bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urgensi Keabsahan Status Nasab Anak Yang Lahir Diluar Nikah Pasca Putusan Mahkamah Konstitusi No. 46/PUU – VIII/2010 Perspektif Hukum Perdata Islam
Authors: Muslimah Andi , Rusdiawan Rusdiawan 
Published: April 2022

The purpose of the study was to determine the validity of the status of the child who was born outside of marriage after the decision of the Constitutional Court No. 46 / PUU - VIII / 2010, perspective of Islamic Civil Law and To find out the impact of the civil relationship of children born outside of marriage after the decision of the Constitutional Court No. 46 / PUU - VIII / 2010, perspective of Islamic Civil Law. From the results of the study, the validity of the status of the child born outside the marriage after the decision of the Constitutional Court No. 46 / PUU - VIII / 2010, only constitutes general legal rules (lex generalis) in regulating the status and position of children. Meanwhile, there are other rules that are more specific in nature (lex specialis) such as the Civil Code and the Law on Religious Courts which are complemented by Compilation of Islamic Law. at least two important points can be taken from the decision of the Constitutional Court. First, the civil relations in the above decisions have nothing to do with nasab. Secondly, it relates to the purpose of protecting the rights of children. As for the impact of the existence of a child relationship after the decision of the Constitutional Court depends on the legality of the marriage of both parents. Both legally and legally valid by law have a civil relationship in terms of; nasab, livelihood, inheritance rights, and guardianship. However, children born of zina will only have a civil relationship with their father in terms of maintenance, protection, living. But it is not related to nasab relations, inheritance rights, or guardianship.
Keywords: Decision of the Constitutional Court No. 46 / PUU - VIII / 2010
Analisis Kriteria Cacat Badan Dan Sakit Sebagai Alasan Poligami Dalam Undang-Undang No.1 Tahun 1974 Tentang Perkawinan Menurut Perspektif Hukum Islam
Authors: Dermawansyah Dermawansyah , Yaman Yaman 
Published: April 2022

This study aims to determine the criteria for disability and illness as the reason for polygamy in Law No.1 of 1974 concerning Marriage and aims to find out the views of Islamic law regarding the criteria for disability and illness as reasons for polygamy. To find out the answers to the subject matter, the author uses field research methods that are field and supported by library research (library research) through data collection carried out through interviews (interviews) and documentation with informants directly. The results showed that the reasons for the criteria for disability and illness as reasons for polygamy in Law No.1 of 1974 concerning Marriage and in the view of Islamic law were all bodily disabilities and physical or spiritual illnesses that could make the wife unable to carry out her obligations as a wife to her husband , whether it is deformity or pain that is difficult to cure or permanent that cannot be cured. So that polygamy is the best solution for husbands whose wives experience these things.
Keywords: Analysis of Criteria for Body Disability, Pain as a Reason for Polygamy, Law No.1 of 1974, and Perspective of Islamic Law
Pendekatan Sosiologi dan Antropologi Tentang Poligami
Authors: Raziq Abd , Faturrahman Faturrahman 
Published: April 2022

Masalah poligami selalu hangat dan menjadi pembicaraan bagi kaum pria atau wanita, yang mendukung atau yang menentang, dari yang berkeinginan sampai yang berangan-angan. Bagi kaum pria selalu menjadi trend pembicaraan di antara sesama sebagai sesuatu asyik dibicarakan, sebaliknya bagi kaum wanita,Mengingat masalah poligami ini suatu hal yangpenting di bahas dari sudut pandang sosiologi dan antropologi, dilihat dari segi struktur dan fungsi keluarga. Bagaimana poligami ini di praktekan oleh orang-orang terdahulu sampaidatangnya ajaran Islam mengaturnya, bagaimana masyarakat menyikapinya dan dampak yang timbul oleh pelaksana poligami. Tujuan penelitian ini adalah mendapatkan gambaranumum mengenai pelaksanaan praktek poligami guna memberi pencerahan kepada masyarakat terutama yang menentang praktek syariat Islam.Penelitian ini menggunakan pendekatan kualitatif dan metode kepustakaan. Mengkaji berbagai literatur kepustakaan yang membahas dan mengkaji tentang topik-topik yang ada di jurnal-jurnal atau berita-berita yang factual yang berhubungan dengan makalah. Hasil penelitian menunjukan pada dasarnya praktik poligami sudah ada sejak dahulu sebelum Islam datang, tanpa batashitungan tanpa aturan, datang Islam dan membenahinya, dibatasi poligami dan dicukupkan empat saja. Sikap masyarakat menyikapi poligami sangat beragam umumnya memandangpositif bila dilakasanakan dengan teratur terstruktur dan fungsi keluarga belangsung normal membawa kesejahteraan keluarga. Dampak dari adanya poligami yang tidak dapatmelaksanakan struktur dan fungsi keluarga dengan baik menimbulkan sikap antipati dan cemoohan kepada pelaku poligami, terutama dari kalangan kaum wanita. Poligami hanyaakan menimbulkan kedzaliman dan kesusahan dalam melaksanakan struktur dan fungsi keluarga di antara mereka dan akan sulit untuk berbuat adil.
Keywords: Poligami, Struktur dan Fungsi Keluarga, Syariat Islam
Analisis Pertanggungjawaban Developer terhadap Kredit Macet Menurut Undang-Undang Nomor 1 Tahun 2011 Tentang Perumahan dan Kawasan Permukiman
Authors: Razy Lorinza Hartomo 
Published: April 2022

