bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Medical Genetics Into Precision Oncology Practice in the Veterans Health Administration: The Time Is Now
Authors: Scott Anthony , Mohan Arathi , Austin Sarah , Amini Erika , Raupp Shelby , Pannecouk Brittany , Kelley Michael J. , Narla Goutham , Ramnath Nithya 
Published: March 2022

PURPOSE:Increased access and utilization of tumor profiling of cancers in our veteran population uncovered a modest number of potentially pathogenic germline variants (PPGVs) that require genetics referral for follow-up evaluation and germline sequencing. Challenges identified specific to the veteran population include paucity of genetics providers, either at a veteran's VA facility or nearby non-VA facilities. We sought to investigate the number of veterans who would benefit from having such resources at both local and national levels.METHODS:Annotated clinical reports of mutations identified by tumor-only profiling and medical records of veterans with solid tumors at the Veterans Administration Ann Arbor Healthcare System (VA AAHS) between 2015 and 2020 were reviewed. PPGVs were identified according to society recommendations (such as ESMO and American Board of Medical Genetics and Genomics), expert review, and/or previously published criteria. After the analysis of our local VA population, these same criteria were then applied to veterans in the National Precision Oncology Program (NPOP).RESULTS:Two hundred eight veterans underwent tumor profiling at the VA AAHS over the defined time period. This included 20 different primary tumor sites with over half (n = 130) being advanced cancer at diagnosis. Of these, 18 veterans (8.5%) had mutations suggestive of a PPGV. Applying these criteria to the larger NPOP database (n = 20,014), a similar percentage (6%) of PPGVs were identified.CONCLUSION:These results indicate a PPGV frequency (6%-9% of veterans) consistent with the prevalence of inherited cancer predisposition syndromes in the general population, underscoring the need for medical genetics as part of standard oncologic care for veterans. We explore current and future care delivery models to optimize incorporation of medical genetics and genetic counseling to best serve veterans needing such services.
Quantification analysis of fuzzy recurrence plots
Authors: Pham Tuan D. 
Published: March 2022

Abstract
The method of fuzzy recurrence plots has been introduced as an extension of the method of recurrence plots to display recurrences of the reconstructed phase-space trajectories of dynamical systems as grayscale images. This paper presents some quantifiable measures of fuzzy recurrence plots in the context of the recurrence quantification analysis.
Phylogenetics of swimming behaviour in Medusozoa: the role of giant axons and their possible evolutionary origin
Authors: Meech Robert W. 
Published: March 2022

ABSTRACT
Although neural tissues in cnidarian hydroids have a nerve net structure, some cnidarian medusae contain well-defined nerve tracts. As an example, the hydrozoan medusa Aglantha digitale has neural feeding circuits that show an alignment and condensation, which is absent in its relatives Aequorea victoria and Clytia hemisphaerica. In some cases, neural condensations take the form of fast propagating giant axons concerned with escape or evasion. Such giant axons appear to have developed from the fusion of many, much finer units. Ribosomal DNA analysis has identified the lineage leading to giant axon-based escape swimming in Aglantha and other members of the Aglaura clade of trachymedusan jellyfish. The Aglaura, along with sister subclades that include species such as Colobonema sericeum, have the distinctive ability to perform dual swimming, i.e. to swim at either high or low speeds. However, the form of dual swimming exhibited by Colobonema differs both biomechanically and physiologically from that in Aglantha and is not giant axon based. Comparisons between the genomes of such closely related species might provide a means to determine the molecular basis of giant axon formation and other neural condensations. The molecular mechanism responsible may involve ‘fusogens’, small molecules possibly derived from viruses, which draw membranes together prior to fusion. Identifying these fusogen-based mechanisms using genome analysis may be hindered by the many changes in anatomy and physiology that followed giant axon evolution, but the genomic signal-to-noise ratio may be improved by examining the convergent evolution of giant axons in other hydrozoa, such as the subclass Siphonophora.
Molecular evidence of intertidal habitats selecting for repeated ice-binding protein evolution in invertebrates
Authors: Box Isaiah C. H. , Matthews Benjamin J. , Marshall Katie E. 
Published: March 2022

