bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical site infection after laparoscopic resection of colorectal cancer is associated with compromised long-term oncological outcome
Authors: Sugamata Nana , Okuyama Takashi , Takeshita Emiko , Oi Haruka , Hakozaki Yuhei , Miyazaki Shunya , Takada Musashi , Mitsui Takashi , Noro Takuji , Yoshitomi Hideyuki , Oya Masatoshi 
Published: April 2022

Abstract
Background
We evaluated the influence of infectious complications, particularly surgical site infection (SSI), on long-term oncological results after elective laparoscopic resection of colorectal cancer.

Methods
A total of 199 patients who underwent laparoscopic elective resection with negative resection margins for stage I–III colorectal cancer were retrospectively examined. The postoperative course was recorded based on hospital records, and cancer relapse was diagnosed based on radiological or pathological findings under a standardized follow-up program. The severity of complications was graded using Clavien-Dindo (CD) classification.

Results
SSI was found in 25 patients (12.6%), with 12 (6.0%) showing anastomotic leak. The postoperative relapse-free survival (RFS) rate was significantly lower in patients with SSI (49.2%) than in patients without SSI (87.2%, P<0.001). Differences in RFS were found after both colectomy and rectal resection (P<0.001 and P<0.001, respectively). RFS did not differ between patients who had major SSI CD (grade III) and those who had minor SSI CD (grades I or II). Multivariate Cox regression analysis identified the occurrence of SSI and pathological stage as independent co-factors for RFS (P<0.001 and P=0.003).

Conclusion
These results suggest that postoperative SSI compromises long-term oncological results after laparoscopic colorectal resection. Further improvements in surgical technique and refinements in perioperative care may improve long-term oncological results.
GLA:D® Back Australia: a mixed methods feasibility study for implementation
Authors: Fernandez Matthew , Young Anika , Kongsted Alice , Hartvigsen Jan , Barton Christian , Wallis Jason , Kent Peter , Kawchuk Greg , Jenkins Hazel , Hancock Mark , French Simon D. 
Published: April 2022

Abstract
Background
Practice-based guidelines recommend patient education and exercise as first-line care for low back pain (LBP); however, these recommendations are not routinely delivered in practice. GLA:D® Back, developed in Denmark to assist clinicians to implement guideline recommendations, offers a structured education and supervised exercise program for people with LBP in addition to a clinical registry to evaluate patient outcomes. In this study we evaluated the feasibility of implementing the GLA:D® Back program in Australia. We considered clinician and patient recruitment and retention, program fidelity, exploring clinicians’ and patients’ experiences with the program, and participant outcome data collection.

Methods
Clinicians (chiropractors and physiotherapists) were recruited and participated in a 2-day GLA:D® Back training course. Patients were eligible to participate if they had persistent or recurrent LBP. Feasibility domains included the ability to: (1) recruit clinicians to undergo training; (2) recruit and retain patients in the program; (3) observe program fidelity; and (4) perceive barriers and facilitators for GLA:D® Back implementation. We also collected data related to: (5) clinician confidence, attitudes, and behaviour; and (6) patient self-reported outcomes related to pain, disability, and performance tests.

Results
Twenty clinicians (8 chiropractors, 12 physiotherapists) participated in the training, with 55% (11/20) offering GLA:D® Back to their patients. Fifty-seven patients were enrolled in the program, with 67% (38/57) attending the final follow-up assessment. Loss to follow up was mainly due to the effects of the COVID-19 pandemic. We observed program fidelity, with clinicians generally delivering the program as intended. Interviews revealed two clinician themes related to: (i) intervention acceptability; and (ii) barriers and facilitators to implementation. Patient interviews revealed themes related to: (i) intervention acceptability; and (ii) program efficacy. At 3 months follow-up, clinicians demonstrated high treatment confidence and biomedical orientation. Patient outcomes trended towards improvement.

