bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of a prehospital-initiated redirection program for patients with low-acuity conditions: an 18-month retrospective cohort study
Authors: Mohamed Ilyas Abdi , Harrisson Jessica , Blanchard Pierre-Gilles , Lemire Lily-Pier , Houde Laurence , Emond Marcel , Nadeau Alexandra , Mercier Eric 
Published: May 2022

Abstract
Objectives
This study aims to describe the profile of patients and the barriers encountered in implementing an emergency medical services (EMS)-initiated redirection program to non-emergency department (ED) settings during the COVID-19 pandemic.
Methods
This is a retrospective cohort study. All EMS interventions during which the coordinating redirection centre (Capitale-Nationale, Quebec, Canada) was called were reviewed. The centre was available weekdays during working hours. On a voluntary basis, the on-site emergency medical technician (EMT) had the opportunity to contact the redirection centre to initiate diversion of patients with non-urgent conditions to a non-ED setting.
Results
Between April 27th, 2020, and October 26th, 2021, 2741 calls were received at the redirection centre, of which 1206 patients were finally diverted. Most redirected patients were female (62.0%) and 73.2% were aged ≥ 60 years old. The initial 911 Medical Dispatch Priority Systems (MDPS) codes of those redirected were sick person (37.3%) and falls (11.3%) while 58.9% were initially considered as low ambulance priority level (P4, P7). The main complaints of redirected patients were non-traumatic lower limb pain (17.8%), back pain (12.0%), neurologic disorder (8.3%), mental-health related condition (7.9%), skin disorder (6.7%) and fall (6.5%). Patients were most frequently redirected to a general practice clinic (45.1%), a community-based resource (20.1%) or their own family physician (11.9%). The main reasons for not redirecting, available for 1112 interventions, were the potential for deterioration (88.8%), patient not consenting to be redirected (7.2%) and no outpatient clinic availability (4.9%).
Conclusions
A redirection program initiated by EMTs was implemented in the context of the COVID-19 pandemic. Older adults and those presenting with lower limb and back pain were the main populations redirected. Promoting the program to paramedics and leveraging this opportunity to compare different models of care are the upcoming steps.
S100A9 as an inflammatory marker in hospitalized COVID-19 patients
Authors: Barbosa Larissa Gomes , Silva Artur Christian Garcia , Oliveira Juliana Marques , Klein Mary Hellen Fabres , Klein Raphael Contelli , Venâncio Larissa Paola Rodrigues , Santos Theo Araújo , Souza Pedro Paulo Chaves , Lima Jonilson Berlink 
Published: May 2022

Abstract
Objective: To evaluate serum levels of S100A9 as an inflammatory marker of unfavorable outcomes in patients with COVID-19 in a cross-section study.Material: Participants in this study were allocated from reference care units for the diagnosis of COVID-19 in the western region of Bahia, Brazil, from May 2020 to June 2021.Methods: Blood samples were collected from control group, patients with RT-qPCR positive for COVID-19 with different clinical manifestations of the disease and cured COVID-19 patients. Cytokines and inflammatory mediators (S100A9, D-dimer IL-6, IL-10, TNF-a, IL-12p70) were analyzed by ELISA/CBA.Results: Hospitalized COVID-19 patients presented increased production of S100A9, IL-6, IL-10, TNF-α, IL-12p70, and D-dimer when compared with not hospitalized patients, not infected or cured. Spearman analysis revealed a positive correlation between S100A9 and inflammatory cytokines/D-dimer. ROC curve analyses demonstrated accurate sensitivity and specificity for S100A9 and IL-6.Conclusion: S100A9 serum levels were elevated in hospitalized patients associated with unfavorable outcomes and poor prognosis in COVID-19. Thus, using S100A9 in association with other standardized parameters in clinical protocols may be a useful tool to predict critical clinical evolution during SARS-COV-2 infection.
A new view of territoriality in large eagles: the territory pre-exists regardless of their occupants.
Authors: Morollón Sara , López-López Pascual , Urios Vicente 
Published: May 2022

