bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and tolerability of COVID-19 vaccines in patients with cancer: a single center retrospective analysis
Authors: Nuzzo Amedeo , Manacorda Simona , Sammarco Enrico , Sbrana Andrea , Bazzurri Serena , Paolieri Federico , Manfredi Fiorella , Mercinelli Chiara , Ferrari Marco , Massaro Giulia , Bonato Adele , Salfi Alessia , Galli Luca , Morganti Riccardo , Antonuzzo Andrea , Cremolini Chiara , Masi Gianluca 
Published: April 2022

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused a worldwide challenging and threatening pandemic. Multinational, placebo-controlled, observer-blinded trials were conducted since the beginning of pandemic because safe and effective vaccines were needed urgently. In most trials of COVID-19 vaccines patients (pts) affected by malignancies or on treatment with immunosuppressive drugs were excluded. Patients and methods: At our Centre a retrospective study was conducted in this subset of population to investigate safety and tolerability of COVID-19 vaccines; 377 pts with solid tumor on treatment were enrolled. Vaccine-related adverse events were recorded using a face-to-face questionnaire including a toxicity grading scale. Most of the pts (93.5%) has got mRNA vaccine as indicated by Italian health ministry guidelines. Mean age was 66 years (range 27-87), 62.3% of the pts was older than 65 years and 68.4% had at least one additional comorbidity. The majority (86.2%) of pts was at metastatic stage and 29.4% received immunotherapy-based treatment. For statistical analysis multivariate binary logistic regression models were performed and linear regression models were applied, using SPSS technology v.27.Results: Incidence of adverse events was higher after the second dose than after the first one (72.6% vs 67.4%). Adverse events were mild and transient, ended in a few days without any sequelae. No severe or uncommon side effects were recorded. In multivariate analysis we found that female gender was associated with a greater risk of more severe and longer lasting adverse events, and a higher risk of adverse events was found for pts treated with immunotherapy. Conclusions: Our results demonstrate that COVID-19 vaccines were safe and well-tolerated in our population.
Seroprevalence and risk factors associated with Toxoplasma gondii and Chlamydia abortus infection in domestic small ruminants in Cameroon
Authors: Nankam Roland Chimi , KOUAMO Justin , Kouengoua Armelle Prudence Kouengoua , TCHINZE Grace Jedida TOUKEM , DZOUSSE Müller FOTSAC , GAPGUEU Sandra Vanessa , NOUMEDEM Ranyl NGUENA GUEFACK , NGOULA Ferdinand 
Published: April 2022

Abstract
Toxoplasmosis and abortive chlamydia continues to spread and cause considerable economic losses in small ruminant farms. The objectives of this study were to determine the seroprevalence and highlight the risk factors associated with Toxoplasma gondii and Chlamydia abortus infection in small ruminants in Cameroon. A cross-sectional study was conducted in 200 small ruminant farms during a period from April to October 2021. A total of 1061 small ruminants were sampled and the sera obtained were analysed using the indirect multi-species ELISA test for toxoplasmosis and abortive chlamydia at the national veterinary laboratory. A questionnaire was constructed to collect information about ﬂock management and animal risk factors possibly associated with Toxoplasma gondii and Chlamydia abortus infection in goats and sheep. Overall, 329 small ruminants tested positive for Toxoplasma gondii and 45 for Chlamydia abortus with a prevalence of 31.01% (95% CI: 28.23 - 33.79) for toxoplasmosis and 4.24% (95% CI: 3.03 - 5.45) for chlamydia abortus, respectively. However, a significant co-infection of 1.82% (95% CI: 0.37 - 3.27) was obtained between Toxoplasma gondii and Chlamydia abortus (p=0.02). Univariate analysis showed that region (p=0.0001), species (p=0.0001), sex (p=0.0002), age (p=0.0002) and breed (p=0.01) were the risk factors associated with the seroprevalence of Toxoplasma gondii in small ruminant farms in Cameroon; while breed (p=0.0001) and the presence of abortion (p=0.0003) were identified as risk factors strongly associated with the seroprevalence of Chlamydia abortus . These results could be used to implement efﬁcient management measures to prevent and control Toxoplasma gondii and Chlamydia abortus infection in goats and sheep in Cameroon.
Development of ZnO-PVA based Polymer Composite Films by Solution Casting Approach for Performance Maximization of Organic Solar Cells
Authors: M. Fazal Ur Rehman , Qayyum Iqra , Raza Aoun , Zahra Manzar , Zada Zeeshan 
Published: April 2022

