bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grape supply chain: Vertical coordination in Ningxia, China
Authors: Li Shuo , Bitsch Linda , Hanf Jon 
Published: November 2022

Abstract. Li S, Bitsch L, Hanf JH. 2021. Grape supply chain: Vertical coordination in Ningxia, China. Asian J Agric 5: 12-21. Since 2018, China has been the second-largest grape-growing country in the world, with 875 thousand hectares in total. A former study indicated a transformation within the wine grape supply chain management in the Chinese wine market, from traditional coordination to significant vertical integration. The Ningxia Helan Mountain’s Eastern Foothill wine region (China) is considered to be the best wine region in China and has potential to lead domestic wine production. This study summarizes the typology of grape supply models in the Ningxia wine industry. We also examine influencing factors for the arrangements of current vertical coordination models of grape materials supply, particularly the hybrid organizations and contractual relationships are analyzed.
Folded beam path architecture for highly efficient filter-based spectral sensors
Authors: Kobylinskiy Aliaksei , Werner Lukas , Kraus Matthias , Hillmer Hartmut , Brunner Robert 
Published: November 2022

This paper demonstrates a method to significantly enhance the detection efficiency of filter-based spectral sensors without the use of additional dichroic optics for spectral preselection. The fundamental principle is that light reflected from one interference filter or filter segment can be used consecutively, reducing the overall system losses. The proof-of-concept is presented using two compact optical modules. The first module uses 10 individual filters between 520 and 800 nm, and the second is capable of continuous spectrum acquisition between 450 and 825 nm using a linear variable filter (LVF) as a key element. An efficiency increase factor of up to approximately 100 compared to a common system, where the entire LVF is directly illuminated, was demonstrated.
Determinants of clinician and patient to prescription of antimicrobials: Case of Mulanje, Southern Malawi
Authors: Chalusa Morris , Khuluza Felix , Bandawe Chiwoza 
Published: November 2022

Background
Antimicrobial resistance is an emerging problem in low- and middle-income countries. The problem is exacerbated by inappropriate prescription of antimicrobials. Factors that lead to overuse or inappropriate prescription of antimicrobials by the cadre of medical assistants, clinical technicians and clinical officers have received limited attention. This study investigated factors that influence prescription behaviours of antimicrobials among clinical officers in various health facilities in Mulanje district, Southern Malawi.

Methods
Qualitative study design exploring determinants of antimicrobial prescription from May to October, 2019, was used. In-depth interviews (n = 18) and focus group discussions (n = 2) were conducted with medical assistant (MA), clinical technicians and clinical officers (CO) from four health facilities in Mulanje district. COs are licensed medical practitioners with an initial three-year training and one-year internship while MAs are licensed medical practitioners with initial two-year training and one year internship. Purposive sampling was done to arrive at a sample size of 30 health cadres.

Results
Participants pointed out that patient preferences, beliefs and clinicians’ inadequate education on this issue were among the factors that contribute to inappropriate antimicrobial prescription. 75% of clinicians showed lack of knowledge on the definition of antibiotic and antimicrobial resistance.

Conclusion
Inappropriate use of antimicrobials is facilitated by prescription decisions made by clinicians who are greatly influenced by their patients. Interventions aimed at improving antimicrobial prescription should target both clinicians and patients.
Potential economic and clinical implications of improving access to snake antivenom in five ASEAN countries: A cost-effectiveness analysis
Authors: Patikorn Chanthawat , Ismail Ahmad Khaldun , Zainal Abidin Syafiq Asnawi , Othman Iekhsan , Chaiyakunapruk Nathorn , Taychakhoonavudh Suthira 
Published: November 2022

Background
Despite domestic production of antivenoms in the Association of Southeast Asian Nations (ASEAN) countries, not all victims with snakebite envenomings indicated for antivenom received the appropriate or adequate effective dose of antivenom due to insufficient supply and inadequate access to antivenoms. We aimed to conduct a cost-effectiveness analysis to project the potential economic and clinical impact of improving access to antivenoms when all snakebite envenomings in ASEAN countries were hypothetically treated with geographically appropriate antivenoms.

Methodology
Using a decision analytic model with input parameters from published literature, local data, and expert opinion, we projected the impact of “full access” (100%) to antivenom, compared to “current access” in five most impacted ASEAN countries, including Indonesia (10%), Philippines (26%), Vietnam (37%), Lao PDR (4%), and Myanmar (64%), from a societal perspective with a lifetime time horizon. Sensitivity analyses were performed.

