bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dark energy and extending the geodesic equations of motion: A spectrum of galactic rotation curves
Authors: Speliotopoulos Achilles D. 
Published: July 2022

AbstractA recently proposed extension of the geodesic equations of motion, where the worldline traced by a test particle now depends on the scalar curvature, is used to study the formation of galaxies and galactic rotation curves. This extension is applied to the motion of a fluid in a spherical geometry, resulting in a set of evolution equations for the fluid in the nonrelativistic and weak gravity limits. Focusing on the stationary solutions of these equations and choosing a specific class of angular momenta for the fluid in this limit, we show that dynamics under this extension can result in the formation of galaxies with rotational velocity curves (RVC) that are consistent with the Universal Rotation Curve (URC), and through previous work on the URC, the observed rotational velocity profiles of 1100 spiral galaxies. In particular, a spectrum of RVCs can form under this extension, and we find that the two extreme velocity curves predicted by it brackets the ensemble of URCs constructed from these 1100 velocity profiles. We also find that the asymptotic behavior of the URC is consistent with that of the most probable asymptotic behavior of the RVCs predicted by the extension. A stability analysis of these stationary solutions is also done, and we find them to be stable in the galactic disk, while in the galactic hub they are stable if the period of oscillations of perturbations is longer than $$0.91_{\pm 0.31}$$

0
.

91

±
0.31

to $$1.58_{\pm 0.46}$$

1
.

58

±
0.46

billion years.
Industry-Led Standards, Relational Contracts and Good Faith: Are the UK and Australia Setting the Pace in (Construction) Contract Law?
Authors: Christie David , Saintier Séverine , Viven-Wilksch Jessica 
Published: July 2022

AbstractThe law of contract is changing. “Good faith” and “relational contracts” are used by parties more than ever before in commercial disputes. Yet, their definition and what it really means to act in good faith are still unsettled in the UK and Australia, reducing the (judicial and doctrinal) utility and impact of such conceptual tools. In contrast, the construction industry is trying to move forward in policy terms. Over the last 30 years, industry-led initiatives have been working to improve collaboration. In the UK and Australia, new collaborative frameworks contain express provisions asking parties to act with mutual trust and cooperation among other collaborative schemes. Examination of the judicial approach and industry initiatives demonstrates that there is – underpinning both – a project-centric approach (even if that is yet to be fully recognised or articulated). It is the aim of this paper to further articulate this understanding by examining at the judicial and industry positions in the UK and Australia.
How many ways can you die? Multiple biological deaths as a consequence of the multiple concepts of an organism
Authors: Nowak Piotr Grzegorz , Stencel Adrian 
Published: July 2022

AbstractAccording to the mainstream position in the bioethical definition of death debate, death is to be equated with the cessation of an organism. Given such a perspective, some bioethicists uphold the position that brain-dead patients are dead, while others claim that they are alive. Regardless of the specific opinion on the status of brain-dead patients, the mere bioethical concept of death, according to many bioethicists, has the merit of being unanimous and univocal, as well as grounded in biology. In the present article, we challenge such a thesis. We provide evidence that theoretical biology operates with a plurality of equally valid organismic concepts, which imply different conclusions regarding the organismal status of a brain-dead patient. Moreover, the theoretical biology concepts of an organism are very distant from the view on an organism that appears by way of bioethicists theorizing on death. We conclude that if death is to be understood as the cessation of an organism, there is no single correct answer to the question of whether a brain-dead patient is alive or dead.
Writing composition ability and spelling competence in deaf subjects: a psycholinguistic analysis of source of difficulties
Authors: Vizzi Francesca , Angelelli Paola , Iaia Marika , Risser Anthony H. , Marinelli Chiara Valeria 
Published: July 2022

