bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for a systematic review on systemic and skin toxicity of important hazardous hair and nail cosmetic ingredients in hairdressers
Authors: Uter Wolfgang , Johansen Jeanne D. , Havmose Martin S. , Kezic Sanja , van der Molen Henk F. , Macan Jelena , Babić Željka , Turk Rajka , Symanzik Cara , John Swen M. 
Published: October 2022

IntroductionHairdressers constitute a major subgroup in the service sector. They are exposed to various substances hazardous for skin, airways or systemically. Accordingly, skin and other occupational diseases are common. The present systematic review will compile and appraise evidence regarding skin, systemic and airways toxicity of an indicative set of specific, important product ingredients. Additionally, evidence concerning hand eczema morbidity among hairdressers will be reviewed.Methods and analysisSystematic searches will be performed in two electronic literature databases (Medline, Web of Science–Core Collection), the Cochrane register and two collections of toxicological dossiers (Scientific Committee on Consumer Safety of the European Commission and the MAK Commission of the German Research Council). Additional literature sources will be retrieved using hand search of reference lists of included studies and snowballing methods. We will include studies with all types of quantitative study designs, including results from in vitro and in vivo experiments, chemical analysis, epidemiological findings and clinical results. We will assess the risk of bias within studies amalgamating an abbreviated version of the Mixed Methods Appraisal Tool, basic Cochrane criteria and US Environmental Protection Agency assessment factors for scientific information. As we expect large heterogeneity in methods and outcomes, we will conduct a narrative synthesis of results instead of a meta-analysis, except where quantitative pooling is feasible.Ethics and disseminationEthical approval and patient consent are not required as this is a systematic review based on published studies. The results of this study will be published in international peer-reviewed journals.PROSPERO registration numberCRD42021238118
Patients’ choice of healthcare providers and predictors of modern healthcare utilisation in Bangladesh: Household Income and Expenditure Survey (HIES) 2016–2017 (BBS)
Authors: Imtiaz Asif , Khan Noor Muhammad , Hasan Emran , Johnson Shanthi , Nessa Hazera Tun 
Published: October 2022

ObjectivesThe number of modern healthcare providers in Bangladesh has increased and they are well equipped with modern medical instruments and infrastructures. Despite this development, patients seeking treatment from alternative healthcare providers are ongoing. Hence, this study aims to determine the underlying predictors of patients’ choosing modern healthcare providers and health facilities for getting treatments.SettingData from the nationally representative Household Income and Expenditure Survey 2016–2017 conducted by the Bangladesh Bureau of Statistics were used.Participants34 512 respondents sought treatment for their illnesses from different types of available healthcare providers.Primary and secondary outcome measurePatients’ choice of healthcare providers (primary) and predictors of patients’ choice of modern healthcare providers (secondary).ResultsThe study found that 40% of the patients visit modern healthcare providers primarily on having symptoms of illness, and the remainder goes to alternative healthcare providers. Patients living in urban areas (adjusted OR (AOR)=1.11, 95% CI 1.05 to 1.17, p<0.01), and if the travel time was between 1 and 2 hours (AOR=1.11, 95% CI 1.00 to 1.22, p<0.05) compared with travel time less than 1 hour, were positively associated to utilisation of modern healthcare facilities for their first consultation. The statistical models show that the predisposing and need factors do not significantly impact patients’ choice of modern healthcare providers.ConclusionsThe distribution of modern healthcare providers should be even across the country to eliminate the rural–urban divide in modern healthcare utilisation. Enhancing the digital provision of modern healthcare services could reduce travel time, omit transportation costs and save waiting time for treatment by the modern healthcare providers. Policymakers can think of introducing a national health insurance programme in Bangladesh as a potential policy instrument.
Audit of data redaction practices in NICE technology appraisals from 1999 to 2019
Authors: Osipenko Leeza 
Published: October 2022

