bluuebunny/crossref_metadata_2025_split huggingface dataset:
Candidate Chemosensory Genes Identified in the Adult Antennae of Sympiezomias velatus and Binding Property of Odorant-Binding Protein 15
Authors: Li Xiao , Li Jian-Wen , Sun Wen-Xiu , Li Wei , Gao Hua-Yuan , Liu Tong-Xian , Qu Ming-Jing 
Published: May 2022

Chemosensory genes play important roles in insect behaviors and have thus become potential molecular targets for pest control based on the manipulation of chemoreception-driven behaviors. The great gray weevil Sympiezomias velatus (Chevrolat) (Coleoptera: Curculionidae) is an important agricultural pest that causes serious economic losses to many crops in China, but its chemosensory genes have not been reported. Here we assembled the antennal transcriptomes of female and male adult S. velatus and revealed the major chemosensory genes necessary for olfaction. A total of 138 candidate chemosensory genes in six families were identified, including 41 encoding odorant-binding proteins (OBPs), 11 encoding chemosensory proteins (CSPs), 62 encoding odorant receptors (ORs), 15 encoding gustatory receptors (GRs), six encoding ionotropic receptors (IRs), and three encoding sensory neuron membrane proteins (SNMPs). We analyzed their phylogenetic relationship based on the amino acid sequences of these chemosensory-related protein families in S. velatus and other insects, and the expression profiles based on their antennal transcriptomes. Chemosensory genes that show antenna-abundant/specific or sex-biased expression were observed, suggesting that these genes might have functions in olfaction. Furthermore, we chose an antenna-abundant OBP belonging to ABPX subfamily, SvelOBP15, to investigate its binding property. The results showed that among 33 tested compounds, SvelOBP15 displayed high binding affinities (Ki = 7.36–12.94 μmol/L) with farnesol, nerolidol, limonene and diisobutyl phthalate, indicating that SvelOBP15 plays olfactory roles by binding and transporting specific plant volatiles. These findings will help us better understand the olfactory systems of S. velatus, and provide a basis for functional elucidation of these chemosensory genes.
Effect of DL-Methylephedrine on Dopamine Transporter Using Positron Emission Tomography With [18F]FE-PE2I
Authors: Nogami Tsuyoshi , Arakawa Ryosuke , Sakayori Takeshi , Ikeda Yumiko , Okubo Yoshiro , Tateno Amane 
Published: May 2022

RationaleSince ephedrine has a dopamine transporter (DAT) inhibitory effect similar to amphetamine, dl-methylephedrine, a derivative of ephedrine, is considered to have the characteristics of a central nervous system stimulant due to the DAT inhibitory effect. For example, the World Anti-Doping Agency categorizes dl-methylephedrine as a stimulant in the prohibited list for competitions. Assuming to have the same effect as ephedrine, the urinary concentration of dl-methylephedrine is regulated below 10 μg/mL, as is ephedrine. However, the extent to which dl-methylephedrine affects brain function is not yet fully understood.ObjectivesThe purpose of this study was to evaluate DAT occupancy by a single oral administration of a daily dose of dl-methylephedrine using positron emission tomography (PET) with [18F]FE-PE2I to characterize its stimulatory effect on the central nervous system.MethodsNine healthy male volunteers were enrolled in the study. The experiments were designed as a placebo-controlled randomized double-blind crossover comparative study. After the first PET scan in a drug-free state, the second and third PET scans were performed with randomized dosing at 60 mg of dl-methylephedrine or placebo. The plasma and urine concentrations of dl-methylephedrine were measured just before and after the PET scans, respectively.ResultsMean urine and plasma concentrations of dl-methylephedrine were 13.9 μg/mL and 215.2 ng/mL, respectively. Mean DAT occupancy in the caudate was 4.4% for dl-methylephedrine and 1.2% for placebo. Mean DAT occupancy in the putamen was 3.6% for dl-methylephedrine and 0.5% for placebo. There was no significant difference of DAT occupancies between the groups.ConclusionIn this study, the urinary concentration of dl-methylephedrine (13.9 μg/mL) was higher than the prohibited reference value (10.0 μg/mL), and there was no significant difference in DAT occupancy between dl-methylephedrine and placebo. These findings suggest that a clinical daily dose of dl-methylephedrine may exceed the doping regulation value according to urine concentration; however, it was considered that at least the central excitatory effect mediated by DAT inhibition was not observed at the daily dose of dl-methylephedrine.
Predictive Nomogram for Clinical Prognosis in Cervical Spondylotic Myelopathy With Intramedullary T2-Weighted Increased Signal Intensity: A Novel Digital Tool for Patient Prognosis Education
Authors: Wang Jie , Li Haopeng , Yang Baohui 
Published: May 2022

