bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using data about accepted and rejected articles in the Journal of Dental Education to increase authors’ chances of article acceptance
Authors: Nalliah Romesh P. , Kimner Sue , Reddy Michael 
Published: March 2022

AbstractPurpose/objectivesThe purpose of our study was to identify trends and compare keywords from titles and methods among articles accepted and rejected for publication in the Journal of Dental Education (JDE).MethodsThe titles and abstracts of JDE articles submitted between 2010 and 2020 were extracted. We studied the frequencies of keywords in the title and abstracts and used simple descriptive data to present the information. Additionally, keywords from the methods section from JDE articles reviewed between 2015 and 2020 were analyzed by acceptance versus rejection. University of Michigan Medical School's committee on human subject studies provided an exemption (HUM00196884).ResultsArticles with the terms “knowledge,” “skills,” and “attitudes” appear, separately or together, in the titles of submissions to JDE 510 times during the study period—190 in accepted articles and 320 in rejected articles (an acceptance rate of 37.3%). The term “clinical” is in the title of 337 articles submitted to JDE—195 accepted and 142 rejected (an acceptance rate of 57.9%). However, the term “pre‐clinical” is associated with only 56 articles in the last 10 years—36 accepts and 20 rejects (64.3%). Studies with cross‐sectional study design were accepted at a rate of 72.0% and manuscripts with cohort study designs were accepted at 53.3%. Systematic reviews were accepted at 44.4%, surveys were accepted at 36.7%, meta analyses were accepted at 28%. Questionnaires were accepted at 14%.ConclusionsHigher quality study designs were more likely to be accepted for publication. Studies including a randomizing process and studies that were longitudinal in nature were more likely to be accepted for publication.
Frailty and social participation in older citizens in Japan during the COVID‐19 pandemic
Authors: Ozone Sachiko , Goto Ryhei , Kawada Shogo , Yokoya Shoji 
Published: March 2022

AbstractBackgroundThis study examined the frailty status of older individuals in Japan at 1 year after the onset of the coronavirus disease 2019 (COVID‐19) pandemic based on involvement in social activities before and during the pandemic.MethodsThis cross‐sectional study analyzed citizens aged 65 and 84 who did not require long‐term care in January 2021. A self‐administered questionnaire was mailed to 3000 citizens in Kitaibaraki City, Japan. The questionnaire included social participation status in January 2020 and January 2021, the Kihon Checklist, working status, and economic status. We classified the respondents into the following groups: Nonparticipating, no participation at either time point; Discontinued, participation only in 2020; and Continued, participation at both time points. We compared the Discontinued and Continued groups in terms of Kihon Checklist items using the t‐test.ResultsOf 2963 individuals who received the questionnaire, 1307 (44.1%) returned it, and 1047 were analyzed. Of the respondents analyzed, 586 (56.0%) were in the Nonparticipating group, 254 (24.3%) were in the Discontinued group, and 207 (19.8%) were in the Continued group. On the Kihon Checklist, oral function and mood differed significantly between the Discontinued and Continued groups. The proportion of those with impairment in multiple categories of the Kihon Checklist was 12.3% in the Nonparticipating group, 5.5% in the Discontinued group, and 3.4% in the Continued group.ConclusionsOlder individuals who continued participating in social activities at 1 year into the COVID‐19 pandemic might have a lower risk of frailty in terms of oral function and depressed mood.
Journal of Multicultural Counseling and Development author and article characteristics from 1998 to 2017
Authors: Pesavento Alyssa R. , Muller Lauren A. , Smith Heather L. , Erford Bradley T. , Cobb Nicole A. 
Published: March 2022

AbstractArticles accepted for publication in the Journal of Multicultural Counseling and Development (JMCD) from 1998 to 2017 were reviewed to provide a systematic, quantitative study of journal content by identifying patterns of what is published and who publishes in the JMCD. Trends over time in author characteristics (e.g., number, gender, employment setting, nation of domicile) and article content (e.g., type, topic, design, participant type, sample size, statistical procedures) were analyzed and described.
Comparison of model‐specific histopathology in mouse models of COVID‐19
Authors: Yang Sidi , Cao Liu , Xu Wenting , Xu Tiefeng , Zheng Birong , Ji Yanxi , Huang Siyao , Liu Lihong , Du Jie , Peng Hong , Zhang Huan , Chen Jingdiao , Ke Bixia , Zheng Huanying , Deng Xiaoling , Li Chunmei , Guo Deyin 
Published: March 2022

