bluuebunny/crossref_metadata_2025_split huggingface dataset:
Update of intensity-duration-frequency (IDF) curves under climate change: a review
Authors: Kourtis Ioannis M. , Tsihrintzis Vassilios A. 
Published: March 2022

AbstractLand use and land cover changes, population growth, urban sprawl and climate change are expected to augment the pressure on natural environment and on existing infrastructure. As a result, update of intensity-duration-frequency (IDF) curves considering climate change is essential for adaptation of water-related structures to climate change. The present work reviews the main challenges regarding the update of IDF curves considering climate change. A wide literature search was conducted in scientific databases. More than 100 articles published between 2001 and 2021 have been reviewed and are summarized and discussed. The main aims of the present work were to: (i) identify the state-of-the-art scientific approaches regarding IDF curve update under climate change projections; (ii) assess whether or not these approaches incorporate uncertainty (i.e., uncertainty related to climate models, statistical downscaling techniques, temporal resolution of data, theoretical distribution selection etc.); and (iii) propose general guidelines for updating IDF curves based on climate projections. First, the motivation is presented that makes IDF curve renewal a global issue. Second, current practices are described and reviewed and the main impacts of climate change on short precipitation extremes around the world are briefly discussed. Finally, limitations and future research needs are discussed.
Investigation of effective parameters on brackish water desalination by flow-electrode capacitive deionization
Authors: Dehghan Khadijeh , Mirbagheri Seyed Ahmad , Alam Mahdi 
Published: March 2022

Abstract
Population growth and increasing global demand for freshwater have raised a serious challenge for the depleting sources of freshwater in the 21st century. Desalination technologies can be a reliable technique for providing freshwater. Capacitive deionization is one of the innovative desalination methods that has received increasing interest. Flow-electrode capacitive deionization (FCDI) (a new architecture of capacitive deionization) is one of the efficient, cost-effective, and environmentally friendly desalination methods for freshwater production. In this experimental research, the performance of an FCDI system was investigated and the influence of important parameters such as flow rate of flow-electrodes, electrolyte salt concentration of flow-electrodes, and initial feed water concentration will be assessed on the efficiency of desalination operation. In this study, the flow-electrodes operated in short-circuited closed-cycle operation (SCC) mode, and also the feed water operated similarly to the flow electrodes in closed cycle. Moreover, in all the experiments, the salt adsorption capacity (SAC) and salt removal efficiency (SRE) was calculated. Herein, by optimizing the above-mentioned parameters, the salt removal efficiency of 83% and a SAC value of 29.12 mg/gdry carbon were achieved in 5 hours.
The Emerging Role of EMT-related lncRNAs in Therapy Resistance
and their Applications as Biomarkers
Authors: kichi Zahra Abedi , Soltani Mona , Rezaei Mina , Shirvani-Farsani Zeinab , Rojhannezhad Mahbubeh 
Published: March 2022

Abstract:
Cancer is the world's second-largest cause of death. The most common cancer
treatments are surgery, radiation therapy, and chemotherapy. Drug resistance, epithelial--
to-mesenchymal transition (EMT), and metastasis are pressing issues in cancer therapy today.
Increasing evidence showed that drug resistance and EMT are co-related with each
other. Indeed, drug-resistant cancer cells possess enhanced EMT and invasive ability. Recent
research has demonstrated that lncRNAs (long non-coding RNAs) are non-coding
transcripts which play an important role in the regulation of EMT, metastasis, and drug
resistance in different cancers. However, the relationships among lncRNAs, EMT, and
drug resistance are still unclear. These effects could be exerted via several signaling pathways,
such as TGF-β, PI3K-AKT, and Wnt/β-catenin. Identifying the crucial regulatory
roles of lncRNAs in these pathways and processes leads to the development of novel targeted
therapies. We review the key aspects of lncRNAs associated with EMT and therapy
resistance. We focus on the crosstalk between lncRNAs and molecular signaling pathways
affecting EMT and drug resistance. Moreover, each of the mentioned lncRNAs
could be used as a potential diagnostic, prognostic, and therapeutic therapy resistancefor
cancer. However, the investigation of lncRNAs for clinical applications still has several
challenges.
Essential Principles and Recent Progress in the Development of TSPO
PET Ligands for Neuroinflammation Imaging
Authors: Viviano Monica , Barresi Elisabetta , Siméon Fabrice G. , Costa Barbara , Taliani Sabrina , Da Settimo Federico , Pike Victor W. , Castellano Sabrina 
Published: March 2022