ABSTRACT
Ice-binding proteins (IBPs) have evolved independently in multiple taxonomic groups to improve their survival at sub-zero temperatures. Intertidal invertebrates in temperate and polar regions frequently encounter sub-zero temperatures, yet there is little information on IBPs in these organisms. We hypothesized that there are far more IBPs than are currently known and that the occurrence of freezing in the intertidal zone selects for these proteins. We compiled a list of genome-sequenced invertebrates across multiple habitats and a list of known IBP sequences and used BLAST to identify a wide array of putative IBPs in those invertebrates. We found that the probability of an invertebrate species having an IBP was significantly greater in intertidal species than in those primarily found in open ocean or freshwater habitats. These intertidal IBPs had high sequence similarity to fish and tick antifreeze glycoproteins and fish type II antifreeze proteins. Previously established classifiers based on machine learning techniques further predicted ice-binding activity in the majority of our newly identified putative IBPs. We investigated the potential evolutionary origin of one putative IBP from the hard-shelled mussel Mytilus coruscus and suggest that it arose through gene duplication and neofunctionalization. We show that IBPs likely readily evolve in response to freezing risk and that there is an array of uncharacterized IBPs, and highlight the need for broader laboratory-based surveys of the diversity of ice-binding activity across diverse taxonomic and ecological groups.
Synthesis of NHC Ligands Containing a Sulfoxide Moiety and Their Use in Cross-Coupling via a Au(I)/(III) Catalytic Cycle
Authors: Shibata Takanori , Nagai Rikako , Okazaki Sari , Nishibe Shun , Ito Mamoru 
Published: March 2022

Abstract
We designed and synthesized a new series of NHCs with a sulfoxide moiety as a hemilabile ligand. We investigated the catalytic activities of Au(I)-NHC complexes in the strong oxidant-free cross-coupling of iodoarenes with 1,3,5-trimethoxybenzene. We ascertained that the sulfoxide moiety is critical for the Au(I)/(III) catalytic cycle.
Synthesis of 1H-2-Benzopyran-5,8-dione Skeleton through a Cascade Reaction between Benzoquinone and β-Ketoester
Authors: Nakahara Masataka , Ohtsu Hiroyoshi , Kawano Masaki , Hanaya Kengo , Sugai Takeshi , Higashibayashi Shuhei 
Published: March 2022

Abstract
The 1H-2-benzopyran-5,8-dione structure was synthesized by a cascade reaction through Michael addition, elimination of HBr, and O-alkylation between a dibromobenzoquinone derivative and β-ketoesters under basic conditions. The reaction using potassium carbonate and 18-crown-6 in THF was the best condition, giving 1H-2-benzopyran-5,8-dione derivatives in good yields. The UV-vis absorption spectrum and cyclic voltammogram of the synthesized 1H-2-benzopyran-5,8-dione derivative were measured, clarifying the photophysical and redox properties.
B-type natriuretic peptide as diagnostic and prognostic marker in various forms of acute coronary syndrome
Authors: Sadiq Sidra , Ijaz Aamir , Dawood Mirza Muhammad , Sadiq Tayyaba 
Published: March 2022

