bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solar-Driven Photocatalytic Films: Synthesis Approaches, Factors Affecting Environmental Activity, and Characterization Features
Authors: Šuligoj Andraž , Cerc Korošec Romana , Žerjav Gregor , Novak Tušar Nataša , Lavrenčič Štangar Urška 
Published: October 2022

AbstractSolar-powered photocatalysis has come a long way since its humble beginnings in the 1990s, producing more than a thousand research papers per year over the past decade. In this review, immobilized photocatalysts operating under sunlight are highlighted. First, a literature review of solar-driven films is presented, along with some fundamental operational differences in relation to reactions involving suspended nanoparticles. Common strategies for achieving sunlight activity from films are then described, including doping, surface grafting, semiconductor coupling, and defect engineering. Synthetic routes to fabricate photocatalytically active films are briefly reviewed, followed by the important factors that determine solar photocatalysis efficiency, such as film thickness and structure. Finally, some important and specific characterization methods for films are described. This review shows that there are two main challenges in the study of photocatalytic materials in the form of (thin) films. First, the production of stable and efficient solar-driven films is still a challenge that requires an integrated approach from synthesis to characterization. The second is the difficulty in properly characterizing films. In any case, the research community needs to address these, as solar-driven photocatalytic films represent a viable option for sustainable air and water purification.
Fast Hubness-Reduced Nearest Neighbor Search for Entity Alignment in Knowledge Graphs
Authors: Obraczka Daniel , Rahm Erhard 
Published: October 2022

AbstractThe flexibility of Knowledge Graphs to represent heterogeneous entities and relations of many types is challenging for conventional data integration frameworks. In order to address this challenge the use of Knowledge Graph Embeddings (KGEs) to encode entities from different data sources into a common lower-dimensional embedding space has been a highly active research field. It was recently discovered however that KGEs suffer from the so-called hubness phenomenon. If a dataset suffers from hubness some entities become hubs, that dominate the nearest neighbor search results of the other entities. Since nearest neighbor search is an integral step in the entity alignment procedure when using KGEs, hubness is detrimental to the alignment quality. We investigate a variety of hubness reduction techniques and (approximate) nearest neighbor libraries to show we can perform hubness-reduced nearest neighbor search at practically no cost w.r.t speed, while reaping a significant improvement in quality. We ensure the statistical significance of our results with a Bayesian analysis. For practical use and future research we provide the open-source python library athttps://github.com/dobraczka/kiez.
Designing a RESTful Northbound Interface for Incompatible Software Defined Network Controllers
Authors: Alghamdi Abdullah , Paul David , Sadgrove Edmund 
Published: October 2022

AbstractIn Software Defined Networking, applications often need to communicate with network controllers to query or modify the current state of the network. However, there is currently no standard northbound interface that allows this communication to occur. Instead, each Software Defined Networking implementation defines its own interface, meaning applications typically need to be modified to allow them to work with different controllers. In this paper we present a high-level design for a REST-like reactive northbound interface which would allow applications to be written once and then work with multiple otherwise-incompatible controllers.
Visible light-driven degradation of Acid Orange 7 by light modulation techniques
Authors: Sannino Diana , Morante Nicola , Sacco Olga , Mancuso Antonietta , De Guglielmo Luca , Di Capua Giulia , Femia Nicola , Vaiano Vincenzo 
Published: October 2022

Abstract
The impact of light modulation on the decolorization of Acid Orange 7 (AO7) in aqueous solution was examined in this paper. A fixed bed batch photocatalytic reactor with a flat plate geometry, irradiated by 240 white-light LEDs, was used. A successful transfer of visible active photocatalyst (N-TiO2) in powder form on a polystyrene (PS) transparent plate was realized. The structured photocatalyst was characterized through SEM–EDX, Raman and UV-DRS analyses, evidencing the formation of a coating of N-TiO2 in the anatase phase, with a band-gap energy of 2.5 eV, and almost uniform distribution on the PS surface. Different LED dimming techniques, with fixed and variable duty-cycle values, were tested, and four types of light modulation were compared: fixed duty cycle (constant irradiation), sinusoidal variable duty cycle (sinusoidal variable irradiation), triangular variable duty cycle (triangular variable irradiation), and square wave variable duty cycle (square wave variable irradiation). The resulting responsiveness/efficiency of the LED versus the current intensity was evaluated, and the stability of the photocatalyst activity and the influence of optimized irradiation waveforms were examined in the decolorization of 400 mL of 10 ppm AO7 solution. The sinusoidal modulation, with current between 50 and 100 mA and 10 s as the period, shows the highest value of the apparent pseudo-first-order kinetic constant, resulting equal to 0.0044 min−1, at parity of total transmitted photons. An energy saving with the application of sinusoidal irradiation is highlighted with respect to the literature.

