bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kemudahan Penggunaan dan Kemanfaatan Learning Management System (LMS) Terhadap Niat Penggunaan E-Learning
Authors: Listiyono Hersatoto , Sunardi Sunardi , Utomo Agus Prasetyo , Mariana Novita 
Published: September 2022

Tujuan dilakukannya penelitian ini adalah guna menganalisis dan menjelaskan pengaruh kemudahan dan kegunaan teknologi Learning Management System (LMS) terhadap niat mahasiswa dalam menggunakanya selama masa pandemi COVID 19. Variabel bebas adalah Kemudahan Penggunaan dan Kegunaan/kemanfaatan teknologi LMS, serta variabel terikatnya adalah Niat Pengguna LMS. Jenis penelitian penjelasan (explanatory research), yaitu melalui pengujian hipotesa dengan menjelaskan hubungan kausal antar variabel. Responden adalah mahasiswa Universitas Stikubank Semarang yang tersebar di 4 fakultas. Sampel sebanyak 93 responden dengan menggunakan teknik insedentil non propability sampling. Analisis data yang digunakan deskriptif kuantitatif dan analisis regresi linier berganda. Hasil uji hipotesis terdapat pengaruh positif dan signifikan variabel Kemudahan Penggunaan terhadap Niat Pengguna dengan nilai beta sebesar 0,207. Sementara itu variabel Kemanfaatan terhadap Niat Pengguna juga berpengaruh positif signifikan dengan nilai beta sebesar 0,664. Niat mahasiswa menggunakan LMS pada e-learning sebesar 68,8% (Adjusted R2) dipengaruhi variabel kemudahan dan kemanfaatan, sisanya sebesar 31,2% dipengaruhi oleh variabel lain. Selain itu, manfaat yang dirasakan memiliki pengaruh paling besar pada niat perilaku untuk menggunakan LMS.
The role of libraries as a social institution in the transforming Russian society
Authors: Kudrina E. L. , Bychkov L. D. , Zaruba N. A. 
Published: September 2022

The authors analyze the identified research and real-case publications on the critical problem: the libraries’ role as a social institution non-corresponding to the mission being conferred on them and its implementation. The purpose of the article is to actualize the problem related to the libraries’ role as a social institution and to attract attention of researchers in various domains, evoking interest to building professional competences in the specialists of social and cultural areas, including libraries. The authors suggest to develop management standards for the social institution of libraries to improve the quality of library services. The uniqueness of the study lies in the general analytical and comparative methods applied to existing standards, laws and conceptual documents for the institutions of culture. The researchers use competitive and systems methodological approaches. The empirical data of revealed sources are obtained through the methods of comparative analysis and systems analysis. The originality of the article is that the role of libraries is specified as a social institution going through transformation and intensive digitalization. The key functions of many social institutions (educational, cultural, families, etc.) are deflecting; their missions and roles are changing and being lost. On one hand, this is due to the chaos and inconsistency of transformation processes, and on the other hand, due to weakening control system and strengthening management system in business and economical processes. Today, despite the national programs, the problems of social systems affect economics, finances, ecology, etc.The current socioeconomic situation of transformation and intensive digitalization in every sphere of the Russian society, calls for regulated functions of social systems and their components. The analysis findings demonstrate that the libraries as a social institution have been losing their mission, while random and chaotic transformation processes result in imbalance and do harm. The social institutions depreciate the libraries’ implementing social functions which is evidenced by the analysis of legal and regulatory and conceptual acts in the cultural and social sphere. One of the solutions is to strengthen management of the libraries as a social institution and improving expertise of librarians.
sistema político y la constitución - Tipos de democracia en el Ecuador
Authors: Lopez-Lopez Freddy Geovanny 
Published: September 2022

