bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization and Prediction of Mobile Tasks
Authors: Tian Yuan , Zhou Ke , Pelleg Dan 
Published: March 2022

Mobile devices have become an increasingly ubiquitous part of our everyday life. We use mobile services to perform a broad range of tasks (e.g., booking travel or conducting remote office work), leading to often lengthy interactions with several distinct apps and services. Existing mobile systems handle mostly simple user needs, where a single app is taken as the unit of interaction. To understand users’ expectations and to provide context-aware services, it is important to model users’ interactions with their performed task in mind. To provide a comprehensive picture of common mobile tasks, we first conduct a small-scale user study to understand annotated mobile tasks in-depth, while we demonstrate that by using a set of features (temporal, similarity, and log sequence), we can identify if a pair of app usage belong to the same task effectively. Secondly, the proposed best task detection model is applied to a large-scale data set of commercial mobile app usage logs to infer characteristics of complex (multi-app) mobile tasks in the wild. By applying an unsupervised learning framework, we discover common mobile task types that span multiple apps based on various extracted characteristics. We observe that users generally perform 17 common tasks with 47 sub-tasks, ranging from “social media browsing” to “dining out” and “family entertainments”. Finally, we demonstrate that we can predict the next complex mobile task that users are likely to perform by leveraging features from the historically inferred mobile tasks and user contexts. Our work facilitates an in-depth understanding of mobile tasks at scale, enabling applications for promoting task-aware services.
Valorization of Posidonia-Oceanica leaves for the building insulation sector
Authors: Mehrez Insaf , Hachem Houda , Gheith Ramla , Jemni Abdelmajid 
Published: March 2022

A new bio-composite material appropriate for building thermal insulation is proposed. The hydrophilic, thermal, and mechanical properties of composites made with Posidonia-Oceanica leaves, are experimentally investigated. The effect of two different sizes of fibers (natural and crushed leaves) as well as the effect of the chemical treatment (1% sodium hydroxide) are studied. For this purpose, different parallelepipedic specimens of dimensions 270 × 270 × 30 mm3 (thermal properties tests) and 160 × 40 × 40 mm3 (mechanical properties tests) were prepared by varying densities of leaves (0, 5, 10, 15, 20, and 30% by volume). In comparison to the fiber size effect, the results reveal that fiber loading has a significant impact on the mechanical and thermal characteristics of composites. Alkali treatment can improve the compressive and flexural strength of bio-composites. The novel bio-composites have low thermal conductivity (0.09 W.m−1K−1 when 30% of reduced size Posidonia-Oceanica leaves were loaded into the reference mortar) and acceptable mechanical performances. Results also show (1) The addition of treated fiber improves the ductility of the material. (2) The fracture toughness is 75% greater than reference mortar. (3) The use of crushed fibers decreases the composite’s mechanical strengths. (4) The flexural strength decreases with the fibers content and increase after 1% sodium hydroxide treatment. It can be concluded that the proposed bio-composite can be employed as thermal insulation material.
Prognostic factors of severe pneumonia in patients treated with rituximab in the intensive care unit
Authors: Yao Lili , Huang Yu , Xu Andi 
Published: March 2022

Objective The aim of this study was to describe the clinical characteristics and prognostic factors of patients treated with rituximab (RTX) who developed severe pneumonia in the intensive care unit (ICU). Methods We systematically reviewed the medical records of 40 patients who received RTX and developed severe pneumonia in the ICU at our hospital from January 2009 to January 2019 to evaluate the underlying conditions, clinical course, and possible prognostic factors. Results Most patients had underlying hematologic malignancies (n = 21, 52.5%), followed by rheumatologic diseases (n = 17, 42.5%). The most frequent causative pathogens were fungi (n = 11, 27.5%), followed by bacteria (n = 9, 22.5%) and Pneumocystis jirovecii pneumonia (n = 8, 20%). Thirty patients (75%) died, and the other 10 patients (25%) survived. Compared with survivors, patients who died were significantly older (60.6 ± 10.6 vs 44.4 ± 18.3 years) and had chronic lung disease (40% vs 0%). Conclusion Older age and chronic lung disease were significantly associated with mortality in patients treated with RTX.
Evaluation of family and staff experiences with virtual rounding and bedside presence in a tertiary neonatal intensive care unit during the COVID-19 pandemic
Authors: Blagdon Ashley , Smith Dani , Bramfield Tara , Soraisham Amuchou , Mehrem Ayman Abou 
Published: March 2022

