bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the characteristics of blood lipid metabolism in twin pregnancy
Authors: Lou Yanqin , He Pei , Jiang Huijun , Xiang Li , Gao Xuemei 
Published: June 2022

Abstract
Objective:
This study aimed to investigate the characteristics of blood lipid metabolism in twin pregnancy and its combined with gestational diabetes mellitus (GDM) or pregnancy-induced hypertension (PIH).
Methods:
This study retrospectively analyzed 96 cases of twin pregnancy and 232 cases of full-term singleton pregnancy, and they were filed in our hospital, undergone antenatal examination and gave birth from March 2016 to March 2021. Among 96 cases of twin pregnancy, 22 cases had GDM, and 18 cases had gestational hypertension. Comparison of general data and blood lipid levels, including triglyceride (TG) and total cholesterol (TC), between twin pregnancy and singleton pregnancy was performed. Comparison of blood lipid levels between GDM group and non-GDM group in twin pregnancy was performed. Comparison of blood lipid levels between the PIH group and the non-PIH group in twin pregnancy was performed.
Results
For the twin pregnancy, the TG level in the third trimester was higher than that in the second and first trimester, and the TG level in the second trimester was higher than that in the first trimester (P < 0.05). For the twin pregnancy, the TC level in the second and third trimester was higher than that in the first trimester (P < 0.05), but there was no difference in the TC level between the second and third trimesters (P > 0.05). The TG level of twin pregnancy was higher than that of singleton pregnancy in the first, second and third trimesters (P < 0.05), but there was no difference in the TC level between twin pregnancy and singleton pregnancy (P > 0.05). For the twin pregnancy, the TG level in the GDM group was higher than that in the non-GDM group (P < 0.05), while the TC level in the GDM group was not different from that in the non-GDM group (P > 0.05). The TG level in the first, second and third trimester of twin pregnancy combined with PIH group was higher than that in the non-hypertensive group (P < 0.05), while there was no difference in the TC level between the hypertensive group and the non-hypertensive group (P > 0.05).
Conclusions
The lipid levels in twin pregnancy increased with the increase of gestational age, and the TG level in twin pregnancy complicated with GDM or PIH was higher than that in twin pregnancy without with GDM or PIH, indicating that the blood lipid metabolism was related to the occurrence of GDM and PIH in twin pregnancy to some extent.
Adopting simulation-based tools to teach clinical reasoning in medical schools: A qualitative study
Authors: Kassianos Angelos P. , Plackett Ruth , Kambouri Maria , Sheringham Jessica 
Published: June 2022

Abstract
Background: Simulation-Based Medical Education (SBME) methods can be used to teach clinical reasoning (CR) skills and overcome limitations of using face-to-face methods. However, adoption of SBME methods is often challenging. The aim of this study was to explore UK medical educators’ perspectives of what influences adoption of SBME methods to teach CR. Methods: A qualitative research study using semi-structured telephone interviews with medical educators in the UK with control over teaching materials of CR was conducted. The Consolidated Framework for Implementation Research (CFIR), commonly used in healthcare services implementation research was adapted to inform the analysis. Thematic analysis was used to analyse the data. Results: Thirteen medical educators participated in the study. Three themes emerged from the data. Participants’ recognition of situations as opportunities or barriers related to their prior experiences of implementing SBME. For example, participants with experience viewed limited face to face placement as opportunities and often sought to introduce SBME opportunistically. Adoption was influenced by the implementation climate of the setting, including positioning of CR; relationships between faculty particularly where faculty were dispersed. How SBME was framed positioning as additional rather than as a replacement for face-to-face teaching could reduce resistance.Conclusions: By adapting an implementation framework for health services, we were able to identify features of current teaching processes and the implementation climate of medical schools that may be important in the adoption of SBME. These include access to face-to-face teaching opportunities, positioning of clinical reasoning in the curriculum, relationship between educators and institutions and decision-making processes. Our adapted framework may be useful in future studies of implementation in medical education.
The Relationships of Kinesiophobia and Physical Function and Physical Activity Level in Juvenile Idiopathic Arthritis
Authors: Woolnough Leandra , Lentini Logan , Sharififar Sharareh , Chen Cong , Vincent Heather K 
Published: June 2022

