bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous determination of five poppy husk alkaloids and three main components of acetaminophen‐caffeine‐aspirin tablets in hot pot broth by ultra‐high‐performance liquid chromatography–tandem mass spectrometry
Authors: Song Juan , Guo Tianrong , Wu Wenlin , Liao Mei , Xiao Quanwei , Qiao Binzong , Wan Yuping , Dai Qin , Zhou Yan 
Published: November 2022

AbstractThis work aimed to evaluate the usefulness of ultra‐high‐performance liquid chromatography coupled with mass spectrometry for the simultaneous determination of five alkaloids and three main components of acetaminophen‐caffeine‐aspirin tablets in hot pot broth. The sample was extracted by hydrochloric acid (0.1 mol) and sodium hydroxide was used to adjust the potential of hydrogen. Then acetonitrile was used to extract the target compounds and cleaned up by one enhanced matrix removal product. Standard curves were made by adding mixing standard solutions of different concentrations. Eight isotope internal standards were used to improve the accuracy of the quantification. The linear ranges were 0.4–40.0 μg/kg for morphine, codeine, acetaminophen, caffeine, and salicylic acid, as well as 0.08–8.0 μg/kg for thebaine, papaverine, and noscapine, respectively. The eight compounds had good linearities and the detection limits of were in the range of 0.003–0.3 μg/kg. The recovery values were higher than 82% and the precision was lower than 14.7% in the experiment. A lot of actual testing of hot pot broth samples showed that the method is simple, effective, and sensitive, which is suitable for the determination and confirmation of the eight targeted compounds added to the hot pot broth.
Liquid chromatography‐tandem mass spectrometry method for simultaneous assessment of ofloxacin and dexamethasone in ocular biofluids: Application to ocular pharmacokinetic studies
Authors: Sanap Sachin Nashik , Bisen Amol Chattrapati , Agrawal Sristi , Biswas Arpon , Mishra Anjali , Kumar Mukesh , Verma Sarvesh Kumar , Chaudhary Abhijit Deb , Bhatta Rabi Sankar 
Published: November 2022

AbstractA simple, fast, and responsive liquid chromatography‐tandem mass spectrometry method was established and fully validated according to the United States Food and Drug Administration guidelines for the simultaneous quantitation of ofloxacin and dexamethasone in tear fluid and partially in aqueous humor and cornea. Samples were cleaned‐ up by single‐step precipitation using methanol as an anti‐solvent. Agilent SB C18 column with 4.5 min total run time was used for chromatographic separation utilizing isocratic mode. Mass spectrometry detection was carried out by a triple quadrupole tandem mass spectrometer in the multiple reaction monitoring modes utilizing a positive electrospray ionization. The developed method showed a wide analytical range (ofloxacin: 0.7812–200 ng/ml and dexamethasone: 1.875–240 ng/ml) with good linearity (r2 > 0.99) and acceptable accuracy and precision. It also showed excellent recoveries (>85% for analytes) and a negligible matrix effect. Finally, this method was successfully applied to determine the pharmacokinetic profile of clinically used eye drop solution of ofloxacin and dexamethasone in preclinical rabbit tear fluid, suggesting its suitability for therapeutic drug monitoring in clinical practices.
Long‐term outcome with neoadjuvant electrochemotherapy and sliding canthoplasty in a cat with locally advanced squamous cell carcinoma of the lower and third eyelid
Authors: Ferro Livia , Rigon Niccolò , Ciccarelli Stefano , Barachetti Laura , Leo Chiara 
Published: November 2022

AbstractA 10‐year‐old, female, spayed cat was referred with a lower eyelid mass lesion of the right eye. Fine‐needle aspiration cytology and histopathology revealed a locally advanced squamous cell carcinoma. The cat was treated with three sessions of neoadjuvant electrochemotherapy, which was associated with a good response. After electrochemotherapy treatment, a sliding canthoplasty was performed to reconstruct the eyelid margin. Histology of excised tissue during surgery, post‐electrochemotherapy, demonstrated a lack of neoplastic cells. The patient was still in complete remission 22 months after diagnosis. All treatments were well tolerated, with mild‐to‐moderate and self‐limiting local toxicities, allowing normal eyelid function and preservation of sight. This multi‐modal approach resulted in a long‐term local control. This case report highlights the potential benefit of electrochemotherapy in the neoadjuvant setting, enabling surgical removal and long‐term local tumour control.
Accelerated computation of the genetic algorithm for energy-efficient virtual machine placement in data centers
Authors: Ding Zhe , Tian Yu-Chu , Wang You-Gan , Zhang Wei-Zhe , Yu Zu-Guo 
Published: November 2022

