bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a thin-tipped short bevel needle for peripheral intravenous access on the compressive deformation and displacement of the vein: A preclinical study
Authors: Tanabe Hidenori , Oosawa Kousuke , Miura Manabu , Mizuno Shinichi , Yokota Takayuki , Ueda Takehiko , Zushi Yasunobu , Nagata Misako , Murayama Ryoko , Abe-Doi Mari , Sanada Hiromi 
Published: July 2022

Background: Peripheral intravenous catheter (PIVC) insertion often fails on the first attempt. Risk factors include small vein size and dehydration, causing vein deformation and displacement due to puncture resistance of the vessel. The authors developed a short, thin-tipped bevel needle and compared its puncture performance with needles of four available PIVCs using an ex vivo model. Methods: The PIVC with the thin-tipped short bevel needle was compared to four available PIVCs using an ex vivo model which simulated the cephalic vein of the human forearm. The ex vivo model consisted of a porcine shoulder and porcine internal jugular vein, and was used for evaluation of the rate of vein deformation and vessel displacement during needle insertion. Results: An ex vivo model was created with a vessel diameter of 2.7–3.7 mm and a depth of 2–5 mm. The thin-tipped short bevel PIVC needle was associated with a significantly lower compressive deformation rate and venous displacement compared to the needles of the other four PIVCs. Conclusion: The thin-tipped short bevel needle induced lower compressive deformation and displacement of the vein than the conventional needles. This needle has the potential to improve the first-attempt success rate of peripheral intravenous catheterization in patients with difficult venous access.
Virtual sedation as a substitute to pharmacological sedation during PICC placement in pediatric patients: A feasibility study
Authors: Sanna Gianuario , Camporesi Anna , Diotto Veronica , Abbiati Giacomo , Torri Adriano , Gemma Marco 
Published: July 2022

Introduction: In pediatric patients, PICC insertion is often performed under sedation to reduce pain and anxiety, which is associated with risks such as laryngospasm, apnea, and hypoxia. Furthermore, it requires a pediatric anesthesiologist. The aim of our study was to evaluate the VR as an alternative to pharmacological sedation to reduce those risks and the overall cost. Methods: We tested a VR immersive experience for ten children requiring a PICC. To achieve this, we ran a software, specifically designed for the pediatric healthcare setting, on a commercially available VR headset. In order to evaluate this new practice, we recorded the following data: Patient’s anxiety before and after the procedure, recorded through a modified numeric rating scale from 0 (no anxiety) to 10 (worst anxiety imaginable). Patient’s pain before (e.g., because of preexisting medical conditions) and after the procedure through a Wong-Baker scale. Caregiver’s satisfaction. No active or passive restraint was enforced during the whole procedure, patients had to keep their arms still all by themselves. Result: Out of the 10 patients only in a single case, we had to interrupt the attempt with the VR technique and let the anesthesiologist perform a sedation. From the immediate beginning said patient had trouble adapting to the virtual environment and tried to remove the headset. In all other cases, we noticed a drop in the anxiety level of the patient and the pain never increased. Globally, caregivers were pleased with the experience and reported an average satisfaction rate of 9.3 out of 10. Conclusion: Virtual reality seems a valid alternative to traditional sedation in pediatric patients undergoing a PICC placement procedure. Additional studies, with adequate sample size, of patients are necessary to assess the benefit from this new approach, as well as its impact on the overall procedure length.
Long-term results of autologous scaffold-free tissue-engineered vascular graft for hemodialysis access
Authors: Wystrychowski Wojciech , Garrido Sergio A , Marini Alicia , Dusserre Nathalie , Radochonski Sam , Zagalski Krzysztof , Antonelli Jorge , Canalis Manuel , Sammartino Andrea , Darocha Zbigniew , Baczyński Ryszard , Cierniak Tomasz , Regele Heinz , de la Fuente Luis M , Cierpka Lech , McAllister Todd N , L’Heureux Nicolas 
Published: July 2022

