bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of successful slide tracheoplasty for long-segment congenital tracheal stenosis in a neonate with a congenital diaphragmatic hernia and Fallot’s tetralogy
Authors: Todo Marie , Okuyama Hiroomi , Saka Ryuta , Tazuke Yuko , Ueno Takayoshi , Sawa Yoshiki 
Published: April 2022

Abstract
Background
Congenital tracheal stenosis (CTS) is a rare and life-threatening airway disorder, which is often associated with cardiac malformations. Among them, neonatal symptomatic CTS with cardiac malformations has an extremely poor prognosis. In contrast to cardiac malformation, congenital diaphragmatic hernia (CDH) has rarely been associated with CTS. We report a neonatal case in which slide tracheoplasty and intracardiac repair were performed simultaneously for CTS and Fallot’s tetralogy (TOF).

Case presentation
An infant with left CDH and Fallot's tetralogy (TOF) was born by cesarean section at 38 weeks of gestation. At the time of resuscitation, a 2.5 mm (ID) endotracheal tube could only be inserted just below the vocal cords. After repairing the CDH at 3 days of age, planned extubation was performed at 7 days of age. However, the patient required re-intubation due to life-threatening episodes after 2 days of the extubation. Enhanced CT revealed a long segment CTS from the upper trachea to the right bronchus (length of stenosis: 40 mm, minimum inner diameter: 2 mm). At 24 days of age, veno-arterial extracorporeal membrane oxygenation (ECMO) was introduced due to severe respiratory failure. At 28 days of age, slide tracheoplasty and palliative right ventricular outflow tract reconstruction (RVOTR) was performed with cardiopulmonary bypass (CPB). After tracheoplasty, a 3.5 mm tracheal (ID) tube could be placed in the reconstructed trachea in a patient with CTS. ECMO was completed 7 days after the operation. On the 17th day after the operation, he was extubated successfully. He was discharged 5 months after birth with home oxygenation therapy.

Conclusions
We reported the successful simultaneous correction of slide tracheoplasty and palliative RVOTR for a neonate with CDH. ECMO was used for respiratory management before and after surgery.
Calcifying fibrous tumor of the ileum resected by single-port laparoscopic surgery: a case report
Authors: Takabatake Kazuya , Arita Tomohiro , Kuriu Yoshiaki , Shimizu Hiroki , Kiuchi Jun , Takaki Wataru , Konishi Hirotaka , Yamamoto Yusuke , Morimura Ryo , Shiozaki Atsushi , Ikoma Hisashi , Kubota Takeshi , Fujiwara Hitoshi , Okamoto Kazuma , Sonobe Yuta , Tanaka Noriyuki , Konishi Eiichi , Otsuji Eigo 
Published: April 2022

Abstract
Background
Calcifying fibrous tumors (CFTs) are rare benign tumors. Because CFTs sometimes relapse, radical resection with adequate margins is necessary. We report a case of ileal CFT resected using single-port laparoscopic surgery.

Case presentation
A 33-year-old man presented with chief complaints of abdominal pain and vomiting. Computed tomography demonstrated a 45-mm-sized pelvic mass with partial calcification in the ileum. The patient was diagnosed with an ileal tumor, and partial resection of the ileum was performed using the single-port laparoscopic technique. Pathologic findings revealed hypocellular spindle cells with dense hyalinized collagen, interspersed calcification, and infiltration of lymphoplasmacytic cells. Immunohistochemical analysis showed that the factor XIIIa was positive and other tumor-specific markers were negative. Based on these findings, the tumor was finally diagnosed as a CFT.