AbstractWe studied the compositional written skills and spelling competence of individuals with a severe hearing impairment, examining qualitative and quantitative characteristics of their texts, the psycholinguistic variables modulating their productions, and writing errors following a fine-grained analysis. Sixteen deaf young adults, educated in bilingual settings, were examined and compared to a group of control hearing subjects matched for gender, age, and education. Writing skills were examined through both written composition and written picture-naming tasks. Concerning compositional skills, deaf participants produced shorter and less informative texts, with fewer adjectives and subordinates, and were qualitatively worse with respect to texts produced by hearing controls. Words produced by deaf participants were those acquired earlier and facilitated by a higher lexical neighbourhood. Errors were mainly semantic, morphological, and syntactic errors, reflecting general linguistic weakness. Spelling errors were few, with phonologically nonplausible misspellings relative to controls, and with phonologically plausible ones being quite rare. In the picture-naming task, deaf people had a greater number of all types of errors with respect to their text, including semantic and morphological errors. Their spelling performance featured mainly phonologically nonplausible misspellings, while phonologically plausible ones were relatively few and comparable to controls. Overall, the writing of deaf adults reveal limitations in grammar and lexical-sematic linguistic competence. This was associated with spelling deficits characterized mainly by the poorer use of phonological sublexical spelling procedures. However, in an ecologic context, their spelling deficits appear not so important as has been claimed in the literature.
Facts and Values After David Hume
Authors: Määttänen Pentti 
Published: July 2022

AbstractAccording to David Hume values do not belong to the world of facts and cannot be derived from facts. However, Hume’s argument is based on questionable presumptions. His conception of experience as sense perception is erroneous. On contemporary standards it is simply false because sense organs are not channels that passively receive inputs from the world. It is too narrow as it does not take the role of action into account. Further, Hume’s argument is based on the dichotomy between external and internal. Mind is strictly separated from the external world of facts. This entails that experiences, perceptions and ideas do not belong to the world of facts. Causality and values cannot be literally perceived. Therefore they are beyond the scope of empirical knowledge. Hume’s presumptions can be rejected. The consequence is that mind is embodied, and bodies belong to the world of facts. And so do embodied minds. Broadening the notion of experience brings causality and values within the scope of experience. They are experienced on a daily basis in various practices. Values related to vital needs are based on biological facts. More generally, the relation of facts and values can be analyzed if one rejects the hidden causes of perceptions as the object of knowledge. The alternative is the operational conception of knowledge. To know is to know what to do in order to proceed from a problematic situation to future circumstances where the problems are solved.
Motion Capture Sensing Technologies and Techniques: A Sensor Agnostic Approach to Address Wearability Challenges
Authors: Haratian Roya 
Published: July 2022

AbstractBody area sensing systems specifically designed for motion capture need to consider the wearer’s comfort and wearability criteria. In this paper, after studying body models and their approximation by link-segment models, the kinematics and inverse kinematics problems for determining motion are explored. Different sensor technologies and related motion capture systems are then discussed within the context of wearability and portability challenges of the systems. For such systems, the weight and size of the system need to be kept small and the system should not interfere with the user’s movements. The requirements will be considered in terms of portability: portable motion capture systems should be less sensitive in accurate positioning of sensors and have more battery lifetime or less power consumption for their wider adoption as an assisted rehabilitation platform. Therefore, a proposed signal processing technique is validated in a controlled setting to address the challenges. By reducing sampling frequency, the power consumption will be reduced but there would be more variability in data whereas by utilising an adaptive filtering approach the variation can be compensated for. It is shown how by using the technique it is possible to reduce the energy consumption; therefore, the potential to decrease the battery size leading to a less bulky on-body sensing system with more comfort to the wearer.
The incidence and outcome of AKI in patients with sepsis in the emergency department applying different definitions of AKI and sepsis
Authors: Cobussen Maarten , Verhave Jacobien C. , Buijs Jacqueline , Stassen Patricia M. 
Published: July 2022

Abstract
Background
Sepsis is often accompanied with acute kidney injury (AKI). The incidence of AKI in patients visiting the emergency department (ED) with sepsis according to the new SOFA criteria is not exactly known, because the definition of sepsis has changed and many definitions of AKI exist. Given the important consequences of early recognition of AKI in sepsis, our aim was to assess the epidemiology of sepsis-associated AKI using different AKI definitions (RIFLE, AKIN, AKIB, delta check, and KDIGO) for the different sepsis classifications (SIRS, qSOFA, and SOFA).

