bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling Performance of Microservices Systems with Growth Theory
Authors: Camilli Matteo , Russo Barbara 
Published: January 2022

AbstractContextThe microservices architectural style is gaining momentum in the IT industry. This style does not guarantee that a target system can continuously meet acceptable performance levels. The ability to study the violations of performance requirements and eventually predict them would help practitioners to tune techniques like dynamic load balancing or horizontal scaling to achieve the resilience property.ObjectiveThe goal of this work is to study the violations of performance requirements of microservices through time series analysis and provide practical instruments that can detect resilient and non-resilient microservices and possibly predict their performance behavior.MethodWe introduce a new method based ongrowth theoryto model the occurrences of violations of performance requirements as a stochastic process. We applied our method to an in-vitro e-commerce benchmark and an in-production real-world telecommunication system. We interpreted the resulting growth models to characterize the microservices in terms of their transient performance behavior.ResultsOur empirical evaluation shows that, in most of the cases, the non-linear S-shaped growth models capture the occurrences of performance violations of resilient microservices with high accuracy. The bounded nature associated with this models tell that the performance degradation is limited and thus the microservice is able to come back to an acceptable performance level even under changes in the nominal number of concurrent users. We also detect cases where linear models represent a better description. These microservices are not resilient and exhibit constant growth and unbounded performance violations over time. The application of our methodology to a real in-production system identified additional resilience profiles that were not observed in the in-vitro experiments. These profiles show the ability of services to react differently to the same solicitation. We found that when a service is resilient it can either decrease the rate of the violations occurrences in a continuous manner or with repeated attempts (periodical or not).ConclusionsWe showed that growth theory can be successfully applied to study the occurences of performance violations of in-vitro and in-production real-world systems. Furthermore, the cost of our model calibration heuristics, based on the mathematical expression of the selected non-linear growth models, is limited. We discussed how the resulting models can shed some light on the trend of performance violations and help engineers to spot problematic microservice operations that exhibit performance issues. Thus, meaningful insights from the application of growth theory have been derived to characterize the behavior of (non) resilient microservices operations.
“You Feel Like You Kind of Walk Between the Two Worlds”: A Participatory Study Exploring How Technology Can Support Emotion Regulation for Autistic People
Authors: Gillies-Walker Lauren , Ramzan Naeem , Rankin Jean , Nimbley Emy , Gillespie-Smith Karri 
Published: January 2022

AbstractAn increasing amount of technological solutions aiming to support emotion regulation are being developed for Autistic people. However, there remains a lack of understanding of user needs, and design factors which has led to poor usability and varied success. Furthermore, studies assessing the feasibility of emotion regulation technology via physiological signals for autistic people are increasingly showing promise, yet to date there has been no exploration of views from the autistic community on the benefits/challenges such technology may present in practice. Focus groups with autistic people and their allies were conducted to gain insight into experiences and expectations of technological supports aimed at supporting emotion regulation. Reflexive thematic analysis generated three themes: (1) communication challenges (2) views on emotion regulation technology (3) ‘how’ technology is implemented. Results provide meaningful insight into the socio-emotional communication challenges faced by autistic people, and explore the expectations of technology aimed at supporting emotion regulation.
The expression of pregnancy-associated plasma protein-A (PAPP-A) in human blastocoel fluid–conditioned media: a proof of concept study
Authors: Kavoussi Shahryar K. , Chen Shu-Hung , Wininger John David , Lal Arnav , Roudebush William E. , Lanford Hayes C. , Esqueda Amy S. , Barsky Maya , Lebovic Dan I. , Kavoussi Parviz K. , Gilkey Melissa S. , Chen Justin , Machen Graham L. , Chosed Renee J. 
Published: January 2022

Abstract
Purpose
The aim of this study was to determine if pregnancy-associated plasma protein-A (PAPP-A), typically measured in maternal serum and a potential predictor of adverse maternal and fetal outcomes such as spontaneous miscarriage, pre-eclampsia, and stillbirth, is expressed in blastocoel fluid–conditioned media (BFCM) at the embryonic blastocyst stage.

Design
This is an in vitro study.

Methods
BFCM samples from trophectoderm-tested euploid blastocysts (n = 80) from in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients were analyzed for PAPP-A mRNA. BFCM was obtained from blastocyst stage embryos in 20 uL drops. Blastocysts underwent trophectoderm biopsy for preimplantation genetic testing for aneuploidy prior to blastocyst vitrification and BFCM collection for snap freezing. cfDNA was synthesized using BFCM collected from 80 individual euploid blastocysts. Next, real-time qPCR was performed to detect expression of PAPP-A with GAPDH for normalization of expression in each sample.

