bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D PED BURN app: A precise and easy‐to‐use pediatric 3D burn surface area calculation tool
Authors: Meevassana Jiraroch , Sumonsriwarankun Piyamit , Suwajo Poonpissamai , Nilprapha Kasama , Promniyom Pasu , Iamphongsai Seree , Pungrasmi Pornthep , Jindarak Sirachai , Kangkorn Tanasit , Angspatt Apichai 
Published: June 2022

AbstractBackground and aimsCalculating the precise total burn surface area is crucial when treating burn patients, particularly children. The Lund and Browder chart and Rule of Nines, 2‐dimensional diagrams that are widely used, are subject to high interrater variance, and they can severely overestimate the burn area. Previously, the adult 3‐dimensional burn area calculation mobile application was developed. Aiming to improve accuracy, a 3‐dimensional pediatric burn surface area calculation mobile application (“3D PED BURN”) was developed to overcome the limitations of the conventional methods.MethodFifteen 3‐dimensional pediatric burn surface area models based on detailed anthropometric measurements collected from 85 patients were developed and categorized into four age groups: <1 year; 1–4 years; 5–9 years, and 10–15 years. According to their weight and height, the models in each group were fractionated into large, medium, and small body sizes.ResultA precise and easy‐to‐use application was developed based on these data. This application is a promising and more accurate calculation tool for burn surface area in pediatric patients. Its low inter‐rater variance makes it reliable for use by various healthcare personnel.ConclusionThe 3D PED BURN app is a pediatric 3D burn surface area calculation tool that is both accurate and simple to use.
Safety and efficacy of coronavirus disease‐19 vaccines in chronic kidney disease patients under maintenance hemodialysis: A systematic review
Authors: Mehta Neha , Shah Sangam , Paudel Kiran , Chamlagain Rajan , Chhetri Santosh 
Published: June 2022

AbstractBackground and aimsPatients on maintenance dialysis are a high‐risk, immune‐compromised population with 15%–25% coronavirus disease (COVID‐19) mortality rate that has been underrepresented in COVID‐19 vaccination clinical trials. The aim of study was to review of those studies to determine the safety and efficacy of the COVID‐19 vaccination in chronic kidney disease (CKD) patients receiving maintenance hemodialysis systematically.MethodsThe effectiveness was assessed by looking at the humoral and cellular responses. The humoral response is defined as de novo IgG‐ or IgA‐anti‐SpikeS1 antibody positivity. The establishment of de novo T‐cell immunity after immunization was used to measure cellular response. Adverse results were also reported of the included studies to analyze the safety of COVID‐19 vaccines. Eight previous works were included in our study.ResultsTwo doses of COVID‐19 vaccines were shown to be effective with seroconversion rate of humoral response ranging from 81% to 97% among eight studies. The T‐cell response was shown 67% and 100% in two studies. COVID‐19 vaccines did not have notable adverse events and hence can be considered safe.ConclusionAlthough a single dosage has not shown to improve humoral immune response in most hemodialysis trials, a double dose has been reported to improve seroconversion rate and humoral immune response. Further research are required to observe if hemodialysis patients generate effective T‐cell responses.
Microsurgical varicocelectomy for intratesticular varicocele with a history of orchiopexy for undescended testis
Authors: Takeshima Teppei , Usui Kimitsugu , Kuroda Shinnosuke , Kawahara Takashi , Komeya Mitsuru , Teranishi Jun‐ichi , Uemura Hiroji , Yumura Yasushi 
Published: June 2022

IntroductionWe report a case series of six patients with a chief complaint of infertility who underwent microsurgical varicocelectomy for intratesticular varicocele (ITV) after undergoing orchiopexy for undescended testis in their childhood.Case presentationThe patients' median age was 34 years. The median age at which orchiopexy was performed was 4.5 years. All the cases of ITV were accompanied by extratesticular varicocele (ETV). All the patients underwent a microsurgical subinguinal varicocelectomy. At 3 months after operation, the ITV and ETV had disappeared in all the cases. Sperm density and motility increased in five and four patients, respectively.ConclusionITV occurs at a relatively high frequency after orchiopexy for undescended testis. Disorder of the valvular function of the testicular vein in peeling the testicular vessels was thought to be a primary cause and is often found on the left side. Doppler ultrasonography of the testis is considered important for diagnosis.
Theoretical studies on excited‐state properties and luminescence mechanism of a Carbene–Metal–Amide Au(I) complex with thermally activated delayed fluorescence
Authors: Sun Xin‐Wei , Peng Ling‐Ya , Gao Yuan‐Jun , Ye Jin‐Ting , Cui Ganglong 
Published: June 2022

