bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heuristics and cognitive biases in the housing investment market
Authors: Cascão Ana , Quelhas Ana Paula , Cunha António Manuel 
Published: July 2022

Purpose
This paper aims to analyze the heuristics and cognitive biases described by behavioral finance in the investment decision-making process of Portugal’s housing market.

Design/methodology/approach
In a first step, the authors applied an exploratory factor analysis (EFA) to assess the impact of heuristics and cognitive biases on investors’ decision-making. In a second step, the authors run a structural equation model (SEM) diagram path to assess if the sociodemographic characteristics of housing market investors determine the identified heuristics and if the heuristics condition the investors’ investment criteria.

Findings
Herd behavior and the heuristics of representativeness, availability and anchoring influence the housing market’s investors’ behavior in their decision-making process. Investors with above-average income show higher levels of overconfidence. Investors showing higher levels of overconfidence also tend to be more sensitive to the house price under analysis for investment. Women tend to show higher levels of the availability and anchoring heuristic. In turn, housing market investors showing higher levels of availability and anchoring heuristic tend to be more sensitive to the price and location of the house under analysis for investment.

Research limitations/implications
The explained variance of the EFA is below 50%, and the root mean square of approximation of the SEM is above the threshold of 0.05. These indicators are evidence of the models’ fragility.

Practical implications
Governments and regulators can better prevent real estate bubbles if they monitor behavioral biases and heuristics of housing investors together with quantitative indicators. Realtors can profit from adapting their marketing strategy and commercial communication to investors of sociodemographic groups more prone to a specific type of heuristics.

Originality/value
To the best of the authors’ knowledge, this is the first study that combines the contributions of behavioral finance with Portugal’s housing investment market and the first study connecting heuristics to investment criteria.
Genesis of an innovation-based entrepreneurial ecosystem: exploring the role of intellectual capital
Authors: Marinelli Luca , Bartoloni Sara , Pascucci Federica , Gregori Gian Luca , Farina Briamonte Massimiliano 
Published: July 2022

PurposeThe aim of the study is to explore the genesis of entrepreneurial ecosystems (EE) and highlight the role played by intellectual capital (IC) in that process. Specifically, the paper adopts the collective intelligence approach, and the study shows how human capital (HC), structural capital (SC) and relational capital (RC) interact to create an entrepreneurial ecosystem.Design/methodology/approachThe paper adopts a single case study of an Italian EE. The data analysis is based upon the collection of different sources of data: semi-structured interviews with representatives of each actor of the ecosystem; email correspondence; meetings report; a 24-months period of direct observation. Given the novelty of the topic, the qualitative method seems well suited for studying innovation-based EE since the method offers rich data about a phenomenon in real-life context.FindingsThe case is a top-down, innovation-based EE in which all main components of the IC play a crucial role from the initial stage. Findings show how the constant interchange between IC components occurs at two different levels: the micro and the meso level. HC and RC play major roles at both levels, whilst SC only occurs at a meso level, representing the environment in which the whole ecosystem takes place. Additionally, the use case, a new intangible asset integrating all three components of IC, emerged as one of the main outcomes of this innovation-based EE.Originality/valueThe paper contributes to a rather unexplored topic in the existing literature on EE and IC, namely the formation process of EE and the role played by IC within that process. Additionally, through the application of the collective intelligence approach, the authors shed light on the need to manage IC at both micro and meso level in the creation of an EE.
Modeling the stochastic volatility of MAD/EURO and MAD/USD the exchange rates by the Bayesian approach and the MCMC (Monte Carlo Markov Chain) algorithm
Authors: Zakaria Firano , Benbachir Anass 
Published: July 2022

