bluuebunny/crossref_metadata_2025_split huggingface dataset:
A data-based parametrization of parton distribution functions
Authors: Carrazza Stefano , Cruz-Martinez Juan , Stegeman Roy 
Published: February 2022

AbstractSince the first determination of a structure function many decades ago, all methodologies used to determine structure functions or parton distribution functions (PDFs) have employed a common prefactor as part of the parametrization. The NNPDF collaboration pioneered the use of neural networks to overcome the inherent bias of constraining the space of solution with a fixed functional form while still keeping the same common prefactor as a preprocessing. Over the years various, increasingly sophisticated, techniques have been introduced to counter the effect of the prefactor on the PDF determination. In this paper we present a methodology to perform a data-based scaling of the Bjorken x input parameter which facilitates the removal the prefactor, thereby significantly simplifying the methodology, without a loss of efficiency and finding good agreement with previous results.
Ultrasonic Characteristics of Diastasis Recti Abdominis in Early Postpartum
Authors: Tan Lina , Ran Suzhen , Dong Hongmei , Wei Jun , Ran Haitao 
Published: February 2022

Objective. Explore the ultrasound characteristics of early postpartum Diastasis Recti Abdominis (DRA) and provide effective data support for its clinical diagnosis and treatment. Method. A total of 458 parturients who were diagnosed with DRA in the Chongqing Maternal and Child Health Hospital from December 2017 to September 2020 underwent postpartum ultrasound examinations. All of which were located at four points: 6 cm above the umbilicus (point 1), 3 cm above the umbilicus (point 2), umbilicus (point 3), and 3 cm below the umbilicus (point 4) to detect the interrectus distance (IRD) in the resting and sit-up state of the parturients postpartum and to study the differences in maternal age, weight, and ultrasound diagnosis of IRD at different stages after delivery. Results. The IRD values of the four measurement points in the resting state of the parturient were significantly greater than the IRD values in the sit-up state. And in the resting state, the IRD value (

4.31
±
1.07

cm

) of the point 3 region was the largest, and there were significant differences at different stages of the postpartum women. At the same time, the IRD values of points 3 and 4 have significant differences in parturient of different ages. In addition, the IRD values of the four measurement points of overweight women were higher than those of nonoverweight women. Conclusion. The umbilicus is the best ultrasound evaluation point for early postpartum DRA. The IRD value at this point in the resting state can be used as reference data for evaluating early postpartum DRA, which provides a useful reference for rapid postpartum recovery of parturients.
Rhombus-Inscribed Circular Ring Fractal Array Antenna for Millimeter-Wave 5G Applications
Authors: Tahir Muhammad Usman , Rafique Umair , Ahmed Muhammad Mansoor 
Published: February 2022

A 1

×

4 planar fractal array antenna is designed and presented for millimeter-wave 5G applications. The array’s top side is made up of a rhombus-inscribed circular ring fractal patch radiator, while the backside is made up of a square notch-loaded partial ground plane. To achieve high gain, a 1

×

4 corporate feeding network is used to excite the array elements. The designed array has an overall size of 28 × 17.75 mm2. From simulations as well as experimental results, it is observed that the designed array offers a wide impedance bandwidth in the frequency range of 22.8–29.2 GHz. Furthermore, a peak gain of 10.7 dBi with a radiation efficiency of

>

95% is observed in the operating bandwidth.
Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis
Authors: Wang Jin-Kai , Li Yang , Zhao Xiao-Lu , Liu Yuan-Bin , Tan Jing , Xing Yu-Ying , Adi Dilare , Wang Yong-Tao , Fu Zhen-Yan , Ma Yi-Tong , Liu Song-Mei , Liu Yong , Wang Yan , Shi Xiong-Jie , Lu Xiao-Yi , Song Bao-Liang , Luo Jie 
Published: February 2022

Background:
High blood cholesterol accelerates the progression of atherosclerosis, which is an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces thrombosis, which results in myocardial infarction or stroke. Lowering cholesterol levels is beneficial for preventing atherosclerotic cardiovascular disease.

