bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized thermo-mechanical framework for heterogeneous materials through asymptotic homogenization
Authors: Vazic Bozo , Abali Bilen Emek , Newell Pania 
Published: November 2022

AbstractA fundamental understanding of the interaction between microstructure and underlying physical mechanisms is essential, especially for developing more accurate multi-physics models for heterogeneous materials. Effects of microstructure on the material response at the macroscale are modeled by using the generalized thermomechanics. In this study, strain gradient theory is employed as a higher-order theory on the macroscale with thermodynamics modeled as a first-order theory on the microscale. Hence, energy depends only on the temperature such that we circumvent an extension of Fourier’s law and analyze the “simplest” thermo-mechanical model in strain gradient elasticity. Developing multiphysics models for heterogeneous materials is indeed a challenge and even this “simplest” model in generalized thermomechanics creates dozens of parameters to be determined. We develop a thermo-mechanical framework, in which microstructure is modeled as a periodic structure and through asymptotic homogenization approach, higher-order parameters at macroscopic scale are calculated. To illustrate the importance of higher-order parameters in overall thermo-mechanical response of a heterogeneous materials, finite element method (FEM) is employed with the aid of open-source codes (FEniCS). Verification example of a bulk system and several case studies of porous structures demonstrate how such numerical framework can be beneficial in the design of materials with tailored microstructures.
Influence of oxygen content in the shielding gas chamber on mechanical properties and macroscopic structure of Ti-6Al-4V during wire arc additive manufacturing
Authors: Halisch Christoph , Milcke Björn , Radel Tim , Rentsch Rüdiger , Seefeld Thomas 
Published: November 2022

AbstractWire arc additive manufacturing (WAAM) of titanium parts shows promising potential for aerospace application due to its high deposition rates allowing a fast and economical production of large components. The cost savings are high, especially for expensive alloys like Ti-6Al-4V. However, due to high oxygen affinity of Ti-6Al-4V at elevated temperatures an excellent shielding gas coverage seems necessary to prevent embrittlement of the material during the welding process. Regarding the future development of local shielding gas coverage set-ups for gas metal arc welding (GMAW) based WAAM, this study investigates the influence of the oxygen content in the shielding gas chamber on mechanical properties of Ti-6Al-4V during the welding process. Samples are welded at different oxygen contents in the shielding gas chamber and stress-relief heat treated afterwards. Inert gas milling and hot gas extraction are used to determine the material oxygen content at different deposition heights. Metallographic methods are used to show macroscopic grain structure, evaluate possible α-case thickness and its dissolution by the subsequent layer. Hardness testing is used to investigate possible material inhomogeneities in the deposit and tensile properties of the material welded at different chamber oxygen contents are displayed. It is concluded, that even at high chamber oxygen levels of 6000 ppm the welding process is stable, the forming α-case at top of the layer dissolves in the melt pool of the subsequent layer and that the aerospace requirements on tensile properties can be reached.
Warpage and residual stress analyses of post-mold cure process of IC packages
Authors: Lin Ming-Yu , Zeng Yong-Jie , Hwang Sheng-Jye , Wang Ming-Han , Liu Hui-Ping , Fang Chin-Lung 
Published: November 2022

AbstractTo improve the production yield rate, reliability is one of the important indicators of electronic packaging products. In past research, however, the influence of the fabrication process was rarely taken into consideration. In this thesis, mold flow analysis software Moldex3D is used to develop a series analysis procedure for IC package products. The effects of many factors, including process, structure, and materials were being taken into account. Especially for epoxy molding compound, namely EMC, is studied on its properties during the molding and post-mold cure (PMC) processes. This paper adoptedP–V-T-Cequations, which consider both volume shrinkage due to thermal mismatch and chemical shrinkage to predict the amount of warpage and residual stresses after the mold filling process. Next, dual shift factor model for viscoelastic analysis was used to model the PMC process and predict the amount of warpage and residual stresses after PMC. And the influence of different PMC process conditions and loading conditions on the warpage results is discussed. The residual stresses after PMC simulation are set as the initial conditions for reliability analysis and then the stress distribution after two thermal cycles is analyzed. It is observed that the deformed shape of the simulation and experiment results after PMC were consistent. Both are concave downwards. In comparison with experiment results, the error of warpage simulation results was between 10% and 50%. The biggest error was found in the short direction. During two thermal cycles, it is can be found that the maximum stress of the lead frame is 505.7 MPa and the location of the possible failure is at the top left of the die. In addition, when considering or not considering the process-induced residual stress in the thermal cycle analysis, the stress states are very different.
FGF-23 protects cell function and viability in murine pancreatic islets challenged by glucolipotoxicity
Authors: Pajaziti Betina , Yosy Kenneth , Steinberg Olga V. , Düfer Martina 
Published: November 2022

