bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appraising the nexus between influencers and sustainability‐oriented innovation adoption in affordable housing projects
Authors: Moghayedi Alireza , Awuzie Bankole , Omotayo Temitope , Le Jeune Karen , Massyn Mark 
Published: March 2022

AbstractThe emergence of a plethora of innovative construction methods, materials and technologies in the construction industry has been projected to enhance the effective delivery of sustainable affordable housing. However, a lack of empirical evidence buttressing an extensive analysis of the effect of internal and external influencers on adopting these innovations within the affordable housing context in developing countries persists. This study examines the nexus between company and project characteristics as internal influencers, and challenges as external influencers, on the extent of use of sustainability‐oriented innovations (SOIs), on affordable housing projects. Variables emanating from an extensive literature review were presented in a causal model detailing sustainable, innovative, and affordable housing (SIAH). The model and the inherent causality between the constructs were validated through a survey administered on a population of registered South African home developers. The results of structural equation modelling posit a minimal positive impact of internal influencers and moderate negative effects of external challenges on the extent of use of SOIs by home developers. Also, results highlighted the negative mediating impact of challenges on the relationship between internal influences and the extent of use of SOI in affordable housing projects. The study concludes that the external challenges are the key drivers of adopting innovation in SIAH, and by addressing these challenges, the extent of use will significantly improve. The validated causal model can be used as a framework to enhance SOIs adoption in SIAH.
Facile Synthesis of Monodisperse Pt Nanoparticles on Graphitic Carbon Nitride for High‐Performance Photocatalytic H2 evolution
Authors: Liu Yuan , Gao Manyi , Yang Weiwei , Yu Yongsheng 
Published: March 2022

AbstractGraphitic carbon nitride decorated with appropriate co‐catalysts has attracted widespread attention owing to its excellent photocatalytic H2 evolution activity. Herein, monodisperse Pt nanoparticles are synthesized by a facile method and anchored on graphitic carbon nitride (PCN) via self‐assembly route. Among the different Pt content, the 3 % Pt‐loaded PCN (Pt/PCN3) hybrid reveals highest photocatalytic activity for water splitting with the H2 evolution rate of 2.02 mmol g−1 h−1, about 4 times higher than that of Pt‐PCN by traditional photo‐deposition way. This work provides a new strategy for constructing high‐performance Pt‐based co‐catalysts on PCN to boost its photocatalytic activity.
Promoting the Water‐Reduction Kinetics and Alkali Tolerance of MoNi4 Nanocrystals via a Mo2TiC2Tx Induced Built‐In Electric Field
Authors: Zhao Xiangyuan , Tang Kewei , Lee Carmen , Du Cheng‐Feng , Yu Hong , Wang Xiaomei , Qi Weihong , Ye Qian , Yan Qingyu 
Published: March 2022

AbstractMo‐Ni alloy‐based electrocatalysts are regarded as promising candidates for the hydrogen evolution reaction (HER), despite their vulnerable stability in alkaline solution that hampers further application. Herein, Mo2TiC2Tx MXene, is employed as a support for MoNi4 alloy nanocrystals (NCs) to fabricate a unique nanoflower‐like MoNi4–MXn electrocatalyst. A remarkably strong built‐in electric field is established at the interface of two components, which facilitates the electron transfer from Mo2TiC2Tx to MoNi4. Due to the accumulation of electrons at the MoNi4 sites, the adsorption of the catalytic intermediates and ionic species on MoNi4 is affected consequently. As a result, the MoNi4–MX10 nanohybrid exhibits the lowest overpotential, even lower than 10% Pt/C catalyst at the current density of 10 mA cm−2 in 1 m KOH solution (122.19 vs 129.07 mV, respectively). Furthermore, a lower Tafel slope of 55.88 mV dec−1 is reported as compared to that of the 10% Pt/C (65.64 mV dec−1). Additionally, the MoNi4–MX10 catalyst also displays extraordinary chemical stability in alkaline solution, with an activity loss of only 0.15% per hour over 300 h of operation. This reflects the great potential of using MXene‐based interfacial engineering for the synthesis of a highly efficient and stable electrocatalyst.
Interfaced Ag/Cu nanostructures derived from metal thiolate nanoplates: A highly selective catalyst for electrochemical reduction of CO2 to ethanol
Authors: Abeyweera Sasitha C. , Simukaitis Matas , Wei Qilin , Sun Yugang 
Published: March 2022

