bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective Mouthfeel and Temperature Alterations in COVID-19 Patients Six to Ten Months After Diagnosis
Authors: van Elst Jip M. , Boesveldt Sanne , Vissink Arjan , Jager-Wittenaar Harriët , Reyners Anna K. L. , de Haan Jacco J. 
Published: November 2022

Abstract

Introduction
The characteristics and impact of mouthfeel, temperature, smell, and taste alterations in patients with COVID-19 at a long term are yet not well known. In this study, these characteristics and their impact on daily life and quality of life (QoL) were assessed, six to ten months after infection, in patients with COVID-19 searching for peer support on Facebook.

Methods
Between December 2020 and January 2021, members of two COVID-19 Facebook groups were invited to complete a questionnaire. Participants were asked to report their perception of mouthfeel, temperature, smell, and taste alterations and their impact.

Results
The questionnaire was completed by 157/216 respondents (73%), with 92% being women. Alterations in mouthfeel, temperature, smell, and taste were reported by respectively 66, 40, 148, and 133 participants. The most frequently reported mouthfeel alterations were “a different feeling” and “dry mouth” in 38 and 30 participants, respectively. Preferences for food temperature were equally changed to “freezing”, “cool”, “room temperature”, “a bit warmer”, and “warmer”. An impact on daily life and QoL was reported by most patients with alterations in mouthfeel (91% and 79%), temperature (78% and 60%), smell (98% and 93%), and taste (93% and 88%), respectively.

Conclusions
Patients with COVID-19 searching for peer support on Facebook experienced, next to smell and taste alterations, mouthfeel and temperature disturbances, six to ten months after infection. These alterations have an impact on daily life and QoL.

Implications
Health professionals should, next to smell and taste alterations, be aware of mouthfeel and temperature alterations in patients with COVID-19.
Tribe Shoreae (Dipterocarpaceae subfamily Dipterocarpoideae) Finally Dissected
Authors: Ashton P. S. , Heckenhauer J. 
Published: November 2022

SummaryThe dipterocarp tribe Shoreae, perhaps more than any other members of this elegant family of often giant emergent trees, is familiar to all who visit the once ubiquitous lowland forests of tropical Asia. Timbers of the genusShoreacomprised the bulk of hardwood traded on international markets for thirty years, since the nineteen seventies. Distinct species groups came to be recognised by taxonomists: for their characteristic androecia, and sometimes differences in bark and wood anatomy, while generic status for some was then proposed on embryological evidence. A new molecular phylogeny of the family, and this tribe, substantially confirms the embryological case. This paper formalises resultant nomenclatural changes. Those of us who recall the majestic forested former landscapes of the Sunda lands may regret this decision. But now, with landscapes irretrievably changed by serried ranks of oil palm and forest degradation, the case for recognition of the proposed new entities can guide conservation planners in recognising and making the case for permanently conserving surviving undisturbed stands of exceptional composition or diversity.
External Comparator Groups Derived from Real-world Data Used in Support of Regulatory Decision Making: Use Cases and Challenges
Authors: Carrigan Gillis , Bradbury Brian D. , Brookhart M. Alan , Capra William B. , Chia Victoria , Rothman Kenneth J. , Sarsour Khaled , Taylor Michael D. , Brown Jefferey S. 
Published: November 2022

AbstractReal-world data (RWD) from electronic health records (EHRs) and administrative claims databases are used increasingly to generate real-world evidence (RWE). RWE is used to support clinical evidence packages for medicines that inform decision-makers. In this review of current issues in the use of RWD-derived external comparator groups to support regulatory filings, we assess a series of topics that generally apply across many disease indications. However, most of the examples and illustrations focus on the oncology clinical research setting. The topics include an overview of current uses of RWD in drug development, a discussion of regulatory filings using RWD-derived external comparators, a brief overview of guidance documents and white papers pertaining to external comparators, a summary of some limitations and methodological issues in the use of external comparator groups and finally, a look at the future of this area and recommendations.
Prevalence, incidence, and treatment of anaemia in patients with non-dialysis-dependent chronic kidney disease: findings from a retrospective real-world study in Italy
Authors: Minutolo Roberto , Grandaliano Giuseppe , Di Rienzo Paolo , Snijder Robert , Degli Esposti Luca , Perrone Valentina , Todorova Lora 
Published: November 2022

Abstract
Background
Limited data are available on the epidemiology and clinical management of anaemia in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD).

