bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐admitted technical debt detection by learning its comprehensive semantics via graph neural networks
Authors: Li Hui , Qu Yang , Liu Yong , Chen Rong , Ai Jun , Guo Shikai 
Published: June 2022

AbstractThe goal of software development is to deliver software products with high quality and free from defects, but resource and time constraints often cause the developers to submit incomplete or temporary patches of codes and further bear the additional burden. Therefore, the investigations on identifying self‐admitted technical debt (SATD) to improve code quality have been conducted in recent years. However, missing syntactic structure information and the imbalance distribution bias shorten the SATD identification performance. Addressing to this issue, we present a graph neural network based SATD identification model (GNNSI) to improve the performance. Specifically, we obtain the structure information of the missing SATD in a compositional way to obtain different feature maps for different comments, and use focal loss to handle the imbalance between SATD and non‐SATD classes in the comments. Then extensive experiments on 10 open source projects are conducted, and the results show that GNNSI outperforms the baselines and can help developers to better predict SATDs.
Modeling the correlation between the workload and the power consumed by a server using stochastic and non‐parametric approaches
Authors: El Motaki Saloua , Yahyaouy Ali , Gualous Hamid 
Published: June 2022

AbstractIn this article, we address a critical concern of the growth of computer servers number and the resulting power expenditures in data centers by analyzing the statistical metrics related to the workload executed in each physical node. The aim is to build a stochastic model for power consumption estimation based on historical data. Relying on in‐depth investigation and experimental testing of the power consumption features and performance of the various workload datasets, we propose a model that considers the workload and the power consumed to be executed by a server as random variables. Based on the properties of the probabilistic distribution function of each random variable, we establish the correlation relationship between the workload and the power consumption using a non‐parametric approach. Our use of a non‐parametric method to learn a given probability model is challenging because it requires estimating the full distribution from the available data samples. The accuracy of our approach is demonstrated by estimating the energy consumption of various workloads. The experimental and simulation results show that our model outperforms many existing approaches in terms of accuracy, and it can be applied to a wide variety of workloads.
Starches Properties from Soft, Medium‐Hard, and Hard Brazilian Wheat upon Annealing
Authors: Biduski Bárbara , Werlang Stefani , Colussi Rosana , Pinto Vania Zanella , Zavareze Elessandra da Rosa , Gutkoski Luiz Carlos , Bertolin Telma Elita 
Published: June 2022

AbstractWheat kernel hardness is influenced by starch and protein association into the wheat grain. Therefore, starch properties may differ and result in different properties after physical modification. Starches isolated from hard, medium‐hard, and soft Brazilian wheat are modified by annealing and evaluated by physicochemical, pasting and thermal properties, and crystallinity. Soft and hard wheat starches have the highest amylose content and are not influenced by annealing treatment. Relative crystallinity is higher in medium‐hard wheat starch due to the lowest amylose content. However, it is not influenced by annealing treatment. In contrast, soft and hard wheat starches increase the relative crystallinity after annealing. Moreover, annealing reduces the pasting properties profile of all starches by decreasing viscosity (peak and final), breakdown, and setback; consequently, gel texture is also reduced. A decrease in swelling power is also noticed after annealing treatment. Wheat kernel hardness has influenced into properties of both native and annealed starches.
Long‐read‐based draft genome sequence of Indian black gram IPU‐94‐1 ‘Uttara’: Insights into disease resistance and seed storage protein genes
Authors: Ambreen Heena , Oraon Praveen Kumar , Wahlang Daniel Regie , Satyawada Rama Rao , Katiyar‐Agarwal Surekha , Agarwal Manu , Jagannath Arun , Kumar Amar , Budhwar Roli , Shukla Rohit Nandan , Goel Shailendra 
Published: June 2022

