bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Link between Serum Omentin Level and Insulin Resistance Biomarkers, Lipid Profile, and Atherogenic Indices in Iraqi Obese Patients.
Authors: Kadium Tahrir Etihad , Alrubaie Abdulhadi , Ghanim Salim Abd Mohammed 
Published: July 2022

Omentin (or intelectin) is a main visceral fat secretory adipokine. There is a growing interest to link omentin, obesity and co-morbidity factors. The aim of the present study is to evaluate serum omentin and its association to insulin resistance biomarkers, lipid profile and atherogenic indies. This cross – sectional study was conducted in Obesity Research and Therapy Unit-Alkindy College of Medicine by recruiting (115) individuals; 49 males /66 females. Subjects between (20 to 60) years of age were selected and classified into two groups according to their Body mass index (BMI). Group1 involved healthy lean volunteers (25 male/ 36 female; BMI 18.5 - 24.9). Group2 involved obese subjects; (24 male / 36 female with BMI ≥ 30). The study shows that obese group has higher omentin levels compared to the healthy lean group (15.49 ± 4.20 vs. 10.15 ± 5.04 pg/ml, P <0.001). In addition; obese group exhibited significantly higher levels waist circumference (WC), waist to hip ratio (WHR), glucose, insulin, homeostatic module of insulin resistance (HOMA2-IR) and lipid profile and lower levels of HDL-Chol (P <0.05). Omentin levels were significantly and positively correlated with WC, WHR, BMI, glucose, hemoglobin A1c, HOMA2-IR, triglyceride, total cholesterol, low density lipoproteins - cholesterol, triglyceride to glucose index (TyG index) and atherogenic index of plasma (AIP); (P< 0.05). Multiple regression analysis established that omentin levels was found to be associated with glucose, total Chol, TyG index and AIP in total population. These findings indicate that serum omentin levels are higher in obese individuals compared to lean subjects. Furthermore, omentin was linked to insulin resistance biomarkers and other risk factors indices such as AIP and TyG. Omentin can be used as a metabolic marker in obese.
A novel target for cancer therapy on the RNA stimulation by FUBP1- interacting repressor (FIR) via TFIIH/P62
Authors: Kitamura Kouichi , Hoshino Tyuji , Okabe Atsushi , Fukuyo Masaki , Rahmutulla Bahityar , Tanaka Nobuko , Kobayashi Sohei , Tanaka Tomoaki , Shida Takashi , Ueda Mashiro , Minamoto Toshinari , Matsubara Hisahiro , Kaneda Atsushi , Matsushita Kazuyuki 
Published: July 2022

Abstract
This study indicated the novel impaired mechanism of ribosomal RNA (rRNA) transcription that causes cancer development. Human transcription factor IIH (TFIIH) is an essential factor with a seven-subunit core, including the P62 subunit, and is pivotal for DNA repair and transcription. Three RNA polymerases (RNAPs), RNAPI, II and III, possess a common RPB6 subunit that interacts with P62 of TFIIH. The FUBP1-interacting repressor (FIR) is a transcriptional suppressor of c-myc via suppressing DNA helicase activity of TFIIH. This study showed that FIR contains a highly conserved acidic string region, like the region of the RPB6 subunit of RNAPI. Knockdown of FIR by siRNA suppressed P62 expression in vivo in cancer cells. The isothermal titration calorimetry (ITC) measurements revealed the molecular interaction between the authentic FIR rather than FIRΔexon2, a dominant-negative splicing form of FIR that lacks the transcriptional repression domain exon2, and P62. Furthermore, knockdown of FIR and FIRΔexon2 by siRNA led to dynamic changes in ribosomal RNA (rRNA) expression assessed by RNA-seq analysis. A qRT-PCR analysis confirmed that FIR and FIRΔexon2 significantly changed the expression of numerous rRNAs on specific chromosomes. Moreover, small molecular chemical compounds against FIR and FIRΔexon2 were screened among 23,275 chemicals by Natural Product Depository (NPDepo) Array at RIKEN (Japan). Among them, BK697 that potentially binds FIR and FIRΔexon2 significantly inhibited tumor cell growth with the suppression of ribosomal proteins, FIR, and FIRΔexon2 expression. In summary, FIR and FIRΔexon2 provide a novel insight into cell proliferation by stimulating dynamic ribosome biosynthesis and a hint of therapeutic strategy.
A partially block randomized extended Kaczmarzmethod for solving large overdetermined insistentlinear systems
Authors: Zhang Bu-Yue , Huang Guang-Xin 
Published: July 2022

