bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-633 Poor ovarian response: what are the implications for developmental and genetic health of embryos?
Authors: Bernarde F , Piccolomini M , Duarte O , Lo Turco E , Yamakami L , Faria A , Ferreira F.P 
Published: June 2022

Abstract

Study question
Are patients with a low ovarian response more likely to develop embryos with chromosomal alterations?

Summary answer
Low ovarian response has an impact on embryonic development and the genetic normality rate of embryos.

What is known already
Low ovarian response is characterized by a reduction in the follicular response resulting in a reduced number of eggs. This fact has an impact on the outcome of assisted reproduction treatments. Therefore, understanding the genetic behavior of the embryos of these patients is still a great challenge for both the clinic and the in vitro fertilization laboratory, because, with a better understanding of the embryo's genetic segregation process, it will be possible to apply more assertive behaviors in the human reproduction routine.

Study design, size, duration
This retrospective cross-sectional study included 73 patients up to 35 years old, splitted into two groups. The poor ovarian responder group (n = 32) and the controls (n = 41). The study group included patients with poor ovarian response, less than six MII oocytes after ovarian punction. The control group was selected according to the following inclusion criteria: the presence of tubal factor unexplained infertility, or adenomyosis. The data were collected between January 2019 and December 2021.

Participants/materials, setting, methods
All patients included in the study (n = 73) underwent the same assisted reproduction treatment with embryos transferred after biopsy and PGT-A. The T-Students test was applied to compare numerical variables and the q-square test for categorical variables. All the analysis was performed in SPSS software (V26). Patients who had other factors associated with poor ovarian response were excluded.

Main results and the role of chance
In the comparison between the groups, the differences in the levels of AMH, progesterone, and the number of oocytes in MII were observed, as expected for the two groups (p &lt; 0.05). However, the control group had a higher rate of chromosomally normal embryos when compared to patients with a low ovarian response (60.9%± 30.1 vs 37.6%± 39.7, p = 0.0057) respectively. The other variables such as age, FSH, LH, BMI, estradiol, fertilization rate, rate of blastocyst formation, and quality of blastocysts did not show statistically significant differences.

Limitations, reasons for caution
Preliminary results with a low number of patients.

Wider implications of the findings
Patients with a low ovarian response may have lower rates of embryonic chromosomal normality, this fact is important for the indication of genetic testing for these couples. Future prospective studies should be carried out with a larger number of patients to understand the mechanisms that cause genetic alterations in embryos.

Trial registration number
non applicable
P-645 Intra-ovarian injection of autologous platelet-rich plasma (PRP) in poor prognosis IVF patients within 1 year of treatment: a cohort study
Authors: Barad D , Albertini D , Molinari E , Gleicher N 
Published: June 2022

Abstract

Study question
Does intraovarian injection of platelet-rich plasma (PRP) change parameters of ovarian function in patients with evidence of diminished ovarian reserve?

Summary answer
Over one year of follow-up there was no evidence of a positive effect of PRP treatment on ovarian function.

What is known already
Several authors have previously reported positive outcomes and improved response in ovarian function after treatment with PRP. However, thus far, no randomized controlled trials and few cohort studies have been published.

Study design, size, duration
This is a longitudinal cohort study following ovarian response among 80 patients with low functional ovarian reserve (LFOR) defined by AMH &lt; 1.1 ng/mL, FSH &gt; 12 mIU/mL or at least one prior IVF cycle with ≤ 3 oocytes for one year before and one year after intraovarian treatment with PRP.

Participants/materials, setting, methods
1.5 cc of PRP was injected into the cortex of ovaries in an average 12 injections per ovary. Beginning one month after their PRP treatment, patients underwent one or more cycles of ovulation induction for IVF. Outcome measures were endocrine response, and numbers of oocytes and embryos produced in by patients in response to a maximal gonadotropin stimulation before and after PRP treatment.

