bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural correlations between cognitive deficits and emotion regulation strategies: understanding emotion dysregulation in depression from the perspective of cognitive control and cognitive biases
Authors: Gao Wei , Yan XinYu , Yuan JiaJin 
Published: November 2022

Abstract
The link between cognitive function and emotion regulation may be helpful in better understanding the onset, maintenance, and treatment for depression. However, it remains unclear whether there are neural correlates between emotion dysregulation and cognitive deficits in depression. To address this question, we first review the neural representations of emotion dysregulation and cognitive deficits in depression (including deficits in cognitive control and cognitive biases). Based on the comparisons of neural representations of emotion dysregulation versus cognitive deficits, we propose an accessible and reasonable link between emotion dysregulation, cognitive control, and cognitive biases in depression. Specifically, cognitive control serves the whole process of emotion regulation, whereas cognitive biases are engaged in emotion regulation processes at different stages. Moreover, the abnormal implementation of different emotion regulation strategies in depression is consistently affected by cognitive control, which is involved in the dorsolateral, the dorsomedial prefrontal cortex, and the anterior cingulate cortex. Besides, the relationship between different emotion regulation strategies and cognitive biases in depression may be distinct: the orbitofrontal cortex contributes to the association between ineffective reappraisal and negative interpretation bias, while the subgenual prefrontal cortex and the posterior cingulate cortex underline the tendency of depressed individuals to ruminate and overly engage in self-referential bias. This review sheds light on the relationship between cognitive deficits and emotion dysregulation in depression and identifies directions in need of future attention.
Rotating black holes in 3D Hořava gravity revisited
Authors: Park Mu-In 
Published: November 2022

Abstract
I revisit rotating black hole solutions in 3D Hořava gravity with z = 2 as a simpler set-up of the renormalizable quantum gravity à la Lifshitz [Zh. Eksp. Teor. Fiz. 11, 255 (1941)] and DeWitt [Phys. Rev. 160, 1113 (1967)]. The solutions have a curvature singularity at the origin for a non-vanishing rotation parameter ${\cal J}$, unlike the black holes in 3D Einstein gravity. For anti-de Sitter space, there are black hole event horizons as usual and the singularity is not naked, in agreement with cosmic censorship. On the other hand, for flat or de Sitter space, the earlier solution also has a cosmic-censorship problem because there are no conventional black hole horizons as in Einstein gravity, other than the usual cosmological horizon for the latter case, so that the singularity could be naked in Hořava gravity. However, with the help of recent corrections, I show that the solutions have a peculiar black hole horizon at the origin so that the singularity is not naked even without the conventional black hole horizons in the flat or de Sitter cases, due to Lorentz-violating higher-derivative terms. On the other hand, I also note that a new “cosmological” horizon exists even for the flat case, contrary to the usual wisdom, due to the combined effects of the higher derivatives and the angular-momentum barrier. I study a unified treatment of their unusual black hole thermodynamics for the flat and de Sitter spaces, as well as the anti-de Sitter space, which might be due to the lack of absolute horizons in Lorentz-violating gravity.
The Laryngeal Mask
Authors: Zaichkin Jeanette , McCarney Linda D. , Rhein Michelle 
Published: November 2022

Background:
Since 2005, the Neonatal Resuscitation Program (NRP) has recommended the laryngeal mask (LM) as an alternative airway when positive-pressure ventilation (PPV) is unsuccessful and intubation is unsuccessful or unfeasible. There is a paucity of literature regarding LM use in high-resource countries; however, anecdotal information and recent studies suggest low implementation.

Purpose:
This article increases awareness of LM safety and efficacy, provides guidance for determining nursing scope of practice, and includes suggestions for developing a training program.

Methods:
Methods include considering NRP customers' questions, recent systematic reviews of the literature, how NRP recommendations are developed, how to determine nursing scope of practice, and how to develop a training program.

Findings/Results:
Recent studies support the NRP recommendation to use the LM as a rescue airway when PPV fails and intubation is not feasible. The LM provides more effective PPV than face-mask ventilation. The LM may be effective as the initial PPV device for infants of at least 34 weeks' gestation. To use the LM, nurses may require training, which may include a simulation-based curriculum.