Graphical Abstract
Electrophysiology and fluorescence to investigate cation channels and transporters in isolated plant vacuoles
Authors: Gradogna Antonella , Carpaneto Armando 
Published: October 2022

AbstractThe plant vacuole plays a fundamental role in cell homeostasis. The successful application of patch-clamp technique on isolated vacuoles allows the determination of the functional characteristics of tonoplast ion channels and transporters. The parallel use of a sensor-based fluorescence approach capable of detecting changes in calcium and proton concentrations opens up new possibilities for investigation. In excised patch, the presence of fura-2 in the vacuolar solution reveals the direct permeation of calcium in plant TPC channels. In whole-vacuole, the activity of non-electrogenic NHX potassium proton antiporters can be measured by using the proton sensitive dye BCECF loaded in the vacuolar lumen by the patch pipette. Both vacuolar NHXs and CLCa (chloride/nitrate antiporter) are inhibited by the phosphoinositide PI(3,5)P2, suggesting a coordinated role of these proteins in salt accumulation. Increased knowledge in the molecular mechanisms of vacuolar ion channels and transporters has the potential to improve our understanding on how plants cope with a rapidly changing environment.
On some intracranialist dogmas in epistemology
Authors: Carter J. Adam 
Published: October 2022

Abstract
Research questions in mainstream epistemology often take for granted a cognitive internalist picture of the mind. Perhaps this is unsurprising given the seemingly safe presumptions that (i) knowledge entails belief (viz. the entailment thesis) and that (ii) the kind of belief that knowledge entails supervenes exclusively on brainbound cognition. It will be argued here that (contra orthodoxy) the most plausible version of the entailment thesis holds just that knowledge entails dispositional belief. However, regardless of whether occurrent belief supervenes only as the cognitive internalist permits, we should reject the idea that dispositional belief supervenes only in cognitive internalist-friendly ways. These observations, taken together, reveal two things: first, that a cognitive internalist picture of the mind is much more dispensable in epistemology than has been assumed and, second, that pursuing questions in extended epistemology need not involve any radical departure from the commitments of more traditional epistemological projects.
Analysis of Potential Precursory Pattern at Earth Surface and the Above Atmosphere and Ionosphere Preceding Two Mw ≥ 7 Earthquakes in Mexico in 2020–2021
Authors: Xu Xitong , Chen Shengbo , Zhang Sen , Dai Rui 
Published: October 2022

AbstractComprehensive analyses of seismic precursory characteristics may provide evidence for the possible mechanisms of lithosphere‐atmosphere‐ionosphere coupling (LAIC). The integrated monitoring data from space and ground measurements makes it possible to reveal the potential earthquake precursory pattern obeying LAIC. In this paper, we study seismic precursors from air temperature data of the National Center for Environmental Prediction (NCEP), Global Navigation Satellite System (GNSS) based Total Electron Content (TEC) and electron density retrieved from Swarm satellite (Alpha) data in two Mw 7.0 earthquakes in Mexico in 2020–2021. We find seismic thermal anomalies can be identified from temperature variation in the lithosphere and atmosphere by improved tidal force fluctuant analysis (TFFA). The spatial‐temporal evolution of seismic thermal anomalies is significantly different from that of non‐seismic thermal anomalies. In addition, synergistic observations of the Swarm Alpha satellite and GNSS stations can provide more comprehensive information about perturbations in the ionosphere. The results show that anomalies originate along fault lineaments near the epicenter, leading to air pressure gradient and ionization process in the atmosphere, followed by ionospheric perturbations. Furthermore, composite anomalies of LAIC first appear around a month before earthquakes and tend to recur several times over earthquake preparation phases. Our study provides more evidence for understanding the characteristics of earthquake precursors.
Coalescence of Growing Bubbles in Highly Viscous Liquids
Authors: Ohashi Masatoshi , Maruishi Takafumi , Toramaru Atsushi 
Published: October 2022