Abstract
This paper presents a partial block random extended Kaczmarz (PBREK) method for solving large overdetermined inconsistent linear system of equations $Ax=b$. It is proved that the proposed PBREK method converges to the least squares solution of $Ax=b$. Several examples are given to show the effectiveness of the proposed PBREK method, and it is compared with the PREK algorithm.
Sexual function index adaptation for breast cancer patients (FSFI-BC)- Translation and Psychometric properties of Iranian version
Authors: Masjoudi Marzieh , Keshavarz Zohre , Akbari Mohammad Esmaeil , Kashani Farah Lotfi , Nasiri malihe , Mirzaei Hamidreza 
Published: July 2022

Abstract
Background- Effective interventions to improve sexual dysfunction in breast cancer survivors need screening of these dysfunctions with a suitable instrument. The aim of present study was translation and identifying psychometric properties of FSFI-BC which has been specifically developed for breast cancer survivors. Method-Forward and backward method was used for translating of the scale from English into Persian. 200 breast cancer survivors in stage 1 or 2 completed the questionnaire. Reliability was assessed by Cronbach’s alfa and test re-test analysis and construct validity with confirmatory and exploratory factor analysis.Results-The mean age of participants was 48.91(SD=9.758). Most women were housewives (74%) and mastectomy had been performed for 58% of them. Reliability evaluation indicated high internal consistency and good test re-test reliability. Confirmatory factor analysis showed an acceptable fitness for seven factor of FSFI-BC questionnaire (NFI= 0.9 for both groups, CFI= 0.93 and 0.92 , χ2/df= 1.68 and 1.71 for SA(Sexually Active) and NSA(No Sexually Active) individuals respectively) .Conclusion-Study findings suggest that Iranian version of FSFI-BC is a suitable instrument for sexual dysfunction screening in breast cancer survivors.
Feasibility and Safety of a Novel 3D-Printed Biodegradable Biliary Stent in an In Vivo Porcine Model: A Preliminary Study
Authors: Kim Jae Hyun , Ha Dong-Heon , Han Eui Soo , Choi YoungRok , Koh Jiwon , Joo Ijin , Kim Jeong Hoon , Cho Dong-Woo , Han Joon Koo 
Published: July 2022

Abstract
Purpose
To assess the feasibility and safety of a novel 3D-printed biodegradable biliary stent using polycaprolactone (PCL) in an in vivo porcine model
Materials and Methods
In this animal study using domestic pigs, biodegradable radiopaque biliary stents made of polycaprolactone (PCL) and barium sulfate were produced using 3D printing and surgically inserted into the common bile duct (CBD) of pigs (stent group, n = 12). Another five pigs were allocated to the control group that only underwent resection and anastomosis of the CBD without stent insertion. To check the position and status of the stents and stent-related complications, follow-up computed tomography (CT) was performed every month. The pigs were sacrificed 1 or 3 months after surgery, and their excised CBD specimens were examined at both the macroscopic and microscopic levels.
Results
Three pigs (one in the stent group and two in the control group) died within one day after surgery and were excluded from further analysis; the remaining 11 in the stent group and 3 in the control group survived the scheduled follow-up period (1 month, 5 and 1; and 3 months, 6 and 2 in stent and control groups, respectively). In all pigs, no clinical symptoms or radiologic evidence of biliary complications was observed. In the stent group (n = 11), stent migration (n = 1 at 3 months; n = 2 at 1 month) and stent fracture (n = 3 at 2 months) were detected on CT scans. Macroscopic evaluation of the stent indicated no significant change at 1 month (n = 3) or fragmentation with discoloration at 3 months (n = 5). On microscopic examination of CBD specimens, the tissue inflammation score was significantly higher in the stent group than in the control group (mean ± standard deviation (SD), 5.63 ± 2.07 vs. 2.00 ± 1.73; P = 0.039) and thickness of fibrosis of the CBD wall was significantly higher than that of the control group (0.46 ± 0.12 mm vs. 0.21 ± 0.05mm; P = 0.012).
Conclusion
Despite mild bile duct inflammation and fibrosis, 3D-printed biodegradable biliary stents showed good feasibility and safety in porcine bile ducts, suggesting their potential for use in the prevention of postoperative biliary strictures.
Study the Removal Efficiency of Chromium Ions Using Membrane by Electro _ Kinetic Technique from Sludge
Authors: Hadi Nabaa S. , Awadh Huda H. 
Published: July 2022

