bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200 mg/kg of exogenous surfactant make?
Authors: Lanciotti Lucia , Correani Alessio , Pasqualini Matteo , Antognoli Luca , Dell'Orto Valentina G. , Giorgetti Chiara , Colombo Sara , Palazzi Maria L. , Rondina Clementina , Burattini Ilaria , Carnielli Virgilio P. 
Published: May 2022

AbstractBackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.Study DesignA retrospective single‐center cohort study comparing two epochs, before and after switching from 100 to 200 mg/kg surfactant therapy.ResultsSix hundred and fifty‐eight of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100 mg/kg (S‐100) and 376 received 200 mg/kg (S‐200). There were no differences between S‐100 and S‐200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.The S‐200 vs. S‐100 had fewer retreatments (17.0% vs. 47.2%, p < 0.001) and a shorter duration of oxygen therapy and mechanical ventilation (315 vs. 339 h, p = 0.018; 37 vs. 118 h, p = 0.000, respectively). There was no difference in postnatal corticosteroid use (S‐200 10.0% vs. S‐100 11.0%, p = 0.361). Bronchopulmonary dysplasia (BPD) was significantly lower in S‐200 vs. S‐100 when comparing either the 4 and 6‐year periods before and after the dose switch (29.4% vs. 15.7%, p = 0.003, and 18.7% vs. 27.3%, p = 0.024, respectively)ConclusionsThe switch from 100 to 200 mg/kg was associated with a marked reduction in the need for surfactant redosing, respiratory support, and BPD. This information could be important when designing a study in the modern era of less invasive administration as surfactant dosing and its effective delivery may affect the outcome.
Chronic lung disease in full‐term infants: Characteristics and neonatal intensive care outcomes in infants referred to children's hospitals
Authors: Mikhael Michel , Cleary John P. , Zaniletti Isabella , Truog William E. , Ibrahim John , DiGeronimo Robert , Cuna Alain , Kielt Matthew J. , Coghill Carl H. , Vyas‐Read Shilpa , Yallapragada Sushmita , Engle William A. , Savani Rashmin C. , Murthy Karna , Lagatta Joanne M. ,   Children's Hospitals Neonatal Consortium (CHNC) Severe BPD Focus Group
Published: May 2022

AbstractObjectiveTo describe characteristics, outcomes, and risk factors for death or tracheostomy with home mechanical ventilation in full‐term infants with chronic lung disease (CLD) admitted to regional neonatal intensive care units.Study DesignThis was a multicenter, retrospective cohort study of infants born ≥37 weeks of gestation in the Children's Hospitals Neonatal Consortium.ResultsOut of 67,367 full‐term infants admitted in 2010–2016, 4886 (7%) had CLD based on receiving respiratory support at either 28 days of life or discharge. 3286 (67%) were still hospitalized at 28 days receiving respiratory support, with higher mortality risk than those without CLD (10% vs. 2%, p < 0.001). A higher proportion received tracheostomy (13% vs. 0.3% vs. 0.4%, p < 0.001) and gastrostomy (30% vs. 1.7% vs. 3.7%, p < 0.001) compared to infants with CLD discharged home before 28 days and infants without CLD, respectively. The diagnoses and surgical procedures differed significantly between the two CLD subgroups. Small for gestational age, congenital pulmonary, airway, and cardiac anomalies and bloodstream infections were more common among infants with CLD who died or required tracheostomy with home ventilation (p < 0.001). Invasive ventilation at 28 days was independently associated with death or tracheostomy and home mechanical ventilation (odds ratio 7.6, 95% confidence interval 5.9–9.6, p < 0.0001).ConclusionFull‐term infants with CLD are at increased risk for morbidity and mortality. We propose a severity‐based classification for CLD in full‐term infants. Future work to validate this classification and its association with early childhood outcomes is necessary.
The roles of highly conserved, non‐catalytic residues in class A β‐lactamases
Authors: Chikunova Aleksandra , Ubbink Marcellus 
Published: May 2022

