bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Additives on the Solubility and Dissolution of Piroxicam From Prepared Hard Gelatin Capsule
Authors: B. H. Al-Khedairy Eman 
Published: September 2022

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of musculo-skeletal and joint disorders. The problem with this drug is its poor solubility in water and hence poor bioavailability after oral administration. In order to improve its solubility and dissolution behavior, hydrophilic additives such as starch, lactose, superdisintegrants including crospovidone (C.P), cross carmellose sodium (CCS), and sodium starch glycolate (SSG) were physically dry mixed with the drug by simple trituration. The improvement in the solubility in 0.1 N HCl was obtained as the amount of starch or lactose increased in the physical mixture, while for superdisintegrants, they further improve the solubility when they are present in small amount and the best improvement was gained with SSG. To study the effect of these additives on the dissolution of the drug, piroxicam capsules were prepared by simple trituration of the drug with starch or lactose or combination of lactose: starch (2:1)by weight with or with out the presence of SSG. The dissolution profiles of these preparations were analyzed using similarity factor f2. Best results were obtained when the drug was triturated with starch and SSG or with acombinaton of lactose: starch (2:1) by weight with SSG . The dissolution profiles of these preparations were similar to that of the marketed Feldene Â® Pfizer 20 mg capsules with f2 74.6 and 80.37 respectively.
Key words: Piroxicam, hydrophilic additives, superdisintegrant
Association of Admission Serum Resistin Level with Acute ST-Segment Elevation Myocardial Infarction in Iraqi Patients
Authors: J.Kadhim Dheyaa , J.Al-Shamma Kassim , G. Hussein Adeeb 
Published: September 2022

Human resistin is an adipokine, with a possible link to coronary heart disease.A few studies were done about resistin in acute phase of ST-segment elevation myocardial infarction (STEMI) especially in Iraqi patients. Accordingly we design a study to investigate the association between resistin concentration and acute phase of STEMI in Iraqi patients.
The present study was carried out at Al-Yarmouk Teaching Hospital from December 2011 until June 2012. Serum resistin levels were measured in 50 patients with acute STEMI (mean age: 58.16 Â± 11.73 years) at the first 12 hours of admission and 34 normal controls (mean age: 53.98 Â± 15.46 years) matched for age, sex and other risk factors.
Resistin level in patients with acute STEMI (13.08 ng/mL) was significantly higher than that of the control group (5.31 ng/mL) (p < 0.0001). The study revealed a significant negative correlation between serum resistin level and serum adiponectin level among patients.
Key words: Resistin, acute ST-segment elevation myocardial infarction, adipokines
Bioequivalence and Pharmacokinetics of Two Formulations of Amlodipine Tablets in Healthy Subjects
Authors: J. Ibraheem Al-Tamimi Jaafar 
Published: September 2022

The bioequivalence of a single dose tablet containing 5 mg amlodipine as a test product in comparison to NorvascÂ® 5 mg tablet (Pfizer USA) as the reference product was studied. Both products were administered to twenty eight healthy male adult subjects applying a fasting, single-dose, two-treatment, two-period, two-sequence, randomized crossover design with two weeks washout period between dosing. Twenty blood samples were withdrawn from each subject over 144 hours period. Amlodipine concentrations were determined in plasma by a validated HPLC-MS/MS method. From the plasma concentration-time data of each individual, the pharmacokinetic parameters; Cmax, Tmax, AUC0-t, AUC0-Â¥, Cmax/AUC0-Â¥, lZ, T0.5, MRT, Cl/F and Vd/F; were calculated applying non-compartmental analysis. The average values of the above parameters for the test formula were 1.99 ng/ml, 8.3 hours, 82.87 ng.hr/ml, 95.23 ng.hr/ml, 0.0219 hr-1, 0.018 hr-1, 38.5 hr, 56.2 hr, 60.9 l/hr and 3483 liters, respectively. The average values of these parameter for the reference formula were 1.92 ng/ml, 7.9 hours, 76.3 ng.hr/ml, 89.31 ng.hr/ml, 0.0225hr-1, 0.019 hr-1, 36.7 hr, 59.9 hr, 69.5 l/hr, and 3983.4 liters, respectively. The pharmacokinetic parameters mentioned above were statistically analyzed by ANOVA test. Ln-transformed values of the pharmacokinetic parameters used for bioequivalence testing; Cmax, AUC0-t and AUC0-Â¥ ; were also statistically analyzed by ANOVA, 90% Confidence Interval (CI) and Schuirmannâ€™s two one-sided t-tests. For the Tmax, parametric and nonparametric tests were applied. Based on FDA criteria on bioequivalence, the results of the above statistical tests demonstrated bioequivalence of the two products.
Keywords: Amlodipine, Pharmacokinetic, Bioequivalence , HPLC/MS/MS.
Detection of Helicobacter Pylori IgG and IgA , Serum Biomarkers CA19-9 and CEA in Patients with Gastrointestinal Diseases
Authors: R. Kadhim Shurooq , H. Alaiwi Ishraq , R. Rasha 
Published: September 2022

