bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tension experience induced by tonal and melodic shift at music phrase boundaries
Authors: Zhang Ning , Sun Lijun , Wu Qiong , Yang Yufang 
Published: May 2022

AbstractMusic tension is a link between music structures and emotions. As music unfolds, developmental patterns induce various emotional experiences, but the relationship between developmental patterns and tension experience remains unclear. The present study compared two developmental patterns of two successive phrases (tonal shift and melodic shift) with repetition condition to investigate the relationship with tension experience. Professional musicians rated on-line felt tension and EEG responses were recorded while listening to music sequences. Behavioral results showed that tension ratings under tonal and melodic shift conditions were higher than those under repetition conditions. ERP results showed larger potentials at early P300 and late positive component (LPC) time windows under tonal shift condition, and early right anterior negativity (ERAN) and LPC under melodic shift condition. ERSP results showed early beta and late gamma power increased under tonal shift condition, theta power decreased and alpha power increased under melodic shift condition. Our findings suggest that developmental patterns play a vital role in tension experiences; tonal shift affects tension by tonal shift detection and integration, while melodic shift affects tension by attentional processing and working memory integration. From the perspective of Event Structure Processing Model, solid evidence was given to specify the time-span segmentation and reduction.
Targeting the translational machinery in gastrointestinal stromal tumors (GIST): a new therapeutic vulnerability
Authors: Lee Donna M. , Sun Angela , Patil Sneha S. , Liu Lijun , Rao Aparna V. , Trent Parker T. , Ali Areej A. , Liu Catherine , Rausch Jessica L. , Presutti Laura D. , Kaczorowski Adam , Schneider Felix , Amankulor Nduka M. , Shuda Masahiro , Duensing Anette 
Published: May 2022

AbstractAlthough KIT-mutant GISTs can be effectively treated with tyrosine kinase inhibitors (TKIs), many patients develop resistance to imatinib mesylate (IM) as well as the FDA-approved later-line agents sunitinib, regorafenib and ripretinib. Resistance mechanisms mainly involve secondary mutations in the KIT receptor tyrosine kinase gene indicating continued dependency on the KIT signaling pathway. The fact that the type of secondary mutation confers either sensitivity or resistance towards TKIs and the notion that secondary mutations exhibit intra- and intertumoral heterogeneity complicates the optimal choice of treatment in the imatinib-resistant setting. Therefore, new strategies that target KIT independently of its underlying mutations are urgently needed. Homoharringtonine (HHT) is a first-in-class inhibitor of protein biosynthesis and is FDA-approved for the treatment of chronic myeloid leukemia (CML) that is resistant to at least two TKIs. HHT has also shown activity in KIT-mutant mastocytosis models, which are intrinsically resistant to imatinib and most other TKIs. We hypothesized that HHT could be effective in GIST through downregulation of KIT expression and subsequent decrease of KIT activation and downstream signaling. Testing several GIST cell line models, HHT led to a significant reduction in nascent protein synthesis and was highly effective in the nanomolar range in IM-sensitive and IM-resistant GIST cell lines. HHT treatment resulted in a rapid and complete abolishment of KIT expression and activation, while KIT mRNA levels were minimally affected. The response to HHT involved induction of apoptosis as well as cell cycle arrest. The antitumor activity of HHT was confirmed in a GIST xenograft model. Taken together, inhibition of protein biosynthesis is a promising strategy to overcome TKI resistance in GIST.
Age-related changes in visuo-proprioceptive processing in perceived body position
Authors: Teramoto Wataru 
Published: May 2022

AbstractThis study investigated age-related change in visuo-proprioceptive processing in the perceived body position using mirror hand/foot illusions, focusing on its temporal characteristics, its dependency on body parts, and its association with older adults’ fall risk. Either immediately or 15 s after the exposure to the mirror-induced inconsistency of visuo-proprioceptive signals regarding the right hand or foot position, participants performed a reaching task using the unseen, illusion-affected hand or foot. Results showed clear age group differences. Specifically, older adults exhibited larger reaching errors than younger adults in the hand condition, and after the 15 s delay in the foot condition. Further, the reaching errors were constant across time for older adults but decreased after the delay in young adults, regardless of the tested body part. Particularly, older adults’ risk of falling, which was assessed by the timed up-and-go test, was negatively correlated with the reduction of reaching error across time. This suggests that older adults, especially those with a high risk of falling, face difficulties in appropriately processing visual and proprioceptive information for body perception in accordance with their external environment.
Spanish cross-cultural adaptation and validation of the Australian Pelvic Floor Questionnaire in running women
Authors: Molina-Torres Guadalupe , Guallar-Bouloc Marina , Galán-Mercant Alejandro , Kasper-Jędrzejewska Martyna , Merchán-Baeza José Antonio , Gonzalez-Sanchez Manuel 
Published: May 2022

