bluuebunny/crossref_metadata_2025_split huggingface dataset:
Museum Genomics Provide Evidence for Persistent Genetic Differentiation in a Threatened Seabird Species in the Western Atlantic
Authors: Byerly Paige A , Chesser R Terry , Fleischer Robert C , McInerney Nancy , Przelomska Natalia A S , Leberg Paul L 
Published: July 2022

Abstract
Connectivity among wildlife populations facilitates exchange of genetic material between groups. Changes to historical connectivity patterns resulting from anthropogenic activities can therefore have negative consequences for genetic diversity, particularly for small or isolated populations. DNA obtained from museum specimens can enable direct comparison of temporal changes in connectivity among populations, which can aid in conservation planning and contribute to the understanding of population declines. However, museum DNA can be degraded and only available in low quantities, rendering it challenging for use in population genomic analyses. Applications of genomic methodologies such as targeted sequencing address this issue by enabling capture of shared variable sites, increasing quantity and quality of recovered genomic information. We used targeted sequencing of ultra-conserved Elements (UCEs) to evaluate potential changes in connectivity and genetic diversity of roseate terns (Sterna dougallii) with a breeding distribution in the northwestern Atlantic and the Caribbean. Both populations experienced range contractions and population declines due to anthropogenic activity in the 20th century, which has the potential to alter historical connectivity regimes. Instead, we found that the two populations were differentiated historically as well as contemporaneously, with little evidence of migration between them for either time period. We also found no evidence for temporal changes in genetic diversity, although these interpretations may have been limited due to sequencing artifacts caused by the degraded nature of the museum samples. Population structuring in migratory seabirds is typically reflective of low rates of divergence and high connectivity among geographically segregated subpopulations. Our contrasting results suggest the potential presence of ecological mechanisms driving population differentiation, and highlight the value of targeted sequencing on DNA derived from museum specimens to uncover long-term patterns of genetic differentiation in wildlife populations.
Ultrastructural examination of mouse kidney glomerular capillary loop by sandwich freezing and freeze-substitution
Authors: Yamaguchi Masashi , Takahashi-Nakaguchi Azusa , Uematsu Katsuyuki , Yamada Hiroyuki , Sato-Okamoto Michiyo , Chibana Hiroji 
Published: July 2022

Abstract
Sandwich freezing is a method of rapid freezing by sandwiching specimens between two metal disks and has been used for observing exquisite the close-to-native ultrastructure of living yeast and bacteria. Recently, this method has been found to be useful for preserving cell images of glutaraldehyde-fixed animal and human tissues. In the present study, this method was applied to observe the fine structure of mouse glomerular capillary loops. Morphometry was then performed, and the results were compared with the data obtained by an in vivo cryotechnique, which may provide the closest ultrastructure to the native state of living tissue. The results show that the ultrastructure of glomerular capillary loops obtained by sandwich freezing–freeze-substitution after glutaraldehyde fixation was close to that of the ultrastructure obtained by in vivo cryotechnique not only in the quality of cell image but also in quantitative morphometry. They indicate that the ultrastructure obtained by sandwich freezing–freeze-substitution after glutaraldehyde fixation may more closely reflect the living state of cells and tissues than conventional chemical fixation and dehydration at room temperature and conventional rapid freezing–freeze-substitution of excised tissues without glutaraldehyde fixation. Sandwich freezing–freeze-substitution techniques should be used routinely as a standard method for observing the close-to-native ultrastructure of biological specimens.
Apolipoprotein E ε4 Mediates Myelin Breakdown by Targeting Oligodendrocytes in Sporadic Alzheimer Disease
Authors: Cheng Gerald Wai-Yeung , Mok Kingston King-Shi , Yeung Sunny Hoi-Sang , Kofler Julia , Herrup Karl , Tse Kai-Hei 
Published: July 2022