Methods:

Low-density lipoprotein (LDL) receptor (LDLR) was used as bait to identify its binding proteins in the plasma, and the coagulation factor prekallikrein (PK; encoded by the
KLKB1
gene) was revealed. The correlation between serum PK protein content and lipid levels in young Chinese Han people was then analyzed. To investigate the effects of PK ablation on LDLR and lipid levels in vivo, we genetically deleted
Klkb1
in hamsters and heterozygous
Ldlr
knockout mice and knocked down
Klkb1
using adeno-associated virus-mediated shRNA in rats. The additive effect of PK and proprotein convertase subtilisin/kexin 9 inhibition also was evaluated. In addition, we applied the anti-PK neutralizing antibody that blocked the PK and LDLR interaction in mice. Mice lacking both PK and apolipoprotein e (
Klkb1
−/−
Apoe
–/–
) were generated to assess the role of PK in atherosclerosis.

Results:

PK directly bound LDLR and induced its lysosomal degradation. The serum PK concentrations positively correlated with LDL cholesterol levels in 198 young Chinese Han adults. Genetic depletion of
Klkb1
increased hepatic LDLR and decreased circulating cholesterol in multiple rodent models. Inhibition of proprotein convertase subtilisin/kexin 9 with evolocumab further decreased plasma LDL cholesterol levels in
Klkb1
-deficient hamsters. The anti-PK neutralizing antibody could similarly lower plasma lipids through upregulating hepatic LDLR. Ablation of
Klkb1
slowed the progression of atherosclerosis in mice on
Apoe
-deficient background.

Conclusions:
PK regulates circulating cholesterol levels through binding to LDLR and inducing its lysosomal degradation. Ablation of PK stabilizes LDLR, decreases LDL cholesterol, and prevents atherosclerotic plaque development. This study suggests that PK is a promising therapeutic target to treat atherosclerotic cardiovascular disease.
Representation of Lake–Atmosphere Interactions and Lake-Effect Snowfall in the Laurentian Great Lakes Basin among HighResMIP Global Climate Models
Authors: Notaro Michael , Jorns Jenna , Briley Laura 
Published: February 2022

Abstract
Credible modeling, tools, and guidance, regarding the changing Laurentian Great Lakes and the climatic impacts, are needed by local decision-makers to inform their management and planning. The present study addresses this need through a model evaluation study of the representation of lake–atmosphere interactions and resulting lake-effect snowfall in the Great Lakes region. Analysis focuses on an extensive ensemble of 74 historical simulations generated by 23 high-resolution global climate models (GCMs) from the High-Resolution Model Intercomparison Project (HighResMIP). The model assessment addresses the modeling treatment of the Great Lakes, the spatial distribution and seasonality of climatological snowfall, the seasonal cycle of lake-surface temperatures and overlake turbulent fluxes, and the lake-effect ratio between upwind and downwind precipitation. A deeper understanding of model performance and biases is achieved by partitioning results between HighResMIP GCMs that are 1) coupled to 1D lake models versus GCMs that exclude lake models, 2) between prescribed-ocean model configurations versus fully coupled configurations, and 3) between deep Lake Superior versus relatively shallow Lake Erie. While the HighResMIP GCMs represent the Great Lakes by a spectrum of approaches that include land grid cells, ocean grid cells (with lake surface temperature and ice cover boundary conditions provided by the Met Office Hadley Center Sea Ice and Sea Surface Temperature Dataset), and 1D lake models, the current investigation demonstrates that none of these rudimentary approaches adequately represent the complex nature of seasonal lake temperature and ice cover evolution and its impact on lake–atmosphere interactions and lake-effect precipitation in the Great Lakes region.

