bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trehalose-induced alterations in serum expression levels of microRNAs associated with vascular inflammation in patients with coronary artery disease - the pilot results from the randomized controlled trial.
Authors: Ganjali Shiva , Jamialahmadi Tannaz , Abbasifard Mitra , Emami Seyed Ahmad , Tayarani-Najaran Zahra , E. Butler Alexandra , Banach Maciej , Sahebkar Amirhossein 
Published: September 2022

IntroductionBackground: This study aimed to investigate the trehalose-induced alterations in serum expression levels of miRNAs associated with vascular inflammation in patients with coronary artery disease (CAD) in order to evaluate the effectiveness of intravenous (IV) trehalose administration in reducing arterial wall inflammation.Material and methodsMethods: This trial enrolled 14 men with a history of myocardial infarction (MI) and systemic inflammation. The patients were randomized in a 2:1 ratio to trehalose (15g/week, IV administration) (N=10) or placebo (equal volume 0.9% normal saline) (N=4) for a period of 12-weeks. The relative serum expression levels of miRNA-126, miRNA-24, miRNA-181b, miRNA-10a and miRNA-92a were assessed.ResultsResults: IV trehalose administration significantly increased the serum level of miRNA-24 (2.473±0.72; P=0.037) compared to the baseline, but did not alter the other miRNA serum levels. However, at the end of the study, miRNA-24 (4.58±0.99; P=0.002), miRNA-181b (4.08±1.75; P=0.009) and miRNA-10a (3.68±0.63; P=0.013) showed notably higher serum levels in the trehalose relative to the placebo group. Furthermore, the reduction (normalized to baseline) in serum levels of miRNA-126 (P=0.042) and miRNA-92a (P=0.001) were reduced in the trehalose versus placebo group, while the serum level of miRNA-24 (P=0.007) was notably higher than that in the placebo group.ConclusionsConclusion: Serum levels of miRNAs associated with vascular inflammation were altered following IV trehalose administration. The alterations in serum miRNAs, especially miRNA-126 and miRNA-24, could be considered as helpful biomarkers for the evaluation of trehalose potency in reducing arterial wall inflammation in patients with CAD.
PEMBANGUNAN MINDA REMAJA PERSPEKTIF ‘ULWAN: TINJAUAN TERHADAP AMALAN KELUARGA DI PUTRAJAYA
Authors: IZZAH NUR AIDA BT ZUR RAFFAR  , ZURIANI IBHRIM  , MOHAMMAD FAHMI ABDUL HAMID  
Published: September 2022

Remaja adalah khazanah dan tonggak kekuatan negara. Namun, segelintir remaja Islam kini terperangkap dengan tingkah laku yang tidak baik, budaya pergaulan bebas antara lelaki dan wanita, gaya hidup dan ideologi yang jauh dari agama, serta gejala sosial yang akan membinasakan generasi. Kesilapan dalam cara berfikir dan gaya hidup remaja yang terpesong ini mesti diperbetulkan dengan membangunkan dan memperkukuh nilai intelek mereka sendiri. Oleh itu, kajian ini bertujuan untuk menganalisis kaedah pengamalan keluarga di Putrajaya dalam pembangunan minda anak remaja berteraskan perspektif ‘Ulwan. Reka bentuk kajian ini adalah kajian tinjauan menggunakan alat soal selidik untuk meninjau 384 responden yang dipilih dalam kalangan ibu bapa beragama Islam yang mempunyai remaja di Putrajaya. Data dianalisis menggunakan SPSS dengan teknik statistik deskriptif. Dapatan kajian menunjukkan kebanyakan ibu bapa menghantar anak ke sekolah agama untuk mendalami ilmu agama (min = 3.44), mengenal pasti bakat dan potensi anak (min = 3.44), dan mengenal pasti kecenderungan serta minat anak (min = 3.41). Implikasi daripada kajian ini dapat membantu ibu bapa memantapkan ilmu keibubapaan dan seterusnya dapat diterapkan kepada remaja di rumah. Penyelidikan ini turut menyumbang kepada pihak bertanggungjawab agar lebih progresif menguruskan pembangunan belia dan keluarga di Malaysia.

