bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Toxocara species larvae in four Iranian free-range broiler farms
Authors: Shokri Elham , Haniloo Ali , Zibaei Mohammad , Pezeshki Ali , Mansori Kamyar , Taira Kensuke 
Published: September 2022

Abstract
Background
The epidemiology of Toxocara canis and Toxocara cati in food animals, associated products, and their zoonotic potential are poorly understood. A cross sectional study was designed to ascertain the prevalence of Toxocara spp. larvae from free-range broiler chickens of traditional farms using conventional techniques and molecular method. Eight-hundred tissue samples including liver, gizzard, lungs and heart were collected from 200 chickens belongs to various zones of Zanjan Province, Iran and were processed by conventional and molecular techniques.
Results
Out of 800 chicken tissues, 49 samples (6.1%) were found positive for the nematode larvae. Polymerase chain reaction for the species-specific identification of the Toxocara larvae was performed. The findings showed 10.5% of chickens were infected with Toxocara spp. so that 12 samples were positive for Toxocara canis and 9 samples for Toxocara cati.
Conclusion
Considering the significant contamination of free-range broiler chickens with Toxocara larvae, consumption of the chicken's meat and viscera, especially liver and gizzards, can play an important role in transmission of the infection to humans. Prevention and control measures focused on regular deworming of dogs and cats, enhancing public awareness of Toxocara infection are recommended.
IL8 associated with M2 macrophage infiltration as a prognostic biomarker differentiates WHO grade III and grade IV gliomas
Authors: Lin Jang-Chun , Lee Cheng-Chin , Chang Yu-Jia , Lee Ai-Wei , Huang Chien-Yu , Liu Wei-Hsiu 
Published: September 2022

Abstract
Malignant glioma can be divided into grade III (Gr. III) and grade IV (Gr. IV). Gr. III glioma patients have significantly better overall survival (OS) than those with Gr. IV glioma, also known as glioblastoma multiforme (GBM). We explored differentially expressed genes (DEGs) from the GSE4290 and GSE109857 datasets between Gr. III and Gr. IV gliomas. Six candidate prognostic genes for GBM were determined from survival analysis of data obtained from The Cancer Genome Atlas (TCGA), and the results were validated via assessments of the OS of Gr. III glioma and GBM patients using data obtained from the Chinese Glioma Genome Atlas (CGGA). Then, the expression levels of CXCL8, also named IL8, had a significant relationship with progression-free survival (PFS) in Gr. IV patients (P = 0.028), and had no effect in Gr. III glioma patients (P = 0.522). Furthermore, the receiver operating characteristic (ROC) curve revealed the critical role of IL8 with an accuracy value of 0.899 for discriminating Gr. IV from Gr. III in TCGA and 0.644 in CGGA. Macrophage (P < 0.001) and neutrophil (P < 0.001) levels were highly related to IL8 levels, especially for M2 macrophage markers. All M2 markers increased the correlative efficiency from primary GBM to the recurrence group. IL8 in GBM has a significant effect on disease prognosis and tumor immunity. IL8-associated M2 macrophage infiltration could be a prognostic biomarker used to classify GBM and Gr. III gliomas.
Identification of groundwater potential zones using Analytical hierarchy process (AHP) and GIS techniques in Srivaikundam region, Thoothukudi district, South India
Authors: S Richard Abishek. , A Antony Ravindran. , J Vinoth Kingston. , Promilton Antony Alosanai , SK Aswin , R Abinaya 
Published: September 2022

