bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaningfulness and self-integrity at work amongst older, self-employed women entrepreneurs
Authors: Lindström Sara , Ansio Heli , Steel Tytti 
Published: July 2022

PurposeThis study identifies how self-employed older women experience and represent self-integrity – an element and source of meaningfulness – in their work, and how these experiences are intertwined with gendered ageing.Design/methodology/approachThe authors used thematic analysis, influenced by an intersectional lens, to scrutinise qualitative data generated during a development project, with ten over 55-year-old self-employed women in Finland.FindingsThe study reveals three dominant practices of self-integrity at work: “Respecting one's self-knowledge”, “Using one's professional abilities”, and “Developing as a professional”. Older age was mostly experienced and represented as a characteristic that deepened or strengthened the practices and experiences of self-integrity at work. However, being an older woman partly convoluted that. Self-integrity as a self-employed woman was repeatedly experienced and represented in contrast to the male norm of entrepreneurship.Originality/valueThe authors contribute to the literature on gender and entrepreneurship by highlighting the processual dimensions – how integrity with self is experienced, created and sustained, and how being an older woman relates to self-integrity in self-employment. The results show a nuanced interplay between gender and age: Age and gender both constrain and become assets for older women in self-employment through older women's experiences of self-integrity.
Examining the role of microfinance: a creating shared value perspective
Authors: Rokhim Rofikoh , Lubis Arief Wibisono , Faradynawati Ida Ayu Agung , Perdana Winalda Ajaniara , Deni Yonathan Andrew 
Published: July 2022

Purpose
The purpose of this study is to simultaneously examine the role of microfinance from the business and social lenses by using the creating shared value (CSV) framework by Porter and Kramer (2011) in the context of Indonesia.

Design/methodology/approach
A survey among more than 170,000 borrowers of two specific credit schemes by PT Bank Rakyat Indonesia Tbk., the largest microfinance provider in Indonesia, was conducted to understand the perceptions of borrowers on the benefits of microcredit under the CSV framework.

Findings
The result confirms that, overall, the debtors acknowledged the importance of the loans in various aspects of CSV. The highest levels of importance were recorded in the case of stimulating the increase of business revenue growth, business productivity and fulfilling the needs of consumers. Disaggregating the results based on respondents’ demographic characteristics, it is shown that the findings in both credit schemes have a relatively similar pattern in terms of origin, business sectors and the borrowing purpose from.

Originality/value
There have been limited studies that examine the impact of microfinance from both the business and social perspectives. Most studies only use one of these. Implementing the CSV framework allows the authors to fill in the gap and understand how microfinance provides business and social benefits.
Collaborative space: framework for collaborative consumption and the sharing economy
Authors: Akbar Payam , Hoffmann Stefan 
Published: July 2022

Purpose
The purpose of this paper is to develop and introduce the new concept of the collaborative space.

Design/methodology/approach
Building on an extensive overview of past research and footing on extant conceptual work, the paper chooses an explicating conceptualization approach.

Findings
The paper presents the collaborative space, which features the three bipolar dimensions, namely, the type of consumption (access vs reownership), source of resource (company-owned vs consumer-owned) and the type of compensation (with vs without monetary fee). These dimensions open up multiple areas of the collaborative space, including the pseudo sharing economy, sharing ecology, redistribution markets and redistribution communities.

Research limitations/implications
The paper shows blind spots in the literature as well as the need to consider the consumption context to outline directions for future research.

Practical implications
For managers, this paper develops a foundation for entering, exploring and exploiting the collaborative space along the stages acquisition, distribution, consumption and compensation.

Social implications
Collaborative consumption is associated with community-building, resource saving and sustainability. The conceptualization of the collaborative spaces provides different options to enable more sustainable consumption and raise social exchange between consumers.

