bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of X-ray induced radiation damage on FD-MAPS of the ARCADIA project
Authors: Neubüser C. , Corradino T. , Mattiazzo S. , Pancheri L. 
Published: January 2022

Abstract
Recent advancements in Monolithic Active Pixel Sensors (MAPS) demonstrated the ability to operate in high radiation environments of up to multiple kGy’s, which increased their appeal as sensors for high-energy physics detectors. The most recent example in such application is the new ALICE inner tracking system, entirely instrumented with CMOS MAPS, that covers an area of about 10 m2. However, the full potential of such devices has not yet been fully exploited, especially in respect of the size of the active area, power consumption, and timing capabilities.
The ARCADIA project is developing Fully Depleted (FD) MAPS with an innovative sensor design, that uses a proprietary processing of the backside to improve the charge collection efficiency and timing over a wide range of operational and environmental conditions. The innovative sensor design targets very low power consumption, of the order of 20 mW cm−2 at 100 MHz cm−2 hit flux, to enable air-cooled operations of the sensors. Another key design parameter is the ability to further reduce the power regime of the sensor, down to 5 mW cm−2 or better, for low hit rates like e.g. expected in space experiments. In this contribution, we present a comparison between the detector characteristics predicted with Technology Computer Aided Design (TCAD) simulations and the ones measured experimentally. The comparison focuses on the current-voltage (IV) and capacitance-voltage (CV) characteristics, as well as noise estimated from in-pixel capacitances of passive/active pixel matrices. In view of the targeted applications of this technology, an emphasis is set on the modeling of X-ray induced radiation damage at the Si-SiO2 interface and the impact on the in-pixel sensor capacitance. The so-called new Perugia model has been used in the simulations to predict the sensor performance after total ionizing doses of up to 10 Mrad.
Pixel readout IC for CdTe detectors operating in single photon counting mode with interpixel communication
Authors: Grybos P. , Kleczek R. , Kmon P. , Krzyzanowska A. , Otfinowski P. , Szczygiel R. , Zoladz M. 
Published: January 2022

Abstract
This paper presents a readout integrated circuit (IC) of pixel architecture called MPIX (Multithreshold PIXels), designed for CdTe pixel detectors used in X-ray imaging applications. The MPIX IC area is 9.6 mm × 20.3 mm and it is designed in a CMOS 130 nm process. The IC core is a matrix of 96 × 192 square-shaped pixels of 100 µm pitch. Each pixel contains a fast analog front-end followed by four independently working discriminators and four 12-bit ripple counters. Such pixel architecture allows photon processing one by one and selecting the X-ray photons according to their energy (X-ray colour imaging). To fit the different range of applications the MPIX IC has 8 possible different gain settings, and it can process the X-ray photons of energy up to 154 keV. The MPIX chip is bump-bonded to the CdTe 1.5 mm thick pixel sensor with a pixel pitch of 100 µm. To deal with the charge sharing effect coming from a thick semiconductor pixel sensor, multithreshold pattern recognition algorithm is implemented in the readout IC. The implemented algorithm operates both in the analog domain (to recover the total charge spread between neighboring pixels, when a single X-ray photon hits the border of the pixel) and in the digital domain (to allocate a hit position to a single pixel).
The ABALONE photosensor
Authors: D’Andrea V. , Biondi R. , Ferrari C. , Ferella A.D. , Mahlstedt J. , Pieramico G. 
Published: January 2022

Abstract
The ABALONE is a new type of photosensor produced by PhotonLab, Inc. with cost effective mass production, robustness and high performance. This modern technology provides sensitivity to visible and UV light, exceptional radio-purity and excellent detection performance in terms of intrinsic gain, afterpulsing rate, timing resolution and single-photon sensitivity. For these reasons, the ABALONE can have many fields of application, including particle physics experiments, such as DARWIN, and medical imaging. This new hybrid photosensor, that works as light intensifier, is based on the acceleration in vacuum of photoelectrons generated in a traditional photosensor cathode and guided towards a window of scintillating material that can be read from the outside through a silicon photomultiplier. In this work we present the simulation of the ABALONE and the results from operation at room temperature. The goal of the characterization is the evaluation of the gain, the response in time and the single photoelectron spectrum as a function of the electric field and the photoelectron emission angle. Details of future tests will be also discussed.
Smart delivery of poly-peptide composite for effective cancer therapy
Authors: Yuan Xin , Qin Yingzhou , Tian Qingmei , Liu Cuijuan , Meng Xiangzhou , Qie Bo , Gao Fan , Huang Ying , Xu Guanghui , Yang Guang , Zhu Yimin 
Published: January 2022

