bluuebunny/crossref_metadata_2025_split huggingface dataset:
Debris-Flow Channel Headwater Dynamics: Examining Channel Recharge Cycles With Terrestrial Laser Scanning
Authors: Bonneau David A. , Hutchinson D. Jean , McDougall Scott , DiFrancesco Paul-Mark , Evans Trevor 
Published: August 2022

Debris-flows present a natural hazard to the safe operation of linear infrastructure in mountainous environments. The most significant contributor to debris-flow occurrence is a supply of readily erodible material, often created by rockfalls and other shallow landslides. The spatial distribution and total volume of storage are also critical factors, controlling the initiation location, predominant flow type, and termination location of debris-flow surges. Therefore, there is a need to be able to systematically incorporate debris recharge processes and timeframes into the monitoring and characterization of debris-flow hazards. In this work, the authors present the results of 7 years of terrestrial laser scanning (TLS) captured at the White Canyon. The White Canyon represents an analog to large scale, steep catchments to investigate the role of sediment supply on debris-flow processes. The TLS dataset was collected at monthly to quarterly intervals, providing a basis for analysis of debris transfer processes occurring on the study slope. A rockfall database of over 72,000 events was generated from 52 change detection analyses and is linked to catchment recharge and transfer processes. The results indicate that the 17 channels analyzed in the White Canyon do not directly match the conceptual models proposed from the supply theory. The channels display a variety of behaviors when exposed to the same climate signature. The temporal data acquisition rate was found to have a significant influence on the dynamics of movement that can be interpreted from TLS change detection analysis. The work highlights the need for higher frequency monitoring and the integration of climate data into the analysis, in order to better understand these dynamic processes.
Thermal unrest of a fumarolic field tracked using VIIRS imaging bands: The case of La fossa crater (Vulcano Island, Italy)
Authors: Coppola D. , Laiolo M. , Campus A. , Massimetti F. 
Published: August 2022

Detecting precursory signals before an eruption is one of the main objectives of applied volcanology. Among these signals, the variation of the emitted heat flux is certainly an important indicator of a state of disequilibrium within the magmatic system. Here we report the results of a detailed analysis of VIIRS (Visible Infrared Imaging Radiometer Suite) imaging bands (at 375 m spatial resolution) focused on measuring the Volcanic Radiative Power (VRP) emitted by the fumarole field of La Fossa crater (Vulcano Island, Italy) over the past decade (2012–2022). The analysis reveals that the long-term, steady-state VRP (baseline ∼0.17 MW) was perturbed in 2020–2021 when a prolonged period of lower than normal (&lt;-2σ) radiant flux preceded the major unrest phase that began in mid-September 2021. By early October the anomalous VRP had peaked at ∼1.2 MW (6–8 times the baseline) then started to gradually decline in the following months. A subsequent thermal pulse was recorded in May–July 2022 and was accompanied by a period of seawater discoloration that affected the Baia di Levante (a shallow sea bay ∼1.4 km north of La Fossa crater). The concomitance of these phenomena suggests the occurrence of a second pressurization phase driven by the arrival of deep magmatic fluids within both the central and distal degassing fumarolic zones. These results provide a complementary, important contribution to the understanding of the unrest of La Fossa crater and highlight the potential of VIIRS in detecting pre-eruptive signals at other poorly-monitored volcanoes characterized by high-temperature fumarolic activity.
Gas production prediction and risk quantification of shale gas reservoirs in Sichuan Basin based on Gauss prediction model and Monte Carlo probability method
Authors: Li Haitao , Yu Guo , Fang Yizhu , Chen Yanru , Wang Chongyang , Zhang Dongming 
Published: August 2022

