bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of promotor -21 A/T polymorphism of catalase CAT (rs7943316) gene in patients with breast cancer
Authors: Abdulabbas Hadi Sajid , Al-Mawlah Yasir Haider , Shaheed Salah Hashim , Jebor Mohammed Abdullah , Ali Suroor Mohammed 
Published: November 2022

Abstract
Oxidative stress is implicated in many forms of cancer, and catalase is one of the most critical enzymes involved in the organic body's defensive mechanism against stress on antioxidation. Catalase shows a vital role in the body's primary defense versus oxidative stress. Several studies have indicated that CAT gene polymorphism plays an essential role in the pathogenesis of cancer. This study aimed to recognize the influence of the CAT (rs7943316) gene polymorphism on breast cancer progress in patients using a collection of blood samples from each subject. After the extraction of genomic DNA, the SNP rs7943316 analysis was performed using PCR, RFLP, and electrophoresis on agarose. finally visualized under UV light and analyzed with SPSS software (version 23). This study revealed that the higher genotype in the control subjects was AT genotype 19 (63.3%), followed by TT genotype 11 (36.7%), and AA genotype (0%). In the BC group, AT genotype was the higher 39 (55.7%), followed by TT genotype 24 (34.3%), and AA genotype 7 (10.0%). Individual carriers of the A/T and T/T type of genotype were less expected to develop BC [OR = 0.135, 95% CI = 0.0073-2.4882, P value = 0.178] and [OR = 0.1420, 95% CI = 0.0075-2.70, P value = 0.1943], respectively. In addition, there are no significant differences in frequencies of the T allele of the CAT gene (rs7943316) between breast cancer patients and control groups [OR = 0.67, 95% CI = 0.4002-1.4459, P value = 0.4039]. In brief, the current study’s results suggest no correlation between rs7943316 polymorphisms of CAT genes and the development of BC; the genotypes AA, AT, and TT have no potential risk for breast cancer in patient women.
Preparation of sodium alginate films incorporated with hydroalcoholic extract of Macrocystis pyrifera L.
Authors: Ramos Judith , Villacrés Nelson Adrián , Cavalheiro Éder Tadeu Gomes , Alarcón Hugo A. , Valderrama Ana C. 
Published: November 2022

Agroindustry needs novel materials to replace synthetic plastics. This article introduces sodium alginate films with antioxidant properties. The films, which were incorporated with hydroalcoholic extract of Macrocystis pyrifera L., were tested on sliced Hass avocados.
The research featured sodium alginate films incorporated with hydroalcoholic extracts of M. pyrifera. Uncoated avocado halves served as control, while the experimental samples were covered with polymer film with or without hydroalcoholic extract. A set of experiments made it possible to evaluate the effect of the extracts on polymeric matrices, release kinetics, and sensory profile of halved Hass avocados.
A greater concentration of hydroalcoholic extracts increased the content of phenolic compounds and their antioxidant activity. As a result, the bands in the carboxylate groups of sodium alginate became more intense. Crystallinity decreased, whereas opacity and mass loss percentage increased, and conglomerates appeared on the surface of the films. These processes fit the KorsmeyerPeppas kinetic model because they resulted from a combination of diffusion and swelling mechanisms in the films.
The films incorporated with hydroalcoholic extract of M. pyrifera proved to be an effective alternative to traditional fruit
wrapping materials.
The Integration of Transportation Modes for Bromo-Tengger-Semeru National Park
Authors: Priyambodo  , Hamid Abdul , Buditiawan Kristian , Setyawan Dendy , Adi Ari Sasmoko , Gartika Dewi , Suroso  , Alita Endriana Wahyu , Momon  
Published: November 2022

Introduction:
The spread of the COVID-19 virus requires unprecedented steps from the government such as the restriction of travelers and activities and enforcement of social distancing to reduce interaction between individuals. This led to a drastic decrease in tourist visits to the TN-BTS between January and December 2020 with the area reported having been closed between April - July. Meanwhile, there was an inadequate transportation system at a tourist destination area before the pandemic and that made the movement more difficult during the pandemic. Therefore, this research is focused on describing transportation modes integration in the East Java-Indonesia TN-BTS area during this period.