Abstract:
The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane and is implicated in several functions, including cholesterol transport and stereoidogenesis. Under normal physiological conditions, TSPO is present in very low concentrations in the human brain but is markedly upregulated in response to brain injury and inflammation. This upregulation is strongly associated with activated microglia. Therefore, TSPO is particulary suited for assessing active gliosis associated with brain lesions following injury or disease.
For over three decades, TSPO has been studied as a biomarker. Numerous radioligands for positron emission tomography (PET) that target TSPO have been developed for imaging inflammatory progression in the brain. Although [¹¹C]PK11195, the prototypical first-generation PET radioligand, is still widely used for in vivo studies, mainly now as its single more potent R-enantiomer, it has severe limitations, including low sensitivity and poor amenability to quantification. Second-generation radioligands are characterized by higher TSPO specific signals but suffer from other drawbacks, such as sensitivity to the TSPO single nucleotide polymorphism (SNP) rs6971. Therefore, their applications in human studies have a burden of needing to genotype subjects. Consequently, recent efforts are focused on developing improved radioligands that combine the optimal features of the second-generation with the ability to overcome the differences in binding affinities across the population. This review presents essential principles in the design and development of TSPO PET ligands and discusses prominent examples among the main chemotypes.
Relationship between Gut Microbiota and Bone Health
Authors: Lu Hai , You Ke , Yang Lianjun , Shen Jun , Liu Bin , Guo Yuanqing , Chen Tao , Li Guowei 
Published: March 2022

Abstract:
Gut Microbiota (GM) are microorganisms that live in the host gastrointestinal tract, and their abundance varies throughout the host’s life. With the development of sequencing technology, the role of GM in various diseases has been increasingly elucidated. Unlike earlier studies on orthopedic diseases, this review elucidates the correlation between GM health and bone health and discusses the potential mechanism of GM effects on host metabolism, inflammation, and ability to induce or aggravate some common orthopedic diseases, such as osteoarthritis, osteoporosis, rheumatoid arthritis, etc. Finally, the prospective methods of GM manipulation and evaluation of potential GM-targeting strategies in the diagnosis and treatment of orthopedic diseases are reviewed.
Synthesis, Characterization, Antibiofilm and Anticancer Activity of New
Ruthenium Complexes with 2,2'-bipyridine-4,4'-dicarboxamide
Authors: Kilincarslan Sidika Demet , Sahin Cigdem , Mutlu Dogukan , Nasirli Farid , Arslan Sevki , Dogan Nazime Mercan 
Published: March 2022

Abstract:
New ruthenium complexes bearing bipyridine ligands with different substituents (propyl,
hexyl, isobutyl, and benzyl) were synthesized and characterized by MS, NMR, FTIR, and UV/Visible
spectroscopy. Moreover, their cytotoxic, anti-carcinogenic, and anti-biofilm activities were evaluated.
The electrochemical properties of the complexes have been investigated by cyclic voltammetry. The
HOMO and LUMO energy levels of RuL1-RuL4 were found to be (-5.45 eV)-(-5.46 eV) and (-2.98
eV)-(-3.01 eV), respectively. Cytotoxic activities of ruthenium complexes were investigated in Caco-2,
HepG2, and HEK293 cells. It was found that RuL3 showed a cytotoxic effect on cancer cells without
affecting non-cancerous cells at applied doses. The presence of the benzyl group may increase the
cytotoxic effect of RuL3 compared to other derivatives that contain the alkyl group. The apoptotic effect
of the RuL3 derivative was determined by using Arthur image-based cytometer. It found that RuL3
induced apoptosis in Caco-2 (5-fold) and HepG2 (2-fold) cancer cells, respectively. All ruthenium
complexes inhibited Staphylococcus aureus ATCC 29213 biofilm, but RuL3 had a more pronounced
effect. Moreover, RuL3 had biofilm inhibition and biofilm degradation effect, while RuL1 and RuL4
demonstrated only biofilm inhibition. The fluorescent microscopy analysis confirmed the antibiofilm
effect of ruthenium complexes. All of these results clearly showed that RuL3 showed cytotoxic and
apoptotic effects on cancer cells.
EGFR Inhibitor CL-387785 Suppresses the Progression of Lung
Adenocarcinoma
Authors: Wang Jiying , Cai Yong , Sheng Zhaoying , Dong Zhiyi 
Published: March 2022

Objective:
This study aimed to explore the influence of the irreversible EGFR inhibitor CL-387785 on invasion, metastasis, and radiation sensitization of non-small cell lung cancer cells.