Significance Statement
The purpose of this study is to evaluate the capability of high-resolution global climate models to simulate lake–atmosphere interactions and lake-effect snowfall in the Great Lakes region, given the critical influence of the lakes on regional climate and vast societal and environmental impacts of lake-effect snowfall. It is determined that the models inadequately represent lake temperatures and ice cover, often leading to insufficient annual snowfall in the lake-effect zones. More advanced, three-dimensional lake models need to be coupled to climate models to support greater credibility in regional lake and climate simulations and future climate projections.
The Testing Effect in University Teaching: Using Multiple-Choice Testing to Promote Retention of Highly Retrievable Information
Authors: Greving Sven , Lenhard Wolfgang , Richter Tobias 
Published: February 2022

Background Retrieval practice promotes retention of learned information more than restudying the information. However, benefits of multiple-choice testing over restudying in real-world educational contexts and the role of practically relevant moderators such as feedback and learners’ ability to retrieve tested content from memory (i.e., retrievability) are still underexplored. Objective The present research examines the benefits of multiple-choice questions with an experimental design that maximizes internal validity, while investigating the role of feedback and retrievability in an authentic educational setting of a university psychology course. Method After course sessions, students answered multiple-choice questions or restudied course content and afterward could choose to revisit learning content and obtain feedback in a self-regulated way. Results Participants on average obtained corrective feedback for 9% of practiced items when practicing course content. In the criterial test, practicing retrieval was not superior to reading summarizing statements in general but a testing effect emerged for questions that targeted information that participants could easily retrieve from memory. Conclusion Feedback was rarely sought. However, even without feedback, participants profited from multiple-choice questions that targeted easily retrievable information. Teaching Implications Caution is advised when employing multiple-choice testing in self-regulated learning environments in which students are required to actively obtain feedback.
Evaluation of the sexual function of female partners of men with erectile dysfunction receiving different treatment modalities: An observational study
Authors: Nabil Ismail Nashaat , GamalEl Din Sameh Fayek , Abdel Raheem Amr , Rashad Esraa Mohamed , Farag Mohamed 
Published: February 2022

Objective: To evaluate sexual functions of patients with erectile dysfunction (ED) and their female partners. Methods: A total of 90 consecutive ED patients who received different ED therapies and their partners and 90 consecutive controls and their partners were divided into four groups. All participants were evaluated by the 15-item international index of erectile function and the Arabic version of female sexual function index (Ar-FSFI). Results: All ED patients who received sildenafil demonstrated significant improvements of their erectile function compared to baseline. Their partners did not demonstrate improvements in frequency of pain during vaginal penetration (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), confidence of becoming aroused (3.86 ± 0.58, 3.93 ± 0.45, p 0.477), frequency of satisfaction with arousal (3.07 ± 0.37, 3.03 ± 0.49, p 0.712), and maintenance of lubrication (4.37 ± 0.49, 4.23 ± 0.73, p 0.354). All ED patients who received quadmix demonstrated significant improvements of their erectile function compared to baseline. Their partners did not demonstrate improvements in desire level (2.6 ± 0.67, 2.63 ± 0.85, p = 0.869) and lubrication maintenance (3.53 ± 0.82, 3.47 ± 0.82, p = 0.423). Finally, All ED patients who underwent semi rigid penile implant demonstrated significant improvements of their erectile function compared to baseline. Their female partners demonstrated significant improvements in all items of FSFI-19 compared to baseline except the frequency of pain during vaginal penetration (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), confidence of becoming aroused (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), frequency of satisfaction with arousal (3.07 ± 0.37, 3.03 ± 0.49, p = 0.712), and maintenance of lubrication (4.37 ± 0.49, 4.23 ± 0.73, p = 0.354). Conclusions: Sexual functions of ED males significantly improved after ED therapies. Nevertheless, some sexual functions of their partners were not positively impacted.
Remdesivir and Human Milk: A Case Study
Authors: Wada Yuka Sano , Saito Jumpei , Hashii Yuko , Kishi Tomomi , Kobayashi Masayuki , Kamiya Taro , Mizuno Katsumi 
Published: February 2022

