bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of Daoyin and massage for lumbar disc herniation
Authors: Shi Mingpeng , Zhang Xianshuai , Wang Siyi , Li Shaojun , Zhao Changwei , Li Zhenhua , Li Jianan 
Published: February 2022

Abstract

Background:
Lumbar disc herniation (LDH) is a common disease, which can cause low back pain, sciatica, and even disability. The treatment of LDH is a global challenge. Conservative therapy with non-drugs is considered to be the first choice for patients with LDH. In recent years, an increasing number of systematic reviews and meta analyses on Daoyin and massage interventions in lumbar disc herniation have been implemented. However, the evidence quality and methodological quality of these systematic reviews/meta analyses are unknown and need to be systematically evaluated. This overview aims to systematically summarize and critically appraise the current evidence on Daoyin and massage for LDH.

Methods:
Eight electronic data will be retrieved, including China National Knowledge Infrastructure (CNKI), Wanfang database (WF), China Biomedical database (CBM), Chinese Scientific Journals Database (VIP), PubMed, Cochrane Library, Web of Science (WOS), and EMBASE from their inception to March 1, 2022. The reporting quality, methodological quality, risk of bias, quality of evidence will be assessed by using The Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 (PRISMA 2020), the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2), the Risk of Bias in Systematic Review (ROBIS), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Two independent researchers conducted literature screening, data extraction, and quality evaluation process. In addition, we will establish an overlap matrix and calculate the corrected covered area to evaluate the impact of overlapping areas on conclusions.

Results:
The results will be published in a peer-reviewed journal.

Conclusion:
This overview will provide comprehensive evidence of Daoyin and massage for treating lumbar disc herniation.

Systematic review registration:
INPLASY202210019.
Cerebellum/liver index in pretherapeutic 18F-FDG PET/CT as a predictive marker of progression-free survival in follicular lymphoma treated by immunochemotherapy and rituximab maintenance
Authors: Godard François , Durot Eric , Durot Carole , Hoeffel Christine , Delmer Alain , Morland David 
Published: February 2022

Abstract
The purpose of this study was to investigate the value of the “cerebellum/ liver index for prognosis” (CLIP) as a new prognostic marker in pretherapeutic 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with follicular lymphoma treated by immunochemotherapy and rituximab maintenance, focusing on progression-free survival (PFS).
Clinicobiological and imaging data from patients with follicular lymphoma between March 2010 and September 2015 were retrospectively collected and 5-year PFS was determined. The conventional PET parameters (maximum standardized uptake value and total metabolic tumor volume) and the CLIP, corresponding to the ratio of the cerebellum maximum standardized uptake value over the liver SUVmean, were extracted from the pretherapeutic 18F-FDG PET.
Forty-six patients were included. Eighteen patients (39%) progressed within the 5 years after treatment initiation. Five-year PFS was 78.6% when CLIP was >4.0 and 42.0% when CLIP was <4.0 (P = .04). CLIP was a significant predictor of PFS on univariate analysis (hazard ratio 3.1, P = .049) and was near-significant on multivariate analysis (hazard ratio 2.8, P = .07) with ECOG PS as a cofactor.
The CLIP derived from pretherapeutic 18F-FDG PET seems to be an interesting predictive marker of PFS in follicular lymphoma treated by immunochemotherapy and rituximab maintenance. These results should be evaluated prospectively in a larger cohort.
Acute paraparesis syndrome after ruptured anterior communicating artery aneurysm
Authors: Lee Jong-Myong 
Published: February 2022

