bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructiveness of business interaction in management as a criterion for the effectiveness of organizational leadership
Authors: Komarov V. 
Published: September 2022

The article considers one of the aspects of an integrated approach to assessing the effectiveness of organizational (formal) leadership – the constructiveness of business interaction in management. The author considers the main types of influence in leadership based on the classification of K.Levin and common constructive and destructive models of business behavior (in the typology of S. Covey). The author suggests that following constructive types of influence and models of interaction will help to increase the effectiveness of the leader's influence on followers.
The article describes the author's interpretation of the methods of evaluating the constructiveness of the models of behavior of the head, their generalization into a single comprehensive methodology, the use of which will contribute to the improvement of communications at all levels of interaction in the organization.
The author cites data from studies of constructiveness indicators of almost 500 managers of different levels of management and potential managers from among the personnel reserve. The data obtained allow us to draw conclusions about the main trends of leadership behavior of managers in modern Russian organizations and the importance of constructive business interaction in the formation of an individual leadership style.
The novelty of the research lies in the application of an integrated approach to assessing the effectiveness of organizational leadership; in a broader interpretation of the concept of «leadership style», the dilution of the concepts of «leadership style» and «type of influence in leadership», the allocation of a special factor (characteristic) of leadership that affects the quality of managerial influence – «constructiveness of business interaction».
Kajian Penelusuran Produk Halal Kornet Daging Sapi
Authors: Safitri Amelia , Fahmi Mohammad Zakki , Gunawan Setiyo 
Published: September 2022

Indonesia adalah negara dengan mayoritas penduduk beragama islam. Islam telah mengajarkan bahwa dalam keseharian diwajibkan mengkonsumsi makanan halal. Halal dapat ditentukan melalui beberapa metode, salah satunya dengan metode pendekatan telusur halal atau traceability. Traceability bertujuan untuk melihat asal bahan baku, proses pengolahan hingga produk yang dihasilkan sebagai kriteria mendapatkan sertifikasi halal. Sertifikasi Halal adalah sertifikat yang dikeluarkan oleh Badan Penyelenggara Jaminan Produk Halal yang berguna sebagai informasi dan kenyamanan demi terjaganya produk-produk yang halal utuk dikonsumsi oleh masyarakat sebagai konsumen terutama konsumen yang beragama Islam sesuai dengan Undang-undang Nomor 33 Tahun 2014 Tentang Jaminan Produk Halal. Kornet daging merupakan bahan makanan yang mudah diolah dan sering dikonsumsi oleh masyarakat Indonesia. Kornet daging sapi terdiri atas beberapa merk dengan komposisi yang berbeda-beda dari bahan baku, bahan tambahan hingga bahan penolongnya. Hasil penelusuran diperoleh adanya bahan yang termasuk titik kritis dan non titik kritis baik untuk produk dalam negri maupun luar negri yang telah diakui dan belum diakui oleh Majelis Ulama Indonesia.
Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon
Authors: Veletzky Luzia , Eberhardt Kirsten Alexandra , Hergeth Jennifer , Stelzl Daniel Robert , Zoleko Manego Rella , Mombo-Ngoma Ghyslain , Kreuzmair Ruth , Burger Gerrit , Adegnika Ayôla Akim , Agnandji Selidji Todagbe , Matsiegui Pierre Blaise , Boussinesq Michel , Mordmüller Benjamin , Ramharter Michael 
Published: September 2022

Background
Loiasis–a filarial disease endemic in Central and West Africa–is increasingly recognized as significant individual and public health concern. While the understanding of the disease characteristics remains limited, significant morbidity and excess mortality have been demonstrated. Here, we characterize clinical and hematological findings in a large cohort from Gabon.

Methods
Loiasis-related clinical manifestations and microfilaremia, hemoglobin and differential blood counts were recorded prospectively during a cross-sectional survey. For analysis, participants were categorized into distinct infection states by the diagnostic criteria of eye worm history and microfilaremia.

