bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mind the gap: avoiding paravalvular leak using computer simulation in bicuspid transcatheter aortic valve replacement—a case report
Authors: Dargan James , Hampal Rumneek , Khan Faisal , Brecker Stephen 
Published: September 2022

Abstract

Background
Transcatheter aortic valve replacement (TAVR) is becoming increasingly prevalent worldwide and is now more common than surgical aortic valve replacement. It is expanding into all patient subsets including younger and lower risk patients. Bicuspid aortic valve (BAV) accounts for a significant proportion of TAVR, but due to heterogenous anatomy, it is of increased complexity. One of the greatest challenges in BAV is the selection of the correct TAVR size. Transcatheter aortic valve replacement sizing is based upon computed tomography–derived annular measurements. There are a number of sizing algorithms for BAV based upon anatomical characteristics, often yielding different results. This is noted especially when a patient falls near the borderline between two valve sizes, an anatomical grey zone. Complementary to the algorithm approach is the use of pre-procedural patient-specific computer simulation using finite-element modelling.

Case summary
An 86-year-old female was treated for heart failure secondary to severe and calcific BAV aortic stenosis with TAVR. Due to anatomical difficulty and grey-zone valve sizing, we demonstrate the use of pre-procedural patient-specific computer simulation with the novel Medtronic Evolut PRO+ platform to achieve a good result.

Discussion
Using patient-specific computer simulation, we were able to safely select the valve and the deployment height and then accurately predict the result in a difficult, severely calcified BAV. In addition to improving outcome, this allows for patient-specific, tailored discussion to occur at heart team meetings.
Valvular heart disease: shifting the focus to the myocardium
Authors: Ajmone Marsan Nina , Delgado Victoria , Shah Dipan J , Pellikka Patricia , Bax Jeroen J , Treibel Thomas , Cavalcante João L 
Published: September 2022

Abstract
Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative valvular heart disease (VHD). However, to give an indication for valvular intervention, current guidelines include parameters of cardiac chamber dilatation or function which are subject to variability, do not directly reflect myocardial structural changes, and, more importantly, seem to be not sensitive enough in depicting early signs of myocardial dysfunction before irreversible myocardial damage has occurred. To avoid irreversible myocardial dysfunction, novel biomarkers are advocated to help refining indications for intervention and risk stratification. Advanced echocardiographic modalities, including strain analysis, and magnetic resonance imaging have shown to be promising in providing new tools to depict the important switch from adaptive to maladaptive myocardial changes in response to severe VHD. This review, therefore, summarizes the current available evidence on the role of these new imaging biomarkers in degenerative VHD, aiming at shifting the clinical perspective from a valve-centred to a myocardium-focused approach for patient management and therapeutic decision-making.
A cost analysis of a sports-based sexual health education programme for adolescent girls in South African schools
Authors: Bango Funeka , Pike Carey , Coakley Chelsea , Bekker Linda-Gail , Cleary Susan 
Published: September 2022

Abstract
Studies have shown that school-based sexual health promotion interventions can improve adolescent sexual and reproductive health outcomes. However, there has been insufficient evidence on the cost and cost-effectiveness of such programmes, driving poor and inconsistent investment and prioritization. This paper analyses the costs of the SKILLZ Health for Girls programme, a sports-based sexual education intervention targeted at adolescent girls in the secondary school environment. Costs were collected alongside a cluster-randomized trial, including 38 secondary schools in Cape Town, South Africa. The analysis was conducted from a provider (multi-sector) perspective and used a mixed-methods costing approach. We developed a cost data collection tool to compile cost information from one-on-one interviews, administrative data and non-participant observations of the intervention. Costs were analysed for 2019, representing a full academic year of programme implementation. The intention-to-treat analysis revealed an average cost per learner per session of $9.92, and the cost per learner reached was estimated at $69.43. Sensitivity analysis indicated that these costs were sensitive to the participation rates of the learners who did not complete the intervention. The cumulative cost for the scale-up scenario for the Western Cape Province based on the base-case analysis (maximizing coverage of schools but only including 30% of eligible learners within schools) was estimated at $5 311 453.00 for a 3-year period, which exceeds the provincial conditional grant allocation dedicated to the human immunodeficiency virus and acquired immune deficiency syndrome (life skills education) for the same period, yet is comparable to the expenditure for a similar donor-funded programme within the province. The study’s results will contribute to decision-making for implementing sexual education interventions in schools in South Africa and similar contexts.
Genome-wide characterization of the tomato GASA family identifies SlGASA1 as a repressor of fruit ripening
Authors: Su Dan , Liu Kaidong , Yu Zhuoshu , Li Ying , Zhang Yaoxin , Zhu Yunqi , Wu Yi , He Hongyu , Zeng Xiaodan , Chen Honglin , Grierson Don , Deng Heng , Liu Mingchun 
Published: September 2022