The shale gas exploration and development potential in the Sichuan Basin is huge. Production prediction and risk quantification are important in planning of natural gas resources. Hubbert and Gauss models are used to predict the growth trend of production in the gas reservoir. Based on the prediction results, the Monte Carlo simulation is used to calculate the probability of production realization. The evaluation matrix of risk level is established by using indices of production realization probability and dispersion degree for assessing the risk level of shale gas production. The results show that: 1) when URR is at the same growth rate, Gauss model has a more stable yield growth trend than Hubbert model, and the correlation coefficients of Gauss model are all higher than that of Hubbert model. This means that the production prediction results of the Gauss model have higher accuracy. 2) According to the Gauss model, the shale gas will reach peak production of (280–460) × 108 m3/a in 2042 and will have stable production from 2037 to 2047. By the end of the stable production stage, the URR exploitation degree is about 60%; 3) The Monte Carlo method can be used to obtain the production realization probability for each year. The risk level evaluation matrix can be established by taking the probability of realization and the dispersion degree as evaluation indices, which can provide the systematization of the risk levels. This study is helpful to deepen the understanding of natural gas exploration and development. And it is of great significance to gas field development planning and production index realization.
Satellite observations reveal decreasing soil erosion in Northeast Inner Mongolia, China, over the past four decades
Authors: Jiang Wei , Pang Zhiguo , Lv Juan , Ju Hongrun , Li Lin , Fu June 
Published: August 2022

Knowledge regarding the soil erosion change patterns in Northeast Inner Mongolia (NIM) is essential for ecological security and sustainable development. Multisource satellite remote sensing with auxiliary data, including meteorology, land use, vegetation coverage, and digital elevation, was collected to establish a distributed soil erosion model to quantify the soil erosion intensity in Northeast Inner Mongolia. The results showed that soil erosion in Northeast Inner Mongolia, China, decreased by 100,654 km2 from 1978 to 2018. The area change rates of the mild, moderate, strong, intensive and severe soil erosion intensities were −48.91%, −41.41%, 32.63%, −91.15%, and −91.14%, respectively. The decrease in soil erosion was mainly located in the Hulunbuir and Tongliao regions. Our findings from satellite observations provide information about the soil erosion intensity and spatial distribution required for policy-making and the management of soil erosion prevention in Northeast Inner Mongolia.
Severity of Nonalcoholic Fatty Liver Disease is Associated With Cardiovascular Outcomes in Patients With Prehypertension or Hypertension: A Community–Based Cohort Study
Authors: Song Qi–Rui , Liu Shuo–Lin , Ling Qian-Hui , Gao Qian-Nan , Yang Rui-Xue , Chen Shuo-Hua , Wu Shou–Ling , Chen Mu-Lei , Cai Jun 
Published: August 2022

BackgroundIt is unclear whether more severe non–alcoholic fatty liver disease (NAFLD) combined with prehypertension or hypertension is associated with a higher risk of cardiovascular events (CVEs). To evaluate the relationship between the severity of NAFLD and CVEs among patients with prehypertension or hypertension.MethodsIn this prospective community–based Kailuan cohort, participants without cardiovascular disease and alcohol abuse, or other liver diseases were enrolled. NAFLD was diagnosed by abdominal ultrasonography. Prehypertension was defined as systolic blood pressure (BP) of 120–139 mmHg or diastolic BP of 80–89 mmHg. Participants with NAFLD were divided into mild, moderate, and severe subgroups. Follow–up for CVEs including myocardial infarction, hemorrhagic stroke, and ischemic stroke. The Cox proportional hazards model was used to estimate hazard ratios and 95% CIs of CVEs according to the severity of NAFLD and hypertensive statutes. The C-statistic was used to evaluate the efficiency of models.ResultsA total of 71926 participants (mean [SD] age, 51.83 [12.72] years, 53794 [74.79%] men, and 18132 [25.21%] women) were enrolled in this study, 6,045 CVEs occurred during a median of 13.02 (0.65) years of follow–up. Compared with participants without NAFLD, the hazard ratios of CVEs for patients with mild, moderate, and severe NAFLD were 1.143 (95% CI 1.071–1.221, P &lt; 0.001), 1.218 (95% CI 1.071–1.221, P &lt; 0.001), and 1.367 (95% CI 1.172–1.595, P &lt; 0.001), respectively. Moreover, participants with prehypertension plus moderate/severe NAFLD and those with hypertension plus moderate/severe NAFLD had 1.558–fold (95% CI 1.293–1.877, P &lt; 0.001) and 2.357–fold (95% CI 2.063–2.691, P &lt; 0.001) higher risks of CVEs, respectively, compared with those with normal BP and no NAFLD. Adding a combination of NAFLD and BP status to the crude Cox model increased the C–statistic by 0.0130 (0.0115–0.0158, P &lt; 0.001).ConclusionsOur findings indicated that the increased cardiovascular risk with elevated BP is largely driven by the coexistence of moderate/severe NAFLD, suggesting that the severity of NAFLD may help further stratify patients with prehypertension and hypertension.
Tumor size is an independent negative prognostic factor for event free survival in children with differentiated thyroid cancer
Authors: Parvathareddy Sandeep Kumar , Siraj Abdul K. , Annaiyappanaidu Padmanaban , Siraj Nabil , Haqawi Wael , Al-Sobhi Saif S. , Al-Dayel Fouad , Al-Kuraya Khawla S. 
Published: August 2022

