bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labor dystocia and oxytocin augmentation before or after six centimeters cervical dilatation, in nulliparous women with spontaneous labor, in relation to mode of delivery
Authors: Brüggemann Cecilia , Carlhäll Sara , Grundström Hanna , Blomberg Marie 
Published: February 2022

Abstract
Background: The effects of diagnosing and treating labor dystocia with oxytocin-infusion at different cervical dilatations are not fully evaluated. Therefore, we aimed to examine whether cervical dilatation at diagnose of dystocia and initiation of oxytocin-infusion was associated with mode of birth, obstetric complications and women’s birthing experience.Method: A retrospective cohort study, performed in a low cesarean section setting, included 588 nulliparous term women with spontaneous onset of labor and dystocia requiring oxytocin augmentation. The study population was divided into three groups according to cervical dilatation at diagnose of dystocia and initiation of oxytocin-infusion (≤5 cm, 6-10 cm, fully dilated) with mode of birth as the primary outcome. Secondary outcomes were obstetrical and neonatal complications and women´s experience of childbirth. The risk of operative birth was assessed using binary logistic regression with suitable adjustments (maternal age, body mass index and risk assessment at admission to the labor ward). The 6-10cm group was set as reference. Results: Cesarean section was performed in 12% in the ≤5 cm group, 6% in the 6-10 cm group and 0% in the fully dilated group (p<.001), with no differences in the instrumental birth rates (11-14%, p=.569). There was no increased risk for operative birth (cesarean and vacuum) in the ≤5 cm group compared to the 6-10 cm group, adjusted OR 1.28 (0.78-2.08). The fully dilated group had a decreased risk of operative birth (adjusted OR 0.48 95% CI 0.27-0.85). The rate of a negative birthing experience was high in all groups (28.5%, 19% and 18% ) and the risk was increased among women in the ≤5 cm group compared with the 6-10 cm group, adjusted OR 1.76 (95% CI 1.05-2.95). Conclusions: Women with dystocia requiring oxytocin augmentation diagnosed in second stage of labor had an increased chance of spontaneous vaginal birth compared with women requiring oxytocin augmentation in the late first stage of labor. No differences were shown between early and late active phase of first stage of labor concerning operative birth. Although, women with dystocia requiring oxytocin augmentation at ≤5 cm cervical dilatation seemed to have an increased risk of a negative birth experience.
Energy Efficient Solar Photovoltaic System
Authors: Awasthi Meenakshi 
Published: February 2022

Abstract
Photovoltaic panels gather solar power and transform it into electricity. Solar cells are adjusted at a fixed angle making them less efficient. Solar cell’s competence could be enhanced through designing a tracking system that automatically changes the spot of the PV panels in line with the movement of the sun. A solar tracking system traces both axis which is elevation and azimuth, a two-axis tracking system hold more solar intensity by tracing the motion of the sun in all flanks. The motive of project is to make our solar panels more efficient with the help of a tracking system including an Arduino controller, two motors with the arrangement of the gearbox mechanical structure rotate the solar cell next to sun, so that the sun's rays can stay aligned with the solar cell, all the sensors attached to adjacent sides of the module, using these sensors the system of tracking the sun makes a lot of sense and all helps to determine the precise spot of the Phoebus. The solar collector changes direction according to the intensity calculation. As the temperature of solar panels increase its overall efficiency decreases. Therefore, for this we add a device which is capable of cooling the panels. We add one more device to protect the battery from overcharging and from fluctuation of power generated by solar panels. We add IOT to determine the power output from solar and control the panel manually. It also helps to solve problem of asset management.
Global transportation infrastructure exposure to the change of precipitation in a warmer world
Authors: Liu kai , Wang Qianzhi , WANG Ming , Koks Elco 
Published: February 2022