Methods:
The proliferation inhibitory rate at different time points was detected by MTT assay. The apoptosis of H1975 cells treated with CL-387785 was detected using flow cytometry. The invasion and migration of H1975 cells treated with CL-387785 were determined by Transwell assay and wound healing assay. The survival fraction (SF) of H1975 cells cultured with CL-387785 under X-ray (0, 2, 4, 6, 8, and 10 Gy) was detected by cloning formation experiment, and the sensitization ratio (SER) was calculated by clicking the multi-target model to fit the cell survival curve.

Results:
CL-387785 restrained H1975 cell proliferation in a concentration- and time-dependent manner. CL-387785 promoted H1975 cell apoptosis and reduced cell migration distance and the number of transmembrane cells. The SF treated by different concentrations of CL-387785 (10, 25, 50, and 100 nM) was all below 0 nM. The radiation SER of CL-387785 (10, 25, 50 and 100 nM) were 1.17, 1.39, 2.88, and 3.64, respectively.

Conclusion:
The invasion and metastasis of H1975 cells were restrained by irreversible EGFR inhibitor CL-387785. CL-387785 also exhibited the effect of radiotherapy sensitization.
Specifics of Political and Legal Documents on Cooperation between the EAEU and third Countries (part 2)
Authors: Berezina E. K. 
Published: March 2022

This study examines the transregional interaction of the EAEU with third countries within the framework of the concept of “soft power” on the basis of concluded cooperation agreements bearing international legal obligations. Aim. The study aims to identify the features of the bilateral interaction of the EAEU with Vietnam, Singapore, China, Serbia and Iran within the framework of the concept of “soft power” based on a comparative analysis of political and legal documents on cooperation.Tasks. The author defines the conceptual foundations of the economic dimension of “soft power”; considers political and legal documents on cooperation concluded between the EAEU and Vietnam, Singapore, China, Serbia, Iran, and identifies the components of “soft power” on the basis of the concluded documents.Methods. The study uses methods of content analysis and comparative analysis of political and legal documents on cooperation based on criteria such as legal form, institutional mechanism, areas of cooperation to identify the features of bilateral cooperation between the EAEU and Vietnam, Singapore, China, Serbia, Iran and the components of “soft power”.Results. The study shows that the “soft power” components of political and legal documents on cooperation are more presented in the relationship between the EAEU and Vietnam and Singapore. It is the provisions of these agreements that most often mention scientific and technical cooperation and the implementation of joint research projects, scientific and educational exchange, and education issues. Nevertheless, there are risks in the field of integration interaction between the EAEU and the aforementioned countries, due to both the geographical factor and their specifics in building integration relations with third countries.Conclusions. Transregional interaction between the EAEU and the above-mentioned countries is aimed at the exchange of information, liberalization and transparency in trade, support for the mechanisms of the World Trade Organization (WTO). An analysis of political and legal documents on cooperation between the EAEU using the example of Vietnam and Singapore demonstrates the opportunities for the EAEU not only to integrate into the global economy and strengthen competitiveness, but also to increase the attractiveness of the EAEU states in terms of promoting the “soft power” strategy.
The Efficacy and Safety of Baduanjin in Patients with Coronary Heart Disease After Percutaneous Coronary Intervention：A Systematic Review and Meta-analysis
Authors: Li Xing , Dai hua , Tan huan , Zhang ling 
Published: March 2022

