bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the efficiency of implementation of public-private partnership projects taking into account their life cycles and key stakeholders’ interests
Authors: Merzlov I. Yu. 
Published: September 2022

Objective: to develop criteria for objective and comprehensive assessment of the success of public-private partnership (PPP) projects.Methods: in the process of the research, the method of systematic literature review was used.Results: as a result of the study, it was concluded that the success of a PPP project is a relative concept and requires detailing (1) from the viewpoint of which particular stakeholder the project is evaluated and (2) relative to which stage of the project life cycle the assessment is made. This understanding allowed proposing a universal approach to assessing the success of PPP projects, based on the criteria assessment matrix developed by us, which takes into account the stages of the project life cycle and the interests of its stakeholders.Scientific novelty: the systematization of studies available in the Russian and world literature concerning the assessment of the success of both investment projects in general and PPP projects in particular allowed identifying a universal set of criteria for such an assessment. This, in turn, contributes to a more adequate and clear interpretation of the conclusions made by a wide range of authors of research in the field of PPP, who quite often refer to “successful” PPP projects, without giving their own understanding of the criteria for determining success.Practical significance: the developed criteria matrix for assessing the success of PPP projects can become a starting point for improving methodological approaches and normative-legal documents regulating the implementation of PPP projects at the federal and regional levels. Regional and municipal executive authorities planning the implementation of new PPP projects can use the proposed matrix for assessing the success of PPP projects in their work in order, on the one hand, to increase the investment attractiveness of the projects being developed, and on the other hand, to ensure better and objective control over their further implementation.
Unmasking the Tissue-Resident Eukaryotic DNA Virome in Humans
Authors: Pyöriä Lari , Pratas Diogo , Toppinen Mari , Hedman Klaus , Sajantila Antti , Perdomo Maria F. 
Published: September 2022

Abstract
Background

Little is known on the landscape of viruses that have taken residence within our cells, nor on the interplay with the host imperative for their persistence. However, a lifetime of interactions conceivably have an imprint on our physiology and immune phenotype. Importantly, current metagenomics-insights on the healthy human virome are derived from bodily fluids, which are only a proxy of the true prevalence of human eukaryotic viruses within tissues. Most significantly, the virome’s systemic composition across the different organs of an individual has thus far remained uncharted.

Results

In this work, we revealed the genetic make-up of the eukaryotic human DNA virome in the body and showed that each organ (colon, liver, lung, heart, brain, kidney, skin, blood, hair) has unique viral compositions. By integration of quantitative (qPCR) and qualitative (hybrid-capture sequencing) analysis, we identified the DNAs of 17 viruses, primarily herpes-,
parvo-, papilloma- and anello-viruses (>80% prevalence), typically persisting in low copies (mean 540 copies/ million cells). The within-sample diversities (a-diversity) were highest in the lung, liver, colon, and kidney. We assembled in total 70 viral genomes (>90% breadth coverage), distinct in each of the individuals, and identified high sequence homology across the organs. Moreover, we detected variations in virome composition and distribution in two individuals with underlying malignant conditions.

Conclusions

Our findings reveal unprecedented prevalences of viral DNAs in human organs. We showed that bodily fluids, although accessible to sampling, fail to deliver a comprehensive view of the numerous intracellular viruses colonizing our tissues. Our data demonstrate how a multi-organ approach is essential for analyzing differing virome compositions in various disease states. This atlas provides a fundamental ground for the studies of correlates to disease, and for the interpretation of next-generation sequencing data in clinical virology. Ultimately, our findings call for investigation of the crosstalk between human DNA viruses, the host, and other microbes, as it predictably has a significant impact on our health.
Improving sexual dysfunction through guided imagery and music (GIM): A clinical trial study
Authors: Mohammadi Elahe , AbdiShahshahani Mahshid , Noroozi Mahnaz , Mohammadi Ali Zade , Beigi Marjan 
Published: September 2022

Abstract
Background
Women with perfect health are strong foundations of a healthy and prosperous family life and suppressing the natural needs of women will have adverse effects on the intimacy and vitality of family members especially in the field of sexual function. This study aimed to determine the effect of guided imagery and music (GIM) on the level of sexual function in women with sexual dysfunction.
Methods
This study was performed as a clinical trial on 72 women of reproductive age with sexual dysfunction (two 36-individual groups) referred to comprehensive health centers in Isfahan, Iran. Sampling was conducted in a convenience way and by step-by-step stages of guided imagery and music. No special intervention was performed in the control group. Data collection tools were demographic characteristics questionnaire and standard questionnaire of female sexual function index. Data analysis was performed by SPSS software using descriptive and analytical statistics with 95% confidence level.
Result
There was no statistically significant difference in sexual function and demographic characteristics before the intervention between the two groups (Pvalue > 0.05). The results demonstrated that the overall score of sexual function in the intervention subjects was better than the control group. (Pvalue < 0.05) Improvement of sexual function dimensions (desire, arousal, orgasm) were also significant in the intervention group compared to the control group (Pvalue < 0.05).
Conclusion
Guided imagery and music (GIM) can be effective in improving women sexual function. This technique is recommended for reproductive age women with sexual dysfunction or women who want to enhance sexual function.
In vitro anti-hepatocellular carcinogenesis of 1,2,3,4,6-Penta-O- galloyl-β-D-glucose
Authors: Jiang Yuhan , Bi Jing-hui , Wu Minrui , Ye Shijie , Hu Lei , Yi Yang , Wang Hongxun , Wang Li-mei 
Published: September 2022

