bluuebunny/crossref_metadata_2025_split huggingface dataset:
La formación reglada en interpretación del patrimonio avanza en España con la consecución de la cualificación profesional
Authors: Jiménez Luquin Alberto 
Published: June 2022

Tras varios años de trabajo de no pocas personas del Seminario de Interpretación del Patrimonio del Centro Nacional de Educación Ambiental (CENEAM) y de la Asociación para la Interpretación del Patrimonio de España (AIP), se cuenta ya con unas bases de referencia para avanzar en la formación reglada en interpretación del patrimonio en España. Es decir, tenemos un conjunto de estándares de competencias, con significación para el empleo, que podrán ser adquiridas mediante formación y a través de la experiencia laboral.
La formación reglada en interpretación en España se desarrolla de forma puntual a través de cursos de posgrado y másteres en algunas universidades. Con este avance se abren nuevas posibilidades de vías formativas para nuevos y nuevas profesionales en un futuro próximo, así como líneas de acreditación para profesionales actuales.
Desarrollo de la lectura en los estudiantes del tercero de básica: una experiencia con aplicaciones silábico
Authors: Ortega-Ortega José , Apolo-Buenaño Diego , Erazo-Álvarez Juan 
Published: June 2022

En el presente trabajo se llevará a cabo en la escuela de EGB “Leopoldo Cordero Alvarado”, de la provincia del Cañar, cantón Azogues, parroquia Cojitambo, en la comunidad de San Jacinto, con estudiantes de tercer año de educación General Básica, por la necesidad de mejorar la deficiencia de la lectura, aplicando las apps digitales e interactivas “Silábico”, la misma que fomentará a los usuarios un aprendizaje y práctica de la lectura, de una manera dinámica e innovadora. Los docentes podemos aplicar este recurso para reforzar el aprendizaje de la lectura, logra una mayor concentración y mejorar sus destrezas lectoras; por su contenido de fácil manipulación y acceso intuitivo, dando un uso didáctico a los dispositivos tecnológicos como los celulares, tabletas o pc, se puede utilizar estas aplicaciones sin la necesidad de conectarse a una red de internet; el acceso a un dispositivo móvil lo tenemos mínimo uno por cada hogar, por ello se debe explotar al máximo este recurso tecnológico en casa con sus padres.
Evaluation of differnt sowing methods for enhancing productivity and water use efficiency of wheat under limited water condition
Authors: Riaz Atif , Aziz Mudassir , Ghaffar Abdul , Ahmed Wazir , Mubeen Khuram , Usman Muhammad 
Published: June 2022

Drought is a serious threat for food security worldwide. Wheat is most popular staple crop of world severely affected by drought at water sensitive crop growth stages. Selection of appropriate sowing method is very important for improving water use efficiency. A field trial was conducted in winter season of 2018-19 to investigate the impact of different sowing methods on water use efficiency of spring wheat exposed to water deficit at anthesis. Wheat was sown with three different sowing methods viz. broadcast sowing, drill sowing and augmented furrow sowing and two different irrigation regimes i.e. normal irrigation and water deficit at anthesis stage. All agronomic practices were kept uniform throughout the experiment. Different sowing methods and irrigation regimes significantly affected grain and straw yield of wheat. Among different sowing methods, wheat crop sown with augmented furrow method produced maximum plant height (111 cm), no. of tillers per m2 (427), 1000 grain weight (37.93 g), grain yield (4.73 t ha-1) and straw yield (4.24 t ha-1). Maximum irrigation water use efficiency (17.72 kg ha-1 mm-1) and benefit cost ratio (1.34) was recorded in augmented furrow method of sowing of wheat exposed to water deficit at anthesis stage.
Plasma Homocysteine Level Is Independently Associated With Conventional Atherogenic Lipid Profile and Remnant Cholesterol in Adults
Authors: Zhou Liyuan , Liu Jia , An Yu , Wang Ying , Wang Guang 
Published: June 2022