PurposeOne of the crucial issues in the contemporary finance is the prediction of the volatility of financial assets. In this paper, the authors are interested in modelling the stochastic volatility of the MAD/EURO and MAD/USD exchange rates.Design/methodology/approachFor this purpose, the authors have adopted Bayesian approach based on the MCMC (Monte Carlo Markov Chain) algorithm which permits to reproduce the main stylized empirical facts of the assets studied. The data used in this study are the daily historical series of MAD/EURO and MAD/USD exchange rates covering the period from February 2, 2000, to March 3, 2017, which represent 4,456 observations.FindingsBy the aid of this approach, the authors were able to estimate all the random parameters of the stochastic volatility model which permit the prediction of the future exchange rates. The authors also have simulated the histograms, the posterior densities as well as the cumulative averages of the model parameters. The predictive efficiency of the stochastic volatility model for Morocco is capable to facilitate the management of the exchange rate in more flexible exchange regime to ensure better targeting of monetary and exchange policies.Originality/valueTo the best of the authors’ knowledge, the novelty of the paper lies in the production of a tool for predicting the evolution of the Moroccan exchange rate and also the design of a tool for the monetary authorities who are today in a proactive conception of management of the rate of exchange. Cyclical policies such as monetary policy and exchange rate policy will introduce this type of modelling into the decision-making process to achieve a better stabilization of the macroeconomic and financial framework.
The impact of implementing visual grammar on learning participle adjectives by EFL learners
Authors: Qadha Adil Mohammed , Al-Wasy Baleigh Qassem 
Published: July 2022

PurposeThis paper aims to examine the impact of using visual grammar on learning participle adjectives by EFL (English as a Foreign Language) learners.Design/methodology/approachThe study follows an experimental design in which two groups participated in the study. The experimental group used visual grammar tools in learning participle adjectives. The control group was taught the participle adjectives in a traditional way. A pre–post test was designed and presented to the participants in the two groups.FindingsThe results showed that the experimental group made statistically significant improvements in their performance in using participle adjectives due to the use of visual grammar tools.Research limitations/implicationsThe current study is only limited to the effect of visual images on a particular grammatical issue, that is participle adjectives. Besides, the study does not include the gender variable; there may be variation in the results depending on the variable of gender.Practical implicationsThe present study can provide language instructors with some guidelines on how to incorporate visual grammar applications in teaching grammar aspects. Learners can also be encouraged to have a better understanding of English grammar, using the different connotations of visual images.Social implicationsUsing visual images in teaching grammar will increase the learners' ability to think beyond their classroom environment. They can use this experience whenever they face visual images in different societal activities.Originality/valueThis paper is one of the initial attempts to investigate the effect of using visual grammar on learning participle adjectives.
Using ecosystem engineers to enhance multiple ecosystem processes
Authors: Byers James E. 
Published: July 2022

Abstract

Ecosystem engineers (EEs) strongly influence ecosystems by affecting the abiotic properties of a system to which many biota respond. EEs can, thus, be pivotal species in restoration by helping to move systems toward desired states much faster and more efficiently than direct human intervention on the abiotic state.

For EEs to play a central, purposeful role in restoration, it is important to identify guiding principles about how the EEs may best be selected and incorporated.

I discuss three important aspects to determine (a) where the utility for EEs is high; (b) where EEs can most easily establish, are easy to handle and scaling‐up their use is possible; and (c) how to recognize and value multiple, coupled and trait‐dependent engineering functions of EEs.

Understanding these aspects of EEs should help guide purposeful and efficient choices in our approach to restoration.

Read the free Plain Language Summary for this article on the Journal blog.
How alcohol makes the epigenetic clock tick faster and the clock reversing effect of abstinence
Authors: Zindler Tristan , Frieling Helge , Fliedner Lena , Veer Ilya M. , Neyazi Alexandra , Awasthi Swapnil , Ripke Stephan , Walter Henrik , Friedel Eva 
Published: July 2022

