bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conselho de Administração na Flexibilidade Estratégica de Empresas Familiares
Authors: Weissmantel Cristiane Wornath , Meurer Tatiane , Hein Nelson , Beck Franciele 
Published: February 2025

A flexibilidade estratégica é uma importante qualidade para as empresas se manterem competitivas e atuantes, por isso entender o que está por trás dessa característica das empresas é essencial, principalmente quando se trata de empresas familiares, que prezam tanto pela continuidade dos negócios para as próximas gerações. Assim, esse estudo tem como objetivo analisar o controle da família e a composição do conselho de administração na Flexibilidade Estratégica de empresas familiares. Para tanto, esta pesquisa caracteriza-se como descritiva, survey, e com abordagem quantitativa. A amostra da pesquisa correspondeu a 109 empresas familiares brasileiras do gênero alimentício, o qual foi enviado um questionário eletrônico. Para a análise dos dados foi realizado Cluster K-means. Confirmou-se por meio do modelo empírico testado, que as empresas controladas por apenas uma família e com menor participação da família no conselho tem maior flexibilidade estratégica (Cluster 3). Confirmou-se que mais de uma família no controle da empresa e ausência de conselho de administração resultou em menor flexibilidade estratégica (Cluster 2). O Cluster 1 é composto por empresas controladas por uma ou mais famílias e majoritariamente por empresas que têm mais membros familiares no conselho de administração. Por fim, o Cluster 3 apresentou diferença de média da flexibilidade estratégica quando comparado com o Cluster 1 e o Cluster 2. Este estudo contribuí com os gestores de empresas familiares ao proporciona insights sobre a influência da participação dos membros da família no conselho de administração e como isso está atrelado a flexibilidade estratégica.
A Nanocarrier Enhances the Anti-Liver Cancer Efficacy of Mitoxantrone: An Acidic Panax notoginseng Polysaccharide III
Authors: Ding Yuzhen , Wei Panpan , Xia Die , Deng Mengyue , Zhang Yingxi , Li Menglian , Chen Tong , Yan Zijun 
Published: February 2025

Introduction:
The incidence and mortality rates of liver cancer are high; therefore, developing
new drug delivery systems with good biocompatibility and targeting has become a research
hotspot.

Methods:
Mitoxantrone hydrochloride (MH) loaded in acidic Panax notoginseng polysaccharide III
nanoparticles (MANPs) was prepared using electrostatic adsorption. This was achieved by loading
MH in acidic Panax notoginseng polysaccharide III (APPN III), a natural compound that exhibits
anti-tumor activity. Response surface methodology was used to determine the parameters for the best
formulation.

Results:
Fourier-transform infrared spectroscopy and differential scanning calorimetry indicated that
MH in MANPs was amorphous and exhibited good encapsulation efficiency in the carrier. Findings
from dynamic dialysis confirmed that MANPs exhibited slow drug release at pH 6.8 and over the pH
range of 7.2-7.4. In vitro experiments confirmed the anti-tumor effects of MANPs on H22 cells based
on the inhibition of cell proliferation and an increase in apoptosis. MANPs also demonstrated an obvious
anti-tumor effect without any toxicity in H22 tumor-bearing mice. This effect could be attributed
to APPN III enhancing the immune system and exerting a synergistic anti-tumor effect in combination
with MH, thereby alleviating MH-induced damage to the immune system in H22 tumorbearing
mice.

Conclusion:
As a nano-carrier prepared using natural resources, APPN III shows immense potential
in the field of drug delivery and could serve as a novel option for the effective delivery of chemotherapeutic
drugs.
Tumor-Associated Pericytes: Tumorigenicity and Targeting for Cancer Therapy
Authors: Tan Jiale , Yu Zihang , Pi Ruozheng , Lin Yan , Wang Wei , Chen Minfeng , Bai Xue 
Published: February 2025

