bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIFITAS LKPD BERBASIS INKUIRI TERBIMBING PADA MATERI GARIS SINGGUNG LINGKARAN KELAS VIII
Authors: Sari Intan Permata , Maulidiya Della , Susanta Agus 
Published: November 2022

This research was done to produce student worksheet (LKPD) based on inquiry on tangent line to a cirle for grade 8 that is effective. This research was a Research and Development by modifying 4-D thiagarajan method into 3 phases of it, which are define, design, and develop. The effectiveness of LKPD was done to 32 students of Class VIII A in SMP Negeri 11, Bengkulu city as an effective class and was observed by two observers. Instrument of this research was effective sheet consist of teacher activity observation sheet, sudent activity observation sheet and student’s response sheet. The result of this research showed that LKPD was in effective category based on : 1) teacher activity observation that consisted of 8 statements was in very good category with an average score 34,5; 2) student activity observation that consisted of 7 statements was in very good category with an average score 30,17; 3) student’s response that consist of 10 statements was in very good category with an average score 43,76; and 4) learning outcome of students based on score of LKPD and Final Test (THB) was in good category with classical mastery persentage up to 93,75%.
ANALISIS FAKTOR INTERNAL DAN EKSTERNAL DALAM MENINGKATKAN KEPUASAN PELANGGAN PT. TOYOTA HADJI KALLA TOYOTA KENDARI PADA MASA PANDEMI COVID-19
Authors: Sarita Kiki Fatimah , Akib Mulyati , Husin Husin , Ahmad Ahmad , Armawadin Muhammad , Mirosea Nitri 
Published: November 2022

Penelitian ini bertujuan untuk mengidentifikasi menganalisis faktor internal dan faktor eksternal dari PT. Hadji Kalla Toyota Kendari dalam meningkatkan kepuasan pelanggan selama masa Pandemi Covid-19. Jenis penelitian ini adalah penelitian deskriptif yang dimaksudkan untuk mendapatkan mendapatkan gambaran dan keterangan-keterangan terkait strategi pengembangan usaha dalam meningkatkan kepuasan pelanggan pada masa Pandemi Covid-19 pada PT. Hadji Kalla Toyota Kendari. Jenis data dalam penelitian ini adalah data primer dan data sekunder. Alat analisis penelitian ini adalah analisis Stength, Weakness, Opportunities, dan Threats (SWOT). Hasil penelitian menemukan bahwa Faktor Internal pada PT. Hadji Kalla Toyota Kendari terdiri dari a)Kekuatan yang mencakup aspek tempat, jasa pelayanan dan fasilitas, kualitas pelayanan jasa dan kualitas SDM yang handal dan b)Kelemahan, yang mencakup harga jasa pelayanan yang mahal dan waktu penyelesaian servisi yang panjang, sementara faktor Eksternal PT. Hadji Kalla Toyota Kendari terdiri dari a)Peluang, yang mencakup pangsa pasar yang terbuka lebar, promosi dan diskon menarik, dan dukungan pemerintah, dan b)Tantangan, yang mencakup Dampak Pandemi Covid-19 terhadap industri otomotif, dan tantangan dari competitor lain.Kata Kunci : Analisis SWOT, Identifikasi faktor, Sektor Otomotif
PENGARUH PENANAMAN MODAL DALAM NEGERI DAN PENANAMAN MODAL ASING TERHADAP PENYERAPAN TENAGA KERJA SEKTORAL DI PROVINSI SULAWESI TENGGARA
Authors: Rachman Arief , Muthalib Abd. Azis , Rosnawintang Rosnawintang , Harafah LM 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis: (1).Pengaruh investasi Penanaman Modal Dalam Negeri) terhadap penyerapan tenaga kerja sektoral di Provinsi Sulawesi Tenggara. (2) Pengaruh investasi Penanaman Modal Asing terhadap penyerapan tenaga kerja sektoral di Provinsi Sulawesi Tenggara. Metode penelitian yang digunakan adalah penelitian kuantitatif. Pengumpulan data menggunakan teknik studi dokumen. Teknik analisis data yang digunakan analisis deskriptif statistik, dan analisis regresi berganda data panel. Hasil penelitian menyimpulkan bahwa: (1) Penanaman Modal Dalam Negeri (PMDN) berpengaruh signifikan dan positif terhadap penyerapan tenaga kerja sektoral di Provinsi Sulawesi Tenggara. Artinya peningkatan investasi dalam negeri dapat meningkatkan penyerapan tenaga kerja sektoral di Provinsi Sulawesi Tenggara. (2) Penanaman Modal Asing (PMA) berpengaruh signifikan dan positif terhadap penyerapan tenaga kerja sektoral di Provinsi Sulawesi Tenggara. Artinya peningkatan investasi dari luar negeri dapat meningkatkan penyerapan tenaga kerja sektoral di Provinsi Sulawesi Tenggara namun peningkatannya relatif kecil. Kata Kunci: Penanaman Modal Dalam Negeri, Penanaman Modal Asing, Penyerapan Tenaga Kerja Sektoral
PENGARUH JUMLAH PENDUDUK, PENDIDIKAN DAN KEMISKINAN TERHADAP KETIMPANGAN PENDAPATAN DI KABUPATEN/KOTA PROVINSI SULAWESI TENGGARA
Authors: Arfian Arfian , Harafah La Ode Muhammad , Balaka Muhammah Yani , Aedy Hasan , Saranani Fajar , Rumbia Wali Aya 
Published: November 2022

