bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KINERJA PEGAWAI DAN FASILITAS TERMINAL KEBERANGKATAN TERHADAP KEPUASAN PENUMPANG DI BANDAR UDARA DOUW ATURURE NABIRE
Authors: Rahmasari Aninda , Yudianto Kifni 
Published: July 2022

Bandar Udara Douw Aturure adalah bandar udara yang merupakan akses keluar masuknya masyarakat Nabire baik keluar daerah atau ke daerah pedalaman Meepago (Dogiyai, Deiyai, Nabire, Intan Jaya, Paniai dan Mimika). Bandar Udara Nabire Merupakan aset atau infrastruktur penting bagi masyarakat Nabire. Dan merupakan salah satu pintu keluar masuknya kegiatan perekonomian maupun perpindahan, dimana jasa pelayan bandar udara memberikan fasilitas dan kinerja terbaiknya. Maka fasilitas dan pelayanan bandar udara ini perlu adanya pendukung untuk kenyamanan dan keamanan penumpang dijelaskan dalam Peraturan Menteri Perhubungan Republik Indonesia Nomor PM 178 Tahun 2015 Pasal 1 ayat 8-9. Tetapi dari hasil penelitian masih terdapat keluhan dari pengaruh kinerja dan fasilitas terhadap kepuasan penumpang, sebab itu makan penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh kinerja dan fasilitas terhadap kepuasan penumpang di Bandar Udara Douw Aturure Nabire, dengan jumlah responden atau sampel sebanyak 118 orang minimal menggunakan jasa Bandar Udara Nabire dua kali. Alat uji hipotesis yang di gunakan adalah regresi Liniear berganda. Dari hasil pengujian diketahui bahwa ketiga hipotesis yang di ajukan dua di terima dan satu di tolak, dalam hal ini dapat di artikan bahwa kinerja pegawai bandara sudah baik namun untuk fasilitas berpengaruh terhadap kepuasan penumpang. Dari hasil penelitian ini juga dapat diketahui kinerja dan pelayanan berpengaruh terhadap kepuasan penumpang sebesar 71,3%, sedangkan sisanya sebesar 28,7% dijelaskan oleh variabel lain
PENGARUH IKLAN DI MEDIA SOSIAL DAN WORD OF MOUTH TERHADAP KEPUTUSAN PEMBELIAN TIKET MASKAPAI CITILINK DI BANDAR UDARA AHMAD YANI SEMARANG
Authors: Eva Nurhaliza Putri 
Published: July 2022

Dengan semakin berkembangnya penggunaan sosial media, maka banyak perusahaan yang memasang iklan di media sosial untuk membangun keinginan membeli konsumen. Tujuan penelitian ini adalah untuk menguji pengaruh iklan di media sosial dan word of mouth terhadap keputusan pembelian tiket maskapai Citilink di Bandar Udara Ahmad Yani Semarang. Penelitian ini menggunakan pendekatan deskriptif kuantitatif. Metode yang digunakan dalam penelitian ini adalah metode survei, dengan instrumen angket dan subjek penelitian yang di gunakan adalah penumpang Citilink di Bandar Udara Ahmad Yani yang berjumlah 100 orang. Analisis data dan pengujian hipotesis dikerjakan dengan menggunakan analisis regresi linier berganda melalui SPSS versi 22. Dari hasil penelitian diperoleh bahwa secara parsial iklan di media sosial tidak memiliki pengaruh terhadap keputusan dengan nilai thitung sebesar -.525. Sedangkan Word Of Mouth memiliki pengaruh yang positif dan signifikan terhadap keputusan pembelian dengan nilai thitung sebesar 4.478. Secara simultan kedua variabel memiliki pengaruh yang signifikan terhadap keputusan pembelian dengan nilai fhitung sebesar 10.030.
Nghiên cứu mối liên quan giữa biến đối đổi cấu trúc thùy trán và một số đặc điểm lâm sàng ở bệnh nhân nghiện rượu mạn tính
Authors: Đinh Việt Hùng , Nguyễn Đình Khanh , Đỗ Xuân Tĩnh , Bùi Quang Huy , Huỳnh Ngọc Lăng , Nguyễn Văn Linh 
Published: July 2022