AbstractBubble coalescence in ascending magma is a key process that controls the eruption violence and the texture of volcanic pyroclasts. In the present study, we performed in situ experiments to investigate the coalescence of two growing bubbles in highly viscous liquids (102 and 1,020 Pa ⋅ s). A new experimental apparatus enables us to directly observe the drainage of the film between growing bubbles in three dimensions. We combined the experimental results and a simple scaling analysis to reveal the dynamics of film drainage in terms of a capillary number depending on the liquid viscosity η, the bubble growth rate , and the surface tension σ. The capillary number represents the interplay between the viscous force arising from bubble growth and the capillary force. At Ca ≪ 1, two adjacent bubbles retain their spherical shapes until the film ruptures, and the capillary forces control the drainage timescale. In contrast, at Ca ≫ 1, bubbles largely flatten and bubble growth itself drives film drainage. We also provide a general formula for the drainage timescale over a wide range of capillary numbers (10−3 < Ca < 101). Our results highlight the importance of bubble growth in the coalescence process. The variations of bubble shape and number density during decompression can be explained by the capillary number.
Toward Next‐Generation Lava Flow Forecasting: Development of a Fast, Physics‐Based Lava Propagation Model
Authors: Hyman David M. R. , Dietterich Hannah R. , Patrick Matthew R. 
Published: October 2022

AbstractDuring effusive volcanic crises, the eruption and propagation of lava flows pose a significant hazard to nearby populations, homes, and infrastructure. Consequently, timely lava flow forecasts are a critical need for volcano observatory and emergency management operations. Previous lava flow modeling tools are typically either too slow to produce timely forecasts, or are fast, but lack critical aspects of lava physics or important forecasting outputs. In particular, the strong thermal stratification present in laminar, high‐Prandtl number flows has generally been neglected. Bulk rheological changes have previously been computed from cell‐averaged temperatures, assuming that the flow is thermally mixed. Here, we detail the development and initial testing of Lava2d, a new two‐dimensional depth‐averaged finite volume model of lava flow propagation over natural terrain which accounts for bulk rheological changes due to thermorheological stratification. We use a novel approach to energy conservation based on tracking cooling and solidifying at the flow base and at the moving flow surface, allowing for the estimation of more realistic vertical thermorheological profiles, while maintaining computational efficiency, producing very timely model runs. We validate our approach with three examples: comparison with theoretical propagation of crust‐dominated lava flows, comparison with a large‐scale molten basalt experiment from the Syracuse University Lava Project, and efficiency testing and comparison with the initial phase of the 1984 Mauna Loa lava flows. Our model is shown to produce rapid, realistic forecasts, making it a good candidate for operationalization in active volcanic regions such as in Hawai'i.
Linkage of Equatorial Ionization Anomaly With the Day‐To‐Day Occurrence of Postsunset Irregularities and Scintillation in Low‐Latitude Region Around 110°E
Authors: Luo Weihua , Li Heng , Xiong Chao , Zhu Zhengping , Yu Xiao , Chang Shanshan 
Published: October 2022

