bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Umbilical Hernia repair in male patients with abdominal obesity
Authors: AlMulhim Abdulrahman Saleh , Memon Abdul Qadeer 
Published: August 2022

Objective: Obesity is a global health problem, and obese patients are subject to developing abdominal wall hernias. There are few prospective studies comparing the laparoscopic method of umbilical hernia mesh repair between abdominal obesity patients and normal abdominal waist patients. The aim of this study was to evaluate the short-term outcomes (operative time, early complications and hospital stay) in the patients having laparoscopic hernia repair with abdominal obesity.
Methods: This prospective cohort study was conducted at King Fahad Hospital Hofuf, Kingdom of Saudi Arabia from June 2014 to June 2021. Fifty four (54) adult male patients with umbilical hernia were included in this study. The patients were divided into two groups: Group-A: Patients with abdominal obesity (n=26), and Group-B: Patients without abdominal obesity (n=28). All the patients underwent laparoscopic repair of umbilical hernia. The patients with abdominal obesity were defined as those having an abdominal girth more than 102 centimeters.
Results: No significant differences were observed as related to age, co-morbidity and risk factors between the two groups. The statistically significant difference between the two groups observed was related to the mean operative time and the mean hospital stay.
Conclusion: Laparoscopic umbilical hernia repair can be safely performed in abdominal obesity in male patients without an additional risk of complications.
doi: https://doi.org/10.12669/pjms.38.7.6470
How to cite this:Al-Mulhim AS, Memon AQ. Laparoscopic Umbilical Hernia repair in male patients with abdominal obesity. Pak J Med Sci. 2022;38(7):1776-1779. doi: https://doi.org/10.12669/pjms.38.7.6470
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review of the literature on the dangers of zolpidem use, its potential for abuse and addiction
Authors: Skowrońska Katarzyna , Chmura Anna , Pondel Kamil , Cyboran Katarzyna , Baciur Patrycja 
Published: August 2022

Introduction and purpose of the work : Commonly Z-drugs, especially zolpidem , are considered safer than short-acting drugs benzodiazepines . Recently, more and more is said about the abuse of these relatively harmless drugs. The aim of this study is to collect scientific reports on the increasing abuse of these drugs.
State of knowledge: There are many reports of zolpidem abusers and addicts in the available literature . These people belong to three groups of patients: the first is people with insomnia who develop tolerance, the second is recreational use, and the third is people with mental disorders. Taking increased doses of zolpidem causes a psychostimulant effect, increased activity during sleep, up to delusions and psychotic symptoms. Rapid discontinuation of high doses of the drug should be performed in a hospital setting. Summary : Physicians should be advised to remain vigilant during therapy with group Z drugs and to check that the patient is not receiving the drug from multiple sources and is not taking zolpidem in supra-therapeutic doses .
Economic and Environmental Implications of Biomass Commercialization in Agricultural Processing
Authors: Li Bin , Boyabatlı Onur , Avcı Buket 
Published: August 2022

Motivated by the agricultural industries, this paper studies the economic and environmental implications of biomass commercialization; that is, converting organic waste into a saleable product from the perspective of a processor that uses a commodity input to produce both a commodity output and biomass. We characterize the economic value of biomass commercialization and examine how input and output spot price uncertainties affect this value. Using a model calibration, we find that lower input spot price variability or higher output spot price variability or correlation between the two spot prices increases this value for a typical palm oil mill. To measure the environmental impact, we use total expected carbon emissions resulting from profit-maximizing decisions and characterize the change in total expected emissions after commercialization. Our analysis reveals that, although higher biomass demand or biomass price always increases the value of biomass commercialization, these changes are not necessarily environmentally beneficial as they may increase the emissions associated with biomass commercialization. We also characterize conditions under which biomass commercialization is environmentally beneficial or harmful; that is, it leads to a reduction or an increase in the total expected emissions, respectively. In comparison with the existing understanding which does not take into account optimization of operational decisions, our analysis highlights two types of misconceptions (and characterizes the specific conditions under which they appear): (i) we would mistakenly think that biomass commercialization is environmentally beneficial when it is not, and (ii) we would mistakenly think that biomass commercialization is environmentally harmful when it is not. This paper was accepted by Victor Martínez-de-Albéniz, operations management. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4518 .
The experiences of physiotherapists and occupational therapists working as rehabilitation ward leaders
Authors: Locke Rachel , Wilkinson Emma , Wallis Lucy , Kibble Sharon , Harden Beverley 
Published: August 2022