AbstractSelective reduction of CO2 into liquid products such as ethanol through electrochemical catalysis is promising in storing renewable energy in more deliverable chemicals and balancing the carbon footprint in the environment. However, the lack of efficient catalysts for electrochemical CO2 reduction reaction (eCO2RR) makes the promise challenging because the formation of C2+ alcohols requires coupling reactions between the shallow reduction intermediates and deep reduction intermediates that are usually difficult to form on uniform catalyst surfaces simultaneously with appropriate transient kinetics. Herein, we report a new strategy for synthesizing bimetallic nanostructures with high densities of interfaced Ag/Cu boundaries, which facilitate the coupling reaction of the high‐oxidation‐number intermediates (CO) formed on the Ag surface and the low‐oxidation‐number intermediates (CHx) formed on the Cu surface. The synthesis relies on the electrochemical reduction of bilayered nanoplates made of silver thiolate and copper thiolate, resulting in Ag/Cu nanostructures exposing Ag surface, Cu surface, and the Ag/Cu interfaced boundaries. Balancing the accessible surface areas of the Ag surface, Cu surface, and Ag/Cu boundaries is beneficial for maximizing the activity and selectivity of eCO2RR towards ethanol production. Faradaic efficiency of forming ethanol has been observed as high as about 50% using the Ag/Cu nanostructure catalyst with molar ratio nAg:nCu of 1:1. Moreover, the promoted coupling reaction at the Ag/Cu boundaries and surface modification with thiolate anions significantly suppress the undesirable hydrogen evolution reaction, particularly at high cathodic potentials, maintaining high energy efficiency for eCO2RR.
Disruptions, systems and individual agents—Exploring the intersections
Authors: Mackay Jonathon , Pepper Matthew , Munoz Albert 
Published: March 2022

AbstractOpen systems possess a dilemma whereby they both depend upon‐and are subject to disruptions arising from‐their exogenous environments. Organisations display this dilemma through the need to both manage the inbound flow of supply from upstream nodes and outputs towards downstream customers, whilst also managing issues arising from interactions with these other systems. At the centre of this dilemma sits individual agents, whether they be managers of organisations, business‐level functions or customer‐facing roles. This paper explores how individuals perceive and react towards disruptions and the wider, systemic implications of their actions. This article uses interviews with individuals based on a theoretical framework incorporating general systems theory (GST) and a series of decision theories (namely Protection Motivation Theory) to highlight the commonalities across various actions and strategies that individuals can undertake to address disruptions.
Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
Authors: Zhang Xiqian , Long Fangyi , Li Ruina , Yang Yujie , Wang Ting , He Qin , Xu Min , Wang Ling , Jiang Xuehua 
Published: March 2022

AbstractIt's known that APAP overdose often leads to hepatotoxicity and nephrotoxicity. In the present study, we investigated the preventative effect of Tan IIA on APAP‐induced nephrotoxicity. Mice were orally administrated with Tan IIA (10 or 30 mg/kg/day) for 1 week and subsequently gavaged with 200 mg/kg of APAP. Tan IIA reduced APAP‐induced nephrotoxicity as evidenced by histopathological evaluation and serum creatinine levels. Tan IIA pretreatment promoted the efflux of the toxic intermediate metabolite N‐acetyl‐p‐benzoquinone imine (NAPQI), thus reduced its injury to mouse kidney. After Tan IIA pretreatment, a remarkable increase in mRNA and protein expression of Nrf2 and its target genes Mrp2 and Mrp4 was observed in Nrf2+/+ mice kidneys, however, no obvious change of Mrp2 and Mrp4 mRNA and protein expression was detected in Nrf2−/− mice kidneys. HK‐2 cells were used for exploring the roles of Tan IIA in the Nrf2‐MRPs pathway in vitro. Consistently, Tan IIA up‐regulated the Nrf2‐MRPs pathway and promoted the nuclear Nrf2 accumulation in HK‐2 cells. Collectively, our findings suggested that Tan IIA facilitated the clearance of toxic intermediate metabolite NAPQI from the kidney through upregulation of the Nrf2‐MRP2/4 pathway, thereby, performing preventive effects against APAP‐induced nephrotoxicity.
Vaginal foreign bodies in six nonhuman primates with underlying pathological conditions
Authors: Lamglait Benjamin , Moresco Anneke , Couture Émilie L. , Ferrell Shannon T. , Lair Stéphane 
Published: March 2022

