bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance on Adverse Events Following COVISHIELD (ChAdOx1
nCoV-19) vaccination in Goa, India: An Observational Study
Authors: Jose Dhanya , Dhupdale Nitin , Cacodcar Jagadish A. , Kamat Umesh 
Published: August 2022

Background:
COVISHIELD, ChAdOx1 nCoV- 19 Corona Virus Vaccine was granted
emergency use authorization (EUA) as the first vaccine in India in January 2021. Knowing what to
anticipate after vaccination will reduce vaccine hesitancy in the public. This study aimed to identify
and measure the adverse events following COVID-19 vaccination.

Materials and Methods:
A cross-sectional observational study was conducted at Goa Medical College,
starting on February 21 till May 23, 2021. A total of 418 people were enrolled. We collected
the data using the Microsoft Form and analyzed using Microsoft Excel and R-program.

Results:
Of the 418 vaccine recipients, the incidence rate of AEFI (Adverse Events Following Immunization)
was 54.31%. Fever, fatigue, and headache were the most commonly reported systemic
AEFIs. Among these, 54.7% of AEFI were mild, 42.38% were of the moderate category, and only
2.96% were of grade 3 severity. None of the AEFIs were severe enough for hospitalization. Most
of them developed symptoms within 24 hours of the first dose. Complete recovery from AEFIs
took a median time of 24 hours.

Conclusion:
Most of our study findings were consistent with the phase 1, 2/3 trials findings of
Oxford-AstraZeneca's ChAdOx1 vaccine. The AEFI symptoms were considered immune reactions
to the vaccine. The AEFIs were more common among younger individuals and females. The
chance of missing a serious adverse event like a thromboembolic phenomenon cannot be ruled out.
We observed low AEFI rates with COVISHIELD in the Indian population compared to Oxford-
AstraZeneca's ChAdOx1 vaccine in the UK-based population, which can be explained by preexisting
immunity against adenovirus in the Indian population. However, based on the study findings,
we may interpret that the COVISHIELD, Serum Institute of India, carries a good safety profile
overall.
LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus
Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects
the Progression of Intervertebral Disc Degeneration
Authors: Xu Shimin , Li Yuezhong , Zhang Junshan , Li Zhiwei 
Published: August 2022

Objective::
Intervertebral disc degeneration (IDD) represents one of the leading causes of low
back pain. Research suggests the participation of LINC01116 in IDD progression. Herein, the current
study explored the underlying mechanism of LINC01116 in IDD.

Methods::
The differential expression patterns of LINC01116 in IDD and normal tissues were analyzed
using the GEO database. Human nucleus pulposus (NP) cells were provided and treated with IL-1β to
establish IDD models in vitro. LINC01116 expression was detected and intervened. Indices such as cell
proliferation, apoptosis, and extracellular matrix (ECM)-related factor expression were determined using
CCK-8 assay, flow cytometry, and Western blotting. LINC01116 sublocation was identified by means of
nuclear/cytosol fractionation assay. The binding relationships between LINC01116 and miR-9-5p and
miR-9-5p and ZIC5 were verified by bioinformatics analysis, dual-luciferase assays, RNA immunoprecipitation
(RIP) assay, and RNA-pull-down. Western blotting was conducted to measure the levels of the
Wnt pathway key factors.

Results and Discussion::
LINC01116 was highly expressed in the degenerative NP cells. Silencing of
LINC01116 critically promoted degenerative NP cell proliferation and inhibited apoptosis and ECM loss.
LINC01116 was located in the cytoplasm. In degenerative NP cell models, LINC01116 could competitively
bind to miR-9-5p to elevate ZIC5 expression. LINC01116 induced NP cell apoptosis and impeded
NP cell proliferation and ECM synthesis by inhibiting miR-9-5p and miR-9-5p targeted ZIC5. ZIC5 could
effectively increase the levels of the Wnt pathway-related factors.

