bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cheilitis glandularis: case report and systematic literature review
Authors: de Sales Sarah Campos , Oliveira Sicília Rezende , Pantuzzo Erika Soares , Costa Fernanda Pereira Delgado , Xavier Marcus Henrique , de Mesquita Ricardo Alves , Abreu Lucas Guimarães , Campos Felipe Eduardo Baires , de Castro Wagner Henriques , Silva Tarcília Aparecida 
Published: March 2022

AbstractCheilitis glandularis (CG) is a rare inflammatory disease of unknown etiology that affects the minor salivary glands predominantly in the lower lip. In this article, we report the case of an 18‐year‐old black woman who presented with a deep suppurative type of CG in both lips. In addition, we performed a systematic literature review in five databases (PubMed, Scopus, Web of Science, Ovid, and Embase) to identify CG case reports or case series. A total of 360 references were retrieved in the electronic databases. Thirty‐four articles met the inclusion criteria, and six were retrieved through manual search, totaling 40 articles included in the systematic review. Thirty‐nine (68.4%) cases occurred in male individuals and 18 (31.6%) in female individuals. The mean age of affected individuals was 40.9 years. Different clinical manifestations ranging from no symptoms to discomfort, pain, swelling, erythema, eversion of the lip, dilated ductal openings, ulcers, and crust have been reported. Among the included CG cases, 41 affected exclusively the lower lip (71.9%). In four cases, the CG only affected the upper lip (7.0%). In 12 cases, the lesion affected both the lower and upper lips (21.1%). Different treatment modalities were adopted in the management of CG. Although the surgical treatment was indicated (42.1%), the conservative treatment with topical medications, as in the present case, resulted in resolution in 21.0% of cases.
Body Without End: Biological Mutualism and the Body of Christ
Authors: Malcolm Hannah 
Published: March 2022

AbstractThis article argues that the ecological turn towards biological mutualism enlivens our understanding of the eschatological promise contained in Christ’s resurrected and ascended body. I examine the implications of proposing that Christ’s body was not only incarnate as microbiome, but also rose and ascended as microbiome. First, I analyse contemporary approaches to Christology’s relation to creation and Andrew Davison’s theological exploration of mutualism. I then respond via Irenaeus’ defence of Christ’s bodily resurrection and ascension as promise for all flesh. By reading Irenaeus in light of the mutualistic body, we enrich our understanding of this promise: of fruitfulness for all creation, of fullness for human nature, and that fleshly life is no ultimate barrier to union with God. Finally, I propose that this reading also offers renewed insight into the Eucharist: this promise and its implications are also made manifest at the heart of the church, Christ’s body on earth.
Testicular cancer and YouTube: What do you expect from a social media platform?
Authors: Di Bello Francesco , Collà Ruvolo Claudia , Cilio Simone , La Rocca Roberto , Capece Marco , Creta Massimiliano , Celentano Giuseppe , Califano Gianluigi , Morra Simone , Iacovazzo Carmine , Coviello Antonio , Buonanno Pasquale , Fusco Ferdinando , Imbimbo Ciro , Mirone Vincenzo , Longo Nicola 
Published: March 2022