Analizar el sistema político constitucional permite identificar los tipos de democracia que fueron incorporados a la Constitución de la República del Ecuador. Muchas veces estos no son explícitamente señalados en los preceptos constitucionales, pero, se infieren de la interpretación restrictiva o expansiva de la norma.
El objeto del presente artículo es identificar en el texto constitucional las modalidades de manifestación de la democracia en el Ecuador, exteriorizada en las diversas funciones del Estado y analizar, si las expresiones de función pública amparan de manera efectiva los derechos y las garantías constitucionales.
La investigación sigue una metodología de enfoque cualitativo, de tipo documental por sus fuentes, descriptivo por su alcance y diseño no experimental, que arrojó como resultado que la democracia aplicable en Ecuador es de tipo representativa, delegativa, constitucional y procedimental que permite de manera efectiva la defensa y garantía de los derechos fundamentales establecidos en la Carta Magna.
Improving the thermostability of alginate lyase FlAlyA with high expression by computer-aided rational design for industrial preparation of alginate oligosaccharides
Authors: Zhang Xiu , Li Wei , Pan Lixia , Yang Liyan , Li Hongliang , Ji Feng , Zhang Yunkai , Tang Hongzhen , Yang Dengfeng 
Published: September 2022

FlAlyA, a PL7 alginate lyase with industrial potential, is widely applied in the preparation the alginate oligosaccharide because of its high activity of degradation the alginate. However, heat inactivation still limits the industrial application of FlAlyA. To further enhance its thermostability, a group of mutants were designed, according to evaluating the B-factor value and free energy change via computer-aided calculation. 25 single-point mutants and one double-points mutant were carried out by site-directed mutagenesis. The optimal two single-point mutants H176D and H71K showed 1.20 and 0.3°C increases in the values of Tm, while 7.58 and 1.73 min increases in the values of half-life (t1/2) at 50°C, respectively, compared with that of the wild-type enzyme. Interestingly, H71K exhibits the comprehensive improvement than WT, including expression level, thermal stability and specific activity. In addition, the mechanism of these two mutants is speculated by multiple sequence alignment, structural basis and molecular dynamics simulation, which is likely to be involved in the formation of new hydrogen bonds and decrease the SASA of the mutants. These results indicate that B-factor is an efficient approach to improves the thermostability of alginate lyase composed of β-sheet unit. Furthermore, the highest yield of the mutant reached about 650 mg/L, which was nearly 36 times that of previous studies. The high expression, excellent activity and good thermal stability make FlAlyA a potential candidate for the industrial production of alginate oligosaccharides.
Stability of internal fixation systems based on different subtypes of Schatzker II fracture of the tibial plateau: A finite element analysis
Authors: Zeng Chuyang , Ren Xiaomeng , Xu Cheng , Hu Mengmeng , Li Jiantao , Zhang Wei 
Published: September 2022

Background: Schaztker II fracture is the most common type of the tibial plateau fractures (TPF). There has been a large number of cadaveric biomechanical studies and finite element simulation studies to explore the most stable fixation methods for this type of fracture, which were based on a single fracture morphology. But differences among fracture morphologies could directly affect the stability of internal fixation systems. In this sense, we verified the stability of existing internal fixation modalities by simulating Schatzker II fractures with different fracture morphologies.Objectives: To compare the stability of different filler types combined with locked compression plate/screw in different subtypes of Schatzker II TPF.Methods: Four subtypes of Schatzker II were created based on 3D map of TPF. Each of the subtypes was fixed with LCP/screw or LCP/screw combined with different fill types. Stress distribution, displacement distribution, and the load sharing capacity of the filler were assessed by applying the maximum load during gait. In addition, repeated fracture risks of depressed fragment were evaluated regarding to the ultimate strain of bone.Results: The stress concentration of the implant in each scenario was located on the screw at the contact site between the plate and the screw, and the filler of the defect site significantly reduced the stress concentration of the implant (Subtype A: Blank group 402.0 MPa vs. Experimental group 315.2 ± 5.5 MPa; Subtype C: Blank group 385.0 MPa vs. Experimental group 322.7 ± 12.1 MPa). Displacement field analysis showed that filler significantly reduced the reduction loss of the depressed fragment (Subtype A: Blank group 0.1949 mm vs. Experimental group 0.174 ± 0.001 mm; Subtype C: 0.264 mm vs. 0.253 ± 0.002 mm). Maximum strain was in subtype C with the value of 2.3% ± 0.1% indicating the greatest possibility of failure risk. And with the increase of its modulus, the bearing capacity of filler increased.Conclusion: The existence of filler at the defect site can effectively reduce the stress concentration of the implant and the reduction loss of the collapsed block, thus providing good stability for Schatzker II fracture. In subtype A fracture, the modulus of filler presented the slightest influence on the stability, followed by subtype C, while the stability of subtype B was most influenced by the modulus of filler. Therefore, it is necessary to evaluate the preoperative patient imaging data adequately to select the appropriate stiffness of the filler.
Decellularized bovine jugular vein and hand-sewn ePTFE valved conduit for right ventricular outflow tract reconstruction in children undergoing Ross procedure
Authors: Yuan Haoyong , Lu Ting , Wu Zhongshi , Yang Yifeng , Chen Jinlan , Wu Qin , Wu Sijie , Zhang Hong , Qian Tao , Huang Can 
Published: September 2022

