bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertebral anomalies associated with anorectal malformations incidentally found on contrast studies: a case series
Authors: Nike Felicia , Anandasari Pande Putu Yuli 
Published: December 2022

Background: Spinal congenital malformations are closely associated with other congenital anomalies, are usually asymptomatic and be found incidentally. Moreover, spine abnormalities such as hemivertebra may cause further complications if left untreated. Among patients with VACTERL anomalies, spine anomalies account for 60-95% of them. This report aimed to describe rare and interesting cases of spinal malformation in children to provide further information on the importance of a proper approach in such cases.
Case Presentation: We present three pediatric cases of vertebral anomalies associated with anorectal malformations incidentally found in contrast studies. All patients have a history of anorectal abnormalities at birth and are referred to the hospital for contrast studies. The first case found semi-segmented hemivertebra at T8-9 levels, cleft at T10 level and high-type anorectal malformations (ARMs). The second case showed unsegmented hemivertebra at the level of L1 and butterfly vertebra at T10, approximately at the same level as the skin lesion, with the possibility of occult spina bifida and high-type ARMs. The third case revealed bilateral vesicoureteral reflux (VUR), grade 1 right hydroureteronephrosis and left hydroureter, with semi-segmented hemivertebra at the level of L3, unsegmented hemivertebra at L4-5 and an extra lumbar vertebra, possibly a lumbosacral transitional vertebra (LSTV).
Conclusion: Thorough screening and other examinations such as contrast studies could reduce their morbidity as more sophisticated imaging may be done to better visualize the anatomical malformation.
Visual science mapping and future direction of pediatric acupuncture: a bibliometric analysis from Scopus database and VOSviewer
Authors: Handayani Selfi , Wiyono Nanang , Kartikasari M. Nur Dewi , Suparyanti Endang Listyaningsih , Moelyo Annang Giri , Balgis  , Muhammad Faizal , Iman Ahmad Fasichul 
Published: December 2022

Introduction: Pediatric acupuncture is an interesting subject to study along with strengthening the current development of acupuncture therapy. Not only for adults, but acupuncture is also safe for children. There have been many studies on acupuncture, but publications related to acupuncture for children are still very few compared to adults. The purpose of this study is to visually map and guide future research on Pediatric acupuncture based on bibliometric analysis.
Method: We conducted this study from September 16 to 19, 2022. Publications regarding pediatric acupuncture were extracted from the Scopus database. The search strategy included two keywords: (ACUPUNCTURE)*(PEDIATRIC). The final result was acquired by searching those keywords without limitation because the number of articles was less than 1000. We used VOSviewer and bibliometric indicators to generate a maps-based data network from all keywords-related studies showing association among journals, countries, publication frequency, authors, and citations. Keywords were used to infer pediatric acupuncture. A total of 669 documents related to pediatric acupuncture were retrieved. This includes 432 articles, 176 reviews, and 16 conference papers.
Results: A total of 10,918 citations have been recorded for all publications with an h-index count of 52. The first relevant study is dated on 1966. Since then, there has been a steady increase in total publications each year whereas 2021 as the most productive year with 53 publications. The Medical Acupuncture Journal (25) was the most prolific journal. The United States of America (298) and China (54) are the most productive country and institutions. The article entitled Clinical Practice Guideline: Allergic rhinitis by Seidman et al. (386) is the most cited reference.
Conclusion: The benefit and potential of acupuncture for several diseases in pediatric patients are promising and no adverse side effects have been reported.
Excessive physical exercise caused a decrease in CD4+ and Hematopoietic Stem Cell (HSC) levels in Wistar rats
Authors: Putrawan Si Ngurah Oka , Jawi I Made , Yasa I Wayan Putu Sutirta , Subawa Anak Agung Ngurah , Manuaba Ida Bagus Putra 
Published: December 2022