Implications for Practice:
Nurses can increase their awareness of the advantages of LM use, determine their scope of practice, and develop a training program. When face-mask ventilation is unsuccessful and intubation is unfeasible, LM insertion will likely increase the newborn's heart rate and avoid intubation.

Implications for Research:
Future research should determine training requirements, efficacy of the LM as the initial PPV device in high-resource settings, and LM use during complex resuscitation and in preterm newborns.
Single Seminal Vesicle Metastasis From Dorsal Melanoma Detected by 18F-FDG PET/CT and Confirmed by Biopsy
Authors: Testart Dardel Nathalie , Isenborghs Elsa , Valerio Massimo , Michielin Olivier , Schaefer Niklaus 
Published: November 2022

Abstract
This case shows an unusual presentation of a melanoma metastasis, visualized by 18F-FDG digital PET/CT, with a single abnormal focal uptake in the right seminal vesicle. Histologic analysis confirmed a melanoma metastasis, subsequently treated by stereotactic radiation therapy. We illustrate an unusual and single-site millimetric melanoma metastasis detected by 18F-FDG PET/CT, highlighting the high performance of state-of-the-art digital PET/CT and the importance of a multidisciplinary approach in treatment and follow-up of melanoma patients. In this case, histological diagnosis was essential for correct diagnosis and adequate clinical management of the patient.
Identification of novelPlasmodium vivaxproteins associated with protection against clinical malaria
Authors: Mazhari Ramin , Takashima Eizo , Longley Rhea J , Ruybal-Pesantez Shazia , White Michael T , Kanoi Bernard N , Nagaoka Hikaru , Kiniboro Benson , Siba Peter , Tsuboi Takafumi , Mueller Ivo 
Published: November 2022

AbstractAs progress towards malaria elimination continues, the challenge posed by the parasite speciesPlasmodium vivaxhas become more evident. In many regions co-endemic forP. vivaxandPlasmodium falciparum, as transmission has declined the proportion of cases due toP. vivaxhas increased. Novel tools that directly targetP. vivaxare thus warranted for accelerated elimination. There is currently no advanced vaccine forP. vivaxand only a limited number of potential candidates in the pipeline. In this study we aimed to identify promisingP. vivaxproteins that could be used as part of a subunit vaccination approach. We screened 342P. vivaxprotein constructs for their ability to induce IgG antibody responses associated with protection from clinical disease in a cohort of children from Papua New Guinea. This approach has previously been used to successfully identify novel candidates. We were able to confirm previous results from our laboratory identifying the proteins reticulocyte binding protein 2b and StAR-related lipid transfer protein, as well as at least four novel candidates with similar levels of predicted protective efficacy. Assessment of theseP. vivaxproteins in further studies to confirm their potential and identify functional mechanisms of protection against clinical disease are warranted.
Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension
Authors: Weng Shinuo , Wallingford John B. 
Published: November 2022

SummaryConvergent extension (CE) is an evolutionarily conserved developmental process that elongates tissues and organs via collective cell movements known as cell intercalation. Here, we sought to understand the mechanisms connecting cell behaviors and tissue shaping. We focus on an often-overlooked aspect of cell intercalation, the resolution of 4-cell rosettes. Our data reveal that polarized cellular forces are involved in a timely rosette resolution, which in turn, enables propagation of such cellular forces, facilitating the propagation of tissue-scale CE. Conversely, delayed rosette resolution leads to a subtle but significant change of tissue-wide cell packing and exerts a profound impact by blocking force propagation, resulting in CE propagation defects. Our findings propose a collaborative nature of local cell intercalations in propagating tissue-wide CE. It unveils a multiscale biomechanical synergy underpinning the cellular mechanisms that orchestrate tissue morphogenesis during CE.Highlights4-cell rosette is resolved by a two-step process: t-junction extension, then rotation.Delayed t-junction rotation significantly impacts the tissue-wide cell packing configuration.Timely resolved 4-cell rosettes enable polarized force coupling and propagation bothin silicoandin vivo.Polarized force propagation is involved in the propagation of tissue shaping.
Galectin approach to lower covid transmission - Drug Development for clinical use
Authors: Sigamani Alben , Mayo Kevin H , Chen-Walden Hana , Reddy Surender , Platt David 
Published: November 2022

