bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Oxidation Processes against p-Amino Benzoic Acid in Groundwater Samples
Authors: Gautam Anupam Kumar 
Published: July 2022

Abstract
Organic waste from four groundwater sources near an oil refinery in Vadodara, India, was analysed using a spectrophotometer to identify phenolic chemicals. The average concentration of phenolic compounds in these samples was 0.38 mg L-1 using the Folin technique. It was discovered that p-aminobenzoic acid was the most common form of phenolic contamination in the samples. The breakdown of these compounds in soil and the activity of bacteria, which can lead to the construction of structures more resistant to different kinds of oxidation, is the focus of current environmental research on removing p-aminobenzoic acid from real water samples. Using a 2 mg L-1 laboratory sample of different aromatic chemicals to assess the efficiency of AOP in eliminating p-aminobenzoic acid from the groundwater sources under investigation is necessary. Actual samples must be analysed for O3/UV and O3/UV/H2O2 in each of these methods (5000 mg L-1 H2O2, 15 min UVC, 2 mg L-1 O3, 15 min UVC). For actual samples, the average removal rate was 79.52 percent, whereas the average removal rate for lab samples was just 79.52%. The O3/UV approach appears to be the most cost-effective, simplest to deploy, and safest solution for large-scale projects, according to the research.
HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: A case report and literature review
Authors: Zhang Mengmeng , Liu Hui , Zhu Zhiqiang , Zhang Yu , Zhang Yanyan , Hu Xiaopeng 
Published: July 2022

Abstract
Background: Inflammatory myofibroblastic tumor (IMT) is a rare disease that mostly occurs in younger people and is located in the lungs in the general population. We report a rare case of adrenal IMT in a patient with HIV infection, which is believed to be the first of its kind worldwide.Case presentation: We present a rare case of a 44-year-old man with HIV infection who was diagnosed with adrenal IMT. The patient refused regular highly active antiretroviral therapy 13 years ago until he was admitted to hospital after an adrenal mass was found. The patient underwent successful computed-tomography-guided needle biopsy, and pathological analysis showed fibroblastic–myofibroblastic proliferation with inflammatory infiltration, which confirmed a diagnosis of IMT. We failed to perform complete resection of the tumor because of its diffuse invasion. The patient was complicated with severe multiple pulmonary infections postoperatively because of immunodeficiency, which eventually caused his death 2 months later.Conclusion: Differential diagnosis of IMT is difficult, and tumor biopsy is an important means of diagnosis. Surgical resection is preferred for both adrenal and HIV-related IMTs. Conservative treatment should be considered when there are technical difficulties with complete resection, and most patients have achieved good outcomes. However, more cases and longer follow-up are warranted to confirm long-term outcomes of HIV-related IMT.
Pain-coping scale for children and their parents: a cross-sectional study in children with juvenile idiopathic arthritis and other causes of musculoskeletal pain
Authors: Backström Maria , Vuorimaa Hanna , Tarkiainen Maarit , Löyttyniemi Eliisa , Kröger Liisa , Aalto Kristiina , Rebane Katariina , Markula-Patjas Kati , Malin Merja , Sard Sirja , Keskitalo Paula , Korkatti Katja , Grönlund Minna-Maija , Möttönen Milja , Pohjankoski Heini , Hietanen Maiju , Kärki Johanna , Vähäsalo Paula 
Published: July 2022