Abstract
White matter degradation in the frontal lobe is one of the earliest detectable changes in aging and Alzheimer disease. The ε4 allele of apolipoprotein E (APOE4) is strongly associated with such myelin pathology but the underlying cellular mechanisms remain obscure. We hypothesized that, as a lipid transporter, APOE4 directly triggers pathology in the cholesterol-rich myelin sheath independent of AD pathology. To test this, we performed immunohistochemistry on brain tissues from healthy controls, sporadic, and familial Alzheimer disease subjects. While myelin basic protein expression was largely unchanged, in frontal cortex the number of oligodendrocytes (OLs) was significantly reduced in APOE4 brains independent of their Braak stage or NIA-RI criteria. This high vulnerability of OLs was confirmed in humanized APOE3 or APOE4 transgenic mice. A gradual decline of OL numbers was found in the aging brain without associated neuronal loss. Importantly, the application of lipidated human APOE4, but not APOE3, proteins significantly reduced the formation of myelinating OL in primary cell culture derived from Apoe-knockout mice, especially in cholesterol-depleted conditions. Our findings suggest that the disruption of myelination in APOE4 carriers may represent a direct OL pathology, rather than an indirect consequence of amyloid plaque formation or neuronal loss.
Secondary Syphilis Presentation and Urticarial Eruption After Moderna COVID-19 Vaccination
Authors: Brockshus Aaron , Evans Martin O , Punch Chandra 
Published: July 2022

ABSTRACT
The diversity of the cutaneous manifestations of syphilis and the ability of the spirochete to evade diagnosis have been well documented by medical literature. However, what triggers the onset of secondary syphilis is not yet clear because of difficulties studying the bacterium. Our case describes the onset of a heterogeneous rash (or coexisting rashes) that presented the day after vaccination with the Moderna mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. The potential etiologies of the patient’s rash: A vaccine reaction, reactivation of chronic spontaneous urticaria, or a physical sign of syphilis itself are then reviewed. The potential for the Moderna coronavirus disease 2019 (COVID-19) vaccine to be the catalyst of this patient’s cutaneous manifestations of his immune system responses is also hypothesized.
From Ancient to Modern: Identifying Anglicanism in an Anglo-Jewish Hymnal
Authors: Padley Danielle 
Published: July 2022

ABSTRACT
In 1899, Francis L. Cohen and David M. Davis published Kol Rinnah U’Tefillah: The Voice of Prayer and Praise. This pioneering ‘Handbook of Synagogue Music for Congregational Singing’ standardized the body of liturgical music used in Anglo-Jewish worship to this day. Early references to the volume as a ‘hymnal’ highlight parallels with Anglican music publications of the period, notably Hymns, Ancient and Modern (1861), the unofficial hymnbook of the Church of England. Published over thirty years apart, there are nonetheless striking correlations between the purpose, reception, and content of the two collections. This article explores these correlations, tracing the histories of Hymns Ancient and Modern and The Voice of Prayer and Praise in relation to two other prominent volumes published in mid-century: John Mason Neale and Thomas Helmore’s Hymnal Noted (1851) and Emanuel Aguilar and David Aaron De Sola’s The Ancient Melodies of the Spanish and Portuguese Jews (1857).
Physical properties of near-Earth asteroid (2102) Tantalus from multiwavelength observations
Authors: Rożek Agata , Lowry Stephen C , Rozitis Benjamin , Dover Lord R , Taylor Patrick A , Virkki Anne , Green Simon F , Snodgrass Colin , Fitzsimmons Alan , Campbell-White Justyn , Sajadian Sedighe , Bozza Valerio , Burgdorf Martin J , Dominik Martin , Figuera Jaimes R , Hinse Tobias C , Hundertmark Markus , Jørgensen Uffe G , Longa-Peña Penélope , Rabus Markus , Rahvar Sohrab , Skottfelt Jesper , Southworth John 
Published: July 2022

