bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertriglyceridemia May be a Key Independent Predicting Factor for Gallbladder Cancer Risk in Gallbladder Stone Disease Patients: A Case-Control Study
Authors: Wan Yong , Zhang Jianqin , Chen Min , Ma Mao , Sheng Binwu 
Published: March 2022

Abstract
Background Gallbladder stone diseases (GSD) is a main risk factor of gallbladder cancer (GBC). This study aimed to reveal their bridge relating to metabolic syndrome. Material/Method We summarized the clinical and experimental data of 2210 GBC patients, from 3524 Chinese patients, in our hospital from Jan. 2009 to Dec. 2020. The metabolic syndrome indexes, influencing factors for both GBC and GSD, were analyzed by unconditional logistic regression in this case-control study. Result There were significant higher morbidity of GBC in the overall, GSD and non-GSD with hypertriglyceridemia patients versus non-hypertriglyceridemia ones (P<0.001, all). In GSD patients, univariate regression showed significantly positive correlation between serum triglyceride, low density lipoprotein cholesterol (LDL-c), fasting insulin (FINS) levels, Homeostasis model assessment-insulin resistance (HOMA-IR), female being, body mass index, hypertriglyceridemia and hazard of GBC with GSD (P<0.001, all), while significantly negative correlation to systolic pressure (SBP), diastolic pressure (DBP), hypertension and high-density lipoprotein cholesterol (HDL-c), fasting blood glucose (FBG) (P<0.05, all); multivariate regression showed that serum triglyceride, was the most significantly positive associated to GBC (P<0.001, all) among the hazard factors including serum triglyceride, LDL-c levels, HOMA-IR, female being. In non-GSD ones, multivariate regression showed that HOMA-IR was the most significantly positive associated to GBC among the hazard factors including serum TG, LDL-c levels, HOMA-IR, female being, hypertriglyceridemia, while DM had a significantly inversion negative association (P<0.001). Conclusion We found initially that hypertriglyceridemia could be the remarkable independent predicting factor of GBC risk with GSD, while insulin resistance might act as the first one in non-GSD. Thus, we advocated initially the sharp rise of serum TG levels as the potential of a candidate diagnostic or prognostic biomarker of GBC with GSD.
Venous Thromboembolism in COVID-19 Patients and Prediction Model: A Multicenter Cohort Study
Authors: Lee Yi , Jehangir Qasim , Li Pin , Gudimella Deepthi , Mahale Pooja , Lin Chun-hui , Apala Dinesh R. , Krishnamoorthy Geetha , Halabi Abdul Rahman , Patel Kiritkumar , Poisson Laila , Balijepally Venugopal , Sule Anupam A , Nair Girish B. 
Published: March 2022

Abstract
Background Patients with COVID-19 infection are commonly reported to have an increased risk of venous thrombosis. The choice of anti-thrombotic agents and doses in COVID-19 patients are currently being studied in randomized controlled trials and retrospective studies. There exists a need for individualized risk stratification of venous thromboembolism (VTE) to assist clinicians in decision-making on anticoagulation. We sought to identify the risk factors of VTE in COVID-19 patients, which could help physicians in prevention, early identification and management of VTE in hospitalized COVID-19 patients and improve clinical outcomes in these patients. Methods This is a multicenter, retrospective database of four main health systems in southeast Michigan, United States. We compiled comprehensive data for adult COVID-19 patients who were admitted between 1st March 2020 and 31st December 2020. Four models including random forest, multiple logistic regression, multiple linear regression, and decision trees were built on the primary outcome of in-hospital acute deep vein thrombosis and pulmonary embolism and tested for performance. The study also reported hospital length of stay (LOS) and intensive care unit (ICU) LOS in the VTE and the non-VTE patients. Four models were assessed using area under the receiver operating characteristic curve and confusion matrix.Results The cohort included 3531 admissions, 3526 had discharge diagnosis, and 6.68% patients developed acute VTE (N=236). VTE group had a longer hospital and ICU LOS than non-VTE group (hospital LOS 12.2 days vs 8.8 days, p<0.001; ICU LOS 3.8 days vs 1.9 days, p<0.001). 9.8% patients in VTE group required more advanced oxygen support, compared to 2.7% patients in non-VTE group (p<0.001). Among all four models, the random forest model had the best performance. The model suggested that blood pressure, electrolytes, renal function, hepatic enzymes and inflammatory markers were predictors of in-hospital VTE in COVID-19 patients. Conclusions and Relevance Patients with COVID-19 have increased risk for VTE, and patients who developed VTE had a prolonged hospital and ICU stay. This random forest prediction model for VTE in COVID-19 patients identifies predictors which could aid physicians in making clinical judgment on empirical dosages of anticoagulation.
Video Observed Treatment is an Innovative Method of Tuberculosis Treatment Observation in Resource-Limited Health Care Settings
Authors: Pavlyuchenkova N. A. , Vasilyeva I. A. , Samoylova A. G. , Tyulkova T. E. 
Published: March 2022

