bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of cardiovascular diseases mortality- and disability-adjusted life-years attributed to modifiable dietary risk factors from 1990 to 2030 among East Asian countries and the world
Authors: Nawsherwan  , Bin Wang , Le Zhang , Mubarik Sumaira , Fu Guo , Wang Yan 
Published: October 2022

BackgroundUnhealthy eating habits are a significant modifiable risk factor for cardiovascular diseases (CVDs); nevertheless, no evidence of their impact on the CVD burden has been reported in East Asian countries. We aimed to determine the trend and predict the future CVDs burden attributed to modifiable dietary risk factors in the East Asian countries (China, Japan, South Korea, and North Korea) and the world.MethodsThe Global Burden of Disease (GBD) 2019 data were used to find the trend of CVDs [ischemic heart disease (IHD) and ischemic stroke (IS)] mortality- and disability-adjusted life-years (DALYs) attributed to dietary risk factors in the East Asian countries and the world (1990–2019) and its prediction from 2020 to 2030. We used the joinpoint regression model and the autoregressive integrated moving average (ARIMA) model for trend and future forecast, respectively.ResultsFrom 1990 to 2019, regardless of sex, the age-standardized mortality rate (ASMR) and DALYs of IHD attributed to dietary risk factors significantly decreased in Japan, South Korea, and the world. However, the ASMR of IHD significantly increased in Chinese males and for both sexes in North Korea. The ASMR and DALYs of IHD and IS due to dietary risk factors were higher in males than in females in the world. From 2020 to 2030, the ASMR of IHD is predicted to increase in South Korean females and Japanese males. Globally, a diet low in whole grains was the top risk factor for the highest IHD mortality and DALYs in 2019, followed by a diet low in legumes and a diet high in sodium. A diet low in whole grains, a diet high in sodium, and a diet low in legumes were the leading risk factors for high IHD mortality in East Asian countries.ConclusionThe trend of IHD and IS burden due to dietary risk factors varies substantially across the East Asian countries compared to the trend of CVDs burden in the world. The study findings may help the public health policymakers to design proper strategies for improvement of the quality of life to combat the CVDs burden in the future for the East Asian countries.
Evaluating the impact of pop-off mechanisms in boys with posterior urethral valves
Authors: Delefortrie T. , Ferdynus C. , Paye-Jaouen A. , Michel J. L. , Dobremez E. , Peycelon M. , El Ghoneimi A. , Harper L. 
Published: October 2022

IntroductionPosterior urethral valves are urethral leaflets that cause Lower Urinary Tract Obstruction (LUTO) in boys and are associated with congenital renal dysplasia and abnormal bladder function. They affect 1:4,000 to 1:25,000 births and can be responsible for End-Stage Renal Failure in childhood. There have been several studies on the effect of pop-off mechanisms in boys with posterior urethral valves, but results are contradictory. We aimed to assess and discuss the effect of pop-off mechanisms on renal function in a large cohort of patients.Patients and methodBoys with PUV with and without pop-off mechanisms (urinoma, VURD or giant bladder diverticula) were divided into three severity groups for renal function according to their nadir creatinine (low-risk NC &lt; 35 μmol/L, intermediate-risk NC between 35 and 75 μmol/L, and high-risk NC &gt; 75 μmol/L). We compared children with and children without pop-off mechanisms for mean renal function as well as patient distribution within each severity group.ResultsWe included 137 boys of which 39 had a pop-off mechanism. Patients had complete data for at least 5 years follow-up. Though there was no significant statistical difference in mean renal function between the pop-off and non-pop-off group, patient distribution within each severity group varied according to whether patients had a pop-off mechanism or not.ConclusionThough there was no significant difference in mean renal function between boys with and without pop-off mechanisms, it is possible that these are two different patient populations and direct comparison is not possible.
Outcomes of sonographically-suspected fetal intra-abdominal cysts: Surgical intervention, conservative management and spontaneous regression
Authors: Gai Shuangshuang , Wang Lixiu , Zheng Weizeng , Xu Bin , Luo Qiong , Qin Jiale 
Published: October 2022

