bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative Research on English Teaching Model Based on Artificial Intelligence and Wireless Communication
Authors: Wang Yuan , Na Kew Si 
Published: June 2022

It is a network system for teaching English through a wireless communication (WC) premised distance teaching system. This is a process of education that is capable of encouraging students’ concerns to acquire knowledge voluntarily. The paper is designed to develop and implement an online intelligent English training system using artificial intelligence (AI) that helps students improve their English learning efficiency in line with knowledge and personality. The system’s numerous sensor nodes may create a variety of topologies. The gathered information is transmitted over the global system for mobile communication (GSM) network to the user interface. The operator can manage the remote sensor node via the GSM network. Nevertheless, there are certain derivative aspects such as the absence of verbal judgment, the actual evaluation and signaling system, the interactive educational platform teachers and learners need. The paper is based on the above issues. It contains a whole talk-based system where teachers, students, and English teaching can be revised together — AIWC (ET-AIWC) systems are designed to improve and advance the genetic algorithm based on an encoding technique for dynamic parameter adjustment of the iterative process based on these problems. In combination with an AI expert system, suitable learning techniques were created to enable students to double the learning effect by half the amount of work. An online teaching assistant system was designed to monitor, regulate, and engage with students throughout the learning process and a modified scoring system that provides real-time evaluation of student speakers to improve students’ oral competence in English better and more efficiently, achieving 95.2%.
The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer
Authors: Almeda Alison F. , Grimes Susan M. , Lee HoJoon , Greer Stephanie , Shin GiWon , McNamara Madeline , Hooker Anna C. , Arce Maya M. , Kubit Matthew , Schauer Marie C. , Van Hummelen Paul , Ma Cindy , Mills Meredith A. , Huang Robert J. , Hwang Joo Ha , Amieva Manuel R. , Han Summer S. , Ford James M. , Ji Hanlee P. 
Published: June 2022

Abstract

Background:
Gastric cancer is a leading cause of cancer morbidity and mortality. Developing information systems which integrate clinical and genomic data may accelerate discoveries to improve cancer prevention, detection, and treatment. To support translational research in gastric cancer, we developed the Gastric Cancer Registry (GCR), a North American repository of clinical and cancer genomics data.

Methods:
Participants self-enrolled online. Entry criteria into the GCR included the following: (i) diagnosis of gastric cancer, (ii) history of gastric cancer in a first- or second-degree relative, or (iii) known germline mutation in the gene CDH1. Participants provided demographic and clinical information through a detailed survey. Some participants provided specimens of saliva and tumor samples. Tumor samples underwent exome sequencing, whole-genome sequencing, and transcriptome sequencing.

Results:
From 2011 to 2021, 567 individuals registered and returned the clinical questionnaire. For this cohort 65% had a personal history of gastric cancer, 36% reported a family history of gastric cancer, and 14% had a germline CDH1 mutation. 89 patients with gastric cancer provided tumor samples. For the initial study, 41 tumors were sequenced using next-generation sequencing. The data was analyzed for cancer mutations, copy-number variations, gene expression, microbiome, neoantigens, immune infiltrates, and other features. We developed a searchable, web-based interface (the GCR Genome Explorer) to enable researchers’ access to these datasets.

Conclusions:
The GCR is a unique, North American gastric cancer registry which integrates clinical and genomic annotation.

Impact:
Available for researchers through an open access, web-based explorer, the GCR Genome Explorer will accelerate collaborative gastric cancer research across the United States and world.
Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity
Authors: Fletcher Alexander J. , Nash Jennifer , Syed Maaz B.J. , Macaskill Mark G. , Tavares Adriana A.S. , Walker Niki , Salcudean Hannah , Leipsic Jonathon A. , Lim Kelvin H.H. , Madine Jillian , Wallace William , Field Mark , Newby David E. , Bouchareb Rihab , Seidman Michael A. , Akhtar Riaz , Sellers Stephanie L. 
Published: June 2022

Background:
Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic aortopathy, its relationship to disease severity has yet to be established.

