bluuebunny/crossref_metadata_2025_split huggingface dataset:
An effective LRTC model integrated with total α‐order variation and boundary adjustment for multichannel visual data inpainting
Authors: Yang Xiuhong , Xue Yi , Lv Zhiyong , Jin Haiyan 
Published: July 2022

AbstractRestoring damaged multichannel visual data with high loss ratio is quite a challenging task. To address this problem, an effective LRTC (low‐rank tensor completion) model integrated with total α‐order variation (TVα) in the fractional bounded variation space BVα is proposed to perform superior fractional‐in‐space regularization. Based on using LR constraint to restore global patterns, TVα regularization is integrated to exploit nonlocally‐correlated information on each channel to infer the lost data and simultaneously effectively deal with complex details due to the powerful fractional calculus. Then, a nonlocal fractional regularization strategy for multi‐dimensional data and an effective numerical optimization method are creatively designed to solve this problem. Two novel fractional derivative matrix approximations are derived and applied to the first two unfolding modes of the tensor respectively to conveniently solve the fractional regularization subproblem by using an element‐wise shrinkage‐thresholding operation. In addition, boundary extension and adjustment strategy are designed for the unfolded matrices to alleviate the influence of inaccurate boundary conditions in fractional derivative computations. Experiments are conducted to illustrate its performance and efficiency for YUV video, RGB and HSI restoration, especially its ability to effectively recover complex structures and the details of multi‐component visual data with relatively high missing rate.
The impact of ride‐hailing services on the use of traditional taxis: Evidence from Chinese urban panel data
Authors: Zhong Jun , Zhou Huan , Lin Yan , Ren Fangxiao 
Published: July 2022

AbstractCurrently, opinions on whether and how ride‐hailing services have impacted the use of traditional taxis are divided, and no consensus has been reached. This paper used panel data from 44 cities in China from 2010 to 2016 to estimate the impact of ride‐hailing services on the use of traditional taxis by applying the multiperiod difference‐in‐difference (multiperiod DID) method and conducting a series of robustness tests. The results show that ride‐hailing services have a large, negative impact on the use of traditional taxis, and this negative impact is more severe in eastern cities. These results suggest that in China it is necessary for traditional taxi operators to make changes and innovations to become more sustainable in response to pressure from ride‐hailing services. Additionally, it is suggested that city governments in China pay greater attention to the impact of emerging ride‐hailing services on traditional taxi services, embrace emerging modes of mobility, and create appropriate policies to coordinate the development of both new and traditional services.
Diagnostik erhöhter Leberwerte in der Primärversorgung – Befunde einer Studienreihe aus haus- und fachärztlicher Perspektive
Authors: Wangler Julian , Jansky Michael 
Published: July 2022

