bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering correlated insulators in bilayer graphene with a remote Coulomb superlattice
Authors: Wang Feng , Zhang Zuocheng , Xie Jingxu , Zhao Wenyu , Sanborn Collin , Wang Shaoxin , Kahn Salman , Watanabe Kenji , Taniguchi Takashi , Zettl Alex , Crommie Michael 
Published: November 2022

Abstract
Electron superlattices provide a powerful way to engineer novel correlated and topological quantum phenomena. Originally lithographic-patterned gate arrays were designed to create periodic superlattices in two-dimensional electron gases (2DEGs), where the superlattice potential can be continuously varied electrically. Fabricating superlattices at the nanometer scale with high precision, however, is challenging lithographically. Recently, moiré patterns in 2D materials have been found to offer near-perfect nanometer-scale electronic superlattices, which led to discoveries of exciting quantum phenomena in a variety of moiré heterostructures. However, the requirement of the moiré pattern poses a stringent limit on the material selection, and the moiré potential is not tunable for a given moiré heterostructure. To better engineer novel quantum phases, it will be desirable to create superlattices that combine the advantages of these two methods. Here we achieve this goal by engineering tunable correlated states in bilayer graphene with a remote Coulomb superlattice. The Coulomb superlattice is realized by localized electrons in a twisted bilayer WS2 that are 3 nm above the bilayer graphene. The period of the Coulomb superlattice is determined by the moiré period of the twisted bilayer WS2, and the strength of the superlattice potential is controlled by the number of localized electrons at the twisted bilayer WS2 moiré lattice site. We demonstrate that the 2DEG in encapsulated bilayer graphene is described by the Fermi liquid when the remote Coulomb superlattice is turned off. Electron correlation increases dramatically when the remote Coulomb superlattice is turned on, resulting in a series of correlated insulating states at both integer and fractional filling factors. This remote Coulomb superlattice can be applied to any 2D materials hosting a 2DEG. It opens a new route for in-situ control of correlated quantum phenomena in a wide variety of 2D systems.
Bevacizumab biosimilar candidate TAB008 compared to Avastin ® in patients with locally advanced, metastatic EGFR wild-type non-squamous non-small cell lung cancer: a randomized, double-blind, multicenter study
Authors: Lu S. , Qin S. , Zhou Z. , Chen J. , Gu K. , Sun P. , Pan Y. , Yu G. , Ma K. , Shi J. , Sun Y. , Yang L. , Chen P. , Liu A. , He J. 
Published: November 2022

Abstract
Background:
Bevacizumab(Avastin®) is a monoclonal antibody targeting the vascular endothelial growth factor (VEGF). Used alone or in combination with chemotherapy and/or immunotherapy, bevacizumab has shown promising efficacy in many cancers. This study compared the efficacy and safety of TAB008 with bevacizumab(Avastin®) sourced from the EU (bevacizumab-EU), in patients with non-squamous non–small cell lung cancer (nsNSCLC).
Method:
In this randomized, double-blind, multicenter, phase III similarity study, treatment naive, EGFR wild-type, locally advanced, metastatic, or recurrent non-squamous, non-small cell, lung cancer (ns-NSCLC) patients were enrolled and randomized (1:1) into TAB008 or Bevacizumab-EU groups. Patients received TAB008 or bevacizumab-EU 15 mg/kg intravenously plus paclitaxel/carboplatin for 4-6 cycles followed by TAB008 or bevacizumab-EU 7.5 mg/kg until disease progression, unacceptable toxicity or death. The primary endpoint compared the objective response rate (ORR) within 6 cycles as read by an independent radiological review committee (IRRC). Secondary endpoints compared disease control rate (DCR) Within 6 cycles, duration of response (DoR), progression free survival (PFS), a year overall survival rate (OSR), overall survival (OS), safety, immunogenicity, and steady state pharmacokinetics.
Results:
A total of 549 nsNSCLC patients were enrolled (277 in TAB008 group and 272 in Avastin® group). In the full analysis set, ORRs were 55.957% for TAB008 and 55.720% for Avastin®, the ORR ratio was 1 (90% CI 0.89-1.14), well within the predefined equivalence margin of 0.75 to 1.33. No significant differences were found in DCR within 6 cycles（95.703% vs 95.367%, p=0.8536）, DoR (8.17 vs 7.3 months, p=0.3526), PFS (9.10 vs. 7.97 months, p=0.9457), 1 year overall survival rate (66.2% vs 68%, p=0.6793), or OS (20.4 vs 17.6 months, p=0.6549). Serious adverse events (SAEs) occurred in 37.55% (104/277) of patients in the TAB008 group and 34.32% (93/271) in the Avastin® group. Anti-drug antibodies were reported in 3 of 277(1.08%) TAB008 patients, and 5 of 271(1.85%) Avastin® patients, neutralizing antibody (Nab) was positive in 1 patient on Avastin®, which became negative upon follow-up. The steady-state trough concentrations (Cssmin) were 106.13μg/mL in TAB008 group and 96.03μg/mL in Avastin® groups, with the treatment group ratio of LS geometric means fully contained within the bioequivalence limits of 80.00–125.00% (90% CI was 101.74%-120.05%).
Conclusions:
TAB008 is similar to bevacizumab-EU in terms of efficacy, safety, and pharmacokinetic parameters, with comparable immunogenicity.
ClinicalTrials.gov number, NCT05427305）
Combined effects of Vitamin D and neferine on the progression and metastasis of Colorectal cancer
Authors: Yang Jinfeng , Zhang Qinyu , Huang Guanlin , Cong Jiacheng , Wang Ting , Zhai Xiaoya , Zhang Juzheng , Qi Guangying , Zhou Lihua , Jin Jiamin 
Published: November 2022

