bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Wait? Neuroscience Is for Everyone!
Authors: Myslinski Norbert 
Published: June 2022

AbstractNeuroscience is not just for neuroscientists. It is for everyone, but it is absent from our high schools. High schools have a huge investment in STEM but do not include neuroscience, although neuroscience is more interesting and relevant to a person’s daily life than most other sciences. However, neuroscience opportunities are increasing for teenagers outside the standard curriculum.
Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction
Authors: Sun Ling , Zhu Wenwu , Ji Yuan , Zou Ailin , Mao Lipeng , Chi Boyu , Jiang Jianguang , Zhou Xuejun , Wang Qingjie , Zhang Fengxiang 
Published: June 2022

Objective
Post-treatment contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes in patients with acute myocardial infarction (AMI). A lower free triiodothyronine (FT3) level predicts a poor prognosis of AMI patients. This study evaluated the effect of plasma FT3 level in predicting CI-AKI and short-term survival among AMI patients.

Methods
Coronary arteriography or percutaneous coronary intervention was performed in patients with AMI. A 1:3 propensity score (PS) was used to match patients in the CI-AKI group and the non-CI-AKI group.

Results
Of 1480 patients enrolled in the study, 224 (15.1%) patients developed CI-AKI. The FT3 level was lower in CI-AKI patients than in non-CI-AKI patients (3.72 ± 0.88 pmol/L vs 4.01 ± 0.80 pmol/L, P < 0.001). Compared with those at the lowest quartile of FT3, the patients at quartiles 2–4 had a higher risk of CI-AKI respectively (P for trend = 0.005). The risk of CI-AKI increased by 17.7% as FT3 level decreased by one unit after PS-matching analysis (odds ratio: 0.823; 95% CI: 0.685–0.988, P = 0.036). After a median of 31 days of follow-up (interquartile range: 30–35 days), 78 patients died, including 72 cardiogenic deaths and 6 non-cardiogenic deaths, with more deaths in the CI-AKI group than in the non-CI-AKI group (53 vs 25, P < 0.001). Kaplan–Meier survival analysis showed that patients at a lower FT3 quartile achieved a worse survival before and after matching.

Conclusion
Lower FT3 may increase the risk of CI-AKI and 1-month mortality in AMI patients.
Risk of cardiovascular events associated with pathophysiological phenotypes of type 2 diabetes
Authors: Stidsen Jacob Volmer , Christensen Diana Hedevang , Henriksen Jan Erik , Højlund Kurt , Olsen Michael Hecht , Thomsen Reimar Wernick , Christensen Lotte Brix , Nielsen Jens Steen , Olesen Thomas Bastholm , Beck-Nielsen Henning 
Published: June 2022

Abstract

Objective
Hyperglycaemia in type 2 diabetes is caused by varying degrees of two defects: low insulin sensitivity and beta-cell dysfunction. We assessed if subgrouping of patients into three pathophysiological phenotypes according to these defects could identify individuals with high or low risk of future cardiovascular events.

Design
This is a prospective cohort study.

Methods
We assessed estimates of insulin sensitivity and beta-cell function from the homeostasis model assessment-2 in 4209 individuals with recently diagnosed type 2 diabetes enrolled from general practitioners and outpatient clinics in Denmark. Individuals were followed for a composite cardiovascular endpoint (either atherosclerotic outcomes (myocardial infarction, unstable angina pectoris, stroke, coronary or peripheral revascularization), heart failure, or cardiovascular death) and all-cause mortality.

Results
Totally 417 individuals with the insulinopenic phenotype (high insulin sensitivity and low beta-cell function) had substantially lower risk of cardiovascular events (5-year cumulative incidence: 4.6% vs 10.1%; age-/sex-adjusted hazard ratio (aHR): 0.49; 95% CI: 0.30–0.82) compared with 2685 individuals with the classical phenotype (low insulin sensitivity and low beta-cell function), driven by atherosclerotic events. Conversely, 1107 individuals with the hyperinsulinaemic phenotype (low insulin sensitivity and high beta-cell function) had more cardiovascular events (5-year cumulative incidence: 12.6%; aHR: 1.33; 95% CI: 1.05–1.69), primarily driven by increased heart failure and cardiovascular death and increased all-cause mortality.

