bluuebunny/crossref_metadata_2025_split huggingface dataset:
Echocardiographic assessment of cardiovascular function and clinical outcomes in liver transplant recipients
Authors: Lim Wen Hui , Chew Nicholas WS , Quek Jingxuan , Ng Cheng Han , Tan Darren Jun Hao , Xiao Jieling , Nah Benjamin , Lee Guan Huei , Huang Daniel Q. , Tan Eunice Xiang Xuan , Muthiah Mark D. 
Published: August 2022

AbstractBackground & AimsCardiovascular disease contributes to a high rate of morbidity and mortality after liver transplantation (LT). However, the progression of cardiac function and cardiac remodeling in LT recipients remains poorly understood. This study sought to evaluate the progression of cardiac function and structure in LT recipients and identify independent predictors of prognosis using echocardiography.MethodsFrom 2009 to 2019, 178 adult LT recipients at a tertiary academic transplant center were retrospectively studied. Transthoracic echocardiograms 1‐year pre‐ and post‐LT were assessed. Primary outcomes were progression of systolic and diastolic function. Secondary outcomes included left ventricular remodeling, all‐cause mortality, and heart failure readmission post‐LT. Subgroup analyzes were performed for etiology of native liver disease. A multivariable model was constructed to examine independent predictors of outcomes.ResultsSystolic function significantly worsened, with reduction in stroke volume (45–37 ml/m2,p < .001), left ventricular ejection fraction (LVEF) (65%–62%,p < .001) and cardiac index (3.00–2.60 L/min/m2,p < .001). Conversely, there were significant improvements in diastolic indices, including tricuspid regurgitation Vmax(228–215 cm/s,p = .017), left atrial volume index (LAVI) (32–26 ml/m2,p < .001) and right ventricular systolic pressure (RVSP) (31–28 mmHg,p = .001). Additionally, patients had increased relative wall thickness (RWT) (p < .001) and decreased left ventricular end‐diastolic dimension/body surface area (p < .001) post‐LT. The independent predictors for all‐cause mortality and heart failure were increased pre‐LT mitral annular early diastolic velocity (HR 1.11, CI 1.02–1.22,p = .018), LAVI (HR 1.06, CI 1.02–1.11,p = .007) and decreased LVEF (HR .89, CI .82–.97,p = .006). The effect of non‐alcoholic steatohepatitis on cardiovascular outcomes post‐LT was largely comparable to that of Hepatitis B.ConclusionThis study showed reduced systolic and improved diastolic function in LT recipients and highlighted the utility of pre‐LT echocardiogram in the prognostication and risk stratification of LT candidates.
Prevalence and risk factors of cognitive frailty in community‐dwelling older adults with diabetes: A systematic review and meta‐analysis
Authors: Lyu Qiong , Guan Chi‐Xun , Kong Ling‐Na , Zhu Jia‐Lu 
Published: August 2022

AbstractAimsCognitive frailty can increase the risk of adverse health outcomes in older adults. Estimates of the prevalence of cognitive frailty among older adults with diabetes varied widely in literature. This study aimed to conduct a systematic review and meta‐analysis to assess the pooled prevalence of cognitive frailty and risk factors in community‐dwelling older adults with diabetes, providing evidence for healthcare professionals to better understand the status of cognitive frailty and help develop effective interventions.MethodsDatabases of PubMed, Web of Science, Cochrane Library, Embase, Cumulative Index of Nursing and Allied Health, Proquest, China National Knowledge Infrastructure and China Biology Medicine were searched from inception to February 10th, 2022. The reviewers independently selected studies, extracted data and assessed the quality of studies. Pooled prevalence of cognitive frailty and risk factors were estimated. Subgroup analysis, meta‐regression analysis, sensitivity analysis and publication bias were also conducted.ResultsA total of 15 studies with 6391 participants were included in this review. The pooled prevalence of cognitive frailty was 11% (95%CI = 7.9–14%) in community‐dwelling older adults with diabetes. Pooled estimates showed that increasing age, higher level of HbA1c, shorter night sleep duration and depression were risk factors, and regular exercise was the protective factor of cognitive frailty in community‐dwelling older adults with diabetes.ConclusionCognitive frailty was common in community‐dwelling older adults with diabetes. Routine screening of cognitive frailty and effective interventions should be implemented for this population in community settings.RegistrationPROSPERO ID CRD42021276973.
Stratigraphic reconstruction of the lower–middle Miocene Goto Group, Nagasaki Prefecture, Japan
Authors: Kiyokawa Shoichi , Yasunaga Masaru , Hasegawa Takanori , Yamamoto Ayako , Kaneko Daisaku , Ikebata Yuta , Hasebe Noriko , Tsutsumi Yukiyasu , Takehara Mami , Horie Kenji 
Published: August 2022