Methods:
The intermodal integration was represented through the community's preference which was based on certain elements such as the need for connecting mode, main mode, multimodal network, transitional facilities, switching facilities with different networks, schedules integration, tariffs, routes, and times.

Results and Discussion:
The survey conducted, however, showed these indicators are below expectation as observed with the community satisfaction with transportation integration in the TN-BTS area measured to be very low, below 60%, using the Customer Satisfaction Index (CSI) tool. Moreover, the expectations on the variables for intermodal integration were also measured using Important Performance Analysis (IPA).

Conclusion:
The findings showed the policymakers and planners need to take steps to encourage the realization of transportation integration in the TN-BTS area to develop tourism in the area.
"Li buffoni", Fessa e la nuova malmaritata di Margherita Costa
Authors: Goethals Jessica 
Published: November 2022

La prima commedia pubblicata in Italia da una donna fu Li buffoni di Margherita Costa (1641). Commedia ridicolosa, l’opera è una parodia della corte Medicea ambientata in nord Africa. Il presente studio considera la protagonista Marmotta, principessa di Fessa e moglie del principe di Marocco, come una rivisitazione innovativa del topos della malmaritata. Essa non è la moglie annoiata e adultera o la giovinetta desiderosa di evitare un’unione sgradita, ma una sposa i cui appetiti amorosi rimangono insoddisfatti perché il marito preferisce la compagnia di nani, gobbi, matti e altri ‘scherz[i] di natura’ del principato. Il saggio legge Li buffoni come una sfida fatta da una scrittrice ai luoghi comuni del mondo teatrale sul desiderio femminile.
Keywords: Margherita Costa, «malmaritata», gender, burlesco, commedia
Conceptualizing Early Modern Metropolitan Space in Giovan Battista della Porta’s Comedy "Tabernaria" (1616). The Osteria del Cerriglio in Naples
Authors: Kodera Sergius 
Published: November 2022

This contribution examines a particular instance in which two different ways of perceiving metropolitan space in 17th century Naples (espace véçu and espace conçu) become imbricated in the mode of comedy. Tabernaria stages not merely the place of the Osteria del Cerriglio, a historic urban site; through a characteristic mise en abîme, this scenic re-creation is doubled or mirrored in a theatrical place which only pretends to be the Cerriglio. Likewise, and again typical for this narrative strategy, the staged play itself is doubled by the ruse enacted by some of the personae for (or rather: against) other personae onstage. The audiences may then enjoy this oblique representation of a very real metropolitan space and its labyrinthine pitfalls, from a safe distance.
Keywords: Naples, theater and space, espace véçu, espace conçu, Baratta map
Aproximación a las críticas portuguesas del siglo XVIII sobre poesía barroca Política, ideología y transición del gusto
Authors: Miranda Alma Delia 
Published: November 2022

El objetivo de este trabajo es revisar las opiniones sobre la poesía barroca vertidas en paratextos de la Fénix Renascida, así como en revisiones del estado de la poesía portuguesa en el siglo XVIII: Carta VII del Verdadeiro Método de Estudar, de Luís António Verney; algunas de las Orações y Dissertações de Correia Garção; Nova arte de conceitos, de Leitão Ferreira; y Exame crítico de Valadares Sousa, y dilucidar si las motivaciones de estas ideas son de tipo político, ideológico o estético.
Keywords: Poesía barroca, Luís António Verney, Correia Garção, Nova arte de conceitos, Exame crítico.
Gongorismo, religión y política en Luis de Tovar
Authors: Alonso Álvaro 
Published: November 2022