AbstractPelvic floor dysfunctions are a wide range of disorders in the gynaecological, lower urinary and gastrointestinal tracts that affect the structure and/or function of the pelvic organs. The objective of this study was to carry out a cross-cultural adaptation and a psychometric analysis of the Spanish version of the Australian Pelvic Floor Questionnaire. Observational study divided into two main phases: (1) translation and cross-cultural adaptation and (2) psychometric tests. Women runners from all over the Spanish territory, from different federations, clubs and levels were recruited. Participants: 424 female runners, native Spanish, over 18 years of age and who had been practicing running for more than 6 months. The instruments used in this study were the Australian Pelvic Floor Questionnaire, Female Sexual Function Index, King Health Questionnaire, Quality of Life SF-12 and EuroQoL 5-D. The Spanish version of Australian Pelvic Floor Questionnaire has proven to be an understandable and easy-to-use tool. The general internal consistency of the questionnaire was 0.972 and the intraclass correlation coefficient ranged between ICC 0.596–0.960. The Spanish version of Australian Pelvic Floor Questionnaire is a valid and reliable measure that can be used clinically to assess pelvic floor dysfunctions among the female Spanish population.
Graph Ricci curvatures reveal atypical functional connectivity in autism spectrum disorder
Authors: Elumalai Pavithra , Yadav Yasharth , Williams Nitin , Saucan Emil , Jost Jürgen , Samal Areejit 
Published: May 2022

AbstractWhile standard graph-theoretic measures have been widely used to characterize atypical resting-state functional connectivity in autism spectrum disorder (ASD), geometry-inspired network measures have not been applied. In this study, we apply Forman–Ricci and Ollivier–Ricci curvatures to compare networks of ASD and typically developing individuals (N = 1112) from the Autism Brain Imaging Data Exchange I (ABIDE-I) dataset. We find brain-wide and region-specific ASD-related differences for both Forman–Ricci and Ollivier–Ricci curvatures, with region-specific differences concentrated in Default Mode, Somatomotor and Ventral Attention networks for Forman–Ricci curvature. We use meta-analysis decoding to demonstrate that brain regions with curvature differences are associated to those cognitive domains known to be impaired in ASD. Further, we show that brain regions with curvature differences overlap with those brain regions whose non-invasive stimulation improves ASD-related symptoms. These results suggest the utility of graph Ricci curvatures in characterizing atypical connectivity of clinically relevant regions in ASD and other neurodevelopmental disorders.
Atomic-scale understanding of the Na and Cl trapping on the Mo1.33C(OH)2-MXene
Authors: Guerrero-Sanchez J. , Muñoz-Pizza Dalia M. , Moreno-Armenta Ma Guadalupe , Takeuchi Noboru 
Published: May 2022

AbstractDrinking water scarcity in arid and semi-arid regions is a reality that may turn into a global healthcare problem in the next few years. The scientific community is always looking for new materials to achieve effective sea and brackish water desalination to reduce water scarcity. Commonly, theoretical, and experimental methods make a synergy to better understand and explain the chemical and physical processes in water desalination electrodes. In this way, experimental evidence pointed Mo1.33CTx MXene as an efficient ion intercalation material, in which both Na+ and Cl− are removed. However, the atomic scale understanding of the physicochemical processes due to the Na and Cl interaction with the MXene is still unknown. We report the Na0 and Cl0 interaction with an OH functionalized Mo1.33C monolayer through a comprehensive first-principles density functional theory assessment. Results demonstrate that Na atoms attach to Oxygen, whereas Cl atoms bond through hydrogen bonds to the functional groups in the MXene, these bonds have two energy contributions: electrostatic and charge transfer, which increases its adsorption energy. Electrostatic potential isosurfaces, Bader charge analysis, and non-covalent interactions index help clarifying the way Na0 and Cl0 attach to the MXene layer. Oxygen atoms have an affinity for the electropositive Na0 atoms, which after interaction oxidizes to Na+, whereas hydrogen atoms—of the hydroxyl groups—interact with the electronegative Cl0 atoms, which upon adsorption reduce to Cl−. Our findings explain why OH-functionalized Mo1.33C can efficiently remove both Na and Cl atoms based on their affinities with the functional groups present in the MXene layer.
Morphological and ultrasonographic characterization of the three zones of supratesticular region of testicular artery in Assaf rams
Authors: Hassan Mohamed A. A. , Sayed Ramy K. A. , Abdelsabour-Khalaf Mohammed , Abd-Elhafez Enas A. , Anel-Lopez L. , Riesco M. F. , Ortega-Ferrusola C. , Montes-Garrido R. , Neila-Montero M. , Anel L. , Alvarez M. 
Published: May 2022