AbstractEvolution minimizes the number of highly conserved amino acid residues in proteins to ensure evolutionary robustness and adaptability. The roles of all highly conserved, non‐catalytic residues, 11% of all residues, in class A β‐lactamase were analyzed by studying the effect of 146 mutations on in cell and in vitro activity, folding, structure, and stability. Residues around the catalytic residues (second shell) contribute to fine‐tuning of the active site structure. Mutations affect the structure over the entire active site and can result in stable but inactive protein. Conserved residues farther away (third shell) ensure a favorable balance of folding versus aggregation or stabilize the folded form over the unfolded state. Once folded, the mutant enzymes are stable and active and show only localized structural effects. These residues are found in clusters, stapling secondary structure elements. The results give an integral picture of the different roles of essential residues in enzymes.
An update on the current status and future prospects of erectile dysfunction following radical prostatectomy
Authors: Asker Heba , Yilmaz‐Oral Didem , Oztekin Cetin Volkan , Gur Serap 
Published: May 2022

AbstractBackgroundRadical prostatectomy (RP) and radiation treatment are standard options for localized prostate cancer. Even though nerve‐sparing techniques have been increasingly utilized in RP, erectile dysfunction (ED) due to neuropraxia remains a frequent complication. Erectile function recovery rates after RP remain unsatisfactory, and many men still suffer despite the availability of various therapies.ObjectiveThis systematic review aims to summarize the current treatments for post‐RP‐ED, assess the underlying pathological mechanisms, and emphasize promising therapeutic strategies based on the evidence from basic research.MethodEvaluation and review of articles on the relevant topic published between 2010 and 2021, which are indexed and listed in the PubMed database.ResultsPhosphodiesterase type 5 inhibitors, intracavernosal and intraurethral injections, vacuum erection devices, pelvic muscle training, and surgical procedures are utilized for penile rehabilitation. Clinical trials evaluating the efficacy of erectogenic drugs in this setting are conflicting and far from being conclusive. The use of androgen deprivation therapy in certain scenarios after RP further exacerbates the already problematic situation and emphasizes the need for effective treatment strategies.ConclusionThis article is a detailed overview focusing on the pathophysiology and mechanism of the nerve injury developed during RP and a compilation of various strategies to induce cavernous nerve regeneration to improve erectile function (EF). These strategies include stem cell therapy, gene therapy, growth factors, low‐intensity extracorporeal shockwave therapy, immunophilins, and various pharmacological approaches that have induced improvements in EF in experimental models of cavernous nerve injury. Many of the mentioned strategies can improve EF following RP if transformed into clinically applicable safe, and effective techniques with reproducible outcomes.
New qPCR protocol to detect Diplodia corticola shows phoretic association with the oak pinhole borer Platypus cylindrus
Authors: Muñoz‐Adalia Emigdio Jordán , Meijer Andreu , Colinas Carlos 
Published: May 2022

AbstractBACKGROUNDBotryosphaeria canker (causal agent: Diplodia corticola) is considered one of the most important diseases of cork oak (Quercus suber) stands since it necrotizes the subero‐phellodermic layer preventing cork regeneration after harvesting. One of the most intriguing etiological issues of this disease is its plausible spreading through trunk borer insects. In this study, we highlight the phoretic relationship between D. corticola and the oak pinhole borer Platypus cylindrus (Coleoptera, Curculionidae) which massively colonizes debarked cork oaks in southern Europe. We extracted DNA from 154 adults of P. cylindrus collected in six cork oak stands in north‐eastern Spain during the summer of 2021. We developed a new nested quantitative PCR‐based protocol for quick detection of D. corticola carried by insects.RESULTSThe use of real time amplification of a highly specific mitochondrial marker allowed us to detect spore loads down to a single conidium within the first 29 cycles of qPCR. The 29.62% of insect pools (corresponding to 31.16% of studied insects) resulted in an estimated spore load higher than one conidium/insect, with a moderate value of mean spore load for the whole dataset (~33 conidia/insect). Estimated spore load was significantly higher in May and August, regardless of insect abundance in the field.CONCLUSIONThis study provides new tools for diagnosis of this emergent pathogen that would be useful for developing monitoring strategies and epidemiological studies. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A novel virtual cutting method for deformable objects using high‐order elements combined with mesh optimisation
Authors: Wang Monan , Ma Yuzheng , Liu Fengjie 
Published: May 2022

