bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of essential oils and phytochemicals against the mycotoxins producing fungi for shelf‐life enhancement and food preservation
Authors: Kumar Pradeep , Mahato Dipendra Kumar , Gupta Akansha , Pandhi Shikha , Mishra Sadhna , Barua Sreejani , Tyagi Vidhi , Kumar Arvind , Kumar Manoj , Kamle Madhu 
Published: January 2022

SummaryMycotoxin‐producing fungi are a significant source of crop and food contamination, posing a significant threat to global food safety and security. Essential oils, plant extracts and phytochemicals have emerged as green preservatives to extend the shelf‐life of foods due to their unique antimicrobial properties. Unlike conventional synthetic preservatives, they are a sustainable and safe way to preserve food with no or little harmful effects on the environment. Use of nanoformulations containing essential oils and phytochemicals offer enormous potential as a mitigation strategy to lower mycotoxin contamination incidences in food and crop with enhanced release behaviour to efficiently transport them to the target location for a rapid reaction without much impact from environmental variables. Hence, this review overviews various essential oils and phytochemicals utilized through nanoformulations to control the mycotoxigenic fungi, probable mechanism of actions involved as well as emerging mycotoxins and associated safety concerns to ensure food sustainability.
Psychiatric comorbidity associated with weight status in 9 to 10 year old children
Authors: Smith Kathryn E. , Mason Tyler B. 
Published: January 2022

SummaryBackgroundPaediatric overweight and obesity (OW/OB) constitute a serious public health concern. Given that psychological problems may be key contributors to the onset and maintenance of paediatric obesity, the present study examined past and current psychiatric comorbidities across the weight spectrum during middle childhood among a nationally representative sample.MethodsParticipants were 11 708 9‐ to 10‐year‐old children (31.6% with OW/OB) and their caregivers who participated in the first wave of data collection in the Adolescent Brain Cognitive Development (ABCD) study. Logistic regressions were used to examine the association between weight status (i.e., underweight, healthy weight, OW, OB) and likelihood of current/past psychiatric diagnoses.ResultsCompared to healthy weight children, those with OW/OB were more likely to have current/past major depressive disorder and binge eating disorder. Relative to healthy weight children, those with OB were more likely to have prior separation anxiety disorder, current specific phobia and oppositional defiant disorder; those with OW were more likely to have PTSD; and those with underweight were more likely to have ADHD.ConclusionsResults suggest cross‐sectional associations among negative emotionality, binge eating, and OW/OB, and highlight the need for ongoing prospective research to investigate directionality of associations and mechanisms of effects.
Habla conmigo, daddy! Fathers’ language input in North American bilingual Latinx families
Authors: Ferjan Ramírez Naja , Hippe Daniel S. , Correa Lili , Andert Josephine , Baralt Melissa 
Published: January 2022

AbstractThis study examines the language environments of bilingually raised Latinx infants (n = 37) in mother–father families of diverse socioeconomic backgrounds, with a focus on paternal parentese, a speaking style distinguished by higher pitch, slower tempo, and exaggerated intonation. Two daylong audio recordings were collected on weekends, when both parents were at home. Paternal, maternal, and infant speech variables were quantified through automatic and manual analyses. Most infants experienced Spanish and English within child‐directed speech, and language mixing was common in mothers and fathers. Adjusting for demographic variables, infants heard 50.4% less talk from men compared to women, and 43.4% less parentese from fathers compared to mothers. However, when controlling for overall speech amount, the rate of parentese use did not differ between mothers and fathers, demonstrating that, contrary to the stereotype, fathers in Latinx families adjust their speech in verbal interactions with their infants. An asymmetry emerged, where paternal parentese was associated with paternal knowledge of language development but not with paternal involvement in childcare responsibilities; the opposite was true for paternal speech amount. Controlling for maternal contributions, paternal parentese was predictive of concurrent parent–infant turn‐taking and infant language vocalizations, demonstrating its important role in infant language development.
Selection of Debaryomyces hansenii isolates as starters in meat products based on phenotypic virulence factors, tolerance to abiotic stress conditions and aroma generation
Authors: Belloch Carmela , Perea-Sanz Laura , Gamero Amparo , Flores Monica 
Published: January 2022

Abstract

Introduction
Debaryomyces hansenii is a yeast widely used in meat fermentations as starter for the purpose of improving the aromatic quality of the final product. However, it has not been the subject of an extensive study regarding phenotypic characteristics important for starter selection, such as the capacity to grow at abiotic stress conditions occurring during fermentation, the ability to generate desirable aromas and the absence of virulence traits in yeasts.

