bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroless plating silver nanoparticles mixed in oxidized microcrystalline cellulose for microwave absorption applications
Authors: Sun Guangming , Huang Jintian , Hao Shufen , Zhang Qian 
Published: November 2022

Abstract
The silver nanoparticles (AgNPs) were mixed in TEMPO oxidized microcrystalline cellulose (TOMCC) by electroless plating successfully obtained a green lightweight microwave absorber (TOMCC/AgNPs). The process is simple, efficient and low-cost. The physicochemical properties and surface morphology of TOMCC/AgNPs was characterized and analyzed by SEM, EDS, UV-vis, XRD, XPS, BET, Raman spectroscopy and thermal behavior, while the electromagnetic absorption of fabricated TOMCC/AgNPs were analyzed through vector network. The optimal reflection loss value is -51 dB at 4.7 GHz with a corresponding effective absorption bandwidth is 4 GHz, and the thickness of the layer is 2mm. In addition, the reflection loss value of -46 dB at 11.2 GHz with a corresponding effective absorption bandwidth of 3 GHz, and the reflection loss value of -41 dB at 15.6 GHz with a corresponding effective absorption bandwidth of 4 GHz, which the thickness of layer former was 3mm, and latter 2mm. As a green, lightweight and efficient microwave absorber, the prepared TOMCC/AgNPs has a considerable application prospect in the field of microwave absorption such as stealth technology.
Fostering Research Data Management in Collaborative Research Contexts: Lessons learnt from an ‘Embedded’ Evaluation on designing a ‘Data Story’
Authors: Mosconi Gaia , de Carvalho Aparecido Fabiano Pinatti , Syed Hussain Abid , Randall Dave , Karasti Helena , Pipek Volkmar 
Published: November 2022

Abstract
Research Data Management (RDM) practices – spanning the curation, storage, sharing, and reusability of research data – are foundational to the Open Science (OS) agenda. Because of that, many and various funding institutions are increasingly demanding active engagement of researchers in them. Nevertheless, recent studies suggest that RDM practices are not yet properly integrated into daily research workflows, nor supported by any tools researchers typically use. In this paper, we introduce evaluation results of a technological aid for implementing a design concept called ‘Data Story’, drawing on ideas from digital and data storytelling. This concept has been devised to facilitate the appropriation of RDM practices by researchers working mainly with qualitative data in their daily workflows. It integrates traditional data curation approaches with a more narrative, contextual, and collaborative organizational layer that can be thought of as a ‘story’. Our findings come from a long-term ‘embedded’ evaluation of the concept and show: (1) the potential benefits of engaging with a Data Story for RDM; (2) Data Curation issues and learning opportunities; and (3) a broader set of issues and concerns that remain unaddressed in the current state of play. Our contribution, based on lessons learnt, is to provide a new design approach for RDM and for new collaborative research data practices, one grounded in narrative structures, capable to negotiate between top-down policies and bottom-up practices, which supports ‘reflective’ learning opportunities - with and about data - of many kinds.
Observation of the bone destruction of Qingre Huoxue Decoction in the treatment of active rheumatoid arthritis based on MRI evaluation: study protocol for a multicenter, randomized, double-blinded, controlled clinical trial
Authors: Liu Wei-xiang , 李 达 , Tang 唐晓颇 , Gong Xun , Li Yan-ting , Zhang Yi , Chang Tian , Yue Ming , Wang Jian , Xia Cong-min , Peng Qiu-wei , Song Meng-ge , Zhang Fu-yuan , Guan Jin-zhi , Zhao Yue , Liu Xu , Wang Yong , Yue Yue , Yao Jia-shu , Li Wei-qing , Xie Jing-jing , Jiang Yu-bao , Liu Xiao-ya , Zong Rui-kai , Fan Bing , Wang Xi , Wu Chan-yuan , Zhu Qi , Qin Ying-ying , Guo Yun-Ke , Huang Qing-chun , Jiang Quan 
Published: November 2022