ObjectiveThe prenatal diagnosis of fetal intra-abdominal cysts is challenging. This study aimed to evaluate the diagnostic ability of prenatal ultrasound for fetal intra-abdominal cysts and to develop a predictive method for pre- and postnatal outcomes.MethodsWe retrospectively reviewed fetuses with ultrasound-detected intra-abdominal cysts between January 2013 and January 2020. The maternal–fetal clinical characteristics and ultrasound parameters were integrated into a model of pre- or postnatal outcomes.ResultsThe study enrolled 190 eligible fetuses, including 94 cases of spontaneous regression, 33 cases of conservative management and 63 cases of surgical intervention. For the 63 cases of surgical intervention, prenatal ultrasound was found to identify fetal intra-abdominal cysts with 80.00% sensitivity (95% CI: 67.03%–89.57%), 37.50% specificity (95% CI: 8.52%–75.51%), 89.80% positive predictive value (95% CI: 83.51%–93.86%), 21.43% negative predictive value (95% CI: 8.80%–43.53%) and 74.60% accuracy (95% CI: 62.06%–84.73%). The predictive model of prenatal spontaneous regression was as follows: y = −3.291 + 0.083 × gestational age + 1.252 × initial diameter, with an area under the curve (AUC) of 0.819 (95% CI: 0.739–0.899) and an optimal cut-off value of 0.74. The large cyst diameter before delivery was an independent predictor of postnatal surgical intervention (p &lt; 0.001), with an AUC of 0.710 (95% CI: 0.625–0.794) and an optimal cut-off value of 3.35 cm.ConclusionAlthough ultrasound has a limited ability in the accurate diagnosis of fetal abdominal cysts, a simple method of measuring the diameter can predict fetal outcomes and identify the cases that may require surgical intervention or spontaneous regression.
Genome-wide association study for resistance to Pseudomonas syringae pv. garcae in Coffea arabica
Authors: Ariyoshi Caroline , Sant’ana Gustavo César , Felicio Mariane Silva , Sera Gustavo Hiroshi , Nogueira Livia Maria , Rodrigues Lucas Mateus Rivero , Ferreira Rafaelle Vecchia , da Silva Bruna Silvestre Rodrigues , Resende Mário Lúcio Vilela de , Destéfano Suzete Aparecida Lanza , Domingues Douglas Silva , Pereira Luiz Filipe Protasio 
Published: October 2022

Bacteria halo blight (BHB), a coffee plant disease caused by Pseudomonas syringae pv. garcae, has been gaining importance in producing mountain regions and mild temperatures areas as well as in coffee nurseries. Most Coffea arabica cultivars are susceptible to this disease. In contrast, a great source of genetic diversity and resistance to BHB are found in C. arabica Ethiopian accessions. Aiming to identify quantitative trait nucleotides (QTNs) associated with resistance to BHB and the influence of these genomic regions during the domestication of C. arabica, we conducted an analysis of population structure and a Genome-Wide Association Study (GWAS). For this, we used genotyping by sequencing (GBS) and phenotyping for resistance to BHB of a panel with 120 C. arabica Ethiopian accessions from a historical FAO collection, 11 C. arabica cultivars, and the BA-10 genotype. Population structure analysis based on single-nucleotide polymorphisms (SNPs) markers showed that the 132 accessions are divided into 3 clusters: most wild Ethiopian accessions, domesticated Ethiopian accessions, and cultivars. GWAS, using the single-locus model MLM and the multi-locus models mrMLM, FASTmrMLM, FASTmrEMMA, and ISIS EM-BLASSO, identified 11 QTNs associated with resistance to BHB. Among these QTNs, the four with the highest values of association for resistance to BHB are linked to g000 (Chr_0_434_435) and g010741 genes, which are predicted to encode a serine/threonine-kinase protein and a nucleotide binding site leucine-rich repeat (NBS-LRR), respectively. These genes displayed a similar transcriptional downregulation profile in a C. arabica susceptible cultivar and in a C. arabica cultivar with quantitative resistance, when infected with P. syringae pv. garcae. However, peaks of upregulation were observed in a C. arabica cultivar with qualitative resistance, for both genes. Our results provide SNPs that have potential for application in Marker Assisted Selection (MAS) and expand our understanding about the complex genetic control of the resistance to BHB in C. arabica. In addition, the findings contribute to increasing understanding of the C. arabica domestication history.
High-throughput generation of microfluidic-templating microgels for large-scale single-cell encapsulation
Authors: Zhang Haoyue , Li Chengze , Zhang Yujie , An Chuanfeng , Li Hanting , Yu Jiahui , Zhang Yonghao , He Wei , Wang Huanan 
Published: October 2022