AbstractBlack gram [Vigna mungo (L.) Hepper var. mungo] is a warm‐season legume highly prized for its protein content along with significant folate and iron proportions. To expedite the genetic enhancement of black gram, a high‐quality draft genome from the center of origin of the crop is indispensable. Here, we established a draft genome sequence of an Indian black gram cultivar, ‘Uttara’ (IPU 94‐1), known for its high resistance to mungbean yellow mosaic virus. Pacific Biosciences of California, Inc. (PacBio) single‐molecule real‐time (SMRT) and Illumina sequencing assembled a draft reference‐guided assembly with a cumulative size of ∼454.4 Mb, of which, 444.4 Mb was anchored on 11 pseudomolecules corresponding to 11 chromosomes. Uttara assembly denotes features of a high‐quality draft genome illustrated through high N50 value (42.88 Mb), gene completeness (benchmarking universal single‐copy ortholog [BUSCO] score 94.17%) and low levels of ambiguous nucleotides (N) percent (0.0005%). Gene discovery using transcript evidence predicted 28,881 protein‐coding genes, from which, ∼95% were functionally annotated. A global survey of genes associated with disease resistance revealed 119 nucleotide binding site–leucine rich repeat (NBS‐LRR) proteins, while 23 genes encoding seed storage proteins (SSPs) were discovered in black gram. A large set of microsatellite loci were discovered for marker development in the crop. Our draft genome of an Indian black gram provides the foundational genomic resources for the improvement of important agronomic traits and ultimately will help in accelerating black gram breeding programs.
Implications of fetal premature atrial contractions: systematic review
Authors: Bet B. B. , De Vries J. M. , Limpens J. , Van Wely M. , Van Leeuwen E. , Clur S. A. , Pajkrt E. 
Published: June 2022

ABSTRACTObjectiveFetal heart‐rate irregularities occur in 1–2% of pregnancies and are usually caused by premature atrial contractions (PAC). Although PAC are considered benign, they may be associated with cardiac defects and tachyarrhythmia. We aimed to determine the incidence of congenital heart defects (CHDs) and complications in fetuses with PAC.MethodsThis was a systematic review and meta‐analysis conducted in accordance with the PRISMA statement for reporting items for systematic reviews and meta‐analyses. MEDLINE and EMBASE were searched from 1990 to June 2021 to identify studies on fetuses with PAC. The primary outcome was CHD; secondary outcomes were complications using the endpoints supraventricular tachyarrhythmia (SVT), cardiac failure and intrauterine fetal demise. Meta‐analysis of proportions was performed, subdivided into high‐risk and low‐risk populations based on reason for referral. Pooled incidences with 95% CIs were calculated.ResultsOf 2443 unique articles identified, 19 cohort studies including 2260 fetuses were included. The pooled incidence of CHD in fetuses with PAC was 2.8% (95% CI, 1.5–4.1%), when 0.6% is the incidence expected in the general population. The pooled incidence of CHD was 7.2% (95% CI, 3.5–10.9%) in the high‐risk population and 0.9% (95% CI, 0.0–2.0%) in the low‐risk population. SVT occurred in 1.4% (95% CI, 0.6–3.4%) of fetuses diagnosed with PAC. Cardiac failure was described in 16 fetuses (1.4% (95% CI, 0.5–3.5%)), of which eight were CHD‐related. Intrauterine fetal demise occurred in four fetuses (0.9% (95% CI, 0.5–1.7%)) and was related to CHD in two cases.ConclusionsOur findings suggest that the risk of CHD in fetuses with PAC is 4–5 times higher than that in the general population. CHD was present more frequently in the high‐risk population. Consequently, an advanced ultrasound examination to diagnose PAC correctly and exclude CHD is recommended. Complications of PAC are rare but can result in fetal demise, thus weekly fetal heart‐rate monitoring remains advisable to enable early detection of SVT and to prevent cardiac failure. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Monitoring of aquatic birds and surveillance of avian influenza and Newcastle disease of waterfowls at the National Park of Urmia Lake
Authors: Dehgany‐Asl Saied , Allymehr Manoochehr , Talebi Alireza , Yosefi Omid , Allahyari Esmaeel 
Published: June 2022