The development of housing loans disbursed by North Lampung Matrix Housing Developers sometimes results in problems of bad credit where the realization of loans disbursed does not reach the set target. This can affect the activities of the North Lampung Matrix Housing and have implications for Developer accountability. How is the accountability of the developer to credit according to Act Number 1 of 2011 concerning Housing and Settlement Areas in Matrix Housing in North Lampung,. The results of the research show that the responsibility of the developer for credit according to Act Number 1 of 2011 concerning Housing and Settlement Areas in Matrix Housing in North Lampung, which has obligations in billing of debtors who experience non-performing loans in cooperation with the North Lampung Matrix Housing Partner Bank, this obligation is the essence has not been specifically regulated in the banking Act and still uses general rules such as the Banking Act, Civil Code and Act Number 40 of 2007 concerning Limited Liability Companies. The absence of special rules "lex speciali" is a weakness in liability in the event of bad credit. All components of the North Lampung Matrix Housing have juridical responsibility for all operational activities. Efforts to settle non-performing loans in Matrix Housing in North Lampung can be taken in two ways, namely litigation efforts through the court and non-litigation efforts through preventive measures, namely actions to anticipate the emergence of bad loans, early warnings, and negotiation efforts
Keywords: Responsibility, Developer, Housing Loans
Psikologi Humanistik Abraham Maslow
Authors: ‘Adziima Mavatih Fauzul 
Published: April 2022

Psikologi Humanistik biasa disebut dengan psikologi kemanusiaan adalah suatu pendekatan yang menerapkan dengan pengalaman tingkah laku manusia, yang memusatkan pada aktualisasi diri dari seorang manusia. Dalam tulisan ini juga membahas salah satu dari pakar psikologi humanistik yaitu Abraham maslow. Dalam tulisan ini juga disebutkan kelebihan dari psikologi humanistik misalnya Pembelajaran dengan teori ini sangat cocok diterapkan untuk materi-materi pembelajaran yang bersifat pembentukan kepribadian, dan contoh dari kelemahan psikologi humanistik yaitu Siswa yang tidak mau memahami potensi dirinya akan ketinggalan dalam proses belajar. Psikologi humanistik juga memberikan sumbangsihnya bagi pendidikan alternatif yang dikenal dengan sebutan pendidikan humanistik (humanistic education). Pendidikan Humanistik mengupayakan agar keseluruhan individu berusaha mengembangkan potensi yang ada pada dirinya keseluruhan melalui pembelajaran nyata. Pengembangan aspek emosional, sosial, mental, dan keterampilan dalam berkarier menjadi fokus dalam model pendidikan humanistic.
Kata Kunci: Psikologi Humanistik, Abraham Maslow, Psikologi Kemanusiaan
Hukum Menghadiri Digital Wedding Invitation (Interpretasi Hadist Ahkam)
Authors: Farhanah Nida , Asshiddiqy Muhammad Iqbal 
Published: April 2022

