bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase-locked photon-electron interaction without a laser
Authors: Taleb Masoud , Hentschel Mario , Rossnagel Kai , Giessen Harald , Talebi Nahid 
Published: October 2022

Abstract
Ultrafast electron-photon spectroscopy in electron microscopes commonly requires ultrafast laser setups. Photoemission from an engineered electron source is used to generate pulsed electrons, interacting with a sample that is excited by the ultrafast laser pulse at a specified time delay. Thus, developing an ultrafast electron microscope demands the exploitation of extrinsic laser excitations and complex synchronization schemes.
Here, we present an inverse approach based on cathodoluminescence spectroscopy to introduce internal radiation sources in an electron microscope. Our method is based on a sequential interaction of the electron beam with an electron-driven photon source (EDPHS) and the investigated sample. An electron-driven photon source in an electron microscope generates phase-locked photons that are mutually coherent with the near-field distribution of the swift electron. Due to their different velocities, one can readily change the delay between the photons and electrons arriving at the sample by changing the distance between the EDPHS and the sample. We demonstrate the mutual coherence between the radiations from the EDPHS and the sample by performing interferometry with a combined system of an EDPHS and a WSe2 flake. We assert the mutual frequency and momentum-dependent correlation of the EDPHS and sample radiation, and determine experimentally the degree of mutual coherence of up to 27%. This level of mutual coherence allows us to perform spectral interferometry with an electron microscope.
Our method has the advantage of being simple, compact and operating with continuous electron beams. It will open the door to local electron-photon correlation spectroscopy of quantum materials, single photon systems, and coherent exciton-polaritonic samples with nanometric resolution.
Specific miRNAs associated with treatment response during hospitalization for suicidal ideation
Authors: Kosten Thomas , Ye An , Nielsen David , Patriquin Michelle , Palat Asha , Rezaei Hengameh , Salas Ramiro , Harding Mark , Haile Colin , Gunaratne Preethi , Swann Alan 
Published: October 2022

Abstract
Brain epigenetic microRNAs (miRNA) can provide integrated and rapid brain regulation during recovery from suicidal ideation (SI), and because brain miRNA enter the circulation, plasma miRNA may be markers for SI recovery. Therefore, we used genome-wide miRNA expression profiling to measure plasma miRNA changes during resolution of SI and assessed mRNA-targets using functional annotation analyses. We correlated plasma miRNA with Columbia-Suicide Severity Rating Scores (C-SSRS), depression and anxiety in 42 SI and 26 non-SI inpatients at admission and 4–6 weeks later in recovery (C-SSRS = 0). The 42 SI patients showed down-regulation of four miRNAs (hsa-miR-424-5p, hsa-miR-378i, hsa-miR-6724-5p, and hsa-miR-10b-5p) after recovery from SI, while these four miRNAs showed no change for non-SI patients. We validated these differentially expressed (DE) miRNAs by qRT-PCR, and luciferase assays confirmed miRNA functional activity in Clusterin for miR-424-5p and in SDC1 for miR-10b-5p. Depression and anxiety improved and correlated with changes in miR-6724-5p and miR-378i, respectively. The serum protein Clusterin also increased in the plasma of the 42 recovered patients. mRNA target prediction for miR-378i, miR-10b-5p, and miR-424-5p yielded 37 hub genes. KEGG analyses showed enrichment in 5 to 15 hub genes within six neuronal pathways previously identified as critical in depression and suicidality: MAPK, ErbB, AMPK, Ras, p53, and PI3K-Akt. Thus, these four plasma miRNA changes and the associated modulation of six depression and suicidality pathways in brain may reflect brain-related epigenetic changes specifically involved in recovery from SI rather than reflecting non-specific changes in miRNA also found among non-SI inpatients.
Effect of cadmium in the gonads of mussel (Mytilus coruscus): A ionomics and proteomics study
Authors: Meng Chunying , Wang Kuiwu , Zhang Xiaojun , Zhu Xinyue 
Published: October 2022

