bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Selection Criteria for Some Barley Genotypes under Different Water Stress Treatments
Authors: Mariey Samah A. , Khatab Ismael A. , Shahein Alaa M. E. A. , Abo-Marzoka EL-Sayed A. , Noreldin Tahany , Badawy Asmaa F. , El-Naggar A. A. 
Published: December 2022

Nowadays, water scarcity is a great danger to agriculture development, in semiarid and arid regions beside climate change risks. Egypt is suffering from scarce water resources for agriculture; it is of high priority to rationalize irrigation water use. During two seasons, 2019/2020 and 2020/2021 the experimental were carried out to investigate the effect of three different irrigation water treatments (I1 at 45, I2 at 60 and I3 at 75% depletion of available soil moisture) on some photosynthetic, agronomical, grain quality parameters, water productivity for eight barley genotypes. Also, classify them on the SSR molecular level. The results showed that there were high genetic variations found among the eight genotypes with significant responses to irrigation water treatments. Rationalize irrigation water from I1 to I3 had a negative effect on all studied phenotypic traits, whereas had an appositive effect on leaf diffusive resistance and cured protein content and inducement all genotypes to flower early by average increasing (27.7, 12.7 and 7.08%) respectively. Giza 138, Giza 131, and Line 4 gave high mean performance values of the measured characters besides, attaining high WP values were 1.14, 1.08, and 0.89 kg grain/m3 applied water I1, I2, and I3 irrigation treatments, respectively. While, WUE values increased with increasing water availability. Water use efficiency values were 1.92, 1.71, and 1.34 kg grain/m3 consumed water for I1, I2, and I3 irrigation treatments, respectively. Twenty-six alleles were generated using ten SSR primers with a mean value of 2.6 alleles per locus. The Polymorphism Information Content (PIC) value of each SSRs marker ranged from 0.33 (Bmag 0387) to 0.47 (Bmac 0167) with an average value of 0.34. Cluster analysis clustered the eight barley genotypes into two major clusters divided according to their response to water stress tolerance. The genetic information about eight barley genotypes for water stress tolerance was established, for use them in breeding programs in Egypt.
Micrometer‐Scale Optical Web Made of Spider Dragline Fibers with Optical Gate Operations
Authors: Hendra  , Yamagishi Hiroshi , Heah Wey Yih , Malay Ali D. , Numata Keiji , Yamamoto Yohei 
Published: December 2022

AbstractDragline silk fibers produced by spiders are a masterpiece structural protein that is durable even in the wild conditions. Dragline silk fibers are known to have excellent mechanical toughness and flexibility and further possess optical transparency, which are highly promising as textiles, sensors, and optical devices. Here, the authors show that the dragline silk microfibers act as good optical waveguides with the optical loss coefficient as small as 0.03 decibel per micrometer. The light transportation in the dragline silk fiber is performed by fluorescence energy transfer between two microspheres located on a suspended dragline silk microfiber. By utilizing a micromanipulation equipment, micrometer‐scale spider web‐like structures are fabricated. The experimentally observed optical waveguiding properties of the weaves match well with simulation results using simple mathematical models. Furthermore, optical logic gate operations are demonstrated using photoswitchable microsphere resonators attached on the dragline fibers.
Arbitrary Polarization Readout with Dual‐Channel Neuro‐Metasurfaces
Authors: Wang Zhedong , Qian Chao , Fan Zhixiang , Chen Hongsheng 
Published: December 2022

AbstractPolarization, as a vector nature of the electromagnetic wave, plays a fundamental role in optics. Determining the polarization state of light is required by many applications, spanning from remote sensing and material analysis to biology and microscopy. To achieve this goal, conventional methods necessitate cascading of multiple optical components and consequential measurements to estimate the Stokes parameters, rendering the entire optical system bulky, complex, and sensitive. Here a brand‐new strategy is introduced for direct polarization readout based on dual‐channel neuro‐metasurfaces. Neuro‐metasurfaces can independently manipulate two orthogonal linearly‐polarized waves that can synthesize arbitrary polarization waves with a linear combination. By judiciously designing the output focus points, a unique polarization atlas is created that allows one‐to‐one correspondence from intensity ratio to polarization state. To implement this, polarization‐sensitive metasurfaces are designed and the spatial layout is optimized using a diffractive neural network. The feasibility of this strategy is validated by numerical simulation and microwave experiments. These results pave a new avenue in realizing integrated and multifunctional detectors and demonstrate the potential of neuro‐metasurfaces as an add‐on for discomposing and composing spatial basis.
Ein Verbindung‐I‐Analogon deckt die vorübergehende aktive Spezies eines Zytochrom‐P450‐Enzymes auf: Einblick in die Stereoselektivität P450‐katalysierter Oxidationen
Authors: Suzuki Kazuto , Stanfield Joshua Kyle , Omura Keita , Shisaka Yuma , Ariyasu Shinya , Kasai Chie , Aiba Yuichiro , Sugimoto Hiroshi , Shoji Osami 
Published: December 2022

