bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographics, pattern of practice and clinical outcomes in rectal squamous cell carcinoma
Authors: Id Said Badr , Buchan David , Liu Zijin , Kim John , Hosni Ali , Brierley James D. , Chadi Sami , Grant Robert C. , Kalimuthu Sangeetha , Liu Zhihui Amy , Lukovic Jelena 
Published: November 2022

AbstractAimThe aim of this study was to describe the baseline clinical features, treatment patterns and outcomes in rectal squamous cell carcinoma (SCC).MethodThis is a retrospective study of patients with rectal SCC treated at the Princess Margaret Cancer Centre (Toronto, Canada) between 1 January 1995 and 31 December 2020. Clinical factors associated with locoregional failure (LRF), distant metastases (DM), disease‐free survival (DFS) and overall survival (OS), such as age, sex, HIV status, T‐category, nodal status, grade and primary treatment, were investigated with univariate analysis (UVA).ResultsTwenty nine patients with rectal SCC were analysed with a median follow‐up of 7.4 years (range 0.3–20.4 years). The median age at diagnosis was 52 years, with the majority presenting with clinical T3 disease or higher (n = 21, 72%) and positive regional lymph nodes (n = 16, 55%), while more than quarter of patients (28%) had metastatic disease. Definitive chemoradiation was the treatment modality of choice in more than half of all cases (n = 17, 59%) with a response rate of 100%. The 10‐year cumulative incidence of LRF and DM was, respectively, 12% (95% CI 1.8%–32.9%) and 31% (95% CI: 12.0%–52.6%). The 5‐ and 10‐year OS was 82% (95% CI 66.1%–100%). UVA revealed a trend towards an association of male gender (hazard ratio = 4.65, 95% CI 0.9%–24.1; p = 0.067) and primary surgical treatment (hazard ratio = 0.76, 95% CI 0.09–6.34; p = 0.061) with DFS.ConclusionDefinitive chemoradiation is an effective and preferred treatment for rectal SCC allowing for sphincter preservation with complete clinical response observed in all patients.
Increasing audiovisual speech integration in autism through enhanced attention to mouth
Authors: Feng Shuyuan , Wang Qiandong , Hu Yixiao , Lu Haoyang , Li Tianbi , Song Ci , Fang Jing , Chen Lihan , Yi Li 
Published: November 2022

AbstractAutistic children (AC) show less audiovisual speech integration in the McGurk task, which correlates with their reduced mouth‐looking time. The present study examined whether AC's less audiovisual speech integration in the McGurk task could be increased by increasing their mouth‐looking time. We recruited 4‐ to 8‐year‐old AC and nonautistic children (NAC). In two experiments, we manipulated children's mouth‐looking time, measured their audiovisual speech integration by employing the McGurk effect paradigm, and tracked their eye movements. In Experiment 1, we blurred the eyes in McGurk stimuli and compared children's performances in blurred‐eyes and clear‐eyes conditions. In Experiment 2, we cued children's attention to either the mouth or eyes of McGurk stimuli or asked them to view the McGurk stimuli freely. We found that both blurring the speaker's eyes and cuing to the speaker's mouth increased mouth‐looking time and increased audiovisual speech integration in the McGurk task in AC. In addition, we found that blurring the speaker's eyes and cuing to the speaker's mouth also increased mouth‐looking time in NAC, but neither blurring the speaker's eyes nor cuing to the speaker's mouth increased their audiovisual speech integration in the McGurk task. Our findings suggest that audiovisual speech integration in the McGurk task in AC could be increased by increasing their attention to the mouth. Our findings contribute to a deeper understanding of relations between face attention and audiovisual speech integration, and provide insights for the development of professional supports to increase audiovisual speech integration in AC.Highlights
The present study examined whether audiovisual speech integration in the McGurk task in AC could be increased by increasing their attention to the speaker's mouth.
Blurring the speaker's eyes increased mouth‐looking time and audiovisual speech integration in the McGurk task in AC.
Cuing to the speaker's mouth also increased mouth‐looking time and audiovisual speech integration in the McGurk task in AC.
Audiovisual speech integration in the McGurk task in AC could be increased by increasing their attention to the speaker's mouth.
Long‐term effects of transcranial direct current stimulation in the treatment of autism spectrum disorder: A randomized controlled trial
Authors: Auvichayapat Paradee , Intayot Krittiya , Udomchat Chavisa , Suphakunpinyo Chanyut , Patjanasoontorn Niramol , Keeratitanont Keattichai , Tunkamnerdthai Orathai , Jensen Mark P. , Humbert Andrew T. , Auvichayapat Narong 
Published: November 2022

