bluuebunny/crossref_metadata_2025_split huggingface dataset:
A smart admission control and cache replacement approach in content delivery networks
Authors: Abdo Lamis , Ahmad Imtiaz , Abed Sa’ed 
Published: August 2022

Abstract

Content Delivery Networks (CDNs) distribute most data traffic nowadays by caching the contents in a network of servers to provide users with the requested objects, and helping to reduce latency when delivering contents to the user. The content caching system performance depends upon many factors such as where the objects should be stored, which object to store, and when to cache them. The proposed methodology includes two main phases: an admission control phase and a cache replacement phase. The admission control phase is responsible for accepting or rejecting the incoming request based on training the Reinforcement Learning (RL) algorithm to make the best decision in the near future to maximize its reward, which, in this case, is the hit ratio. The cache replacement phase estimates the object’s future popularity. This is achieved by building a predictive model based on the popularity prediction mechanism, where the Long-Short-Term Memory (LSTM) model is used to compute the object’s popularity. The LSTM model’s outcome can help decide which objects to cache and which objects to evict from the cache. The proposed methodology is tested on a dataset to demonstrate its effectiveness in enhancing the hit ratio compared to conventional replacement policies such as First-in-First-Out (FIFO), Least Recently Used (LRU), Least Frequently Used (LFU) and a recent machine learning-based algorithm. The experimental results on the dataset revealed that the proposed methodology outperformed the baseline algorithms by 34.7% to 97.17% with a cache size of 130.
A two-step non-nominal troposphere monitor for GBAS
Authors: Li Jiaxiang , Yin Hao , Cheng Jianhua , Li Liang , Jia Chun , Jiang Jiachang 
Published: August 2022

Abstract
The non-nominal troposphere caused by hazardous horizontal gradients poses a threat to the accuracy and integrity of the safety-critical civil aviation precision approach. The carrier phase-based monitors are widely applied for evaluating and detecting the non-nominal troposphere. However, the detection sensitivity of carrier phase-based monitor is significantly limited by the reliability of ambiguity resolution. A two-step non-nominal troposphere monitor is proposed based on the parallel short-baseline reference receivers. The probabilities of false alarm and missed detection are dynamically allocated between the two-step monitoring of ambiguity resolution and non-nominal troposphere sequentially. The real BDS dual-frequency data are utilized to test the proposed two-step monitoring method. The result shows that the proposed two-step monitor with the dynamic allocation can obtain the detection sensitivity improvement by 40.5% when compared with the fixed allocation method. It has been demonstrated that the proposed monitor can effectively reduce the integrity risk of high-precision navigation service caused by non-nominal troposphere.
Two firing modes and well-resolved Na + , K + , and Ca 2+ currents at the cell-microelectrode junction of spontaneously active rat chromaffin cell on MEAs
Authors: Marcantoni Andrea , Chiantia Giuseppe , Tomagra Giulia , Hidisoglu Enis , Franchino Claudio , Carabelli Valentina , Carbone Emilio 
Published: August 2022

Abstract
We recorded spontaneous extracellular action potentials (eAPs) from rat chromaffin cells (CCs) at 37°C using microelectrode-arrays (MEAs) and compared them with intracellularly recorded APs (iAPs) through conventional patch-clamp recordings at 22°C. We show the existence of two distinct firing modes on MEAs: a ~ 4 Hz irregular continuous firing and a frequent intermittent firing mode where periods of high-intraburst frequency (~ 8 Hz) of ~ 7 s duration are interrupted by silent periods of ~ 12 s. eAPs occurred either as negative- or positive-going signals depending on the contact between cell and microelectrode: either predominantly controlled by junction-membrane ion channels (negative-going) or capacitive/ohmic coupling (positive-going).Negative-going eAPs were found to represent the trajectory of the Na+, Ca2+ and K+ currents passing through the cell area in tight contact with the microelectrode during an AP (point-contact junction). The inward Nav component of eAPs was blocked by TTX in a dose-dependent manner (IC50 ~ 10nM) while the outward component was almost fully attenuated by the BK channel blocker paxilline (200nM) or TEA (5mM). The SK channel blocker apamin (200nM) had no effect on eAPs. Inward Nav and Cav currents were well-resolved after block of Kv and BK channels in cells exhibiting no evident outward K+ currents. Unexpectedly, on the same type of cells, we could also resolve inward L-type currents after adding nifedipine (3µM). In conclusion, MEAs furnish a direct way to record different firing modes of rat CCs and to estimate the Na+, Ca2+ and K+ currents that sustain cell firing and spontaneous catecholamines secretion.
Development and Validation of a Glioma-Associated Mesenchymal Stem Cell-Related Gene Prognostic Index for Predicting Prognosis and Guiding Individualized Therapy in Glioma
Authors: Peng Zesheng , Wu Yuxi , Wang Jiajing , Gu Sujie , Wang Yihao , Xue Bingzhou , Fu Peng , Xiang Wei 
Published: August 2022

