bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Investigation on P-Y Method of Group Piles under Static and Dynamic Loads
Authors: Timurağaoğlu Mehmet ömer , Fahjan Yasin , Doğangün Adem 
Published: June 2022

Abstract
The present study aims at scrutinizing the static and dynamic behavior of pile-soil interaction in the context of p-y method using finite element analysis. For this purpose, a series of static and dynamic analyses are carried out for single pile, 2x2 and 3x3 group piles in homogeneous clayey soil. In the analysis, the nonlinear behavior of soil is taken into account using a kinematic hardening model, while piles are modeled as elastic. The soil model parameters are calibrated using experimental modulus degradation and damping curves. The pile-soil interface is modeled considering normal and shear behavior to account for separation and sliding between soil and pile elements. In the static analyses, variation of pile moments and displacements with depth and the back-calculated p-y curves are evaluated. The soil resistance is directly obtained by extracting the shear and normal forces of the nodes in a pile at any depth. The p-multipliers for 2x2 and 3x3 group piles are calculated and compared with that of the experiments. The variation of p-multipliers with depth and lateral displacement is also evaluated. In dynamic analyses, first, site response analyses are carried out and validated against one-dimensional results under different loading frequencies. Infinite elements are applied at the boundaries to provide non-reflective boundaries. Later, single, 2x2 and 3x3 group pile analyses are executed. The influence of loading amplitude and frequency on the response are investigated using moment-depth and displacement-depth relationships. Dynamic p-y curves are back-calculated and the results are deeply assessed by comparing with static curves.
Insights into the mechanism of inhibition of bone morphogenetic protein-1 (BMP-1) by the secreted frizzled related protein Sizzled
Authors: Sharma Urvashi , Goff Sandrine Vadon-Le , Harlos Karl , Zhao Yuguang , Mariano Natacha , Bijakowski Cecile , Bourhis Jean-Marie , Moali Catherine , Hulmes David J.S. , AGHAJARI NUSHIN BANU 
Published: June 2022

Abstract
Sizzled (Szl) is both a secreted frizzled related protein (sFRP) and a naturally occurring inhibitor of the zinc metalloproteinase bone morphogenetic protein-1 (BMP-1), a key regulator of extracellular matrix assembly and growth factor activation. Here we present a new crystal structure for Szl which differs from that previously reported by a large scale (90°) hinge rotation between its cysteine-rich and netrin-like domains. We also present results of a molecular docking analysis showing interactions likely to be involved in the inhibition of BMP-1 activity by Szl. When compared with known structures of BMP-1 in complex with small molecule inhibitors, this reveals features that may be helpful in the design of new inhibitors to prevent the excessive accumulation of extracellular matrix that is the hallmark of fibrotic diseases.
Novel green sulfated-PWA supported on MCM-41 coated NiFe 2 O 4 MNPs for xanthene and coumarin synthesis
Authors: El-Yazeed W. S. Abo , Hayes O. R. , Ahmed Awad I. 
Published: June 2022

Abstract
From an environmental and economic point of view, we focused on the preparation of simple catalysts with many advantages such as simple isolation, easy preparation, high stability, and well catalytic activity. Here, we prepared MCM-41 coated NiFe2O4 magnetic nanoparticles and modified their surface with phosphotungestic acid (PWA) and then sulfate. We tested the catalysts' efficiency and reuse towards the formation of xanthene and coumarin derivatives. They can be easily recovered by a simple magnet from the reaction mixture and reused up to several runs without a high decrease in the catalytic activity. The samples have been characterized by SEM, TEM, FT-IR, XRD, VSM, and XPS. XPS indicated the presence of the inverse-cubic spinel phase of NiFe2O4 and the contribution of Fe(III) − O and Ni(II) − O bonds in tetrahedral (Th) and octahedral (Oh) sites. The results indicated the good dispersion of sulfate and PWA nanoparticles on the surface and inside NF-MCM-41 which play an important role in increasing the acidity and activity of the catalyst towards the synthesis of xanthene and coumarin derivatives. The catalyst 20S-W/NF-MCM-41-II reveals the highest acidity (Ei=586.3 mV) and yields 93.92% 14-aryl-14H-dibenzo[a, j]xanthene and 78.32% 7-hydroxy-4-methyl coumarin.
16S rRNA Survey Reveals the Potential of Tongue Coating Microbiota in Distinguishing Patients with Chronic Heart Failure from Healthy Controls
Authors: Yuan Tianhui , Ye Xing , Jiang Xiaotao , Li Zhifang , Wang Yan , Yang Zhongqi , Fang Hongcheng , Xian Shaoxiang 
Published: June 2022

