bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of Upper Limb Injuries in two major Brazilian Soccer Championships from 2016 to 2019
Authors: de Souza Lima Ewerton Borges , de Godoy Gabriel Paris , Osés Guilherme Ladeira , Lara Paulo Henrique Schmidt , Ribeiro Leandro Masini , Andreoli Carlos Vicente , de Castro Pochini Alberto , Belangero Paulo Santoro , Arliani Gustavo Gonçalves , Ejnisman Benno , Cohen Moisés 
Published: December 2022

Abstract
Purpose
To evaluate epidemiological data of upper limb injuries in professional athletes who participated in two major Brazilian soccer championships between 2016 and 2019.

Methods
A prospective cohort study was conducted to evaluate the teams of two divisions over four seasons within the Brazilian Soccer Championship and the Paulista Soccer Championship. Clubs and their doctors were contacted to participate in the study and guided on the correct way to enter data via online platforms: Transfermarkt (Transfermarkt GmbH & Co. KG) and Survey Monkey (Momentive.AI). Demographic data, injury characteristics, and FIFA Incidence Formula were analyzed.

Results
Overall, the study analyzed 3,828 matches and 126,357 hours of play. Upper limb injuries were registered 169 times, representing 6.8% of total injuries, with a FIFA incidence of 1.34. Most lesions occurred in forward players (21.3%), the shoulder exhibited the highest number of injuries (63.3%). The player’s position was related to the location on the field where the injury occurred (p < 0.001); however, there was no relationship between the type of injury and the location on the body (p > 0.001). The average time to return to play was 19.1 days (range 0–200 days) and it was longer for goalkeepers. The necessity of surgical treatment was statistically associated with additional time to return to play (p < 0.001).

Conclusions
Shoulder injuries were the most frequent upper limb injury sustained during the two major Brazilian soccer championships. Forward players suffered the most upper limb injuries and goalkeepers experienced the longest time to return to play.
ACL microtrauma: healing through nutrition, modified sports training, and increased recovery time
Authors: Nyland J. , Pyle B. , Krupp R. , Kittle G. , Richards J. , Brey J. 
Published: December 2022

Abstract
Purpose
Sports injuries among youth and adolescent athletes are a growing concern, particularly at the knee. Based on our current understanding of microtrauma and anterior cruciate ligament (ACL) healing characteristics, this clinical commentary describes a comprehensive plan to better manage ACL microtrauma and mitigate the likelihood of progression to a non-contact macrotraumatic ACL rupture.

Methods
Medical literature related to non-contact ACL injuries among youth and adolescent athletes, collagen and ACL extracellular matrix metabolism, ACL microtrauma and sudden failure, and concerns related to current sports training were reviewed and synthesized into a comprehensive intervention plan.

Results
With consideration for biopsychosocial model health factors, proper nutrition and modified sports training with increased recovery time, a comprehensive primary ACL injury prevention plan is described for the purpose of better managing ACL microtrauma, thereby reducing the incidence of non-contact macrotraumatic ACL rupture among youth and adolescent athletes.

Conclusion
Preventing non-contact ACL injuries may require greater consideration for reducing accumulated ACL microtrauma. Proper nutrition including glycine-rich collagen peptides, or gelatin-vitamin C supplementation in combination with healthy sleep, and adjusted sports training periodization with increased recovery time may improve ACL extracellular matrix collagen deposition homeostasis, decreasing sudden non-contact ACL rupture incidence likelihood in youth and adolescent athletes. Successful implementation will require compliance from athletes, parents, coaches, the sports medicine healthcare team, and event organizers. Studies are needed to confirm the efficacy of these concepts.