Methods
This retrospective observational study was based on records from databases of five Local Health Units across Italy. Adults with reported NDD-CKD stage 3a–5 between 1 January 2014 and 31 December 2016 were identified. Annual prevalence and incidence of anaemia (age- and sex-standardised) and clinical management (erythropoiesis-stimulating agents [ESAs], intravenous [IV] iron, and blood transfusions) were evaluated. Eligibility for ESAs was defined by ≥ 2 records of Hb < 10 g/dL, or < 11 g/dL over 6 months.

Results
Overall, 101,143 individuals with NDD-CKD (3a–5) recorded between 2014 and 2016 were identified, of whom 40,020 (39.6%) were anaemic. Prevalence of anaemia was 33.8% in 2016 and incidence of anaemia was stable (11.4–12.4%) from 2014 to 2016. Prevalence and incidence of anaemia increased with CKD stage. Among eligible patients, 12.8% with Hb < 11 g/dL and 15.5% with Hb < 10 g/dL received ESAs, and the proportion treated increased with CKD stage. Among ESA-treated patients with at least 2 years of follow up, 18.4% and 19.3% received IV iron in the Hb < 11 and < 10 g/dL groups, respectively, and 16.5% and 19.4% received blood transfusions. Corresponding proportions for the overall anaemic cohort were 9.0% and 11.3%, respectively.

Conclusions
Anaemia is a significant issue in patients with NDD-CKD. Low rates of ESA treatment indicate a potential treatment gap and suggest that anaemia may not be adequately controlled in many patients.

Graphical abstract
The first case of lipoprotein glomerulopathy complicated with collagen type III glomerulopathy and literature review
Authors: Liu Huixia , Luo Changqing , Li Zhenqiong , Zhang Chun , Xiong Jing 
Published: November 2022

AbstractLipoprotein glomerulopathy (LPG) is a rare autosomal dominant kidney disease caused by pathogenic mutations in the APOE gene. Collagen type III glomerulopathy (CG) is a sporadic condition in adults characterized by abnormal accumulation of type III collagen in the subendothelial space and mesangium of the glomerulus. We report the first case of both LPG and CG in a 21-year-old male. A search of the literature found no confirmed reports of these two concomitant nephropathies. The patient presented with hypertension, proteinuria, hematuria and hyperlipidemia. Renal pathology showed lipid vacuoles in the enlarged glomerular capillary loops and type III collagen in the segmental mesangial area and on the inner side of the glomerular basement membrane by electron microscopy. Whole-exome sequencing revealed a heterozygous mutation (c.127C>T; p. Arg43Cys) in exon 3 of the APOE gene, known as the APOE-Kyoto of LPG. In addition, two heterozygous COL4A4 mutations (c.4715C>T in exon 47 and c.5065 T>C in exon 48) were observed, the first one was suspected pathogenic and the other one was uncertain significant. There is no special treatment for these diseases. The patient was treated with lipid-lowering agents, renin–angiotensin–aldosterone system inhibition and tripterygium glycosides. The patient received double-filtration plasmapheresis and immunoadsorption therapy when renal function deteriorated dramatically. Immunoadsorption was beneficial for this patient.
Chip-Based High-Dimensional Optical Neural Network
Authors: Wang Xinyu , Xie Peng , Chen Bohan , Zhang Xingcai 
Published: November 2022