Artikel ini mengkaji tentang persoalan hukum menghadiri digital wedding invitation (interpretasi hadis Ahkam kewajiban memenuhi undangan). Masalah utama yang dibahas adalah mengenai tren Digital Wedding Invitation atau undangan pernikahan digital sebagai media dalam menyebarkan berita pernikahan yang tidak dapat dipungkiri merupakan hasil dari arus globalisasi serta kemajuan teknologi dan informasi. Oleh karena itu umat Muslim tidak boleh menerima ataupun menolak begitu saja perubahan-perubahan yang ada akan tetapi perlu menyaringnya agar dapat mengambil kebaikan dan menjauhi kerusakan. Pada zaman Rasulullah undangan walimatul ‘ursy hanyalah disampaikan secara lisan ke lisan. Kemudian undangan pernikahan berkembang kembali dengan undangan yang dicetak serta pada prosesnya banyak mengalami pergeseran fungsi seperti penambahan ayat suci al-Qur’an, dan dicetak secara berlebihan sehingga berpotensi dalam pencemaran lingkungan serta berserakannya ayat suci al-Qur’an. Digital wedding invitation mampu meminimalisir dampak dari undangan pernikahan tertulis atau konvensional sehingga tentunya tidak bijak jika digital wedding invitation ditolak begitu saja dalam kehidupan masyarakat karena pada prakteknya digital wedding invitation tetap memelihara tradisi budaya mengundang orang dalam resepsi pernikahan serta memiliki nilai kemaslahatan yakni dalam hal meminimalisir dampak dari undangan pernikahan konvensional. Akan tetapi perlu diperhatikan pula tata cara penggunaannya demi tercapainya nilai kemaslahatan tersebut.
Kata Kunci: Hadist Ahkam, Hukum Menghadiri Nikah, Kewajiban Memenuhi Undangan
A Novel Approach for Non-Invasive Continuous In-Line Control of Perfusion Cell Cultivations by Raman Spectroscopy
Authors: Graf A. , Lemke J. , Schulze M. , Soeldner R. , Rebner K. , Hoehse M. , Matuszczyk J. 
Published: April 2022

Continuous manufacturing is becoming more important in the biopharmaceutical industry. This processing strategy is favorable, as it is more efficient, flexible, and has the potential to produce higher and more consistent product quality. At the same time, it faces some challenges, especially in cell culture. As a steady state has to be maintained over a prolonged time, it is unavoidable to implement advanced process analytical technologies to control the relevant process parameters in a fast and precise manner. One such analytical technology is Raman spectroscopy, which has proven its advantages for process monitoring and control mostly in (fed-) batch cultivations. In this study, an in-line flow cell for Raman spectroscopy is included in the cell-free harvest stream of a perfusion process. Quantitative models for glucose and lactate were generated based on five cultivations originating from varying bioreactor scales. After successfully validating the glucose model (Root Mean Square Error of Prediction (RMSEP) of ∼0.2 g/L), it was employed for control of an external glucose feed in cultivation with a glucose-free perfusion medium. The generated model was successfully applied to perform process control at 4 g/L and 1.5 g/L glucose over several days, respectively, with variability of ±0.4 g/L. The results demonstrate the high potential of Raman spectroscopy for advanced process monitoring and control of a perfusion process with a bioreactor and scale-independent measurement method.
Echocardiographic Normal Reference Ranges for Non-invasive Myocardial Work Parameters in Pediatric Age: Results From an International Multi-Center Study
Authors: Sabatino Jolanda , Leo Isabella , Strangio Antonio , Bella Sabrina La , Borrelli Nunzia , Avesani Martina , Josen Manjit , Paredes Josefa , Piccinelli Enrico , Sirico Domenico , Pergola Valeria , Fraisse Alain , De Rosa Salvatore , Indolfi Ciro , Di Salvo Giovanni 
Published: April 2022

AimsThis international multi-center study aimed to demonstrate the feasibility and reliability of non-invasive myocardial work (MW) parameters in the pediatric population, and to provide normal reference ranges for this useful echocardiographic tool in this specific subset of patients.Methods and ResultsIn this retrospective multi-center study involving three pediatric laboratories, 150 healthy children and adolescents (mean age of 10.6 ± 4.5, 91 males) were enrolled. A complete echocardiographic examination has been performed, including global longitudinal strain (GLS) assessment. The following parameters of non-invasive MW have been obtained through a dedicated software: global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE), using left ventricular (LV) strain loops and non-invasive brachial artery cuff pressure values. The lowest expected values were for GWI 1,723 mmHg% in males and 1,682 mmHg% in females, for GCW 2,089 and 2,106 mmHg%, for GWE 95.9 and 95.5% whereas the highest expected value for GWW was 78 mmHg% in men and 90 mmHg% in women. The univariable and multivariable analysis showed significant associations between either GWI or GCW with SBP (β coefficient = 0.446, p &lt; 0.001; β coefficient = 0.456, p &lt; 0.001, respectively) and LV GLS (β coefficient = −0.268, p = 0.001; β coefficient = −0.233, p = 0.003, respectively). Inter- and intra-observer variability showed good reproducibility of non-invasive MW parameters.ConclusionNon-invasive MW parameters were feasible and reliable in the pediatric population. This study provided normal reference ranges of these useful echocardiographic indices.
Regional Fat Distributions Are Associated With Subclinical Right Ventricular Dysfunction in Adults With Uncomplicated Obesity
Authors: Liu Jing , Li Jing , Yu Jianqun , Xia Chunchao , Pu Huaxia , He Wenzhang , Li Xue , Zhou Xiaoyue , Tong Nanwei , Peng Liqing 
Published: April 2022