Methods:
One hundred one thoracic aortic specimens were collected from 57 patients with thoracic aortopathy and 18 control subjects. Standardized histopathologic scores, immunohistochemistry, and nanoindentation (tissue elastic modulus) were compared with the extent of microcalcification on von Kossa histology and 18F-sodium fluoride autoradiography.

Results:

Microcalcification content was higher in thoracic aortopathy samples with mild (n=28; 6.17 [2.71–10.39];
P
≤0.00010) or moderate histopathologic degeneration (n=30; 3.74 [0.87–11.80];
P
<0.042) compared with control samples (n=18; 0.79 [0.36–1.90]). Alkaline phosphatase (n=26;
P
=0.0019) and OPN (osteopontin; n=26;
P
=0.0045) staining were increased in tissue with early aortopathy. Increasingly severe histopathologic degeneration was related to reduced microcalcification (n=82; Spearman ρ, −0.51;
P
<0.0001)—a process closely linked with elastin loss (n=82; Spearman ρ, −0.43;
P
<0.0001) and lower tissue elastic modulus (n=28; Spearman ρ, 0.43;
P
=0.026).
18
F-sodium fluoride autoradiography demonstrated good correlation with histologically quantified microcalcification (n=66; r=0.76;
P
<0.001) and identified areas of focal weakness in vivo.

Conclusions:

Medial microcalcification is a marker of aortopathy, although progression to severe aortopathy is associated with loss of both elastin fibers and microcalcification.
18
F-sodium fluoride positron emission tomography quantifies medial microcalcification and is a feasible noninvasive imaging modality for identifying aortic wall disruption with major translational promise.
Amyloid-β (Aβ)-Related Cerebral Amyloid Angiopathy Causing Lobar Hemorrhage Decades After Childhood Neurosurgery
Authors: Kellie Jeremy F. , Campbell Bruce C.V. , Watson Rosie , Praeger Adrian J. , Nair Girish , Murugasu Anand , Rowe Christopher C. , Masters Colin L. , Collins Steven , McLean Catriona , Yassi Nawaf 
Published: June 2022

Background:
Recent reports raise the possibility of cerebral amyloid angiopathy (CAA) leading to intracerebral hemorrhage in young adults following childhood neurosurgery, suggesting transmission of amyloid-β (Aβ) through neurosurgical procedures including dura mater grafting. Parenchymal Aβ deposition, and to a lesser extent tau aggregation, similar to that seen in Alzheimer disease, have also been described.

Methods:
We conducted a database review of 634 consecutive intracerebral hemorrhage patients aged <65 years at a tertiary stroke center over 20 years to identify such patients.

Results:
We identified 3 patients aged in their thirties who presented with spontaneous lobar intracerebral hemorrhage, with imaging or neuropathology consistent with CAA, and a history of childhood neurosurgery. Two of these patients had undergone a dural repair using cadaveric dura mater (Lyodura). In addition to CAA, both patients had neuropathologically confirmed parenchymal Aβ and tau deposits, characteristic of Alzheimer disease.

Conclusions:
Our findings support the concept of neurosurgical Aβ transmission but suggest that such cases are rare in standard clinical practice.
Agreement for the Termination of the Intra-EU bit s
Authors: Särkänne Katariina 
Published: June 2022

Abstract
While the agreement for the termination of the intra-European Union (EU) bilateral investment treaties (bit s) is moving the intricate question of intra-EU investment arbitration closer to solution, the retroactive effects of the agreement may prove problematic from the viewpoint of international law. It is argued in the article that the underlying reason for this is the different understandings under the EU law perspective and the international law perspective on whether the intra-EU bit s have been inapplicable in the light of international treaty law. Furthermore, the article discusses the proceedings regarding intra-EU awards in national courts in the aftermath of the termination agreement, concluding that there is notable uncertainty looming over the faith of the awards. Finally, an overview is taken on the termination of the bit s in the Member States, which did not sign the termination agreement, discussing the possible consequences of the opt-out.
Dream, Memory, and Reflection: Transfigurations of Su Shi’s Qiuchi Rock in Song Poetry
Authors: Yang Xiaoshan 
Published: June 2022

