bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limiting calcium overload after cardiac arrest: The role of human albumin in controlled automated reperfusion of the whole body
Authors: Pooth Jan-Steffen , Brixius Sam J , Scherer Christian , Diel Patric , Liu Yechi , Taunyane Itumeleng C , Damjanovic Domagoj , Wolkewitz Martin , Haberstroh Jörg , Benk Christoph , Trummer Georg , Beyersdorf Friedhelm 
Published: March 2022

Background Regarding the overall inadequate results after cardiopulmonary resuscitation, the development of new treatment concepts is urgently needed. Controlled Automated Reperfusion of the whoLe body (CARL) represents a therapy bundle to control the conditions of reperfusion and the composition of the reperfusate after cardiac arrest (CA). The aim of this study was to investigate the plasma expander’s role in the CARL priming solution and examine its mechanism of action. Methods Viscosity, osmolality, colloid osmotic pressure (COP), pH and calcium binding of different priming solutions were measured in vitro and compared to in vivo data. N = 16 pigs were allocated to receive CARL following 20 min of untreated CA with either human albumin 20% (HA, N = 8) or gelatin polysuccinate 4% (GP, N = 8). Blood gas analyses were performed during the first hour of reperfusion and catecholamine and fluid requirements were recorded. Neurological outcome was assessed by neurological deficit scoring (NDS) on the seventh day. Results In vitro, addition of HA to the CARL priming solution resulted in higher COP and higher calcium-binding than GP. In vivo, treatment with HA led to greater reduction of ionized calcium and higher extracorporeal flows within the first 30 min of reperfusion with no difference in catecholamine support and fluid requirement. Seven-day survival of 75% with no difference in NDS was observed in both groups. Conclusions Our data show that the plasma expander in the CARL priming solution has a significant effect on the initial reperfusate and can potentially influence the course of resuscitation. However, seven-day survival and NDS did not differ between groups.
Surgical dilemma – spare or replace regurgitant aortic valve: Late comparative outcomes of two strategies
Authors: Karciauskas Dainius , Zieniute Viktorija , Jakuska Povilas , Ereminiene Egle , Kinduris Sarunas , Nedzelskiene Irena , Dirsiene Ruta , Bieseviciene Monika , Benetis Rimantas 
Published: March 2022

Background To evaluate different aortic root surgery techniques and their contemporary clinical outcomes in patients with regurgitant aortic valve and aortic root aneurysm. Methods The study consisted of 141 adult patients who underwent aortic valve reimplantation (David group = 73) or aortic valve replacement surgery (Bentall group = 68) for aortic valve regurgitation (AR) and dilatation of the aortic root at our institution within the same period (April 2004–October 2016). Kaplan–Meier method was used to estimate survival and other clinically relevant outcomes between the groups. Results The completeness of clinical follow-up was 100%, with a mean time of 8.0 ± 3.8 years. Thirty-day (in-hospital) mortality rates were equivalent between groups (1.3 and 1.5%, p = 1.0). The overall survival rates at 10 years were significantly better for the David group patients comparing to Bentall group patients (95.3 ± 2.6% vs 79.7 ± 6.8%; p = 0.04) with similar freedom from AV related reoperation (94.4 ± 2.7% vs 98.5 ± 1.5%; p = 0.2). Freedom from bleeding events at 10 years was 90.7 ± 3.6% for Bentall group patients and none were observed among David group patients ( p = 0.01). Conclusions Aortic valve and root surgery can be performed with equivalent safety and efficacy using either valve-sparing (David procedure) or valve-replacing (Bentall procedure) techniques in selected patients. Furthermore, patients after the David procedure demonstrated significantly improved survival and low risk of bleeding in comparison to the Bentall procedure with an acceptable risk of reoperation at 10 years follow-up.
Factors Associated With Impeding the Reintegration of Incest Survivors: A Qualitative Study in Selected Safe Homes in Nepal
Authors: Khatiwada Januka , Isono Maho , Ogawa Toshio 
Published: March 2022

