bluuebunny/crossref_metadata_2025_split huggingface dataset:
1492-PUB: In Silico Modeling of the Performance of a Novel Closed-Loop Algorithm Using the UVA/PADOVA Type 1 Diabetes Simulator
Authors: DEDESHKO ALEXEY J. , FEDOTOV VITALY , SIMIC AMRA , THIVOLET CHARLES , MADER JULIA K. 
Published: June 2022

AIAPS is a novel smartphone-based closed-loop algorithm in development that can be combined with any insulin pump and continuous glucose monitor. AIAPS strives to reduce burden of diabetes by requiring only limited input and by handling unannounced meals. Prior to launching the clinical research program in-silico modelling of the most recent features was performed. The objective of this study was to evaluate the AIAPS performance using the UVA/PADOVA Type 1 Diabetes (T1D) Simulator in people with T1D.
AIAPS was used in the in-silico population of 33 subjects (children, adolescents, and adults) of the UVA/PADOVA T1D Simulator. Upon initialisation, 5 min CGM data, body weight, average daily insulin dose and sex for each person was available. To model a scenario with limited information for each individual upon initialization, no data on basal insulin profiles (BIP) , carbohydrate-to-insulin ratio (CR) and insulin sensitivity factor (ISF) were put into AIAPS. Additionally, no information on meals (time or carbohydrate content) were put into AIAPS. The following scenario was modelled: 84 days of closed-loop therapy without user interaction and with variable routine conditions representing the duration of the planned clinical study.
Data on glycemic control for the three age groups over the 84 days are shown in table 1. Modelling included 2-5 unannounced meals with a random schedule and carbohydrate content of 130-250 g per day.
In an in-silico model the AIAPS closed-loop system exceeded current glycemic targets with a TIR &gt;70% and a TBR &lt;4% in all age groups without user interaction or input of BIP, CR and ISF upon initialization. The next step includes testing the AIAPS performance in a randomized controlled trial.
Table 1 - Glycemic control for the three age groups. Data are mean standard deviation.

Disclosure
A.J.Dedeshko: Stock/Shareholder; AI APS France. V.Fedotov: Stock/Shareholder; AIAPS France. A.Simic: None. C.Thivolet: Board Member; Insulet Corporation, Medtronic, Research Support; Abbott Diabetes, Lilly Diabetes, Novo Nordisk A/S, Sanofi. J.K.Mader: Advisory Panel; Abbott Diabetes, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Medtronic, Merck Sharp & Dohme Corp., Novo Nordisk A/S, Roche Diabetes Care, Sanofi-Aventis Deutschland GmbH, Speaker's Bureau; Abbott Diabetes, Eli Lilly and Company, Medtronic, Merck Sharp & Dohme Corp., Novo Nordisk A/S, Roche Diabetes Care, Sanofi-Aventis Deutschland GmbH, Servier Laboratories, Stock/Shareholder; decide Clinical Software GmbH.
1493-PUB: Effects of Semaglutide on Body Composition in Obese and Diabetic Patients Attended in Internal Medicine Wards
Authors: GOMEZ JUANA CARRETERO , LORIDO JOSE CARLOS AREVALO , MARTINEZ LUIS GARCIA 
Published: June 2022

Aim: Analyze changes on body composition in obese and T2DM patients treated with semaglutide.
Methods: Observational, prospective study. Body composition was studied by bioimpedance (BIO) . Changes were evaluated over a median of 26 wk. Paired Wilcoxon test was used to analyze the differences.
Results: 54 patients (53.7% women, mean age 53.5+/-21yr) . Table 1 shows data at baseline and follow up. We found a reduction in body weigh (-3.5 kg (2.7-4.3) p=0.00) mainly related to fat mass (-6 kg (4.1-8.5) p=0.00) with a little loss of lean (-2.6 (1.3-4.1) p=0.0004) and muscle mass (-0.8 (0.0004-1.6) p=0.04) (Fig 1)
Discussion: Sarcopenic Obesity is highly prevalent in T2DM associated with comorbidities like HBP, CVD or HF. Semaglutide induces significant weight loss due to a decrease in fat mass with preservation of muscle mass.
1494-PUB: Variable Responses to GLP-1 Receptor Agonists
Authors: KUNWAR SANDEEP , SAMSON KAELI , DAVIS CLIFTON , SHIVASWAMY VIJAY , DESOUZA CYRUS 
Published: June 2022