Abstract
Here, we describe a series of 7 patients who presented with acute paraparesis due to anterior communicating artery aneurysm rupture. This study aimed to assess the clinical and radiological factors associated with acute paraparesis syndrome caused by subarachnoid hemorrhage (SAH).
Between June 2005 and December 2012, our institution consecutively treated 210 patients with anterior communicating aneurysm rupture within 24 hours after ictus. We divided the patients into 2 groups based on the presence (n = 7) and absence (n = 203) of acute paraparesis after anterior communicating aneurysm rupture.
Diffusion-weighted magnetic resonance imaging revealed high intensity in the medial aspects of the bilateral frontal lobes in 3 patients. The mean third ventricular distance at the time of admission was 9.2 mm (range, 8–12.5 mm), and the mean bicaudate distance was 33.9 mm (range, 24–39 mm). There was a significant difference in the bicaudate distance (P = .001) and third ventricle distance (P = .001) between the 2 groups. Acute hydrocephalus and global cerebral edema (GCE) were confirmed radiologically in all patients in the acute paraparesis group. The presence of acute hydrocephalus (P = .001) and GCE (P = .003) were significantly different between the groups.
Acute paraparesis syndrome after SAH is transient and gradually improves if the patient does not develop severe vasospasm. The present study demonstrates that acute paraparesis after SAH is associated with acute hydrocephalus and GCE.
Willingness to take and ever use of pre-exposure prophylaxis among female sex workers in Ghana
Authors: Guure Chris , Afagbedzi Seth , Torpey Kwasi 
Published: February 2022

Abstract
Pre-exposure prophylaxis (PrEP) is a drug taken by people who are human immunodeficiency virus (HIV) negative and at increased risk of acquiring HIV. It's an effective intervention for HIV prevention. This study seeks to report on the prevalence and determinants of willingness to take and ever use of PrEP among female sex workers (FSW) in Ghana.
The data analyzed was obtained from the Integrated Bio-behavioral Surveillance Survey conducted across the 16 regions of Ghana in 2020. Analysis was only performed on FSW who were tested negative to HIV and were sexually active. All included variables were described using medians, percentages, and graphs. Bayesian adjusted odds ratios and 95% credible intervals were estimated using a Bayesian generalized linear model via the binomial family of distributions under the logit link function.
Of the 5107 FSW with complete data on willingness to use PrEP, 2737 (53.59%) reported their willingness to take PrEP. Out of the 998 respondents who have ever heard of PrEP only 64 (6.39%) have ever used PrEP. The median age of the respondents was 25 years. People with no comprehensive knowledge of HIV and acquired immunodeficiency syndrome as well as those who entered into the FSW business at age less than 25 years; 946 (34.56%) and 2181 (79.65%) respectively were more willing to take PrEP. FSW from 6 out of the 16 regions of Ghana have never used PrEP. A statistically significant difference between those who entered the sex work at age less than 25 years and those within 25 to 34 years was observed. About 23% of FSWs who had been screened for Sexually Transmitted Infections were more likely to take PrEP.
Respondents with lesser age and no comprehensive knowledge of HIV were more willing to take PrEP. The willingness to accept PrEP among FSWs in Ghana is modest. However, utilization is low. Advocacy or intervention programs are required to improve uptake of PrEP.
Dedicator of cytokinesis 8 deficiency and hyperimmunoglobulin E syndrome
Authors: Wang Zhaojun , Zhang Yanan , Li Gang , Huang Lingyan , Chen Juan 
Published: February 2022

Abstract

Rationale:
Hyperimmunoglobulin E syndrome (HIES) is a rare and complex immunoregulatory multisystem disorder characterized by recurrent eczema, skin and sinopulmonary infections, elevated serum immunoglobulin E levels, and eosinophilia. Onset is most likely in childhood, although infrequent adult cases have been reported. Early diagnosis is important. The use of the National Institutes of Health scoring system and the HIES signal transducer and activation of transcription 3 score can standardize the diagnosis of HIES.

Patient concerns:
A 19-year-old woman presented with complaints of dry cough, pyrexia, dyspnea, and recurrent pneumonia. She had a history of milk allergy, recurrent eczema, suppurative otitis media, chalazia, and aphthous ulcers. Her parents had a consanguineous marriage.

Diagnosis:
HIES; severe pneumonia.

Interventions:
Voriconazole (200 mg iv 2 times/d) and flucytosine (1 g orally 4 times/d) for 3 weeks were administered, followed by oral administration of fluconazole for 3 weeks.

