bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surfing in the phase space of spin--orbit coupling in binary asteroid systems
Authors: Jafari-Nadoushan Mahdi 
Published: December 2022

ABSTRACTFor a satellite with an irregular shape, which is the common shape among asteroids, the well-known spin--orbit resonance problem could be changed to a spin--orbit coupling problem since a decoupled model does not accurately capture the dynamics of the system. In this paper, having provided a definition for close binary asteroid systems, we explore the structure of the phase space in a classical Hamiltonian model for spin--orbit coupling in a binary system. To map out the geography of resonances analytically and the cartography of resonances numerically, we reformulate a fourth-order gravitational potential function, in Poincare variables, via Stokes coefficients. For a binary system with a near-circular orbit, isolating the Hamiltonian near each resonance yields the pendulum model. Analysis of the results shows the geographical information, including the location and width of resonances, is modified due to the prominent role of the semimajor axis in the spin--orbit coupling model but not structurally altered. However, this resulted in modified Chirikov criterion to predict onset of large-scale chaos. For a binary system with arbitrary closed orbit, we thoroughly surf in the phase space via cartography of resonances created by fast Lyapunov indicator maps. The numerical study confirms the analytical results, provides insight into the spin--orbit coupling, and shows some bifurcations in the secondary resonances which can occur due to material transfer. Also, we take the (65803) Didymos binary asteroid as a case to show analytical and numerical results.
The physical origin of galactic conformity: from theory to observation
Authors: Ayromlou Mohammadreza , Kauffmann Guinevere , Anand Abhijeet , White Simon D M 
Published: December 2022

ABSTRACT
We employ several galaxy formation models, particularly, L-GALAXIES, IllustrisTNG, and EAGLE, as well as observational samples from SDSS and dark energy spectroscopic intstrument (DESI), to investigate galactic conformity, the observed correlation between the star-formation properties of central (primary) galaxies and those of their neighbours. To analyse the models and observations uniformly, we introduce CenSat, a new algorithm to define whether a galaxy is a central or a satellite system. We find that the conformity signal is present, up to at least 5 Mpc from the centres of low- and intermediate-mass centrals in the latest version of L-GALAXIES (Ayromlou et al. 2021b), IllustrisTNG, and EAGLE, as well as in SDSS and DESI observational samples. In comparison, the conformity signal is substantially weaker in an older version of L-GALAXIES (Henriques et al. 2020). One of the main differences between this older model and the other models is that except for satellites within the boundaries of massive cluster haloes, it neglects ram-pressure stripping of the gas reservoirs of galaxies (e.g. in groups and cluster outskirts). Our observational comparisons demonstrate that this difference significantly affects the observed large-scale conformity signal. Furthermore, by examining the contribution of backsplash, fly-by, central, and satellite galaxies to the conformity signal, we show that much, but not all, of it arises from primary galaxies near massive systems. Remaining tensions between the models and observations may be solved by modifying the physical prescriptions for how feedback processes affect the distribution and kinematics of gas and the environment around galaxies out to scales of several Megaparsecs.
Discovery of TOI-1260d and the characterization of the multiplanet system
Authors: Lam K W F , Cabrera J , Hooton M J , Alibert Y , Bonfanti A , Beck M , Deline A , Florén H-G , Simon A E , Fossati L , Persson C M , Fridlund M , Salmon S , Hoyer S , Osborn H P , Wilson T G , Georgieva I Y , Nowak Gr , Luque R , Egger J A , Adibekyan V , Alonso R , Escudé G A , Bárczy T , Barrado D , Barros S C C , Baumjohann W , Beck T , Bekkelien A , Benz W , Billot N , Bonfils X , Brandeker A , Broeg C , Charnoz S , Cameron A C , Csizmadia Sz , Davies M B , Deleuil M , Delrez L , Demangeon O D S , Demory B-O , Ehrenreich D , Erikson A , Fortier A , Futyan D , Gandolfi D , Gillon M , Guedel M , Guterman P , Laskar J , Latham D W , Lecavelier des Etangs A , Lendl M , Lovis C , Heng K , Isaak K G , Kiss L , Magrin D , Maxted P F L , Nascimbeni V , Olofsson G , Ottensamer R , Pagano I , Pallé E , Peter G , Piotto G , Pollacco D , Queloz D , Ribas I , Ragazzoni R , Rando N , Rauer H , Santos N C , Scandariato G , Seager S , Ségransan D , Serrano L M , Smith A M S , Sousa S G , Steller M , Szabó Gy M , Thomas N , Udry S , Van Grootel V , Walton N A , Winn. J N 
Published: December 2022

