bluuebunny/crossref_metadata_2025_split huggingface dataset:
HASIL BELAJAR DAN KETERAMPILAN GENERIK SAINS PADA PENGGUNAAN CULTURE LITERACY DIGITAL WETLAND LKPD KONSEP VERTEBRATA SISWA KELAS X SMA
Authors: Safitri Safitri , Putra Aminuddin Prahatama , Ajizah Aulia 
Published: June 2022

Culture Literacy Digital Wetland (CLDW) is a software that’s used to create web-based online course materials and manage learning activities and their results as is the case with the Learning Management System. This study aims to; (1) describe the effect of using CLDW LKPD on the vertebrate concept on students' cognitive learning outcomes, and (2) describe the effect of using CLDW LKPD on the verte-brate sub-concept on students' generic science skills. This study uses a quasi-experimental approach with Pretest Posttest Control Group Design for cognitive learning outcomes and Posttest-only Control Group Design for science generic skills. The research sample was students of class X MIPA 1 as the ex-perimental class and X MIPA 2 as the control class. Testing the use of CLDW LKPD on learning out-comes using the analysis of covariance test from the results of the Pretest Posttest, and generic science skills using the independent sample T-test test from the student worksheets. The results showed; (1) there was an effect of using CLDW LKPD on students' cognitive learning outcomes (sig. 0.010), and (2) there was an effect of using CLDW LKPD on students' generic science skills (sig. 0.004). It is hoped that from the results of the research, the use of CLDW LKPD can be used as an alternative, especially in online learning.Keywords: CLDW LKPD, cognitive learning outcomes, science generic skills, vertebrates. ABSTRAKCulture Literacy Digital Wetland (CLDW) merupakan perangkat lunak yang digunakan untuk membuat materi pelajaran online berbasis web dan mengelola kegiatan pembelajaran serta hasil-hasilnya seperti halnya pada Learning Management System. Penelitian ini bertujuan untuk; (1) mendeskripsikan pengaruh penggunaan CLDW LKPD pada sub konsep vertebrata terhadap hasil belajar kognitif peserta didik dan (2) mendeskripsikan pengaruh penggunaan CLDW LKPD pada konsep vertebrata terhadap keterampilan generik sains siswa peserta didik. Penelitian ini menggunakan pendekatan quasi experiment dengan desain pretest posttest control group design untuk hasil belajar kognitif dan posttest-only con-trol group design untuk keterampilan generik sains. Sampel penelitian adalah peserta didik kelas X MIPA 1 sebagai kelas eksperimen dan X MIPA 2 sebagai kelas kontrol. Pengujian penggunaan CLDW LKPD terhadap hasil belajar menggunakan uji analysis of covariance dari hasil pretest-posttest, dan keterampilan generik sains menggunakan uji independent sample T-test dari lembar kerja peserta didik. Hasil penelitian menunjukkan; (1) terdapat pengaruh penggunaan CLDW LKPD terhadap hasil belajar kognitif produk peserta didik (sig. 0,010) dan (2) terdapat pengaruh penggunaan CLDW LKPD terhadap keterampilan generik sains peserta didik (sig. 0,004). Diharapkan dari hasil penelitian, penggunaan CLDW LKPD dapat dijadikan sebagai alternatif terutama dalam pembelajaran daring.Kata kunci: CLDW LKPD, hasil belajar kognitif, keterampilan generik sains, vertebrata.
Frecuencia de terceros molares retenidos con relación al biotipo facial. un estudio transversal
Authors: Zeta Rodríguez Taylor Augusto 
Published: June 2022