Conclusions
Simple phenotyping based on insulin sensitivity and beta-cell function predicts distinct future risks of cardiovascular events and death in patients with type 2 diabetes. These results suggest that precision medicine according to underlying type 2 pathophysiology potentially can reduce diabetes complications.
The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice
Authors: Yin Huan , Suye Suye , Zhou Zhixian , Cai Haiyi , Fu Chun 
Published: June 2022

In brief
Fanconi anemia results in subfertility and primary ovarian deficiency in females. This study reveals that disrupted meiosis in oocytes is one of the mechanisms involved.

Abstract
Fance is an important factor participating in the repair of DNA interstrand cross-links and its defect causes severe follicle depletion in female mice. To explore the underlying mechanisms, we investigated the effects of Fance on ovarian development in embryonic and newborn mice. We found that the number of oocytes was significantly decreased in Fance−/− mice as early as 13.5 days post coitum (dpc). The continuous decrease of oocytes in Fance−/− mice compared with the Fance+/+ mice led to the primordial follicles being almost exhausted at 2 days postpartum (dpp). The mitotic–meiotic transition occurred normally, but the meiotic progression was arrested in pachytene in Fance−/− oocytes. We detected the expressions of RAD51 (homologous recombination repair factor), 53BP1 (non-homologous end-joining repair factor), and γH2AX by immunostaining analysis and chromosome spreads. The expressions of 53BP1 were increased and RAD51 decreased significantly in Fance−/− oocytes compared with Fance+/+ oocytes. Also, the meiotic crossover indicated by MLH1 foci was significantly increased in Fance−/− oocytes. Oocyte proliferation and apoptosis were comparable between Fance−/− and Fance+/+ mice (P > 0.05). The aberrant high expression at 17.5 dpc and low expressions at 1 and 2 dpp indicated that the expression pattern of pluripotent marker OCT4 (POU5F1) was disordered in Fance−/− oocytes. These findings elucidate that Fance mutation leads to a progressive reduction of oocytes and disrupts the progression of meiotic prophase I but not the initiation. And, our study reveals that the potential mechanisms involve DNA damage repair, meiotic crossover, and pluripotency of oocytes.
Functional and Semantic Extension of the Sentence of the Modern Ukrainian Literary Language
Authors: Vorobets Oleksii 
Published: June 2022

The latest linguistic research has witnessed a strengthening of the analytical consideration of syntactic semantics, the introduction of functional-semantic approach to determining the specifics of the sentence, its nucleus and potentially nucleus components in the inter-categorical section. It is obvious that the analysis of the sentence semantic organization takes into consideration the functions of individual syntaxemes, their system relations network, as well as syntactic properties of grammatical classes of words. At the same time, there arises a problem of complex analysis and interpretation of the mechanisms of semantics and functioning of a syntactic organization in general, as well as each of its units in particular. Typology of the syntactic system of the Ukrainian language, introduction of changes into the "from semantics to function", "from function to semantics", "complex, semantic and functional potential" ideas, all these contribute to the study of syntactic constructions on both the superficial and deep meaning levels. It is noteworthy that linguistic semantics relies on the idea of ​​"non-alternative picture of the world" that is a generalized picture of a one-dimensional type, which excludes the option of complementary and mutually contradictory procedures in its interpretation.
Singling out of the extenders in the syntactic plane is connected to the extending way of thinking of the individual, which provides a defining conceptual background of scientific developments, acting as a tool for understanding reality in general and the extending basis of sentence construction in particular. It is the extended view of the surrounding reality allows interpreting the branched system of semantic components and meanings in various structural syntactic units.
Given that the sentence, its structure, responsible for the unity of both the superficial and deep meaning, is the sphere of functioning of syntactically tuned elements, and, therefore, a multifaceted unit allowing interaction of formal, semantic and syntactic features of sentence entities, it is the multifaceted nature of a sentence that provides the context for extenders study.
Functional-semantic extension of the sentence consists of a four-component hierarchy of extender models: elementary extender; extender complex; extender system; mega- extender, and that indicates the semantic potential of the studied syntactic units both from the standpoint of potentially main / main predication, and in terms of functioning in a framework of simple and complex sentences. The study of the problem is complemented by transformational intentions of the extending components, and it allows reaching to the deep meaning of the sentence through functional-semantic features.
Ethnopolitical Processes in the Hutsul and Boykos Regions in the 1920s (On the Documents of Local Authorities of Stanislaviv Voivodeship)
Authors: Zhernokleiev Oleh 
Published: June 2022