AbstractDas Erfassen der Struktur von Zytochrom‐P450‐Enzymenin flagrantiist für die Entwicklung von P450‐Biokatalysatoren von entscheidender Bedeutung, da die meisten der bisher erfassten Strukturen in einer präkatalytischen Konformation gefangen sind. Das Herzstück der P450‐Katalyse ist Verbindung I (Vbd I), ein kurzlebiges, hochreaktives Zwischenprodukt, dessen widerspenstige Art die Mehrheit der Versuche vereitelt hat, katalytisch bedeutsame Konformationen von P450 zu erfassen. Wir zeigen die Kristallstruktur von P450BM3, die den Zustand genau im Momente vor der Epoxidierung nachahmt, der mit den experimentell ermittelten Stereoselektivitäten perfekt übereinstimmt. Die Kristallisation wurde durch Bindung des stabilen Vbd‐I‐Analogons Oxomolybdänmesoporphyrin IX an P450BM3 in Gegenwart Styrols erreicht. Die relative Ausrichtung Styrols zur Molybdän‐Sauerstoff‐Spezies in den Kristallstrukturen wirft ein Licht auf die Dynamik, die an der Drehung Styrols beteiligt ist, um seine Vinylgruppe Vbd I darzubieten. Diese Methode dient als leistungsfähiges Instrument zur Vorhersage und Modellierung der Stereoselektivität von P450‐Reaktionen.
Transition‐Metal‐Free Controllable Single and Double Difluoromethylene Formal Insertions into C−H Bonds of Aldehydes with TMSCF2Br
Authors: Liu An , Ni Chuanfa , Xie Qiqiang , Hu Jinbo 
Published: December 2022

AbstractWe have developed a new strategy for controllable single and double difluoromethylene (CF2) formal insertions into C−H bonds of aldehydes with nearly full selectivity under transition‐metal‐free conditions. The key to the success of controllable CF2 insertions lies in the well‐defined formation of 2,2‐difluoroenolsilyl ether and 2,2,3,3‐tetrafluorocyclopropanolsilyl ether intermediates using difluorocarbene reagent TMSCF2Br (TMS=trimethylsilyl). These two intermediates can react with various electrophiles including proton sources and various halogenation reagents, allowing for the access to diverse arrays of ketones containing difluoromethylene (CF2) and tetrafluoroethylene (CF2CF2) units. The first synthesis of relatively stable 2,2,3,3‐tetrafluorocyclopropanolsilyl ethers has been achieved, which offers a new platform to explore other unknown chemical space.
Implementing life cycle sustainability assessment for improved space mission design
Authors: Wilson Andrew R. , Vasile Massimiliano , Maddock Christie , Baker Keith 
Published: December 2022

Abstract
Within the space sector, the application of Environmental Life Cycle Assessment (E-LCA) is beginning to emerge as a credible and compelling method for scientifically quantifying environmental impacts of space missions. However, E-LCA does not fully align with the concept of triple-bottom-line sustainability, while the combination of all three sustainability dimensions (environment, society, and economy) within a single life cycle study has thus far never been attempted within the space industry. Moving toward a Life Cycle Sustainability Assessment (LCSA) is, therefore, a logical next step for the space sector to allow these three sustainability dimensions to be addressed. Consequently, this article presents the underlying principles of a new LCSA framework for space missions and demonstrates its applicability for improving system-level design concepts based on the interaction between sustainability dimensions. The framework was formed based on a systematic literature review to analyze the background, issues, and knowledge gaps related to life cycle methodologies, as well as context-specific sustainability aspects. The framework has been implemented within a life cycle database called the Strathclyde Space Systems Database (SSSD). Using the SSSD, the framework was tested on a mission concept called Moon Ice Observation Satellite to demonstrate how changes in the design for a circular economy and other sustainability-based principles will affect the functionality of the mission at the system level. It is envisaged that this framework will enable engineers to create sustainable space systems, technologies, and products that are not only cost-efficient, eco-efficient, and socially responsible, but also ones that can easily justify and evidence their sustainability. Integr Environ Assess Manag 2023;19:1002–1022. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Assessment of the sustainable use of chemicals on a level playing field
Authors: Everard Mark 
Published: December 2022