Abstract
Background: Bone destruction is the key and difficult point in the treatment of RA. Studies have found that the use of traditional Chinese medicine Qingre Huoxue Decoction (QRHXD) can effectively reduce disease activity and delay bone destruction. Magnetic resonance imaging (MRI) is one of the effective ways to evaluate bone destruction in RA in real time, which is helpful to the early evaluation and discovery of synovitis and bone destruction. Therefore, we designed a multicenter, randomized, double-blinded, controlled clinical trial to assess the improvement of the bone destruction of QRHXD in treating RA using MRI.
Methods: This study aimed to assess the definitive evidence that the traditional Chinese medicine QRHXD slows bone destruction in RA using MRI. A total of 204 adult participants with RA will be enrolled, with balanced treatment allocation (1:1). The experimental intervention will be QRHXD plus MTX and the control intervention will be QRHXD placebo plus MTX for 24 weeks. The primary outcome measure will be RA MRI score at screening period and 24 weeks. Secondary outcome measures will include the ACR20, ACR50 and ACR70, DAS28, patient report outcome(PRO), health assessment questionnaire(HAQ) and X-ray sharp score of both hands. In addition, the vital signs and adverse reactions of the subjects will be recorded.
Discussion: The purpose of this study is to use MRI to confirm that QRHXD can effectively slow the imaging progress of active RA. To provide evidence for the efficacy of Chinese medicine in delaying bone destruction in RA, and help to carry out more clinical research on Chinese medicine prescriptions.
Trial registration number Clinical Trials.gov ID: NCT04170504.
Provider implicit and explicit bias in person-centered maternity care: a cross-sectional study with maternity providers in Northern Ghana
Authors: Afulani Patience A , Okiring Jaffer , Aborigo Raymond A. , Nutor Jerry John , Kuwolamo Irene , Dorzie John Baptist K , Semko Sierra , Okonofua Jason A. , Mendes Wendy Berry 
Published: November 2022

Abstract
Background
Person-centered maternity care (PCMC) has become a priority in the global health discourse on the quality of care due to the high prevalence of disrespectful and lack of responsive care during facility-based childbirth. Although PCMC is generally sub-optimal, there are significant disparities. On average, women of low socioeconomic status (SES) tend to receive poorer PCMC than women of higher SES. Yet few studies have explored factors underlying these inequities. In this study, we examined provider implicit and explicit biases that could lead to inequities PCMC based on SES.
Methods
Data are from a cross-sectional survey with 150 providers recruited from 19 health facilities in the Upper East region of Ghana from October 2020 to January 2021. Explicit SES bias was assessed using situationally-specific vignettes (low SES and high SES characteristics) on providers’ perceptions of women’s expectations, attitudes, and behaviors. Implicit SES bias was assessed using an Implicit Association Test (IAT) that measures associations between women’s SES characteristics and providers’ perceptions of women as ‘difficult’ or ‘good’. Analysis included descriptive statistics, mixed-model ANOVA, and bivariate and multivariate linear regression.
Results
The average explicit bias score was 18.1 out of 28 (SD = 3.60) for the low SES woman vignette and 16.9 out of 28 (SD = 3.15) for the high SES woman vignette (p < 0.001), suggesting stronger explicit bias towards the lower SES woman. These biases manifested in higher agreement to statements such as the low SES woman in the vignette is not likely to expect providers to introduce themselves and is not likely to understand explanations. The average IAT score was 0.80 (SD = 0.34), indicating a significant bias in associating positive characteristics with high SES women and negative characteristics with low SES women. Providers with higher education and years of experience had significantly lower explicit bias scores than those with lower education and experience. Providers in private facilities had higher IAT scores than those in government hospitals.
Conclusions
The findings provide evidence of both implicit and explicit SES bias among maternity providers. These biases need to be addressed in interventions to achieve equity in PCMC and to improve PCMC for all women.
Neutrophil Lymphocyte Ratio (NLR) and Systemic Immune Inflammatory Index (SII) for the Differential Diagnosis of CT-Negative Mild Acute Ischemic Stroke and Transient Ischemic Attack
Authors: Agard Tyler , Hass Rotem , Cavrak Megan , Foual Nour , Byrum Casey , Adcock Amelia , Gehan Donald , Petrone Ashley 
Published: November 2022

