bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening CEACAM8 and LCN2 as immune-related diagnostic biomarkers after burn to prevent serious complications
Authors: Wang Jia-Xin , Zou Lin-Xuan , Zhao Tian-Qi , Xu Meng-Ying , Yi Xin , Wang Xing-Kai , Qu Xue-Ling , Zong Jun-Wei , Wang Shou-Yu 
Published: August 2022

Abstract
Background: Burns are an underrated injury that can affect anyone, anytime and anywhere. Therefore, screening immune-related diagnostic markers of burn can be used to prevent serious complications and death.Methods: GEO database obtains GSE19743 and GSE37069, and uses the GPL570 platform. Cibersort algorithm was used to calculate the figure of immune cells in healthy control group and burn group. Immune cells were identified by Least Absolute Shrinkage and Selection Operator (LASSO) regression. “RobustRankAggreg” method was used to screen differentially expressed genes. DEGs' functional correlation was analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Possible biomarkers were identiﬁed by Cytoscape's cytoHubba, and the diagnostic result was predicted Receiver Operator Characteristic Curve (ROC) analysis. Spearman's rank correlation analysis in R package was used to learn the correlation between the identiﬁed biomarkers and inﬁltrating immune cells. Results: After joint analysis of the two sets of data, 60 DEGs were obtained, of which 42 increased and 18 decreased. Generally speaking, the function of DEG is related to immune cells. In CytoHubba, 6 hub genes were obtained through the intersection of 10 algorithms. GZMB, OLFM4, ELANE, MMP9, LCN2 and CEACAM8 showed good specificity and sensitivity, respectively. The correlation between 6 effective biomarkers and 12 meaningfully different immune cells in burn group was analyzed. The outcomes demonstrated that LCN2 was correlated with M0 macrophages positively (R=0. 594, P < 0.001).Conclusion: CEACAM8 and LCN2 have great potential as new diagnostic biomarkers of immune dysfunction after burn.
Dynamic Computation Offloading with Deep Reinforcement Learning in Edge Networks
Authors: Bai Yang , Li Xiaocui , Wu Xinfan , Zhou Zhangbing 
Published: August 2022

Abstract

With the booming proliferation of user requests in the Internet of Things (IoT) network, Edge Computing (EC) is emerging as a promising paradigm to provide flexible and reliable services. Considering the resource constraints of IoT devices, for some delay-aware user requests, a heavy workload IoT device may not respond on time. EC spurs a popular wave of offloading user requests to edge servers at the edge of the network. The orchestration for user-requested offloading schemes is a remarkable challenge for the execution time and energy consumption for IoT devices in edge networks. To address this challenge, we propose a dynamic computation offloading strategy consisting of the following two parts: (i) we propose the concept of intermediate nodes, which can minimize the time and energy cost to process the current task by dynamically combining task offloading and service migration strategies; and (ii) based in the current network’s workload state, we model such intermediate node selection problem as multiple dimensional Markov Decision Process (MDP) spaces and implement deep reinforcement learning algorithms to reduce the large MDP space and achieve fast decision-making. Experimental results show that this strategy performs better than existing baseline approaches on the reduction of delay and energy consumption.
RIPF-Unet for regional landslides detection: a novel deep learning model boosted by reversed image pyramid features
Authors: FU Bangjie , LI Yange , Han Zheng , FANG Zhenxiong , CHEN Ningsheng , HU Guisheng , WANG Weidong 
Published: August 2022

Abstract
Rapid detection of landslides using remote sensing images benefits hazard assessment and mitigation. Many deep learning-based models have been proposed for this purpose, however, for small-scale landslide detection, excessive convolution and pooling process may cause potential texture information loss, which can lead to misjudgement of landslide target. In this paper, we present a novel UNet model for automatic detection of landslides, wherein the reversed image pyramid features (RIPFs) are adapted to compensate for the information loss caused by a succession of convolution and pooling. The proposed RIPF-Unet model is trained and validated using the open-source landslides dataset of the Bijie area, Guizhou Province, China, wherein the precision of the proposed model is observed to increase by 3.5% and 4.0%, compared to the conventional UNet and UNet + + model, respectively. The proposed RIPF-Unet model is further applied to the case of the Longtoushan region after the 2014 Ms.6.5 Ludian earthquake. Results show that the proposed model achieves a 96.63% accuracy for detecting landslides using remote sensing images. The RIPF-Unet model is also advanced in its compact parameter size, notably, it is 31% lighter compared to the UNet + + model.
The presence of partial compaction patterns is associated with lower rates of blastocyst formation, sub- optimal morphokinetic parameters and poorer morphologic grade
Authors: Hur Christine , Nanavaty Vaani , Yao Meng , Desai Nina 
Published: August 2022