Outcomes:
The patient experienced near-complete remission of her respiratory symptoms. The patient was followed-up for one and a half years. During the follow-up, the patient presented again with cough and dyspnea and was again admitted to hospital. After being hospitalized for 3 weeks of antibiotic treatment, the patient experienced near-complete relief of her respiratory symptoms.

Lessons:
Regardless of patient age, it is important to consider the possibility of HIES when a patient has recurrent eczema, skin and sinopulmonary infections, elevated serum immunoglobulin E levels, and eosinophilia. Early diagnosis and intervention are essential to improve prognosis.
A Meta-Analysis of the Effectiveness of Cognitive Rehabilitation in Improving Memory Function in Patients With Posttraumatic Stress Disorder
Authors: Zare Somayeh , Zare Hossein , Farzad Valiollah , Alipoor Ahmad 
Published: February 2022

Abstract
Posttraumatic stress disorder (PTSD) may have a detrimental effect on a patient's memory function. Memory problems are common after PTSD and can cause problems with a patient's day-to-day life. Cognitive rehabilitation is considered an effective treatment for patients with PTSD who want to improve cognitive memory. We searched keywords in electronic databases to find studies that looked into the effect of cognitive rehabilitation on memory function in patients with PTSD. This report is based on data from four studies with double-blind and placebo-controlled experiments totaling 198 participants. Effect size estimates were calculated using a mixed-effects meta-analysis for memory function. During cognitive rehabilitation, patients with PTSD demonstrated gains in memory in a variety of ways. Our results pointed to the need for further research into the most promising interventions for improving memory function in patients with PTSD. Furthermore, well-designed studies with large sample sizes are needed to confirm our results and determine the magnitude of the problem.
Clinicopathological Analysis of 907 Major and Minor Salivary Gland Tumors
Authors: Dimitrijevic Milovan V. , Boricic Ivan V. , Tomanović Nada R. , Dimitrijevic Ana M. , Bjelogrlić Goran M. , Krstić Aleksandar M. , Stojkovic Goran M. , Rajovic Nina Z. , Djordjevic Ivana P. Mitrovic , Djurkovic Petar M. 
Published: February 2022

Purpose:
The frequency and types of salivary gland tumors show significant geographical variations. The most common are primary epithelial tumors, with pleomorphic adenoma and mucoepidermoid carcinoma being the most frequent. This study aims to analyze the clinicopathological data of patients with major and minor salivary gland (MiSG) tumors.

Methods:
The retrospective study included all patients with major and MiSG tumors diagnosed and treated between January 2000 and January 2019. Files of 907 patients were reviewed and investigated for clinicopathologic features of major and MiSG tumors in Serbia.

Results:
The majority of tumors were of epithelial origin. Pleomorphic adenoma was the predominant type of tumor, with 35.1% among all tumors on all sites. Adenoid cystic carcinoma and mucoepider-moid carcinoma (with 7.1% and 2.7%, respectively) were the most common malignant ones. The most common localization was the parotid gland. Minor salivary gland tumors comprised 16.43% of all salivary gland tumors in our series, the most common localization being the oral cavity. The results of our study are mostly consistent with the results of other previously published studies.

Conclusions:
The most important finding, worth emphasizing, is that the most common malignant major and MiSG tumor in our population is adenoid cystic carcinoma, rather than mucoepidermoid carcinoma, in all investigated localizations. In addition, the nasal cavity is the most common localization among malignant MiSG tumors.
Prosthetic Materials Protrusion After Surgical Wall Reconstruction of Temporomandibular Joint Herniation
Authors: Baeg Moon Seung , Moon Seong Kyu , Cho Hyun Sang 
Published: February 2022

Abstract:
Herniation of the temporomandibular joint (TMJ) into the external auditory canal (EAC) is rare. The TMJ and EAC are separated by the anterior bony wall of the EAC. Such a defect can be caused by trauma, infection, neoplasm, inflammation, and in rare cases, congenital bony defects. If asymptomatic or mildly symptomatic, supplemental treatment is primarily given, but if the symptoms are severe enough that the patient regularly feels discomfort, surgical procedure is considered. To our knowledge there are no reports about surgery-related complications and recurrence during the postoperative follow-up period for TMJ herniation in English literature. Here, the authors report the first case of implant protrusion after TMJ herniation surgery along with a literature review.
Anthropometric Periocular Soft Tissue Analysis From Preadolescence to Young Adulthood: Photogrammetric Measurements
Authors: Ozdemir Fikri , Golpinar Murat , Nahir Mert , Sahin Bunyamin 
Published: February 2022