Abstract
In the past decade, multifunctional peptides have attracted increasing attention in the biomedical field. Peptides possess many impressive advantages, such as high penetration ability, low cost, and etc. However, the short half-life and instability of peptides limit their application. In this study, a poly-peptide drug loading system (called HKMA composite) was designed based on the different functionalities of four peptides. The peptide compositions of HKMA composite from N-terminal to C-terminal were HCBP1, KLA, matrix metalloproteinase-2 (MMP-2)-cleavable peptide and albumin-binding domain. The targeting and lethality of HKMA to NSCLC cell line H460 sphere cells and the half-life of the system were measured in vivo. The results showed that the HKMA composite had a long half-life and specific killing effect on H460 sphere cells in vitro and in vivo. Our result proposed smart peptide drug loading system and provided a potential methodology for effective cancer treatment.
Recurrence relations for off-shell Bethe vectors in trigonometric integrable models
Authors: Liashyk A , Pakuliak S Z 
Published: January 2022

Abstract
The zero modes method is applied in order to get the action of the monodromy matrix entries on off-shell Bethe vectors in quantum integrable models associated with

U

q

(

g
l

N

)

-invariant R-matrices. The action formulas allow to get recurrence relations for off-shell Bethe vectors and for highest coefficients of the Bethe vectors scalar product.
Heterogeneous diffusion with stochastic resetting
Authors: Sandev Trifce , Domazetoski Viktor , Kocarev Ljupco , Metzler Ralf , Chechkin Aleksei 
Published: January 2022

Abstract
We study a heterogeneous diffusion process (HDP) with position-dependent diffusion coefficient and Poissonian stochastic resetting. We find exact results for the mean squared displacement and the probability density function. The nonequilibrium steady state reached in the long time limit is studied. We also analyse the transition to the non-equilibrium steady state by finding the large deviation function. We found that similarly to the case of the normal diffusion process where the diffusion length grows like t
1/2 while the length scale ξ(t) of the inner core region of the nonequilibrium steady state grows linearly with time t, in the HDP with diffusion length increasing like t

p/2 the length scale ξ(t) grows like t

p
. The obtained results are verified by numerical solutions of the corresponding Langevin equation.
Permeable Reactive Concrete Using Recycled Waste Materials for Nutrient Contamination Removal in Urban Surface Runoff
Authors: Cruz G. , Lingad M. 
Published: January 2022

Abstract
In recent years, stormwater control measures (SCMs) such as permeable concrete pavement have been experimentally investigated and used to manage hydrologic and water quality impacts of stormwater runoff. Research revealed the potential of permeable pavement in reducing and delaying peak flow rate, reducing runoff volume, and capturing heavy metals and other particulate-bound pollutants from stormwater runoff. However, few studies have evaluated the effects of permeable pavement on nutrients in stormwater runoff. This research aims to produce permeable reactive concrete (PRC) from waste fly ash, waste gypsum board and waste coco peat and to investigate its effectiveness in removing nutrient contamination present in stormwater or urban surface runoff. The raw materials underwent through granulation process to produce granulated filtering media (GFM). Cylindrical samples of PRC were then made and subjected to various physical and water quality tests. The use of GFM as partial coarse aggregates of PRC for urban surface runoff management and nutrient contamination removal has been tested and evaluated. After performing all the tests, the researchers concluded that GFM as partial coarse aggregates of PRC is effective due to the significant increase in infiltration rate of the entire sample compared to the traditional permeable concrete that has an average infiltration rate of 2-6 mm/s. The results in the water quality test revealed that PRC with GFM as partial coarse aggregates lessen the nitrate, phosphate, and ammonia that are present on urban surface runoff.
An AI-Based Query System for Historical Weather Radar Reflectivity Retrieval Using a Convolutional Auto-encoder
Authors: Fahn C S , Chiang C C , Hsieh P C , Lin C Y , Tsau S K 
Published: January 2022

