bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Adaptive Hierarchical Gradient Structure‐Based In Situ Sensor with High‐Pressure Resolution
Authors: Luo Zewei , Huang Zepeng , Liu Xingchi , Ye Changqing , Luo Chen , Wang Chaolun , Cai Chunhua , Lv Liangjian , Bi Hengchang , Chu Junhao , Wu Xing , Shen Guozhen 
Published: July 2022

AbstractPressure sensors are a promising design paradigm for wearable devices required to interact gently with the environment. To enable flexible sensors to respond intelligently to the surroundings, microstructures for subtle pressure and force waveform detection are needed. Here, a self‐adaptive pressure sensor is reported in which graphene‐based flakes adhere to the melamine sponge backbones forming hierarchical structures and exhibiting high‐pressure resolution. Under a high preload pressure of 100 kPa, the pressure sensor demonstrates a high‐pressure resolution ability of ≈1‰. The self‐adaptive microstructure change and mechanical behavior are observed simultaneously and dynamically using in situ electron microscopy. The high‐pressure resolution of the pressure sensor enables it to monitor subtle human ballistocardiogram signals, which demonstrates excellent potential in multifarious applications of human motion detection and health monitoring.
One‐Pot Synthesis of Quinazolines via Elemental Sulfur‐Mediated Oxidative Condensation of Nitriles and 2‐(Aminomethyl)anilines
Authors: Tan Yuxing , Jiang Wujiu , Ni Penghui , Fu Yang , Ding Qiuping 
Published: July 2022

AbstractA strategy for the synthesis of quinazolines via elemental sulfur‐mediated oxidative condensation of nitriles and 2‐(aminomethyl)anilines was developed. The reaction was carried out under metal‐/solvent‐free conditions, tolerates a wide range of functional groups to provide the corresponding products in 56%‐91% yield, and can be performed on a gram‐scale. The UV/Vis absorption and fluorescence spectra of several product derivatives were measured to study their photophysical properties.magnified image
Speech and language development and genotype–phenotype correlation in 49 individuals with KAT6A syndrome
Authors: St John Miya , Amor David J. , Morgan Angela T. 
Published: July 2022

AbstractPathogenic KAT6A variants cause syndromic neurodevelopmental disability. “Speech delay” is reported, yet none have examined specific speech and language features of KAT6A syndrome. Here we phenotype the communication profile of individuals with pathogenic KAT6A variants. Medical and communication data were acquired via standardized surveys and telehealth‐assessment. Forty‐nine individuals (25 females; aged 1;5–31;10) were recruited, most with truncating variants (44/49). Intellectual disability/developmental delay (42/45) was common, mostly moderate/severe, alongside concerns about vision (37/48), gastrointestinal function (33/48), and sleep (31/48). One‐third (10/31) had a diagnosis of autism. Seventy‐three percent (36/49) were minimally‐verbal, relying on nonverbal behaviors to communicate. Verbal participants (13/49) displayed complex and co‐occurring speech diagnoses regarding the perception/production of speech sounds, including phonological impairment (i.e., linguistic deficits) and speech apraxia (i.e., motor planning/programming deficits), which significantly impacted intelligibility. Receptive/expressive language and adaptive functioning were also severely impaired. Truncating variants in the last two exons of KAT6A were associated with poorer communication, daily‐living skills, and socialization outcomes. In conclusion, severe communication difficulties are present in KAT6A syndrome, typically on a background of significant intellectual disability, vision, feeding and motor deficits, and autism in some. Most are minimally‐verbal, with apparent contributions from underlying motor deficits and cognitive‐linguistic impairment. Alternative/augmentative communication (AAC) approaches are required for many into adult life. Tailored AAC options should be fostered early, to accommodate the best communication outcomes.
Monogenic focal segmental glomerulosclerosis: A conceptual framework for identification and management of a heterogeneous disease
Authors: Sambharia Meenakshi , Rastogi Prerna , Thomas Christie P. 
Published: July 2022