AbstractBackgroundSARS-CoV-2 vaccines play an important role in reducing disease severity, hospitalization, and death, although they failed to prevent the transmission of SARS-CoV-2 variants. Therefore, an effective inhibitor of galectin-3 (Gal-3) could be used to treat and prevent transmission of COVID-19. ProLectin-M (PL-M), a Gal-3 antagonist, has been shown to interact with Gal-3 and thus prevent cellular entry of SARS-CoV-2 in previous studies.AimThe present study aimed to further evaluate the therapeutic effect of PL-M tablets in 34 subjects with COVID-19 disease, in addition to determining the mechanism of PL-M in preventing SARS-CoV-2 cell entry by NMR studies.MethodsThe efficacy of PL-M was evaluated in a randomized, double-blind, placebo-controlled clinical study in patients with mild to moderately severe COVID-19. Primary endpoints included changes in absolute RT-PCR Ct values of the nucleocapsid and open reading frame (ORF) genes from baseline to days 3 and 7. The incidence of adverse events, changes in blood biochemistry, inflammatory biomarkers, and levels of antibodies against COVID-19 were also evaluated as part of the safety evaluation.In vitro1H-15N HSQC NMR spectroscopy studies were also performed to determine the interactions of PL-M with Gal-3 and the S1 spike protein of SARS-CoV-2.ResultsPL-M treatment significantly (p = 0.001) increased RT-PCR cycle counts for N and ORF genes on days 3 (Ct values 32.09 and 30.69 ± 3.38, respectively) and 7 (Ct values 34.91 ± 0.39 and 34.85 ± 0.61, respectively) compared to placebo. On day 3, 14 subjects in the PL-M group had cycle counts for the N gene above the cut-off of 29 (target cycle count 29), while on day 7 all subjects had cycle counts above the cut-off. Ct values in placebo subjects were consistently less than 29, and no placebo subjects were RT-PCR negative, until day 7.1H-15N HSQC NMR spectroscopy revealed that PL-M specifically binds Gal-3 in the same way as the structurally similar NTD of the SARS-CoV-2 S1 subunit.ConclusionPL-M is safe and effective for clinical use in reducing viral load and promoting rapid viral clearance in COVID-19 patients by inhibiting SARS-CoV-2 entry into cells through inhibition of Gal-3.
Nuclear poly-glutamine aggregates rupture the nuclear envelope and hinder its repair
Authors: Korsten Giel , Pelle Robin , Hoogenberg Baukje , Kampinga Harm H. , Kapitein Lukas C. 
Published: November 2022

AbstractHuntington’s disease (HD) is caused by a poly-glutamine expansion of the huntingtin protein, resulting in the formation of poly-glutamine aggregates. The mechanisms of toxicity that result in the complex HD pathology remain only partially understood. Here we show that nuclear polyglutamine aggregates deform the nuclear envelope (NE) and induce NE ruptures that are often repaired incompletely. These ruptures coincide with deformations of the nuclear lamina and lead to lamina scar formation. Expansion microscopy enabled resolving the ultrastructure of nuclear aggregates and revealed polyglutamine fibrils sticking into the cytosol at rupture sites, suggesting a mechanism for incomplete repair. These findings implicate nuclear polyQ aggregate-induced loss of NE integrity as a potential contributing factor to Huntington’s disease and other polyglutamine diseases.One-sentence summaryAggregates associated with Huntington’s Disease induce ruptures of the nuclear envelop that compromise its barrier function
The effects of gamma-aminobutyric acid (GABA) on working memory and attention: A randomised, double-blind, placebo-controlled, crossover trial
Authors: Altınok Ahmet , Karabay Aytaç , de Jong Joost , Balta Gülşen , Akyürek Elkan G. 
Published: November 2022

