bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Patterns of Gene Expression and Regulatory Variation in seed coat of Maize
Authors: Li Juan , Wang Liangfa , Wan Jiong , Dang Kuntai , Lin Yuan , Meng Shujun , Qiu Xiaoqian , Wang Qiyue , Zhao Jiawen , Mu Liqin , Luo Hongbing , Ding Dong , Chen Zehui , Tang Jihua 
Published: June 2022

Abstract
Background：Seed size is an important factor contributing to maize yield, of which the molecular mechanism remains elusive. Seed coat, serves as one of the three components of maize grain, determines the seed size to a certain extent. The seed coat is a complete maternal genotype and is an ideal material for studying heterosis.ResultsIn this study, the self-pollinated seeds of maize hybrid Yudan888 and its parental lines were continuously collected from 0DAP to 15DAP for phenotyping, cytological observation and RNA-seq. The phenotypic data showed that 3DAP and 8DAP are the best time points to study maize seed coat heterosis. Cytological observations indicated that heterosis in maize seed coat was dependent much on cell numbers other than cell size. Furthermore, RNA-seq indicats that the number of non-additive genes changed significantly. However, the number of genes expressed in heterozygotes and the number of genes expressed additively were not significantly different. Our findings suggest that seed coat heterosis, in hybrid Yudan888, is the result of non-additive expression caused by the dynamic changes of genes at different time points along seed expanding and seed coat development. This dynamic change suggests that a dose effect of gene expression results in Yudan888 seed coat heterosis. Go enrichment and KEGG analysis indicated that genes related to DNA replication, cell cycle regulation, circadian rhythms and metabolite accumulation contributed significantly to Yudan888 seed coat heterosis.ConclusionThe maize seed coat area phenotyping allows us to infer that 3DAP and 8DAP are important time points in the study of seed coat heterosis. Our findings provide evidence for genes involved in DNA replication, cell cycle regulation, circadian rhythms and metabolite accumulation in hybrid with high or low parental expression as major contributors to Yudan888 seed coat heterosis.
Antiviral activity of new flavonoids-containing phytopreparation against human alphaherpesvirus 2, hepatitis C virus, and coronavirus
Authors: Galkin Alexander , Arkhypova Maryna , Starosyla Daria , Deriabin Oleg , Vasylchenko Oleksandr , Rybalko Svitlana , Golembiovska Olena 
Published: June 2022

Abstract
The antiviral activity of the complex phytopreparation (alcohol tincture of Filipendula vulgaris, Petroselinum crispum, Apium graveolens radices; Galium verum, Linaria vulgaris herbs; Calendula officinalis flowers) was evaluated on the in vitro models of current uncontrolled viral infections: human alphaherpesvirus 2, hepatitis C (surrogate bovine diarrhea virus) and coronavirus of transmissive porcine gastroenteritis (TGEV) and demonstrated its high antiviral activity to all tested viruses. The phytopreparation solution is an active inhibitor of human alphaherpesvirus 2, hepatitis C surrogate virus (BVDV), and TGEV coronavirus reproduction with a selectivity index of 80, 320, and 320, respectively. In the guinea pig genital herpes in vivo experimental model, it was shown that phytopreparation solution (dilution of 1:100) in case of a combined treatment regimen (per os + application) delayed the onset of the infection's first symptoms and reduced the time of disease duration. The index of phytopreparation therapeutic action was at the same level as the Acyclovir (reference antiherpetic drug). The investigation of phytopreparation's mechanism of antiviral action allowed supposing that it could be realized via the induction of αIFN, inhibition of RNA, and DNA synthesis.
Efficacy prediction of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) in breast cancer patients and their variations after Neoadjuvant chemotherapy
Authors: Ni Jingyi , Jin Conghui , Qi Xue , Xu Weiwei , Li Xinghui , Song Li , He Feng , Zhang Xunlei 
Published: June 2022