Abstract
Organic Solar Cells (OSCs) are becoming incredibly popular in photovoltaics because to their solution tunability, flexibility, low temperature development, environmental friendliness and ease of integration. Despite these benefits, the energy conversion efficiency of OSCs is lowest than that of other cells based on solar energy. As a result, the emphasis will unavoidably be on boosting the efficiency of OSCs. With this concept, we created and incorporated a ZnO-PVA nanocomposite (NCs) film to see whether we could improve its efficiency. ZnO nanoparticles with several different concentrations in a PVA matrix were used to prepare the NCs films following the Solution Casting Approach. Each sample of all NCs films was analyzed using OSCs. The efficiency of OSCs differs significantly before and after application of prepared NCs coating. When applied on OSCs with structure [Carbon Fiber)/(CuO/Epoxy Resin)/( ZnO/Epoxy Resin)/Carbon Fiber], the film with an ideal Wt.% of ZnO; 14.50 percent and PVA; 85.50 percent, exhibits a substantial increase in performance efficiency.
Assessment water balance through different sources of precipitation and actual evapotranspiration
Authors: Neto Arthur Kolling , Ribeiro Rayssa Balieiro , Pruski Fernando Falco 
Published: April 2022

Abstract

Understanding the processes related to the water circulation in the watershed is essential for the development of hydrological studies, estimates of water availability and improvements in the management and planning of water resources. In this regard, the objective of this work was to evaluate the water balance (WB) behavior, resulting from the combination of precipitation (PPT) and actual evapotranspiration (ETR) from different methodologies, concerning the representativeness of the physical and climatic conditions of the watershed. For this purpose, four sources of precipitation data (IMERG, TMPA, TerraClimate and IDW interpolation of the data from rain gauge stations) and four from actual evapotranspiration (MOD16, GLEAM, MOD16rsp and TerraClimate) were considered to estimate the water balance in the Paraguaçu river watershed. The precipitation products were analyzed by means of statistical and physical analysis and the ETR products were evaluated according to the spatial distribution and magnitude of the values ​​along the watershed. Finally, the assessment of the water balance was carried out considering the representativeness along the watershed. The results indicated that the variables (PPTTC and ETRTC), obtained from the TerraClimate database, showed better sensitivity to variations in the spatial distribution of each region, characterizing the orographic effect and the semi-arid climate, leading to the best performances and the best combination for the water balance (WBTC_TC). Therefore, WBTC_TC was the most representative variable of water circulation conditions in the watershed.
Performance Improvement of AWGN Filters by INLP Technique
Authors: fatnassi soumaya , YAHIA MOHAMED , ALI TARIG , MORTULA MARUF , ABDELFATTAH RIADH 
Published: April 2022

Abstract
In this paper, an extensive research on grayscale images applying spatial domain filtering technique to remove additive white Gaussian noise (AWGN) has been developed. However, the existing average based filters have a main limitation which is the exploitation of the statistics of the original noisy image only. Nevertheless, in the infinite number of looks prediction (INLP) technique, in addition to the statistics of the original image, the statistics of the filtered images are also used to elevate the filtering performance. A linear regression between the filtered pixels and their variances for various window sizes has been achieved. The aim of this work is to extent the INLP filter, which is originally used with multiplicative noise, to AWGN image filtering. A theoretical effort has been conducted to derive a linear rule between the filtered pixels and their variances of AWGN digital images. Then, a linear regression has been applied to compute the INLP filtering pixels. Experiments carried out on gray-level images show the potentiality of the approach compared to other established algorithms, in terms both of noise reduction and spatial detail preservation.
LCK and its related molecules as potential biomarkers in rheumatoid arthritis
Authors: Chen Xuemeng , Xie Li , Jiang Yi , Zhang Ronghua , Wu Wei 
Published: April 2022

