bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twenty-Four Hour Blood Pressure Response to Empagliflozin and Its Determinants in Normotensive Non-diabetic Subjects
Authors: Zanchi Anne , Pruijm Menno , Muller Marie-Eve , Ghajarzadeh-Wurzner Arlène , Maillard Marc , Dufour Nathalie , Bonny Olivier , Wuerzner Grégoire , Burnier Michel 
Published: March 2022

BackgroundSodium–glucose co-transport 2 inhibitors (SGLT2i) lower blood pressure (BP) in normotensive subjects and in hypertensive and normotensive diabetic and non-diabetic patients. However, the mechanisms of these BP changes are not fully understood. Therefore, we examined the clinical and biochemical determinants of the BP response to empagliflozin based on 24-h ambulatory BP monitoring.MethodsIn this post-hoc analysis of a double-blind, randomized, placebo-controlled study examining the renal effects of empagliflozin 10 mg vs. placebo in untreated normotensive non-diabetic subjects, the 1-month changes in 24 h ambulatory BP were analyzed in 39 subjects (13 placebo/26 empagliflozin) in regard to changes in biochemical and hormonal parameters.ResultsAt 1 month, empagliflozin 10 mg decreased 24-h systolic (SBP) and diastolic (DBP) BP significantly by −5 ± 7 mmHg (p &lt; 0.001) and −2 ± 6 mmHg (p = 0.03). The effect on SBP and DBP was more pronounced during nighttime (resp. −6 ± 11 mmHg, p = 0.004; −4 ± 7 mmHg, p = 0.007). The main determinants of daytime and nighttime SBP and DBP responses were baseline BP levels (for daytime SBP: coefficient −0.5; adj. R2: 0.36; p = 0.0007; for night-time SBP: coefficient −0.6; adj. R2: 0.33; p = 0.001). Although empaglifozin induced significant biochemical changes, none correlated with blood pressure changes including urinary sodium, lithium, glucose and urate excretion and free water clearance. Plasma renin activity and plasma aldosterone levels increased significantly at 1 month suggesting plasma volume contraction, while plasma metanephrine and copeptin levels remained the same. Renal resistive indexes did not change with empagliflozin.ConclusionSGLT2 inhibition lowers daytime and nighttime ambulatory systolic and diastolic BP in normotensive non-diabetic subjects. Twenty-four jour changes are pronounced and comparable to those described in diabetic or hypertensive subjects. Baseline ambulatory BP was the only identified determinant of systolic and diastolic BP response. This suggests that still other factors than sustained glycosuria or proximal sodium excretion may contribute to the resetting to lower blood pressure levels with SGLT2 inhibition.Clinical Trial Registration:[https://www.clinicaltrials.gov], identifier [NCT03093103].
Differential Influence of the COVID-19 Pandemic on Mechanical Thrombectomy and Bridging Therapy for Acute Ischemic Stroke
Authors: Geng Dandan , Xu Xueqian , Luan Xiaoqian , Qiu Linan , Chen Liuzhu , Chen Jiahao , Wu Beilan , Xu Minjie , Ergashev Akmal , Tang Wenjie , Li Jia 
Published: March 2022

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic is having a dramatic impact on acute stroke care. Its effects may accompany stroke care for a long time. We compared the treatment, short-term and long-term functional outcomes of patients with AIS from 2019 to 2020. Our objective was to evaluate the effect of COVID-19 epidemic on mechanical thrombectomy (MT) in patients in our hospital.MethodsWe collected information on subjects treated with MT in 2019–2020, including age, sex, time from the onset to arterial sheath insertion, time from the onset to recanalization, the rate of lung infection and hemorrhagic transformation, modified Rankin scale (mRS), NHISS, and ASPECTS.ResultsThe number of patients with MT decreased significantly by 26.6% in 2020 (p = 0.025). The pretreatment ASPECTS score for 2020 was significantly higher than 2019 (p = 0.004). Besides, the patients were more likely to develop lung infection (65 vs. 54.1%, p = 0.042) and had a higher risk of hemorrhagic transformation (47.4% vs. 30.4%, p = 0.005) in 2019. The discharged mRS reflected the worse short-term functional prognosis of patients with MT in 2019 (66 vs. 44.9%, p = 0.046). In the subgroup analysis of bridging thrombolysis (BT), more patients with BT are expected to have a poor short-term functional prognosis in 2020, according to the discharged mRS (62.5 vs. 37.5%, p = 0.024). However, there was no difference in mRS at 180 days between the two groups (p = 0.094).ConclusionFor patients with MT, both short- and long-term functional outcomes were not significantly affected due to the mild condition of patients admitted to hospital in 2020. For patients with BT, the COVID-19 pandemic has prolonged the green channel time of stroke, leading to a poor short-term functional prognosis of patients with stroke in the pandemic period. There was no difference in the effectiveness of direct MT and BT during the COVID-19 pandemic.
Juxtaposing Medical Centers Using Different Questionnaires Through Score Predictors
Authors: Puga Clara , Schleicher Miro , Niemann Uli , Unnikrishnan Vishnu , Boecking Benjamin , Brueggemann Petra , Simoes Jorge , Langguth Berthold , Schlee Winfried , Mazurek Birgit , Spiliopoulou Myra 
Published: March 2022