AbstractAimTo compare the efficacy of 0, 5, and 20 sessions of transcranial direct current stimulation (tDCS) for reducing symptoms of autism spectrum disorder (ASD).MethodThirty‐six male children with ASD (mean age 2 years 3 months, SD 4 months, age range 1 years 6 months–2 years 11 months) were balanced and stratified by age, sex, and baseline severity of ASD, to: (1) a control group that received 20 sessions of sham tDCS; (2) a 5‐session tDCS group (5‐tDCS) that received 5 sessions of active tDCS followed by 15 sessions of sham tDCS; and (3) a 20‐session tDCS group (20‐tDCS) that received 20 sessions of active tDCS. All groups participated in the special school activity of Khon Kaen Special Education Center, Thailand. The primary outcome was autism severity as measured by the Childhood Autism Severity Scale.ResultsThe 5‐tDCS and 20‐tDCS groups evidenced greater reductions in autism severity than the control group at days 5 and 14, and months 6 and 12. There were no significant differences in the outcome between the 5‐ and 20‐tDCS groups at any time point. Within‐group analysis showed clinically meaningful improvements starting at month 6 for the participants in the control group, and clinically meaningful improvements starting on day 5 in both active tDCS groups, all of which were maintained to month 12.InterpretationThe 5‐ and 20‐session tDCS seems to reduce autism severity faster than sham tDCS. These effects maintained at least for 1 year.What this paper adds

Twenty sessions of transcranial direct current stimulation (tDCS) were not superior to five sessions.
Sham tDCS with a special school activity can reduce autism severity starting at 6 months after treatment.
The benefits observed for 5 and 20 sessions of tDCS last for at least 12 months.
Silk‐assisted hatching of the Japanese bagworm moth Eumeta variegata (Lepidoptera: Psychidae)
Authors: Yamada Nobuto , Yoshioka Taiyo , Sagisaka Aki , Kameda Tsunenori , Ichiki Ryoko T. 
Published: November 2022

AbstractBagworms constantly carry a portable bag with their prolegs inside, even when walking. Therefore, bagworms have a unique walking style. Bagworms construct footholds with silk and walk using only their thoracic legs. Bagworms build their bag immediately after hatching and carry them for the rest of their lives. Therefore, the only period when they move without a bag is immediately after hatching, when they move away from the hatched egg. We assessed their movement behavior in the period immediately after hatching when all legs were available, including prolegs. Our observations revealed that hatching Eumeta variegata (Japan's largest bagworm species) spun foothold silk threads even as they left the egg. From the moment the head broke out of the egg, larvae began spinning foothold silk threads. To do this, larvae twisted their anterior regions approximately 90° immediately before hatching. This finding indicates that larvae prepare to spin foothold silk threads during embryonic development.
Reduced expression of CXCL16/CXCR6 is involved in the pathogenesis of hidradenitis suppurativa
Authors: Wang Zhongshuai , Zhao Huijuan , Zhai Wanying , Zhang Xiaofeng , Li Li , Yuan Chen , Li Yi , Li Yangqun , Yan Yan , Wang Baoxi 
Published: November 2022