Background: The growing size of the end stage renal disease (ESRD) population highlights the need for effective dialysis access. Exhausted native vascular access options have led to increased use of catheters and prosthetic shunts, which are both associated with high risks of access failure and infection. Emerging alternatives include tissue-engineered vascular grafts (TEVG). Here we present the endpoint results for 10 ESRD patients with the scaffold-free tissue-engineered vascular access produced from sheets of extracellular matrix produced in vitro by human cells in culture. Methods: Grafts were implanted as arteriovenous shunts in 10 ESRD patients with a complex history of access failure. Follow-up included ultrasound control of graft morphology and function, dialysis efficiency, access failure, intervention rate, as well as immunohistochemical analysis of graft structure. Results: One patient died of unrelated causes and three shunts failed to become useable access grafts during the 3-month maturation phase. The 12-month primary and secondary patency for the other six shunts was 86%. Survival of six shunts functioning as the vascular access was 22 ± 12 months with longest primary patency of 38.6 months. The dialysis event rate of 3.34 per patient-year decreased significantly with the use of this TEVG to 0.67. Conclusions: This living autologous tissue-engineered vascular graft seems to be an alternative to synthetic vascular access options, exhibiting advantages of native arteriovenous fistula.
Determination of Tetracycline Residues in Kidney and Muscle of Beef Cattle Slaughtered in Dire Dawa and Harar Municipal Abattoirs, Eastern Ethiopia
Authors: Mohammed Nuredin , Adare Mengistu Dechasa , Abdurehman Abdallahi , Belina Dinaol , Mengistu Shimelis 
Published: July 2022

Background: Antibiotics are among the most widely used drugs in farm animals for therapeutic and prophylactic purposes. However, the antibiotic residues in meat are a serious public health concern due to their harmful effects on consumer health. Besides this problem, there is limited information on the level of the antibiotic residues, including tetracycline residues. Therefore, this study was aimed to determine the tetracycline residues in the kidney and muscle samples of beef cattle in Harar town and Dire Dawa city. Methods: A study was conducted on 500 randomly selected carcass (250 kidney and 250 muscle samples) slaughtered at Dire Dawa and Harar municipal slaughterhouses between December 2018 and December 2019. The samples were collected aseptically and screened for tetracycline residues by thin layer chromatography. Then, presumptive positive samples were analyzed using high-performance liquid chromatography to get a quantitative outcome. Descriptive statistics were used to determine the frequency, mean, or standard deviation to determine the summary values and distribution of the outcomes. Finally, the data was analyzed using SPSS version 21 software. Results: Out of 500 samples, oxytetracycline residues were detected in 84% of the samples. However, tetracycline and doxycycline were not detected in all samples. Among the kidney and muscle samples collected from Dire Dawa and Harar abattoirs, 109 (87.2%) and 101 (80.8%) were positive for oxytetracycline, respectively. Oxytetracycline residue levels in Dire Dawa ranged from 57 to 607 µg/kg for the kidney and 10.14 to 435 µg/kg for muscle samples. Among the samples collected from Harar, the concentration of oxytetracycline residues ranged from 16 to 433 µg/kg and 6 to 435 µg/kg for kidney and muscle samples, respectively, at Harar slaughterhouses. About 22.0% of muscle samples collected from Dire Dawa and 17.8% from Harar town had oxytetracycline residues above maximum residue limits. Conclusions: In general, the study revealed that oxytetracycline residues were prevalent among tetracycline residues analyzed from kidney and muscle samples in the study areas. Thus, there is a risk of consumer exposure to these antibiotic residues that may have human health effects. Therefore, awareness creation and strict regulation is needed by the regulatory authorities for the use of antimicrobial drugs in the livestock industry.
Electronic Vapor Product Use and Levels of Physical Activity Among High School Students in Georgia
Authors: Rajbhandari-Thapa Janani , Thapa Kiran , Li Yan , Ingels Justin B. , Shi Lu , Zhang Donglan , Shen Ye , Chiang Kathryn 
Published: July 2022

Introduction Using a cross-sectional population-based survey, electronic vapor product (EVP) use was evaluated in relation to physical activity levels among high school students in Georgia. Methods We used self-reported EVP and cigarette use from the Georgia Student Health Survey 2.0 data from 2018 (N =362 933) and used multi-level multinomial logistic regression models to estimate relative risks of the type of product use relative to no-use by levels of physical activity. Results Nearly 7% of the students were EVP-only users. The relative risks of being an EVP-only user were 11% and 23% higher for those who were physically active 2-3 days/week and 4-5 days/week, respectively, compared to those who were physically active <=1 day/week. Conclusions Being physically active was positively associated with EVP use among adolescents. Health promotion education and health policies should be developed as a means of reducing EVP use among adolescents.
Volume and Variability of Foot and Ankle Case Exposure During Orthopaedic Residency: 2014-2019
Authors: Hartnett Davis A. , Lama Christopher J. , Garcia-Lopez Edgar , Daniels Alan H. , Richardson David R. 
Published: July 2022