Results
Analysis of data from 1,232 individuals showed that occurrence of clinical and hematological findings differed significantly between the infection states. Eye worm positivity was associated with a wide range of clinical manifestations while microfilaremia by itself was not. Loa loa infection was associated with presence of eosinophilia and absolute eosinophil counts were associated with extent of microfilaremia (p-adj. = 0.012, ß-estimate:0.17[0.04–0.31]).

Conclusions
Loiasis is a complex disease, causing different disease manifestations in patients from endemic regions. The consequences for the affected individuals or populations as well as the pathophysiological consequences of correlating eosinophilia are largely unknown. High-quality research on loiasis should be fostered to improve patient care and understanding of the disease.
Frailty and risk of cardiovascular disease and mortality
Authors: Liu Xiao , Tou Nien Xiang , Gao Qi , Gwee Xinyi , Wee Shiou Liang , Ng Tze Pin 
Published: September 2022

Background
Prospective cohort studies suggest that frailty is associated with an increased risk of incident cardiovascular disease (CVD) morbidity and mortality, but their mechanistic and developmental relations are not fully understood. We investigated whether frailty predicted an increased risk of incident nonfatal and fatal CVD among community-dwelling older adults.

Methods
A population cohort of 5015 participants aged 55 years and above free of CVD at baseline was followed for up to 10 years. Pre-frailty and frailty were defined as the presence of 1–2 and 3–5 modified Fried criteria (unintentional weight loss, weakness, slow gait speed, exhaustion, and low physical activity), incident CVD events as newly diagnosed registered cases of myocardial infarction (MI), stroke, and CVD-related mortality (ICD 9: 390 to 459 or ICD-10: I00 to I99). Covariate measures included traditional cardio-metabolic and vascular risk factors, medication therapies, Geriatric Depression Scale (GDS), Mini-Mental State Exam (MMSE), and blood biomarkers (haemoglobin, albumin, white blood cell counts and creatinine).

Results
Pre-frailty and frailty were significantly associated with elevated HR = 1.26 (95%CI: 1.02–1.56) and HR = 1.54 (95%CI:1.00–2.35) of overall CVD, adjusted for cardio-metabolic and vascular risk factors and medication therapies, but not after adjustment for GDS depression and MMSE cognitive impairment. The HR of association between frailty status and both CVD mortality and overall mortality, however, remained significantly elevated after full adjustment for depression, cognitive and blood biomarkers.

Conclusion
Frailty was associated with increased risk of CVD morbidity and especially mortality, mediated in parts by traditional cardio-metabolic and vascular risk factors, and co-morbid depression and associated cognitive impairment and chronic inflammation. Given that pre-frailty and frailty are reversible by multi-domain lifestyle and health interventions, there is potential benefits in reducing cardiovascular diseases burden and mortality from interventions targeting pre-frailty and early frailty population.
A meta-analysis of the value of circulating tumor cells in monitoring postoperative recurrence and metastasis of colorectal cancer
Authors: Wu Jiao , Li Zhongyu , Zou Jianhua , Li Liusheng , Cui Ning , Hao Tengteng , Yi Kangjun , Yang Jingyan , Wu Yu 
Published: September 2022

Objective
Circulating tumor cells (CTCs) as novel biomarkers are widely investigated in various cancers, although most of the literature shows that CTCs have predictive value for recurrence, metastasis, and prognosis after CRC surgery, results remain controversial. We aimed to systematically evaluate the value of CTCs in monitoring of colorectal cancer (CRC) recurrence and metastasis after surgery.

Method
The PubMed, Cochrane Library, Embase, and other databases were searched from the establishment of the database to May 27, 2021. Relevant literature searches and data extraction were performed independently by two reviewers. The quality assessment was performed using the QUADAS2 scale developed by the Cochrane collaboration. The heterogeneity was checked using the Spearman correlation coefficient and the Cochran-Q test in the Meta-Disc1.4 software. Subgroup analysis was used to explore the source of heterogeneity. Considering that all the included papers were clinical studies with clinical heterogeneity, random effect model was adopted for analysis. And the sensitivity (Sen), specificity (Spe), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curves of CTCs, in monitoring recurrence and metastasis after CRC, were calculated. The publication bias of the included studies was assessed using Deek’s funnel figure.