The events of recent years have shown the need for regional studies. The problems of regionalism have a deep historical retrospective. The Second Polish Republic attempted to change the map of regionalism, in particular in the Ukrainian Carpathians, inhibited by the Ukrainian ethnographic groups of Hutsuls, Boykos, Lemkos. This attempt was unsuccessful and the local population didn’t support it. How did the regional Polish government see these processes? Despite the significant amount of work on the given subject, the period of the 1920s is not sufficiently researched. This article focuses on the political sources of identification, namely the activities of parties and public organizations in the Hutsul and Boykiv regions of 1924–1929 within the Stanisłav Voivodeship, it studies them through the perception of local Polish authorities. The unpublished documents of the State Archives of the Ivano-Frankivsk region make up the source base of the study. The analysed documents prove that the Ukrainian national identity of the Galician Hutsuls and Boykos in the 1920s was real and functional. It was the active position of political parties as well as cultural-educational, cooperative and other organizations, the position with a distinct Ukrainian ethno-national character that played an important role in its "formation" and manifestation. The most popular parties were the Ukrainian National Democratic Union and the Ukrainian Socialist Radical Party, both of them clearly stated their disagreement concerning the issue of the Ukrainian lands being a part of Poland and they strived for an independent Ukraine. Pro-Polish parties were far from very popular. Compared to Hutsulshchyna, Galician Boykivshchyna was characterized by an obviously higher degree of ethnical politicization. The ethno-political processes of the 1920s in the Hutsul and Boykiv regions resulted in the establishment of the Ukrainian national self-consciousness. In practice, on the local level even Polish officials did not question the national roots of Hutsuls and Boykos and them being Ukrainian; this fact only adds to the artificial character of the following Polish policy of local "regionalisms" of the 1930s. In general, the imaginary picture of the ethnical-political process in the region, provided by the local authority documents, was objective. The question whether it influenced the political decision-making process is open and still to be studied.
University: Steps of Growth
Authors: Tsependa Ihor 
Published: June 2022

The origins of Vasyl Stefanyk Precarpathian National University trace back to the Pedagogical Institute established in 1941 in Stanislav, which was the regional centre at that time. During the eighty years of its existence, the educational institution developed gradually: first it functioned as the Pedagogical Institute and its long-term existence was marked by numerous significant events, then it became a classical university, and, finally, it received the title and status of a national university. In recent years, the university has undergone radical changes in all areas of its life and work. There has come to the forefront the need of focusing on the experience of European universities while preserving national and state positions. Cooperation with leading European universities has made it possible to provide students with an opportunity to obtain a diploma not only from Vasyl Stefanyk Precarpathian National University, but also from one of the Polish ones. On the part of the staff the ongoing process of supporting the Ukrainian language as the state language goes hand in hand with general and persistent efforts teachers and students to master the English language.
There have taken place significant changes in the organization of the educational process, introduction of new curricula, as well as modern teaching methods. Information technologies and the Internet have become an integral part of the educational process, while a powerful information center has been established to provide technical support for the training session organization and the online access to scientific sources. New ways of teaching presupposes the activation of the factor of students’ individual work, which accounts for independent acquisition of a significant part of the necessary information. The scientific library now has better possibilities to make scientific and educational literature essential for the training of highly qualified specialists available through the university website.
The scientific activity of teachers has risen to a new level; new scientific centers have been created, new laboratories have been equipped; there is an ongoing international project aimed at restoration of the observatory on Mount Pip Ivan in the Carpathians. There has been a significant rise in scientific output measured by the Scopus scientific metric base; in recent years the number of doctors of science has increased by a third, and new promising scientific schools have been opened. Several multivolume fundamental scientific works have seen the world. Student self-government has also intensified, cultural life is booming, there are significant achievements in sports. In the future, the university seeks to enter the top 100 best universities in the world.
Feasibility Testing of Tubes@HOME: A Mobile Application to Support Family-Delivered Enteral Care
Authors: Werner Nicole E. , Fleischman Alyssa , Warner Gemma , Barton Hanna J. , Kelly Michelle M. , Ehlenbach Mary L. , Wagner Teresa , Finesilver Sara , Katz Barbara J. , Howell Kristina D. , Nacht Carrie L. , Scheer Nora , Coller Ryan J. 
Published: June 2022

