bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Role of miR-195 in Head and Neck Squamous Cell Carcinoma: Systematic Review with Meta-Analysis and Trial Sequential Analysis
Authors: Dioguardi Mario , Spirito Francesca , Sovereto Diego , Femina Lucia La , Caloro Giorgia Apollonia , Cosola Michele Di , Cantore Stefania , Ballini Andrea , Muzio Lorenzo Lo , Troiano Giuseppe 
Published: June 2022

Abstract
Head and neck squamous cell carcinoma (HNSCC) represent a heterogeneous group of neoplasms whose histological derivation comes from the lining epithelium of the mucous membranes: the oral cavity, the larynx, the hypopharynx, the nasopharynx and the oropharyx The etiopathogenetic mechanisms involving tumor genesis, including alteration of cell proliferation, apoptosis, invasion, migration and death, may involve alterations in the expression of MICRORNA. To date there are no systematic reviews with meta-analyzes conducted specifically on the role of miR-195 in HNSCC, our hypothesis is that with the presence in the literature of recent studies conducted on miR-195 it is possible to clearly determine, by aggregating the results, if the aberrant expression of miR-195 in HNSCC tissues may represent a prognostic biomarker of survival through Hazard Ratio (HR) and RR analysis. The systematic review was reported following the indications of the PRISMA and 3 electronic databases were used, such as PubMed, Scopus and Chocrane central Trial and the gray literature and a combination of keywords was used, such as miR-195 AND HNSCC, microRNA AND HNSCC and miR − 195. The meta-analysis and Trial sequential analysis were performed using RevMan 5.41 software and TSA software (Cochrane Collaboration, Copenhagen, Denmark). This search identified 1592 articles, at the end of the selection process 3 articles were included. The results of the meta-analysis report an aggregate risk ratio (RR) for overall survival (OS), between the expression of miR-195 highest and lowest, of 0.36, 6 95% CI: [0.25, 0.51] heterogeneity was evaluated through Chi² = 0.05 df = 2 (P = 0.98) and the Higgins index I² = 0% ; The test for the overall effect is Z = 5.77 (P < 0.00001). the forest plot is in favor of higher OS in patients with high miR-195 expression.
Effect of Water Type Used in Mixing the Alginate on the Final Stone Cast of Removable Partial Dentures
Authors: monther Bassil , Belal Ammar 
Published: June 2022

Abstract
Introduction: Recording an accurate impression is one of the most important steps in prosthetic dentistry for a successful denture, alginate remains one of the most common impression materials in dentistry, Therefore, it is important to fully understand its characteristics and the factors that influence it in order to avoid possible complications.Purpose: Study the effect of water type used in mixing the alginate on the final stone cast of removable partial dentures using different types of water.Materials and Methods: The research sample consisted of 30 gypsum casts taken with alginate for partially edentulous metal cast class III modification 2, divided into three equal groups according to the different type of water used in mixing the alginate (distilled water, mineral water, tap water). The linear measurements were made in the longitudinal, vertical, and transverse dimensions according to points prepared in advance on the metallic cast using a digital caliper, then it was repeated on gypsum casts. The results were collected and analyzed statistically by the t-student, Anova, and Bonferroni method at a 95% confidence level.Results: It was found that there were changes in the linear dimensions in all groups, regardless of the type of water used, but to varying degrees between them without statistically significant differences, except for the front vertical linear dimension which was the largest in the tap water group.Conclusions: Within the limits of this study, we can say about the preference of distilled and mineral water in mixing alginate for final impressions compared to tap water.Recommendations: We recommend the use of distilled or mineral water when mixing alginate for final impressions.
Predicting vulnerable sites and causative factors of bank erosion in river Ganga (Malda, India) using remote sensing and statistical modeling approach
Authors: GHOSH DEBARSHI , Saha Snehasish 
Published: June 2022

