bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Disturbance and SARS–CoV‐2 Vaccinations in Patients With Chronic Inflammatory Disease
Authors: Pawar Niti , Taylor Kimberly E. , Yang Monica , Deepak Parakkal , Kim Wooseob , Paley Michael A. , Matloubian Mehrdad , Carvidi Alex , Ciorba Matthew A. , Demissie Emanuel , El‐Qunni Alia , Huang Katherine , Kinnett Baylee , McMorrow Lily E. , Paez Diana , Poole Mackenzie , Rose Abigail , Schriefer Rebecca E. , Kim Alfred H. J. , Nakamura Mary , Katz Patricia , Gensler Lianne S. 
Published: December 2022

ObjectiveImmunocompromised patients with chronic inflammatory disease (CID) may have experienced additional psychosocial burden during the COVID‐19 pandemic due to their immunocompromised status. This study was undertaken to determine if vaccination would result in improved patient‐reported outcomes longitudinally among individuals with CID undergoing SARS–CoV‐2 vaccination regardless of baseline anxiety.MethodsData are from a cohort of individuals with CID from 2 sites who underwent SARS–CoV‐2 vaccination. Participants completed 3 study visits before and after 2 messenger RNA vaccine doses in the initial vaccination series when clinical data were collected. Patient‐reported outcomes were measured using the Patient‐Reported Outcomes Measurement Information System 29‐item Health Profile and expressed as T scores, with 2 groups stratified by high and low baseline anxiety. Mixed‐effects models were used to examine longitudinal changes, adjusting for age, sex, and study site.ResultsA total of 72% of the cohort was female with a mean ± SD age of 48.1 ± 15.5 years. Overall, sleep disturbance improved following both doses of SARS–CoV‐2 vaccinations, and anxiety decreased after the second dose. Physical function scores worsened but did not meet the minimally important difference threshold. When stratifying by baseline anxiety, improvement in anxiety, fatigue, and social participation were greater in the high anxiety group. Physical function worsened slightly in both groups, and sleep disturbance improved significantly in the high anxiety group.ConclusionSleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased, and anxiety, fatigue, and sleep disturbance decreased. Overall, results suggest that SARS–CoV‐2 vaccination may improve mental health and well‐being, particularly among those with greater anxiety.
Enhanced Thermoelectric Performance of p‐Type Mg3Sb2 for Reliable and Low‐Cost all‐Mg3Sb2‐Based Thermoelectric Low‐Grade Heat Recovery
Authors: Liang Zhongxin , Xu Congcong , Song Shaowei , Shi Xin , Ren Wuyang , Ren Zhifeng 
Published: December 2022

AbstractBi2Te3‐based devices have long dominated the commercial market for thermoelectric cooling applications, but their narrow operating temperature range and high cost have limited their possible applications for conversion of low‐grade heat into electric power. The recently developed n‐type Mg3Sb2‐based compounds exhibit excellent transport properties across a wide temperature range, have low material costs, and are nontoxic, so it would be possible to substitute the conventional Bi2Te3 module with a reliable and low‐cost all‐Mg3Sb2‐based thermoelectric device if a good p‐type Mg3Sb2 material can be obtained to match its n‐type counterpart. In this study, by comprehensively regulating the carrier concentration, carrier mobility, and lattice thermal conductivity, the thermoelectric performance of p‐type Mg3Sb2 is significantly improved through Na and Yb doping in Mg1.8Zn1.2Sb2. Moreover, p‐ and n‐type Mg3Sb2 are similar in terms of their coefficients of thermal expansion and their good performance stability, thus allowing the construction of a reliable all‐Mg3Sb2‐based unicouple. The decent conversion efficiency (≈5.5% at the hot‐side temperature of 573 K), good performance stability, and low cost of this unicouple effectively promote the practical application of Mg3Sb2‐based thermoelectric generators for low‐grade heat recovery.
Passivation of Bi2Te3 Topological Insulator by Transferred CVD‐Graphene: Toward Intermixing‐Free Interfaces
Authors: Galceran Regina , Bonell Frédéric , Camosi Lorenzo , Sauthier Guillaume , Gebeyehu Zewdu M. , Esplandiu Maria José , Arrighi Aloïs , Fernández Aguirre Iván , Figueroa Adriana I. , Sierra Juan F. , Valenzuela Sergio O. 
Published: December 2022

