bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihypertensive Medication Regimens Used in the Systolic Blood Pressure Intervention Trial
Authors: Derington Catherine G. , Bress Adam P. , Moran Andrew E. , Weintraub William S. , Herrick Jennifer S. , Cushman William C. , Kronish Ian M. , Stults Barry , Shimbo Daichi , Muntner Paul , Greene Tom , Bates Jeffrey T. , Chang Tara I. , Katz Lois Anne , Rehman Shakaib U. , Roumie Christianne L. , Tamariz Leonardo , King Jordan B. 
Published: December 2022

Background:
Describing the antihypertensive medication regimens used in the SPRINT (Systolic Blood Pressure Intervention Trial) would contextualize the standard and intensive systolic blood pressure (SBP) interventions and may inform future implementation efforts to achieve population-wide intensive SBP goals.

Methods:
We included SPRINT participants with complete medication data at the prerandomization and 12-month visits. Regimens were categorized by antihypertensive medication class. Analyses were stratified by treatment group (standard goal SBP <140 mm Hg versus intensive goal SBP <120 mm Hg).

Results:

Among 7860 participants (83.7% of 9361 randomized), the median number of classes used at the prerandomization visit was 2.0 and 2.0 in the standard and intensive groups (
P
=0.559). At 12-months, the median number of classes used was 3.0 and 2.0 in the intensive and standard groups (
P
<0.001). Prerandomization, angiotensin-converting enzyme inhibitor (ACE), or angiotensin-II receptor blocker (ARB) monotherapy was the most common regimen in the intensive and standard groups (12.6% versus 12.2%). At 12-months, ACE/ARB monotherapy was still the most common regimen among standard group participants (14.7%) and was used by 5.3% of intensive group participants. Multidrug regimens used by the intensive and standard participants at 12 months were as follows: an ACE/ARB with thiazide (12.2% and 7.9%); an ACE/ARB with calcium channel blocker (6.2% and 6.8%); an ACE/ARB, thiazide, and calcium channel blocker (11.4% and 4.3%); and an ACE/ARB, thiazide, calcium channel blocker, and beta-blocker (6.5% and 1.2%).

Conclusions:
SPRINT investigators favored combining ACEs or ARBs, thiazide diuretics, and calcium channel blockers to target SBP <120 mm Hg, compared to ACE/ARB monotherapy to target SBP <140 mm Hg.

Registration:

URL:
https://clinicaltrials.gov
; Unique identifier: NCT01206062.
Spatial Patterns and Magnitudes of Agriculturally Pertinent Climate Indicators across Agroecosystems in Türkiye
Authors: Irmak Suat , Kukal Meetpal S. , Topcu Sevilay 
Published: December 2022

Abstract
This research utilized NASA–Prediction of Worldwide Energy Resource (POWER) datasets to quantify and map long-term annual and growing-season mean maximum, minimum, and mean air temperatures (Tmax, Tmin, and Tavg); diurnal temperature range (DTR); growing degree-days (thermal unit) (GDD); seasonal total precipitation; mean daily precipitation; incoming shortwave radiation Rs; relative humidity (RH); wind speed u2; saturation and actual vapor pressures (es and ea); vapor pressure deficit (VPD); grass- and alfalfa-reference evapotranspiration (ETo and ETr); and aridity index (AI) over the nine agricultural zones of Türkiye (Turkey). In addition to the latitudinal influence, the influence of continentality and oceanity effects and physiographic features were evident in the spatial patterns of all climate indicators. Tmin was the most spatially variable indicator at both scales, which can have significant impact on nighttime respiration, potentially reducing agroecosystem productivity. At the annual scale, climate indicators that showed coefficient of variation (CV) greater than 0.20 were GDD, Tavg, VPD, AI, and ea. Growing-season mean indicators with CV > 0.20 were GDD, AI, VPD, total precipitation, mean daily precipitation, and ea. The Rs showed the least spatial variability at both scales. Annual-scale mean CV (0.21) was 7% greater than that the growing season (0.19). To the best of our knowledge, the analyses, information, and resources presented here are the first to quantify agricultural-zone-specific climate indicators during the growing season in Türkiye and are invaluable for decision-making on issues at the intersection of meteorology, agriculture, water resources, and hydrology.
Validation of the Reproducibility of Warm-Season Northeast China Cold Vortices for ERA5 and MERRA-2 Reanalysis
Authors: Gong Ying , Yang Sen , Yin Jinfang , Wang Shu , Pan Xiao , Li Deqin , Yi Xue 
Published: December 2022

