bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle
Authors: Wang Di , Song Ming , Shen Long-fei , Han Lu , Zhu Ping , Jia Xu , Shang Guo-kai , Cao Yuan , Zhang Wei , Zhong Ming , Wang Zhi-hao 
Published: January 2022

BackgroundPatients suffering from chronic heart failure (CHF) show an increased prevalence of sarcopenia. Levosimendan is an effective drug for the treatment of heart failure, but its effect on sarcopenia is still unclear. We aimed to explore whether levosimendan could enhance skeletal muscle contractibility, improve skeletal muscle atrophy, and thus improve exercise tolerance of individuals with heart failure.MethodsC57BL6/J mice were used to establish the heart failure with sarcopenia model and injected of levosimendan. Mice were separated into control group, sham operation group, HF group, HF + solvent group, HF + levosimendan group, HF + sarcopenia group, HF + sarcopenia + solvent group, HF + sarcopenia + levosimendan group (n = 5–12). After the treatment, exercise capacity and cardiac function were evaluated. Muscle morphology, inflammation level and apoptosis levels were detected, in which mitochondrial function and oxidative stress level were also assessed.ResultLevosimendan could increase forelimb grip strength/body weight, hanging impulse, maximum running distance and time in mice with HF and sarcopenia (P &lt; 0.0001 for all), and these improvements were independent of EF (P = 0.0019 for hanging impulse, P &lt; 0.001 for forelimb grip strength/body weight and maximum running distance). Levosimendan directly increased the CSA of gastrocnemius in mice with HF and sarcopenia (P &lt; 0.0001). After levosimendan injection, the proportion of slow muscle fibers increased (P &lt; 0.0001), but this improvement of muscle fiber typing might be attributed to improved cardiac function (P &gt; 0.05). Levosimendan also maintained mitochondrial membrane potential, decreased cleaved caspase-3 (P = 0.034), cleaved caspase-9 (P &lt; 0.0001), Bax expression (P &lt; 0.0001), and increased Bcl2 expression (P = 0.0036). This effect is independent of improved cardiac function (P = 0.028 for bax, P &lt; 0.001 for cleaved caspase-9 and Bcl2). IL-6, TNF-α expression (P &lt; 0.0001 for both) decreased, and SOD activity (P = 0.0038), GSH/GSSG ratio (P = 0.002) significantly increased in skeletal muscle after injection of levosimendan. The improvement in oxidative stress level was attributed to improved cardiac function (P &gt; 0.05).ConclusionLevosimendan reduce the loss of skeletal muscle mitochondrial membrane potential, decrease the apoptosis, alleviate the inflammation and oxidative stress, and ultimately improve the exercise capacity of mice with heart failure and sarcopenia. Therefore, levosimendan may be a potential drug for the treatment of heart failure with sarcopenia.
Interventions for Perinatal Depression and Anxiety in Fathers: A Mini-Review
Authors: Rodrigues Andre L. , Ericksen Jennifer , Watson Brittany , Gemmill Alan W. , Milgrom Jeannette 
Published: January 2022

Background and ObjectivesUp to 10% of fathers experience perinatal depression, often accompanied by anxiety, with a detrimental impact on the emotional and behavioural development of infants. Yet, few evidence-based interventions specifically for paternal perinatal depression or anxiety exist, and few depressed or anxious fathers engage with support. This mini-review aims to build on the evidence base set by other recent systematic reviews by synthesising more recently available studies on interventions for paternal perinatal depression and anxiety. Secondarily, we also aimed to identify useful information on key implementation strategies, if any, that increase the engagement of men.MethodsWe drew upon three major previous systematic reviews and performed an updated search of PubMed/Medline; Psycinfo; Cochrane Database; Embase and Cinahl. The search was limited to trials, feasibility studies or pilot studies of interventions published between 2015 and 2020 that reported on fathers' perinatal mental health. We included psychological, educational, psychosocial, paternal, couple-focused, or group therapies, delivered face-to-face, via telephone and/or online that reported on either paternal depression, anxiety or both.ResultsEleven studies satisfied search criteria (5 of which were not included in previous reviews). The majority were randomised controlled trials. Most interventions incorporated counselling, therapy or psychoeducation and took an indirect approach to perinatal mental health through antenatal or postnatal education and were couple-focused. No studies reported a presence of diagnosed depression or anxiety at baseline, although five studies reported a positive effect on sub-threshold symptoms.DiscussionThere was some evidence that these approaches may be useful in the initial engagement of fathers with perinatal supports and improve depression and anxiety scores. No studies targeted the explicit treatment of clinically depressed or anxious men, and this remains the most substantial gap in the peer-reviewed evidence base. Our results highlight the need to deliver perinatal interventions specifically designed for men and evaluate them in populations with clinical levels of depressive and anxious symptomatology.
Personality and Peripartum Changes in Perceived Social Support: Findings From Two Prospective-Longitudinal Studies in (Expectant) Mothers and Fathers
Authors: Asselmann Eva , Garthus-Niegel Susan , Martini Julia 
Published: January 2022

