bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF A MODERNIZED AН-26 AIRCRAFT EQUIPPED WITH CONTAINERS WITH MEANS OF PROTECTION AGAINST GUIDED MISSILES
Authors: Kokhan V. , Rashevskyi Y. , Skosyriev A. , Laiske Y. , Lernatovych A. 
Published: May 2022

To date, given the significant losses in the east of our country during the Russian-Ukrainian war, there is an urgent need to provide protection for both the crew and aircraft in general. The retrofitting of the An-26 aircraft with modernized containers with means of protection against guided missiles resolved a number of issues raised. In the course of experimental research, the main combat, technical and operational characteristics of the An-26 aircraft, equipped with modernized containers with means of protection against guided missiles, were determined.
To study the main combat, technical and operational characteristics, an An-26 aircraft was presented, equipped with modernized containers, means of protection against guided missiles: a combined emission device and an optoelectronic countermeasure station.
The An-26 aircraft equipped with modernized containers with means of protection against guided missiles when working on the ground and in flight, is operational.
The main combat, technical and operational characteristics of the An-26 aircraft, equipped with modernized containers with means of protection against guided missiles, generally meet the requirements of regulatory documentation, except for incomplete completeness of optoelectronic countermeasures station, twice limited protection zone of the station in azimuth, and ineffectiveness of aircraft protection by thermal trap emission device in the radar spectral range of wavelengths with the help of pyrocartridges for the radar station of the self-propelled anti-aircraft missile system.
A comparative analysis of the main indicators of tactical and technical characteristics of the An-26 aircraft, upgraded with modernized containers with means of protection against guided missiles, before and after modernization, on the example of prototypes of containers with standard means of protection, reveals advantages and disadvantages of new means of protection.
Rickettsiosis: La importancia de realizar un diagnóstico precoz y manejo temprano.
Authors: Linero Karen , Serrano Samantha , Florián Rodríguez Diana Carolina 
Published: May 2022

La Rickettsia es una bacteria transmitida por vectores como la garrapata, piojos, ácaros entre otros. El ser humano es un hospedero accidental, la rickettsia se transmite al ser humano por medio de la saliva de la garrapata infectada inoculando la bacteria a la piel. Existen diferentes especies de Rickettsia, la especie más importante en América es la Rickettsia rickettssii, reportándose casos en diferentes partes del mundo.
Esta enfermedad se caracteriza por un daño al endotelio de los vasos sanguíneos de pequeño calibre, ocasionando lesiones a nivel pulmonar, cerebral y renal principalmente. Sus manifestaciones clínicas iniciales son inespecíficas y se pueden confundir con otras enfermedades es por lo cual una historia clínica detallada es lo que nos puede llevar a una sospecha diagnóstica temprana.
Esta enfermedad se considera una enfermedad reemergente pese a su amplio conocimiento, debido a su pobre sospecha diagnóstica y prevención. En Panamá desde los años 1950 se diagnosticaron los primeros casos y este año 2021 se diagnosticaron 2 casos en niños en el Hospital del Niño Dr. José Renan Esquivel, los cuales serán los casos que vamos a desarrollar en este artículo.
Diagnóstico diferencial en el paciente con calcificaciones pancreáticas
Authors: Rodríguez Barber Elena , Montserrat Montraveta Querol 
Published: May 2022

La pancreatitis crónica (PC) es una enfermedad de incidencia creciente en la población pediátrica, aunque desconocida, y conlleva una importante comorbilidad. La clínica inicial suele ser la propia de un episodio de pancreatitis aguda pero la importancia recae en el desarrollo, al cabo de meses o años, de insuficiencia pancreática. Para su diagnóstico será necesario tener un alto índice de sospecha clínica y realizar pruebas de imagen que demuestren cambios propios de la PC. El manejo de esta entidad deberá ser multidisciplinar y consistirá en controlar de forma adecuada el dolor e iniciar tratamiento sustitutivo cuando se constate la presencia de insuficiencia pancreática exocrina y endocrina.

