bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the effect of Modified Intermittent Fasting and Daily Calorie Restriction on sleep quality and anthropometric indices in women with obesity or overweight: Study protocol of a randomized, controlled trial
Authors: Hooshiar Saeedeh Hosseini , Yazdani Akram , Jafarnejad Sadegh 
Published: September 2022

Abstract
Background: Sleep disturbances are common in nearly one-third of adults. Both low quality of sleep and sleep time could be related to increased obesity. An increase in visceral adipose tissue can result in the secretion of inflammatory cytokines. Inflammatory cytokines can lead to disturbance of the sleep-wake rhythm. Therefore, weight loss may improve sleep quality and duration. Intermittent fasting diet as a popular diet reduces body weight and improves anthropometric indices. This study is performed to further investigate the effect of a modified intermittent fasting diet on sleep quality and anthropometric indices.
Methods: This is an open-label randomized controlled trial to evaluate the effect of daily calorie restriction (control) and modified intermittent fasting (intervention) on sleep quality and anthropometric indices in women with obesity or overweight for 8 weeks. 56 participants are classified using stratified randomization based on body mass index (BMI) and age. Then participants are assigned to one of the two groups of intervention or control using the random numbers table. The sleep quality, daytime sleepiness, and insomnia will be evaluated by using the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale, and the Insomnia Severity Index respectively. The primary outcomes are chosen for the study: the difference in sleep quality, daytime sleepiness, insomnia, BMI, fat-free mass (FFM), body fat mass, waist circumference, and waist-to-hip ratio from baseline to 8 weeks. Secondary outcomes are chosen for the study: the difference in hip circumference, the visceral fat area, percent body fat, soft lean mass, skeletal muscle mass, extracellular water ratio, and total body water from baseline to 8 weeks.
Discussion: This study investigates the effect of intermittent fasting intervention compared with daily calorie restriction on sleep quality and anthropometric indices. The information gained will enhance our understanding of fasting interventions, which can be used to improve clinical dietary recommendations. The findings will help to disclose as yet the unknown relationship between diet and sleep quality.
Trial registration: The protocol was registered at the Iranian Registry of Clinical Trials (IRCT20220522054958N3), date of registration: 2022/07/08, https://www.irct.ir/trial/64510
Cavity effect on vertical and horizontal components of Rayleigh wave using 2D and 3D simulation models
Authors: Rahnema Hossein , Jokar Mehdi Hashemi , Momeni Mohammad , Mahboubi Meisam , Mirassi Sohrab 
Published: September 2022

Abstract
The potential risk of subsurface anomalies such as sinkhole and cavity has always been an important issue in geotechnical and geophysical engineering. Subsurface cavities have dissimilar effects on different components of Rayleigh wave in each direction. This paper intends to detect cavity and intrusion in the half-space and layered soil media. Rayleigh (R) wave propagation is analyzed according to the classical Multi-channel Analysis of Surface Waves (MASW) method. 2D and 3D simulations of Surface wave testing were conducted using Finite Element Modeling (FEM) in Abaqus 6.14. The results show the significant effect of the subsurface cavity on the particle motion and radial component of the Rayleigh wave. Cavity location is determined based on the variation of the maximum normalized amplitude for each trace. Furthermore, the perturbation of the elliptic shape above the cavity can help in cavity detection compared with the recorded data before and after the cavity.
Drift velocity partitioning indicates anomalous high westward drift component for the Indian plate during ~65 + 2 Ma
Authors: Bhagat Amarjeet Ramesh , Sangode S. J. , Dongre Ashish 
Published: September 2022