Objetivo: Identificar la frecuencia de terceros molares retenidos con relacion al biotipo facial utilizando estudios 2D (panoramicos y cefalometricos) de pacientes que acudieron al centro de imagenes Zeta-Exmed en el periodo de noviembre de 2018 a diciembre de 2021, en la ciudad de Lima, Peru. Metodologia: El tipo de estudio de esta investigacion fue observacional, descriptivo, transversal y retrospectivo. Se evaluaron 6000 casos, cada uno compuesto de una imagen radiografica panoramica y una cefalometrica, ambas tomadas al paciente en la misma fecha, de las cuales solo fueron incluidos en la investigacion un total de 150 casos, por cumplir con los criterios de seleccion. Las mediciones sobre la frecuencia de terceros molares retenidos con relacion al biotipo facial se realizaron por un investigador entrenado y calibrado, utilizando el software Nemoceph para los trazados cefalometricos. Se utilizo para el analisis estadistico el programa SPSS version 1.0.0.1401 (SPSS Inc., EE. UU.) y la prueba chi cuadrado (p < 0,05). Resultados: De los 150 casos revisados, 91 correspondieron al sexo femenino (60,66%) y 59 al sexo masculino (39,33%), lo que dio como resultado que el biotipo dolicofacial se presento con mayor frecuencia en estos, con un total de 27 casos (45,80%), mientras que, en mujeres, el biotipo braquifacial fue el de mayor frecuencia, con un total de 35 casos (38,50%). Asimismo, del total de terceros molares retenidos evaluados (403 piezas), 141 se presentaron en casos con biotipo dolicofacial, seguido del biotipo mesofacial con 139 piezas y, finalmente, el biotipo braquifacial con 123 piezas. Respecto de la evaluacion de los terceros molares retenidos en relacion con su posición y biotipo facial, se encontro 63 3MR en posicion mesioangular y 28 en posicion distoangular en dolicofacial, seguidos de 48 piezas en posicion vertical en braquifacial. Conclusiones: No existe una relacion significativa entre la cantidad de terceros molares retenidos y su posicion, en relacion con el biotipo facial, pero si respecto a la relacion entre el sexo y el biotipo facial, pues los varones presentan un biotipo dolicofacial con mayor frecuencia y las mujeres el biotipo braquifacial.
A Clinical Study of Liposuction combined with Lymphovenous Anastomosis for Treatment of Breast Cancer-Related Lymphedema
Authors: Chang Kun , Xia Song , Liang Chen , Sun Yuguang , Xin Jianfeng , Shen Wenbin 
Published: June 2022

Abstract
Objective
In this work, we studied the clinical effect of liposuction combined with lymphovenous Anastomosis (LVAs) for treatment of breast cancer-related lymphedema (BCRL).
Methods
We studied 158 patients with unilateral upper limb BCRL underwent liposuction combined with LVAs. Arm circumferences before and 7 days after the combined treatments were prospectively recorded. Circumferences of different upper extremities were measured before the procedure, 7 days after LVAs and during the follow-ups. Volumes were calculated with the frustum method. During the follow-ups, the conditions of patients’ treated arms, i.e. the frequency of erysipelas episodes and dependence on compression garments, were recorded.
Results
The mean circumference difference between two upper limbs decreased significantly from M (P25, P75) 5.3 (4.1, 6.9) preoperatively to 0.5 (-0.8, 1.0) (P < 0.01)7 days after treatments, while at follow-up 0.3 (-0.4,1.0). The mean volume difference decreased significantly from M (P25, P75) 838.3(662.4, 1129.0)preoperatively to 7.8 (-120.3, 151.4) (P < 0.01)7 days after treatments, while at follow-up 43.7 (-59.4,161.1). The incidence of erysipelas also significantly decreased (P < 0.01). 6.3% patients were already independent of compression garments during the past six months or even more.
Conclusion
Liposuction combined with LVAs is an effective method for the treatment of BCRL.
Concoction of CAPE and Crocin augments anti-cancer potential and realigns the expression paradigm of p53, EGFR and PCNA in U87-MG Glioma cells
Authors: Mir Ashaq Hussain , Mir Khurshid Iqbal , Banday Mujeeb Zafar , Balkhi Henah Mehraj , Haq Ehtishamul 
Published: June 2022

Abstract
Objective: An adjunct is expected to be identified through this study that will be used alone or in combination with the existing therapeutic regimen for the treatment of gliomas. Results: CAPE and Crocin when used in a congruous combination and durations, present an anticancer potential for glioma. CAPE and Crocin in combination have been shown to inhibit proliferation and induce apoptosis in U87-MG glioma cells. Our results provide evidence that combination treatment realign the expression paradigm of p53, EGFR and PCNA in co-treated U87-MG cells. Compared to efficacy of a single drug, combination of CAPE and Crocin has revealed significant antineoplastic effectiveness in treating gliomas. Together, co-treatment augments effectiveness and halt glioma invasion and proliferation significantly. This implies that the treatment of glioma with combination of the drugs could be considered in prospective therapeutic algorithm for the curative treatment of gliomas.
Effect of wearing medical protective masks on treadmill running performance in the postpandemic era: a randomised trial
Authors: Wang I-Lin , Su Yu , Yao Shun , Wu Chou , Lai Chien-Ying 
Published: June 2022

