bluuebunny/crossref_metadata_2025_split huggingface dataset:
BASELINE CHARACTERISTICS, ANTIHYPERTENSIVE EFFECTIVENESS, AND TREATMENT ADHERENCE IN HYPERTENSIVE PATIENTS DEPENDING ON AGE: POST-HOC ANALYSIS OF THE TRICOLOR STUDY
Authors: Logunova Natalia , Karpov Yuri , Khomitskaya Yunona , Kvasnikov Boris 
Published: June 2022

Objective:
To describe baseline (BL) characteristics, changes in systolic (SBP) and diastolic blood pressure (DBP) and in adherence to treatment in patients from TRICOLOR study stratified by age (under 65 years (< 65 y.o.) and 65 years old and older (>= 65 y.o.).

Design and method:
TRICOLOR (NCT03722524) was a multicenter, 3-month, open-label, uncontrolled observational study that included 1 247 uncontrolled hypertensive (HTN) patients in outpatient settings in Russia, in whom perindopril/indapamide/amlodipine single-pill combination (SPC) was initiated in accordance with the Russian label. Treatment adherence was assessed at the final visit (V4) using Girerd’s adherence questionnaire. This post-hoc-analysis is focused on antihypertensive effectiveness, and treatment adherence in HTN patients depending on age.

Results:
Of 1 116 patients included in the analysis, 66.9% (n = 747) were under 65 y.o. and 33.1% (n = 369) were > = 65 y.o. At BL, a higher grade of HTN was observed more often in patients > = 65 y.o. (96.9% vs 88.9%; p < 0.001), they had longer HTN duration (15.11 ± 7,82 vs 8.07 ± 5.31 years; p < 0.001) and more often had HTN-associated comorbidities such as dyslipidemia (73.4% vs 58.5%; p < 0.001), history of coronary artery disease (40.4% vs 17.0%; p < 0.001), prior myocardial infarction or stroke (18.7% vs 8.3%; p < 0.001) comparing to those < 65 y.o.
At V4, in patients treated with the SPC, SBP significantly decreased by 33.5 (95%CI 34.3, 32.7) and 33.2 mmHg (95%CI 34.4, 31.9), DBP by 14.6 (95%CI 15.1, 13.9) and 13.9 mmHg (95%CI 14.8, 12.9), in patients < 65 y.o and > = 65 y.o. respectively, with no significant between group difference. More patients < 65 y.o. achieved target SBP level < 140/90 mmHg at V4 compared to those > = 65 y.o. (96.7% vs 93.6%, respectively; p = 0.027). Proportion of patients adherent to the treatment increased from 54.8% to 95.5% and from 51.2% to.94.0% in both groups, while only 4.6% and 6.0% of patients in these groups remained non-adherent to the treatment.

Conclusions:
Treatment with perindopril/indapamide/amlodipine SPC showed high antihypertensive effectiveness and significantly increased adherence in both age-stratified groups of patients, despite more severe and comorbid conditions observed in patients > = 65 y.o. comparing to those under 65 y.o.
UNATTENDED AUTOMATED OFFICE BLOOD PRESSURE MEASUREMENT VERSUS CLASSIC OFFICE AUTOMATED BLOOD PRESSURE MEASUREMENT IN A HYPERTENSION OUTPATIENT CLINIC
Authors: Légrády Péter , Fejes Imola , Czombos András , Ábrahám György 
Published: June 2022

Objective:
Accurate measurement of blood pressure is a fundamental pre-requisite requirement for an appropriate management of arterial hypertension. In order to eliminate the well-known limitations of classic office blood pressure measurements, the so-called unattended automatic office blood pressure measurement method can be a solution.

Design and method:
In 52 patients arriving for regular follow-up into one of the Hypertension Outpatinet Clinic of the Nephrology-Hypertension Center of the University of Szeged 3–3 blood pressure measurements were made at 1–1 minute intervals first by a doctor with an MIT5 automatic device and then in a separate room unattended, starting alone by the patient with a Hem-907 device. We also included the patients’ home blood pressure in the comparison, which was recorded on the basis of the home diaries they kept.

Results:
Based on our results, the MIT5 device had the highest blood pressure values of the three modalities, both in terms of systolic and diastolic values. The mean systolic blood pressure values measured with MIT5 device were signifincantly higher but not with Hem-907 device compared to home blood pressure values (p = 0.004). Diastolic values measured with MIT5 were significantly higher compared to Hem-907 (p < 0.001) and compared to home measurements (p = 0.001). Forty-nine percent of the patients had blood pressure in the goal range both with MIT5 and Hem-907 device, and 29% with both methods above the goal range. If only one measurement had been taken in each patient during the study, a much higher rate of hypertension would be included in the data.