Background: Excessive physical exercise can cause injury and disrupt the body's homeostasis. Excessive physical exercise also causes increasing oxygen demand and reactive oxygen species production (ROS) that induce damage in various cells and body tissue, including HSC and CD4+ cells. This study aims to prove that excessive physical exercise decreases the CD4+ and HSC levels in Wistar rats and evaluates the correlation between HSC and CD4+ cell levels.
Methods: An experimental study with a randomized post-test-only control group design was conducted among 44 male Wistar rats in Clinical Pathology Laboratory, Mangusada General Hospital, Bali, from June to September 2022. The samples were divided into two groups; 22 rats received excessive physical exercise (treatment group) and 22 rats as the control group. The CD4+ cells and HSC were examined after 14 days of intervention. Data regarding the means of CD4+ and HSC levels between the two groups were assessed, and the correlation between HSC and CD4+ cell levels was analyzed using SPSS version 21 for Windows.
Results: We used 22 rats for each treatment and control group. The mean level of CD4+ and HSC were significantly lower in the treatment group compared to the control group (356.41 vs. 661.41x106 cell/µl; p<0.001) and (359.14 vs. 551.09 x106 cell/µl). We found a statistically significant difference in CD4+ and HSC levels between the two groups, p<0.001). We also found a positive correlation between HSC and CD4+ level with r=0.636; p<0.001. Excessive physical exercise affected the immune function by decreasing CD4+ ad HSC levels in Wistar rats.
Conclusions: The impact of excessive physical exercise on immune function showed by decreasing the level of CD4+ and HSC level in Wistar rats. The HSC number also has a positive correlation with CD4+ cell level.
Association between insulin, glucagon, high sensitive c-reactive protein, insulin resistance with visceral adipose tissue-derived serine protease inhibitor (VASPIN) in obese population
Authors: I Made Pande Dwipayana  , Wira Gotera  , Ketut Suastika  , I Wayan Putu Sutirta Yasa  , Anak Agung Gede Budhiarta  , Made Ratna Saraswati  , I Made Siswadi Semadi  , Ida Bagus Aditya Nugraha  
Published: December 2022

Background: Obesity is an inflammatory condition that results in an increase in high sensitive C-Reactive Protein (hs-CRP), a risk for insulin resistance (IR). Vaspin has the effect of increasing insulin receptor sensitivity and on the other hand is a compensatory response to insulin resistance, one of which is measured by homeostasis models assessment-insulin resistance (HOMA-IR). This study was an analytical cross-sectional observational design, to determine the association between insulin, glucagon, CRP, and HOMA-IR levels with serum vaspin in obesity.
Method: This study is an analytical study with a cross-sectional design. Criteria of inclusion were subjects in the range 18-60 years Denpasar citizen with BMI above 25 kg/m2 and willing to be involved in this study, while exclusion criteria were with either chronic conditions or acute inflammation such as infection, cancer, tumor, or chronic disease which is altered and threatening life. Correlation tests using spearman analysis.
Results: From 131 obese subjects in this study, there were 72 (55%) men and 59 (45%) women. Median age: 33 (22-57) years, fasting insulin: 8.90 (2.20-74.50) ìIU/mL, glucagon: 48.10 (7.58-293.90) pq/mL, hs-CRP: 1.90 (0.20-9.50) mg/L, HOMA-IR: 2 (0.50-23.15), and vaspin levels: 0.16 (0.04-1.46) ng/mL. There was a significant positive correlation between HOMA-IR, insulin and glucagon with vaspin (r = 0.20, p = 0.020; r = 0.20, p = 0.022; and r = 0.28, p = 0.001), and a significant negative correlation between hs-CRP and vaspin (r = -0.24, p = 0.005) in obesity. In the path analysis, there was a direct and total negative effect of hs-CRP on vaspin (coefficient = -0.19; p = 0.027 and coefficient = -0.02; p = 0.038).
Conclusion: This study shows a positive association between insulin, glucagon, and HOMA-IR with serum vaspin, while CRP is negatively associated with serum vaspin in obesity.
IODINE LEVEL OF IODIZED SALT REQUIRED IN ENDEMIC AREA
Authors: Gunung I Komang 
Published: December 2022

