bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ trust in the Indian healthcare system and its impact on the intention to use artificial intelligence-based healthcare chatbots
Authors: Chellasamy Aarthy , N. Elangovan , Nagarathinam Aishwarya , Rangasamy Sangeetha 
Published: January 2025

Purpose
Indian patients have different medicine systems available at the service that alter their healthseeking behaviour (HSB). This study aims to examine the beliefs and behaviour of patients in India towards the healthcare system and how it affects their intention to use healthcare chatbots.

Design/methodology/approach
A survey instrument was developed from standard scales and validated by experts. The data was collected from 397 respondents in an urban area and tested using a structural equation model in SAS JMP software.

Findings
The study found that awareness and perception of chatbots and distrust on doctors and health systems impact trust in a chatbot. The results show that trust in chatbots influences the intention to use chatbots. The belief in alternative medicine systems and HSB also influence the intention to use chatbots. The study findings also imply that health-care chatbots should cater to HSB and the belief in alternative medicine.

Research limitations/implications
The study was conducted only among the urban population because services based on technology are more available in metro cities. Bengaluru is considered the representative population of urban India.

Practical implications
The level of disruption that chatbots can provide to the healthcare system makes this study significant. The study findings will help to manage the factors that can enable chatbot inclusivity, as the current system is inaccessible to many patients.

Originality/value
This paper addresses an identified need to study patients’ trust in the Indian healthcare system and their intention to use chatbots. The level of disruptions these chatbots can cause in the health-care system is undeniable and patients’ trust in these chatbots will eventually transform the health-care sector.
Exploring linkages between social diversity, management control, and team performance: an integrative literature review
Authors: Vasquez-Peñaloza Lisseth , Sánchez-Expósito Maria Jesus , Gomez-Ruiz Laura 
Published: January 2025

Purpose
This study aims to explore the influence of management control on the performance of teams with surface levels of social diversity.

Design/methodology/approach
Under the categorization-elaboration model perspective, an integrative literature review was conducted. Selecting articles published in the Scopus and Web of Science databases until 2023 and with the terms about gender diversity, age diversity, racial diversity and team performance, obtaining 122 documents. Results were analyzed in a matrix under the criteria of social diversity as a principal variable and examined the effects on team performance. Subsequently, it is synthesized according to the social diversity dimension and then integrated into an analysis with conceptual perspectives from management control systems.

Findings
The main negative effects of surface-level social diversity on team performance arise from stereotypical perceptions and social biases about differences in gender, age and race, affecting team members’ interactions. This scenario is related to the causes of the need for management control in the absence of direction, motivation problems and personal limitations, so control systems associated with possible solutions to improve group performance are proposed.

Originality/value
To the authors’ knowledge, this work opens the discussion on the influence of management control on the performance of teams with social diversity. Demographic changes require new perspectives for team management, from management control providing a way to guide socially diverse team behaviors to desired team performance.
Factors influencing blockchain adoption in accounting and auditing in the face of Industry 4.0: a multi-criteria decision-making approach
Authors: Jena R. K. 
Published: January 2025

Purpose
Thus the purpose of this study is to prioritize the factors affecting the blockchain technology in accounting and auditing practices. Industry 4.0 technology has revolutionized how businesses and professionals perform tasks. Blockchain technology is one such Industry 4.0 technology and has the potential to change the processes used to measure and communicate financial information. More research, particularly in India, is required to better comprehend the use of blockchain in accounting and auditing.

Design/methodology/approach
This research used multi-criteria decision-making (MCDM)-based qualitative research approach (“interpretive structural modeling [ISM]” and “cross-impact matrix multiplication [MICMAC]”) to rank and classify the factors affecting blockchain adoption in accounting and auditing.

Findings
This study classified environmental, technological and management factors according to driving and dependent powers that enable blockchain adoption in accounting and auditing. The findings of this study showed that top management and government support were the most critical determinants of blockchain adoption in Indian accounting and auditing firms.