The objective of the study: to analyze the potential use of video observed therapy (VOT) as one of the fields of mobile health care for treatment of patients with tuberculosis, to substantiate prospects of using VOT as an alternative to directly observed therapy including settings with limited health care resources.Subjects and Methods. The relevant studies were searched for in the following bibliographic databases: MEDLINE/PubMed, EMBASE, LILACS, IMEMR and IMSEAR, and clinicaltrials.gov. 40 publications devoted to video observed treatment of tuberculosis abroad and in Russia were selected. The recommendations of the World Health Organization on the use of digital technology in tuberculosis treatment, in particular video observed treatment have been studied.Results. The article highlights the advantages of video observed treatment of tuberculosis, the possibility of implementing this approach in different groups of patients taking into account the inclusion and exclusion criteria, assessing effectiveness of its use (improved treatment adherence, higher number of completed observations, better responsibility of patients for the disease and therapy, economic benefits for the health system and the patient). The study speculates on the potential implementation of video observed therapy of tuberculosis in the Russian Federation.
Radiotherapy and Breast Reconstruction: What Is the Ideal Timing?
A Narrative Review
Authors: Letsiou Evanthia , Tsakatikas Sergios , Vakis George , Tsapakidis Konstantinos , Charalampakis Nikolaos , Diamantis Alexandros , Poultsidi Antigoni , Michelakis Dimosthenis , de Bree Eelco , Mauri Davide , Tsoukalas Nikolaos , Antoniades Chrysostomos , Tolia Maria 
Published: March 2022

Introduction:
Women undergoing mastectomy choose to pursue breast reconstruction (BR) in order to reduce their body image distress.Adjuvant chest wall irradiation is associated with a negative cosmetic outcome. The aim of our review was to identify the optimal timing of BR relating to radiotherapy delivery.

Materials and Methods:
Using Cochrane Library, Embase, PubMed, Springer, Wanfang and CNKI, we performed a non-systematic review of articles published up to August 2021.

Result:
There is no hard evidence in favor of immediate, delayed or 2-stage BR when post-mastec-tomy radiation is indicated. Immediate and 2-stage BR seem to be valid alternatives to delayed BR.

Conclusion:
Further research is essential in order to assess clinician and patient reported aesthetic outcomes and determine the optimal timing of BR in view of post-mastectomy radiotherapy, in breast cancer survivors.
IMPACT OF COVID-19 PANDEMIC IN THE SUPPLY CHAIN MANAGEMENT OF THE MILK TEA STORES
Authors: De Jesus Fhrizz Saet , Buenaventura Blisa Pacada 
Published: March 2022

Purpose â€” This paper assesses the impact of the Covid- 19 Pandemic in the supply chain management (SCM) of the milk tea stores in Bongabon, Nueva Ecija, Philippines. Since milk tea is a popular drink in the said area, this paper seeks to know how the owners deal with the barriers they have encountered during the pandemic. Â Design/methodology/approach â€” The study used a descriptive method using a total enumeration as the sampling technique.Â The respondents were fully operational milk tea store owners who encountered barriers in their SCM.Findings â€” In line with the barriers in the SCM, the study shows that the majority of the respondents strongly agreed that the staff is afraid of the spread of the virus (Human Resource), experienced Limited business time of operation (Enforcement of Local Rules), Limited entrants of delivery vehicle (Transportation), Instability in the supply of raw materials (Raw Materials), & Sales decrease due to pandemic (Cash flow).Practical Implications â€” The business operations of the respondents suffered from the effect of the covid 19 pandemics.Originality/value â€” This study presents the recommendation on how the business owners can cope up with the impact of this pandemic not only in their SCM but their business as a whole.Keywords Covid- 19 Pandemic, Supply Chain Management, Milk tea.Paper Type Research Paper.
THE INFLUENCE OF PERCEIVED USEFULNESS AND PERCEIVED EASE OF USE ON INTENTION TO USE GOJEK APPLICATION AND ITS IMPACT ON PURCHASE DECISION OF GOJEK SERVICES
Authors: Hutagalung Ulianto , Sukriah Yani , Ritonga Nursakinah 
Published: March 2022

