bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender Differences in 10-Year Mortality in Patients with Coronary Artery Disease with Elevated Lipoprotein(a): In Search of Invisible Guardian Angel
Authors: Shek Aleksandr B , Alieva Rano B , Abdullaev Alisher A , Fozilov Khurshid G , Khoshimov Shavkat U , Bekmetova Feruza M , Nizamov Ulugbek I , Ziyaeva Adolat V 
Published: June 2022

The objective of our study was to examine the contribution of elevated Lp(a) to 10-year mortality in 140 CAD patients, depending on gender, baseline lipid levels, ApoA-I, ApoB, and the ApoA1, ApoE, and ApoB gene polymorphisms.	Methods and Results: The study included 140 patients (75 men and 65 women) of the Uzbek population, hospitalized with diagnosis “CAD, unstable angina (IIB class, E. Braunwald et al., 1989)” (main group) in the period between January 2009 and February 2011. The endpoints at 10-year follow-up were death from cardiovascular causes (fatal myocardial infarction and sudden cardiac death). In the studied cohort of CAD patients, Lp(a) distribution was skewed to the right, the median was 16.9mg/dL, and the mean was 34.3mg/dL. At the same time, Lp(a) value greater than the 75th percentile was >41mg/dL. In this regard, we compared the baseline values in 2 groups of patients: Group 1 (Lp(a)<41mg/dL) and Group 2 (Lp(a)>41mg/dL).	The 10-year cardiovascular mortality rate was higher significantly in Group 2 (RR =3.67; 95% CI: 1.67-8.11; P=0.0013). Cardiovascular mortality was significantly higher (P<0.001) in men of Group 2 than in men of Group 1 (RR=5.31; 95% CI: 2.03-13.88; P<0.001), while in women, the 10-year mortality in the compared groups did not differ significantly. Cardiovascular mortality was lower in patients with ApoA-1≥140mg/dL, the majority of whom were women.	Conclusion: In the absence of targeted Lp(a) therapy, long exposure to a level of Lp(a) of >41mg/dL is a factor that increases 10-year mortality in CAD patients. Highlights •	10-year cardiovascular mortality was higher in CAD patients with Lp(a)>41mg/dL. •	However, the increase in mortality due to high Lp(a) was statistically significant in men than in women. •	The ApoA-I level was higher in women than in men. •	Cardiovascular mortality was lower in patients with ApoA-I≥140mg/dL, most of whom were women.
Experimental Evaluation of Hemostatic Agents and Powdered Sorbent Effectiveness on the Dynamics of Blood Aggregate State Regulation using the Method of Thromboelastography
Authors: Vorontsov Alexey K , Parkhisenko Yuri A , Cherednikov Evgeniy F , Barannikov Sergey V , Mehantjeva Ludmila E , Yuzefovich Igor S , Bezaltynnykh Alexander A , Ovsyannikov Evgeniy S 
Published: June 2022

Background: This article presents the results of an experimental study on the effect of hemostatic agents (Hemostatic collagen sponge, Tachocomb, Surgitamp and granular sorbent Molselect G-50) on the system regulating the aggregate state of the blood (SRASB) using piezoelectric thromboelastography (TEG). Methods and Results: The study involved 18 healthy men aged between 21 and 43 years [29.0 (25.0-32.5) years] with normal indicators of the SRASB. In the first series of experiments, TEG of the blood was recorded without the addition of the test material (the control stage). At the second stage of the experiment, the hemostatic properties of the Hemostatic collagen sponge, Tachocomb, hemostatic gauze Surgitamp and granular sorbent Molselect G-50 were studied.	In vitro experimental studies to assess the effect of hemostatic agents and granular sorbent on the SRASB using piezoelectric TEG have shown that the use of Hemostatic collagen sponge, Tachocomb, Surgitamp, and the granular sorbent Molselect G-50 convincingly affects all links of the thrombosis process. However, Surgitamp and the granular sorbent Molselect G-50 show the greatest influence on such important indicators as TBC and MCD, which gives reason to conclude they are effective in clinical use in surgical practice.
Features in the Processes of Left Ventricular Remodeling Depending on the Degree of Renal Dysfunction in Patients with Chronic Heart Failure
Authors: Kamilova Umida , Atakhodjaeva Gulchekhra , Abdullaeva Charos , Masharipova Dilyafruz , Zakirova Gulnoza , Tagaeva Dilnoza 
Published: June 2022