AbstractFocal segmental glomerulosclerosis (FSGS) is not a disease, rather a pattern of histological injury occurring from a variety of causes. The exact pathogenesis has yet to be fully elucidated but is likely varied based on the type of injury and the primary target of that injury. However, the approach to treatment is often based on the degree of podocyte foot process effacement and clinical presentation without sufficient attention paid to etiology. In this regard, there are many monogenic causes of FSGS with variable presentation from nephrotic syndrome with histological features of primary podocytopathy to more modest degrees of proteinuria with limited evidence of podocyte foot process injury. It is likely that genetic causes are largely underdiagnosed, as the role and the timing of genetic testing in FSGS is not established and genetic counseling, testing options, and interpretation of genotype in the context of phenotype may be outside the scope of practice for both nephrologists and geneticists. Yet most clinicians believe that a genetic diagnosis can lead to targeted therapy, limit the use of high‐dose corticosteroids as a therapeutic trial, and allow the prediction of the natural history and risk for recurrence in the transplanted kidney. In this manuscript, we emphasize that genetic FSGS is not monolithic in its presentation, opine on the importance of genetic testing and provide an algorithmic approach to deployment of genetic testing in a timely fashion when faced with a patient with FSGS.
Bifunctional Metal‐free Heterogeneous Catalyst for the Synthesis of Methanol and Diols from CO2 and Epoxide
Authors: Chatterjee Rupak , Bhattacharjee Sudip , Bhaumik Asim 
Published: July 2022

AbstractCurrently world is facing a serious environmental concern in the steady increase in the CO2 concentration in air and this is directly related to climate change. Thus, successful utilization of CO2 into valuable chemicals is one of our primary goals. Herein, we have successfully fabricated a porous organic polymer PDVTA‐1 via the free radical cross coupling between divinylbenzene and triallyl amine. This porous polymer is found to possess permanent porosity with a very high BET surface area of 915 m2 g−1. Furthermore, upon sulfonation PDVTA‐1 is found to be very active as a bifunctional catalyst with a high BET surface area of 477 m2g‐1 and it efficiently catalyzes the synthesis of methanol and diols from CO2 and respective epoxide under solvent‐free process and relatively milder reaction conditions. In this method 34% yield of methanol and 53% propylene glycol are produced from CO2 and propylene oxide by using considerably mild reducing agent Et3SiH.
Highly Efficient Electrocatalytic Oxygen Evolution Over Atomically Dispersed Synergistic Ni/Co Dual Sites
Authors: Pei Zhihao , Lu Xue Feng , Zhang Huabin , Li Yunxiang , Luan Deyan , Lou Xiong Wen (David) 
Published: July 2022

AbstractSingle‐atom catalysts (SACs) are being pursued as economical electrocatalysts. However, their low active‐site loading, poor interactions, and unclear catalytic mechanism call for significant advances. Herein, atomically dispersed Ni/Co dual sites anchored on nitrogen‐doped carbon (a‐NiCo/NC) hollow prisms are rationally designed and synthesized. Benefiting from the atomically dispersed dual‐metal sites and their synergistic interactions, the obtained a‐NiCo/NC sample exhibits superior electrocatalytic activity and kinetics towards the oxygen evolution reaction. Moreover, density functional theory calculations indicate that the strong synergistic interactions from heteronuclear paired Ni/Co dual sites lead to the optimization of the electronic structure and the reduced reaction energy barrier. This work provides a promising strategy for the synthesis of high‐efficiency atomically dispersed dual‐site SACs in the field of electrochemical energy storage and conversion.
Surface modification of silk fibroin composite bone scaffold with polydopamine coating to enhance mineralization ability and biological activity for bone tissue engineering
Authors: Peng Caixing , Shu Zhan , Zhang Cencen , Chen Xiuhao , Wang Mengting , Fan Lihong 
Published: July 2022