Originality/value
This research is one of the few qualitative studies examining the factors affecting blockchain adoption in accounting and auditing processes. After the Indian Government’s 2021 blockchain policy, this study is among the first to assess blockchain adoption factors using multi-criteria decision-making techniques in India to the best of the authors’ knowledge. The findings will assist stakeholders (government, technocrats, service providers, etc.) in increasing blockchain penetration in India’s accounting and auditing sectors.
A systematic review on employee happiness: three-decade review, synthesis and research propositions
Authors: Dhiman Neeraj , Kanojia Honey , Jamwal Mohit , Kumar Sachin 
Published: January 2025

Purpose
This study presents a systematic review of “employee happiness” research from 1991–2023. In this way, this study aims to critically appraise the existing literature, and synthesize themes, thereby, paving a clearer understanding of the construct, along with providing the future research agenda.

Design/methodology/approach
By adopting a systematic approach, this study followed scientific procedures and rationales for systematic literature reviews for article selection. A total of 57 articles were finally chosen after a careful examination from 110 selected journals.

Findings
The current study identified three major themes after evaluating the selected literature on Employee happiness: (1) work, family and personal blend, (2) organizational support, and (3) Ebullience sentiment. Amidst an ambiguous usage of several related constructs in employee happiness research, the review provided a clear definition of “employee happiness” along with proposing crucial research directions.

Originality/value
There is a lack of systematic reviews on employee happiness in the existing literature. Thus, by far, this effort is one of the earliest endeavors that researchers undertook toward understanding employee happiness.
The impact of port service quality on customer satisfaction: the case of clearing and forwarding agents in Kuwait Shuwaikh Port
Authors: Alsalfiti Ahmed , Notteboom Theo 
Published: January 2025

PurposeThe research identifies the factors influencing the satisfaction of clearing and forwarding (C&F) agents in Shuwaikh Port, Kuwait, based on port service quality (PSQ). The research is based on the ROPMIS model to study PSQ. This research adds value to PSQ studies and the need to explore this concept further in the context of Kuwait Shuwaikh port.Design/methodology/approachData were collected from 49 C&F agents using a survey method. A self-administered questionnaire was designed using extant literature. The data are analyzed using SPSS to carry out the validity and reliability, followed by correlation and regression analyses to study the ROPMIS factors on C&F satisfaction.FindingsThe findings indicate that as per correlation analysis, all five PSQ factors are significant with C&F satisfaction. However, the regression results indicate that out of the five PSQ factors, only resources-related PSQ and management-related PSQ are significant towards C&F satisfaction.Research limitations/implicationsThis research implies a policy review need for current port operations and emphasizes understanding customer (C&F) expectations. PSQ improvements lead to economic benefits for the country by enhancing the effectiveness of logistics and port management.Practical implicationsThe findings promote the need to use technology for improved management, which could enhance Shuwaikh port’s service quality in Kuwait, meet C&F agents' needs and maintain industry competitiveness.Originality/valueThis paper fulfills an identified need to study PSQ in Kuwait government-operated ports to provide better end-user experience and satisfaction.
Boundary conditions on the dark side of high-performance work systems: leader-member exchange as a job resource
Authors: Yu Jiawei , Abdul Hamid Roshayati , Du Lin 
Published: January 2025

PurposeEmployee emotional exhaustion is widely recognized as a hidden cost associated with high-performance work systems (HPWS). To delve deeper into the pathway from HPWS to emotional exhaustion and explore the boundary conditions capable of mitigating these hidden costs, this study, building upon the job demands-resources (JD-R) model, proposes that psychological strain serves as a mediator and theorizes that leader-member exchange (LMX) operates as a job resource serving to buffer the adverse effect of HPWS-induced psychological strain on emotional exhaustion.Design/methodology/approachThis study adopts a time-lagged research design with a four-week interval to test the proposed hypotheses. Two waves of survey data were collected from 398 respondents in the Chinese state-owned banking sector.FindingsThe findings largely supported our hypotheses. Specifically, the results indicated that psychological strain mediated the relationship between HPWS and emotional exhaustion. In addition, LMX, as a job resource, moderated the indirect relationship between HPWS and emotional exhaustion. High-quality LMX reduced the likelihood of employees experiencing psychological strain caused by HPWS, thereby buffering the manifestation of emotional exhaustion.Originality/valueBy innovatively introducing the LMX as a job resource, this study demonstrates that the hidden costs of HPWS are not inevitable. This finding relieves organizational researchers and practitioners from the dilemma of choosing between enhancing performance and alleviating employee emotional exhaustion when implementing HPWS.
The power of independent reading
Authors: Mackenzie Noella 
Published: January 2025

