bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial genome of ‘numbfish’ Narcine timlei (Bloch &amp; Schneider, 1801) and phylogenetic relationships among order Torpediniformes
Authors: Kumar Amit , Prakash S. 
Published: June 2022

Abstract
Narcine timlei (Bloch & Schneider, 1801) is a medium-sized ray known to occur in inshore and offshore waters of the Indo-Pacific region, classified under the ‘vulnerable’ category of the IUCN Red List. This study reports, for the first time, the mitochondrial genome of N. timlei (average coverage ~ 60X) assembled from short Illumina reads 150 bp paired-ends reads. The mitogenome is 17,964 bp in length includes 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes. The gene order, size, and nucleotide compositions were found to be largely consistent with mitogenomic features of previously reported Narcine spp. However, the presence of a putative control region of 1,916 bp with three tandem repeats could be a reason for slightly larger mitogenome size than other Narcine spp. The phylogenetic reconstruction using concatenated PCGs (n = 13) of 9 Torpediniformes based on maximum likelihood and Bayesian inference analysis produced identical topologies. The tree showed two major clades, one clade having members of the family Narcinidae, and the second sister clade comprise of families Narkidae and Torpedinidae. Our result supports the monophyletic nature of Narcinidae based on mtDNA. The information obtained in this study will contribute to a better understanding of population genetics, phylogenetic analysis, conservation, and evolutionary biology research of N. timlei.
Citrus Flavonoids and Autoimmune Diseases: A Systematic Review of
Clinical Studies
Authors: Musumeci Laura , Maugeri Alessandro , Russo Caterina , Lombardo Giovanni Enrico , Cirmi Santa , Navarra Michele 
Published: June 2022

Background:
Autoimmune diseases are chronic disorders in which the immune system does not recognize and attacks one self’s healthy components. In this context, although natural remedies might represent a promising therapeutic strategy, evidence regarding Citrus flavonoids is still controversial.

Objective:
To summarize and critically discuss the clinical evidence on the effects of Citrus flavonoids for the management of autoimmune diseases.

Method:
A systematic review of articles has been carried out independently by two Authors using MEDLINE, Scopus and ISI Web of Science databases. Search terms comprised keywords related to Citrus flavonoids and autoimmune diseases. The last search was performed on March 16, 2021. No language restrictions were applied. Systematic review and study selection were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Before starting the review, Authors defined the types of articles to be included. Three reviewers independently carried out the extraction of papers.

Results:
Ten clinical studies fulfilled the eligibility criteria and were included in the final review.

Conclusion:
The studies discussed in this review are heterogeneous. Indeed, some studies suggest the use of Citrus flavonoids in the frame of autoimmune disorders, whereas others discourage it. Hence, this systematic review highlights the need of further large-scale clinical studies to define the exact role of Citrus flavonoids in the management of autoimmune diseases (PROSPERO number CRD42021234903).
An Overview on Immunity Booster Foods in Coronavirus Disease
(COVID-19)
Authors: Sahiba Nusrat , Sethiya Ayushi , Agarwal Dinesh K. , Agarwal Shikha 
Published: June 2022

Abstract:
The present COVID-19 pandemic is terrible for the respiratory system and is caused by
severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). It has affected millions of people
globally and over 511.9 million cases and 6.2 million deaths have been reported across the world.
Various drugs have been repurposed, however, no specific medicine has been approved by the
FDA to combat this disease till date. In this condition, researchers have been attracted to natural
and safe products to improve immunity to viral infections through inhibiting viral cell entry, replication,
and modulation. Various natural products, probiotics, and nutrients have antimicrobial, antiviral,
analgesic, anti-inflammatory, and antiproliferative activities, and some of the compounds
are also utilized in traditional medicine in Ayurveda, Siddha, and other cultures. This review provides
a clinical perspective on the application of herbs for the prevention of viral infections.
Arsenic Trioxide Restrains Lung Cancer Growth and Metastasis by Blocking
the Calcineurin-NFAT Pathway by Upregulating DSCR1
Authors: Yang Meng-Hang , Zhao Xue-Wei , Li Bing , Wang Yu-Sheng , Shi Xiao-Qian 
Published: June 2022

