bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process Development and Optimization of Wastewater Derived Integrated Biorefinery for Production of Bio-Based Energy Carriers Employing Spirodela polyrhiza
Authors: Riaz Fatima , Ali Sidra , Perveen Saleha , Irfan Muhammad , Ali Mahwish , Khan Samiullah , Shah Aamer Ali , Ahmed Safia , Jamal Asif , Badshah Malik 
Published: July 2022

Abstract
The excesssive use of agrochemicals to fulfill the high demand of agricultural products has been imposing numerous negative impacts on the environment for decades worldwide. Untreated wastewater with high chemical load and unutilized nutrients of fertilizers and pesticides released from agricultural farms results in contamination and intoxication of clean water bodies. Giant duckweed specifically Spirodela polyrhiza specie has shown the potential to efficiently uptake nutrients from nutrient rich waters thus, it can be employed cost-effective approach for phytoremediation of agricultural runoff. S. polyrhiza biomass also serves as an alternative feedstock for the production of biofuels which is another precedence of using this method. In this study, the potential of S. polyrhiza for removing nitrogen and phosphates from the agricultural runoff was determined by growing it in the agricultural runoff under lab conditions. Upto 70% and 78% removal of nitrogen and phosphates respectively was achieved during the treatment of agricultural runoff by Spirodela polyrhiza. The starch content of Spirodela polyrhiza was elevated 58% during 10–12 days of nutrient starvation at the end of the agricultural runoff treatment process. The biomass obtained was pretreated with dilute acid that liberated 96.4% glucose from the starch-rich biomass. This glucose was used as a substrate for the fermentation process carried out by Saccharomyces cerevisiae QG1 MK788210 yeast strain which yielded 99% volumetric conversion of glucose into bioethanol. The remaining fermentation vinnasse was anaerobically digested and 589 Nml/g VS biogas yield was obtained. To the best of our knowledge this is the first study that develops a lab-scale bioprocess in terms of integrated wastewater derived S. polyrhiza biorefinery.
Helicobacter pylori Infection Eradication on Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial
Authors: Yu Ying-ying , Tong Yu-ling , Wu Ling-yan , Yu Xin-yan 
Published: July 2022

Abstract
Previous studies have found that Helicobacter pylori (H. pylori) infection is associated with nonalcoholic fatty liver disease (NAFLD). The purpose of the present study was to investigate the effect of H. pylori eradication treatment on NAFLD patients. Two hundred NAFLD patients who tested positive for H. pylori infection were randomized into the H. pylori eradication treatment group or the control group. Metabolic and inflammatory parameters and FibroScan were measured in all subjects at baseline and 1 year after treatment. At 1 year after treatment, the decrease in metabolic indicators, such as fasting blood glucose, glycosylated haemoglobin, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides, body mass index and controlled attenuation parameter (CAP) value, were more obvious in the treatment group. Moreover, the inflammatory indicators white blood count (WBC) and high-sensitivity C-reactive protein (hs-CRP) and the inflammatory factors Interleukin 6 (IL-6) and Tumor necrosis facter-α(TNF-α) were also significantly decreased. H. pylori eradication can further reduce the metabolic indices of NAFLD and the degree of liver steatosis. H. pylori infection may participate in the occurrence and development of NAFLD through its influence on inflammatory factors. Thus, checking for the presence of H. pylori infection in patients at risk of NAFLD may be beneficial.
Activated carbon nanofiber nanoparticles incorporated electrospun polycaprolactone scaffolds to promote fibroblast behaviors for application to skin tissue engineering
Authors: Choi Sangmun , Raja Iruthayapandi Selestin , Selvaraj Aravindha Raja , Kang Moon Sung , Hyon Suong-Hyu , Han Dong-Wook , Park Jong-Chul 
Published: July 2022

