bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for atlantoaxial dislocation in rheumatoid arthritis: A comparative study
Authors: Ben Tekaya Aicha , Rezgui Soumaya , Tbini Houssem , Bellil Mehdi , Bouden Selma , Rouached Leila , Tekaya Rawdha , Mahmoud Ines , Saidane Olfa , Abdelmoula Leila 
Published: October 2022

AbstractBackgroundThe objective of the study was to assess clinical and imaging features of rheumatoid arthritis associated with atlantoaxial dislocation (RA‐AAD) in comparison to RA without AAD (RA‐C) and to identify the associated factors to AAD.MethodsThis was a retrospective comparative study including RA patients over 18 years old. The control group of RA‐C was matched according to age (±2 years), gender, and RA duration (±2 years). General data, RA characteristics, AAD features, and treatment modalities were recorded. Statistical analysis was performed to determine the predictive factors of AAD.ResultsA total of 120 patients were included (78 RA‐AAD and 42 RA‐C); sex‐ratio was 0.15. Mean age was 58.55 ± 9.14 years (RA‐AAD) versus 60.43 ± 10.78 years (RA‐C), (p = 0.31). Regarding RA features, RA‐AAD patients have significantly a higher rheumatoid factor (RF) rate (p = 0.002), extra‐articular manifestations (p = 0.009) especially osteoporosis (p < 10−3), eye involvement (p = 0.02), coxitis (p < 0.0001), Disease Activity Score (DAS28) (p < 10−3), and global health status scale (HAQ) (p = 0.003).X‐ray analysis showed pathologic PADI (<14 mm) in 51.6% of cases. The AADI was pathological (>3 mm) in 100% of patients with the following distribution: 67.9% between (3–6 mm) and 23.3% between (6–9 mm). Atlantoaxial dislocation (AAD) was presumed anterior (85.4%), lateral (7.3%) and rotatory (7.3%). The abnormalities observed on magnetic resonance imaging (MRI) were: C1–C2 synovitis (61%), confirmed AAD (34.1%) and basilar impression (4.9%). AAD diagnosed by cervical MRI was anterior in 89.8% of cases, lateral (5.3%) and with a double ascending and anterior component in 4.9% of cases. An immobilisation with a type C4 cervical collar was indicated for all the patients and five of them had boluses of corticosteroid (methylprednisolone 1 g/day) for three consecutive days. C1–C2 arthrodesis by trans‐articular screwing was performed in four patients with neurological signs or pathological measurements on cervical MRI. The outcome was favourable in 100% of cases after surgical treatment with improvement in neck pain and neurological condition within a mean decline of 4 ± 3 years [1–7].Multivariate analysis identified coxitis, osteoporosis, high baseline DAS28, and a high rate of RF positivity as predictive factors of AAD.ConclusionOur results confirmed that predictive factors of AAD were related to higher disease activity and structural damage. These modifiable factors may be prevented by tight control, early treatment, and educating RA patients to improve treatment adherence.
Simplified method for evaluating the response of existing tunnel induced by adjacent excavation
Authors: Feng Guohui , Xu Changjie , Liang Luju , Tey Ming‐wang , Chi Min‐liang , Ge Shangqi 
Published: October 2022

AbstractAdjacent excavation may have a negative influence on the existing tunnel underneath. Thus, it is important to evaluate the response of the tunnel due to adjacent excavation. However, there is little report about using the Kerr foundation model to simulate the tunnel‐soil interaction. Meanwhile, the Timoshenko beam, which can take the tunnel shearing effect into consideration, is more suitable to estimate the behavior of the tunnel. To simulate the interaction between soil and tunnel, the existing tunnel is simplified as a Timoshenko beam lying on the Kerr foundation model, and a simplified theoretical method is proposed to calculate the response of the existing tunnel induced by adjacent excavation. The proposed method is validated by two field case studies. Results indicate that the predictions given by the proposed method show great agreement with field measurements and it is more accurate to evaluate the tunnel‐soil interaction compared with the previous method. The further parametric study shows that the relative position between excavation and tunnel, the ground Young's modulus, the depth of existing tunnel centerline, and length and width of excavation are both significant factors governing the tunnel response induced by adjacent excavation, while the influence of tunnel shear stiffness and skew between tunnel and excavation are slight. The proposed method can be applied to predict the potential risk of existing tunnels induced by adjacent excavation in relevant engineering projects.
Dielectric response and density functional theory assessment of fluorinated dicationic pyridinium ionic liquids
Authors: Abdel‐Basset Trob A. , Rezki Nadjet , Al‐Sodies Salsabeel A. , Aouad Mohamed Reda , Bashal Ali H , Sharfalddin Abeer A. , Jaremko Mariusz , Emwas Abdul‐Hamid , Hagar Mohamed 
Published: October 2022

