bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Cell Source on Mesenchymal Stem Cell Behavior and Osteogenic Differentiation of Buccal Fat Pad and Dental Pulp Stem Cells, an In Vitro Study
Authors: Arpornmaeklong Premjit , Srinual Nida , Pripatnanont Prisana 
Published: May 2022

Objective: The buccal fat pad is a source of adipose stem cells accessible from the oral cavity and dental pulp is a common dental source of stem cells. This study aimed to assess the biological behaviors and osteogenic differentiation of human buccal fat pad adipose-derived stem cells (hBFP-ADSCs) and human dental pulp derived stem cells (hDPSCs).Material and Methods: Buccal fat pads (595.4±80 mg) and dental pulp from 2 wisdom teeth were obtained from 3 matched donors and hBFP-ADSCs and hDPSC cells, respectively, and isolated. The isolated cells were sequentially expanded through passages 5, 10, and 15 for analysis. Cell growth, osteogenic differentiation, and cell senescence were investigated.Results: HBFP-ADSCs and hDPSCs exhibited different cell morphologies and behaviors. Cell expansion was associated with the decrease of cell growth and in vitro mineralization of hDPSCs. The cell yields of hBFP-ADSCs and hDPSCs at the primary passage were 3.2x10^5 ±9.9x10^3 cells/100 mg and 1.13x10^6 ±2.4x10^5 cells/tooth, respectively. The expanded cells exhibited a limited life span and maintained normal karyotypes at the late cell expansion stage.Conclusion: HBFP-ADSCs showed steady cell growth, high osteogenic differentiation potential, tissue availability, and minimal in vitro cell expansion. The availability and accessibility of hBFP-ADSCs would enable clinical applicability as a stem cell source for bone regeneration.
Use of Digital Health Interventions in Sub-Saharan Africa for Health Systems Strengthening Over the Last 10 Years: A Scoping Review Protocol
Authors: Kipruto Hillary , Muneene Derrick , Droti Benson , Jepchumba Violet , Okeibunor Chukwudi Joseph , Nabyonga-Orem Juliet , Karamagi Humphrey Cyprian 
Published: May 2022

BackgroundDigital Health Interventions (DHIs) refers to the utilization of digital and mobile technology to support the health system in service delivery. Over the recent years, advanced computing, genomics, and artificial intelligence are considered part of digital health. In the context of the World Health Organization (WHO) global strategy 2020–2025, digital health is defined as “the field of knowledge and practice associated with the development and use of digital technologies to improve health.” The scoping review protocol details the procedure for developing a comprehensive list of DHIs in Sub-Saharan Africa and documenting their roles in strengthening health systems.Method and AnalysisA scoping review will be done according to the Joanne Briggs institute reviewers manual and following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist and explanation. The protocol has been registered at the Open Science Framework (OSF) database at https://osf.io/5kzq7. The review will include DHIs conceptualized/developed/designed, adapted, piloted, deployed, scaled up, and addressing health challenges in Sub-Saharan Africa. We will retrieve data from the global DHI repository-the WHO Digital Health Atlas (DHA)- and supplement it with information from the WHO eHealth Observatory, eHealth Survey (2015), and eHealth country profiles report. Additional searches will be conducted in four (4) electronic databases: PubMed, HINARI-Reasearch4Life, Cochrane Library, and Google Scholar. The review will also include gray literature and reference lists of selected studies. Data will be organized in conceptual categories looking at digital health interventions' distinct function toward achieving health sector objectives.DiscussionSub-Saharan Africa is an emerging powerhouse in DHI innovations with rapid expansion and evolvement. The enthusiasm for digital health has experienced challenges including an escalation of short-lived digital health interventions, duplication, and minimal documentation of evidence on their impact on the health system. Efficient use of resources is important when striving toward the use digital health interventions in health systems strengthening. This can be achieved through documenting successes and lessons learnt over time.ConclusionThe review will provide the evidence to guide further investments in DHIs, avoid duplication, circumvent barriers, focus on gaps, and scale-up successful interventions.
Association Between Low Muscle Mass and Gastric Hyperplastic and Inflammatory Polyps in Chinese Asymptomatic Adult Males
Authors: Wang Na , Chen Mengjun , Lin Chunjing , Lin Weihong 
Published: May 2022