Originality/value
So far, an overarching framework that reveals similarities and differences of business models that are associated with collaborative consumption and the sharing economy is missing. This paper develops this framework, which is labelled the collaborative space.
Challenges in combating corruption in Malaysia: issues of leadership, culture and money politics
Authors: Jones David Seth 
Published: July 2022

PurposeThe aim of the paper is to analyse the prevalence of corruption in Malaysia since 2004 in relation to political leadership, implementation of anti-corruption measures and the political and business culture based on money politics.Design/methodology/approachThe paper draws from the information and data provided by the Malaysian Anti-Corruption Commission, the Malaysian government, international organisations, media reports, and academic papers.FindingsThe paper analyses the perceived extent of corruption in Malaysia by examining how successive governments have dealt with the problem through a wide range of measures. Corruption remains widespread because of ineffective implementation, a culture of money politics based on mutually beneficial crony associations between political actors and business leaders, political interference to frustrate enforcement against corruption offenders, especially prominent personalities, and the mixed impact of corruption prevention measures. The paper concludes that the political and business culture and the nature of political leadership have eroded the political will to combat grand corruption in Malaysia.Originality/valueThis paper builds on previous research on corruption in Malaysia and highlights the combined negative impact of political leadership and a business and political culture that tolerates and espouses corruption, especially through money politics, and the consequent weak political will for tackling grand corruption.
Formaldehyde gas sensing using metal oxide semiconductor: a brief review
Authors: Ishak Syafiqah , Johari Shazlina , Ramli Muhammad Mahyiddin , Darminto Darminto 
Published: July 2022

Purpose
This review aims to give an overview about zinc oxide (ZnO) based gas sensors and the role of doping in enhancing the gas sensing properties. Gas sensors based on ZnO thin film are preferred for sensing applications because of their modifiable surface morphology, very large surface-to-volume ratio and superior stability due to better crystallinity. The gas detection mechanism involves surface reaction, in which the adsorption of gas molecules on the ZnO thin film affects its conductivity and reduces its electrical properties. One way to enhance the gas sensing properties is by doping ZnO with other elements. A few of the common and previously used dopants include tin (Sn), nickel (Ni) and gallium (Ga).

Design/methodology/approach
In this brief review, previous works on doped-ZnO formaldehyde sensing devices are presented and discussed.

Findings
Most devices provided good sensing performance with low detection limits. The reported operating temperatures were within the range of 200̊C –400̊C. The performance of the gas sensors can be improved by modifying their nanostructures and/or adding dopants.

Originality/value
As of yet, a specific review on formaldehyde gas sensors based on ZnO metal semiconductors has not been done.
Impact of Medicare eligibility on informal caregiving for surgery and stroke
Authors: De Roo Ana C. , Ha Jinkyung , Regenbogen Scott E. , Hoffman Geoffrey J. 
Published: July 2022

AbstractObjectiveTo assess whether the intensity of family and friend care changes after older individuals enroll in Medicare at age 65.Data SourcesHealth and Retirement Study survey data (1998–2018).Study DesignWe compared informal care received by patients hospitalized for stroke, heart surgery, or joint surgery and who were stratified into propensity‐weighted pre‐ and post‐Medicare eligibility cohorts. A regression discontinuity design compared the self‐reported likelihood of any care receipt, weekly hours of overall informal care, and intensity of informal care (hours among those receiving any care) at Medicare eligibility.Data CollectionNot applicable.Principal FindingsA total of 2270 individuals were included; 1674 (73.7%) stroke, 240 (10.6%) heart surgery, and 356 (15.7%) joint surgery patients. Mean (SD) care received was 20.0 (42.1) weekly hours. Of the 1214 (53.5%) patients who received informal care, the mean (SD) care receipt was 37.4 (51.7) weekly hours. Mean (SD) overall weekly care received was 23.4 (45.5), 13.9 (35.8), and 7.8 (21.6) for stroke, heart surgery, and joint surgery patients, respectively. The onset of Medicare eligibility was associated with a 13.6 percentage‐point decrease in the probability of informal care received for stroke patients (p = 0.003) but not in the other acute care cohorts. Men had a 16.8 percentage‐point decrease (p = 0.002) in the probability of any care receipt.ConclusionsMedicare coverage was associated with a substantial decrease in family and friend caregiving use for stroke patients. Informal care may substitute for rather than complement restorative care, given that Medicare is known to expand the use of postacute care. The observed spillover effect of Medicare coverage on informal caregiving has implications for patient function and caregiver burden and should be considered in episode‐based reimbursement models that alter professional rehabilitative care intensity.
A novel circ_0000654/miR‐375/E2F3 ceRNA network in esophageal squamous cell carcinoma
Authors: Luo Chunyu , Zhao Xiaowei , Wang Yuan , Li Yanqiu , Wang Tuo , Li Shumin 
Published: July 2022

