bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of model organism phenotypes to the computational identification of human disease genes
Authors: Alghamdi Sarah M. , Schofield Paul N. , Hoehndorf Robert 
Published: June 2022

ABSTRACT
Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past decade, cross-species phenotype comparisons have proven valuble, and several ontologies have been developed for this purpose. The relative contribution of different model organisms to computational identification of disease-associated genes is not fully explored. We used phenotype ontologies to semantically relate phenotypes resulting from loss-of-function mutations in model organisms to disease-associated phenotypes in humans. Semantic machine learning methods were used to measure the contribution of different model organisms to the identification of known human gene–disease associations. We found that mouse genotype–phenotype data provided the most important dataset in the identification of human disease genes by semantic similarity and machine learning over phenotype ontologies. Other model organisms' data did not improve identification over that obtained using the mouse alone, and therefore did not contribute significantly to this task. Our work impacts on the development of integrated phenotype ontologies, as well as for the use of model organism phenotypes in human genetic variant interpretation.
This article has an associated First Person interview with the first author of the paper.
Comparison of Gefitinib in the treatment of patients with non-small cell lung cancer and clinical effects of Osimertinib and EGFR Gene mutation
Authors: Li Xiaofeng , Zhai Zhanqiang , Zhu Youcai , Zhou Haiou 
Published: June 2022

Objectives: To compare the clinical effects of Osimertinib and Gefitinib in the treatment of non-small cell lung (NSCLC) complicated with epidermal growth factor receptor (EGFR) gene mutation.
Methods: We retrospectively analyzed the clinical data of 102 patients with advanced NSCLC and EGFR gene mutations treated in the Chest Disease Diagnosis and Treatment Center of our hospital from January 2018 to January 2020. We divided the data based on the administered treatments into Osimertinib and Gefitinib groups. The disease control rate (DCR), progression free survival (PFS) and the incidence of adverse events in both groups were analyzed.
Results: In the Osimertinib group, there was one patients with complete response (CR), 38 with partial response (PR), eight with stable disease (SD), and two with progressive disease (PD)/ The overall response rate (ORR) was 79.59% (39/49), and the disease control rate (DCR) was 95.92% (47/49). In the Gefitinib group, we found zero patients with CR, 37 patients with PR, 11 with SD, and five with PD. The ORR in the Gefitinib group was 69.80% (37/53) and DCR was 90.57% (48/53). There was no statistical significance between the two groups, ORR was χ2=0.927 (P=0.336) and the DCR χ2=0.221 (P=0.638). The median PFS of and Gefitinib groups was significantly higher in the oxitinib group, compared to the Gefitinib group (18.1 months (95% CI 15.4-20.7) and 10.7 months (95% CI 9.9-11.4), respectively, P<0.001). The incidence of adverse reactions in the Osimertinib group was 12.24% (6/49), which was significantly lower than 28.30% (15/53) in the Gefitinib group (P < 0.05).
Conclusions: The clinical effect of oxitinib in the treatment of non-small cell lung cancer complicated with EGFR gene mutation is similar to that of Gefitinib. In patients with advanced NSCLC and EGFR gene mutations, oxitinib treatment is associated with significantly longer PFS and lower adverse reaction rate compared with Gefitinib treatment.
doi: https://doi.org/10.12669/pjms.38.6.5456
How to cite this:Li X, Zhai Z, Zhu Y, Zhou H. Comparison of Gefitinib in the treatment of patients with non-small cell lung cancer and clinical effects of Osimertinib and EGFR Gene mutation. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5456
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparison of two suspension injection tracers of nano activated carbon and methylene blue in mapping and tracing of sentinel lymph nodes of patients with endometrial cancer
Authors: Yang Shuying , Zhang Weifeng , Shu Yan , Ni Dongmei , Wan Zeqiu 
Published: June 2022

Objectives: To analyze the application efficiency of two tracers for sentinel lymph node mapping in patients with endometrial cancer.
Methods: The records of endometrial cancer patients treated in our hospital from July 2019 to July 2021 were selected. Among them, 29 patients received methylene blue suspension injection and 33 patients received nano activated carbon suspension injection. The staining of sentinel lymph nodes was recorded and the application efficiency of two different tracers were analyzed.
Results: Total detection rate, average number of sentinel lymph nodes and bilateral detection rate of nano activated carbon suspension injection were significantly higher than those of methylene blue suspension injection (P<0.05). Detection accuracy, positive predictive value and sensitivity of nano activated carbon suspension injection were significantly higher than those of methylene blue suspension injection (P<0.05). Incidence of complications was the same in the two groups (P>0.05). Tracing time of nano activated carbon suspension injection was significantly lower than that of methylene blue suspension injection, and the total duration was significantly higher than that of methylene blue suspension injection (P<0.05).
Conclusion: Nano activated carbon can obtain good detection effect in sentinel lymph node recognition in endometrial cancer patients, with shorter tracing time and higher total duration than methylene blue suspension.
doi: https://doi.org/10.12669/pjms.38.6.5714
How to cite this:Zhang W, Shu Y, Ni D, Wan Z, Yang S. Comparison of two suspension injection tracers of nano activated carbon and methylene blue in mapping and tracing of sentinel lymph nodes of patients with endometrial cancer. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5714
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Nonverbal communication skills: New-era education needs of younger generation medical students
Authors: Murakami Manabu , Jin Shigeki , Takeuchi Akiko , Matoba Kotaro 
Published: June 2022