AbstractThe Goto Islands are located at the westernmost tip of the Japan archipelago, and preserve a lower–middle Miocene sedimentary sequence deposited during rifting of the continental margin and opening of the Sea of Japan. The stratigraphy of the Goto Group and new K–Ar, fission‐track, and U–Pb age data were used to determine the initial conditions of rifting in southwest Japan. The thickness of the Goto Group is 2000–3000 m. The lower unit (ca. 22–17.6 Ma) consists of thick, greenish, volcaniclastic rocks with basaltic volcanic material, representing the initial stages of continental rifting. The middle unit (ca. −17.6 Ma) consists of alternating sandstones and shales deposited in lacustrine and meandering fluvial environments in a syn‐rift sedimentary basin during a period of volcanic activity. The upper unit (ca. 17.6–16.8 Ma) consists of thick sandstones of fluvial–deltaic facies that were deposited during rapid subsidence at the continental margin. This unit was deposited by a large fluvial system that flowed into the Sea of Japan. These sequences contain relatively cooler to warmer flora (Daijima‐type) and record the warm period of the Miocene Climatic Optimum. The Goto felsic volcanic rocks (16.8 ~ 15.4 Ma) unconformably overlie the Goto Group, and granitic magmatism (ca. 16–14.5 Ma) occurred after sedimentation of the Goto Group. The widespread lacustrine, meandering–braided fluvial, and vast deltaic systems of the Goto Group, and felsic volcanism, were formed due to rapid subsidence that produced a horst‐and‐graben basin during the early stages of rifting of a volcanic arc along the eastern margin of Eurasia. These events occurred from 22.0 to 16.8 Ma before and during the formation of the Sea of Japan.
Cryptic genetic divergence of the red dwarf rasbora,Microrasbora rubescens, in and around Inle Lake: implications for the origin of endemicity in the ancient lake in Myanmar
Authors: Fuke Yusuke , Kano Yuichi , Tun Sein , Yun LKC , Win Seint Seint , Watanabe Katsutoshi 
Published: August 2022

AbstractInle Lake, an ancient lake located in the Shan Plateau of Myanmar, is a biogeographically attractive region with high fish endemism. Some endemic species inhabit the lake as well as the surrounding areas. The genetic and ecological relationships between populations in the lake and surrounding areas provide important insights into the process underlying ichthyofaunal formation in Inle Lake. In this study, the authors focused on red dwarf rasboraMicrorasbora rubescens, an endemic genus and species in this region, and estimated its population structure and evolutionary scenario based on genome‐wide polymorphism, mtDNA and geometric morphometric analyses using samples from Inle Lake and three areas surrounding the lake. The results showed thatM. rubescenscomprises at least three genetically divergent lineages (Inle, Heho and Hopong) with distinct geographic structures consistent with nuclear and mtDNA data. In contrast, there was no clear regional differentiation in morphology. The divergence time estimation based on mtDNA suggests that the Hopong lineage diverged at 2.7 Ma and the Inle and Heho lineages diverged at 1.9 Ma – consistent with the nuclear DNA results. The deep divergence observed in the endemic species supports the ancient history of ichthyofaunal development in this region. The distinct regional differentiation and morphological conservatism of this species might have been shaped by niche conservatism in stagnant water environments that limit dispersal and morphological diversification. Future comprehensive genetic and morphological analyses and comparisons for other native species should reveal the geographic and ecological processes that shaped the ichthyofauna in this region.
Further spread of perch rhabdovirus on European percid farms
Authors: Pallandre Laurane , Schmidt‐Posthaus Heike , Pozet Françoise , Rupp Mélanie , Cristina Elodie , Bigarré Laurent 
Published: August 2022