AbstractMutations in the γ‐secretase complex have been well‐described in familial hidradenitis suppurativa (HS). No gene mutations have been identified in sporadic HS, which comprises 60%–70% of all HS cases. Obesity and smoking are risk factors for HS and are closely related to DNA methylation, an essential epigenetic phenomenon. Hence, we hypothesized that epigenetic modifications might be involved in sporadic HS. To investigate genes with aberrant methylation in sporadic HS cases and assess their expression in skin lesions and blood from patients with HS. Skin lesion samples and corresponding normal skin were obtained from three patients with HS and subjected to whole‐genome DNA methylation sequencing. Blood samples were collected from 20 patients with HS and 20 healthy controls (HCs). The HS mouse model was established by applying tamoxifen to NcstnΔKC mice. Target gene expression was analysed by immunohistochemistry, immunofluorescence, western blotting, enzyme‐linked immunosorbent assay (ELISA) and semiquantitative real‐time polymerase chain reaction (RT‐qPCR). Among 10 807 differentially methylated genes, we filtered 2101 genes with hypermethylated promoter regions, and following bioinformatics analyses, we focused on CXC chemokine ligand 16 (CXCL16). Subsequent functional experiments confirmed the downregulation of CXCL16 and its receptor, CXC chemokine receptor (CXCR) 6, in skin tissue from HS patients and NcstnΔKC mice. Serum CXCL16 concentrations were also significantly decreased in patients with HS. Our data revealed the downregulation of CXCL16 and CXCR6 in HS.
Effects of elevated water temperature on cutthroat trout angler catch rates and catch‐and‐release mortality in Idaho streams
Authors: Meyer Kevin A. , McCormick Joshua L. , Kozfkay Joseph R. , Dillon Jeff C. 
Published: November 2022

AbstractThe concern is growing that angling may need to cease at elevated summer water temperatures to protect salmonid populations. Cutthroat Trout Oncorhynchus clarkii in streams were caught, marked and released using artificial dry flies at temperatures from 13.5 to 25.7°C to evaluate whether subsequent recapture with backpack electrofishing (an index of relative survival) was reduced when the water temperature was elevated at the time of landing, and to evaluate the effect of water temperature on angler catch rates. The electrofishing recapture rate of marked fish (i.e. relative survival) declined as water temperature increased, from 0.58 for fish landed at <21°C to 0.35 at 21–23°C and 0.17 at >23°C. However, angler catch declined similarly as water temperature increased, from 5.2 fish/h at <21°C to 4.1 fish/h at 21–23°C and 1.2 fish/h at >23°C. After accounting for both declines, fish mortality/angler might be higher at cooler water temperatures than at warmer temperatures. Therefore, inhibiting fishing at elevated water temperatures may not benefit trout populations any more than at cooler temperatures.
Youth engagement in mental health research: A systematic review
Authors: McCabe Erin , Amarbayan Mungunzul (Megan) , Rabi Sarah , Mendoza Justino , Naqvi Syeda Farwa , Thapa Bajgain Kalpana , Zwicker Jennifer D. , Santana Maria 
Published: November 2022

AbstractIntroductionPatient engagement in youth mental health research has the potential to inform research on the interventions, services and policies that will benefit youth. At present, there is little evidence to guide mental health researchers on youth engagement. This systematic review aims to describe the impacts of youth engagement on mental health research and to summarize youth engagement in mental health research.MethodsWe searched the following databases: MEDLINE, EMBASE and PsycINFO, using a combination of subject headings, keywords and synonyms for the concepts ‘patient engagement’, ‘youth’ and ‘mental health’. Articles that described engaging youth in mental health research were included. Two reviewers performed the study selection. Study characteristics, research activities performed by youth, impacts of youth engagement, challenges, and facilitators to engagement and recommendations for youth engagement described by authors were extracted. Quality appraisal involved determining the level of engagement of youth and the stage(s) of research where youth were involved.ResultsThe database search returned 2836 citations, 151 full‐text articles were screened and 16 articles, representing 14 studies, were selected for inclusion. Youth were involved at nearly all stages of the research cycle, in either advisory or co‐production roles. Youth engagement impacts included enhancing relevant research findings, data collection and analysis and dissemination to academic and stakeholder audiences. Both youth and academic researchers reported personal development across many domains. One negative impact reported was the increase in funding and resources needed for engagement. We produced a list of 35 recommendations under the headings of training, youth researcher composition, strategy, expectations, relationships, meeting approaches and engagement conditions.ConclusionsThis study provides an understanding of the impacts and recommendations of youth engagement in mental health research. The findings from this study may encourage researchers to engage youth in their mental health research and support youth engagement in funding applications.Patient and Public ContributionWe consulted three youths with experience being engaged in mental health research about the review findings and the discussion. One youth designed a visual representation of the results and provided feedback on the manuscript. All youth's input informed the way the findings were presented and the focus of the discussion.
Sedimentology and biostratigraphy of the upper Triassic carbonates from the Shiriya cape, North Kitakami Belt, Japan
Authors: Peyrotty Giovan , Fucelli Andrea , Peybernes Camille , Onoue Tetsuji , Ueda Hayato , Martini Rossana 
Published: November 2022

