bluuebunny/crossref_metadata_2025_split huggingface dataset:
Producción de semilla de variedades de Moringa oleifera Lam según densidad de siembra y cosechas sucesivas
Authors: Ledea-Rodríguez J. L. , Benítez-Jiménez D. G. , Nuviola-Pérez Y. , Wrigth-Ramírez J. V. , Rubio-Sanz Laura 
Published: December 2022

Introducción. Moringa oleifera Lam. es un árbol caducifolio de crecimiento perenne ontogenérico al crecimiento de las arbustivas. Moringa es el único género de la familia Moringaceae, los principales estudios de la especie olerifera se centran en la producción de forraje y muy pocos en la producción de semillas. Objetivo. Evaluar densidades de siembra y cosechas sucesivas para la producción de semillas de variedades de M. oleifera Lam, en un ecosistema degradado por la sequía estacional en Valle del Cauto, provincia Granma, Cuba. Materiales y métodos. El estudio se desarrolló del 2016 al 2018 en bancos de semillas de la Estación Experimental de Pastos y Forrajes (20º 27´ 52,1” N 76º 40’47” O) del Instituto de Investigaciones Agropecuarias “Jorge Dimitrov”, Cuba, mediante un diseño de bloques al azar en arreglo factorial con cuatro repeticiones, para un total de 64 tratamientos resultantes de la combinación entre densidad de siembra (4), variedades de M. oleifera (4) y número de cosechas (4). Las variables consideradas fueron: número de semillas por fruto, número de frutos por planta, longitud de frutos, peso de 100 semillas y rendimiento de semillas. Resultados. La variedad Criolla y Supergenius fueron las de mayor producción de semillas (p≤0,01) (0,67 y 0,71 t ha-1, respectivamente), en la segunda cosecha en julio de 2017, respecto al resto de las cosechas y variedades en estudio. La variedad Supergenius aportó los mayores valores en el número de semillas/fruto, número de frutos/planta y longitud de los frutos/planta con 18,23, 32,08 y 49,18 cm, respectivamente. Conclusión. Las variedades de M. oleifera en estudio no tuvieron diferencias en el potencial de producción de semillas, la densidad de siembra no tuvo efecto, solo la realización de cosechas sucesivas cada seis meses condicionó una diferenciación en la producción de semillas.
pandemia Covid-19 y los retos frente a la responsabilidad civil de los profesionales de la salud
Authors: Galán Camargo Viviana 
Published: December 2022

Tema y alcance: se hace una reflexión acerca de los desafíos que la pandemia ha generado en el tema de la responsabilidad civil médica. En función de la normativa, se determinan los posibles supuestos en los cuales los profesionales de la salud o los establecimientos de salud incurrirían en un caso de responsabilidad civil dentro de este contexto de la covid-19.Características: al tratarse de enfermedades nuevas, los principios de la responsabilidad por culpa evitarán que los prestadores médicos sean condenados por hechos o circunstancias que no se hubieran podido prever o evitar según el estado de los conocimientos de la ciencia. Además, en cuanto al problema de salud pública, todo juicio de responsabilidad deberá tomar en cuenta los cambios que se producirán en la lex artis médica y diferenciar la eventual responsabilidad de los prestadores de salud de aquella que corresponda a la autoridad encargada de controlar los efectos de la pandemia.Hallazgos: como todo lo nuevo es desconocido, la covid-19 fue y será un proceso de aprendizaje en todos los campos.Conclusiones: la emergencia sanitaria provocada por el coronavirus evidencia que los regímenes de responsabilidad deben ser capaces de diferenciar los instrumentos conceptuales disponibles para lidiar con una enfermedad nueva que, además, devino en pandemia.
Design and implementation of an efficient model for the transformation and use of organic solid urban waste
Authors: Vasquez Aguilar Yasira Helena , Ruiz Martínez Lida Esperanza , Serna Caicedo Jesús Alberto 
Published: December 2022