doi: https://doi.org/10.12669/pjms.38.6.6058
How to cite this:Murakami M, Jin S, Takeuchi A, Matoba K. Nonverbal communication skills: New-era education needs of younger generation medical students. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.6058
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A large-scale image dataset of wood surface defects for automated vision-based quality control processes
Authors: Kodytek Pavel , Bodzas Alexandra , Bilik Petr 
Published: June 2022

The wood industry is facing many challenges. The high variability of raw material and the complexity of manufacturing processes results in a wide range of visible structure defects, which have to be controlled by trained specialists. These manual processes are not only tedious and biased, but also less effective. To overcome the drawbacks of the manual quality control processes, several automated vision-based systems have been proposed. Even though some conducted studies achieved a higher recognition rate than trained experts, researchers have to deal with a lack of large-scale databases and authentic data in this field. To address this issue, we performed a data acquisition experiment set in the industrial environment, where we were able to acquire an extensive set of authentic data from a production line. For this purpose, we designed and implemented a complex technical solution suitable for high-speed acquisition during harsh manufacturing conditions. In this data note, we present a large-scale dataset of high-resolution sawn timber surface images containing more than 43 000 labelled surface defects and covering 10 types of the most common wood defects. Moreover, with each image record, we provide two types of labels allowing researchers to perform semantic segmentation, as well as defect classification, and localization.
CREM perspective on home office—a consideration of the workplace and its mechanisms of action
Authors: Voll Kyra , Gauger Felix , Pfnür Andreas 
Published: June 2022

AbstractThe effect between the workplace and work success is a black box whose mechanisms have so far received little theoretical substantiation. In the explanation of the importance of corporate real estate and its management for the success of companies, the influence of real estate on the work productivity of employees through the physical workplace is shown. However, the overall picture has not yet been fully elaborated and the fragmentary knowledge is only partially suitable for attributing organizational outcomes to the characteristics of the physical working environment. Without sufficient empirical data and a solid theoretical foundation for physical working environment studies, it is not possible to draw conclusions with sufficient certainty about the impact of working environments on organizational outcomes.The fact that millions of people worldwide are working from home for the first time during the COVID-19 pandemic provides an unprecedented opportunity to explore the impact of the home office environment on business success.This study aims to contribute to filling this research gap by further investigating the impact of the physical working environment at home on productivity by building on the Environmental Demands–Resources model. Therefore, the research goal is to determine which of the four included demands and resources (isolation, family–work interference, equipment/facilities, and building) have an impact on employee burnout and satisfaction, and how this impact affects employee productivity. Partial least squares structural equation modeling is used to analyze a German survey sample (n = 429).The results suggest that the four included workplace characteristics have significant influence, with equipment/facilities and building increasing satisfaction and isolation and family–work interference increasing burnout. Equipment/facilities is identified as the most important factor affecting productivity in the home office.Through this study, a contribution is made to establish a more inclusive and integrative framework for physical working environment research. In addition, the results show that workspace characteristics have an impact on productivity. Far beyond the pandemic, the impact of changes in workspace design on employee perceptions and organizational performance will be important to corporate real estate management practice.
Factors that influence older patients’ participation in clinical communication within developed country hospitals and GP clinics: A systematic review of current literature
Authors: Gaffney Harry James , Hamiduzzaman Mohammad 
Published: June 2022

Background
Engaging older adults in clinical communication is an essential aspect of high-quality elder care, patient safety and satisfaction in hospitals and GP clinics. However, the factors that influence older adults’ participation during their appointments with health professionals from the older patient’s perspective remain under-investigated.

Objectives
We aimed to fill this knowledge gap by reviewing research articles that have examined older patients’ involvement in clinical communication. In doing so, we hope to assist healthcare professionals and institutions in developing new strategies to improve older patients’ participation and engagement in clinical communication.

Methods
A systematic review of nine databases was conducted for studies reporting identified influences on older patients’ participation in clinical communication published from 2010. These studies were then subjected to thematic analysis for stratification.