Abstract

1. The knowledge about territoriality and space use by predators is a topic of great interest in the study of animal behavior and conservation biology. Examining the plasticity of territory limits, the topology and how territories can be modified depending on their owners is important to deepen into the behavior of territorial species. 2. Here, we analyzed the variations and tested the similarity of the home-range of individuals from the same territory using the data provided by 51 Bonelli's eagles from 22 different territories, tagged with GPS/GSM dataloggers in eastern Spain. 3. We analyzed the percentage of overlap of the annual home-range considering the 95% kernel density estimator between individuals of the same territory. Also, we analyzed the variation in the home range size according to three different kernel levels (95%, 75% and 50%) and the annual eccentricity of each individual home-range as a complementary metric to study the topology of territories across years. We also analyzed the changes in territory size and topology after the replacement of territory owners either by a single individual or by the entire pair. 4. Our results show that territories, regardless of the occupying members, have the same topology and extension and that their limits hardly vary across time. 5. Therefore, the identification and conservation of territories of large eagles regardless of their owners are key to ensuring species recovery in the long term, which is particularly important for endangered species such as the Bonelli’s eagle. Finally, our study highlights satellite telemetry's importance in further investigating the behavioral ecology and its conservation implications in large eagles.
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Authors: Guo Hao-Bo , Perminov Alexander , Bekele Selemon , Kedziora Gary , Farajollahi Sanaz , Varaljay Vanessa , Hinkle Kevin , Molinero Valeria , Meister Konrad , Hung Chia , Dennis Patrick , Kelley-Loughnane Nancy , Berry Rajiv 
Published: May 2022

Abstract
AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can visualize, analyze and interpret the structures and functions of all proteins solely from their primary sequences. We performed AF2 structure predictions for various protein systems, including globular proteins, a multi-domain protein, an intrinsically disordered protein (IDP), a randomized protein, two larger proteins (> 1000 AA), a heterodimer and a homodimer protein complex. Our results show that along with the three dimensional (3D) structures, AF2 also decodes protein sequences into residue flexibilities via both the predicted local distance difference test (pLDDT) scores of the models, and the predicted aligned error (PAE) maps. We show that PAE maps from AF2 are correlated with the distance variation (DV) matrices from molecular dynamics (MD) simulations, which reveals that the PAE maps can predict the dynamical nature of protein residues. Here, we introduce the AF2-scores, which are simply derived from pLDDT scores and are in the range of [0, 1]. We found that for proteins with good multisequence alignment (MSA) depths, including large proteins and protein complexes, the AF2-scores are highly correlated with the root mean square fluctuations (RMSF) calculated from MD simulations. For proteins with little or no MSA hits (the IDP and randomized protein), the AF2-scores do not correlate with the RMSF from MD, especially for the intrinsically disordered proteins (IDPs). Our results indicate that the protein structures predicted by AF2 also convey information of the residue flexibility, i.e., protein dynamics.
Applied causal inference methods for sequential mediators
Authors: Zugna Daniela , Popovic Maja , Fasanelli Francesca , Heude Barbara , Scelo Ghislaine , Richiardi Lorenzo 
Published: May 2022

Abstract
Background: Mediation analysis aims at estimating to what extent the effect of an exposure on an outcome is explained by a set of mediators on the causal pathway between the exposure and the outcome. The total effect of the exposure on the outcome can be decomposed into an indirect effect, i.e. the effect explained by the mediators jointly, and a direct effect, i.e. the effect unexplained by the mediators. However finer decompositions are possible in presence of independent or sequential mediators. Methods: We review four statistical methods to analyse multiple sequential mediators , the inverse odds ratio weighting approach, the inverse probability weighting approach, the imputation approach and the extended imputation approach. These approaches are compared and implemented using a case-study with the aim to investigate the mediating role of adverse reproductive outcomes and infant respiratory infections in the effect of maternal pregnancy mental health on infant wheezing in the Ninfea birth cohort. Results: Using the inverse odds ratio weighting approach, the direct effect of maternal depression or anxiety in pregnancy is equal to a 59% (95% CI: 27%,94%) increased prevalence of infant wheezing and the mediated effect through adverse reproductive outcomes is equal to a 3% (95% CI:-6%,12%) increased prevalence of infant wheezing. When including infant lower respiratory infections in the mediation pathway, the direct effect decreases to 57% (95% CI: 25%,92%) and the indirect effect increases to 5% (95% CI:-5%,15%). The estimates of the effects obtained using the weighting and the imputation approaches are similar. The extended imputation approach suggests that the small joint indirect effect through adverse reproductive outcomes and lower respiratory infections is due entirely to the contribution of infant lower respiratory infections, independently from the increased prevalence of adverse reproductive outcomes. Conclusions: The four methods revealed similar results of small mediating role of adverse reproductive outcomes and early respiratory tract infections in the effect of maternal pregnancy mental health on infant wheezing. The choice of the method may depend on what is the effect of main interest, the nature of the variables involved in the analysis and the truthfulness of the underlying assumptions.
PENGEMBANGAN MULTIMEDIA PEMBELAJARAN AL-QUR’AN JUZ 30 BERBASIS MUROTTAL
Authors: Cholid Nur Cholid , Muqoffa Durrotul 
Published: May 2022

