bluuebunny/crossref_metadata_2025_split huggingface dataset:
“PrEP should be available all the time and everywhere”: A qualitative assessment of family planning and PrEP integration in Lesotho
Authors: Nonyana Nyane-Matebello , Matete Manthomeng , Lebetkin Elena , Yacobson Irina , Strachan Molly , Ramapepe Makeneiloe Anastasia , Malkin Morrisa , Chakare Tafadzwa 
Published: September 2022

BackgroundLesotho has a high HIV burden, with women disproportionately affected. Increased access points for HIV prevention services, including oral pre-exposure prophylaxis (PrEP), should be considered. Using family planning (FP) settings for PrEP services may contribute to greater uptake of HIV prevention methods.MethodologyThis formative qualitative assessment was conducted in Maseru District, Lesotho and included in-depth interviews with 15 key informants, 10 FP providers in public facilities and community sites, and 15 FP and PrEP clients from facility and community sites. Interviews were audio recorded and in lieu of producing transcripts, teams completed semi-structured data extraction tables after each interview. Findings were compiled and synthesized by participant group into matrices and themes identified through deductive and inductive analysis.ResultsPolicy makers were generally supportive of integration but felt hampered by lack of integration policies and separation of HIV and FP departments at Ministry of Health. Funders stressed the need for coordination among partners to avoid duplication of efforts. Partners felt clients would be interested in PrEP/FP integration and that PrEP demand creation and education were crucial needs. Most providers supported integration, stressing the potential benefit to clients. Barriers discussed included heavy workloads, staff shortages, training needs, separate registers for FP and PrEP, and commodity stock-outs. Providers discussed strengthening integrated services through training, increasing staffing, having job aids and guidelines, merging the FP and PrEP registers, and marketing services together to create demand for both. Clients were overwhelmingly willing to have longer visits to receive comprehensive services and were supportive of receiving PrEP services from FP providers. Clients not using PrEP expressed willingness and interest to use. Clients' suggestions for successful integration included consulting with youth, conducting community outreaches, and improving provider availability.ConclusionsExisting FP platforms are established and well-utilized; thus providing opportunities for integrating PrEP. This assessment found support across all groups of respondents for providing PrEP within FP settings and identified a number of facilitators and barriers to integration. As PrEP rollout is relatively nascent in many countries, deepening the evidence base early will enable the utilization of findings to build stronger integrated programs with wider coverage.
LabSAR, a one-GCP coregistration tool for SAR–InSAR local analysis in high-mountain regions
Authors: Weissgerber Flora , Charrier Laurane , Thomas Cyril , Nicolas Jean-Marie , Trouvé Emmanuel 
Published: September 2022

The coregistration of single-look complex (SLC) SAR images for InSAR or offset tracking applications is often performed by using an accurate DEM and precise orbital information. However, in cold regions, such DEMs are rare over high-latitude areas or not up-to-date over fast melting glaciers for instance. To overcome this difficulty, we propose in this article a coregistration method preserving InSAR phase information that only requires a 3D point of reference instead of a full DEM. Developed in a Python toolbox called LabSAR, the proposed method only uses orbital information to coregister the images on the sphere centered on the Earth center passing by the ground control point (GCP). Thanks to the use of the orbital information, the so-called orbital fringes are compensated without having to estimate them. This coregistration method is compared to other approaches in two different types of applications, InSAR and offset tracking, on a PAZ Dual-Pol Temporal Stack covering the Mont Blanc massif (western European Alps). First, InSAR measurements from LabSAR are compared with the results of the Sentinel-1 ESA toolbox (SNAP). The LabSAR interferograms exhibit clearer topographical fringes, with fewer parameters to set. Second, offset tracking based on LabSAR coregistated images is used to measure the displacement of the Bossons glacier. The results are compared with those obtained by a conventional approach developed in the EFIDIR tools. By evaluating the uncertainties of both approaches using displacements over stable areas and the temporal closure error, similar uncertainty values are found. However, velocity values differ between the two approaches, especially in areas where the altitudes are different from the altitude of the reference point. The difference can reach up to 0.06 m/day, which is in the range of the glacier velocity measurement uncertainty given in the literature. The impact of the altitude of the reference point is limited: this single GCP can be chosen at the median altitude of the study area. The error margin on the knowledge of this altitude is 1,000 m, which is sufficient for the altitude to be considered as known for a wide range of study area in the world.
Spatial extent of the energetic electron precipitation region during substorms
Authors: Bland Emma , Bozóki Tamás , Partamies Noora 
Published: September 2022

