bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circ_001422 aggravates osteosarcoma progression through targeting miR-497-5p/E2F3 axis
Authors: Li Xinyu , Zhao Xin , Li Jin , Zhang Xiaozhan 
Published: June 2022

Abstract
Circ_001422 has been confirmed to be involved in regulating osteosarcoma progression, but its specific mechanism has not been clearly studied. This work aimed to analyze circ_001422’s role in osteosarcoma (OS) cell biological behaviors and the possible molecular mechanisms. This work carried out RT-qPCR for detecting circ_001422, E2F3 and miR-497-5p levels, whereas CCK-8 together with Transwell assays for measuring cell growth, migration as well as invasion abilities. Relation of miR-497-5p with E2F3, as well as circ_001422 with miR-497-5p was analyzed through dual-luciferase reporter gene assay. Protein level was identified by westernblot. According to our results, circ_001422 expression within osteosarcoma tissue significantly increased compared with corresponding healthy samples. Inhibition of circ_001422 significantly decreased OS cell growth, invasion and migration. From mechanism research, miR-497-5p was proved as circ_001422’s target, and E2F3 was miR-497-5p’s target. Besides, miR-497-5p down-regulation or E2F3 overexpression abolished circ_001422 inhibition-mediated inhibition on OS cell proliferation, invasion and migration. Collectively, this study has first suggested circ_001422’s role in enhancing OS proliferation, migration as well as invasion via miR-497-5p/E2F3 axis. Our results will offer new ideas and new anti-OS targets.
Disrupted tenogenesis in masseter as a potential cause of micrognathia
Authors: LIU CHAO , Zhou Nan , Li Nan , Xu Tian , Chen Xiaoyan , Zhou Hailing , Xie Ailun , Liu Han , Zhu Lei , Wang Songlin , Xiao Jing 
Published: June 2022

Abstract
Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple factors involved in the osteogenesis of mandibular bone have contributed to micrognathia, but concerned little on factors other than osteogenesis. In the current study, we found that ectopic activation of Fgf8 by Osr2-cre in the presumptive mesenchyme for the masseter tendon in mice led to micrognathia, masseter regression, and the disrupted patterning and differentiation of masseter tendon. Since Myf5-cre;Rosa26R-Fgf8 mice exhibited the normal masseter and mandibular bone, the possibility that the micrognathia and masseter regression resulted directly from the over-expressed Fgf8 was excluded. Further investigation disclosed that a series of chondrogenic markers were ectopically activated in the developing Osr2-cre;Rosa26R-Fgf8 masseter tendon, while the mechanical sensing in the masseter and mandibular bone was obviously reduced. Thus, it suggested that the micrognathia in Osr2-cre;Rosa26R-Fgf8 mice resulted secondarily from the reduced mechanical force transmitted to mandibular bone. Consistently, when tenogenic or myogenic components were deleted from the developing mandibles, both the micrognathia and masseter degeneration took place with the decreased mechanical sensing in mandibular bone, which verified that the loss of mechanical force transmitted by masseter tendon could result in micrognathia. Furthermore, it appeared that the micrognathia resulting from the disrupted tenogenesis was attributed to the impaired osteogenic specification, instead of the differentiation in the periosteal progenitors. Our findings disclose a novel mechanism for mandibular morphogenesis, and shed light on the prevention and treatment for micrognathia.
Does Social Rigidity predict Cognitive Rigidity? Profiles of Socio-Cognitive Polarization
Authors: Salvi Carola , Iannello Paola , Cancer Alice , Cooper Samuel E. , McClay Mason , Antonietti Alessandro , Dunsmoor Joseph E. 
Published: June 2022

Abstract
Recent research has investigated the relationship between rigid political ideologies and underlying cognitive functions, highlighting discrepancies on how different ‘cognitive styles’ are defined and measured in relation with different shapes of social rigidity. Cognitive rigidity is often operationalized using problem solving which translates into the ability to generate novel and original ideas by exploring unusual reasoning paths and challenging rigid perspectives around us. Thus, we hypothesized a relation between forms of social rigidity, including (socio-cognitive polarization, a factor capturing conservative political ideology, absolutism/intolerance of ambiguity, and xenophobia), believing in bullshit (i.e., overestimating pseudo-profound statements), overclaiming (tendency to self-enhance) and cognitive rigidity (problem solving). Our results showed four latent profiles of social rigidity performance on problem solving tasks. Specifically, those low in socio-cognitive polarization, bullshit, and overclaiming (i.e., less rigid) performed the best on problem solving. Thus, we conclude that social and cognitive rigidity may share an underlying socio-cognitive construct, wherein those who are more socially rigid are also more likely to be also cognitively rigid when processing non-political information.
Independent Assessment of Global Temperature Rise Based Upon Approved Algorithms
Authors: GERSCHULTZ James 
Published: June 2022