Abstract
Objective: The objective of this study is to evaluate the efficacy prediction values of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) in breast cancer patients who received neoadjuvant chemotherapy.Methods: We registered a retrospective study include 72 breast cancer patients between February 2020 and January 2022. All patients had axillary lymph node metastasis receiving neoadjuvant therapy. Calculating PNI, SII before and after therapy were examined through blood routine. Chi-square test was used to compare the clinicopathological and laboratory parameters between groups. Using the logistic regression analysis to evaluate the prognosis values of the factors.Results: 18 patients (25%) achieved pathologic complete response (pCR) after neoadjuvant therapy. The pCR rate of breast patients had significant relationship with ER, PR, HER-2, molecular subgroup, tumor size, vascular invasion, nerve invasion, N stage, clinical stage and chemotherapy regimen. Low ΔPNI, high ΔSII and higher ΔPNI-ΔSII score values had better prediction of therapeutic effect, especially the ΔPNI-ΔSII score.Conclusion: The ΔPNI-ΔSII score may be an effective efficacy prediction index in breast cancer patients receiving neoadjuvant chemotherapy, which can help to identify high-risk groups and efficacy evaluation.
Spatiotemporal Rainfall Projection in Majalaya basin, West Java, Indonesia under CMIP6 Scenarios
Authors: Sa’adi Zulfaqar , Rohmat Faizal I. W. , Stamataki Ioanna , Shahid Shamsuddin , Iqbal Zafar , Yaseen Zaher Mundher , Yusop Zulkifli , Alias Nor Eliza 
Published: June 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Determination of total Arsenic (As) in Feed and Meat of the Chicken. A case study from Khyber Pakhtunkhwa (KPK) Pakistan
Authors: Idrees Muhammad , Hussain Shah 
Published: June 2022

Abstract
Arsenic concentration was evaluated in different parts of the chicken and ingredients of the feed used for the chicken feed. Arsenic was found in different feed ingredients and parts of the chicken though variations were found in the concentration of arsenic in meat and feed samples. Chicken stomach and liver were the major parts of the samples where higher arsenic concentrations were determined. Arsenic concentration in feed ingredients and meat samples ranged from 0.00-0.013 mg/Kg and 0-0.1566 mg/Kg respectively. Arsenic concentration in N long thigh, N liver, N stomach and C breast were found higher than WHO/FAO permissible limit of 0.1 mg/Kg while in other samples it was found within the limits of WHO/FAO. Estimated daily intake (EDI), target hazard quotient (THQ) and cancer target risk (CTR) were used to assess the risk of arsenic for chicken users in KPK, Pakistan. EDI was found between 0.0562–0.224 mg/Kg. THQ were found lower than 1. Considering the presence of arsenic in feed ingredients and meat samples the present study is very useful and provide fruitful information for the users of chicken meat in KPK Pakistan.
Landscape Changes in a Critical Subtropical Coastal Wetland in Northwestern Mexico: Is Shrimp Farming a Driver of Concern?
Authors: Castellanos-Tapia Fernando , Fernández Guillermo , Ruiz-Luna Arturo , Cervantes-Escobar Aimée , Berlanga-Robles César A. 
Published: June 2022

Abstract
Coastal wetlands are critical ecosystems that are under intense pressure due to anthropogenic activities. In addition to urban growth and agriculture, shrimp farming has become one of the main drivers behind the loss of tropical and subtropical coastal wetlands. Despite its socio-economic importance, shrimp farming has high environmental costs worldwide. Consequently, it is essential to monitor shrimp farming at regional and local scales to determine if the resulting pressure on coastal wetlands is increasing. We analyzed land use/land cover (LULC) in the Bahía Santa Maria-La Reforma (BSMR) lagoon system in northwestern Mexico using remote sensing data to determine landscape and surface cover changes. We also projected future scenarios based on stochastic models and evaluated landscape metrics considering the effects of shrimp farming. Four LULC thematic maps (1985, 1994, 2002, and 2017) with overall accuracy values > 80% and two projected maps (2027 and 2037) were produced. Agriculture was the dominant LULC class in the BSMR coastal lagoon system, although saltmarshes appear as the most critical wetland type in the area. Shrimp farming, which was nonexistent in 1985, represented 4% of the total landscape in 2017. By 2037, this value is expected to increase to 5%. Saltmarshes showed negative trends due to the expansion of shrimp farming. Considering the importance of wetlands given their ecosystem services, this study highlights LULC changes due to economic activities and the need to improve management strategies to protect the wetlands of the BSMR coastal lagoon system.
Experimental study on the rise of aqueous foams in vertical pipes
Authors: Salazar V. S. Álvarez , Sigalotti L. Di G. , Ovando A. Medina , Klapp J. , Carvajal-Mariscal I. 
Published: June 2022

