bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pursuing the Individual in Working-Class History
Authors: Barrett James R. 
Published: August 2022

AbstractThe individual is still rare in working-class history, and, when we find them, they are often, like Bebel and Lula, exceptional. We are interested in them as leaders of vital mass movements and because they had an important impact on their societies. But another part of the promise of biographies like these is the opportunity to approach the personal dimensions of working-class experience through an individual life. Bringing the two biographies together highlights the diversity of working-class experience. Bebel developed in a racially homogeneous society while Lula was a mixed-race person shaped in race-conscious Brazil. Bebel thrived as a small-shop artisan while Lula thrived as a skilled worker in a mass production factory. I also compare and contrast these two subjects with two American labor radicals, the socialist leader Eugene Debs and William Z. Foster, a key figure in the Communist Party of the US. The importance of individual psychology and the homosocial worlds of these subjects might have played a greater role here, while the ubiquitous learning of both men raises the problem of working-class intellectual history, another subject that has not received enough attention from labor historians.
Executive function as a generalized determinant of psychopathology and functional outcome in school-aged autism spectrum disorder: a case-control study
Authors: Wong Oscar W. H. , Barzilay Ran , Lam Angela M. W. , Chan Sandra , Calkins Monica E. , Gur Raquel E. , Gur Ruben C. 
Published: August 2022

AbstractBackgroundIndividuals with autism spectrum disorder (ASD) are challenged not only by the defining features of social-communication deficits and restricted repetitive behaviors, but also by a myriad of psychopathology varying in severity. Different cognitive deficits underpin these psychopathologies, which could be subjected to intervention to alter the course of the disorder. Understanding domain-specific mediating effects of cognition is essential for developing targeted intervention strategies. However, the high degree of inter-correlation among different cognitive functions hinders elucidation of individual effects.MethodsIn the Philadelphia Neurodevelopmental Cohort, 218 individuals with ASD were matched with 872 non-ASD controls on sex, age, race, and socioeconomic status. Participants of this cohort were deeply and broadly phenotyped on neurocognitive abilities and dimensional psychopathology. Using structural equation modeling, inter-correlation among cognitive domains were adjusted before mediation analysis on outcomes of multi-domain psychopathology and functional level.ResultsWhile social cognition, complex cognition, and memory each had a unique pattern of mediating effect on psychopathology domains in ASD, none had significant effects on the functional level. In contrast, executive function was the only cognitive domain that exerted a generalized negative impact on every psychopathology domain (p factor, anxious-misery, psychosis, fear, and externalizing), as well as functional level.ConclusionsExecutive function has a unique association with the severity of comorbid psychopathology in ASD, and could be a target of interventions. As executive dysfunction occurs variably in ASD, our result also supports the clinical utility of assessing executive function for prognostic purposes.
Who Should Represent Future Generations in Climate Planning?
Authors: Byskov Morten Fibieger , Hyams Keith 
Published: August 2022

AbstractExtreme impacts from climate change are already being felt around the world. The policy choices that we make now will affect not only how high global temperatures rise but also how well-equipped future economies and infrastructures are to cope with these changes. The interests of future generations must therefore be central to climate policy and practice. This raises the questions:Whoshould represent the interests of future generations with respect to climate change? And according to whichcriteriashould we judge whether a particular candidate would make an appropriate representative for future generations? In this essay, we argue that potential representatives of future generations should satisfy what we call a “hypothetical acceptance criterion,” which requires that the representative could reasonably be expected to be accepted by future generations. This overarching criterion in turn gives rise to two derivative criteria. These are, first, the representative'sepistemic and experiential similarity to future generations, and second, his or hermotivation to act on behalf of future generations. We conclude that communities already adversely affected by climate change best satisfy these criteria and are therefore able to command the hypothetical acceptance of future generations.
Communities and Climate Change: Why Practices and Practitioners Matter
Authors: Grix Marco , Watene Krushil 
Published: August 2022

