bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atherosis of Trophoblast Type: A Specific Form of Decidual Vasculopathy Distinct From Atherosis of Macrophage Type
Authors: Zhang Peilin , Baergen Rebecca 
Published: March 2022

Context.—
There are 3 types of decidual vasculopathy, namely, acute atherosis, fibrinoid medial necrosis, and mural arterial hypertrophy. Persistence of vascular trophoblasts is also known to be related to maternal vascular malperfusion, but detailed study is lacking.

Objective.—
To define atherosis of trophoblast type and distinguish it from atherosis of macrophage type with clinical significance.

Design.—
A total of 1322 placentas from 2021 were collected with clinical, neonatal, and placental information, and routine placental pathology examination was performed. Decidual vasculopathy was classified on the basis of the new classification scheme including atherosis of macrophage type, atherosis of trophoblast type, fibrinoid medial necrosis, mural arterial hypertrophy, and mixed-type vasculopathy. The significance of these morphologic changes was examined on the basis of clinical, neonatal, and placental pathology features.

Results.—
Decidual vasculopathy is classified as classic type, mural hypertrophy, and mixed type. Classic-type vasculopathy is further separated as atherosis and fibrinoid medial necrosis. Atherosis is defined as atherosis of macrophage type and atherosis of trophoblast type. Each category of decidual vasculopathy was evaluated in association with maternal, neonatal, and placental pathologic findings. Atherosis of macrophage type and mixed-type vasculopathy showed statistically significant association with preeclampsia/pregnancy-induced hypertension, low birth weight, and low placental weight. Atherosis of trophoblast type was associated with lower placental weight but not with other specific clinical features. Neonates of female sex were associated with mural arterial hypertrophy.

Conclusions.—
Atherosis of trophoblast type is a distinct pathologic feature in late pregnancy, and it is associated with lower placental weight. New classification of decidual vasculopathy helps with better stratification and categorization of placental maternal vascular abnormalities of late pregnancy.
Association of Asthma Exacerbation Risk and Physician Time Expenditure With Provision of Asthma Action Plans and Education for Pediatric Patients
Authors: Afolabi Titilola , Fairman Kathleen A. 
Published: March 2022

OBJECTIVE
To provide information about factors underlying provision of asthma action plans (AAPs) to a minority of pediatric patients with asthma, assess whether risk of exacerbation acts on provision of AAP and asthma education directly, suggesting targeting to highest-risk patients, or indirectly by influencing physician-patient interaction time.

METHODS
This study was a retrospective cross-sectional analysis of a nationally representative sample of physician office visits that consisted of patients aged 2 to 18 years with asthma. Exacerbation risk comprised proxy indicators of control and severity. Direct and time-mediated effects of exacerbation risk on provision of AAP and education were calculated from logistic regression models.

RESULTS
Asthma action plans were provided in 14.3% of visits, education in 23.9%. Total direct effects of exacerbation risk (ORs = 3.88–4.69) far exceeded indirect, time-mediated effects (both ORs = 1.03) on AAPs. Direct effects on education were similar but smaller. After adjusting for risk, physician time expenditure of ≥30 minutes was associated with nearly doubled odds of providing AAP or education (ORs = 1.90–1.99). Visits that included allied health professionals alongside physician care were significantly associated with all 4 outcomes in multivariate analyses (ORs = 3.06–5.28).

CONCLUSIONS
Exacerbation risk has a strong, direct association with AAP provision in pediatric asthma, even controlling for physician time expenditure. Provision of AAP and education to pediatric patients with asthma may be facilitated by increasing available time for office visits and involving allied health professionals.
SÍNDROME DE MARFAN: UM RELATO DE CASO CLÍNICO
Authors: Da Luz Síntique Priscila Alves , Torregrossa Vinícius Rabelo , Sarmento Viviane Almeida , Vieira Vinícius da Costa , Lamberti Patrícia Leite Ribeiro 
Published: March 2022