Background:
Anti-angiogenesis therapy mostly aimed at targeting vascular endothelial
growth factor (VEGF) and its receptors have been widely applied to lung cancer. However, the improvement
in the patient's overall survival remains dissatisfying. Previously, we demonstrated that arsenic
trioxide (As2O3) exerts an anti-lung cancer effect through anti-angiogenesis, but the details of the
mechanism in play remain unclear. Herein, we focused on the calcineurin-NFAT pathway, downstream
of VEGF, and its endogenous inhibitor DSCR1.

Objective:
To demonstrate the mechanism of As2O3 restraining lung cancer growth and metastasis by
blocking the calcineurin-NFAT pathway by upregulating DSCR1.

Methods:
We constructed xenografts and metastasis models based on wild-type (WT) and DSCR1
knockout (DSCR1-/-) mice, and carried out qPCR, Western blot, immunohistochemistry, in vivo imaging
and calculated microvessel density to evaluate the effects of As2O3 on angiogenesis, tumor growth,
metastasis, and the protein expression levels of DSCR1 and calcineurin-NFAT pathway-related molecules.

Results:
As2O3 inhibited tumor growth and metastasis, reduced microvessel formation, and induced
vascular lumen malformation in WT mice. At the protein level, As2O3 upregulated DSCR1, downregulated
NFAT2 and its downstream molecules, but had no effect on calcineurin A. However, in DSCR1-/-
mice, the above-mentioned effects of As2O3 were abolished.

Conclusion:
As2O3 can suppress lung cancer growth and metastasis through anti-angiogenesis effects
by blocking the calcineurin-NFAT pathway by upregulating DSCR1. The results shed light on the antitumor
mechanism of As2O3 and are a step forward in the identification of As2O3 as a new drug in the
treatment of lung cancer.
Advances in Stem Cell Therapy for Intestinal Diseases: Mechanisms, Perspectives
Regarding Clinical Applications, and Challenges
Authors: Fan Weiwen , Chang Le , Pan Xinghua , Zhu Xiangqing 
Published: June 2022

Background:
Intestinal disease is a common disease, which can cause serious digestion and absorption disorders, endanger the lives of patients and seriously affect the quality of life of people. Finding an effective treatment is a difficult problem at present, and stem cell therapy as a treatment has high application potential in intestinal-related diseases.

Purpose:
This paper mainly summarizes the mechanism, research progress and future development trend of stem cells in the treatment of intestinal diseases in the past decade, hoping to provide reference for future researchers in the research and application of stem cells and intestinal diseases.

Method:
Stem cells, inflammatory bowel diseases, Crohn's disease, radiation-induced intestinal injury, radiation enterocolitis, and extracellular vesicles ' were used as search terms. Relevant references in the past ten years were searched in CNKI journal full-text database, PubMed database, VIP network and Wanfang medical network, and 80 literature meeting the requirements were finally included for review.

Result:
This paper summarizes the research and application of stem cells in intestinal diseases from 2012 to 2021, and expounds the specific mechanism of stem cells in the treatment of intestinal diseases. It is found that stem cells can treat intestinal injury or inflammation through different ways. Future stem cells may also be used to reverse the natural aging of intestinal function, improve intestinal function and strengthen gastrointestinal function.
Verifying the Theory of Climate Affecting Lethality of COVID-19 by an Analysis in Two Climatic Zones of Chile
Authors: Aviles-Gonzalez Cesar Ivan , Scano Alessandra , Cossu Giulia , Littera Roberto , Campagna Marcello , Deidda Simona , Romano Ferdinando , Kalcev Goce , Firinu Davide , Meloni Federico , Carta Mauro Giovanni , Del Giacco Stefano , Restivo Angelo , Zorcolo Luigi , Marongiu Luigi , Tamburini Giorgio , Maleci Alberto , Orrù Germano , Chessa Luchino , Brasesco María Verónica 
Published: June 2022

Introduction:
The study of seasonal influences on the COVID-19 pandemic can take advantage of the unique position of Chile and its different climatic profiles in the north-south extension. The purpose is to verify the influence of seasonal climate changes on the COVID-19 in the temperate and sub-arctic areas of Chile.