Abstract
Background: Recent studies have demonstrated that glioma-associated mesenchymal stem cells (GA-MSCs) are implicated in the regulation of glioma malignant progression. However, the prognostic value of GA-MSCs has not been comprehensively explored in glioma.Methods: We extracted GA-MSCs from glioma tissues, established intracranial xenograft models in nude mice, and obtained GA-MSC-related genes (GA-MSCRGs) by using microarrays. The transcriptome data and clinical information of glioma patients were obtained from the CGGA and TCGA databases. We screened 8 prognostic GA-MSCRGs to construct a prognostic index by using the multivariate Cox regression method. The validity of the GA-MSCRGPI was verified in the training (CGGA693) and validation (TCGA and CGGA325) cohorts. The expression patterns of these 8 GA-MSCRGs were validated in 78 glioma tissue specimens by using a qRT‒PCR assay.Results: GA-MSCs were successfully isolated from glioma tissues. Based on intracranial xenograft models and transcriptome microarray screening, 8 genes (MCM7, CDK6, ORC1, CCL20, TNFRSF12A, POLA1, TRAF1 and TIAM1) were selected for the construction of a GA-MSC-related gene prognostic index (GA-MSCRGPI). In both the training and validation cohorts, high GA-MSCRGPI patients showed an inferior survival outcome compared with low GA-MSCRGPI patients. A nomogram was established based on independent prognostic indicators (PRGPI, age and WHO grade) and exhibited a strong forecasting ability for overall survival (OS). Moreover, we found that the GA-MSCRGPI could evaluate the prognosis of glioma patients undergoing chemoradiotherapy. The high GA-MSCRGPI group exhibited higher immune, stromal and ESTIMATE scores; lower tumor purity; higher infiltration of Tregs and M2-type macrophages; fewer activated NK cells; and higher expression of immune checkpoints. Tumor Immune Dysfunction and Exclusion (TIDE) showed that the high GA-MSCRGPI group had more responders to ICI therapy. The results of the genetic mutation profile and tumor mutation burden (TMB) in different GA-MSCRGPI subgroups further supplement GA-MSCRGPI-related mechanisms. Finally, the expression patterns of 8 selected GA-MSCRGs in GA-MSCRGPI were correlated with glioma WHO grades to a certain extent.Conclusion: The constructed GA-MSCRGPI could predict prognosis and guide individualized therapy in glioma patients.
The use of Foundational Ontologies in Bioinformatics
Authors: Bernabé César H. , Queralt-Rosinach Núria , Souza Vítor E. Silva , Santos Luiz Olavo Bonino da Silva , Mons Barend , Jacobsen Annika , Roos Marco 
Published: August 2022