ObjectiveObesity is a prominent public health problem that has increased cardiovascular mortality risks. However, the specific effects of obesity, independent of comorbidities, on cardiac structure and function have not been well clarified, especially those effects on the right ventricle (RV). Cardiovascular magnetic resonance (CMR) tissue tracking can assess detailed RV mechanical features. This study aimed to evaluate RV strain using CMR in uncomplicated obese adults and assess its association with fat distributions.MethodsA total of 49 obese patients and 30 healthy controls were included. The RV global systolic function and strain parameters based on CMR were assessed. Body fat distributions were measured with dual X-ray absorptiometry. RV function indices of obese patients were compared with those of healthy controls. Correlations among related body fat distribution parameters and RV function indices were conducted with multivariable linear regression.ResultsCompared with healthy controls, the obese group had impaired RV strain with lower global longitudinal peak strain (PS), longitudinal peak systolic strain rate (PSSR), circumferential and longitudinal peak diastolic strain rates (PDSR) (all P &lt; 0.05), while LV and RV ejection fractions were not significantly different between the two groups (P &gt; 0.05). Multivariable linear regression analysis demonstrated that android fat% was independently associated with longitudinal PS (β = −0.468, model R2 = 0.219), longitudinal PDSR (β = −0.487, model R2 = 0.237), and circumferential PSSR (β = −0.293, model R2 = 0.086). Trunk fat% was independently associated with longitudinal PSSR (β = −0.457, model R2 = 0.209). In addition, the strongest correlations of circumferential PDSR were BMI and gynoid fat% (β = −0.278, β = 0.369, model R2 = 0.324).ConclusionsExtensive subclinical RV dysfunction is found in uncomplicated obese adults. BMI, as an index of overall obesity, is independently associated with subclinical RV dysfunction. In addition, central obesity (android fat and trunk fat distributions) has a negative effect on subclinical RV function, while peripheral obesity (gynoid fat distribution) may have a positive effect on it.Clinical Trials RegistrationEffect of lifestyle intervention on metabolism of obese patients based on smart phone software (ChiCTR1900026476).
Feasibility of an Automatic Ultrasonographic Image Acquisition System Associated With an Artificial Intelligence Algorithm for Real-Time Monitoring of Cardiac Motion During Cardiac Radio-Ablation
Authors: Casula Matteo , Dusi Veronica , Camps Saskia , Gringet Jérémie , Benoit Tristan , Garonna Adriano , Rordorf Roberto 
Published: April 2022

BackgroundThe management of the cardio-respiratory motion of the target and the reduction of the uncertainties related to patient's positioning are two of the main challenges that stereotactic arrhythmia radio-ablation (STAR) has to overcome. A prototype of a system was developed that can automatically acquire and interpret echocardiographic images using an artificial intelligence (AI) algorithm to calculate cardiac displacement in real-time.MethodsWe conducted a single center study enrolling consecutive patients with a history of ventricular arrhythmias (VA) in order to evaluate the feasibility of this automatic acquisition system. Echocardiographic images were automatically acquired from the parasternal and apical views with a dedicated probe. The system was designed to hold the probe fixed to the chest in the supine position during both free-breathing and short expiratory breath-hold sequences, to simulate STAR treatment. The primary endpoint was the percentage of patients reaching a score ≥2 in a multi-parametric assessment evaluating the quality of automatically acquired images. Moreover, we investigated the potential impact of clinical and demographic characteristics on achieving the primary endpoint.ResultsWe enrolled 24 patients (63 ± 14 years, 21% females). All of them had a history of VA and 21 (88%) had an ICD. Eight patients (33%) had coronary artery disease, 12 (50%) had non-ischemic cardiomyopathy, and 3 had idiopathic VA. Parasternal, as well as apical images were obtained from all patients except from one, in whom parasternal view could not be collected due to the patient's inability to maintain the supine position. The primary endpoint was achieved in 23 patients (96%) for the apical view, in 20 patients (87%) for the parasternal view, and in all patients in at least one of the two views. The images' quality was maximal (i.e., score = 4) in at least one of the two windows in 19 patients (79%). Atrial fibrillation arrhythmia was the only clinical characteristics associated with a poor score outcome in both imaging windows (apical p = 0.022, parasternal p = 0.014).ConclusionsThese results provide the proof-of-concept for the feasibility of an automatic ultrasonographic image acquisition system associated with an AI algorithm for real-time monitoring of cardiac motion in patients with a history of VA.
Developing Small-Molecule Inhibitors of Protein-Protein Interactions Involved in Viral Entry as Potential Antivirals for COVID-19
Authors: Buchwald Peter 
Published: April 2022