Methods:
We monitored the evolution of CFR in temperate versus sub-boreal regions, reporting from the John Hopkins University COVID-19 Center on the CFR in each province in midwinter, spring, and early summer.

Results:
CFR worsened from mid-winter to mid-spring in the temperate zone of Chile, while in the sub-boreal area the CFR improves in the same period, (Kruskal Wallis Test, p=0.004). In the temperate zone after the increase in late winter-early spring, CRF tends to stabilize; on the contrary in the sub-boreal zone, there is a more marked tendency to worsen the CFR at the same time (Kruskal Wallis Test, p=0.010). The temperate zone of Chile shows a CFR increasing until spring-like temperate Europe, unlike Europe CFR does not decrease in summer, but the mean minimum temperature in temperate Chile is lower in summer than in temperate Europe. In Patagonian, CFR remains stable or drops from winter to spring but increases in early summer.

Conclusion:
The temperate and sub-boreal zones of Chile have a markedly different CFR variation profile during the COVID-19 pandemic.
PREVALENCE OF ENDOCRINE PATHOLOGY AMONG INFANTILE POPULATION IN KHARKIV REGION
Authors: Khizhnyak Oksana , Tambovtseva T. K. 
Published: June 2022

The article is devoted to investigating of main peculiarities of prevalence of endocrine pathology among infantile population in Kharkiv region. The estimation of efficiency of infantile population treatment is given according to the criteria of endocrine pathology prevalence.
Methodology For Calculating Automotive Oil Radiator
Authors: Parlyuk E. P. , Kurilenko A. V. 
Published: June 2022

The paper highlights the relevance of the problem of determining the amount of heat supplied by an internal combustion engine to a liquid cooling system when creating typical series of unified heat exchangers for tractor and combine engines (power units). A properly designed cooling system further guarantees the maintenance of the optimal thermal mode for the engine operation. A methodology for calculating the coolant characteristics of the cooling system was proposed in order to prevent possible problems related to increased parts wear, early loss of oil lubricating properties, the engine (individual units) and rubbing parts overheating, a decrease in engine power and a deterioration in the quality of the fuel-air mixture entering the cylinders.Research purpose To develop a methodology for calculating the amount of heat to be dissipated by the oil radiators of a liquid cooling system (lubrication system) being exposed to various load and engine speed modes.Materials and methods It was proposed to determine the amount of heat to be dissipated by the liquid-oil heat exchanger of the engine lube oil cooling system.Results and discussion The calculation method for oil radiators presents the calculation of the heat obtained by oil during the operation of 37-110 kilowatts automotive engines. The heat-dissipating ability of the oil surface is determined. A parameter taking into account the oil radiator heat flow is identified. The graphs of the oil surface and heat flux dependence on the engine power are presented.Conclusions The method for calculating the temperature and dynamic characteristics of the automotive engine cooling system has been developed. It makes it possible to carry out research on the radiator thermal and technical characteristics in various operating modes of machines and coolants of systems, various heat exchanger structural materials (metal, polymer), with an error of 1.5-8.0 percent.
Perseteruan Voltaire terhadap Islam dan Nabi Muhammad
Authors: Salda Maulana Iban , Rijal Syamsul , HM. Yasin Taslim 
Published: June 2022