Abstract
The present study traces the changing meanings of Su Shi’s Qiuchi rock in Song poetry. As an aesthetic artifact, the rock may be gifted and exchanged through literati social interactions. At a more personal level, the rock reminds Su of a mysterious dream and symbolizes a place of retreat, described as his homeland in Shu, a Daoist grotto heaven, and a utopia that is superior to Peach Blossom Spring. The rock also serves as Su’s most faithful companion in the dark days of his exile to the far south. In the poems of Southern Song poets, who experienced the trauma of the fall of northern China to the Jurchens, the rock turns into a nostalgic object but also prompts acute reflections on petrophilia as a morally and philosophically problematic passion.
Recent Developments in Medieval Chinese Literary Research and Pedagogy: An Interview with Ronald Egan
Authors: Zhang Yue , Egan Ronald 
Published: June 2022

Abstract
In this interview, Professor Egan and I discuss issues related to reception studies, Chinese literary history, translation, and graduate education. The interview begins with the advantages and disadvantages of applying reception studies to premodern Chinese literature and to the works of major writers in particular. We then discuss two recent Chinese literary histories written in English and compare them to mainstream literary history written by Chinese scholars in China in terms of their different audiences, purposes, and uses. As scholars and students consult these histories, this discussion led to the topic of how to teach and how to train graduate students. Egan shares his experience with effective approaches for teaching classical Chinese literature in the American academic setting. In the last section of the interview, he focuses on graduate education, the academic and intellectual preparation that students need before they begin their PhD, what they should pay attention to as students, and their job prospects after they receive their degree.
Guarding the Guards: Education, Corruption, and Nepal’s Commission for the Investigation of Abuse of Authority (CIAA)
Authors: Gellner David N. , Adhikari Krishna P. 
Published: June 2022

Abstract
With development, democratization, and market reforms, corruption has become pervasive in Nepal, especially in areas where government licencing is required. Medical education is a site of considerable political and public contention, because of the nexus that links politicians, educational entrepreneurs, and the licencing of medical colleges. The case of Lokman Singh Karki, the notorious chief of the Commission for the Investigation of Abuse of Authority (ciaa) from 2013 to 2016 is explored, as is that of his nemesis, the campaigner for the reform of medical education, Dr Govinda KC. The ciaa was for a time converted into a prime instrument of corruption instead of being a defence against it. Different scales of reciprocity and differing moral valuations of reciprocity lie at the heart of the fierce moral debates over the rightness or wrongness of Dr KC’s hunger strikes.
30-Day Postoperative Outcomes in Patients With Limited Mobility – A Propensity Score-Matched Comparative Analysis
Authors: Feng Xiaoxi , Blevins Katherine , Tseng Joshua , Sandhu Kulmeet , Cunneen Scott , Burch Miguel 
Published: June 2022

Introduction There is limited data correlating preoperative mobility limitations with clinical outcomes in bariatric patients. This study uses propensity score matching (PSM) to compare 30-day outcomes between patients with preoperative limited mobility (LM) versus patients without (non-LM). Methods Using the 2016-2018 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database, patients undergoing primary laparoscopic sleeve gastrectomy or gastric bypass were identified. Two cohorts were defined using preoperative LM status. To adjust for confounders, 1:1 PSM was performed using 25 preoperative characteristics, and balance was assessed with standardized mean difference. Preoperative patient demographics and postoperative 30-day outcomes were compared in both matched and unmatched cohorts. Results 453,146 patients were identified, of which 6942 (1.47%) were LM and 464,555 were non-LM. 1:1 PSM matched 6624 LM to 6624 non-LM patients with good balance for all covariates. LM had higher rates of unplanned intubation (0.4% vs 0.7%, P < .01), unplanned admission to ICU (1.4% vs 2.5%, P < .01), readmissions (4.1% vs 4.9%, P = .036), unplanned reoperation (1.5% vs 2.0%, P = .02), and 30-day mortality (0.2% vs 0.5%, P = .02). Complications including acute renal failure, intra/postoperative myocardial infarction, venous thrombosis, and pulmonary embolism were not significantly different between the matched groups. Conclusion After adjusting for confounders, patients with preoperative limited mobility have higher rates of intubation, ICU admission, reoperation, readmission, and mortality. Prudent pre-operative candidate selection, counseling, and risk mitigation strategies are needed when a patient with limited mobility status is being considered for bariatric surgery.
Invasive Fungal Sinusitis During Active COVID-19 Infection
Authors: Borrelli Michela , Nasrollahi Tasha , Ulloa Ruben , Raskin Jonathan , Ference Elisabeth , Tang Dennis M. 
Published: June 2022

