bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comprehensive Methodology to Support Decision-Making Towards Sustainability on Nanocomposite Materials in Additive Manufacturing Sector
Authors: Petrakli Foteini , Gkika Anastasia , Vlysidis Anestis , Karayannis Panagiotis , Koumoulos Elias 
Published: January 2022

Abstract
Innovative nanocomposite materials and resultant additive manufacturing products are necessary to be assessed for their carbon footprint towards top priorities of EU for plastics, including the European Green Deal principles and the Action Plan for Circular Economy. Life Cycle Assessment (LCA) is widely applied standardized methodology that aims to study potential environmental impacts of novel products. Nano-scale materials (NM) are usually dispersed in polymer to enhance their limited functional properties resulting in a spectrum of end-products for multiple applications. However, little information exists on their environmental impact. Within this context, this study presents a ‘cradle-to-gate plus end-of-life’ LCA approach, studying different types of 3D printing nanocomposite filaments across the supply chain. Three different types of polymer matrixes were examined: polyamide (PA), polypropylene (PP) and polylactic acid (PLA), additivated with three different types of nanomaterial additives: multiwall carbon nanotubes (MWCNTs), graphene oxide (GO) forms and graphene nanoplatelets (GNPs), considering lab-scale production. In addition, several different EoL scenarios have been examined for the materials. Finally, LCA findings are coupled with the performance (taken here as conductivity) of these new materials to assist the decision-making process for selecting efficient scenarios with the least environmental impact. The outputs of this examination enable identification of potential sustainability issues for novel nanocomposite materials at an early design stage, while also assisting in the definition of actions to mitigate such issues. Thus, LCA studies can generate knowledge on the environmental impacts of nano-enabled materials, while also serving as a valuable decision support tool towards optimizing material sustainability aspects.
SARS-CoV-2 Spike Protein Induces Cognitive Deficit and Anxiety-like Behavior in Mouse via Non-cell Autonomous Hippocampal Neuronal Death
Authors: Lee Sung Joong , Oh Jun Young , Cho Woo-Hyun , Ellane Barcelon , Kim Kwang Hwan , Hong Jinpyo 
Published: January 2022

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied by chronic neurological sequelae such as cognitive decline and mood disorder, but the underlying mechanisms have not yet been elucidated. In this study, we explored the possibility that the brain-infiltrating SARS-CoV-2 spike protein contributes to the development of neurological symptoms observed in COVID-19 patients. Our behavioral study showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse hippocampus induced cognitive deficit and anxiety-like behavior in vivo. These neurological symptoms were accompanied by neuronal cell death in the dorsal and ventral hippocampus as well as glial cell activation. Interestingly, the S1 protein did not directly induce hippocampal cell death in vitro. Rather, it exerted neurotoxicity via glial cell activation, partially through interleukin-1β induction. In conclusion, our data suggest a novel pathogenic mechanism for the COVID-19-associated neurological symptoms that involves glia activation and non-cell autonomous hippocampal neuronal death by the brain-infiltrating S1 protein.
Effects of Land Use Land Cover and Slope Gradients on Soil Fertility at Kori Sub-Watershed, East Wollega, Ethiopia
Authors: Bekana Begna Tesema , Gudeta Tolera Megersa , Chalchisa Fedhasa Benti 
Published: January 2022

Abstract
BackgroundThe complex nature of the relationship and interaction between LULC and slope gradients resulted in the decline of soil fertility parameters, which aggravate the reduction of sustainable productivity in Ethiopia in general and the study area in particular. This study was aimed to determine the effects of land use land cover and slope gradients on the physicochemical properties of soil in study area A total of 27 composite soil samples were collected from 0-20cm depth under three dominant adjacent LULC across three slope with three replications. The collected soil samples were analyzed for selected soil physicochemical properties. Two-way ANOVA was used to test the mean differences of the soil fertility parameters. ResultThe mean values of soil physicochemical parameters showed that, SOC, TN, AvP, CEC, exchangeable bases (Ca2+ Mg2+, K+, and Na+), PBS, and percentage of clay contents of cultivated land and steep slope gradient (15-30%) were low and significantly different at (P≤0.05) than forest and grad grassland of the same slope gradient.. The gentle slope (3-8%) gradients of the forest lands had the lowest BD and high TP as compared to the others.Conclusion﻿The overall soil fertility status of the steep slope gradient (15-30%) of cultivated lands is lower than others and cultivating the steep slope is the cause for productivity loss in the study sub-watershed. Therefore, proper land-use planning and the use of integrated soil fertility management strategy give better production and keep the soil fertility status to a better level.
Dapagliflozin Alleviates Myocardial Inflammation by Regulating the Macrophage Polarization and Stat3-related Pathways in Coxsackie Virus B3-induced Acute Viral Myocarditis
Authors: Yan Pengcheng , Song Xiaoning , Tran Joanne , Zhou Runfa , Cao Xinran , Zhao Gang , Yuan Haitao 
Published: January 2022