Abstract
The most widely used one-dimensional (1D) carbonaceous nanomaterials in tissue engineering are carbon nanotubes, either single or multiwalled. Other forms of 1D nanomaterials, such as carbon nanowires and carbon nanofibers, have been less explored for biomedical applications. Herein, we synthesized 1D activated carbon nanofiber nanoparticles (ACNF NPs) from the polyacrylonitrile electrospun nanofibers by continuous processes like stabilization, alkali treatment, calcination and grinding. Two different sets of ACNF NPs-containing electrospun polycaprolactone (PCL) nanofiber mats, viz. surface-modified NPs-deposited mats (ACNF@PCL) and NPs-incorporated mats (ACNF-PCL), were prepared to examine their potential as skin tissue engineering scaffolds. We studied physicochemical characterizations such as Raman and X-ray diffraction spectra to confirm the prepared ACNF NPs. Scanning electron microscopy (SEM) observations showed that ACNF NPs are sized 280 ± 100 nm by diameter and 565-3322 nm by length. The NPs concentrated above 30 µg/mL were found to exhibit toxicity with <70 % viability of NIH3T3 fibroblasts on 48 h. The ACNF-PCL nanofiber mats displayed better cell proliferation profile showing significant changes compared to PCL and ACNF@PCL mats on days 1, 3, and 5. Hence, we concluded that ACNF-PCL mats with less concentration of ACNF NPs have more potential to support cellular growth, ensuring its possible impact on skin tissue regeneration.
Optimization on Video Super Resolution using Predictive Analytics with Machine Learning Concepts
Authors: S Safinaz , Rekha K Bhanu 
Published: July 2022

Abstract
For particular image super-resolution, HR image is assessed by discovering natural image priors and self-similarity surrounded by image and for video super resolution. Similarly, spatial information through positions and temporal information through frames could be used to develop specifics for LR frame. Objective: So far several research works has been carried out in this area of research and this current research aims to develop an effective hybrid RNN-ACO algorithm for enhancing the video super resolution. Data description: To examine the performance metrics, the research is carried out in PYTHON tool which shows the accuracy of proposed approach. Deployment of hybrid RNN-ACO model to improve the video super resolution framework will be implemented and the evaluation parameters such as F-Score, Precision, Recall, Fscore, accuracy, resolution level, Structural Similarity Index (SSIM), IFC, VII, and FII will be analysed and compared for individual RNN and ACO and combined RNN-ACO model.
Influence of perioperative fluid balance on clinical outcomes after hepatic resection in patients with left ventricular diastolic dysfunction
Authors: Shin Jungho , Suh Suk-Won 
Published: July 2022

Abstract
BackgroundMaintenance of low central venous pressure (CVP) during hepatic resection to minimize intraoperative blood loss requires compensative administration of large amounts of fluid after its completion. However, this fluid challenge may influence on the postoperative outcomes of patients with left ventricular diastolic dysfunction (LVDD) who cannot tolerate volume adjustment.MethodsA total of 206 patients with who underwent hepatic resection between March 2015 and February 2021 were evaluated. LVDD was defined according to the American Society of Echocardiography and the European Association of Cardiovascular Imaging 2016 recommendations as LVDD (group A, n = 39), or normal LV diastolic function and indeterminate decision (group B, n = 153).ResultsCVP at the end of surgery was significantly higher in group A than in group B (6.35 ± 3.45 vs. 5.12 ± 2.80, P = 0.025). Postoperative acute kidney injury (AKI, 10.3% vs. 1.3%, P = 0.004) and pleural effusion or edema (51.3% vs. 30.1%, P = 0.013) were more common in group A than in group B. Further, creatinine levels from postoperative day 1 to day 7 were significantly higher and daily urine outputs at postoperative day 1 (P = 0.038) and day 2 (P = 0.025) were significantly lower in group A than in group B. LVDD was the only significant risk factor for postoperative AKI after hepatic resection (odds ratio, 10.181; 95% confidence interval, 1.570-66.011, P = 0.015).ConclusionThe rates of renal dysfunction and pulmonary complications after hepatic resection are higher in patients with LVDD than in those with normal LV diastolic function. Thus, these patients require delicate fluid management.
The Causal Relationship Between White Blood Cells Counts and Hepatocellular Carcinoma: A Mendelian Randomization Study
Authors: Pan Guo-Qiang , Yang Chun-Cheng , Shang Xiao-Ling , Dong Zhao-Ru , Li Tao 
Published: July 2022