AbstractThis study represent the synthesis and electrical conductivity of two focused dicationic pyridinium ionic liquids (DiILs) carrying tetrafluoroborate and/or hexafluorophosphate as counter anion. Thus, the synthesis required quaternization of the pyridine nitrogen atoms first, followed by a metathetical exchange reaction to produce the task‐specific ILs bearing tetrafluoroborate and hexafluorophosphate as counter anions. The resulting DiILs were characterized by NMR and MS spectroscopy. The dielectric constant and the conductivity of the targeted DiILs were analyzed in detail, within a frequency‐range of 1 KHz to 0.3 MHz and a temperature range of 25–100°C. Density functional theoretical (DFT) calculations were also carried out at the base site, B3LYP 6–311 g (d,p), for the Syn/E isomers of the investigated ionic liquids (ILs). We found non‐coplanar molecular geometries with a twist angle of the Schiff base, dependent on the type of counter ion present. The energy levels and differences of the frontier molecular orbitals (FMOs) were also predicted using DFT calculations. The results revealed that the ILs incorporating BF4− as counter anions showed high HOMO and LUMO values with a higher energy gap, while low FMOs with a lower energy gap were recorded for the derivative encompassing PF6− counter anions. These findings were used to help explain the dielectric properties of the investigated DiILs.
Developing the “Healthcare CEO App” for patients with type 1 diabetes transitioning from adolescence to young adulthood: A mixed‐methods study
Authors: Chiang Yueh‐Tao , Chang Chi‐Wen , Yu Hsing‐Yi , Tsay Pei‐Kwei , Lo Fu‐Sung , Chen Chi‐Wen , Lin Wen‐Yen , Hsu Chien‐Lung , An Chi , Moons Philip 
Published: October 2022

AbstractAimTo develop and test a mobile application that supports the disease self‐management of adolescents with type 1 diabetes during their transition to early adulthood.DesignA sequential mixed‐methods design was employed.MethodsThe application content was designed according to previously identified care needs and expectations, followed by application development on the Android operating system. From the outpatient clinic of the Department of Paediatric Endocrinology and Metabolism at a medical centre in northern Taiwan, 35 individuals aged between 16–25 years participated in application testing.ResultsThe overall median score of the QUIS was 4–5, most of the 25% quartile was 4–5, and all of the 75% quartile was 5, indicating adequate user interaction satisfaction.
Ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight tandem mass spectrometry coupled with three‐step data post‐processing techniques for comprehensive profiling of the multiple components in Fufang Xianzhuli Ye
Authors: Wang Lanxin , Fu Huizheng , Li Junmao , Chen Linan , Yang Jiaxi , Zhong Lan , Xiao Xiaowu , Feng Yulin , Luo Yuehua 
Published: October 2022

AbstractIntroductionFufang Xianzhuli (FXZL) Ye, a classical formula of traditional Chinese medicine, is composed of Succus Bambusae, Houttuyniae herba, Pinelliae Rhizoma, Zingiberis Rhizoma Recens, Eriobotryae Folium, Platycodonis Radix, and peppermint oil. For many years, FXZL has been primarily utilised in China to treat cough and phlegm. The chemical composition of FXZL has not been reported, which seriously affects the safety of the clinical application.ObjectiveTo establish a systematic method for rapidly classifying and recognising the chemical constituents in the FXZL for the safety of the clinical application.MethodsAn ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry coupled with a three‐step data post‐processing strategy was developed to screen the chemical constituents of FXZL.ResultsIn this experiment, the diagnostic ions in FXZL were classified into six main compounds. A total of 106 compounds were unambiguously identified in FXZL based on their retention times, accurate masses, and tandem mass spectrometry data. These include 11 chlorogenic acids, three flavonoids, eight sesquiterpenoids, six organic acids, 65 triterpenoid saponins, and 13 other compounds.ConclusionThe chemical composition of FXZL was identified and summarised, providing useful information for quality control and a basis for further exploration of its active ingredients in vivo.
Trends and regional variations in prescriptions dispensed to stimulate uterine contractions at the end of pregnancy in Belgium: A community‐based study from 2003 to 2018
Authors: Larcin Lionel , Karakaya Güngör , Rygaert Xavier , Van Wilder Philippe , Lamy Clotilde , Demyttenaere Bart , Damase‐Michel Christine , Kirakoya‐Samadoulougou Fati 
Published: October 2022