Abstract
In recent years, eletrokinetic (EK) remediation has become more popular as a novel method for removing chromium contamination from soil. This approach, however, is ineffective since it uses both cationic and anionic forms of chromium. In this work, a membrane-based technique was employed to increase the efficiency of eletrokinetic removal of chromium. Chromium removal from polluted sludge was studied in four bench-scale experiments, two of which have used a distilled water (EK-1, EK2&Membrane) and two of which have used acetic acid as a catholyte (EK-3, EK4&Membrane). The pH, total chromium, and fractionation of chromium in the sludge were measured after remediation. In the EK-1, EK-2&Membrane and EK-3, EK-4&Membrane trials, the average removal efficiency of total chromium was 47.6%, 58.6%, and 74.4%, 79.6%, respectively. In contrast to the eletrokinetic remediation strategy, which left around 80% of the sludge neutral or alkaline after treatment, the use of Membrane created acidic soil conditions throughout the sludge. For example, the high field intensity used in the Membrane tests may have helped to facilitate chromium desorption, dissolution and separation from the sludge, as well as enhancing chromium mobility. The findings show that Membrane can improve the effectiveness of chromium removal from sludge when utilized in the EK remediation process.
Respiratory Health Study: Pulmonary Infection Screening Using Wearable Sensor Data
Authors: Xie Lixin , Chen Yibing , She Danyang , Guo Yutao , Chen Wenjuan , Li Jing , Li Dan 
Published: July 2022

Abstract
BackgroundThe proliferation of smart devices provides the possibility of the early detection of the signs of pulmonary infection. This study validates a smart device-based algorithm to monitor the risk of pulmonary infection.MethodsAn algorithm that runs on Huawei smart devices (Huawei Technologies Co., Ltd., Shenzhen, China) was developed and tested in 87 patients with pulmonary infection and 409 healthy subjects. The algorithm examines heart rate variability, respiratory rate, oxygen saturation, body temperature, and cough sound. It was embedded into the Respiratory Health Study app for a smartwatch to detect the risk of pulmonary infection and was further validated in the hospital. Pulmonary infection was diagnosed by doctors using a clinical evaluation, lab tests, and imaging examination, the gold standard for diagnosis. The accuracy, sensitivity, and specificity of the algorithm predicting pulmonary infection were evaluated.ResultsIn all, 80 patients with pulmonary infections and 85 healthy volunteers were recruited to validate the accuracy of the algorithm. The area under the curve of the algorithm for predicting pulmonary infection was 0.86 (95% confidence interval: 0.82–0.91) (P < 0.001). Compared to the gold standard, the overall accuracy of the algorithm was 85.9%, the sensitivity was 81.4%, and the specificity was 90.4%. The algorithm for heart rate, respiratory rate, oxygen saturation, and body temperature had an accuracy of 68.2%, and the accuracy of the algorithm including cough sound was 82.6%.ConclusionOur wearable system facilitated the detection of risk of pulmonary infection. Multi-source features were useful for enhancing the performance of the lung infection screening algorithm.Trial RegistrationChinese Clinical Trial Registry of the International Clinical Trials Registry Platform of the World Health Organization ChiCTR2100050843; http://www.chictr.org.cn/showprojen.aspx?proj=126556
Modification of Subgrade material in Sohar university’s campus in Oman based on Subbase and base materials’ specifications
Authors: Ibrahim Osama Ragab , Gamil Yara , Maghawry Salma Al , Sheikh Ruqaya Al 
Published: July 2022

Abstract
Flexible pavements consist of four main layers: subgrade, subbase, base, and surface layer. The surface layer is the impermeable layer of the pavement since it contains bitumen. The area the load is distributed over gradually increases in the Base, subbase, and subgrade layers. Subgrade layer is what represents the main foundation that supports the entire basement structure. Flexible pavements must have sufficient strength and stiffness to be able to withstand the subjected high stresses resulting from the applied wheel loads. the pavement layers materials are evaluated based on the soil classification and graduation, and the California bearing ratio. Generally, the main difference between subgrade soil and some beys and based soil is that the upper layers have more strict specifications since they are subjected to lower stress. As a result, if the existing subgrade soil is of sufficient strength, it could be modified in a way that increases its strength and makes it suitable to be used as subbase and base layers. This study aims to evaluate the subgrade soil existing in Sohar university campus and apply suitable modifications to create enhanced soil that is suitable to be used in the upper layers of the pavement. Such modifications are economically beneficial since it gives the opportunity of only having to transport the extra material instead of transporting the entire amount used for constructing the pavement leading to a significant reduction in the construction cost which is the main cost of the construction of the flexible pavement.
Influence of obesity and fluid restriction on operative outcomes in hepatic resection
Authors: Suh Suk-Won 
Published: July 2022

