bluuebunny/crossref_metadata_2025_split huggingface dataset:
El uso de las Tecnologías de la Información y Comunicación (TIC) para el desarrollo de la alfabetización informacional en niños en formación escolar.
Authors: Pelissaro Regina Dioga 
Published: November 2022

La Sociedad de la Información y del Conocimiento es el agente transformador de la sociedad en un ecosistema informacional y demanda la alfabetización informacional, que necesita ser desarrollada por los individuos. Las Tecnologías de la Información y Comunicación (TIC) permiten elaborar, difundir, comunicar e interactuar con la información y están relacionadas a la evolución de la sociedad. La escuela es el espacio ideal para empezar a desarrollar las habilidades informativas y el contacto con las TIC. El estudio analiza los beneficios del estímulo al uso de las TIC en la escuela para desarrollar, en los alumnos, la alfabetización informacional. La metodología utilizada es el análisis de 6 artículos publicados en los últimos 15 años. Los resultados de los análisis constatan la importancia del uso de las TIC en el desarrollo de la alfabetización informacional en los alumnos y que los profesores necesitan mejor formación respecto a la utilización de las TIC para enseñanza en clase y como objeto de capacitación en habilidades informacionales.El estudio concluye que las TIC están cambiando la forma de vida de las personas y deben ser recursos incorporados al día a día de los niños desde la educación primaria.
La Gamificación
Authors: Bengochea Gonzalo 
Published: November 2022

La Gamificación es un proceso donde entran en juego distintas mecánicas y técnicas propias de la identidad o esencia del diseño de juegos, que tiene como objetivo motivar a los participantes a conseguir propósitos específicos. Hay aspectos que no hacen a una propuesta de Gamificación, en vistas a diseñar una experiencia educativa y formativa. La Gamificación no implica precisamente la creación de un juego, no es un serious game, no es teoría de juegos y tampoco es diseñar fundamentalmente un sistema de recompensas o programas de fidelización. El juego en educación interpela al educador a problematizar las estrategias de enseñanza, buscando lograr la participación activa de los demás. Entendiendo que lo lúdico no pone el acento en el aprendizaje de contenidos, sino en la promoción de un entorno que estimule a cada estudiante en la construcción de un conocimiento propio cargado de significados personales.La motivación, en relación a las propuestas de Gamificación, nunca debe minimizarse simplemente a recompensas materiales por comportamientos, teniendo en cuenta que esto va conduciendo a la frustración continua por no conseguirlas. Dicha motivación puede identificarse desde dos tipos: intrínseca, que surge de factores propios de las personas, y extrínseca, que nace por elementos externos a la persona.El primer elemento que deben considerar en el proceso de diseño de una experiencia de Gamificación, es entender la fuerte similitud con la planificación didáctica de actividades o consignas específicas para diferentes propuestas o proyectos educativos que puede construir un educador. Estos elementos, entre otros (narrativa, dinámicas, mecánicas, elementos, objetivos),aparecen de manera articulada en el diseño de una experiencia de Gamificación.
Cangrelor Dosing and Monitoring for Prevention of Acute Systemic-to-Pulmonary Artery Shunt Thrombosis in Neonates
Authors: Anton-Martin Pilar , Matherne Emma , Kramer Jennifer , Joseph Noel , Rayburn Mark 
Published: November 2022

OBJECTIVE
Systemic-to-pulmonary artery shunts are amongst the most common palliative procedures performed in neonates with congenital heart defects. These procedures require immediate postoperative thromboprophylaxis to prevent life-threatening shunt thrombosis. The novel use of intravenous P2Y12 platelet receptor antagonists has led to a need for dosing recommendations and monitoring. This study aims to determine cangrelor dosing in neonates through laboratory assessment of P2Y12 receptor reactivity and adverse events.

METHODS
Observational retrospective cohort study on the use of cangrelor for thromboprophylaxis in the immediate postoperative period of neonates undergoing placement of systemic-to-pulmonary artery shunts in a tertiary children's hospital from March 2020 to March 2021.

RESULTS
Ten neonates receiving cangrelor post systemic-to-pulmonary artery shunt placement were included in the study. Median age and weight were 4 days (IQR, 2.75–5.25) and 3.49 kg (IQR, 3.1–3.75), respectively. Five (50%) patients received a 3.5-mm shunt, while the remaining patients received a 4-mm shunt. For thrombin inhibition, 5 (50%) patients received heparin and 5 (50%) received bivalirudin. Median cangrelor dose was 0.1 mcg/kg/min (IQR, 0.1–0.1). Median achieved P2Y12 reaction units (PRU) at this cangrelor dose was 127.5 (IQR, 72.5–173.75). No shunt thrombosis occurred in these patients; however, there was 1 minor hemorrhagic event.

