bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation
Authors: Silachev Denis , Koval Alexey , Savitsky Mikhail , Padmasola Guru , Quairiaux Charles , Thorel Fabrizio , Katanaev Vladimir L. 
Published: January 2022

AbstractGNAO1 encephalopathy characterized by a wide spectrum of neurological deficiencies in pediatric patients originates from de novo heterozygous mutations in the gene encoding Gαo, the major neuronal G protein. Efficient treatments and even the proper understanding of the underlying etiology are currently lacking for this dominant disease. Adequate animal models of GNAO1 encephalopathy are urgently needed. Here we describe establishment and characterization of mouse models of the disease based on two point mutations in GNAO1 with different clinical manifestations. One of them is G203R leading to the early-onset epileptic seizures, motor dysfunction, developmental delay and intellectual disability. The other is C215Y producing much milder clinical outcomes, mostly-late-onset hyperkinetic movement disorder. The resultant mouse models show distinct phenotypes: severe neonatal lethality in GNAO1[G203R]/ + mice vs. normal vitality in GNAO1[C215Y]/ + . The latter model further revealed strong hyperactivity and hyperlocomotion in a panel of behavioral assays, without signs of epilepsy, recapitulating the patients’ manifestations. Importantly, despite these differences the two models similarly revealed prenatal brain developmental anomalies, such as enlarged lateral ventricles and decreased numbers of neuronal precursor cells in the cortex. Thus, our work unveils GNAO1 encephalopathy as to a large extent neurodevelopmental malady. We expect that this understanding and the tools we established will be instrumental for future therapeutic developments.
A national study on the resilience of community pharmacists in Lebanon: a cross-sectional survey
Authors: Alameddine Mohamad , Bou-Karroum Karen , Hijazi Mohamad Ali 
Published: January 2022

Abstract
Background
Community pharmacists are among the most accessible healthcare professionals and are likely to experience the full brunt of public health crises. In Lebanon, the COVID-19 pandemic, added to a severe economic meltdown, have significantly disrupted an already suffering profession.

Methods
The objective of this study was to determine the level of resilience and its relationship to burnout, job satisfaction, intention to quit, and changes in practice. The study utilized a cross-sectional design to survey community pharmacists using an online questionnaire that included the Connor-Davidson Resilience Scale and the Copenhagen Burnout Inventory. All community pharmacists were invited to participate. Multiple logistic regression identified variables significantly associated with the resilience of pharmacists.

Results
A total of 459 community pharmacists completed the questionnaire. Respondents had a relatively low resilience level (68.0 ± 13.37). They also had higher scores on the client-related burnout (58.06 ± 17.46), followed by the personal burnout (56.51 ± 16.68) and the work-related burnout (55.75 ± 13.82). In this sample, 52.3% of pharmacists indicated that they are dissatisfied with their job and 41.1% indicated an intention to quit in the coming year. According to multivariate analysis, marital status (ß = 0.38; 95% CI 0.16–0.91; p = 0.03), intention to quit (ß = 0.384; 95% CI 0.149–0.987; p = 0.047), workload (ß = 0.275; 95% CI 0.096–0.783; p = 0.016), perception of safety (ß = 0.267; 95% CI 0.078–0.909; p = 0.035), and personal burnout (ß = 0.321; 95% CI 0.152–0.677; p = 0.003) were independent influencing factors for resilience.

Conclusions
Multiple challenges and crises have culminated to the low job satisfaction, high burnout, and high the intention to quit of community pharmacists. This seriously destabilized the labor market of pharmacists which could negatively affect public safety. Effective interventions are essential to enhance the well-being and job satisfaction of pharmacists during public health crisis.
Modulatory efficacy of Punica granatum L. powder ethanol extract (PLEE) on lead acetate-induced hepatic and renal toxicity
Authors: Adebisi Oluwaseun Abraham , Agbaje Wasiu Bolade , Adewale Omowumi Oyeronke 
Published: January 2022

Abstract
Background
Pomegranate powder derived from pomegranate fruit contains phytochemicals chief of which is ellagitannins. Owing to their high antioxidative capabilities we investigated its efficacy against lead acetate induced hepatic and renal toxicity.

