bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRO KONTRA PROSES PEMBENTUKAN UNDANG-UNDANG NOMOR 19 TAHUN 2019 TENTANG KOMISI PEMBERANTASAN KORUPSI DI TINJAU DARI AZAS-AZAS PEMBENTUKAN PERUNDANG-UNDANGAN
Authors: Ariani Devi , Liany Lusy 
Published: July 2022

Proses pembentukan Undang-Undang Nomor 19 Tahun 2019 tentang Komisi Pemberantasan Korupsi (KPK) tidak terlepas dari Pro Kontra yang dianggap bertentangan dengan Undang-Undang Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan. Dimana dalam pembentukan dan hingga akhir disahkan berlangsung dengan cepat itulah yang menjadi polemik apakah sudah dibentuk melalui prosedural yang baik. Berdasarkan latar belakang diatas penulis yang menjadi rumusan masalah: Pertama, asas-asas pembentukan peraturan Perundang-Undangan yang Baik ditinjau dari Undang-Undang Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan Kedua, proses pembentukan Undang-Undang Nomor 19 tahun 2019 tentang Komisi Pemberantasan Korupsi (KPK) di tinjau dari Undang-Undang Nomor 12 Tahun 2011 tentang pembentukan Peraturan Perundang-undangan Metode penelitian yang digunakan berupa penelitian yuridis normatif yang biasa disebut dengan pendekatan perundang-undangan dengan menggunakan data sekunder yang berupa bahan hukum primer, sekunder dan tersier. Adapun hasil pembahasannya: pertama,pembentukan Undang-Undang Nomor 19 Tahun 2019 telah melanggar asas kedayagunaan dan kehasilgunaan, asas kejelasan rumusan dan asas keterbukaan. Kedua, dalam pembentukan undang-undang tidak memenuhi syarat formil dan pemberlakuan undang-undangan dalam tata cara pembentukan peraturan perundang-undangan. Kedepannya diharapkan pemerintah selaku lembaga pembentukan undang-undang harus sesuai dengan asas-asas pembentukan peraturan undang-undang yang baik, terutama asas keterbukaan dan memuat sesuai prosedural Undang-Undang Nomor 12 tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan yang telah di revisi menjadi Undang-Undang Nomor 15 Tahun 2019 Tentang Pembentukan Peraturan Perundang-undangan
KESESUAIAN KARAKTERISTIK ANTARA PERKARA PERSAINGAN USAHA DAN PENGADILAN NIAGA
Authors: Yusuf Chandra 
Published: July 2022

Perbaikan dari suatu peraturan wajib diikuti dengan materi yang sesuai dengan peristiwa kongkritnya. Dalam perkara persaingan usaha yang diputus oleh Komisi Pengawas Persaingan Usaha berdasarkan Undang-Undang Nomor 5 Tahun 1999 tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat, pelaku usah dapat mengajukan upaya banding, yang diatur lebih lanjut dalam Peraturan Mahkamah Agung Nomor 3 Tahun 2019 tentang Tata Cara Pengajuan dan Pemeriksaan Keberatan Terhadap Putusan Komisi Pengawas Persaingan Usaha Di Pengadilan Niaga. Dalam peraturannya, pengajuan keberatan diajukan ke Pengadilan Negeri. Setelah Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja, keberatan diajukan ke Pengadilan Niaga yang diatur dalam Peraturan Mahkamah Agung Nomor 3 Tahun 2021 tentang Tata Cara Pengajuan dan Pemeriksaan Keberatan Terhadap Putusan Komisi Pengawas Persaingan Usaha Di Pengadilan Niaga. Pendekatan yang digunakan dalam penulisan ini menggunakan ppendekatan normati yuridis. Dilihat dari pendekatan tersebut, karakter dari perkara persaingan usaha tidak dapat tercakup dalam perkara yang sederhana. Apabila perkara persaingan usaha dipaksakan diselesaikan di Pengadilan Niaga, maka Hakim di Pengadilan Niaga akan memiliki masalah pembuktian yang rumit atau tidak sederhana nantinya.
KEPASTIAN HUKUM HAK ATAS TANAH MASYARAKAT HUKUM ADAT YANG MASUK DALAM KAWASAN HUTAN
Authors: Togatorop Marulak , Hardiansyah Moh. , Muzak Dawam 
Published: July 2022