AbstractEnergy efficiency is a critical issue in the management and operation of cloud data centers, which form the backbone of cloud computing. Virtual machine (VM) placement has a significant impact on energy-efficiency improvement for virtualized data centers. Among various methods to solve the VM-placement problem, the genetic algorithm (GA) has been well accepted for the quality of its solution. However, GA is also computationally demanding, particularly in the computation of its fitness function. This limits its application in large-scale systems or specific scenarios where a fast VM-placement solution of good quality is required. Our analysis in this paper reveals that the execution time of the standard GA is mostly consumed in the computation of its fitness function. Therefore, this paper designs a data structure extended from a previous study to reduce the complexity of the fitness computation from quadratic to linear one with respect to the input size of the VM-placement problem. Incorporating with this data structure, an alternative fitness function is proposed to reduce the number of instructions significantly, further improving the execution-time performance of GA. Experimental studies show that our approach achieves 11 times acceleration of GA computation for energy-efficient VM placement in large-scale data centers with about 1500 physical machines in size.
Combined synoptic and regional weather patterns affecting atmospheric Poaceae pollen concentrations in Sydney, Australia
Authors: Waudby Charlotte M. , Sherwood Steven C. , Osborne Nicholas J. , Beggs Paul J. , Al-Kouba Jane , Ebert Elizabeth E. , Muscatello David J. 
Published: November 2022

AbstractInhalation of grass pollen can result in acute exacerbation of asthma, prompting questions about how grass pollen reaches metropolitan areas. We establish typical atmospheric Poaceae (grass) pollen concentrations recorded at two pollen samplers within the Sydney basin in eastern Australia and analyse their correlation with each other and meteorological variables. We determine the effect of synoptic and regional airflow on Poaceae pollen transport during a period of extreme (≥ 100 grains m−3 air) concentration and characterise the meteorology. Finally, we tested the hypothesis that most Poaceae pollen captured by the pollen samplers originated from local sources. Fifteen months of daily pollen data, three days of hourly atmospheric Poaceae pollen concentrations and fifteen months of hourly meteorology from two locations within the Sydney basin were used. Weather Research Forecasting (WRF), Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) modelling and conditional bivariate probability functions (CBPF) were used to assess Poaceae pollen transport. Most Poaceae pollen collected was estimated to be from local sources under low wind speeds. Extreme daily Poaceae pollen concentrations were rare, and there was no strong evidence to support long-distance Poaceae pollen transport into the Sydney basin or across the greater Sydney metropolitan area. Daily average pollen concentrations mask sudden increases in atmospheric Poaceae pollen, which may put a significant and sudden strain on the healthcare system. Mapping of Poaceae pollen sources within Sydney and accurate prediction of pollen concentrations are the first steps to an advanced warning system necessary to pre-empt the healthcare resources needed during pollen season.
Global weak solutions to a phase-field model for motion of grain boundaries
Authors: Zhu Zixian , Guo Boling , Fang Shaomei 
Published: November 2022

AbstractWe employ the Galerkin method to prove the global existence of weak solutions to a phase-field model which is suitable to describe a sort of interface motion driven by configurational forces. The higher-order derivative of unknown S exists in the sense of local weak derivatives since it may be not summable over the original open domain. The existence proof is valid in the one-dimensional case.
Thermoelectric field for a coated hole of arbitrary shape in a nonlinearly coupled thermoelectric material
Authors: Wang Xu , Schiavone P. 
Published: November 2022

