bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical or Non-Surgical Treatment of Plantar Fasciopathy (SOFT). Study protocol for a randomized controlled trial
Authors: Møller Stefan , Riel Henrik , Wester Jens , Jensen Carsten , Simony Ane , Viberg Bjarke 
Published: June 2022

Abstract
Background: Plantar fasciopathy is the most common reason for complaints of plantar heel pain and one of the most prevalent musculoskeletal conditions with a reported lifetime incidence of 10%. The condition is normally considered self-limiting with persistent symptoms that often last for several months or years. Multiple treatments are available, but no single treatment appears superior to the others. Heavy-slow resistance training and radiofrequency microtenotomy for the treatment of plantar fasciopathy has shown potentially positive effects on short- and long-term outcomes (> 3 months). However, the effect of heavy-slow resistance training compared with a radiofrequency microtenotomy treatment is currently unknown. This trial compares the efficacy of heavy-slow resistance training and radiofrequency microtenotomy treatment with supplemental standardised patient education and heel-inserts in improving the Foot Health Status Questionnaire pain score after 6 months in patients with plantar fasciopathy.Methods: In this randomized superiority trial, we will recruit 70 patients with ultrasound-confirmed plantar fasciopathy and randomly allocate them to one of two groups: (1) Heavy-slow resistance training, patient education and a heel-insert (n = 35); (2) Radiofrequency microtenotomy treatment, patient education and a heel-insert (n = 35). All participants will be followed for 1 year, with the 6-month follow-up considered the primary endpoint. The primary outcome is the Foot Health Status Questionnaire pain domain score. Secondary outcomes include the remaining three domains of the Foot Health Status Questionnaire, a Global Perceived Effect scale, the physical activity level, and Patient Acceptable Symptom State, which is the point at which participants feel no further need for treatment.Discussion: By comparing the two treatment options, we should be able to answer if radiofrequency microtenotomy compared with heavy-slow resistance training is superior in patients with plantar fasciopathy.Trial registration: ClinicalTrials.gov Identifier: NCT03854682. Prospectively registered on February 26, 2019
Denoising Data in Signal Processing under the Complex Fuzzy Environment
Authors: Khan Madad , Rehman Raja Fida Ur , Anis Saima , Zeeshan Muhammad 
Published: June 2022

Abstract
In this paper, we have established some new operations and results of set theory for complex fuzzy sets (CFSs). Moreover, we introduced the basic results of complex fuzzy sets with their examples such as complex fuzzy union, complex fuzzy intersection, complex fuzzy complement, complex fuzzy Cartesian product, complex fuzzy bounded sum, complex fuzzy bounded difference, complex fuzzy algebraic sum, and complex fuzzy algebraic product. We established a new algorithm for the application of a complex fuzzy set in denoising data. We employed CFSs in data denoising using Fast Fourier transform since the phase term of CFS is periodic and performs like a Fast Fourier transform. We introduced a novel methodology for exploiting a CFS to develop a new model of the matrix, in which we identified a reference signal and removed noise from a specific signal.
Physical Layer Security Transmission Method Based on Artificial Noise in Full-Duplex User-Aided Cooperative SWIPT NOMA System
Authors: Jin Yong , Liu Chuang , Guo Ruijie , Zhou Lin , Hu Zhentao 
Published: June 2022

Abstract
We deeply explore the physical layer security of simultaneous wireless information and power transfer (SWIPT) network which uses the cooperative non-orthogonal multiple access (NOMA) technique in this paper. A novel cooperative NOMA strategy in which the near user with full-duplex ability is employed as a friendly relay by using SWIPT technology to harvest energy is proposed to enhance the capability of user far from base station (BS). Moreover, artificial-noise (AN) cooperation scheme is also proposed to improve the physical layer security while minimizing the base station transmitting power. To tackle nonconvex problem related to above cooperative NOMA strategy, we present a semidefinite-relaxation (SDR) and successive convex approximation (SCA) scheme. Numerical simulation results show that compared with other schemes, our scheme can significantly reduce the transmit power required by BS and improve the physical layer security of network.
Post-viral fatigue following SARS-CoV-2 infection during pregnancy: a longitudinal comparative study
Authors: Oliveira Ana Maria da Silva Sousa , Carvalho Mariana Azevedo , Nacul Luis , Cabar Fabio Roberto , Fabri Amanda Wictky , Peres Stela Verzinhasse , Zaccara Tatiana Assuncao , O'Boyle Shennae , Alexander Neal , Takiutu Nilton Hideto , Mayaud Philippe , Brizot Maria de Lourdes , Francisco Rossana Pulcineli Vieira 
Published: June 2022

