bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Experimental Study of Chlorite Stability in Varied Subduction Zone Lithologies with Implications for Fluid Production, Melting, and Diapirism in Chlorite-Rich Mélange Rocks
Authors: Lakey Shayne , Hermann Jörg 
Published: March 2022

AbstractFour ultramafic bulk compositions comprising only natural minerals were used to constrain the stability field of chlorite in a variety of subducted, chlorite-rich rocks through an examination of key chlorite dehydration reactions relevant to the sub-arc. Seventy-four piston cylinder experiments were conducted at a range of pressures (1.0–5.0 GPa) and temperatures (500°C–1150°C).Bulk 1 represents a chlorite mélange (Mg# = 0.94) typically formed in the subduction channel. This composition was used to examine the terminal chlorite reactions to olivine, orthopyroxene, and spinel at low pressure and to olivine, garnet, and spinel at high pressure. Chlorite achieves a thermal maximum stability at 2.0 GPa, 850°C; at 3.0 GPa, 850°C; and at 5.0 GPa, 760°C. The terminal chlorite breakdown reaction rises at a much steeper Clapeyron slope than shown in previous studies. Bulk 2 contains additionally antigorite and tremolite, to constrain phase relations in more fertile compositions. Chlorite reacts with clinopyroxene at ~100°C lower temperatures and with orthopyroxene at ~20°C–60°C lower temperatures than the terminal chlorite breakdown. The reactions have a subparallel Clapeyron slope and none of the three chlorite dehydration reactions crosses the antigorite breakdown reaction up to 5 GPa. This demonstrates that chlorite is the most stable carrier of H2O to high temperatures in subducted ultramafic rocks. Chlorite mélanges that form at the subduction plate interface will dehydrate at 850°C–800°C, 80–120 km depth for intermediate to hot subduction geotherms and liberate 10–12 wt.% of H2O, triggering wet melting in associated sediments. For cold subduction geotherms, chlorite dehydration occurs at 780°C–740°C, 120–170 km depth. Interaction of such fluids with sediments will likely produce a supercritical fluid phase. No melting in the ultramafic rocks has been observed at the chlorite breakdown reactions. Wet melting of the chlorite mélange at 3 GPa occurred between 1100°C and 1150°C.The stability of chlorite in more Fe-rich mélanges (bulk Mg# = 0.50 and 0.68, respectively) were conducted at 3.0 GPa and revealed thermal maxima at 650°C and 765°C, respectively. Collectively, the thermal stability of chlorite is dependent upon the Mg# of the bulk composition and spans over 200°C at sub-arc depths. The density of run products was calculated to test the validity of the chlorite mélange diapir model. With the progressive breakdown of chlorite, ultramafic chlorite mélanges transform into garnet peridotite, thereby losing any buoyancy they initially possessed. This makes the likelihood of mélange diapirs as a major transport mechanism through the sub-arc unfeasible.
Molecular and morphological analyses to improve taxonomic classification ofMetridia lucens/pacificain the North Pacific
Authors: Hirai Junya , Chen Fang , Itoh Hiroshi , Tadokoro Kazuaki , Lemay Matthew A , Hunt Brian P V , Tsuda Atsushi 
Published: March 2022

AbstractMolecular and morphological analyses were used to resolve the taxonomy of Metridia lucens/pacifica in the North Pacific. Phylogenetic analysis of mitochondrial cytochrome c oxidase subunit I (mtCOI) revealed two lineages of M. lucens and M. pacifica with an average sequence difference of 13.0%, which were supported by variations in nuclear internal transcribed spacer sequences. Metridia pseudopacifica in the eastern Pacific, mentioned by Mackas and Galbraith (2002), was included in M. lucens. The presence of M. lucens and M. pacifica was confirmed across the North Pacific, and different genetic population structures were suggested between the two species in the North Pacific based on mtCOI sequences. The morphological identification character of length of setae on the fifth pair of legs was not useful for classifying adult female M. pacifica and M. lucens. There were regional variations in prosome length and head angle; these two characters successfully classified &gt;98.2% of M. pacifica and M. lucens specimens from the North Pacific. As M. lucens and M. pacifica are key copepods in the North Pacific, accurate classification of individuals should be made in future studies to understand their relative contributions to marine ecosystems and improve detection of ecosystem change.
Total Knee Arthroplasty Assessments Should Include Strength and Performance-Based Functional Tests to Complement Range-of-Motion and Patient-Reported Outcome Measures
Authors: Capin Jacob J , Bade Michael J , Jennings Jason M , Snyder-Mackler Lynn , Stevens-Lapsley Jennifer E 
Published: March 2022