This case study demonstrates a 58-year-old female who contracted COVID-19 post-vaccination presenting with severe left-sided facial pain, headaches, and dyspnea. A computed tomography was ordered and showed acute sinusitis, and upon bedside endoscopy, the patient was shown to have necrosis of the left-sided middle turbinate with no discoloration, palate necrosis, or facial changes. All samples of the necrotic tissue were reported to be invasive fungal sinusitis. The entire turbinate was resected in the operating room and ethmoid, frontal, and maxillary sinuses were healthy. Chest x-rays post-operatively showed pulmonary effusions and edema although the patient was not stable enough for a lung examination to rule out a pulmonary fungal infection. A bedside endoscopy showed no further necrosis post-operatively although a repeat endoscopy showed duskiness at the lateral attachment of the basal lamella right at the most posterior resection of the middle turbinate. The patient was placed on multiple antifungal agents. The patient remained in hypoxemic respiratory failure and septic shock while on pressors and 2 weeks following this, expired. Post–COVID-19 patients have been shown in the literature to have an increased risk of developing invasive fungal sinusitis (IFS) and all IFS cases during active COVID-19 infection have had a 100% mortality rate.
The utility of the surprise question: A useful tool for identifying patients nearing the last phase of life? A systematic review and meta-analysis
Authors: van Lummel Eline VTJ , Ietswaard Larissa , Zuithoff Nicolaas PA , Tjan Dave HT , van Delden Johannes JM 
Published: June 2022

Background: The surprise question is widely used to identify patients nearing the last phase of life. Potential differences in accuracy between timeframe, patient subgroups and type of healthcare professionals answering the surprise question have been suggested. Recent studies might give new insights. Aim: To determine the accuracy of the surprise question in predicting death, differentiating by timeframe, patient subgroup and by type of healthcare professional. Design: Systematic review and meta-analysis. Data sources: Electronic databases PubMed, Embase, Cochrane Library, Scopus, Web of Science and CINAHL were searched from inception till 22nd January 2021. Studies were eligible if they used the surprise question prospectively and assessed mortality. Sensitivity, specificity, negative predictive value, positive predictive value and c-statistic were calculated. Results: Fifty-nine studies met the inclusion criteria, including 88.268 assessments. The meta-analysis resulted in an estimated sensitivity of 71.4% (95% CI [66.3–76.4]) and specificity of 74.0% (95% CI [69.3–78.6]). The negative predictive value varied from 98.0% (95% CI [97.7–98.3]) to 88.6% (95% CI [87.1–90.0]) with a mortality rate of 5% and 25% respectively. The positive predictive value varied from 12.6% (95% CI [11.0–14.2]) with a mortality rate of 5% to 47.8% (95% CI [44.2–51.3]) with a mortality rate of 25%. Seven studies provided detailed information on different healthcare professionals answering the surprise question. Conclusion: We found overall reasonable test characteristics for the surprise question. Additionally, this study showed notable differences in performance within patient subgroups. However, we did not find an indication of notable differences between timeframe and healthcare professionals.
Development and validation of novel prognostic models based on RNA-binding proteins in breast cancer
Authors: Fan Wei , Ding Jun , Liu Shushu , Zhong Wei 
Published: June 2022