AbstractBackgroundThe competing endogenous RNA (ceRNA) activity of circular RNAs (circRNAs) has been implicated in the pathogenesis of cancers, including esophageal squamous cell carcinoma (ESCC). Here, we identified the ceRNA mechanism of circ_0000654 regulation in ESCC.MethodsThe levels of circ_0000654, E2F transcription factor 3 (E2F3), and microRNA (miR)‐375 were gauged by quantitative real‐time PCR (qRT‐PCR) and western blot. Cell proliferation was assessed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTS) and 5‐ethynyl‐2′‐deoxyuridine (EdU) assays. Cell apoptosis was detected by flow cytometry. Cell colony formation was tested by colony formation assay. Dual‐luciferase reporter, RNA pull‐down and RNA immunoprecipitation (RIP) assays were performed to confirm the direct relationship between miR‐375 and circ_0000654 or E2F3. Xenograft model assays were used to evaluate the effect of circ_0000654 in vivo.ResultsCirc_0000654 and E2F3 were upregulated in ESCC. Circ_0000654 depletion enhanced cell apoptosis and hindered cell proliferation and glycolysis in vitro, as well as weakened tumor growth in vivo. Increased expression of E2F3 counteracted the effects of circ_0000654 depletion. Mechanistically, E2F3 was a target of miR‐375, and circ_0000654 modulated E2F3 expression through sequestering miR‐375. Furthermore, miR‐375 upregulation phenocopied circ_0000654 knockdown in inhibiting ESCC progression.ConclusionOur findings identify a new circ_0000654/miR‐375/E2F3 ceRNA crosstalk for the oncogenic role of circ_0000654 in ESCC and establish a notion that targeting circ_0000654 and its pathways may have the potential to improve ESCC outcome.
A retrospective study of the efficacy and safety of naldemedine for opioid‐induced constipation in thoracic cancer patients
Authors: Imai Hisao , Fujita Yukiyoshi , Hiruta Eriko , Masuno Takashi , Yamazaki Shigeki , Tanaka Hajime , Kamiya Teruhiko , Sandoh Mitsuru , Takei Satoshi , Arai Kazuya , Nishiba Hiromi , Mogi Junnosuke , Kaira Kyoichi , Minato Koichi 
Published: July 2022

AbstractBackgroundWe conducted a multicenter, retrospective study on the efficacy and safety of naldemedine in thoracic cancer patients using opioids in clinical practice.MethodsWe retrospectively evaluated thoracic cancer patients treated with naldemedine at 10 institutions in Japan. Clinical data of patients administered naldemedine between June 2017 and August 2019 were extracted from electronic medical records. Inclusion criteria were as follows: (i) patients hospitalized for at least seven days before and after naldemedine administration, and (ii) those whose frequency of defecation was entered in the medical records.ResultsForty patients were analyzed, and defecation frequency was observed for at least seven days before and after naldemedine administration. The response rate was 65.0% (95% CI: 50.2%–79.7%). The number of defecations increased significantly after naldemedine administration in the overall population, as well as among only those who defecated <3 times/week before naldemedine administration, and those that were administered ≥30 mg/day of morphine equivalent. Diarrhea was the most common adverse event in all grades, occurring in 11 patients (27.5%), of which 9 (81.8%) were grade 1 or 2. None of the patients experienced grade 4 or higher adverse events.ConclusionThe efficacy and safety of naldemedine for thoracic cancer patients in clinical practice were comparable with those of prospective studies, which suggest that naldemedine may be effective and feasible for most thoracic cancer patients.
An evaluation of the impacts of the adoption of IFRS 15 Revenue from Contracts with Customers
Authors: Onie Sebastian , Ma Le , Spiropoulos Helen , Wells Peter 
Published: July 2022

AbstractThis paper evaluates the impact of IFRS 15 Revenue from Contracts with Customers on the value relevance of financial reports for Australian listed firms. We find that for most firms the impacts of transition were immaterial, however some firms experienced a significant reduction in earnings and/or retained earnings and for these firms the value relevance of earnings was generally lower in the pre‐adoption period compared to firms in which there was no material impact. Post adoption, there is little evidence that the standard improved the relevance of earnings generally.
Adult smokers’ discussions about vaping with health professionals and subsequent behavior change: a cohort study
Authors: Cho Yoo Jin , Thrasher James F. , Gravely Shannon , Alberg Anthony , Borland Ron , Yong Hua‐Hie , Cummings K. Michael , Hitchman Sara C. , Fong Geoffrey T. 
Published: July 2022