Iodized salt had been used in many countries for long term iodine deficiency disorders (IDD) control program. Several things should be considered related to iodine loss in iodized salt, e.g. iodine loss during cooking that may effect the effectivity of the program. Too high iodine level on the other hand, will cause health problems such as iodine-induced hyperthyroidism (IIH) and autoimmune thyroiditis. The purpose of this study was to know the level of iodine in iodized salt required in endemic area to meet the iodine recommended daily allowance (RDA) of 150 ?g/person/day. This study was a field trials using treatment by subyect design. Ten schoolchildren were selected systematically to get ten clusters of schoolchildren families. All members of the families were 33 persons (2 families were droped out). Urine examination showed the mean of urine iodine excretion (UIE) 84.8 Â± 32.11 ?g/L and 208.1 Â± 89.24 ?g/L of non-iodized salt and iodized salt consumption respectively. Salt intake was 6.64 g/person/day and iodine loss during cooking was 25%. Iodine level of iodized salt required in mild endemic area was 22 ppm at consumer level or 32 ppm at production level. This result wasÂ slightly higher than the minimum range (30 ppm) and much lower than the maximum range (80 ppm) was the level of iodine in iodized salt that was detemined by the government (30-80 ppm). Based on this finding, the range of iodine level in iodized salt production should be rivised according to the endemicity of area (mild, moderate, and severe).
THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
Authors: Budhitresna AAG , Suastika Ketut , Mantik Astawa Nyoman , Santoso Anwar 
Published: December 2022

Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-Î± , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the Î²-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WCÂ â‰¥ 90cm; female WCÂ â‰¥ 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-Î± and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 Â±16,84 Âµg/ml) statistically higher than that without type 2 DM group (41,13 Â±14,75 Âµg/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 â€“ 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob.Â It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.
ERGONOMICS-JOB STRESS INTERVENSION (ERGO-JSI) REDUCES STRESS OF EMPLOYEES AT NATIONAL BANK IN DENPASAR
Authors: Purnawati Susi , Pangkahila Alex , Raka Sudewi Anak Agung , Sutjana D. P. 
Published: December 2022

Â Work stress may affect the quality of working life due to decrease of work ability, cognitive ability, and may also lead to risky behavior. The decrease in work stress could be reflected by the decrease in stressor, psychological distress and cortisol levels among employees. An ergonomic job stress intervention (Ergo-JSI) applied in this study has several advantages in regard to participatory ergonomics and individual orientation. The objective of this research is to analyze the decrease in job stress reflected by the decrease in stressor, psychological distress and cortisol levels among the employees of a National Bank in Denpasar, Bali, after the application of Ergo-JSI.This is an experimental study with treatment by subject design which was conducted from January to September 2011. Several dependent variables such as stressor and psychological distress were measured using the Indonesian version of Brief Job Stress Questionnaire (BJSQ), while the blood cortisol was measured using chemiluminescence technique. Totally 25 male employees of the Private National Bank in Denpasar 25 were used as the research subjects. They were randomly selected and their ages averaged 39.After the application of Ergo-JSI, a significant change (p < 0.05), that is, a 6.8% decrease in stressor and a 23.7% fall in cortisol were found. Apart from that, a significant change (p< 0.05), that is, a 28% decrease in psychological distress was also found.It could be concluded that the application of Ergo-JSI reduces job stress among the employees of the National Bank in Denpasar, Bali.
HEADACHE--A SINONASAL SYMPTOM AND MOREâ€¦ A REVIEW ARTICLE
Authors: Kaur A , Singh A 
Published: December 2022

Headaches and facial pain are common complaints.Â In many cases, patients are referred to an otolaryngologist to determine if head pain is sinus related.Â In the absence of other nasal or sinus symptoms, some rhinogenic headaches can be overlooked or misdiagnosed.Â A complete history and thorough ENT examination, including nasal endoscopy with or without coronal CT scans is key to the correct diagnosis.1Â Headache resulting from disease of the nose or paranasal sinuses are usually associated with symptoms (congestion, fullness, discharge, obstruction) that point to the site of origin.Â Occasionally, however nasal or sinus disease can be manifested solely as headache.
Deteksi gen Gtf-B Streptococcus mutans dalam plak dengan gigi karies pada siswa di SD N 29 Dangin Puri
Authors: Ambarawati I Gusti Agung Dyah , Sukrama I Dewa Made , Yasa I Wayan Putu Sutirta 
Published: December 2022