Abstract
This is not for a pre-submission inquiry but is provided at your request. This Article describes the total derivation process used for the determination of estimated global temperature increases based upon three prescribed emission reduction pathways. Those pathways were selected to meet the 1.5 C to 2.0 C goals of the Paris Climate Agreement. The derivation includes the methods published in two papers on the estimation of carbon sink values, and the calculation of radiative forcing based upon the atmospheric concentrations of CO2, CH4 and N2O. A new climate sensitivity factor is also derived based upon anomalies in the past temperature profile. Lastly, the reasons for the large differences between this Article and the various Reports from the IPCC, UNEP and CAT are fully explained.
This new assessment shows that the 1.5 C goal can be met by pursuing a linear reduction pathway of 0.6 GtCO2 per year from 40 Gt in 2020 to 12.4 Gt in 2066. Similarly, a 1.7 C goal can be met in 2094 by following a reduction pathway of 0.4 Gt per year to 10.0 Gt at net zero.
Prognostic value of lymph node density on Cancer Staging System for non-metastatic gastric cancer: a population-based analysis of SEER database
Authors: Liu Yuhua , Cui Hao , Xu Xinxin , Liang Wenquan 
Published: June 2022

Abstract
Background
Accurate tumor staging is the cornerstone of tumor treatment. Current tumor staging system for gastric cancer (GC) is based on regional positive lymph nodes while ignoring the total number of examined lymph nodes. We aim to assess the prognostic value of lymph node density (LND), the ratio of positive nodes to the total number examined nodes, in non-metastatic GC.
Methods
Clinical information of patients with histologically confirmed GC and without distal metastasis was identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The X-Tile software was used to identify the ideal prognosis-related cutoff point for LND. The prognostic value of LND on cancer-specific survival (CSS) and overall survival (OS) was assessed in Cox regression models. Subgroup analysis stratified by LND was performed on current lymph node staging system to further explore the interaction between LND and current lymph node staging system.
Results
A total of 4281 participants were identified from the SEER database for the final analysis. The optimal prognosis-related cutoff values of LND were calculated as 0.1 and 0.4, and LND was divided into three levels. The higher level of LND was associated with worse CSS and OS in GC patients. Compared to patients with the lower level of LND, those with the middle and higher level of LND had 2.43 (HR = 2.43, 95% CI 2.09–2.84, P < 0.001) and 4.69 (HR = 4.69, 95% CI 4.02–5.48, P < 0.001) folds increase in mortality in CSS, respectively. Similar results were found in the evaluation of OS in GC patients. Subgroup analysis stratified by LND also found that patients in the same current lymph node stage still had different prognosis due to the different LND levels after adjustment for other prognosis-related covariates (all P values < 0.001).
Conclusion
LND is an independent prognostic factor for non-metastatic GC. In the current lymph node staging system, LND has potential value in further accurately classifying non-metastatic GC patients.
Radiomic features derived from [18F]FET or [18F]GE-180 PET images of gliomas – does feature harmonization facilitate data pooling?
Authors: Zounek Adrian Jun , Albert Nathalie Lisa , Holzgreve Adrien , Unterrainer Marcus , Brosch-Lenz Julia , Lindner Simon , Bollenbacher Andreas , Boening Guido , Rupprecht Rainer , Brendel Matthias , von Baumgarten Louisa , Tonn Joerg-Christian , Bartenstein Peter , Ziegler Sibylle , Kaiser Lena 
Published: June 2022

Abstract
Purpose

Large datasets are required to ensure reliable non-invasive glioma assessment with radiomics-based machine learning methods. This can often only be achieved by pooling images from different centers. Moreover, trained models should perform with high accuracy when applied to data from different centers. In this study, the impact of reconstruction settings and segmentation methods on radiomic features derived from amino acid and TSPO PET images of glioma patients was examined. Additionally, the ability to model and thus reduce feature differences was investigated.