AbstractBone tissue engineering plays an important role in the treatment of bone defects. Finding suitable bone graft substitute scaffolds is still a major challenge. In this study, we combined silk fibroin‐octacalcium phosphate composite with silk fibroin by freeze‐drying technology, and the freeze‐dried scaffolds were further surface‐modified with self‐polymerization by using dopamine. The silk fibroin/octacalcium phosphate/polydopamine composite bone scaffold was successfully constructed. The composition and structure of the scaffolds were examined through Fourier infrared spectroscopy, X‐ray diffraction and scanning electron microscopy. The effects of different concentrations of polydopamine coatings on the porosity, swelling property, hydrophilicity, compressive strength, mineralization ability and biocompatibility of scaffolds were measured. The experimental results showed that the scaffolds had interconnected 3D network structure and polydopamine coating increased the compressive strength of SF scaffolds, delayed the degradation rate of scaffolds and enhanced the apatite deposition rate on the surface of scaffolds. The relative viability of cells increased with the rising of the concentration of coated polydopamine after co‐culture with MC3T3‐E1 cells. The polydopamine coating conferred the scaffolds excellent bioactivity. Therefore, silk fibroin/octacalcium phosphate/polydopamine composite scaffold may provide a new idea for bone tissue engineering.
Co‐assembly behavior of oppositely charged thermoresponsive elastin‐like polypeptide block copolymers
Authors: Choi Jeong‐Wan , Heo Tae‐Young , Choi Heelak , Choi Soo‐Hyung , Won Jong‐In 
Published: July 2022

AbstractThe formation of complex coacervate core micelles (C3Ms) was observed by mixing two oppositely charged elastin‐like polypeptides (ELP)‐based diblock copolymers, each composed of a neutral and a charged moiety. The physical properties of C3Ms as a function of pH, temperature, and salt concentration were analyzed by UV–visible spectrometry, dynamic light scattering (DLS), 1H NMR, and small angle X‐ray scattering (SAXS). In distilled water (or low salt conditions), below the transition temperature (Tt), ELP mixtures induced the C3Ms with a complex coacervate core and a neutral corona; meanwhile, above the Tt, they aggregated by the hydrophobic interaction among the neutral coronas. However, as the salt concentration increased, the induced C3Ms gradually dissociated; while above the critical micellar temperature (CMT) and critical salt concentration (CSC), inverted hydrophobic core micelles surrounded by the charged blocks were created. Based on these results, we demonstrate that the co‐assembly behavior of two oppositely charged diblock ELPs is harnessed by the salt concentration and temperature.
Mobility control capability of a modified chitosan hyperbranched polymer in porous media
Authors: Chen Qingyuan , Ye Zhongbin , Wang Zhouxin , Zhang Shusong , Lai Nanjun 
Published: July 2022

AbstractThe residual resistance factor (RRF) is an important parameter expressing the mobility control capability of the polymer, and it is related to the polymer molecular structure. This study investigated the ability of three polymers with different molecular structures to establish RRF in a one‐dimensional sand pack model at different permeabilities. In addition, the static adsorption capacity of the three polymers on the rock surface was investigated, and the mechanism of the polymer retention in porous media was explored by changing the wettability of the rock surface. Furthermore, the microscopic morphological changes of the polymers before and after passing through the porous media were observed by environmental scanning electron microscopy. Finally, nuclear magnetic resonance core flooding experiments were used to investigate the oil displacement characteristics of the three polymers in the core. T Results show that the ability of the three polymers to establish RRF gradually decreases with the increase in permeability. Still, the modified chitosan hyperbranched polymer (HPDACS) has the best ability to establish RRF in porous media with the largest static adsorption equilibrium amount of 1249 μg/g. Mechanical capture is the dominant mechanism for HPDACS to establish retention in porous media. In addition, HPDACS has a better ability to enhance recovery. It can improve oil recovery by 20.43%, which is higher than that by dendritic polymer HPDA at 16.34% and partially hydrolyzed polyacrylamide at 10.07%. HPDACS can establish a larger resistance in the macropores of the core. Thus, the remaining oil is better driven in the medium and small pores. This finding indicates that HPDACS has excellent potential for oil displacement.
Effect of silica dispersed by special dispersing agents with green strategy on tire rolling resistance and energy consumption
Authors: Zheng Xingfu , Song Shi Kai , Zhou Ziwen , Jiang Xizhou , Sui Yongqiang , Che Mingming , Xu Qi , Wang Yan , Zhao Shuai , Li Lin 
Published: July 2022

