bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preseason Prognostic Factors for Injuries and Match Loss in Collision
Sports: A Systematic Review
Authors: Watanabe Kento , Kitamura Tomoya , Takasaki Hiroshi 
Published: September 2022

AbstractThis study aimed to identify which preseason factors had strong evidence of risks
for physical injury during the season of collision sports including rugby,
American football, and Australian rules football using qualitative synthesis.
Pubmed, EMBASE, MEDLINE, SPORTDiscus, Scopus, and the Cochrane Library were
reviewed. Eligibility criteria for selecting studies were: studies involving the
collision sports; prospective cohort studies; and studies with outcomes of
relative risks, odds ratios, and correlations between players’ preseason
conditions and injury during the season. The risk of bias based on the Scottish
Intercollegiate Guidelines Network quality checklists for cohort studies was
assessed in 57 studies. The current study identified strong evidence that 1)
anthropometric characteristics (body mass index and estimated mass moment of
inertia of the body around a horizontal axis through the ankle), which are
calculated with weight and height; 2) physical function, in particular for the
trunk and lower limb (trunk-flexion hold and wall-sit hold); and 3) Oswestry
Disability Index disability, which is a patient-reported outcome measure for
disability due to low back pain, were positive prognostic factors for injury
during the collision sports season, regardless of playing experience.
Sinnhaftigkeit von ERAS-Konzepten bei kolorektalen Resektionen – eine ökonomische Analyse unter DRG-Bedingungen
Authors: Koch Franziska , Dietrich Melanie , Green Martina , Moikow Lutz , Schmidt Mareike , Ristig Matthias , Meier-Hellmann Andreas , Ritz Jörg-Peter 
Published: September 2022

Zusammenfassung
Hintergrund ERAS (Enhanced Recovery After Surgery) beschreibt ein multimodales, interdisziplinäres und interprofessionelles Behandlungskonzept, welches die postoperative
Rekonvaleszenz des Patienten durch den Einsatz evidenzbasierter Maßnahmen optimiert.
Ziel der Arbeit (Fragestellung) Ziel dieses Artikels ist es, die ökonomische Abbildbarkeit des Konzeptes im deutschen DRG-System zu untersuchen.
Material und Methoden Seit August 2019 werden Patienten in unserer Klinik nach dem später zertifizierten ERAS-Konzept behandelt. Die letzten 20 Patienten vor ERAS-Implementierung
werden im Folgenden mit 20 Patienten nach ERAS-Implementierung verglichen, die über eine Matched-Pair-Analyse identifiziert wurden. Neben dem Vergleich von Kosten und Erlös wird auch das
klinische Outcome der Patienten dargestellt.
Ergebnisse Die Fälle der Patienten der präERAS-Kohorte haben mediane Kosten von 7432,83 € verursacht. Abrechenbar waren BWR von 3,38. Der daraus resultierende DRG-Erlös für die
Patienten dieser Gruppe belief sich auf 11325,78 €. Der letztlich generierte Erlös belief sich somit auf 4575,14 €. Die Fälle der Patienten der ERAS-Kohorte haben Kosten von 5582,96 €
verursacht. Abrechenbar waren BWR in Höhe von 2,84. Der DRG-Erlös für die Patienten dieser Gruppe belief sich demnach auf 10014,18 €. Der erwirtschaftete Gewinn betrug somit 4993,84 €.
Diskussion Die durch ERAS generierte Kostenreduktion war vergleichbar zum „Verlust“ durch den BWR-Rückgang. ERAS ist demnach auch im deutschen DRG-System kostendeckend möglich.
Role of Ommaya Reservoir Placement in Hydrocephalus Management following Aneurysmal Subarachnoid Hemorrhage, an Initial Experience
Authors: Jha Vikas Chandra , Alam Shahnawaz 
Published: September 2022