Conclusion::
Silencing LINC01116 blocked its adsorption of miR-9-5p as a sponge to promote the miR-9-
5p expression and inhibit ZIC5/Wnt activation, thus impacting NP cell biological functions
Insight into the Tubulin-Targeted Anticancer Potential of Noscapine and its Structural
Analogs
Authors: Shukla Shefali , Kumar Sanjay , Sagar Bulbul , Gaur Abhay , Pandey Ekta , Gulati Shikha 
Published: August 2022

Abstract:
Cancer is known as a notorious disease responsible for threatening millions of lives every year. Natural
products which act by disrupting the microtubule assembly and dynamics have proven to be highly successful as anticancer
agents but their high toxicity owing to lower selectivity has limited their usage. Recently, Noscapine (NOS), a
known anti-tussive, has come out to be an effective anti-tubulin candidate with far lesser toxicity. Since its first report
as an anti-mitotic agent in 1998, NOS has been extensively studied and modified by various groups of researchers to
optimize its anti-tubulin activity. In this review, the recent advancements about the potential of these therapeutic candidates
against various cancers have been compiled and analyzed for their inhibitory mechanism in distinct health conditions.
It has been observed that the non-polar substitutions (e.g., halides, aryl groups) at specific sites (9-position and
N-sites of isoquinoline ring; and modification of a methoxy group) have an enhanced effect on efficacy. The mechanistic
studies of NOS and its modified analogs have shown their inhibitory action primarily through interaction with microtubules
dynamics thus disrupting the cell-cycle and leading to apoptosis. This review highlights the latest research
in the field by providing a rich resource for the researchers to have a hands-on analysis of NOS analogs and the inhibitory
action in comparison to other microtubule disrupting anti-cancer agents. The article also documents the newer
investigations in studying the potential of noscapine analogs as possible anti-microbial and antiviral agents.
Synthesis of Si/SiO2 core/shell fluorescent submicron-spheres for monitoring the accumulation of colloidal silica during the growth of diatom Chaetoceros sp.
Authors: Quynh Luu Manh , Huy Hoang Van , Thien Nguyen Duy , Van Le Thi Cam , Dung Le Viet 
Published: August 2022

Marine diatoms play a very crucial role in carbon export, and current food-web and become an important factor in global silica cycle. This then has made the mechanism of their biosilicification interesting to be a research subject. The classical theory states that the silica metabolism has been originated from the absorption of silicate ions, which might not give a suitable explanation for the solid silica silicification. In this study, mono-disperse Si/SiO2 fluorescent submicron-spheres were synthesized in aqueous solution, and applied in monitoring the extracellular solid silica accumulation of Chaetoceros sp. diatom. The Si/SiO2 submicron particles emitted light-blue color with the spectrum centered at 440 nm under the excitation of 365 nm UV light, similar to the typical excitation/emission pair of the DAPI fluorophore (excitation/emission: 358 nm/461 nm). The fluorescence-microscopic investigation showed that the Si/SiO2 particles delocalized on the diatoms’ surface and increased a silicic-acid-level surrounding the microalgae. As a consequence, the growth rate of the diatoms increased as the concentration of the SiO2 particles was at 120 mg/L, and reached 1.5 times higher than the growth rate calculated from the F2 media. The study not only introduces a new aspect to the extracellular metabolism of microalgae biosilicification corresponding to the global silica cycle, but also presents a new-type of culturing media using SiO2 nanoparticles for diatom cultivation, which increases the growth rate of artificial diatom-culturing for further applications.
Analisis Perencanaan Dan Pengawasan Persediaan Minyak Kelapa Sawit Pada PT. Pacific Palmindo Industri Medan
Authors: Anggraini Ratih , Sari Purwita , Aisyah Siti , Adhiko Ridho Gilang , Fadillah Tri Dessy , Awalia Kiki 
Published: August 2022

