bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies
Authors: Rodriguez-Cruces Raul , Royer Jessica , Larivière Sara , Bassett Dani S. , Caciagli Lorenzo , Bernhardt Boris C. 
Published: February 2022

Abstract
Epilepsy is one of the most common chronic neurological conditions, traditionally defined as a disorder of recurrent seizures. Cognitive and affective dysfunction are increasingly recognized as core disease dimensions and can affect patient well-being, sometimes more than the seizures themselves. Connectome-based approaches hold immense promise for revealing mechanisms that contribute to dysfunction and to identify biomarkers. Our review discusses emerging multimodal neuroimaging and connectomics studies that highlight network substrates of cognitive/affective dysfunction in the common epilepsies. We first discuss work in drug-resistant epilepsy syndromes, that is, temporal lobe epilepsy, related to mesiotemporal sclerosis (TLE), and extratemporal epilepsy (ETE), related to malformations of cortical development. While these are traditionally conceptualized as ‘focal’ epilepsies, many patients present with broad structural and functional anomalies. Moreover, the extent of distributed changes contributes to difficulties in multiple cognitive domains as well as affective-behavioral challenges. We also review work in idiopathic generalized epilepsy (IGE), a subset of generalized epilepsy syndromes that involve subcortico-cortical circuits. Overall, neuroimaging and network neuroscience studies point to both shared and syndrome-specific connectome signatures of dysfunction across TLE, ETE, and IGE. Lastly, we point to current gaps in the literature and formulate recommendations for future research.
Kilka uwag o ekwiwalencji międzyjęzykowej: na przykładzie konfrontacji polskiej i ukraińskiej frazeologii
Authors: Tymoshuk Roman 
Published: February 2022

Some Remarks on Interlingual Equivalence: Based on the Contrastive Analysis of Polish and Ukrainian PhraseologyThe article focuses on the problem of interlingual equivalence in the context of Polish and Ukrainian contemporary phraseology. The author provides examples of the use of parallel corpora in research on equivalence and outlines the concept of presenting the adequacy of phraseological units in the Leksykon aktywnej frazeologii polskiej i ukraińskiej [Dictionary of Active Polish and Ukrainian Phraseology]. The aim of the study is to draw attention to the importance of creating a new type of bilingual dictionaries, presenting the current state of phraseological resources, and the use of digital tools in contrastive analysis. Kilka uwag o ekwiwalencji międzyjęzykowej: na przykładzie konfrontacji polskiej i ukraińskiej frazeologiiW artykule skoncentrowano się na problemie ekwiwalencji międzyjęzykowej w oparciu o materiał współczesnej frazeologii polskiej i ukraińskiej. Przedstawiono przykłady wykorzystania korpusów równoległych w badaniach nad ekwiwalencją oraz koncepcję prezentacji odpowiedniości jednostek frazeologicznych w Leksykonie aktywnej frazeologii polskiej i ukraińskiej. Celem niniejszego tekstu jest zwrócenie uwagi na istotność tworzenia nowego typu słowników dwujęzycznych, prezentujących aktualny stan zasobów frazeologicznych oraz wykorzystania narzędzi cyfrowych w konfrontacji językowej.
Pomiędzy autobiografią a mitem. Opowiadania Oty Pavla na tle twórczości pisarzy polsko-żydowskich
Authors: Budzyńska Alicja 
Published: February 2022

Between Autobiography and Myth: Short Stories by Ota Pavel Against the Background of Works of Polish-Jewish WritersThis article is a comparative overview of short stories by Ota Pavel from his collections Smrt krásných srnců [The Death of the Beautiful Roebucks] and Jak jsem potkal ryby (How I Came to Know Fish). The background for Pavel’s prose are texts written by Bruno Schulz and Artur Sandauer. The aim of this comparison is to capture some universal themes of those works, including writing strategies, which transform classical autobiographical conventions. Pomiędzy autobiografią a mitem. Opowiadania Oty Pavla na tle twórczości pisarzy polsko-żydowskichPraca jest komparatystycznym spojrzeniem na opowiadania Oty Pavla z tomów Śmierć pięknych saren i Jak spotkałem się z rybami. Tłem dla prozy czeskiego pisarza jest twórczość Brunona Schulza i Artura Sandauera. Porównanie to ma na celu uchwycenie pewnych uniwersalnych elementów łączących ich dzieła. Uniwersalność ta widoczna jest w wykorzystywanych strategiach pisarskich, przetwarzających konwencję klasycznej autobiografii.
Redefining Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma
Authors: Cohen Erin R. , Misztal Carly , Dable Cortney , Gomez‐Fernandez Carmen , Bhatia Rita G. , Roth Patrick , Ma Ruixuan , Trosman Samuel , Green Carlos , Nicolli Elizabeth , Dinh Christine T. , Sargi Zoukaa B. 
Published: February 2022

