bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of grey BP neural network model based on wavelet denoising to predict the residual settlement of goafs
Authors: Zhang Xiangdong , Li Wenliang , Zhang Xuefeng , Cai Guanjun , Meng Kejing , Shen Zhen 
Published: May 2022

Abstract
The residual settlement of goafs is a nonlinear process with time series. To study its settlement law and prediction model, we chose the Mentougou mining area in Beijing as a example. The wavelet threshold denoising method was used to optimize the measured data, and the Grey GM (1,1) and BP neural network models were combined in series. A grey BP neural network model based on wavelet denoising was proposed, the prediction accuracy of different models was calculated, and the prediction results were compared with the original data. The results showed that the prediction accuracy of the grey BP neural network combined model was higher than that of the single GM (1,1) model. Furthermore, the mean absolute percentage and root mean square errors of the grey BP neural network model after wavelet denoising were 0.35% and 16.05, respectively, both less than the errors of the combined prediction model using the original data. Thus, the combination model optimized by wavelet analysis had a high prediction accuracy, strong stability, and accorded with the law of change of measured data. It accurately reflected the goaf surface subsidence process, and therefore has a strong popularization and application value.
Rapid differentiation of SARS-CoV-2 variants on a nanotechnology enhanced DNA-chip
Authors: Dai Hongjie , Liu Ying , Yang Yang , Wang Guanghui , Hu Ruibin , Shao Pan-Lin , Tang Jiahu , Xu Ziyi , Liu Yan , Xiao Hongjun , Lv Jiahui , Yang Jingkai , Niu Dan , Meijie Tang , Yuan Jing , Zhang Bo 
Published: May 2022

Abstract
With the persistence of the COVID-19 pandemic caused primarily by constant viral mutations, rapid identification of different lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by large-scale screening at the point-of-care could be key to monitoring and assessing viral evolutions. Herein, we developed a Fluorescence Enhanced Microarray for Multiplex Analysis of Nucleic acids (FEMMAN) for detecting 8 SARS-CoV-2 variants simultaneously in ~ 3 hours without the need of RNA extraction, opening the possibility of point-of-care testing of multiple SARS-CoV-2 variants while reducing the cost significantly to ~ $ 7 per sample from ~ $100 by Next-Generation Sequencing (NGS). Combined with isothermal amplification, the multiplexed RNA assay achieved single-copy detection sensitivity and single nucleotide variant (SNV) distinction owing to the nanotechnology based plasmonic gold (pGOLD) near-infrared fluorescence enhancing platform. Probing 10 targets of three mutational hotspots in S gene, we differentiated 8 viral lineages (Wild type, Alpha, Beta, Gamma, Delta, Lambda, Mu, and Omicron) of SARS-CoV-2, validated using nasopharyngeal swabs obtained from 127 individuals, achieving a 100% sensitivity and 100% specificity in SARS-CoV-2 detection, and a 91.1% concordance with NGS in variant identification. The scalable, multiplexed FEMMAN assay could shift the paradigm of COVID-19 diagnostic and surveillance from positive/negative assessments to simultaneous lineage identification in large-scale screening, greatly facilitating the global monitoring of SARS-CoV-2 variants.
The Pyroptosis Related Genes Signature Predicts Prognosis and Immune Infiltration of Tumor microenvironment in Hepatocellular carcinoma
Authors: Fang Guoxu , Zhang Qinghua , Fan Jianhui , Ding Zongren , Fu Jun , Wu Yijun , Zeng Yongyi , Liu Jingfeng 
Published: May 2022