Abstract
Background
Studies have reported that 90% of hepatocellular carcinoma (HCC) arise and progress on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumor initiation, progression and clinical response to treatment. Whether white blood cells (WBC) subtypes counts increase or decrease the occurrence of HCC remains unclear.
Methods
In this study, we made a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted from a recent large GWAS of the European ancestry individuals. We obtained GWAS data which related to HCC from UK Biobank (UKB). We performed univariable and multivariable MR analysis to identify whether genetic evidence of risk factors was significantly associated with HCC risks.
Results
In discovery dataset, multivariable MR analysis revealed that among the 8 traits of WBC counts, sum basophil neutrophil counts had an independent causal effect on occurrence of HCC. Sum basophil neutrophil counts: (OR = 0.437, P = 0.003, CI: 0.252–0.757). Similarly, in validation dataset, it was also observed that sum basophil neutrophil counts was the independent risk factor for HCC. Sum basophil neutrophil counts: (OR = 0.574, P = 0.021, CI: 0.358–0.920).
Conclusion
In European population, genetically-predicted the lower sum basophil neutrophil counts might be an independent risk factor of HCC.
WITHDRAWN: Effects of wall heat conduction properties on the methanol reforming process characteristics of microchannel reactors for hydrogen production
Authors: Chen Junjie 
Published: July 2022

Abstract
This study relates to a thermochemical process for producing hydrogen by the catalytic endothermic reaction of methanol with steam in a thermally integrated microchannel reforming reactor. Computational fluid dynamics simulations are conducted to better understand the consumption, generation, and exchange of thermal energy between endothermic and exothermic processes in the reactor. The effects of wall heat conduction properties on the methanol reforming process characteristics of microchannel reactors for hydrogen production are investigated. Particular emphasis is placed on the dependence of heat transfer characteristics on wall heat conduction properties in various situations, with an attempt to improve the distribution of thermal energy for use in microchannel reforming reaction systems for hydrogen production. The results indicate that the reactor design suffers from a fundamental limitation resulting from the flow configuration in which a reacting stream flows parallel to a heat transfer surface through which the majority of heat is transferred perpendicular to the direction of fluid flow. The thermal conductivity of the channel walls is fundamentally important. Materials with high thermal conductivity are preferred for the channel walls. Thermally conductive ceramics and metals are well-suited. Wall materials with poor heat conduction properties degrade the reactor performance. Balancing the heat requirements of an endothermic reaction with heat generated by an exothermic reaction flowing parallel to and on the opposite side of a separating plate is extraordinarily difficult. Along the flow length of the plate that divides exothermic and endothermic reactions, the heat flux through the plate that is perpendicular to fluid flow will vary due to temperature and reaction rate differences along the flow length of the plate.
A new method of amblyopia treatment in children with unstable central and eccentric fixation using biofeedback
Authors: Tarutta E. P. , Khubieva R. R. , Milash S. V. , Apaev A. V. , Aklaeva N. A. , Zolnikova I. V. 
Published: July 2022

Purpose. To develop a new method of amblyopia treatment in children with unstable central and eccentric fixation by centralizing visual fixation and increasing retinal photosensitivity in the macular region using biofeedback. Material and methods. The study included 27 patients (27 eyes) with amblyopia of various origins, aged 5 to 17 (averagely 9.15 ± 3.19 years), who were able to perform training sessions on the MP-3 Nidek microperimeter (Japan). In addition to standard examination, all patients underwent binocular status assessment using a four-point test, macular electroretinography, microperimetry, optical coherence tomography (OCT). The treatment, carried out on the microperimeter using visual (flickering checkerboard pattern) and sound signal biofeedback, consisted of 10—15 sessions, 10—12 minutes each. All patients were examined before treatment cycle, immediately upon the end of the cycle, and also 1 and 3 months after it. Results. Preliminary results showed an increase in best corrected visual acuity (BCVA) from 0.41 ± 0.24 to 0.68 ± 0.27 (33.9 %), the photosensitivity of the retina in the fovea increased from 27.07 ± 3.90 to 29.8 ± 3.3 dB (10 %), fixation density in the central region from 59.80 ± 31.08 to 72.05 ± 34.5 %(20.4 %) with its amplitude decreased by more than two times. After treatment, unstable central fixation changed to stable central fixation in all cases. With eccentric fixation, the fixation point shifted closer to the central region, and fixation characteristics improved in 75 % of cases. The obtained results retained throughout the observation period which lasted up to 3 months. Conclusion. The proposed new treatment method of amblyopia with impaired fixation of various degrees proved to be effective and safe and can be recommended for use in pediatric patients.
Clinical and morphological aspects of the development of secondary ophthalmic hypertension in uveal melanoma
Authors: Grishina E. E. , Setdikova G. R. , Kim I. D. , Bogatyrev A. M. , Loskutov I. A. , Eremeeva E. R. 
Published: July 2022

