bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winter‐type oilseed pennycress crop staging guide
Authors: Verhoff Kyle , Phippen Winthrop , Heller Nicholas , Lindsey Alexander 
Published: May 2022

AbstractOilseed pennycress (Thalspi arvense L.) is a crop that has undergone domestication for use as a new oilseed option in parts of the United States for use in biofuel and livestock feed production but does not yet have management resources such as a growth staging guide. Winter types of this crop may have utility in existing summer annual rotations throughout much of the U.S. Midwest by growing during the fall/winter fallow period. This guide contains an adaptation of the Biologische Bundesanstalt, Bundessortenamt und Chemische Industrie (BBCH)‐staging method used in other oilseeds and integrates management considerations and key physiological development stages for this new crop. The implementation of substages within a predominant phase of growth in this guide is more reflective of the Feekes growth staging system for small grains with which U.S. Midwest producers commonly use. Utilization of a common staging system for winter‐type pennycress will help with development of future management guides and pesticide labeling practices and will help connect producers and consultants to ensure management practices are employed at the appropriate growth stages.
Fe2 Dimers for Non‐Polar Diatomic O2 Electroreduction
Authors: Fan Ruxue , Wang Haiyan , Zheng Xiaozhong , Chen Jiadong , Ou Yang , Wang Yong , Mao Shanjun 
Published: May 2022

AbstractNon‐polar diatomic molecule activation is of great significance for catalysis. Despite the high atomic efficiency, the catalytic performance of single‐atom catalysts is limited by insufficient receiving sites for diatomic molecule adsorption. Here, Fe2 dimers were successfully synthesized through precisely regulating the metal loading on metal‐organic frameworks. The unique role of metal dimers in activating diatomic O2 molecules was explored. In alkaline electrolytes, the specific oxygen reduction reaction activity of Fe2 dimers was 7 times higher than that of Fe1 counterparts. The hydrogen atom transfer probes indicated a different activation mode for O2 on Fe1 and Fe2 dimers, respectively. Theoretical calculation results revealed that Fe2 dimers opened up a new reaction pathway by promoting the direct breaking of O=O bonds, thus avoiding the usual formation of *OOH intermediates, which helped explain the lower H2O2 yield and higher specific activity.
FL118, acting as a ‘molecular glue degrader’, binds to, dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy
Authors: Ling Xiang , Wu Wenjie , Aljahdali Ieman A. M. , Liao Jianqun , Santha Sreevidya , Fountzilas Christos , Boland Patrick M. , Li Fengzhi 
Published: May 2022

ABSTRACTBackgroundPancreatic ductal adenocarcinoma (PDAC), a difficult‐to‐treat cancer, is expected to become the second‐largest cause of cancer‐related deaths by 2030, while colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer deaths. Currently, there is no effective treatment for PDAC patients. The development of novel agents to effectively treat these cancers remains an unmet clinical need. FL118, a novel anticancer small molecule, exhibits high efficacy against cancers; however, the direct biochemical target of FL118 is unknown.MethodsFL118 affinity purification, mass spectrometry, Nanosep centrifugal device and isothermal titration calorimetry were used for identifying and confirming FL118 binding to DDX5/p68 and its binding affinity. Immunoprecipitation (IP), western blots, real‐time reverse transcription PCR, gene silencing, overexpression (OE) and knockout (KO) were used for analysing gene/protein function and expression. Chromatin IP was used for analysing protein‐DNA interactions. The 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromid assay and human PDAC/CRC cell/tumour models were used for determining PDAC/CRC cell/tumour in vitro and in vivo growth.ResultsWe discovered that FL118 strongly binds to, dephosphorylates and degrades the DDX5 oncoprotein via the proteasome degradation pathway without decreasing DDX5 mRNA. Silencing and OE of DDX5 indicated that DDX5 is a master regulator for controlling the expression of multiple oncogenic proteins, including survivin, Mcl‐1, XIAP, cIAP2, c‐Myc and mutant Kras. Genetic manipulation of DDX5 in PDAC cells affects tumour growth. PDAC cells with DDX5 KO are resistant to FL118 treatment. Our human tumour animal model studies further indicated that FL118 exhibits high efficacy to eliminate human PDAC and CRC tumours that have a high expression of DDX5, while FL118 exhibits less effectiveness in PDAC and CRC tumours with low DDX5 expression.ConclusionDDX5 is a bona fide FL118 direct target and can act as a biomarker for predicting PDAC and CRC tumour sensitivity to FL118. This would greatly impact FL118 precision medicine for patients with advanced PDAC or advanced CRC in the clinic. FL118 may act as a ‘molecular glue degrader’ to directly glue DDX5 and ubiquitination regulators together to degrade DDX5.
Resource selection by greater sage‐grouse varies by season and infrastructure type in a Colorado oil and gas field
Authors: Walker Brett L. 
Published: May 2022