Abstract
Hepatocellular carcinoma (HCC) is a particularly heterogeneous tumor. It has a very poor prognosis. Pyroptosis has been demonstrated in recent years to be an inflammatory form of programmed cell death. However, the relationship between the expression of pyroptosis related genes (PRGs) and prognosis of HCC is still unclear. The development of a specific PRGs prognostic model is important if we want to improve therapeutic effect of tumor. In this study, we identified 42 PRGs that were differentially expressed between HCC and peripheral normal tissues and exhibited the mutation frequency, classification, the location of copy number variation (CNV) alteration and the CNV variation frequency of PRGs. Two clusters were distinguished by the consensus clustering analysis based on the 42 differentially expressed genes (DEGs). The result show that there were significant differences in clinical features (including T stage, grade, gender, stage) among different clusters. KM curve analysis show that cluster 1 had a better prognosis than cluster 2. The prognostic value of PRGs for survival was evaluated to construct a multigene signature using The Cancer Genome Atlas (TCGA) cohort. By applying the univariate analysis and multivariate analysis method, a 10-gene signature was built and all HCC patients in the TCGA cohort were divided into low-risk group and high-risk group. HCC patients in the high-risk group showed significantly lower survival possibilities than those in the low-risk group (P<0.001). Utilizing the median risk score from the TCGA cohort, HCC patients from Gene Expression Omnibus (GEO) cohort (GSE14520) were divided into two risk subgroups. The result showed that overall survival (OS) time was decreased in the high-risk group (P=0.027). Combined with the clinical characteristics, the risk score was found to be an independent factor for predicting the OS of HCC patients. Then, for evaluating the prognostic prediction value of the model, ROC curve and survival analysis were performed. Finally, we constructed a PRGs clinical characteristics nomogram to furtherly predict HCC patient survival probability. There were significant differences in immune cell infiltration, GSEA enrichment pathway, IC50 of chemotherapeutics, PRGs mutation frequency, GO and KEGG analysis between high-risk group and low-risk group. This work suggests PRGs signature plays a crucial role in HCC. The exploration may assist in identifying novel biomarkers and assist HCC patients in predicting their prognosis, clinical diagnosis, and management.
Estimating prevalence and predictors of musculoskeletal disorders in Tanzania – A pilot study
Authors: Yongolo Nateiya Mmeta , Halliday Jo , Bunn Christopher , Mtesha Benson , Kelly Clive , Krauth Stefanie J , Mwingwa Anthon , Biswaro Sanjura Mandela , Siebert Stefan , Kipengele Asia Hemed , Walker Richard , McIntosh Emma , Mmbaga Blandina Theophil 
Published: May 2022

Abstract
Background: Musculoskeletal (MSK) disorders account for 20% of all years lived with disability worldwide. There have been few prevalence studies of MSK disorders in Africa, and none published from Tanzania. Screening for MSK disorders is not routinely conducted in healthcare facilities and there are no registered rheumatology consultants in northern Tanzania. This pilot study aimed to provide an initial estimate of the community-based prevalence, and predictors, of MSK disorders and to assess the functional status and disability associated with MSK disorders. Methods: A cross-sectional pilot study was conducted in a single village in the Hai District Kilimanjaro region from March to June 2019, involving the administration of Gait, Arms, Legs, Spine (GALS) or paediatric GALS (pGALS) physical examinations during household and school visits. Individuals positive by GALS/pGALS screening were assessed by the regional examination of the musculoskeletal system (REMS) and the Modified Health Assessment Questionnaire (MHAQ) tools. Multivariable logistic regression analyses were used to understand the influence of demographic variables (age and sex), tribe and religion on GALS/pGALS, REMS and MHAQ outcomes. Results: A total of 1854 participants were enrolled. Of the 1172 individuals enrolled at the household level, 95 showed signs of MSK disorders during the GALS/pGALS examination (8.1%, 95% CI: 6.6 – 9.8) and 37 during the REMS examination (3.2%, 95% CI: 2.2 – 4.3), respectively. Among all 682 participants enrolled in schools, seven showed signs of MSK disorders during the GALS/pGALS examination (1.0%, 95% CI: 0.4 – 2.1) and three during the REMS examination (0.4%, 95% CI: 0.0 – 1.3), respectively. In the household enrolled population female gender and increasing age were significantly associated with GALS and REMS positive findings. Among the GALS positive individuals, increasing age was significantly associated with REMS positive status and increasing MHAQ scores, indicating worse function and greater disability. Conclusions: Our pilot study confirms the prevalence of MSK disorders in this study population and predictors of MSK disorders that are comparable to those seen elsewhere in the world. These pilot data can inform the design of future investigations of the determinants of MSK disorders and their impacts on health, livelihood, and well-being in Tanzania.
Nonlinear Analysis by Applying Best Approximation Method in p-Vector Spaces
Authors: YUAN George X. 
Published: May 2022

