bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
Authors: Poch Christine M. , Foo Kylie S. , De Angelis Maria Teresa , Jennbacken Karin , Santamaria Gianluca , Bähr Andrea , Wang Qing-Dong , Reiter Franziska , Hornaschewitz Nadja , Zawada Dorota , Bozoglu Tarik , My Ilaria , Meier Anna , Dorn Tatjana , Hege Simon , Lehtinen Miia L. , Tsoi Yat Long , Hovdal Daniel , Hyllner Johan , Schwarz Sascha , Sudhop Stefanie , Jurisch Victoria , Sini Marcella , Fellows Mick D. , Cummings Matthew , Clarke Jonathan , Baptista Ricardo , Eroglu Elif , Wolf Eckhard , Klymiuk Nikolai , Lu Kun , Tomasi Roland , Dendorfer Andreas , Gaspari Marco , Parrotta Elvira , Cuda Giovanni , Krane Markus , Sinnecker Daniel , Hoppmann Petra , Kupatt Christian , Fritsche-Danielson Regina , Moretti Alessandra , Chien Kenneth R. , Laugwitz Karl-Ludwig 
Published: May 2022

AbstractHeart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft crosstalk remains elusive. Here, by combining lineage tracing and single-cell transcriptomics in injured non-human primate heart biomimics, we uncover the coordinated action modes of human progenitor-mediated muscle repair. Chemoattraction via CXCL12/CXCR4 directs cellular migration to injury sites. Activated fibroblast repulsion targets fibrosis by SLIT2/ROBO1 guidance in organizing cytoskeletal dynamics. Ultimately, differentiation and electromechanical integration lead to functional restoration of damaged heart muscle. In vivo transplantation into acutely and chronically injured porcine hearts illustrated CXCR4-dependent homing, de novo formation of heart muscle, scar-volume reduction and prevention of heart failure progression. Concurrent endothelial differentiation contributed to graft neovascularization. Our study demonstrates that inherent developmental programmes within cardiac progenitors are sequentially activated in disease, enabling the cells to sense and counteract acute and chronic injury.
Comprehensive microRNA-seq transcriptomic profiling across 11 organs, 4 ages, and 2 sexes of Fischer 344 rats
Authors: Yao Xintong , Sun Shanyue , Zi Yi , Liu Yaqing , Yang Jingcheng , Ren Luyao , Chen Guangchun , Cao Zehui , Hou Wanwan , Song Yueqiang , Shang Jun , Jiang He , Li Zhihui , Wang Haiyan , Zhang Peipei , Shi Leming , Li Quan-Zhen , Yu Ying , Zheng Yuanting 
Published: May 2022

AbstractRat is one of the most widely-used models in chemical safety evaluation and biomedical research. However, the knowledge about its microRNA (miRNA) expression patterns across multiple organs and various developmental stages is still limited. Here, we constructed a comprehensive rat miRNA expression BodyMap using a diverse collection of 320 RNA samples from 11 organs of both sexes of juvenile, adolescent, adult and aged Fischer 344 rats with four biological replicates per group. Following the Illumina TruSeq Small RNA protocol, an average of 5.1 million 50 bp single-end reads was generated per sample, yielding a total of 1.6 billion reads. The quality of the resulting miRNA-seq data was deemed to be high from raw sequences, mapped sequences, and biological reproducibility. Importantly, aliquots of the same RNA samples have previously been used to construct the mRNA BodyMap. The currently presented miRNA-seq dataset along with the existing mRNA-seq dataset from the same RNA samples provides a unique resource for studying the expression characteristics of existing and novel miRNAs, and for integrative analysis of miRNA-mRNA interactions, thereby facilitating better utilization of rats for biomarker discovery.
QUaternary fault strain INdicators database - QUIN 1.0 - first release from the Apennines of central Italy
Authors: Lavecchia Giusy , Bello Simone , Andrenacci Carlo , Cirillo Daniele , Ferrarini Federica , Vicentini Noemi , de Nardis Rita , Roberts Gerald , Brozzetti Francesco 
Published: May 2022