Main results and the role of chance
In this study women between ages 28 and 54 failed to demonstrate statistically significant outcome benefits from intra-ovarian PRP. Two very poor-prognosis 40-year-old patients with prior failed IVF cycles at other IVF centers that never reached embryo transfer, however, achieved pregnancy in an IVF cycle following PRP treatment for an ongoing pregnancy rate of 4.7% if a patient following PRP achieved retrieval of at least 1 oocyte with IVF.

Limitations, reasons for caution
This is an observational study of patients who performed poorly in past ovulation induction cycles, thus any improvement observed could have been accounted for by regression to the mean. The occurrence of two pregnancies in this group could be secondary to eventual success following a string of previous failures.

Wider implications of the findings
Even extremely poor prognosis will occasionally achieve a successful outcome from IVF. Uncontrolled case series cannot provide sufficient evidence to support routine use of an intervention like PRP. Future studies demand the use of well- controlled randomized trials.

Trial registration number
NCT04275700
P-646 IVF outcomes of embryos with abnormal PGT-A biopsy previously refused transfer – a prospective cohort study
Authors: Gleicher N , Albertini D , Molinari E , Barad D.H 
Published: June 2022

Abstract

Study question
Will patients who have embryos diagnosed as abnormal by preimplantation genetic testing for aneuploidy (PGT-A) choose to have those embryos transferred after those embryos were refused transfer at other institutions and what are the potential clinical outcomes of those transfers?

Summary answer
Many patients have selected embryos with PGT-A abnormal trophectoderm biopsies transferred since these embryos can still offer a chance of live birth.

What is known already
PGT-A is a widely practiced method of selecting embryos for transfer based on biopsy of a few cells. Many clinical practices refuse to transfer PGT-A abnormal embryos even when there are no other “normal” embryos available.

Study design, size, duration
This is a prospective cohort of 69 couples who, since 2014, moved a total of 444 PGT-A abnormal embryos previously refused transfer at their parent institutions to our practice. Among these, 50 patients have, thus far, undergone 57 transfer cycles of 141 embryos.

Participants/materials, setting, methods
Embryos diagnosed at other institutions by PGT-A as abnormal (mostly using next generation sequencing) were moved to our academically affiliated private fertility and research center in New York City. Female age at retrieval was 41.35 ± 3.98 years, 74% were Caucasian, 12% Asian and 10% were of African descent. All embryos identified as PGT-A abnormal among prospectively identified couples were recorded in our center’s registry.

Main results and the role of chance
Among the 144 embryos transferred 102 (72.3%) had only 1 or 2 chromosomal abnormalities, 30 (21.3%) had 3 or more and 9 (6.4%) were “undiagnosed” because of degraded DNA, yet still had been refused transfer. Transfer of PGT-A abnormal embryos resulted in 8 live births, 11 miscarriages and no voluntary terminations. One child was born with a segmental duplication and required repair of coarctation of the aorta as a newborn. Many couples with only PGT-A abnormal embryos are willing to have their PGT-A abnormal embryos transferred and such transfers can result in establishment of ongoing euploid pregnancies and live births.

Limitations, reasons for caution
Findings in this case series may not be representative of the wider population of couples undergoing IVF with PGT-A in general. Not all abnormal phenotypes present in the immediate postnatal period so it will be important to continue to follow the development of these children.

Wider implications of the findings
PGT-A can result in a clinics refusal to transfer embryos with abnormal PGT-A biopsies, even those with mosaic findings, consequently large numbers of infertile women are prematurely advised that their only chance of motherhood is through third-party egg-donation.

Trial registration number
Not applicable
P-674 Optimal aspiration pressure level of suction pump for oocyte retrieval in IVF-ET
Authors: Kim T.Y , Kang M.J , Han S.J , Kim S , Kim H , Ku S.Y , Suh C.S 
Published: June 2022

Abstract

Study question
What is the appropriate suction pump pressure for oocyte retrieval in terms of oocytes and embryos quality?

Summary answer
The pressure of 150mmHg had a significantly higher number of oocytes retrieved compared with 120mmHg, but the oocyte quality and embryo quality were comparable.