AbstractBackgroundUrmia lake, as a national park, is one of the most valuable aquatic ecosystems in the Middle East and quatitative and qualitative changes in Urmia lake water have a great impact on its ecological performance and in the region.ObjectivesThis project was designed to study the effects of the extent of Urmia lake water surface area on the area size and on the number of aquatic birds of the six selected habitats in 2011–2019. The presence of avian influenza (AI) and Newcastle disease (ND) viruses in migratory aquatic birds together with their impacts on poultry farms as well as on rural birds was also under surveillance in 2018–2019.MethodsChanges of Urmia lake and its impacts on area size of the six selected birds habitats were monitored by GIS. The small monitoring program with circular plot point counts was used for counting of the number of birds of the six selected habitats. At least, 100 samples (oropharyngeal and cloacal swabs) were collected. each sample was placed in a sterile plastic tube containg transport media and assigned with an number and store untill used. Reverse transcription‐polymerase chain reaction (RT‐PCR) and real‐time RT‐PCR test were used for detection of AI and ND viruses in the samples.ResultsThe results revealed that changes in the water surface area of Urmia lake had a gsignificat impacts on area size and the number of aquatic birds of the six selected habitats. The surveillance results showed that 5% of the samples were AIV positvie while 25% of the samples were pasitive for NDV including 20% for non‐virulent NDV (lNDV) and 5% for virulent NDV (vNDV) strains.ConclusionThis study showed that fluctuation of Urmia lake's water surface area influenced (p < 0.05) the area size of the six selected aquatic birds' habitats and had a great impacts on the number of the migratory birds. Detection of AIV and vNDV emphesises that the seasonal migratory waterfowls spread AI and vND viruses to the ponds and estuaries as well as to the rural birds and industrialised poultry units around the Urmia lake. Potential public health treats were also discussed.
Fungal rhinosinusitis caused byScedosporium apiospermumin a dog in the United Kingdom
Authors: Natsiopoulos Thomas , Rasotto Roberta , Housley Daniel , Valls Sanchez Ferran 
Published: June 2022

AbstractA 10‐year‐old, male, neutered Irish Terrier dog, weighing 16.2 kg, was presented for further investigation of unilateral nasal discharge of 6‐month duration. The patient was on long‐term treatment with prednisolone. Computed tomography of the head showed severe chronic erosive rhinitis and severe periodontal disease. On anterograde rhinoscopy, multiple plaque‐like lesions were identified throughout the nasal cavity with evidence of severe turbinate destruction. Cytology, histopathology and fungal culture of these lesions confirmed fungal rhinitis attributable toScedosporium apiospermuminfection. A possible causal relationship between periodontal disease and fungal rhinitis remains unknown. To the authors’ knowledge, this is the first reported case of fungal rhinitis caused by this particular agent in the United Kingdom.
Gastrointestinal obstruction secondary to seminal vesicle cystic hyperplasia in an African pygmy hedgehog (Atelerix albiventris)
Authors: Wooten McCaide T. , Snider Timothy A. 
Published: June 2022

AbstractA 3‐year‐old, male, entire African pygmy hedgehog (Atelerix albiventris) was presented for a 10‐day history of hyporexia, mucoid green faeces and lethargy. Survey radiographs revealed a left caudal abdominal mass effect with cranial displacement and gas distension of the intestinal loops. During exploratory laparotomy, the cause of the mass effect was revealed to be grossly enlarged seminal vesicles, which were excised. Histopathology revealed uniform polycystic glandular architecture, consistent with benign cystic hyperplasia. The patient recovered and was clinically healthy at the last follow‐up examination. This is the first detailed report describing the antemortem diagnosis of benign seminal vesicular cystic hyperplasia resulting in presumptive clinical gastrointestinal disease in an African pygmy hedgehog.
Transcultural Flow in the Age of Globalization: Digital Platforms, Fandom and Mediated Culture in South Asia
Authors: Roy Ratan Kumar , Das Biswajit 
Published: June 2022