Objectives We aimed to construct novel prognostic models based on RNA-binding proteins (RBPs) in breast cancer (BRCA) and explore their roles in this disease and their effects on tumor-infiltrating immune cells (TIICs). Methods Datasets were downloaded from the Gene Expression Omnibus (GEO) database. Functions and prognostic values of RBPs were systematically investigated using a series of bioinformatics analysis methods. TIICs were assessed using CIBERSORT. Results Overall, 138 differentially expressed RBPs were identified, of which 86 were upregulated and 52 were downregulated. Of these, 13 RBPs were identified as prognosis-related and adopted to construct an overall survival (OS) model, while 12 RBPs were used for the relapse-free survival (RFS) model. High-risk patients had poorer OS and RFS rates than low-risk patients. The results indicate that the OS and RFS models are good prognostic models with reliable predictive abilities. In addition, the proportions of CD8, CD4 naïve, and CD4 memory resting T cells, as well as resting dendritic cells, were significantly different between the low-risk and high-risk groups in the OS model. Conclusions OS and RFS signatures can be used as reliable BRCA prognostic biomarkers. This work will help understand the prognostic roles and functions of RBPs in BRCA.
Portable electronic bronchoscopy for clinical application: a multi-institutional randomized instrument validation study
Authors: Qiu Yuanhua , Feng Ganzhu , Yu Zhen , Wang Limin , Chen Enguo 
Published: June 2022

Objective Electronic bronchoscopy is routinely used for the diagnosis and treatment of lung and bronchial disorders. However, the devices used are normally large and costly. Here, we evaluated the clinical effectiveness of a portable electronic bronchoscope produced by Zhejiang UE Medical Corp., the UE-EB. Methods We conducted a multi-institutional, randomized, single-blind, non-inferiority and parallel-group controlled clinical trial. Participants were randomly assigned 1:1 to the experimental group or control group. The primary indicator was the effectiveness of the device. Safety indicators were assessed from enrollment to 3 days after the operation. Results The UE-EB had good consistency between groups during the procedure, and the effective rate was 100.00% in both groups. The difference value (95% confidence interval) between the two groups was 0.00% (−5.45%, 5.45%), and the lower limit was greater than −10% (negative non-inferiority margin). There was also no difference between the two groups in terms safety indicators. Conclusions The portable electronic bronchoscope described in this study showed reliable effectiveness and safety. This device is worth promoting and applying in clinical practice. Research registry number: ZXLB20200295 (Zhejiang Medical Products Administration, China).
Early outcomes of Sun’s procedure in elderly patients with acute aortic dissection: a single-center retrospective study
Authors: Zhong Liang , Xiong Hongyan , Li Jing , He Yong , Zhou Heping 
Published: June 2022

Objective The effect of patient age on the outcome of Sun’s procedure for acute type A aortic dissection (ATAAD) remains controversial. We retrospectively investigated the early outcomes of Sun’s procedure in elderly patients with ATAAD in our single center. Methods This study involved 106 patients who underwent Sun’s procedure. The patients were divided into the elderly group (≥70 years, n = 17) and younger group (<70 years). Baseline, intraoperative, and postoperative data were compared between the groups. Results The mean age in the elderly and younger groups was 75.7 and 50.7 years, respectively. The type of aortic root operations were not significantly different between the groups. Concomitant surgeries were more frequently performed in the elderly group, but without statistical significance. All intraoperative cardiopulmonary bypass variables as well as the in-hospital and 30-day mortality rates were similar between the groups. The incidences of most postoperative complications were also similar except for a higher incidence of sepsis in the elderly group. Conclusions Emergency performance of Sun’s procedure for patients with ATAAD characterized by dissection and/or entry tear in the aortic arch should not be denied on the basis of advanced age alone. Comparable early in-hospital outcomes can be achieved in elderly patients.