bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice
Authors: Singh Vandana , Akash Raut , Chaudhary Gaurav , Singh Rajneesh , Choudhury Soumen , Shukla Amit , Prabhu Shyama N. , Gangwar Neeraj , Garg Satish K. 
Published: February 2022

AbstractInhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling. Polymicrobial sepsis was induced by caecal ligation and puncture (CLP) in mice. mRNA expressions of Notch receptors (Notch1,3) and ligands (Jag1, Dll4), and downstream effector genes (Hey1, MLCK, MYPT1) were assessed by RT-qPCR. Protein level of activated Notch (NICD) was assessed by Western blot and immuno-histochemistry. Isometric tension in isolated aortic rings was measured by wire myography.CLP down-regulated aortic expression of Notch3, Jag1 and Dll4 as compared to control mice. Additionally, the protein level of NICD was found to be lesser in aortic tissue sections from CLP mice. Expression of Hey1 and MLCK were attenuated whereas MYPT1 expression was increased in septic mouse aorta. DAPT pretreatment did not improve CLP-induced vascular hyporeactivity to NA, CaCl2 and high K+ (80 mM), rather significantly attenuated the aortic response to these vasoconstrictors in control mice. Treatment with 1400 W reversed attenuated Notch3 (but not Jag1 and MLCK) expression in septic mouse aorta. In conclusion, sepsis significantly attenuated the Notch (especially Notch3) signaling in mouse aorta along with reduction in contractile gene expression and vasoconstriction response. Further, iNOS/NO pathway was involved in sepsis-induced down-regulation of Notch3 receptor. Thus systemic inhibition of Notch signaling during sepsis may have serious impact on sepsis-induced vascular hyporeactivity.
Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs
Authors: Boonyarattanasoonthorn Tussapon , Kijtawornrat Anusak , Songvut Phanit , Nuengchamnong Nitra , Buranasudja Visarut , Khemawoot Phisit 
Published: February 2022

AbstractA newly standardised extract ofCentellaasiatica(Centell-S) with better water solubility than the previous standardised extract ofC.asiatica(ECa 233) was developed, and pharmacokinetic profiles of bioactive triterpenoids were investigated in beagle dogs. The test substances were administered via intravenous or oral administration with single and multiple doses for 7 days. The concentrations of major bioactive triterpenoids, including madecassoside, asiaticoside, madecassic acid, and asiatic acid, in biological samples were measured by liquid chromatography–tandem mass spectrometry. The dogs in this study showed good tolerability to all test substances, based on the physical appearance and blood chemistry 24 h after dosing. The major bioactive triterpenoids found in systemic blood circulation were madecassoside, asiaticoside, and asiatic acid; the concentration of these components ranged from 1 to 10,000 µg/L after intravenous administration of 1.0 mg/kg Centell-S. Oral administration of 10 and 20 mg/kg Centell-S generated approximately twofold higher plasma levels of both madecassoside and asiaticoside compared with equivalent doses of ECa 233. In addition, there was an accumulation of triterpenoid glycosides after multiple oral administrations of Centell-S for 7 days, while triterpenic acids showed little tendency for accumulation. Beagles had good tolerability to both standardised extracts ofC.asiatica, and showed a similar pattern of bioactive triterpenoids to humans. Centell-S increased oral bioavailability of major triterpenoid glycosides and can be further developed into a phytopharmaceutical product.
Prediction and molecular field view of drug resistance in HIV-1 protease mutants
Authors: Wang Baifan , He Yinwu , Wen Xin , Xi Zhen 
Published: February 2022