Abstract
In the postpandemic era, wearing protective masks in public places will still be an important means of blocking popular viruses in the future. (1) Background: The purpose of this study was to explore whether sports performance was affected by mask wearing and exercise duration during 15-minute treadmill running at a speed of 75% maximal aerobic speed. (2) Methods: Thirty-six males were randomly divided into mask and nonmask groups. The kinematic and kinetic data were obtained at four time points (RN0-1 min, RN5-6 min, RN9-10 min, and RN14-15 min) after running. Two-way repeated-measures ANOVA was applied to examine the effects between groups and times with Bonferroni post hoc comparison. (3) Results: The results showed that there was no difference between mask and nonmask group during running (p > 0.05). As running time increased, hip joint ROM, hip joint flexion/extension max, and ankle joint plantarflexion max angles increased; knee joint flexion min and ankle joint dorsiflexion max angles decreased; average peak vertical ground reaction forces (PVGRF) increased after 9 min-running (p < 0.05). (4) Conclusions: Wearing a medical protective mask does not affect the joint angle and touchdown PVGRF of lower extremities during treadmill running while affected by running time and changed after 9 min-treadmill running. Future studies will examine the effects of wearing masks during the pandemic on muscle activation and blood biochemical values during exercise. The trial was registered prospectively with trial registration number (TRN) of ChiCTR2000040535 and date of registration in December 1, 2020.
Aerobic exercise alleviates ventilator-induced lung injury due to activation of NLRP3 inflammasome
Authors: Liu Mengjie , Yan Jie , Wang Yuelan 
Published: June 2022

Abstract
BackgroundVentilator-induced lung injury (VILI) is a type of lung injury caused by stretch stimulation and other reasons for mechanical ventilation. NOD-like receptor protein 3(NLRP3) is an important ingredient of innate immunity and is strongly associated with VILI. This paper aims to investigate the effect of aerobic exercise on VILI and the role of NLRP3.MethodsC57BL/6 male mice (7-week-old, 19~23g) were pre‐treated with Bisindolylmaleimide I (specific and highly efficient inhibitor of PKC) . Then the mice were subjected to mechanical ventilation at a high tidal volume. For another study, the mice were randomly divided into the following four groups:control group (C group), mechanical ventilation group (MV group), exercise group (EX group) and exercise + mechanical ventilation group (EX+MV group) which were subjected to mechanical ventilation or 5 weeks of aerobic exercise training. At the end of ventilation, hematoxylin-eosin (HE) staining and wet/dry weight ratio were used to access the pathophysiological changes of lung tissues. The expression of PKCɑ, P-PKCɑ,ASC,Procaspase-1,caspase-1,ProIL-1β,IL-1β,NLRP3 and tight junction protein occludin in lung tissues were determined by Western blot. The contents of IL-6 in alveolar lavage fluid were determined by ELISA.ResultsMechanical ventilation could increase the levels of NLRP3, P-PKCɑ, PKCɑ, while these changes could be reversed by Bisindolylmaleimide I. Inhibited the PKC production can prevented the activation of NLRP3. Moreover, mechanical ventilation also could increase the levels of ASC,Procaspase-1,caspase-1,ProIL-1β,IL1β and decrease the levels of occludin, while these changes could be alleviated by aerobic exercise. HE staining and lung injury scores all confirmed that no obvious lung injury to group C and EX, while the severity of lung injury was the severest in group MV but was improved on group EX+MV.Taken together, these findings suggest that mechanical ventilation activated the NLRP3 inflammasome by activating PKCɑ, induced the degradation of occludin; while aerobic exercise attenuated activation of NLRP3 inflammasome and PKCɑ and mitigated the decrease in occludin expression caused by mechanical stretch.ConclusionActivation of NLRP3 leads to acute lung injury. Aerobic exercise can reduce lung injury by inhibiting activation of PKCɑ and NLRP3, suggesting a potential preventive measure for the clinical treatment of VILI.
Performance Comparison of Various EBG Structures
Authors: latha prema , Gammadi srikanth , Rangasai Kiriti 
Published: June 2022

