bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focus on the Speaker-Learner in English as a Global Language: Agency and Satisfaction
Authors:   University of Tübingen, Germany, Kohn Kurt 
Published: October 2022

In pedagogical debates about there ELT students are Global Englishes (GE) and English as a lingua franca (ELF), is widespread agreement concerning an urgent need for liberating teachers and students from the normative constraints of ELT’s orientation towards standard English by raising their awareness of the characteristics and complexities of GE/ELF communication. remedial education based on generally perceived as weak GE/ELF communicators requiring the analysis of recorded GE/ELF exchanges. Contrary to this deficit view, this article calls for acknowledging ELT students as ‘speaker-learners’, who are endowed with a natural capability for communication including strategic creativity, contextual inferencing, empathetic cooperativity, and communication monitoring. Through a as principal agents of ‘MY English’ development, guided by their personal communicative and communal success and their aspiration for speaker satisfaction. A social constructivist lens, they appear requirements of normalizing account of GE/ELF communication and an emancipatory MY English perspective on ELT provide the theoretical-conceptual underpinnings of an immersive pedagogical GE/ELF approach, preferably implemented through virtual exchange in a blended learning environment. Pedagogical mentoring is essential for helping students assume MY English responsibility, make best use of their ordinary communicative capability, and exploit the translanguaging range of their resources when faced with unfamiliar challenges in GE/ELF encounters.
PENGARUH LINGKUNGAN KERJA DAN PROMOSI JABATAN TERHADAP STRESS KERJA KARYAWAN PT. HIMAWAN PUTRA MEDAN.
Authors: Ivany Ivany , Syawaluddin Syawaluddin , Putra Aidil 
Published: October 2022

In creating a strong and successful company, a supportive work environment is needed and clear promotions are needed so that employees do not stress in carrying out work activities in the company. The purpose of this study was to determine the effect of the work environment and job promotions on Employee Stress at PT. Himawan Putra Medan.The research method used is a quantitative analysis method. The data used are primary andÂ secondary data. The study population was 50 people using saturated sampling techniques where all members of the population were sampled. Variables are measured with a Likert scale. The data analysis technique used is multiple linear regression.Based on simultaneous analysis of the work environment and job promotions affect the Employee Stress of PT. Himawan Putra Medan. Partially, there is an influence of work environment variables on employee work stress and there is an influence of job promotion on PT. Himawan Putra Medan. Â Keywords: Work Environment, Job Promotion, Employee Stress
PENGARUH KEPERCAYAAN MEREK DAN KEPUASAN KONSUMEN TERHADAP LOYALITAS MEREK PT ALFA SCORP II MARELAN MEDAN
Authors: Lindawaty Lindawaty , Syawaluddin Syawaluddin 
Published: October 2022

Loyal consumers are assets that are meaningful to the company, because in addition to consuming continuously they will also help to market the product to others, and as we know that marketing word of mouth (the word of mouth) is: the most marketing method effective and efficient. High consumer loyalty will certainly require a long time and a good strategy. The factors that will shape loyalty are brand trust and customer satisfaction. This study is to determine the effect of Brand Trust and Consumer Satisfaction on Brand Loyalty at PT. Alfa Scorpii Marelan both partially and simultaneously.This type of research is a quantitative descriptive method. The object of research in this study is the customer of PT. Alfa Scorpii Marelan totaling 150 people. The sampling technique uses the Slovin formula which produces a sample of 109 people, the data analysis technique used is multiple regression analysis, t-test, F-test, and coefficient of determination test.The results showed that partially and simultaneously brand trust and customer satisfaction affected their loyalty. Companies are advised to increase brand loyalty by increasing brand trust by approaching consumers and creating motorcycles with more interesting features and variations. In terms of customer satisfaction, companies are advised to open a suggestion box about customer satisfaction with Yamaha motorcycles. Companies are also advised to increase consumer confidence and safety in riding Yamaha motorbikes, overcome complaints related to Yamaha motorcycles such as durability and product reliability, improve service and establish good relationships with consumers in order to increase customer satisfaction so that Brand Loyalty increases.Â Keywords: Brand Trust, Consumer Satisfaction and Brand Loyalty
Molecular and Immunophenotypic Correlates of Metastatic Epithelioid Angiomyolipoma Include Alterations of TP53, RB1, and ATRX
Authors: McCarthy Michael R. , Nichols Paige E. , Sharma Vidit , Stanton Melissa L. , Reynolds Jordan P. , Pitel Beth A. , Halling Kevin C. , Lohse Christine M. , Herrera-Hernandez Loren , Thompson R. Houston , Leibovich Bradley C. , Jimenez Rafael E. , Boorjian Stephen A. , Cheville John C. , Gupta Sounak 
Published: October 2022

Context.—
Epithelioid angiomyolipomas (eAMLs) are rare tumors of the kidney that occur in patients with tuberous sclerosis complex or in a sporadic setting; a subset of these tumors exhibit metastatic behavior.