Abstract
Background: Tongue diagnosis, as a practical diagnostic approach of traditional Chinese medicine (TCM), reflects physiological functions and pathological conditions in human body. Different features are observed in tongue images including tongue coating and tongue color between chronic heart failure (CHF) patients and healthy controls (HCs), which probably results from different dominant tongue coating microbiota. In this study, we aim to investigate the differences of tongue coating microbiota between CHF patients and HCs, hoping to discover valuable novel biomarkers for CHF. In this study, altogether 60 CHF patients and 30 HCs were enrolled. Oral swabs collected tongue coating samples, then the 16S rRNA survey was conducted to analyze tongue coating microbiota.Results: In total, 42 CHF patients with New York Heart Association (NYHA) functional class II-IV and 28 HCs were recruited. The alpha diversity was higher in HCs, while beta diversity was higher in CHF patients. At phylum level, the relative abundance of Proteobacteria was significantly higher in CHF patients (P<0.05) while TM7 was higher in HCs (P<0.05). At family level, in CHF patients, Neisseriaceae, Flavobacteriaceae, Aerococcaceae, Bacteroidaceae, Bacteroidales_incertae_sedis, Comamonadaceae and Lactobacillaceae were more abundant whereas the abundance of Actinomycetaceae, Clostridiales_Incertae_Sedis_XIII, Erysipelotrichaceae, Eubacteriaceae, Peptococcaceae_1, Peptostreptococcaceae, Prevotellaceae and TM7_family_incertae_sedis were lower. Compared with HCs, eight microbes with higher abundance in CHF patients including Abiotrophia, Anaeroglobus, Bacteroides, Butyrivibrio, Capnocytophaga, Lactobacillus, Neisseria and Phocaeicola. The other 11 microbes were less abundant in CHF patients comprised of Anaerovorax, Eubacterium, Kingella, Mogibacterium, Murdochiella, Peptococcus, Peptostreptococcus, Simonsiella, Solobacterium and TM7_genus_incertae_sedis. Notably, 14 genera of microbes could distinguish CHF patients from HCs, and the AUC of their combined diagnosis was 98.13% (95% confidential interval as 95.77%-100.00%). In accordance to Spearman’s correlation, Eubacterium, Solobacterium and Rhizobium were core genera and the abundance of Eubacterium and Solobacterium exhibited downward trends as NYHA class increases.Conclusion: This study preliminary revealed the microbiota dysbiosis of the tongue coating in CHF patients and identified potential biomarkers for CHF diagnosis and management.
Identification of a Novel ceRNA Network Related to Prognosis and Immunity in HNSCC Based on Integrated Bioinformatic Investigation
Authors: Liu Hongbo , Hei Guoli , Zhang Lu , Jiang Yanxia , Lu Haijun 
Published: June 2022

Abstract
Head and neck squamous cell carcinoma (HNSCC) is characterized by an immunosuppressive environment and necessitates the development of new immunotherapy response predictors. The study aimed to build a prognosis-related competing endogenous RNA (ceRNA) network based on immune-related genes (IRGs) and analyze its immunological signatures. Differentially expressed IRGs were identified by bioinformatics analysis with Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and ImmPort databases. Finally, via upstream prognosis-related microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) prediction and co-expression analysis, we built an immune-related ceRNA network (LINC00052/hsa-miR-148a-3p/PLAU) related to HNSCC patient prognosis. CIBERSORT analysis demonstrated that there were substantial differences in 11 infiltrating immune cells in HNSCC, and PLAU was closely correlated with 10 type cells, including T cells CD8+ (R = − 0.329), T cells follicular helper (R = -0.342) and macrophage M0 (R = 0.278). Methylation and Tumor Immune Dysfunction and Exclusion (TIDE) analyses revealed that PLAU upregulation was most likely caused by hypomethylation and that high PLAU expression may be associated with tumor immune evasion in HNSCC.
Risk Factors for Early Neurological Deterioration in Acute Isolated Pontine Infarction Without Any Causative Artery Stenosis
Authors: Liu Yinglin , Peng Hongmei , Wang Jian , He Lanying , Xu Jinghan , Zheng Min , Xu Yao , Xu Fan 
Published: June 2022