BackgroundHomocysteine (Hcy) is an independent risk factor for cardiovascular disease, while mechanisms are unclear. Despite inconsistent and limited, epidemiological and experimental studies indicated that hyperhomocysteinemia (HHcy) affected lipid metabolism. This study aims to investigate the association of plasma Hcy with traditional lipid profiles and remnant cholesterol (RC) in Chinese adults.MethodsIn total, 7,898 subjects aged 20–79 years who underwent a physical examination at Beijing Chao-Yang Hospital in Beijing were included in this study. Fasting plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), lipoprotein (a) [Lp(a)], Hcy, and other metabolic risk factors were measured by routine automated laboratory methods. RC was calculated as TC minus HDL-C and LDL-C. The linear regression model and logistic regression model were used to assess the relationship between Hcy and lipids after adjusting potential confounders.ResultsOf the subjects, the median level of plasma Hcy was 13.0 μmol/L and 32.3% had HHcy. Plasma Hcy was negatively associated with HDL-C, ApoA1, and Lp(a) and positively associated with TG levels after adjusting age, sex, body mass index, blood pressure, alanine transaminase, aspartate transaminase, creatinine, uric acid, and glucose. HHcy significantly increased the risk of low HDL-C [odds ratio (OR) 1.26; 95%CI (1.11–1.44); p &lt; 0.001]. The net mediation effects of ApoA1 on the relationship between Hcy and HDL-C before and after adjusting confounders were 46.9 and 30.6%, respectively. More interestingly, the RC level was significantly elevated in subjects with HHcy after adjusting other influencing factors (p = 0.025). Hcy presented a positive correlation with RC levels after adjusting the above confounding factors (β = 0.073, p = 0.004), and the correlation was still significant even after controlling other lipids, including TG, LDL-C, HDL-C, ApoA1, ApoB, and Lp(a).ConclusionOur study showed that plasma Hcy was not only significantly associated with conventional atherogenic lipids but also independently correlated with RC levels beyond other lipids after controlling potential confounders. This finding proposes that identifying Hcy-related dyslipidemia risk, both traditional lipids and RC residual risk, is clinically relevant as we usher in a new era of targeting Hcy-lowering therapies to fight against dyslipidemia or even cardiovascular disease.
A 3-Year Single Center Experience With Left Atrial Pressure Remote Monitoring: The Long and Winding Road
Authors: Restivo Attilio , D'Amario Domenico , Paglianiti Donato Antonio , Laborante Renzo , Princi Giuseppe , Cappannoli Luigi , Iaconelli Antonio , Galli Mattia , Aspromonte Nadia , Locorotondo Gabriella , Burzotta Francesco , Trani Carlo , Crea Filippo 
Published: June 2022

BackgroundDespite continuous advancement in the field, heart failure (HF) remains the leading cause of hospitalization among the elderly and the overall first cause of hospital readmission in developed countries. Implantable hemodynamic monitoring is being tested to anticipate the clinical exacerbation onset, potentially preventing an emergent acute decompensation. To date, only pulmonary artery pressure (PAP) sensor received the approval to be implanted in symptomatic heart failure patients with reduced ejection fraction. However, PAP's indirect estimation of left ventricular filling pressure can be inaccurate in some contexts.MethodsThe VECTOR-HF study (NCT03775161) is examining the safety, usability and performance of the V-LAP system, a latest-generation device capable of continuously monitoring left atrial pressure (LAP). In our center, five advanced HF patients have been enrolled. After confirmation of the transmitted data reliability, LAP trends and waveforms have guided therapy optimization. The aim of this work is to share clinical insights from our center preliminary experience with V-LAP application.ResultsOver a median follow-up time of 18 months, LAP–based therapy optimization managed to reduce intracardiac pressure over time and no hospital readmission occurred. This result was paralleled by an improvement in both functional capacity (6MWT distance 352.5 ± 86.2 meters at baseline to 441.2 ± 125.2 meters at last follow-up) and quality of life indicators (KCCQ overall score 63.82 ± 16.36 vs. 81.92 ± 9.63; clinical score 68.47 ± 19.48 vs. 83.70 ± 15.58).ConclusionPreliminary evidence from V-LAP application at our institution support a promising efficacy. However, further study is needed to confirm the technical reliability of the device and to exploit the clinical benefit of left-sided hemodynamic remote monitoring.
Ross Procedure in the era of Handmade-Valved Conduits for Right Ventricular Outflow Tract Reconstruction in Children: Short-Term Surgical Outcomes
Authors: Dong Wei , Chen Dian , Jiang Qi , Hu Renjie , Qiu Lisheng , Zhu Hongbin , Zhang Wen , Zhang Haibo 
Published: June 2022

