bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of foliar application of selenium and potassium-humate on oat growth in Baloza, North Sinai, Egypt
Authors: Hegab Rehab H. , Eissa Doaa , Abou-Shady Ahmed 
Published: September 2022

AbstractIn this study, the effects of foliar application of selenium (Se) at different concentrations were examined based on changes in several parameters such as nitrogen, phosphorous, and potassium (NPK) concentration in soil and oat plant, oat yield, organic matter in the soil (OMS), non-enzymatic antioxidants, and total phenol content. Chromium (Cr), iron (Fe), manganese (Mn), zinc (Zn), and copper (Cu) concentrations were also assessed in oat straw and seeds. The study complies with local and national guideline. Simultaneous application of potassium humate (K-humate) with Se was also investigated in this study. Se application increased the bioavailability of N and P in soil and their total concentration in the straw and seeds of each plant. Se concentrations were proportional to the amount of phosphorous found in soil (P-soil) but not with K concentrations in seed (K-plant). Application of K-humate with Se increased the bioavailable fraction of K-soil; however, it did not increase the bioavailable fraction of K-straw or K-seed. Although the application of Se alone substantially enhanced yield, the simultaneous application of K-humate showed no additional effect. Moreover, responses of seed yield and plant length were not significant after the application of Se with or without K-humate. OMS and total phenol content were proportional to the application rate of Se with and without K-humate. Non-enzymatic antioxidant content was also proportional to Se concentrations but not proportional to K-humate. The total Se concentrations in the soil, plant straw, and seeds increased with the addition of K-humate. Furthermore, the total Cr concentrations were reduced after the application of Se and K-humate. Fe concentration in the straw and seeds varied from one treatment to another, and Mn concentration was reduced in response to the foliar application of Se and K-humate. Zn concentrations in the straw and seeds of plants were reduced with the application of varying concentrations of Se. Increasing the application rate of Se induced a reduction in the Cu concentration in seeds. In contrast, the simultaneous application of Se and K-humate increased the Cu concentration in seeds.
Carotenoids improve the development of cerebral cortical networks in formula-fed infant macaques
Authors: Miranda-Dominguez Oscar , Ramirez Julian S. B. , Mitchell A. J. , Perrone Anders , Earl Eric , Carpenter Sam , Feczko Eric , Graham Alice , Jeon Sookyoung , Cohen Neal J. , Renner Laurie , Neuringer Martha , Kuchan Matthew J. , Erdman John W. , Fair Damien 
Published: September 2022

AbstractNutrition during the first years of life has a significant impact on brain development. This study characterized differences in brain maturation from birth to 6 months of life in infant macaques fed formulas differing in content of lutein, β-carotene, and other carotenoids using Magnetic Resonance Imaging to measure functional connectivity. We observed differences in functional connectivity based on the interaction of diet, age and brain networks. Post hoc analysis revealed significant diet-specific differences between insular-opercular and somatomotor networks at 2 months of age, dorsal attention and somatomotor at 4 months of age, and within somatomotor and between somatomotor-visual and auditory-dorsal attention networks at 6 months of age. Overall, we found a larger divergence in connectivity from the breastfeeding group in infant macaques fed formula containing no supplemental carotenoids in comparison to those fed formula supplemented with carotenoids. These findings suggest that carotenoid formula supplementation influences functional brain development.
Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP
Authors: Celik Melih Ö. , Negrete Roger , Di Rosso Riccardo , Machelska Halina , Stein Christoph 
Published: September 2022

AbstractOpioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide (NFEPP) is a novel opioid agonist that preferentially activates opioid receptors at acidic extracellular pH. NFEPP was designed to activate peripheral opioid receptors in injured tissue, therefore precluding side effects elicited at normal pH in brain or intestinal wall. Considering the common combination of opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) in multimodal analgesia, we investigated the interaction between NFEPP and a widely prescribed prototypical NSAID, diclofenac (DCF), in a rat model of unilateral hindpaw inflammation induced by complete Freund’s adjuvant. We evaluated the effects of systemically applied DCF on the paw tissue pH, on the expression of inflammatory mediators in immune cells from inflamed paws and on the expression of opioid receptors in dorsal root ganglia. Additionally, we investigated the antinociceptive efficacy of NFEPP injected into the inflamed paws after DCF treatment. We found that DCF reduced inflammation-induced nociceptive responses and tissue acidosis, but did not change the mRNA expression of IL-1β, TNF-α, IL-6, IL-4, NGF, or of mu-, delta-, or kappa-opioid receptors. The treatment with DCF moderately reduced the antinociceptive efficacy of NFEPP, suggesting a correlation between an increase in local tissue pH and the decreased antinociceptive effect of this pH-sensitive opioid agonist.
Spin filtering effect in all-van der Waals heterostructures with WSe2 barriers
Authors: Zheng Yuanhui , Ma Xiaolei , Yan Faguang , Lin Hailong , Zhu Wenkai , Ji Yang , Wang Runsheng , Wang Kaiyou 
Published: September 2022