Introduction The COVID-19 pandemic-related visitation restrictions started in March 2020 in Alberta, Canada. In the Neonatal Intensive Care Unit, we implemented a Virtual Communications initiative to allow parents to continue to be present with their infants, attend daily rounds, and communicate with the medical team. The purpose of this survey study was to describe our approach and evaluate the experience for families and staff. Methods The study surveys consisted of 13–18 questions directed toward understanding staff and family experience with the process and emotional impact using Likert scale and open-ended questions. The study team reviewed results and implemented changes in real time. Analysis was mixed quantitative and qualitative design, with descriptive data organized into themes. Results Twenty-six surveys were completed by 16 staff (62%) and 10 parents (38%). About 50% to 100% of respondents agreed or strongly agreed with statements addressing the quality and value of the virtual sessions. Staff identified challenges with slow devices and need for awareness and education. Both staff and parents expressed gratitude for the initiative and an overall positive experience. Discussion Offering Virtual Rounds and Bedside Presence in the Neonatal Intensive Care Unit is a well-received and feasible alternative to in-person presence that allows parents to stay involved and connected to their infants. Families have a better understanding of their babies’ clinical status and plans with an overall positive experience.
Validation of the ASDAS with a quick quantitative CRP assay (ASDAS-Q) in patients with axial SpA: a prospective multicentre cross-sectional study
Authors: Proft Fabian , Schally Julia , Brandt Henning Christian , Brandt-Juergens Jan , Rüdiger Burmester Gerd , Haibel Hildrun , Käding Henriette , Karberg Kirsten , Lüders Susanne , Muche Burkhard , Protopopov Mikhail , Rademacher Judith , Rios Rodriguez Valeria , Torgutalp Murat , Verba Maryna , Zinke Silke , Poddubnyy Denis 
Published: March 2022

Objectives: The objective of the study was to validate the Ankylosing Spondylitis Disease Activity Score (ASDAS) based on a quick quantitative C-reactive protein (qCRP) assay (ASDAS-Q) in a multicentre, prospective, cross-sectional study in patients with axial spondyloarthritis (axial SpA). Methods: Disease activity assessment was performed in prospectively recruited patients with axial SpA. Routine laboratory CRP was determined in the central laboratory of each study centre, while quick qCRP and erythrocyte sedimentation rate (ESR) were measured locally. Consequently, ASDAS-CRP, ASDAS-Q using the qCRP and ASDAS-ESR were calculated. The absolute agreement on the disease activity category ascertainment was analysed with cross-tabulations and weighted Cohen’s kappa. Bland–Altman plots and intraclass correlation coefficients (ICCs) were used to analyse the criterion validity. Results: Overall, 251 axial SpA patients were included in the analysis. The mean qCRP value (6.34 ± 11.13 mg/l) was higher than that of routine laboratory CRP (5.26 ± 9.35 mg/l). The ICC for routine laboratory CRP versus qCRP was 0.985 [95% confidence interval (CI): 0.972–0.991]. Comparing ASDAS-Q with ASDAS-CRP, 242 of 251 (96.4%) patients were assigned to the same disease activity categories with a weighted Cohen’s kappa of 0.966 (95% CI: 0.943–0.988) and ICC of 0.997 (95% CI: 0.994–0.999). Conclusions: ASDAS-Q showed an almost perfect agreement with ASDAS-CRP in the assignment to specific disease activity categories. Consequently, ASDAS-Q using the qCRP value can be applied as an accurate and quickly available alternative to ASDAS-CRP, thus facilitating the implementation of the treat-to-target concept in clinical trials and clinical routine.
Documentation of Behavioral Health Risk Factors in a Large Academic Primary Care Clinic
Authors: Hosang Stephanie , Kithulegoda Natasha , Ivers Noah 
Published: March 2022

Objective: To determine the prevalence of alcohol, smoking, and physical activity status documentation at a family health team in Toronto, Ontario, and to explore the patient characteristics that predict documentation of these lifestyle risk factor statuses. Design: Manual retrospective review of electronic medical records (EMRs). Setting: Large, urban, academic family health team in Toronto, Ontario. Participants: Patients over the age of 18 that had attended a routine clinical appointment in March, 2018. Main Outcome Measures: Prevalence and content of risk factor status in electronic medical records for alcohol, smoking, and physical activity. Results: The prevalence of alcohol, smoking, and physical activity documentation was 86.4%, 90.4%, and 66.1%, respectively. These lifestyle risk factor statuses were most often documented in the “risk factors” section of the EMR (83.7% for alcohol, 88.1% for smoking, and 47.9% for physical activity). Completion of a periodic health review within 1 year was most strongly associated with documentation (alcohol odds ratio [OR] 9.79, 95% Confidence Interval [CI] 2.12, 45.15; smoking OR 1.77 95% CI 0.51, 6.20; physical activity OR 3.52 95% CI 1.67, 7.40). Conclusion: Documentation of lifestyle risk factor statuses is strongly associated with having a recent periodic health review. If “annual physicals” continue to decline, primary care providers should final additional opportunities to address these key determinants of health.
Comparative transcriptome analysis reveals significant differences in gene expression between pathogens of apple Glomerella leaf spot and apple bitter rot
Authors: Jiang Bowen , Cai Ting , Yang Xiaoying , Dai Yuya , Yu Kaixuan , Zhang Pingping , Li Pingliang , Wang Caixia , Liu Na , Li Baohua , Lian Sen 
Published: March 2022

