bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfil das infecções primárias de corrente sanguínea de uma unidade de terapia intensiva neonatal
Authors: Barbosa Sara Machado Miranda Leal , Machado Josilene Ribeiro de Sousa , Melo Nayana da Silva Oliveira de , Sousa Amanda Carvalho de , Moraes Lílian Machado Vilarinho de , Silva Paula Lima da , Andrade Izane Luiza Xavier Carvalho , Alencar Larissa Nunes de , Costa Lucas Manoel Oliveira 
Published: August 2022

Objetivo: Avaliar o perfil das Infecções Primárias de Corrente Sanguínea de uma Unidade de Terapia Intensiva Neonatal. Metodo: Estudo exploratório e transversal, realizado em Unidade de Terapia Intensiva Neonatal de uma maternidade de referência no Piauí. A amostra foi constituída por todos os casos notificados de infecção primária de corrente sanguínea laboratorial e infecção primária de corrente sanguínea clínica no período de janeiro a dezembro de 2019. Resultados: Foram analisadas um total de 229 infecções relacionadas à assistência a saúde e as mais frequentes foram infecção primária de corrente sanguínea laboratorial (54,78%) e infecção primária de corrente sanguínea clínica. No início do ano de 2019, houve um aumento da densidade global (48,5) em relação à mediana de 2018 (28), que declinou ao longo do ano, chegando ao fim do mesmo com uma densidade global menor que a mediana (25,6). As principais bactérias isoladas nas hemoculturas foram Staphylococcus coagulase negativa (229) e klebisiella pneumoniae (52). Em relação ao perfil resistência, os Staphylococcus coagulase negativa apresentaram 75% de resistência para Oxacilina. Para os Staphylococcus aureus, a resistência à Oxacilina caiu para quase metade das amostras (48,1%). Nas bactérias gram-negativas, os principais agentes foram as Klebsiellas, com perfil de resistência para Piperacilina-Tazobactam de 28,3%. Conclusão: As infecções primárias de corrente sanguínea laboratorial e infecções primárias de corrente sanguínea clínica representam as principais topografias de infeções em UTI neonatal, como também o perfil microbiológico é semelhante ao perfil das infecções neonatais encontradas na literatura.
Educar para a tolerância religiosa nas escolas públicas: um desafio para o componente curricular de ensino religioso frente às tradições religiosas Afro-brasileiras
Authors: Silva Rubens Dornelas da , Rosseto Selma Correia 
Published: August 2022

O Componente Curricular de Ensino Religioso nas escolas públicas brasileiras abre possibilidades de abordar o fenômeno religioso, incluindo as diferentes expressões religiosas presentes no espaço escolar. O artigo apresenta como objetivo geral destacar que, embora o Ensino Religioso favoreça o diálogo sobre a diversidade cultural e religiosa, ainda é perceptível os desafios em publicitar algumas religiosidades, em especial, as religiões de tradição Afro-brasileiras no ambiente escolar, porém ao propor a temática para os alunos é possibilitar superações de estereótipos e de combate as reações de intolerância com intuito de garantir o direito à liberdade religiosa. A metodologia do artigo se constitui como uma revisão bibliográfica de base teórica, que norteou a reflexão sobre a importância da inclusão das tradições religiosas Afro-brasileira no ambiente escolar. Conclui-se que, o Componente Curricular de Ensino Religioso possibilita a promoção de um espaço dialógico abordando as diversas religiosidades, inclusive as religiões afro-brasileiras sem causar desconforto na comunidade escolar promovendo o respeito à liberdade religiosa das crianças e adolescentes, ocasionando aos alunos um novo olhar sobre as tradições religiosas, levando-os ao exercício da tolerância, e rompendo conceitos inautênticos advindos de longas gerações.
Evidências de omissões de cuidados de enfermagem e suas razões: revisão integrativa
Authors: Araújo Paula Roberta Silva , Rodrigues Maria Cristina Soares , Santos Anna Cecilia Soares 
Published: August 2022

