bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
Authors: Brichko Rostislav , Soldan Anja , Zhu Yuxin , Wang Mei-Cheng , Faria Andreia , Albert Marilyn , Pettigrew Corinne ,   The BIOCARD Research Team
Published: June 2022

ObjectiveThis study examined the association of lifetime experiences, measured by a cognitive reserve (CR) composite score composed of years of education, literacy, and vocabulary measures, to level and rate of change in white matter microstructure, as assessed by diffusion tensor imaging (DTI) measures. We also examined whether the relationship between the proxy CR composite score and white matter microstructure was modified by participant age, APOE-ε4 genetic status, and level of vascular risk.MethodsA sample of 192 non-demented (n = 166 cognitively normal, n = 26 mild cognitive impairment) older adults [mean age = 70.17 (SD = 8.5) years] from the BIOCARD study underwent longitudinal DTI (mean follow-up = 2.5 years, max = 4.7 years). White matter microstructure was quantified by fractional anisotropy (FA) and radial diffusivity (RD) values in global white matter tracts and medial temporal lobe (MTL) white matter tracts.ResultsUsing longitudinal linear mixed effect models, we found that FA decreased over time and RD increased over time in both the global and MTL DTI composites, but the rate of change in these DTI measures was not related to level of CR. However, there were significant interactions between the CR composite score and age for global RD in the full sample, and for global FA, global RD, and MTL RD among those with normal cognition. These interactions indicated that among participants with a lower baseline age, higher CR composite scores were associated with higher FA and lower RD values, while among participants with higher age at baseline, higher CR composite scores were associated with lower FA and higher RD values. Furthermore, these relationships were not modified by APOE-ε4 genotype or level of vascular risk.ConclusionThe association between level of CR and DTI measures differs by age, suggesting a possible neuroprotective effect of CR among late middle-aged adults that shifts to a compensatory effect among older adults.
Patient Expectation in China: Exploring Patient Satisfaction in Online and Offline Patient–Provider Communication
Authors: Cao Bolin , Wang Dongya , Wang Yifan , Hall Brian J. 
Published: June 2022

IntroductionOnline patient–provider communication (OPPC) has become an alternative approach to seek medical advice and contact health professionals. However, its penetration rate remains low, and the underlying mechanisms of patient satisfaction with OPPC are underexamined. This study investigates the role of patient expectancy and the expectancy violation of patient-centered communication (PCC) in patient satisfaction in emerging OPPC scenarios by integrating the concepts of PCC and expectancy violation theory (EVT).MethodAn online survey was conducted in October 2019 among Chinese respondents who experienced OPPC and offline medical services.ResultsThe 471 qualified participants reported high satisfaction with OPPC (mean [M] = 3.63, standard deviation [SD] = 0.81). However, patient satisfaction with OPPC was lower than that in offline medical encounters (M = 3.75, SD = 0.80), and patients suffered a higher expectancy violation of PCC in OPPC scenarios (M = 0.45, SD = 0.76) than in offline medical encounters (M = 0.27, SD = 0.69). Nevertheless, patients’ satisfaction with OPPC significantly increased as the frequency of OPPC usage increased (β = 0.209, p &lt; 0.001). This positive relationship was partially mediated by the decrease in the expectancy violation of PCC in OPPC scenarios.DiscussionThe study can contribute to increasing the adoption of OPPC and reducing the burden of offline medical resources.
Socio-Economic Development and Mental Health: Case Study of the Spanish Region of Aragon (2010–20)
Authors: Bentué-Martínez Carmen , Rodrigues Marcos , García-Foncillas López Rafael , Llorente González José María , Zúñiga-Antón María 
Published: June 2022