Background/Aims Rehabilitation teams have piloted the deployment of physiotherapists and occupational therapists into the role of ward leader. This was the first research study designed specifically to explore the experiences of physiotherapists and occupational therapists working as ward leaders on wards with a patient rehabilitation focus and how to optimise this workforce transformation. Methods An interpretivist qualitative study was designed to enable the detailed exploration of physiotherapists' and occupational therapists' working experiences during their time as ward leaders. A total of 11 physiotherapists and occupational therapists with between 6 months' and 3 years' experience of working as ward leaders participated in semi-structured interviews. Thematic analysis was undertaken. Results Four themes were derived from the data analysis that related to participants' experiences: becoming a rehabilitation ward leader; responsibilities of physiotherapists and occupational therapists; perceptions of the role; and impact of allied health professionals in ward leader roles. Although taking on the role of a rehabilitation ward leader was reported as ‘challenging’, participants would recommend it. Success was perceived by interviewees to be relative to the presence of personal leadership qualities, the belief of the individual in their unique skill set and the confidence in the leadership team to value the unique and shared skills of the profession or individual and thus reinvent the role. Conclusions This study identifies the key attributes that evidence the unique contribution that physiotherapists and occupational therapists working as rehabilitation ward leaders can make. The findings of this study are significant and highly relevant for the ongoing pandemic, which has seen a need for increased rehabilitation capability.
The impact of e-scooter injuries
Authors: Singh Priya , Jami Meghana , Geller Joseph , Granger Caroline , Geaney Lauren , Aiyer Amiethab 
Published: August 2022

Aims Due to the recent rapid expansion of scooter sharing companies, there has been a dramatic increase in the number of electric scooter (e-scooter) injuries. Our purpose was to conduct a systematic review to characterize the demographic characteristics, most common injuries, and management of patients injured from electric scooters. Methods We searched PubMed, EMBASE, Scopus, and Web of Science databases using variations of the term “electric scooter”. We excluded studies conducted prior to 2015, studies with a population of less than 50, case reports, and studies not focused on electric scooters. Data were analyzed using t-tests and p-values < 0.05 were considered significant. Results We studied 5,705 patients from 34 studies. The mean age was 33.3 years (SD 3.5), and 58.3% (n = 3,325) were male. The leading mechanism of injury was falling (n = 3,595, 74.4%). Injured patients were more likely to not wear a helmet (n = 2,114; 68.1%; p < 0.001). The most common type of injury incurred was bony injuries (n = 2,761, 39.2%), of which upper limb fractures dominated (n = 1,236, 44.8%). Head and neck injuries composed 22.2% (n = 1,565) of the reported injuries, including traumatic brain injuries (n = 455; 2.5%), lacerations/abrasions/contusions (n = 500; 7.1%), intracerebral brain haemorrhages (n = 131; 1.9%), and concussions (n = 255; 3.2%). Standard radiographs comprised most images (n = 2,153; 57.7%). Most patients were treated and released without admission (n = 2,895; 54.5%), and 17.2% (n = 911) of injured patients required surgery. Qualitative analyses of the cost of injury revealed that any intoxication was associated with higher billing costs. Conclusion The leading injuries from e-scooters are upper limb fractures. Falling was the leading mechanism of injury, and most patients did not wear a helmet. Future research should focus on injury characterization, treatment, and cost. Cite this article: Bone Jt Open 2022;3(9):674–683.
Investigating New Patterns in Symptoms of COVID-19 Patients by Association Rule Mining (ARM)
Authors: Singh Anju , Singh Divakar , Upreti Kamal , Sharma Vaibhav , Rathore Bhawani Singh , Raikwal Jagdish 
Published: August 2022