Background: Bacteria situated in the formation of dental plaque as a leading cause of caries is Streptococcus mutans. Streptococcus mutans use glycosyltransferase enzymes to convert saccharose saliva into an extracellular polysaccharide (PSE) through glycosylation process. One of the virulence factors of Streptococcus mutans is the gtf-B gene.Aim: This study aims to detect gtf-B gene in plaque with dental caries on students of SD Negeri 29 Dangin Puri.Method: The design of the study was descriptive observational research involved 51 carries children as a sample in SD Negeri 29, Dangin Puri. Bacterial culture was applied to detect colonies of Streptococcus. Additional gram staining and catalase test were also conducted to distinguish Streptococcus against Staphylococcus. After it revealed negative catalase test, PCR was continued optimally about 517 bp in size and 585 bp gtf B gene in size.Result and Conclusion: Streptococcus mutans are as many as 19 samples from 51 samples (37.25%). Three samples from 19 isolates of Streptococcus mutans were detected by gtf-B gen (16%). Bakteri yang berperan penting dalam pembentukan plak gigi sebagai penyebab karies adalah Streptococcus mutans. Streptococcus mutans memiliki enzim glikosiltransferase yang dapat mengubah sakarosa saliva menjadi polisakarida ekstraseluler (PSE) melalui proses glikosilasis. Salah satu faktor virulensi bakteri Streptococcus mutans sebagai penyebab karies gigi adalah gengtf-B Streptococcus mutans. Tujuan: Penelitian ini bertujuan untuk mendeteksi gen gtf-B Streptococcus mutans dalam plak dengan gigi karies pada anak di SD Negeri 29 Dangin Puri.Metode: Penelitian ini menggunakan 51 sampel anak di SD Negeri 29 Dangin Puri yang mengalami karies. Kultur bakteri digunakan untuk mendeteksi koloni Streptococcus Sp. kemudian dilakukan pengecatan gram, uji katalase untuk membedakan Streptococcus dengan Staphylococcus. Hasil uji katalase negatif dilakukan proses PCR Streptococcus Mutans dengan ukuran 517 bp dan gen gtf B Streptococcus mutans dengan ukuran 585 bp.Hasil dan Simpulan: ditemukan bakteri streptococcus mutans sebanyak 19 sampel dari 51 sampel (37,25%). Tiga sampel dari 19 isolat bakteri streptococcus mutans terdeteksi gen gtfB streptococcus mutans (16%).
Hubungan antara peningkatan kadar immunoglobulin-e (IgE) dengan matrix metalloproteinase-9 (MMP-9) pada pasien sindrom koroner akut (SKA) di RSUP Sanglah, Denpasar, Bali
Authors: Prabundari Anak Agung Yunda , Suardamana Ketut , Suryana Ketut , Saturti Tjok Istri Anom 
Published: December 2022

