bluuebunny/crossref_metadata_2025_split huggingface dataset:
Het Probleem van de Traditie te Montreal
Authors: Tavard A.A. G. 
Published: October 2022

Le problème de la Tradition à Montréal
Parmi Jes problèmes théologiques, agités à Montréal, le thème „la Tradition et les Traditions” est incontestablement celui qui a retenu le plus l’attention. Ceci pour plusieurs raisons. Ce sujet est de ceux dont l’actualité est évidente en raison des controverses des deux dernières décades, de l’intérêt que lui porte le deuxième Concile du Vatican, et de la portée oecuménique du problème. Par ailleurs, sur ce sujet les travaux de Foi et Constitution à Montréal paraissent être plus satisfaisants que sur Jes autres.
La Commission Théologique à reçu en 1954 cet objet d’étude. En fait deux commissions furent formées, l’une en Europe, l’autre en Amérique du Nord. L’orientation de la commission européenne sous la présidence du théologien luthérien danois K. E. Skydsgaard devait devenir plus théologique, alors que celle de la commission américaine, présidée par l’initiateur du projet primitif, le professeur A. C. Outler, s’efforcerait de jeter les bases d’une historiographie oecuménique.
Après avoir étudié les rapports intérimaires des commissions et les décisions de la réunion du comité directeur de Foi et Constitution à Paris (1962), l’auteur étudie le rapport final des deux commissions, dont l’analyse montre d’une part la valeur des conclusions, et d’autre part la difficulté de prendre ces conclusions comme point de départ des travaux de Montréal.
Dans la dernière partie de l’article est étudié le texte final du document, élaboré à Montréal.
Le problème à peine traité de la tradition comme transmission ne présente pas de difficulté fondamentale aux membres orthodoxes du Conseil Oecuménique. Il n’en est pas de même du Protestantisme. Tant que la Tradition est indentifiée à l’Evangile, elle cadre parfaitement avec la théologie protestante classique; elle correspond également aux tendances modernes de l’éxègese bultmannienne. Mais le problème de la Tradition comme transmission à été, jusqu’à présent, étranger au Protestantisme: il soulève en effet toutes les questions pendantes entre l’Eglise Catholique et les Réformés. La question de la Tradition comme transmission du message oblige à revoir les principes fondamentaux de la Réforme protestante. La commission „Foi et Constitution” à eu l’immense mérite d’aborder la question. La Conférence de Montréal a eu celui de préciser le lieu de la question: entre l’Evangile-Tradition et les traditions humaines, il y a la tradition historique de l’Eglise. Quelle est-elle et où va-t-elle restent Jes questions non résolues du rapport de Montréal.
Human impact on the recent population history of the elusive European wildcat inferred from whole genome data
Authors: Nieto-Blázquez María Esther , Schreiber Dennis , Mueller Sarah A. , Koch Katrin , Nowak Carsten , Pfenninger Markus 
Published: October 2022

AbstractBackgroundThe extent and impact of evolutionary change occurring in natural populations in response to rapid anthropogenic impact is still poorly understood on the genome-wide level. Here, we explore the genetic structure, demographic history, population differentiation, and domestic introgression based on whole genome data of the endangered European wildcat in Germany, to assess potential genomic consequences of the species’ recent spread across human-dominated cultural landscapes.ResultsReconstruction of demographic history and introgression rates based on 47 wildcat and 37 domestic cat genomes suggested late introgression between wild and domestic cat, coinciding with the introduction of domestic cat during the Roman period, but overall relatively low rates of hybridization and introgression from domestic cats. Main population divergence found between an eastern and central German wildcat clade was found to be of rather recent origin (200 y), and thus the likely consequence of anthropogenic persecution and resulting isolation in population refugia. We found similar effective population sizes and no substantial inbreeding across populations. Interestingly, highly differentiated genes between wild cat populations involved in the tryptophan-kynurenine-serotonin pathway were revealed, which plays a role in behavioral processes such as stress susceptibility and tolerance, suggesting that differential selection acted in the populations.ConclusionsWe found strong evidence for substantial recent anthropogenic impact on the genetic structure of European wildcats, including recent persecution-driven population divergence, as well as potential adaptation to human-dominate environments. In contrast, the relatively low levels of domestic introgression and inbreeding found in this study indicate a substantial level of “resistance” of this elusive species towards major anthropogenic impacts, such as the omnipresence of domestic cats as well as substantial habitat fragmentation. While those findings have strong implications for ongoing conservation strategies, we demand closer inspection of selective pressures acting on this and other wildlife species in anthropogenic environments.
The acceptability of asking women to delay removal of a long-acting reversible contraceptive to take part in a preconception weight loss programme: a mixed methods study using qualitative and routine data (Plan-it)
Authors: Channon Susan , Coulman Elinor , Cannings-John Rebecca , Henley Josie , Lau Mandy , Lugg-Widger Fiona , Strange Heather , Davies Freya , Sanders Julia , Scherf Caroline , Couzens Zoe , Morantz Leah 
Published: October 2022

