bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Honey in Obesity Management: A Systematic Review
Authors: Ugusman Azizah , Shahrin Syarifah Amirah Syed , Azizan Nurul Hana , Pillai Siva Balan , Krishnan Khamini , Salamt Norizam , Aminuddin Amilia , Hamid Adila A. , Kumar Jaya , Mokhtar Mohd Helmy 
Published: June 2022

Obesity is a metabolic disorder that has become critically prevalent throughout the world. Obesity has been linked to other chronic diseases such as diabetes mellitus, cardiovascular diseases and cancer. Natural products such as honey have been investigated for their potential effect on obesity. Hence, this study systematically reviewed the recent literature concerning the effects of honey on obesity in obese animal models and in people with obesity. The Ovid MEDLINE, PubMed, Scopus, Web of Science and Google Scholar electronic databases were searched for relevant articles. A total of 130 relevant articles were obtained from the initial search. Following a thorough screening, nine articles were selected for data extraction, including six animal studies and three clinical trials. In most of the animal studies, honey demonstrated an anti-obesity effect by reducing body weight, body fat composition and adipocyte size, among others. However, supplementation of honey in clinical trials showed conflicting results. Even though honey supplementation did not demonstrate any weight-reducing effect in some of the clinical trials, none of the trials showed that honey increases body weight. However, the results should be interpreted with caution as most of the studies involved animal models and there is a limited number of high quality, randomized, controlled clinical trials.Systematic Review Registrationhttps://inplasy.com/inplasy-2022-6-0038/ PROSPERO, identifier 10.37766/inplasy2022.6.0038.
Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations
Authors: Ondroušková Eva , Bohúnová Michaela , Závacká Kristýna , Čech Patrik , Šmuhařová Petra , Boudný Miroslav , Oršulová Martina , Panovská Anna , Radová Lenka , Doubek Michael , Plevová Karla , Jarošová Marie 
Published: June 2022

Chronic lymphocytic leukemia (CLL) with cytogenetics findings, such as complex karyotype and deletions of TP53 or ATM, is associated with adverse clinical outcomes. Additional chromosomal abnormalities further stratify patients into groups with diverse prognoses. Gain of 8q24 is one of the abnormalities considered as prognostically unfavorable. In our study, we performed a FISH analysis in an initial cohort of 303 consecutive CLL patients and determined the frequency of +8q to be 6.3 %. Our analysis confirmed the association with TP53/ATM aberrations and CK, as the frequency of +8q reached 26.7 % in an extended delTP53/ATM+CK cohort. M-FISH analysis enabled the identification of partner chromosomes where the segment of the duplicated 8q arm was localized. More detailed mapping of the gained 8q region using the M-BAND method determined the smallest amplified region 8q23-8qter. We observed significantly shorter overall survival (OS; 9.0 years in +8q-positive vs. 10.6 years in +8q-negative; p=0.02) and detected slightly higher MYC mRNA/protein levels in +8q-positive vs. +8q-negative patients.
Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder
Authors: Chen Rucheng , Zhang Jinna , Pang Yaxian , Liu Qingping , Peng Jing , Lin Xiujuan , Cao Lingyong , Gu Weijia , Zhang Lu , Li Ran , Sun Qinghua , Zhang Rong , Liu Cuiqing 
Published: June 2022

Fine particulate matter (PM2.5) is well known to impair lung function. Strategies protecting against PM2.5-exerted lung dysfunction have been less investigated. Qianjinweijing decoction (QJWJ), a decoction of a herbal medicine of natural origin, has been used to treat lung disorders as it inhibits oxidation and inflammation. However, no clinical trial has yet evaluated the role of QJWJ in PM2.5-induced lung dysfunction. Therefore, we conducted a randomized, double-blind, placebo-controlled trial to assess whether QJWJ provided lung benefits against the adverse effects of PM2.5 exposure among adults. Eligible participants (n = 65) were recruited and randomized to receive QJWJ decoction (n = 32) or placebo (n = 33) for 4 weeks. The restrictive ventilatory defect (RVD), lung function parameters, and induced sputum were analyzed. The PM2.5 exposure concentration was significantly associated with the vital capacity (VC), peak expiratory flow (PEF), and forced expiratory flow at 75% of the forced vital capacity (FEF75). The negative associations between PM2.5 and the lung function parameters were eliminated in response to the QJWJ intervention. Additionally, the percentage of RVD (P = 0.018) and the proportion of eosinophils (Eo%) in induced sputum (P = 0.014) in the QJWJ group was significantly lower than that in the placebo group. This study demonstrated that QJWJ could alleviated PM2.5-induced lung dysfunction and could be a potential treatment for air pollution-related chronic respiratory disease.
Treatment Strategy in Atrial Tachycardia Originating From the Atrial Appendage
Authors: Hai-Yang Xie , Zi-Cong Feng , Xiao-Gang Guo , Qi Sun , Jian-Du Yang , Jian Ma 
Published: June 2022

