bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel selectively amplified DNA sequences in the germline genome of the Japanese hagfish, Eptatretus burgeri
Authors: Nagao Kohei , Otsuzumi Tomoko , Chinone Hitomi , Sasaki Takashi , Yoshimoto Junko , Matsuda Makiko , Kubota Souichirou , Goto Yuji 
Published: December 2022

AbstractIn the Japanese hagfish Eptatretus burgeri, 16 chromosomes (eliminated [E]-chromosomes) have been lost in somatic cells (2n = 36), which is equivalent to approx. 21% of the genomic DNA in germ cells (2n = 52). At least seven of the 12 eliminated repetitive DNA families isolated in eight hagfish species were selectively amplified in the germline genome of this species. One of them, EEEb1 (eliminated element of E. burgeri 1) is exclusively localized on all E-chromosomes. Herein, we identified four novel eliminated repetitive DNA families (named EEEb3–6) through PCR amplification and suppressive subtractive hybridization (SSH) combined with Southern-blot hybridization. EEEb3 was mosaic for 5S rDNA and SINE elements. EEEb4 was GC-rich repeats and has one pair of direct and inverted repeats, whereas EEEb5 and EEEb6 were AT-rich repeats with one pair and two pairs of sub-repeats, respectively. Interestingly, all repeat classes except EEEb3 were transcribed in the testes, although no open reading frames (ORF) were identified. We conducted fluorescence in situ hybridization (FISH) to examine the chromosomal localizations of EEEb3–6 and EEEb2, which was previously isolated from the germline genome of E. burgeri. All sequences were only found on all EEEb1-positive E-chromosomes. Copy number estimation of the repeated elements by slot-blot hybridization revealed that (i) the EEEb1–6 family members occupied 39.9% of the total eliminated DNA, and (ii) a small number of repeats were retained in somatic cells, suggesting that there is incomplete elimination of the repeated elements. These results provide new insights into the mechanisms involved in the chromosome elimination and the evolution of E-chromosomes.
A versatile series‐parallel‐connected bidirectional DC power flow controller for HVDC and MVDC system
Authors: Jin Jiuyang , Zhang Xiaotian , Xiao Zhilin , Ye Yanan , Qiu Xueao , Yang Xu 
Published: December 2022

AbstractThis paper proposes a transformer type dc power flow controller (DCPFC) based on stacks composed of sub‐modules (SMs). The converter can perform dc power flow control independently on point‐to‐point as well as multi‐terminal connection, which can be applied to either high voltage or medium voltage dc grids. In order to explain the operation principle, different operating states of the proposed DCPFC are analysed. With phase‐shift modulation and the closed‐loop current control, the proposed DCPFC can achieve bidirectional power flow regulation. Following the theoretical analysis of the proposed DCPFC, simulation results have verified the feasibility of bidirectional power flow control. A downscaled experimental prototype is also built to demonstrate the operation principle and performance of the proposed DCPFC.
Enhancement of inter‐area oscillation damping by wide‐area controlled hydropower plants
Authors: Fank Daniel , Renner Herwig 
Published: December 2022

AbstractThis paper examines how the combined use of hydro governors and a wide‐area damping controller (WADC) can improve the damping of inter‐area oscillations in power systems. Such oscillations can endanger the stability of power grids, thus damping them is a high priority for transmission system operators (TSO). To ensure that low‐frequency oscillations decay as fast as possible, a modal linear quadratic Gaussian (LQG) is proposed as a wide‐area controller approach. Using the 10‐machine New England Test System, the combined application of the WADC in hydropower plants via generator excitation as well as via the hydro governor is examined for their effectiveness in terms of damping capability. In order to minimize the number of essential PMUs in power systems for the model‐based WADC, the residue‐based input/output signal selection method is applied. To increase the robustness against large disturbance faults, the generator voltage as additional signal is utilized for the WADC. For controller performance and robustness, the verification has been done under various operating points, tie‐line failures as well as different PMU delays. The successful damping of the inter‐area oscillation by means of wide‐area controlled hydropower plants has been also demonstrated through a nonlinear time domain simulation.
Merger identification through photometric bands, colours, and their errors
Authors: Suelves L. E. , Pearson W. J. , Pollo A. 
Published: December 2022