Result
The literature included a total of 13 articles, comprising 1788 cases, and the overall quality of the literature was high. After summing up the indicators, the sensitivity pooled-value of the peripheral blood CTCs to monitor the recurrence and metastasis value of CRC after CRC was 0.67 [95%CI (0.62, 0.71)], specificity pooled-value was 0.71 [95%CI (0.67, 0.72)], PLR pooled-value was 2.37 [95%CI [1.52, 3.71]), NLR pooled into 0.53 [95%CI (0.36, 0.78)], DOR pooled into 4.97 [95%CI (2.11, 11.72)], AUC was 0.7395.

Conclusion
Peripheral blood CTCs have a moderate monitoring value for recurrence and metastasis after CRC; CTCs detected one week after surgery may be more correlated with recurrence and metastasis.
Digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children 1–3 years old at a rural facility, Bangladesh: Results from a four arm exploratory study
Authors: Shahid Abu Sadat Mohammad Sayeem Bin , Ahmed Shahnawaz , Renesa Tanzina Tazul , Onni Anindita Tasnim , Dash Sampa , Kishimoto Yuka , Kanahori Sumiko , Ahmed Tahmeed , Faruque Abu Syed Golam , Chisti Mohammod Jobayer 
Published: September 2022

Background
Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children.

Methods
Sixty children of either sex, aged 1–3 years having four groups (healthy children/low dose, healthy children/high dose, children with diarrhea/low dose and children with diarrhea/high dose) were enrolled into this exploratory study between 1st August to 23rd October 2017. Two presumptive doses, low (2.5g) and high (5g), twice daily with 50 ml drinking water for seven days were the interventions. Outcomes were to observe the development of possible abdominal symptoms, such as pain, distension, rumbling, and bloating during the intervention and post-intervention periods in healthy and diarrheal children as well as improvement in stool consistencies in diarrheal children.

Results
Among the diarrheal children, the median (IQR) duration of resolution of diarrhea was 3.9 (2.9, 5.1) days vs. 3.5 (2.0, 8.0) days, p = 0.885; in low dose and high dose groups, respectively. Significant difference was observed in terms of abdominal pain (27% vs. 7%, p = 0.038) and distension (40% vs. 0%, p<0.001) in diarrheal children, compared to healthy children during the pre-intervention period. We also observed significant difference in respect of abdominal distension (23% vs. 0%, p = 0.011), rumbling (27% vs. 0%, p = 0.005) and bloating (43% vs. 3%, p = 0.001) in diarrheal children, compared to healthy children during the intervention period. However, no significant difference was observed in relation to abdominal pain (p = 0.347) and distension (p = 0.165) during the pre-intervention period, compared to the intervention period in diarrheal children. Moreover, no significant difference was observed during the post-intervention period for the diarrheal and healthy children.

Conclusion
Fibersol-2 was found to be well tolerated in healthy and diarrheal children aged 1–3 years.

Trial registration
This study was registered as part of a randomized trial at ClinicalTrials.gov, number NCT03565393. The authors confirmed that all ongoing and related trials for this drug/intervention were registered.
English high-stakes testing and constructing the ‘international’ in Kazakhstan and Mongolia
Authors: Fleming Kara , Shinjee Bolormaa 
Published: September 2022

