bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of psychosocial factors on nonadherence to ART in Ganta, Nimba county, Liberia
Authors: Strother Philomena J. , Tipayamongkholgul Mathuros , Kosaisevee Varakorn , Suwannapong Nawarat 
Published: June 2022

Abstract
Background
It has been widely noted that lifetime adherence to antiretroviral therapy (ART) is necessary for HIV treatment outcome; however, retention on ART among people living with HIV (PLWH) remains a great challenge to achieve the Global AIDS Strategy: End inequalities, End AIDS. Nonadherence to ART is one of the HIV care problem in Liberia despite the availability of free ART. Psychosocial factors, i.e., perceived stigma and social support likely contributed to nonadherence to ART. We investigated associations among clinical factors, psychosocial factors, and nonadherence to ART.

Methods
A community-based cross-sectional study was conducted among 185 PLWH, age ≥ 18 years receiving ART in Ganta, Nimba county, Liberia at least 3 months. The structured questionnaire was used to collect data from April to May 2020. Associated factors of nonadherence to ART were identified using multivariable binary logistic regression, and the p-value < 0.05 was considered statistically significant.

Results
Of 185 respondents, 62.2% showed nonadherence to ART. Females reported higher nonadherence compared with males (64.4% vs. 56.6%). Multivariable binary logistic regression revealed strong experiences of stigma (PORadj = 2.392, p-value = 0.018), poor information support (PORadj = 2.102, p-value = 0.026) increased prevalence of ART nonadherence among Liberian PLWH.

Conclusions
The healthcare providers may apply interventions to reduce perceived stigma and to enhance continuous information provision in addition to support from health care providers and family members. An intensive monitoring of ART side effects is needed to be strengthened in particular among newly started ART patients.
Recurrent parvovirus B19 viremia resulting in two episodes of hemophagocytic lymphohistiocytosis
Authors: Orth Hans Martin , Fuchs Andre , Lübke Nadine , Jensen Björn-Erik Ole , Luedde Tom 
Published: June 2022

Abstract
Background
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition with uncontrolled activation of lymphocytes and macrophages. Besides a primary (genetic) form, HLH can also be triggered by malignant, autoimmune and infectious diseases. HLH recurrences are rarely described, usually only in primary HLH. Parvovirus B19 (PVB19) Infection is one of the rare and rather benign causes of HLH. Since the infection usually results in long-lasting immunity, recurrent viremia is very uncommon.

Case presentation
We report an unusual case of a young female with recurrent PVB19 infection that led to repeated episodes of HLH. The first episode occurred at the age of 25 years with a three-week history of high fever and nonspecific accompanying symptoms. The diagnosis of HLH was confirmed by HLH-2004 criteria and HScore, PVB19 viremia was detected as underlying cause. Following guideline-based therapy, the patient was symptom-free for one year, before similar symptoms recurred in a milder form. Again, PVB19 was detected and HLH was diagnosed according to HScore. After successful treatment and a nine-month symptom-free interval, a third phase of hyperinflammation with low PVB19 viremia occurred; this time, treatment with a corticosteroid and intravenous immunoglobulin was initiated before the presence of clear diagnostic criteria for HLH. No further events occurred in the following three years.

Conclusions
In the case of our patient, the recurrent viremia triggered three episodes of hyperinflammation, two of which were clearly diagnosed as HLH. To our knowledge, this is the first published case of recurrent HLH due to PVB19 infection. Therefore, the case gives new insights in triggering mechanisms for HLH.
Phyllotaxis transition over the lifespan of a palm tree using Magnetic Resonance Imaging (MRI) and Terrestrial Laser Scanning (TLS): the case of Jubaea chilensis
Authors: Guzmán Eduardo , Fernández M. Paulina , Alcalde José-Antonio , Contreras Samuel , Raumonen Pasi , Picco Lorenzo , Montalba Cristián , Tejos Cristián 
Published: June 2022