AbstractWe study the thermoelectric field for an electrically and thermally insulated coated hole of arbitrary shape embedded in an infinite nonlinearly coupled thermoelectric material subject to uniform remote electric current density and uniform remote energy flux. A conformal mapping function for the coating and matrix is introduced, which simultaneously maps the hole boundary and the coating-matrix interface onto two concentric circles in the image plane. Using analytic continuation, we derive a general solution in terms of two auxiliary functions. The general solution satisfies the insulating conditions along the hole boundary and all of the continuity conditions across the perfect coating-matrix interface. Once the two auxiliary functions have been obtained in the elementary-form, the four original analytic functions in the coating and matrix characterizing the thermoelectric fields are completely and explicitly determined. The design of a neutral coated circular hole that does not disturb the prescribed thermoelectric field in the thermoelectric matrix is achieved when the relative thickness parameter and the two mismatch parameters satisfy a simple condition. Finally, the neutrality of a coated circular thermoelectric inhomogeneity is also accomplished.
A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia
Authors: Powell Mark , Fuller Sophia , Gunderson Erica , Benz Christopher 
Published: November 2022

Abstract
Purpose
Preeclampsia has been inconsistently associated with altered later life risk of cancer. This study utilizes the Nurses’ Health Study 2 (NHS2) to determine if the future risk of breast and non-breast cancers in women who experience preeclampsia is modified by carrying a protective variant of rs2016347, a functional insulin-like growth factor receptor-1 (IGF1R) single nucleotide polymorphism.

Methods
This retrospective cohort study completed within the NHS2 evaluated participants enrolled in 1989 and followed them through 2015, with a study population of 86,751 after exclusions. Cox proportional hazards models both with and without the impact of rs2016347 genotype were used to assess the risk of invasive breast cancer, hormone receptor-positive (HR+) breast cancer, and non-breast cancers.

Results
Women with preeclampsia had no change in risk of all breast, HR+ breast, or non-breast cancers when not considering genotype. However, women carrying at least one T allele of rs2016347 had a lower risk of HR+ breast cancer, HR 0.67, 95% CI: 0.47–0.97, P = 0.04, with interaction term P = 0.06. For non-breast cancers as a group, women carrying a T allele had an HR 0.76, 95% CI: 0.53–1.08, P = 0.12, with interaction term P = 0.26.

Conclusions
This retrospective cohort study found that women with preeclampsia who carry a T allele of IGF1R rs2016347 had a reduced future risk of developing HR+ breast cancer, and a reduced but not statistically significant decreased risk of non-breast cancers suggesting a possible role for the IGF-1 axis in the development of cancer in these women.
Quality assessment of cardiac magnetic resonance myocardial scar imaging prior to ventricular arrhythmia ablation
Authors: Shah Rushil , Sharma Apurva , Assis Fabrizio , De Vasconcellos Henrique Doria , Alugubelli Navya , Pandey Pallavi , Akhtar Tauseef , Gasperetti Alessio , Zhou Shijie , Halperin Henry , Zimmerman Stefan L. , Tandri Harikrishna , Kolandaivelu Aravindan 
Published: November 2022

AbstractHigh-resolution scar characterization using late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR) is useful for guiding ventricular arrhythmia (VA) treatment. However, imaging study quality may be degraded by breath-holding difficulties, arrhythmias, and implantable cardioverter-defibrillators (ICDs). We evaluated the effect of image quality on left ventricle (LV) base to apex scar interpretation in pre-VA ablation LGE-CMR. 43 consecutive patients referred for VA ablation underwent gradient-recalled-echo LGE-CMR. In ICD patients (n = 24), wide-bandwidth inversion-recovery suppressed ICD artifacts. In non-ICD patients, single-shot steady-state free-precession LGE-CMR could also be performed to reduce respiratory motion/arrhythmia artifacts. Study quality was assessed for adequate/limited scar interpretation due to cardiac/respiratory motion artifacts, ICD-related artifacts, and image contrast. 28% of non-ICD patients had studies where image quality limited scar interpretation in at least one image compared to 71% of ICD patient studies (p = 0.012). A median of five image slices had limited quality per ICD patient study, compared to 0 images per non-ICD patient study. Poorer quality in ICD patients was largely due to motion-related artifacts (54% ICD vs 6% non-ICD studies, p = 0.001) as well as ICD-related image artifacts (25% of studies). In VA ablation patients with ICDs, conventional CMR protocols frequently have image slices with limited scar interpretation, which can limit whole-heart scar assessment. Motion artifacts contribute to suboptimal image quality, particularly in ICD patients. Improved methods for motion and ICD artifact suppression may better delineate high-resolution LGE scar features of interest for guiding VA ablation.
Oral formulation of bendamustine hydrochloride for patients with advanced solid tumors; a phase 1 study
Authors: Shimizu Toshio , Nakagawa Kazuhiko , Hayashi Hidetoshi , Iwasa Tsutomu , Kawakami Hisato , Watanabe Satomi , Yamamoto Noboru , Yonemori Kan , Koyama Takafumi , Sato Jun , Tamura Kenji , Kikuchi Keiichi , Akaike Kenichiro , Takeda Shiho , Takeda Masayuki 
Published: November 2022

