bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Flexible, Highly Accurate, and Stable Pressure Sensor with Anti‐Interference from Temperature, Sweat, and Humidity
Authors: Ma Jun , Liu Qi , Yang Liyan , Li Mufang , Liu Qiongzhen , Zhong Weibing , Lu Ying , Wang Yuedan , Liu Xue , Wang Dong 
Published: December 2022

AbstractThe highly accurate and stable pressure sensors with anti‐interference from varying sensing environments (temperature and humidity) are essential and a challenge in practical applications. However, real‐time electrical resistance fluctuation or even sensing inaccuracy are widely existed due to the sensibility of conductive materials towards varying temperatures, humidity, and sweat circumstance. Here, for the first time, the hydrophobic, non‐fluoride, titanium dioxide nanoparticle (TiO2‐ODI) modified carbon nanotube (CNT)/carbon black (CB) pressure sensors are introduced to achieve anti‐interference from temperature, droplets, and humidity. The sensors with a near‐zero temperature coefficient of resistance (near‐ZTC) effect (≈ −10 to 70 °C). The anti‐interference from moisture benefits from the effective isolation effect of the hydrophobic TiO2‐ODI layer. Meanwhile, the TiO2‐ODI/CNT/CB pressure sensors obtain a favorable sensitivity of 1.57 kPa−1, a fast response time of 20 ms, a negligible hysteresis ratio of 1.9%, prominent air permeability, and a facile scalable strategy. Hence, the TiO2‐ODI/CNT/CB pressure sensors are feasible for accurately and stably sensing under varying sensing environments by efficiently suppressing interferences from varying temperatures, high humidity, and sweat.
Fiber Optical Detection of Lithium Plating at Graphite Anodes
Authors: Hedman Jonas , Mogensen Ronnie , Younesi Reza , Björefors Fredrik 
Published: December 2022

AbstractAvoiding the plating of metallic lithium on the graphite anode in lithium‐ion batteries, potentially leading to aging and the formation of dendrites is critical for long term and safe operation of the cells. In this contribution, in operando detection of lithium plating via a fiber optical sensor placed at the surface of a graphite electrode is demonstrated. The detection is based on the modulation of light at the sensing region, which is in direct contact with the graphite particles. This is first demonstrated by the intentional deposition of lithium on a copper electrode, followed by experiments with graphite electrodes in pouch cells where plating is initiated both as a result of over‐lithiation and excessive cycling rates. The plating resulted in a significant loss of light from the fiber, and the findings correlated well with previous experiments on the detection of sodium plating. The modulated light is also found to correlate well with the graphite staging via changes in the optical properties of the graphite during slow (de)intercalation of lithium ions. In a practical application, the fiber optical sensor may provide a battery management system (BMS) with input to optimize the charging procedure or to warn for cell failure.
Increasing Electrode Work Function Using a Natural Molecule
Authors: Akaike Kouki , Hosokai Takuya , Ono Yutaro , Tsuruta Ryohei , Yamada Yoichi 
Published: December 2022

AbstractProviding sustainability to organic electronics is highly demanded to reduce the negative impact of organic devices on environments and human health upon their disposal. To attain biodegradability and biocompatibility of the electronic devices, utilization of the natural molecules for the device constituents is essential. In this study, it is reported that the adsorption of caffeic acid (CfA), a polar phenylpropanoid that plants bio‐synthesize, universally increases work functions (WFs) of practical electrodes and organic films. Either vacuum‐depositing or spin‐casting CfA films on the electrode materials form a dipole layer with the negative charges on the carboxyl group exposed to the outermost surface. The preferential adsorption of the catechol moiety of CfA onto substrate surfaces drives the molecular orientation, leading to the WF increase up to 0.7 eV. As a consequence, the single‐layer devices with the CfA interlayer facilitate the hole injection in forward bias by a factor of 101–102, which validates the usability of the natural molecule for organic electronics.
Logic Gates of Terahertz Spoof Surface Plasmons
Authors: Gao Xinxin , Chen Bao Jie , Shum Kam‐Man , Zhang Qing Le , Ma Qian , Cui Wen Yi , Cui Tie Jun , Chan Chi Hou 
Published: December 2022