AbstractThis study investigated the recently reported association between alcohol dependence and accelerated ageing and the potential effects of abstinence and relapse on DNA methylation status using Levine's epigenetic clock to estimate DNA methylation age in two independent cohorts. The first sample comprised 88 (15 female) detoxified patients with alcohol use disorder (AUD) and 32 (5 female) healthy control (CON) subjects (NCT02615977), and the second included 69 (10 female) AUD patients that were followed up for 12 months with respect to relapse (n = 38, 4 female) and abstinence (n = 31, 6 female) (NCT01679145). To account for the different aspects of ageing captured by various clocks, we performed additional analyses of the first‐generation Horvath clock and next‐generation Zhang clock. To account for the genetic liability of AUD and its potential influence on DNA methylation, we calculated a polygenic risk score for alcohol dependence. We found that ageing was accelerated by 3.64 years in AUD patients compared with the CON group according to Levine's DNAm PhenoAge. Furthermore, in a second longitudinal sample, we found that abstaining AUD patients displayed a decrease in DNAm PhenoAge by 3.1 years, but we found an over proportional increase by 2.7 years in those who relapsed. Polygenic risk did not affect epigenetic ageing within our sample. These results confirm the age acceleration associated with AUD and provide the first evidence for a recovery of this effect upon abstinence from alcohol.
Genome‐wide association study revealed ABCD4 on SSC7 and GREB1L and MIB1 on SSC6 as crucial candidate genes for rib number in Beijing Black pigs
Authors: Niu Naiqi , Liu Qian , Hou Xinhua , Liu Xin , Wang Ligang , Zhao Fuping , Gao Hongmei , Shi Lijun , Wang Lixian , Zhang Longchao 
Published: July 2022

AbstractAs one of the few animals with variation in the number of rib pairs (RIB), the pig is a good model to study the mechanism of RIB regulation. Quantitative trait loci (QTL) for porcine RIB are present on Sus scrofa chromosome 7 (SSC7). Although several candidate genes exist in this QTL region on SSC7, the causal gene has yet to be verified. Beijing Black pig with 14–17 RIB is a good population for candidate gene mining and 1104 individuals were genotyped using the Illumina Porcine 50K BeadChip. A total of 14 SNPs from 95.49 to 97.78 Mb on SSC7 showed genome‐wide significant association with RIB. On SSC7, a locuszoom plot using pairwise linkage disequilibrium displayed the narrowest linkage region encompassing only two genes, ABCD4 and VRTN. In mice, a transcriptome expression profile was obtained using three embryos at E9.5 (the critical period for rib formation). ABCD4 was highly expressed, but no expression of VRTN was detected. On SSC6, there were four genome‐wide significant SNPs from 106.42 to 106.92 Mb associated with RIB. GREB1L and MIB1, in this region, were regarded as novel candidate genes. These results revealed a crucial candidate causal gene on SSC7 and novel genes on SSC6 for rib number and provided interesting new insights into its genetic basis.
Influence of tapentadol and oxycodone on the spinal cord and brain using electrophysiology: a randomized, placebo‐controlled trial
Authors: Nedergaard Rasmus Bach , Hansen Tine Maria , Mørch Carsten Dahl , Niesters Marieke , Dahan Albert , Drewes Asbjørn Mohr 
Published: July 2022

AimsThe aim of this study was to investigate the effects of tapentadol and oxycodone using the nociceptive withdrawal reflex and sensory evoked potentials.MethodsTwenty‐one healthy volunteers completed a cross‐over trial with oxycodone (10 mg), tapentadol (50 mg) extended‐release tablets, or placebo treatment administered orally BID for 14 days. Electrical stimulations were delivered on the plantar side of the foot to evoke a nociceptive withdrawal reflex at baseline and post‐interventions. Electromyography, recorded at tibialis anterior, and electroencephalography were recorded for analysis of: number of reflexes, latencies, and area under the curve of the nociceptive withdrawal reflex as well as latencies, amplitudes and dipole sources of the sensory‐evoked potential.ResultsTapentadol decreased the odds ratio of eliciting nociceptive withdrawal reflex by −0.89 (P = .001, 95% confidence interval [CI] −1.46, −0.32), whereas oxycodone increased the latency of the N1 component of the sensory‐evoked potential at the vertex by 12.5 ms (P = .003, 95% CI 3.35, 21.69). Dipole sources revealed that the anterior cingulate component moved caudally for all three interventions (all P < .02), and the insula components moved caudally in both the oxycodone and tapentadol arms (all P < .03).ConclusionA decrease in the number of nociceptive withdrawal reflex was observed during tapentadol treatment, possibly relating to the noradrenaline reuptake inhibition effects on the spinal cord. Both oxycodone and tapentadol affected cortical measures possible due to μ‐opioid receptor agonistic effects evident in the dipole sources, with the strongest effect being mediated by oxycodone. These findings could support the dual effect analgesic mechanisms of tapentadol in humans as previously shown in preclinical studies.
Present and future avenues of cell‐based therapy for brain injury: The enteric nervous system as a potential cell source
Authors: Hacene Sirine , Le Friec Alice , Desmoulin Franck , Robert Lorenne , Colitti Nina , Fitremann Juliette , Loubinoux Isabelle , Cirillo Carla 
Published: July 2022