Ophthalmic hypertension is mostly associated with medium- or large-sized melanomas. The pathogenesis of persistent IOP elevation in uveal melanoma is not fully understood at present. Purpose. To analyze the clinical and morphological mechanisms of the development of secondary ophthalmic hypertension in patients with uveal melanoma. Material and methods. The case histories of 26 patients with T3N0M0-T4N0M0 uveal melanoma were analyzed retrospectively from 2015 to 2019. The main group included 18 patients with secondary monolateral IOP elevation while the control group was composed of 8 patients with normal IOP. Tumors in both groups were comparable in size. All patients underwent eradication treatment (enucleation/exenteration). Enucleated eys were histologically examined. Results. Pronounced pathological changes of the iridocorneal angle, iris and ciliary body were found morphologically in all specimens with elevated IOP. The following dominating mechanisms ofophthalmic hypertension were detected: iris and anterior chamber angle neovascularization; tumor-associated chronic uveitis; obstruction of trabecular meshwork by cellular elements (pigment-rich macrophages, blood cells, inflammatory cells); fibrosis and deformation of trabecular meshwork and Schlemm's canal; closed angle glaucoma with lens-iris diaphragm shift; tumor invasion into the angle. Conclusions. Investigation of morphological changes in patients with UM and found resemblances with already studied non-tumor forms of glaucoma may help find previously undetectable receptors for the development of targeted anti-tumor drugs.
Remote functional and anatomical results of idiopathic macular hole surgery performed without postsurgical vitreous cavity tamponade
Authors: Kleymenov A. Yu. , Kazaykin V. N. , Lizunov A. V. 
Published: July 2022

Purpose. To assess remote results of our method of macular hole (MH) surgery without postsurgical vitreous cavity tamponade. Material and methods. 34 eyes of34 patients were operated for full-thickness MH 100 to 932 (558.5 ± 50.9) microns in diameter with no vitreous cavity tamponade. Before surgery, best corrected visual acuity (BCVA) was 0.02 to 0.25 (0.11±0.02). The operation included 3-port 25—27 G vitrectomy, separation of posterior hyaloid membrane, staining and removal of the internal limiting membrane (ILM) with subsequent ex­change of salt solution for air. The hole edges were passively (without touching the retina) pulled towards the center using an extrusion cannula through air supplied into the vitreous cavity under the pressure of 20—25 mm Hg. After that, 0.05 to 0.1 ml of platelet rich plasma (PRP) of the patient was applied to macular hole zone. In 2 minutes, a fibrin film was formed at the place of application which was pressed to the retina by injecting 0.5 ml of Perfluororganic Compound liquid (PFCL) into the vitreous cavity. PFCL was exposed for 3 minutes, whereupon it was passively aspirated. The operation was completed by air exchanged for salt solution. High specific weight of PFCL facilitated a tight adhe­sion of fibrin film to the retina. The follow-up period was 1 to 20 months (7.9±0.8 on average). Results. After the surgery, complete closure of the macular hole was achieved in 32 of 34 cases (94.1%). No intraoperative or postoperative complications were observed. Postsurgical BCVA improved to 0.3—0,7(0.50 ± 0.05). At the initial stage of the study, a recurrence ofMH took place in two cases associated with partial mechanical displacement of the fibrin film by the cannula during PFCL removal. Conclusions. The proposed method of macular hole surgery avoiding postoperative vitreous cavity tamponade with gas or another vitreous substitute is effective, speeds up the rehabilitation and may be used in routine clinical practice, especially in patients with the only seeing eye, those with a transparent lens, those who need to take a plane or rise at great heights soon after the surgery, as well as those at risk of increased IOP or unable to sustain a forced head position even for a short time span.
Optimization of diagnostics of retinopathy of prematurity stages based on the integration of clinical data using the Key to Diagnosis I software
Authors: Pererva O. A. , Kovalevskaya M. A. 
Published: July 2022