Islam in Western thought has a very bad brand image and relative image. One western figure named Voltaire included an orientalist who insulted the Prophet Muhammad and the religion of Islam. The study aimed to find out specifically about Voltaire's understanding of the Prophet Muhammad and the religion of Islam, factors that influenced Voltaire in committing insults. The approach of the method chosen in this study is qualitative method, while the data used is sourced from literature review in the form of works written by Voltaire himself and the works of others on the work and thoughts of Voltaire. The results of the study said Voltaire initially hated Islam by mentioning the nascent religion and also called the Prophet Muhammad as a perverted many marrying women, girls and widows. Voltaire's reason for doing so was that he wanted to criticize the church's inappropriate policies through the issue of insulting Islam and the Prophet Muhammad. At the end of his history Voltaire upheld the tolerance of Islam and did not exist in Protestantism that is, Caliph Umar allowed Jews and Christians full freedom of conscience after the conquest of Jerusalem.AbstrakAgama Islam dalam pemikiran Barat mempunyai brand image dan citra relatif yang sangat buruk. Salah satu tokoh Barat yang bernama Voltaire termasuk seorang orientalis yang menghina Nabi Muhammad dan agama Islam. Penelitian ini bertujuan untuk mengetahui secara khusus tentang pemahaman Voltaire terhadap Nabi Muhammad dan agama Islam dan faktor yang mempengaruhi Voltaire dalam melakukan penghinaan. Pendekatan metode yang dipilih dalam penelitian ini adalah metode kualitatif. Adapun data yang digunakan bersumber dari telaah kepustakaan berupa karya-karya yang ditulis sendiri oleh Voltaire dan karya-karya orang lain terhadap karya dan pemikiran Voltaire. Hasil penelitian menyebutkan Voltaire pada awalnya membenci Islam dengan menyebut agama yang baru lahir dan Nabi Muhammad sebagai seorang yang mesum dan menikah dengan banyak perempuan, baik gadis maupun janda. Alasan Voltaire berpendapat demikian karena dia ingin mengkritik kebijakan-kebijakan gereja yang tidak sesuai, menurutnya melalui isu menghina Islam dan Nabi Muhammad. Pada akhir hidupnya, Voltaire menjunjung tinggi toleransi yang ada pada agama Islam dan tidak ada pada agama Protestan seperti Khalifah Umar mengizinkan kebebasan dalam pelaksanaan agamanya bagi orang beragama Yahudi dan orang beragama Kristen, hal ini terjadi setelah penaklukkan Yerusalem.
Pengaruh Tradisi Khanduri Toet Apam di Kecamatan Delima, Kabupaten Pidie
Authors: Dihanna Suci , Fajarni Suci 
Published: June 2022