Methods
Pomegranate powder (500 g) was procured and soaked in 1 Litre of ethanol for three days, its filtrate was concentrated and freeze dried to form Punica granatum L. ethanol extract (PLEE). Thirty (30) male albino Wistar rats with average weight between 140 ± 20 g were used for this study. They were equally shared into 6 groups with 5 animals each; A: Control; B: Lead acetate only C: Lead acetate + PLEE (1); D: Lead acetate + PLEE (2); E: PLEE (1) and F: PLEE (2). Serum, liver and kidney samples were obtained for biochemical assays. The integrity of liver and kidney tissues were also accessed.

Results
Lead administration resulted in marked elevations in liver transaminases in serum and liver as well as a significant increase in kidney function markers in the serum and kidney (p < 0.05). There was also a significant decline in average body weight, antioxidant markers in the liver and kidney of Wistar rats while there was a significant increase in lipid peroxidation levels in both liver and kidney. However, administration of PLEE at different doses significantly modulated these changes.

Conclusion
Lead acetate administration led to hepatic and renal toxicity as evident by alterations in liver and kidney function markers, antioxidant status and tissue integrity. However, PLEE can combat these toxicities.
Does race impact speech perception? An account of accented speech in two different multilingual locales
Authors: Kutlu Ethan , Tiv Mehrgol , Wulff Stefanie , Titone Debra 
Published: January 2022

AbstractUpon hearing someone’s speech, a listener can access information such as the speaker’s age, gender identity, socioeconomic status, and their linguistic background. However, an open question is whether living in different locales modulates how listeners use these factors to assess speakers’ speech. Here, an audio-visual test was used to measure whether listeners’ accentedness judgments and intelligibility (i.e., speech perception) can be modulated depending on racial information in faces that they see. American, British, and Indian English were used as three different English varieties of speech. These speech samples were presented with either a white female face or a South Asian female face. Two experiments were completed in two locales: Gainesville, Florida (USA) and Montreal, Quebec (Canada). Overall, Montreal listeners were more accurate in their transcription of sentences (i.e., intelligibility) compared to Gainesville listeners. Moreover, Gainesville listeners’ ability to transcribe the same spoken sentences decreased for all varieties when listening to speech paired with South Asian faces. However, seeing a white or a South Asian face did not impact speech intelligibility for the same spoken sentences for Montreal listeners. Finally, listeners’ accentedness judgments increased for American English and Indian English when the visual information changed from a white face to a South Asian face in Gainesville, but not in Montreal. These findings suggest that visual cues for race impact speech perception to a greater degree in locales with greater ecological diversity.
The use of system dynamics for energy and environmental education
Authors: Strapasson Alexandre , Ferreira Marcello , Cruz-Cano Diego , Woods Jeremy , do Nascimento Maia Soares Marco Paulo , da Silva Filho Olavo Leopoldino 
Published: January 2022

AbstractThe use of system dynamics as a learning tool for developing sustainable energy strategies and environmental education has advanced in recent years with the availability of new modelling software and webtools. Among the existing models, we highlight the online 2050 Calculators, which aim at simulating scenarios for greenhouse gas emissions, energy planning, sustainable land use, and food consumption. The objective of this study is to assess the available calculators and their contribution to an interdisciplinary education via systems thinking. We carried out a review of the existing models worldwide and ran some of the tools with students from three different postgraduate programmes at master’s level at Imperial College London (United Kingdom) and IFP School (France), whilst also assessing their individual views afterwards. The assessments were conducted once a year during three subsequent years: 2019, 2020, and 2021. The results are discussed under the epistemology of critical pedagogy, showing that the use of webtools, such as the 2050 Calculators, can significantly contribute to the students’ environmental awareness and political engagement, providing important lessons about the use of system dynamics for policy and science education.
Clinico-bacteriological profile and antibiotic resistance pattern in patients with acute exacerbation of COPD
Authors: Mood Narayan , Katta Surendar Reddy , Badam Aruna Kumari , Chundru Jayaram 
Published: January 2022

Abstract
Background
Repeated attacks of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have been attributed to bacterial infections. However, sputum microbiology for identifying the bacteriological profile is not performed usually and remains controversial. Thus, we performed a prospective, cross-sectional study to assess the clinico-bacteriological profile of the patients with AECOPD and antibiotic resistance pattern of bacteria isolated from sputum samples. The study involved 104 consecutive hospitalized patients, of either gender, aged 40–90 years, and diagnosed with AECOPD. Before initiating an empirical antibiotic therapy, the sputum samples of all the patients were collected and subjected to Gram staining, bacterial culture, and antibiotic sensitivity.