ABSTRACTBackgroundγ-aminobutyric acid (GABA) is a primary inhibitory neurotransmitter that plays a significant role in the central nervous system. Studies on both animals and humans show it has the pharmacological potential for reducing the impact of cognitive disorders, as well as enhancing cognitive functions and mood. However, its specific effects on human attention and working memory have not yet been extensively studied.AimsIn this randomised, double-blind, placebo-controlled, and crossover trial, we aimed to test whether the administration of 800 mg GABA, dissolved in a drink, acutely affected visual working memory maintenance, as well as temporal and spatial attention in healthy adults.MethodsThe participants were 32 young adults (16 females and 16 males). Working memory recall precision, spatial attention and temporal attention were measured by a delayed match-to-sample task, a visual search task, and a speeded rapid serial visual presentation task, respectively. Participants completed two experimental sessions (GABA and Placebo) in randomized and counterbalanced order. In each session, forty-five minutes after administration of the drink, they completed the all three of the aforementioned cognitive tasks.ResultsLinear mixed model analysis results showed that GABA increased visual search time, compared to the placebo, but did not affect visual search accuracy, temporal attention, nor visual working memory precision.ConclusionsThe results suggest that GABA increases visual search time but does not affect temporal attention and memory, and that previously reported effects on cognition might rely on other functions.
Interplay of the folded domain and disordered low-complexity domains along with RNA sequence mediate efficient binding of FUS with RNA
Authors: Balasubramanian Sangeetha , Maharana Shovamayee , Srivastava Anand 
Published: November 2022

AbstractRNA binding ability of Fused in Sarcoma (FUS) protein is crucial to its cellular function. Our molecular simulation study on FUS-RNA complex provides atomic resolution insights into the observations from biochemical studies and also illuminate our understanding of molecular driving forces that mediate the structure, stability, and interaction of RRM and RGG domains of FUS with a stem-loop junction RNA. We observe a clear cooperativity and division of labour among the ordered (RRM) and disordered domains (RGG1 and RGG2 domain) of FUS that leads to an organized and tighter RNA binding. Irrespective of the length of RGG2, the RGG2-RNA interaction is confined to the stem-loop junction and the proximal stem regions. On the other hand, the RGG1-RNA interactions are primarily with the longer RNA stem. We find that the C-terminus of RRM, which make up the “boundary residues” that connect the folded RRM with the long disordered RGG2 stretch of the protein, plays a critical role in RNA binding with the RRM domain. Our study provides high-resolution molecular insights into the FUS-RNA interactions and forms the basis for understanding the molecular origins of full-length FUS interaction with RNA.
“A very special song from Queen to you!” The role of music in destination promotional videos
Authors: Coronel Monica , Irimiás Anna 
Published: November 2022

Purpose
This study aims to contribute to the discussion on the interplay between music and destination advertising by exploring the roles of music in destination promotional videos (DPVs).

Design/methodology/approach
Eight focus group discussions on DPVs about Budapest (Hungary) were assessed through thematic analysis. Individuals’ interactions with and perceptions of advertising can be explored in depth through the former, whereas the latter allowed to identify the roles of music in DPVs.

Findings
Results show that music plays a very important role in DPVs in which it acts as a conveyor. Viewers associate a DPV’s musical elements and genre with a destination’s character. Here, the use and remix of traditional music was felt to be controversial because of its ability to communicate cultural identity. The music caught the audience’s attention, elicited emotions in them and made them think about the destination in question. An original music track can make a video memorable.

Research limitations/implications
A convenience sample was used with international and Hungarian university students for the focus groups.

Practical implications
Music is a powerful conveyor of the particular characteristics of a destination and if the structural elements of music, such as tempo, rhythm and dynamics, are chosen appropriately, tourism marketers can create compelling promotional videos. By recognising that different audiences are attracted by different genres of music, marketers can target specific tourist segments. Furthermore, tourism marketers are advised to ask locals’ opinions about which music best represents their city’s cultural identity.

Originality/value
Through an understanding of the important role of music in DPVs, this study provides a novel insight into assessing young people’s cognitive and affective responses to music in promotional videos.
Pay inequality and annual report readability
Authors: Park KoEun 
Published: November 2022