CONCLUSIONS
Our study suggests that a cangrelor dose of 0.1 mcg/kg/min is associated with therapeutic PRU and prevents shunt thrombosis in neonates post systemic-to-pulmonary artery shunt, with minimal hemorrhagic complications.
A Preliminary Assessment of the Effects of Pharmacist-Driven Methadone Stewardship for the Treatment of Neonatal Abstinence Syndrome at a Tertiary Children's Hospital
Authors: Celestin Gregorey , Balding Meagan , Para Jenna L. , Utley Aubrey , Shaddix Brittany Powers 
Published: November 2022

OBJECTIVE
Lack of a standardized opioid wean guideline for the treatment of neonatal abstinence syndrome (NAS) has the potential to increase the length of the wean and subsequently the length of stay for neonates in the neonatal intensive care unit (NICU). The purpose of this study was to assess the effect of a pharmacist-driven methadone stewardship program for NAS treatment.

METHODS
The NAS stewardship program consisted of provider, pharmacist, and nursing education, a pharmacy surveillance system rule, and an updated clinical practice guideline. The pre- and post-intervention period were defined as patients admitted to the NICU from July 2019–October 2019 and August 2020–November 2020, respectively. The primary objective was to assess the effect of the stewardship program on the duration of opioid treatment in days. Secondary outcomes included number of dose titrations and length of hospital stay.

RESULTS
A total of 21 patients were included in this study. Neonates treated following the adoption of the stewardship program (n = 8) experienced a 34% decreased median duration of treatment (29 days vs 19 days; p = 0.84). Secondary endpoints of median number of titrations and length of stay were decreased by 15% (1.5 titrations; p = 0.52) and 24% (8 days; p = 0.85), respectively, leading to an average cost savings of $60,020 per patient.

CONCLUSIONS
Implementation of a standardized stewardship guideline for treatment of NAS resulted in a favorable decrease in all considered endpoints. Implications of the study further support the need for more evidence-based standardized guidelines for optimal treatment of patients with NAS.
Wooden Panel Inscribed for Amasis
Authors: Bianchi Robert Steven 
Published: November 2022

A wooden, openwork panel inscribed for Amasis and embellished with secondary glass inlays and gilding was disco- vered in 2018 by the Franco-Swiss Archaeological Mission at South Saqqara in a disturbed, archaeological context littered with bovine skeletal remains in the southern section of the pyramid complex of queen Ankhnespepy II. The panel’s openwork design finds its closest parallels in two-dimensional representations of funerary furnishing that suggest that this particular object formed part of the panoply of a sacred animal, suggested to have been a bull, the cults of which were supported by Amasis at Saqqara. Those comparisons call into question the function of all of the wooden panels embellished with glass inlays dated to the Late Period (given in Appendix) and whether the term, naos, is an appropriate designation for all such objects.

تم اكتشاف لوحة خشبية مخرمة منقوشة لأمازيس مزينة بتطعيمات زجاجية ومذهبة في عام 2018 من قبل البعثة الأثرية الفرنسية- السويسرية في جنوب سقارة في سياق أثري مضطرب مليء ببقايا الهياكل العظمية البقرية في القسم الجنوبي من مجمع هرم الملكة عنخ-نس- بيبي الثانية. يعد تصميم اللوحة المخرمة قريب من التمثيلات ثنائية الأبعاد للأثاث الجنائزي التي تشير إلى أن هذه اللوحة كانت تشكل جز ًءا من لوحة حيوان مقدس، يُقترح أنه كان ثو ًرا، وهي الطائفة التي دعمها أمازيس في سقارة. هذه المقارنات تثير التساؤل حول وظيفة جميع الألواح الخشبية المزخرفة بتطعيمات زجاجية التي تعود إلى العصر المتأخر (الواردة في الملحق) وما إذا كان المصطلح ناووس هو تسمية مناسبة
لجميع هذه القطع.
Finding the Village
Authors: Ghabriel Ikram , Quirke Stephen 
Published: November 2022

Historians and archaeologists tend to detach sites and objects in urban and rural settings from the people living there, as neglected treasures awaiting recognition and rescue by an outsider. In this paper, we consider the range of persons and institutions involved in accumulating material evidence for the Ramesside artists who worked on the tombs in the Valley of the Kings and lived in a village between the Theban desert cliffs and the fields. A first wave of extracting their monuments, in the late 1810s, offers an opportunity to investigate the processes involved in collecting antiqui- ties, and the relations between the protagonists—local, international, and intermediary. We argue that a focus on questions of historical method and sources would increase precision on statements of provenance in collections and help to align a more self-critical history of archaeology with the primary aim of others to understand a past society.