Abstract
Background: Kinesiophobia may hinder physical performance measures and functional quality of life in children with juvenile idiopathic arthritis (JIA). This study aims to quantify differences in physical function in patients with JIA compared to healthy controls, and determine the effects of kinesiophobia on physical function and physical activity. Methods. This was a comparative study of participants with JIA and healthy controls (JIA n=26, control n=17). Performance-based measures included gait speed, chair and stair navigation performance. Self-reported measures included Patient Reported Outcome Measurement Information System (PROMIS®) Physical Function Mobility, and Pain Interference and the Pediatric Functional Activity Brief Scale (Pedi-FABS). The Tampa Scale of Kinesiophobia (TSK-11) assessed patient fear of movement due to pain. Linear regression models were used to determine the contribution of TSK-11 scores on performance test and Pedi-FABS scores. Results: Gait speeds were 11%-15% slower, chair rise repetitions were 28% fewer, and stair ascent and descent times were 26%-31% slower in JIA than controls (p<.05). PROMIS® Physical Function Mobility scores were 10% lower and Pain Interference scores were 2.6 times higher in JIA than healthy controls (p=.003). TSK-11 scores were higher in JIA than controls (p<.0001). After controlling for covariates, TSK-11 scores explained 11.7%-26.5% of the variance of regression models for stair climb time, chair rise performance and Pedi-FABS scores (p<.05). Conclusions: Children with JIA experience difficulty with tasks related to body transfers. Kinesiophobia is a significant contributor to the functional task performance and may impact clinical outcomes. Trial Registration: N/A
Education Research: Developing an Inpatient Relationship Centered Communication Curriculum (I-rccc) Rounding Framework for Surgical Teams
Authors: Nassar Aussama K. , Weimer‑Elder Barbette , Yang Rachel , Kline Merisa , Dang Bryan K. , Spain David A. , Knowlton Lisa M , Valdez Andre B. , Korndorffer James R. , Johnson Tyler 
Published: June 2022

Abstract
Background: Morning rounds by an acute care surgery (ACS) service at a level one trauma center are uniquely demanding, given the fast pace, high acuity, and increased patient volume. These demands notwithstanding, communication remains integral to the success of surgical teams. Yet there are limited published curricula that address trauma inpatient communication needs. Observations at our institution confirmed that the surgical team lacked a shared mental model for communication. We hypothesized that creating a relationship-centered rounding conceptual framework model would enhance the provider-patient experience.Study Design: A mixed-methods approach was used for this study. A multi-pronged needs assessment was conducted. Provider communion items for Press Ganey and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys were used to measure patients' expressed needs. Faculty with experience in relationship-centered communication observed morning rounds and documented demonstrated behaviors. A five-hour workshop was designed based on the identified needs. A pre-and post-course Assessment and course evaluation were conducted. Provider-related patient satisfaction items were measured six months before the course and six months after the workshop. Results: Needs assessment revealed a lack of a shared communication framework and a lack of leadership skills for senior trauma residents. Barriers included: time constraints, patient load, and interruptions during rounds. The curriculum was very well received. Press Ganey top box likelihood to recommend (LTR) and provider-related top box items showed a trend towards improvement after implementing the training with a percentage difference up to 20%.Conclusion: The Inpatient Relationship Centered Communication Curriculum (I-RCCC) targeting the senior residents and Nurse Practitioners (NP) was feasible, practical, and well-received by participants. There was a trend of increase in LTRs and provider-specific patient satisfaction items. This curriculum will be further refined based on the study results and potentially scalable to other surgical specialties.
A Novel Algorithm for Imputing the Missing Values in Incomplete Datasets
Authors: Bhagat Hutashan Vishal , Singh Manminder 
Published: June 2022

