bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matching to Categories: Learning and Compliance Costs in Administrative Processes
Authors: Moynihan Donald , Giannella Eric , Herd Pamela , Sutherland Julie 
Published: January 2022

Abstract
A perennial task for the state is the creation and policing of categories. State-created categories have real world impacts on the public. The consequences of racial categorizations, for example, are well-documented. We examine a less studied consequence of state categorization, which are the administrative burdens created when individuals attempt to match themselves to state-created categories. Matching requires time and effort, and failure to match to an advantageous category can mean a loss of material benefits. The matching problem may sometimes result from obscure categories, or an overwhelming number of categories. The matching problem is also amplified when the state uses identity categories—such as self-employed or unemployed, a retiree, parent, spouse or disabled—where individuals hold pre-existing beliefs about such identities that map poorly onto equivalent state categorizations. To study the matching problem and ways to reduce it, we undertook a field experiment in a California welfare program, CalFresh, the state version of the Supplemental Nutrition Assistance Program (SNAP). Claimants often fail to select into the category of “self-employed” even though it would be more favorable for them to do so. We show how a more intuitive presentation of information about the category and its benefits increased the rate of those identifying as self-employed from 8.8% to 12.1%, approximately one-third. We also show that providing a simple self-attestation template to convey information about self-employment status, a means of reducing compliance costs while meeting state documentation requirements, increased the number of claimants providing an acceptable form of documentation to match to the category. The results show that people frequently lack an intuitive understanding of state categories, that the presentation of categories can reduce this matching problem, and that the state can make it easier to document the match.
Pattern of chromosomal aberrations persisting over 30 years in a Chernobyl Nuclear Power Plant accident survivor: study using mFISH
Authors: Nikitina Victoriya , Nugis Vladimir , Astrelina Tatiyana , Zheglo Diana , Kobzeva Irina , Kozlova Mariya , Galstyan Irina , Lomonosova Elena , Zhanataev Aliy , Karaseva Tatiyana , Samoylov Alexander S 
Published: January 2022

Abstract
The long-term in vivo cytogenetic effects of high-dose radiation exposure can be traced in accidentally irradiated persons, and particularly useful for developing strategies of monitoring and therapy of such patients, as well as for elucidating the fundamental aspects of hematopoiesis and radiobiology. Using 24-color fluorescent in situ hybridization (mFISH), we analysed the frequency and the spectrum of chromosomal aberrations (CA) in peripheral blood lymphocytes of the Chernobyl Nuclear Power Plant (NPP) accident victim 30, 31, 32 and 33 years after acute accidental exposure to high-dose gamma radiation of the whole body. Totally, 993 metaphase cells were analyzed (or 219, 272, 258, 244 cells each year), of which 297 were aberrant. Our study demonstrated a constant aberrant cell frequency at 28% in 2016–2018 years, while in 2019, a significant increase up to 35% occurred due to contribution of significantly elevated frequency of simple aberrations in the absence of evident recent genotoxic factors. Four clonal aberrations were detected, three of which persisted for more than one year at a frequency up to 2.5% of analyzed cells. The distribution of 731 breakpoints per individual chromosomes was nearly proportional to their physical length, excepting Chromosomes 13 and 20, which were significantly breakpoint-deficient compared to the genome median rate. Monitoring of the long-term effects on chromosomal instability caused by radiation exposure is important for understanding and predicting the long-term effects of ionizing radiation.
Black hole–galaxy scaling relations in FIRE: the importance of black hole location and mergers
Authors: Çatmabacak Onur , Feldmann Robert , Anglés-Alcázar Daniel , Faucher-Giguère Claude-André , Hopkins Philip F , Kereš Dušan 
Published: January 2022