Purpose â€” The purpose of this reseacrh is to explain and analyze the influence of Perceived UsefulnessÂ and Perceived Ease of Use on Intention to Use the Gojek application and its impact on Gojek service purchasing decisions.Design/methodology/approach â€” This study uses a quantitative approach using explanatory research. The population of this study is The citizen of Padangsidimpuan City, North Sumatera who use Gojek Services at least five times a month. To determine the sample of the population, researchers used Machin & Champbell (1987)Â formula to obtain the number of respondents as many as 115 people. The sampling technique of this study is the nonprobability sampling technique. The method of data collection used a questionnaire distributed to the respondent and calculated using a Likert scale. Data analysis methods consist of test instruments, research requirements testing, and hypothesis testing with path analysis by SPSS.Findings â€” The results of this study indicate that the Perceived Usefulness and Perceived Ease of Use has a positive and significant effect on the Intention to use Gojek application.Â Practical Implications â€” Perceived Usefulness and Intention to Use Gojek application has a positive and significant influence on purchasing decisions, while the Perceived Ease of Use has no significant influence on Purchasing Decisions.Keywords Perceived Usefulness, Perceived Ease of Use,Â Intention to Use, Purchase Decision, GojekPaper Type Research Paper.
REGULATION HEGEMONY AND ACCOUNTABILITY OF THE LOCAL GOVERNMENT: A STUDY ON REGIONAL FINANCIAL MANAGEMENT IN INDONESIA
Authors: Witono Banu , * Nurkholis , * Roekhudin 
Published: March 2022

AbstractObjectives - The purpose of this study is to uncover the reality of implementing regional financial management regulations and their impact on local government accountability.Research method approach - This study uses a critical qualitative research approach to the Gramsci hegemony perspective. This approach is useful for analyzing the shackles of regulation in the implementation of regional financial management.Findings - The results show that regulation has become a means for the state to dominate in the realm of political society and hegemony for civil society. This results in an orientation of local government accountability which tends to vertical accountability rather than horizontal (public) accountability .Practical implications -Â Changes in regional autonomy regulations have led to increasing dominance of the central government to the regions. This is reflected in the various regulations produced by the institutions in the central government which shackle the space and innovation of the local government in managing regional finances.Social implications - Due to the shackles of the regulation, local governments prioritize serving the interests of the central government (vertical accountability) compared to services to the society (horizontal accountability).Originality / Value - This study contributes to uncovering the facts that occur related to regional financial management, so that it can provide input to the government in the implementation of regional government accountability.Keywords: Regional Government Accountability, Regional Financial Management Regulations, Regulation Hegemony.Paper Type: Research Paper
Pembelajaran pengenalan tumbuhan melalui Cooperative Script pada peserta didik Kelas IV di SDN 37 Sui Ambawang Kabupaten Kuburaya
Authors: Afidah Siti 
Published: March 2022

Tujuan penelitian ini adalah untuk meningkatkan pengenalan tumbuhan melalui Cooperative Script pada peserta didik Kelas IV di SDN 37 Sui Ambawang, Kabupaten Kuburaya yang awalnya peserta didik belum bisa mengenal dengan berbagai nama karakteristik tumbuhan. Melalui Cooperative Script maka setiap peserta didik diharapkan mampu mengulang dan memahami nama-nama tumbuhan secara mudah. Metode penelitian ini menggunakan penelitian tindakan kelas (PTK). Subyek dalam penelitian ini adalah siswa Kelas IV di Sekolah Dasar 37 Sui Ambawang yang berjumlah 15 siswa. Pada saat pembelajaran di lakukan keadaan pseserta didik masih di rasa kurang pemahaman peningkatan pengetahuan di mana pada saat pra siklus dari 15 peserta didik baru lulus 3 peserta didik dengan persentasi 20%, di lanjutkan ke siklus 1 lulus 11 peserta didik didik dengan persentasi 73% dan di lanjutkan siklus II dengan perbaikan perencanaan dan pelaksaan yang akurat, tepat dan penuh kemandirian yang mendukung dan upaya yang besar baru bisa di katakan lulus 15 peserta didik dengan persentasi 100%, dengan adanya model Cooperative Script pembelajaran peserta didik lebih mudah diterima karena terjadi pengelompokan dan kemandirian secara merata dan akuntabel meberdayakan kelompok yang lebih kecil dan efektif.
POHON TEORI EVALUASI KEBIJAKAN DAN PROGRAM (Metode, Nilai dan Menilai, Penggunaan)
Authors: Hajaroh Mami 
Published: March 2022