لقد اعتاد المؤرخون والاثريون على فصل المواقع الاثرية والقطع المكتشفة بها سواء بالريف او الحضر عن سكان هذه المناطق كما اعتادوا على تصوير هذه المواقع والقطع الاثرية بأنها كنوز مهملة عادة ما تحتاج إلى شخص من خارج هذه المناطق لتقديرها وانقاذها. تتناول هذه المقالة دراسة للأشخاص والمؤسسات التي قامت بتكوين مجموعات من آثار فناني عصر الرعامسة. هؤلاء الفنانون الذين عملوا بمقابر وادي الملوك وسكنوا بمدينة تقع بين تلال صحراء طيبة والحقول الزراعية. وتقدم لنا دراسة أولى عمليات تمت بهدف التنقيب عن آثار هؤلاء الفنانين بنهاية عام 1810 مثال لفهم أساليب تكوين مجموعات الآثار المصرية وما تتضمنه هذه الأساليب من علاقات مختلفة بين مستفيدين محليين وعالميين وما بينهما من وسطاء. وتسلط هذه المقالة الضوء على كيفية استخدام الأدلة التاريخية وطرق البحث المستخدمة في علم التأريخ لمعرفة أماكن اكتشاف المجموعات الاثرية على نحو أكثر دقة وتساعدنا هذه الدراسة على تقديم رؤية نقدية لنشأة وتاريخ علم الآثار المصرية مما يجعل
فهم المجتمعات القديمة من أولويات البحث في علم الآثار.
Keeping It in the Family
Authors: Green Gemma F. P. 
Published: November 2022

The first half of Egypt’s Fifth Dynasty saw a number of administrative and ideological changes. For the first time, officials of non-royal descent were able to hold positions within the higher levels of the administration, and Re became an integral part of the dogma of divine kingship. These occurrences may have caused some concern for the king, who seems to have taken profound measures to ensure that both his administration and Re’s powerful priesthood remained under his control. The titulary of two successive officials, Seshathetep [G 5150] and Kanefer [Dahshur no. 28, EA 1324 and EA 1345], demonstrate that the vizierate and the High Priesthood of Re were held by the same royal official for much of the Fifth Dynasty. The concentration of these two titles into the hands of the same individual is previously unattested and may indicate some apprehension about the dispersion of these titles amongst the non-royal administration, and perhaps the need to keep the Re cult under the king’s watchful eye. Using blood ties to ensure that these officials were loyal, trustworthy and reliable may have created a much-needed sense of security for the king, who may have been unsure about the integrity of his newly appointed court.

شهدالنصفالأولمنالأسرةالخامسةفيمصرالقديمةعدًدامنالتغييراتالإداريةوالعقائدية.وتمكنالمسؤولونلأولمرةمنأصلغير ملكي من شغل مناصب إدارية عليا، وأصبح رع جز ًءا لا يتجزأ من عقيدة الملكية الإلهية. ربما تسببت هذه الأحداث في بعض القلق للملك، الذي يبدو أنه اتخذ إجراءات حاسمة لضمان بقاء إدارته وكهنة رع الأقوياء تحت سيطرته. يُظهر اللقب الخاص باثنين من المسؤولين المتعاقبين، سشات-حيب ]5150 G[ وكا-نفر ]1324 EA و1345 EA[، أن منصب الوزير والكهنوت الأعلى للإله رع كانا تحت حكم نفس المسؤول الملكي في معظم فترة الأسرة الخامسة. إن تركيز هذين المنصبين في أيدي نفس الشخص لم يتم التحقق منه من قبل وقد يشير إلى بعض التخوف من تشتت هذه الألقاب بين الإدارة الغير ملكية، وربما الحاجة إلى إبقاء عبادة رع تحت سيطرة الملك. ومن الممكن أن استخدام الصلات العائلية للتأكدمنإخلاصوولاءالمسؤولينوأنهمجديرينبالثقةويمكنالاعتمادعليهمقدخلقإحساًسابالأمنللملك،والذيربماكانغيرمتأكدمن
نزاهة أفراد البلاط الملكي الذي تم تعيينه حديثًا.
Fourth Report on the Publication and Conservation of the Tomb of Ramesses III in the Valley of the Kings (KV 11)
Authors: Weber Anke , Dietze Klara , Popko Lutz , Rees Gareth , Schwarz Sandro 
Published: November 2022