Abstract
Background
Having a body mass index (BMI) which is classified as overweight (BMI ≥ 25) or obese (BMI ≥ 30) increases the risk of complications during pregnancy and labour. Weight-management interventions which target excess gestational weight gain during pregnancy have had limited success. Women who use long-acting reversible contraception (LARC) are in contact with services as part of their preparation for conception, creating a potential opportunity to offer a preconception weight-loss intervention.
The aims of this mixed methods study were to assess the acceptability and practicability of a weight-loss intervention which asked people to delay LARC removal in order to lose weight before conceiving.

Methods
Routine UK NHS data were analysed to identify pathways from LARC removal to pregnancy. Qualitative surveys and advisory group discussions with service providers and LARC users with experience of being overweight were conducted and analysed thematically.

Results
Three hundred fifteen thousand seven hundred fifty-five UK women aged 16–48 years between 2009–2018 had at least one LARC-related event (e.g. insertion, removal) and 1.7% of those events were recorded as related to planning a pregnancy. BMI was included in 62% of women’s records, with 54% of those BMI being classified as overweight or obese. Online surveys were completed by 100 healthcare practitioners and 243 LARC users. Stakeholders identified facilitators and barriers associated with the proposed intervention including sensitivities of discussing weight, service-user past experiences, practitioner skills, the setting and ethical implications of the proposed intervention.

Conclusions
Although women and service providers recognised potential benefits, a preconception weight-loss intervention asking people to delay LARC removal posed many barriers, due mainly to the acceptability of such an intervention to women and healthcare practitioners. Weight-loss interventions that target the general population, together with a focus on improving public knowledge of preconception health, may be more acceptable than interventions which solely focus on LARC users. Many of the barriers identified, including communication, understanding and beliefs about weight and risk, appointment systems and the limitations of routine datasets also have relevance for any preconception weight-loss intervention. Work to improve routine datasets and reducing communication barriers to discussing weight are priorities.

Trial registration
ISRCTN14733020 registered 10.05.2019.
RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage
Authors: Haynes Brittany M. , Cunningham Kristen , Shekhar Malathy P. V. 
Published: October 2022

Abstract
Background
Paclitaxel (PTX), a first-line therapy for triple negative breast cancers (TNBC) induces anti-tumor activity by microtubule stabilization and inhibition of cell division. Its dose-limiting toxicity and short half-life, however, pose clinical challenges underscoring the need for strategies that increase its efficiency. RAD6, a E2 ubiquitin conjugating enzyme, is associated with centrosomes at all phases of cell cycle. Constitutive overexpression of the RAD6B homolog in normal breast cells induces centrosome amplification and multipolar spindle formation, indicating its importance in centrosome regulation.