Abstract
Viral myocarditis (VMC), which is most prevalently caused by Coxsackievirus B3 (CVB3) infection, is a serious clinical condition characterized by cardiac inflammation. Dapagliflozin, a kind of sodium glucose co-transporters 2(SGLT-2) inhibitor, exhibited protective effects on plenty of inflammatory diseases, while its effect on viral myocarditis has not been studied. Recently we found the protective effect of dapagliflozin on VMC. After CVB3 infection, dapagliflozin were given orally to Balb/c male mice for 8 days and then the severity of myocarditis was assessed. Our results indicated that dapagliflozin significantly alleviated the severity of viral myocarditis, elevated the survival rate, and ameliorated cardiac function. Besides, dapagliflozin can decrease the level of proinflammatory cytokines included IL-1β, IL-6, TNF-α. Furthermore, dapagliflozin can inhibit macrophages differentiate to classically activated macrophages (M1) in cardiac tissue and activate the Stat3 signal pathway which is reported to promote polarization of the alternatively activated macrophage (M2). In conclusion, our study demonstrates that dapagliflozin alleviates myocardial inflammation by regulating the macrophage polarization and Stat3-related pathways in coxsackie virus B3-induced acute viral myocarditis.
Optimization of extraction techniques for processing and utilization of Cyperus Dichrostachus A. Rich Plant as fiber
Authors: Gelaw BELETE BAYE , Tesfaye Tamrat 
Published: January 2022

Abstract
The Textile industry is an important contributor to the GDP of countries worldwide. Both natural and synthetic fibers are the main raw materials for this sector. Environmental concerns, depletion of non-renewable resources, the high price of oil and limited oil reserves with consumer demand is driving research into cheap, biodegradable, sustainable, renewable and abundantly available green materials. Natural fibers are of the good substitute sources for swapping synthetic fibers and reinforcing polymer matrices because of their contributions in maintaining of ecology, nature of disposal, low energy requirement for processing and sustainability. The current research emphases on evaluating and determining the best extraction methods to process and treat cyperus Dichrostachus A.Rich plant in order to make the fiber suitable for variety of applications. Cyperus Dichrostachus A.Rich plant was treated with two conditions (cold and warm conditions) using statistically planned tests. Process conditions were optimised using central composite design methodology with the experimental design. Under optimised conditions, the strength and fiber yield of CDA fibers were significantly compared. The strength and fiber yield of the fiber was at maximized with optimized conditions and use for valorisation applications.
Prevalence and Associated Risk Factors of Entamoeba Histolytica Infection Among Schoolchildren From Three Primary Schools In Arsi Town, West Zone, Ethiopia
Authors: Roro Geribe Bushura , Hajare Sunil Tulshiram , Al-Hazim Awdah M , Kuddus Mohammed , Eriso Feleke 
Published: January 2022