Principal findings
In base-case analyses, full access compared to current access to snake antivenom in the five countries resulted in a total of 9,362 deaths averted (-59%), 230,075 disability-adjusted life years (DALYs) averted (-59%), and cost savings of 1.3 billion USD (-53%). Incremental cost-effectiveness ratios (ICERs) of improving access to antivenom found higher outcomes but lower costs in all countries. Probabilistic sensitivity analyses of 1,000 iterations found that 98.1–100% of ICERs were cost-saving.

Conclusion/Significance
Improving access to snake antivenom will result in cost-saving for ASEAN countries. Our findings emphasized the importance of further strengthening regional cooperation, investment, and funding to improve the situation of snakebite victims in ASEAN countries.
Caregiver perceptions and experiences of paediatric emergency department attendance during the COVID-19 pandemic: A mixed-methods study
Authors: Appleby Gayle , Papageorgiou Vasiliki , Horter Shona , Wharton-Smith Alexandra , Sajjanhar Tina , Hemeson Anthony , Singogo Emmanuel , Cahill Benjamin , Keers Sophie , Wicksey Lorraine , Emedo Marylyn , Yim Alastair , Nyirenda-Nyang’wa Maggie 
Published: November 2022

BackgroundDuring the early stages of the COVID-19 pandemic, concerns were raised about reduced attendance at hospitals, particularly in paediatric emergency departments, which could result in preventable poorer outcomes and late presentations among children requiring emergency care. We aimed to investigate the impact of COVID-19 on health-seeking behaviour and decision-making processes of caregivers presenting to paediatric emergency services at a National Health Service (NHS) Trust in London.Materials and methodsWe conducted a mixed-methods study (survey and semi-structured interviews) across two hospital sites between November-December 2020. Data from each study were collected concurrently followed by data comparison.ResultsOverall, 100 caregivers participated in our study; 80 completed the survey only, two completed the interview only and 18 completed both. Our quantitative study found that almost two-thirds (63%, n = 62) of caregivers attended the department within two days of their child becoming ill. Our qualitative study identified three major themes which were underpinned by concepts of trust, safety and uncertainty and were assessed in relation to the temporal nature of the pandemic and the caregivers’ journey to care. We found most caregivers balanced their concerns of COVID-19 and a perceived “overwhelmed” NHS by speaking to trusted sources, predominantly general practitioners (GPs).ConclusionCaregivers have adapted their health-seeking behaviour throughout the pandemic as new information and guidance have been released. We identified several factors affecting decisions to attend; some existed before the pandemic (e.g., concerns for child’s health) whilst others were due to the pandemic (e.g., perceived risks of transmission when accessing healthcare services). We recommend trusted medical professionals, particularly GPs, continue to provide reassurance to caregivers to seek emergency paediatric care when required. Communicating the hospital safety procedures and the importance of early intervention to caregivers could additionally provide reassurance to those concerned about the risks of accessing the hospital environment.
The association between physical activity and erectile dysfunction: A cross-sectional study in 20,789 Brazilian men
Authors: Pitta Rafael Mathias , Kaufmann Oskar , Louzada Andressa Cristina Sposato , Astolfi Rafael Haddad , de Lima Queiroga Luana , Ritti Dias Raphael Mendes , Wolosker Nelson 
Published: November 2022

Introduction
Erectile dysfunction, defined as the inability to achieve and/or maintain a penile erection sufficient for satisfactory sexual intercourse is associated with impaired quality of life and cardiovascular diseases in men older than 40 years.

Objective
To evaluate the association between erectile dysfunction and physical activity levels in a large cohort of men.

Methods
Data from 20,789 males aged 40 years and over who participated in the check-up screening between January of 2008 and December of 2018 were included in this study. In this sample, data about erectile dysfunction, physical activity levels, clinical profile and laboratory exams were obtained. Logistic regression models were performed.

Results
Individuals with erectile dysfunction were older (49.1 ±6.9 vs. 54.8±8.8 years old, p<0.001), had a higher body mass index (27.6 ±3.9 vs. 28.5 ± 4.3 kg/m2, p<0,001), and presented with a higher prevalence of physical inactivity (25 vs. 19%, p<0.001) than individuals without erectile dysfunction. The multivariate model revealed that age (p<0.001), hypertension (p = 0.001), diabetes mellitus (p<0.001), high body mass index (p<0.001), lower urinary tract symptoms and depressive symptoms (p<0.001) were independent risk factors for erectile dysfunction. Low or high physical activity levels (OR = 0.77; CI95%: 0.68–0.87, p<0.001 and OR = 0.85; CI95%: 0.72–0.99, p = 0.04 respectively) were protective factors against erectile dysfunction.