Abstract
In today’s world, we completely rely on digital devices to collect data; a failure in such digital devices may result in huge information loss thereby making data mining a more tedious job for a Data Analyst. Missingness to a greater extent in a dataset subsequently comes out with inappropriate results and incomplete data analysis. Therefore, a need to develop an algorithm that can predict the missing values efficiently and accurately. This research paper proposes a novel splitting-based IMV-RE (Imputing the Missing Values in Real-Time Environment) algorithm to impute different missing values within a dataset. In the proposed IMV-RE algorithm, an upper limit is set for every class containing missing values that assist the algorithm to predict the missing values more accurately. The experimentation is performed on ten benchmark datasets that include completely numerical values as well as mixed data. Comparative experimental analysis indicates that the proposed IMV-RE algorithm outperforms the existing techniques in sensitivity to Accuracy, Root Mean Square Error (RMSE) and Coefficient of Determination (R2).
Bio Inspired Based Proper resource Allocation (BIB-PA) for energy efficiency using optimization algorithm
Authors: Saini Mehak , Grewal Surender K. 
Published: June 2022

Abstract
Massive MIMO is recognized as an important technology for advancing the deployment of 5th generation and beyond (B5G) networks. In a multi-cell large-scale multi-input multi-output (MIMO) non-orthogonal multi-access (NOMA) network, a base station (BS) with multiple antennas delivers radio frequency energy downlink and Internet of Things (IoT) devices. Uses the collected energy Supports the transmission of data about uplinks. This approach uses wireless power transfer (WPT) to investigate energy efficiency (EE) issues in large multi-cell MIMO NOMA networks. To maximize the EE of the network, we propose a new joint power, time, antenna selection, and subcarrier resource allocation scheme that can appropriately allocate time for power collection and data transmission. Both complete channel state information and incomplete channel state information (CSI) are considered and the corresponding EE performance is analyzed. The EE maximization problem, which is not trivial due to non-convexity, is formulated. First, we apply fractional nonlinear programming to transform the problem into a convex problem, and then we develop an ADMM-based approach (variance alternating direction method of multipliers) to solve this problem. This ADMM is combined with error reduction on the receiving side. Since these data errors are assumed with different channel estimation parameters and their relationship to energy efficiency has not yet been evaluated, a livestock grazing optimization algorithm (CGPO) is used to specify the data size capacity range for each RF link. Introduce error reduction. The proposed CGPO algorithm keeps tracking the error correction and detection process of the receiver for each radio frequency link. Finally, the numerical and analytical results show that the maximal Energy efficiency is achieved by a massive MIMO Systems using BIB-PA approach in the MATLAB platform.
Object Coverage Criteria for Supporting Object-oriented Testing
Authors: Ghoreshi Mohammad , Haghighi Hassan 
Published: June 2022

Abstract
Code coverage criteria are widely used in object-oriented (OO) domains as test quality indicators. However, these criteria are based on the procedural point of view, and therefore, do not address the specific features of OO programs. In this article, we extend the code coverage criteria and introduce a new set of criterion, called “object coverage criteria”, which cope with OO features like object instantiation, inheritance, polymorphism, and dynamic binding. Unlike previous criteria, the new criteria regard the actual type of the object under test and some inherited codes from the parent/ancestor classes that represent the object’s states and behaviors. The new criteria have been implemented in a prototype tool called OCov4J for the Java language. Using this tool and conducting an empirical study on totally 270 classes (with about 50k lines of code without blank lines and comments) from several large and widely used open source projects, we have found a considerable positive correlation between the object coverage level (defined via the new proposed criteria) and the number of detected specific OO failures. Not only the proposed criteria provide ease of use, high automation, and low execution cost, they can effectively be applied to real world object oriented programs.
Contactless Manipulation of Mixed Phase Fluids in Liquid Crystal Polymer Microtubes Assisted with Light-Driven Vortex
Authors: Yu Yanlei , Lu Yao , Qin Lang , Liu Quan , Li Zichuan , Zhang Weijia , Zhu Chongyu 
Published: June 2022