Abstract
Transportation infrastructures are generally designed to have multi-decadal service lives. The design of transport infrastructure, however, is largely based on historical conditions. Yet in the face of global warming, climatic variables are likely going to have more intense and frequent extreme events, and this would put infrastructures at severe risk. In this study, we undertake a comprehensive analysis of the exposure of transportation infrastructure assets to changes in precipitation return periods globally. Under RCP8.5, 44.45%/58.64% (1.5oC/2.0oC) of the transportation assets will experience a reduction in the return period ratio of more than 25%. Eastern North America, Northern Western Europe, Central Europe and East Asia experience the highest absolute exposure to changes in precipitation return periods, mainly attributed to their dense transportation networks. We recommend considering future climate change effect during transportation infrastructure design process by introducing a design amplification factor, which is a more robust variable compared to return period change ratio.
The association of long-term calcium and dairy products intake in adolescence with carotid intima media thickness and metabolic syndrome in early adulthood: Tehran Lipid and Glucose Study
Authors: AkbarySedigh Assa , Asghari Golaleh , Mahdavi Maryam , Mirmiran Parvin , Azizi Fereidoun 
Published: February 2022

Abstract
Background: Calcium could impact on vascular functions and structures and cause atherosclerosis. Thus, we aimed to examine the association of long-term calcium and dairy products intake in adolescence with cIMT and MetS in early adulthood.Methods: We considered 217 adolescents aged 12-18 years in the frame work of the Tehran Lipid and Glucose Study (2006-2009) and follow-up them to early adulthood (2015-2017). The valid food frequency questionnaire was used to assess dietary intake. Ultrasound examination was used to measure common carotid artery. The joint interim statement and cook et al criteria were used for adults and adolescents to consider MetS, respectively. Results: Adolescents’ average calcium intake from dairy and non-dairy sources were 395 mg/d and 1088 mg/d, respectively while adults had 212 mg/d and 1191 mg/d. In addition, the mean of cIMT in adults was 0.54 mm. There was no relationship of non-dairy (β: -0.03; P=0.804), and total calcium (β: -0.001; P=0.591) intake with cIMT and TG. None of the dairy products had link with cIMT, MetS and its components, except cream with cIMT after full adjustment of potential confounders (β:0.245; P=0.009). Also, we found that the intake of non-dairy products could increase DBP after controlling for potential confounders (β:0.365; P=0.012). Adolescence with higher quartiles of total calcium intake had no odds ratio of MetS in early adulthood (β:2.05, P=0.371).Conclusions: Adolescence calcium and dairy products intake, with the exception of cream did not increase early adulthood cIMT and MetS and its components.
Work-related stress and associated factors among employees of Hawassa industrial park, southern Ethiopia: an institutional-based cross-sectional study.
Authors: sime yohannes , Hailesillassie Hailemariam , Alenko Arefayne 
Published: February 2022

Abstract
Background: Work-related stress (WRS) is becoming an alarmingly growing public health concern worldwide. Due to globalization and changes in working conditions, people in low-income countries face growing WRS. However, despite high prevalence globally, WRS among industrial park workers is not well studied in Ethiopia.Thus; the aim of this study was to assess work-related stress and associated factors among employees of Hawassa industrial park, southern Ethiopia.Methods: An institutional-based cross-sectional study was employed among 419 employees of Hawassa industrial park using an interviewer-administered structured questionnaire. Study participants were selected using simple random sampling technique. Data was collected by face-to-face interview. A workplace stress scale (WPSS) was used to assess work-related stress. The collected data were coded and entered into EPI data 4.6 and exported to SPSS version 26 for analysis. Multivariable logistic regression analysis was conducted to identify associated factors. The statistical significance was considered at P-value <0.05.Result: The Overall prevalence of work-related stress was 47.5%, 95% CI (43.2, 52.1). Variables such as temporary employment [AOR=0.41, 95% CI (0.26-0.64)], poor working condition [AOR = 2.12, 95% CI (1.32-3.43)], work experience <21/2yr [AOR = 3.11, 95% CI (1.95-4.96)], poor learning opportunity [AOR= 1.82, 95% CI (1.10-2.30)], poor organizational support [AOR = 1.70, 95% CI (1.10-2.62)], current use of khat [AOR = 2.52, 95% CI (1.28-4.99)] and current use of alcohol [AOR = 2.27, 95% CI (1.44-3.58)] were significantly associated with work-related stress.Conclusion and recommendation: The study found high prevalence of work-related stress among employees of Hawassa industrial park. Temporary employment, poor working conditions, work experience <21/2 years, poor learning opportunities, poor organizational support, current khat use, and current use of alcohol were significantly associated with work-related stress. Our study finding is recommending enhancing stress management skills and primary prevention on identified risk factors to industry employees.
Overexpression of Heat Shock Protein 90α in Canine Mammary Tumors.
Authors: Bhardwaj Himalaya , Kumar B V Sunil , Singh Chanchal , Gupta Kuldip , Kumar Ashwani , Singh Digvijay 
Published: February 2022