AbstractWe present QUIN, a “QUaternary fault strain INdicators database”, designed to integrate and unify published and unpublished local-scale geological information and derive strain parameters for structural and seismotectonic analyses. It provides data on 3339 Fault Striation Pairs (FSP; fault plane and slickenline), distributed within 455 survey sites. These are exposed along the intra-Apennine Quaternary extensional faults of Central Italy. The area covers an extent of ~550 km in a NW-SE direction. We give information on FSP location, attitude and kinematics, and deformation axes. We also provide an original shapefile of the faults hosting the FSP. A large amount of homogeneously distributed Quaternary fault/slip data help to clarify and implement the contemporary geometric and kinematic deformation pattern of Central Italy that appears scattered and incomplete whenever exclusively derived from earthquake data. The high-density of structural data can help investigate stress pattern heterogeneities at local scales, with relevance for new generations of hazard assessment evaluation and a better understanding of rupture propagation and related barriers.
A deep learning based method for intelligent detection of seafarers' mental health condition
Authors: Zhen Zhu , Wang Renda , Zhu Wei 
Published: May 2022

AbstractMental health monitoring of seafarers is an important part of achieving normal development of the ocean shipping industry. In this paper, a dual subjective–objective testing scheme is proposed to achieve a more effective and intelligent assessment of seafarers' mental health status. Firstly, a new seafarers' mental health test scale (SMHT) is revised based on fuzzy factor analysis and the test data of 283 marine practitioners are analyzed using SPSS v24 software; secondly, this paper proposes an intelligent framework module for immersive subjective emotion extraction based on natural language processing, namely semantic summary extraction (SSE), speech emotion extraction (SEE), using hybrid scoring mechanism to obtain semantic and emotion matching values and assist the seafarer mental health scale to obtain the final correction score. The results showed that the assessment results of the SMHT scale exhibited good reliability (Cronbach's alpha of 0.852 $$\in (0.80{-}0.90)$$

∈
(
0.80
-
0.90
)

and retest reliability R of $$0.873\in (0.85{-}0.90)$$

0.873
∈
(
0.85
-
0.90
)

) and scale association validity (for SCL-90, ($$\text{r}= 0.468{-}0.841)>0.45$$

r
=
0.468
-
0.841
)
>
0.45

). In addition, the calibration rate of the subject-object dual test method was improved by approximately 12.05% compared to the traditional mental health scale. Finally, the advantages and disadvantages of this solution were compared with mental health testing techniques such as CAT, machine learning, SCL-90, and fMRI, and the method demonstrated more accurate psychological testing results, providing a simple and intelligent solution for standardized psychological testing of seafarers.
Coat protein of partitiviruses isolated from mycorrhizal fungi functions as an RNA silencing suppressor in plants and fungi
Authors: Shimura Hanako , Kim Hangil , Matsuzawa Akihiko , Akino Seishi , Masuta Chikara 
Published: May 2022

AbstractOrchid seeds depend on colonization by orchid mycorrhizal (OM) fungi for their germination; therefore, the orchids and OM fungi have long maintained a close relationship (e.g., formation of the hyphal mass structure, peloton) during their evolution. In the present study, we isolated new partitiviruses from OM fungi; partitivirus were separately found in different subcultures from the same fungi. Partitiviruses have been believed to lack an RNA silencing suppressor (RSS), which is generally associated with viral pathogenicity, because most partitiviruses isolated so far are latent in both plants and fungi. However, we found that the coat protein (CP) of our partitiviruses indeed had RSS activity, which differed among the virus isolates from OM fungi; one CP showed RSS activity in both plants and fungi, while another CP showed no activity. The family Partitiviridae include viruses isolated from plants and fungi, and it has been suggested that these viruses may occasionally be transmitted between plant and fungal hosts. Given that there are several reports showing that viruses can adapt to nonhost using strong RSS, we here discussed the idea that partitiviruses may be better able to migrate between the orchid and fungus probably through the pelotons formed in the orchid cells, if host RNA silencing is suppressed by partitivirus RSS.
Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease
Authors: Jang Eunkyeong , Park Minju , Jeong Ji Eun , Lee Ji Young , Kim Myeong Gyu 
Published: May 2022

