bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ylirajaiset traumakulttuurit ja Sofi Oksasen Puhdistus
Authors: Jytilä Riitta 
Published: June 2022

Tutkin artikkelissani Sofi Oksasen Puhdistusta (2008) ylirajaisen traumakulttuurin näkökulmasta. Keskittyessään Viron lähihistoriaan ja eri sukupolville periytyvän tahallisen ja tahattoman unohtamisen taakkaan Puhdistus tuo esiin Suomessa vähemmälle huomiolle jääneitä Neuvostoliiton ja Itä-Euroopan traumahistorioita. Tutkin Puhdistusta sekä vastaanoton että teosanalyysin kannalta. Niiden lisäksi nostan esiin kirjailijan roolin yhteiskunnallisen keskustelun herättäjänä. Hyödynnän artikkelissa muisti- ja traumatutkimuksen, ylirajaisuuden tutkimuksen sekä postkoloniaalisen tutkimuksen tuoreimpia näkökulmia. Aluksi kartoitan Itä-Euroopan ylirajaista muisti- ja traumakulttuurien kenttää historioitsija Timothy Snyderin tappotanner-käsitteen (Bloodlands) avulla sekä sijoitan Oksasen ”Gulag-kirjallisuuden” kenttään. Sen jälkeen tarkastelen Oksasta traumakulttuurin kierrättäjänä, joka on julkisissa rooleissa, kirjailijana, kustantajana ja historioitsijana, tuottanut ylirajaista kulttuurista muistia. Käsittelen myös Puhdistuksen herättämää keskustelua muistojen kansallisesta omistusoikeudesta Suomessa ja Virossa. Artikkelini osoittaa, että Oksanen on traumahistorioiden kierrättäjänä ja kansallista lähtökohtaa purkavalla otteellaan hämmentänyt keskustelua kirjallisuudesta historian tuottajana.

In this article, I will study the work of the Finnish-Estonian writer Sofi Oksanen by concentrating on her internationally acclaimed novel, Purge (2008). In Finland, the novel raises the question of the burden of remembering in post-Soviet and Eastern Europe trauma histories in the spirit of new global memory studies, where memories are considered to transfer different social constellations and political contexts. In the article, I study Oksanen’s novel and its reception by bringing together the most recent discussions of trauma theory, transborder studies and postcolonial studies. First, I chart the field of transborder trauma cultures by using Timothy Snyder’s concept of the Bloodlands – by which he refers to the area of Eastern Europe whose populations were subjected to Soviet, Nazi and then again Soviet genocidal practices. Secondly, I discuss Oksanen as a cultural agent, who has dedicated much of her versatile cultural agency to mediating the memory of the 20th-century Soviet terror in Estonia to the Finnish and international public – as a writer, publisher and editor. The analysis of the novel and its reception in both Finland and Estonia enables us to look at Oksanen’s ways of engaging in the debates concerning memory and historical knowledge from a transcultural perspective.
Eero O. Erkko – nationalisti-insinööri nuoressa tasavallassa
Authors: Jensen-Eriksen Niklas 
Published: June 2022

Eero O. Erkko (1899–1969) oli diplomi-insinööri, kemisti, nationalisti ja Helsingin Sanomien omistajasuvun jäsen. Artikkelissa tarkastellaan hänen urakehitystään ja toimintaansa maailmansotien välisenä aikana. Erkko halusi vahvistaa kotimaansa taloutta ja heikentää ulkomaalaisten roolia. Työtoverina hän oli vaikea. Erkko työskenteli useiden valtionyritysten palveluksessa ja heittäytyi innolla mukaan niiden sisäisiin valtataisteluihin. Erkon voimakkain ase oli julkisuus: hän ujutti sukulehtensä sivuille epäedullisia artikkeleita valtionyritysten johtajien toiminnasta. Lopulta lahjakkaan, mutta monia siltoja polttaneen, diplomi-insinöörin oli vaikea löytää uutta työtä, joten hän päätti muuttaa Yhdysvaltoihin.
Improving Student's Logical Thinking Abilities And Learning Outcomes Through Guided Inquiry Model
Authors: Yuliana Nur , Purwati Nining , Hanapi Hanapi 
Published: June 2022