AbstractCommunities most vulnerable to the effects of climate change, such as reduced access to material resources and increased exposure to adverse weather conditions, are intimately tied to a considerable amount of cultural and biological diversity on our planet. Much of that diversity is bound up in the social practices of Indigenous groups, which is why these practices have great long-term value. Yet, little attention has been given to them by philosophers. Also neglected have been the historical conditions and contemporary realities that constrain these practices and devalue the knowledge of their practitioners. In this essay, we make the case for preserving a diverse range of social practices worldwide, and we argue that this is possible only by strengthening the communities of practitioners who enact them in the contexts in which they are adaptive. By concentrating on Indigenous communities, we show how focusing on practices can transform how Indigenous and other local communities are represented in global climate-change conversations and policy as a matter of justice. More specifically, we argue that practice-centered thinking and local practices provide critical insights for determining the extent to which climate policies protect and enable transformative change.
A neonate with crossed pulmonary arteries: a case report and literature review of 115 cases worldwide
Authors: Alhassan Abdalrahman A. , Shati Ayed A. , Al-Ahmari Sami M. , Elhadam Afia E. , Bushari Tajudeen M. , Elhag Omer H. , Elhoury Motea E. 
Published: August 2022

AbstractMalposition of the branch pulmonary arteries (MBPA) is an unusual malformation characterised by anomalous origin of both pulmonary arteries from the main pulmonary trunk. To date, only few cases have been reported. Herein, we present the first case report of a 3-day-old, full-term male neonate with the lesser form of crossed pulmonary arteries in Saudi Arabia detected by echocardiography and confirmed by cardiac CT. Crossed pulmonary arteries is not a rare anomaly, but it is a somewhat underreported anomaly, and their recognition is important because it is usually associated with other CHDs, airway obstruction, extra-cardiac anomalies, and certain genetic syndromes.
Speaking Machines, the Trial of Articulation, and Deaf Education in Modern France
Authors: Arnaud Sabine 
Published: August 2022

AbstractIf cochlear implants continue to meet with much resistance from parts of the Deaf community and beyond, this reflects constructions of speech that have been at the core of conceptions of humankind for over three centuries. Starting in the 1750s, Julien Offray de La Mettrie advocated for deaf people's potential for speech. This was also the time of the creation of schools for deaf children, which led to a surge of debate about teaching sign language versus speech. The reception of the speaking machine of Canon Mical, a now forgotten inventor, offered another context in which to question the source of the expressive power of language. By retracing debates about the mechanical nature of articulated speech, the potential limits of communication, and what really constitutes its expressive power, we can better understand how the experience of current technology develops out of conflicts first introduced at the birth of modernity.
Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality
Authors: Ahmadi Matthew N. , Lee I-Min , Hamer Mark , del Pozo Cruz Borja , Chen Li Jung , Eroglu Elif , Lai Yun-Ju , Ku Po Wen , Stamatakis Emmanuel 
Published: August 2022

AbstractBackgroundThe relationship between joint changes in physical activity and adiposity with mortality is not well understood. We examined the association of changes in these two established risk factors with all-cause (ACM), cardiovascular disease (CVD), and cancer mortality.MethodsWe used longitudinal data from Taiwan’s MJ Cohort, comprising 116,228 general population adults recruited from 1998-2013 with repeated measures 4.6 y (2.5) apart and followed up for mortality for 11.9 y (3.5). Physical activity, body mass index (BMI), waist circumference (WC), and body fat percentage (BF%) groups and changes were based on public health and clinical guidelines.ResultsCompared to stable-insufficient physical activity, increasing physical activity from any baseline level was associated with lower ACM (HR [95%CI]): 0.85 [0.74, 0.96]) and CVD mortality (0.72 [0.55, 0.93]) risk. This was approximately equal to meeting physical activity guidelines at both timepoints (eg: 0.71 [0.58, 0.88] for CVD mortality). Compared to stable-overweight/moderate adiposity, decreasing adiposity level attenuated but did not offset mortality risk for all three outcomes (eg: BMI = 0.95 [0.76, 1.16] for CVD mortality). Only maintaining a healthy adiposity level at both timepoints offset mortality risk (BMI = 0.75 [0.61, 0.89]) for CVD mortality). In the joint changes analyses, lower mortality risk was a consequence of increases in physical activity across adiposity change groups (eg: WC decrease = 0.57 [0.48, 0.67]; WC stability = 0.73 [0.66, 0.80], WC increase = 0.83 [0.72, 0.97] for ACM). Decreasing adiposity attenuated the negative associations of decreased physical activity (BF% = 1.13 [0.95, 1.35] for ACM).ConclusionsWe found a lower risk for ACM, CVD, and cancer mortality from increasing physical activity and an attenuation from decreasing adiposity regardless of baseline levels. The beneficial associations of joint changes were primarily driven by physical activity, suggesting lower mortality risk may be more immediate through physical activity improvements compared to adiposity improvements alone.
Chemotaxis may assist marine heterotrophic bacterial diazotrophs to find microzones suitable for N2 fixation in the pelagic ocean
Authors: Hallstrøm Søren , Raina Jean-Baptiste , Ostrowski Martin , Parks Donovan H , Tyson Gene W , Hugenholtz Philip , Stocker Roman , Seymour Justin R , Riemann Lasse 
Published: August 2022

