bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland
Authors: Pallonen Terhi Aino-Sofia , Lempiäinen Salla Maria Matleena , Joutsiniemi Titta Kristiina , Aaltonen Riitta Irmeli , Pohjola Pia Erika , Kankuri-Tammilehto Minna Kristiina 
Published: April 2022

AbstractWe have analyzed the histopathological, clinical, and genetic characteristics in hereditary breast and ovarian cancer patients of counselled families from 1996 up to today in the southwestern Finland population. In this study we analyzed the incidence of different BRCA1 and BRCA2 pathogenic variants (PV). 1211 families were evaluated, and the families were classified as 38 BRCA1 families, 48 BRCA2 families, 689 non-BRCA families and 436 other counselled families (criteria for genetic testing was not met). In those families, the study consisted of 44 BRCA1 breast and/or ovarian cancer patients, 58 BRCA2 cancer patients, 602 non-BRCA patients and 328 other counselled patients. Breast cancer mean onset was 4.6 years earlier in BRCA1 carriers compared to BRCA2 (p = 0.07, a trend) and ovarian cancer onset almost 11 years earlier in BRCA1 families (p < 0.05). In BRCA families the onset of ovarian cancer was later than 40 years, and BRCA2-origin breast cancer was seen as late as 78 years. The BRCA PV (9%) increases the risk for same patient having both ovarian and breast cancer with a twofold risk when compared to non-BRCA group (4%) (95% CI p < 0.05). Triple-negativity in BRCA1 (42%) carriers is approximately 2.6 times vs more common than in BRCA2 carriers (16%) (p < 0.05). The risk ratio for bilateral breast cancer is approximately four times when compared BRCA2 (17%) and other counselled patients’ group (4%) (p < 0.05). 27% southwestern BRCA2-families have a unique PV, and correspondingly 39% of BRCA1-families. The results of this analysis allow improved prediction of cancer risk in high-risk hereditary breast and ovarian families in southwestern Finland and improve long term follow-up programs. According to the result it could be justified to have the discussion about prophylactic salpingo-oophorectomy by the age of 40 years. The possibility of late breast cancer onset in BRCA2 carriers supports the lifelong follow-up in BRCA carriers. Cancer onset is similar between BRCA2 carries and non-BRCA high-risk families. This study evaluated mutation profile of BRCA in southwestern Finland. In this study genotype–phenotype correlation was not found
Unveiling OASIS family as a key player in hypoxia–ischemia cases induced by cocaine using generative adversarial networks
Authors: Lee Kyoungmin , Kim Taehyeong , Cheon Mookyung , Yu Wookyung 
Published: April 2022

AbstractRepeated cocaine use poses many serious health risks to users. One of the risks is hypoxia and ischemia (HI). To restore the biological system against HI, complex biological mechanisms operate at the gene level. Despite the complexity of biological mechanisms, there are common denominator genes that play pivotal roles in various defense systems. Among these genes, the cAMP response element-binding (Creb) protein contributes not only to various aspects of drug-seeking behavior and drug reward, but also to protective mechanisms. However, it is still unclear which Creb members are key players in the protection of cocaine-induced HI conditions. Herein, using one of the state-of-the-art deep learning methods, the generative adversarial network, we revealed that the OASIS family, one of the Creb family, is a key player in various defense mechanisms such as angiogenesis and unfolded protein response against the HI state by unveiling hidden mRNA expression profiles. Furthermore, we identified mysterious kinases in the OASIS family and are able to explain why the prefrontal cortex and hippocampus are vulnerable to HI at the genetic level.
Emerging population of gap-opening planets around type-A stars
Authors: Müller-Horn J. , Pichierri G. , Bitsch B. 
Published: April 2022