The abilities of students can affect learning outcomes. One capability that is closely related to learning outcomes is the ability to think logically which improves students’ understanding of knowledge. This study aims to determine cognitive learning outcomes and logical thinking ability of students in science subjects through the guided inquiry learning model. The quasi-experimental research was conducted with a non-equivalent pretest-posttest control group design. The population was all students of seventh grade of Miftahul Ishlah Islamic Junior high School in Mataram-Lombok.The sample was determined by cluster random sampling technique. The subjective test and the rubric of logical thinking ability were instruments used. Data were analyzed using SPSS MANCOVA, which preceded the prerequisite test, ie test for normality and homogeneity. The results showed that the guided inquiry learning model had a significant effect on the student's cognitive learning outcomes and logical thinking ability with p = 0.000, and its’ corrected mean score of learning outcomes was 95%, and corrected mean score of logical thinking ability was 71%, higher than that of student in the conventional learning model.
Saúde mental na população negra: conhecimentos e práticas de docentes e discentes de gestão hospitalar
Authors: Santos Ana Cristina de Macedo , Santos Alexandy Michel Dantas , Salvador Pétala Tuani Candido de Oliveira , Barros Rosires Magali Bezerra de , Meira Karina Cardoso , Oliveira Lannuzya Veríssimo e 
Published: June 2022

O objetivo do artigo é compreender os conhecimentos e as práticas de docentes e discentes do curso de graduação em Gestão Hospitalar sobre a saúde mental da população negra. Trata-se de um estudo descritivo, com abordagem qualitativa realizado entre os meses de julho e agosto de 2021, com discentes e docentes do curso de Gestão Hospitalar da Universidade Federal do Rio Grande do Norte. Para coleta de dados, que ocorreu via plataforma zoom meeting, foi utilizado um questionário sociodemográfico e uma entrevista semiestruturada. A amostra foi encerrada em 12 sujeitos, seguindo o critério de saturação teórica das falas. Realizou-se a análise de conteúdo dos dados. Os participantes da pesquisa eram, em sua maioria, do sexo feminino, solteiros, com média de idade de 29 anos, que se autodeclararam pardos. Da análise emergiram as seguintes categorias: I- Discriminação racial e os impactos na saúde (mental) da população negra; II- Saúde mental da população negra na teoria e prática; e III- (In)formação para gestão democrática e inclusiva. A temática em tela é pouco abordada durante o curso de gestão hospitalar, apesar dos sujeitos da pesquisa compreenderem a relevância da saúde mental da população negra no âmbito da saúde pública.
Chronic and Cumulative Adverse Life Events in Women with Primary Ovarian Insufficiency: An Exploratory Qualitative Study
Authors: Sun Junyan , Fan Yihui , Guo Ying , Pan Huiying , Zhang Chen , Mao Guoping , Huang Yating , Li Boning , Gu Tingting , Wang Lulu , Zhang Qiuwan , Wang Qian , Zhou Qian , Li Bai , Lai Dongmei 
Published: June 2022

Background and PurposePrimary ovarian insufficiency (POI) has serious physical and psychological consequences due to estradiol deprivation, leading to increased morbidity and mortality. However, the causes of most POI cases remain unknown. Psychological stress, usually caused by stressful life events, is known to be negatively associated with ovarian function. It is important to explore high-frequency adverse life events among women with POI for future interventions.MethodsForty-three women (mean age=33·8 years) were recruited who were newly- diagnosed with idiopathic POI (FSH levels &gt;40 IU/L) to participate in semi-structured interviews through convenience sampling. The main questions covered by the topic guide were designed to explore adverse life events prior to POI diagnosis. Interviews were audio recorded, transcribed and analyzed thematically. Data were analyzed from June 2019 to August 2020.ResultsAmong the women with POI, mean age at diagnosis of POI was 33·8 years (range from 19 to 39 years), and the average time between the onset of irregular menstruation and POI diagnosis was 2.3 years. These women with POI had a relatively normal menstrual cycle before the diagnosis. A number of stressful life events prior to POI diagnosis were discussed by them as important factors influencing their health. Four core themes emerged: 1) persistent exposure to workplace stress, 2) persistent exposure to family-related adverse life events, 3) sleep problem/disturbance existed in women with POI before diagnosis, and 4) participants’ general cognition and concerns about POI.ConclusionsPersistent exposures to adverse life events related to work stress, family stress and sleep problem existed in women with POI. Our findings are consistent with the hypothesis that adverse life events play a role in the development of POI. Future research should investigate how social environmental factors influence POI disease risks, and whether provision of tailored interventions (i.e. preventing or mitigating impact of adverse life events) aimed at high-risk populations may help prevent new POI cases and improve conditions of women with POI. We gained an in-depth understanding of the experiences of these women via 1:1 qualitative method, and find adverse life events are frequent in women with POI prior to the diagnosis.
Safety Parameters of Quantum Molecular Resonance Devices During Thyroid Surgery: Porcine Model Using Continuous Neuromonitoring
Authors: Tseng Hsin-Yi , Huang Tzu-Yen , Lin Yi-Chu , Wang Jia Joanna , Ko How-Yun , Chuang Cheng-Hsun , Lu I-Cheng , Chang Pi-Ying , Randolph Gregory W. , Dionigi Gianlorenzo , Chang Ning-Chia , Wu Che-Wei 
Published: June 2022