AbstractBackgroundVirtual cutting of deformable objects plays an important role in many applications, especially in digital medicine, such as soft tissue cutting in virtual surgery training system.MethodsWe developed a novel virtual cutting algorithm, combined with mesh optimisation. A new local mesh processing method is used to control the number and quality of the elements created during the cutting process. At the same time, high‐order tetrahedral elements are used to fit the cutting surface and reduce the mesh size.ResultsIn this paper, single cut, multiple cut and intersecting cut are performed on the mesh model, combined with a force feedback device, and the result obtained is that the visual feedback is higher than 30 Hz, and the tactile feedback is 800∼1000 Hz.ConclusionsExperimental results show that the method proposed in this paper can effectively eliminate low‐quality elements and control the mesh size, thereby ensuring real‐time simulation.
Promoting equity in the peer review process of journal publication
Authors: Bancroft Senetta F. , Ryoo Kihyun , Miles Monica 
Published: May 2022

AbstractWhile there is evidence to support the existence of identity‐based disparities, inequities, and biases in the academic journal peer‐review process, little research supports the presence of this bias in the peer‐review process for academic journals in science education. Through an analysis of six leading journals in science education, we aimed to investigate the extent to which diversity, equity, and inclusion (DEI), as well as the presence of bias in the peer‐review process, are addressed by these journals. We analyzed trends in the gender/sex, geographical affiliation, race/ethnicity, and the presence of equity‐centered research focus for members of these journals' editors and editorial boards. We found that although gender/sex is well‐balanced in these journals' editors and editorial boards, they are typically North American centric, and White individuals are overwhelmingly represented. Four journals had a quarter or more of individuals who pursue equity‐centered research. Only two journals provided detailed information on how manuscripts are reviewed in their author submission guidelines. All used a double‐blind approach to peer‐review. One of the journals includes an explicit position on DEI. Based on the analyses and reflections on our own experiences, we recommend science education journals consider ways to probe whether bias does exist in their peer‐review process, diversify their board to be more inclusive of scholars from communities historically marginalized, and move to a triple‐blind approach to their peer‐review process as mechanisms to mitigate bias in the journal peer review.
Burden of Treatment in Vulval Lichen Sclerosus
Authors: O’Grady Ciara , O’Connor Cathal , Al Moosa Aysha , Murphy Michelle , Nic Dhonncha Eilis 
Published: May 2022

Abstract
Lichen sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the anogenital region, which can have significant impact on quality of life. Burden of treatment (BOT) is defined as the workload of healthcare experienced by patients and consequences on well-being. In this prospective study, 35 women with vulval LS completed a detailed Treatment Burden Questionnaire to assess their BOT. Nineteen (54.3%) achieved a score of 35 or less, signifying low BOT; ten (28.6%) between 36 and 65, signifying moderate BOT; and six (17.1%) above 65, signifying high BOT. Seven (20%) patients reported BOT scores of greater than 59, which has been designated as a cut-off for increased risk of treatment-related burnout. Higher BOT scores were moderately correlated with higher DLQI scores (r = 0.47, p &lt; 0.01). BOT in LS is low for most patients, although a minority are at risk of treatment-related burnout. BOT should be considered when forming treatment guidelines for LS.
Novel Naphthalimide‐Based Self‐Assembly Systems with Different Terminal Groups for Sensitive Detection of Thionyl Chloride and Oxalyl Chloride in Two Modes
Authors: Han Qingqing , Wang Qingqing , Wu Huijuan , Ge Xuefei , Gao Aiping , Bai Yifan , Gao Siyu , Wang Guixia , Cao Xinhua 
Published: May 2022

AbstractTwo novel naphthalimide derivatives‐based chemosensors with the terminal groups of ethanediamine and 1,3‐diaminopropane (1 and 2) were designed and synthesized. Two compounds exhibited obvious solvatochromism properties. They could respond to some kinds of acyl chlorides through reaction with the ethylenediamine group and propylene diamine group at 4‐site. It was found that they had different response performance due to their different terminal groups. Compound 1 could sensitively detect thionyl chloride (SOCl2) and oxalyl chloride ((COCl)2) with the low limit detection (LOD) of 29.54 nΜ and 151.6 pM in the solution state, respectively. Moreover, film 1 could also respond to the abovementioned acyl chloride gases with LOD of 35.5 and 91.98 ppb, respectively. It was different that compound 2 could selectively detect (COCl)2 with a low LOD of 243.4 pM and 35 ppb for its solution and film state, respectively. NMR and HRMS experiments well demonstrated that the different detection mechanism occurred on two sensors. From this work, it was concluded that the little difference between the terminal reaction sites of naphthalimide greatly affected the detection performance, which would open a window for design functional self‐assembly sensors for acyl chlorides based on naphthalimide derivatives.
Pyrazolyl‐Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
Authors: Koca İrfan , Kamaci Volkan , Özsoy Ceylan , Sert Yusuf , Kani İbrahim , Tutar Lütfi , Tutar Yusuf 
Published: May 2022