Objetivo: Apresentar um relato de caso clínico de um paciente portador da Síndrome de Marfan (SM). Descriçãodocaso: Paciente do sexo masculino, apresentou-se com queixa de diarréia crônica há pelo menos dois anos, dor torácica, precordial e retro-orbitária. Durante a anamnese relatou ser portador da SM, sendo observados ao exame físico, sinais que corroboram para a confirmação do diagnóstico quanto à síndrome. São estes: tórax ca- renado, alongamento vertical facial e aracnodactilia. Ao exame intrabucal percebeu-se alterações bucais comuns a pacientes portadores da síndrome como: palato profundo, alterações oclusais e discreta retrognatia. Quanto às outras alterações sistêmicas características da SM identificadas no paciente foram: miopia, subluxação do cristalino e aneurisma da aorta ascendente. Considerações finais: O dentista deve conhecer os sinais da SM a fim de reduzir a morbimortalidade dos pacientes diante do alto risco de endocardite bacteriana associada a problemas cardiovasculares.
TRATAMENTO	DE	ANQUILOSE	DA	ARTICULAÇÃO	TEMPOROMANDIBULAR SUBSEQUENTE À TRAUMA MANDIBULAR EM PACIENTE PEDIÁTRICO.
Authors: Figueiredo Leonardo Morais Godoy , De Oliveira Thaís Feitosa Leitão , Valente Rômulo Oliveira de Hollanda , Gaspar Alfredo de Alquino , Sarmento Viviane Almeida 
Published: March 2022

A anquilose da articulação temporomandibular (ATM), refere-se à união intracapsular do complexo disco-côndilo à superfície articular do osso temporal, com restrição dos movimentos articulares, e consequente limitação da abertura bucal, restrição da capacidade mastigatória, dificuldade de fonação, higiene bucal precária, além dos transtornos psicológicos como dificuldade de interação social. O presente estudo tem por objetivo relatar um caso clínico de anquilose unilateral na ATM direita em uma paciente do gênero feminino, com nove anos de idade e discutir os aspectos envolvidos no seu tratamento, como a utilização de artroplastia interposicional com enxerto costocondral e retalho de músculo temporal na cirurgia reconstrutiva da ATM. Conclui-se quea artroplastia interposicional com retalho do músculo temporal e enxerto costocondral representa uma excelente alternativa para o tratamento de paciente com anquilose da ATM em fase de crescimento, pois o enxerto costocondral possui características morfológicas semelhantes ao côndilo mandibular, potencial de crescimento, que possibilita que o enxerto acompanhe o surto de crescimento no caso de pacientes pediátricos. O resultado satisfatório do tratamento deve ser atribuído à correta escolha da técnica cirúrgica e ao acompanhamento fisioterápico e fonoaudiológico rigoroso.
LESÃO PERIFÉRICA DE CÉLULAS GIGANTES: RELATO DE CASO DE GRANDES DIMENSÕES PERIPHERAL LESION OF GIANT CELLS: CASE REPORT OF LARGE DIMENSIONS
Authors: Garcia Juliana Jorge , Bispo Carine Rabelo , Neto João Nunes Nogueira , Dantas João Frank Carvalho , Sarmento Viviane Almeida 
Published: March 2022

A lesão periférica de células gigantes, também conhecida como granulomaperiférico de células gigantes, é um processo proliferativo nãoneoplásico reacional causado por irritação ou trauma que ocorre exclusivamentena gengiva ou rebordo alveolar edêntulo. Pode se apresentarcomo um aumento de volume nodular, geralmente de até doiscentímetros de diâmetro e com coloração que varia do vermelho aovermelho azulado. Seu diagnóstico final é histológico e deve ser tratadocom excisão cirúrgica. Objetivo: O objetivo do presente trabalhoé descrever um caso clínico de lesão periférica de células gigantes degrandes dimensões. Relato de Caso: Homem adulto, na oitava décadade vida, procurou atendimento odontológico devido a crescimentotumoral indolor, de grandes dimensões, em rebordo alveolar inferiordesdentado. Realizada biópsia incisional foram observadas célulasgigantes em um estroma fibroso, que confirmou a suspeita de lesãoperiférica de células gigantes. A lesão foi totalmente removida sobanestesia local e o paciente encontra-se em proservação sem sinaisde recidiva. Considerações finais: O diagnóstico diferencial das lesõesem tecidos moles da boca é muito importante, a fim de permitir o tratamentoadequado do paciente. ABSTRACTPeripheral giant cell lesion, also known as giant cell peripheralgranuloma, is a non-neoplastic reactive proliferative process caused byirritation or trauma that occurs exclusively in the gingival or edentulousalveolar ridge. It may present as a nodular volume increase, usually upto two centimeters in diameter and with coloration ranging from redto bluish red. Its final diagnosis is histological and should be treatedwith surgical excision. Objective: The aim of the present study is todescribe a clinical case of large peripheral lesion of giant cells. CaseReport: Adult male, in the eighth decade of life, sought dental care dueto painful tumor growth, large, in the edentulous lower alveolar ridge.Incisional biopsy was performed giant cells in a fibrous stroma, whichconfirmed the suspicion of peripheral lesion of giant cells. The lesionwas completely removed under local anesthesia and the patient isundergoing proservation without signs of relapse. Final considerations:The differential diagnosis of soft-tissue lesions of the mouth is veryimportant in order to allow adequate treatment of the patient.
TOXINA BOTULÍNICA TIPO-A: UMA ALTERNATIVA DE TRATAMENTO PARA O BRUXISMO, REVISÃO DE LITERATURA BOTULINUM TOXIN TYPE-A: AN ALTERNATIVE FOR BRUXISM TREATMENT: LITERATURE REVIEW
Authors: Azevêdo Tharcilla Calíope 
Published: March 2022