Aims
The aim of this study was to screen 60 strains of D. hansenii isolated from assorted foods for their potential application as starters in dry-cured fermented sausages manufacture.

Methods
The abiotic stress factors tested were low aw and pH and high concentration of salt, acetic acid and lactic acid. The phenotypic virulence traits explored were growth at 37°C, pseudohyphal and biofilm generation, invasiveness and enzymatic activities present in virulent yeasts. The generation of desirable meat aromas was tested in models containing aroma precursors applying an olfactory analysis. A quantitative profiling of stress tolerance was used to test the potential performance of selected strains in meat fermentations.

Results
The results demonstrated that most strains displayed no virulence trait or were only positive for biofilm production. Moreover, the strains showed large heterogeneity regarding their tolerance to abiotic stress factors, although most of them could grow at intermediate to high levels of the traits. The sensory analysis was the criteria determining the selection of starter strains.

Conclusions
The evaluation of the phenotypic traits demonstrates that D. hansenii is a safe yeast, it is able to tolerate the stress in meat fermentation and it is able to generate desirable aromas.

Significance and Impact of the Study
The results of this study confirm the adequacy of selected D. hansenii strains to be applied as starters in meat products.
Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non‐alcoholic fatty liver disease
Authors: Baumann Anja , Rajcic Dragana , Brandt Annette , Sánchez Victor , Jung Finn , Staltner Raphaela , Nier Anika , Trauner Michael , Staufer Katharina , Bergheim Ina 
Published: January 2022

AbstractChanges in intestinal nitric oxide metabolism are discussed to contribute for the development of intestinal barrier dysfunction in non‐alcoholic fatty liver disease (NAFLD). To induce steatosis, female C57BL/6J mice were pair‐fed with a liquid control diet (C) or a fat‐, fructose‐ and cholesterol‐rich diet (FFC) for 8 weeks. Mice received the diets ± 2.49 g L‐arginine/kg bw/day for additional 5 weeks. Furthermore, mice fed C or FFC ± L‐arginine/kg bw/day for 8 weeks were concomitantly treated with the arginase inhibitor Nω‐hydroxy‐nor‐L‐arginine (nor‐NOHA, 0.01 g/kg bw). Liver damage, intestinal barrier function, nitric oxide levels and arginase activity in small intestine were assessed. Also, arginase activity was measured in serum from 13 patients with steatosis (NAFL) and 14 controls. The development of steatosis with beginning inflammation was associated with impaired intestinal barrier function, increased nitric oxide levels and a loss of arginase activity in small intestine in mice. L‐arginine supplementation abolished the latter along with an improvement of intestinal barrier dysfunction; nor‐NOHA attenuated these effects. In patients with NAFL, arginase activity in serum was significantly lower than in healthy controls. Our data suggest that increased formation of nitric oxide and a loss of intestinal arginase activity is critical in NAFLD‐associated intestinal barrier dysfunction.
Improving ready‐to‐eat apple cubes' safety using chitosan‐based active coatings
Authors: Bambace Maria Florencia , Moreira Maria del Rosario 
Published: January 2022

AbstractThe use of active coatings is shown as an option to offer safe ready‐to‐eat fruits and respond the growing demand of consumers for fresh, environmentally friendly and products free from chemical preservatives. In this work, chitosan (Ch), chitosan + vanillin (Ch‐V), and chitosan + geraniol (Ch‐G) coatings were applied on apple cubes to evaluate their microbiological quality for 12 days of refrigerated storage. All combinations applied demonstrated significant bactericidal effects on native microbiota, resulting in number of mesophilics, psychrotrophics, and yeasts and molds under the detection limit (<2.00 log) immediately after coating and during 12 days for most of them. Moreover, Escherichia coli O157:H7 and Listeria innocua artificially inoculated on apple cubes showed great reductions after coating treatments, exerting vanillin or geraniol enriched coatings outstanding antimicrobial activity. In fact, after 12 days of refrigerated storage, apple cubes treated with vanillin and geraniol (>2.00 log CFU/g) showed reductions in E. coli O157:H7 counts greater than 2.00 log in comparison with the control (4.68 log CFU/g). The preliminary results of this study demonstrated that Ch, Ch‐Va, and Ch‐Ge could be an interesting alternative to improve the safety of apple cubes and, therefore, a novel option to offer safe, ready‐to‐eat apple to consumers.
Water stress resilient cereal crops: Lessons from wild relatives
Authors: Toulotte Justine M. , Pantazopoulou Chrysoula K. , Sanclemente Maria Angelica , Voesenek Laurentius A. C. J. , Sasidharan Rashmi 
Published: January 2022