Abstract
This paper mainly deals with performance comparison of various EBG antennas for WIFI applications.The proposed designshave a size of 28.11x32.40x1.59 mm3with RT / Duroid 5880 substrate having a thickness of 1.59mm and Ɛr = 2.2. In recent years the use of electromagnetic band gap structures, has grown rapidly in the antenna designs due to its unique properties. EBG structures are used in the antenna to enhance its performance characteristics. In this paper variousEBG antennasare designed and replicated using HFSS software. Various EBGs like Fork, Fractal, Spiral are placed on Ground plane and on the patch. Performance parameters such as return loss, radiation patterns and Gain are measured and are reported.
Clinical analysis of risk factors of acquired immunodeficiency syndrome complicated with pulmonary tuberculosis
Authors: She Li-jun , Zhang Xin , Liu Shi-fu , Ma Jian-hui , Cao Jin-feng 
Published: June 2022

Abstract
Objective
To analyze the risk factors of acquired immunodeficiency syndrome(AIDS)complicated with pulmonary tuberculosis༈PTB༉, so as to provide a reference for better treatment and prevention .
Methods
A retrospective analysis of 939 AIDS patients admitted to our hospital from January 2016 to January 2021 was divided into AIDS combined PTB group (group A, 68 cases) and AIDS group (group B, 871 cases) according to whether they were complicated with PTB. The clinical and laboratory data were analyzed and compared between the two groups.
Results
There were no significant differences between the two groups in gender, residence, occupation, annual income, educational level, marital status, drinking history, history of diabetes, history of BCG vaccination, homosexuality, and whether there were multiple sexual partners at the same time (P > 0.05). ). There were significant differences in smoking history and the number of CD4 + cells (200 cells/mm3 as the boundary), with χ2 = 8.98 and χ2 = 9.65, respectively, P < 0.05.
Conclusion
Smoking history and CD4 + cell count < 200 cells/mm3 were risk factors for AIDS complicated with PTB.
BYSL: A Novel Biomarker for Cancer Treatment
Authors: Li Yuqing , Li Kexin , Zou Jiahua , An Ran , Xu Fang , Liu Zhong 
Published: June 2022

Abstract
Background: BYSL, Bystin like, was previously characterized as an important gene for cell proliferation, migration, invasion, and mesenchymal transformation in human carcinoma. However, systematic pan-cancer analysis of BYSL has never been developed to comprehend its regulation in cancer so far.Methods: The potential carcinogenic role of BYSL in 33 carcinomas based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) dataset, Tumor Immune Estimation Resource (TIMER), Human Protein Atlas (HPA), and Gene Set Enrichment Analysis (GSEA) datasets.Results: In most tumors, BYSL expression is high and correlated with prognosis. Furthermore, BYSL gene alterations, bystin like protein phosphorylation, and bystin DNA methylation are linked to many types of tumorigenesis and immune invasion. Thirdly, translation and viral carcinogenesis may contribute to BYSL's tumor-pathogenic effects.Conclusions: Based on the results of the bioassay used in this study, BYSL may have potential as a biomarker to differentiate tumor tissue from normal tissue in most cancer patients, providing new research clues of how BYSL is regulated and thus the development of targeted therapies.
Assessment of heavy metals pollution in marine sediments from southwest of Mallorca island, Spain
Authors: Ardila Pedro Agustín Robledo , Alonso Rebeca Álvarez , Valsero Juan José Durán , García Raquel Morales , Cabrera Flor Árcega , Cosío Elizabeth Lamas , Laforet Sergio Raúl Durán 
Published: June 2022