AbstractConquering the mutational drug resistance is a great challenge in anti-HIV drug development and therapy. Quantitatively predicting the mutational drug resistance in molecular level and elucidating the three dimensional structure-resistance relationships for anti-HIV drug targets will help to improve the understanding of the drug resistance mechanism and aid the design of resistance evading inhibitors. Here the MB-QSAR (Mutation-dependent Biomacromolecular Quantitative Structure Activity Relationship) method was employed to predict the molecular drug resistance of HIV-1 protease mutants towards six drugs, and to depict the structure resistance relationships in HIV-1 protease mutants. MB-QSAR models were constructed based on a published data set of Ki values for HIV-1 protease mutants against drugs. Reliable MB-QSAR models were achieved and these models display both well internal and external prediction abilities. Interpreting the MB-QSAR models supplied structural information related to the drug resistance as well as the guidance for the design of resistance evading drugs. This work showed that MB-QSAR method can be employed to predict the resistance of HIV-1 protease caused by polymorphic mutations, which offer a fast and accurate method for the prediction of other drug target within the context of 3D structures.
Hunting for open clusters inGaiaEDR3: 628 new open clusters found with OCfinder
Authors: Castro-Ginard A. , Jordi C. , Luri X. , Cantat-Gaudin T. , Carrasco J. M. , Casamiquela L. , Anders F. , Balaguer-Núñez L. , Badia R. M. 
Published: February 2022

Context.The improvements in the precision of the published data inGaiaEDR3 with respect toGaiaDR2, particularly for parallaxes and proper motions, offer the opportunity to increase the number of known open clusters in the Milky Way by detecting farther and fainter objects that have thus far gone unnoticed.Aims.Our aim is to continue to complete the open cluster census in the Milky Way with the detection of new stellar groups in the Galactic disc. We useGaiaEDR3 up to magnitudeG= 18 mag, increasing the magnitude limit and therefore the search volume explored in one unit with respect to our previous studies.Methods.We used theOCfindermethod to search for new open clusters inGaiaEDR3 using a big data environment. As a first step,OCfinderidentified stellar statistical overdensities in five-dimensional astrometric space (position, parallax, and proper motions) using theDBSCANclustering algorithm. Then, these overdensities were classified into random statistical overdensities or real physical open clusters using a deep artificial neural network trained on well-characterisedG,GBP–GRPcolour-magnitude diagrams.Results.We report the discovery of 628 new open clusters within the Galactic disc, with most of them being located beyond 1 kpc from the Sun. From the estimation of ages, distances, and line-of-sight extinctions of these open clusters, we see that young clusters align following the Galactic spiral arms while older ones are dispersed in the Galactic disc. Furthermore, we find that most open clusters are located at low Galactic altitudes with the exception of a few groups older than 1 Gyr.Conclusions.We show the success of theOCfindermethod leading to the discovery of a total of 1274 open clusters (joining the discoveries here with the previous ones based onGaiaDR2), which represents almost 50% of the known population. Our ability to perform big data searches on a large volume of the Galactic disc, together with the higher precision inGaiaEDR3, enable us to keep completing the census with the discovery of new open clusters.
Osteoporose-Management während der COVID-19
Pandemie
Authors: Tsourdi Elena 
Published: February 2022

Abstract
Aim The COVID-19 pandemic has influenced the management of many chronic
conditions including osteoporosis as resources are re-allocated to urgent
care.
Methods This mini-review summarizes the effects of COVID-19 on diagnosis
and management of osteoporosis. Evidence regarding possible effects of
osteoporosis medications on COVID-19 outcomes and the relationship of COVID-19
vaccination to osteoporosis care is reviewed. Finally, initiation and
maintenance of osteoporosis treatment during the pandemic are highlighted.
Results The use of standard procedures for the diagnosis of osteoporosis
and assessment of fracture risk significantly decreased during the COVID-19
pandemic, while the incidence of fragility fractures was mostly unaltered. Both
COVID-19 per se and its treatments are associated with a negative impact on bone
health. Osteoporosis medications do not aggravate the clinical course of
COVID-19, while preclinical data suggests possible beneficial effects of some
therapies. While vitamin D deficiency is clearly associated with a worse
clinical course of COVID-19, evidence of outcome improvement through vitamin D
supplementation is lacking. Osteoporosis treatment should not be generally
discontinued, and recommendations for substituting therapies are available.
Osteoporosis therapies do not interfere with the efficacy or side-effect
profiles of COVID-19 vaccines and should not be stopped or indefinitely delayed
because of vaccination.
Conclusion The diagnosis and management of osteoporosis are challenging
during the COVID-19 pandemic. Osteoporosis medications are safe and effective
and should be continued. Further studies will elucidate the impact of the
COVID-19 pandemic on long-term bone health.
Editorial
Authors: Peters Stefan , Scheer Janik 
Published: February 2022