Tujuan Penelitian ini untuk menganalisis pengaruh jumlah penduduk, Pendidikan dan kemiskinan terhadap ketimpangan pendapatan di Kabupaten/Kota Provinsi Sulawesi Tenggara yang berjumlah 14 Kabupaten/Kota. Sedangkan periode penelitian selama 5 tahun (2016-2020). Jenis penelitian ini adalah verifikatif dengan pendekatan kuantitatif dalam model regresi data panel. Hasil penelitian menunjukkan bahwa jumlah penduduk tidak berpengaruh signifikan terhadap ketimpangan pendapatan. pendidikan mempunyai pengaruh yang signifikan terhadap ketimpangan pendapatan. Kemiskinan berpengaruh signifikan terhadap Ketimpangan pendapatan Secara simultan jumlah penduduk, pendidikan dan kemiskinan berpengaruh signifikan terhadap ketimpangan pendapatan. Kata Kunci: Ketimpangan, data panel
ANALISIS INTERAKSI SPASIAL KETENAGAKERJAAN ANTAR KABUPATEN/KOTA DI PROVINSI SULAWESI TENGGARA
Authors: Marhum Marhum , Syarif Muhammad , Boni Yohanes , Saenong Zainudin , Rostin Rostin 
Published: November 2022

Studi ini bertujuan untuk mengetahui dan menganalisis interaksi spasial pertumbuhan ekonomi dan ketenagakerjaan antar Kabupaten/Kota di Provinsi Sulawesi Tenggara, dan untuk mengetahui dan menganalisis faktor-faktor yang dapat mempengaruhi interaksi spasial pertumbuhan ekonomi dan ketenagakerjaan antar Kabupaten/Kota di Provinsi Sulawesi Tenggara. Jenis data yang digunakan adalah data sekunder. Analisis data yang digunakan adalah Indeks Moran’s dan Skalogram. Hasil penelitian menunjukan bahwa (1) Kabupaten/kota di Provinsi Sulawesi Tengggara dan sekitarnya terindikasi adanya keterkaitan dalam perkembangan ketenagakerjaan, Artinya suatu wilayah Kabupaten/Kota tidak berdiri sendiri dalam menyerap tenagakerja, tetapi dipengaruhi oleh tenagakerja yang ada di wilayah sekitarnya. (2) Kelengkapan fasilitas yang dimiliki oleh setiap wilayah Kabupaten/Kota belum sepenuhnya mampu berpengaruh terhadap interaksi spasial pertumbuhan ekonomi antar Kabupaten/Kota di Provinsi Sulawesi Tenggara. Sedangkan kelengkapan fasilitas yang dimiliki setiap wilayah Kabupaten/Kota sudah berpengaruh terhadap interaksi spasial ketenagakerjaan antar Kabupaten/Kota di Provinsi Sulawesi Tenggara. Kata Kunci: Interaksi Spasial, Ketenagakerjaan, Indeks Morans
FAKTOR FAKTOR EFEKTIFITAS SISTEM PEMBAYARAN PAJAK MELALUI SISTEM E-BILLING PADA DINAS SUMBER DAYA AIR DAN BINA MARGA PROVINSI SULAWESI TENGGARA
Authors: Syamsi Nur , Arifuddin Arifuddin , Saranani Fajar , Dali Nasrullah , Gamsir Gamsir 
Published: November 2022