SummaryTo determine the maximum tolerated dose (MTD) and recommended dose (RD) of orally-administered bendamustine in Japanese patients with advanced solid tumors. The optimal dosing schedule, safety, pharmacokinetics, and preliminary antitumor effects were also evaluated. A multicenter, open-label trial with a standard 3 + 3 design and dose escalation by dose-limiting toxicity (DLT) was conducted. The treatment schedules were once daily for 7, 14, and 21 days every 3 weeks as one cycle. The total dose per cycle was increased from 175 to 840 mg/m2. Eighteen patients were enrolled in this study. DLT occurred in one of six patients at 75 mg/m2/day × 7 days, and one of three patients at 37.5 mg/m2/day × 14 days and 25 mg/m2/day × 21 days. However, the delayed recovery from a decrease in neutrophil or platelet count hampered the start of subsequent treatment cycles, and the trend was more prominent at 37.5 mg/m2/day × 14 days and 25 mg/m2/day × 21 days than in 75 mg/m2/day × 7 days. MTD was determined as 75 mg/m2/day × 7 days to allow acceptable hematologic recovery. The pharmacokinetics of orally-administered bendamustine were generally dose-dependent; however, the inter-individual variability is relatively large. The major adverse events were hematologic toxicities; gastrointestinal disorders were generally mild. Adverse drug reactions did not lead to the discontinuation of the drug. A partial response was observed in two of six patients (prostatic small cell carcinoma and thymic carcinoma) at 75 mg/m2/day × 7 days. The RD and optimal dosing schedule of orally-administered bendamustine was 75 mg/m2 once daily for 7 days every 3 weeks for the treatment of advanced solid tumors. (Trial registration number ClinicalTrials.gov NCT03604679. Registration date July 27, 2018).
Comparison of the efficacy of acupuncture at the TUNG’s extra points and the traditional Chinese medicine points for elderly patients with chronic low back pain in Thailand
Authors: Siriteerathitikul Poonyaphat , Wongmanakul Saengchai , Kunyalue Monticha , Khamthai Punyawee 
Published: November 2022

Abstract
Objective
To compare the efficacy of acupuncture at TUNG’s extra points and traditional Chinese medicine (TCM) points for elderly patients with chronic low back pain (CLBP) in Thailand.

Methods
A single-blinded, randomized controlled trial with 84 elderly volunteers with CLBP was designed. The patients were randomly assigned either to the group getting acupuncture at TUNG’s extra points or to the group getting acupuncture at TCM points. The treatment period was 30 min per session for seven consecutive days. Before and after treatment, the score of the numeric rating scale (NRS), the back range of motion (BROM), and the back strength were measured and compared.

Results
After treatment, both groups were found with decreased NRS scores and increased BROM (P<0.05), but with no statistical difference in their back strength in comparison with that before treatment in the same group (P>0.05). Regarding the between-group comparisons, no significant differences were found in the NRS score or BROM in the direction of forward flexion and right lateral flexion or the back strength after treatment (P>0.05). However, statistical differences were found in the BROM in directions of back extension (P<0.01) and left lateral flexion (P<0.05).

