bluuebunny/crossref_metadata_2025_split huggingface dataset:
Admission D-dimer to Lymphocyte counts ratio as a novel biomarker for predicting the in-hospital mortality in patients with acute aortic dissection
Authors: xu yansong , liang silei , liang zheng , luo yihuan 
Published: March 2022

Abstract
Background Inflammatory factor is a well-established indictor for vascular disease but D-dimer to Lymphocyte count ratio (DLR) is not measured in routine clinical care. Screening of DLR in individuals may identify individuals at in-hopital mortality of acute aortic dissection(AD).Methods A retrospective analysis of clinical data from 2013 to 2020 was conducted to identify which factors were related to in-hospital mortality risk. Baseline clinical features, cardiovascular risk factors, and laboratory parameters were obtained from the hospital database. The end point was in-hospital mortality. Forward conditional logistic regression was performed to identify independent risk factors for in-hospital death. Cut-off value of DLR should be ideally calculated by Receiver operating characteristic (ROC) analysis. Results The in-hospital mortality rate was 15% (48 of 320 patients). Patients with in-hospital mortality had higher admission mean DLR level than the alive group (1740 vs. 1010, P < .05). The cutoff point of DLR was 907. The in-hospital mortality rate in high level DLR group was significantly higher than that in low level DLR group (P < .05). Univariate analysis showed that 8 of 38 factors were associated with in-hospital mortality (P<.05), including admission WBC, Neutrophil, lymphocyte, neutrophil/lymphocyte（NLR）, Prothrombin time（PT）, Heart rate(HR), D - dimer, DLR. In multivariate analysis, DLR (odds ratio [OR] 2.127, 95% CI 1.034-4.373, P=0.040), HR (odds ratio [OR] 1.016, 95% CI 1.002-1.030, P=0.029) and PT (odds ratio [OR] 1.231, 95% CI 1.018-1.189, P=0.032) were determined as independent predictors of in-hospital mortality (P < .05). Conclusions: Serum DLR level on admission is an independent predictor of in-hospital mortality in patients with acute AD.
Psychometric properties of the German Version of the Psychological Consequences of Screening Questionnaire (PCQ)
Authors: Fichtner Urs A. , Maun Andy , Farin-Glattacker Erik 
Published: March 2022

Abstract
Background:This study aimed to translate the negative and positive items of the Psychological Consequences Questionnaire (PCQ) into German, to adapt this version to the context of screening for cirrhosis and fibrosis of the liver, and to test its psychometric properties. Methods:The three subscales (physical, emotional, and social) were translated into German using a forward-backward translation method. Furthermore, we adapted the wording to the context of liver diseases. We tested the acceptability, distribution properties, internal consistency, scale structure, and the convergent validity using an analysis sample of 443 patients who were screened for cirrhosis or fibrosis of the liver. Results:We found low non-response and non-unique answer rates on the PCQ items in general. However, positive items had higher non-response rates. All items showed strong floor effects. Cronbach’s alpha was high for both the negative (α=0.95) and the positive PCQ scale (α=0.90), as well as for the total PCQ scale (α=0.90). Confirmatory factor analysis could reproduce the three dimensions that the PCQ intends to measure. However, it suggests not summing up a total PCQ score and instead treat the subscales separately. Convergent validity with the short form of the Spielberger State-Trait Anxiety Inventory (STAI-Y-6) was acceptable. Conclusions: Overall, our study results report a successful adaptation of the German PCQ with good performance in terms of acceptability, internal consistency, scale structure, and convergent validity. Floor-effects limit the content validity of the PCQ, which needs to be addressed in future research. However, the German version of the PCQ is a useful measurement for both negative and positive screening consequences, even in a non-cancer setting.
The Effect Of Educational Support Intervention For Infant Care On The Growth Rates Of Infants, Breastfeeding Self-Efficacy And Quality Of Life Of Their Mothers And Sharing The Experiences Of Peer Groups: Study Protocol
Authors: Okhovat Forogh , Okhovat Shirin , Karimiankakolaki Zohreh , Yoshani Nooshin 
Published: March 2022