Liebe Leserinnen und Leser,die positiven Auswirkungen von körperlichem Training auf die Gesundheit sind
mannigfaltig und zu diesem Zweck kommt es bei den verschiedensten Zielgruppen zum
Einsatz. Die Manuskripte, welche regelmäßig zur Publikation in der
Zeitschrift Bewegungstherapie und Gesundheitssport eingereicht werden, reflektieren
diese Vielfalt. Das vorliegende Heft mit seinem bunten Strauß an Themen kann
hierfür als Beispiel dienen.
Akzeptanz und Nutzung eines telemedizinischen
Rehabilitationsprogramms für Patienten mit Knie- oder
Hüft-Totalendoprothese
Authors: Hadzic Miralem , Eichler Sarah , Völler Heinz , Salzwedel Annett ,   Annett Salzwedel für die Arbeitsgruppe ReMove-It
Published: February 2022

Zusammenfassung
Ziel der Studie Die langfristige Nutzung telemedizinischer Angebote
hängt nicht nur von deren Wirksamkeit, sondern auch von der Akzeptanz
und Zufriedenheit der Patienten ab. Für eine telemedizinische
Bewegungstherapie für Patienten nach Implantation einer Knie- oder
Hüft-Totalendoprothese und erfolgter Anschlussrehabilitation wurde die
Wirksamkeit bereits in einer randomisiert kontrollierten Studie untersucht.
Dieser Beitrag fokussiert die Akzeptanz und das Nutzungsverhalten der Patienten
hinsichtlich des eingesetzten telerehabilitativen Systems.
Methodik Zur Erfassung der Technikakzeptanz wurden 48 Patienten
(53±7 Jahre; 26 Frauen; 35 Hüft-/13 Knie-TEP) im
Anschluss an eine dreimonatige telemedizinische Bewegungstherapie mittels des
Telehealth Usability Questionnaire befragt. Der Fragebogen besteht aus 21 Items
(siebenstufige Likert-Skala) in sechs Skalen (z. B.
Nützlichkeit, Qualität der Interaktionen,
Verlässlichkeit). In einer zusätzlichen Skala wurden
systemspezifische Fragen zusammengefasst. Die Ergebnisse wurden als
Skalenprozent (100 ≙ vollkommene Zustimmung)
dargestellt. Das Nutzungsverhalten wurde anhand systemgenerierter Prozessdaten
zum Training sowie zu integrierten Sprach-/Textnachrichten
untersucht.
Ergebnisse Die TUQ-Skalen „Nützlichkeit“ (Mdn 95,2)
sowie „Benutzerfreundlichkeit und Erlernbarkeit“ (Mdn 92,9)
wurden am höchsten bewertet, während die
„Verlässlichkeit“ (Mdn 57,1) und
„Qualität der Interaktionen“ (Mdn 71,4) die geringsten
Ausprägungen zeigten. Die systemspezifische Skala wurde im oberen
Quartil eingeordnet (Mdn 85,7).In der ersten Woche führten 39 Patienten (81%), in der zweiten 45
Patienten (94%) mindestens eine Trainingsübung mit dem System
durch. Der Anteil aktiver Patienten (≥1 Übung/Woche)
reduzierte sich im weiteren Verlauf auf 75% (n=36) in der 7.
Woche und 48% (n=23) in der 12. Woche. Die systemeigenen
Kommunikationsmöglichkeiten wurden nach Therapiestart zunächst
häufig genutzt: in der ersten Woche sendeten 42 Patienten (88%)
Nachrichten, 47 Patienten (98%) erhielten Nachrichten von ihrem
Therapeuten. In der 7. Woche sendeten/erhielten 9 (19%) bzw. 13
(27%) Patienten Nachrichten über das System.
Schlussfolgerung Die Patienten nahmen die telemedizinische
Bewegungstherapie überwiegend als nützlich und
benutzerfreundlich wahr und schienen im Wesentlichen mit dem System zufrieden,
das sich damit für den kurzfristigen Einsatz von 6 bis 8 Wochen im
Anschluss an eine Anschlussrehabilitation als gut geeignet zeigte.
Sensomotoriktraining in der Kinderonkologie – Umsetzung eines
kindgerechten und spielerischen Trainingskonzepts
Authors: Otten Sarah , Bischoff Clémentine , Oschwald Vanessa , Prokop Aram , Maas Volker , Bloch Wilhelm , Streckmann Fiona , Däggelmann Julia 
Published: February 2022