AbstractSpoof surface plasmon polariton (SSPP) interconnects have great potential for the next‐generation wireless communications and terahertz (THz) integrated circuits. SSPP logic gates are reported to meet the above development requirements. However, the reported SSPP logic gates consist of 3D domino waveguide structure and conversion structure with a funnel‐shaped metasurface; and hence, suffer from the size limit of the compact on‐chip integrations. To explore a more compact and flexible design, a series of logic gates in the planar THz SSPP platform, including OR, AND, XOR, NOT, and NAND gates, is experimentally demonstrated. Owing to the flexible dispersion behaviors, different phase differences between inputs can be controlled by manipulating the SSPP waveguide structure, such as the SSPP Mach–Zehnder interferometer, thereby realizing various THz SSPP logic gates, which will enable powerful potential in large‐scale on‐chip systems, future wireless communications, and intelligent computing.
Light Emission from Low‐Dimensional Pb‐Free Perovskite‐Related Metal Halide Nanocrystals
Authors: Ray Aniruddha , De Trizio Luca , Zito Juliette , Infante Ivan , Manna Liberato , Abdelhady Ahmed L. 
Published: December 2022

AbstractIn recent years remarkable progress has been made on developing low‐dimensional perovskite‐related materials. In particular, with the aim of going toward compounds with low toxicity, various low‐dimensional metal halide nanocrystals have been synthesized and investigated. These nanocrystalline compounds crystallize in a plethora of structures and dimensionalities, in many cases with exciting optical properties. Thanks to their photoluminescence emission, which is typically broad and largely Stokes‐shifted, such nanocrystals can find applications in indoor lighting, scintillators and luminescent solar concentrators. In this review, recent developments leading to the improvement/management of light emission from such low‐dimensional metal halide nanocrystals are highlighted and the possible origin of their light emission is discussed. Furthermore, parallels with their bulk counterparts are drawn and an outlook on what is still worth exploring/studying in this field of research is provided.
Direct Synthesis of Indolines via Cyclization of Tertiary Aryl Amines with Iodonium Ylides under Sole Visible Light Irradiation
Authors: Zhao Yan‐Rui , Li Lei , Xuan Jun 
Published: December 2022

AbstractHerein we reported a direct synthesis series of indolines through cyclization of tertiary aryl amines with iodonium ylides. This cyclization reaction occurred under sole visible‐light irradiation at room temperature without the addition of any photocatalysts and additives. Preliminary mechanism studies revealed that an electron donor‐acceptor (EDA) complex between iodonium ylides and tertiary aryl amines should be formed during the reaction.magnified image
Smart Clothing with Built‐In Soft Sensing Network for Measuring Temporal and Spatial Distribution of Pressure under Impact Scenarios
Authors: Wang Fei , Zhu Bo , Shu Lin , Li Ying , Lai Xinghua , Ma Lingchen , Ji Peijun , Zhou Qing , Yu Tongxi , Tao Xiaoming 
Published: December 2022

AbstractNowadays, the need for protective devices at man–machine interfaces is increasing in the fields of traffic, sports, construction, and military, etc. Dynamic pressure sensing technology with wide measuring range, high sensitivity, softness, and fast response is crucial for evaluation and optimization of the personal protective equipment under impact scenarios. However, current sensors hardly possess all the aforesaid required characteristics. For the first time, this article reports the evaluation and application of an innovative soft pressure sensor with modulus of 2 MPa, maximum pressure of 8 MPa, and over 500‐Hz frequency. A theoretical model, taking strain rate into consideration, is established to characterize the dynamic sensing behavior. A sensing network in the form of smart clothing is developed and used in a sled crash test, which is a standard approach to evaluate the safety of automobiles in collisions. The pressure distribution over the dummy's surface during the crash is acquired in real‐time, and compared with numerical simulations. This study is important to the study of occupant injury and crashworthiness design for vehicles, and it will benefit the automotive industry. With the built‐in sensing network, the smart clothing has promising applications in the pressure mapping of 3D flexible man–machine interface under impact scenarios.
Effects of timing and nitrogen fertilizer application rates on maize yield components and yield in eastern Ethiopia
Authors: Mosisa Waktole , Dechassa Nigussie , Kibret Kibebew , Zeleke Habtamu , Bekeko Zelalem 
Published: December 2022

