bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas Terapi Non-Farmakologis Terhadap Nyeri Tindakan Invasif Pada Neonatus Di Rumah Sakit Umum Daerah dr. Zainoel Abidin
Authors: X Sri Intan Rahayuningsih , X Rosni , X Ramlah , X Nova Fajri 
Published: March 2022

Prosedur tindakan invasif merupakan salah satu prosedur yang sering dilakukan di rumah sakit khususnya di ruang NICU dan menimbulkan nyeri pada neonatus. Beberapa manajemen nyeri non-farmakologi untuk menurunkan nyeri adalah dengan pemberian pacifier, ASI, dan bedung. Namun metode tersebut masih perlu diukur keefektifannya dalam manajemen menurunkan nyeri. Tujuan dari penelitian ini adalah untuk mengidentifikasi efektivitas terapi non-farmakologis terhadap nyeri tindakan invasif pada neonatus di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda (RSUDZA) Aceh. Penelitian ini menggunakan desain randomized control trial (RCT). Populasi dalam penelitian ini adalah seluruh neonatus risiko tinggi yang tidak mendapatkan obat sedasi di ruang NICU level IIA dan IIB RSUDZA. Jumlah sampel sebanyak 19 orang dan menggunakan teknik randomisasi alokasi yang terdiri dari empat kelompok yaitu kelompok kontrol, kelompok intervensi 1 (pemberian pacifier), kelompok intervensi 2 (pemberian pacifier dan bedung), dan kelompok intervensi 3 (pemberian ASI dan bedung). Skala nyeri pada sampel dinilai menggunakan intrumen neonatal infant pain scale (NIPS). Analisis statistik menggunakan uji normalitas, uji homogenitas, uji anova dan uji Post Hoc Bonferroni. Hasil penelitian ini menunjukkan bahwa data normal, homogen dan diperoleh p valu e0,364 yang berarti tidak ada perbedaan tingkat nyeri antar semua kelompok penelitian. Namun secara klinis, kelompok intervensi pemberian pacifier dan bedung memiliki skala nyeri terendah (2,25) dan memiliki perbedaan rerata 2,6 poin dengan kelompok kontrol. Diharapkan seluruh perawat di NICU dapat melakukan pengkajian nyeri pada neonatus terutama saat tindakan invasif agar dapat memberikan manajemen nyeri yang tepat.
Attitudes of Child Life Specialists Towards Telehealth
Authors: Bacon Kathryn , Mallavarapu Suma 
Published: March 2022

Objective: Telehealth is the use of virtual platforms to facilitate interactions between patients and medical providers, and its use has increased in recent years and especially during the COVID-19 pandemic. Studying attitudes of medical providers towards telehealth is an important first step to effectively providing services virtually. Previous researchers have explored the attitudes of physicians towards telehealth, but none have surveyed Certified Child Life Specialists (CCLSs). CCLSs provide coping strategies and support for children in medical settings (e.g., hospitals and rehab centers). The main goal of this study was to explore the attitudes of CCLSs in the hospital setting towards telehealth and how they have implemented it during the pandemic. Method: Using an online survey, researchers collected data from 63 CCLSs to better understand the use and perceived effectiveness of telehealth. Results: Data collected indicates that participants agree telehealth has substantial benefits for both patients and providers. Conclusion: The findings from this study highlight the attitudes of CCLs towards telehealth and give us a better understanding of these services which are critical to children and their families. Disclosure Statement: No potential conflict of interest was reported by the author(s). Funding Statement: No funding sources were provided by the author(s).
Persepsi Masyarakat Desa Katumbangan terhadap Riba dalam Praktek Utang Piutang
Authors: Athifah Idnan Tsabitha Aidin  , Nasrul  
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui bagaimana presepsi masyarakat Desa Katumbangan terhadap riba dalam melakukan praktek utang piutang. Jenis penelitian ini menggunakan penelitian kualitatif deskriptif, responden dalam penelitian ini adalah masyarakat Desa Katumbangan. Teknik pengumpulan data dilakukan dengan obeservasi, wawancara, dan dokumentasi. Hasil penelitian ini didapatkan bahwa presepsi masyarakat Desa Katumbangan akan riba masih sangat rendah sebab, masyaraakat hanya mengetahui riba tapi tidak memahami betul. Dalam melaksanakan praktek utang piutang mereka sudah merasa sudah benar dengan alasan untuk kepentingan tolong menolong sesama masyarakat dan mencari keuntungan dari hasil gabah yang menjadi bunga yang menjadi kultur secara turun temurun dengan perjanjian kedua bela pihak atas dasar suka sama suka dan pihak peminjam uang merasa terbantu untuk memenuhi kebutuhan ekonomi yang sifatnya terdesak.
Pemahaman Masyarakat dalam Mengeluarkan Zakat Perdagangan; Studi pada Desa Balangtanayya Kab. Takalar
Authors: Risnawati  , St.Fauziah Anwar  
Published: March 2022