BackgroundThe Ross procedure is recommended as an optimal aortic valve replacement (AVR) in children and young adults due to several advantages. Nevertheless, multiple reconstructions of the right ventricular outflow tract (RVOT) with new valve conduits have caused some concern regarding the durability of the Ross AVR. Decellularized bovine jugular vein conduit (BJVC) (DP-BJVC) and hand-sewn expanded polytetrafluoroethylene valved conduits (ePTFE VC) are widely employed to reconstruct the RVOT with satisfactory long-term outcomes. However, few studies have compared the safety and efficacy between the two valve conduits. We aimed to evaluate the early outcomes and report our single center experience in the application of these conduits.MethodsTwenty-two pediatric patients (aged &lt; 18 years) who underwent Ross procedures with DP-BJVC and ePTFE VC in our center between 1 June, 2017 and 31 January, 2022 were enrolled. The Kaplan–Meier method was used to evaluate survival, freedom from RVOT reintervention, and freedom from RVOT graft dysfunction. Mixed-effects analysis with the Geisser–Greenhouse correction and Sidak's multiple comparisons test for post-hoc analysis was employed to compare the peak gradient across the conduit at varying follow-ups.ResultsAll patients were followed up in full. The total early survival rate was 90.9%; two patients in the DP-BJVC group died. There was no significant difference in early mortality, cross-clamp time (p = 0.212), in-hospital stay (p = 0.469), and RVOT graft thrombosis or endocarditis between the two groups. There was similarly no significant difference between Kaplan–Meier freedom from RVOT graft dysfunction curve (P = 0.131). The transprosthetic gradient gradually increased over time in both groups and was significantly higher in the DP-BJVC group at follow-up (P &lt; 0.05).ConclusionsBoth conduits show excellent early and midterm outcomes for RVOT reconstruction in the Ross procedure. We suggest that DP-BJVC is more suitable for infants, and ePTFE conduit is more suitable for older children who require larger conduits.
Digital competency of Psychologists in Aotearoa New Zealand: A cross-sectional survey
Authors: Dobson Rosie , Variava Rushaina , Douglas Meihana , Reynolds Lisa M. 
Published: September 2022