AbstractMaize (Zea mays L.) is an important food security crop in Ethiopia. However, low soil fertility and the use of haphazard nitrogen (N) fertilizer with little attention to the rate and timing of N application constrain productivity. Therefore, field experiments were conducted during the 2019 and 2020 cropping seasons to investigate the response of maize to different N application rates and timings. The treatments consisted of six N fertilizer rates (0, 23, 46, 69, 92, and 115 kg N ha−1) and four application timings (all at vegetative stages; one‐half at sowing + one‐half at vegetative stages; one‐third at sowing + one‐third at vegetative stages + one‐third at tasseling; one‐fourth at sowing + two‐fourths at vegetative stages + one‐fourth at tasseling). The experiments were a randomized block design in a factorial arrangement with three replications. The results of the study revealed that ears per plant, ear length, grains per row, grains per ear, stover, and grain yield were significantly (p ≤ .001) influenced by the interaction effects of N application rates and timings. The highest stover (9.99 t ha−1) and grain yield (9.41 t ha−1) were obtained from the application of 92 kg N ha−1 in three split applications of one‐fourth at sowing, one‐half at vegetative stages, and one‐fourth at tasseling. Therefore, it is concluded that 92 kg N ha−1 in three split applications of one‐fourth at sowing, two‐fourths at vegetative stages, and one‐fourth at tasseling was found to be the most economical in the study area.
Regional technical efficiency rankings and their determinants in the Irish dairy industry: A stochastic meta‐frontier analysis
Authors: Cele Lungelo P. , Hennessy Thia , Thorne Fiona 
Published: December 2022

AbstractThe paper aims to evaluate regional farm efficiency rankings for Ireland which seeks to be a leader in the global dairy industry. It conducts a within‐country analysis based on technical and scale efficiency of dairy farms to explore how regional constraints imposed by the milk quota may have affected Ireland's regional farm efficiency levels. The stochastic meta‐frontier approach is adopted because of its usefulness in comparing regional technical efficiencies. The findings suggest that policies aiming to promote labor and soil quality improvement in the East region, and that relate to discussion groups in the South region, in addition to management of herd size, would be useful for improving efficiency postquota. Moreover, some farms expanded beyond their optimal scale leading to a reduction in efficiency levels and this points to the need to tailor farm advice and promote caution and prudence in farm expansion decisions, especially in a region like South West. [EconLit Citations: D22, D24, L25, Q1, R1, R58].
Five Years of ChemRxiv: Where We Are and Where We Go From Here**
Authors: Mudrak Benjamin , Bosshart Sara , Koch Wolfram , Leung Allison , Minton Donna , Sawamoto Mitsuo , Tegen Sarah 
Published: December 2022

AbstractChemRxiv was launched on August 15, 2017 to provide researchers in chemistry and related fields a home for the immediate sharing of their latest research. In the past five years, ChemRxiv has grown into the premier preprint server for the chemical sciences, with a global audience and a wide array of scholarly content that helps advance science more rapidly. On the service's fifth anniversary, we would like to reflect on the past five years and take a look at what is next for ChemRxiv.
PD‐L1 Aptamer‐Functionalized Metal–Organic Framework Nanoparticles for Robust Photo‐Immunotherapy against Cancer with Enhanced Safety
Authors: Zhang Jingfang , Li Wenzhe , Qi Yafei , Wang Guorong , Li Lele , Jin Zhengyu , Tian Jie , Du Yang 
Published: December 2022

AbstractImmune checkpoint blockade has become a paradigm‐shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti‐PD‐L1 antibody (α‐PD‐L1), often shows unsatisfactory immune responses and lead to severe immune‐related adverse effects (irAEs). Herein, we develop a PD‐L1 aptamer‐based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal–organic framework nanoparticle core and a dense shell of aptPD‐L1 (denoted as M@O‐A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O‐A shows scarcely any systemic immunotoxicity in a clinical irAEs‐mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo‐immunotherapy against cancer with enhanced safety.
The environmental policy of the Norwegian Government Pension Fund‐Global and investors' reaction over time
Authors: Miglietta Federica , Di Martino Giuseppe , Fanelli Viviana 
Published: December 2022

AbstractTaking the greatest socially responsible sovereign wealth fund in the world, namely, the Norwegian Government Pension Fund‐Global (GPF‐G), as a proxy for the world market portfolio, and collecting investment data from 2006 to 2021, our research studies how the attitude of environmentally concerned investors has changed, on different markets, over time, particularly before and after the 2015 Paris Climate Agreement. We investigate, with an event study methodology, what happens to stock prices when companies are excluded from the GPF‐G portfolio for serious environmental violations, unacceptable level of greenhouse gas emissions, or for their involvement in thermal coal processing. In line with previous studies, our results show that Paris Agreement has acted as a catalyst for environmentally conscious behavior by international investors, and this is particularly true in Anglo‐Saxon countries. Especially US, Japanese, Chilean, Indian, and Canadian investors care about the environmental issues that have led to the exclusion from the fund investment portfolio. To the contrary, investors in China, Germany, Australia, and UK seem to have an opposite reaction, as the prices of the excluded stocks increase.
Lenvatinib plus pembrolizumab versus sunitinib for advanced renal cell carcinoma: Japanese patients from the CLEAR study
Authors: Eto Masatoshi , Takagi Toshio , Kimura Go , Fukasawa Satoshi , Tamada Satoshi , Miura Yuji , Oya Mototsugu , Sassa Naoto , Anai Satoshi , Nozawa Masahiro , Sakai Hideki , Perini Rodolfo , Yusa Wataru , Ikezawa Hiroki , Narita Tomoyuki , Tomita Yoshihiko 
Published: December 2022