Background: GLP1s are ineffective for a subset of patients. Differentiating between responders and non-responders based on baseline variables would allow for an individualized approach to managing diabetes.
Methods: A retrospective analysis of 324 veterans at the Omaha VA with type 2 diabetes on a GLP1 agonist to evaluate effectiveness quantified by reductions in HbA1c (&gt;/= 0.5%) body weight (&gt;/= 3%) and insulin doses (&gt;/= 10% decrease or off insulin) relative to baseline was done with the outcome being a complete response in all three. Associations between categorical variables of interest and the dichotomous outcome were assessed using Chi-Square and t-tests. A logistic regression was run for the dichotomous outcome and included variables with bivariate p-values less than 0.20.
Results: In terms of, response to one, two or all outcome variables, Dulaglutide had, 22 (38.6%) , 21 (36.8%) and 9 (15.8%) ; Liraglutide had 45 (34.6%) , 44 (33%) and 33 (25.3%) ; Semaglutide had 24 (17.5%) , 64 (46.7%) and 43 (31.4%) . Patients on Semaglutide trended towards having higher odds of a complete response (odds 2.45 95% CI 0.93, 6.48) compared to Dulaglutide. Older patients had a higher odds of a complete response (odds 1.95% CI 1.01, 1.p=0.02 Table 1) . Variables including baseline A1c, insulin dose, BMI, Metformin, and eGFR were not significantly associated with a complete response to GLP1.
Conclusion: Age and the type of GLP1 are variables that determine effectiveness.

Disclosure
S.Kunwar: None. K.Samson: None. C.Davis: None. V.Shivaswamy: Research Support; Eli Lilly and Company, Kowa Company, Ltd., Novo Nordisk. C.Desouza: Advisory Panel; AstraZeneca, Bayer AG, Novo Nordisk A/S, Consultant; Asahi Kasei Corporation.
1503-PUB: Modeling the Prediction of Improvement on Gait and Cognition among Patients Receiving Intranasal Insulin
Authors: NGO LONG H. , NOVAK VERA , NOVAK PETER , MANTZOROS CHRISTOS , DAI WEIYING , LIOUTAS VASILEIOS 
Published: June 2022

Objective: To model the probability of improvement on gait and cognition among patients who received intranasal insulin (INI)
Methods: 223 patients (1diabetes, 117 controls) randomized into 4 arms: 55 diabetes placebo, 51 diabetes INI, 59 control placebo, 58 control INI, 1women, 66±9 years of age. INI treatment lasted 24 weeks with 40 IU of INI (Novolin® R, off-label use) or placebo (sterile saline) . normal walk speed (NW) , dual task walk speed (DT) , executive function (EF) , verbal memory (VB) . Improvement due was defined to be better performance at end of treatment compared to baseline. Eleven of 20 baseline predictors were selected in a multivariable generalized linear model with logit link and binomial error to predict the probability of improvement among the 1patients who received INI.
Results: 58% of the INI patients improved on NW, 62% improved on DT, 69% EF, and 47% VB. The predictors for the final model included 6 baseline demographic variables (age, number of years of diabetes, number of years in school, Wechsler Adult Reading test, global depression score, and waist circumference; and 5 metabolism-related variables of hemoglobinA1c, fasting plasma glucose, total cholesterol, microalbumin in urine, and microalbumin to creatinine ratio.
Conclusion: Modeling technique also allows us to compute the estimated probability of improvement for any individual patients, thus, enabling us to understand better the particular demographic and metabolic profiles that best predict who among those receiving INI could benefit the most from the treatment. Funded by NIH-NIDDK (1R01DK103902) , FDA (IND#107690) , Novo Nordisk, Inc. (ISS-001063) , Medtronic Inc. (NERP15-0310) and registered on www.clinicaltrials.gov (NCT02415556.)