The spatial coverage of the energetic electron precipitation (EEP) region during three substorms has been determined using a combination of ground-based instruments in North America. The primary datasets used to determine the presence or absence of EEP are riometer measurements of cosmic noise absorption (CNA); attenuation of the 10–11 MHz atmospheric noise in the D-region ionosphere determined using the Super Dual Auroral Radar Network (SuperDARN); amplitude variations in subionospheric very low frequency (VLF) propagation observed using the Antarctic-Arctic Radiation-belt (Dynamic) Deposition VLF Atmospheric Research Konsortium (AARDDVARK) VLF receivers, and total electron content measurements derived from global navigation satellite systems. Our results show that substorm EEP during moderate geomagnetic conditions can extend considerably equatorward or poleward of the average latitude limits reported in a previous statistical study of substorm EEP and an EEP model. This evidence is provided by the SuperDARN radars and the radar signature is not always accompanied by cosmic noise absorption measured by the riometers. Further work is required to determine which EEP energies and fluxes the SuperDARN radars are sensitive to, but we can conclude that EEP with sufficient flux to attenuate 10–11 MHz radiowaves by ∼5 dB reaches latitudes well equatorward of the statistical EEP latitude limits previously modelled for >30 keV electrons.
Top 100 most cited articles on anterior cervical discectomy and fusion
Authors: Ding Zhiyu , Ren Yijun , Cao Hongqing , Li Jinsong 
Published: September 2022

Study DesignBibliometric analysis.ObjectiveAnterior cervical discectomy and fusion (ACDF) is a typical surgical method in spine surgery and has progressed significantly in the last several decades. The purpose of this study is to determine how the 100 most-cited original articles on ACDF have been the most influential in this field by identifying and analyzing them.MethodsThe articles on ACDF were identified by searching the Thomson ISI Web of Science database on 30 May 2022. The 100 most-cited articles were selected according to specific criteria. The data extracted from the articles included title, publication date, total citations, journal name, first author, institutions, and keywords.ResultsThe total number of citations was 13,181, with a mean number of 131.81 ± 100.18. The publication dates ranged from 1994 to 2018. Most of these articles originated in the United States (68%) and were published in the 2000s (32%) and 2010s (48%). Spine published most of the articles (30%), followed by the Journal of Neurosurgery-Spine (16%), Spine Journal (14%), and European Spine Journal (13%). The most prolific author was Dr. Todd J Albert (n = 7), with 1,312 citations. The Texas Back Institute was the most productive institution (n = 10). The keywords ACDF, cervical spine, cervical spine, and fusion showed the highest degree of centrality.ConclusionOne hundred top-cited articles on ACDF were identified and analyzed in this study. We demonstrate that ACDF is a growing and popular area of research, with the focus of research varying through timeline trends. This will provide a comprehensive and detailed basis for spine surgeons to make clinical decisions and assimilate the research focus of cervical spine surgery.
Outpatient total knee and hip arthroplasty present comparable and even better clinical outcomes than inpatient operation
Authors: Gong Song , Yi Yihu , Wang Ruoyu , Han Lizhi , Gong Tianlun , Wang Yuxiang , Shao Wenkai , Feng Yong , Xu Weihua 
Published: September 2022

BackgroundThe purpose of this study was to compare total complications, complications stratified by type, readmissions, and reoperations at 30 and 90 days after outpatient and standard inpatient total knee and total hip arthroplasty (TKA, THA).MethodsA literature search was conducted from the PubMed, Cochrane Library, and Embase databases for articles published before 20 August 2021. The types of studies included prospective randomized controlled trials, prospective cohort studies, retrospective comparative studies, retrospective reviews of THA and TKA registration databases, and observational case-control studies. Comparisons of interest included total complications, complications stratified by type, readmissions, and reoperations at 30 and 90 days. The statistical analysis was performed using Review Manager 5.3.ResultsTwenty studies with 582,790 cases compared relevant postoperative indicators of outpatient and inpatient total joint arthroplasty (TJA) (TKA and THA). There was a significant difference in the total complications at 30 days between outpatient and inpatient THA (p = 0.001), readmissions following TJA (p = 0.03), readmissions following THA (p = 0.001), stroke/cerebrovascular incidents following TJA (p = 0.01), cardiac arrest following TJA (p = 0.007), and blood transfusions following TJA (p = 0.003). The outcomes showed an obvious difference in 90-day total complications between outpatient and inpatient TJA (p = 0.01), readmissions following THA (p = 0.002), and surgical-related pain following TJA (p &lt; 0.001). We did not find significant differences in the remaining parameters.ConclusionOutpatient procedures showed comparable and even better outcomes in total complications, complications stratified by type, readmissions, and reoperations at 30 and 90 days compared with inpatient TJA for selected patients.
Neurological outcomes of extended thymectomy for thymomatous myasthenia gravis: Subxiphoid vs. trans-sternal approaches
Authors: Zhu Haoshuai , Liu Zhihao , Yao Xiaojing , Zou Jianyong , Zeng Bo , Zhang Xin , Chen Zhenguang , Su Chunhua 
Published: September 2022