Abstract
Anthropogenic activities in the urban, agrarian, or industrial areas are the main cause of heavy metals in sediments worldwide. Since the 1960s there have been submarine discharges through outfalls of poorly treated or untreated wastewater on the south coast of Mallorca island (Mediterranean Sea). In this study, the pollution of marine sediments is analyzed at a great number of points on the south of the seacoast. Heavy metals concentrations of As, Ba, Cd, Cr, Cu, Hg, Ni, Pb, Se, V, Zn, Total Inorganic Carbon (TIC), Sulfur, mineralogy, and grain size were analyzed. The objective is to evaluate the concentrations of toxic substances and their spatial distribution and the ranges that can negatively affect marine ecosystems and human health. In addition, the results obtained have been compared with standardized indices for marine sediments and a regional index has been developed with the background values of heavy metals obtained in the sediments of the study area. To obtain consistent conclusions, concentrations of heavy metals were classified with the Igeo Index. The concentrations of heavy metals obtained show as a great number of samples exceeded the limits considered for uncontaminated sediments according to the index applied. Elements such as Hg, Ba, Pb, and Cu showed high concentrations close to the outfalls and lower concentrations in zones far from these points. To support the assessment chemical processes, such as dissolution or chemical precipitation have been studied. The results also show as marine sediments can be a good trap for chemical elements and a good proxy to analyze the impact of anthropogenic activities in areas heavily pressured by humans, and the risk to the environment and human health.
Macroeconomy Driven By Climate Change
Authors: Toh Tze-Chuen 
Published: June 2022

Abstract
A simple econometric model predicting the effects of key drivers of climate change on the real GDP is constructed. It shows quantitatively how GDP is affected by carbon dioxide emissions and energy produced from renewable sources (excluding hydroelectricity). Moreover, the model also demonstrates that increasing energy consumption using fossil fuels at the expense of renewable sources negatively impacts GDP.JEL Classification: C51 , C52 , C53 , O44 , Q54
Research on Rose Classification Based on Neural Network Model
Authors: Hui Jiaojiao 
Published: June 2022

Abstract
As an important industry in China, rose has extremely important economic value and ornamental value. However, affected by human factors and planting environment, even roses of the same variety will have different levels of classification. In order to solve the low efficiency of wrong classification and missing classification caused by manual visual classification and realize the transformation of rose classification from manual judgment to machine independent recognition, this paper first performs data enhancement, image naming and other operations on 200 manually photographed yellow rose images of 5 levels of the same variety, and constructs an image database. Then, in Python language and tensorflow2.0 deep learning tool, design rose classification algorithm based on artificial neural network(ANN), rose classification algorithm based on convolution neural network(CNN) and rose classification algorithm based on feature extraction(FE) and artificial neural network(ANN). Finally, the experimental results show that the third algorithm significantly speeds up the running speed and significantly improves the average recognition rate compared with the first two algorithms, which effectively solves the problems of wrong or missing classification and low classification efficiency in manual intuitive classification, and realizes the transformation from manual classification to machine independent classification.
Adherence Therapy for adults with type 2 diabetes: a feasibility study of a randomised controlled trial
Authors: Alenazi Fatimah , Peddle Monica , Bressington Daniel , Mahzari Moeber , Gray Richard 
Published: June 2022

Abstract
BackgroundAdherence Therapy is a candidate intervention to promote consistent medication taking in people with type 2 diabetes. The aim of this study was to establish the feasibility of conducting a randomised controlled trial of Adherence Therapy in people with type 2 diabetes who were non-adherent with medication.MethodsAn open-label, single-centre, randomised controlled feasibility trial. Participants were randomly allocated to receive either eight sessions of telephone delivered Adherence Therapy or treatment as usual. Recruitment occurred during the COVID-19 pandemic. Outcome measures – adherence, beliefs about medication and HbA1c – were administered at baseline and after eight weeks or at the completion of treatment. Feasibility outcomes included the number of people initiated to participate in the trial that consented, completed study measures, finished treatment with adherence therapy, and dropped out of the trial.ResultsSeventy-eight people were screened of which 39 met eligibility criteria and were invited to take part in the trial. Thirteen people consented to participate, were enrolled in the trial and randomised. Five (71%) of the seven participants in the Adherence Therapy arm completed treatment. Baseline measures were completed by all participants. Week 8 (post-treatment) measures were completed by eight (62%) participants. Drop out may have been linked with a poor understanding of what was involved in taking part in the trial.ConclusionsIt may be feasible to conduct a full RCT of Adherence Therapy, but careful consideration should be given to developing effective recruitment strategies, consent procedures, rigorous field testing and clear support materials.Trial registrationThe trial was prospectively registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12619000827134, on the 7th June 2019.