Abstract
Purpose
To investigate the synergistic effect of Vitamin D and neferine on colorectal cancer (CRC) growth and metastasis.
Methods
First, the biologically active form of vitamin D, VD3 was conducted to investigate significant synergistic effect with neferine on CRC treatment by bliss analysis. Next, the colony formation and wound healing ability, the migration and invasion ability, the epithelial mesenchymal transition of HCT-116 cells under combination treatment of VD3 and neferine were assessed.
Results
VD3 and neferine showed synergistic effect on CRC cell growth both in a relatively low dose. The wound healing and colony formation ability, cell migration and invasion abilities were all decreased by combination use of VD3 and neferine, in comparing with VD3 or Neferine single treated group. Moreover, VD3 and Neferine significantly decreased N-cadherin, vimentin, Snail and Slug expressions in HCT-116 cells.
Conclusion
These data suggest that neferine enhances the anticancer capability of VD3 and reduces VD3 dose dependency. Combination of Vitamin D with neferine seems to be a potential therapeutic strategy for CRC.
Study of a warfare differential game via dynamic programming approach
Authors: BOUREMANI Touffik , SLIMANI Yacine 
Published: November 2022

Abstract
We use some recent developments in Dynamics Programming Method to obtain the complete and theoretically justified solution of a differential game formulated and studied in \cite{CHE} using the Lanchester equation. We use a certain refinement of Cauchy's Method of characteristics for stratified Hamilton-Jacobi equations to describe a large set of admissible trajectories and identify a domain on which the value function exists and is generated by a pair of admissible feedback strategies. Its optimality, is justified by using of one of the well-known verification theorems as an argument for sufficient optimality conditions.
MSC Classification: 49N70 , 49N35 , 49N90 , 91A23 , 49L20 , 34A60
Urban scaling of cities in Israel
Authors: Yatzkan Or Nissim , Omer Itzhak , Burg David 
Published: November 2022

Abstract
Cities have been shown to exhibit empirical scaling behavior where numerous variables of urban performance are allometric, like greenhouse gas emissions. Polluting emissions have negative environmental and health impacts. Therefore, recently, this methodology of urban scaling has been implemented to study the dynamics of vehicle and industrial emissions into the environment. It has been shown that cities may be environmentally efficient with CO2 emissions that seem to be sublinear, so the large cities may be more "green". However, a number of reports suggest a superlinear relationship with respect to population size, so the large cities may be less "green". We report here the results of the nonlinear allometric power-law scaling properties of multiple air pollutants in the Israel urban system, expanding the analysis to include electricity consumption and atmospheric emissions of CO2, NOx, SO2, CO, NMVOC, PM10, PM2.5, benzene and 1,3-butadiene. The results show the recurring mathematical patterns of cities similar to those reported elsewhere. Electricity usage is superlinear. Pollutant emissions of these greenhouse gases tend to exhibit significant superlinear dynamics (β > 1), though NMVOC and Benzene were linear. The superlinear result was conserved when regressing against the number of vehicles. This evidence supports the hypothesis that large cities may be less "green". Indeed, different urban characteristics such as geography, local climate and weather conditions, population density, may also affect the pollution levels of cities. Taken together these results give evidence to the effect of urban agglomerations on the environment. With this perspective it may be possible to implement sustainable policy to improve the environment and increase human wellbeing.
Tellurium-containing Thiol-peroxidase-like Antioxidants and their Catalytic
Mechanism
Authors: Capperucci Antonella , Tanini Damiano 
Published: November 2022