Conclusions:
Our results support the use of unattended automated office blood pressure measurements in the everyday practice. Whether Hem-907 or other devices should be used is another matter.
ACCURACY AND FEASIBILITY OF SMARTWATCH-BASED CUFFLESS BLOOD PRESSURE MEASUREMENT: A REAL-WORLD PROSPECTIVE OBSERVATIONAL STUDY
Authors: Lee Hae-Young , Han Minju , Lee Young-Ro , Park Taeyoung , Ihm Sang-Hyun , Pyun Wook Bum , Suh Jong-Mo 
Published: June 2022

Objective:
Smartwatch-based blood pressure (BP) measurement will continue to grow in the near future. Recently, BP measurement using a photoplethysmography-based smartphone algorithm paired with a smartwatch is approved as a medical device. We aimed to evaluate the feasibility and measurement stability of the smartphone-based BP measurement.

Design and method:
The Korean Society of Hypertension (KSH) hosted a one-month campaign entitled Daily BP measurement with your Galaxy Watch, and collected the real-world data of smartwatch-based BP measurement. We evaluated the clinical characteristics and blood pressure variability according to measurement timing. Furthermore, we investigated the measurement stability following calibration process.

Results:
We collected 35,646 BP measurement data from 767 participants. Mean age of the participants were 43.72 ± 11.89 years and 80.26% were men. Each participant had an average of 1.50 ± 1.31 BP measurements per day, and 19.74% of the participants measured their BP every day. BP values showed large variability, higher on Monday than those on other days in a week and the lowest from midnight to 4 a.m. highest from noon to 4 p.m., and decreased toward midnight during a day. The degree of measurement error by calibration defined as a BP difference between the measurement values seven days before and after calibration was 6.78 ± 5.58 mmHg. Higher mean BP is the single significant determining factors among age, sex, BP or heart rate in calibration error of the preceding week. The BP values became deviated small but significantly after 17 days of the calibration, with the change was on average 0.02 mmHg/daily.

Conclusions:
Smartwatch-based BP measurement is feasible for BP measurement every day. BP values showed large variability mostly according to measurement hours, then measurement days. The error during the calibration process showed substantial BP fluctuation, warranting meticulous calibration assisted by medical personnel.
OFFICE BLOOD PRESSURE MEASUREMENTS IN HUNGARY: 3 YEAR RESULTS OF AN OPEN LABEL, PROSPECTIVE, OBSERVATIONAL STUDY
Authors: Járai Zoltán , Nemcsik János , Páll Dénes 
Published: June 2022

Objective:
Office blood pressure measurements are used to check the control of blood pressure in treated hypertensive patients. The Hungarian Hypertension Registry which is a noninterventional project of the Hungarian Society of Hypertension, was started in 2018 and will end in 2023.
Our objective was to assess the control rate of hypertension in Hungary and to prove that the increase in the number if routine blood pressure measurement is associated with the higher number of controlled hypertensive subjects.

Design and method:
This is a multicenter, open-label, observational non-interventional study (anonymous data collection), that is performed in GPs’ practices and in outpatient clinics of cardiology and internal medicine. OMRON Medistanceâ service and validated automatic upper arm cuff BP monitors (M3 IT) are used. Data collection are performed directly from the arms of the patients (through Medistanceâ HUB 150 Mobil data procession). All anonymous blood pressure data are directly transferred to the central database.

Results:
3 132 360 blood pressure (BP) measurements were done so far. Before Covid pandemic the average number of daily measurements was 5/day/office, during Covid pandemic this number decreased to 3/day/office. 14.1% of the measurements were in optimal BP range, 14.3 % in normal BP range, 16.0% in elevated-normal range, 31.5% in grade I. hypertension range, 16.8% in grade II. hypertension range and 7.3% in grade III. hypertension range. We observed a substantial seasonal variability in the average BP values: 144.1 mmHg versus 135.7 mmHg and 86.6 versus 82.4 mmHg during wintertime and summertime according to systolic and diastolic blood pressure, respectively.

