bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting mortality in acute kidney injury patients undergoing continuous renal replacement therapy using a visualization model: A retrospective study
Authors: Zeng Zhenguo , Zou Kang , Qing Chen , Wang Jiao , Tang Yunliang 
Published: November 2022

Background: Patients with severe acute kidney injury (AKI) require continuous renal replacement therapy (CRRT) when hemodynamically unstable. We aimed to identify prognostic factors and develop a nomogram that could predict mortality in patients with AKI undergoing CRRT.Methods: Data were extracted from the Dryad Digital Repository. We enrolled 1,002 participants and grouped them randomly into training (n = 670) and verification (n = 332) datasets based on a 2:1 proportion. Based on Cox proportional modeling of the training set, we created a web-based dynamic nomogram to estimate all-cause mortality.Results: The model incorporated phosphate, Charlson comorbidity index, body mass index, mean arterial pressure, levels of creatinine and albumin, and sequential organ failure assessment scores as independent predictive indicators. Model calibration and discrimination were satisfactory. In the training dataset, the area under the curves (AUCs) for estimating the 28-, 56-, and 84-day all-cause mortality were 0.779, 0.780, and 0.787, respectively. The model exhibited excellent calibration and discrimination in the validation dataset, with AUC values of 0.791, 0.778, and 0.806 for estimating 28-, 56-, and 84-day all-cause mortality, respectively. The calibration curves exhibited the consistency of the model between the two cohorts. To visualize the results, we created a web-based calculator.Conclusion: We created a web-based calculator for assessing fatality risk in patients with AKI receiving CRRT, which may help rationalize clinical decision-making and personalized therapy.
Sleep disturbance and quality of life among university freshmen in Qinghai–Tibet Plateau of China
Authors: Zhang Tiantian , Lu Li , Ren Yan-Ming , Liu Yu-Ying , Hynek Kamila Angelika , Gao Jie , Chen Hong-Ru , Shen Hong-Yi , Gai Xiang-Yun , Dang Zhan-Cui , Liu Shou 
Published: November 2022

PurposeUniversity freshmen are particularly vulnerable as they are undergoing the transition from high school to university with a range of changes. Sleep problems among this group in the Qinghai–Tibet Plateau of China were barely studied. This study aimed to explore sleep disturbance, and its association with quality of life (QoL) and demographic and clinical characteristics among university freshmen in Qinghai–Tibet Plateau, China.MethodsA multistage stratified cluster random sampling method was performed to recruit student participants with a structured questionnaire to collect sociodemographic and clinical characteristics, and lifestyle behaviors. Sleep disturbance including three aspects of sleep disturbance (i.e., difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), and early morning awakening (EMA)) was assessed using standardized measurement. Multiple logistic regression models were applied to analyze the data.ResultsAmong included 2,769 freshmen, the prevalence of sleep disturbance was 14.8% (95% CI: 14.2–15.5%), and corresponding prevalence of DIS, DMS, and EMA was 8.2% (95% CI: 7.7–8.7%), 8.3% (95% CI: 7.8–8.8%), and 4.2% (95% CI: 3.8–4.6%), respectively. Freshmen with sleeping disturbance had significantly lower QoL in physical [F(1, 2769) = 60.23, p &lt; 0.001], psychological [F(1, 2769) = 46.18, p &lt; 0.001], social [F(1, 2769) = 23.04, p &lt; 0.001], and environment [F(1, 2769) = 6.07, p = 0.01] domains. Multiple logistic regression analyses revealed that having breakfast five times a week or less (less than three times, OR = 1.79, 95% CI: 1.34–2.40; 3–5 times, OR = 1.40, 95% CI: 1.09–1.79), self-perceived severe Internet dependence (OR = 1.71, 95% CI: 1.11–2.65), self-perceived poor health status (OR = 3.44, 95% CI: 2.06–5.74), high academic stress (OR = 1.42, 95% CI: 1.13–1.78), poor relationship with classmates (OR = 3.44, 95% CI: 1.53–7.71), and severe ADHD symptoms (OR = 1.08, 95% CI: 1.05–1.12) were positively associated with sleeping disturbance.ConclusionSleep disturbance was common among freshmen and is associated with poorer QoL. Prevention and intervention strategies should be developed and implemented, especially among the vulnerable university freshman groups.
Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: A Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation
Authors: Kruszewski Marek , Aksenov Maksim Olegovich 
Published: November 2022