Masyarakat hukum adat adalah istilah resmi yang diatur dalam berbagai peraturan perundang-undangan, seperti dalam Undang-Undang Nomor 5 Tahun 1960 Tentang Peraturan Dasar Pokok-Pokok Agraria, Undang-Undang Nomor 41 Tahun 1999 Tentang Kehutanan, dan Undang-Undang Nomor 39 Tahun 2014 Tentang Perkebunan dan peraturan perundang-undangan lainnya sebagai padanan dari rechtgemeenschapt. Tanah mempunyai kedudukan yang sangat penting dalam kehidupan manusia terutama bagi masyarakat Hukum Adat. Hubungan antara tanah dengan masyarakat itu sendiri senantiasa terjadi dalam berbagai kepentingan. Karena pentingnya tanah bagi masyarakat hukum adat sehingga pemerintah mengatur ketentuannya, akan tetapi ketentuan tersebut mengalami Antinomy Normen (Konflik Norma). Karena terjadinya Antinomy Normen (Konflik Norma) telah menunjukan ketidakpastian hukum dalam pelaksanaan pengakuan hak masyarakat khsususnya masyarakat hukum adat atas tanah yang masuk dalam kawasan hutan sehingga berimplikasi pada penerapan unsur tindak pidana. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif yaitu penelitian yang mengacu pada norma hukum yang terdapat dalam perundang-undangan dan putusan pengadilan serta norma-norma yang hidup dan berkembang dalam masyarakat. Hasil dari penelitian diperlukan adanya harmonisasi antara Kementerian/Lembaga serta harmonisasi regulasi. Selain itu, adanya Peraturan Pemerintah Nomor 43 Tahun 2021 memberikan solusi penyelesaian yang lebih menekankan kepada prinsip administrasi daripada pengenaan pidana sebagaimana upaya penyelesaian administrasi ini mempertegas ketentuan Peraturan Presiden Nomor 88 Tahun 2017.
In Vitro Measurements of True Digestibility and Products of Digestion Using Multiple Cultivars of Non-Extracted and CBD-Extracted Industrial Hemp Biomass (Cannabis sativa)
Authors: Altman A.W. , Vanzant E.S. , McLeod K.R. , Harmon D.L. 
Published: July 2022

Since 2018, the growth of industrial hemp (Cannabis sativa) for extraction of cannabidiol (CBD) oil has increased in popularity. By-products resulting from the extraction of the oil have become more available but remain largely unutilized due to their novelty and current restrictions on animal feeding. One potential use for the leftover inflorescence may be as a feedstuff, but reports examining its nutrient quality are limited. Therefore, experiments were conducted to evaluate 9 cultivars of non-extracted and 9 separate cultivars of CBD-extracted foliage. Ground alfalfa cubes were included in experiments as a control. All samples were analyzed for ash, ether extract, crude protein, lignin, ash-free neutral detergent fiber, acid detergent insoluble crude protein, and neutral detergent insoluble crude protein. Total digestible nutrients (TDN) were calculated using summative equations. In vitro true digestibility (IVTD) was determined using a filter bag technique and 48-h digestion period. Cumulative gas production was measured in batch culture over a 48-h period, with methane and ammonia production, volatile fatty acid (VFA) formation, and dry matter disappearance (DMD) measured following this period. Substrates for gas production measurements were composed of the hemp sample, rye silage, and ground corn mixed at a 30:35:35 ratio. Grind size (0.5 vs. 2.0 mm) was evaluated using non-extracted hemp and did not influence IVTD. Nutrient composition ranges of non- and CBD-extracted samples were similar, except for a numerically higher mean ether extract (17.66% vs. 9.29%) and TDN (73.01% vs. 54.03%) in non-extracted hemp. None of the measured nutrients for alfalfa cubes fell within the observed concentration ranges of either hemp group, but TDN was numerically similar to that of CBD-extracted hemp. IVTD was numerically similar between both hemp groups and alfalfa cubes. In comparison to alfalfa cubes, VFA (both concentration and molar proportions), ammonia concentrations, pH, DMD, methane, and total gas production were numerically similar with concurrently run non- and CBD-extracted hemp groups. The results of this study serve as a foundation from which a larger database of nutrient component values for hemp may be compiled. Such databases are necessary to fully evaluate the feasibility of a feedstuff for inclusion in animal diets.
Two-Photon Polymerization of 2.5D and 3D Microstructures Fostering a Ramified Resting Phenotype in Primary Microglia
Authors: Sharaf Ahmed , Roos Brian , Timmerman Raissa , Kremers Gert-Jan , Bajramovic Jeffrey John , Accardo Angelo 
Published: July 2022