Disclosure
L.H.Ngo: None. V.Novak: None. P.Novak: Stock/Shareholder; Moderna, Inc., Novavax, Pfizer Inc., Prothena. C.Mantzoros: Advisory Panel; Novo Nordisk. W.Dai: None. V.Lioutas: None.

Funding
Funded by NIH-NIDDK (1R01DK103902) , FDA (IND#107690) , Novo Nordisk, Inc. (ISS-001063) , Medtronic Inc. (NERP15-0310)
1509-PUB: Effects of an Early Postpartum Lifestyle Intervention in Women with Gestational Diabetes Mellitus and Newly Diagnosed Diabetes
Authors: HU GANG , LENG JUNHONG , LIU HUIKUN , WANG LEISHEN , ZHANG SHUANG , LI WEIQIN , LI WEI , YANG XILIN , TUOMILEHTO JAAKKO 
Published: June 2022

Very few studies have assessed short-term and long-term cardiovascular effects of an early postpartum lifestyle intervention among women with gestational diabetes mellitus and diabetes. The aim of the present study was to examine whether an early postpartum 9-month intensive lifestyle intervention can lead to weight loss and improve cardiovascular risk factors among women with both GDM and newly diagnosed diabetes, and also to investigate these effects in a long term. A total of 83 women who had GDM and were newly diagnosed as type 2 diabetes at 2.6 year after delivery participated in a 9-month intensive lifestyle intervention and a follow-up survey at 6-9 years post-intervention. A total of 68 women finished the 9-month lifestyle intervention and 39 women finished the 6-9 years post-intervention survey. During the first 9-month intervention, women lost their weight at 2.76 kg (-3.81% initial weight) , decreased their waist circumference (-2.88 cm) , body fat (-1.69%) , diastolic blood pressure (-3.49 mm Hg) , fasting glucose (-0.98 mmol/L) and HbA1c (-0.71%) . During the 6-9 years post intervention, women still lost weight (-3.49 kg; -5.14% initial weight) , decreased their waist circumference (-4.03 cm) , and body fat (-1.93%) , but slightly increased their HbA1c (0.26%) , total cholesterol (0.29 mmol/L) and triglycerides (0.17 mmol/L) . The prevalence of using glucose-lowering agents increased from 2.9% at baseline to 35.3% after the 9 month lifestyle intervention, and to 48.7% at 6-9 years post-intervention. An early postpartum 9-month intensive lifestyle intervention could have effects on weight loss, decreased HbA1c and other cardiovascular risk factors among women with GDM and newly diagnosed diabetes. The weight loss effect with a lifestyle intervention can persist for at least 6 years, however, HbA1c levels slightly increased in the long term.

Disclosure
G.Hu: None. J.Leng: None. H.Liu: None. L.Wang: None. S.Zhang: None. W.Li: None. W.Li: None. X.Yang: None. J.Tuomilehto: Stock/Shareholder; Orion Pharma.

Funding
This study is supported by the grant from European Foundation for the Study of Diabetes (EFSD) /Chinese Diabetes Society (CDS) /Lilly program for Collaborative Research between China and Europe. Dr. Hu was partly supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health.
1513-PUB: HMGB1 Knockdown Increases Glucose Sensitivity, Decreases Hyperglycemia and Insulin Resistance in Type 2 Diabetes
Authors: LIU ZEYU , ALVIDREZ ROBERTO I. MOTA 
Published: June 2022