The development of instruksional multimedia is a technological ddvancement in the world of education. The existence of technological supprot in The field of Education makes teachers assisted in effort to improve the quality of learning and to achieve teaching objective. This study aim to determine : 1) how to make multimedia learning qur’an juz 30 based on murrotal; 2) determine the feasibility of murrotal-based Quran learning multimedia developed as a medium for learning the quran juz 30. This research is a research and development. This development research was carried out throught several stage, namely potential and problem, information gathering, products design, design validation, desain revision. In the validation stage, multimedia learning in the Quran si validated by material experts and media experts. Data collection techniques use are questionnaire for instrumen. The validation data is the converted to a likert scale to obtain a multimedia feasibility category based on murrotal Quran. This research and development has produced murrotal juz-based Quran learning video. Learning multimedia for Quran is feasible to be used in both good and very good categories. This can be seen in the result of validation of material experts with a score of 4.5 or the category of very good; validation of media experts with a score of 3.6 or good category.
Fuzzy credibility-constrained quadratic optimization for booster chlorination of the water distribution system under uncertainty
Authors: Wang Yumin , Zhu Guangcan 
Published: May 2022

Abstract
To keep chlorine concentration at acceptable levels, chlorine is usually injected into the water distribution system (WDS). To protect the health of human beings, the chlorine concentration at consumers’ nodes should be kept at appropriate levels. However, these levels are difficult to determine due to the presence of fuzzy uncertainties. To deal with fuzziness at both sides of the constraints in the optimization model of booster chlorination, we propose a fuzzy credibility-constrained quadratic programming (FCCQP) model with a consideration of credibility levels and weight coefficients. The proposed model is applied to two WDSs to obtain the booster cost under uncertain conditions. The results indicate that the booster cost increases with the confidence level for lower chlorine concentration ζL. In addition, the booster cost decreases with the weight coefficient w. The booster cost function curves along with the variation of weight coefficients are concave and convex for scenario 1 and scenario 2, respectively. These results can help managers to make informed decisions on disinfection injection under conditions of fuzzy uncertainties.
Using microcontroller based solar power system for reliable power supply
Authors: M.M. Shahjalal , Mehedy Manna , Rahman Md. Mijanur , Ali Md. Tuhin , Rahman Md. Mosiur , Bagdadee Amam Hossain 
Published: May 2022

This paper has been demonstrated by implementing renewable energy-based solar power for a reliable power supply controlled by the Node MCU microcontroller. The microcontroller is controlled the system by programming. Here also use an inverter, Node MCU, Battery, Solar Charge Controller. The main task of this Scheme is that when the sun reflects on this solar panel, it will charge and save its battery. Two AC loads will run from the battery to the inverter, which can control via the Internet. DC will be converted to AC through the inverter and load. The main objective of this research is to use solar sources for load control and monitoring through the Internet.
Glomerular Exostosin as a Subtype and Activity Marker of Class 5 Lupus Nephritis
Authors: Wang Chengyu , Liu Yang , Zhang Mingchao , Yang Fan , Xu Feng , Shi Shaolin , Zeng Caihong , Chen Xin , Miao Yiqi , Liu Zhengzhao , Hu Weixin 
Published: May 2022

Background and objectives
There have been only several studies on the correlation between glomerular exostosin expression and membranous lupus nephritis. In this study, we validate the previous findings in Chinese patients with class 5 lupus nephritis.