AimsTo establish a predictive nomogram for clinical prognosis in cervical spondylotic myelopathy (CSM) with intramedullary T2-weighted increased signal intensity (ISI).MethodsThe clinical data of 680 patients with CSM with intramedullary T2-weighted ISI were retrospectively analyzed. The patients were divided into the modeling group (476) and the validation group (204) by using a random number table at a ratio of 7:3. The independent prognostic factors were screened using multivariate logistic regression analysis. The factors were subsequently incorporated into the establishment of the predictive nomogram. The area under the receiver operating characteristic (ROC) curve (AUC) was undertaken to estimate the discrimination of the predictive nomogram. The calibration curve and the Hosmer-Lemeshow test were used to assess the calibration of the predictive nomogram. The clinical usefulness of the predictive nomogram was evaluated by decision curve analysis (DCA).ResultsBased on the pre-operative Japanese Orthopedic Association (JOA) score, maximal canal compromise (MCC), and maximal spinal cord compression (MSCC), we established a predictive nomogram. The AUCs in the modeling group and validation group were 0.892 (95% CI: 0.861~0.924) and 0.885 (95% CI: 0.835~0.936), respectively, suggesting good discrimination of the nomogram. Calibration curves showed a favorable consistency between the predicted probability and the actual probability. In addition, the values of P of the Hosmer-Lemeshow were 0.253 and 0.184, respectively, suggesting good calibration of the nomogram. DCA demonstrated that the nomogram had good clinical usefulness.ConclusionWe established and validated a predictive nomogram for the clinical prognosis in CSM with intramedullary T2-weighted ISI. This predictive nomogram could help clinicians and patients identify high-risk patients and educate them about prognosis, thereby improving the prognosis of high-risk patients.
Continuous Endogenous Exhaled CO Monitoring by Laser Spectrometer in Human EVLP Before Lung Transplantation
Authors: Brenckmann Vivien , Briot Raphael , Ventrillard Irène , Romanini Daniele , Barbado Maud , Jaulin Kevin , Trocme Candice , De Wolf Julien , Glorion Matthieu , Sage Édouard 
Published: May 2022

Endogenous production of carbon monoxide (CO) is affected by inflammatory phenomena and ischemia-reperfusion injury. Precise measurement of exhaled endogenous CO (eCO) is possible thanks to a laser spectrometer (ProCeas® from AP2E company). We assessed eCO levels of human lung grafts during the normothermic Ex-Vivo Lung Perfusion (EVLP). ProCeas® was connected in bypass to the ventilation circuit. The surgical team took the decision to transplant the lungs without knowing eCO values. We compared eCO between accepted and rejected grafts. EVLP parameters and recipient outcomes were also compared with eCO values. Over 7 months, eCO was analyzed in 21 consecutive EVLP grafts. Two pairs of lungs were rejected by the surgical team. In these two cases, there was a tendency for higher eCO values (0.358 ± 0.52 ppm) compared to transplanted lungs (0.240 ± 0.76 ppm). During the EVLP procedure, eCO was correlated with glucose consumption and lactate production. However, there was no association of eCO neither with edema formation nor with the PO2/FiO2 ratio per EVLP. Regarding post-operative data, every patient transplanted with grafts exhaling high eCO levels (&gt;0.235 ppm) during EVLP presented a Primary Graft Dysfunction score of 3 within the 72 h post-transplantation. There was also a tendency for a longer stay in ICU for recipients with grafts exhaling high eCO levels during EVLP. eCO can be continuously monitored during EVLP. It could serve as an additional and early marker in the evaluation of the lung grafts providing relevant information for post-operative resuscitation care.
Effect-Directed Profiling of Monofloral Honeys from Ethiopia by High-Performance Thin-Layer Chromatography and High-Resolution Mass Spectrometry
Authors: Morlock Gertrud E. , Belay Abera , Heil Julia , Mehl Annabel , Borck Hannelore 
Published: May 2022