AbstractThe investigation, and ultimate application, of topological insulators, typically involve exposure to ambient conditions or their integration with metals, which lead to surface oxidation or material intermixing. X‐ray photoelectron spectroscopy (XPS) measurements that demonstrate passivated and intermixing‐free interfaces in the topological insulator Bi2Te3 by means of dry‐transferred CVD graphene are reported. After air exposure, no traces of Bi2Te3 oxidation are found. Furthermore, it is demonstrated that graphene acts as a very efficient metal and chalcogen diffusion barrier in Bi2Te3/graphene/permalloy (Py) heterostructures, which are relevant for spintronics. Such results are in stark contrast with the significant surface degradation observed in bare Bi2Te3 under ambient conditions and the deep BiTe bonding disruption that occurs in Bi2Te3/Py heterostructures. These findings provide a new approach to control and engineer topological insulator interfaces for spintronic applications and a new platform to investigate the combined use of graphene and topological insulator Dirac states.
Cobalt‐Catalyzed Cascade Reaction of Ynamides and 1,3‐Dicarbonyl Compounds for Selective Synthesis of Differently SizedN‐Heterocycles
Authors: Zhang Biao , Yang Xu‐Heng , Huang Jian , Tao Cheng‐an , Wang Jianfang 
Published: December 2022

AbstractA triphenylphosphine‐ligated cobalt‐catalyzed cyclization manifold with various 1,3‐dicarbonyl compounds and halogenatedN‐allyl ynamides was accomplished under alkaline reaction conditions, facilitating the synthesis of differently sizedN‐heterocycles. A large array of products was prepared to demonstrate the selective synthesis ofN‐heterocycles of different ring sizes (5‐, 6‐, and 7‐membered rings) via cobalt catalysis. The reaction has broad substrate scope and a wide range of functional groups.magnified image
Covalent Functionalization of Black Phosphorus Nanosheets with Photochromic Polymer for Transient Optoelectronic Memory Devices
Authors: Wu Dongchuang , Cui Xiaosheng , El‐Khouly Mohamed E. , Gu Minchao , Zhang Bin , Chen Yu 
Published: December 2022

AbstractHow to erase sensitive data stored on memory devices quickly in an emergency has become a critical issue that needs to be addressed. Using BP‐BIBB as a key template for atom transfer radical polymerization, which is prepared by the reaction of p‐hydroxyphenyl‐functionalized black phosphorous nanosheets (C6H4OH‐BP) with 2‐bromoisobutyryl bromide (BIBB), a highly soluble poly[4‐(4‐(3,3,4,4,5,5‐hexafluoro‐2‐(2‐methyl‐5‐phenylthiophen‐3‐yl)cyclopent‐1‐en‐1‐yl)‐5‐methylthiophen‐2‐yl)phenyl methacrylate] (PHPM)‐covalently grafted BP derivative, hereafter abbreviated as PHPM‐g‐BP, is synthesized in situ. PHPM is a typical photochromic polymer that emits blue light under UV irradiation, while showing pale yellow under visible light illumination. By using PHPM‐g‐BP as an active layer, an as‐fabricated transient optoelectronic memory device exhibits a nonvolatile rewritable memory effect under UV irradiation, with an ON/OFF current ratio of 3.6 × 103, a turn‐on voltage of 1.60 V, and a turn‐off voltage of −1.41 V. Upon visible light illumination for 10 s, all the information stored in the device is erased quickly. The observed device current drops down from 10−3 to 10−8 A rapidly.
Electrospun Stacked Dual‐Channel Transistors with High Electron Mobility Using a Planar Heterojunction Architecture
Authors: He Bo , He Gang , Jiang Shanshan , Liu Jiangwei , Fortunato Elvira , Martins Rodrigo 
Published: December 2022

AbstractThin‐film transistors based on metal oxide semiconductors have become a mainstream technology for application in driving low‐cost backplanes of active matrix liquid crystal displays. Although significant progress has been made in traditional marketable devices based on physical vapor deposition derived metal oxides, it has still been hindered by low yield and poor compatibility. Fortunately, developing solution‐based 1D nanofiber networks to act as the fundamental building blocks for transistor has proven to be a simpler, higher‐throughput approach. However, oxide transistors based on such princesses suffer from degraded carrier mobility and operational instability, preventing the ability of such devices from replacing present polycrystalline Si technologies. Herein, it is shown that double channel heterojunction transistors with high electron mobility (>40 cm2 V−1 s−1) and operational stability can be achieved from electrospun double channels composed of In2O3 and ZnO layers. Adjusting the stacking order and the stacking density of In2O3 and ZnO layers can effectively optimize the interface electron trap, leading to the formation of 2D electron gas and the reduction of stress‐induced instability. These findings further elucidate the significant advance of electrospinning‐derived double channel heterojunction transistors toward practical applications for future low‐cost and high‐performance electronics.
Emerging Antibodies in Cancer Therapy
Authors: Sun Yaping , Xu Jian 
Published: December 2022