ObjectiveTo evaluate the quality information on testicular cancer uploaded on YouTube™ videos.MethodsYouTube™ videos were searched using “Testicular cancer” as a keyword. The Patient Education Materials Assessment Tool, the Misinformation scale, and the DISCERN tool were used to assess the quality information of YouTube™ videos on testicular cancer.ResultsAccording to the selection criteria, 121 YouTube™ videos were collected for the analysis and stratified according to uploading year (2009–2014 vs 2015–2020). According to the Patient Education Materials Assessment Tool for audio‐visual content, the overall Understandability score was 60% (interquartile range 45.5–75) and the overall Actionability score was 100% (interquartile range 66.7–100). According to the Misinformation scale, the lowest median was recorded for item 6 (“Effects on fertility”) and the overall median Misinformation score was 2 (interquartile range 1.3–2.8). No statistically significant differences were observed according to uploading year (all P > 0.05). Of all, only 54 (44.6%) videos mentioning treatment were subsequently analyzed. Of these videos, the overall Understandability was 71.4% (interquartile range 56.3–84.6) and the overall Actionability was 100% (interquartile range 66.7–100). The overall Misinformation score was 2.8 (interquartile range 2.2–3.5). The median DISCERN score recorded for question 16 was 5 (interquartile range 3–5).ConclusionsYouTube™ is a fast and open‐access source for mass information. The overall quality of the testicular cancer contents provided is sadly unsatisfactory, in the present likewise in the past. However, YouTube™ videos mentioning treatment options showed higher quality content, than the remaining one. Nevertheless, all the videos analyzed underestimated the testicular cancer effects on fertility. Nowadays, YouTube™ cannot be recommended as a reliable source of information on testicular cancer.
Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection
Authors: Laucirica Daniel R , Schofield Craig J , McLean Samantha A , Margaroli Camilla , Agudelo‐Romero Patricia , Stick Stephen M , Tirouvanziam Rabindra , Kicic Anthony , Garratt Luke W ,   Western Australian Epithelial Research Program (WAERP),   Australian Respiratory Early Surveillance Team for CF (AREST CF)
Published: March 2022

AbstractA population of neutrophils recruited into cystic fibrosis (CF) airways is associated with proteolytic lung damage, exhibiting high expression of primary granule exocytosis marker CD63 and reduced phagocytic receptor CD16. Causative factors for this population are unknown, limiting intervention. Here we present a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection. Pediatric primary airway epithelial cells were cultured at the air–liquid interface, challenged individually or in combination with rhinovirus (RV) and Pseudomonas aeruginosa, then apically washed with medical saline to sample epithelial infection milieus. Cytokine multiplex analysis revealed epithelial antiviral signals, including IP‐10 and RANTES, increased with exclusive RV infection but were diminished if P. aeruginosa was also present. Proinflammatory signals interleukin‐1α and β were dominant in P. aeruginosa infection milieus. Infection washes were also applied to a published model of neutrophil transmigration into the airways. Neutrophils migrating into bacterial and viral–bacterial co‐infection milieus exhibited the in vivo CF phenotype of increased CD63 expression and reduced CD16 expression, while neutrophils migrating into milieus of RV‐infected or uninfected cultures did not. Individually, bacterial products lipopolysaccharide and N‐formylmethionyl‐leucyl‐phenylalanine and isolated cytokine signals only partially activated this phenotype, suggesting that additional soluble factors in the infection microenvironment trigger primary granule release. Findings identify P. aeruginosa as a trigger of acute airway inflammation and neutrophil primary granule exocytosis, underscoring potential roles of airway microbes in prompting this neutrophil subset. Further studies are required to characterize microbes implicated in primary granule release, and identify potential therapeutic targets.
Activity and outcomes of autologous stem cell transplantation in the private sector in Australia
Authors: Nath Karthik , James Yvette , Taylor Debra , Gardner Raeina , Rai Nicholas , Ware Robert S. , Taylor Kerry , Morton James , Durrant Simon , Irving Ian , Bashford John 
Published: March 2022

AbstractBackgroundFew Australasian autologous stem cell transplantation (ASCT) programmes perform ASCT in the private sector. Relatively little is known about ASCT outcomes in the private sector, which varies in care delivery models to the public system.AimsTo investigate transplantation activity and survival outcomes at Icon Cancer Centre's Brisbane‐based private clinical and laboratory ASCT programme over a 23‐year period.MethodsRetrospective, observational study of all adults who underwent ASCT at Icon between 1996 and 2018. Main outcome measures were transplant activity, overall survival (OS) and 100‐day and 1‐year transplant‐related mortality (TRM). Outcomes were benchmarked against the Australasian Bone Marrow Transplant Recipient Registry (ABMTRR).ResultsBetween 1996 and 2018, 1676 ASCT were performed in 1454 patients. From 2010 to 2018, ASCT performed at Icon contributed 40% of all South East Queensland ASCT. In the past 5 years, 21% of Icon's patients were aged ≥70 years, compared with 5% across Australasia. For the entire cohort, 100‐day and 1‐year TRM was 1.1% and 1.7%, respectively, while for those aged ≥70 years, it was 2.0% and 3.1%. For ASCT performed between 2014 and 2018, 100‐day and 1‐year TRM was 0.8% and 1.4%, which was half the TRM rates reported by the ABMTRR. The 10‐year post‐transplant OS at Icon was higher than the ABMTRR data, across all disease subtypes.ConclusionWe report excellent OS and low TRM, demonstrating the critical role of the private sector in the administration of this highly complex therapy. The Icon ASCT programme is the largest ASCT contributor in Queensland. It is inclusive of patients aged ≥70 years, demonstrating low and acceptable TRM.
Factors associated with early uptake of COVID‐19 vaccination among healthcare workers in Azerbaijan, 2021
Authors: Doran Jason , Seyidov Nabil , Mehdiyev Samir , Gon Giorgia , Kissling Esther , Herdman Trent , Suleymanova Javahir , Rehse Ana Paula Couthino , Pebody Richard , Katz Mark A. , Hagverdiyev Gahraman 
Published: March 2022