<div id="gtx-trans" style="position: absolute; left: -7px; top: -20px;"><em>Pengendalian persediaan meliputi pengendalian fisik dan pengendalian akuntansi. Pengendalian material terutama ditujukan pada sarana penyimpanan persediaan di gudang dan pengendalian jumlah yang dibutuhkan. Sedangkan pengawasan akuntansi terkait dengan sistem pengendalian internal perusahaan. Pengendalian persediaan harus dapat memberikan informasi yang akurat kepada manajemen sehingga dapat membantu manajemen dalam proses pengambilan keputusan. Masalahnya adalah apakah teknik pengendalian persediaan cukup efektif dan efisien untuk bisnis. Data sekunder yang diperoleh dari bisnis mencakup sejarah singkat bisnis, struktur organisasinya, dan laporan inventarisnya. Jenis penelitian yang penulis pakai dalam penelitian ini yaitu pendekatan kuantitatif.Metode analisis data dalam penelitian ini adalah deskriptif. Hasil penelitian menunjukkan bahwa pelacakan persediaan minyak sawit oleh perusahaan menggunakan teknik pengendalian persediaan, baik pengendalian persediaan fisik maupun pengendalian mutu, telah diterapkan sepenuhnya. Sistem akuntansi persediaan cukup baik dalam upayanya melindungi persediaan dari penipuan dan meningkatkan keandalan dan keakuratan pencatatan akuntansi persediaan. Adanya pemisahan tugas dan tanggung jawab, sistem otorisasi yang memadai, dan pemeriksaan operasional yang independen menunjukkan bahwa perusahaan memiliki prosedur pengendalian persediaan yang benar. </em> </div>
Pengaruh Kompensasi Terhadap Kinerja Karyawan Pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara
Authors: Dewi Ananda Fitriani 
Published: August 2022

<em>Tujuan penelitian adalah untuk mengetahui Pengaruh Kompensasi Terhadap Kinerja Karyawan pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara, dan manfaatnya sebagai bahan masukan dan informasi bagi perusahaan untuk merumuskan kebijakan pemasaran, sebagai bahan kajian ilmiah dari teori yang pernah didapat untuk bisa diimplementasikan secara empiris dilapangan, sebagai bahan referensi bagi penelitian selanjutnya.Data dalam penelitian diambil melalui kuesioner dengan teknik pengumpulan data menggunakan metode observasi dan studi dokumentasi. Sedangkan teknik analisis data menggunakan analisis korelasi.Hasil penelitian ini memperlihatkan bahwa pengaruh bersifat positif atau searah berarti jika kompensasi meningkat maka kinerja karyawan juga akan meningkat. Sedangkan signifikan atau nyata berarti kompensasi memang benar-benar penentu atau prediktor dari kinerja karyawan PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara. Sehingga dapat dikatakan bahwa semakin tinggi kompensasi maka kinerja karyawan juga akan meningkat. Demikian sebaliknya semakin rendah kompensasi semakin rendah kinerja karyawan yang dicapai perusahaan. Selanjutnya dapat dilihat bahwa kontribusi kompensasi terhadap kinerja karyawan PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara sebesar 42,0%, uji t (uji hipotesis) sebesar 2,80 menunjukkan bahwa adanya pengaruh positif dan signifikan antara kinerja karyawan pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara dengan nilai 2,80 (2,80 &gt; 1,696). Hasil koefisien determinan adalah 17,6% memiliki makna bahwa variabel kompensasi tidak memiliki hubungan yang erat terhadap kinerja karyawan pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara.</em>
Health Beliefs Associated with Metformin Use Among Insured Adults with Prediabetes
Authors: McEwen Laura N. , Hurst Thomas E. , Joiner Kevin L. , Herman William H. 
Published: August 2022