Abstract
Background: Compaction is an important marker of embryonic genome activation and marks a critical step in the development to blastocyst. The objective of our study was to determine whether visualization of the embryonic compaction process through time-lapse imaging (TL) can assist in predicting the kinetics of embryo development as well as the likelihood for blastocyst formation, grade, or ploidy.Methods: This study is a retrospective review of prospectively collected data from a single academic institution. Couples included were those who underwent preimplantation genetic testing for aneuploidy (PGT-A) following in vitro fertilization between January and December 2020. Embryos were cultured in the Embrysocope. Embryo morphokinetic data was prospectively collected and analyzed. TL videos were later reviewed in detail for compaction pattern. Embryo compaction patterns (CP) were categorized as follows: 1) full compaction (CP-F), 2) partial compaction with cell extrusion (P-ext), 3) partial compaction with cell exclusion (P-exc) and 4) partial compaction with both cell extrusion and exclusion (P-both). Assessment of embryo decompaction and re-compaction was evaluated. The association between CP, morphokinetic parameters, blastocyst formation, grade and ploidy were then analyzed.Results: A total of 349 embryos were studied. Amongst embryos which progressed to morula (n=281), the distribution of compaction patterns were: CP-F 45.6%, P-ext 12.5%, P-exc 29.5% and P-both 12.5%. Embryos exhibiting a CP-F were more likely to proceed to blastocyst compared with those that demonstrated partial compaction patterns (p = 0.006). When compared to CP-F, partial compaction patterns were significantly associated with poorer ICM and TE grades (P < 0.001). Of the 281 morula, 59.8% (n = 168) demonstrated at least one episode of decompaction and re-compaction. Of the 249 blastocysts formed, 200 were cryopreserved for future use after undergoing PGT-A evaluation. Of those, 42.5% were diagnosed as euploid, 39.0% as aneuploid, 9.0% as mosaic and 9.5% had no result. When compared to CP-F, partial CPs exhibited a significantly greater percentage of mosaic embryos (3.6% v. 15.6%, p=0.032). Additionally, we found that a greater percentage of embryos demonstrating CP-F exhibited morphokinetics that fell into optimal ranges for embryo development when compared to those with partial compaction patterns. Conclusion: Time-lapse visualization of compaction patterns identified exclusions and/or extrusions as negative indicators of blastocyst formation and blastocyst grade. When compared to full compaction patterns, partial compaction patterns were associated with delayed embryonic development as well as lower rates of optimal kinetic development.
Low Voltage a-IGZO Thin Film Transistor Using Tantalum Oxide by Thermal Oxidation
Authors: Yu Eun Seong , Kang Seo Jin , Lee Hyuck Su , Lee Jong Mo , Bae Byung Seong 
Published: August 2022

Abstract
Low voltage oxide thin-film transistors (TFTs) operating below 1.0 V were developed using a high dielectric constant tantalum oxide produced by thermal oxidation. Thermal oxidation was carried out at 400, 500, and 600 °C under an oxygen atmosphere. The tantalum oxide was evaluated by X-ray photoelectron spectroscopy (XPS). XPS confirmed the binding energy of Ta4f, indicating the binding state of tantalum oxide. The bottom gate oxide TFT with the gate insulator of tantalum oxide grown at 500 °C exhibited mobility of 12.61 cm2/V and a threshold voltage of 0.46 V. The transfer characteristics at the drain voltages below 1.0 V show its applicability to low voltage operation below 1 V. The bootstrapped inverter with developed oxide TFTs operated well at the operation voltages of both the 1.0 and 2.0 V.
Team effectiveness: epidemiologists' perception of collective performance during emergency response
Authors: Parry Amy Elizabeth , Richardson Alice , Kirk Martyn , Colquhoun Samantha , Durrheim David N , Housen Tambri 
Published: August 2022