AbstractBackgroundThe phase 3 CLEAR study demonstrated statistically significantly improved efficacy with lenvatinib plus pembrolizumab versus sunitinib, including progression‐free survival and overall survival, in patients with previously untreated advanced renal cell carcinoma. This subset analysis investigated efficacy and safety in Japanese patients randomized to lenvatinib plus pembrolizumab or sunitinib in the CLEAR study.MethodsProgression‐free survival, overall survival, tumor response, and safety were assessed in Japanese patients with previously untreated advanced renal cell carcinoma randomized to receive lenvatinib plus pembrolizumab (n = 42) or sunitinib (n = 31). Efficacy outcomes were analyzed by independent imaging review per Response Evaluation Criteria in Solid Tumors, version 1.1.ResultsProgression‐free survival was longer with lenvatinib plus pembrolizumab than with sunitinib (median, 22.1 vs. 10.9 months; hazard ratio, 0.39; 95% CI, 0.20–0.74). Median overall survival was not estimable in the lenvatinib plus pembrolizumab arm and 30.6 months in the sunitinib arm (HR, 1.20; 95% CI, 0.39–3.66). Overall survival adjusted for the imbalance of Memorial Sloan‐Kettering Cancer Center prognostic risk group favored lenvatinib plus pembrolizumab (hazard ratio, 0.67; 95% CI, 0.18–2.39). Objective response rate (69.0% vs. 45.2%; odds ratio, 2.71; 95% CI, 1.03–7.10) was higher and median duration of response (20.3 vs. 9.1 months) was longer with lenvatinib plus pembrolizumab versus sunitinib. Grade ≥ 3 treatment‐emergent adverse events occurred in 95.2% versus 87.1% of patients in the lenvatinib plus pembrolizumab versus sunitinib arms.ConclusionsThese findings support lenvatinib plus pembrolizumab as a potential first‐line treatment for Japanese patients with advanced renal cell carcinoma.
N2 Reduction versus H2 Evolution in a Molybdenum‐ or Tungsten‐Based Small‐Molecule Model System of Nitrogenase
Authors: Junge Jannik , Engesser Tobias A. , Tuczek Felix 
Published: December 2022

AbstractMolybdenum dinitrogen complexes have played a major role as catalytic model systems of nitrogenase. In comparison, analogous tungsten complexes have in most cases found to be catalytically inactive. Herein, a tungsten complex was shown to be supported by a pentadentate tetrapodal (pentaPod) phosphine ligand, under conditions of N2 fixation, primarily catalyzes the hydrogen evolution reaction (HER), in contrast to its Mo analogue, which catalytically mediates the nitrogen‐reduction reaction (N2RR). DFT calculations were employed to evaluate possible mechanisms and identify the most likely pathways of N2RR and HER activities exhibited by Mo‐ and W‐pentaPod complexes. Two mechanisms for N2RR by PCET are considered, starting from neutral (M(0) cycle) and cationic (M(I) cycle) dinitrogen complexes (M=Mo, W). The latter was found to be energetically more favorable. For HER three scenarios are treated; that is, through bimolecular reactions of early M‐NxHy intermediates, pure hydride intermediates or mixed M(H)(NxHy) species.
Development and validation of a novel chiral chromatographic method for separation of lenalidomide enantiomers in human plasma
Authors: Vardhan Gyan , Kumar Vikas , Sahu Puran Lal , Prakash Anuj , Nath Uttam Kumar , Handu Shailendra , Dhamija Puneet 
Published: December 2022