Microglia are the resident macrophages of the central nervous system and contribute to maintaining brain’s homeostasis. Current 2D “petri-dish”in vitrocell culturing platforms employed for microglia, are unrepresentative of the softness or topography of native brain tissue. This often contributes to changes in microglial morphology, exhibiting an amoeboid phenotype that considerably differs from the homeostatic ramified phenotype in healthy brain tissue. To overcome this problem, multi-scale engineered polymeric microenvironments are developed and tested for the first time with primary microglia derived from adult rhesus macaques. In particular, biomimetic 2.5D micro- and nano-pillar arrays (diameters = 0.29–1.06 µm), featuring low effective shear moduli (0.25–14.63 MPa), and 3D micro-cages (volume = 24 × 24 × 24 to 49 × 49 × 49 μm3) with and without micro- and nano-pillar decorations (pillar diameters = 0.24–1 µm) were fabricated using two-photon polymerization (2PP). Compared to microglia cultured on flat substrates, cells growing on the pillar arrays exhibit an increased expression of the ramified phenotype and a higher number of primary branches per ramified cell. The interaction between the cells and the micro-pillar-decorated cages enables a more homogenous 3D cell colonization compared to the undecorated ones. The results pave the way for the development of improved primary microgliain vitromodels to study these cells in both healthy and diseased conditions.
Rheological Properties of Cement-Modified Asphalt Binders
Authors: Al-Khateeb Ghazi , Ghuzlan Khalid , Ismail Mohammed , Shabib Ahmad , Naeem Marwan , Elbaz Yousef 
Published: July 2022

Asphalt pavements are subjected to major distresses like fatigue, rutting, and low-temperature cracking due to repeated traffic loading and climatic conditions. The modification of the asphalt binder (a major component of an asphalt paving mixture) using additives helps in minimizing the possibility of pavement distresses. The cement additive was used in this study at cement-to-asphalt (C/A) percentages of 0, 10, and 20% by volume. The main objective of the study was to investigate the impact of C/A percentage, temperature, and loading frequency on the rutting resistance of asphalt binders using statistical analysis. Two aging conditions were also used: unaged condition and short-term aging condition in the rolling thin-film oven (RTFO). The dynamic shear rheometer (DSR) test was used to characterize the asphalt binders at ten loading frequencies (0.1, 0.3, 0.6, 1, 1.59, 3, 5, 7, 8, and 10 Hz) and four temperatures (58, 64, 70, and 76°C). These combinations were used to cover a wide range of combined conditions and to follow the high-temperature range for the Superpave performance grade (PG) system. Multiple statistical analyses [the one-way analysis of variance (ANOVA) and correlation tests] were performed to identify the relation between the tested variables and the rutting parameter (G*/sinδ). Findings of the study have shown that the loading frequency has a significant effect on the rutting parameter for unaged and RTFO-aged asphalt binders under different temperatures and using different C/A percentages. Regression analysis was conducted to depict an accurate model that can predict the rutting parameter (G*/sinδ) for each aging condition. Based on the regression analysis, nonlinear power models were developed for the rutting parameter of four groups: unaged unmodified, unaged cement-modified, RTFO-aged unmodified, and RTFO-aged cement-modified asphalt binders with the coefficient of determination (R2) values of 0.986, 0.986, 0.996, and 0.992, respectively. The ANOVA test results showed that the cement addition (represented by the C/A percentage) had a significant impact on the rutting parameter of cement-modified asphalt binders for both aging groups. Furthermore, the correlation tests conducted in this study showed that the temperature and loading frequency had significant effects in the predictive models of the rutting parameter of unmodified asphalt binders and that the temperature, loading frequency, and C/A percentage had significant effects in the predictive models of the cement-modified asphalt binders.
TiO2 NPs/h-BN: Preparation and catalytic activities of a novel AP catalyst
Authors: Zhao Jun , Deng Nengmei 
Published: July 2022

The thermal decomposition performance of an oxidizer directly determines the thrust and specific impulse properties of the solid propellant. Hexagonal boron nitride (h-BN) has the characteristics of high catalytic activity and good stability, which can improve the heat release and decomposition temperature of the oxidant, and then improve the energy performance of the propellant. In this study, a novel hybrid material TiO2 NPs/h-BN was successfully prepared by in situ growth, and it was found that when 5 wt.% TiO2 NPs/h-BN was added, the initial decomposition temperature of ammonium perchlorate (AP) decreased by 67.6°C. Due to the addition of TiO2, the gap between the h-BN layers as well as the specific surface increased, which optimized its thermocatalytic performance, and it also proposed a catalytic mechanism for the thermal decomposition process of AP.
Case report: Changes in the levels of stress hormones during Takotsubo syndrome
Authors: Ruiz Pablo , Gabarre Paul , Chenevier-Gobeaux Camille , François Hélène , Kerneis Mathieu , Cidlowski John A. , Oakley Robert H. , Lefèvre Guillaume , Boissan Mathieu 
Published: July 2022