Level of evidence
V
Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation
Authors: Zhao Jingsha , Fu Hao , Zhang Yongtao , Li Meng , Wang Dongdong , Zhao Dan , Zhang Jiachan , Wang Changtao 
Published: December 2022

AbstractUltraviolet rays in sunlight can cause skin damage and premature aging. This study demonstrates that Lactobacillus reuteri SJ-47 strain exopolysaccharides (EPS) protect human skin fibroblasts (HSF) under UVA radiation. During the course of the experiments, we investigate the oxidative stress protection and antiaging effects of exopolysaccharides on HSF at the biochemical, cellular, and molecular levels. The results show that EPS can increase the antioxidant capacity of cells, decrease the amount of reactive-oxygen species (ROS) and malondialdehyde (MDA), while improve the expression of antioxidant enzymes. At the same time, EPS can increase collagen content, which can effectively regulate the expression of genes in the senescence and apoptosis pathways, and delay skin photoaging caused by UVA irradiation.
Graphical Abstract
Utilization of durian seed for Monascus fermentation and its application as a functional ingredient in yogurt
Authors: Srianta Ignatius , Kuswardani Indah , Ristiarini Susana , Kusumawati Netty , Godelive Laura , Nugerahani Ira 
Published: December 2022

AbstractAs a widely consumed fermented milk product, yogurt undergoes constant development to increase its functional properties. Monascus purpureus-fermented durian seed, which has been proven to possess antioxidative properties, has the potential to improve yogurt properties. This study aimed to analyze the use of Monascus-fermented durian seed (MFDS) as a functional ingredient in yogurt and its effect on physicochemical properties, lactic acid bacteria (LAB) count, antioxidative properties, and consumer acceptability of set-type yogurt during refrigeration. Changes in physicochemical properties, including color, pH, titratable acidity, syneresis, LAB count, total phenolic content (TPC), and antioxidant activity were evaluated at 7-day intervals during 14 days of refrigerated storage (4 °C). Sensory evaluations were carried out for freshly made samples after 7 days of storage. The results showed that the addition of MFDS to yogurt gave significant effects on some of the parameters measured. Yogurt with added MFDS powder produced a more red color (L = 88.55 ± 1.28, a* = 2.63 ± 0.17, b* = 11.45 ± 1.15, c = 11.75 ± 1.15, H = 77.00 ± 0.64), reached the highest TPC (2.21 ± 0.46 mg/GAE g), antioxidant activity (0.0125 ± 0.0032 mg GAE/g), and syneresis (5.24 ± 0.51%) throughout 14 days of storage. The addition of MFDS only gave a slight difference to pH and titratable acidity, while no significant difference was made for LAB count. For sensory evaluation, the addition of MFDS, particularly the ethanol extract, to yogurt was well-liked by panelists. Citrinin content in MFDS yogurt can be decreased under the limits set. Overall, the addition of MFDS has a high potential of improving yogurt properties, particularly its antioxidative properties.
Graphical Abstract
Effect of wither application of an analogue of pig appeasing pheromone on encounters between unfamiliar mini-pigs
Authors: Marcet-Rius Míriam , Mendonça Tiago , Pageat Patrick , Arroub Sana , Bienboire-Frosini Cécile , Chabaud Camille , Teruel Eva , Cozzi Alessandro 
Published: December 2022

AbstractBackgroundThe practice of mixing unfamiliar pigs on farms is common but results in fighting, welfare problems and performance issues. Pigs have different ways of resolving social conflicts, including aggressive and affiliative behaviours. Synthetic appeasing pheromones have demonstrated many positive effects in animal husbandry and are regularly used by breeders to improve animal welfare and performance. The aim of the study was to investigate the effect of a new method of applying pig appeasing-pheromone (PAP) to the withers in an experimental model of pig mixing to determine whether PAP reduced aggression and fighting, increased prosocial behaviours, and improved behavioural and physiological indicators of welfare.ResultsPAP reduced fighting between mini-pigs (df = 1; F = 13.47;P = 0.001; mixed logistic regression). Even if not significant, agonistic behaviours tended to be reduced when the treatment was applied (df = 1; F = 4.14;P = 0.058; mixed logistic regression). Likewise, mini-pigs seemed to be scored as not aggressive at all (df = 1; F = 3.61;P = 0.070; GLMM) and to be less aggressive toward the other pig than when placebo was applied. Concerning the latency of the first contact without aggression, a significant effect was found between the PAP and placebo groups (df = 1;χ2 = 4.74;P = 0.0295; Cox model). Moreover, even if not significant, the treated mini-pigs seemed to spent more time looking at each other (df = 1; F = 3.59;P = 0.071; GLMM) and immobile and/or ground sniffing (df = 1; F = 3.18;P = 0.088; GLMM) than those that received placebo. No significant difference was found between groups for salivary cortisol concentration (df = 1; F = 0.10;P = 0.752; GLMM), but variances between groups were heterogeneous at every time. No significant difference was found between groups regarding alpha-amylase activity (df = 1; F = 0.25;P = 0.621; GLMM), but variances between groups were heterogeneous at T0, T1 and T3. These results indicate that the variability (dispersion) within each group was lower when PAP was applied than when the placebo was applied.ConclusionsThe new method of applying PAP improved welfare of mini-pigs (as models of domestic pigs) by reducing fighting, among other interesting results. PAP seems thus a promising biomimetic tool to enhance animal welfare in pig production systems.
Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration
Authors: Foroushani Fatemeh Tavakoli , Dzobo Kevin , Khumalo Nonhlanhla P , Mora Vanessa Zamora , de Mezerville Roberto , Bayat Ardeshir 
Published: December 2022