AbstractThe chapter provides an overview of the volume by situating the Korean culture wave in South Asia. It elaborates the conceptual underpinning of transcultural flow in the age of globalization. Authors pointed out the lack of empirical research to understand the fandom, subculture and transcultural communication in the disciplinary domain of media, culture and communication in South Asia. Moving beyond the typical cultural studies approach to study media, youth and cultural texts, this chapter invites interdisciplinary approaches to capture the contemporary media practices. The chapter also outlines the chapters and thematic purview of the book.
Improved proof-by-contraction method and relative homologous entropy inequalities
Authors: Li Nan , Dong Chuan-Shi , Du Dong-Hui , Shu Fu-Wen 
Published: June 2022

Abstract
The celebrated holographic entanglement entropy triggered investigations on the connections between quantum information theory and quantum gravity. An important achievement is that we have gained more insights into the quantum states. It allows us to diagnose whether a given quantum state is a holographic state, a state whose bulk dual admits semiclassical geometrical description. The effective tool of this kind of diagnosis is holographic entropy cone (HEC), an entropy space bounded by holographic entropy inequalities allowed by the theory. To fix the HEC and to prove a given holographic entropy inequality, a proof-by-contraction technique has been developed. This method heavily depends on a contraction map f, which is very difficult to construct especially for more-region (n ≥ 4) cases. In this work, we develop a general and effective rule to rule out most of the cases such that f can be obtained in a relatively simple way. In addition, we extend the whole framework to relative homologous entropy, a generalization of holographic entanglement entropy that is suitable for characterizing the entanglement of mixed states.
Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice
Authors: Lopez-Tello Jorge , Schofield Zoe , Kiu Raymond , Dalby Matthew J. , van Sinderen Douwe , Le Gall Gwénaëlle , Sferruzzi-Perri Amanda N. , Hall Lindsay J. 
Published: June 2022

AbstractThe gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.
Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes
Authors: Wang Jiexun , Liu Jian-Jun , Gurung Resham L. , Liu Sylvia , Lee Janus , M Yiamunaa , Ang Keven , Shao Yi Ming , Tang Justin I-Shing , Benke Peter I. , Torta Federico , Wenk Markus R. , Tavintharan Subramaniam , Tang Wern Ee , Sum Chee Fang , Lim Su Chi 
Published: June 2022

Abstract
Aims/hypothesis
We sought to subtype South East Asian patients with type 2 diabetes by de novo cluster analysis on clinical variables, and to determine whether the novel subgroups carry distinct genetic and lipidomic features as well as differential cardio-renal risks.

Methods
Analysis by k-means algorithm was performed in 687 participants with recent-onset diabetes in Singapore. Genetic risk for beta cell dysfunction was assessed by polygenic risk score. We used a discovery–validation approach for the lipidomics study. Risks for cardio-renal complications were studied by survival analysis.

Results
Cluster analysis identified three novel diabetic subgroups, i.e. mild obesity-related diabetes (MOD, 45%), mild age-related diabetes with insulin insufficiency (MARD-II, 36%) and severe insulin-resistant diabetes with relative insulin insufficiency (SIRD-RII, 19%). Compared with the MOD subgroup, MARD-II had a higher polygenic risk score for beta cell dysfunction. The SIRD-RII subgroup had higher levels of sphingolipids (ceramides and sphingomyelins) and glycerophospholipids (phosphatidylethanolamine and phosphatidylcholine), whereas the MARD-II subgroup had lower levels of sphingolipids and glycerophospholipids but higher levels of lysophosphatidylcholines. Over a median of 7.3 years follow-up, the SIRD-RII subgroup had the highest risks for incident heart failure and progressive kidney disease, while the MARD-II subgroup had moderately elevated risk for kidney disease progression.

Conclusions/interpretation
Cluster analysis on clinical variables identified novel subgroups with distinct genetic, lipidomic signatures and varying cardio-renal risks in South East Asian participants with type 2 diabetes. Our study suggests that this easily actionable approach may be adapted in other ethnic populations to stratify the heterogeneous type 2 diabetes population for precision medicine.