Introduction: This article is the development of the "Design and implementation of an efficient model for the transformation and use of organic solid waste", in the “El Conjunto Residencial de Ontario in Bogotá. (Colombia)”.
Problem: The accumulation of solid urban waste by the residential community shows an environmental problem that results in health problems, bad odors, the attraction of rodents and a poor physical appearance in the common areas of this complex, caused by the lack of use of this organic waste.
Objective: formulate an efficient model for the transformation and use of organic solid waste in the “Conjunto Residencial Tejar de Ontario”.
Methodology: Characterization by the method of quartering and use of organic waste through the design of a micro composting plant.
Results: Physical properties such as color, odor and texture are recognized as well as chemical parameters such as C / N, pH and humidity, with these tools we obtain a good quality and fertile compost.
Conclusion: The transformation of urban organic solid waste is an effective way of mitigating the environmental impact caused by not using it and simultaneously preventing this waste from reaching landfills.
Originality: This transformation and use design was carried out for the first time in the “Conjunto Residencial Tejar de Ontario”, it also contains management strategies that allow optimizing the composting operation.
Limitations: Find tools that are easily understood by the community to strengthen knowledge of recycling, source separation and composting.
Long-term oncological outcomes of organ-sparing treatment of patients with early breast cancer aged 65 years and older who had no postoperative radiation therapy
Authors: Ortabaeva D.  R. , Zikiryakhodzhaev A. D. , Rasskazova E. A. , Saribekyan E. K. , Kaprin A. D. 
Published: December 2022

Postoperative radiation therapy after breast-conserving surgery is a standard method of treating breast cancer, but recently the issue of its de-escalation in patients older than 65 due to concomitant pathology, lower life expectancy and possible development of post-radiation complications has been discussed. The results of some foreign studies prove the absence of a statistically significant difference in relapse-free and overall survival in patients with early breast cancer older than 65 years with relatively favorable clinical and morphological characteristics without postoperative radiation therapy. We analyzed the long-term oncological results in patients with breast cancer older than 65 years after breast-conserving surgery without postoperative radiation therapy. The results of the study showed that postoperative radiation therapy in patients over 65 years of age with stage IA pT1N0M0 breast cancer of luminal immunophenotype A does not improve long-term oncological indicators. Thus, the exclusion of postoperative radiation therapy from the treatment plan of this group of patients is oncologically safe and economically justified.
Accuracy of core biopsy image-guided post-neoadjuvant chemotherapy breast to predict pathologic complete response
Authors: Krivorotko P. V. , Mortada V. V. , Pesotskiy R. S. , Artemyeva A. S. , Emelyanov A. S. , Ereshchenko S. S. , Dashyan G. A. , Amirov N. S. , Tabagua T. T. , Gigolaeva L. P. , Komyakhov A. V. , Nikolaev K. S. , Mortada M. M. , Zernov K. Yu. , Zhiltsova E. K. , Smirnova V. O. , Bondarchuk Ya. I. , Enaldieva D. A. , Novikov S. N. , Busko E. A. , Chernaya A. V. , Krzhivitskiy P. I. , Paltuev R. M. , Semiglazova T. Yu. , Semiglazov V. F. , Belyaev A. M. 
Published: December 2022

Background. Achieving a pathologic complete response (pCR) after neoadjuvant systemic therapy (NST) is a predictive factor for improving disease free and overall survival. In triple negative (TN) and HER2-positive breast cancer (BC), the pCR rate exceeds 60 %. Patients with TN and HER2-positive BC who demonstrate an excellent response to NST are like­ly ideal candidates for downsizing surgery. The condition for reducing the volume of surgical intervention is a reliable determination of pathologic complete response using instrumental imaging and biopsy methods.Aim. To further assess the accuracy of post-NST image-guided biopsy to predict pCR.Materials and methods. Sixty one patients with T1-3N0-3 triple negative or HER2-positive BC receiving NST in the Department of Breast Tumors of the NMRC of Oncology named after N.N. Petrov in the period from 2017 to 2019 were enrolled in this single-center retrospective trial. Patients underwent ultrasound-guided core-biopsy of the initial breast tumor region before surgery. Findings were compared with findings on pathologic evaluation of surgical specimens to determine the performance of biopsy in predicting pCR after NST.Results. After neoadjuvant systemic therapy, clinical partial response (cPR) was diagnosed in 47 (77 %) patients, clinical complete response (cCR) in 14 (23 %) patients. pCR in the core-biopsy tissue and surgical material was achieved in 46 (75.4 %) and 37 (60.7 %), respectively. Performance of image-guided core-biopsy: sensitivity 100 % (95 % confldence interval (CI) 90.51-100), specificity 62.5 % (95 % CI 40.59-81.20), false-negative rate (FNR) 0 %, positive-pre­dictive value (PPV) 75.00 % (95 % CI 59.46-85.99), negative predictive value (NPV) 100.00 %.Conclusion. This retrospective trial showed that ultrasound-guided core biopsies are accurate enough to identify breast pCR in patients with triple-negative or HER2-positive BC with good response after NST (FNR 0 %). Based on these results, a prospective clinical trial has commenced in which breast surgery is omitted in patients with a breast pCR after NST according to image-guided biopsy.
MicroRNA-dependent mechanisms of taxane resistance in breast cancer
Authors: Apollonova V. S. , Sidina E. I. , Tkachenko E. V. , Malek A. V. 
Published: December 2022

