bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of developing dialysis-requiring acute kidney injury on long-term mortality in cancer patients with septic shock
Authors: Kim June-sung , Kim Youn-Jung , Kim Ye-Jee , Kim Won Young 
Published: April 2022

Abstract
Background: Sepsis-related acute kidney injury is associated not only with short-term adverse effects but also important long-term consequences. However, differences and results across cancer patients remain unknown. Considering recent advances in both cancer and sepsis management, we were to evaluate the associated factors for occurrence of septic AKI and to determine the impact of septic acute kidney injury on the long-term mortality in cancer patients using a nationwide population-based cohort data with prohibited withdrawal of life-sustaining therapy.Methods: Using data from the National Health Insurance Service of Korea, adult cancer patients who presented to emergency department with septic shock from 2009 to 2017 were analyzed. Cox-proportional hazard model was conducted to evaluate the clinical effect of sepsis-related acute kidney injury requiring dialysis on the 2-year mortality.Results: Among 42,477 adult cancer patients with septic shock (90% solid and 10% hematologic cancer cases), dialysis-requiring acute kidney injury occurred in 5449 (12.8%) admission. Recovery from dialysis within 30-day was 77.9% and overall, 30-day and 2-year mortality rates were 52.1% and 85.1%, respectively. Oncologic patients with dialysis-requiring acute kidney injury were frequently occurred in male, history of hypertension, diabetes, congestive heart failure, liver cirrhosis, and patients with hematologic cancer. In multivariate Cox-proportional hazard model showed that dialysis-requiring acute kidney injury had a highest adjusted hazard ratio of 1.5 (95% confidence interval 31.31–1.40) for 2-year mortality.Conclusion: Dialysis-requiring septic acute kidney injury is not occurred commonly (about 13%). However, it had a significant association with the increased long-term mortality which emphasis on the prevention of acute kidney injury particularly in male hematologic cancer patients with comorbidities among the oncologic population.
Accuracy of axial length, keratometry, and refractive measurement with Myopia Master in children with ametropia
Authors: Ye Yuhao , Zhao Yu , Han Tian , Zhang Xiaoyu , Miao Huamao , Qin Bing , Zhou Xingtao 
Published: April 2022

Abstract
Purpose: To evaluate the accuracy of axial length, keratometry, and refractive measurement with Myopia Master in ametropic children.Methods: In this randomized prospective cross-sectional study, 125 children with ametropia (250 eyes) were recruited (55 boys and 70 girls; age range: 3–15 years). All examinations were performed under full cycloplegic conditions. Measurements of axial length (AL), keratometry, and autorefraction acquired with the Myopia Master were compared with those from the IOLMaster 500, IOLMaster 700, Nidek ARK-1, and manifest refraction. The differences between the different methods were analyzed, and their correlation was assessed by interclass correlation coefficients (ICCs), Bland-Altman plot, and correlation test.Results: The ALs (mm) measured with Myopia Master, IOLMaster 500, and IOLMaster 700 were 23.67 ± 1.26, 23.68 ± 1.26, and 23.70 ± 1.25, respectively. The mean values and standard deviations for AL and keratometry readings from these devices were similar (P ≥ 0.059). The ICC analysis also revealed high consistency between the measurements (ICC ≥ 0.943). Additionally, the correlation coefficients were relatively high (r > 0.9, p < 0.001). Although the results of refraction obtained with the Myopia Master were slightly higher than those with manifest refraction (P ≤ 0.024), the agreement between these two measurements was excellent (ICC ≥ 0.858). The percentage of points outside the limits of agreements was < 5.22% in Bland-Altman plots for all analyses.Conclusions: Myopia Master could be a highly efficient tool for clinical use as a three-in-one system (AL, keratometry, and refractive measurements) for screening in children with ametropia.
Anti-fibrotic and antioxidant ameliorative effect of Naringenin against thioacetamide induced liver fibrosis
Authors: Ali Haytham , Afifi Mohamed 
Published: April 2022

