bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a predictive model for clinically significant prostate cancer by combining age, PSA density and mpMRI
Authors: Ma Zengni , Wang Xinchao , Zhang Wanchun , Gao Kaisheng , Wang Le , Qian Lixia , Mu Jingjun , Zheng Zhongyi , Cao Xiaoming 
Published: November 2022

Abstract
Purpose
The study aimed to construct a predictive model for clinically significant prostate cancer (csPCa) and to investigate its clinical efficacy to reduce unnecessary prostate biopsies.
Methods
A total of 847 patients from institute 1 were included in Cohort 1 for model development. Cohort 2 included a total of 208 patients from institute 2 for external validation of the model. The data obtained were used for retrospective analysis. The results of magnetic resonance imaging were obtained using Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v2.1). Univariate and multivariate analyses were performed to determine significant predictors of csPCa. The diagnostic performances were compared using the receiver operating characteristic (ROC) curve analysis and decision curve analyses.
Results
Age, prostate-specific antigen density (PSAD) and PI-RADS v2.1 scores were used as predictors of the model. In the development cohort, the areas under the ROC curve (AUC) for csPCa about age, PSAD, PI-RADS v2.1 scores, and the model were 0.675, 0.823, 0.875, and 0.938, respectively. In the external validation cohort, the AUC values predicted by the four were 0.619, 0.811, 0.863, and 0.914, respectively. Decision curve analysis revealed that the clear net benefit of the model was higher than PI-RADS v2.1 scores and PSAD. The model significantly reduced unnecessary prostate biopsies within the risk threshold greater than 10%.
Conclusions
In both internal and external validation, the model constructed by combining age, PSAD, and PI-RADS v2.1 scores exhibited excellent clinical efficacy and can be utilized to reduce unnecessary prostate biopsies.
Arbitrator Miniature: A Paradigm using Data Science Methods to Predict Academic Performance
Authors: Malik Saleem , k jothimani 
Published: November 2022

Abstract
Informational tools are necessary at schools and colleges due to the sheer volume and diversity of data they handle. Numerous scholars has emphasized towards applying machine learning to retrieve information from the education database to enable students and educators in attaining greater results as a means of simplifying essential work. Selecting efficient tactics that might produce acceptable prediction performance is a challenging task for prediction models. In order to improve classification performance by addressing the misclassification issue, this study proposes a hybrid approach known as arbitrator miniature that combines factor analysis with the following nine machine learning techniques: Support vector machine, Random Forest, K Nearest Neighbor, Logistic Regression, Artificial neural network, Decision Tree, XG boost, Ada boost and Naïve Bayes. To evaluate the robustness of the suggested models, student datasets from a variety of academic fields at diploma-granting institutions in Karnataka, India, were used. In order to assess the proposed model using the datasets, assessment criteria such as classification accuracy and root mean square error were employed. This study’s findings revealed that proposed arbitrator miniature model might significantly improve classification performance. For the purpose of resolving prediction and classification issues, the proposed arbitrator miniature may be viewed as the best prediction models.
Outcomes of transplant-eligible patients with myelodysplastic syndrome with excess blasts registered in a prospective observational study: The JALSG-CS11-MDS-SCT
Authors: Ishiyama Ken , Nakagawa Noriharu , Usuki Kensuke , Takada Satoru , Tomikawa Tatsuki , Handa Hiroshi , Katsuoka Yuna , Hirano Daiki , Sezaki Nobuo , Sumi Masahiko , Fujisawa Shin , Taniguchi Yasuhiro , Mugitani Atsuko , Yoshimura Takuro , Ohtsuka Eiichi , Takase Ken , Suehiro Youko , Ota Shuichi , Kajiguchi Tomohiro , Maeda Tomoya , Yamamoto Masahide , Ohtake Shigeki , Katsumi Akira , Kiyoi Hitoshi , Matsumura Itaru , Miyazaki Yasushi 
Published: November 2022