Abstract:
Pericytes, also known as mural cells, are cells embedded between endothelial cells and the
basement membrane of capillaries, where they orchestrate the morphological and functional homeostasis
of blood vessels. Within the tumor microenvironment, pericytes interact closely with various
cellular components, including tumor cells, stromal cells, and immune cells. Through these dynamic
interactions, pericytes are activated and subsequently transform into tumor-associated pericytes
(TPCs). The origin of TPCs varies depending on the tissue and tumor type, contributing to their phenotypic
and functional heterogeneity. TPCs play pivotal roles in facilitating tumor progression, metastasis,
immune evasion, and therapeutic resistance by promoting angiogenesis, engaging in reciprocal
interactions with tumor cells, remodeling the extracellular matrix, and fostering an immunosuppressive
microenvironment. This review synthesizes the latest significant advancements in targeted
therapies against TPCs. It underscores the challenges inherent in developing effective anti-TPC therapies,
which include the heterogeneity and pluripotency of TPCs, the absence of specific markers for
precise TPC targeting, and the limited understanding of how current anti-tumor therapies affect TPCs
and vice versa. This review furnishes a comprehensive understanding of the origins, markers, and
functions of TPCs, and their interplays within the tumor microenvironment, providing prospective
strategies for more effective anti-tumor therapy.
The Effect of Chrysin Nanocrystal on the Thyroid Gland of Rats Exposed to Chlorpyrifos
Authors: Farkhondeh Tahereh , Ahrari Fatemeh , Rajabi Shahnaz , Alemzadeh Effat , Mesbahzadeh Behzad , Rezaei Maryam , Ziafati Majidi Sara , Samarghandian Saeed 
Published: February 2025

Background:
Chlorpyrifos (CPF) is an organophosphate insecticide that is mostly used
in agriculture for pest control.

Aim:
This investigation aimed to evaluate the possible protective role of chrysin nanocrystals on
thyroid gland hormones and histology in male rats after exposure to a high dose of chlorpyrifos.

Method:
Rats were randomly divided into 6 groups (6 rats in each group): 1. healthy control
group, 2. treated with chrysin nanocrystal (5 mg/kg), 3. treated with chrysin nanocrystal (10
mg/kg), 4. treated with chrysin nanocrystal (5 mg/kg) + chlorpyrifos, 5. treated with chrysin
nanocrystal (10 mg/kg) + chlorpyrifos, and 6. treated with chlorpyrifos (30 mg/kg). After 15 days
of intervention, rats were anesthetized, and blood samples were taken from the heart to measure
thyroid hormones. Then, the thyroid gland was isolated and stored in 10% formalin for histopathological
studies. Thyroid samples were also stored at -80 ° C for measuring oxidative stress parameters.

Result:
A significant reduction was observed in the serum concentrations of T3 and T4 in all treated
groups compared with the control group (p < 0.01). In addition, hormone level examination revealed
no statistically significant (p ˃ 0.05) changes in plasma TSH concentration in any of the
groups. The treatment with CPF and chrysin nanocrystal did not affect the levels of oxidative biomarkers
(MDA, GSH, and NO) in thyroid glands. Photomicrographs of a histological section of
the thyroid gland showed vacuolar degenerated follicle epithelium and missing colloids in the histological
section of the thyroid gland of all groups.

Conclusion:
Our findings demonstrated that the oral administration of chrysin nanocrystals could
not inhibit the toxic effect of a high dose of CPF on the thyroid gland in the rats.
Health-Promoting Lifestyle and its Predictors among Students of the University of Elbasan, Albania: A Cross-sectional Study
Authors: Kapaj Armela , Gaxhja Elona , Bani Blerina , Gugu Mitilda 
Published: February 2025

Background
Health-promoting lifestyles play a crucial role in improving overall well-being and preventing non-communicable diseases. University students, during their transition to adulthood, often face challenges in maintaining healthy habits due to lifestyle changes, academic demands, and social pressure. Despite their importance, little is known about the adoption of health-promoting behaviors among Albanian university students. This study seeks to investigate the predictors that influence the health-related lifestyle among students at the University of Elbasan “Aleksandër Xhuvani” in Albania.

Methods
A cross-sectional study was conducted among 1,068 students at the University of Elbasan Aleksander Xhuvani, Albania, using the Health-Promoting Lifestyle Profile II (HPLP-II) questionnaire. Data were analyzed using SPSS Version 27.0, employing descriptive statistics, t-tests, and multiple regression analyses.

Results
The overall mean HPLP-II score was moderate at 129.18 ±19.617, with spiritual growth scoring the highest at 26.74 ± 4.736 and physical activity at the lowest at 16.86 ± 4.730. Physical activity (β =-0.33, p<0.001 and self-perception of full health (β =-0.15, p<0.001) were significant predictors of health-promoting behaviors. Non-health-related students scored higher in nutrition and spiritual growth than their health-related counterparts.