Abstract
Background
The number of obese patients requiring hepatic resection is increasing. However, little is known about operative outcomes in such patients.
Methods
A total of 175 patients who underwent hepatic resection between March 2015 and July 2021 were evaluated. The patients were divided into two groups according to their body mass index (BMI) using the World Health Organization definition of obesity for Asians: obese patients (BMI ≥ 25 kg/m2, n = 84) and non-obese patients (BMI < 25 kg/m2, n = 91).
Results
Diabetes mellitus (P = 0.004) and hypertension (P = 0.001) were more common in the obese patients than in the non-obese patients. The operative duration (195.7 ± 62.9 min vs. 176.0 ± 53.6 min, P = 0.027) was longer and related to a higher estimated blood loss (EBL) ≥ 500 mL (61.9% vs. 40.7%, P = 0.005) in the obese patients than in the non-obese patients. Obesity (odds ratio [OR], 2.204; 95% confidence interval [CI], 1.177–4.129; P = 0.014) and central venous pressure (CVP) ≥ 5 (OR, 2.733; 95% CI, 1.445–5.170; P = 0.002) at the start of the surgery were significant risk factors for EBL ≥ 500 mL. Obese patients with low CVP showed significantly lower EBL than those with high CVP but a similar EBL to non-obese patients (P = 0.003).
Conclusion
Fluid restriction for lowering CVP should be considered for minimizing blood loss during hepatic resection in obese patients.
Analysis of clinical characteristics of neonatal subcutaneous gangrene
Authors: Wu Fang , Wang Yi , Liu Wei , Guo Zhenhua 
Published: July 2022

Abstract
Purpose: To analyze the clinical characteristics of neonatal subcutaneous gangrene (NSG) and explore the management.Methods: From January 2000 to December 2021, 88 neonates treated for NSG at the Children's Hospital of Chongqing Medical University were included in our study. Results: 83 underwent multi-incision and drainage, 85 were cured, and 3 died. Newborns with full-term and full-weight were more likely to suffer from NSG. The common age of morbidity of NSG was 5-10 days after birth, and the lesion sites were often located in the back (31.82%), sacral buttocks (30.68%), head and neck (31.82%). The median area of lesion was 56cm2. The rate of pus culture in our study was 88.64% and the positive rate was 88.46%, of which 65 cases were detected with Staphylococcus aureus. The rate of blood culture was 69.32%, and the positive rate was 8.20%, and the culture results were all Gram-positive coccus. NSG was prone to complicate with hypoproteinemia, neonatal pneumonia, and neonatal sepsis. Prolonged preoperative anti-infective therapy was not effective in reducing the complications of NSG and the length of stay.Conclusion: Early diagnosis and timely multi-incision and drainage combined with intravenous antibiotics were the key to improve the cure rate of NSG.
Reliability of the Heartbeat Tracking Task to Assess Interoception
Authors: Santos Lucas Eduardo Rodrigues , Elsangedy Hassan Mohamed , de Souza Catarina Fernanda Costa Xavier Monteiro , Mesquita Bruna Milene da Silva , Brietzke Cayque , Vinícius Ítalo , Pereira Daniel Carvalho , Pires Flávio Oliveira , Santos Tony Meireles 
Published: July 2022

Abstract
Interoception refers to the competence in perceiving and interpreting internal sensations emerging from the body. The most common approach to assess interoception is through cardiac interoceptive tests like the heartbeat tracking task (HTT), which measures the accuracy on perceive and counting heartbeats during a period. However, the literature is scarce in providing adequate reliability evidence for this measure so that the interoception assessment may be threaten. In addition to HTT accuracy, it is possible to determine sensibility (self-reported confidence) and interoceptive awareness (correspondence between accuracy and sensibility). Thus, we measured the test-retest reliability of HTT and also investigated the behavior of HTT outcomes along the task. Therefore, 31 healthy adults (16 males) with 27.8 (9.4) years old performed two consecutive HTT interspersed by one day. Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and minimal detectable difference (MD) analyzes showed 'Good' relative reliability for interoceptive accuracy (ICC = 0.880; SEM = 0.263; MD = 0.728; p < 0.001) and 'Moderate' for sensibility (ICC = 0.617; SEM = 0.648; MD = 1.797; p < 0.001) and awareness (ICC = 0.593; SEM = 0.227; MD = 0.628; p < 0.001). The absolute reliability shows low threshold values for observing true effects in HTT outcomes. The results also showed that reducing the number of HTT blocks did not impact the outcomes. The HTT showed to be reliable in determine the interoceptive competences in healthy adults.
Discriminating seismic events using 1D and 2D CNNs: applications to volcanic and tectonic datasets
Authors: Nakano Masaru , Sugiyama Daisuke 
Published: July 2022