Abstract
Background: To describe epidemiologists’ experience of team dynamics and leadership during emergency response, and explore the utility of the Team Emergency Assessment Measure (TEAM) tool during future public health emergency responses. The TEAM tool included categories for leadership, teamwork, and task management.Methods: We conducted a cross-sectional survey between October 2019 and February 2020 with the global applied field epidemiology workforce. To validate the TEAM tool for our context, we used exploratory and confirmatory factor analysis. Results: We analysed 166 completed surveys. Respondents included national and international emergency responders with representation of all WHO regions. We were unable to validate the TEAM tool for use with epidemiology teams involved in emergency response, however descriptive analysis provided insight into epidemiology emergency response team performance. We found female responders were less satisfied with response leadership than male counterparts, and national responders were more satisfied across all survey categories compared to international respondersConclusion: Functional teams are a core attribute of effective public health emergency response. Our findings have shown a need for a greater focus on team performance. We recommend development of a fit-for-purpose performance management tool for teams responding to public health emergencies. The importance of building and supporting the development of the national workforce is another important finding of this study.
Disposable laryngoscope intubation to reduce equipment failure in an emergency out of OR setting - A Quality Control Case Study
Authors: Simmons Colby G. , Eckle Tobias , Rogers Dustin , Williams Jason D. , Brainard Jason C. 
Published: August 2022

Abstract
Background
Reusable laryngoscopes have been reported to be superior to disposable laryngoscopes with plastic blades during emergent intubations. Surprisingly, at our institution a quality reporting system revealed a high number of equipment failures with reusable laryngoscopes in an emergency out-of-OR (operating room) setting. As recent studies indicated an improved quality of disposable laryngoscopes, we hypothesized that a thoroughly evaluated disposable laryngoscope would result in less equipment failure in an emergency out-of-OR setting.
Methods
To perform a more standardized and time efficient analysis, four distinct disposable laryngoscope blade/handle configurations were trialed during standard intubations (n = 4x30) in the OR by experienced anesthesia providers who completed a 6-question, Likert-scale/open-ended survey for product evaluation. The ‘best’ disposable blade was implemented in an emergency out-of-OR setting and equipment failure rates were monitored over a 3-year period.
Results
Different disposable laryngoscopes were equal regarding sturdiness, illumination and airway visualization. The laryngoscope with the highest overall score was significantly higher scored than the laryngoscope with the lowest overall score. All disposable laryngoscopes were more cost effective than the reusable ones, and the top scored laryngoscope demonstrated the highest 5-year cost-saving ($210K). Implementation of the top scoring disposable laryngoscope into an emergency out-of-OR setting reduced the equipment failure incidence from high 20s to 0.
Conclusion
Disposable laryngoscopes are cost effective and superior to reusable laryngoscopes in an emergency out-of-OR setting. We demonstrate that the implementation of a disposable laryngoscope in the emergency out-of-OR setting resulted in a near elimination of equipment related quality submissions which ultimately enhances patient safety.
Effect of internal heat source on a nonlocal thermoelastic rotating medium in the context of a dual-phase-lag model with fractional derivative
Authors: Said Samia M. , Abd-Elaziz Elsayed M. , Othman Mohamed I. A. 
Published: August 2022

Abstract
A new model of a rotating nonlocal thermoelastic medium is formulated based on the dual-phase-lag model with fractional derivative heat transfer. Using suitable non-dimensional variables, the problem is solved using Fourier series and Laplace transforms to obtain the exact expressions of physical fields. The distributions of the nondimensional temperature, displacements, and stresses are obtained and illustrated graphically. The effects of the rotation, the nonlocal parameter, the internal heat source, and the fractional- order parameter, on the considered variables are concerned and discussed in detail, and the results show that they significantly influence the variations of the considered variables.
Time course of adverse reactions after BNT162b2 vaccination in healthy and allergic disease individuals aged 5–11 years: an observational and historical cohort study
Authors: Yoshida Makoto , Kobashi Yurie , Shimazu Yuzo , Saito Hiroaki , Yamamoto Chika , Kawamura Takeshi , Wakui Masatoshi , Takahashi Kenzo , Ito Naomi , Nishikawa Yoshitaka , Zhao Tianchen , Tsubokura Masaharu 
Published: August 2022