Abstract:
The development of novel small molecules with effective catalytic antioxidant properties is
highly sought after. A wide array of structurally diverse selenium- and tellurium-containing glutathione
peroxidase mimics have been studied over the past two decades. Within this arena, organotellurium
compounds generally exhibit higher catalytic properties with respect to selenium-containing analogues.
Different mechanisms accounting for the thiol-peroxidase-like activity of various classes of
organotellurium derivatives have been proposed. This review documents developments in this area
and provides an overview of the catalytic mechanisms proposed for the various classes of telluriumcontaining
thiol-peroxidase-like-catalysts.
Peningkatan Kesadaran Internet Sehat Menggunakan Blog Berbasis Internet of Things bagi Pemuda Desa Miru-Kabupaten Lamongan
Authors: Suharto Miko Aditiya , Apriyani Maria Novita , Safitri Eristya Maya 
Published: November 2022

Pandemi Covid-19 menyebabkan pergeseran aktifitas manusia ke arah digitalisasi. UU ITE digunakan sebagai kontrol untuk memberikan kewajiban dan memberikan hak dari tiap-tiap Individu yang menggunakan Internet di Indonesia. Masyarakat Indonesia sebagai pengguna Internet yang awam terkadang belum paham betul aturan-aturan yang telah diatur pada UU ITE ini sehingga pada saat menggunakan Internet secara tidak sengaja Masyarakat tersebut melakukan pelanggaran-pelanggaran atau bahkan beberapa oknum sengaja menggunakan teknologi Internet ini secara melawan hukum. Tujuan pengabdian ini yaitu untuk meningkatkan kesadaran dan edukasi terhadap remaja-remaja Indonesia yang merupakan agen perubahan tentang penggunaan internet dengan baik dan benar khususnya di Desa Miru Kabupaten Lamongan. Pengabdian ini bertujuan agar nantinya para remaja ini dapat menggunakan internet dengan aman dan tidak ada indikasi melawan hukum. Metode yang digunakan dalam pengabdian ini yaitu sosialisasi dan pendampingan pembuatan blog. Edukasi penggunaan internet yang sehat dan aman dapat dilakukan dengan memanfaatkan blog berbasis Internet of Things. Blog ini nantinya akan menjadi media dalam penyebaran informasi internet sehat dan informasi lainnya seputar hukum siber di Indonesia sehingga para pengunjung dari blog tersebut dapat teredukasi dan wawasan mengenai cara penggunaan internet yang baik dan tidak melawan hukum bertambah.

Increasing Awareness of Healthy Internet Using Internet of Things-Based Blog for Youth in Miru Village-Lamongan Regency
The Covid-19 pandemic has caused a shift in human activity towards digitalization. The ITE Law is used as a control to provide obligations and give rights to each individual who uses the Internet in Indonesia. Indonesian people as ordinary Internet users sometimes do not understand the rules that have been regulated in the ITE Law so when they use the Internet they accidentally commit violations or even some people intentionally use this Internet technology against the law. The purpose of this service is to increase awareness and education of Indonesian teenagers who are agents of change about using the internet properly and correctly, especially in Miru Village, Lamongan Regency. This service is intended so that later these teenagers can use the internet safely and there is no indication that they are against the law. The method used in this service is socialization and mentoring for blog creation. Education on healthy and safe internet usage can be done by utilizing Internet of Things-based blogs. This blog will later become a medium for disseminating healthy internet information and other information about cyber law in Indonesia so that visitors from the blog can be educated and gain insight into how to use the internet properly and not against the law.
Characteristics of the severe acute respiratory syndrome coronavirus 2 omicron BA.2 subvariant in Jilin, China from March to May 2022
Authors: Liu Han , Wang Shuai , Yang Siqi , Luo Sean X. , Jie Jing , Hua Shucheng , Peng Liping , Luo Jingjing , Song Lei , Li Dan 
Published: November 2022

Abstract

Background and Objectives
In the midst of the pandemic, new coronavirus mutants continue to emerge; the most relevant variant worldwide is omicron. Here, patients who recovered from the disease living in Jilin Province were analyzed to identify factors affecting the severity of omicron infection and to provide insights into its spread and early indication.