Abstract
Background
Apple Glomerella leaf spot (GLS) and apple bitter rot (ABR) are two devastating foliar and fruit diseases on apples. The different symptoms of GLS and ABR could be related to different transcriptome patterns. Thus, the objectives of this study were to compare the transcriptome profiles of Colletotrichum gloeosporioides species complex isolates GC20190701, FL180903, and FL180906, the pathogen of GLS and ABR, and to evaluate the involvement of the genes on pathogenicity.

Results
A relatively large difference was discovered between the GLS-isolate GC20190701 and ABR-isolates FL180903, FL180906, and quite many differential expression genes associated with pathogenicity were revealed. The DEGs between the GLS- and ABR-isolate were significantly enriched in GO terms of secondary metabolites, however, the categories of degradation of various cell wall components did not. Many genes associated with secondary metabolism were revealed. A total of 17 Cytochrome P450s (CYP), 11 of which were up-regulated while six were down-regulated, and five up-regulated methyltransferase genes were discovered. The genes associated with the secretion of extracellular enzymes and melanin accumulation were up-regulated. Four genes associated with the degradation of the host cell wall, three genes involved in the degradation of cellulose, and one gene involved in the degradation of xylan were revealed and all up-regulated. In addition, genes involved in melanin syntheses, such as tyrosinase and glucosyltransferase, were highly up-regulated.

Conclusions
The penetration ability, pathogenicity of GLS-isolate was greater than that of ABR-isolate, which might indicate that GLS-isolate originated from ABR-isolates by mutation. These results contributed to highlighting the importance to investigate such DEGs between GLS- and ABR-isolate in depth.
miR-495-3p depresses cell proliferation and migration by downregulating HMGB1 in colorectal cancer
Authors: Zhang Jie Ling , Zheng Hui Fen , Li Kai , Zhu Yi Ping 
Published: March 2022

Abstract
Background
MicroRNAs play an important role in the genesis and progression of tumours, including colorectal cancer (CRC), which has a high morbidity and mortality rate. In this research, the role of miR-495-3p and HMGB1 in CRC was investigated.

Methods
We performed qRT-PCR to detect the expression of miR-495-3p in colorectal cancer tissues and cell lines. Functional experiments, such as CCK-8, EdU, Transwell and apoptosis assays, were conducted to explore the effects of miR-495-3p on the proliferation, migration and apoptosis of CRC cells in vitro. Then, database prediction, dual-luciferase reporter gene assays and functional experiments verified the role of the miR-495-3p target gene HMGB1 in CRC. Finally, rescue experiments were performed to investigate whether overexpression of HMGB1 could reverse the inhibitory effect of miR-495-3p on CRC cell proliferation in vivo and in vitro.

Results
miR-495-3p was downregulated in colorectal cancer tissues and cell lines, inhibited the proliferation and migration of colorectal cancer cells and promoted cell apoptosis. Database prediction and dual-luciferase reporter gene assays showed that HMGB1 was the downstream target gene of miR-495-3p. We finally demonstrated that miR-495-3p inhibited CRC cell proliferation by targeting HMGB1 in vitro and in vivo.

Conclusion
Our research shows that miR-495-3p inhibits the progression of colorectal cancer by downregulating the expression of HMGB1, which indicates that miR-495-3p may become a potential therapeutic target for colorectal cancer.
Intravenous oxygen insufflation (IOI) changes the IL-1-Ra:IL-1β ratio in autologous conditioned serum
Authors: König Brigitte , Wiechert Dirk 
Published: March 2022

Abstract
Background
Interleukin-1 (IL-1) is still regarded as the main offender that promotes the pro-inflammatory cascade in muscle injuries, tendopathies and especially in osteoarthritis. Thus, if present in high enough concentrations, IL-1receptor antagonist (IL-1Ra) has the potential to inhibit Interleukin-1. In this regard, autologous conditioned serum with an IL-1Ra/IL-1 ratio of at least > 10 might fulfill optimal therapeutic effects.
The aim of the study was to analyze whether a pretreatment of patients with the oxygen insuffliation according to Regelsberger (IOI) might lead to an increased ratio of IL-RA to IL-1ß in autologous serum prepared after the respective therapy.