The following article presents preliminary results of a sondage in the burial chamber (hall J) and a visual survey in the areas H, I, J, Ja-Jd, K1, K2, and L during the 2019/2020 field season carried out by The Ramesses III (KV 11) Publication and Conservation Project in the tomb of pharaoh Ramesses III.1 The detailed description and interpretation of the initial excavation work were omitted from the Second Report2 because it required more extensive discussion. The authors present their archaeological field work, their research, and the systematic examination of finds. Several unexpected finds shed new light on the use and reuse of KV 11. A sondage in the burial chamber provides insight into ancient and modern activities within the tomb. Additionally, more information is presented on photogrammetry in KV 11 as well as a provisional sketch of a site management plan centered on the digitization of a visitors’ itinerary. The work was carried out under the supervision of the Egyptian Ministry of Tourism and Antiquities with support by Ahmed Hussein Youssef Mohamed and our Egyptian workmen.
الملخصيعرض المقال التالي النتائج الاولية للمجس في حجرة الدفن (حجرة J) والمسح البصري في المناطق H و I و J و Jd-Ja و K1 و K2 و L خلال
الموسم الميداني 2020/2019 الذي نفذه مشروع رمسيس الثالث (KV11) للنشر والحفظ في مقبرة رمسيس الثالث.3 تم حذف الوصف

التفصيلي والتفسير لأعمال الحفر الأولية من التقرير الثاني4 لأنها تتطلب مناقشة أكثر شمولاً. يقدم الباحثون عملهم الميداني الأثري، وأبحاثهم، والفحصالمنهجيللاكتشافات.تلقيالعديدمنالاكتشافاتالغيرالمتوقعةضوًءاجديًداعلىاستخداموإعادةاستخداممقبرةKV11.وفر المجس الذي تم في حجرة الدفن نظرة ثاقبة للأنشطة القديمة والحديثة داخل المقبرة. بالإضافة إلى ذلك، يتم تقديم المزيد من المعلومات حول القياس التصويري للمقبرة KV11 بالإضافة إلى رسم تخطيطي مؤقت لخطة إدارة الموقع التي تركز على رقمنة خط سير الزائر. تم تنفيذ العمل
تحت إشراف وزارة السياحة والآثار المصرية بدعم من أحمد حسين يوسف محمد وعمالنا المصريين.
Conservation genomics of Agave tequilana Weber var. azul: low genetic differentiation and heterozygote excess in the tequila agave from Jalisco, Mexico
Authors: Ruiz Mondragon Karen Yazmin , Aguirre-Planter Erika , Gasca-Pineda Jaime , Klimova Anastasia , Trejo-Salazar Roberto-Emiliano , Reyes Guerra Marco Antonio , Medellin Rodrigo A. , Piñero Daniel , Lira Rafael , Eguiarte Luis E. 
Published: November 2022

Background
Genetic diversity is fundamental for the survival of species. In particular, in a climate change scenario, it is crucial that populations maintain genetic diversity so they can adapt to novel environmental conditions. Genetic diversity in wild agaves is usually high, with low genetic differentiation among populations, in part maintained by the agave pollinators such as the nectarivorous bats. In cultivated agaves, patterns of genetic diversity vary according to the intensity of use, management, and domestication stage. In Agave tequilana Weber var. azul (A. tequilana thereafter), the plant used for tequila production, clonal propagation has been strongly encouraged. These practices may lead to a reduction in genetic diversity.

Methods
We studied the diversity patterns with genome-wide SNPs, using restriction site associated DNA sequencing in cultivated samples of A. tequilana from three sites of Jalisco, Mexico. For one locality, seeds were collected and germinated in a greenhouse. We compared the genomic diversity, levels of inbreeding, genetic differentiation, and connectivity among studied sites and between adults and juvenile plants.

Results
Agave tequilana presented a genomic diversity of HT = 0.12. The observed heterozygosity was higher than the expected heterozygosity. Adults were more heterozygous than juveniles. This could be a consequence of heterosis or hybrid vigor. We found a shallow genetic structure (average paired FST = 0.0044). In the analysis of recent gene flow, we estimated an average migration rate among the different populations of m = 0.25. In particular, we found a population that was the primary source of gene flow and had greater genomic diversity (HE and HO), so we propose that this population should continue to be monitored as a potential genetic reservoir.