Microfluidics-based fabrication of cell-laden microgels has shown great potential for applications in cell therapy and tissue engineering, however, the difficulty in chip operation and compromised cell viability due to cell sedimentation and channel blockage remain a major challenge for functional cell-laden microgels preparation. Herein, we presented the design and optimization of integrated microfluidic chip for large-scale preparation of cell-laden microgels with controllable size and complex microstructure. Specifically, to avoid severe cell sedimentation and uneven distribution in the parallelized microchannel, we simulated cell movement state using computational fluid dynamics simulation. It was found that higher laminar flow velocity gradient and higher precursor viscosity can significantly improve the uniform cell distribution in parallelized channels and reduce the product difference between channels. Moreover, we designed multiple-layered microfluidic chips allowing multiple inputting liquids for the fabrication of microgels with complex structures. This integrated chip facilitated cell encapsulation at a maximum production rate of 240 ml/h of cell suspension with retained cell viability and functionality. Therefore, our study provided a biocompatible and high-throughput strategy for large-scale preparation of cell-laden microgels, which can enable significant advances for clinical-relevant applications of cell-laden microgels, including cell therapy, tissue regeneration and 3D bioprinting.
Eccentric distance zone analysis system: New regional evaluation of cephalic fixator tip location for predicting cut-out in geriatric intertrochanteric fractures with internal fixation
Authors: Yang Yun-fa , Huang Jian-wen , Gao Xiao-sheng , Xu Zhong-he 
Published: October 2022

ObjectiveThe aim of this study was to investigate an eccentric distance (ED) zone analysis system for regional evaluation of the cephalic fixator tip based on the ED of the cephalic fixator tip referenced to the radius of its own femoral head to predict cut-out in intertrochanteric fractures (ITF) with internal fixation.MethodsFirst, we assumed all the femoral heads were regular spheres with the radius (RFD) of “3” for a complete match of the Cleveland zone system and calculated the ED of the cephalic fixator tip by measuring the distances from the cephalic fixator tip to the geometric central axis in the femoral neck and head on both anteroposterior (AP) view and lateral view radiographs. Second, we defined the maximum transverse section of the femoral head into three zones named ED Zone A with ED less than “1,” Zone B with ED ranging in “1–2,” and Zone C with ED ranging in “2–3” in turns by concentric circles (circles A, B, and C) with the radius of 1/3, 2/3, and 3/3 times of RFD, respectively. Third, we evaluated the ED zones according to the ED and location of the cephalic fixator tip in the eligible 123 ITF patients with single-screw cephalomedullary nail (SCMN) fixation and then analyzed the correlation between the cut-out rate and the ED zones.ResultsThe cut-out rates in ED Zones A, B, and C were 4.17%, 38.46%, and 100%, respectively. Multivariate logistic regression indicated that ED Zone A had at least a 14 times lower rate of cut-out compared with ED Zone B. The cephalic fixator tip located in ED Zone A has a lower cut-out rate than that in Cleveland Zone 5. The cut-out rate in ED Zone A is significantly lower than that in the region inside Cleveland Zone 5 but outside ED Zone A.ConclusionED zone analysis system is a reliable regional evaluation of the cephalic fixator tip position for predicting cut-out in geriatric ITF patients with SCMN fixations and potentially an artificial intelligence measurement during surgery. For decreasing the cut-out rate, the cephalic fixator tip should be located in ED Zone A.
Performance of the SCORE and Globorisk cardiovascular risk prediction models: a prospective cohort study in Dutch general practice
Authors: Schoofs Merle CA , Akkermans Reinier P , de Grauw Wim JC , Schalk Bianca WM , van Dis Ineke , Tjin-A-Ton Judith , Bischoff Erik WMA , Biermans Marion CJ 
Published: October 2022