BackgroundTakotsubo syndrome is an acute cardiac condition usually involving abnormal regional left ventricular wall motion and impaired left ventricular contractility. It is due mainly to hyper-stimulation of the sympathetic nerve system, inducing an excess of catecholamines, usually triggered by intense psychological or physiological stress. The relationship between Takotsubo syndrome and the circulating stress hormones cortisol and copeptin (a surrogate marker of arginine vasopressin) has not been well documented.Case summaryHere, we describe the dynamic changes in circulating cortisol and copeptin during an entire episode of Takotsubo syndrome in a post-partum woman after spontaneous vaginal delivery. The patient was diagnosed with inverted Takotsubo syndrome accompanied by HELLP syndrome. We found qualitative and quantitative changes in cortisol: a loss of circadian rhythm and a three-fold elevation in the plasma concentration of the hormone with a peak appearing several hours before circulating cardiac biomarkers began to rise. By contrast, levels of copeptin remained normal during the entire episode.DiscussionOur findings indicate that the levels of cortisol change during Takotsubo syndrome whereas those of copeptin do not. This association between elevated cortisol and Takotsubo syndrome suggests that aberrant levels of this stress hormone may contribute to the observed cardiac pathology. We conclude that biochemical assays of circulating cortisol and cardiac biomarkers may be a useful complement to the diagnosis of Takotsubo syndrome by non-invasive cardiac imaging.
Predictors of late arrhythmic events after generator replacement in Brugada syndrome treated with prophylactic ICD
Authors: Migliore Federico , Martini Nicolò , Calo' Leonardo , Martino Annamaria , Winnicki Giulia , Vio Riccardo , Condello Chiara , Rizzo Alessandro , Zorzi Alessandro , Pannone Luigi , Miraglia Vincenzo , Sieira Juan , Chierchia Gian-Battista , Curcio Antonio , Allocca Giuseppe , Mantovan Roberto , Salghetti Francesca , Curnis Antonio , Bertaglia Emanuele , De Lazzari Manuel , de Asmundis Carlo , Corrado Domenico 
Published: July 2022

IntroductionPredictors of late life-threatening arrhythmic events in Brugada syndrome (BrS) patients who received a prophylactic ICD implantation remain to be evaluated. The aim of the present long-term multicenter study was to assess the incidence and clinical-electrocardiographic predictors of late life-threatening arrhythmic events in BrS patients with a prophylactic implantable cardioverter defibrillator (ICD) and undergoing generator replacement (GR).MethodsThe study population included 105 patients (75% males; mean age 45 ± 14years) who received a prophylactic ICD and had no arrhythmic event up to first GR.ResultsThe median period from first ICD implantation to last follow-up was 155 (128–181) months and from first ICD Implantation to the GR was 84 (61–102) months. During a median follow-up of 57 (38–102) months after GR, 10 patients (9%) received successful appropriate ICD intervention (1.6%/year). ICD interventions included shock on ventricular fibrillation (n = 8 patients), shock on ventricular tachycardia (n = 1 patient), and antitachycardia pacing on ventricular tachycardia (n = 1 patient). At survival analysis, history of atrial fibrillation (log-rank test; P = 0.02), conduction disturbances (log-rank test; P &lt; 0.01), S wave in lead I (log-rank test; P = 0.01) and first-degree atrioventricular block (log-rank test; P = 0.04) were significantly associated with the occurrence of late appropriate ICD intervention. At Cox-regression multivariate analysis, S-wave in lead I was the only independent predictor of late appropriate ICD intervention (HR: 9.17; 95%CI: 1.15–73.07; P = 0.03).ConclusionsThe present study indicates that BrS patient receiving a prophylactic ICD may experience late appropriate intervention after GR in a clinically relevant proportion of cases. S-wave in lead I at the time of first clinical evaluation was the only independent predictor of persistent risk of life-threatening arrhythmic events. These findings support the need for GR at the end of service regardless of previous appropriate intervention, mostly in BrS patients with conduction abnormalities.
Feasibility, engagement, and preliminary clinical outcomes of a digital biodata-driven intervention for anxiety and depression
Authors: Tsirmpas Charalampos , Andrikopoulos Dimitrios , Fatouros Panagiotis , Eleftheriou Georgios , Anguera Joaquin A. , Kontoangelos Konstantinos , Papageorgiou Charalabos 
Published: July 2022