Background: Exposure to a comprehensive breadth and volume of surgical cases is a fundamental component of orthopaedic education, though standardization of case exposures across residency programs is limited to a small amount of required case minimums. Significant variability in exposure to subspecialty cases, such as foot and ankle surgeries, can create distinctly different residency experiences. Methods: Accreditation Council for Graduate Medical Education (ACGME) surgical case logs from 2014 to 2019 for leg/ankle and foot/toes were examined following the 2013 implementation of case minimums. Average surgical case volume across subcategories and the average volume of different residency percentiles were analyzed to assess variability. Results: The mean total volume of case exposure for graduating orthopaedic residents has increased significantly since 2014 for both leg/ankle cases (28.6%) and foot/toes (27.8%), though totals were still down compared with when ACGME reporting began in 2007. Arthrodesis exposures have increased significantly for leg/ankle (69.2%) and foot/toes (93.8%) cases since 2014, and ankle arthroscopy has increased 20.7%. Disparities in total cases between 10th and 90th percentile programs have shown a nonsignificant decrease over time, with significant differences between leg/ankle arthrodesis (8-fold), leg/ankle arthroscopy (13-fold), and foot/toe arthrodesis (3.5-fold) in 2019. Conclusion: The mean volume of foot and ankle case exposures among graduating residents has continued to rise since the implementation of case minimums in 2013 but disparities in volume are present, most notably concerning arthrodesis and arthroscopy. Recognition and future attention toward addressing this variability can be meaningful in promoting a more comprehensive, standardized orthopaedics education. Level of Evidence: Level III: Retrospective comparative study.
Advancing understanding of dietary and movement behaviours in an Asian population through real-time monitoring: Protocol of the Continuous Observations of Behavioural Risk Factors in Asia study (COBRA)
Authors: Edney Sarah Martine , Park Su Hyun , Tan Linda , Chua Xin Hui , Dickens Borame Sue Lee , Rebello Salome A , Petrunoff Nick , Müller Andre Matthias , Tan Chuen Seng , Müller-Riemenschneider Falk , van Dam Rob M 
Published: July 2022

Background Modifiable risk factors for non-communicable diseases, including eating an unhealthy diet and being physically inactive, are influenced by complex and dynamic interactions between people and their social and physical environment. Therefore, understanding patterns and determinants of these risk factors as they occur in real life is essential to enable the design of precision public health interventions. Objective This paper describes the protocol for the Continuous Observations of Behavioural Risk Factors in Asia study (COBRA). The study uses real-time data capture methods to gain a comprehensive understanding of eating and movement behaviours, including how these differ by socio-demographic characteristics and are shaped by people's interaction with their social and physical environment. Methods COBRA is an observational study in free-living conditions. We will recruit 1500 adults aged 21–69 years from a large prospective cohort study. Real-time data capture methods will be used for nine consecutive days: an ecological momentary assessment app with a global positioning system enabled to collect location data, accelerometers to measure movement, and wearable sensors to monitor blood glucose levels. Participants receive six EMA surveys per day between 8 a.m. and 9.30 p.m. to capture information on behavioural risk factors including eating behaviours and diet composition movement behaviours (physical activity, sedentary behaviour, sleep), and related contextual factors. The second wave of ecological momentary assessment surveys with a global positioning system enabled will be sent 6 months later. Data will be analysed using generalised linear models to examine associations between behavioural risk factors and contextual determinants. Discussion Findings from this study will advance our understanding of dietary and movement behaviours as they occur in real-life and inform the development of personalised interventions to prevent chronic diseases.
Mixed epithelial and stromal tumor of the kidney composed mainly of solid components: A case report
Authors: Maeba Kiyoka , Kanki Akihiko , Watanabe Hiroyuki , Yamamoto Akira , Fujimoto Yasuto , Yoshiyuki Miyaji , Tamada Tsutomu 
Published: July 2022