AbstractLenalidomide (LND) is an analogue of thalidomide that is second generation immunomodulatory drugs (IMiDs). LND contains asymmetric carbon atom and exist R and S enantiomer. S (−) form of enantiomer are considered to be more potent and biologically active in tumor cell. It is available in racemic form for clinical use. The study aims to develop and validate enantiomer separation of LND in human plasma. The chromatographic enantiomeric separation was achieved on a Daicel‐CSP, Chiralpack IA 4.6 × 250 mm_5 μm. The mobile phase was constituted in combination of methanol:glacial acetic acid at a concentration of 499.50 ml: 50 μl. UV wavelength detection was 220 nm. The RSD% for all validation parameters was found to be within the acceptable limit. The chiral chromatographic (chiral stationary phase–high‐performance liquid chromatography [CSP‐HPLC]) method developed and validated for the quantitative estimation of LND enantiomers S (−) and R (+) in human plasma sample is accurate, precise, robust, stable and selective.
A New Polynitrogen‐Heterocyclic Scaffold 2,4,6,8‐Tetraazanoradamantane Skeleton: Synthesis and Conversion of Its Functionalities
Authors: Cai Rongbin , Li Bing , Hou Tianjiao , Zhou Qi , Liu Yunzhi , Li Huan , Gao Yuan , Zhu Longyi , Luo Jun 
Published: December 2022

Comprehensive Summary2,4,6,8‐Tetraazanoradamantane skeleton is a unique rigid cage‐like organic structure that has not been established. In this article, a facile protocol to build all‐bridge‐position‐functionalized 2,4,6,8‐tetraazanoradamantane skeleton by condensation of glyoxal, primary amines and disubstituted malondialdehydes, which were in situ generated from 2,2‐dipropenyl‐1,3‐dioxolane or 4,4‐dimethoxyhepta‐2,5‐diene via ozonation, is reported for the first time. A variety of primary amines are compatible with this process, and the corresponding 2,4,6,8‐tetraalkyl‐2,4,6,8‐tetraazanoradamantane‐9‐one ethylene or methyl ketals were achieved in 16%—58% yields. N‐Benzyl group could be converted to other functionalities such as acetyl and nitro, which indicates the structural diversity of this scaffold.
Perception of prognosis, quality of life, and distress in patients receiving chimeric antigen receptor T‐cell therapy
Authors: Dhawale Tejaswini M. , Johnson P. Connor , Gaballa Mahmoud R. , Nelson Ashley M. , Lavoie Mitchell W. , Boateng Kofi Y. , Greydanus Claire , Frigault Matthew J. , El‐Jawahri Areej 
Published: December 2022

AbstractBackgroundChimeric antigen receptor (CAR) T‐cell is potentially curative therapy for patients with hematologic malignancies but can cause life‐threatening toxicities. Data on perceptions of prognosis and psychological distress are lacking.MethodsThe authors conducted a cross‐sectional study of patients receiving CAR‐T. Before hospitalization for CAR‐T, patients completed assessments of quality of life (QOL) (Functional Assessment of Cancer Therapy‐General), anxiety and depression symptoms (Hospital Anxiety and Depression Scale) and post‐traumatic stress disorder symptoms (Post‐Traumatic Stress Checklist). Patients also completed the Prognostic Awareness Impact Scale (PAIS), which measures three domains: cognitive understanding of prognosis, emotional coping with prognosis, and adaptive response.ResultsA total of 71.8% (102 of 142) of eligible patients were enrolled. A total of 34% of patients reported that their oncologist said their cancer is curable and 64% reported there was >50% chance of cure. Overall, 26%, 30%, and 21% of patients reported clinically significant depression, anxiety, and posttraumatic stress disorder (PTSD) symptoms, respectively. We found no association between patients' cognitive understanding of prognosis and QOL or mood. Higher emotional coping with prognosis was associated with better QOL (Β = 0.72; SE = 0.10; p = <.001) and lower depression (Β = −0.17; SE = 0.02; p = <.001), anxiety (Β = −0.21; SE = 0.02; p = <.001), and PTSD (Β = −0.43; SE = 0.06; p = <.001) symptoms. Higher adaptive response was associated with better QOL (Β = 0.19; SE = 0.09; p = .028) and lower depression (Β = −0.05; SE = 0.02; p = .023), anxiety (Β = −0.09; SE = 0.02; p = <.001), and PTSD (Β = −0.19; SE = 0.05; p = <.001) symptoms.ConclusionsPatients undergoing CAR‐T report overly optimistic perception of their prognosis and have high rates of psychological distress. Higher emotional coping with prognosis and adaptive response were associated with better QOL and less psychological distress, underscoring the need to develop interventions to promote coping with this treatment.Plain language summary

Patients undergoing chimeric antigen receptor T‐cell therapy experience report overly optimistic perceptions of their prognosis and have high rates of psychological distress.

Notably, higher emotional coping with prognosis and adaptive response were associated with better quality of life and less psychological distress.