Abstract
Silicone breast implants are commonly used for cosmetic and oncologic surgical indications owing to their inertness and being nontoxic. However, complications including capsular contracture and anaplastic large cell lymphoma have been associated with certain breast implant surfaces over time. Novel implant surfaces and modifications of existing ones can directly impact cell-surface interactions and enhance biocompatibility and integration. The extent of foreign body response induced by breast implants influence implant success and integration into the body. This review highlights recent advances in breast implant surface technologies including modifications of implant surface topography and chemistry and effects on protein adsorption, and cell adhesion. A comprehensive online literature search was performed for relevant articles using the following keywords silicone breast implants, foreign body response, cell adhesion, protein adsorption, and cell-surface interaction. Properties of silicone breast implants impacting cell-material interactions including surface roughness, wettability, and stiffness, are discussed. Recent studies highlighting both silicone implant surface activation strategies and modifications to enhance biocompatibility in order to prevent capsular contracture formation and development of anaplastic large cell lymphoma are presented. Overall, breast implant surface modifications are being extensively investigated in order to improve implant biocompatibility to cater for increased demand for both cosmetic and oncologic surgeries.
Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death
Authors: Yamada Hiroki , Kase Yoshitaka , Okano Yuji , Kim Doyoon , Goto Maraku , Takahashi Satoshi , Okano Hideyuki , Toda Masahiro 
Published: December 2022

Abstract
Background
Subarachnoid hemorrhage (SAH) is a fatal disease, with early brain injury (EBI) occurring within 72 h of SAH injury contributes to its poor prognosis. EBI is a complicated phenomenon involving multiple mechanisms. Although neuroinflammation has been shown to be important prognosis factor of EBI, whether neuroinflammation spreads throughout the cerebrum and the extent of its depth in the cerebral cortex remain unknown. Knowing how inflammation spreads throughout the cerebrum is also important to determine if anti-inflammatory agents are a future therapeutic strategy for EBI.

Methods
In this study, we induced SAH in mice by injecting hematoma into prechiasmatic cistern and created models of mild to severe SAH. In sections of the mouse cerebrum, we investigated neuroinflammation and neuronal cell death in the cortex distal to the hematoma injection site, from anterior to posterior region 24 h after SAH injury.

Results
Neuroinflammation caused by SAH spread to all layers of the cerebral cortex from the anterior to the posterior part of the cerebrum via the invasion of activated microglia, and neuronal cell death increased in correlation with neuroinflammation. This trend increased with the severity of the disease.