AbstractGibberellins (GAs) play crucial roles in a wide range of developmental processes and stress responses in plants. However, the roles of GA-responsive genes in tomato (Solanum lycopersicum) fruit development remain largely unknown. Here, we identify 17 GASA (Gibberellic Acid-Stimulated Arabidopsis) family genes in tomato. These genes encode proteins with a cleavable signal peptide at their N terminus and a conserved GASA domain at their C terminus. The expression levels of all tomato GASA family genes were responsive to exogenous GA treatment, but adding ethylene eliminated this effect. Comprehensive expression profiling of SlGASA family genes showed that SlGASA1 follows a ripening-associated expression pattern, with low expression levels during fruit ripening, suggesting it plays a negative role in regulating ripening. Overexpressing SlGASA1 using a ripening-specific promoter delayed the onset of fruit ripening, whereas SlGASA1-knockdown fruits displayed accelerated ripening. Consistent with their delayed ripening, SlGASA1-overexpressing fruits showed significantly reduced ethylene production and carotenoid contents compared to the wild type. Moreover, ripening-related genes were downregulated in SlGASA1-overexpressing fruits but upregulated in SlGASA1-knockdown fruits compared to the wild type. Yeast two-hybrid, co-immunoprecipitation, transactivation, and DNA pull-down assays indicated that SlGASA1 interacts with the key ripening regulator FRUITFULL1 and represses its activation of the ethylene biosynthesis genes ACS2 and ACO1. Our findings shed new light on the role and mode of action of a GA-responsive gene in tomato fruit ripening.
Mortality of Bark- and Wood-boring Beetles (Coleoptera: Buprestidae, Cerambycidae, and Curculionidae) in Naturally Infested Heat-treated Ash, Birch, Oak, and Pine Bolts
Authors: Haack Robert A , Petrice Toby R 
Published: September 2022

AbstractFirewood and wood packaging material (WPM) are major pathways for moving bark- and wood-infesting insects (borers). Heat treatment regulations for interstate firewood movement vary among U.S. states: from 56°C for 30 min to 71.1°C for 75 min. Current WPM international standards (ISPM 15) require heating to a minimum of 56°C for 30 min throughout the profile of the wood. Using bolts from infested ash (Fraxinus), birch (Betula), oak (Quercus), and pine (Pinus) trees in Michigan, we assessed borer mortality at core temperatures of 50, 53, 56, and 60°C maintained for 30 min in chambers set to 60, 65, 70, or 75°C. After treatment, bolts were monitored for adult emergence and later dissected to determine borer mortality rates. Mortality was high to complete for all heat treatments and increased with both increasing core and chamber temperatures. For the Agrilus (Buprestidae) species tested, there was complete mortality of Agrilus anxius on birch and Agrilus planipennis on ash when core temperatures of 56°C or higher were targeted regardless of chamber temperature. However, on oak, a few Agrilus bilineatus and Agrilus sulcicollis survived in bolts heated to 56°C in chambers at 60 and 65°C, and some A. sulcicollis survived in chambers set at 70 and 75°C. Similarly, a few pine-infesting borers survived heating to 56°C at all chamber temperatures. However, there was complete mortality in all hosts when bolts were heated to 60°C for 30 min, regardless of chamber temperature. Results are discussed in terms of current treatment regulations for firewood and WPM.
Wordsworth and the World: Teaching Postsecular Romanticism in the Humanities
Authors: Tomko Michael 
Published: September 2022

