bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between overactive bladder and fibromyalgia: A systematic review and meta‐analysis
Authors: Goldberg Nitzan , Tamam Shai , Weintraub Adi Y. 
Published: June 2022

AbstractBackgroundOveractive bladder is a common syndrome that significantly affects the quality of life. Fibromyalgia is characterized by widespread pain, impacting patients' lives. The exact mechanisms of the two syndromes remain unknown, but there is an overlap between the suspected pathophysiologies.ObjectiveTo present an overview of the current research on the association between overactive bladder (OAB) and fibromyalgia.Search strategyA systematic search of four electronic databases was conducted.Search strategyStudies examining the correlation between OAB and fibromyalgia with female patients aged over 18 years were included.Data collection and analysisTwo reviewers screened the studies for eligibility. Eligible studies were screened for quality. A meta‐analysis was performed for eligible studies.Main resultsSeven studies were included in the final review, of which six presented a positive association between the syndromes. The studies demonstrated a positive association between fibromyalgia and the severity of OAB and an adverse effect on the quality of life related to OAB. A mean effect size of 1.96 (95% confidence interval 0.85–3.06) was calculated.ConclusionOAB and fibromyalgia are both complex and multifactorial syndromes. The study presents an association between them, but additional studies on the topic should be conducted for a more precise conclusion.
Feasibility of Raman spectroscopy as a potential in vivo tool to screen for pre‐diabetes and diabetes
Authors: Guevara Edgar , Torres‐Galván Juan Carlos , González Francisco Javier , Luevano‐Contreras Claudia , Castillo‐Martínez Claudio Cayetano , Ramírez‐Elías Miguel G. 
Published: June 2022

AbstractIn this article, we investigated the feasibility of using Raman spectroscopy and multivariate analysis method to noninvasively screen for prediabetes and diabetes in vivo. Raman measurements were performed on the skin from 56 patients with diabetes, 19 prediabetic patients and 32 healthy volunteers. These spectra were collected along with reference values provided by the standard glycated hemoglobin (HbA1c) assay. A multiclass principal component analysis and support vector machine (PCA‐SVM) model was created from the labeled Raman spectra and was validated through a two‐layer cross‐validation scheme. Classification accuracy of the model was 94.3% with an area under the receiver operating characteristic curve AUC of 0.76 (0.65–0.84) for the prediabetic group, 0.86 (0.71–0.93) for the diabetic group and 0.97(0.93–0.99) for the control group. Our results suggest the feasibility of using Raman spectroscopy for the classification of prediabetes and diabetes in vivo.
Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles
Authors: Crivelli Simone M. , Giovagnoni Caterina , Zhu Zhihui , Tripathi Priyanka , Elsherbini Ahmed , Quadri Zainuddin , Pu Jian , Zhang Liping , Ferko Branislav , Berkes Dusan , Spassieva Stefka D. , Martinez‐Martinez Pilar , Bieberich Erhard 
Published: June 2022

AbstractThe formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we report that the ceramide transport protein (CERT) mediates a non‐vesicular transport of ceramide between the endoplasmic reticulum (ER) and the multivesicular endosome at contact sites. The process depends on the interaction of CERT's PH domain with PI4P generated by PI4KIIα at endosomes. Furthermore, a complex is formed between the START domain of CERT, which carries ceramide, and the Tsg101 protein, which is part of the endosomal sorting complex required for transport (ESCRT‐I). Inhibition of ceramide biosynthesis reduces CERT‐Tsg101 complex formation. Overexpression of CERT increases EV secretion while its inhibition reduces EV formation and the concentration of ceramides and sphingomyelins in EVs. In conclusion, we discovered a function of CERT in regulating the sphingolipid composition and biogenesis of EVs, which links ceramide to the ESCRT‐dependent pathway.
A quality improvement project reduces time spent at an inflammatory bowel disease infusion center with accelerated infliximab infusion protocol
Authors: Ong Wan Chee , Lim Miao Shan , Chan Elaine , Lim Thomson Chong Teik , Lim Teong Guan , Chan Webber 
Published: June 2022