AbstractCell therapy is a promising strategy in the field of regenerative medicine; however, several concerns limit the effective clinical use, namely a valid cell source. The gastrointestinal tract, which contains a highly organized network of nerves called the enteric nervous system (ENS), is a valuable reservoir of nerve cells. Together with neurons and neuronal precursor cells, it contains glial cells with a well described neurotrophic potential and a newly identified neurogenic one. Recently, enteric glia is looked at as a candidate for cell therapy in intestinal neuropathies. Here, we present the therapeutic potential of the ENS as cell source for brain repair, too. The example of stroke is introduced as a brain injury where cell therapy appears promising. This disease is the first cause of handicap in adults. The therapies developed in recent years allow a partial response to the consequences of the disease. The only prospect of recovery in the chronic phase is currently based on rehabilitation. The urgency to offer other treatments is therefore tangible. In the first part of the review, some elements of stroke pathophysiology are presented. An update on the available therapeutic strategies is provided, focusing on cell‐ and biomaterial‐based approaches. Following, the ENS is presented with its anatomical and functional characteristics, focusing on glial cells. The properties of these cells are depicted, with particular attention to their neurotrophic and, recently identified, neurogenic properties. Finally, preliminary data on a possible therapeutic approach combining ENS‐derived cells and a biomaterial are presented.
Anticancer activities of Brachydin C in human prostate tumor cells (DU145) grown in 2D and 3D models: Stimulation of cell death and downregulation of metalloproteinases in spheroids
Authors: Oliveira Larissa Cristina Bastos de , Ribeiro Diego Luis , Nascimento Jessyane Rodrigues do , Rocha Claudia Quintino da , Cólus Ilce Mara de Syllos , Serpeloni Juliana Mara 
Published: July 2022

AbstractBrachydin C (BrC) has demonstrated in vitro cytotoxic and antiproliferative effects in prostate cancer cells. In the present study, we compare the anticancer effects of BrC in DU145 cells grown in common bidimensional cultures (2D) and multicellular tumor spheroids (MCTS), often denominated 3D in vitro models, that can better mimic the microenvironment of tissues. BrC IC50 values obtained in the resazurin assay after 24 h of treatment were 47.31 μM (2D) and 229.8 μM (3D) and these cytotoxic effects were time‐dependent only in 3D. BrC (5.0–60 μM) interfered with the growth of MCTS and reduced cell viability after 11 days of treatment, a result that is not attributable to oxidative stress evaluated using the CM‐H2DCFDA probe. BrC (6.0 μM) impaired horizontal (wound‐healing) and vertical cell migration and invasion (transwell assay) in 2D and BrC (5.0–60 μM) in 3D (ECM Gel®). BrC modulated the expression of genes BIRC5, TNF‐α, CASP3, NKX3.1, MMP9, MMP11, CDH1, and ITGAM and downregulated proteins CASP7, BAX, and TNF‐α in Western blotting analysis. In conclusion, BrC stimulated cell death and decreased epithelial–mesenchymal transition. Furthermore, DU145 MCTS displayed higher resistance to BrC‐induced cell death than 2D cultures, a difference that should be considered in future approaches in prostatic cancer studies.
Shaping the future of teledermatology: a literature review of patient and provider satisfaction with synchronous teledermatology during the COVID-19 pandemic
Authors: Miller John , Jones Elizabeth 
Published: July 2022