Conclusion
These findings reveal moderate adoption of health-promoting behaviors among Albanian students, emphasizing a need for university-targeted interventions. Programs focusing on enhancing physical activity and stress management, tailored to the student's socio-cultural context, are recommended to improve health outcomes.
Advances in Human Brain Organoids: Methodological Innovations and Future Directions for Drug Discovery
Authors: Kanupriya Kanupriya , Pal Verma Suraj , Sharma Vikram , Mishra Isha , Mishra Raghav 
Published: February 2025

Background:
Understanding the genetic foundations of brain development has been
made possible by the use of traditional biological models. However, these models frequently fail
to capture the complexity of human brain development, particularly the considerable cortical expansion
that sets humans apart from other vertebrates and non-human primates.

Objectives:
The purpose of this review is to outline the methodology, applications, and potential
prospects for using human brain organoids as sophisticated models for researching brain development
and illness mechanisms.

Methods:
Organoids, or three-dimensional (3-D) structures, are generated by utilizing adult or embryonic
stem cells to mimic the main structural and functional features of the human brain. The
present investigation emphasizes the advantages of these organoids over traditional two-dimensional
(2-D) monolayer models in relation to cellular variety and the ability to create complex 3-D
networks, addressing various methods established by researchers to culture these cells.

Results:
Organoids precisely mimic numerous features of human brain development, overcoming
the limitations of conventional models. They have demonstrated significant utility in investigating
the mechanisms that contribute to neurodegenerative diseases like Parkinson’s and Alzheimer’s,
in addition to tumor biology, providing a valuable understanding of both the normal physiological
processes and the underlying cause of the human brain.

Conclusion:
Human brain organoids signify a notable progression in the field of neuroscience research,
facilitating enhanced modeling of brain disorders. Future investigations will further enhance
these methodologies and examine their applications, leading to innovative therapeutic strategies
and broadening the knowledge of human brain disorders.
Perceptions and Earliest Experiences of Medical Students and Faculty With ChatGPT in Medical Education: Qualitative Study
Authors: Abouammoh Noura , Alhasan Khalid , Aljamaan Fadi , Raina Rupesh , Malki Khalid H , Altamimi Ibraheem , Muaygil Ruaim , Wahabi Hayfaa , Jamal Amr , Alhaboob Ali , Assiri Rasha Assad , Al-Tawfiq Jaffar A , Al-Eyadhy Ayman , Soliman Mona , Temsah Mohamad-Hani 
Published: February 2025

Background
With the rapid development of artificial intelligence technologies, there is a growing interest in the potential use of artificial intelligence–based tools like ChatGPT in medical education. However, there is limited research on the initial perceptions and experiences of faculty and students with ChatGPT, particularly in Saudi Arabia.

Objective
This study aimed to explore the earliest knowledge, perceived benefits, concerns, and limitations of using ChatGPT in medical education among faculty and students at a leading Saudi Arabian university.

Methods
A qualitative exploratory study was conducted in April 2023, involving focused meetings with medical faculty and students with varying levels of ChatGPT experience. A thematic analysis was used to identify key themes and subthemes emerging from the discussions.

Results
Participants demonstrated good knowledge of ChatGPT and its functions. The main themes were perceptions of ChatGPT use, potential benefits, and concerns about ChatGPT in research and medical education. The perceived benefits included collecting and summarizing information and saving time and effort. However, concerns and limitations centered around the potential lack of critical thinking in the information provided, the ambiguity of references, limitations of access, trust in the output of ChatGPT, and ethical concerns.

Conclusions
This study provides valuable insights into the perceptions and experiences of medical faculty and students regarding the use of newly introduced large language models like ChatGPT in medical education. While the benefits of ChatGPT were recognized, participants also expressed concerns and limitations requiring further studies for effective integration into medical education, exploring the impact of ChatGPT on learning outcomes, student and faculty satisfaction, and the development of critical thinking skills.
The Philosophy of Ethnobotany and the Transformation of Jamasan Pusaka Tradition in the Pendopo of Batang District
Authors: Kartika Ema , Wicaksono Harto 
Published: February 2025

The tradition of jamasan pusaka (heirloom washing), or simply jamasan, in Batang District involves various types of plants initsrituals. Plants, as part of the local cultural heritage, play an important role in maintaining the balance of parallelism and interrelationship between macrocosm and microcosm. Over time, this tradition has evolved, and this article aims to explorethe relationship and changes in ethnobotanical knowledge within the jamasan practice. It also analyzeshow the immanent and the transcendental functions of plantsare interpreted. Using a qualitative research method with an ethnographic approach, data were collected through observation, interview, and visual documentation. The study identified 19 types of plants involved in the jamasan tradition. These plants , based on local knowledge, hold immanent and transcendental functions that are important for the continuity of the practice. The plants are categorized into mandatory elementsbased on immanent meaning, symbolic meaning, and non-mandatory elements. Jamasan is not merely the washing of heirlooms, butalso serves as a life guide for living meaningfully. Over time,the tradition has undergone transformations, with shifts from sacred to profane functions and from immanent to transcendental meanings. These changes have reconstructed the practice of jamasan in the present day.
Ateliês do sexo, alcova edênica
Authors: Moreira Wanessa de Góis , Silva Emannuelle Carneiro da 
Published: February 2025