Abstract
Reanalysis datasets have been widely used in meteorological research, including studies of Northeast China cold vortices (NCCVs), where these datasets act as effective substitutes for observations. However, to date, no studies have focused on their performance in reproducing NCCVs. To address this knowledge gap, we adopted an automatic three-step identification algorithm (TIA) and used it to detect NCCVs from ERA5 and MERRA-2 reanalysis datasets spanning 39 warm seasons (May–September) during the period from 1980 to 2018. A comparative method was employed for a rough verification of the characteristics of the reproduced NCCVs. Moreover, a dataset derived from 1370 Chinese ground-based observational stations was used to verify the performance of the reanalysis models in reproducing the precipitation and air temperature associated with NCCVs. The results show that the TIA identified the majority of NCCVs, with an accuracy of approximately 90% from ERA5 or MERRA-2. Both reanalysis models can reproduce the characteristics of NCCVs (including location, strength, and duration), and both replicate air temperature better than precipitation. ERA5 and MERRA-2 showed strong consistency in reproducing the central longitude, central latitude, central height, and range of NCCVs, with correlation coefficients of 0.974, 0.972, 0.996, and 0.919, respectively, at the 99.9% significance level. The daily average 2-m temperatures in both reanalysis datasets were in good agreement with observations; however, overestimations of approximately 7°–8°C arose in steep high-altitude regions. In addition, both models tended to overestimate light rain (≤5 mm day−1) by approximately 1.2 mm and underestimate heavy rain (≥20 mm day−1) by over 6.7 mm.
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
Authors: Panetti Silvia , McJannett Nicola , Fultang Livingstone , Booth Sarah , Gneo Luciana , Scarpa Ugo , Smith Charles , Vardon Ashley , Vettore Lisa , Whalley Celina , Pan Yi , Várnai Csilla , Endou Hitoshi , Barlow Jonathan , Tennant Daniel , Beggs Andrew , Mussai Francis , De Santo Carmela 
Published: December 2022

Abstract
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen receptor (CAR) T cells and tumor cells, for the limited availability of amino acids within the environment. We demonstrate that T cells can be re-engineered to express SLC7A5 or SLC7A11 transmembrane amino acid transporters alongside CARs. Transporter modifications increase CAR T-cell proliferation under low tryptophan or cystine conditions with no loss of CAR cytotoxicity or increased exhaustion. Transcriptomic and phenotypic analysis reveals that downstream, SLC7A5/SLC7A11–modified CAR T cells upregulate intracellular arginase expression and activity. In turn, we engineer and phenotype a further generation of CAR T cells that express functional arginase 1/arginase 2 enzymes and have enhanced CAR T-cell proliferation and antitumor activity. Thus, CAR T cells can be adapted to the amino acid metabolic microenvironment of cancer, a hitherto recognized but unaddressed barrier for successful CAR T-cell therapy.
Obstetric and perioperative management of patients with factor XI deficiency: a retrospective observational study
Authors: Handa Shivani , Sterpi Michelle , Sacchi De Camargo Correia Guilherme , Frankel David S. , Beilin Yaakov , Cytryn Lawrence , Hawkins Katherine , Frankel Etta 
Published: December 2022