ABSTRACT
Between 2010 and 2017, we have collected new optical and radar observations of the potentially hazardous asteroid (2102) Tantalus from the ESO NTT and Danish telescopes at the La Silla Observatory, and from the Arecibo planetary radar. The object appears to be nearly spherical, showing a low-amplitude light-curve variation and limited large-scale features in the radar images. The spin-state is difficult to constrain with the available data; including a certain light-curve subset significantly changes the spin-state estimates, and the uncertainties on period determination are significant. Constraining any change in rotation rate was not possible, despite decades of observations. The convex light curve-inversion model, with rotational pole at λ = 210° ± 41° and β = −30° ± 35°, is more flattened than the two models reconstructed by including radar observations: with prograde (λ = 36° ± 23°, β = 30° ± 15°), and with retrograde rotation mode (λ = 180° ± 24°, β = −30 ± 16°). Using data from WISE, we were able to determine that the prograde model produces the best agreement in size determination between radar and thermophysical modelling. Radar measurements indicate possible variation in surface properties, suggesting one side might have lower radar albedo and be rougher at the centimetre-to-decimetre scale than the other. However, further observations are needed to confirm this. Thermophysical analysis indicates a surface covered in fine-grained regolith, consistent with radar albedo, and polarisation ratio measurements. Finally, geophysical investigation of the spin-stability of Tantalus shows that it could be exceeding its critical spin-rate via cohesive forces.
Bayesian control variates for optimal covariance estimation with pairs of simulations and surrogates
Authors: Chartier Nicolas , Wandelt Benjamin D 
Published: July 2022

ABSTRACTPredictions of the mean and covariance matrix of summary statistics are critical for confronting cosmological theories with observations, not least for likelihood approximations and parameter inference. Accurate estimates require running costly N-body and hydrodynamics simulations. Approximate solvers, or surrogates, greatly reduce the computational cost but introduce biases, especially in the non-linear regime of structure growth. We propose ‘CARPool Bayes’ to solve the inference problem for both the means and covariances using a combination of simulations and surrogates. Our approach allows incorporating prior information for the mean and covariance. We derive closed-form solutions for maximum a posteriori covariance estimates that are efficient Bayesian shrinkage estimators, guarantee positive semidefiniteness, and can optionally leverage analytical covariance approximations. We discuss choices of the prior and propose a procedure for obtaining optimal prior hyperparameter values with a small set of test simulations. We test our method by estimating the covariances of clustering statistics of gadget-iiiN-body simulations at redshift z = 0.5 using surrogates from a 100–1000× faster particle-mesh code. Taking the sample covariance from 15 000 simulations as the truth, and using an empirical Bayes prior with diagonal blocks, our estimator produces nearly identical Fisher matrix contours for ΛCDM parameters using only 15 simulations of the non-linear dark matter power spectrum. In this case, the number of simulations is so small that the sample covariance is degenerate. We show cases where even with a naïve prior our method improves the estimate. Our framework is applicable to a wide range of cosmological problems where fast surrogates are available.
2001 SN263 – the contribution of their irregular shapes on the neighbourhood dynamics
Authors: Valvano G , Winter O C , Sfair R , Machado Oliveira R , Borderes-Motta G 
Published: July 2022

ABSTRACT
The first proposed Brazilian mission to deep space, the ASTER mission, has the triple asteroid system (153591) 2001 SN263 as a target. One of the mission’s main goals is to analyse the physical and dynamical structures of the system to understand its origin and evolution. This work aims to analyse how the asteroid’s irregular shape interferes with the stability around the system. The results show that the irregular shape of the bodies plays an important role in the dynamics nearby the system. For instance, the perturbation due to the (153591) 2001 SN263 Alpha’s shape affects the stability in the (153591) 2001 SN263 Gamma’s vicinity. Similarly, the (153591) 2001 SN263 Beta’s irregularity causes a significant instability in its nearby environment. As expected, the prograde case is the most unstable, while the retrograde scenario presents more stability. Additionally, we investigate how the solar radiation pressure perturbs particles of different sizes orbiting the triple system. We found that particles with a 10–50 cm radius could survive the radiation pressure for the retrograde case. Meanwhile, to resist solar radiation, the particles in prograde orbit must be larger than the particles in retrograde orbits, at least one order of magnitude.
WS-Snapshot: an effective algorithm for wide-field and large-scale imaging
Authors: Xie Yang-Fan , Wang Feng , Deng Hui , Mei Ying , Lü Ying-He Celeste , Hodosán Gabriella , Stolyarov Vladislav , Smirnov Oleg , Li Xiao-Feng , Cornwell Tim 
Published: July 2022