AbstractThe state‐of‐art approach to realize the low rolling resistance of green tires is the high addition of SiO2. However, its dispersion capacity and the interface strength with rubber dominant the final properties of green tires. Here, we systematically study amphiphilic polyoxyethylene sorbitan monooleate, oleylamine, sorbitan monooleate, and oleamide to modify SiO2 through simple hydrogen‐bonded self‐assembly in order to replace the traditional silane coupling agent with low modification efficiency, many side reactions and complex reaction process. The results show that the rolling resistance and processing energy loss of the rubber composite prepared by SiO2 modified with polyoxyethylene sorbitan monooleate and oleylamine are significantly reduced, and other physical and mechanical properties (tensile strength, tear strength, and wear resistance) are also significantly improved compared with the silane coupling agent commonly used in green tire tread. Meanwhile, carbon–carbon double bonds belonging to polyoxyethylene sorbitan monooleate and oleylamine can participate in vulcanization of rubber to strongly improve the dispersion ability of SiO2 and the interface interaction between SiO2 and rubber matrix, so as to develop the fuel‐efficient green tire tread with high performance and low rolling resistance.
Porous structure contained polyimide film with enhanced dielectric properties upon high temperature
Authors: Ma Yingyi , He Zian , Liao Ziwei , Han Yuhang , Zhang Junming , Zhu Min 
Published: July 2022

AbstractThe dimensional and property stability after heating is considered to be one of the most important properties for low‐dielectric‐constant materials. Herein, porous structure contained composite PI film with porous PI structure on the surface of a flat PI film was prepared through the simple and low‐cost microemulsion method. The introduction of porous coating can significantly improve the dielectric and water resistance properties of PI film, while maintaining its good mechanical properties. More importantly, the porous structures were well preserved after heating, but with the remove of surfactant layer on the inner surface of the pores, leading to lower dielectric constants with 1.06%–3.50% of reduction and lower dielectric losses less than 0.015 with the maintenance of good water resistance and mechanical properties. Excellent durability of the low dielectric constants and low dielectric losses upon high humidity were also shown for the heated composite PI film. In addition, the morphology and properties of the composite PI film both before and after heating could be controlled through varying the fabrication conditions. These results provide valuable information for the construction of the thermally stable low‐dielectric‐constant material.
Quantitation of navtemadlin in human plasma and brain tissue by liquid chromatography–tandem mass spectrometry
Authors: Kagan Amanda B. , Anders Nicole M. , Hemingway Avelina , Lee Eudocia Q. , Kelly Kevin R. , Lee Hans C. , Xu‐Welliver Meng , Piekarz Richard , Rudek Michelle A. 
Published: July 2022

AbstractNavtemadlin is an orally bioavailable small molecule that blocks the protein–protein interaction between murine double minute 2 protein (MDM2) and the tumor suppressor protein p53, leading to p53‐mediated cell cycle arrest and apoptosis. It is being evaluated in clinical trials for a variety of malignancies, both as a single agent and in combination regimens. A sensitive, robust LC–tandem mass spectrometry (LC–MS/MS) method was developed to quantitate navtemadlin in plasma, and this method was also validated using brain tissue homogenate. Sample preparation involved protein precipitation of plasma or brain tissue homogenate using acetonitrile. Navtemadlin, navtemadlin glucuronide, and the internal standard, D6‐navtemadlin, were separated from microsomal incubation extracts using gradient elution and a ZORBAX XDB C18 column. Analytes were detected using a SCIEX 5500 triple quadrupole mass spectrometer in positive electrospray ionization mode. The assay range of 1–1000 ng/mL was shown to be accurate (96.1–102.0% and 95.7–104%) and precise (coefficient of variation ≤ 10.6% and ≤ 6.6%) in plasma and brain tissue homogenate, respectively. An 8000 ng/mL navtemadlin sample diluted 1:10 (v/v) with plasma was also accurately quantitated. Navtemadlin has been stable in frozen plasma at −70°C for at least 20 months. This validated LC–MS/MS method was applied to determine navtemadlin concentrations in plasma and brain tissue samples from two separate patients receiving 120 mg/day navtemadlin on protocol ABTC1604.
Zn‐Nx Doping in Carbon Nanotubes Boosts Selective CO2 Electroreduction to CO
Authors: Gao Lijun , Bai Silin , Zhang Yating , Hu Chao 
Published: July 2022