Abstract
Background
In a chronic pain-causing disease such as juvenile idiopathic arthritis, the quality of coping with pain is crucial, and parents have a substantial influence on their children’s pain-coping strategies. This study aimed to develop scales for assessing parents’ strategies for coping with their children’s pain and a shorter improved scale for children usable in clinical practice.
Methods
The number of items in the Finnish version of the pain-coping questionnaire was reduced from 38 to 20. A corresponding scale was created for parental use. We recruited consecutive patients aged 8–16 years who visited a paediatric rheumatology outpatient clinic and reported musculoskeletal pain during the past week. The patients and parents rated the child’s pain on a visual analogue scale from 0 to 100 and completed pain-coping questionnaires and depression inventories. The selection process of pain questionnaire items was performed using factor analyses.
Results
The study was conducted in nine hospitals evenly distributed throughout Finland. The average (standard deviation) age of the 130 patients was 13.0 (2.3) years; 91 (70%) were girls. Four factors were retained in the new, improved Pain-Coping Scales for children and parents. Both scales had 15 items with 2–5 items/factor. All analytic assumptions of the factor analyses were fulfilled.
Conclusions
We created a shorter, feasible pain-coping scale for children and a novel scale for caregivers. Both showed good validity and reliability. In clinical work, the pain coping scales may serve as a visualisation of different types of coping resources for paediatric patients with pain and their parents and facilitate the identification of families in need of psychological support.
Determination of chlorantraniliprole 18.5% SC in the paddy ecosystem and its risk assessment
Authors: Mahato Saraswati , M Bheemanna , R Harischandra Naik , Hurali Sujay , Pallavi M S , Rao Saroja N , M Nagaraj Naik , Paramsivam M 
Published: July 2022

Abstract
Supervised field trials were conducted during rabi and kharifseasons to evaluate the dissipation pattern of chlorantraniliprole 18.5% SC in the paddy ecosystem. Modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method was used for the extraction and clean-upof chlorantraniliprole residues and determined using LC-MS/MS in the ESI positive mode. The limit of quantification (LOQ) was 0.01 µg g− 1for paddy leaf, straw, husk, and brown rice, and for soil was 0.005 µg g− 1. The obtained average recoveries were 84.30–88.92%, 94.25–97.81%, 90.21–93.38%, 93.57–96.40% and 89.93–91.14% from paddy leaf, straw, husk, brown rice and soil, respectively. The relative standard deviation was less than 9% in all the matrices. The residues in paddy leaf dissipated within 35 to 40 days with a half-life of 4.33–5.07 days in rabi and 3.92– 4.86 days in kharifat 30 and 60 g a.i. ha− 1, respectively. The residues in soil dissipated within 15–21dayswith a half-life of 14.44–15.75 and 13.33–14.44 days in rabi and kharif season, respectively. At harvest, chlorantraniliprole residues were not detected in straw, husk, and brown rice. The dietary risk of paddy leaf (green fodder) for cattle was found safe for consumption as the hazard index is less than one. Soil ecological risk assessment was found to be less than one (RQ < 0.1) for earthworms and arthropods.
Prevalence and risk factors determinants of the non-use of insecticide-treated nets in an endemic area for malaria: analysis of data from Cameroon
Authors: Kuetche Magloire T.C. , Tabue Raymond N. , CD Fokoua-Maxime , Evouna Armel M. , Billong Serge , Kakesa Olivier 
Published: July 2022

Abstract
BackgroundMalaria is the main cause of morbidity and mortality in Cameroon. Insecticide-treated nets (ITNs) significantly reduce malaria transmission, but their use is not common among populations. This study aimed to estimate the prevalence of the non-use of ITNs and identify its major determinants.Methods A cross-sectional study was conducted on interview data collected in households selected across all the regions of Cameroon through a non-probabilistic, random, 2-stage stratified sampling process. Descriptive statistics were used to describe the distribution of baseline characteristics across the households, and statistical tests assessed if the distribution of these characteristics differed significantly based on the non-use of ITNs, with 0.05 serving as a threshold of the p-value for statistical significance. The prevalence of the non-use of ITNs was estimated, and logistic regression models were used to tally the odds ratios of the associations between various factors and the non-use of ITNs, along with their 95% confidence intervals. Sensitivity, specificity, and areas under the curves were also determined, and the Hosmer Lemeshow test was used to measure the goodness of fit of each statistical model. Results Of the 7593 households interviewed, 77% had at least one ITN and 59% of the population used ITNs. Only 72% of the population with at least one ITN actually used it. The logistic model of the Multivariate analysis was significant at 5%. The area under the receiver operating characteristic (ROC) curve was 0.7087 and the error rate was 18.01%. The sensitivity and specificity of the model were 97.56% and 13.70% respectively. The factors that were associated with ITN use were the presence of sufficient nets in the household ( p <0.0001), the region of residence (p< 0.0001), the level of education of the respondent (p < 0.0001) and the standard of living (p=0.0286). Sex, age, colour preferences, as well as the shape and size of the net were not associated with ITN use.ConclusionsThe use of ITNs was low and varied according to specific factors. These identified factors could be used as the foundations of effective sensitization campaigns on the importance of ITNs.
Metagenomic Next-Generation Sequencing for the Diagnosis of Pneumocystis jirovecii Pneumonia in Critically pediatric patients: A Retrospective Study
Authors: Chen Hengxin , Liang Yujian , Wang Ruizhi , Wu Yijie , Zhang Xiaoyun , Huang Hao , Yu Xuegao , Hong Mengzhi , Liao Kang , Xu Hongxu , Liu Min , Chen Peisong , Chen Yili 
Published: July 2022