AbstractThe fibroblast growth factor FGF-23 is a member of the FGF-15/19 subfamily with hormonal functions. Besides its well-known role for bone mineralization, FGF-23 is discussed as a marker for cardiovascular disease. We investigated whether FGF-23 has any effects on the endocrine pancreas of mice by determining insulin secretion, electrical activity, intracellular Ca2+, and apoptosis. Acute application of FGF-23 (10 to 500 ng/ml, i.e., 0.4 to 20 nM) does not affect insulin release of murine islets, while prolonged exposure leads to a 21% decrease in glucose-stimulated secretion. The present study shows for the first time that FGF-23 (100 or 500 ng/ml) partially protects against impairment of insulin secretion and apoptotic cell death induced by glucolipotoxicity. The reduction of apoptosis by FGF-23 is approximately twofold higher compared to FGF-21 or FGF-15/19. In contrast to FGF-23 and FGF-21, FGF-15/19 is clearly pro-apoptotic under control conditions. The beneficial effect of FGF-23 against glucolipotoxicity involves interactions with the stimulus-secretion cascade of beta-cells. Electrical activity and the rise in the cytosolic Ca2+ concentration of islets in response to acute glucose stimulation increase after glucolipotoxic culture (48 h). Co-culture with FGF-23 further elevates the glucose-mediated effects on both parameters. Protection against apoptosis and glucolipotoxic impairment of insulin release by FGF-23 is prevented, when calcineurin is inhibited by tacrolimus or when c-Jun N-terminal kinase (JNK) is blocked by SP600125. In conclusion, our data suggest that FGF-23 can activate compensatory mechanisms to maintain beta-cell function and integrity of islets of Langerhans during excessive glucose and lipid supply.
IRON NIKE Forschungstätigkeiten 2022 am Zentrum am Berg
Authors: Gegenhuber Nina , Wenighofer Robert , Nieß Birgit 
Published: November 2022

ZusammenfassungUm die Sicherheit von Zivilisten und Einsatzkräften in Ernstfällen, wie bei Terrorereignissen oder Bränden, zu verbessern, wurde in den letzten Jahren intensive Forschung betrieben. Daher fand vom 11. Juli 2022 bis 14. Juli 2022 am Zentrum am Berg auf dem steirischen Erzberg (Österreich) die IRON NIKE Forschungswoche statt, in der die Forschungsergebnisse der vergangenen Jahre zusammengebracht, analysiert, weiterentwickelt wurden und diese in der Zukunft in der Praxis anwendbar werden. Die folgenden Projekte fanden dabei ihren Auftritt: NIKE DHQ Radiv, NIKE SubmoveCon, NIKE Bluetrack sowie NIKE RasPos. Gerade die Möglichkeiten und Forschungsumgebung, die für eine solche Zusammenarbeit nötig sind, werden am Zentrum am Berg in einzigartiger Weise geboten. Der hervorragende Output wird sich dabei in den kommenden Monaten in einigen Publikationen wiederfinden. Eine solche Vielzahl an unterschiedlichen Spitzenforscher zusammenzubringen sollte auch für die Zukunft ein Ziel sein.
Microscale THMC Modeling of Pressure Solution in Salt Rock: Impacts of Geometry and Temperature
Authors: Hu Mengsu , Steefel Carl I. , Rutqvist Jonny , Gilbert Benjamin 
Published: November 2022