AbstractElectroreduction of CO2 to CO is attractive target to store energy from intermittent sources, as it requires the transfer of only two electrons and two protons. Metal‐based catalysts (Au, Ag, Ni, Fe, etc.), especially metal‐ and N‐co‐doped carbon materials have been proven to show high selectivity for CO production. However, for Zn‐based catalysts, the critical active site is still intensely debated. Herein, we synthesize a series of carbon nanotube‐supported Zn‐based catalysts with a tunable ratio of isolated ZnNx sites and Zn‐based nanoparticles. We identify ZnNx moieties anchored on the surface of carbon nanotubes are catalytically highly active for the selective CO2 electroreduction to CO, with the Faradaic efficiency (FE) as high as 97.3 %. In contrast, N‐doped carbon nanotubes (NCNTs) and Zn‐containing nanoparticles supported on NCNTs exhibit inferior selectivity with the CO FEs of 56.7 % and 72.9 %, respectively, suggesting that Zn doping in carbon and the existing forms are of significant importance for improving the ability of Zn‐based catalysts for electrocatalytic reduction of CO2.
Rutile TiO2 Production: Optimization of Microwave Calcination of Metatitanic Acid Using Response Surface Methodology
Authors: Bao Rui , Liu Bingguo , Zhang Ting , Wu Bangjian , Dong Enhua , Yuwen Chao 
Published: July 2022

AbstractRutile TiO2 was prepared by microwave calcination of metatitanic acid. A quadratic regression model for the conversion to rutile TiO2 was developed by response surface methodology (RSM), to investigate the effects of the calcination temperature, the calcination time, the sample mass, and their interactions on the conversion rates. Within the scope of the experiments, only the calcination temperature and time had significant effects on the rutile TiO2 conversion. Under the optimized conditions (866 °C, 61 min, 58 g), the predicted rutile TiO2 conversion was 99.91 %, approaching the actual conversion (99.44 %). Thus, the optimization by RSM of microwave calcination of metatitanic acid for the preparation of rutile TiO2 is a feasible approach to achieving a more efficient TiO2 production process.
Voltammetric Study of Lomefloxacin Transfer at the Interface between Two Immiscible Electrolyte Solutions: Ionic Partition, Photodegradation, and Sensing Applications
Authors: Salman Muhammad , Lee Sang Hyuk , Jeshycka Shinta , Lee Ji Soo , Lee Hye Won , Lee Hye Jin 
Published: July 2022

AbstractThe transfer of ionizable lomefloxacin (LOM) across a polarized interface between two immiscible electrolyte solutions (ITIES) was studied using cyclic and differential pulse voltammetry (DPV). The pH values of water (ionic strength=0.02 M) interfacing with the 1,2‐dichloroethane phase were varied to investigate the transfer behavior of differently charged LOM species, including protonated, neutral, and zwitterionic forms of LOM, namely HLOM+, LOM0, and H+LOM−. An ionic partition diagram for LOM was drawn with DPV response at various pH values, and the distinctive features of LOM were compared to those of fluoroquinolone antibiotics, which have similar pKa values. Physical and thermodynamic properties, including the formal transfer potential, lipophilicity, and Gibbs free energy of transfer of LOM were also evaluated. Furthermore, the photodegradation properties of differently charged LOM species and ophthalmic LOM drop samples (pH 5.0) were investigated after exposure to a UV (λ=365 nm) source. Quantitative analysis of HLOM+ concentrations in buffer and diluted commercial eye drop solutions containing LOM was finally demonstrated using differential pulse stripping voltammetric responses at pH 3.0 and 5.0 involving the transfer of HLOM+ at a polarized microhole‐water/polyvinylchloride‐2‐nitropheyloctylether gel interface.
Statistical inference from finite population samples: A critical review of frequentist and Bayesian approaches
Authors: Beaumont Jean‐François , Haziza David 
Published: July 2022

AbstractIn survey sampling, data are obtained on a subset of a finite population by probability or nonprobability sampling procedures. These data are used to compute point estimates of finite population parameters along with their associated variance estimates and confidence intervals. Methods to conduct inferences and evaluate the properties of sampling and estimation procedures have been the subject of discussion and debate in the second half of the 20th century. In this article, we propose a critical review of three inferential approaches in a finite population context: the design‐based approach, the frequentist model‐based approach, and the Bayesian approach.