Abstract
Allogeneic hematopoietic stem cell transplantation (allo-SCT) is the sole curative therapy for myelodysplastic syndromes (MDS). However, whether bridging therapy (BRT) including azacitidine (AZA) and combination chemotherapy (CCT) prior to allo-SCT should be performed is unclear. We analyzed BRT and the outcomes of patients with myelodysplastic syndrome with excess blasts (MDS-EB) who were registered in a prospective observational study in order to clarify the optimal allo-SCT strategy for high-risk MDS. A total of 371 patients were included in this study. Among 188 patients (50.7%) who were considered for allo-SCT, 141 actually underwent allo-SCT. Among the patients who underwent allo-SCT, 64 received AZA, 29 received CCT and 26 underwent allo-SCT without BRT as an initial treatment. The multivariate analysis identified BRT as independent factors influencing overall survival (AZA vs. without BRT, hazard ratio [HR] 3.33, 95% confidence interval [95%CI] 1.44–7.70, P = 0.005; CCT vs. without BRT, HR 3.82, 95%CI 1.60–9.14, P = 0.003). In a multivariate analysis, BRT showed an independent association with progression-free survival (AZA vs. without BRT, HR 2.23, 95%CI 1.03–4.83, P = 0.041; CCT vs. without BRT, HR 2.94, 95%CI 1.29–6.69, P = 0.010). Transplant-eligible patients with MDS-EB should undergo upfront allo-SCT without BRT.
Mineral identification of human kidney stones in South Brazil.
Authors: DIAS ISIS ARMSTRONG , CARVALHO MAURICIO , BAHNIUK ANELIZE , FROEHNER SANDRO , REIS JOSE MANOEL DOS 
Published: November 2022

Abstract
Kidney stones are precipitated when abnormal conditions within the urinary tract promotes local ions supersaturation, changes in the pH, and, in some cases, a differential bacterial influence. The most common minerals in kidney stones are calcium oxalates, followed by calcium phosphates, struvite, cystine and uric acid. In this study, the morphological and mineralogical characteristics of kidney stones were registered and applied to simplify their identification and facilitate the diagnosis. Furthermore, we performed isotopic analysis to verify the likelihood of external factors influencing kidney stones formation. In total, 160 samples of kidney stones from different patients above 18 years old were analyzed. We examined the morphological characterization macroscopically, based on features such as color, fabric and relative hardness. The x-ray diffraction (XRD) applied to mineral identification indicated that whewellite was present in 64% of the samples, followed by 14% uric acid stones and 10% struvite stones. The x-ray fluorescence (XRF) revealed that the majority of the kidney stones were formed by phosphates and calcium oxides, followed by magnesium, sodium and sulfur oxides. Isotopic analysis showed δ13C values from − 23 to -8‰ and δ18O values between − 12 and − 6‰ in different types of kidney stones. All the results have shown that it is possible to improve the discrimination of kidney stones based on some morphological features associated with chemical and isotopic composition. Furthermore, isotopic results have suggested that kidney stone formation can be associated with different diets and water intake.
Diabetic striatopathy in the elderly: Clinical and radiological manifestations
Authors: Fang Wenli 
Published: November 2022

Abstract
Diabetic striatopathy (DS) can be a reversible emergency with a good prognosis when diagnosed and treated timely. However, patients with diabetic striatopathy are easily misdiagnosed mainly due to its rarity and most physicians’ unfamiliarity. Therefore, we conducted this study to reveal the clinical-radiographic features of diabetic striatopathy and advance our knowledge of this rare but important condition. We retrospectively reviewed and analyzed the clinical data of patients with diabetic striatopathy in our hospital between January 2013 and July 2022. Four cases were finally included, and the mean age of the identified patients was (63 ± 9) years. We found that the majority (75%) of patients were newly diagnosed as having type 2 diabetes mellitus and the average levels of blood glucose and hemoglobin A1C were 275 mg/dL and 13.0%, respectively. One patient was positive for ketone bodies. All the patients were presented with continuous and involuntary motion of their extremities. The most commonly involved body regions were lateral arm-leg. The commonly involved concomitant regions on CT and MRI were putamen and globus pallidus. Three of the four cases achieved substantial recovery with glucose-control treatments and anti-chorea medications within 10 days. Our finding suggests that it is of great importance to be aware of diabetic striatopathy when across with patients suffering from acute onset of hemi-chorea even though they have not a prior history of diabetes.
Oblateness and mass variation effects on the Hill R4BP
Authors: Ansari Abdullah A. , Sahdev S. K. , Alebraheem Jawdat 
Published: November 2022

Abstract
The oblateness and mass variation effects are studied in the circular Hill restricted 4-body problem (R4BP). Here we assume two bodies as oblate in shape and third one as spherical in shape, these three bodies are at the vertices of a triangle. The 4th infinitesimal body varies its mass and moving under the perturbed gravitational forces in the plane of primaries. With these perturbations, we evaluate the equations of motion and quasi-jacobian integral using specific scales and transformations. Finally, the numerical presentations are given such as stationary points, regions of motion, surfaces of section, periodic orbits and basins of convergence.
Comparison of navigation-assisted single position oblique lumbar interbody fusion and minimally invasive surgical transforaminal lumbar interbody fusion in L4 degenerative lumbar spondylolisthesis: A retrospective analysis
Authors: Wen Haohui , Wang Min , Yang Dazhi , Yi Weihong 
Published: November 2022