Abstract:The periocular region has a central role in the prediction of ethnicity, understanding emotional expression, age, and sex. The aim of this study was to determine the sex-related growth changes in the periocular region of Turkish preadolescents, adolescents, and young adults. The study included a total of 234 individuals (preadolescents: 34 females and 40 males; adolescents: 40 females, 40 males, and young adults: 40 males and 40 females). A total of 7 periocular parameters (3 bilateral, 3 unilateral linear, and 1 angular measurement) were analyzed statistically to determine sex-related differences. The palpebral fissure and canthal indexes were also calculated. Of the 14 periocular measurements, 9 were found to be sexually dimorphic in certain age groups (P <0.05). Right-left palpebral fissure width and left palpebral fissure height were significantly different between young adult males and females (P= 0.018,P= 0.013, andP= 0.027, respectively). A significant sexual dimorphism was observed for outercanthal distance and canthal index in 3 age groups (P< 0.05). The data collected in this study may serve as a sex-dependent database source for the Turkish population during normal growth from preadolescence to young adulthood. The present study results would be useful for planning and designing aesthetic and post-traumatic surgical interventions in the periocular region as well as personal identification in this population.
Complications According to the Handling of the Pterygoid Plate During Bimaxillary Surgery
Authors: Moon Chiho , Park Jin-Young , Choi Na-Rae , Kang Young-Hoon , Jaiswal M. Shriya , Jang Hun , Hwang Dae Seok 
Published: February 2022

Background:
During bimaxillary surgery, manipulation of the pterygoid plate is required to facilitate movement of the maxilla. This study examined the complications that occurred after handling the pterygoid plate during a Le Fort I osteotomy.

Patients and Methods:
This study compared and analyzed complications according to the pterygoid plate handling method in 80 patients who underwent bimaxillary surgery at Pusan National University Dental Hospital from December 2015 to July 2020. The pterygoid plate was fractured or removed intentionally only if it interfered with the maxilla. Otherwise, it was not treated. The complications during surgery and the follow-up period were investigated.

Results:
Fourteen patients experienced complications, of which excessive bleeding, hearing problems, and nonunion were encountered in 10, 2, and 2 patients, respectively. Of the 10 patients with excessive bleeding patients, the pterygoid plate was manipulated in 8 patients, which was controlled during surgery. Two patients complained of hearing loss with ear congestion immediately after surgery; both patients improved spontaneously within 1 month. Two nonunion patients underwent plate refixation at least 6 months postoperatively, and normal healing was achieved afterward.

Conclusions:
Fracture and removal of the pterygoid plate during orthognathic surgery did not significantly affect the occurrence of complications during and after surgery.
Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers
Authors: Cheedarla Narayanaiah , Verkerke Hans P. , Potlapalli Sindhu , McLendon Kaleb Benjamin , Patel Anamika , Frank Filipp , Damhorst Gregory L. , Wu Huixia , O’Sick William Henry , Graciaa Daniel , Hudaib Fuad , Alter David N , Bryksin Jeannette , Ortlund Eric A. , Guarner Jeanette , Auld Sara , Shah Sarita , Lam Wilbur , Mattoon Dawn , Johnson Joseph M , Wilson David H , Dhodapkar Madhav V. , Stowell Sean R. , Neish Andrew S. , Roback John D. 
Published: February 2022