Methods
We retrospectively enrolled patients with sepsis in the ED in three hospitals and applied different AKI definitions to determine the incidence of sepsis-associated AKI. In addition, the association between the different AKI definitions and persistent kidney injury, hospital length of stay, and 30-day mortality were evaluated.

Results
In total, 2065 patients were included. The incidence of AKI was 17.7–51.1%, depending on sepsis and AKI definition. The highest incidence of AKI was found in qSOFA patients when the AKIN and KDIGO definitions were applied (51.1%). Applying the AKIN and KDIGO definitions in patients with sepsis according to the SOFA criteria, AKI was present in 37.3% of patients, and using the SIRS criteria, AKI was present in 25.4% of patients. Crude 30-day mortality, prolonged length of stay, and persistent kidney injury were comparable for patients diagnosed with AKI, regardless of the definition used.

Conclusion
The incidence of AKI in patients with sepsis is highly dependent on how patients with sepsis are categorised and how AKI is defined. When AKI (any definition) was already present at the ED, 30-day mortality was high (22.2%). The diagnosis of AKI in sepsis can be considered as a sign of severe disease and helps to identify patients at high risk of adverse outcome at an early stage.
Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli
Authors: Valle Antonio , Soto Zamira , Muhamadali Howbeer , Hollywood Katherine A. , Xu Yun , Lloyd Jonathan R. , Goodacre Royston , Cantero Domingo , Cabrera Gema , Bolivar Jorge 
Published: July 2022

Abstract
Introduction
Glycerol is a byproduct from the biodiesel industry that can be biotransformed by Escherichia coli to high added-value products such as succinate under aerobic conditions. The main genetic engineering strategies to achieve this aim involve the mutation of succinate dehydrogenase (sdhA) gene and also those responsible for acetate synthesis including acetate kinase, phosphate acetyl transferase and pyruvate oxidase encoded by ackA, pta and pox genes respectively in the ΔsdhAΔack-ptaΔpox (M4) mutant. Other genetic manipulations to rewire the metabolism toward succinate consist on the activation of the glyoxylate shunt or blockage the pentose phosphate pathway (PPP) by deletion of isocitrate lyase repressor (iclR) or gluconate dehydrogenase (gnd) genes on M4-ΔiclR and M4-Δgnd mutants respectively.

Objective
To deeply understand the effect of the blocking of the pentose phosphate pathway (PPP) or the activation of the glyoxylate shunt, metabolite profiles were analyzed on M4-Δgnd, M4-ΔiclR and M4 mutants.

Methods
Metabolomics was performed by FT-IR and GC–MS for metabolite fingerprinting and HPLC for quantification of succinate and glycerol.

Results
Most of the 65 identified metabolites showed lower relative levels in the M4-ΔiclR and M4-Δgnd mutants than those of the M4. However, fructose 1,6-biphosphate, trehalose, isovaleric acid and mannitol relative concentrations were increased in M4-ΔiclR and M4-Δgnd mutants. To further improve succinate production, the synthesis of mannitol was suppressed by deletion of mannitol dehydrogenase (mtlD) on M4-ΔgndΔmtlD mutant that increase ~ 20% respect to M4-Δgnd.