Methods
Venous blood from 15 patients which underwent intravenous oxygen insufflation (IOI) for routinely preventive purposes was taken before the first, the 6th, and the 9th session of intravenous oxygen insufflation. IL-1β and IL-1-RA levels were quantified from serum and from autologous conditioned serum (ACS) prepared from the drawn venous blood.

Results
Previous intravenous oxygen insufflation treatments significantly reduced IL-1β levels in autologous conditioned serum from mean 67.85 pg/ml (before the first treatment) down to mean 4.08 pg/ml (before the 9th treatment). Post conditioning levels of IL-1Ra were not changed to any significant degree (before 1st/before6th/ before 9th treatment: 1038.37 ± 140.51 / 900.30 ± 79.24 / 902.84 ± 95.68). Thus, the IL-1Ra:IL-1β ratio was altered on a molecule to molecule basis from a mean of 37.03:1 up to a mean 223.54:1 through the pretreatment with oxygen insuffliation according to Regelsberger.

Conclusion
Pretreatment of patients with IOI alters the IL-1Ra:IL-1ß ratio of autologous conditioned serum to a more favorable ratio which might mitigate the inflammatory cascade more efficaciously. Therefore, we suggest to perform intravenous oxygen insufflation on patients before they give blood for preparing ACS.
Machine-Learning-Based Return Predictors and the Spanning Controversy in Macro-Finance
Authors: Huang Jing-Zhi , Shi Zhan 
Published: March 2022

We propose a two-step machine learning algorithm—the Supervised Adaptive Group LASSO (SAGLasso) method—that is suitable for constructing parsimonious return predictors from a large set of macro variables. We apply this method to government bonds and a set of 917 macro variables and construct a new, transparent, and easy-to-interpret macro variable with significant out-of-sample predictive power for excess bond returns. This new macro factor, termed the SAGLasso factor, is a linear combination of merely 30 selected macro variables out of 917. Furthermore, it can be decomposed into three sublevel factors: a novel housing factor, an employment factor, and an inflation factor. Importantly, the predictive power of the SAGLasso factor is robust to bond yields, namely, the SAGLasso factor is not spanned by bond yields. Moreover, we show that the unspanned variation of the SAGLasso factor cannot be attributed to yield measurement error or macro measurement error. The SAGLasso factor therefore provides a potential resolution to the spanning controversy in the macro-finance literature.This paper was accepted by Haoxiang Zhu, finance.Funding: This work was supported by a grant from the Penn State Institute for Real Estate Studies.Supplemental Material: Data and the internet appendices are available at https://doi.org/10.1287/mnsc.2022.4386 .
Investigating the influence of ITO thin film thickness on the optical Kerr nonlinearity using ultrashort laser pulses
Authors: Samad Fatma Abdel , Mahmoud Alaa , Abdel-Wahab M. Sh. , Tawfik Wael Z. , Zakaria Rozalina , Soma Venugopal Rao , Mohamed Tarek 
Published: March 2022

In this paper, we present results from the measurements of the optical Kerr nonlinearity of indium tin oxide (ITO) thin films of different thicknesses using the femtosecond (fs) Z-scan technique. ITO thin films were prepared by radio frequency magnetron sputtering on a glass substrate at room temperature. The coated ITO thin films were subsequently characterized by UV–visible absorption spectroscopy, x-ray diffraction, and scanning electron microscopy. Using

∼

100

f
s

pulses at 80 MHz repetition rate, the optical Kerr nonlinearity in ITO with different thicknesses was investigated at different excitation wavelengths and incident pulse energies. The optical Kerr nonlinearity was found to be dependent on excitation wavelength, incident power, and ITO thickness, with a maximum value of