AbstractFour female Japanese macaques (Macaca fuscata) from the same group as well as Wolf's guenon (Cercopithecus wolfi) and a Western lowland gorilla (Gorilla gorilla gorilla) from a second institution presented with vaginal foreign bodies in parallel with diseases of the urogenital tract or with endocrine disorders. These foreign bodies were associated with a mild to marked, diffuse vaginitis in all cases. Underlying pathological conditions consisted of a cavernous uterine hemangioma in a 20‐year‐old macaque, diffuse endometritis in a 21‐year‐old macaque, an in situ endometrial carcinoma in a 24‐year‐old macaque, endometritis and an ovarian cyst‐like structure in the 27‐year‐old Western lowland gorilla, chronic cystitis and chronic renal disease in a 24‐year‐old macaque, and a history of hypothyroidism with irregular reproductive cycles in the 12‐year‐old Wolf's guenon. Vaginal foreign bodies have been reported in nonhuman primates used in biomedical research, but their concurrence with underlying conditions has not been explored. In women, vaginal foreign bodies have been linked to serious underlying medical conditions. This case series emphasizes the recommendation to investigate this abnormal behavior for underlying medical or adverse psychosocial conditions in primates under human care.
The Impact of a Fantasy
Authors: Strand Roger 
Published: March 2022

AbstractPersonalized medicine is a sociotechnical imaginary: a collective vision for the coproduction of a future science, technology and society. This vision has long historical roots but is also the result of a specific context with ongoing changes in society, including the political economy of science. Part of this vision is a fantasy that runs counter to current scientific understanding of illness and disease. One may argue against such fantasies by appealing to facts. Such arguments tend to prove ineffective. If we can explain why they are ineffective this might shed light on possible implications of this state of affair. In this chapter, I draw on Rayner’s concept of “socially constructed ignorance” to indicate the non-modern character of the beliefs in fantasies of personalized medicine, while at the same time personalized medicine is yet another attempt to realize the Cartesian dream. Antonio Gramsci (Lettere dal carcere. Torino: Einaudi. English edition: Gramsci, A. 2011. Prison notebooks, Vol. I. Columbia University Press, New York, 1947) famously wrote: “The crisis consists precisely in the fact that the old is dying and the new cannot be born; in this interregnum a great variety of morbid symptoms appear.” Is the Cartesian dream coming to its end, with personalized medicine as a morbid symptom, a reductio ad absurdum? If so, what it the new that cannot be born?
Efficacy and Safety of Teriparatide in Beta-Thalassemia Major Associated Osteoporosis: A Real-Life Experience
Authors: Gagliardi Irene , Celico Mariella , Gamberini Maria Rita , Pontrelli Margherita , Fortini Monica , Carnevale Aldo , Napoli Nicola , Zatelli Maria Chiara , Ambrosio Maria Rosaria 
Published: March 2022

AbstractOsteoporosis represents a relevant cause of morbidity in adult Thalassemia Major (TM) population. Antiresorptive drugs such as bisphosphonates were demonstrated effective in preventing bone loss. Teriparatide (TP) is an anabolic agent approved for osteoporosis management in the general population, but its use has been very limited in TM patients so far. We evaluated TP efficacy and safety in TM-associated osteoporosis in real-life clinical practice. Retrospective evaluation of 11 TM patients (6 males, 5 females; mean age = 45 ± 4.38 years) with severe osteoporosis and multiple fractures under TP treatment. Mean TP treatment duration was 19 ± 7 months. TP withdrawal was due to poor compliance and side effects (fever and osteo-muscular pain) in two and three patients, respectively. After 12 and 24 months, BMD significantly increased at lumbar (+ 19% and 22%) and femoral sites (+ 13% and 13%). Osteocalcin and cross-laps levels increased after 12 and 24 months (+ 225 and + 54.2%; + 159 and 141%, respectively). No new fractures were detected during TP treatment. Baseline VAS score values (3 ± 3) did not significantly change after 12 and 24 months (3 ± 3 and 2 ± 3, respectively). Five out of eleven patients developed side effects. TP might be an effective treatment for TM-associated osteoporosis since it improves BMD, especially at the lumbar spine, and prevents fragility fractures. TM patients may have a higher frequency of side effects, especially muscle and bone pain under TP treatment, as compared to no TM population. Further studies are needed.
Epigenetische Veränderungen am Promotor des fragilen Histidin-Trias(FHIT)-Gens in menschlichen Sebozyten unter dem Einfluss der In-vitro-Kultur
Authors: Jotzo Magdalena , Zouboulis Christos C. , Ballhausen Wolfgang G. 
Published: March 2022

