bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Repeat Vaccination on Immunogenicity of Quadrivalent Cell-Culture and Recombinant Influenza Vaccines Among Healthcare Personnel Aged 18–64 Years: A Randomized, Open-Label Trial
Authors: Gaglani Manjusha , Kim Sara S , Naleway Allison L , Levine Min Z , Edwards Laura , Murthy Kempapura , Dunnigan Kayan , Zunie Tnelda , Groom Holly , Ball Sarah , Jeddy Zuha , Hunt Danielle , Wesley Meredith G , Sambhara Suryaprakash , Gangappa Shivaprakash , Grant Lauren , Cao Weiping , Gross F Liaini , Mishina Margarita , Fry Alicia M , Thompson Mark G , Dawood Fatimah S , Flannery Brendan 
Published: August 2022

Abstract

Background
Antibody responses to non–egg-based standard-dose cell-culture influenza vaccine (containing 15 µg hemagglutinin [HA]/component) and recombinant vaccine (containing 45 µg HA/component) during consecutive seasons have not been studied in the United States.

Methods
In a randomized trial of immunogenicity of quadrivalent influenza vaccines among healthcare personnel (HCP) aged 18–64 years over 2 consecutive seasons, HCP who received recombinant-HA influenza vaccine (RIV) or cell culture–based inactivated influenza vaccine (ccIIV) during the first season (year 1) were re-randomized the second season of 2019–2020 (year 2 [Y2]) to receive ccIIV or RIV, resulting in 4 ccIIV/RIV combinations. In Y2, hemagglutination inhibition antibody titers against reference cell–grown vaccine viruses were compared in each ccIIV/RIV group with titers among HCP randomized both seasons to receive egg-based, standard-dose inactivated influenza vaccine (IIV) using geometric mean titer (GMT) ratios of Y2 post-vaccination titers.

Results
Y2 data from 414 HCP were analyzed per protocol. Compared with 60 IIV/IIV recipients, 74 RIV/RIV and 106 ccIIV/RIV recipients showed significantly elevated GMT ratios (Bonferroni corrected P &lt; .007) against all components except A(H3N2). Post-vaccination GMT ratios for ccIIV/ccIIV and RIV/ccIIV were not significantly elevated compared with IIV/IIV except for RIV/ccIIV against A(H1N1)pdm09.

Conclusions
In adult HCP, receipt of RIV in 2 consecutive seasons or the second season was more immunogenic than consecutive egg-based IIV for 3 of the 4 components of quadrivalent vaccine. Immunogenicity of ccIIV/ccIIV was similar to that of IIV/IIV. Differences in HA antigen content may play a role in immunogenicity of influenza vaccination in consecutive seasons.

Clinical Trials Registration
NCT03722589.
Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life
Authors: Nelson Bryan S , Tierney Camlin , Persaud Deborah , Jao Jennifer , Cotton Mark F , Bryson Yvonne , Coletti Anne , Ruel Theodore D , Spector Stephen A , Reding Christina , Bacon Kira , Costello Diane , Perlowski Charlotte , Santos Cruz Maria Leticia , Kosgei Josphat , Majji Sai , Yin Dwight E , Jean-Philippe Patrick , Chadwick Ellen G ,   for the IMPAACT P1115 Team
Published: August 2022

Abstract

We followed 54 infants with in utero HIV after initiating very early antiretroviral treatment. At weeks 24 and 48, ≥80% had CD4 ≥1500 cells/mm3 and CD4% ≥25%. Routine Pneumocystis jirovecii pneumonia prophylaxis in the first year of life may not be necessary for all very early treated infants.

Clinical Trials Registration
NCT02140255.
UMIErrorCorrect and UMIAnalyzer: Software for Consensus Read Generation, Error Correction, and Visualization Using Unique Molecular Identifiers
Authors: Österlund Tobias , Filges Stefan , Johansson Gustav , Ståhlberg Anders 
Published: August 2022

Abstract

Background
Targeted sequencing using unique molecular identifiers (UMIs) enables detection of rare variant alleles in challenging applications, such as cell-free DNA analysis from liquid biopsies. Standard bioinformatics pipelines for data processing and variant calling are not adapted for deep-sequencing data containing UMIs, are inflexible, and require multistep workflows or dedicated computing resources.

Methods
We developed a bioinformatics pipeline using Python and an R package for data analysis and visualization. To validate our pipeline, we analyzed cell-free DNA reference material with known mutant allele frequencies (0%, 0.125%, 0.25%, and 1%) and public data sets.