Abstract
Background: Minimally invasive surgical oblique lumbar interbody fusion (MIS-OLIF) is an innovative anterolateral, retroperitoneal, and anterior psoas approach for L4 degenerative lumbar spondylolisthesis (DLS). A single-position technique and the utilize of the navigation system improves surgical outcomes.
Methods: This study retrospectively analyzed successive patients treated with navigation-assisted single position oblique lumbar interbody fusion (NASP-OLIF) or minimally invasive surgical transforaminal lumbar interbody fusion (MIS-TLIF) for L4 DLS. According to the surgical procedures, participants were divided into NASP-OLIF and MIS-TLIF groups. Operative duration times, intraoperative blood loss, postoperative first floor activity time, total screw placement time, per screw time, cage height, visual analog scale (VAS), Oswestry disability index (ODI), slipping distance (SD), segmental lordosis (SL), intervertebral foraminal area (IFA), intervertebral disc height (IDH), and spinal canal cross-sectional area(CSA) were compared between groups.
Results: Among 53 patients (NASP-OLIF: 25 vs MIS-TLIF: 28) treated for L4 DLS between September 2017 and June 2020. There were 212 pedicle screws insertion (NASP-OLIF: 100 vs MIS-TLIF: 112). In the NASP-OLIF group, according to the Gertzbein-Robbins scale, screws were as follow: grade A with 90 screws, grade B with 6 screws, grade C with 3 screws, grade D with 1 screw, Grade E with no screw.There were no neurovascular injury. The satisfactory rate of screw insertion was 96%. The NASP-OLIF group showed significantly shorter the operative duration times, lessened intraoperative blood loss, higher cage height and shorter postoperative first floor activity time, and shorter total screw and per-screw placement times (P<0.05). On postoperative and last follow-ups,IDH and IFA were significantly improved in the NASP-OLIF group (P<0.05); VAS of leg pain (VASL), VAS of low back pain (VASB), and ODI were significantly decreased in the NASP-OLIF group (P<0.05). SL, SD, or CSA was no remarkably differences between groups (P>0.05).
Conclusions: NASP-OLIF was superior to MIS-TLIF in the aspect of the reduction of trauma and faster recovery. However, the two surgical techniques were comparable in many other aspects.
Magnetic and Resistivity Imaging of a probable Fault within the Precambrian Crystalline Rocks in Ogbomoso, Southwestern Nigeria
Authors: Bayowa Oyelowo Gabriel , Fawole Olamide , Olorunfemi Martins Olusola , Ajagbe Sordiq Obafemi , Oni Ademakinwa George , Adelere Isaiah Oluwadara , Ajibade Monsur Olawale , Ajibola Febisola Esther 
Published: November 2022

Abstract
A linear geological structure which is suspected to be a fault within the Precambrian Basement Complex rocks of Ogbomoso, Southwestern Nigeria is found in the geological map of Ogbomoso Southwest Sheet 222. The ground magnetic and electrical resistivity methods were used to investigate the structure and determine its physical characteristics. Five (5) traverses with lengths varying from 700–800 m and trending NNW-SSE (N338oW) were established perpendicularly (ENE-WSW, N68oE) to the suspected fault. Total magnetic field data were acquired at 10 m interval, corrected for diurnal variation and inverted using the Geosoft Oasis Montaj software package. Dipole-Dipole resistivity data were acquired on the traverses using a dipole length of 20 m with expansion factor n varying from 1 to 5 and modelled to generate 2D resistivity structures with the DIPPRO™ software package. Thirty-seven (37) depth sounding data were acquired, quantitatively interpreted and the results used to generate geoelectric sections along the suspected geologic features. Three (3) parallel linear features F1-F1, F2-F2 and F3-F3 characterized by peak negative (-110 to -20 nT) magnetic anomalies typical of thin and thick dykes (in low magnetic latitude) and low resistivity vertical discontinuities (˃ 188 m deep, 30–153 m wide) within 2D resistivity structures, were identified across the five traverses. F1-F1 coincided with the suspected fault, F1-F1. F2-F2 and F3-F3 are parallel and suspected to be syngenetic with F1-F1. The absence of a significant vertical displacement, typical of normal faulting, in the basement bedrock on the 2D geoelectric sections corroborated the inference of strike slip faulting from the geological map.
A Potential Predictive Marker for Advanced Hepatocellular Carcinoma PD-1 Inhibitors Combined with Radiation: Expression of PD-L1 on Circulating Tumor Cells
Authors: Chen Jiali , Wu Zhenying , He Kun , Guo Lu , Rao Mingyue , Zhang Jianwen , Li Han , Su Ke , Xu Ke , Gu Tao , Wang Pan , Zeng Hao , Hu Lanxin , Han Yunwei 
Published: November 2022