Gastrointestinal diseases and especially chronic gastritis are mainly induced by Helicobacter pylori infection, and provides the basis for gastric carcinogenesis and colorectal cancer. The study involved the detection of serum anti-H. pylori IgG and IgA antibody of and some serum biomarkers ;CEA and CA19-9 in patients with gastrointestinal diseases. Fifty eight serum samples were collected from 25 males and 33 females .Peripheral venous blood was collected from each patient and sera obtained by centrifugation. Serum anti-H. pylori IgG and IgA ,serum CEA and CA19-9 were evaluated by enzyme-linked immunoadsorbent assays (ELISA).Forty eight serum samples were positive for IgG (82.7% ) divided into 27 positive samples for females and 21 positive samples for males while ten samples were positive for IgA ( 17.2%) divided into eight positive samples for females and two positive samples for males .Only three samples were positive for anti IgG and serum biomarker CA19-9 .In this study most of positive results of H.Pylori IgA and IgG are between the age 30-50 years and low within 1-10 years ,we conclude because most of them are working and eat fast food from different sources. This study concluded that detection of serum IgG and IgA is effective in monitoring the H. pylori infection in gastrointestinal disorders and chronic infections .
Keywords: Gastrointestinal diseases, Gastritis , H.Pylori, IgG ,IgA ,CEA,CA19-9.
PENINGKATAN AKTIVITAS DAN HASIL BELAJAR PESERTA DIDIK MELALUI PENERAPAN MODEL PREDICT-OBSERVE-EXPLAIN (POE) KELAS XI MIA 3 SMA NEGERI 1 SENDANA
Authors: Sainab Sainab , Rahman Sari Rahayu 
Published: September 2022

Penelitian ini adalah penelitian tindakan kelas yang dilaksanakan dalam dua siklus. Tujuan penelitian ini untuk mengetahui peningkatan aktivitas dan hasil belajar peserta didik dengan diterapkannya model Predict –Observe-Explain (POE) dalam matapelajaran IPA Biologi kelas IX MIA 3 SMAN 1 Sendana pada semester ganjil Tahun ajaran 2019/2020. Subjek penelitian adalah peseta didik kelas XI MIA 3 SMAN 1 Sendana. Teknik pengumpulan data menggunakan metode tes dan non tes melalui lembar observasi. Data yang terkumpul dianalisis dengan teknik analisis deskriptif kualitatif. Hasil penelitian pada siklus I menunjukkan bahwa persentase aktivitas belajar siswa mencapai 47,3% dengan kategori cukup dan hasil belajar diperoleh dengan nilai rata-rata 73,57 dengan ketuntasan belajar klasikal sebesar 63% dengan kategori belum tuntas KKM. Pada siklus II, persentase aktivitas belajar peserta didik meningkat hingga mencapai 82,3% dengan kategori baik dan hasil belajarnya diperoleh nilai rata-rata sebesar 84 dengan ketuntasan belajar klasikal sebesar 93% dengan kategori tuntas KKM. Dari siklus I kesiklus II aktifitas belajar peserta didik meningkat sebesar 35%, hasil belajar meningkat sebesar 9,46 dan ketuntasan belajar klasikal meningkat sebesar 30%. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa model pembelajaran Predict–Observe-Explain (POE) dapat meningkatan aktivitas dan hasil belajar peserta didik kelas XI MIA SMAN 1 Sendana tahun ajaran 2019/2020.
МОДЕЛЮВАННЯ РОБОТИ ТА ВІЗУАЛІЗАЦІЯ СТАНУ СТРІЧКОВОГО КОНВЕЄРА В ПРОГРАМНОМУ СЕРЕДОВИЩІ TIA PORTAL V.15.1 (ПОВІДОМЛЕННЯ 1)
Authors: Слободян Андрій , Макаришкін Денис , Майдан Павло , Соколан Юлія 
Published: September 2022