Tujuan dari penelitian ini ingi mengetahuai seberapa luas pemahaman masyarakat Desa Balangtanayya tentang pembayaran zakat . Metode yang digunakan dalam penelitian adalah pendekatan kualitatif, dengan studi kasus deskriptif. Penelitian kualitatif adalah suatu penelitianyang ditunjukkan untuk mendeskripsikan, dan menganalisis fenomena, pengumpulan data dilakukan dengan menggunakan wawancara , observasi langsung ke lapangan, dan analisis dari bahan-bahan tertulis dari sumber data utama. Hasil dari penelitian adalah masyarakat desa balangtanayya hanya beberapa saja yang mengetahui atau memahami tentang pengeluaran dari zakat perdagangan, mereka lebih mengenal zakat fitrah saja yang dimana dikeluarkan tiap tahunnya, ada juga bebrapa orang yang mengetahui tantang pengeluaran zakat perdagangan tetapi mereka tidak mengetahui bahwa zakat tersebut disaluurkan kemana karena didesa balangtanayya tidak terdapat tempat atau wadah untuk menyalurkan zakat tersebut.
CD30+ Lymphoproliferative Disorders as Potential Candidates for CD30-Targeted Therapies
Authors: Schwarting Roland , Behling Eric , Allen Ashleigh , Arguello-Guerra Vivian , Budak-Alpdogan Tulin 
Published: March 2022

Context.—In the early 1980s, a monoclonal antibody termed Ki-1 was developed against a cell line derived from a patient with Hodgkin lymphoma. This antibody detected a limited number of benign activated lymphocytes in lymphoid tissue, whereas in Hodgkin lymphoma it appeared to be nearly specific for Reed-Sternberg cells and their mononuclear variants. Subsequent studies showed that Ki-1 expression defined a new type of lymphoma that was later designated anaplastic large cell lymphoma with or without anaplastic large cell kinase expression/translocation. In the past 30 years, numerous new lymphoma entities have been defined, many of which are variably positive for CD30. Many virally transformed lymphoproliferative disorders are also frequently positive for CD30.Objective.—To illustrate the broad spectrum of CD30+ hematologic malignancies and to provide an update of CD30-targeted therapies.Data Sources.—Personal experiences and published works in PubMed.Conclusions.—Because of its low expression in normal tissue, CD30 was studied as a therapeutic target for many years. However, the first functional humanized antibody against CD30 was developed only about 10 years ago. Brentuximab vedotin is a humanized anti-CD30 antibody linked to a cytotoxin, and was approved by the US Food and Drug Administration in 2012 for treating refractory Hodgkin lymphoma and anaplastic large cell lymphoma. Since then, the list of Food and Drug Administration–approved CD30-targeted hematologic malignancies has grown. Recently, the therapies using tumor antigen-specific chimeric antigen receptor T cells targeting CD30 have incited a great deal of enthusiasm and are studied in clinical trials.
Design and Test of Marine Engine Safety Management Model Based on “Reverse Management”
Authors: Yingchun Xue , Guoping Chen 
Published: March 2022

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The main purpose of this study is to improve the level of marine safety management. The safety checklist and reverse management model are used to check and measure marine safety. The results indicate that the test results are M1 = 88.705 and M2 = 95.164 respectively (M2 &gt; M1), suggesting that the reverse management safety model has played a positive role in the actual operation. It has been concluded the reverse management model can improve the safety level of marine engineering management, but not all factors are significantly improved. This paper summarizes the working principle of reverse management, which is feasible in practical application.

