bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon dioxide and hydrogen adsorption study on surface-modified HKUST-1 with diamine/triamine
Authors: Zelenka Tomas , Simanova Klaudia , Saini Robin , Zelenkova Gabriela , Nehra Satya Pal , Sharma Anshu , Almasi Miroslav 
Published: October 2022

AbstractThe present article intended to study the influence of post-synthetic modification with ethylenediamine (en, diamine) and diethylenetriamine (deta, triamine) within the coordinatively unsaturated sites (CUSs) of HKUST-1 on carbon dioxide and hydrogen storage. The as-sythesized adsorbent was solvent-exchanged and subsequently post-synthetically modified with di-/triamines as sources of amine-based sorption sites due to the increased CO2 storage capacity. It is known that carbon dioxide molecules have a high affinity for amine groups, and moreover, the volume of amine molecules itself reduces the free pore volume in HKUST-1, which is the driving force for increasing the hydrogen storage capacity. Different concentrations of amines were used for modification of HKUST-1, through which materials with different molar ratios of HKUST-1 to amine: 1:0.05; 1:0.1; 1:0.25; 1:0.5; 1:0.75; 1:1; 1:1.5 were synthesized. Adsorption measurements of carbon dioxide at 0 °C up to 1 bar have shown that the compounds can adsorb large amounts of carbon dioxide. In general, deta-modified samples showed higher adsorbed amounts of CO2 compared to en-modified materials, which can be explained by the higher number of amine groups within the deta molecule. With an increasing molar ratio of amines, there was a decrease in wt.% CO2. The maximum storage capacity of CO2 was 22.3 wt.% for HKUST-1: en/1:0.1 and 33.1 wt.% for HKUST-1: deta/1:0.05 at 0 °C and 1 bar. Hydrogen adsorption measurements showed the same trend as carbon dioxide, with the maximum H2 adsorbed amounts being 1.82 wt.% for HKUST-1: en/1:0.1 and 2.28 wt.% for HKUST-1: deta/1:0.05 at − 196 °C and 1 bar.
The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
Authors: Kamimura Hisashi , Matsuoka Takahiro , Okai Hiroshi , Shimizu Naoki , Harada Shu , Matsuo Koji 
Published: October 2022

AbstractSuicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in patients with mood disorders. 11 mood disorder patients with a history of suicide attempt (MDSA), 18 mood disorder patients with no history of suicide attempt (MDNSA), and 17 healthy individuals were studied. The MDSA patients showed significantly high impulsivity and hopeless compared to healthy subjects, great response to the thread word task in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) compared to MDNSA patients, and the significant correlation between the personality traits and brain activation. The MDNSA did not show the trend. The results suggest that the personality traits and the activation of OFC and DLPFC during the negative emotional cognitive stimuli is associated with suicidal behavior, indicating the findings are involved in the pathophysiology of suicidality in mood disorders.
Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1
Authors: Lutz Michael , Schmierer Jordana , Takimoto Toru 
Published: October 2022

AbstractAvian species are the major natural reservoir from which pandemic influenza A viruses can be introduced to humans. Avian influenza A virus genes, including the three viral polymerase genes, PA, PB1 and PB2, require host-adaptive mutations to allow for viral replication and transmission in humans. Previously, PA from the 2009 pH1N1 viral polymerase was found to harbor host-adaptive mutations leading to enhanced viral polymerase activity. By quantifying translation and mRNA transcription, we found that the 2009 pH1N1 PA, and the associated host-adaptive mutations, led to greater translation efficiency. This was due to enhanced cytosolic accumulation of viral mRNA, which was dependent on the host RNA binding protein GRSF1. Mutations to the GRSF1 binding site in viral mRNA, as well as GRSF1 knockdown, reduced cytosolic accumulation and translation efficiency of viral mRNAs. This study identifies a previously unrecognized mechanism by which host-adaptive mutations in PA regulate viral replication and host adaptation. Importantly, these results provide greater insight into the host adaptation process of IAVs and reveal the importance of GRSF1 in the lifecycle of IAV.
Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex
Authors: Chu Yu-Yi , Chen Mei-Kuang , Wei Yongkun , Lee Heng-Huan , Xia Weiya , Wang Ying-Nai , Yam Clinton , Hsu Jennifer L. , Wang Hung-Ling , Chang Wei-Chao , Yamaguchi Hirohito , Jiang Zhou , Liu Chunxiao , Li Ching-Fei , Nie Lei , Chan Li-Chuan , Gao Yuan , Wang Shao-Chun , Liu Jinsong , Westin Shannon N. , Lee Sanghoon , Sood Anil K. , Yang Liuqing , Hortobagyi Gabriel N. , Yu Dihua , Hung Mien-Chie 
Published: October 2022