Abstract
Background
Rheumatoid arthritis (RA) is a type of systemic immune disease characterized by chronic inflammatory disease of the joints. However, the etiology and underlying molecular events of RA are unclear. Here, we applied bioinformatics analysis to identify the potential biomarkers involved in RA.
Methods
The three microarray datasets (GSE1919、GSE10500 and GSE55457) were downloaded from the Gene Expression Omnibus (GEO) database. We used the R software screen the differentially expressed genes (DEGs). These DEGs shared by the three microarray datasets were further identified. Next, we carried out functional enrichment analysis using the Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG). Then, the hub genes with a relatively high number of connections to other DEGs, were identified by Cytoscape. Other bioinformatics methods are also performed, including protein–protein interaction (PPI) network analysis and construction of miRNA–hub gene networks and transcription factors (TF)–hub gene networks.
Results
A total of 115 overlapping DEGs were identified in this study. Subsequently, we constructed a PPI network encoded by these DEGs and identified 10 genes closely associated with RA – LCK, GZMA, GZMB, CD2, LAG3, IL-15, TNFRSF4, CD247, CCR5, and CCR7. Furthermore, in the miRNA–hub gene networks, we screened out has-miR-146a-5p, which is the miRNA controlling the largest number of hub genes. Finally, we found some transcription factors that closely interact with hub genes, such as FOXC1, GATA2, YY1, RUNX2, SREBF1, CEBPB, and NFIC.
Conclusions
In summary, bioinformatics analyses were used to identify DEGs to find potential biomarkers that may be associated with RA. This study successfully predicted that LCK, FOXC1 and has-mir-146a-5p can be used as potential biomarkers of RA. Our study may have potential implications for future prediction of disease progression in symptomatic RA patients, and has important significance for the pathogenesis and targeted therapy of RA.
The effect of intravenous iron supplementation on exercise capacity in iron-deficient but not anaemic patients with chronic kidney disease: study design and baseline data for a multicentre prospective double-blind randomised controlled trial
Authors: Greenwood Sharlene A , Beckley-Hoelscher Nicholas , Asgari Elham , Ayis Salma , Baker Luke A , Banerjee Debasish , Bhandari Sunil , Bramham Kate , Chilcot Joseph , Burton James , Kalra Philip A , Lightfoot Courtney J , McCafferty Kieran , Mercer Thomas H , Okonko Darlington O , Oliveira Benjamin , Reid Chante , Smith Alice C , Swift Pauline , Mangelis Anastasios , Watson Emma , Wheeler David C , Wilkinson Thomas J , Reid Fiona , Macdougall Iain C 
Published: April 2022

Abstract
Background: Many people living with chronic kidney disease (CKD) are iron deficient, even though they may not be anaemic. The Iron and Muscle study aims to evaluate whether iron supplementation reduces symptoms of fatigue, improves muscle metabolism, and leads to enhanced exercise capacity and physical function. We report here the trial design and baseline characteristics. Methods: This is a prospective, double-blind multicentre randomised controlled trial (RCT) including 75 non-dialysis CKD patients with iron deficiency but without anaemia. Patients were randomly (1:1) assigned to either: i) intravenous iron therapy, or ii) placebo, with concurrent recruitment of eight CKD non-iron deficient participants and six healthy volunteers. The primary outcome of the study is the six-minute walk test (6MWT) distance between baseline and four-weeks. An additional exercise training programme for patients in both groups was initiated and completed between 4 and 12 weeks, to determine the effect of iron repletion compared to placebo treatment in the context of patients undertaking an exercise programme. Additional secondary outcomes include fatigue, physical function, muscle strength, muscle metabolism, quality of life, resting blood pressure, clinical chemistry, safety and harms associated with the iron therapy intervention and the exercise training intervention, and hospitalisations. All outcomes were conducted at baseline, 4, and 12 weeks, with a nested qualitative study, to investigate the experience of living with iron deficiency and intervention acceptability. The cohort have been recruited and baseline assessments undertaken. Results: 75 individuals were recruited. 44% of the randomised cohort were male, the mean (SD) age was 58 (14) years, and 56% were White. Body mass index was 31 (7) kg/m2; serum ferritin was 59 (45) μg/L, transferrin saturation was 22 (10) %, and haemoglobin was 125 (12) g/L at randomisation for the whole group. Estimated glomerular filtration rate was 35 (12) mL/min/1.73 m2 and the 6MWT distance was 429 (174) m. Conclusion: The results from this study will address a substantial knowledge gap in the effects of intravenous iron therapy on exercise capacity, physical function, fatigue, and muscle metabolism, for non-dialysis patients with CKD who are iron-deficient but not anaemic. Trial Registration: EudraCT: 2018-000144-25 Registered 28/01/2019.
Examining the Unique Associations of Hedonic Hunger and 12- and 24-Month Weight Loss Outcomes
Authors: Crane Nicole T. , Butryn Meghan L. , Gorin Amy A. , Lowe Michael R. , Schulte Erica M. 
Published: April 2022