Background: Atrial appendage tachycardia (AAT) originating from the atrial appendage (AA) is extremely difficult to eliminate using radiofrequency catheter ablation (RFCA). The optimal management strategy for AAT refractory to RFCA remains unclear.Objective: This study aims to investigate the long-term result of ablative therapy and the optimal alternative management for AAT refractory to RFCA.Methods: A total of 51 patients with AAT originating from the AA undergoing RFCA were recruited. Video-assisted atrial appendectomy and oral ivabradine were performed on those with AATs refractory to RFCA, and this study aimed to evaluate their safety and long-term efficacy.Results: We included 51 patients (51/586, 8.7%) with AATs confirmed by activation mapping and contrast venography. Among them, there were 28 (54.9%) AATs originating from the distal AA. In total, 14 (27.4%) AATs were refractory to RFCA, including 13 originating from the distal AA and one arising from the proximal AA. Ten of 11 (90.9%) AATs originating from the distal AA were eliminated after an atrial appendectomy, and the other three AATs were suppressed using oral ivabradine. Origins from the distal AA refractory to RFCA and early age of AAT onset ≤26.5 years indicated the need for atrial appendectomy. No major complications occurred, and nine patients with tachycardia-induced cardiomyopathy fully recovered. Long-term success was achieved in 98.0% of patients with multiple treatment managements.Conclusion: AATs originating from the distal AA were more refractory to RFCA. RFCA was the cornerstone of AAT catheter ablation. Video-assisted thoracoscopic atrial appendectomy was an effective strategy for those origins at the distal AA and the age of AAT onset ≤26.5 years. Ivabradine represents a promising treatment for AAT temporarily in pediatric and young adult patients.
Identification of Hub Genes and Immune-Related Pathways for Membranous Nephropathy by Bioinformatics Analysis
Authors: Cai Xiao-Yu , Wang Zu-Feng , Ge Shu-Wang , Xu Gang 
Published: June 2022

OBJECTIVE: We aim to explore the detailed molecular mechanisms of membrane nephropathy (MN) related genes by bioinformatics analysis.METHODS: Two microarray datasets (GSE108109 and GSE104948) with glomerular gene expression data from 65 MN patients and 9 healthy donors were obtained from the Gene Expression Omnibus (GEO) database. After processing the raw data, DEGs screening was conducted using the LIMMA (linear model for microarray data) package and Gene set enrichment analysis (GSEA) was performed with GSEA software (v. 3.0), followed by gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The protein-protein interaction (PPI) network analysis was carried out to determine the hub genes, by applying the maximal clique centrality (MCC) method, which was visualized by Cytoscape. Finally, utilizing the Nephroseq v5 online platform, we analyzed subgroups associated with hub genes. The findings were further validated by immunohistochemistry (IHC) staining in renal tissues from MN or control patients.RESULTS: A sum of 370 DEGs (188 up-regulated genes, 182 down-regulated genes) and 20 hub genes were ascertained. GO and KEGG enrichment analysis demonstrated that DEGs of MN were preponderantly associated with cell damage and complement cascade-related immune responses. Combined with literature data and hub gene-related MN subset analysis, CTSS, ITGB2, and HCK may play important roles in the pathological process of MN.CONCLUSION: This study identified novel hub genes in MN using bioinformatics. We found that some hub genes such as CTSS, ITGB2, and HCK might contribute to MN immunopathological process, providing new insights for further study of the molecular mechanisms underlying glomerular injury of MN.
Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder
Authors: Yang Ruchang , Du Xiangdong , Li Zhe , Zhao Xueli , Lyu Xiaoli , Ye Gang , Lu Xinchuan , Zhang Guangya , Li Chuanwei , Yue Yan , Wu Yuxuan , Peng Ruijie , Zhou Yue , Wang Haitao , Wu Siqi , Ganapathi Pallavi B. , Wu Hanjing Emily , Zhang Xiangyang 
Published: June 2022