Objectives: This study was conducted to evaluate the diagnostic and prognostic value of B-type natriuretic peptide (BNP) in different categories of acute coronary syndrome (ACS) patients on arrival.
Methods: This cohort study included 197 patients admitted in Coronary Care Unit (CCU) of Rehman Medical Institute (RMI) Peshawar from January 2020 to June 2020. Patients were categorized in two subgroups. Subgroup-I with BNP below 100pg/mL. Subgroup-II having BNP above 100pg/mL. Samples were obtained on admission from these patients for Cardiac Troponin I (Trop-i), BNP and serum creatinine. BNP samples were analyzed on Cobas® using chemiluminescence method. Descriptive statistics were derived for age; gender and cardiac biomarkers. Receiver-operating characteristic curves (ROC) were generated. Diagnostic accuracy parameters were determined for Non ST- segment elevation myocardial infarction (STEMI), ST- segment elevation myocardial infarction (STEMI) and unstable angina (UA).
Result: One hundred fourteen patients (58.2%) were males and 82 were females (41.8%).Our of this 89 patients were NSTEMI in group II. Mean BNP was 1438±1463.Age distribution shows 120 individuals were over 55 years (61.2%). Hypertension, diabetes, smoking and previous infarcts were the risk factors for ACS. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive value (NPV), likelihood ratios, and overall accuracy of BNP at admission for the entire sub categories in ACS (cut-off value 100 pg/mL) were determined by using Trop-i the gold standard. ROC curve showed AUC = 0.557, (95% confidence interval: 0.476–0.638). When Pearson correlation was applied, BNP was found to be a noteworthy independent predictor.
Conclusion: BNP can be a useful Biomarker along with standard cardiac biomarkers in various categories of patients with ACS.
doi: https://doi.org/10.12669/pjms.38.4.4910
How to cite this:Sadiq S, Ijaz A, Dawood MM, Sadiq T. B-type natriuretic peptide as diagnostic and prognostic marker in various forms of acute coronary syndrome. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.4910
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Inter-rater reliability of pressure biofeedback unit among individuals with and without chronic low back pain
Authors: Khan Muhammad , Zafar Hamayun , Gilani Syed Amir 
Published: March 2022

Objectives: To determine the inter-rater reliability of pressure biofeedback unit among individuals with and without chronic low back pain.
Methods: This cross-sectional survey was conducted from February 2021 to March 2021 at the Physiotherapy Department of the Sindh Institute of Physical Medicine and Rehabilitation. Sixteen subjects which were recruited with and without chronic low back pain.(CLBP). During the test, abdominal drawing in movement was monitored by measuring a change in pressure detected in PBU. Each test was performed once by two trained assessors with period of seven days. Reliability indices of Pressure Biofeedback (PBU) measures including the Intraclass correlation coefficient [ICC] and Band Altman plot were analyzed.
Results: This study found an intra-class correlation coefficient (ICC) = 0.94 [95% confidence interval (CI) (0.37, 0.99] for inter-rater reliability in healthy individuals, and an ICC of 0.97 (95% CI 0.97, 0.98) for inter-rater reliability in CLBP. The interrater agreement (Limits of Agreement–LOA=5.92, -3.9 mmHg) in CLBP and the interrater agreement (LOA=5.75, -3.25 mmHg) in healthy individuals were within the limits of agreement on 95% of occasions.
Conclusion: Pressure Biofeedback Unit has showed excellent inter-rater reliability in measuring Transverse Abdominis muscle activity for individuals with and without chronic LBP.
doi: https://doi.org/10.12669/pjms.38.4.4952
How to cite this:Khan M, Zafar H, Gilani SA. Inter-rater reliability of pressure biofeedback unit among individuals with and without chronic low back pain. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.4952
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Depression, Anxiety and Stress among nursing officers in a dedicated hospital for COVID patients in Sri Lanka: A Single Institute Experience
Authors: Pathiraja Pathirajage Deepthi Madushan , Srikanthi Wallagoda Samantha , Jayamanne Bernard Deepal Wanniarachchi , DeSilva Hewage Sanduni 
Published: March 2022