AbstractPoly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a substantial clinical challenge. In the present study, we report that anaplastic lymphoma kinase (ALK) directly phosphorylates CDK9 at tyrosine-19 to promote homologous recombination (HR) repair and PARP inhibitor resistance. Phospho-CDK9-Tyr19 increases its kinase activity and nuclear localization to stabilize positive transcriptional elongation factor b and activate polymerase II-dependent transcription of HR-repair genes. Conversely, ALK inhibition increases ubiquitination and degradation of CDK9 by Skp2, an E3 ligase. Notably, combination of US Food and Drug Administration-approved ALK and PARP inhibitors markedly reduce tumor growth and improve survival of mice in PARP inhibitor-/platinum-resistant tumor xenograft models. Using human tumor biospecimens, we further demonstrate that phosphorylated ALK (p-ALK) expression is associated with resistance to PARP inhibitors and positively correlated with p-Tyr19-CDK9 expression. Together, our findings support a biomarker-driven, combinatorial treatment strategy involving ALK and PARP inhibitors to induce synthetic lethality in PARP inhibitor-/platinum-resistant tumors with high p-ALK–p-Tyr19-CDK9 expression.
Understanding the critical elements of the pyrocumulonimbus storm sparked by high-intensity wildland fire
Authors: Fromm Michael , Servranckx René , Stocks Brian J. , Peterson David A. 
Published: October 2022

AbstractHigh-intensity wildland fires can produce extreme flaming and smoke emissions that develop into a fire-cloud chimney, reaching into the upper troposphere or lower stratosphere. Termed pyrocumulonimbus, these storms are both conventional and counterintuitive. They have been observed to produce lightning, hail, downdraft wind hazards, and tornadoes as expected with severe convective storms, but counterintuitively, they are not associated with significant precipitation. Pyrocumulonimbus storms have been noticed outside wildfire expert circles following Australia’s Black Summer in 2019/20, and have since repeatedly made headlines in the United States. However, much is unknown about their behavior, energetics, history, and impact on the Earth/atmosphere system. We address several questions and science challenges related to these unknowns. Our worldwide record of pyrocumulonimbus events from 2013 to 2021 shows that the phenomenon is neither new nor rare. Despite high occurrences in 2019 and 2021, these data do not support identification of a trend. Future studies require an expansive record of pyrocumulonimbus occurrence globally and regionally, both historically and continuously forward in time.
Aerosol absorption has an underappreciated role in historical precipitation change
Authors: Samset Bjørn H. 
Published: October 2022

AbstractPrecipitation change has proven notoriously hard to simulate consistently between global climate models. Aerosol induced shortwave absorption over the historical era is also poorly constrained in both observations and modelling. These factors are closely linked, since absorption induced heating of the atmospheric column inhibits precipitation formation. Here I show that the spread in simulated aerosol absorption in the most recent generation of climate models (CMIP6) can be a dominating cause of uncertainty in simulated precipitation change, globally and regionally. Consequently, until improvements are made in scientific understanding of the key absorbing aerosol types, projections of precipitation change under future anthropogenic emissions will have major, irreducible uncertainties. Black carbon, which has recently been found to have only a weak influence on global surface temperature, regains prominence as a contributor to regional precipitation change and its historical and future evolution.
Fundamentals of HDX-MS
Authors: Vinciauskaite Vanesa , Masson Glenn R. 
Published: October 2022

Abstract
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the standard repertoire of techniques used by molecular biologists to investigate protein structure and dynamics. This is partly due to the increased use of automation in all stages of the technique and its versatility of application—many proteins that present challenges with techniques such as X-ray crystallography and cryoelectron microscopy are amenable to investigation with HDX-MS. The present review is aimed at scientists who are curious about the technique, and how it may aid their research. It describes the fundamental basis of solvent exchange, the basics of a standard HDX-MS experiment, as well as highlighting emerging novel experimental advances, which point to where the field is heading.
An Adolescent Confronted With Cluttering: The Story of Johan
Authors: van Zaalen Yvonne , Strangis Dario 
Published: October 2022