Abstract
The main aim of this study was to explore the antitumor effects and mechanism of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose on human hepatocellular carcinoma HepG2 cells. A network pharmacology method was first used to predict the possible inhibition of hepatocellular carcinoma growth by β-PGG through the p53 signaling pathway. Next, the CCK-8 assay was performed to evaluate changes in the survival rate of human hepatocellular carcinoma HepG2 cells treated with different concentrations of the drug; flow cytometry was used to detect changes in cell cycle, apoptosis, mitochondrial membrane potential, and intracellular Ca2+ concentration; and real-time fluorescence quantification and immunoblotting were performed to evaluate changes in the expression of P53, BAX, and BCL-2. Results showed that the expression of P53 genes and proteins associated with the p53 signaling pathway was significantly increased by β-PGG treatment. It was found that β-PGG significantly inhibited survival of HepG2 cells, promoted apoptosis, decreased mitochondrial membrane potential and intracellular Ca2+ concentration, upregulated P53 gene and protein expression, increased CASP3 expression, and induced apoptosis in HepG2 cells. In conclusion, this study has shown that network pharmacology can accurately predict the target of β-PGG's anti-hepatocellular carcinoma action. Moreover, it was evident that β-PGG can induce apoptosis in HepG2 cells by activating the p53 signaling pathway to achieve its anti-hepatocellular carcinoma effect in vitro.
Factors determining assistance needs for social voluntary services among home-based elderly in Chinese urban areas: a cross-sectional study
Authors: Huang Lei , Zhang Fengjian , Zhao Huimin , Chen Yuqin , Feng Mingjiao , You Yanjie , Peng Xiao , Guan Chunyan , Liu Yilan 
Published: September 2022

Abstract
Background
With a rapidly aging population in China, it is becoming increasingly challenging to meet the growing diversified care needs of the elderly. Although social voluntary services has numerous advantages and is popular among the elderly, little information is available on the assistance requirements of the volunteer-based social service, particularly those with a medical background and influencing factors among the urban home-based elderly.
Methods
A cross-sectional study was conducted in four urban communities in Wuhan, Ezhou, Xinxiang, and Zhengzhou. Assistance needs was assessed using the 27-item Home-based Elderly Assistance Need Scale in 498 participants, aged 60 years and over. Multiple linear regression models were conducted to identify salient variables associated with assistance needs for social voluntary services.
Results
The mean score of assistance needs was 88.60 +/- 24.37. The item mean scores examining 4 dimensions, namely, health maintenance, visiting communication, social intercourse, and daily life were 3.64 +/- 1.08, 3.49 +/- 1.04, 3.33 +/- 1.08, and 2.78 +/- 1.08, respectively. The level of depression, willingness to help other elderly people, attaching importance to health preservation, willingness to seek help from others, existence of more children, and living parents were positively associated with assistance needs for social voluntary services, while social care from government departments was a negative factor. The aforementioned seven factors explained 28.4% of the total variance.
Conclusions
The urban home-based elderly population exhibited a high assistance demand for social volunteer services in China, and several complex factors were associated with an elevated assistance need. Our findings are beneficial for the extremely limited social volunteers, particularly, those with a medical background, to identify the priority of providing assistance services to the huge urban home-based elderly population, and improve service behavior.
Structural and optical properties of GaAs and InAs for doping Sb under the effect of pressure and temperature: DFT and EPM investigations
Authors: Othman Mazin SH. , Elkenany Elkenany B 
Published: September 2022

Abstract
We have developed first-principles calculations utilizing the empirical pseudopotential method (EPM) and density functional theory (DFT) to examine the basic behaviors of the GaAs and InAs semiconductor compounds for doped Sb. The electronic and optical responses of these compounds were calculated. We examined the impacts of the temperature and pressure with the energy band forbidden and parameters of optical parameters (static dielectric constant) of the considered compounds. The literature hasn't fully analyzed the electronic and optical characteristics of the compounds with doping Sb under the impact of pressure and temperature for fixed composition (x=0.5). So, we concentrated on the study of these properties.
Measuring Australia’s Health Security Preparedness: Calculation and Application of the National Health Security Preparedness Index for Australia
Authors: Do Phu Cong , Alemu Yibeltal , Reid Simon 
Published: September 2022