AbstractA novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has been identified as the causative agent of the current coronavirus disease 2019 pandemic. Development of animal models that parallel the clinical and pathologic features of disease are highly essential to understanding the pathogenesis of SARS‐CoV‐2 infection and the development of therapeutics and prophylactics. Several mouse models that express the human angiotensin converting enzyme 2 (hACE2) have been created, including transgenic and knock‐in strains, and viral vector‐mediated delivery of hACE2. However, the comparative pathology of these mouse models infected with SARS‐CoV‐2 are unknown. Here, we perform systematic comparisons of the mouse models including K18‐hACE2 mice, KI‐hACE2 mice, Ad5‐hACE2 mice and CAG‐hACE2 mice, which revealed differences in the distribution of lesions and the characteristics of pneumonia induced. Based on these observations, the hACE2 mouse models meet different needs of SARS‐CoV‐2 researches. The similarities or differences among the model‐specific pathologies may help in better understanding the pathogenic process of SARS‐CoV‐2 infection and aiding in the development of effective medications and prophylactic treatments for SARS‐CoV‐2.
“Is Omicron mild”? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies
Authors: Rajpal Vijay Rani , Sharma Shashi , Kumar Avinash , Chand Shweta , Joshi Lata , Chandra Atika , Babbar Sadhna , Goel Shailendra , Raina Soom Nath , Shiran Behrouz 
Published: March 2022

AbstractSARS‐CoV‐2 Omicron with its lineages BA.1, BA.2, and BA.3 has triggered a fresh wave of Covid‐19 infections. Though, Omicron has, so far, produced mild symptoms, its genome contains 60 mutations including 37 in the spike protein and 15 in the receptor‐binding domain. Thirteen sites conserved in previous SARS‐CoV‐2 variants carry mutations in Omicron. Many mutations have shown evolution under positive selection. Omicron's giant mutational leap has raised concerns as there are signs of higher virus infectivity rate, pathogenesis, reinfection, and immune evasion. Preliminary studies have reported waning of immunity after two‐dose primary vaccine regime, need for the boosters, folds reduction in vaccine effectiveness and neutralizing antibodies even after boosting and significant neutralization resistance with the therapeutic monoclonal, polyclonal, and convalescent antibodies against Omicron. The narrative that “Omicron is mild,” therefore, needs time to be tested with a deeper, scientific dwelling into the facts.
SARS‐CoV‐2 cold‐chain transmission: Characteristics, risks, and strategies
Authors: Chen Cao , Feng Yenan , Chen Zhixiao , Xia Ying , Zhao Xiang , Wang Ji , Nie Kai , Niu Peihua , Han Jun , Xu Wenbo 
Published: March 2022

AbstractLow temperature and certain humidity are conducive to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for long‐time survival and long‐distance spread during logistics and trades. Contaminated cold‐chain or frozen products and outer packaging act as the carrier of SARS‐CoV‐2, that infects the high‐risk population who works in the ports, cold storage or seafood market. Since the coronavirus disease 2019 (COVID‐19) pandemic worldwide, multiple localized outbreaks caused by SARS‐CoV‐2 contaminated imported cold‐chain products have been reported in China, which brought challenges to COVID‐19 prevention and control. Here, we review the evidences of SARS‐CoV‐2 cold‐chain transmission from six confirmed cold‐chain related COVID‐19 outbreaks in China, especially in terms of SARS‐CoV‐2 whole‐genome sequencing and virus isolation. In addition, we summarize the characteristics and mode of SARS‐CoV‐2 cold‐chain transmission from both six COVID‐19 outbreaks in China and the outbreaks suspected cold‐chain transmission in other countries. Finally, we analyze the underlying risks of SARS‐CoV‐2 cold‐chain transmission and propose the preventive countermeasures.
Thermoresponsive Glycopolypeptide Containing Block Copolymers, Particle Formation, and Lectin Interaction
Authors: Mokrus Mandy , Menzel Henning 
Published: March 2022