Introduction. Acute Coronary Syndrome (ACS) is a cardiovascular disease that has a high mortality rate. One of the markers which play a role in the pathophysiology of ACS is Immunoglobulin E (Ig E), one of the antibodies released by B lymphocytes as the result of complex interactions that can activate mast cells. Mast cells will activate Metalloproteinase-9 (MMP-9) then facilitate pathogenesis of acute myocardial infarction or acute coronary syndrome phase. This study aimed to determine the relationship between increasing levels of IgE and MMP-9 in ACS patients at Sanglah Hospital, Denpasar, Bali.Method. This was a cross-sectional analytic study, and the samples were collected from ACS patients at Sanglah Hospital, Denpasar, Bali, using a consecutive sampling method. A total of 73 samples were included in this study, then statistical tests and Pearson correlation test was conducted.Results. Seventy-three samples included in this study contain 59 men (80.8%) and 14 women (19.2%). The IgE level is between 0.5-1000 and MMP-9 levels between 6.91-29.56. There is a statistically significant correlation between IgE levels and MMP-9 levels in Acute Coronary Syndrome patients (p = 0.018: r = 0.277).Conclusion. We found a significant association between increased IgE and MMP-9 in patients with Acute Coronary Syndrome at RSUP Sanglah, Denpasar, Bali. Pendahuluan. Sindrom Koroner Akut (SKA) merupakan penyakit kardiovaskular dengan angka kematian yang sangat tinggi. Salah satu marker yang berperan dalam patofisiologi SKA adalah Immunoglobulin E (IgE). IgE merupakan salah satu antibodi yang dilepaskan oleh limfosit B sebagai interaksi kompleks yang dapat mengaktivasi sel mast. Sel mast yang sudah aktif akan mengaktivasi Metallopriteinase-9 (MMP-9) yang ikut berperan dalam patogenesis miokard infark akut atau sindrom koroner akut. Penelitian ini bertujuan unuk mengetahui hubungan peningkatan kadar IgE dan MMP-9 pasien SKA di RSUP Sanglah, Denpasar, Bali.Metode. Penelitian ini merupakan penelitian potong lintang analitik yang dilakukan pada populasi SKA di RSUP Sanglah, Denpasar, Bali. Sampel keseluruhan berjumlah 73 orang pasien SKA secara konsekutif diikutsertakan dalam penelitian ini, kemudian dilakukan uji statistik dan uji korelasi Pearson.Hasil. Dari hasil penelitian pada 73 sampel tersebut, didapatkan jumlah sampel 59 orang laki-laki (80,8%) dan 14 orang perempuan (19,2%). Adapun kadar IgE dalam rentang antara 0,5-1000 dan kadar MMP-9 antara 6,91-29,56. Terdapat korelasi yang bermakna antara kadar IgE dengan kadar MMP-9 pada pasien Sindrom Koroner Akut (p=0,018; r=0,277).Kesimpulan. Terdapat hubungan yang signifikan antara peningkatan kadar IgE dengan peningkatan kadar MMP-9 pada pasien Sindrom Koroner Akut di RSUP Sanglah, Denpasar, Bali.
Faktor yang berhubungan dengan perilaku tes HIV pada ibu hamil di Puskesmas Abiansemal I
Authors: Purwani Ni Luh Putu Suci Hary , Yuliana Yuliana , Wardana I Nyoman Gede 
Published: December 2022

Background: HIV transmission vertically within children or infants become essential point of view for reducing HIV cases. Aim: The study aims to find out the related factors of HIV test behavior among pregnant women in public primary healthcare Abiansemal I.Method: This study used analytical cross-sectional design and consecutive sampling among pregnant women who have routine examination in public primary healthcare Abiansemal I Badung, Bali. Respondents asked to fill a self-administered questionnaire from Health Belief Model to asses of respondent’s perception about HIV screening test.Result and conclusion: There are 43 pregnant women as respondents with mean age 27 years. Of 49 respondents, 71.4% is pregnant women with equal or below of high school education. 16.3% of respondents did not work and 51% have a good knowledge about HIV. Through bivariate analysis have found gestational age, education level, knowledge, and risk perception have significant associations that can included into multivariate analysis (p<0.25). From multivariate analysis, we found that risk perception have independent association to HIV test among pregnant women (p<0.05; OR 0.121; 95%CI 0.021 – 0.690). Penularan HIV kepada anak-anak atau bayi menjadi fokus permasalahan penting dalam program reduksi kasus HIV. Tujuan: Untuk mengetahui faktor yang berhubungan dengan perilaku tes HIV (human immunodeficiency virus) pada ibu hamil di Puskesmas Abiansemal I.Metode: Penelitian ini menggunakan desain cross-sectional analitik dengan purposive sampling pada sampel ibu hamil yang rutin melakukan pemeriksaan kehamilan di Wilayah Pelayanan Puskesmas Abiansemal I, Badung. Seluruh responden mengisi kuesioner adaptasi health belief model untuk menilai persepsi responden mengenai tes skrining HIV.Hasil dan simpulan: Total responden pada penelitian ini adalah 49 orang dengan rerata usia 27 tahun. Dari 49 responden tersebut, 71,4% memiliki riwayat pendidikan terakhir, yaitu di bawah atau sama dengan sekolah menengah atas (SMA). Terdapat 16,3% responden yang tidak bekerja dan 51% responden memiliki pengetahuan yang baik mengenai HIV. Melalui analisis bivariat, ditemukan bahwa usia kehamilan, tingkat pendidikan, pengetahuan, dan persepsi risiko memiliki hubungan yang dapat diinklusi dalam analisis multivariat (p<0,25). Pada analisis multivariat, ditemukan bahwa persepsi risiko memiliki hubungan independen terhadap perilaku tes HIV ibu hamil (p<0,05; OR 0,121; 95%IK 0,021 - 0,690).