Context. The presence of forming planets embedded in their protoplanetary disks has been inferred from the detection of multiring structures in such disks. Most of these suspected planets are undetectable by direct imaging observations at current measurement sensitivities. Inward migration and accretion might make these putative planets accessible to the Doppler method, but the actual extent of growth and orbital evolution remains unconstrained.
Aims. Under the premise that the gaps in the disk around HD 163296 originate from new-born planets, we investigate if and under which circumstances the gap-opening planets could represent progenitors of the exoplanet population detected around A-type stars. In particular, we study the dependence of final planetary masses and orbital parameters on the viscosity of the disk.
Methods. The evolution of the embedded planets was simulated throughout the disk lifetime and up to 100 Myr after the dispersal of the disk, taking the evolving disk structure and a likely range of disk lifetimes into account. We modeled the temperature and density structure of the disk based on observational results following the widely used α disk prescription and we varied planetary and disk parameters within the available observational constraints.
Results. We find that the final configuration of the planets is largely determined by the α viscosity parameter of the disk and less dependent on the choice for the disk lifetime and the initial planetary parameters. If we assume that planets such as those in HD 163296 evolve to form the observed exoplanet population of A-type stars, a α parameter on the order of 3.16 × 10−4 ≲ α ≲ 10−3 is required for the disks to induce sufficiently high migration rates. Depending on whether or not future direct imaging surveys will uncover a larger number of planets with mpl ≲ 3 MJup and apl ≳ 10 AU, we expect the α parameter to be at the lower or upper end of this range, always under the assumption that such disks indeed harbor wide orbit planets.
Ces femmes devant nous
Authors: Pirone Ilaria 
Published: April 2022

Suite à la prise du pouvoir des talibans en Afghanistan (août 2021), les coordinateurs du dossier ont décidé de publier un texte qui avait été prononcé par Ilaria Pirone en ouverture d’une journée d’étude sur le trajet des femmes de l’exil (juin 2021). La presse relate comment le nouveau régime essaye d’effacer la voix des femmes, les rendre invisibles, les effacer.
À la différence des héroïnes grecques qui meurent en silence, les femmes de l’exil qui décident un jour de partir et de tout quitter ont trouvé la force de renverser leur destin social. Le travail consiste alors à trouver avec elle comment décider d’exister autrement après ce « non » qu’elles ont réussi à acter. Ce texte est un témoignage de ce que la rencontre avec ces femmes nous enseignent.
Prise en charge des mineurs étrangers non accompagnés : impasses cliniques, politiques, éducatives et institutionnelles
Authors: Giannica Davide , Inticher Binkowski Gabriel 
Published: April 2022

Le travail avec les enfants et les adolescents issus de la migration oblige les professionnels à se confronter aux tensions qui émergent de la rencontre des différences culturelles. On peut ici, en tant que psychanalystes, les considérer comme des modulations des affiliations symboliques dans le contemporain.
La situation clinique traitée par les auteurs de l’article révèle les impasses cliniques, éducatives et politiques dans les dispositifs d’accueil de mineurs étrangers non accompagnés en France. La question du retour au pays d’origine semble bouleverser les soignants, les éducateurs et les institutions, marquant l’apparition de l’archaïque, de fantasmes, de mécanismes de défense et de passages à l’acte institutionnels.
Management der Ohrmuschelteilamputationen
Authors: Huseynov Jamal , Haxel Boris , Fischer Miloš , Fischer Iris-Susanne 
Published: April 2022

ZusammenfassungOhrmuschelverletzungen zählen zu den selteneren Traumata im Kopf-Hals-Bereich. Aufgrund der komplexen Anatomie des Knorpels und der begrenzten Blutversorgung bedürfen sie einer raschen und strukturierten Behandlung. Für die Behandlung sowohl von leichten Verletzungen als auch von (sub-)totalen Abrissen der Ohrmuschel stehen unterschiedliche Therapieoptionen zur Verfügung. Eine direkte Readaptation einer (sub-)total abgerissenen Ohrmuschel ohne mikrovaskulare Anastomose ist aufgrund des hohen Risikos von Haut- und Knorpelnekrosen nur selten erfolgreich. Mehrzeitige Rekonstruktionen mit Pocket-Methoden sind dagegen gut etabliert. Die vorliegende Arbeit beschreibt einige dieser Ansätze und demonstriert eine 2-stufige OP-Technik eines Ohrmuschelteilabrisses aus dem eigenen Patientengut.
Efficacy of aggressive hydration with normal saline versus lactated Ringer’s solution for the prevention of post-ERCP pancreatitis in high-risk patients: a randomized controlled trial
Authors: Patel Rupal , Bertran-Rodriguez Carlos , Kumar Ambuj , Brady Patrick , Gomez-Esquivel Rene , Changela Kinesh , Niknam Negar , Taunk Pushpak 
Published: April 2022