Adolescents are a valuable asset and pillar of strength for a country. However, a handful of Muslim adolescents now practise behaviour based on lust, free association between men and women, lifestyle and ideology far removed from religion, and social symptoms that would destroy generations. The mistakes in the way of thinking and lifestyle of these wayward young people must be corrected by developing and strengthening their personal intellectual values. This study was aimed at analysing the family practice methods in Putrajaya in terms of adolescent mind development based on the perspective of ‘Ulwan. This study was designed as a survey using a questionnaire instrument with 384 respondents comprised of purposefully selected Muslim parents with adolescents in Putrajaya. Data was analysed with descriptive statistical techniques using SPSS. Findings of the study showed that the majority of parents sent their children to religious school to further their religious knowledge (mean = 3.44), identify the child's talents and potential (mean = 3.44), and ascertain the child's inclinations and interests (mean = 3.41). The implications of this study may help parents strengthen their parenting knowledge and skills, and subsequently inculcate this among the adolescents in the family. This study may also contribute knowledge and understanding to enable those responsible in managing adolescent and family affairs in Malaysia to be more progressive and effective.
Materiality of Homeopathic Medicines. DynHom Research Program.
Authors: Wassenhoven Michel Van , Dorfman Pierre 
Published: September 2022

Background: Homeopathy is controversial because using highly dilute medicines (high homeopathic potencies, HHP) beyond the Avogadro/Loschmidt limit. Previous publications [1,2] using NMR relaxation revealed the involvement of nanobubbles and/or nanoparticles and/or nanometric superstructures in high potentizations. NTA demonstrated the presence of particles in HHPs [3,4]. With SEM-EDX [5] we observed an ionic diversity common to all preparations including HHPs and significant differences in the relative quantity of each ion between different homeopathic manufacturing lines and controls. FTIR spectroscopy [6] shows that the molecular composition is that of carbonates, primarily sodium bicarbonate.
Methods: To observe the materiality of homeopathic medicines a multidisciplinary approach is necessary. In collaboration with several universities we are able to observe these medications with NMR, NTA, SEM-EDX, FTIR, pH and EPA.
Results: The essential component of all already studied homeopathic medicines is sodium hydrogen carbonate modulated by some other elements in specific quantity, size and shape. The probability that the observed results could have occurred just by random chance can be rejected (especially above Avogadro limit) p < 0,001.
Conclusions: The homeopathic medicines do contain material with a specific ionic composition even in HHPs diluted beyond the Avogadro/Loschmidt limit. This specificity can be attributed to the manufacturing process. These results demonstrate that the step-by-step process (dynamized or not) does not match the theoretical expectations in a dilution process. The starting material and dilution/dynamization method influences the nature of these NPs. The role of carbonates and sodium bicarbonate must be carefully studied in the future. Its aqueous solution is alkaline in nature but it is an amphoteric compound, which means that the compound has both acidic as well as alkaline character. The reaction with acids results in sodium salts and carbonic acid and reaction with basic solution produce carbonates and water. Specific electric fields are indeed detectable.
use of speckle laser to identify canopy variations in plants subjected to ultra-high diluted substances
Authors: Zanco Jasper J 
Published: September 2022

The reaction of plants to ultra-high dilute substances (UHD) is well known, however, the signaling of the immediate effect still doesn't have a widely accepted methodology. The objective of this experiment was to use non-destructive sampling to find signs of UHD soon after application to plants. The control consisted of untreated purslane [Pilea microphylla (L.) Liebm] plants and imaged with a digital camera Mobius (CMOS 1270x720 pixels) directed at a laser beam (±680 nm) emitted over the plant canopy for 220 seconds, with 6-second intervals. Then, the same plants were treated with Fluoricum acidum 30CH (Fl. ac. 30), and ten minutes later, new images of the leaves were taken to verify the possible existence of reaction patterns of the plants generated by Biospeckle Laser (1,2). Several types of imaging were performed to choose the image pattern, and the NIR type was chosen, generated by the Mobius camera connected directly to a laptop. The images were treated using the THSP algorithm, which generated data to compare the variation of pixel intensity with and without the presence of UHD. Research has shown that "Fl. ac. 30" is identified in purslane plants soon after application and this sign persists for at least 180 minutes after application, with a significant difference from the control at the 1% probability level.
Keywords: computational vision; homeopathy signal; dynamic laser speckle
Arsenicum album as a treatment for pneumonia in snakes: serial cases
Authors: Balbueno Melina Castilho de Souza , Martins Jéssica Amancio , Coelho Cidéli de Paula 
Published: September 2022