Tóm tắt
Đặt vấn đề: Nghiên cứu từ các kích thước nhân trắc bàn tay, kích thước chi trên, chiều cao đứng và cân nặng trên người đã cho ra nhiều ứng dụng quan trọng trong các chuyên ngành như Phục hồi chức năng, Ngoại khoa, Chấn thương chỉnh hình, Y học lao động… Mục tiêu: Xác định một số kích thước bàn tay, kích thước chi trên, chiều cao đứng và cân nặng của sinh viên Trường Đại học Y Dược Thái Bình. Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang trên 620 sinh viên Trường Đại học Y Dược Thái Bình từ 8/2021 - 03/2022. Kết quả: Chỉ số BMI trung bình 18,91 ± 2,16 ở nữ giới và 20,66 ± 3,13 ở nam giới. Trong nhóm kích thước bàn tay, chiều dài bàn tay nam giới (17,82 ± 0,83 cm) lớn khác biệt so với nữ giới (16,42 ± 0,74 cm), độ dài ngón giữa lớn nhất từ 73 - 78 mm, ngón áp út luôn dài hơn ngón trỏ, khoảng 72 mm so với 58 mm ở nam giới và 67 mm so với 53 mm ở nữ giới. Ngón cái có độ rộng nhất, sau đó là ngón giữa, ngón trỏ, ngón áp út và ngón út (từ 15,5 - 12,0 mm). Độ dày các ngón cũng tương tự; tuy nhiên, ngón áp út dày hơn ngón trỏ (8,92 ± 0,78 mm so với 8,29 ± 0,78 mm ở nam giới). Chiều dài chi trên ở nam giới lớn hơn so với dài chi trên ở nữ giới (76,12 cm ở nam giới và 70,17 cm ở nữ giới) với p < 0,05; tuy nhiên, chiều dài xương cánh tay ở hai giới có sự chênh lệch ít nhất (29,19 cm ở nam giới so với 27,4 cm ở nữ giới). Kết luận: Các kích thước nhân trắc bàn tay, chiều dài chi trên, chiều cao đứng và cân nặng ở nam giới đều lớn hơn nữ giới, sự khác biệt có ý nghĩa thống kê với p < 0,05. Chiều dài và độ dày ngón áp út luôn lớn hơn ngóntrỏ, nhưng độ rộng thì ngược lại với p < 0,05. * Từ khóa: Nhân trắc bàn tay; Chi trên; Chiều cao đứng; Cân nặng.
AGE, AUTOIMMUNITY, AND INFLAMMATION: THE CURIOUS CASE OF IMMUNOSENESCENCE AND INFLAMM-AGING
Authors: Sundaram T. G. , Ahmed Sakir 
Published: July 2022

An ever-aging population has caused an increase in the prevalence of diseases which occur in the elderly like diabetes and cancer; and autoimmune disease like rheumatoid arthritis (RA). On the other hand, ageing also causes an increased susceptibility to infections, reactivation of latent infections and a poorer vaccine response. Together, this ageing-related decline in immunity is called immunosenescence and the associated ageing-related inflammation is called inflamm-aging.
In this brief review, we describe the changes seen with ageing in innate and adaptive immunity and how these lead to the various peculiarities associated with ageing in the immune system. TEMRA cells, Senescence associated secretory phenotype (SASP) and exhausted T cells are the main changes that occur in ageing T cells. Age-associated B cells (ABCs) contribute to changes associated with autoimmunity in elderly. In the innate arm, the macrophages-led inflamm-aging cause an overall net pro-inflammatory state. However, the macrophages have reduced phagocytosis leading to accumulation of necrotic and apoptotic debris.
We also attempt to explain how immunosenescence and inflamm-aging cause defective vaccine responses and an increased predisposition to autoimmune diseases. As the average life expectancy of the world continues to increase, this is not just a curiosity to study at whim, but an indispensable part of medicine in the near-future.
Amorphous Precursor‐Mediated Calcium Phosphate Coatings with Tunable Microstructures for Customized Bone Implants
Authors: Wang Li‐Na , Meng Yu‐Feng , Feng Yanhuizhi , Wang Hai‐Cheng , Mao Li‐Bo , Yu Shu‐Hong , Wang Zuo‐Lin 
Published: July 2022