Conclusion
Low and high physical activity levels were associated with more than 20% reduction in the risk of erectile dysfunction in men aged 40 years or older.
Cost-consequence of abatacept as first-line therapy in Japanese rheumatoid arthritis patients using IORRA real-world data
Authors: Tanaka Eiichi , Inoue Eisuke , Shoji Ayako , Nilsson Jonas , Papagiannopoulos Christos , Dhanda Devender , Yoshizawa Yuri , Abe Mai , Saka Kumiko , Sugano Eri , Sugitani Naohiro , Ochiai Moeko , Yamaguchi Rei , Ikari Katsunori , Yamanaka Hisashi , Harigai Masayoshi 
Published: November 2022

Objectives
To investigate the cost-effectiveness of abatacept (ABA) as first-line (1L) therapy in Japanese rheumatoid arthritis (RA) patients using data from the Institute of Rheumatology, Rheumatoid Arthritis database.

Methods
A decision-analytic model was used to estimate the cost per American College of Rheumatology response of at least 50% improvement (ACR50) responder and per patient in Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) remission from a Japanese healthcare payers’ perspective over a 2-year time horizon. Clinical characteristics of patients on ABA-1L were matched with those of patients on ABA second or later line (2L+) or tumour necrosis factor inhibitor (TNFi)-1L directly or using propensity scores. Resource utilisation and medical costs were calculated from the Japan Medical Data Center claims database. Parameter uncertainty was addressed by sensitivity and subgroup analyses (age, treatment duration, Japanese version of Health Assessment Questionnaire [J-HAQ] score).

Results
Incremental costs per member per month (ΔPMPM) for ABA-1L versus TNFi-1L and ABA-2L+ were -1,571 Japanese Yen (JPY) and 81 JPY, respectively. For ABA-1L versus TNFi-1L, ΔPMPM by ACR50 response was -11,715 JPY and by CDAI and SDAI remission 11,602 JPY and 47,003 JPY, respectively. Corresponding costs for ABA-1L were lower for all outcome parameters versus those for ABA-2L+. Scenario analyses showed that ABA-1L was cost-effective over TNFi-1L in patients <65 years for any outcome. Furthermore, ABA-1L was cost-effective over ABA-2L+ for all outcomes in patients with age <65 years, disease duration <5 years and J-HAQ ≥1.5.

Conclusions
ABA-1L demonstrated a favourable cost-effectiveness profile in RA patients, accruing savings for the Japanese healthcare payers.
Predictors of large cell transformation in patients with Sezary Syndrome—A retrospective analysis
Authors: Jairath Neil K. , Bardhi Redina , Runge John S. , Bledea Ramona , Jairath Ruple , Wang Yang , Patrick Matthew , Wilcox Ryan A. , Hristov Alexandra C. , Tsoi Lam C. , Tejasvi Trilokraj 
Published: November 2022

Background
Large cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its development.

Objectives
Here, we seek to characterize the clinicopathologic risk factors that predispose patients with SS to develop LCT.

Methods
We retrospectively evaluated all SS patient records available in the Michigan Medicine Cancer Registry from 2010–2021. Clinical and pathologic variables were compared between groups. The Kaplan-Meier method and log-rank test were used to assess overall survival.

Results
Of 28 SS patients identified, eight patients experienced LCT, and 20 did not (NLCT). Peak lactate dehydrogenase (LDH) before LCT (p = 0.0012), maximum total body surface area (TBSA) involvement before LCT (p = 0.0114), absolute CD8+ cell count measured on flow cytometry at diagnosis of SS (p = 0.0455) and at the most recent blood draw (p = 0.00736), and ulceration on biopsy (p = 0.0034) were significant clinicopathologic variables identified between the SS patients that developed LCT versus those that did not.