BackgroundThe increasing implementation of digital health into psychological practice is transforming mental health services. Limited clinical resources and the high demand for psychological services, alongside the restrictions imposed on services during the global COVID-19 pandemic, have been a catalyst for significant changes in the way psychologists work. Ensuring Psychologists have the skills and competence to use these tools in practice is essential to safe and ethical practice.AimThis study aimed to explore the digital competence of psychologists working in Aotearoa New Zealand and their use of digital tools in the practice.MethodsA cross-sectional online survey was conducted with Aotearoa New Zealand Registered Psychologists (n = 195) between July and November 2021.ResultsParticipants reported varying degrees of competence across the digital tasks presented, with participants most commonly reporting moderate to high competence for engaging in remote supervision via digital means (86%) and obtaining client's informed consent for digital work (82%). In contrast, tasks that participants most reported not being moderately or highly competent in included working with interpreters remotely and evaluating the effectiveness and security of smartphone apps. Motivations to use digital technologies included meeting client preferences and needs, necessity for continuity of care, and the benefits of increased accessibility and reach. In contrast, the barriers to using digital technologies included client characteristics or preference, clinical factors, clinician preferences and skills, and workplace or technical issues or concerns. The majority (91.1%) were potentially interested in further training in this area.ConclusionsThe current study offers insights into the digital competencies of a workforce that has required rapid incorporation of technologies into professional practice over recent years. This snapshot of the digital skills of psychologists demonstrates a large variation in digital competence. In the current context, developing digital competencies seems a fundamental requirement for psychologists to work in ways that appropriately and safely deliver client-centred care.
Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study
Authors: Bulka Catherine M. , Eaves Lauren A. , Gardner Amaree J. , Parsons Patrick J. , Galusha Aubrey L. , Roell Kyle R. , Smeester Lisa , O'Shea T. Michael , Fry Rebecca C. 
Published: September 2022

BackgroundPrenatal exposures to metallic and metalloid trace elements have been linked to altered immune function in animal studies, but few epidemiologic studies have investigated immunological effects in humans. We evaluated the risk of bacterial sepsis (an extreme immune response to bacterial infection) in relation to prenatal metal/metalloid exposures, individually and jointly, within a US-based cohort of infants born extremely preterm.MethodsWe analyzed data from 269 participants in the US-based ELGAN cohort, which enrolled infants delivered at &lt;28 weeks' gestation (2002–2004). Concentrations of 8 trace elements—including 4 non-essential and 4 essential—were measured using inductively coupled plasma tandem mass spectrometry in umbilical cord tissue, reflecting in utero fetal exposures. The infants were followed from birth to postnatal day 28 with bacterial blood culture results reported weekly to detect sepsis. Discrete-time hazard and quantile g-computation models were fit to estimate associations for individual trace elements and their mixtures with sepsis incidence.ResultsApproximately 30% of the extremely preterm infants developed sepsis during the follow-up period (median follow-up: 2 weeks). After adjustment for potential confounders, no trace element was individually associated with sepsis risk. However, there was some evidence of a non-monotonic relationship for cadmium, with hazard ratios (HRs) for the second, third, and fourth (highest) quartiles being 1.13 (95% CI: 0.51–2.54), 1.94 (95% CI: 0.87–4.32), and 1.88 (95% CI: 0.90–3.93), respectively. The HRs for a quartile increase in concentrations of all 8 elements, all 4 non-essential elements, and all 4 essential elements were 0.92 (95% CI: 0.68–1.25), 1.19 (95% CI: 0.92–1.55), and 0.77 (95% CI: 0.57–1.06). Cadmium had the greatest positive contribution whereas arsenic, copper, and selenium had the greatest negative contributions to the mixture associations.ConclusionsWe found some evidence that greater prenatal exposure to cadmium was associated with an increased the risk of bacterial sepsis in extremely preterm infants. However, this risk was counteracted by a combination of arsenic, copper, and selenium. Future studies are needed to confirm these findings and to evaluate the potential for nutritional interventions to prevent sepsis in high-risk infants.
GraphBio: A shiny web app to easily perform popular visualization analysis for omics data
Authors: Zhao Tianxin , Wang Zelin 
Published: September 2022