Zusammenfassung
Hintergrund In der Primärversorgung treten Leberwerterhöhungen häufig als Zufallsbefund in Erscheinung. Neben der Beachtung von Symptomen ist für eine effektive Abklärung entscheidend, welche Leberwerte als Indikatoren einbezogen und wann Patient*innen zur weiterführenden Diagnostik überwiesen werden. Ebenso kommt es auf eine geregelte Zusammenarbeit zwischen haus- und fachärztlicher Versorgungsebene an. Bislang fehlt es für den deutschsprachigen Raum an belastbaren Erkenntnissen über den Status quo hinsichtlich der Abklärung (unklarer) Leberwerterhöhungen im niedergelassenen und hausärztlichen Bereich. Der Überblicksartikel komprimiert die Bilanz einer explorativen Studienreihe, deren Ziel darin bestand, eine Bestandsaufnahme hinsichtlich des Status quo der hausarztbasierten Diagnostik (unklar) erhöhter Leberwerte zu leisten. Aus den Ergebnissen werden Ansatzpunkte einer Optimierung abgeleitet.
Methodik Zwischen 2017 und 2021 wurden 4 schriftliche Befragungen von Hausärzt*innen und gastroenterologischen Fachärzt*innen in verschiedenen Bundesländern durchgeführt. Die vorliegende Studienbilanz diskutiert die Gesamtbefunde komprimiert auf übergeordneter Ebene, geht jedoch auch auf spezifische Befunde ein.
Ergebnisse Mit Blick auf Abklärung erhöhter Leberwerte zeigen sich diverse Herausforderungen und Problematiken. So ziehen Hausärzt*innen stark unterschiedliche Laborparameter heran (95% γ-GT, 65% AST, 63% ALT), die sich in verschiedenen Clustern bündeln. Im Fall erhöhter Leberwerte präferiert eine Mehrheit der Hausärzt*innen ein kontrolliertes Zuwarten (66%), macht allerdings im Alltag oft aufgrund von diagnostischen Unsicherheiten von direkten Überweisungen zu Spezialist*innen Gebrauch (40%). In der Zusammenarbeit mit gastroenterologischen Fachärzt*innen bestehen aus hausärztlicher Sicht Schnittstellenprobleme, die u.a. mit der im Vorfeld geleisteten Abklärung sowie dem Überweisungszeitpunkt einhergehen. Sowohl Haus- als auch Fachärzt*innen erachten die Einführung eines evidenzbasierten Diagnosealgorithmus als wichtigen Ansatz für die Verbesserung der Früherkennung sowie eine bessere Koordination zwischen den Versorgungsebenen (80% bzw. 85%).
Diskussion Es sollte darauf hingewirkt werden, zu einer stärkeren Professionalisierung und Vereinheitlichung der primärärztlichen Diagnostik beizutragen und die Zusammenarbeit mit gastroenterologischen Spezialisten besser zu strukturieren. Dazu zählen ein breiteres Angebot von Fortbildungsformaten, die Entwicklung eines validierten Diagnosepfads und die feste Verankerung einer leberwertassoziierten Blutuntersuchung im Rahmen des Check-ups. Auch die Entwicklung einer hausarztbasierten Leitlinie zum Umgang mit erhöhten Leberwerten erscheint ratsam.
Gender Affirmative Care Clinic: An Overview
Authors: Sharma Sanjay , Sharma Bela 
Published: July 2022

AbstractTransgender healthcare is an evolving multispecialty field including medical and social domains catering to the needs of a specific subset of population presenting with gender incongruence, differences in sexual development/orientation, requiring care rather than cure. Delivery of transgender healthcare is done through gender friendly healthcare facilities, which are designated as “gender affirmative care clinics (GACC).” The primary purpose of the gender affirmative care clinic is to be the “one stop solution” for a person seeking affirmative care. The main objective is to facilitate care with compassion and prevent/mitigate dysphoria. The components of the GACC should include reception cum front office; affirmative mental healthcare department; affirmative medical, surgical, and sexual healthcare department; diagnostics, legal, and ethics department, as well as inpatient care. The GACC should be preferably located in a place that is easily accessible to the community members and has an “open plan.”
Estudo observacional prospectivo sobre os desfechos da descompressão posterior e fixação em estágio único na tuberculose da coluna dorsolombar
Authors: Menon Hari J. , Tripathi Aditya V. , Patel Nrutik M. , Narang Chandan 
Published: July 2022

Resumo
Objetivo Estudar os desfechos da descompressão posterior isolada e instrumentação na tuberculose da coluna dorsal e dorsolombar.
Métodos Os pacientes (n = 30) incluídos neste estudo apresentavam tuberculose na coluna dorsal ou dorsolombar, acompanhada ou não por déficit neurológico e/ou deformidade. Todos os 30 pacientes foram tratados apenas por descompressão posterior e instrumentação. Estudamos a correção e manutenção da deformidade na coluna dorsal e dorsolombar, o desfecho funcional segundo o índice de deficiência de Oswestry (ODI) e a escala visual analógica (EVA); o desfecho neurológico foi estudado de acordo com a classificação de Frankel.
Resultados Na atual série, 30 pacientes foram submetidos à descompressão posterior e instrumentação em estágio único e apresentaram melhora significativa no estado neurológico e desfecho funcional segundo os scores de ODI, EVA e classificação de Frankel.
Conclusão A abordagem posterior (extracavitária) permite o acesso ideal aos aspectos laterais e anteriores da medula espinhal para uma boa descompressão. Facilita a mobilização precoce, evita problemas associados ao decúbito prolongado, proporciona melhor desfecho funcional e corrige a cifose no plano sagital de maneira significativamente melhor.
A Biomechanical Comparison of Fixation Techniques in Metacarpal Shaft Fractures
Authors: Albanese Kevin M. , Schreck Michael J. , Werner Frederick W. , Esper Garrett W. , Ordway Nathaniel R. 
Published: July 2022