Background: The aim of this research was to study the features of changes in the parameters of heart remodeling in patients with coronary heart disease (CHD) and chronic heart failure (CHF), depending on the degree of renal dysfunction (RD).	Methods and Results: The study included 150 CHD patients with NYHA functional class (FC) I-IIII of CHF. All examined patients were subdivided according to the level of eGFR: Group A included 81 patients with CHF FCI-III and eGFRCKD-EPI>60 mL/min per 1.73m2; Group B included 69 patients with CHF FCI-III and eGFRCKD-EPI≤60 mL/min per 1.73m2. It was found an increase in left ventricular (LV) mass in Group B by 11.4%, compared to Group A (P=0.000). Analysis of LV systolic function showed that in Group B, values of LF ejection fraction and fractional shortening were significantly lower than in Group A (47.64±0.61% vs. 52.7±0.28%, and 25.40±0.46% vs. 28.23±0.25%, respectively, P=0.000). Thus, in Group B, we found CHFrEF, compared to Group A with CHFpEF. Analysis of diastolic function revealed that in Group B, the E/A ratio was statistically higher than in Group A (1.12±0.05 vs. 0.81±0.04, respectively, P=0.000). At the same time, in Group B, values of IVRT and DT were significantly lower than in Group A (85.01±0.8 ms vs. 91.25±0.99 ms, and 177.8±2.1 ms vs. 197.5±2.07 ms, respectively, P=0.000). Thus, the signs of the impaired relaxation (Grade 1 DD) and the pseudonormal filling pattern (Grade 2 DD) were found in Group A and Group B, respectively.	Conclusion: RD in patients with CHF is an important factor in the significant deterioration of LV systolic and diastolic functions.
Lipids Peroxidation Products in Young Men with Type 1 Diabetes Mellitus
Authors: Darenskaya Marina A , Chugunova Elena V , Kolesnikov Sergey I , Semenova Natalya V , Kolesnikova Lyubov I 
Published: June 2022

The aim of this research was to assess the level of lipid oxidation products level and the antioxidant defense state in young male patients with type 1 diabetes mellitus (T1DM) depending on the disease duration.	Materials and Methods: A total of 57 men of young reproductive age (average age of 30.25±8.51 years) with T1DM and an unsatisfactory glycemic profile, depending on the disease duration, were divided into 2 groups. Group 1 included 29 men (average age of 27.69±6.92 years) with a T1DM duration <5 years (2.72±1.61 years) and HbA1c level of 11.37±2.74%. Group 2 included 28 men (average age of 32.89±9.28 years) with a T1DM duration ≥5 years (12.93±5.69) and HbA1c level of 10.19±2.18%). The control group consisted of 28 men of the same age (29.71±4.59 years). Spectrophotometric/spectrofluorometric methods and enzyme immunoassay were used.	Results: We found a significant increase in the values of CDs (by 2.04 times, P<0.0001), KD and CT (by 2.38 times, P<0.0001), TBARs (by 1.17 times, P=0.001), SB (by 2.6 times, P<0.0001), and retinol (by 1.44 times, P<0.0001) in Group 1 compared to the control group. In Group 2, there was a statistically significant increase in the levels of CDs (by 2.59 times, P<0.0001), KD and CT (by 2.94 times, P<0.0001), TBARs (by 1.49 times, P=0.001), SB (by 3.27 times, P<0.0001), and retinol (by 1.4 times, P=0.001) compared to the control group. The differences between the two groups with different duration of T1DM were characterized only by the CDs level, which was increased in Group 2 patients with a T1DM duration of ≥5 years (by 1.27 times, P=0.048) compared to Group 1 patients with a T1DM duration of < 5 years.	Conclusion: LPO parameters can serve as additional laboratory markers that characterize the course of T1DM and can be used to develop potential prevention and therapy strategies.
The acceptability of cervical electrical impedance spectroscopy: A mixed methods study examining women’s experiences of a novel test to predict preterm birth
Authors: Stern Victoria , Jones Georgina , Senbeto Sarah , Anumba Dilly 
Published: June 2022