Abstract
Background: Mother's knowledge of how to deal properly with the infant's problems and provide the necessary care can increase the mother's confidence in providing care for her infant and eliminate misconceptions in primiparous mothers. The present study was conducted to the effect of educational support intervention for infant care on the growth rates of infants, breastfeeding self-efficacy and quality of life of their mothers and sharing the experiences of peer groups.Methods: This quasi-experimental study is an educational support intervention protocol for infant care which will be conducted in two phases. The educational support program will be designed in the first phase. The program includes educational sessions on breastfeeding, growth and development of infants and care for children under two years of age in a virtual group where a physician, a nurse, a midwife and a healthcare provider are also present. Using the opinions of the experts, the peer group will discuss various points and the research team will finalize the program based on priorities. The second phase of the educational intervention will be conducted experimentally as a pretest-posttest design for the intervention and control groups.Discussion: The present study provides useful data about the effect of educational support intervention for infant care and the sharing peer group experiences on infants' growth rates, breastfeeding self-efficacy, and quality of life of their mothers. the current educational package not only combines virtual education and peer experiences in strengthening the education of mothers, but also it can improve mothers' physical and mental health and reduce medical costs by using telephone follow-up in supporting the mothers of infants.Trial registration: Registration of this randomized control trial has been completed with the Iranian Registry of Clinical Trials, IRCT20210913052457N1, registered 9/10/2021, https://www.irct.ir/trial/59093
Establishment and spread of the invasive ladybird Harmonia axyridis (Coleoptera: Coccinellidae) in Greece: based on contributions from citizen scientists
Authors: Angelidou Ioanna , Demetriou Jakovos , Christou Maria , Koutsoukos Evangelos , Kazilas Christos , Georgiades Pantelis , Kalaentzis Konstantinos , Kontodimas Dimitris , Groom Quentin , Roy Helen E , Martinou Angeliki F 
Published: March 2022

Abstract
Harmonia axyridis (Pallas, 1773), also known as the harlequin ladybird, is an invasive alien species intentionally introduced to many countries as a biological control agent of agricultural pests. In Greece, H. axyridis was first introduced as a biological control agent in 1994, with releases taking place between 1994 and 2000. For many years there was no evidence to indicate that H. axyridis had established self-sustaining populations. Following introduction to Greece in 2008, a recording scheme was launched but unfortunately failed to yield results and was discontinued meanwhile several online platforms have become available. Our study examines records from iΝaturalist and other databases, such as Alientoma and social media demonstrating that H. axyridis has been established in Greece since 2010. The distribution, phenology and presence of H. axyridis in different habitat types and protected areas are investigated, using both citizen science data and literature records. H. axyridis is present in 13 administrative districts of Greece, most of them in considerable distance from the initial release sites, and mainly inhabits urban and agricultural habitats as well as 17 NATURA 2000 sites. The adverse socioeconomic and environmental impacts of H. axyridis are briefly discussed alongside suggestions for action. Based on our findings, we propose the establishment of a national monitoring scheme for H. axyridis and native ladybirds, encouraging public participation in recording ladybird observations that will provide information on the distribution, spread and impact of this invasive alien species.
Therapeutic Plasma Exchange: Impact on Survival in Patients With Covid-19
Authors: Fonseca-González Gandhi , Alamilla-Sánchez Mario , García-Macas Vanessa , Herrera-Acevedo José , Villalobos-Brito Mauricio , Tapia-Rangel Edgar , Maldonado-Tapia Diana , López-Mendoza Mónica , Cano-Cervantes José Horacio , Orozco-Vázquez Julita , Timarán-Montenegro David , Cortés-Martínez Silvia , Escarela-Serrano Maricela , Muñoz-López Sandra , Montiel-López Luis , Mondragón-Terán Paul , Suárez-Cuenca Juan Antonio 
Published: March 2022

