bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient satisfaction with telemedicine in the Philippines during the COVID-19 pandemic: a mixed methods study
Authors: Noceda Alicia , Acierto Lianne Margot , Bertiz Morvenn Chaimek , Dionisio David Emmanuel , Laurito Chelsea Beatrice , Sanchez Girrard Alphonse , Amit Arianna Maever 
Published: July 2022

Abstract
Background: The capacity to deliver essential health services has been negatively impacted by the COVID-19 pandemic particularly due to lockdown restrictions. Telemedicine provides a safe, efficient, and effective solution that addresses the needs of patients and the health system. However, there remain implementation challenges and barriers to patient adoption in resource-limited settings as in the Philippines. This mixed methods study thus aimed to describe patient perspectives and experiences with telemedicine services, and explore the factors that influence telemedicine use and satisfaction.Methods: An online survey using Consumer Assessment of Healthcare Providers and Systems (CAHPS) Clinician & Group Adult Visit Survey 4.0 (beta) and Telehealth Usability Questionnaire (TUQ) was accomplished by 200 participants aged 18 to 65 years. A subsample of 16 participants was interviewed to provide insights to the quantitative data. We used descriptive statistics to analyze survey data and grounded theory to analyze data from interviews. Results: Participants were generally satisfied with telemedicine services, with most reporting that this was an efficient and convenient alternative to face-to-face consultations. However, only 2 in 5 perceived telemedicine as affordable. Our quantitative findings suggest that participants preferred telemedicine services rather than in-person consultations, especially in cases where they feel that their condition is not urgent and does not need extensive physical examination. Safety against COVID-19, and the availability of multiple communication platforms contributed to patient satisfaction with telemedicine. Negative perceptions of patients on their telemedicine provider, inherent limitations of telemedicine, perceived high costs, poor connectivity and other technological issues were found to be barriers to its use and satisfaction.Conclusion: Telemedicine is viewed as a safe and efficient alternative to receiving care. Continued adoption of telemedicine will require improvements in technology and better patient communication related to their telemedicine provider and the associated costs.
Association of Soluble Transferrin Receptor with Systolic Hypertension: Findings from the National Health and Nutrition Examination Survey (NHANES 2007–2010 and 2015–2018)
Authors: Wang Haoran , Qi Qianjin , Song Shuaihua , Zhang Di , Feng Li 
Published: July 2022

Abstract
Background
Hypertension increases the global burden of disease and mortality. Iron metabolism is considered to be an important factor in hypertension. However, as an indicator of iron metabolism, little is known about the associations of soluble transferrin receptor (sTfR) with hypertension. We studied the relationship between sTfR and hypertension.
Methods
We studied 7416 adults aged 20 years old or above from the National Health and Nutrition Examination Survey (NHANES), a nationally representative, cross-sectional, population-based study. Multiple logistic regression was used to examine the association between markers of iron metabolism and hypertension. We used the restricted cubic spline (RCS) to characterize the association between sTfR and blood pressure.
Results
Multiple logistic regression showed that higher sTfR level was associated with higher odds of hypertension (OR = 1.05; 95% CI: 1.01–1.05; P = 0.001) after adjustment for all the potential confounding factors. Meanwhile, logistic regression analyses indicated independent associations of high sTfR (P = 0.009) with systolic hypertension after adjusting for various different confounders. The result of restricted cubic splines showed a non-linear association between sTfR and systolic blood pressure was observed among U.S. adults.
Conclusions
sTfR was found to be an independent factor in systolic hypertension. Meanwhile, our research found a nonlinear relationship between sTfR and systolic blood pressure among U.S. adults.
The most promising social care practices for the elderly who are dependent and/or at risk of social exclusion in the Mediterranean basin: an integrative literature review
Authors: Porcel-Gálvez Ana María , Fadden Isotta Mac , Allende-Cussó Regina , Ferentinou Eleni , Zafiropoulou Maria , Lima-Serrano Marta 
Published: July 2022