What is known already
There is no conclusion on the optimal aspiration pressure level for oocyte retrieval in controlled ovarian stimulation (COS), and a variety of pressures between 100 and 200 mmHg are used, often based on manufacturer’s instructions.

Study design, size, duration
A retrospective analysis was performed on a total of 211 COS cycles of infertilie patients from September 2019 to December 2021 in a single tertiary center.
110 cycles were included in the 120 mmHg pressure group and 101 cycles were included in the 150 mmHg pressure group.

Participants/materials, setting, methods
Age, AMH, antral follicle count (AFC), the proportion of ICSI, the number of retrieved oocytes, the number of MII oocytes, MII rate, degeneration rate on day 1 of culture, and the number of embryos on day 3 of culture was compared and analyzed between the two groups. Variables such as Age, AMH, and AFC that may affect the results were corrected using analysis of covariance.

Main results and the role of chance
The number of retrieved oocytes was significantly higher in the 150 mmHg group compared to the 120 mmHg group (10.3 vs. 8.4, p = 0.016). Neither the number of MII oocytes nor the MII rate was significantly different between the two groups (6.1 vs. 5.5, p = 0.509 and 67.2% vs. 73.4%, p = 0.437 respectively). The degeneration rate on day 1 of culture and the number of embryos on day 3 of culture were also not significantly different between the two groups (6.2% vs. 4.4%, p = 0.282 and 5.7% vs. 4.7%, p = 0.109 respectively).

Limitations, reasons for caution
Since this study analyzed the appropriate pump pressure for oocyte retrieval in infertile patients, caution is needed in extending the study results to patients undergoing oocyte retrieval for the purpose of fertility preservation.

Wider implications of the findings
The results of this study revealed that oocyte collection could be efficiently performed without damaging the oocytes even with a higher aspiration pressure of 150 mmHg.

Trial registration number
not applicalbe
P-769 Endometrial thickness is not associated with birthweight as well as serum levels of pregnancy-associated plasma protein-A: a retrospective analysis of 560 newborns following frozen cycles
Authors: Asoglu M.R , Bahceci M 
Published: June 2022

Abstract

Study question
Does endometrial thickness (EMT) affect birthweight and maternal serum evels of pregnancy-associated plasma protein-A (PAPP-A) in singleton pregnancies following frozen-thawed blastocyst transfer (FET)?

Summary answer
EMT does not significantly affect birthweight and maternal serum evels of PAPP-A in singleton pregnancies following FET.

What is known already
Several studies have shown an association between EMT and low birth weight in pregnancies resulting from fresh embryo transfers. Supraphyiological levels of steroid hormone during ovarian stimulation may be responsible for poor fetal growth. Few studies have investigated the relationship between EMT and fetal growth potential in frozen-thawed embryo transfers.

Study design, size, duration
This retrospective study included women who underwent first-trimester combined screening for aneuploidy after frozen-thawed blastocyst transfer and subsequently delivered a singleton live birth after 24 weeks of gestations between January 2016 and July 2020 in a private IVF center.

Participants/materials, setting, methods
A total of 560 women met the inclusion criteria and were stratified into three groups based on the EMT percentiles: &lt;7.7 mm (&lt;10th percentile), 7.7–12 mm (10-90th percentile), and &gt;12 mm (&gt;90th percentile). The primary outcome measures were mean birth weight and mean PAPP-A level. A multivariable linear regression analysis was carried out to identify the association between birth weight and EMT after adjusting for variables found at &lt; 0.1 level in the univariate analysis.

Main results and the role of chance
The mean birth weight was 3127 ± 783 g in those with EMT &lt;7.7 mm 3225 ± 644 g in those with EMT 7.7-12 mm, and 3256 ± 599 g in those with EMT &gt;12 mm (p = 0.577). The mean PAPP-A levels and PAPP-A&lt;0.5 rates were similar in the groups, as well. In multivariate analysis, the number of previous ART attempts and maternal serum levvels of PAPP-A were found to be significant predictors of birth weight (p = 0.001 and p = 0.013, respectively). EMT was not a predictor of birth weight in both univariate and multivariate analyses. The multivariate logistic regression analysis indicated that the number of previous ART attempts was an independent factor for low birth weight (OR:1.39, 95%CI:1.09-1.76, p = 0.006).