AbstractTwo‐coordinate Carbene−Metal−Amide (CMA) complexes with thermally activated delayed fluorescence (TADF) have attracted much attention owing to their excellent luminescence properties and potential applications in organic light‐emitting devices. However, the luminescence mechanism remains unclear. Herein, we took one CMA Au(I) complex as an example and investigate its relevant photophysics using both density functional theory (DFT) and time‐dependent DFT methods with a polarizable continuum model. The calculated absorption and emission spectra agree with the experimental data and the S1 and T1 states show mixed ligand to ligand charge transfer (CT) and ligand to metal CT characters. Small spatial overlap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) minimizes the energy difference between the S1 and T1 states (ΔEST). Properly large spin‐orbit coupling promotes the reverse intersystem crossing (rISC) process. At 300 K, the rISC process is much more efficient than the T1 phosphorescent emission, which leads to the TADF emission.
CB‐103: A novel CSL‐NICD inhibitor for the treatment of NOTCH‐driven T‐cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T‐ALL
Authors: Medinger Michael , Junker Till , Heim Dominik , Tzankov Alexandar , Jermann Philip M. , Bobadilla Maria , Vigolo Michele , Lehal Rajwinder , Vogl Florian D. , Bauer Michael , Passweg Jakob 
Published: June 2022

AbstractRelapsed T cell acute lymphoblastic leukaemia (T‐ALL) has a very poor prognosis. A 24‐year‐old patient with relapsed high‐risk T‐ALL (PTEN gene deletion; NOTCH1 mutation), was treated with the NOTCH inhibitor CB‐103. Within 1 week of starting CB‐103, the bone marrow was free of T‐ALL blast infiltration (MRD+) and successfully underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Sequential samples of ctDNA to monitor the disease after allo‐HSCT showed a decrease of circulating Notch1 and PTEN alterations. This is the first T‐ALL patient treated with CB‐103. The observed clinical response encourages further exploration of CB‐103 in ALL.
COVID‐19 pandemic in Southern Brazil: Hospitalizations, intensive care unit admissions, lethality rates, and length of stay between March 2020 and April 2022
Authors: Wolf Jonas Michel , Petek Helena , Maccari Juçara G. , Nasi Luiz Antonio 
Published: June 2022

AbstractCoronavirus disease 2019 (COVID‐19) pandemic spread rapidly with more than 515 million cases and 6.2 million deaths. Epidemiological factors are important for understanding the state of the pandemic. This study aims to evaluate the hospitalizations, intensive care unit (ICU) admissions, and lethality from March 2020 to April 2022. Data were collected from a hospital in Porto Alegre city, southern Brazil. The Mann–Whitney, analysis of variance, and Kruskal–Wallis tests were used to compare quantitative variables. Categorical variables were compared by Pearson's χ2 test. p values <0.05 for all tests were considered significant. Were observed 3784 hospitalizations. Males were 51.4% and the age was 60.4± 20.3. Intensive care unit (ICU) patients were 31.2%, the median length of stay (LOS) was 9.0 and lethality was 13.3%. ICU lethality was 34.5% versus 4.6% in other inpatients (p < 0.01). The LOS of ICU patients was 22.0 versus 7.0 in other inpatients (p < 0.01). The first peak (July–Novemebr 2020) showed ICU occupancy of 79.1%. The second peak (December 2020–June 2021) with 91.6% occupancy. The third peak January–March 2022 with 81.0% occupancy (p < 0.01). Lethality rates were 10.3% in 2020, 14.9% in 2021 and 15.4% in 2022 (p < 0.01). In conclusion, the ICU occupancy rate was higher in 2021 and the lethality rates of ICU patients were high during pandemic years (10.3% in 2020, 14.9% in 2021, and 15.2% in 2022). The lethality of these patients ranged from 25.0% in March to 21.8% in December 2020, from 20.9% in January 22.2% in Decemebr 2021, and 35.7% in January 2022 to 21.4% in April 2022. These data demonstrate that COVID‐19 is a critical illness, even in a private hospital setting.
The Sociomateriality of the Creative Process: Script Roles in Film Production
Authors: Anjo José Edemir da Silva , Tureta César 
Published: June 2022