Results
Twenty-one articles with a total of 36,797 participants were included and highlighted three major themes that influenced older patients’ participation in the clinical communication. The first theme identified includes accessibility to appointments, support, health information and person-centred care, highlighting that access to appointments, person centred care and health information significantly influences clinical communication participation. Relevant and understandable healthcare information identified that communication factors [i.e. tailored health information, health literacy and patient language barriers, and communication impairments] influences older patients’ participation. Older Patient perceptions of HCP credibility and trustworthiness highlighted how patient’s perceptions of health professionals influence their willingness to participate in clinical communications.

Conclusions and implications
This review demonstrates that there are several factors that contribute to insufficient or no participation of older patients in clinical communication in hospitals and GP clinics. These include accessibility to relevant and understandable health information, and the perceived health professional credibility and trustworthiness. Identifying ways to address these factors may improve patient participation, doctor-patient collaboration and overall health outcomes for older patients.
LA PROHBICIÓN DE LA AUTOMATIZACIÓN DECISORIA BASADA EN EL PERFILAMIENTO DIGITAL
Authors: Muñoz Ricardo 
Published: June 2022

Contextualización: La Inteligencia Artiﬁ cial (IA) genera, produce, implica y representa desafíos para los derechos humanos, tanto que aquella debe concretar un “alineamiento” con estos, y los sistemas inteligentes no pueden producir interferencias con la dignidad humana. Por eso, la manipulación ﬁnal y operación sobre procesos de IA, debe descansar en personas (y más aún todavía cuando los resultados impactan directamente sobre las libertades), debiendo –en deﬁ nitiva- “la dimensión humana” estar presente en el proceso de toma de decisiones y evaluación sobre quejas ante situaciones de violaciones a los derechos humanos.
Objetivo: El objetivo de la investigación es identiﬁ car que derechos fundamentales pueden ser afectados por las tecnologías inteligentes, analizando los usos de estas tecnologías y su repercusión sobre los derechos, por un lado, y la necesidad de delimitar su contenido deﬁ niendo garantías, por el otro.
Metodología: La investigación utilizó el método inductivo aliado a la base lógica inductiva para expresar los resultados.
Resultado: Desde nuestra óptica, la prohibición estudiada no alcanza a toda la automatización de las decisiones administrativas y/o judiciales por medio del uso de IA en el marco de un procedimiento previo llevado a cabo por la Administración pública o el Poder Judicial.
Clinical Improvement With Pyridostigmine in a Patient With Acetylcholine Receptor Antibody-Associated Autoimmune Gastrointestinal Dysmotility
Authors: Sekhri Shaina , Massey Benson , Beniwal-Patel Poonam 
Published: June 2022

ABSTRACT
Autoimmune gastrointestinal dysmotility (AGID) is a rare form of limited autoimmune dysautonomia caused by autoantibodies against the enteric nervous system. Our patient was a 53-year-old man with 1 year of bloating, intolerance of oral intake, and recurrent ileus. Esophageal manometry showed aperistalsis and hypotensive lower sphincter, consistent with scleroderma esophagus. However, because the patient had no other sequelae of this disease, AGID was considered. Serologic evaluation revealed ganglionic acetylcholine receptor autoantibodies. Treatment with pyridostigmine led to resolution of symptoms. Early recognition of AGID should be considered when manometry shows scleroderma esophagus in patients without other evidence of systemic sclerosis.
Impact of esophageal mucosal permeability markers on provocation‐induced esophageal reflexes in high‐risk infants
Authors: Jadcherla Sudarshan R. , Helmick Roseanna , Hasenstab Kathryn A. , Njeh Minna , Alshaikh Enas 
Published: June 2022

AbstractEsophageal distal baseline impedance (DBI) is an indicator of mucosal integrity; lower values suggest increased permeability. Aims were to characterize the (1) effect of DBI category (<900 Ω, 900–2000 Ω, and >2000 Ω) on sensory‐motor characteristics of mid‐esophageal provocation‐induced motility reflexes, and (2) clinical outcomes among high‐risk human infants evaluated for gastroesophageal reflux disease. Symptomatic infants (N = 49, 41 ± 3 weeks postmenstrual age) underwent pH‐impedance testing to characterize acid reflux index (ARI) and DBI, and pharyngo‐esophageal manometry to examine upper esophageal sphincter (UES), peristaltic, and lower esophageal sphincter (LES) functions. Sensory‐motor response characteristics included response threshold (ml), occurrence (%), latency (s), duration (s), and magnitude (mmHg) upon mid‐esophageal stimulations (0.1–2.0 ml of air, water, and apple juice). Motility and clinical outcomes were compared among DBI groups. In infants with DBI <900 Ω and 900–2000 Ω (vs. >2000 Ω): (a) Long‐term feeding milestones did not differ (p > 0.05); (b) complete peristaltic propagation decreased in 900–2000 Ω (p < 0.05), polymorphic waveforms increased in <900 Ω and 900–2000 Ω (p < 0.05); (c) media effects were noted with liquids (vs. air) wherein UES and esophageal contractility were prolonged in <900 Ω and 900–2000 Ω (p < 0.05), and esophageal sensitivity heightened for <900 Ω with water and for 900–2000 Ω with air (both p < 0.05). ARI was not correlated with DBI in infants with chronic lung disease (r = 0.05, p = 0.82). We conclude that pharyngo‐esophageal motility sensory‐motor characteristics in infants are modified by DBI category. These preliminary findings pave‐the‐way for further physiological testing in convalescing high‐risk infants to ascertain potential mechanisms of airway‐digestive reflex interactions and symptom generation, which may lead to targeted therapies.
Public service media as drivers of innovation: A case study analysis of policies and strategies in Spain, Ireland, and Belgium
Authors: Direito-Rebollal Sabela , Donders Karen 
Published: June 2022