Introduction
In recent years, fishing vessel accidents occur frequently in China (Jiangqun 2008; Huadang 2011; Yuanjiao 2015). For example, there are nearly 20,000 fishing boats in Liaoning Province. Most of them are equipped with a four-wheel hydraulic winder favored by the majority of fishermen for its advantages of large pulling force and fast net pulling speed. However, there are also serious safety risks, such as finger breaking in light cases and arm breaking in heavy cases (Dage et al. 2004). Most of the wooden fishing boats above 60 hp in Hebei Province have purchased four-wheel winders and eliminated the original two-wheel ones. Through actual case, it has played a role in increasing work efficiency and improving economic benefits. However, we can also see that the number of casualties of fishing boat crew has increased significantly. According to preliminary statistics, there were more than 120 net gear accidents in 2000 in the whole province, seriously injuring more than 30 crew members, which seriously affected the fishery safety situation (Qiang 2002). These situations are closely related to ship automation.
Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study
Authors: Howe Laurence J , Brumpton Ben , Rasheed Humaira , Åsvold Bjørn Olav , Davey Smith George , Davies Neil M 
Published: March 2022

Background:Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships are potentially causal. However, population MR studies are sensitive to demography (population stratification, assortative mating) and familial (indirect genetic) effects.Methods:In this study, we performed within-sibship MR analyses using 78,988 siblings, a design robust against demography and indirect genetic effects of parents. For comparison, we also applied population MR and estimated associations with measured height.Results:Within-sibship MR estimated that 1 SD taller height lowers the odds of coronary heart disease by 14% (95% CI: 3–23%) but increases the odds of cancer by 18% (95% CI: 3–34%), highly consistent with population MR and height-disease association estimates. There was some evidence that taller height reduces systolic blood pressure and low-density lipoprotein cholesterol, which may mediate some of the protective effects of taller height on coronary heart disease risk.Conclusions:For the first time, we have demonstrated that the purported effects of height on adulthood disease risk are unlikely to be explained by demographic or familial factors, and so likely reflect an individual-level causal effect. Disentangling the mechanisms via which height affects disease risk may improve the understanding of the etiologies of atherosclerosis and carcinogenesis.Funding:This project was conducted by researchers at the MRC Integrative Epidemiology Unit (MC_UU_00011/1) and also supported by a Norwegian Research Council Grant number 295989.
The mRNA and miRNA profiles of goat bronchial epithelial cells stimulated by Pasteurella multocida strains of serotype A and D
Authors: An Qi , Chen Si , Zhang Luyin , Zhang Zhenxing , Cheng Yiwen , Wu Haotian , Liu Ang , Chen Zhen , Li Bin , Chen Jie , Zheng Yiying , Man Churiga , Wang Fengyang , Chen Qiaoling , Du Li 
Published: March 2022

Pasteurella multocida (P. multocida) is a zoonotic bacterium that predominantly colonizes the respiratory tract and lungs of a variety of farmed and wild animals, and causes severe respiratory disease. To investigate the characteristics of the host immune response induced by P. multocida strains of serotype A and D, high-throughput mRNA-Seq and miRNA-Seq were performed to analyze the changes in goat bronchial epithelial cells stimulated by these two serotypes of P. multocida for 4 h. Quantitative RT-PCR was used to validate the randomly selected genes and miRNAs. The results revealed 204 and 117 differentially expressed mRNAs (|log2(Fold-change)| ≥ 1, p-value < 0.05) in the P. multocida serotype A and D stimulated groups, respectively. Meanwhile, the number of differentially expressed miRNAs (|log2(Fold-change)| > 0.1, p-value < 0.05) were 269 and 290, respectively. GO and KEGG enrichment analyses revealed 13 GO terms (p-value < 0.05) and four KEGG pathways (p-value < 0.05) associated with immunity. In the serotype A-stimulated group, the immune-related pathways were the GABAergic synapse and Toll-like receptor signaling pathways, while in the serotype D-stimulated group, the immune-related pathways were the phagosome and B cell receptor signaling pathways. Based on the predicted results of TargetScan and miRanda, the differentially expressed mRNA–miRNA network of immune-related GO terms and KEGG pathways was constructed. According to the cell morphological changes and the significant immune-related KEGG pathways, it was speculated that the P. multocida serotype D strain-stimulated goat bronchial epithelial cells may induce a cellular immune response earlier than serotype A-stimulated cells. Our study provides valuable insight into the host immune response mechanism induced by P. multocida strains of serotype A and D.
Two new glassfrogs (Centrolenidae:Hyalinobatrachium) from Ecuador, with comments on the endangered biodiversity of the Andes
Authors: Guayasamin Juan M. , Brunner Rebecca M. , Valencia-Aguilar Anyelet , Franco-Mena Daniela , Ringler Eva , Medina Armijos Anderson , Morochz Carlos , Bustamante Lucas , Maynard Ross J. , Culebras Jaime 
Published: March 2022

