bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Potential Immunogenic Epitopes Against SARS-CoV-2
Using In-Silico Method: An Immunoinformatics Study
Authors: Sugumar Shobana , Sankaralingam Subikshaa , Parthasarathy Sathishnath , Nandamuri Chethan Jaya Sai , Ramanathan Shruti 
Published: April 2022

Background:
Severe Acute Respiratory Syndrome (SARS-CoV-2), a zoonotic virus, is the pathogenic causal agent for the ongoing pandemic. Despite the lethality of the disease, there are no therapeutic agents available to combat the disease outbreak; and the vaccines currently accessible are insufficient to control the widespread, fast-mutating virus infection.

Objective:
This research study focuses on determining potential epitopes by examining the entire proteome of the SARS-CoV-2 virus using an in-silico approach.

Methods:
To design a vaccine for the deadly virus, the entire proteome of the SARS-CoV-2 virus was screened for identification of potential epitopes in order to identify the potent peptide candidate which is both unique and simultaneously solves the purpose of the vaccine discovery. It is mandatory to identify the suitable B-cell and T-cell epitopes of the observed SARS-CoV-2 Surface Glycoprotein (QKN61229.1). These epitopes were subjected to various tests, including antigenicity, allergenicity, and other physicochemical properties. The T-cell epitopes that met all of the criteria were then subjected to Population Coverage Analysis. It helped better understand the response of epitopes to the target population, compute the conservancy of a peptide, and then cluster them based on their sequence match, MHC binding, and T-cell restriction sites. Lastly, the interactions between the T-Cell Receptor (TCR) and a peptide-MHC were studied to gain a thorough understanding of MHC-restriction to design a peptide-vaccine.

Results:
The results showed that there were 4 B-Cell epitopes, 2 MHC-I epitopes, 4 MHC-II epitopes that qualified all the subjected tests and thus have an affinity to prominent antigens.

Conclusion:
ased on the results obtained from this study, the estimated peptides are a promising candidate for peptide-vaccine design and development.
Herbal-Based Dressings in Wound Management
Authors: Thomas Asha , Nikam Aniket , Giram Prabhanjan , Nagore Dheeraj , Chitlange Sohan 
Published: April 2022

Abstract:
Wound management is one of the major global challenges in recent times, and woundassociated
infection has a significant impact on the healthcare economy worldwide. Wounds can be
acute or chronic type, also diabetic, trauma, accidental, burn wounds and minor cuts, bruises, and
rashes, etc. One of the primary treatment options available in these conditions are the use of suitable
dressing materials to cover the wound and accelerate the healing process. Since ancient times,
according to archaeological theories, medicinal plants and oils have been employed for the treatment
of wounds. Today researchers across the globe are focusing their efforts on fabrication of
novel dressing materials that can provide the most effective treatment, easy exchange of nutrients,
and absorb exudate from the wounds. Very lately, various research groups are also concentrating
on the design and development of herb-loaded wound dressings, as herbal preparations contain
numerous phytoconstituents with a broad spectrum of pharmacological properties when compared
to synthetic drugs and also due to the perceived notion that herbal products are generally safe, even
when administered over prolonged periods. They contain numerous bioactive that can act on the
various phases of the wound healing process, providing an ideal environment for the healing process.
The present review discusses the numerous approaches that are employed for the preparation
of dressing materials incorporated with plant-derived phytoconstituents/extracts. This review also
provides an insight into the healing process and wound healing agents derived from medicinal
plants and oils. The review can serve as a database for researchers working in this field and can
help them to select the most appropriate dressing material for the effective delivery of herbal preparations
in the management of wounds.
Does Nicotine from Passive Smoking and Foods Protect Against
Parkinson’s Disease?
Authors: Faramarzi Elnaz , Fathalizadeh Arezoo , Sanaie Sarvin , Mirghafourvand Mojgan , Reyhanifard Anita , Rahnemayan Sama , Mahmoodpoor Ata 
Published: April 2022

Background:
There is generally a strong link between smoking, more particularly,
passive smoking, and the occurrence of various illnesses and health-related disorders. Also, there
is a globally recognized epidemiological link between smoking and Parkinson’s disease (PD).
However, the current data on passive smoking are contradictory. Thus, this paper extracted the
inconsistent existing studies to systematically shed light on the slightly ambiguous protective
properties of dietary nicotine and passive smoking as influential factors against PD.