AbstractIntroductionWe evaluated uptake and factors associated with COVID‐19 vaccination among health workers (HWs) in Azerbaijan.ResultsAmong 1575 HWs, 73% had received at least one dose, and 67% received two doses; all received CoronaVac. Factors associated with vaccination uptake included no previous COVID‐19 infection, older age, belief in the vaccine's safety, previous vaccination for influenza, having patient‐facing roles and good or excellent health by self‐assessment.ConclusionThese findings could inform strategies to increase vaccination uptake as the campaign continues.
Contract broiler farming as an effective pathway to improve rural prosperity in Indonesia
Authors: Setiadi Agus , Santoso Siswanto Imam , Mukson Mukson , Roessali Wiludjeng 
Published: March 2022

AbstractThis study investigates contract broiler farming as an effective scheme to improve rural prosperity through increased income using data compiled from a survey of randomly selected 158 broiler farm operations in Central Java and annual data collected from January to December 2020. Descriptive and regression analyses were used in this study. Farmers raised broilers, ranging from 5,400 to 20,000, about eight cycles a year in a closed‐house system. The number of broilers, feed conversion ratio (FCR), index performance, and harvested weight were hypothesised to influence income. Increasing index performance, number of broilers raised, length of rearing period, and harvested weight increased the broiler farm's income. Reducing FCR led to an increase in income. There was a positive correlation between the number of broilers raised and revenue and income. Contract broiler farming has improved the welfare of the rural community through increased income. Farmers earned high income from contract prices that was much higher than the production costs. It is recommended that broiler chicken contract farming should be disseminated to other farm communities in rural areas. As contract farming is suitable for medium‐ to large‐size farms, other schemes should accommodate small‐scale farms that dominate the domestic poultry industry.
Job experiences, challenges, revelations and narratives of nurse academics. A qualitative study
Authors: Singh Charanjit , Jackson Debra , Munro Ian , Cross Wendy 
Published: March 2022

AbstractAimTo explore the views and experiences of nurse academics about their professional work life.DesignA qualitative exploratory interview study.MethodsData were collected during 2018/2019 using a semi‐structured interview method with 19 experienced academic nurses from a range of academic levels in Australia. All interviews were audio recorded, transcribed verbatim and thematically analysed using a narrative approach. Ethics approval was granted by the relevant University Human Research Ethics Committee.ResultsParticipants provided detailed insights into the type of daily job stressors they faced. They shared narratives about their personal job experiences and how, at times, they chose to remain silent to maintain a cordial working relationship with some of their senior colleagues and leaders. The main themes were identified included a lack of work–life balance, incivility towards staff, increasing workloads and inequitable distribution, lack of recognition, negative workplace culture, lack of awareness of the importance of political astuteness and lack of leadership skills.ConclusionTo ensure a sustainable academic nursing workforce and provide a clearer understanding of job stress and what contributes to faculty decision to leave, areas of priority and strategies that needed attention were identified. These included effective mentoring of less‐experienced staff and leadership styles that promote greater inclusiveness, being heard, valued and recognized, improved work–life balance and the need to have a sense of belonging.ImpactThe study explored the job experiences of nurse academics and identified occupational stressors that directly influenced their daily work life. The findings have global implications for the recruitment and sustainability of nurse academics. This also impacts on their professional and work–life balance.
Employment preferences of individuals with intellectual and developmental disabilities: An evaluation of gender and age differences
Authors: Hennessey Robin E. , Goreczny Anthony J. 
Published: March 2022

