bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemsex and incidence of sexually transmitted infections among Canadian pre-exposure prophylaxis (PrEP) users in the l’Actuel PrEP Cohort (2013–2020)
Authors: Flores Anato Jorge Luis , Panagiotoglou Dimitra , Greenwald Zoë R , Blanchette Maxime , Trottier Claire , Vaziri Maliheh , Charest Louise , Szabo Jason , Thomas Réjean , Maheu-Giroux Mathieu 
Published: January 2022

ObjectivesUse of illicit substances during sex (chemsex) may increase transmission of HIV and other STIs. Pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV transmission, providing an important prevention tool for those who practise chemsex. However, it does not prevent acquisition of other STIs. We aim to examine the impact of chemsex on STI incidence among gay, bisexual and other men who have sex with men (gbMSM), and transgender women using PrEP in Montréal, Canada.MethodsWe linked baseline sociodemographic and behavioural data with follow-up STI testing from 2013 to 2020 among PrEP users in the l’Actuel PrEP Cohort (Canada). Focusing on the 24 months following PrEP initiation, we estimated the effect of chemsex reported at baseline on cumulative incidence of gonorrhoea and chlamydia using Kaplan-Meier curves and survival analyses. We investigated the role of polysubstance use and effect modification by sociodemographic factors.ResultsThere were 2086 clients (2079 cisgender gbMSM, 3 transgender gbMSM, 4 transgender women) who initiated PrEP, contributing 1477 years of follow-up. There were no incident HIV infections among clients on PrEP. Controlling for sociodemographic confounders, clients reporting chemsex at baseline had a 32% higher hazard of gonorrhoea/chlamydia diagnosis (adjusted HR=1.32; 95% CI: 1.10 to 1.57), equivalent to a risk increase of 8.9 percentage points (95% CI: 8.5 to 9.4) at 12 months. The effect was greater for clients who reported polysubstance use (adjusted HR=1.51; 95% CI: 1.21 to 1.89). The strength of the effect of chemsex on STI incidence varied by age, education and income.ConclusionAmong PrEP users, chemsex at baseline was linked to increased incidence of gonorrhoea and chlamydia. This effect was stronger for people reporting multiple chemsex substances. The high STI incidence among gbMSM who report chemsex highlights the importance of PrEP for this population and the need for integrated services that address the complexities of sexualised substance use.
Scaling High-Quality Pairwise Link-Based Similarity Retrieval on Billion-Edge Graphs
Authors: Yu Weiren , McCann Julie , Zhang Chengyuan , Ferhatosmanoglu Hakan 
Published: January 2022

SimRank is an attractive link-based similarity measure used in fertile fields of Web search and sociometry. However, the existing deterministic method by Kusumoto et al. [24] for retrieving SimRank does not always produce high-quality similarity results, as it fails to accurately obtain diagonal correction matrix D. Moreover, SimRank has a “connectivity trait” problem: increasing the number of paths between a pair of nodes would decrease its similarity score. The best-known remedy, SimRank++ [1], cannot completely fix this problem, since its score would still be zero if there are no common in-neighbors between two nodes.In this article, we study fast high-quality link-based similarity search on billion-scale graphs. (1) We first devise a “varied-D” method to accurately compute SimRank in linear memory. We also aggregate duplicate computations, which reduces the time of [24] from quadratic to linear in the number of iterations. (2) We propose a novel “cosine-based” SimRank model to circumvent the “connectivity trait” problem. (3) To substantially speed up the partial-pairs “cosine-based” SimRank search on large graphs, we devise an efficient dimensionality reduction algorithm,PSR#, with guaranteed accuracy. (4) We give mathematical insights to the semantic difference between SimRank and its variant, and correct an argument in [24] that “ifDis replaced by a scaled identity matrix (1-Ɣ)I, their top-K rankings will not be affected much”. (5) We propose a novel method that can accurately convert from Li et al. SimRank ~{S} to Jeh and Widom’s SimRankS. (6) We proposeGSR#, a generalisation of our “cosine-based” SimRank model, to quantify pairwise similarities across two distinct graphs, unlike SimRank that would assess nodes across two graphs as completely dissimilar. Extensive experiments on various datasets demonstrate the superiority of our proposed approaches in terms of high search quality, computational efficiency, accuracy, and scalability on billion-edge graphs.
A Urinary Drug-Disposing Approach as an Alternative to Intravesical Chemotherapy for Treating Nonmuscle Invasive Bladder Cancer
Authors: Bellat Vanessa , Michel Adam O. , Thomas Charlene , Stokol Tracy , Choi Benjamin B. , Law Benedict 
Published: January 2022

