bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biocontrol Potential of Bacillus velezensis wr8 secondary metabolites against Penicillium sp.
Authors: Wang Rui , Wang Xiaohu , Weng Yuting , Lan Baofeng , Zhou Liqin , Yang Hui 
Published: July 2022

Abstract

Blue mold caused by Penicillium sp. is one of the most serious postharvest diseases of citrus fruit. The aim of this study was to isolate and identify native Bacillus with inhibition phenotypes of citrus plants fruits. We investigated the antifungal effect of Bacillus velezensis wr8 on the postharvest pathogens Penicillium sp. inoculated on fruits, as well as on the growth of these fungi on Petri dishes with defined media. MALDI-TOF MS was conducted to illuminate the underlying mechanism. Results showed that Bacillus velezensis wr8 significantly inhibited Penicillium sp. growth in vitro. Moreover, secondary metabolites suppressed the disease development of citrus fruits artificially inoculated with Penicillium sp. in 25℃. Furthermore, MALDI-TOF MS indicated that lipoprotein with the molecular mass of 30.2 kDa was a key component about against Penicillium sp.. In addition, the secondary metabolites with antibacterial activity against Escherichia coli showed antimicrobial peptide with the molecular weight of 9.8 kDa. These results demonstrated that Bacillus velezensis wr8 could produce lipoprotein and antimicrobial peptide to inhibit Penicillium sp. and Escherichia coli which has broad application prospect in the future development. Finally, Bacillus velezensis wr8 is to provide data support for the development and utilization of high activity bacteriocin at room temperature and its application in the field of food safety.
The Effect of Building Orientation on Energy Efficiency
Authors: Habibi Shahryar 
Published: July 2022

Abstract
The energy demand of buildings is currently central to the generation of greenhouse gas emissions, primarily from the combustion of fossil fuels for energy. As energy demand increases, it is critical to reduce energy-related greenhouse gas emissions in the building sector. Several architectural studies have shown that building orientation is one of the first decisions that affect building performance. However, there are still many misaligned buildings where energy costs are higher than when standard methods are used. To address this discrepancy, a research study was conducted using different building profiles. Simulations were run as part of the research to link a building's orientation to performance measures such energy use intensity (EUI), cooling load, and heating load. In addition, the impacts of solar heat gain and ventilation air exchange values on building energy performance at various orientations were demonstrated. Although building orientation affects building energy performance, the study shows that not all building efficiency factors are equally affected by orientation, and the effects vary by climate zone and building size.
Metadichol® is a nano lipid emulsion that expresses all 48 nuclear receptors in stem and somatic cells
Authors: Raghavan Palayakotai R 
Published: July 2022

Abstract

Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes. There are many literature references to work on NR expression in many organs, abnormal cells, and tissues. However, a simple universal method to study the expression of NR is still missing. Here, we present systematic profiling of NRs in human umbilical cord stem cell lines and assess the expression of the 48 human NRs by quantitative real-time (qRT)-PCR using Metadichol, a nanoemulsion made of natural lipid alcohol. Metadichol-treated umbilical cord cells and fibroblasts, where all cells expressed NRs at a concentration range of 1 pg-100 ng/mL in a dependent manner, were detected by qRT-PCR and qualified by Western blotting. This method will allow the study of many organs and tissues and expand our understanding of the role of NRs and their role in mitigating diseases. HighlightsMetadichol treatment of somatic cells leads to nuclear receptor expressionDepending on the cell and concentration of Metadichol used, fold changes are differentThe method could be used to study many cells and disease cells to better understand NR expression patterns and implications.The results suggest that Metadichol is a universal ligand to all nuclear receptors.
ZoDIAC: Zoneout Dropout Injection Attention Calculation
Authors: Zohourianshahzadi Zanyar , Kalita Jugal 
Published: July 2022