El presente trabajo se centra en el casi desconocido poeta portugés Luis de Tovar, autor de un poema épico en castellano sobre San Antonio de Padua. Tomando como punto de partida el poema, se intenta precisar cuáles fueron las relaciones de su autor con la monarquía de los Austrias y su capital, Madrid, durante el reinado de Felipe III. El profundo apego de Tovar a su patria no implica en él anticastellanismo ni hostilidad hacia la dinastía reinante, aunque sí parece haber lamentado el progresivo incumplimiento de los acuerdos de Tomar. Su intensa relación con España se refleja también en el plano literario, ya que Tovar debe mucho a la poesía de Góngora y, en particular, a las Soledades.
Keywords: Luis de Tovar, Góngora, épica culta, Monarquía Dual, Madrid, identidad portuguesa.
Versos para un pequeño príncipe de Portugal
Authors: Álvarez-Cifuentes Pedro 
Published: November 2022

El nacimiento del futuro D. Pedro II de Portugal, el último hijo de los reyes D. João IV de Bragança y D.ª Luisa de Guzmán, fue festejado con grandes fastos y celebraciones. En el contexto jubiloso de la Restauração de la independencia de Portugal, los poetas de la corte lisboeta se esmeraron en ensalzar a la Casa de Bragança como nueva dinastía real, tanto en portugués como en otras lenguas. Se propone una contextualización y análisis de las publicaciones poéticas que aparecieron en 1648 con motivo del nacimiento del nuevo príncipe: el Jardim de Fanimor de Diogo Ferreira Figueiroa, el Aplauso Ulysiponense de Manuel Gomes Serrano, y los Varios versos ao felix nacimento do serenissimo infante Dom Pedro Manoel de la Academia dos Generosos.
Keywords: Restauração, poesía panegírica, Academia dos Generosos, Casa de Bragança, D. Pedro II.
Portugueses ilustres en los paratextos de Lope de Vega: las dedicatorias a Ferreira y Sampayo (1620), Rodrigo Mascareñas (1623) y Faria y Sousa (1625)
Authors: García Aguilar Ignacio 
Published: November 2022

En el período 1620-1625 Lope de Vega introduce y desarrolla una innovación paratextual en sus recopilaciones de comedias adocenadas, consistente en la inclusión de una dedicatoria al frente de cada una de las doce obras teatrales compendiadas en sus volúmenes. Con esta multiplicación de los dedicatarios persigue obtener ventajosos réditos por parte de importantes agentes del sistema literario de su época. Del casi centenar de dedicatorias teatrales que redactó durante este lustro, únicamente tres se dirigen a ingenios portugueses. El presente trabajo examina esos paratextos y los interpreta atendiendo a las estrategias que desarrolla el Lope de senecute en el marco de su complejo contexto histórico-literario.
Keywords: Lope de Vega, dedicatorias, paratextos, Partes de comedias.
STUDI PERBANDINGAN PERLAKUAN BAHAN BAKU DAN METODE DISTILASI TERHADAP RENDEMEN DAN KUALITAS MINYAK ATSIRI SEREH DAPUR (Cymbopogon citratus)
Authors: - Slamet , - Supranto , - Riyanto 
Published: November 2022