Objetivo: Identificar na literatura científica os cuidados de enfermagem regularmente omitidos e as razões para essa omissão, em unidades hospitalares. Métodos: Revisão integrativa cuja pesquisa bibliográfica foi realizada nos meses de março a julho de 2022, mediante consulta a cinco bases de dados: MEDLINE, LILACS, CINAHAL ,EMBASE e SCOPUS. A pergunta de pesquisa foi elaborada com base na estratégia PICO em que o problema era “omissão de cuidado”, o fenômeno de interesse as “razões para a omissão” e o contexto o “cuidado de enfermagem”. Os critérios de inclusão foram: artigos completos relacionados ao objeto de pesquisa, sem restrição de idiomas, originados de periódicos nacionais e internacionais, indexados nas bases de dados referidas e sem limitação temporal. Resultados: Entre as produções encontradas, foram selecionados 20 artigos que passaram pelo crivo dos critérios de inclusão e exclusão, baseados na temática “cuidados de enfermagem omitidos e suas razões”. Conclusão: Evidenciou-se que os cuidados de enfermagem regularmente omitidos contribuem de modo negativo para a qualidade da assistência ofertada ao usúario de saúde e na satisfação no trabalho dos profissionais de enfermagem.
Desenvolvimento motor e social de crianças com diagnóstico de Transtorno do Espectro Autista submetidas a atividades físicas e de habilidade comunicativas
Authors: Santos Laislane Grazieli de Sousa , Marques Heloisa , Fernandes Nicolle Aragão , Rocha Vitorugo dos Santos , Wandscher Bruna , Silva Laiza Sousa da 
Published: August 2022

O Transtorno do Espectro do Autismo (TEA) é um transtorno do qual o indivíduo acometido manifesta alterações no seu desenvolvimento, dentre elas, dificuldades na comunicação e como consequência, também na interação social. A gravidade desse transtorno do neurodesenvolvimento depende do grau de autismo diagnosticado, portanto, varia em cada paciente. Posto isso, o objetivo desse estudo se dá pela busca na literatura de trabalhos que tenham utilizado intervenções de atividades físicas e de habilidades comunicativas em crianças com TEA, de modo a pontuar os aspectos positivos no desenvolvimento desses pacientes, envolvendo ganhos de habilidades motoras ou de comunicação/interação social. A consulta bibliográfica foi realizada através da busca manual nas bases de dados, Literatura Latino - Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), National Library of Medicine (PubMed/Medline) e PhysiotherapyEvidenceDatabase (PEDro). Os nove artigos incluídos na síntese qualitativa apresentaram alguma escala de medição comportamental do autismo, seja ela para avaliar as habilidades motoras ou de comunicação ou até mesmo o grau de autismo apresentado por cada criança. Para que ao final do estudo fosse feito um levantamento dos ganhos ou não ganhos, com as atividades propostas ao grupo. Constatando, portanto, que a prática de atividade física com essas crianças autistas, têm uma importante relevância na desenvoltura e manutenção de suas habilidades motoras, tal como as atividades envolvendo a comunicação. Embora diferentes intervenções tenham sido realizadas, ambas obtiveram resultados equivalentes. Podendo então afirmar que essas trazem benefícios consideráveis para indivíduos autistas.
POTENSI DAN PERMASALAHAN SEKTOR PERTANIAN DAN PETERNAKAN DI KECAMATAN GOLEWA BARAT
Authors: Bhae Christianus Ngiso , Manalu Jean Nihana , Loda Wihelmina 
Published: August 2022