Abstract
The weather patterns in Taiwan have been more changeable in recent years. Taking rainfall as an example, natural disasters that lead to major damage are often caused by heavy rainfall in a short period of time. Therefore, how to effectively predict changes in weather patterns has become an important issue for the development of disaster prevention technology. In this paper, an AI-based query system using a convolutional auto-encoder is developed for historical weather radar reflectivity retrieval that is expected to forecast heavy rainfall soon. When the weather radar receives a current radar reflectivity, meteorologists can employ the query system to quickly search for the historical radar reflectivity with the weather characteristics similar to the one to be queried. The experimental results reveal that under the given MSE threshold of 58,000, the average pass rate achieves 83.9% for the ranked top 10 similar results from 33,461 historical records via 4,319 query tests in total. Without considering the model loading time of 60 seconds, the execution time of each query requires 6 seconds for only listing query results or 8 seconds for including saving resulting maps in pseudo-colour.
Research on the Mechanism of Public Participation in the Planning and Design of Urban Park Playground
Authors: Yeh Wei-Chieh , Yu-Chien Chen , Lee Huang-Liang , Weng Cheng-Kai 
Published: January 2022

Abstract
Over the recent years, citizens in Taiwan have proposed increasingly stringent demands and standards for urban park playgrounds. Thus, this study aimed to explore and discuss mechanisms for public participation in its planning and design procedures. Furthermore, this study proposed suggestions on mechanisms for public participation in the planning and design process by analyzing public recognition in each of the four phases of public participation. Moreover, questionnaires were distributed to experts and interviews were conducted among park users to gather the appropriate data. The research result showed that participatory design could effectively improve public recognition toward urban park playgrounds and earn confidence among citizens. However, it is noteworthy that the public favors social media communications over traditional forms. On the other hand, the public shows disapproval of a ribbon-cutting ceremony. Finally, the proposed suggestions and recommendations of this study are formulated based on the research findings
Comparison of flavonoid content and antioxidant activity in calyces of two roselle varieties (Hibiscus sabdariffa L.)
Authors: Nerdy N , Barus B R , El-Matury H J , Ginting S , Zebua N F , Bakri T K 
Published: January 2022

Abstract
Free radicals can cause various degenerative diseases such as cancer and cardiovascular disease. Flavonoids have antioxidant abilities that inhibit damage from free radicals. The roselle antioxidant mechanism is associated with high flavonoid content. Red and purple roselles are two varieties of roselle (Hibiscus sabdariffa L.) cultivated in Indonesia. The aim of this research was to analyze the differences in flavonoid content and antioxidant activity in the calyces of two varieties of roselle (Hibiscus sabdariffa L.), red and purple. Total flavonoid analysis and antioxidant activity testing were done by spectrophotometry in the visible region. Total flavonoid content was analyzed by pretreatment with aluminium chloride and sodium acetate. Antioxidant activity was tested with 2,2-diphenyl-1-picrylhydrazyl. The total flavonoids for both red and purple roselle calyces ethanolic extract were 27.55 and 39.18 mg quercetin equivalent per gram. The half maximal inhibitory concentration values obtained for both red and purple roselle calyces ethanolic extract a were 51.59 and 42.17 μg/mL. The total flavonoid content and antioxidant activity of purple roselle calyces ethanolic extract was higher and stronger than red roselle calyces ethanolic extract.
Comparative modal analysis for a twisted beam axle for a hybrid vehicle
Authors: Tomşeanu Laurian , Nicolae Viorel , Vieru Ionel , Marinescu Dănuţ 
Published: January 2022

Abstract
In this article it is presented a comparative analysis of natural mode frequencies for a non-powered rear axle used to fit mass production vehicle and for a similar rear axle derived from the first one to be used to fit a hybrid powered vehicle. The CAD model of the axle and the computed natural mode frequencies were realised using CATIA V5. For calculation, finit element method was used.
Is it possible to turn a diesel engine into a less pollutant device?
Authors: Suciu Cosmin Constantin , Ionel Ioana , Ostoia Daniel , Lontis Nicolae Stelian , Vetres Ion , Igreț Sorin Vlad 
Published: January 2022