Abstract
This study aims to evaluate the causative factors for high bank erosion probability along the left bank of Ganga river in Malda district using binary logistic regression model. The bank erosion at the outer bend of Ganga in Manikchak and Kaliachak-II blocks during the recession of flood water in Ganga poses serious threats to the inhabitants of Diara since the construction of the Farakka barrage. The constriction slowly started a problem of water pilling at the up-stream of the barrage and extended up to the Bhutni Island (40 km up stream). The seepage mechanism allows the entry of rising flood water to the banks and again released when water level recedes gradually and causes bank slumping. In last monsoon (2020), Gopalpur, Jotbhabani Dharampur gram panchayets of Manikchak block are heavily affected by bank erosion. Total nine causative factors are selected as predictor variables in binary logistic regression model categorized broadly as vegetation, water and moisture indices, proximity based on river channel and settlement, soil characteristics and landuse-cover classes. The omnibus test of model coefficient gives the likelihood ratio (224.433) for the overall model fitting (p value 0.0). The model predicts correctly 254 sites as low bank erosion (LBE) and 111 sites as High bank erosion (HBE) category with 84.4% and 67.3% accuracy. The soil bearing capacity significantly expresses highest odds (87.6%) of telling the high probability of bank erosion. The model produces accuracy up to 87.4%.
L1 gene based Molecular Characterization of Bovine papillomavirus type 1 (BPV1) isolated from cutaneous warts of cattle, Maharashtra (India)
Authors: Tumlam U. M. , Desai D. N. , Pawade M. M. , Mhase P. P. , Muglikar D. M. 
Published: June 2022

Abstract
Bovine Papillomatosis (BP) is a contagious disease of the animals in which it naturally occurs. It is caused by the bovine papillomavirus (BPV) and is characterized by warts that occur in cutaneous and mucosal forms. Cattle are affected by six different types of papillomaviruses. BPV-1 and − 2 infections can cause warts on the skin, teats, udders, penis, and tumors in the urinary bladder. In the present study, total of 10 wart samples from cattle were studied. PCR was performed to detect the presence of BPV and its type. Further, the PCR amplified product was sent for the sequencing for the confirmation and phylogeny analysis. The result revealed that the cutaneous warts of six cattle were positive for BPV-1 while all the samples were found negative for BPV-2. BPV-1 was detected in cutaneous warts by a PCR and was confirmed by nucleotide sequencing and phylogenetic analysis. In conclusion, the BPV type prevalent in the cutaneous warts of Indian cattle is the BPV-1 type.
Early fluid activity on Ryugu: perspectives from oxygen, carbon, and 53Mn-53Cr isotopes
Authors: McCain Kaitlyn , Matsuda Nozomi , Liu Ming-Chang , McKeegan Kevin , Yamaguchi Akira , Kimura Makoto , Tomioka Naotaka , Ito Motoo , Imae Naoya , Uesugi Masayuki , Shirai Naoki , Ohigashi Takuji , Greenwood Richard , Uesugi Kentaro , Nakato Aiko , Yogata Kasumi , Yuzawa Hayato , Kodama Yu , Hirahara Kaori , Sakurai Ikuya , Okada Ikuo , Karouji Yuzuru , Nakazawa Satoru , Okada Tatsuaki , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Yoshikawa Makoto , Miyazaki Akiko , Nishimura Masahiro , Yada Toru , Abe Masanao , Usui Tomohiro , Watanabe Sei-ichiro , Tsuda Yuichi 
Published: June 2022

Abstract
Samples from asteroid Ryugu returned by the Hayabusa2 mission contain evidence of extensive alteration by aqueous fluids and appear related to the CI chondrites. To understand the sources of the fluid and the timing of chemical reactions occurring during the alteration processes, we investigated the oxygen, carbon, and 53Mn-53Cr systematics of carbonate and magnetite in two Ryugu particles. We find that the fluid was initially between 0 − 20°C and enriched in 13C, and 17O and 18O, and subsequently evolved towards lighter carbon and oxygen isotopic compositions as alteration proceeded. Carbonate ages show that this fluid-rock interaction took place within the first ~ 1.4 million years of solar system history requiring early accretion and preservation of carbonaceous material, either in a planetesimal less than ~ 17 km in diameter or a larger body which was disrupted and reassembled.
COVID-19: Monitoring of patients’ laboratory data during a 90-day length of hospital stay
Authors: Perraud Eunice Bobô de Carvalho , Oliveira Breno Douglas Dantas , Meireles Lilia Sousa Martins Alcântara , Moreira Thainá Bastos Mangueira , Loureiro Vinicius Lopes , Rocha Hermano Alexandre Lima , Martins Filadélfia Passos Rodrigues 
Published: June 2022

