bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation of Effectiveness of a Texture Feature Based Computerized
Diagnostic Model in Classifying the Ovarian Cyst as Benign and Malignant
from Static 2D B-Mode Ultrasound Images
Authors: Sheela S. , Sumathi Manickam 
Published: May 2022

Objective:
To develop a computerized diagnostic model to characterize the ovarian cyst at
its early stage in order to avoid unnecessary biopsy and patient anxiety.

Background:
The main cause of mortality and infertility in women is ovarian cancer. It is very difficult
to diagnose ovarian cancer using ultrasonography as benign and malignant ovarian masses or cysts
exhibit similar characteristics. Early prediction and characterization of ovarian masses will reduce the
unwanted growth of the ovarian mass.

Materials and Methods:
Transvaginal 2D B mode ovarian mass ultrasound images were preprocessed
initially to enhance the image quality. And then, the region of interest (ROI) in this case ovarian cyst
was segmented. Finally, Local Binary Pattern (LBP) textural features were extracted. A Support Vector
Machine was trained to classify the ovarian cyst or mass as benign or malignant.

Results:
The performance of the SVM improved with an average accuracy of 92% when the textural
features were extracted from the Original Gray Value-based LBP (OGV-LBP) image than the histogram-
based LBP.

Conclusion:
The SVM can classify the transvaginal 2D B mode ovarian cyst ultrasound images into
benign and malignant effectively when the textural features from the original gray value-based LBP
extracted were considered.
Reduced-Dose Full-Body CT in Lymphoma Follow-up: A Pilot Study
Authors: Zhang Ling , Li Caixia , Li Yonggang , Huang Renjun , Yan Jiulong , Geng Hongzhi , Yu Qiuyu , Sun Zongqiong , Liu Wenyan 
Published: May 2022

Background:
How to reduce the radiation dose received from full-body CT scans during the
follow-up of lymphoma patients is a concern.

Objective:
The aim of the study was to investigate the image quality and radiation dose of reduced-dose
full-body computerized tomography (CT) in lymphoma patients during the follow-up.

Methods:
121 patients were included and divided into conventional CT group (group 1, 120-kVp, n =
61) or reduced-dose CT group (group 2, 100-kVp combined dual-energy CT (DECT), n = 60). 140-kVp
polychromatic images and 70-keV monochromatic images were reconstructed from DECT. The abdominal
virtual non-enhanced (VNE) images were reconstructed from monochromatic images. Two
radiologists rated the overall image quality with a five-point scale and graded the depiction of lesions
using a four-point scale. The objective image quality was evaluated using image noise, signal-to-noise
ratio, and contrast-to-noise ratio. The radiation dose and image quality were compared between the
groups.

Results:
The comparable subjective image quality was observed between 70-keV and 120-kVp images
in the neck, while 120-kVp images showed better objective image quality. 70-keV images showed better
objective image quality in the chest. While the subjective image quality of abdominal VNE images was
inferior to that of true non-enhanced images, the improved objective image quality was observed in
VNE images. In the abdominal arterial phase, similar subjective image quality was observed between
the groups. Abdominal 70-keV images in the arterial phase showed improved objective image quality.
Similar image quality was obtained in the abdominal venous phase between the groups. The effective
radiation dose in group 2 showed a significant reduction.

Conclusion:
The application of reduced-dose full-body CT can significantly reduce the radiation dose
for lymphoma patients during the follow-up while maintaining or improving the image quality.
Automatedin silicoEGFR Peptide Inhibitor Elongation using Self-evolving Peptide Algorithm
Authors: Heh Choon Han , Tan Ke Han , Chin Sek Peng 
Published: May 2022