Abstract
Background: Several studies have reported post-COVID-19 fatigue in the general population, but none explored post-COVID-19 fatigue among pregnant women. The objectives of this study were to determine the prevalence over time, duration and risk factors of post-viral fatigue among pregnant women infected with SARS-CoV-2. Methods: Longitudinal comparative study involving 588 pregnant women with SARS-CoV-2 investigation during pregnancy or at delivery in Sao Paulo, Brazil. Three groups were investigated: G1 (N=259) women with COVID-19 (symptomatic SARS-CoV-2 infection) identified during pregnancy; G2 (N=131) women with positive SARS-CoV-2 serology determined at delivery; G3 (N=198) women with negative SARS-CoV-2 serology at delivery. Questionnaires investigating fatigue were applied at 6 weeks, 3 and 6 months after SARS-CoV-2 identification for G1; and at delivery, 6 weeks, 3 and 6 months after delivery for all groups. The prevalence of fatigue, fatigue most of the time, and significant fatigue were determined at all timepoints. Cox regression analysis was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) to evaluate the risk of remaining with fatigue over time in G1 women.Results: Prevalence of overall fatigue in G1 women at 6 weeks, 3 and 6 months were 40.6%, 33.6% and 27.8%, respectively. The cumulative risk of remaining with fatigue increased over time according to the severity of disease, with HR of 1.69 (95%CI: 0.89-3.20) and 2.43 (95%CI: 1.49-3.95) for women with moderate and severe symptoms, respectively. In multivariate analysis, the independent risk factors of fatigue in G1 women were cough and myalgia. At and after delivery the prevalence of fatigue was significantly higher in G1 women compared to G2 and G3 women at all time points. Conclusions: The prevalence of post-viral fatigue is higher in pregnant women acquiring SARS-CoV-2 during pregnancy, and the risk and duration of fatigue increase with severity of infection.
Sudden gamer death: non-violent death cases linked to playing video games
Authors: Kuperczko Diana , Kenyeres Peter , Darnai Gergely , Kovacs Norbert , Janszky Jozsef 
Published: June 2022

Abstract
Background and aims: Internet gaming disorder (IGD) is an emerging problem. Rarely, media reports about people, who have died during playing video games, but thus far no systematic, scientific study is available about the topic. We investigated such cases, looking for common characteristics, connection between gaming and death, and the possible reasons leading to death.Methods: Cases were collected through internet search with general keywords, with ones specific to identified cases, and by working along cross references.Results: 24 cases were found: one from 1982, the others between 2002 and 2021. Twenty-three of the victims were male, age ranged from 11 to 40 years. More than half of the cases originated from Southeast Asia, and 12 deaths happened in internet cafes. Gamers played action-rich multiplayer games. In 18 cases the gaming session before death was extremely long (around a day or even several days) with minimal rest. The cause of death was pulmonary embolism in 5 cases, cerebral hemorrhage in 2 cases, most of the rest was presumably due to fatal cardiac arrhythmia.Discussion: Long sedentary position and dehydration may precipitate thromboembolism, acute blood pressure elevation during gaming may promote cerebral hemorrhage, and several factors (including acute and chronic sleep deprivation, exhaustion, stress) can lead to acute autonomic dysfunction and fatal arrhythmia. Conclusion: Incidence of non-violent death cases linked to playing video games is presumably very low. It mostly occurs in young males and it is often characterized by extremely long gaming time.
The applicability of Linehan Risk Assessment Scale: A cross-sectional study from Alexandria Poison Centre, Egypt during the COVID-19 pandemic
Authors: Fouad Hoda , Badreldine Fatma , Kerim Ahmed Abd El , Hieba Rim , Kholeif Wael 
Published: June 2022