Abstract
Smart channels that manipulate liquid motion by anisotropic shape change represent a promising candidate to construct microfluidics for biochemical analysis. However, the existing systems fail to provide a platform for solid exchange mediums to interact with multiple liquid phases, which is a universal technique to effectively extract, enrich and precisely detect biomarkers. Herein, a photo/magnet-combined control strategy of mixed phase fluids, which integrates the contactless manipulation of suspending, depositing, and even separating, is first reported based on the trilayer microtube consisting of flexible supporting layer, photodeformable liquid crystal polymer, and hydrophilic blocking layer. The asymmetric photodeformation of the liquid crystal polymer generates an internal vortex in the microtube to homogenously disperse solid exchange mediums into various aqueous moving droplets, and to enable efficient purification and enrichment of the target biomarkers. A newly constructed homemade portable protein analyzer guided by the photo/magnet-combined control strategy features advantages of short detection time (20 min), trace sample consumption (5 µL), and low detection limit (1 µg mL-1).
Serotype-Specific Transduction of Canine Joint Tissue Explants and Cultured Monolayers by Self-Complementary Adeno-Associated Viral Vectors
Authors: Kim Ah young , Goodrich Laurie , Duerr Felix , Phillips Jennifer , Samulski Richard , Grieger Josh 
Published: June 2022

Abstract
A formal screening of self-complementary adeno-associated virus (scAAV) vector serotypes in canine joint tissues has not been performed to date. Selecting appropriate serotypes is crucial for successful treatment due to their varying levels of tissue tropism. The objective of this study is to identify the most optimal scAAV vector serotype that maximizes transduction efficiencies in canine cell monolayer cultures (chondrocytes, synoviocytes, and mesenchymal stem cells) and tissue explant cultures (cartilage and synovium). Transduction efficiencies of scAAV serotypes 1, 2, 2.5, 3, 4, 5, 6, 8, and 9 were evaluated in each culture type in three different vector concentrations by encoding a green fluorescent protein. It was found that scAAV2 and 2.5 showed the overall highest transduction efficiency among serotypes with dose-response. Since possible immune response against conventional AAV2 was previously reported in dogs, the chimeric scAAV2.5 may be more suitable to use. Evaluation of the safety and efficacy of the scAAV2.5 vector with an appropriate therapeutic gene in vivo is indicated.
Can Azolla filiculoides be a complementary feed resource for ecological intensification in small-scale fish farming? Biological effects on giant gourami (Osphronemus goramy)
Authors: Caruso Domenico , Lusiastuti Angela Mariana , Pouil Simon , Samsudin Reza , Arifin Otong Zenal , Slembrouck Jacques 
Published: June 2022

Abstract
Juveniles of giant gourami Osphronemus goramy Lacépède (1801) were fed for six weeks with different proportions of fresh Azolla (A100% B56% C26% and D0% of replacement). The condition factor (KFulton) somatic and immunological indicators were measured. Effects of Azolla on transport stress and bacterial infection with Aeromonas hydrophila were also assessed. Results showed that KFulton decreased with increasing proportions of Azolla in the diet (p < 0.001). Total protein, albumin and globulin in fish fed exclusively with Azolla (treatment A) were significantly lower than in the other treatments. A significant decrease in lymphocytes was observed in treatments A and B (p < 0.001) and fish from these treatments had significantly higher levels of monocytes (p < 0.001). Neutrophils were significantly higher in treatment A only (p = 0.012). Plasma lysozyme levels and serum bactericidal activity increased significantly with Azolla in the diet (both p < 0.001). Before transport stress, blood glycaemia was significantly lower in fish from treatment A (p < 0.001), after transport, glycaemia increased significantly only in treatments B, C and D (p < 0.001) and fifteen days after, survival was significantly higher in fish from treatment A. One week after experimental infection the survival of fish from treatments A and B was significantly higher than for fish from treatments C and D (p < 0.001). Results suggest that A. filiculoides has positive effects on fish immunological indicators, and resistance to stress and disease but decreases growth performance. We recommend that the replacement of commercial pellets with A. filiculoides should not exceed 30%.
Spiritual well-being correlates with quality of life of both cancer and non-cancer patients in palliative care -further validation of EORTC QLQ-SWB32 in Finnish
Authors: Goyarrola Raimo , Lipsanen Jari , Saarelainen Suvi-Maria , Suviranta Raili , Rahko Eeva , Lamminmäki Annamarja , Klaavuniemi Tuula , Ahtiluoto Satu , Ohvanainen Antti , Metso Pekka , Pöyhiä Reino 
Published: June 2022