AbstractEnergy development is one of the most rapidly increasing land uses in North America, so understanding how wildlife respond to different types of energy infrastructure is crucial for informing land‐use policies. Effects of energy development on wildlife habitat use and selection can vary depending on infrastructure type, level of industrial activity, and density. I examined seasonal habitat use and selection of greater sage‐grouse in relation to energy development in a high‐elevation oil and gas field in western Colorado by linking spatially and temporally explicit energy infrastructure layers with telemetry locations of marked females from 2006 to 2014. Objectives were to (1) quantify energy infrastructure around seasonal use locations; (2) examine how seasonal resource selection is affected by energy infrastructure with disturbed versus reclaimed surface and different levels of industrial activity; and (3) assess current surface disturbance and infrastructure density caps. Between 92% and 97% of seasonal use locations had <3% disturbed surface within 1000 m. After accounting for landcover and topography, breeding and wintering females selected locations with less disturbed, reclaimed, and total anthropogenic surface. Breeding females selected locations farther from high‐activity well pads and facilities. In contrast, females selected locations with low to intermediate values of disturbed and reclaimed surface and locations closer to pipelines and roads in summer–fall. This is the first evidence that greater sage‐grouse select locations with energy infrastructure in any season and suggests that responses to energy development may differ between mesic and arid sagebrush ecosystems. Females avoided locations with >1.1%–2.5% disturbed surface during breeding and winter and selected locations with lower densities of active energy features during breeding and roads in winter. Density caps of one active energy feature and 1.5 mi (2.41 km) of road per section were adequate to prevent avoidance except during the breeding season. Disturbance caps should be set at 1.1% disturbed surface and 1.8% total anthropogenic surface in breeding habitat and 2.5% disturbed surface and 3.5% total anthropogenic surface in winter habitat to minimize negative impacts on female habitat selection in this population. Results also support timing restrictions on construction and drilling during breeding and rapid transitioning of well pads from drilling to production.
Outcomes with empagliflozin in heart failure with preserved ejection fraction using DELIVER‐like endpoint definitions
Authors: Anker Stefan D. , Siddiqi Tariq Jamal , Filippatos Gerasimos , Zannad Faiez , Ferreira João Pedro , Pocock Stuart J. , Brueckmann Martina , Zeller Cordula , Packer Milton , Butler Javed 
Published: May 2022

AimsTo report data from EMPEROR‐Preserved according to prespecified endpoints of DELIVER.Methods and resultsIn order to assess the impact of DELIVER‐like definition on EMPEROR‐Preserved outcomes, the following differences were reconciled: (1) the primary outcome in DELIVER added urgent heart failure (HF) visits to cardiovascular death or HF hospitalizations; (2) the EMPEROR‐Preserved trial did not require documentation of physical findings or laboratory tests for confirming a HF hospitalization and it included events of 12–24 h if intensification of treatment was not only oral diuretics; (3) DELIVER excluded undetermined causes of deaths from the primary endpoint; (4) the composite renal endpoint in DELIVER included a sustained ≥50% decline in estimated glomerular filtration rate and incorporated renal death; and (5) DELIVER will assess outcomes in the overall population and in patients with ejection fraction (EF) <60% separately. Using the endpoint definitions from DELIVER, the primary outcome overall occurred in 13.1% in the empagliflozin and 16.8% in the placebo group (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.67–0.87; p < 0.0001). The relative risk reduction (RRR) changed from 21% to 24% when urgent HF visits were added, and undetermined death was eliminated. Compared to overall population RRR of 24%, it was 28% in patients with EF <60%. Death from cardiovascular causes excluding undetermined causes occurred in 6.2% in the empagliflozin and in 7.1% in the placebo group (HR 0.88, 95% CI 0.73–1.07). The RRR for the composite renal endpoint changed from 22% in the overall population (HR 0.78, 95% CI 0.54–1.13) to 40% when patients with EF <60% were assessed (p = 0.037).ConclusionFindings from EMPEROR‐Preserved were modestly altered when analysed using cardiovascular trial endpoint definitions of the DELIVER trial. For the composite renal endpoint, the effect of empagliflozin became statistically significant in patients with EF <60% using the DELIVER definition.
Solvated Actinoids: Methanol, Ethanol, and Water Adducts of Thorium and Uranium Tetrachloride
Authors: Kasperowicz Thomas , Flosbach Niko T. , Grödler Dennis , Kasperowicz Hannah , Neudörfl Jörg‐M. , Rennebaum Tobias , Wickleder Mathias S. , Zegke Markus 
Published: May 2022