Breast cancer (BC) has a leading position in the statistics of oncological morbidity and mortality among women. Taxan-based polychemotherapy regimens are an essential component of the complex therapy of the BC. However, currently used algorithms of taxan-based regimens application do not always provide with desire effect. It indicates the need to identify new prognostic markers and to develop new approaches to modify response of BC cells to standard therapeutic regimens. MicroRNAs, small RNA molecules regulating protein synthesis, are considered as promising markers and potential modulators of the BC cells sensitivity to taxanes.The review includes a brief summary of the molecular mechanisms of action of the taxanes and the mechanism BC resistance to the process of microtubules depolymerization, provides with analysis of recent experimental and observational studies of the role of microRNAs in control of these mechanisms, and evaluates prospects for the development of new approaches to predict and to improve the cytostatic effects of taxanes through the analysis and modification of cellular microRNAs.
Malignant transformation of endometrial hyperplastic processes: immunohistochemical features
Authors: Sobivchak M. S. , Protasova A. E. , Raskin G. A. , Mukhina M. S. , Kaurtseva A. S. 
Published: December 2022

Background. Endometrial hyperplasia is one of the most common pathologies of the female reproductive system. There is a high risk of transformation of an atypical form of endometrial hyperplasia into endometrial cancer, which takes a leading position in oncogynecological morbidity. Immunohistochemical markers can become predictors of endometrial malignancy, their role is currently being actively studied.Aim. Search for molecular predictors of malignant transformation of endometrial hyperplasia.Materials and methods. Histological and immunohistochemical studies were performed in 107 patients with diagnoses of endometrial hyperplasia without atypia (EH), endometrial atypical hyperplasia (EIN), endometrioid adenocarcinoma (EC). The tumor receptor status, MSI, expression of ARID1A, PTEN, β-catenin, PAX2, proliferation index (Ki-67) were determined by the immunohistochemical method according to the standard protocol.Results. Loss of PAX2 expression was most common in precancerous and malignant endometrial cells. Loss of PAX2 expression was found in 89 % of cases in the EIN samples, in 86 % of cases in the EC samples and only in 2 cases of EH. Loss of PTEN expression was less common: with an equal proportion in 67 % of the samples of EIN and EC, while practically not occurring in women with benign GE. MSI was detected in 36 % of endometrial cancer samples. There was a deficiency in the DNA repair system in 1 case of EIN. Loss of ARID1A expression was detected in endometrial cancer with a frequency of 33 %. This gene functioned normally in all cases of EIN and EH. The expression of β-catenin was more pronounced in EC than in cases of EH. The Ki-67 proliferation index was statistically higher in the EC group than in EH and EIN.Conclusion. Evaluation of morphological data and expression of the panel of markers PAX2, PTEN, ARID1A, β-catenin, Ki-67 index, PMS2 and MLH1 will improve diagnostic search in case of suspected malignancy of endometrial hyperplasia.
Mental foramen of mandible in South Kerala population - A digital radiographic study
Authors: Mahadoon Nivia , Sivakumar R , Padmakumar S. K , Rajasekharan Asish , Binu Jeffy , Anu Andrews 
Published: December 2022