Abstract
The mussel Mytilus coruscus is an important and very popular seafood in China and widespread along the eastern coast of China. In this study, we investigated the molecular response of mussel gonads to cadmium hyperaccumulation at two concentrations (80 and 200 µg/L) for 30 days using ionomics and proteomics techniques. The shrinkage of the cells and moderate hemocytic infiltration were observed in the Cd-treated groups. The strontium, selenium (Se), and zinc contents were significantly altered, and the relationships between iron, copper, Se, manganese, calcium, sodium, and magnesium were also significantly altered. Label-free quantitative proteomics analysis revealed a total of 227 differentially expressed proteins. These proteins were associated with multiple biological processes, including the tricarboxylic acid cycle, structural reorganization of cells, biosynthesis of amino acids, inflammatory response of cells and tumorigenesis. Nonetheless, our ionomics and proteomics analysis revealed that mussels could partly alleviate the adverse effects of Cd by altering the metal contents and correlations between minerals, thereby enhancing the biosynthesis of some amino acids and activity of antioxidant enzymes. Overall, this study provides insight into the mechanism underlying Cd toxicity in mussel gonads from a metal and protein perspective.
Effect of estrogen supplementation in the first trimester on pregnancy outcome of pregnant women with low serum estrogen level
Authors: Yang Zhengyi , Zheng Jie , Liu Jie , Lei Yalan , Sun Hong , Wen Xiaofeng , Xia Ming , Wang Xinxin , Ye Zhaoyang , Li Ling , Zhu Yanyan , Jing Zhichun 
Published: October 2022

AbstractBackground: Endocrine factors are one of the main causes of miscarriage, and estrogen and progesterone are hormones necessary for pregnancy and act in multiple settings of pregnancy, while clinical attention to estrogen levels is insufficient. This study was conducted to investigate the effect of estrogen supplementation on pregnancy outcomes in patients with low estrogen levels in early pregnancy .Methods: 279 pregnant women whose estrogen was below the optimal cut-off value for the diagnosis of adverse outcome corresponding to 4-6 weeks weeks were screened among those who underwent pregnancy monitoring at Hubei Provincial Maternal and Child Health Hospital from January 2021 to January 2022, and randomly divided into experimental group (149 cases) and control group (130 cases), and the experimental group was given progesterone + estrogen preparation + proprietary Chinese medicine to preserve fetus. The control group was given progesterone + proprietary Chinese medicine for fetal preservation.Results: In the study of estrogen supplementation on pregnancy outcome, the experimental group had a higher The success rate of fetal preservation was higher than that of the control group and was statistically significant (P<0.05).Conclusion: Dynamic monitoring of blood E2 values in early pregnancy ，before the placenta is fully formed, combined with a comprehensive analysis of their weekly optimal cut-off values, is important for clinical diagnosis and clinical intervention. Estrogen supplementation in pregnant women with low hormone levels may be beneficial to embryonic development and has implications for improving pregnancy outcomes. Estrogen acts in several aspects of pregnancy, and more in-depth studies on estrogen are necessary.
Organic/Inorganic phosphorus forms and transformation in long-term paddy cultivation in the Pearl River Delta, China
Authors: Tang Xian , Liu Hongyi , Jia Chongjian , Qin Hailong , zhao jianrong , wang hong , Lu Ying , li bo 
Published: October 2022