Introduction: Remdesivir was originally developed to treat Ebola hemorrhagic fever, and its efficacy in treating coronavirus disease 2019 was detected during a preliminary analysis of a randomized controlled trial. It is known that Severe Acute Respiratory Syndrome Coronavirus 2 is not transmitted through human milk, but data about the presence of remdesivir in human milk have been lacking. Main issue: In this case study, we determined the human milk-to-serum drug concentration ratio and the relative dose of Remdesivir in one participant. Management: The participant, a 28-year-old primipara, was found to have Coronavirus 2 infection in 2019, 2 days after delivery. She was given Remdesivir. The Remdesivir concentration in maternal serum and human milk was measured, and the milk-to-serum drug concentration ratio was found to be low (0.089), as was the relative infant dose (0.0070). The participant could not breastfeed her infant during her Coronavirus 2 infection treatment because in Japan anyone with COVID-19 was completely quarantined. However, she was able to resume breastfeeding after discharge and breastfed her infant for 6 months with supplements. Conclusion: Given the low amount of Remdesivir in the participant’s milk, the inclusion of antibodies to Severe Acute Respiratory Syndrome Coronavirus 2, which can be expected to protect the infant from infection, and various other benefits of human milk, suggests that breastfeeding is safe during treatment with Remdesivir.
Psychological Distress, Coping Strategies, and Quality of Life in Breast Cancer Patients Under Neoadjuvant Therapy: Protocol of a Systematic Review
Authors: Omari Majid , Zarrouq Btissame , Amaadour Lamiae , Benbrahim Zineb , El Asri Achraf , Mellas Nawfel , El Rhazi Karima , Ragala Mohammed El Amine , Halim Karima 
Published: February 2022

Introduction Women with breast cancer eligible for neoadjuvant therapy (NAT) present a disorder of biopsychosocial variables and alteration of their quality of life. They cope with this changing by adopting psychological adjustment strategies, either passive or active. This systematic review aims to investigate the psychological distress, coping strategies, and quality of life in breast cancer patients under neoadjuvant therapy. Methods Cochrane Library, PubMed, ScienceDirect, Scopus, Web of Science, and Wiley Online library represent the databases that were searched to identify relevant published articles until September 27, 2021. Full-text published articles, written in English and assessing the main outcomes (namely: psychological distress, coping strategies, and quality of life) in women with breast cancer under NAT will be included. Also, we will integrate papers dealing with the related bio psychosocial variables to the main variables. The paper selection, data extraction, and quality assessment of selected studies will be performed independently by two researchers, and disagreements will be resolved through discussions. We will bring together the results of all of the included studies to draw conclusions based on the body of evidence. The narrative approach will be adopted to analyze the results and conclusions extracted and we would perform quantitative groupings if we have similar data. Ethics and dissemination Ethical approval is not required as the proposed systematic review will not use primary data. The results of this review will be disseminated through publication in a peer-reviewed journal and conference presentation(s). PROSPERO registration number: CRD42021230300.
Innovative Quantitative Assessment of Hand Function in Carpal Tunnel Syndrome
Authors: Alloisio Susanna , Mennella Ciro , Viti Federica , Novellino Antonio , Tognon Stefano 
Published: February 2022

Background: Carpal tunnel syndrome (CTS) compromises fine sensorimotor function during activities of daily living and affects a large number of individuals with high burden costs for society. The purpose of this study was to quantitatively characterize fine movement skills in CTS patients preoperatively and at 1 month postoperatively by means of a sensor-engineered glove, in order to provide new insights for evaluative and finally therapeutic purposes. Methods: Forty-one CTS patients and 41 age- and gender-matched healthy controls (HC) were analyzed by adopting the engineered glove Hand Test System (HTS), which previously demonstrated its reliability and sensitivity to detect hands dysfunction in several neurological diseases. A sub-group of 11 CTS subjects was re-tested 1 month after surgery. Three parameters—touch duration (TD), inter-tapping interval (ITI), and movement rate (MR)—were considered to characterize hand function. Results: The affected hand of CTS patients generally showed worst finger opposition performances than HC. Comparing the dominant hand, all parameters were able to significantly discriminate CTS patients from HC. Considering the nondominant hand, the best performing parameter in discriminating CTS from HC was TD. The follow-up assessment at 1 month after surgery showed that considered parameters were able to monitor patients’ recovery. In particular, the TD parameter recorded at the 3 different assigned task modalities resulted significantly enhanced. Conclusions: Results of this pilot study proved the validity of the parameters obtained through the sensor-engineered glove to assess objectively hand functional status and surgical outcomes in CTS.
Engineering of Tracheal Grafts Based on Recellularization of Laser-Engraved Human Airway Cartilage Substrates
Authors: Baranovskii Denis , Demner Jan , Nürnberger Sylvia , Lyundup Alexey , Redl Heinz , Hilpert Morgane , Pigeot Sebastien , Krasheninnikov Michael , Krasilnikova Olga , Klabukov Ilya , Parshin Vladimir , Martin Ivan , Lardinois Didier , Barbero Andrea 
Published: February 2022