ObjectiveThe aim of this study was to examine changes in perceived social support from early pregnancy to 2 years postpartum and to test whether these changes (a) differ between mothers and fathers or (b) vary as a function of the Big Five personality traits.BackgroundHigher peripartum social support in (expectant) mothers and fathers has been associated with fewer complications during pregnancy and delivery as well as better parental and offspring health.MethodsProspective-longitudinal data from two regional-epidemiological samples from Germany were used: MARI (N = 396, including n = 293 mothers and n = 103 fathers) and DREAM (N = 2,819, including n = 1,689 mothers and n = 1,130 fathers). The Big Five personality traits were assessed during pregnancy in MARI as well as 8 weeks after the anticipated birth date in DREAM with short forms of the Big Five Inventory. Perceived social support was assessed during pregnancy, 4 months postpartum, and 16 months postpartum in MARI as well as during pregnancy, 14 months postpartum, and 2 years postpartum in DREAM using the short version of the Social Support Questionnaire.ResultsMultilevel analyses revealed that perceived social support decreased across the peripartum period, and this decrease did not differ between mothers and fathers. More extraverted, emotionally stable, agreeable, conscientious, and open parents perceived higher levels of social support across the peripartum period. The peripartum decrease of perceived social support was smaller in parents who were more extraverted.ConclusionOur findings suggest that especially extraversion plays an important role for high and stable levels of perceived social support across the peripartum period.ImplicationsParticularly highly introverted parents might profit from targeted social support interventions.
Bibliometric Analysis of International Scientific Production on Pharmacologic Treatments for SARS-CoV-2/COVID-19 During 2020
Authors: Ruiz-Fresneda Miguel A. , Jiménez-Contreras Evaristo , Ruiz-Fresneda Carlos , Ruiz-Pérez Rafael 
Published: January 2022

BackgroundCOVID-19 is causing a grave global health and economic crisis and the fight against the pandemic has led to unprecedented scientific activity. Bibliometrics could be a useful tool for guiding future researches lines and promoting international collaboration for an effective treatment. For this purpose, we have conducted a bibliometric analysis of scientific publications on drugs and therapies used to treat COVID-19 during 2020.MethodsData source: Web of Science. We gathered data on scientific production relating to drugs used to treat COVID-19. We calculated impact factors and analyzed production by institution, country, and journal, visualizing our results in bibliometric networks.ResultsIn 1 year, production relating to COVID-19 exceeded 100 000 publications, with over 6,500 on Drugs and COVID-19. Research into hydroxychloroquine and chloroquine, remdesivir, lopinavir and ritonavir, tocilizumab and convalescent plasma is particularly noteworthy. Mean citations/study range from 11.9 to 15.4. Producer institutions fall into three groups: one in the US and centered on Harvard Medical School; another in Europe led by INSERS; and another in China led by Huazhong University of Science and Technology. Production by journal is widespread but the Journal of Medical Virology, International Journal of Antimicrobial Agents, and American Journal of Transplantation are noteworthy.ConclusionsThe volume of research that is currently under way is comparable to the magnitude of the pandemic itself. Such a high volume of studies is infrequent and the impact they have achieved has no known precedent. The producing countries are those with highest incidence of the pandemic and greatest scientific potential; moreover, inter-agency and international collaboration has reached extraordinarily high levels.
Gas-Phase Reactivity of OH Radicals With Ammonia (NH3) and Methylamine (CH3NH2) at Around 22 K
Authors: González Daniel , Ballesteros Bernabé , Canosa André , Albaladejo José , Jiménez Elena 
Published: January 2022