Abstract
BACKGROUND. Five percent of cases of COVID-19 will develop acute respiratory distress syndrome and cytokine storm syndrome, which are leading causes of death in patients with SARS-CoV-2 infection. Plasma exchange therapy (PLEX) effectively removes pro-inflammatory factors, modulating and restoring innate and adaptive immune responses. This clinical trial aimed to evaluate the impact of PLEX on the survival of patients with severe SARS-CoV-2 and the effect on the cytokine release syndrome. METHODS. Hospitalized patients diagnosed with SARS-CoV-2 infection and cytokine storm syndrome were selected to receive 2 sessions of PLEX or standard therapy. Primary outcome was all-cause 60-days mortality; secondary outcome was requirement of mechanical ventilation, SOFA, NEWs-2 scores modification, reduction of pro-inflammatory biomarkers and hospitalization time. RESULTS. Twenty patients received PLEX were compared against 40 patients receiving standard therapy. PLEX reduced 60-days mortality (50% vs 20%; OR 0.25, 95%CI 0.071 - 0.880; p = 0.029), and this effect was independent from demographic variables and drug therapies used. PLEX significantly decreased SOFA, NEWs-2, pro-inflammatory mediators and increased lymphocyte count, accompanied with a trend to reduce affected lung volume, without effect on SatO2/FiO2 indicator or mechanical ventilation requirement.CONCLUSIONS. PLEX therapy provided significant benefits of pro-inflammatory clearance and reduction of 60-days mortality in selected patients with COVID-19, without significant adverse events.
HCA587/MAGE-C2 protein formulated with CFA and CpG elicits potent immune responses and antitumor effects in mice
Authors: Jiao Wei , Chen Huiyuan , Zhang Lijie , Yang Weiming , Yin Yanhui , Chen Juanjuan 
Published: March 2022

Abstract
Background
HCA587/MAGE-C2 is a cancer-testis (CT) antigen, which is expressed in immunoprivileged germ-line regions and many kinds of tumor tissues. In the present study, we developed a novel recombinant HCA587 protein vaccine with Freund’s adjuvants and CpG as adjuvant. The objective is to survey its ability inducing antigen specific immune response and antitumor activity in mice model.
Methods
The levels of cellular and humoral immune responses induced by different regimens were compared by IFN-γ ELISpot and Ab ELISA, as well as by intracellular cytokine staining (ICS) analysis in different vaccination strategies. The tumor volume was measured and the survival curve was evaluated by log-rank test.
Results
After the comparison of different strategies, HCA587 protein with CFA and 50µg CpG elicited strongest specific IFN-γ-secreting splenocytes and anti-HCA587 antibody. And this vaccine combination induced highest IFN-γ+CD4+ T cells by ICS analysis. When the B16-HCA587 tumor-bearing mice were inoculated with the HCA587 protein vaccine combined with CFA and CpG, the tumor growth was retarded significantly with no change of survival time.
Conclusion
Our data indicates that HCA587 protein formulated with CFA and 50µg CpG elicits potent cellular and humoral immune responses and partial antitumor effect in mice model. This provides new experimental data for the preclinical research of HCA587 protein vaccine.
The Relationship Between Surgical Loupes Usage, Workplace Ergonomics, and Musculoskeletal Disorders Among Saudi Ophthalmologists
Authors: AlOqab Aysha , AlTurkistany Walaa , Ali Hala M Nassim 
Published: March 2022

Abstract
Objective: Evaluate the knowledge, attitudes, and practices of surgical loupes among ophthalmologists and determine the relationship between this tool and musculoskeletal disorders. Methods: An anonymous, internet-based survey via Google forms was distributed among ophthalmologists (trainees and consultants) working in Saudi Arabia between December 2020 and January 2021. Results: 93 surveys were completed, and 82% reported pain with operating during the past 12 months. Neck pain was reported in 87%, shoulder pain 81%, and lower back pain 73%. 68% chose to rest without seeking professional care. 47% of participants exercise regularly. 69% attributed the pain to “bending or twisting your neck.” 55% of surgeons owned loupes, only a third used loupes regularly. 40% indicated limited field of vision as the main limitation. Chi-Squared analysis showed that musculoskeletal (MSK) pain is a risk among all ophthalmic surgeons. It was more prevalent among surgeons with longer experience. Higher rates of pain noted with increased surgical volume and prolonged operating time. Additionally, more frequent loupe use was associated with an increased prevalence of pain. None were found to be statistically significant. Finally, the activity level was significantly associated with a lower prevalence of pain (P = 0.028). Conclusion: We established that the majority of participants experienced occupational MSK pain. Most participants owned loupes. Only a third used loupes regularly. This is most likely due to prolonged operating time, static positioning, and neck flexion, producing the “head forward” posture. Young ophthalmologists should be encouraged to apply ergonomic principles to safeguard against future MSK injuries.
Is selective hip dislocation screening at the age of 4 months sufficient?
Authors: Matsubayashi Shohei , Matsuzaki Hiroki , Tsujimoto Ritsu , Osaki Makoto 
Published: March 2022