Abstract

The standard treatment of nonmuscle invasive bladder cancer (NMIBC) is transurethral resection of the tumors, followed by intravesical therapy (IT), which comprises a direct instillation of a solution of Bacillus Calmette-Guérin vaccine or chemotherapy into the bladder. However, the recurrence rate in this disease remains unacceptably high. IT is a local treatment that fails to reach tumors developed in the upper urinary tract (ureter and renal pelvis). The catheterization procedure required for IT is invasive, painful, and poses an increased infection risk, resulting in poor patient quality of life and compliance. There is an unmet need for a potent, comprehensive, and noninvasive option. Without chemical modifications, peptides are rapidly removed by renal clearance. This “shortcoming” can be advantageous when used as a drug carrier for directing therapy to NMIBC. Here we develop a urinary drug-disposing (UDD) approach to improve NMIBC treatment. A 12-amino acid bio-inert peptide (Bdd) that can be exclusively eliminated via renal filtration was generated for delivering the microtubule inhibitor DM1 to NMIBC with minimal nonspecific accumulation in other organs. The UDD approach prolonged survival of mice bearing human bladder tumors. Unlike IT, the treatment was given noninvasively (intravenously). Furthermore, it was more effective at suppressing tumor growth than clinically used IT (mitomycin) and safer than free DM1. The application of this UDD approach to treat kidney tumors and deliver other drugs such as doxorubicin was also demonstrated. Overall, the rapid renal clearance of peptides can be exploited to direct cancer therapies to the urinary system.

Significance:
A noninvasive drug delivery approach that targets the urinary system overcomes the current barriers facing effective treatment of bladder cancer.
Differences in cerebral blood flow measurement using arterial spin labeling MRI between patients with moyamoya disease and patients with arteriosclerotic cerebrovascular disease
Authors: Ueda Yasuhiro , Tanaka Yoji , Hara Shoko , Inaji Motoki , Ishii Kenji , Maehara Taketoshi , Nariai Tadashi 
Published: January 2022

Background It is unclear whether the accuracy of arterial spin labeling (ASL) magnetic resonance imaging (MRI) is the same between moyamoya disease (MMD), which is known to have markedly elevated cerebral blood volume (CBV), and atherosclerotic intracranial arterial stenosis (AS), which has relatively less elevated CBV. Purpose To investigate how the differences in hemodynamics affect measurement of ASL-cerebral blood flow (CBF) using ASL for patients with MMD and AS. Material and Methods Fourteen MMD and ten AS patients were evaluated with ASL-MRI, magnetic resonance angiography (MRA), and 15O-gas positron emission computed tomography (PET). The regional CBF values of ASL using two post-labeling delays (PLDs; 1525 ms and 2525 ms) were compared with the PET-derived CBF, CBV, and mean transit time (MTT). Corresponding anterior circulation results were evaluated by flow territory map-based analysis. Results The correlation between the ASL-CBF values (2525 ms) and PET-CBF declined in the MMD group (r = 0.28; P < 0.01), while the AS group showed good correlation (r = 0.77; P < 0.01). In the MMD group, the ASL-CBF values (2525 ms) overestimated the PET-CBF values as the regional CBV values increased (r = 0.35; P < 0.01). When the regions of interest were divided into two subgroups according to the degree of arterial stenosis by MRA, the correlation coefficient between the ASL-CBF (2525 ms) and PET-CBF values improved (mild stenosis: r = 0.36; P = 0.06; severe stenosis: r = 0.51; P < 0.01). Conclusion The accuracy of CBF measurements using ASL-MRI differed between patients with MMD and AS. The prominent increase of CBV and the degree of arterial stenosis may have affected the accuracy of ASL-CBF in patients with MMD.
Characterization of cellulose nanofibril reinforced polybutylene succinate biocomposite
Authors: Saeed Usman , Taimoor Aqeel Ahmad , Rather Samiullah , Al- Zaitone Belal , Al-Turaif Hamad 
Published: January 2022