Abstract
Following the onset of the COVID-19 pandemic, widespread adoption of synchronous teledermatology (e.g. live video conferencing) has increased patient and provider familiarity with the method. To our knowledge, no teledermatology reviews have exclusively characterized patient and provider satisfaction with synchronous models of teledermatology. This study quantitatively evaluated patient and provider satisfaction through a literature review of synchronous teledermatology studies conducted during the COVID-19 pandemic. We undertook a review of the literature using the PubMed database, which was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search terms included, but were not limited to, ‘teledermatology’, ‘patient satisfaction’ and ‘provider satisfaction’. Studies were evaluated for quality of evidence, based on guidelines described by the Oxford Centre for Evidence-based Medicine. In total, 15 studies satisfied the inclusion criteria, and described the satisfaction of 7871 patients and 146 providers with synchronous teledermatology during the COVID-19 pandemic. Patients and providers were overall satisfied with access measures, the patient–provider relationship and the ability of synchronous teledermatology to meet patient needs. Limitations of the virtual physical examination and image/video quality were consistent limiting factors for the patient and provider experience, respectively. Patients and providers perceive that synchronous teledermatology can meet the needs of the patient. Patients perceived a satisfactory patient–provider relationship through synchronous teledermatology. Practices can identify best applications and educate patients on expectations of the virtual examination in order to enhance the use and sustainability of synchronous teledermatology beyond the pandemic.
The benefits of initiating continuous renal replacement therapy after brain death in organ donors with oligoanuric acute kidney injury
Authors: Marklin Gary F. , Ewald Laura , Klinkenberg W. Dean , Joy Christina M. , Bander Steven J. , Rothstein Marcos 
Published: July 2022

AbstractAcute kidney injury (AKI) in deceased organ donors is increasing due to the escalation in anoxic brain‐deaths. The management of an organ donor with oligoanuric AKI is frequently curtailed due to hemodynamic and electrolyte instability. Although continuous renal replacement therapy (CRRT) corrects the effects of AKI, it is rarely started after the diagnosis of brain‐death (BD). Since 2017, we have initiated CRRT in organ donors with oligoanuric AKI to allow more time to stabilize the donor and improve the function of the thoracic organs. We now report our experience with the first 27 donors with oligoanuric AKI that received CRRT after the diagnosis of BD, with organs transplanted as the primary outcome. The average duration of CRRT was 30.1 ± 14.4 h and the mean ultrafiltration volume was 5141 ± 4272 ml. The time from BD declaration to cross clamp was significantly longer in the CRRT group versus a historical cohort with oligoanuric AKI that was not dialyzed (62.8 ± 18.3 vs. 37.1 ± 14.9 h;P < .01). The mean number of total organs transplanted per donor in the CRRT group was greater than the historical cohort, 2.9 ± 1.7 vs. 1.4 ± .6 (P = .< 01), respectively. The mean number of thoracic organs transplanted per donor also increased between the two groups, 1.4 ± 1.2 versus .6 ± .9 (P = .02). Thirty‐seven percent of the kidneys were successfully transplanted with a mean serum creatinine of 1.4 mg/dl at 6 months. We suggest that OPOs consider starting CRRT in organ donors with oligoanuric AKI to possibly increase the number of organs transplanted.
Rewilding life together: Bonhoeffer, spirituality, and interspecies community
Authors: Dahill Lisa E. 
Published: July 2022

AbstractIn a time of grave ecological danger, compounding injustices, and resource stresses threatening entire human and ecosystemic populations, we need new forms of life together, an intentional interspecies weirding of inherited religious visions of community. The recent turn toward place‐based thinking orients our gaze back to the actual places we live, learning again to see, love, and sustain relationships with their creatures and elements. This article stands within that larger development of place‐based hermeneutics: engaging Dietrich Bonhoeffer's Life Together toward an interspecies broadening of what Christian community means. Such life together takes distinctive shape in each particular place: here, the fire‐charred chaparral and car‐centered built world of southern California, haunted by European settlers’ annihilation of the local indigenous humans, grizzlies, and groundwater, ground zero now for climate‐, pandemic‐, extinction‐, and immigrationjustice challenges. The article's process generates new insights in the study of Bonhoeffer's legacy and hermeneutical strategies useful for other projects in place‐based (re‐) readings of classic texts in Christian spirituality.