BackgroundThe incidence of pediatric differentiated thyroid carcinoma (DTC) is increasing. Despite the advanced disease at presentation, the overall prognosis of DTC in children is excellent. The aim of this study is to investigate the risk stratifying factors for event free survival (EFS) of pediatric DTC from Middle Eastern ethnicity.MethodsEighty-eight patients aged ≤18 years with diagnosis of primary DTC were retrospectively analyzed. Cox proportional hazards model were used to calculate Hazard Ratios (HR) and Kaplan–Meier analysis were conducted to investigate EFS.ResultsEighty-eight (23 males and 65 females) pediatric DTCs who underwent surgery and radioactive iodine therapy had been reported (median age at diagnosis 15 years; range 5.9-17.9), with lymph node metastasis (LNM) noted in 70.5% and distant metastasis in 13.6%. Mean follow-up was 8.4 years. Ten-year overall survival rate was 98.4% while 10-year EFS was 79.2%. EFS was negatively impacted by the presence of LNM, distant metastasis and tumor size &gt;4cm. American Thyroid Association risk stratification did not impact EFS in our cohort. Multivariate analysis revealed tumor size &gt;4cm (HR = 5.34; 95% confidence interval (CI) = 1.36 – 20.22; p = 0.0177) and distant metastasis (HR = 8.73; 95% CI = 1.48 – 60.05; p = 0.0154) as independent negative prognostic factors for EFS.ConclusionsPrimary tumor size and the presence of distant metastasis at diagnosis are the only independent prognostic risk factors for EFS in pediatric DTC in Middle Eastern ethnicity. Children with tumor size over 4cm had poor EFS, which may justify the need of more aggressive treatment and frequent follow-up.
Green electricity generation from biogas of cattle manure: An assessment of potential and feasibility in Pakistan
Authors: Arshad Muhammad , Ansari Abdur Rahman , Qadir Rahman , Tahir Mudassir Hussain , Nadeem Ans , Mehmood Tahir , Alhumade Hesham , Khan Nasrullah 
Published: August 2022

In several countries, organic or municipal solid wastes, such as cattle and buffalo manure, have become a serious political and environmental issue owing to organic waste incineration and garbage disposal. To overcome this problem, biogas production from manure, a green treatment that both contributes to the availability of sustainable energy and assists in reducing global warming, was considered. The current study was conducted on the generation of green electricity using cattle and buffalo manure in Pakistan. In 2021, Pakistan has generated 102.742-terawatt hour (TWh) of electricity collectively; biogas share in total production accounted for only 0.98%, which is approximately 1 TWh. Unfortunately, most of the electricity was generated from nonrenewable energy sources. One large animal produces 9–10 kg of manure per day. A system for manure collection can be developed; 30% of total manure produced every day by cattle and buffalo can be collected. Such a type of system is already used for the collection of poultry manure. Pakistan has been blessed with almost 42.4 million buffaloes and 51.5 million cattle. The annual collection of manure from cattle and buffalo at the rate of 30% will be 92.53 million tons. From this manure, approximately 4.63 billion m3of biogas can be produced and 70% can be collected, which will be 3.24 billion m3. Thus, Pakistan has the potential of generating 19.79 TWh of electricity per day from cattle and buffalo manure. Biogas has the potential to generate over 20% of Pakistan’s total electricity. At the farm level, 100 cattle ranches with 60% collected manure can create roughly 57% of their total consumed electricity. Slurry, a byproduct of anaerobic digestion, can be used as a biofertilizer in fields. It is possible to use cattle manure to make biogas, which is “made by fermentation of organic waste in the absence of oxygen.” It aids in the reduction of fossil fuel dependency, solid waste management, and air pollution control by lowering greenhouse gas emissions. Biogas contributes to the three pillars of sustainable development: economic, environmental, and social development. Biogas contributes significantly to the SDGs and other aspects of sustainable development.
Identification of the pyroptosis-related prognostic gene signature and characterization of tumor microenvironment infiltration in triple-negative breast cancer
Authors: Liu Ji , Ma Jianli , Zhang Qingyuan 
Published: August 2022