The environment friendly cellulose nanofibrils obtained from natural cellulose presents unique opportunity for developing a sustainable end product. The beneficial characteristics of cellulose nanofibrils are biocompatibility, low toxicity, suitable surface chemistry and useful physical properties. In the current study, the polybutylene succinate (PBS) with five levels of cellulose nanofibril (NFC) is being developed by using twin extruder. The differential scanning calorimeter results demonstrate that the addition of NFC has insignificant effect on the thermal behavior but it improves the tensile mechanical properties of thermoplastic PBS. The tensile strength reaches upto 30.81 MPA and elastic modulus increases upto 1.5 GPa with the addition of 10% cellulose nanofibril in polybutylene succinate. The rheological analysis shows that the complex viscosity η* of NFC/PBS presents the shear thinning behavior. The decrease in contact angle upto 70.7o with the addition of NFC in PBS matrix is related to its hydrophilic behavior which is also proved by the higher diffusion coefficient. Dynamic mechanical analysis was employed to characterize storage modulus G’ which increased by 1470 MPa due to the rise in PBS stiffness when 10% NFC was added. Finally, the interaction of cellulose nanofibrils in the polybutylene succinate matrix is evaluated by using fracture surface and X-ray photoelectron spectroscopy.
Necrotizing leg gangrene from invasive cutaneous Kaposi sarcoma, reversed by pegylated liposomal doxorubicin
Authors: Goff Catherine B. , Stapleton Ann , Aboulafia David M. , Dasanu Constantin A. 
Published: January 2022

Introduction Although rare, Kaposi sarcoma is the most common malignant neoplasm associated with human immunodeficiency virus (HIV) infection. Several agents have now been approved in the treatment of this malignancy and are used with varying degrees of success. Case report We present a unique case of a 64-year-old man with well-controlled HIV infection who developed necrotizing leg gangrene from invasive cutaneous Kaposi sarcoma. He responded very well to systemic chemotherapy, thereby avoiding limb amputation. Management and outcome Pegylated liposomal doxorubicin (PLD) at a dose of 20 mg/m2 every 3 weeks was utilized, with a near-complete response after six cycles of therapy. The patient continues to receive maintenance treatment with PLD. His HIV infection remains in excellent control, with a high-normal CD4 T-cell count. Periodic echocardiogram evaluations have not shown any decline in left ventricular ejection fraction (LVEF) over time. Conclusion Most patients with Kaposi sarcoma achieve partial responses to treatment with PLD. Our case illustrates that near complete and complete responses are possible with this agent, leading to potential limb salvage in necrotizing gangrene.
Lichen planopilaris-like eruption in chronic myeloid leukemia patient during treatment with nilotinib as second-line therapy
Authors: Gardellini Angelo , Guidotti Francesca , Zancanella Michelle , Maino Elena , Steffanoni Sara , Turrini Mauro 
Published: January 2022

Introduction Chronic myeloid leukemia (CML) is a malignant clonal disorder of hematopoietic stem cells characterized by a translocation of genetic material between chromosomes 9 and 22 resulting in the BCR-ABL fusion oncogene expression. Nilotinib is a potent second-generation tyrosine kinase inhibitor available as first line treatment. Among side effects QTc interval prolongation, pancreatitis, metabolic disorders and skin reactions are the most commonly seen. Case Report Here we describe a rare case of lichen planopilaris eruption that developed during therapy with nilotinib. Management & Outcome Nilotinib dosage was reduced together with introduction of hydroxychloroquine with progressive improvement of alopecia. Discussion Collaboration with dermatologist and nilotinib dose reduction allowed to continue the drug maintaining major molecular response and patient's quality of life.
Chemotherapy-induced neutropenia among breast Cancer patients in a tertiary care hospital: Risk and consequences
Authors: Joseph Anu , Joshua Julie Mariam , Mathews Santhosh M 
Published: January 2022