Abstract
Soil P availability in subtropical regions is often limited due to depletion as well as immobilization by abundant Fe minerals. Identification and quantification of different soil phosphorus (P) fractions is important for improving agricultural productivity and developing sustainable management practices in these agricultural soils under long-term cultivation due to limited P efficiency. However, few studies have been conducted to investigate P composition and transformation in these soils. This study was conducted to characterize P fractions as affected by different paddy cultivation ages (200, 400 and 900 years) among soils of the Pearl River Delta Plain in China. A sequential chemical fractionation scheme was employed as well as enzyme assay and 31P nuclear magnetic resonance spectroscopy (31P NMR) to quantify various P fractions and species. Results showed Total P (TP) and available P (AP) increased with cultivation age, ranging from 0.60–2.12 g kg− 1 and 3.67-224.17 mg kg− 1, respectively. Easily-labile, moderately-labile and non-labile P had similar relationship in topsoils (Ap1, Ap2 horizon) with TP and AP, and inversed relationships in the subsoil (Br3, G horizons). Analysis with 31P NMR spectroscopy revealed that inorganic P including orthophosphate (Ortho-P) and pyrophosphate (Pyro-P) increased with cultivation age, while organic species monoester phosphate (Mono-P) and diester phosphate (Diester-P) decreased. Moreover, acid phosphatase (AcP) and neutral phosphatase (NeP) activities increased with cultivation age and positively correlated with P fractions (p < 0.05). NeP, AcP, exchangeable Ca and sand content are the main factors of affecting soil P composition, however, non-labile P (Dil.HCl-Pi) and Pyro-P made a significant contribution to P availability. Therefore, long-term paddy cultivation, influenced by these soil parameters including NeP, AcP, exchangeable Ca and sand, accelerated the transformation of soil organic to inorganic P.
Image recognition of mine water inrush based on bilinear convolutional neural network with few-shot learning
Authors: Zhang Shuai , Qiang Wu , Xu hua , zhao yingwang , Du yuanze 
Published: October 2022

AbstractWith the increasingly widespread application of deep-learning technology in the field of coal mines, the image recognition of mine water inrush has become a hot research topic. Underground environments are complex, and images have high noise and low brightness. Additionally mine water inrush is accidental, and few actual image samples are available. Therefore, this paper proposes an algorithm that recognizes mine water inrush images based on few-shot deep learning. According to the characteristics of images with coal wall water seepage, A bilinear neural network was used to extract the image features and enhance the network's fine-grained image recognition. First, features was extracted using a bilinear convolutional neural network. Second, the network was pre-trained based on cosine similarity. Finally, the network was fine-tuned on the predicted image. For single-line feature extraction, the method is compared with big data and few-shot learning. According to the experimental results, the recognition rate reaches 95.2% for few-shot learning based on bilinear neural network, thus demonstrating its effectiveness.
Assessment of effect and feasibility of Sphagnum planting on soil carbon sink in paddy field
Authors: Ding Haifeng , Mu Yanyan , Wu Qimei , Wang Zhihui , Zhang Zhaohui 
Published: October 2022

Abstract
Aims
Slowing or reducing the increase of carbon dioxide in the atmosphere has become an international focus. Agricultural emissions, one of the most important sources of atmospheric carbon, are also a concern. How to increase agricultural carbon capture without hindering the development of agriculture has become an urgent matter.
Methods
This study was carried out in a mountainous area of southwest China. The carbon sinks of paddy fields were calculated by the sample plot inventory method, and the feasibility of replanting paddy fields in the study area and similar areas with Sphagnum was discussed from various aspects based on the actual local conditions.
Results
The results showed that the total soil organic carbon of 0-10cm in this study area was 15739.58t, about 35.18t/hm2. The soil organic carbon of 0-10cm in paddy field was about 12.34 t/hm2, and the carbon content of peat was more than three times that of paddy soil. Without the planting cost, the output value of Sphagnum planting in the study area can reach 9–10 times of that of rice. Moreover, Sphagnum planting in the study area had low requirements on soil nutrients and requires almost no manual management, the planting cost was much lower than that of rice planting.
Conclusion
In this study area, Sphagnum cultivation can take into account both economic and ecological benefits, which is an ideal agricultural model at present. However, due to its great environmental limitations, further research is needed to promote it.
IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation
Authors: Chang Li , Lee Chiang-Wen , Yang Chen-Yu , Lin Zih-Chan , Peng Kuo-Ti , Liu Shih-Chia , Wang Shih-Wei , Tsai Hsiao-Chi , Fong Yi-Chin , Lai Chao-Yang , Huang Yuan-Li , Tsai Chun-Hao , Ko Chih-Yuan , Liu Ju-Fang , Tang Chih-Hsin 
Published: October 2022