Abstract
In this paper we report experiments on the growth of dry foams
and their rise in thin vertical pipes of different circular
cross-sectional radii. Air injection at the bottom of the
pipes is performed at a constant flow rate by means of a single
capillary tube. The formation and rising of the foam was investigated
for two different cases: (a) when the top cap of the vertical
pipes is open and (b) when it is closed. We find that the position
and velocity of the foam front as well as the foam dispersivity are
both dependent on the pipe diameter and on whether its top end is
open or capped. When the top is open, the foam column grows faster
compared to the case when it is sealed. In pipes of small diameters,
the growth rate is nonlinear and faster than in pipes of large
diameters in which cases the foam rises at an almost constant rate.
As the diameter of the pipe increases, the size of the produced
bubbles also increases. In closed-top pipes the foams tend to be
more homogeneous than in open top pipes. The experimental observations
indicate that under foam drainage driven by gravity, the liquid flow
velocity across the Plateau borders is indicative of a drainage model
based on a plug-like flow in channels with fully mobile interfaces,
where viscous dissipation occurs only in the nodes.
Executive function difficulties among school-aged children during the COVID-19 pandemic: associations with home literacy environment, reading and screen media times
Authors: Tabullo Angel Javier , Canet-Juric Lorena , Abusamra Valeria 
Published: June 2022

Abstract
Several studies indicated that the COVID-19 pandemic and the containment measures it required (including social distancing, quarantine and school closure) had a significant impact on children’s mental health. The present study aimed to examine executive function difficulties at behavioural level in school children during the COVID-19 lockdown, and to analyze potential associations with home literacy environment, current reading and screen times. Data were collected from mothers of 210 children (9–12 years old) through an online survey. Significant increases in children screen times were observed, while most of them did not read for pleasure on a daily basis. Parents’ literacy beliefs and children’s current leisure reading times were negative predictors of executive function difficulties, which increased with videogame and internet exposure. Nevertheless, perceived changes on screen or reading times with respect to pre-pandemic levels were not associated with executive function scores. The results might indicate: 1) opposite effects of literacy and screen times over children’s executive functioning; 2) a preference for reading or screen recreational use according to their executive function profiles; or 3) a combination of both. Our findings highlight the relation of reading and screen times with children’s cognitive development, and the importance of following their trajectory during post-pandemic times.
Relativity and View Effects
Authors: Fischli Bernard 
Published: June 2022

Abstract
This paper describes a new interpretation of relativity.The concept of rest frames of the observer and the object clarifies the initial assumptions used in General Relativity and underlines the necessity to review whatever impacts relativity. Relativistic view effects modifying the path of information carriers are examined in addition to interactions. The Ehrenfest paradox is solved, and it is not compatible with a curved space. View effects specific to each point of view are the solution. The concept of a seen speed is introduced.The calculation of the deflection of light by the sun explains in detail why the deflection angle must be double the value obtained with Newton’s laws. This is due to gravitation as well as to relativistic view effects. As already noted by Einstein the deflection of light can only take place if the speed of light varies in vacuum. This is done by gravitation.The compatibility of General Relativity with the new interpretation is discussed. The main argument for this compatibility is due to the use in General Relativity of a Pseudo-Riemannian geometry describing intrinsic views which introduce the rest frame concept. They are compatible with view effects. Differences subsist regarding energy.Relativistic energy is examined. The relationship of Special Relativity between speed and energy is confirmed for electromagnetism where path speeds are limited to the speed of light. Such speed limits do not apply to gravitation where total energy is composed of rest mass energy plus a kinetic energy as defined in classical mechanics.Relativistic view effects are specific to electromagnetism. When gravitation acts on objects that transfer their path information by photons, the paths of these photons will be impacted by view effects modifying that information.
ÇOCUK HAKLARI SÖZLEŞMESİNE TARAF OLMAYAN ÜLKE: AMERİKA BİRLEŞİK DEVLETLERİ
Authors: YAMAN Fikret 
Published: June 2022