Abstract
Background and study aims Post-ERCP pancreatitis (PEP) is a common adverse event in high-risk patients. Current intervention known to reduce the incidence and severity of PEP include pancreatic duct stent placement, nonsteroidal anti-inflammatory drugs per rectum, and intravenous (IV) fluids. We compared aggressive normal saline (NS) vs aggressive lactated Ringer’s (LR) infusion for the prevention of PEP in high-risk patients undergoing ERCP.
Patients and methods Patients were randomized to receive either an aggressive infusion of NS or LR. The infusion was started at a rate of 3 mL/kg/hr and continued throughout the ERCP procedure. A 20 mL/kg bolus was given at the end of the procedure, then continued at a rate of 3 mL/kg/hr.
Results A total of 136 patients were included in our analysis. The incidence of PEP was 4 % (3/72 patients) in the LR group versus 11 % (7/64 patients) in the NS group resulting in a relative risk (RR) of 0.38 (95 % confidence interval [CI] 0.10 to 1.42; P = 0.19). The relative risk reduction (RRR) was 0.62 (95 % CI –0.41 to 0.90) along with an absolute risk reduction (ARR) of 0.07 (95 % CI –0.025 to 0.17) and an number needed to treat of 15 (95 % CI –41 to 6).
Conclusions To our knowledge, this is the first study comparing aggressive IV NS to aggressive IV LR in high-risk patients. The incidence of PEP was lower in the group receiving an aggressive LR infusion (4 %) compared to NS infusion (11 %). However, the difference was not statistically significant likely due to poor accrual thereby impacting the power of the study.
Role of Serum Carcinoembryonic Antigen in Predicting Recurrent Disease following Curative Resection of Rectal Cancer
Authors: Soma Srikanth , Gurnule Sachin 
Published: April 2022

Introduction Surveillance of patients following definitive treatment of rectal malignancy is based on the predicament that early detection of recurrence may provide an opportunity for cure. Available methods for monitoring include clinical, radiological, and serum tests. The purpose of this study was to determine the effectiveness of CEA in detecting recurrences.
Materials and Methods Retrospective analysis of patients with adenocarcinoma rectum treated with curative intent between 2012 to 2020 at our institute was performed. Postoperatively, patients were followed with CEA measurements according to our institution protocol and elevation of serum CEA above 5 ng/dL was considered as suspicious of recurrence.
Results One hundred ninety patients who received curative treatment were deemed eligible for the analysis. Among these 61 patients had recurrences during the follow-up period and postoperative CEA measurements at the time of recurrence were analyzed in all the patients. Sensitivity, specificity, positive predictive value, and negative predictive value of postoperative CEA to detect recurrences are 81.9, 92.2, 83.3, and 91.5%, respectively.
Conclusion CEA surveillance following definitive management of rectal cancer detects recurrences in majority of the patients and hence strongly recommended.
To Anticoagulate or Not to Anticoagulate in COVID-19: Lessons after 2 Years
Authors: Rizk John G. , Gupta Aashish , Lazo Jose G. , Sardar Partha , Henry Brandon Michael , Lavie Carl J. , Effron Mark B. 
Published: April 2022

AbstractA hypercoagulable state associated with coronavirus disease 2019 (COVID-19) has been well documented and is believed to be strongly supported by a proinflammatory state. The hypercoagulable state in turn results in increased incidence of arterial and venous thromboembolism (VTE) seen in hospitalized COVID-19 when compared with hospitalized non-COVID-19 patient cohorts. Moreover, patients with arterial or VTE and COVID-19 have higher mortality compared with COVID-19 patients without arterial or VTE. Prevention of arterial or VTE thus remains an essential question in the management of COVID-19 patients, especially because of high rates of reported microvascular and macrovascular thrombosis. This has prompted multiple randomized control trials (RCTs) evaluating different anticoagulation strategies in COVID-19 patients at various stages of the disease. Herein, we review findings from RCTs in the past 2 years of antithrombotic therapy in critically ill hospitalized patients, noncritically ill hospitalized patients, patients postdischarge from the hospital, and outpatients. RCTs in critically ill patients demonstrated therapeutic dose anticoagulation does not improve outcomes and has more bleeding than prophylaxis dose anticoagulant in these patients. Trials in noncritically ill hospitalized patients showed a therapeutic dose anticoagulation with a heparin formulation might improve clinical outcomes. Anticoagulation with a direct oral anticoagulant posthospital discharge may improve outcomes, although there is a large RCT in progress. Nonhospitalized COVID-19 patients have an insufficient burden of events to be candidates for antithrombotic therapy. Anticoagulation in pregnant and lactating patients with COVID-19, as well as antiplatelet therapy for COVID-19, is also reviewed.
Integrate the integrators! A call for establishing academic careers for integration experts
Authors: Hoffmann Sabine , Deutsch Lisa , Klein Julie Thompson , O’Rourke Michael 
Published: April 2022