Abstract
It is known that the class of p-vector spaces (0 < p ≤ 1) is an important generalization of usual norm spaces with rich topological and geometrical structure, but the most tools and general principles with nature in nonlinearity have not been developed yet, the goal of this paper is to develop some useful tools in nonlinear analysisby applying the best approximation approach for the classes of 1-set contractive set-valued mappings in p-vectorspaces. In particular, we first develop the general fixed point theorems of condensing mappings which provideanswer to Schauder conjecture in 1930’s in the affirmative way under the setting of p-vector spaces. Then one bestapproximation result for upper semi-continuous and 1-set contractive set-valued is established, which is used as auseful tool to establish fixed points of non-self set-valued mappings with either inward or outward set conditions,and related various boundary conditions.
The Impact of Sublingual Atropine Eyedrops on Salivary Flow in 7–17-year-old Children During Routine Dental Procedures: a Randomized Controlled Trial
Authors: Samuel Shannon , Masih Shaila 
Published: May 2022

Abstract
ObjectiveSalivation is a double-edged sword. It is desired for its protective function to the oral structures but undesirable due to the need for isolation during dental procedures. Atropine sulphate drops are known to decrease salivary secretion due to their muscarinic antagonistic activity. The present study was undertaken to quantitatively assess decrease in salivary secretion in children post administration of atropine sulphate drops sublingually, during routine dental procedures.MethodsA total of 60 children between the ages of 7–17 years were divided into two groups. Case group was given atropine sulphate drops sublingually in a dose dependent manner and control group received distilled water in a similarly calculated dose. The stimulated and unstimulated salivary flow rate was quantitatively assessed at three-time intervals (0min, 60 min and 90mins) along with the heart rate and blood pressures.ResultsIt was found that the unstimulated salivary flow rates in case group dropped by 80.3% and stimulated flow rates reduced by 79.4% in 90 minutes. The study also showed that time of onset of action was within 60 minutes and effect lasted beyond 90 minutes.ConclusionsThe present study translated into proving that the dose administered was adequate to elicit the antisialogogue effect via chosen route in children and the duration of effect was adequate for routine dental procedures.Clinical RelevanceThe duration of effect of atropine drops, the route of administration, and reversibility of effect in children can be interpreted as adopting the said drug as an adjunct to conventional saliva control measures.Trial RegistrationThe present study bearing CTRI number – CTRI/2020/05/025447 was registered with the Clinical Trial Registry- India under ICMR – National Institute of Medical Statistics on 29/05/2020 prospectively.
Epidural and subdural interdural approach to the lateral wall of the cavernous sinus for preserving the laterocavernous sinus in trigeminal schwannoma
Authors: Adachi Kazuhide , Hasegawa Mituhiro , Hirose Yuichi 
Published: May 2022

Abstract
Evacuation of middle fossa trigeminal schwannomas (TS) warrants a subtemporal interdural approach through the lateral wall of the cavernous sinus (CS). The dura comprises the dura propria, which follows the trigeminal nerve and becomes the epineurium, and periosteal layer. The interdural approach involves peeling off the dura propria and exposing the epineural sheath. The venous route around the CS is often obstructed due to TS progression. The interdural approach based on venous route preservation remains to be discussed. The laterocavernous sinus (LCS) is formed in these layers, draining to either the medial or lateral route. In the lateral route, the LCS drains to the pterygoid plexus via the middle cranial fossa foramen. Exposure of the interdural space disturbs the lateral route’s venous flow. We describe an operative strategy for venous route preservation in the TS via the LCS lateral route. The venous route can be preserved by peeling off the dura propria from the posterior end of the foramen ovale short of the venous drainage route to the pterygoid plexus epidurally and then cutting from the middle cranial fossa dura posterior to the venous route subdurally to the exposed interdural space. This technique helps in avoiding postoperative venous complications.
The Association of Genitourinary Cancer Among Patients with Gastrointestinal Stromal Tumor: A Unique Pattern in a Tertiary Care Saudi Cohort.
Authors: Seyam Raouf , Chaer Kenan Abou , Abouelkhair Ahmed , Almouh Arwa , Alzahrani Othman , Alghafees Mohammad , Alhamidi Razan A. , Al-Gonaim Ali , Al-Hussain Turki , Amin Tarek Mahmoud , Altaweel Waleed 
Published: May 2022