Abstract
Entamoeba histolytica is one of the major pathogenic intestinal parasites and is amongst the leading causes of diarrheal illness in children. Around 500 million people are infected worldwide, while 75,000 die of the disease annually. E. histolytica is associated with moderate to severe diarrhoea and increased mortality among children in African countries and negatively affects child growth and development. Malnutrition is also an important contributor to the prevalence of E. histolytica in Ethiopia. It is mostly associated with poor hygiene, poverty, illiteracy, lack of access to potable water, and a hot, humid tropical climate. Thus, the present investigation was aimed to assess the prevalence rate and associated factors of E. histolytica among schoolchildren in Arsi Town, West Zone, Oromia Regional State, Ethiopia. A cross-sectional study was conducted from February 1st to May 1st, 2020. A total of 334 students were selected from three governmental elementary schools in the west zone using a systematic sampling method. A structured questionnaire was adopted to identify environmental, socio-demographic, and behavioral factors. Microscopically positive samples for E. histolytica cysts were further characterised using an E. histolytica II antigen detection kit. The statistical analysis of the data was done using SPSS software. A univariate and multivariate logistic regression analysis was done. P value < 0.05 was considered statistically significant. The overall prevalence of E. histolytica was 19.8%. Hand washing habits before eating [AOR = 0.32; 95% CI (0.12, 0.84)], hand washing habits after defecation [AOR = 0.396; 95% CI (0.165, 0.946)], and ameba awareness [AOR = 0.35; 95% CI (0.142, 0.889)] were factors associated with parasite prevalence.
Trace elements characterization of soils and rocks in Agricultural areas of Labunwa, Near Idanre, Southwestern Nigeria
Authors: Asowata Iyobosa Timothy , Adisa A.L. 
Published: January 2022

Abstract
Trace elements (TE) concentrations of subsoil and the underlying parent rocks of Labunwa – Odele area were determined in other to ascertain the enrichment level, distribution and sources of these TEs in the subsoil in the study area. Twenty-one (21) subsoil (at depth of 30 -100 cm) and thirteen (13) rock samples were collected, pulverised and digested using aqua regia for soil samples and near total digestion of HClO4, HF, HCl and HNO3of different proportions for the rocks. The samples were analysed using Inductively Coupled Plasma- Mass Spectrometry, (ICP-MS). The mean TE concentrations in ppm for subsoil showed Cu (40.0), Pb, (24.2), Zn (56.3), As (0.9) and U (2.7) among other elements as against the mean concentrations of granite gneiss (GGN) with Cu (22.9), Pb (61.4), Zn (64.6), As (1.0), U (2.6) and Pegmatite, (PGM) Cu(128.4), Pb(17.0), Zn(108.8), As (1.1), U (1.3) among other TEs. The relatively low concentrations of the TEs in the subsoil compared to the underlying parent rocks suggests that TEs in the subsoil may have been influenced by geogenic factors, such as weathering of the underlying rocks. TEs source apportionments in the subsoil using Bivariant plots, correlation coefficient, Bi-polar and dendogram analyses showed that these TEs are essentially from the underlying GGN and PGM in the area. Pollution status indices, I-geo, Contamination factor and PLI showed that the study area is practically unpolluted. This suggests that locations with relatively higher concentrations of some TEs are probably due to mineralisation and since most of the subsoil TEs are significantly lower in concentrations compared to the underlying bedrock, the area is safe for agricultural activities.
Hyperbolic Plasmons Propagate through a Nodal Metal
Authors: Shao Yinming , Sternbach Aaron , Kim Brian , Rikhter Andrey , Xu Xinyi , De Giovannini Umberto , Jing Ran , Chae Sang Hoon , Sun Zhiyuan , Zhu Yang Lin , Mao Zhiqiang , Hone James , Queiroz Raquel , Millis Andrew , Schuck P. , Rubio Angel , Fogler Michael , Basov Dimitri 
Published: January 2022

Abstract
Metals are canonical plasmonic media at infrared and optical wavelengths allowing one to guide and manipulate light at sub-diffractional length scales. A special form of optical waveguiding is offered by highly anisotropic crystals revealing different signs of the dielectric function along orthogonal directions. These latter types of media are classified as hyperbolic and many crystalline insulators, semiconductors and artificial metal-based metamaterials belong to that class. Layered anisotropic metals are also anticipated to support hyperbolic waveguiding. Yet this behavior remains elusive primarily because interband processes introduce extreme losses and arrest light propagation. Here, we report on the observation of propagating hyperbolic waves in a prototypical layered nodal-line semimetal ZrSiSe. The unique electronic structure with touching energy bands at nodal points/lines suppresses losses and enables a hyperbolic regime at the telecommunications frequencies. The observed waveguiding in metallic ZrSiSe is a product of polaritonic hybridization between near-infrared light and long-lived nodal-line plasmons. By mapping the energy-momentum dispersion of the nodal-line hyperbolic modes in ZrSiSe we inquired into the role of additional screening associated with the surface states.
Control and Prevent Land Subsidence Caused by Foundation Pit Dewatering in a Coastal Lowland Mega City: Indicator Definition, Numerical Simulation and Regression Analysis
Authors: Wang Jianxiu , Yang Tianliang , Wang Guotao , Liu Xiaotian , Xu Na , Stoumather Esther , Yin Yao , Wang Hanmei , Yan Xuexin , Huang Xinlei 
Published: January 2022