ObjectiveRoss procedure is considered as the “gold standard” for aortic valve replacement, but the conduits used for right ventricular outflow tract (RVOT) reconstruction, such as homografts and bovine jugular vein (BJV) conduits, are of limited availability in China. Handmade expanded polytetrafluoroethylene-valved conduits (HVCs) have been used recently as the alternative for RVOT reconstruction, but their specific experience in Ross procedure is limited in the literature.MethodsThis was a retrospective review of 27 children who underwent Ross procedure in our center from January 2018 to January 2022.ResultsMean age at surgery was 8.0 ± 3.8 years. During the study period, BJV conduits were used for RVOT reconstruction in 6 patients (22%), and HVCs were used in 21 patients (78%). Median conduit size was 20 mm (range, 16–24 mm), and mean conduit Z-score was +0.8 ± 0.9. Median time for cardiopulmonary bypass was 158 min (range, 109–275 min), and mean time for aortic crossclamping was 110 ± 21 min. There was no early mortality. During a median follow-up time of 1.4 years (range, 0.1–3.7 years), 3 patients (11%) with BJV conduits had peak conduit velocity of &gt; 3.5 m/s; 3 patients (11%) with HVCs developed moderate conduit insufficiency; no patients had more than moderate conduit insufficiency. Three patients with BJV conduits had 5 reinterventions, and all received conduit replacement with HVCs.ConclusionHVC is an appealing alternative to BJV conduit for RVOT construction for children undergoing Ross procedure, with favorable short-term outcomes.
Investigating Potential Links Between Fine-Grained Components in Loess and Westerly Airflow: Evidence From East and Central Asia
Authors: Li Yue , Song Yougui , Fitzsimmons Kathryn E. , Dave Aditi K. , Liu Yuming , Zong Xiulan , Sun Huanyu , Liu Huifang , Orozbaev Rustam 
Published: June 2022

Loess is a ubiquitous, silty aeolian sediment common across the semiarid to subhumid regions in the Northern Hemisphere. As such, the physical characteristics of loess sediment, such as modal grain size and quartz crystallinity index, have the potential to inform us about dust transport pathways and corresponding atmospheric circulation responsible for entrainment, transport, and deposition. In this article, we combine detailed granularity analyses and non-parametric end-member modeling with investigations of the quartz crystallinity index of three loess deposits, extending from East to Central Asia, with the aim of identifying dust transport processes and the climate subsystems responsible for them. We find marked differences in the grain size characteristics of Eastern and Central Asian loess. Given potential linkages of fine particles to the westerly jet stream, here we focused on the fine-grained end-members in the loess. The fine-grained components of the Central Asian Bishkek (BSK) and Chashmanigar (CMG) loess may be derived from individual particles carried at high altitude by major climate subsystems such as the westerlies. However, similar quartz crystallinity indexes of fine- and coarse-grained components in the Central Asian loess indicated that surface-level wind strength might influence the releases from proximal-sourced regions and abundances in the upper atmosphere for the fine particles. By contrast, the fine-grained component of the East Asian [Fanshan18 (FS18)] loess seems to yield physical similarities to the Tertiary Red Clays underlying many loess stratigraphies, and has been interpreted to relate to transport associated with the East Asian winter monsoon. It was further supported by quartz crystallinity indexes of the &lt;16 μm fractions in the FS18 loess, basically consistent with those of the deserts in North China, highlighting the near-surface northwesterly winter monsoon as the dominant transport dynamics of fine-grained dust. In addition, comparisons of quartz crystallinity indexes of fine-grained components between the East and Central Asian loess also suggest that variations in fine particles within the loess might not be related to transport by the higher-level westerlies, which is in disagreement with the previous model. Therefore, our results indicate that variations in fine-grained end-members in loess are difficult to reliably document the variabilities of higher-level westerlies.
Accelerated Shrinkage of Glaciers in the Altai Mountains From 2000 to 2020
Authors: Chang Jiawen , Wang Ninglian , Li Zhijie , Yang Daqing 
Published: June 2022