Polymorphism (rs1805086), c.458A>G, p.Lys(K)153Arg(R), (K153R) of the myostatin gene (MSTN) has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether MSTN rs1805086 K and R allelic variants are valid genetic factors that can affect the strength phenotype of athletes’ skeletal muscles. The aim is to conduct a systematic review and meta-analysis of the association of MSTN rs1805086 polymorphism with the strength phenotype of athletes. This study analyzed 71 research articles on MSTN and performed a meta-analysis of MSTN K153R rs1805086 polymorphism in strength-oriented athletes and a control (non-athletes) group. It was found that athletes in the strength-oriented athlete group had a higher frequency of the R minor variant than that in the control group (OR = 2.02, P = 0.05). Thus, the obtained results convincingly demonstrate that there is an association between the studied polymorphism and strength phenotype of athletes; therefore, further studies on this association are scientifically warranted.
Larvicidal and Antifeedant Effects of Copper Nano-Pesticides against Spodoptera frugiperda (J.E. Smith) and Its Immunological Response
Authors: Rahman Afroja , Pittarate Sarayut , Perumal Vivekanandhan , Rajula Julius , Thungrabeab Malee , Mekchay Supamit , Krutmuang Patcharin 
Published: November 2022

This study aimed to synthesize and evaluate the efficacy of CuO NPs (copper oxide nanoparticles) with varying test concentrations (10–500 ppm) against larvicidal, antifeedant, immunological, and enzymatic activities against larvae of S. frugiperda at 24 h of treatment. Copper nanoparticles were characterized by using a scanning electron microscope (SEM) and energy dispersive X-ray (EDaX) analysis. The EDaX analysis results clearly show that the synthesized copper nanoparticles contain copper as the main element, and the SEM analysis results show nanoparticle sizes ranging from 29 to 45 nm. The CuO NPs showed remarkable larvicidal activity (97%, 94%, and 81% were observed on the 3rd, 4th, and 5th instar larvae, respectively). The CuO NPs produced high antifeedant activity (98.25%, 98.01%, and 98.42%), which was observed on the 3rd, 4th, and 5th instar larvae, respectively. CuO NPs treatment significantly reduced larval hemocyte levels 24 h after treatment; hemocyte counts and sizes changed in the CuO NPs treatment compared to the control. After 24 h of treatment with CuO NPs, the larval acetylcholinesterase enzyme levels decreased with dose-dependent activity. The present findings conclude that CuO NPs cause remarkable larvicidal antifeedant activity and that CuO NPs are effective, pollution-free green nano-insecticides against S. frugiperda.
Developing of SiO2 Nanoshells Loaded with Fluticasone Propionate for Potential Nasal Drug Delivery: Determination of Pro-Inflammatory Cytokines through mRNA Expression
Authors: Mehmood Yasir , Shahid Hira , Rashid Md Abdur , Alhamhoom Yahya , Kazi Mohsin 
Published: November 2022

Mesoporous Silica Nanoparticles (MSN) are porous inorganic materials that have been extensively used for drug delivery due to their special qualities, such as biocompatibility, biodegradability, and non-toxicity. MSN is a promising drug delivery system to enhance the efficacy and safety of drug administration in nasal diseases like chronic rhinitis (CR). In this study, we used the sol-gel technique for MSN synthesis and incorporate fluticasone propionate (FP) for intranasal drug administration for the treatment of chronic rhinitis (CR). In order to confirm the particle size, shape, drug release, and compatibility, various instruments were used. MSN was effectively prepared with average sizes ranging between 400 ± 34 nm (mean ± SD) as measured by dynamic light scattering (DLS), while zeta potential verified in all cases their positive charged surface. To investigate MSN features, the Fourier transform infrared spectrometer (FTIR), scanning electron microscopy (SEM), transmission electron microscope (TEM), thermal analysis, X-ray diffraction (XRD), and nitrogen adsorption/desorption measurement were used. The loaded compound was submitted to in vitro dissolution tests, and a remarkable dissolution rate improvement was observed compared to the crystalline drug in both pH conditions (1.2 and 7.4 pH). By using an MTT assay cell viability was assessed. The expression levels of the anti-inflammatory cytokines IL-4 and IL-5 were also measured using mRNA extraction from rat blood. Other characterizations like acute toxicity and hemolytic activity were also performed to confirm loaded MSN safety. Loaded MSN was incorporated in nasal spray prepared by using innovator excipients including poloxamer. After this, its nasal spray’s physical characteristics were also determined and compared with a commercial product (Ticovate).
Identification and Pathogenicity of Pestalotiod Fungi Associated with Woody Oil Plants in Sichuan Province, China
Authors: Li Wen-Li , Dissanayake Asha J. , Zhang Tian , Maharachchikumbura Sajeewa S. N. , Liu Jian-Kui 
Published: November 2022

