bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Journey for Hypertension and Dyslipidemia in Saudi Arabia: Highlighting the Evidence Gaps
Authors: Amir Ashraf , Alasnag Mirvat , Al-Raddadi Rajaa , Al-Bassam Tawfik , Saeed Kanwal , Yazıcıoğlu Mehmet , Shabana Ayman 
Published: July 2022

Abstract
Background
In recent years, Saudi Arabia has witnessed staggering rates of hypertension and dyslipidemia- related cardiovascular (CV) deaths, overburdening the healthcare ecosystem of the country. Appropriate public health interventions can be devised through quantitative mapping of evidence. Identification of potential data gaps can prioritize future research needs and develop a ‘best-fit’ framework for patient-centric management of hypertension and dyslipidemia.
Methods
This review quantified data gaps in the prevalence and key epidemiological touchpoints of the patient journey including awareness, screening, diagnosis, treatment, adherence, and control in patients suffering from hypertension and dyslipidemia in Saudi Arabia. Studies published in English between January 2010–December 2021 were identified through a structured search on MEDLINE, Embase, BIOSIS and PubMed databases. An unstructured search on public and government websites including Saudi Ministry of Health without date limits was carried out to fill data gaps. After exclusion of studies based on pre-defined criteria, a total of 14 studies on hypertension, 12 studies and one anecdotal evidence for dyslipidemia were included in the final analyses.
Results
The prevalence of hypertension was reported to be 14.8–41.8% while that for dyslipidemia was 12.5–62.0%, respectively. The screening rate for hypertension was 100.0% as revealed by the nationwide surveys. Among hypertensive patients, only 27.6–61.1% patients were aware of their condition, 42.2% patients underwent diagnosis, 27.9–78.9% patients received antihypertension treatment, 22.5% patients adhered to treatment medication while blood pressure (BP) control was achieved in 17.0–45.0% patients. Likewise, among patients with dyslipidemia, 10.5–47.3% patients were aware of their condition, 34.6% patients were screened and 17.8% underwent diagnosis. Although high treatment rates ranging from 40.0–94.0% were reported, medication adherence recorded was 45.0–77.4% among the treated patients. The overall control rates ranged from 28.0–41.5%.
Conclusions
The study findings highlight evidence gaps along key touchpoints of patient journey touchpoints. Reinforcing the efforts for high-quality evidence-based research at a national level may pave a path for better resource utilization and provide guidance to practice and amend health policies for patients, healthcare practitioners (HCPs) and healthcare policy makers for better patient outcomes in Saudi Arabia.
Static and free vibration analysis of gravity dam under the influence of hydrostatic pressure using ANSYS finite element models
Authors: name Pandimani no family , Vipparthy Ravindra 
Published: July 2022

Abstract
Dams are considered to be very important structures as they play an important role in the economic and social development of the area in which it is being constructed as well as utilized for hydropower generation. The concrete gravity dam is a solid structure that retains its stability against the design loads through its self-weight alone. The dam considered in this study is a structure of the Indirasagar polavaram gravity dam which is located in the village called Ramayyapeta comes under the West Godavari District, Andhra Pradesh. In this study, the finite element (FE) method is employed to numerically analyze the 2-D concrete gravity dam. The main objective of this study is to perform a linear FE analysis of the Indirasagar Polavaram gravity dam by varying the upstream hydrostatic pressure with constant downstream tailwater pressure. In the static analysis parameters like displacements, stresses and strains are assessed at each node, and their corresponding distributions are noticed. Subsequently, in the dynamic analysis approach, only free vibration analysis (Modal analysis) is done by considering only the dam's weight, the first five-mode shapes and their respective natural frequencies are extracted using ANSYS. The linear material behavior of the dam is modeled using the quadrilateral 4 node PLANE182 elements and the hydrostatic pressure is applied as triangular distribution. From the numerical analysis, it is concluded that the maximum tensile stresses are accumulated at the heel portion of the dam for cases 1 to 4, whereas it is observed distributed along the dam base for the rest of the cases. The lateral displacement and strain are observed maximum for case 1. The First mode's natural frequency of 5.81 Hz is ascertained and the maximum frequency and displacement are produced under the fifth mode.
Generating and Choosing Organisations for Multi-Agent Systems
Authors: Amaral Cleber Jorge , Hübner Jomi Fred , Cranefield Stephen 
Published: July 2022