AbstractVariants of perch rhabdovirus (PRV) circulate across European percid farms via the fish trade. To trace their circulation, they are usually isolated by cell culture and subsequently identified genetically by sequencing partial or complete genes. Here, a newly developed nested PCR‐based method was used to amplify and sequence the complete N and P genes directly from clinical samples obtained during an outbreak on a farm as well as from four batches of fish sampled from two other farms in another country. In an attempt to trace the origin of the five detected viruses, their N and P sequences were concatenated and compared with related viruses. One virus found in pike‐perch was highly related to a virus isolated in 2016 in Belgium. Two other viruses detected on a single farm were distinct from one another, with one being almost identical to another virus isolated in 2016 in Belgium and the other being more closely related to a subgroup with different origins, France and Belgium. Two other viruses found in perch from a third farm were identical and were more related to a subgroup of viruses isolated in France. Identifying variants by a direct PCR approach will help to prevent further dissemination in farms.
A Mediterranean and low‐fat dietary intervention in non‐alcoholic fatty liver disease patients: Exploring participant experience and perceptions about dietary change
Authors: George Elena S. , Forsyth Adrienne K. , Reddy Anjana , Itsiopoulos Catherine , Roberts Stuart K. , Nicoll Amanda J. , Ryan Marno C. , Tierney Audrey C. 
Published: August 2022

AbstractBackgroundA Mediterranean diet (MD) appears to be beneficial in non‐alcoholic fatty liver disease (NAFLD) patients in Mediterranean countries; however, the acceptability of a MD in non‐Mediterranean populations has not been thoroughly explored. The present study aimed to explore the acceptability through understanding the barriers and enablers of the MD and low‐fat diet (LFD) interventions as perceived by participating Australian adults from multicultural backgrounds with NAFLD.MethodsSemi‐structured telephone interviews were performed with 23 NAFLD trial participants at the end of a 12‐week dietary intervention in a multicentre, parallel, randomised clinical trial. Data were analysed using thematic analysis.ResultsParticipants reported that they enjoyed taking part in the MD and LFD interventions and perceived that they had positive health benefits from their participation. Compared with the LFD, the MD group placed greater emphasis on enjoyment and intention to maintain dietary changes. Novelty, convenience and the ability to swap food/meals were key enablers for the successful implementation for both of the dietary interventions. Flavour and enjoyment of food, expressed more prominently by MD intervention participants, were fundamental components of the diets with regard to reported adherence and intention to maintain dietary change.ConclusionsParticipants randomised to the MD reported greater acceptability of the diet than those randomised to the LFD, predominantly related to perceived novelty and palatability of the diet.
Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages
Authors: Starace Michela , Granger Corinne , Carpanese Miriam Anna , Alessandrini Aurora , Bruni Francesca , Piraccini Bianca Maria 
Published: August 2022

AbstractObjectivesThe objective of our study is the review of the literature on the efficacy and safety of a novel water‐soluble nail strengthened (WSNS) containing hyaluronic acid and Pistacia lentiscus used for the improvement of nail plate diseases.Materials and MethodsWe conducted literature research on PubMed/MEDLINE to identify all the studies reporting the use of hyaluronic acid and P. lentiscus in the improvements of nail alterations.ResultsWe found two reports and two posters published in the literature, accounting for 96 patients treated with WSNS containing P. lentiscus and hyaluronic acid. The 83 patients were affected by brittle nails and 13 patients by onychomycosis.ConclusionsThis review demonstrates that the daily application of this new product containing P. lentiscus and hyaluronic acid can be used as a cosmetic adjuvant for improving common nail diseases such as nail fragility and onychomycosis, with significant results on nail quality and appearance. Patients did not report any adverse events and its ease of application and cosmetic qualities contribute to the great compliance to treatment.
Satisfaction with dental appearance in two cohorts of 75‐year‐olds examined in 2007 and 2017: A repeated cross‐sectional study
Authors: Johansson Anders , Omar Ridwaan , Carlsson Gunnar E. , Sannevik Josefin , Mastrovito Berit , Johansson Ann‐Katrin 
Published: August 2022