Conclusions
Neuroinflammation caused by SAH had spread throughout the cerebrum, causing neuronal cell death. Considering that the cerebral cortex is responsible for long-term memory and movement, suppressing neuroinflammation in all layers of the cerebral cortex may improve the prognosis of patients with SAH.
Transportability Methods for Time-to-Event Outcomes: Application in Adjuvant Colon Cancer Trials
Authors: Zuo Shuozhi , Josey Kevin P. , Raghavan Sridharan , Yang Fan , Juaréz-Colunga Elizabeth , Ghosh Debashis 
Published: December 2022

PURPOSEDifferences in the benefits of treatment on 5-year overall survival have been observed in 12 randomized phase III colon cancer adjuvant clinical trials from the ACCENT group. We investigated the reasons for these differences by incorporating the distribution of the observed covariates from each trial.MATERIALS AND METHODSWe applied state-of-the-art transportability methods on the basis of causal inference, and compared them with a conventional meta-analysis approach to predict the treatment effect for the target population. Prediction errors were defined to evaluate whether the identifiability conditions necessary for causal inference were satisfied among the 12 trials, and to measure the performance of each method.RESULTSIn the one-trial-at-a-time transportability analysis, the ranks of prediction errors for the target population were mostly consistent with the discrepancy in treatment effects among the 12 trials across the three models. The overall prediction errors between the leave-one-trial-out transportability method and the conventional individual participant data meta-analysis approach were very similar, and more than 40% lower than the overall prediction errors from the one-trial-at-a-time transportability method.CONCLUSIONThe discrepancy in treatment effects among the 12 trials is unlikely to arise from the choice of model specification or distribution of observed covariates but from the distribution of unobserved covariates or study-level features. The ability to quantify heterogeneity among the 12 trials was greatly reduced in both the leave-one-trial-out transportability method and the conventional meta-analysis approach compared with the one-trial-at-a-time transportability method.
On the derivation of the generalized Langevin equation and the fluctuation-dissipation theorem
Authors: Vroylandt Hadrien 
Published: December 2022

Abstract
The generalized Langevin equation is widely used to model the effective dynamics of chemical, soft or biological systems. It is used to describe the evolution of a small number of collective variables, and is derived using the projection operator formalism. However, the validity of the derivation of the generalized Langevin equation in systems featuring non-linear potential of mean force is presently questioned. In this paper, we rigorously derive, using a two-projection operator formalism, the usual form of the generalized Langevin equation with non-linear potential of mean force and constant memory kernel. We show that the usual fluctuation-dissipation theorem is violated and a modified version should be considered. We also illustrate this violation on a numerical example.
Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients
Authors: Ettleson Matthew D , Prieto Wesley H , Russo Pedro S T , de Sa Jose , Wan Wen , Laiteerapong Neda , Maciel Rui M B , Bianco Antonio C 
Published: December 2022

Abstract

Context
Small adjustments in levothyroxine (LT4) dose do not appear to provide clinical benefit despite changes in thyrotropin (TSH) levels within the reference range. We hypothesize that the accompanying changes in serum total triiodothyronine (T3) levels do not reflect the magnitude of the changes in serum TSH.

Objective
This work aims to characterize the relationships of serum free thyroxine (FT4) vs T3, FT4 vs TSH, and FT4 vs the T3/FT4 ratio.

Methods
This cross-sectional, observational study comprised 9850 participants aged 18 years and older treated with LT4 from a large clinical database from January 1, 2009, to December 31, 2019. Patients had been treated with LT4, subdivided by serum FT4 level. Main outcome measures included model fitting of the relationships between serum FT4 vs TSH, FT4 vs T3, and FT4 vs T3/FT4. Mean and median values of TSH, T3, and T3/FT4 were calculated.

Results
The relationships T3 vs FT4 and TSH vs FT4 were both complex and best represented by distinct, segmented regression models. Increasing FT4 levels were linearly associated with T3 levels until an inflection point at an FT4 level of 0.7 ng/dL, after which a flattening of the slope was observed following a convex quadratic curve. In contrast, increasing FT4 levels were associated with steep declines in TSH following 2 negative sigmoid curves. The FT4 vs T3/FT4 relationship was fit to an asymptotic regression curve supporting less T4 to T3 activation at higher FT4 levels.