Background: Triple-negative breast cancer remains a highly malignant disease due to the lack of specific targeted therapy and immunotherapy. A growing body of evidence supports the role of pyroptosis in tumorigenesis and prognosis, but further exploration is needed to improve our understanding of the tumor microenvironment in patients with triple-negative breast cancer.Methods: Consensus clustering analysis was performed to construct pattern clusters. A correlation analysis was conducted between the pattern clusters and the tumor microenvironment using GSVA, ESTIMATE, and CIBERSORT. Then, a risk score and a nomogram were constructed and verified to predict overall survival.Results: Two pyro-clusters and three pyro-gene clusters that differed significantly in terms of prognosis, biological processes, clinical features, and tumor microenvironment were identified. The different clusters corresponded to different immune expression profiles. The constructed risk score predicted patient prognosis and response to immunotherapy. Patients with low risk scores exhibited favorable outcomes with increased immune cell infiltration and expression of immune checkpoint molecules. Compared to other models, the nomogram was extremely effective in predicting prognosis.Conclusion: In the landscape of the immune microenvironment, pyroptosis-mediated pattern clusters differed markedly. Both the developed risk score and the nomogram were effective predictive models. These findings could help develop customized treatment for patients with triple-negative breast cancer.
Twelve exonic variants in the SLC12A1 and CLCNKB genes alter RNA splicing in a minigene assay
Authors: Xin Qing , Liu Qihua , Liu Zhiying , Shi Xiaomeng , Liu Xuyan , Zhang Ruixiao , Hong Yefeng , Zhao Xiangzhong , Shao Leping 
Published: August 2022

Background: Bartter syndrome (BS) is a rare renal tubular disease caused by gene variants in SLC12A1, KCNJ1, CLCNKA, CLCNKB, BSND or MAGED2 genes. There is growing evidence that many exonic mutations can affect the pre-mRNA normal splicing and induce exon skipping by altering various splicing regulatory signals. Therefore, the aim of this study was to gain new insights into the consequences of exonic mutations associated with BS on pre-mRNA splicing.Methods: We analyzed all the missense, nonsense and synonymous variants described in six pathogenic genes by bioinformatics programs and identified candidate mutations that may promote exon skipping through a minigene system.Results: Results of the study showed that 12 of 14 candidate variants distributed in SLC12A1 (c.728G&gt;A, C.735C&gt;G, c.904C&gt;T, c.905G&gt;A, c.1304C&gt;T, c.1493C&gt;T, c.2221A&gt;T) and CLCNKB (c.226C&gt;T, c.228A&gt;C, c.229G&gt;A, c.229G&gt;C, c.1979C&gt;A) were identified to induce splicing alterations. These variants may not only disrupt exonic splicing enhancers (ESEs) but also generate new exonic splicing silencers (ESSs), or disturb the classic splicing sites.Conclusion: To our knowledge, this is a comprehensive study regarding alterations in pre-mRNA of exonic variants in BS pathogenic genes. Our results reinforce the necessity of assessing the consequences of exonic variants at the mRNA level.
mHealth interventions to reduce maternal and child mortality in Sub-Saharan Africa and Southern Asia: A systematic literature review
Authors: Bossman Elvis , Johansen Monika A. , Zanaboni Paolo 
Published: August 2022