ObjectivesQuantum molecular resonance (QMR) devices have been applied as energy-based devices in many head and neck surgeries; however, research on their use in thyroid surgery is lacking. This study aimed to investigate the safety parameters of QMR devices during thyroidectomy when dissection was adjacent to the recurrent laryngeal nerve (RLN).MethodsThis study included eight piglets with 16 RLNs, and real-time electromyography (EMG) signals were obtained from continuous intraoperative neuromonitoring (C-IONM). QMR bipolar scissor (BS) and monopolar unit (MU) were tested for safety parameters. In the activation study, QMR devices were activated at varying distances from the RLN. In the cooling study, QMR devices were cooled for varying time intervals, with or without muscle touch maneuver (MTM) before contacting with the RLN.ResultsIn the activation study, no adverse EMG change occurred when QMR BS and MU were activated at distances of 2 mm or longer from the RLNs. In the cooling study, no adverse EMG change occurred when QMR BS and MU were cooled in 2-second intervals or immediately after MTM.ConclusionQMR devices should be carefully used when performing RLN dissection during thyroid surgery. According to the activation and cooling safety parameters in this study, surgeons can avoid RLN injury by following standard procedures when using QMR devices.
Activation of Cholinergic Anti-Inflammatory Pathway Ameliorates Cerebral and Cardiac Dysfunction After Intracerebral Hemorrhage Through Autophagy
Authors: Su Yue , Zhang Wei , Zhang Ruoxi , Yuan Quan , Wu Ruixia , Liu Xiaoxuan , Wuri Jimusi , Li Ran , Yan Tao 
Published: June 2022

BackgroundIntracerebral hemorrhage (ICH) is the devastating subtype of stroke with cardiovascular complications, resulting in high rates of mortality and morbidity with the release of inflammatory factors. Previous studies have demonstrated that activation of α7nAChR can reduce immune and inflammation-related diseases by triggering the cholinergic anti-inflammatory pathway (CAIP). α7nAChR mediates protection from nervous system inflammation through AMPK-mTOR-p70S6K-associated autophagy. Therefore, the purpose of this study is to explore whether the activation of α7nAChR improves cerebral and cardiac dysfunction after ICH through autophagy.MethodsMale C57BL/6 mice were randomly divided into five groups (1): Control + saline (2), ICH+ saline (3), ICH + PNU-282987 (4), ICH+ PNU-282987 + MLA (5), ICH + PNU-282987 + 3-MA. The neurological function was evaluated at multiple time points. Brain water content was measured at 3 days after ICH to assess the severity of brain edema. PCR, immunofluorescence staining, and Western Blot were performed at 7 days after ICH to detect inflammation and autophagy. Picro-Sirius Red staining was measured at 30 days after ICH to evaluate myocardial fibrosis, echocardiography was performed at 3 and 30 days to measure cardiac function.ResultsOur results indicated that the PNU-282987 reduced inflammatory factors (MCP-1, IL-1β, MMP-9, TNF-α, HMGB1, TLR2), promoted the polarization of macrophage/microglia into anti-inflammatory subtypes(CD206), repaired blood-brain barrier injury (ZO-1, Claudin-5, Occludin), alleviated acute brain edema and then recovered neurological dysfunction. Echocardiography and PSR indicated that activation of α7nAChR ameliorated cardiac dysfunction. Western Blot showed that activation of α7nAChR increased autophagy protein (LC3, Beclin) and decreased P62. It demonstrated that the activation of α7nAChR promotes autophagy and then recovers brain and heart function after ICH.ConclusionsIn conclusion, PNU-282987 promoted the cerebral and cardiac functional outcomes after ICH in mice through activated α7nAChR, which may be attributable to promoting autophagy and then reducing inflammatory reactions after ICH.
Development and Verify of Survival Analysis Models for Chinese Patients With Systemic Lupus Erythematosus
Authors: Geng Linyu , Qu Wenqiang , Liang Jun , Kong Wei , Xu Xue , Pan Wenyou , Liu Lin , Wu Min , Ding Fuwan , Hu Huaixia , Ding Xiang , Wei Hua , Zou Yaohong , Qian Xian , Wang Meimei , Wu Jian , Tao Juan , Tan Jun , Da Zhanyun , Zhang Miaojia , Li Jing , Zhang Huayong , Feng Xuebing , Chen Jiaqi , Sun Lingyun 
Published: June 2022