Abstract
Objective The aim of this article was to describe the results of a literature review focused on identifying the social care practices, characteristics, and trends in each country participating in the TEC-MED European Project. The review also centred on the most promising initiatives directed towards the dependent elderly and/or those at risk of social exclusion in the Mediterranean Basin countries.Method The study was conducted in two phases to achieve both the integrative literature review goal and a qualitative research consensus among the research team based on the documents found in the literature. The integrative review identified 10,940 documents between 2000 and 2019. A total of 10,107 documents were found in the Scopus, Pubmed and Cochrane library official databases and 833 from other sources. The 20 most promising initiatives were selected from the 347 articles finally included.Results To be successful, the model of socio-ethical care for older people who are dependent and/or at risk of social exclusion must be based on person-centred integrative care and follow a holistic and interdisciplinary approach, paying special attention to bio-psycho-social frailty. The elements to consider are as follow: quality, research and dissemination, the gender perspective, ethics, social inclusion and transcultural issues.Conclusion The social practices in the Mediterranean Basin and the 20 most promising initiatives shared common aspects that served as a basis to design the TECMED model.
The Size and Behavior of Virtual Objects have influence on Functional Exercise and Motivation of Persons with Multiple Sclerosis: a randomized study
Authors: Cikajlo Imre , Hukić Alma , Pertot Anja Udovčić 
Published: July 2022

Abstract
Background: The consequences of multiple sclerosis are problems related to movement of extremities, coordination and vision. Heretofore frequent treatment with additional medications can change the course of the disease. Motor relearning of small range movements are important to support daily living activities. We have designed a virtual environment for pick and place task. The user hand and finger movements were tracked with a small infrared camera. The primary objective of the study was to examine the influence of size and behavior of virtual cubes on motor control, motivation and functional performance. The secondary objective was to examine the changes of heart rate and intensity of the task due to the different size and behavior of the virtual objects. Methods: In the randomized study 84/107 eligible inpatients with multiple sclerosis participated. They were randomized into 4 groups by computer random function; group 1 - small and bouncing, group 2 - small and non-bouncing, group 3 - big and bouncing and group 4 - big and non-bouncing virtual cubes. Each participant took 50 sessions, each up to 2 min in approximately 14 days. Before commencement of the study the participants took visual-spatial and cognitive tests. The participants’ subjective experiences was assessed daily with Intrinsic Motivation Inventory. Box and Blocks Test was carried out before and after the study. Results: In the study the group 4 was the most successful (inserted cubes > 9) and the fastest (63.4 SD 25.8 s). The group 1 was the slowest (88.9 SD 28.2 s), but with high interest/enjoyment rate and pressure/tension at high heart rate. There were substantial differences in intrinsic motivation between the 1st and the last session within the groups (Cohen's U3 < 0.3 or > 0.8). Kinematic analysis showed differences between the groups (average manipulation time p = 0.008, inserted cubes p = 0.004).Conclusions: The size and behavior of virtual objects may be crucial for the motivation of participants with equal visual-spatial and cognitive capabilities while maintaining effort and keep trying to improve their performance. Furthermore, the clinical outcomes can confirm the effectiveness of the approach.Trial registration: The small scale randomized pilot trial has been registered at ClinicalTrials.gov Identifier: NCT04266444, 12/02/2020, https://clinicaltrials.gov/ct2/show/NCT04266444
Development of an immune-related gene prognostic risk model and identification of an Immune infiltration signature in the tumor microenvironment of colon cancer
Authors: Hao Mengdi , Li Huimin , Yi Meng , Wang Kung , Liu Yin , Liang Xiaoqing , Ding Lei 
Published: July 2022