Zusammenfassung
Hintergrund
Fehlt die Tumorsuppressorfunktion des fragilen Histidin-Trias(FHIT)-Genprodukts, so können Talgdrüsenkarzinome entstehen.

Fragestellung
Am Modell der Sebozytenlinie SZ95 sollten methylierte CpG-Inseln am 5′-Ende des FHIT-Gens identifiziert, die Abnahme der Genexpression und die Zunahme von DNA-Doppelstrang(ds)-Brüchen untersucht werden.

Material und Methoden
Methylierungs‑, Immunfluoreszenzanalysen, Promotorsequenzierung sowie Behandlung der SZ95-Zellen mit 5‑Azacytidin/Trichostatin A (TSA).

Ergebnisse
Die Kultivierung der Sebozyten verlief mit einer zunehmenden Methylierung der CpGs, einer Abnahme der FHIT-Genexpression sowie Anhäufung von DNA-ds-Brüchen. Die Behandlung mit 5‑Azacytidin/TSA zeigte eine Abnahme der DNA-Methylierung sowie Re-Expression von FHIT-Transkripten.

Diskussion
Durch In-vitro-Zellkultur werden epigenetische Veränderungen im zellulären Genom hervorgerufen. Es folgt eine positive Selektion von Sebozyten mit epigenetischer Inaktivierung des FHIT-Genorts.
Assessing life-space mobility
Authors: Ullrich Phoebe , Werner Christian , Abel Bastian , Hummel Merit , Bauer Jürgen M. , Hauer Klaus 
Published: March 2022

Abstract
Background
Life-space mobility (LSM), as the extent of mobility within one’s environment, is a key for successful aging and has become a relevant concept in gerontology and geriatric research. Adequate assessment instruments are needed to identify older persons with LSM restrictions, and to initiate, adapt or evaluate intervention strategies.

Objective
To systematically identify, describe and analyze the psychometric properties of LSM questionnaires, with a special focus on their availability in the German language.

Methods
A systematic literature search was conducted in PubMed, PsycINFO, Cochrane Library, CINAHL, and Web of Science. Studies that examined at least one psychometric property of LSM questionnaires published up to August 2021 were included and evaluated based on the consensus-based standards for the selection of health measurement instruments (COSMIN) guidelines.

Results
This study included 37 validation studies describing 13 different LSM questionnaires. Methodological quality and comprehensiveness of validations were heterogeneous. Based on comprehensive and high-quality results, four LSM questionnaires stood out: the University of Alabama at Birmingham life-space assessment (UAB-LSA), life-space assessment in persons with cognitive impairment (LSA-CI), interview-based and proxy-based versions of the life-space assessment in institutionalized settings (LSA-IS), all of them available in the German language.

Conclusion
This systematic review provides a concise overview of available LSM questionnaires and their psychometric properties to facilitate the selection for use in clinical practice and research. The UAB-LSA and LSA-CI for community settings and the interview-based or proxy-based LSA-IS for institutional settings were found to be the most appropriate LSM questionnaires.
Effectiveness of an Online Programme to Tackle Individual’s Meat Intake through SElf-regulation (OPTIMISE): A randomised controlled trial
Authors: Frie Kerstin , Stewart Cristina , Piernas Carmen , Cook Brian , Jebb Susan A. 
Published: March 2022

Abstract
Purpose
A reduction in meat intake is recommended to meet health and environmental sustainability goals. This study aimed to evaluate the effectiveness of an online self-regulation intervention to reduce meat consumption.