Objective: To evaluate the effects of Baduanjin on quality of life
(QOL), psychological status and cardiac function of patients with
coronary heart disease after percutaneous coronary intervention (PCI).
Methods: PubMed, The Cochrance Library, Embase, Web of Science, China
Biology Medicine disc, CNKI, VIP and Wanfang were searched by a computer
for any randomized controlled trials of Baduanjin intervention in
patients with coronary heart disease after PCI, including relevant
conference articles and academic papers published in journals. The
retrieval time was from the database creation time to September 7, 2020.
After two evaluators independently screened the literature, extracted
relevant data and evaluated the bias risk for the included studies,
RevMan5.3 software was used for a data analysis. Results:A total of 9
articles and 846 patients were included. The meta-analysis showed that
the Baduanjin group was superior to the conventional western medicine
treatment group in physical hunctioning、role-physical 、general
health、role-emotional 、mental health、 anxiety、 anxiety、left
ventricular ejection fraction、blood pressure、stroke volume，and the
differences were statistically significant.But the Baduanjin group
was not superior to the control group in bodily pain、vitality、social
functioning,and the differences were not statistically significant.
Conclusion: Baduanjin can improve the cardiac function, regulate the
psychological state and improve the QOL among patients with coronary
heart disease after PCI.
Factors Affecting the Sustainability of Organizational Learning in the Branches of Social Security Lorestan
Authors: Alaeifr Alimohammad , Ghasemi Reza , Imani Hassan 
Published: March 2022

This research aims to study the influencing factors on organizational learning in Social Security organization branches in Lorestan. In this study, individual, motivation for learning, team dynamics and cultural activities considered as independent variables and continuing of organizational learning are considered as a dependent variable. Methodology: The used methodology is descriptive and correlative; these community members are 299 sample size is 141 formal and conventional employees in all branches who are selected randomly according to Cocoran Formula. Data gathering tool is obtained by a questionnaire with 36 items which are separated according to individual motivation for learning, team dynamics, and organization’s activities cultural. Results: Research results using Pearson coefficient and multiple regression indicate that there is a meaningful and direct relationship with 99% confidentiality between (individual motivation for learning, team dynamics, and organization cultural activities) and continuous learning. Conclusion: It means that in the case of increasing individual motivation for learning, team dynamics and cultural activities of the organization; Continuity of learning will be increased. And in result, the organization can take steps forward towards goal better and favorably.
Uncovering Teachers’ Implicit Leadership Theories for School Administrators: A Qualitative Inquiry
Authors: Aypay Ahmet , Kaşarcı İsmail , Dönmez Ayşe , Özdemir Murat 
Published: March 2022

Purpose: This study attempted to expand the existing knowledge regarding school administrators’ effective and ineffective leadership behaviours and traits based on the perceptions of teacher respondents.
Design/Methodology/Approach: The basic interpretive qualitative approach was adopted to scrutinize and discover the cultural attributions of the participating teachers. Research data were collected from 64 teachers working at a metropolitan city centre in mid-western Turkey. The respondents were asked to list the effective and ineffective characteristics of a school leader.
Findings: A total of 379 expressions (249 effective, 130 ineffective) defining leader behaviours and traits were obtained. On average, there were 5.92 (SD: 2.06; min.=2, max.=9) expressions per participating teacher. We found seven effective leader behavioural themes with a total of 38 leader attributes and five ineffective leader behavioural themes with 27 leader attributes.
Implications/Originality/Value: A seven-themed taxonomy of educational leadership behaviours was created. The results implied that communication skills and being an expert in the post are crucial as highlighted both by effective and ineffective leader attributes. The paper was concluded by offering some implications.
Sigale-gale samosir: from the sacred to the secular | Sigale-gale samosir: dari yang sakral menjadi sekular
Authors: Minawati Rosta , Alamo Enrico 
Published: March 2022

Sigale-gale is a life-sized wooden puppet carved in the likeness of a human male. It is used during burial rituals and in modern Sigale-gale dance performances in the Toba Batak community, Samosir, North Sumatra. The traditional myth of sigale-gale has become folklore which depicts the making of a wooden statue in human form given to Raja Rahat who is ill because his favorite son Manggale died in the battle. The sigale-gale is used by the community as well in funeral ceremonies for the dead who have died childless. In contemporary practice sigale-gale has been reconceived as public performance mostly for tourists. The sigale-gale thus now functions differently socially and culturally, moving from the mythological towards the worldly. The sigale-gale dance was originally only accompanied by the music of sordam but mostly now by a mixed ensemble comprised of taganing, gong, and suling. A performance can include five to seven dancers (panortor). Sigale-gale also vary in size from human dimensions as well as smaller or even bigger. Sigale-gale in its new forms represents an effort to sustain the cultural values of the Toba Batak.