Abstract
Background: The FAIR principles recommend the use of controlled vocabularies, such as ontologies, to define data and metadata concepts. Ontologies are currently modelled following different approaches, sometimes describing conflicting definitions of the same concepts, which can affect interoperability. To cope with that, prior literature suggests organising ontologies in levels, where domain specific (low-level) ontologies are grounded in domain independent high-level ontologies (i.e., foundational ontologies). In this level-based organisation, foundational ontologies work as translators of intended meaning, thus improving interoperability. Despite their considerable acceptance in bioinformatics, there are very few studies testing foundational ontologies. This paper describes a systematic literature mapping that was conducted to understand how foundational ontologies are used in bioinformatics and to find empirical evidence supporting their claimed (dis)advantages. Results: From a set of 79 selected papers, we identified that foundational ontologies are used for several purposes in bioinformatics: ontology construction, repair, mapping, and ontology-based (federated) data analysis. Foundational ontologies are claimed to improve interoperability, enhance reasoning, speed up ontology development and facilitate maintainability. The complexity of using foundational ontologies is the most commonly cited downside. Despite being used for several purposes, there were hardly any experiments (1 paper) testing the claims for or against the use of foundational ontologies. In the subset of 49 papers that describe the development of an ontology, it was observed a low adherence to ontology construction (16 papers) and ontology evaluation formal methods (4 papers). Conclusion: Our findings have two main implications. First, the lack of empirical evidence about the use of foundational ontologies indicates a need for evaluating the use of such artefacts in bioinformatics. Second, the low adherence to formal methods illustrates how the bioinformatics field could benefit from a more systematic approach when dealing with the development and evaluation of ontologies. The understanding of how foundational ontologies are used in bioinformatics can drive future research towards the improvement of ontologies and, consequently, data FAIRness. The adoption of formal methods can impact the quality and sustainability of ontologies, and reusing these methods from other fields is encouraged.
Thermodynamic of moisture vapor sorption and mechanical properties of methylcellulose and ethylcellulose based films to predict its stability
Authors: Velazquez Gonzalo , Guadarrama-Lezama Andrea Y. , Viveros-Contreras Rubi , Diaz-Bandera Daniel , Castaño Johanna 
Published: August 2022

Abstract

The thermodynamic parameters of moisture adsorption isotherms and the mechanical behavior of ethylcellulose (EC) and metylcellulose (MC) polymer-based films were studied. The experimental isotherms were well fitted using the GAB equation with E < 10%. The thermodynamic analysis showed that the minimum integral entropy value was found in the 0.1–0.6 range of water activity (aw) in both types of films, being the lower values for MC. Pore radius values of the films ranged from 0.49 to 352.56 nm, which corresponds to the micropores and mesopores classification. As the moisture content and temperature increased, the pore radius also increased. Compensation enthalpy-entropy in films showed that the water vapor adsorption phenomena was driven by entropy at low aw values. Mechanical analysis of films equilibrated at different aw conditions (0.11–0.90) showed constant values of tensile strength and elongation to break for films at aw values between 0.1 and 0.6, where also the minimum of entropy was reached, confirming that thermodynamic properties could be used to predict the stability of films. The study of thermodynamic water adsorption and the mechanical properties allows understanding the preparation process of stable films with adequate parameters intended for food packaging materials.
A good study about early predictive biomarkers in severe retinopathy of prematurity
Authors: Fu Zhaoqin , Luo Chenghan , Shi Zanyang , Cheng Xinru , Lei Mengyuan , Rong Junbo , Cao Wenjun , Zhang Jingdi , Ge Jian , Ding Wenqian , Song Min , Wang Mengmeng , Zhang Luwen , Ren Miaomiao , Gao Linan , Wang Li , Zhang Qian 
Published: August 2022

Abstract
Objective To explore the evaluation value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cytokines in predicting severe and therapeutic retinopathy of prematurity (ROP).MethodsPremature infants from January 2020 to January 2022 were enrolled in this single-center retrospective study. General characteristics, seven cytokines within 24 hours and NT-proBNP on the 1st, 3rd, 7th and 14th days after birth were collected. Evaluated these risk factors by using univariate Logistic regression and multivariable logistic regression. Receiver operating characteristic curve analysis was used to evaluate the prediction ability. The outcome measures were the occurrence of any stage ROP, severe ROP and therapeutic ROP.Results528 premature infants were involved, 21.4% premature infants (113/528) were diagnosed with ROP, 35.4% (40/113) were diagnosed with severe ROP, 65% (26/40) received intravitreal anti-vascular endothelial growth factor treatment. After adjusting confounding factors, NT-proBNP at day 7 of life (NT-proBNP7) and IL-6 still remained significantly associated with ROP (P < 0.05). For severe ROP, the cut off values for IL-6 and NT-ProBNP7 were respectively 16.28 pg/mL (AUC = 0.830) and 2553ng/L (AUC = 0.846). The AUC value for combining the two indices was 0.919. For therapeutic ROP, the cut off values for IL-6 and NT-ProBNP7 were respectively 18.08 pg/mL (AUC = 0.845) and 4699ng/L (AUC = 0.829). The AUC value for combining the two indices was 0.915.ConclusionsNT-proBNP 7 and IL-6 can be used as early biomarkers for severe and therapeutic ROP. More importantly, two indicators have significantly higher efficacy than individual indicators.
Algebraizations of Propositional Logic And Monadic Logic
Authors: Al-Odhari Adel Mohammed 
Published: August 2022