Abstract
In this study, an effort has been made to locate the subsurface basin for groundwater storage and to identify the suitable destination for the sustainable domestic, agricultural, and drinking needs to demarcate groundwater potential zones (GWPZ) for Srivaikundam region in Thoothukudi district, Tamil Nadu, India, using remote sensing and geographical information system (GIS) with analytical hierarchy process (AHP). According to their respective importance for groundwater occurrence, Saaty's scale was appropriately weighted to give the thematic layers and their attributes. The selected thematic maps were then merged using the weighted linear combination method to produce the final groundwater potential zone map after the layers' assigned weights and their features had been standardized using the Analytic Hierarchy Process (AHP) and eigenvector approach. Based on Saaty's 9-point scale, each criterion or factor was given the proper weight, and the weights were then normalized using the analytic hierarchy approach (AHP). To create the groundwater potential prediction map for the research area, the method was incorporated into the GIS environment. They are eight thematic layers are integrated into the GIS platform using weighted index overlay analysis. Groundwater conditions have been used to define GIS analysis criteria, and each information layer has been assigned an appropriate rank and weightage. Finally, groundwater recharge zones have been selected and classified into low, medium, and high based on cumulative weighted value.
Consciousness alteration in focal epilepsy is related to loss of signal complexity and information processing
Authors: Youssef Nada El , Jegou Aude , Makhalova Julia , Naccache Lionel , Bénar Christian , Bartolomei Fabrice 
Published: September 2022

Abstract
Alteration of awareness is a main feature of focal epileptic seizures. In this work, we studied how the information contained in EEG signals was modified during temporal lobe seizures with altered awareness by using permutation entropy (PE) as a measure of the complexity of the signal. PE estimation was performed in thirty-six seizures of sixteen patients with temporal lobe epilepsy who underwent SEEG recordings. We tested whether altered awareness (based on the Consciousness Seizure Score) was correlated with a loss of signal complexity. We estimated global changes in PE as well as regional changes to gain insight into the mechanisms associated with awareness impairment. Our results reveal a positive correlation between the decrease of entropy and the consciousness score as well as the existence of a threshold on entropy that could discriminate seizures with no alteration of awareness from seizures with profound alteration of awareness. The loss of signal complexity was diffuse, extending bilaterally and to the associative cortices, in patients with profound alteration of awareness and limited to the temporal mesial structures in patients with no alteration of awareness. Thus PE is a promising tool to discriminate between the different subgroups of awareness alteration in TLE.
Indirect comparison of survival data based on the Shiny method: the role of control groups in the assessment of heterogeneity
Authors: messori andrea 
Published: September 2022

Abstract
Objective: New techniques have recently been developed to reconstruct patient-level data from Kaplan-Meier curves. Based on these “reconstructed patients”, indirect comparisons can be made to rank the effectiveness of the main treatments available. In these studies, the assessment of heterogeneity is a crucial phase. Our objective was to set up an approach to evaluate heterogeneity when reconstructed patients represent the clinical material. Results: Two data sets are analyzed: the first regards treatments for triple-negative breast cancer (3 trials, 3 treatments), while the second focuses on nonmetastatic prostate cancer (3 trials, 3 treatments and placebo). Heterogeneity has been quantified according to the likelihood ratio test. In the first case, a significant degree of heterogeneity is found (likelihood ratio test, 12.94; df, 1; p=0.0003); consequently, the results of indirect comparisons risk being misleading and therefore require a quite complex interpretation. By contrast, in the second case, the lack of heterogeneity (likelihood ratio test, 1.17; df 2, p=0.60) suggests that the results of indirect comparisons are reliable. Further research is needed to define the most appropriate cut-off in the likelihood ratio test to identify cases where heterogeneity has a relevant impact.
Numerical simulation and experimental validation of thrombolytic therapy for normal patient and venous isomer
Authors: Lin Boyuan , Zhang Xianglei , Xu Jiangping , Ni Haoqi , Lv Xinhuang 
Published: September 2022