BackgroundGPs frequently use 10-year-risk estimations of cardiovascular disease (CVD) to identify high- risk patients.AimTo assess the performance of four models for predicting the 10-year risk of CVD in Dutch general practice.Design and settingProspective cohort study. Routine data (2009– 2019) was used from 46 Dutch general practices linked to cause of death statistics.MethodThe outcome measures were fatal CVD for SCORE and first diagnosis of fatal or non- fatal CVD for SCORE fatal and non-fatal (SCORE- FNF), Globorisk-laboratory, and Globorisk-office. Model performance was assessed by examining discrimination and calibration.ResultsThe final number of patients for risk prediction was 1981 for SCORE and SCORE-FNF, 3588 for Globorisk-laboratory, and 4399 for Globorisk- office. The observed percentage of events was 18.6% (n= 353) for SCORE- FNF, 6.9% (n= 230) for Globorisk-laboratory, 7.9% (n= 323) for Globorisk-office, and 0.3% (n= 5) for SCORE. The models showed poor discrimination and calibration. The performance of SCORE could not be examined because of the limited number of fatal CVD events. SCORE-FNF, the model that is currently used for risk prediction of fatal plus non-fatal CVD in Dutch general practice, was found to underestimate the risk in all deciles of predicted risks.ConclusionWide eligibility criteria and a broad outcome measure contribute to the model applicability in daily practice. The restriction to fatal CVD outcomes of SCORE renders it less usable in routine Dutch general practice. The models seriously underestimate the 10-year risk of fatal plus non-fatal CVD in Dutch general practice. The poor model performance is possibly because of differences between patients that are eligible for risk prediction and the population that was used for model development. In addition, selection of higher-risk patients for CVD risk assessment by GPs may also contribute to the poor model performance.
Dampak Stock Split Terhadap Likuiditas Saham Pada Perusahaan Yang Terdaftar Di BEI Tahun 2016-2020
Authors: Muchran Muchriana , Imma Nurhikma , Idrawahyuni Idrawahyuni 
Published: October 2022

Tujuan dari penelitian ini yaitu untuk menguji bagaimana dampak pemecahan saham pada likuiditas saham di perusahaan yang tercatat di Bursa Efek Indonesia dari tahun 2016-2020. Sampel penelitian digunakan metode purposive sampling. Dari metode tersebut, diambil 57 perusahaan menjadi sampel penelitian. Metode dokumentasi dan studi pustaka merupakan metode yang dugunakan dalam pengumpulkan data. Dalam menguji hipotesis penelitian, peneliti menggunakan uji wilcoxon signed ranks sampel test untuk menguji hipotesis penelitian. Hasil penelitian menunjukkan bahwa likuiditas saham baik sebelum maupun sesudah stock split tanpa ditemukan selisih beda yang signifikan. Hal ini memperjelas bahwa pemecahan saham tidak berdampak pada likuiditas saham.Tujuan dari penelitian ini yaitu untuk menguji bagaimana dampak pemecahan saham pada likuiditas saham di perusahaan yang tercatat di Bursa Efek Indonesia dari tahun 2016-2020. Sampel penelitian digunakan metode purposive sampling. Dari metode tersebut, diambil 57 perusahaan menjadi sampel penelitian. Metode dokumentasi dan studi pustaka merupakan metode yang dugunakan dalam pengumpulkan data. Dalam menguji hipotesis penelitian, peneliti menggunakan uji wilcoxon signed ranks sampel test untuk menguji hipotesis penelitian. Hasil penelitian menunjukkan bahwa likuiditas saham baik sebelum maupun sesudah stock split tanpa ditemukan selisih beda yang signifikan. Hal ini memperjelas bahwa pemecahan saham tidak berdampak pada likuiditas saham.
Tecnología en la enseñanza de las personas con discapacidad en tiempo de pandemia
Authors: Tapia-Segarra Jenny Irlanda , Toledo-Moncayo Cecilia 
Published: October 2022