Abstract
Misleading conclusions can result from applying tools beyond the purposes for which they were designed. A range of chemical assessment systems was compared against a set of principles germane to the sustainable use of chemicals relevant to the whole societal life cycles of finished products. These principles of sustainable use included: wider dimensions of sustainability, a foundation in science, consideration of life-cycle risk rather than simply intrinsic chemical properties, contributions to meeting human needs, open access, and peer review. A transparent basis in science is important for deriving objective, comparable, and replicable sustainability-based findings across materials and applications, and for guiding innovation. Few assessment systems currently identify how use of substances contributes to meeting human needs, a vital albeit often overlooked aspect of sustainable development, with most based largely on potential hazard without addressing wider life-cycle exposure and risk assessment. Qualitatively differing substances were illustratively assessed against the sustainability principles and life-cycle context of the Additive Sustainability Footprint (ASF), aspects of this analysis highlighting how differing material sourcing, manufacturing, and management in-use and at end-of-life can lead to widely divergent sustainability assessments. These illustrative ASF assessments also demonstrate that material use challenges, assessed on a systemic basis, are common across materials, with no defensible automatic assumption that there are inherently “good” or “bad” materials; differing stewardship across whole product life cycles substantially influences sustainability credentials for all materials. It is therefore important that the sustainability performance of all materials is assessed on an objective “level playing field,” which also highlights “hot spots” for sustainable innovation from supply-chain management through manufacturing, substance selection by material compounders, maintenance inputs in product use, and beyond product end-of-life. Chemical regulation must evolve to include and embed wider sustainability principles into operational practice and become applicable and enforced across increasingly global value chains. Integr Environ Assess Manag 2023;19:1131–1146. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Peritoneal recurrence after resection for Stage I–III colorectal cancer: A population analysis
Authors: Aiken Taylor , Hu Chung‐Yuan , Uppal Abhineet , Francescatti Amanda B. , Fournier Keith F. , Chang George J. , Zafar Syed Nabeel 
Published: December 2022

AbstractBackgroundColorectal cancer (CRC) often recurs in the peritoneum, although the pattern of peritoneal recurrence (PR) has received less attention. We sought to describe the presentation and risk factors for PR following CRC resection.MethodsWe performed a cohort study of patients undergoing resection of Stage I–III CRC from 2006 to 2007 using merged data from a Commission on Cancer Special Study and the National Cancer Database. We estimated the timing, method of detection, and risk factors for isolated PR.ResultsHere, 8991 patients were included and isolate PR occurred in 77 (0.9%) patients. The median time to PR was 16.2 months (intrquartile range = 9.3–28.0 months) and most patients were identified via new symptoms (36.4%). Pathologic factors associated with increased odds of PR included higher T stage (T3 vs. T2, odds ratio [OR] = 4.8, 95% confidence interval [CI] = 1.5–15.7), N stage (N1 vs. N0, OR = 2.00, CI = 1.1–3.7), and signet ring (OR = 8.2, CI = 3.0–22.3) or mucinous histology (OR = 2.6, CI = 1.5–4.7).ConclusionsThe majority of PR was detected within 18 months and few were identified by surveillance. Advanced T/N stage and signet ring/mucinous histology were associated with increased odds of PR.
Effect of bladder filling volume on detrusor contractility in men with bladder outlet obstruction
Authors: Hermieu Nicolas , Chesnel Camille , Teng Maëlys , Xylinas Evanguelos , Ouzaid Idir , Hermieu Jean‐François , Amarenco Gérard , Hentzen Claire 
Published: December 2022