Abstract
Background Typically, metacarpal shaft fractures are treated with closed reduction percutaneous pinning, intramedullary nails, or plate fixation. Recently some surgeons have begun using intramedullary headless compression screws.
Questions/Purposes The purpose of this study was to compare intramedullary screw fixation to K-wire fixation, which is the standard of care in a transverse metacarpal midshaft fracture, using a cadaveric model. Our hypothesis was that intramedullary screw fixation would have a biomechanical advantage (higher stiffness and peak load to failure) when compared with dual Kirschner wire fixation of transverse metacarpal shaft fractures.
Methods Four-point bend testing was performed to compare stiffness and failure load values of seven paired 2nd and 3rd metacarpals instrumented with headless intramedullary compression screw fixation or Kirschner wire fixation. Similar testing was performed on 14 unpaired 4th metacarpals.
Results There was no significant difference in peak load (p = 0.60) or stiffness (p = 0.85) between fixation groups for the 2nd and 3rd instrumented metacarpals. For the instrumented 4th metacarpals, there was no significant difference in peak load (p = 0.14), but the stiffness was significantly greater (p = 0.01) for the compression screw group compared with the Kirschner wire fixation.
Conclusions/Clinical Relevance In this study, the load to failure was not different between the two fixation methods and likely both techniques can sustain physiologic loads needed for rehabilitation. The greater stiffness in the 4th metacarpal compression screw group may be related to the smaller canal morphology than in the 2nd and 3rd metacarpals. Larger diameter screws may be needed to obtain a better fit particularly in the 2nd and 3rd metacarpals.
Prevalence and Pattern of Congenital Heart Disease in Pediatric Population—A Study from Central India
Authors: Jain Pradeep Kumar , Lazarus Monica , Tiwari Asha , Athwani Vivek Kumar 
Published: July 2022

AbstractIntroduction Prevalence of congenital heart disease (CHD) is variable depending on the region and setting of study ranging from 0.8 to 6/1,000. Age of presentation depends on types of CHD and its severity. Burden of CHD is not known in this tribal belt of Central India. Main objective of this study was to find out prevalence of CHD in children. We have also studied the pattern and age of presentation of various types of CHDs.Methods This retrospective observational study was conducted at tertiary care teaching institute in tribal belt of Central India. Children aged 0 to 15 years reported to pediatric outpatient department (OPD) were included. CHD was confirmed by echocardiography in suspected cases. Prevalence rate was calculated as number of CHDs per 1,000 OPD patients. Pattern of CHD was categorized as per standard guidelines and age-wise presentations of various types of CHD were studied.Results The prevalence rate of CHD in our study population was 27.7/1,000, which is high when compared with most of the other hospital-based studies. Most of the patients, 60.36 and 83.26% were detected before the age of 1 year and 5 years, respectively. All critical CHD cases were detected in early infancy.Conclusion There is a high burden of CHD seen in this study. Possible cause of this may be lack of specialized facility in this reason and study period included first and second wave of COVID. Further, large sample size studies and/or nationwide registry/database are needed to know the exact burden of CHD.
Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides
Authors: Wang Dali , Wang Qiwei , Wang Yuyan , Chen Peiru , Lu Xueguang , Jia Fei , Sun Yehui , Sun Tingyu , Zhang Lei , Che Fangyuan , He Jialu , Lian Liming , Morano Gemma , Shen Michael , Ren Mengqi , Dong Sijia S. , Zhao Jean J. , Zhang Ke 
Published: July 2022

The mutant form of the guanosine triphosphatase (GTPase) KRAS is a key driver in human tumors but remains a challenging therapeutic target, making