Results
We developed UMIErrorCorrect, a bioinformatics pipeline for analyzing sequencing data containing UMIs. UMIErrorCorrect only requires fastq files as inputs and performs alignment, UMI clustering, error correction, and variant calling. We also provide UMIAnalyzer, a graphical user interface, for data mining, visualization, variant interpretation, and report generation. UMIAnalyzer allows the user to adjust analysis parameters and study their effect on variant calling. We demonstrated the flexibility of UMIErrorCorrect by analyzing data from 4 different targeted sequencing protocols. We also show its ability to detect different mutant allele frequencies in standardized cell-free DNA reference material. UMIErrorCorrect outperformed existing pipelines for targeted UMI sequencing data in terms of variant detection sensitivity.

Conclusions
UMIErrorCorrect and UMIAnalyzer are comprehensive and customizable bioinformatics tools that can be applied to any type of library preparation protocol and enrichment chemistry using UMIs. Access to simple, generic, and open-source bioinformatics tools will facilitate the implementation of UMI-based sequencing approaches in basic research and clinical applications.
Unusual interventional treatment of a complex calcified coronary artery lesion in a child with Kawasaki disease: a case report
Authors: Mézier Anthony , Dauphin Claire , Souteyrand Géraud , Motreff Pascal 
Published: August 2022

Abstract

Background
Kawasaki disease (KD) is a medium vessel vasculitis occurring in children, as yet of undetermined aetiology. KD can lead to severe complications such as coronary artery aneurysms, thrombosis, and sudden death. Monitoring of coronary anomalies is an important issue in the early phase of the disease, and their follow-up is based on different imaging methods. The interventional treatment of these coronary anomalies, which is often complex, is a therapeutic challenge.

Case summary
We are reporting the case of a four-year-old child who presented KD which was complicated by coronary aneurysm of the proximal left anterior descending artery and ectasia of the right coronary artery (RCA). These lesions progressively calcified and resulted at the age of 13 in chronic occlusion of the RCA. After confirmation of myocardial viability and myocardial ischaemia, a complex angioplasty guided by intracoronary imaging was performed using rotational atherectomy, a cutting balloon, and a high pressure balloon. The control coronary angiography performed 1 year later revealed two false aneurysm on the RCA at the angioplasty site, which were successfully treated with a covered stent.

Discussion
This case report describes the challenges of treating coronary artery abnormalities such as calcified coronary lesions in children with KD. The coronary intervention of these lesions remains complex and may lead to coronary rupture. We highlight the advantage of using intracoronary imaging in the management of these calcified lesions for successful revascularization, and to assess the complications of percutaneous coronary intervention.
Foreign investments and tariff protection revisited: correcting the trade balance of the Russian Empire, 1880–1913
Authors: Chuchko Marina 
Published: August 2022

Abstract
This article examines the accuracy of Russian foreign trade statistics between 1880 and 1913 and provides empirical evidence that prior to the introduction of the gold standard in 1897, Russia’s trade surplus was systematically understated. My novel trade data suggest a higher degree of protectionism with an increase of an ad valorem equivalent tariff up to 4 percentage points. Moreover, my corrections of the current account balance reduce the annual average deficit of the balance for 1885–1897 by 67 percent, supporting the idea that there was a substantial increase of foreign investments in the post-gold standard period in Russia.
A proposed checklist for climate-friendly sport and exercise programmes
Authors: Abu-Omar Karim , Messing Sven , Tcymbal Antonina , Fleuren Tobias , Richardson Diana , Whiting Stephen , Gelius Peter , Wickramasinghe Kremlin 
Published: August 2022

Abstract

Background
Fighting the climate crisis is the greatest challenge of our time and will touch all aspects of people’s lives. In this context, the United Nations (UN) have called on the sport sector to reduce its negative impacts on the environment and show ‘climate leadership’. While some efforts have already been made with regards to mega sport events, there is still a dearth of approaches on limiting the climate impact of recreational sport and exercise programmes.

Methods
Based on the UN-Framework ‘Sports for Climate Action’, literature reviews and additional desk research, a checklist to support local level stakeholders in providing climate-friendly sport and exercise programmes was developed.

Results
The proposed checklist consists of five dimensions that need to be considered when designing and offering a climate-friendly sport and exercise programme: (i) active transport to exercise programmes, (ii) the carbon footprint of different types of exercises, (iii) low carbon sport clothing and equipment, (iv) instructors as champions for climate action and (v) advertising and communication. These five dimensions result in a 16-item checklist that supports the planning, advertising, implementation and evaluation of climate-friendly sport and exercise programmes.