Abstract
Range of motion (ROM) and pain often define successful recovery after total knee arthroplasty (TKA), but these routine clinical outcomes correlate poorly or not at all to functional capacity after TKA. The purpose of this Perspective is to underscore the importance of muscle strength and performance-based functional tests in addition to knee ROM and patient-reported outcome (PRO) measures to evaluate outcomes after TKA. Specifically: (1) muscle strength is the rate-limiting step for recovery of function after TKA; (2) progressive rehabilitation targeting early quadriceps muscle strengthening improves outcomes and does not compromise ROM after TKA; (3) ROM and PROs fail to fully capture functional limitations after TKA; and (4) performance-based functional tests are critical to evaluate function objectively after TKA. This Perspective also addresses studies that question the need for or benefit of physical therapy after TKA because their conclusions focus only on ROM and PRO measures. Future research is needed to determine the optimal timing, delivery, intensity, and content of physical therapy.
The Investigatory Powers Act 2016 and Connected Vehicles: A New Form of Panspectric Veillance Looming?
Authors: Marson James , White Matthew , Ferris Katy 
Published: March 2022

Abstract
Connected and autonomous vehicles (CAVs) currently exist in varying states of readiness to, at one end of the spectrum, assist the driver in normal driving activities and at the other operate in fully autonomous mode, requiring no driver input at all. In facilitating these features, CAVs create, give access to, and allow communication of the data produced. The further along the autonomous scale CAVs progress, the greater the data generated, which are being harvested by original equipment manufacturers (OEMs), often unwittingly by the end user. The operation of the Investigatory Powers Act 2016 gives government agencies power to compel the retention and access to these data. Here we argue that the definitions within the Act result in CAV OEMs being subject to retention notices of the data generated by these vehicles. This issue, its extent and potential for abuse, and the lack of protection for those associated with the use of CAVs, hitherto unexamined in the legal academic literature, is the focus of this paper.
Higher R2* in the Red Nucleus Is Associated With Lead Exposure in an Asymptomatic Welder Cohort
Authors: Prado-Rico Janina Manzieri , Lee Eun-Young , Wang Ernest W , Yanosky Jeff D , Kong Lan , Chen Hairong , Navas-Acien Ana , Du Guangwei , Lewis Mechelle M , Mailman Richard B , Huang Xuemei 
Published: March 2022

Abstract
Lead is a nonessential metal and may be a coexposure in welding fumes. Preclinical data indicate lead may affect iron regulation. The current study investigated blood lead concentrations and their association with brain iron accumulation in workers with chronic welding fume exposure, with a focus on iron-rich subcortical regions of the cerebellum and basal ganglia. Occupational exposure, whole blood metal, and brain MRI data were obtained from 29 controls and 42 welders. R2* (1/T2*) and R1 (T1 relaxation rate) values were used to estimate brain iron and manganese content, respectively. Blood metals and brain R2* (in the red nucleus [RN], dentate nucleus, caudate, putamen, globus pallidus, and substantia nigra) were compared between groups. Associations between brain R2* values and exposure metrics were tested within each group, and analyses were adjusted for potential confounders. Welders had significantly higher levels of whole blood lead, manganese, iron, and copper. Welders also had higher R2* RN (p = .002), but not R1. A 2nd-order polynomial modeled the association between R2* RN and a long-term welding exposure metric. In welders, but not controls, R2* RN was associated positively with whole blood lead (r = 0.54, p = .003), and negatively with whole blood manganese (r = −0.43, p = .02). Higher blood Pb and lower blood Mn independently accounted for variance in high RN R2*. Together, these data suggest that higher RN R2* values may mark lead exposure in welders. Because lead is a known neurotoxicant, additional studies are warranted to confirm this finding, and ascertain its scientific and public/occupational health implications.
Closing the gap
Authors: Reising Virginia , Diegel-Vacek Lauren , Dadabo Lisa , Martinez Michelle , Moore Kelly , Corbridge Susan 
Published: March 2022