∼

9

×

1

0

−
12

c
m

2

/

W

at a wavelength of 820 nm, power of 1 W, and 170 nm ITO thickness. These results suggest that Kerr nonlinearity in ITO can be tailored by varying the film thickness, which would be ideal for ultrafast all-optical switching in future optoelectronic devices.
PROJETO TERAPÊUTICO SINGULAR (PTS) E INTERPROFISSIONALIDADE: UM RELATO DE ESTUDANTES DO PET SAÚDE. Singular therapeutic project and interprofessionality (PTS) - a report by students from PET health
Authors: Almeida Gizelle Noronha , Freitas Cibelly Aliny Lima , Ponte Filho Aristides Parente , Vasconcelos Polyanne Rodrigues , Ferreira Wallace Aguiar , Dos Santos Ricardo Lima , De Araújo Maria Socorro Dias 
Published: March 2022

Em um ambiente que trabalhe vários profissionais, com formações diferentes e com visões terapêuticas diferentes, naturalmente irá aparecer dificuldades em promover um projeto terapêutico comum ao paciente, que considere o indivíduo na sua integralidade. Nessa perspectiva, o PTS - que é uma agregação de propostas de atuações terapêuticas articuladas para um indivíduo, família ou grupo – é uma ferramenta que auxilia na busca de uma singularidade de ações a partir do diagnóstico firmado. A sistematização da experiência se deu em maio e junho de 2019. O objetivo foi relatar a utilização do PTS como instrumento de trabalho interprofissional. Trata-se de um ensaio descritivo do tipo relato de experiência sistematizado por integrantes do PET-Saúde Interprofissionalidade de Sobral, Ceará. O cenário do estudo foi o CAPS Damião Ximenes Lopes, Sobral-Ce. A construção do PTS no CAPS se dá por meio de uma reunião, denominada “roda de discussão”, onde os diferentes atores do processo elaboram juntos estratégias de promoção à saúde. Logo, é o momento que o prontuário de algum usuário do serviço é escolhido para ser debatido entre os profissionais segundo suas especialidades, porém, as abordagens de intervenção são pensadas em equipe. Desse modo, o PTS se configura como um aliado na resolução de questões que acompanham os sujeitos assistidos no contexto da saúde mental, uma vez que o caráter dinâmico e complexo presente nos equipamentos que atuam com a interprofissionalidade exigem profissionais capazes de assegurar uma melhor atenção à saúde, dispondo de respostas necessárias para as múltiplas demandas trazidas pelos pacientes.
Comparative Conceptology of Power and Resistance Using Google Ngram Books
Authors: Oleinik Anton 
Published: March 2022

The article discusses the evolution of key concepts referring to governmentality in comparative perspective. The Russian discourse on government and power is compared with the Western discourse. The Google Books Ngram Viewer databank covering the period from 1800 to 2019 is used as a source of information. This databank contains more than 5 % of all published books. The proposed discourse analysis suggests that the Russian and Western discourses have some elective affinity: in both cases there is little room for truth telling and whistle-blowers face significant risk.
Evaluating the importance of translocations in rescuing the genetic diversity of the endemic Saimaa ringed seal
Authors: Sundell Tarja , Kammonen Juhana I , Mustanoja Ella , Biard Vincent , Kunnasranta Mervi , Niemi Marja , Nykänen Milaja , Nyman Tommi , Palo Jukka U , Valtonen Mia , Paulin Lars , Jernvall Jukka , Auvinen Petri 
Published: March 2022

Abstract
Fragmentation of isolated populations increases the risk of inbreeding and loss of genetic diversity. The endemic Saimaa ringed seal (Pusa hispida saimensis) is one of the most endangered pinnipeds in the world with a population of only ~400 individuals. The current genetic diversity of this subspecies, isolated in Lake Saimaa in Finland for ca. 1,000 generations, is alarmingly low. The population is further divided into semi-isolated subpopulations in the labyrinthine landscape of the lake, which exposes the population to deleterious genomic effects. We performed whole-genome sequencing on Saimaa ringed seals (N=30) and analyzed the level of homozygosity and genetic composition across the individual genomes. Our results show that the Saimaa ringed seal population has a high number of runs of homozygosity (RoH) compared with the neighboring Baltic ringed seal (Pusa hispida botnica) reference population (p<0.001). We found a general signal of differentiation in homozygosity within Lake Saimaa subpopulations (p<0.05) and detected thousands of unique single-nucleotide polymorphisms (SNPs) in all subpopulations. The observed high levels of inbreeding and the risk of losing indispensable SNPs may directly affect fitness in individuals. These results support augmented gene flow as a genetic conservation action. Based on our results, we recommend Pihlajavesi as a potential source and Southern Saimaa as a potential recipient subpopulation for translocating individuals. The Saimaa ringed seal is a recognized subspecies and therefore translocations should be considered only within the lake to avoid an unpredictable risk of disease, the introduction of deleterious alleles, and severe ecological issues for the population.