Conclusion
GLA:D® Back implementation in Australia appears feasible based on clinician recruitment, program acceptability and potential benefits for patient outcomes from the small sample of participating clinicians and patients. However, COVID-19 impacted patient recruitment, retention, and data collection. To scale-up GLA:D® Back in private and public settings, further work is warranted to address associated barriers, and to leverage facilitators.
Are there differences in arthroscopic and histological features between traumatic and degenerative rotator cuff tears in elderly patients? A prospective dual-center analysis
Authors: Shibata Terufumi , Izaki Teruaki , Nishio Jun , Miyake Satoshi , Arashiro Yasuhara , Minamikawa Tomohiko , Minokawa So , Shibata Yozo , Yamamoto Takuaki 
Published: April 2022

AbstractBackgroundDiscriminating traumatic rotator cuff tears (RCTs) from degenerative RCTs is sometimes difficult in elderly patients because the prevalence of asymptomatic RCTs increases with age. Little intraoperative information is available on the characteristics of traumatic and degenerative RCTs in elderly patients. The purpose of this study was to compare the arthroscopic findings and histological changes of the coracoacromial ligament (CAL) between traumatic and degenerative RCTs in elderly patients.MethodsForty-two shoulders of 42 patients aged ≥ 65 years underwent arthroscopic rotator cuff repair. Nineteen patients had traumatic full-thickness RCTs (Group T), and 23 had degenerative full-thickness RCTs (Group D). The quality of the rotator cuff tissue and the condition of the long head of the biceps were examined. The grade of CAL was evaluated both arthroscopically and histologically. The stiffness of the musculotendinous unit was calculated by measuring the force and displacement using a tensiometer. The arthroscopic and histological findings of the two groups were compared.ResultsAlthough the mean tendon displacement was comparable, the stiffness was different between Group T and Group D (0.56 ± 0.31 and 1.09 ± 0.67 N/mm, respectively;p < 0.001). Both arthroscopic and histological analysis of the CAL showed that the degenerative changes in the CAL were milder in Group T than in Group D (p < 0.001 andp < 0.001, respectively). There was a moderate positive correlation between the arthroscopic findings of CAL degeneration and the histopathological changes in this ligament (r = 0.47,p = 0.002).ConclusionsTraumatic RCTs were characterized by preserved elasticity of the musculotendinous unit and milder CAL degeneration compared with degenerative RCTs even in elderly patients.
HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy
Authors: Hussain Khiyam , Liu Rena , Smith Rosanna C. G. , Müller Kri T. J. , Ghorbani Mohammadmersad , Macari Sofia , Cleary Kirstie L. S. , Oldham Robert J. , Foxall Russell B. , James Sonya , Booth Steven G. , Murray Tom , Dahal Lekh N. , Hargreaves Chantal E. , Kemp Robert S. , Longley Jemma , Douglas James , Markham Hannah , Chee Serena J. , Stopforth Richard J. , Roghanian Ali , Carter Matthew J. , Ottensmeier Christian H. , Frendéus Bjorn , Cutress Ramsey I. , French Ruth R. , Glennie Martin J. , Strefford Jonathan C. , Thirdborough Stephen M. , Beers Stephen A. , Cragg Mark S. 
Published: April 2022

Abstract
Background
Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophages (TAMs) provide potent pro-tumoral support. However, TAMs can also be harnessed to destroy tumor cells by monoclonal antibody (mAb) immunotherapy, through antibody dependent cellular phagocytosis (ADCP). This is mediated via antibody-binding activating Fc gamma receptors (FcγR) and impaired by the single inhibitory FcγR, FcγRIIb.

Methods
We applied a multi-OMIC approach coupled with in vitro functional assays and murine tumor models to assess the effects of hypoxia inducible factor (HIF) activation on mAb mediated depletion of human and murine cancer cells. For mechanistic assessments, siRNA-mediated gene silencing, Western blotting and chromatin immune precipitation were utilized to assess the impact of identified regulators on FCGR2B gene transcription.

Results
We report that TAMs are FcγRIIbbright relative to healthy tissue counterparts and under hypoxic conditions, mononuclear phagocytes markedly upregulate FcγRIIb. This enhanced FcγRIIb expression is transcriptionally driven through HIFs and Activator protein 1 (AP-1). Importantly, this phenotype reduces the ability of macrophages to eliminate anti-CD20 monoclonal antibody (mAb) opsonized human chronic lymphocytic leukemia cells in vitro and EL4 lymphoma cells in vivo in human FcγRIIb+/+ transgenic mice. Furthermore, post-HIF activation, mAb mediated blockade of FcγRIIb can partially restore phagocytic function in human monocytes.