Blocking protein-protein interactions (PPIs) involved in the initiation of the cell attachment and entry of viruses is an important antiviral mechanism of action including for neutralizing antibodies. Doing it with small-molecule inhibitors (SMIs) is challenging, as it is for all other PPIs, and might require the exploration of chemical space beyond that of typical drug-like structures. However, it could lead to new antiviral agents suitable for oral administration and acting on alternative targets, considerations that are essential for the development of widely acceptable and broad-spectrum preventive or curative therapeutics. Fostemsavir, an antiretroviral that acts via blocking of the gp120–CD4 PPI, supports the feasibility of the concept. Here, a brief review of relevant drug design considerations is presented together with a summary of the progress made toward the identification of SMIs targeting the PPI between the SARS-CoV-2 spike protein and ACE2 that initiates the viral attachment and cellular entry of this coronavirus causing the COVID-19 pandemic. SMIs identified in various screening assays that were also confirmed to have antiviral activity in a live virus or pseudovirus assay with an IC50 &lt; 30 µM so far include several organic dyes (methylene blue, Evans blue, Congo red, direct violet 1), verteporfin, DRI-C23041, and cannabigerolic and cannabidiolic acids. While specificity and activity profiles still need improvement, results so far already provide proof-of-principle evidence for the feasibility of SMIs targeting the SARS-CoV-2-S–hACE2 PPI. Methylene blue, which is approved for clinical use, is orally bioactive, and could act by multiple mechanisms of action, might have potential for repurposing for COVID-19 prevention and treatment.
Integrated Analysis of Angiogenesis Related lncRNA-miRNA-mRNA in Patients With Coronary Chronic Total Occlusion Disease
Authors: Gao Wei , Zhang Jianhui , Wu Runda , Yuan Jie , Ge Junbo 
Published: April 2022

Background: Coronary chronic total occlusion (CTO) disease is common and its specific characteristic is collateral formation. The Integrated analysis of angiogenesis related lncRNA-miRNA-mRNA network remains unclear and might provide target for future studies.Methods: A total of five coronary artery disease (control group) and five CTO (CTO group) patients were selected for deep RNA and miRNA sequencing. The expression profiles of lncRNAs, mRNAs circRNA and miRNAs were obtained. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were then performed. The expression of a 14q32 miRNA gene cluster, including miRNA-494, miRNA-495 and miRNA-329, were selected to be determined in another larger patient cohort. Analysis of the lncRNA-miRNA495-mRNA network was constructed to find potential targets for future studies.Results: A total of 871 lncRNAs, 1,080 mRNAs, 138 circRNAs and 56 miRNAs were determined as differentially expressed (DE) in CTO patients compared with control patients. GO and KEGG analyses revealed that the top terms included MAPK signaling pathway, HIF-1 signaling pathway, EGFR tyrosine kinase inhibitor resistance, embryonic organ development, wound healing, MAPK signaling pathway and JAK-STAT signaling pathway, which are related to angiogenesis. The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients. Then we divided the CTO patients into two groups according to CC grade (poor CC group, CC = 0 or one; good CC group, CC = 2). MiRNA-494, miRNA-495 and miRNA-329 were found to be down-regulated in good CC group compared with poor CC group. Analysis of the lncRNA-miRNA495-mRNA network showed 3 DE lncRNA sponges (NONHSAG008675, NONHSAG020957 and NONHSAG010989), 4 DE lncRNA targets (NONHSAT079547.2, NONHSAT081776.2, NONHSAT148555.1 and NONHSAT150928.1) and 2 DE mRNA targets (RAD54L2 and ZC3H4) of miRNA495.Conclusion: This study revealed that the lncRNA-miRNA-mRNA network might play a critical role in angiogenesis in CTO patients.