Abstract

In this paper, we introduce the language systems of propositional logic (LSPL), which involves no variables, and monadic predicate logic(LSMPL), which consists of predicates applied to single variables. We review the validity and dedication related to (LSPL) and (LSMPL) with their properties. After that, we investigate the connection between Boolean algebras with (LSPL) and (LSMPL) to make algebraizations methods out of logic.
Multi-Response Optimization of Skewing Carton Using Taguchi Method with Desirability Function Approach
Authors: Fitria Silfi , Mashuri Muhammad , Ahsan Muhammad 
Published: August 2022

Abstract
Rapid industrial developments have brought the new challenges for quality improvement in industrial competition. Packaging is an integral part of product presentation to attract consumer. Quality and innovation of the packaging are as important as the product itself. One of the quality characteristics of toothpaste carton packaging is skewing, which is measured by the angle and gap skewness of the cardboard. Skewing process optimization is influenced by several factors i.e. glue temperature, glue pressure, height of guide folding, carton varnish concentration, and carton UV intensity. In this research, the angle and gap skewness of the carton is optimized through various set factors experiment. The optimal experimental design is obtained using Taguchi method with desirability function approach. The results show that height of guide folding, glue temperature, and glue pressure contributed significantly to the effect of skewing. The optimum conditions is obtained by applying the 1500C glue temperature setting, 2 bar glue pressure, 8.3 mm guide folding height, 260 Cps carton varnish concentration, and UV intensity with 3 lamps.
Assessment of Preschool Children’s Exposure Levels to Organophosphate and Pyrethroid Pesticide : A Human Biomonitoring Study in Two Turkish Provinces
Authors: GOL Ersin , Cok Ismet , Battal Dilek , Şukuroglu Ayça Aktaş 
Published: August 2022

Abstract
Pesticides are products that were developed for the benefit of humanity. However, now they are one of the critical risk factors threatening the environment, and they create a significant threat to the environmental health of children. Organophosphate (OP) and pyrethroid (PYR) pesticides are widely used in Turkey as well as all over the world. The main focus of this presented study was to analyze the OP and PYR exposure levels in urine samples obtained from 3–6 year old Turkish preschool children who lives in the Ankara (n:132) and Mersin (n:54) provinces. In order to conduct the determination of three non-specific metabolites of PYR insecticides and four non-specific and one specific metabolite of OPs LC-MS/MS quantitative analyses were employed. The non-specific PYR metabolite 3-phenoxybenzoic acid (3-PBA) (87.1%; n = 162) and the specific OP metabolite 3,5,6-Trichloro-2-pyridinol (TCPY) (60.2%; n = 112) were the most frequently detected metabolites in all urine samples. The mean concentrations of 3-PBA and TCPY were 0.38 ± 0.8 and 0.11 ± 0.43 ng/g creatinine, respectively. Although due to the large individual variation no statistically differences were found between 3-PBA (p = 0.9969) and TCPY (p = 0.6558) urine levels in the two provinces, significant exposure differences were determined both between provinces and within the province in terms of gender. Risk assessment strategies performed in light of our findings do not disclose any proof of a possible health problems related to analyzed pesticide exposure in Turkish children.
A Modified Conveyor-belt Algorithm to solve the critical section problem
Authors: Chanda Nilanjan 
Published: August 2022