Abstract
Background: Colon cancer is a common and highly malignant tumor. Its incidence is increasing rapidly with poor prognosis. At present, immunotherapy is a rapidly developing treatment for colon cancer. The aim of this study was to construct a prognostic risk model based on immune genes for early diagnosis and accurate prognostic prediction of colon cancer.Methods: Transcriptome data and clinical data were downloaded from the cancer Genome Atlas database. Immunity genes were obtained from ImmPort database. The differentially expressed transcription factors (TFs) were obtained from Cistrome database. Differentially expressed (DE) immune genes were identified in 473 cases of colon cancer and 41 cases of normal adjacent tissues. An immune-related prognostic model of colon cancer was established and its clinical applicability was verified. Among 318 tumor-related transcription factors, differentially expressed transcription factors were finally obtained, and a regulatory network was constructed according to the up-down regulatory relationship.Results: A total of 477 DE immune genes (180 up-regulated and 297 down-regulated) were detected. We developed and validated twelve immune gene models for colon cancer, including SLC10A2, FABP4, FGF2, CCL28, IGKV1-6, IGLV6-57, ESM1, UCN, UTS2, VIP, IL1RL2, NGFR. The model was proved to be an independent prognostic variable with good prognostic ability. A total of 68 DE TFs (40 up-regulated and 23 down-regulated) were obtained. The regulation network between TF and immune genes was plotted by using TF as source node and immune genes as target node. In addition, Macrophage, Myeloid Dendritic cell and CD4+ T cell increased with the increase of risk score.Conclusions: We developed and validated twelve immune gene models for colon cancer, including SLC10A2, FABP4, FGF2, CCL28, IGKV1-6, IGLV6-57, ESM1, UCN, UTS2, VIP, IL1RL2, NGFR. This model can be used as a tool variable to predict the prognosis of colon cancer.
Does GLP-1 receptor agonist liraglutide alter food-related sensory pleasure in patients with obesity? A randomized controlled trial
Authors: Coppin Geraldine , David Muñoz Tord , Pool Eva , Locatelli Loïc , Achaibou Amal , Erdemli Asli , Perez Laura Leon , Wuensch Lavinia , Cereghetti Donato , Golay Alain , Sander David , Pataky Zoltan 
Published: July 2022

Abstract
Background/Objectives: Obesity is a complex condition and the mechanisms involved in weight gain and loss are poorly understood. Liraglutide, a GLP-1 receptor agonist, has been demonstrated to successfully promote weight loss in patients with obesity (OB). Yet, it is unclear whether the observed weight loss is driven by an alteration of food reward processing. Here we investigated the effects of liraglutide on cerebral correlates of food-related sensory pleasure in OB. Subjects/Methods: This study was a randomized, single-centre, double-blind, placebo-controlled, parallel group, prospective clinical trial. 73 patients with OB and without diabetes were randomly assigned (1:1) to receive liraglutide 3.0 mg (37.40±11.18 years old, BMI = 35.89 kg ±3.01) or placebo (40.04±14.10 years old, BMI = 34.88 kg ±2.87) subcutaneously once daily, for 16 weeks. They also followed a multidisciplinary weight loss program. Interventions/Methods: We investigated sensory pleasure during food consumption (i.e., “liking”). Participants reported their hedonic experience while consuming a high-calorie food (milkshake) and a tasteless solution. The solutions were administered inside the scanner with a Magnetic Resonance Imaging (MRI)-compatible gustometer to assess neural responses during consumption. The same procedure was repeated for pre- and post-intervention sessions. Results: The liraglutide group lost more weight (BMI post-pre = - 3.19 kg/m2 ±1.28) than the placebo group (BMI post-pre = - 0.60 kg/m2 ±1.26). The sensory pleasure during food reward consumption was associated with the activation of the ventromedial prefrontal cortex (vmPFC) and the amygdala. We did not find any statistically significant difference in the liraglutide group between the pre and post sessions, neither at a subjective level nor at a neural level in terms of reactivity of the vmPFC to the milkshake.Conclusions: These results suggest that liraglutide leads to weight loss without self-report or neural evidence supporting a concomitant reduction of food-related sensory pleasure in patients with from obesity.
Relationship between pain management and women´s satisfaction during labour. A Randomized Controlled Trial.
Authors: Aníbal Báez-Suárez , Estela Martín-Castillo , Josué García-Andújar , Ángel García-Hernández José , P. Quintana-Montesdeoca María , Francisco Loro-Ferrer Juan 
Published: July 2022