Abstract
Coastal mega cities are often commercial centers because of convenient traffic. Safe elevation above sea level is vital for their sustainable development. Global climate change and sea level rising increase flood risk especially in the lowland subsidence area. Shanghai of China was selected as research background. Although groundwater exploitation had been strictly restrained to control land subsidence and reserve safe elevation, lowering groundwater level during underground excavation cannot be avoided. Foundation pit dewatering (FPD) was intensively performed in underground exploitation during urbanization and city renewal. The FPD settlement accelerated land subsidence. Controlling FPD subsidence was urgent. Normally, the maximum horizontal influence radius of foundation pit excavation was less than three times excavation depth (H), and the 3H settlement was only caused by the FPD. The 3H maximum settlement was defined as the evaluating indicator of FPD land subsidence, and the corresponding 3H drawdown was defined as the control indicator of land subsidence. The FPD conceptual models were established on the basis of estimation and investigation of foundation pit information, including pit area, pit shape, pit depth, and curtain depth. Numerical models were established and a total of 5650 FPD numerical simulations were performed to investigate the land subsidence and FPD drawdown. Multi-factor regression analysis was conducted to obtain relations between land subsidence and FPD drawdown. Regression models were established between the 3H drawdown and the shape, area, depth, and curtain depth of foundation pit on the basis of the numerical simulations. A typical example introduced to verify the regression models. The regression models were used to manage the FPD land subsidence by controlling the 3H FPD drawdown. The results can provide reference for the land subsidence control in a coastal lowland city.
Associations between sarcopenia with asthmatic prevalence, lung function and comorbidity
Authors: Hu Zhigang , Tian Yufeng , Song Xinyu , Zeng Fanjun , Yang Ailan 
Published: January 2022

Abstract
Background

Sarcopenia was listed as a treatment trait in behavioral/risk factors of severe asthma, but studies between asthma and sarcopenia were scant. This study plans to determine the associations between sarcopenia with asthmatic prevalence, symptoms, lung function and comorbidity.
Methods

15404 individuals from the China Health and Retirement Longitudinal Study(CHARLS) and 10263 individuals from Study on global AGEing and adult health(SAGE) in China were included in this study. Four components of this study were respectively used to assess bidirectional association in the prevalence between sarcopenia with asthma, and estimate the relationships between sarcopenia with asthmatic symptoms, lung function and comorbidity via generalized additive models. The 10-item Center for Epidemiological Studies–Depression Scale≥12 scores was classified as depression in CHARLS.
Results

In CHARLS and SAGE, the prevalence of sarcopenia in asthmatics was higher than those without asthma. Asthmatics with sarcopenia had a significantly increased prevalence of severe shortness of breath(sarcopenia yes vs no, adjusted OR=3.71, 95%CI: 1.43-9.60) and airway obstruction in SAGE(sarcopenia yes vs no, adjusted OR=6.82, 95%CI: 2.54-18.34) and an obvious reduction of PEF in CHARLS and SAGE(sarcopenia yes vs no, adjusted RR=0.86, 95%CI: 0.82-0.91) compared to asthmatics without sacropenia. The presence of sarcopenia was positively associated with the prevalence of chronic obstructive pulmonary disease(sarcopenia yes vs no, adjusted OR=5.76, 95%CI:2.01-16.5) and depression(sarcopenia yes vs no, adjusted OR=1.87, 95%CI:1.11-3.14) in asthmatics.
Conclusions