AbstractThe zonal electric field and meridional wind are two major factors to affect the formation of both equatorial ionization anomaly (EIA) and plasma irregularities in equatorial and low‐latitude regions, the correlation between the EIA characteristics and the occurrence of both irregularities and the sequent scintillation is always concerned. In this study, we investigated the relationship between the day‐to‐day occurrence of scintillation based on ground‐based GPS observations at Sanya (18.3°N, 109.6°E; dip lat.: 12.8°N) and Hongkong (22.4°N, 114.2°E; dip lat.: 16.1°N), China, and day‐to‐day variations of EIA inferred from the Gravity Recovery and Climate Experiment observations in equinoctial months (March‐April and September‐October) during high solar activities (2012–2014). The results indicated that EIA strength can be linked with the day‐to‐day occurrence of post‐sunset irregularities and scintillation, and post‐sunset scintillation would be likely to occur as electron density above the EIA trough is low and EIA is strong. There are other key factors to affect the initiation and evolution of irregularities besides zonal electric field and meridional wind, such as seed perturbations or wave‐like structures. The day‐to‐day variations of electron density in EIA regions, EIA strength and EIA asymmetry were not well correlated quantitatively with the scintillation intensity representing by daily S4 maximum in low‐latitude region. These results can help us understand and predict the day‐to‐day variability of irregularities and scintillation in equatorial and low‐latitude regions.
Analog and Numerical Modeling of Rift‐Rift‐Rift Triple Junctions
Authors: Maestrelli D. , Brune S. , Corti G. , Keir D. , Muluneh A. A. , Sani F. 
Published: October 2022

AbstractRift‐Rift‐Rift triple junctions are key features of emergent plate boundary networks during fragmentation of a continent. A key example of such a setting is the Afar triple junction where the African, Arabian and Somalian plates interact. We performed analog and numerical models simulating continental break‐up in a Rift‐Rift‐Rift setting to investigate the resulting structural pattern and evolution. We modified the ratio between plate velocities, and we performed single‐stage (with all plates moving at the same time) and two‐stage (where one plate first moves alone and then all the plates move simultaneously) models. Additionally, the direction of extension was changed to induce orthogonal extension in one of the three rift branches. Our models suggest that differential extension velocities in the rift branches determine the localization of the structural triple junction, which is located closer to the rift branch experiencing slower extension velocities. Furthermore, imposed velocities affect the deformation resulting in end‐member fault patterns. The effect of applying similar velocities in all rift arms is to induce a symmetric fault pattern (generating a Y‐shaped geometry). In contrast, a faster plate generates structures trending orthogonal to dominant velocity vectors, while faults associated with the movement of the slower plates remain subordinate (generating a T‐shaped pattern). Two‐stage models reveal high‐angle faults interacting at the triple junction, confirming that differential extension velocities strongly affect fault patterns. These latter models show large‐scale similarities with fault patterns observed in the Afar triple junction, providing insights into the factors controlling the structural evolution of this area.
PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer
Authors: Nimmakayala Rama Krishna , Ogunleye Ayoola O. , Parte Seema , Krishna Kumar Nivedeta , Raut Pratima , Varadharaj Venkatesh , Perumal Naveen Kumar , Nallasamy Palanisamy , Rauth Sanchita , Cox Jesse L. , Lele Subodh M. , Batra Surinder K. , Ponnusamy Moorthy P. 
Published: October 2022

AbstractAcinar-to-ductal metaplasia (ADM) is a precursor lesion of pancreatic ductal adenocarcinoma (PDAC); however, the regulators of the ADM-mediated PDAC development and its targeting are poorly understood. RNA polymerase II-associated factor 1 (PAF1) maintains cancer stem cells leading to the aggressiveness of PDAC. In this study, we investigated whether PAF1 is required for the YAP1-mediated PDAC development and whether CA3 and verteporfin, small molecule inhibitors of YAP1/TEAD transcriptional activity, diminish pancreatic cancer (PC) cell growth by targeting the PAF1/YAP1 axis. Here, we demonstrated that PAF1 co-expresses and interacts with YAP1 specifically in metaplastic ducts of mouse cerulein- or KrasG12D-induced ADM and human PDAC but not in the normal pancreas. PAF1 knockdown (KD) reduced SOX9 in PC cells, and the PC cells showed elevated PAF1/YAP1 complex recruitment to the promoter of SOX9. The PAF1 KD reduced the 8xTEAD and SOX9 promoter-luciferase reporter activities in the mouse KC (KrasG12D; Pdx-1 Cre) cells and human PC cells, indicating that the PAF1 is required for the YAP1-mediated development of ADM and PC. Moreover, treatment with CA3 or verteporfin reduced the expressions of PAF1, YAP1, TEAD4, and SOX9 and decreased colony formation and stemness in KC and PC cells. CA3 treatment also reduced the viability and proliferation of PC cells and diminished the duct-like structures in KC acinar explants. CA3 or verteporfin treatment decreased the recruitment of the PAF1/YAP1 complex to the SOX9 promoter in PC cells and reduced the 8xTEAD and SOX9 promoter-luciferase reporter activities in KC and PC cells. Overall, PAF1 cooperates with YAP1 during ADM and PC development, and verteporfin and CA3 inhibit ADM and PC cell growth by targeting the PAF1/YAP1/SOX9 axis in vitro and ex vivo models. This study identified a regulatory axis of PDAC initiation and its targeting, paving the way for developing targeted therapeutic strategies for pancreatic cancer patients.
GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils
Authors: Chen Yujie , Lian Ni , Chen Sihan , Xiao Ta , Ke Yangying , Zhang Yiqun , Song Changjun , Yang Yong , Xu Song , Gu Heng , Chen Xu 
Published: October 2022

AbstractGasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role of GSDME in UVB-caused skin damage remains unknown. To explore the role of GSDME in UVB-induced skin inflammation. We compared differences in skin appearance, histological features, keratinocyte death modalities, infiltration of immune cells, and levels of some inflammatory cytokines between Gsdme−/− mice and wild type (WT) mice after UVB exposure. We explored whether keratinocytes contribute to GSDME deficiency-caused aggravation of UVB-induced skin inflammation in GSDME knockdown keratinocyte cultured in vitro and keratinocyte-specific Gsdme conditional knockout mice. We used anti-Ly6G antibody to deplete neutrophils and explore their role in UVB-caused skin damage. Skin damage and neutrophils infiltration were aggravated in UVB-challenged Gsdme−/− mice, compared with UVB-challenged WT mice. Apoptosis and necroptosis, which were initiated together with GSDME-mediated pyroptosis in UVB-challenged WT mice, were not enhanced in UVB-challenged Gsdme−/− mice. Neutrophils activation indicators and its recruiting cytokines were increased in skin tissue of UVB-challenged Gsdme−/− mice. However, GSDME knockdown did not lead to the further increase of mRNA and secretion of TNF-α and IL-6 in UVB-challenged keratinocytes. Skin damage was not aggravated in UVB-challenged Gsdme cKO mice. Neutrophils depletion alleviated UVB-caused skin damage in WT mice and Gsdme−/− mice, and eliminated its aggravation in Gsdme−/− mice. This study demonstrates that GSDME plays a restrictive role in UVB-induced skin damage through inhibiting excessive recruitment and activation of neutrophils in the immune microenvironment in UVB-caused skin inflammation. However, keratinocytes might not contribute to this restrictive function.
RUNDC3A/SNAP25/Akt signaling mediates tumor progression and chemoresistance in gastric neuroendocrine carcinoma
Authors: Lin Ziqi , Kwok Hang Fai 
Published: October 2022

AbstractGastric neuroendocrine carcinoma (GNEC), a heterogeneous group of neuroendocrine neoplasms (NENs) derived from gastric neuroendocrine cells, has been shown to be more aggressive and chemoresistant in gastric cancer, which contributes to the poor prognosis. We analysed transcriptome profiles of tumor/non-tumor tissue from GNEC patients and GNEC cell lines to explore the underlying mechanisms. Our results suggest a critical role for synaptosomal-associated protein 25 kDa (SNAP25) in GNEC. SNAP25 was found to stabilize Akt via modulating its monoubiquitination. We further identified RUN domain containing 3A (RUNDC3A) as an upstream molecule that regulates SNAP25 expression, which is associated with tumor progression and chemoresistance in GNECs. Moreover, these findings were extended into multiple NENs including neuroendocrine carcinomas in the intestinal tract, lungs and pancreas. Identifying the RUNDC3A/SNAP25/Akt axis in NENs may provide a novel insight into the potential therapeutic target for patients with NENs.