Purpose:This case study is presented to inform the reader of potential speech, language, cognitive, and emotional characteristics in preadolescent cluttering.Method:This case study describes a 10-year-old boy who started to clutter during preadolescence. The case illustrates that, in some adolescents, cluttering can co-occur with temporary stuttering-like behavior. In this case, signs of disturbances in speech-language production associated with behavioral impulsiveness as a young child were noted. Speech, language, cognitive, and emotional results of the case are reported in detail.Results:The changes in fluency development are reported and discussed within the context of changes in the adolescent brain as well as adolescent cognitive and emotional development. While being unaware of their speech condition before adolescence, during preadolescence, the changes in brain organization lead to an increase in rate and a decrease in speech control. Given that the client had limited understanding of what was occurring, they were at risk of developing negative communication attitudes. Speech-language therapists are strongly advised to monitor children with cluttering signals in the early years of their adolescence.Supplemental Material:https://doi.org/10.23641/asha.21318072
Assigning a different endoscopist for each annual follow-up may contribute to improved gastric cancer detection rates
Authors: Unno Shuhei , Igarashi Kimihiro , Saito Hiroaki , Hirasawa Dai , Okuzono Toru , Tanaka Yukari , Nakahori Masato , Matsuda Tomoki 
Published: October 2022

Abstract
Background and study aims Esophagogastroduodenoscopy (EGD) is an effective and important diagnostic tool to detect gastric cancer (GC). Although previous studies show that examiner, patient, and instrumental factors influence the detection of GC, we analyzed whether assigning a different examiner to surveillance EGD would improve the detection of GC compared to assigning the same examiner as in the previous endoscopy.
Patients and methods We retrospectively reviewed patients who underwent two or more consecutive surveillance EGDs at a single center between 2017 and 2019. We identified factors associated with GC detection using multivariable regression analysis and propensity-score matching.
Results Among 7794 patients, 99 GC lesions in 93 patients were detected by surveillance EGD (detection rate; 1.2 %), with a mean surveillance interval of 11.2 months. Among the detected 99 lesions, 87 (87.9 %) were curatively treated with endoscopy. There were no differences in the clinicopathologic characteristics of GC detected by the same or different endoscopists. GC detection in the group examined by different endoscopists was more statistically significant than in the group examined by the same endoscopist, even after propensity-score matching (1.6 % and 0.7 %; P < 0.05). Endoscopic experience and other factors were not statistically significant between the two groups.
Conclusions In surveillance EGD, having a different endoscopist for each exam may improve GC detection rates, regardless of the endoscopist’s experience.
Development, Synthesis, and in silico Investigations of Novel Acyclic Allyl Fluoride Derivatives
Authors: Saini Vaneet , Chauhan Nishita , Singh Harjinder , Singh Kamal Nain , McKenna Jeffrey M. 
Published: October 2022

AbstractA one step electrophilic fluorination of alkenes is reported, which furnishes the products in a highly regioselective manner via allylic rearrangement. The reaction proceeds efficiently under mild conditions with the use of trisubstituted alkenes as olefin partner and Selectfluor as an electrophilic fluorinating agent without the need of any transition metal catalyst or pre-functionalized substrates. Virtual screening of the newly synthesized compounds shows their potential application as herbicides by inhibiting protoporphyrinogen oxidase (PPO) enzyme.
Exploration of Copper(II) Acetate Catalyzed Regioselective Ethoxylation of o-Haloanilides with Picolinamide as a Directing Group
Authors: Li Xiaoyi , Qin Dingmei , Mao Zewei , Li Yanping 
Published: October 2022