AbstractBackgroundEmployment is often central to individuals' lives. However, individuals with intellectual or developmental disabilities are often absent from the workplace, and little research has examined their interest in working.AimsThis study examined whether people with intellectual and/or developmental disabilities want jobs; why they do or do not want jobs; and, if they want to work, what types of jobs they would like to have.Materials and MethodsOur analyses consisted of 629 participants (379 male, 248 female, 2 unspecified) who participated in an interview.ResultsResults suggested that many individuals with intellectual or developmental disabilities want jobs. Our study identified gender differences in vocational interests and motivation for employment. There were no significant differences between age groups.Discussion and ConclusionIn the future, research could expand upon these findings by exploring how various factors, such as other social identities, affect vocational interests of individuals with intellectual or developmental disabilities.
Soil chemical variables improve models of understorey plant species distributions
Authors: Roe Nathan A. , Ducey Mark J. , Lee Thomas D. , Fraser Olivia L. , Colter Robert A. , Hallett Richard A. 
Published: March 2022

AbstractAimSpecies distribution models (SDMs) assume that all ecologically relevant predictor variables are included. This assumption is frequently violated in SDMs of plant species, as soil variables are rarely included. Here, we used in‐situ, soil geochemical variables along with more commonly used topo‐climatic and remotely sensed variables to create SDMs of understorey plant species. We evaluated whether the potential importance of soil variables is greater than generally described in SDM literature, which predictors are most important, and whether a standard subset of predictors can be used to effectively model all species.LocationNorthern Appalachian Mountains.TaxonVascular, forest understorey plants.MethodsWe fit models for the presence of 41 forest understorey plant species across 158 plots using soil, topographic and spectral predictors.ResultsModels containing all three predictor types performed best. Soil and topographic variables had comparable importance; spectral variables were of lesser importance. The best predictor variable was B horizon carbon to nitrogen ratio (B C:N), followed by topographic position index, elevation and B horizon exchangeable calcium (B Ca). A standard subset of variables did not effectively model all species.Main conclusionsOur results and those of other SDMs that include in‐situ soil geochemical data suggest that soil variables are increasingly important with more detailed descriptions of soils. Soil fertility data, such as B C:N and B Ca, are particularly important in acidic, forest soils where pH is a poor indicator of fertility. Commonly used topo‐climatic variables provide meaningful predictions but are limited by their use of indirect predictor variables, inhibiting transferability and interpretability. The poor performance of a standard subset of variables highlights the uniqueness of each species' niche and the need to have a variety of predictor variables.
Ascorbate peroxidase 1 confers resistance to southern corn leaf blight in maize
Authors: Zhang Jinghua , Jia Xingmeng , Wang Guan‐Feng , Ma Shijun , Wang Shunxi , Yang Qin , Chen Xueyan , Zhang Yuqian , Lyu Yajing , Wang Xiaoxu , Shi Jiawei , Zhao Yangtao , Chen Yanhui , Wu Liuji 
Published: March 2022

AbstractSouthern corn leaf blight (SCLB), caused by Bipolaris maydis, is one of the most devastating diseases affecting maize production. However, only one SLCB resistance gene, conferring partial resistance, is currently known, underscoring the importance of isolating new SCLB resistance‐related genes. Here, we performed a comparative proteomic analysis and identified 258 proteins showing differential abundance during the maize response to B. maydis. These proteins included an ascorbate peroxidase (Zea mays ascorbate peroxidase 1 (ZmAPX1)) encoded by a gene located within the mapping interval of a previously identified quantitative trait locus associated with SCLB resistance. ZmAPX1 overexpression resulted in lower H2O2 accumulation and enhanced resistance against B. maydis. Jasmonic acid (JA) contents and transcript levels for JA biosynthesis and responsive genes increased in ZmAPX1‐overexpressing plants infected with B. maydis, whereas Zmapx1 mutants showed the opposite effects. We further determined that low levels of H2O2 are accompanied by an accumulation of JA that enhances SCLB resistance. These results demonstrate that ZmAPX1 positively regulates SCLB resistance by decreasing H2O2 accumulation and activating the JA‐mediated defense signaling pathway. This study identified ZmAPX1 as a potentially useful gene for increasing SCLB resistance. Furthermore, the generated data may be relevant for clarifying the functions of plant APXs.
Urban‐Rural Differences in Depression Literacy Among High School Teachers in the Kingdom of Eswatini
Authors: Ngwenya Thabo Zwelethu , Huang Nicole , Wang I‐An , Chen Chuan‐Yu 
Published: March 2022