Conclusions
The proposed checklist intends to facilitate the development of climate-friendly sport and exercise programmes. However, additional work is needed to test the implementation of the checklist at the local level. While the sport sector can make its own contributions to reduce its climate impact, intersectoral action is needed to improve infrastructure for active transport and to build sustainable sport facilities.
S02 Physical activity surveillance across the life-course: from data to policy
Authors: Whiting Stephen , Williams Julianne , Mendes Romeu , Milanovic Sanja Music , Kovacs Viktoria A , Wickramasinghe Kremlin 
Published: August 2022

Abstract
As a major risk factor for non-communicable diseases (NCDs), physical inactivity is a prominent challenge for public health. The purpose of this symposium is to present an overview of physical inactivity prevalence in Europe using data collected through international surveillance initiatives, while highlighting successes and discussing future challenges for utilising data to promote physical activity across the life course.
The World Health Organization (WHO) is involved in several physical activity surveillance systems on which discussions during this symposium will be based:
1. The WHO European Childhood Obesity Surveillance Initiative (COSI) is the largest survey of its kind in the world. An overview of results from the most recent round of COSI will be presented focusing on prevalence estimates for physical activity, screen time and sleep. Variations between countries of the socioeconomic determinants of physical inactivity, as well as the impact of the COVID-19 pandemic, will demonstrate the ongoing need for quality data to guide targeted policy actions in support of vulnerable groups throughout the life course. 2. The WHO’s STEPwise approach to surveillance (STEPS) survey provides important national level prevalence data on the behavioural and metabolic risk factors for NCDs. For many countries, the STEPS survey has provided the first estimates of physical inactivity and sedentary behaviour in the population and has been essential in raising awareness of the need for national policy actions to increase population levels of physical activity. 3. The European Commission, with the support of the WHO Regional Office for Europe, has established the European Union Physical Activity Focal Points Network to monitor implementation of the 23 indicators of the Health-Enhancing Physical Activity (HEPA) monitoring framework on physical activity policy development and implementation. 4. Within the European Union Physical Activity Focal Points Network, and during the COVID-19 pandemic, some countries established a survey on physical activity and screen time in children and adolescents.
S03-3 Staying active together in sports - the importance of and how to promote the emotional domain of Physical literacy
Authors: Nielsen Glen , Bentsen Peter , Elsborg Peter 
Published: August 2022

Abstract

Background
Club-based sports participation through adolescent years is associated with improved health and wellbeing and is therefore considered and important part of health promotion in Scandinavian welfare states. Participation rates are very high among children whereas dropout rates increase during the adolescent years. Many studies have shown how intentions to continue in sport is dependent on autonomous motivation, which is dependent on basic psychological needs satisfaction and hence needs support in the social environment of the team. It has also been shown that the coach has central influence on social environment of the team. The SATS study is a prospective study on the influence of coach-created social climate on young club-sport participants’ psychological needs satisfaction, motivation and continuation the following season.

Methods
Participants were 6400 adolescent members of leisure time club-organized Basketball, Handball, Football and Gymnastics in Denmark. In the baseline-season coach-created climate was measured with the EDMCQ-C, Basic Psychological needs satisfaction and frustration was measured with PNSS-S and behavioral regulation (motivation) was measured with BRSQ. The participants’ continuation or dropout the next season was measured with a short SMS based questionnaire the next season.

Results
Task oriented, social supportive and autonomy supportive coach behaviors were associated with higher basic needs satisfaction, autonomous motivation and continuation the next season across sports, ages, levels and genders. Ego-oriented and controlling coaching behaviors were associated with needs frustration, controlled motivation and dropout.

Conclusions
Empowering Coaching behavior is important for young sports participants’ wellbeing and continuation in sport.
S04 Sports Club for Health (SCforH) approach: evidence on importance and examples of implementation activities
Authors: Pedišić Željko , Titze Sylvia 
Published: August 2022

Abstract
There are more than 60 million sports club members in the EU, which makes sports clubs an organizational settings with a huge potential for health promotion. The Sports Club for Health (SCforH) initiative started in 2008, to assist sports clubs in promoting health-enhancing physical activity. In support of this endeavour, SCforH guidelines were issued in 2011 and updated in 2017. The SCforH initiative has been supported by three large European Union grants and included partner organisations from 18 countries. In 2013, the Council of the European Union proposed the national implementation of SCforH guidelines as one of the 23 indicators for evaluation of HEPA levels and policies in the European Union member states. Recently, the European Commission recognised the SCforH initiative as a ‘success story' and an example of good practice. The aim of this symposium is to summarize recent evidence relevant to the promotion of health-enhancing physical activity through sports clubs in the EU and to discuss about future directions and challenges for EU public health efforts in this area. The symposium will include five 10-minute presentations on: [i] the findings of an updated systematic review on health benefits of different sport disciplines; [ii] Hungarian implementation of a SCforH intervention; [iii] the effectiveness of a coordinated action between the healthcare sector and local sports clubs to promote physical activity; [iv]; tracking participants in Jackpot.fit program?an Austrian sport promotion initiative; and [v] the development of a SCforH online learning tool. The symposium program will also include: Introduction by Chair (5 minutes), 25 minutes of Q&A, and conclusion by Discussant (10 minutes).
Discussant: Prof Nanette Mutrie, Moray House School of Education and Sport, ISPEHS research cluster, University of Edinburgh, United Kingdom - nanette.mutrie@ed.ac.uk
S04-5 Development of the Sports Club for Health (SCforH) online learning tool
Authors: Jurakic Danijel , Matolic Tena , Pedisic Zeljko 
Published: August 2022