Results
The most common bacterial isolates were P. aeruginosa (30.7%) followed by K. pneumoniae (20.3%) and S. pneumoniae (8.6%). Both Gram-positive and Gram-negative bacteria were most sensitive to Meropenem (91%) followed by Amoxicillin-clavulanic acid (83%). However, these bacteria were most resistant to Cefoperazone-sulbactam (43%) followed by Levofloxacin (41%). P. aeruginosa and K. pneumoniae were most resistant to Cefoperazone-sulbactam (23%) followed by Fluoroquinolones (23–35%), while S. pneumoniae was most resistant to Ciprofloxacin (44%) followed by Amoxicillin-clavulanic acid (33%).

Conclusions
Isolation of P. aeruginosa, as the most common agent, further confirms its roles in severe attacks of AECOPD. The regularly used antibiotics were found to be resistant to most isolates, thereby suggesting that severity of AECOPD may be attributed to the prevalence of antibiotic-resistant strains.
Tympanoplasty success based on surgeon and patient-reported outcomes perspectives: a 10-year review in a tertiary center
Authors: Tshifularo M. 
Published: January 2022

Abstract
Background
The latest international trends in healthcare put more emphasis on patients’ perspectives in reporting success in surgical procedures. A holistic approach in measuring surgical outcomes, defined as global success, should include the patient’s perioperative experiences, expectations, and outcome measures. In published literature, surgeons propose several definitions of post-operative successful surgical outcomes following tympanoplasty. Most surgical outcomes and the surgeon’s definition of success exclude the patient’s perspectives. Patient-reported outcomes would allow surgeons to understand and measure the benefit of the several procedures performed from the perspective of the patients. Current definitions of successful tympanoplasty do not capture patient reported outcomes which are important to patients. A divergence is frequently found between outcomes relevant to the patient and to the surgeon. Patient-reported outcomes would complement traditionally measured clinical outcomes by the surgeon to give a true global outcome measuring success. The main aim of the current study was to propose a definition of true global success following tympanoplasty by combining the patient’s and the surgeon’s reported satisfaction rate based on the indication and the goals for the operation.

Results
A total of 128 procedures were performed on128 ears in 125 patients, of which 52% (n = 57) were done on the right and 48% (n = 61) on the left side. There was no significant difference between the two groups (p = 0.07). There was a female preponderance, with 62% females and 44% males (p = 0.105). The majority of patients, 63% (n = 68), were between the age of 26 and 45 years, while 19% (n = 20) fell into the 46- to 60-year age range, with no significant difference between the groups (p = 0.21). There was complete graft take in 77% (107/128) of the ears in whereas 23% (21/128) of the ears the graft had not taken at the 6-month follow-up period. The true global success satisfaction rate was 92% (chi-square test = 119; p = 0.001) compared to the 77% surgical success.

Conclusion
In assessing success in tympanoplasty, the patient- and surgeon-reported outcomes, when considered against agreed goals and indications, correlate well statistically. In this cohort, the true global success satisfaction rate was 92% (chi-square test = 119; p = 0.001 < 0.05) compared to 77% surgical success, based on graft take only. The combination of patient- and surgeon-reported outcomes would be beneficial in reporting true global success in tympanoplasty.
Prevalence of Vertebral Fractures in Adults With Type 1 Diabetes: DenSiFy Study (Diabetes Spine Fractures)
Authors: Coll Julie-Catherine , Garceau Élodie , Leslie William D , Genest Mathieu , Michou Laëtitia , Weisnagel S John , Mac-Way Fabrice , Albert Caroline , Morin Suzanne N , Rabasa-Lhoret Rémi , Gagnon Claudia 
Published: January 2022

Abstract

Context
Vertebral fracture (VF) prevalence up to 24% has been reported among young people with type 1 diabetes (T1D). If this high prevalence is confirmed, individuals with T1D could benefit from preventative VF screening.