ABSTRACTBACKGROUNDConcerns have been raised over teachers' mental health literacy in low‐income countries and lower‐ and middle‐income countries wherein pediatric mental health resources are limited. This study aims to investigate adolescent depression literacy among teachers in Eswatini and to explore the role of urbanicity.METHODSWe conducted a cross‐sectional survey in 59 public high schools in Eswatini in 2019‐2020. Data were collected by a paper‐and‐pencil questionnaire; depression literacy was assessed by the 17‐item Adolescent Depression Knowledge Questionnaire.RESULTSTeachers' adolescent depression literacy item‐level correct rates fell between 27 and 80%. Although the multivariate response models indicated that teaching in urban areas was slightly associated with having higher depression literacy in general (adjusted odds ratio [aOR] = 1.46; 95% confidence interval = 1.00‐2.12), such urban‐rural differences did not manifest homogeneously across all items: urban teaching was significantly linked with reduced correct responses toward certain items concerning depression etiology and treatment, including “depression runs in some families,” “major stress as a necessary cause,” and “a curable illness” (aOR = 0.57 ∼ 0.68).CONCLUSIONUrban‐rural differences in teachers' depression literacy were manifested at both scale‐ and item‐levels. A critical need exists for urban/rural areas‐tailored intervention on teachers' literacy toward mental disorders in the resource‐limited regions to better improve health and developmental outcomes of students.
Myoclonus in older Cavalier King Charles Spaniels
Authors: Rotter Carina , Whittaker Danielle , Rusbridge Clare 
Published: March 2022

AbstractBackgroundMyoclonus is observed in older Cavalier King Charles Spaniels (CKCS) but a full description is lacking.ObjectivesThe presence, age of onset, characteristics and treatment of myoclonic episodes were retrospectively evaluated in a cohort of CKCS which presented to 1 board‐certified neurologist. Clinical data, imaging studies, presence of seizures and their management, as well as other comorbidities were noted.AnimalsThirty‐nine CKCS that were presented to 2 institutions between 2001 and 2018 with signs consistent with myoclonus. Clinical examination, blood sampling, advanced diagnostic imaging, cerebrospinal fluid analysis, and record keeping of other comorbidities was performed.MethodsThis is a retrospective case series, describing the presence of myoclonus in CKCS.ResultsClinical signs reported were spontaneous in onset, lasted a few seconds and consisted of rapid blinking with head nodding and variable extension down the thoracic limbs. Myoclonus occasionally led to stumbling of the thoracic limbs or collapse. Mean age of onset was 8.38 years (SD ±1.96). Thirteen of 39 dogs with myoclonus had paroxysmal events, such as generalized seizures (9/13).Conclusions and Clinical ImportanceMyoclonus occurs in middle‐aged to older CKCS and seems to be another epiphenomena of this breed. A link to epilepsy might be present.
New directions in Jane Austen studies
Authors: Greenfield Sayre N. , Troost Linda V. 
Published: March 2022

AbstractThis essay identifies emerging trends in Jane Austen scholarship published between 2010 and 2020, with a focus on monographs and edited collections. In recent work examining Austen through contemporary theoretical and critical lenses, the following new topics have been central: material culture, animal studies, masculinity, place, and celebrity. The last of these includes Austen's use of Regency celebrities in her novels and her connections with other women writers. Studies of the parallels between her and Shakespeare's rises to fame have also surged. Connected to the interest in celebrity is the explosion of fan‐culture studies: Austen is now a multimedia superstar with wide appeal. This expansion of audience has meant a shift in the style of much scholarly writing on Austen as books try to cater to both academic and non‐academic markets.