ABSTRACTThe article aims to identify and analyze the roles played by the script in the creative process of independent short film production. The theoretical framework is based on distributed creativity and sociomateriality. These approaches are complementary and helped us discuss how the script can shape the creativity of the subjects involved in the film production. We have followed the daily teamwork during the film production through participant observation, interviews, documents, photographs, and video. We identified three roles played by the script: (1) protagonist: centralizes creative ideas around its framing; (2) feature player: responsible for mediating creative actions, and (3) antagonist: hinders creative actions. Each of these roles directly influences the different stages of the creative process, which takes place through creativity distributed between people and artifacts. We conclude that artifacts have temporary roles in the creative process, and more than enhancing or limiting this process, they are an integral part of creativity. Therefore, humans and artifacts are entangled in the creative process and should not be analyzed separately.
Managing corporate social responsibility through social learning
Authors: Castillo Maria 
Published: June 2022

AbstractCorporate Social Responsibility (CSR) in the Mexican financial sector is constructed through a social learning process in which four CSR dimensions: influencers; motivations; issues; and outcomes interact, influence each other, and adjust within the boundaries of the Mexican institutional context. By looking at the case of the Mexican financial sector, this paper aims to study how firms engage in the process of managing their corporate social responsibility strategies to generate sustained competitive advantage. It posits that many organizations already consider the different dimensions, but they do so in a siloed way, and that CSR management can be more efficient by engaging in a structured double learning loop that allows firms to adapt their strategy and help them create long‐term value for the firm and its stakeholders. Successfully engaging in social learning can also enhance the firm's legitimacy, but doing so requires strong coordination between different teams and leadership and the capacity to set shared objectives. This research contributes to CSR literature by proposing a model for understanding CSR as a social learning process, and by providing empirical evidence for the understanding of CSR from an emerging country context.
Fracture R‐CNN: An anchor‐efficient anti‐interference framework for skull fracture detection in CT images
Authors: Lin Xian , Yan Zengqiang , Kuang Zhuo , Zhang Hang , Deng Xianbo , Yu Li 
Published: June 2022

AbstractBackgroundSkull fracture, as a common traumatic brain injury, can lead to multiple complications including bleeding, leaking of cerebrospinal fluid, infection, and seizures. Automatic skull fracture detection (SFD) is of great importance, especially in emergency medicine.PurposeExisting algorithms for SFD, developed based on hand‐crafted features, suffer from low detection accuracy due to poor generalizability to unseen samples. Deploying deep detectors designed for natural images like Faster Region‐based Convolutional Neural Network (R‐CNN) for SFD can be helpful but are of high redundancy and with nonnegligible false detections due to the cranial suture and skull base interference. Therefore, we, for the first time, propose an anchor‐efficient anti‐interference deep learning framework named Fracture R‐CNN for accurate SFD with low computational cost.MethodsThe proposed Fracture R‐CNN is developed by incorporating the prior knowledge utilized in clinical diagnosis into the original Faster R‐CNN. Specifically, based on the distributions of skull fractures, we first propose an adaptive anchoring region proposal network (AA‐RPN) to generate proposals for diverse‐scale fractures with low computational complexity. Then, based on the prior knowledge that cranial sutures exist in the junctions of bones and usually contain sclerotic margins, we design an anti‐interference head (A‐Head) network to eliminate the cranial suture interference for better SFD detection. In addition, to further enhance the anti‐interference ability of the proposed A‐Head, a difficulty‐balanced weighted loss function is proposed to emphasize more on distinguishing the interference areas from the skull base and the cranial sutures during training.ResultsExperimental results demonstrate that the proposed Fracture R‐CNN outperforms the current state‐of‐the‐art (SOTA) deep detectors for SFD with a higher recall and fewer false detections. Compared to Faster R‐CNN, the proposed Fracture R‐CNN improves the average precision (AP) by 11.74% and the free‐response receiver operating characteristic (FROC) score by 11.08%. Through validating on various backbones, we further demonstrate the architecture independence of Fracture R‐CNN, making it extendable to other detection applications.ConclusionsAs the customized deep learning–based framework for SFD, Fracture R‐CNN can effectively overcome the unique challenges in SFD with less computational cost, leading to a better detection performance compared to the SOTA deep detectors. Moreover, we believe the prior knowledge explored for Fracture R‐CNN would shed new light on future deep learning approaches for SFD.
Quantitative cerebrovascular reactivityMRIin mice using acetazolamide challenge
Authors: Wei Zhiliang , Li Yuguo , Hou Xirui , Han Zheng , Xu Jiadi , McMahon Michael T. , Duan Wenzhen , Liu Guanshu , Lu Hanzhang 
Published: June 2022