Objective
We compared the prevalence of VFs between adults with T1D and nondiabetic controls.

Methods
This cross-sectional study included 127 adults with T1D, and 65 controls with a similar age, sex, and BMI distribution, from outpatient clinics of 2 tertiary care centers. Vertebral fracture assessment (VFA) by dual-energy x-ray absorptiometry (DXA) was used for prevalent VFs. The modified algorithm-based qualitative (mABQ) method was applied. Bone mineral density (BMD) and trabecular bone score (TBS) were assessed by DXA. Serum bone turnover markers and sclerostin were measured in a subgroup of participants.

Results
Participants with T1D (70 women, 57 men) had a mean age of 42.8 ± 14.8 years, median diabetes duration of 25.8 (15.8-34.4) years, mean BMI of 26.6 ± 5.4 kg/m2 and mean HbA1c over the past 3 years of 7.5 ± 0.9%. Controls (35 women, 30 men) had mean age of 42.2 ± 15.9 years and mean BMI of 26.1 ± 5.1 kg/m2. VF prevalence was comparable between groups (2.4% vs 3.1%, P = 0.99). TBS, BMD at the total hip and femoral neck, and bone formation and resorption markers were lower while sclerostin levels were similar in participants with T1D vs controls.

Conclusion
Our VFA results using the mABQ method do not confirm increased prevalence of VFs in men and women with relatively well-controlled T1D.
“My Whole Life I’ve Been on the Run”: Fugitivity as a Postracial Trope inRed Dead Redemption 2
Authors: Marks Katrina 
Published: January 2022

AbstractThis article discusses the popular video game Red Dead Redemption 2 (2018) by Rockstar Games, which follows Arthur Morgan, a white outlaw, during the decline of the “Wild West” in 1898 and 1899. Taking up conversations of fugitivity in critical ethnic studies, this article maintains that fugitivity operates as a rhetorical trope that stands in for racial identity where the logic of postracialism denies investments in race. Analyzing the narrative, spatial, and kinesthetic elements of the game, this article argues that Morgan, and by extension the player, is aligned with historically and geographically racialized others through a fugitive relationship to space. While Rockstar, as a video game studio, may not see itself explicitly intervening in a racialized and racializing political imaginary in its fictional worldbuilding, the kinesthetic, narrative, and cartographic strategies the studio employs respond to a set of cultural assumptions rooted in the rhetoric of postracialism. As such, Red Dead Redemption 2 serves as a multifaceted text through which to interrogate the dynamics of that rhetoric as it is mobilized in representations of fugitivity and identity.
Working Paper 15: Tracking and tracing stolen assets in foreign jurisdictions
Authors: Monteith Charles , Dornbierer Andrew 
Published: January 2022

It has been estimated that roughly 1.6 trillion USD in criminal proceeds are laundered through the international financial system each year. To put this in perspective, this sum is more than the combined GDPs of Switzerland, Portugal, Romania, Belarus, and Austria in 2011.
To enjoy this unnerving amount of illicit assets, criminals are forced to launder these funds through legitimate international financial channels in an attempt to disguise their illegitimate origins. Consequently, if an investigator knows how and where to look, there is always a connection that links a criminal’s assets to his or her crimes – and if sufficient evidence of this connection can be shown, then law enforcers can use it to successfully take legal action and return the assets to the victims of their crime.
This paper appeared in eucrim, the European Criminal Law Associations’ Forum, 2013/2, published by Max Planck Society for the Advancement of Science, c/o Max Planck Institute for Foreign and International Criminal Law, Freiburg i. B., Germany.
Working Paper 26: The ambivalence of social networks and their role in spurring and potential for curbing petty corruption: comparative insights from East Africa
Authors: Kassa Saba , Stahl Cosimo 
Published: January 2022

This paper compares social network dynamics and related petty corrupt practices in East Africa. It highlights how the properties of structural and functional networks could serve as entry points for anti-corruption interventions.
With a focus on the health sector in Rwanda, Tanzania and Uganda, the empirical findings from this research corroborate the role of social networks in perpetuating collective practices of petty corruption, including bribery, favouritism and gift-giving.
The paper makes a case for designing a novel type of behavioural anti-corruption intervention, whereby the power of social networks is harnessed to elicit behavioural and attitudinal change for anti-corruption outcomes.
Working Paper 31: Applying the Swiss Anti-Money Laundering Act to gold refineries
Authors: Mbiyavanga Stefan 
Published: January 2022