AbstractAimsTo measure the prevalence and changes in smokers’ discussions with health professionals (HPs) about nicotine vaping products (NVPs) and HPs’ recommendations about NVPs between 2016 and 2020, and their associations with tobacco product use transitions.DesignCohort study using multinomial logistic regression analyses on data from waves 1 (2016), 2 (2018) and 3 (2020) from the International Tobacco Control Four Country Smoking and Vaping Surveys.SettingFour countries with varying NVP regulatory environments: ‘most restrictive’ (Australia), ‘somewhat restrictive’ (Canada) and ‘less restrictive’ (England and the United States).ParticipantsAdult exclusive daily smokers who did not report NVP use at the time of their baseline survey and had visited a HP in the last 12–24 months. Prevalence data came from 4125, 4503 and 4277 respondents, respectively, for each year. Longitudinal data were from 4859 respondents who participated in at least two consecutive surveys.MeasurementsPrevalence of self‐reported discussions with HPs and recommendations from HPs about NVPs. Longitudinal transitions from smoking to vaping (either exclusively or concurrently with smoking) and quitting (regardless of NVP uptake).FindingsThe prevalence of NVP discussions was low among countries with varying regulatory environments and study waves (range = 1.4–6.2%). In 2020, a low percentage of smokers who discussed NVPs with a HP reported that their HPs recommended they use NVPs in the United States (14.7%), Australia (20.2%), Canada (25.7%), with a higher percentage in England (55.7%) where clinical guidelines for smoking cessation include NVPs. Compared with 12.0% of smokers who reported no discussion, 37.0% of those whose HPs recommended NVPs transitioned to vaping at follow‐up. Transition to quitting was 9.6% with HPs’ recommendation of NVPs versus 13.5% without discussion, a non‐significant difference.ConclusionsIn Australia, Canada, England and the United States between 2016 and 2020, health professionals’ discussions with smokers about nicotine vaping products (NVPs) were infrequent. NVP discussions were associated with NVP uptake, but not with quitting smoking.
The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high‐grain diet
Authors: Tian Changxin , Wu Jian , Jiao Jinzhen , Zhou Chuanshe , Tan Zhiliang 
Published: July 2022

AbstractLimited knowledge is clarified about alterations in the related expression of nutrient chemosensors in the distal small intestine and hindgut under a high‐grain (HG) diet in small ruminants. Herein, this study was performed to investigate the expression changes related to nutrient sensing and transport in the ileal and colonic epithelium of goats in response to feeding an HG diet. Twelve Liuyang black goats (similar age and weight) were randomly assigned into two groups: an HG diet (concentrate: hay = 90:10) and a CON diet (concentrate: hay = 55:45). Immunohistochemistry was applied to detect morphological changes in the gut epithelium together with altered expression of chemosensors in the ileum and colon. The results showed that feeding an HG diet increased ileal villus height and depth and induced mucosal sloughing in the colon. The expressions of the nutrient transporters GLUT2, GLUT5, SGLT2, CD36, rBAT, EAAT3, and LAT2 and sensing receptors GPR43 and T1R1 were promoted in the ileum under HG conditions. Moreover, feeding an HG diet also enhanced the expression of GLUT2, SGLT2, CD36, and GPR43 in the colon. These findings indicate that adaptation of the gastrointestinal tract to the HG diet promoted the absorption of glucose, fatty acids, and amino acids in goats.
Antimicrobial effects of four chemical additives on fermentation quality, aerobic stability, and in vitro ruminal digestibility of total mixed ration silage prepared with local food by‐products
Authors: Han Zhe , Xu Guofeng , Wang Siran , Dai Tongtong , Dong Dong , Zong Cheng , Yin Xuejing , Jia Yushan , Shao Tao 
Published: July 2022