Design, setting, participants, & measure
One hundred sixty-five patients with class 5 lupus nephritis and varying numbers of control patients were included. Exostosin1/exostosin2 staining was performed by immunohistochemistry, and the staining intensity was quantified using an imaging analysis system. Between-group comparisons were tested for statistical significance using the Pearson chi-squared test, the Fisher exact test, the unpaired t test, the Mann–Whitney U test, or one-way ANOVA.

Results
In total, 46% of patients with class 5 lupus nephritis, 9% of patients with class 5 + 3/4 lupus nephritis, and none of the other classes of lupus nephritis were exostosin positive. Only three patients were exostosin positive among the 61 patients with other secondary membranous nephropathy. The exostosin-positive rate in nephrotic patients was significantly higher than that in patients without nephrotic syndrome (P<0.001), and the exostosin staining intensities of the patients with exostosin-positive class 5 were positively correlated with proteinuria (r=0.53; P<0.001). Compared with the patients with exostosin-negative cases, the patients with exostosin-positive cases had higher proteinuria levels (3.9 [interquartile range, 2.0–6.3] g/d versus 2.3 [interquartile range, 1.0–3.6] g/d; P<0.001); lower scores of activity index (1 [interquartile range, 1–2] versus 2 [interquartile range, 1–3]; P=0.001), chronicity index (1 [interquartile range, 0–2] versus 2 [interquartile range, 1–2]; P=0.02), and tubular atrophy score (0 [interquartile range, 0–1] versus 1 [interquartile range, 0–1]; P=0.008); a higher proportion of extensive subepithelial deposition (62% versus 27%; P<0.001); a similar treatment response; and comparable time to kidney end point. Among the 47 patients with class 5 who underwent repeat biopsy, 97% of those with exostosin-negative cases remained negative, whereas 44% of those with exostosin-positive cases were still positive. The rate of histologic transition in the patients with exostosin-negative class 5 was significantly higher than that in the patients with exostosin-positive class 5 (59% versus 22%; P=0.03).

Conclusions
Exostosin positivity occurred frequently in patients with class 5 lupus nephritis, and patients with exostosin-positive cases had more severe proteinuria and a lower rate of histologic transition than the exostosin-negative patients.
A Measure of Firm Complexity: Data and Code
Authors: Hoitash Rani , Hoitash Udi 
Published: May 2022

ABSTRACT
We propose that firm complexity is best measured with accounting disclosures. Accounting is the “language of business,” and accounting disclosures of most business activities are mandated. Therefore, relying on accounting disclosures is the best approach for consistently capturing a wide range of firm activities for a large cross-section of firms. Measuring firm complexity is important for many applications in research and practice. However, firm complexity is multifaceted, making it difficult to measure. We review past research on complexity and motivate the use of Accounting Reporting Complexity (ARC), proposed by R. Hoitash and U. Hoitash (2018), to measure firm complexity. In so doing, we discuss the advantages of ARC over other measures. We then review studies that use ARC and provide a detailed description and code to construct ARC (and related measures) based on publicly available data. The complete ARC dataset is also available for download at: https://www.xbrlresearch.com/.
Data Availability: Data are publicly available from sources identified in the paper. ARC is based on XBRL filings downloaded directly from the Securities and Exchange Commission and is available for download at: https://www.xbrlresearch.com/.
JEL Classifications: B40; D20; C10; G10; L25; M40.
Orders Backlog in Earnings Conference Calls
Authors: Feldman Ronen , Govindaraj Suresh , Livnat Joshua , Suslava Kate 
Published: May 2022

ABSTRACT
Focusing on quarterly earnings conference call transcripts, we provide evidence that order backlog discussions are positively priced by investors. Pricing appears to be efficient whether these discussions are accompanied by quantitative support or are solely qualitative. We find these disclosures to have stronger pricing effects for growth firms and firms with weaker information environments. Our study contributes to the body of order backlog research by incorporating more timely disclosures as well as by incorporating qualitative disclosures.
Data Availability: Data used in this study are available from public sources identified in the study.
JEL Classifications: G14; M41.
Plasma Adrenomedullin, Allelic Variations in the ADM Gene, and Risk for Lower-Limb Amputation in People With Type 2 Diabetes
Authors: Potier Louis , Mohammedi Kamel , Saulnier Pierre-Jean , Fumeron Frédéric , Halimi Jean-Michel , Venteclef Nicolas , Marre Michel , Hadjadj Samy , Roussel Ronan , Velho Gilberto 
Published: May 2022

OBJECTIVE
Patients with diabetes have an increased risk for lower-limb amputation (LLA), but biomarkers to assess risk of LLA are lacking. Adrenomedullin (ADM) is a vasodilator peptide that also plays a role in fluid and electrolyte homeostasis in the kidney, increasing natriuresis and diuresis. ADM was shown to be associated with cardiovascular and renal events in diabetes, but it was not investigated in terms of LLA risk. We investigated the hypothesis that ADM is associated with LLA in people with type 2 diabetes.