Objective.—
To analyze molecular profiling data to identify pathogenic alterations in rare cases of metastatic eAML, and to identify immunohistochemistry (IHC)-based surrogate markers.

Design.—
Molecular profiling data from the American Association for Cancer Research GENIE registry was accessed for 23 patients with angiomyolipomas, and 9 of 16 patients with eAMLs in our institutional registry were evaluated with next-generation sequencing. IHC was performed to screen for alterations of P53, RB, and ATRX for all 16 institutional cases.

Results.—
Combined alterations of 5 tumor-suppressor genes (TP53, ATRX, RB1, APC, and NF1) were identified using next-generation sequencing in 7 of 8 (88%) patients with metastatic disease compared to a single patient with nonmetastatic disease (RB1 variant of uncertain significance; 1 of 24, 4%). No cases with abnormal IHC results were identified in 11 patients with nonmetastatic disease compared to 3 of 5 patients with metastatic disease.

Conclusions.—
Our results show that the majority of metastatic eAMLs have mutations of 5 tumor-suppressor genes (TP53, ATRX, RB1, APC, and NF1), while these are rare in patients with nonmetastatic disease. Furthermore, IHC for P53, RB, and ATRX may serve as a screen for a subset of these alterations in resource-limited settings. These findings, if validated in larger data sets, have the potential to predict metastatic behavior in eAMLs.
Supraventricular Tachycardia (SVT) in Newborn Leading to a Hydrops Fetalis Syndrome: Case Report
Authors: Babour S. , Sellouti M. , Ayad A. , Saghir S. , Abilkassem R. , Agadr A. 
Published: October 2022

Hydrops fetalis is defined by the accumulation of fluids in the serous membranes (pleurisy, ascites, pericarditis...), it is a rare condition; its etiologies are divided into immunological and non-immunological. Supraventricular tachycardia remains a known cause, non-immunological, but difficult to manage.
In this article we report the case of a newborn with hydrops fetalis secondary to supraventricular tachycardia, which failed to be treated.
The clinical, paraclinical, etiological diagnosis and finally the treatment were discussed.
Causes and Constraints in Equine Rearing in Haryana, India
Authors: Singh Ajmer , Pal Yash , Prashad Jitender , Kumar Rajender , Kumar Sanjay 
Published: October 2022

Present study was aimed to identify causes and constraints in equine rearing in Haryana, India. The study was descriptive in nature and survey based. Structured interview schedule was adopted for data collection and data analysis was done by adopting Statistical Package for Social Sciences (SPSS) version. In current study, it emerged out that respondents are facing constraints in equine rearing and 9.9% responded that in-put cost is more and out-put cost is less in equine rearing and this is the prime cause, 10.2% mentioned that closure of equine fairs is major cause, 5.6% responded lack of government veterinary, 29.7% mentioned lack of work due to excessive use of automobile, 10.6% responded scarcity of financial help from government, 9.9% social taboo, 5.3% lack of enthusiasm among younger generation toward equine, 1.3% heavy traffic, expressways and fly-over, 0.7% re-occurrence of Glander disease in India and 15.8% are unable to say anything on causes and constraints for equine rearing in Haryana. As suggestions are concern, 42.4% respondents delineated in their feedback that loan facilities on subsidized rates should be made available to expand equine rearing business, 24.6% demanded expert government veterinary services, 6.6% adequate insurance facilities, 7.3% restart of equine fairs, 2% arrangement of adequate work for equines and 1.3% demanded that awareness camps for equine farmers by Haryana government authorities. The current study is very significant and will be helpful to visualize and address the situation in changed scenario.
Study: Use symptoms for benzo dosing in alcohol withdrawal
Authors: Knopf Alison 
Published: October 2022