O bruxismo é caracterizado pelo ato parafuncional de apertar ou rangerdos dentes, que pode ocorrer de maneira consciente ou inconsciente,durante o sono ou em vigília. Por ser de etiologia complexa, ainda nãoé possível estabelecer um tratamento padrão para todos os pacientes. Aterapêutica com toxina botulínica tipo A (TXB-A) é conservadora, dandoao cirurgião dentista a opção de parar a terapia em qualquer momento eretornar ao estado inicial sem efeitos adversos. Este artigo tem a intençãode demonstrar que a TXB-A pode ser válida no dia a dia da clínica odontológicapara o tratamento do Bruxismo em pacientes onde os sintomasnão foram controlados através dos recursos tradicionalmente oferecidos. Bruxism is characterized by the parafunctional act of grinding or clenchingthe teeth, which may occur in a conscious or unconscious way duringsleep or vigil. Due to its complex ethiology it is not possible yet to stablisha standard treatment to all patients. Treatments using botulinum toxin(TXB-A) are conservative, the dentist may stop at any given time, returningto its starting point, without any side effects. This paper has the intent ofshowing that treating bruxism with TXB-A is a valid alternative for patientswho did not have success with the traditional dental approach.
Assessing the Severity of COVID‐19 Lung Injury in Rheumatic Diseases Versus the General Population Using Deep Learning–Derived Chest Radiograph Scores
Authors: Patel Naomi J. , D'Silva Kristin M. , Li Matthew D. , Hsu Tiffany Y. T. , DiIorio Michael , Fu Xiaoqing , Cook Claire , Prisco Lauren , Martin Lily , Vanni Kathleen M. M. , Zaccardelli Alessandra , Zhang Yuqing , Kalpathy‐Cramer Jayashree , Sparks Jeffrey A. , Wallace Zachary S. 
Published: March 2022

ObjectiveCOVID‐19 patients with rheumatic disease have a higher risk of mechanical ventilation than the general population. The present study was undertaken to assess lung involvement using a validated deep learning algorithm that extracts a quantitative measure of radiographic lung disease severity.MethodsWe performed a comparative cohort study of rheumatic disease patients with COVID‐19 and ≥1 chest radiograph within ±2 weeks of COVID‐19 diagnosis and matched comparators. We used unadjusted and adjusted (for age, Charlson comorbidity index, and interstitial lung disease) quantile regression to compare the maximum pulmonary x‐ray severity (PXS) score at the 10th to 90th percentiles between groups. We evaluated the association of severe PXS score (>9) with mechanical ventilation and death using Cox regression.ResultsWe identified 70 patients with rheumatic disease and 463 general population comparators. Maximum PXS scores were similar in the rheumatic disease patients and comparators at the 10th to 60th percentiles but significantly higher among rheumatic disease patients at the 70th to 90th percentiles (90th percentile score of 10.2 versus 9.2; adjusted P = 0.03). Rheumatic disease patients were more likely to have a PXS score of >9 (20% versus 11%; P = 0.02), indicating severe pulmonary disease. Rheumatic disease patients with PXS scores >9 versus ≤9 had higher risk of mechanical ventilation (hazard ratio [HR] 24.1 [95% confidence interval (95% CI) 6.7, 86.9]) and death (HR 8.2 [95% CI 0.7, 90.4]).ConclusionRheumatic disease patients with COVID‐19 had more severe radiographic lung involvement than comparators. Higher PXS scores were associated with mechanical ventilation and will be important for future studies leveraging big data to assess COVID‐19 outcomes in rheumatic disease patients.
Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm
Authors: Yuan Yi , Feng Zhe , Li Shengliang , Huang Zhongming , Wan Yingpeng , Cao Chen , Lin Sien , Wu Lan , Zhou Jing , Liao Liang‐Sheng , Qian Jun , Lee Chun‐Sing 
Published: March 2022