Methods
One hundred and fifty one adult meat eaters were randomised 1:1 to a multi-component self-regulation intervention or an information-only control. The study lasted 9 weeks (1-week self-monitoring; 4-week active intervention; and 4-week maintenance phase). The intervention included goal-setting, self-monitoring, action-planning, and health and environmental feedback. Meat intake was estimated through daily questionnaires in weeks 1, 5 and 9. The primary outcome was change in meat consumption from baseline to five weeks. Secondary outcomes included change from baseline to nine weeks and change in red and processed meat intake. We used linear regression models to assess the effectiveness of all the above outcomes.

Results
Across the whole sample, meat intake was 226 g/day at baseline, 118 g/day at five weeks, and 114 g/day at nine weeks. At five weeks, the intervention led to a 40 g/day (95%CI − 11.6,− 67.5, P = 0.006) reduction in meat intake, including a 35 g/day (95%CI − 7.7, − 61.7, P = 0.012) reduction in red and processed meat, relative to control. There were no significant differences in meat reduction after the four-week maintenance phase (− 12 g/day intervention vs control, 95% CI 19.1, − 43.4, P = 0.443). Participants said the intervention was informative and eye-opening.

Conclusion
The intervention was popular among participants and helped achieve initial reductions in meat intake, but the longer-term reductions did not exceed control.

Trial registration
ClinicalTrials.gov NCT04961216, 14th July 2021, retrospectively registered.
In-situ Raman spectroscopic analysis of dissolved silica structures in Na2CO3 and NaOH solutions at high pressure and temperature
Authors: Takahashi Naoko , Tsujimori Tatsuki , Kamada Seiji , Nakamura Michihiko 
Published: March 2022

AbstractThe dissolved silica structures in quartz-saturated 0.50 and 1.50 m [mol kg H2O–1] Na2CO3 and 0.47 m NaOH solutions at up to 750 °C and 1.5 GPa were investigated by in-situ Raman spectroscopy using a Bassett-type hydrothermal diamond anvil cell. The solubility of quartz in the solutions was determined by in-situ observations of the complete dissolution of the grain. The Raman spectra of the quartz-saturated Na2CO3 and NaOH solutions at high pressures and temperatures exhibited the tetrahedral symmetric stretching band of silica monomers. The lower frequency and broader width of the band than those in pure H2O indicated the presence of both neutral and deprotonated monomers. In addition, we newly confirmed the intense bridging oxygen band and the tetrahedral symmetric stretching band of Q1 (silicate center having a single bridging oxygen atom) in the spectra of the Na2CO3 solutions. The integrated intensity ratios of the bridging oxygen band to the monomer band increased with the addition of Na2CO3 and NaOH to fluids, corresponding to an elevation of the measured quartz solubilities. These observations indicate that the formation of silica oligomers in addition to neutral and deprotonated monomers explains the high dissolved silica concentrations in the solutions. The presence of deprotonated monomers under the experimental conditions suggests that deprotonated oligomers exist in the solutions, because the production of the latter more significantly reduces the Gibbs free energy. The anionic silica species and oligomers formed in alkaline silicate fluids may act as effective ligands for certain metal ions or complexes in deep subduction zones.
Behavioral response to heat stress of twig-nesting canopy ants
Authors: Bujan Jelena , Yanoviak Stephen P. 
Published: March 2022

AbstractTropical forests experience a relatively stable climate, but are not thermally uniform. The tropical forest canopy is hotter and thermally more variable than the understory. Heat stress in the canopy is expected to increase with global warming, potentially threatening its inhabitants. Here, we assess the impact of heating on the most abundant tropical canopy arthropods—ants. While foragers can escape hot branches, brood and workers inside twig nests might be unable to avoid heat stress. We examined nest choice and absconding behavior—nest evacuation in response to heat stress—of four common twig-nesting ant genera. We found that genera nesting almost exclusively in the canopy occupy smaller cavities compared toCamponotusandCrematogasterthat nest across all forest strata.Crematogasterants absconded at the lowest temperatures in heating experiments with both natural and artificial nests.Cephalotes workers were overall less likely to abscond from their nests. This is the first test of behavioral thermoregulation in tropical forest canopy ants, and it highlights different strategies and sensitivities to heat stress. Behavioral avoidance is the first line of defense against heat stress and will be crucial for small ectotherms facing increasing regional and local temperatures.