AbstractIntegration is often considered the core challenge and the defining characteristic of inter- and trans-disciplinary (ITD) research. Given its importance, it is surprising that the current system of higher education does not provide permanent positions for integration experts; i.e., experts who lead, administer, manage, monitor, assess, accompany, and/or advise others on integration within ITD projects or programs. Based on empirical results of an ITD 2019 Conference Workshop entitled “Is there a new profession of integration experts on the rise?” held in Gothenburg, Sweden, and our own experience in leading and studying ITD integration, the present article sheds light on the overarching question, “What are integration experts?”, thus contributing to the emerging literature on integration and integration expertise. We use direct quotes from participants to substantiate workshop results and triangulate them with recent literature on ITD research as well as Science of Team Science (SciTS) and Science and Technology Studies (STS). We conclude our article by discussing possible unintended consequences of establishing academic careers for integration experts, and suggest four complementary ways to support them, while mitigating potentially negative consequences: (a) establishing an international Community of Practice (CoP) to foster peer-to-peer exchange among integration experts, create greater visibility, and develop ideas for transforming academic structures; (b) studying academic careers of integration experts to provide empirical evidence of “successful” examples and disclose different ways of establishing related academic positions; (c) funding respective positions and aligning metrics for ITD research to foster integration within ITD projects or programs; and (d) engaging in collaborative dialog with academic institutions and funding agencies to present empirical results and lessons learnt from (a) and (b) to support them in establishing and legitimating careers for integration experts. If academia is to be serious about addressing the most pressing environmental and societal problems of our time, it needs to integrate its integrators.
Evaluating Nebraska’s local comprehensive plans to achieve the national wetland conservation missions in the USA
Authors: Zhang Ligang , Hu Qiao , Hayes Michael , Burbach Mark , Messer Tiffany , Zhou Yuzhen , Tang Zhenghong 
Published: April 2022

ABSTRACT
The U.S. federal government’s requirements and guidance for wetland conservation are reflected in a series of federal laws, regulations, and policies. However, the degree to which these requirements are reflected in local planning efforts is unclear. This study using five components with 56 indicators evaluates how well wetland conservation efforts are integrated into 112 local comprehensive plans in Nebraska, USA. The results show that the majority of local comprehensive plans pay little direct attention to wetland conservation, although many conservation efforts are conducted under the umbrella of environmental protection frameworks. The indicators include water resource protection received the highest score and was the descriptor of natural or environmental resources and resulted in the highest level of local awareness on natural assets. The indicator of setting goals for no net loss of wetlands received the lowest score among all indicators, demonstrating a clear gap between the national vision and the local reality of wetland conservation. Findings suggest local governments need more direct and proactive inputs to improve wetland conservation. Further findings from this research provide a practical roadmap for planners globally, particularly for the developing countries, to integrate wetland conservation into the local planning systems.
Passivation efficacy study of Al2O3 dielectric on self-catalyzed molecular beam epitaxially grown GaAs1-x
Sb
x
nanowires
Authors: Parakh Mehul , Ramaswamy Priyanka , Devkota Shisir , Kuchoor Hirandeep , Dawkins Kendall , Iyer Shanthi 
Published: April 2022

Abstract
This work evaluates the passivation efficacy of thermal atomic layer deposited (ALD) Al2O3 dielectric layer on self-catalyzed GaAs1-x
Sb
x
nanowires (NWs) grown using molecular beam epitaxy. A detailed assessment of surface chemical composition and optical properties of Al2O3 passivated NWs with and without prior sulfur treatment were studied and compared to as-grown samples using x-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and low-temperature photoluminescence (PL) spectroscopy. The XPS measurements reveal that prior sulfur treatment followed by Al2O3 ALD deposition abates III–V native oxides from the NW surface. However, the degradation in 4K-PL intensity by an order of magnitude observed for NWs with Al2O3 shell layer compared to the as-grown NWs, irrespective of prior sulfur treatment, suggests the formation of defect states at the NW/dielectric interface contributing to non-radiative recombination centers. This is corroborated by the Raman spectral broadening of LO and TO Raman modes, increased background scattering, and redshift observed for Al2O3 deposited NWs relative to the as-grown. Thus, our work seems to indicate the unsuitability of ALD deposited Al2O3 as a passivation layer for GaAsSb NWs.
Two-dimensional attractors of A-flows and fibred links on three-manifolds
Authors: Medvedev V , Zhuzhoma E 
Published: April 2022