AbstractThis study aimed to detect safety signals of rebamipide and search for adverse events (AEs) of rebamipide that are more common than those of other drugs for peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) in the elderly population. A total of 101,735 AE reports for drugs used to treat PUD and GERD between 2009 and 2018 from the KIDS-KAERS database (KIDS-KD) were used. Disproportionality analysis was performed to calculate the proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). Drug labels in Korea, Japan, and China were reviewed to identify signals that have been listed. AEs frequently reported in the elderly population were also analyzed. Seriousness and median time to AEs were evaluated for statistically significant AEs. A total of 14 signals were detected, and 4 signals (dry mouth, dermatitis, purpura/petechia, and fluid overload) were not listed on drug labels; however, they may be included as part of other listed AEs. In the elderly population, 11 AEs such as dyspepsia/indigestion/gastrointestinal distress, somnolence, dry mouth, and edema were common. These AEs were not serious and occurred within 2–9 days. This study identified possible AEs of rebamipide, a relatively safe drug.
Long use of continuous positive airway pressure protects against the development of treatment-requiring retinopathy of prematurity
Authors: Suga Shutaro , Kyono Yuki , Kido Takumi , Nakasone Ruka , Abe Shinya , Ashina Mariko , Nozu Kandai , Fujioka Kazumichi 
Published: May 2022

AbstractAlthough preterm infant mortality is low, the proportion of patients with treatment-requiring retinopathy of prematurity (TR-ROP) is high in Japan. Various multicenter studies have reported the risk factors for TR-ROP; however, no large-scale studies have been conducted in Japan. We retrospectively analyzed 13,645 infants born at < 28 weeks’ gestation (January 1, 2009–December 31, 2018), and registered in the Neonatal Research Network of Japan database. TR-ROP was defined as ROP requiring retinal laser photocoagulation and/or intravitreal anti-vasoendothelial growth factor drugs. Multivariable logistic regression analysis was performed to identify factors associated with TR-ROP development. The median gestational age of enrolled infants was 26 weeks (interquartile range [IQR], 24–27 weeks), median birth weight was 760 g (IQR, 620–918 g). Proportion of patients with TR-ROP was 30.3%. TR-ROP was significantly associated with birth at < 26 weeks’ gestational age (adjusted odds ratio [aOR] 1.54), blood transfusion (aOR 1.49), invasive ventilation ≥ 28 days (aOR 1.41), sepsis (aOR 1.29), birth weight < 750 g (aOR 1.28), intraventricular hemorrhage (aOR 1.33), delayed achievement of full enteral feeding > 14 days (aOR 1.28), and continuous positive airway pressure (CPAP) therapy ≥ 28 days (aOR 0.79). Supplemental oxygen ≥ 28 days was not associated with TR-ROP development. Lower gestational age at birth and birth weight, blood transfusion, prolonged invasive ventilation, sepsis, intraventricular hemorrhage, and delayed achievement of full enteral feeding were risk factors for TR-ROP, whereas CPAP use was protective against TR-ROP.
A fully probabilistic control framework for stochastic systems with input and state delay
Authors: Herzallah Randa , Zhou Yuyang 
Published: May 2022

AbstractThis paper proposes a unified probabilistic control framework for a class of stochastic systems with both control input and state time delays. Both of the stochastic nature and time delays in the system dynamics are considered simultaneously, thus providing a comprehensive and rigorous control methodology. The problem is formulated in a fully probabilistic framework, where the system dynamics and its controller are fully characterised by arbitrary probabilistic models. In this framework, the Kullback–Leibler Divergence between the actual joint probability density function of the system dynamics and controller and a predefined ideal joint probability density function is used to characterise the discrepancy between the two distributions and derive the randomised controller. Time delays in the control input and system state are taken into consideration in the optimisation process for the derivation of the optimal randomised controller. Besides, the analytic control solution of the time delay fully probabilistic control problem for a class of linear Gaussian stochastic systems is derived while the successive approximation approach is implemented to deal with the time-advanced components in the control law that result from the existence of time delays. The effectiveness of the proposed control framework is then illustrated on a numerical example and a real-world example.
Predictors of stress among dentists during the COVID-19 epidemic
Authors: Wójcik Dorota , Kutnik Jan , Szalewski Leszek , Borowicz Janusz 
Published: May 2022