To assess whether there is sexual dimorphism in the location of mental foramen from base of mandible in South Kerala population.A two-year retrospective study was conducted in 200 subjects [100 males and 100 females] using digital radiographs. The location of mental foramen mandible was assessed from digital orthopantomogram. The vertical distance was measured from the superior border of the mental foramen to the lower border of the mandible and the inferior border of the mental foramen to the lower border of the mandible. The obtained data statistically analyzed using SPSS software version 20. Descriptive statistics was analyzed. Independent t-test was done to determine the association between gender and different parameters. The level of significance set at p ≤ 0.05.The average value of the distance of lower border of mandible from the superior and inferior border of mental foramen is found to be significantly higher in males than females.The study revealed that there is sexual dimorphism in the location of mental foramen in South Kerala population.
Prediction of osteoporosis in men and women through orthopantomograph
Authors: Patel Priyanka Bipin , Dave Riya Divyakant , Patel Twinkal Shileshbhai , Patel Purv , Dudhia Bhavin , Bhatia Parul 
Published: December 2022

Osteoporosis is a systemic disease characterized by low bone mineral density, deterioration of bone structure and increased bone fragility most commonly seen in females of old age as a result of lack of estrogen. The mandibular cortical index, observed on panoramic radiograph, is useful for the screening of osteoporosis. The aim of the study is to study and analyze thickness of mandibular cortical bone on orthopantomography as a representative for the preliminary diagnosis of osteoporosis. The study was conducted on 100 subjects orthopantomographs which included both males and females of all ages. Patients with prior systemic diseases were not included. There were 50% males and 50% females in the age group of 21-90 with 43% in group 1 patients with all teeth, 57% in group 2 patients with few or no teeth. Group 1 had 60.5% males and 39.5% females, Group 2 had 42.1% males and 57.9% females. C1 had 43%, C2 42% and C3 15%. C1 had 52% males, 42% females, C2 had 48% males, 36% females, C3 had 30% females, 0% males. There is relevant relation between age, gender and osteoporosis. With increased age there is decreased oral health seen in both males and females of middle aged. Due to decreased levels of estrogen in females they are more likely to develop osteoporosis. Use of radio morphometric indices on OPG can predict osteoporosis. There are high chances of osteoporosis in females than males.
Knowledge Improvement of Xerosis Cutis through Health Education in the Elderly
Authors: Damayanti  , Astindari  , Indranarum Trisiswati , Mappamasing Hasnikmah , Hadiwidjaja Farsha Naufal , Axelia Presstisa Gifta 
Published: December 2022

Background: Xerosis cutis presents in more than 50% of the elderly population and is currently the most common complaint related to a skin condition in the elderly population. However, many of them are still uninformed of this complaint. Education plays an important role in the management of xerosis cutis, such as how to identify and avoid triggering factors and how to break the itch-scratch cycle. Purpose: This study aims to evaluate the level of knowledge on xerosis cutis in the elderly population after receiving health education. Methods: This observational study involved 71 subjects who met the inclusion criteria of being elderly and were willing to participate in this study. The data were collected using questionnaires. The level of knowledge was assessed before and after the health education around xerosis cutis. Result: Eleven (15.49%) male and 60 (84.51%) female subjects participated in this study. There was a significant difference mean scores between the pre-test and post-test after health education (p= <0.001). The means of total scores of the pre-test and post-test were 11.72 ± 1.475 and 12.58 ± 1.662. The questionnaire consisted of chapters regarding skin changes in the elderly, risk factors for xerosis cutis, and management of xerosis cutis. A significant difference in score between the pre-test and post-test was found in all the chapters (p=0.046, p=0.002, and p=0.006). Conclusion: Following health education, there was an improvement in the elderly's level of knowledge on xerosis cutis.
Pediatric Viral and Bacterial Skin Infection Profile
Authors: Dimawan Rully Setia Agus , Prakoeswa Flora Ramona Sigit , Pramuningtyas Ratih 
Published: December 2022