Abstract
Factor XI (FXI) deficiency is an autosomal inherited, milder bleeding disorder that may predispose to a potential risk of life-threatening bleeding during childbirth or surgery. Unfortunately, data regarding obstetric and perioperative management of this condition are scarce, with limited cases reviewed in the last decade. Therefore, the present study aimed to expand this database and identify factors associated with increased bleeding risk. We performed a retrospective chart review of patients with FXI deficiency who underwent childbirth or other surgical procedures between August 2011 and April 2021 within a single academic health system and identified 198 patients who underwent 252 procedures, including 143 vaginal deliveries, 63 cesarean deliveries, and 46 other surgical procedures. Thirty-three of the 252 procedures resulted in bleeding complications. On multivariable logistic regression analysis, personal history of bleeding was the strongest predictor of perioperative or obstetric bleeding (odds ratio [OR], 5.92; P = .001). Higher FXI levels were correlated with lower odds of bleeding (OR, 0.72 with every 10 U/dL increase in FXI level; P = .05). On receiver operative characteristic analysis, FXI level of &gt;40 U/dL predicted a lower bleeding risk with reasonable specificity (75%) but lacked sensitivity (47%). A family history of bleeding, ethnicity, genotype, preprocedural partial thromboplastin time, and platelet levels were not associated with bleeding risk. There were no cases of epidural or spinal hematoma associated with neuraxial anesthesia. FXI levels remain stable during pregnancy and repeated measurements may not be necessary.
CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression
Authors: Geng Xuerui , Qiu Xiujuan , Gao Jun , Gong Zhifan , Zhou Xiaogang , Liu Chunlei , Luo Haichao 
Published: December 2022

Abstract
Background
Melanoma is a common type of skin cancer, and its incidence is increasing gradually. Exploring melanoma pathogenesis helps to find new treatments.

Objective
We aimed to explore the potential molecular mechanisms by which CREB1 regulates melanoma.

Methods
TransmiR and ALGGEN were used to predict targets of CREB1 in the promoter of miR-495-3p or miR-495-3p and KPNA2, and a dual-luciferase reporter assay was performed to detect binding of CREB1 to these promoters. In addition, binding of CREB1 to the miR-495-3p promoter was confirmed by a ChIP assay. qRT‒PCR was carried out to detect mRNA levels of miR-495-3p, CREB1 and KPNA2. An EdU assay was conducted to detect cell viability. Transwell assays and flow cytometry were performed to assess cell migration and invasion and apoptosis, respectively. Moreover, factors associated with overall survival were analysed by using the Cox proportional hazards model.

Results
Our results show miR-495-3p to be significantly decreased in melanoma. Additionally, miR-495-3p overexpression inhibited melanoma cell viability. CREB1 targeted miR-495-3p, and CREB1 overexpression enhanced melanoma cell viability by inhibiting miR-495-3p transcription. Moreover, miR-495-3p targeted KPNA2, and CREB1 regulated KPNA2 by inhibiting miR-495-3p transcription to enhance melanoma cell viability.

Conclusion
CREB1 regulates KPNA2 by inhibiting miR-495-3p transcription to control melanoma progression. Our results indicate the molecular mechanism by which the CREB1/miR-495-3p/KPNA2 axis regulates melanoma progression.
Basic biochemical and hematological parameters of structural hemoglobin variants in the postpartum women and their respective newborn from Manaus, Amazonas, Brazil
Authors: da Silva Brito Roberta , de Lima Barros Lecita Marreira , Moreira Lilian Wallace , Normando Regina Neves , de Jesus Thiago Bacha , de Souza Gonçalves Marilda , Ramasawmy Rajendranath , de Oliveira Stéfani Ferreira , da Silva Keyla Emanulle Ramos , Fraiji Nelson Abrahim , da Hora Larissa Feitosa , de Abreu Netto Rebeca Linhares , de Moura Neto José Pereira 
Published: December 2022