Conclusion
Our findings provide a detailed molecular and cellular basis for hypoxia driven resistance to antitumor mAb immunotherapy, unveiling a hitherto unexplored aspect of the TME. These findings provide a mechanistic rationale for the modulation of FcγRIIb expression or its blockade as a promising strategy to enhance approved and novel mAb immunotherapies.
Iterative 2D sparse signal reconstruction with masked residual updates for automotive radar interference mitigation
Authors: Chen Shengyi , Stockel Philipp , Taghia Jalal , Kühnau Uwe , Martin Rainer 
Published: April 2022

AbstractCompressive sensing has attracted considerable attention in automotive radar interference mitigation. However, these algorithms usually cannot be applied directly to commercial automotive radar as most of them are computationally intense. In this paper, we therefore introduce a computationally efficient two-dimensional masked residual updates (2D MRU) compressive sensing framework. By utilizing the sparsity of the beat signal in the frequency domain, the range-Doppler (RD) spectrum can be reconstructed with the help of undistorted samples in the beat signal. Unlike the other schemes, where a 2D signal measurement is vectorized into a 1D signal, the proposed 2D MRU can directly take a 2D signal measurement and reconstruct the corresponding RD spectrum. Furthermore, the 2D MRU framework can be easily integrated into well-known optimization schemes such as basis pursuit, iterative hard thresholding, iterative soft thresholding, orthogonal matching pursuit, and approximate message-passing algorithm. In addition to the standard iterative thresholding algorithms, we propose a novel prior-model-based iterative thresholding method to further reduce the computation time and reconstruction error. Theoretical analysis shows that the proposed framework can successfully reconstruct the RD spectrum with high probability. Moreover, numerical experiments demonstrate the superiority of the proposed framework in terms of computational complexity.
On the behaviour of solutions to a kind of third order neutral stochastic differential equation with delay
Authors: Mahmoud Ayman M. , Ademola Adeleke T. 
Published: April 2022

AbstractThis article demonstrates the behaviour of solutions to a kind of nonlinear third order neutral stochastic differential equations. Setting $x^{\prime }(t)=y(t)$

x
′

(
t
)
=
y
(
t
)
, $y^{\prime }(t) =z(t)$

y
′

(
t
)
=
z
(
t
)
the third order differential equation is ablated to a system of first order differential equations together with its equivalent quadratic function to derive a suitable downright Lyapunov functional. This functional is utilised to obtain criteria which guarantee stochastic stability of the trivial solution and stochastic boundedness of the nontrivial solutions of the discussed equations. Furthermore, special cases are provided to verify the effectiveness and reliability of our hypotheses. The results of this paper complement the existing decisions on system of nonlinear neutral stochastic differential equations with delay and extend many results on third order neutral and stochastic differential equations with and without delay in the literature.
Improving the quality of long-term care services in workforce dimension: expert views from Australia and South Korea
Authors: Lee Hyo Young , Short Stephanie , Lee Mi-Joung , Jeon Yun-Hee , Park Eunok , Chin Young-Ran 
Published: April 2022

Abstract
Background
The long-term care workforce is an essential factor in the provision of qualified long-term care services. Identifying workforce issues can help developing countries in East Asia and the Pacific prepare for the increase in the older population. Their experiences can be used as lessons for other countries. This study aimed to identify the workforce issues that should be addressed in order to provide high-quality long-term care services for older adults.

Methods
In-depth interviews and content analysis were conducted with a purposive sample of long-term care experts. There were eight participants from Australia and 14 from South Korea. The participants were questioned on important workforce issues to improve the quality of long-term care services. These were open-ended questions that comprised ideas derived from the literature. Major themes were systematically and comprehensively classified and coded to examine recurring comments and themes.

Results
The issues in the two countries were very similar: labor shortages, inadequate working conditions, insufficient career and staff training, and the need of counselors or consultants for finding proper services. There were also differences in terms of competency of the service operators and their corresponding multicultural competency.