Abstract
Recently the use of self-attention has yielded to state-of-the-art results in vision-language tasks such as image captioning as well as natural language understanding and generation (NLU and NLG) tasks and computer vision tasks such as image classification. This is since self-attention maps the internal interactions among the elements of input source and target sequences. Although self attention successfully calculates the attention values and maps the relationships among the elements of input source and target sequence, yet there is no mechanism to control the intensity of attention. In real world, when communicating with each other face to face or vocally, we tend to express different visual and linguistic context with various amounts of intensity. Some words might carry (be spoken with) more stress and weight indicating the importance of that word in the context of the whole sentence. Based on this intuition, we propose Zoneout Dropout Injection Attention Calculation (ZoDIAC) in which the intensities of attention values in the elements of the input sequence are calculated with respect to the context of the elements of input sequence. The results of our experiments reveal that employing ZoDIAC leads to better performance in comparison with the self-attention module in the Transformer model. The ultimate goal is to find out if we could modify self-attention module in the Transformer model with a method that is potentially extensible to other models that leverage on self-attention at their core. Our findings suggest that this particular goal deserves further attention and investigation by the research community. The code for ZoDIAC is available on www.github.com/zanyarz/zodiac.
Smokeless Tobacco Enhance Allergic Inﬂammation, Exacerbation of Asthma and Oxidative Stress in Asthmatic Patients from Algeria
Authors: Khaldi Taha , Boughemara Karima , Hesnie Yasmine Khodja , Amira Aicha Beya , Messarah Mahfoud , Boumendjel Amel 
Published: July 2022

Abstract
Background and objective
Despite their effects on human health, the link between smokeless tobacco (ST) consumption and asthma severity in asthmatic patients is still unknown. Thus, the present study aims to complete the lack of information by investigating the aggravation of inflammation, exacerbation of asthma, oxidative stress and cytotoxicity induced by ST in asthmatic patients.
Methods
The study recruited 80 male volunteers residing in Annaba town, Algeria, divided into four groups by using a questionnaire, each group consists of 20 male volunteers. Herein, biochemical parameters, hematological parameters, C-reactive protein (CRP), total IgE, interleukin-5 (IL-5), nitric oxide (NO) and oxidative stress were measured.
Results
The obtained results showed that ST clearly enhanced lung inflammation and exacerbation of asthma through total IgE, IL-5 and CRP increased production. In addition, ST was found to intensify oxidative stress via increased lipid peroxidation and decreased reduced glutathione (GSH) levels. Likewise, the biochemical and hematological parameters results showed that ST causes damage and inflammation to tissues.
Conclusion
Therefore, our study reveals that ST obviously enhances allergic inflammation in patients suffering from asthma.
Clinical study to verify the effectiveness and safety of the modified isothymol or carvacrol compound against SARS-CoV-2 in COVID-19 patients
Authors: OJEDA RAUL A 
Published: July 2022

Abstract
BACKGROUND
Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), none have yet been shown to be efficacious.
METHODS
A double-blind, randomised, placebo-controlled trial of isothymol was conducted in adults hospitalised for COVID-19 with evidence of lower respiratory tract involvement. Patients were randomised to receive modified isotimol (6mg/ml) or placebo for up to 15 days. The primary outcome was recovery time, defined by hospital discharge or hospitalisation for infection control purposes only.
RESULTS
A double-blind, randomised, placebo- and isothymol-modified, placebo-controlled trial was conducted in adults who were hospitalised with COVID-19. Patients were randomised to receive isothymol (6 mg/ml) or placebo for up to 15 days. The primary outcome was recovery time, defined by hospital discharge. Results from the 600 patients (300 treated with isothymol and 300 with placebo) with data available after randomisation suggest that those receiving isothymol had a median recovery time of 7 days (95% confidence interval (CI), 5 to 9), compared with 14 days (95% CI, 11 to 15) in those receiving placebo (recovery rate ratio, 1.24; 95% CI, 0.78 to 1.87; P < 0.001). Kaplan-Meier estimates of 15-day mortality were 0% with Isotimol and 4% with placebo. No serious adverse events were reported in patients in the isothymol group who underwent randomisation and 13 of the 300 patients in the placebo group who underwent randomisation (4.33%). Analysis in blood plasma from patients revealed a close relationship between hypersensitivity of inflammatory mediators (macrophages and type I interferons) and elevated histamine production, resulting from autophosphorylation and increased production of interleukin-6 (IL-6) in blood monocytes from patients with severe COVID-19 compared to blood monocytes from healthy volunteers.
CONCLUSIONS
Isothymol was superior to placebo in shortening recovery time in hospitalised adults with COVID-19 and evidence of lower respiratory tract infection.
TRIAL REGISTRATION
This study was approved by the Ethics Committee in Research with Human Beings of the institution of origin (protocol LAB-2020-01) and registered in the ISRCTN Registry, number: ISRCTN15363958.
Reflections on the Methodological Development and Utility of the Kidscreen-52 Quality of Life Questionnaire: A Transdisciplinary Methodologization
Authors: Kachnic Filip 
Published: July 2022