AbstractExploiting the spin degree of freedom to store and manipulate information provides a paradigm for future microelectronics. The development of van der Waals (vdW) heterostructures has created a fascinating platform for exploring spintronic properties in the two-dimensional (2D) limit. Transition-metal dichalcogenides such as tungsten diselenide (WSe2) have electronic band structures that are ideal for hosting many exotic spin–orbit phenomena. Here, we report the spin-filtering effect in all-vdW heterostructures with WSe2 barrier. Combining 2D-perpendicular magnetic anisotropy Fe3GeTe2 (FGT) with different thicknesses of WSe2, the FGT/WSe2/FGT spin valve shows distinct charge and spin transport behavior. Moreover, the negative magnetoresistance (−4.3%) could be inverted into positive magnetoresistance (up to +25.8%) with decreasing the WSe2 thickness. Furthermore, we proposed a spin-filtering model based on Δ-symmetry electrons tunneling to explain the crossover from negative to positive MR signal through ab initio calculation. These experimental and theoretical results illustrate the rich potential of the families of TMDC materials to control spin currents in 2D spintronic devices.
Commercialized artemisinin derivatives combined with colistin protect against critical Gram-negative bacterial infection
Authors: Zhou Yonglin , Liu Baichen , Chu Xiuling , Su Jianqing , Xu Lei , Li Li , Deng Xuming , Li Dan , Lv Qianghua , Wang Jianfeng 
Published: September 2022

AbstractThe emergence and spread of themcr-1gene and its mutants has immensely compromised the efficient usage of colistin for the treatment of drug-resistant Gram-negative bacterial infection in clinical settings. However, there are currently no clinically available colistin synergis. Here we identify artemisinin derivatives, such as dihydroartemisinin (DHA), that produces a synergistic antibacterial effect with colistin against the majority of Gram-negative bacteria (FIC < 0.5) without induced resistance, particularly those carrying themcr-1gene. Mechanism analysis reveals the direct engagement of DHA with the active center of MCR-1 to inhibit the activity of MCR-1. Meanwhile, the results from transcriptome and electron microscope analysis show that DHA could also simultaneously affect the flagellar assembly and the energy metabolism of bacteria. Moreover, in the mouse infection models of Gram-negative bacteria, combination therapy shows remarkable treatment benefits, as shown by an improved survival rate, reduced morbidity, alleviated pathological injury and decreased bacterial loading. Due to the generally safe profile of specialized malaria medication administration in humans, artemisinin derivatives are a promising class of multi-target inhibitors on bacterial resistance and virulence that can be used to extend the usage life of colistin and to tackle the inevitability of serious bacterial infection with colistin.
Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease
Authors: Zarkali Angeliki , Luppi Andrea I. , Stamatakis Emmanuel A. , Reeves Suzanne , McColgan Peter , Leyland Louise-Ann , Lees Andrew J. , Weil Rimona S. 
Published: September 2022

AbstractHallucinations are a core feature of psychosis and common in Parkinson’s. Their transient, unexpected nature suggests a change in dynamic brain states, but underlying causes are unknown. Here, we examine temporal dynamics and underlying structural connectivity in Parkinson’s-hallucinations using a combination of functional and structural MRI, network control theory, neurotransmitter density and genetic analyses. We show that Parkinson’s-hallucinators spent more time in a predominantly Segregated functional state with fewer between-state transitions. The transition from integrated-to-segregated state had lower energy cost in Parkinson’s-hallucinators; and was therefore potentially preferable. The regional energy needed for this transition was correlated with regional neurotransmitter density and gene expression for serotoninergic, GABAergic, noradrenergic and cholinergic, but not dopaminergic, receptors. We show how the combination of neurochemistry and brain structure jointly shape functional brain dynamics leading to hallucinations and highlight potential therapeutic targets by linking these changes to neurotransmitter systems involved in early sensory and complex visual processing.
Stochastic population dynamics of cancer stemness and adaptive response to therapies
Authors: Jain Paras , Duddu Atchuta Srinivas , Jolly Mohit Kumar 
Published: September 2022