Background Incest is a globally prevalent phenomenon and is defined as sexual relations between closely related family members. Despite being a criminal offense irrespective to the gender and age incest is a prevalent issue in Nepal. Incest survivors are sheltered in safe homes for specific periods and reintegrated into their families following their healing. This research aims to explore the challenges and issues involved in the reintegration of incest survivors and investigate how the interconnected perceptions of families and individuals relate to the incest survivors’ successful reintegration. Methods This qualitative study was conducted in three districts of Nepal. Fourteen incest survivors, five service providers from safe homes, and 22 community members were purposefully and theoretically selected. Semi-structured interviews were carried out to collect the study data, which were subsequently coded and analyzed using a grounded theory approach. Results The results indicate the importance of the reintegration of incest survivors, as staying in a safe home may not offer a long-term solution for these individuals. However, reintegration is challenging without acceptance and support from the survivors’ families and communities, the survivors' readiness to reintegrate, and agreement from the survivors’ safe homes. Factors found to influence the unsuccessful reintegration of survivors included family fragmentation, socio-economic status, family resistance, the survivor-perpetrator relationship, survivors’ interests, fears, and the possibility of repeated incidents, harmful social norms and cultural practices, community intervention, and negative perceptions. Conclusion This study found that factors associated with impeding the reintegration of incest survivors are found in survivors, their families, and their communities. Creating harmonious family systems, providing education on gender equality, empowering women to fight against all sorts of abuse, and governmental assurances on the implementation of legal aid, human rights, ratified conventions on child rights and women’s rights may help prevention of incest, and address the reintegration challenges of incest victims.
“It’s Okay With Our Culture but We’re in a Different Place and We Have to Show Respect”: Marshallese Migrants and Exclusive Breastfeeding Initiation
Authors: Ayers Britni L. , Purvis Rachel S. , Bogulski Cari A. , Reece Sharon , CarlLee Sheena , Kim Yeary Karen H. , McElfish Pearl A. 
Published: March 2022

Background: Pacific Islanders in the United States have lower initiation rates and shorter duration of exclusive breastfeeding compared to other racial/ethnic groups. Research Aim: To describe infant feeding beliefs and experiences of Marshallese living in the United States. Methods: We used a prospective and cross-sectional exploratory, descriptive qualitative design with Marshallese participants ( N = 36) residing in the United States between July 2019 and July 2020. Data were collected at 6–8 weeks postpartum. Our qualitative analytic approach integrated inductive and deductive techniques. Results: Participants’ mean age was 27.1 years ( SD = 6.1), and 88.9% ( n = 32) were born in the Marshall Islands. A majority of participants were single, widowed, or in an unmarried partnership ( n = 28, 77.8%). Most participants had a high school education or lower ( n = 30, 83.3%). Mean household size was 7.2 ( SD = 2.8). Fewer than half of participants had no health insurance ( n = 14, 38.9%), and almost all participants (91.7%) did not work at the time of data collection. Two themes emerged: 1) infant feeding initiation and practices; and 2) concerns over breastfeeding in public. The majority of participants’ infants received both human milk and formula. Participants described beliefs that breastfeeding in public was against American customs, which influenced their decision about breastfeeding in public. Conclusions: Our study was the first to document infant feeding beliefs and experiences of Marshallese living in the United States at 6–8 weeks postpartum. Findings will inform future health education programs.
Study of matrix modifications by nano-clay on the mechanical properties of AA3003 honeycomb sandwich panels
Authors: Prasanth P.V. , Sahaya Raj M.Edwin , Jappes J.T.Winowlin , Jayaram R.S. 
Published: March 2022