AbstractThe present study aimed at estimating the prevalence of structural hemoglobinopathies in newborn and describing the hematological and biochemical characteristics between postpartum women (PW) and their respective newborns (NB) at a public maternity hospital in Manaus, Amazonas state, Brazil. In total, 825 NB and 820 PW were included in the study. Hematological and biochemical analysis and screening of structural hemoglobinopathies were performed and compared in groups of individuals (NICU or not; hemoglobin genotypes; gestational age and prenatal). The age of PW ranged from 13 to 44 years old (mean of 23.7 ± 6.6 years), with 45.9% pregnant for the first time and 54.1% multiparous. Reported receiving prenatal care 88% and regarding the type of delivery, 47.7% had delivered by cesarean section. Among the births, 19.4% were born premature and 8.3% were admission to the neonatal intensive care unit (NICU). The male NB represented 53.4% of the total. Sickle cell trait (FAS) was found in 16 (1.94%) and heterozygous for D hemoglobin (FAD) in 6 (0.73%) newborns. A statistically significant values was found between the previous history of miscarriage and increase of Mean corpuscular volume (MCV) (p < .001), Red blood cell distribution width (RDW) (p = .003), total and indirect bilirubin concentration (p < .001) and LDL cholesterol (p = .004). Hemoglobin levels below 13.5 g/dL was found in 66% black newborns, compared with 15% of Afro-Brazilian and 5% of whites. The frequency of structural hemoglobinopathies was higher in African-Brazilian newborn babies (78%) and those who with low birth weight had a higher frequency of NICU (35.7%). Interestingly, underage mothers had a higher frequency of NB with low birth weight and premature birth. Postpartum women who had children carriers of FAS and FAD had a higher frequency of urinary tract infection (65.2%) and moderate anemia (23.8%). This study estimated for the first time the prevalence of structural hemoglobinopathies in NB in Manaus, Amazonas, Brazil. Despite the small prevalence of, we highlight the importance of early diagnosis of hemoglobin variants, contributing to the improvement of the quality of life of PW and your NB, reinforce the need to implement educational and prevention programs to raise awareness among the population and in order to counsel parents regarding the probability of having a child with abnormal hemoglobins homozygous as HbSS or HbCC.
Association of distance between hospitals and volume of shared admissions
Authors: Turbow Sara D. , Uppal Teg , Chang Howard H. , Ali Mohammed K. 
Published: December 2022

Abstract
Background
To assess whether decreasing distance between hospitals was associated with the number of shared patients (patients with an admission to one hospital and a readmission to another).

Methods
Data were from the Healthcare Cost and Utilization Project’s State Inpatient Databases (Florida, Georgia, Maryland, Utah [2017], New York, Vermont [2016]) and the American Hospital Association Annual Survey (2016 & 2017). This was a cross-sectional analysis of patients who had an index admission and subsequent readmission at different hospitals within the same year. We used unadjusted and adjusted linear regression to evaluate the association between the number of shared patients and the distance between admission-readmission hospital pairs.

Results
There were 691 hospitals in the sample (247 in Florida, 151 in Georgia, 50 in Maryland, 172 in New York, 58 in Utah, and 13 in Vermont), accounting for a total of 596,772 admission-readmission pairs. 32.6% of the admission-readmission pairs were shared between two hospitals. On average, a one-mile decrease in distance between two hospitals was associated with of 3.05 (95% CI, 3.02, 3.07) more shared admissions. However, variability between states was wide, with Utah having 0.37 (95% CI 0.35, 0.39) more shared admissions between hospitals per one-mile shorter distance, and Maryland having 4.98 (95% CI 4.87, 5.08) more.

Conclusions
We found that proximity between hospitals is associated with higher volumes of shared admissions.
Reactivation of occult hepatitis B virus infection in a renal transplant recipient
Authors: Jiang Lili , Wang Huiqi , Huang Yaping , Liang Hanying , Wang Xiaodong , Fan Jun 
Published: December 2022

AbstractWe report a case of hepatitis B virus (HBV) reactivation in a renal transplant recipient. Reactivation manifested as an occult infection with detectable HBV-DNA and negativity for hepatitis B surface antigen (HBsAg). The anti-HBs antibody titre was above the protective threshold and continued to rise, to 951.36 mIU/ml, after HBV reactivation. Sequencing revealed multiple vaccine- and diagnostic-escape mutations in the major hydrophilic region of HBsAg. This case demonstrates both reactivation of an HBV escape mutant in a vaccinated patient and host immunity after virus mutation.
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies
Authors: Liu Guojun , Ladrón-de-Guevara Antonio , Izhiman Yara , Nedergaard Maiken , Du Ting 
Published: December 2022