IntroductionConsidering health as a cross-cutting element of all public policies leads to rethinking its interactions with the environment in which people live. The collection of large volumes of data by public administrations offers the opportunity to monitor and analyze the possible associations between health and territory. The increase in the incidence and prevalence of mental health diseases, particularly depression, justifies the need to develop studies that seek to identify links with the socioeconomic and environmental setting.ObjectiveThe objective of this study is to explain the behavior of the depression in a mediterranean region of Northeastern Spain from an ecological and diachronic perspective.MethodsWe conducted a correlation and multivariate logistic regression analysis to identify explanatory factors of the prevalence of depression in 2010 and 2020 and in the variation rate. Potential explanatory factors are related to the socioeconomic status and to the territorial development level.ResultsThe regression models retained both socioeconomic and territorial development variables as predictors of the prevalence in both years and in the variation rate. Rural areas seem to play a protective role against the prevalence.ConclusionIt is under the territorial prism that epidemiological studies could offer useful guidelines for proactive decision-making. The integration of data on diseases and territory must be considered when developing policies for the creation of healthier environments and for directing health services with more specific resources to where they may be needed.
Cognitive Impairment and Psychopathology Are Related to Plasma Oxidative Stress in Long Term Hospitalized Patients With Chronic Schizophrenia
Authors: Yang Man , Li Jin , Yang Haidong , Yan Linya , Liu Dongliang , Zhu Lin , Zhang Xiaobin 
Published: June 2022

BackgroundThe present study aimed to examine whether plasma oxidative stress is associated with cognitive impairment in long term hospitalized patients with chronic schizophrenia.MethodNinety-six chronic schizophrenia patients and 94 healthy unaffected subjects were enrolled. Plasma markers of oxidative stress, including malondialdehyde (MDA), manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GSH-Px), were measured. Psychiatric symptoms and cognitive function were assessed with the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), respectively.ResultsPlasma MDA levels and MnSOD and GSH-Px activities were significantly lower in schizophrenia patients than in healthy controls (P &lt; 0.001), while plasma CAT activity was higher than in healthy controls (P &lt; 0.005). Cognitive scores on the RBANS and all of its five subscales (all P &lt; 0.001) were significantly lower in schizophrenia patients than in healthy unaffected subjects. CAT and GSH-Px activities were positively correlated with the cognitive function scores corresponding to Visuospatial/Constructional abilities in the patient group (r = 0.298, 0.213, respectively, P &lt; 0.05). Also, the multiple regression analysis revealed that CAT and GSH-Px activities were independent and separate contributors to the Visuospatial/Constructional index of the RBANS. Meanwhile, CAT activity was negatively correlated with general pathological symptoms (r = −0.307, Bonferroni corrected P = 0.008) and the total score of the PANSS domains (r = −0.299, Bonferroni corrected P = 0.012).ConclusionOur results that the reduced of MDA level and the increased CAT activity in plasma in male patients with chronic schizophrenia suggest that redox imbalance may be associated with the pathophysiology of schizophrenia, and it can induce impaired cognition and psychiatric symptoms.
Association Between Intergenerational Support, Social Integration, and Subjective Well-Being Among Migrant Elderly Following Children in Jinan, China
Authors: Jia Qingchen , Li Shixue , Kong Fanlei 
Published: June 2022

BackgroundIn China, as domestic urbanization progresses and immigration expands, an increasing number of older people are choosing to follow their migrant children to new cities. Such people are referred to as “migrant elderly following children.” However, few studies have explored the subjective well-being of these older adults. The present study aims to investigate the factors that influence the subjective well-being of this population of older adults.MethodsThis cross-sectional study was conducted among 656 older migrants who had followed their children to Jinan, Shandong Province, China. Multistage cluster random sampling was used. Binary logistic regression analyses were performed to explore, the relationships between intergenerational support, social integration, and subjective well-being.ResultsOverall, 96.3% of the older migrants showed good subjective well-being. Analysis of intergenerational support showed that those who had a female child (odds ratio [OR] = 0.401, 95% confidence interval [95%CI]: 0.180, 0.893) and those whose children had terrible conjugal relationships (OR = 0.223, 95% CI: 0.099, 0.504) were less likely to have better subjective well-being. Analysis of social integration showed that migrants who liked their current city (OR = 5.358, 95%CI: 1. 631, 17.599) and those who had a basic understanding of the local dialect (OR = 2.869, 95%CI: 1.203, 6.843) were more likely to have good subjective well-being. Migrants who had used in-patient service in the past year (OR = 0.216, 95%CI: 0.094, 0.497) were more likely to have poor subjective well-being.ConclusionIntergenerational support and social integration are positively associated with the subjective well-being of migrant elderly following children in China. Efforts should be made, including the creation of specialized policies, to improve the family atmosphere of such migrants and their integration into their new cities, as this would contribute to improving their subjective well-being.
Can Self-Regulatory Strength Training Counter Prior Mental Exertion? A Systematic Review of Randomized Controlled Trials
Authors: Sun He , Soh Kim Geok , Norjali Wazir Mohd Rozilee Wazir , Ding Cong , Xu Tingting , Zhang Dong 
Published: June 2022