Abstract
Intratumoral heterogeneity can exist along multiple axes: Cancer stem cells (CSCs)/non-CSCs, drug-sensitive/drug-tolerant states, and a spectrum of epithelial–hybrid–mesenchymal phenotypes. Further, these diverse cell-states can switch reversibly among one another, thereby posing a major challenge to therapeutic efficacy. Therefore, understanding the origins of phenotypic plasticity and heterogeneity remains an active area of investigation. While genomic components (mutations, chromosomal instability) driving heterogeneity have been well-studied, recent reports highlight the role of non-genetic mechanisms in enabling both phenotypic plasticity and heterogeneity. Here, we discuss various processes underlying phenotypic plasticity such as stochastic gene expression, chromatin reprogramming, asymmetric cell division and the presence of multiple stable gene expression patterns (‘attractors’). These processes can facilitate a dynamically evolving cell population such that a subpopulation of (drug-tolerant) cells can survive lethal drug exposure and recapitulate population heterogeneity on drug withdrawal, leading to relapse. These drug-tolerant cells can be both pre-existing and also induced by the drug itself through cell-state reprogramming. The dynamics of cell-state transitions both in absence and presence of the drug can be quantified through mathematical models. Such a dynamical systems approach to elucidating patterns of intratumoral heterogeneity by integrating longitudinal experimental data with mathematical models can help design effective combinatorial and/or sequential therapies for better clinical outcomes.
Untethered near‐field drone‐based antenna measurement system for microwave frequencies using multiple reference antennas for phase and drone location recovery
Authors: Parini Clive G. , Gregson Stuart F. , Brown Anthony K. 
Published: September 2022

AbstractThe simulation of a novel drone‐based near‐field (NF)/far‐field (FF) antenna measurement system enabling the reconstruction of Antenna Under Test (AUT) phase and the true location of the untethered drone using multiple land‐based reference antennas is described. The mathematical approach follows the principle used within Global Positioning System (GPS) position and time recovery. Conceptually, the satellites are replaced by ground‐based reference antennas of known location, the user location is now the drone location and the user clock offset is replaced by the unknown AUT phase radiated at the angle subtended between the AUT and drone location. This addresses the need for drone‐based NF/FF antenna measurement of large in situ VHF/UHF antenna arrays plus the need to measure the installed performance of microwave antennas on structures such as buildings, aircraft and ships. To assess the viability, a computer simulation of the measurement system is constructed and its performance is analysed in terms of the accuracy of reconstruction of the AUT phase and true drone location, as well as the NF/FF radiation pattern accuracy in terms of the equivalent multipath level (EMPL). An example measurement ‘range’, comprising AUT location and six fixed reference antennas, demonstrates a wide AUT operating bandwidth of (0.5–2) GHz, with EMPL < −50 dB over the forward hemisphere.
GIARPS High-resolution Observations of T Tauri stars (GHOsT)
Authors: Gangi M. , Antoniucci S. , Biazzo K. , Frasca A. , Nisini B. , Alcalá J. M. , Giannini T. , Manara C. F. , Giunta A. , Harutyunyan A. , Munari U. , Vitali F. 
Published: September 2022