AbstractIntroductionBladder outlet obstruction alters detrusor contractility, reducing the bladder's ability to respond to large filling with a risk of urinary retention.The objective was to assess the effect of bladder filling volume on detrusor contractility in men with bladder outlet obstruction.MethodsA prospective multicenter study in two pelviperineology departments. Male patients eligible for urodynamics (IPSS score > 7) were included from January to July 2022. In case of absence of bladder outlet obstruction on pressure‐flow studies, they were secondarily excluded. The primary endpoint was the maximum isometric detrusor pressure during a stop‐test, corresponding to detrusor contractility, measured at 3 filling volumes (50%, 75%, and 100% of cystometric capacity).ResultsFifty‐two patients performed urodynamics, of whom 12 were excluded because of lack of obstruction or inability to perform the stop‐test. Detrusor contractility was significantly higher for a 75% bladder filling than 50% and for a 75% filling than 100%, with a mean difference of 19.5; confidence interval (CI) 95% [14.3; 24.8] and 12.2; CI 95% [6.9; 17.5] cmH2O respectively (p < 0,01).ConclusionIn case of bladder outlet obstruction in men, detrusor contractility depends on bladder filling volume, with reduced contractility when the bladder was underfilled or overfilled. This phenomenon could help to explain the mechanisms of urinary retention in men with bladder outlet obstruction.
Improvement of interfacial adhesion of CuO nanostructured carbon fiber reinforced polymer composites
Authors: Rai Ravi Shankar , Bajpai Vivek 
Published: December 2022

AbstractHydrothermal technique was used to deposit copper‐oxide (CuO) nanostructures on woven carbon fibers (WCF) to produce a nanostructured interphase that increased the interfacial strength with an epoxy resin matrix. In order to create laminated hybrid composites, CuO‐modified WCF was reinforced with mixture of bisphenol‐A epoxy resin and dimethyl aniline hardener as matrix using the vacuum bagging approach. Enhanced mechanical qualities are the result of increased volume fraction of CuO nanostructures, where the void content is minimal. The mechanical characteristics such as impact strength and tensile strength of CuO‐coated WCF reinforced epoxy resin composite samples were assessed using drop‐down impact test and universal material testing system. The outcomes demonstrate a considerable improvement in impact energy absorption (74.8%), elastic modulus (52%) tensile strength (42%) and in‐plane shear strength (32%) for the CuO‐coated WCF reinforced epoxy resin composites. This work demonstrates that the development of CuO nanostructures can lessen composite delamination and enhance composite performance because of the increase in interfacial surface area between the matrix and the fiber by CuO nanostructures potentially expanding the spectrum of structural applications for these materials.
Competition in the deep sea: phylogeny determines destructive impact of wood-boring xylophagaids (Mollusca: Bivalvia)
Authors: Voight Janet R. , Heck Philipp R. , Du Clos Kevin T. 
Published: December 2022

AbstractHow biotic interactions contribute to structuring deep-sea communities remains poorly known. An example of exploitation competition, in which over time one species dominates a habitat to preclude its use by competitors, is highlighted here. Sunken wood is the obligate habitat of deep-sea wood borers of the Xylophagaidae Purchon, 1941 which eat wood and, with symbiotic bacteria, digest it. Enigmatically, some wood falls remain robust despite xylophagaid boring. Xylophagaids bore other wood falls so heavily that they crumble after just a few months. We perform a meta-analysis of experimental wood deployments and view the results from a phylogenetic perspective. Of 15 deployments recovered after 5 to 25 months from 200 to 3232 m deep, seven were so heavily bored to be crushable by hand. Eight were bored but remained robust. The groups did not significantly differ in wood size, type, temperature, depth, or duration. Members of theXylophaga dorsalis(Turton, 1819) clade, reported in two studies to recruit and bore faster than confamilials, bored all seven crushable deployments; seven of the eight intact deployments were bored by other xylophagaids. Fecal chimneys line and thus narrow the boreholes of this clade; fluid flow is impeded, a clear liability. The lignin-rich fecal chimneys may, however, cue larval settlement and at resultant high population densities, lower oxygen availability. Members of theX. dorsalisclade, being hypoxia-tolerant, thrive but other xylophagaids appear to suffer, perhaps due to interference competition. The shared derived characters that unite this clade allow them to exploit low-oxygen wood that is intolerable for competitors.
Changes in neutrophile-to-lymphocyte ratio as predictive and prognostic biomarker in metastatic prostate cancer treated with taxane-based chemotherapy
Authors: Neuberger Manuel , Weiß Christel , Goly Nora , Skladny Janina , Nitschke Katja , Wessels Frederik , Kowalewski Karl F. , Waldbillig Frank , Hartung Friedrich , Nientiedt Malin , Egen Luisa , Herrmann Jonas , Jarczyk Jonas , Walach Margarete Teresa , Kriegmair Maximilian C. , Westhoff Niklas , Worst Thomas S. , Nuhn Philipp 
Published: December 2022

Abstract
Objectives
To assess the predictive and prognostic value of changes in longitudinal neutrophile-to-lymphocyte (NLR) ratios in men receiving taxane-based chemotherapy for metastatic prostate cancer (PC).