The main objective of this study was to assess the prevalence of stress, anxiety and depression, among nurses working in a tertiary hospital dedicated to the COVID-19 patients in Sri Lanka. A cross-sectional study was carried out among nurses working at Colombo East Base Hospital. The data was collected using a self-administered questionnaire and DASS-21, a set of three self-report scales designed to measure the negative emotional states of depression, anxiety, and stress over three months from October 2020. Data were analysed applying descriptive statistics and inferential statistical methods. There was a total of 131 study participants (response rate 83 %), and most of them were working in general wards (56%), while 42% were in critical care units. The proportion of anxiety and stress is associated with nurses working in critical care units were significantly higher than those in general wards (p<0.001). There were no associations between sex, marital status, having children, experience, qualifications, and medical or psychiatric conditions (p>0.05). The system of reporting mental health issues was unfortunately not in place. Staff felt that reporting stress/burnout or anxiety might seem like a negative attribute. Considering the above factors, one would expect more prevalence than we have seen in this study; therefore, we can infer that if mental health is not prioritised in healthcare institutions, then definitely lack of awareness/openness and under-reporting by staff will result in a long-term systemic problem (Suffering in the name of Resilience).
doi: https://doi.org/10.12669/pjms.38.4.5508
How to cite this:Pathiraja PDM, Srikanthi WS, Jayamanne BDW, DeSilva HS. Depression, Anxiety and Stress among nursing officers in a dedicated hospital for COVID patients in Sri Lanka: A Single Institute Experience. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.5508
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ameliorative effect of gel combination of Centella asiatica extract transfersomes and rosemary essential oil nanoemulsion against UVB-induced skin aging in Balb/c mice
Authors: Khotimah Husnul , Dewi Lestari Ismail Dina , Widasmara Dhelya , Riawan Wibi , Retnaningtyas Ekowati , Weka Nugraheni Raditya , Eka Puspita Oktavia , Rahayu Adianingsih Oktavia , Mardiyah Mardiyah , Setiawan Andri 
Published: March 2022

Background: Ultraviolet B (UVB) radiation induces physiological and morphological photoaging of the skin resulting in wrinkles, and loss of elasticity. This study analyzed nanoencapsulation of a gel combination of Centella asiatica (CA) transfersomes and rosemary essential oil (REO) nanoemulsion with lipid-based nanocarriers for the ability of both biological compounds to synergistically prevent UVB radiation, along with ameliorative and anti-aging effects. Methods: To ensure the quality, lipid-based nanocarriers of transfersomes and nanoemulsion were characterized based on physicochemical properties such as particle size distribution, polydispersity index, zeta potential. In vivo studies were used to determine the biological effects of a gel combination of CA transfersomes, and REO nanoemulsion applied topically two weeks before UVB radiation (840 mJ/cm2) in BALB/c hairless mice. Results: Results showed that the optimum lipid-based nanocarriers had a particle size of 43.97 ± 5.6 nm, a polydispersity index of 0.64 ± 0.01, and a zeta potential of -10.91 ± 1.99 mV. In vivo experiments revealed that topical application of a gel combination of CA transfersomes and REO nanoemulsion significantly ameliorated wrinkle formation, epidermal hyperplasia, and collagen fiber arrangement caused by UVB exposure. Further, the gel combining CA transfersomes and REO nanoemulsion suppressed lipid peroxidation by decreasing the expression of malondialdehyde (MDA) and collagen destruction by inhibiting matrix metalloproteinase-9 (MMP-9) expression. Moreover, the gel combination of CA transfersomes and REO nanoemulsion upregulated type I collagen through activation of the transforming growth factor-β (TGF-β)/Smad pathway, thereby recovering the density of collagen fiber reduced by UVB radiation. Conclusions: Overall, these data indicate that topical application of a gel combination of CA transfersomes and REO nanoemulsion could act synergistically and potentially prevents oxidative stress and collagen degradation in the skin from UVB-induced photoaging.
Tajemniczy napis z obrazu Matki Boskiej Ormiańskiej w Kamieńcu Podolskim
Authors: Pisowicz Andrzej 
Published: March 2022

Mysterious writing from the picture of the Armenian Mother of God in Kamieniec Podolski (Kamianets-Podilskyi)
The author, on the basis of Jacek Chrząszczewski’s publications, corrects reading of the writing left on the miraculous picture of the Kamieniec Mother of God from the Armienian church of St Nicholas in Kamieniec Podolski (Kamianets- Podilskyi), made by editors of the recent German translation of Minas Bzhshkyants’ work Podróż do Polski [Journey to Poland] dated at 1830.
What the Past Tells About the Future: Historical Prices in the Durable Goods Market
Authors: Gong Zheng , Huang Jin , Chen Yuxin 
Published: March 2022