Abstract
Purpose
We aimed to assess whether BNT162b2 vaccination in children meets high safety standards by surveying adverse reactions in healthy and allergic disease individuals aged 5–11 years in Japan throughout seven days following their first and second BNT162b2 vaccination.
Methods
This was an observational and historical cohort study. The eligibility criteria of study participants included those aged 5–11 years, who received two doses of BNT162b2, with consent by the children and their guardians. We collected data on sex, age, height, weight, blood type, history of BCG vaccination, allergic disease, medication, history of COVID-19 infection and adverse reactions seven days following the first and second BNT162b2 vaccination using a questionnaire. We used previous reports to compare our result with individuals aged 12–15years.
Results
A total of 421 participants were eligible for this study. Among the 216 patients with allergic disease, 48 (22.2%) had experienced worsening of their chronic diseases, and the frequency of fatigue and dizziness after the second dose was higher than that of healthy individuals. The experience of systemic adverse reactions was associated with asthma. The frequency of headache, diarrhea, fatigue, muscle/joint pain, and fever after the second BNT162b2 vaccination was lower in the individuals aged 5–11 years than in those aged 12–15 years. Fever was the only systemic adverse reaction that lasted longer than five days (1.0% of participants).
Conclusions
Individuals with allergic diseases, who are potentially susceptible to COVID-19, may experience worsening of their chronic diseases and more frequent adverse reactions after BNT162b2 vaccination than healthy individuals. To ensure that children with allergic diseases receive the vaccine safely, further information needs to be collected.
Clinical validation of a fully automated framework for ventricular segmentation and wall motion classification from cine CMR
Authors: Costa Eva , Barros Carla , Pinto Adriano , Martins Nelson , Tondi Lara , Pica Silvia , Pereira Vitor Hugo , Lombardi Massimo 
Published: August 2022

Abstract
Background
We present the clinical validation of an AI-based framework for automatic ventricular segmentation and quantification, and automatic wall motion classification from cine CMR.
Methods
The framework was evaluated using two datasets, the SCMR Consensus dataset and a cohort private dataset composed by 146 patients. The automatic segmentation of left ventricle (LV) of SCMR Consensus dataset was evaluated through Dice Similarity Coefficient (DSC). The ventricular function quantification was assessed by processing both datasets, measuring LV and right ventricle (RV) end-diastolic and end-systolic volumes, ejection fraction (EF), and left ventricle mass (LVM). The validation was based on agreement indices, such as the intra-class correlation coefficients (ICC). Automatic wall motion classification was performed using the cohort dataset, and assessed using confusion matrix metrics.
Results
The comparison between the proposed framework and experts' manual performances on ventricular segmentation and function quantification processes showed high levels of contouring overlap (DSC=0.72), and agreement (ICC > 0.96 and ICC > 0.81 for volumes and EFs of LV and RV, respectively, and ICC > 0.78 for LVM). The automatic wall motion analysis obtained a classification accuracy of 0.77, with a sensitivity value of 1.00, meaning no false negative..
Conclusions
The validation results confirmed the proposed framework robustness and generalization capabilities. Moreover, our proposal demonstrated its potential for automatic wall motion classification in clinical practice.
The effect of calcineurin signaling inhibition on the treatment of endometriosis in rats
Authors: Bulbul Cagla Bahar , Turan Gulay , Usta Ceyda Sancakli , Bulmus Ozgur , Usta Akin 
Published: August 2022

Abstract
Objective
The molecular and cellular mechanism underlying endometriosis is still under investigation. CypA is one of the inflammatory marker which secreted various type of cell in the inflammatory condition. During the inflammation, CypA exacerbate inflammatory response by the activation of calcineurin signaling that increases the cytokine secretion and tissue degradation in inflammatory region. The aim of this study was to investigate the effect of calcineurin signaling inhibition on the treatment endometriosis in rats.
Materials & Methods
In the present study, 32 albino-wistar rat were used. All rats were divided into three groups as Cyclosporin A (n = 10), tacrolimus (n = 10) and control group (n = 12). Cyclosporin A group was administered intraperitoneal and tacrolimus group was administered intravenous, total 2 doses at intervals of 2 weeks respectively. All studies lasted for 8 weeks. Processed endometrial tissues will cut at the middle of the tissue samples and embedded into paraffin. Histological sections (5 µm) were stained with Ki-67, Bcl-2, Caspase-3 and VEGF.
Results
The size of endometriotic focus were 204.7 ± 153.4 mm3, 71.9 ± 85.4 mm3 ve 30.6 ± 36.7 mm3 in control, in CsA and in tacrolimus groups. Compared the control group the size of endometriotic focus was lower in CsA and tacrolimus group (p = 0.002). Microscopically, Ki-67 (p = 0.010) and VEGF (p = 0.007) immunoreactivity were lower in CsA and tacrolimus group than controls.
Conclusion
The inhibition of calcineurin signaling with CsA and tacrolimus treatment causes regression of endometriotic focus via decreases of endometriotic cell proliferation and angiogenesis in ectopic endometriotic tissue.
Dietary outcomes of moderately wasted children treated in a food voucher program in Cameroon’s Far North: A three-month longitudinal study
Authors: Foudjo Brice Ulrich Saha , Teta Ismael , Nielsen Jennifer Notkin , Kang Yunhee , Nguefack-Tsague Georges , Nounkeu Carole Debora , Touré Djeinam , Doledec David , Oben Julius 
Published: August 2022