Abstract
The design of organisations is a complex and laborious task. It is the subject of recent studies, which define models to automatically perform this task. However, existing models constrain the space of possible solutions by requiring a priori definitions of organisational roles and usually are not suitable for planning resource use. This paper presents GoOrg, a model that uses as input a set of goals and a set of available agents to generate different arrangements of organisational structures made up of synthesised organisational positions. The most distinguishing characteristics of GoOrg are the use of organisational positions instead of roles and that positions are automatically synthesised rather than required as a priori defined inputs. GoOrg qualifies the generated structures according to multiple attributes; These characteristics facilitate the parametrisation, the use for resource planning and the chance of finding feasible solutions. This paper also introduces two model specialisations, which define processes and constraints that illustrate how GoOrg suits different domains. Among aspects that surround an organisation design, this paper discusses models' input, agents' abstractions and procedures for adapting the organisation during its life-cycle.
Self-DNA accumulation as a risk factor for accelerating the pathogenesis of rheumatoid arthritis in elderly individuals
Authors: Luo Weidan , Wong Vincent Kam Wai 
Published: July 2022

Abstract
Ageing is an unavoidable process in humans and a major factor for the increasing risk of various diseases. In the United States, more than 50% of rheumatoid arthritis patients are middle-aged or elderly, but the risk factors and mechanisms by which ageing increases the incidence of rheumatoid arthritis are not known. It has been suggested that the accumulation of DNA fragments increases the risk of autoimmune diseases, such as systemic lupus erythematosus. DNA fragments are a common nucleic acid metabolite in ageing organisms as well as in the serum of humans and animals with rheumatoid arthritis; therefore, we hypothesize that DNA fragments are one of the factors contributing to the development of rheumatoid arthritis due to ageing. First, we analysed two in vitro DNA damage response models by using a gene silencing approach and determined that the DNA fragment clearance gene TREX1 can regulate inflammatory factor release in normal cells. Second, after TREX1 expression was knocked down locally or systemically in rats via the Cre-LoxP system and compared with that in AIA (adjuvant-induced arthritis) model rats treated with AAV-TREX1, it was determined that DNA fragments can result in manifestations of arthritis and abnormal activation of the immune system in rats. These results, including the low expression of the TREX1 gene in clinical patient and AIA model samples and the results of immunohistochemical, Western blot, and transcriptome analyses, revealed that the TREX1 gene can regulate cellular senescence-associated secretory phenotype (SASP)-related manifestations and showed that dysregulation of c-Jun and c-Fos, components of the TREX1 transcription factor AP-1, is associated with SASP induction. Finally, it was confirmed in vitro that different causes of decreased c-Fos expression can inhibit TREX1 expression. These DNA fragments are potent producers of inflammation-releasing mediators, and TREX1 is an effective degrader of DNA fragments; it is also a key gene that regulates cellular immunity and ageing. Therefore, effectively clearing excess DNA fragments from the body and ensuring the health of senescent cells may be a potential prevention strategy for RA.
The Quality Problems in Low İrradiance at Grid Connected PV Solar System
Authors: adak suleyman 
Published: July 2022

Abstract
Photovoltaic (PV) energy is one of the main topics that have attracted the attention of researchers in recent years. The use of solar energy is increasing rapidly in the world. Although PV energy has many advantages, it has some disadvantages. Among these disadvantages, power factor (PF) and Total Harmonic Distortion (THD) issues are discussed in this article. PF and THD are dependent on the radiation values. The solar inverter output voltage and current waveform should be in sinusoidal waveform. However, the sinusoidal waveform of current and voltage lose their sinusoidal characteristics due to non-linear loads on grid-connected solar system. Harmonic components often occur in grid-connected solar PV systems. In addition, at low irradiance the amplitude of harmonic components increases, whereas the power factor of the PV system decreases. Low power factor and high amplitude of harmonics cause the efficiency of the solar system to decrease. PF and THD values were measured in a particular cloudy day for analysis. The grid-connected PV system was modeled by using Matlab /simulation program and carried out the analysis of the solar PV system. Thus, the analytical expression of the PF and THDI dependent on irradiation were found with a new method by using statistical package for the social sciences (SPSS) program and curve fitting method.
Methylphenidate dose-response in children with ADHD: Evidence from a double-blind, randomized placebo-controlled titration trial
Authors: Vertessen Karen , Luman Marjolein , Swanson James M. , Bottelier Marco , Stoffelsen Reino , Bet Pierre , Wisse Annemiek , Twisk Jos W.R. , Oosterlaan Jaap 
Published: July 2022