BackgroundPrior mental exertion consumes self-regulation and influences any subsequent physical or cognitive performance according to the strength model of self-regulation. However, the counteractive effect of self-regulatory strength training remains unclear.ObjectiveThis study aims to report a comprehensive systematic review investigating self-regulatory strength training programmes on physical or cognitive performance.MethodsTo select relevant studies from the available literature, a thorough search was conducted on PubMed, Web of Science, EBSCOhost (CENTRAL, Psychology and Behavioral Sciences Collection, SPORTDicus), Scopus, and Google Scholar, as well as the sources of reference for gray literature. Only randomized controlled trials involving healthy humans, strength-based self-regulation training programmes with comparable protocols, and a physical or cognitive task associated with the study were selected for the current review. The Grading of Recommendations Assessment Development and Evaluation (GRADE) framework was used to develop the summary of findings.ResultsTwelve articles were included based on the selection criteria. Evidence certainty for outcomes was graded as either low or very low level. The majority of the studies reported that self-regulatory strength training programmes can significantly counter prior mental exertion and decrement of performance, while only one study did not find such improvement. According to the strength model, a period of training increased the ‘self-regulatory muscle.'ConclusionStrength is an important ingredient in the resource model of self-regulation and can be trained to counter prior mental exertion and improve subsequent physical and cognitive performance. The training effects are cross-domain (e.g., emotional and cognitive domains; higher and lower levels of executive functions). However, motivation plays a key role to mobilize this resource. Future studies should examine the mechanism that underlies the strength.Systematic Review Registrationhttps://inplasy.com/inplasy-2022-1-0060/, identifier: INPLASY202210060.
Educational Automatic Question Generation Improves Reading Comprehension in Non-native Speakers: A Learner-Centric Case Study
Authors: Steuer Tim , Filighera Anna , Tregel Thomas , Miede André 
Published: June 2022

BackgroundAsking learners manually authored questions about their readings improves their text comprehension. Yet, not all reading materials comprise sufficiently many questions and many informal reading materials do not contain any. Therefore, automatic question generation has great potential in education as it may alleviate the lack of questions. However, currently, there is insufficient evidence on whether or not those automatically generated questions are beneficial for learners' understanding in reading comprehension scenarios.ObjectivesWe investigate the positive and negative effects of automatically generated short-answer questions on learning outcomes in a reading comprehension scenario.MethodsA learner-centric, in between-groups, quasi-experimental reading comprehension case study with 48 college students is conducted. We test two hypotheses concerning positive and negative effects on learning outcomes during the text comprehension of science texts and descriptively explore how the generated questions influenced learners.ResultsThe results show a positive effect of the generated questions on the participants learning outcomes. However, we cannot entirely exclude question-induced adverse side effects on learning of non-questioned information. Interestingly, questions identified as computer-generated by learners nevertheless seemed to benefit their understanding.Take AwayAutomatic question generation positively impacts reading comprehension in the given scenario. In the reported case study, even questions recognized as computer-generated supported reading comprehension.
Comparative Clinical Study of Percutaneous Epididymal Sperm Aspiration and Testicular Biopsy in the Outcome of ICSI-Assisted Fertility Treatment in Patients with Obstructive Azoospermia
Authors: Li Lian , Liao Hongqing , Li Meiqing , Xiao Jianghua , Wu Lei 
Published: June 2022