Abstract
The purpose of this study is to critically explore the methodology for item generation used in the development of the Kidscreen-52 quality of life questionnaire. The reason for conducting this study is the long-standing need for methodological insights both in cross-cultural health-related survey research and educational research on immigrant children. We were led by the following research questions: (1) What methodological principles do emerge in evidence-based educational research on immigrant children?, and (2) In which ways are these methodological principles present in the methodology of Kidscreen-52? To answer the first question we conducted a rapid review. The final interconnection analysis revealed three overarching elements: (1) Kidscreen focus groups enabled peer interactions by involving relational authenticity, a concept found in educational research (Noddings, 2015), (2) due to their inherent group dynamics the Kidscreen focus groups increased participants'verbal and non-verbal expressions, and (3) by covering a greater range of experiences the Kidscreen focus groups have enhanced reflexivity that is instrumental for capturing cross-cultural experiences of vulnerable children populations.
Relação das habilidades auditivas e linguísticas com a aprendizagem:
Authors: Hanna Hanna Padilha Lordão , Fernandes Teixeira Cleide , Cavalcante Manoelina Xavier , Melo Jéssica Katarina Olímpia de , Queiroga Bianca Arruda Manchester de 
Published: July 2022

O objetivo do estudo foi investigar o conhecimento de professores da Rede Municipal de Ensino do Recife sobre a relação das habilidades auditivas e linguísticas com a aprendizagem, sobre a fonoaudiologia educacional e o perfil de formação dos professores dos primeiros anos da escolarização básica do Brasil. Trata-se de um estudo exploratório quantitativo e qualitativo, realizado com 488 professores que lecionam na rede pública de ensino do município de Recife/PE/Brasil. Os dados foram recolhidos por meio de um questionário estruturado, aplicado durante encontros mensais de formação continuada para professores. Os resultados revelaram que os professores reconhecem, de um modo geral, a importância da audição e da linguagem para a aprendizagem, embora não se sintam preparados para lidar com isso na escola e, como esperado, não possuem conhecimentos mais específicos sobre o processamento auditivo. Consequentemente, os encaminhamentos para especialistas da saúde são frequentes diante dos problemas de aprendizagem, desconsiderando as habilidades auditivas. Conclui-se que os professores reconhecem a importância do tema abordado; contudo, demonstram não ter domínio sobre a relevância das habilidades auditivas e linguísticas para a aprendizagem e para o desenvolvimento do estudante, bem como conhecimentos sobre o papel do fonoaudiólogo no âmbito escolar.
“Eu não gosto dessa história de mentiras!”
Authors: Moraes Jéssica Tairâne de , Felipe Jane 
Published: July 2022

O presente artigo discute alguns aspectos teórico-metodológicos e éticos envolvidos na construção de uma pesquisa realizada com crianças de cinco anos de idade, alunas da rede municipal de Educação Infantil, em uma cidade da Região Metropolitana de Porto Alegre, situada no estado do Rio Grande do Sul / Brasil. O objetivo central da investigação foi compreender como as crianças percebiam e interpretavam as violências de gênero vividas no âmbito familiar e/ou no seu entorno. A partir das teorizações propostas pela Sociologia da Infância e pelos Estudos de Gênero, foram utilizadas estratégias para promover esse debate com as crianças por meio de rodas de conversa e da leitura literária. Os resultados da pesquisa apontaram para a importância da participação das crianças no desenvolvimento da investigação e dentro de princípios éticos, envolvendo o respeito às suas visões de mundo e possibilitando o reconhecimento e a identificação de situações de violência e de seus possíveis desdobramentos.
Analisis Perkembangan Self-help Skills Anak Usia 5-6 Tahun
Authors: Umuri Sania Alkhoiriyah , Rahmawati Anayanti , Sholeha Vera 
Published: July 2022