ABSTRACT
We report the discovery of a third planet transiting the star TOI-1260, previously known to host two transiting sub-Neptune planets with orbital periods of 3.127 and 7.493 d, respectively. The nature of the third transiting planet with a 16.6-d orbit is supported by ground-based follow-up observations, including time-series photometry, high-angular resolution images, spectroscopy, and archival imagery. Precise photometric monitoring with CHEOPS allows to improve the constraints on the parameters of the system, improving our knowledge on their composition. The improved radii of TOI-1260b and TOI-1260c are $2.36 \pm 0.06 \rm R_{\oplus }$, $2.82 \pm 0.08 \rm R_{\oplus }$, respectively while the newly discovered third planet has a radius of $3.09 \pm 0.09 \rm R_{\oplus }$. The radius uncertainties are in the range of 3 per cent, allowing a precise interpretation of the interior structure of the three planets. Our planet interior composition model suggests that all three planets in the TOI-1260 system contains some fraction of gas. The innermost planet TOI-1260b has most likely lost all of its primordial hydrogen-dominated envelope. Planets c and d were also likely to have experienced significant loss of atmospheric through escape, but to a lesser extent compared to planet b.
Testing horndeski gravity with S2 star orbit
Authors: Della Monica R , de Martino I , Vernieri D , de Laurentis M 
Published: December 2022

ABSTRACT
We have explored a completely new and alternative way to restrict the parameter space of Horndeski theory of gravity. Using its Newtonian limit, it is possible to test the theory at a regime where, given its complexity and the small magnitude of the expected effects, it is poorly probed. At Newtonian level, it gives rise to a generalized Yukawa-like Newtonian potential which we have tested using S2 star orbit data. Our model adds five parameters to the General Relativity model, and the analysis constrains two of them with unprecedented precision to these energy scales, while it only gives an exclusion region for the remaining parameters. We have shown the potential of weak-field tests to constrain Horndeski gravity opening, as a matter of fact, which is a new avenue that deserves to be further, and deeply, explored in the near future.
Colour and infall time distributions of satellite galaxies in simulated Milky-Way analogues
Authors: Pan Yue , Simpson Christine M , Kravtsov Andrey , Gómez Facundo A , Grand Robert J J , Marinacci Federico , Pakmor Rüdiger , Manwadkar Viraj , Esmerian Clarke J 
Published: December 2022

ABSTRACT
We use the Auriga simulations to probe different satellite quenching mechanisms operating at different mass scales ($10^5 \, \mathrm{M}_\odot \lesssim M_\star \lesssim 10^{11} \, \mathrm{M}_\odot$) in Milky Way-like hosts. Our goal is to understand the origin of the satellite colour distribution and star-forming properties in both observations and simulations. We find that the satellite populations in the Auriga simulations, which was originally designed to model Milky Way-like host galaxies, resemble the populations in the Exploration of Local VolumE Satellites (ELVES) Survey and the Satellites Around Galactic Analogs (SAGA) survey in their luminosity function in the luminosity range −12 ≲ MV ≲ −15 and resemble ELVES in their quenched fraction and colour–magnitude distribution in the luminosity range −12 ≲ Mg ≲ −15. We find that satellites transition from blue colours to red colours at the luminosity range −15 ≲ Mg ≲ −12 in both the simulations and observations and we show that this shift is driven by environmental effects in the simulations. We demonstrate also that the colour distribution in both simulations and observations can be decomposed into two statistically distinct populations based on their morphological type or star-forming status that are statistically distinct. In the simulations, these two populations also have statistically distinct infall time distributions. The comparison presented here seems to indicate that this tension is resolved by the improved target selection of ELVES, but there are still tensions in understanding the colours of faint galaxies, of which ELVES appears to have a significant population of faint blue satellites not recovered in Auriga.
Unveiling the hosts of parsec-scale massive black hole binaries: morphology and electromagnetic signatures
Authors: Izquierdo-Villalba David , Sesana Alberto , Colpi Monica 
Published: December 2022