Study objective To identify the risk factors that may predispose breast cancer patients to Chemotherapy-induced neutropenia (CIN) and its associated complications for the years 2018 and 2020. CIN is an established complication of breast cancer treatment. Clinical Pharmacists can play an important role in the treatment of CIN through involvement in risk assessment to identify patients for oral antimicrobial therapy, drug therapy monitoring, and development of suitable guidelines or policies. Methodology A retrospective study was performed by collecting data of 72 breast cancer patients for the last two years from department of Medical Oncology in a tertiary care hospital. Results The overall occurrence of CIN was 59.7% in our study population. Out of 72 patients studied, 43 patients were found to be neutropenic. Using Pearson Chi square test, chemotherapy-induced neutropenia was associated with older age (over 60 y) ( p < 0.038), diabetes mellitus ( p < 0.050), tumour stage IIIa ( p < 0.024), AC ( p < 0.051) and taxane chemotherapy regimens ( p < 0.041). Febrile neutropenia occurred in 37.28% of patients and the incidence of infection-related mortality [severe septicaemia] was 3.38%. Conclusion The incorporation of clinical pharmacist must be brought into practice in our country for providing proper guidance to the patient on CIN and its complications. By identifying risk factors for neutropenia, the safe management of CIN may be possible in patients with breast cancer.
Comparison of microstructure and tensile behavior of hydroxyapatite-coated PEEK meshes and cellulose-based fabrics and mats
Authors: Naderi Armaghan , Palardy Genevieve 
Published: January 2022

Polymeric biomaterials, such as polyether ether ketone (PEEK) and cellulose, have been explored as scaffolds for bone tissue engineering in the past decade. In this study, microstructure and mechanical behavior of uncoated and hydroxyapatite (HA)-coated polymeric meshes, fabrics, and mats were investigated. Commercially available monofilament PEEK meshes, and cellulose fabrics and mats were selected, then coated with a customized low temperature sol–gel method (≤ 150°C). Adhesive HA coating consisting of HA, β-TCP, and CaO with nanorod structure was derived. After HA coating, porosity of substrates (except filter-paper cellulose mats) decreased by up to 43%, indicating effective coating. Both uncoated and HA-coated substrates’ degradation rate in phosphate-buffered saline decreased after day 3. This is a result of ion precipitation or calcium compounds formation, indicating potential stability in biofluids for an extended period of time. Regarding tensile test results, highest tensile strength and elongation at break were obtained for PEEK meshes (approximately 80 MPa and 35%, respectively), as a result of the bulk material properties. HA coating did not significantly affect the tensile properties of the specimens, except for cellulose mats with an initial porosity of 77% (tensile modulus increased by 270% and strength by 210%). The increase in tensile properties could be attributed to increased rigidity, resulting from the adhesion between HA coating and cellulose fibers. Overall, HA-coated cellulose mats and PEEK meshes show promise as customizable, flexible scaffolds for implant applications and bone regeneration for future work.
Cost Analysis of Providing Overtime to Current Nurses Versus Hiring a Dedicated Nurse for COVID-19 Management in a Processing Plant
Authors: Naylor Jennifer , Gillespie Gordon Lee , Betcher Cynthia , Orr C. Edward 
Published: January 2022

Background: U.S. meat and poultry processing workers experienced a disproportionate burden of COVID-19 illness following the declaration of the COVID-19 pandemic. Managing prevention and surveillance activities for COVID-19 prevention required additional work for occupational health nurses. The purpose of this project was to conduct a cost analysis for two staffing options to address the increased workload for occupational health nurses. Methods: An economic quality improvement design was used for this study. The project was performed at a meat and poultry processing plant with 1,800 employees and six occupational health nurses. Two staffing options were considered. Option 1 was to continue to pay current occupational health nurses overtime, and Option 2 was to hire a COVID-dedicated nurse to manage the increased workload. A cost analysis was conducted for wages per hour plus benefits at three time points: 3 months, 1 year, and 3 years. Findings: Costs for Option 1 (continuing overtime) at 3 months, 1 year, and 3 years were estimated at US$27,370, US$109,517, and US$328,550, respectively. Costs for Option 2 (hiring a COVID-dedicated nurse) at 3 months, 1 year, and 3 years were estimated at US$44,279, US$94,979, and US$230,179, respectively. Conclusions/Application to Practice: Hiring a dedicated COVID nurse would save the processing plant extensive salary costs by Year 3. Reducing overtime had the potential to decrease the COVID-19-related workload and potential experiences of fatigue and burnout in occupational health nurses.
Monthly migraine days, tablet utilization, and quality of life associated with Rimegepant – post hoc results from an open label safety study (BHV3000–201)
Authors: Johnston Karissa , Harris Linda , Powell Lauren , Popoff Evan , Coric Vladimir , L’Italien Gilbert , Schreiber Curtis P. 
Published: January 2022

Abstract
Background
The objective of this study was to describe patterns in monthly migraine days (MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures in patients treated as needed (PRN) with rimegepant 75 mg over 52-weeks.