Abstract
Objective The aim of this study was to evaluate the effectiveness of metagenomic next-generation sequencing (mNGS) for the diagnosis of Pneumocystis jirovecii Pneumonia(PJP) in critically pediatric patients. Methods Seventeen critically pediatric patients with PJP and 60 patients diagnosed with non-PJP pneumonia who were admitted in pediatric intensive care unit between June 2018 to July 2021 were enrolled. Conventional methods and mNGS for detecting Pneumocystis jirovecii (P. jirovecii) were analyzed. The patients' demographics, comorbidities, laboratory parameters, treatments and 30-days mortality were compared. Results MNGS showed a satisfying diagnostic performance with a sensitivity of 100% in detecting P. jirovecii compared to Gomori Methenamine silver staining(5.9%) and serum (1,3)-β-D-glucan(86.7%). The diagnostic specifificity of mNGS for PJP was higher than that of serum BDG(56.7%). In PJP cohort, over one thirds' cases had mixed infections. Compared with survivors, non-survivors had higher stringently mapped read numbers(SMRNs) in BALF(P < 0.05), suggesting SMRNs may play a potential role in the severity of response. The detection for P. jirovecii by mNGS both in BALF and blood reached a concordance rate of 100%,and the SMRNs in the BALF were remarkably higher than that in blood samples. Initial antimicrobial treatment was modifified in 88.2% of PJP patients based on the mNGS results. Conclusion MNGS is a potential and efficient technology in diagnosing PJP and shows a satisfying performance in the detection of co-pathogens. Both blood and BALF samples for mNGS are suggested for the presumptive diagnosis of PJP.
Mapping of resistance loci in wheat line Milan/S87230//Babax to South African races of Puccinia striiformis f. sp. tritici
Authors: Prins Renée , de Klerk Corneli , Boshoff Willem H.P. , Bender Cornel M , Pretorius Zacharias A , Botha Kirsty S , Wessels Elsabet 
Published: July 2022

Abstract

The continuous emergence of new Puccinia striiformis Westend f. sp. tritici Erikss (Pst) races requires a sustained search for useful sources of resistance. A CIMMYT bread wheat line (pedigree: Milan/S87230//Babax; renamed NSRPan4) was identified as highly resistant to South African Pst races. A recombinant inbred line (RIL) mapping population was developed by crossing NSRPan4 with Avocet S. Stripe rust data collected for RILs, using Pst race 6E22A+, include seedling infection types determined under controlled conditions as well as adult plant responses determined in field trials over three consecutive seasons. Quantitative trait loci (QTL) mapping identified stripe rust resistance genes/QTL on chromosomes 2A and 2B, temporarily designated as QYr.ufs-2A.2(Yr17) and QYr.ufs-2B.1, respectively. The QTL interval on chromosome 2A, which includes the Lr37/Yr17/Sr38 gene complex (also referred to as the 2NS/2AS or 2NVS segment), conferred a significant seedling (R2 23.5%) and adult plant resistance effect (R2 up to 54.5%). The QTL on 2B contributed up to 46.4% of phenotypic variance observed. Three minor QTL, temporarily designated as QYr.ufs-1B.1 (possibly Lr46/Yr29), QYr.ufs-3D.1 and QYr.ufs-7A.1 were also detected. Our results support findings that notwithstanding the reported virulence for Yr17, the Lr37/Yr17/Sr38 segment remains useful in combination with other sources of resistance in certain genetic backgrounds and environments. Together with QYr.ufs-2B.1 and in the presence of the detected minor QTL and yet unidentified resistances, it was a consistent major contributor to the high level of stripe rust resistance in NSRPan4 to South African races of Pst.
Maternally Inherited Diabetes and Deafness (MIDD) - a Series of Case Reports
Authors: SureshKumar Pichakacheri , Radha Venkatesan , Mohan Viswanathan , Kumar Sidharth S , Babu Aishwarya Suresh 
Published: July 2022