BackgroundChronic tinnitus is a clinically multidimensional phenomenon that entails audiological, psychological and somatosensory components. Previous research has demonstrated age and female gender as potential risk factors, although studies to this regard are heterogeneous. Moreover, whilst recent research has begun to identify clinical “phenotypes,” little is known about differences in patient population profiles at geographically separated and specialized treatment centers. Identifying such differences might prevent potential biases in joint randomized controlled trials (RCTs) and allow for population-specific treatment adaptations.MethodTwo German tinnitus treatment centers were compared regarding pre-treatment data distributions of their patient population bases. To identify overlapping as well as center-specific factors, juxtaposition-, similarity-, and meta-data-based methods were applied.ResultsBetween centers, significant differences emerged. One center demonstrated some predictive power of the patients of the other center with regard to questionnaire score after treatment, indicating similarities in treatment response across center populations. Furthermore, adherence to the completion of the questionnaires was found to be an important factor in predicting post-treatment data.DiscussionDifferential age and gender distributions per center should be considered as regards RCT design and individualized treatment planning.
Effects of Ramadan and Non-ramadan Intermittent Fasting on Gut Microbiome
Authors: Mousavi Seyedeh Neda , Rayyani Elham , Heshmati Javad , Tavasolian Ronia , Rahimlou Mehran 
Published: March 2022

BackgroundIn recent years, intermittent fasting (IF) has gained popularity in the health and wellness in the world. There are numerous types of IF, all of which involve fasting periods that last longer than an overnight fast and involve limited meal time-windows, with or without calorie restriction. The objective of this review is to summarize the current evidence for the effects of Ramadan and non-Ramadan IF on gut microbiome.MethodsWe explored PubMed, Scopus, Web of Science, and Google Scholar according to the PRISMA criteria (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). Animal and human studies were screened and reviewed separately by two researchers.ResultsTwenty-eight studies were selected after screening. Some of the studies were performed on animal models and some on humans. The results of these studies indicate a significant shift in the gut microbiota, especially an increase in the abundance of Lactobacillus and Bifidobacteria following fasting diets. The results of some studies also showed an increase in the bacterial diversity, decrease inflammation and increased production of some metabolites such as short-chain fatty acids (SCFAs) in individuals or samples under fasting diets. Moreover, Ramadan fasting, as a kind of IF, improves health parameters through positive effects on some bacterial strains such as Akkermansia muciniphila and Bacteroide. However, some studies have reported adverse effects of fasting diets on the structure of the microbiome.ConclusionIn general, most studies have seen favorable results following adherence from the fasting diets on the intestinal microbiome. However, because more studies have been done on animal models, more human studies are needed to prove the results.
Deep Infiltrating Endometriosis Malignant Invasion of Cervical Wall and Rectal Wall With Lynch Syndrome： A Rare Case Report and Review of Literature
Authors: Li Baoxuan , Wang Yang , Wang Yue , Li Siman , Liu Kuiran 
Published: March 2022