BackgroundGastric polyp is an abnormally proliferative or neoplastic growth of the gastric mucosa, with a degree of tendency to transform into gastric cancer. Lack of physical activity that is significantly related to low muscle mass (LMM) and muscle strength has been identified to be associated with gastric polyps. In this study, we examine the association of LMM and different histological types of gastric polyps among Chinese asymptomatic adult males.MethodsIn total, 1,742 male adults undergoing bioelectrical impedance analysis and upper gastrointestinal endoscopies were included. Univariate and multivariate logistic regression models were used to analyze the effect of LMM on the risk of gastric polyps and different histological types.ResultsBy univariate and multivariate analyses, LMM (OR: 1.689, 95%CI: 1.046–2.726, p = 0.032) kept independent effect on risk of gastric polyps. When ratio of appendicular skeletal muscle mass to body mass index(ASM/BMI) was brought into the analyses, it was identified to be negatively correlated with occurrence of gastric polyps (OR: 0.744, 95%CI: 0.566–0.977, p = 0.033). For different pathological types, LMM showed different effect on occurrence of gastric polyps. LMM was an independent indicator for hyperplastic and inflammatory polyps (OR: 2.378, 95%CI: 1.288–4.389, p = 0.006), rather than fundic gland polyps (OR: 1.013, 95%CI: 0.473–2.173, p = 0.973).ConclusionIn general, LMM was an independent indicator for hyperplastic and inflammatory polyps occurrence in Chinese asymptomatic adult males.
Contrast-Enhanced Spectral Mammography-Based Prediction of Non-Sentinel Lymph Node Metastasis and Axillary Tumor Burden in Patients With Breast Cancer
Authors: Wu Xiaoqian , Guo Yu , Sa Yu , Song Yipeng , Li Xinghua , Lv Yongbin , Xing Dong , Sun Yan , Cong Yizi , Yu Hui , Jiang Wei 
Published: May 2022

PurposeTo establish and evaluate non-invasive models for estimating the risk of non-sentinel lymph node (NSLN) metastasis and axillary tumor burden among breast cancer patients with 1–2 positive sentinel lymph nodes (SLNs).Materials and MethodsBreast cancer patients with 1–2 positive SLNs who underwent axillary lymph node dissection (ALND) and contrast-enhanced spectral mammography (CESM) examination were enrolled between 2018 and 2021. CESM-based radiomics and deep learning features of tumors were extracted. The correlation analysis, least absolute shrinkage and selection operator (LASSO), and analysis of variance (ANOVA) were used for further feature selection. Models based on the selected features and clinical risk factors were constructed with multivariate logistic regression. Finally, two radiomics nomograms were proposed for predicting NSLN metastasis and the probability of high axillary tumor burden.ResultsA total of 182 patients [53.13 years ± 10.03 (standard deviation)] were included. For predicting the NSLN metastasis status, the radiomics nomogram built by 5 selected radiomics features and 3 clinical risk factors including the number of positive SLNs, ratio of positive SLNs, and lymphovascular invasion (LVI), achieved the area under the receiver operating characteristic curve (AUC) of 0.85 [95% confidence interval (CI): 0.71–0.99] in the testing set and 0.82 (95% CI: 0.67–0.97) in the temporal validation cohort. For predicting the high axillary tumor burden, the AUC values of the developed radiomics nomogram are 0.82 (95% CI: 0.66–0.97) in the testing set and 0.77 (95% CI: 0.62–0.93) in the temporal validation cohort.DiscussionCESM images contain useful information for predicting NSLN metastasis and axillary tumor burden of breast cancer patients. Radiomics can inspire the potential of CESM images to identify lymph node metastasis and improve predictive performance.
Clinical Features and Risk Factors of Severe Pneumonia in Children With Acute Lymphoblastic Leukemia
Authors: Liu Chun-yan , Li Cheng 
Published: May 2022