AbstractBackgroundJubaea chilensis(Molina) Baillon, is a uniquely large palm species endemic to Chile. It is under threatened status despite its use as an ornamental species throughout the world. This research seeks to identify the phyllotaxis of the species based on an original combination of non-destructive data acquisition technologies, namely Magnetic Resonance Imaging (MRI) in saplings and young individuals and Terrestrial Laser Scanning (TLS) in standing specimens, and a novel analysis methodology.ResultsTwo phyllotaxis parameters, parastichy pairs and divergence angle, were determined by analyzing specimens at different developmental stages. Spiral phyllotaxis patterns ofJ. chilensisprogressed in complexity from parastichy pairs (3,2) and (3,5) in juvenile specimens and (5,3), (8,5) and (8,13) for adult specimens. Divergence angle was invariable and averaged 136.9°, close to the golden angle. Phyllotactic pattern changes associated with establishment phase, the adult vegetative and the adult reproductive phases were observed. Both technologies, MRI and TLS proved to be adequate for the proposed analysis.ConclusionsUnderstanding phyllotactic transitions may assist identification of developmental stages of wildJ. chilensisspecimens.The proposed methodology may also be useful for the study of other palm species.
Effect of sarcopenia in predicting postoperative mortality in emergency laparotomy: a systematic review and meta-analysis
Authors: Yang Tao-ran , Luo Kai , Deng Xiao , Xu Le , Wang Ru-rong , Ji Peng 
Published: June 2022

Abstract
Background
While emergency laparotomy has been associated with high rates of postoperative mortality and adverse events, preoperative systematic evaluation of patients may improve perioperative outcomes. However, due to the critical condition of the patient and the limited operation time, it is challenging to conduct a comprehensive evaluation. In recent years, sarcopenia is considered a health problem associated with an increased incidence of poor prognosis. This study aimed to investigate the effect of sarcopenia on 30-day mortality and postoperative adverse events in patients undergoing emergency laparotomy.

Methods
We systematically searched databases including PubMed, Embase, and Cochrane for all studies comparing emergency laparotomy in patients with and without sarcopenia up to March 1, 2022. The primary outcome was of 30-day postoperative mortality. Secondary outcomes were the length of hospital stay, the incidence of adverse events, number of postoperative intensive care unit (ICU) admissions, and ICU length of stay. Study and outcome-specific risk of bias were assessed using the Quality in Prognosis Studies (QUIPS) tool. We rated the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE).

Result
A total of 11 eligible studies were included in this study. The results showed that patients with sarcopenia had a higher risk of death 30 days after surgery (OR = 2.42, 95% CI = 1.93–3.05, P < 0.00001). More patients were admitted to ICU after surgery (OR = 1.58, 95% CI = 1.11–2.25, P = 0.01). Both the ICU length of stay (MD = 0.55, 95% CI = 0.05–1.06, P = 0.03) and hospital length of stay (MD = 2.33, 95% CI = 1.33–3.32, P < 0.00001) were longer in the sarcopenia group. The incidence of postoperative complications was also significantly higher in patients with sarcopenia (OR = 1.78, 95% CI = 1.41–2.26, P < 0.00001).

Conclusion
In emergency laparotomy, sarcopenia was associated with increased 30-day postoperative mortality. Both the lengths of stay in the ICU and the total length of hospital stay were significantly higher than those in non-sarcopenic patients. Therefore, we concluded that sarcopenia can be used as a tool to identify preoperative high-risk patients, which can be considered to develop new postoperative risk prediction models.
Registration number Registered on Prospero with the registration number of CRD42022300132.
A direct referencing method of the tibial plateau for the posterior tibial slope in medial unicompartmental knee arthroplasty
Authors: Akagi Masao , Aya Hisafumi , Mori Shigeshi , Syogaku Nobuhisa , Tsukamoto Ichiro , Moritake Akihiro 
Published: June 2022

Abstract
Purpose
There is no consensus on intraoperative references for the posterior tibial slope (PTS) in medial unicompartmental knee arthroplasty (UKA). An arthroscopic hook probe placed on the medial second quarter of the medial tibial plateau (MTP) in an anteroposterior direction may be used as a direct anatomical reference for the PTS. The purpose of this study is to investigate the availability and accuracy of this method.