Abstract
New therapeutic approaches are needed for metastatic osteosarcoma (OS), as survival rates remain low despite surgery and chemotherapy. Epigenetic changes, such as histone H3 methylation, play key roles in many cancers including OS, although the underlying mechanisms are not clear. In this study, human OS tissue and OS cell lines displayed lower levels of histone H3 lysine trimethylation compared with normal bone tissue and osteoblast cells. Treating OS cells with the histone lysine demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX-1) dose-dependently increased histone H3 methylation and inhibited cellular migratory and invasive capabilities, suppressed matrix metalloproteinase expression, reversed epithelial-to-mesenchymal transition by increasing levels of epithelial markers E-cadherin and ZO-1 and decreasing the expression of mesenchymal markers N-cadherin, vimentin, and TWIST, and also reduced stemness properties. An analysis of cultivated MG63 cisplatin-resistant (MG63-CR) cells revealed lower histone H3 lysine trimethylation levels compared with levels in MG63 cells. Exposing MG63-CR cells to IOX-1 increased histone H3 trimethylation and ATP-binding cassette transporter expression, potentially sensitizing MG63-CR cells to cisplatin. In conclusion, our study suggests that histone H3 lysine trimethylation is associated with metastatic OS and that IOX-1 or other epigenetic modulators present promising strategies to inhibit metastatic OS progression.
Assessment and characterisation of hydrometeorological droughts in the Upper Mzingwane sub-catchment of Zimbabwe using station data
Authors: Chisadza Bright , Gwate Onalenna , Ncube France , Mpofu Nkululeko 
Published: October 2022

Abstract
Analysis of frequency and severity of droughts is critical for assessing the availability of surface water in ecosystems and for water resource planning. This study investigated hydrometeorological drought in the Upper Mzingwane sub-catchment using the standardised precipitation index (SPI) and reconnaissance drought index (RDI). Precipitation, minimum and maximum temperature data from three stations in the sub-catchment were used to calculate RDI and SPI for the period 1990–2020. Two-tailed Mann-Kendall and Pettitt tests were conducted to identify trends and breaks in the RDI and SPI values. The results showed that the sub-catchment was mainly affected by mild (62%) and moderate (20%) droughts. Significant increasing trends were observed for the calculated 6- and 12-month SPI and RDI values (p < 0.05), indicating a decreasing trend in long-term hydrological droughts. No trend was observed for the 3- and 6-month SPI and RDI values (p > 0.05). The Pettit test did not detect any breaks in the RDI and SPI values. SPI and RDI showed strong correlation coefficients (0.93–0.99) over similar time periods. Thus, both indices behaved in the same manner across multiple time intervals (3, 6, 9 and 12 months), but RDI was more sensitive to climatic conditions because of potential evapotranspiration. Approximately 14–16 droughts of varying severity occurred in the sub-catchment from 1990–2020. Despite increasing precipitation pattern, the catchment was still vulnerable to drought and this could undermine the ability of the catchment to deliver requisite ecosystem services such as water provision. Thus, drought forecasting, and information dissemination will be crucial to help stakeholders better prepare for future droughts in the sub-catchment.
Water Quality Assessment for Organic Matter Load in Urban Rivers Considering Land Use Dynamics
Authors: Leithold Juliana , Fernandes Cristovao Vicente Scapulatempo , Azevedo Júlio César Rodrigues , Kaviski Eloy 
Published: October 2022

Abstract
There has been an increasing number of global model studies that relate water quality to the watershed land use. The strategy of considering a model that is comparable to the Soil Conservation Service Curve-Number method that employs land use maps to estimate the effects of land use on the water quality, has considerable potential for application. In this context, this paper presents the LUPC (Land Use Pollutant Contribution) Model that relates pollutant loads originated by several types of coverage and a weight function which determines the load decay through water basin. It makes an estimate of the watershed features that are produced by conducting an analysis of the river profile, which is shown here in terms of the labile and refractory organic matter (OM), differentiated by its percentage of aromaticity. The initial results which were obtained by applying the model in a river basin located in the south of Brazil, suggest that the model can estimate the load of OM at a point of interest in the river and has proved to be a valuable tool for enabling managers to make decisions about the use planning land use and its impacts for water resources planning and management.
Stenting the unprotected left main coronary artery without invasive imaging techniques
Authors: Rafla Samir , Zaki Amr , Loutfi Mohamed , Sadaka Mohamed , Shebl Moataz 
Published: October 2022