AbstractCereal crops are significant contributors to global diets. As climate change disrupts weather patterns and wreaks havoc on crops, the need for generating stress‐resilient, high‐yielding varieties is more urgent than ever. One extremely promising avenue in this regard is to exploit the tremendous genetic diversity expressed by the wild ancestors of current day crop species. These crop wild relatives thrive in a range of environments and accordingly often harbor an array of traits that allow them to do so. The identification and introgression of these traits into our staple cereal crops can lessen yield losses in stressful environments. In the last decades, a surge in extreme drought and flooding events have severely impacted cereal crop production. Climate models predict a persistence of this trend, thus reinforcing the need for research on water stress resilience. Here we review: (i) how water stress (drought and flooding) impacts crop performance; and (ii) how identification of tolerance traits and mechanisms from wild relatives of the main cereal crops, that is, rice, maize, wheat, and barley, can lead to improved survival and sustained yields in these crops under water stress conditions.
Ca2+ signaling in plant responses to abiotic stresses
Authors: Dong Qiuyan , Wallrad Lukas , Almutairi Bader O. , Kudla Jörg 
Published: January 2022

AbstractAdverse variations of abiotic environmental cues that deviate from an optimal range impose stresses to plants. Abiotic stresses severely impede plant physiology and development. Consequently, such stresses dramatically reduce crop yield and negatively impact on ecosystem stability and composition. Physical components of abiotic stresses can be, for example, suboptimal temperature and osmotic perturbations, while representative chemical facets of abiotic stresses can be toxic ions or suboptimal nutrient availability. The sheer complexity of abiotic stresses causes a multitude of diverse components and mechanisms for their sensing and signal transduction. Ca2+, as a versatile second messenger, plays multifaceted roles in almost all abiotic stress responses in that, for a certain abiotic stress, Ca2+ is not only reciprocally connected with its perception, but also multifunctionally ensures subsequent signal transduction. Here, we will focus on salt/osmotic stress and responses to altered nutrient availability as model cases to detail novel insights into the identity of components that link stress perception to Ca2+ signal formation as well as on new insights into mechanisms of Ca2+ signal implementation. Finally, we will deduce emerging conceptual consequences of these novel insights and outline arising avenues of future research on the role of Ca2+ signaling in abiotic stress responses in plants.
Healthcare cost by primary tumour, functioning status and treatment among patients with metastatic neuroendocrine tumours: The LyREMeNET study
Authors: Perrier Marine , Polazzi Stéphanie , Lemelin Annie , Fernandez Violaine , Labonne Stéphanie , Maucort‐Boulch Delphine , Lombard‐Bohas Catherine , Duclos Antoine , Walter Thomas 
Published: January 2022

AbstractThe annual prevalence of metastatic neuroendocrine tumours (mNETs) is rising, leading to significant healthcare costs. The present study aimed to describe healthcare resource use (HRU) and the corresponding costs among patients with mNETs, according to primary tumour location, functioning status and type of treatments. The LyREMeNET study included consecutive mNET patients with a diagnosis performed between January 2010 and December 2017, who were seen at least once in the ENETS center of excellence in Lyon. The median HRU and costs per patient were estimated, up to 3 years before and after the diagnosis. The Cancer database of the center was linked to the French national health data system. HRU and related costs were described per person per month (PPPM). Among 316 patients presenting with a mNET, 48.4% had a small‐intestinal mNET, 32.3% had a pancreatic mNET and 39.2% had carcinoid syndrome. The mean overall cost increased from €615 to €2875 PPPM between the years preceding and following the diagnosis, and remained above €2500 in the two subsequent years. The two main cost drivers of total healthcare expenditure were drugs (€1161) and hospital stay (€662). Median costs of mNETs arising from pancreas and small intestine were €2325 and €2540 PPPM, respectively. Costs were higher in patients with a functional mNET (€2807 PPPM for carcinoid syndrome) and during peptide receptor radionuclide therapy (PRRT) (€8835 PPPM). The highest overall cost was found during the first year following the diagnosis. Cost of care was higher for small intestine mNETs, for functional mNETs and during peptide receptor radionuclide therapy.
Meta‐analysis of platelet‐rich plasma therapy for anal fistula
Authors: Luo Qinghua , Zhou Ping , Chang Shuangqing 
Published: January 2022