Abstract
Background
This study aimed to investigate the risk predictors for early neurological deterioration (END) in isolated acute pontine infarction (API) without any causative artery stenosis.
Methods
In this retrospective study, patients with isolated API within 72 h of symptom onset were enrolled between October 2017 and December 2021. END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) score ≥ 2 points within the first week postadmission. Patients were divided into the END and the non-END groups. Multiple logistic regression analysis was used to evaluate independent predictors of END in patients with isolated API.
Results
A total of 153 patients were included in the final study (62 females; mean age, 67.27 ± 11.35 years), of whom 28.7% (47 of 153) experienced END. Multiple logistic regression analyses showed that infarct volume (adjusted odds ratio [aOR], 1.003; 95% CI, 1.001–1.005; P = 0.002) and basilar artery branch disease (BABD) (aOR, 3.388; 95% CI, 1.102–10.417; P = 0.033) were associated with END. The combined ROC analysis of the infarct volume and BABD for predicting END showed that the sensitivity and specificity were 80.9% and 72.6%, respectively.
Conclusion
BABD and infarct volume were associated with END in acute isolated pontine infarction and may be useful prognostic factors for neurological progression.
Cerebellum and mental state recognition: a transcranial direct current stimulation study in healthy subjects
Authors: Clausi Silvia , Lupo Michela , Funghi Giulia , Mammone Alessia , Leggio Maria 
Published: June 2022

Abstract
Increasing evidence from neuroimaging and clinical studies demonstrated cerebellar involvement in social cognition components, including the mentalizing process. The aim of this study was to apply transcranial direct current stimulation (tDCS) to modulate cerebellar excitability to investigate the role the cerebellum plays in mental state recognition. Forty-eight healthy subjects were randomly assigned to different groups in which anodal, cathodal, or sham tDCS (2 mA for 20 min) was delivered centring the electrode on the vermis to stimulate the posterior portion of the cerebellum. The ability to attribute mental states to others was tested before and after tDCS using a digital version of the 'Reading the Mind in the Eyes test', which includes visual perceptive and motor stimuli as control conditions. Correct response and reaction times (RT) were recorded. Results revealed a significant reduction in RTs between the baseline and post-stimulation sessions after the cerebellar anodal tDCS only for mental state stimuli, whereas no significant effect was found in the cathodal or sham conditions or for visual perceptive and motor stimuli. Overall, our study suggests that cerebellar anodal tDCS might selectively improve mental state recognition and constitute an effective strategy to positively modulate the mentalizing process.
Impact of Nosema ceranae infection on sucrose solution consumption, midgut epithelial cell structure, and lifespan of Apis cerana cerana workers
Authors: Long Qi , Sun Minghui , Fan Xiaoxue , Zhang Wende , Zhou Dingding , Hu Ying , Wang Zixin , Zhang Kaiyao , Zhao Haodong , Song Yuemei , Fu Zhongmin , Chen Dafu , Guo Rui 
Published: June 2022

Abstract
Apis cerana is the original host for N. ceranae, and the impact of Nosema ceranae infection on A. cerana is largely unknown. In this study, workers of Apis cerana cerana were inoculated with N. ceranae spores. and the effects on the microsporidian spore load, host sucrose solution consumption, midgut epithelial cell structure, and lifespan were investigated. Spore counting suggested that the spore load in the host midguts decreased from 1 to 2 days post inoculation (dpi), while it increased from 2 to 13 dpi. No statistically significant difference in workers’ sucrose solution consumption was detected between N. ceranae-inoculated and un-inoculated groups. Microscopic observation showed darkly stained microsporidia in the midgut epithelial cells of N. ceranae-inoculated workers from 7 to 10 dpi. Additionally, the boundary of N. ceranae-inoculated host epithelial cells was blurred, the nucleus had almost disappeared, and the nucleic acid substance was diffused, whereas the boundary of un-inoculated midgut epithelial cells remained intact and the darkly stained nucleus was clear. The survival rates of workers in both N. ceranae-inoculated groups and un-inoculated groups started to decrease at 5 dpi. Additionally, the survival rate of workers in N. ceranae-inoculated groups was nearly always lower than that in un-inoculated groups, and there was a significant difference between these two groups from 11 to 20 dpi. These results demonstrate that the spore load of N. ceranae continuously elevated with microsporidian proliferation, causing damage to the midgut epithelial cell structure and shortening the host’s lifespan. Our findings offer a solid basis for exploring the molecular mechanism underlying N. ceranae infection and N. ceranae–A. cerana interaction.
Evaluation of the thermal performance of traditional courtyard houses in a warm humid climate: Colima, Mexico
Authors: Toris-Guitron M. Gabriela , Esparza-López Carlos J. , Luna-León Aníbal , Pozo Carlos Escobar-del 
Published: June 2022