Abstract
Background
Reducing the rate of preterm birth is a cornerstone of global efforts to address child mortality. Existing tests offer imperfect prediction, particularly for universal screening. Cervical electrical impedance spectroscopy (EIS) is a novel technique to quantify the ripening changes which precede labour. Mid-trimester EIS measurements have been shown to accurately predict preterm birth in asymptomatic women. This study aimed to comprehensively evaluate the acceptability of cervical EIS to low and high-risk women undergoing screening during a larger prospective trial.
Methods
In this parallel convergent mixed methods study, 40 women completed questionnaires before and after screening tests (EIS, cervical length measurement and fetal fibronectin quantification). Quantitative outcomes were anxiety levels before and after screening (Spielberger State Trait Anxiety Inventory, STAI-6), pain (Short Form McGill Pain Questionnaire) and ratings of EIS device appearance and test acceptability (visual analogue scales). Twenty-one women (11 high-risk, 10 low-risk) also attended a semi-structured qualitative interview. Interviews were recorded and transcribed, then thematic analysis was performed. A convergence coding matrix was constructed to enable triangulation of quantitative and qualitative results.
Results
High risk women demonstrated a significant reduction in anxiety following screening (mean STAI-6 score 34.5 vs. 29.0, p = 0.002). A similar trend was observed among low-risk participants. Ratings of pain, EIS device appearance and procedural acceptability did not differ between groups. Mean pain ratings were low (visual analogue scale 0.97 and 1.01), comparing favourably to published evaluations of conventional screening tests. Qualitative analysis provided insight into both the physical consequences and emotional experiences of screening. Additional determinants of the screening experience included device design, pre-existing perspectives on intimate examination, attitudes to knowledge in pregnancy and interaction with clinical staff. Finally, a range of practical considerations regarding wider use of EIS were identified, with valuable complementary detail regarding acceptability for use in antenatal care.
Conclusions
Cervical EIS is well tolerated and acceptable to both low and high-risk women. These results provide useful insights to inform the design of future study and screening protocols
Te Waikoropupu Springs and the Arthur Marble Aquifer, New Zealand: flow contributions and nitrate sources
Authors: Williams Paul W. 
Published: June 2022

Abstract
This paper investigates sources of early signs of nitrate pollution in a major karst spring. Te Waikoropupu Springs are the largest springs in New Zealand and amongst the largest in the Southern Hemisphere with a mean outflow of 13.4 m3/s. They discharge the clearest water ever recorded from a karst spring, but early warning of water quality deterioration is signalled by increasing nitrate concentrations. The springs discharge water from a partly artesian reservoir of 2.85 km3 volume in karstified Ordovician marble with a transmission time averaging 7.9 years. Reservoir porosity is unusually high for a crystalline carbonate rock, estimated as 5-7%. Water emerging at Main Spring and adjacent Fish Creek Springs is a mix of recharge from four main sources. The paper investigates by means of mass balance modelling the proportions of water coming from each source and the origins of nitrate contamination. Water losses into the bed of the upper Takaka River, about 17 km from the Springs, provide 19% of mean flow at Main Spring, 36% of flow at Fish Creek Springs, and 81% of the volume discharged at submarine springs. Rain falling over farmed land in the central valley is estimated to contribute 8.4% of total outflow at Main Spring and Fish Creek Springs but to carry 85% of the NO3 -N output discharged at the springs. A 34% reduction of leachate concentration in the central valley would be required to bring NO3-N values at Main Spring back to levels recorded in the 1970s.
LMI Based Synchronization Control of Nonlinear Affine Fractional Order Chaotic Systems Considering Input Constraint
Authors: Soleimanizadeh Ali , Nekoui Mohammad Ali , Shoorehdeli Mahdi Aliyari 
Published: June 2022

Abstract
This paper deals with synchronization problem of chaotic nonlinear fractional order systems with input saturation constraint. To develop the idea, at first a generlized sector condition and a memory-less nonlinear function are employed to deal with the saturation problem. Then a new state feedback controller is designed to achieve synchronization in master-slave chaotic fractional order nonlinear systems with input saturation. The stability of the closed-loop system is guaranteed using Lyapunov theory and sufficient stability conditions are formulated in terms of caputo fractional derivative of a quadratic Lyapunov function and Linear Matrix Inequalities (LMI) . Finally, to verify the effectiveness of the proposed control scheme, some simulation results are employed to show the effectiveness of the proposed methodology.
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis
Authors: Tamai Minori , Fujisawa Shinichi , Nguyen Thao , Komatsu Chiaki , Kagami Keiko , Kamimoto Kenji , Omachi Kohei , Kasai Shin , Harama Daisuke , Watanabe Atsushi , Akahane Koshi , Goi Kumiko , Naka Kazuhito , Kaname Tadashi , Teshima Takanori , Inukai Takeshi 
Published: June 2022