BackgroundThe subxiphoid approach has been widely used recently. However, there is little data focusing on neurological outcomes in patients with thymomatous myasthenia gravis (MG) who underwent subxiphoid thoracoscopic thymectomy. The purpose of this study was to compare the neurological outcomes of patients with thymomatous MG who underwent extended thymectomy with a subxiphoid or transthoracic approach 1 year postoperatively.MethodsThe records of patients with Masaoka stage I and II thymomas who underwent extended thymectomy from January 2019 to December 2020 with tumor size less than 5 cm and thymomatous MG were retrospectively reviewed and evaluated. Neurological outcomes were measured by a quantitative myasthenia gravis score (QMGS), with a 2.3-point reduction in QMGS associated with improvement in clinical MG status. The clinical efficacy and variables affecting the outcomes were assessed using the Kaplan–Meier method and Cox proportional hazard regression analysis.ResultsA total of 89 patients were included in the analysis, of which 44 had a subxiphoid approach and 45 had a trans-sternal approach. Mean QMGS decreased from 12 at initial diagnosis to 8.7 preoperatively and 5.6 at 12 months postoperatively in the subxiphoid group and from 12.1 to 8.9 to 6.0 in the transthoracic group. Thirteen patients (28.9%) who underwent the trans-sternal approach and 10 (22.7%) who underwent the subxiphoid approach did not have an improved clinical status compared with their preoperative status. The median time to clinical improvement was 3 months (95% CI, 2.15–3.85) for the subxiphoid approach and 6 months (95% CI, 5.54–6.46) for the trans-sternal approach. Univariate results showed that the subxiphoid approach was associated with a faster improvement in clinical status (HR = 1.701, 95% CI, 1.044–2.773, P &lt; 0.05), and age ≦48 was associated with a faster improvement in clinical status (HR = 1.709, 95% CI, 1.044–2.799, P &lt; 0.05). The multivariate model including age ≦48 (HR = 1.837, 95% CI, 1.093–3.086, P = 0.022) and the subxiphoid approach (HR = 1.892, 95% CI, 1.127–3.177, P = 0.016) was significantly associated with a faster improvement in clinical status.ConclusionsIn patients with Masaoka stage I and II thymoma who underwent thymectomy, with tumor size less than 5 cm and thymomatous MG, age ≦48 years and the subxiphoid approach were associated with a rapid improvement in clinical status.
Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches
Authors: Grassilli Silvia , Bertagnolo Valeria , Brugnoli Federica 
Published: September 2022

The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play crucial and partially overlapped functions in solid tumors, in which the different isoforms are variously de-regulated and mainly correlated with tumor suppression. miR-29b is the most expressed family member in cancer, in which it is involved in regulating gene expression at both transcriptional and post-transcriptional levels. This review focuses on the role of miR-29b in breast cancer, in which it plays a controversial role as tumor suppressor or onco-miRNA. Here we have highlighted the dual effect of miR-29b on breast tumor features, which depend on the prevailing function of this miRNA, on the mature miR-29b evaluated, and on the breast tumor characteristics. Remarkably, the analyzed miR-29b form emerged as a crucial element in the results obtained by various research groups, as the most abundant miR-29b-3p and the less expressed miR-29b1-5p seem to play distinct roles in breast tumors with different phenotypes. Of particular interest are the data showing that miR-29b1-5p counteracts cell proliferation and migration and reduces stemness in breast tumor cells with a triple negative phenotype. Even if further studies are required to define exactly the role of each miR-29b, our review highlights its possible implication in phenotype-specific management of breast tumors.
Diagnóstico de la ansiedad personal del adolescente en las actividades educativas
Authors: Aminova D.K. , Skoblikova T.V. , Latipov Z.A. , Listik E.M. , Kurganova E.A. 
Published: September 2022