Aims. In the framework of the GIARPS High-resolution Observations of T Tauri stars (GHOsT) project, we study the accretion properties of 37 classical T Tauri stars of the Taurus-Auriga star-forming region (SFR) with the aim of characterizing their relation with the properties of the central star, with jets and disk winds, and with the global disk structure, in synergy with complementary ALMA millimeter observations.
Methods. We derive the stellar parameters, optical veiling, the accretion luminosity (Lacc), and the mass accretion rate (Ṁacc) in a homogeneous and self-consistent way using high-resolution spectra acquired at the Telescopio Nazionale Galileo with the HARPS-N and GIANO spectrographs that are flux-calibrated based on contemporaneous low-resolution spectroscopic and photometric ancillary observations.
Results. The Lacc–L*, Ṁacc–M* and Ṁacc–Mdisk relations of the Taurus sample are provided and compared with those of the coeval SFRs of Lupus and Chamaeleon I. We analyzed possible causes for the observed large spreads in the relations. We find that (i) a proper modeling in deriving the stellar properties in highly spotted stars can reduce the spread of the Ṁacc–M* relation, (ii) transitional disks tend to have lower Ṁacc at a given M*, (iii) stars in multiple systems have higher Ṁacc at the same Mdisk, (iv) the Ṁacc versus disk surface density has a smaller spread than the Ṁacc–Mdisk, indicating that opacity effects might be important in the derivation of Mdisk. Finally, the luminosities of the [O i] 630 nm narrow low-velocity component and high-velocity component (HVC) and the deprojected HVC peak velocity were found to correlate with the accretion luminosity. We discuss these correlations in the framework of the currently accepted models of jets and winds.
Conclusions. Our results demonstrate the potential of contemporaneous optical and near-infrared high-resolution spectroscopy to simultaneously provide precise measurements of the stellar wind and accretion wind properties of young stars.
Homoeopathic Management of Sub-acute Appendicitis—A Case Report
Authors: Nath Arunava , Palit Deb Kumar , Kundu Nivedita , Lakshmi S. Seetha 
Published: September 2022

AbstractSub-acute appendicitis is a condition where some episodes of acute appendicitis apparently subside spontaneously before they reach the acute stage. A 29-year-old man presented with pain in the right iliac fossa for the last 1 week with periumbilical radiation of pain associated with continual nausea, occasional bouts of vomiting, chill and rigours. Computed tomography scan report suggested a case of sub-acute appendicitis. On the basis of presenting features, the patient was treated with Belladonna and Calcarea carbonica in 30c and 200c (centesimal) potencies, respectively, with repetitions. The patient was under treatment for nearly 6 months with favourable improvement of the generalities along with the underlying pathology. The case was indicative of further studies with adequate sample size in such pathological condition to come to any decisive conclusion.
The Effects of Hysterectomy on Urinary and Sexual Functions of Women with Cervical Cancer: A Systematic Review
Authors: Firmeza Mariana Alves , Vasconcelos Camila Teixeira Moreira , Vasconcelos Neto José Ananias , Brito Luiz Gustavo de Oliveira , Alves Flávio Mendes , Oliveira Natália Maria de Vasconcelos 
Published: September 2022

Abstract
Objective This systematic review aims at describing the prevalence of urinary and sexual symptoms among women who underwent a hysterectomy for cervical cancer.
Methods A systematic search in six electronic databases was performed, in September 2019, by two researchers. The text search was limited to the investigation of prevalence or occurrence of lower urinary tract symptoms (LUTS) and sexual dysfunctions in women who underwent a hysterectomy for cervical cancer. For search strategies, specific combinations of terms were used.
Results A total of 8 studies, published between 2010 and 2018, were included in the sample. The average age of the participants ranged from 40 to 56 years, and the dysfunctions predominantly investigated in the articles were urinary symptoms (n = 8). The rates of urinary incontinence due to radical abdominal hysterectomy ranged from 7 to 31%. The same dysfunction related to laparoscopic radical hysterectomy varied from 25 to 35% and to laparoscopic nerve sparing radical hysterectomy varied from 25 to 47%. Nocturia ranged from 13%, before treatment, to 30%, after radical hysterectomy. The prevalence rates of dyspareunia related to laparoscopic radical hysterectomy and laparoscopic nerve sparing radical hysterectomy ranged from 5 to 16% and 7 to 19% respectively. The difficulty in having orgasm was related to laparoscopic radical hysterectomy (10 to 14%) and laparoscopic nerve sparing radical hysterectomy (9 to 19%).
Conclusion Urinary and sexual dysfunctions after radical hysterectomy to treat cervical cancer are frequent events. The main reported disorders were urinary incontinence and dyspareunia.
Anteromedial Portal versus Transtibial Drilling Techniques for Femoral Tunnel Placement in Arthroscopic Anterior Cruciate Ligament Reconstruction: Radiographic Evaluation and Functional Outcomes at 2 Years Follow-Up
Authors: Gabr Ayman , Khan Mohsin , Kini Sunil G. , Haddad Fares 
Published: September 2022