Patung sigale-gale terbuat dari kayu yang dipahat menyerupai manusia (laki-laki) digunakan saat ritual pemakaman dan dalam pertunjukan tari sigale-gale baru di masyarakat Batak Toba, Samosir, Sumatera Utara. Mitos keberadaan sigale-gale menjadi folklore yang menceritakan pembuatan patung kayu menyerupai manusia dipersembahkan kepada Raja Rahat yang sakit karena anaknya tewas di medan pertempuran. Sigale-gale digunakan pada upacara kematian yang tidak memiliki keturunan. Dalam perkembangannya, sigale-gale menjadi seni pertunjukan untuk menghibur wisatawan. Fungsi sigale-gale secara sosial budaya menjadi berbeda, yakni dari sakral ke profan. Awalnya sigale-gale hanya diiringi musik Sordam dan Sabangunan, tetapi di masa kini pertunjukan sigale-gale diiringi musik gondang, gong dan suling. Pertunjukan sigale-gale terdapat panortor lima sampai tujuh orang. Ukuran patung sigale-gale bervariasi, ada yang tinggi seukuran manusia ada juga yang memiliki ukuran tubuh lebih kecil ataupun lebih besar. Unsur pertunjukan terdiri dari: Sigale-gale, musik dan tor-tor (tari). Sigale-gale dalam bentuk baru merupakan upaya pelestarian nilai-nilai budaya masyarakat Batak Toba.
IMPLEMENTASI ALGORITMA ADVANCED ENCRYPTION STANDARD (AES) UNTUK KEAMANAN QR-CODE SEBAGAI DIGITAL SIGNATURE PADA APLIKASI E-SURAT
Authors: Wibowo Dhika Maulana Okto , Astuti Erna Dwi , Sibyan Hidayatus 
Published: March 2022

Proses Surat Menyurat pada Fakultas Ekonomi (FE) UNSIQ masih diketik melalui Ms. Word. Banyaknya tahapan yang dilakukan dalam membuat surat menjadikan waktu yang dibutuhkan cukup banyak selain itu keamanan surat juga tidak dapat dijamin. Hal ini akan mengurangi kinerja dan efisiensi pada proses administrasi di Fakultas Ekonomi UNSIQ. Oleh karena itu dibuatlah aplikasi Sistem e-Surat (SERAT) FE UNSIQ yang di dalamnya sudah diimplementasikan Algoritma AES untuk mempercepat kinerja pembuatan surat dan menjamin keasliannya. Implementasi Algoritma AES dimasukkan ke dalam URL pengecekan surat yang dikonversi menjadi QR-Code agar mudah dipindai. Penelitian ini diharapkan dapat membantu proses pembuatan surat di Fakultas Ekonomi UNSIQ dan menjamin keaslian surat yang dibuat.
Identifikasi Faktor – Faktor Kepuasan Pengguna Terhadap Layanan Website Universitas ABC Menggunakan Metode IPA
Authors: Kesuma Dorie Pandora , Ekawati Rika Kharlina 
Published: March 2022

Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor kepuasan pengguna dari layanan website Universitas ABC dengan menggunakan metode Importance Performance Analysis (IPA). Metode IPA digunakan untuk mengukur tingkat kepuasan pengguna dalam menggunakan suatu layanan yang tersedia. Populasi dalam penelitian ini adalah seluruh mahasiswa Universitas ABC dimana jumlah sampel diambil sebanyak 200 responden. Metode penelitian yang digunakan adalah survei dengan kuesioner yang dianalisis dengan IPA (Importance Performance Analysis) untuk mengetahui tingkat kepuasan pengguna yang merupakan gap antara harapan dan persepsi. Hasil penelitian menunjukkan bahwa dari ke 27 atribut yang dianalisis dengan metode IPA dikelompokkan ke dalam kuadran I (7 atribut), kuadran II (8 atribut), kuadran III (5 atribut) dan kuadran IV (6 atribut).