Methods

[ 18 F]FET and [ 18 F]GE-180 PET data were acquired from 19 glioma patients. For each acquisition, 10 reconstruction settings and 9 segmentation methods were included to emulate multicentric data. Statistical robustness measures were calculated before and after ComBat harmonization. Differences between features due to setting variations were assessed using Friedman test, coefficient of variation (CV) and inter-rater reliability measures, including intraclass and Spearman’s rank correlation coefficients and Fleiss’ Kappa.

Results

According to Friedman analyses, most features (> 60%) showed significant differences. Yet, CV and inter-rater reliability measures indicated higher robustness. ComBat resulted in almost complete harmonization (> 87%) according to Friedman test and little to no improvement according to CV and inter-rater reliability measures. [ 18 F]GE-180 features displayed higher sensitivity to reconstruction settings than [ 18 F]FET features.

Conclusions

According to Friedman test, feature distributions could be successfully aligned using ComBat. However, depending on settings, changes in patient ranks were observed for some features and could not be eliminated by harmonization. Thus, for clinical utilization it is recommended to exclude affected features.
A Multi-Rail Structure in the Cell Envelope for the Bacteroidetes Gliding Machinery
Authors: Shibata Satoshi , Tahara Yuhei O. , Katayama Eisaku , Kawamoto Akihiro , Kato Takayuki , Zhu Yongtao , Nakane Daisuke , Namba Keiichi , Miyata Makoto , McBride Mark J. , Nakayama Koji 
Published: June 2022

Abstract
Many bacteria belonging to the phylum Bacteroidetes move on solid surfaces, which is called gliding motility. In our previous study with the Bacteroidetes gliding bacterium Flavobacterium johnsoniae, we proposed a helical loop track model, where adhesive SprB filaments are propelled along a left-handed closed helical loop on the cell surface. Attachment of SprB to the substratum results in cell movement. In this study, we observed the gliding cell rotating counterclockwise about its axis when viewed from the rear to the advancing direction of the cell, which was consistent with the helical loop track model. Total internal reflection fluorescence microscopy of SprB on a gliding cell revealed that one labeled SprB focus sometimes overtook and passed another SprB focus that was moving in the same direction, suggesting the presence of multiple lanes in the helical loop track. Several electron microscopic analyses revealed the presence of a multi-rail structure underneath the outer membrane, which was associated with SprB filaments and contained GldJ protein. A similar structure was observed in the distantly related marine gliding Bacteroidetes Saprospira grandis. These results provide new insights into the mechanism of Bacteroidetes gliding motility, in which the SprB filaments are propelled along the multi-rails underneath the outer membrane.
Analysis of the Change of Productive Matrix of Fossil Fuels by Biofuel in Ecuador
Authors: Nevárez Eddie Zambrano , Murillo Sandra Peña , Correa William 
Published: June 2022

Abstract
The search for energy for humanity’s various activities led to the discovery of fossil fuels such as coal, oil, and natural gas. Today, fossil fuels provide 85% of the energy used worldwide. The use of fossil fuels causes environmental damage that has become more noticeable in recent decades. For this purpose, information is compiled through a bibliographic review of reliable sources such as Springer, Scielo, and other documentary sources, highlighting the advantages and disadvantages of a change in the productive matrix from fossil fuels to biofuels in Latin America. It is concluded that a significant investment must be made to make a difference in the abundant matrix; however, there is a great variety of raw materials in the Latin American area to obtain biofuels, and the necessary technology to process them is not available.
xLightGCN: A Simplified GCN-based Model for Multimedia Recommender System
Authors: JingLi  , Siegal Eithan , Wang Wenting , Libson Zichria , Maibach G. 
Published: June 2022