ObjectivePerineural invasion (PNI) negatively affects disease‐specific survival in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC). We aim to analyze the prognostic implications of PNI‐related features.Study DesignRetrospective cohort study.SettingAcademic tertiary care hospital.MethodsRetrospective chart review was performed on 104 patients diagnosed with HNcSCC between January 2011 and October 2019 who underwent resection, parotidectomy, and neck dissection with more than 1 year of follow‐up. PNI was classified as incidental (identified on histopathology alone) or clinical (present on radiography and/or physical exam). Primary outcome measures were overall survival and disease‐free survival (DFS). Kaplan‐Meier analysis, logistic regression, and Cox regression were performed.ResultsThe overall 5‐year DFS was 57.9%. Sixty‐one patients had PNI. On histopathology, 28 lesions showed complete nerve encirclement, 10 involved >5 nerves, and 12 involved named nerves. Patients with facial weakness (P =. 026) and positive margins (P =. 0029) had a higher likelihood of histopathologic PNI, and positive margins retained significance on multivariable analysis (P =. 0079). Worse DFS was seen in patients with PNI (P =. 004), advanced tumor stage (P =. 049), positive margins (P =. 014), and >5 nerves involved (P =. 0061). Furthermore, histopathologic PNI was a predictor of DFS (hazard ratio [HR], 3.07; 95% CI, 0.33‐1.38; P =. 0061) overall and in the clinical PNI cohort (HR, 3.43; 95% CI, 1.65‐7.10; P =. 00091).ConclusionDFS was significantly worse in patients with PNI, facial nerve weakness, advanced T stage, positive margins, and multiple nerve involvement. Further characterization of PNI features may help improve prognostic predictions and identify patients who may benefit from more aggressive treatment.
Examination of Sex Differences in a Chronic Rhinosinusitis Surgical Cohort
Authors: Ramos Laylaa , Massey Conner J. , Asokan Annapoorani , Rice John D. , Kroehl Miranda , Ramakrishnan Vijay R. 
Published: February 2022

ObjectiveSex discrepancies have been reported in chronic rhinosinusitis (CRS), but limited data exist exploring sex‐specific biological processes and sinonasal quality of life.Study DesignProspective cohort.SettingAcademic medical center.MethodsDemographics, clinical data, and sinonasal mucus were collected from patients with CRS presenting for surgical consideration over a 5‐year period. A random forest model and linear regression were used to assess predictor variables for the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) and subdomains. Enzyme‐linked immunosorbent assays were used to measure substance P and tryptase in a subset of mucus samples to explore biological differences by sex.ResultsIn total, 520 patients were studied (mean age 48.3 years, 50.9% female). Males were older (50.1 vs 46.6 years, P =. 008), had more polyp disease (48.2% vs 35.5%, P =. 004), and had higher mean Lund‐Mackay CT score (11.3 vs 9.5, P =. 004). Females had a higher overall mean SNOT‐22 (40.9 vs 46.9, P =. 001) and higher scores in ear/facial, psychological, and sleep domains (P <. 01). Age, objective disease measures, and sex were top predictors for total SNOT‐22. Neither mucus substance P or tryptase, alone or paired with sex, correlated with total SNOT‐22. Analysis of mucus biomarkers by sex revealed correlation between mucus tryptase in females with the extranasal subdomain (P =. 01).ConclusionSex differences exist in CRS disease manifestations and presentation for surgical consideration. Detection of mucus (substance P and tryptase) was reliable, but in this exploratory study, we were not able to establish neurogenic or allergic inflammatory processes as a large source of differential disease features between sexes.
Reliability of different body temperature measurement sites during normothermic cardiac surgery
Authors: Sastre José A , López Teresa , Moreno-Rodríguez Maria A , Reta-Ajo Leyre , Rubia-Martín María C , Díez-Castro Rosa 
Published: February 2022