ObjectiveTo compare and contrast the effects of percutaneous epididymal sperm aspiration (PESA) and testicular sperm aspiration (TESA) on the outcome of intracytoplasmic sperm injection (ICSI)-assisted fertility treatment in patients with obstructive azoospermia.MethodsPatients with obstructive azoospermia with an age distribution of 20–36 years admitted to the male department of the Reproductive Center of the Second Affiliated Hospital of South China University (Hengyang Nanhua Xing Hui Reproductive Health Hospital) from December 2018 to December 2020 were used in this study. One group was set up as the PESA group to perform PESA, and the other group was set up as the TESA group to perform percutaneous testicular biopsy for sperm extraction. Patients who were unsuccessful in PESA continued to undergo TESA, and if sperm were retrieved, they were classified as the TESA group. General information on male patients and their partners was collected and compared in patients from different sperm source groups. Embryo development (normal fertilization rate, high-quality embryo rate, and high-quality blastocyst rate) and pregnancy outcome (clinical pregnancy rate, miscarriage rate, and ectopic pregnancy rate) were compared between the two groups.ResultsFinally, there were 26 patients in the PESA group and 31 patients in the TESA group. There were no significant differences in terms of age, years of infertility, testosterone level, (FSH) follicle-stimulating hormone level, and testicular volume between the male patients in the PESA and TESA groups of two different sperm sources, and no significant differences were found in the general conditions of the female patients in terms of age, number of eggs obtained, number of sinus follicles, basal FSH value, and basal E2 value (p &gt; 0.05). The rate of high-quality blastocysts in the TESA group was significantly higher than that in the PESA group (p &lt; 0.05); the differences in clinical normal fertilization rate, high-quality embryo rate, clinical pregnancy rate, miscarriage rate, and ectopic pregnancy rate between the two groups were not statistically significant (p &gt; 0.05).ConclusionICSI with different sources of sperm in patients with male factor infertility alone, which had no significant effect on embryo development, embryo implantation rate, clinical pregnancy rate, and miscarriage rate, resulting in better clinical outcomes.
A Comprehensive Electric Vehicle Model for Vehicle-to-Grid Strategy Development
Authors: Rücker Fabian , Schoeneberger Ilka , Wilmschen Till , Chahbaz Ahmed , Dechent Philipp , Hildenbrand Felix , Barbers Elias , Kuipers Matthias , Figgener Jan , Sauer Dirk Uwe 
Published: June 2022

A comprehensive electric vehicle model is developed to characterize the behavior of the Smart e.d. (2013) while driving, charging and providing vehicle-to-grid services. To facilitate vehicle-to-grid strategy development, the EV model is completed with the measurement of the on-board charger efficiency and the charging control behavior upon external set-point request via IEC 61851-1. The battery model is an electro-thermal model with a dual polarization equivalent circuit electrical model coupled with a lumped thermal model with active liquid cooling. The aging trend of the EV’s 50 Ah large format pouch cell with NMC chemistry is evaluated via accelerated aging tests in the laboratory. Performance of the model is validated using laboratory pack tests, charging and driving field data. The RMSE of the cell voltage was between 18.49 mV and 67.17 mV per cell for the validation profiles. Cells stored at 100% SOC and 40 °C reached end-of-life (80% of initial capacity) after 431–589 days. The end-of-life for a cell cycled with 80% DOD around an SOC of 50% is reached after 3634 equivalent full cycles which equates to a driving distance of over 420,000 km. The full parameter set of the model is provided to serve as a resource for vehicle-to-grid strategy development.
May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection?
Authors: Kosecka-Strojek Maja , Wolska-Gębarzewska Mariola , Podbielska-Kubera Adrianna , Samet Alfred , Krawczyk Beata , Międzobrodzki Jacek , Michalik Michał 
Published: June 2022