AbstractRelics of the Panthalassa Ocean occur today in accretionary complexes and terranes on the entire Circum‐Pacific region. Among them, remains of shallow‐water carbonate systems provide valuable information about the ecology and environmental conditions that prevailed in this immense ocean. In this regard, the Shiriya Cape of the North Kitakami Belt (Aomori Prefecture, Honshu Island, Japan) is an essential place to study. Characterized by the presence of numerous limestone deposits embedded in typical accretionary mélange, including pluri‐kilometric massive slabs and metric bedded deposits, the cape is indeed a key vestige of carbonate deposition in the Panthalassa. All the limestone outcrop form the Shiriya Cape were sampled and studied in detail for the first time. Despite a general poor preservation, macroscopic sedimentary features such as burrows and large megalodontids patches as well as four microfacies were identified and are presented in detail in this work. On the basis of foraminifers and conodonts biostratigraphy, the age of the limestone deposits is defined as Norian. Similarities with analogous and synchronous systems from Panthalassan and Tethyan realms are extensively discussed. The closest analog to the Shiriya limestone appears to be the Panthalassan Dalnegorsk limestone (Russian Far East), both regarding microfacies and depositional setting. Sedimentary successions similar to Lofer‐cycles, well known in Tethyan synchronous systems, were also discovered in the Shiriya Cape. Along with the large limestone slabs, countless limestone‐bearing conglomerates also crop out on the Shiriya Cape. Their study and comparison with similar deposits in Japan highlighted their importance in the understanding of the dismantling of mid‐oceanic carbonates. The observations and comparison with well‐known carbonate systems permitted to establish a hypothetical depositional model of the Shiriya limestone corresponding to a Norian isolated carbonate system developed on an immerged volcanic seamount.
A preemptive goal programming for multi‐objective cooperative games: an application to multi‐objective linear production
Authors: Nan Jiangxia , Wei Lixiao , Li Dengfeng , Zhang Maojun 
Published: November 2022

AbstractThe aim of this study is to investigate the fair allocation of multi‐objective cooperative games (MOCGs) using a preemptive goal programming (PGP). First, this research establishes the PGP model, where the priority factors of PGP describe the importance degrees of different objectives in MOCGs, the positive and negative deviations of PGP present the relation between the overall payoff and the worth of a coalition, and the weighting factors of negative deviations of PGP express the coalition weights of MOCGs. Second, we investigate the relationships between the solutions of the PGP model and the cores of MOCGs, including the preference core, preference ‐core, and dominance core. Our analysis shows that the optimal solution of PGP belongs to the preference core, and the satisfactory solution of PGP satisfying certain conditions belongs to the dominance core or preference ‐core. Finally, we demonstrate the practical and managerial relevance of our results by applying our findings to a multi‐objective linear production to produce certain kinds of goods using different resources for multi‐firms with varying objectives and illustrate them numerically.
Enhanced adsorption behavior of U(VI) using PZSC/ZnO ceramic composite derived from polyphosphazene
Authors: Bao Yunyun , Liu Yan , Wang Changfu , Wang Yun , Yuan Dingzhong , Zhu Zuqing , Xu Jianda , Liu Jinbiao 
Published: November 2022

AbstractIn this study, a new type of ceramic composite (PZSC/ZnO) was successfully synthesized using N, P, and S co‐doped carbon microspheres derived from polyphosphazene with zinc oxide. The morphology and structure were characterized by Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, scanning electron microscopy, energy‐dispersive spectroscopy, Raman, X‐ray diffraction, BET, and thermogravimetric. Batch experiments were used to explore the adsorption performance under different pH values, initial concentrations, contact times, and temperatures. The results showed that the maximum adsorption capacity of the PZSC/ZnO ceramic composite for uranium was 470.5 mg/g (pH = 5.5, t = 40 min, and T = 25°C). The adsorption process followed the nonlinear Langmuir model and the pseudo‐second‐order kinetic model, demonstrating that the monolayered combination of U(VI) with the PZSC/ZnO ceramic composite and the adsorption mechanism was chemical adsorption. Thermodynamic data revealed that the adsorption was a spontaneous endothermic process. Furthermore, P and N may be involved in the adsorption of uranyl ions through binding to the O atoms from ZnO. The main forces between U(VI) and the PZSC/ZnO ceramic composite were attributed to ZnO and heteroatoms doped in the material.
A conflicted tribe under pressure: A qualitative study of negative workplace behaviour in nursing
Authors: Hawkins Natasha , Jeong Sarah Yeun‐Sim , Smith Tony , Sim Jenny 
Published: November 2022