Abstract
Purpose
The gastrointestinal tract's most commonly occurring primary mesenchymal tumor is the gastrointestinal stromal tumor (GIST). However, few cases worldwide were reported associated with renal cell carcinoma (RCC). Therefore, we aimed to identify the association of genitourinary tumors in patients with GIST in our tertiary care hospital in Saudi Arabia.
Methods
We identified all patients in the pathology department database with the diagnosis of GIST. We excluded duplicate and recurrent cases. We examined patients’ files for the presence of RCC, adrenal tumors, or other genitourinary cancer.
Results
From 2003 to 2022, 170 patients had a histopathologic diagnosis of primary GIST, 100 men and 70 women, median age of 63 (± 15.5) years at the time of diagnosis. The site of primary GIST was gastric 103, small bowel 43, mesenteric 5, omentum/peritoneum 7, abdomen 4, isolated adrenal 1, and other 7. Eight patients had associated genitourinary cancer. Three patients had RCC (two clear cell RCC and one radiologic diagnosis only), three had adrenal tumors (one adrenal carcinoma, one an isolated adrenal GIST and one pheochromocytoma), and two had a tumor invading the urinary bladder. Although the cohort included 63 men aged 60 years old or above (median 71 ± 8.7 years, range 60–94), none demonstrated clinical prostatic carcinoma.
Conclusion
We report the rare association between GIST tumors and primary genitourinary cancer, mainly RCC and adrenal tumors. Also, we identified a secondary invasion of the urinary bladder. Unlike the reported series, none of the older male patients had clinical prostate cancer.
Selenium nanoparticles reduce cardiomyocyte apoptosis in Ascites Syndrome in Broiler Chickens via the ATF6-DR5 signaling pathway
Authors: Liu xin , Yang Xiaoqi , KYEIN SAN LOON , Fu Yang , Liu Jiaqi , Peng Yuxuan , Zhang Jiabin , Zhang Mengdi , Zhou Donghai 
Published: May 2022

Abstract
Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well-documented that Myocardial hypertrophy and failure is one of the critical mechanisms in broiler ascites syndrome, and preventing cardiac hypertrophy and failure to cardioprotection may be one of the targets for lowering the incidence of broiler ascites syndrome. Nano-selenium has received a lot of attention in the biomedical field in recent years due to its unique physicochemical properties and potential applications in drug development and targeted therapy. The antioxidant capabilities of nano-selenium have been demonstrated to inhibit apoptosis. To investigate the impact of nano-selenium on broiler chicken heart injury caused by broiler ascites syndrome, we created a broiler chicken cardiomyocyte apoptosis model and a broiler chicken ascites syndrome model. Pretreatment of broiler cardiomyocytes with nano-selenium reduced oxidative stress and apoptosis caused by hydrogen peroxide, according to our findings. Furthermore, nano-selenium supplementation with broiler chickens' diets that inactivated the endoplasmic reticulum stress signaling system (ATF6-DR5). The current study sought to demonstrate that nano-selenium protects injured myocardium in a broiler ascites model, and the proposed mechanism is linked to the ATF6-DR5 signaling pathway, opening up new avenues for medication development to prevent and treat broiler ascites disease.
Long-COVID in Scotland Study: a nationwide, population cohort study
Authors: Pell Jill , Hastie Claire , Lowe David , McAuley Andrew , Winter Andrew , Mills Nicholas , Black Corri , Scott Janet , O'Donnell Catherine , Blane David , Browne Susan , Ibbotson Tracy 
Published: May 2022