Abstract
With the gradual development of Internet technology, information resources are growing at a high speed and the problem of information overload has emerged. It is difficult for users to get the information they need directly and quickly from the massive amount of information. Therefore, recommendation algorithms are usually used to solve the problem of information overload, and the research of various recommendation methods. Depending on the implementation idea, recommendation algorithms are mainly classified into three categories: content-based recommendation, collaborative filtering-based recommendation, and hybrid recommendation methods. Collaborative filtering is the most widely used recommendation algorithm, and its main idea is to discover the correlation between users based on their preferences for products, and to make recommendations based on the correlation. Although these methods improve the performance of the recommendation system, when the number of users and products increases, the recommendation system may face the problems of sparsity and cold start, and thus cannot achieve personalized recommendation. The purpose of this paper is to leverage the multi-modal information to address the problem. Specifically, we devise a novel simplified GCN-based model which incorporates the content information extracted from the visual, acoustic, and textual modalities with CF signal by propagating along the item-user bipartite graph. Finally, conducting extensive experiments on public datasets, we demonstrate that our proposed model outperforms several state-of-the-art baselines.
Abulia major and Hypoactive Delirium in COVID-19 reversed with Methylprednisolone Pulse Therapy
Authors: Zanella Luiz Gonzaga Francisco de Assis Barros D’Elia , Zanella Luiz Gonzaga Francisco de Assis Barros D’Elia 
Published: June 2022

Abstract
Background: Sars-CoV-2 is a member of the genus Betacoronavirus like the two other coronaviruses viz. SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus). The SARS-CoV-2 infection has been associated with neuropsychiatric manifestations in acute and chronic COVID-19 (The Long COVID-19 Syndrome), bringing social consequences, and worsening people's quality of life. Overview: This article exemplifies two cases of neurological manifestations resulting from infection by Sars-CoV-2, reversed with Methylprednisolone in pulse - therapy regimen. The first case presents a young patient with symptoms like those existing in patients with Alzheimer's Disease, whose final and presumable diagnosis was Abulia major. The second case exemplifies an elderly person admitted to the hospital due to hypoactive delirium triggered by a urinary tract infection hypothesis. The final diagnosis was Hypoactive Delirium secondary to COVID-19, with urinary manifestations from the SARS-CoV-2 kidney injury. Aim and Conclusion: The purpose of this article is to warn about phenomena related to COVID-19, whose treatment can be performed with high doses of corticosteroids and with drugs that act positively on dopaminergic and serotonergic pathways. Patient exams and more information are available in the Appendix of this article.
Competencias de Tecnología e Innovación en la Enseñanza Híbrida
Authors: Medina Uribe Jury Carla , Huamani Chirinos Hubert Luque , Huamani Chirinos Bruger Gaston , Delgado Carbajal Lilian Amparo 
Published: June 2022

En el presente artículo se realizó una revisión bibliográfica que tuvo por objetivo investigar las competencias de tecnología e innovación en la enseñanza de la educación hibrida, siendo esta la integración de procesos virtuales que reemplazaran algunos de los procesos de la tradicional educación presencial, de tal manera que tanto la educación tradicional como la virtual estén integrados de forma conjunta. Para esto se realizó una revisión del estado del arte sobre las competencias de tecnologías e información indagando en la importancia de las mismas e identificándolas y a su vez expandiendo el contenido del tema de enseñanza híbrida a fin de poder dar referencias para futuros proyectos, concluyendo en la importancia de estas competencias de tecnologías e informaciónpara la enseñanza virtual.
From State to Province, The Ottoman Administrative Regulations in Baghdad During The 19th Century
Authors: MARUFOĞLU Sinan 
Published: June 2022

In the 19th century, while the Ottoman Empire entered a western-style modernization process in the central-provincial relations and administrative organization of the state, on the other hand, it began to fall under the political and economic influence of the industrialized European states.
Baghdad, which governed as a salyaneli province in the Ottoman administrative organization since the 16th century, has seen a series of new administrative regulations after the removal of the Governor of Baghdad, Davut Pasha in 1831 and during the implementation of the Tanzimat process and the province system.
In this study, we will emphasize the administrative changes and administrative regulations implemented by the Ottoman Empire in the 19th century in Baghdad, during and after the transition from the state system to the new province system.
Potential and Challenges for Private Sector to Lead Warung Digitalization in Indonesia
Authors: Paradizsa Irlandi , Rahayu Ety 
Published: June 2022