Abstract
Background
With on-going efforts to strengthen public health security, there is a need to identify areas for improvement. Existing tools designed to measure health security have limitations and the COVID-19 pandemic has revealed their limited predicative capabilities. The National Health Security Preparedness Index (NHSPI) developed in the United States (US) uses an expanded set of indicators beyond the health sector to quantify health security preparedness. The NHSPI has not been applied outside the US, so we aimed to calculate the NHSPI for Australia and compare it to the US to evaluate its predictive ability.
Methods
The NHSPI for Australia was calculated using the 140 indicators across 6 domains and 19 sub-domains described in the 2019 US release [1]. Data for each indicator was collected through grey literature searches for analogous Australian datasets. Sub-domain, domain, and national scores were computed using the formula described in the US methodology.
Results
The overall NHSPI score for Australia was 7.3 (99% Cl, 7.2–7.4), which is significantly higher than the score for the US during the same period 6.8 (99% Cl, 6.6–6.9). There was minimal variation between the overall scores for each Australian State and Territory, and for each of the domains.
Conclusion
The interpretation of the NHSPI should not be used as a predicator for population health outcomes. The greater NHSPI score for Australia than the US suggests greater homogeneity between likely demonstrates greater capacity to implement consistent of public health legislation and capacity. Further work to improve overall interpretability is needed and can be done so by refining the core NHSPI methodology to incorporate a global perspective to facilitate uptake in other national contexts.
Microscopic properties and neutralization mechanism of steel slag in acid mine drainage (AMD) remediation process
Authors: Yang Lei , Tang Yuegang , Cao Duanning , Yang Mingyuan , He Yuanyuan , Lu Cunfang 
Published: September 2022

Abstract
Steel slag has been proven to be an effective environment remediation media for acid neutralization, and a potential aid to mitigate acid mine drainage (AMD) in passive treatment process. But its acid neutralization capacity (ANC) is frequently inhibited by precipitate after a period of time, while the characteristic of the formation process are unclear yet. In this work, ANC of the SS sample was tested using simulated AMD (H2SO4, 0.1M) and real AMD. Steel slag and AMD has been characterized on pH, ANC, as well as Ca, Mg, Al, Mg-bearing ingredients. Microscopic properties characterization and neutralization experiment results shown that Ca-bearing constitutes leaching and sulfate formation were the two main categories reactions throughout the neutralization process. A prominent transition point of the two kind reactions was selected at 40 % of the neutralization process. Microscopic properties characterization indicated Ca3SiO5 (C3S) played a dominant role among Ca-bearing components in alkaline releasing stage for the present sample. Morphology, pore distribution, composition, surface area and other microscopic properties of the neutralized slag were significantly changed by the crystallized CaSO4 precipitates in sulfate formation stage, which hindered the alkaline releasing behaviors gradually. Neutralization experiments conducted by real AMD suggested that the steel slag ANC property was also influenced by the contained high concentration metal ion due to the precipitate reactions except for sulfate formation reactions.
Multiple types of programmed necrosis such as necroptosis, pyroptosis, oxytosis/ferroptosis, and parthanatos contribute simultaneously to retinal damage after ischemia-reperfusion
Authors: Dvoriantchikova Galina , Lypka Karin Rose , Adis Emily Victoria , Ivanov Dmitry 
Published: September 2022

Abstract
Ischemia-reperfusion (IR) injury is implicated in a large array of pathological conditions in the retina. Increasing experimental evidence suggests that programmed necrosis makes a significant contribution to inflammation and retinal damage triggered by IR. Since there are many types of programmed necrosis, it is important to identify those involved in retinal IR to determine the correct treatment. To this end, we used a mouse model of retinal IR and a variety of approaches including RNA-seq data analysis. Our RNA-seq data revealed the rapid development of ischemic pathology in the retina during the first 24 hours after reperfusion. We found that at least four types of programmed necrosis including necroptosis, pyroptosis, oxytosis/ferroptosis, and parthanatos are simultaneously involved in retinal IR. Our data suggest that the high activity of the TNF pathway at the early stage of retinal IR leads to early activation of necroptosis while significant activity of other types of programmed necrosis appears later. Our results indicate that TNF, glutamate, and ferrous iron generated by Steap3 may be key players concurrently triggering at least necroptosis, oxytosis/ferroptosis, and parthanatos in ischemic retinal ganglion cells (RGCs). Thus, multiple signaling cascades involved in programmed necrosis should be synchronously targeted for therapeutic purposes to treat retinal IR.
Study of the fatigue delamination behaviour of adhesive joints in carbon fibre reinforced epoxy composites, influence of the period of exposure to saline environment
Authors: Argüelles A. , Viña I. , Vigón P. , Lozano M. , Viña J. 
Published: September 2022