We investigate how historical price information (e.g., accessed through price trackers) influences consumers’ purchase decisions and thus affects a firm’s dynamic pricing strategy. We first show that when consumers with heterogeneous tastes are not informed about historical prices, the monopolist charges a high regular price for most of the time and periodically holds low-price sales. Then we consider the case in which a small fraction of consumers (such as price tracker users) become informed of historical prices. At the new equilibrium, the monopolist lowers the regular price and advances sales, implying shorter price cycles, more frequent sales, and a positive spillover effect of price tracker users’ informational advantage on the rest of uninformed consumers. We conclude with a discussion of the impact of price trackers on firms and other relevant managerial implications of the model. This paper was accepted by Dmitri Kuksov, marketing. Funding: Y. Chen thanks the National Science Foundation of China [Grant 71972043] for the support. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4309 .
Social Skills Improve Business Performance: Evidence from a Randomized Control Trial with Entrepreneurs in Togo
Authors: Dimitriadis Stefan , Koning Rembrand 
Published: March 2022

Recent field experiments demonstrate that advice, mentorship, and feedback from randomly assigned peers improve entrepreneurial performance. These results raise a natural question: what is preventing entrepreneurs and managers from forming these peer connections themselves? We argue that entrepreneurs may be under-networked because they lack the necessary social skills—the ability to communicate effectively and interact collaboratively with new acquaintances—that allow them to match efficiently with knowledgeable peers. We use a field experiment in the context of a business training program in Togo to test if a short social skills training module increases the number and complementarity of peers that participants choose to learn from. We find that social skills training led entrepreneurs to match with 50% more peers and that more of those matches were based on complementary managerial skill. Finally, the training also increased entrepreneurs’ monthly profits by approximately 20%. Further analyses point to improvements in networking and advice as the drivers of performance improvements. Our findings suggest that social skills help entrepreneurs build relationships that create value for both themselves and their peers. This paper was accepted by Alfonso Gambardella, business strategy. Funding: This work was supported by the Ewing Marion Kauffman Foundation [Dissertation Fellowship] and the Strategic Management Society [SRF Dissertation Fellowship]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4334 .
A herança marioandradiana: fonte de inspiração para pesquisas decolonizadoras
Authors: Paula Roberta Cristina de 
Published: March 2022

Este artigo apresenta os entrelaçamentos entre os meus trabalhos de conclusão de Curso, respectivamente a Graduação, o Mestrado e Doutorado em Educação (PAULA 2003; 2012; 2019), com o objetivo de pensar a Pedagogia da Infância para além dos espaços educacionais formais. Destaco que uma das premissas dos desdobramentos destes estudos foi a obra da pesquisadora Ana Lúcia Goulart de Faria (2002), sobre os Parques Infantis da capital paulista de 1935 a 1938, proposta essa implementada por Mário de Andrade, então diretor do Departamento de Cultura de São Paulo. Os três trabalhos por mim elaborados são de caráter qualitativo, sendo que as metodologias empregadas foram pesquisa histórica, bibliográfica e uma etnografia. As investigações tiveram como principais campos teóricos a Pedagogia, os Estudos Sociais da Infância, e a Antropologia. Como ponto de convergência, os dados produzidos mostram que a linguagem corporal é uma das mais importantes formas de expressão, e que as manifestações das culturas populares, como a dança, a música e o canto são potencializadores dessa linguagem.
Omnidirectional 3D autostereoscopic aerial display with continuous parallax
Authors: Zhang Nan , Huang Tianqi , Zhang Xinran , Hu Chengquan , Liao Hongen 
Published: March 2022

We present anl omnidirectional 3D autostereoscopic aerial display with continuous parallax. Integral photography (IP) combined with polyhedron-shaped aerial imaging plates (AIPs) is utilized to achieve an extended view angle of 3D aerial images. With optical theoretical analysis and an aerial in situ rotation design, a 3D aerial display with an enlarged viewing angle is realized. In particular, the proposed 3D aerial display can realize any assigned angle within 360 deg. We also optimize the aerial display with artifact image removal and floating image brightness analysis. Experiments are performed to prove the 3D aerial display with full-motion parallax, continuous viewpoints, and multiplayer interaction. The proposed system is an attractive prospect of non-contact interaction and multi-person collaboration.