Background:The vast diversity of peptide sequences may hinder the effectiveness of screening for potential peptide therapeutics as if searching for a needle in a haystack. This study aims to develop a new self-evolving peptide algorithm (SEPA), for easy virtual screening of small linear peptides (three to six amino acids) as potential therapeutic agents with the collaborative use of freely available software that can be run on any operating system equipped with a Bash scripting terminal. Mitogen-Inducible Gene 6 (Mig6) protein, a cytoplasmic protein responsible for inhibi-tion and regulation of epidermal growth factor receptor tyrosine kinase, was used to demonstrate the algorithm.Objective:The objective is to propose a new method to discover potential novel peptide inhibitors via an automated peptide generation, docking and post-docking analysis algorithm that ranks short peptides by using essential hydrogen bond interaction between peptides and the target receptor.Method:A library of dockable dipeptides were first created using PyMOL, Open Babel and Au-toDockTools, and docked into the target receptor using AutoDock Vina, automatically via a Bash script. The docked peptides were then ranked by hydrogen bond interaction-based thorough inter-action analysis, where the top-ranked peptides were then elongated, docked, and ranked again. The process repeats until the user-defined peptide length is achieved.Results:In the tested example, SEPA bash script was able to identify the tripeptide YYH ranked within top 20 based on the essential hydrogen bond interaction towards the essential amino acid residue ASP837 in the EGFR-TK receptor.Conclusions:SEPA could be an alternative approach for the virtual screening of peptide sequences against drug targets.
Chemotherapeutic Role of Polyphenols Present in Ocimum sanctum
Authors: Khatoon Saima , Kalam Nida , Balasubramaniam Vinod RMT , Shaikh Mohd. Farooq , Ansari Mohammad Tahir 
Published: May 2022

Abstract:
Ocimum sanctum is a sacred herb of India and is commonly known as ‘Tulsi’ or ‘Holy Basil’ in regional languages of the country. Various parts of O. sanctum are recognised to have remarkable therapeutic efficacy, and are therefore used in Indian traditional medicine system, Ayurveda. Scientific studies have shown that O. sanctum has a range of pharmacological activities. The presence of a substantial amount of polyphenols in O. sanctum could be the reason for its excellent bioactivity. Polyphenols are used to prevent or treat oncologic diseases due to their anti-cancer effects, which are related to activation of apoptotic signaling, cell cycle arrest, binding ability with membrane receptors, and potential effects on immunomodulation and epigenetic mechanisms.

The poor bioavailability of polyphenols restricts their clinical use. The application of nanonization has been implemented to improve their bioavailability, penetrability, and prolong their anticancer action. The present review analyses the recent preclinical studies related to the chemo-preventive and therapeutic potential of polyphenols present in O. sanctum. Moreover, the current article also examines in-depth the biochemical and molecular mechanisms involved in the antineoplastic actions of the considered polyphenols.
Recent Patents on Vascular Stent Material and Its Preparation
Authors: Li Zhaolong , Zhu Wenming 
Published: May 2022

Background:
A vascular stent is a kind of internal stent implanted in the lesion segment when the vessel is stenosis or pathologically expanded, but there will be stenosis complications in the long-term after stent implanta-tion. Therefore, the ideal vascular stent material should have good tissue and blood compatibility, which is the key to controlling the stent in the occurrence of stenosis. Besides, it has good biodegrada-bility, non-toxicity and good mechanical properties. It should be smooth and flexible enough, and the stent should have good compliance when implanted in human body. It should also have biological properties and physiological characteristics that are close to normal blood vessels to ensure that cells can be well attached and grown to avoid any adverse immune exclusion or post-metabolism. The re-sulting undesirable products should finally ensure that the materials are widely available and inexpen-sive, and can be produced on a large scale to meet different clinical needs.

Objective:
In order to solve the long-term complications of stenosis after vascular stent placement, the vascular stent material and its preparation have been continuously optimized and improved.
Methods: A review of various representative patents and papers on vascular stent materials and their p-reparation at home and abroad are reviewed.

Results:
A review of various representative patents and papers on vascular stent materials and their p-reparation at home and abroad are reviewed.

Results:
By summarizing a large number of vascular stent materials and their preparation patents and papers, the preparation methods of vascular stents, the optimization of preparation methods, the performance of vascular stents, and the development trend of vascular stent materials and their preparation a-re discussed.