The paper provides a theoretical and analytical review of modern methods of diagnosing anxiety states and personal anxiety, which have been used by Russian scientists in recent years. The paper presents the arguments of scientists about the nature and psychological and pedagogical characteristics of personal anxiety as a property of personality, mental state and character traits. The paper describes the scientific apparatus and methodological tools of diagnostic procedures. The methods used in the study (observation, survey, analysis of the products of educational activity, Spielberg-Khanin’s method of personal and situational anxiety, the J. Taylor’s method of measuring the level of anxiety, the method “Multidimensional assessment of child anxiety” (MACA), statistical methods of data processing are highlighted and the empirical results are discussed. The results indicat that it is necessary to separate the scientific concepts of anxiety and uneasiness as non-fundamental and having a different psychological and physiological basis.
Pokok-pokok Ajaran Aswaja Menurut KH. Ma'ruf Irsyad Kudus
Authors: Rohman Fathur 
Published: September 2022

KH. Ma'ruf Irsyad is one of the Kiai from Kudus city who is very consistent and eager in fighting for the teachings of Ahl al-Sunnah wa al-Jama'ah. Besides being active in the PCNU management of Kudus Regency, he also actively campaigned aswaja teachings through madrasa and majlis ta'lim. According to him, Aswaja is the best way to carry out Islamic teachings because Aswaja was pioneered by the Salaf scholars whose scientific sanad continued to the Prophet and his companions. Kiai Ma'ruf refused propaganda “back to the Qur'an and Hadith” because digging Islamic teachings from its immediate source is not an easy matter that can be done by just anyone. Without the tools of science and high integrity, exploring Islamic teachings directly from the source will actually lead to being lost and misleading. Therefore, the safest way to practice Islam is by following the salaf scholars. This article discusses the important points of the teachings of Ahl al-Sunnah wa al-Jama'ah according to KH. Ma'ruf Irsyad Kudus. There are nine points presented by KH. Ma'ruf Irsyad about the Aswaja teachings, namely: using mizan al-syar'i, consistent with the truth, maintaining unity, following the salaf scholars, prioritizing the Shari'a rather than reason, the Shari'ah as a measure of good and bad, taqwa in all conditions, benefiting humans, doing sincerely.
Etika Sabar Dalam Berdakwah Perspektif Syaikh Ali Mahfudz
Authors: Maun Maun 
Published: September 2022

AbstrakPenyeru agama dalam menyampaikan pesannya sudah menjadi ketentuan Allah bahwa ia akan dicoba dengan dihadapkan beberapa ujian seperti hujatan, pengolok-olok bahkan kekerasan yang tidak lain sesuai dengan kemampuan hambanya. Semua itu merupakan ujian dan siapa yang dapat melaluinya dengan kesabaran (lapang dada) maka ia akan mendapatkan imbalan oleh karena itu sabar merupakan sifat yang harus dimiliki oleh siapapun, sebab dengan kesabaran seorang hamba mampu menguatkan diri dalam menghadapi cobaan apapun dalam ajarann islam sifat sabar merupakan akhlak yang mulia, seorang da’i harus memiliki sifat yang terpuji itu untuk dijadikan sebuah benteng dalam perjalann dakwahnya, dengan demikian penelitian ini untuk mengetahui Pemikiran Syekh Ali Mahfudz dalam kitab Hidayat al Mursyidin tentang sifat Sabar bagi seorang da’i. Jenis penelitian yang dilakukan adalah studi pustaka (library research) dengan metode analisis deskriptif menurut Syekh Ali Mahfudz bahwa salah satu kunci kesuksesan dalam berdakwa adalah seorang da’i harus memiliki sifat sabar sebagaiman a yang telah dimiliki Rasul ketika berdakwahKata kunciSabar, da’i, pemikiran syekh Ali Mahfudz AbstractThe caller of religion in conveying his message has become God's provision that he will be tried by being faced with several tests such as blasphemy, ridicule and even violence that are none other than the ability of his servant. All of this is a test and whoever can go through it with patience, he will get a reward, therefore patience is a trait that must be possessed by anyone, because with patience a servant is able to strengthen himself in the face of any trial in Islamic teachings. noble character, a preacher must have a commendable nature to be used as a fortress in his da'wah journey, thus this research is to find out the thoughts of Sheikh Ali Mahfudz in the book Hidayat al Mursyidin about the nature of patience for a preacher. The type of research carried out is library research with descriptive analysis methods according to Sheikh AliMahfudz that one of the keys to success in preaching is that a preacher must have a patient nature as the Apostle had when preaching.KeywordsPatience, da'i, the thoughts of Sheikh Ali Mahfudz
Penanaman Nilai-Nilai Pendidikan Ahlussunnah Wal Jamaah An-Nahdliyyah di SMP Islam Pecangaan Jepara
Authors: Fikar Sirojul , Saefudin Ahmad 
Published: September 2022