BackgroundsSubclinical hypothyroidism (SCH) was reported to be associated with depression; however, its role in coexisting anxiety symptom in young patients with major depressive disorder (MDD) remains unclear. The objective of this study was to explore the relationship between SCH and anxiety symptom in young first-episode and drug-naïve (FEDN) MDD patients.MethodsA total of 520 outpatients diagnosed as FEDN MDD with SCH were recruited in this study. Their socio-demographic, clinical data and thyroid function parameters were collected. The Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD) were employed to measure the severity of anxiety symptom and depressive symptom, respectively. Based on the HAMA scores, patients who scored ≥ 25 were defined as anxious major depressive disorder (A-MDD) while others as non-anxious major depressive disorder (NA-MDD).ResultsThe prevalence rate of A-MDD was 15.8% in young FEDN MDD patients with comorbid SCH. Moreover, serum thyroid stimulating hormone (TSH) levels were significantly higher in patients with A-MDD compared with those with NA-MDD (p &lt; 0.001). Multivariate binary logistic regression analysis indicated that A-MDD was associated with serum TSH levels with an odds ratio (OR) of 1.602. Serum TSH level of 6.17 mIU/L was the critical value to distinguish A-MDD and NA-MDD, with sensitivity of 0.805 and specificity of 0.539. There were no statistically significant differences between NA-MDD and A-MDD patients in terms of socio-demographic variables, serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidases antibody (TPOAb) and anti-thyroglobulin (TgAb) levels.ConclusionsA-MDD patients presented higher serum TSH level. It is suggested that serum TSH level may be a potential biomarker for predicting moderate and severe anxiety symptoms in young FEDN MDD patients with SCH.
Systematic Review and Meta-Analysis of Vortioxetine for the Treatment of Major Depressive Disorder in Adults
Authors: Zhang Xinyan , Cai Yuchun , Hu Xiaowen , Lu Christine Y. , Nie Xiaoyan , Shi Luwen 
Published: June 2022

ObjectiveWe aimed to compare the efficacy, acceptability, and tolerability of vortioxetine in the treatment of Major Depressive Disorder (MDD) in adults.MethodWe searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Clinical Trials (CENTRAL), and www.ClinicalTrials.gov for randomized controlled trials that examined vortioxetine vs. placebo or other antidepressants for the treatment of MDD from database inception to August 30, 2021, using keywords Vortioxetine, Brintellix, Trintellix, LuAA21004, major depressive disorder, mood disorder, affective disorder, and MDD. We identified 789 publications after removing duplicates. After screening, 20 eligible randomized controlled trials were identified, of which 19 were included in the final meta-analysis. We included adults (aged 18 years and older) with a primary diagnosis of MDD. Two review authors independently selected the studies and extracted data. We extracted data on study characteristics, participant characteristics, intervention details and outcome measures in terms of efficacy, acceptability, and tolerability. Analyses were performed using random-effects models, and outcomes were pooled as risk ratios (RRs) and standardized mean differences (SMDs).ResultsIn total, 20 studies (8,547 participants) met the inclusion criteria. Vortioxetine outperformed the placebo in efficacy outcomes, including response (RR 1.35, 95% CI 1.23–1.48; P &lt; 0.001), remission (RR 1.33, 95% CI 1.17–1.52; P &lt; 0.001), and cognitive function (SMD 0.34, 95% CI 0.16–0.52; P = 0.0003). Compared with the serotonin noradrenaline reuptake inhibitors (SNRIs), vortioxetine had better tolerability (RR 0.90, 95% CI 0.86–0.94; P &lt; 0.001) but no significant difference in response (RR 0.91, 95%CI 0.82–1.00; P = 0.06) or remission (RR: 0.99, 95% CI 0.81–1.20, P = 0.88). Vortioxetine had no difference in response (RR 1.08, 95% CI 0.88–1.32; P = 0.46), remission (RR 1.00, 95% CI 0.41–2.44; P = 1.00) comparing with selective serotonin reuptake inhibitors (SSRIs).ConclusionsVortioxetine is more advantageous over placebo in treating MDD among adults, but no significant difference compared to SNRIs and SSRIs in general.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42021278355, identifier: CRD42021278355.
Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction
Authors: Dang Jinghan , Tao Qiuying , Niu Xiaoyu , Zhang Mengzhe , Gao Xinyu , Yang Zhengui , Yu Miaomiao , Wang Weijian , Han Shaoqiang , Cheng Jingliang , Zhang Yong 
Published: June 2022

