bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antigen–Antibody Interaction‐Derived Bioadhesion of Bacterial Cellulose Nanofibers to Promote Topical Wound Healing
Authors: Kim Seulgi , Ko Jina , Choi Jae Hyuk , Kang Jeong Yi , Lim Chanoong , Shin Mikyung , Lee Dong Woog , Kim Jin Woong 
Published: January 2022

AbstractA practically helpful bioadhesion system can be developed for biomedical treatments by taking advantage of the antigen–antibody interaction in which an antibody binds to a protein with specific lock and key binding affinity. This study presents a new type of skin tissue adhesive system in which an involucrin antibody (SY5)‐conjugated bacterial cellulose nanofiber (BCNF) is bound to involucrin (IVL) in corneocytes of the stratum corneum. For this, the SY5 is covalently incorporated on the surface of carboxylate of 2,2,6,6‐tetramethylpiperidine‐1‐oxyl radical (TEMPO)‐oxidized BCNFs via the 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide (EDC)/N‐hydroxysuccinimide (NHS) coupling reaction. It is shown that the SY5‐conjugated BCNF (BCNFSY5) exhibits the antigen–antibody interaction with the IVL, eventually leading to effective adhesion to the skin surface. Moreover, it is demonstrated that the BCNF‐based skin adhesion promotes wound healing by basically providing a tissue environment where cell proliferation can occur actively. These results emphasize that the BCNFSY5 system could pave the way for developing a new type of tissue adhesive for skin tissue regeneration.
Microenvironments Enabled by Covalent Organic Framework Linkages for Modulating Active Metal Species in Photocatalytic CO2 Reduction
Authors: Yang Shuailong , Sa Rongjian , Zhong Hong , Lv Haowei , Yuan Daqiang , Wang Ruihu 
Published: January 2022

AbstractCovalent organic frameworks (COFs) are promising platforms for understanding photocatalytic CO2 reduction processes owing to their predesignable structures and tailor‐made functions. Herein, a nickel‐modified COF composed of N‐acylhydrazone‐linked electron‐donor and electron‐acceptor dyads (H‐COF‐Ni) is reported. H‐COF‐Ni generates 5694 µmol g−1 of CO with 96% selectivity over H2 evolution in 2 h under visible light irradiation, which greatly outperforms that of typical imine‐linked counterpart. Experimental and theoretical results have demonstrated that metal active sites in host frameworks are deprived by 2,2′‐bipyridine additive to form new catalytic active species, the separation and transfer process of the photogenerated charge carriers are not main reason for their activity difference. The linkage‐dependent activation of CO2 molecules on Ni centers is responsible for high photocatalytic efficiency. This study provides new protocols to improve CO2 photoreduction performance through the modification of linkage microenvironments.
Toward Excellence of Electrocatalyst Design by Emerging Descriptor‐Oriented Machine Learning
Authors: Liu Jianwen , Luo Wenzhi , Wang Lei , Zhang Jiujun , Fu Xian‐Zhu , Luo Jing‐Li 
Published: January 2022

AbstractMachine learning (ML) is emerging as a powerful tool for identifying quantitative structure–activity relationships to accelerate electrocatalyst design by learning from historic data without explicit programming. The algorithms, data/database, and descriptors are usually the decisive factors for ML and the descriptors play a pivotal role for electrocatalysis as they contain the essence of catalysis from the physicochemical nature. Despite the considerable research efforts regarding electrocatalyst design with ML, the lack of universal selection tactics for descriptors bridging the gap between structures and activity impedes its wider application. A timely summary of the application of ML in electrocatalyst design helps to deepen the understanding of the nature of descriptors and improve the application scope and design efficiency. This review summarizes the geometrical, electronic, and activity descriptors used as input for ML training and predicting to reveal the general rules for their application in the design of electrocatalysts. In response to the challenges of hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, CO2 reduction reaction, and nitrogen reduction reaction, the ML application in these areas is tracked for the progress and prospective changes. Additionally, the potential application of the automated design and discovery are discussed for the other well‐known electrocatalytic processes.
Highly Regulatable Heat Conductance of Graphene–Sericin Hybrid for Responsive Textiles
Authors: Liang Xiaoping , Fan Aoran , Li Zhen , Wei Ning , Fan Wei , Liang Huarun , Wang Haomin , Bi Peng , Li Shuo , Wu Xun‐En , Lu Haojie , Hao Qing , Zhang Xing , Zhang Yingying 
Published: January 2022