Abstract
Introduction Weaning from external ventricular drainage (EVD) of cerebrospinal fluid (CSF) in hydrocephalus induced by aneurismal subarachnoid hemorrhage (SAH) had been proposed either through the rapid, gradual or intermittent approaches. There are no uniform guidelines for it. Given this, we planned to study the comparative outcome between EVD drainage with intermittent clamping versus EDV followed by Ommaya reservoir.
Material and Methods The present retrograde observational study was conducted from July 2018 to March 2021 in the department of neurosurgery with 67 patients who developed hydrocephalus following SAH after aneurysm rupture. We divided the patients into two groups. Group 1 had only EVD placed for CSF drainage with intermittent clamping before the placement of the ventriculoperitoneal (VP) shunt, and, in group 2, an Ommaya reservoir was placed after EVD before the shunt.
Result There were 38 patients in group 1 and 29 in group 2. They were age-matched, with a mild male predominance in group 1. Shunt dependency was significantly reduced in group 2 patients (p = 0.011), along with reduced length of stay in ICU (p = 0,001) and length of stay in Hospital (p = 0.019). We found improved Glasgow outcome score in group 2 patients (p = 0.006) together with reduced incidence of infarct (p = 0.0095).
Conclusion We may infer from the present study that continuous drainage through EVD, initially, in hydrocephalus induced by SAH following aneurysm rupture, increases cerebral perfusion pressure (CPP) and decreases intracranial pressure (ICP) leading to decreased infarct rate and intermittent drainage through Ommaya following EVD reservoir, decreases shunt dependency, reduces ICU and hospital stay, with improved Glasgow outcome score on follow-up, but these findings need to be validated in a prospective randomized control trial.
An Investigation of the Knowledge, Attitudes, and Practices of Physicians Regarding Child Oral Health at Primary Health Centers in Qatar: A Cross-Sectional Study
Authors: Al-Qatami Hadeel Mohammad , Al-Jaber Aisha Saleh , Abed Al Jawad Feras Hasan 
Published: September 2022

Abstract
Objectives The aim of this study was to investigate physicians' knowledge, attitudes, and practices (KAP) in relation to oral health in children attending baby well clinics in primary health care centers (PHCC) in Qatar.
Materials and Methods A cross-sectional design was adopted in which a piloted self-administered questionnaire was sent electronically to 417 physicians (pediatricians/family physicians) practicing in all PHCCs in Qatar. The questionnaire gathered information concerning demographic characteristics and KAP in relation to oral health in children. A score for each domain was given based on the percentage of correct answers.
Statistical Analysis Descriptive and analytical statistics were employed. For descriptive statistics, the frequency of distribution in relation to demographic data and responses to items of the questionnaire was presented. For analytical statistics, associations between independent variables (predictors) and KAP were assessed by employing univariate and multivariate logistic regressions. Predictors which were significantly associated in the unadjusted regression were entered into a final multivariate logistic regression to evaluate their effects after adjustment.
Results The response rate was 24%. The overall mean scores of KAP were 61, 60, and 44.4%, respectively. Females were more likely to give positive answers than males (odds ratio [OR] = 12.3, 95% confidence interval [CI] 2.4–62.2, p = 0.02). Age groups 35 to 45 and >45 years had significantly more correct answers than <35 years age group (OR= 7.5, 95% CI = 1.1–56.6 and 9.2, 95% CI 1.2–44.6, respectively, p = 0.05). No significant associations were found between any of the independent variables with attitudes. With respect to practices, multivariate logistic regression revealed that specialty was significantly associated with practices. Pediatricians were more likely to adopt positive practices when compared with family medicine physicians (OR, 95% CI = 5.3 (1–25.6), p = 0.04).
Conclusion Although physicians demonstrated moderate levels of knowledge and attitudes, this did not reflect positively on their practices. The overall score of practices was considered poor (44.4%). Poor practices in our sample reflected an urgent need for actions and plans to improve this aspect and confirmed other findings which stated that acceptable levels of knowledge or attitudes do not necessarily translate into favorable practices.
Oncocytic Meningioma: Case Report of a Rare Meningioma Variant
Authors: Casal Yuri Reis , Teixeira Lívia Porto , Bandeira Gabriela Alencar , Porceban Matheus Moreli , Paiva Wellingson Silva , Godoy Luis Filipe de Souza , Yamaki Vitor Nagai , Lucato Leandro Tavares , Alves Venâncio Avancini Ferreira , Frassetto Fernando Pereira 
Published: September 2022