Conclusion:
The preparation method of the vascular stent material and the optimization of the structure are bene-ficial to improving the performance of the vascular stent material. More related patents and p-apers will appear in the future.
Anti-Cancer Role of Dendrosomal Nano Solanine in Chronic Myelogenous Leukemia Cell Line through Attenuation of PI3K/AKT/mTOR Signaling Pathway and Inhibition of hTERT Expression
Authors: Asgaritarghi Golareh , Farsani Seyedeh Sahar Mortazavi , Sadeghizadeh Dina , Najaﬁ Farhood , Sadeghizadeh Majid 
Published: May 2022

Background:Solanine was primarily known as a toxic compound. Nonetheless, recently the apoptotic role of solanine through suppression of PI3K/AKT/mTOR signaling pathway has been shown against many malignancies except chronic myelogenous leukemia (CML). Sustaining the aforementioned pro-survival pathway, BCR-ABL fused oncoprotein in CML activates NF-kB and c- MYC for apparent immortalizing factor hTERT. Since solanine is a poor water-soluble molecule, herein, a nanocarrier was employed to intensify its pernicious effect on cancerous cells.Objective:The current research aimed at evaluating the effect of dendrosomal nano solanine (DNS) on leukemic and HUVEC cells.Methods:DNS characterization was determined by NMR, DLS and TEM. The viability, apoptosis and cell cycle of DNS and imatinib-treated cells were determined. A quantitative real-time PCR was employed to measure the expression of PI3K, AKT, mTOR, S6K, NF-kB, c-MYC and hTERT mRNAs. The Protein levels were evaluated by western blot.Results:Investigating the anticancer property of free and dendrosomal nano solanine (DNS) and the feasible interplaying between DNS and imatinib on leukemic cells, we figured out the potential inhibitory role of DNS and DNS+IM on cancerous cells in comparison with chemotherapy drugs. Moreover, results revealed that the encapsulated form of solanine was much more preventive on the expression of PI3KCA, mTOR, NF-kB, c-MYC and hTERT accompanied by the dephosphorelating AKT protein.Conclusion:The results advocate the hypothesis that DNS, rather than solanine, probably due to impressive penetration, can restrain the principal pro-survival signaling pathway in erythroleukemia K562 and the HL60 cell lines and subsequently declined mRNA level of hTERT which causes drug resistance during long-term treatment. Additionally, combinational treatment of DNS and IM could also bestow an additive anti-leukemic effect. As further clinical studies are necessary to validate DNS efficacy on CML patients, DNS could have the potency to be considered as a new therapeutic agent even in combination with IM.
WITHDRAWN: Integrated Matrix Incorporating Imidazole Graphene Assembled
Metallic Copper and Silver Nanoparticles to be a Fluidic Antenna
Device
Authors: Abdelrahman Ameen , Erchiqui Fouad , Nedil B M. 
Published: May 2022

:
Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

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A Survey of Explainable Artificial Intelligence in Bio-signals Analysis
Authors: Wei Sow Chen , Choo Yun-Huoy , Muda Azah Kamilah , Sing Lee Chien 
Published: May 2022

Background:
In contrast to the high rate of interest in artificial intelligence (AI) for business, the rate of AI adoption is much lower. It has been found that lack of consumer trust would adversely influence consumer’s evaluations of information given by AI. Hence the need for explanations in model results.

MethodS:
This is especially the case in clinical practice and juridical enforcement where improvements in prediction and interpretation are crucial. Bio-signals analysis such as EEG diagnosis usually involves complex learning models, which are difficult to explain. Therefore, the explanatory module is imperative if results is to be released to the general public. This research shows a systematic review of explainable artificial intelligence (XAI) advancement in the research community. Recent XAI efforts on bio-signals analysis were reviewed. The explanatory models are found to be in favor compared to the interpretable model approach due to the popularity of deep learning models in many use cases.

Result:
The verification and validation of explanatory models appear to be one of the crucial gaps in XAI bio-signals research. Currently, human expert evaluation is the easiest validation approach. Although the human directed approach is highly trusted by the bio-signals community, but it suffers from persona and social bias issues.