AbstractParallel multi-thread processing in advanced intelligent processors is the core to realize high-speed and high-capacity signal processing systems. Optical neural network (ONN) has the native advantages of high parallelization, large bandwidth, and low power consumption to meet the demand of big data. Here, we demonstrate the dual-layer ONN with Mach–Zehnder interferometer (MZI) network and nonlinear layer, while the nonlinear activation function is achieved by optical-electronic signal conversion. Two frequency components from the microcomb source carrying digit datasets are simultaneously imposed and intelligently recognized through the ONN. We successfully achieve the digit classification of different frequency components by demultiplexing the output signal and testing power distribution. Efficient parallelization feasibility with wavelength division multiplexing is demonstrated in our high-dimensional ONN. This work provides a high-performance architecture for future parallel high-capacity optical analog computing.
ASEAN’s energy transition: how to attract more investment in renewable energy
Authors: Vakulchuk Roman , Overland Indra , Suryadi Beni 
Published: November 2022

AbstractThe energy transition is progressing slowly in the ten member states of the Association of Southeast Asian Nations (ASEAN). To achieve ASEAN’s target of 23% renewables in the primary energy supply by 2025, the region would need to invest USD 27 billion in renewable energy every year. However, the ASEAN countries attracted no more than USD 8 billion annually from 2016 to 2021. Through a comparative review of three key factors for attracting investment—renewable energy legislation, energy governance reform, and general conditions for investors—this study examines why the region’s renewable energy sector has not attracted more capital. The contribution of the article is threefold. First, it develops a new review model for assessing the business climate for renewable energy in any country. Second, it offers an update on the state of renewable energy deployment in the ASEAN countries. Third, taking into account international best practices, it identifies the obstacles and solutions to attracting investment in renewable energy in Southeast Asia. The article finds that carbon lock-in is pervasive, regulatory practices have been copy-pasted from the fossil-fuel sector to the renewables sector, and, except for Malaysia and Vietnam, no ASEAN country has implemented a major pro-renewable energy governance reform. Certain advanced renewable energy measures, such as auctions and feed-in tariffs, have been adopted in some member states, but the institutional capacity to implement them is limited. The share of renewables in the energy governance system needs to be increased.
Plasma-based synthesis of graphene and applications: a focused review
Authors: Zafar Muhammad Adeel , Jacob Mohan V. 
Published: November 2022

AbstractGraphene is a highly sought-after material for a wide range of applications, particularly in areas such as energy harvesting and storage, electronics, electrochemical sensors, biomedical, composites, and coatings. The synthesis of high-quality graphene is a precondition for its real-time application. However, conventional synthesis methods have certain drawbacks including laborious procedures and structural defects in graphene nanosheets. Plasma-based synthesis techniques such as plasma-enhanced chemical vapor deposition and atmospheric pressure microwave plasma are high-tech synthesis practices that can produce graphene without any solvents in a few seconds. This article reviews these state-of-the-art techniques emphasizing mainly their process parameters for the synthesis of high-grade graphene, which is defect-free, and comprises mono to few layers, great carrier mobility, and high purity. The applications of as-synthesized graphene in various fields are also provided. Moreover, the potential breakthroughs and the prospect of these techniques are also discussed in this work.
Molecular and Morphological Engineering of Organic Electrode Materials for Electrochemical Energy Storage
Authors: Wu Zhenzhen , Liu Qirong , Yang Pan , Chen Hao , Zhang Qichun , Li Sheng , Tang Yongbing , Zhang Shanqing 
Published: November 2022