Abstract
Heterotrophic bacterial diazotrophs (HBDs) are ubiquitous in the pelagic ocean, where they have been predicted to carry out the anaerobic process of nitrogen fixation within low-oxygen microenvironments associated with marine pelagic particles. However, the mechanisms enabling particle colonization by HBDs are unknown. We hypothesized that HBDs use chemotaxis to locate and colonize suitable microenvironments, and showed that a cultivated marine HBD is chemotactic toward amino acids and phytoplankton-derived DOM. Using an in situ chemotaxis assay, we also discovered that diverse HBDs at a coastal site are motile and chemotactic toward DOM from various phytoplankton taxa and, indeed, that the proportion of diazotrophs was up to seven times higher among the motile fraction of the bacterial community compared to the bulk seawater community. Finally, three of four HBD isolates and 16 of 17 HBD metagenome assembled genomes, recovered from major ocean basins and locations along the Australian coast, each encoded &gt;85% of proteins affiliated with the bacterial chemotaxis pathway. These results document the widespread capacity for chemotaxis in diverse and globally relevant marine HBDs. We suggest that HBDs could use chemotaxis to seek out and colonize low-oxygen microenvironments suitable for nitrogen fixation, such as those formed on marine particles. Chemotaxis in HBDs could therefore affect marine nitrogen and carbon biogeochemistry by facilitating nitrogen fixation within otherwise oxic waters, while also altering particle degradation and the efficiency of the biological pump.
Nucleosome remodeling and deacetylation complex and MBD3 influence mouse embryonic stem cell naïve pluripotency under inhibition of protein kinase C
Authors: Dai Yujian , Sun Jialei , He Na , An Liyou , Hou Chunhui , Du Fuliang 
Published: August 2022

AbstractThe pluripotency of naïve mouse embryonic stem cells (mES) is regulated by multiple signaling pathways, with inhibition of protein kinase C (PKCi) playing a particularly important role in maintaining naïve mES. However, the regulatory function of nucleosome remodeling and deacetylase (NuRD) complex in mES cultured in a PKCi system is unknown. We found that, compared with 2iL-derived mES, PKCi-derived mES showed low mRNA expression of NuRD complex subunits, including MBD3, HDAC1/HDAC2, MTA1, and RbAP46/RbAP48. Western blot showed that PKCi-derived mES expressed lower protein levels of MBD3 and HDAC2 at passage 3, as well as MBD3, HDAC2, and MTA1 at passage 10, indicating that PKCi suppressed NuRD complex expression. Knockdown of MBD3 increased PKCi-derived mES pluripotency by increasing NANOG and OCT4 expression and colony formation. By contrast, overexpression of MBD3 or removal of PKC inhibitor-induced differentiation of mES, results in reduced NANOG, OCT4, and REX1 expression and colony formation, increased differentiation-related gene expression, and differentiation into flat cells. Knockdown of MBD3 in mES upon PKC inhibitor removal partially reversed cell differentiation. Our results show that the regulatory NuRD complex and its MBD3 subunit influence the naïve pluripotency of mES cultured in a PKCi system.
Coupled influence of tectonics, climate, and surface processes on landscape evolution in southwestern North America
Authors: Bahadori Alireza , Holt William E. , Feng Ran , Austermann Jacqueline , Loughney Katharine M. , Salles Tristan , Moresi Louis , Beucher Romain , Lu Neng , Flesch Lucy M. , Calvelage Christopher M. , Rasbury E. Troy , Davis Daniel M. , Potochnik Andre R. , Ward W. Bruce , Hatton Kevin , Haq Saad S. B. , Smiley Tara M. , Wooton Kathleen M. , Badgley Catherine 
Published: August 2022