Ethiopian honey is used not only as food but also for treatment in traditional medicine. For its valorization, bioactive compounds were analyzed in nine types of monofloral Ethiopian honey. Therefore, a non-target effect-directed profiling was developed via high-performance thin-layer chromatography combined with multi-imaging and planar effect-directed assays. Characteristic bioactivity profiles of the different honeys were determined in terms of antibacterial, free-radical scavenging, and various enzyme inhibitory activities. Honeys from Hypoestes spp. and Leucas abyssinica showed low activity in all assays. In contrast, others from Acacia spp., Becium grandiflorum, Croton macrostachyus, Eucalyptus globulus, Schefflera abyssinica, Vernonia amygdalina, and Coffea arabica showed more intense activity profiles, but these differed depending on the assay. In particular, the radical scavenging activity of Croton macrostachyus and Coffea arabica honeys, the acetylcholinesterase-inhibiting activity of Eucalyptus globulus and Coffea arabica honeys, and the antibacterial activity of Schefflera abyssinica honey are highlighted. Bioactive compounds of interest were further characterized by high-resolution mass spectrometry. Identifying differences in bioactivity between mono-floral honey types affects quality designation and branding. Effect-directed profiling provides new insights that are valuable for food science and nutrition as well as for the market, and contributes to honey differentiation, categorization, and authentication.
Experiences and behaviours of patients with asthma requesting prescriptions from primary care during medication shortages linked to the COVID-19 lockdown: insights from a qualitative analysis of a UK asthma online community
Authors: Ow Nadya L , Sadek Attalla Sara , Davies Gwyneth , Griffiths Chris J , De Simoni Anna 
Published: May 2022

BackgroundInhaler shortages were reported in the UK following declaration of the COVID-19 pandemic, prompting advice against stockpiling.AimTo understand experiences and behaviours of patients with asthma requesting prescriptions from primary care during asthma medication shortages.Design & settingUK asthma online community, between March and December 2020.MethodThematic analysis of posts identified using search terms ‘shortage’, ‘out of stock’, ‘prescribe’, and ‘prescription’.ResultsSixty-seven participants were identified (48 adults, two children, 17 unstated age). Factors leading to increased requests included the following: stockpiling; early ordering; realising inhalers were out of date; and doctors prescribing multiple medication items. Patients’ anxieties that could lead to stockpiling included the following: fear of asthma attacks leading to admission and acquiring COVID-19 in hospital; lack of dose counters on some inhalers; and believing a lower amount of drug is delivered in the last actuations. Strategies adopted in relation to shortages or changes in treatment owing to out-of-stock medications included the following: starting stockpiling; ordering prescriptions early; contacting medical professionals for advice or alternative prescriptions; getting ‘emergency prescriptions’; ordering online or privately; seeking medications in different pharmacies; contacting drug manufacturers; and keeping track of number of doses left in canisters. No evidence was found of anxiety-triggered asthma symptoms that required medications due to fear of COVID-19. Participants seemed to disregard advice against stockpiling.ConclusionBetter preparation is a key lesson from the COVID-19 pandemic. Clinicians, the pharmaceutical industry, and policymakers should use insights from this work to plan how to better manage medication shortages in future emergency situations.
Features Selection of Phlebosurgery Tactics Depending on the Degree of Injury if Craniofacial Gunshot Wound
Authors: Азизов Р.Ф. 
Published: May 2022

Цель исследования. Изучение особенностей выбора хирургической тактики в зависимости от степени повреждения при черепно-лицевом огнестрельном ранении (травма, вызванная столкновением пули с инородным телом (оптический бинокль)).Материалы и методы. Представлена хирургическая тактика на примере мужчины – военного офицера, который получил огнестрельное ранение. Операции, проведенные авторами, и исследования показали, что даже при самых тяжелых огнестрельных ранениях краниомаксилло-лицевое качество скорой помощи и правильный выбор хирургической тактики показывают высокий клинический эффект.
The purpose of the study. To investigate the features of the choice of surgical tactics depending on the degree of injury if craniofacial gunshot wound (trauma caused by the collision of a bullet from a foreign body (optical binoculars)).The material of the study was a male military officer, received a gunshot wound craniofacial area. Operations conducted by the authors and their research has shown that even under the most severe gunshot wounds craniofacial quality ambulance and the right choice of surgical tactics shows high clinical effect.
Dampak Sosialisasi Perpajakan, Pemahaman Wajib Pajak, Tarif Pajak, Sanksi Pajak dan Kualitas Pelayanan Fiskus terhadap Kepatuhan Wajib Pajak
Authors: Saputra Deni , Dewi Rindy Citra , Afriani Vivi 
Published: May 2022