Indonesia is rich in plant biodiversity. Indonesia volatile oil development efforts through increased development of one plant of lemon grass, which is one of the essential oil producing plants known as Cymbopogon citratus. Lemongrass essential oil in the chemical industry used as raw materials in the manufacture of cosmetics, perfume, deodorant, deodorant soap, floor cleaners and detergents.The purpose of this study was to determine the highest yield of lemongrass essential oil distillation using the method of water distillation, water-steam, and steam to the treatment of intact leaves and chopped leaves and know the quality of essential oil of lemongrass with the treatment of raw materials and different methods of distillation, the design used by two factors: variation in the treatment of raw material (whole leaves and chopped leaves) and the distillation process variation (distilled water (boiled), water-steam distillation and steam distillation. Data obtained from the analysis of yield, specific gravity, refractive index, and oil content of the compound citral essential (lemongrass oil).This study uses three methods of distillation, the distillation of water, water-steam distillation and steam distillation is carried out on samples of intact leaves and chopped leaves of fresh lemongrass. The results yield calculation and testing of physics and chemistry, as well as in the method of analysis SPSS One-Sample Test Statistics for the lemongrass essential oil products.Based on the results of research on the treatment of raw materials and distillation methods can be concluded that the treatment of raw materials lemongrass intact leaves with water distillation method (boiled) at both the content yield 0.52%, 71.84% citral, specific gravity 0.8967 g/mL, and the refractive index of 1.4905. It is appropriate to mention that SNI 06-39-53-1995 yield 0.3%, the specific gravity of 0.8731 g/mL, and the refractive index of 1.4586. But the content of citral not meet SNI standards are 76.1%, but according to Guenther (2006) which states citral content of between 65% to 85%.
PREDICTION OF WELL BEHAVIOR USING WELL DELIVERABILITY ANALYSIS
Authors: Asmorowati Dewi , Wildan M. Waziz , - Khasani 
Published: November 2022

In operating geothermal field, the thing to note is the sustainable production as well as problems that affect it. The problem that often occurs in the geothermal field is scale, corrosion and mechanical problems. One technique that can be used to predict the problems that occur around the bottom hole to the surface is using the well deliverability analysis method. Analysis is done by data and curve interpretation of deliverability curve based on Grant experiment. This study take data from several wells in two Geothermal Field in Indonesia. From the analysis, well A, D and F show production decline The deliverability curve of well A shows the production decline for about 60 – 85%, it is caused by moving of the flashing point, it shows from the increasing of dryness value from 7-14% in 1997 become 13-15% in 2010. The deliverability curve of well D shows the production decline for about 50%, it is caused by declining of reservoir pressure that can be seen from the decreasing of feed zone pressure in 1997 is 27 bar and in 2010 is 20 bar. The deliverability curve of well F shows the production decline for about 29%, it is caused by moving of the flashing point.
SIMULATION MODEL DEVELOPMENT FOR FIRE WATER PIPING NETWORK WITH NEWTON-RAPHSON ITERATION
Authors: Patarru Ari Ariangga Orranius Putra , Waluyo Joko , Masruroh Nur Aini 
Published: November 2022

The oil and gas industry is an industry that possesses various risks. The most significant risk in this sector is fire. To support the oil and gas production activities, it is necessary to install permanent and non-permanent fire extinguishers to prevent and deal with fire accidents. The firewater network system has a role in supplying flow rates with a certain pressure to protect the production process in a fire. The flow rate and pressure must be able to preserve the process area. Therefore the performance of firewater network system must be monitored. Over time, the performance degradation of the firewater network system is unavoidable. This decrease is due to scaling or leak minor at pipe and the decreasing performance of the diesel fire pump.This research aims to create a model of simulation fire water network system using newton-raphson iteration. The simulation model that is formed will be used to vary the flow rate against pressure. Based on iteration show the flow rate at platform 4 is 198.9 m3/h. The discharge variation is carried out to see the pressure on platform 4, the variation of the discharge of 2,000 m3/h gives a pressure of 150.45 psig, the variation of the discharge of 1,500 m3/h gives a pressure of 130.85 psig, and the variation of the discharge of 500 m3/h gives a pressure of 24.26 psig. The results of the discharge variation are used to see the performance of the fire water network system. Performance with a discharge of 2,000 m3/h decreased by 9.74%, and performance with a discharge of 1,000 m3/h decreased by 8.81%.
Personalization and Inclusion in Latvian Advertising as a Result of Multicultural Processes
Authors: Ločmele Gunta 
Published: November 2022