Abstract
Background: In March 2020, COVID-19 was declared a pandemic. In this study, patients were selected through the chest HRCT diagnosis. Laboratory tests such as blood count, fibrinogen, D-dimer, AST, ALT, troponin, LDH, albumin, CRP, electrolytes and ferritin were analyzed. Aims: To monitor the laboratory evolution of COVID-19 in patients during hospitalization. Method: Of 115 patients, 93 were selected and analyzed every three days for 90 days. Data were analyzed using the IBM, SPSS, Statistics for Windows, 23.0 software. Results: 34.4% were female, and 65.6% male; Hct and Hb dropped after the 13th day of hospitalization; leukocyte levels remained up to 15,000, increasing to >20,000 after the 55th day of hospitalization; lymphopenia occurred in 10 to 15% of the patients, with increased eosinophils; platelet levels decreased at the end of hospitalization. Fibrinogen, D-dimer, LDH, CRP and ferritin levels increased throughout the hospitalization period. Urea and creatinine increased slightly from the 30th day onwards. There were no alterations in PTA, troponin, chlorine, potassium and albumin levels, with a decrease throughout the hospitalization period. Conclusion: Knowledge of the behavior of laboratory tests together with the disease evolution give support to the clinical and therapeutic management of COVID-19.
The Antibacterial and Antibiofilm Properties of Different Strains of Lactobacillus spp. Isolated from Traditional Kefir Dough on Oral Pathogens with Real Time PCR
Authors: ekhteraei khatereh sadat , Narimani Tahmineh , poursina farkhondeh , Mirzaei Arezoo , Damavandi Mohammad Sadegh 
Published: June 2022

Abstract
Oral illnesses such as dental caries and gingivitis are frequent. In these kinds of infection, the bacteria are thought to use biofilm formation as a pathogenic mechanism. Today, due to the side effects of chemical medications and resistance to antibiotics, the use of probiotics is of great importance as a suitable alternative way for infection treatment. Probiotics have shown favourable properties in terms of maintaining oral health. Kefir, which is made up of complex microbiota mainly Lactobacillus spp., has been suggested as a potential reservoir for probiotic. The present research aimed to isolate and identify lactic acid bacteria from traditional kefir dough as a probiotic that suppresses S. mutans and P. gingivalis growth, biofilm formation, and gene expression. In this study, Lactobacillus spp. was tested for antibacterial (well agar diffusion technique) and antibiofilm (crystal violet assay) properties against Streptococcus mutans (ATCC 35668) and Porphyromonas gingivalis (ATCC 33277). Through the use of real-time polymerase chain reaction, we explored whether Lactobacillus plantarum and Lactobacillus rhamnosus inhibited expression of Streptococcus mutans genes involved in biofilm formation and stress survival. Additionally, Lactobacillus plantarum and Lactobacillus rhamnosus dramatically inhibited the expression of gtfB and brpA.
Comparison between diffusion-weighted imaging and post-contrast enhanced T1-weighted sequence in brain MRI of patients with an acute attack of multiple sclerosis and the role of serum vitamin D3 level in its diagnosis
Authors: Nazeri Masoume , Owjfard Maryam , Poursadeghfard Maryam , Ashjazadeh Nahid , Bazrafshan Mehdi , Ghasemi Mahsa , Bazrafshan Hanieh 
Published: June 2022

Abstract
Background and purpose. – Identifying multiple sclerosis (MS) lesions is cornerstone in the diagnosis and prognosis of the disease activity. Application of contrast-enhanced magnetic resonance imaging (CE-MRI) is vital but the alternative use of diffusion-weighted imaging (DWI) and biomarkers is most appropriate when the injection of contrast agents is contraindicated. The present study investigated the possible substitution of CE-MRI with DWI and determined a vitamin D3 cutoff point for MS patients with positive MRI.Materials and Methods. – 5 ml of peripheral venous blood was collected from all patients and DWI and post-contrast T1-weighted MRI were performed on 85 patients with acute attacks of MS from April 2018 to November 2019. Contrast-enhanced lesions were considered the gold standard of activity in MRI in evaluating the relation between CE-MRI and DWI.Results. – The accuracy of CE-MRI was higher (63.5%) compared to DWI (27.1%). Majority of patients (54) showed positive results in CE-MRI. The difference between patients with and without positive CE-MRI was statistically significant in terms of vitamin D3 deficiency (P=0.001). The optimal cutoff of vitamin D3 for CE-MRI positive patients was 23.33 ng/ml with 83.33% sensitivity and 61.29% specificity. Conclusions. – Combination of CE-MRI and DWI yields more positive imaging results; DWI sequence alone, without using T1 with contrast in MRI, is not enough to assess brain lesion activity in patients with MS. Furthermore, vitamin D3 levels of <23.33 ng/ml correlate well with a positive result in CE-MRI where the MS activity is most likely to be present.
De novo or continuation of Intractable Headache with Autonomic Features even after Treatment of Hypophyseal Macroadenoma: Case Series Report
Authors: Togha Mansoureh , Moghadasi Abdoreza Naser , Haghighi Samaneh , Rapoport Alan M. , Motamedi Mahmood 
Published: June 2022