AbstractMaterials with long‐wavelength second near‐infrared (NIR‐II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom‐programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR‐IIb emissions are developed for bioimaging applications. After self‐assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs are applied as probes for high‐resolution imaging of whole‐body and hind‐limb blood vessels, biliary tract, and bladder with their emissions over 1500 nm. This work demonstrates an atom‐programming strategy for constructing semiconducting small molecules with enhanced NIR‐II fluorescence for deep‐tissue imaging, affording new insight for advancing molecular design of NIR‐II fluorophores.
Emerging Trends in Sustainable CO2‐Management Materials
Authors: Zhang Zhen , Zheng Yun , Qian Lanting , Luo Dan , Dou Haozhen , Wen Guobin , Yu Aiping , Chen Zhongwei 
Published: March 2022

AbstractWith the rising level of atmospheric CO2 worsening climate change, a promising global movement toward carbon neutrality is forming. Sustainable CO2 management based on carbon capture and utilization (CCU) has garnered considerable interest due to its critical role in resolving emission‐control and energy‐supply challenges. Here, a comprehensive review is presented that summarizes the state‐of‐the‐art progress in developing promising materials for sustainable CO2 management in terms of not only capture, catalytic conversion (thermochemistry, electrochemistry, photochemistry, and possible combinations), and direct utilization, but also emerging integrated capture and in situ conversion as well as artificial‐intelligence‐driven smart material study. In particular, insights that span multiple scopes of material research are offered, ranging from mechanistic comprehension of reactions, rational design and precise manipulation of key materials (e.g., carbon nanomaterials, metal–organic frameworks, covalent organic frameworks, zeolites, ionic liquids), to industrial implementation. This review concludes with a summary and new perspectives, especially from multiple aspects of society, which summarizes major difficulties and future potential for implementing advanced materials and technologies in sustainable CO2 management. This work may serve as a guideline and road map for developing CCU material systems, benefiting both scientists and engineers working in this growing and potentially game‐changing area.
Co‐Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced‐Humoral Immunity
Authors: Chang Jason Y. H. , Agarwal Yash , Rodrigues Kristen A. , Momin Noor , Ni Kaiyuan , Read Benjamin J. , Moyer Tyson J. , Mehta Naveen K. , Silva Murillo , Suh Heikyung , Melo Mariane B. , Wittrup K. Dane , Irvine Darrell J. 
Published: March 2022

AbstractProtein antigens are often combined with aluminum hydroxide (alum), the most commonly used adjuvant in licensed vaccines; yet the immunogenicity of alum‐adjuvanted vaccines leaves much room for improvement. Here, the authors demonstrate a strategy for codelivering an immunostimulatory cytokine, the interleukin IL‐21, with an engineered outer domain (eOD) human immunodeficiency virus gp120 Env immunogen eOD, bound together to alum to bolster the humoral immune response. In this approach, the immunogen and cytokine are co‐anchored to alum particles via a short phosphoserine (pSer) peptide linker, promoting stable binding to alum and sustained bioavailability following injection. pSer‐modified eOD and IL‐21 promote enhanced lymphatic drainage and lead to accumulation of the vaccine in B cell follicles in the draining lymph nodes. This in turn promotes enhanced T follicular helper cell priming and robust germinal center responses as well as increased antigen‐specific serum IgG titers. This is a general strategy for codelivery of immunostimulatory cytokine with immunogens providing a facile approach to modulate T cell priming and GC reactions toward enhanced protective immunity using the most common clinical vaccine adjuvant.
Profiling of sulforaphane content in forty‐seven Chinese broccoli germplasms
Authors: Liu Shi‐hui , Wu Qiu‐yun , Xu Ting , Wang Hui‐cong , Wang Jun‐wei , Zhang Zhong‐Lin , Liu Ming‐yue , Huang Ke 
Published: March 2022