Results
PAPP-A mRNA was detected in 45 of 80 BFCM samples (56.3%), with varying levels of expression across samples.

Conclusion
Our study demonstrates the expression of PAPP-A in BFCM. To our knowledge, this is the first study to report detection of PAPP-A mRNA in BFCM. Further studies are required and underway to investigate a greater number of BFCM samples as well as the possible correlation of PAPP-A expression with pregnancy outcomes of transferred euploid blastocysts. If found to predict IVF and obstetric outcomes, PAPP-A may provide additional information along with embryonic euploidy for the selection of the optimal blastocyst for embryo transfer.
Suppression of FPR2 expression inhibits inflammation in preeclampsia by improving the biological functions of trophoblast via NF-κB pathway
Authors: Li Shuxian , Li Anna , Zhai Liping , Sun Yaqiong , Yu Ling , Fang Zhenya , Zhang Lin , Peng Yanjie , Zhang Meihua , Wang Xietong 
Published: January 2022

Abstract
Purpose
The dysfunction of trophoblast during inflammation plays an important role in PE. Formyl peptide receptor 2 (FPR2) plays crucial roles in the development of inflammation-associated disease. This present study aimed to explore the effect of FPR2 on a trophoblast cellular model of preeclampsia.

Methods
The expression of FPR2 in placenta was detected by immunohistochemical staining and western blotting. Transfection of siRNA was used to knockdown FPR2 in HTR-8/SVneo cells. Inflammatory cytokines were detected by ELISA. CCK8, Transwell, wound healing, FACS and tube formation assays were performed to observe the abilities of cell proliferation, migration, invasion, apoptosis and angiogenesis. Western blotting was implemented to clarify that NF-κB signaling pathway was downstream of FPR2.

Results
The expression levels of FPR2 were higher in placental tissues of patients with PE. Knockdown of FPR2 expression by siFPR2 or inhibition of its activity by WRW4 decreased the release of proinflammatory cytokines in HTR8/SVneo cells treated with LPS. Knockdown of FPR2 expression or inhibition of its activity further reversed the LPS-induced attenuation of the proliferation, migration, invasion and angiogenesis and increase in apoptosis in HTR8/SVneo cells. Moreover, the NF-κB signaling pathway was activated in both placental tissues of patients with PE and LPS-treated HTR8/SVneo cells. However, the activation was attenuated when FPR2 was knocked down or inhibited.

Conclusion
Suppression of FPR2 expression alleviated the effects of inflammation induced by LPS on trophoblasts via the NF-κB signaling pathway, which provided a novel and potential strategy for the treatment of PE.
Nonlinear computational models of dynamical coding patterns in depression and normal rats: from electrophysiology to energy consumption
Authors: Li Yuanxi , Wang Rubin , Zhang Tao 
Published: January 2022

AbstractMajor depressive disorder (MDD) is one of the most serious neuropsychiatric disorders. Exploring the pathogenesis and dynamical coding patterns of MDD can provide new targets for clinical drug treatment and new ideas for the research of other neuropsychiatric and neurodegenerative diseases. We selected the medium spiny neuron (MSN) of nucleus accumbens (NAc) as the research objective. NAc is located in the dopaminergic pathway, regulating rewards, emotions and other behaviors. Abnormalities in these behaviors are considered as the main clinical symptoms of MDD. We simulated the different spike patterns of MSNs in MDD group and control group by dynamical Hodgkin–Huxley model. The simulated results can match the electrophysiological experiments, which occurred due to following reasons: (1) The external stimulus current of MDD group was amplified by the local neural microcircuit; (2) the selective permeability to sodium was abnormally decreased; and (3) the dopamine D2 receptor signaling pathway was abnormal in the MDD group. Furthermore, we proposed a dynamical energy model, and the energy results demonstrated that the energy cost in MDD group was lower, which led to persistent depression in patients with MDD. Simultaneously, the negative-to-total energy ratio of MSN in MDD group was higher than that in control group, and the delay time of the power peak and the potential peak in MDD group was shorter than that in the control group. The results showed that the abnormal firing patterns were the direct cause of abnormal behaviors of MDD and indicated that subthreshold activities of MDD group were more intense.
Innovation and borrower discouragement in SMEs
Authors: Brown Ross , Liñares-Zegarra José M. , Wilson John O.S. 
Published: January 2022