Methods
Eligible subjects were adults with ≥1 year history of migraine and ≥ 6 MMD at baseline, who used rimegepant 75 mg up to once daily PRN (at their discretion) for up to 52-weeks in an open-label safety study (BHV3000–201; NCT03266588). Mean MMD were calculated at each 4-week period, along with mean monthly tablets taken. Migraine-specific quality of life (MSQv2) data were mapped to EQ-5D utilities and used to characterize HRQoL over time. A published network meta-analysis was used to characterize pain hours as well as time periods spent migraine free.

Results
One thousand forty four subjects were included in this post-hoc analysis. Overall mean MMD were 10.9 at baseline and decreased to 8.9 by week 52. Tablet use remained stable over the follow-up period. A total of 0.08 incremental QALYs were associated with rimegepant use.

Conclusion
For subjects with 6 or more MMD, acute treatment of migraine attacks with rimegepant 75 mg on a PRN basis over one-year of follow-up was found to be associated with reduced MMD frequency without an increase in monthly tablet utilization, and improved HRQoL. There was no evidence of medication-related increases in MMDs when rimegepant 75 mg was used as needed for the acute treatment of migraine over 52-weeks.

Trial registration
ClinicalTrials.gov identifier NCT03266588.
A truncated nuclear norm and graph-Laplacian regularized low-rank representation method for tumor clustering and gene selection
Authors: Liu Qi 
Published: January 2022

AbstractBackgroundClustering and feature selection act major roles in many communities. As a matrix factorization, Low-Rank Representation (LRR) has attracted lots of attentions in clustering and feature selection, but sometimes its performance is frustrated when the data samples are insufficient or contain a lot of noise.ResultsTo address this drawback, a novel LRR model named TGLRR is proposed by integrating the truncated nuclear norm with graph-Laplacian. Different from the nuclear norm minimizing all singular values, the truncated nuclear norm only minimizes some smallest singular values, which can dispel the harm of shrinkage of the leading singular values. Finally, an efficient algorithm based on Linearized Alternating Direction with Adaptive Penalty is applied to resolving the optimization problem.ConclusionsThe results show that the TGLRR method exceeds the existing state-of-the-art methods in aspect of tumor clustering and gene selection on integrated gene expression data.
First analyses of lysine succinylation proteome and overlap between succinylation and acetylation in Solenopsis invicta Buren (Hymenoptera: Formicidae)
Authors: Ye Jingwen , Li Jun 
Published: January 2022

Abstract
Background
Lysine succinylation (Ksu) exists in both eukaryotes and prokaryotes, and influences a variety of metabolism processes. However, little attention has been paid to Ksu in insects, especially the notorious invasive pest Solenopsis invicta.

Results
In this study, the first analyses of Ksu proteome and overlap between Ksu and lysine acetylation (Kac) in S. invicta were presented. 3753 succinylated sites in 893 succinylated proteins were tested. The dihydrolipoyl dehydrogenase, V-type proton ATPase subunit G, and tubulin alpha chain all had evolutionary conservatism among diverse ant or bee species. Immunoblotting validation showed that there were many Ksu protein bands with a wide range of molecular mass. In addition, 1230 sites in 439 proteins were highly overlapped between Ksu and Kac. 54.05% of Ksu proteins in cytoplasm were acetylated. The results demonstrated that Ksu may play a vital part in the allergization, redox metabolism, sugar, fat, and protein metabolism, energy production, immune response, and biosynthesis of various secondary metabolites.

Conclusions
Ksu and Kac were two ubiquitous protein post-translational modifications participated in a variety of biological processes. Our results may supply rich resources and a starting point for the molecular basic research of regulation on metabolic pathways and other biological processes by succinylation and acetylation.