Abstract
Introduction: two Python bivittatus were received at Project Selva Viva, zoo in Taubaté, Brazil, both presented respiratory noises and oro-nasal discharge. In view of the fact, a thoracic ultrasonographic examination was performed for evaluation on February 25, 2022, which diagnosed the presence of multiple vertical hyperechoic artefacts emerging from the pleural line, coalescing in some of the fields evaluated, and the presence of a hypoechoic structure located in the subpleural region. Another serpent, a species of Boa constrictor, arrived in same zoo, unhistorical individual, collected from an apprehension, showed a low body score and during a thoracic ultrasonographic evaluation, carried out on April 1, 2022, was also found to have B waves emerging from the line pleural. Methodology: Authorized story, by responsible of zoo. In all the patients, homeopathic therapy was initiated with 2 globules of Arsenicum album 30 cH/BID, after diagnosis of the respiratory condition by ultrasonographic examination, the medication was chosen through the similarity with the symptoms. Accompaniment with ultrassoms of Python bivittatus foram carried out weekly for accompaniment of the respiratory picture. Results: On March 04, it was observed that both coils showed a reduction in respiratory noise and were more active. Ars 30 cH was maintained BID. On March 25, both presented significant improvement in ultrasound, which made visible only lines A, compatible with a healthy lung, in both individuals and the treatment was suspended. The treatment of the Boa constrictor was started on April 1. On April 8, ultrasonographic examination was performed, which only observed lines A, indicating improvement of the picture. Conclusion: Given these results, it is considered that the homeopathic treatment is an option to be considered not treating the respiratory condition in snakes, however, there is variation in the duration of the therapy through the stage and chronicity of the disease.
FAKTOR POSITIVE DEVIANCE KARAKTERISTIK KELUARGA MISKIN DENGAN STATUS GIZI ANAK USIA 0-24 BULAN DI WILAYAH KERJA PUSKESMAS MEDAN AMPLAS TAHUN 2019
Authors: FITRIANI EVI - 
Published: September 2022

The critical condition of the growth and development of a child aged 0 – 24 months is called a “critical period” because in this age the child undergoes very fast physical growth and brain development so that he needs good nutrition. Positive deviance is used to explain some factors which influence the growth and good nutrition status of children who live in poor families and in poor environment, where most of them undergo abnormal growth and development with malnutrition condition.
The objective of the research was to analyze factors influence the nutrition status of child aged 0 – 24 months by positive deviance in quantitative study with complement qualitative with a survey by cross sectional approach, to collect data of characteristic of family, characteristic of child and the behavior of parent in care the child and its influence to the nutrition status with positive deviance review and to study efforts of parent in order to increase the nutrition status of child aged 0 – 24 months in Amplas Puskesmas. The number of sample in this research for qualitative study is 100 respondents taken by proportional sampling method from 10 villages. The data were analyzed by using bivariate statistic analysis with Chi-square test in confidential level of 95% and multivariate analysis with logistic regression test with OR (CI 95%), and 5 mothers as informant for qualitative data.
The result of research showed that based on mother characteristic, child characteristic and mother’s behavior in taking care of child it was found from the results of statistic test that variables of education, occupation, birth weight, knowledge, attitude and interaction of mother and child have influence to the nutrition status of child aged 0 – 24 months from the poor family in AmplasPuskesmas, Districts Medan Amplas 2019 in which the dominant variable is a knowledge of mother with Exp (B) or Odd Ratio (OR) is 11.254 in Confidence Interval 95% in rage of 1.365 up to 52.754.
It is recommended to the local health office and Puskesmas to support the society/mothers in pay attention to the nutrition of the child and to increase the role of local posyandu to provide socialization, extension and counseling about the nutrition status of child that related to the nutrition status of child and to increase the knowledge of mother about health issue and how to care the child in order to increase the behavior and attitude of mother in maintain the nutrition status of child not based on education and occupation of the mother.
PENGARUH PRENATAL YOGA TERHADAP KETIDAKNYAMANAN PADA IBU HAMIL TRIMESTER III DI PUSKESMAS PARGARUTAN TAHUN 2020
Authors: Dewi Sri Sartika Sari , Napitupulu Mastiur , Nasution Ismayanti 
Published: September 2022