KRAS
MUT

cancers a highly unmet clinical need. Here, we report a class of bottlebrush polyethylene glycol (PEG)–conjugated antisense oligonucleotides (ASOs) for potent in vivo KRAS depletion. Owing to their highly branched architecture, these molecular nanoconstructs suppress nearly all side effects associated with DNA–protein interactions and substantially enhance the pharmacological properties of the ASO, such as plasma pharmacokinetics and tumor uptake. Systemic delivery to mice bearing human non–small-cell lung carcinoma xenografts results in a significant reduction in both KRAS levels and tumor growth, and the antitumor performance well exceeds that of current popular ASO paradigms, such as chemically modified oligonucleotides and PEGylation using linear or slightly branched PEG. Importantly, these conjugates relax the requirement on the ASO chemistry, allowing unmodified, natural phosphodiester ASOs to achieve efficacy comparable to that of chemically modified ones. Both the bottlebrush polymer and its ASO conjugates appear to be safe and well tolerated in mice. Together, these data indicate that the molecular brush–ASO conjugate is a promising therapeutic platform for the treatment of
KRAS
-driven human cancers and warrant further preclinical and clinical development.
Pronoun TA as a facilitator of empathy in Chinese digital narratives
Authors: Sluchinski Kerry 
Published: July 2022

Abstract
This article presents findings pertaining to digital you-narratives in which ungendered third person Chinese
pronoun ta is embedded. The study asks what implications the script choice ta, as opposed to gendered
他 ta ‘he’ and 她 ta ‘she’, has for the facilitation of
situational empathy when used in conjunction with specific and generic 你 ni ‘you’. The study draws on 131 digital texts from celebrity verified accounts on
social media platform Sina Weibo in October 2015. From a Discourse Analytical perspective, the study utilizes pragmatic and
textual approaches under a constructivist narrative analysis framework to examine the facilitative role of ta in relation to
empathy invoked in readers. The study proposes that ta is a pragmatic resource used to facilitate the
co-construction of emergent narratives based on situational empathy. The implications of said findings are discussed along with
future avenues of research.
Dynamic imaging comparison of 18F-FDG tracers with Compton imaging and PET coincidence imaging
Authors: Kim D. , Shimazoe K. , Uenomachi M. , Takahashi H. 
Published: July 2022

Abstract
In the clinical situation of positron emission tomography (PET) scans, an activity of an approximately few hundred megabecquerels (3.7 MBq/kg) is used for injection. Monitoring and imaging of moving radioisotopes is useful in clinical applications, such as tracer injection and leakage monitoring in PET scan protocols. We have developed a Compton imaging and PET coincidence system to monitor a moving radioisotope using 8 × 8 GAGG crystal arrays coupled to SiPM arrays with dynamic time-over-threshold-based individual readout circuits, and its imaging performance is considered. The measured resolution of PET and Compton imaging is 3.2 mm and approximately 17 degrees for a 22Na point source. In the experiment, radiotracers with activities from 11.2 MBq to 93.3 MBq moving with speeds from 1 mm/s to 10 mm/s were used for mimicking the blood flow. Both reconstructed images of PET and Compton imaging successfully visualized the movement, except for Compton imaging in the 93.3 MBq case. PET shows better activity-tracking capability and radio-tracer speeds up to 100 MBq. In contrast, Compton imaging has a wider field of view (FOV) to monitor a larger area than the limited FOV in a PET system. We believe that this work can contribute to solutions of various medical problems such as blood flow measurement and extravasation detection.
Calcium and phosphorus co-doped carbon dots enhance osteogenic differentiation for calvarial defect repair in situ
Authors: Wu Lin , Wu Yunchao , Jingjin Liu , Liu Suwan , Li Qianzhe , Yang Mengyu , Zhang Miaomiao , Ji Qing , Zhang Feimin , Du Fengyi 
Published: July 2022

Abstract
Calvarial bone defect remains a clinical challenge due to the lack of efficient osteo-inductive agent. Herein, a novel calcium and phosphorus codoped carbon dot (Ca/P-CD) for bone regeneration was synthesized using phosphoethanolamine and calcium gluconate as precursors. The resultant Ca/P-CDs exhibited ultra-small size, stable excitation dependent emission spectra and favorable dispersibility in water. Moreover, Ca/P-CDs with good biocompatibility rapidly entered the cytoplasm through endocytosis and increased the expression of bone differentiation genes. After mixing with temperature-sensitive hydrogel, Ca/P-CDs were injected in situ into calvarial defect and promoted the repair of bone injury. These Ca/P-CDs provide a new treatment method for the bone repair and should be expended the application in the biomedical fields.
Speeding extreme cold events under global warming
Authors: Guan Xiaodan , Gao Zhaokui , Huang Jianping , Cao Chenyu , Zhu Kaiwei , Wang Jiamin 
Published: July 2022