Face/core debonding is one of the crucial problems of composite sandwich panels which consist of AA3003 aluminium honeycomb and glass fiber reinforced polymer face sheets. The panel was prepared by a hand-lay process at different nano-clay weight addition of 0%, 2%, 4%, and 6% with the objective of improving face/core adhesion. Interface bonding between face sheets and honeycomb core composite sandwiches and their mechanical behavior were investigated under in-plane compression and bending load. The flexural property of sandwich panels due to the influence of variation in strain rate is further determined. The morphologies of fractured samples were investigated by scanning electron microscope (SEM). The results revealed a significant improvement in mechanical characteristics when nano-clay was loaded to the composites at a concentration from 2 to 4 wt%, and the in-plane compression and flexural failure load values increased by 45% and 81%, respectively, when compared to a pristine sample. It was observed that increasing strain rate led to the increase in failure load of the sandwich panel. SEM images of fractured surfaces showed residual aluminium honeycomb was present in the face sheet, which indicates better adhesion between aluminium honeycomb core and face sheets.
Organizing pneumonia as a possible pulmonary manifestation of systemic lupus erythematosus: Three cases and a review of literature
Authors: Ito Yuhei , Tamada Tatsuya , Okunishi Yuki , Mizutani Satoshi , Yamamoto Yoshiki , Nakajima Ayako 
Published: March 2022

Background: Organizing pneumonia (OP) is a rare manifestation of systemic lupus erythematosus (SLE). It has been described in very few case reports. Purpose and Methods: We encountered OP in three patients with SLE in 1 year; two manifested OP as an initial presentation of SLE, while the third manifested OP when SLE relapsed. To elucidate the clinical features and outcomes of OP in patients with SLE, we screened the PubMed database for cases diagnosed with OP either at or after the diagnosis of SLE; the search was restricted to articles that were published after 1990, when OP became widely recognized. Results: We identified 15 cases of OP in patients with SLE. Thus, we analyzed a total of 18 cases (including our three). OP developed at the initial diagnosis of SLE in 15 cases and at relapse of SLE in three cases. In most cases, the disease activity of SLE was moderate or high. In all cases, OP was accompanied by other extrapulmonary symptoms of SLE, namely, fever (77.8%), cutaneous manifestations (61.1%), arthralgia/arthritis (50%), and lupus nephritis (33.3%). Steroid monotherapy or increasing the dose of the steroids was effective in seven cases (38.8%); however, steroid monotherapy was ineffective and led to death due to respiratory failure in two cases (11.1%). Combination therapies of steroids with hydroxychloroquine, azathioprine, tacrolimus, mycophenolate mofetil, intravenous pulse cyclophosphamide therapy, and belimumab were effective in seven cases (38.8%). Conclusions: Based on the review of previously reported and our cases, we concluded that OP is an important pulmonary manifestation of SLE. Clinicians should be aware of it as it may require intensive immunosuppressive therapy either at or after the diagnosis of SLE.
Posterior reversible encephalopathy syndrome in juvenile lupus- a case series and literature review
Authors: Baisya Ritasman , Kumar Devarasetti Phani , Narayanan Ramakrishna , Rajasekhar Liza 
Published: March 2022

Introduction: PRES, as a complication of juvenile lupus, is rarely reported in the literature. In this study, six juvenile lupus patients admitted with diagnosis of PRES were assessed on the basis of clinical characteristics, imaging findings, disease activity status, treatment response and prognosis. Methodology: Six juvenile (≤ 16 years) lupus patients with a diagnosis of PRES were included. Demographic, clinical, and laboratory features and outcomes of all six patients were noted. Literature review was performed on PubMed search forum. Search terms in English included Juvenile SLE, Lupus and PRES. Result: The youngest patient was seven years old while the oldest was sixteen years. All patients had history of lupus nephritis , presented with seizure and hypertension. In imaging, four out of six patients had hyperintensities in atypical distribution suggesting atypical PRES. All the patients had significant clinical recovery with resolution of hyperintensities in five out of six patients on repeat imaging. Conclusion: Juvenile lupus with PRES is considered an unusual neurologic manifestation triggered by multiple factors. It can be stipulated that PRES in juvenile lupus cases often remain undiagnosed. Early suspicion and treatment institution with reversal of triggers can result in a favorable outcome in these patients.
Cultural Influences on Hispanic Mother–Daughter Communication About Sex
Authors: Matsuda Yui , DeBastiani Summer D. , Thalasinos Roxana D. , Ferranti Dina , Norris Anne E. , De Santis Joseph P. 
Published: March 2022