AbstractBackground and AimPatients with inflammatory bowel disease (IBD) requiring infliximab frequently spend hours to attend treatment. Through quality improvement (QI) methodology, we aimed to shorten the time spent in the biologics infusion center using the accelerated infusion protocol and describe patient outcomes, safety, and associated cost savings.MethodsFrom September 2018 through December 2019, eligible IBD patients receiving infliximab were recruited. We implemented interventions including the accelerated infusion protocol, and modifying collection location of infliximab. Statistical process control charts were created. Patients' clinical outcome and cost savings data were analyzed using descriptive statistics and Pearson's chi‐square.ResultsDuring the study period, a total of 60 patients with IBD receiving infliximab were recruited. A total of 315 infusions were administered—152 were under accelerated infusion protocol and 163 under standard protocol. The mean infliximab infusion time was reduced by 47%, from 2.4 h (142 ± 14 min) to 1.2 h (75 ± 10 min) (142 min vs 75 min, P < 0.001), with total time spent in the infusion center reduced by 52%, from 3.6 h (214 ± 25 min) to 1.7 h (102 ± 14 min) (214 vs 106 min, P < 0.001). Three mild infusion‐related reactions (3/152 = 1.97%) were recorded. Estimated cost savings over the 16‐month project period was SGD $6721.4 (nursing) and SGD $23 560 (patients). A high level of satisfaction (4.84 out of 5) with the protocol was reported.ConclusionOur QI project shortened the infliximab infusion time and total time spent in the infusion center, without compromising patient safety. Estimated cost savings were substantial. The protocol helps reduce work productivity loss.
Facile and environmentally benign synthetic approach to the selective mono‐chlorination and mono‐bromination of benzo[d]OXAZOL‐2(3H)‐ONES
Authors: Kurutos Atanas , Minkovska Stela , Nedialkov Paraskev T. , Fedorov Yury V. 
Published: June 2022

AbstractExhibiting a wide spectrum of practical applications, benzo[d]oxazol‐2(3H)‐ones (BOA) are considered as key intermediates in the synthesis of pharmaceutical products, organic dyes, and OLED materials among others. Herein, we propose an environmentally benign protocol for the selective mono‐halogenation of benzo[d]oxazol‐2(3H)‐ones. Several chloro‐ and bromo‐substituted BOA derivatives were prepared within less than an hour with high to excellent yields (75%–93%) via this novel, green, and energy sufficient method. This rapid and highly reproducible synthetic approach employs inexpensive commercially available urea‐hydrogen peroxide complex and hydrochloric or hydrobromic acid. Simple operations and precise control over the oxidative halogenation, with water being the major by‐product of the reaction outcome, are among the strong point of current facile method from the perspective of green chemistry.
Synthesis of pyrazole tethered oxadiazole and their analogs as potent antioxidant agents
Authors: Reddy Guda Mallikarjuna , Zyryanov Grigory V. , Basha Nabhubygari Mahaboob , Munagapati Venkata Subbaiah , Wen Jet‐Chau , Gollakota Anjani R. K. , Shu Chin‐Min , Venkatesh Bhumireddy Chinnachennaiahgari 
Published: June 2022

AbstractPreparation of organic compounds in environmental favor media always a fresh tool in the synthetic research. If those prepared compounds may possess therapeutically potentiality, then it called as efficient research. Herein, we report the 12 new oxadiazole linked carboxamide pyrazole substances have been synthesized and screened for their free radical scavenging activity by using hydrogen peroxide (H2O2), nitric oxide (N2O), and diphenyl picryl hydrazide (DPPH) methods. All the compounds displayed reliable biological properties. Among them, compound 8f hold high antioxidant activity may be due to the presence of methoxy group at para position of benzene ring. From the synthetic point of view, this is the novel environment favor method for the synthesis of pyrazole linked oxadiazoles, and the biological results of these compounds may stand as a referee for further development of biologically active pyrazole tethered oxadiazoles.
Usefulness of high‐risk HPV early oncoprotein (E6 and E7) serological markers in the detection of cervical cancer: A systematic review and meta‐analysis
Authors: Singini Mwiza Gideon , Singh Elvira , Bradshaw Debbie , Ramaliba Thendo , Chen Wenlong Carl , Motlhale Melitah , Kamiza Abram Bunya , Babb de Villiers Chantal , Muchengeti Mazvita , Mathew Christopher G. , Newton Robert , Bender Noemi , Waterboer Tim , Sitas Freddy 
Published: June 2022