Penelitian ini bertujuan untuk menguji “Dampak sosialisasi perpajakan, pemahaman wajib pajak, tarif pajak, sanksi pajak dan kualitas pelayanan fiskus terhadap kepatuhan wajib pajak”. Dengan mengambil data dengan cara menyebarkan kuisioner terhadap 82 sampel pada kantor UMKM kota padang. Analisis data dalam penelitian ini menggunakan analisis regresi linear berganda. Alat analisis yang digunakan adalah SPSS versi 22 .Hasil penelitian ini menyimpulkan bahwa : (1) Sosialisasi perpajakan tidak berpenagruh signifikan terhadap kepatuhan wajib pajak (2) Pemahaman wajib pajak berpengaruh signifikan terhadap kepatuhan wajib pajak (3) Tarif pajak tidak berpenagruh signifikan terhadap kepatuhan wajib pajak (4) Sanksi pajak tidak berpenagruh signifikan terhadap kepatuhan wajib pajak (5) Kualitas pelayanan fiskus berpengaruh signifikan terhadap kepatuhan wajib pajak.
PERLINDUNGAN HUKUM TERHADAP PELAKU TINDAK PIDANA MEMBERIKAN HAK PILIH LEBIH SATU KALI PILKADA 2017 DI KABUPATEN ACEH BARAT
Authors: Yunus Muhammad , Ath Thariq Phoenna , Trisna Nila , Nasir Muhammad 
Published: May 2022

Every Indonesian citizen actually has the same rights before the law. Likewise, the perpetrators of criminal acts get treatment in accordance with the capacity of the acts committed. Legal protection does not really focus on welfare, but rather on the determination of the consequences of a legal event. This is outlined in the 1945 Constitution Article 27 Paragraph 1. Responding to the paradigm of thinking about the perpetrators of criminal offenses should get the maximum punishment, it does not mean to impose a sentence that exceeds the legal capacity in force in the country. this also applies to the double cast in the 2017 regional elections which took place in the District of West Aceh. The mechanism of the process of legal protection for perpetrators of criminal acts, is part of legal efforts in ensuring justice with legal certainty for the benefit of the law through formal and or material stages. Law Number 16 of 2011 concerning Legal Aid and Law Number 39 of 1999 concerning Human Rights is a form of the state's seriousness in guaranteeing the constitutional rights of each of its citizens to obtain recognition, guarantees, protection and fair legal certainty and equal treatment. before the law. Keywords: Protection, Law, West Aceh
Utilization Of Mangrove Forest As Alternative Income For Coastal Communities In Sukakerta Village, Karawang
Authors: Ali Fikri Mohammad Rom , Sam'un Mohamad , Lestari Zeni Ayu , Rahmawati Tasyah Dwi , Triadi Triadi 
Published: May 2022

The existence of mangrove forests are ecologically important because it supports the food chain in the area by protecting the coast from strong winds, abrasion/erosion, and tsunamis. Besides the ecological benefits, mangroves are also economically beneficial. The economic function is as a producer of wood for raw materials, building materials, and food. Besides that, the biota that lives in the mangrove ecosystem also has economic value if processed properly. This service activity was carried out in the Tengkolak hamlet, Sukakerta Village, Cilamaya Wetan District, Karawang Regency, which is not very familiar with the use of mangrove fruit and natural products so that it has high economic value and improves community welfare. Through KUB, the activity aims to improve the understanding and skills of the community on how to process mangrove fruit and biota in the ecosystem into various products as an alternative for additional income. The people who take part in this activity are people who are members of the KUB Kreasi Alam Bahari. The method of carrying out the activities is through demonstrations and training on making coffee from mangrove trees and the Talang-talang fish product variant, which has been developed into skin chips, nuggets, and fish balls. The evaluation process was carried out by interviewing several residents to ask for information and impressions of the activities that had been carried out. The community, especially those who participated in the activity, felt the positive impact of these activities. Because they can increase their skills in processing mangrove fruit and processing Talang-talang fish that have higher economic value.
PENGARUH BAURAN PEMASARAN 4P (PRODUK, PRICE, PLACE, PROMOTION) DAN KUALITAS PELAYANAN BERBASIS SYARIAH TERHADAP KEPUTUSAN KONSUMEN UNTUK MEMBELI DI TOKO YUNIKA JABON SIDOARJO
Authors: Mundir Abdillah , Rahayu Anita Agustining 
Published: May 2022