Mixed epithelial and stromal tumor (MEST) is a relatively rare lesion of mixed epithelial and mesenchymal origin, consisting of epithelial components that form cysts and stromal cells that are positive for estrogen and progesterone receptors. The present case was a 54-year-old female who presented with hematuria. Abdominal ultrasonography revealed a 41 x 30 mm tumor in the right kidney, with the tumor protruding outward in the direction of the renal pelvis. Dynamic contrast-enhanced computed tomography and magnetic resonance imaging confirmed a solid tumor in the right kidney that showed gradual contrast enhancement and contained a central non-enhancing area with the appearance of a cystic component. Based on the imaging findings, the provisional diagnosis was papillary renal cell carcinoma or angiomyolipoma with epithelial cysts. Right nephrectomy was performed and the tumor was confirmed histopathologically as MEST. We report a very rare case of MEST that was composed mainly of solid components.
Combination of laparoscopic side-to-end colorectal anastomosis and vaginal nose (natural orifice specimen extraction) surgery for colorectal endometriosis: Technique and outcomes
Authors: Kale Ahmet , Kuru Betul , Baydili Kursat Nuri , Cokay Deniz , Basol Gulfem , Cansu Gundogdu Elif , Mat Emre , Ertugrul Ismail , Altuntas Yunus Emre , Usta Taner , Aboalhasan Yasmin , Oral Engin 
Published: July 2022

Objective: To investigate the effectiveness of combining side-to-end anastomosis and vaginal NOSE (Natural orifice specimen extraction) surgery in colorectal endometriosis. Material and methods: We included 11 patients treated with laparoscopic side-to-end colorectal anastomosis and vaginal NOSE surgery between January 2019 and May 2021. We questioned the visual analog score (VAS) for pain symptoms, the short form-36 (SF-36) for health survey questionnaire, The Female Sexual Function Index (FSFI), EHP-5 for endometriosis health profile, The Hospital Anxiety and Depression Scale (HADS), OAB-V8 for overactive bladder symptoms and Constipation Severity Instrument (CSI). Results: VAS, EHP-5, and SF-36 scores were better at postoperative third and sixth months than preoperative values ( p < 0.05). There were no statistically significant differences in terms of FSFI, OAB-V8, HADS, and the CSI. Conclusions: Laparoscopic side-to-end anastomosis with vaginal NOSE surgery is feasible, scarless, and could be offered to patients with deep symptomatic bowel endometriosis.
Removal of ivermectin from aqueous media using commercial, bentonite-based organophilic clay as an adsorbent
Authors: Nippes Ramiro Picoli , Macruz Paula Derksen , Coslop Thaísa Frossard , Molinari Deise , Scaliante Mara Heloísa Neves Olsen 
Published: July 2022

AbstractThe worldwide use of pharmaceuticals is of concern to those researchers who develop new techniques for the removal of these compounds from the aquatic medium. The objective of the present work was to characterize and evaluate the performance of a commercial, bentonite-based organophilic clay in removing ivermectin from aqueous solution. The adsorbent was characterized by nitrogen physisorption, thermogravimetric-differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Batch-scale adsorption experiments were performed to evaluate the kinetics, isotherms, thermodynamics and effect of pH on removal of this drug and reuse of the clay. The bentonite has a small specific surface area with an irregular surface. The Elovich kinetic model fits the experimental data better than other models, indicating that chemisorption contributes to drug removal in this case. The Langmuir and Sips isothermal models best fit the experimental equilibrium data. The process was shown to be favorable (ΔG°ads<0), endothermic (ΔH°ads>0), with an increase in the degrees of freedom at the solid–liquid interface (ΔS°ads>0), and with characteristics of a physical-chemical adsorption process (Ea = 11.065 kJ mol–1) under the study conditions. Adsorption was favored at the natural pH of the solution and the organophilic clay could be regenerated with water and reused in consecutive adsorption cycles. The amount of ivermectin adsorbed on the organophilic clay ranged from 1.78 to 3.88 mg g–1. The organophilic clay was shown to be a cost-effective potential adsorbent for ivermectin-contaminated water-treatment applications.
The crystal structure of Pd8As3, a synthetic analogue of stillwaterite
Authors: Karimova Oxana V. , Mezhueva Anna A. , Zgurskiy Nikolay A. , Zolotarev Andrey A. , Chareev Dmitriy A. 
Published: July 2022