Abstract
Background: The factors related to the satisfaction of women during labour vary widely. Pain relief is one of the fundamental weaknesses, so it could influence the rating of the rest of the satisfaction items. The use of Transcutaneous Electrical Nerve Stimulation (TENS), like a non-pharmacologic pain relief approach, is a safe and effective technique used during childbirth. Measure for Testing Satisfaction (COMFORTS) scale is a specific questionnaire that includes the most important factors associated with the relation between mother satisfaction and the childbirth experience. The aim is to analyse factors influencing satisfaction in pregnant women during labour and its relationship with pain management.Methods: A randomized and double-blind controlled trial was conducted. All participants completed the satisfaction scale immediately after childbirth. A total of 63 participants were randomly assigned to one Transcutaneous electric nerve stimulation (TENS) device to relieve the pain, with different dose in each patients group. This was measured with two scales; the satisfaction level was measured with the COMFORTS scale and pain was measured with the Visual Analogue Scale (VAS). Results: the total satisfaction scale mean score was 171.03 (SD 19.69) with an individual item mean of 4.28. Women who expressed a low level of satisfaction had experienced severe pain. A lower degree of satisfaction was observed in women with severe pain (3.03 ± 1.1) than in women with moderate pain (4.53 ± 0.7). Women who have had more than one delivery presented the highest level of satisfaction, followed by nulliparous and those who have had a previous pregnancy. Conclusions: Overall, high level of satisfaction during labour was obtained; we recommend the use of Transcutaneous electrical nerve stimulation for pain relief to improve general satisfaction.Trial registration: ClinicalTrials.gov ID: NCT03137251.
Evidence of pair-correlation of which-way effects in the asymmetrical double-slit interference
Authors: Van Thuan Vo , Duc Vinh Vu , Thanh Hung Nguyen , Quang Thieu Dang 
Published: July 2022

Abstract
The problem of physical reality in quantum mechanics has been raised since the famous Einstein-Bohr debate at the 5th Solvey conference in 1927. Ignoring the reality of a quantum matter existing independent of human observation, Bohr proposed an interpretation through the principle of complementarity, which negates simultaneous measurements of both characteristics of wave-particle duality. Until now, the issue remains unresolved and has received increasing attention over the past decade. Here we show for the first time a novel experimental correlation between two substitutionary which-way effects in asymmetrical double-slit experiments performed under the far-field Fraunhofer condition. The identifiable paired fringes can be seen in the self-interference spectra of single photons, travelling through different paths as point-like particles. The correlation greatly improves the confidence level and turns the present experiment into unambiguous evidence for the simultaneous measurement of wave-particle duality to the ontological physical reality of photons against the orthodox interpretation of quantum mechanics.
Optimization of Wire Electric Discharge Machining (WEDM) process parameters for AISI 1045 Medium Carbon Steel using Taguchi Design of Experiment
Authors: Ahmed Usman , Zaman Uzair Khaleeq Uz , Asghar Eram , Baqai Aamer Ahmed , Butt Sajid Ullah 
Published: July 2022

Abstract
The demand for alloy materials with high hardness, toughness, and impact strength has increased with the growth of the manufacturing industry. These materials are extremely difficult to manufacture using standard techniques, hence, non-conventional machining is used to solve this problem. Wire cut electric discharge machine is one of them. Thus, to attain the required outcome or productivity, it is necessary to control the input parameters that affect the response factors. This research aims to optimize the wire cut electric discharge machining process parameters using the Taguchi design of experiment (DOE) for AISI 1045 medium carbon steel. In this work, experiments are performed in an automotive sector to analyze the influence of WEDM process parameters such as current, voltage, and pulse on time on material removal rate (MRR) for AISI 1045 medium carbon steel. The signal-to-noise (S/N) ratio and analysis of variance are used to analyze the impact of error in this experiment, establishing the best set of process parameters for optimizing the material removal rate. According to the present investigation, the current has a significant effect on the material removal rate. The observed optimal process parameter settings for higher material removal rate based on the Taguchi DOE were found to be, I=16amp,V=60volt, pulse on time =100µs .The conclusion of the paper includes the disclosure of findings, analysis, and judgments.
Inorganic sorbents on the base of magnesium silicates obtained by two synthetic routes
Authors: Kravchenko Mycola V. , Khodakovska Tatiana A. , Kovtun Maria F. , Romanova Irina V. 
Published: July 2022