Abstract
Drawing on William Wordsworth’s sonnet, ‘The world is too much with us’, as a case study, I consider the ways that the longstanding assumptions of the secularisation thesis from M.H. Abrams and elsewhere have framed anthologies and syllabi of Romantic literary studies. Such structural constraints have limited the theological readings of Romanticism that can be plausible in the classroom, regardless of the nuance and complexity of postsecular research and theory emerging across 19th-century scholarship. Departing from a disciplinary literature classroom as its default, I discuss the broader and more vibrant possibilities for rereading Wordsworth’s sonnet within Villanova University’s innovative Humanities department, whose interdisciplinary and question-driven curriculum keeps theological and philosophical inquiries open and alive. Further, its syllabi pair Wordsworth with voices ranging from St Augustine to Howard Thurman to Abraham Heschel. Such an educational setting allows for attunement to possible ways that the frustrated lyric voice still feels a spiritual call towards the supernatural in nature despite the imminent discourses of the age—a romantic revision that reopens horizons for both teaching and scholarship.
Complexity of injection structures induced by finite state transducers
Authors: Krogman Richard , Cenzer Douglas 
Published: September 2022

Abstract
An injection structure ${{\mathcal {A}}} = (A,f)$ is a set $A$ together with a one-place one-to-one function $f$. ${{\mathcal {A}}}$ is a Finite State Transducer (abbreviated FST) injection structure if $A$ is a regular set, i.e. the set of words accepted by some finite automaton, and $f$ is realized by a deterministic FST. We study the complexity of the character of an FST injection structure. We examine the effective categoricity of such structures. We show that the isomorphism problem for unary FST structures is decidable in quadratic time.
The Cluster Ages Experiment (CASE) – IX. Analysis of four detached eclipsing binaries in the globular cluster NGC 3201
Authors: Rozyczka M , Thompson I B , Dotter A , Mazur B , Narloch W , Pych W , Hełminiak K G , Moharana A , Beletsky Y , Burley G S , Marshall J L , Morrell N , Osip D , Shectman S A , Bernstein R , Pilecki B , Zgirski B 
Published: September 2022

ABSTRACT
We use photometric and spectroscopic observations of four detached eclipsing binaries in the globular cluster NGC 3201 to derive masses, radii, and luminosities of the component stars. Spanning across almost three magnitudes in the colour–magnitude diagram, the components offer a unique possibility to test the theory of stellar evolution. Their masses, radii, and luminosities range from 0.66 to 0.84 M⊙, 0.68 to 2.46 R⊙, and 0.38 to 5.56 L⊙, respectively. The distance to the cluster measured from the distance moduli of the component stars amounts to 4.54$^{+0.11}_{-0.14}$ kpc and agrees with the recent estimate based on Gaia parallaxes. By comparing the M − R and M − L diagrams of the component stars and the colour–magnitude diagram of NGC 3201 to Dartmouth model isochrones, we estimate the most probable age of the cluster to be 11.5 ± 0.5 Gyr. This estimate is based on three binaries only, as the fourth one seems to evolve along a different path, probably due to non-standard chemical composition and/or history. We confirm the tendency, observed in earlier CASE papers, for the age indicated by the M − R diagram to be younger than that implied by the colour–magnitude diagram.
Density waves in protoplanetary discs excited by eccentric planets: linear theory
Authors: Fairbairn Callum W , Rafikov Roman R 
Published: September 2022