Kecamatan Golewa Barat yang memiliki jumlah penduduk sebanyak 18.327 Jiwa dengan luas wilayah 94.21 Km2merupakan daerah yang masih berstatus daerah berkembang (BPS Kabupaten Ngada 2018). Status daerah berkembang yang dimiliki oleh daerah ini didukung dengan tingkat rataan nilai Indeks Pembangunan Desa (IPD) dari setiap desa yang hanya mencapai 50% sehingga masih terdapat status daerah tidak mandiri dan tertinggal (BAPPENAS 2014 dalam Kemendesa 2017). Potensi beberapa sektor yang dimiliki oleh Kecamatan Golewa Barat dapat menambah perekonomian lokal. Perekonomian lokal terdiri dari dua sektor, yaitu basis dan non-basis.Sektor basis yaitu kegiatan perekonomian dapat memasarkan barang dan jasa ke luar batas daerah perekonomian, sedangkan sektor non-basis hanya dapat menyediakan barang dan jasa untuk kebutuhan masyarakat di wilayah daerah tersebut.Kemajuan sektor basis pada suatu daerah dapat menunjang perkembangan suatu daerah (Glasson 1977 dalam Hartarto 2016).Dukungan pemerintah daerah, sektor wisata dan aspirasi masyarakat yang tumbuh dan berkembang sangat dibutuhkan dalam menciptakan pembangunan daerah yang mensejahterakan masyarakat (Kusdiana et al. 2007; Monica et al. 2017).
Electron transfer dynamics and electrocatalytic oxygen evolution activities of the Co3O4 nanoparticles attached to indium tin oxide by self-assembled monolayers
Authors: Liu Xuan , Tian Qianhong , Li Yvpei , Zhou Zixiang , Wang Jinlian , Liu Shuling , Wang Chao 
Published: August 2022

The Co3O4 nanoparticle-modified indium tin oxide-coated glass slide (ITO) electrodes are successfully prepared using dicarboxylic acid as the self-assembled monolayer through a surface esterification reaction. The ITO-SAM-Co3O4 (SAM = dicarboxylic acid) are active to electrochemically catalyze oxygen evolution reaction (OER) in acid. The most active assembly, with Co loading at 3.31 × 10−8 mol cm−2, exhibits 374 mV onset overpotential and 497 mV overpotential to reach 1 mA cm−2 OER current in 0.1 M HClO4. The electron transfer rate constant (k) is acquired using Laviron’s approach, and the results show that k is not affected by the carbon chain lengths of the SAM (up to 18 -CH2 groups) and that an increase in the average diameter of Co3O4 nanoparticles enhances the k. In addition, shorter carbon chains and smaller Co3O4 nanoparticles can increase the turn-over frequency (TOF) of Co sites toward OER. The Co3O4 nanoparticles tethered to the ITO surface show both a higher number of electrochemically active Co sites and a higher TOF of OER than the Co3O4 nanoparticles bound to ITO using Nafion.
Platelets correlate with false negative T-SPOT.TB results by inhibiting interferon-γ production in T cells via degranulation
Authors: Rao Jiayue , Rao Yuting , Guo Yang , Jiang Mei , Long Dan , Luo Qing , Huang Zikun , Li Junming 
Published: August 2022

BackgroundT-SPOT.TB (T-SPOT) is widely used for the detection of Mycobacterium tuberculosis infection by detecting interferon-gamma (IFN-γ) release in T lymphocytes. This assay is performed on peripheral blood mononuclear cells (PBMCs) separated by Ficoll density gradient centrifugation, which often contain some residual platelets. Here, we investigated the impact of platelets on T-SPOT assay and related mechanisms.MethodsThe correlation between platelet count, platelet-to-lymphocyte ratio (PLR), and the IFN-γ secreting T cells (ISCs) in positive control wells of T-SPOT assay were retrospectively analyzed. T-SPOT assay was performed with un-treated PBMCs, platelets-removed PBMCs, and platelets-enriched PBMCs to confirm the impact of platelets on T-SPOT assay. The activation of platelets and their impact on IFN-γ production in T cells were detected by flow cytometry (FCM). Platelets and T cells were cultured in a mixed culture system and co-culture system respectively, followed by detection of the frequencies of IFN-γ-producing T cells and the levels of intracellular IFN-γ in T cells by FCM. Moreover, the effect of platelet releasate on the T-SPOT assay was evaluated.ResultsThe ISCs in positive control wells of the T-SPOT assay showed a significant decrease with the increase in platelet count. The PLR of the peripheral blood were negatively correlated with the ISCs in positive control wells of the T-SPOT assay. Removal or enrichment of platelets significantly increased or decreased the ISCs and the positive rate of T-SPOT. Inhibition of platelet activation significantly increased the ISCs of T-SPOT. The frequencies of IFN-γ-producing T cells in PBMCs and the levels of intracellular IFN-γ were significantly reduced by the addition of platelets, both in the mixed culture system and the co-culture system. Platelet releasate upon thrombin activation significantly decreased the ISCs of T-SPOT.ConclusionsPlatelets correlate with negative T-SPOT results by inhibiting IFN-γ production in T cells via degranulation.
Effect of transcatheter edge-to-edge repair device position on diastolic hemodynamic parameters: An echocardiography-based simulation study
Authors: Vellguth Katharina , Barbieri Fabian , Reinthaler Markus , Kasner Mario , Landmesser Ulf , Kuehne Titus , Hennemuth Anja , Walczak Lars , Goubergrits Leonid 
Published: August 2022