ObjectivesTo assess the extent and type of data redaction in all active technology appraisals (TA) and highly specialised technology (HST) evaluations issued by the National Institute for Health and Care Excellence (NICE) from its conception of the institute to September 2019. To propose policy recommendations for transparency.MethodsStructured audit to establish extent of data redaction—proportion of appraisals and specific data categories and assess redaction by: indication, appraisal process, manufacturer, type of data—price, adverse events (AEs), clinical (excluding AEs), incremental quality-adjusted life-years. Longitudinal analysis over 20 years.ResultsAll TAs with available documentation and active recommendations (n=408) and HSTs (n=10) published from March 2000 to 11 September 2019 have been assessed for data redaction. Overall, 333 TAs (81.6%) have data redaction, 86 (25.8%) of them are heavily redacted. Clinical data (excluding AEs) are redacted in 268 (65.7%) appraisals, AE data in 128 (31.4%), price in 238 (58.3%). In total, 87% of oncology appraisals have redacted data vs 78% of non-oncology appraisals. 91% of single TAs have redacted data vs 59% of multiple TAs. 25% of final guidance documents (e.g. Final Appraisal Determination - FAD) do not report one or more instance of clinical data. Data redaction increased substantially over time, and is currently at its highest level with 100% of TAs having at least some data redaction in 2019/2020, 96% of appraisals in 2018/2019% and 94% of appraisals in 2017/2018. All 10 HST evaluations have redacted data, with 4 of them being heavily redacted.ConclusionsDocuments supporting NICE TA and HST recommendations are significantly redacted, thereby concealing clinical and economic data of importance to patients, clinicians and researchers. Documents remain redacted on the NICE website for years. Policy change is required to ensure transparency of data underpinning NICE’s decisions.
Mode of birth in women with low-lying placenta: protocol for a prospective multicentre 1:3 matched case–control study in Italy (the MODEL-PLACENTA study)
Authors: Ornaghi Sara , Colciago Elisabetta , Vaglio Tessitore Isadora , Abbamondi Alessandra , Antolini Laura , Locatelli Anna , Inversetti Annalisa , Pintucci Armando , Cetin I , Bracco Benedetta , Fabbri Elisa , Sala Valentina , Meroni Mario , Volpe Grazia , Benedetti Sara , Bulfoni Camilla , Marconi Annamaria , Lagrasta Federica , Paolini Cinzia Lucia , Mazza Elisabetta , Candiani Massimo , Valsecchi Luca , Smid Maddalena , Pasi Federica , Pozzoni Mirko , Castoldi Maria , Vignali Michele , Dal Molin Giulia , Guarano Alice , Pellegrino Antonio , Callegari Clelia , Betti Marta , Lazzarin Sara , Prefumo Federico , Zanardini Cristina , Parolin Valentina , Catalano Anna , Barbolini Edoardo , Antonazzo Patrizio , Pignatti Lucrezia , Tintoni Mauro , Spelzini Federico , Martinelli Anna , Facchinetti Fabio , Chiossi G , Vergani Patrizia 
Published: October 2022

IntroductionThe term placenta praevia defines a placenta that lies over the internal os, whereas the term low-lying placenta identifies a placenta that is partially implanted in the lower uterine segment with the inferior placental edge located at 1–20 mm from the internal cervical os (internal-os-distance). The most appropriate mode of birth in women with low-lying placenta is still controversial, with the majority of them undergoing caesarean section. The current project aims to evaluate the rate of vaginal birth and caesarean section in labour due to bleeding by offering a trial of labour to all women with an internal-os-distance >5 mm as assessed by transvaginal sonography in the late third trimester.Methods and analysisThe MODEL-PLACENTA is a prospective, multicentre, 1:3 matched case–control study involving 17 Maternity Units across Lombardy and Emilia-Romagna regions, Italy. The study includes women with a placenta located in the lower uterine segment at the second trimester scan. Women with a normally located placenta will be enrolled as controls. A sample size of 30 women with an internal-os-distance >5 mm at the late third trimester scan is needed at each participating Unit. Since the incidence of low-lying placenta decreases from 2% in the second trimester to 0.4% at the end of pregnancy, 150 women should be recruited at each centre at the second trimester scan. A vaginal birth rate ≥60% in women with an internal-os-distance >5 mm will be considered appropriate to start routinely admitting to labour these women.Ethics and disseminationEthical approval for the study was given by the Brianza Ethics Committee (No 3157, 2019). Written informed consent will be obtained from study participants. Results will be disseminated by publication in peer-reviewed journals and presentation in international conferences.Trial registration numberNCT04827433(pre-results stage)
Anaesthesia protocol evaluation of the videolaryngoscopy with the McGrath MAC and direct laryngoscopy for tracheal intubation in 1000 patients undergoing rapid sequence induction: the randomised multicentre LARA trial study protocol
Authors: Kriege Marc , Lang Philipp , Lang Christoph , Pirlich Nina , Griemert Eva-Verena , Heid Florian , Wittenmeier Eva , Schmidtmann Irene , Schmidbauer W , Jänig Christoph , Jungbecker Johannes , Kunitz Oliver , Strate Maximilian , Schmutz Axel 
Published: October 2022