El caso que se reporta a continuación es un buen ejemplo de un caso de PC con presencia de insuficiencia exocrina y endocrina. Se documenta el proceso diagnóstico de la PC, en cuanto a pruebas de imagen y pruebas que demuestren la presencia de insuficiencia pancreática. Se exponen también las diferentes pruebas que se realizan para llegar a la etiología del cuadro. Se intenta reflejar el manejo que se debe llevar a cabo en estos pacientes y el seguimiento estricto que requieren.
Improving Health Literacy Knowledge, Behaviors, and Confidence with Interactive Training
Authors: Gibson Cori , Smith Danielle , Morrison Andrea K. 
Published: May 2022

Background:
Ensuring that health care professionals are knowledgeable about the influence limited health literacy has on health outcomes and how to apply health literate strategies is crucial to transform quality and safety in care settings. Although many organizational efforts to address health literacy have focused on hospital settings, few have focused on primary care. The designation of a patient-centered medical home requires the need to address integrating health literacy and the training needs of primary care settings.

Brief description of activity:
An interactive health literacy training intervention was developed, implemented, and evaluated for 25 primary care clinics. This included an online educational module, in-person application activities, and a sustainability plan to continue skill building, reinforce behaviors, and support practice.

Implementation:
Using a descriptive pre- and post-training design, three survey measures were used to rate health literacy knowledge, behaviors, and confidence levels of more than 475 primary care staff. A pre-training survey was completed prior to completion of an interactive online health literacy module and attendance at an in-person training session which followed. A post-training survey was then completed. Sustainment activities, including lunch and learns, and reinforcement activities by clinic leaders, were initiated to promote use of the strategies in practice. A 1-year follow-up survey was then administered to measure sustainability.

Results:
The interactive training intervention improved primary care staff's knowledge, behaviors, and confidence in using health literacy strategies with patients and families. Common barriers and facilitators around the use of these strategies were also identified.

Lessons learned:

Careful consideration should be taken when developing health literacy training to ensure it will be effective, efficient, and sustainable. Using elements that facilitate the transfer of training to practice will help improve success. Addressing barriers and promoting facilitators, as well as integrating and connecting health literacy strategies with existing organizational goals and initiatives offer additional ways to reinforce and sustain the practice change.

[
HLRP: Health Literacy Research and Practice
. 2022;6(2):e113–e120.]

Plain Language Summary:
Clinic staff can improve how they provide information and education to children and families. Interactive training about health literacy led clinic staff to (1) know more about health literacy, (2) use health literacy strategies more, and (3) feel more confident using health literacy strategies. Training over time, supporting staff, and connecting to organizational goals are important for sustainment.
Inadequate Oxygen Delivery Dose and Major Adverse Events in Critically Ill Children With Sepsis
Authors: Roy Katie L. , Fisk Anna , Forbes Peter , Holland Conor C. , Schenkel Sara R. , Vitali Sally , DeGrazia Michele 
Published: May 2022

Background
The inadequate oxygen delivery (IDo2) index is used to estimate the probability that a patient is experiencing inadequate systemic delivery of oxygen. Its utility in the care of critically ill children with sepsis is unknown.

Objective
To evaluate the relationship between IDo2 dose and major adverse events, illness severity metrics, and outcomes among critically ill children with sepsis.

Methods
Clinical and IDo2 data were retrospectively collected from the records of 102 critically ill children with sepsis, weighing &gt;2 kg, without preexisting cardiac dysfunction. Descriptive, nonparametric, odds ratio, and correlational statistics were used for data analysis.

Results
Inadequate oxygen delivery doses were significantly higher in patients who experienced major adverse events (n = 13) than in those who did not (n = 89) during the time intervals of 0 to 12 hours (P &lt; .001), 12 to 24 hours (P = .01), 0 to 24 hours (P &lt; .001), 0 to 36 hours (P &lt; .001), and 0 to 48 hours (P &lt; .001). Patients with an IDo2 dose at 0 to 12 hours at or above the 80th percentile had the highest odds of a major adverse event (odds ratio, 23.6; 95% CI, 5.6-99.4). Significant correlations were observed between IDo2 dose at 0 to 12 hours and day 2 maximum vasoactive inotropic score (ρ = 0.27, P = .006), day 1 Pediatric Logistic Organ Dysfunction (PELOD-2) score (ρ = 0.41, P &lt; .001), day 2 PELOD-2 score (ρ = 0.44, P &lt; .001), intensive care unit length of stay (ρ = 0.35, P &lt; .001), days receiving invasive ventilation (ρ = 0.42, P &lt; .001), and age (ρ = −0.47, P &lt; .001).