AbstractHeat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to fold faster than normal folding rate. Although, the process leads cell cycle halting and eventually induces apoptosis, Hsps help cell survival and inhibit apoptosis and fold substrate proteins especially signaling proteins. When cancer cells accelerate the metabolism for invasion and metastasis, substrate proteins must fold to their native state rapidly. Since, functional forms of the proteins must be folded properly, cancer cells overexpress Hsps to fold substrate proteins and avoid apoptosis. Hsp90 and Hsp70 play key role in these processes. Inhibition of either Hsp90 or Hsp70 display complementary function. Therefore, dual inhibition of Hsp70 and Hsp90 potentially provides anticancer affect. In silico studies showed that pyrazolyl‐benzoxazine derivatives display binding activity for both Hsps. For this purpose, pyrazole‐3‐carbonyl chloride were converted to pyrazolyl‐benzoxazine derivatives via reactions of anthranilic acids in good yields (68–83 %). The structures of the newly synthesized compounds were elucidated by IR‐NMR spectroscopy, elemental analysis, and single‐crystal X‐ray diffraction. Binding of the compounds inhibit function of Hsps and cause cytotoxic effect over MCF‐7 cells. The compounds display potential anticancer effects.
Synthesis, Characterization, Molecular Docking, Acetylcholinesterase and α‐Glycosidase Inhibition Profiles of Nitrogen‐Based Novel Heterocyclic Compounds
Authors: Gulcin İlhami , Petrova Olga V. , Taslimi Parham , Malysheva Svetlana F. , Schmidt Elena Yu. , Sobenina Lyubov N. , Gusarova Nina K. , Trofimov Boris A. , Tuzun Burak , Farzaliyev Vagif M. , Alwasel Saleh , Sujayev Afsun R. 
Published: May 2022

AbstractIn this study, a series of nitrogen‐based novel heterocyclic compounds were synthesized and characterized by elemental analysis, IR and NMR spectra. The novel synthesized nitrogen‐based novel heterocyclic compounds were evaluated against the acetylcholinesterase (AChE) and α‐glycosidase enzymes. These compounds showed IC50 values in range of 0.76–28.04 μM against AChE as a cholinergic enzyme, and 26.10–82.17 μM against α‐glycosidase as a hydrolytic enzyme. On the other hand, they demonstrated Ki values between 1.25±0.22–25.36±4.72 μM against AChE, and 25.07±4.57–78.55±17.04 μM against α‐glycosidase enzymes. The synthesized nitrogen‐based novel heterocyclic compounds exhibited effective inhibition profiles against both indicated metabolic enzymes. These results may contribute to the development of new drugs particularly to treat some disorders, which widespread display in the world including Alzheimer's disease and diabetes. Furthermore, molecular docking calculations were made to compare the theoretical biological activities of nitrogen‐based novel heterocyclic compounds against proteins including enzymes. After these calculations, ADME/T analysis was performed to examine the drug properties of nitrogen‐based novel heterocyclic compounds.
Structural Modification Engineering of Si Nanoparticles by MIL‐125 for High‐performance Lithium‐ion Storage
Authors: Zhang Huanhuan , Liu Yu , Zhao Jie , Peng Xianhao , Ren Yufan , Wei Xijun , Song Yingze , Cao Zhiqin , Wan Qi 
Published: May 2022

AbstractSi‐based anode electrodes stand out for its excellent capacity among the numerous anode electrodes for lithium‐ion batteries. However, there is still a problem that the volume expansion from the alloying reaction of Li and Si often leads to structural collapse and rapidly capacity degradation. Here, Si nanoparticles (Si NPs) are coated via metal‐organic frameworks (MOFs) derived skeleton to buffer its volume expansion, thereby improving electrochemical properties. Scanning electron microscopy was applied to revealed morphology and structure of the composite material. The results demonstrate that the structure of the prepared composite is Si NPs encapsulated in the unique carbon skeleton. The as‐prepared Si@MIL‐125‐500 exhibits excellent electrochemical performances with an excellent reversible capacity of 304.3 mAh g−1 at 5 A g−1 even after 400 cycles. In addition, the initial coulombic efficiency (ICE) reached up to 86 %. The improved electrochemical performance could be attributed to the distinctive structure of the carbon coated Si NPs and stable titanium(IV) center site, which has improved the electrical conductivity and cycling stability of Si NPs. Moreover, the empty space inside the MOF's carbon skeleton can release the volume strain of Si during electrochemical process. There is an improvement of electrochemical properties for LIBs due to Si NPs restricted in MIL‐125.
Tailoring the d‐Band Centers of Perovskite Oxides for Electrochemical Ozone Production
Authors: Zheng Haiyang , Gao Yijing , Wang Xiaosa , Shi Huaijie , Gu Yu , Jiang Wenbin , Liu Jia , Li Suiqin , Li Aiyuan , Wang Shibin , Wang Jianguo , Zhong Xing 
Published: May 2022