Alcohol withdrawal symptoms are traditionally treated by benzodiazepines, often using a fixed‐dose protocol. A new study has found that using a symptoms‐triggered approach resulted in a lower rate of readmissions within 90 days and a reduced total dose of benzodiazepines. The study found that using a symptoms‐triggered approach does result in a longer length of hospital stay, but that this pays off for the patient and the payer in the long run. Using a symptoms‐triggered approach results in a reduced relapse to alcohol dependence, the study found.
Design Principles to Maximize Non‐Bonding States for Highly Tribopositive Behavior
Authors: Kim Jihye , Kang Donghyeon , Lee Hoo‐Kyung , Hwang Joon‐Ha , Lee Hyeon Yeong , Jeon Sera , Kim Dabin , Kim SeongMin , Kim Sang‐Woo 
Published: October 2022

AbstractThe development of highly tribopositive materials is crucial for realizing high‐performance triboelectric nanogenerators. In this study, a novel protocol to maximize the number of non‐bonding electrons with local dipoles for designing highly tribopositive materials is introduced, and nitrogen‐based dimethylol urea, diazolidinyl urea, and imidazolidinyl urea as promising tribopositive materials are suggested. The mechanism by which nitrogen‐based materials provide highly tribopositive properties is investigated using calculations based on density functional theory. Highly electronegative atoms, such as nitrogen and oxygen, attract electrons from neighboring atoms, resulting in the formation of negative local dipoles in the highest occupied molecular orbital band composed of non‐bonding electrons, thereby creating an electron‐donating environment. The proposed design protocol is confirmed by quantitatively investigating the triboelectric properties of nitrogen‐based materials, and analyzing the charge transfer characteristics of dimethylol urea based on dipole interactions.
Facet‐Dependent Intrinsic Activity of Single Co3O4 Nanoparticles for Oxygen Evolution Reaction
Authors: Liu Zhibin , Amin Hatem M. A. , Peng Yuman , Corva Manuel , Pentcheva Rossitza , Tschulik Kristina 
Published: October 2022

AbstractDeciphering the influence of nanocatalyst morphology on their catalytic activity in the oxygen evolution reaction (OER), the limiting reaction in water splitting process, is essential to develop highly active precious metal‐free catalysts, yet poorly understood. The intrinsic OER activity of Co3O4 nanocubes and spheroids is probed at the single particle level to unravel the correlation between exposed facets, (001) vs. (111), and activity. Single cubes with predominant (001) facets show higher activity than multi‐faceted spheroids. Density functional theory calculations of different terminations and reaction sites at (001) and (111) surfaces confirm the higher activity of the former, expressed in lower overpotentials. This is rationalized by a change in the active site from octahedral to tetrahedral Co and the potential‐determining step from *OH to *O for the cases with lowest overpotentials at the (001) and (111) surfaces, respectively. This approach enables the identification of highly active facets to guide shape‐selective syntheses of improved metal oxide nanocatalysts for water oxidation.
Biodegradable Carbon Dioxide‐Derived Non‐Viral Gene Vectors for Osteosarcoma Gene Therapy
Authors: Li Meirong , Lin Zheng‐Ian , Yang Jingyu , Huang Haoqiang , Liu Guan‐Lin , Liu Qiqi , Zhang Xinmeng , Zhang Ying , Xu Zhourui , Lin Haoming , Chai Yujuan , Chen Xin , Ko Bao‐Tsan , Liu Jia , Chen Chih‐Kuang , Yang Chengbin 
Published: October 2022

AbstractOsteosarcoma often occurs in children and adolescents with high invasiveness and high mortality. Polo‐like kinase 1 (PLK1) overexpressed in most tumors promotes cancer cell proliferation and transformation. PLK1 is considered as a therapeutic target for osteosarcoma. RNA interference‐based therapies are employed to combat osteosarcoma through silencing PLK1 gene expression. However, the treatment results remain unsatisfactory due to the lack of a safe and efficient nonviral gene vector. To tackle this hurdle, biodegradable and CO2‐derivative cationic poly(vinylcyclohexene carbonates) (CPCHCs) are used as gene vectors to perform a siPLK1 therapeutic strategy for osteosarcoma treatment. Of those CPCHCs, CPCHC60 demonstrates the most excellent performance in gene transfection efficiency, endo‐lysosome escaping, biodegradability, and biosafety. With the treatment of CPCHCs/siRNA nanoparticles, the expression level of PLK1 gene in osteosarcoma cells is significantly down‐regulated. Subsequently, cells are arrested in the G2/M phase and subsequently dead in the form of apoptosis, resulting in significant tumor regression both in vitro and in vivo. This study brings a new insight into the development of superior nonviral gene vectors for practical cancer treatment. Based on the results, the resulting nanoparticle‐based gene drug formation is considered to have a highly successful chance in further translational nanomedicine applications.
Approaching Bulk Mobility in PbSe Colloidal Quantum Dots 3D Superlattices
Authors: Pinna Jacopo , Mehrabi Koushki Razieh , Gavhane Dnyaneshwar S. , Ahmadi Majid , Mutalik Suhas , Zohaib Muhammad , Protesescu Loredana , Kooi Bart J. , Portale Giuseppe , Loi Maria Antonietta 
Published: October 2022