Introduction Patients undergoing cardiac surgery can experience significant thermal changes during the perioperative period and, for that reason, it is essential to monitor temperatures with adequate accuracy and precision during cardiopulmonary bypass (CPB). The primary aim of the current study was to measure the discrepancies between temperatures at different body sites during normothermic or mild hypothermic CPB. Methods 48 patients undergoing cardiac surgery participated in our study. Simultaneous temperatures were measured at nasopharynx, pulmonary artery, arterial outlet, venous inlet, forehead using a heat flux sensor, and urinary bladder at 5-min intervals throughout surgery. The Bland-Altman plot for repeated measures was used to assess concordance between methods. Results The duration of surgery was 360 min (interquartile range (IQR) 300–412), while the median cross-clamp time was 135 min (IQR 101–169). During the CPB time, the average difference between arterial outlet and nasopharyngeal temperature was −0.16°C (95% limits of agreement of ±0.93). The bias between arterial outlet and the venous inflow was 0.16°C and the 95% limits of agreement were −0.63 to 0.95°C. The Bland-Altman analysis showed an average difference between oxigenator arterial outlet and bladder probe of −0.62 (95% limits of agreement of ±1.3). The average difference between arterial outlet and Tcore™ temperatures was 0.08°C (95% limits of agreement of ±1.46). 25 patients (52.08%) presented nasopharyngeal temperatures higher than 37°C in the post-CPB period, but none of them exceeded 38°C. Conclusions Perfusionists should be cautious when using the nasopharyngeal site as the only surrogate of brain temperature, even in normothermic cardiac surgery because the precision of measurements is not entirely adequate.
To Compare the Stress Magnitude on Roots of Mandibular Incisors at Different Inclinations With Different Arch Wires During Intrusion Mechanics—A Fem Study
Authors: Rashid Munaza , Singla Anil , Mahajan Vivek , Jaj Harupinder Singh , Dhiman Indu , Thakur Shikha 
Published: February 2022

Introduction: Force is applied through brackets in fixed mechanotherapy which generates stress in periodontal ligament and root of the teeth and is difficult to measure directly. Finite element analysis is used as a solution for understanding this biomechanical response. So the aims and objectives of this study were to evaluate the stress magnitude induced in the labial and lingual surface of mandibular incisors using superelastic NiTi arch wires of different cross-section at different inclination through finite element analysis. Materials and Methods: Finite element model of all mandibular teeth including periodontal ligament, alveolar bone, buccal tubes, brackets, and arch wire were constructed using mechanical elastic properties of the materials. Three different NiTi arch wires, round (0.016″), square (0.016″ × 0.016″), and rectangular (0.016″ × 0.022″), were placed into the bracket slots and models were constructed which were analyzed for stress distribution on root surface and periodontal ligament with 3 different cross-sections at 90°, 100°, and 110° with Ansys Version 14 software. Conclusion: Labial stress was found highest in round arch wire as compared to square and rectangular wire. Lingual stress was found to be slightly more in rectangular wire as compared to round and square arch wire.
Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) 3D printed scaffold cultivated with mesenchymal stem cells directed to bone reconstruction: In vitro and in vivo studies
Authors: Asami Jessica , Hausen Moema A. , Komatsu Daniel , Ferreira Lucas M. , Silva Guilherme B. G. , da Silva Lucas C. S. C. , Baldo Denicezar A. , Oliveira Junior José M. , Motta Adriana C. , Duek Eliana A. R. 
Published: February 2022

A recent and quite promising technique for bone tissue engineering is the 3D printing, peculiarly regarding the production of high-quality scaffolds. The 3D printed scaffold strictly provides suitable characteristics for living cells, in order to induce treatment, reconstruction and substitution of injured tissue. The purpose of this work was to evaluate the behavior of the 3D scaffold based on Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) (PLDLA-TMC), which was designed in Solidworks™ software, projected in 3D Slicer™, 3D printed in filament extrusion, cultured with mesenchymal stem cells (MSCs) and tested in vitro and in vivo models. For in vitro study, the MSCs were seeded in a PLDLA-TMC 3D scaffold with 600 μm pore size and submitted to proliferation and osteogenic differentiation. The in vivo assays implanted the PLDLA-TMC scaffolds with or without MSCs in the calvaria of Wistar rats submitted to 8 mm cranial bone defect, in periods of 8–12 weeks. The results showed that PLDLA-TMC 3D scaffolds favored adherence and cell growth, and suggests an osteoinductive activity, which means that the material itself augmented cellular differentiation. The implanted PLDLA-TMC containing MSCs, showed better results after 12 weeks prior grafting, due the absence of inflammatory processes, enlarged regeneration of bone tissue and facilitated angiogenesis. Notwithstanding, the 3D PLDLA-TMC itself implanted enriched tissue repair; the addition of cells known to upregulate tissue healing reinforce the perspectives for the PLDLA-TMC applications in the field of bone tissue engineering in clinical trials.
Comparison between the ‘pull technique’ and open surgery for peritoneal catheter removal in Chinese patients on peritoneal dialysis
Authors: Dai Yunxin , Guo Hancheng , Li Tingmin , Yao Chunmeng , Xie Zugang , Wang Fuzhen , Yao Cuiwei , Guan Tianjun 
Published: February 2022