AbstractThe aim of the study was to assess the relationship between personality traits, self-esteem and life satisfaction, and also the stress level, among dentists during the COVID-19 outbreak. In order to confirm our hypotheses, 310 active dentists aged 25–64 years who were practising during the first wave of COVID-19 in Poland were examined. The IPIP-BFM-20 self-report questionnaire was used to measure personality traits, the popular Rosenberg Self-Esteem Scale was used to assess self-esteem, the five-item Satisfaction with Life Scale was used to measure life satisfaction and the four-item version of the Perceived Stress Scale was used to measure stress. The dependent variable—stress—correlates negatively with traits in relation to the dimensions of extraversion (r = −0.17, p < 0.01), emotional stability (r = −0.35, p < 0.01) and intellect (r = −0.16, p < 0.01); it also has a negative correlation with self-esteem (r = −0.37, p < 0.01) and life satisfaction (r = −0.35, p < 0.01). Among the analysed variables, the highest correlations are observed for the following: self-esteem and emotional stability (r = 0.51, p < 0.01); self-esteem and life satisfaction (r = 0.49, p < 0.01); extraversion and intellect (r = 0.47, p < 0.01). Considering the measures of mediation relevance and pathway relevance, it can be assumed that both self-esteem and life satisfaction have a mediating function in the relationship between agreeableness, emotional stability and stress: the relationship between emotional stability and stress is negative whereas that between agreeableness and stress is positive.
Contrast-enhanced ultrasound (CEUS) in characterization of inconclusive cervical lymph nodes: a meta-analysis and systematic review
Authors: Spiesecke Paul , Neumann Konrad , Wakonig Katharina , Lerchbaumer Markus H. 
Published: May 2022

AbstractLymph node metastases are common in malignant neoplasms of head and neck. Since cervical lymph nodes (cLN) are localized superficially, ultrasound (US) represents the primary imaging modality. The aim of the study is to report the value of US and contrast-enhanced ultrasound (CEUS) and their diagnostic confidence in the characterization of inconclusive cLN. A systematic review was performed using the literature data base PubMed. Results were filtered (published in a peer-reviewed journal, full-text available, published within the last ten years, species human, English or German full-text) and inclusion criteria were clearly defined (cohort with lymphadenopathy or malignancy in head and neck ≥ 50 patients, histological confirmation of malignant imaging findings, performance of CEUS as outcome variable). The results were quantified in a meta-analysis using a random-effects model. Overall, five studies were included in qualitative and quantitative analysis. The combination of non-enhanced US and CEUS enlarges the diagnostic confidence in the characterization of lymph nodes of unclear dignity. The pooled values for sensitivity and specificity in the characterization of a malignant cervical lymph node using US are 76% (95%-CI 66–83%, I2 = 63%, p < 0.01) and 80% (95%-CI 45–95%, I2 = 92%, p < 0.01), compared to 92% (95%-CI 89–95%, I2 = 0%, p = 0.65) and 91% (95%-CI 87–94%, I2 = 0%, p = 0.40) for the combination of US and CEUS, respectively. Consistent results of the included studies show improved diagnostic performance by additional CEUS. Nevertheless, more prospective studies are needed to implement CEUS in the diagnostic pathway of cLN.
Circulating neurofilament is linked with morbid obesity, renal function, and brain density
Authors: Rebelos Eleni , Rissanen Eero , Bucci Marco , Jääskeläinen Olli , Honka Miikka-Juhani , Nummenmaa Lauri , Moriconi Diego , Laurila Sanna , Salminen Paulina , Herukka Sanna-Kaisa , Singhal Tarun , Nuutila Pirjo 
Published: May 2022