AbstractThe Cenozoic landscape evolution in southwestern North America is ascribed to crustal isostasy, dynamic topography, or lithosphere tectonics, but their relative contributions remain controversial. Here we reconstruct landscape history since the late Eocene by investigating the interplay between mantle convection, lithosphere dynamics, climate, and surface processes using fully coupled four-dimensional numerical models. Our quantified depth-dependent strain rate and stress history within the lithosphere, under the influence of gravitational collapse and sub-lithospheric mantle flow, show that high gravitational potential energy of a mountain chain relative to a lower Colorado Plateau can explain extension directions and stress magnitudes in the belt of metamorphic core complexes during topographic collapse. Profound lithospheric weakening through heating and partial melting, following slab rollback, promoted this extensional collapse. Landscape evolution guided northeast drainage onto the Colorado Plateau during the late Eocene-late Oligocene, south-southwest drainage reversal during the late Oligocene-middle Miocene, and southwest drainage following the late Miocene.
Real-time 3D analysis during electron tomography using tomviz
Authors: Schwartz Jonathan , Harris Chris , Pietryga Jacob , Zheng Huihuo , Kumar Prashant , Visheratina Anastasiia , Kotov Nicholas A. , Major Brianna , Avery Patrick , Ercius Peter , Ayachit Utkarsh , Geveci Berk , Muller David A. , Genova Alessandro , Jiang Yi , Hanwell Marcus , Hovden Robert 
Published: August 2022

AbstractThe demand for high-throughput electron tomography is rapidly increasing in biological and material sciences. However, this 3D imaging technique is computationally bottlenecked by alignment and reconstruction which runs from hours to days. We demonstrate real-time tomography with dynamic 3D tomographic visualization to enable rapid interpretation of specimen structure immediately as data is collected on an electron microscope. Using geometrically complex chiral nanoparticles, we show volumetric interpretation can begin in less than 10 minutes and a high-quality tomogram is available within 30 minutes. Real-time tomography is integrated into tomviz, an open-source and cross-platform 3D data analysis tool that contains intuitive graphical user interfaces (GUI), to enable any scientist to characterize biological and material structure in 3D.
Frequency wavelength multiplexed optoacoustic tomography
Authors: Stylogiannis Antonios , Prade Ludwig , Glasl Sarah , Mustafa Qutaiba , Zakian Christian , Ntziachristos Vasilis 
Published: August 2022

AbstractOptoacoustics (OA) is overwhelmingly implemented in the Time Domain (TD) to achieve high signal-to-noise ratios by maximizing the excitation light energy transient. Implementations in the Frequency Domain (FD) have been proposed, but suffer from low signal-to-noise ratios and have not offered competitive advantages over time domain methods to reach high dissemination. It is therefore commonly believed that TD is the optimal way to perform optoacoustics. Here we introduce an optoacoustic concept based on pulse train illumination and frequency domain multiplexing and theoretically demonstrate the superior merits of the approach compared to the time domain. Then, using recent advances in laser diode illumination, we launch Frequency Wavelength Multiplexing Optoacoustic Tomography (FWMOT), at multiple wavelengths, and experimentally showcase how FWMOT optimizes the signal-to-noise ratios of spectral measurements over time-domain methods in phantoms and in vivo. We further find that FWMOT offers the fastest multi-spectral operation ever demonstrated in optoacoustics.
Highly conserved shifts in ubiquitin-proteasome system (UPS) activity drive mitochondrial remodeling during quiescence
Authors: Yue Sibiao , Wang Lei , DeMartino George N. , Zhao FangZhou , Liu Yi , Sieber Matthew H. 
Published: August 2022