Abstract
Regional anthropogenic warming caused stronger and shorter cold events in the winter (December–February) of 2020–21, with the strongest cooling of −10 °C covering an area of 1.63 × 107 km2 over East Asia. In contrast to previous cold events, the extreme cold events in 2020–21 were a result of meridional circulation change due to stronger regional anthropogenic warming. Our results show a multi-aspect anthropogenic effect in the process of cold events, and illustrate that anthropogenic effect played a role not only in the thermodynamic process but also in the dynamic process. The exchange of equilibrium from low to high index does not take fewer cold events anymore; new principles on equilibrium have appeared and will soon play an effect in more fields of climate change.
Evaluating the scaling potential of sustainable land management projects in the Sahelian Great Green Wall countries
Authors: Mechiche-Alami Altaaf , O’Byrne David , Tengberg Anna , Olsson Lennart 
Published: July 2022

Abstract
The Great Green Wall (GGW) Initiative aims at combatting land degradation while achieving socio-economic development across the Sahel through a mosaic of sustainable land management (SLM) and restoration practices. As the Global Environment Facility (GEF) is the main funding mechanism for land degradation neutrality related projects, we have analyzed its previous SLM projects in four pilot countries in an effort to assess their capacity to foster scaling of interventions and fast track progress towards the GGW objectives. We developed a literature-based scaling evaluation framework and scoring methods to harmonize the GEF agency based project ratings in terms of performance and persistence along seven evaluation domains. We found that projects perform better over time particularly in terms of monitoring, financing and resilience to shocks but are overall only moderately likely to achieve benefits persistent over time, which is necessary to allow for the scaling of interventions. While these efforts should be maintained and further pursued, we also recommend special attention to be placed on a number of interventions that are often less successful or ignored by projects such as enforcing mechanisms for new SLM regulations, empowering vulnerable groups and ensuring sufficient capacity and finances for sustaining achievements even during periods of political or climatic instability.
Optimization and effect of B4C/Al2O3 with graphite particulates on tribological properties of Al7075 surface hybrid nanocomposite
Authors: Gobikannan S , Gopalakannan S , Balasubramanian P 
Published: July 2022

Abstract
Aluminium alloy surface hybrid nanocomposite, reinforced with boron carbide (B4C), aluminium oxide (Al2O3), and Graphite (Gr) at different combination mixtures by weight ratio have been fabricated on Al7075-T6 aluminium plate by employing friction stir processing (FSP). The mixtures of definite proportions were packed in an array of blind holes 2.5 mm in diameter and 3 mm deep which are 6 mm apart from each other. FSP was done with processing factors of 750 rpm revolving speed, 20 mm min−1 feed, and tool angle of 3°. The prepared hybrid composites were sectioned for microstructure, macrostructure, wear, and hardness evaluation. In the metal matrix surface composite, the scanning electron microscope (SEM) and field emission scanning electron microscope (FESEM) depict the homogeneity in the distribution of reinforcement elements, microstructure, and wear behaviour. Under dry sliding conditions, the nanocomposite’s wear behaviour was investigated by adopting a central composite design (CCD) at 3 levels in response surface methodology (RSM) for optimization. The wear characteristics are analyzed using pin on disc apparatus. The wear property of the nanocomposites with distinct reinforcement ratios was evaluated. Higher hardness values (maximum of 191 Hv) were found in hybrid nanocomposite samples than in the plain FSPed samples (149Hv) without reinforcement. It is evident, that the wear loss depends on the relative weight ratio of B4C and Al2O3 with a constant amount of graphite and the minimum wear loss of 2.9421 mm3 is obtained from composite with 30 B4C + 60 Al2O3+10 Gr reinforcement ratio than the wear loss of 8.2292 mm3 obtained from plain FSPed composite. The optimal combination of parameters, Al2O3 60%, load 20 N, and velocity 1 m s−1 was identified from RSM. The hybrid nanocomposite having a reinforcement mixture of 30 B4C + 60 Al2O3 + 10 Gr exhibits a significant wear resistance than other combination ratios. This is endorsed by the enhancement in binding strength of the matrix and the pinning effect of hard reinforcements, which act against the applied shear force.