AbstractIn this paper, we investigate whether innovative small- and medium-sized enterprises (SMEs) are more likely to be discouraged from applying for external finance than non-innovators. These so-called discouraged borrowers are credit worthy SMEs who choose not to apply for external finance despite the fact that this is needed. We find that SMEs undertaking pure product and joint product and process innovation have a significantly higher incidence of borrower discouragement than non-innovative counterparts. Moreover, radical and incremental product innovators are more likely to be discouraged relative to non-innovative counterparts. Innovative activity can increase borrower discouragement for a myriad of reasons including fear of rejection, reluctance to take on additional risk, negative perceptions of the funding application process and perceived negative economic conditions. Overall, our results suggest a need for targeted policy interventions in order to alleviate borrower discouragement within innovative SMEs, as well as a closer alignment between innovation and SME finance policy.
My mother-in-law does not like it: resources, social norms, and entrepreneurial intentions of women in an emerging economy
Authors: Karim Shamsul , Kwong Caleb , Shrivastava Mili , Tamvada Jagannadha Pawan 
Published: January 2022

AbstractThis paper provides new evidence at the intersectionality of gender, family status, and culture by focusing on a previously little researched group of middle-class women in an emerging economy. While the existing literature examines both structural and normative constraints for women entrepreneurship, little is known about the gains from relaxing structural constraints for women when compared to men. In addition to examining this new question, the paper sheds light on the binding nature of normative constraints for women entrepreneurship that persist in a patriarchal developing economy even when structural constraints are significantly eased. Using a mixed-methods approach, the empirical results suggest that higher resource availability differentially impacts the entrepreneurial intentions of women when compared to men indicating the strong presence of normative barriers that inhibit their entrepreneurship. These normative barriers emerge through the roles people play within women life spheres inhibiting their entrepreneurial intentions.
Entrepreneurial organizing activities and nascent venture performance
Authors: Long Anna , Wood Matthew S. , Bennett Daniel L. 
Published: January 2022

AbstractThis research provides an improved understanding of how ventures successfully organize via resource allocations. Conceptually, we apply elements of action theory to account for resource trade-offs that occur as entrepreneurs make decisions about adding staff members to boundary spanning, technical core, and management functions. We then model how these allocation decisions differentially impact nascent venture performance. Empirically, we test our model with a sample of 2484 entrepreneurs captured in the Kauffman Firm Survey, a longitudinal dataset that tracks a random sample of US startups over an 8-year period. Results from dynamic panel estimation reveal evidence of both performance penalties and performance boosts as the result of entrepreneurs adding staff to specific areas, revealing optimality in specific configurations of entrepreneurial organizing elements.
A study of 25 years of publication outputs in the German academic profession
Authors: Schneijderberg Christian , Götze Nicolai , Müller Lars 
Published: January 2022

AbstractIn the weak evaluation state of Germany, full professors are involved in the traditional social governance partnership between the state, and the self-governing higher education institutions (HEI) and disciplinary associations. Literature suggests that formal and informal governance could trigger changes in academics’ publication behavior by valorizing certain publication outputs. In the article, secondary data from three surveys (1992, 2007 and 2018) is used for a multi-level study of the evolution of academics’ publication behavior. We find a trend toward the “model” of natural science publication behavior across all disciplines. On the organizational level, we observe that a strong HEI research performance orientation is positively correlated with journal articles, peer-reviewed publications, and co-publications with international co-authors. HEI performance-based funding is only positively correlated with the share of peer-reviewed publications. At the level of individual disciplines, humanities and social sciences scholars adapt to the peer-reviewed journal publication paradigm of the natural sciences at the expense of book publications. Considering how the academic profession is organized around reputation and status, it seems plausible that the academic profession and its institutional oligarchy are key contexts for the slow but steady change of academics’ publication behavior. The trend of changing academics’ publication behavior is partly related to HEI valorization of performance and (to a lesser extent) to HEI performance based-funding schemes, which are set by the strong academic profession in the weak evaluation state of Germany.
Food Insecurity Measurement: Stakeholder Comparisons of the EU-SILC and HFSSM Indicators and Considerations Towards the Usefulness of a Headline Indicator
Authors: Beacom Emma , Furey Sinéad , Hollywood Lynsey , Humphreys Paul 
Published: January 2022