AbstractPressure solution, a mechanism that involves tight coupling between the geometry and thermal-hydro-mechanical-chemical (THMC) processes, plays an important role in diagenesis. In this study, we make the first attempt to conduct microscale THMC modeling to understand and quantify the impacts of geometry and temperature on pressure solution, taking natural salt rock as an example. This modeling capability is achieved by expanding a novel MC code that we developed previously (Hu et al. J Geophys Res: Solid Earth 126:e2021JB023112, 2021) to include temperature effects. We first conduct a simulation of an example that involves a single brine inclusion within a single halite grain and find that the temperature impact is limited for that case. We then extract geometry from an image of a natural salt rock and conduct simulations with different cases: (A) only temperature and no stress, (B) only stress and no temperature, and (C) with both stress and temperature. These different cases result in quite different phenomena. In case A, dissolution and precipitation occur across the entire system due to isolated pore space reaching a localized mass balance between dissolution, precipitation, and diffusion. In case B, intense geometric features (e.g., major asperities, inclusions) in one area undergo stress concentration, thus dominating pressure solution in that area. In case C, pressure solution is spread out at contacting highly stressed geometric features close to the hotter side. We conclude that geometric features dominate stress distribution, thus dominating pressure solution in a natural salt rock that may be affected by the temperature if a sufficient temperature gradient is applied.
Zwischen Notfall und Fehleinsatz – eine retrospektive Analyse der Einsätze eines Notarzteinsatzfahrzeugs in Frankfurt am Main von 2014 bis 2019
Authors: Schubert Leonie , Naujoks Frank , Störmann Philipp , Rüsseler Miriam , Herrmann Eva , Chobotsky Holger , Marzi Ingo , Wagner Nils 
Published: November 2022

Zusammenfassung
Hintergrund
Ein steigendes Einsatzaufkommen lässt sich sowohl im Rettungsdienst als auch im notärztlichen System in Deutschland verzeichnen. Oft werden dabei Fehleinsätze durch leicht erkrankte/verletzte Patienten als wachsende Problematik vermutet. Die vorliegende Untersuchung überprüft die Hypothese von steigenden Einsatzzahlen mit gleichzeitiger Zunahme von gegebenenfalls nichtindizierten Einsätzen.

Material und Methoden
Es erfolgte eine retrospektive Analyse der notärztlichen Einsätze des an der Universitätsklinik Frankfurt am Main stationierten Notarzteinsatzfahrzeugs von 2014 bis 2019. Die Analyse berücksichtigt zudem Faktoren wie die notärztliche Tätigkeit, Behandlungspriorität, Alarmierungsart und das Patientenalter.

Ergebnisse
Im beobachteten Zeitraum lässt sich ein Anstieg der notärztlichen Einsatzzahlen um mehr als 20 % erkennen. Der größte Anstieg zeigt sich bei Einsätzen, bei denen keine notärztliche Tätigkeit (+80 %) notwendig war. Einsätze der niedrigsten Behandlungspriorität (+61 %) sowie der höchsten Behandlungspriorität (+61 %) nahmen ebenfalls signifikant zu.

Diskussion
Die vorliegenden Zahlen stützen die Hypothese, dass bei signifikant gesteigertem Einsatzaufkommen mehr Einsätze durch den Notarzt bewältigt werden müssen, bei denen er rückblickend nicht notwendig gewesen wäre. Trotzdem gibt es auch mehr Patienten, die einen sofortigen Arztkontakt benötigen. Die hieraus resultierende erhöhte Einsatzfrequenz kann zu einer erhöhten Belastung sowie erschwerten zeitgerechten Disposition der notärztlichen Ressource führen.

Graphic abstract
The economic impact of comorbidity in multiple sclerosis
Authors: Ponzio Michela , Monti Maria Cristina , Mallucci Giulia , Borrelli Paola , Fusco Sara , Tacchino Andrea , Brichetto Giampaolo , Tronconi Livio , Montomoli Cristina , Bergamaschi Roberto 
Published: November 2022

Abstract

Background
Comorbid conditions are common in people with multiple sclerosis (pwMS). They can delay diagnosis and negatively impact the disease course, progression of disability, therapeutic management, and adherence to treatment.

Objective
To quantify the economic impact of comorbidity in multiple sclerosis (MS), based on cost-of-illness estimates made using a bottom-up approach.

Methods
A retrospective study was carried out in two northern Italian areas. The socio-demographic and clinical information, including comorbidities data, were collected through ad hoc anonymous self-assessment questionnaire while disease costs (direct and indirect costs of disease and loss of productivity) were estimated using a bottom-up approach. Costs were compared between pwMS with and without comorbidity. Adjusted incremental costs associated with comorbidity were reported using generalized linear models with log-link and gamma distributions or two-part models.