Abstract
Background
Many interventions in Cameroon focus on addressing severe wasting rather than targeting moderate wasting, although the latter is more prevalent. The objective of the study was to evaluate a program designed to treat moderate wasting using a food voucher program (FVP) tested in the Far North, examining the factors associated with dietary outcomes.
Methods
A three-month longitudinal study was carried out to evaluate the impact of providing caregivers of children with moderate wasting (middle-upper arm circumference [MUAC] measures < 125 mm) a bi-weekly voucher to purchase a predefined package of foods together with essential hygiene and nutrition education on child minimum dietary diversity (MDD) and dietary diversity scores (DDS). Life table analysis was used to assess the cumulative probability of achieving the MDD among children aged 6–23 months, and multivariate regression was used to assess changes in DDS among children 24–59 months. Factors associated with dietary outcomes were identified using random and fixed effect (mixed) linear and logistic models.
Results
A total of 474 children were enrolled in the study. The FVP components increased the proportion of children achieving intended dietary outcomes. The cumulative probability of meeting the MDD by children 6–23 months of age increased from 19.9% at enrollment to 100% after 12 weeks. Average DDS scores increased from 3.2 at baseline to 5.1 (95% CI 4.6–5.7) across enrollment. Caregivers’ perception of the safety of food items redeemed was positively associated with MDD increase (adjusted RR = 0.50, p = 0.012). Family member consumption of the enriched porridge was more likely to decrease DDS among children aged 24–53 months (adjusted coef. = 0.33, p = 0.047).
Conclusion
The FVP was effective in improving dietary diversity of MAM children aged between 6–59 months in Cameroon’s Far North.
Molecular Cloning, Characterization and Expression Analysis of Auxin Response Factor GhARF2 Gene in Upland Cotton (Gossypium hirsutum L.)
Authors: Chao Maoni , Dong Jie , Hu Genhai , Li Yanyan , Huang Ling , Zhang Jinbao , Tang Jihua , Wang Qinglian 
Published: August 2022

Abstract

Auxin response factors (ARFs) are a class of transcription factors that regulate the expression of auxin-responsive genes and play important functions in plant growth and development. To understand the biological functions of the auxin response factorGhARF2gene in upland cotton, the coding sequence (CDS) ofGhARF2gene was cloned, and its protein sequence, evolutionary relationship, subcellular localization and expression pattern were analysed. The results showed that the full-length CDS ofGhARF2gene was 2,583 bp, encoded 860 amino acids, and had a molecular weight and an isoelectric point of 95.46 KDa and 6.02, respectively. The GhARF2 protein had multiple phosphorylation sites, no transmembrane domain, and secondary structures dominated by random coils and α-helices. The GhARF2 protein has 3 conserved typical domains ofARFgene family members, including the B3 DNA binding domain, the Auxin_resp domain, and the Aux/IAA domain. Phylogenetic analysis revealed that ARF2 proteins in different species were clustered in the Group A subgroup, in which GhARF2 was closely related to TcGhARF2 ofTheobroma cacaoL. (Malvaceae). The subcellular localization results showed that the GhARF2 protein was localized in the nucleus. Analysis of tissue expression pattern showed that theGhARF2gene was expressed in all tissues tested, with the highest expression level in sepal, followed by leaf, and the lowest expression level in fiber. Further stress expression analysis showed that theGhARF2gene was induced by drought, high-temperature, low-temperature and salt stress, and had different expression patterns under different stress conditions. These results established a foundation for understanding the functions ofGhARF2and breeding varieties with high-stress resistance in cotton.