Conclusions
Maximum TBSA involvement, peak LDH, presence of ulceration, and decreased levels of CD8+ cells in the peripheral blood may predict the development of LCT in patients with SS.
Admission lactate level and the GRACE 2.0 score are independent and additive predictors of 30-day mortality of STEMI patients treated with primary PCI—Results of a real-world registry
Authors: Szabo Dominika , Szabo Andras , Magyar Levente , Banhegyi Gyongyver , Kugler Szilvia , Pinter Anita , Juhasz Vencel , Ruppert Mihaly , Olah Attila , Ruzsa Zoltan , Edes Istvan Ferenc , Szekely Andrea , Becker David , Merkely Bela , Hizoh Istvan 
Published: November 2022

Background
In many of the risk estimation algorithms for patients with ST-elevation myocardial infarction (STEMI), heart rate and systolic blood pressure are key predictors. Yet, these parameters may also be altered by the applied medical treatment / circulatory support without concomitant improvement in microcirculation. Therefore, we aimed to investigate whether venous lactate level, a well-known marker of microcirculatory failure, may have an added prognostic value on top of the conventional variables of the “Global Registry of Acute Coronary Events” (GRACE) 2.0 model for predicting 30-day all-cause mortality of STEMI patients treated with primary percutaneous coronary intervention (PCI).

Methods
In a prospective single-center registry study conducted from May 2020 through April 2021, we analyzed data of 323 cases. Venous blood gas analysis was performed in all patients at admission. Nested logistic regression models were built using the GRACE 2.0 score alone (base model) and with the addition of venous lactate level (expanded model) with 30-day all-cause mortality as primary outcome measure. Difference in model performance was analyzed by the likelihood ratio (LR) test and the integrated discrimination improvement (IDI). Independence of the predictors was evaluated by the variance inflation factor (VIF). Discrimination and calibration was characterized by the c-statistic and calibration intercept / slope, respectively.

Results
Addition of lactate level to the GRACE 2.0 score improved the predictions of 30-day mortality significantly as assessed by both LR test (LR Chi-square = 8.7967, p = 0.0030) and IDI (IDI = 0.0685, p = 0.0402), suggesting that the expanded model may have better predictive ability than the GRACE 2.0 score. Furthermore, the VIF was 1.1203, indicating that the measured lactate values were independent of the calculated GRACE 2.0 scores.

Conclusions
Our results suggest that admission venous lactate level and the GRACE 2.0 score may be independent and additive predictors of 30-day all-cause mortality of STEMI patients treated with primary PCI.
Not Exactly Lying: Fake News and Fake Journalism in American History, Andie Tucher (2022)
Authors: Biggins Felicity 
Published: November 2022

Review of: Not Exactly Lying: Fake News and Fake Journalism in American History, Andie Tucher (2022)
New York: Columbia University Press, 384 pp.,
ISBN 978-0-23118-634-6, h/bk, USD 115.00/GBP 90.00,
ISBN 978-0-23118-635-3, p/bk, USD 28.00/GBP 22.00,
ISBN 978-0-23154-659-1, e-book, USD 27.99/GBP 22.00
Chylous Ascites: Reassessment of Diagnostic Criteria in Patients With Portal Hypertension
Authors: Matchett Caroline L. , Rattan Puru , McConnell Joseph P. , Donato Leslie J. , Simonetto Douglas A. , Kamath Patrick S. 
Published: November 2022

INTRODUCTION:
The triglyceride (TG) threshold for diagnosis of chylous ascites in patients with portal hypertension remains uncertain.

METHODS:
Retrospective analysis of lipoprotein electrophoresis was conducted in 286 consecutive ascites samples.

RESULTS:
Ascitic TG ≥ 81 mg/dL is 95.4% sensitive and 94.6% specific for chylous ascites diagnosed by the presence of significant chylomicron population.

DISCUSSION:
The cutoff for chylous ascites diagnosis should be TG ≥ 81 mg/dL.
Composição florística e diagnose ambiental de um fragmento florestal de Cerrado na bacia hidrográfica do Rio Uberaba
Authors: Gomes Júnior Juarez Antônio , Braga Júnior Aguinaldo José , Milla dos Santos Senhuk Ana Paula 
Published: November 2022