Tulisan ini mendeskripsikan filosofi keilmuan evaluasi kebijakan dan program. Evaluasi sebagai bagian dari proses kebijakan merupakan tahap penting, yakni sebagai tahap penyediaan informasi tentang kebijakan dan program yang berjalan. Dalam prakteknya, evaluasi memerlukan teori-teori evaluasi. Teori yang dimaksudkan oleh para theorist identik dengan pendekatan atau model teori yang bersifat preskriptif, bukan tentang teori deskriptif atau empiris. Pohon teori evaluasi sebagai ilmu terapan dibangun oleh tiga akar ilmu yakni epistemology, social inqury dan social accountability yang membangun tiga cabang ilmu evaluasi. Ketiga cabang ilmu evaluasi meliputi cabang metode (method), cabang menilai (valuing), dan cabang penggunaan (use). Ketiga cabang pohon ilmu evaluasi dilihat sebagai sesuatu yang saling berhubungan satu sama lain. Bila pohon ilmu evaluasi itu berada dalam ruang tiga dimensi maka ujung kanan adalah cabang penilaian akan berhubungan dengan sisi paling kiri yakni cabang penggunaan. Para ahli ilmu evaluasi ditempatkan pada setiap cabang dengan melihat kecenderungan utama dan khusus dari pendekatan ilmu yang mereka kembangkan. Kata Kunci: Evaluasi, Pohon Teori, Pendekatan Evaluasi, Evaluasi Kebijakan
PEMBELAJARAN REMEDIAL SEBAGAI SUATU UPAYA DALAM MENGATASI KESULITAN BELAJAR
Authors: Lidi Maria Waldetrudis 
Published: March 2022

Artikel ini merupakan telaah pustaka tentang pembelajaran remedial sebagai upaya untuk mengatasi kesulitan belajar. Berdasarkan temuan awal, sebagian besar tenaga pengajar di Universitas Flores belum melaksanakan pembelajaran remedial dan belum memahami prinsip-prinsip dan prosedur pembelajaran remedial. Oleh karena itu penulis merasa penting untuk melakukan kajian tentang pembelajaran remedial pada tahap akhir kegiatan pembelajaran. Hasil kajian yang diperoleh tentang pembelajaran remedial adalah pengertian dan karakteristik, tujuan, prinsip, tipe pengajaran remedial, prosedur dan waktu pelaksanaan remedial. Penelitian ini memberikan saran operasional bagaimana memperbaiki dan mengatasi kesulitan belajar. Kata Kunci: Pembelajaran Remedial, Kesulitan Belajar
PEMANFAATAN DANA PROGRAM INDONESIA PINTAR (PIP) OLEH SISWA SMPN 2 GEDANGSARI KABUPATEN GUNUNGKIDUL
Authors: Sholikhah Ebni 
Published: March 2022

Program Indonesia Pintar (PIP) merupakan program pemberian dana kepada siswa dari keluarga kurang mampu. Program ini menyaratkan bahwa dana harus dimanfaatkan untuk keperluan personal siswa sehingga anak terlepas dari ancaman putus sekolah. Meskipun ada PIP, ternyata putus sekolah masih terjadi di Kecamatan Gedangsari. Penelitian ini bertujuan untuk melihat pemanfaatan dana PIP oleh siswa jenjang SMP di Kecamatan Gendangsari khususnya SMPN 2 yang memiliki siswa putus sekolah tertinggi. Penelitian menggunakan pendekatan kualitatif dengan metode studi kasus. Hasilnya menunjukkan bahwa sekolah melakukan diskresi dalam pengelolaan dana. Dana telah digunakan untuk pembiayaan personal siswa, meskipun masih ada item yang tidak seharusnya dibiayai dana tersebut. Dilihat dari besaran dana, PIP baru mampu mengover pembiayaan personal siswa sebesar 55-58%. Jika melihat kondisi ekonomi masyarakat yang mayoritas masuk kategori miskin, maka diperlukan inisiatif pihak sekolah untuk merancang usaha dana secara mandiri atau kerjasama dengan sektor swasta untuk turut terlibat dalam pembiayaan pendidikan. Kata Kunci: Program Indonesia Pintar (PIP), Pendanaan Pendidikan, SMP
TRANSFORMASI NILAI-NILAI INTI BUDAYA DALAM PERBAIKAN SEKOLAH
Authors: Siswoyo Dwi , Sukardi Joko Sri , Efianingrum Ariefa 
Published: March 2022