AbstractCerebrospinal fluid (CSF) is an essential and critical component of the central nervous system (CNS). According to the concept of the “third circulation” originally proposed by Cushing, CSF is mainly produced by the choroid plexus and subsequently leaves the cerebral ventricles via the foramen of Magendie and Luschka. CSF then fills the subarachnoid space from whence it disperses to all parts of the CNS, including the forebrain and spinal cord. CSF provides buoyancy to the submerged brain, thus protecting it against mechanical injury. CSF is also transported via the glymphatic pathway to reach deep interstitial brain regions along perivascular channels; this CSF clearance pathway promotes transport of energy metabolites and signaling molecules, and the clearance of metabolic waste. In particular, CSF is now intensively studied as a carrier for the removal of proteins implicated in neurodegeneration, such as amyloid-β and tau. Despite this key function of CSF, there is little information about its production rate, the factors controlling CSF production, and the impact of diseases on CSF flux. Therefore, we consider it to be a matter of paramount importance to quantify better the rate of CSF production, thereby obtaining a better understanding of CSF dynamics. To this end, we now review the existing methods developed to measure CSF production, including invasive, noninvasive, direct, and indirect methods, and MRI-based techniques. Depending on the methodology, estimates of CSF production rates in a given species can extend over a ten-fold range. Throughout this review, we interrogate the technical details of CSF measurement methods and discuss the consequences of minor experimental modifications on estimates of production rate. Our aim is to highlight the gaps in our knowledge and inspire the development of more accurate, reproducible, and less invasive techniques for quantitation of CSF production.
CropPainter: an effective and precise tool for trait-to-image crop visualization based on generative adversarial networks
Authors: Duan Lingfeng , Wang Zhihao , Chen Hongfei , Fu Jinyang , Wei Hanzhi , Geng Zedong , Yang Wanneng 
Published: December 2022

AbstractBackgroundVirtual plants can simulate the plant growth and development process through computer modeling, which assists in revealing plant growth and development patterns. Virtual plant visualization technology is a core part of virtual plant research. The major limitation of the existing plant growth visualization models is that the produced virtual plants are not realistic and cannot clearly reflect plant color, morphology and texture information.ResultsThis study proposed a novel trait-to-image crop visualization tool named CropPainter, which introduces a generative adversarial network to generate virtual crop images corresponding to the given phenotypic information. CropPainter was first tested for virtual rice panicle generation as an example of virtual crop generation at the organ level. Subsequently, CropPainter was extended for visualizing crop plants (at the plant level), including rice, maize and cotton plants. The tests showed that the virtual crops produced by CropPainter are very realistic and highly consistent with the input phenotypic traits. The codes, datasets and CropPainter visualization software are available online.ConclusionIn conclusion, our method provides a completely novel idea for crop visualization and may serve as a tool for virtual crops, which can assist in plant growth and development research.
Risk factors for deep surgical site infection following surgically treated peri-ankle fractures: a case–control study based on propensity score matching
Authors: Zhao Haitao , Meng Jinghong , Sun Tao , Wan Zihan , Qin Shiji , Zhang Fengqi , Hou Zhiyong 
Published: December 2022

Abstract
Aims
This study aims to identify the risk factors for deep surgical site infection (DSSI) following surgically treated peri-ankle fractures.

Methods
We performed a retrospective case–control study using the propensity score matching (PSM) method in 1:2 ratio, based on the 6 baseline variables, including age, gender, living area, insurance type, fracture location and surgical date. Data on patients who underwent surgical treatment of peri-ankle fractures were collected by inquiring their hospitalization medical records and operative records, as well as the laboratory reports. Conditional logistic regression analysis was performed to identify the risk factors for DSSI.

Results
A total of 2147 patients were eligibly included and 74 had a DSSI, indicating an incidence rate of 3.4%. After PSM, 70 cases of DSSI and 140 controls without DSSI were matched, constituting the study cohort. The univariate analyses showed significant differences between groups in terms of history of any surgery, time to operation, surgical wound classification, smoking, alcohol drinking, RBC count, hemoglobin concentration and hematocrit (%). The conditional logistic regression analysis showed time to operation of < 4 or > 9 (vs 4–9 days); unclean wound, current smoking, high-energy injury mechanism and lower hematocrit were independent risk factors for DSSI.

Conclusions
Timely modification of smoking and hematocrit (%), and limiting operation within a rational time frame for an optimized soft tissue condition, may provide potential clinical benefits for SSI prevention.