Abstract
Purpose: Improvements in hedonic hunger (HH; reward-driven eating outside of biological need) during behavioral weight loss (BWL) treatments relate to greater weight loss. However, it is unknown how HH is associated with BWL outcomes when accounting for the effects of theoretically similar constructs, including uncontrolled eating and food craving, and relevant contextual factors, like exposure to the obesogenic food environment. Methods: Adults (N = 283) in a 12-month BWL program were weighed at baseline, post-treatment (12 months) and follow-up (24 months), and completed questionnaires assessing HH, food craving, uncontrolled eating, and their home food environment (HFE). Results: HH, uncontrolled eating, craving, and the obesogenic HFE improved during BWL and reductions were maintained at 24 months. Decreases in HH from baseline to post-treatment were associated with higher concurrent weight loss, but not when accounting for concurrent improvements in cravings and uncontrolled eating. At 24 months, decreases in cravings accounted for more variability in weight loss than changes in HH, but improvement in HH was a stronger predictor of 24-month weight loss than decreases in uncontrolled eating. Changes to the obesogenic HFE failed to predict weight loss, regardless of baseline levels of HH.Conclusion: This study adds novel information on which individual and environmental factors are most strongly associated with short- versus long-term weight control, which can impact intervention development. Improvements to the obesogenic HFE may be less important than previously conceived, as BWL participants (with varying levels of HH) were able to achieve weight loss regardless of changes to the HFE.Level of Evidence: Level II: Evidence obtained from well-designed controlled trials without randomization
Transarterial chemoembolization versus liver resection as first-line treatment for hepatocellular carcinoma occurring exclusively in caudate lobe: A retrospective propensity matching analysis
Authors: Yang Biao , Yuan MinLan , Chen MinYang , Zhang Yuzu , Yang Ting , Gao Yuemei , Liao ZhengYin , Wu Hao 
Published: April 2022

Abstract
Background
Treatment of hepatocellular carcinoma (HCC) in the caudate lobe is technically challenging. This retrospective study aims to evaluate the clinical outcome of both super selective transcatheter arterial chemoembolization (TACE) and liver resection (LR) for HCC occurring in the caudate lobe.
Methods
From January 2008 to September 2021, a total of 129 patients were diagnosed with HCC exclusively located in the caudate lobe. We used the Cox proportional hazard model to analyze the potential clinical factors and established prognostic nomograms with interval validation.
Results
78 patients received TACE, and 51 patients received LR. The overall survival (OS) rates (TACE vs. LR) at 1, 2, 3, 4, and 5 years were 83.9% vs. 71.0%, 74.2% vs. 61.3%, 58.1% vs. 48.4%, 45.2% vs. 45.2%, and 32.3% vs. 25.0%, respectively. However, the subgroup analysis revealed that TACE is superior to LR for treating patients with BCLC-B stage in the entire cohort (P = 0.002). Interestingly, we found no difference in BCLC-A stage HCC between TACE and LR (P = 0.6). Based on Child-Pugh A and B, TACE tends to have better OS than LR (P = 0.081) and (P = 0.16), respectively. The multivariate analysis showed Child-Pugh score, Barcelona Clinic Liver Cancer (BCLC) stage, ascites, alpha fetoprotein (AFP), the largest tumor size, and anti-HsCV is related to OS. Predictive nomograms for 1-, 2-, 3- years were performed.
Conclusion
Based on this study, TACE may be better for HCC in the caudal lobe than liver resection, considering a longer overall survival time.
DFT-based ab initio study of the electronic and vibrational properties of the crystal structure of orthorhombic dansyl chloride
Authors: Venâncio José Robson da Costa , Frazão Nilton Ferreira 
Published: April 2022