ObjectiveThis study aims to analyze the clinical characteristics of pediatric acute lymphoblastic leukemia (ALL) complicated by pneumonia and the risk factors of severe cases to preliminarily construct a prediction model for ALL complicated by severe pneumonia.MethodsA retrospective analysis was carried out on the clinical data of children diagnosed with ALL complicated by pneumonia hospitalized at the Department of Pediatrics of the Affiliated Hospital of Southwest Medical University between January 2013 and December 2020. The risk factors of severe ALL complicated by pneumonia were investigated with logistic regression analysis, and the risk prediction model was constructed.ResultsA total of 116 cases of pediatric ALL complicated by pneumonia were analyzed. There were 71 cases of mild pneumonia and 45 cases of severe pneumonia. The main clinical manifestations were cough in 112 cases and fever in 109. Pathogens were detected in 23 cases. Multiple regression factor analysis indicated that the use of hormones (OR 4.001, 95% CI: 1.505–10.632), neutropenia or agranulocytosis (OR 7.472, 95% CI: 2.710–20.602), hemoglobin (Hb) &lt; 90 g/L (OR 3.270, 95% CI: 1.256~8.516), and C-reactive protein (CRP) &gt;15 mg/L (OR 3.253, 95% CI: 1.209~8.751) were independent risk factors that were associated with severe pneumonia. Logistic regression was used to establish the risk prediction model of ALL with severe pneumonia. The p-value was 0.659. The area under the receiver operating characteristic curve was 0.851, and the sensitivity and specificity were 84.4 and 71.8%, respectively.ConclusionThe development of severe pneumonia may be affected by the use of hormones, neutropenia or agranulocytosis, Hb &lt; 90 g/L, and CRP &gt; 15 mg/L. The prediction model based on the risk factors is effective, which can provide a reference for the clinical evaluation of acute lymphoblastic leukemia with severe pneumonia.
Incision and Drainage With Primary Fistulotomy of Perianal Abscess Is Safe and Effective in Neonates: A Long-Term Follow-Up Study
Authors: Yin Wanbin , Li Laian , Su Lin , Wang Shuai 
Published: May 2022

ObjectivePerianal abscess (PA) in neonates is poorly understood, and its management remains controversial. The aim of this study was to compare incision and drainage (ID) with or without primary fistulotomy in the management of neonatal first-time PA.MethodsA retrospective comparative study was conducted for neonates with first-time PA treated with incision and drainage with primary fistulotomy (IDF) vs. ID between 2008 and 2017.ResultsIn total, 138 patients (137 boys and 1 girl) were identified; 65 in the IDF group and 73 in the ID group. The median follow-up was 6.5 years (range 4–13 years). Baseline characteristics were similar between the 2 groups. The cure rate in the IDF group (98.5%, 64/65) was significantly higher than that in the ID group (80.8%, 59/73; p = 0.001). The rate of fistula formation in the IDF group (1.5%, 1/65) was significantly lower than that in the ID group (13.7%, 10/73; p = 0.01). The rate of abscess recurrence was not statistically different (p = 0.12), even though the IDF group (0%, 0/65) seemed to have a better outcome than the ID group (5.5%, 4/73). No fecal incontinence was observed in any of our patients.ConclusionsFirst-time PA in neonates can be treated safely and effectively by the IDF or by ID alone. The former may be advantageous over the latter in terms of the rate of cure and fistula formation.
Stevens-Johnson Syndrome Following Non-steroidal Anti-inflammatory Drugs: A Real-World Analysis of Post-marketing Surveillance Data
Authors: Shao Qi-hui , Yin Xue-dong , Zeng Na , Zhou Zhi-xuan , Mao Xin-yu , Zhu Yan , Zhao Bin , Li Zhi-ling 
Published: May 2022

Background:The Stevens-Johnson syndrome (SJS) is a severe skin reaction to non-steroidal anti-inflammatory drugs (NSAIDs), and can even be life-threatening. However, there are still few real-world studies to compare the specific differences in the adverse effects of skin and mucosal invasion.MethodsDisproportionality analysis and Bayesian analysis were devoted to data-mining of the suspected SJS after using NSAIDs based on the FDA's Adverse Event Reporting System (FAERS) from January 2004 to March 2021. The times to onset, fatality, and hospitalization rates of antipyretic analgesic-associated SJS were also investigated.ResultsA total of 1,868 reports of SJS adverse events were identified with NSAIDs. Among 5 NSAIDs monotherapies we studied (acetaminophen, ibuprofen, aspirin, diclofenac and celecoxib), ibuprofen had the highest association with SJS based on the highest reporting odds ratio (ROR = 7.06, 95% two-sided CI = 6.59–7.56), proportional reporting ratio (PRR = 6.98, χ2 = 4201.14) and empirical Bayes geometric mean (EBGM = 6.78, 95% one-sided CI = 6.40). However, ibuprofen-associated SJS had the lowest fatality rate (6.87%, p &lt; 0.0001) and the highest hospitalization rate (79.27%, p &lt; 0.0001). Celecoxib-associated SJS had the latest time to onset (317.56 days, p &lt; 0.0001). Diclofenac-associated SJS cases appeared to be associated with the highest risk of death (25.00%, p &lt; 0.0001).ConclusionsThe analysis of FAERS data provides a more accurate profile of the incidence and prognosis of SJS after NSAIDs treatment, enabling continued surveillance and timely intervention in patients at risk of SJS following these NSAIDs.
Reconstruction of the Palmar Defect of the Hand with a Sensory Medial Plantar Artery Flap
Authors: Li Jiayu , Luo Xuchao , Zou Yonggen 
Published: May 2022