Abstract
Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes, caused by a mutation in the mitochondrial DNA (mtDNA) which impairs mitochondrial function by decreasing the efficiency of the Leucine Transfer ribonucleic acid (tRNA) in adding amino acids to developing proteins. MIDD has a prevalence of 0.5–3% among diabetic population but almost always misdiagnosed and managed as either Type 1 or Type 2 diabetes mellitus, which adversely impacts their long term outcome. So it is important to differentiate these cases early enough and to institute correct treatment. We report on 3 cases of MIDD which was confirmed by genetic testing and five of their first degree relatives with similar clinical presentation. A heteroplasmic missense mutation in the MT-TL1 gene (chrm: 3243A > G mitochondrial DNA) was detected in all three patients but genetic confirmation was not possible in their relatives for want of patient consent for genetic study. To our knowledge, this is the largest series of MIDD reported from India.
Role of Fine Silica as Amorphous Solid Dispersion Carriers for Enhancing
Drug Load and Preventing Recrystallization- A Comprehensive Review
Authors: Trivedi Rishab , Chatterjee Bappaditya , Kalave Sana , Pandya Mrugank 
Published: July 2022

Abstract:
Amorphous solid dispersion (ASD) is a popular concept for improving the dissolution and
oral bioavailability of poorly water-soluble drugs. ASD faces two primary challenges of low drug loading
and recrystallization upon storage. Several polymeric carriers are used to fabricate a stable ASD
formulation with a high drug load. The role of silica in this context has been proven significant. Different
types of silica, porous and nonporous, have been used to develop ASD. Amorphous drugs get entrapped
into silica pores or adsorbed on their surface. Due to high porosity and wide surface area, silica
provides better drug dissolution and high drug loading. Recrystallization of amorphous drugs is inhibited
by limited molecular ability inside the delicate pores due to hydrogen bonding with the surface silanol
groups. A handful of researches have been published on silica-based ASD, where versatile types
of silica have been used. However, the effect of different kinds of silica on product stability and drug
loading has been rarely addressed. The present study analyzes multiple porous and nonporous silica
types and their distinct role in developing a stable ASD. Emphasis has been given to various types of
silica which are commonly used in the pharmaceutical industry.
A Systematic Review of Systematic Reviews Exploring the Factors Related to Child and Adolescent Self-Harm
Authors: Varley Danielle , Fenton Clare , Gargan Georgina , Taylor Olivia , Taylor Amelia , Kirby Natalie , Morton Michael , Barrow Jamie , Hatton Christopher , Wright Barry 
Published: July 2022