Background: The removal techniques for peritoneal dialysis (PD) catheters are open surgical dissection (OD) and the ‘pull technique’ (PT). The latter is limitedly used because of uncertainty about its feasibility and safety. This study aimed to compare the outcomes and complications between the two techniques. Methods: This retrospective study included patients who underwent PD catheter removal from January 2015 to January 2021 in four PD centres in China. The patients were grouped according to the different removal techniques and were followed up to observe the potential complications. Results: The demographic characteristics of patients in the PT ( n = 68) and OD ( n = 44) groups showed no significant difference. The indications for PD catheter removal were similar between the two groups, except for a higher frequency of peritonitis in the OD group ( p = 0.010). In the PT group, the main complications were broken catheter (7.4%), superficial cuff infection (4.8%) and subcutaneous bleeding (4.8%). In the OD group, the main complications were death (9.1%) and subcutaneous bleeding (4.6%). Conclusion: PT might be a safe and reliable technique for PD catheter removal compared to OD. Considering its simple and non-invasive nature, PT should be recommended as the alternative to OD in suitable PD patients.
Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress
Authors: Zhang Pei , Zhang Jiale , Quan Huahong , Chen Pengtao , Wang Jingcheng , Liang Yuan 
Published: February 2022

Purpose Osteosarcoma (OS) is a primary malignant bone tumor, and the cure rate has stagnated in the past three decades. Butein, a plant polyphenol extracted from many herbs, has been proved to possess anti-tumor activity. However, the effect of butein on human OS and the underlying mechanisms remain to be elucidated. Materials and Methods The OS cell line 143B was used. The effects of butein were evaluated through the cell proliferation assay, flow cytometry, florescence and transmission electron microscopy, and western blotting. All statistical analyses were performed using GraphPad Prism 7.0. Results Butein was found to inhibit cell proliferation by causing G2/ M phase arrest in the 143B cells. In addition, butein suppressed the invasion of 143B cells upon IL‐6 treatment. Additionally, we found that butein inhibited the invasion of 143B cells stimulated with IL-6 via the p-STAT3-MMP9 signaling pathway. Remarkably, butein triggered extrinsic and intrinsic apoptosis and autophagy of 143B cells. The process of autophagy may have tumor-supporting effects. Furthermore, butein induced oxidative stress as evidenced by ROS generation, increase in malondialdehyde (MDA) level, and decrease in GSH/GSSH ratio and GPX4 expression. N-acetylcysteine can reverse the change of ROS. Further experiments indicated apoptosis and autophagy could be attenuated by the N-acetyl-L-cysteine and c-Jun N-terminal kinase (JNK) inhibitor SP600125. Additionally, butein inhibited the Akt/mammalian target of rapamycin (mTOR) signaling pathway, and suppressed the Akt kinase activity increased apoptosis and autophagy. Conclusion Our results revealed butein induced apoptosis and autophagy by regulating oxidative stress, activating the JNK signaling pathway and blocking the Akt/mTOR signaling pathway in OS cells. Additionally, butein inhibited the invasion of 143B cells stimulated with IL-6 through the pSTAT3- MMP9 signaling pathway. In view of these results, butein may be a potential anti-tumor drug targeting osteosarcoma.
Intravitreal Injections during the COVID-19 Outbreak in Northern Italy: An Innovative Approach for a High Quality and Safe Treatment
Authors: Scarpa Giuseppe , Urban Francesca , Scarpa Margherita , Formentini Stefano , Beccastrini Andrea 
Published: February 2022