Methods
TNBC centrosome numbers were scored by pericentrin immunostaining. PTX sensitivities and interactions with SMI#9, a RAD6-selective small molecule inhibitor, on TNBC cell survival were analyzed by MTT and colony forming assays and an isogenic MDA-MB-468 TNBC model of PTX resistance. The molecular mechanisms underlying PTX and SMI#9 induced cytotoxicity were determined by flow cytometry, immunoblot analysis of cyclin B1 and microtubule associated protein TAU, and dual immunofluorescence staining of TAU and α-tubulin.

Results
Our data show aberrant centrosome numbers and that PTX sensitivities are not correlated with TNBC BRCA1 status. Combining PTX with SMI#9 synergistically enhances PTX sensitivities of BRCA1 wild-type and mutant TNBC cells. Whereas SMI#9/PTX combination treatment increased cyclin B1 levels in MDA-MB-468 cells, it induced cyclin B1 loss in HCC1937 cells with accumulation of reproductively dead giant cells, a characteristic of mitotic catastrophe. Cell cycle analysis revealed drug-induced accumulation of tetraploid cells in S and G2/M phases, and robust increases in cells with 4 N DNA content in HCC1937 cells. TAU overexpression is associated with reduced PTX efficacy. Among the six TAU isoforms, both SMI#9 and PTX downregulated 1N3R TAU in MDA-MB-468 and HCC1937 cells, suggesting a common mechanism of 1N3R regulation. Dual TAU and α-tubulin immunostaining showed that SMI#9 induces monopolar mitotic spindles. Using the isogenic model of PTX resistance, we show that SMI#9 treatment restores PTX sensitivity.

Conclusions
These data support a common mechanism of microtubule regulation by SMI#9 and PTX and suggest that combining PTX with RAD6 inhibitor may be beneficial for increasing TNBC sensitivities to PTX and alleviating toxicity. This study demonstrates a new role for RAD6 in regulating microtubule dynamics.
Willingness to pay for a group and an individual version of the Lifestyle-integrated Functional Exercise program from a participant perspective
Authors: Gottschalk Sophie , König Hans-Helmut , Schwenk Michael , Nerz Corinna , Becker Clemens , Klenk Jochen , Jansen Carl-Philipp , Dams Judith 
Published: October 2022

Abstract
Background
Perceived benefits of intervention programs from a participant perspective can be examined by assessing their willingness to pay (WTP). Aiming to support decision-makers in their decision to implement a fall prevention program, this study examined (1) the WTP for a group-based and an individually delivered fall prevention program, (2) which factors influence WTP, and (3) whether the WTP exceeds the intervention costs.

Methods
WTP was elicited using Payment Cards from 237 individuals who participated in a randomized non-inferiority trial (LiFE-is-LiFE) comparing a group version of the Lifestyle-integrated Functional Exercise program (gLiFE) with the individually delivered version (LiFE). Linear regression models were used to examine factors associated with WTP. The net benefit for (g)LiFE was calculated as the difference between WTP and intervention costs, assuming different scenarios of intervention costs (varying group sizes of gLiFE) and hypothetical subsidy levels by a payer (€0, €50, or €75).

Results
The mean WTP was €196 (95% CI [172, 221]) for gLiFE and €228 (95% CI [204, 251]) for LiFE. In the linear regression model, WTP was significantly associated with delivery format (−€32, 95% CI [− 65, − 0.2], for gLiFE) and net household income (+ 68€, 95% CI [23, 113], for ≥€3000 compared to <€2000). The net benefit for gLiFE was positive in most cases. Due to higher intervention costs of LiFE compared to gLiFE (€298 vs. €113), the net benefit for LiFE was negative for the majority of the sample, even at a subsidy of €75.

Conclusion
The results provide insight into how valuable the interventions are perceived by the participants and thereby may be used by decision-makers as complement to cost-effectiveness analyses. WTP for both programs was generally high, probably indicating that participants perceived the intervention as quite valuable. However, further research is needed on the WTP and net benefit of fall prevention programs, as results relied on the specific context of the LiFE-is-LiFE trial.
Classification of body postures using smart workwear
Authors: Lins Christian , Hein Andreas 
Published: October 2022

Abstract
Background
Despite advancing automation, employees in many industrial and service occupations still have to perform physically intensive work that may have negative effects on the health of the musculoskeletal system. For targeted preventive measures, precise knowledge of the work postures and movements performed is necessary.