Abstract
The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 gene located on chromosome 22q11. Thus, mimicking the initiation process of translocation, we induced CRISPR/Cas9-mediated DSBs simultaneously at the breakpoints of the BCR and ABL1 genes in a granulocyte-macrophage colony-stimulating factor (GM-CSF) dependent human leukemia cell line. After transfection of two single guide RNAs (sgRNAs) targeting intron 13 of the BCR gene and intron 1 of the ABL1 gene, a factor-independent subline was obtained. In the subline, p210 BCR::ABL1 and its reciprocal ABL1::BCR fusions were generated as a result of balanced translocation corresponding to the Ph chromosome. Another set of sgRNAs targeting intron 1 of the BCR gene and intron 1 of the ABL1 gene induced a factor-independent subline expressing p190 BCR::ABL1. Both p210 and p190 BCR::ABL1 induced factor-independent growth by constitutively activating intracellular signaling pathways for transcriptional regulation of cell cycle progression and cell survival that are usually regulated by GM-CSF. These observations suggested that simultaneous DSBs at the BCR and ABL1 gene breakpoints are initiation events for oncogenesis in Ph + leukemia. (200/200 words)
A Novel Hybrid SDR-Regression based Early Termination Processes for the Fully Parallel Turbo Decoder for LTE
Authors: Beeharry Yogesh 
Published: June 2022

Abstract
The fully parallel Turbo decoder has been developed in view to meet the requirements for next generation telecommunication systems. Given the slight increase in computational complexity as compared to the conventional serial decoder, there is still the need to fill this gap. As such, this paper presents early termination processes for the fully parallel Turbo decoder. The results demonstrate a slight degradation in error performance with the proposed hybrid scheme as compared to the conventional stand-alone early stopping mechanisms. The degradation in BER is around 0.5 dB on average below a BER of 10− 3 when a block length of 3072 is considered. For a block length of 6144, the degradation is less than 0.2 dB on average below a BER of 10− 1. Interestingly, the degradation in error performance decreases with increasing block length. Results for average number of decoding iterations reveal that the proposed scheme inherits the performance trends of both SDR and regression analysis based early stopping schemes. Additionally, the number of iterations for the hybrid scheme is lower than both conventional schemes throughout the full Eb/N0 region simulated. When considering a block length of 3072 and the Eb/N0 value of 2.0 dB, the proposed scheme uses 16 and 3 iterations less than the regression analysis and SDR based early stopping mechanisms respectively. In the case of a block length of 6144 and the Eb/N0 value of 2.0 dB, the proposed scheme uses 13 and 2 iterations less than the regression analysis and SDR based early stopping mechanisms respectively.
Post Occupancy Evaluation of Housing Reconstruction After Cyclone Sidr
Authors: Kamruzzaman Md. , Harun-Or-Rashid G. M. , Chakrabartty Mithun , Castro Juan Jose 
Published: June 2022

Abstract
Post occupancy evaluation of housing reconstruction after a disaster is imperative for every nation that pushes ahead the idea of resilient housing, which is obligatory for the social, cultural, and economic growth of a society or a country. Cyclone SIDR is the most dreadful of all catastrophes that have struck Bangladesh and aftermath of this catastrophe, a number of donor organizations stepped up to help victims by providing housing solutions. The aim of this study is to effectiveness analysis of the housing reconstruction programs from planning and construction standpoints with a post occupancy framework. Based on three months of detailed field survey at the mostly devastated location of cyclone SIDR, Southkhali Union (small rural area) of Sarankhola Upazila (sub-district) of Bagerhat District, this research infers that the donor organizations didn’t pay much attention in terms of choice, need and decision-making role to provide reconstructed houses for the target beneficiaries. The study found that about 78% of the reconstructed houses hold dissatisfaction of the beneficiaries. As a result, people prompt to transform or modify 54% of the ‘Donor Driven’ houses according to their choice and need soon after completion of the project. Another 16% donor driven house remained abandoned and rest 8% demolished. On the other hand, owner driven houses are functionally perfect, affordable, use locally available natural materials with resilient planning and construction features which reduces disaster vulnerability and sustains for long time in comparison with donor driven houses.
The role of domain size and the weight ratio of fullerene and non-fullerene acceptors on performance of PM6:Y6: PCBM ternary solar cell.
Authors: Piralaee Mina , Asgari Asghar 
Published: June 2022