ABSTRACT
Parsec-scale massive black hole binaries (MBHBs) are expected to form in hierarchical models of structure formation. Even though different observational strategies have been designed to detect these systems, a theoretical study is a further guide for their search and identification. In this work, we investigate the hosts properties and the electromagnetic signatures of massive black holes gravitationally bound on parsec-scales with primary mass $\rm {\gt }\, 10^7\, M_{\odot }$. For that, we construct a full-sky light-cone by the use of the semi-analytical model L-Galaxies  in which physically motivated prescriptions for the formation and evolution of MBHBs have been included. Our predictions show that the large majority of the MBHBs are placed either in spiral galaxies with a classical bulge structure or in elliptical galaxies. Besides, the scaling relations followed by MBHBs are indistinguishable from the ones of single massive black holes. We find that the occupation fraction of parsec-scale MBHBs reaches up to ${\sim }\, 50{{\ \rm per\ cent}}$ in galaxies with $\rm M_{stellar}\, {\gt }\, 10^{11}\, M_{\odot }$ and drops below 10 per cent for $\rm M_{stellar}\, {\lt }\, 10^{11}\, M_{\odot }$. Our model anticipates that the majority of parsec-scale MBHBs are unequal mass systems and lie at $z\, {\sim }\, 0.5$, with ${\sim }\, 20$ objects per $\rm deg^2$ in the sky. However, most of these systems are inactive, and only $\rm {1-0.1}$ objects per $\rm deg^2$ have an electromagnetic counterpart with a bolometric luminosity in excess of 1043 erg s−1. Very luminous phases of parsec-scale MBHBs are more common at $z\, {\gt }\, 1$, but the number of binaries per $\rm deg^2$ is ${\lesssim }\, 0.01$ at $\rm L_{\rm bol}\, {\gt }\, 10^{45}\,\rm erg\,s^{-1}$.
Cerebrospinal fluid metabolic markers predict prognosis behavior of primary central nervous system lymphoma with high-dose methotrexate-based chemotherapeutic treatment
Authors: Zhou Liying , Li Qing , Xu Jingshen , Wang Shuaikang , Song Zhiqiang , Chen Xinyi , Ma Yan , Lin Zhiguang , Chen Bobin , Huang He 
Published: December 2022

AbstractBackgroundPrimary central nervous system lymphoma (PCNSL) is a highly aggressive non-Hodgkin’s B-cell lymphoma which normally treated by high-dose methotrexate (HD-MTX)-based chemotherapy. However, such treatment cannot always guarantee a good prognosis (GP) outcome while suffering several side effects. Thus, biomarkers or biomarker-based models that can predict PCNSL patient prognosis would be beneficial.MethodsWe first collected 48 patients with PCNSL and applied HPLC-MS/MS-based metabolomic analysis on such retrospective PCNSL patient samples. We then selected the highly dysregulated metabolites to build a logical regression model that can distinguish the survival time length by a scoring standard. Finally, we validated the logical regression model on a 33-patient prospective PCNSL cohort.ResultsSix metabolic features were selected from the cerebrospinal fluid (CSF) that can form a logical regression model to distinguish the patients with relatively GP (Z score ≤0.06) from the discovery cohort. We applied the metabolic marker-based model to a prospective recruited PCNSL patient cohort for further validation, and the model preformed nicely on such a validation cohort (AUC = 0.745).ConclusionsWe developed a logical regression model based on metabolic markers in CSF that can effectively predict PCNSL patient prognosis before the HD-MTX-based chemotherapy treatments.
Predictors of Nonadherence Among Patients With Infectious Complications of Substance Use Who Are Discharged on Parenteral Antimicrobial Therapy
Authors: Narayanan Shivakumar , Ching Patrick R , Traver Edward C , George Nivya , Amoroso Anthony , Kottilil Shyam 
Published: December 2022

Abstract

Background
The management of invasive infections related to substance use disorder (SUD) needing parenteral antimicrobial therapy is challenging and may have poor treatment outcomes including nonadherence and lack of completion of parenteral antimicrobial therapy.

Methods
In this retrospective cohort of 201 patients with invasive infections related to SUD, we looked at frequency and determinants of unfavorable outcomes including nonadherence.

Results
Seventy-nine percent of patients with SUD-related infection completed parenteral antibiotic therapy in skilled nursing facilities. A total of 21.5% of patient episodes had documentation of nonadherence. Nonadherence was higher in patients with active injection drug use (IDU) (28.5% versus 15% in non IDU; adjusted odds ratio [OR] 2.36; 95% confidence interval [CI], 1.1–5.5; P = .024), patients with active SUD in the prior year (24.5% vs 11%, P = .047), patients with use of more than 1 illicit substance (30.3% vs 17%, P = .031), as well as in people experiencing homelessness (32.8% vs 15.7% in stably housed, P = .005). In a multivariate model, nonadherence was significantly associated with IDU (OR, 2.38; 95% CI, 1.03–5.5) and homelessness (OR, 2.25; 95% CI, 1.01–4.8) Medication for opioid use disorder was prescribed at discharge in 68% of overall cohort and was not associated with improved outcomes for any of the above groups.