Background: Massive amounts of omics data are produced and usually require sophisticated visualization analysis. These analyses often require programming skills, which are difficult for experimental biologists. Thus, more user-friendly tools are urgently needed.Methods and Results: Herein, we present GraphBio, a shiny web app to easily perform visualization analysis for omics data. GraphBio provides 15 popular visualization analysis methods, including heatmap, volcano plots, MA plots, network plots, dot plots, chord plots, pie plots, four quadrant diagrams, Venn diagrams, cumulative distribution curves, principal component analysis (PCA), survival analysis, receiver operating characteristic (ROC) analysis, correlation analysis, and text cluster analysis. It enables experimental biologists without programming skills to easily perform popular visualization analysis and get publication-ready figures.Conclusion: GraphBio, as an online web application, is freely available at http://www.graphbio1.com/en/ (English version) and http://www.graphbio1.com/ (Chinese version). The source code of GraphBio is available at https://github.com/databio2022/GraphBio.
An application based on bioinformatics and machine learning for risk prediction of sepsis at first clinical presentation using transcriptomic data
Authors: Shi Songchang , Pan Xiaobin , Zhang Lihui , Wang Xincai , Zhuang Yingfeng , Lin Xingsheng , Shi Songjing , Zheng Jianzhang , Lin Wei 
Published: September 2022

Background: Linking genotypic changes to phenotypic traits based on machine learning methods has various challenges. In this study, we developed a workflow based on bioinformatics and machine learning methods using transcriptomic data for sepsis obtained at the first clinical presentation for predicting the risk of sepsis. By combining bioinformatics with machine learning methods, we have attempted to overcome current challenges in predicting disease risk using transcriptomic data.Methods: High-throughput sequencing transcriptomic data processing and gene annotation were performed using R software. Machine learning models were constructed, and model performance was evaluated by machine learning methods in Python. The models were visualized and interpreted using the Shapley Additive explanation (SHAP) method.Results: Based on the preset parameters and using recursive feature elimination implemented via machine learning, the top 10 optimal genes were screened for the establishment of the machine learning models. In a comparison of model performance, CatBoost was selected as the optimal model. We explored the significance of each gene in the model and the interaction between each gene through SHAP analysis.Conclusion: The combination of CatBoost and SHAP may serve as the best-performing machine learning model for predicting transcriptomic and sepsis risks. The workflow outlined may provide a new approach and direction in exploring the mechanisms associated with genes and sepsis risk.
COVID-19 and related social distancing measures induce significant metabolic complications without prominent weight gain in Korean adults
Authors: Ko Hae-Jin , Cho Yoon Jeong , Kim Kyoung-Kon , Kang Jee-Hyun , Kim Young-Sang , Haam Ji-Hee , Hur Yang-Im , Choi Hye-In , Lee Kyu Rae , Park Jung Ha , Cho Soo Hyun , Kim Jong-Koo , Lee Taesic , Seo Myung-Jae , Yoon Yeong Sook , Seo Yoobin , Nam Ga Eun , Kim Sun Hyun 
Published: September 2022

BackgroundThis study using multi-center health examination data from Korean adults was conducted to confirm changes in weight, and their related cardiometabolic parameters, before and after strengthening of social distancing regulations.MethodsA retrospective cohort study was conducted using health check-up data from 13 university hospitals. The study period was from January 2018 to July 2020. To examine the effect of systematic social distancing measures, participants who underwent a health check-up (Visit 3) between July 2020 and July 2021 (during full scale social distancing), and had undergone two previous health check-ups (Visits 1 and 2) between January 2018 and June 2020 (before social distancing), were selected. In total, data from 7,875 participants were analyzed. Linear mixed-effect models were used to calculate estimates of anthropometric indices and metabolic markers measured on Visits 2 and 3, compared with measurements from Visit 1.ResultsThere were no significant differences in body weight, body mass index, waist circumference, and body composition on Visit 3 than on Visits 1 and 2. However, the odds of metabolic syndrome and its components, including hypertension, high glucose, diabetes, hypercholesterolemia, hypertriglyceridemia, hyper-non-high-density lipoprotein cholesterolemia, and dyslipidemia were significantly higher on Visit 3 than on Visits 1 and 2. The increase in metabolic complications was marked, particularly in relatively young adults who visited health check-up centers located in the capital area.ConclusionMetabolic syndrome and its components were significantly worse after high level social distancing, although there were no significant increases in anthropometric indices and body fat levels. Healthcare providers need to prevent and manage worsening of metabolic parameters in subpopulations prone to be more sedentary and eat unhealthy food during the COVID-19 pandemic and associated social distancing measures.