Background: COVID-19 is a major public health emergency wreaking havoc on public health, happiness, and liberty of travel, as well as the worldwide economy. Scientists from all over the world are working to develop treatments and vaccines; the WHO has given emergency approval to eight vaccines from around the world. However, it is also seen that the efficiency of vaccines is not up to the mark in different age groups. COVID-19 symptoms come in many different shapes and sizes, so it’s important to learn about them as soon as possible so that medical attention and management can be easier.
Method: The GitHub Data Repository-made COVID-19 patient data is available on the internet, which is used in this investigation. We have used the association rule mining method to look for common patterns in a targeted class or segment and then look at the symptoms based on them.
Result: The result is that this study involves individuals with a median age of 52 years old. Few frequent symptoms like respiratory failure (1%), septic shock (1.4%), respiratory distress syndrome (1.8%), diarrhoea (1.8%), nausea (2%), sputum (3%), headache (5%), sore throat (8%), pneumonia (8%), weakness (7%), malaise/body pain (11%), cough (37%), fever (67%) and remaining diseases like myocardial infarction, cardiac failure, and renal illness (less than 1%) were present. If a patient had chronic disease, respiratory failure, and pneumonia, there was a higher risk of death; if a patient had a combination of chronic disease, respiratory failure, and pneumonia, respiratory failure in the age range of 45 to 84 years there was a higher risk of death. Patients having chronic conditions like pneumonia or renal disease symptoms that died as a result of the corona virus had more serious indication patterns than those without chronic diseases.
Trimester-specific phthalate exposures in pregnancy are associated with circulating metabolites in children
Authors: Goodrich Jaclyn M. , Tang Lu , Carmona Yanelli R. , Meijer Jennifer L. , Perng Wei , Watkins Deborah J. , Meeker John D. , Mercado-García Adriana , Cantoral Alejandra , Song Peter X. , Téllez-Rojo Martha M. , Peterson Karen E. 
Published: August 2022

Background
Prenatal phthalates exposures have been related to adiposity in peripuberty in a sex-specific fashion. Untargeted metabolomics analysis to assess circulating metabolites offers the potential to characterize biochemical pathways by which early life exposures influence the development of cardiometabolic risk during childhood and adolescence, prior to becoming evident in clinical markers.

Methods
Among mother-child dyads from the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) birth cohort, we measured 9 phthalate metabolites and bisphenol A in maternal spot urine samples obtained during each trimester of pregnancy, corrected for urinary specific gravity and natural log-transformed. In 110 boys and 124 girls aged 8–14 years, we used a mass-spectrometry based untargeted metabolomics platform to measure fasting serum metabolites, yielding 572 annotated metabolites. We estimated the associations between trimester-specific urinary toxicants and each serum metabolite, among all children or stratified by sex and adjusting for child age, BMI z-score, and pubertal onset. We accounted for multiple comparisons using a 10% false discovery rate (q<0.1).

Results
Associations between exposures and metabolites were observed among all children and in sex-stratified analyses (q<0.1). First trimester MEP, MiBP, and MCPP were associated with decreased 2-deoxy-D-glucose among all children. Among girls, third trimester concentrations of MECPP, MEHHP, MEHP, and MCPP were associated with 15, 13, 1, and 10 metabolites, respectively, including decreased choline and increased acylcarnitines and saturated FAs (FA). Among boys, third trimester MIBP was positively associated with 9 features including long chain saturated FAs, and second trimester MBzP was inversely associated with thyroxine.