1990 yılında yürürlüğe giren Birleşmiş Milletler (BM) Çocuk Haklarına Dair Sözleşme, uluslararası insan hakları belgeleri arasında en yaygın kabul gören Sözleşme konumundadır. Amerika Birleşik Devletleri, mezkûr Sözleşmenin hazırlanmasında aktif olarak yer almış ve diğer ülkelerin Sözleşmeyi imzalaması ve onaylaması için girişimlerde bulunmuştur. Bununla birlikte, ABD, BM üyesi bütün ülkeler (196 ülke) içinde Sözleşmeye taraf olmayan tek ülkedir. ABD, Sözleşmenin hazırlanmasındaki öncü rolü ve yöneltilen bütün eleştirilere rağmen Sözleşmeye taraf olmama tutumunu sürdürmektedir.
Aile kurumuna zarar verme ve ebeveynlerin çocuklarını kendi inançlarını göre yetiştirme hakkını ihlal etme iddiaları başta olmak üzere ABD’nin mezkûr Sözleşmeye neden taraf olmaması ile ilgili temel argümanların Türkiye kamuoyuna bilimsel anlamda ilk defa taşınıyor olması bu çalışmayı önemli kılmaktadır.
Microstructure models of cement: their importance, utility, and current limitations
Authors: Bishnoi Shashank , Bullard Jeffrey W. 
Published: June 2022

Microstructure models seek to explain or predict various material properties in terms of the structure or chemical composition at scales of several hundred nanometres to several hundred micrometres. Such models therefore bridge the scaling gap between atomistic models and continuum methods, and consequently can help establish and validate scaling relations across those scales. Microstructure models have been applied to cementitious materials for at least four decades to help understand setting, strength development, rheological properties, mechanical behavior, and transport properties. This letter describes the current state of cement microstructure modelling in several areas that are important for engineering. It is not meant to be an exhaustive review, instead highlighting the kinds of models that can now be applied to different aspects of cement binder behaviour. Special attention is paid to challenges or limitations of each kind of model. This is done to promote the judicious use and interpretation of models and especially to indicate where future research could make inroads on problems that are currently inaccessible to microstructure models.
Assessing an Internet-Delivered, Emotion-Focused Intervention Compared With a Healthy Lifestyle Active Control Intervention in Improving Mental Health in Cancer Survivors: Protocol for a Randomized Controlled Trial
Authors: Smith Isabelle S , Wallace Rebecca , Wellecke Cornelia , Bind Marie-Abèle , Weihs Karen L , Bei Bei , Wiley Joshua F 
Published: June 2022

Background
Cancer survivors are vulnerable to experiencing symptoms of anxiety and depression and may benefit from accessible interventions focused on improving emotion regulation. CanCope Mind (CM) was developed as an internet-delivered intervention adapted from the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders to improve emotion regulation and support the mental health of cancer survivors.

Objective
This protocol aims to provide an outline of the CanCope Study, a trial comparing the efficacy of a Unified Protocol–adapted internet-delivered intervention (CM) designed for cancer survivors compared with an active control condition—an internet-delivered healthy lifestyle intervention, CanCope Lifestyle (CL). The primary aim is to assess and compare the efficacy of both interventions in improving emotion regulation, anxiety and depressive symptoms, and quality of life. The secondary aims involve assessing the mechanisms of the CM intervention.

Methods
This trial is a 2-arm randomized controlled trial that allocates cancer survivors to either CM or CL. Both interventions comprise 4 web-based modules and are expected to take participants at least 8 weeks to complete. Participants’ mental and physical health will be assessed via self-reported surveys at baseline (T0), between each module (T1, T2, and T3), immediately after the intervention (T4), and at 3-month follow-up (T5). The study aims to recruit 110 participants who have completed T4.

Results
The CanCope study began recruitment in September 2020. A total of 224 participants have been randomized to the CM (n=110, 49.1%) and CL (n=114, 50.9%) groups.

Conclusions
This is one of the first trials to develop and investigate the efficacy of a web-based intervention for cancer survivors that specifically targets emotion regulation.