ABSTRACT
The concurrent growth of supermassive black holes (SMBHs) and their host galaxies remains to be fully explored, especially at high redshift. While often understood as a consequence of self-regulation via AGN feedback, it can also be explained by alternative SMBH accretion models. Here, we expand on previous work by studying the growth of SMBHs with the help of a large suite of cosmological zoom-in simulations (MassiveFIRE) that are part of the Feedback in Realistic Environments (FIRE) project. The growth of SMBHs is modelled in post-processing with different black hole accretion models, placements, and merger treatments, and validated by comparing to on-the-fly calculations. Scaling relations predicted by the gravitational torque-driven accretion (GTDA) model agree with observations at low redshift without the need for AGN feedback, in contrast to models in which the accretion rate depends strongly on SMBH mass. At high redshift, we find deviations from the local scaling relations in line with previous theoretical results. In particular, SMBHs are undermassive, presumably due to stellar feedback, but start to grow efficiently once their host galaxies reach M* ∼ 1010M⊙. We analyse and explain these findings in the context of a simple analytic model. Finally, we show that the predicted scaling relations depend sensitively on the SMBH location and the efficiency of SMBH merging, particularly in low-mass systems. These findings highlight the relevance of understanding the evolution of SMBH-galaxy scaling relations to predict the rate of gravitational wave signals from SMBH mergers across cosmic history.
Magnetic field topology, chemical spot distributions, and photometric variability of the Ap star φ Draconis
Authors: Kochukhov O , Papakonstantinou N , Neiner C 
Published: January 2022

ABSTRACT
The primary component of the multiple star φ Dra is one of the brightest magnetic chemically peculiar stars in the northern sky. Here, we report results of a comprehensive study of the rotational photometric variability, binarity, magnetic field geometry, and surface chemical spot structure for this star. We derived a precise photometric rotational period of 1.71650213(21) d based on 1 yr of TESS nearly continuous space observations and discovered modulation of the stellar light curve with the phase of the 127.9-d binary orbit due to the light time travel effect. We revised parameters of the binary orbit and detected spectroscopic contribution of the secondary. A tomographic mapping technique was applied to the average intensity and circular polarization profiles derived from Narval high-resolution spectropolarimetric observations. This analysis yielded a detailed map of the global magnetic field topology together with the surface distributions of Si, Cr, and Fe abundances. Magnetic mapping demonstrates that the surface field structure of φ Dra is dominated by a distorted dipolar component with a peak field strength of 1.4 kG and a large asymmetry between the poles. Chemical maps show an enhancement of Cr, Fe and, to a lesser extent, Si in a series of spots encircling intersections of the magnetic and rotational equators. These chemical spot geometries do not directly correlate with either the local field strength or the field inclination.
Improved galactic foreground removal for B-mode detection with clustering methods
Authors: Puglisi Giuseppe , Mihaylov Gueorgui , Panopoulou Georgia V , Poletti Davide , Errard Josquin , Puglisi Paola A , Vianello Giacomo 
Published: January 2022

ABSTRACT
Characterizing the sub-mm Galactic emission has become increasingly critical especially in identifying and removing its polarized contribution from the one emitted by the cosmic microwave background (CMB). In this work, we present a parametric foreground removal performed on to sub-patches identified in the celestial sphere by means of spectral clustering. Our approach takes into account efficiently both the geometrical affinity and the similarity induced by the measurements and the accompanying errors. The optimal partition is then used to parametrically separate the Galactic emission encoding thermal dust and synchrotron from the CMB one applied on two nominal observations of forthcoming experiments from the ground and from the space. Moreover, the clustering is performed on tracers that are different from the data used for component separation, e.g. the spectral index maps of dust and synchrotron. Performing the parametric fit singularly on each of the clustering derived regions results in an overall improvement: both controlling the bias and the uncertainties in the CMB B-mode recovered maps. We finally apply this technique using the map of the number of clouds along the line of sight, $\mathcal {N}_c$, as estimated from H i emission data and perform parametric fitting on to patches derived by clustering on this map. We show that adopting the $\mathcal {N}_c$ map as a tracer for the patches related to the thermal dust emission, results in reducing the B-mode residuals post-component separation. The code is made publicly available https://github.com/giuspugl/fgcluster.
A complex network of interactions governs DNA methylation at telomeric regions
Authors: Farrell Colin , Vaquero-Sedas María I , Cubiles María D , Thompson Michael , Vega-Vaquero Alejandro , Pellegrini Matteo , Vega-Palas Miguel A 
Published: January 2022