Aims.We present the application of a fully connected neural network (NN) for galaxy merger identification using exclusively photometric information. Our purpose is not only to test the method’s efficiency, but also to understand what merger properties the NN can learn and what their physical interpretation is.Methods.We created a class-balanced training dataset of 5860 galaxies split into mergers and non-mergers. The galaxy observations came from SDSS DR6 and were visually identified in Galaxy Zoo. The 2930 mergers were selected from known SDSS mergers and the respective non-mergers were the closest match in both redshift andrmagnitude. The NN architecture was built by testing a different number of layers with different sizes and variations of the dropout rate. We compared input spaces constructed using: the five SDSS filters:u,g,r,i, andz; combinations of bands, colours, and their errors; six magnitude types; and variations of input normalization.Results.We find that the fibre magnitude errors contribute the most to the training accuracy. Studying the parameters from which they are calculated, we show that the input space built from the sky error background in the five SDSS bands alone leads to 92.64 ± 0.15% training accuracy. We also find that the input normalization, that is to say, how the data are presented to the NN, has a significant effect on the training performance.Conclusions.We conclude that, from all the SDSS photometric information, the sky error background is the most sensitive to merging processes. This finding is supported by an analysis of its five-band feature space by means of data visualization. Moreover, studying the plane of thegandrsky error bands shows that a decision boundary line is enough to achieve an accuracy of 91.59%.
Spezifische OCT-Veränderungen bei einer neuen Mutation im RS1-Gen bei X-chromosomal-rezessiver Retinoschisis
Authors: Waibel Andrea Magdalena , Stoye Johanna Mirjam , Villavicencio-Lorini Pablo , Hoffmann Katrin , Obermaier Carolin , Biskup Saskia , Grünauer-Kloevekorn Claudia 
Published: December 2022

ZusammenfassungDie X-chromosomal rezessive Retinoschisis (XLRS) ist eine seltene vitreoretinale Dystrophie, die durch molekulargenetische Veränderungen im RS1-Gen ausgelöst wird. Sie manifestiert
sich meist in jungem Lebensalter mit einer symmetrisch auftretenden Spaltung unterschiedlicher Schichten der Netzhaut und führt zu einer erheblichen Visusminderung. Die richtige
Diagnosestellung im höheren Lebensalter gelingt wegen unspezifischer OCT-Veränderungen nur selten. Wir berichten über die morphologischen Veränderungen im OCT in unterschiedlichen
Lebensabschnitten bei einer Familie mit XLRS und einer bislang nicht beschriebenen Mutation im RS1-Gen. Unser 78-jähriger Indexpatient stellte sich mit seit der Kindheit bestehenden
Sehstörungen vor. Wir führten bei ihm, seiner klinisch nicht betroffenen Tochter und deren klinisch betroffenem Sohn nach ausführlicher Anamnese, vollständiger klinischer Untersuchung und
Messung mit dem SD-OCT eine genetische Keimbahndiagnostik an DNA aus Blut durch. In der OCT-Untersuchung des Indexpatienten zeigten sich beidseits unspezifische atrophische Veränderungen der
Makula. Bei dem 8-jährigen Enkel zeigte sich funduskopisch die typische Sternform der Makula. Im OCT war eine typische Retinoschisis der Makula sichtbar. Die genetische Untersuchung wies die
bisher nicht beschriebene pathogene Variante c.487T>G; p.Trp163Gly im RS1-Gen bei allen 3 Patienten nach. Auch bei der neu entdeckten RS1-Mutation zeigt sich im Kindesalter
das typische Fundusbild und OCT-Muster, die bei dem 78-jährigen Patienten fehlen. An unserem Fall zeigt sich, dass gerade bei unspezifischen Veränderungen im OCT eine ausführliche
Familienanamnese den wichtigen Hinweis für X-chromosomal-rezessive Vererbung und damit für eine entsprechende molekulargenetische Diagnostik liefern kann und so seltene Netzhauterkrankungen
auch im höheren Alter diagnostiziert werden können.
Psychosoziale Einflussfaktoren auf die Schmerzchronifizierung bei jungen Menschen
Authors: Höfel Lea , Aigner Anna , Rummel-Siebert Martin , Schramm Anja , Haas Johannes-Peter 
Published: December 2022