ABSTRACT
Spiral density waves observed in protoplanetary discs have often been used to infer the presence of embedded planets. This inference relies both on simulations as well as the linear theory of planet–disc interaction developed for planets on circular orbits to predict the morphology of the density wake. In this work, we develop and implement a linear framework for calculating the structure of the density wave in a gaseous disc driven by an eccentric planet. Our approach takes into account both the essential azimuthal and temporal periodicities of the problem, allowing us to treat any periodic perturbing potential (i.e. not only that of an eccentric planet). We test our framework by calculating the morphology of the density waves excited by an eccentric, low-mass planet embedded in a globally isothermal disc and compare our results to the recent direct numerical simulations (and heuristic wavelet analysis) of the same problem by Zhu and Zhang. We find excellent agreement with the numerical simulations, capturing all the complex eccentric features including spiral bifurcations, wave crossings, and planet-wave detachments, with improved accuracy and detail compared with the wavelet method. This illustrates the power of our linear framework in reproducing the morphology of complicated time-dependent density wakes, presenting it as a valuable tool for future studies of eccentric planet–disc interactions.
Eclipse Timings of the LMXB XTE J1710−281 : discovery of a third orbital period glitch
Authors: Jain Chetana , Sharma Rahul , Paul Biswajit 
Published: September 2022

ABSTRACT
We present an updated measurement of orbital period evolution of LMXB XTE J1710−281 by using eclipse timing technique. Using data obtained with XMM-Newton, Suzaku, RXTE, Chandra, and AstroSat observatories, we report 21 new measurements of X-ray mid-eclipse times. We have discovered a third orbital period glitch in XTE J1710−281 with an F-test false alarm probability of ∼0.7 per cent for occurrence of the third glitch and report detection of four distinct epochs of orbital period in this system. This work presents a more robust estimation of occurrence of the second orbital period glitch. However, the epoch of occurrence of the third glitch is poorly constrained, between MJD 55726 and 56402. We have put lower limits of 1.48, 0.97, and 0.45 ms, on sudden changes in orbital period between the successive epochs. We discuss the implications of our findings in context of magnetic nature of the companion star and possible scattering events with circumbinary objects around this binary system.
The simultaneity of emission from approaching and receding jets
Authors: Maccarone Thomas J , Pattie Eli C , Tetarenko Alexandra J 
Published: September 2022

ABSTRACT
We show that the standard Blandford–Königl model for compact conical relativistic jets has a peculiar feature: At a given observed frequency of radiation, the emission from the approaching jet arrives at the location of a distant observer at the same time as the emission from the counterjet for all finite inclination angles. We show that this result can be used to determine whether jets are genuinely symmetric, if the cross-coherence between radio and X-ray time series can be measured at high Fourier frequency for a sample of neutron star X-ray binaries with a range of inclination angles. We also discuss echo mapping techniques that can be used to look for deviations from the standard model in high cadence time series data on X-ray binary jets, and conclude that these can plausibly be applied to some systems.
Functional integration of a semi-synthetic azido-queuosine derivative into translation and a tRNA modification circuit
Authors: Bessler Larissa , Kaur Navpreet , Vogt Lea-Marie , Flemmich Laurin , Siebenaller Carmen , Winz Marie-Luise , Tuorto Francesca , Micura Ronald , Ehrenhofer-Murray Ann E , Helm Mark 
Published: September 2022

Abstract
Substitution of the queuine nucleobase precursor preQ1 by an azide-containing derivative (azido-propyl-preQ1) led to incorporation of this clickable chemical entity into tRNA via transglycosylation in vitro as well as in vivo in Escherichia coli, Schizosaccharomyces pombe and human cells. The resulting semi-synthetic RNA modification, here termed Q-L1, was present in tRNAs on actively translating ribosomes, indicating functional integration into aminoacylation and recruitment to the ribosome. The azide moiety of Q-L1 facilitates analytics via click conjugation of a fluorescent dye, or of biotin for affinity purification. Combining the latter with RNAseq showed that TGT maintained its native tRNA substrate specificity in S. pombe cells. The semi-synthetic tRNA modification Q-L1 was also functional in tRNA maturation, in effectively replacing the natural queuosine in its stimulation of further modification of tRNAAsp with 5-methylcytosine at position 38 by the tRNA methyltransferase Dnmt2 in S. pombe. This is the first demonstrated in vivo integration of a synthetic moiety into an RNA modification circuit, where one RNA modification stimulates another. In summary, the scarcity of queuosinylation sites in cellular RNA, makes our synthetic q/Q system a ‘minimally invasive’ system for placement of a non-natural, clickable nucleobase within the total cellular RNA.
ProPan: a comprehensive database for profiling prokaryotic pan-genome dynamics
Authors: Zhang Yadong , Zhang Hao , Zhang Zaichao , Qian Qiheng , Zhang Zhewen , Xiao Jingfa 
Published: September 2022