Abstract3D superlattices made of colloidal quantum dots are a promising candidate for the next generation of optoelectronic devices as they are expected to exhibit a unique combination of tunable optical properties and coherent electrical transport through minibands. While most of the previous work was performed on 2D arrays, the control over the formation of these systems is lacking, where limited long‐range order and energetical disorder have so far hindered the potential of these metamaterials, giving rise to disappointing transport properties. Here, it is reported that nanoscale‐level controlled ordering of colloidal quantum dots in 3D and over large areas allows the achievement of outstanding transport properties. The measured electron mobilities are the highest ever reported for a self‐assembled solid of fully quantum‐confined objects. This ultimately demonstrates that optoelectronic metamaterials with highly tunable optical properties (in this case in the short‐wavelength infrared spectral range) and charge mobilities approaching that of bulk semiconductor can be obtained. This finding paves the way toward a new generation of optoelectronic devices.
Lubrication Mechanism of Surface‐Attached Hydrogel Layers in Sliding Contact
Authors: Bahrami Maryam , Houérou Vincent Le , Rühe Jürgen 
Published: October 2022

AbstractSwollen, surface‐attached hydrogel layers in sliding contact exhibit unusual friction properties. To study this phenomenon, hydrogel layers covalently bonded to solid substrates are generated by CH insertion crosslinking. Brief UV irradiation of thin layers of photoreactive prepolymers leads to simultaneous crosslinking of the polymer chains and attachment of the network to the substrate. As the surface‐attached hydrogel layers can only swell perpendicular to the surface, and the polymer subchains on the two sides of the friction pair cannot interpenetrate for entropic reasons, adhesion in such friction pairs is negligible. In this work, the tribological behavior of surface‐attached hydrogel pairs is investigated as a function of load and sliding velocity. It is observed that for very thin films, the indentation and accordingly the friction is a strong function of the film thickness and the role of the chain confinement on the lubrication of surface‐attached hydrogels is discussed. A model for the friction mechanism of such systems is developed.
Unprecedented Thermo‐Enhanced Retainable Circularly Polarized Luminescence
Authors: Qi Weilin , Ma Cheng , Liao Peilong , Li Hongpeng , Gu Ting , Wu Tongyue , Huang Jianbin , Yan Yun 
Published: October 2022

AbstractCircularly polarized luminescence (CPL) enabled by chiral self‐assembly is very promising in diversified applications. However, temperature‐triggered disassembly or self‐assembly transition often results in reduction or even silence of CPL. Here, a strategy of coordinating self‐assembly is reported that offers temperature enhanced and retainable CPL that is resistant to further temperature variation. Upon co‐assembling commercial dyes with the coordinating hydrogel of cholate‐calcium, the chirality transfer from cholate to the dyes allows generation of CPL. With increasing temperature, the CPL intensity can be enhanced 4 times and the emission dissymmetry factorgemcan be promoted from 0.04 to 0.1, then they remain stable either upon further elevating or lowering temperature. Mechanism study reveals that increasing temperature has triggered the coordination transition between the carbonate groups and Ca2+from the metastable bidentate chelating to the thermal stable bridging mode, which drives the transition from flexible nanohelices to stiff helical bunches. This promotes the alignment of the dyes and in the meantime decreases its mobility, thus leads to increased CPL intensity andgem. It is envisioned that the strategy of coordinating self‐assembly would be very promising in creating thermally stable CPL for diversified applications.
Tandem Copper(I)‐Catalyzed N‐Arylation–1,4‐Conjugate Addition to Access Tetrahydroacridinones
Authors: Honnanayakanavar Jyoti M. , Behera Purna Chandra , Suresh Surisetti 
Published: October 2022