PurposeTo become good at anything we need to practice. However, in the classroom context, much of the reading time is devoted to instruction rather than practice. Reading practice should be daily. Text choice, motivation and reading for pleasure all interact to support implicit learning.Design/methodology/approachReview and synthesise the literature discussing independent reading in the primary classroom.FindingsThe more a student reads, the more their reading improves. Independent reading promotes implicit learning. Outcomes of independent reading include motivation to read more, expanded vocabulary, grammar and spelling knowledge, the ability to read fluently, improved comprehension skills, increased general knowledge and overall academic achievement. Writing and oral language skills can also improve if opportunities are created for talking about books and independent reading is used as inspiration and models for writing.Research limitations/implicationsThe research is based on existing literature. The limit of 3,000 words restricts the depth of the paper.Practical implicationsThe finding supports teachers to include independent reading in their daily timetable. Suggestions for establishing independent reading are provided at the end of the paper.Social implicationsEngagement in reading “acts as a mediator of gender and socio-economic status and… can help leverage social change” (OECD, 2021, p. 28). Independent reading benefits students in multiple ways and helps close the gap between those who have access to books at home and those who do not.Originality/valueA great deal of emphasis is placed on extrinsic reading motivation and test scores. Independent reading provides the opportunity for growth and development in all areas of literacy learning through implicit learning and enjoyment.
Real‐world assessment of the patient profile, clinical characteristics, treatment patterns, and outcomes associated with erythropoietic and X‐linked protoporphyria
Authors: Silver Samuel M. , Houghton Katherine , Hitchens Abby , Ansquer Valérie Derrien , Ciepielewska Malgorzata 
Published: January 2025

AbstractErythropoietic protoporphyria (EPP) and X‐linked protoporphyria (XLP) are rare genetic disorders. There are limited data regarding how these disorders are managed in real‐world settings. The aim of this study was to document the characteristics and treatment patterns among patients diagnosed with EPP or XLP in general real‐world settings in the United States. We, therefore, conducted a retrospective medical record review of patients diagnosed with EPP or XLP on or before July 1, 2020. Data were analyzed for patients with EPP (n = 299) and XLP (n = 91). Outcomes included demographic and clinical characteristics, diagnostic testing, therapy recommendations, office visits, emergency department visits, and hospitalizations. Costs were assigned to healthcare resources. Mean (standard deviation [SD]; median) time between the first symptom documented in the medical records and diagnosis was 2.9 (5.1; 1.3) years. The most common pre‐diagnostic tests were liver function, total plasma and erythrocyte protoporphyrin, genetic tests, and renal function. Patients were advised to use sunscreen (85%) or modify their lifestyle (83%). Within 12 months of diagnosis, the mean (SD; median) number of office visits, emergency department visits, and inpatient hospitalizations related to EPP or XLP were 4.0 (3.5; 3.0), 0.8 (1.6; 0), and 0.4 (1.3; 0), respectively. Patients with EPP or XLP have several unmet needs, including timely and accurate diagnosis, symptom relief, and efficacious prevention of phototoxic reactions.
A global synthesis of the ecological effects of co‐invasions
Authors: Ahmad Rameez , Lone Showkeen A. , Rashid Irfan , Khuroo Anzar Ahmad 
Published: January 2025

Abstract

Globally, the majority of ecosystems are being invaded by multiple co‐occurring alien species. While most of the quantitative syntheses have focused on single invasive species impacts, a global‐scale quantitative synthesis on the interaction effects of species co‐invasions across multiple taxa and levels of ecological organization remain largely unexplored.