Abstract
In the post-broadcast era, public service media (PSM) organizations have to innovate, stay up-to-date with new ways of consuming content, and experiment with the manifold opportunities that interactivity offers for audience engagement. At the same time, they are still obligated to achieve their public service remit and guarantee that services comply with values such as universality, diversity, creativity, and innovation. This article analyzes the innovation policies and strategies of PSM to understand if these are shifting from a technology-centric to a user-centric approach. It evaluates what areas of innovation are prioritized by both policy-makers and public broadcasters and whether these areas correspond with the innovation goals entrusted to PSM organizations by scholars. To this end, we adopted a multi-case study approach. The focus is on three public broadcasters of varying size and situated in different political, cultural, and economic backgrounds: RTVE (Spain), RTÉ (Ireland), and VRT (Belgium). Based on a qualitative document analysis, we conclude that innovation remains largely technology-centric. Strategies are oriented to the implementation of new technologies, the digital distribution of the content, and the collaboration with external partners. However, these public broadcasters have not yet promoted concrete actions to encourage the participation of their audiences.
The Evolving Esthetics of Hong Kong Films in the 21st Century
Authors: Zhao Weifang 
Published: June 2022

Abstract
Since the 21st century, great changes have taken place in film co-productions between Hong Kong and the mainland and local films in Hong Kong. Since the signing of the Closer Economic Partnership Arrangement (CEPA) in 2003 between the two regions, co-production between Hong Kong and the mainland moved from a state of maladjustment to mutual exchange and integration. However, a crisis of narrative homogenization arose around 2010, but this situation was remedied by anti-homogenization efforts through adding films of suspense genre. Around 2015, a “new mainstream blockbuster” connecting the performance of mainland mainstream values and esthetics emerged in co-productions, successfully carrying out a mainland replacement of extant blockbusters that commonly featured Hong Kong-style humanistic values and esthetics. Hong Kong local films are also undergoing esthetic evolution in the context of the cultural conservation of Hong Kong people. First, a return can be witnessed to classic “Hong Kong’s flavor” films such as gangster and ghost films, inheriting and innovating the traditional “Hong Kong’s flavor” esthetic. Secondly, we can observe Hong Kong society and its changing history from a cultural perspective through a consideration of the changing film esthetic. After many changes, Hong Kong films have entered a new esthetic form.
Quantification of methods used in field metallography using the example of quality assurance measures for a circular economy for high-alloy steels
Authors: Kronenberg P. , Wieczorek L. , Weber S. L. , Röttger A. 
Published: June 2022

Abstract
This study aims to develop a method for on-site metallography, enabling the characterization of carbide banding in cold-work steels via cellulose acetate film replication. It will be demonstrated that for this purpose, it is sufficient to grind the sample surface using P1500 mesh SiC abrasive paper and etch it with V2A etchant or nitric acid for 7 minutes. By sample preparation and etching, the matrix of the parent material is sufficiently removed for the carbides to leave a “negative” impression on the film. This negative replica can then be studied under reflected light microscope, enabling the characterization of carbide banding.
The Rise of Scientific Materialism and Its Long-Term Effect on the Development of German Theology
Authors: Gooch Todd 
Published: June 2022

Abstract
In diesem Aufsatz wird den Enfluss der steigenden kulturellen Autorität des naturwissenschaften Erkenntnisses auf die Entwicklung der deutschen evangelishen Theologie im Laufe des 19. Jahrunderts untersucht mit besonderer Rücksicht auf Albrecht Ritschl und seine theologische Nachfolger, Wilhelm Herrmann, Ernst Troeltsch, und Rudolf Otto. Dieser Einfluss besteht nicht in erster Linie in den direkten Antworten dieser Theologen auf die Behauptungen der Vertreter verschiedener nicht-theistischen Weltanschuungen, sondern vielmehr in der Übernahme philosophischer Begriffe und Argumentationsmittel, die ihre eigenen theologischen Programme unterschiedlich geformt haben.