Abstract
Purpose: Suicide is a critical health problem that is significantly rising during the COVID-19 pandemic worldwide, yet it is still under-reported in Egypt. To date, a deficiency of a reliable scale to probe the risk factors underlying suicide liability among patients with deliberate self-poisoning. The study's objective was to offer a snapshot of the pattern of self- poisoning in Egypt during the COVID-19 pandemic. Methods: Using the Linehan risk assessment and management protocol LRAMP, a psychological assessment was applied to evaluate vulnerable patients needing urgent psychiatric support and emphasize the influence of previous suicidal behaviors. A cross-sectional study was conducted on all patients admitted to Alexandria Poison Centre with deliberate self-poisoning Biosocial and poisoning data were recorded in a specially designed sheet. All patients were interviewed for underlying risk factors and protective factors for suicidal behavior. Results: Significant relation was recorded between previous suicidal attempts and psychiatric diseases. CNS depressant drugs and rodenticides recorded the highest frequency. The calculated score (suicide and protective factors) was higher in patients with previous suicidal attempts. Conclusion: The study was the first to test the applicability of Linehan scale in Alexandria Poison Centre. The results are promising however, multicenter replication of the concluded findings will be valuable.
Anti-inflammatory potential of Baicalein combined with silk fibroin protein in a Zebrafish model (Danio rerio)
Authors: Holanda Fabrício H , Ribeiro Arlef N , Sánchez-Ortiz Brenda L , de Souza Gisele C , Borges Swanny F , Ferreira Adriana M , Florentino Alexandro C , Yoshioka Sérgio A , de Moraes Lienne S , Carvalho José Carlos T , Ferreira Irlon 
Published: June 2022

Abstract
Baicalein (BA) is a flavonoid with wide-ranging pharmacological activity. However, its biological evaluation is hampered by its low solubility in aqueous medium, making forms of incorporation that improve its solubility necessary. In the present study, BA was combined with a solution of silk fibroin protein (SF), a biomaterial used as a drug carrier, to evaluate the anti-inflammatory potential of this combination, in vivo, in an experimental model, zebrafish (Danio rerio). Baicalein-Silk fibroin (BASF) improved the DPPH (2,2‐diphenyl‐1‐picryl‐hydrazyl‐hydrate) free radical scavenging rate (95%) in comparison with BA in solution. The acute toxicity study and histopathological analysis in zebrafish showed that BASF showed low cytotoxic potential up to a dose of 2.000 mg/kg. The use of BA in combination with SF enhanced the anti-inflammatory effect of flavonoids by inducing inflammatory peritoneal edema through carrageenan and achieved 77,6% inhibition of abdominal edema at a dose of 75 mg/kg. The results showed that the BASF, significantly increases the bioavailability and therapeutic effect of flavonoids and several results observed in this study may help in the development of new drugs.
Economic and racial disparities of the weather impact on air quality in Brazil
Authors: Requia Weeberb J. , Castelhano Francisco Jablinski 
Published: June 2022

Abstract
Several studies have quantified the air pollution exposure disparities across racial and income groups. There is still a lack of investigations assessing disparities related to the impacts of weather on air pollution, which could indicate target air pollution reduction strategies under different climate scenarios. Our study aims to address this gap by estimating the economic and racial disparities of the weather impact on air quality in Brazil between 2003 and 2018. This study was divided into two stages. First, we used a generalized additive approach to fit two models to estimate the daily concentration of PM2.5 in each municipality in Brazil. We fitted a model adjusted for weather variables and an unadjusted model (without weather variables). Both models were controlled for temporal terms. This framework derived “weather penalty” by accounting for the differences in the β values among the adjusted and unadjusted models (βunadjusted - βadjusted). A positive penalty (βunadjusted > βadjusted) suggests that an increase in PM2.5 was associated with long-term weather changes between 2003 and 2018. In the second state, we estimated the population-weighted weather penalty for two groups in Brazil - racial and income. We found that the average penalty for the white population was 8.1% higher than that of the black population in Brazil. In the stratification analysis by region, the results were the same in the North, Northeast, and Southeast regions, in which white was the most-exposed group. In contrast, the Midwest and South were the regions where the black population was the most-exposed group, with a percentage difference in the average penalty of 2.4 and 3.7% that of the white population, respectively. For the income group, our results indicate that the high-income population group (income > third quartile of the income distribution) was the most-exposed group in all analyses, including the national and the regional analyses.
Therapeutic Potential of Nutritional Food for Healthy Cardiovascular System-Molecular Mechanism
Authors: VERMA RAVINDRA , Bisen Prakash S 
Published: June 2022