We address this knowledge gap by synthesizing quantitative information from 256 effect sizes published in 36 studies, that reported the individual and interaction effects of co‐occuring alien plant and animal species.

Although, our meta‐analysis showed that the mean interaction effect of co‐invasions across a range of variables was antagonistic (i.e. combined effect less than the sum of individual effects), the vote‐counting revealed additive interaction effects (i.e. combined effect equal to the sum of individual effects) to dominate individual observations. Also, the frequency of interaction effect types varied significantly with response variables, ecological organization, ecosystems, continents and study design, thereby indicating the role of these ecological characteristics in shaping co‐invasion interaction effects.

Synthesis. Overall, our synthesis highlights the need for incorporating local ecological complexities in future co‐invasion impact research to better predict their interaction effect on biodiversity and ecosystem functioning across spatio‐temporal scales. Looking ahead, we call for concerted research efforts on the ecological impacts of co‐invasions to unravel the causes of variability in interaction outcomes.
Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4+ T Cells
Authors: Xie Chen , Zhang Hong‐Lian , Yuan Jun , Zhang Ye , Liu Yang‐Chun , Xu Quan , Chen Li‐Ru 
Published: January 2025

ABSTRACTMyasthenia gravis (MG) presents with symptoms that significantly affect patients' daily lives. Long‐term MG therapies may lead to substantial side effects, predominantly due to prolonged immune suppression. Sirt6, which plays a vital role in maintaining cellular homeostasis and is recognised for its involvement in cytokine production in immune cells, has not yet been explored in relation to MG. PBMCs and CD4+ T cells were isolated from blood samples. RT‐qPCR, western blot and ELISA were used to assess the expression of target genes and proteins. Flow cytometry was used to identify the subsets of T helper cells. Co‐IP was conducted to investigate the interaction between USP9X and Sirt6. Finally, the experimental autoimmune myasthenia gravis (EAMG) model was established. In MG patients, Sirt6 levels were downregulated compared to healthy controls. Sirt6 overexpression led to a reduction in Th1 and Th17 cell populations while augmenting Treg cells in PBMCs. USP9X interacted with Sirt6, leading to its deubiquitination and stabilisation. Elevated Sirt6 levels subsequently mitigated symptoms in the EAMG model. The stabilisation of Sirt6, mediated by USP9X, has been found to relieve symptoms of EAMG by influencing the subtypes of T helper cells. This highlights the promising potential of Sirt6 as a viable therapeutic target in the treatment of MG.
Characterization of sulfakinin and its role in larval feeding and molting in Spodoptera frugiperda
Authors: Yu Ming‐Qing , Linghu Jun‐Hong , Xie Hua‐Yan , Li Gang , Zhu Feng , Smagghe Guy , Gui Shun‐Hua , Liu Tong‐Xian 
Published: January 2025

AbstractFeeding and molting are particularly important physiological processes for insects, and it has been reported that neuropeptides are involved in the nervous regulation of these 2 processes. Sulfakinin (SK) is an important neuropeptide that is widely distributed among insects and plays a pivotal role in regulating feeding, courtship, aggression, and locomotion. In this study, we investigated the involvement of SK in feeding and molting on a highly notorious pest insect, the fall armyworm, Spodoptera frugiperda. SK transcript levels were found in all larval stages and there was a predominant expression of SK in the brain of 5th instar larvae. By immunostaining, SK was detected in 2 pairs of cells in the median protocerebrum. But during prolonged periods of starvation, there was a significant reduction in SK messenger RNA levels; however, subsequent refeeding led to a notable increase. To investigate the role of SK in feeding and molting, SK was silenced in S. frugiperda larvae through RNA interference. This resulted in a significant increase in food intake, weight gain, and the molting process happened more rapidly in the double‐stranded SK‐treated larvae compared to the controls. Conversely, injection of sulfated SK peptide (sSK) caused opposite effects. Interestingly, SK‐knockdown in larvae resulted in increased levels of 20‐hydroxyecdysone and also of the expression of some of it signaling pathway genes. Altogether, this study highlights the important role played by SK in regulating feeding and molting in S. frugiperda.
DeepQA: A Unified Transcriptome‐Based Aging Clock Using Deep Neural Networks
Authors: Qi Hongqian , Zhao Hongchen , Li Enyi , Lu Xinyi , Yu Ningbo , Liu Jinchao , Han Jianda 
Published: January 2025