AbstractDefects in cellular proteostasis and mitochondrial function drive many aspects of infertility, cancer, and other age-related diseases. All of these conditions rely on quiescent cells, such as oocytes and adult stem cells, that reduce their activity and remain dormant as part of their roles in tissue homeostasis, reproduction, and even cancer recurrence. Using a multi-organism approach, we show that dynamic shifts in the ubiquitin proteasome system drive mitochondrial remodeling during cellular quiescence. In contrast to the commonly held view that the ubiquitin-proteasome system (UPS) is primarily regulated by substrate ubiquitination, we find that increasing proteasome number and their recruitment to mitochondria support mitochondrial respiratory quiescence (MRQ). GSK3 triggers proteasome recruitment to the mitochondria by phosphorylating outer membrane proteins, such as VDAC, and suppressing mitochondrial fatty acid oxidation. This work defines a process that couples dynamic regulation of UPS activity to coordinated shifts in mitochondrial metabolism in fungi, Drosophila, and mammals during quiescence.
Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy
Authors: del Amo-Maestro Laura , Mendes Soraia R. , Rodríguez-Banqueri Arturo , Garzon-Flores Laura , Girbal Marina , Rodríguez-Lagunas María José , Guevara Tibisay , Franch Àngels , Pérez-Cano Francisco J. , Eckhard Ulrich , Gomis-Rüth F. Xavier 
Published: August 2022

AbstractThe digestion of gluten generates toxic peptides, among which a highly immunogenic proline-rich 33-mer from wheat α-gliadin, that trigger coeliac disease. Neprosin from the pitcher plant is a reported prolyl endopeptidase. Here, we produce recombinant neprosin and its mutants, and find that full-length neprosin is a zymogen, which is self-activated at gastric pH by the release of an all-β pro-domain via a pH-switch mechanism featuring a lysine plug. The catalytic domain is an atypical 7+8-stranded β-sandwich with an extended active-site cleft containing an unprecedented pair of catalytic glutamates. Neprosin efficiently degrades both gliadin and the 33-mer in vitro under gastric conditions and is reversibly inactivated at pH > 5. Moreover, co-administration of gliadin and the neprosin zymogen at the ratio 500:1 reduces the abundance of the 33-mer in the small intestine of mice by up to 90%. Neprosin therefore founds a family of eukaryotic glutamate endopeptidases that fulfils requisites for a therapeutic glutenase.
ROR2 regulates self-renewal and maintenance of hair follicle stem cells
Authors: Veltri Anthony , Lang Christopher M. R. , Cangiotti Gaia , Chan Chim Kei , Lien Wen-Hui 
Published: August 2022

AbstractHair follicles undergo cycles of regeneration fueled by hair follicle stem cells (HFSCs). While β-catenin-dependent canonical Wnt signaling has been extensively studied and implicated in HFSC activation and fate determination, very little is known about the function of β-catenin-independent Wnt signaling in HFSCs. In this study, we investigate the functional role of ROR2, a Wnt receptor, in HFSCs. By analyzing Ror2-depleted HFSCs, we uncover that ROR2 is not only essential to regulate Wnt-activated signaling that is responsible for HFSC activation and self-renewal, but it is also required to maintain proper ATM/ATR-dependent DNA damage response, which is indispensable for the long-term maintenance of HFSCs. In analyzing HFSCs lacking β-catenin, we identify a compensatory role of ROR2-PKC signaling in protecting β-catenin-null HFSCs from the loss of stem cell pool. Collectively, our study unveils a previously unrecognized role of ROR2 in regulation of stem cell self-renewal and maintenance.
Bacterial biofilm functionalization through Bap amyloid engineering
Authors: Matilla-Cuenca Leticia , Taglialegna Agustina , Gil Carmen , Toledo-Arana Alejandro , Lasa Iñigo , Valle Jaione 
Published: August 2022

AbstractBiofilm engineering has emerged as a controllable way to fabricate living structures with programmable functionalities. The amyloidogenic proteins comprising the biofilms can be engineered to create self-assembling extracellular functionalized surfaces. In this regard, facultative amyloids, which play a dual role in biofilm formation by acting as adhesins in their native conformation and as matrix scaffolds when they polymerize into amyloid-like fibrillar structures, are interesting candidates. Here, we report the use of the facultative amyloid-like Bap protein ofStaphylococcus aureusas a tool to decorate the extracellular biofilm matrix or the bacterial cell surface with a battery of functional domains or proteins. We demonstrate that the localization of the functional tags can be change by simply modulating the pH of the medium. Using Bap features, we build a tool for trapping and covalent immobilizing molecules at bacterial cell surface or at the biofilm matrix based on the SpyTag/SpyCatcher system. Finally, we show that the cell wall of several Gram-positive bacteria could be functionalized through the external addition of the recombinant engineered Bap-amyloid domain. Overall, this work shows a simple and modulable system for biofilm functionalization based on the facultative protein Bap.