ZUSAMMENFASSUNGChronische Schmerzen bei Kindern und Jugendlichen werden oft in Zusammenhang mit Angst, Depression und Verhaltensauffälligkeiten gebracht, zugleich begünstigen diese psychischen Auffälligkeiten eine Chronifizierung. Lebensqualität, Angst-Vermeidungs-Tendenzen, elterliches Verhalten und sozioökonomischer Status modulieren ebenfalls Prozesse der Schmerzchronifizierung. Darüber hinaus müssen Schlafverhalten, operative/invasive Eingriffe, spezielle Schmerzarten und -orte und frühkindliche Schmerzerfahrungen als mögliche Prädiktoren für chronische Schmerzen rechtzeitig in Erwägung gezogen werden. Im klinischen Alltag sollten all diese Faktoren in Anamnese, Edukation und Therapieverlauf einbezogen werden. Ein rechtzeitiges Erkennen und Therapieren psychischer und sozialer Belastungen kann die Gefahr der Chronifizierung von Schmerzen reduzieren.
Retinale und choroidale Ultra-Weitwinkel-OCT – Technologie, Einblicke und klinische Bedeutung
Authors: Brockmann Claudia , Brockmann Tobias , Dera Adrianna Urszula , Do Ha-Vy , Rusch Wladislaw , Schaub Friederike , Fuchsluger Thomas Armin , Stachs Oliver 
Published: December 2022

ZusammenfassungDie Ultra-Weitwinkel optische Kohärenztomografie (UWF-OCT) bietet als eine der modernsten Verfahren der retinalen und choroidalen Bildgebung einen deutlichen Zugewinn an Informationen
hinsichtlich peripherer Netzhautläsionen und deren Differenzialdiagnosen. Insbesondere das Vorliegen minimaler Ansammlungen subretinaler Flüssigkeit kann damit detailliert beurteilt und im
Verlauf dokumentiert werden. Auch die choroidale Ausdehnung von Aderhautläsionen kann exakt vermessen werden. Die Limitationen in der Anwendung beschränken sich ähnlich wie bei der
bisherigen OCT nach wie vor auf die Trübung optischer Medien und die Compliance des Patienten. Die Weite der Pupille spielt hier eine eher untergeordnete Rolle, die Qualität der Aufnahmen
ist jedoch in medikamentöser Mydriasis besser. Zusammen mit der UWF-Fundusfotografie ist die UWF-OCT ein hilfreiches Tool in der Beurteilung und Kontrolle peripherer Netzhaut- und
Aderhautläsionen.
Reform oder Brandbeschleuniger?
Authors: Roßius Sabrina 
Published: December 2022

ZusammenfassungMit dem Krankenhauspflegeentlastungsgesetz, kurz KHPflEG, sollen Krankenhäuser verpflichtet werden, ausreichend Pflegekräfte vorzuhalten. Kann dieses Vorhaben gelingen?
Wie sich die Pflege in Deutschland organisiert
Authors: Albrecht Jens 
Published: December 2022

ZusammenfassungPflegekammern sind nicht neu – in den USA und England gibt es die Selbstverwaltung bereits seit über 100 Jahren. Hierzulande gestaltet sich die Etablierung holprig. Hier ein geschichtlicher Überblick und rechtliche Grundlagen zum Thema Verkammerung.
A Novel Homozygous Missense Mutation (Ile583Asn) in a Consanguineous Marriage Family with Hereditary Factor XII Deficiency: A Case Report
Authors: Jiang Shuting , Chen Yuan , Xie Haixiao , Liu Meina , Zheng Xiaoyong , Wang Mingshan 
Published: December 2022

Abstract
Background Hereditary coagulation factor XII (FXII) deficiency is an autosomal recessive disorder. At present, the contribution of severe FXII deficiency to the development of thromboembolism is still undetermined. There are limited reports on the relationship between the FXII defect and thromboembolism.
Case Presentation A 27-year-old woman came to our hospital for the treatment of shoulder trauma and cervical disc herniation caused by a car accident. The shoulder trauma was treated with five stitches. After physical examination, imaging examination, and routine coagulation examination, cervical disc herniation was treated conservatively. Combined with the examination results, the patient was diagnosed with FXII deficiency. Unfortunately, the patient was readmitted 10 days after the trauma with edema in the lower limbs and secondary varicose veins. The D-dimer increased to 6.22 mg/L. Thrombus in the inferior vena cava and right common iliac was shown by lower limb venography. According to the patient's medical history, the F12 gene was analyzed by direct sequencing. The patient was also screened for other thrombotic risk factors. Genetic analysis showed that the patient had a c.1748T > A (p.Ile583Asn) homozygous missense mutation in exon 14 of the F12 gene. No other hereditary thrombophilia risk factors screened were positive in the patient.
Conclusion The p.Ile583Asn missense mutation in exon 14 of the F12 gene might be responsible for the reduction of the FXII level in the patient.
Was hat der Darm mit Übergewicht und Diabetes zu tun?
Authors: Walle Hardy 
Published: December 2022