Methods
Marginal osteophyte formation and subchondral depression of the MTP and angles between the bony MTP and the cartilage MTP were retrospectively evaluated using preoperative sagittal MRI of 73 knees undergoing medial UKA. In another 36 knees, intraoperative lateral knee radiographs with the probe placed on the MTP were prospectively taken in addition to the preoperative MRI. Then, angles between the bony MTP and the probe axis and angles between the preoperative bony MTP and the postoperative implant MTP were measured.

Results
Among 73 knees, one knee with grade 4 osteoarthritis had a posterior osteophyte higher than the most prominent point of the cartilage MTP. No subchondral depression affected the direct reference of the MTP. The mean angle between the bony MTP and the cartilage MTP was −0.8° ± 0.7° (−2.6°–1.0°, n = 72), excluding one knee with a “high” osteophyte. The mean angle between the bony MTP and the probe axis on the intraoperative radiograph was −0.6° ± 0.4° (−1.7–0.0, n = 36). The mean angle between the pre- and postoperative MTP was −0.5° ± 1.5° (−2.9°–1.8°). The root-mean-square (RMS) error of these two PTS angles was 1.6° with this method.

Conclusion
Cartilage remnants, osteophyte formation and subchondral bone depression do not affect the direct referencing method in almost all knees for which medial UKA is indicated. When the posterior “high” osteophyte of the MTP is noted on preoperative radiography, preoperative MRI or CT scan is recommended to confirm no “high” osteophyte on the medial second quarter. The accuracy of this method seems equal to that of robotic-assisted surgery (the RMS error in previous reports, 1.6°–1.9°).
Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome
Authors: Rosenfeld Elizabeth , Nanga Ravi Prakash Reddy , Lucas Alfredo , Revell Andrew Y. , Thomas Allison , Thomas Nina H. , Roalf David R. , Shinohara Russell T. , Reddy Ravinder , Davis Kathryn A. , De León Diva D. 
Published: June 2022

Abstract
Background
Hyperinsulinism hyperammonemia (HI/HA) syndrome is caused by activating mutations in GLUD1, encoding glutamate dehydrogenase (GDH). Atypical absence seizures and neuropsychological disorders occur at high rates in this form of hyperinsulinism. Dysregulated central nervous system (CNS) glutamate balance, due to GDH overactivity in the brain, has been hypothesized to play a role. This study aimed to describe the neurologic phenotype in HI/HA syndrome and investigate CNS glutamate levels using glutamate weighted chemical exchange saturation transfer magnetic resonance imaging (GluCEST MRI). In this cross-sectional study, 12 subjects with HI/HA syndrome had plasma ammonia measurement, self- or parent-completed neurocognitive assessments, electroencephalogram (EEG), and GluCEST MRI at 7 T performed. GluCEST MRI measures were compared to a historic reference population of 10 healthy adults.

Results
Subjects were five males and seven females with median age of 25.5 years. Seventy-five percent of subjects reported a history of neurodevelopmental problems and 42% had neurocognitive assessment scores outside the normal range. Fifty percent had interictal EEG findings of generalized, irregular spike and wave discharges. Higher variability in hippocampal GluCEST asymmetry (p = 0.002), and in peak hippocampal GluCEST values (p = 0.008), was observed in HI/HA subjects (n = 9 with interpretable MRI) compared to the healthy reference population (n = 10).

Conclusions
The high prevalence of abnormal neurocognitive assessment scores and interictal EEG findings observed highlights the importance of longitudinal neuropsychological assessment for individuals with HI/HA syndrome. Our findings demonstrate the potential application of GluCEST to investigate persistent knowledge gaps in the mechanisms underlying the unique neurophenotype of this disorder.
Determination of total phenolic content and antioxidant activity of Commiphora mollis (Oliv.) Engl. resin
Authors: Molole Guyo Jilo , Gure Abera , Abdissa Negera 
Published: June 2022