This paper examines how multicultural processes contribute to the formation of the features of Latvian advertising language – personalization and inclusion. The imperative mood, the singular and the plural form of the 2nd person pronoun are considered as means of making the advertising message more personal. Strategies for including the audience in translated advertisements are discussed. Understanding of these features is of major importance for Latvian translators who deal with trans-linguistic, trans-market, and trans-cultural transfer of promotional and advertising texts.
Deficits and Disparities in Early Uptake of Glucagon-Like Peptide 1 Receptor Agonists and SGLT2i Among Medicare-Insured Adults Following a New Diagnosis of Cardiovascular Disease or Heart Failure
Authors: Cromer Sara J. , Lauffenburger Julie C. , Levin Raisa , Patorno Elisabetta 
Published: November 2022

OBJECTIVE
To examine the association of race/ethnicity and socioeconomic deprivation with initiation of guideline-recommended diabetes medications with cardiovascular benefit (glucagon-like peptide 1 receptor agonists [GLP1-RA] and sodium–glucose cotransporter 2 inhibitors [SGLT2i]) among older adults with type 2 diabetes (T2D) and either incident atherosclerotic cardiovascular disease (ASCVD) or congestive heart failure (CHF).

RESEARCH DESIGN AND METHODS
Using Medicare data (2016–2019), we identified 4,057,725 individuals age &gt;65 years with T2D and either incident ASCVD or CHF. We estimated incidence rates and hazard ratios (HR) of GLP1-RA or SGLT2i initiation within 180 days by race/ethnicity and zip code–level Social Deprivation Index (SDI) using adjusted Cox proportional hazards models.

RESULTS
Incidence rates of GLP1-RA or SGLT2i initiation increased over time but remained low (&lt;0.6 initiations per 100 person-months) in all years studied. Medication initiation was less common among those of Black or other race/ethnicity (HR 0.81 [95% CI 0.79–0.84] and HR 0.84 [95% CI 0.75–0.95], respectively) and decreased with increasing SDI (HR 0.96 [95% CI 0.96–0.97]). Initiation was higher in ASCVD than CHF (0.35 vs. 0.135 initiations per 100 person-months). Moderate (e.g., nephropathy, nonalcoholic fatty liver disease) but not severe (e.g., advanced chronic kidney disease, cirrhosis) comorbidities were associated with higher probability of medication initiation.

CONCLUSIONS
Among older adults with T2D and either ASCVD or CHF, initiation of GLP1-RA or SGLT2i was low, suggesting a substantial deficit in delivery of guideline-recommended care or treatment barriers. Individuals of Black and other race/ethnicity and those with higher area-level socioeconomic deprivation were less likely to initiate these medications.
Sleep Duration and Risks of Incident Cardiovascular Disease and Mortality Among People With Type 2 Diabetes
Authors: Han Han , Wang Ying , Li Tongtong , Feng Chengwu , Kaliszewski Catherine , Su Yang , Wu Yinfan , Zhou Jian , Wang Liang , Zong Geng 
Published: November 2022

OBJECTIVE
People with type 2 diabetes may have insufficient or prolonged sleep that could accelerate cardiovascular disease (CVD) onset, but existing evidence from prospective studies has been limited. We examined the association of sleep duration with CVD incidence and mortality in this high-risk population.

RESEARCH DESIGN AND METHODS
This prospective study included 18,876 participants with type 2 diabetes in the UK Biobank who were free of CVD and cancer at baseline. Habitual sleep duration was obtained using a baseline questionnaire. Cox proportional hazards regression models were used to examine the association between sleep duration and CVD events.