Penelitian ini untuk menganalisis tingkat efektifitas e-billing sistem dan faktor-faktor yang memperkuat atau melemahkan peran sisitem pembayaran pajak. Jenis data dalam penelitian ini adalah data primer dan data sekunder yang diperoleh dari Dinas Sumber Daya Air dan Bina Marga Provinsi Sulawesi Tenggara yaitu data belanja modal tahun 2016-2020.Analisis yang digunakan statistic deskriptif dan teknik word cloud.Hasil penelitian menunjukan bahwa karakter kemudahan proses layanan 54% dan karakter kemudahan akses 77% berpengaruh sangat efektif sedangkan adalah karakteristik operasional sistem 57%,karakteristik proses yang cepat 47%, dan karakteristik kemutakhiran sistem 58% berpengaruh cukup efektif.Adanya unsur keamanan, akurat, canggih, proses cepat, dan efektif dalam pemanfaatan sistem e-billing menjadi faktor-faktor dominan yang mendukung penguatan peran sisitem e-billing. Sedangkan aspek tanpa rekaman riwayat transaksi, operasional yang rumit, rentan terinveksi virus, keamanan jaringan, dan sering error menjadi faktor-faktor dominan yang melemahkan peran sistem e-billing dalam meningkatkan minat wajib pajak dalam bertransaksi. Kata Kunci: Sistem e-billing, Efektivitas Kepatuhan, Efektivitas Transaksi
Social impact of green roofs
Authors: Nguyen Dang Hoai-Anh , Legg Rupert , Khan Aila , Wilkinson Sara , Ibbett Nicole , Doan Anh-Tuan 
Published: November 2022

Green roofs are recognised as contributing towards building-related energy efficiency. Since roofs account for 20–25% of all urban surface areas, it is not surprising that such a green system can offer a sustainable solution to decreased energy consumption. The current literature on green roofs mostly focuses on the eco-benefits of such structures. A handful of research papers1 have theorised that as green roofs become more prevalent, there will be associated social outcomes for an urban community. However, empirical work in this space is minimal. This research addresses this gap and contributes to the literature by providing insights into city dwellers’ social experiences when using a green roof space. This study identified a green roof space in central Sydney, Australia: the Alumni Green at the University of Technology Sydney. The roof, containing a garden, a concrete open space and a raised grass area amounting to 1,200 m2, is above parts of the university’s library and classrooms, and is easily accessible by staff, students, and members of the public. Two members of the research team conducted surveys on site. Some green-roof users were also contacted via email. Over 128 individuals began the survey, although after removing responses that were incomplete or containing errors, 104 responses remained. The findings revealed that users, most commonly, relaxed or socialised on the green roof, with exercise a far less frequent activity. Further, those who frequented the green roof once a week or more reported significantly greater social well-being and attachment to place than those who visited less. Likewise, those who visited the green roof for periods of 30 min or more also reported greater social wellbeing. There were no significant differences between frequency and length of use and users’ perspectives on the green roof’s economic, physical, collective identity or environmental impacts. These present findings have implications for urban and landscape designers, as they reveal that green roofs have similar social and place-attachment benefits to those observed of green spaces in the literature. Given that green roofs can fit in places that parks or other open spaces often cannot, their implementation should be encouraged to promote social well-being and place attachment.
Genome-wide association analysis reveals 6 copy number variations associated with the number of cervical vertebrae in Pekin ducks
Authors: Xu Yaxi , Hu Jian , Fan Wenlei , Liu Hehe , Zhang Yunsheng , Guo Zhanbao , Huang Wei , Liu Xiaolin , Hou Shuisheng 
Published: November 2022

As a critical developmental stage in vertebrates, the vertebral column formation process is under strict control; however, we observed variations in the number of cervical vertebrae in duck populations in our previous study. Here, we further explored the variations in the number of vertebrae in two duck populations: 421 Pekin duck × mallard F2 ducks and 850 Pekin ducks. Using resequencing data of 125 Pekin ducks with different numbers of cervical vertebrae and 352 Pekin duck × mallard F2 ducks with different numbers of thoracic vertebrae, we detected whole-genome copy number variations (CNVs) and implemented a genome-wide association study (GWAS) to identify the genetic variants related to the traits. The findings verified the existence of variations in the number of cervical vertebrae in duck populations. The number of cervical vertebrae in most ducks was 15, while that in a small number of the ducks was 14 or 16. The number of cervical vertebrae had a positive influence on the neck production, and one cervical vertebra addition could increase 11 g or 2 cm of duck neck. Genome-wide CNV association analysis identified six CNVs associated with the number of cervical vertebrae, and the associated CNV regions covered 15 genes which included WNT10A and WNT6. These findings improve our understanding of the variations in the number of vertebrae in ducks and lay a foundation for future duck breeding.
KI effects on corrosion inhibition for 1018 steel in acid media using Medicago sativa
Authors: Rodríguez-Torres A. , Valladares-Cisneros M. G. , Saldaña Heredia A. , González-Rodríguez J. G. 
Published: November 2022