AbstractTo fully understand the histological, morphometrical and heamodynamic variations of different supratesticular artery regions, 20 mature and healthy Assaf rams were examined through ultrasound and morphological studies. The testicular artery images of the spermatic cord as shown by B-mode analysis indicated a tortuous pattern along its course toward the testis, although it tends to be less tortuous close to the inguinal ring. Doppler velocimetric values showed a progressive decline in flow velocity, in addition to pulsatility and vessel resistivity when entering the testis, where there were significant differences in the Doppler indices and velocities among the different regions. The peak systolic velocity, pulsatility index and resistive index were higher in the proximal supratesticular artery region, followed by middle and distal ones, while the end diastolic velocity was higher in the distal supratesticular region. The total arterial blood flow and total arterial blood flow rate reported a progressive and significant increase along the testicular cord until entering the testis. Histological examination revealed presence of vasa vasorum in the tunica adventitia, with their diameter is higher in the proximal supratesticular zone than middle and distal ones. Morphometrically, the thickness of the supratesticular artery wall showed a significant decline downward toward the testis; meanwhile, the outer arterial diameter and inner luminal diameter displayed a significant increase distally. The expression of alpha smooth muscle actin and vimentin was higher in the tunica media of the proximal supratesticular artery zone than in middle and distal ones.
Optically stimulated luminescence in state-of-the-art LYSO:Ce scintillators enables high spatial resolution 3D dose imaging
Authors: Jensen Mads L. , Nyemann Jacob S. , Muren Ludvig P. , Julsgaard Brian , Balling Peter , Turtos Rosana M. 
Published: May 2022

AbstractIn this contribution, we study the optically stimulated luminescence (OSL) exhibited by commercial $$\hbox {Lu}_{(2-x)}\hbox {Y}_x\hbox {SiO}_5$$

Lu

(
2
-
x
)

Y
x

SiO
5

:Ce crystals. This photon emission mechanism, complementary to scintillation, can trap a fraction of radiation energy deposited in the material and provides sufficient signal to develop a novel post-irradiation 3D dose readout. We characterize the OSL emission through spectrally and temporally resolved measurements and monitor the dose linearity response over a broad range. The measurements show that the $$\hbox {Ce}^{3+}$$

Ce

3
+

centers responsible for scintillation also function as recombination centers for the OSL mechanism. The capture to OSL-active traps competes with scintillation originating from the direct non-radiative energy transfer to the luminescent centers. An OSL response on the order of 100 ph/MeV is estimated. We demonstrate the imaging capabilities provided by such an OSL photon yield using a proof-of-concept optical readout method. A 0.1 $$\hbox {mm}^3$$

mm
3

spatial resolution for doses as low as 0.5 Gy is projected using a cubic crystal to image volumetric dose profiles. While OSL degrades the intrinsic scintillating performance by reducing the number of scintillation photons emitted following the passage of ionizing radiation, it can encode highly resolved spatial information of the interaction point of the particle. This feature combines ionizing radiation spectroscopy and 3D reusable dose imaging in a single material.
Reduced neural investment in post-reproductive females of the bee Ceratina calcarta
Authors: Jaumann Sarah , Rehan Sandra M. , Schwartz Kayla , Smith Adam R. 
Published: May 2022