Since the first monoclonal antibody, Orthoclone OKT3, was approved in 1986 for the treatment of acute allograft rejection in renal transplant recipients, the number of antibody‐based therapies has increased remarkably, with more than 130 monoclonal antibodies being currently available. In particular, due to their robust binding affinity and high specificity, various monoclonal antibodies have achieved success as complementary antitumor drugs. Moreover, therapeutic potency can be improved by engineering Y‐shaped binding sites of the antibodies to simultaneously recognize two distinct antigens; such molecules are called bispecific antibodies and function as a bridge, with one site binding to a tumor‐specific antigen and the other to immune cells to activate host immune responses. In addition, the development of trispecific antibodies has led to further enhancement of therapeutic specificity and effects. Indeed, a variety of structurally engineered antibodies have proven effective in tumor therapy. This article provides insights into the clinical translation of emerging antibody constructs, firstly describing conventional T cell‐redirecting bispecific antibodies and subsequently discussing the application of bispecific and trispecific antibody constructs based on innate immune cell recruitment. Finally, bispecific antibodies against mutant p53 and KRAS that have been actively studied in cancer treatment are introduced.
Dicyanoimidazole resin with bisphenol A moiety: Synthesis, processing, properties, and composites
Authors: Zhu Zhengzhu , He Xian , Lv Jiangbo , Xiao Hang , Pu Yu , Hong Jinlang , Zeng Ke , Hu Jianghuai , Yang Gang 
Published: December 2022

AbstractDeveloping high‐performance polymer (HPP) with improved properties by green processing method is one of the core parts of HPP research. In this paper, a new monomer (4,4′‐((propane‐2,2‐diylbis(4,1‐phenylene))bis(oxy))dibenzaldehyde (PBhDCI)) of high‐performance aromatic nitrile‐based (AN) resins with good solubility in ethanol was designed. The rheological analysis showed that PBhDCI is suitable for the processing by laminating process. The cured resins and the corresponding carbon fiber reinforced plastics (CFRP) showed outstanding thermal and mechanical properties. The thermal decomposition temperature (T5%) of the cured PBhDCI under nitrogen up to 510°C, the glass transition temperature (Tg) of both resin matrix and CFRP exceeds 500°C, and the flexural strength and modulus of CFRP were 507 ± 5 MPa and 59 ± 2 GPa. This work will offer some guidance for the preparation of high‐performance resins and corresponding CFRP with a green processing and high thermal and mechanical properties.
Robust fabrication of poly(lactic acid) membrane with good hemocompatibility over heparin‐mimetic graphene‐based nanosheets
Authors: Huang Lilan , Ma Lankun , Chen Haimei , Qiao Lei , Zhang Leitao , Pan Jian , Li Jinwei , Zhang Yuzhong 
Published: December 2022

AbstractDeveloping dislysis membranes with outstanding hemocompatibility is the key of hemodialysis used for curing the kidney malfunction. Herein, polylactic acid (PLA) membrane with high water flux (640.2 L m−2 h−1) and bovine serum albumin (BSA) rejection (>97%) is prepared and subsequently modified by heparin‐mimetic sulfonated graphene oxide (SGO) via modified mussel‐inspired method. The (NH4)2Fe(SO4)2 serves as Fenton catalyst significantly accelerates the oxidized polymerization of dopamine (DA) in DA‐g‐SGO to form polydopamine‐g‐SGO (PDA‐g‐SGO). The uniform immobilization of SGO significantly improves the hydrophilicity and electronegativity of the PLA membranes, inhibiting platelets adhesion. Moreover, the sulfonic group of SGO plays the role of anticoagulant as heparin. The obtained PLA/PDA‐g‐SGO membrane exhibits excellent hemocompatibility with longer recalcification time (230 s) and lower hemolysis ratio (1.6%) than those of original PLA membrane (120 s, 10.7%). This study demonstrates a potential way to improve the hemocompatibility of polymeric membranes.
Solvent‐free synthesis of phosphate‐containing imidazole fluid for flame retardant one‐component epoxy resin with long pot life, low curing temperature and fast curing rate
Authors: Wang Wei , Chen Gang , Wu Shulong , Liu Yuan , Wang Qi 
Published: December 2022