AbstractWe reviewed the literature on the importance of selected anti‐high‐risk human papillomavirus (HR‐HPV) antibodies (namely, 16/18 and early oncoproteins E6 and E7) as potential serological markers for early detection of individuals at high risk of cervical cancer. We searched for studies in PubMed and Embase databases published from 2010 to 2020 on antibodies against HR‐HPV E6 and E7 early proteins and cervical cancer. Pooled sensitivity and specificity for HPV16 and HPV18 antibodies were calculated using a bivariate hierarchical random‐effects model. A total of 69 articles were identified; we included three studies with 1550 participants. For the three HPV16/18 E6 and E7 antibody tests, enzyme‐linked immunosorbent assay‐based assays had a sensitivity of 18% for detecting CIN2+ (95% confidence interval [CI]: 15–21) and a specificity of 96% (95% CI: 92–98), for slot‐blot, sensitivity was 28.9% (95% CI: 23.3–35.1) and specificity was 72% (95% CI: 66.6–77.0) for detecting CIN2+, and for multiplex HPV serology assay based on a glutathione S‐transferase, sensitivity was 16% (95% CI: 8.45–28.6) and specificity was 98% (95% CI: 97–99) for detecting invasive cervical cancer. HR‐HPV16/18 E6 and E7 serological markers showed high specificity, but sensitivity was suboptimal for the detection of cervical cancer in either population screening settings or as point‐of‐care screening tests.
Scaffolding students’ career readiness via the e‐micromodule route
Authors: Lee ChienChing 
Published: June 2022

AbstractThe future of work is changing with many expected to have multiple micro‐careers. Thus, workers should be supported to be career‐ready in a scalable and intentional manner. The aim of this exploratory study is to investigate the effects of a career planning e‐micromodule on preinternship students’ career readiness using the lens of Social Cognitive Career Theory and NACE's Career and Self‐development competency. The results showed a statistically significant difference in the self‐efficacy pre‐ and posttraining survey scores on career readiness for all items, while their open‐ended responses reflected plans on navigating career opportunities, identifying their strengths, learning continuously, and building positive working relationships.
A rare entity: Benign osteonecrosis of the temporal bone
Authors: Whittaker Alexandra G. , McKinnon Brian J. 
Published: June 2022

AbstractObjectiveTo investigate the factors that may contribute to the rare disease process of benign osteonecrosis of the temporal bone and to differentiate this poorly understood disease from other disorders.MethodsA retrospective chart review using tertiary academic medical center electronic medical records (EMR) for otolaryngology was performed in August 2021. The study included data from January 1, 2014, to June 30, 2020. The patients were identified by a series of predetermined criteria. Their demographic information and clinical course were qualitatively compared. Patients with a history of radiation to the head or neck or who had other otolaryngologic comorbidities were excluded from the study. Inclusion/exclusion criteria were used to filter patients and a thorough chart review was conducted among the patients identified.ResultsA total of three patients were identified that met criteria for the study upon thorough chart review. Out of these patients, all were male, fell within the age range of 67–78 years old and had a history of hypertension. Two out of three had diabetes. In all cases, the plan included supportive care and regular follow up appointments.ConclusionBenign osteonecrosis of the temporal bone is a rare disease that is difficult to diagnose and even more complicated to document. There is no specific ICD‐10 code for this disease making it exceedingly difficult to identify patients with a simple EMR search. Several previously hypothesized risk factors were studied in this review. The limited patient population makes it difficult to confidently identify risks. In the patients studied, the commonalities included that they were all men, above the age of 67 when diagnosed, and all had a history of hypertension. To fully understand this rare entity further research must be conducted and more patients must be studied to aid with the identification of risk factors and clinical diagnosis of this condition.Level of Evidence: 4.
Achieving Hydrophobic Ultralow Dielectric Constant Polyimide Composites: Combined Efforts of Fluorination and Porous Fillers
Authors: Zhao Wanjing , Lu Chonghao , Zhao Hui , Huang Jingshu , Zha Jun‐Wei , Cao Xianwu , Li Robert K. Y. , Wu Wei 
Published: June 2022

