bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tratamento cirúrgico da enxaqueca: indicações, pontos de gatilhos e técnicas empregadas
Authors: Farias Ítalo Gomes , Figueiredo Bárbara Queiroz de , Carvalho Bruna Cristine Ulhoa , Alvim Cynthia Moraes , Santos Dainin Louise Ribeiro , Carvalho Eduardo Batista de , Cunha Ítalo Íris Boiba Rodrigues da , Martins Jaçone Pereira Santiago , Loureiro Liz Silva , Freitas Mariana Tainá Oliveira de 
Published: August 2022

A enxaqueca pode ser uma condição debilitante que confere um fardo substancial ao indivíduo afetado e à sociedade. Apesar dos avanços significativos no manejo médico desse distúrbio desafiador, dados clínicos revelaram uma proporção de pacientes que não respondem adequadamente à intervenção farmacológica e permanecem sintomáticos. Informações recentes sobre a patogênese da enxaqueca argumentam contra uma causa vasogênica central e fundamentam um mecanismo periférico envolvendo nervos craniofaciais comprimidos que contribuem para a geração da enxaqueca. Assim, a injeção de toxina botulínica é uma abordagem de tratamento relativamente nova com eficácia demonstrada e suporta um mecanismo periférico, e os pacientes que falham no tratamento médico ideal e experimentam melhora da dor de cabeça após a injeção em locais anatômicos específicos podem ser considerados aptos para cirurgia subsequente para descomprimir os nervos periféricos aprisionados. Portanto, a cirurgia de enxaqueca é uma perspectiva empolgante para pacientes adequadamente selecionados que sofrem de enxaqueca e continuará a ser um campo florescente repleto de oportunidades de investigação.
Molecular characterization of genus Tor from Indonesia based on 16S rRNA
Authors: Rahayu Dwi Anggorowati , Nugroho Endik Deni , Azrianingsih Rodiyati , Kurniawan Nia 
Published: August 2022

Genus Tor is Indonesia's endangered local fish however, the reports on this species from South East Asia is currently limited. This study conducted to characterize molecular genetics and phylogenetic relationship of Tor fish from East Java, West Kalimantan, Padang and North Sumatra from BPBAT Bogor collection using a partial sequence of mtDNA 16S rRNA. A total of ten samples of Genus Tor were collected, then identified based on morphological characters, and the identification was confirmed using molecular data. PCR amplicons at 542 bp in length. The construction of phylogenetic topology was made based on ML and NJ method using Kimura-2 parameter model. Based on the phylogenetic topology showed that Tor fish from Pasuruan are closely related to Tor duoronensis from Padang with a bootstrap value of 66%, while Tor duoronensis fish from North Sumatra and Tor tambra from West Kalimantan are in separated clusters. This finding also contributes to the differentiate Genus Tor from Indonesia based on polymorphic sites.
THE INFLUENCE OF PRODUCT ATTRIBUTES, VALUE PERCEPTIONS, AND CONSUMER EXPERIENCES ON CONSUMER SATISFACTION (STUDY ON UNISBANK SEMARANG STUDENTS)
Authors: Suryaningrum Andarista Yulian , Setiawan Mulyo Budi 
Published: August 2022

This study aims to examine and analyze the effect of product attributes, perceived value and consumer experience on consumer satisfaction at Unisbank Semarang students who are users of wardah products. This study is a descriptive study because it aims to determine the effect of three independent variables (product attributes, perceived value and consumer experience) on one dependent variable (consumer satisfaction). The population in this study were all Unisbank Semarang students who used Wardah products. Due to the large number of female students, the author only took 100 people in sampling. The data obtained were analyzed by factor analysis method with KMO test and factor loading, instrument reliability test and regression analysis with determinant test, F and T statistical test. The results of this study indicate that product attributes, perceived value and consumer experience have a positive and significant effect on consumer satisfaction.
Flexible Terahertz Metamaterial Biosensor for Ultra-Sensitive Detection of Hepatitis B Viral DNA Based on the Metal-Enhanced Sandwich Assay
Authors: Li Yumin , Wang Xiaojing , Liu Yu , Jin Weidong , Tian Huiyan , Xie Fengxin , Xia Ke , Zhang Xiuming , Fu Weiling , Zhang Yang 
Published: August 2022