AbstractAimThis study explored workplace interactions of Australian nurses in regional acute care hospitals through an examination of nurses' experiences and perceptions of workplace behaviour.DesignThis research is informed by Social Worlds Theory and is the qualitative component of an overarching mixed methods sequential explanatory study.MethodsBetween January and March 2019, data were collected from 13 nursing informants from different occupational levels and roles, who engaged in semi‐structured, in‐depth, face‐to‐face interviews. Data analysis was guided by Straussian grounded theory to identify the core category and subcategories.ResultsTheoretical saturation occurred after 13 interviews. The core category identified is A conflicted tribe under pressure, which is comprised of five interrelated subcategories: Belonging to the tribe; ‘It's a living hell’; Zero tolerance—‘it's a joke’; Conflicted priorities; Shifting the cultural norm.ConclusionThis study provides valuable insight into the nursing social world and the organizational constraints in which nurses work. Although the inclination for an individual to exhibit negative behaviours cannot be dismissed, this behaviour can either be facilitated or impeded by organizational influences.ImpactBy considering the nurses' experiences of negative workplace behaviour and identifying the symptoms of a struggling system, nurse leaders can work to find and implement strategies to mitigate negative behaviour and create respectful workplace behaviours.Patient or Public ContributionThis study involved registered nurse participants and there was no patient or public contribution.Clinical Trial RegistrationStudy registration Australian New Zealand Clinical Trials Registry (Registration No. ACTRN12618002007213; December 14, 2018).
People with intellectual disabilities and harmful sexual behaviour: Professionals' views on the barriers to prevent harm
Authors: Svae Gøril Brevik , Hassel Bjørnar , Søndenaa Erik 
Published: November 2022

AbstractBackgroundPeople with intellectual disabilities can be exposed to sexual abuse and they can display harmful sexual behaviour. This study aimed to identify barriers to preventing harmful sexual behaviour in people with intellectual disabilities within the support sector and the justice system.MethodWe conducted focus group interviews with 20 participants from hospital‐based habilitation centres, community residences, schools and the criminal justice system.ResultsThe interviews identified a lack of education and guidelines for stakeholders or carers on regulating the sexual behaviour of people with intellectual disabilities. The criminal justice system faces challenges related to prioritising, understanding and communicating. People with intellectual disabilities may lack an understanding of the concepts of sexual consent and acceptable sexual behaviour.ConclusionThere is a need to improve knowledge about intellectual disability and how to prevent harmful sexual behaviour for professional caregivers in the support sector and the criminal justice system.
CUL4B increases platinum‐based drug resistance in colorectal cancer through EMT: A study in its mechanism
Authors: Luo Jian‐Wu , Wang Chun‐Ming , Su Jian‐Wei , Yi Ting‐Zhuang , Tang Shao‐Hui 
Published: November 2022

AbstractPlatinum‐based chemotherapy drugs play a very important role in the treatment of patients with advanced colorectal cancer, but the drug resistance of platinum‐based chemotherapy drugs is an important topic that puzzles us. If we can find mechanisms of resistance, it will be revolutionary for us. We analysed the differential genes, core genes and their enrichment pathways in platinum‐resistant and non‐resistant patients through a public database. Platinum‐resistant cell lines were cultured in vitro for in vitro colony and Transwell analysis. Tumorigenesis analysis of nude mice in vivo. Verify the function of core genes. Through differential gene and enrichment analysis, we found that CUL4B was the main factor affecting platinum drug resistance and EMT. Our hypothesis was further verified by in vitro drug‐resistant and wild‐type cell lines and in vivo tumorigenesis analysis of nude mice. CUL4B leads to platinum drug resistance in colorectal cancer by affecting tumour EMT.