Medicago sativa (M. sativa)extract is a safe and eco-friendly corrosion inhibitor of 1018 steel in acid media. The inhibitor reached a maximum efficiency of 85% by using 500 ppm. In this work, we study the use of KI as an add-on to increase the inhibition efficiency ofM. sativa, as well as making the natural inhibitor competitive with the commercial ones. We evaluated the effect of halide ions through the variation of different concentrations of KI and its synergy with the extract ofM. sativaas a corrosion inhibitor of carbon steel in 0.5 M sulfuric acid and at different temperatures. The results were obtained through electrochemical techniques such as electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP) curves, and weight loss gravimetric technique. It was found that halide ions increase the inhibition efficiency ofM. sativafrom 85 to 95% when 5 mM concentration of KI was used. The efficiency of the inhibition increases proportionally with the immersion time but reduces when the temperature increases. The addition of iodide ions (I−) revealed that it exerts a synergistic effect on the inhibition of corrosion with the extract ofM. sativa. However, when studying the metal surface using a scanning electron microscope, pitting corrosion was found.
Dietary copper intake and risk of myocardial infarction in US adults: A propensity score-matched analysis
Authors: Wen He , Niu Xiaona , Hu Lang , Sun Nan , Zhao Ran , Wang Qiuhe , Li Yan 
Published: November 2022

ObjectivesMost studies have examined the association between serum copper and myocardial infarction, but there is little evidence of the association between dietary copper intake and myocardial infarction.Materials and methodsThe study included a total of 14,876 participants from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression model was used to analyze the association between dietary copper intake and the risk of myocardial infarction. To reduce selection bias, we use nearest neighbor propensity score matching (PSM) in a 1:2 ratio. Restricted cubic spline (RCS) method is used to study the non-linear relationship. Subgroup stratification was used to further investigate the association between copper intake and myocardial infarction.ResultsThe median dietary copper intake was 1.0825 mg/day. A myocardial infarction had occurred in approximately 4.4% (655) of the participants. Before and after matching, multivariate logistic regression models revealed a negative correlation between dietary copper intake and the risk of myocardial infarction. The higher quartile of subjects had a noticeably lower risk of myocardial infarction in comparison to those in the first quartile of copper intake. According to RCS findings, dietary copper intake and myocardial infarction have a non-linear and dose-response relationship. According to stratified analysis, the dietary copper intake was a substantial protective element for those who were ≥ 50 years old, female, 25 ≤BMI &lt;30, with history of smoking, hypertension, diabetes and ortholiposis.ConclusionIncreased dietary copper intake was associated with a lower risk of myocardial infarction. It is especially significant in elderly-aged women, overweight individuals, smokers, hypertension, and diabetic patients.
Development and validation of a predictive model of the impact of single nucleotide polymorphisms in the ICAM-1 gene on the risk of ischemic cardiomyopathy
Authors: Naman Tuersunjiang , Abuduhalike Refukaiti , Yakufu Mubalake , Bawudun Ayixigu , Sun Juan , Mahemuti Ailiman 
Published: November 2022

ObjectivePrevious research has linked single nucleotide polymorphisms (SNPs) in the ICAM-1 gene to an increased risk of developing ischemic cardiomyopathy (ICM); however, a diagnostic model of ICM according to the ICAM-1 variant has not yet been developed. Therefore, this study aimed to explore the correlation between SNPs in ICAM-1 and the presence of ICM, along with developing a diagnostic model for ICM based on the variants of the ICAM-1 gene.MethodThis study recruited a total of 252 patients with ICM and 280 healthy controls. In addition, all the participants were genotyped for SNPs in the ICAM-1 gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Using the training dataset of 371 people, we constructed a nomogram model based on ICAM-1 gene variants and clinical variables. To optimize the feature choice for the ICM risk model, a least absolute shrinkage and selection operator (LASSO) regression model was adopted. We also employed multivariable logistic regression analysis to build a prediction model by integrating the clinical characteristics chosen in the LASSO regression model. Following the receiver operating characteristic (ROC), a calibration plot and decision curve analysis (DCA) were used to evaluate the discrimination, calibration, and clinical usefulness of the predictive model.ResultThe predictors involved in the prediction nomogram included age, smoking, diabetes, low-density lipoprotein-cholesterol, hemoglobin, N-terminal pro-B-type natriuretic peptide, ejection fraction, and the rs5491 SNP. The nomogram model exhibited good discrimination ability, with the AUC value of ROC of 0.978 (95%CI: 0.967–0.989, P &lt; 0.001) in the training group and 0.983 (95% CI: 0.969–0.998, P &lt; 0.001) in the validation group. The Hosmer–Lemeshow test demonstrated good model calibration with consistency (Ptraining group = 0.937; Pvalidation group = 0.910). The DCA showed that the ICM nomogram was clinically beneficial, with the threshold probabilities ranging from 0.0 to 1.0.ConclusionThe AT genotype in rs5491 of the ICAM-1 gene was associated with having a higher frequency of ICM. Individuals carrying the mutant AT genotype showed a 5.816-fold higher frequency of ICM compared with those with the AA genotype. ICM patients with the AT genotype also had a higher rate of cardiogenic death. We, therefore, developed a nomogram model that could offer an individualized prediction of ICM risk factors.
Significant risk of COVID-19 and related-hospitalization among patients with adrenal insufficiency: A large multinational survey
Authors: Yedinak Christine , Ross Ian Louis 
Published: November 2022