Abstract
This work conducted to evaluate the anti-fibrotic and antioxidant role of naringenin (NAR) toward thioacetamide (TAA) induced liver fibrosis. Fifty adult male albino rats randomly divided into 5 groups (10 each); first group kept as control one; the second treated I/P by 200 mg/kg TAA twice a weeks for 8 weeks; the third was gavaged daily with 50 mg /kg/ b.wt of NAR; the fourth was co-treated by TAA and NAR while the fifth was treated with TAA for 8 w then gavaged daily by NAR for 1 month. TAA administration significantly increases the hepatic cell enzymes (ALT, AST, ALP and GGT) in the serum referring to hepatic cell destruction with an increase in hepatic MDA with a reduction in GSH concentrations, antioxidant enzyme activities as well as down regulation of their expression levels. NAR administration either with or after TAA ameliorates this effect suggesting its antioxidant ability. In the fibrotic pathway, TAA treatment up-regulates the expression levels of fibrogenic biomarkers (TGF-β, collagen 1α and fibronectin) genes while NAR down-regulates these genes suggesting its anti-fibrotic ability. Histopathological analysis confirms the biochemical results. In conclusion, NAR ameliorates the deleterious effect of TAA through its antioxidant and anti-fibrotic abilities.
New insight into therapeutic strategy and prognostic predictors in patients with cardiac Behçet's Syndrome: from the Shanghai Behçet's Syndrome database
Authors: Bao Hua-fang , Hou Cheng-cheng , Cai Jian-fei , Jian Kai-tao , Luo Dan , Ye Jing-fen , She Chun-hui , Guan Jian-Long 
Published: April 2022

Abstract
Background
Cardiac Behçet’s syndrome (cardiac BS) is rare but lethal. And the influencing factors of prognoses in cardiac BS are not clear. This study was conducted to summarize the features of cardiac BS and find the predictors of unfavourable prognoses for cardiac BS patients.
Methods
Sixty-six cardiac BS patients were included from 1467 BS patients in the Shanghai Behçet’s syndrome database. The median follow-up duration was 4.0 (2.0–7.0) years. The unfavourable prognosis was defined as a compound event containing all-cause death and rehospitalization related to worsened cardiac lesions or postoperative complications. Logistic regression analyses were performed to evaluate the predictors of unfavourable prognoses.
Results
In this study, the mortality rate of cardiac BS patients was 10.61% (7/66), and 22 (33.33%) patients experienced two or more surgeries. Ninety-six cases were collected from 66 cardiac BS patients. The effective rates of postoperative biological agents and Janus kinases (JAK) inhibitors in cardiac BS patients were 88.89% (16/18) and 81.25% (13/16) respectively. Former smoking, valve replacement or repairment and poor compliance were found to be the independent risk factors of unfavourable prognoses; preoperative immunosuppressive therapies and postoperative immunosuppressive therapies were independent protective factors for unfavourable prognoses in total cardiac BS. In 65 cases of cardiac BS after aortic valve surgeries, former smoking was an independent risk factor for unfavourable prognoses. Bentall procedure, postoperative traditional DMARDs, postoperative JAK inhibitors or biological agents were independent protective factors for unfavourable prognoses in cardiac BS patients after aortic valve surgeries.
Conclusion
Both preoperative immunosuppressive therapies and postoperative immunosuppressive therapies are necessary for cardiac BS patients. Bentall procedure is recommended to be performed in BS patients with severe AR. Besides biological agents, JAK inhibitors can be used in cardiac BS patients after aortic valve surgeries for promoting favourable outcomes.
An assessment of health consequences of Fossil Fuel energy use in Osun State, Nigeria: Burden and Implications
Authors: Akintunde Temitope 'Sade , Akintunde Adeseye Abiodun 
Published: April 2022

Abstract

Background
The use of fossil fuel energy still persists in all continents of the world especially in Africa. This study was aimed to examine fossil fuel energy usage and its health implication on residents of Osun State, Nigeria.
Methods
This was a cross sectional study done across Osun State Nigeria. The study took place between January to June 2020. 1044 participants were recruited by multi stage random sampling. Structured questionnaires were used to obtain necessary information from the study participants. Statistical analysis was done with SPSS 24.0. P < 0.05 was taken as statistically significant.
Results
There were 534 females (51.1%). Fossil fuel energy was common among study participants as 601(57.6%) relied solely on fossil fuel energy compared to 443(42.4%) who uses non-traditional energy sources. There were 534 females (51.1%). Fossil fuel energy was common among study participants as 601(57.6%) relied solely on fossil fuel energy compared to 443(42.4%) who uses modern energy sources. The proportion of people whose annual monthly income is less than one hundred and twenty US Dollars (fifty thousand Naira) is far higher among those who used fossil fuel energy (88.0%) compared to those who used modern energy (59.1%). Electricity consumption accessibility was also more likely among those who used modern energy (91.9%) compared to 52.4% of those that uses fossil fuel energy for daily energy needs.
Conclusion
This study showed that fossil fuel energy use is very prevalent among residents of Osun State, Nigeria. and is linked with many indices of poverty. It is associated with significant health impact including respiratory diseases and poor quality of life. There is need to encourage and implement policies towards effective and efficient energy use among residents in Osun State to reduce the associated long term health impact.
Comparison of the novel WEst coast System for Triage (WEST) with Rapid Emergency Triage and Treatment System (RETTS) - An observational pilot study
Authors: Habbouche Samah , Carlson Tobias , Johansson Daniel , Kjaerbeck Schani , Malm Mathias , Svensson Per-Arne , Holmqvist Lina 
Published: April 2022