PurposeThis study examines the relation between pay inequalities in top management teams and how efficiently firms convey valuation-relevant information to investors. Given that reward comparisons with reference groups create feelings of inequity, top management team pay inequalities can impair the information environment. This manifests into lengthier or less readable financial reports.Design/methodology/approachThis paper employs an ordinary least squares (OLS) regression model to test whether and how the pay distribution in the top management team is associated with the readability of the annual report. It also employs a two-stage least squares (2SLS) regression model to further address the endogeneity concern. Lastly, it conducts cross-sectional analyses to examine heterogeneity in the observed relation.FindingsUsing the intra-firm pay gap as a proxy for pay inequality and file size, Bog Index and Fog Index of the 10-K filings as a proxy for financial report readability, the author finds that firms with larger pay gaps exhibit lengthier or less readable 10-K filings. The main findings are robust to the use of an instrumental variable approach. She finds some evidence that the relation is less pronounced when pay gaps are justified by explicit legal authority of CEOs or high ability of CEOs. The main results are robust to considerations of alternative explanations.Originality/valueThis paper adds a new dimension to the debate on pay inequality by studying pay gaps in the top management team and financial report readability. The author's findings have important implications for executive compensation policies and for corporate disclosure policies.
3D‐printed procedural task trainer for the aspiration of penile corpus cavernosa in ischaemic priapism
Authors: Harvey Steven B , Bezzina Andrew J , Mac Partlin Matthew , Caldwell Janice , Short Leah 
Published: November 2022

AbstractObjectiveThe development and initial clinical assessment of a novel 3D‐printed procedural task trainer for the aspiration of penile corpus cavernosa in ischaemic priapism.MethodsA task trainer for the aspiration of penile corpus cavernosa was designed and manufactured using commercially available 3D printing equipment. The trainer was assessed in two separate training sessions led by faculty investigators. Participants in the sessions were asked to complete a post‐procedure survey with regards to the utility and realism of the task trainer.ResultsThe participants (n = 14) covered a broad spectrum of clinician types. The trainer was perceived by the participants as being anatomically realistic, and especially while under drapes provided a reasonable facsimile of real clinical setup. The trainer proved resilient to multiple attempts at aspiration by multiple participants.ConclusionsParticipant and facilitator feedback indicates that the task trainer is a useful platform to train for what is a low frequency, but high stakes, procedure. Small numbers of participants preclude statistical rigour and certainty regarding overall performance of the trainer. However, the uniformity in the responses would suggest that this is indeed a task trainer that is ‘fit for purpose’.
The effect of metformin or dipeptidyl peptidase 4 inhibitors on clinical outcomes in metastatic non‐small cell lung cancer treated with immune checkpoint inhibitors
Authors: Yang Jieun , Kim Se Hyun , Jung Eun Hee , Kim Sang‐A , Suh Koung Jin , Lee Ji Yun , Kim Ji‐Won , Kim Jin Won , Lee Jeong‐Ok , Kim Yu Jung , Lee Keun‐Wook , Kim Jee Hyun , Bang Soo‐Mee , Lee Jong Seok 
Published: November 2022

AbstractBackgroundPreclinical data have shown the immunomodulatory effects of metformin and dipeptidyl peptidase 4 (DPP4) inhibitors in patients with diabetes. However, its clinical impact remains unclear in lung cancer.MethodsBetween 2017 and 2021, 466 patients received ICI monotherapy. Patients were categorized into concurrent (MET; metformin or combination of metformin and DPP4 inhibitor) and without concomitant (NMET; nonmetformin/DPP4 inhibitors) administration of metformin and DPP4 inhibitors groups at least 8 weeks before and during ICI therapy. The primary objectives were the objective response rate (ORR) and progression‐free survival (PFS). The second objective was to evaluate the overall survival (OS) and the occurrence of immune‐related adverse events (irAEs).ResultsAmong 466 patients, 89 (19.0%) and 377 (81%) were categorized into the MET and NMET groups, respectively. MET group had a significantly higher ORR (MET group: 24.7% vs. NMET group: 14.8%, p = 0.025) and longer PFS than those in the NMET group (MET group 5.1 month vs. NMET group 2.8 months, p = 0.018). After patients were stratified based on the prior line of therapy and PD L1 expression status, the PFS of the second‐line therapy and PD L1 ≥50 was significantly higher in the MET than in the NMET group. The proportion of patients experiencing all‐grade irAEs was numerically higher in the MET group (19.1%) than in the NMET group (14.3%), without statistical significance (p = 0.382).ConclusionsConcurrent use of metformin and DPP4 inhibitors with ICIs significantly improved the clinical outcomes without increasing the incidence of irAEs in NSCLC.