Self-help skills adalah keterampilan motorik yang dapat membantu anak untuk memenuhi kebutuhan dasar secara mandiri. Perkembangan self-help skills merupakan proses ketika anak memperoleh self-help skills selama masa transisi dari bayi ke awal masa kanak-kanak. Penelitian ini bertujuan mengetahui perkembangan self-help skills anak usia 5-6 tahun di Gugus Irawati Kabupaten Sukoharjo. Penelitian ini menggunakan pendekatan kuantitatif survei. Teknik sampling yang digunakan adalah total sampling. Populasi dan sampel penelitian adalah anak usia 5-6 tahun berjumlah 81 anak. Teknik pengumpulan data yang digunakan adalah kuesioner, wawancara dengan orang tua dan guru serta observasi di salah satu TK. Teknik uji validitas menggunakan pendapat ahli (expert judgement) untuk menilai kesesuaian antara instrumen dengan aspek yang diukur. Teknik analisis data yang digunakan adalah analisis data deskriptif persentase dimaksudkan untuk mendeskripsikan status variabel kemudian menyajikannya dalam bentuk persentase. Hasil penelitian menunjukkan bahwa secara umum perkembangan self-help skills anak usia 5-6 tahun di Gugus Irawati Kabupaten Sukoharjo termasuk pada kriteria BSB (Berkembang Sangat Baik) namun terdapat perbedaan skor antara data kuesioner orang tua dan guru. Persentase data orang tua 80,26% dan data guru 81,35%.
Evaluation of Medical Information on Male Sexual Dysfunction on Baidu Encyclopedia and Wikipedia: Comparative Study
Authors: Ma Ming , Yin Saifu , Zhu Mengli , Fan Yu , Wen Xi , Lin Tao , Song Turun 
Published: July 2022

Background
Sexual dysfunction is a private set of disorders that may cause stigma for patients when discussing their private problems with doctors. They might also feel reluctant to initiate a face-to-face consultation. Internet searches are gradually becoming the first choice for people with sexual dysfunction to obtain health information. Globally, Wikipedia is the most popular and consulted validated encyclopedia website in the English-speaking world. Baidu Encyclopedia is becoming the dominant source in Chinese-speaking regions; however, the objectivity and readability of the content are yet to be evaluated.

Objective
Hence, we aimed to evaluate the reliability, readability, and objectivity of male sexual dysfunction content on Wikipedia and Baidu Encyclopedia.

Methods
The Chinese Baidu Encyclopedia and English Wikipedia were investigated. All possible synonymous and derivative keywords for the most common male sexual dysfunction, erectile dysfunction, premature ejaculation, and their most common complication, chronic prostatitis/chronic pelvic pain syndrome, were screened. Two doctors evaluated the articles on Chinese Baidu Encyclopedia and English Wikipedia. The Journal of the American Medical Association (JAMA) scoring system, DISCERN instrument, and Global Quality Score (GQS) were used to assess the quality of disease-related articles.

Results
The total DISCERN scores (P=.002) and JAMA scores (P=.001) for Wikipedia were significantly higher than those of Baidu Encyclopedia; there was no statistical difference between the GQS scores (P=.31) for these websites. Specifically, the DISCERN Section 1 score (P<.001) for Wikipedia was significantly higher than that of Baidu Encyclopedia, while the differences between the DISCERN Section 2 and 3 scores (P=.14 and P=.17, respectively) were minor. Furthermore, Wikipedia had a higher proportion of high total DISCERN scores (P<.001) and DISCERN Section 1 scores (P<.001) than Baidu Encyclopedia. Baidu Encyclopedia and Wikipedia both had low DISCERN Section 2 and 3 scores (P=.49 and P=.99, respectively), and most of these scores were low quality.

Conclusions
Wikipedia provides more reliable, higher quality, and more objective information than Baidu Encyclopedia. Yet, there are opportunities for both platforms to vastly improve their content quality. Moreover, both sites had similar poor quality content on treatment options. Joint efforts of physicians, physician associations, medical institutions, and internet platforms are needed to provide reliable, readable, and objective knowledge about diseases.
THERE IS NO POSSIBILITY OF ANOTHER SUBJECT ON THE PERSONA “WE” FROM REAGAN’S POEM LIFE
Authors: Iswalono Astrinda Nilasastri 
Published: July 2022

Written by young Reagan, Life is a poem with a distinctive discourse as a literary work in the beginning of American modernism. The study of Life in the present article focuses on the interpretation of “we” and is contextualized within the historical narratives of the Puritans and the spirit of American Dream in the 20s. The analysis of the poem’s representations of the symbolic, the imaginary, and the Truth presented here is a Žižekian reading of the subjects “we” in the poem’s text who appear to get themselves into a pseudo activity in relation to the narratives of the Founding Fathers as the chosen ones in the holy journey of establishing America. The speaker of the poem, which is part of “we,” reflects the spirit of American Dream and reminds his fellow Americans to keep going amidst the feeling of alienation caused by the modern capitalism that is expressed by words “suffer”, “struggle”, “weep”, “drench”, “break”, “jade”, “sorrow”, “warp” and “pain” 15 times in only 8 stanzas/32 lines. The speaker’s sense of Americanism becomes the only Truth for the “we” until they grow their own Cynical Awareness.
Kebijakan Hukum Pidana atas Tindak Pidana Penghinaan terhadap Presiden dan Wakil Presiden
Authors: Parsada Laksamana Rihdo , Sudarti Elly , Arfa Nys 
Published: July 2022