AbstrakPenelitian ini bertujuan untuk menggambarkan peran guru PAI dalam menanamkan nilai-nilai pendidikan ahlussunnah wal jamaah (Aswaja) di SMP Islam Pecangaan. Selain itu, juga untuk mengidentifikasi faktor pendukung dan penghambatnya. Penelitian kualitatif berjenis field research ini menggunakan teknik observasi, wawancara, dan dokumentasi dalam pengumpulan data. Hasil penelitian menunjukkan bahwa nilai ahlussunah wal jamaah An-Nahdliyah yang ditanamkan oleh guru PAI kepada siswa meliputi tawassuth, tawazzun, tasamuh dan i'tidal. Sebagai konservator, guru PAI berperan memberikan arahan berupa materi terkait dengan moderasi Islam yang bisa dilaukan dalam kehidupan sehari-hari seperti toleransi, berbuat baik kepada sesama, dan menghormati pendapat orang lain. Guru PAI juga selaku inovator yang memiliki ide-ide baru dalam menanamkan nilai ahlussunah wal jamaah An-Nahdliyah. Selaku transmitor, guru PAI memanfaatkan metode ceramah dan dakwah untuk menanamkan nilai ahlussunah wal jamaah An-Nahdliyah. Aspek latar belakang pendidikan guru PAI menjadi faktor pendukung penanaman nilai Aswaja An-Nahdliyyah, di samping juga faktor kedewasan berpikir siswa. Fasilitas dan lingkungan sekolah juga menambah daya dukung penanaman nilai-nilai tersebut. Pada sisi yang lain, adanya guru yang linearitas kesarjanaannya kurang sesuai menjadi faktor penghambat penanaman nilai Aswaja An-Nahdliyyah.
ЗАЦІКАВЛЕНІСТЬ ІНВЕСТОРІВ – ЗАПОРУКА УСПІХУ ІННОВАЦІЙНОЇ ДІЯЛЬНОСТІ КОМПАНІЇ
Authors: Іоргачова Марія , Ковальова Олена 
Published: September 2022

В статті зазначено, що спроможність компаній втілювати нові ідеї та рухатися в напрямку сучасних запитів є основою здійснення нею інноваційної діяльності. В залежності від того на якому рівні здійснює компанія інноваційну діяльність, залежить рівень її конкурентоспроможності та спроможність адаптуватися до змін в сучасному світі. Саме здійснення інноваційної діяльності дозволяє компанії досягати запланованих фінансових показників в процесі своєї фінансово-господарської діяльності. Дані щодо інноваційної діяльності промислових підприємств вказують на її низький рівень та наявність потенціалу для подальшого розвитку. Існуючі джерела фінансування інноваційної діяльності теж свідчать про їх невдалу структуру та наявність потенціалу до їх розширення. Перш за все, це стосується такого джерела як ресурси інвесторів, яке має дуже низку частку та не використовується у нашій країні в повному обсязі. Автори відмічають наявність прірви між можливими потенційними фінансовими ресурсами інвесторів (як внутрішніх так й зовнішніх) та їх мотивації щодо здійснення ними інвестиційної діяльності у зв’язку з відсутністю певних вигідних та привабливих фінансових інструментів. Автори висловлюють думку про можливий напрямок вирішення цієї проблеми завдяки появі відповідних корпоративних фінансових інструментів спрямованих саме на реалізацію компаніями своєї інноваційної діяльності, оскільки участь та зацікавленість потенційних інвесторів може стати необхідним джерелом та запорукою успіху інноваційної діяльності вітчизняних компаній.