Our findings indicated that sarcopenia partakes in the development of asthma by affecting lung function and comorbidity and maybe considered a treatable trait of asthma management.
Research on lncRNA Related to Drought Resistance of Shanlan Upland Rice
Authors: Yang Xinsen , Liu Caiyue , Niu Xiaoling , Wang Liu , Li Laiyi , Yuan Qianhua , Pei Xinwu 
Published: January 2022

Abstract
Background

Drought has become the major abiotic stress that causes losses in rice yields and consequently is one of the main environmental factors threatening food security. Long non-coding RNA (lncRNA) is known to play an important role in plant response to drought stress, while the mechanisms of competing endogenous RNA (ceRNA) in drought resistance in upland rice have been rarely reported.
Results

In our study, a total of 191 lncRNAs, 2115 mRNAs and 32 miRNAs (microRNAs) were found by strand-specific sequencing and small RNA sequencing to be differentially expressed in drought-stressed rice. Functional analysis of results indicate that they play important roles in hormone signal transduction, chlorophyll synthesis, protein synthesis and other pathways. Construction of a ceRNA network revealed that MSTRG.28732.3 may interact with miR171 in the chlorophyll biosynthesis pathway and affect the ability of plants to withstand drought stress by regulating Os02g0662700, Os02g0663100 and Os06g0105350. The accuracy of the regulatory network was verified by qRT-PCR.
Conclusion

Our results provide a theoretical basis for future studies on the potential function of lncRNA in plant drought resistance, and they provide new genetic resources for drought-resistant rice breeding.
Halogenated Greenhouse Gases Made Global Warming Primarily
Authors: Lu Qing-Bin 
Published: January 2022

Abstract
Time-series observations of global lower stratospheric temperature (GLST), global land surface air temperature (LSAT), global mean surface temperature (GMST), sea ice extent (SIE) and snow cover extent (SCE), together with observations reported in Paper I, combined with theoretical calculations of GLSTs and GMSTs, have provided strong evidence that ozone depletion and global climate changes are dominantly caused by human-made halogen-containing ozone-depleting substances (ODSs) and greenhouse gases (GHGs) respectively. Both GLST and SCE have become constant since the mid-1990s and GMST/LSAT has reached a peak since the mid-2000s, while regional continued warmings at the Arctic coasts (particularly Russia and Alaska) in winter and spring and at some areas of Antarctica are observed and can be well explained by a sea-ice-loss warming amplification mechanism. The calculated GMSTs by the parameter-free warming theory of halogenated GHGs show an excellent agreement with the observed GMSTs after the natural El Niño southern oscillation (ENSO) and volcanic effects are removed. These results provide a convincing mechanism of global climate change and will make profound changes in our understanding of atmospheric processes. This study also emphasizes the critical importance of continued international efforts in phasing out all anthropogenic halogenated ODSs and GHGs.
An Evaluation of the Enhanced Cognitive-Behavioral Model of Bulimia Nervosa in Iranian Student Women
Authors: Moloodi Reza , Mahmoodi Maryam , Mohammadpour Zinat , Naghashian Farnush , Alasti Haniye , babai Zahra , Saleh Zeinab , Ahmadi Paria , Barani Masoumeh 
Published: January 2022

Abstract
Background: The original and enhanced cognitive-behavioral model of bulimia nervosa model has yet to be evaluated among women of Eastern socities. Thus, the current study aimed to investigate the validity of original and enhanced version of CB-BN model in a sample of Iranian student women. Methods: Five hundred sixteen student women completed a bttery of questionnaires. Results: Fit indices idicated that both the original and enhanced models provided a good fit to the data. In the original model, overvaluation of shape and weight and associated with dietary restraint and Binge Eating. Binge eating and dietary restraint correlated with purging. In the enhanced model, significant path was observed between self-esteem and overvaluation of shape and weight; clinical perfectionism and overvaluation of shape and weight; Overvaluation of shape and weight and dietary restraint; Overvaluation of shape and weight and binge eating; binge eating and purging; dietary restraint and purging; and interpersonal problems and binge eating. Discussion: Altough, the present study verifyes some aspects of CB-BN models in Irnaian women students, some key relationships in the model were not confirmed, including the relationship between dietary restraint and binge eating.