Staphylococcus lugdunensis is an opportunistic pathogen found in the healthy human skin microbiome bacterial community that is able to cause infections of diverse localization, manifestation, and course, including laryngological infections, such as necrotizing sinusitis. Chronic maxillary sinusitis is a disease present in up to one third of European and American populations, and its etiology is not fully described. Within this study, we aimed to characterize 18 S. lugdunensis strains recovered from maxillary sinuses and evaluate them as etiological agents of chronic disease. We performed MLST analysis, the complex analysis of both phenotypic and genetic virulence factors, antibiotic susceptibility profiles, and biofilm formation assay for the detection of biofilm-associated genes. Altogether, S. lugdunensis strains were clustered into eight different STs, and we demonstrated several virulence factors associated with the chronic disease. All tested strains were able to produce biofilm in vitro with numerous strains with a very strong ability, and overall, they were mostly susceptible to antibiotics, although we found resistance to fosfomycin, erythromycin, and clindamycin in several strains. We believe that further in-depth analysis of S. lugdunensis strains from different niches, including the nasal one, should be performed in the future in order to reduce infection rate and broaden the knowledge about this opportunistic pathogen that is gaining attention.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH KAWISTA (LIMONIA ACIDISSIMA) TERHADAP ESCHERICHIA COLI
Authors: Veryanti Putu Rika Rika , Kusuma Ika Maruya 
Published: June 2022

Escherichia coli is a normal bacteria lives in the large intestine to help the process and maintain human digestive health. However, there are certain types of Escherichia coli which are pathogenic to human body and cause infections, such as diarrhea, urinary tract infections, meningitis, sepsis and so on. Irrational use of antibiotics leads to bacterial resistance to antibiotics. Kawista is one of the fruits that used as traditional medicine in Indonesia. Kawista peel extract can be used as an alternative therapy to prevent resistance. Based on the content of secondary metabolites, kawista peel extract is thought to have antibacterial activity. The purpose of this study was to determine the antibacterial activity of kawista (Limonia accidisima) peel extract against Escherichia coli. This research is an in-vitro study, preceded by a phytochemical screening test for methanol extract of kawista peel, then followed by an antibacterial activity test using the disc diffusion method and determining the minimum inhibitory concentration (MIC). The results showed that the kawista peel extract contained secondary metabolites such as alkaloids, flavonoids, saponins, tannins and terpenoids which have antibacterial activity. The concentration of the extract is directly proportional to its antibacterial activity. The 5% extract concentration gave an average inhibition zone diameter of 8.81 mm (moderate antibacterial activity), while at the 80% extract concentration the average inhibition zone diameter was 22.71 mm (very strong bacterial activity). Kawista peel extract (Limonia acidissima) has antibacterial activity with a minimum inhibitory concentration of 5%. Keywords: Antibacterial, Kawista, Limonia acidissima, Escherichia coli
Study of quality of life in patients with seborrheic keratosis using different treatment regimens
Authors: Makurina G. I. , Cherneda L. O. 
Published: June 2022

Objective of this work is to evaluate the effect of a new topical treatment scheme for seborrheic keratosis on the quality of life in comparison with invasive electrocoagulation technique in terms of secondary changes in the skin (dyschromia, scarring).
Materials and methods. 90 patients with seborrheic keratoses (77 females (85.6%), 13 males (14.4%)) were examined at the "University Clinic" and the Department of Dermatovenerology and Cosmetology with the Course of Aesthetic Medicine of FPE of ZSMU. Clinical, dermatoscopic, ultrasound, and pathomorphological examinations were performed for diagnostic purposes. The patients were randomly allocated into 2 groups. Local therapy was recommended as treatment for the first group (n=60). Patients in the second group (n=30) were prescribed electrocoagulation to remove neoplasms. Quality of life was assessed using the standardized DLQI index. The degree of discomfort with the application of a 30% hydrogen peroxide solution was assessed using a visual analog scale.
Results. Only 13 patients (21,66%) in Group I had secondary skin changes in the form of hypopigmentation. At the same time 26 (86,66%) patients of Group II had an undesirable result after removal in the form of scar changes. Assessment of quality of life also indicates a significant difference when comparing topical and invasive treatment. According to the questionnaire results, patients in the main group had a score of 5 (4;6), whereas in the case of electrocoagulation removal the score was 7 (6;9) (U=373.5; p=0,000005).
Conclusions. The use of topical agents in the treatment of seborrheic keratosis demonstrates effective efficacy in the extent of skin clearing of these neoplasms.