Abstract
Background
Methylphenidate (MPH) is highly efficacious in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD) in children. Generally higher doses are found to result in better symptom control, however, it remains unclear whether this pattern can be observed at the individual level, given the large heterogeneity in individual dose-response relationships and observed placebo responses.
Methods
A double-blind, randomized, placebo-controlled cross-over trial was used to compare weekly treatment with placebo and 5, 10, 15 and 20 mg of MPH twice daily on parent and teacher ratings of child ADHD symptoms and side effects. Participants were 5–13 year old children with a DSM-5 diagnosis of ADHD (N = 45). MPH response was assessed at group and individual levels and predictors of individual dose-response curves were examined.
Results
Mixed model analysis showed positive linear dose-response curves at group level for parent and teacher rated ADHD symptoms and parent rated side effects, but not for teacher rated side effects. Teachers reported all dosages to improve ADHD symptoms compared to placebo, while parents only reported > 5 mg/dose as effective. At the individual level, most (73–88%) children showed positive linear dose-response curves. Higher severity of hyperactive-impulsive symptoms and lower internalizing problems, lower weight, younger age and more positive opinions towards diagnosis and medication partly predicted steeper linear individual dose-response curves.
Conclusions
Our study confirms that higher doses of MPH yield greater symptom control at a group level. However, large interindividual variation in the dose-response relationship was found and higher doses did not lead to greater symptom improvement for all children.
Reusable titania-SBA-15 photocatalyst synthesized by different silica/titania ratios for enhancing methylene blue photodegradation
Authors: Göl Sevgi Can , Akbay Elif 
Published: July 2022

Abstract
In this study, a series of TiO2/SBA-15 photocatalysts were synthesized with different Si/Ti ratios by a one-step hydrothermal method with TiO2 nano-powder as a titanium source. These materials were characterized by XRD, SEM-EDX, N2 adsorption-desorption isotherms-desorption isotherms, XRF, and UV-DRS analysis. During the synthesis of TiO2/SBA-15s, the SBA-15 pore structure and channels did not deteriorate, and the Si/Ti molar ratios are close to the expected nominal ratios. SBA-15 and TiO2/SBA-15s exhibited a uniform- narrow pore size distribution, but TiO2/SBA-15s pore size shifted to a smaller range, and the BET area values of TiO2/SBA-15s materials are in the range of the 621–583 m2/g. TiO2 nanocrystals into the SBA-15 mesopores walls wall up to the ratio of Si/Ti = 16. With high TiO2 loading of that value, clogging occurs in the SBA-15 pores. The optical band gap energies were significantly blue-shifted which is the quantization effects improving the photocatalytic activities Photocatalytic activities of TiO2/SBA-15s were evaluated by degradation of methylene blue under UV-light irradiation at constant TiO2 content. The highest efficiency was obtained in the TiO2/SBA-15 (16) photocatalyst at 79.6%, and all efficiencies in synthesized photocatalyst are higher than bulk TiO2 photocatalyst activity (27.52%) due to the poor dispersion of active phases. Reused photocatalyst has no activity losses for five runs and may be used for long periods without loss of activity. For the stability of the photocatalyst, a combination of XRD, SEM, and N2 adsorption-desorption isotherms was employed after the fifth run. These results demonstrate that the photocatalyst activity and stability are good, and photocatalytic activity was sustainable after reuse for several cycles.
The Physical Properties Study of The Hybrid One-Part Alkali-Activated Mortar
Authors: Yusslee Eddy Mohd Fairuz Mohd , Beskhyroun Sherif 
Published: July 2022