The purpose of this study is to understand the potential and challenges for the private sector to lead the process of warung digitalization to improve their business. MSMEs such as warung in Indonesia have been a tool for income generation for many people. Though the number of warungs that have leveled up is still minimum—most of their business are stagnant. This has resulted in their constant welfare situation. The approach used in this study is qualitative with the literature review method. This study finds that there is potential for the private sector to be the trailblazer in the digitalization process because of their characteristics and traits, the other actors’ situation, and the profit to be gained. Though, there are some challenges to be addressed, such as the lack of supporting infrastructure, minimal regulatory framework, and the need to train the warung owner.
Study of cardiotoxicity in patients with oncological pathology during chemotherapy
Authors: Melekhov S. , Gromashova E. , Tertyuk A. , Mansurova A. , Krasilnikov S. 
Published: June 2022

Background. Cardiological complications occur in 20% of all patients receiving chemotherapy for oncological diseases (the most severe are cardiac rhythm and conduction disturbances, myocardial ischemia and the development of heart failure), which complicates further high-quality antitumor therapy. In addition, 44% of all cancer patients have concomitant cardiovascular pathology, more often coronary artery disease and essential hypertension are detected. Carrying out cardiotoxic chemotherapy in this group of patients worsens the prognosis of concomitant disease.Aim. Conduct a retrospective analysis of 237 patients undergoing antitumor therapy at different stages of treatment. The analysis included those patients who received drugs with a mechanism of myocardial damage according to type 1 cardiotoxicity — doxorubicin, cyclophosphamide, Herceptin.Methods. Review of case histories of 237 patients treated in 2021 with doxorubicin (146 patients), cyclophosphamide (86 patients), Herceptin (5 patients).Results. The use of chemotherapy with the drugs listed above causes irreversible myocardial dysfunction due to the death of cardiomyocytes with the development of left ventricular dysfunction and heart failure, and also worsens the course of concomitant cardiovascular pathology in patients. For more detailed data, further research is needed, which is continuously ongoing.Conclusion. To date, the fact of the negative impact of chemotherapy on the cardiovascular system is indisputable, however, detailed studies are required. At Meshalkin National Medical Research Center, it is planned to conduct an electrocardiography, an echocardiography with an assessment of the ejection fraction, a general longitudinal strain of the left ventricle myocardium and left ventricle diastolic dysfunction, laboratory tests (troponin T and I, B-type Natriuretic Peptide (BNP), NT-proBNP) and also a comparison of these data with perfusion tomoscintigraphy of the myocardium of each patient undergoing chemotherapy treatment to identify early criteria for the development of cardiotoxicity after each cycle and at the end of chemotherapy, taking into account the total doses of drugs to obtain more accurate and up-to-date data.
Impacts of High-Fiber Snack on Satiety Hormonal Responses and Glucose
Homeostasis in Healthy Volunteers
Authors: Sunarti  , Santoso Umar , Rubi Dianandha Septiana , Cahya Pramana Abrory Agus , Huriyati Emy , Yasmine Nadia 
Published: June 2022

Background:
Dietary fiber decreases the glycemic index and produces short-chain fatty
acids (SCFAs) that will affect gastrointestinal hormone secretion, such as glucagon-like peptide-
1 (GLP-1) and peptide YY (PYY). This study investigated the effects of high-fiber snacks
on the glycemic index (GI), GLP-1, PYY, and ghrelin secretions.

Materials and Methods:
The study involved ten participants who received both 42 g of tested
snack and glucose solution as a standard by washout period for a week. The standard glucose
was prepared by dissolving 50 g of glucose powder in 200 mL of water (200 kcal), while 42 g of
snack (195.8 kcal) containing 11.70% fiber from arrowroot, pumpkin, sweet potato, and cassava.
The blood samples were collected at 0, 30, 60, 90, and 120 minutes after consuming snacks or
standard glucose.

Results:
The GI of the tested snack is 69.14, which is categorized as medium. The area under the
glucose curve of the tested snack was lower compared to standard glucose (p= <0.001), and the
plasma glucose was lower than standard glucose. Compared to standard glucose, the tested
snacks had the area under the insulin curve lower than standard glucose, but it was not statistically
significant (p= 0.082). No statistically significant difference was also found in the GLP-1,
PYY and ghrelin concentrations between both standard glucose and tested snack intervention
(p= 0.948).

Conclusion:
Our results suggest that consuming high-fiber snacks with a medium glycemic index
may have no effect on GLP-1, PYY, and ghrelin, otherwise, it could improve glucose and
insulin homeostasis.