O conluio entre os imperativos da carne e a receptividade da ficção provoca uma tensão, de cunho erótico, capaz de ludibriar o observador, lançando-o numa zona diegética tempestiva, que tampona, ilusoriamente, os buracos impostos pela realidade. A crueza de um alter-ego servo do prazer e os engodos de uma voz narrativa fecenina fornecem o "combustível" para a excitação e, ao mesmo tempo, para o declínio do corpo, o qual, de modo surpreendente, liberta-se dos grilhões do pudor e da inocência. Entrementes, o presente trabalho se infiltrará pelas entranhas de uma das pinturas série Paraíso, um compêndio telas da artista naif Val Margarida, no intento de aproximar, (im)possivelmente, instâncias que insistem em se desencontrar. Nas pinturas da Val Margarida, não à toa, a quebradiça malha que protege o humano, da lascívia que o habita, é, subitamente, desfeita, destruída pelos ataques adocicados de Thânatos, cujos suspiros e impropérios fazem aflorar o incauto Eros, que, impotente, subjuga-se à tortura e à dor. É latente a insurgência de vozes líricas complacentes, que, ora devotam cuidados ao inefável, ora tornam-se agentes que amaldiçoam e praguejam, num movimento de puro êxtase, em que a libido fere a folha, a tinta é abusada e o pincel, deslizando em semânticas, desenha o orgasmo. Seu cunho, herético por excelência, exaure o desejo, sacraliza o encontro fúnebre dos corpos e, sem cerimônia, profana a religiosidade de deuses e mortais. Debalde, a consciência ecoa em desespero, silenciando-se, sem êxito algum perante a efervescência sexual. Para tanto, valemo-nos de afamados e abjetos pesquisadores dos estudos erótico-pornográficos, tais como Georges Bataille e Eliane Robert Moraes.
Fragmentos cortantes e reflexivos do Eu
Authors: Santos Leandro Ferreira dos 
Published: February 2025

Em psicanálise, Otto Rank expõe um trabalho bastante significativo para os estudos da duplicidade do sujeito, uma vez que se vale de filmes e narrativas fantásticas para exemplificar a tese do “duplo”. Assim, o duplo, em literatura, é bastante recorrente, pois se apresenta sob profusos andrajos, porquanto corresponda à própria imagem do protagonista. Nesse corolário, debruçar-nos-emos sobre O homem duplicado (2002), de José Saramago, a fim de esmiuçar a claudicante identidade do personagem Tertuliano, que se conecta ao mundo, esquizofrenicamente, e, por consequência, identifica-se com os pedaços de subjetividade que projeta, inadvertidamente, nos outros, irreconhecíveis em virtude da cegueira racional que o envolve. Na obra, o professor Tertuliano Afonso, após assistir a um vídeo, cujo conteúdo lhe é (in)familiar, funde-se, delirantemente, a uma imagem que lhe é idêntica. Para tanto, recorremos a estudos psicanalíticos que postulam acerca do “duplo”, da esquizofrenia e de outros abalos psicóticos, desenvolvidos, amiúde, em textos de Sigmund Freud, Jacques Lacan e Otto Rank.
Effect of miniscrew-assisted maxillary protraction on width changes in the circummaxillary sutures
Authors: Cho Myung Hyun , Choi Youn-Kyung , Kim Sung-Hun , Kim Seong-Sik , Park Hae Ryoun , Kim Yong-Il 
Published: February 2025

Objectives
To evaluate changes in the width of five circummaxillary sutures after miniscrew-assisted maxillary protraction (MAMP) and to identify which of them are most significantly affected.