Switzerland is the world leader in gold refining. Of the roughly 2,200–3,100 tonnes of raw gold imported into the country each year, the majority is destined for Swiss gold refineries. Together these companies are estimated to refine 50–70 percent of the world’s gold production, transforming it into gold bars, semi-finished products and other goods.
The imported gold loses all traces of its origin during the refining process. Due to the high-quality manufacturing standards of Swiss refineries, and the fact that they possess all of the pertinent accreditations, the gold can afterwards be traded as "Swiss" gold on international financial markets without restrictions.
At the same time, the international gold trade is enormously vulnerable to money laundering operations by drug cartels and other forms of organised crime networks, terrorist organisations, and kleptocrats. As the world centre of gold refining, Switzerland is highly exposed to these money laundering risks.
This Working Paper first analyses money laundering risks in the gold trade, supported by examples. This is followed by an overview of the gold refineries' due diligence obligations under existing self-regulation and the Swiss Anti-Money Laundering Act (AMLA). It is shown that the self-regulation models have, at best, mixed success and that the core business of the refineries is not subject to the AMLA. Finally, the paper sets out the pros and cons of applying the AMLA obligations to the core business of Swiss refineries.
„Skuteczność stosowania fali uderzeniowej w wybranych dysfunkcjach narządu ruchu”
Authors: Momot-Kuryło Magdalena , Grzegorczyk Michał 
Published: January 2022

"Effectiveness of using the shock wave in selected dysfunctions of the musculoskeletal system"
mgr. Magdalena Momot-Kuryło Rehabilitation and Sports Center "Medi-Sport" in Lublin
dr Michał Grzegorczyk Department of Physiotherapy Rehabilitation, Chair of Rehabilitation and Balneotherapy, Faculty of Health Sciences, Medical University of Lublin.

Introduction
In medicine, the shockwave was first used in the 1980s for lithotripsy [1]. Over time, new reports appeared about its positive impact on the human body, including on the musculoskeletal system. Nowadays it is successfully used in many fields of medicine.

Objective of the work
The aim of the study was to evaluate the effectiveness of the shock wave application in patients with patellar ligament enthesopathy, lateral epicondylitis of the humerus and heel spur.

Material and methods
The research was carried out in CM Luxmed, ul. Zwycięska 6a and CM MEDISPORT at ul. Łabędzia in Lublin in the period from 01/12/2020. until December 10, 2021 75 patients took part in them. 25 of them were diagnosed with patellar ligament enthesopathy, another 25 with lateral epicondylitis of the humerus. The remaining 25 people received shock wave treatments for the heel spur. Each respondent underwent 5 shock wave treatments. Before starting the research, the respondents were informed about the purpose of the research. Moreover, they were guaranteed anonymity.

Results:
Among the surveyed people, in general, 50.7% (n = 38) of all respondents were women, and 49.3% (n = 37) - men. 36% (n = 9) women and 64% (n = 16) men were among the respondents treated for lateral epicondylitis of the humerus. In the case of the jumper's knee, the study group consisted of 60% (n = 15) women and 40% (n = 10) men, while in the group of patients with the heel spur, women constituted 56% (n = 14), and men 44% (n = 11).
Science and the Market for Technology
Authors: Arora Ashish , Belenzon Sharon , Suh Jungkyu 
Published: January 2022

Well-functioning markets for technology (MFT) allow inventors to sell their inventions to others that may derive more value from them. We argue that the growing use of science in inventions enhances MFT. Science-based inventions have higher gains from trade and lower transaction costs. This relationship is amplified in equilibrium because science-based inventions are also likely to feature smaller inventors with a greater propensity to trade. Using large-scale data, we show that patents citing science are more likely to be traded, especially for novel patents and for smaller inventors. We conclude that the growing use of science in invention is beneficial by encouraging the expansion of MFT and supporting a division of innovative labor. This paper was accepted by David Simchi-Levi, entrepreneurship and innovation.