AbstractPurposeTo investigate trends and regional variations in uterotonics dispensed around birth between 2003 and 2018 in Belgium.MethodsData, including outpatient and inpatient prescriptions were extracted from a nationally representative prescription database. The prevalence of uterotonics dispensed during a period including the 7 days before birth, the delivery day and the 7 days after birth was computed over three 4‐year‐long study periods from 2003 to 2018. The trends between periods and associations between the use of at least one uterotonic and maternal age, region of residence, delivery type and social status were assessed using logistic regression.ResultsIn total, 31 675 pregnancies were included in the study. The proportion of pregnancies exposed to at least one uterotonic decreased significantly from 92.9% (95%CI, 92.3–93.4) in 2003–2006 to 91.4% (95%CI, 90.7–92.0) in 2015–2018 for vaginal births and from 95.5% (95%CI, 94.5–96.4) to 93.7% (95%CI, 92.6–94.7) for caesarean sections. However, for vaginal births, the proportion of oxytocin increased from 84.5% (95%CI, 83.7–85.2) to 89% (95%CI 88.3–89.7). A significant association was found between uterotonic agent use and maternal age, region of residence, and delivery type. The dispensation of some uterotonic agents differed significantly between the regions.ConclusionsThe proportion of pregnancies exposed to at least one uterotonic was high across the study period but decreased slightly between 2003 and 2018. Important variations in uterotonic use between regions highlight the need for improved national guidance.
Do fake online comments pose a threat to regulatory policymaking? Evidence from Internet regulation in the United States
Authors: Handan‐Nader Cassandra 
Published: October 2022

AbstractBroad stakeholder participation in regulatory policymaking via online commenting platforms has become the norm in many advanced democracies around the world. In recent years, a policy debate has emerged over the dangers posed to the process by fake comments that impersonate ordinary citizens. This paper helps to clarify the terms of this debate by evaluating a contentious and prominent case in the United States, the nearly 24 million comments from the Federal Communications Commission's 2017 Restoring Internet Freedom proceeding. Using a two‐step methodology that combines a computationally efficient search algorithm and a neural network language model, I show that regulators were able to cite much of the relevant information submitted in public comments by relying on longstanding methods of information gathering through interest groups, despite the fact that fake comments outnumbered others 3 to 1. The results suggest that fake comments did not impede regulators' ability to extract specialized information from the public consultation process, but may have distorted signals from mass comment campaigns about constituent mobilization.
The clinical decision‐making process of healthcare professionals within a personalized home‐based rehabilitation program during sequential chemoradiotherapy for stage III non‐small lung cancer: A case study
Authors: Voorn Melissa J. J. , Schröder Carin D. , Boogaart Vivian E. M. van Kampen‐van den , Willems Wendy , Bongers Bart C. , Janssen‐Heijnen Maryska L. G. 
Published: October 2022

AbstractIntroductionThe purpose of this case study was to demonstrate the clinical decision‐making process of healthcare professionals within a rehabilitation program during chemoradiotherapy (CHRT) for a high‐risk patient diagnosed with stage III non‐small cell lung cancer (NSCLC). The course of CHRT and patient's preferences, facilitators, and barriers were considered.Case‐descriptionThe patient was a 69‐year‐old man with a history of rheumatoid arthritis diagnosed with stage III NSCLC.InterventionA home‐based, personalized, and partly supervised rehabilitation program during CHRT, including aerobic, resistance, and breathing exercises, as well as nutritional counseling.OutcomesThe patient suffered from side effects of CHRT, which required adjustments in the context and intensity of the exercises. An important facilitator for the patient was encouraged by his wife in following the home‐based rehabilitation program. During home visits, the patient and physiotherapists performed the exercises together to help him to overcome the burden and motivate the patient to adhere to the rehabilitation program.ConclusionThis case study demonstrates that physical exercise training could be performed by adjusting training intensity and the way in which the physical exercise training was delivered, while the patient experienced side effects from CHRT. In addition, the involvement and support of (in)formal caregivers seems essential for adherence to rehabilitation.
Temporary stenting in a case of bronchomalacia due to relapsing polychondritis
Authors: Handa Hiroshi , Tsuruoka Hajime , Matsuzawa Shin , Azagami Shinya , Mineshita Masamichi 
Published: October 2022