AbstractThe solvent adducts of the tetravalent actinoid chlorides ThCl4 and UCl4 have been isolated with methanol as [ThCl4(MeOH)4] 1 and [UCl4(MeOH)4] 2, and with ethanol as [ThCl4(EtOH)4] 3 and [UCl4(EtOH)4] 4. In hydrochloric acid [ThCl2(H2O)7](Cl)2(H2O)2 5 forms, which is isotypic to the known [UCl2(H2O)7](Cl)2(H2O)2 6. The adducts have been analysed using SXRD, IR, CHN, TGA‐MS and PXRD. The material can be isolated from saturated organic (1–4) or acidic aqueous (5–6) solutions, however, drying of the isolated material results in loss of HCl and the formation of oxide species, confirmed by the isolation of U3O8 after complete thermal decomposition.
Coping expectancies and disability across the new ICD‐11 chronic pain categories: A large‐scale registry study
Authors: Munk Alice , Jacobsen Henrik Børsting , Reme Silje Endresen 
Published: May 2022

AbstractBackgroundRecently, a new classification system for chronic pain was included in the 11th edition of the International Classification of Diseases (ICD‐11). This study aims to investigate how expectancies of coping, that is pain catastrophizing and general self‐efficacy, are associated with ICD‐11 chronic pain categories in a large pain clinic population. Furthermore, we investigate how coping expectancies are associated with pain‐related disability, cross‐sectionally and longitudinally across the novel pain classifications.MethodsThe sample was retrieved from the Oslo University Hospital Pain Registry and included baseline data from 2875 chronic pain patients and 12‐month follow‐up data for 920 patients. Demographic and clinical variables were compared across the ICD‐11 chronic pain categories through ANOVA. Multiple regression models were carried out to investigate cross‐sectional and longitudinal associations.ResultsWith the exception of age, our data showed no significant differences across the ICD‐11 chronic pain categories. Coping expectancies were associated with disability at baseline. At 12‐month follow‐up, coping expectancies did not predict pain‐related disability when controlling for baseline levels of disability, pain intensity and pain duration. Pain classification (primary vs secondary) did not contribute significantly to the models. Helplessness had the strongest simple relationship to disability, compared with global pain catastrophizing and its additional subscales, both cross‐sectionally and longitudinally.ConclusionCoping expectancies, pain intensity and pain‐related disability appear similar across the novel chronic pain classifications, indicating that all pain patients may benefit from targeting these variables. Consistent with recent developments in stress theory, helplessness and self‐efficacy were cross‐sectionally associated with negative pain outcomes.SignificanceLevels of coping expectancies, demographic characteristics, pain‐related disability and pain intensity are similar across all ICD‐11 chronic pain diagnostic categories. Thus, chronic primary pain is not stronger associated with psychosocial factors such as catastrophizing and self‐efficacy than chronic secondary pain. Therefore, chronic pain patients, independent of diagnosis, may benefit from the assessment of these psychosocial factors and targeted interventions such as CBT should be considered.
Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan
Authors: Kishi Yasuiro , Takumi Ichiro , Yamamoto Hitoshi , Ishimaru Takako , Thurber Steven 
Published: May 2022