Abstract
The current tendency in the eastern part of Europe is to modify old diesel engines with the purpose of improving characteristics in terms of horsepower and torque, but also to reduce the generated pollution. The diesel engines are still in use, against to the tendencies of renouncing to their support, at least in larger urban & industrial areas, where the pollution level, especially the particulate matter (particles PM10, PM2.5) and ozone concentrations, also the NOx are supposed to be generated mostly by diesel engine vehicles. The paper presents results concerning the influence of modifying the diesel engine control unit’s parameters, such as injection quantity, start of injection, intake air pressure and all the others correlated for better performance. The article brings into attention possibilities to reduce the exhaust pollution concentrations, correlated by simultaneous ways of improving the external characteristics of the engine by modifying the engine control unit’s parameters. Measurement results of a compression ignited internal combustion engine before and after the retrofitting, by reparametrization, meaning changing the parameters are presented and discussed.
Fluorescence microscopy-based quantitation of GLUT4 translocation
Authors: Heckmann Mara , Klanert Gerald , Sandner Georg , Lanzerstorfer Peter , Auer Manfred , Weghuber Julian 
Published: January 2022

Abstract
Postprandial insulin-stimulated glucose uptake into target tissue is crucial for the maintenance of normal blood glucose homeostasis. This step is rate-limited by the number of facilitative glucose transporters type 4 (GLUT4) present in the plasma membrane. Since insulin resistance and impaired GLUT4 translocation are associated with the development of metabolic disorders such as type 2 diabetes, this transporter has become an important target of antidiabetic drug research. The application of screening approaches that are based on the analysis of GLUT4 translocation to the plasma membrane to identify substances with insulinomimetic properties has gained global research interest in recent years. Here, we review methods that have been implemented to quantitate the translocation of GLUT4 to the plasma membrane. These methods can be broadly divided into two sections: microscopy-based technologies (e.g., immunoelectron, confocal or total internal reflection fluorescence microscopy) and biochemical and spectrometric approaches (e.g., membrane fractionation, photoaffinity labeling or flow cytometry). In this review, we discuss the most relevant approaches applied to GLUT4 thus far, highlighting the advantages and disadvantages of these approaches, and we provide a critical discussion and outlook into new methodological opportunities.
Experimental and numerical investigation of metal-polymer riveted joints
Authors: Roszak Robert , Bula Karol , Sagradov Ilia , Sterzyński Tomasz , Schob Daniela , Ziegenhorn Matthias 
Published: January 2022

Abstract
This paper presents the modeling and analysis of the joints of metal inserts with polyamide 6 using the injection technique. Based on the experiments carried out, modeling and numerical calculations of the joints were performed for various joint configurations. The metal parts made of DS04 steel have holes. The holes are filled with polyamide 6 (PA6) by injection molding and both components are joined, resulting in a riveted joint. As part of the work, the steel / PA6 riveted joints were tested in a uniaxial tensile test. The main objective was to investigate the strength of the riveted joint as a function of the positioning and the number of rivets. A focus of the work was the numerical modeling of both the material behavior of PA6 and the riveted joint itself. The experiments showed that the polymer-metal joint with less than three rivets is destroyed by shear in the rivets. For a joint consisting of three rivets, the failure was in the rectangular polymer part. For the joint with three rivets, the maximum value of the breaking force was obtained. Similar values were obtained from numerical calculations using Abaqus software.
Understanding the Impact of Equitable Collaborations between Science Institutions and Community-Based Organizations: Improving Science through Community-Led Research
Authors:   The ICBOs and Allies Workgroup, Ricalde María Cecilia Alvarez , Annoni John , Bonney Rick , Bonta J Marcelo , Campbell Patricia B , Castelli Mateo Luna , Cheatom Makeda , Crum Catherine , Valadez Juan Flores , Foli Yao Augustine , González José , Hurtado José Miguel Hernández , Horace Sister Sharon , Kitchen Karen , Fretts Marilú López , Lucey Brigid , Marcos-Iga Pepe , Purcell Karen , Rodriguez Berenice , Schuh Tanya , Turner Phyllis Edwards , Villarreal Fanny , Wilson Bobby 
Published: January 2022