Abstract
One-part alkali-activated materials (AAMs) are an alternative material to respond to the shortcoming of the conventional two-part systems. One-part AAMs are more practical and safer to handle from transporting to the casting stage on site. It can be applied in the form of paste, mortar, and concrete, providing more options than an ordinary cement binder. The most common aluminosilicate precursors sources for the one-part AAMs are the combination or single raw material of fly ash, ground granulated blast furnace slag and metakaolin. However, it was found that the one-part AAMs experienced high porosity levels primarily due to their inconsistent pore structures that affect their long-term performance. One-part AAMs mortar is one of the cementitious products used as concrete repair materials that may be affected by these weaknesses. Nevertheless, the combination of aluminosilicate precursor by-products with the ordinary Portland cement or hybrid AAMs help to develop a robust performance mainly used as a patching product for concrete repair materials. This hybrid one-part AAMs mortar can be composed with other admixtures with a suitable mix design to ensure its stability and useable in the form of a fresh and hardened state. Unlike the ordinary concrete, hybrid one-part AAMs have significantly strengthened growth beyond the 28th day. In this study, the mechanical strength of the mortar increased over time up to 63 N/mm2 at 56 days of curing age, shorter setting time and workable comparable to the control samples. In addition, the water to binder ratio of 3.0 activated the dry mixes and significantly improved the physical and microstructure of the hybrid one-part AAMs mortar.
Does corruption affect private firm performance in Uzbekistan?
Authors: Suyunov Alisher , Amanova Maftuna 
Published: July 2022

Abstract
The study investigates the impact of corruption on private firm performance in Uzbekistan. The results point up a negative relationship between corruption and firms performance in Uzbekistan. We found the perceived corruption deteriorates firms’ performance and decreases firms’ total annual sales by 28.8% in private firms in Uzbekistan. The study enriches existing empirical studies examining the effect of corruption on firm performance in the context of various countries and regions.
Quality of household drinking water and its associated risk factors in flood-prone settings of Northwest Ethiopia: a cross-sectional community-based study.
Authors: Birhan Tsegaye Adane , Destaw Bikes , Dagne Henok , Eyachew Dagnachew , Azanaw Jember , Andualem Zewudu , Dessie Awrajaw , Guyasa Gebisa , Getaneh Alem , Addisu Ayenew , Genet Mengesha , Tadege Garedew , Tesfaye Amensisa Hailu 
Published: July 2022

Abstract
Background: Drinking water quality deterioration is a big issue in many countries which could be a result of many interconnected biological, physical, and chemical factors. The main contaminants of water sources are human excreta, animal waste, and effluent agricultural practices. Even if the source is safe, water may also become faecally contaminated during collection, transportation, storage, and drawing in the home. Furthermore, a better water source does not lead to full health benefits in the absence of improved water storage and sanitation. Therefore, Regular quality control mechanisms need to be in place. The objective of this study is therefore to determine the level of physioco-chemical and bacteriological quality of household drinking water and its associated factors in flood-prone settlements of South Gondar Zone, Ethiopia.Methods: A community-based cross-sectional study was conducted in flood-prone settlements of the South Gondar Zone from January to March 2021. Household water samples were taken from each household using standardized water sampling techniques. Face-to-face interview using structured questionnaires was used to collect socio-economic and behavioral data. Univariate and multivariate analyses were done using logistic regression models.Results: A total of 675 households participated in the study. The prevalence of positive fecal coliform in household water samples in flood-prone settlements of the South Gondar Zone was found to be 62.2% (n=417) with [95% CI (53-60)]. In multivariate analysis, family size [AOR=2.205, 95%CI (1.375-3.536)], presence of latrine [AOR=3.449, 95%CI (1.349-8.823)], and having a separate can to take water from its storage [AOR=0.454, 95%CI (0.249-0.827)] are variables identified as predictors for fecal coliform contamination of household water.Conclusion: In this study, the prevalence of positive fecal coliform household water was high. Family size, the presence of a latrine, and having a separate can to take water from its storage had significant associations with the presence of fecal coliform in household drinking water.
Las emociones y su relevancia moral y política
Authors: Grajales Usuga Martha Elena 
Published: July 2022