Abstract
Compared with conventional comparative genomics, the recent studies in pan-genomics have provided further insights into species genomic dynamics, taxonomy and identification, pathogenicity and environmental adaptation. To better understand genome characteristics of species of interest and to fully excavate key metabolic and resistant genes and their conservations and variations, here we present ProPan (https://ngdc.cncb.ac.cn/propan), a public database covering 23 archaeal species and 1,481 bacterial species (in a total of 51,882 strains) for comprehensively profiling prokaryotic pan-genome dynamics. By analyzing and integrating these massive datasets, ProPan offers three major aspects for the pan-genome dynamics of the species of interest: 1) the evaluations of various species' characteristics and composition in pan-genome dynamics; 2) the visualization of map association, the functional annotation and presence/absence variation for all contained species' gene clusters; 3) the typical characteristics of the environmental adaptation, including resistance genes prediction of 126 substances (biocide, antimicrobial drug and metal) and evaluation of 31 metabolic cycle processes. Besides, ProPan develops a very user-friendly interface, flexible retrieval and multi-level real-time statistical visualization. Taken together, ProPan will serve as a weighty resource for the studies of prokaryotic pan-genome dynamics, taxonomy and identification as well as environmental adaptation.
Implementing targeted therapies in the treatment of glioblastoma: Previous shortcomings, future promises, and a multimodal strategy recommendation
Authors: Fougner Vincent , Hasselbalch Benedikte , Lassen Ulrik , Weischenfeldt Joachim , Poulsen Hans Skovgaard , Urup Thomas 
Published: September 2022

AbstractThe introduction of targeted therapies to the field of oncology has prolonged the survival of several tumor types. Despite extensive research and numerous trials, similar outcomes have unfortunately not been realized for glioblastoma. For more than 15 years, the standard treatment of glioblastoma has been unchanged. This review walks through the elements that have challenged the success of previous trials and highlight some future promises. Concurrently, this review describes how institutions, through a multimodal and comprehensive strategy with 4 essential components, may increase the probability of finding a meaningful role for targeted therapies in the treatment of glioblastoma. These components are (1) prudent trial designs, (2) considered drug and target selection, (3) harnessed real-world clinical and molecular evidence, and (4) incorporation of translational research.
Natural products and drug discovery
Authors: Newman David J 
Published: September 2022

Abstract
This review covers the recent history of a series of very important natural products and their derivatives that are currently in use or under evaluation in the areas of anti-infectives, important cancer treatments that include antibody drug conjugates, followed by a discussion of type 2 diabetes (T2DM) drugs and angiotensin converting enzyme inhibitors. The current structures of the agents are shown, though in the case of some peptides used in T2DM drugs the standard single letter abbreviation for an amino acid is used.
Climate change effects on mental health: are there workplace implications?
Authors: Brooks S K , Greenberg N 
Published: September 2022

Abstract

Background
Climate change can negatively affect mental health, and poor mental health can negatively affect work. However, less is known about the relationship between mental health and workplace behaviours within the climate change context.

Aims
To explore existing literature relating to climate-induced mental ill-health as a potential predictor of workplace behaviours.

Methods
Scoping review, searching five databases for relevant literature using two separate search strategies.

Results
Only five studies with any relevant data were found. Results could not be easily synthesized because each of the five considered different work-related outcomes. However, the available data suggest that the psychological impact of extreme events could lead to increased job tension, higher turnover intentions and workplace hostility. Stress about extreme weather could also impede the ability to make essential work-related decisions and, for those who work in the environmental sector, concerns about climate could lead to overcommitment to work. There was some evidence that social support might lessen the effects of climate-induced stress on work outcomes.

Conclusions
Very little literature considers the impacts of climate change on employees’ mental health and associated workplace function. The available evidence suggests there are potential negative impacts which may be mitigated by social support. It is important for future research to explore ways of supporting staff and fostering resilience.