Conclusions:
The average number of BP measurements in the GPs’ office is low, and during the pandemic it further decreased. The measured BP results indicate, that the majority of the patients are not well-controlled. There is a substantial variability in average BP values between seasons, that has to be accounted during patients’ follow-up.
BLOOD PRESSURE MONITORING IN HEMODIALYSIS PATIENTS: ARE IMPRECISE THE MEASURING PRE- AND POSTDIALYSIS OR INTERDIALYTIC AMBULATORY BP?
Authors: Kasabji Jorge Estifan , Montero Sylvia Sanchez , Rosero Caterin Martinez , Guerrero Xhamy Martelli , Zaldumbide Erica Romero , Alvarez Cristina Lucas , Lopez Arancha Sastre , Giux Elena Monfa , De Leon Gomez Benjamin , Velasco Mario Prieto 
Published: June 2022

Objective:
The optimal Blood Pressure in Hemodialysis are still unclear as to their value or measurement time and better hypotensive treatment.
Some authors recommend BP < 140/90 mmHg and < 130/80 mmHg before and after HD respectively.
There are an associations between predialysis systolic, diastolic and pulse pressure with all-cause mortality.
Our objective is to assess the percentage of hypertensive patients in our hemodialysis unit after adjusting their dry weight and there is a difference between the pre and postdialysis blood pressure measurement.

Design and method:
We included 66 patients(N 66) hemodialysis unit, we have performed standardized BP measurements among hemodialysis patients, predialysis SBP/DBP, postdialysis SBP/DBP, pulse pressure and interdialytic BP assessed by ambulatory.
Patients characteristics: (male [n 36] 54,5%), median age 68 yrs (R 29–90y), DM 25 patients (37,8%),nontraumatic amputation 10 patients (15%).

Results:
Predialysis SBP/DBP values >140/90 mmHg was 50% (33 patients), 51,5% female.
Predialysis Pulse pressure 82 mmHg
Postdialysis SBP/DBP values > 140/90 mmHg was 59% (39 patients), 54% female.
Postdialysis Pulse pressure 83 mmHg
Interdialytic BP value > 140/90 mmHg was 50% (30 patients) and Pulse pressure 78 mmHg
Group HT:DM 17 patients(52%) nontraumatic amputation 8 patients(24%)
Group NO HT:DM 8 patients(24%) nontraumatic amputation 2 patients(6%)
(TABLE 1)

Conclusions:
Until the actuality there is no optimal criteria of BP in hemodialysis patients, or when it should be measured pre or postdialysis.
In our study, we do not see a difference between BP Predialysis, Postdialysis or Interdialytic BP.
Also we see in group HT, there are more diabetics and more nontrauamtic amputation but there is no significant difference between both groups, possibly for being a small sample
REPRODUCIBILITY OF MASKED HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Antza Christina , Farmakis Ioannis , Doundoulakis Ioannis , Akrivos Evangelos , Stalikas Nikolaos , Zafeiropoulos Stefanos , Kostopoulos Georgios , Stabouli Stella , Giannakoulas George , Kotsis Vasilios 
Published: June 2022

Objective:
The aim of this study was to investigate the reproducibility of masked hypertension (MH) either with ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM).

Design and method:
PubMed, Cochrane Library and Web of Science were searched to identify studies with paired baseline office BP and ABPM or HBPM measurements at two timepoints. The outcome of the analysis was the individual phenotype reproducibility between the baseline and follow-up timepoints. The used effect measure was Cohen’s kappa coefficient.

Results:
We found 15 studies eligible for the meta-analysis (5729 patients). The reproducibility of MH was better with ABPM, kappa reliability test: 0.41 (95%CI: 0.32 – 0.49), than with HBPM, kappa reliability test: 0.26 (95%CI: 0.10 – 0.40).

Conclusions:
This systematic review and meta-analysis show a slight to fair reproducibility of MH assessed through HBPM, but better when assessed with ABPM. Considering that poor reproducibility may be a result of office BP measurements, an ABPM/HBPM based strategy should be established for the evaluation and treatment of patients with MH.
THE PERSONAL TRAIT CORRELATED WITH THE NIGHT BLOOD PRESSURE LEVEL IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Andreeva Galiya , Gorbunov Vladimir , Lyusin Dmitriy 
Published: June 2022

Objective:
The aim of our study was to determine associations between the personal trait of patients and the night blood pressure (BP) level in untreated arterial hypertension (AH) patients.