BackgroundPrevious voxel-based morphometric (VBM) and functional magnetic resonance imaging (fMRI) studies have shown changes in brain structure and function in cocaine addiction (CD) patients compared to healthy controls (HC). However, the results of these studies are poorly reproducible, and it is unclear whether there are common and specific neuroimaging changes. This meta-analysis study aimed to identify structural, functional, and multimodal abnormalities in CD patients.MethodsThe PubMed database was searched for VBM and task-state fMRI studies performed in CD patients between January 1, 2010, and December 31, 2021, using the SEED-BASE d MAP software package to perform two independent meta-groups of functional neural activation and gray matter volume, respectively. Analysis, followed by multimodal analysis to uncover structural, functional, and multimodal abnormalities between CD and HC.ResultsThe meta-analysis included 14 CD fMRI studies (400 CD patients and 387 HCs) and 11 CD VBM studies (368 CD patients and 387 controls). Structurally, VBM analysis revealed significantly lower gray matter volumes in the right superior temporal gyrus, right insula, and right retrocentral gyrus than in the HC. On the other hand, the right inferior parietal gyrus increased in gray matter (GM) volume in CD patients. Functionally, fMRI analysis revealed activation in the right temporal pole, right insula, and right parahippocampal gyrus. In the right inferior parietal gyrus, the left inferior parietal gyrus, the left middle occipital gyrus, and the right middle frontal gyrus, the degree of activation was lower.ConclusionThis meta-analysis showed that CD patients had significant brain GM and neural changes compared with normal controls. Furthermore, multi-domain assessments capture different aspects of neuronal alterations in CD, which may help develop effective interventions for specific functions.
Direct Medical Costs of Tetanus, Dengue, and Sepsis Patients in an Intensive Care Unit in Vietnam
Authors: Hung Trinh Manh , Van Hao Nguyen , Yen Lam Minh , McBride Angela , Dat Vu Quoc , van Doorn H. Rogier , Loan Huynh Thi , Phong Nguyen Thanh , Llewelyn Martin J. , Nadjm Behzad , Yacoub Sophie , Thwaites C. Louise , Ahmed Sayem , Van Vinh Chau Nguyen , Turner Hugo C. ,   The Vietnam ICU Translational Applications Laboratory (VITAL) Investigators
Published: June 2022

BackgroundCritically ill patients often require complex clinical care by highly trained staff within a specialized intensive care unit (ICU) with advanced equipment. There are currently limited data on the costs of critical care in low-and middle-income countries (LMICs). This study aims to investigate the direct-medical costs of key infectious disease (tetanus, sepsis, and dengue) patients admitted to ICU in a hospital in Ho Chi Minh City (HCMC), Vietnam, and explores how the costs and cost drivers can vary between the different diseases.MethodsWe calculated the direct medical costs for patients requiring critical care for tetanus, dengue and sepsis. Costing data (stratified into different cost categories) were extracted from the bills of patients hospitalized to the adult ICU with a dengue, sepsis and tetanus diagnosis that were enrolled in three studies conducted at the Hospital for Tropical Diseases in HCMC from January 2017 to December 2019. The costs were considered from the health sector perspective. The total sample size in this study was 342 patients.ResultsICU care was associated with significant direct medical costs. For patients that did not require mechanical ventilation, the median total ICU cost per patient varied between US$64.40 and US$675 for the different diseases. The costs were higher for patients that required mechanical ventilation, with the median total ICU cost per patient for the different diseases varying between US$2,590 and US$4,250. The main cost drivers varied according to disease and associated severity.ConclusionThis study demonstrates the notable cost of ICU care in Vietnam and in similar LMIC settings. Future studies are needed to further evaluate the costs and economic burden incurred by ICU patients. The data also highlight the importance of evaluating novel critical care interventions that could reduce the costs of ICU care.
Effect of Window and Hole Pattern Cut-Outs on Design Optimization of 3D Printed Braces
Authors: Rizza Robert , Liu XueCheng , Anewenter Vince 
Published: June 2022