Background Intravitreal injection (IVI) is a standard procedure performed in ophthalmology to treat several conditions, and is performed in different settings across countries. The Italian guidelines recommend this intervention is performed in an operating room to minimize the risk of infections, while in other countries, including Canada, USA and the UK, IVIs are performed in the ophthalmologist's office. The 2020 COVID-19 outbreak caused a dramatic modification in outpatient care. Consequently, non-urgent surgical activities, like IVIs, were subjected to a drastic reduction. Methods We conducted observational study which investigated the outcomes of IVIs performed in an ophthalmologist's office using a mobile laminar flow unit, the Operio mobile (Toul Meditech, Operio®) versus an operating room setting. Results Use of the Operio mobile allowed the safety performance of 3838 IVIs during COVID-19 and significantly reduced the waiting time of the first visit. This results in a faster intervention without affecting the technical IVI procedure that remained unchanged comparing the two settings. Specifically, we observed a 26% reduction in operation costs for each IVI performed in the office, which can be translated to a higher impact when considering the total number of IVIs performed over one year. Conclusion The use of the Operio mobile in an ophthalmologist's office provides flexibility to perform IVIs, assuring patient safety, reducing healthcare personnel employment times, and the waiting lists for the patients, increasing the number of surgeries and improving the cost-effectiveness of the procedure.
Does Proximal Hamate Graft for Proximal Scaphoid Reconstruction Restore Native Wrist Kinematics?
Authors: Burnier Marion , Gil Joseph A. , Hooke Alexander , Elhassan Bassem , Kakar Sanjeev 
Published: February 2022

Background: The objective of this study was to determine whether reconstruction of the proximal pole of the scaphoid with a proximal hamate graft restores native carpal kinematics. Methods: A cadaveric study was designed assessing wrist kinematic after proximal hamate graft for proximal pole of the scaphoid nonunion. Wireless sensors were mounted to the carpus using a custom pin and suture anchor system to 8 cadavers. A wrist simulator was used to move the wrist through a cyclical motion about the flexion/extension and radial/ulnar deviation axes. Each specimen was tested under a series of 3 conditions: (1) a native state, “Intact”; (2) fractured scaphoid proximal pole, “Fracture”; and (3) post-reconstruction of the proximal pole of the scaphoid using a proximal hamate graft, “Graft.” Results: The fracture condition resulted in a statistically significant change in scapholunate kinematics across the entire arc of motion relative to the intact condition. Reconstruction with proximal hamate grafts restored scapholunate kinematics close to the intact state in both flexion/extension and radial/ulnar deviation axes. The lunocapitate flexion during wrist flexion was significantly different after the hamate graft reconstruction. Conclusions: Proximal hamate to scaphoid transfer resulted in restoration of near normal carpal kinematics to the intact state.
Serum Inflammatory Markers and Amputations in Hand Osteomyelitis: A Retrospective Review of 146 Cases
Authors: Wyman Matthew , Dargan Dallan , Kazzazi Diana , Caddick Jennifer , Giblin Victoria 
Published: February 2022

Background: The diagnosis of hand osteomyelitis requires correlation of clinical, radiological, and microbiological findings. The role of serum inflammatory markers in diagnosing and prognosticating hand osteomyelitis remains uncertain. We sought to determine the utility of inflammatory markers in the diagnosis and follow-up of hand osteomyelitis, and their ability to predict outcomes, particularly amputation. Methods: We retrospectively reviewed 146 patients diagnosed with hand osteomyelitis and with serum inflammatory marker levels measured after the onset of symptoms and within 14 days either side of diagnosis. Blood results at first presentation including white cell count (WCC), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) were reviewed, and associations with amputations assessed. Follow-up markers taken at 15 to 60 days from diagnosis were analyzed where available. Results: Mean WCC and CRP at diagnosis were 9.2 (SD: 4.6) and 30.2 (SD: 42.4) respectively, compared with 8.2 (SD: 3.9) and 30.2 (SD: 42.4) at follow-up. At diagnosis, sensitivity of CRP was 74%, and WCC was 31%. Each marker had a low positive predictive value for amputation at diagnosis (<29%). A rise in CRP between diagnosis and follow-up was associated with an increased risk of amputation compared with a fall in CRP. The finding that WCC and CRP were both normal at diagnosis had a high negative predictive value against amputation (96%). Conclusion: C-reactive protein has a higher sensitivity than WCC, NLR, and PLR when used as a diagnostic adjunct in hand osteomyelitis. White cell count and CRP both within reference ranges at diagnosis was highly negatively predictive against amputation.