AbstractOncocytic meningioma has been first identified in 1997 as a rare meningioma variant, composed predominantly of large meningothelial cells with abundant intracytoplasmic mitochondria. Here, we describe a 34-year-old male patient presenting with 2 weeks of progressive holocranial headache. Brain magnetic resonance imaging (MRI) revealed an extra axial solid-cystic expansive lesion in the left parieto-occipital parasagittal region, with intense vascularization. Histological and immunohistochemical analysis established the diagnosis. We also review briefly the pathological and radiological findings of this rare variant of meningioma as described in the literature.
Automated Detection of Poor-Quality Scintigraphic Images Using Machine Learning
Authors: Pandey Anil K. , Sharma Akshima , Sharma Param D. , Bal Chandra S. , Kumar Rakesh 
Published: September 2022

Abstract
Objective In the present study, we have used machine learning algorithm to accomplish the task of automated detection of poor-quality scintigraphic images. We have validated the accuracy of our machine learning algorithm on 99mTc-methyl diphosphonate (99mTc-MDP) bone scan images.
Materials and Methods Ninety-nine patients underwent 99mTC-MDP bone scan acquisition twice at two different acquisition speeds, one at low speed and another at double the speed of the first scan, with patient lying in the same position on the scan table. The low-speed acquisition resulted in good-quality images and the high-speed acquisition resulted in poor-quality images. The principal component analysis (PCA) of all the images was performed and the first 32 principal components (PCs) were retained as feature vectors of the image. These 32 feature vectors of each image were used for the classification of images into poor or good quality using machine learning algorithm (multivariate adaptive regression splines [MARS]). The data were split into two sets, that is, training set and test set in the ratio of 60:40. Hyperparameter tuning of the model was done in which five-fold cross-validation was performed. Receiver operator characteristic (ROC) analysis was used to select the optimal model using the largest value of area under the ROC curve. Sensitivity, specificity, and accuracy for the classification of poor- and good-quality images were taken as metrics for the performance of the algorithm.
Result Accuracy, sensitivity, and specificity of the model in classifying poor-quality and good-quality images were 93.22, 93.22, and 93.22%, respectively, for the training dataset and 86.88, 80, and 93.7%, respectively, for the test dataset.
Conclusion Machine learning algorithms can be used to classify poor- and good-quality images with good accuracy (86.88%) using 32 PCs as the feature vector and MARS as the classification model.
Reprodutibilidade do planejamento digital na artroplastia total do quadril sem cimento entre cirurgiões experientes e iniciantes
Authors: Fabricio Marcelo Zerbetto , Rudelli Bruno Alves , Miyahara Helder de Souza , Ejnisman Leandro , Gurgel Henrique de Melo Campos , Croci Alberto Tesconi 
Published: September 2022

Resumo
Objetivo Avaliar a reprodutibilidade do planejamento digital da artroplastia total de quadril (ATQ) sem cimento entre cirurgiões com diferentes níveis de experiência e o grau de confiabilidade no planejamento baseado na ATQ contralateral com o método de marcador esférico posicionado ao nível do trocanter maior.
Método Dois avaliadores com níveis de experiência diferentes (A1 e A2) realizaram de forma independente o planejamento digital operatório retrospectivo de 64 ATQs sem cimento. O planejamento foi comparado com os implantes utilizados na cirurgia, sendo classificados como: excelentes, quando idênticos; adequados, quando houve variação de uma unidade; e inadequados, quando ocorreu variação de duas ou mais unidades. Na presente análise, também foi avaliada a acurácia do parâmetro de calibragem entre a ATQ contralateral comparada com o marcador esférico ao nível do trocanter maior.
Resultados O estudo demonstrou maior êxito no planejamento quando realizado pelo avaliador mais experiente, com maior acurácia na ATQ contralateral. Ao fragmentar a análise de acordo com o parâmetro utilizado (ATQ contralateral ou marcador esférico), houve diferença estatística apenas na comparação do planejamento do avaliador A1 com os implantes utilizados na cirurgia. Esta diferença ocorreu na classificação excelente com 67,3% em ATQ contralateral como parâmetro contra 30,6% com marcador esférico (p<0,001) e inadequado de 7,1% contra 30,6%, respectivamente (p<0,001).
Conclusões A acurácia do planejamento digital é mais precisa quando realizada por um avaliador experiente e a utilização da cabeça de prótese contralateral como referência se mostrou superior à utilização de um marcador no trocanter maior.
Investigation on the Effects of Modifying Genes on the Spinal Muscular Atrophy Phenotype
Authors: Zhuri Drenushe , Gurkan Hakan , Eker Damla , Karal Yasemin , Yalcintepe Sinem , Atli Engin , Demir Selma , Atli Emine Ikbal 
Published: September 2022

Abstract
Introduction Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by the degeneration of motor neurons, muscle weakness, and atrophy that leads to infant's death. The duplication of exon 7/8 in the SMN2 gene reduces the clinical severity of disease, and it is defined as modifying effect. In this study, we aim to investigate the expression of modifying genes related to the prognosis of SMA like PLS3, PFN2, ZPR1, CORO1C, GTF2H2, NRN1, SERF1A, NCALD, NAIP, and TIA1.