HypothesisThe main hypothesis is that a digital, biodata-driven, and personalized program would exhibit high user retention and engagement, followed by more effective management of their depressive and anxiety symptoms.ObjectiveThis pilot study explores the feasibility, acceptability, engagement, and potential impact on depressive and anxiety and quality of life outcomes of the 16-week Feel Program. Additionally, it examines potential correlations between engagement and impact on mental health outcomes.MethodsThis single-arm study included 48 adult participants with mild or moderate depressive or anxiety symptoms who joined the 16-week Feel Program, a remote biodata-driven mental health support program created by Feel Therapeutics. The program uses a combination of evidence-based approaches and psychophysiological data. Candidates completed an online demographics and eligibility survey before enrolment. Depressive and anxiety symptoms were measured using the Patient Health Questionnaire and Generalized Anxiety Disorder Scale, respectively. The Satisfaction with Life Scale and the Life Satisfaction Questionnaire were used to assess quality of life. User feedback surveys were employed to evaluate user experience and acceptability.ResultsIn total, 31 participants completed the program with an overall retention rate of 65%. Completed participants spent 60 min in the app, completed 13 Mental Health Actions, including 5 Mental Health Exercises and 4.9 emotion logs on a weekly basis. On average, 96% of the completed participants were active and 76.8% of them were engaged with the sensor during the week. Sixty five percent of participants reported very or extremely high satisfaction, while 4 out of 5 were very likely to recommend the program to someone. Additionally, 93.5% of participants presented a decrease in at least one of the depressive or anxiety symptoms, with 51.6 and 45% of participants showing clinically significant improvement, respectively. Finally, our findings suggest increased symptom improvement for participants with higher engagement throughout the program.ConclusionsThe findings suggest that the Feel Program may be feasible, acceptable, and valuable for adults with mild or moderate depressive and/or anxiety symptoms. However, controlled trials with bigger sample size, inclusion of a control group, and more diverse participant profiles are required in order to provide further evidence of clinical efficacy.
Implementation of Electronic Adherence Monitors and Associated Interventions for Routine HIV Antiretroviral Therapy in Uganda: Promising Findings
Authors: Haberer Jessica E. , Baijuka Robert , Tumuhairwe John Bosco , Tindimwebwa Edna B. , Tinkamanyire James , Tuhanamagyezi Ellyk , Musoke Lawrence , Garrison Lindsey E. , DelSignore Marisa , Musinguzi Nicholas , Asiimwe Stephen 
Published: July 2022

BackgroundHigh, sustained adherence is critical for achieving the individual and public health benefits of HIV antiretroviral therapy (ART). Electronic monitors provide detailed adherence information and can enable real-time interventions; however, their use to date has largely been confined to research. This pilot study (NCT03825952) sought to understand feasibility and acceptability a relatively low-cost version of this technology and associated interventions for routine ART delivery in sub-Saharan Africa.MethodsWe provided two ART clinics in rural, southwestern Uganda with electronic adherence monitors for data-informed counseling as well as optional SMS messages to clients and/or social supporters (daily or triggered by missed or delayed doses) and/or an alarm. Clinic and ART client experiences were observed for 3 months per client, including time and motion studies. Qualitative interviews among clients, clinicians, and healthcare administrators were informed by the Consolidated Framework for Implementation Research.ResultsFifty-one ART clients were enrolled; 57% were male and the median age was 34 years. Choice of associated intervention varied among participants. The median number of visits during follow-up was two per client. Counselors reviewed the adherence data with 90% of clients at least once; 67% reviewed data at all visits. Average adherence was 94%; four clients had adherence gaps &gt;1 week. Acceptability was high; all but one client found the monitor "very useful” and all found SMS “very useful.” Clinic visits among clients with the intervention lasted 4 min longer on average than those in standard care. The monitors and daily SMS generally functioned well, although excess SMS were triggered, primarily due to cellular network delays. Overall, participants felt the technology improved adherence, clinic experiences, and clinician-client relationships. Few worried about stigma and privacy. Cost was a concern for implementation, particularly at scale.ConclusionWe successfully implemented a relatively low-cost electronic ART adherence monitor and associated interventions for routine care in rural Uganda. Feasibility and acceptability were generally high, and individuals were identified who could benefit from adherence support. Future work should involve longitudinal follow-up of diverse populations, clinical outcomes, and detailed cost-effectiveness analysis to help drive policy decisions around the uptake of this technology for routine clinical care.Clinical Trial Registrationidentifier: NCT03825952.