Design and method:
We nalysed database of several studies (200 AH patients without serious concomitant diseases). Ambulatory blood pressure monitoring (ABPM) (Spacelabs 90207) was performed after the washout period (3–7 days). After ABPM each patient completed the Russian version of the psychological questionnaire Minnesota Multiphasis Personality Inventory (MMPI) and the emotional intelligence questionnaire (EmIn, by Lyusin D.) (only 90 patients). We nalysed the following MMPI scales: L – lie scale, F – aggravation scale, K – correction scale, 1 (Hs) – hypochondria, 2 (D) – depression, 3 (Hy) – hysteria, 4 (Pd) – psychopathy, 6 (Pa) – rigidity of affect, 7 (Pt) – psychasthenia, 8 (Sc) – schrizothemia, 9 (Ma) – hypomania. We assessed the following EmIn scale scores: I - emotion self-awareness; II - management of one’s own emotions; III - control of emotional expression; IV - understanding others’ emotions; V- management of others’ emotions. We used Pearson correlation coefficient ®.

Results:
The initial mean ambulatory daytime systolic BP (SBP) was 142.1 ± 14.2, diastolic (DBP) - 89.5 ± 10.1 mm Hg), age - 52,7 ± 12.2 years.(M ± SD). We found the following significant correlations: 1) 9 scale scores of MMPI (optimism, good mood, cheerfulness level) had negative relationships with the night DBP (r = -0,17, p < 0,05) and night SBP (r = -0,16, p < 0,05) levels; 2) IV scale scores of EmIn (understanding others’ emotions) had relations with the night DBP (r = -0,28, p < 0,05) and night SBP (r = -0,30, p < 0,05) levels; 3) V scale scores of EmIn (management of others’ emotions) had correlations with the night DBP (r = -0,26, p < 0,05) and night SBP (r = -0,26, p < 0,05) parameters.
Optimism, cheerfulness, good mood (9 scale scores of MMPI) was associated with the night BP decrease, but intensification of the interpersonal emotional interactions (IV, V scale - management or understanding others’ emotions) can lead to the night BP increase.

Conclusions:
Optimism, cheerfulness, good mood was related with the night BP decrease. But intensification of the interpersonal emotional interactions can lead to the night BP increase.
THE WHITE COAT EFFECT LEVEL CORRELATED WITH LIFESTYLE COMPONENTS AND SOCIO-DEMOGRAPHIC DATA IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Andreeva Galiya , Koshelyaevskaya Yana , Smirnova Marina , Gorbunov Vladimir , Kurekhyan Armine 
Published: June 2022

Objective:
The aim of study was to define if the lifestyle components and socio-demographic data of patients with arterial hypertension (AH) may correlate with white coat effect (WCE) level.

Design and method:
We nalysed ambulatory blood pressure monitoring (ABPM) data of 125 AH patients, who were treated with regular antihypertensive therapy. This study was prospective and included three visits every 3 months: 1 visit - screening, ABPM session; 2 - assessment of the patient’s status and the therapy effectiveness; 3- assessment of the patient’s status, ABPM session (the total ABPM number was 239). The WCE level was assessed as the difference between clinical BP measurement and mean daytime BP. We used ANOVA for statistical analysis.

Results:
The initial mean daytime BP was (M ± SD): systolic (SBP) - 123.2 ± 11.2; diastolic (DBP) - 73.0 ± 6.9 mm Hg. The mean age of the patients was 62.2 ± 8.7. We found relationships between the lifestyle components and WCE: 1) alcohol intake level had negative correlations with systolic WCE (SWCE) (F = -5.7 p < 0.0002) and diastolic WCE (DWCE) (F = -4.0, p < 0.001) levels; 2) smoking intensity had negative correlations with SWCE (F = -4.9 p < 0.001) and DWCE (F = -3.1 p < 0.002). We have identified that age and duration of AH were associated with SWCE (r = 0.23, p < 0.0003 and r = 0.14, p < 0.03 respectively), also height and body mass index (BMI) had negative correlations with DWCE (r = -0.27, p < 0.01) levels. Education level (F = 2.7, p < 0.042 for SWCE and F = 4.7, p < 0.003 for DWCE), marital status (F = 2.4, p < 0.048 for SWCE,) and gender (F = 5.8, p < 0.016 for SWCE and F = 9.2, p < 0.003 for DWCE) were correlated with WCE: WCE was higher in women, widowers and unmarried persons without higher education (see table).