Methods
Retrospective, unicentric cohort study of patients treated with either docetaxel for metastatic hormone-sensitive PC (mHSPC) or docetaxel or cabazitaxel for metastatic castration-refractory PC (mCRPC) at a tertiary referral hospital between 2010 and 2019. NLR ratios were calculated for each cycle. Next, slopes over the first three (NLR3) and over six cycles (NLR6) were calculated and analysed for biochemical/radiologic response and survival.

Results
A total of 36 mHSPC (docetaxel), 118 mCRPC (docetaxel) and 38 mCRPC (cabazitaxel) patients were included. NLR3 was significantly associated with 1-year-survival, radiographic and biochemical response in mCRPC (docetaxel) in uni- and multivariable analyses. In mCRPC (docetaxel), positive NLR3s were associated with favourable 1-year-survival.

Conclusion
This study demonstrated NLR3 as a prognostic marker in men receiving docetaxel for mCRPC. NLR3 might be a clinical tool to reflect the individual’s response to taxane-based chemotherapy. Thereby, NLR3 could complement existing biomarkers and help to early identify treatment failure before complications arise. Further prospective and multicentric studies are needed to extend and confirm the presented results.
Using Storytelling to Promote Organizational Resilience: An Experimental Study of Different Forms of Risk Communication
Authors: Kampmann Andrea , Pedell Burkhard 
Published: December 2022

AbstractIn this experimental study, we compare the influence of risk communication in the form of stories versus statistics on the level of investment in a resilience-promoting activity. We also analyze how this influence interacts with time gap and with an individual’s preferences for risk and numbers. The results indicate that individuals invest more in a resilience-promoting activity when communication comes as a story. This finding holds irrespective of an individual’s risk preference. The results did not confirm the expectation that communication in story form leads to a more enduring effect than communication in statistical form. The expectation that the preference for numbers influences the effectiveness of a specific communication form was also not confirmed.
Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity
Authors: Centofanti Federica , Alonzi Tonino , Latini Andrea , Spitalieri Paola , Murdocca Michela , Chen Xiaodong , Cui Weibo , Shang Qianwen , Goletti Delia , Shi Yufang , Duranti Andrea , Tomino Carlo , Biancolella Michela , Sangiuolo Federica , Capobianchi Maria Rosaria , Jain Suresh , Novelli Giuseppe , Pandolfi Pier Paolo 
Published: December 2022

AbstractThe effects of indole-3-carbinol (I3C) compound have been described deeply as antitumor drug in multiple cancers. Herein, I3C compound was tested for toxicity and antiviral activity against SARS-CoV-2 infection. Antiviral activity was assessed in vitro in both in VeroE6 cell line and human Lung Organoids (hLORGs) where I3C exhibited a direct anti-SARS-CoV-2 replication activity with an antiviral effect and a modulation of the expression of genes implicated in innate immunity and inflammatory response was observed at 16.67 μM. Importantly, we further show the I3C is also effective against the SARS-CoV-2 Omicron variant. In mouse model, instead, we assessed possible toxicity effects of I3C through two different routes of administration: intragastrically (i.g.) and intraperitoneally (i.p.). The LD50 (lethal dose 50%) values in mice were estimated to be: 1410 and 1759 mg/kg i.g.; while estimated values for i.p. administration were: 444.5 mg/kg and 375 mg/kg in male and female mice, respectively. Below these values, I3C (in particular at 550 mg/kg for i.g. and 250 mg/kg for i.p.) induces neither death, nor abnormal toxic symptoms as well as no histopathological lesions of the tissues analysed. These tolerated doses are much higher than those already proven effective in pre-clinical cancer models and in vitro experiments. In conclusion, I3C exhibits a significant antiviral activity, and no toxicity effects were recorded for this compound at the indicated doses, characterizing it as a safe and potential antiviral compound. The results presented in this study could provide experimental pre-clinical data necessary for the start of human clinical trials with I3C for the treatment of SARS-CoV-2 and beyond.