AbstractThe design of flame retardant one‐component epoxy resin (EP) with long pot life, low curing temperature and fast curing rate has been challenging in the industry. Herein, we synthesized a phosphate‐containing imidazole fluid (TA) as the thermal latent curing agent of EP. Based on simple structural design, TA endows EP with excellent curing properties, storage properties, and flame retardant properties. According to DSC results, EP/TA systems exhibit low curing temperature and fast curing rate during operation. The rotary rheometer test confirms that the viscosity curve of EP/TA system maintains long‐term stability at 40°C. The X‐ray photoelectron spectroscopy (XPS) data reveals that TA releases imidazole intermediates and phosphorous compounds during curing. The former provides conditions for fast curing of EP, while the latter gives EP intrinsic flame retardant properties. With the addition of 20 wt.% TA, EP/TA‐4 achieves UL‐94 V‐0 rating and 28.5% of LOI value. The study of flame retardant mechanism shows that the flame retardancy of TA mainly comes from the protective effect of phosphorus‐rich char layer, the dilution effect of non‐combustible gas and quenching effect of phosphorous compound. Besides, due to no solvent involved, the synthesis strategy of TA is environmentally friendly, showing a great potential of industrial application.
Picolinamide Ligands: Nickel‐Catalyzed Reductive Cross‐Coupling of Aryl Bromides with Bromocyclopropane and Beyond
Authors: Han Dongyang , Sun Jie , Jin Jian 
Published: December 2022

AbstractThe arylcyclopropane motif as the combination of aryl and cyclopropyl ring systems can be found in an increasing amount of approved and investigational drugs. Herein, we have developed a mild, efficient nickel‐catalyzed reductive cross‐coupling protocol, featuring a simple Ni(II) precatalyst and a novel picolinamide NN2 pincer ligand. A variety of (hetero)aryl bromides could successfully couple with cyclopropyl bromide to furnish the valued arylcyclopropanes in good to excellent yields. This method is applicable to other alkyl bromides as well. Notably, the reaction is tolerant of a broad range of functionalities including free amines. Furthermore, the synthesis of several significant intermediates of bioactive molecules was achieved in grams, proving the practicability of this method.
Estimation of First Order Plus Dead Time and Second Order Plus Dead Time models from noisy step response data
Authors: Maxim Anca , De Keyser Robin 
Published: December 2022

SummaryThis paper proposes the estimation of first‐order‐plus‐dead‐time (FOPDT) and second‐order‐plus‐dead‐time (SOPDT) models from noisy step response data. The model parameters are estimated by computation of areas, which makes it robust in the presence of stochastic disturbances in the step response data. The efficiency of the methodology is extensively tested in various numerical examples as well as in real‐life experimental tests. The results—comparing our proposed estimation method with some other methods—suggest that the novel algorithm can be used with noisy step response data and adequately approximates high‐order systems. Moreover, it does not require any system identification expertise, making it readily accessible for the nonexperienced user in industrial practice. The method is successfully validated for overdamped, reasonably underdamped, as well as highly oscillatory processes, hence offering a comprehensive estimation method.
Increasing production of spinosad inSaccharopolyspora spinosaby metabolic engineering
Authors: Bridget Adzemye Fovennso , Nguyen Chung Thanh , Magar Rubin Thapa , Sohng Jae Kyung 
Published: December 2022

AbstractSpinosad, a combination of spinosyn A and D produced bySaccharopolyspora spinosa, is a highly efficient pesticide. There has been a considerable interest in the improvement of spinosad production because of a low yield achieved by wild‐typeS. spinosa. In this study, we designed and constructed a pIBR‐SPN vector. pIBR‐SPN is an integrative vector that can be used to introduce foreign genes into the chromosome ofS. spinosa. Different combinations of genes encoding forasamine and rhamnose were synthesized and used for the construction of different recombinant plasmids. The following recombinant strains were developed:S. spinosapIBR‐SPN (only the vector),S. spinosapIBR‐SPN F (forosamine genes),S. spinosapIBR‐SPN R (rhamnose genes),S. spinosapIBR‐SPN FR (forosamine and rhamnose genes),S. spinosapIBR‐SPN FRS (forosamine, rhamnose, and SAM [S‐adenosyl‐L‐methionine synthetase] genes), andS. spinosaMUV pIBR‐SPN FR. Among these recombinant strains,S. spinosapIBR‐SPN FR produced 1394 ± 163 mg/L spinosad, which was 13‐fold higher than the wild‐type.S. spinosaMUV pIBR‐SPN FR produced 1897 (±129) mg/L spinosad, which was seven‐fold higher thanS. spinosaMUV and 17‐fold higher than the wild‐type strain.
Systematic review of reported association studies of monogenic genes and bladder cancer risk and confirmation analysis in a large population cohort
Authors: Mian Abrar , Wei Jun , Shi Zhuqing , Rifkin Andrew S. , Zheng S. Lilly , Glaser Alexander P. , Kearns James T. , Helfand Brian T. , Xu Jianfeng 
Published: December 2022