BackgroundMalignant transformation of deep infiltrating endometriosis (DIE) invading the cervix and rectum is quite rare, especially in patients combined with Lynch syndrome (LS). We report a rare case of a 49-year-old perimenopausal woman with endometrioid carcinoma arising from the pouch of Douglas, invading the cervix and rectum 1 year after a unilateral salpingo-oophorectomy treatment for ovarian endometriosis. The genetic testing of the patient showed germline mutations in MSH2, which combined with the special family history of colorectal cancer of the patient, was also thought to be associated with LS. We have analyzed the reported cases of DIE malignant transformation over the last 10 years, and reviewed the relevant literature, in order to strengthen the clinical management of patients with endometriosis, particularly patients with DIE, and reveal a possible correlation between malignant transformation of endometriosis and LS.Case PresentationA 49-year-old perimenopausal woman presented with hypogastralgia, diarrhea, and intermittent fever for more than 1 month. A Transvaginal ultrasound (TVS) showed a cervix isthmus mass, and a magnetic resonance imaging (MRI) showed a mass in pouch of Douglas with high suspicion of malignancy, possibly invading the anterior wall of the rectum. Prior to surgery, the patient performed the ultrasound guided pelvic mass biopsy through the vagina, and the pathology of the mass showed endometrioid carcinoma. The patient received a gynecological–surgical laparotomy and enterostomy, and a histopathology revealed endometrioid carcinoma infiltrating the cervical wall and rectal wall. In the family genetic history of the patient, her mother and two sisters suffered from colorectal cancer, so lesion tissue and blood were taken for genetic testing, which showed a germline mutation in MSH2, with LS being considered. After the surgical treatment, the patient received six courses of paclitaxel–carboplatin chemotherapy. During the course of treatment, bone marrow suppression occurred, but was healed after symptomatic treatment. To date, the patient is generally in good health, and imaging examination showed no evidence of recurrence.ConclusionThe risk of malignant transformation of endometriosis is increased in perimenopause and postmenopause, as DIE is a rare malignant transformation of endometriosis. DIE can invade other adjacent organs and cause poor prognosis, thus, comprehensive gynecological–surgical treatment should be necessary. In addition, if histopathology showed endometrioid carcinoma, the possibility of LS should be considered, and if necessary, immunohistochemical staining and gene detection should be improved to provide follow-up targeted therapy and immunotherapy.
Bispecific Antibodies Progression in Malignant Melanoma
Authors: Tang Juan , Gong Youling , Ma Xuelei 
Published: March 2022

The discovery of oncogenes and immune checkpoints has revolutionized the treatment of melanoma in the past 10 years. However, the current PD-L1 checkpoints lack specificity for tumors and target normal cells expressing PD-L1, thus reducing the efficacy on malignant melanoma and increasing the side effects. In addition, the treatment options for primary or secondary drug-resistant melanoma are limited. Bispecific antibodies bind tumor cells and immune cells by simultaneously targeting two antigens, enhancing the anti-tumor targeting effect and cytotoxicity and reducing drug-resistance in malignant melanoma, thus representing an emerging strategy to improve the clinical efficacy. This review focused on the treatment of malignant melanoma by bispecific antibodies and summarized the effective results of the experiments that have been conducted, also discussing the different aspects of these therapies. The role of the melanoma epitopes, immune cell activation, cell death and cytotoxicity induced by bispecific antibodies were evaluated in the clinical or preclinical stage, as these therapies appear to be the most suitable in the treatment of malignant melanoma.
Miscarriage: Marking Time
Authors: Занько С.Н. , Жабченко И.А. , Журавлев А.Ю. 
Published: March 2022

Преждевременные роды (ПР) были, есть и будут самой важной проблемой современного акушерства, ибо подавляющее большинство перинатальных потерь определяется недоношенностью новорожденных.По точному определению известного в мире специалиста G.C. Di Renzo на Всемирном конгрессе COGI: преждевременные роды (ПР): причины – неясные, диагностика – затруднена, методы – дискутабельны, результаты – непредсказуемы, цена – огромная.Нами проведено пилотное исследование совместного использования вагинального прогестерона и акушерского пессария. Полученные результаты вселяют оптимизм и позволяют рекомендовать подходы, которые описаны выше, к широкому медицинскому использованию. Предлагаемая медицинская технология утверждена Министерством здравоохранения Республики Беларусь в качестве инструкции по применению.
Preterm labor (PL) was, is and will be the most important problem of modern obstetrics, because the overwhelming majority of perinatal losses are determined by the prematurity of newborns.According to the exact definition of the world-famous specialist G. C. Di Renzo at COGI World Congress: preterm labor (PL): the reasons are unclear, the diagnosis is difficult, the methods are debatable, the results are unpredictable, the price is huge.We have conducted a pilot study of the combined use of vaginal progesterone and obstetrical pessary. The obtained results are encouraging and allow us to recommend the described above approaches for wide medical use. The proposed medical technology is approved by the Ministry of Health of the Republic of Belarus as an instruction for use.
Contemporary Approach towards Etiology, Pathogenesis and Classification of Ovarian Hyperstimulation Syndrome (Review)
Authors: Жуковская С.В.мл , Жуковская С.В. 
Published: March 2022