RESEARCH DESIGN AND METHODS
We studied 4,375 participants in the DIABHYCAR and SURDIAGENE cohorts (men, 68%; mean 66 years of age; mean duration of diabetes 12 years; and median follow-up 5.3 years). Plasma midregional proadrenomedullin (MR-proADM; a surrogate for ADM) was measured by immunofluorescence. Five single nucleotide polymorphisms (SNPs) in the ADM gene region were genotyped.

RESULTS
LLA requirement during follow-up by increasing tertiles of plasma MR-proADM distribution was 1.0% (tertile 1 [T1]), 2.3% (T2), and 4.4% (T3) (P &lt; 0.0001). In Cox multivariate analysis, the adjusted hazard ratio (95% CI) for LLA was 4.40 (2.30–8.88) (P &lt; 0.0001) for T3 versus T1. Moreover, MR-proADM significantly improved indices for risk stratification of LLA. Four SNPs were associated with plasma MR-proADM concentration at baseline and with LLA during follow-up. Alleles associated with higher MR-proADM were associated with increased LLA risk.

CONCLUSIONS
We observed associations of plasma MR-proADM with LLA and of ADM SNPs with plasma MR-proADM and with LLA in people with type 2 diabetes. This pattern of Mendelian randomization supports the causality of the association of ADM with LLA.
NaOCl Application after Acid Etching and Retention of Cervical Restorations: A 3-Year Randomized Clinical Trial
Authors: Favetti M , Schroeder T , Montagner AF , Moraes RR , Pereira-Cenci T , Cenci MS 
Published: May 2022

SUMMARY
This study evaluated the retention of composite resin restorations in noncarious cervical lesions (NCCLs) performed with or without pretreatment with 10% NaOCl solution (deproteinization). A randomized, controlled, split-mouth, double-blinded trial was carried out. Thirty patients with at least two NCCLs were included in the study. The NCCLs were randomly allocated into two treatment groups: control (acid etching with 37% phosphoric acid + placebo solution + Adper Single Bond 2/3M Oral Care + Filtek Z350/3M Oral Care) or experimental group (acid etching with 37% phosphoric acid + 10% NaOCl solution + Adper Single Bond 2 + Filtek Z350). A calibrated examiner evaluated the restorations at baseline (1 week) and recalls (6, 12, 24, and 36 months) using the FDI criteria. The primary outcome evaluated was retention of the restorations. Data were analyzed by the Kaplan-Meier method and the log-rank test (α=0.05). After 3 years, 64 restorations were evaluated in 23 patients. The annual failure rate was 9% for the control group and 17.8% for the experimental group (deproteinization technique). Considering the failures and their distribution among the characteristics of the patients and NCCLs, no statistically significant differences were observed for the control and experimental treatment groups (p=0.077) or the number of teeth in the mouth (p=0.320). Restorations in the mandible (p=0.039) and premolars (p=0.013) showed significantly lower clinical survival rates. The deproteinization pretreatment with a 10% NaOCl solution did not promote additional retention of restorations in NCCLs. (clinicaltrials. gov: NCT03086720)
Arkytectura. Espacio abierto de arquitectura. Revista Digital www.espacioabiertodearquitectura.com
Authors: Díaz Pardo José Ignacio , Gómez Millón Olga 
Published: May 2022

Fines e intenciones.- Es una revista digital destinada a informar y educar en el conocimiento de la arquitectura contemporánea, enfocada a situarse en el contexto de las corrientes internacionales en el actual marco histórico.
Destinatarios.- Los profesionales, investigadores, críticos y estudiosos de la Arquitectura y de los clientes y consumidores o usuarios de los productos arquitectónicos.