AbstractObjectiveTo systematically evaluate the efficacy of platelet‐rich plasma (PRP) in treating anal fistula.MethodsPubMed, EMBASE, and Cochrane Library databases were systematically searched for randomized controlled studies (RCTs) and case‐control studies published before June 2021 on evaluating the efficacy of platelet‐rich plasma (PRP) in treating anal fistula. References of the journals were manually searched for relevant studies. Literature search, screening, data extraction, and bias assessment were carried out by two researcher independently. Stata13.0 and RevMan 5.3 software were used for statistical analysis of the cure rate and recurrence rate of anal fistula.ResultsA total of 6 case‐control studies and 3 RCTs involving 289 patients were included. Meta‐analysis showed that the pooled cure rate of all studies was 65% (95% CI 0.53–0.77), p = 0.000, and the pooled recurrence rate of all studies was 12% (95% CI 0.08–0.17).ConclusionPlatelet‐rich plasma is safe and effective in treating anal fistula and should be promoted and further studied in clinical practice.
Vaccinium myrtillus L. extract associated with octocrylene, bisoctrizole, and titanium dioxide: in vitro and in vivo tests to evaluate safety and efficacy
Authors: Ruscinc Nadia , Morocho‐Jácome Ana Lucía , Martinez Renata Miliani , Magalhães Wagner Vidal , Escudeiro Cassiano Carlos , Giarolla Jeanine , Rosado Catarina , Velasco Maria Valéria Robles , Baby André Rolim 
Published: January 2022

AbstractObjectiveThe harmful effects induced by ultraviolet exposition and the significant increment in skin cancer diagnosis confirm the necessity to develop effective and safe sunscreens. Limited efficacy and cutaneous adverse reactions of traditional formulations drove the incorporation of natural extracts into multifunctional sunscreens. Vaccinium myrtillus L. extract (VME), that contains anthocyanins and flavonoids, is a potential candidate for such systems.MethodsConsidering that, we performed in vitro and in vivo tests to evaluate the sun protection factor (SPF), photostability, and safety of sunscreen samples containing VME.ResultsAs main results, the SPF was reduced in both in vitro and in vivo evaluation in the presence of VME; nonetheless, the samples were photostable and safe.ConclusionFurther investigation is required to better understand the unexpected effects of VME over photoprotection, decreasing the SPF value. As a conclusion, even with interesting findings, we highlight the importance of case‐by‐case investigations to develop multifunctional bioactive sunscreens.
Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
Authors: Durand Alexane , Keenihan Erin , Schweizer Daniela , Maiolini Arianna , Guevar Julien , Oevermann Anna , Gutierrez‐Quintana Rodrigo 
Published: January 2022

AbstractBackgroundLymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking.ObjectiveDescribe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (PNS) nervous system or both in cats.AnimalsThirty‐one cats with confirmed cytological or histopathological diagnosis or both of lymphoma involving the CNS or PNS or both, and MRI findings of the lesions.MethodsMulticenter retrospective descriptive study. Signalment and medical information were recorded. Magnetic resonance imaging findings were reviewed by 3 observers following a list of predefined criteria and consensus was sought. Frequency distributions of the different categorical data were reported.ResultsMedian duration of clinical signs at time of presentation was 14 days (range, 1‐90). Neurological examination was abnormal in 30/31 cats. On MRI, lesions affecting the CNS were diagnosed in 18/31 cats, lesions in both CNS and PNS in 12/31, and lesions in the PNS only in 1/31. Intracranial lesions were diagnosed in 22 cats (extra‐axial, 7/22; intra‐axial, 2/22; mixed, 13/22), and spinal lesions were diagnosed in 12 (6/12 involving the conus medullaris and lumbosacral plexuses). Infiltration of adjacent extra‐neural tissue was present in 11/31 cases. Contrast enhancement was seen in all lesions, being marked in 25/30. Meningeal enhancement was present in all but 2 cases. Several distinct MRI patterns were observed.Conclusions and Clinical ImportanceNervous system lymphoma in cats has a wide range of MRI features, of which none is pathognomonic. However, together with clinical data and cerebrospinal fluid (CSF) analysis, MRI may provide a strong tentative antemortem diagnosis.
Effect of early or late blood sampling on thyrotropin releasing hormone stimulation test results in horses
Authors: Thane Kristen , Uricchio Cassandra , Frank Nicholas 
Published: January 2022

AbstractBackgroundDiagnosis of pituitary pars intermedia dysfunction (PPID) using the thyrotropin‐releasing hormone (TRH) stimulation test requires blood collection 10 minutes after TRH injection; it is unknown if small differences in timing affect test results.ObjectiveTo determine whether early or late sampling results in a significant (≥10%) difference in plasma adrenocorticotropic hormone (ACTH) concentration compared to standard 10‐minute sampling.AnimalsTwenty‐four healthy adult horses with unknown PPID status.MethodsIn this prospective study, subjects underwent a single TRH stimulation test, with blood collected exactly 9 minutes (early), 10 minutes (standard), and 11 minutes (late) after injection. ACTH was measured by chemiluminescent immunoassay. Two aliquots of the 10‐minute plasma sample were analyzed separately to assess intra‐assay variability. Data were reported descriptively and bias was calculated using Bland‐Altman plots. Significance was set at P = .05.ResultsMinor variability was observed between the paired 10‐minute sample aliquots (range, 0%‐6%; median 3%). Overall variability of early or late samples compared to the corresponding paired (average) 10‐minute standard concentration ranged from 0% to 92% (median 10%). Seventy‐five percent of horses (18/24) tested had at least 1 early or late reading that differed by ≥10% from its corresponding 10‐minute standard concentration, and 21% of horses (5/24) would have a different interpretation of testing result with either early or late sampling. Incidence of ≥10% variability was independent of PPID status (P = .59).Conclusions and Clinical ImportancePrecise timing of sample collection is critical to ensure accurate assessment of PPID status given the observation of significant variability associated with minor alterations in timing of sample collection.
A reappraisal of Katona’s adaptive theory of consumer behaviour using U.K. data
Authors: Gausden Robert , Hasan Mohammad 
Published: January 2022

AbstractThe objective of this paper is to conduct a reappraisal of Katona's (1968) adaptive theory of consumer behaviour, which maintains that discretionary consumption is partly determined by attitudes and expectations of households. Initially, using UK data, we follow Katona by empirically examining whether changes in personal expenditure on durable goods are connected to earlier movements in consumer confidence. Evidence of a lack of a stable relationship between these two variables encourages us to perform a disaggregated analysis involving 111 components of four different forms of consumption, which enables construction of an aggregate measure of discretionary spending. We find that sufficient criteria are satisfied for the sentiment index to be accepted as a reliable predictor of the growth of gratuitous expenditure. In conclusion, then, it would seem that the validity of Katona's theory can be revived if we are prepared to discard the assumption that durable goods’ consumption is synonymous with discretionary spending.
Immigration, language and disadvantage
Authors: Shorten Andrew 
Published: January 2022

AbstractMany democratic states provide supports for immigrants who are not fluent speakers of the majority or official language(s). For example, they provide interpreters in courts and hospitals, print administrative forms in multiple languages and employ bilingual staff to provide public services. This paper considers the justification of these policies from the perspective of normative political theory, makes some recommendations about what they ought to consist in and identifies some of their limitations. It argues that instead of appealing to rights, the best justification for these measures has to do with empowering immigrants and enhancing their capabilities. However, although some disadvantages experienced by immigrants for linguistic reasons can be reduced or even eliminated by public policy measures, some important ones cannot. Novel grounds are thus proposed in support of immigrant‐receiving societies having a duty to provide meaningful opportunities to learn the majority or official language(s).