Abstract
Background: A number of acute ischemic stroke (AIS) cases may be misdiagnosed as transient ischemic attack (TIA), due to no infarct on initial computed tomography scan and/or mild deficits upon presentation. Several studies have found that neutrophil-lymphocyte ratio (NLR) is an accurate differential diagnostic biomarker for AIS versus TIA; however, no study has evaluated the use of the NLR in differentiating CT negative AIS from TIA. Further, the systemic immune-inflammation index (SII) is a relatively novel immune biomarker that has been shown to be positively correlated with AIS severity, poor functional outcomes and mortality. The purpose of this study is to determine if NLR or SII can be used as a diagnostic biomarker for the differential diagnosis of mild AIS with negative CT upon admission and TIA.
Methods: We performed a retrospective medical record review of patients diagnosed with either AIS or TIA. We collected peripheral white blood cell counts within 24 hours of symptom onset and calculated the NLR and SII. Logistic regression was utilized to determine if NLR or SII are significant predictors of CT negative mild AIS.
Results: CT negative mild AIS patients were 2 times as likely to have an NLR ³ 2.71 compared to TIA patients, and CT negative mild AIS patients were 2.1 times as likely to have an SII ³595 compared to TIA patients.
Conclusion: NLR and SII are easily obtained biomarkers that can be used in early clinical decision making in cases of mild AIS with negative CT scan upon admission.
Clinical and experimental evidence suggest omicron SARS-CoV-2 is inherently less pathogenic than delta independent of previous immunity
Authors: Thiruvengadam Ramachandran , Rizvi Zaigham Abbas , Raghavan Sreevatsan , Murugesan Deepika Rathna , Gosain Mudita , Dandotiya Jyotsna , Ayushi Ayushi , Samal Sweety , Pandey Anil K , Wadhwa Nitya , Bhatnagar Shinjini , Awasthi Amit , Garg Pramod Kumar 
Published: November 2022

Abstract
Objective -To study clinical disease outcomes in both humans and animal models to understand the pathogenicity of omicron compared to delta variant.
Methods- In this cross-sectional observational study, clinical outcomes of adults who tested positive at 2 testing centres in Delhi National Capital Region between January 2022 and March 2022 (Omicron infected; N=2998) were compared to a similar geographical cohort (Delta infected; N=3292). Additionally, disease course and outcomes were studied in SARS-CoV2 infected golden Syrian hamster and K-18 humanized ACE2 transgenic mice.
Results- Omicron variant infection was associated with milder clinical course [83% (95% CI: 61, 94) reduced risk of severity compared against delta] adjusting for vaccination, age, sex, prior infection and occupational risk. This correlated with lower disease index and viral load scores when comparing omicron with other variants in animal models.
Conclusion- Infections caused by the omicron variant is milder compared to delta independent of previous immunity.
The ribosomal protein P0A is required for embryo development in rice
Authors: Chang Zhenyi , Wang Xia , Pan Xiaoying , Yan Wei , Wu Wenshi , zhuang Yi , Li Zhiai , Wang Dan , Yuan Shuting , Xu Chunjue , Chen Zhufeng , Liu Dongfeng , Chen Zi Sheng , Tang Xiaoyan , Wu Jianxin 
Published: November 2022

Abstract
The P-stalk is a conserved and vital structural element of ribosome. The eukaryotic P-stalk exists as a P0-(P1-P2)2 pentameric complex, in which P0 function as a base structure for incorporating the stalk onto 60S pre-ribosome. There is only a single copy of P0 gene in yeast and most animal species. Prior studies have suggested that P0 genes are indispensable for survival in yeast and animals. In contrast, each plant species has at least two copies of P0 genes, however, the functions of P0 genes in plants remain elusive. In the present study, we show that rice has three P0 genes predicted to encode highly conserved proteins OsP0A, OsP0B and OsP0C. All of these P0 proteins were localized both in cytoplasm and nucleus, and conversely interacted with OsP1. Intriguingly, the transcripts of OsP0A presented more than 90% of the total P0 transcripts. Moreover, knockout of OsP0A led to embryo lethality, while single or double knockout of OsP0B and OsP0C did not show any comparable phenotypes in rice. The genomic DNA of OsP0A could well complement the phenotypes of osp0a mutant. Finally, sequences and syntenic analyses revealed that OsP0C evolved from OsP0A, and that duplication of genomic fragment harboring OsP0C further gave birth of OsP0B, and both of these duplication events happened prior to the differentiation of Xian and Geng subspecies in rice ancestor. Together, our data indicate that OsP0A functions as the predominant P0 gene, playing an essential role in embryo development in rice.
Large Scale Genealogical Information Extraction From Handwritten Quebec Parish Records
Authors: Tarride Solène , Maarand Martin , Boillet Mélodie , McGrath James , Capel Eugénie , Vézina Hélène , Kermorvant Christopher 
Published: November 2022