AbstractMany insects show plasticity in the area of the brain called the mushroom bodies (MB) with foraging and social experience. MBs are paired neuropils associated with learning and memory. MB volume is typically greater in mature foragers relative to young and/or inexperienced individuals. Long-term studies show that extended experience may further increase MB volume, but long-term studies have only been performed on non-reproductive social insect workers. Here we use the subsocial bee Ceratina calcarata to test the effect of extended foraging experience on MB volume among reproductive females. Ceratina calcarata females forage to provision their immature offspring in the spring, and then again to provision their adult daughters in the late summer. We measured the volume of the MB calyces and peduncle, antennal lobes (AL), optic lobes (OL), central complex (CX), and whole brains of three groups of bees: newly emerged females, reproductive females in spring (foundresses), and post-reproductive mothers feeding their adult daughters in late summer. Post-reproductive late summer mothers had smaller MB calyces and ALs than foundresses. Moreover, among late mothers (but not other bees), wing wear, which is a measure of foraging experience, negatively correlated with both MB and OL volume. This is contrary to previously studied non-reproductive social insect workers in which foraging experience correlates postiviely with MB volume, and suggests that post-reproductive bees may reduce neural investment near the end of their lives.
Influence of circulatory shock at hospital admission on outcome after out-of-hospital cardiac arrest
Authors: Düring Joachim , Annborn Martin , Dankiewicz Josef , Dupont Allison , Forsberg Sune , Friberg Hans , Kern Karl B. , May Teresa L. , McPherson John , Patel Nainesh , Seder David B. , Stammet Pascal , Sunde Kjetil , Søreide Eldar , Ullén Susann , Nielsen Niklas 
Published: May 2022

AbstractHypotension after cardiac arrest could aggravate prolonged hypoxic ischemic encephalopathy. The association of circulatory shock at hospital admission with outcome after cardiac arrest has not been well studied. The objective of this study was to investigate the independent association of circulatory shock at hospital admission with neurologic outcome, and to evaluate whether cardiovascular comorbidities interact with circulatory shock. 4004 adult patients with out-of-hospital cardiac arrest enrolled in the International Cardiac Arrest Registry 2006–2017 were included in analysis. Circulatory shock was defined as a systolic blood pressure below 90 mmHg and/or medical or mechanical supportive measures to maintain adequate perfusion during hospital admission. Primary outcome was cerebral performance category (CPC) dichotomized as good, (CPC 1–2) versus poor (CPC 3–5) outcome at hospital discharge. 38% of included patients were in circulatory shock at hospital admission, 32% had good neurologic outcome at hospital discharge. The adjusted odds ratio for good neurologic outcome in patients without preexisting cardiovascular disease with circulatory shock at hospital admission was 0.60 [0.46–0.79]. No significant interaction was detected with preexisting comorbidities in the main analysis. We conclude that circulatory shock at hospital admission after out-of-hospital cardiac arrest is independently associated with poor neurologic outcome.
Long-term clinical course and progression of lymphangioleiomyomatosis in a single lung transplant referral centre in Korea
Authors: Chang Shihwan , Choi Ji Soo , Leem Ah Young , Lee Su Hwan , Lee Sang Hoon , Kim Song Yee , Chung Kyung Soo , Jung Ji Ye , Kang Young Ae , Kim Young Sam , Lee Jin Gu , Paik Hyo Chae , Shim Hyo Sup , Lee Eun Hye , Park Moo Suk 
Published: May 2022

AbstractWe aimed to describe the clinical features of lymphangioleiomyomatosis (LAM) in Korean patients and identify factors associated with progressive disease (PD). Clinical features of 54 patients with definite or probable LAM from 2005 to 2018 were retrospectively analysed. Common features were pneumothorax (66.7%) and abdominal lymphadenopathy (50.0%). Twenty-three (42.6%) patients were initially treated with mechanistic target of rapamycin (mTOR) inhibitors. Lung transplantation (LT) was performed in 13 (24.1%) patients. Grouped based on the annual decline in forced expiratory volume in 1 s (FEV1) from baseline and LT, 36 (66.7%) patients exhibited stable disease (SD). All six deaths (11.1%) occurred in PD. Proportion of SD was higher in those treated initially with mTOR inhibitors than in those under observation (p = 0.043). Univariate analysis revealed sirolimus use, and baseline forced vital capacity, FEV1, and diffusing capacity of the lungs for carbon monoxide are associated with PD. Multivariate analysis showed that only sirolimus use (odds ratio 0.141, 95% confidence interval 0.021–0.949, p = 0.044) reduced PD. Kaplan–Meier analysis estimates overall survival of 92.0% and 74.7% at 5 and 10 years, respectively. A considerable proportion of LAM patients remain clinically stable without treatment. LT is an increasingly viable option for patients with severe lung function decline.
Assessing the pathogenicity of gut bacteria associated with tobacco caterpillar Spodoptera litura (Fab.)
Authors: Devi Sarita , Saini Harvinder Singh , Kaur Sanehdeep 
Published: May 2022