Abstract
Rapid northward drift of the Indian plate after 130 Ma has also recorded significant plate rotations due to the torques resulting from multiple vector force components. Seismic tomography of the Indian Ocean and palaeomagnetic database of the Deccan Traps are used here to constrain drift velocities at different temporal snapshots, resulting into estimates of 263.2 to 255.7 mmyr− 1 latitudinal drift, 234 to 227.3 mmyr− 1 longitudinal drift and 352.2 to 342.1 mmyr− 1 diagonal drift, for the period from ~ 66 to 64 Ma during the Chrons C30n.y–C29n.y. Alternative displacement models suggest active driving forces arising from i) slab pull, ii) ridge push from eastern-, western and southern plate margins, and iii) Reunion plume-push force; in addition to delamination of the lithospheric root during approximately 65 ± 2 Ma. Delamination of the root amplified the buoyancy of the Indian plate in contrast to sudden loading from Deccan basaltic pile that resulted into complex drift dynamics expressed by hyper plate velocities with an anomalous westward drift component of > 342 mmy− 1. Plain Language Summary: Northward drift of India after rifting from Australia-Antarctica around 130 Ma has been well constrained from the marine magnetic anomaly records preserved in the Indian ocean. Except for chron C34n where the magnetic polarity remained constant for an exceptionally longer period of time, we do not find any lapses in the recorded history for the drift of Indian subcontinent. The sea floor acts as a historical record keeper for the plate motions of the past 180–200 Ma. Despite this well-maintained decorum, there appear to be certain events that escape preservation in the global conveyor belt and may not be reflected in the anomaly records. Here, we present a hitherto unnoticed-unreported event during the Deccan Volcanism from magnetic anomaly database; which however, is clearly visible in paleomagnetic data of the Deccan Traps. It is well established that the highest plate velocities that can be achieved by drifting plates range around 180–200 mmyr− 1. However, in the present study based on paleomagnetic data, we present drift rates that are in excess of 300 mmyr− 1. These drift rates result from contemporary existence of multiple plate driving forces that acted with varying intensities on the Indian plate during the Deccan event. Slab pull combined together with plume push, ridge push and lithospheric root delamination propelled the Indian plate at tremendously high velocities which resulted in multiple course corrections within a short span of ~ 1.5 Ma.
Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) Avid Liver Metastases
Authors: Chau Brittney , BS Tariq Abuali , Shirvani Shervin M , Leung David , Feghali Karine A. Al , Hui Susanta , McGee Heather , Liu An , Amini Arya 
Published: September 2022

Abstract
Purpose
Biology-guided radiotherapy (BgRT) is a novel radiation delivery approach utilizing fluorodeoxyglucose (FDG) activity on positron emission tomography (PET) imaging performed in real-time to track and direct radiation. Adequate contrast in FDG activity between the tumor and the background tissue, referred to as the normalized SUV (NSUV), is necessary for optimal functioning of BgRT. This study seeks to characterize the NSUV in patients with liver metastases.
Methods
We reviewed the charts of 50 lung adenocarcinoma patients with liver metastases. The following variables were collected: SUVmax and SUVmean for each liver metastasis, SUVmean and SUVmax at 5 and 10 mm radially from the lesion, and NSUV at 5 mm and 10 mm (SUVmax of the liver metastasis divided by SUV mean at 5 mm at 10 mm respectively).
Results
82 measurable liver metastases were included in the final analysis. The average SUVbackground of liver was 2.26 (95% confidence interval [CI] 2.17–2.35); average SUVmean for liver metastases was 5.31 (95% CI 4.87–5.75), and average SUVmax of liver metastases was 9.19 (95% CI 7.59–10.78). The average SUVmean at 5 mm and 10 mm radially from each lesion were 3.08 (95% CI 3.00-2.16) and 2.60 (95% CI 2.52–2.68), respectively. The mean NSUV at 5 mm and 10 mm were 3.13 (95% CI 2.53–3.73) and 3.69 (95% CI 3.00-4.41) respectively. Furthermore, 90% of lesions had NSUV greater than 1.45 at 5 mm and greater than 1.77 at 10 mm.
Conclusion
This is the first study to comprehensively characterize FDG contrast between the tumor and the background, or normalized SUV (NSUV), in liver metastases in the context of BgRT. Due to the high background SUV normally found in the liver, this work will be valuable for guiding optimization of BgRT for treating liver metastases in the future.
Combining transradial access and a sheathless femoral access for complex iliac artery chronic total occlusions
Authors: Hayakawa Naoki , Kodera Satoshi , Takanashi Keisuke , Ichihara Shinya , Hirano Satoshi , Arakawa Masataka , Inoguchi Yasunori , Kanda Junji 
Published: September 2022