Abstract
Detecting seismic events, discriminating between different event types, and picking P- and S-wave arrival times are fundamental but laborious tasks in seismology. In response to the ever-increasing volume of seismic observational data, machine learning (ML) methods have been applied to try to resolve these issues. Although it is straightforward to input standard (time-domain) seismic waveforms into ML models, many studies have used time–frequency-domain representations because the frequency components may be effective for discriminating events. However, detailed comparisons of the performances of these two methods are lacking. In this study, we compared the performances of 1D and 2D convolutional neural networks (CNNs) in discriminating events in datasets from two different tectonic settings: tectonic tremor and ordinary earthquakes observed at the Nankai trough, and eruption signals and other volcanic earthquakes at Sakurajima volcano. We found that the 1D and 2D CNNs performed similarly in these applications. Half of the misclassified events were misassigned the same labels in both CNNs, implying that the CNNs learned similar features inherent to the input signals and thus misclassified them similarly. Because the first convolutional layer of a 1D CNN applies a set of finite impulse response (FIR) filters to the input seismograms, these filters are thought to extract signals effective for discriminating events in the first step. Therefore, because our application was the discrimination of signals dominated by low- and high-frequency components, we tested which frequency components were effective for signal discriminations based on the filter responses alone. We found that the FIR filters comprised high-pass and low-pass filters with cutoff frequencies around 7–9 Hz, frequencies at which the magnitude relations of the input signal classes change. This difference in the power of high- and low-frequency components proved essential for correct signal classifications in our dataset.
Improved Antibiotic Activity from Streptomyces monomycini strain RVE129 Using Classical and Statistical Design of Experiments
Authors: Elias Firew , Muddada Sudhamani , Muleta Diriba , Tefera Belachew 
Published: July 2022

Abstract
Streptomyces sp. has provided a wealth of bioactive secondary metabolites with interesting antimicrobial, antiviral, and anticancer activities. This study aimed to optimize antibiotic production medium and growth conditions of Streptomyces monomycini RVE129 isolated from rhizospher soil of Hawassa, Ethiopia, under shaking conditions by traditional and statistical methods. The classical one-factor-at-a-time (OFAT) approach and the statistical Plackett Burman (PB) design was used for the selection of the important media components; which were further optimized and identify their concentrations using Box-Behnken design for improved antibiotic production by Streptomyces monomycini RVE129. The antibacterial activity of obtained antibiotics by the strain in flask cultures was tested using the disc diffusion method with S. aureus as the test organism, and cell growth was measured as the weight of dry cells in a constant volume of culture broth. Streptomyces monomycini strain RVE129 was able to produce maximum antibiotics on a modified ISP4 medium consisting of 10 gL− 1 starch 4 gL− 1 yeast extract 1 gL− 1 NaCl, 1 gL− 1 MgSO4.7H2O, 2 gL− 1 (NH4)2SO4, and 1 gL− 1 K2HPO4 in comparison to other tested media. The most efficient sources of carbon and nitrogen for the S. monomycini RVE129 strain were determined to be starch and soya bean meal. The optimum conditions for antibiotic production were observed at a temperature of 30°C and a pH of 7.5 on the 8th day of incubation under shaking conditions. Subsequently, media components such as soy bean meal, starch, and K2HPO4 were recognised as the most significantly affecting antibiotic production with a confidence level of above 95% by Plackett-Burman design. Further optimization of the concentration of three media factors by Box-Behnken (BB) design–RSM revealed optimal values of starch- 20 gL− 1, soybean meal- 7.5 gL− 1, and K2HPO4 1.25 gL− 1 and there was nearly 21% increase in the yield of antibiotic production (35.67 mm) when compared to unoptimized medium (27 mm). Antibiotic yield was improved by optimizing the medium and culture conditions. To our knowledge, this is the first study on medium optimization for antibiotic production by Streptomyces monomycini RVE129.