Abstract
Thrombus is an extremely dangerous factor in the human body that can block the blood vessel. Once thrombus happens in venous of lower limbs, local blood flow is impeded. This leads to varicosity and even pulmonary embolism. In recent years, venous thromboembolism has frequently occurred in a variety of people, and there is no effective treatment for patients with different venous structures. For the patients with venous isomer with venous valve insufficiency, we establish a coupled computational model to simulate the process of thrombolysis with multi-dose treatment schemes by considering the blood as non-Newtonian fluid. And build corresponding in vitro experimental platform for verifying the performance of the developed mathematical model. Then, the effects of different fluid models, valve structures and drug doses on thrombolysis are comprehensively studied through numerical and experimental observations. Comparing with the experimental results, the relative error of blood boosting index (BBI) obtained from non-Newtonian fluid model is 11% times smaller than Newtonian fluid. In addition, the BBI from venous isomer is 13 times stronger than normal patient while the valve displacement is 5 times smaller. As consequence, low eddy current and strong molecular diffusion near the thrombus in case of isomer promote thrombolysis rate up to 18%. Furthermore, the 80 uM dosage of thrombolytic drugs gets the maximum thrombus dissolution rate 18% while the scheme of 50 uM doses obtains a thrombolysis rate of 14% in case of venous isomer. Under the two administration schemes for isomer patients, the rates from experiments are around 19.1% and 14.9%, respectively. It suggests that the proposed computational model and the designed experiment platform can potentially help different patients with venous thromboembolism to carry out clinical medication prediction.
New Basement Structural Division Map from Analyzing Magnetic Data of Iraq Southern Desert Using Phase Preserving Dynamic Range Compression Technique
Authors: Al-Bahadily Hayder Adnan , Al-Rahim Ali Maki 
Published: September 2022

Abstract
The Iraq Southern Desert (SD) lies in southwest Iraq and tectonically occupies a position on the stable part of the Arabian Platform. The area is characterized by a considerable thickness of Phanerozoic sedimentary sequences, generally non-magnetic, that overlie a Precambrian and reworked Proterozoic basement. The magnetic field, therefore, generally represents the responses of basement rocks. Several qualitative approaches are used for data enhancement of the potential field (gravity and magnetic) allowing for better qualitative interpretation. The present work aims to analyze the magnetic and gravity datasets of the SD and interpret them in terms of structures in the postulated basement and the sedimentary cover. In the present study, the Phase Preserving Dynamic Range Compression technique, which produces a set of dynamic range compressed images at different scales, is utilized to analyze gravity and magnetic datasets of the (SD). A free-download MATLAB code designed for this purpose is used to perform the required analyses. Large scale (long wavelengths) magnetic image, usually reflects deep sources, offers a possibility of structural interpretation of the Proterozoic basement into three blocks and sub-blocks; northwestern block, central block, and southeastern block. The blocks are separated by basement structural lows or grabens that are inferred from depth to basement maps. A small-scale wavelength image usually reflects magnetic sources at shallow basement depth, and displays different magnetic features mostly make up NE-SW lineaments. Analysis of gravity data at large- and small scales show gravity lows and lineament structures within the basement and the sedimentary cover, respectively.
Peripheral oxytocin levels are linked to hypothalamic gray matter volume in autistic adults: a cross-sectional study
Authors: Haaf Raoul , Brandi Marie-Luise , Albantakis Laura , Lahnakoski Juha M. , Henco Lara , Schilbach Leonhard 
Published: September 2022

Abstract
Background
Oxytocin (OXT) is known to modulate social behavior and cognition and has, thus, been expected to be a potential therapeutic agent for individuals with autism spectrum disorder (ASD). However, the underlying neurobiology is far from clear. For instance, relatively little is known about the association between OXT levels and brain structural differences in autistic people. An accumulating body of evidence indicates the hypothalamus to be of particular importance in this regard.
Methods
Here we used region of interest (ROI)- based voxel-based morphometry (VBM) approach to investigate hypothalamic gray matter volume (GMV) in autistic and non-autistic adults. T1-weighted MRI images were obtained from autistic adults without intellectual impairment (n = 29, age 36.03 ± 11.0) and matched non-autistic controls (n = 27, age 30.96 ± 11.2). Peripheral plasma OXT levels and the autism quotient for autistic traits were used for correlation analyses.
Results
GMV of the hypothalamus did not differ between groups. However, the groups showed significant differences in the link between hypothalamic GMV with peripheral OXT levels, such that a positive correlation was found for the ASD group. In addition, hypothalamic GMV showed a positive correlation with autistic traits in the ASD group, while no such correlation was observed in the comparison group.
Limitations
: The relatively small sample size and the wide age range of the participants warrant caution when interpreting the results. Results could be confounded by the use of various psychiatric medications among our autistic participants. At the same time, this adequately represents the adult autistic population in terms of a naturalistic study design.
Conclusion
The results provide new evidence for a potentially important role of the HTH in ASD and its relationship to the OXT system, but also point towards the importance of interindividual differences.
Ground state quantum vortex proton model
Authors: Verrall Steven Charles , Atkins Micah , Kaminsky Andrew , Friederick Emily , Otto Andrew , Verrall Kelly Susan 
Published: September 2022