Abstract
Purpose
In the treatment of advanced hepatocellular carcinoma (HCC), programmed death-1 (PD-1) immune checkpoint inhibitors has recently been shown to be highly effective when combined with radiotherapy. Furthermore, they have become the hotspot in cancer diagnosis and treatment for the detection of programmed death-ligand 1 (PD-L1) in circulating tumor cells (CTCs). However, their predictive effect is not well established. Therefore, this study examined whether PD-L1 expression in CTCs can be used as a marker to predict treatment response in patients with advanced HCC.
Methods
Patients treated with both PD-1 inhibitors and intensity-modulated radiation therapy (IMRT) were enrolled in the study. After radiation therapy, PD-1 inhibitor treatment was administered every 3 weeks until disease progression. Peripheral blood (2 mL) was collected from patients before and after treatment, and CTC PD-L1 was detected using the Watson Biotechnology reagent (China).
Results
A total of 28 patients with HCC were enrolled in this study. The disease control rate (DCR) was significantly higher in patients with PD-L1(+) CTC enrichment at baseline than in controls (92.3% and 50%, respectively). Before treatment, patients with PD-L1(+) CTCs ≥ 2 had a higher median progression-free survival (mPFS) than those with PD-L1(+) CTCs ≤ 1 (3.50 vs. 3.35 months). After treatment, CTCs with PD-L1(+) ≤ 1 were significantly associated with longer mPFS than CTCs with PD-L1(+) ≥ 2 (4.20 vs. 1.90 months, P < 0.01).
Conclusions
The presence of CTCs expressing PD-L1(+) might predict efficacy and prognosis in HCC patients treated with PD-1 inhibitors and radiotherapy.
Retrospectively registered
The study has been registered with the Chinese Clinical Trials Registry (registration number: ChiCTR2100044198).
Glycogen synthase kinase-3 inhibitors suppress morphine-induced Straub’s tail via a centrally acting mechanism
Authors: Kitanaka Junichi , Kitanaka Nobue , Tomita Kazuo , Hall F. Scott , Igarashi Kento , Uhl George R. , Sato Tomoaki 
Published: November 2022

Abstract
We investigated morphine-induced Straub’s tail reaction (STR) in mice pretreated with or without glycogen synthase kinase-3 (GSK-3) inhibitors (SB216763 and AR-A014418) by using a newly modified, infrared beam sensor-based automated apparatus. Mice treated with a single injection of morphine (30 mg/kg, i.p.) showed a significant STR with a plateau level at a time point of 20 min after morphine challenge. Pretreatment of mice with SB216763 (5 mg/kg, s.c.) or AR-A014418 (3 mg/kg, i.p.) significantly inhibited morphine-induced STR and attenuated the duration of STR in a dose-dependent fashion. In the striatum and the nucleus accumbens, expression of pGSK-3βTyr216 but not GSK3β or pGSK-3βSer9 was slightly reduced after treatment with SB216763 (5 mg/kg, s.c.) in combination with/without morphine, indicating that the inhibitory effect of GSK-3 inhibitors on morphine-induced STR and hyperlocomotion might not depend on the direct blockade of GSK-3β function. In constipated mice after morphine challenge (30 mg/kg), the effect of GSK-3 inhibitors on gastrointestinal transit was examined to reveal whether the action of GSK-3 inhibitors on morphine effects was central and/or peripheral. Pretreatment with SB216763 (5 mg/kg) did not improve constipation in morphine-injected mice. The mechanism of action seems to be central but not peripheral, although the underlying subcellular mechanism of GSK-3 inhibitors is not clear. Our measurement system is a useful tool for investigating the excitatory effects of morphine in experimental animals.
Geniposide Augments Apoptosis in Fibroblast-like Synoviocytes by restoring Hypoxia-enhanced JNK-BNIP3-mediated Autophagy
Authors: Deng Ran , Wang Yan , Bu Yanhong , Wu Hong 
Published: November 2022