AbstractCalcium phosphate (CaP) is frequently used as coating for bone implants to promote osseointegration. However, commercial CaP coatings via plasma spraying display similar microstructures, and thus fail to provide specific implants according to different surgical conditions or skeletal bone sites. Herein, inspired by the formation of natural biominerals with various morphologies mediated by amorphous precursors, CaP coatings with tunable microstructures mediated by an amorphous metastable phase are fabricated. The microstructures of the coatings are precisely controlled by both polyaspartic acid and Mg2+. The cell biological behaviors, including alkaline phosphatase activity, mineralization, and osteogenesis‐related genes expression, on the CaP coatings with different microstructures, exhibit significant differences. Furthermore, in vivo experiments demonstrate the osseointegration in different types of rats and bones indeed favors different CaP coatings. This biomimetic strategy can be used to fabricate customized bone implants that can meet the specific requirements of various surgery conditions.
Intelligent agricultural tourism recommendation based on smart network
Authors: Zhang Shaoxia 
Published: July 2022

AbstractTo provide agricultural tourism tourists with services that meet their various needs, it is necessary to fully clarify the information needs of tourists and achieve efficient management. The prerequisite for achieving efficient management requires fully grasping the influencing factors of tourists' various information behaviors. In order to improve the effect of agricultural tourism recommendation, this paper improves the agricultural intelligent tourism recommendation algorithm, and constructs the data processing module in combination with the intelligent network. Moreover, this paper constructs the system function structure according to actual needs, and analyzes the effect of the system through experimental research. From the experimental research, it can be seen that the agricultural intelligent tourism recommendation system based on the smart network constructed in this paper has a good recommendation effect, the response is very good among customers, and the customer satisfaction is high.
What do we mean when we have a “sinus infection?”
Authors: Riley Charles A. , Navarro Alvaro I. , Trinh Lily , Abuzeid Waleed M. , Humphreys Ian M. , Akbar Nadeem A. , Shah Sharan , Lee Jivianne T. , Wu Tara , Schneider John S. , Tolisano Anthony M. , McCoul Edward D. 
Published: July 2022

AbstractIntroductionSinus infections are a common reason patients seek medical care. However, the intended meaning of the term sinus infection among patients and otolaryngologists is incompletely understood.MethodsIn this multi‐institutional cross‐sectional study, a semantics‐based questionnaire was provided to consecutive patients presenting to otolaryngology clinics at six academic centers from June 2020 until May 2021. The primary outcome was respondent definitions for sinus infection from a list of 28 proposed terms covering six general categories. Secondary outcome measures included differences between geographic regions.ResultsResponses were obtained from 560 patients (54% female, mean age 48.9 years) and 29 otolaryngologists (42% female, mean age 37.4 years). Patients and otolaryngologists selected a median of 10 and 11 terms, respectively, to define a sinus infection. Among patients the most frequently selected symptom categories were mucus (500, 89.3%), pressure/pain (480, 85.7%), and airflow (468, 83.6%). Compared to patients, clinicians selected with greater frequency the symptom categories of pressure/pain (14.3% difference; 95% CI, 7.6% to 22.5%), mucus (10.7% difference; 95% CI, 4.7% to 18.3%) and airflow (13.0% difference; 95% CI, 4.8% to 21.7%). Multiple categories were selected by 96% of patients and 100% of providers.ConclusionThe definition of sinus infection appears variable for both patients and otolaryngologists, though patients appear to apply a broader range of symptoms to the term sinus infection. There were no pronounced geographic differences in the description of a sinus infection in this US sample population. Patients commonly described sinus infection in the context of pain‐related symptoms. Appreciation of these semantic differences may enable more effective patient‐clinician communication.
Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway
Authors: Zhu Lin , Liu Sha , Liao Yi‐Fan , Sheng Yan‐Mei , He Ji‐Chun , Cai Zheng‐Xue , Man Qiong , Wu Yi‐Ying 
Published: July 2022