Conclusion
Metabolomics can serve as a holistic tool to identify bottlenecks in metabolic pathways by a non-rational design. Genetic manipulation to release these restrictions could increase the production of succinate.
Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats
Authors: Abd-Elhakim Yasmina M. , Abdel-Motal Sabry M. , Malhat Seham M. , Mostafa Hend I. , Ibrahim Walied M. , Beheiry Rasha R. , Moselhy Attia A.A. , Said Enas N. 
Published: July 2022

AbstractThis study aimed to investigate the effectiveness of curcumin (CCM) against gentamicin (GEN) and sodium salicylates (NaS)-induced ototoxic effects in rats. For 15 consecutive days, seven rat groups were given 1 mL/rat physiological saline orally, 1 mL/rat olive oil orally, 50 mg/kg bwt CCM orally, 120 mg/kg bwt GEN intraperitoneally, 300 mg/kg bwt NaS intraperitoneally, CCM+GEN, or CCM+NaS. The distortion product otoacoustic emission measurements were conducted. The rats’ hearing function and balance have been behaviorally assessed using auditory startle response, Preyer reflex, and beam balance scale tests. The serum lipid peroxidation and oxidative stress biomarkers have been measured. Immunohistochemical investigations of the apoptotic marker caspase-3 and the inflammatory indicator nuclear factor kappa (NF-κB) in cochlear tissues were conducted. GEN and NaS exposure resulted in deficit hearing and impaired ability to retain balance. GEN and NaS exposure significantly decreased the reduced glutathione level and catalase activity but increased malondialdehyde content. GEN and NaS exposure evoked pathological alterations in cochlear and vestibular tissues and increased caspase-3 and NF-κB immunoexpression. CCM significantly counteracted the GEN and NaS injurious effects. These outcomes concluded that CCM could be a naturally efficient therapeutic agent against GEN and NaS-associated ototoxic side effects.
Graphical abstract
The variation and trends of nitrogen cycling and nitrogen isotope composition in tree rings: the potential for fingerprinting climate extremes and bushfires
Authors: Succarie Amal , Xu Zhihong , Wang Wenjie 
Published: July 2022

Abstract
Purpose
Climate extremes, such as droughts and floods, have become intensified and more frequent due to intensifying climate change. Increased atmospheric carbon dioxide (CO2) and warming-induced water limitation, as well as climate extremes, may alter carbon (C) and nitrogen (N) cycling in forest ecosystems. This provides a brief review of stable nitrogen isotopic composition (δ15N) in tree ring in relation to climate extremes and bushfires in context of N availability and losses in forest ecosystems.

Material and methods
Tree rings were extracted from four Pinus sylvestris and four Larix gmelinii sample trees, located in a boreal plantation forest of Mohe City, Heilongjiang Province, China. Tree rings were measured to obtain mean annual basal area increment (BAI), while tree ring δ15N and total N concentrations were measured on mass spectrometer at 3-year intervals. The tree ring δ15N data were related to possible climate extremes and bushfires. A brief review of the relevant literature was also undertaken to support our preliminary research findings.

Results and discussion
Globally, increasing atmospheric CO2 concentration and water limitations have led to a warmer-drier climate. This has also been associated with increases of climate extremes such as drought and floods as well as bushfires. These extremes have been recorded with detrimental effects on plant and soil structures within forest ecosystems and play an important role in regulating N availability and losses in forest ecosystems. Studies of N deposition within forest ecosystems using soil and plant δ15N also showed that N losses under various climate extremes can occur through direct changes in N cycling, such as increasing soil nitrification and denitrification or leaching. It is highlighted that tree rings δ15N has the potential to fingerprint the intensity and frequency of climate extremes and bushfires in the forest ecosystems, but more such tree ring δ15N research needs to be done in diversified forest ecosystems to confirm the potential of using tree ring δ15N for quantifying the frequency and intensity of climate extremes and bushfires at both regional and global scale.

Conclusion
The variation and trend of δ15N in the soil–plant-climate systems are closely linked to the N cycling in forest ecosystems, and tree ring δ15N has the great potential to fingerprint both intensity and frequency of climate extremes such as drought and floods as well as bushfires.
Die Arbeitsbeziehung im Coaching: Ein Forschungsüberblick und Handlungsempfehlungen für die Praxis
Authors: Graßmann Carolin 
Published: July 2022