Background: Viral and bacterial skin infection is a common condition amongst children. In developing countries, it is a complex major health problem. However, epidemiological study on viral and bacterial skin infection in the pediatric population is still lacking, especially in Indonesia. Purpose: This study aimed to evaluate bacterial and viral skin infection amongst children and its association with age and sex. Methods: This study used a cross-sectional design with a retrospective approach. We retrieved medical records of pediatric patients admitted to Dr. Harjono S Ponorogo General Public Hospital between 2016 and 2020. Result: Of the 1,427 collected medical records, we found that the viral infection prevalence was 4.9% (n=70) and 7.5% (n= 107) for bacterial skin infection. Viral infection was most observed amongst subjects in the >12-year age group and 2–12-year for bacterial infection. Infection was more commonly observed amongst boys. Conclusion: The skin infection prevalence in Dr. Harjono S. Ponorogo General Hospital is lower compared to other studies. Skin infection of viral origin was most reported in children aged >12 years and bacterial infection in children aged 2–12. Both skin infections were more commonly observed in boys than girls.
Preparation of [Fe(paptH)2] (CF3SO3)2 and [Fe(paptH)2] [Fe(CN)5NO] (paptH = bis(2-(pyridin-2-ylamino)-4-(pyridin-2-yl)thiazole: Magnetic, Mössbauer, and Electronic Spectral Properties
Authors: Sugiyarto Kristian Handoyo , Goodwin Harold Andrew 
Published: December 2022

Complexes of [Fe(paptH)2][X]2.nH2O, (paptH = 2-(pyridin-2-ylamino)-4-(pyridin-2-yl)- thiazole, X = CF3SO3 and n = 1.5, and X2 = [Fe(CN)5NO] and n = 3) have been characterized in magnetic, Mössbauer, and electronic spectral properties. The studies reveal that the two complexes are predominantly quintet state at room temperature, but singlet at low temperature (below 91K). The change is assigned as a thermally spin state transition, singlet 1A1g (LS, low-spin) ↔ quintet 5T2g (HS, high-spin), in iron(II), being gradual, continuous, and incomplete at the experimental temperature range, and without hysteresis in these instances. The two complexes were yellowish brown at room temperature (~ 298K) but darkening to reddish brown at the lower temperatures.
Subjective Meaning of Strategic Pricing Decision Making based on Islamic Values in the Muslim Business community
Authors: Junaedi Wahyu , Prihanisetyo Adi 
Published: December 2022

<p><em>Fierce competition in business often encourages businesses to act unreasonably in their pricing strategies. Orientation to maximum profit often trumps the ethical values derived from religious teachings. This study aims to find the meaning of strategic pricing decision-making of Muslim businessmen based on their awareness of Islamic values. Islamic values arise from the perception of business people as a reflection of knowledge about Islamic ethics that they understand. The research method used is transcendental phenomenology. The sampling was conducted on five businesspeople members of the Indonesian Islamic Business Forum (IIBF). This study found that Muslim businessmen Interpret strategic pricing decision-making according to their awareness of Islamic values as a form of justice, namely fairness in pricing based on market segments and based on product value-added. This research will provide knowledge to business people to consider ethics in the strategic policy of price management conducted.</em></p>
Combining Variable Neighbourhood with Gradient Ascent for Learning to Rank Problem
Authors: Ibrahim Osman Ali Sadek , Younis Eman M. G. 
Published: December 2022

Abstract
Variable Neighbourhood Search (VNS) is used to optimize the solutions for heuristic problems. Solutions are based on neighboring solution systematic changes. The changes are made during the ascending phase to get local optimum and the perturbation phase to gain the global optimum solutions. Exploration and Exploitation procedures are made through various mutation step-size. The objective function to choose the best offspring to be move to the next evolving generation. Thus, this paper uses a variation of VNS based on four random probability distributions with Gradient Ascent for adapting the mutation of Neighborhood solution in the next iteration. It has the ability moderate the next proposed neighbourhood based of the Parent and Offspring fitness values. We called this novel approach in Learning to Rank (LTR) as Gradient Variable Neighbourhood (GVN). This variant generates each Offspring ranking model solution from one probability distribution in the whole mutation procedure (all mutation step-sizes made by only one probability distribution for each Neighbourhood candidate). From the obtained results, we can conclude that the GVN method outperformed the recent research of Evolutionary and Machine Learning methods. In the experiments, we used Yahoo, Microsoft Bing Search (MSLR-WEB10K) and LETOR 4 (MQ2008, MQ2007) datasets.