Khanduri Apam is a tradition that has been practiced for generations by the community of Pidie Regency. In the ancient times, this tradition was very Islamic. Over the years, this tradition has changed. This study aims to determine the procession of the khanduri apam tradition and its influence on social, cultural, and religious values in society. The purpose of this study was to explain the Khanduri Apam tradition in the Delima community, Pidie. This study uses a qualitative method. Data collection was carried out from observations, interviews, and relevant literatures. The results showed that the Khanduri Apam had an influence on the religious life of the community in terms of Khanduri Apam considered as worship, especially when it regarded as sedekah, besides the Khanduri Apam tradition also gave a feeling of happiness to those who carried it out and who received the sedekah. For the Delima community, the Khanduri Apam tradition has been entrenched and carried out for generations by the community, and they set the month of Ra'jab as the month of practising this tradition. AbstrakKhanduri Apam merupakan salah satu tradisi yang dijalankan secara turun-temurun oleh masyarakat di Kabupaten Pidie. Pada zaman dahulu Tradisi Khanduri Apam ini sangat kental dengan Budaya Islami. Seiring perkembangan zaman tradisi ini telah mengalami perubahan dari sisi pelaksanaannya. Penelitian ini bertujuan untuk mengetahui prosesi tradisi khanduri apam dan pengaruh dari pelaksanaan tradisi tersebut terhadap kehidupan sosial, agama, dan kebudayaan masyarakat. Tujuan penelitian ini untuk mengetahui tradisi Khanduri Apam dalam masyarakat Delima, Pidie. Dalam penelitian ini, pendekatan metode yang digunakan adalah pendekatan metode kualitatif. Adapun teknik pengumpulan data dilakukan mulai dari observasi, wawancara, hingga pengumpulan dokumen yang diperlukan untuk mendukung hasil penelitian ini. Hasil penelitian menunjukkan, bahwa tradisi Khanduri Apam di Kecamatan Delima Kabupaten Pidie memberikan pengaruh terhadap kehidupan agama masyarakat, yang mana Khanduri Apam akan menjadi nilai ibadah jika diniatkan untuk bersedekah, selain itu tradisi Khanduri Apam juga berpengaruh terhadap kebahagiaan bagi mereka yang melaksanakan teot apam dan yang menerima sedekah apam, mereka yang menerima selain masyarakat umum, anak yatim, fakir maskin dan para tetangga di sekitar rumah. Bagi masyarakat Delima Tradisi Khanduri Apam sudah membudaya dan dilaksanakan secara turun-temurun oleh masyarakat, dan mereka menetapkan bulan Ra’jab sebagai bulan teot apam dan Khanduri Apam.
Pelabelan Harmonis pada Graf Sehati
Authors: Atmadja K 
Published: June 2022

Graf dapat ditulis atau dapat ditulis . Graf terdiri dari himpunan tak kosong simpul dan himpunan sisi Banyak simpul sebagai notasi Notasi sebagai banyak sisi. Pelabelan harmonis memenuhi syarat . Pelabelan Harmonis dari sebuah graf merupakan fungsi injektif dari himpunan simpul ke himpunan bilangan bulat modulo yang membangkitkan fungsi bijektif dari himpunan sisi ke himpunan bilangan bulat modulo dengan yang menghasilkan label sisi berbeda. Apabila graf dapat dilabel harmonis, maka graf termasuk Graf Harmonis. Metodologi penelitian ini diawali dengan mengambil graf harmonis, yaitu graf tangga segitiga sebagai kelas graf terhubung dan sederhana yang memuat bulatan segitiga. Penelitian dimulai pada graf yang terdiri atas bulatan segitiga yang digeneralisasi, lalu dimodifikasi seperti bentuk hati. lalu, ditambahkan tiga buah sisi sebagai penghubung untuk menghubungkannya kembali. Hasil yang didapat berupa konstruksi graf terhubung, yang berbentuk hati berderet memanjang, dan dinamakan graf sehati. Tujuan yang dicapai adalah menambah koleksi graf harmonis. Hasil akhir dari kajian penelitian ini adalah menunjukkan bahwa graf sehati merupakan graf harmonis
Pendukung Keputusan Penerima BLT-Dana Desa Menggunakan Metode Weight Product
Authors: Nacong N , Lusiyanti D 
Published: June 2022

Bantuan Langsung Tunai Dana Desa (BLT-Dana Desa) adalah program bantuan pemerintah berjenis pemberian uang tunai atau beragam bantuan lainnya. Bantuan ini diberikan untuk masyarakat miskin dengan tujuan untuk mengurangi dampak dari pandemik COVID-19. Penyaluran BLT- Dana Desa masih banyak permasalahan yang harus diselesaikan, diantaranya yaitu proses penyaluran masih terlambat, minimnya informasi terhadap penerima bantuan, penerima bantuan tidak tepat sasaran, timbulnya potensi konflik di desa, dan lain sebagainya.
Tujuan dari penelitian ini untuk merancang Pendukung Keputusan pemberian BLT-Dana Desa mengggunakan metode Weighted Product (WP). Metode WP dipilih karena mampu menyeleksi alternatif terbaik dari sejumlah alternatif dan melakukan proses perangkingan sehingga dapat mempermudah pihak pengambil keputusan dalam menentukan penerima BLT- Dana Desa. Hasil penrelitian menunjukkan bahwa alternatif ke-12 yang layak menjadi prioritas menerima BLT- Dana Desa dengan nilai vektor sebesar 0,6006
Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis
Authors: SHEN Xuan , ZHANG Yajun , JI Xuetao , LI Bo , WANG Yuzhu , Huang Yun , ZHANG Xu , YU Jingxian , ZOU Ruihan , QIN Dongdong , ZHOU Hongwen , WANG Qian , LI John Zhong 
Published: June 2022