AbstractObjectiveThe relationship between care complexity and quality of life among patients with epilepsy has not been assessed, especially in Japan. The aim of this study is to test the hypothesis that care complexity is associated with health‐related quality of life (HRQOL) and mood disturbance.MethodThis was an observational cross‐sectional study. The study included a consecutive series of 49 patients who newly visited an epilepsy center. Study participants were administered standardized quantitative measures of HRQOL, case complexity, and depression.ResultsPatient complexity predicted lower HRQL scores. Data on the social and psychological complexity domains predicted patient HRQOL findings more accurately than data from the biological domain of the case complexity scale. Seizure frequency was unrelated to HRQOL findings in this study. Additionally, depression scores were also associated with lower HRQOL.SignificanceA patient complexity assessment, including psychological and social domains, may be one of the key tools in epilepsy treatment settings. Further studies using larger random selection from patients with epilepsy are necessary to generalize the findings to patients in other epilepsy programs.
Incidence and factors associated with post‐anesthesia care unit complications in resource‐limited settings: An observational study
Authors: Abebe Bisrat , Kifle Natnael , Gunta Muluken , Tantu Temesgen , Wondwosen Mekete , Zewdu Dereje 
Published: May 2022

AbstractBackground and aimsPostoperative complications are frequent encounters in the patients admitted to postanesthesia care units (PACU). The main aim of this study was to assess the incidence of complications and associated factors among surgical patients admitted in limited‐resource settings of the PACU.MethodsThis is an observational study of 396 surgical patients admitted to PACU. This study was conducted from February 1 to March 30, 2021, in Ethiopia. Study participants' demographics, anesthesia, and surgery‐related parameters, PACU complications, and length of stay in PACU were documented. Multivariate and bivariate logistic regression analyses, the odds ratio (OR), and 95% confidence interval (CI) were calculated. p‐value < 0.05 was considered as statistically significant.ResultsThe incidence of complications among surgical patients admitted to PACU was 54.8%. Of these, respiratory‐related complications and postoperative nausea/vomiting were the most common types of PACU complications. Being a female (adjusted odds ratio [AOR] = 2.928; 95% CI: 1.899–4.512) was significantly associated with an increased risk of developing PACU complications. Duration of anesthesia >4 h (AOR = 5.406; 95% CI: 2.418–12.088) revealed an increased risk of association with PACU complications. The occurrences of intraoperative complications (AOR = 2.238; 95% CI: 0.991–5.056) during surgery were also associated with PACU complications. Patients who develop PACU complications were strongly associated with length of PACU stay for >4 h (AOR = 2.177; 95% CI: 0.741–6.401).ConclusionThe identified risk factors for complications in surgical patients admitted to PACU are female sex, longer duration of anesthesia, and intraoperative complications occurrences. Patients who developed complications had a long time of stay in PACU. Based on our findings, we recommend the PACU team needs to develop area‐specific institutional guidelines and protocols to improve the patients' quality of care and outcomes in PACU.
‎Factors associated with coronavirus disease 2019 infection severity among a sample of Lebanese adults: Data from a cross‐sectional study
Authors: El‐Hayek Elissar , Kahwagi Georges‐Junior , Issy Nour , Tawil Christina , Younis Nabil , Abou‐Khalil Rony , Matar Madonna , Hallit Souheil 
Published: May 2022

AbstractBackground and AimsIdentification of factors responsible for severe illness related to coronavirus disease 2019 (COVID‐19) could help in the early management of patients with high risk, especially in developing countries with poor medical care systems. To date, no data have been published concerning the factors associated with COVID‐19 severity in Lebanon. In this study, we aimed at investigating the relation between sociodemographic variables, health status, and the clinical outcomes of COVID‐19 in a sample of Lebanese adults.MethodsIn our cross‐sectional study, 1052 patients (563 male and 489 female, with the median age of 42.83 ± 17.88 years), tested positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) between January and March 2021, were recruited from a hospital in Byblos, Lebanon. Basic demographic data, medical history, clinical data, and selfreported symptoms related to COVID‐19 were collected. Clinical classification of COVID‐19 severity was carried out according to the WHO interim guidance on May 27, 2020. Multi and bivariate regression analysis were performed.ResultsWhen comparing patients with moderate symptoms versus mild, the results showed that older age (aOR = 1.05; 95% CI: 1.03–1.06) and having dyslipidemia (aOR = 1.89; 95% CI: 1.01–3.49) were significantly associated with higher odds of having moderate symptoms. When comparing patients with severe symptoms versus mild, older age (aOR = 1.08; 95% CI: 1.06–1.10), higher body mass index (aOR = 1.09; 95% CI: 1.04–1.15) and having respiratory diseases (aOR = 2.57; 95% CI: 1.03–6.36) were significantly associated with higher odds of having severe symptoms, whereas female gender (aOR = 0.56; 95% CI: 0.32–0.98) was significantly associated with lower odds of having severe symptoms compared to males. Finally, when comparing patients with severe symptoms versus moderate, older age (aOR = 1.03; 95% CI: 1.01–1.05) was found to be significantly associated with higher odds of having severe symptoms.ConclusionIdentification of risk factors may contribute to a better understanding of the COVID‐19 pathogenesis and provide clinical reference for early prognosis and management of patients.
Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEMⓇ): A retrospective study
Authors: Matsuoka Ayaka , Koami Hiroyuki , Shinada Kota , Sasaki Akira , Yamazaki Hirotaka , Mori Kosuke , Nakayama Kento , Asahi Miho , Yoshitake Kunimasa , Narumi Shogo , Koba Mayuko , Kawaguchi Atsushi , Sakamoto Yuichiro 
Published: May 2022