Method:
This systematic review was registered in PROSPERO (CRD042020160707). Two independent
researchers searched through the following databases: PubMed, Cochrane Library,
Scopus, Ovid, Embase, Google Scholar, and ProQuest to find relevant dissertations and theses.
This study involved the data of papers published until 30th September, 2020. The Newcastle-
Ottawa scale (NOS) was used for case-control and cohort studies for quality assessment. The
study extracted cases without a history of smoking and the number of patients with PD in the
workspace, home, and lifetime and organized them based on each research. The study implemented
Q-statistic to investigate the selected papers based on statistical heterogeneity.

Result:
In total, four cohorts and five case-control papers were included. Our findings indicated
that lifetime exposure to smoking had a protective effect against PD risks (OR: 0.84; 95% CI:
0.70-0.99; p =0.04). However, the settings, workspace, home exposure, and PD risk did not display
to have any considerable relationship. It should be noted that the studies on the relationship
between dietary nicotine and PD risks have revealed the protective effect of nicotine-rich foods,
like potatoes, tomatoes, and peppers, on PD risks.

Conclusion:
In light of the observational studies covered in this paper, its findings should receive
an organized interpretation while identifying the relevant mechanisms of this association.
Influence of Heating on the Physico-Biochemical Attributes of Milk
Authors: Goswami Tridib Kumar , De Baishakhi , Pandey Suravi , Pou Jolvis , Sharma Sadananda P. , Raghavan Vijaya G.S. 
Published: April 2022

Background:
Milk, the fluid secreted by the female of all mammalian species, fulfills
the complete nutritional and energy requirements. Milk is a single balanced diet enriched in
physiologically important proteins and peptides, enzymes, enzyme inhibitors, immunoglobulins,
growth factors, hormones, and antibacterial agents. Milk can be converted to different dairy
items that occupy an important place in confectioneries and beverages and thus are subjected to
various processing conditions.

Objective:
This review aims to discuss how the processing conditions affect the physicobiochemical
and nutritional attributes of milk protein and influence its functionality with a major
focus on heating or thermal treatment.

Methods:
Detailed literature surveys with keywords ‘thermal effect of milk proteins’, ‘dairy
chemistry’, ‘Maillard reactions have been done in food science, food chemistry, dairy science,
functional foods journals, PubMed, and Scopus for gathering information on thermal effects on
milk proteins. Out of 25 shortlisted review and research articles, 20 most relevant ones were cited
and enlisted as references.

Results:
Due to thermal treatment during dairy processing, the chemical characteristics of milk
proteins are altered because of chemical changes like glycation, aggregation and denaturation.
Chemical modifications influence the functionality, digestibility, and nutritional quality of milk
proteins.

Conclusion:
Novel milk processing technologies viz. ohmic and microwave heating, pulsed electric
field, high hydrostatic pressure, microfiltration and ultrasound find applications in dairy processing.
Such non-thermal technologies do not involve heat to kill the microbes; thus reducing
the detrimental effect of conventional heat treatments on milk quality.
Prospects for Neurotrophic Factor-Based Early Intervention in Schizophrenia:
Lessons Learned from the Effects of Antipsychotic Drugs on
Cognition, Neurogenesis, and Neurotrophic Factors
Authors: Khan Mohammad M. , Parikh Vinay 
Published: April 2022

Abstract:
Although reducing psychotic symptoms in schizophrenia has been a major focus of therapeutic
interventions for decades, improving cognition is considered a better predictor of functional
outcomes. However, the most commonly prescribed antipsychotic drugs (APDs) show only marginal
beneficial effects on cognition in patients with schizophrenia. The neural mechanisms underlying cognitive
disturbances in schizophrenia remain unknown that making drug development efforts very challenging.
Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity,
learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis
and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and
how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing
therapies to combat cognitive deficit in schizophrenia. Numerous evidence produced over the
years suggests a deficit in a wide spectrum of neurotrophic factors in schizophrenia. Since schizophrenia
is considered a neurodevelopmental disorder, early intervention with neurotrophic factors may be
more effective in ameliorating the cognitive deficits and psychopathological symptoms associated with
this pathology. In this context, results from initial clinical trials with neurotrophic factors and their future
potential to improve cognition and psychosocial functioning in schizophrenia are discussed.
A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease
Authors: Maes Michael , Asad Halah Nori , Al-Hakeim Hussein Kadhem , Moustafa Shatha Rouf 
Published: April 2022