Conclusions
Providing high-quality long-term care service requires multipronged approaches to workforce capacity and work environment. An adequate and competent workforce should be established to match the service needs of the older population. To improve quality, better working conditions and improved motivation to work in care for older people should be considered. Concurrently, each country would need a workforce strategy tailored to different conditions and environments. This should include policies to induce an influx into the workforce.
Prevalence and correlates of infertility related psychological stress in women with infertility: a cross-sectional hospital based survey
Authors: Teklemicheal Ashebir Getachew , Kassa Eyasu Mesfin , Weldetensaye Eskinder Kebede 
Published: April 2022

Abstract
Background
Psychological stress is commonly found among infertile women. Untreated stress can affect negatively the success of infertility treatment. Most of the available knowledge is generated from developed countries and is largely based on women undergoing In vitro fertilization (IVF) treatment. However, very little is known on infertile women from Ethiopia including other countries in East Africa. The aim of this study was to determine the prevalence of psychological stress and possible demographic-clinical correlates in Ethiopian women suffering from infertility.

Method
This cross sectional descriptive correlation study was conducted from May to August, 2021 involving 96 women undergoing a non-IVF treatment for infertility at Gandhi Memorial and Tikur Anbessa hospitals. The sampling was continuous and based on inclusion criteria that include infertility duration of a minimum one year, female sex and Ethiopian nationality. Data on Infertility related stress was collected using the Copenhagen Multi‐Centre Psychosocial Infertility-Fertility Problem Stress questionner administered by an interviewer. The socio demographic and clinical factors were collected using Amharic version of structured interviewer administered questionnaire and chart review. The analysis of relationship between infertility related stress and background variables was done with an independent sample t-test or one-way ANOVA statistics supplemented with effect size assessment.

Results
The prevalence of infertility related stress was overall 92.71% (95% CI, 87–98%). The personal, marital, and social subdomain mean scores (SD) were 2.74 (.80), 1.54 (.81) and 1.90 (.80), respectively. Infertility related stress was higher for those women who were: aged above 35, living in a cohabitation marital type, has no living children, and with 4–6 years duration of infertility (all P < 0.05). Whereas, there was insufficient evidence to suggest that infertility related stress varies by education, income, knowledge of cause of infertility or history of past treatment (all P > 0.05).

Conclusions
The prevalence of psychological stress among Ethiopia women having infertility was very high. The results provide preliminary evidence that infertility related stress is associated with age, marital status, motherhood status and duration of infertility. Responsible bodies need to avail psychological screening and services prioritizing women at higher risk of developing stress.
The role of ncRNAs in neuroblastoma: mechanisms, biomarkers and therapeutic targets
Authors: Huang Shaohui , Gong Naying , Li Jiangbin , Hong Mingye , Li Li , Zhang Ling , Zhang Hua 
Published: April 2022

AbstractNeuroblastoma (NB) is a malignant tumor in young children that originates from the neural crest of the sympathetic nervous system. Generally, NB occurs in the adrenal glands, but it can also affect the nerve tissues of the neck, chest, abdomen, and pelvis. Understanding the pathophysiology of NB and developing novel therapeutic approaches are critical. Noncoding RNAs (ncRNAs) are associated with crucial aspects of pathology, metastasis and drug resistance in NB. Here, we summarized the pretranscriptional, transcriptional and posttranscriptional regulatory mechanisms of ncRNAs involved in NB, especially focusing on regulatory pathways. Furthermore, ncRNAs with the potential to serve as biomarkers for risk stratification, drug resistance and therapeutic targets are also discussed, highlighting the clinical application of ncRNAs in NB.
Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data
Authors: Wang Wei , Yang Yu-Jie , Zhang Ri-Hong , Deng Jing-Yu , Sun Zhe , Seeruttun Sharvesh Raj , Wang Zhen-Ning , Xu Hui-Mian , Liang Han , Zhou Zhi-Wei 
Published: April 2022

Abstract
Background
Currently, there is no formal consensus regarding a standard classification for gastric cancer (GC) patients with < 16 retrieved lymph nodes (rLNs). Here, this study aimed to validate a practical lymph node (LN) staging strategy to homogenize the nodal classification of GC cohorts comprising of both < 16 (Limited set) and ≥ 16 (Adequate set) rLNs.