Abstract
Headache is a known complication of the pituitary lesion. Different treatment methods such as surgery and radio-surgery used to treat these tumors, there are some reports of patients in whom preoperative headaches still exist after surgery or de novo postoperative headache started.Here we report 4 cases of headaches under vented transsphenoidal surgery of pituitary lesions. These patients had been referred to the Headache Clinic of Sina Hospital, Tehran, Iran since 2012. Headaches were strictly unilateral, mostly in the left periorbital area, and were accompanied by ipsilateral autonomic features. As these types of headaches were so similar, and no CSF leak, abscess, pneumocephalus, cerebral infection or hemorrhage, meningitis, and hydrocephalus were found for them and they were resistant to different treatment modalities, we considered them to report for more attention.
Bioactivity of an organic farming aid with possible fungistatic properties against some oil palm seedling foliar pathogens
Authors: Obeng Joshua , Agyei-Dwarko Daniel , Teinor Peter , Danso Isaac , Lutuf Hanif , Lekete-Lawson Emmanuella , Ablormeti Fred Kormla , Eddy-Doh Mary Akpe 
Published: June 2022

Abstract
Synthetic fungicides are necessary evil in crop production, their usage cannot be neglected or abandoned but must be alternated/supplemented with other control measures such as cultural, host resistance and biocontrol methods to reduce their detrimental effect on the environment and living organisms. A bioproduct (wood vinegar) was evaluated against oil palm seedling pathogens at CSIR – Oil Palm Research Institute, Kusi at different concentrations and compared with an inorganic fungicide at the manufacturer’s recommended dosage. Disease pathogens were isolated from collected diseased leaf samples and pure cultures were established on cPDA. PDA was amended with wood vinegar ranging from 0 to 3.35% and 0.1%v/v of carbendazim as a positive control. Daily colony growth was measured in two diagonal lengths and averages of day 6 and day 7 were used to calculate the inhibition percentage for both pathogens. 11 mm/day was the lowest average growth rate recorded for 2.68% v/v of wood vinegar and 14.17 mm/day on control plate of Curvularia species. There was no significant difference between 0.1%v/v carbendazim, 2.68 and 3.35% v/v against Curvularia species whilst significantly, there was difference between 0.1%v/v carbendazim and 2.68 and 3.35%v/v of wood vinegar against Pestalotiopsis species.
The Naturalized Vascular Flora of Malesia
Authors: Holmes Rachael , Pelser Pieter , Barcelona Julie , Tjitrosoedirdjo Sri Sudarmiyati , Wahyuni Indah , Kleunen Mark van , Pyšek Petr , Essl Franz , Kreft Holger , Dawson Wayne , Wijedasa Lahiru , Kortz Alessandra , Hejda Martin , Berrio Juan Carlos , Siregar Iskandar , Williams Mark 
Published: June 2022

Abstract
Major regional gaps exist in the reporting and accessibility of naturalized plant species distribution data, especially within Asia. Here, we present the Malesian Naturalized Alien Flora database (MalNAF), the first standardized island-group level checklist of naturalized vascular plant species for the Malesian phytogeographical region. We used MalNAF to investigate the composition, origins, and habitat preferences of the naturalized flora, as well as potential drivers of taxonomic species richness across the archipelago. The naturalized vascular flora of Malesia consists of at least 1,345 species. Richness is highest in Singapore (569 spp.) and lowest in the Maluku Islands (87 spp.). Across the archipelago, 32 species are widespread, occurring in every island group, but the majority have a limited distribution of 2.3 ± 2.2 island groups per naturalized species. The naturalized plant species are representatives of 163 families, twenty of which are newly introduced to the region. Families richest in naturalized plant species in Malesia were Fabaceae (= Leguminosae) (171 spp.), Poaceae (= Gramineae) (160 spp.), and Asteraceae (= Compositae) (103 spp.). Overall, most of these have a native range that includes tropical Asia, closely followed by those with a range in Southern America, although at the island-group level, most have a higher proportion with a Southern American native range. Most naturalized species occur in anthropogenic habitats, but a few occur in specialised habitats. Human population density was the most significant driver of naturalized richness in Malesia. MalNAF provides a baseline for future studies of naturalized plant species distributions in the region.
A search to reducing Striga hermonthica (Del.) Benth propagation using plant aqueous extracts with bio-herbicide properties on the seeds in vitro
Authors: SAWADOGO-ILBOUDO Tinkoudougou Cathérine , YONLI Djibril , SOURABIE Soumaïla , ZERBO Patrice , TRAORE Hamidou , BOUSSIM Joseph Issaka 
Published: June 2022