BackgroundThere are many approaches to repair the palmar defect of the hand, but due to the complex tissue structure, versatile functions, and high restoration demands, the repair of the palmar defect of the hand has always been a difficult task. Choosing suitable flaps to repair this kind of injury is always a tough challenge for the reconstructive surgeon because of the limitation of the number of arteries in the recipient hand and high restoration demands. The sensory medial plantar artery flap is considered as the ideal choice to repair the palmar defect of the hand. Based on this technique, in the current study, we used the free sensory medial plantar artery flap to reconstruct the palmar defect of the hand and obtained satisfactory results. The purpose of this study was to review the use of the sensory medial plantar artery flap for the reconstruction of the palmar defect of the hand.MethodFrom January 2019 to December 2020, nine patients with the palmar defect of the hand underwent extremity reconstruction by a sensory medial plantar artery flap. The indications for this surgery were that the palmar defect of the hand need to be reconstructed and both anterior and posterior tibial arteries should be free-flowing. Patients who had systemic diseases such as diabetes millitus, vascular diseases, heavy smoking histories, and injuries of the donor site were ruled out for the surgery.ResultsNine patients were successfully treated by using a sensory medial plantar artery flap, with a mean age of 39.44 (range 19–58) years. Five of the patients were male and the remaining four were female. Seven of them had a machine crush, and the other two suffered thermal injury. In all cases, reconstruction was performed during the second stage of treatment. All flaps survived completely, and all of the donor sites healed well in Stage 1, except for one case of ischaemic skin necrosis due to tight sutures, which healed after suture removal.ConclusionOur experience showed that the free sensory medial plantar artery flap was an alternative for one-stage reconstruction of the soft-tissue defect in the palm of the hand. This flexible approach not only repaired the soft-tissue defect, but also offered a satisfactory recovery of the sensory of the palm with minimal donor site morbidity.
Educational Thoughts of Perarignar C.N. Annadurai: A Content Analysis
Authors: K Chinnappan 
Published: May 2022

The objective of this paper is to describe the educational thoughts and activities of Perarignar C.N. Annadurai which are present in his writings and speeches. This article uses the descriptive method and content analysis approach to do the study. His progressive thinking on objective of education, plan of education, methods of learning and teaching, instructional language, secular education, and need of educational institutions. The primary source of this article are, books authored by Perarignar C.N. Annadurai and the books written by others on C.N. Annadurai's thoughts on education and associated activities. The betterment of an individual and the social economical cultural and political progress of a nation are constructed based on the education they possess.
Effectiveness Of Giving Biscuits To Increase Body Mass Index (Bmi) And Interpretation Of Fetal Weight In Pregnant Women Chronic Energy Deficiency
Authors: . Damayanti , Ningsih Sri Julia , Karo Karo Tati Murni , Bintang Siti Sarah 
Published: May 2022

Supplemental Feeding (PMT) is a program launched by the government to improve the nutrition of pregnant women. The prevalence of pregnant women with chronic energy deficiency problems in developing countries ranges from 15-47% with a BMI of <18.5. The country with the highest prevalence is Bangladesh at 47%. While Indonesia became the fourth largest after India with a prevalence of 35.5%. The purpose of this study is to find out the effect of PMT biscuits on the increase in the body index of pregnant women and the interpretation of fetal weight in pregnant women with chronic energy deficiencies in the working area of Puskemas Sei Suka district Sei Suka Batu Baru District in 2021.
The design of this research is quantitative with an experimental quasi approach. The population in this study is all pregnant women with chronic energy deficiency Sampling techniques use consecutive sampling where the sample is taken if it meets the criteria. Data analysis using Paired Sample T Test analysis
The results of the study obtained a significant influence on the administration of PMT biscuits on the increase in BMI of pregnant women with a value of p = 0.001 and interpretation of fetal weight (IFW) p = 0.0001 had a significant influence (p < 0.05).
From the results of research, the provision of PMT in pregnant women can increase for the mother and the fetus through the interpretation of fetal weight but must be with close supervision, this is due to the attitude of mothers who do not consider the important pattern of weight gain of pregnant women but also there is a sense of boredom in the taste. In the results of the study it can be concluded that the administration of PMT biscuits can improve the welfare of the mother and fetus.
Complete Blood Test as a New Prognostic Factor in Fournier’s Gangrene
Authors: Sunardi Ivan D. P. , Astram Ari , Toreh Christof , Arianto Eko , Langi Fredrik G. 
Published: May 2022