ZusammenfassungBei einem Sensomotoriktraining (SMT), hier konkret einem Gleichgewichtstraining
als Unterform des SMT, werden Übungen auf unterschiedlich stabilen
Untergründen und in verschiedenen Standpositionen durchgeführt.
Es hat das Potenzial, Regenerations- und Anpassungsmechanismen anzuregen und so
zur Plastizität des Nervensystems beizutragen. Das Training
ermöglicht eine individuelle und an die Tagesform angepasste Umsetzung
und zeichnet sich durch einen geringen Material- und Zeitaufwand sowie eine gute
Reproduzierbarkeit aus. Das SMT findet schon lange Anklang in der Rehabilitation
sowie der Verletzungs- und Sturzprophylaxe. In den vergangenen Jahren wurde es
auch vermehrt im Bereich der Erwachsenenonkologie zur Verbesserung der oftmals
weitreichenden therapiebedingten Beeinträchtigungen der unteren
Extremitäten, wie z. B. eine verminderte
Gleichgewichtsfähigkeit, umgesetzt. Auch an Krebs erkrankte Kinder und
Jugendliche sind häufig, u. a. infolge einer
Chemotherapie-induzierten Polyneuropathie (CIPN), von den genannten
Beeinträchtigungen in der unteren Extremität betroffen. Diese
können sie auch noch lange nach der medizinischen Therapie daran
hindern, ausreichend körperlich aktiv zu sein. SMT hat in diesem Kontext
das Potenzial, adäquate sensorische und motorische Voraussetzungen
für ein ausreichendes Aktivitätsniveau zu schaffen.Mit dem Ziel einer kindgerechten, motivierenden und individuellen Umsetzung des
SMT wurde am Departement für Sport, Bewegung und Gesundheit der
Universität Basel ein spezielles Trainingskonzept für die
Kinderonkologie entwickelt. Mit einer Drehscheibe können die Kinder die
Übungen kreativ und spielerisch zusammensetzen und so die Schwierigkeit
individuell an ihre Tagesform nach der Therapie anpassen. Die Umsetzbarkeit des
Trainingskonzepts wurde in einer 4-wöchigen Pilotstudie im Rahmen eines
etablierten pädiatrisch-onkologischen Nachsorgesportprogramms der
Deutschen Sporthochschule Köln im Kinderkrankenhaus Amsterdamer
Straße Köln erprobt. Es nahmen 6 Kinder und Jugendliche teil.
Die vorläufigen Ergebnisse der Pilotstudie und ein Fallbeispiel zeigen,
dass das kindgerechte und spielerische SMT nach einer Krebserkrankung im
Kindesalter ohne Zwischenfälle umsetzbar ist und eine spezifische und
wertvolle Ergänzung der pädiatrisch-onkologischen
Bewegungstherapie darstellen kann.
Leichhardt, land clearing and livestock: the legacy of European agriculture in the Brigalow Belt bioregion of central Queensland, Australia
Authors: Thornton Craig M. , Elledge Amanda E. 
Published: February 2022