AbstractHigh intake of phytoestrogen has been reported to be associated with the prevention of colorectal cancer (CRC). Calycosin belongs to the phytoestrogen that has been shown to suppress CRC cells in our previous study. However, its anticancer activity and molecular mechanisms have not been elucidated. In this study, we analyzed the effect of calycosin on the viability and apoptosis of human CRC HCT116 and SW480 cells via MTT assay, flow cytometry assay, and caspase‐3/7 activity assay. The protein expressions of estrogen receptor β (ERβ), PTEN, and PI3K/Akt signal pathways were determined by Western blot analysis. And then, the alterations of biological behavior in CRC cells transfected with ERβ siRNA were analyzed. Mouse xenograft models were further performed to detect the antitumor effect in vivo. The results show that calycosin reduces CRC cell viability, induces cell apoptosis, and suppresses xenograft tumor growth. The protein expressions of ERβ and PTEN are significantly upregulated following calycosin treatment, whereas p‐AKT/AKT ratio and Bcl‐2 level are downregulated. Suppressing ERβ with siRNA partially attenuates the reduction in viability and apoptosis induced by calycosin. Our results indicate that calycosin shows inhibitory effects on CRC cells, which might be obtained by targeting ERβ, upregulating PTEN, and inhibiting the PI3K/Akt signal pathway.
PIK3CB promotes oesophageal cancer proliferation through the PI3K/AKT/mTOR signalling axis
Authors: Xu Wei , Wang Zhiqiang , Zhang Zhi , Xu Jian , Jiang Yuequan 
Published: July 2022

AbstractPIK3CB is abnormally expressed in various carcinomas and affects the proliferation, invasion and drug resistance of cancer cells. However, its role in oesophageal squamous cell carcinoma (ESCC) is still unclear. In this study, PIK3CB was found to be highly expressed in ESCC tissues and cells and positively correlated with the poor prognosis of ESCC. Silencing PIK3CB inhibited the proliferation of ESCC cells, arrested the cell cycle, and promoted apoptosis. Mechanistic studies showed that the tumour‐promoting effect of PIK3CB was achieved through PI3K/AKT/mTOR signalling pathway activation. Moreover, the high PIK3CB expression level in ESCC may be closely associated with the hypomethylation status of the gene promoter. In conclusion, PIK3CB promotes ESCC by activating the PI3K/AKT/mTOR signalling axis. PIK3CB may be a potential target in ESCC.
Biology of macrophage fate decision: Implication in inflammatory disorders
Authors: Yadav Sarika , Dwivedi Ashish , Tripathi Anurag 
Published: July 2022