This article aims to find out how to follow up on criminal law for criminal acts of insulting the President and vice president and to find out how in the future criminal law policies are related to insults to the President and Vice President. The problem in this paper is how to regulate the criminal act of insulting the President and Vice President? And what about future criminal law policies related to the regulation of insulting the President and Vice President? The research method used in this research is normative legal research. The results of this study state that insults to the President and Vice President need a law that specifically regulates because considering the President is a symbol of sovereignty and the previous law has been revoked through the Constitutional Court's decision Number: 013-022/PUUIV/2006 and the Constitutional Court's decision Number: 6/PUU -V/2007 and the use of UU ITE is less precise because UU only regulates in general terms. Therefore, it is necessary to reform the law to emphasize cases of insult to the President and be able to provide special legal protection to the President and Vice President in the future so that things like this do not happen again.

ABSTRAK
Artikel ini bertujuan untuk mengetahui bagaimana tindak lanjut dari hukum pidana untuk tindak pidana penghinaan terhadap Presiden dan wakil presiden serta untuk mengetahui bagaimana kedepannya kebijakan hukum pidana terkait dengan penghinaan terhadap Presiden dan Wakil Presiden. Dalam tulisan ini membahas bagaimana pengaturan tindak pidana penghinaan terhadap Presiden dan Wakil Presiden. Bagaimana kebijakan hukum pidana kedepannya terkait dengan pengaturan penghinaan Presiden dan Wakilnya. Penelitian ini adalah tipe penelitian hukum normatif. Penelitian ini menyatakan bahwa penghinaan terhadap Presiden dan Wakil Presiden diperlukan hukum yang mengatur secara tepat mengingat Presiden merupakan simbol kedaulatan dan hukum yang ada sebelumnya sudah dicabut melalui putusan Mahkama konstitusi Nomor: 013-022/PUUIV/2006 dan putusan Mahkama konstitusi Nomor: 6/PUU-V/2007 serta kurang tepatnya menggunakan UU ITE karena UU tersebut hanya mengatur secara umum. Maka dari itu saran yang diajukan yaitu diperlukannya pembaharuan hukum agar dimasa yang akan datang dapat diberikan dengan hukuman yang lebih memberi sanksi tegas terhadap kasusu tersebut dan supaya hal seperti ini tidak terulang kembali dan mempunyai kekuatan hukum yang kuat dan pasti.
Prevalensi Retinopati Diabetik di Puskesmas di Bandung Raya Periode Januari 2019-Desember 2020
Authors: Shaniaputri Tiara , Iskandar Erwin , Fajriansyah Angga 
Published: July 2022

Peningkatan prevalensi penyandang Diabetes melitus (DM) dari tahun ke tahun berdampak terhadap peningkatan prevalensi retinopati diabetik. Penelitian ini bertujuan untuk mengetahui prevalensi retinopatidiabetik yang diharapkan dapat memberikan kontribusi dalam pencegahan dan penatalaksanaan retinopatidiabetik yang lebih baik. Penelitian ini merupakan penelitian deskriptif dengan metode penelitian potong lintangyang menggunakan data sekunder yaitu data dari 1.835 pasien DM yang mengikuti skrining retinopati diabetikdi puskesmas di Bandung Raya periode Januari 2019-Desember 2020. Variabel yang dinilai pada penelitian iniadalah prevalensi retinopati diabetik dan vision threatening diabetic retinopathy (VTDR) , usia, jenis kelamin,durasi DM Gula Darah Sewaktu (GDS), Gula Darah Puasa (GDP), Tekanan Darah Sistolik (TDS), TekananDarah Diastolik (TDD). Penelitian ini menunjukkan prevalensi retinopati diabetik dan VTDR sebesar 19,46%dan 7,68% secara berurutan. Prevalensi lebih tinggi pada perempuan. Pasien dengan durasi DM 10 tahunserta kadar GDS dan GDP 200 mg/dl memiliki prevalensi tertinggi. Berdasarkan pemeriksaan tekanan darah,prevalensi tertinggi terdapat pada pasien dengan nilai TDS 140 mmHg dan TDD < 90 mmHg. Pada penelitianini didapatkan bahwa kurang lebih 1 dari 4 pasien diabetes pada populasi ini menderita retinopati diabetik.