Pestalotiod fungi are associated with a wide variety of plants worldwide and occur as endophytes, pathogens, and saprobes. The present study provides an updated phylogeny for genera Neopestalotiopsis, Pestalotiopsis, and Seiridium using fresh collections from woody oil plants (Camellia oleifera, Olea europaea, Paeonia suffruticosa, Sapium sebiferum, and Vernicia fordii) in Sichuan Province, China. We coupled morphology and combined sequence data analyses of ITS, tub2, and tef1-α for Neopestalotiopsis and Pestalotiopsis, with ITS, LSU, tub2, tef1-α, and rpb2 for Seiridium. Three novel species of Neopestalotiopsis (N. mianyangensis, N. paeonia-suffruticosa, N. terricola) and three of Seiridium (S. guangyuanum, S. vernicola, S. oleae), were found. Three other species, Pestalotiopsis kenyana, Seiridium ceratosporum, and S. rosarum were identified and reported as new records. All isolated species are fully described and illustrated. Additionally, the sexual morph of Pestalotiopsis kenyana is described for the first time. Pathogenicity tests revealed that Neopestalotiopsis mianyangensis, N. paeonia-suffruticosa, N. terricola, Pestalotiopsis kenyana, Seiridium guangyuanum, S. vernicola, and S. oleae are pathogenic on detached olive leaves.
Mapping the Transcriptome Underpinning Acute Corticosteroid Action within the Cortical Collecting Duct
Authors: Loughlin Struan , Costello Hannah M. , Roe Andrew J. , Buckley Charlotte , Wilson Stuart M. , Bailey Matthew A. , Mansley Morag K. 
Published: November 2022

Key Points

We report the transcriptomes associated with acute corticosteroid regulation of ENaC activity in polarized mCCDcl1 collecting duct cells.Nine genes were regulated by aldosterone (ALDO), 0 with corticosterone alone, and 151 with corticosterone when 11βHSD2 activity was inhibited.We validated three novel ALDO-induced genes, Rasd1, Sult1d1, and Gm43305, in primary cells isolated from a novel principal cell reporter mouse.

Background
Corticosteroids regulate distal nephron and collecting duct (CD) Na+ reabsorption, contributing to fluid-volume and blood pressure homeostasis. The transcriptional landscape underpinning the acute stimulation of the epithelial sodium channel (ENaC) by physiological concentrations of corticosteroids remains unclear.

Methods
Transcriptomic profiles underlying corticosteroid-stimulated ENaC activity in polarized mCCDcl1 cells were generated by coupling electrophysiological measurements of amiloride-sensitive currents with RNAseq. Generation of a principal cell-specific reporter mouse line, mT/mG-Aqp2Cre, enabled isolation of primary CD principal cells by FACS, and ENaC activity was measured in cultured primary cells after acute application of corticosteroids. Expression of target genes was assessed by qRT-PCR in cultured cells or freshly isolated cells after the acute elevation of steroid hormones in mT/mG-Aqp2Cre mice.

Results
Physiological relevance of the mCCDcl1 model was confirmed with aldosterone (ALDO)-specific stimulation of SGK1 and ENaC activity. Corticosterone (CORT) only modulated these responses at supraphysiological concentrations or when 11βHSD2 was inhibited. When 11βHSD2 protection was intact, CORT caused no significant change in transcripts. We identified a small number of ALDO-induced transcripts associated with stimulated ENaC activity in mCCDcl1 cells and a much larger number with CORT in the absence of 11βHSD2 activity. Principal cells isolated from mT/mG-Aqp2Cre mice were validated and assessment of identified ALDO-induced genes revealed that Sgk1, Zbtbt16, Sult1d1, Rasd1, and Gm43305 are acutely upregulated by corticosteroids both in vitro and in vivo.