Conclusions:
Thus, increase of the alcohol intake and smoking intensity can lead to WCE reduction and the masked hypertension manifestation. Height and body mass index had negative correlations with WCE, age and duration of AH had positive association with WCE. Also, WCE was higher in women, widowers and unmarried persons without higher education. Probably, married young tall men with higher education have a tendency to the masked hypertension manifestation.
CIRCADIAN PATTERN IN PATIENTS OLDER THAN 75 YEARS WITH HYPERTENSION
Authors: Carbonell Ana M. Piera , Anton Pilar Rodriguez , Carrasco Rodrigo Orellana , Suarez M. Jesus Campomanes , Robert M. Ángeles Gavaldá , Lozano Juan Eugenio Forcada , Diaz Miguel Ángel Prieto , Sanchez Vicente Martin , Rodríguez Ángel Díaz , Garrote Juan Antonio Divison , Carratalá Vicente Pallarés 
Published: June 2022

Objective:
To know the circadian pattern of hypertensive patients older than 75 years, by monitoring blood pressure for 24 hours.

Design and method:
Multicenter cross-sectional descriptive study in hypertensive patients aged 75 or over. It was designed for a sample of 117 people, calculated for 8% hypotensive episodes, with a 95% confidence interval, 5% precision, and 25% losses.
Non-proportional stratified random sampling was performed, excluding patients with modified antihypertensive treatment in the last month and/or arrhythmias.
Through 24-hour ambulatory blood pressure monitoring, the incidence of hypotensive episodes was observed.
Associated comorbidities, antihypertensive treatment, and sleep quality during ABPM were recorded from the interview and clinical history.
Percentages, means, confidence intervals were obtained and the chi square test was performed in the bivariate analysis.

Results:
Of 117 monitored patients, 100 completed the study, with a mean age of 79.2 years (SD 3.9 years) and 59% women. 91.5% of women and 58.6% of men were overweight or obese. Some type of heart disease was associated with 31% of patients, and 33% had DM2, 38% anxiety-depressive disorder, and vertigo, 16%. 50.8% of the women and 61% of the men did not have good control of the mean TAS figures in the 24-h ABPM. However, DBP was controlled in 84.7% and 80.5% of women and men, respectively. The mean BP was 145.49/78.9 (SD 21 and 11.7, respectively). 34% of the patients presented a dipper pattern. 27% have a riser pattern. 76% of the patients presented at least one episode of hypotension, which was accompanied by symptoms in 11.8% of the cases, with headache and dizziness being the most frequent. No significant association has been observed between the number of antihypertensive drugs and the occurrence of hypotensive episodes.

Conclusions:
Most of the patients presented an alteration in the circadian pattern of blood pressure in ABPM and poor control of BP figures, especially at the expense of systolic blood pressure. It is advisable to monitor blood pressure in the elderly to adapt control to chronotherapy criteria.
IS HOME BLOOD PRESSURE SELF MONITORING HERE TO STAY? AN EVALUATION OF PATIENT SATISFACTION WITH HOME BLOOD PRESSURE MONITORING IN A RURAL POPULATION DURING THE COVID PANDEMIC
Authors: Patel Anjali , Rasheed Reshma , Zarif Ahmad , Mahmod Azad , Bibi Hajira , Nazir Imad 
Published: June 2022

Objective:
During the COVID pandemic patients with hypertension were trained to self-monitor blood pressures at home. A post service transformation evaluation was undertaken as COVID restrictions were eased to assess if patients would prefer office blood pressure vs home monitoring for ongoing care.

Design and method:
A retrospective analysis of all patients who consented to home blood monitoring during the COVID pandemic was undertaken at 12 months across three health centre in a rural population. Patients were asked of their perception of doing home blood pressure readings and their confidence and satisfaction with this method vs office.
Method: Patients were asked during routine medication reviews and at the end of 12 months of their confidence and satisfaction and difficulties with managing home blood pressure monitoring in order to understand their preferences for future care

Results:
Of the total of over 2000 patients with known diagnosis of hypertension n = 2000, a sample cohort of 500 patients (sample size 25%) were asked as they had medication reviews of their confidence with the self-monitoring. The no of patients who felt confident and wished to continue was quite high 70% this did not vary across the ages i.e. both young and the elderly were content doing their own home blood readings. Only 50 patients (11.8%) wanted office readings reasons were affordability and lack of confidence with the reliability of home readings and those who were very elderly wanted the human contact which they previously had.

Conclusions:
Home blood pressure self-monitoring is a safe reliable and evidenced based and previously underutilized method of monitoring patients with hypertension. We believe the office readings of blood pressure still have a place in routine care but the overwhelming response and satisfaction with home blood pressure is likely to change monitoring and lead to better overall blood pressure control.