Background:In recent years, the rates of young people presenting with self-harming have increased dramatically, with self-harm being a predictor of suicide. Despite evidence suggesting that self-harm is common in young people and that hospital admissions are increasing, research exploring the reasons behind young people’s motivations is not easily accessed. Systematic reviews have explored this from a range of perspectives, but none have drawn all this literature together.Methods:A systematic review of systematic reviews was conducted in accordance with PRISMA guidelines. Seven databases were searched using a peer reviewed search strategy, with a focus on the factors of child and adolescent self-harming. All English language articles, published between 2008 and 2021, were considered, and screened against inclusion criteria. References of included articles were also searched for eligible articles.Results:Twenty-two systematic reviews were included after screening against eligibility criteria. Narrative synthesis identified eight themes for motivation or reasons for self-harming: identity and subcultures, peer influences, educational stressors, mental ill health, cognitive and neuropsychological factors, trauma and attachment, internet influences and social media.Conclusion:Reasons for self-harming in adolescents are complex and multifactorial. Many studies focus on single causes or associations with self-harm rather than open-mindedly exploring a range of factors or the interactions between them. This leaves gaps in the research where hypothetical reasons for self-harm have not been systematically explored. The themes identified here could help in the clinical assessment process and guide future research in this area, including the development of potential differentiated prevention and treatment approaches.
Exploring an Artificial Intelligence–Based, Gamified Phone App Prototype to Track and Improve Food Choices of Adolescent Girls in Vietnam: Acceptability, Usability, and Likeability Study
Authors: C Braga Bianca , Nguyen Phuong H , Aberman Noora-Lisa , Doyle Frank , Folson Gloria , Hoang Nga , Huynh Phuong , Koch Bastien , McCloskey Peter , Tran Lan , Hughes David , Gelli Aulo 
Published: July 2022

Background
Adolescents’ consumption of healthy foods is suboptimal in low- and middle-income countries. Adolescents’ fondness for games and social media and the increasing access to smartphones make apps suitable for collecting dietary data and influencing their food choices. Little is known about how adolescents use phones to track and shape their food choices.

Objective
This study aimed to examine the acceptability, usability, and likability of a mobile phone app prototype developed to collect dietary data using artificial intelligence–based image recognition of foods, provide feedback, and motivate users to make healthier food choices. The findings were used to improve the design of the app.

Methods
A total of 4 focus group discussions (n=32 girls, aged 15-17 years) were conducted in Vietnam. Qualitative data were collected and analyzed by grouping ideas into common themes based on content analysis and ground theory.

Results
Adolescents accepted most of the individual- and team-based dietary goals presented in the app prototype to help them make healthier food choices. They deemed the overall app wireframes, interface, and graphic design as acceptable, likable, and usable but suggested the following modifications: tailored feedback based on users’ medical history, anthropometric characteristics, and fitness goals; new language on dietary goals; provision of information about each of the food group dietary goals; wider camera frame to fit the whole family food tray, as meals are shared in Vietnam; possibility of digitally separating food consumption on shared meals; and more appealing graphic design, including unique badge designs for each food group. Participants also liked the app’s feedback on food choices in the form of badges, notifications, and statistics. A new version of the app was designed incorporating adolescent’s feedback to improve its acceptability, usability, and likability.

Conclusions
A phone app prototype designed to track food choice and help adolescent girls from low- and middle-income countries make healthier food choices was found to be acceptable, likable, and usable. Further research is needed to examine the feasibility of using this technology at scale.
The Effects of Information Continuity and Interpersonal Continuity on Physician Services Online: Cross-sectional Study
Authors: Xuan Yan , Guo Chaojin , Lu Wei 
Published: July 2022

Background
Web-based medical services have become an effective supplement to traditional services in hospitals and an essential part of medical services. Studies have shown that web-based medical services are useful for shortening the delayed admission time and for enhancing the treatment effect from the service continuity perspective. However, the specific measures that patients and physicians should take to improve service continuity remain unknown.

Objective
Based on the information richness theory and continuity of care, this study investigates the dynamic effects of information continuity and interpersonal continuity on physician services online.

Methods
Data of 7200 patients with 360 physicians covering complete interaction records were collected from a professional web-based platform in China. Content analysis was performed to recognize matching patients and physicians, and least square regression analysis was performed to obtain all empirical results.

Results
Empirical results showed that in the short term, information continuity (including offline experience, medical records, and detailed information) influences physicians’ web-based services, and their influences show heterogeneity. Moreover, if a patient’s online physician is the same physician who he/she has visited offline, we find that interpersonal continuity is important for service. In the long term, information continuity and interpersonal continuity positively improve service continuity by facilitating repeat purchases.

Conclusions
Overall, our findings not only shed new light on patient behavior online and cross-channel behavior but also provide practical insights into improving the continuity of care in online health communities.