AbstractNeurofilament light chain (NfL) is a novel biomarker reflecting neuroaxonal damage and associates with brain atrophy, and glial fibrillary acidic protein (GFAP) is a marker of astrocytic activation, associated with several neurodegenerative diseases. Since obesity is associated with increased risk for several neurodegenerative disorders, we hypothesized that circulating NfL and GFAP levels could reflect neuronal damage in obese patients. 28 morbidly obese and 18 lean subjects were studied with voxel based morphometry (VBM) MRI to assess gray and white matter densities. Serum NfL and GFAP levels were determined with single-molecule array. Obese subjects were re-studied 6 months after bariatric surgery. Morbidly obese subjects had lower absolute concentrations of circulating NfL and GFAP compared to lean individuals. Following bariatric surgery-induced weight loss, both these levels increased. Both at baseline and after weight loss, circulating NfL and GFAP values correlated inversely with eGFR. Cross-sectionally, circulating NfL levels correlated inversely with gray matter (GM) density, and this association remained significant also when accounting for age and total eGFR. GFAP values did not correlate with GM density. Our data suggest that when determining circulating NfL and GFAP levels, eGFR should also be measured since renal function can affect these measurements. Despite the potential confounding effect of renal function on NfL measurement, NfL correlated inversely with gray matter density in this group of subjects with no identified neurological disorders, suggesting that circulating NfL level may be a feasible biomarker of cerebral function even in apparently neurologically healthy subjects.
An evolutionary model and classification scheme for nephrite jade based on veining, fabric development, and the role of dissolution–precipitation
Authors: Tarling Matthew S. , Smith Steven A. F. , Negrini Marianne , Kuo Li-Wei , Wu Wei-Hsin , Cooper Alan F. 
Published: May 2022

AbstractAlthough nephrite jade has been collected and treasured since the Stone Age, we lack a clear understanding of how it forms during deformation and metasomatism in shear zones. Using microstructural analysis of samples from Taiwan, California, and New Zealand, we propose a conceptual model for the evolution of nephrite jade that distinguishes four nephrite types based on mode of formation and textural characteristics: (1) primary (type 1a) or folded (type 1b) vein nephrite, (2) crenulated nephrite (type 2), (3) foliated semi-nephrite (type 3), and (4) nodular or domainal nephrite (type 4). We interpret the texture of our analysed samples to represent snapshots of a progressive textural evolution similar to that experienced by other deformed and fine-grained metamorphic rocks that develop under fluid-present, greenschist-facies conditions. Our observations suggest that types 2 and 3 nephrite can evolve from vein nephrite (type 1) by the development of crenulated and foliated metamorphic fabrics, during which the most important deformation process is dissolution–precipitation. However, development of metamorphic fabrics can be interrupted by transient brittle deformation, leading to the formation of type 4 nephrite that is characterised by nodular or angular clasts of nephrite in a nephritic matrix.
Astaxanthin improves the development of the follicles and oocytes through alleviating oxidative stress induced by BPA in cultured follicles
Authors: Li Yaqiu , Dong Zhu , Liu Sitong , Gao Fan , Zhang Jinyu , Peng Zhendong , Wang Lixin , Pan Xiaoyan 
Published: May 2022

AbstractThis study is to investigate whether astaxanthin could alleviate the oxidative stress damages of follicles induced by BPA and improve the development of the cultured follicles and oocytes. Compared with BPA group, the survival rate, antrum formation rate, oocyte maturation rate and adherence area of the D8 and D10 follicles of the BPA+Asta group were significantly higher. The estrogen and progesterone in the culture medium of BPA+Asta group were significantly higher. PCNA in D8 and D10 granulosa cells and ERα in D10 granulosa cells of follicles in BPA+Asta group were significantly higher. The levels of malondialdehyde in the follicle culture medium, levels of ROS in the oocytes, the expression levels of caspase 3 and cathepsin B in the oocytes of the BPA+Asta group were significantly lower. However, the mitochondrial membrane potential, and the expression levels of antioxidant genes (CAT, SOD1 and SOD2) and anti-apoptotic gene Bcl-2 in the oocytes in the BPA+Asta group were significantly higher. Astaxanthin improves the development of follicles and oocytes through increasing the antioxidant capacity of follicles and oocytes, and relieving the BPA-induced oxidative stress during follicular development and oocyte maturation.