Background:End-stage renal disease (ESRD) is associated with fatigue and physio-somatic symptoms.Objective:To delineate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt/catenin-pathway proteins.Methods:The Wnt-pathway related proteins β-catenin, Dickkopf-related protein 1 (DKK1), R-spondin-1, and sclerostin were measured by ELISA technique in 60 ESRD patients and 30 controls. The Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale was used to assess the severity of FF symptoms.Results:ESRD is characterized by a significant increase in the total FF score, muscle tension, fatigue, sadness, sleep disorders, gastro-intestinal (GI) symptoms, and a flu-like malaise. The total-FF score was significantly correlated with serum levels of urea, creatinine, and copper (positively), and β-catenin, eGFR, hemoglobin, albumin, and zinc (inversely). The total-FF score was associated with the number of total dialysis and weekly dialysis sessions, and these dialysis characteristics were more important in predicting FF scores than eGFR measurements. Partial Least Squares analysis showed that the FF score comprised two factors that are differently associated with biomarkers: a) 43.0% of the variance in fatigue, GI symptoms, muscle tension, sadness, and insomnia is explained by hemoglobin, albumin, zinc, β-catenin, and R-spondin-1; and b) 22.3% of the variance in irritability, concentration and memory impairments by increased copper and cations/chloride ratio, and male sex.Conclusion:ESRD patients show high levels of fatigue and physio-somatic symptoms, which are associated with hemodialysis and mediated by dialysis-induced changes in inflammatory pathways, the Wnt/catenin pathway, and copper.
Developing a Framework of Sensory Environment for Autism Centre
Authors: Ghazali Roslinda binti , Md Sakip Siti Rasidah , Samsuddin Ismail , Samra Heba 
Published: April 2022

The learning environment is critical in developing the skill and mental of children with autism. However, designers are often unaware of the sensory issues and designing a unique environment that would affect learning process. The paper's objective is to identify the main factor in creating the physical learning environment for autism. Partial Least Square Structural Equation Modelling (PLS-SEM) was conducted to develop a framework of the sensory environment. It is hoped that this paper could be an impressive contribution to technical agencies and designers during their design stage, thus creating a better physical learning environment supported with sensory design features.
Keywords: Sensory environment; autism; physical learning environment;
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3266
Face Validation of Learning Malaysian Sign Language Questionnaire (L-MySL-Q): Malaysian Sign Language (MySL) pro forma as a third language for adolescents
Authors: Tengku Jamaluddin Tengku Intan Baizura , Mohd Rashid Syar Meeze , Broome Emma , Mohd Hassan Naffisah 
Published: April 2022

Malaysian Sign Language (MySL) uses visual-manual modalities for delivering information and communicating involving movements of the finger, hand, arm gestures, and facial expressions. A newly-developed instrument tool: Learning-MySL-Questionnaire (L-MySL-Q) from validated questionnaires [Rogers 1995; ELQ, University of Nottingham, UK] consisting of the diffusion model to gauge willingness and readiness for students to adopt MySL as a third language undergone face validation upon completion of Introduction to MySL Pro Forma leson. Findings showed positive feedback from respondents in comparison to pre-intervention among typical children and adolescents. This comprehensive pro forma inculcates a fun learning process while inculcating patriotism among learners.
Keywords: inclusive communication, Malaysian Sign Language, third language, adolescents
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI:https://doi.org/10.21834/ebpj.v7i19.3273
COMPARATIVE MODELING FOR SACCHAROMYCES CEREVISIAE RAD56 USING SWISS-MODEL, I-TASSER, AND PHYRE2
Authors: PARITALA VENU 
Published: April 2022

Objective: RAD56 is a protein its causes pathological conditions of Kohler disease, Mueller-Weiss syndrome, which leads to hindfoot pain. RAD56 is considered an impressive drug target for various illnesses. The experimental 3D structure of RAD56 is not available. Therefore, the present study aims in developing a homology model using 3 different software and evaluate the best model.
Methods: The developing homology modeling on RAD56 is built utilizing three diverse software’s to be specific Swiss-Model, I-Tasser, and Phyre2. All the predicted models were analyzed and approved by PROCHECK, PROSA, Errat, and Verify_3D.
Results: Homology Modeling anticipated from Swiss-Model appeared best comes about with 88.6% of the buildups within the most favorable locale, 11.2% within the permitted region, 0.6% within the liberally permitted locale, and 0.2% within the refused locale. PROCHECK, PROSA, Errat, and Verify_3D, too, affirmed the same.
Conclusion: Homology Modeling was created for RAD56 utilizing Swiss-Model, I-Tasser, and Phyre2. The models created were validated utilizing PROCHECK, PROSA, Errat, and Verify_3D. This investigation approved the homology model created by is best Swiss-Model 88.6, vigorous as well as solid sufficient to be utilized for future pondering.
Quão big o seu data deve ser?
Authors: Baltar Ronaldo , Baltar Claudia 
Published: April 2022