Abstract
Background: The majority of Swedish emergency departments (ED) use the triage system called Rapid Emergency Triage and Treatment System (RETTS), which over time has proven to categorize patients to higher triage levels and thus increasing their waiting time and leads to challenges in identifying high-risk patients. In order to achieve a more balanced triage in relation to actual medical risk, the triage system WEst coast System for Triage (WEST) was developed, based on the South African Triage Scale (SATS). The aim of this study is to perform an initial evaluation of the novel emergency triage system WEST compared with the existing RETTS.Methods: Both RETTS and WEST are five level triage systems illustrated by colors. Nurses from each of the three adult EDs of Sahlgrenska University hospital in Gothenburg and the ambulance service assessed and triaged 1,510 patients according to RETTS and immediately thereafter filled out the WEST triage form. Data from each triage report were analyzed and grouped according to the triage color, chief complaint for the ED visit, and outcome of each patient. Data on discharge categories and events within 72 hours were also collected. Data were analyzed with descriptive statistical methods.Results: In general, WEST displayed lower levels of prioritization compared to RETTS, with no observed impact on patients’ medical outcomes. In the RETTS orange group, approximately 50% of the patients were down prioritized in WEST to yellow or green. In contrast, in the RETTS yellow group, more than 55% were down prioritized to green in WEST. The number of patients who had a serious event during the first 72 hours was few. All three patients who died had red prioritization in RETTS, but two had red and one had orange prioritization when using WEST. All these patients were admitted into the hospital. Conclusions: WEST may reduce over prioritization at the ED, especially in the orange and yellow groups of RETTS, with no observed increase in the medical risks. WEST, thus, can be recommended for clinical comparative study.
Therapeutic potential of pupil coroplasty combined with phacomulsification and intraocular lens implantation against uveitis-induced cataract
Authors: Lu Hui , Chen Doudou , Zhu Siquan 
Published: April 2022

Abstract
Background: Uveitis is a severe intraocular inflammation with high recurrence rate, which can induce cataract. This study aimed to evaluate the therapeutic effect of pupil coroplasty combined with phacomulsification and intraocular lens implantation (PPI) in uveitis-induced cataract.Methods: Total 28 patients with uveitis-induced cataract were enrolled. Within 3 months before the PPI, 7 cases accompanied with glaucoma maintained carteolol hydrochloride for lowering intraocular pressure, and 1 case maintained glucocorticoid for anti-inflammation. The baseline characteristics, treatment processes, and outcomes of enrolled cases were retrospectively analyzed. Hematoxylin and Eosin (HE) staining was performed to reveal the histopathological changes of iris tissues.Results: Iris hemorrhage was the only intraoperative complication observed in 2 cases. After the surgery, normal intraocular pressure, right position of intraocular lens, and improved visual gain (BCVA > 0.5) were achieved. Postoperative keratic precipitates was observed in 2 cases, which was recovered within 1 week. During the follow-up of 5-10 years, no recurrence of uveitis was found in 27 cases (96.43%). Uveitis only recurred in one case with the onset of ankylosing spondylitis. HE staining showed iris stroma (all samples), pigment cell hyperplasia in pigment epithelium (n = 9) and stroma (n = 19), inflammatory cell infiltration in iris (n = 7), and neovascularization in iris surface (n = 2).Conclusion: PPI improved the visual gain and prevented the long-term recurrence of uveitis in patients with uveitis-induced cataract, including those with preoperative intraocular pressure abnormality (glaucoma) and inflammation (active uveitis). Uveitis presented stroma atrophy, pigment cell hyperplasia, and inflammatory cell infiltration, even in a quiet state.
Mitochondrial transfer to host cells from ex vivo expanded donor hematopoietic stem cells
Authors: Kawano Hiroki , Kawano Yuko , Smith Charles O. , LaMere Mark W. , McArthur Matthew J. , Becker Michael W. , Ballinger Scott W. , Gojo Satoshi , Eliseev Roman A. , Calvi Laura M. 
Published: April 2022