The high sensitivity and specificity of terahertz (THz) biosensing are both promising and challenging in DNA sample detection. This study produced and refined a flexible THz MM biosensor for ultrasensitive detection of HBV in clinical serum samples based on a gold magnetic nanoparticle-mediated rolling circle amplification (GMNPs@RCA) sandwich assay under isothermal conditions. Typically, solid-phase RCA reactions mediated by circular padlock probes (PLPs) are triggered under isothermal conditions in the presence of HBV DNA, resulting in long single-stranded DNA (ssDNA) with high fidelity and specificity. Then, the resultant ssDNA was conjugated with detection probes (DPs) immobilized on gold nanoparticles (DP@AuNPs) to form GMNPs-RCA-AuNPs sandwich complexes. The HBV DNA concentrations were quantified by introducing GMNPs-RCA-AuNPs complexes into the metasurface of a flexible THz metamaterial-based biosensor chip and resulting in a red shift of the resonance peak of the THz metamaterials. This biosensor can lead to highly specific and sensitive detection with one-base mismatch discrimination and a limit of detection (LOD) down to 1.27E + 02 IU/ml of HBV DNA from clinical serum samples. The HBV DNA concentration was linearly correlated with the frequency shift of the THz metamaterials within the range of 1.27E + 02∼1.27E + 07 IU/ml, illustrating the applicability and accuracy of our assay in real clinical samples. This strategy constitutes a promising THz sensing method to identify virus DNA. In the future, it is hoped it can assist with pathogen identification and clinical diagnosis.
Synthesis, dielectric, magnetic, and photoluminescence properties of two new hybrid rare-earth double perovskites
Authors: Wang Ze-Jie , Li Long-He , Feng Yan , Wang Qin-Wen , Wu Ling-Kun , Li Jian-Rong , Ye Heng-Yun 
Published: August 2022

Two new organic–inorganic hybrid double perovskites (R3HQ)4CsSm(NO3)8 (1) (R3HQ = (R)-(-)-3-quinuclidinol) and (R3HQ)4CsEu(NO3)8 (2) were synthesized and characterized. Compounds 1 and 2 exhibit obvious phase transitions at 379 and 375 K, respectively, confirmed by differential scanning calorimetry (DSC) and variable temperature powder X-ray diffraction. The rapid switching between high- and low-dielectric states makes it a typical dielectric material with a switchable dielectric constant for thermal stimulus response. Furthermore, 1 and 2 show attractive photoluminescence and paramagnetic behavior, and the fluorescence quantum yield of 2 reached 14.6%. These results show that compounds 1 and 2 can be used as excellent candidates for multifunctional intelligent materials, which also provides a new way for development of multifunctional materials.
Band structural and absorption characteristics of antimonene/bismuthene monolayer heterojunction calculated by first-principles
Authors: Zhan Yanyan , Fang Xuan , Wang Dengkui , Fang Dan , Li Bobo , Li Jinhua , Wang Xiaohua 
Published: August 2022

The band gap of lateral heterojunctions (LHSs) can be continuously tuned by changing the widths of their components. In this work, Sb/Bi LHSs based on monolayer Sb and Bi atoms with armchair and zigzag interfaces are constructed, respectively. It exhibits an atom’s number in planner-dependent tunable band gap and near-infrared range absorption characteristics. They are systematically studied by first-principles calculations. The widths are represented by the number (n) of Sb or Bi atom chains. When n increases from 2 to 8, the bandgaps of armchair Sbn/Bin LHSs decrease from 0.89 to 0.67 eV, and the band gaps of zigzag Sbn/Bin LHSs decrease from 0.92 to 0.76 eV. The partial density of states spectra indicate that the occupied states of the valence band are mainly provided by the Bi 6p orbitals. Additionally, the unoccupied states of the conduction band are always provided by the Sb 5p orbitals and Bi 6p orbitals. For Sbn/Bin LHSs, the absorption edge along XX and YY directions move toward the long wavelength direction. These results provide an approach for the applications of two-dimensional materials in near-infrared devices.
Association of nighttime physical activity with all-cause and cardiovascular mortality: Results from the NHANES
Authors: Yi Jiayi , Wang Lili , Guo Jiajun , Sun Ping , Shuai Ping , Ma Xiaoxiang , Zuo Xiaojiao , Liu Yuping , Wan Zhengwei 
Published: August 2022