AbstractAirway involvement in relapsing polychondritis (RP) can often be debilitating and life threatening. Interventional procedures such as stenting can be useful to improve airway stenosis. This case was diagnosed with RP with a circumferential obstruction at the left main bronchus. We determined that a silicone airway stent would be placed. The silicone stent was removed after 22 months due to granulation tissue. After stent removal, bronchoscopic findings revealed a collapsing left main bronchus during exhalation, but airway patency was maintained during inhalation without any respiratory symptoms. In this case, bronchomalacia remained after stent removal. However, since there were no severe respiratory symptoms, we decided that stent replacement was unnecessary. In general, it is difficult to remove airway stents in severe tracheobronchomalacia; however, temporary stenting might be a useful procedure in cases with unilateral main bronchial stenosis.
Adaptive variable impedance position/force tracking control of fracture reduction robot
Authors: Zheng Gongliang , Lei Jingtao , Hu Lei , Zhang Lihai 
Published: October 2022

AbstractBackgroundThe operation object of robot‐assisted fracture reduction surgery is the musculoskeletal tissue with rigid‐compliance coupling characteristics. It is necessary to improve the interactive compliance and safety between the reduction robot and the musculoskeletal tissue.MethodAn adaptive variable impedance position/force tracking control strategy based on friction compensation is proposed. The stiffness of the reduction robot can be adaptively adjusted according to the contact force between the end‐effector and the environment. The Stribeck friction force model of the branch chain electric cylinder is derived to improve the motion control performance.ResultsThe fracture reduction experiment is completed. The experimental results show that the adaptive variable impedance position/force control strategy can realize position and force tracking in fracture reduction.ConclusionA safety control strategy is proposed and applied to robot‐assisted fracture reduction surgery, which improves the coordination and compliance of the human‐robot interaction between the reduction robot and the patient.
Design and validation of looping assistance methods in robotic‐assisted neonatal surgical suturing in a chest model
Authors: Marques Marinho Murilo , Oikawa Risa , Hayashi Kentaro , Takazawa Shinya , Harada Kanako , Mitsuishi Mamoru 
Published: October 2022

AbstractBackgroundNeonate patients have a reduced thoracic cavity, making thoracoscopic procedures even more challenging than their adult counterparts.MethodsWe evaluated five control strategies for robot‐assisted thoracoscopic surgical looping in simulations and experiments with a physical robotic system in a neonate surgical phantom. The strategies are composed of state‐of‐the‐art constrained optimization and a novel looping force feedback term.ResultsAll control strategies allowed users to successfully perform looping. A user study in simulation showed that the proposed strategy was superior in terms of Physical demand and task duration . The cumulative sum analysis of inexperienced users shows that the proposed looping force feedback can speed up the learning. Results with surgeons did not show a significant difference among control strategies.ConclusionsAssistive strategies in looping show promise and further work is needed to extend these benefits to other subtasks in robot‐aided surgical suturing.
Factors associated with lesion detection in colonoscopy among different indications
Authors: Mangas‐Sanjuan Carolina , Seoane Agustin , Alvarez‐Gonzalez Marco Antonio , Luè Alberto , Suárez Adolfo , Álvarez‐García Verónica , Bujanda Luis , Portillo Isabel , González Natalia , Cid‐Gomez Lucía , Cubiella Joaquín , Rodríguez‐Camacho Elena , Ponce Marta , Díez‐Redondo Pilar , Herráiz Maite , Pellisé María , Ono Akiko , Baile‐Maxía S. , Medina‐Prado L. , O Murcia , Zapater Pedro , Jover Rodrigo ,   QUALISCOPIA Study Investigators
Published: October 2022