Abstract
Canine mammary gland tumor is the most patronize and dangerous type of tumor diagnosed by histopathology and requires a surgical approach. Hsp90α, a member of the heat shock protein-90 family that found to be over-expressed in breast cancer. However, biological function is unknown in the canine mammary tumor. So, we focused on studying the expression of hsp90AA1 and protein in canine mammary tumor (CMT) tissue. Expression of hsp90AA1 mRNA and protein were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC), respectively. High levels of hsp90AA1 mRNA expression (4.613 ± 0.49 times) were observed in CMT compared to age and breed-matched healthy controls. Further, expression of hsp90α protein was detected in paraffin-embedded mammary tumor tissues from the same subjects by IHC. A high level of hsp90α expression was scored in 75% of the CMT subjects. Moreover, no significant differences in IHC score and qRT-PCR score with respect to CMT histotypes were observed, indicating that Hsp90AA1 over-expression occurred irrespective of CMT types or grades.
The Association of Metabolic Syndrome with the Initiation of Antidepressive Agents: Real-World Data Analysis of Administrative Claims and Health Examinations
Authors: Imaizumi Takahiro , Toda Takuya , Maekawa Michitaka , Sakurai Daisuke , Hagiwara Yuta , Yoshida Yasuko , Ando Masahiko , Maruyama Shoichi 
Published: February 2022

Abstract
Depression and metabolic syndrome (MetS) are correlated, leading to an increased healthcare burden and decreased productivity. We aimed to investigate the associations of medical conditions, including MetS and lifestyle, with depression, using a health checkup and claims database. Individuals aged 18–64 years who underwent health examinations between 2014 and 2019 were enrolled in the study. Among 81,269 participants, “ever” and “incident” antidepressant users exhibited worse metabolic profiles and underwent more prevalent cancer-related hospitalization than “never” users. In a nested case-control study with a 1:10 ratio of incident users to controls, MetS (odds ratio, 1.29 [95% confidence interval: 1.08–1.54]); “quicker” (0.69 [0.59–0.81]) and “late” eating speed (1.25 [1.07–1.46]), as compared with “normal”; poor sleep (1.41 [1.25–1.60]); “sometimes” (0.85 [0.73–0.98]) and “everyday” drink (0.78 [0.66–0.92]), as compared with “rarely drink”; and hypnotic (1.97 [1.47–2.64]), anxiolytic (3.55 [2.79–4.51]), and nonsteroidal anti-inflammatory drug (1.65 [1.18–2.32]) use were associated with incident antidepressant use. A bodyweight increase >10 kg from age 20 years (1.29 [1.14–1.46]) was also significantly associated with incident antidepressant use. In conclusion, metabolic abnormalities, hospitalization records, and lifestyle information can be useful in identifying populations at high risk of depression.
SHED-derived Exosomes Ameliorate Hyposalivation Caused by Sjögren Syndrome via Akt/GSK-3β/Slug-mediated ZO-1 Expression
Authors: Du Zhihao , Wei Pan , Jiang Nan , Wu Liling , Ding Chong , Yu Guangyan 
Published: February 2022