Abstract
BACKGROUNDWith increasing numbers of people infected with SARS-CoV-2, a better understanding of long-COVID is required to inform health and social care support.METHODSA nationwide, ambidirectional, population cohort was constructed of adults in Scotland with a positive SARS-CoV-2 PCR test from April 2020 to May 2021 and a matched, never infected comparison group. Recovery status, symptoms, quality of life, impaired daily activities, hospitalization and death were ascertained via repeated self-completed questionnaires, at 6, 12 and 18-months follow-up, and linkage to hospitalization and death records.RESULTSThe cohort comprised 31,486 symptomatic and 1,795 asymptomatic infected individuals, and 62,957 never infected individuals. Of the former, 1,856 (6%) had not recovered and 13,350 (42%) only partially. Lack of recovery was associated with severe (hospitalized) infection, older age, female sex, deprivation, respiratory disease, depression and multimorbidity. Twenty-four persistent symptoms were independently associated with previous infection including breathlessness (OR 3.44, 95% CI 3.29–3.59), palpitations (OR 2.51, OR 2.37–2.67), chest pain (OR 2.10, 95% CI 1.97–2.24), and confusion (OR 2.93, 95% CI 2.78–3.08). Pre-infection vaccination was associated with reduced risk of seven symptoms. Previous symptomatic infection was also associated with poorer quality of life (EQ-5D median 75 vs 80, p < 0.001) and impairment across all daily activities. Asymptomatic infection was not associated with adverse outcomes.CONCLUSIONSThe sequelae of SARS-CoV-2 infection are wide-ranging and not explained by confounding. The risk of long-COVID is greater following severe infections requiring hospitalization and absent following asymptomatic infection, whilst pre-infection vaccination may be protective.
Exact solutions of Fractional Maxwell hybrid nanofluid flow model using Integral transforms
Authors: Elkott Ibrahim , Latif M.S. Abdel , El-Lalla I. L. , Kader A. H. Abdel 
Published: May 2022

Abstract
In this paper, we obtain exact solutions of a system of fractional partial differential equations (FPDEs) which describe natural convection heat transfer of a specific engine oil in oscillating vertical cylinder. The closed form solutions for the velocity and temperature profiles are obtained using Laplace and finite Hankel transforms. A closed form formula for the Nusselt number is obtained. The effects of the Prandtl number and the order of the fractional derivative on the temperature profile and the Nusselt number are discussed using some figures. The change in the velocity profile with the Prandtl number, the Grashof number, and the order of the fractional derivative is investigated.
Changes in pain during a depressive episode and relationship to cytokine levels in Major Depressive Disorder
Authors: Dahl Johan , Ormstad Heidi , Aass Hans Christian Dalsbotten , Malt Ulrik Fredrik , de Ole A. Andreassen 
Published: May 2022

Abstract
Background
Depressed patients have an increased incidence of pain. A pathophysiological connection between depression and pain is still not revealed. Immunological activation has been found in both depression and pain. There are few studies of pain and immune activation in patients with depression, without inflammatory and autoimmune disorders
Methods
This is a naturalistic follow-up study of 50 patients with a major depressive disorder (MDD) depressive episode, without any inflammatory or autoimmune conditions. We have previously reported on the relationship between depression and cytokine levels. In this study we obtained data of depression, pain and cytokine levels before and after 12 weeks of depression treatment. All patients were medication-free at inclusion.
Results
At inclusion three out of four patients experienced pain, and the pain scores correlated with the depression scores. After treatment, as depression was relieved, the pain scores dropped significantly and were no longer correlated to the depression scores. There were no correlations between pain scores and cytokine levels. Pain level at inclusion did not correlate with depression treatment outcome.
Conclusion
Our findings indicate that pain is a feature of depression. Pain levels and cytokine values didn`t correlate. Pain at inclusion did not predict depression treatment outcome.