<p> </p>
<p><strong>Objective</strong>: To use the framework of the Health Belief Model (HBM) to explore factors associated with metformin use among adults with prediabetes.</p>
<p><strong>Research Design and Methods</strong>: We analyzed survey data from 200 metformin users and 1,277 non-metformin users with prediabetes identified from a large, insured workforce. All subjects were offered the National Diabetes Prevention Program (DPP) at no out-of-pocket cost. We constructed bivariate and multivariate models to investigate how perceived threat, perceived benefits, self-efficacy, and cues to action impacted metformin use and how demographic, clinical, sociopsychological, and structural variables impacted the associations.</p>
<p><strong>Results</strong>: Adults with prediabetes who used metformin were younger, more likely to be women, and to have worse self-rated health and higher BMIs than those with prediabetes who did not use metformin. Those who used metformin were also more likely to be aware of their prediabetes and to have a personal history of gestational diabetes or a family history of diabetes. After considering perceived threat, perceived benefits, self-efficacy, and cues to action, the only independent predictors of metformin use were younger age, female sex, higher BMI, and cues to action, most specifically, a doctor offering metformin therapy. </p>
<p><strong>Conclusions</strong>: Demographic and clinical factors and cues to action impact the likelihood of metformin use for diabetes prevention. Perceived threat, perceived benefits, and self-efficacy were not independently associated with metformin use. These results highlight the importance of patient-centered primary care and shared decision making in diabetes prevention. Clinicians should proactively offer metformin to patients with prediabetes to facilitate effective diabetes prevention. </p>
<p><br></p>
Evolution of Clinical Complexity, Treatment Burden, Healthcare Utilization, and Diabetes-Related Outcomes among Commercial and Medicare Advantage Beneficiaries with Diabetes in the U.S., 2006-2018
Authors: Benning Tyler J. , Heien Herbert C. , McCoy Rozalina G. 
Published: August 2022

<p> </p>
<p><strong>Objective:</strong> To characterize trends in clinical complexity, treatment burden, healthcare utilization, and diabetes-related outcomes among adults with diabetes.</p>
<p><strong>Research Design and Methods: </strong>A nationwide claims database was used to identify enrollees in commercial and Medicare Advantage plans who met claims criteria for diabetes between 01/01/2006 and 03/31/2019 and to quantify annual trends in clinical complexity (e.g., active health conditions), treatment burden (e.g., medications), healthcare utilization (e.g., ambulatory, emergency department [ED], and hospital visits), and diabetes-related outcomes (e.g., hemoglobin A1c [HbA1c] levels) between 2006 and 2018. </p>
<p><strong>Results: </strong>Among 1,470,799 commercially-insured patients, the proportion with ≥10 active health conditions increased from 33.3% (95% CI 33.1%-33.4%) in 2006 to 38.9% (38.8%-39.1%) in 2018 (p=0.001), and the proportion taking ≥3 glucose-lowering medications increased from 11.6% (11.5%-11.7%) to 23.1% (22.9%-23.2%), (p=0.007). The proportion with HbA1c ≥8.0% (≥64 mmol/mol) increased from 28.0% (27.7%-28.3%) in 2006 to 30.5% (30.2%-30.7%) in 2015, decreasing to 27.8% (27.5%-28.0%) in 2018 (overall trend p=0.04). Number of ambulatory visits per patient/year decreased from 6.86 (6.84-6.88) to 6.19 (6.17-6.21), (p=0.001), while ED visits increased from 0.26 (0.257-0.263) to 0.29 (0.287-0.293), (p=0.001). Among 1,311,903 Medicare Advantage enrollees, the proportion with ≥10 active conditions increased from 51.6% (51.2%-52.0%) to 65.1% (65.0%-65.2%), (p<0.001), the proportion taking ≥3 glucose-lowering medications was stable at 16.6% (16.3%-16.9%) and 18.1% (18.0%-18.2%), (p=0.98), and the proportion with HbA1c ≥8.0% increased from 17.4% (16.7%-18.1%) to 18.6% (18.4%-18.7%), (p=0.008). Ambulatory visits per patient per year remained stable at 8.01 (7.96-8.06) and 8.17 (8.16-9.19), (p=0.23), but ED visits increased from 0.41 (0.40-0.42) to 0.66 (0.66-0.66), (p<0.001).</p>
<p><strong>Conclusions: </strong>Patients with diabetes are becoming increasingly complex over time, have higher treatment burden, and experience more ED visits for potentially low acuity conditions.</p>
Plasma exosomal microRNAs associated with metabolism as early predictor of gestational diabetes mellitus
Authors: Ye Zhixin , Wang Songzi , Huang Xiaoqing , Chen Peisong , Deng Langhui , Li Shiqi , Lin Suiwen , Wang Zilian , Liu Bin 
Published: August 2022