Abstract
Objective: To explore the therapeutic role and mechanism of exosomes obtained from the supernatant of stem cells derived from human exfoliated deciduous teeth (SHED-exos) in sialadenitis caused by Sjögren syndrome (SS).Methods: SHED-exos were administered to the submandibular glands (SMGs) of 14-week-old nonobese diabetic (NOD) mice, an animal model of the clinical phase of SS, by local injection or intraductal infusion. The saliva flow rate was measured after pilocarpine intraperitoneal injection in 21-week-old NOD mice. Protein expression was examined by Western blot analysis. Exosomal miRNAs were identified by microarray analysis. Paracellular permeability was evaluated by transepithelial electrical resistance measurement.Results: Local injection of SHED-exos significantly increased saliva secretion and alleviated lymphocytic infiltration in the SMGs of NOD mice. The injected SHED-exos could be taken up by glandular epithelial cells and increased ZO-1 expression. Moreover, SHED-exos increased paracellular permeability, whereas this effect disappeared in ZO-1 knockout cells and reappeared in ZO-1-rescued cells. Furthermore, 180 exosomal miRNAs were identified from SHED-exos, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested that the PI3K/Akt pathway might play an important role. SHED-exos treatment induced the downregulation of p-Akt/Akt, p-GSK-3β/GSK-3β, and Slug and the upregulation of ZO-1 in SMGs and SMG-C6 cells. Both the increased ZO-1 expression and paracellular permeability induced by SHED-exos were abolished by IGF1, a PI3K agonist. In addition, Slug bound to the ZO-1 promoter and suppressed its expression. For safer and more effective clinical application, SHED-exos were intraductally infused into the SMGs of NOD mice, and saliva secretion was increased and accompanied by decreased levels of p-Akt/Akt, p-GSK-3β/GSK-3β, and Slug and increased ZO-1 expression.Conclusion: Local application of SHED-exos in SMGs can ameliorate Sjögren syndrome-induced hyposalivation by increasing the paracellular permeability of glandular epithelial cells through Akt/GSK-3β/Slug pathway-mediated ZO-1 expression.
What does not kill you makes you peaceful: non-lethal fungal infection could reduce aggression towards strangers in ants
Authors: Csata Eniko , Casacci Luca , Ruther Joachim , Bernadou Abel , Heinze Jürgen , Marko Balint 
Published: February 2022

Abstract
Many parasites interfere with the behaviour of their hosts. In social animals, such as ants, parasitic interference can cause changes on the level of the individual and also on the level of the society. The ant-parasitic fungus Rickia wasmannii influences the behaviour of Myrmica ants by expanding the host’s nestmate recognition template, thereby increasing the chance of the colony accepting infected non-nestmates. Infected ants consistently show an increase of the alkane tricosane (n-C23) in their cuticular hydrocarbon profiles. Although experimental application of single compounds often elicits aggression towards manipulated ants, we hypothesized that the increase of n-C23 might underlie the facilitated acceptance of infected non-nestmates. To test this, we mimicked fungal infection in M. scabrinodis by applying synthetic n-C23 to fresh ant corpses and observing the reaction of infected and uninfected workers to control and manipulated corpses. Infected ants appeared to be more peaceful towards infected but not uninfected non-nestmates. Adding n-C23 to uninfected corpses resulted in reduced aggression by uninfected ants. This supports the hypothesis that n-C23 acts as a “pacifying” signal. Parasitic interference with the nestmate discrimination of host ants might eventually change colony structure by increasing genetic heterogeneity and thus might significantly affect social evolution.
Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending
Authors: Park Yongsoo , Moussa Houda Yasmine , Shin Kyung Chul , Tong Yongfeng , Mansour Said , Kim Soo Jin Soo Jin , Ryu Je-Kyung 
Published: February 2022

Abstract
Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly understood. Here we show that cholesterol is required for Ca2+-dependent fusion using the in-vitro reconstitution of vesicle fusion, atomic force microscopy (AFM), and amperometry to monitor exocytosis in chromaffin cells. Purified native vesicles were crucial for the complete reconstitution of physiological Ca2+-dependent fusion, whereas vesicle-mimicking liposomes failed to reproduce the cholesterol effect. Intriguingly, cholesterol had no effect on membrane insertion of synaptotagmin-1, a Ca2+ sensor for ultrafast fusion. Cholesterol stabilizes local membrane bending induced by synaptotagmin-1 insertion, thereby lowering the energy barrier for Ca2+-dependent fusion to occur. Our data provide evidence that cholesterol depletion abolishes Ca2+-dependent vesicle fusion by disrupting synaptotagmin-1-induced membrane bending, and suggests that cholesterol is a master regulator for Ca2+-dependent fusion.
High strain rate characterisation of soda-lime-silica glass and the effect of residual stresses
Authors: Meyland Martin Jensen , Nielsen Jens Henrik 
Published: February 2022