Abstract
DNA methylation modulates telomere function. In Arabidopsis thaliana, telomeric regions have a bimodal chromatin organization with unmethylated telomeres and methylated subtelomeres. To gain insight into this organization we have generated TAIR10-Tel, a modified version of the Arabidopsis reference genome with additional sequences at most chromosome ends. TAIR10-Tel has allowed us to analyse DNA methylation at nucleotide resolution level in telomeric regions. We have analysed the wild-type strain and mutants that encode inactive versions of all currently known relevant methyltransferases involved in cytosine methylation. These analyses have revealed that subtelomeric DNA methylation extends 1 to 2 kbp from Interstitial Telomeric Sequences (ITSs) that abut or are very near to telomeres. However, DNA methylation drops at the telomeric side of the telomere-subtelomere boundaries and disappears at the inner part of telomeres. We present a comprehensive and integrative model for subtelomeric DNA methylation that should help to decipher the mechanisms that govern the epigenetic regulation of telomeres. This model involves a complex network of interactions between methyltransferases and subtelomeric DNA sequences.
Dicer dependent tRNA derived small RNAs promote nascent RNA silencing
Authors: Di Fazio Arianna , Schlackow Margarita , Pong Sheng Kai , Alagia Adele , Gullerova Monika 
Published: January 2022

Abstract
In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves the cleavage of target messenger RNA (mRNA) or inhibition of translation in the cytoplasm, and transcriptional gene silencing (TGS), which is mediated by the establishment of repressive epigenetic marks at target loci. Transfer RNAs (tRNAs), which are essential for translation, can be processed into small ncRNAs, termed tRNA-derived small RNAs (tsRNAs). The biogenesis of tsRNAs and their role in gene expression regulation has not yet been fully understood. Here, we show that Dicer dependent tsRNAs promote gene silencing through a mechanism distinct from PTGS and TGS. tsRNAs can lead to downregulation of target genes by targeting introns via nascent RNA silencing (NRS) in nuclei. Furthermore, we show that Ago2 slicer activity is required for this mechanism. Synthetic tsRNAs can significantly reduce expression of a target gene at both RNA and protein levels. Target genes regulated by NRS are associated with various diseases, which further underpins its biological significance. Finally, we show that NRS is evolutionarily conserved and has the potential to be explored as a novel synthetic sRNA based therapeutic.
Lifelong effect of therapy in young patients with the COL4A5 Alport missense variant p.(Gly624Asp): a prospective cohort study
Authors: Boeckhaus Jan , Hoefele Julia , Riedhammer Korbinian M , Nagel Mato , Beck Bodo B , Choi Mira , Gollasch Maik , Bergmann Carsten , Sonntag Joseph E , Troesch Victoria , Stock Johanna , Gross Oliver 
Published: January 2022

ABSTRACT

Background
Angiotensin-converting enzyme inhibitors (ACEis) have evolved as a first-line therapy for delaying end-stage renal failure (ESRF) in Alport syndrome (AS). The present study tested the hypothesis of a superior nephroprotective potential of an early ACEi intervention, examining a cohort with the COL4A5 missense variant p.(Gly624Asp).

Methods
In this observational cohort study (NCT02378805), 114 individuals with the identical gene variant were explored for age at ESRF and life expectancy in correlation with treatment as endpoints.

Results
All 13 untreated hemizygous patients developed ESRF (mean age 48.9 ± 13.7 years), as did 3 very late treated hemizygotes (51.7 ± 4.2 years), with a mean life expectancy of 59.2 ± 9.6 years. All 28 earlier-treated [estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2] hemizygous patients were still alive and still had not reached ESRF. Therapy minimized the annual loss of their GFR, similar to the annual loss in healthy individuals. Of 65 heterozygotes, 4 untreated individuals developed ESRF at an age of 53.3 ± 20.7 years. None of the treated heterozygous females developed ESRF.