BackgroundNighttime physical activity (PA) has significant effects on human health. Whether excessive nighttime PA is associated with adverse long-term prognosis remains unknown.MethodsThree thousand six hundred ninety adults from the US National Health and Nutrition Examination Survey (NHANES) 2003–2006 with accelerometer monitor recording PA data were included. Nighttime PA was quantified by the nighttime to all-day PA intensity ratio (NAPAIR). Participants with the NAPAIR above the population median (0.17) were defined as the nighttime active population (NAP), otherwise as the daytime active population. All-cause and cardiovascular disease mortality status was acquired from the US National Death Index from their interview and physical examination date through December 31, 2015.ResultsAmong 3690 adults (weighted mean age 48.1 years), 1781 (weighted proportion 48.8%) were females. One thousand eight hundred six (48.9%) were determined as the NAP. During the follow-up period of up to 13.1 years (median, 10.7 years), 639 deaths occurred (heart diseases, 114). Multivariable Cox proportional hazards model showed that the NAP was associated with higher risks of all-cause (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.22–1.75) and cardiovascular disease (HR, 1.58; 95% CI, 1.03–2.41) mortality compared with the daytime active population, and each 0.1 increase in the NAPAIR was associated with 15% increased all-cause mortality risks.ConclusionIn this nationally representative prospective cohort study of a sample of United States adults, excessive nighttime PA was associated with a higher risk of death from all causes and cardiovascular disease.
The prognostic value of pre-operative coronary evaluation in kidney transplanted patients
Authors: Steinmetz Tali , Perl Leor , Zvi Benaya Rozen , Atamna Mohamad , Kornowski Ran , Shiyovich Arthur , Hamdan Ashraf , Nesher Eviatar , Rahamimov Ruth , Gal Tuvia Ben , Skalsky Keren 
Published: August 2022

AimsNon-invasive coronary assessment using single-photon emission computerized tomography (SPECT) testing for potential cardiac ischemia is an essential part of the evaluation of kidney transplant candidates. We aimed to examine the prognostic value of preoperative SPECT test results in kidney transplanted patients.Methods and resultsWe retrospectively analyzed the pre-surgical nuclear SPECT test results in a registry of kidney transplanted patients. Follow-up at 1 month and 1 year recorded major adverse cardiac events (MACE) including non-fatal myocardial infarction, all-cause mortality and hospitalization due to cardiovascular disease following the renal transplantation. Of 577 patients available for analysis, 408 (70.9%) patients underwent nuclear SPECT test pre-transplant and 83 (20.3%) had abnormal results with either evidence of ischemia or infarct. A significantly higher incidence of post-operative MACE at 1 month was evident among patients with abnormal SPECT test compared to patients with no evidence of ischemia (10.8 vs. 4.3% respectively; P = 0.019). Differences were mostly derived from significantly increased rates of myocardial infarction events (8.4 vs. 1.8%; P = 0.002). Yet, MACE rate was not statistically different at 1 year (20.5 vs. 13.1%; P = 0.88). Importantly, the prognostic impact of an abnormal SPECT was significantly attenuated for all outcomes following multivariable adjusting for conventional cardiovascular risk factors and coronary revascularization.ConclusionPre-surgical cardiac risk assessment of kidney transplant candidates with nuclear SPECT test was found to be predictive of post-operative MACE, yet apparently, its prognostic value was significantly attenuated when adjusted for cardiac risk factors.
On the Contributions of the Northeast Cold Vortex to the Formation and Evolution of Backflow Blizzard
Authors: Yan Qi , Cui Jin , Tan Zhenghua , He Bao-Jie 
Published: August 2022