Conclusions
Routine IDo2 monitoring may identify critically ill children with sepsis who are at the highest risk of adverse events and poor outcomes.
Alcohol Withdrawal Syndrome in Women vs Men: Analysis of 1496 Cases at a Single Site
Authors: Canales Francisco J. , Davis Jesse , Girgla Navkaran , Emami Maryam , Cooper Tracy , Carlson Richard W. 
Published: May 2022

Background
Studies of alcohol withdrawal syndrome indicate a higher prevalence in men than in women. However, it is unknown how the condition differs between the sexes.

Objective
To assess alcohol withdrawal syndrome in women versus men at a single site.

Methods
All cases of alcohol withdrawal syndrome at a public hospital from 2010 to 2014 were reviewed retrospectively. For all 1496 episodes, age, sex, and admission to a general care unit (ward) versus the medical intensive care unit were ascertained, along with patient survival. A detailed analysis was performed of 437 cases: all 239 patients admitted to the medical intensive care unit, all 99 female patients admitted to the ward, and 99 randomly selected male patients admitted to the ward. Also analyzed were administration of benzodiazepines, disease course, length of stay, and complications.

Results
Men accounted for 92% of all cases (1378 of 1496; P &lt; .001) and medical intensive care unit admissions (220 of 239; P &lt; .05). Sixteen percent of both men and women were admitted to the medical intensive care unit. Men were older (mean age, 45.6 vs 43.9 years; P &lt; .01), and women required more benzodiazepines. Similar rates of complications occurred in both sexes, although women had a higher rate of pancreatitis and men had higher rates of pneumonia, higher rates of sepsis, and longer stays.

Conclusions
Men and women with alcohol withdrawal syndrome have similar complications, courses, and intensive care unit admission rates, although men are more prone to pneumonia and have longer stays.
Standardized Change-of-Shift Handoff: Nurses’ Perspectives and Implications for Evidence-Based Practice
Authors: Rhudy Lori M. , Johnson Maren R. , Krecke Catherine A. , Keigley Danielle S. , Kraft Sarah J. , Maxson Pamela M. , McGill Sharon M. , Warfield Karen T. 
Published: May 2022

Background
Nursing handoff is a communication activity with a high risk for loss or omission of information. Efforts to improve handoffs include standardization of the processes and content of handoff communications.

Objectives
To examine nurses’ perspectives on the structure and organization of change-of-shift handoffs.

Methods
A qualitative descriptive approach was used to conduct a secondary analysis of focus group data. Thirty-four nurses from 4 critical care units participated in focus groups.

Results
Three themes emerged: handoff elements are defined by practice and culture; a clear, consistent, identified structure supports handoff; and personal preferences can disrupt handoff.

Conclusions
A standardized approach to handoff based on unit and organizational needs will be more successful than a broad mandate of content and organization. Individual preference is prevalent and strongly influences the information conveyed and the structure of handoff communication.
Genetic characterization of an isolated alpine population using seroprotein markers: Vallouise (Briançonnais)
Authors: Salis N. , Rabino Massa E. 
Published: May 2022

The aim of the ''Dauphiné Project'' is to reconstruct, with a wide perspective and multidisciplinary approach, the anthropological history of some mountain populations in both the French and Italian parts of the Dauphiné. Mountain populations present peculiarities that make them interesting to anthropology: living in difficult climatic conditions, continuous biological and socio-economic adaptation.
The present study is an analysis of some seroprotein markers in blood samples of subjects living in mountain communities in the Western Alps and native to the area for at least two generations.
The data for these seroprotein systems are the first results of the biological study of populations of the Western Alps. Thus they are an important contribution to our otherwise scanty knowledge about the distribution of these polymorph isms in the populations under study.
Determinants of incomplete vaccination among children 12-23 months in Nigeria
Authors: Ogundele Olorunfemi Akinbode , Ogundele Tolulope , Fehintola Funmito Omolola , Fagbemi Aderonke Tolulope , Beloved Omolola O. , Osunmakinwa Olugbenga Olusegun 
Published: May 2022

Objectives:
The study aimed to assess the prevalence and the determinants of incomplete childhood vaccination in Nigeria.