Abstract
Background This study aimed to investigate whether performing selective hip dislocation screening at the age of 4 months would result in refractory or overlooked cases.MethodsThe study included 526 hips of 263 infants were screened for hip dislocation at a primary health check-up, and then visited our department for secondary health check-ups for hip dislocation. Ultrasonography was performed at the initial visit and 3 months later. X-rays were performed at the age of 1 year, and the proportion of patients with an acetabular index of ≥30° were evaluated.ResultsThe mean age at the initial visit was 4.6 months. The percentage of patients diagnosed with developmental dysplasia of the hip was 4.9%. There were no refractory cases. Moreover, none of the patients with Graf classification Type I at the initial visit worsened to ≥Grade II after 3 months. The acetabular index was ≥30° in 35 of the 402 hips (8.7%) at the age of 1 year.ConclusionPerforming selective hip dislocation screening at the age of 4 months did not lead to any refractory cases or delayed diagnoses.
Improved Hole Repairing Method Based on Wavefront Method
Authors: Huang Jing , Li Weicong , Ye Mengjie 
Published: March 2022

Abstract
Due to the emergence of 3D scanning technology, in the process of acquiring spatial information of the model, incomplete data often results in the loss of model data, which leads to holes in the acquired digital model. The defective model affects the appearance of the model. What’s more, it will cause a lot of inconvenience to the subsequent researches and treatments. With regard to the problems existing in the hole repairing of 3D scanning model, a hole repairing method based on the improved wavefront method is proposed in the paper. After the initial mesh is formed by virtue of the wavefront method, the curvature can be repaired and the triangle patch can be rotated to a reasonable position. The experimental results show that the algorithm can effectively and quickly generate high-quality closed meshes in the corresponding hole types. Besides, it can accurately restore the geometric features of the hole area while retaining the original information of the model. The algorithm of the paper can be applied in the fields of reverse engineering, archaeology, digital heritage, medical visualization, 3D reconstruction, etc.
Rupturing Aromaticity by Periphery Overcrowding
Authors: Saha Promeet , Mallick Abhijit , Turley Andrew , Bismillah Aisha , Danos Andrew , Monkman Andrew , Avestro Alyssa-Jennifer , Yufit Dmitry , McGonigal Paul 
Published: March 2022

Abstract
The balance between strain relief and aromatic stabilization dictates the form and function of nonplanar π-aromatics. Overcrowded systems undergo geometric deformations, but the energetically favourable π-electron delocalization of their aromatic ring(s) is typically preserved. Here, we use peripheral overcrowding to increment the strain energy of an aromatic system beyond its aromatic stabilization energy, causing the ring system to rearrange and aromaticity to be ruptured. Firstly, increasing steric bulk around the periphery of π-extended tropylium ring systems leads them to deviate from planarity. We observe contorted conformations with end-to-end twists of up to 45.2°. Aromatic stabilization and strain energies are closely matched at this critical point. Upon further increasing the strain, the aromatic π-electron delocalization of the system is broken—the aromatic tropylium ring rearranges to a nonaromatic, bicyclic analogue, ‘Dewar tropylium’. Remarkably, by counterbalancing strain against aromatic stabilization energy, we observe that these aromatic and nonaromatic isomers can exist in equilibrium with one another. Dynamic NMR measurements reveal that the isomers interconvert rapidly. This investigation of the antagonistic relationship between aromaticity and strain provides direct experimental insights into the fundamental nature of aromaticity and demarcates the extent of steric deformation tolerated by an aromatic carbocycle.
The effects of asymmetric sitting postures on the trapezius and erector spinae during a computer mouse task in sedentary people
Authors: Shih Chih-Wen , Chiu Hsiao-Ping , Liu Chien-Hsiou 
Published: March 2022