Despite the improvement of algorithms of preterm infants’ management, methods for predicting, diagnosing and treating ROP remains a vital issue. Purpose: to improve the diagnostics of retinopathy of prematurity based on the assessment of vascular system configuration, using Key to Diagnosis I software. Material and methods. 279 patients with ROP were divided into 6 groups: group 1 included 152 patients (304 eyes) with stage I; group 2 — 45patients (90 eyes) with stage II; group 3 — 8patients (12 eyes) with stage III; group 4 — 7 patients (8 eyes) with stage IVA; group 5 — 7 patients (14 eyes) with posterior aggressive ROP; control group 6 — 60patients (120 eyes) diagnosed with immature retina who have no ROP signs. 28 eyes were analyzed using wide-field imaging, while 400 eyes were analyzed by separate images. The presence o f“mute” zones, macula localization, traction index of the macular zone (Tm), zone and span of pathological changes, fractal dimension (Df) and complexity of vascular system (СVS) were assessed on automatically created wide-field images, obtained by Ret-Cam Shuttle. Results. We revealed strong correlation between Df and stages (p = 0.85, p = 0.01); moderate negative correlation of Тm and stages (p = 0.62, p = 0.01), except for posterior aggressive ROP; strong positive correlation between CVS and stages ( p = 0.91, p = 0.001). Diagnostic modules of the software have been developed to create wide-field fundus imaging in infants, localize the macula as a marker for morphometry, and isolate the vascular system using deep convolutional neural networks. Conclusions. The developed algorithm for multivari­ate analysis of the retinal vascular system reduces the risks of subjective assessment of retinal changes.
Performance of carbendazim removal using constructed wetlands for the Ethiopian floriculture industry
Authors: Wehbe Stan , Zewge Feleke , Inagaki Yoshihiko , Sievert Wolfram , Uday Kumar N.T. , Deshpande Akshay 
Published: July 2022

Abstract
Carbendazim is a pesticide commonly used in Ethiopian flower farms and has harmful effects on aquatic, invertebrate, and mammalian life. Previous studies have explored ways to remedy carbendazim toxicity; however, the use of constructed wetland (CW) systems for carbendazim removal from farm water runoff has not been explored in depth. The primary aim of this study was to investigate the efficacy of a CW system for carbendazim removal from wastewater runoff. A two-stage pilot CW was built and tested for its efficacy of carbendazim removal under saturated conditions and varying hydraulic loading rates. The influent was pumped into the first vertical-flow mesocosm. The drained water was then pumped into the second mesocosm. The collected effluent was tested for carbendazim removal. Carbendazim removal efficiencies up to 91.80% (with a hydraulic loading rate of 100 Ld−1 and influent carbendazim concentration of 10 μg L−1) were observed. Statistical analysis indicated that the removal of carbendazim was not correlated with the initial carbendazim concentration but was negatively correlated with the hydraulic loading rate used. Two pesticide removal mechanisms were briefly probed to determine their participation in carbendazim removal. Substrate sorption accounted for 18% of total carbendazim removal; furthermore, plant uptake also played an active role.
The recent fluvial fan of Lorca (Murcia) and its transition to the Guadalentín River: geological controls during the latest Pleistocene-Holocene
Authors: García-Mondéjar Joaquín , Martínez Rodríguez Andrés , Ponce García Juana 
Published: July 2022

The fluvial fan of Lorca (Murcia) (AFL acronym in Spanish), located in the Guadalentín depression to the SE of the city, is approximately 11.5 km long, 9 km wide and 19 m maximum thick, and is presently cut by the Guadalentín river. Data from 17 excavations in the city and its surroundings revealed the presence of silts and channelized sands and gravels in the proximal fan, and tabular silts and clays in both the mid and distal fan. The age of the unit is latest Pleistocene - Holocene and the age of its excavation early Holocene. Incision of the fan head stopped more than 5000 years ago, when the Guadalentín river reached approximately 13 m below the fan surface at the fan apex, and three main erosional terraces were formed. The fan was formed during the change from glacial to interglacial conditions by subsidence in the basin, enhanced by sedimentary loading and compaction of the pre-fan series. Transition from fan to river is attributed to downthrow of the Guadalentín depression to NE of Lorca. This is demonstrated by fan thickness distribution, fan-base and internal beds tilting, palaeocurrents shift, erosional meander formation, tectonic activity in both Alhama de Murcia fault and Guadalentín river blind fault, and headward erosion in Viznaga rambla. The end of the last endorheism in Lorca in early Holocene, and in the rest of Guadalentín depression during the late Holocene, suggests transpression and transtension effects increased by unloading processes in adjacent areas, and probably flexion by loading in the Mediterranean platform after Pleistocene ice melting.