El objetivo fue analizar el uso de la tecnología en la enseñanza de las personas con discapacidad en tiempo de pandemia del Instituto de Parálisis Cerebral del Azuay. Para ello, se ha considerado importante aplicar el enfoque investigativo cuantitativo, mediante la aplicación de la técnica de la encuesta tomando con instrumento un cuestionario estructurado. De acuerdo a los resultados obtenidos, mediante la revisión bibliográfica se ha identificado que la tecnología tiene un aporte significativo en la enseñanza de las personas con discapacidad, el uso de los medios tecnológicos contribuye a mejorar la calidad de vida de las personas. Con los resultados obtenidos, se espera contribuir a futuras investigaciones que direccionen su estudio a las personas con discapacidad de acuerdo a los procesos de inclusión educativa que se vayan establecido en el sistema educativo.
Auditoría de gestión como herramienta de análisis de la cartera de crédito en empresas comerciales
Authors: Pacurucu-Arcentales Andrea Cristina , Narváez-Zurita Cecilia Ivonne 
Published: October 2022

La auditoría de gestión permite realizar una evaluación a la entidad o grupo de estudio específico, para establecer el grado de eficiencia, eficacia y economía de los procesos, y el uso de los recursos; de tal forma que los resultados obtenidos de esta evaluación se conviertan en bases, para planificar y elaborar consecutivamente un plan de mejora. Bajo este contexto, la presente investigación tiene como objetivo diseñar lineamientos estratégicos de Auditoria de Gestión, que propicien la optimización de la gestión de crédito de los concesionarios automotrices de la ciudad de Cuenca. El estudio se ejecutó con la participación de los concesionarios constituidos con personería jurídica, mediante la aplicación de un estudio no experimental con alcance descriptivo. Proponiendo varias técnicas o herramientas útiles para el control del proceso de la gestión de cartera como la observación, la verificación, el análisis, la comprobación, entre otros.
Strategi Penangan Permukiman di Kabupaten Jeneponto
Authors: Rahayu Rukni , Syafri Syafri , Salim Rasyidi Emil 
Published: October 2022

Abstract. The purpose of this study was to analyze the level of slums, determine the determinant factors and formulate strategies for preventing and improving the quality of settlements in the Allu area, Bangkala district, and Jeneponto district. This type of research is mixed method research. To analyze the level of slums in the Allu Area, Bangkala District, Jeneponto Regency using baseline scoring analysis, to determine the determinant factors that cause the level of slums, Multiple Linear Regression analysis is used and to determine the effect of the slum level. The main conclusion of this study is that based on the results of the baseline scoring analysis, it shows that the level of slums in the Allu Area, Bangkala District, and Jeneponto Regency is in the medium slum category. To find out the determinant factors that cause the level of slums in the Allu area are the condition of buildings, conditions of drinking water supply, environmental drainage conditions, wastewater treatment conditions, waste management conditions, fire protection, and land ownership status. The macro concept of handling slum areas in the allu area is prevention, restoration, and rejuvenation of the area.