Conclusions
Nonadherence to parenteral antimicrobial therapy is high in the most vulnerable patients with unstable high-risk SUD and adverse social determinants of health.
HY5 inhibits lateral root initiation in Arabidopsis through negative regulation of the microtubule-stabilizing protein TPXL5
Authors: Qian Yanmin , Wang Xiaohong , Liu Yimin , Wang Xiangfeng , Mao Tonglin 
Published: December 2022

Abstract
Tight control of lateral root (LR) initiation is vital for root system architecture and function. Regulation of cortical microtubule reorganization is involved in the asymmetric radial expansion of founder cells during LR initiation in Arabidopsis (Arabidopsis thaliana). However, critical genetic evidence on the role of microtubules in LR initiation is lacking and the mechanisms underlying this regulation are poorly understood. Here, we found that the previously uncharacterized microtubule-stabilizing protein TPX2-LIKE5 (TPXL5) participates in LR initiation, which is finely regulated by the transcription factor ELONGATED HYPOCOTYL5 (HY5). In tpxl5 mutants, LR density was decreased and more LR primordia (LRPs) remained in stage I, indicating delayed LR initiation. In particular, the cell width in the peripheral domain of LR founder cells after the first asymmetric cell division was larger in tpxl5 mutants than in the wild-type. Consistently, ordered transverse cortical microtubule arrays were not well generated in tpxl5 mutants. In addition, HY5 directly targeted the promoter of TPXL5 and downregulated TPXL5 expression. The hy5 mutant exhibited higher LR density and fewer stage I LRPs, indicating accelerated LR initiation. Such phenotypes were partially suppressed by TPXL5 knockout. Taken together, our data provide genetic evidence supporting the notion that cortical microtubules are essential for LR initiation and unravel a molecular mechanism underlying HY5 regulation of TPXL5-mediated microtubule reorganization and cell remodeling during LR initiation.
Impaired Neuromuscular Efficiency and Symptom-Limited Aerobic Exercise Capacity 4 Weeks After Recovery From COVID-19 Appear to Be Associated With Disease Severity at Onset
Authors: Frazão Murillo , da Cruz Santos Amilton , Silva Paulo Eugênio , de Assis Pereira Cacau Lucas , Petrucci Tullio Rocha , Assis Mariela Cometki , de Almeida Leal Rômulo , Brasileiro Emanuella , de Moraes Forjaz Cláudia Lúcia , do Socorro Brasileiro-Santos Maria 
Published: December 2022

Abstract

Objective
The objectives of this study were to evaluate neuromuscular recruitment and efficiency in participants who recovered from COVID-19 and assess the association between neuromuscular efficiency and symptom-limited aerobic exercise capacity.

Methods
Participants who recovered from mild (n = 31) and severe (n = 17) COVID-19 were evaluated and compared with a reference group (n = 15). Participants underwent symptom-limited ergometer exercise testing with simultaneous electromyography evaluation after a 4-week recovery period. Activation of muscle fiber types IIa and IIb and neuromuscular efficiency (watts/percentage of root-mean-square obtained at the maximum effort) were determined from electromyography of the right vastus lateralis.

Results
Participants who had recovered from severe COVID-19 had lower power output and higher neuromuscular activity than the reference group and those who had recovered from mild COVID-19. Type IIa and IIb fibers were activated at a lower power output in participants who had recovered from severe COVID-19 than in the reference group and those who had recovered from mild COVID-19, with large effect sizes (0.40 for type IIa and 0.48 for type IIb). Neuromuscular efficiency was lower in participants who had recovered from severe COVID-19 than in the reference group and those who had recovered from mild COVID-19, with a large effect size (0.45). Neuromuscular efficiency showed a correlation with symptom-limited aerobic exercise capacity (r = 0.83). No differences were observed between participants who had recovered from mild COVID-19 and the reference group for any variables.

Conclusion
This physiological observational study supports the notion that more severe COVID-19 symptoms at disease onset appear to correspondingly impair neuromuscular efficiency in survivors over a short time frame of 4 weeks after recovery, potentially contributing to reduced cardiorespiratory capacity. Further studies are needed to replicate and extend these findings with respect to their clinical implications for assessment/evaluation and interventions.