IntroductionRapid sequence induction of anaesthesia is indicated in patients with an increased risk of pulmonary aspiration. The main objective of the technique is to reduce the critical time period between loss of airway protective reflexes and rapid inflation of the cuff of the endotracheal tube to minimise the chance of aspiration of gastric contents. The COVID-19 pandemic has reinforced the importance of first-pass intubation success to ensure patient and healthcare worker safety. The aim of this study is to compare the first-pass intubation success rate (FPS) using the videolaryngoscopy compared with conventional direct laryngoscopy in surgical patients with a high risk of pulmonary aspiration.Methods and analysisThe LARA trial is a multicentre, patient-blinded, randomised controlled trial. Consecutive patients requiring tracheal intubation are randomly allocated to either the McGrath MAC videolaryngoscope or direct laryngoscopy using the Macintosh laryngoscope. The expected rate of FPS is 92% in the McGrath group and 82% in the Macintosh group. Each group must include a total of 500 patients to achieve 90% power for detecting a difference at the 5% significance level. Successful intubation with the FPS is the primary endpoint. The secondary endpoints are the time to intubation, the number of intubation attempts, the necessity of airway management alternatives, the visualisation of the glottis using the Cormack and Lehane Score and the Percentage Of Glottic Opening Score and definite adverse events.Ethics and disseminationThe project is approved by the local ethics committee of the Medical Association of the Rhineland Palatine state (registration number: 2020–15502) and medical ethics committee of the University of Freiburg (registration number: 21–1303). The results of this study will be made available in form of manuscripts for publication and presentations at national and international meetings.Trial registrationNCT04794764.
Sexual abuse of people with intellectual disabilities in residential settings: a 3-year analysis of incidents reported to the Dutch Health and Youth Care Inspectorate
Authors: Amelink Quirine , Roozen Selini , Leistikow Ian , Weenink Jan-Willem 
Published: October 2022

ObjectivesTo explore characteristics of sexual abuse within residential settings for people with an intellectual disability and to map out measures undertaken and improvement plans made by healthcare organisations after sexual abuse.DesignDescriptive analysis of reports about sexual violence against persons with an intellectual disability submitted to the Dutch Health and Youth Care Inspectorate by healthcare organisations.SettingResidential settings for people with an intellectual disability in The Netherlands.Selection186 incident reports submitted to the Inspectorate between January 2017 and December 2019 were included.Results125 incident reports concerned sexual abuse by fellow clients and 61 reports concerned sexual abuse by professionals. Client perpetrators were predominantly male whereas almost 30% of the abusing professionals were female. The majority of the perpetrating professionals were unlicensed professionals. Clients who committed sexual abuse were mostly relocated to another residential setting. Most healthcare organisations invested in education and training for employees instead of improving the sexual education programme for clients after an incident of sexual abuse. If there was a strong suspicion of sexual abuse by a professional, resignation followed in most cases. In just two cases, the perpetrating professional was reported to a warning registry.ConclusionsA small amount of the perpetrating professionals held a licensed profession, which makes it challenging to address this form of sexual abuse through healthcare regulation. It raises the question why warning registries are not engaged more often after alleged sexual abuse. Constantly relocating abusing clients might endanger the (sexual) safety of clients in these new environments. Previous literature suggests that adequate sexual education regarding social skills and sexual behaviour is very effective for the majority of clients who commit sexual abuse. Healthcare organisations could take up a more prominent role in this to ensure safety for their own clients and for clients residing elsewhere.
Understanding variations in reported epidemiology of major lower extremity amputation in the UK: a systematic review
Authors: Meffen Anna , Houghton John S M , Nickinson Andrew T O , Pepper Coral J , Sayers Robert D , Gray Laura J 
Published: October 2022