Interstellar molecules containing N atoms, such as ammonia (NH3) and methylamine (CH3NH2), could be potential precursors of amino acids like the simplest one, glycine (NH2CH2COOH). The gas-phase reactivity of these N-bearing species with OH radicals, ubiquitous in the interstellar medium, is not known at temperatures of cold dark molecular clouds. In this work, we present the first kinetic study of these OH-reactions at around 22 K and different gas densities [(3.4–16.7) × 1016 cm−3] in helium. The obtained rate coefficients, with ± 2σ uncertainties, can be included in pure gas-phase or gas-grain astrochemical models to interpret the observed abundances of NH3and CH3NH2. We observed an increase ofk1andk2with respect to those previously measured by others at the lowest temperatures for which rate coefficients are presently available: 230 and 299 K, respectively. This increase is about 380 times for NH3and 20 times for CH3NH2. Although the OH + NH3reaction is included in astrochemical kinetic databases, the recommended temperature dependence fork1is based on kinetic studies at temperatures above 200 K. However, the OH + CH3NH2reaction is not included in astrochemical networks. The observed increase ink1at ca. 22 K does not significantly change the abundance of NH3in a typical cold dark interstellar cloud. However, the inclusion ofk2at ca. 22 K, not considered in astrochemical networks, indicates that the contribution of this destruction route for CH3NH2is not negligible, accounting for 1/3 of the assumed main depletion route (reaction with HCO+) in this IS environment.k1(OH+NH3)=(2.7±0.1)×10−11cm3s-1k2(OH+CH3NH2)=(3.9±0.1)×10−10cm3s-1
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) BERBASIS PROBLEM BASED LEARNING DALAM PEMBELAJARAN MATEMATIKA KELAS IV SEKOLAH DASAR
Authors: Andeswari Septiana , Sholeh Dudung Amir , Zakiyah Linda 
Published: January 2022

This study was conducted to determine the development and feasibility of learning media student worksheets (LKPD) based on Problem Based Learning in learning mathematics for grade IV elementary schools. The research method used in this study is research and development (Research and Development) which uses four stages of the Borg and Gall research and development model, namely: 1) research and information collecting, 2) Planning, 3) develop preliminary form a product, 4) preliminary field testing 5) main product revision, 6) main field testing 7) operational product revision 8) operational field testing, 9) final product revision, 10) desimination. The result of this research and development is a problem based learning LKPD product in the fourth grade elementary school mathematics learning. The feasibility level based on the results of the percentage assessment of material experts, learning media experts, and linguists respectively got 90.47%, 82.28%, and 73.3% with the criteria of "very feasible". Furthermore, the response of students to the product when it was tested in the main field testing stage of the LKPD problem based product also did not require improvement and got a percentage of 95.17% with the criteria of "very good". Based on the results of interviews with fourth grade teachers, teachers are interested in using problem-based learning LKPD products in mathematics learning activities in the classroom. Based on this, it can be concluded that problem-based learning LKPD is appropriate to be used as one of the mathematics teaching materials in geometry learning.
“DESTRUCTION” AND “CREATION” CONCEPTIONS IN GAFUR KULAKHMETOV’S PLAYS
Authors: Шарипова Алсу Самигулловна , Шамсутова Алсу Атласовна 
Published: January 2022