Discussion
Our results may be the consequence of more traditional management in the studied specific region of Jalisco. Also, the exchange of seeds or propagules by producers and the existence of gene flow due to occasional sexual reproduction may play an important role in maintaining diversity in A. tequilana. For populations to resist pests, to continue evolving and reduce their risk of extinction under a climate change scenario, it is necessary to maintain genetic diversity. Under this premise we encourage to continue acting in conservation programs for this species and its pollinators.
Formulation of a Flavored Drink Based on Sapodilla Puree, Pineapple Juice and Lemongrass Essential Oil
Authors: Konfo Christian T. R. , Aïssi M. Vahid , Koudoro Yaya A. , Bocoga Gérard M. , Dahouénon-Ahoussi Edwige , Sohounhloué Dominique C. K. 
Published: November 2022

Aims: Neglected or underutilized plant species, such as sapodilla (Manilkara zapota), which play a substantial role in the livelihoods of populations but whose potential remains still under-exploited, deserve particular attention from researchers to a better knowledge of its food applications. This study aims to develop a novel drink based on sapodilla fruit and other known ingredients with acceptable sensory, microbiological and physicochemical characteristics.
Place and Duration of Study: The study was carried out at Ecole des Sciences et Techniques de Conservation et de Transformation des Produits Agricoles of the Université Nationale d'Agriculture (UNA) in Benin between June and September 2021.
Methodology: Flavored beverages with the essential oil of Cymbopogon citratus were formulated from sapodilla puree and pineapple juice following a mixing plan. The microbiological, organoleptic and physicochemical analyzes of formulated cocktail were then carried out by standard methods.
Results: All the formulated drinks presented a satisfactory microbiological quality. The E5 formula containing 10% of the sapodilla puree and 90% of the juice of pineapple and the essential oil of C. citratus was the most accepted by tasters. This beverage had a pH of 5.46±0.06, a total soluble solid of 17.25±0.35 ºBrix and a specific gravity of 1.08±0.01. The titratable acidity, total ash and dry matter content were 0.80±0.01 g/100g, 0.19±00% and 15.28±1.07 respectively.
Conclusion: The fruit of sapodilla can be valued through good quality drinks which can be popularized after a nutritional characterization.
Association of Residential Racial and Economic Segregation With Cancer Mortality in the US
Authors: Zhang Lu , Gong Rui , Shi Lu , Wen Ming , Sun Xiaoqian , Yabroff K. Robin , Han Xuesong 
Published: November 2022

ImportanceResidential segregation is a structural risk factor for poor cancer outcomes. Previous research examining the association of residential segregation with cancer outcomes was limited by older data, restricted geographic areas, and few cancer sites. To guide targeted interventions, a comprehensive evaluation of the association between segregation and cancer outcomes is needed.ObjectiveTo examine the association of residential racial and economic segregation with cancer mortality at the US county level for all cancers combined and for the 13 cancer types that represent the top 10 causes of cancer deaths in males or females.Design, Setting, and ParticipantsThis ecological study used county-level sociodemographic data from the 2015-2019 American Community Survey linked with 2015-2019 county-level mortality data. Data analysis was performed from September 2021 to April 2022.ExposuresResidential racial and economic segregation measured by the Index of Concentration at the Extremes (ICE) and categorized into quintiles 1 (most deprived) through 5 (most privileged).Main Outcomes and MeasuresAge-adjusted cancer mortality was the outcome. Multilevel linear mixed modeling was used to calculate the adjusted mortality rate ratio (aRR).ResultsA total of 3110 counties were included. The age-adjusted mortality rates of all cancers combined were 179.8, 177.3, 167.6, 159.6, and 146.1 per 100 000 population (P &amp;lt; .001 for trend) for the 5 ICE categories (most deprived to least deprived), respectively. Compared with the least deprived counties, aRRs for all cancers combined were 1.22 (95% CI, 1.20-1.24) for the most deprived counties, followed by 1.17 (95% CI, 1.15-1.19), 1.10 (95% CI, 1.09-1.12), and 1.06 (95% CI, 1.04-1.08) for the other 3 quintiles, respectively (P &amp;lt; .001 for trend). Segregation was associated with increased mortality from 12 of 13 selected cancer sites, in which aRRs ranged from 1.06 (95% CI, 1.02-1.09) for brain and other nervous system cancer to 1.49 (95% CI, 1.43-1.54) for lung and bronchus cancer.Conclusions and RelevanceThe findings of this ecological study suggest that residential racial and economic segregation is associated with higher cancer mortality at the county level, highlighting opportunities for geographically targeted cancer prevention and control efforts.