AbstractA copper‐catalyzed tandem process integrating N‐arylation and 1,4‐conjugate addition is disclosed through the reaction of cyclic enaminones and ortho‐halochalcones. The reaction appears to proceed through chemoselective arylation on the nitrogen of enaminone with ortho‐halochalcones and Michael addition of α‐carbon of the enaminone to the chalcone to furnish a diverse range of tricyclic tetrahydroacridinone derivatives in moderate to excellent yields.magnified image
Iron‐Catalyzed Radical Zincations of Alkyl Iodides
Authors: Sunagatullina Alisa S. , Lutter Ferdinand H. , Karaghiosoff Konstantin , Knochel Paul 
Published: October 2022

AbstractWe report a new iron‐catalyzed I/Zn‐exchange allowing to convert primary or tailored secondary alkyl iodides into the corresponding alkylzinc iodides. In the presence of a remote double bond at position 5, diastereoselective ring closures are observed. Quenching of these zinc reagents, after transmetalation to copper species (with CuCN ⋅ 2LiCl) or under Pd‐catalysis, with typical electrophiles (allyl bromides, acid chlorides or aryl iodides) gave various polyfunctional products.magnified image
Epstein–Barr Virus‐Encoded MicroRNA‐BART18‐3p Promotes Colorectal Cancer Progression by Targeting De Novo Lipogenesis
Authors: Meng Qingtao , Sun Hao , Wu Shenshen , Familiari Giuseppe , Relucenti Michela , Aschner Michael , Li Xiaobo , Chen Rui 
Published: October 2022

AbstractThe Epstein–Barr virus (EBV) genome encodes a cluster of 22 viral microRNAs, called miR‐BamHI‐A rightward transcripts (miR‐BARTs), which are shown to promote the development of cancer. Here, this study reports that EBV‐miR‐BART18‐3p is highly expressed in colorectal cancer (CRC) and is closely associated with the pathological and advanced clinical stages of CRC. Ectopic expression of EBV‐miR‐BART18‐3p leads to increased migration and invasion capacities of CRC cells in vitro and causes tumor metastasis in vivo. Mechanistically, EBV‐miR‐BART18‐3p activates the hypoxia inducible factor 1 subunit alpha/lactate dehydrogenase A axis by targeting Sirtuin, which promotes lactate accumulation and acetyl‐CoA production in CRC cells under hypoxic condition. Increased acetyl‐CoA utilization subsequently leads to histone acetylation of fatty acid synthase and fatty acid synthase‐dependent fat synthesis, which in turn drives de novo lipogenesis. The oncogenic role of EBV‐miR‐BART18‐3p is confirmed in the patient‐derived tumor xenograft mouse model. Altogether, the findings define a novel mechanism of EBV‐miR‐BART18‐3p in CRC development through the lipogenesis pathway and provide a potential clinical intervention target for CRC.
Simultaneous Recognition and Separation of Organic Isomers Via Cooperative Control of Pore‐Inside and Pore‐Outside Interactions
Authors: Xue Shaomin , Rong Yujia , Ding Ning , Zhao Chaofeng , Sun Qi , Li Shenghua , Pang Siping 
Published: October 2022

AbstractDespite the desirability of organic isomer recognition and separation, current strategies are expensive and complicated. Here, a simple strategy for simultaneously recognizing and separating organic isomers using pillararene‐based charge‐transfer cocrystals through the cooperative control of pore‐inside and pore‐outside intermolecular interactions is presented. This strategy is illustrated using 1‐bromobutane (1‐BBU), which is often produced as an isomeric mixture with 2‐bromobutane (2‐BBU). According to its structure, perethylated pillar[5]arene (EtP5) and 3,5‐dinitrobenzonitrile (DNB) are strategically chosen as a donor and an acceptor. As a result, their cocrystal exhibited stronger pore‐inside interactions and much weaker pore‐outside interactions with 1‐BBU than with 2‐BBU. Consequently, nearly 100% 1‐BBU selectivity is achieved in two‐component mixtures, even in those containing trace 1‐BBU (1%), whereas free EtP5 only achieved 89.80% selectivity. The preference for linear bromoalkanes is retained in 1‐bromopentane/3‐bromopentane and 1‐bromohexane/2‐bromohexane mixtures, demonstrating the generality of this strategy. Selective adsorption of linear bromoalkanes induced a naked‐eye‐detectable color change from red to white. Moreover, the cocrystal are used over multiple cycles without losing selectivity.