Abstract:
Social determinants of health have a significant impact on individual and community health outcomes. Using an integrated behavioral health model at a primary care clinic—a Federally Qualified Health Center—NPs led an interdisciplinary team to address outcome measures that are influenced by social determinants of health.
Five-Year Safety and Efficacy of Femtosecond Laser–Assisted Descemet Membrane Endothelial Keratoplasty
Authors: Sorkin Nir , Gouvea Larissa , Din Nizar , Mimouni Michael , Alshaker Sara , Weill Yishay , Gendler Shai , Slomovic Allan R. , Chan Clara C. , Rootman David S. 
Published: March 2022

Purpose:
The purpose of this study was to evaluate 5-year safety and efficacy outcomes of femtosecond-enabled Descemet membrane endothelial keratoplasty (F-DMEK) in patients with Fuchs' endothelial dystrophy (FED).

Methods:
This was a retrospective study, including patients with FED and cataract who underwent either F-DMEK (16 eyes of 15 patients) or manual DMEK (M-DMEK) (42 eyes of 37 patients) combined with cataract extraction. Outcome measures included visual acuity, graft detachment, graft survival, and endothelial cell loss.

Results:
The average follow-up in F-DMEK and M-DMEK was 57.1 ± 12.4 months and 58.5 ± 17.3 months, respectively (P = 0.757). The rates of primary failure (0% vs. 9.5%, P = 0.567), secondary failure (0% for both), and graft rejection (0% vs. 7.1%, P = 0.533) did not differ significantly between the groups. Improvement in best spectacle-corrected visual acuity was similar in F-DMEK and M-DMEK (0.32 ± 0.27 logarithm of the minimum angle of resolution and 0.35 ± 0.44 logarithm of the minimum angle of resolution, respectively, P = 0.165) and persisted at 2, 3, 4, and 5 years and at the last follow-up. The rates of graft detachment and rebubbling were significantly lower with 6.25% in F-DMEK and 33.3% in M-DMEK (P = 0.035). Cell-loss rates were lower in F-DMEK compared with M-DMEK throughout the follow-up, significantly so up to 2 years with a difference of 8.6% at 1 year (P = 0.023), 11.8% at 2 years (P = 0.021), 7.6% at 3 years (P = 0.088), 5.8% at 4 years (P = 0.256), 13.6% at 5 years (P = 0.169), and 7.1% at the final follow-up (P = 0.341).

Conclusions:
F-DMEK had an excellent safety and efficacy profile which was maintained over 5 years of follow-up. Lower endothelial cell-loss rates in F-DMEK compared with M-DMEK may help extend the duration of graft survival.
The Role of Age, Sex, Body Mass Index, and Sport Type on the Dynamic Exertion Test in Healthy Athletes: A Cross-Sectional Study
Authors: Sinnott Aaron M. , Eagle Shawn R. , Kochick Victoria , Preszler Jonathan , Collins Michael W. , Sparto Patrick J. , Flanagan Shawn D. , Elbin Robert J. , Connaboy Christopher , Kontos Anthony P. 
Published: March 2022

Background:
The dynamic exertion test (EXiT) was developed to help inform return to play after sport-related concussion, but some factors may threaten the internal validity of EXiT and affect clinical interpretation.

Objective:
To compare age, sex, BMI, and sport types across EXiT physiological [pre-EXiT and post-EXiT percentage of maximum heart rate (HR %max) and blood pressure (BP)], performance (change-of-direction task completion time and committed errors), and clinical [symptoms and rating of perceived exertion (RPE)] outcomes among healthy adolescents and adults.

Study design:
Cross-sectional.

Methods:
Eighty-seven participants (F = 55, 37.4%) reported symptoms and RPE during the EXiT, which consists of a 12-minute treadmill running protocol, and the dynamic circuit, ball toss, box shuffle (SHUF) and carioca (CAR), zig zag (ZZ), proagility (PA), and arrow agility (AA) tasks. Independent samples t tests were conducted for pre-EXiT and post-EXiT HR %max and BP and change-of-direction task completion time and Mann–Whitney U tests for errors, symptoms, and RPE. A series of 1-way analysis of variance (ANOVAs) and Kruskal–Wallis H tests were conducted to compare collision, contact, and noncontact sport types.