<p>To date, the microRNA (miRNA) expression profile of plasma exosomes in women whose pregnancy is complicated by gestational diabetes mellitus (GDM) has not been fully clarified. In this study, differentially expressed miRNAs in plasma exosomes were identified by high-throughput small RNA sequencing in 12 GDM and 12 normal glucose tolerance (NGT) pregnant women and validated in 102 GDM and 101 NGT pregnant women. A total of 22 exosomal miRNAs were found and five of them were verified by qRT-PCR. Exosmal miR-423-5p was upregulated, while miR-122-5p, miR-148a-3p, miR-192-5p, and miR-99a-5p were downregulated in women whose pregnancy is complicated by GDM. IGF1R and GYS1 as target genes of miR-423-5p, and G6PC3 and FDFT1 as target genes of miR-122-5p, were associated with insulin and AMPK signaling pathways and may participate in the regulation of metabolism in GDM. The five exosomal miRNAs showed an AUC of 0.82 (95%CI, 0.73~0.91) in early prediction of GDM. Our study demonstrated that dysregulated exosomal miRNAs in plasma from GDM pregnant women might influence the insulin and AMPK signaling pathways and could contribute to the early prediction of GDM. </p>
Principles of territory zoning as a basis for planning linear objects
Authors: Tikhonova K. V. , Kutsenko M. M. , Ozerov A. A. 
Published: August 2022

Functional zoning of the territory is the basis for the effective development of the land, the place-ment of linear objects is also part of the zoning process of the territory.
This article presents the results of the analysis of the main regulatory documents necessary for the development and planning of the territory.
Linear objects are quite complex objects for the formation of documentation on them, further regis-tration and registration.
Despite the issue of preparing cadastral documentation that has been worked out from the point of view of legislation, as well as the vast practical experience of entering information about linear ob-jects both in the EGRN and in other related resources, the placement of each object is a unique process that requires additional research. This circumstance determines the relevance of the research topic.
La memoria y el río. Sobre Tratamiento homeopático del Río de la Plata (2013) de Eduardo Navarro
Authors: Wrobel Iván , Bruno Garcén Paula 
Published: August 2022

¿El agua recuerda? ¿Cómo es posible visualizar y sanar su memoria? En el año 2013 el artista Eduardo Navarro presentó su obra Tratamiento homeopático del Río de la Plata en el Parque de la Memoria - Monumento a las Víctimas del Terrorismo de Estado, como parte de la exhibición Aquella mañana fue como si recuperara, si no la felicidad, sí la energía, una energía que se parecía mucho al humor, un humor que se parecía mucho a la memoria, bajo la curaduría de Inés Katzenstein y Javier Villa. En palabras del artista, el proyecto se inspiró en la teoría del científico japonés Masaru Emoto, quien sostiene que las diversas formas de cristalización del agua se deben a las energías y afectos a las que ésta se expone.
Data Forecasting of Air-Conditioning Load in Large Shopping Malls Based on Multiple Nonlinear Regression
Authors: Wang Lihui 
Published: August 2022