BACKGROUND
Assistance from medical devices is common for children with medical complexity (CMC) but introduces caregiving challenges. We tested the feasibility of “Tubes@HOME,” a mobile application supporting CMC family-delivered care using enteral care as a model.

METHODS
Caregivers of CMC with enteral tubes participated in a 30-day feasibility study of Tubes@HOME November 2020 through January 2021. Tubes@HOME was available on mobile devices and designed to support collaborative care and tracking over time. Key features include child profile, caregiving network management, care routines, feedback loop, and action plans. Care routines delineated nutrition, medication, and procedural tasks needed for the child: frequencies, completions, and reminders. Metadata summarized feature use among users. Feasibility was evaluated with postuse questionnaires and interviews. Measures of Tubes@HOME’s usability and usefulness included the NASA Task Load Index (TLX), System Usability Scale (SUS), and Acceptability and Use of Technology Questionnaire (AUTQ).

RESULTS
Among n = 30 children, there were 30 primary (eg, parent) and n = 22 nonprimary caregivers using Tubes@HOME. Children had a median (IQR) 10 (5.5–13) care routines created. For care routines created, 93% were marked complete at least once during the study period, with participants engaging with routines throughout study weeks 2 to 4. Results (mean [SD]) indicated low mental workload (TLX) 30.9 (12.2), good usability (SUS) 75.4 (14.7), and above-average usefulness (AUTQ) 4.0 (0.7) associated with Tubes@HOME, respectively. Interviews contextualized usefulness and suggested improvements.

CONCLUSIONS
Longitudinal use of Tubes@HOME among caregiving networks appeared feasible. Efficacy testing is needed, and outcomes could include reliability of care delivered in home and community.
Stability of Balance Performance From Childhood to Midlife
Authors: Blodgett Joanna M. , Cooper Rachel , Pinto Pereira Snehal M. , Hamer Mark 
Published: June 2022

BACKGROUND
Balance ability underlies most physical movement across life, with particular importance for older adults. No study has investigated if balance ability is established in childhood nor if associations are independent of adult factors. We investigated associations between balance performance in early (age 10) and midlife (age 46), and whether associations were independent of contributors to adult balance.

METHODS
Up to 6024 individuals from the 1970 British Cohort Study were included. At age 10, static (1-legged stand) and dynamic (backward toe-to-heel walk) balance were categorized as poor, medium, or high. Eyes open and closed 1-legged balance performance (max: 30 seconds) was assessed at age 46 with 5 categories.

RESULTS
Poor static balance at age 10 was strongly associated with worse balance ability at age 46. Relative to the highest balance group at age 46 (ie, eyes open and closed for 30 seconds), those with poor static balance had a 7.07 (4.92–10.16) greater risk of being in the poorest balance group (ie, eyes open &lt;15 seconds). Associations were robust to adjustment for childhood illness, cognition, and socioeconomic position and adult measures of height, BMI, education, exercise, word recall, and grip strength (adjusted relative risk: 5.04 [95% confidence interval: 3.46–7.37]). Associations between dynamic balance at age 10 and balance at age 46 were weaker (adjusted relative risk) of the poorest balance group: 1.84 [1.30–2.62]).