<p>Dysregulation of hepatic very low-density lipoprotein (VLDL) secretion contributes to the pathogenesis of metabolic diseases, such as Non-alcoholic fatty liver disease (NAFLD) and hyperlipidemia. Accumulating evidence have suggested that long non-coding RNAs (lncRNAs) had malfunctioning roles in the pathogenesis of NAFLD. However, the function of lncRNAs in controlling hepatic VLDL secretion remains largely unillustrated. Here, we identified a novel long non-coding RNA, lncRHPL, which was liver-enriched, downregulated upon high fat diet feeding, and inhibited by oleic acid treatment in primary hepatocytes. With genetic manipulation in mice and primary hepatocytes, depletion of lncRHPL induces hepatic VLDL secretion accompanied with decreased hepatic lipid contents. Conversely, lncRHPL restoration reduces VLDL secretion with an increased lipid deposition in hepatocytes. Mechanistic analyses indicate that lncRHPL binds directly to heterogeneous nuclear ribonuclear protein U (hnRNPU), thereby enhances its stability, and that hnRNPU can transcriptional activate Bmal1, leading to inhibition of VLDL secretion in hepatocytes. lncRHPL deficiency accelerates the protein degradation of hnRNPU and suppresses the transcription of Bmal1, which in turn activates VLDL secretion in hepatocytes. Taken together, lncRHPL is a novel suppressor of hepatic VLDL secretion. Activating the lncRHPL/hnRNPU/Bmal1/MTTP axis represent a potential strategy for the maintenance of intrahepatic and plasma lipid homeostasis. </p>
PELAKSANAAN PEMBELAJARAN SOSIOLOGI KELAS XI IPS 1 DI SMAN 2 BATANG ANAI KABUPATEN PADANG PARIAMAN
Authors: Saravanisa Saravanisa , Nurdin Buchari , Rahayu Sri 
Published: June 2022

Penelitian ini dilatarbelakangi oleh Pembelajaran Sosiologi Kelas XI IPS 1 SMAN 2 Batang Anai dalam merencanakan dan melaksanakan pembelajaran Sosiologi pada kurikulum 2013 yang dibuat oleh guru namun belum dapat dilaksanakan sesuai dengan Rencana Pelaksanaan Pembelajaran (RPP) dan belum diterapkan di kelas. Oleh karena itu penelitian ini bertujuan untuk menganalisis perencanaan dan mendeskripsikan pelaksanaan pembelajaran sosiologi pada siswa kelas XI IPS 1 diSMAN 2 Batang Anai. Teori yang digunakan dalam penelitian ini adalah teori belajar kognitif yang dikemukakan oleh Jean Piaget. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan tipe deskriptif untuk menggambarkan masalah yang diteliti. Mengambil 7 informan. Ada dua jenis data dalam penelitian ini, yaitu data primer dan data sekunder. Pengumpulan data penelitian dilakukan dengan teknik observasi, wawancara dan studi dokumen. Analisis data dilakukan dengan mengumpulkan data, mereduksi data, menyajikan data dan menarik kesimpulan dengan unit analisis penelitian individu ini.Kata kunci: Pembelajaran, Kurikulum 2013, Sosiologi