AbstractIn this study, total phenolic contents (TPC) and antioxidant activity of Commiphora mollis (Oliv.) Engl. (Burseraceae) resin were investigated. The resin was extracted using petroleum ether, chloroform, and methanol to give 27.46 ± 0.48, 46.56 ± 0.42, and 53.00 ± 1.39% extractable solids, respectively. The Folin–Ciocalteu (F–C) redox assay was optimized considering relevant parameters such as reaction time, maximum wavelength, and sample dilution effect before the determination of TPC. The concentration of antioxidants necessary to decrease by 50% the initial concentration of DPPH (EC50) was determined at 60 min. The reaction kinetics was analyzed using the pseudo-first-order kinetics model. For the F–C assay, the optimum conditions for the maximum absorbance and analysis time were 760 nm and 30 min, respectively. Under these conditions, the method exhibited good sensitivity and linear instrumental responses over wide ranges of concentrations. The highest TPC;168.27 ± 3.44, 137.43 ± 1.32, and 136.16 ± 0.42 mgGAE/g were recorded in the diluted samples (500 µg/mL) of methanol, chloroform, and petroleum ether extracts, respectively. By using different concentrations of the test sample, exhaustive reduction of phenolics and/or antioxidant substrates was achieved. Regarding the DPPH radical scavenging capacity, the EC50 values for methanol, chloroform, and petroleum ether extracts were 295.03 ± 3.55, 342.75 ± 9.72, and 353.69 ± 7.30 µg/mL, respectively. The standard (l-ascorbic acid), however, exhibited much lower EC50 value (44.72 ± 0.48 µg/mL). The methanol extracts showed kinetic behavior (k2 values,115.08 to 53.28 M−1 s−1; steady-state time, < 29 min) closer to that of l-ascorbic acid (k2 values, 190 to 109 M−1 s−1; steady-state time, < 16 min), than other two extracts (k2 values,14 to 28 M−1 s−1; steady-state time, 63 to 130 min). For all tested samples, the rate of the DPPH radical scavenging increases with concentration from 50 to 250 µg/mL. The current study demonstrated that the polar solvent (methanol) extract has a better F–C reducing capacity and DPPH radical scavenging activity than the nonpolar solvents extracts. This could be due to phenolics and other oxidation substrates extracted by methanol from the C. mollis resin. For a better understanding of the antioxidant constituents of the resin, a further study including isolation of its compounds is recommended.
Characteristics of internal oblique muscle strain in professional baseball players: a case series
Authors: Komatsu Shuro , Kaneko Hironori , Nagashima Masaki 
Published: June 2022

Abstract
Background
Internal oblique muscle strains can develop in professional baseball players, rendering the players unable to continue playing for a certain period. However, the characteristics of this injury are not well known. The purpose of the present study was to investigate the details of the injury and the post injury course of internal oblique muscle strain in professional baseball players.

Methods
The subjects were members of a single Japanese professional baseball team with a total of 188 players (81 fielders and 107 pitchers) who developed internal oblique muscle strains from January 2012 to December 2021. The diagnosis of muscle strain was made on the basis of local pain and magnetic resonance imaging findings. The incidence of internal oblique muscle strain, the details of the site of the injury, and the time to return to play were examined.

Results
There were 28 cases in 23 players (12.2%) of internal oblique muscle strain. The players were 16 fielders (24.7%) and 7 pitchers (7.5%), with a significantly greater incidence in fielders (p = 0.001). Although internal oblique muscle strain was more common on the side contralateral to the batting or pitching side, it occurred on either side. Most of the injury sites were at the region of the muscle insertion to the lower ribs. At a mean time of 36.5 months after the initial injury, 5 players (21.7%) developed another internal oblique muscle strain. The mean time to return to play was 27.7 ± 9.7 days (range, 4–53 days).

Conclusions
Baseball players who have symptoms at the side of the trunk should be regarded as having possible internal oblique muscle strain, and proactive examination should be considered.
Fossil fuel dependence and energy insecurity
Authors: Mayer Adam 
Published: June 2022

Abstract
Background
Access to reliable energy services is increasingly seen as a prerequisite for well-being and human development. Copious research documents the negative consequences that occur when nations specialize in natural resource production, creating a “natural resource curse” or “paradox of plenty”. In this analysis, we evaluate how natural resource dependence, measured as oil and gas production, impacts energy security.