Kegiatan PPM ini bertujuan untuk menggelorakan spirit perbaikan dan peningkatan mutu sekolah. Upaya tersebut memerlukan berbagai pendekatan, baik struktural maupun kultural. Pendekatan kultural memusatkan perhatian pada kesadaran dan komitmen warga sekolah tentang pentingnya nilai-nilai. Nilai-nilai inti budaya sekolah bersumber dari sekolah dan disepakati bersama oleh warga sekolah. Nilai-nilai tersebut perlu ditransformasikan untuk menginspirasi warga sekolah dalam peningkatan prestasi dan kinerja. Metode kegiatan adalah pelatihan dengan sasaran kepala sekolah, guru, dan perwakilan orang tua siswa di dua sekolah dasar di wilayah Kecamatan Ngaglik, Kabupaten Sleman. Hasil kegiatan menunjukkan bahwa transformasi dapat dilakukan setelah nilai-nilai inti budaya sekolah digali dan disepakati bersama. Sekolah perlu mengidentifikasi keunggulan, potensi, tantangan, dan hambatan dalam upaya perbaikan sekolah. Hasilnya menjadi pertimbangan dalam menentukan solusi terhadap problem kontekstual di sekolah. Upaya perbaikan sekolah memerlukan pelibatan orang tua siswa dan kemitraan dengan institusi lain dalam seluruh tahapan proses kebijakan. Mulai dari perancangan, perumusan, implementasi, dan evaluasi program yang mendukung upaya perbaikan sekolah. Kata Kunci: transformasi, nilai budaya, sekolah dasar
Contributions of Artificial Intelligence Reported in Obstetrics and Gynecology Journals: Systematic Review
Authors: Dhombres Ferdinand , Bonnard Jules , Bailly Kévin , Maurice Paul , Papageorghiou Aris T , Jouannic Jean-Marie 
Published: March 2022

Background
The applications of artificial intelligence (AI) processes have grown significantly in all medical disciplines during the last decades. Two main types of AI have been applied in medicine: symbolic AI (eg, knowledge base and ontologies) and nonsymbolic AI (eg, machine learning and artificial neural networks). Consequently, AI has also been applied across most obstetrics and gynecology (OB/GYN) domains, including general obstetrics, gynecology surgery, fetal ultrasound, and assisted reproductive medicine, among others.

Objective
The aim of this study was to provide a systematic review to establish the actual contributions of AI reported in OB/GYN discipline journals.

Methods
The PubMed database was searched for citations indexed with “artificial intelligence” and at least one of the following medical subject heading (MeSH) terms between January 1, 2000, and April 30, 2020: “obstetrics”; “gynecology”; “reproductive techniques, assisted”; or “pregnancy.” All publications in OB/GYN core disciplines journals were considered. The selection of journals was based on disciplines defined in Web of Science. The publications were excluded if no AI process was used in the study. Review, editorial, and commentary articles were also excluded. The study analysis comprised (1) classification of publications into OB/GYN domains, (2) description of AI methods, (3) description of AI algorithms, (4) description of data sets, (5) description of AI contributions, and (6) description of the validation of the AI process.

Results
The PubMed search retrieved 579 citations and 66 publications met the selection criteria. All OB/GYN subdomains were covered: obstetrics (41%, 27/66), gynecology (3%, 2/66), assisted reproductive medicine (33%, 22/66), early pregnancy (2%, 1/66), and fetal medicine (21%, 14/66). Both machine learning methods (39/66) and knowledge base methods (25/66) were represented. Machine learning used imaging, numerical, and clinical data sets. Knowledge base methods used mostly omics data sets. The actual contributions of AI were method/algorithm development (53%, 35/66), hypothesis generation (42%, 28/66), or software development (3%, 2/66). Validation was performed on one data set (86%, 57/66) and no external validation was reported. We observed a general rising trend in publications related to AI in OB/GYN over the last two decades. Most of these publications (82%, 54/66) remain out of the scope of the usual OB/GYN journals.

Conclusions
In OB/GYN discipline journals, mostly preliminary work (eg, proof-of-concept algorithm or method) in AI applied to this discipline is reported and clinical validation remains an unmet prerequisite. Improvement driven by new AI research guidelines is expected. However, these guidelines are covering only a part of AI approaches (nonsymbolic) reported in this review; hence, updates need to be considered.