Results:
Adolescents had lower completion time across AA (P = 0.01) and male athletes lower than female athletes on CAR, ZZ, PA, and AA (P < 0.04). Male athletes reported greater RPE after the SHUF, CAR, and AA (P < 0.03). HR %max, errors, and symptoms were equivocal across all subgroups (P > 0.05).

Conclusion:
Age and sex should be considered in the interpretation of performance and clinical, but not physiological, EXiT outcomes. The EXiT is a standardized exercise assessment and generalizable to healthy athletes.
Extracorporeal Life Support Organization Guidelines for Fluid Overload, Acute Kidney Injury, and Electrolyte Management
Authors: Bridges Brian C. , Dhar Archana , Ramanathan Kollengode , Steflik Heidi J. , Schmidt Matthieu , Shekar Kiran 
Published: March 2022

Disclaimer:
This guideline for extracorporeal membrane oxygenation (ECMO) fluid and electrolyte management for all patient populations is intended for educational use to build the knowledge of physicians and other health professionals in assessing the conditions and managing the treatment of patients undergoing extracorporeal life support (ECLS)/ECMO and describe what are believed to be useful and safe practice for ECLS/ECMO, but these are not necessarily consensus recommendations. The aim of clinical guidelines is to help clinicians to make informed decisions about their patients. However, adherence to a guideline does not guarantee a successful outcome. Ultimately, healthcare professionals must make their own treatment decisions about care on a case-by-case basis, after consultation with their patients, using their clinical judgment, knowledge, and expertise. These guidelines do not take the place of physicians’ and other health professionals’ judgment in diagnosing and treatment of particular patients. These guidelines are not intended to and should not be interpreted as setting a standard of care or be deemed inclusive of all proper methods of care nor exclusive of other methods of care reasonably directed to obtaining the same results. The ultimate judgment must be made by the physician and other health professionals and the patient in light of all the circumstances presented by the individual patient, and the known variability and biologic behavior of the clinical condition. These guidelines reflect the data at the time the guidelines were prepared; the results of subsequent studies or other information may cause revisions to the recommendations in these guidelines to be prudent to reflect new data, but Extracorporeal Life Support Organization (ELSO) is under no obligation to provide updates. In no event will ELSO be liable for any decision made or action taken in reliance upon the information provided through these guidelines.
Body Image Issues in Patients With Colorectal Cancer
Authors: Phung Van Du , Fang Su-Ying 
Published: March 2022

Background
Stomas in colorectal cancer (CRC) survivors lead to body image problems. Advances in treatment help reduce the rate of stoma formation, but body image distress is still frequently experienced in CRC survivors.

Objectives
This review is aimed toward mapping and describing the state of knowledge regarding body image in patients with CRC.

Methods
A systematic literature search complying with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines was conducted. Screening and data extraction were performed by 2 reviewers independently for all potentially eligible studies.

Results
A total of 56 eligible articles were selected. The majority of these studies were quantitative studies (85%). The eligible studies were classified into 4 broad categories: instruments used to assess body image, prevalence of body image distress, factors related to body image, and impact of body image distress. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-CR38) colorectal questionnaire was the most common measurement tool found among the reviewed studies (70%), and body image distress was reported by 25.5% to 86% of participants. Excluding gender, age, type of surgery, adjuvant therapy, time from diagnosis, social support, and stoma status, changes in bowel habits was identified as affecting the body image of patients with CRC.

Conclusion
Changing bowel habits emerged as a significant factor causing body image distress for CRC survivors.

Implications for Practice
Clinicians should raise awareness about body image distress in patients with CRC, focus on finding effective measures and interventions intended to help alleviate symptoms of bowel dysfunction, and prepare patients to adapt to altered bowel functions.
An Intervention Framework for Addressing Stigma on College Campuses
Authors: Tomar Nikhil , Jensen Todd M. , Pace Nelson 
Published: March 2022

Abstract
The ongoing COVID-19 pandemic will only exacerbate the rising mental health concerns among college students. However, stigma toward such concerns continues to hinder mental health care utilization among the students, requiring urgent evidence that can help guide college campuses in implementing effective antistigma interventions. We propose and provide evidence for an intervention based on findings from a 3-year-long antistigma intervention that was implemented on a Southeastern college campus in the United States. Unique random samples of college students, totaling N = 1727 across 3 years, were recruited as participants. Each year, participants completed a preintervention and postintervention survey comprising of questions related to demographics, stigma, and mental health care knowledge. Findings indicate that the stakeholder-led intervention decreased personal stigma and increased mental health care knowledge among students who were exposed to the intervention. Further research is needed to assess feasibility and efficacy of the proposed intervention framework on other campuses.
Personal and Bystander Harassment Experiences and Outcomes for Hospital Nurses
Authors: Wadsworth Pamela , Estrada Armando X. 
Published: March 2022

OBJECTIVES
To examine experiences, context, and outcomes of personal and bystander harassment among hospital nurses.