El propósito de este texto es hacer un análisis de las actuales teorías de las emociones de Agnes Heller, Martha Nussbaum y Peter Hacker y los argumentos que proponen para rehabilitar las emociones dentro del campo moral y político. Para cumplir con este objetivo, primero, se analizan los argumentos que los tres filósofos proponen para sustentar la idea de que las emociones son importantes para la supervivencia y el desarrollo de la vida humana. Segundo, se explica lo que quieren decir los autores al definir las emociones como fenómenos cognitivos. Tercero, se muestra la incidencia de la sociedad y la cultura en el aprendizaje y en la vivencia de las emociones. A partir de estas aclaraciones previas, la cuarta sección está dedicada a mostrar más precisamente el entretejimiento entre emociones, moral y política. Se concluye que a pesar de las diferencias conceptuales y metodológicas que existen entre los tres filósofos, su obra permite trazar coincidencias y complementaciones que dan un sólido sustento a la tesis de que las emociones son imprescindibles para la vida humana y su comportamiento moral y político. También que los resultados de esta puesta en diálogo son un marco conceptual que puede orientar trabajos más específicos sobre la relación del mundo afectivo y el mundo social y político.
Knowledge and Awareness regarding Dental Management of Hemophilic Patients among Students of a Malaysian University: A Cross-Sectional Study
Authors: George Ann Mary , Mayya Anoop , Mayya Arun , Iszham Azzura Binti , Rafi Nur Hanna Binti Moh’d , Marius Royle , Mayya Shreemathi S. 
Published: July 2022

Background:
Improper management of bleeding disorders in the dental setting can lead to complications that can endanger the lives of such patients.

Objective:
This study aimed to assess the knowledge and awareness of dental management of hemophilia among undergraduate students of a Malaysian university.

Methodology:
A cross-sectional survey was conducted in the year 2018-2019 to collect the data. A 23-item questionnaire developed and validated by the authors was used to collect data on the knowledge and awareness regarding dental management of hemophilia patients. A total of 216 dental students participated in this research. Unpaired t-test and one-way ANOVA were used to compare the knowledge score between gender and academic year.

Results:
Only 21% of the participants were confident in treating a hemophilia patient. About 97% of the participants believed that the dental curriculum must be modified to emphasize the dental management of bleeding disorders. The overall mean of the knowledge score was 47.38% and awareness was 73.7% regarding the management of patients with hemophilia.

Conclusion:
The study revealed significant scope for improvement in the dental students' knowledge, which can be achieved by modifying the dental curriculum suitably to provide more emphasis on the management of bleeding disorders.
Caso: beneficios económicos por lograr transferencia tecnológica de una patente en una universidad latinoamericana
Authors: Flores Cadena Gary 
Published: July 2022

Muchas universidades latinoamericanas han desarrollado varias innovaciones en patentes y servicios, generando desarrollos fáciles de comercializar para conseguir ingresos; sin embargo, la falta de un adecuado enfoque del sistema de transferencia tecnológica efectivo, al igual que una referencia que permita proponer un valor de venta cierto sobre esas innovaciones y patentes, les impiden obtener beneficios económicos de estos productos y servicios de empresas públicas y privadas.
En el presente estudio se propone un método técnico que, sumado a un sistema efectivo de transferencia tecnológica que permita cuantizar el potencial de las universidades y lograr que las innovaciones, servicios y desarrollos que producen se comercialicen eficazmente. Para ello se cuantiza todo el potencial que posee la universidad, evaluando todos los aportes de personal, grupos de investigación, laboratorios, etc., para luego pesar los mejores referentes y con mayor potencial para comercializarse.
Como las universidades públicas buscan generar el mayor beneficio a la sociedad en productos y servicios sin afán de lucro, en ese caso se propone medir el verdadero impacto de esos beneficios a través de índices que cuantifiquen la masa social a la que impactan. Empleando como ejemplo una patente de invención desarrollada por Escuela Politécnica Nacional del Ecuador, se realiza el cálculo del valor de venta y la proyección de réditos que recibiría la universidad, que puede servir como ejemplo para otras universidades latinoamericanas.