unerhörte Begebenheiten" [extraordinary but true events]. This form lent itself well to debate on the parameters of sanity and madness, in particular, how far madness lay beyond apprehension by the sane and to what extent any boundaries between the two could meaningfully be drawn.
Problematika Siswa dalam Pembelajaran Daring dengan Menggunakan Aplikasi Google Meet
Authors: Putri Risma Septia Hanayya , Amaliyah Nurrohmatul , Pranata Khavisa 
Published: May 2022

Banyak kendala yang dihadapi guru dan siswa selama pembelajaran jarak jauh. Sehingga menyebabkan pembelajaran kurang maksimal. Guru berupaya agar pelaksanaan pembelajaran dapat berjalan dengan efektif melalui penerapan aplikasi Google Meet. Penelitian ini bertujuan untuk menganalisis problematika siswa dalam pembelajaran daring menggunakan aplikasi Google Meet Kelas IV SD. Penelitian ini menggunakan metode kualitatif deskriptif dengan jenis pendekatan studi kasus. Teknik pengumpulan data dalam penelitian ini dilakukan dengan triangulasi data yang mencakup observasi, wawancara dan juga dokumentasi. Hasil penelitian menunjukkan bahwa pembelajaran secara daring di kelas IV hanya sebagian siswa yang mengikuti Google Meet. Problematika pembelajaran daring kelas IV SD yaitu masalah kompetensi guru. orang tua yang tidak memiliki gadget. Adapun faktor pendukung dalam pelaksanaan pembelajaran secara daring ini ialah lebih mudah mendapatkan informasi tambahan mengenai materi pembelajaran, faktor penghambat pembelajaran secara daring yakni kurang memadainya sarana pembelajaran pada beberapa siswa, serta kesulitan dalam menentukan apakah siswa benar-benar memahami materi pembelajaran atau tidak. Implikasi penelitian ini diharapkan dapat menjadi bahan evaluasi bagi sekolah dalam meningkatkan pelaksanaan pembelajaran daring menjadi lebih optimal.