Синдром гиперстимуляции яичников (СГЯ) – одно из наиболее опасных ятрогенных осложнений контролируемой овариальной стимуляции в программах вспомогательных репродуктивных технологий (ВРТ). Частота возникновения СГЯ составляет до 33% от всех циклов ВРТ. СГЯ – сложный многозвеньевой процесс, начинающийся с супрафизологической концентрации гормонов как экзогенной, так и эндогенной природы, что приводит к синтезу и высвобождению биологически активных веществ и провоспалительных медиаторов (СЭФР, растворимый сосудистый эндотелиальный кадгерин, ИЛ-1, ИЛ-2, ИЛ-6, ИЛ-8, трансформирующий ростовой фактор-бета и др.), а также к чрезмерной активации ренин-ангиотензин-альдостероновой системы. Системная эндотелиальная дисфункция становится причиной повышения проницаемости капилляров, что является ключевым звеном в возникновении характерной клинической картины: гиповолемии, гемоконцентрации, абдоминального компартмент-синдрома, системного воспалительного ответа и развития полиорганной недостаточности, манифестирующей с острого повреждения почек и нередко приводящей к тромбоэмболическим осложнениям и острому респираторному дистресс-синдрому.Ovarian hyperstimulation syndrome (OHSS) is one of the most dangerous iatrogenic complications of controlled ovarian stimulation in assisted reproductive technologies (ART). The prevalence of this pathology is considerably high – it constitutes up to 33% of all ART procedures. OHSS is a complex multistage process caused by supraphysiological concentrations of exogenous and endogenous hormones, which leads to increased production and release of biologically active substances and proinflammatory mediators (VEGF, soluble VE-cadherin, IL-1, IL-2, IL-6, IL-8, transforming growth factor-beta, etc.), and to hyperactivation of renin-angiotensin-aldosterone system. Systemic endothelial dysfunction leads to excessive capillary permeability, which becomes a key point in OHSS pathogenesis and clinical presentation including hypovolemia, hemoconcentration, abdominal compartment syndrome, systemic inflammatory response and multiple organ dysfunction that commonly presents with acute kidney injury and leads to thromboembolism and acute respiratory distress syndrome.
Characterization of electronic charged states of high density self-aligned Si-based quantum dots evaluated with AFM/Kelvin probe technique
Authors: Imai Yuki , Makihara Katsunori , Taoka Noriyuki , Ohta Akio , Miyazaki Seiichi 
Published: March 2022

Abstract
We have characterized charged states of a self-aligned Si quantum dot (QD) structure with an areal density as high as ∼1013 cm−2 by surface potential measurements by using atomic force microscopy (AFM)/Kelvin probe force microscopy (KFM). By line scanning with the electrically-biased AFM tip with respect to the substrate in a contact mode, the corresponding area was negatively charged caused by electron injection from the tip into QDs. Cross-sectional profiles of the surface potential were clearly changed, which depends on the tip bias voltages. Also, a stepwise shape in a relationship between the change of the surface potential (ΔV) and the tip bias voltages was observed, reflecting electron charging into the discrete energy levels due to the quantum confinement effect. By assuming a simple equivalent circuit model for KFM measurements of the self-aligned Si-QDs, calculated results for ΔV are in good agreement with the measured results. The agreements precisely clarified the charged states in Si-QDs.
THE PRACTICE OF VALUES – ISLAMIC VALUES IN PODCAST CONTENT "KEJAR PAKET PINTAR" ON SPOTIFY AND HELP AKHLAKUL KARIMAH CHARACTERS OF ISLAMIC VALUE AGAINST MILLENNIALS
Authors: M. Nashoihul Ibad  
Published: March 2022