Abstract
The use of markers of organic compounds by dansyl chloride (DNS-Cl) through fluorescence can be widely used in areas such as pharmacology, toxicology, organic synthesis, and biochemistry. The theoretical computational study of the molecular structure of DNS-Cl in crystalline form is not reported in the literature. In this work, we calculate the structural, electronic, optical, and vibrational properties. Using density functional theory, we consider general gradient approximation with dispersion correction (GGA+TS) and local density approximation (LDA-CAPZ). We hope that this work will be of great importance for the theoretical study of the crystal structure of DNS-Cl and serve as a database for future studies.
Identification of potential biomarkers for endometrial carcinoma based on WGCNA
Authors: Wang Lei , Ma Ying , Liu Zhe , Zhang Yu , Liu Xudong , Wang Yafan , Zhao Lijun , Fan Jinke , Peng Tao , Li Rui , Chen Yuxuan , Song Xinqiang 
Published: April 2022

Abstract
Background
Endometrial carcinoma (EC) is a group of malignant epithelial tumors occurring in the endometrium. With the increasing incidence of recent years, identifying the molecular mechanisms associated with endometrial carcinoma has become particularly important for the early diagnosis and treatment of cancer.
Methods
RNA-seq data and clinical information of patients were downloaded from The Cancer Genome Atlas (TCGA) database. In addition, functional enrichment analysis, differential expressed gene (DEG) analysis and weighted gene co-expression network analysis (WGCNA) were conducted. Next, hub genes associated with cancer progression were obtained by screening the module genes of interest, validated by survival analysis by GEPIA (p < 0.05). Finally, mutational analysis and immunohistochemistry validation were performed on the hub genes.
Results
We identified 3,308 genes with significant variants and screened them. And they were mainly associated with reproductive structure development, positive regulation of cytosolic calcium ion concentration, and cell − cell adhesion via plasma − membrane adhesion molecules. Weighted gene co-expression network analysis (WGCNA) identified six modules. By constructing a co-expression network, the turquoise module was found to be the most important module in predicting tumors. Apart from that, the turquoise module was negatively associated with cancer and was strongly correlated with patient weight, age, degree of tumor invasion and pregnancy status. Next, Survival analysis showed that NCMAP, ACTG2, TRPC1, RBMS3 are highly correlated with cancer progression. Finally, mutation analysis and IHC experiments further confirmed that TRPC1 plays a vital role in the occurrence and development of EC.
Conclusion
In summary, our research indicates that NCMAP, ACTG2, TRPC1, RBMS3 may play a central role in diagnosing and treating of endometrial carcinoma. TRPC1 may be a novel biomarker of the disease. These hub genes may provide a theoretical basis for targeted therapy against EC.
Ornithine decarboxylase antizyme 2 (OAZ2) in human colon adenocarcinoma: a potent prognostic factor associated with immunity
Authors: Zhang Shengjie , Ma Xinyu , Qu Lishuai , Zhou Guoxiong , Zhu Bingye , cao wei 
Published: April 2022

Abstract
BackgroundsTill now, few researches have been focused on the role OAZ2 gene played in colorectal cancer about prognostic and immunologic. In this article, we are aiming to explore more specific role and mechanism of OAZ2 in colon adenocarcinoma (COAD).MethodsThe expression level of OAZ2 and related clinical data were all downloaded from online database The Cancer Genome Atlas (TCGA). Uni- and multivariate Cox hazard regression analyses were performed to identify potent prognostic indicators. Gene set enrichment analysis (GSEA) and nomogram model was utilized to find interrelated signaling pathways and evaluate prognostic value separately. Associations between OAZ2 and immunity were also figured out in this research.ResultsOAZ2 gene has been detected low expression levels between normal and tumor tissues across multitudinous tumors. Box-plot analysis revealed that OAZ2 had low expression level in COAD patient-tissues (P < 0.05). Uni- and multivariate Cox regression analysis were utilized to conform that OAZ2 could work as a prognostic indicator independently (P < 0.05). GSEA was applied to find two OAZ2-related signaling pathways including cardiac muscle contraction and oxidative phosphorylation pathways. Besides, a model of nomogram was set up successfully by us for prediction of survival rates of COAD patients. Finally, through analyzation about PPI and immunity, we found that 10 OAZ2-related genes and OAZ2 expression level was closely connected with immunity such as tumor mutational burden (TMB), microsatellite instability (MSI) as well as tumor immune infiltration, tumor microenvironment, immune check-point molecules and immune cells pathway.ConclusionsOAZ2 was proved to be a useful indicator in COAD patients for prognosis closely-related to OS. We found OAZ2 had strong connections with immunity. Further study about the role of OAZ2 in prognosis in vivo and in vitro need to be carried out in our follow-up research.