Abstract
A ring-on-ring test configuration for the equibiaxial flexural testing of flat samples was developed and integrated into a novel modified split-Hopkinson pressure bar (SHPB) setup. The established modifications enabled the application of high-speed cameras for fracture assessment and non-contact displacement measurements using stereo digital image correlation (stereo-DIC). In the present paper, this setup was utilised to characterise the flexural surface strength and stiffness (Young's modulus) of circular, as-received soda-lime-silica glass samples at high strain rates. The effect of residual stresses was also studied by including thermally tempered glass samples divided into four residual stress groups. Despite the frequent application of glass products in the built environment, often post-processed into tempered or laminated glass, these investigations are still rare and thus highly demanded when designing for extreme events such as extreme weather, ballistic impacts, or blast loads. A total of 315 samples were tested at a quasi-static and a dynamic loading rate ranging from 2.0 MPa s -1 to 4.2·10 6 MPa s -1 . It was found that the flexural strength of the glass across residual stress groups was strongly dependent on the applied dynamic loading rate, while the residual stresses themselves showed no significant effect on the loading rate dependency. At the dynamic loading, the strength increased between 60 and 86 %. Within the two tested loading rates, strength increased expectedly with compressive surface stress. From the stereo-DIC displacement measurements, no change in Young's modulus with loading rate was observed.
Factors Associated With Compliance to the Recommendations for Postpartum Diabetes Mellitus Screening Among Women With Gestational Diabetes Mellitus
Authors: Yahav Lior , Salem Shimrit Yaniv , Sandler-Rahat Hadar , Baumfeld Yael , Kaul Kamal , Weintraub Adi Yehuda , Eshkoli Tamar 
Published: February 2022

Abstract
Objective: Since women with GDM have an increased risk to develop type 2 DM, a 75g OGTT is recommended 6-12 weeks postpartum for all women with GDM. However, screening rates remain low. The aim of this study was to find factors affect the rate of postpartum DM screening.Materials and methods: A retrospective cohort study between 2016 and 2017 at the Soroka Medical Center, comparing women with GDM who underwent postpartum DM screening test to those who didn't. Results: 257 women who had a diagnosis of GDM and met the inclusion criteria were included. 53 (20.6%) had a postpartum DM screening test and 204 (79.4%) did not complete the postpartum DM screening.Women who underwent a DM screening postpartum were more likely to be older, with significantly higher rates of vacuum assisted delivery, more likely to be diagnosed with GDMA2 as compared to GDMA1 during pregnancy and, with high probability of receiving recommendations for screening at a postpartum visit. Conclusions: The rates of postpartum DM screening for women with GDM are low and need to increase. Age greater than 25, vacuum delivery, GDMA2 and having received a recommendation for postpartum screening increased the likelihood of undergoing a postpartum DM screening.
Stress–strain and acoustic emission characteristics of cement-based materials used to simulate soft rock with fractures
Authors: Liu Handong , Liu Jingjing , Zhang Shiying , Feng Lingyun , Qiu Lei 
Published: February 2022

Abstract
Instability failure in rock mass engineering is closely related to the expansion of joint fissures. In this study, uniaxial compression tests and acoustic emission (AE) measurements were simultaneously carried out on soft rock-like material with different angle and connectivity of fractures to better understand their influence on soft rock-like deformation and failure. The stress– strain curve and AE signal of fractured soft rock-like material exhibit similar stages as intact soft rock; namely a compaction stage, elastic deformation stage, stable fracture development stage, and unstable fracture development stage. The main differences occur within the post-peak failure stage. Under the combined influence of fracture angle and connectivity, the uniaxial compressive strength of fractured soft rock-like material (f'cu) is lower than that of the intact soft rock-like material (fcu) to varying degrees and can be described as f'cu =fcu• α , where α is the strength reduction coefficient, fitted as α = 0.8228 + 0.00411x―0.00789y. In this equation, x is the fracture angle (°) and y is the fracture connectivity rate (%). Under uniaxial compression, secondary cracks caused by the deformation and failure of the fractured soft rock-like specimens mainly included wing cracks and secondary coplanar cracks. The specimen with a fracture angle of 30° mainly underwent tensile failure under loading, whereas the specimens with 45° and 60° fracture angle mainly underwent shear failure under high-connectivity conditions (45%).