Conclusions
Metabolomics biomarkers may reflect sex- and exposure timing-specific responses to prenatal phthalate exposures manifesting in childhood that may not be detected using standard clinical markers of cardiometabolic risk.
Antibiotics and probiotics on hepatic venous pressure gradient in cirrhosis: A systematic review and a meta-analysis
Authors: Zhang Haonan , Gao Jian 
Published: August 2022

Background
Modulation of the gut microbiome could favorably alter the hepatic venous pressure gradient (HVPG) in cirrhosis and portal hypertension (PH).

Aim
This meta-analysis was to evaluate the effects of microbiome-targeted therapies (MTTs) on HVPG in persons with cirrhosis and PH.

Methods
PubMed, The Cochrane Library, Embase, Web of Science and Scopus were searched for randomized clinical trials (RCTs) analyzing the effects on HVPG in people with cirrhosis who received MTTs. Clinical outcomes were pooled using RevMan5.3 software. A trial sequential analysis was applied to calculate the required information size and evaluate the credibility of the meta-analysis results.

Results
A total of six studies were included. MTTs were associated with a reduction of 1.22 mm Hg in HVPG (95% CI: -2.31, -0.14 mmHg, P = 0.03). Subgroup analysis showed a greater reduction with longer duration (-1.88 mmHg;95% CI: -3.23, -0.53; P = 0.006). In the trial sequential analysis of HVPG reduction, the cumulative Z curve crossed the traditional significance boundary without the achievement of required information size (330).

Conclusions
MTTs may be associated with a reduction in HVPG in patients with cirrhosis and PH. Microbiome-targeted therapies merit additional large-sample studies to define the efficacy of HVPG.

Systematic review registration
PROSPERO 2020: CRD4202021609.
A multivariate analysis to propose linear models for the stature estimation in the Sabahan young adult population
Authors: Khazri Hasanur Bin , Shimmi Sadia Choudhury , Parash M. Tanveer Hossain 
Published: August 2022

BackgroundStature is one of the significant parameters to confirm a biological profile besides sex, age, and ancestry. Sabah is in the Eastern part of Malaysia and is populated by multi-ethnic groups. To date, limited studies on stature estimation have been conducted in Sabah. Hence, this study aims to construct population-specific stature estimation equations for the large ethnic groups in Sabah, Malaysia.ObjectiveThe aim is to propose linear models using different hand dimensions (hand span, handbreadth, hand length, middle finger length, and the second inter-crease in the middle finger) for the young adult male and females of the major ethnic groups in Sabah.Materials & methodsThis cross-sectional study framework used stratified random sampling on 184 male and 184 female young adults. An unpaired t-test and a one-way ANOVA were used to assess the differences in the mean between sex and ethnicities, respectively. The link between the response variable and explanatory variables was initially investigated using simple linear regression, followed by multiple linear regression.ResultThe present study demonstrated the highest association for the quantitative explanatory variables among hand length and stature (right side: r = 0.833; left side: r = 0.842). Simple equations were specifically developed without sex indicators, and ethnic and multiple linear regression was developed with sex and ethnic indicators. Multiple linear regression provided good estimation r2= 0.7886 and adjusted r2= 0.7853. The stature of 18 to 25 year old large ethnic groups in Sabah can be estimated using the developed models 90.218 + 3.845 LHL -5.950 Sex—2.308 Bajau -1.673 KadazanDusun + 2.676 L2ICL. While, formula for each ethnic and sex KadazanDusun Male: Stature = 88.545 + 3.845 LHL+ 2.676 L2ICL, KadazanDusun Female: Stature = 82.595 + 3.845 LHL+ 2.676 L2ICL, Bajau Male: Stature = 87.910 + 3.845 LHL+ 2.676 L2ICL, Bajau Female: Stature = 81.960 + 3.845 LHL+ 2.676 L2ICL, Malay Male: Stature = 90.218 + 3.845 LHL+ 2.676 L2ICL, Malay Female: Stature = 84.268 + 3.845 LHL+ 2.676 L2ICL, Chinese Male: Stature = 90.218 + 3.845 LHL+ 2.676 L2ICL, and Chinese Female: Stature = 84.268 + 3.845 LHL+ 2.676 L2ICL.ConclusionThe study reports anthropometric data and formulas for measuring the stature of major ethnic groups in Sabah, which can be used to compare future work.
The existence of solutions for the modified
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Authors: Figueiredo Giovany , Vetro Calogero 
Published: August 2022