AbstractBackgroundHemorrhagic complications in patients with coronavirus 19 disease (COVID‐19) are infrequent but associated with a prognosis. This study aimed to elucidate the risk factors for bleeding complications in patients with COVID‐19 using rotational thromboelastometry (ROTEM) parameters and blood tests performed at admission.MethodsIn total, 31 patients with severe COVID‐19 treated intensively at Saga University Hospital were included in this study. Patients were divided into two groups according to the presence or absence of hemorrhagic complications. Results from the blood tests performed at admission and during hospitalization, and ROTEM values acquired upon admission, were compared between the two groups.ResultsThere were significant differences in ROTEM values upon admission between the bleeding and non‐bleeding groups. Receiver operating curve analysis showed that the area under the curve for prothrombin time international normalized ratio (PT‐INR) and extrinsically‐activated test with tissue factor (EXTEM) amplitude at 10 min (A10) were 0.82 (0.52–0.92) and 0.81 (0.58–0.93), respectively. Logistic regression analysis with PT‐INR and EXTEM A10 as factors calculated an odds ratio of 1.94 (1.04–3.62) and EXTEM A10 0.86 (0.71–1.05) for bleeding complications occurrence.ConclusionROTEM may be a sensitive predictor for bleeding complications in patients with COVID‐19.
Prevalence of hepatitis B virus and associated risk factors among adults patients at Dessie referral and Kemise general hospitals in northeastern Ethiopia
Authors: Mohammed Hussein , Eshetie Aragaw , Melese Dessie 
Published: May 2022

AbstractBackground and AimsHepatitis is an inflammation of the liver that can reason a variety of health problems and can be fatal. According to the most recent estimates of the Global Burden of Disease study and WHO, viral hepatitis is accountable for around 1.34 million deaths yearly, which is comparable to the yearly number of deaths from HIV/AIDS (1.3 million), malaria (0.9 million), and tuberculosis (1.3 million). This study aimed to assess the prevalence of the Hepatitis B virus and associated risk factors among adults patients at Dessie Referral and Kemise General Hospitals.MethodsThe source for the data on Hepatitis B virus (HBV) was all adults aged≥18 years that were admitted and tested for HBV from September 2020 to February 2021 were included in the study. A total of 1283 adults were admitted out of which, 1080 adults have completed measurements and had been taken into consideration for this examination, and others had been excluded from the examination because of exclusion criteria. To meet our objective descriptive statistics, the χ2 test and multiple logistic regression statistical models were used for data analysis.ResultsIn this study, a total of 1080 adults were included out of which 631 (58.4%) female and 449 (41.6%) were male with a mean age of 34(SD ± 12.56) years. The overall prevalence of HBV among adults was 27.4% (95% confidence interval [CI];24.8–30.2). The results of this study showed that age 25–34(odds ratio [OR] = 3.6, p‐value = 0.005), 35–44 (OR = 6.67, p‐value <0.001), ≥45 (OR = 3.85, p‐value = 0.005), male (OR = 4.36, p‐value < 0.001), history of hospitalization (OR = 0.644, p‐value = 0.04), family history of HBV (OR = 1.96, p‐value = 0.005), and jaundice (OR = 2.50, p‐value = 0.005) were significant risk factors of HBV.ConclusionThe prevalence of HBV in this study is 27.4%. The results of this study showed that age, male, history of hospitalization, family history of HBV, and jaundice were significant risk factors for Hepatitis B virus.