Materials and Methods:
The data for this study was the 2018 Nigeria Demographic and Health Survey. Multivariable multilevel logistic regression analysis techniques using Stata statistical software (version 13) were used in analyzing the data of 5,384 children aged 12–23 months old.

Results:
About 69.6% of the children were incompletely vaccinated. Individual-level factors such as maternal education, household wealth were associated with incomplete vaccination. The odds of incomplete vaccination among children of mothers without education was 68% higher than those with secondary education and above (adjusted odds ratio [AOR]: (AOR = 1.68; 95% confidence intervals [CI]: 1.56–2.56). Equally children from high wealth index have reduced odds of incomplete vaccination compared to those from low wealth index (AOR = 0.58; 95% CI: 0.47–0.71). Community-level factors such as place of residence, difficulty in getting to health facility were equally associated with vaccination status. The likelihood of incomplete vaccination was 26% higher among children whose parents had difficulty reaching the health facility (AOR = 1.26; 95% CI: 1.11–1.50) than those that did not. In addition, the likelihood of been incompletely vaccinated reduced for children whose mothers live in urban areas (AOR = 0.47; 95% CI: 0.40–0.59).

Conclusions:
Incomplete childhood vaccination is prevalent in the country and associated with various individual and community factors. Program and policies aimed at improving childhood vaccination uptake should target the identified factors.
Stability analysis of the mathematical modelling of transmission and control of rabies incorporating vaccination class
Authors: Somma S.A. , Balogun R.T. , Eguda F.Y. , Abdurrahman N.O. , Adama P.W. , Yisa E.M. 
Published: May 2022

Rabies is a viral disease of nervous system that is often transmitted to human beings through the bite or scratch of rabid animals. The uprising of in-security globally has forced several people to get dogs in their houses. In this paper the mathematical model of rabies transmission and control was formulated by incorporating vaccination class. The Disease Free Equilibrium (DFE) state of the model was obtain and used to compute the basic reproduction number R0 . Local stability analysis of the DFE was carried out using Jacobian Matrix techniques. The DFE is locally asymptotically stable if R0 <1.

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A review on perception of genetically modified foods in Nigeria
Authors: Jibril H. , Dandago M.A. , Abubakar S.A. , Iliyasu R. 
Published: May 2022

Genetically modified foods (GMFs )), GMOs or engineered foods refer to foods produced from genetic ally modified plants or animal s who se DNA have undergone modifications either by an inherent or a foreign DNA (transgenes) for improvement of the targeted o rganism. Genetically modified foods were introduced to Nigeria by National Biotechno logy Development Agency ( to combat food security issues and other agricultural challenges . After the introduction, the Nigerian Government believed that the products can be release d to the m arket. This brought persistent argument s by Nigerians on the perception and acceptance of the GM foods. The basis for the arguments were made on factors such as safety , environmental threat, price , means of colonization, food security, family size, potentiality , awareness of GM foods. These arguments were by individuals and organizations within various areas /fields in Nigeria. The perception led to the division of Nigerians to protagonists and antagonist s with regards to GMOs. The article reviewed the introduction, perceptions and views of factors on GMFs acceptance among Nigerians.
Vitis vinifera seed extract ameliorates streptozotocin ind uced pancreatic dysfunction by reducing interleukin 1β and up regulation of omentin 1 mRNA
Authors: Salah Karima Bel Hadj , Al-Quwaie Diana AH , Binothma Najat , Aljadani Majidah , Mansoury Manal MS , Alsubhi Nouf H , Alrefaei Ghadeer I , Bayoumi Ammar A , Ibrahim Maha , Khattab Hala AH 
Published: May 2022