Marketing means everything that producers can offer to be noticed, requested, sought, bought, used or consumed by the market as a fulfillment of the needs or desires of the relevant market, while sharia marketing is a business strategy that must cover all activities within a company, covering the entire process, creating , offering, exchange of value, services, from a producer, or a company or individual, in accordance with Islamic teachings. The approach used by researchers in this study is a quantitative approach with multiple linear regression, t test, and f test using data collection techniques through questionnaires. Meanwhile, the instrument used in this research is the Likert scale. Based on the results of the research and the results of the regression analysis that has been carried out, the following conclusions can be drawn: 1) The marketing mix has a significant effect on consumer buying decisions at Yunika Stores. This is indicated by the value of thecalculated is greater than the Ttable (7.272 > 2.00665). 2) The quality of sharia-based service has a significant effect on consumer decisions to buy at Yunika Stores. This is indicated by the Tcount is greater than the Ttable (6.020 > 2.00665). 3) Marketing mix and service quality have a joint effect on consumer buying decisions at Yunika Stores with Fcount greater than Ftable (27.828 > 3.17).
KEJADIAN CEDERA MUSKULOSKELETAL SAAT MELAKUKAN EXERCISE SELAMA MASA PANDEMI COVID-19
Authors: Pristianto Arif , Mutia Andini Rizqi , Faris Naufal Adnan 
Published: May 2022

Penetapan COVID-19 sebagai pandemi global oleh World Health Organization menyebabkan perubahan gaya hidup dan perilaku. Exercise diperlukan untuk mempertahankan status kesehatan serta mengatasi konsekuensi negatif dari penyakit tertentu. Aktivitas yang berlebihan saat melakukan exercise, pengulangan terus-menerus, dan gerakan yang kurang tepat dapat menyebabkan cedera muskuloskeletal. Tujuan dari penelitian ini untuk mengetahui kejadian dan menganalisis area cedera muskuloskeletal saat melakukan exercise selama masa Pandemi COVID-19. Penelitian ini termasuk jenis observasional pendekatan cross sectional dengan jumlah sampel penelitian sebanyak 107 orang. Pelaksanaan dilakukan pada bulan November-Desember 2020, dengan pengisian kuesioner yang disebarkan melalui media sosial. Berdasarkan uji statistika didapatkan adanya hubungan cedera muskuloskeletal saat melakukan exercise selama masa Pandemi COVID19, dengan p < 0,05. Uji Spearman Correlation menunjukkan nilai p = 0,000 atau p < 0,05. Hasil menunjukkan korelasi positif pada cedera muskuloskeletal saat melakukan exercise selama masa Pandemi COVID-19. Terdapat hubungan cedera muskuloskeletal saat melakukan exercise selama masa Pandemi COVID-19. Jenis cedera muskuloskeletal dialami responden terbanyak yaitu strain dan pada area kaki/tungkai
Educación y sostenibilidad
Authors: Arboleda Julio César 
Published: May 2022

El primer artículo del presente número de la Revista Boletín Redipe pone de manifiesto la tensión, que cada vez sacude a la existencia, entre el mundo del consumo y el mundo de la vida; la erosión de este último por aquel. La cultura del consumo que hoy gravita como nunca jamás en las relaciones entre los seres humanos y de estos con la naturaleza, es agenciada por fuerzas que encuentran en ésta una manera de maximizar ganancias, productividades y rentabilidades que no se traducen en bienestar para todos, en igualdad de derechos y oportunidades, en cuidado del planeta, sino por el contrario en minimización inexorable del acceso de todos a los bienes más elementales que se requieren para vivir con dignidad, se traduce en amenaza inminente para el futuro de la humanidad y de la vida, en posibilidad real de autoextinción. El orden del consumo impone la creencia de que el mundo del mercado constituye el motor del mundo de la vida. Como lo hemos expresado en otros momentos: el mundo del mercado no es el mundo de la vida.
Es este un desafío insalvable para la educación, que le impone redireccionar su curso, su apuesta por generar escenarios para que el hombre, en lugar de aposentarse en la cima del planeta, del mundo de la vida, desarrolle una consciencia reflexiva y actuante hacia la vida, hacia el tejido de naturaleza y vida, de mundo común. Para decirlo con Mínguez, R. (2022), “es preciso reorientar el sentido de la educación hacia una forma de vida sostenible”, en el marco de una ética y una práctica otras, de una ética y actividad educativa por los negocios, a una ética y educación por la vida. Una educación que haga de la actividad de enseñar, aprender y formar una posibilidad de pensar sintiendo, para decirlo con Rodríguez; M. E, (2022 ), en el contexto de la matemática, “el sentipensar como forma matemática de expresarse a la luz de la emotividad del estudiante”, o con Lopera, C.P, (2022), “la necesidad de tener maestros y maestras alegres y empáticos, sobrepasando la mirada adultocéntrica que ha primado en las relaciones pedagógicas y sociales”. El sentido más entrañable de la educación precisa una ética del buen vivir y del vivir sabroso, con sentido de mundo común, en lugar de la ética de los negocios, del vivir bien particular con sentido fragmentario que hoy domina en la escolaridad y en la vida cotidiana.