AbstractThe symbiotic relationship between insects and gut microbes contributes to their fitness by serving immense range of functions viz. nutrition and digestion, detoxification, communication and reproduction etc. However, this relationship between insect and gut microbes varies from mutualistic to pathogenic. Gut microbes become pathogenic when the healthy normal microbial composition is perturbed leading to the death of insect host. Spodoptera litura (Fab.) is a polyphagous pest that causes significant damage to many agricultural crops. The management of this pest primarily depends upon chemical insecticides which have resulted in development of resistance. Thus in search for alternative strategies, culturable gut bacteria isolated from S. litura were screened for insecticidal potential. Among these Serratia marcescens and Enterococcus mundtii induced higher larval mortality in S. litura. The mortality rate increased from 32 to 58% due to S. marcescens at concentrations ranging from 2.6 × 108 to 5.2 × 109 cfu/ml and 26 to 52% in case of E. mundtii due to increase in concentration from 4.6 × 108 to 6.1 × 109 cfu/ml. Both the bacteria negatively affected the development, nutritional physiology and reproductive potential of insect. The results indicated a change in gut microbial composition as well as damage to the gut epithelial membrane. Invasion of gut bacteria into the haemocoel led to septicaemia and ultimately death of host insect. In conclusion both these gut bacteria may serve as potential biocontrol agents against S. litura.
Octahedral oxide glass network in ambient pressure neodymium titanate
Authors: Wilke Stephen K. , Alderman Oliver L. G. , Benmore Chris J. , Neuefeind Jörg , Weber Richard 
Published: May 2022

AbstractRare-earth titanates form very fragile liquids that can be made into glasses with useful optical properties. We investigate the atomic structure of 83TiO2-17Nd2O3 glass using pair distribution function (PDF) analysis of X-ray and neutron diffraction with double isotope substitutions for both Ti and Nd. Six total structure factors are analyzed (5 neutron + 1 X-ray) to obtain complementary sensitivities to O and Ti/Nd scattering, and an empirical potential structure refinement (EPSR) provides a structural model consistent with the experimental measurements. Glass density is estimated as 4.72(13) g cm−3, consistent with direct measurements. The EPSR model indicates nearest neighbor interactions for Ti-O at $$\overline{r}_{TiO}$$

r
¯

TiO

= 1.984(11) Å with coordination of $$n_{TiO}$$

n

TiO

= 5.72(6) and for Nd-O at $$\overline{r}_{NdO}$$

r
¯

NdO

= 2.598(22) Å with coordination of $$n_{NdO}$$

n

NdO

= 7.70(26), in reasonable agreement with neutron first order difference functions for Ti and Nd. The titanate glass network comprises a mixture of distorted Ti-O5 and Ti-O6 polyhedra connected via 71% corner-sharing and 23% edge-sharing. The O-Ti coordination environments include 15% nonbridging O-Ti1, 51% bridging O-Ti2, and 32% tricluster O-Ti3. This structure is highly unusual for oxide glasses melt-quenched at ambient pressure, as it consists of Ti-Ox predominantly in octahedral (with nearly no tetrahedral) coordination.
Surgical resection could provide better outcomes for patients with hepatocellular carcinoma and tumor rupture
Authors: Lee Chun-Yang , Chau Gar-Yang , Wei Cheng-Yi , Chao Yee , Huang Yi-Hsiang , Huo Teh-Ia , Hou Ming-Chih , Su Yu-Hui , Wu Jaw-Ching , Su Chien-Wei 
Published: May 2022

AbstractWe investigated the outcomes of patients with ruptured hepatocellular carcinoma (HCC) and identified the optimal treatment modality for such patients. We retrospectively enrolled 91 patients with treatment-naive HCC and tumor rupture at diagnosis, including 38 patients who underwent surgical resection (SR) alone, 28 patients who were treated with transarterial chemoembolization (TACE) only, 20 patients who had a sequential combination therapy of TACE and SR, and 5 patients who received best supportive care. After a median follow-up of 13.1 months, 54 patients died. The cumulative 5 years overall survival (OS) rates were 55.1% and 0% in the SR group and non-SR group, respectively (p < 0.001). Non-SR therapy was associated with poorer OS according to a multivariate analysis with a hazard ratio of 6.649 (95% confidence interval 3.581–12.344, p < 0.001). Moreover, whether patients received TACE or not did not impact the OS in both the SR group and the non-SR group. In conclusion, for patients with HCC and tumor rupture at the time of diagnosis, SR could lead to better prognoses than non-surgery treatment modalities. Moreover, a sequential combination of TACE and SR had similar clinical outcomes when compared to SR alone.