Abstract
Objective
Nutritional therapy, integrative and functional medicine, and psychiatry are areas of medicine where there has been limited research on the cause of disease and nutritional therapy. Modern medicine treats the medical cause, not the symptoms. All medicines are toxic in some way. Now, healthcare professionals are recommending food as medicine.
Methods
For this review, an extensive search was performed in electronic databases and in scientific publications. Boolean search methods were used in search engines such as Google Scholar, PubMed, Mendley, and other scientific databases. Search engines use terms such as food, metabolic disorder, cardio-vascular disorder, food and/or functional food, etc. We reviewed the latest findings on food and metabolic disorders, especially those related to cardiovascular disease.
Results
Scientific research suggests that fruit and vegetables in a regular diet will reduce the risk of coronary heart disease and heart failure. Nature provides a large number of dietary options in the appropriate combination that can improve our health and cure metabolic disorders. It has been shown that a vegetarian diet and a Mediterranean diet have significant impact on the gut microbiome and cardiovascular disease risk.
Conclusions
A healthy lifestyle with a proper diet is essential in addition to traditional drug treatment for improving the lipid profile of cardiac patients. To develop effective targeted therapies, we need to further study molecular and cellular mechanisms of CVD. Genetic, inflammatory, nutritional, and immune factors can be studied to determine the pathogenesis of cardiometabolic syndrome.
Influence of ILM peeling on macular blood flow in patients with diabetic epiretinal membrane
Authors: Li Bo , Gou Wenjun , You Hui , Bai Mengtian , Xie Chen , Li Heng 
Published: June 2022

Abstract
Background
To study the effect of intraoperative internal limiting membrane(ILM)peeling on the macular vascular structure in patients with diabetic epiretinal membrane (ERM).
Methods
Patients with diabetic ERM were divided into an ERM + ILM peeling group (18 eyes) and an ERM peeling group (19 eyes), all of whom underwent standard vitrectomy and were followed up until 6 months postoperatively. Best-corrected visual acuity(BCVA), Central macular thickness (CMT), Vessel density (VD) and vessel length density (VLD) of the superficial as well as deep retinal capillary plexus were compared between the two groups.
Results
There was no significant difference in BCVA (P > 0.05) and CMT (P > 0.05) between the two groups. In the superficial capillary plexus (SCP), the change in VD (p = 0.106) and VLD (p = 0.438) was not affected by peeling the ILM, and there was no significant difference in VD (p = 0.162) and VLD (p = 0.391) between the two groups at month 6. For the deep capillary plexus (DCP), there was an effect of ILM peeling on the changes in VD (p = 0.024) and VLD (p = 0.012); peeling of the ILM delayed the recovery time of the VD and VLD, and the VD (p = 0.003) and VLD (p = 0.000)in the ERM + ILM peeling group at postoperative month 6 were lower than those in the ERM peeling group.
Conclusion
Intraoperative peeling of the ILM in patients with diabetic ERM delayed the improvement of blood flow signal in the DCP but did not affect the recovery of postoperative BCVA and CMT.
Identification of soil properties influencing DRIS indices of maize in the savannas of northern Nigeria
Authors: Aliyu Kamaluddin Tijjani , Kamara Alpha Y. , Huising Jeroen , Adam Adam M. , Shehu Bello M. , Jibrin Jibrin M. 
Published: June 2022

Abstract
AimsImproper nutrient management reduces yield and affects the nutrient status of crops. This study aimed at diagnosing nutrient limitation in maize.MethodsA three-year multi-location (348 sites) nutrient experiments were conducted in randomized blocked design to analyse nutrient limitations for maize production under conventional fertilizer recommendation system in Nigeria using DRIS and to identify soil factors that influence DRIS indices using random forest model. DRIS indices for nutrients were calculated from the results of ear leaf samples collected from the experimental plots. The DRIS indices were summed, and used to cluster the plots using k-means cluster algorithmResultsResults show large differences in average yield between the clusters. The clusters also differed based on frequency to which nutrients are most limiting. B was the most limiting in cluster one and three, Mn in cluster two and K in cluster four. Random forest results show that soil pH, B and Mg had the largest influence on DRIS indices in cluster one. DRIS indices were most influenced by soil N and B in cluster two. To lesser extent, soil contents of Fe, K, Mg and S also influenced DRIS indices in cluster two. Soil K, B and Zn were the most significant factors that influenced DRIS indices in cluster four. Bulk Density, Fe, Na, ECEC, and organic carbon had a moderate influence on the indices in this cluster.ConclusionsNutrient limitation in plants can be diagnose using DRIS method. Soil properties have a definite influence on maize nutrient status.
The efficacy of Intrathecal Methyl-Prednisolone for acute Spinal cord injury: a prospective double-blinded randomized clinical trial
Authors: Sarpoolaki Mohammad Kazem , Meshkini Ali , Iranmehr Arad , Mirzaei Farhad , Badripour Abolfazl , Rafiei Ebrahim , Vafaei Ali , Khalilzadeh Morteza , Fattahi Mohammad reza 
Published: June 2022