Trial Registration
Australian Clinical Trials ACTRN12620000943943; https://tinyurl.com/b3z9cjsp

International Registered Report Identifier (IRRID)
DERR1-10.2196/36658
Effect of Myofascial Release as an Adjunct with Conventional Therapy on Range Of Motion and Pain in Post Traumatic Knee Stiffness
Authors: Gayatri Sunil Landge  , Dr. Amrutkuvar Rayjade  
Published: June 2022

Post traumatic stiffness and pain are the two main complications which occur after any severe trauma to the knee. Fascia and muscular structures are the major causes for developing stiffness but they are ignored by many physiotherapists as they only focus on intra-articular causes of stiffness. Therefore less research work is available on the effect of myofascial release (MFR) on post-traumatic knee stiffness. Myofascial release can provide immediate effects on stiffness which can be more beneficial if given with conventional protocol of physiotherapy. So it is necessary to study the effect of myofascial release with conventional therapy. To study the effect of myofascial release as an adjunct with conventional therapy on range of motion and pain in post traumatic knee stiffness, 24 subjects of post traumatic knee stiffness both males and females were selected. Their consent was taken and they were given conventional physiotherapy treatment with myofascial release technique. Results were obtained by pre test and post test assessment of visual analogue scale (VAS) and range of motion analysis. According to the statistical analysis of pre test and post test assessment it was found that myofascial release technique significantly improves the range of motion and reduces the pain of affected knee joints. MFR is effective in improving the range of motion and decreasing the pain of affected knee joints in case of posttraumatic knee stiffness when given with conventional physiotherapy protocol.
BIMBINGAN KELOMPOK MELALUI TEKNIK ROLE PLAYING TERHADAP PERILAKU BULLYING SISWA SMA
Authors: Wulandari Irma , Irmayanti Rima 
Published: June 2022

The purpose of this research was to determine the use of group guidance services with role playing techniques to overcome the bullying behavior of high school students. Bullying behavior is a problem that is often faced by adolescent peer refusal to lead to the emergence of bullying behavior in students. Increased cognitive abilities and awareness of adolescents can prepare teens to deal with stress and emotional fluctuations effectively, many adolescents cannot manage their emotions effectively. As a result, adolescents are prone to anger, less able to control emotions, which can then lead to the emergence of various problems with negative emotions, one of which is bullying. The method used in this research is a literature review that refers to previous studies and based on data from related sources. Based on the results of several previous studies indicate that the implementation of group guidance with effective role playing techniques and helps in overcoming the bullying behavior of high school students.Keywords: Bullying, Group Guidance, Role Playing
SELF DISCLOSURE DALAM KOMUNIKASI INTERPERSONAL: KESETIAAN, CINTA, DAN KASIH SAYANG
Authors: Septiani Dila , Azzahra Putri Nabilla , Wulandari Sari Nurul , Manuardi Ardian Renata 
Published: June 2022

Self disclosure dalam komunikasi interpersonal sangat berpengaruh bukan hanya pada kehidupan sehari-hari tetapi juga di masa yang akan datang. Manusia merupakan makhluk sosial yang tidak bisa bergantung hidup sendiri, pun manusia mempunyai fitrah tersendiri yang diciptakan Tuhan, seperti kesetiaan, cinta dan kasih sayang. Hal itu sangat penting ketika berkomunikasi berlangsung. Self disclosure sendiri juga berarti keterbukaan diri yang mana setiap makhluk sosial yakni manusia harus mempunyai keterbukaan dirinya. Setiap manusia seringkali menutupi atau merahasiakan informasi dirinya terhadap orang lain, sehingga sebagian manusia tidak percaya akan kepada dirinya sendiri. Melalui komunikasi individu dapat memenuhi kebutuhan emosional dan meningkatkan kesehatan mentalnya. Belajar untuk memaknai apa itu kesetiaan, cinta dan kasih sayang pun sangat perlu karena dapat seseorang dapat mengalami berbagai macam kualitas perasaan dan membandingkan perasaan dengan yang lainnya. Kata Kunci: Self Disclosure, Komunikasi Interpersonal, Kesetiaan, Cinta, dan Kasih Sayang