ABSTRACTUnderstanding the complex biological process of aging is of great value, especially as it can help develop therapeutics to prolong healthy life. Predicting biological age from gene expression data has shown to be an effective means to quantify aging of a subject, and to identify molecular and cellular biomarkers of aging. A typical approach for estimating biological age, adopted by almost all existing aging clocks, is to train machine learning models only on healthy subjects, but to infer on both healthy and unhealthy subjects. However, the inherent bias in this approach results in inaccurate biological age as shown in this study. Moreover, almost all existing transcriptome‐based aging clocks were built around an inefficient procedure of gene selection followed by conventional machine learning models such as elastic nets, linear discriminant analysis etc. To address these limitations, we proposed DeepQA, a unified aging clock based on mixture of experts. Unlike existing methods, DeepQA is equipped with a specially designed Hinge‐Mean‐Absolute‐Error (Hinge‐MAE) loss so that it can train on both healthy and unhealthy subjects of multiple cohorts to reduce the bias of inferring biological age of unhealthy subjects. Our experiments showed that DeepQA significantly outperformed existing methods for biological age estimation on both healthy and unhealthy subjects. In addition, our method avoids the inefficient exhaustive search of genes, and provides a novel means to identify genes activated in aging prediction, alternative to such as differential gene expression analysis.
Exploring diagnostic stewardship in the emergency department evaluation of pediatric abdominal pain in a statewide quality collaborative
Authors: Janke Alexander T. , Michelson Kenneth A. , Kocher Keith E. , Seiler Kristian , Macy Michelle L. , Nypaver Michele , Mahajan Prashant V. , Arora Rajan , Mangus Courtney W. 
Published: January 2025

AbstractBackgroundDiagnostic stewardship is the effort to optimize diagnostic testing to reduce errors while avoiding overtesting and overtreatment. Abdominal pain and appendicitis in children are essential use cases. Delayed diagnosis of appendicitis can be dangerous and even life‐threatening, but overtesting is harmful.MethodsWe conducted a retrospective cohort study of children aged 5–17 years presenting with abdominal pain to 26 EDs within the Michigan Emergency Department Improvement Collaborative (MEDIC) from May 1, 2016, to February 29, 2024. We defined two outcome measures summarized by ED. First, we describe the cross‐sectional imaging:appendicitis visits ratio, defined as the count of ED visits resulting in any cross‐sectional imaging (CT or MRI) divided by the count of ED visits with a diagnosis of appendicitis. Second, we describe the delayed diagnosis rate, defined by an ED visit for abdominal pain resulting in a discharge and subsequent return visit with a diagnosis of appendicitis within 7 days.ResultsThe sample included 120,112 pediatric visits for abdominal pain at 26 EDs; 4967 (4.1%) were diagnosed with appendicitis. The cross‐sectional imaging:appendicitis visits ratio varied by site, from as low as 0.2 (95% confidence interval [CI] 0.1–0.2) at a pediatric site to as high as 7.9 (95% CI 4.8–16.4) at an urban ED. The proportion of pediatric ED visits for abdominal pain that resulted in an identified delayed diagnosis of appendicitis was 0.1% (141/120,112). All but four sites had fewer than 10 cases of delayed diagnosis across the study period.ConclusionsIn this retrospective cohort study of 120,000+ ED visits for pediatric abdominal pain, we found that the ratio of visits with cross‐sectional imaging to diagnosed cases of appendicitis varied widely across EDs. Delayed diagnosis of appendicitis was uncommon. Adherence to best practices and improved imaging quality may hold promise to improve diagnostic stewardship for children with abdominal pain across EDs.