Abstract
With the recent need to decrease the use of energy and promote indoor thermal comfort in overheating conditions, attention has been drowned on the passive cooling function of courtyards. This paper aims to determine the effect of proportions and orientations of courtyards on the indoor thermal performance of traditional houses in a warm, humid region so that this could guide further improvement and reinterpretation of this building type. The results of this parametric study were obtained through computer simulations of different cases. Rather than promote passive cooling in the building, the findings suggest that the courtyard greatly increases solar heat gain, raising the temperature during the day. Higher solar heat gains and ventilation rates were observed in the courtyard cases with greater width and length. Nevertheless, this does not cause important differences in the average operative temperature of the entire building between the cases. As for orientation, lower heat gains were obtained in courtyards with the long axis-oriented east to west. Regardless of the cases, the study finally emphasizes the importance of the inhabitants controlling the opening of windows in the enclosed rooms since this could decrease the temperature by 1.1ºC from night to the early morning (23.00 hrs to 11.00hrs) and thus influence its thermal comfort. Conversely, opening the windows outside that time-lapse could cause an increase in temperature and more hours above the upper comfort limit.
Pediatric Open-globe Injuries: Clinical Characteristics and Outcomes of Repair in a Tertiary Center in Istanbul, Turkey
Authors: Kabakcı Aslı Kırmacı , Atik Burcu Kemer , Livan Elif Hazal , Ocak Serap Yurttaşer , Elçioğlu Mustafa Nuri 
Published: June 2022

Abstract
PURPOSE: Open-globe injury is defined as trauma causing a full-thickness defect of the eyewall, with reported ratios of 28.9-49.7% occurring in the pediatric age group of all the injuries. Eye injuries account for 8-14% of all injuries in pediatric patients. Our purpose in this retrospective study was to evaluate the epidemiology, etiology, and outcomes of pediatric open-glob injury patients diagnosed and treated at a tertiary medical center in Istanbul, Turkey; with an aim of making contribution to the data in order to establish specific preventative guidelines for ocular trauma within the pediatric population.METHODS: The medical records of 56 patients ≤18 years old who underwent primary open-globe injury repair at Prof.Dr.Cemil Tascioglu State Hospital from January 2016 to January 2021 were retrospectively reviewed. RESULTS: The majority of the injuries took place at home (35 cases, 62.5%).The most common traumatizing object was knife in 10.7% of the cases, followed by fork in 8.9%.CONCLUSION: In conclusion, our study demonstrated that the visual acuity at presentation and the presence of lens injury are prognostic factors for open-globe injuries in pediatric age group.These findings can be useful in terms of predicting the prognosis and managing the expectation of the children with open-globe injury and their parents. However, we believe that adoption of appropriate protective measures in order to avoid unnecessary injuries are far more effective in terms of preventing visual impairment than advancements in any kind of treatment or management strategies after the injury.
Changes in Developmental-Behavioral Pediatric Referral Trends from a non-Western Country during the Covid-19 Pandemic
Authors: Omercioglu Emel , Yesil Ayse Mete , Avcı Hanife , Ozmert Elif N. 
Published: June 2022