Abstract
Background
The genus Striga includes 11 parasitic plants species of food crops in at least 50 African countries. Striga hermonthica (Del.) Benth. is a major biotic constraint to the cereal crops production in Africa. It is the most widespread species in fields in Burkina Faso and grows on all types of soil inducing losses estimated at 35–40% on sorghum and millet. The significant reductions in yields result in insufficient food for the populations.
Methods
This study aims to identify local plants with bio-herbicidal properties for the management of Striga hermonthica. The inhibiting and stimulating effect of aqueous extracts from 13 local plant species on the germination of Striga seeds was assessed in vitro.
Results
The aqueous extracts from the leaves of Azadirachta indica A. Juss, Jatropha curcas L., Jatropha gossypiifolia L., Lawsonia inermis L. and those from the leafy stems of Cassia obtusifolia L., Crotalaria retusa L., Phyllanthus amarus L. completely inhibited germination of Striga. However, those from five plants significantly stimulated germination of which the highest germination rate (60%) was recorded with the extract from Euphorbia hirta L. leafy stems.
Conclusions
The plant extracts thus constitute an ecological avenue for Striga. control. Further experiments could lead to the formulation of bio-herbicides against the parasitic plant to improve cereal production while limiting environmental pollution.
Girl Predominance in Trampoline-based Forearm Shaft Fractures and Their Increasing Incidence since 2000
Authors: Stöckell Markus , Pikkarainen Ella , Pokka Tytti , Sinikumpu Juha-Jaakko 
Published: June 2022

Abstract
Background: There are reports of increasing incidence of forearm shaft fractures in children. Their treatment has been preferably nonoperative but surgical fixation has gained popularity due to elastic stable intramedullary nailing. We aimed to study whether the incidence of paediatric both-bone forearm shaft fractures and their operative care have changed since year 2000. We also aimed to evaluate trampoline injuries, and other injuries, re-displacement rate and short-term outcomes of these fractures.Methods: A population-based study in the geographic catchment area of Oulu University Hospital district in 20-years of time period (2000 – 2019) was performed. Altogether 481 diaphyseal both-bone forearm fractures in children (<16 years) were included. The age- and sex-related incidence rates were determined, by using the official numbers of the population-in-risk by Statistics Finland. Trampoline jumping and other types of injury were reviewed, as well as particulars of treatment and outcomes. Results: The incidence of diaphyseal both-bone forearm fractures increased from 9.4/100 000 in 2000-2001 to 41.7/100 000 in 2018-2019 (P<0.001). Surgical treatment increased respectively (from 8.8/100 000 in 2000-2001 to 35.3/100 000 in 2018-2019, P<0.0001). Trampoline injuries explained one in three (29%) of all fractures; they increased from 0% in 2000-2001 to 36.6% in 2018-2019 (P<0.001). During the last four years of the study (2016-2019), most trampoline-related injuries occurred among girls (61.2%), compared to boys (38.8%) (P=0.031). Trampoline-related injuries comprised 46.9% of all fractures in girls, compared to 26.0% among boys (Diff. 20.8%, 4.7% to 36.1%, P=0.009). The mean age of the patients elevated from 6.4 years (2000-2001) to 8.6 years (2018-2019) (P=0.015). Boys predominated (69.6%) in 2000-2009 but during the last ten years, there was no statistical difference in distribution between the genders (males 54.6%, P=0.11).Conclusions: During the twenty-year’s of study period, the incidence of paediatric diaphyseal forearm fractures increased 4.9-fold. Trampolining was the most usual reason for the fractures. More attention should be focused to increase the safety of trampoling, in particular among the girls.