Introduction: Hispanic adolescents are at high risk of engaging in sexual risk-taking behaviors. Parent–child communication protects against such behaviors. Among Hispanic families, it is critical to explore how cultural characteristics influence mothers–daughter communication about sex. The purpose of this qualitative study was to understand how cultural values influence mothers’ communication about sex with their early adolescent Hispanic daughters. Methodology: Twenty-one Hispanic mothers of seventh-grade daughters participated in this focus group study. Directed content analysis was used to analyze the data. Results: Four Hispanic cultural values ( familismo, machismo, marianismo, and respeto) and how each value influences mother–daughter communication about sex were identified. While mothers want to protect their daughters, there are multiple cultural norms that made it challenging for them to have critical conversations. Discussion: The study informs researchers and clinicians how to facilitate parent–child conversations about sex and to equip parents to teach their children how to avoid engaging in sexual risk-taking behaviors.
A Mixed-Methods Evaluation of the Feasibility of a Medical Management-Based Text Messaging Intervention Combined With Buprenorphine in Primary Care
Authors: Tofighi Babak , Durr Meghan , Marini Christina , Lewis Crystal F , Lee Joshua D 
Published: March 2022

Background: Mobile health (mHealth) tools offer an effective and personalized approach to enhance chronic disease management and may partially offset provider-level barriers to increasing buprenorphine prescribing in primary care. This study assessed the feasibility of integrating a text messaging-based medical management tool (TeMeS) in primary care among patients initiating buprenorphine. Methods: TeMeS messages are categorized per the medical management model, programed in a HIPAA-compliant texting software (Apptoto©), and delivered in a tiered fashion over 8-weeks to patients. This mixed-methods evaluation of TeMeS utilized key stakeholder feedback (patients, physicians, administrators, nursing), text messaging software process measures, thematic analysis of patient participant text message content, and electronic administrative data (eg, appointment adherence, treatment retention) at 2-months. Results: The study team approached 65 patients and n = 14 (21%) were ineligible or declined to participate in the study. Most eligible participants owned a smartphone (90%), responded to at least one text query (88%) over an average of 24 days, and few requested to stop receiving texts (6%). Participant text replies included responses to cognitive behavioral therapy-based queries (13.8%), confirming or rescheduling appointments (6.1%), and insurance, pharmacy, or clinical issues pertaining to buprenorphine dispensation or dosing (2%). Suggestions for design modifications included personalizing message content and adjusting message frequency per patient risk of illicit opioid reuse, use of video-based informational content, and real-time provider and staff support for emergent issues. Conclusion: Our findings highlight the acceptability, feasibility, and high rates of engagement of utilizing text messaging to enhance self-management among patients initiating buprenorphine treatment.
Prevalence of Soil-Transmitted Helminthes and Associated Risk Factors Among People of Ethiopia: A Systematic Review and Meta-Analysis
Authors: Aemiro Aleka , Menkir Sisay , Tegen Dires , Tola Gedam 
Published: March 2022