Conclusion
In LT4-treated patients, the relationships between serum FT4 vs TSH and FT4 vs T3 across a range of FT4 levels are disproportionate. As a result, dose changes in LT4 that robustly modify serum FT4 and TSH values may only minimally affect serum T3 levels and result in no significant clinical benefit.
Religious Distinctions
Authors: Balboni Philip 
Published: December 2022

Abstract
This essay works to clarify Edward Said’s writings on religion, criticism, and the secular, arguing that this clarification has serious implications not only for Said’s project of “secular criticism” but also for understanding the workings of what he called the “critical consciousness” within a “purely secular view of reality.” The essay holds that there are not one but two concepts of the religious operative in Said’s work and maintains that most commentators on Said have ignored the second concept and have therefore misconstrued secular criticism’s relationship to what it nominates as religious. By reexamining Said’s writings on religion, criticism, and the secular, as well as his early studies of modern literature, this essay contends that a secular criticism aware of its commitment to both concepts of the religious allows for a more nuanced and powerful account of the manner in which such criticism can call itself secular. It suggests, furthermore, that this account not only clarifies the workings of Said’s own critical consciousness but also provides a likewise more nuanced view of the “method” or “rationality” such a consciousness deploys in making sense of human life, ingenuity, and history.
Under Construction
Authors: Nancy Jean-Luc 
Published: December 2022

Abstract
Jean-Luc Nancy published four times in Qui Parle during his lifetime: once in 1987, once in 1989, and twice in 2017. “Under Construction: Interventions” marks the first English translation of his first publication in this journal, in its second-ever issue. In this short piece, written five years after his groundbreaking La communauté désoeuvrée, Nancy takes up the question of teaching and its inherent entwinement, as he argues, with “the work of thought.” Teaching is here understood much like Nancy’s community: not as what stems from collaboration but as comprising a series of mimetic displacements, reproductions, gestures. Teaching thus magnifies the possibilities at “the limit of sense.” As Nancy puts it: the reconfiguration of those listening students will continue its reach where a teacher’s mastery has reached its finitude. Amid contemporary conversations about collaborative learning and pedagogical missions, Nancy’s brief missive offers a compelling intervention—an alternative model to that of master and pupil—but envisions a classroom community built on layers of displacement.
Nancy’s Prophetic Voice
Authors: James Ian 
Published: December 2022

Abstract
This article gives a personal recollection of discussions with Jean-Luc Nancy and offers a reflection on these together with a philosophical analysis of texts written by him that were published in 2020 in the volume La peau fragile du monde (The Fragile Skin of the World). It engages with Nancy’s novel understanding of prophecy to understand his own writing as a form of “prophetic voice” receptive to the emergence of the present and its opening onto the future. A meditation on time, the loss of history, and on the need to be receptive to what comes to us as the real and from the real, the article outlines Nancy’s singular, generous, and open praxis and ethos of thought.
Does Social Influence Change with Other Information Sources? A Large-Scale Randomized Experiment in Medical Crowdfunding
Authors: Hur Yun Young , Jin Fujie , Li Xitong , Cheng Yuan , Hu Yu Jeffrey 
Published: December 2022

We examine how social influence interacts with other information sources to affect user behaviors in the context of medical crowdfunding. We conduct a large-scale randomized field experiment on a leading medical crowdfunding platform, showing friends’ donation information to donors in the treatment group and not showing such information in the control group, and examine how the likelihood to donate differs. In addition, we conduct a survey on Amazon Mechanical Turk to evaluate the informational value of different case attributes in conveying the patients’ need for help to donors. We find that for cases containing attributes with high informational value (e.g., minor patient, severe conditions), social influence is insignificant. In contrast, for cases lacking attributes with high informational value, social influence significantly increases donors’ likelihood to donate. Overall, our results show that the impact of social influence depends on the informational value of other information sources, suggesting that the social influence in our context is primarily informational. Our findings indicate that rather than generating an entrenchment effect, where cases with attributes of high informational value attract disproportionate benefits, social influence can increase donation likelihood to cases that lack such attributes, promoting more equal access to resources overall. History: Olivia Liu Sheng, Senior Editor; Yuliang (Oliver) Yao, Associate Editor. Supplemental Material: The online appendices are available at https://doi.org/10.1287/isre.2022.1189 .