Limitations, reasons for caution
The study has inheret limitations due to its retrospective nature. Further studies are needed to investigate the relationship between EMT and birth weight along with maternal serum levels of PAPP-A.

Wider implications of the findings
Our study provided a new angle of view for evaluating the association between EMT and neonatal birth weight by analyzing this association along with maternal serum levels of PAPP-A as a marker for placental function, suggesting that EMT is not an independent factor for neonatal birth weight.

Trial registration number
NA
Resentment, status dissatisfaction, and the emotional underpinnings of Japanese security policy
Authors: Ha Thao-Nguyen , Hagström Linus 
Published: June 2022

Abstract
What explains Japan’s security policy change in recent decades? Heeding the ‘emotional turn’ in International Relations, this article applies a resentment-based framework, which defines resentment as a long-lasting form of anger and the product of status dissatisfaction. Leveraging interviews with 18 conservative Japanese lawmakers and senior officials, the article discusses the role, function, and prevalence of resentment in the remaking of Japan’s security policy, premised on constitutional revision. The analysis reveals that conservative elites are acutely status-conscious; and that those who blame a perceived inferior status on Japan’s alleged pacifism are more likely to see revision of Article 9 as an end in itself. For a subset of conservatives, however, the goal is rather to stretch the Constitution to enhance Japan’s means of deterrence vis-à-vis objects of fear or in solidarity with allies. Overall, the article demonstrates that resentment provides a fruitful lens for analyzing status dissatisfaction in international politics.
Trusting on the shoulders of open giants? Open science increases trust in science for the public and academics
Authors: Song Hyunjin , Markowitz David M , Taylor Samuel Hardman 
Published: June 2022

AbstractResearchers often focus on the benefits of adopting open science, yet questions remain whether the general public, as well as academics, value and trust studies consistent with open science compared to studies without open science. In three preregistered experiments (total N = 2,691), we find that the general public perceived open science research and researchers as more credible and trustworthy than non-open science counterparts (Studies 1 and 2). We also explored if open science practices compensated for negative perceptions of privately-funded research versus publicly-funded research (Study 2), although the evidence did not support this hypothesis. Finally, Study 3 examined how communication scholars perceive researchers and their work as a function of open science adoption, along with publication outlet (e.g., high-prestige vs. low-prestige journals). We observed open science research was perceived more favorably than non-open science research by academics. We discuss implications for the open science movement and public trust in science.
Zenker’s diverticulitis: a bitter pill to swallow
Authors: O’Neill R J , Cleere E F , Elsafty N , Gaffney R 
Published: June 2022

Abstract
Acute oesophageal obstruction from food bolus impaction is often triggered by underlying oesophageal pathology, both benign and malignant. These can be readily detected with standard investigations such as oesophagoscopy or computed tomography. Zenker’s diverticulum (ZD) is a benign condition frequently presenting with chronic dysphagia or may be asymptomatic. We report the case of an 81-year-old man with a previously undiagnosed 1-cm ZD causing complete oesophageal obstruction secondary to localized oedema from an impacted ibuprofen tablet. Although initial clinical, endoscopic and radiological findings were equivocal and suspicious for upper oesophageal malignancy, symptoms rapidly settled in response to systemic corticosteroids. The diagnosis was later confirmed on barium swallow with no other clinical, radiological or histopathological abnormalities identified. In conclusion, ZD is an uncommon cause of acute oesophageal obstruction which may occur in diverticula of all sizes. Surgery should be performed in patients with recurrent symptoms or large diverticula.
Virtual Course-Based Undergraduate Research Experience (CURE) During the COVID-19 Pandemic
Authors: Hernandez-Ruiz Eugenia , Dvorak Abbey L , Alderete Celeste 
Published: June 2022