AbstractAmphiphilic block copolymers with a thermoresponsive poly(N‐isopropylacrylamide) block and a glycopeptide block are synthesized and particle formation as well as interaction of the glyco‐corona with lectins is investigated. The synthetic route comprises the preparation of block copolymers by N‐carboxyanhydride polymerization and subsequent deprotection to obtain pH‐ and thermoresponsive poly(l‐glutamic acid)‐b‐poly(N‐isopropylacrylamide) (pGA‐b‐pNIPAM), which is then further modified with different amino sugars by a versatile coupling method with 4‐(4,6‐dimethoxy‐1,3,5‐triazin‐2‐yl)‐4‐methylmorpholin‐4‐ium chloride (DMT‐MM). The glycosylated pGA‐b‐pNIPAM block copolymers are investigated with regard to cloud point temperatures (Tcp), particle size, and stability. The morphology of the particles is visualized using cryo‐SEM. Zeta potential measurements are indicating that the saccharide moieties are located on the surface of the particles. This assumption is further substantiated by quantitative lectin interaction assays with nonaggregated and aggregated glycosylated pGA‐b‐pNIPAM. The interaction of the model lectin ConA with the block copolymers is independent of the degree of substitution in the nonaggregated state at room temperature. However, at 37 °C, when particles of pGA‐b‐pNIPAM are present, the interaction becomes stronger with increasing degree of substitution. This interaction with lectins can be used for targeting saccharide‐modified particles in drug delivery.
Je bunter, desto bioaktiver
Authors: Karg Cornelia , Moser Simone 
Published: March 2022

AbstractBeim Chlorophyllabbau entstehen Phyllobiline. Sie galten lange als Abfallprodukte eines Entgiftungsprozesses, zeigen sich aber nun als pharmakologisch aktiv. Diese Pflanzeninhaltsstoffe können wichtig für die Lebensmittelindustrie sein.
Chemiestudium: Fragen stellen, Versuche planen, Variablen kontrollieren
Authors: Ortmann Julia , Graulich Nicole , Vorholzer Andreas 
Published: March 2022

AbstractStudierende lernen nicht, wissenschaftlich zu denken, wenn sie im Laborpraktikum die Versuchsvorschrift einfach nur nacharbeiten. Besser ist es, ihnen vorab Regeln und Strategien für die Arbeitsweisen mitzuteilen, zum Beispiel mit einer digitalen Lernumgebung. Eine solche wurde an der Universität Gießen entwickelt und erprobt.
April, April: Von Gesundheit, Gasen und empfindlichem Gold
Authors: Zbikowski Frauke 
Published: March 2022

AbstractWie Wasserstoff unsere Gesundheit verbessert und unsere Reifen zerstört, warum wir beim Putzen vorsichtig sein sollten und der Trend beim pH‐Wert eindeutig nach oben zeigt.
“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community
Authors: Liu Kevin X. , Hammoudeh Lubna , Haas‐Kogan Daphne A. , Terezakis Stephanie A. 
Published: April 2022

AbstractLittle is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12‐question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40.3%), the prevalence of providing treatment per protocol, but off study, before data are available in abstract or peer‐reviewed form varied from 9.1% (for ACNS1422) to 88.1% (for AHOD1331). Future studies are needed to understand the effects of these practice patterns on outcomes.
Pediatric genitourinary tumors: Distribution, demographics, and outcomes
Authors: Nazemi Azadeh , Daneshmand Siamak , Chang Andy 
Published: March 2022

ABSTRACTImportanceThe diversity of pediatric genitourinary malignancies requires a timely resource detailing tumor characteristics and survival.ObjectiveTo determine the incidence, demographics, and outcomes of all pediatric genitourinary tumors within the United States.MethodsA population‐based search for patients diagnosed with genitourinary cancers under age 15 was performed using the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 registry. Information on primary tumor location, histologic type, patient age, sex, year of diagnosis, race, treatment, cause of death, and survival months was extracted. Descriptive epidemiological and survival statistics were calculated for all variables.ResultsA total of 4576 cases from 1973 through 2015 were identified. The most common primary tumor sites were the kidney (80.3%), testis (12.3%), bladder (2.8%), and vagina (1.5%). Nephroblastoma (87.9%) and sarcoma (3.4%) were the most common renal malignancies. Rhabdomyosarcoma was common in the vagina, bladder, and testis at rates of 66.2%, 61.2%, and 24.6%, respectively. Germ cell tumors (71.0%) were the most common primary tumor of the testis. Ten‐year overall survival (OS) for renal nephroblastoma and sarcoma was 88% and 82%, respectively. Ten‐year OS for RMS of the testis was 91%, the bladder was 79%, the vagina was 79%, and the prostate was 56%. Germ cell tumor 10‐year OS were 96% in the testis and 100% in the vagina.InterpretationA better understanding of the overall distribution and outcomes associated with pediatric genitourinary cancers allows physicians to best understand the patient's disease in the context of current frequency in a genitourinary setting and reported outcomes.
A case of an unfortunate tooth fairy visit to a ventilator‐dependent child
Authors: Be'er Moria , Amirav Israel , Cahal Michal , Rochman Mika , DeRowe Ari , Lavie Moran 
Published: March 2022