Introduction: Type-2 diabetes (T2D) characterizes by chronic hyperglycemia and insulin resistance. Hyperglycemia causes tissue damage and serious complications. High Mobility Group Box-1 (HMGB1) mediates the onset and progression of T2D, but the exact mechanism of HMGB1 glucose regulation in T2D is poorly understood. Global knockout of HMGB1 is fatal in neonatal mice primarily due to hypoglycemia. Therefore, using an inducible HMGB1 Knockout (iHMGB1 KO) model we evaluated the role of HMGB1 in adult mice progression of T2D (3) . We hypothesize that iHMGB1 KO mice will have decreased longitudinal hyperglycemia with decreased insulin resistance in a Streptozotocin (STZ) induced model of T2D.
Methods: Male 8-week adult iHMGB1 KO mice were injected with Tamoxifen IP for days (1mg/kg) to induce HMGB1 knockdown. HMGB1 Flox (wildtype) were used as control. Then, mice were injected with STZ IP for 5 days (25mg/kg) , diabetic phenotype developed for weeks. HMGB1 knockdown was characterized via immunoblot and RT-PCR. Mice were placed on normal or high fat diet to evaluate T2D progression via metabolic cage analysis (MCA) . Glucose and insulin tolerance tests (GTT and ITT) were performed.
Results: HMGB1 was significantly knocked down in iHMGB1 KO mice. MCA showed that STZ + normal diet had the appropriate respiratory quotient for translational T2D. GTT and ITT demonstrated higher glucose sensitivity and insulin tolerance in iHMGB1 KO T2D mice. Longitudinal glycemia measurement showed that iHMGB1 KO T2D mice have a progressively lower glycemia.
Conclusion: With an effective knockdown of HMGB1, we evidenced increased glucose sensitivity, decreased hyperglycemia and insulin resistance in STZ induced T2D mice. Findings show that decreasing HMGB1 allows T2D adult mice to regulate glucose metabolism and insulin sensitivity better. Further studies will be directed to investigate the mechanisms that govern the role of HMGB1 in T2D.

Disclosure
Z.Liu: None. R.I.Mota alvidrez: None.

Funding
This work was funded by department of surgery support for RIMA
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial
Authors: Heianza Yoriko , Krohn Knut , Yaskolka Meir Anat , Wang Xuan , Ziesche Stefanie , Ceglarek Uta , Blüher Matthias , Keller Maria , Kovacs Peter , Shai Iris , Qi Lu 
Published: June 2022

OBJECTIVE
To investigate whether changes in circulating levels of pancreatic islet–related miRNA-375 (miR-375) are related to improved visceral and intrahepatic fat accumulation.

RESEARCH DESIGN AND METHODS
This study included adults with abdominal obesity from an 18-month weight loss lifestyle intervention trial. Circulating miR-375-3p was measured at baseline and 18 months. MRI was performed (n = 139) to assess 18-month changes in abdominal and intrahepatic fat depots.

RESULTS
Circulating miR-375-3p was related to fasting insulin and insulin resistance in participants with prediabetes. After the interventions, there was a significant increase of miR-375-3p (P &lt; 0.001). Greater increase in miR-375-3p was associated with greater reductions of visceral (P = 0.024) and deep subcutaneous (P &lt; 0.001) adipose tissues and intrahepatic fat content (P = 0.012).

CONCLUSIONS
Increases in circulating miR-375-3p were associated with visceral and intrahepatic fat reduction. Changes in circulating pancreatic islet–related miR-375-3p may be linked to improved diabetogenic fat depots during weight loss lifestyle interventions.
Application of the Argument-Driven Inquiry Learning Model in Stimulating Students' Scientific Argumentation Skills on Acid-Base Material
Authors: Utami Siti Salsabila , Aisyah Ratna Sari Siti , Affifah Isriyanti 
Published: June 2022