Conclusion:
Hence, future research should investigate on more objective evaluation measurements towards achieving the characteristics of inclusiveness, reliability, transparency, and consistency in XAI framework.
Impact of a Long Lockdown on Mental Health and the Role of Media Use: Web-Based Survey Study
Authors: Grygarová Dominika , Adámek Petr , Juríčková Veronika , Horáček Jiří , Bakštein Eduard , Fajnerová Iveta , Kesner Ladislav 
Published: May 2022

Background
Due to the COVID-19 pandemic, the Czech population experienced a second lockdown lasting for about half a year, restricting free movement and imposing social isolation. However, it is not known whether the impact of this long lockdown resulted in habituation to the adverse situation or in the traumatization of the Czech population, and whether the media and specific media use contributed to these effects.

Objective
The aim of this study was to elucidate the effect of the long lockdown on the mental health of the Czech population, and the role of exposure to COVID-19 news reports and specific forms of media news use in mental health.

Methods
We conducted two consecutive surveys in the early (November 2020) and late (March/April 2021) phases of the nationwide lockdown on the same nationally representative group of Czech adults (N=1777) participating in a longitudinal panel study.

Results
Our findings showed that the self-reported symptoms of anxiety and depression increased in the second observation period, confirming the negative effect of the pandemic lockdown as it unfolded, suggesting that restrictive measures and continuous exposure to a collective stressor did not result in the strengthening of resilience but rather in ongoing traumatization. The results also suggest a negative role of the media’s coverage of the COVID-19 pandemic in mental health during the early, and particularly late, phases of the lockdown. Furthermore, we found several risk and protective factors of specific media news use. The media practice in news consumption connected to social media use was the strongest predictor of exacerbated mental health symptoms, particularly in the late phase of the lockdown. Moreover, news media use characterized by internalization of information learned from the news, as well as negative attitudes toward media news, were associated with higher levels of anxiety and depression. Conversely, the use of infotainment, together with an in-depth and contextual style of reading news articles, were related to improvement of mental health.

Conclusions
Our study showed that the long lockdown resulted in traumatization rather than habituation, and in more pronounced effects (both negative and positive) of media use in mental health.
An Adapted Cognitive Behavioral Stress and Self-management Intervention for Sexual Minority Men Living With HIV and Cancer Using the SmartManage eHealth Platform: Protocol and Study Design
Authors: Puccinelli Marc , Seay Julia , Otto Amy , Garcia Sofia , Crane Tracy E , Benzo Roberto M , Solle Natasha , Mustanski Brian , Merchant Nipun , Safren Steven A , Penedo Frank J 
Published: May 2022

Background
Sexual minority men are disproportionately affected by HIV. Medical advances in HIV treatment have extended life expectancy, and as this group ages, medical and psychological challenges become more prominent. Older people with HIV experience a higher incidence of cancer and other comorbidities; these burdens along with sexual minority stress can strain coping resources and diminish health-related quality of life. Interventions such as cognitive behavioral stress and self-management (CBSM) can mitigate some of this burden; however, no manualized, eHealth-based interventions have focused on the unique needs of sexual minority men living with HIV and cancer.

Objective
This study aims to refine and finalize a web-based, CBSM-based intervention to meet the unique needs of this population, including sexual health, comanagement of 2 chronic conditions, and coping with sexual minority stress.

Methods
This mixed methods study used a previously completed qualitative phase (n=6) to inform the development of a web-based platform and intervention called SmartManage. The pilot phase study (n=50) involved randomization (1:1) into either 10 sessions of adapted CBSM or an attention control health promotion. Both conditions used the SmartManage platform, a web-based eHealth program designed to deliver CBSM and health promotion content and host live groups. Feasibility and acceptability (eg, rates of participant engagement and retention) were the primary outcomes.

Results
Participant-related activities are expected to be completed by November 2022, and results are expected to be submitted for publication by February 2023.