BACKGROUND
Harassment of nurses is common, affecting victims and bystanders. Yet, little is known about the nature and context of these experiences.

METHOD
A cross-sectional study of hospital nurses was completed via an anonymous online survey.

RESULTS
A majority of nurses experienced personal or bystander harassment. Nearly half experienced both of these forms of harassment. Personal harassment victims frequently told their managers and coworkers, but actions to prevent further harassment or mitigate harm were rare. Bystanders frequently intervened to help victims of personal harassment but rarely reported it. These experiences negatively impacted work relationships and performance.

CONCLUSION
Personal and bystander harassment may co-occur in cultures that tolerate harassment. The lack of response to personal harassment and lack of reporting of bystander harassment may perpetuate it.
Clinical Evaluation of High-Resolution MRI Combined With DWI in Identifying Vulnerable Carotid Plaque
Authors: Wang Xinyi , Li Jing , Wang Xin , Gao Jialu , Jing Hongyan , Xing Ying 
Published: March 2022

Background:
High-resolution magnetic resonance imaging combined with diffusion weighted imaging is used to identify vulnerable plaques (VP) and their characteristic components, and apparent diffusion coefficient (ADC) correlation analysis with serum inflammatory markers to assess plaque vulnerability.

Methods:
In this study, 60 eligible patients were included, including 29 patients in VP group and 31 patients in non-VP group (N group). The average ADC value, serum inflammatory marker levels (high-sensitivity C-reactive protein, myeloperoxidase, and erythrocyte sedimentation rate) of the 2 groups were measured, and the characteristics of different plaque components and ADC levels of vascular wall in VP group were compared, to evaluate the correlation between serum inflammatory markers and the mean value of plaque ADC.

Results:
The results showed that the ADC mean value of the plaques in the VP group was significantly lower than that in the N group, and the levels of hypersensitive C-reactive protein and myeloperoxidase were correlated with the ADC mean value of the plaques.

Conclusion:
The ADC value of plaque measured by high-resolution magnetic resonance imaging combined with diffusion weighted imaging sequence can quantify the identification of VP and its characteristic components, reflect the inflammation of plaque to a certain extent, and thus prevent and treat stroke and other adverse outcomes more effectively.
What 736 Plastic Surgeons Think about Explantation and Capsulectomy: A Global Opinion Poll
Authors: Scheflan Michael , Gronovich Yoav , Maisel Lotan Adi , Winder Gilad 
Published: March 2022

Background:
Breast implant illness, although not classified as a disease entity, has recently gained significant attention globally. The purpose of this study was to assess the status of explantation practices, discuss plastic surgeon’s attitude toward requests for explantation and capsulectomy, and evaluate surgical management when accepting these challenges.

Methods:
Twenty closed-ended multiple choice questions were formulated to an opinion poll. The anonymous opinion poll was distributed to members of American Society for Aesthetic Plastic Surgery and presidents of plastic surgery societies on all continents.

Results:
A total of 736 plastic surgeons responded to the opinion poll. Although geographic variation was noted, a majority of 69.8 percent stated that explantation surgery had increased in their practice compared to the previous year. Requests for explantation without capsulectomy met with high acceptance rates among surgeons, regardless of whether patients were asymptomatic or not. Patients who also requested capsulectomy received less enthusiastic replies depending on the type of practice, years in practice, implant position, and type of capsulectomy (en bloc, total, or partial). When fat grafting was indicated, 68.7 percent stated that simultaneous lipofilling is limited when capsulectomy is performed, yet 44.5 percent stated that they would remove thin normal capsules in a symptomatic patient even when simultaneous fat grafting is requested by the patient.

Conclusion:
The opinion poll supports the hypothesis that demand for explantation and capsulectomy increased globally among symptomatic and asymptomatic patients; that attitudes toward simultaneous capsulectomy are divided; and that management may differ according to geographic location, experience, and type of practice.