BackgroundThe Tropical Andes is the world’s most biodiverse hotspot. This region contains >1,000 amphibian species, more than half of which are endemic. Herein we describe two new glassfrog species (Centrolenidae:Hyalinobatrachium) that we discovered within relatively unexplored and isolated localities of the Ecuadorian Andes.MethodsWe employed morphological, acoustic, and molecular methods to test the hypothesis thatHyalinobatrachium mashpisp. nov andH. nounssp. nov. are species new to science. Following standard methods, we generated mitochondrial sequences (16S) of 37 individuals in the genusHyalinobatrachium. We inferred the phylogenetic relationships of the two new species in comparison to all other glassfrogs using Maximum Likelihood. In addition to describing the call ofH. mashpisp. nov., we performed a discriminant analysis of principal components (DAPC) with the advertisement call characteristics of several congeners.ResultsBased on an integrative taxonomy approach, we describe two new species. Morphological traits and the inferred phylogeny unambiguously place the new taxa in the genusHyalinobatrachium. Both species are distinguished from other glassfrogs mainly by their dorsal coloration (i.e., dorsum lime green with small light yellow spots, head usually with interorbital bar) and transparent pericardium (i.e., the heart is visible through the ventral skin). The new species exhibit a high morphological similarity (i.e., cryptic) and occur within relatively close geographical proximity (closest aerial distance = 18.9 km); however, their uncorrectedpdistance for the mitochondrial gene 16S is 4.6–4.7%, a value that greatly exceeds the genetic distance between closely related species of centrolenid frogs. The DAPC revealed that the advertisement call ofH. mashpisp. nov. is acoustically distinct.DiscussionOur findings are congruent with several previous studies that report a high degree of endemism in the Toisán mountain range, which appears to be isolated from the main Andean cordillera for some amphibian groups. We recommend that bothH. mashpisp. nov. andH. nounssp. nov. be listed as Endangered, following IUCN criteria. These new species provide another example of cryptic diversity in the Andes—further evidence that the region fosters much more biodiversity than we have the resources to catalog. Threatened by mining and other exploitative industries, these glassfrogs and many other yet-to-be-discovered Andean species highlight the dire need for effective conservation measures—especially in northwestern Ecuador.
Metabolic adjustment and regulation of gene expression are essential for increased resistance to severe water deficit and resilience post-stress in soybean
Authors: Alves da Silva Adinan , Oliveira Silva Cíntia , do Rosario Rosa Vanessa , Silva Santos Michel Filiphy , Naomi Kuki Kacilda , Dal-Bianco Maximiller , Delmond Bueno Rafael , Alves de Oliveira Juraci , Santos Brito Danielle , Costa Alan Carlos , Ribeiro Cleberson 
Published: March 2022

Background
Soybean is the main oilseed crop grown in the world; however, drought stress affects its growth and physiology, reducing its yield. The objective of this study was to characterize the physiological, metabolic, and genetic aspects that determine differential resistance to water deficit in soybean genotypes.

Methods
Three soybean genotypes were used in this study, two lineages (L11644 and L13241), and one cultivar (EMBRAPA 48-C48). Plants were grown in pots containing 8 kg of a mixture of soil and sand (2:1) in a greenhouse under sunlight. Soil moisture in the pots was maintained at field capacity until the plants reached the stage of development V4 (third fully expanded leaf). At this time, plants were subjected to three water treatments: Well-Watered (WW) (plants kept under daily irrigation); Water Deficit (WD) (withholding irrigation until plants reached the leaf water potential at predawn of −1.5 ± 0.2 MPa); Rewatered (RW) (plants rehydrated for three days after reached the water deficit). The WW and WD water treatments were evaluated on the eighth day for genotypes L11644 and C48, and on the tenth day for L13241, after interruption of irrigation. For the three genotypes, the treatment RW was evaluated after three days of resumption of irrigation. Physiological, metabolic and gene expression analyses were performed.

Results
Water deficit inhibited growth and gas exchange in all genotypes. The accumulation of osmolytes and the concentrations of chlorophylls and abscisic acid (ABA) were higher in L13241 under stress. The metabolic adjustment of lineages in response to WD occurred in order to accumulate amino acids, carbohydrates, and polyamines in leaves. The expression of genes involved in drought resistance responses was more strongly induced in L13241. In general, rehydration provided recovery of plants to similar conditions of control treatment. Although the C48 and L11644 genotypes have shown some tolerance and resilience responses to severe water deficit, greater efficiency was observed in the L13241 genotype through adjustments in morphological, physiological, genetic and metabolic characteristics that are combined in the same plant. This study contributes to the advancement in the knowledge about the resistance to drought in cultivated plants and provides bases for the genetic improvement of the soybean culture.
Selective Hydrogenation of Naphthalene to Decalin Over Surface‐Engineered α‐MoC Based on Synergy between Pd Doping and Mo Vacancy Generation
Authors: Ma Yufei , Liu Jianbin , Chen Meng , Yang Qun , Chen Hedong , Guan Guoqing , Qin Yanlin , Wang Tiejun 
Published: March 2022