Abstract
Recently, ternary solar cells have developed as a vital photovoltaic-technology since they combine the advantages of both single junction and tandem solar cells with their processing simplicity, mechanical flexibility, and lightweight. In this paper, we have investigated the role of domain size and the weight ratio of fullerene and non-fullerene acceptor on the performance of ternary blended PM6:Y6: PCBM organic solar cell. Using the effective medium approach and assuming the ternary blend of donor/acceptor1/acceptor2 nanocomposite as an effective integrated active layer, along with augmented Drift-diffusion formalism for the active layer of the organic solar cell, we have modeled the performance parameters of the device. The results show that the conversion efficiency of ternary solar cells depends on the distribution and size of both fullerene and non-fullerene acceptor domains. There are some optimal domain sizes where the optimum solar cell performance occurs. The obtained model results are in good agreement in comparison with experimental studies.
Pyrolysis of Polyolefins into Chemicals using Low-cost Natural Zeolites
Authors: Irawan Anton , Kurniawan Teguh , Nurkholifah N , Melina M. , Nandiyanto Asep Bayu Dani , Firdaus Mochamad Adha , Alwan Hafid , Bindar Yazid 
Published: June 2022

Abstract
Massive production of disposable plastic that is not supported with proper plastic waste management has created an environmental problem. One solution that could be done to address this situation is by transforming plastics into chemicals through pyrolysis route. An experimental study of pyrolysis from polyethylene (PE) and polypropylene (PP) has been done by catalytic method and utilization of low-cost natural zeolite in a semi-batch reactor. A low-cost natural zeolite made from acid-treated zeolite with 1 M HCl solution denoted as HZ. The prepared HZ catalyst was then carried out under pyrolysis reaction at 350, 400, 450 oC for 60 minutes. The chemical products composition from this reaction was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). According to the analysis result, a low-temperature reaction of pyrolysis could produce wax in all variant types of feed. Utilization of HZ catalyst could reduce formation wax while also increasing the yield of oil products after the reaction. Catalytic pyrolysis using HZ for PE and PP plastic feed yields oil products up to 67% and 70%, respectively. The composition of oil products mainly consisted of paraffin, olefin, and alcohol compounds. The temperature optimum for the catalytic reaction could produce the highest paraffin and olefin products at 400°C. Additionally, utilization of low-cost natural zeolite could improve pyrolysis reaction's performance from PP to produce yield olefin products from 39–62%.
Network Analysis Reveals Tumor Suppressor lncRNA GAS5 Acts as a Double-edged Sword in Gastric Cancer
Authors: Gupta Shantanu , Panda Pritam Kumar , Luo Wei , Hashimoto Ronaldo F. , Ahuja Rajeev 
Published: June 2022

Abstract
The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC). In contrast, E2F1, an important transcription factor, and tumor promoter, directly inhibits miR-34c expression in GC cell lines. Furthermore, in the corresponding GC cell lines, lncRNA GAS5 directly targets E2F1. However, lncRNA GAS5 and miR-34c remain to be studied in conjunction with GC. Here, we present a dynamic Boolean network to classify gene regulation between these two non-coding RNAs in GC. This is the first study to show that lncRNA GAS5 can positively regulate miR-34c in GC through a previously unknown molecular pathway coupling lncRNA/miRNA. We compared our network to several in-vivo/in-vitro experiments and obtained an excellent agreement. We revealed that lncRNA GAS5 regulates miR-34c by targeting E2F1. Additionally, we found that lncRNA GAS5, independently of p53, inhibits GC proliferation through the ATM/p38 MAPK signaling pathway. These findings open a new avenue for GC treatment.