AbstractOrganic electrode materials (OEMs) can deliver remarkable battery performance for metal-ion batteries (MIBs) due to their unique molecular versatility, high flexibility, versatile structures, sustainable organic resources, and low environmental costs. Therefore, OEMs are promising, green alternatives to the traditional inorganic electrode materials used in state-of-the-art lithium-ion batteries. Before OEMs can be widely applied, some inherent issues, such as their low intrinsic electronic conductivity, significant solubility in electrolytes, and large volume change, must be addressed. In this review, the potential roles, energy storage mechanisms, existing challenges, and possible solutions to address these challenges by using molecular and morphological engineering are thoroughly summarized and discussed. Molecular engineering, such as grafting electron-withdrawing or electron-donating functional groups, increasing various redox-active sites, extending conductive networks, and increasing the degree of polymerization, can enhance the electrochemical performance, including its specific capacity (such as the voltage output and the charge transfer number), rate capability, and cycling stability. Morphological engineering facilitates the preparation of different dimensional OEMs (including 0D, 1D, 2D, and 3D OEMs) via bottom-up and top-down methods to enhance their electron/ion diffusion kinetics and stabilize their electrode structure. In summary, molecular and morphological engineering can offer practical paths for developing advanced OEMs that can be applied in next-generation rechargeable MIBs.
Graphical abstract
Free Rotation of a Rigid Mass Carrying a Rotor with an Internal Torque
Authors: Galal A. A. 
Published: November 2022

Abstract
Purpose
In this paper, the analytic solution for a free rotatory motion under the influence of a motor of limited power is investigated; we aim to prove that the motion of the carrier body is close to rotation about a fixed axis depending upon the problem's parameters and the initial conditions.

Method
Tensor calculus tools, asymptotic method, and kinematic equations of motion (EOM) are used.

Results
At a large time, the asymptotic properties of solutions and a system of linear differential equations that describes the approximate gyrostat motion are obtained.

Conclusion
The motion of the carrier body, which is close to the rotation around an axis, whose direction is fixed, depends upon the problem’s parameters and the initial conditions.
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction
Authors: Jastrzębska Joanna , Frankowska Małgorzata , Smaga Irena , Hubalewska-Mazgaj Magdalena , Suder Agata , Pieniążek Renata , Przegaliński Edmund , Filip Małgorzata 
Published: November 2022

Abstract
Background
Epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (CUD). The role of serotonin 2C (5-HT2C) receptors in the mechanisms responsible for the coexistence of depression and CUD was not investigated.

Methods
We combined bilateral olfactory bulbectomy (OBX), an animal model of depression, with intravenous cocaine self-administration and extinction/reinstatement in male rats to investigate two 5-HT2C receptor agonists (Ro 60-0175 (RO) and WAY 161503 (WAY)) and the 5-HT2C-receptor preferring antagonist mirtazapine (MIR; an antidepressant), with the goal of determining whether these drugs alter cocaine-induced reinforcement and seeking behaviors. Additionally, neurochemical analyses were performed following cocaine self-administration and its abstinence period in the brain structures in OBX rats and SHAM-operated controls.

Results
Acute administration of RO reduced, while WAY non-significantly attenuated cocaine reinforcement in both rat phenotypes. Moreover, RO or WAY protected against cocaine-seeking behavior after acute or after repeated drug administration during extinction training in OBX and SHAM rats. By contrast, acutely administered MIR did not alter cocaine reinforcement in both rat phenotypes, while it’s acute (but not repeated) pretreatment reduced cocaine-seeking in OBX and SHAM rats. In neurochemical analyses, cocaine reinforcement increased 5-HT2C receptor levels in the ventral hippocampus; a preexisting depression-like phenotype enhanced this effect. The 10-daily cocaine abstinence reduced 5-HT2C receptor expression in the dorsolateral striatum, while the coexistence of depression and CUD enhanced local receptor expression.

Conclusion
The results support a key role of 5-HT2C receptors for treating CUD and comorbid depression and CUD. They may be backs the further research of pharmacological strategies with drug targeting receptors.