AbstractAn efficient Cu-catalyzed Ullmann-type C–O coupling of o-haloanilides was developed. This method permits regioselective 2-ethoxylation of N-(2-bromoaryl)- or N-(2-iodoaryl)picolinamides in ethanol with Cu(OAc)2 as a convenient catalyst and with picolinamide as a directing group and intramolecular ligand. The reaction is characterized by good regioselectivity, high yields, and the absence of the need for an additional ligand.
Halodiazirines as Valuable Reagents for the Synthesis of Halocyclo­propanes
Authors: Ollevier Thierry , To Hoang-Minh , Malets Oleksii , Mazur Maryna , Mykhailenko Olha , Kompaniiets Olena 
Published: October 2022

AbstractHalodiazirines have emerged as very useful reagents in photochemically or thermally mediated cyclopropanation reactions with alkenes. This short review highlights the synthetic applications of these reagents as precursors of halocarbenes in transformations with various alkenes.1	Introduction2	Cyclopropanation of Aryl Halodiazirines3	Tandem Reactions Using Aryl Halodiazirines4	Cyclopropanation of Alkyl- and Benzyl-halodiazirines5	Cyclopropanation of Other Halodiazirines6	Reactions of Halodiazirines with Alkynes7	Conclusion and Outlook
Synthesis of 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazoles and Homologs from 5-Substituted 2-(Alkynyl)tetrazoles via Microwave-Induced Intramolecular Nitrile-Imine–Alkyne 1,3-Dipolar Cycloaddition
Authors: Usami Yoshihide , Yoneyama Hiroki , Adachi Mano , Morita Aoshi , Nakagawa Maki , Baba Miho , Yamawaki Kanako , Hayama Noboru , Harusawa Shinya 
Published: October 2022

AbstractMicrowave irradiation of 2-alkynyl-5-(phenyl or alkyl)tetrazoles affords 2-(phenyl or alkyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles via intramolecular [3+2] cyclization of nitrile-imine intermediates. In the present method, the use of 5-alkyltetrazoles as the starting materials is more advantageous because of the difficulties associated with conventional photoreactions. From 2-phenylalkynyl-5-methylthio-1H-tetrazoles, the reaction efficiently produces 2-methylthio-3-phenyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles. The procedure using the methylthio group is applied to the total synthesis of three naturally occurring withasomnines. The method is also extended to the construction of molecules in which bicyclic pyrazoles are fused to six- to eight-membered rings.
Recent Advancements in Bottromycin Biosynthesis
Authors: Mahanta Nilkamal , PH Krushnamurthy , KS Subramanya , Das Simita , G. Dhananjaya 
Published: October 2022

AbstractBottromycin is a structurally complex cyclic peptidic compound isolated from Streptomyces bottropensis and related organisms and belongs to the RiPP family of natural products (ribosomally synthesized and post-translationally modified peptides). It exhibits potent antibacterial properties against gram-positive pathogens (including drug resistant strains such as MRSA, MIC 1 μg/mL and VRE, MIC 0.5 μg/mL) and mycoplasma. Bottromycin blocks the binding of the aminoacyl-tRNA to the A-site on the 50S ribosome and hence inhibits protein synthesis. Bottromycins contain structurally diverse post-translational modifications (PTMs) on a small peptide (GPVVVFDC) including a unique macrocyclic amidine, rare β-methylation, terminal thiazole heterocycle, oxidative decarboxylation, and Asp epimerization, among others. It exhibits a precursor peptide organization with a C-terminal follower peptide and a N-terminal core peptide. There are several new studies reported recently which gave detailed insights into the bottromycin biosynthesis pathway. This Account highlights the current advancements in understanding the biosynthetic pathway of bottromycin focusing mainly on the biochemically and structurally characterized enzymes and intricate details of the peptide–protein biophysical interactions. These studies have provided a strong foundation for conducting combinatorial biosynthesis and synthetic biological studies to create novel bottromycin variants for therapeutic applications.1	Introduction2	Biosynthetic Pathway for Bottromycin3	Enzymology of Bottromycin Biosynthesis3.1	Cleavage of Methionine (BotP)3.2	Radical SAM Methyltransferases (BotRMT1, BotRMT2, BotRMT3)3.3	ATP-Dependent YcaO Enzymes3.3.1	Thiazoline Formation by BotC3.3.2	Macrolactamidine Formation by BotCD3.4	Follower Peptide Hydrolysis (BotAH)3.5	Aspartate Epimerization (BotH)3.6	Oxidative Decarboxylation (BotCYP)3.7	O-Methyltransferase (BotOMT)4	Heterologous Bottromycin Production and Analogue Preparation5	Summary and Outlook
Stereoselective Synthesis of (Z)-1,2-Bis(arylsulfanyl)ethenes with Calcium Carbide as a Solid Alkyne Source
Authors: Li Zheng , Wang Qian , Wang Zhiqiang 
Published: October 2022