AbstractAdvanced heat‐managing textiles not only improve the comfort of individual but also reduce the energy consumption of the heat‐managing systems of building. To meet the demand of heat‐managing in a dynamic environment, responsive textiles with tunable thermal convection and radiation have been developed, while the design of fabrics with tunable thermal conduction remains unexplored. Here, a humidity‐driven and flexible thermal conductance regulating material is developed that shows an unprecedented switching ratio up to 14×, which is composed of brick‐and‐mortar structured graphene and silk sericin (GS). This work investigates the microstructure variation in response to humidity experimentally and theoretically. The regulation can be ascribed to the hydration/dehydration of sericin and the subsequent changing in graphene–sericin interfacial thermal conductance. It is demonstrated that the GS can be facilely coated on ordinary textiles through dyeing to achieve responsive thermal‐managing clothes with a significant and reversible response toward the variation of environment humidity.
Super‐Hybrid Transition Metal Sulfide Nanoarrays of Co3S4 Nanosheet/P‐Doped WS2 Nanosheet/Co9S8 Nanoparticle with Pt‐Like Activities for Robust All‐pH Hydrogen Evolution
Authors: Wang Haiqing , Xu Jinhao , Zhang Qiubo , Hu Shuxian , Zhou Weijia , Liu Hong , Wang Xun 
Published: January 2022

AbstractHighly active and multifunctional non‐precious metal‐based hydrogen evolution reaction (HER) eletcrocatalysts have aroused great interest in the large‐scale conversion of sustainable electrical energy to fuels and feedstocks in different application scenarios. Here, a metal sulfide‐based super hybrid nanoarray composed of a metallic Co3S4 nanosheet, P doped WS2 nanosheet, and Co9S8 nanoparticles (Super‐Co3S4/P‐WS2/Co9S8) for all‐pH HER is reported. The Super‐Co3S4/P‐WS2/Co9S8 only requires 58, 70, and 129 mV in alkaline, acid, and neutral media, respectively, to reach 10 mA cm‐2, which also presents fast reaction kinetics and high long‐term stability. The experimental and density functional theory (DFT) results verify that the abundant active heterostructure in Super‐Co3S4/P‐WS2/Co9S8 can not only provide Pt‐like H*‐adsorption Gibbs free energy (ΔGH*) but also promote the H2O adsorption and dissociation kinetics for all‐pH HER. Moreover, the collaboration of favorable metallic components and special nanoarray morphology can also strengthen the electric conductivity for electron transfer and promote the maximum exposure of active heterointerfaces for mass transport in electrocatalysis. The interesting strategy herein is expected to inspire the future design of advanced metal sulfide‐based heterostructures for energy storage and conversion.
Transforming Passive into Active: Multimodal Pheophytin‐Based Carbon Dots Customize Protein Corona to Target Metastatic Breast Cancer
Authors: Peng Yayun , Cong Yiyang , Lei Yuzhu , Sun Fanwen , Xu Menghan , Zhang Jingzi , Fang Lei , Hong Hao , Cai Ting 
Published: January 2022

AbstractFormation of protein corona on nanomaterials surface in vivo is usually considered as an unpredictable event for a predefined targeted delivery system for malignant cancers. In most situations, these protein coronas substantially change targeting efficiency or even cause adverse reactions which both hinder the clinical translation of the cargo‐delivery systems. Active customization of protein corona onto nanomaterials surfaces can benefit their biomedical performances and open up new opportunities in construction of targeted delivery systems. Herein, lipid‐PEG/pheophytin carbon dots (LPCDs) are prepared from natural chlorophyll and integrate seamlessly with positron emission tomography imaging, near‐infrared fluorescence imaging, and photodynamic therapy capacity. In vitro measurements demonstrate that the LPCDs can actively absorb apolipoproteins into the protein corona to enhance their uptakes in breast cancer cells. In vivo studies confirm that LPCDs can give accurate delineation of metastatic breast cancer foci from surrounding normal tissues with multimodal biomedical functions. The feasibility of using LPCDs as a multimodal imaging and cancer‐targeting nanoplatform may provide impetus for developing precise yet facile protein corona‐targeted delivery systems for future clinical practice.
Crosslinked Protein Delivery Strategy with Precise Activity Regulation Properties for Cancer Therapy and Gene Editing
Authors: Liu Ning , Zhu Lianghan , Sun Honghao , Zhou Zhanwei , Dong Jingwen , Sun Minjie 
Published: January 2022