AbstractAlthough the hydrogenation of aromatics is important for the processing of fossil fuels and biofuels, it typically requires costly (e.g., noble metal‐based) catalysts and exhibits unsatisfactory selectivity. Herein, flake‐like nanocrystalline molybdenum carbide (α‐MoC) is surface‐engineered via Pd doping, and the synergy between the in‐situ generated Mo vacancies and doped Pd species is shown to promote the selective hydrogenation of naphthalene to decalin. Experimental and theoretical evidence reveal that this enhanced performance is due to the optimization of naphthalene adsorption energy and the establishment of a unique surface structure due to (i) surface environment modulation, (ii) the adjustment of electron density around Mo atoms, and (iii) the change in the strength of Mo‐H bonding caused by d‐band center optimization. Benefiting from the unique surface structure, the obtained optimum 0.5% Pd‐α‐MoC catalyst exhibits excellent performance. The developed strategy is successfully used to fabricate other noble metal (Pt, Ru)‐doped α‐MoC catalysts, thus holding promise as a universal method for the rational design of high‐performance metal carbide‐based hydrogenation catalysts.
Novel Concept of Separator Design: Efficient Ions Transport Modulator Enabled by Dual‐Interface Engineering Toward Ultra‐Stable Zn Metal Anodes
Authors: Liang Yongchang , Ma Dingtao , Zhao Ning , Wang Yanyi , Yang Ming , Ruan Jianbin , Yang Guanghui , Mi Hongwei , He Chuanxin , Zhang Peixin 
Published: March 2022

AbstractSluggish transport kinetics and rapid dendrite growth are considered the main obstacles that impair the performance of Zn metal batteries. This work has developed a unique strategy of dual‐interface engineering (DIE) to design the separator as efficient ions transport modulator. The dual function of spontaneous polarization effect and high zincophilicity of BaTiO3 (BTO) is revealed by combining the theoretical and experimental studies. Benefiting from the decoration of BTO on glass fiber and well filling of the surface interspace, the DIE‐modified separator can not only effectively capture and accelerate Zn2+ transport between the fiber–electrolyte interface, but also redistribute the ions transport into homogenization in the separator–anode interface. Therefore, the modified Zn anodes perform highly reversible Zn plating/stripping with ultrahigh cumulative capacity even up to 9500 mAh cm−2 at the high current density of 10 mA cm−2. Meanwhile, the modified Zn‐MnO2 battery can retain a specific capacity of 108 mAh g−1 after 1800 cycles at 1 A g−1. Furthermore, the capacity retention of the battery also can be improved from 37.5% up to 115% at 0.2 A g−1 after 100 cycles. Such a novel concept for separator engineering provides a new perspective to enable ultra‐stable Zn metal anodes and high‐performance Zn metal batteries.
H‐Dimeric Nanospheres of Amphipathic Squaraine Dye with an 81.2% Photothermal Conversion Efficiency for Photothermal Therapy
Authors: Wang Yigang , Xia Guomin , Tan Manman , Wang Mingda , Li Yingzhong , Wang Hongming 
Published: March 2022

AbstractUnderstanding and implementing the ordered supramolecular assembly in organic photothermal materials is challenging, yet significant, for photothermal performance enhancement. Herein, an amphipathic squaraine dye (PSQ) with a poly (ethylene glycol) chain attached as a hydrophilic anchor is synthesized. In aqueous solution, PSQ spontaneously self‐assembles into uniform nanospheres (PSQ‐NSs) with well‐defined H‐dimeric substructures. Molecular dynamics simulations are conducted to illustrate the self‐assembly process. Reorganization energy calculations show that nonradiative decay is accelerated by H‐dimeric PSQ low‐frequency out‐of‐plane vibrational modes, which enables a rapid dissipation of excited‐state energy to heat. As such, the resultant H‐dimeric PSQ‐NSs exhibit ultrahigh photothermal conversion efficiency (81.2%) under laser irradiation (0.3 W cm−2, 808 nm) in water. In vitro and in vivo evaluations confirm their high stability, biocompatibility, tumor accumulation, and efficient tumor inhibition in photothermal therapy. It is expected that the self‐assembling H‐dimers will become a unique platform for the precise designing of small‐molecule PTAs for future clinical PTT applications.