Abstract
Background
Although a neutral sitting posture is recommended to avoid potentially musculoskeletal discomfort, many asymmetric sitting postures are still adopted during a computer mouse task in sedentary people. The computer mouse task is also an asymmetric upper extremity task. Both asymmetric sitting posture and asymmetric upper extremity task have detrimental effects for long-term sedentary people.
Objectives
To determine how personal characteristics (gender, age, BMI) influenced sedentary people, to investigate the effects of asymmetric sitting postures on muscular activity of trapezius and erector spinae, and to evaluate the differences in the right and left muscular activities during a computer mouse task in sedentary people.
Methods
A 3x3x2 (Backrest conditions x Lower extremity conditions x Right-left difference of examined muscles) repeated-measured experiment was design. The activities of four muscles (the trapezius and erector spinae on both sides) were collected by surface electromyography. Sixty sedentary people were recruited and randomly assigned sitting postures. All of them were right handed, and the right side was task side.
Results
For the personal characteristics, the female group in Gender variable and the underweight groups in BMI variable appeared lower EMG activity in trapezius. The 20–29 and forty-and-over groups in Age variable and healthy group in BMI variable appeared higher EMG activity in erector spinae. The trapezius activity was lower in the left cross-legged sitting posture than in the symmetric sitting posture. The erector spinae activity was higher in the right side than in the left side in both the left and the right cross-legged sitting postures.
Conclusion
The compensation mechanism of lower back regions was found in asymmetric sitting postures, although the muscle activity of neck/shoulders regions decreased in the non-task side cross-legged sitting postures. The present study suggests that asymmetric sitting postures are not appropriate options for sedentary people during the operation of a computer mouse.
Differential expression of Ago2-mediated microRNA signaling in adipose tissue is associated with food induced obesity
Authors: Yan Xin , Zhang Hansi , Qiao Liang , Liu Xiaoxuan , Han Xiaojing , Kang Jing , Liu Yanli , Lin Juntang 
Published: March 2022

Abstract
Adipose tissue is a major component for the regulation of energy homeostasis by storage and release of lipids. As a core element of RNA-induced silencing complex, Ago2 plays critical role in maintenance of systemic metabolic demand. Here we show that high-fat diet feeding mice exhibited an increase in body mass alongside systematic insulin resistance and altered rate of energy expenditure. Interestingly, Ago2 expression is associated with obesity and increased in adipose tissues. Moreover, increase of Ago2 inhibited the expression of AMPKα by promoting its targeting by miR-148a, the most abundant microRNA in the adipose tissues. Those results suggested that Ago2-miR-148a-AMPKα signaling pathway play an important function in the developing obesity and adiposity and will further provide basic research data for the potential clinic treatment of obesity.
Clinical and economic value of oral nutrition supplements in cancer patients: a position paper from the Survivorship Care and Nutritional Support Working Group of Alliance Against Cancer.
Authors: Caccialanza Riccardo , Laviano Alessandro , Bosetti Cristina , Nardi Mariateresa , Casalone Valentina , Titta Lucilla , Mele Roberto , De Pergola Giovanni , De Lorenzo Francesco , Pedrazzoli Paolo , Cancer Survivorship Care and Nutritional Support Working Alliance A 
Published: March 2022

Abstract
Malnutrition is a common clinical and public health problem that can frequently affect subjects in hospital and community settings. In particular, cancer-related malnutrition results from a combination of metabolic dysregulation and anorexia, caused both by the tumor itself and by its treatment. Patients with head-neck cancer, or with gastroesophageal, pancreatic, lung and colorectal cancer, are particularly at risk of developing malnutrition, with a prevalence varying between 30% and 50% since the early disease phases, according to the tumor location and anti-cancer treatment complications. Prevention and adequate management of malnutrition is now considered an essential key point of therapeutic pathways of cancer patients, with the aim to enhance their quality of life, reduce complications and improve clinical outcomes. Oral nutritional supplements (ONS) are part of the nutritional therapy and represent an effective tool to deal with cancer-related malnutrition, as supported by growing literature data. However, patients’ access to ONS - which is regulated by different national and regional policies in terms of reimbursement - is quite heterogeneous. This narrative review aims to summarize the current knowledge about the role of ONS in terms of cost-effectiveness in the management of actively treated cancer patients, following surgery and/or radiotherapy/chemotherapy treatment and to present the position on this issue of Alliance Against Cancer, the Italian National Oncology Network.