AbstractProtein drugs hold tremendous promise for therapeutic applications due to their direct and superior pharmacological effects. However, protein drugs can be degraded in blood stream and unable to cross many physical barriers to exert therapeutic effect. Degradable synthetic crosslinking is a versatile strategy to enhance the stability of the nanoparticle in a complex physiological medium and is helpful to get through physical barriers. Herein, crosslinked polypeptide (PABP) composed of poly‐amino acids including cystine, tyrosine, lysine, ketal bridge, and polyethylene glycol (PEG) is modularly explored and synthesized for protein delivery. Notably, plasma membrane V‐ATPase is the particular pathway which induces the macropinocytosis of the inner peptide analogous core (PAB/protein) after the outer PEG shell disassociation at tumor intercellular sites. In addition, PABP/protein achieves proteins’ activity shielding in systemic circulation and recovery in tumor cytoplasm precisely. In application, PABP/RNase‐A shows satisfying tumor accumulation and antineoplastic efficacy. More importantly, PABP/Cas9 + small guide RNA displays obvious gene editing efficiency. The crosslinked protein delivery strategy not only makes the accurate protein transport and activity regulation possible but also is promising in paving the way for clinical translation of protein drugs.
A Water‐Soluble Organic Photocatalyst Discovered for Highly Efficient Additive‐Free Visible‐Light‐Driven Grafting of Polymers from Proteins at Ambient and Aqueous Environments
Authors: Lee Yungyeong , Kwon Yonghwan , Kim Youngmu , Yu Changhoon , Feng Siyang , Park Jeehun , Doh Junsang , Wannemacher Reinhold , Koo Byungjin , Gierschner Johannes , Kwon Min Sang 
Published: January 2022

AbstractSince the pioneering discovery of a protein bound to poly(ethylene glycol), the utility of protein–polymer conjugates (PPCs) is rapidly expanding to currently emerging applications. Photoinduced energy/electron‐transfer reversible addition–fragmentation chain‐transfer (PET‐RAFT) polymerization is a very promising method to prepare structurally well‐defined PPCs, as it eliminates high‐cost and time‐consuming deoxygenation processes due to its oxygen tolerance. However, the oxygen‐tolerance behavior of PET‐RAFT polymerization is not well‐investigated in aqueous environments, and thereby the preparation of PPCs using PET‐RAFT polymerization needs a substantial amount of sacrificial reducing agents or inert‐gas purging processes. Herein a novel water‐soluble and biocompatible organic photocatalyst (PC) is reported, which enables visible‐light‐driven additive‐free “grafting‐from” polymerizations of a protein in ambient and aqueous environments. Interestingly, the developed PC shows unconventional “oxygen‐acceleration” behavior for a variety of acrylic and acrylamide monomers in aqueous conditions without any additives, which are apparently distinct from previously reported systems. With such a PC, “grafting‐from” polymerizations are successfully performed from protein in ambient buffer conditions under green light‐emitting diode (LED) irradiation, which result in various PPCs that have neutral, anionic, cationic, and zwitterionic polyacrylates, and polyacrylamides. It is believed that this PC will be widely employed for a variety of photocatalysis processes in aqueous environments, including the living cell system.
Interplay between Charge Injection, Electron Transport, and Quantum Efficiency in Ambipolar Trilayer Organic Light‐Emitting Transistors
Authors: Moschetto Salvatore , Benvenuti Emilia , Usta Hakan , Ozdemir Resul , Facchetti Antonio , Muccini Michele , Prosa Mario , Toffanin Stefano 
Published: January 2022

AbstractThe fascinating characteristic of organic light‐emitting transistors (OLETs) of being electrical switches with an intrinsic light‐emitting capability makes them attractive candidates for a wide variety of applications, ranging from sensors to displays. To date, the OLET ambipolar trilayer heterostructure is the most developed architecture for maximizing device performance. However, a major challenge of trilayer OLETs remains the inverse correlation between external quantum efficiency and brightness under ambipolar conditions. The complex interconnection between electroluminescent and ambipolar charge transport properties, in conjunction with the limited availability of electron transport semiconducting materials, has indeed hampered the disruptive evolution of the OLET technology. Here, an in‐depth study of the interplay of the key fundamental features that determine the device performance is reported by exploring electron transport semiconductors with different properties in ambipolar trilayer OLETs. Through the selection of compounds with tailored chemical structures, the relation between intrinsic optoelectronic characteristics of the electron transport semiconductor, energy level alignment within the structure, and morphological features is unraveled. Furthermore, the introduction of a suitable electron injector at the emissive/semiconducting layers interface sheds light into the bidimensional nature of OLETs that is a distinguishing factor of this class of devices with respect to prototypical organic light‐emitting diodes.
Ytterbium‐Enriched Outmost Shell for Enhanced Upconversion Single Molecule Imaging and Interfacial Triplet Energy Transfer
Authors: Hu Jialing , Guan Daoming , Zhao Bingjie , Zhang Yanxin , Qiu Xiaochen , Zhang Yunxiang , Liu Qian 
Published: January 2022