Graphical abstract
Adverse Childhood Experiences and Medication Overuse Headache: Burden and Treatment Impact
Authors: Sandoe Claire H. , Lawler Valerie , Lena Suvendrini , Lagman-Bartolome Ana Marissa , Lay Christine 
Published: November 2022

ABSTRACT:Adverse childhood experiences (ACEs) are a risk factor for progression from episodic to chronic migraine. Risk factors for medication overuse headache (MOH) are incompletely understood, but opioid overuse may carry a higher risk than overuse of other medication types. We performed a retrospective chart review investigating the frequency and impact of ACEs in patients with MOH. Of 68 included patients, 37 (54.4%) reported ACEs. There was no significant inter-group difference in baseline migraine disability assessment (MIDAS) or monthly headache days. Patients with ACEs reported more opioid overuse, and worse headache-related disability at follow-up, despite similar monthly headache days. Patients with ACEs require complex, multidisciplinary treatment.
An approach for system analysis with model-based systems engineering and graph data engineering
Authors: Schummer Florian , Hyba Maximillian 
Published: November 2022

Abstract
Model-based systems engineering (MBSE) aims at creating a model of a system under development, covering the complete system with a level of detail that allows to define and understand its behavior and enables to define any interface and work package based on the model. Once the model is established, further benefits can be reaped, such as the analysis of complex technical correlations within the system. Various insights can be gained by displaying the model as a formal graph and querying it. To enable such queries, a graph schema is necessary, which allows to transfer the model into a graph database. In the course of this paper, we discuss the design of a graph schema and MBSE modeling approach, enabling deep going system analysis and anomaly resolution in complex embedded systems with a focus on testing and anomaly resolution. The schema and modeling approach are designed to answer questions such as What happens if there is an electrical short in a component? Which other components are now offline and which data cannot be gathered anymore? If a component becomes unresponsive, which alternative routes can be established to obtain data processed by it. We build on the use case of qualification and operations of a small spacecraft. Structural elements of the MBSE model are transferred to a graph database where analyses are conducted on the system. The schema is implemented by means of an adapter for MagicDraw to Neo4J. A selection of complex analyses is shown in the example of the MOVE-II space mission.
Ethical exit: When should peacekeepers depart?
Authors: Aloyo Eamon , Swenson Geoffrey 
Published: November 2022

AbstractWhen should peacekeepers partially or fully withdraw from a country or region in which they are operating? This important question has received little scholarly attention. However, it has profound implications. If peacekeepers depart prematurely, as happened in Rwanda in 1994, the consequences can be disastrous with the potential to lead to widespread preventable deaths and human suffering. If they overstay, peacekeepers risk alienating the population they are seeking to protect and undercutting popular sovereignty at significant economic costs. Striking a balance, we propose a framework for just withdrawal that is both normatively compelling and empirically sound. It focuses on three aspects that are vital for understanding when peacekeepers can depart in an ethically justified manner: just cause, effectiveness, and legitimacy. By considering a number of objections, we also address critics who challenge the overarching premise of peacekeeping or might prefer different standards by which to suggest peacekeepers should stay or depart. Finally, we illustrate our argument with theoretical and empirical examples and a discussion of UN peacekeeping in East Timor.
It’s Not Me, It’s You: Self-Interest, Social Affinity, and Support for Redistribution in Latin America
Authors: Borges Fabián A. 
Published: November 2022

ABSTRACTSupport for redistribution in developing countries has been found to be weakly related to income, meaning the poor are not much likelier than the rich to support redistribution. If not economic self-interest, what explains support for redistribution? A multilevel regression analysis covering a decade of public opinion data from 18 Latin American countries finds support for explanations centered on social affinity. Specifically, people in more culturally divided countries are less supportive of redistribution. This relationship is strongest among low-income individuals, who are more likely to support redistribution than richer people in countries with low levels of diversity, but no more likely and, by some measures, less likely to support redistribution where diversity is highest. Economic distance between groups also matters. Support for redistribution increases when middle-class incomes are closer to those of the poor than the rich. Support declines as the middle class pulls ahead of the poor.