AbstractThe objective of the work is to evaluate the effects of four chemical additives on fermentation quality, aerobic stability, and in vitro ruminal digestibility of total mixed ration (TMR) silage. TMR containing 15% spent mushroom substrate, 25% soybean sauce residue, 45% napiergrass (Pennisetum purpureum (L.) Schum.), and 15% concentrate was ensiled with the following: (1) no additives (control), (2) potassium sorbate (PS, 0.1%), (3) sodium benzoate (SB, 0.1%), (4) sodium diacetate (SDA, 0.5%), and (5) calcium propionate (CAP, 0.5%) based on fresh weight. All silos (10 L) were opened for fermentation quality, in vitro ruminal digestibility analysis after 60 days of ensiling, and then subjected to aerobic stability test for 9 days. All TMR silages were well‐conserved, as indicated by low pH, butyric acid, and ammonia nitrogen contents. During aerobic exposure, SDA was more stable with higher (p < 0.05) lactic acid and acetic acid contents and lower (p < 0.05) yeast counts than other TMR silages. In addition, SDA significantly (p < 0.05) increased cumulate gas production and in vitro dry matter digestibility compared with the control. Overall, SDA is recommended as additives to improve fermentation quality, in vitro ruminal digestibility, and aerobic stability of TMR silage prepared with local food by‐products.
Acute disseminated encephalomyelitis in an elderly patient following pneumococcal vaccination with extremely high cerebrospinal fluid interleukin‐6
Authors: Kira Yuu‐ichi , Tashiro Takumi , Maeda Norihisa 
Published: July 2022

AbstractBackgroundPostvaccination acute disseminated encephalomyelitis (ADEM) may develop 2–30 days after vaccination. However, ADEM following pneumococcal vaccination has never been reported.Case presentationWe report a 73‐year‐old woman with ADEM following pneumococcal vaccination. She developed acute fever and consciousness disturbance 17 days after the second administration of 23‐valent pneumococcal polysaccharide vaccine (PPSV23). Head magnetic resonance imaging (MRI) revealed numerous T2‐high lesions, mainly involving the cerebral and cerebellar white matter and brainstem. Cerebrospinal fluid examination showed polymorphonuclear pleocytosis and markedly elevated interleukin‐6 (58,400 pg/ml). Her symptoms and MRI lesions were promptly resolved by steroid pulse therapy, with no relapse.ConclusionAlthough PPSV23 is recommended for elderly individuals, this case highlights the risk of ADEM caused by unexpected immune activation following repeated administration of the vaccine.
CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758‐3p/KDM6A axis
Authors: Liao Hongyi , Tu Qingqiang , Kang Yunze , Mao Guping , Li Zhiwen , Hu Shu , Sheng Puyi , Wang Xudong , Xu Yiyang , Long Dianbo , Xu Yuanyuan , Kang Yan , Zhang Ziji 
Published: July 2022

AbstractObjectivesOsteoarthritis (OA) is a degenerative disease causing the progressive destruction of articular cartilage; however, the aetiology has not yet been elucidated. Circular RNAs (circRNAs) are reportedly involved in cartilage degeneration and OA development. In the present study, we identified that circNFIX regulates chondrogenesis and cartilage homeostasis.Materials and MethodsMicroarray analysis was performed to explore circRNA expression during the chondrogenic differentiation of human adipose‐drived stem cells (hADSCs). CircNFIX expression was determined using quantitative reverse transcription‐polymerase chain reaction and in situ hybridization. Gain‐ and loss‐of‐function assays were performed to validate the role of circNFIX in cartilage homeostasis. RNA pull‐down, Argonaute2‐RNA immunoprecipitation and luciferase reporter assays were performed to evaluate the interactions among circNFIX, miR758‐3p and KDM6A.ResultsCircNFIX expression was upregulated in the early and middle stages, whereas downregulated in the late stage of hADSC chondrogenesis. CircNFIX inhibition attenuated hADSC chondrogenesis. CircNFIX was remarkably downregulated in OA samples, circNFIX overexpression protected against chondrocyte degradation and alleviated OA progression in the destabilization of the medial meniscus OA model. Mechanistically, circNFIX acted as a sponge of miR758‐3p and played a role in the chondrogenesis and chondrocyte degeneration by targeting the miR‐758‐3p/KDM6A axis.ConclusionsOur results revealed a key role of circNFIX in chondrogenesis and cartilage homeostasis, which may provide a potential therapeutic strategy for OA treatment.