Methods Seventeen patients, who came to Trakya University, Faculty of Medicine, Medical Genetics Department, with a preliminary diagnosis of SMA disease, and eight healthy controls were included in this study after multiplex ligation-dependent probe amplification analysis. Gene expression levels were determined by real-time reverse transcription polymerase chain reaction and delta–delta CT method by the isolation of RNA from peripheral blood of patients and controls.
Results SERF1A and NAIP genes compared between A group and B + C + D groups, and A group of healthy controls, showed statistically significant differences (p = 0.037, p = 0.001).
Discussion PLS3, NAIP, and NRN1 gene expressions related to SMA disease have been reported before in the literature. In our study, the expression levels of SERF1A, GTF2H2, NCALD, ZPR1, TIA1, PFN2, and CORO1C genes have been studied for the first time in SMA patients.
Bruxism as a Consequence of Stress and Movement Disorders: Brief Review
Authors: Heboyan Artak , Karobari Mohmed Isaqali , Alwadaani Abdullah Hamed , Marya Anand , Zafar Muhammad Sohail 
Published: September 2022

AbstractBruxism is considered to be an unusual repetitive movement syndrome, which is described as involuntary gnashing of teeth. The condition is classified as sleep bruxism (SB) and awake bruxism (AB). The objective of the study was to review the current literature on bruxism and its potential relation to stress and movement disorders. Factors causing bruxism are numerous. It has been found that people suffering from stress are more prone to the condition than healthy subjects. Awake bruxism is frequently observed in subjects with hyperkinetic movement disorders and it can be associated with anxiety, which involves the limbic part of the basal ganglia. However, further studies should be conducted to interpret the link more thoroughly.
Vaccination: A Literature Review from Inception till Date
Authors: Chowdhury Debanjan , Kamal Sadia 
Published: September 2022

AbstractThe history of vaccine development has seen many accomplishments, but there are still many diseases that are difficult to target, and new technologies are being brought to bear on them. Past successes have been largely due to elicitation of protective antibodies based on predictions made from the study of animal models, natural infections and seroepidemiology. Those predictions have often been correct, as indicated by the decline of many infections for which vaccines have been made over the past 200 years. However, although vaccines have undoubtedly saved many millions of lives and are heralded as one of the greatest medical inventions of all time, this is also an era of increasing vaccine hesitancy, with surveys suggesting that a large percentage of the population are unsure whether they would opt to receive a vaccine even if one becomes available for even the most virulent pandemic situation. But as age progresses, new variants of infective agents with resistance to primitive methods of immunisations have evolved. Hence, new vaccine technologies able to achieve rapid development as well as large scale production are of pivotal importance. This review emphasises on the history of vaccines, their development through ages, new technologies of vaccination, their adverse effects and homoeopathic viewpoint in the light of vaccinations.
Analysis of College of American Pathologists von Willebrand Factor Proficiency Testing Program
Authors: Salazar Eric , Long Thomas A. , Smock Kristi Johnson , Wool Geoffrey D. , Rollins-Raval Marian , Chen Dong , Harris Neil Selwyn , Chan Clarence W. , Olson John D. , Pham Huy P. , Ritter Jacob , Unold David , VanSandt Amanda Matzke , Goodwin IV Andrew Jackson 
Published: September 2022