Methods
Prototype smart work clothes equipped with 15 inertial sensors were used to record reference body postures of 20 subjects. These reference postures were used to create a software-based posture classifier according to the Ovako Working Posture Analysing System (OWAS) by means of an evolutionary training algorithm.

Results
A total of 111,275 posture shots were recorded and used for training the classifier. The results show that smart workwear, with the help of evolutionary trained software classifiers, is in principle capable of detecting harmful postures of its wearer. The detection rate of the evolutionary trained classifier ($$\bar{a}_{ccr} = 0.35$$

a

¯

ccr

=
0.35

for the postures of the back, $$\bar{a}_{ccr} = 0.64$$

a

¯

ccr

=
0.64

for the arms, and $$\bar{a}_{ccr} = 0.25$$

a

¯

ccr

=
0.25

for the legs) outperforms that of a TensorFlow trained classifying neural network.

Conclusions
In principle, smart workwear – as prototypically shown in this paper – can be a helpful tool for assessing an individual’s risk for work-related musculoskeletal disorders. Numerous potential sources of error have been identified that can affect the detection accuracy of software classifiers required for this purpose.
Exploring the psychological and religious perspectives of cancer patients and their future financial planning: a Q-methodological approach
Authors: Khan Kanwal Iqbal , Sabir Qurat ul An , Shafqat Ambreen , Aslam Muhammad 
Published: October 2022

Abstract
Background
Cancer patients are often hesitant to talk about their mental health, religious beliefs regarding the disease, and financial issues that drain them physically and psychologically. But there is a need to break this taboo to understand the perceptions and behaviours of the patients. Previous studies identified many psychological factors that are bothering cancer patients. However, it still requires exploring new elements affecting their mental and physical health and introducing new coping strategies to address patients’ concerns.

Methods
The current study aims to identify cancer patients’ perceived attitudes towards the severity of illness, understand their fears, tend towards religion to overcome the disease, and future financial planning by using a Q-methodological approach. Data were collected in three steps from January-June 2020, and 51 cancer patients participated in the final stage of Q-sorting.

Results
The findings of the study are based on the principal component factor analysis that highlighted three essential factors: (1) feelings, (2) religious beliefs about the acceptance of death, and (3) their future personal and financial planning. Further, the analysis shows that the patients differ in their beliefs, causes and support that they received as a coping mechanism.

Conclusion
This study explains cancer patients’ psychological discomfort and physical pain but cannot relate it to co-morbidities. Q methodology allows the contextualization of their thoughts and future planning in different sets, like acceptance of death, combating religion’s help, and sharing experiences through various platforms. This study will help health professionals derive new coping strategies for treating patients and financial managers to design insurance policies that help them to share their financial burdens.
A systematic review of strategies used for controlling consumer moral hazard in health systems
Authors: Koohi Rostamkalaee Zohreh , Jafari Mehdi , Gorji Hasan Abolghasem 
Published: October 2022

Abstract
Background
Consumer moral hazard refers to an increase in demand for health services or a decrease in preventive care due to insurance coverage. This phenomenon as one of the most evident forms of moral hazard must be reduced and prevented because of its important role in increasing health costs. This study aimed to determine and analyze the strategies used to control consumer moral hazards in health systems.

Methods
In this systematic review. Web of Sciences, PubMed, Scopus, Embase, ProQuest, Iranian databases(Magiran and SID), and Google Scholar engine were searched using search terms related to moral hazard and healthcare utilization without time limitation. Eligible English and Persian studies on consumer moral hazard in health were included, and papers outside the health and in other languages were excluded. Thematic content analysis was used for data analysis.

Results
Content analysis of 68 studies included in the study was presented in the form of two group, six themes, and 11 categories. Two group included “changing behavior at the time of receiving health services” and “changing behavior before needing health services.” The first group included four themes: demand-side cost sharing, health savings accounts, drug price regulation, and rationing of health services. The second approach consisted of two themes Development of incentive insurance programs and community empowerment.