AbstractOzone is one of the most powerful oxidants for disinfection and sterilization. Water electrolysis represents an attractive method for electrochemical ozone production (EOP). Looking for highly active and cost‐effective alternative electrocatalysts to replace toxic PbO2 on the anode of the EOP electrolyzer is important. Here, a series of scalable, low‐toxicity ABO3 perovskite electrocatalysts was successfully synthesized, and their EOP performances were evaluated on the basis of their d‐band center values. Experimental results show that the gaseous ozone output of PrCoO3 is almost 1.3 times higher compared with that of commercial β‐PbO2. Theoretical calculations indicate that the volcanic‐type EOP performance of ABO3 can be attributed to the d‐band center of Co modified by lanthanide elements. Moreover, PrCoO3 demonstrates a remarkable performance in the electrodegradation of various organic pesticides and antibiotics, revealing potential application in advanced oxidation processes.
Synthesis, Structure, and Theoretical Study of Trifluoromethyl Derivatives of the IPR Isomer of C84 Fullerene, C84(11)(CF3)10,12,14
Authors: Tamm Nadezhda B. , Fritz Maria A. , Romanova Natalia A. , Goryunkov Alexey A. , Troyanov Sergey I. 
Published: May 2022

AbstractC84 is the most abundant higher fullerene which is present in the arc‐discharge fullerene soot. Among 24 topologically possible Isolated‐Pentagon Rule isomers of C84, two major isomers, C84(22) and C84(23), and several minor ones have been identified experimentally. We report the synthesis, HPLC isolation, and synchrotron X‐ray structure elucidation of trifluoromethyl derivatives of the most abundant minor isomer of C84, C84(11)(CF3)10,12,14. The experimentally determined addition patterns are discussed in terms of the attachments in ribbons of edge‐sharing para C6(CF3)2 hexagons and the uniform distribution of CF3 groups on the C2‐C84(11) carbon cage. A general scheme of C84(11) trifluoromethylation pathways was proposed on the basis of theoretical DFT calculations of formation energies. Thus, trifluoromethylation pathways are now discussed in details for five different isomers of C84.
Single‐Step Synthesis of Exfoliated Ti3C2Tx MXene through NaBF4/HCl Etching as Electrode Material for Asymmetric Supercapacitor
Authors: Ghosh Meena , Szunerits Sabine , Cao Ning , Kurungot Sreekumar , Boukherroub Rabah 
Published: May 2022

AbstractTwo‐dimensional Ti3C2Tx MXene, derived from the parent Ti3AlC2 phase, is considered a promising electrode material for electrochemical energy storage applications. Ti3C2Tx MXene synthesis methods often employ concentrated hydrofluoric acid (HF), which is harsh, corrosive, and hazardous to the environment. Herein, we report the preparation of Ti3C2Tx MXene following a new synthetic route under a mild reaction condition comprising an aqueous solution of NaBF4 and HCl. This etching environment at a moderate temperature of 130 °C effectively removes the Al layer of the Ti3AlC2 precursor, assisted by the in situ formed HF in the reaction medium. Electron microscopy images of the as‐prepared Ti3C2Tx (MX‐130) reveal a partially exfoliated nanosheet‐like morphology. The material displays a specific capacitance of 262 F g−1 (three‐electrode assembly, 1 A g−1, −0.85 to −0.25 V vs. Hg/Hg2SO4) in 1 M H2SO4 electrolyte. The achieved specific capacitance is superior to that of Ti3C2Tx prepared via the common HF‐treatment (25 F g−1). Additionally, the potential application of the optimized MXene as a negative electrode material is demonstrated in a quasi‐solid‐state RuO2|MX‐130 asymmetric supercapacitor device.