AbstractBackgroundSatisfaction with dental appearance plays an important role in the self‐esteem and psychological well‐being of the elderly, the significance of which the attending dentist may not always be fully cognisant of.ObjectivesTo assess the level of satisfaction with dental appearance, its associated factors and temporal changes in two cohorts of 75‐year‐old Swedes born 10 years apart.MethodsIn 2007, a questionnaire was mailed to all those living in Örebro and Östergötland counties, Sweden, who were born in 1932 (n = 5195), and in 2017 to all born in 1942 (n = 7204). The evaluation was carried out with a global question ‘Are you satisfied with the appearance of your teeth?’, and four attitude‐related statements about dental appearance.ResultsAbout 80% in both cohorts were ‘very satisfied’ or ‘to large extent satisfied’ with their dental appearance. The 1932 cohort was significantly more concerned about their dental appearance than the 1942 cohort, and women were generally also significantly more concerned than men. In the regression analysis, ‘very satisfied’ with dental appearance was predicted by good chewing efficiency, having complete dentures, no impact from Oral Impacts on Daily Performance, disagreement that ‘minor esthetic imperfections of the teeth have no importance, only they should function well’, better perceived general health than same‐aged peers and belonging to the 1932 cohort.ConclusionSatisfaction with dental appearance among 75‐year‐olds was generally high, with attitudes varying by gender and temporally. Women and the earlier‐born generation (1932) were more concerned about dental appearance than men and the later‐born generation (1942), respectively.
Complex population history affects admixture analyses in nine‐spined sticklebacks
Authors: Feng Xueyun , Merilä Juha , Löytynoja Ari 
Published: August 2022

AbstractIntrogressive hybridization is an important process in evolution but challenging to identify, undermining the efforts to understand its role and significance. On the contrary, many analytical methods assume direct descent from a single common ancestor, and admixture among populations can violate their assumptions and lead to seriously biased results. A detailed analysis of 888 whole‐genome sequences of nine‐spined sticklebacks (Pungitius pungitius) revealed a complex pattern of population ancestry involving multiple waves of gene flow and introgression across northern Europe. The two recognized lineages were found to have drastically different histories, and their secondary contact zone was wider than anticipated, displaying a smooth gradient of foreign ancestry with some curious deviations from the expected pattern. Interestingly, the freshwater isolates provided peeks into the past and helped to understand the intermediate states of evolutionary processes. Our analyses and findings paint a detailed picture of the complex colonization history of northern Europe and provide backdrop against which introgression and its role in evolution can be investigated. However, they also expose the challenges in analyses of admixed populations and demonstrate how hidden admixture and colonization history misleads the estimation of admixture proportions and population split times.
Dark nighttime interventions and sleep quality in intensive care unit patients: A systematic review and meta‐analysis
Authors: da Silva Higa Karina Thalita , Böhme Fernanda Aparecida Ferraro , Paschoa Simone , Conte Ana Cláudia Rodrigues , Santos Vinicius Batista , Avelar Ariane Ferreira Machado 
Published: August 2022

AbstractBackgroundSleep disturbances resulting from adverse clinical and environmental conditions are associated with unfavourable outcomes in critically ill patients.AimTo collect evidence on the effect of dark nighttime interventions on sleep quality and daytime sleepiness in intensive care unit (ICU) patients.Study DesignThe study followed the Preferred Reporting Items for Systematic reviews and Meta‐Analyses recommendations. This is a systematic review and meta‐analysis of experimental and quasi‐experimental studies, developed with adult patients admitted to ICUs and submitted to measures such as environmental brightness reduction, eye mask or blue light‐blocking glass use at night. Outcomes were subjective or objective sleep quality and excessive daytime sleepiness. Search was carried out in the PubMed/MEDLINE, Cochrane Library, Embase, Virtual Health Library, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Scopus databases, using grey literature. Covidence software, Cochrane tools and Grading of Recommendations Assessment, Development and Evaluation were used, and a meta‐analysis was performed using RevMan software.ResultsThirteen articles were included in the systematic review and seven studies were included in the meta‐analysis. There were 3 trials with 175 participants regarding lighting reduction and environmental noise control versus the usual routine, 2 of these trials, with 96 patients, were compiled in meta‐analysis in which it was observed a significant statistical improvement in subjective sleep quality, mean difference (MD) of 11.89 points (0–100); 95% confidence interval (CI) 8.0–15.76, evidence set with moderate certainty, as well as this same intervention, reduced daytime sleepiness in 2 trials, 135 participants (standardized MD −0.63; 95% CI −0.98 to −0.28), with low certainty evidence. Eye masks versus usual routine, 2 trials, 126 participants, improved subjective sleep quality (MD of 10 points; 95% CI 7.97–12.03), with moderate certainty of evidence. Eye mask use combined with other therapies versus usual routine, 5 trials, 204 participants, improved subjective sleep quality in all studies, with low certainty of evidence. Objective sleep assessment was not improved with these interventions.ConclusionsThis review shows some benefits of nighttime interventions on subjective sleep quality and excessive sleepiness, however, there is an urgent need to conduct better and more robust studies in this field.Relevance to Clinical Practiceapplying measures such as lighting reduction and eye mask use significantly improves sleep quality.
Supported self‐management in temporomandibular disorders: A systematic review of behavioural components
Authors: Palmer Julia , Penlington Chris , Durham Justin 
Published: August 2022