BackgroundThe aim of this study is to develop survival analysis models of hospitalized systemic lupus erythematosus (h-SLE) patients in Jiangsu province using data mining techniques to predict patient survival outcomes and survival status.MethodsIn this study, based on 1999–2009 survival data of 2453 hospitalized SLE (h-SLE) patients in Jiangsu Province, we not only used the Cox proportional hazards model to analyze patients’ survival factors, but also used neural network models to predict survival outcomes. We used semi-supervised learning to label the censored data and introduced cost-sensitivity to achieve data augmentation, addressing category imbalance and pseudo label credibility. In addition, the risk score model was developed by logistic regression.ResultsThe overall accuracy of the survival outcome prediction model exceeded 0.7, and the sensitivity was close to 0.8, and through the comparative analysis of multiple indicators, our model outperformed traditional classifiers. The developed survival risk assessment model based on logistic regression found that there was a clear threshold, i.e., a survival threshold indicating the survival risk of patients, and cardiopulmonary and neuropsychiatric involvement, abnormal blood urea nitrogen levels and alanine aminotransferase level had the greatest impact on patient survival time. In addition, the study developed a graphical user interface (GUI) integrating survival analysis models to assist physicians in diagnosis and treatment.ConclusionsThe proposed survival analysis scheme identifies disease-related pathogenic and prognosis factors, and has the potential to improve the effectiveness of clinical interventions.
Serum Total Bilirubin With Hospital Survival in Adults During Extracorporeal Membrane Oxygenation
Authors: Huang Rui , Shao Min , Zhang Cheng , Fang Ming , Jin Mengmeng , Han Xuan , Liu Nian 
Published: June 2022

BackgroundExtracorporeal membrane oxygenation (ECMO) is widely used for refractory cardiopulmonary failure treatment. The disadvantage of ECMO is its higher risk profile and clinical resource consumption. This observation examines the role of serum total bilirubin (TBIL) as a predictor of adult patient outcomes on ECMO support.MethodsThis retrospective observation reports a single-center experience with adults on ECMO support between 2018 and 2021. Data were collected regarding demographics, ECMO details, laboratory parameters, and outcomes. We examined the elevation of TBIL to predict survival and variables associated with hyperbilirubinemia.ResultsThe patients who died within 28 days had a twofold higher peak level of TBIL than those who survived [73.10 (38.60, 98.64) vs. 34.50 (24.03, 54.85); P = 0.003]. Univariate logistic regression analyses demonstrated that high TBIL was remarkably associated with an elevated risk of 28-day mortality (OR: 7.25; 95% CI: 2.31–25.49; P = 0.001) and total mortality (OR: 5.71; 95% CI: 1.82–20.66; P = 0.001). The TBIL value was 65 μmol/L as the best cut-off value, and the observation group was divided into a high TBIL subgroup (n = 21) or a low TBIL subgroup (n = 39). The demographic and clinical features did not show a difference, whereas Sequential Organ Failure Assessment (SOFA) and APACHE II scores and ALT, AST, and LAC before ECMO initiation correlated with high or low TBIL (P &lt; 0.05). For coagulation function at the time of TBIL peak, the levels of prothrombin time (PT), activated partial thromboplastin time (APTT), prothrombin time activity (PTA), and fibrinogen (FIB) were different between the two subgroups (P &lt; 0.05). The SOFA score was potentially associated with hyperbilirubinemia after ECMO initiation, and the prediction accuracy was 0.800.ConclusionSerum total bilirubin elevation appears after ECMO initiation and correlates with survival, while other markers of liver injury do not. Serum total bilirubin is an easy-to-measure biomarker to be a predictor of survival after ECMO initiation.
Evaluating the Non-conventional Achalasia Treatment Modalities
Authors: Tustumi Francisco 
Published: June 2022