Abstract
This work analyses the fatigue delamination and fracture stress behaviour under mode I of adhesive joints made on an epoxy matrix composite material with unidirectional carbon fibre reinforcement and a commercial epoxy-based adhesive. DCB type tests (for mode I) were used with the aim to quantify the influence of the period of exposure to a degradation process in a salt spray chamber, to which the tested samples were subjected, on their fatigue behaviour. For this purpose and after a previous static characterisation of the material in which the critical values of the energy release rate for different exposure periods were determined, the levels of the energy release rate (ERR) to be applied in the fatigue tests and the exposure periods to be considered (no exposure, exposure during one week and twelve weeks) and a ratio of fatigue stress levels of R = Gmin/Gmax=0.1 were defined. From this experimental data, the G-N fatigue initiation curves and the G-da/dN growth curves were obtained. The experimental data obtained, in the fatigue initiation phase of the delamination process, have been treated by means of a probabilistic model based on a Weibull distribution, the application of models of these characteristics has allowed a better interpretation of the experimental results obtained. The most relevant result of the work is that, in general, the fatigue limits obtained for the adhesive joint, under mode I fracture, when subjected to a degradation process in a saline environment, do not translate into a relevant loss of its resistance capacity against this fatigue delamination phenomenon, in its initiation phase. On the other hand, the crack growth rates of the material subjected to different periods of exposure to a saline environment are similar and higher than those obtained for the material without exposure.
Inequality and Determinants of Female Workforce Participation in Agriculture of Uttar Pradesh, India
Authors: . Renu 
Published: September 2022

Abstract
The gender inequality in workforce participation in the agriculture sector is easily visible. There is a high participation of women in some specific tasks and some others are recognized as male dominated work. However most of the female workforce is engaged in the agriculture sector only, it is seen unequally distributed in various operations. According to NSSO 68th round data, female participation in various agricultural operations is just 17% in Uttar Pradesh of India. The diverse socio-economic status of rural Uttar Pradesh affects participation in different ways. Female participation as agricultural laborer is high in lower caste and low in high caste societies here. Participation ratio is having an increasing trend from 01–14 to 30–44 years age groups, later declining to older age groups. It is increasing from small to medium-sized households, after which it has declined sharply. Almost half (46%) of the women participation in agricultural is coming from households which derive at least half of their income from their own farming. Education level and female participation is inversely associated. Participation is found highest in families with marginal size of land holdings (74.61%), followed by small (12.66%) and medium land holding size. The Principal Component Analysis (PCA) has been used to identify the key determinants for various operations. It has been found that household type, education level and size of land owned are most important among many other factors. This study will be helpful in suggesting ways to make the participation of women easier and more effective.
Optimism Persists when Walking in Unpredictable Environments
Authors: Bucklin Mary , Deol Jasjit , Brown Geoffrey , Perreault Eric , Gordon Keith 
Published: September 2022

Abstract
Humans continuously modulate their control strategies during walking based on their ability to anticipate disturbances. However, how people adapt and use motor plans to create stable walking in unpredictable environments is not well understood. Our purpose was to investigate how people adapt motor plans when walking in a novel and unpredictable environment. We evaluated the whole-body center of mass (COM) trajectory of participants as they performed repetitions of a discrete goal-directed walking task during which a laterally-directed force field was applied to the COM. The force field was proportional in magnitude to forward walking velocity and randomly directed towards either the right or left each trial. We hypothesized that people would adapt a control strategy to reduce the COM lateral deviations created by the unpredictable force field. In support of our hypothesis, we found that with practice the magnitude of COM lateral deviation was reduced by 28% (left) and 44% (right). Participants adapted two distinct unilateral strategies that collectively created a bilateral resistance to the unpredictable force field. These strategies included an anticipatory postural adjustment to resist against forces applied to the left, and a more lateral first step to resist against forces applied to the right. In addition, during catch trials when the force field was unexpectedly removed, participants exhibited trajectories similar to baseline trials. These findings were consistent with an impedance control strategy that provides a robust resistance to unpredictable perturbations. However, we also found evidence that participants made predictive adaptations in response to their immediate experience that persisted for three trials. Due to the unpredictable nature of the force field, this predictive strategy would sometimes result in greater lateral deviations when the prediction was incorrect. The presence of these competing control strategies may have long term benefits by allowing the nervous system to identify the best overall control strategy to use in a novel environment.