Background: A Soil-transmitted helminthic infection (STHIs) remains a notable health problem in resource-limited countries. Objective: This systematic review and meta-analysis aimed to determine the overall prevalence of STH infections in Ethiopia. Methods: Articles written in English were searched from online public databases. Searching terms taken separately and jointly were “prevalence,” “soil-transmitted helminths” “nematode,” “Geo-helminths,” “roundworm,” “Necator,” “Ancylostoma,” “Ascaris,” “Trichuris,” “hookworm,” “whipworm,” “ S. strecoralies,” “associated factors,” and “Ethiopia.” We used STATA version 14 for meta-analysis and Cochran’s Q test statistics and the I2 test for heterogeneity. Result: From 297 reviewed articles 41 fulfilled the inclusion criteria. The pooled prevalence of STH infections in Ethiopia was 36.78% Ascaris lumbricoides had the highest pooled prevalence 17.63%, followed by hook worm12.35%. Trichuris trichiura 7.24% when the prevalence of S. strecoralies was 2.16% (95% CI: 0.97-3.35). Age, sex, residence, family education level, lack of shoe wearing habits and open defecation were identified as risk factors for STH infection. Eating unwashed and uncooked fruit and vegetables increased the risk of STH infection by 1.88 times while untrimmed finger nail and lack of hand washing habits increase the risk of STH infection by 1.28 and 3.16 times respectively with 95% CI. Limitation: Lack of published studies from Afar, Gambela, Somali, and Benshangul gumuz regions may affect the true picture. The other limitation is that the search strategy will be restricted articles published only in the English language but there might be articles that published using another language. Conclusion: Ascaris lumbricoides, hookworms and Trichuris trichiura, are the most prevalent soil-transmitted helminthes infections in Ethiopia. Age, sex, residence, family education level, lack of shoe wearing habits Open defecation untrimmed finger nail and lack of hand washing habits significantly associated with STH infection. When eating unwashed, uncooked fruit and vegetables were not significantly associated with STH infection. Strategic use of anti-helminthic, health education, and adequate sanitation, taking into account this epidemiologic information is helpful in the control of STH infections in Ethiopia.
Parental experiences of home phototherapy for neonatal hyperbilirubinemia
Authors: Pettersson Miriam , Eriksson Mats , Blomberg Karin 
Published: March 2022

Newborns with hyperbilirubinemia have traditionally received phototherapy in hospital. Hospital stays for infants, however, may negatively affect parent–infant bonding and induce anxiety and feelings of powerlessness in mothers. This study examined parent’s experiences of providing phototherapy to their neonates at home instead. A descriptive qualitative study based on 15 interviews (8 mothers and 7 fathers) with parents of 8 children who had been randomised to home phototherapy was conducted during spring 2018 in Örebro county, Sweden. Inductive content analysis was used. The overall experience of home phototherapy was positive, and five categories were identified describing their experiences: continuing life at home, adjusting to having a newborn, feeling secure, experiencing parenthood and accessing information. The findings support the use of home phototherapy. Parents felt secure at home with their infants and emphasised the importance of clear information and round-the-clock access to hospital staff.
What will happen to my mom? A grounded theory on nurses’ support of relatives’ end-of-life decision-making process for residents living with dementia in long-term care homes
Authors: Daneau Stéphanie , Bourbonnais Anne , Legault Alain 
Published: March 2022

Background Relatives of an older person living in a long-term care home with advanced-stage dementia must often make important and difficult decisions, including ones that impact the resident’s end-of-life. Healthcare professionals must support them in this decision-making process. The aim of this study was to propose a theory on nurses’ support of relatives who make end-of-life decisions for a resident living with dementia in a long-term care home. Method A constructivist grounded theory approach was used, with a theoretical sample of nine nurses and 10 relatives whom we met for face-to-face interviews. Three documents on end-of-life care, which were available in the study setting, were also included. The analysis was carried out using the method proposed by Charmaz. Findings The findings highlight the importance of building a strong and trusting relationship between nurses and relatives. Furthermore, exploring the refusal of palliative or end-of-life care, supporting relatives’ need to witness firsthand the condition of the person living with dementia, and education at a “good” time are useful interventions that nurses can make to support relatives’ decision-making. Conclusion Better support of relatives in end-of-life decision-making improves the well-being of relatives and older people living with dementia alike.