IntroductionAchalasia is a primary esophageal dysmotility disorder. Despite the high volume of studies addressing the conventional treatments for achalasia, few are debated regarding the non-conventional treatments, such as cardiectomy, cardioplasty, endoluminal substances injection (ethanolamine oleate, polidocanol, botulinum toxin), stents, and certain drugs (beta-agonists, anticholinergic, nitrates, calcium channel blockers, and phosphodiesterase inhibitors).MethodsA critical review was performed.ResultsEndoscopic, surgical, and pharmacological treatments were included. A qualitative synthesis was presented.ConclusionNon-conventional therapeutic options for treating achalasia encompass medical, endoscopic, and surgical procedures. Clinicians and patients need to know all the tools for the management of achalasia. However, several currently available studies of non-conventional treatments lack high-quality evidence, and future randomized trials are still needed.
Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study
Authors: Wang Hayson Chenyu , Li Yunzhu , Li Zhujun , Wang Liquan , Li Ziming , Long Xiao 
Published: June 2022

BackgroundMicrocirculation plays a vital role in scleroderma physiopathology and the mechanism of fat survival.ObjectiveThis study aims to assess the blood perfusion change after fat grafting and evaluate the relationship between blood perfusion and fat graft retention in patients with localized scleroderma (LS).MethodsA pilot study was conducted in patients with LS receiving autologous fat grafting (AFG). Fat graft retention measured by magnetic resonance imaging (MRI) analysis and blood flow perfusion measured by laser speckle contrast imaging 6 months postoperatively were noted. PUMC Localized Scleroderma Facial Aesthetic Index was used to assess the improvement of facial aesthetic impairment.ResultsThe fat retention at the 6-month follow-up was 34.56 ± 11.89 percent. At the 6th month of follow-up, the relative blood perfusion at the lesion area was 115.08 ± 14.39 PU, significantly higher than 100.42 ± 10.62 PU at the pre-operation (p = 0.010). The blood perfusion at follow-up increased by an average of 1.15 ± 0.14 times before the operation. No association between the increase in the blood flow perfusions and fat graft retention was found (r = −0.082, p = 0.811).ConclusionLocal blood perfusion in the lesion area relatively increased after AFG, but no direct relationship was found between fat retention and increased blood supply.
Cannabinoid Effect and Safety in Spasticity Following Stroke: A Double-Blind Randomized Placebo-Controlled Study
Authors: Marinelli Lucio , Puce Luca , Mori Laura , Leandri Massimo , Rosa Gian Marco , Currà Antonio , Fattapposta Francesco , Trompetto Carlo 
Published: June 2022

BackgroundNabiximols is a cannabis-based drug to treat spasticity-associated symptoms currently approved for patients with multiple sclerosis only. Cannabinoids are useful in an increasing number of medical conditions but may bear an increased risk for cardiovascular events. SativexStroke is a double-blind randomized placebo-controlled crossover monocentric clinical trial investigating the efficacy and safety of nabiximols in patients with spasticity following stroke.MethodsPatients were treated with nabiximols oromucosal spray or placebo and assessed before and after two phases of 1-month duration each. Cardiovascular safety was assessed before and during the trial. Primary endpoints were changes in spasticity numeric rating scale scores and electromyographic recording of the stretch reflex in affected wrist flexors. Secondary outcome measures were numeric rating scale scores for pain, sleep and bladder function, the number of daily spasms and clinical assessment of spasticity with the modified Ashworth scale. The study was registered with the EudraCT number 2016-001034-10.ResultsBetween May 2, 2018, and February 20, 2020, 41 patients entered the study. Seven patients did not complete the study, so 34 were included in the analysis. Two serious adverse events occurred, but none related to cardiovascular function. Primary and secondary efficacy outcome measures did not change from baseline during nabiximols treatment relative to placebo.ConclusionThis study suggests that nabiximols use is probably safe in stroke patients, therefore cannabinoid usefulness may be further investigated. The lack of nabiximols effect could be related to low pain levels in recruited patients or different spasticity mechanisms between post-stroke and multiple sclerosis patients. Similarly, a beneficial effect of nabiximols could have emerged if more patients with a higher level of spasticity at baseline were recruited.Clinical Trial Registrationhttps://www.clinicaltrialsregister.eu/ctr-search/trial/2016-001034-10/IT.