AbstractThe synthetic analogue of mineral stillwaterite, Pd8As3, was synthesised and its crystal structure was solved to R1 = 0.0341 based on single crystal X-ray diffraction data. Pd8As3 is trigonal and the space group is P$\bar{3}$. The unit-cell parameters are a = 7.4261(4), c = 10.3097(9) Å and V = 492.38(7) Å3 with Z = 3. The structure builds up by layers of Pd and As atoms. Pd-nets and As-nets are parallel to (110) and stack along the c axis direction. The stacking sequence is ABCDEEDCBA. The relation between structures of minerals with the common formula Pd8T3 (T = As or/and Sb) are discussed. They are formed by nets of pnictogen and palladium atoms. The common feature of the structures is 36 topology of pnictogen nets. The differences are stacking sequences and topology of the palladium nets.
How I treat and prevent COVID-19 in patients with hematologic malignancies and recipients of cellular therapies
Authors: El Chaer Firas , Auletta Jeffery J. , Chemaly Roy F. 
Published: July 2022

Abstract
Patients with hematologic malignancies and recipients of hematopoietic cell transplantation (HCT) are more likely to experience severe coronavirus disease 2019 (COVID-19) and have a higher risk of morbidity and mortality after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Compared with the general population, these patients have suboptimal humoral responses to COVID-19 vaccines and subsequently increased risk for breakthrough infections, underscoring the need for additional therapies, including pre- and postexposure prophylaxis, to attenuate clinical progression to severe COVID-19. Therapies for COVID-19 are mostly available for adults and in the inpatient and outpatient settings. Selection and administration of the best treatment options are based on host factors; virus factors, including circulating SARS-CoV-2 variants; and therapeutic considerations, including the clinical efficacy, availability, and practicality of treatment and its associated side effects, including drug-drug interactions. In this paper, we discuss how we approach managing COVID-19 in patients with hematologic malignancies and recipients of HCT and cell therapy.
Airway autoantibodies are determinants of asthma severity
Authors: Salter Brittany , Zhao Nan , Son Kiho , Tan Nadia Suray , Dvorkin-Gheva Anna , Radford Katherine , LaVigne Nicola , Huang Chynna , Kjarsgaard Melanie , Li Quan-Zhen , Tselios Konstantinos , Lim Hui Fang , Khalidi Nader , Nair Parameswaran , Mukherjee Manali 
Published: July 2022

BackgroundLocal airway autoimmune responses may contribute to steroid dependence and persistent eosinophilia in severe asthma. Auto-IgG antibodies directed against granule proteins such as eosinophil peroxidase (EPX), macrophage scavenger receptor with collagenous structure (MARCO) and nuclear/extranuclear antigens (antinuclear antibodies (ANAs)) have been reported. Our objective was to describe the prevalence and clinical characteristics of asthmatic patients with airway autoreactivity, and to assess if this could be predicted from clinical history of autoreactivity.MethodsWe analysed anti-EPX, anti-MARCO and ANAs in 218 sputum samples collected prospectively from 148 asthmatic patients, and evaluated their association with lung function parameters, blood/airway inflammation, severity indices and exacerbations. Additionally, 107 of these patients consented to fill out an autoimmune checklist to determine personal/family history of systemic autoimmune disease and symptoms.ResultsOut of the 148 patients, 59 (40%) were anti-EPX IgG+, 53 (36%) were anti-MARCO IgG+and 64 out of 129 (50%) had ≥2 nuclear/extranuclear autoreactivities. A composite airway autoreactivity score (CAAS) demonstrated that 82 patients (55%) had ≥2 airway autoreactivities (considered as CAAS+). Increased airway eosinophil degranulation (OR 15.1, 95% CI 1.1–199.4), increased blood leukocytes (OR 3.5, 95% CI 1.3–10.1) and reduced blood lymphocytes (OR 0.19, 95% CI 0.04–0.84) predicted CAAS+. A third of CAAS+patients reported an exacerbation, associated with increased anti-EPX and/or anti-MARCO IgG (p<0.05). While no association was found between family history or personal diagnosis of autoimmune disease, 30% of CAAS+asthmatic patients reported sicca symptoms (p=0.02). Current anti-inflammatory (inhaled/oral corticosteroids and/or adjunct anti-interleukin-5 biologics) treatment does not attenuate airway autoantibodies, irrespective of eosinophil suppression.ConclusionWe report 55% of moderate–severe asthmatic patients to have airway autoreactivity that persists despite anti-inflammatory treatment and is associated with exacerbations.