Abstract
In this paper, we consider the role of high-stakes testing in mediating access to English in two Central Asian contexts where English is increasingly important not just in terms of mobility, but in identity construction on an individual and national level. We argue that in these contexts, English is increasingly constructed not only as a global language but the global language, which also has important implications for determining what counts as an ‘internationalized space’ or ‘internationalized person’, and as part of national strategies intended to make Kazakhstan and Mongolia more international. High-stakes tests like IELTS and TOEFL act as a focal point due to the role of these tests in verifying and ‘converting’ English ability into a quantifiable, transportable figure. We draw on a survey about test-takers’ experiences and practices concerning IELTS and TOEFL as well as interview data about the role and significance of English. Since access to knowledge and preparation for these tests is not evenly distributed across the population, our work provides evidence that some people may be in a more advantageous position to succeed on and benefit from high-stakes testing than others. Previous research on IELTS/TOEFL has largely focused on washback effects on school curriculums, test reliability, and strategies for test preparation, while research on globalization needs to continue to engage with specific mechanisms of how scales and hierarchies are created and maintained. We bridge this gap by considering how success or failure on IELTS/TOEFL becomes internalized as a quality of the individual and a reflection of their abilities, dedication and cosmopolitanism, and how testing contributes to carving out particular ‘international’ spaces. This paper will focus on how English comes to be conflated at least in some cases with being international, and how individuals make sense of high-stakes testing as a way of accessing an ‘international’ scale which may or may not involve literal movement abroad.
Realism, the War in the Ukraine, and the Limits of Diplomacy
Authors: Rösch Felix 
Published: September 2022

AbstractSince the outbreak of the war in the Ukraine, realism has made a comeback in public discourses but it is not clear what realism actually means as it seems to stand for everything: from supporting the Ukraine against Russian aggression to the war is the West’s fault. This is the result of decades of not distinguishing between neorealism and classical realism and implicitly acknowledging neorealist storytelling of having systematized classical realist thought. The present paper is a further intervention to carefully distinguish between both theoretical perspectives to uncover what they can add to current world political problems. It finishes by asking if neorealist scholars like John Mearsheimer have a point that it is the West’s fault and a diplomatic solution needs to be found. They often refer to Hans Morgenthau not least because he was one of the most outspoken critics of the Vietnam War.
Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway
Authors: Mao Yu , Zhang Tiyong 
Published: September 2022

Abstract
Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of GC radioresistance and new radiosensitizers must be revealed and developed to treat GC. Serine hydroxymethyltransferase 2 (SHMT2) is responsible for encoding the mitochondrial form of the pyridoxal phosphate-dependent enzyme. SHMT2 plays a critical role in several types of cancers, while its possible effect on the radiological resistance in GC is still unclear. In this study, we investigated the role of SHMT2 in the radiological resistance of GC. Our data confirmed that SHMT2 was highly expressed in radiation-resistant GC cells. SHMT2 reduced the radiosensitivity of GC cells. In addition, SHMT2 is involved in radiation-induced GC cell apoptosis. Further, SHMT2 regulated the Wnt/β-catenin pathway, therefore reducing the radiosensitivity of GC cells in vivo. In conclusion, we revealed that depletion of SHMT2 enhanced the sensitivity of GC cells to interventional radiotherapy through the Wnt/β-catenin pathway.
Good things come to those who bait: the peroxisomal docking complex
Authors: Rüttermann Maximilian , Gatsogiannis Christos 
Published: September 2022

Abstract
Peroxisomal integrity and function are highly dependent on its membrane and soluble (matrix) components. Matrix enzymes are imported post-translationally in a folded or even oligomeric state, via a still mysterious protein translocation mechanism. They are guided to peroxisomes via the Peroxisomal Targeting Signal (PTS) sequences which are recognized by specific cytosolic receptors, Pex5, Pex7 and Pex9. Subsequently, cargo-loaded receptors bind to the docking complex in an initial step, followed by channel formation, cargo-release, receptor-recycling and -quality control. The docking complexes of different species share Pex14 as their core component but differ in composition and oligomeric state of Pex14. Here we review and highlight the latest insights on the structure and function of the peroxisomal docking complex. We summarize differences between yeast and mammals and then we integrate this knowledge into our current understanding of the import machinery.
Adaptive extragradient methods for solving variational inequalities in real Hilbert spaces
Authors: Thong Duong Viet , Li Xiao-Huan , Dong Qiao-Li , Van Thang Hoang , Van Long Luong 
Published: September 2022