Abstract

Background
In 2019, the European Commission provided funding of nearly 400 thousand Euro for the third round of the Sports Club for Health (SCforH) project. The objective of this project is to increase participation in sport and HEPA in the European Union by encouraging sports clubs and associations to implement SCforH principles in their activities. To achieve the objective of the project, in this study we aimed to develop a SCforH online learning tool.

Methods
Through a comprehensive literature search and consultations with the stakeholders in the area of sport, we created a list of examples of good practice in implementing SCforH initiatives and other related HEPA promotion practices in the sports context. The list was used to inform the development of the SCforH online learning tool. The SCforH online learning tool was developed through a consultation process including 15 experts in the area of sport and health.

Results
The SCforH online learning tool includes: a participation consent form; a module for setting learning objectives, textual, pictorial, and video learning materials; interactive learning exercises; in-course quizzes and self-assessment modules; a link to the database of SCforH initiatives and other related practices in the European Union; links to other available online materials for those who want to know more; a module for the assessment of acquired knowledge; a participant feedback module; an optional survey including questions relevant for the evaluation of SCforH activities.

Conclusions
The SCforH online learning tool will enable the realisation of other aims of the current SCforH project, in particular, raising the awareness of the SCforH guidelines among: European sports clubs; sport associations; HEPA promoters; policymakers; and students of physical education, sport science, and public health.
S05 Active ageing from theory to practice: success stories from Belgium, Finland, Germany and the Netherlands
Authors: Borodulin Katja , Boen Filip , Preller Liesbeth , Starck Heli , Mueller-Steck Ute , van Uffelen Jannique 
Published: August 2022

Abstract

Introduction
Research increases our understanding on the efficacy of exercise and physical activity on older adults' health and well-being. However, the scientific output is relevant in experimental or clinical settings only and cannot be easily implemented in real-life setting. Consequently, the public health impact of the research output fails to be scaled-up for audiences and target groups at large. We therefore need more evidence on theory-to-practice approaches, in which physical activity interventions pay more attention to practical implementation.

Aim
The aim of this symposium is to describe successful examples on active ageing from research-to-practice. Examples are from 4 countries where different approaches are being used to improve adoption, implementation and maintenance physical activity among older people. Relevant scientific frameworks like RE-AIM and implementation science are utilized.
S05-2 Tenth anniversary of ‘moment! - motor learning and mental training for people with a beginning dementia'
Authors: Mueller-Steck Ute , Zacharides K Karen 
Published: August 2022

Abstract
Currently 1.7 million people in Germany are living with dementia and two out of three such persons are nursed at home. Considering this challenging situation, we started in 2010 the project “moment! - motor learning and mental training for people with an incipient dementia”. Our aim was to develop a special qualification for people who are interested in conducting physical exercise groups for persons suffering from dementia. It has been scientifically proven that physical exercises show a positive impact on people with dementia: Training in groups is motivating and influences the emotional state in a positive way. Furthermore, social contacts are supported and maintained and prevent from social isolation. Therefore, a higher life fulfillment can be increased temporarily, and self-confidence is growing as well. Socio political goals are the integration of affected persons into existing social structures like sports associations, the raise of public awareness for dementia, and to strengthen the possibilities of integrating people suffering from dementia into regular social life. All scientific analysis proves that motion has a positive impact on the process of dementia and is a successful prophylactic and therapeutic support of the common medical treatment.
The project includes a qualification for multipliers such as care assistants, trainers in local sport associations, nursing staff and volunteers in care organisations in order to support people suffering from dementia. This training consists of five days (and a total of 40 learning units) and is offered as an attendance seminar. During the course the participants will be trained in basic knowledge and clinical pictures of dementia, above all they receive many ideas for practical motor and mental exercises. Additionally, all participants receive a workbook and a music CD for the rhythm and dance lessons. Within the last 10 years we have qualified about 440 people in 27 trainings. Many “moment!” training-groups have been built - most of them in nursing homes and a few in cooperation with a local sports club.