BackgroundReducing maternal mortality, neonatal mortality and under 5-year mortality are important targets addressed by the United Nations' Sustainable Development Goals. Despite studies reported an improvement in maternal and child health indicators, the progress achieved is not uniform across regions. Due to the increasing availability of mobile phones in low and middle-income countries, mHealth could impact considerably on reducing maternal and child mortality and maximizing women's access to quality care, from the antenatal stage to the post-natal period.MethodsA systematic literature review of mHealth interventions aimed at reducing maternal and child mortality in Sub-Saharan Africa and Southern Asia. Primary outcomes were maternal mortality, neonatal mortality, and under-five mortality. Secondary outcomes were skilled birth attendance, antenatal care (ANC) and post-natal care (PNC) attendance, and vaccination/immunization coverage. We searched for articles published from January 2010 to December 2020 in Embase, Medline and Web of Science. Quantitative comparative studies were included. The protocol was developed according to the PRISMA Checklist and published in PROSPERO [CRD42019109434]. The Quality Assessment Tool for Quantitative Studies was used to assess the quality of the eligible studies.Results23 studies were included in the review, 16 undertaken in Sub-Saharan Africa and 7 in Southern Asia. Most studies used SMS or voice message reminders for education purposes. Only two studies reported outcomes on neonatal mortality, with positive results. None of the studies reported results on maternal mortality or under-five mortality. Outcomes on skilled birth attendance, ANC attendance, PNC attendance, and vaccination coverage were reported in six, six, five, and eleven studies, respectively. Most of these studies showed a positive impact of mHealth interventions on the secondary outcomes.ConclusionSimple mHealth educational interventions based on SMS and voice message reminders are effective at supporting behavior change of pregnant women and training of health workers, thus improving ANC and PNC attendance, vaccination coverage and skilled birth attendance. Higher quality studies addressing the role of mHealth in reducing maternal and child mortality in resource-limited settings are needed, especially in Southern Asia.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019109434, identifier CRD42019109434.
Pulmonary infection and baseline mRS scores predict poor prognosis in anti-GABABR encephalitis
Authors: Ding Junqing , Xu Dingkang , Lv Jie , Wu Tianwen , Li Jinghong , Tian Mi , Lian Yajun 
Published: August 2022

PurposeAnti-gamma-aminobutyric-acid type B receptor (anti-GABABR) encephalitis is a rare autoimmune condition caused by the presence of GABABR antibodies in the limbic system. However, its clinical features and prognostic factors are poorly understood. In this study, we aimed to explore factors that affect the response to first-line treatment in patients with anti-GABABR encephalitis.MethodsThirty-four patients with an initial diagnosis of anti-GABABR encephalitis were retrospectively enrolled from December 2015 to June 2021. Clinical features and experimental data recorded within 24 h of admission were extracted from the patients’ medical records. The modified Rankin Scale (mRS) was utilized to assess disease severity at admission and functional recovery after immunotherapy. Independent prognostic factors were determined by ordinal logistic regression analysis.ResultsOf the 34 anti-GABABR encephalitis patients, 12 (35%) presented with cancer; all of these patients had lung cancer. According to multivariate regression analysis, the cancer group exhibited a decrease in the peripheral blood absolute lymphocyte count (ALC) (odds ratio [OR]: 0.063, 95% confidence interval [CI]: 0.006-0.639, P=0.019) and hyponatremia (OR: 9.268, 95% CI: 1.054-81.502, 0.045). In addition, the neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and platelet/lymphocyte ratio (PLR) did not significantly differ according to mRS scores in patients receiving first-line treatment. No patients with mild or moderate mRS scores (0-2) at admission developed symptoms after treatment; in contrast, only 11 patients with a severe mRS scores (≥3, 11/18) experienced symptom alleviation. Ordinal regression analysis indicated that worse prognosis was associated with pulmonary infection (OR=9.885, 95% CI: 1.106-88.323, P=0.040) and baseline mRS scores (OR= 24.047, 95% CI: 3.294-175.739, P=0.002) in the adjusted model.ConclusionOur findings demonstrate that pulmonary infection and baseline mRS scores are independent risk factors for poor prognosis in patients with anti-GABABR encephalitis after first-line treatment. ALC and hyponatremia are potential biomarkers for anti-GABABR encephalitis cases accompanied by lung cancer.