Abstract
This paper presents a complete workflow designed for extracting information from Quebec handwritten parish registers. The acts in these documents contain individual and family information highly valuable for genetic, demographic and social studies of the Quebec population. From an image of parish records, our workflow is able to identify the acts and extract personal information. The workflow is divided into successive steps: page classification, text line detection, handwritten text recognition, named entity recognition and act detection and classification. For all these steps, different machine learning models are compared. Once the information is extracted, validation rules designed by experts are then applied to standardize the extracted information and ensure its consistency with the type of act (birth, marriage, and death). This validation step is able to reject records that are considered invalid or merged. The full workflow has been used to process over two million pages of Quebec parish registers from the 19-20th centuries. On a sample comprising 65% of registers, 3.2 million acts were recognized. Verification of the birth and death acts from this sample shows that 74% of them are considered complete and valid. These records will be integrated into the BALSAC database and linked together to recreate family and genealogical relations at large scale.
Intact mass analysis reveals the novel O-linked glycosylation on the stalk region of PD-1 protein
Authors: Tit-oon Phanthakarn , Wonglangka Arisa , Boonkanta Klaichan , Ruchirawat Mathuros , Fuangthong Mayuree , Khongmanee Amnart , Sasisekharan Ram 
Published: November 2022

Abstract
Programmed cell death protein 1 (PD-1) is a key receptor in the immune checkpoint pathway and has emerged to be a promising target for cancer therapy. PD-1 consists of an intracellular domain followed by a transmembrane domain that is connected to the extracellular domain by the stalk region. Although the PD-1 structure has been studied for more than two decades, the posttranslational modification of this protein has been incompletely characterized. In this study, we identified the previously undescribed modification sites of O-linked glycan on the stalk region of PD-1 protein using O-protease digestion coupling with intact mass analysis. The result indicates that T153, S157, S159, and T168 are modified by sialylated mucin-type O-glycan with core 1–and core 2–based structures. This study provides both information on potential novel modification sites on the PD-1 protein and an attractive method for identifying O-linked glycosylation using a specific enzyme and intact mass analysis.
On-Chip Liquid and Gas Flow Rate Sensing via Membrane Deformation and Bistability Probed by Microwave Resonators
Authors: Secme Arda , Pisheh Hadi Sedaghat , Uslu H. Dilara , Tefek Uzay , Kucukoglu Berk , Alatas Ceren , Kelleci Mehmet , Hanay M. Selim 
Published: November 2022

Abstract
Precise monitoring of fluid flow rates constitutes an integral problem in various lab-on-a-chip applications. While off-chip flow sensors are commonly used, new sensing mechanisms are being investigated to address the needs of increasingly complex lab-on-a-chip platforms which require local and non-intrusive flow rate sensing. In this regard, the deformability of microfluidic components has recently attracted attention as an on-chip sensing mechanism. To develop an on-chip flow rate sensor, here we utilized the mechanical deformations of a 220 nm thick Silicon Nitride membrane integrated with the microfluidic channel. Fluid flow induces deformations on the membrane, which is electronically probed by the changes in the capacitance and resonance frequency of an overlapping microwave resonator. By tracking the resonance frequency, both liquid and gas flows were probed with the same device architecture. For liquid flow experiments, a secondary sensing mechanism emerged when it was observed that steady liquid flow induces periodic deformations on the membrane. Here, the period of membrane deformation depends on the flow rate and can again be measured electronically by the microwave sensor. Flow rate measurements based on the deformation and instability of thin membranes demonstrate the transduction potential of microwave resonators for fluid-structure interactions at micro and nanoscales.
Association of the triglyceride-glucose index with risk of Alzheimer’s disease: a prospective cohort study
Authors: Sun Junyi , Xie Zengshuo , Wu Yuzhong , Liu Xiao , Ma Jianyong , Dong Yugang , Liu Chen , Ye Min , Zhu Wengen 
Published: November 2022