Results
Using entropy-balanced fixed effects models, we find that oil and coal production is not associated with shorter times to establish a connection to the electricity grid, fewer outages, or improve electricity access among the population.

Conclusions
Nations that produce oil and coal do not seem to have better energy insecurity as a result, representing a distributional inequality. Fossil fuel-producing nations should consider implementing policies that would allow them to retain more wealth from fossil fuel production.
Protective and health-promoting impact of Washingtonia filifera oil on the kidney of STZ-induced diabetic mice
Authors: El-Beeh Mohamed E. , El-Badawi Ashraf A. , Qari Sameer H. , Ramadan Mohamed Fawzy , Filfilan Wessam M. 
Published: June 2022

AbstractDiabetes kidney damage (DKD) is a chronic inflammatory disease of the kidney induced with continuous hyperglycemia as the most prevalent consequence of diabetes. Washingtonia filifera seed oil (WFO) was used as a traditional medicine to cure various diseases in ancient Saudi. This work was carried out to investigate the potential protective impact of WFO against DKD on streptozotocin (STZ)-induced type 2 diabetic mice (C57BL/6 mice). The mice were randomly split into groups: C, C + WFO (200 mg/Kg B.W.), T2D, and T2D + WFO (200 mg/Kg B.W.). Diabetes was created in mice groups except for the control group after 6 weeks of high-fat diet (HFD) feeding. Treatments with STZ (60 mg/kg body weight) were administered three times for 6 weeks, and after that, mice were sacrificed. Kidney tissues and serum were obtained to analyze levels of insulin, metabolism of lipids [triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and free fatty acids (FFA)], antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)], creatine, and blood urea nitrogen (BUN). In addition, H&E staining had been used to investigate the histological changes of the kidneys. In T2D mice, WFO corrected aberrant serum lipids (TG, TC, HDL, LDL, and FFA), elevated antioxidative enzyme levels (CAT, SOD, and GPx), and inhibited GST to various degrees. In addition, WFO improves kidney pathological traits such as fibrosis of the kidney, hypertrophy of glomeruli, and basement membrane thickness of glomeruli. Through hypoglycemic, hypolipidemic, antioxidative, and anti-inflammatory actions, WFO might ameliorate diabetic alterations in T2D mice. WFO could significantly reduce AGE buildup in the T2D mice kidneys, therefore alleviating kidney oxidative stress and inflammatory kidney damage.
Soil-derived bacteria endow Camellia weevil with more ability to resist plant chemical defense
Authors: Zhang Shouke , Li Zikun , Shu Jinping , Xue Huaijun , Guo Kai , Zhou Xudong 
Published: June 2022

Abstract
Background
Herbivorous insects acquire their gut microbiota from diverse sources, and these microorganisms play significant roles in insect hosts’ tolerance to plant secondary defensive compounds. Camellia weevil (Curculio chinensis) (CW) is an obligate seed parasite of Camellia oleifera plants. Our previous study linked the CW’s gut microbiome to the tolerance of the tea saponin (TS) in C. oleifera seeds. However, the source of these gut microbiomes, the key bacteria involved in TS tolerance, and the degradation functions of these bacteria remain unresolved.

Results
Our study indicated that CW gut microbiome was more affected by the microbiome from soil than that from fruits. The soil-derived Acinetobacter served as the core bacterial genus, and Acinetobacter sp. was putatively regarded responsible for the saponin-degradation in CW guts. Subsequent experiments using fluorescently labeled cultures verified that the isolate Acinetobacter sp. AS23 can migrate into CW larval guts, and ultimately endow its host with the ability to degrade saponin, thereby allowing CW to subsist as a pest within plant fruits resisting to higher concentration of defensive chemical.

Conclusions
The systematic studies of the sources of gut microorganisms, the screening of taxa involved in plant secondary metabolite degradation, and the investigation of bacteria responsible for CW toxicity mitigation provide clarified evidence that the intestinal microorganisms can mediate the tolerance of herbivorous insects against plant toxins.