AbstractThe advancement of the microelectronics industry necessitates the use of interlayer insulation materials with low dielectric constants and high mechanical properties. In this paper, a new type of copolymerized fluorinated polyimide (PI) is synthesized, and mixed with polyhedral oligomeric silsesquioxane (POSS) functionalized mesoporous silica (MCM‐41@POSS). The PI/MCM‐41@POSS composites exhibit good hydrophobicity. With the addition of 3 wt% MCM‐41@POSS, the PI composite attained an ultralow dielectric constant (k = 1.88) and low dielectric loss (0.01) at 1 MHz, which is attributed to the mesoporous structure of MCM‐41 and the restriction of polarization in the bonded region. The decorated POSS effectively prevents the penetration of PI molecular chains into the mesopores of MCM‐41. In addition, the PI composites containing 3 wt% of MCM‐41@POSS obtain the highest maximum stress of 104.03 MPa with an elongation at break of 13.73%. The hydrophobic PI composites with ultralow‐k are expected to be good candidates as interlayer materials in microelectronics devices.
Decoupling Segmental Dynamics and Ionic Transport for Superionic Anhydrous Proton Conductors of Polyoxometalate‐poly(ethylene glycol) Nanocomposites
Authors: Zheng Zhao , Li Mu , Lai Yuyan , Cao Youjin , Yin Panchao 
Published: June 2022

AbstractSuperionic anhydrous proton conductors can be obtained from the complexation of nanoscale polyoxometalates (POMs) and poly(ethylene glycol) (PEG) in the “polymer in salt” regime. The reduced energy barrier of H+ hopping is facilitated from the increased H+ concentration and shortened inter‐POM distances. POMs with identical structure/size (≈1 nm) but different charge densities are complexed with PEG, respectively, with concentrations ranging from 10 to 60 % wt. Increasing trends of viscosities can be observed with the rising charge densities of POMs due to the increasing confinement strength on PEG substrate from POMs. Fractional Walden rule is further applied to analyze the viscosity and proton conductivity correlations, and microscopic mechanisms of proton conduction for PEG‐POM nanocomposites are revealed: 1) ion transport is highly associated with polymer chain dynamic for POMs concentrations ranging from 10 to 30 % wt.; 2) ionic conduction is largely decoupled from chain dynamic of polymer matrix for concentrations ranging from 40 to 60 % wt. with Walden plots shifted to the superionic regime. The decoupling of proton transport from polymer segment dynamics allows the simultaneous enhancements of the nanocomposites’ mechanical properties and proton conductions, providing guidelines for the rational design of anhydrous proton conductors with integrated functionalities.
Combining Polymer Zwitterions and Zinc Oxide for High‐Performance Inverted Organic Solar Cells
Authors: Guo Yanan , Liu Ming , Yuan Chenyuhe , Ren Zhongjie , Liu Yao 
Published: June 2022

AbstractZinc oxide (ZnO) is a widely used cathode interlayer material in inverted organic solar cells (OSCs). However, there are lots of surfaces or bulk film defects in ZnO layers, which degrade solar cell performance. Here, the typical phosphorylcholine‐ and sulfobetaine‐based polymer zwitterions (PMPC and PDMAPS) are synthesized via reversible addition‐fragmentation chain‐transfer (RAFT) polymerization to modify ZnO interlayers for inverted OSCs. The polymer zwitterions can efficiently passivate the defects in ZnO films and thus increase the conductivity of the ZnO interlayers. Both PMPC and PDMAPS modified ZnO interlayers show some general advantages in improving the performance of fullerene‐based and non‐fullerene‐based OSCs. The highest efficiency of 16.69% is achieved by using PMPC modified ZnO interlayers in PM6:Y6 based solar cell devices, which is among the best performance in inverted OSCs. Such an improvement in device performance is attributed to the work function reduction of the polymer zwitterions modified ZnO films, which provides an efficient cathode platform to extract and transport electrons from the active layers, to the benefit of suppressing interfacial charge recombination. As a result, the organic‐inorganic hybrid composites (ZnO: polymer zwitterions) show efficient interfacial modification to align energy levels at the device interface, which have promising application prospects in organic electronics.
OSCILLATE: A low‐rank approach for accelerated magnetic resonance elastography
Authors: McIlvain Grace , Cerjanic Alexander M. , Christodoulou Anthony G. , McGarry Matthew D. J. , Johnson Curtis L. 
Published: June 2022