ZUSAMMENFASSUNGEine gestörte Mikrobiota kann – neben Fehlernährung und Bewegungsmangel – zur Entstehung von Übergewicht und dessen Folgeerkrankungen beitragen. Ballaststoffe wie Betaglucan stabilisieren die Mikrobiota, unterstützen über die erhöhte Sättigung eine Gewichtsabnahme und vermindern hungerauslösende Blutzuckerschwankungen. Für den Menschen unverdauliche Ballaststoffe werden von Darmbakterien zu kurzkettigen Fettsäuren abgebaut, die u. a. die intestinale Darmbarriere verbessern. Ist die Schutzfunktion der Darmschleimhaut gestört, fördert dies die Entwicklung von Adipositas, nichtalkoholischer Fettleber und Typ-2-Diabetes. Die kurzkettigen Fettsäuren beeinflussen zudem Cholesterinspiegel und Blutglukosestoffwechsel positiv.
Comparison of adenoma detection rate and proximal serrated polyp detection rate and their effect on post-colonoscopy colorectal cancer mortality in screening patients
Authors: Zessner-Spitzenberg Jasmin , Waldmann Elisabeth , Jiricka Lena , Rockenbauer Lisa-Maria , Hinterberger Anna , Cook Jeremy , Asaturi Arno , Szymanska Aleksandra , Majcher Barbara , Trauner Michael , Ferlitsch Monika 
Published: December 2022

Background Patients with serrated polyps are at increased risk for post-colonoscopy colorectal cancer (PCCRC); however, evidence for a dedicated serrated polyp detection rate is lacking. The aim of this study was to investigate the association of the proximal serrated polyp detection rate (PSDR) and adenoma detection rate (ADR) with PCCRC death.
Methods This was a retrospective analysis within the Austrian quality assurance program for screening colonoscopy. Spearman’s rank coefficient was calculated for the assessment of association between ADR and PSDR. Whether ADR or PSDR were associated with colorectal cancer mortality was assessed by Cox proportional hazards model.
Results 229/729 screening colonoscopies performed by 308 endoscopists were analyzed. The ADR (hazard ratio [HR] per 1 percentage point increase 0.98, 95 %CI 0.96–0.99) as well as the PSDR (HR per 1 percentage point increase 0.97, 95 %CI 0.94–0.99) were significantly associated with PCCRC death. The correlation coefficient of the ADR and PSDR calculated at every colonoscopy was 0.70 (95 %CI 0.70–0.71), and the corresponding PSDR value for an ADR performance standard of 25 % was 11.1 %. At the end of the study period, 86 endoscopists (27.9 %) reached an ADR of > 25 % and a PSDR of > 11.1 %.
Conclusions The ADR as well as the PSDR were associated with PCCRC death. Striving for a high PSDR in addition to a high ADR might reduce the risk for PCCRC mortality in patients undergoing screening colonoscopy.
Functional and Aesthetic Outcomes of Septal Reconstructions: Results of a Prospective Longitudinal Outcome Study
Authors: van Dam Victor S. , van Zijl Floris V.W.J. , Lohuis Peter J.F.M. , Datema Frank R. 
Published: December 2022

AbstractIn order to correct severe septal deformities, complete septal reconstruction is often required to achieve the desired functional and aesthetic results. Several different techniques have been described. Systematic evaluation of the long-term results is crucial to assess and improve the quality of these surgical techniques. A custom-built dashboard (the rhinoplasty health care monitor [RHM]) was used for prospective and longitudinal outcome evaluation of the septal reconstruction. The RHM includes the Nasal Obstruction Symptom Evaluation (NOSE) scale for nasal obstruction and the Utrecht Questionnaire (UQ) for aesthetic outcome results. In total, 58 patients were included for septal reconstructive surgery. The mean preoperative NOSE scale scores decreased from 67.8 ± 19.1 to 12.2 ± 17.5, 1 year after surgery. Mean preoperative UQ scores went from 12.3 ± 6.4 to 6.2 ± 2.7. The beneficial functional and aesthetic effects of the techniques that we currently use to reconstruct the septum are efficient in terms of function and aesthetics.
Optical Based Techniques for 2D Layered Materials
Authors: Reshmi S. , Sundheep R. , Late Dattatray J. 
Published: December 2022