Abstract
Objective
As the main effector cells of chronic inflammation and hyperplasia of synovium, fibroblast-like synoviocytes (FLSs) show abnormal proliferation and insufficient apoptosis in hypoxic microenvironment, which is due to the increase of BNIP3-mediated autophagy. This study aimed to explore the mechanism of geniposide (GE) on hypoxia-induced hyper-proliferative FLSs with a focus on autophagy and JNK-BNIP3 pathway.
Materials and methods
The dynamic changes of autophagy and apoptosis and the expression of hypoxia related proteins in adjuvant arthritis (AA) rats were detected by immunohistochemistry and Western blot. The proliferation, autophagy, apoptosis and mitochondrial state of FLSs were detected by CCK-8, flow cytometry, immunofluorescence and transmission electron microscopy, respectively.
Results
The excessive accumulation of BNIP3 in synovium of AA rats was accompanied by inhibition of apoptosis and increase of autophagy. GE inhibited the expression of BNIP3, enhanced apoptosis and decreased autophagy, and improved chronic inflammation and hyperplasia of synovium. The amount of autophagy under different oxygen concentrations was the key to mediate the different survival rates of FLSs, and the inhibition of autophagy triggered apoptosis. GE suppresssed the proliferation of FLSs, and down-regulated autophagy, leading to the accumulation of ROS and the decrease of mitochondrial membrane potential (MMP), induced the increase of apoptosis, and suppressed the accumulation of BNIP3 and the hyperphosphorylation of JNK.
Conclusions
GE inhibited autophagy by restoring the hypoxia-induced activated JNK-BNIP3 pathway, inducing mitochondrial oxidative damage, augmented apoptosis and decreased survival rate of FLSs.
Microsurgical anatomy of the anterior cerebral artery and the arterial supply of the cingulate gyrus
Authors: Guner Yahya Efe , Comert Ayhan , Sayaci Emre Yagiz , Korkmaz Ali Can , Gungor Yigit , Guler Tugba Morali , Kahilogullari Gokmen , Savas Ali 
Published: November 2022

Abstract
Purpose: The cingulate gyrus is a potential surgical area to treat tumours, psychiatric diseases, intractable pain and vascular malformations. The aim of the study was to define the topographic anatomy and arterial supply of the cingulate gyrus located on the medial surface of the cerebral hemisphere.
Methods: We studied thirty-six hemispheres, each hemisected in the midsagittal plane. The vertical thickness of the cingulate gyrus was measured at the anterior commissure (AC), posterior commissure (PC), and genu levels of the corpus callosum. The branches of the anterior and posterior cerebral arteries supplying each zone were noted separately. The arterial pathways were transformed to digital data in AutoCAD to identify the condensation and reduction areas.
Results: The mean AC-PC distance was 27.17±1.63 mm. The thinnest region was the genu level of the corpus callosum (10.29 mm). The superior internal parietal artery (SIPA), inferior internal parietal artery (IIPA) and pericallosal artery (PrCA) supplied all zones of the cingulate gyrus. The anterior zone received the greatest supply. The arterial condensation and reduction areas on both sides of cingulate gyrus and its x, y, and z coordinates specified.
Conclusions The target cingulotomy (TC) area was determined for anterior cingulotomy. The properties of the TC area are that the thinnest region of the cingulate gyrus is supplied relatively less than other areas and is close to the anterior cingulotomy areas in the literature. The arterial reduction area (ARA) was found to be suitable for corpus callosotomy in terms of avoiding haemorrhage.
Impact of Mhd on Couple Stress Fluid Flow Enclosing a Solid Sphere in a Porous Medium
Authors: Deo Satya , Maurya Pankaj Kumar , Maurya Deepak Kumar 
Published: November 2022

Abstract
This work concerns the Stokesian flow of an axisymmetric, incompressible couple stress fluid through a porous medium which encloses a solid sphere, under a uniform magnetic field. The problem is solved analytically by using separation of variables technique and expressions for stream function, velocity components, vorticity component, fluid pressure, stress tensors and couple stresses are obtained in terms of modified Bessel functions. A new result for drag force experienced by a solid sphere enclosed in porous medium under the applied uniform magnetic field is evaluated. Some special cases for flow past the impermeable sphere are obtained and validated by the existing results. Also, a well-known result of drag force for the Stokes flow past an impermeable sphere is reported. The profiles of tangential velocity, drag force and patterns of streamlines are plotted for different values of flow parameters.