Conclusions
For the first time, this study shows that in AS, early therapy in individuals with missense variants might have the potential to delay renal failure for their lifetime and thus to improve life expectancy and quality of life without the need for renal replacement therapy. Some treated patients have reached their retirement age with still-functioning kidneys, whereas their untreated relatives have reached ESRF at the same or a younger age. Thus, in children with glomerular haematuria, early testing for Alport-related gene variants could lead to timely nephroprotective intervention.
Use of 18F-fluorodeoxyglucose positron emission tomography to standardize clinical trial recruitment in Takayasu’s arteritis
Authors: Quinn Kaitlin A , Alessi Hugh D , Ponte Cristina , Rose Emily , Ahlman Mark A , Redmond Christopher , Luo Yiming , Bolek Ertugrul Cagri , Langford Carol A , Merkel Peter A , Grayson Peter C 
Published: January 2022

AbstractObjectivesTo assess whether data from 18F-fluorodeoxyglucose (FDG) PET should be incorporated into eligibility criteria for clinical trials in Takayasu’s arteritis (TAK).MethodsThe study was conducted in two parts. Part one was an international online survey among physicians with experience managing TAK to determine, using clinical vignettes, whether FDG-PET data influence decisions about enrolment in trials. Part two used patient data from an observational cohort study in TAK to assess agreement regarding decisions about enrolment into trials, based on clinical assessment with and without incorporation of FDG-PET data.ResultsIn part one, 68 physicians responded to the survey. Most physicians had used FDG-PET to diagnose TAK (82%) or monitor disease activity (66%). In vignettes representing active clinical disease, FDG-PET findings increased physician confidence in disease assessment and reduced outlier assessments. The greatest variability in decisions regarding enrolment into trials was observed in vignettes representing constitutional symptoms alone and elevated acute-phase reactants. In these cases, FDG-PET findings influenced decisions about enrolment and improved physician confidence. In multivariable models, FDG-PET findings were 1.29 times more strongly associated with enrolment decisions compared with levels of acute-phase reactants. In part two, incorporation of FDG-PET data significantly improved agreement about enrolment decisions between raters [inter-rater reliability (IRR) = 0.68 (95% CI 0.67, 0.69) to IRR = 0.88 (95% CI 0.87, 0.89); P &lt; 0.01].ConclusionsIncorporation of FDG-PET data into assessment of TAK influences decisions about enrolment of patients into trials, improves physician confidence about clinical assessment and could help reduce variability in study populations. Future trials in TAK should consider incorporating FDG-PET data into eligibility criteria.
Interaction between the proprietary base theory and subrogation—‘It WAS mine’, ‘It HAD BEEN mine’, but IS it yours?
Authors: Chong Conrad 
Published: January 2022

Abstract
The law of restitution has developed rapidly in recent decades. Many concepts have been created, refined, and diminished. The proprietary base theory is one of the concepts that is increasingly marginalized. This article examines this theory and advocates its rejuvenation. By analysing the decision Menelaou v Bank of Cyprus UK Ltd, the interaction between the proprietary base theory and the principle of equitable subrogation is dissected. This article concludes that the proprietary base theory can clarify uncertainties in subrogation cases involving proprietary claims and remains an important tool in relevant litigations.
Early Experience Using a New Robotic Microsurgical System for Lymphatic Surgery
Authors: Lindenblatt Nicole , Grünherz Lisanne , Wang Anna , Gousopoulos Epameinondas , Barbon Carlotta , Uyulmaz Semra , Giovanoli Pietro 
Published: January 2022

Summary:
Robotic microsurgery has emerged as a new technology with potential benefits for reconstructive surgery. We report the first-in-human use of the Symani surgical system to perform lympho-venous and arterial anastomosis for lymphatic reconstruction. In five patients, 10 robot-assisted anastomoses were performed. Next to lympho-venous anastomoses, two patients received a free vascularized lymph node transfer. Motion scaling was set to 10×. Visualization was either achieved with a 3D system or an optical microscope. All anastomoses were patent as confirmed by ICG. Despite a longer time to perform the first anastomoses with the robot, we observed a decline in duration of anastomosis. Among the advantages of the system were a high accuracy in placing the stitches even in very small and fragile vessels or when performing anastomoses with size mismatches. The challenges encountered included the lack of a touch sensation and the necessity to develop a “see-feel.” This could be achieved surprisingly well because the force necessary to close dilator and needle holder via the manipulators was perceived as comparable to using conventional micro instruments. Our data confirm feasibility and safety of the robotic system to perform lymphatic surgery. Larger patient cohorts and inclusion of surgeons at different training levels will be necessary to investigate the true potential of robotics in microsurgery. In addition, robot-assisted surgery shows a promising potential in opening up new frontiers in reconstructive microsurgery (eg, the reliable performance of anastomoses on even smaller blood and lymphatic vessels or on structures deeper within the body cavities—eg, the thoracic duct).
Hospitalized Children With Common Human Coronavirus Clinical Impact of Codetected Respiratory Syncytial Virus and Rhinovirus
Authors: Heimdal Inger , Valand Jonas , Krokstad Sidsel , Moe Nina , Christensen Andreas , Risnes Kari , Nordbø Svein Arne , Døllner Henrik 
Published: January 2022