AbstractThe activation of immune cells in response to stimuli present in their microenvironment is regulated by their metabolic profile. Unlike the signal transduction events, which overlap to a huge degree in diverse cellular processes, the metabolome of a cell reflects a more precise picture of cell physiology and function. Different factors governing the cellular metabolome include receptor signaling, macro and micronutrients, normoxic and hypoxic conditions, energy needs, and biomass demand. Macrophages have enormous plasticity and can perform diverse functions depending upon their phenotypic state. This review presents recent updates on the cellular metabolome and molecular patterns associated with M1 and M2 macrophages, also termed “classically activated macrophages” and “alternatively activated macrophages,” respectively. M1 macrophages are proinflammatory in nature and predominantly Th1‐specific immune responses induce their polarization. On the contrary, M2 macrophages are anti‐inflammatory in nature and primarily participate in Th2‐specific responses. Interestingly, the same macrophage cell can adapt to the M1 or M2 phenotype depending upon the clues from its microenvironment. We elaborate on the various tissue niche‐specific factors, which govern macrophage metabolism and heterogeneity. Furthermore, the current review provides an in‐depth account of deregulated macrophage metabolism associated with pathological disorders such as cancer, obesity, and atherosclerosis. We further highlight significant differences in various metabolic pathways governing the cellular bioenergetics and their impact on macrophage effector functions and associated disorders.
Novel targets to overcome antiangiogenesis therapy resistance in glioblastoma multiforme: Systems biology approach and suggestion of therapy by galunisertib
Authors: Hadizadeh Morteza , AminJafari Akram , Parvizpour Sepideh , Ghasemi Sorayya 
Published: July 2022

AbstractGlioblastoma multiforme (GBM) is a tumor with high microvessel density. Antiangiogenesis therapy (AAT) resistance occurs due to the complex mechanisms involved in angiogenesis, with increased chances of recurrence. The vascular endothelial growth factor (VEGF) pathway is the main pathway of angiogenesis, and anti‐VEGF drugs have been ineffective in controlling it. New oncogenes in the VEGF signaling pathway may be new candidates for angiogenesis targeting. Oncogene candidates were chosen using gene expression profiles and databases. Then oncogenes were subjected to gene set enrichment analysis (GSEA) and survival analysis (SA). Molecular docking was conducted to evaluate the interaction of the oncogenes with galunisertib. NRAS, AKT1, and HSPB1 were the most effective oncogenes upregulating genes that play a role in GBM expression in the VEGF signaling pathway. The VEGF and MAPK signaling pathways were found to be effective using GSEA and Kyoto Encyclopedia Gene and Genome pathway analysis. Survival analyses revealed that patients with high HSPB1 expression had poorer overall survival rates than those with low HSPB1 expression. Galunisertib exhibits intermolecular interactions with 6DV5, 5UHV, and 3O96 (binding energy −8.0, −8.6, and −10.3 kcal/mol, respectively). The current AAT should be restrategized to suppress the numerous angiogenic elements to manage angiogenesis and combat AAT resistance in GBM. In silico analysis indicated that NRAS, AKT1, and HSPB1 genes can be the main oncogenes in the VEGF signaling pathway and galunisertib strongly interacts with these genes. Consequently, the use of galunisertib to overcome AAT in GBM in combination therapy can be assessed.
Left atrial appendage closure with the II generation Ultraseal device: An international registry. The LIGATE study
Authors: Pivato Carlo A. , Liccardo Gaetano , Sanz‐Sanchez Jorge , Pelloni Elisa , Pujdak Krzysztof , Xuareb Robert G. , Cruz‐Gonzalez Ignacio , Pisano Francesco , Scotti Andrea , Tarantini Giuseppe , Cook Stephane , Regazzoli Damiano , Reimers Bernhard , Condorelli Gianluigi , Bragato Renato Maria , Stefanini Giulio G. , Pagnotta Paolo 
Published: July 2022