Conclusions
This study reports the transcriptome of mCCDcl1 cells and identifies a small number of ALDO-induced genes associated with acute stimulation of ENaC, including three previously undescribed genes.
IMPLEMENTATION OF 360-DEGREE FEEDBACK AND SAW FOR DECISION SUPPORT SYSTEM OF ACHIEVING TEACHER'S RECOMMENDATION
Authors: Ginting Novita BR , Syarif Zulkarnaen Noor , Maesaroh Mamay , Jaenudin Jejen , Widhyaesteoty Dahlia , Yusup Muhamad Alfian , Ningrum Leny Tritanto 
Published: November 2022

Education requires quality teacher resources in the current era of industry 4.0 and society 5.0. Teachers act as educators, teachers, mentors, directors, trainers, assessors, and evaluators. Students must have critical thinking competencies, creativity and innovation, interpersonal and communication skills, teamwork and collaboration, and self-confidence. At SMK Yasbam, the selection process for outstanding teachers is carried out every year. The problem faced is that the selection process is still assessed, selected, and determined by the school principal only, so there is still a process that is deemed not transparent, accountable, and fair. To make the assessment process fairer, try using the 360-degree feedback method, a multi-source assessment, and then weighting the performance value using the Simple Additive Weighting method to obtain recommendations for outstanding teachers. Respondents consisted of principals, fellow teachers, students, and themselves (the assessed teachers). Furthermore, combining these two methods is applied in a decision support system to make the assessment process and selection of outstanding teachers more objective.
Hubungan Antara Kesesakan dengan Stres pada Istri di Rumah Susun dan Sewa (Rusunawa) Kota Padang
Authors: Feby Fadilla  , Fikri Harry Theozard , Ade Frihapma Semita 
Published: November 2022

Kesejahteraan merupakan hal yang diharapkan oleh setiap keluarga dalam masyarakat, karena tingkat kesejahteraan keluarga mencerminkan kualitas kehidupan keluarga. Implikasi ini terkadang tidak sejalan dengan harapan yang seharusnya terjadi, karena masih terdapat keluarga yang berstatus sebagai Masyarakat Berpenghasilan Rendah (MBR). Salah satu solusi yang dihadirkan adalah dengan penyediaan rumah susun dan sewa (Rusunawa). Berdasarkan bukti-bukti yang didapatkan, para istri yang tinggal di Rusunawa mengalami gejala yang berhubungan dengan stres, selain itu faktor lingkungan dan kondisi rusunawa juga menimbulkan gejala kesesakan yang dirasakan oleh para istri. Tujuan dari penelitian ini adalah untuk mengetahui hubungan kesesakan dengan stres pada istri di rumah susun dan sewa kota Padang. Variabel bebas dalam penelitian ini adalah kesesakan dan variabel terikat adalah stres. Alat ukur yang digunakan dalam penelitian ini yaitu skala kesesakan dan skala stres. Teknik pengambilan sampel dalam penelitian ini ialah 72 orang istri yang tinggal di Rusunawa Kota Padang. Uji validitas dan reliabilitas pada penelitian ini menggunakan teknik Alpha Cronbach. Hasil koefisian validitas pada skala kesesakan bergerak dari rix = 0.307 sampai dengan rix = 0.781 dengan koefisian reliabilitas α = 0.937 sedangkan pada skala stres bergerak dari rix= 0.304 sampai dengan rix= 0.707 dengan koefisian reliabilitas α = 0.940. Berdasarkan analisis data, diperoleh nilai korelasi sebesar 0.438 dengan taraf signifikan 0.000 yang berarti diterima. Hal ini menunjukkan bahwa ada hubungan yang signifikan antara kesesakan dengan stres pada istri di Rumah Susun dan Sewa (Rusunawa) Kota Padang. Adapun sumbangan efektif dari variabel kesesakan terhadap variabel stres sebesar 19%.
An Impact Assessment of Socio-Medical Approach to Managing Women Living With HIV/AIDS Based on the Opinions of Patients in Heart-To-Heart Centres in Calabar Metropolis, Nigeria
Authors: Eneji Rosemary I. , Odey Stephen Adi , Nwagbara Eucharia , Anake Ushie Michael , Emeka Josephat Owan , Archibong Esther P. , Ballanytne Ikpeme Bassey , Li Xiaoyun 
Published: November 2022