CONCLUSIONS
Early childhood may represent an important period for maturation of postural strategies involved in balance, indicating the potential for early intervention and policy changes alongside existing interventions that currently target older adults.
A comprehensive investigation into the production of gamma-aminobutyric acid by Limosilactobacillus fermentum NG16, a tuna gut isolate
Authors: Thuy D.T.B. , An N.T. , Jayasena V. , Vandamme P. 
Published: June 2022

Abstract
Gamma-aminobutyric acid (GABA), a four-carbon non-protein amino acid, is widely known to have multiple physiological functions. The present study aimed to investigate the cultivation parameters for GABA production by a lactic acid bacteria (LAB) strain isolated from a tuna gut sample. Among 60 tuna gut LAB, only 7 Limosilactobacillus fermentum isolates, i.e. NG01, NG12, NG13, NG14, NG16, NG23, and NG27, were capable of GABA fermentation, with NG16 being the most potent GABA producer. The GABA production by isolate NG16 was therefore thoroughly characterised. The optimal batch culture conditions for GABA production were an initial cell density of 5×106 CFU mL−1, a monosodium glutamate concentration of 2%, an initial pH of 7, a fermentation temperature of 35 °C, and an incubation time of 96 h. Under this cultivation conditions, NG16 produced a maximum GABA yield of 25.52 ± 0.41 mM.
Effects of multimodal training program on muscle deoxygenation in women with breast cancer: A randomized controlled trial
Authors: Hiraoui Mouadh , Gmada Nabil , Al-Hadabi Badria , Mezlini Amel , Al Busafi Majid , Doutrellot Pierre Louis , Bouhlel Ezdine , Ahmaidi Said 
Published: June 2022

Abstract

Purpose
Chemotherapy and/or radiation are the most often delivered treatments to cancer patients. Usually during the adjuvant treatment, patients complain about fatigue. In addition, physical exercise during adjuvant treatment of cancer seems to have beneficial effects. The aim of this investigation was to assess the effects of multimodal aerobic and strength exercises programs on muscle deoxygenation of patients with breast cancer undergoing adjuvant chemotherapy treatment.

Methods
Thirty-two women with breast cancer (20 patients as the training group and 12 patients as the control group) undergoing adjuvant chemotherapy participated in the study. The training group took part in 6 weeks of supervised intermittent aerobic cycling, home-based walking, isometric and electrical muscle stimulation (EMS) exercise training programs. The Outcome measures were muscle deoxygenation (ΔHHb), Maximal Voluntary isometric Contraction (MViC) and Endurance Time (ET) before and after the training period.

Results
Compared to the control group, a significant increase in ΔHHb (P < 0.01) accompanied with an increase in ET (P < 0.01) and MViC (P < 0.01) of the quadriceps was obtained in the training group. However, no significant differences of MViC, ET and ΔHHb were observed in the control group.

Conclusion
Multimodal aerobic and strength exercise programs enhance muscle oxygen utilization, which may partly explain the improvement in muscular strength and endurance, and the reduction of muscle fatigue in patients with breast cancer during an adjuvant chemotherapy period.
Laterally Varying Crustal and Quaternary Fault-Zone Structures in the Seoul Metropolitan Area, South Korea, from a Joint Inversion Analysis Based on Dense Seismic Arrays
Authors: Lee Jeongin , Hong Tae-Kyung , Park Seongjun , Lee Junhyung , Chung Dongchan , Kim Byeongwoo 
Published: June 2022

ABSTRACTThe crustal structure and Quaternary fault zone in the Seoul metropolitan area are investigated using a joint inversion that combines the receiver functions with surface wave dispersion based on seismic data from densely deployed seismic arrays. The uncertainty in inverted models is examined through a set of synthetic experiments. Synthetic tests and comparisons with other methods verify the observed crustal features. The Moho depths range between 28.7 and 32.8 km with relatively shallow depths in the central Seoul metropolitan area. The VP/VS ratio varies between 1.67 and 1.85. A Conrad discontinuity with a weak velocity increase is present at a depth of ∼20 km. Low-velocity anomalies appear at depths of ∼3 km and 6–11 km along the Chugaryeong fault zone and fault junction area. Apparent shear wave velocity contrasts appear across the fault zone where earthquakes are clustered. A high-velocity block in the western Seoul metropolitan area lies along the fault zone that runs across western Seoul. The shear wave velocity models and seismicity suggest that the fault zone may extend to a depth of 11 km at least.