Abstract
Background
New imaging modalities such as IVUS had improved results of stenting of the unprotected left main coronary artery (UPLM). The results of stenting UPLM without these new modalities but with meticulous care need to be studied more.
Methods
We analyzed data from 120 patients with UPLMD of > 50% subjected to stenting. All were stented by drug-eluting stents and followed for six months.
Results
92 patients (77.3%) presented with ACS, of which 65 patients (54.6%) had no Previous Intervention, and 27 patients (22.7%) had a previous PCI. Left ventricular ejection fraction significantly correlates with complication, at 6 months follow up; all 16 patients with reported complications (100%) had baseline LVEF of < 40% (P-value = 0.023). Syntax score: 11 patients (55%) with a high score of more than 32 had adverse events, P = 0.004. Residual syntax shows a less significant correlation with a mean value of 7.3 in the complication group versus 4.9 in the other group (P = 0.016). Final kissing balloon inflation shows no statistically significant difference.
Conclusions
PCI in UPLM is a safe, feasible option with a high technical success rate and acceptable outcome at follow-up even without the utilization of IVUS
Study of Metal Ion Absorption Capacity of Palygorskite by Computer Simulation
Authors: Liu Chuan-Wen , Liu Min-Hsien , Wang To-Mai , Chen Cheng-Lung , Ting Tzu-Hao 
Published: October 2022

Abstract
Palygorskite is a magnesium-rich aluminosilicate clay mineral with a unique chain-layered structure. Owing to this structure, palygorskite has a large specific surface area and interesting physical properties. Many researchers have investigated the applications of palygorskite in various fields including heavy metal adsorption, petroleum and chemical industries, building materials, medicine, and agriculture. In this study, molecular dynamic simulations were used to explore the heavy metal adsorption ability of palygorskite. The results showed that polyacrylic acid (PAA) had heavy metal adsorption ability. In terms of the ability of the substrate to adsorb Pb2+, Ni2+, and Cr3+, palygorskite (attapulgite, ATP) was more effective than SiO2 or clay. Based on this study, the same phenomenon reported in the literature was confirmed, and it was demonstrated that molecular dynamics can properly simulate the filtration of heavy metal ions in water using novel materials. Moreover, H+ ions were found to play an important role in assisting PAA/ATP in capturing heavy metal ions. Using this method, we were able to observe the details of the heavy-ion adsorption.
Assessing optimal medical therapy adherence following acute coronary syndrome utilising telehealth cardiology pharmacist clinics
Authors: Livori Adam C. , Pol Derk , Levkovich Bianca , Oqueli Ernesto 
Published: October 2022

Abstract
Background:

Optimal medical therapy (OMT) following acute coronary syndromes (ACS) and percutaneous coronary intervention (PCI) is a predictor of future major adverse cardiovascular events (MACE). Underutilisation of OMT is associated with higher risk of MACE within Australian populations.

Aims:

Effects of a telehealth cardiology pharmacist clinic (TCPC) on patient adherence to OMT and MACE in patients who received PCI for ACS.

Methods:

Retrospective matched cohort study within a large regional health service comparing patient populations before and after implementation of post-PCI TCPC with twelve-month follow up. Patients who received PCI for ACS were consulted by the pharmacist at one, three- and twelve-months’. Matching criteria included age, sex, presence of left ventricular dysfunction and ACS type. Primary outcome was difference in adherence to OMT at twelve months post PCI. Secondary outcomes included 4-point MACE at twelve months and validation of self-reported adherence using medication possession ratios from pharmacy dispensing records.

Results:

There were 156 patients in this study (78 matched pairs). Analysis of adherence to OMT at twelve months demonstrated an absolute increase in adherence to OMT by 13% (31 vs. 44%, p = 0.038). Furthermore, sub-optimal medication therapy (less than ACS medication groups at twelve months) reduced by 23% (31–8%, p = 0.004). MACE at twelve months reduced by 23% (31 vs.8% p = 0.004).

Conclusions:

This novel intervention significantly improved adherence at to OMT at twelve months; a demonstrated contributor to clinical outcomes. Primary and secondary outcomes in the intervention group were both statistically significant. Pharmacist-led follow up is both cost effective and improves patient outcomes.