AbstractThe aim of this study was to compare the functional and radiographic outcomes of arthroscopic single-bundle anterior cruciate ligament reconstruction (ACLR) using either the anteromedial (AM) portal technique or transtibial (TT) technique. We identified 404 patients who underwent arthroscopic ACLR by a single surgeon between January 2006 and December 2016 at our institution. The TT portal was utilized in femoral tunnel drilling in 202 patients (TT group) while the AM portal was used in 202 patients (AM group). The mean postoperative follow-up duration was 26 months (range: 24–33 months). Postoperative radiographic femoral and tibial tunnel positions were assessed by two independent observers. Functional outcomes were evaluated with Tegner, Lysholm, and Knee Injury and Osteoarthritis Outcome score (KOOS) scores. On the anteroposterior plain radiographs, the mean femoral tunnel position relative to the lateral femoral condyle was 46.8% for the AM group versus 48.6% in the TT group, respectively (p=0.003). The mean graft inclination angle was 31.9° and 22° in the AM and TT groups, respectively (p<0.0001). On the lateral radiographs, the mean femoral tunnel placement across Blumensaat's line in relation to the anterior femoral cortex was 84% in the AM group while it was 78% in the TT group (p<0.0001). At 2 years postoperatively, there were no significant differences in the mean Tegner, Lysholm, and KOOS scores between the two patient groups. The graft failure rate at 2 years follow-up was 4.5% (n=9) in the AM group while it was 2.5% (n=5) in the TT group (p=0.2). Femoral tunnel placement was more anatomical with the AM portal technique compared with the TT technique. However, there was no significant difference in postoperative functional outcomes between the two patient groups. The AM portal technique appears to have a higher graft failure rate. This might be attributed to increased graft loading in an anatomical position.
Hemostatic Effects of Tranexamic Acid in Cesarean Delivery: An Ancillary Study of the TRAAP2 Study
Authors: Roullet Stéphanie , Rivoire Timothée , Houssin Clémence , Labrouche Sylvie , Paquin Sandrine , Nouette-Gaulain Karine , Deneux-Tharaux Catherine , Amiral Jean , James Chloé , Sentilhes Loïc 
Published: September 2022

Background Fibrinolysis activation during delivery contributes to postpartum hemorrhage (PPH). Clot lysis time studied with the global fibrinolytic capacity device (GFC/LT) is a functional test which rapidly assesses fibrinolytic profile. Tranexamic acid (TXA) is an efficient antifibrinolytic therapy.
Methods We prospectively studied fibrinolysis and coagulation in 33 women included in the TRAAP2 trial, which aimed to assess the impact of TXA in preventing PPH following a cesarean delivery. TXA or placebo was randomly administered after childbirth as part of the TRAAP2 trial's protocol. Fibrinolytic (GFC/LT, plasma concentration of fibrinolysis activators and inhibitors) and hemostatic parameters were assayed at three sample times (TREF [T-reference] after anesthesia, T15 and T120minutes after TXA, or placebo administration).
Results All cesarean deliveries were elective. In the placebo group, the clot lysis time assessed with GFC/LT significantly decreased between TREF and T120, indicating an activated fibrinolysis (44 [interquartile range, IQR: 40–48] vs. 34 [IQR: 30–36] minutes, p<0.001). In both TXA and placebo groups, significant fluctuations of the plasmatic concentrations of fibrinolytic mediators were noticed over time, suggesting fibrinolysis activation. Clot lysis time measured by GFC/LT was significantly increased in women of the TXA group as compared with those in the placebo group at T15 (120 [120–120] vs. 36 [34–41] minutes, p<0.001) and T120minutes (113 [99–120] vs. 34 [30–36] minutes, p<0.001) after drug administration, indicating a decreased in fibrinolysis in those women.
Conclusion GFC/LT evidenced fibrinolysis activation during cesarean delivery, linked to a decrease in fibrinolytic inhibitors. GFC/LT revealed a significant antifibrinolytic effect of TXA compared with placebo.