Impact
After 4 weeks of recovery, neuromuscular impairment is particularly evident in severe cases; this problem may contribute to reduced cardiopulmonary exercise capacity.
Tuning macrophages for atherosclerosis treatment
Authors: Fang Fei , Xiao Crystal , Li Chunli , Liu Xiaoheng , Li Song 
Published: December 2022

Abstract
Atherosclerosis is a chronic inflammatory vascular disease and a leading cause of death worldwide. Macrophages play an important role in inflammatory responses, cell–cell communications, plaque growth and plaque rupture in atherosclerotic lesions. Here, we review the sources, functions and complex phenotypes of macrophages in the progression of atherosclerosis, and discuss the recent approaches in modulating macrophage phenotype and autophagy for atherosclerosis treatment. We then focus on the drug delivery strategies that target macrophages or use macrophage membrane-coated particles to deliver therapeutics to the lesion sites. These biomaterial-based approaches that target, modulate or engineer macrophages have broad applications for disease therapies and tissue regeneration.
Improved anti-Candida activity of hydrogel containing tea tree oil-loaded solid lipid nanoparticles for the treatment of oropharyngeal candidiasis
Authors: Mockdeci Hanny Reis , Junqueira Laura Andrade , Duarte Lucas Mattos , de Souza Moreira Carolina Paula , de Oliveira Marcone Augusto Leal , Brandão Marcos Antônio Fernandes , Tavares Guilherme Diniz , Raposo Nádia Rezende Barbosa 
Published: December 2022

Abstract

Objectives
Developing a hydrogel containing tea tree oil (TTO) encapsulated in solid lipid nanoparticles (SLNs) to treat oropharyngeal candidiasis.

Methods
Initially, the TTO chemical composition was evaluated. Next, SLNs containing TTO (TTO-SLNs) were produced and characterized. The TTO-SLNs were incorporated into a hydrogel, and the antifungal activity against Candida spp. was analysed. Finally, the ex vivo permeation was assessed.

Key findings
The chemical composition of TTO met ISO 4730:2017 standards. The TTO-SLNs were spherical and had a Z-average, PdI, ZP and entrapment efficiency of 135.90 ± 6.65 nm, 0.19 ± 0.04, −31.07 ± 1.05 mV and 92.74% ± 0.01%, respectively. Moreover, TTO-SLNs were stable (no changes in Z-average and PdI) for at least 120 days. In the cytotoxicity evaluation, the samples were considered cytotoxic at the following concentrations: TTO: 125–1000 µg/ml, TTO-SLN: 348–5568 µg/ml of TTO and the control nanoparticle was not cytotoxic. Both TTO-SLNs and the hydrogel containing TTO-SLNs demonstrated fungicidal action against all Candida spp., whilst for TTO, it was found only against C. albicans. The percentage of TTO permeation was 70.52%.

Conclusions
The hydrogel loaded with TTO-SLNs is a promising tool for TTO delivery, aiming at activity against C. albicans for the treatment of oropharyngeal candidiasis.
Bone Marrow Mesenchymal Stem Cells-Derived miR-21-5p Protects Grafted Islets Against Apoptosis by Targeting PDCD4
Authors: Wang Jingwen , Wang Jiale , Wang Ying , Ma Ruiyang , Zhang Shucong , Zheng Jin , Xue Wujun , Ding Xiaoming 
Published: December 2022

AbstractThe apoptosis of grafted islets is an urgent problem due to the high rate of islet loss soon after transplantation. MicroRNA-21-5p (miR-21-5p) is an essential mediator of bone marrow mesenchymal stem cells-derived exosomes (BMSCs-Exo) during anti-apoptosis, but its effect and the underlying molecular mechanism in islet transplantation remain partially understood. Here, we found that miR-21-5p could be delivered to islet cells via BMSCs-Exo. Subsequently, we demonstrated that miR-21-5p overexpression reduced apoptosis in islets and INS-1 cells, whereas miR-21-5p inhibition enhanced apoptosis. A mechanistic analysis involving RNA sequencing and bioinformatic analysis was performed to determine the interaction between miR-21-5p and its target gene programmed cell death 4 (PDCD4), which was further verified by a dual luciferase assay. In vivo, the grafted islets overexpressing miR-21-5p showed a higher survival rate, better insulin secretion function, and a lower apoptosis rate. In conclusion, these results demonstrated that miR‑21‑5p from BMSCs-Exo protects against the apoptosis of grafted islets by inhibiting PDCD4 expression. Hence, miR-21-5p can be used as a cell-free therapeutic agent to minimize β-cell apoptosis at the early stage of islet transplantation.