Abstract: Fournier’s gangrene is a form of necrotizing fasciitis that begins in the genital and perineal areas and can extend through the fascia to the groin, thigh, and even the abdominal wall. This disease is still associated with a high mortality rate even though with comprehensive therapy. Simple examination, such as a complete blood count, is widely used as a marker of inflammation and could be used as a prognostic factor for Fournier’s gangrene. This study aimed to compare Fournier Gangrene Severity Index (FGSI) and complete blood count as a prognostic factor in Fournier’s gangrene cases by using machine learning. This was an observational study with a longitudinal data collection design according to cohort method. The results obtained 30 patients with Fournier’s gangrene at Prof. Dr. R. D. Kandou Hospital, Manado. Mortality prediction analysis using algorithms of regularized generalized linear model (GLM) and support vector machine (SVM) showed that the AUCs were 98% and 97.5% for GLM and SVM respectively for the regularized GLM and SVM in the ROC curve analysis, with the superiority to the FGSI (p<0.001). In conclusion, the complete blood count could be used as a novel prognostic value of Fournier’s gangrene cases.Keywords: complete blood count; Fournier Gangrene Severity Index (FGSI); prognostic scoring system; Fournier’s gangrene Abstrak: Gangren Fournier adalah bentuk fasiitis nekrotikans yang dimulai di daerah genital dan perineum dan dapat meluas melalui fasia ke selangkangan, paha, dan bahkan dinding perut. Penyakit ini masih dikaitkan dengan angka kematian yang tinggi meskipun dengan terapi komprehensif. Pemeriksaan sederhana seperti hitung darah lengkap, banyak digunakan sebagai penanda peradangan dan dapat digunakan sebagai faktor prognostik untuk gangren Fournier. Penelitian ini bertujuan untuk membandingkan Fournier Gangrene Severity Index (FGSI) dengan pemeriksaan parameter hitung darah lengkap sebagai faktor prognostik pada kasus dengan gangren Fournier menggunakan machine learning. Jenis penelitian ialah observasional dengan desain pengumpulan data longitudinal menurut metode kohort. Hasil penelitian mendapatkan 30 pasien dengan gangren Fournier di RSUP Prof. Dr. R. D. Kandou Manado. Analisis prediksi mortalitas menggunakan algoritma Regularized Generalized Linear Model (GLM) dan Support Vector Machine (SVM) menunjukkan bahwa AUC masing-masing sebesar 98% dan 97,5% untuk GLM dan SVM tereguler pada analisis kurva ROC, dengan keunggulan dibandingkan FGSI (p<0,001). Simpulan penelitian ini ialah pemeriksaan darah lengkap dapat dijadikan sebagai faktor prognostik baru untuk kasus gangren Fournier.Kata kunci: hitung darah lengkap; Fournier Gangrene Severity Index (FGSI); sistem skoring prognostik; gangren Fournier
Covering Symmetric Sets of the Boolean Cube by Affine Hyperplanes
Authors: S. Venkitesh  
Published: May 2022

Alon and Füredi (European J. Combin., 1993) proved that any family of hyperplanes that covers every point of the Boolean cube $\{0,1\}^n$ except one must contain at least n hyperplanes. We obtain two extensions of this result, in characteristic zero, for hyperplane covers of symmetric sets of the Boolean cube (subsets that are closed under permutations of coordinates), as well as for polynomial covers of weight-determined sets of strictly unimodal uniform (SU2) grids.
As a central tool for solving our problems, we give a combinatorial characterization of (finite-degree) Zariski (Z-) closures of symmetric sets of the Boolean cube. In fact, we obtain a characterization that concerns, more generally, weight-determined sets of SU2 grids. However, in this generality, our characterization is not of the Z-closures but of a new variant of Z-closures defined exclusively for weight-determined sets, which coincides with the Z-closures in the Boolean cube setting, for symmetric sets. This characterization admits a linear time algorithm, and may also be of independent interest. Indeed, as further applications, we (i) give an alternate proof of a lemma by Alon et al. (IEEE Trans. Inform. Theory, 1988), and (ii) characterize the certifying degrees of weight-determined sets.
In the Boolean cube setting, our above characterization can also be derived using a result of Bernasconi and Egidi (Inf. Comput., 1999) that determines the affine Hilbert functions of symmetric sets. However, our proof is independent of this result, works for all SU2 grids, and could be regarded as being more combinatorial.
We also introduce another new variant of Z-closures to understand better the difference between the hyperplane and polynomial covering problems over uniform grids. Finally, we conclude by introducing a third variant of our covering problems and conjecturing its solution in the Boolean cube setting.