Abstract
Background
Triglyceride-glucose (TyG) index is a reliable surrogate marker of insulin resistance (IR), whereas IR has been implicated in Alzheimer’s disease (AD) pathophysiology. However, the relationship between the TyG index and AD remains unclear. Herein, we aimed to evaluate the associations of both baseline level and long-term trajectories of the TyG index with the risk of AD.
Methods
This prospective study included 2,170 participants free of AD from the Framingham Heart Study Offspring cohort. The TyG index was calculated as Ln[fasting triglyceride (mg/dL)×fasting glucose (mg/dL)/2]. Data for the TyG index from three examinations were used to identify the long-term trajectories of the TyG index by latent class growth mixture modeling analysis. The Cox and logistic regression models were applied to evaluate the associations of the baseline level and long-term trajectories of the TyG index with AD.
Results
During a median follow-up of 13.8 years, 163 (7.5%) participants developed AD. Each unit increment of baseline TyG index was associated with a 39% increased risk of AD (adjusted hazard ratio [HR] 1.39, 95% confidence interval [CI] 1.02–1.88). When compared with the reference (TyG index ≤ 8.28), we observed a significantly elevated risk of AD in the group with TyG index of 8.68–9.09 (adjusted HR 1.69, 95% CI 1.03–2.77). In addition, three long-term trajectories of the TyG index were identified (low-stable [95.3%], intermediate-remitting [2.1%], and high-decreasing [2.6%] trajectory group). There was no significant difference in AD risk among the three groups.
Conclusions
Our findings first showed that a higher baseline TyG index was associated with an increased incidence of AD. The TyG index might be used as a simple surrogate marker for the early detection of AD.
Parental pressure on child body image, body mass index, body image dissatisfaction associated with eating disorders among children and adolescents with different developmental stages: A path analysis
Authors: Chen Jiaoyan , Liu Keke , Zhang Juan , Liu Songhui , Wang Yuanyuan , Cao Ruiyao , Peng Xingwang , Han Mei , Han Hui , Yao Rongying , Fu Lianguo 
Published: November 2022

Abstract
Background: The purpose of this study was to analyze the association pathways between parental pressure on children’s body image (PPCBI), body mass index (BMI), body image dissatisfaction (BID) and eating disorders (ED) among children and adolescents with different developmental stages.
Methods: The stratified cluster sampling method was used to select students aged 8–15 years in two 9-year schools. Children's body height, weight, testicular volume and breast development were measured. PPCBI, BID, and ED were investigated using the Appearance-related Social Stress Questionnaire, Body Size Questionnaire (BID-14), and EDI-1 scale, respectively.
Results: The boys with testicular volume <4 ml had significantly higher ED scores than girls with breast development <Tanner II (P<0.05). There were significant association pathways of PPCBI→BMI→BID→ED and PPCBI→BID→ED in boys with testicular volume <4 ml, boys with testicular volume ≥4 ml, and girls with breast development ≥Tanner II. There was a positive association pathway of PPCBI→ED in boys with testicular volume <4 ml and PPCBI→BID→ED in girls with breast development <Tanner II.
Conclusions: Parental pressure on children's body image may positively predict children's eating disorders through BMI and body image dissatisfaction in boys and girls after puberty initiation and directly predict eating disorders in boys before puberty initiation; however, it indirectly predicts eating disorders only through BID in girls before puberty initiation.
Effects of Emission Trading Scheme (ETS) on change rate of carbon emission
Authors: Jung Hail , Song Chang-Keun 
Published: November 2022

Abstract
This paper investigates the effects of Emission Trading Scheme (ETS) adoption on the country-level reduction rate of carbon emission. We first used Environmental Kuznets Curve (EKC) tests to group countries into three categories: inverse U-shaped and gamma-shaped EKC for decoupled countries, and a positive linear EKC for non-decoupled countries. We then examined the effectiveness of ETS adoption. We found ETS was effective for both post-industrial and pre-industrial economies. Compared to countries that have not adopted ETS, the carbon emission reduction (increment) rate of decoupled (non-decoupled) countries that have adopted ETS is faster (slower). Furthermore, ETS adoption significantly reduces overall carbon emissions per capita compared to other global events, such as oil crises. The results imply that a market-based mechanism is an effective strategy for achieving sustainable development, thus, providing insights for policymakers and governments to design effective carbon neutrality policies to achieve sustainable development.