Results
51.0% of pwMS had at least one comorbid condition. Hypertension (21.0%), depression (15.7%), and anxiety (11.7%) were the most prevalent. PwMS with comorbidity were more likely to use healthcare resources, such as hospitalizations (OR = 1.21, p < 0.001), tests (OR = 1.59, p < 0.001), and symptomatic drugs and supplements (OR = 1.89, p = 0.012), and to incur non-healthcare costs related to investment (OR = 1.32, p < 0.001), transportation (OR = 1.33, p < 0.001), services (OR = 1.33, p < 0.001), and informal care (OR = 1.43, p = 0.16). Finally, they experienced greater productivity losses (OR = 1.34, p < 0.001) than pwMS without comorbidity. The adjusted incremental annual cost per patient due to comorbidity was €3,106.9 (13% of the overall costs) with MS disability found to exponentially affect annual costs.

Conclusion
Comorbidity has health, social, and economic consequences for pwMS.
Breaking Dormancy and Enhancing Germination of Avena sterilis L. and Amaranthus retroflexus L. Weeds by Gibberellic Acid and Potassium Nitrate to Keep Soil and Crops Healthy
Authors: Rizk Tawakul Younis , Othman kholousy Ahmed Sadek , Saudy Hani Saber , Sultan Shaimaa Sayed , Abd-Alwahed Saaeid Helmy Abd-Alhalim 
Published: November 2022

AbstractSoils infested with weed seeds are considered hostile lands for crop production. In this context, great wild oat (Avena sp.) in winter seasons and redroot pigweed (Amaranthus sp.) in summer seasons represent problematic weeds in cropland fields. In a series of laboratory trials, we estimated the effects of gibberellic acid (GA3) and potassium nitrate (KNO3) on germination and seedling growth of Avena sterilis L. and Amaranthus retroflexus L. Different concentrations of GA3 and KNO3 were evaluated in randomized complete block design with four replicates. Findings revealed that GA3 at a rate of 200 mg L−1 along each of 150 and 250 mg L−1 treatment showed the maximum increases in germination percentage, radicle length, plumule length and seedling dry weight of A. sterilis L. All applied concentrations of KNO3 were similar (p ≥ 0.05) in enhancing seed germination of A. sterilis L. exceeding the control treatment. Application of GA3 at rates of 250, 500 and 750 mg L−1 surpassed the treatments of 0 and 1000 mg L−1 GA3 for activating A. retroflexus L. seeds germination. Addition of 250 and 500 mg L−1 KNO3 were the potent treatments for stimulating the radicle length of A. retroflexus L. It could be concluded that for breaking dormancy efficiently, addition of gibberellic acid or potassium nitrate with Avena sterilis L. as well as gibberellic acid with Amaranthus retroflexus L. is recommended. Such chemicals could be involved in weed management programs, since distinctive promotion of seed germination for the target weeds was achieved. This undoubtedly will keep the soil and crops healthy.
Healthcare utilisation, physical activity and mental health during COVID-19 lockdown: an interrupted time-series analysis of older adults in England
Authors: Wang Jiunn , Spencer Anne , Hulme Claire , Corbett Anne , Khan Zunera , Da Silva Miguel Vasconcelos , O’Dwyer Siobhan , Wright Natalie , Testad Ingelin , Ballard Clive , Creese Byron , Smith Richard 
Published: November 2022

AbstractCOVID-19 measures which reduce interpersonal contact may be effective in containing the transmission, but their impacts on peoples’ well-being and daily lives overtime remain unclear. Older adults are more vulnerable to both the virus and social isolation. It is therefore imperative to understand how they were affected during this period. Major concerns arising from the pandemic cover the aspects of mental health, healthcare utilisation and individual behavioural changes. Complementing the existing before-and-after analyses, we explore the impacts of easing and re-introducing COVID-19 measures by using a time-series data in England. The data was collected between May and November 2020 from the monthly surveys of the Platform for Research Online to Investigate Genetics and Cognition in Aging (PROTECT). Chi-squared analysis and interrupted time-series analysis were conducted to examine impacts of easing and re-introducing COVID-19 measures. Overall, mental health improves overtime but at a decreasing rate. The use of telephone/video consultations with a doctor or health professional presented a decreasing trend during the pandemic, whilst that of in-person consultation was increasing overtime. We observed significant variations in the time trends of mental health measures, healthcare utilisation and physical activity following the ease but not the re-introduction of COVID-19 measures. Future research is required to understand if these asymmetric impacts were driven by adaption of the people or stringency of the measures.
Exploring Self-efficacy for Condom Use in Spanish People: A Trend Analyses by Gender from 2004 to 2020
Authors: Giménez-García Cristina , Ballester-Arnal Rafael , Ruiz-Palomino Estefanía , Castro-Calvo Jesús , Gil-Llario María Dolores 
Published: November 2022