Mountain glaciers are an important component of the global hydrological cycle. Existing research about glacier changes in the Altai focused on limited regions. Study about recent glacier changes in the entire Altai Mountains is still lacking. We presented a consistent method for identifying glacier margins. The two new glacier inventories in 2000 and 2020 were derived from Landsat satellite imagery. Glacier surface elevation change and mass balance were obtained by comparing the 2000 Shuttle Radar Topography Mission (SRTM) and 2020 Digital Elevation Models (DEMs) generated from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) images. The spatial pattern of glacier changes was discussed in conjunction with climate trends. We mapped a total area of 1,096.06 ± 53.32 km2around 2020, which amounts to 1,927 glaciers in the Altai Mountains. That was 12.02 ± 3.01% (or 0.60 ± 0.15%·a−1) less than the 1,245.75 ± 58.52 km2around 2000. The geodetic mass balance of the monitoring glaciers in the Aktru basin for the period 2000–2011 was used to validate the geodetic survey. The average geodetic mass balance of -0.32 ± 0.09 m w. e.·a−1on monitoring glaciers was slightly exaggerated than the observed mass balance of -0.26 m w. e.·a−1, but it was proved that the geodetic mass balance could reflect glacier changes in the Altai Mountains. An average mass loss of 14.55 ± 1.32 m w. e. (or 0.74 ± 0.07 m w. e.·a−1) was found during 2000–2020 in the Altai Mountains. Although the glacier area changes and mass balance were characterized by spatial heterogeneity, the glaciers in the Altai had experienced an accelerated shrinkage from 2000 to 2020 compared to the 20th century. The rising temperature is the foremost reason for glacier area shrinkage and mass loss according to the Climatic Research Unit (CRU) reanalysis data.
Biomechanical Comparison of Six Different Root-Analog Implants and the Conventional Morse Taper Implant by Finite Element Analysis
Authors: Wang Jia-Qing , Zhang Yuan , Pang Min , Wang Yue-Qiu , Yuan Jun , Peng Hui , Zhang Wen , Dai Lu , Li Hong-Wei 
Published: June 2022

Taper implants differ greatly from anatomical teeth in shape. In this study, seven three-dimensional finite element models were established, including a conventional taper implant and six root-analog implants with different root numbers and shapes. Vertical, horizontal, and oblique instantaneous loads of 100 N were applied to the models to obtain stress distribution in the implant, mucosa, cortical bone, and cancellous bone. ANSYS was used to perform the analysis under hypothetical experimental conditions. We find the stresses in all the implants and surrounding tissues varied by loading direction, the sequence of stress magnitude is vertical load, oblique load, and then horizontal load. The maximum stress values in root-analog implants were significantly less than in the taper implant. Moreover, stress distribution in the former was equalized contrary to the concentrated stress in the latter. Root-analog implants with different root geometry also revealed a pattern: stresses in multiple-root implant models were lower than those in single-root implants under the same load. The implant with a long and rounded root distributed the stress more uniformly, and it was mainly concentrated on the implant itself and cancellous bone. However, the opposite effect was observed in the short implant on mucosa and cortical bone. The root geometry of anatomical teeth can modify their functions. A uniform-shaped implant can hardly meet their functional requirements. Thus, the root-analog implant could be a possible solution.
The Designated Shipping Avoidance Area Around St. Lawrence Island, Northern Bering Sea, Is not Sufficient to Protect Foraging Habitat of the Island’s Breeding Seabird Community
Authors: Thiebot Jean-Baptiste , Will Alexis P. , Tsukamoto Shota , Kitaysky Alexander S. , Takahashi Akinori 
Published: June 2022

One direct consequence of Arctic warming is the expansion of navigable portions of the Arctic Ocean. As a result, vessel traffic and the accompanying threats of spills, strikes and disturbance is intensifying throughout the Arctic. In the Bering Sea, these threats to the environment, wildlife and to the people who rely on marine resources for food and cultural continuity, are acute. We examined the spatial relevance of an Area To Be Avoided (ATBA), a shipping-risk mitigation measure, established around St. Lawrence Island with respect to seabirds, as sentinel species, habitat use. We studied four seabird species (common murre Uria aalge, thick-billed murre U. lomvia, crested auklet Aethia cristatella, black-legged kittiwake Rissa tridactyla) breeding at St. Lawrence Island in the northern Bering Sea. GPS tracking data from 47 at-sea foraging trips showed that both murre species and crested auklets distributed outside the ATBA, during at least one stage of the breeding season. A larger dataset based on the birds’ red blood cell isotopic signatures confirmed that for murres, the tracked individuals covered the broad niche exploited by these species. Habitat modelling further showed that the birds’ most suitable marine habitats were associated with seasonal surface chlorophyll blooms, and largely extended beyond the ATBA on the shelf north of the island. Data on the murres’ diet and diving behavior emphasized the importance of the shelf as a foraging habitat for these birds. We suggest that extending the ATBA to the north by only 35 km, would include areas of maximal habitat suitability. This extension would better protect seabirds, their foraging habitats and the cultural continuity of St. Lawrence Islanders, against growing threats stemming from Arctic warming.
Influence of Ocular Residual Astigmatism on the Correction of Myopic Astigmatism by Toric Implantable Collamer Lens: A Comparative Study With Femtosecond Laser Small Incision Lenticule Extraction
Authors: Sun Ling , Zhang Xiaoyu , Ding Lan , Shen Yang , Qian Yishan , Zhou Xingtao 
Published: June 2022