Methods
All patients in this study underwent R0 gastrectomy. The overall survival (OS) difference between the Limited and Adequate set from a large Chinese multicenter dataset was analyzed. Using the 8th American Joint Committee on Cancer (AJCC) pathological nodal classification (pN) for GC as base, a modified nodal classification (N’) resembling similar analogy as the 8th AJCC pN classification was developed. The performance of the proposed and 8th AJCC GC subgroups was compared and validated using the Surveillance, Epidemiology, and End Results (SEER) dataset comprising of 10,208 multi-ethnic GC cases.

Results
Significant difference in OS between the Limited and Adequate set (corresponding N0–N3a) using the 8th AJCC system was observed but the OS of N0limited vs. N1adequate, N1limited vs. N2adequate, N2limited vs. N3aadequate, and N3alimited vs. N3badequate subgroups was almost similar in the Chinese dataset. Therefore, we formulated an N’ classification whereby only the nodal subgroups of the Limited set, except for pT1N0M0 cases as they underwent less extensive surgeries (D1 or D1 + gastrectomy), were re-classified to one higher nodal subgroup, while those of the Adequate set remained unchanged (N’0 = N0adequate + pT1N0M0limited, N’1 = N1adequate + N0limited (excluding pT1N0M0limited), N’2 = N2adequate + N1limited, N’3a = N3aadequate + N2limited, and N’3b = N3badequate + N3alimited). This N’ classification demonstrated less heterogeneity in OS between the Limited and Adequate subgroups. Further analyses demonstrated superior statistical performance of the pTN’M system over the 8th AJCC edition and was successfully validated using the SEER dataset.

Conclusion
The proposed nodal staging strategy was successfully validated in large multi-ethnic GC datasets and represents a practical approach for homogenizing the classification of GC cohorts comprising of patients with < 16 and ≥ 16 rLNs.
Do I want more if you help me? The impact of grandparental involvement on men’s and women’s fertility intentions
Authors: Rutigliano Roberta , Lozano Mariona 
Published: April 2022

AbstractGrandparental support is positively associated with women’s labor force participation and fertility transitions. Specifically, grandparental support shapes adult child’s entry into parenthood by influencing adult child’s expectations about future care. In this framework, the current study investigates whether observed grandparental support impacts adult sons’ and adult daughters’ fertility intentions in a lowest-low fertility country such as Spain. We use data from the new wave of the Spanish Fertility Survey (2018), and we find that receiving grandparental support has a positive and significant impact on women’s but not on men’s fertility intentions. Furthermore, this impact remains positive after controlling for women’s socio-economic characteristics. Finally, education results the main mediator for the relationship between grandparental support and women’s fertility intentions, with highly educated women displaying a significantly increase of their fertility intentions compared to their low-educated counterparts. Our findings highlight gender differences in the perceived role of grandparental support for future fertility, and the importance of informal care for balancing family and work in the Spanish context.
Female employment and first childbirth in Italy: what news?
Authors: Alderotti Giammarco 
Published: April 2022

AbstractIn the last decades, female participation in the labour market has been found to be increasingly associated with higher fertility levels in high-income countries—albeit to a lesser extent in countries characterised by poor welfare support to working mothers. Among the latter camp, Italy is an intriguing case study, which is marked by lower female labour force participation and fertility rates when compared to most other European countries. Recent macro-level evidence suggests that a reverse in the female employment/fertility relationship is gradually taking place in Italy, driven largely by the Northern regions. However, the evolution of the relationship between female employment and fertility has (to the best of my knowledge) never been addressed at the micro-level. Through the use of individual-level retrospective data, this study analyses the link between female employment and fertility, paying special attention to differences between Northern and Southern Italy, and its evolution over time. The results suggest that female employment began to be positively associated to fertility at the individual level, both in Northern and Southern Italy (although to slightly different extents), from 2010 onwards.