Purpose: To investigate the effect of ethanol seed extract (SE) on pancreatic function markers associated with streptozotocin-induced diabetes in rats.
Methods: Non-diabetic rats (n = 12) were divided into 2 groups (GRPs); GRP1 served as the control, and GRP2 was administered orally with V. vinifera SE (500 mg/kg). Diabetic rats were divided into 2 GRPs; GRP3 served as the streptozotocin-induced diabetic rats, and GRP4 diabetic rats received V. vinifera SE (500 mg/kg). Blood was collected at the end of 4 weeks, and serum glucose and lipid profile were measured using colorimetric enzymatic kits. Serum insulin, and interleukin-1 beta (IL-1β) levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Histopathological alterations in pancreas were determined, while omentin-1 mRNA expression was investigated using quantitative real time-polymerase chain reaction (qRT-PCR).
Results: V. vinifera SE protected pancreatic function in diabetic rats. V. vinifera SE significantly increased serum insulin and HDL (p < 0.001), besides significantly decreasing serum glucose, cholesterol, triglyceride, and LDL (p < 0.001). Pathological studies also showed that V. vinifera SE preserved the pancreatic β cells’ shape, size, and cell population in the diabetic GRP. The extract significantly decreased serum IL-1β levels in diabetic rats (p < 0.001). Besides, the data demonstrated a significant up-regulation in omentin-1 mRNA expression in diabetic rats treated with V. vinifera SE.
Conclusion: V. vinifera SE has anti-diabetic and anti-hyperlipidemic properties in streptozotocin-induced rat model. The underlying mechanism of action might be a decrease in the pro-inflammatory cytokine (IL-1β) and increase in omentin mRNA. Clinical trials are required to validate these findings
Knockdown of PRUNE2 alleviates hypoxia induced oxidative stress inhibits cell proliferation in trophoblast cells, and reverses LY294002 induced PI3K/AKT pathway inhibition
Authors: Wang Jing , Zhao Yanping 
Published: May 2022

Purpose: To investigate the probable effect of PRUNE2 on viability, motility, and oxidative stress of hypoxia-induced trophoblast cells, and the mechanism of action involved.
Methods: Trophoblast cells were treated with 250 μM CoCl2 for 24 h to simulate hypoxia. Then, a cell counting kit (CCK-8), colony formation, and flow cytometry (FCM) were used to determine the role of PRUNE2 in cell viability. Wound closure, as well as Transwell-migration assay, were conducted to evaluate cell motility. Superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO) levels were determined using the appropriate kits, while the effects of PRUNE2 on PI3K/AKT pathway in trophoblast cells were assessed by immunoblot assay. LY294002 was used to inhibit PI3K/AKT pathway in trophoblast cells.
Results: The hypoxia-induced trophoblast cell model was successfully constructed. The data showed that PRUNE2 was overexpressed in hypoxia-induced trophoblast cells, and that ablation of PRUNE2 stimulated proliferation as well as motility of hypoxia-induced trophoblast cells (p < 0.01). Depletion of PRUNE2 reduced oxidative stress in the cells. PRUNE2 mediated PI3K/AKT pathway and thus affected the proliferation, motility, and oxidative stress of trophoblast cells (p < 0.01). In addition, depletion of PRUNE2 reversed PI3K/AKT signaling and the inhibition of trophoblast proliferation induced by t PI3K/AKT inhibitor LY294002.
Conclusion: PRUNE2 depletion alleviates hypoxia-induced oxidative stress, inhibits cell proliferation in trophoblast cells and reverses LY294002-induced PI3K/AKT pathway inhibition. The findings suggest that PRUNE2 could act as a target treatment for PE.
Implications of statin metabolism related gene testing in guiding individualized drug use in cardiovascular diseases
Authors: Zhang Yiliang , You Xiaofan , Ren Yuyan , Cui Jinpeng 
Published: May 2022

Purpose: To determine the value of statin metabolism-related gene testing in guiding individualized drug use in cardiovascular and cerebrovascular diseases.
Methodology: A total of 158 eligible patients with cardiovascular and cerebrovascular diseases in the Outpatient Department, Yantai City Yantaishan Hospital, Laishan District, Shandong Province were recruited and assigned based on their diseases to group A (81 patients with coronary heart disease), group B (77 patients with cerebral infarction). The control group comprised 75 healthy individuals.
Results: The GG, GT, and TT genotypes in ABCB1 (2677G > T) in group A had a G allele frequency of 0.556 and a T allele frequency of 0.444, while CC, CT, and TT genotypes in ABCB1 (3435C > T) in group A had a C allele frequency of 0.555 and a T allele frequency of 0.445. Significant differences were observed in the effectiveness of statins in treating patients with different genotypes (p < 0.05).
Conclusion: Genetic testing related to statin metabolism is of significant value in guiding the use of medication in patients with cardiovascular disease, as most of these patients present with dyslipidaemia. Significant individual differences in gene polymorphisms exist between patients with the same disease.