Abstract
Background: The transradial approach (TRA) is a less invasive treatment approach for aortoiliac (AI) lesions than the transfemoral or transbrachial approach. However, this approach has some problems for complex lesions, including the procedural difficulty. We used a bidirectional approach combining the TRA with a sheathless technique for femoral artery (FA) puncture to treat complex AI lesions, as a minimally-invasive approach that is almost equivalent to a single-puncture method. Here, we describe representative cases with AI chronic total occlusion in which the combination of TRA and sheathless technique for FA puncture was extremely useful.
Case presentation: Case 1 was a 71-year-old man with intermittent claudication (IC). Control angiography showed total occlusion of the left common iliac artery (CIA) ostium to distal external iliac artery (EIA). We used an antegrade TRA, and advanced a guidewire into the subintimal space under intravascular ultrasound (IVUS) guidance. With the retrograde wire passing through a micro-puncture and IVUS-guided parallel wiring, we achieved wire externalization. We successfully deployed two nitinol stents to the entire lesion. Case 2 was a 63-year-old man with IC. Control angiography revealed total occlusion of the right CIA ostium to common femoral artery (CFA) with severe calcification. The antegrade wire reached the distal EIA using the TRA, but was prevented from progressing by the calcified CFA occlusion. A 21-G metal needle was used to penetrate the CFA calcification through the distal true lumen and the wire was inserted into the EIA for wire externalization. We successfully deployed three nitinol stents in the CIA to EIA, and dilated a drug-coated balloon in the CFA with hemostasis of the distal puncture site. In both cases, the retrograde puncture site was hemostatic during the procedure and postoperative bed rest was not required.
Conclusions: TRA combined with a sheathless technique from the FA has the potential to treat AI complex lesions in a less invasive manner.
Positron Annihilation and EBSD Studies of Subsurface Zone Created during Friction in Vanadium
Authors: Dryzek Jerzy , Wróbel Mirosław 
Published: September 2022

Abstract
Positron lifetime and electron backscatter diffraction studies were performed on pure vanadium samples subjected to the sliding test. The changes in the microstructure produced in this test extend even to a depth of about 450 µm. As shown by the diffraction of electron backscattering, near this surface, just after starting the sliding test, a tribolayer with refinement randomly oriented grains was formed. The thickness of this layer varies from 8 to 19 µm depending on the sliding conditions and the mean grain size is about 0.2 µm. In this layer, the formation of cracks and debris was observed. Below is an intermediate layer with elongated grains and serrated grain boundaries in which a geometric dynamic recrystallization process has been recognized.
Assessments of optimal timing for combined therapy with axitinib and immune check point inhibitor in a mouse renal cell carcinoma model
Authors: Watanabe Hiromitsu , Matsushita Yuto , Tamura Keita , Motoyama Daisuke , Sugiyama Takayuki , Otsuka Atsushi , Miyake Hideaki 
Published: September 2022

Abstract
Background
Recently, several types of systemic therapy using tyrosine kinase inhibitor (TKI) and immune checkpoint inhibitor (ICI) have been performed for advanced renal cell carcinoma (aRCC) patients; however, the optimal strategy of sequential treatment with these agents has not been well established. The objective of this study was to determine the optimal timing for the introduction of TKI and ICI using a mouse RCC, RenCa model.
Materials and Methods
The effects of combined treatment of TKI and/or ICI with axitinib, anti-mouse programmed death (PD)-1, or PD-ligand 1 (PD-L1) antibody on tumor growth and survival after subcutaneous and intravenous injection of RenCa cells, respectively, were compared according to three different treatment schedules: simultaneous administration, initial axitinib administration, and initial ICI administration. Infiltrating patterns of lymphocytes into tumors after combined treatments were evaluated by immunohistochemical staining.
Results
In both the patients with anti-PD-1 and anti-PD-L1 antibodies, significantly marked inhibitory effects on subcutaneous growth of tumors were observed in the simultaneous and initial ICI administration, but not the initial axitinib administration, compared to those in the control without treatment. Survival intervals of mice after intravenous injection of RenCa cells were significantly longer in the simultaneous and initial ICI administration, but not the initial axitinib administration, compared to the control. Furthermore, both CD8 + to CD3 + and CD8 + to CD11b + T-lymphocyte ratios in subcutaneous RenCa tumors were significantly higher in the simultaneous and initial ICI administration, but not the initial axitinib administration, compared to the control.
Conclusions
Favorable control against aRCC progression may be achieved by administering TKI and ICI simultaneously or ICI followed by TKI.
Transcriptomic and physiological responses of Rhizobium sp. IRBG74 to Sesbania cannabina and rice (Oryza sativa L) rhizosphere
Authors: Ketelboeter Laura , Gordon Alex , Welmillage Shashini , Sreevi Virinchipuram , Paliy Oleg , Gyaneshwar Prasad 
Published: September 2022