В статье предпринята попытка выявить идейно-эстетические особенности концепций «разрушение» и «созидание» в художественной картине мира татарского драматурга начала ХХ века Гафура Кулахметова. В работе применен герменевтический подход к анализу художественных явлений, а при изучении эпохи и личности драматурга - историко-культурный метод. Исследование выполнено на материале двух пьес Гафура Кулахметова - «Две мысли» и «Молодая жизнь». Изучение художественного воплощения этих концепций производится на основе анализа психологического и аналитического характера монологов и диалогов, метафорических образов, душевного состояния героев. Исследование показало, что проявление в татарской драматургии начала ХХ века сюжетов разрушения - это результат социально-политического влияния. Обнаруженные в тексте пьес Гафура Кулахметова элементы «драматургии масс» послужили для авторов основой для постановки проблемы взаимосвязи и взаимовлияния концепций «нового типа» человека и «разрушения-созидания», что и составляет новизну данного исследования. В ходе работы было выявлено, что художественно-эстетические мотивы «разрушения» и «созидания» являются важными категориями в картине мира татарского народа, носят исторический характер. Драматург в определенной степени призывает серьезно задуматься об их последствиях для продолжения жизни и развития общества. Авторами постулирована возможность расширения изучения концепций «разрушения» и «созидания» в творчестве других татарских писателей начала ХХ столетия.
This article focuses on the ideological and aesthetic features of the concepts “destruction” and “creation” in the Tatar playwright Gafur Kulakhmetov’s works. The authors employed hermeneutic approach to the analysis of literature phenomena, and historical-cultural method for investigation of the epoch and personality of the playwright. The study is performed on the two plays: “Two Thoughts” and “Young Life”. The study of the embodiment of these concepts is based on the analysis of the psychological and analytical monologues and dialogues, metaphorical images, and the psychological state of the characters. The study revealed that the manifestation of the “destruction” concept is the result of socio-political influence. The new elements of “drama for the masses” discovered in Gafur Kulakhmetov’s playsserved the basis for posing the problem of interconnection and mutual influence of the “new type” people concept and antagonism between “destruction” and “creation”, makes the current work relevant The study revealed that the artistic and aesthetic motives of “destruction” and “creation” are important categories in the world picture of the Tatar people. The playwright urges serious reflection on the consequences of destruction for the continuation of life and for the society development. The authors suggest further research onexpanding the study of the concepts “destruction” and “creation” in other Tatar writers’ works at the beginning of the 20th century.
A 20 Second Cadence View of Solar-type Stars and Their Planets with TESS: Asteroseismology of Solar Analogs and a Recharacterization of π Men c
Authors: Huber Daniel , White Timothy R. , Metcalfe Travis S. , Chontos Ashley , Fausnaugh Michael M. , Ho Cynthia S. K. , Van Eylen Vincent , Ball Warrick H. , Basu Sarbani , Bedding Timothy R. , Benomar Othman , Bossini Diego , Breton Sylvain , Buzasi Derek L. , Campante Tiago L. , Chaplin William J. , Christensen-Dalsgaard Jørgen , Cunha Margarida S. , Deal Morgan , García Rafael A. , García Muñoz Antonio , Gehan Charlotte , González-Cuesta Lucía , Jiang Chen , Kayhan Cenk , Kjeldsen Hans , Lundkvist Mia S. , Mathis Stéphane , Mathur Savita , Monteiro Mário J. P. F. G. , Nsamba Benard , Ong Jia Mian Joel , Pakštienė Erika , Serenelli Aldo M. , Silva Aguirre Victor , Stassun Keivan G. , Stello Dennis , Norgaard Stilling Sissel , Lykke Winther Mark , Wu Tao , Barclay Thomas , Daylan Tansu , Günther Maximilian N. , Hermes J. J. , Jenkins Jon M. , Latham David W. , Levine Alan M. , Ricker George R. , Seager Sara , Shporer Avi , Twicken Joseph D. , Vanderspek Roland K. , Winn Joshua N. 
Published: January 2022