Abstract
Study design: randomized clinical trialObjectives: evaluate the safety and effectiveness of intrathecal Methyl-Prednisolone compared to intravenous Methyl-Prednisolone in acute spinal cord injuriesSetting: Imam Reza Hospital, Tabriz University of Medical SciencesMethods: patients meeting our inclusion and exclusion criteria were enrolled in the study and divided randomly into two treatment arms: intrathecal and intravenous. Standard spinal cord injury care (including surgery) was given to each patient based on our institutional policy. Patients were then assessed for neurological status (based on ASIA scores, Frankel scores) and complications for six months and compared to baseline status after injury. To better understand the biological bases of methylprednisolone on SCI, we measured two biomarkers for oxidative stress (serum malondialdehyde and total antioxidant capacity) in these patients at arrival and day three after injury.Results: The present study showed no significant difference between the treatment arms in neurological status (sensory scores or motor scores) or complications. However, the within-group analysis showed improvement in neurological status in each treatment arm within six months. Serum malondialdehyde and total antioxidant capacity were analyzed, and no significant difference between the groups was seen.Conclusion: This is the first known clinical trial investigating the effect of Methyl-Prednisolone in acute SCI patients. We have shown that there might be a role in using MP in young patients with acute SCI. Further studies should be conducted to define the positive and negative effects of this somehow novel technique in different populations as well.
Discovery, Synthesis and in silico approach of pyrrolo [3,4-c]pyrroles as SARS-CoV-2 M pro inhibitors
Authors: Mani Kailasam Saravana , Rajamanikandan S. , Prabha Balakrishnan 
Published: June 2022

Abstract
A new series of pyrrolo [3,2-c] pyrroles were synthesized and characterized using various analytical techniques including FT-IR, UV-Vis and NMR spectroscopic studies. The biological descriptors of the synthesized compounds were investigated using DFT calculation. The mode of binding and reactivity of the target compounds with SARS-CoV-2 main protease (Mpro) were studied using molecular docking and molecular dynamics (MD) simulation. Molecular docking of the compounds (4a and 5a) showed a promising binding affinity towards Mpro protein with the binding energy of -8.3 kcal/mol and − 8.0 kcal/mol, respectively. The results of MD simulation and prime MM-GBSA calculation were consistent with molecular docking. The absorption, distribution, metabolism, excretion (ADME) properties of the compounds are in the acceptable range, as they are orally active and obey Lipinski’s rule of five without violation. In addition, in silico toxicity prediction using the Pro-Tox II revealed the non-toxic nature of the compounds. Hence the obtained results suggest that these compounds could be a possible anti-viral candidate and highlight this series of compounds for further drug design and development against SARS-CoV-2.
Abrasive Waterjet Turning 3D Jet Deflection Analysis and Process Accuracy Prediction for Al 2024 Alloy
Authors: Kilinc Hande Esra , Annoni Massimiliano 
Published: June 2022

Abstract
The jet deflection phenomenon is one of the main causes for the larger workpiece final diameter respect to the ideal target diameter in Abrasive Waterjet Turning (AWJT). Hence, the predetermination of the final workpiece diameter necessitates measuring the jet deflection. The aim of the present work is to develop a novel on-line measurement methodology of the 3D deflection of the jet in AWJT by the contemporary use of two cameras and a dedicated image processing routine. The selected variable machining process parameters were feed rate (Vf), depth of cut (DOC) and the rotational direction of the workpiece. An empirical model was developed for predicting the workpiece final diameter accuracy on Al 2024 alloy based on the jet deflection and including the effect of the jet divergence. The obtained results form the base for a new type of AWJT modelling, on-line monitoring and closed-loop control and could be a first step to make the DOC a handier process parameter, as it happens in standard turning.