AbstractPrior to the February 2019 announcement that the Household Food Security Survey Module (HFSSM) will be used to estimate household food insecurity, there has not been a standardised measurement approach used in the United Kingdom (UK). Measurement has instead been somewhat inconsistent, and various indicators have been included in national and regional surveys. There remains a gap relating to the comparative usefulness of current and past food insecurity measures used in Northern Ireland (NI) (HFSSM; European Union-Survey of Income and Living Conditions (EU-SILC) food deprivation questions), and the potential usefulness of a headline indicator similar to that used to measure fuel poverty. This study presents findings from Northern Ireland (NI) stakeholder interviews (n = 19), which examined their perspectives on food insecurity measures which have previously been or are currently, or could potentially, be used in the UK/NI (HFSSM; EU-SILC food deprivation questions; headline indicator). Interview transcripts were coded using QSR NVivo (v.12) and inductively analysed to identify relevant themes. Stakeholders preferred the HFSSM to the EU-SILC, reasoning that it is more relevant to the food insecurity experience. A headline indicator for food insecurity was considered useful by some; however, there was consensus that it would not fully encapsulate the food insecurity experience, particularly the social exclusion element, and that it would be a complex measure to construct, with a high degree of error. This research endorses the use of the HFSSM to measure food insecurity in the UK, and provides recommendations for consideration of any future modification of the HFSSM or EU-SILC measurement instruments.
Enactive Principles for the Ethics of User Interactions on Social Media: How to Overcome Systematic Misunderstandings Through Shared Meaning-Making
Authors: Marin Lavinia 
Published: January 2022

AbstractThis paper proposes three principles for the ethical design of online social environments aiming to minimise the unintended harms caused by users while interacting online, specifically by enhancing the users’ awareness of the moral load of their interactions. Such principles would need to account for the strong mediation of the digital environment and the particular nature of user interactions: disembodied, asynchronous, and ambiguous intent about the target audience. I argue that, by contrast to face to face interactions, additional factors make it more difficult for users to exercise moral sensitivity in an online environment. An ethics for social media user interactions is ultimately an ethics of human relations mediated by a particular environment; hence I look towards an enactive inspired ethics in formulating principles for human interactions online to enhance or at least do not hinder a user’s moral sensitivity. This enactive take on social media ethics supplements classical moral frameworks by asking us to focus on the relations established through the interactions and the environment created by those interactions.
The Effects of Group differentiation by students’ learning strategies
Authors: Haelermans Carla 
Published: January 2022

AbstractThis study analyses the effects of group differentiation by students’ learning strategies of around 1200 students in 46 classes from eight secondary schools in the Netherlands. In an experimental setup with randomization at the class level, division of students over three groups per class (an instruction-independent group, an average group, and an instruction-dependent group) is based on learning strategies, measures using the Motivated Strategies for Learning Questionnaire (MSLQ). Each group is offered instruction fitting their own learning strategy. The results show that student performance is higher in classes where the differentiation was applied, and that these students score higher at some scales of the posttest of the questionnaire on motivation, metacognition and self-regulation. However, there are differences between classrooms from different teachers. Additional teacher questionnaires confirm the discrepancy in teacher attitudes towards the intervention.
Evaluation of pesticide residues in commercial Swiss beeswax collected in 2019 using ultra-high performance liquid chromatographic analysis
Authors: Marti Joshua N. G. , Kilchenmann Verena , Kast Christina 
Published: January 2022

Abstract
The aim of this study was to determine residue levels of pesticides in Swiss commercial beeswax. Foundation samples were collected in 2019 from nine commercial manufacturers for analysis of 21 pesticides using ultra-high performance liquid chromatography. Individual samples showed the variability and residue ranges and pooled samples represented the average annual residue values of the Swiss production. In total, 17 pesticides were identified and 13 pesticides were quantified. They included 13 acaricides and/or insecticides, two fungicides as well as a synergist and a repellent. The means calculated from individual samples were similar to the average annual residue values for most tested pesticides. Mean values of 401, 236, 106 and 3 μg·kg−1 were obtained for the beekeeping-associated contaminants coumaphos, tau-fluvalinate, bromopropylate and N-(2,4-Dimethylphenyl)-formamide (DMF; breakdown product of amitraz), respectively. For the other pesticides, the mean values were 203 μg·kg−1 (synergist piperonyl butoxide), 120 μg·kg−1 (repellent N,N-Diethyl-3-methylbenzamide, DEET), 19 μg·kg−1 (chlorfenvinphos) and 4 μg·kg−1 ((E)-fenpyroximate), while the means for acrinathrin, azoxystrobin, bendiocarb, boscalid, chlorpyrifos, flumethrin, permethrin, propoxur and thiacloprid were below the limit of quantification (< LOQ). Individual samples contained from seven to 14 pesticides. The ranges of values for coumaphos and piperonyl butoxide (from 14 to 4270 μg·kg−1; from 6 to 1555 μg·kg−1, respectively) were larger as compared to the ranges of values for DEET and tau-fluvalinate (from < LOQ to 585 μg·kg−1; from 16 to 572 μg·kg−1, respectively). In conclusion, the most prominent contaminants were the pesticides coumaphos and tau-fluvalinate, which are both acaricides with previous authorization for beekeeping in Switzerland, followed by piperonyl butoxide, a synergist to enhance the effect of insecticides.
Graphical abstract