Materials and Methods
Cone-beam computed tomography (CBCT) performed before and after MAMP treatment was used to assess the sutural and cephalometric changes in growing patients with skeletal Class III malocclusion (n = 17). CBCT-generated lateral cephalograms were analyzed for skeletal and dental changes. Width changes in the five circummaxillary sutures (frontomaxillary, pterygomaxillary, zygomaticofrontal, zygomaticomaxillary, and zygomaticotemporal) were measured before and after MAMP. Suture widths were measured using ImageJ software on CBCT images. The pre- and post-MAMP mean values of the bilateral width changes were compared. The magnitude of the width changes of the five circummaxillary sutures were ranked to identify the most substantially altered sutures. Statistical significance was determined using the Friedman test.

Results
In the CBCT-generated lateral cephalometric analysis, statistically significant increases were observed in SNA and ANB values, with the most pronounced results seen in overjet (P &lt; 0.05). After MAMP, all five circummaxillary sutures demonstrated a statistically significant increase in width. The zygomaticofrontal, pterygomaxillary, and zygomaticotemporal sutures exhibited significant changes, with the zygomaticofrontal suture showing the greatest increase in width.

Conclusions
Among patients with Class III malocclusion treated with MAMP, the most pronounced width increase was observed in the zygomaticofrontal suture, whereas the frontomaxillary suture exhibited the least change.
Evaluation of Insulin Dosage After the Addition of Tirzepatide Compared With Semaglutide or Dulaglutide in Patients With Type 2 Diabetes
Authors: McKone Delaney B. , Duprey Karolyn S. , Hall Hayley M. , Leonhard Abigail , Schadler Aric , Naseman Kristina W. 
Published: February 2025

OBJECTIVE
The purpose of this study was to evaluate insulin dose requirements after the addition of the dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 (GLP-1) receptor agonist tirzepatide compared with the GLP-1 receptor agonists injectable semaglutide and dulaglutide in people with type 2 diabetes.

RESEARCH DESIGN AND METHODS
This was a retrospective cohort study using chart review of electronic health records to identify patients from a single academic medical center with type 2 diabetes who were initiated on tirzepatide, injectable semaglutide, or dulaglutide from 1 July 2021 to 31 May 2023 while on concomitant insulin therapy (basal with or without bolus or premixed insulin).

RESULTS
A total of 135 patients were included in the study. The median percentage change in insulin requirement was 0% at 4–6 weeks (P = 0.286), −16.67% at 3 months (P &lt;0.001), −51.03% at 6 months (P &lt;0.001), and –58.33% at 12 months (P = 0.013) for the tirzepatide group (n = 45) and 0% at 4–6 weeks, 3 months, and 6 months and −12.50% at 12 months in the combined dulaglutide and semaglutide group (n = 90). Mean change in weight at 6 months was −8.5813 kg in the tirzepatide group and −3.4111 kg in the dulaglutide and semaglutide group (P &lt;0.001). The most commonly reported adverse events in the tirzepatide group were decreased appetite, nausea, and vomiting.

CONCLUSION
In patients with type 2 diabetes who were also on insulin, tirzepatide led to significantly lower insulin requirements after 3, 6, and 12 months of use compared with dulaglutide and semaglutide. Tirzepatide also led to significantly more weight loss compared with dulaglutide and semaglutide and yielded a larger decrease in A1C overall without increasing side effects.
Analysis of Immature Platelet Fraction in Patients with Solid Tumors Undergoing Chemotherapy
Authors: Runtuwene Aliza Virginia Eunike , Abdullah Agus Alim , Arif Mansyur 
Published: February 2025

Thrombocytopenia is a common side effect in patients undergoing chemotherapy. Examination of platelet count parameters alone cannot predict the platelet recovery response. Immature Platelet Fraction (IPF) can be used as an additional parameter to determine the etiology of thrombocytopenia. This study aimed to analyze IPF, and other platelet-related parameters related to the effects of chemotherapy on solid tumor patients. A prospective observational study design involving 35 solid tumor patients undergoing chemotherapy at Dr. Wahidin Sudirohusodo Hospital, Makassar, was carried out from August to September 2023. Platelet-related parameters (PLT, PDW, IPF, AIPF, and MPV) were measured using an automatic hematology analyzer. Kolmogorov-Smirnov, paired T-test, Wilcoxon, and Spearman test were used for statistical analysis. There was a significant difference in mean PLT, IPF, PDW, and MPV (p < 0.05) before and after chemotherapy. There was a positive correlation in differences in IPF, MPV and PDW (p < 0.001) with a strong correlation (r =0.6-0.8). There was a negative difference in IPF and PLT (p=0.068) with moderate correlation (r =0.312). Chemotherapy causes a significant decrease in platelets and a significant increase in IPF. Routine blood tests and IPF are useful for monitoring thrombocytopenia due to the effects of chemotherapy.