Objective Implantation of tissue-engineered tracheal grafts represents a visionary strategy for the reconstruction of tracheal wall defects after resections and may develop into a last chance for a number of patients with severe cicatricial stenosis. The use of a decellularized tracheal substrate would offer an ideally stiff graft, but the matrix density would challenge efficient remodeling into a living cartilage. In this study, we hypothesized that the pores of decellularized laser-perforated tracheal cartilage (LPTC) tissues can be colonized by adult nasal chondrocytes (NCs) to produce new cartilage tissue suitable for the repair of tracheal defects. Design Human, native tracheal specimens, isolated from cadaveric donors, were exposed to decellularized and laser engraving–controlled superficial perforation (300 μm depth). Human or rabbit NCs were cultured on the LPTCs for 1 week. The resulting revitalized tissues were implanted ectopically in nude mice or orthotopically in tracheal wall defects in rabbits. Tissues were assayed histologically and by microtomography analyses before and after implantation. Results NCs were able to efficiently colonize the pores of the LPTCs. The extent of colonization (i.e., percentage of viable cells spanning >300 μm of tissue depth), cell morphology, and cartilage matrix deposition improved once the revitalized constructs were implanted ectopically in nude mice. LPTCs could be successfully grafted onto the tracheal wall of rabbits without any evidence of dislocation or tracheal stenosis, 8 weeks after implantation. Rabbit NCs, within the LPTCs, actively produced new cartilage matrix. Conclusion Implantation of NC-revitalized LPTCs represents a feasible strategy for the repair of tracheal wall defects.
Association of primary Sjögren’s syndrome with incident heart failure: a secondary analysis of health claims data in Taiwan
Authors: Lin Chun-Yu , Chen Hung-An , Chang Tsang-Wei , Hsu Tsai-Ching , Hsu Chung-Yuan , Su Yu-Jih 
Published: February 2022

Objective: Mounting evidence has demonstrated that various chronic inflammatory diseases are associated with incident heart failure (HF). However, there is scarce evidence about the association between primary Sjögren’s syndrome (pSS) and HF. We aimed to explore this association using a nationwide database in Taiwan. Methods: We selected patients with incident pSS and no history of HF. Using propensity score matching based on age, sex, cohort entry time, comorbidities, and concomitant medications, cohorts of patients with and without pSS (as controls) were created in a 1:1 ratio and the groups were compared. The cumulative incidence of HF was calculated using Kaplan–Meier estimation. Cox proportional hazard regression analysis was used to measure the hazard ratio (HR) of HF-related hospitalization for the pSS cohort compared with the comparison group. Results: A total of 16,466 pairs of patients with pSS and those without pSS were identified. The cumulative incidence of HF-related hospitalization at 3, 5, and 10 years in patients with pSS was 1.05%, 1.89%, and 4.33%, respectively. The risk of HF-related hospitalization was not higher in patients with pSS than in the general population (HR: 0.98, 95% confidence interval [CI]: 0.84–1.14). There was no difference in survival probability after the first episode of HF-related hospitalization between pSS and non-pSS groups. Conclusion: Our results suggest that distinct inflammatory spectrums in each chronic inflammatory disease might have differential impacts on cardiac function and subsequent risk of HF. Future studies are needed to elucidate the complex and diverse mechanisms of HF in various chronic autoimmune diseases.