Methods
In this study, 311 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were divided into two groups. Data on the patients’ demographic characteristics and laboratory tests, including platelet count (PLT), neutrophil count (NE), C-reactive protein (CRP), serum creatinine (SCR), and neutrophil-to-lymphocyte ratio (NLR), were collected. The biomarkers for moderate and severe coronavirus disease 2019 (COVID-19) and factors affecting the incubation period and time to subsequent negative nucleic acid amplification test (NAAT) were also investigated.

Results
Age, gender, vaccination, hypertension, stroke, chronic obstructive pulmonary disease (COPD)/chronic bronchitis/asthma, and some laboratory tests were statistically different between the two groups. In the receiver operating characteristic (ROC) analysis, PLT and CRP had higher area under the ROC curve values. In the multivariate analysis, age, hypertension, COPD/chronic bronchitis/asthma, and CRP were correlated with moderate and severe COVID-19. Moreover, age was correlated with longer incubation. In the Kaplan-Meier curve analysis, gender (male), CRP, and NLR were associated with longer time to subsequent negative NAAT.

Conclusions
Older patients with hypertension and lung diseases were likely to have moderate or severe COVID-19, and younger patients might have a shorter incubation. A male patient with high CRP and NLR levels might take more time to turn back negative in the NAAT.
بالمقارنة ، الانتشار المناعي لفيروس سرطان الدم البقري في عينات دم وحليب الابقار باستعمال تقنية الايديكس اليزا
Authors: الصافي زيد حسن 
Published: November 2022

فيروس سرطان الدم البقري هو مسبب مرضي سرطاني يصيب سلالة الخلايا اللمفية البقرية B-cell ويؤدي الى مرض كامن لفترة طويلة . في هذه الدراسة ، خضعت بالاجمال (92) بقرة الى جمع عينات الدم ، التي من ضمنها (44) بقرة مدرة للحليب خضعت ، اضافيا ، الى جمع عينات الحليب ، وبعد ذلك خضعت كلا العينتين لاختبار الايديكس اليزا المصلي الذي يستعمل لاول مرة في العراق . كشفت نتائج الانتشار المصلي الكلية بان 14.13 % من عينات الدم و 6.82 % من عينات الحليب كانت موجبة مصليا . فيما يتعلق بعامل الجنس ، كان معدل الاصابة الموجبة مصليا هو 7.41 % و 16.92 % للذكور والاناث ، على التوالي ، اما فيما يتعلق بعامل العمر ، كانت نتائج الاصابة الموجبة مصليا للمجاميع العمرية ( ≥1- 3 ) ، (3 - 5 ) و ( > 5 ) هي 3.23 % ، 10.81 % و 33.33 % ، على التوالي . احصائيا ، سجلت الاختلافات المعنوية فيما بين النتائج الموجبة مصليا لكلا العينتين المختبرتين ( الدم والحليب) ، اضافة الى ذلك ، داخل مجاميع الجنس والمجاميع العمرية عند مستوى (P≥ 0.05).
Prenatal Nutrition Care in Alberta: The Perspectives of Pregnant Women and Registered Dietitians
Authors: Misita Dragana , Aulakh Sharan , Jain Venu , Quintanilha Maira , Ospina Maria B. , Bell Rhonda C. 
Published: November 2022

Introduction: Optimizing women’s diets in pregnancy improves maternal and child health outcomes; however, the best format for supporting women’s nutrition goals in pregnancy is not clear, and access to dietetic services is not standard in prenatal care in Alberta. This study explored women’s perceptions about access to Registered Dietitians (RDs) throughout pregnancy and RDs experiences providing prenatal nutrition counselling. Methods: Two studies were conducted. Study A: Pregnant women completed a short survey while attending a prenatal appointment in a large prenatal clinic. The survey assessed women’s perspectives about accessing dietetic services during pregnancy. Survey data were analyzed using descriptive statistics. Study B: RDs participated in either a semi-structured phone interview or a focus group and described their experiences working with pregnant women. Data were analyzed using thematic analysis. Results: One hundred pregnant women completed the survey. Ninety percent indicated that they had not seen a RD at this time in pregnancy, and 48% reported that they would like to access a RD in pregnancy, if available. Dietitians discussed the diversity of women’s concerns and the challenges to providing prenatal nutrition support. Conclusions: Women have nutrition-related questions during pregnancy. Dietitians experience challenges providing services in the current care systems.
Soft isomorphism for digital images and computational topological applications
Authors: Öztunç Simge , İhtiyar Sultan 
Published: November 2022