Abstract
Objectives
The global spread of COVID-19 and associated policies have caused negative factors at the level of children, families, and services, resulting in physical, mental, and developmental issues in children, as well as limited access to healthcare. We evaluated the referral numbers, sources, and trends of a developmental-behavioral pediatrics (DBP) department in Turkey as a Eurasian country, as well as the effects of the COVID-19 pandemic on referral variables.
Methods
This longitudinal observational research examined patient referral data to Hacettepe University Developmental-Behavioral Pediatrics Department (HUDPD) between 2014 and 2021. We analyzed the changes in the number of referrals over time in 3-month intervals using negative binomial regression models (NBR). The impact of the COVID-19 pandemic on referral reasons was evaluated.
Results
The overall number of referrals increased by 1.040-fold [95% confidence interval (CI) 1.015–1.067] per year. There was a 1.070 (95% CI: 1.033–1.110)-fold increase per year before the pandemic, and a 1.077 (95% CI: 0.933–1.24)-fold increase afterward. Referrals for perinatal-neonatal risks were 1.359 (95% CI: 1.269–1.456) times higher than in the pre-pandemic period, and those for suspected autism were 1.209 (95% CI: 0.987–1.478) times higher.
Conclusion
Although it is encouraging that our referral trends have improved in the 1.5 years since the COVID-19 pandemic, it is thought that health service constraints caused a considerable increase in prenatal risk and suspicion of autism referrals following the pandemic. Improvement and innovation in healthcare systems to prevent the long-term detrimental impacts of periodic interruptions in healthcare on children's development and behavior is needed.
Single and joined behaviour of circulating biomarkers in high-fit and low-fit healthy females
Authors: Janssen Joëlle J.E. , Lagerwaard Bart , Nieuwenhuizen Arie G. , Escoté Xavier , Canela Núria , Bas Josep M. del , de Boer Vincent C.J. , Keijer Jaap 
Published: June 2022

Abstract
Background
Biomarkers are important in the assessment of health and disease but are poorly studied in healthy individuals. Especially responses of biomarkers in the systemic circulation to longer-term and short-term lifestyle interventions are incompletely understood, neither is their relative response to each other. This study investigated how single biomarkers, functional biomarker categories and total biomarker profiles respond to a difference in longer-term physical activity and recent exercise in healthy individuals.
Methods
A total of 102 biomarkers were analysed in serum or plasma samples from 30 young, healthy, female adults divided into a high-fit (V̇O2peak ≥ 47 mL/kg/min, N = 15) and low-fit (V̇O2peak ≤ 37 mL/kg/min, N = 15) group, at baseline and overnight after a single bout of exercise (60 min, 70% V̇O2peak).
Results
Total biomarker profiles were similar between high-fit and low-fit females, with only significantly lower leptin levels in high-fit females (adj.Pgroup = 0.076). Recent exercise significantly affected several single biomarkers related to inflammation and lipid metabolism, and adiponectin (all adj.Pexercise < 0.01). Furthermore, functional biomarker categories corresponded to biomarker clusters generated via hierarchical clustering models.
Conclusion
This study provides insight in the single and joined behaviour of circulating biomarkers in healthy females and identified functional biomarker categories that may be used for characterization of human health physiology.
Trial registration:
Registered in the Dutch trial register (ref.no. NL7891) on 2019-07-23.
A new approach for monitoring crops using remote sensing
Authors: Baradaran Amir Abbas , Tavazoei Mohammad Saleh 
Published: June 2022

Abstract
Due to different climatic conditions and the high cost of devices, monitoring plant growth is complex and costly. Remote sensing of agricultural lands, especially on a large scale, using satellite imagery, is more appropriate than hardware equipment such as sensors. One of the main challenges in plant growth is the rate of plant evapotranspiration discussed in the FAO-56 paper. The rate of plant evapotranspiration in the initial, development, and late growth stages is an important issue. Factors such as irrigation method, surface albedo, height above sea level, aerodynamic conditions, leaf and stomata characteristics between plants, and soil texture, have made it difficult to study plant growth from placement to harvest. In this research using Landsat 8 satellite imagery and vegetation indices, we present an approach in which exist several important indicators for sensing plant growth, determining soil texture and moisture, land slope, and improving cloud effects in remote sensing. The water required by the plant at different stages of its growth and the equations in FAO-56 paper can be estimated and improved using the indices. We have used cubic spline interpolation, Pearson correlation coefficient, explanation coefficient (R2), Root Mean Square Error (RMSE), Mean Absolute Deviation (MAD), and the Mean Standard Error (MSE) to evaluate and compare the accuracy of each index. Finally, the correlation equation of each index is calculated with its actual values. We have also used hypothesis and regression analysis testing to prove efficiency and predict crop behavior.