Abstract
Mitochondrial dysfunction is observed in various conditions, from metabolic syndromes to mitochondrial diseases. Moreover, Mitochondrial DNA (mtDNA) transfer is an emerging mechanism that enables restoration of mitochondrial function in damaged cells. Hence, developing the technology that facilitates transfer of mtDNA can be a promising strategy for the treatment of these conditions. Here, we utilized an ex vivo culture of mouse hematopoietic stem cells (HSCs) and succeeded in expanding HSCs efficiently. Upon transplantation, sufficient donor HSC engraftment was attained in host. To assess the mitochondrial transfer via donor HSCs, we used mitochondrial-nuclear exchange (MNX) mice with nuclei from C57BL/6J and mitochondria from the C3H/HeN strain. Cells from MNX mice have C57BL/6J immunophenotype and C3H/HeN mtDNA, which is known to confer a higher stress resistance to mitochondria. Ex vivo expanded MNX HSCs were transplanted into irradiated C57BL/6J mice and the analyses were done at six weeks post transplantation. We observed high engraftment of donor cells in peripheral blood as well as in bone marrow. We also found that HSCs from the MNX mice could transfer mtDNA to host cells. This work highlights the utility of ex vivo expanded HSC to achieve the mitochondrial transfer from donor to host in the transplant setting.
Different rhizosphere soil microbes are recruited by tomatoes with different fruit color phenotypes
Authors: Chen Siyu , Sun Yan , Wei Yufei , Li Huan , Yang Shangdong 
Published: April 2022

Abstract
Background: To explore and utilize abundant soil microbes and their beneficial functions, the bacterial and fungal compositions in rhizospheres between red- and yellow-fruited tomato varieties were analyzed using high-throughput sequencing technique.Result: Our results indicated that different soil microbes in rhizospheres of tomatoes were exactly recruited by different color fruit tomatoes. For the reasons as not only soil bacterial community, but also soil fungal compositions were all different between red and yellow fruit tomatoes. For example, Acidibacter, norank_f_norank_o_Vicinamibacterales, unclassified_f__Bacillaceae, norank_f_JG30-KF-AS9, Planifilum, norank_f_norank_o_Subgroup_2, Streptomyces, Nocardioides, norank_f_norank_o_IMCC26256, and norank_f_67-14 were the specific dominant soil bacterial genera, and unclassified_f_Pyronemataceae and unclassified_f_Sordariaceae were the dominant soil fungal genera in the rhizospheres of red tomato varieties. In contrast, norank_f_Birii41, Hyphomicrobium, norank_f_Gemmatimonadaceae and Gaiella were the unique dominant soil bacterial genera, and unique dominant soil fungal genera were not detected in the rhizospheres of yellow tomato varieties. Moreover, a higher abundance of specific soil bacterial and fungal genera in the rhizosphere was found for the red than for the yellow tomato varieties. Conclusion: As tomato fruit color formations are relating to endogenous hormones, and endogenous hormones are partly derived from soil microbes in rhizospheres. According to the different compositions and functions of soil bacteria and fungi were found enriching in rhizospheres of red- and yellow-fruited tomato varieties, it also can be concluded that different soil microbes in rhizospheres exactly are recruited by tomato varieties with different phenotypes related to fruit color formation.
Serum lipidomics reveals novel biomarkers by UHPLC-HRMS to assist the discrimination between colorectal adenoma and cancer
Authors: Chen Hongwei , Zhang Jiahao , Zhou Hailin , Zhu Yifan , Liang Yunxiao , Zhu Pingchuan , Zhang Qisong 
Published: April 2022