Esse conteúdo digital foi criado como parte da atividade de capacitação
”Introdução ao R e RStudio para ciência social computacional”. É uma
iniciativa de formação e difusão científica
do Observatório de Populações e
Políticas Púbicas (ObPPP) e do
Programa de Formação
Complementar de Graduação em Pesquisa Social Computacional (InfoSoc),
ambos vinculados ao Dept.º C.
Soc. / CLCH, Universidade Estadual de Londrina (UEL), Paraná - Brasil
Karakteristik Lokasi Putar Balik Km. 8,7 Terhadap Jalan Zainal Abidin Pagar Alam Kota Bandar Lampung
Authors: Abdillah Sjaheru Muhammad , Wardono Herry , Kustiani Ika 
Published: April 2022

Jalan Z.A. Pagar Alam dengan tingkat kemacetan yang sangat tinggi terutama pada saat jam sibuk. Kemacetan juga terjadi akibat adanya beberapa lembaga pendidikan di dekat lokasi penelitian yaitu : Sekolah Darma Bangsa, IBI Darmajaya, Universitas Muhammadiyah, UBL, dan lembaga-lembaga lainya seperti SPBU, Dinas Peternakan dan Kesehatan Hewan dan berbagai warung makan yang berdiri di ruas jalan. Tujuan dari penelitian pada jalan Z.A. Pagar Alam adalah peneliti dapat Mengetahui volume dan kecepatan kendaraan yang melintas di jalan ZA. Pagar Alam, Menghitung nilai waktu Gap Acceptance yang terjadi pada U-Turn, Mencari nilai waktu Follow Up Time yang terjadi pada U-Turn dan Menghitung besarnya antrian yang terjadi. Berdasarkan analisis dan perhitungan yang telah dilakukan pada Bukaan Median (U-Turn) di KM. 8,7 dapat disimpulkan bahwa pengaruh U-Turn pada hari Senin pagi dari Tanjung Karang menuju Rajabasa dan sebaliknya merupakan pengaruh terbesar terhadap kinerja lalu-lintas, yaitu gap yang terjadi sebanyak 439 kendaraan dan antrian akibat gap sebanyak 899 kendaraan, follow up time yang terjadi sebanyak 309 kendaraan dan antrian akibat follow up time sebanyak 1449 kendaraan.
Studi Kelayakan Penambahan Debit Air Daerah Irigasi Tebu System Di Kabupaten Tanggamus
Authors: Yani P F 
Published: April 2022

Untuk mengatasi kebutuhan air baku serta menunjang konservasi sumber daya air di Areal Daerah Irigasi Way Tebu, telah diidentifikasi daerah-daerah yang mempunyai potensi untuk dibuat sumber air irigasi yang akan memberikan persediaan air baku di musim kemarau bagi daerah sekitarnya.
Sebagai tindak lanjut dari identifikasi tersebut akan dilakukan Studi Kelayakan Penambahan Debit Air Daerah Irigasi Tebu System yang membutuhkan data rinci atas kondisi topografi, geologi permukaan maupun kondisi bawah permukaan di sekitar lokasi rencana sumber air irigasi, data hidrologi dan hidrolika, sosial ekonomi masyarakat sekitar dan data penunjang desain Iainnya sedemikian rupa sehingga diharapkan hasil desain merupakan altematif konstruksi terbaik. Dengan kondisi demikian maka pemenuhan kebutuhan air di Daerah Irigasi Way Tebu dapat dipenuhi.
Areal Daerah Irigasi Way Tebu tersebut telah ditetapkan sebagai kawasan sentra budidaya padi bagi Kabupaten Tanggamus (Lumbung Padi). Sehingga perlu dikembangkan suatu kawasan yang berfungsi sebagai penyangga alternatif kebutuhan air bagi Daerah Irigasi Way Tebu System. Salah satu alternatif yang telah diidentifikasi adalah pemanfaatan sumber air dari DAS sekitar Daerah Irigasi Way Tebu System. Sumber air irigasi ini merupakan permintaan dari masyarakat setempat, yang mempunyai areal sawah di Daerah Irigasi Way Tebu System.
Studi Penanganan Amblesan Jalan Kereta Api di Km. 467+000 – Km.467+500 Antara Bungamas – Sukaraja Lintas Lahat – Lubuk Linggau
Authors: Siregar A M 
Published: April 2022