BackgroundTranscatheter edge-to-edge repair (TEER) has developed from innovative technology to an established treatment strategy of mitral regurgitation (MR). The risk of iatrogenic mitral stenosis after TEER is, however, a critical factor in the conflict of interest between maximal reduction of MR and minimal impairment of left ventricular filling. We aim to investigate systematically the impact of device position on the post treatment hemodynamic outcome by involving the patient-specific segmentation of the diseased mitral valve.Materials and methodsTransesophageal echocardiographic image data of ten patients with severe MR (age: 57 ± 8 years, 20% female) were segmented and virtually treated with TEER at three positions by using a position based dynamics approach. Pre- and post-interventional patient geometries were preprocessed for computational fluid dynamics (CFD) and simulated at peak-diastole with patient-specific blood flow boundary conditions. Simulations were performed with boundary conditions mimicking rest and stress. The simulation results were compared with clinical data acquired for a cohort of 21 symptomatic MR patients (age: 79 ± 6 years, 43% female) treated with TEER.ResultsVirtual TEER reduces the mitral valve area (MVA) from 7.5 ± 1.6 to 2.6 ± 0.6 cm2. Central device positioning resulted in a 14% smaller MVA than eccentric device positions. Furthermore, residual MVA is better predictable for central than for eccentric device positions (R2 = 0.81 vs. R2 = 0.49). The MVA reduction led to significantly higher maximal diastolic velocities (pre: 0.9 ± 0.2 m/s, post: 2.0 ± 0.5 m/s) and pressure gradients (pre: 1.5 ± 0.6 mmHg, post: 16.3 ± 9 mmHg) in spite of a mean flow rate reduction by 23% due to reduced MR after the treatment. On average, velocities were 12% and pressure gradients were 25% higher with devices in central compared to lateral or medial positions.ConclusionVirtual TEER treatment combined with CFD is a promising tool for predicting individual morphometric and hemodynamic outcomes. Such a tool can potentially be used to support clinical decision making, procedure planning, and risk estimation to prevent post-procedural iatrogenic mitral stenosis.
Efficacy and safety of sacubitril/valsartan vs. valsartan in patients with acute myocardial infarction: A meta-analysis
Authors: Yang Pei , Han Yang , Lian Cheng , Wu Xinlei 
Published: August 2022