Nigerian women living with HIV/AIDS do face social, psychological and physical challenges in their daily lives. The objectives of this study were to determine how elements of the socio-medical approach have contributed to managing their health problems in Calabar metropolis, Nigeria. Six hundred women, aged 15-60 years, were sampled from Hearth-to-Heart Centers for their opinions on the socio-medical approach to managing their condition. The women expressed reasonable satisfaction with the availability and accessibility of socio-medical services: all of them received counselling, 92.2% were counselled on adherence, 81.7% received anti-retro viral services and 64.2% enjoyed family planning services. Some of the routine challenges highlighted by the women were poverty and fear of rejection by society. Also, the use of family planning does hinder their adherence to antiretroviral treatment. Overall, the socio-medical approach has been successful in managing their illness; more women should thus avail themselves of the opportunity of enjoying good health despite their HIV status.

Received: 22 July 2022 / Accepted: 22 October 2022 / Published: 5 November 2022
Customary Values and Daily Communication of the Baduy Community in Indonesia
Authors: Enjang . 
Published: November 2022

This article describes how customary values have implications for communication practices in the daily life of the Baduy people, one of the famous indigenous communities in Indonesia. Utilizing the ethnography of communication method, this study describes how customary values in the Baduy community have contributed in establishing local-ecological consciousness and primordial outlook which is reflected in their communication on daily basis. Practically, the Sundanese language used by the Baduy people is different from the main Sundanese, especially in the context of dialect and structure as they do not have any concept of language level which is commonly found in mainstream Sundanese while their dialect is more loud and straight. Furthermore, in daily communication, they also apply language taboos through a sort of law and norm so-called “pikukuh” by prohibiting of certain words which philosophically related to their basic belief. Therefore, language taboos in the Baduy community can also be understood as symbolic messages based on their local-primordial outlook.

Received: 14 August 2022 / Accepted: 20 October 2022 / Published: 5 November 2022
The Impact of Contracts Administration on the Performance of Road Construction Projects in Uganda: A Literature Gap
Authors: Namakula B. , Matsiliza N. S. , Chikafalimani S. H. P. , Manga M. , Kibwami N. 
Published: November 2022

Uganda's road construction industry has experienced growth over time because of increased budget allocations. Although the industry has dramatically improved, projects are still experiencing challenges, including but not limited to cost overruns, time overruns, incompetent staff, poor designs, site-related challenges, inadequate resources, low innovation and shoddy work. These are the factors affecting the performance of road projects in Uganda. Therefore, as a way to address the mentioned issues and improve the road construction industry, this paper, through the literature review, looked at the concept of construction contract administration and its context on project implementation. A scoping review of the most relevant work in the field of road construction with emphasis on contract administration and the performance of road construction projects in Uganda presented a salient gap in the area of contract administration. The purpose of this study is to review the literature on the impact of contracts administration on road construction projects which is forming the basis of ongoing research to develop a contract administration strategy that will be used on road construction projects with the aim of improving the performance of road construction projects in Uganda.

Received: 29 July 2022 / Accepted: 1 October 2022 / Published: 5 November 2022
The Benefit of Using a Psychoeducation Program Integrated with Quranic Values to Mathematics Anxiety Among Students
Authors: Winarso Widodo , Alsa Asmadi , Khilmiyah Akif 
Published: November 2022

An innovative approach to education should be provided in Mathematics learning activities to battle anxiety. However, studies on handling mathematical anxiety problems through psychoeducational programs have not been conducted. This study aims to analyze the benefits of implementing a psychoeducational program that integrates Qur’anic values on students’ mathematics anxiety. The quasi-experimental research was applied to junior high schools in Indonesia, consisting of experimental and control groups. Furthermore, the mathematical anxiety scale was used as a data collection technique, while the Kruskal-Wallis Test was used for analysis. The results showed that the application of psychoeducational programs is beneficial in reducing students’ mathematics anxiety levels. Therefore, psychoeducation programs integrated with Quranic values are recommended for mathematics learning activities. The application is suitable for various groups of students. However, initial training is needed for teachers to have a level of mastery of scientific integration (Islam), hence the application of the programs can run well.

Received: 8 August 2022 / Accepted: 5 October 2022 / Published: 5 November 2022