Abstract
The projection technique is a very important method and efficient for solving variational inequality problems. In this study, we developed the subgradient extragradient method for solving pseudomonotone variational inequality in real Hilbert spaces. Our first algorithm requires only computing one projection onto the feasible set per iteration and the strong convergence is proved without the prior knowledge of the Lipschitz constant as well as the sequentially weak continuity of the associated mapping. The second algorithm uses the linesearch procedure such that its convergence does not require the Lipschitz continuous condition of the variational inequality mapping. Finally, some numerical experiments are provided to demonstrate the advantages and efficiency of the proposed methods.
Stability Analysis of Double Diffusive Convection in Local Thermal Non-equilibrium Porous Medium with Internal Heat Source and Reaction Effects
Authors: Noon Najat J. , Haddad Shatha A. 
Published: September 2022

Abstract
The internal heat source and reaction effects on the onset of thermosolutal convection in a local thermal non-equilibrium porous medium are examined, where the temperature of the fluid and the solid skeleton may differ. The linear instability and nonlinear stability theories of Darcy–Brinkman type with fixed boundary condition are carried out where the layer is heated and salted from below. The

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Chebyshev tau technique is used to calculate the associated system of equations subject to the boundary conditions for both theories. Three different types of internal heat source function are considered, the first type increases across the layer, while the second decreases, and the third type heats and cools in a nonuniform way. The effect of different parameters on the Rayleigh number is depicted graphically. Moreover, the results detect that utilizing the internal heat source, reaction, and non-equilibrium have pronounced effects in determining the convection stability and instability thresholds.
Conquering diabetes therapeutic inertia: practical tips for primary care
Authors: Moverley Joy A. , Novak Lucia , Shubrook Jay H. 
Published: September 2022

Abstract
Diabetes is a complex condition that is largely self-managed. Decades of scientific evidence has proved that early glycemic control leads to improved microvascular and macrovascular outcomes in people with diabetes mellitus. Despite well-established management guidelines, only about half of the patients with diabetes achieve glycemic targets, and only one in five patients achieve metabolic control (blood pressure, lipid, and glucose targets), and both patients and physicians find themselves stuck in a rut called therapeutic inertia (TI). The authors present several practical strategies that can be tailored to different practice settings and facilitate reducing TI.
A comparison of the extraction behaviour of tris(2-methylbutyl) phosphate and tri-n-alkyl phosphates for the separation of metal ions for U–Zr and U–Pu–Zr systems by cross-current mode
Authors: Kirubananthan Subashree , Ammath Suresh , Nagarajan Sivaraman 
Published: September 2022

Abstract
Even though, pyroprocessing is considered as a suitable technique for metal fuel processing, attempts are being made in our laboratory to develop a solvent extraction based process as an interim method. Since, the metallic fuels contain considerable amount of Pu(IV) and Zr(IV), the use of conventional extractant tri-n-butyl phosphate (TBP) for reprocessing may pose problems due to third phase formation. In the exploration for the identification of an alternate extractant in the organophosphate family, tris(2-methylbutyl) phosphate (T2MBP), a branched isomer of tri-n-amyl phosphate (TAP) was found to be a potential extractant for nuclear fuel reprocessing. In this context, batch wise extraction and stripping studies with a feed solution containing U(VI) and 6 wt% Zr(IV) were carried out with unirradiated and irradiated 1.1 M solution of T2MBP in n-dodecane (n-DD) and the results were compared with corresponding solutions of TBP and TAP in n-DD. Among all these systems under identical conditions, third phase formation was observed only in the case of irradiated TBP system which makes U–Zr fuel reprocessing difficult using TBP as the extractant. Furthermore, studies have also been carried out with U–Pu–Zr feed solution to understand the extraction and stripping behaviour of these extractants. The stage wise and cumulative percentage of extraction and stripping for each metal ion of these systems were evaluated. Overall, these batch studies indicated that, T2MBP system has comparable extraction and stripping behaviour with U–Zr and U–Pu–Zr feed solutions and T2MBP exhibits better separation factor than TBP.