ObjectiveTo determine self-reported incidence and potential risk factors for COVID-19 in patients with adrenal insufficiency (AI).MethodsA 27-item AI survey was developed for AI and COVID-19 status, vetted by specialists and patients, and distributed via social media, websites, and advocacy groups. Participation was voluntary and anonymous. Data were collected from September 20th, 2020 until December 31st, 2020.ResultsRespondents (n=1291) with self-reported glucocorticoid treatment for AI, completed the survey, with 456 who reported having symptoms and were screened for COVID-19 during 2020; 40 tested positive (+ve), representing an 8.8% incidence. Of the COVID-19+ve, 31 were female (78%), with mean age of 39.9 years. COVID-19 among AI patients occurred most commonly in those aged 40–59 years (n=17; 42.5%); mean time since AI diagnosis was 13.5 years (range 0.2−42.0 years). Pulmonary disease, congenital adrenal hyperplasia, and higher maintenance doses of glucocorticoids were significantly associated with +ve COVID-19 (p=0.04, p=0.01, and p=0.001, respectively. In respondents the cumulative incidence of COVID-19+ve during 2020 was 3.1%; greater than the 1.03% worldwide-incidence reported by WHO, by December 31st, 2020. There was a 3-fold (95% CI 2.16-3.98) greater relative risk (RR) of COVID-19 infection and a 23.8- fold (95% CI 20.7-31.2) RR of hospitalization in patients with AI, compared with the global population.ConclusionA markedly raised RR of COVID-19 and hospitalization in respondents reporting chronic AI was detected. We found that a diagnosis of congenital adrenal hyperplasia, age&gt;40 years, male gender, pulmonary disease, and higher maintenance doses of glucocorticoids were associated with greatest risk.
Low expression of INMT is associated with poor prognosis but favorable immunotherapy response in lung adenocarcinoma
Authors: Zhou Xincheng , Zou Bing , Wang Jian , Wu Lihong , Tan Qiang , Ji Chunyu 
Published: November 2022

Background: The expression of INMT (indolethylamine N-methyltransferase) has been reported to be downregulated in non-small-cell lung cancer (NSCLC). However, the role of INMT in NSCLC remains elusive. We aim to investigate the underlying mechanisms and clinical value of INMT in NSCLC, especially in lung adenocarcinoma (LUAD).Methods: Gene expression cohorts from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed to assess the effect of INMT on NSCLC. Gene expression data from an immunotherapy cohort were used to investigate the association of INMT with immunotherapy in NSCLC.Results: INMT expression was significantly downregulated in NSCLC compared with adjacent normal tissues. Downregulated INMT was associated with poor overall survival in LUAD, but not in lung squamous carcinoma. Multivariate Cox regression analysis suggested that INMT was an independent prognostic marker in LUAD. INMT had a reference value in the diagnosis and prognostic estimation of LUAD. Gene set enrichment analysis showed that pathways of the cell cycle and DNA damage response were enriched in the INMT low-expression group. The top 10 hub genes upregulated in the INMT low-expression group mainly activated the cell cycle pathway. In addition, more frequently mutated TP53 genes, higher aneuploidy scores, a fraction of genomes altered, MANTIS scores, and tumor mutation burden were found in tumors with low expression of INMT. Furthermore, patients with low expression of INMT showed favorable clinical benefits to anti-PD-1 treatment with higher enrichment scores of immune-related signatures.Conclusion: The low expression of INMT was associated with poor prognosis but favorable immunotherapy response in LUAD. INMT may affect the progression of LUAD by regulating the cell cycle and may serve as a valuable independent prognostic biomarker in patients with LUAD.