Abstract
In the present study three novel inorganic ion exchange materials on the base of magnesium silicates were synthesized by precipitation and hydrothermal sol gel methods with two reagents ratio. Physico-chemical properties of samples were characterized by thermogravemetric and differential thermal analyses, low temperature adsorption/desorption method and transmission electron microscopic studies. It was found that all sorbents were obtained in a form of amorphous layer-structure magnesium silicates with micro- and mesoporous structure. The ion exchange properties of these materials for Cs+, Sr2+ Cu2+, Co2+and Cd2+ removing from water solution investigated. Data obtained showed that magnesium silicates had the higher capacity toward the heavy metal cations compared to the radionuclides regardless the method used for synthesis. The sample synthesized with excess of metasilicate exhibited the higher efficiency of heavy metal cations sorption than the sample obtained using equimolar ratio of components. Amongst Langmuir and Freundlich models, Langmuir model fitted well for experimental data received on these adsorbents.
Neurological Type Wilson’s Disease: Epidemiology, Clinical Manifestations, Diagnosis, and Management
Authors: Kipker Nathaniel , Alessi Kaitlyn , Bojkovic Marko , Padda Inderbir , Parmar Mayur 
Published: July 2022

Abstract
Wilson's disease (WD) is a complex metabolic disorder caused by disruptions to copper regulation within the body, leading to an unregulated accumulation of copper within various tissues. A less understood organ affected by the collection of copper is the brain, which further leads to the generation of oxygen free radicals and resultant demyelination. Healthcare providers need to keep the neurological form of WD in their list of differentials when patients present with diverse neurological manifestations. Being able to distinguish the characteristic disease presentation with a thorough history and physical and neurological examination will be the initial step to diagnosis. A high clinical disease suspicion of WD should warrant further investigation by laboratory workup and imaging modalities to support the clinical findings and confirm the diagnosis of WD. Once a WD diagnosis is established, the healthcare provider should treat for the underlying biological process of WD and symptomatically. This review article discusses the epidemiology and pathogenesis of the neurological form of Wilson's disease, its clinical and behavioral implications, diagnostic features, and treatment modalities, further aiding healthcare professionals in an early diagnosis and management strategies.
Comparison of comorbidity incidences between hypokalemia and normokalemia primary aldosteronism patients
Authors: Zhang Qinghui , Chen Jie , wu Xian-xian , Kong De-Hui , Liu Xue , Yang Zhi-wei , Liu Min 
Published: July 2022

Abstract
Little information is available on apparent differences in comorbidities between hypokalemia and normokalemia in primary aldosteronism (PA) patients. Our study aimed to evaluate the differences regarding comorbidities of PA patients with different serum potassium levels. A total of 629 PA patients were enrolled and divided into hypokalemic and normokalemic types of PA. The general clinical characteristics and related biochemical parameters were collected in all subjects. The incidences of different comorbidities in hypokalemia and normokalemia PA patients were analyzed. Of the 629 patients (49.86 ± 11.66 years, range 18–79), 26.9% had hypokalemic PA. The systolic blood pressures (158.43 ± 2.35 vs. 150.84 ± 21.57 mmHg; P < 0.001), diastolic blood pressures (96.57 ± 15.51 vs. 91.98 ± 15.77 mmHg; P < 0.05) and plasma aldosterone concentration (P < 0.001) were significantly higher in hypokalemic PA patients than those in normokalemic PA patients. The hypokalemic PA patients had higher urinary microalbumin than normokalemic PA patients (P < 0.05). There was a negative correlation between serum potassium level and level of orthostatic aldosterone concentration and systolic blood pressure, The incidences of obstructive sleep apnea were higher in hypokalemic than those in normokalemic PA patients (P < 0.05). Our data suggest that high prevalence of comorbidities presented in patients with PA. The hypokalemic PA patients had higher incidence of obstructive sleep apnea than the normokalemic PA patients. Therefore, PA's early diagnosis and treatment, especially for the patients with hypokalemic PA, are essential.