We consider the Dirichlet problem

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driven by the sum of a
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strong generalized solution), using the properties of pseudomonotone operators.
A novel variant in RUNX1 in a patient with refractory eosinophilic gastrointestinal disease and long-term clinical response to ketotifen
Authors: Scott Ori , Garkaby Jenny , Abrego Fuentes Laura , Roifman Chaim M. , Willett Pachul Jessica 
Published: August 2022

Background: Eosinophilic gastrointestinal disease (EGID) is an umbrella term for a heterogeneous group of disorders affecting the GI tract. In contrast to the relatively common eosinophilic esophagitis (EoE), eosinophilic gastroenteritis (EGE) remains poorly understood in terms of both its pathophysiology and genetic etiology, while treatment options remain limited. Aim: To expand the genotypic spectrum of EGE and describe our long-term experience of treatment with ketotifen. Methods: Case report of a patient with EGE followed by our team for over 27 years. Results: Our patient was diagnosed with EGE at the age of 4 years, accompanied by multiple other atopic manifestations and serum eosinophilia. He was later diagnosed with a heterozygous variant in RUNX1, a gene implicated in multi-lineage hematopoiesis, inhibition of Th2 polarization and T regulatory cell function. The patient has experienced long-term symptom improvement while treated with the mast cell stabilizing H1 antihistamine, ketotifen, with substantial symptomatic worsening after this agent was briefly stopped. Conclusion: We expand the genotypic spectrum of EGID etiology to include mutations in RUNX1, and suggest ketotifen as a viable option for patients with treatment-refractory EGE. Statement of novelty: This case reports on a possible novel genetic cause of EGID and describes long-term successful clinical management with ketotifen.
Association between NOD2 and autoinflammation presenting as Yellow Nail Syndrome
Authors: Abrego Fuentes Laura Edith , Alsalamah Mohammad 
Published: August 2022

Background: Yellow Nail Syndrome is defined as a triad of lymphedema, respiratory symptoms, and nail discolouration. The precise etiology remains unknown, however it has been reported alongside a broad spectrum of conditions including malignancies, autoinflammatory diseases, and immunodeficiencies. Aim: To highlight the association between defects in the intracellular bacterial sensor gene NOD2 and Yellow Nail Syndrome. Methods: A retrospective review of the patient’s chart was performed, including family history, characteristics, immune laboratory evaluation, and genetics. Results: A 65-year-old female was referred to our centre for lymphedema and bronchiectasis. She had recurrent episodes of pneumonia, cellulitis, and oral ulcers. Bilateral lymphedema on her lower limbs up to the hip and discoloured yellow nails were reported. Given her clinical picture, she was diagnosed with Yellow Nail Syndrome. The immunological evaluation was unremarkable overall, with normal T cell subsets and function and adequate antibody titers. Genetic testing identified a heterozygous mutation in the NOD2 gene, c.2107C>T (p.Arg703Cys), considered a variant of uncertain significance. Conclusion: Heterozygous variants in NOD2 can result in a spectrum of autoimmune and autoinflammatory disorders, including Yellow Nail Syndrome. Statement of novelty: We describe a patient with Yellow Nail Syndrome, presenting with the classic triad of clinical features. Genetic evaluation identified a heterozygous variant in NOD2, which has been extensively associated with several autoinflammatory diseases, but not Yellow Nail Syndrome.