Abstract
To advance justice, equity, diversity, and inclusion in science, we must first understand and improve the dominant-culture frameworks that impede progress and, second, we must intentionally create more equitable models. The present authors call ourselves the ICBOs and Allies Workgroup (ICBOs stands for independent community-based organizations), and we represent communities historically excluded from the sciences. Together with institutional allies and advisors, we began our research because we wanted our voices to be heard, and we hoped to bring a different perspective to doing science with and not on communities. We created a community framework to guide our research and we led all aspects of our work, from creating research protocols to analyzing and interpreting the data to disseminating the results. We share our research framework, methods, and results so that science institutions can better understand how to intentionally create more equitable research partnerships with our communities.
Increased brain volume from higher cereal and lower coffee intake: shared genetic determinants and impacts on cognition and metabolism
Authors: Kang Jujiao , Jia Tianye , Jiao Zeyu , Shen Chun , Xie Chao , Cheng Wei , Sahakian Barbara J , Waxman David , Feng Jianfeng 
Published: January 2022

Abstract
It is unclear how different diets may affect human brain development and if genetic and environmental factors play a part. We investigated diet effects in the UK Biobank data from 18,879 healthy adults and discovered anticorrelated brain-wide gray matter volume (GMV)-association patterns between coffee and cereal intake, coincidence with their anticorrelated genetic constructs. The Mendelian randomization approach further indicated a causal effect of higher coffee intake on reduced total GMV, which is likely through regulating the expression of genes responsible for synaptic development in the brain. The identified genetic factors may further affect people’s lifestyle habits and body/blood fat levels through the mediation of cereal/coffee intake, and the brain-wide expression pattern of gene CPLX3, a dedicated marker of subplate neurons that regulate cortical development and plasticity, may underlie the shared GMV-association patterns among the coffee/cereal intake and cognitive functions. All the main findings were successfully replicated. Our findings thus revealed that high-cereal and low-coffee diets shared similar brain and genetic constructs, leading to long-term beneficial associations regarding cognitive, body mass index (BMI), and other metabolic measures. This study has important implications for public health, especially during the pandemic, given the poorer outcomes of COVID-19 patients with greater BMIs.
Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension
Authors: Fayyaz Ahmed U , Sabbah Michael S , Dasari Surendra , Griffiths Leigh G , DuBrock Hilary M , Wang Ying , Charlesworth M Cristine , Borlaug Barry A , Jenkins Sarah M , Edwards William D , Redfield Margaret M 
Published: January 2022

Abstract

Aims
In heart failure (HF), pulmonary venous hypertension (PVH) produces pulmonary hypertension (PH) with remodeling of pulmonary veins (PV) and arteries (PA). In a porcine PVH model, we performed proteomic-based bioinformatics to investigate unique pathophysiologic mechanisms mediating PA and PV remodeling.

Methods and results
Large PV were banded (PVH, n = 10) or not (Sham, n = 9) in piglets. At sacrifice, PV and PA were perfusion labelled for vessel-specific histology and proteomics. The PA and PV were separately sampled with laser-capture micro-dissection for mass spectrometry. Pulmonary vascular resistance [Wood Units; 8.6 (95% confidence interval: 6.3, 12.3) vs. 2.0 (1.7, 2.3)] and PA [19.9 (standard error of mean, 1.1) vs. 10.3 (1.1)] and PV [14.2 (1.2) vs. 7.6 (1.1)] wall thickness/external diameter (%) were increased in PVH (P &lt; 0.05 for all). Similar numbers of proteins were identified in PA (2093) and PV (2085) with 94% overlap, but biological processes differed. There were more differentially expressed proteins (287 vs. 161), altered canonical pathways (17 vs. 3), and predicted upstream regulators (PUSR; 22 vs. 6) in PV than PA. In PA and PV, bioinformatics indicated activation of the integrated stress response and mammalian target of rapamycin signalling with dysregulated growth. In PV, there was also activation of Rho/Rho-kinase signalling with decreased actin cytoskeletal signalling and altered tight and adherens junctions, ephrin B, and caveolae-mediated endocytosis signalling; all indicating disrupted endothelial barrier function. Indeed, protein biomarkers and the top PUSR in PV (transforming growth factor-beta) suggested endothelial to mesenchymal transition in PV. Findings were similar in human autopsy specimens.

Conclusion
These findings provide new therapeutic targets to oppose pulmonary vascular remodeling in HF-related PH.