AbstractAn 8‐year‐old boy recently sustained a cerebellar arteriovenous malformation rupture, and subsequently suffered from severe neurological injury and became ventilator‐dependent through a tracheostomy. During a routine clinic visit, the parents reported that a loose baby tooth had fallen out and disappeared 7 days earlier. The physical examination was unremarkable, but a chest X‐ray demonstrated a foreign body in the left lung and secondary atelectasis. A rigid bronchoscopy extracted what turned out to be a tooth from the left lower lobe bronchus, with no associated sequelae. Aspiration of a tooth is rare, and it is mostly seen in children and elderly patients following trauma, endotracheal intubation, and dental procedures. Only a few previous studies emphasized the increased risk of foreign body aspiration among neurological impaired children. This unique report describes a child in his physiological exfoliation period, which is characterized by the spontaneous shedding of 20 teeth over the course of several years. In severely neurologically impaired children, this period carries a risk of aspiration of teeth and secondary pulmonary damage. Therefore, treating physicians and caregivers must be aware of this risk, and routine dental check‐ups are advised in a neurological impaired child during this period.
Eosinophilic esophagitis in cystic fibrosis: A case series with long‐term follow‐up
Authors: Mellor Xochitl , Schindler Terri , Saab Shahrazad , Roesch Erica , Sferra Thomas , Sankararaman Senthilkumar 
Published: March 2022

AbstractChallenging mealtime behaviors in young children and difficulties in meeting their dietary intake recommendations are sources of parenting stress and associated with negative quality of life. The gastrointestinal (GI) manifestations of cystic fibrosis (CF) can often present similarly to a GI pathology unrelated to CF. Specifically, this case series focuses on three toddlers with CF who presented with oral aversion and challenging mealtime behaviors and later were diagnosed with eosinophilic esophagitis (EoE). Though EoE often presents with dysphagia, younger patients commonly present with nonspecific GI symptoms such as regurgitation, emesis, abdominal pain, failure to thrive, food intolerance, and oral aversion. Given the overlap of GI manifestations in CF and EoE, it can be challenging for clinicians to diagnose the coexistent EoE in patients with CF. We describe the presenting symptoms, treatment, and successful outcomes of three pediatric patients with CF and EoE. To our knowledge, this is the second case series with a detailed description of EoE in CF.
Iron Catalyzed Cascade Construction of Molybdenum Carbide Heterointerfaces for Understanding Hydrogen Evolution
Authors: Hu Ze‐Nan , Ai Yongjian , Xu Wenjuan , Zhang Xinyue , Sun Zejun , Guo Liutao , Guo Rongxiu , Wang Yao , Ding Kelong , Sun Hong‐bin , Hu Jianshe , Liang Qionglin , Yang Yang 
Published: March 2022

AbstractThe intercrystalline interfaces have been proven vital in heterostructure catalysts. However, it is still challenging to generate specified heterointerfaces and to make clear the mechanism of a reaction on the interface. Herein, this work proposes a strategy of Fe‐catalyzed cascade formation of heterointerfaces for comprehending the hydrogen evolution reaction (HER). In the pure solid‐phase reaction system, Fe catalyzes the in situ conversion of MoO2 to MoC and then Mo2C, and the consecutive formation leaves lavish intercrystalline interfaces of MoO2‐MoC (in Fe‐MoO2/MoC@NC) or MoC‐Mo2C (in Fe‐MoC/β‐Mo2C@NC), which contribute to HER activity. The improved HER activity on the interface leads to further checking of the mechanism with density functional theory calculation. The computation results reveal that the electroreduction (Volmer step) produced H* prefers to be adsorbed on Mo2C; then two pathways are proposed for the HER on the interface of MoC‐Mo2C, including the single‐molecular adsorption pathway (Rideal mechanism) and the bimolecular adsorption pathway (Langmuir–Hinshelwood mechanism). The calculation results further show that the former is favorable, and the reaction on the MoC‐Mo2C heterointerface significantly lowers the energy barriers of the rate‐determining steps.
Group 4 Transition Metal Complexes with Anionic N‐Heterocyclic Olefin Ligands
Authors: Watson Ian C. , Zhou Yuqiao , Ferguson Michael J. , Rivard Eric 
Published: March 2022