Abstract
Let f

t
be a flow satisfying Smale’s Axiom A (in short, A-flow) on a closed orientable three-manifold M
3, and Ω a two-dimensional basic set of f

t
. First, we prove that Ω is either an expanding attractor or contracting repeller. Next, one considers an A-flow f

t
with a two-dimensional non-mixing attractor Λ
a
. We construct a casing M(Λ
a
) of Λ
a
that is a special compactification of the basin of Λ
a
by a collection of circles L(Λ
a
) = {l
1, …, l

k
} such that M(Λ
a
) is a closed three-manifold and L(Λ
a
) is a fibre link in M(Λ
a
). In addition, f

t
is extended on M(Λ
a
) to a nonsingular structurally stable flow with the non-wandering set consisting of the attractor Λ
a
and the repelling periodic trajectories l
1, …, l

k
. We show that if a closed orientable three-manifold M
3 has a fibred link L = {l
1, …, l

k
} then M
3 admits an A-flow f

t
with the non-wandering set containing a two-dimensional non-mixing attractor and the repelling isolated periodic trajectories l
1, …, l

k
. This allows us to prove that any closed orientable n-manifold, n ⩾ 3, admits an A-flow with a two-dimensional attractor. We prove that the pair

M

(

Λ

a

)

;
L

(

Λ

a

)

consisting of the casing M(Λ
a
) and the corresponding fibre link L(Λ
a
) is an invariant of conjugacy of the restriction

f

t

|

W

s

(

Λ

a

)

of the flow f

t
on the basin of the attractor Λ
a
.
Exponential stability estimate for the derivative nonlinear Schrödinger equation*
Authors: Cong Hongzi , Mi Lufang , Wu Xiaoqing , Zhang Qidi 
Published: April 2022

Abstract
In this paper, we prove an exponential long time stability result for the derivative nonlinear Schödinger equation (DNLS) in some Sobolev space by using Birkhoff normal form technique and some suitable nonresonant conditions.
Geometric estimates for doubly nonlinear parabolic PDEs
Authors: Bezerra Júnior Elzon C , da Silva João Vitor , Ricarte Gleydson C 
Published: April 2022

Abstract
In this manuscript, we establish

C

loc

α
,

α

θ

regularity estimates for bounded weak solutions of a certain class of doubly degenerate evolution PDEs, whose simplest model case is given by

∂
u

∂
t

−
d
i
v

(

m
|
u

|

m
−
1

|
∇
u

|

p
−
2

∇
u

)

=
f

(

x
,
t

)

in

Ω

T

≔
Ω
×

(

0
,
T

)

,

where m ⩾ 1, p ⩾ 2 and f belongs to a suitable anisotropic Lebesgue space. Employing intrinsic scaling techniques and geometric tangential methods, we derive sharp regularity estimates for such models, which depend only on universal and compatibility parameters of the problem. In this scenario, our results are natural improvements for former ones in the context of nonlinear evolution PDEs with degenerate structure via a unified approach. As a consequence of our findings and approach, we address a Liouville type result for entire weak solutions of a related homogeneous problem with frozen coefficients and asymptotic estimates under a certain approximating regime, which may have their own mathematical interest. We also present examples of degenerate PDEs where our results can be applied.
Single-photon blockade in quasichiral atom–photon interaction: simultaneous high purity and high efficiency
Authors: Lu Yu-Wei , Liu Jing-Feng , Li Runhua , Wu Yanxiong , Tan Haishu , Li Yongyao 
Published: April 2022

Abstract
We investigate the single-photon blockade (1PB) in the quasichiral regime of atom–photon interaction, where the effective coupling between the cavity and the atom is bidirectional but asymmetrical, achieved by coupling to a dissipative environment. A synthetic magnetic current ϕ is induced in the closed-loop coupling, which breaks down the reciprocity of atom–photon interaction, and can be utilized to create asymmetrical or even unidirectional effective coupling between two selected quantum states. As an example, we couple the single-atom cavity quantum electrodynamics (QED) system to a strongly dissipative plasmonic cavity. We find that in the quasichiral regime, the unconventional photon blockade (UPB) and the conventional photon blockade (CPB) realize simultaneously in the condition of maximum chirality (ϕ = π/2 and 3π/2). As a result, 1PB in the quasichiral regime can combine the advantages of both UPB and CPB, demonstrating the perfect single-photon purity, higher efficiency, non-oscillating time dynamics as well as lower requirement of mode coupling to achieve UPB. Our work paves the way for 1PB towards practical applications and reveals the intriguing quantum-optics phenomena in the quasichiral light–matter interaction.