Two-dimensional materials are the thinnest unsupported crystalline solids that do not exhibit surface dangling bonds. The unique structure of these materials including graphene and its successors leads to novel optical, electrical properties in comparison to their bulk counterparts. The changes in the structural and physical properties thus highly influence the performance of the resulting devices. Particularly, they are characterized by intralayer covalent bonding and interlayer van der Waals bonding with superior interlayer (compared to intralayer) transport of fundamental excitations (charge, heat, spin, and light). These atomic sheets afford the ultimate thickness scalability for semiconductor devices while simultaneously providing an unmatched combination of device physics and mechanics [Akinwande et al., “Two-dimensional flexible nanoelectronics,” Nat. Commun. 5, 5678 (2014)]. Hence, these 2D layers could act as building blocks for future optoelectronic and photonic devices. Even though their unique structure confers various optoelectronic capabilities, the same structure impedes their characterizations as they are transparent and have a nanometre-scale thickness. The future application of these nanosheets will be dictated by our precise understanding of their optoelectronic properties through standardized characterization techniques.
Among all the available characterization techniques, optical investigations are a powerful tool as the interaction between incident light beam and the material can provide us with information about the optoelectronic properties of the materials. The simplicity and the non-destructive nature of these techniques make them an important characterization tool. This chapter deals with the systematic study of various optical methods which are useful in investigating materials of the 2D family. The initial stage in characterizing 2D material is to locate them and count number of layers in the nanosheets. The first section describes the use of optical microscopy as an imaging technique and its usefulness in determining the thickness/layer number in a 2D layer stack. Methods to investigate nonlinear optical properties of 2D materials is discussed in the next section. Photoluminescence emission studies combined with density functional theory can be utilized to characterize the band structure of the 2D materials. Thus, the third section of this chapter describes the use of optical absorption and photoluminescence technique to investigate their electronic properties. Systematic discussion is put forward for the methods to ascertain particle size and surface charge of the materials in the last section.
Scrolling into the Newsroom
Authors: Oesch Jonas , Renner Adina , Roth Manuel 
Published: December 2022

Abstract
In recent years, scrollytelling – a method to animate content as a reader scrolls through an article – has become
an integral part of online visual storytelling. Despite its popularity, few studies have examined the variety of existing
scrollytelling techniques. In addition, scrollytelling is still costly to produce. This study aims to generate a scrollytelling
vocabulary for newsrooms and creative agencies. By analysing 50 examples, we have identified granular characteristics of
scrollytelling elements, or ‘scrollers’, and grouped them into five standard techniques: graphic sequences, animated transitions,
panning and zooming, scrolling through movies, and showing and auto-playing animated content. The study provides information
designers, developers, and visual journalists with a vocabulary to experiment with different scrollytelling techniques and
implement scrollers faster and more easily.
Parallel spinors, pp-waves, and gravitational perturbations
Authors: Araneda Bernardo 
Published: December 2022

Abstract
We prove that any real, vacuum gravitational perturbation of a four-dimensional vacuum pp-wave space-time can be locally expressed, modulo gauge transformations, as the real part of a Hertz/Debye potential, where the scalar potential satisfies the wave equation. We discuss relations with complex perturbations, complex space-times, non-linear structures, and real spaces with split (ultra-hyperbolic/Kleinian) signature. Motivated by generalized notions of parallel spinors, we also discuss generalizations of the result to other space-times.
An adaptive generalized logarithm sparse regularization method and its application in rolling bearing fault diagnosis
Authors: Qin Limu , Yang Gang , Lv Kun , Sun Qi 
Published: December 2022

Abstract
The generalized logarithm sparse regularization method (G-log) for fault diagnosis of rotating devices can effectively reconstruct repetitive transient shocks from noise-disturbed signals, but its reconstruction accuracy frequently becomes inferior due to unsuitable regularization parameters. Moreover, conventional sparse regularization methods perform nothing on the input signals to guarantee that the impulse characteristics remain constant during the entire iteration process, which exacerbates the influence of noise on the reconstruction accuracy. To overcome these challenges, an adaptive generalized logarithm sparse regularization method (AG-log) based on the second-order cyclostationary indicator (ICS2) and the improved maximum correlation Pearson correlation coefficient deconvolution (IMCPCCD) method is proposed in this paper. Firstly, the optimal threshold parameter k for each iteration of AG-log is determined based on the ICS2 criterion to ensure the optimal reconstruction accuracy, while the optimal combination of iteration numbers N and k is established. Secondly, the original signal and the IMCPCCD filtered signal are alternately used as the input signal of AG-log according to the parity of the iterative steps to reduce the interference of noise. Finally, the application on simulated and two engineering case signals demonstrates that AG-log has better reconstruction accuracy compared with conventional nonconvex sparse regularization methods.