Abstract
Background: The European Organisation for Research and Treatment of Cancer (EORTC) has developed the Spiritual Well-being Questionnaire (EORTC QLQ-SWB32) for assessment of spirituality in palliative care for cancer. We aimed to translate and validate this tool in Finnish and to study the relationship between spirituality and quality of life (QOL). Methods: Finnish translation was produced according to the guidelines of EORTC and included forward- and back-translations. Face-, construct- and convergence/divergence validity and reliability were studied in a prospective manner. QOL was assessed with EORTC QLQ-C30 and 15D questionnaires.Sixteen individuals participated in the pilot testing. 101 patients with cancer from oncology units, and 89 individuals with other chronic diseases from spiritual communities participated in the validation part in different parts of the country. Sixteen people participated in the retest phase. Inclusion criteria were that the individual had either a defined palliative care plan or suitability to a such plan, as well as capability to understand and communicate in Finnish. Results: The translation appeared understandable and acceptable. The factorial analysis identified four scoring scales with high Cronbach alfa values: Relationship with Self (0.73), Relationship with Others (0.84), Relationship with Something Greater (0.82), Existential (0.81), and, additionally, a scale on Relationship with God (0.85). There was a significant correlation between spiritual well-being and QOL in all participants. Conclusions: Spiritual well-being is correlated with QOL in cancer and non-cancer patients eligible for palliative care. The Finnish translation of EORTC QLQ-SWB32 is a valid and reliable measure both for research and clinical practice.
Ultrasonography is an effective tool for the evaluation of traumatic vertebral artery injuries in the emergency room
Authors: Ishimoto Yuyu , Iwasaki Hiroshi , Sonekatsu Mayumi , Murata Shizumasa , Kozaki Takuhei , Hashizume Hiroshi , Tsutsui Shunji , Takami Masanari , Nagata Keiji , Hira Kazuhiro , Kato Seiya , Yamada Hiroshi 
Published: June 2022

Abstract
ObjectivesThis study aimed to determine the feasibility of ultrasonography (US) in the assessment of cervical vertebral artery (VA) injury compared with computed tomography angiography (CTA) in the emergency room.MethodsA total of 50 VAs from 25 consecutive patients with cervical spine injury admitted to the emergency room in our hospital were analyzed in this study. US and CTA were performed to assess the VA in patients with cervical spine injury, and the sensitivity and specificity of US for CTA was clarified.ResultsThe agreement between US and CTA was 98% (49/50) with 0.92 Cohen's Kappa index. The sensitivity, specificity, and positive and negative predictive values of US were 100%, 97.7%, 85.7%, and 100%, respectively.ConclusionsUS had a sensitivity of 100% compared with CTA in assessment of the VA. It can be used as an initial screening test for VA injury in the emergency room.
Analysis of the Effects of Simplifications on the State of Loads in a Centrifugal Compressor
Authors: Bednarz Arkadiusz , Sęp Jarosław , Bartłomowicz Rafał , Jaworski Justin , Wójcik Augustyn 
Published: June 2022

Abstract
This study aims to quantify and assess qualitatively the impact of modeling simplifications used to represent inertial and aerodynamic loads on the stresses and structural deformations of a centrifugal compressor in operation. The research object is the compressor of the high-pressure line of the DGEN 380 bypass turbine engine. Based on the virtual dynamometer WESTT CS/BV, the gas-dynamic parameters at the entrance to the centrifugal compressor and after the stage are determined. These values were used as initial parameters for numerical flow analysis. As part of the numerical strength analyses, a series of several load configurations were carried out: spin only, spin and inlet pressure normally applied on the working surface of the rotor blade, spin and outlet pressure normally applied on the working surface of the rotor blade, and one-way fluid-structure interaction analysis taking into account the aerodynamic loads with and without spinning. Based on the simulations, the level of similarity of a given load configuration with the last analysis, adopted as the reference, was determined. It was observed that in terms of the stress state, the rotational analysis taking into account the pressure on both sides of the blade gives satisfactory results, but the strain values are overestimated. The results obtained and the method of evaluation of compressor results can be used in research in the area of aviation, automotive, and refrigeration industries.