ZusammenfassungEine gelingende Arbeitsbeziehung zwischen Coach und Coachee ist einer der zentralen Erfolgsfaktoren im Coaching und kann erklären, warum manche Coachingprozesse erfolgreicher verlaufen als andere. Dieser Beitrag liefert einen Überblick über den Stand der Forschung zur Arbeitsbeziehung im Coaching. Er zeigt die Bedeutung der Arbeitsbeziehung zu verschiedenen Outcome-Ergebnissen für Coachees auf sowie Faktoren, die die Arbeitsbeziehung fördern oder auch nicht fördern können. Darüber hinaus wird die Rolle der Arbeitsbeziehung im digitalen Coaching-Setting näher beleuchtet. Der Beitrag benennt offene Fragen für die Coaching-Forschung und leitet Handlungsempfehlungen für die Coaching-Praxis ab.
Bias in algorithms of AI systems developed for COVID-19: A scoping review
Authors: Delgado Janet , de Manuel Alicia , Parra Iris , Moyano Cristian , Rueda Jon , Guersenzvaig Ariel , Ausin Txetxu , Cruz Maite , Casacuberta David , Puyol Angel 
Published: July 2022

AbstractTo analyze which ethically relevant biases have been identified by academic literature in artificial intelligence (AI) algorithms developed either for patient risk prediction and triage, or for contact tracing to deal with the COVID-19 pandemic. Additionally, to specifically investigate whether the role of social determinants of health (SDOH) have been considered in these AI developments or not. We conducted a scoping review of the literature, which covered publications from March 2020 to April 2021. ​Studies mentioning biases on AI algorithms developed for contact tracing and medical triage or risk prediction regarding COVID-19 were included. From 1054 identified articles, 20 studies were finally included. We propose a typology of biases identified in the literature based on bias, limitations and other ethical issues in both areas of analysis. Results on health disparities and SDOH were classified into five categories: racial disparities, biased data, socio-economic disparities, unequal accessibility and workforce, and information communication. SDOH needs to be considered in the clinical context, where they still seem underestimated. Epidemiological conditions depend on geographic location, so the use of local data in studies to develop international solutions may increase some biases. Gender bias was not specifically addressed in the articles included. The main biases are related to data collection and management. Ethical problems related to privacy, consent, and lack of regulation have been identified in contact tracing while some bias-related health inequalities have been highlighted. There is a need for further research focusing on SDOH and these specific AI apps.
Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study
Authors: Wang Junxia , Wu Sichu , Sun Yi , Lu Jiaming , Zhang Jilei , Fang Yu , Qing Zhao , Liang Xue , Zhang Wen , Chen Qian , Zhang Xin , Zhang Bing 
Published: July 2022

Abstract
Kidney and brain expressed protein (KIBRA) rs17070145 is associated with working memory function and cognitive processes. However, the neural mechanisms underlying these associations are not fully understood. This study aimed to explore the effect of KIBRA polymorphism on brain microstructure and blood oxygenation level dependent (BOLD) fluctuations using diffusion kurtosis imaging (DKI) and resting-state functional magnetic resonance imaging (fMRI) in 163 young adults. We also investigated that whether the imaging alterations mediated the association between KIBRA gene and working memory performance. Voxel-based analysis of DKI data showed that KIBRA C-allele carriers exhibited increased axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) as well as decreased fractional anisotropy (FA), mean kurtosis (MK) and radial kurtosis (RK) compared with KIBRA TT homozygotes, primarily involving the prefrontal lobe, left precuneus and the left superior parietal white matter. Meanwhile, KIBRA C-allele carriers exhibited decreased amplitude of low-frequency fluctuation (ALFF) in the left precuneus compared to KIBRA TT homozygotes. Mediation analysis revealed that the DKI metrics (MK and RK) of the left precuneus mediated the effect of the KIBRA polymorphism on working memory performance. Moreover, the MK and RK in the left precuneus were positively correlated with ALFF in the same brain region. These findings suggest that abnormal DKI parameters may provide a gene-brain-behavior pathway in which KIBRA rs17070145 affects working memory by modulating brain microstructure in the left precuneus. This illustrates that DKI may provide additional biological information and reveal new insights into the neural mechanisms of the KIBRA polymorphism.