AbstractObjectivesTo assess feasibility and safety of second‐generation left atrial appendage closure (LAAC) Ultraseal device in patients with nonvalvular atrial fibrillation (NVAF).BackgroundLAAC with first‐generation Ultraseal device (Cardia, Eagan, Minnesota) has been shown to be a feasible therapeutic option in patients with NVAF. However, there is a paucity of data regarding the novel second‐generation Ultraseal device.MethodsAll patients with NVAF undergoing second‐generation Ultraseal device implantation between February 2018 and September 2020 were included in a multicenter international registry. Periprocedural and post‐discharge events were collected through 6‐month follow‐up. Co‐primary efficacy endpoints were device success and technical success while primary safety endpoint was in‐hospital major adverse event (MAE) occurrence.ResultsA total of 52 patients were included: mean age 75 ± 8, 30.8% women, mean HAS‐BLED 3 ± 1. The device was successfully implanted in all patients. Technical success was achieved in 50 patients (96.1%). In‐hospital MAEs occurred in three patients (5.8%). The incidence of 6‐month all‐cause death and major bleeding was 11.6% and 2.1%, respectively. No strokes, transient ischemic attacks, systemic embolisms, or device embolization were reported after discharge.ConclusionsSecond‐generation Ultraseal device implantation was associated with high success rates and a low incidence of peri‐procedural complications. Larger studies with longer follow‐up are warranted to further evaluate the safety and the efficacy of this device, especially at long‐term follow‐up.
In‐hospital outcomes of TAVR patients with a bundle branch block: Insights from the National Inpatient Sample 2011–2018
Authors: Zahid Salman , Khan Muhammad Z. , Ullah Waqas , Tanveer Ud Din Mian , Abbas Sakina , Ubaid Aamer , Khan Muhammad U. , Rai Devesh , Baibhav Bipul , Rao Mohan , Singla Atul , Goldsweig Andrew M. , Depta Jeremiah P. , Balla Sudarshan 
Published: July 2022

AbstractIntroductionData on the outcomes following transcatheter aortic valve replacement (TAVR) in patients with a bundle branch block (BBB) remains limited.MethodsWe studied the outcomes of TAVR patients with a BBB from the National Inpatient Sample (NIS) database between 2011 and 2018 using ICD‐9‐CM and ICD‐10‐CM codes.ResultsBetween 2011 and 2018, 194,237 patients underwent TAVR, where 1.7% (n = 3,232) had a right BBB (RBBB) and 13.7% (n = 26,689) had a left BBB (LBBB). Patients with a RBBB and LBBB had a higher rate of new permanent pacemaker (PPM) implantation (31.5% ‐ RBBB, 15.7% LBBB vs. 10.2% ‐ no BBB). RBBB was associated with a significantly longer median length of stay (5 days) and total hospitalization cost ($53,669) compared with LBBB (3 days and $47,552) and no BBB (3 days and $47,171). Trend analysis revealed lower rates of PPM implantation and reduced lengths of stay and costs across all comparison groups.ConclusionIn conclusion, patients undergoing TAVR with a BBB are associated with higher new rates of PPM implantation. RBBB is the strongest independent predictor for new PPM implantation following TAVR. Rates of new PPM implantation in TAVR patients with and without a BBB have improved over time including reductions in length of stay and hospital costs. Further study is needed to reduce the risks of PPM implantation in TAVR patients.
Performance characteristics of an axial‐flow gas induction impeller
Authors: Hoffman Shannon M. , Janz Eric E. , Myers Kevin J. , Brown Nicholas A. 
Published: July 2022

AbstractPower number, pressure coefficient, and induced gas flow rate of a novel axial‐flow gas induction impeller with large openings for gas flow are reported. The effects of rotational speed, impeller diameter, submergence, and pumping mode are considered in turbulent operation. The pressure coefficient is measured using the reduction in pressure at speeds below the minimum induction speed as well as from the minimum induction speed. The minimum induction speed approach consistently yields lower pressure coefficient values, indicating the existence of impeller exit losses that are required to force gas from the centre of the impeller into the liquid. The induced gas flow rate is modelled using two approaches. The first approach relates the gas flow rate to the available pressure difference, and in this case, the relation is found to be strongly affected by impeller diameter. The second approach is a literature model that likens the induction process to water jet injection. While this approach appears promising, flow measurement device pressure losses make it difficult to definitively evaluate this method.