Conclusion
Acupuncture at TUNG’s extra points can decrease the low back pain NRS score and increase the back strength and the BROM in directions of forward flexion and right lateral flexion, equivalent to acupuncture at TCM points. Acupuncture at TCM points has a better effect in increasing the BROM in directions of back extension and left lateral flexion; acupuncture at TUNG’s extra points is suitable for elderly CLBP patients, and it should be supported and promoted.
Retrospective analyses on preputioplasties in boys with pathological phimosis performed over the last nine years
Authors: Bosveld Jikke , Hornung Paul , Klijn Aart J. , Schroeder Rogier P. J. 
Published: November 2022

AbstractIn our clinic, more patients wish to treat pathological phimosis with a preputioplasty to preserve their foreskin. This study aims to analyze the long-term effects of preputioplasty. Additionally, we have produced an instructional video for those who want to master this surgical technique. A retrospective cohort study was performed in boys aged ≤ 18 years old suffering from pathological phimosis. All patients underwent preputioplasty between January 2011–2020. The outcome of the preputioplasty is considered positive when the foreskin was retractable months post-operative.In total, 176 patients were included. The mean age operating was 8.9 years. A positive result after preputioplasty was observed in 163/176 patients (93%). Patients with a negative outcome most often chose a re-operation: circumcision in seven cases and a redo-preputioplasty in three. Four patients showed complications (minor infection (1), wound dehiscence (2), and excess amount of skin (1)). Thus, a preputioplasty is shown to be a feasible operative treatment option.
Coupled Finite Element Simulation of Shape Memory Bending Microactuator
Authors: Tshikwand Georgino Kaleng , Seigner Lena , Wendler Frank , Kohl Manfred 
Published: November 2022

AbstractDue to their high-energy density, shape memory alloys (SMAs) are investigated as material for bending microactuators in applications of self-folding structures, realizing the concept of programmable matter. Here, for the numerical prediction of the electro-thermo-mechanical performance, the quantification of the time-dependent coupling effects in SMA materials during phase transformation is of crucial interest. Isothermal SMA material models cannot treat the time-dependent interaction between deformation, temperature and electric potential in thermally controlled actuation. In this paper, we extend an isothermal SMA model using standard thermodynamics (Coleman–Noll procedure) to treat the time-dependent behavior of polycrystalline SMAs. The model is implemented as a user material subroutine (UMAT) in a standard finite element (FE) code (Abaqus standard). The time-dependent loading of a tensile sample and a bending microactuator made from 20 $$\mu \hbox {m}$$

μ
m

thick SMA foil are simulated. A comparative study between experimental and simulation results on the thermoelastic and caloric effects during stress-induced phase transformation is presented. Joule heating simulations for shape recovery during both tensile and bending loading are conducted. Time-resolved temperature variations accompanying the loading and Joule heating processes are reported. The coupled SMA material model is found to be capable of approximating the time-dependent field quantities of a polycrystalline SMA microactuator subjected to electro-thermo-mechanical loading.
Chaos Analysis of Single-Stage Spur Gear System Considering Backlash Fractal
Authors: Yu Jiahui , Wang Huiyuan , Ren Dongdong 
Published: November 2022

AbstractPurposeConsidering the time-varying pressure angle and dynamic clearance, the effects of rotational speed, tooth surface friction, and tooth surface morphology on the system’s dynamic response are studied.MethodAn improved gear nonlinear model is proposed, which considered nonlinear factors such as time-varying pressure angle, position angle, tooth surface morphology, and tooth surface friction. The time-varying dynamic backlash is deduced, and the nonlinear dynamic equation of the gear is established. The nonlinear dynamic response of the gear system is obtained based on Runge–Kutta method.ResultsThe influence of the rotational speed and tooth surface friction on single-stage spur gear system response is analyzed through the analysis of the bifurcation diagram, the three-dimensional spectrum diagram, the proportion of the meshing state, and the largest dynamic meshing force (LDMF). Dynamic response differences between the three different model are compared. In addition, by changing the tooth surface roughness and fractal dimension, the influence of tooth surface morphology on the dynamic response of the system is studied.ConclusionCompared with the traditional model, when the dynamic center distance and dynamic pressure angle are considered, the system response may enter a chaotic state earlier. When the tooth surface friction is further considered, the chaotic state of the system response is suppressed. At the same time, the velocity of the dynamic transmission error is significantly reduced, and the fluctuation amplitude of the dynamic pressure angle is increased. The value of LDMF rose overall. The stability of the system response decreases with the increase of tooth surface roughness and fractal dimension. Compared with the fractal dimension, the tooth surface roughness has a more obvious effect on the dynamic response of the system.