Literasi sains merupakan kemampuan abad 21 yang perlu dimiliki untuk menghadapi permasalahan yang terjadi di lingkungan sekitar dan menyelesaikannya dengan konsep serta pengetahuan yang telah dimiliki. Namun masih banyak siswa yang kurang memiliki literasi sains. Rendahnya literasi sains peserta didik mengakibatkan sulitnya peserta didik dalam mengintegritaskan pengetahuan yang didapat dengan empat aspek litersi sains. Tujuan penelitian ini yaitu untuk menganalisis penerapan dan perbedaan hasil belajar sebelum dan sesudah menggunakan model pembelajaran Argument-Driven Inquiry pada materi asam basa. Pada penelitian ini menggunakan desain penelitian pre-eksperimen dengan One-Group Pretest-Postest. Sampel yang digunakan yaitu 30 orang peserta didik kelas XI IPA. Pemilihan sampel menggunakan cara Purposive Sampling. Instrument penelitian yaitu instrument tes pilihan ganda beralasan, lembar observasi dan rencana pelaksanaan pembelajaran. Teknik analisis data yang digunakan uji paired sample t-test. Hasil perhitungan uji paired sample t-test sebesar 0,000 sehingga terdapat perbedaan keterampilan argumentasi ilmiah peserta didik setelah diterapkan model pembelajaran Argument Driven Inquiry (ADI). Peserta didik lebih aktif saat pembelajaran dan memberikan argumentasi ilmiah sesuai dengan komponen argumentasi ilmiah yang baik.
A Comparison of Three Assessment Types on Student Engagement and Content Knowledge in Online Instruction
Authors: Randall Lynda , Jaynes Jessica 
Published: June 2022

The research described in this article focuses on determining the effectiveness of Bongo in promoting student retention of concepts in online learning. This study used both quantitative and qualitative measures to examine the effectiveness of student video presentation assignments on student retention of learning and perceptions of the assignment’s contributions to learning. The quantitative methods compared the effects of three treatment conditions (independent reading, Bongo video presentation, and Bongo video presentation with Auto Analysis) on retention of concepts (quizzes administered two weeks after the presentation recordings). Qualitative analysis of student perceptions of the perceived value of Bongo in general, and specifically the Auto Analysis tool, were accomplished through video surveys, transcription, and analysis. Analysis of the data provided strong support for the use of Bongo to increase student retention of concepts, and also revealed that students held favorable perceptions of the value and utility of the tool.
PENGEMBANGAN E-BOOK BERBASIS BUDAYA LOKAL SUMUT PADA MATA KULIAH PENDIDIKAN IPS KELAS TINGGI PGSD UNIMED
Authors: Nasution Yusra , Tambunan Husna P. , Risma Risma 
Published: June 2022

Penelitian ini bertujuan untuk: (1) mendeskripsikan hasil uji ahli mengenai produk E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD Unimed, dan (2) mendeskripsikan keterpakaian pengembangan E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD Unimed. Metode penelitian yang digunakan adalah model penelitian dan pengembangan (Research and Development/R&D) dengan model pengembangan Van den Akker dengan mengembangkan e-book Pendidikan IPS Kelas Tinggi Berbasis Budaya Lokal Sumut. Lokasi pelaksanaan penelitian dilakukan di prodi PGSD FIP Unimed yang terletak di Jl. Willem Iskandar / Pasar V, Medan. Populasi penelitian ini adalah seluruh mahasiswa PGSD Unimed stambuk 2020 berjumlah 225 mahasiswa yang terdiri dari 11 (A-K) kelas reguler dan ekstensi. Sampel penelitian ini dilakukan secara acara kelas dan terpilihlah satu kelas yakni kelas B Reguler 2020 yang berjumlah 40 mahasiswa. Hasil penelitian menunjukkan bahwa E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD yang dikembangkan telah divalidasi oleh ahli materi dan media. Diperoleh rata-rata skor dari ahli materi tahap I yakni 71% dengan kriteria “Layak” dan rata-rata skor ahli materi tahap II adalah 90,6 % dengan kriteria “Sangat layak”. Dan hasil penilaian ahli media 91,43% dengan kriteria “Sangat layak”. Pada uji coba produk E-book kepada mahasiswa diperoleh uji coba pre-tes dengan ketuntasan 23,07% dan hasil post-tes dengan ketuntasan 96,15%. Maka disimpulkan bahwa produk E-Book Berbasis Budaya Lokal Sumut Pada Mata Kuliah Pendidikan IPS Kelas Tinggi PGSD Unimed layak, efektif, dan praktis digunakan untuk mahasiswa PGSD Unimed stambuk 2020
Sex-related differences in the sagittal plane spinal angles in preschool and school-age children
Authors: Labecka Marta Kinga 
Published: June 2022

Abstract

Study aim: The study aimed to assess the differences in the magnitude of the anterior-posterior spinal curvatures depending on sex in children aged 5 and 9 years.