Conclusions
We hypothesize that participants would find the intervention acceptable (compared with engagement and retention rates observed in similar CBSM studies). We also hypothesize that participants receiving the SmartManage intervention would have reduced symptom burden and improved health-related quality of life before and after treatment compared with those who do not.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37822
Association Between VDR and CYP24A1 Polymorphisms, Atopic Dermatitis, and Biochemical Lipid and Vitamin D Profiles in Spanish Population: Case-Control Study (Preprint)
Authors: González-Tarancón Ricardo , Goñi-Ros Nuria , Salvador-Rupérez Elvira , Hernández-Martín Ángela , Izquierdo-Álvarez Silvia , Puzo-Foncillas José , Gilaberte-Calzada Yolanda 
Published: May 2022

BACKGROUND

Atopic dermatitis (AD) is the most prevalent inflammatory skin disorder, characterized by impaired epidermal barrier function and an altered immune response, both of which are influenced by vitamin D deficiency. Single-nucleotide polymorphisms (SNPs) in <i>VDR</i> and <i>CYP24A1</i> have been previously associated with AD.

OBJECTIVE

We sought to characterize the associations between the <i>VDR</i> and <i>CYP24A1</i> polymorphisms and the vitamin D and lipid biochemical profile in children diagnosed with AD.

METHODS

A total of 246 participants (143 patients with AD and 103 healthy controls) were enrolled in this study. Genotyping for polymorphisms in <i>VDR</i> (rs2239185, rs1544410, rs7975232, rs2238136, rs3782905, rs2239179, rs1540339, rs2107301, rs2239182, and rs731236) and <i>CYP24A1</i> (rs2248359 and rs2296241) was performed by allele-specific polymerase chain reaction using integrated fluidic circuit technology. Serum levels of calcium, phosphorus, and vitamin D were measured, and the biochemical lipid profile was determined.

RESULTS

Among <i>VDR</i> SNPs, rs2239182 exerted a protective effect against the development of AD, whereas rs2238136 was identified as a risk factor for AD. The GCC haplotype (rs2239185-G, rs1540339-C, and rs2238136-C) appeared to protect against the development of AD. rs2239182-CC was associated with higher 25(OH)D concentrations, whereas rs2238136-TT, rs2239185-GA, and rs2248359-TT were present in a large proportion of patients with serum vitamin D deficiency. rs2239185-AA, rs2239182-CC, and rs1540339-CC were associated with higher serum total cholesterol; rs2239182-TT was associated with lower low-density lipoprotein cholesterol; and rs2239182-TC with lower high-density lipoprotein cholesterol. Both <i>CYP24A1</i> SNPs (rs2296241-AA and rs2248359-TT) were associated with higher high-density lipoprotein cholesterol levels.

CONCLUSIONS

The <i>VDR</i> SNP rs2238136 is a risk factor for AD and other SNPs in <i>VDR</i> and <i>CYP24A1</i>, which may lead to alterations in biochemical parameters that influence the risk of AD. Our findings highlight the complex genetic basis to AD and indicate that interrelationships between different genetic factors can lead to alterations in vitamin D metabolism or lipid profiles, which in turn may influence the development of AD.
La economía poskeynesiana, ¿un pensamiento heterodoxo desconocido?
Authors: Lavoie Marc , Seccareccia Mario 
Published: May 2022

<p>La teoría poskeynesiana es una de las numerosas escuelas de pensamiento heterodoxas en economía. En sus estudios sobre crecimiento y productividad, tiene varias similitudes con la teoría francesa de la regulación, que en Quebec y fuera de Francia es sobre todo conocida en los departamentos de ciencias políticas. En lo que toca a la teoría de precios y empresa, así como en la investigación del mercado laboral, se inspira en gran medida en el trabajo de economistas institucionalistas, tanto de Estados Unidos (EU), como del Reino Unido. Se hace una breve historia del surgimiento de la teoría poskeynesiana. Después, se evocará las principales características de la economía poskeynesiana.</p><div> </div>
Private Eyes and “Little Helpers”: Doormen, Gatekeepers, and Racial Trespass in Chandler's Farewell, My Lovely and Mosley's Devil in a Blue Dress
Authors: Brooks George English 
Published: May 2022

ABSTRACT
Raymond Chandler's and Walter Mosley's protagonists move through different neighborhoods of midcentury Los Angeles and interact with various "gatekeepers" whose function is to maintain and reinforce the racialized urban boundaries of access between LA's neighborhoods, institutions, and other highly regulated public and private spheres. These encounters illuminate anxieties about the stability of racial categories, the physical urban space that these categories would control and organize, and notions of racial and class mobility in midcentury America.