BackgroundThe angiotensin-receptor neprilysin inhibitor (ARNI) sacubitril/valsartan was shown to be superior to the angiotensin receptor blocker (ARB) valsartan in terms of reversing heart failure classification (NYHA classification), reducing N-terminal pro-brain natriuretic peptide (NT-proBNP) level and cardiovascular mortality in many studies. Yet, the efficacy of ARNI did not come from patients with acute myocardial infarction (AMI).MethodsWe searched databases for research published from inception to July 29, 2022, that reported cardiac reverse remodeling (CRR) or security indices. Two reviewers independently screened literature, extracted data, and assessed the risk of bias. Nine studies enrolling 1,369 patients were included to perform a meta-analysis. There were 716 patients in the ARNI group and 653 in the ARB group.ResultsARNI outperformed ARBs in terms of CRR indices, with striking changes in left ventricular ejection fraction (EF) (MD: 4.12%, 95%CI: 2.36, 5.88, P &lt; 0.0001), diameter (MD: –3.40 mm, 95%CI: –4.30, –2.94, P &lt; 0.00001, I2 = 0%) and left atrial diameter (MD: –2.41 mm, 95%CI: –3.85, –0.97, P = 0.001, I2 = 0%), other indices there showed no significant improvements. The incidences of major adverse cardiac events (RR: 0.47, 95%CI: 0.34–0.65, P &lt; 0.00001, I2 = 0%), the heart failure (RR: 0.37, 95%CI: 0.23–0.61, P &lt; 0.0001, I2 = 0%), readmission (RR: 0.54, 95%CI: 0.36–0.80, P = 0.003, I2 = 29%) in the sacubitril/valsartan group were lower than the ARB group, while the incidences of cardiac death (RR: 0.56, 95%CI: 0.28, 1.09, P = 0.09), the myocardial infarction (RR: 0.83, 95% CI: 0.39, 1.77, P = 0.63), adverse side effects (RR: 1.67, 95% CI: 0.89, 3.13, P = 0.11) showed no difference.ConclusionThis research indicated that early initiation of sacubitril/valsartan in patients after AMI was superior to ARBs in reducing the risks of major adverse cardiac events, heart failure, readmission, and enhancing left ventricular EF, decreasing diameter, left atrial diameter. As for the other outcomes (the incidences of cardiac death, myocardial infarction, and adverse side effects), sacubitril/valsartan demonstrated no obvious advantage over ARBs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier [CRD42022307237].
Development of a Model Predicting the Outcome of In Vitro Fertilization Cycles by a Robust Decision Tree Method
Authors: Fu Kaiyou , Li Yanrui , Lv Houyi , Wu Wei , Song Jianyuan , Xu Jian 
Published: August 2022

IntroductionInfertility is a worldwide problem. To evaluate the outcome of in vitro fertilization (IVF) treatment for infertility, many indicators need to be considered and the relation among indicators need to be studied.ObjectivesTo construct an IVF predicting model by a robust decision tree method and find important factors and their interrelation.MethodsIVF and intracytoplasmic sperm injection (ICSI) cycles between January 2010 and December 2020 in a women’s hospital were collected. Comprehensive evaluation and examination of patients, specific therapy strategy and the outcome of treatment were recorded. Variables were selected through the significance of 1-way analysis between the clinical pregnant group and the nonpregnant group and then were discretized. Then, gradient boosting decision tree (GBDT) was used to construct the model to compute the score for predicting the rate of clinical pregnancy.ResultThirty-eight variables with significant difference were selected for binning and thirty of them in which the pregnancy rate varied in different categories were chosen to construct the model. The final score computed by model predicted the clinical pregnancy rate well with the Area Under Curve (AUC) value achieving 0.704 and the consistency reaching 98.1%. Number of two-pronuclear embryo (2PN), age of women, AMH level, number of oocytes retrieved and endometrial thickness were important factors related to IVF outcome. Moreover, some interrelations among factors were found from model, which may assist clinicians in making decisions.ConclusionThis study constructed a model predicting the outcome of IVF cycles through a robust decision tree method and achieved satisfactory prediction performance. Important factors related to IVF outcome and some interrelations among factors were found.
Type 1 diabetes-related autoimmune antibodies in women with gestational diabetes mellitus and the long-term risk for glucose intolerance
Authors: Beunen Kaat , Vercauter Lies , Van Crombrugge Paul , Moyson Carolien , Verhaeghe Johan , Vandeginste Sofie , Verlaenen Hilde , Vercammen Chris , Maes Toon , Dufraimont Els , Roggen Nele , De Block Christophe , Jacquemyn Yves , Mekahli Farah , De Clippel Katrien , Van Den Bruel Annick , Loccufier Anne , Laenen Annouschka , Devlieger Roland , Mathieu Chantal , Benhalima Katrien 
Published: August 2022