A fragmentação promove a redução do hábitat original, o aumento do número das manchas de vegetação e o distanciamento entre elas, assim compromete as funções ecossistêmicas. O presente estudo caracterizou um fragmento florestal de Cerrado, situado na bacia hidrográfica do Rio Uberaba, Uberaba-MG, quanto às áreas de restrição ambiental, aos impactos ambientais negativos e à flora arbustiva e arbórea. Coletas de exemplares botânicos férteis foram realizadas quinzenalmente por 12 meses em 5 transectos aleatórios. Amostras de ramos com flores e/ou frutos coletadas foram prensadas e secas em estufa para armazenamento na coleção botânica do Herbário de Uberaba (URA). A identificação dos táxons foi feita por meio de chaves de identificação, revisões taxonômicas e consulta a especialistas. Para calcular a similaridade florística com outras áreas na região, foi utilizado o índice de Sörensen. Pelo mapeamento da cobertura e uso alternativo do solo verificou-se a predominância de mata seca (40,39%), cerradão (37,64%) e a presença de paisagens relacionadas às atividades antrópicas, como pastagem com reflorestamento (6,34%) e plantação de eucaliptos (2,04%). Quanto aos impactos ambientais negativos, destacou-se as atividades de motocross que tem compactado o solo e acelerado os processos erosivos. Foram amostradas 82 espécies, distribuídas em 36 famílias, com destaque para Fabaceae (52,7% da diversidade). O fragmento florestal estudado apresentou 14% e 37% de similaridade com outras duas áreas, destacando espécies em comum protegidas por lei como Caryocar brasiliense e Handroanthus chrysotrichus. Os resultados são de grande importância para subsidiar práticas sustentáveis e a tomada de decisões por gestores ambientais locais.
Mucin 13 (MUC13) as a candidate biomarker for ovarian cancer detection: potential to complement CA125 in detecting non-serous subtypes
Authors: Ren Annie H. , Filippou Panagiota S. , Soosaipillai Antoninus , Dimitrakopoulos Lampros , Korbakis Dimitrios , Leung Felix , Kulasingam Vathany , Bernardini Marcus Q. , Diamandis Eleftherios P. 
Published: November 2022

Abstract

Objectives
Ovarian cancer is the most lethal gynecological malignancy in developed countries. One of the key associations with the high mortality rate is diagnosis at late stages. This clinical limitation is primarily due to a lack of distinct symptoms and detection at the early stages. The ovarian cancer biomarker, CA125, is mainly effective for identifying serous ovarian carcinomas, leaving a gap in non-serous ovarian cancer detection. Mucin 13 (MUC13) is a transmembrane, glycosylated protein with aberrant expression in malignancies, including ovarian cancer. We explored the potential of MUC13 to complement CA125 as an ovarian cancer biomarker, by evaluating its ability to discriminate serous and non-serous subtypes of ovarian cancer at FIGO stages I–IV from benign conditions.

Methods
We used our newly developed, high sensitivity ELISA to measure MUC13 protein in a large, well-defined cohort of 389 serum samples from patients with ovarian cancer and benign conditions.

Results
MUC13 and CA125 serum levels were elevated in malignant compared to benign cases (p<0.0001). Receiver-operating characteristic (ROC) curve analysis showed similar area under the curve (AUC) of 0.74 (MUC13) and 0.76 (CA125). MUC13 concentrations were significantly higher in mucinous adenocarcinomas compared to benign controls (p=0.0005), with AUC of 0.80. MUC13 and CA125 showed significant elevation in early-stage cases (stage I–II) in relation to benign controls (p=0.0012 and p=0.014, respectively).

Conclusions
We report the novel role of MUC13 as a serum ovarian cancer biomarker, where it could complement CA125 for detecting some subtypes of non-serous ovarian carcinoma and early-stage disease.
Developing a machine learning prediction algorithm for early differentiation of urosepsis from urinary tract infection
Authors: Su Mingkuan , Guo Jianfeng , Chen Hongbin , Huang Jiancheng 
Published: November 2022

Abstract

Objectives
Early recognition and timely intervention for urosepsis are key to reducing morbidity and mortality. Blood culture has low sensitivity, and a long turnaround time makes meeting the needs of clinical diagnosis difficult. This study aimed to use biomarkers to build a machine learning model for early prediction of urosepsis.

Methods
Through retrospective analysis, we screened 157 patients with urosepsis and 417 patients with urinary tract infection. Laboratory data of the study participants were collected, including data on biomarkers, such as procalcitonin, D-dimer, and C-reactive protein. We split the data into training (80%) and validation datasets (20%) and determined the average model prediction accuracy through cross-validation.

Results
In total, 26 variables were initially screened and 18 were statistically significant. The influence of the 18 variables was sorted using three ranking methods to further determine the best combination of variables. The Gini importance ranking method was found to be suitable for variable filtering. The accuracy rates of the six machine learning models in predicting urosepsis were all higher than 80%, and the performance of the artificial neural network (ANN) was the best among all. When the ANN included the eight biomarkers with the highest influence ranking, its model had the best prediction performance, with an accuracy rate of 92.9% and an area under the receiver operating characteristic curve of 0.946.

Conclusions
Urosepsis can be predicted using only the top eight biomarkers determined by the ranking method. This data-driven predictive model will enable clinicians to make quick and accurate diagnoses.