Blizzard is a severe weather-related disaster with significant environmental, economic, and social impacts. What is worse, the blizzard is increasingly frequent along with climate change. To enhance resilience, it is important to accurately estimate the blizzards. While some studies have reported the blizzard formation and characteristics, limited studies have not well presented the backflow blizzard associated with the cold vortex in Northeast China. In order to overcome this research gap, this study aims to analyze the characteristics of a backflow blizzard in Liaoning, China, and reveal the reasons behind the spatial heterogeneity of snowstorm intensity and duration. With observation data and mesoscale numerical simulation, this study discovered that the northeast cold vortex was the combined results of airflows from the Sea of Japan transported by the easterly airflow, the East China Sea, and the Yellow Sea transported by the southeast airflow, and the low-level southwest airflow, and the vortex was an important driver to the blizzard. Results further indicate that the interactions of airflow movement, water vapor variation, and frontogenesis occurrence at different layers caused the differences in snowfall intensity, duration, and volume at Zhangwu and Huanren stations. In particular, at Zhangwu station, there was an interaction of warm-wet and cold-dry airflows, but low-layer water vapor content was small, under which background only the cold air pushed the warm air as the southwest wind did not increase significantly, leading warm-humid air to be forced to climb and resulting in frontogenesis at 700–925 hPa. Therefore, the situation of no frontogenesis and poor humidity conditions in the low-level cold air contributed to the weak and a short-duration of snowfall at Zhangwu Station. The water vapor content of warm-wet and cold-wet airflows over Huanren station was better than that at Zhangwu so that during cold and warm air interaction, there was frontogenesis at 500–925 hPa. Near the top of the inverted trough in the ground layer, there was a convergence of the southeasterly wind and the northeasterly winds, resulting in the occurrence of horizontal frontogenesis throughout the layer of 500 hPa and forming an upward movement column. Moreover, a deep near-saturated water vapor layer formed below 600 hPa due to the upward movement column. Overall, the abundant water vapor combined with the deep dynamic uplift led to the heavy and long duration of snowfall at the Huanren station. Overall, this study is an important reference for understanding the backflow blizzard and its mechanism. Moreover, it is conducive to the accurate estimation of backflow blizzards in Northeast China and eastern China, the eastern coast of the Korean peninsula, and other similar areas where on the east part of the continent is the ocean.
Mendelian randomization supports the causal role of fasting glucose on periodontitis
Authors: Wang Yi , Chu Tengda , Gong Yixuan , Li Sisi , Wu Lixia , Jin Lijian , Hu Rongdang , Deng Hui 
Published: August 2022

PurposeThe effect of hyperglycemia on periodontitis is mainly based on observational studies, and inconsistent results were found whether periodontal treatment favors glycemic control. The two-way relationship between periodontitis and hyperglycemia needs to be further elucidated. This study aims to evaluate the causal association of periodontitis with glycemic traits using bi-directional Mendelian randomization (MR) approach.MethodsSummary statistics were sourced from large-scale genome-wide association study conducted for fasting glucose (N = 133,010), HbA1c (N = 123,665), type 2 diabetes (T2D, N = 659,316), and periodontitis (N = 506,594) among European ancestry. The causal relationship was estimated using the inverse-variance weighted (IVW) model and further validated through extensive complementary and sensitivity analyses.ResultsOverall, IVW showed that a genetically higher level of fasting glucose was significantly associated with periodontitis (OR = 1.119; 95% CI = 1.045–1.197; PFDR= 0.007) after removing the outlying instruments. Such association was robust and consistent through other MR models. Limited evidence was found suggesting the association of HbA1C with periodontitis after excluding the outliers (IVW OR = 1.123; 95% CI = 1.026–1.229; PFDR= 0.048). These linkages remained statistically significant in multivariate MR analyses, after adjusting for body mass index. The reverse direction MR analyses did not exhibit the causal association of genetic liability to periodontitis with any of the glycemic trait tested.ConclusionsOur MR study reaffirms previous findings and extends evidence to substantiate the causal effect of hyperglycemia on periodontitis. Future studies with robust genetic instruments are needed to confirm the causal association of periodontitis with glycemic traits.
A systematic review and meta-analysis of endocrine-related adverse events associated with interferon
Authors: Wang Linghuan , Li Binqi , Zhao He , Wu Peixin , Wu Qingzhen , Chen Kang , Mu Yiming 
Published: August 2022