Abstract
Purpose
Rhizobium sp. IRBG74 (IRBG74), is a symbiont of Sesbania cannabina and a growth promoting endophyte of rice. Here, we compare the transcriptomic and physiological responses of IRBG74 in the rhizosphere of S. cannabina and rice.
Methods
We used RNA sequencing to determine transcriptomic changes at 12 and 72 hours post inoculation (hpi) in rhizosphere. Upregulation of key pathways was confirmed using β-glucuronidase (GUS) reporter strains and by histochemical and quantitative GUS activity.
Results
Significant changes in transcriptome with S. cannabina were detected at 12hpi but most gene expression changes with rice were observed at 72hpi. Many pathways including Nod factor synthesis, two component systems, ABC transporters, and synthesis of indole acetic acid (IAA) were upregulated whereas translation, RNA degradation, protein export and sulfur metabolism were downregulated with both plants. In contrast, motility and chemotaxis genes were induced specifically with S. cannabina. The upregulation of nod and IAA genes was confirmed using reporter strains. Nod factor synthesis provides competitive advantage for colonization of rice and chemotaxis is required for colonization of S. cannabina but not of rice.
Conclusion
IRBG74 responded to S. cannabina and rice using specific as well as common transcriptional changes. A mutant defective in Nod factor synthesis was outcompeted for rice colonization. Chemotaxis was required for colonization of S. cannabina but not for rice. IAA synthesis by IRBG74 could be a major mechanism of rice growth promotion. These results provide a foundation for further improvement of rhizobial interactions with rice and other cereals.
GLUT4 translocation and dispersal operate in multiple cell types and are negatively correlated with cell size in adipocytes
Authors: Koester Anna M. , Geiser Angéline , Bowman Peter R.T. , Linde Sebastian , Gadegaard Nikolaj , Bryant Nia J. , Gould Gwyn W. 
Published: September 2022

Abstract
The regulated delivery of the glucose transporter, GLUT4, to the surface of adipocytes and muscle is a key action of insulin. This is underpinned by the delivery and fusion of GLUT4-containing vesicles with the plasma membrane. Recent studies have revealed that a further action of insulin is to mediate the dispersal of GLUT4 molecules away from the site of GLUT4 vesicle fusion with the plasma membrane. Although shown in adipocytes, whether insulin-stimulated dispersal occurs in other cells and/or is exhibited by other proteins remains a matter of debate. Here we show that insulin-stimulates GLUT4 dispersal in the plasma membrane of adipocytes, induced pluripotent stem cell-derived cardiomyocytes and HeLa cells, suggesting that this phenomenon is specific to GLUT4 expressed in all cell types. By contrast, insulin-stimulated dispersal of TfR was not observed in HeLa cells, suggesting that the mechanism may be unique to GLUT4. Consistent with dispersal being an important physiological mechanism, we observed that insulin stimulated GLUT4 dispersal is reduced under conditions of insulin resistance. Adipocytes of different sizes have been shown to exhibit distinct metabolic properties: larger adipocytes exhibit reduced insulin-stimulated glucose transport than smaller cells. Here we show that both GLUT4 delivery to the plasma membrane and GLUT4 dispersal are reduced in larger adipocytes compared to their smaller counterparts, supporting the hypothesis that larger adipocytes are refractory to insulin challenge compared to their smaller counterparts, even within a supposedly homogeneous population of cells.
Dynamic Algorithms for Real-time Routing Traceability: Planning and Optimization
Authors: Smaili Yamina , MOUSS Nadia Kinza , AKSA Karima 
Published: September 2022