AbstractLanthanide‐based upconversion single molecule imaging (u‐SMI) is of great interest due to its excellent photostability and background‐free detection. However, the dim brightness strongly hampers its application in quantitative studies. An inert shell can effectively enhance the upconversion brightness, especially for highly doped upconversion nanocrystals in which surface quenching is the dominant nonirradiative pathway. Here, it is discovered that inert shell is actually a drawback for u‐SMI in a volume‐constrained system and sensitizer Yb3+ doped outmost shell outperforms inert shell in single molecule imaging condition, which indicates that the number of Yb3+ sensitizers is the fundamental bottleneck for u‐SMI and the surface quenching can be noncritical. The effect of Yb3+‐enriched shell on the interfacial energy transfer‐based dye‐sensitized upconversion is also investigated and orders of magnitude enhancement is obtained over the previously reported design.
Confining Carboxylized Carbon Nanotube for Phosphorescence Afterglow with Optical Memory Plasticity
Authors: Wu Yue‐Yue , Liu Lan , Zou Jia‐Hao , Liu Ju‐Qing , Hu Yi‐Chun , Ban Chao‐Yi , Li Fei‐Yang , Li Zi‐Fan , Zhang He‐Shan , Zhou Zhe , Zhao Jian‐Feng , Xiu Fei , Huang Xiao , Zhao Qiang , Eginligil Mustafa , Huang Wei 
Published: January 2022

AbstractAfterglow materials are of primary interest in optoelectronics and bioelectronics. Here, a long‐lived phosphorescence afterglow is reported from carboxylated carbon nanotubes (c‐CNTs) confined within boron oxynitride (BNO). The formation of covalent and hydrogen bonds in c‐CNT@BNO enhances the rigidity of the hybrid structure and alleviates the non‐radiative deactivation of excited triplet states, leading to room‐temperature phosphorescence (RTP). The afterglow material exhibits an ultra‐long RTP lifetime of up to 476.6 ms, with an afterglow time of 4.0 s, distinguishable by naked eyes. This unprecedented feature makes c‐CNT act like a light‐sensitive neuron and it is possible to achieve memorizing−forgetting behavior in the form of optical memory plasticity, owing to photons’ capture‐and‐slow‐release process. In analogy to the biological brain, both memory strength and forgetting time are proportional to learning exercise, including the intensity and time of irradiation training. The study provides an effective protocol for the synthesis of afterglow nanomaterials, extending their application to brain‐like intelligent technology.
The Linkage between Sustainable Development Goals 9 and 11: Examining the Association between Sustainable Urbanization and Intellectual Property Rights Protection
Authors: Gao Xing , Zhu Jin , He Bao‐Jie 
Published: January 2022

AbstractUnited Nations Sustainable Development Goals (SDGs) 9 and 11 advocate industrial innovation and sustainable cities, respectively, although how sustainable urban development ensures the protection of innovative achievements remains understudied. Employing the Spatial Durbin Model, this study examines how the protection of intellectual property rights (IPRs) has affected sustainable urbanization using the case of the Huaihai economic zone (HEZ), China. Adopting a theoretical and empirical approach, the study seeks to understand how sustainable urbanization affects the protection of IPRs, and explores the spatial spillover from the perspectives of economic growth structure, technological progress, economic agglomeration and social welfare enhancement, taking into account also the protection of IPRs at a sub‐national level. The results indicate that sustainable urbanization is positively related to the protection of IPRs (as can be understood from the four abovementioned aspects of sustainable urbanization), that the spatial spillover effects of sustainable urbanization on the protection of IPRs and distance from the central city are significant, and that foreign direct investment (FDI)—a significant driving force in China's urbanization—has a negative impact.
Cellulose Nanocrystals in Sustainable Energy Systems
Authors: Calle‐Gil Raúl , Castillo‐Martínez Elizabeth , Carretero‐González Javier 
Published: January 2022