Material and methods: This prospective longitudinal observational study included 67 children (29 girls and 38 boys) in pre-school-age and school-age phases (the first examination at 5 years old and the second examination at 9 years old). Measurements of body weight and height were recorded. The computerized assessment of body posture was performed with the photo-grammetric method (MORA 4 Generation). The normality of the distribution of variables was assessed with the Shapiro-Wilk test. The Mann-Whitney U test was used to analyze the differences between the sexes in terms of body posture parameters and somatic parameters.

Results: There were no statistically significant sex-related differences in the values of parameters of the anterior-posterior spinal curvatures in 5-year-old children. In the group of 9-year-old children in the angle of lumbar lordosis, a significant difference between the sexes was found (U = 387.00, p < 0.05). Girls aged 9 had a significantly higher mean value of the angle of lumbar lordosis than boys at the same age (p < 0.05).

Conclusions: A sex-related difference was found in the magnitude of lumbar lordosis in school-age children. Understanding the gender differentiation of lumbar lordosis is the first step towards explaining the wide variability of normal lumbar lordosis in adults and the developmental and biomechanical differences between male and female lumbar spines.
Evaluating Repeatability of RTK (GPS and Galileo/GPS) performance in the analysis of points located in areas with and without obstructions
Authors: Pırtı Atınç , Yucel M. Ali 
Published: June 2022

Abstract
Galileo is Europe’s Global Navigation Satellite System (GNSS), which provides improved positioning and timing data with significant benefits for many European services and users. Galileo enables users to know their exact location with greater precision than other available systems. Access to the Galileo signal in the obstructed and unobstructed environment provides benefits and opportunities for work, thanks to the improved performance and accuracy. The use of a Galileo-enabled receiver increases the number of satellites in view significantly. When compared to the performance of single-constellation receivers, this significantly reduces the time required to obtain a position with centimetre-level accuracy. The results indicate the current Galileo constellation’s suitability for high-precision RTK applications, as well as improved availability, accuracy, reliability, and time-to-fix in the obstructed and unobstructed environments. The results of RTK GPS and RTK GPS/Galileo obtained at different times of the same day by using two reference points were compared. The results of this study illustrate that integrating RTK GPS system with Galileo is favorable for surveying applications (cm accuracy). This study shows that in surveying applications requiring centimetre accuracy, the RTK GPS/Galileo method can replace other survey methods (Total Station).
Interaksi dan Dampak Sosial Budaya dalam Pengembangan Pariwisata
Authors: Sri Widari Dewa Ayu Diyah 
Published: June 2022

This study aims to examine the social interactions between tourists and local communities and the socio-cultural impacts arising from these interactions. The method used in this research is the literature study method. This study shows that social interactions between tourists and local communities lead to positive and negative responses depending on the benefits derived from tourism development. The socio-cultural impact of tourism can be grouped into three: the effect on the demographic structure, the impact on the design and social life, and the effect on culture. To maintain tourism development at a controllable level, the monitored of the socio-cultural implications of tourism must continue to maximize its benefits of tourism. AbstrakKajian ini bertujuan untuk mengkaji tentang interaksi sosial yang terjadi antara wisatawan dan masyarakat lokal serta dampak sosial budaya yang timbul dari interaksi tersebut. Metode yang digunakan dalam penelitian ini adalah metode studi kepustakaan. Studi ini menunjukkan bahwa interaksi sosial antara wisatawan dan masyarakat lokal menimbulkan tanggapan positif dan negatif tergantung pada manfaat yang diperoleh dari pengembangan pariwisata. Dampak sosial budaya pariwisata dapat dikelompokkan menjadi tiga, yaitu dampak terhadap struktur demografi, dampak terhadap struktur dan kehidupan sosial, dan dampak terhadap budaya. Untuk menjaga perkembangan pariwisata pada tingkat yang terkendali, dampak sosial budaya pariwisata harus dipantau terus menerus untuk memaksimalkan manfaat pariwisata di destinasi.