Abstract
Purpose
The mechanisms of colorectal adenoma (CA) transforming colorectal cancer (CRC) remain unclear, and there are still lacking biomarkers to distinguish CA from CRC. Hence, this study aimed to explore underlying the mechanisms of CA canceration and novel biomarkers to differentiate CA from CRC.
Methods
An ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) method was employed to measure global lipid profiles of 100 serum samples from CA and CRC patients. Univariate and multivariate statistical analysis were applied to select the differential lipids between two groups. Combining constituent ratio analysis and performance evaluation analysis by the receiver operating characteristic (ROC) curve explored the mechanisms of CA canceration and lipid markers to discriminate CA and CRC.
Results
Serum lipid profiles presented obvious differences between CA and CRC. Totally 85 differential lipids (P < 0.05 and fold change > 1.5) were discovered and mainly involved in fatty acid (FA), phosphatidylcholine (PC), and triacylglycerol (TAG) metabolism with ratio > 63%. 7 lipids served as the putative biomarkers with the area under the curve (AUC) > 0.800. Among them, a lipid panel containing four lipids was selected as the potential biomarkers with excellent performance (AUC = 0.971) and the highest selected frequency to distinguish CA from CRC based on SVM classification model.
Conclusion
The lipid panel could act as the potential biomarkers aiding the early diagnosis of CRC. Metabolic dysregulation of FAs, PCs, and TAGs should be involved in CA canceration, which provides new clues to understand its underlying mechanisms.
The Association Between Respiratory Tract Colonisation with Ureaplasma parvum and Ureaplasma urealyticum and Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns: 11-years retrospective study in a single tertiary centre
Authors: Gobec Katja , Mukenauer Rebeka , Keše Darja , Erčulj Vanja , Grosek Štefan , Perme Tina 
Published: April 2022

Abstract
Purpose. With this 11-year long retrospective study (2009–2019) we wanted to ascertain the incidence of respiratory tract colonisation of extremely low gestational age newborns (ELGANs) with Ureaplasma parvum and Ureaplasma urealyticum and if there is a difference in the severity of bronchopulmonary dysplasia (BPD) between preterm infants with proven respiratory tract colonisation with U. parvum and U. urealyticum and without colonisation, controlled for other risk factors for BPD. Methods. We reviewed the medical records of ELGANs 23 0/7–27 6/7 weeks of gestation, tested for U. parvum and U. urealyticum. The causative Ureaplasma species (spp.) were identified using Mycofast Screening Revolution assay based on liquid broth cultures or with the PCR method. Results. This study included 196 preterm newborns. Fifty (25.5%) newborns had Ureaplasma spp. respiratory tract colonisation, with U. parvum being the predominant species. The results showed a slightly growing incidence rate of respiratory tract colonisation with Ureaplasma spp. in the observed period. The incidence rate for 2019 was 16.2 per 100 infants. We also discovered a statistically significant correlation between the severity of BPD and the colonisation with Ureaplasma spp. (p=0.041). Controlling for other risk factors for BPD in the regression model, the preterm infants colonised with Ureaplasma spp. had 4.32-times (95% confidence interval, CI 1.20–15.49) higher odds for developing moderate to severe BPD. Conclusions. Our results suggest that U. parvum and U. urealyticum could be associated with the development of BPD in ELGANs.
Accuracy of pilot balloon palpation in small sized tubes compared to large sized tubes: A prospective observational study
Authors: Ban MinGi , Kim So Yeon , Kim Min Soo , Park Wyun Kon , Song Sei Han , Skin Dongkwan , Kim Hyun Joo 
Published: April 2022

Abstract
Purpose
After inflating the cuff of the endotracheal tube, the pressure of the cuff should be evaluated as to whether it is appropriate for ventilation. The most commonly used method is pilot balloon palpation. This study evaluated whether the size of the tracheal tube influenced the accuracy of pilot balloon palpation.
Methods
A prospective observational analysis of 208 patients intubated with an endotracheal tube of internal diameter (ID) 6.0 or 8.0 was conducted. An anesthesiologist first judged whether the cuff pressure was appropriate by manual pilot balloon palpation, and then measured the cuff pressure with a pressure gauge. If the cuff pressure exceeded 20–30 cmH2O, it was defined as a false recognition.
Results
The intracuff pressure was significantly higher in ID 6.0 tube than in the ID 8.0 tube (41.9 ± 18.8 cmH2O vs. 30.3 ± 11.9 cmH2O, p < 0.001). The number of patients that were mistakenly perceived to have appropriate cuff pressure by pilot balloon palpation was significantly higher in the ID 6.0 group compared to the ID 8.0 group (85 (81.7%) vs. 64 (61.5%), p = 0.001).
Conclusions
The incidence of inaccurate assessment of adequate cuff pressure when determining cuff pressure by pilot balloon palpation was higher in the relatively smaller endotracheal tube size group compared to the larger endotracheal tube size group. Therefore, use of a pressure gauge to confirm adequate pressure is recommended especially when using a smaller tube size.