ABSTRACT
The Square Kilometre Array (SKA) is the largest radio interferometer under construction in the world. The high accuracy, wide-field, and large size imaging significantly challenge the construction of the Science Data Processor (SDP) of SKA. We propose a hybrid imaging method based on improved W-Stacking and snapshots. The w-range is reduced by fitting the snapshot uv plane, thus effectively enhancing the performance of the improved W-Stacking algorithm. We present a detailed implementation of WS-Snapshot. With full-scale SKA1-LOW simulations, we present the imaging performance and imaging quality results for different parameter cases. The results show that the WS-Snapshot method enables more efficient distributed processing and significantly reduces the computational time overhead within an acceptable accuracy range, which would be crucial for subsequent SKA science studies.
Prevalence and risk factors of monoclonal gammopathy in patients with autoimmune inflammatory rheumatic disease: A systematic review and meta-analysis
Authors: Bai Zhiqian , Hu Chuanyu , Zhong Jixin , Dong Lingli 
Published: July 2022

ABSTRACTObjectiveTo systemically investigate the prevalence and risk factors of monoclonal gammopathy (MG) in patients with autoimmune inflammatory rheumatic disease (AIIRD).MethodsA literature search was conducted using databases of PubMed, EMBASE, and Web of Science for relevant studies from inception to 31 July 2021. The pooled prevalence, odds ratio (OR), weighted mean difference (WMD), and 95% confidence interval (CI) were calculated with Stata 16.0 using a random or fixed effects model.ResultsIn 17 included studies involving 6667 AIIRD patients, the pooled prevalence of MG in AIIRD patients was 7% (95%CI: 0.06–0.09). Compared to general populations, patients with Sjögren’s syndrome (SS) possessed the highest risk for MG (OR 4.51; 95%CI: 3.39–5.74), followed by systemic lupus erythematosus (OR 3.99; 95%CI: 2.84–5.14), ankylosing spondylitis (OR 2.04; 95%CI: 1.11–2.97), and rheumatoid arthritis (OR 2.00; 95%CI: 1.79–2.22). Older age (WMD = 5.17 years; 95%CI: 0.68–9.66), higher erythrocyte sedimentation rate (WMD = 14.04 mm/H; 95%CI: 7.77–20.30), higher serum gammaglobulins level (WMD = 1.92 mg/dl, 95%CI: 0.51–3.32) were associated with a greater risk of MG in AIIRD patients.ConclusionsMG prevalence was higher in AIIRD patients, especially in SS patients. Older age, higher erythrocyte sedimentation rate, and hypergammaglobulins were risk factors for MG in AIIRD patients.
A Cross-sectional Analysis of Socio-spatial Patterning of Tobacco Retail in Shanghai, China
Authors: Zheng Chunyu , Feng Zhiqiang , Pearce Jamie 
Published: July 2022

Abstract

Introduction
International evidence from high-income countries demonstrates that the availability of tobacco tends to be greater in more urban and more deprived neighborhoods. However, little is known about the socio-spatial disparities in other settings, including megacities in China. This study investigated the patterning of tobacco retailers across Shanghai by types of tobacco retailers, including the relationship with levels of urbanity and neighborhood deprivation.

Aims and Methods
Tobacco retailer data (n = 19 413) was extracted from a web-scraped Points-of-Interest database. For all communities (n = 5432) across Shanghai, neighborhood tobacco retail availability was calculated using population-weighted kernel density estimation and grouped by quintiles of neighborhood deprivation and a 3-level urban classification. Associations were analyzed using the Kruskal–Wallis tests and epsilon squared.

Results
Across Shanghai, tobacco retail availability decreased from more urbanized areas to less urbanized areas. There was a statistical difference (p &lt; .001) in the availability of tobacco retail across quintiles of deprivation, with the highest availability in the less deprived neighborhoods, and the lowest availability in the most deprived neighborhoods. However, this trend was reversed in the urban center, where retail availability was greatest in the most deprived areas. Convenience stores were the most common type of tobacco retailer across the city, while tobacco-only outlets were most strongly associated with levels of neighborhood deprivation.

Conclusions
The results show an association between tobacco retail availability and neighborhood deprivation, which varied with levels of urbanity and types of tobacco retailers. These findings provide supportive evidence for further interventions that target reducing inequalities in exposure to tobacco retail.