Conclusions
Although CFT is benign, multifocal and recurrent CFTs have been reported. Therefore, careful intraperitoneal observation and curative resection are necessary. Single-port laparoscopic surgery is acceptable, both in terms of curability and minimal invasiveness.
Traditional medicinal plants used by hypertensive patients in Belize: a qualitative evaluation of beliefs and practices
Authors: Mphuthi David D. , Husaini Danladi Chiroma 
Published: April 2022

Abstract
Background
Belize is rich in rainforest and vast medicinal plants that have the potential for drug discoveries. Few studies have examined the use of medicinal plants in the management of chronic diseases in Belize. The present study appraised indigenous Belizeans' opinions, beliefs, and practices of medicinal plants used for hypertension management. Twenty-four hypertensive patients were interviewed using a semi-structured interview guide from January to May 2019. Interview results were transcribed using Microsoft Excel and loaded into qualitative data analysis (QDA) Miner Lite version 2.0.6 online software for coding. The integrated themes and sub-themes generated were presented in narrative passages and used to summarize study findings on medicinal plants used in the management of hypertension in Belize.

Results
Fifteen medicinal plants belonging to 15 plant families were reported by the participants as medicinal plants used to manage hypertension. The plants include Annona muricata, Artocarpus altilis, Cecropia peltata, Ananas comosus, Cymbopogon andropogoneae, Uncaria tomentosa, Allium sativum, Bixa orellana, Moringa oleifera, Momordica charantia, and Cassia grandis. Leaves were the most commonly used plant part; decoction was the most common method of preparation, while ½ to 1 glass was the daily recommended dose. Mild side effects were reported, while antioxidant activity was the perceived efficacy.

Conclusion
Hypertensive patients in Belize opined that medicinal plants and herbs were efficacious in lowering blood pressure, as evidenced by home monitoring and regular checkups at the hospital. They also reported minimal side effects in the use of the medicinal plants. There is a need for a comprehensive evaluation of Belize’s medicinal plants to unravel their potential for drug discovery.
Role of ultrasound and colored Doppler examination in the diagnosis and the classification of the superficial soft tissue vascular anomalies
Authors: Habib Asmaa Hussein Ibrahim , El-Kaffas Khalid Helmy , Mustafa Ahmed Sayed , Mashour Shady Nabil 
Published: April 2022

Abstract
Background
Vascular anomalies are congenital lesions of abnormal vascular development, and a primary distinction have to be made between a vascular tumor and a vascular malformation, hemangiomas are considered the commonest vascular tumor, correct diagnosis is imperative for appropriate treatment. In this report, we tried to verify the role of ultrasonography and Doppler examination in the initial diagnosis, the classification of vascular anomalies and in the post-treatment follow-up.

Results (main findings)
This report included cases of vascular anomalies who attended the interventional radiology department as well as the vascular anomaly clinic in Abo El-Rish hospitals during the period 2019 through 2021. Data of all patients attending the clinic were prospectively examined. Files of 60 cases with vascular anomalies were available for review. The diagnosis of vascular anomalies was done according to their history and characteristic findings at clinical examination as well as U/S and color Doppler examinations, MRI and angiographic studies were done as needed. A significant female predominance was noticed. A significant predominance in the head and neck region was noticed (60%). Treatment was individualized according to each case; propranolol was chosen as the first line of treatment in IH. Intra-lesional steroids injections were done in hemangiomas, and intra-lesional bleomycin was done in venous and lymphatic malformations, endovascular embolization was done in high flow vascular malformations.

Conclusion
Ultrasound and color Doppler examination were effective and accurate methods in the diagnosis, the classification of superficial soft tissue vascular anomalies, the detection of early complications and in the follow-up after different treatment methods applied, it was also beneficial in the exclusion of non-vascular lesions.
Experimental Schistosoma japonicum-induced pulmonary hypertension
Authors: Kassa Biruk , Lee Michael H. , Kumar Rahul , Mickael Claudia , Sanders Linda , Tuder Rubin M. , Mentink-Kane Margaret , Graham Brian B. 
Published: April 2022

BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species,Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependentS.mansonipulmonary hypertension (PH). We sought to determine if another common species,S.japonicum, can also cause experimental PH.MethodsSchistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis.ResultsS.japonicumsensitized and challenged mice developed PH, which was milder than that followingS.mansonisensitization and challenge. The degree of pulmonary vascular remodeling and Type 2 inflammation in the lungs was similarly proportionate. Cross-sensitization revealed that antigens from either species are sufficient to sensitize for intravenous challenge with either egg, and the degree of PH severity depended on primarily the species used for intravenous challenge. Compared to a relatively uniform distribution ofS.mansonieggs,S.japonicumeggs were observed in clusters in the lungs.ConclusionsS.japonicumcan induce experimental PH, which is milder than that resulting from comparableS.mansoniexposure. This difference may result from the distribution of eggs in the lungs, and is independent of which species is used for sensitization. This result is consistent with the clearer association betweenS.mansoniinfection and the development of schistosomiasis-associated PAH in humans.
Deep learning time series prediction models in surveillance data of hepatitis incidence in China
Authors: Xia Zhaohui , Qin Lei , Ning Zhen , Zhang Xingyu 
Published: April 2022

BackgroundPrecise incidence prediction of Hepatitis infectious disease is critical for early prevention and better government strategic planning. In this paper, we presented different prediction models using deep learning methods based on the monthly incidence of Hepatitis through a national public health surveillance system in China mainland.MethodsWe assessed and compared the performance of three deep learning methods, namely, Long Short-Term Memory (LSTM) prediction model, Recurrent Neural Network (RNN) prediction model, and Back Propagation Neural Network (BPNN) prediction model. The data collected from 2005 to 2018 were used for the training and prediction model, while the data are split via 5-Fold cross-validation. The performance was evaluated based on three metrics: mean square error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE).ResultsAmong the year 2005–2018, 20,924,951 cases and 11,892 deaths were supervised in the system. Hepatitis B (HB) is the most disease-causing incidence and death, and the proportion is greater than 70 percent, while the percentage of the incidence and deaths is decreased much in 2018 compared with 2005. Based on the measured errors and the visualization of the three neural networks, there is no one model predicting the incidence cases that can be completely superior to other models. When predicting the number of incidence cases for HB, the performance ranking of the three models from high to low is LSTM, BPNN, RNN, while it is LSTM, RNN, BPNN for Hepatitis C (HC). while the MAE, MSE and MAPE of the LSTM model for HB, HC are 3.84*10−06, 3.08*10−11, 4.981, 8.84*10−06, 1.98*10−12,5.8519, respectively.ConclusionsThe deep learning time series predictive models show their significance to forecast the Hepatitis incidence and have the potential to assist the decision-makers in making efficient decisions for the early detection of the disease incidents, which would significantly promote Hepatitis disease control and management.
Polygonum subaphyllum Sumnev. – a new species in the flora of Russia
Authors: Tupitsyna Natalya N. 
Published: April 2022

Polygonum subaphyllum is reported here as a new species for the flora of Russia based on collections from several Siberian regions (Novosibirsk Region, Altai Territory, Trans-Baikal Territory and Republic of Sakha (Yakutia)) revealed among the materials of NS and KRAS. In Siberia, Polygonum subaphyllum grows in solonetzic steppes, on sands, on agricultural fields and along the roads. It belongs to Polygonum sect. Polygonum subsect. Patula (Polygonaceae). The key for identification of Siberian species of subsection Patula (P. subaphyllum, P. novoascanicum and P. patulum) is given.
Fracture behavior of multiple adhesive postinstalled anchors subjected to shear force
Authors: Tajima Yuji , Hoki Kazuaki 
Published: April 2022

In this study, experiments were conducted on post-installed anchors subjected to shear force in order to enhance applicability when post-installed anchors were used for seismic reinforcement. Furthermore, since there were a large number of post-installed anchors when they were actually used, an experiment was conducted in which aăshear force was simultaneously applied to one to four anchors. In this study, it was focused on number and pitch of anchors. Major findings of this study were summarized as follows: in case of 22.46 (N/mm2) for concrete compressive strength, shear strength of anchors was not double, triple, and quadruple as number of those increased to 2, 3, and 4, and that gradually decreased as number of those increased, the boundary condition between anchor shear rupture and pry-out failure was found that concrete compressive strength was 25.12 (N/mm2) or less and anchor pitch was 30 to 50 mm, and anchor was tensile strength over SD390.
Tension-free thyroidectomy — results of the initial 77 operations
Authors: Sleptsov I. V. , Chernikov R. A. , Sablin I. V. , Pushkaruk A. A. , Timofeeva N. I. 
Published: April 2022