Graphical abstract
Maximizing team synergy in AI-related interdisciplinary groups: an interdisciplinary-by-design iterative methodology
Authors: Bisconti Piercosma , Orsitto Davide , Fedorczyk Federica , Brau Fabio , Capasso Marianna , De Marinis Lorenzo , Eken Hüseyin , Merenda Federica , Forti Mirko , Pacini Marco , Schettini Claudia 
Published: June 2022

AbstractIn this paper, we propose a methodology to maximize the benefits of interdisciplinary cooperation in AI research groups. Firstly, we build the case for the importance of interdisciplinarity in research groups as the best means to tackle the social implications brought about by AI systems, against the backdrop of the EU Commission proposal for an Artificial Intelligence Act. As we are an interdisciplinary group, we address the multi-faceted implications of the mass-scale diffusion of AI-driven technologies. The result of our exercise lead us to postulate the necessity of a behavioural theory that standardizes the interaction process of interdisciplinary groups. In light of this, we conduct a review of the existing approaches to interdisciplinary research on AI appliances, leading to the development of methodologies like ethics-by-design and value-sensitive design, evaluating their strengths and weaknesses. We then put forth an iterative process theory hinging on a narrative approach consisting of four phases: (i) definition of the hypothesis space, (ii) building-up of a common lexicon, (iii) scenario-building, (iv) interdisciplinary self-assessment. Finally, we identify the most relevant fields of application for such a methodology and discuss possible case studies.
Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels
Authors: Zünkler Bernd J. , Wos-Maganga Maria , Bohnet Stefanie , Kleinau Anne , Manns Detlef , Chatterjee Shivani 
Published: June 2022

AbstractMost blockers of both hERG (human ether-à-go-go-related gene) channels and pancreatic ß-cell ATP-sensitive K+ (KATP) channels access their binding sites from the cytoplasmic side of the plasma membrane. It is unknown whether binding to intracellular components competes with binding of these substances to K+ channels. The whole-cell configuration of the patch-clamp technique, a laser-scanning confocal microscope, and fluorescence correlation spectroscopy (FCS) were used to study hERG channels expressed in HEK (human embryonic kidney) 293 cells and KATP channels from the clonal insulinoma cell line RINm5F. When applied via the pipette solution in the whole-cell configuration, terfenadine blocked both hERG and KATP currents with much lower potency than after application via the bath solution, which was not due to P-glycoprotein-mediated efflux of terfenadine. Such a difference was not observed with dofetilide and tolbutamide. 37–68% of hERG/EGFP (enhanced green-fluorescent protein) fusion proteins expressed in HEK 293 cells were slowly diffusible as determined by laser-scanning microscopy in the whole-cell configuration and by FCS in intact cells. Bath application of a green-fluorescent sulphonylurea derivative (Bodipy-glibenclamide) induced a diffuse fluorescence in the cytosol of RINm5F cells under whole-cell patch-clamp conditions. These observations demonstrate the presence of intracellular binding sites for hERG and KATP channel blockers not dialyzable by the patch-pipette solution. Intracellular binding of terfenadine was not influenced by a mutated hERG (Y652A) channel. In conclusion, substances with high lipophilicity are not freely diffusible inside the cell but steep concentration gradients might exist within the cell and in the sub-membrane space.
Graphical Abstract
On the infinitesimal generator of an optimal state semigroup
Authors: Acquistapace Paolo , Bucci Francesca 
Published: June 2022

AbstractIn this article we fully describe the domain of the infinitesimal generator of the optimal state semigroup which arises in the theory of the linear-quadratic problem for a specific class of boundary control systems. This represents an improvement over earlier work of the authors, joint with I. Lasiecka, where a set inclusion was established, but not an equality. The novel part of the proof of this result develops through appropriate asymptotic estimates that take advantage of the regularity analysis carried out in the study of the optimization problem, while the powers of positive operators and interpolation are still key tools. We also attest to the validity of an assumed relation between two significant parameters in the case of distinct systems of coupled hyperbolic–parabolic partial differential equations which are pertinent to the underlying framework.