AbstractTraditional cellular and live-virus methods for detection of SARS-CoV-2 neutralizing antibodies (nAbs) are labor- and time-intensive, and thus not suited for routine use in the clinical lab to predict vaccine efficacy and natural immune protection. Here, we report the development and validation of a rapid, high throughput method for measuring SARS-CoV-2 nAbs against native-like trimeric spike proteins. This assay uses a blockade of hACE-2 binding (BoAb) approach in an automated digital immunoassay on the Quanterix HD-X platform. BoAb assays using vaccine and delta variant viral strains showed strong correlation with cell-based pseudovirus and live-virus neutralization activity. Importantly, we were able to detect similar patterns of delta variant resistance to neutralization in samples with paired vaccine and delta variant BoAb measurements. Finally, we screened clinical samples from patients with or without evidence of SARS-CoV-2 exposure by a single-dilution screening version of our assays, finding significant nAb activity only in exposed individuals. In principle, these assays offer a rapid, robust, and scalable alternative to time-, skill-, and cost-intensive standard methods for measuring SARS-CoV-2 nAb levels.
Discovery of a new but established population of the guppy in Germany
Authors: Bierbach David , Schutz Christopher , Weimar Nils , Alegre Alessandra Escurra , Francisco Fritz A. , Wersing Serafina , O’Connor Olivia L. , Kempkes Michael , Rose Udo , Miesen Friedrich Wilhelm , Habedank Marie , Jourdan Jonas , Kabus Jana , Hof Delia , Hornung Simon , Emde Sebastian , Rüffert Leon , Lukas Juliane 
Published: February 2022

AbstractFeral populations of tropical fish species in temperate climates like Central Europe are a rare but repeatedly observed phenomenon. Due to the influence of industrial or geothermal heated water, released tropical fish may be able to survive harsh winter conditions. Here we characterize a newly discovered thermally polluted river, with an established population of the guppy (Poecilia reticulata) co-occurring with native species. Through a mark-recapture approach, we estimated the population size of the guppies close to the warm water inflow to be around 2000 individuals during summer and we further provide descriptive demographics of this population which allow us to assume it is well established in that river. Further, we found some of the sampled specimen being parasitized by Camallanus roundworms, thus showing the guppies’ host potential for this genus of internal parasites. The popularity and widespread distribution of guppies as ornamental fish often leads to their intentional or unintentional release into the wild where they are often pioneer species in anthropogenically heavily modified habitats. Guppies threaten native species through niche competition and transmission of diseases. Accordingly, early awareness and knowledge on the status of non-native populations is crucial for effective management strategies.
Describing Chemical Kinetics in the Time Dimension with Mean Reaction Time
Authors: Park Chiwook 
Published: February 2022

ABSTRACTThe chemical kinetics is such a fundamental topic in chemistry. By analyzing how the experimental conditions and parameters influence the reaction rate, chemists have deciphered the molecular details on how the chemical reactions occur. The quantitative analysis of the reaction rate requires the formulation of the rate equation, which describes the dependence of the reaction rate on the concentrations of the reactants and also the rate constants of the elementary steps. Though the methods to derive the rate equation from the kinetic model have been known for a century, it is still mathematically challenging to derive the rate equation for complex reactions with multiple steps, which requires a solution for simultaneous differential equations. Therefore, chemists frequently resort to the steady-state approximation or the numerical simulation. One way to avoid the mathematical difficulty is to describe the chemical kinetics in the time dimension. Describing the mean reaction time, the average of the time required for the completion of the chemical reaction, using the elementary rate constants of the kinetic model is much simpler mathematically than deriving the rate equation for the kinetic model. Here, we describe the basic rules for the derivation of the formula of the mean reaction time, derive the generalized equation for the mean reaction time, and analyze the components of the formula to determine how the individual steps in the complex reaction contribute to the mean reaction time. Being the ensemble-averaged value, the mean reaction time does not provide the information on the actual distribution of the reaction time of individual chemical entity. However, the formula of the mean reaction time reveals invaluable insights on how the energy levels of the ground state and the transition states affect the kinetics of the complex reaction and offers a way to identify the most time-consuming process of the complex reaction in a straightforward manner. We also apply the mean reaction time to enzyme kinetics and demonstrate that one can derive the expressions of the kinetic parameters (kcat/KM and kcat) in a surprisingly simple way even without resorting to the steady-state application.