Abstrak. Tujuan dari penelitian ini ialah untuk menganalisis tingkat kekumuhan, mengetahui faktor-faktor determinan dan merumuskan strategi pencegahan dan peningkatan kualitas permukiman di Kawasan Allu, Kecamatan Bangkala, Kabupaten Jeneponto. Jenis penelitian ini merupakan penelitian mix method. Untuk menganalisis tingkat kekumuhan di Kawasan Allu, Kecamatan Bangkala, Kabupaten Jeneponto menggunakan analisis skoring baseline, untuk mengetahui faktor determinan yang menyebabkan tingkat kekumuhan digunakan analisis Regresi Linear Berganda dan untuk mengetahui pengaruh tingkat kekumuhan. Kesimpulan utama dalam penelitian ini yaitu Berdasarkan hasil analisis skoring baseline menunjukkan bahwa tingkat kekumuhan di Kawasan Allu Kecamatan Bangkala Kabupaten Jeneponto masuk dalam kategori kumuh sedang. Untuk mengetahui faktor determinan yang menyebabkan tingkat kekumuhan di Kawasan Allu adalah kondisi bangunan gedung, kondisi penyediaan air minum, kondisi drainase lingkungan, kondisi pengolahan air limbah, kondisi pengolahan persampahan, proteksi kebakaran dan status kepemilikan lahan. Konsep makro penanganan kawasan kumuh di kawasan allu adalah: pencegahan, pemugaran, dan peremajaan kawasan.
Komputerisasi Akuntansi Pengendalian Persediaan Obat Di Apotek Lira Medika Berbasis VB,Net
Authors: Indaryono Indaryono , Rostiani Yeny , Yusuf Arif Maulana , Apriyani Pina Mega 
Published: October 2022

Persediaan merupakan salah satu aset penting yang harus dimiliki oleh perusahaan, karena persediaan adalah aset perusahaan sehingga harus memiliki pengendalian internal yang baik persediaan untuk menjaga mereka dari banyak hal-hal buruk yang mungkin terjadi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan pengendalian internal dan inventarisasi kendala barang dagangan dan usaha. Selain itu, tujuan dari penelitian ini adalah untuk analisis whather pengendalian internal atas persediaan yang ada di perusahaan adalah di accourdance dengan teori yang ada. Metode yang digunakan dalam penelitian ini adalah pendekatan deskriptif kualitatif. Dengan menggunakan metode analisis deskriptif pengumpulan data didukung oleh teori yang ada. Instrumen yang digunakan untuk mengumpulkan data adalah observasi, wawancara, dan dokumentasi. Dalam jenis data penelitian yang digunakan adalah data primer dan data sekunder. Penelitian ini dilakukan di Apotek Lira Medika. Berdasarkan hasil penelitian, dapat disimpulkan bahwa pengendalian internal Apotek Lira Medika memiliki operasi dukungan secara efektif, tetapi pekerjaan masih dilakukan oleh petugas yang sama, dengan kata lain ada tugas ganda.
KAJIAN SOSIOLINGUISTIK MASYARAKAT TRANSMIGRAN DI RIAU DAN RELEVANSINYA TERHADAP PEMBELAJARAN KETERAMPILAN BERBICARA BAHASA ARAB
Authors: Harimi Abdal Chaqil Harimi 
Published: October 2022

This Research explains about Used of language in Sari galuh Village Society. Researcher uses descriptive qualitative research with observation method, interview method, and documentation method.
Results of this reaserch are firts, There is Multilanguage. Because, a lot of people came in Sari galuh Village for Transmigration programe. They were from Medan, Java, Bukittinggi, and the original people in Riau. The multilanguage process is caused transmigration programe or migration in Sociolinguistic. The second result shows that Javanese and bahasa are most dominant languages in Sari Galuh village. Third, there is incfluences environment for language process in Sari Galuh Village. The succesfully in speaking learning skills can be approved with making arabic domination dan arabic environment in the class.
Keywords: Sociolinguistic, Language Domination, Speaking Skills