Abstract
A novel photon-based proton model is developed. A proton’s ground state is assumed to be coherent to the degree that all of its mass-energy precipitates into a single uncharged spherical structure. A quantum vortex, initiated by the strong nuclear force, but sustained in the proton's ground state by the circular Unruh effect and a spherical Rindler horizon, is proposed to confine the proton's mass-energy in its ground state. A direct connection between the circular Unruh effect, the zitterbewegung effect, spin, and general relativity is proposed. Such a structure acts as an uncharged zitterbewegung fermion, and may explain neutrino mass. A ground-state proton's central zitterbewegung fermion is assumed to be surrounded by a halo of charge shells of both signs. Virtual photon standing waves are assumed to synchronize the inner shell with the central zitterbewegung fermion. The charge shells are proposed to be associated with isospin and proton g-factor. There are only two model inputs—proton mass and quantized electronic charge—and just one adjustable parameter. The adjustable parameter, reduced only by about 0.4% from an initial estimate, provides the proton’s experimentally determined magnetic moment to arbitrary precision. The resulting modeled proton charge radius agrees very well with the 2018 CODATA value. Magnetic moment and charge radius are calculated algebraically in a manner easily understood by undergraduate physics students. This proposed ground-state proton model could be falsified by future experimental proton charge radius estimates, and could be considered a low-energy approximation to a full quantum chromodynamical proton model.
Water Irradiation Devoid Pulses Enhance the Sensitivity of 1H, 1H Nuclear Overhauser Effects
Authors: Subrahmanian Manu Veliparambil , Olivieri Cristina , Veglia Gianluigi 
Published: September 2022

Abstract
The nuclear Overhauser effect (NOE) is one of NMR spectroscopy's most important and versatile parameters. NOE is routinely utilized to determine the structures of medium-to-large size biomolecules and characterize protein-protein, protein-RNA, protein-DNA, and protein-ligand interactions in aqueous solutions. Typical [1H,1H] NOESY pulse sequences incorporate water suppression schemes to reduce the water signal that dominates 1H-detected spectra and minimize NOE intensity losses due to unwanted polarization exchange between water and labile protons. However, at high- and ultra-high magnetic fields, the excitation of the water signal during the execution of the NOESY pulse sequences may cause significant attenuation of NOE cross-peak intensities. Using an evolutionary algorithm coupled with artificial intelligence, we recently designed high-fidelity pulses [Water irrAdiation DEvoid (WADE) pulses] that elude water excitation and irradiate broader bandwidths relative to commonly used pulses. Here, we demonstrate that WADE pulses, implemented into the 2D [1H,1H] NOESY experiments, increase the intensity of the NOE cross-peaks for labile and, to a lesser extent, non-exchangeable protons. We applied the new 2D [1H,1H] WADE-NOESY pulse sequence to two well-folded, medium-size proteins, i.e., the K48C mutant of ubiquitin and the Raf kinase inhibitor protein (RKIP). We observed a net increase of the NOE intensities varying from 30 to 170% compared to the commonly used NOESY experiments. The new WADE pulses can be easily engineered into 2D and 3D homo- and hetero-nuclear NOESY pulse sequences to boost their sensitivity.
Thermodynamic properties of asymmetric semiconductor quantum wire under the magnetic field
Authors: Donfack B. , Fotuea A. J. 
Published: September 2022