The discomfort that is often felt by pregnant women in the trimester such as frequent urination, diﬃculty sleeping, shortness of breath and back pain, fatigue and leg cramps that are often felt at night. The purpose of this study was to determine the effect of prenatal yoga on discomfort in third trimester pregnant women at Pargarutan Health Center. The type and design of the research was quantitative with a pre-experimental analytical design with a pretest-post test one group design approach. The population was all pregnant women in the third trimester at Pargarutan Health Center totaling 25 people, the sampling technique was the total population. Data analysis was univariate analysis and bivariate analysis with dependent T test. The conclusion showed that before doing prenatal yoga, the average discomfort for pregnant women in the third trimester was 1.560. After doing prenatal yoga, the average discomfort for pregnant women in the third trimester was 1.160. There is an effect of prenatal yoga on discomfort in third trimester pregnant women at Pargarutan Health Center with p value = 0.001 <α = 0.05. Midwives in carrying out pregnancy care should apply prenatal yoga in pregnant women classes so that pregnant women can do prenatal yoga independently.
Causes of Delay in Radiological Reporting and ways to Reduce them
Authors: Wahid Ghazala , Ammara Haroon  , Mehreen Samad  , Naila Tamkeen  
Published: September 2022

Background: Radiology reporting in today's era has a very important role in diagnosis and management of patient so it is very important to rule out the causes and ways to improve reporting time and its quality. Delays in performing radiology scans or interpreting them can prolong the time until a proper treatment decision can be made, leading to increased costs and potential compromises in patient care.Objective: To find out reasons for delay in radiological reporting and to find out how to reduce them and improve reporting standards.Materials and Methods: This study was an observational descriptive study and it involved data collected from all patients whose CT scan or MRI was performed for random problems in HMC. There scans were followed till they were reported and handed over to patients or patient's attendants. Questionnaires were given to five consultants of radiology department to know about causes of delay.Results: In this observational study we found that delay in reporting was multifactorial. Approximately 11,600 CT scans and MRI scans were performed in the period between 1st July to 31st December 2018. Approximately 2070 (17.8%) reports were delayed more than 72 hours while 82.1% scan were reported in time within 72 hours. In our study the most important cause of delayed reporting was incomplete history (34.8%), while other causes were inappropriate technique (21.5%), radiologist overburden (29.7%) while in 14% patients the cause of delayed reporting was lack of communication between radiologist and clinician.Key Words: Computed tomography, Magnetic resonance imaging, Reporting.
Political Role of Muslims Students and Women During Pakistan Moment 1936-1947
Authors: Akhtar Dr. Sohail , Saleem Bashaa , Sirwar Azhar Maqsood 
Published: September 2022

Hundred years of Muslim’s rule in subcontinent has become end with the tragic story of decline. The rulers of time turned into slaves and their condition has become miserable. The new colonial masters oppressed them and used all tactics to crush them. As a result, Muslims lost their social, religious, political and cultural greatness, according to William Hunter, Muslims have changed from the richest class to the poorest. After the evolution of the two-nation theory, they felt the need to re-establish their identity and then decided on a political struggle. After the Allahabad address of 1930, when Quaid-e-Azam took over the political leadership, he soon realized that all sections of the Muslim community in the society must be involved in the political struggle. With this objective in mind, it was decided to set up the Muslim Students Federation and the Muslim League W omen's Branch. After their establishment, students and Muslim women performed their duties and responsibilities well. They played a key role in the struggle. It was their work that they transformed Muslim League into an electoral party. Student over women turned the successful election campaign of 1945-46 into a successful political struggle. During this time, Muslim students and women thwarted government tactics through their political roles. And the creation of Pakistan is due to their full political will. This paper highlights the political struggle of Muslim students and women during freedom moment of Pakistan.
antifungal activity and phytochemical of ethanol extracts from leaves of Azadirachta indica plants in Iraq
Authors: Jawad Douaa Abd Alhameed , AlGaraawi Neepal Imtair 
Published: September 2022