Abstract
Podcasts are a form of audio content that is a trend enjoyed by millennials in Indonesia. Content on the internet is increasingly diverse types, audio content is becoming increasingly to be accessed in addition to content in the form of videos such as on Youtube. Listeners' interest in Podcasts one that can be mentioned is the flexibility of its nature, meaning podcast audio can be enjoyed anytime and anywhere, even if sambal does. Work activities or time to rest unwind after work and allow it to be enjoyed as a process to deliver to sleep. This research aims to analyze the values of Islamic da'wah in podcast content that has the potential as a medium for broadcasting Islamic communication. The method used in this research is to use a literature review covering the process of deepening reading and understanding previous studies and analysis of articles. in journals, reference books, research on similar previous research, and Podcast material from Spotify as analysis material.
Understanding How Fast Black Holes Spin by Analyzing Data from the Second Gravitational-wave Catalogue
Authors: Hoy Charlie , Fairhurst Stephen , Hannam Mark , Tiwari Vaibhav 
Published: March 2022

Abstract
The Advanced LIGO and Virgo detectors have now observed approximately 50 black hole binary mergers, from which we can begin to infer how rapidly astrophysical black holes spin. The LIGO-Virgo Collaboration (LVC) analysis of detections up to the end of the first half of the third observing run (O3a) appeared to uncover a distribution of spin magnitudes that peaks at ∼0.2. This is surprising: is there a black hole formation mechanism that prefers a particular, nonzero spin magnitude, or could this be the cumulative effect of multiple formation processes? We perform an independent analysis of the most recent gravitational-wave (GW) catalog, and find that (a) the support for the LVC spin magnitude is tenuous; in particular, adding or removing just one signal from the catalog can remove the statistical preference for this distribution; and (b) we find potential evidence for two spin subpopulations in the observed black holes: one with extremely low spins and one with larger spin magnitudes. We make the connection that these spin subpopulations could be correlated with the mass of the binary, with more massive binaries preferring larger spin magnitudes, and argue that this may provide evidence for hierarchical mergers in the second GW catalog.
Analytic Solution to the Dynamical Friction Acting on Circularly Moving Perturbers
Authors: Desjacques Vincent , Nusser Adi , Bühler Robin 
Published: March 2022

Abstract
We present an analytic approach to the dynamical friction (DF) acting on a circularly moving point mass perturber in a gaseous medium. We demonstrate that, when the perturber is turned on at t = 0, steady state (infinite time perturbation) is achieved after exactly one sound-crossing time. At low Mach numbers

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≪
1

, the circular-motion steady-state DF converges to the linear-motion, finite time perturbation expression. The analytic results describe both the radial and tangential forces on the perturbers caused by the backreaction of the wake propagating in the medium. The radial force is directed inward, toward the motion center, and is dominant at large Mach numbers. For subsonic motion, this component is negligible. For moderate and low Mach numbers, the tangential force is stronger and opposes the motion of the perturber. The analytic solution to the circular-orbit DF suffers from a logarithmic divergence in the supersonic regime. This divergence appears at short distances from the perturber solely (unlike the linear-motion result, which is also divergent at large distances) and can be encoded in a maximum multipole. This is helpful to assess the resolution dependence of numerical simulations implementing DF at the level of Liénard–Wiechert potentials. We also show how our approach can be generalized to calculate the DF acting on a compact circular binary.
New Pulsating Stars Detected in EA-type Eclipsing-binary Systems Based on TESS Data
Authors: Shi 施 Xiang-dong 相东 , Qian 钱 Sheng-bang 声帮 , Li 李 Lin-Jia 临甲 
Published: March 2022

Abstract
Pulsating stars in eclipsing binaries are very important for understanding the structure of stellar interiors through asteroseismology because their absolute parameters such as their masses and radii can be determined with high precision based on photometric and spectroscopic data. The high-precision and continuous time-series photometric data of the Transiting Exoplanet Survey Satellite (TESS) provides an unprecedented opportunity to search for and study these kinds of variable stars in the whole sky. About 1626 Algol-type (EA-type) eclipsing-binary systems were observed by TESS in the 1–45 sectors with 2 minutes short cadence. By analyzing these TESS data, we found 57 new pulsating stars in EA-type binary stars. The preliminary results show that these binary systems have orbital periods in the range from 0.4 to 27 days, while the periods of pulsating components are in the range from 0.02 to 5 days. It is detected that 43 targets follow the correlation between the pulsation and orbital periods of Algol-type oscillating eclipsing binaries (oEA stars), which may indicate that they are typical oEA stars. The other 14 targets may be other types of variable stars in eclipsing-binary systems. These objects are a very interesting source to investigate binary structures and evolution as well as to understand the influences of tidal forces and mass transfer on stellar pulsations.