AbstractVon Willebrand factor (VWF) level and/or function is altered in von Willebrand disease (VWD), the most common heritable bleeding disorder worldwide. Laboratory assessment of VWF is continually evolving. Historically, the primary method for the assessment of VWF platelet-binding activity was the ristocetin cofactor assay (VWF:RCo). Contemporary alternative measures of VWF platelet-binding activity include VWF:GPIbR (recombinant; using ristocetin), VWF:GPIbM (recombinant; gain-of-function mutant), and monoclonal antibody. Recently, the American Society of Hematology, International Society on Thrombosis and Haemostasis, National Hemophilia Foundation, and World Federation of Hemophilia collaboration issued guidelines recommending the use of newer assays of VWF platelet-binding activity (VWF: GPIbM, VWF: GPIbR) over VWF:RCo, given known limitations of the VWF:RCo assay. Despite this recommendation, the newer VWF:GPIbM and VWF:GPIbR assays are not United States Food and Drug Administration cleared, limiting their availability in the United States. We sought to assess assay utilization trends, agreement of VWF testing methods, and imprecision of VWF testing (based on assigned sample type) from the College of American Pathologists Proficiency Testing Surveys. The analysis confirms that, while VWF antigen testing has low imprecision, the various VWF activity assays have significant interassay variability, with VWF:RCo showing greater imprecision than the newer GPIb-binding assays. The overall trends in assay utilization reflect the barriers to complete compliance with modern VWD diagnostic guidelines in North America.
Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance
Authors: Morimont Laure , Donis Nathalie , Bouvy Céline , Mullier François , Dogné Jean-Michel , Douxfils Jonathan 
Published: September 2022

AbstractActivated protein C (APC) resistance (APCR) is considered a risk factor of venous thromboembolism (VTE). The most common genetic disorder conferring APCR is a factor (F) V Leiden mutation, but many other factors are also implicated, such as other F5 mutations (e.g., FV Hong-Kong and FV Cambridge), protein S deficiency, elevated factor VIII, exogenous hormone use, pregnancy and postpartum, depending on how APCR is defined. Considering the large population affected, the detection of this phenotype is crucial. Two types of tests are currently available: clotting time-based assays (with several versions) and thrombin generation-based assays with the endogenous thrombin potential (ETP)-based assay. The purpose of this review is therefore to discuss the performances of these tests and the cases in which it would be appropriate to use one over the other. Initially, as APCR was thought to be solely related to the FV Leiden mutation, the objective was to obtain a 100% specific assay. Clotting-time based assays were thus specifically designed to detect this inherited condition. Later on, an APCR condition without a FV Leiden mutation was identified and highlighted as an independent risk factor of VTE. Therefore, the development of a less specific assay was needed and a global coagulation test was proposed, known as the ETP-based APCR assay. In light of the above, these tests should not be used for the same purpose. Clotting time-based assays should only be recommended as a screening test for the detection of FV mutations prior to confirmation by genetic testing. On the other hand, the ETP-based APC resistance assay, in addition to being able to detect any type of APCR, could be proposed as a global screening test as it assesses the entire coagulation process.
Differential responses of
Authors: Solomonova Ekaterina , Shoman Natalia , Akimov Arkadii , Rylkova Olga 
Published: September 2022

The effect of light, copper ions, copper oxide nanoparticles on the change in the structural, functional, cytometric, fluorescent parameters of coccolithophore Pleurochrysis sp. was investigated. The culture Pleurochrysis sp. was represented by two cell forms: (1) covered with coccoliths; and (2) not covered, the ratio of which depends from growth conditions. An increase in light from 20 to 650 μE m−2 s−1 led to a decrease in the concentration of cells covered with coccoliths from 90 to 35%. With an increase in light, the decrease in the values of variable chlorophyll a fluorescence was observed, a decrease in the chlorophyll concentration was noted, and an increase in cell volumes and their granularity due to coccoliths ‘overproduction’ was recorded. A tolerance of Pleurochrysis sp. to the effect of copper was registered, both in the ionic form and in the form of a nanopowder. This is probably due to the morphological (presence of coccoliths) and physiological (ligand production) peculiarities of species. Copper did not affect the ratio of cells covered with coccoliths; its value was about 85%. Growth inhibition, a 2-fold decrease in the intracellular chlorophyll content, a decrease in Fv/Fm, and a pronounced cell coagulation were recorded at the maximum Cu2+ concentration (625 μg L−1). The mechanical effect was registered of CuO nanoparticles on the surface of Pleurochrysis sp. coccosphere, which results in the emergence of destroyed and deformed coccoliths. A hypothesis is proposed considering the protective function of coccoliths acting as a barrier when the cells are exposed to nanoparticles and copper ions.