The present study appearing various compounds that have been isolated from Azadirachta indica and showed natural compounds from leaves against three typs of pathogenic fungi are as follows:" Alternaria alternate, Neoscytalidium dimidiatum and Sordaria fimicola" . The Phytochemical of of Azadirachta indica leaves were exposed to (GC-MS) analysis. The results showed highest activity against all reviewed fungal, in Alternaria alternate, Neoscytalidium dimidiatum and Sordaria fimicola. the three concentrations of extract (20,30,40 mg/ml) in respectively" were given a results ( 0.00) mm in the diameter of colonies. The GC-MS analysis of Azadirachta indica leaves parts showed the presence of : 1,3-Cyclohexadiene, 2-methyl-5-(1-methylethyl)- ؛(R)-(+)-Limonene ؛1-methyl-3-(1-methylethyl)-cyclohexane ؛ 1-Methyl-4-(1-methylethylidene)-2-1-methylvinyl)-1-vinylcyclohexane) ؛ trans-beta-caryophyllene ؛ Bicyclo [2.2.1]heptane, 2,2-dimethyl-3-methylene-,dimer ؛ 1R,1α,3α,4β-4-Ethenyl-α,α,4-trimethyl-3-(1-methylethenyl) cyclohexanemethanol diethyl benzene-1,2-dicarboxylate Neantine ؛Selinenol ؛ 2-(4a,8-Dimethyl-1,2,3,4,4a,5,6,8a-octahydro-2-naphthalenyl)-2-propanol؛ tert-Butyl(6-bromofuro[3,2-b]pyridin-2-yl)-methylcarbamate ؛ Palmitic acid (hexadecanoic acid) ؛Palmitic acid, ethyl ester ؛ 2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, (2E,7R,11R)- ؛ cis-9-Octadecenoic acid ؛9-Octadecenoic acid (Z)-, ethyl ester ؛ Behenic acid ethyl ester ؛ Oleic Acid_GurudeebanSatyavani ؛ Acetyl-O-anisidine ؛ 1-Hydroxy-3-methylbenzene ؛ 1-(1Z-octadecenyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine ؛ 23-[2-Methyl-1-(1-methylethyl)cyclopropyl]-24-nor-5alpha-cholane ؛ Nikko Squalane EX ؛ 24S-Ethylcholest-5-en-3β-ol ؛ (2-Dodecen-1-yl)succinic anhydride, technical
Comparative evaluation of caries removal efficacy using enzymatic gel BRIX 3000 and polymer burs in primary molars
Authors: Gunjal Pranjali , Chauhan Rashmi Singh , Tirupathi Sunnypriyatham , Patil Vishwas , Suvarna Ashrita , Shah Sejal 
Published: September 2022

Aim: The study compares and evaluates enzymatic gel Brix 3000â and Polymer bur (SS White) for caries excavation in primary molars in terms of two parameters such as pain reaction and the time taken for caries excavation. Method: 60 children aged 7-9 years who require caries removal were recruited for the study and were randomly allocated into two groups: Group-A: Enzymatic gel (Brix 3000)â, Group-B: Smart burs (SS White polymer burs). The objectives evaluated were, observed pain reaction of the child (SEM scale) during the procedure and the total time taken for caries excavation. Results: The results suggest a significant difference between among the groups Brix 3000â showed superior results compared to group B (Smart burs) i.e., use of Brix 3000â for caries excavation took less time and showed minimal pain reaction. Conclusion: We can conclude that the newer enzymatic gel Brix 3000 is a viable alternative to other minimally invasive procedures. Clinical Significance: Method practiced to minimise the treatment time and discomfort, especially in pediatric age group it becomes important factor to obtain child cooperation.