AbstractObjectivesTo evaluate which of previously reported monogenic genes are associated with increased bladder cancer risk, we reviewed published papers on associations of genes and bladder cancer risk and performed a confirmation study of these genes in a large population‐based cohort.Subjects and methodsA systematic review of published papers prior to June 2022 was performed first to identify all genes where germline mutations were associated with bladder cancer risk. The associations of these candidate genes with bladder cancer risk were then tested among 1695 bladder cancer cases and 186 271 controls in the UK Biobank (UKB). The robust SKAT‐O, a gene‐based analysis that properly controls for type I error rates due to unbalanced case–control ratio, was used for association tests adjusting for age at recruitment, gender, smoking status, and genetic background.ResultsThe systematic review identified nine genes that were significantly associated with bladder cancer risk in at least one study (p < 0.05), including MUTYH, MSH2, MSH6, MLH1, ATM, BRCA2, ERCC5, TGFB1 and CHEK2. When pathogenic/likely pathogenic mutations were aggregated within each gene, the association was confirmed for three genes in the UKB at p < 0.0056 (Bonferroni correction for nine tests), including CHEK2, ATM and BRCA2, all also known to be associated with hereditary breast cancer. Suggestive evidence of association was found for two other genes, including MLH1 (p = 0.006) and MSH2 (p = 0.007), both known to be associated with Lynch syndrome. Among these five genes, the bladder cancer risks range from 1.60 (ATM) to 4.88 (MLH1), and mutation carrier rates in cases range from 0.06% (MSH2) to 2.01% (CHEK2).ConclusionThis study provides statistical evidence for association of previously reported genes and bladder cancer risk and has clinical utility for risk assessment and genetic counselling.
Looking up or down on the social ladder: How socioeconomic comparisons shape judgments about monetary and time donations
Authors: Demczuk Rafael , Mantovani Danielle , Fernandes Daniel 
Published: December 2022

AbstractThe increasing inequality rate within countries worldwide makes social comparisons more evident. In seven experiments, we demonstrate that people comparing themselves to others in a superior socioeconomic position (upward comparison) judge that wealthier others should donate more time and money to charity. However, social comparison to others in an inferior position (downward comparison) does not always increase monetary donations. This discrepancy in prescriptions for monetary donations between those who make upward and downward social comparisons is driven by judgments about relative spare money; while people making upward comparisons believe that others have more spare money, people making downward comparisons only think they have more spare money, and should donate more, when reminded of their hierarchical position at the time of judgment. Low meritocracy beliefs exacerbate the difference between the prescriptions of how much oneself and others should donate given their socioeconomic position. This differential pattern among individuals making upward and downward social comparisons helps to propagate economic inequality. People making upward comparisons prescribe to wealthier others the responsibility to donate to charity, who in turn may not think they should donate more money. These findings have implications for charitable and non‐profit organizations and contribute to research on social comparison, inequality, and judgments about monetary and time donations.
“K‐synthesis”: Recent advancements in natural product synthesis enabled by unique methods and strategies development in Korea
Authors: Han Sunkyu 
Published: December 2022

AbstractNatural product synthesis has lain at the heart of organic chemistry. Complex structures of natural products have inspired chemists to develop new methods and strategies. The utility and robustness of newly developed methodologies have been tested by their application into total synthesis. With the necessity to establish a solid health‐related and biomedical Korean industrial ecosystem, a historically belittled sector when compared to well‐invested manufacturing and electronics industries in Korea, there has been enormous recent progress in the Korean organic chemical research. Accordingly, impressive syntheses of complex secondary metabolites that feature unique tactics and ingenious strategies have been reported by synthetic organic chemists in Korea. Herein, recent advancements (mostly after 2010) in natural product synthesis from Korea are depicted. Representative accomplishments from researchers in Korea are presented with an emphasis on unique methods and strategies that are utilized into their synthetic approaches.