BACKGROUND: Surgeons from all over the world make considerable efforts to reduce thyroid intraoperative complications such as recurrent laryngeal nerves trauma and parathyroid vascular supply damage.AIM: The aim of the study was improving thyroidectomy technique to reduce the rate of postoperative complications.MATERIALS AND METHODS: Inclusion criteria were primary thyroid operation in cases of papillary or medullary cancer, follicular tumours (Bethesda IV) and Grave’s disease. Thyroid volume ranged from 12–70 ml. Tension-free technique of thyroidectomy (TFT) was suggested by the authors of this study. Key points of TFT are the following: the first step is the complete dissection of Berry ligament fibers and terminal branches of lower thyroid arteries and vein. There is only lateral traction while medial traction is not applied at all. Mobilization of the upper parathyroid gland is performed at the medial thyroid surface. Thyroid lobe is extracted out of its bed beginning with the lower pole only after complete dissection of Berry’s ligament, vessels and parathyroid glands. The last step of the operation is the dissection of the upper pole thyroid vessels. The mobilized lobe is easily withdrawn downwards, that leads to space increase between external branch of the superior laryngeal nerve and the upper pole of the lobe. Transient and continuous neuromonitoring as well as optical magnification and headlamps were used during operations. Vocal cords function was controlled before and after surgery (on the first day) by means of ultrasound or endoscopic laryngoscopy. Ionized calcium and parathyroid hormone levels were checked in cases of total thyroidectomy group on the day of surgery, on the 1st and 14th postoperative days.RESULTS: 77 consecutive patients were included into the study (continuous sampling of patients). 33 hemithyroidectomies, 13 hemithyroidectomies with central ipsilateral neck dissection, 21 thyroidectomies, 8 thyroidectomies with central neck dissection, 2 thyroidectomies with central and lateral neck dissection were performed by the same surgeon. All the operations were performed by tension-free technique (TFT). There were no cases of loss of signal from the recurrent laryngeal nerves function during all the operations. One case of postoperative transient hypoparathyroidism finished with normalization of parathyroid hormone and calcium levels in 2 weeks after the operation.CONCLUSION: initial experience in TFT allows to recommend this procedure for further practicing and examination.
Features of preparation and surgical aspects of treatment of patients with ACTH-producing neuroendocrine lung tumors
Authors: Pikunov M. Yu. , Pechetov A. A. , Golounina O. O. , Buryakina S. A. , Rozhinskaya L. Ya. , Belaya Zh. E. 
Published: April 2022

BACKGROUND: The Department of Thoracic Surgery of the National Medical Research Center of Surgery named after A. V. Vishnevsky has been dealing with the problem of surgical treatment of patients with neuroendocrine lung tumors for more than 20 years. This article presents the experience of treating patients with ectopic ACTH syndrome over the past 15 years.AIM: To study the features of preparation, surgical aspects of treatment and delayed results in patients with ACTH-producing tumors of bronchopulmonary localization.MATERIALS AND METHODS: The study included 55 patients who underwent surgical treatment of ACTH-producing neuroendocrine tumor of bronchopulmonary localization in the period from 2005 to 2020. In order to systematize the approach to surgical treatment and the choice of the type of operation, a point analysis of the patient’s severity has been developed. Demographic information about patients, anamnesis data, results of hormonal and instrumental studies at pre- and postoperative stages and long-term treatment results were analyzed. The control period of observation of patients after surgery ranged from 6 months to 5 years.RESULTS: The age of the patients ranged from 18 to 72 years (36±15). According to the MSCT results of the chest, neoplasms in the lungs ranging in size from 5 to 25 mm were detected. Patients who scored from 18 to 23 points had lung resection due to the severity of the condition. With a total score from 14 to 18, segmentectomy with lymph node dissection was performed. When the total score was less than 14, a lobectomy with lymph node dissection was performed. During the planned histological examination, lung neuroendocrine tumor of various differentiation degree was confirmed in all patients. The results of treatment were followed in the period from 6 to 60 months, with a median of 19 months [10;24]. Regression of clinical manifestations of hypercortisolism after 1 year of dynamic follow-up period was detected in 83% of patients. After 60 months of follow-up 10 patients (71.4%) had a persistent clinical effect after surgical treatment with complete regression of hypercortisolism symptoms.CONCLUSION: The analysis of the results of surgical treatment, according to the proposed methodological aspects, with dynamic control after 6, 12 and 36 months showed the effectiveness of such surgical intervention with results comparable to the world indicators of leading clinics.
Diffusion of molecules through nanopores under confinement: Time-scale bridging and crowding effects via Markov state model
Authors: Bodrenko Igor V. , Milenkovic Stefan , Ceccarelli Matteo 
Published: April 2022