AbstractSelf-efficacy seems to be one of the most important resources for the different stages underlying condom use and STI prevention. For this reason, this study evaluates trends in self-efficacy by gender, from 2004 to 2008, 2013 and 2020 in Spain. Throughout these years, 6,698 people ranging from 17 to 40 years old, participated filling the Brief scale of condom use self-efficacy. According to our findings, despite the slight improvement in the recent years, self-efficacy still maintains a risky profile for safe sex, especially among the youngest people. Moreover, most of the traditional gender differences continue over the years with women reporting lower scores for condom purchase and men for putting them. However, these differences are not relevant in other dimensions such as using condoms despite drug consumption where women reveal worse results over the years. Therefore, our findings reaffirm the need of intensifying gendered preventive efforts aimed at Spanish people and, particularly, among the youngest.
The Effect of Alcohol and Sexual Arousal on Explicit and Implicit Condom Attitudes and Intentions to Use a Condom
Authors: Wolfs Kenny , Bos Arjan E. R. , Mevissen Fraukje E. F. , van Lankveld Jacques J. D. M. 
Published: November 2022

AbstractAlcohol and sexual arousal are contextual determinants of condomless sex. Dual-process theory postulates that two types of cognitive processing contribute to the regulation of behavior: one that is fast, intuitive and automatic, and another that is slower and deliberative. This study applied a dual-process model to investigate condomless sexual behavior, highlighting the potential importance of implicit attitudes in condomless sex. We investigated whether the impact of alcohol and sexual arousal on condom use-related attitudes and intentions was explained by diminished working memory capacity, as dual-process models suggest. We also investigated whether this effect could be explained by implicit and explicit attitudes toward condom use. Male participants (N = 30) were randomized using a 2 × 2 within-subjects design that manipulated alcohol intoxication (placebo vs. alcohol beverages) and sexual arousal (neutral vs. erotic movie clips). We measured participants’ working memory capacity, intentions to use a condom, and explicit and implicit attitudes toward condom use. Significant main effects of alcohol intoxication and sexual arousal on working memory capacity were found. No significant interaction was found for the combined effect of alcohol intoxication and sexual arousal on intentions to use a condom. There was no significant effect of implicit attitudes on intentions to use a condom, although a trend toward significance (p = 0.06) was found for the effect of implicit attitudes on intentions to use a condom when participants were in a state of alcohol intoxication. Theoretical and practical implications of this study are discussed.
Are Leaders Responsible for Meaningful Work? Perspectives from Buddhist-Enacted Leaders and Buddhist Ethics
Authors: Vu Mai Chi , Gill Roger 
Published: November 2022

AbstractThe literature on meaningful work often highlights the role of leaders in creating a sense of meaning in the work or tasks that their staff or followers carry out. However, a fundamental question arises about whether or not leaders are morally responsible for providing meaningful work when perceptions of what is meaningful may differ between leaders and followers. Drawing on Buddhist ethics and interviews with thirty-eight leaders in Vietnam who practise ‘engaged Buddhism’ in their leadership, we explore how leaders understand their roles in creating meaningfulness at work and their perceptions of how employees experience their leadership approach in this respect. On the basis of Buddhist ontology on the sense of meaningfulness, we introduce a number of leadership approaches in cultivating meaning at work that question the argument that leaders are primarily responsible for enabling or satisfying employees’ search for meaning. The study provides an alternative lens through which to examine the role of leadership from a Buddhist ethics perspective and shows how an insight from this particular tradition can enrich secular interpretations of meaningful work and leadership.