ObjectivesTo perform a systematic review and meta-analysis of interferon and endocrine side effects, including their incidence, evaluation, and management.MethodsPubMed was searched through March 7th, 2021, by 2 authors independently (LH Wang and H Zhao). Early phase I/II, phase III experimental trials, prospective and retrospective observational studies were included. Stata 16.0 (StataCorp LLC, 16.0) was the main statistical software for meta-analysis. The weighted incidence and risk ratio were estimated for primary thyroid disease and diabetes mellitus.ResultsA total of 108 studies involving 46265 patients were included. Hypothyroidism was the most common thyroid disorder, followed by hyperthyroidism. IFN α+RBV treated patients experienced hypothyroidism in 7.8% (95%CI, 5.9-9.9), which was higher than IFN α (5.2%; 95%CI, 3.7-6.8) and IFN β (7.0%; 95%CI, 0.06-23.92). IFN α+RBV treated patients experienced hyperthyroidism in 5.0% (95%CI, 3.6-6.5), which was higher than IFN α (3.5%; 95%CI, 2.5-4.8) and IFN β (3.4%; 95%CI, 0.9-7.5). The summary estimated incidence of painless thyroiditis was 5.8% (95%CI, 2.8-9.8) for IFN α, and 3.5% (95%CI,1.9-5.5) for IFN α+RBV. The summary estimated incidence of diabetes was 1.4% (95%CI, 0.3-3.1) for IFN, 0.55% (95%CI, 0.05-1.57) for IFN α, 3.3% (95%CI,1.1-6.6) for IFN α+RBV.ConclusionsOur meta-analysis shows a high incidence of endocrine adverse events provoked by IFN, further reinforced by combined RBV treatment.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022334131.
Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice
Authors: Wang Tingting , Wu Limin , Chen Qiuying , Chen Kuiyu , Tan Fang , Liu Jiabo , Liu Xiang , Han Hui 
Published: August 2022

Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism characterized by liver and central nervous system dysfunction. Considerable evidence suggests that infertility is also very common in male patients with WD, but the exact molecular mechanisms involved remain unknown. In order to further investigate the pathological changes in the hypothalamic-pituitary-testicular (HPT) axis and its mechanisms, mice were divided into the normal control group (NC), WD model TX mice group (WD), dimercaptosuccinic acid–treated TX mice group (DMSA), and pregnant horse serum gonadotropin–treated TX mice group (PMSG). The copper content and morphology of hypothalamus and pituitary tissues, the ultrastructure and apoptosis of hypothalamus neurons and pituitary gonadotropin cells, the serum levels of reproductive hormones, and the pregnancy rate and litter size of the female mice were studied. The expression of apoptosis-related proteins and the phosphorylation of extracellular regulatory protein kinase (ERK) 1/2 in the hypothalamus and pituitary were detected. The results showed that the copper content was significantly increased in the WD group, and the histopathological morphology and ultrastructure of the hypothalamus and pituitary were damaged. The levels of the gonadotropin-releasing hormone, the follicle-stimulating hormone, the luteinizing hormone, and testosterone were significantly decreased. The apoptosis rate in the hypothalamus and pituitary was significantly increased. The expressions of proapoptotic proteins Bax and Caspase-3 were significantly increased, the expression of the anti-apoptotic protein Bcl-2 was significantly decreased, and the phosphorylation level of ERK1/2 was significantly decreased. Fertility is significantly reduced. After DMSA intervention, the hypothalamus tissue copper content decreased, the hypothalamus and pituitary tissue morphology and ultrastructure were improved, cell apoptosis was alleviated, the expression of Bax and Caspase-3 was significantly decreased, the expression of Bcl-2 was significantly increased, and the reproductive hormone level, phosphorylation level, and fertility were increased. Fertility was preserved after treatment with PMSG in male TX mice. These results suggest that copper deposition in WD causes male fertility decline by impairing reproductive neuroendocrine hormone release through inducing apoptosis and inhibiting the ERK signal in the hypothalamic–pituitary region. This study can also provide reference for the damage of copper pollution to the male reproductive system.