PurposeTo evaluate the influence of the origin of astigmatism on the correction of myopic astigmatism by toric implantable collamer lens (TICL) and compare it with femtosecond laser small incision lenticule extraction (SMILE).MethodsOcular residual astigmatism (ORA) was determined by vector analysis using manifest refraction and Scheimpflug camera imaging of the anterior cornea. One-to-one matching between the TICL and SMILE groups was performed by preoperative manifest refractive astigmatism (RA) and ORA, tolerating a maximum difference of 0.50 diopter (D) for RA and 0.25 D for ORA. Patients of each group were further divided into groups according to ORA (high &gt; 1.0 D; low ≤ 1.0 D). The baseline and 12-month postoperative data were analyzed. Data are expressed as mean ± standard deviation (SD). A value of p less than 0.05 was considered statistically significant.ResultsFor the TICL group, no significant differences in the postoperative RA, safety index, efficacy index, index of success (IOS), correction index (CI), and angle of error (AOE) were found between high (n = 36) and low ORA (n = 36) groups (Mann–Whitney U test, p &gt; 0.05). For the SMILE group, the postoperative RA (high: −0.67 ± 0.43 D, low: −0.39 ± 0.29 D, Mann–Whitney U test, p = 0.003) and IOS (high: 0.50 ± 0.43, low: 0.25 ± 0.23, Mann–Whitney U test, p = 0.003) were greater in the high ORA group. When comparing TICL and SMILE groups, the mean postoperative RA (TICL: −0.48 ± 0.29 D, SMILE: −0.67 ± 0.43 D, Mann–Whitney U test, p = 0.03) and IOS (TICL: 0.32 ± 0.23, SMILE: 0.50 ± 0.43, Mann–Whitney U test, p = 0.03) were significantly higher in the SMILE group when the ORA was &gt;1.0 D.ConclusionBoth TICL and SMILE are effective in correcting myopic astigmatism. ORA has a lesser effect on TICL than on SMILE.
P53-Related Anticancer Activities of Drimia calcarata Bulb Extracts Against Lung Cancer
Authors: Laka K. , Mbita Z. 
Published: June 2022

Current lung cancer treatment strategies are ineffective, and lung cancer cases continue to soar; thus, novel anticancer drugs and targets are needed, and medicinal plants are promising to offer better alternatives. This study was aimed at analysing two p53 splice variants during the potential anticancer activities of Drimia calcarata (Dc) methanol and water extracts against different human lung cancer cell lines of varying p53 mutation status, and these included mutant H1573 and mutant H1437 and p53-wild type (A549) cells. The anticancer activities of the Dc extracts were assessed by establishing the cytotoxic effect and the apoptosis-inducing capacity of these extracts, using the MTT assay and Annexin V analysis, respectively, with the latter confirmed using fluorescence microscopy. The molecular mechanisms induced by these extracts were further evaluated using cell cycle analysis and RT-PCR. Both extracts demonstrated safety against noncancerous lung MRC-5 fibroblasts and exhibited significant anticancer potency (p &lt; 0.001) against the H1437 (IC50 values: 62.50 μg/ml methanol extract and 125 μg/ml WE), H1573 (IC50 value: 125 μg/ml for both extracts) and A549 (IC50 value: 500 μg/ml ME). The water extract had no effect on the viability of A549 cells. Treated H1437 cells underwent p53-dependent apoptosis and S-phase cell cycle arrest while H1573 treated cells underwent p53-independed apoptosis and G0/G1 cell cycle arrest through upregulation of p21 mRNA expression levels. The expression levels of STAT1, STAT3, STAT5A and STAT5B genes increased significantly (p &lt; 0.001) following the treatment of H1573 cells with ME and WE. Treatment of H1437 cells with ME upregulated the STAT1, STAT3, STAT5A and STAT5B mRNAs. Our results indicate that the proliferative inhibitory effect of D. calcarata extracts on A549 and H1573 cells is correlated with the suppression of Bcl-2, STAT3 and STAT5B while that is not the case in H1437 cells. Thus, our results suggest that the dysregulation of anti-apoptotic molecules Bcl-2, STAT3, STAT5A and STAT5B in H1437 may play a role in cancer cell survival, which may consequently contribute to the development of p53-mutated non-small human lung cancer. Our results indicate that D. calcarata is a promising source of anticancer agents for the treatment of p53-mutant human non-small lung cancer cells than the p53-wild type human non-small lung cancer cells.