In this paper the concept of soft continuity is focused on for digital images by using soft sets which is defined on κ - adjacent digital images. Also the definitions of digital soft isomorphism and digital soft retraction are given. Some theorems are obtained deal with soft isomorphism and soft retraction for digital images and some numerical examples are presented in dimension 2. Finally digital soft retraction is obtained as a soft topological invariant.
The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals
Authors: Haag Laura , Richardson Janice , Cunningham Yvonne , Fraser Heather , Brosnahan Naomi , Ibbotson Tracy , Ormerod Jane , White Chris , McIntosh Emma , O'Donnell Kate , Sattar Naveed , McConnachie Alex , Lean Michael E. J. , Blane David N. , Combet Emilie 
Published: November 2022

Objectives: The Remote Diet Intervention to Reduce Long COVID Symptoms Trial (ReDIRECT) evaluates whether the digitally delivered, evidence-based, cost-effective Counterweight-Plus weight management programme improves symptoms of Long COVID in people with overweight/obesity. Methods: Baseline randomised, non-blinded design with 240 participants allocated in a 1:1 ratio either to continue usual care or to add the remotely delivered Counterweight-Plus weight management programme, which includes a Counterweight dietitian supported delivery of 12 weeks total diet replacement, food reintroduction, and long-term weight loss maintenance. Randomisation is achieved by accessing a web-based randomisation system incorporated into the study web portal developed by a registered Clinical Trials Unit. We are using an innovative approach to outcome personalisation, with each participant selecting their most dominant Long COVID symptom as their primary outcome assessed at six months. Participants in the control arm enter the weight management programme after six months. We are recruiting participants from social media and existing networks (e.g., Long COVID Scotland groups), through newspaper advertisements and from primary care. Main inclusion criteria: people with Long COVID symptoms persisting > three months, aged 18 years or above, body mass index (BMI) above 27kg/m2 (>25kg/m2 for South Asians). The trial includes a process evaluation (involving qualitative interviews with participants and analysis of data on dose, fidelity and reach of the intervention) and economic evaluation (within-trial and long-term cost-utility analyses). Anticipated results: The recruitment for this study started in December 2021 and ended in July 2022. Project results are not yet available and will be shared via peer-reviewed publication once the six-months outcomes have been analysed. Trial registration: Current Controlled Trials ISRCTN12595520
Clinical presentation and in-hospital outcomes of intraoperative red blood cell transfusion in non-anemic patients undergoing elective valve replacement
Authors: Zhou Ren , Qian Dewei , Li Haiqing , Wang Zhe , Shi Sheng , Shen Feng , Cheng Lin , Yang Dicheng , Yu Min 
Published: November 2022

BackgroundIntraoperative transfusion is associated with adverse clinical outcomes in cardiac surgery. However, few studies have shown the impact of intraoperative red blood cell (RBC) transfusion on non-anemic patients undergoing cardiac surgery. We assessed the in-hospital clinical outcomes of non-anemic patients undergoing isolated valve replacements and investigated the predictors associated with intraoperative RBC transfusion.MethodsWe enrolled 345 non-anemic patients undergoing isolated valve replacements in our department from January 2015 to December 2019. The patients were stratified by the receipt of intraoperative RBC transfusion. Baseline characteristics were compared between groups and multiple logistic regression was used to identify the predictors for intraoperative RBC transfusion. The association between intraoperative RBC transfusion and in-hospital outcomes was also evaluated.ResultsIntraoperative RBC transfusion developed in 84 of the 345 enrolled patients (24.3%). Three independent predictors for intraoperative RBC transfusion of non-anemic patients undergoing isolated valve replacements were identified by multivariate logistic analysis, including female, iron deficiency and hemoglobin level. When the two groups were compared, a significant tendency of higher in-hospital mortality (6.0% vs. 1.1%,P= 0.033) and higher incidence of postoperative hypoxemia (9.5% vs. 2.7%,P= 0.007) were observed in the intraoperative RBC transfusion group. After adjustment, the presence of intraoperative RBC transfusion was associated with an increase in postoperative hypoxemia (OR = 3.36, 95% CI: 1.16–9.71,P= 0.026).ConclusionIntraoperative RBC transfusion was associated with poorer clinical outcomes in non-anemic adults undergoing isolated valve replacements, which significantly increased the risk of postoperative hypoxemia. The independent predictors of intraoperative RBC transfusion, such as iron deficiency and female, were identified, which may be helpful for risk assessment and perioperative management.