AbstractThe synthesis of anionic N‐heterocyclic olefin (aNHO)‐supported Group 4 metal complexes was achieved by salt metathesis reactions between a lithiated aNHO and Group 4 metal tetrahalides. A ligand‐activated bis‐aNHO Zr(II) complex was also obtained and structurally characterized.
The Hazards of Regeneration: From Morgan’s Legacy to Evo-Devo
Authors: Sinigaglia Chiara , Alié Alexandre , Tiozzo Stefano 
Published: March 2022

AbstractIn his prominent book Regeneration (1901), T.H. Morgan’s collected and synthesized theoretical and experimental findings from a diverse array of regenerating animals and plants. Through his endeavor, he introduced a new way to study regeneration and its evolution, setting a conceptual framework that still guides today’s research and that embraces the contemporary evolutionary and developmental approaches.In the first part of the chapter, we summarize Morgan’s major tenets and use it as a narrative thread to advocate interpreting regenerative biology through the theoretical tools provided by evolution and developmental biology, but also to highlight potential caveats resulting from the rapid proliferation of comparative studies and from the expansion of experimental laboratory models. In the second part, we review some experimental evo-devo approaches, highlighting their power and some of their interpretative dangers. Finally, in order to further understand the evolution of regenerative abilities, we portray an adaptive perspective on the evolution of regeneration and suggest a framework for investigating the adaptive nature of regeneration.
Studying Annelida Body Regeneration Under Environmental Stress in Diopatra neapolitana
Authors: Pires Adília 
Published: March 2022

AbstractThe polychaete Diopatra neapolitana is a cosmopolitan annelid that can robustly regenerate both its anterior and posterior body part depending on the position of the amputation. Previous studies demonstrated that body regeneration represents a sensitive and unspecific response to environmental stresses, including contaminants and climate alterations.The posterior body regeneration of D. neapolitana is thus a suitable, ecological and relevant biomarker in ecotoxicological and ecological risk assessment assays. Here we describe the amputation process, the monitoring of the regeneration process of the polychaeteD. neapolitana and the quantification of the impact of environmental stresses on its regenerative capacity.
Studying Xenacoelomorpha WBR Using Isodiametra pulchra
Authors: Egger Bernhard 
Published: March 2022

AbstractXenacoelomorpha are a phylogenetically and biologically interesting, but severely understudied group of worm-like animals. Among them, the acoel Isodiametra pulchra has been shown to be amenable to experimental work, including the study of stem cells and regeneration. The animal is capable of regenerating the posterior part of the body, but not its head. Here, methods such as nucleic acid extractions, in situ hybridisation, RNA interference, antibody and cytochemical stainings, and the general handling of the animals are presented.
Studying Echinodermata Arm Explant Regeneration Using Echinaster sepositus
Authors: Ferrario Cinzia , Ben Khadra Yousra , Sugni Michela , Candia Carnevali M. Daniela , Martinez Pedro , Bonasoro Francesco 
Published: March 2022

AbstractEchinoderms are marine invertebrate deuterostomes known for their amazing regenerative abilities throughout all life stages. Though some species can undergo whole-body regeneration (WBR), others exhibit more restricted regenerative capabilities. Asteroidea (starfish) comprise one of the few echinoderm taxa capable of undergoing WBR. Indeed, some starfish species can restore all tissues and organs not only during larval stages, but also from arm fragments as adults. Arm explants have been used to study cells, tissues and genes involved in starfish regeneration. Here, we describe methods for obtaining and studying regeneration of arm explants in starfish, in particular animal collection and husbandry, preparation of arm explants, regeneration tests, microscopic anatomy techniques (including transmission electron microscopy, TEM) used to analyze the regenerating explant tissues and cells plus a downstream RNA extraction protocol needed for subsequent molecular investigations.
Studying Hemichordata WBR Using Ptychodera flava
Authors: Arimoto Asuka , Tagawa Kuni 
Published: March 2022

AbstractHemichordates are benthic marine invertebrates closely related to chordates. Several species, including Ptychodera flava in the phylum Hemichordates, can undergo whole body regeneration from a small fragment. P. flava is widely distributed in the warm Indo-Pacific region and is easily collected in the lower tidal zone of a shallow beach with a coral reef. Here, we describe the methods for animal collection and preparation of regenerating tissues. The prepared tissues can be used for various molecular and/or histological experiments. We also demonstrate how to examine gene expression patterns in the tissues using whole mount in situ hybridization.