PurposeMR elastography (MRE) is a technique to characterize brain mechanical properties in vivo. Due to the need to capture tissue deformation in multiple directions over time, MRE is an inherently long acquisition, which limits achievable resolution and use in challenging populations. The purpose of this work is to develop a method for accelerating MRE acquisition by using low‐rank image reconstruction to exploit inherent spatiotemporal correlations in MRE data.Theory and MethodsThe proposed MRE sampling and reconstruction method, OSCILLATE (Observing Spatiotemporal Correlations for Imaging with Low‐rank Leveraged Acceleration in Turbo Elastography), involves alternating which k‐space points are sampled between each repetition by a reduction factor, ROSC. Using a predetermined temporal basis from a low‐resolution navigator in a joint low‐rank image reconstruction, all images can be accurately reconstructed from a reduced amount of k‐space data.ResultsDecomposition of MRE displacement data demonstrated that, on average, 96.1% of all energy from an MRE dataset is captured at rank L = 12 (reduced from a full rank of 24). Retrospectively undersampling data with ROSC = 2 and reconstructing at low‐rank (L = 12) yields highly accurate stiffness maps with voxel‐wise error of 5.8% ± 0.7%. Prospectively undersampled data at ROSC = 2 were successfully reconstructed without loss of material property map fidelity, with average global stiffness error of 1.0% ± 0.7% compared to fully sampled data.ConclusionsOSCILLATE produces whole‐brain MRE data at 2 mm isotropic resolution in 1 min 48 s.
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡
Authors: Khalique Saira , Nash Sarah , Natrajan Rachael 
Published: June 2022

AbstractThe ARID1A tumour suppressor protein is a component of the SWI/SNF chromatin remodelling complex, which is mutated in approximately 20% of all human cancers. ARID1A mutational status is considered to hold prognostic significance in a range of solid malignancies, yet in endometriosis‐related ovarian carcinomas there has been a lack of clarity of its prognostic role. Moreover, the relationship between ARID1A status and immune infiltrate is also poorly understood. In a recent issue of The Journal of Pathology, a large comprehensive study by Heinze, Nazeran et al addressed these areas by reviewing 1,623 endometriosis‐associated ovarian carcinomas and correlating ARID1A status using standardised immunohistochemistry to infer mutation status, with comprehensive clinicopathological features, mismatch repair status and CD8+ tumour infiltrating lymphocytes. The study definitively showed that ARID1A status does not provide any independent prognostic value in endometriosis‐associated ovarian carcinomas. ARID1A loss was, however, shown to be associated with mismatch repair deficiency and increased CD8+ tumour infiltrating lymphocytes in endometrioid ovarian carcinoma, which may be relevant for future studies. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Micro/nano particles reinforced polymer composites as greenhouse films for heat retention purposes
Authors: Yang Sheng , Wang Yang 
Published: June 2022

AbstractThe aim and objective of this review is to intensively summarize composite film materials that can achieve thermal radiation insulation without affecting visible light transmittance, in order to reduce the heat loss in greenhouses and thus save energy. Eight kinds of composite films, which could be used for radiation insulation, were finally determined and intensively reviewed by searching the key words including insulation film, insulation agent, and infrared insulation. These materials can be divided into two categories: silica/poly and zinc oxide/poly composites. The radiation thermal insulation property and light transmission property of these materials were experimentally tested by spectrometry. The key finding of this article includes that phonon resonance and Anderson localization could be used to block thermal infrared radiation by generalizing material properties. The conclusion of this review is that those materials have at least a 10% increase in infrared thermal radiation blocking, but only a small decrease in visible light transmittance.