Background:
The clinical impact of common human coronavirus (cHCoV) remains unclear. We studied the clinical manifestations of pediatric cHCoV infections and the possible modifying effects of codetected human rhinovirus (RV) and respiratory syncytial virus (RSV).

Methods:
We used data from an 11-year-long prospective study of hospitalized children with community-acquired respiratory tract infections. Nasopharyngeal aspirates were analyzed with real-time polymerase chain reaction assay for cHCoV OC43, NL63, HKU1 and 229E, and 15 other respiratory viruses. We assessed disease severity based on the clinical factors hospitalization length, oxygen requirement, other respiratory support and supplementary fluids.

Results:
cHCoV was detected in 341 (8%) of 4312 children. Among 104 children with single cHCoV detections, 58 (56%) had lower respiratory tract infection (LRTI) and 20 (19%) developed severe disease. The proportion with severe disease was lower among single cHCoV detections compared with single RSV detections (338 of 870; 39%), but similar to single RV detections (136 of 987; 14%). Compared with single cHCoV, codetected cHCoV-RSV was more often associated with LRTI (86 of 89; 97%) and severe disease (adjusted odds ratio, 3.3; 95% confidence interval: 1.6–6.7). LRTI was more frequent in codetected cHCoV-RV (52 of 68; 76%) than single cHCoV, but the risk of severe disease was lower (adjusted odds ratios, 0.3; 95% confidence interval: 0.1–1.0).

Conclusions:
cHCoV was associated with severe LRTI in hospitalized children. Viral codetections were present in two-thirds. Codetections of cHCoV-RV were associated with lower proportions of severe disease, suggesting a modifying effect of RV on HCoV.
Variation in Patient-Reported Outcomes in Young and Old Patients Up to 4 to 6 Years After Arthroscopic Partial Meniscectomy
Authors: Tayfur Beyza , Pihl Kenneth , Varnum Claus , Lohmander Stefan , Englund Martin , Thorlund Jonas Bloch 
Published: January 2022

Objective:
To assess the variation in changes in patient-reported outcomes 4 to 6 years after arthroscopic partial meniscectomy (APM).

Design:
Prospective cohort study.

Setting:
Orthopedic departments at public hospitals.

Patients:
Patients (n = 447) from the Knee Arthroscopy Cohort Southern Denmark undergoing APM.

Interventions:
All patients underwent APM.

Main Outcome Measures:
Change in KOOS4 scores from baseline before surgery to ∼5 years (range 4-6 years) after surgery. KOOS4 is the average aggregated score of 4 of 5 of the Knee injury and Osteoarthritis Outcome Score (KOOS) excluding the activities of daily living subscale (minimal clinical important improvement ∼10 points). A mixed linear model adjusted for sex and body mass index was used to assess change from baseline to ∼5-year follow-up. Change in KOOS4 was divided into 5 categories based on change from baseline to ∼5-year follow-up: <0 points, 0 to 9 points, 10 to 19 points, 20 to 29 points, and ≥30 points.

Results:
On average, patient-reported outcomes continued to improve from baseline to ∼5-year follow-up (mean KOOS4 change: 26, 95% CI, 24-28). Proportions in the different response groups were <0 points (12%), 0 to 9 points (13%), 10 to 19 points (16%), 20 to 29 points (19%), and ≥30 points (40%), with no difference between younger (≤40 years, n = 75) and older (>40 years, n = 337) patients (P = 0.898).

Conclusions:
Patient-reported outcomes on average improved up to ∼5 years after APM; however, large variability was observed. The similar variability in younger and older patients questions the assumption that younger patients with traumatic injuries experience larger benefits from APM.