RESULTS
During an average follow-up of 11.0–12.0 years, we documented 2,570 incident cases of atherosclerotic cardiovascular disease (ASCVD) and 598 CVD deaths. Compared with sleeping for 7 h/day, the multivariable-adjusted hazard ratios of ≤5 and ≥10 h/day were 1.26 (95% CI 1.08, 1.48) and 1.41 (1.16, 1.70) for incident ASCVD, 1.22 (0.99, 1.50) and 1.16 (0.88, 1.52) for coronary artery disease, 1.70 (1.23, 2.35) and 2.08 (1.44, 3.01) for ischemic stroke, 1.02 (0.72, 1.44) and 1.45 (1.01, 2.10) for peripheral artery disease, and 1.42 (1.02, 1.97) and 1.85 (1.30, 2.64) for CVD mortality. Similar results were observed in most sensitivity analyses that aimed to address potential reverse causation and in the joint analyses of sleep duration and metabolic control or diabetes severity status.

CONCLUSIONS
Short and long sleep durations were independently associated with increased risks of CVD onset and death among people with type 2 diabetes.
Characteristics and Correlation Between Progesterone Receptors and The Use of Hormonal Contraceptive in Women with Meningioma in dr. Cipto Mangunkusumo National General Hospital
Authors: Widi Nugroho Setyo , Istianggoro Harris , Santoso Fabianto , Tandian David , Aman Renindra Ananda , Susanto Eka 
Published: November 2022

Meningiomas are the most common primary, intracranial and extra axial tumours, estimated for 30% of all intracranial tumors. The use of hormonal contraceptive is one of the risk factors for meningioma, but the studies still have controversial results. The purpose of this study is to describe the characteristics and to correlate between progesterone receptor and the use of hormonal contraceptive in women diagnosed with brain tumor meningioma. This is a cross-sectional study which collect data in dr. Cipto Mangunkusumo National General Hospital in the year 2017-2018. Patient data collection was obtained through the patient’s medical records, whereas the subjects are women with brain tumors meningioma who have undergone surgery. We found 72 women diagnosed with meningioma; however, only 54 subjects were included in this study. Immunohistochemistry staining were performed to all the 54 subjects and revealed that 53 subjects (98.15%) had positive progesterone receptors and only 1 subject was negative (1.85%). Of the 53 subjects with positive progesterone receptors, 48 subjects used hormonal contraceptive (90.57%), with 43 (89.58%) of them used 3 month injectable contraceptive. There is no correlation between progesterone receptors and the use of hormonal contraceptives in female patients with meningioma brain tumor (p value >0.999, Fisher Test).
Keywords: meningioma, hormonal contraception, progesterone receptor.

Karakteristik dan Korelasi antara Progesteron Reseptor dan Penggunaan Kontrasepsi Hormonal pada Perempuan dengan Meningioma di RSUPN Dr. Cipto Mangunkusumo
Abstrak
Meningioma adalah tumor intrakranial ekstraaksial primer terbanyak dengan perkiraan 30% dari seluruh tumor intrakranial. Penggunaan kontrasepsi hormonal diduga menjadi salah satu faktor risiko meningioma, namun hasil penelitian masih kontroversial. Tujuan penelitian ini adalah mengetahui karakteristik dan korelasi antara progesteron reseptor dan penggunaan kontrasepsi hormonal pada perempuan dengan meningioma. Studi potong lintang ini menggunakan data rekam medis RSUPN dr. Cipto Mangunkusumo pada tahun 2017-2018. Data pasien dikumpuikan melalui rekam medis dimana subyek adalah pasien meningioma intrakranial yang dilakukan operasi. Terdapat 72 perempuan yang didiagnosis meningioma, namun data yang dapat dianalisis adalah 54 subyek. Hasil pewarnaan imunohistokimia didapatkan 53 subyek (98,15%) memiliki reseptor progesteron positif. Dari kelompok reseptor progesteron yang positif, 48 subyek (90,57%) menggunakan kontrasepsi hormonal dengan mayoritas (89,58%) menggunakan kontrasepsi injeksi 3 bulan. Tidak didapatkan korelasi antara reseptor progesteron dengan penggunaan kontrasepsi hormonal pada perempuan dengan meningioma (nilai p >0,999, Uji Fisher).
Kata kunci: meningioma, kontrasepsi hormonal, reseptor progesteron