ObjectiveEstimate the prevalence/incidence/number of major lower extremity amputations (MLEAs) in the UK; identify sources of routinely collected electronic health data used; assess time trends and regional variation; and identify reasons for variation in reported incidence/prevalence of MLEA.DesignSystematic review and narrative synthesis.Data sourcesMedline, Embase, EMcare, CINAHL, The Cochrane Library, AMED, Scopus and grey literature sources searched from 1 January 2009 to 1 August 2021.Eligibility criteria for selecting studiesReports that provided population-based statistics, used routinely collected electronic health data, gave a measure of MLEA in adults in the general population or those with diabetes in the UK or constituent countries were included.Data extraction and synthesisData extraction and quality assessment using the Joanna Briggs Institute Critical Appraisal Instruments were performed by two reviewers independently. Due to considerable differences in study populations and methodology, data pooling was not possible; data were tabulated and narratively synthesised, and study differences were discussed.ResultsTwenty-seven reports were included. Incidence proportion for the general population ranged from 8.2 to 51.1 per 100 000 and from 70 to 291 per 100 000 for the population with diabetes. Evidence for trends over time was mixed, but there was no evidence of increasing incidence. Reports consistently found regional variation in England with incidence higher in the north. No studies reported prevalence. Differences in database use, MLEA definition, calculation methods and multiple procedure inclusion which, together with identified inaccuracies, may account for the variation in incidence.ConclusionsUK incidence and trends in MLEA remain unclear; estimates vary widely due to differences in methodology and inaccuracies. Reasons for regional variation also remain unexplained and prevalence uninvestigated. International consensus on the definition of MLEA and medical code list is needed. Future research should recommend standards for the reporting of such outcomes and investigate further the potential to use primary care data in MLEA epidemiology.Systematic review registrationPROSPERO CRD42020165592.
Temporal Dynamic Concept Modeling Network for Explainable Video Event Recognition
Authors: Zhang Weigang , Qi Zhaobo , Wang Shuhui , Su Chi , Su Li , Huang Qingming 
Published: October 2022

Recently, with the vigorous development of deep learning and multimedia technology, intelligent urban computing has received more and more extensive attention from academia and industry. Unfortunately, most of the related technologies are black-box paradigms that lack interpretability. Among them, video event recognition is a basic technology. Event contains multiple concepts and their rich interactions, which can assist us to construct explainable event recognition methods. However, the crucial concepts needed to recognize events have various temporal existing patterns, and the relationship between events and the temporal characteristics of concepts has not been fully exploited. This brings great challenges for concept-based event categorization. To address the above issues, we introduce the temporal concept receptive field, which is the length of the temporal window size required to capture key concepts for concept-based event recognition methods. Accordingly, we introduce the temporal dynamic convolution (TDC) to model the temporal concept receptive field dynamically according to different events. Its core idea is to combine the results of multiple convolution layers with the learned coefficients from two complementary perspectives. These convolution layers contain a variety of kernel sizes, which can provide temporal concept receptive fields of different lengths. Similarly, we also propose the cross-domain temporal dynamic convolution (CrTDC) with the help of the rich relationship between different concepts. Different coefficients can help us to capture suitable temporal concept receptive field sizes and highlight crucial concepts to obtain accurate and complete concept representations for event analysis. Based on the TDC and CrTDC, we introduce the temporal dynamic concept modeling network (TDCMN) for explainable video event recognition. We evaluate TDCMN on large-scale and challenging datasets FCVID, ActivityNet, and CCV. Experimental results show that TDCMN significantly improves the event recognition performance of concept-based methods, and the explainability of our method inspires us to construct more explainable models from the perspective of the temporal concept receptive field.
Self-aware Optimization of Adaptation Planning Strategies
Authors: Lesch Veronika , Hadry Marius , Krupitzer Christian , Kounev Samuel 
Published: October 2022