Abstract
We present an analysis of the first 20 second cadence light curves obtained by the TESS space telescope during its extended mission. We find improved precision of 20 second data compared to 2 minute data for bright stars when binned to the same cadence (≈10%–25% better for T ≲ 8 mag, reaching equal precision at T ≈ 13 mag), consistent with pre-flight expectations based on differences in cosmic-ray mitigation algorithms. We present two results enabled by this improvement. First, we use 20 second data to detect oscillations in three solar analogs (γ Pav, ζ Tuc, and π Men) and use asteroseismology to measure their radii, masses, densities, and ages to ≈1%, ≈3%, ≈1%, and ≈20% respectively, including systematic errors. Combining our asteroseismic ages with chromospheric activity measurements, we find evidence that the spread in the activity–age relation is linked to stellar mass and thus the depth of the convection zone. Second, we combine 20 second data and published radial velocities to recharacterize π Men c, which is now the closest transiting exoplanet for which detailed asteroseismology of the host star is possible. We show that π Men c is located at the upper edge of the planet radius valley for its orbital period, confirming that it has likely retained a volatile atmosphere and that the “asteroseismic radius valley” remains devoid of planets. Our analysis favors a low eccentricity for π Men c (<0.1 at 68% confidence), suggesting efficient tidal dissipation (Q/k
2,1 ≲ 2400) if it formed via high-eccentricity migration. Combined, these early results demonstrate the strong potential of TESS 20 second cadence data for stellar astrophysics and exoplanet science.
The Impact of Serious Game on the Nursing Students' Learning, Behavioral Engagement, and Motivation
Authors: EL Machtani EL Idrissi Wissam , Chemsi Ghizlane , EL Kababi Khadija , Radid Mohamed 
Published: January 2022

Digital game-based learning is a ludic approach that has evolved through the development of information and communication technologies (ICT), making the learner an active participant in the virtual learning environment instead of a mere observer. It is an electronic simulation tool suitable for improving learning efficiency as well as learner engagement and motivation. The integration of this educational technology in the teaching and learning process can contribute to the construction of knowledge, the development of new skills and attitudes among students.
The purpose of this study is to investigate the impact of serious game on the learning, behavioral engagement, and motivation of nursing students. To do this, we first conducted a study with a sample of 58 polyvalent nursing students divided into two groups; one experimental and the other as a control. Both groups benefited from the same content taught at a distance, however, the experimental group benefited from an online serious game after the course. By comparing the summative scores of the two groups using the Student's t-test, the results show that the serious game improved the students' clinical knowledge of pediatric nursing (t= -2.706,p=0.009). However, it did not have an effect on clinical skills (t= -0.373, p=0.711). As a second step, we have studied the impact of the game on the learners' behavioral engagement based on the analysis of the digital traces of the students' work. Meanwhile, the motivation is analyzed using a questionnaire developed from the ARCS scale of Killer (2010), which is distributed to the experimental group. By comparing the means and deviation standards, the results show that the students give the satisfaction factor the highest score (4.71±0.34) followed by the relevance, attention, and confidence factors.
To obtain reliable results, however, it is necessary to repeat the serious game experience in several nursing modules. In addition, the impact of combining serious game with simulation on the learning of nursing students should be studied.
Coping, Social Support, and Caregiver Well-Being With Families Living With SCI: A Mixed Methods Study
Authors: Ryerson Espino Susan L. , O’Rourke Kerry , Kelly Erin H. , January Alicia M. , Vogel Lawrence C. 
Published: January 2022

Objectives:
To explore coping, problem solving, social support, and well-being among family caregivers of adults with spinal cord injury (SCI).

Methods:
This was a mixed methods study (qualitative interviews and standardized surveys) with a diverse sample of 39 adults with SCI and their caregivers from four rehabilitation hospitals in the United States, including one Veterans Affairs (VA) hospital. Cluster analysis was used to explore whether distinct profiles of caregivers could be identified, and it was used in conjunction with qualitative data to explore patterns in well-being. Measures of well-being included leisure time satisfaction, social integration, anxiety, depression, physical health complaints, caregiver burden, and quality of life.

Results:
The importance of individual and extra-individual resources, namely coping and social support, emerged from early qualitative analyses and guided subsequent mixed methods examination of the data. A cluster analysis yielded three caregiver profiles: (1) effective problem solvers with moderate satisfaction with social support, (2) mixed problem solvers with stronger negative orientations and mixed satisfaction with social support, and (3) low endorsers overall. Profiles helped us explore patterns across our data set and efficiently identify differences in caregiver social support, coping, well-being, and unmet needs.

Conclusion:
Data echo the need for multimodal interventions aimed at skill development, respite options, and screening, support, information, and referral around mental health and burden. SCI care and rehabilitation programs should consider incorporating strategies for bolstering effective caregiver problem-solving skills, reducing negativity and ambivalence, and enhancing social support.