AimsTo characterize women with gestational diabetes mellitus (GDM) positive for type 1 diabetes-related autoimmune antibodies (T1D-related autoantibodies) in pregnancy and to evaluate their risk for long-term glucose intolerance.MethodsIn a multi-centric prospective cohort study with 1843 women receiving universal screening for GDM with a 75 g oral glucose tolerance test (OGTT), autoantibodies were measured in women with GDM: insulin autoantibodies (IAA), islet cell antibodies (ICA), insulinoma-associated protein-2 antibodies (IA-2A) and glutamic acid decarboxylase antibodies (GADA). Long-term follow-up ( ± 4.6 years after delivery) with a 75 g OGTT and re-measurement of autoantibodies was done in women with a history of GDM and autoantibody positivity in pregnancy.ResultsOf all women with GDM (231), 80.5% (186) received autoantibody measurement at a mean of 26.2 weeks in pregnancy, of which 8.1% (15) had one positive antibody (seven with IAA, two with ICA, four with IA-2A and two with GADA). Characteristics in pregnancy were similar but compared to women without autoantibodies, women with autoantibodies had more often gestational hypertension [33.3% (5) vs. 1.7% (3), p&lt;0.001] and more often neonatal hypoglycemia [40.0% (6) vs. 12.5% (19), p=0.012]. Among 14 of the 15 autoantibody positive women with an early postpartum OGTT, two had impaired fasting glucose (IFG). Of the 12 women with long-term follow-up data, four tested again positive for T1D-related autoantibodies (three positive for IA-2A and one positive for ICA and IAA). Five women were glucose intolerant at the long-term follow-up of which two had IA-2A (one had IFG and one had T1D) and three without autoantibodies. There were no significant differences in long-term characteristics between women with and without autoantibodies postpartum.ConclusionsSystematic screening for T1D-related autoantibodies in GDM does not seem warranted since the low positivity rate for autoantibodies in pregnancy and postpartum. At 4.6 years postpartum, five out of 12 women were glucose intolerant but only two still had autoantibodies. In women with clinically significant increased autoantibody levels during pregnancy, postpartum autoantibody re-measurement seems useful since the high risk for further increase of autoantibody levels.
Pubertal timing in children with Silver Russell syndrome compared to those born small for gestational age
Authors: Patti Giuseppa , Malerba Federica , Calevo Maria Grazia , Schiavone Maurizio , Scaglione Marco , Casalini Emilio , Russo Silvia , Fava Daniela , Bassi Marta , Napoli Flavia , Allegri Anna Elsa Maria , D’Annunzio Giuseppe , Gastaldi Roberto , Maghnie Mohamad , Di Iorgi Natascia 
Published: August 2022

ContextData on pubertal timing in Silver Russell syndrome (SRS) are limited.Design and methodsRetrospective observational study including twenty-three SRS patients [11p15 loss of methylation, (11p15 LOM, n=10) and maternal uniparental disomy of chromosome 7 (mUPD7, n=13)] and 21 small for gestational age (SGA). Clinical (thelarche in females; testis volume ≥ 4 ml in males; pubarche), BMI SD trend from the age of 5 to 9 years to the time of puberty, biochemical parameters of puberty onset [Luteinizing hormone (LH), 17-β-estradiol, testosterone], and bone age progression were evaluatedResultsPubertal onset and pubarche occurred significantly earlier in children with SRS than in SGA (p 0.03 and p 0.001, respectively) and clinical signs of puberty onset occurred earlier in mUPD7 than in 11p15LOM group (p 0.003). Five SRS children experienced central precocious puberty and LH, 17-β-estradiol, testosterone were detected earlier in SRS than in SGA (p 0.01; p 0.0001). Bone age delay in SRS children was followed by rapid advancement; the delta between bone age and chronological age in SRS group became significantly higher than in SGA group at the age of 9-11 years (p 0.007). 11p15LOM patients were underweight at the age of 5 years and showed a progressive normalization of BMI that was significantly higher than in mUPD7 (p 0.04) and SGA groups (p 0.03) at puberty onset.ConclusionTiming of puberty is affected in SRS and occurred earlier in mUPD7 compared to 11p15LOM. The impact of early puberty on adult height and metabolic status deserves long-term evaluation.