Implications
This is the first study to examine the relationship between tobacco retail availability and neighborhood deprivation in the context of Chinese megacities. Using data from Shanghai, China, we found a significant non-linear association between tobacco retail availability and neighborhood deprivation across the city. It is plausible that the socio-spatial disparities in tobacco retail availability at the neighborhood level may be a key factor explaining differences in smoking behaviors between sociodemographic groups. The findings emphasize the need for greater efforts in regulating neighborhood-level tobacco retailing in China.
ROP Interactive Partners are Involved in the Control of Cell Division Patterns in Arabidopsis Leaves
Authors: Hasi Qimuge , Kakimoto Tatsuo 
Published: July 2022

Abstract
Animal Rho GTP-binding proteins and their plant counterparts, Rho of plants (ROPs), regulate cell polarity, but they do so through different effector proteins. A class of ROP effectors, interactor of constitutive active ROPs (ICRs)/ROP interactive partners (RIPs), has been implicated in diverse biological processes; however, there are limited analyses of RIP loss-of-function mutants. Here, we report an analysis of the functions of the Arabidopsis thaliana RIPs in the leaf epidermis. Green Fluorescent Protein (GFP) fusion proteins of all the RIPs colocalized to cortical microtubules. RIP1, RIP3 and RIP4, but not RIP2 and RIP5, colocalized with the preprophase band (PPB), spindles and phragmoplasts. RIP2 and RIP5 did not colocalize with the PPB, spindles or phragmoplasts even when they were expressed under a promoter active in proliferative cells, indicating that there are differences among RIP protein properties. The overexpression of RIP1 or RIP4 resulted in the fragmentation of cortical microtubules, and the rip1 2 3 4 5 quintuple mutant showed increased growth rate of microtubules at their plus ends compared with the wild type. The rip1 2 3 4 5 mutant leaves and petals were narrow, which was explained by the decreased cell number along the transverse axis compared with that of the wild type. The rip1 2 3 4 5 mutant leaf epidermis possessed fewer PPBs oriented close to the long axis of the leaf compared with wild type, indicating the involvement of RIPs in cell division plane regulation and leaf shape determination.
Impact of Personalized Outcomes Forecasts on Clinical Reasoning of Physical Therapists in Intermittent Claudication: A Vignette Study
Authors: Sinnige Anneroos , Teijink Joep A W , Spruijt Steffie , Kittelson Andrew J , Oude Bos Anita , Van der Wees Philip J , Hoogeboom Thomas J 
Published: July 2022

Abstract

Objective
Guidelines recommend supervised exercise therapy and lifestyle counseling by a physical therapist as initial treatment for patients with intermittent claudication. However, guidelines provide only a crude estimate of the outcomes that therapists and patients might expect from treatment. The purpose of this study was to explore the impact of personalized outcomes forecasts (POFs) on the decision-making process of physical therapists and to learn lessons on facilitating the use of forecasts in daily practice.

Methods
A vignette-based, think-aloud interview study design was used. The participants were physical therapists trained in treating patients with intermittent claudication. Vignettes described fictitious patients diagnosed with intermittent claudication and included POFs. A directed approach was used to code, organize, and describe the data. Transcripts were analyzed using a thematic approach.

Results
Sixteen therapists participated in the study. Three themes were identified: (1) setting and contextualizing treatment expectations, (2) setting (shared) goals and (de)motivating the patient, and (3) establishing and monitoring the treatment plan. Therapists mentioned that POFs could be useful for setting expectations and realistic treatment goals, contextualizing expected treatment response, stimulating patients to achieve their goals, and deciding on treatment frequency and treatment timing. Therapists thought POFs would be of less use for changing treatment goals during follow-up visits or for establishing intensity or type of training.

Conclusion
To overcome challenges that may arise when adopting POFs in daily practice, adequate training of physical therapists should be conducted. Potential areas to address with training include statistical and data literacy as well as guidance on integrating POFs with existing treatment protocols.

Impact
The use of POFs by physical therapists might contribute to a more person-centered care approach. The insights provided by this study on the first use of POFs by physical therapists can serve as an example and lesson on how to optimally implement such supporting tools into daily practice.