BackgroundThere are many different Thoracic Lumbar Sacral Orthosis style brace designs available in the market for the correction of scoliosis deformity. Hole cut out patterns, are commonly used in brace designs. These cut-outs may be subdivided into two groups: hole patterns and windows. Hole patterns are an array of holes which are implemented to lighten the weight of a brace and allow for the skin to breathe. Windows provide space for spinal derotation and/or breathing. From an examination of the literature, it appears that a systematic analysis of the effect of these cut-outs on the structural integrity and functionality of the brace has not been undertaken. Furthermore, there is a lack of understanding on the effect of spacing, size and geometry of the cut-outs on the mechanical behavior of the brace.Method of ApproachIn this study, Finite Element Analysis is employed to examine the mechanical response of the brace to these cut-outs. Geometry for the Thoracic Lumbar Sacral Orthosis was obtained by scanning an existing brace using an optical scan and converted into a Computer Aided Design model. A systematic approach was undertaken where cut-out geometry, spacing and size was varied. The deformation and stress in the thickness of the brace was ascertained from the Finite Element Analysis. An appropriate factor of safety for the structural analysis was determined using a standardized approach and used to quantify the structural integrity of the brace due to the cut-out. Various geometries were analyzed for the hole patterns including circle, triangle, diamond, and hexagon. For the window, the geometries considered were circle, trapezoidal and the “bib” geometry.ResultsIt was found that linear hole patterns where the holes are aligned do not provide a desirable structural factor safety. Furthermore, among all the possible geometries, the hexagonal cut-out was the best structurally while reducing the weight of the brace the most. The optimal spacing was found to be 12 mm, and the optimal hole surface area was found to be 78.54 mm2. For the windows in the abdominal area, the “bib” shape provided the best structural integrity and generated the lowest amount of deformation. An increase in the size of this window had a small effect on the stress but an almost negligible effect on the deformation.ConclusionsA hexagonal hole pattern should be used with a spacing of 12 mm and each hole should have a surface area of 78.54 mm2. Windows in the abdominal area should be of “bib” shape. The size of the window cut-outs does not affect the brace stress and deformation significantly. Thus, the size of these windows should be based on the functional aspects of the brace, i.e., the minimum required size needed to permit the patient to breathe comfortably as in the case of the abdominal window or to allow for proper derotation, as in the case of the derotation window.
Stock Prices Analysis and Forecasting
Authors: albaroudi Elham 
Published: June 2022

<p> Stock Expectation plays a crucial part in fund and financial matters. Numerous individuals contribute billions of monetary standards on the stocks anticipating the benefit after every single stock is obtained. Depending on the behavior of advertising there are ups and downs within the benefit, so the issue of quick and exact estimating of share cost becomes vital. Such a prediction may be enhanced by using Machine and Deep Learning, and this dissertation proposes a novel strategy for predicting stock cost, oil, and gold forecast based on profound learning and outfit learning strategies. Therefore, this dissertation assesses and describes the following two types of frequently used models: Economic Factors in Standard Time Series based on various approaches and features. Previous studies attempted to forecast future gold and prices using previous data and Structural Models which attempt to explain the links between oil and gold prices about a range of economic considerations using machine learning models: SVM, Random Forest, Linear Regression, Random Forest Regression, and LSTM. These predictions are based on the sliding window technique and try to implement such a system and apply it for forecasting using oil and gold time series. By using Machine and Deep Learning methods, more accurate forecasting in stock prices may be obtained and this dissertation sought to answer the following questions about this general premise: What is the effect of the major oil and company financial results on future price? What is the effect between oil and price and how that will affect the gold future price? What is the coloration between US prices and the stock market? How will natural disasters, disease, and wars affect oil, and gold prices? The accompanying macroeconomic variables were utilized which are S&P 500 List, New York Stock Trade List (NYSE), and US Dollar List and Consumer Feeling Record (CSI). Findings that NYSE is affected a positive strong correlation on oil price while oil price affects positive strong correlation on the gold price. Also, USD affects a strong negative correlation with the stock market (oil and gold). Finally, by analyzing the increase and decrease in oil prices from OPEC, an indirect relationship was discovered. </p>