AbstractAimThe aim of this narrative systematic review is to use the behaviour change techniques taxonomy to identify the most frequently used behaviour change techniques in published supported self‐management (SSM) programmes to manage temporomandibular disorder (TMD) in adult patients.Materials and methodsElectronic database and manual searches were undertaken for randomized controlled trials assessing a SSM intervention for TMD. A definition of SSM was constructed from multiple sources and used as a basis for eligibility criteria. The relevant behaviour change technique (BCT) used within each SSM intervention was identified according to the definitions of the behaviour change taxonomy (version1).ResultsTwenty randomized controlled trials were identified as eligible for inclusion in this systematic review. No study tested multiple SSM programmes or tested SSM against no treatment or placebo. There was a wide variety in the number and types of BCTs used within the SSM interventions.ConclusionsEvidence regarding SSM is limited with significant differences identified between SSM programmes. Further research is required to test differing SSM programmes and to test the intervention against no treatment. Improved reporting of methodologies and consensus on the minimum required components to be used within a SSM intervention would improve comparison between studies.
Efficacy and safety of valbenazine in Japanese patients with tardive dyskinesia: A multicenter, randomized, double‐blind, placebo‐controlled study (J‐KINECT)
Authors: Horiguchi Jun , Watanabe Koichiro , Kondo Kazuoki , Iwatake Atsushi , Sakamoto Hajime , Susuta Yutaka , Masui Hideaki , Watanabe Yumi 
Published: August 2022

AimValbenazine is approved in the US for treatment of tardive dyskinesia (TD); however, efficacy/safety data in Asian populations are lacking. We assessed the efficacy/safety of valbenazine in Japanese patients.MethodsThis phase II/III, multicenter, randomized, double‐blind, placebo‐controlled study (NCT03176771) included adult psychiatric patients with TD, who were randomly allocated to receive placebo or valbenazine (once‐daily 40‐ or 80‐mg) for a 6‐week, double‐blind period, after which the placebo group was switched to valbenazine for a 42‐week extension. The primary endpoint was change from baseline in Abnormal Involuntary Movement Scale (AIMS) total score at Week 6; clinical global impression of improvement of TD (CGI‐TD) was also assessed.ResultsOf 256 patients, 86, 85, and 85 were allocated to the 40‐mg valbenazine, 80‐mg valbenazine, and placebo groups, respectively. Least‐squares mean (95% confidence interval) change from baseline in AIMS score at Week 6 was −2.3 (−3.0 to −1.7) in the valbenazine 40‐mg group, −3.7 (−4.4 to −3.0) in the 80‐mg group, and −0.1 (−0.8 to 0.5) in the placebo group; both treatment groups showed statistically significant improvements vs. placebo. Patients switched to valbenazine at Week 6 showed similar improvements in AIMS scores, which were maintained to Week 48. Improvements in CGI‐TD scores were observed for both treatment groups vs. placebo. Incidence of adverse events was highest in the 80‐mg group; common events included nasopharyngitis, somnolence, schizophrenia worsening, hypersalivation, insomnia, and tremor.ConclusionThe efficacy/safety profile of valbenazine was similar to that of previous clinical trials, supporting its use for TD treatment in Japanese patients.