In today’s world, circumstances, processes, and requirements for software systems are becoming increasingly complex. To operate properly in such dynamic environments, software systems must adapt to these changes, which has led to the research area of Self-Adaptive Systems (SAS). Platooning is one example of adaptive systems in Intelligent Transportation Systems, which is the ability of vehicles to travel with close inter-vehicle distances. This technology leads to an increase in road throughput and safety, which directly addresses the increased infrastructure needs due to increased traffic on the roads. However, the No-Free-Lunch theorem states that the performance of one adaptation planning strategy is not necessarily transferable to other problems. Moreover, especially in the field of SAS, the selection of the most appropriate strategy depends on the current situation of the system. In this article, we address the problem of self-aware optimization of adaptation planning strategies by designing a framework that includes situation detection, strategy selection, and parameter optimization of the selected strategies. We apply our approach on the case study platooning coordination and evaluate the performance of the proposed framework.
Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma
Authors: Haertle Larissa , Barrio Santiago , Munawar Umair , Han Seungbin , Zhou Xiang , Simicek Michal , Vogt Cornelia , Truger Marietta , Fernandez Rafael Alonso , Steinhardt Maximilian , Weingart Julia , Snaurova Renata , Nerreter Silvia , Teufel Eva , Garitano-Trojaola Andoni , Da Viá Matteo , Ruiz-Heredia Yanira , Rosenwald Andreas , Bolli Niccolò , Hajek Roman , Raab Peter , Raab Marc S. , Weinhold Niels , Haferlach Claudia , Haaf Thomas , Martinez-Lopez Joaquin , Einsele Hermann , Rasche Leo , Kortüm K. Martin 
Published: October 2022

Abstract

Purpose:
Proteasome inhibitors (PI) are the backbone of various treatment regimens in multiple myeloma. We recently described the first in-patient point mutations affecting the 20S subunit PSMB5 underlying PI resistance. Notably, in vivo, the incidence of mutations in PSMB5 and other proteasome encoding genes is too low to explain the development of resistance in most of the affected patients. Thus, additional genetic and epigenetic alterations need to be explored.

Experimental Design:
We performed DNA methylation profiling by Deep Bisulfite Sequencing in PSMB5, PSMC2, PSMC5, PSMC6, PSMD1, and PSMD5, a subset of proteasome subunits that have hitherto been associated with PI resistance, recruited from our own previous research, the literature, or a meta-analysis on the frequency of somatic mutations. Methylation was followed up on gene expression level and by dual-luciferase reporter assay. The KMS11 cell line served as a model to functionally test the impact of demethylating agents.

Results:
We identified PSMD5 promoter hypermethylation and subsequent epigenetic gene silencing in 24% of PI refractory patients. Hypermethylation correlated with decreased expression and the regulatory impact of this region was functionally confirmed. In contrast, patients with newly diagnosed multiple myeloma, along with peripheral blood mononuclear cells and CD138+ plasma cells from healthy donors, generally show unmethylated profiles.

Conclusions:
Under the selective pressure of PI treatment, multiple myeloma cells acquire methylation of the PSMD5 promoter silencing the PSMD5 gene expression. PSMD5 acts as a key orchestrator of proteasome assembly and its downregulation was described to increase the cell's proteolytic capacity. PSMD5 hypermethylation, therefore, represents a novel mechanism of PI tolerance in multiple myeloma.