AbstractA concise stereoselective synthesis of (Z)-1,2-bis(arylsulfanyl)ethenes by the reaction of arylsulfonyl chlorides with calcium carbide in the presence of cuprous iodide as a catalyst is described. The salient features of this protocol are its use of an inexpensive and easily handled solid alkyne source as a surrogate for flammable and explosive gaseous acetylene, its commercially available starting materials, its high stereoselectivity, and its simple workup procedures. The stereochemical structure of a selected product was determined by single-crystal X-ray diffraction. This method can be extended to a gram scale.
Hospital service for ischemic stroke patients in Brazilian countryside: are we still in the ‘80s?
Authors: Junior Antonio Fernando Ribeiro Silva , Santos Gabriel Calasans dos , Kaneto Carla Martins , Jesus Pedro Antonio Pereira de , Melo Paulo Roberto Santana de 
Published: October 2022

Abstract
Background Stroke is one of the most common causes of death and incapacity in the world. The benefits of reperfusion therapies and hospitalization in neurologic intensive care units (ICUs) are undeniable. However, these treatments are not widely available in a continental-sized country like Brazil.
Objective To describe the treatment for ischemic stroke and the functional outcome 90 days after the hospitalization of patients in the Brazilian countryside.
Methods Observational, prospective case series study design. The data collected refer to randomly selected patients hospitalized in 3 hospitals in the south region of the state of Bahia between December 2018 and December 2019.
Results The population consisted of 61 consecutive patients. They were elderly (median age: 62 years old); with a predominance of hypertension (82%); and were light to moderate stroke cases (National Institute of Health Stroke Scale [NIHSS] median: 7). A total of 37.7% of the cases arrived at the hospital in a < 4.5-hour window but received no reperfusion therapy. Of these, 94.3% were discharged from the hospital with a prescription for antiplatelets or anticoagulant. A total of 64.1% of the patients received a statin prescription. At the end of the follow-up period, the general mortality was 21%. Almost half of the population (47.9%) evolved to an unfavored outcome (modified Rankin scale [mRs]: 3 to 6).
Conclusion Our population presented sociodemographic and comorbidities characteristics similar to those of other national samples. No reperfusion therapy was used and the treatment was basically secondary and prophylaxis-oriented, and almost half of the population evolved with incapacities and a high mortality rate, despite the initial low clinical gravity.
Chronic Obstructive Pulmonary Disease and Small Airways Diseases
Authors: Elicker Brett M. 
Published: October 2022

AbstractThe small airways are a common target of injury within the lungs and may be affected by a wide variety of inhaled, systemic, and other disorders. Imaging is critical in the detection and diagnosis of small airways disease since significant injury may occur prior to pulmonary function tests showing abnormalities. The goal of this article is to describe the typical imaging findings and patterns of small airways diseases. An approach which divides the imaging appearances into four categories (tree-in-bud opacities, poorly defined centrilobular nodules, mosaic attenuation, and emphysema) will provide a framework in which to formulate appropriate and focused differential diagnoses.
A comparison of automated and manual analyses of syntactic complexity in L2 English writing
Authors: Châu Quang Hồng , Bulté Bram 
Published: October 2022

Abstract
Automated tools for syntactic complexity measurement are increasingly used for analyzing various kinds of second
language corpora, even though these tools were originally developed and tested for texts produced by advanced learners. This study
investigates the reliability of automated complexity measurement for beginner and lower-intermediate L2 English data by comparing
manual and automated analyses of a corpus of 80 texts written by Dutch-speaking learners. Our quantitative and qualitative
analyses reveal that the reliability of automated complexity measurement is substantially affected by learner errors, parser
errors, and Tregex pattern undergeneration. We also demonstrate the importance of aligning the definitions of
analytical units between the computational tool and human annotators. In order to enhance the reliability of automated analyses,
it is recommended that certain modifications are made to the system, and non-advanced L2 English data are preprocessed prior to
automated analyses.