Context The Brigalow Belt bioregion of central Queensland has been extensively developed for agriculture since exploration by Leichhardt in 1844. About 4.5 million hectares of vegetation dominated by brigalow (Acacia harpophylla) was cleared as part of the Land Development Fitzroy Basin Scheme, which commenced in 1962. When the Vegetation Management Act 1999 commenced, 93% of brigalow woodland had been cleared. Grazing is the dominant land use in the Fitzroy Basin, with 2.6 million cattle over 11.1 million hectares (72% of the catchment area). This is the largest cattle herd in any natural resource management region in Australia, accounting for 25% of the state herd and 11% of the national herd. Aims The Fitzroy Basin, Queensland’s largest coastal catchment, drains directly to the Great Barrier Reef, and as reef health continues to decline, there has been increased focus on the impacts of land-use change and grazing management on hydrology and runoff water quality. The Brigalow Catchment Study sought to determine the impact of land clearing, land-use change and land management on hydrology, soil fertility, water quality and animal production in the Fitzroy Basin. Methods The study is a paired, calibrated catchment study. Catchment hydrology, soil fertility, water quality and agricultural productivity were monitored before and after land clearing and land-use change. Key results The Brigalow Catchment Study has shown that clearing brigalow for grazing in the Fitzroy Basin doubled runoff, increased peak runoff rate by 50% and increased total suspended solid loads by 80%. Soil fertility and pasture productivity also declined under grazing compared with brigalow. Overgrazing exacerbated these results, as failure to reduce stocking rate with reduced pasture productivity more than tripled runoff, peak runoff rate and total suspended solid load compared with conservatively grazed pasture. Conclusions This study demonstrates the impacts of land-use change and land management on hydrology, soil fertility and water quality. The long-term data records are a model in their own right, capable of answering land-use and land-management questions beyond the initial study scope. Implications Sustainable grazing management should consider the production limitations of depleted soil and pasture resources to minimise land degradation.
Phosphorus fertilisation may induce Zn deficiency in cotton (
Authors: Ipsilantis Ioannis , Theologidou Georgia S. , Bilias Fotis , Karypidou Anna , Kalyvas Apostolos , Tsialtas Ioannis T. 
Published: February 2022

On a P-poor, calcareous soil, three upland cotton (Gossypium hirsutum L.) cultivars (ST 402, ST 405, Zeta 2) were tested for 2 years under three P rates (0, 13.1, 26.2 kg P ha−1). Leaf traits (SPAD values; specific leaf area, SLA; carbon isotope discrimination, Δ; 15N natural abundance, δ15N) and elements (N, P, K, C, Na, Zn) along with arbuscular mycorrhizal (AM) colonisation were measured at first open flower, full bloom and first open boll stages. Phosphorus addition decreased yield, but had no effect on fibre quality, a response attributed to P-induced Zn deficiency, previously reported for cereals. The best-performing cv., ST 405, had high SPAD and SLA, but the lowest P, N and Zn concentrations, an indication of cultivar’s high use efficiency for these nutrients. At full bloom, SPAD was lowest, while SLA was highest. AM increased gradually with growth stages, while N, P, K and Zn concentrations showed an opposite trend, possibly due to a dilution effect. On Mediterranean calcareous soils, P fertilisation should take into account soil Zn levels in order to avoid P–Zn antagonistic relationships, which could impact negatively on yield.
The semiotics of family in Kazakh wedding toasts from the perspective of intercultural communication
Authors: Temirgazina Zifa , Rakhimzhanov Kanat , Akosheva Marzhan , Luczyk Malgorzata , Kulumzhanov Nurzhan , Shaharman Aigerim , Zyuldubayeva Razida 
Published: February 2022