Abstract
This article applies multiple nonlinear regression methods to establish a forecasting model for the load characteristics of air conditioning in shopping malls at different times. Based on Python data, determine the functional relationship of refrigerant parameters concerning pressure and temperature. The article uses kernel smoothing estimation technology to calculate the room temperature probability density distribution of users participating in DLC to characterize the user’s comfort. The article’s research results show that the average error between the regression analysis results of refrigerant parameters and the reference value is within 1%. This model is suitable for medium and long-term load forecasting. It has high prediction accuracy for the sudden change trend with a turning point.
Where the Trees Stood in Water
Authors: Bitchell Bam , Mitchell Alexis , Bamboat Sharlene 
Published: August 2022

Where the Trees Stood in Water is a series of Cyanotype prints tracing the historic and contemporary transformations of Toronto’s Entertainment District. Each print is accompanied by an archival document which forms a narrative connecting geography to stories of colonization, industrialization and the transient bodies of those affected by the remaking of Toronto’s landscape. Juxtaposing text and image, Where the Trees… pushes against the archival documentation of Toronto’s past and challenges the stories told about colonialism, labour and migration. With playful reproductions, Bambitchell invites hidden, obscured, lost, and silenced narratives of colonial history to surface and tell new stories about the geography of Toronto’s core.
Queer Theory for Lichens
Authors: Griffiths David 
Published: August 2022

An article published in The Quarterly Review of Biology in December 2012 ended with the sentence: “We are all lichens.” The article discusses symbiosis in organisms such as lichens as well as in humans, to argue that humans cannot be thought of as individuals by any biological criteria. In this article I follow this argument and offer a brief naturalcultural history of lichens to illustrate their argument and the work of biologist Lynn Margulis on symbiogenesis. Following this, I ask: if we have never been human – if we are all composites like lichens – then what does this mean for sexuality? I argue that lichens and other symbioses can open up a queer ecological perspective that can help counter the privileging of heteronormativity and sexual reproduction, and that this has consequences for both science and society.
La Búsqueda de Visión como potenciadora de resiliencia en situaciones de aislamiento e incertidumbre
Authors: Mendoza Verónica Trujillo , Morón Carlos Edwin 
Published: August 2022

Una de las iniciativas para la contención de la pandemia fue el confinamiento. En su atención, la OMS recomendó el contacto virtual para mitigar la tristeza y estrés. La población relacionada con la cosmovisión de comunidades originarias resolvió esta cuestión a través del ritual Búsqueda de Visión. Por tanto, interesa describir de qué manera la participación en esta práctica influyó para asumir el confinamiento, así como los procesos anímicos derivados. Tal preocupación busca reconocer de qué manera un ritual permite establecer procesos para asumir el miedo y la depresión. La prenoción desde la que se intenta responder implica que los Buscadores, han encontrado maneras integrales de transitar el confinamiento, derivadas del proceso voluntario de aislamiento. Esta condición resiliente se presenta debido a que la experiencia vivida en el ritual permite un espectro de tolerancia más amplio a circunstancias emergentes. En esta exploración se recuperan algunos aportes críticos sobre la condición emotiva del ser humano en la actualidad, así como la importancia que tiene la pérdida de la conducta ritual en ello.
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One of the initiatives to contain the Sars-Cov-2 was the lockdown. The OMS recommended the virtual interaction to prevent sadness and stress. Some indigenous people solved this issue through his participation in a Vision Quest ritual. The central issue of this reflection to describe how the practice of this ritual influenced to face the lockdown, and the emotional processes of the people. This essay seeks to know how the ritual allows to assume the fear and depression. The proposal for those question is: the vision questers has found integral ways to confront the lockdown because the voluntary processes of isolation. The vision quest helps the people to be resilient because the voluntary isolation gives them abilities to face emergent situations. For this paper we use some critic concepts of emotional condition of human being and the importance of the loss of ritual behavior proposed by Byung-Chul Han.