Abstract
The customer is king! It is a business/marketing concept. The notion of customer-king refers to that of customer satisfaction. The latter makes it possible to retain the customer and, therefore, to ensure regular cash flow on his part. In the COVID-19 pandemic, daily life has changed and revealed the utmost importance of traceability and standardization to effectively monitor people, assets in the healthcare industry, information, and product distribution.Traceability is among the logistics industry concerns. It plays a vital role in the supply chain to guarantee high service quality and thus maintain the luxurious brand image of the company with reduced distribution costs and increased customer satisfaction. Traceability has seen significant use in recent years thanks to the emergence of technologies such as the Internet of Things (IoT), Intelligent Sensors, and Radio Frequency Identification.... These technologies, involved in the fourth industrial revolution, are viewed as powerful and rapidly growing innovative technologies used to meet the customer pain points, offer better visibility, and add more transparency and reliability to product information throughout their life cycles. This paper presents a contribution to the real-time traceability field through the design of algorithms for dynamic vehicle routing problems (DVRP). It provides a methodology for real-time traceability of vehicles and a Plan Consumers Visit PCV intending to achieve the best solution for the re-optimization on-the-fly or online optimization cost delivery. Thus, it chose the most critical problems in logistics that of several vehicles which start from a common distribution center following a well-defined route without exceeding their charging capacity for serving different customers. Through the IoT technology, real-time information about vehicles and customers' requests can be collected and transmitted to the distribution center for analysis and making better decisions. Even updating the delivery planning is available in real-time in case of receiving new sudden requests during the delivery trip.
Pulmonary function during interscalene block vs supraclavicular block: a single-centre, double-blind, randomized, controlled trial
Authors: WANG Jiajia , HOU Xinwei , ZHANG Xiao , WANG Xueting , QIN Weiwei , LI Qiujie , MA Fuguo , SUN Lixin 
Published: September 2022

Abstract
BACKGROUND: The supraclavicular plexus block (SPB) and interscalene plexus block (IPB) have the potential to pulmonary function, the duration of the potential remains uncertain. So, we compared the effect of SPB and IPB on pulmonary function, especially the duration time.
METHODSː Ninety-eight patients were randomly allocated to group I and group S. The IPB and the SPB procedures were performed with ultrasound guidance before anesthesia induction. An investigator recorded the diaphragm mobility and respiratory function test indicators before the block (T0) and at 30 min (T30 min), 4 h (T4), 8 h (T8), and 12 h (T12) after the block. The diaphragmatic paralysis rate was calculated for above timepoint. The VAS, the recovery time for the sensory and motor block, and adverse reactions within 24 hours of administering the block were also recorded.
RESULTSː The recovery times of diaphragm mobility in group I were longer than those in group S. Compared with group I, group S had a significantly lower diaphragmatic paralysis rate during eupnea breathing at T30 min, and T8 after the block. Similarly, group S had a significantly lower diaphragmatic paralysis rate at deep breathing at T30 min, T8 and T12 after the block. The recovery times of FEV1 and FVC in group I were longer than those in group S. The other results were not statistically significant.
CONCLUSIONSː Ultrasound-guided IPB resulted in a longer periods with a suppressive effect on pulmonary function than SPB.
Clinical Trials Registration：17/12/2019, ChiCTR1900028286
Dietary garlic supplementation positively affects the immunological system of juvenile cobia Rachycentron canadum reared in net pens during winter
Authors: Nóbrega Victor Santos Lira da , Rombenso Artur Nishioka , Pedrosa Virgínia Fonseca , Romano Luis Alberto , Sampaio Luís André , Rodrigues Ricardo Vieira 
Published: September 2022

Abstract
The objective of the present study was to evaluate the effect of garlic (Allium sativum) in the diet of juvenile cobia Rachycentron canadum reared in near shore net pens during winter in the coast of Rio de Janeiro (Brazil). Fish (172 ± 19 g and 31.1 ± 1.4 cm) were stocked in 6 cages (n=40 per cage). Two moist diets were prepared, a control diet without garlic and an experimental diet formulated to include 1% dry garlic. Fish were reared on these diets for 68 days, and at the end of the trial. Growth and survival were not affected by garlic inclusion (P>0.05). On the other side, significant differences (P<0.05) were observed for hematological and immunological parameters. The number of monocytes, thrombocytes, and the neutrophil:lymphocyte ratio were higher (P<0.05) in the control compared to the garlic supplemented diet. Whereas lymphocytes counting and phenotypic expression of lymphocyte receptors CD3 and CD4 were higher in diets containing garlic. Supplementation with 1% of garlic in the diet is recommended to boost the immune system and minimize stress of cobia juveniles farmed in near shore net pens during the winter.