Abstract
This article explores the specifics of the semiosis of family in the Kazakh culture. The approaches of Halliday
and Malinovsky were used to analyze the semiotics of wedding toasts, as well as the method of analyzing the “cultural metaphor” in
Sharifyan’s linguistics. Language units in the texts of Kazakh wedding toasts demonstrate the specific understanding of marriage
and family by the Kazakhs. The language contains “traces” of archaic, sacral, mythological ideas, rituals and traditions of the
Kazakhs. In particular, the semiotics of marriage reflect the idea of a young family as a new home. The semiotic parts of the
Kazakh yurt (shanyrak, kerege, and bosaga) are also sacred signs of marriage, symbolizing
happiness, well-being, wealth, and family safety. This is evidenced by the frequent use of names of the yurt – ak
otau and its components in the speech of the wedding party guests. The cosmogonic concepts ak jaryk,
nur (‘light’, ‘shine’) are important for understanding the semiotics of family. The difficulties in interpreting
wedding toasts arise in the intercultural communication due to Kazakh specific ideas about marriage and family presented in the
non-equivalent units of the language.
Children’s symbolic understanding of a digital, three-dimensional, interactive image (La comprensión simbólica infantil de una imagen digital, tridimensional e interactiva)
Authors: Sartori Mariana , Peralta Olga 
Published: February 2022

Young children increasingly interact with technological devices, either as a form of entertainment or for educational purposes. This research sought to investigate the early symbolic understanding of an interactive, three-dimensional digital image presented on a tablet. Two studies were designed in which the children had to use the image as a source of information to solve a search task. The first study investigated the performance of children aged 30 and 36 months. We found that the children symbolically understood the image at 36 months, but not at 30. The second study investigated the impact of manipulation and instruction on the performance of 36-month-old children. The results showed that the manipulation of the image negatively impacted the understanding of it as a symbol, regardless of the instruction received. The results are interpreted in terms of the impact of manipulation, instruction and the three-dimensionality of the object on understanding it as a symbol. Possible implications in education are also discussed.
Association of cardiac autonomic modulation with different intensities of physical activity in a small Brazilian inner city: A gender analysis
Authors: Christofaro Diego G.D. , Tebar William R. , Vanderlei Luiz Carlos M. , Fernandes Rômulo A. , Mota Jorge , Mielke Gregore I. , Ritti‐Dias Raphael M. 
Published: February 2022

ABSTRACTPhysical activity has been linked to higher cardiac autonomic modulation. However, it is not clear in the literature which type of intensity of physical activity (sedentary, light, moderate, or vigorous) could be related to better cardiac autonomic modulation and whether this relationship is similar in men and women. The aim of this study was to analyze the relationship between cardiac autonomic modulation and the different intensities of physical activity in men and women. The sample included 100 men and 131 women. Cardiac autonomic modulation was obtained by heart rate variability (SDNN, RMSSD, LF un, HF un, SD1, and SD2). Time spent in different intensities (sedentary, light, moderate, and vigorous intensity physical activity) was measured using a waist‐worn accelerometer for seven days. Linear regression was used to verify the relationship between physical activity and cardiac autonomic modulation, considering the adjustment for age, ethnicity, and socioeconomic level. Among men, a significant relationship of moderate intensity was observed with SDNN (β = 2.442; p = 0.021) and SD2 (β = 2.936, p = 0.028), and of vigorous intensity with SDNN (β = 12.826, p = 0.028), RMSSD (β = 16.370, p = 0.018), and SD1 (β = 12.344, p = 0.025) indices. Among women, light‐intensity physical activity was significantly related with LFnu (β = . 655, p = 0.005) and HFnu (β = ‐.590, p = 0.010). Moderate and vigorous physical activity was associated with better cardiac autonomic modulation in men. Light physical activity was associated with lower sympathetic modulation in women.