Abstract
In the present paper, we investigate the effect of polaron on the thermodynamic properties of an asymmetric semiconductor quantum wire under magnetic field. We used the Grand canonical ensemble approach to determine the thermodynamic properties such as: entropy, heat capacity and free energy and some magnetic properties as magnetization and magnetic susceptibility. We have shown that the effect of confinement potential and the application of an external magnetic field increase the energy in the asymmetric quantum wire, for the lowest values of the magnetic field, entropy and heat capacity increase with temperature after their saturation for the same value of the magnetic field they become independent of temperature. It was also found at high values of the temperature the magnetic susceptibility becomes independent of the magnetic field. It has been found that for a magnetic field almost equal to 1 or 1.2 T the entropy as well as the heat capacity reaches their saturation then become independent of the temperature. The diamagnetic aspect of our system allows to extend its scope both in electronics (manufacturing of transistors, energy storage structures, etc.), in industry (the realization of magnetic levitation trains) in medicine (magnetic resonance imaging MRI).
Stereoelectroencephalographic Language and Memory Mapping Complements Traditional Methodologies Used to Evaluate Epilepsy Surgery Candidacy
Authors: Bearden Donald J. , Ehrenberg Andrew , Selawski Robyn , Ono Kim E. , Drane Daniel L. , Pedersen Nigel P. , Cernokova Ivana , Marcus David J. , Luongo-Zink Christopher , Chern Joshua J. , Oliver Corinne , Ganote Jennifer , Al-Ramadhani Ruba , Bhalla Sonam , Gedela Satyanarayana , Zhang Guojun , Kheder Ammar 
Published: September 2022

Abstract
Intracranial electroencephalography is frequently used to study patients with drug-resistant epilepsy and offers a unique opportunity to study human cognition. Its utility can be extended to better understand functional neuroanatomical profiles of patients and guide a tailored, minimally invasive surgical approach. We present prospective data on a 20-year-old patient with drug-resistant left temporal lobe epilepsy who underwent stereoelectroencephalography (SEEG) as a part of epilepsy surgical workup. Given obscurity regarding hemispheric dominance of language and memory, the patient’s workup included functional MRI, Wada procedure, and electrocortical stimulation and mapping of high frequency activity and phase amplitude coupling using SEEG to characterize his anatomofunctional profile. We describe the complementary use of these methods to inform surgical decision-making and functional prognostication. Data from mapping of high frequency activity and phase amplitude coupling, as a relatively new technique, is correlated with results from other procedures to advocate for increasing their utility in surgical planning.
N6-methyladenosine (m 6 A) IGF2BP1 regulates high glucose-induced vascular endothelial cells apoptosis via targeting HMGB1
Authors: Liang Anru , Liu Jianyu , Wei Yanlin , Liao Yuan , Wu Xiaofang , Ruan Jiang , Li Junjun 
Published: September 2022

Abstract
In diabetes mellitus pathophysiology, high glucose (HG)-induced vascular endothelial dysfunction is associated with the progress of diabetes vascular complications. Besides, N6-methyladenosine (m6A) has been reported to participate in the vascular biological characteristic. Nevertheless, the underlying mechanisms of high glucose (HG)-related m6A regulation on vascular endothelial cells are still not entirely clear. The proliferation and apoptosis was detected using EdU assay and flow cytometry. The m6A modified level was identified by m6A quantification analysis and MeRIP-PCR. The molecular interaction within IGF2BP1 and HMGB1 was determined by RIP-PCR. Results indicated that m6A reader insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) up-regulated in HG-administrated Human umbilical vascular endothelium cells (HUVECs) as compared to normal glucose group. Functionally, results indicated that IGF2BP1 knockdown recovered the proliferation of HUVECs inhibited by HG-administration. Besides, IGF2BP1 knockdown reduced the apoptosis triggered by HG-administration. Mechanistically, IGF2BP1 interacts with HMGB1 mRNA and stabilized its expression of m6A-modified RNA. Therefore, these findings provide compelling evidence demonstrating that m6A reader IGF2BP1 contributes to the proliferation and apoptosis of vascular endothelial cells in hyperglycaemia, serving as a target for the development of diabetic angiopathy therapeutics.