Abstract
In the domain of Operating System, critical problem and its related concepts play an important role. Process Management is the most vital part for executing various programs required where every process completes for CPU and may use some common variables and changes made to these variables in concurrent processing can produce undesirable results. In this paper, a different type of algorithm is proposed which deals effectively for solving the critical section problem. This algorithm is based on the working of a conveyor belt that a given set of processes shall circulate over the conveyor belt and any process should be able to execute their critical section when it is its turn while the other processes must continue to circulate, waiting for its turn to enter the critical section until all of them are executed.
Nanocrystal-induced Chronic Tubulaonephropathy in Tropical Countries: Diagnosis, Mitigation, and Eradication
Authors: Wimalawansa Sunil J. , Dissanayake Chandra B. 
Published: August 2022

Abstract
In tropical countries, a mysterious tubulointerstitial chronic renal disease (CKD), unrelated to diabetes, hypertension, and immunological causes, manifested over the past four decades. Approximately 25,000 primarily middle-aged male farmers succumb annually to this crystal-tubular nephropathy (CTN). Its cause is hypothesised to arise from agrochemical or heavy metal contamination of food or drinking water. Since no causative factor was identified, this CKD due to crystalline tubular-nephropathy (CKD-CTN) was known as CKD of unknown aetiology (CKDu or CKDmfo). However, current data suggest that it is due to natural causes. Clinical manifestation of CKD-CTN occurs following decades of consumption of high-ionic stagnant groundwater, aided by fluoride. In all affected countries, prolonged annual dry seasons lead to the concentration of ions and minerals in groundwater, making water unpalatable, thus less water consumption. In addition, exposure to hot climatic conditions and daily alcohol intake sustains chronic dehydration. These conditions provide a highly conducive environment—a perfect storm—for calcium phosphate (CaPO4) crystal formation in renal tissues. Recent histological and preliminary electron microscopic data reveal CaPO4 crystals and nano-tubes deposition in kidneys. While CaPO4 nano-minerals are unstable, the presence of fluoride ions stabilises and makes them grow. This new concept paves the path for highly cost-effective, simple solutions to protect peasants and eliminate the disease without embarking on expensive medications or interventions. Chronic dehydration-associated renal crystal formation is preventable by consuming potable water. This straightforward solution of providing drinking water to affected communities prevents chronic dehydration, CKD-CTN-associated renal failure and premature deaths. However, it becomes irreversible once the disease is established beyond CKD stage IIIB. Therefore, eradicating CKD-CTN is through prevention—education and increased water consumption, not by treating end-stage renal disease, expanding dialysis centres and renal transplantation services. The straightforward approaches described here will prevent CKD-CTN and save thousands of lives in affected farming communities.
IMPLEMENTATION OF ACCOUNTING INFORMATION SYSTEM IN BLUD UPT PUSKESMAS PAHANDUT PALANGKA RAYA POST TRANSFER OF STATUS
Authors: Lestari Murdia 
Published: August 2022

Accounting information systems are so important. In services (JasPel) the workforce at BLUD UPT Puskesmas Pahandut still often occurs in calculation errors because there is no latest report on the rank of the workforce itself so that the incentives given are not in accordance with what the workforce should get based on their respective ranks or years of service. respectively. The aims of this study are to (1) describe the application of the cash disbursement cycle for labor services at the BLUD UPT Puskesmas Pahandut Palangka Raya, and to (2) describe the impact of changing the status of the BLUD UPT Puskesmas Pahandut Palangka Raya from UPTD to BLUD on the expenditure cycle.
This research is a field research, with a descriptive approach. The method used in this study is a qualitative method. The subjects in this study were the Head of the TU (KASUBAG TU), the BLUD Expenditure Treasurer, financial staff other contract personnel. The data collection techniques were observation, interviews, and documentation which were then analyzed using data collection techniques, data reduction, data presentation, and drawing conclusions.
The result of this research is that the BLUD UPT Puskesmas Pahandut has been able to implement an accounting information system quite well during the status transition. It's just that there are obstacles that often occur and can lead to calculation errors. The impact of the change in status led to adjustments from the puskesmas and their workforce, decreased service incentive income, and the source of funds came from BLUD revenues.

Keywords: Implementation; BLUD; Transfer Status