Conclusion
Strategies to control consumer moral hazards focus on changing consumer consumptive and health-related behaviors, which are designed according to the structure of health and financing systems. Since “changing consumptive behavior” strategies are the most commonly used strategies; therefore, it is necessary to strengthen strategies to control health-related behaviors and develop new strategies in future studies. In addition, in the application of existing strategies, the adaptation to the structure of the health and financing system, and the pattern of consumption of health services in society should be considered.
Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients
Authors: Huang Zhixiang , Li Taiyuan , Zhang Genghua , Zhou Zhen , Shi Haoran , Tang Cheng , Yang Lingling , Lei Xiong 
Published: October 2022

Abstract
Background
Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to explore the advantage of robotic surgery in left colectomy by comparing open, laparoscopic, and robotic surgery.

Methods
A retrospective analysis was performed on the clinical data of patients with radical left colectomy for colon cancer who were admitted to the Department of General Surgery, The First Affiliated Hospital of Nanchang University, from November 2012 to November 2017. Two hundred eleven patients included were divided into the open surgery group (OS, n=49), laparoscopic surgery group (LS, n=92), and robotic surgery group (RS, n=70) according to surgical techniques. The clinicopathologic data were collected for clinical outcome assessment. Finally, the clinical value of RS in radical left colectomy was further evaluated by propensity score matching (PSM) analysis.

Results
Three groups were similar in demographics and clinical characteristics. Compared with OS, LS and RS groups had better intraoperative and perioperative clinical outcomes. Moreover, the RS group exhibited the minimum operative times, length of stay (LOS), and evaluated blood loss. LS and RS also exhibited less perioperative and postoperative long-term complications. Three groups showed similar postoperative pathological outcomes. The overall survival and disease-free survival were also similar among the three groups (all P > 0.05). Cox regression analysis showed surgical approach was not a prognostic factor for overall survival (P = 0.671) and disease-free survival (P = 0.776). PSM analysis of RS and LS by clinical characteristics showed RS showed shorter operation time (P < 0.001) and LOS for patients without complications (P = 0.005). However, no significant differences were found in perioperative and long-term postoperative complications, pathological outcomes, overall survival, and disease-free survival.

Conclusions
Among three techniques for radical left colectomy, LS and RS had significant advantages over OS in short-term clinical outcomes, and no significant differences were found in overall, disease-free survival, local recurrence, and distant metastasis incidence. Moreover, RS shows better perioperative clinical outcomes but without compromising survival compared with LS.
Editorial: Whither globalization and health in an era of geopolitical uncertainty?
Authors: Labonté Ronald , Martin Greg , Storeng Katerini T. 
Published: October 2022

AbstractGlobalization has been declared dead or dying for many years, although recently, the number of voices declaring it ‘over’ has swelled [1]. As editors of a journal interrogating how globalization affects health, we confront the question: Have the COVID-19 pandemic, Russia’s war against Ukraine, a breakdown in multilateralism, and the risk of a return to the stagflation of the 1970s finally sounded a death knell for the research and scholarship we have been publishing in the journal’s 20-year history? We think not and argue below why, in our post-pandemic fractured and fractious era, it is vitally important to retain a focus on this messy construct short-handed as ‘globalization.’
Iterative methods for vector equilibrium and fixed point problems in Hilbert spaces
Authors: Wang San-hua , Zhang Yu-xin , Huang Wen-jun 
Published: October 2022

AbstractIn this paper, algorithms for finding common solutions of strong vector equilibrium and fixed point problems of multivalued mappings are considered. First, a Minty vector equilibrium problem is introduced and the relationship between the Minty vector equilibrium problem and the strong equilibrium problem is discussed. Then, by applying the Minty vector equilibrium problem, projection iterative methods are proposed and some convergence results are established in Hilbert spaces. The main results obtained in this paper develop and improve some recent works in this field.