Abstract
Translation of research to practice is essential for competent practitioners but requires skills and experience in reading and understanding research. Course-based undergraduate research experiences (CUREs) may be a means of developing research skills for all students in a course. For successful CUREs, faculty evaluate students’ research skill development and decide on a project that appropriately promotes student learning. In this case, we chose an open-ended project. We then evaluated the experiences of music students (music therapy, music performance, and music digital media) as they participated in a virtual CURE during the COVID-19 pandemic. Results of a sequential explanatory mixed-methods design with two surveys and open-ended responses of the whole group (n = 22) and a focus group with a volunteer subsample of students (n = 7) indicated important gains in understanding research articles, writing a scholarly paper, understanding the relevance of research to their coursework, and developing communication and teamwork skills. Student suggestions for improvement included clarification of the expectations and timelines, particularly in a virtual setting, and better distribution of effort during the semester. Overall, a virtual CURE may support student research skill development and help them become more effective research consumers.
Beyond Antifeminist Discourses: Analyzing How Material and Social Factors Shape Online Resistance to Feminist Politics
Authors: Holm Malin 
Published: June 2022

Abstract
Online platforms present new challenges to feminist politics since they provide antifeminist groups with additional possibilities to come together and advocate their claims towards wider publics. This article argues that new analytical perspectives are needed to understand how antifeminist discourses are successfully produced and promulgated online. In particular, it suggests that in addition to analyzing the content of antifeminist discourses we need to pay attention to how the design and governance of online platforms, as well as the resources among antifeminist activists, shape online resistance to feminist politics. Two analytical dimensions are introduced that help to specify how the design and governance of online platforms, as well as the social composition of antifeminist groups, enable these to come together online and influence mainstream publics. To demonstrate the usefulness of this analytical approach, a study of an influential antifeminist blogosphere in the Swedish context is used as an illustrative case.
The Comparative Effectiveness of Vasoactive Treatments for Hepatorenal Syndrome: A Systematic Review and Network Meta-Analysis*
Authors: Pitre Tyler , Kiflen Michel , Helmeczi Wryan , Dionne Joanna C. , Rewa Oleksa , Bagshaw Sean M. , Needham-Nethercott Natalie , Alhazzani Waleed , Zeraatkar Dena , Rochwerg Bram 
Published: June 2022

OBJECTIVE:
Hepatorenal syndrome (HRS) is associated with high rates of morbidity and mortality. Evidence examining commonly used drug treatments remains uncertain. We assessed the comparative effectiveness of inpatient treatments for HRS by performing a network meta-analysis of randomized clinical trials (RCTs).

DATA SOURCES:
We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Medline In-Process & Other Non-Indexed Citations, Scopus, and Web of Science from inception.

STUDY SELECTION AND DATA EXTRACTION:
Pairs of reviewers independently identified eligible RCTs that enrolled patients with type 1 or 2 HRS. Pairs of reviewers independently extracted data.

DATA SYNTHESIS:
We assessed risk of bias using the Cochrane tool for RCTs and certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach. Our main outcomes are all-cause mortality, HRS reversal, and serious adverse events. Of 3,079 citations, we included 26 RCTs examining 1,736 patients. Based on pooled analysis, terlipressin increases HRS reversal compared with placebo (142 reversals per 1,000 [95% CI, >87.7 to >210.9]; high certainty). Norepinephrine (112.7 reversals per 1,000 [95% CI, 52.6 to >192.3]) may increase HRS reversal compared with placebo (low certainty). The effect of midodrine+octreotide (67.8 reversals per 1,000 [95% CI, <2.8 to >177.4]; very low) on HRS reversal is uncertain. Terlipressin may reduce mortality compared with placebo (93.7 fewer deaths [95% CI, 168.7 to <12.5]; low certainty). Terlipressin probably increases the risk of serious adverse events compared with placebo (20.4 more events per 1,000 [95% CI, <5.1 to >51]; moderate certainty).

CONCLUSIONS:
Terlipressin increases HRS reversal compared with placebo. Terlipressin may reduce mortality. Until access to terlipressin improves, initial norepinephrine administration may be more appropriate than initial trial with midodrine+octreotide. Our review has the potential to inform future guideline and practice in the treatment of HRS.