AbstractBackground and objectiveDifferent factors may influence colonoscopy performance measures. We aimed to analyze procedure‐ and endoscopist‐related factors associated with detection of colorectal lesions and whether these factors have a similar influence in the context of different colonoscopy indications: positive fecal immunochemical test (+FIT) and post‐polypectomy surveillance colonoscopies.MethodsThis multicenter cross‐sectional study included adults aged 40–80 years. Endoscopists (N = 96) who had performed ≥50 examinations were assessed for physician‐related factors. Adenoma detection rate (ADR), adenomas per colonoscopy rate (APCR), advanced ADR, serrated polyp detection (SDR), and serrated polyps per colonoscopy rate (SPPCR) were calculated.ResultsWe included 12,932 procedures, with 4810 carried out after a positive FIT and 1967 for surveillance. Of the 96 endoscopists evaluated, 43.8% were women, and the mean age was 41.9 years. The ADR, advanced ADR, and SDR were 39.7%, 17.7%, and 12.8%, respectively. Adenoma detection rate was higher in colonoscopies after a +FIT (50.3%) with a more than doubled advanced ADR compared to non‐FIT procedures (27.6% vs. 13.0%) and similar results in serrated lesions (14.7% vs. 13.5%). Among all the detection indicators analyzed, withdrawal time was the only factor independently related to improvement (p < 0.001). Regarding FIT‐positive and surveillance procedures, for both indications, withdrawal time was also the only factor associated with a higher detection of adenomas and serrated polyps (p < 0.001). Endoscopist‐related factors (i.e., weekly hours dedicated to endoscopy, annual colonoscopy volume and lifetime number of colonoscopies performed) had also impact on lesion detection (APCR, advanced ADR and SPPCR).ConclusionsWithdrawal time was the factor most commonly associated with improved detection of colonic lesions globally and in endoscopies for + FIT and post‐polypectomy surveillance. Physician‐related factors may help to address strategies to support training and service provision. Our results can be used for establishing future benchmarking and quality improvement in different colonoscopy indications.
Medical management of primary tracheal collapse in a cat
Authors: Viñeta Clàudia , López María Cristina , Verdés Judit , Roura Xavier 
Published: October 2022

AbstractA 2‐year‐old, neutered, female domestic shorthair cat was referred with 3‐day history of coughing and respiratory distress. At presentation, the cat had severe inspiratory dyspnoea. Thoracic radiographs, computed tomography, tracheobronchoscopy and bronchoalveolar lavage were performed. A grade II primary cervical tracheal collapse was diagnosed. The cat was discharged with co‐amoxiclav (at 22 mg/kg orally every 12 hours for 15 days) and methylprednisolone (at 1 mg/kg orally every 24 hours), with the dose being gradually decreased over a period of 2 months. The clinical signs improved progressively, and 12 months later, no clinical signs were evident. To the authors’ knowledge, this is the first description of a feline primary tracheal collapse treated without surgical intervention with an excellent clinical response.
Gravimetry by Nanoscale Parametric Amplifiers Driven by Radiation-Induced Dispersion Force Modulation
Authors: Pinto Fabrizio 
Published: October 2022

Abstract
Here we present early results from lumped-element numerical simulations of a novel class of nano electromechanical systems (NEMS) presently being considered for ground-based gravimetry and future micro accelerometry applications in GPS-denied environments, including spacecraft. The strategy we discuss is based on measuring the effects of non-inertial or gravitational forces on the dynamics of a standard oscillator driven at its resonance frequency by a time-dependent electrostatic potential. In order to substantially enhance the sensitivity of the instrument, the oscillating mass is made to simultaneously interact with a nearby boundary so as to be affected by quantum electrodynamical Casimir forces. Furthermore, unlike previously published proposals, in the design presented herein the Casimir boundary does not oscillate but it is a fixed semiconducting layer. As already demonstrated experimentally, this arrangement enables Casimir force time-modulation by semiconductor back-illumination. Such a design strategy, first suggested by this author as a promising approach to gravitational wave detection in different nano-sensors, allows for the realization of a Casimir force-pumped mechanical parametric amplifier. Such devices can, in principle, yield gains of several orders of magnitude in the mechanical response amplitude over the response from standard unpumped oscillators. The numerical proof-of-concept first presented herein points to a potentially new class of gravimetry products based on exploiting appropriately engineered dispersion forces as an emerging enabling general purpose technology on the nanoscale.