PurposeTo develop a quantitative MRI method to estimate cerebrovascular reactivity (CVR) in mice.MethodsWe described an MRI procedure to measure cerebral vasodilatory response to acetazolamide (ACZ), a vasoactive agent previously used in human clinical imaging. Vascular response was determined by cerebral blood flow (CBF) measured with phase‐contrast or pseudo‐continuous arterial spin labeling MRI. Vasodilatory input intensity was determined by plasma ACZ level using high‐performance liquid chromatography. We verified the source of the CVR MRI signal by comparing ACZ injection to phosphate‐buffered saline injection and noninjection experiments. Dose dependence and feasibility of regional CVR measurement were also investigated.ResultsCerebral blood flow revealed an exponential increase following intravenous ACZ injection, with a time constant of 1.62 min. In contrast, phosphate‐buffered saline or noninjection exhibited a slow linear CBF increase, consistent with a gradual accumulation of anesthetic agent, isoflurane, used in this study. When comparing different ACZ doses, injections of 30, 60, 120, and 180 mg/kg yielded a linear increase in plasma ACZ concentration (p < 0.0001). On the other hand, CBF changes under these doses were not different from each other (p = 0.50). The pseudo‐continuous arterial spin labeling MRI with multiple postlabeling delays revealed similar vascular responses at different postlabeling delay values. There was a regional difference in CVR (p = 0.005), with isocortex (0.81 ± 0.17%/[μg/ml]) showing higher CVR than deep‐brain regions. Mice receiving multiple ACZ injections lived for a minimum of 6 months after the study without noticeable aberrant behavior or appearance.ConclusionsWe demonstrated the proof‐of‐principle of a new quantitative CVR mapping technique in mice.
Deep‐learning synthesized pseudo‐CT for MR high‐resolution pediatric cranial bone imaging (MR‐HiPCB)
Authors: Eshraghi Boroojeni Parna , Chen Yasheng , Commean Paul K. , Eldeniz Cihat , Skolnick Gary B. , Merrill Corinne , Patel Kamlesh B. , An Hongyu 
Published: June 2022

PurposeCT is routinely used to detect cranial abnormalities in pediatric patients with head trauma or craniosynostosis. This study aimed to develop a deep learning method to synthesize pseudo‐CT (pCT) images for MR high‐resolution pediatric cranial bone imaging to eliminating ionizing radiation from CT.Methods3D golden‐angle stack‐of‐stars MRI were obtained from 44 pediatric participants. Two patch‐based residual UNets were trained using paired MR and CT patches randomly selected from the whole head (NetWH) or in the vicinity of bone, fractures/sutures, or air (NetBA) to synthesize pCT. A third residual UNet was trained to generate a binary brain mask using only MRI. The pCT images from NetWH (pCTNetWH) in the brain area and NetBA (pCTNetBA) in the nonbrain area were combined to generate pCTCom. A manual processing method using inverted MR images was also employed for comparison.ResultspCTCom (68.01 ± 14.83 HU) had significantly smaller mean absolute errors (MAEs) than pCTNetWH (82.58 ± 16.98 HU, P < 0.0001) and pCTNetBA (91.32 ± 17.2 HU, P < 0.0001) in the whole head. Within cranial bone, the MAE of pCTCom (227.92 ± 46.88 HU) was significantly lower than pCTNetWH (287.85 ± 59.46 HU, P < 0.0001) but similar to pCTNetBA (230.20 ± 46.17 HU). Dice similarity coefficient of the segmented bone was significantly higher in pCTCom (0.90 ± 0.02) than in pCTNetWH (0.86 ± 0.04, P < 0.0001), pCTNetBA (0.88 ± 0.03, P < 0.0001), and inverted MR (0.71 ± 0.09, P < 0.0001). Dice similarity coefficient from pCTCom demonstrated significantly reduced age dependence than inverted MRI. Furthermore, pCTCom provided excellent suture and fracture visibility comparable to CT.ConclusionMR high‐resolution pediatric cranial bone imaging may facilitate the clinical translation of a radiation‐free MR cranial bone imaging method for pediatric patients.
Evaluation of the bioimpedance technique in newborns with a focus on electrode positioning: A prospective, randomized, crossover study
Authors: Toledo Luana F. M. , Medeiros Thatyana R. , Vieira Alan A. , Coca Velarde Luis Guillermo 
Published: June 2022