Abstract
Passive transport of molecules through nanopores is characterized by the interaction of molecules with pore internal walls and by a general crowding effect due to the constricted size of the nanopore itself, which limits the presence of molecules in its interior. The molecule–pore interaction is treated within the diffusion approximation by introducing the potential of mean force and the local diffusion coefficient for a correct statistical description. The crowding effect can be handled within the Markov state model approximation. By combining the two methods, one can deal with complex free energy surfaces taking into account crowding effects. We recapitulate the equations bridging the two models to calculate passive currents assuming a limited occupancy of the nanopore in a wide range of molecular concentrations. Several simple models are analyzed to clarify the consequences of the model. Eventually, a biologically relevant case of transport of an antibiotic molecule through a bacterial porin is used to draw conclusions (i) on the effects of crowding on transport of small molecules through biological channels, and (ii) to demonstrate its importance for modelling of cellular transport.
Experimental investigation of composite steel–concrete beams using symmetrical and asymmetrical castellated beams
Authors: Al-Thabhawee Hayder Wafi 
Published: April 2022

Abstract
This study aims to investigate the behavior of concrete slabs acting compositely with symmetrical and asymmetrical castellated beams. Stud connectors are used to connect the concrete slab and steel section. The use of castellated steel beams to build up composite steel-concrete beams is now common practice in building construction. Five simply supported composite beams were examined under two-point loading. Two specimens built up from standard steel beams were used as control specimens and three specimens were built up from castellated steel beams. One of these specimens was built up using a castellated steel beam with an asymmetrical cross-section fabricated from two different standard sections (IPE120/HEA120). The concrete slab of all composite specimens had the same dimensions and properties. The experimental results showed that strength and rigidity were considerably greater for composite castellated steel beams compared to composite beams built up from the parent sections. The ultimate load capacity of a composite castellated beam fabricated from an IPE120 section was 46% greater than that of a composite beam built up using the parent beam, and the ultimate load capacity of a composite castellated beam fabricated from a wide-flanged HEA120 section resulted in an increase of 21% over the parent beam control specimen. The ultimate load capacity of the composite specimen built up using the asymmetrical castellated beam (IPE120/HEA120) achieved increases of 69% and 12%, respectively, compared to the control specimens built up from standard sections.
Experimental investigation and thermodynamic assessment of the Al–Ca–Y ternary system
Authors: Zhang Ligang , Song Qian , Jiang Yurong , Zhao Fenyan , Liu Libin 
Published: April 2022

Abstract
The experimental investigation and thermodynamic assessment of the Al–Ca–Y ternary system were carried out in this work. The isothermal section of the Al–Ca–Y ternary system at 673 K and 873 K was determined by using equilibrated alloys, combined with scanning electron microscopy, electron probe micro-analysis and powder X-ray diffractometry. Phase transition temperatures were measured by differential scanning calorimetry analysis. A certain range of solubility was detected between Al2Ca and Al2Y in this work, the maximum solid solubility of Y in Al2Ca was 11.9 at.% and that of Ca in Al2Y was 12.6 at.%. According to the thermodynamic data of binary systems in the literature and the ternary experimental data from this work and the literature, the Al–Ca–Y ternary system was optimized and a set of self-consistent thermodynamic parameters was obtained. Calculated phase equilibria were consistent with the experimental results.