AbstractThe transition to low‐carbon emitting technologies provokes an increasing demand in energy conversion and storage systems such as fuel cells, batteries, and supercapacitors, and consequently, the need for their raw materials. The use of new chemistries from earth‐abundant precursors instead of scarce, toxic, and nondegradable components existing in current systems must be a priority in future years. Cellulose is the most abundant biopolymer on earth. Their crystalline constituents designated as cellulose nanocrystals (CNC) have been studied as functional materials due to their excellent structural and chemical properties. This review covers a recent collection of works on innocuous CNC‐based materials with special attention to the fabrication methodologies of electrodes, electrolytes, membranes, and separators. The implementation of these CNC‐derived materials in sustainable energy conversion and storage systems is also discussed.
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Authors: Alhayek Alaa , Khan Essak S. , Schönauer Esther , Däinghaus Tobias , Shafiei Roya , Voos Katrin , Han Mitchell K. L. , Ducho Christian , Posselt Gernot , Wessler Silja , Brandstetter Hans , Haupenthal Jörg , del Campo Aránzazu , Hirsch Anna K. H. 
Published: January 2022

AbstractDespite the progress in surgical techniques and antibiotic prophylaxis, opportunistic wound infections with Bacillus cereus remain a public health problem. Secreted toxins are one of the main factors contributing to B. cereus pathogenicity. A promising strategy to treat such infections is to target these toxins and not the bacteria. Although the exoenzymes produced by B. cereus are thoroughly investigated, little is known about the role of B. cereus collagenases in wound infections.In this report, the collagenolytic activity of secreted collagenases (Col) is characterized in the B. cereus culture supernatant (csn) and its isolated recombinantly produced ColQ1 is characterized. The data reveals that ColQ1 causes damage on dermal collagen (COL). This results in gaps in the tissue, which might facilitate the spread of bacteria. The importance of B. cereus collagenases is also demonstrated in disease promotion using two inhibitors. Compound 2 shows high efficacy in peptidolytic, gelatinolytic, and COL degradation assays. It also preserves the fibrillar COLs in skin tissue challenged with ColQ1, as well as the viability of skin cells treated with B. cereus csn. A Galleria mellonella model highlights the significance of collagenase inhibition in vivo.
Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture
Authors: Rommel Dirk , Mork Matthias , Vedaraman Sitara , Bastard Céline , Guerzoni Luis P. B. , Kittel Yonca , Vinokur Rostislav , Born Nikolai , Haraszti Tamás , De Laporte Laura 
Published: January 2022

AbstractIn this work, a two component microgel assembly using soft anisometric microgels that interlink to create a 3D macroporous construct for cell growth is reported. Reactive microgel rods with variable aspect ratio are produced via microfluidics in a continuous plug‐flow on‐chip gelation method by photoinitiated free‐radical polymerization of star‐polyethylene glycol‐acrylate with glycidyl methacrylate or 2‐aminoethyl methacrylate comonomers. The resulting complementary epoxy‐ and amine‐functionalized microgels assemble and interlink with each other via a ring opening reaction, resulting in macroporous constructs with pores up to several hundreds of micrometers. The level of crosslinking depends on the functionalization degree of the microgels, which also affects the stiffness and cell adhesiveness of the microgels when modified with the cell‐adhesive GRGDS‐PC peptide. Therefore, 3D spreading and growth of cells inside the macroporous structure is influenced not only by the presence of macropores but also by the mechanical and biochemical properties of the individual microgels.
Pancake Jumping of Sessile Droplets
Authors: Qian Chenlu , Zhou Fan , Wang Ting , Li Qiang , Hu Dinghua , Chen Xuemei , Wang Zuankai 
Published: January 2022

AbstractRapid droplet shedding from surfaces is fundamentally interesting and important in numerous applications such as anti‐icing, anti‐fouling, dropwise condensation, and electricity generation. Recent efforts have demonstrated the complete rebound or pancake bouncing of impinging droplets by tuning the physicochemical properties of surfaces and applying external control, however, enabling sessile droplets to jump off surfaces in a bottom‐to‐up manner is challenging. Here, the rapid jumping of sessile droplets, even cold droplets, in a pancake shape is reported by engineering superhydrophobic magnetically responsive blades arrays. This largely unexplored droplet behavior, termed as pancake jumping, exhibits many advantages such as short interaction time and high energy conversion efficiency. The critical conditions for the occurrence of this new phenomenon are also identified. This work provides a new toolkit for the attainment of well‐controlled and active steering of both sessile and impacting droplets for a wide range of applications.