AbstractBackgroundBioelectrical impedance analysis (BIA) is a good alternative for assessing total body water in newborns. However, the lack of standardization of the method for its use in the neonatal population raises doubts about its reliability and external validation.ObjectiveTo compare resistance (R) and reactance (Xc) values measured by BIA with electrodes placed in the anatomical position and with electrodes placed at 5‐cm intervals.MethodProspective, randomized, crossover study, in which R and Xc values were measured using monofrequency BIA. The choice of the first position of the electrodes to be analyzed in each NB was performed by a simple randomization, and subsequent measurements were performed in rapid succession. The calculated sample size was 203 evaluations. The paired t test was used to compare the means of R and Xc, and the Bland‐Altman plot and linear regression were used to analyze how much the measured values were influenced by the electrode position.ResultsSignificant differences were found in the R (855.25 ± 147.79 vs 618.95 ± 93.28 Ω) and Xc (50.94 ± 17.34 vs 39.76 ± 18.35 Ω) values measured with electrodes in the anatomical position and at 5‐cm intervals, respectively. The electrodes in the anatomical position produced R and Xc values 37.7% and 16.6%, respectively, higher on average when compared with 5‐cm intervals.ConclusionsThe distance between the electrodes influences the measurement of R and Xc by BIA. These results highlight the importance of defining a standard for the placement of electrodes in newborns for the use of these measures in neonatal clinical practice.
Care burden, coping styles and involvement in care in mothers of autistic children in pandemic of COVID‐19
Authors: Mohammad Fateme , Sani Niloofar , Oshvandi Khodayar , Masoumi Seyedeh Zahra , Khazaei Salman , Bashirian Saeid , Jenabi Ensiyeh , Barati Majid , Rezaei Mohammad , Borzou Seyed Reza 
Published: June 2022

AbstractAimThe aim of the present study was to investigate the burden of care, coping styles and involvement in the care of mothers of autistic children in the pandemic of COVID‐19 in Iranian society.DesignA cross‐sectional study.MethodsA total of 134 mothers completed questionnaires online. Data were analysed by descriptive statistics (frequency, percentage, mean and standard deviation) and independent t‐test, ANOVA and multiple linear regressions. The significance level was considered p < .05.ResultFindings of the study found that burden of care has a strong and direct correlation with involvement in care (p < .001, r = .78) and strongly and indirectly correlated with coping styles (p < .001, r = −.82). Variables of coping styles, involvement in care, mothers' occupation and number of children, age and functional level of autism can predict 81.27% of the variance in care burden in these mothers.
Investigation of the presence and relationship between temporomandibular disorder and oral parafunctions in dental assistant students: A cross‐sectional study
Authors: Eraslan Ravza , Ozturk Taner 
Published: June 2022

AbstractAimIn this cross‐sectional descriptive study, it was aimed to determine the relationship between the prevalence of temporomandibular disorder (TMD) and oral parafunctions in dental assistant students and to evaluate the effects of gender and education years.MethodsThe results of 105 individuals (mean age: 20.72 ± 3.51 years; 75 females, 30 males) were analyzed in this descriptive cross‐sectional study, which included student participants who received dental assistant education program from Erciyes University Vocational Health College. The Fonseca Anamnestic Index (FAI) questionnaire was used to define the presence and symptoms of TMD, and the Oral Behavior Checklist (OBC) questionnaire was used to determine the oral parafunctions of individuals. Fisher's exact, Mann–Whitney U, Kendall tau‐b, and Spearman correlation and linear regression analyses were used to evaluate the data.ResultsAny level of TMD was detected in 64.8% of all individuals included in the study, and most of these patients were women (74.3%). No significant difference was found between the TMD prevalence of the first‐ and second‐grade students based on the years of education of the participants (p = 0.614).   Considering the sex and class parameters, statistically significant weak (r = 0.378 for females; r = 0.375 for the first grade) and middle (r = 0.418 for males; r = 0.478 for the second grade) degree positive correlation was determined (p < 0.01) between the OBC and TMD scores for both parameters.ConclusionThe prevalence of TMD is higher in dental assistant students, especially females, and this is associated with certain degrees of oral parafunctions.