Segmen Bungamas - Sukarja merupakan salah satu bagian dari jalur utama kereta api yang dibangun pada tahun 1927 oleh pemerintah Belanda yang menghubungkan Kota Palembang dengan Kota Lubuk Linggau. Berkembangnya Provinsi Sumatera Selatan di banyak bidang harus didukung dengan meningkatkan kualitas layanan transportasi massal kereta api agar dapat memenuhi kriteria perencanaan sehingga dapat melayani kegiatan operasional angkutan penumpang dan barang. Salah satu upaya yang dilakukan adalah menyelesaikan beberapa permasalahan yang terjadi, salah satunya adalah penurunan gradien geometrik jalan KA yang cukup signifikan akibat amblesan yang terjadi pada Km. 467+000 sd 467+500. Hasil pengujian tanah di lokasi menunjukkan bahwa kondisi kadar air pada struktur badan jalan KA sampai kedalaman -2,4 m mempunyai rata – rata kadar air cukup tinggi yaitu sebesar 40%. Disamping itu, nilai CBR tanah pada kedalaman ini juga belum memenuhi persyaratan yaitu hanya 4% dimana syarat minimum yaitu 8%. Upaya penanganan amblesan yang dilakukan adalah dengan cara perbaikan gradien jalan ka dengan melakukan normalisasi struktur badan jalan KA sehingga diperoleh gradien yang sesuai dengan kondisi lokasi. Normalisasi badan jalan KA dilakukan dengan mengembalikan kondisi badan jalan sesuai dengan peraturan dengan panjang 375 m pada daerah timbunan dan 125 m pada daerah galian. Untuk menstabilkan posisi lereng, dilakukan pemasangan tembok penahan tanah sepanjang 250 m pada daerah timbunan dan 75 m pada daerah galian. Agar kondisi badan jalan tetap pada kondisi optimal, maka dilakukan juga perbaikan sistem drainase yang diarahkan menuju box culvert yang merupakan titik pembuangan air di lokasi tersebut.
Kebijakan Penataan Permukiman Kumuh Pada Kampung Kota Di Teluk Betung, Kota Bandar Lampung
Authors: Maisyaroh S 
Published: April 2022

Metropolisasi merupakan fenomena global yang terjadi di setiap kota di dunia dan memiliki ciri-ciri berbeda antara satu kota dengan kota yang lainnya. Begitu juga yang terjadi di kota-kota besar di Indonesia. Semenjak merebut kemerdekaannya dari Belanda, Indonesia terus berkembang menjadi negara terpadat populasinya dan menempati urutan kelima di dunia. Konsentrasi populasi terjadi di perkotaan. Kegiatan ekonomi dan lainnya mengundang penduduk untuk menetap di kota. Permasalahan kurangnya permukiman pun timbul sehingga permukiman kumuh mulai tumbuh.
Kebijakan pemerintah tentang penataan permukiman kumuh pun mulai dilaksanakan. Mulai dari Kampung Improvement Program sampai dengan program Neighborhood Upgrading and Shelter Sector Project/NUSSP) dan pembangunan rumah susun. Kota Bandar Lampung yang merupakan ibukota Propinsi Lampung pun memiliki jumlah permukiman kumuh yang cukup banyak, salah satunya adalah kawasan Teluk Betung. Untuk menganalisa kebijakan yang diambil dalam menangani kawasan kumuh di kota ini, akan di bahas kebijakan pemerintah mulai dari Rencana Tata Ruang Propinsi hingga Rencana Detil Tata Ruang Kota Bandar Lampung. Aktor yang berperan dalam menangani permasalahan permukiman kumuh pun dibahas untuk mengetahui langkah aktual dalam perbaikan permukiman kumuh.
Instrument pengendali panduan harga upah dan bahan di kabupaten/kota pada program BSPS Provinsi Lampung
Authors: Liwitara Rangi 
Published: April 2022

Panduan harga satuan bahan bangunan merupakan sebuah inovasi dalam pelaksanaan Program Bantuan Stimulan Rumah Swadaya (BSPS). Panduan ini bertujuan untuk mengendalikan harga bahan bangunan dan upah tukang dengan cara membuat instrumen pengukuran dan menentukan indikator harga satuan untuk standarisasi nilai upah tukang dan harga bahan bangunan.
Dengan adanya panduan upah tukang dan harga satuan bahan bangunan yang terstandar, diharapkan dapat mempermudah Calon Penerima Bantuan (CPB) dalam menentukan perkiraan nilai bangunan berdasarkan harga satuan tertinggi yang dapat dipertanggung jawabkan. Harga yang dimaksud adalah harga pasar wajar pada masing-masing Kabupaten/Kota.