AbstractChinese broccoli [Brassica oleracea var. alboglabra (L. H. Bailey) Musil] is an annual herbaceous healthy vegetable plant mainly cultivated in southern China. Previous studies have been primarily focused on investigating the nutritional ingredients of this plant, little is known about its medicinal potentials. Here we report the profiling of sulforaphane, an active ingredient with potent anticancer activities, in 47 Chinese broccoli germplasms collected from China and some southeast‐Asian countries. High‐performance liquid chromatography technology was used to systemically quantify the sulforaphane content in leaf, stem, and flower bud clusters of all 47 Chinese broccoli germplasms. The results indicated a diverse distribution pattern of sulforaphane among different tissues. Flower bud contained the highest average of sulforaphane, roughly twice as much as in leaf and stem tissues. Interestingly, different germplasms exhibited great differences in terms of sulforaphane abundance. Germplasm BOK15‐20 is extremely rich in sulforaphane in all tissues tested, ∼2,500 times of BOK15‐15 in leaf, 66 times of BOK15‐42 in the stem, and 77 times of BOK15‐40 in flower bud. The tremendous disparity of sulforaphane content among different germplasms suggests considerable variations in germplasms’ medicinal potentials. In addition, we systemically characterized a series of morphological and phenotypic traits of all 47 Chinese broccoli germplasms. Cluster analysis through NTSYSpc v2.2 showed that the 47 germplasms were classified into five different groups, respectively, based on sulforaphane content and qualitative phenotypic traits. Our results not only confirmed the medicinal values of Chinese broccoli but also provided crucial information that will eventually benefit future germplasm development and new variety breeding.
Registry data analysis of hematopoietic stem cell transplantation on systemic chronic active Epstein–Barr virus infection patients in Japan
Authors: Yamamoto Masahide , Sato Maho , Onishi Yasushi , Sasahara Yoji , Sano Hideki , Masuko Masayoshi , Nakamae Hirohisa , Matsuoka Ken‐ichi , Ara Takahide , Washio Kana , Onizuka Makoto , Watanabe Kenichiro , Takahashi Yoshiyuki , Hirakawa Tsuneaki , Nishio Miwako , Sakashita Chizuko , Kobayashi Tohru , Sawada Akihisa , Ichinohe Tatsuo , Fukuda Takahiro , Hashii Yoshiko , Atsuta Yoshiko , Arai Ayako 
Published: March 2022

AbstractThe effects of allogeneic hematopoietic stem cell transplantation (allo‐HSCT) on systemic chronic active Epstein–Barr virus infection (sCAEBV) are yet to be analyzed in a large number of patients. Using the Japanese registry database, Transplant Registry Unification Management Program, we investigated the outcomes of 102 sCAEBV patients who underwent allo‐HSCT. The median age at HSCT was 21 years, and the three‐year overall survival (3‐year OS) rate was 72.5%. Of the 90 patients whose viral load after allo‐HSCT was evaluated, 56 (62.2%) achieved a virological complete response, defined by the complete resolution of disease activity with a significant decrease in EBV‐DNA in peripheral blood. The multivariate Cox proportional hazard model indicated that advanced age, in adolescents and young adults (AYA) (age, 15–39) and adults (age, ≥40 years) was a risk factor of poor OS. The hazard ratios (HRs) of the AYA and adult groups were 10.87 (95% confidence interval [CI]: 1.98–59.56, p = .006) and 15.93 (95% CI: 2.45–103.8, p = .004), respectively. Disease activity (HR 5.74), elevated soluble IL‐2 receptor (sIL‐2R) (≥ median, 691 U/mL) at HSCT (HR 6.93), and conditioning without radiotherapy (HR 3.53) were also independently associated with poor survival. Notably, 79% of radiotherapy doses were less than 6 Gy. Regardless of the presence of hemophagocytic lymphohistiocytosis, the group with a high sIL‐2R level (≥2000 U/mL) showed a poorer prognosis. Although allo‐HSCT is the only curative therapy for sCAEBV, treatment strategies need to be improved for high‐risk patients, especially those with high levels of sIL‐2R.
Systematic analysis of physical examination characteristics of 94 individuals with Joubert syndrome: Keys to suspecting the diagnosis
Authors: Forsyth RaeLynn , Parisi Melissa A. , Altintas Burak , Malicdan May Christine , Vilboux Thierry , Knoll Jasmine , Brooks Brian P. , Zein Wadih M. , Gahl William A. , Toro Camilo , Gunay‐Aygun Meral 
Published: March 2022

AbstractJoubert syndrome (JS) is a neurodevelopmental disorder characterized by hypotonia and developmental delay, as well as the obligatory molar tooth sign on brain imaging. Since hypotonia and developmental delay are nonspecific features, there must be a high level of clinical suspicion of JS so that the diagnostic brain imaging and/or molecular testing for the >38 genes associated with JS is/are obtained. The goal of this study was to analyze clinical photographs of a cohort of patients with JS to define a list of physical examination features that should prompt investigation for JS. Analysis of photographs from 94 individuals with JS revealed that there is a recognizable pattern of facial features in JS that changes over time as individuals age. Macrocephaly, head tilting even when looking straight ahead, eye movement abnormalities (oculomotor apraxia, nystagmus, strabismus), and ptosis are common in those with JS. Distinctive features in younger children include triangular‐shaped open mouth with tongue protrusion; in older children and adults, mandibular prognathia and prominent nasal bridge are common.