Загально відомо, що транспортування вантажів на великі відстані є досить важливою ланкою в більшості технологічних процесів на виробництвах. Тому використання конвеєрного транспорту є досить розповсюдженим на сучасному етапі розвитку промисловості, найбільш поширеними є саме стрічкові конвеєри через високу продуктивність та гнучку будову. Для підвищення ефективності праці на підприємствах ставиться задача автоматизації конвеєрного транспорту, розробка системи автоматичного керування (САК) із можливістю контролю в режимі реального часу дозволить реалізувати дистанційне керування стрічковим конвеєром безпосередньо із автоматизованого робочого місця (АРМ) оператора.
В роботі наведено результати моделювання роботи стрічкового конвеєра, виконані в програмному середовищі TIA PORTAL V.15.1. А саме перший етап, створення технологічних об’єктів, що використовуються в якості цифрових двійників для запуску асинхронного двигуна, який розташований на технологічній лінії.
Створення технологічних об’єктів дозволить перевірити правильність роботи маніпулятора в тестовому режимі, визначити та запрограмувати необхідні швидкості та прискорення, місця встановлення та розширені налаштування лічильників, відслідкувати та виключити можливі помилки при запуску в роботу.
Проаналізовано необхідні технологічні параметри, які необхідно задати в цифровому двійнику та відповідно на реальному стрічковому конвеєрі: налаштування головних динамічних параметрів, налаштування самонаведення осі, налаштування часу допуску, налаштування попереднього керування та посилення контролера положення. В подальшому буде розглянуто введення двигуна в експлуатацію в тестовому режимі та розробку необхідної програми для запуску двигуна в реальному технологічному процесі, з наступною візуалізацією технологічної лінії.
Improving Measurement of Public Objective Knowledge About Hazards
Authors: Johnson Branden 
Published: September 2022

Attempts to measure objective knowledge (OK) of publics about hazards have been motivated by such questions as what do people know about the topic and why; whether and how such knowledge affects attitudes and behaviors regarding hazards; and whether a public information campaign changes knowledge or behaviors. These choices vary widely both within risk analysis and in related fields (e.g., science literacy; health literacy). The aim of this Perspective is to suggest that OK can be measured effectively if with several challenges, but that does not happen consistently, and even the best examples could be improved with several steps. After a brief review of variability in the literature in terms of how OK is defined and what outcomes it might be associated with, I review several challenges faced by OK measurement: knowledge sources, content salience, content timing, scale discrimination ability and dimensionality, and response options and scoring. Although the full suite of challenges is of concern, I focus particularly on novel hazards for which the scientific basis for much definition of “objective” knowledge is shifting rapidly, illustrated by the COVID-19 pandemic in the U.S. I conclude with several recommendations for addressing these challenges so that OK can be better measured, and thus theorists and risk communication practitioners can both better grasp when and how OK makes a difference in attitudes and behavior relevant to hazards.
ANALISIS STANDAR PROSES PADA PEMBELAJARAN MATEMATIKA DI KELAS III SDN 4 PAHANDUT
Authors: Shintano Dede , Kartini Nurul Hikmah , Setyawan Dedy 
Published: September 2022

Penelitian ini bertujuan untuk menganalisa standar proses pada pembelajaran matematika di kelas III SDN 4 Pahandut. Pendekatan yang digunakan pada penelitian ini menggunakan kualitatif deskriptif. Sumber data dalam penelitian ini adalah guru kelas III, kepala sekolah, wakil kepala sekolah dan teman sejawat guru.
Pengumpulan data dilakukan dengan cara observasi, untuk memperoleh gambaran proses pembelajaran yang meliputi pengajaran didalam didalam kelas III dan aktifitas peserta didik saat belajar dikelas, wawancara dilakukan untuk memperoleh data-data berupa informasi dari pihak yang menjadi nara sumber dalam penelitian untuk mengetahui bagaimana pengimplementasian standar proses pada mata pelajaran matematika di kelas III, dan dokumentasi dilakukan untuk mendokumentasikan aktivitas pembelajaran yang dilakukan guru dan peserta didik didalam kelas saat sedang melaksanakan proses pembelajaran.
Hasil penelitan menunjukan bahwa dalam perencanaan atau dalam penyusunan Rencana Pelaksanaan Pembelajaran (RPP) semua komponen-komponen yang wajib ada dalam sebuah Rencana Pelaksanaan Pembelajaran (RPP) sudah tersusun dengan rapi. Tetapi dalam pelaksanaannya, guru hanya melaksanakan kegiatan inti dan kegiatan penutup dan melewatkan kegiatan pendahuluan.
SYSTEMATIC LITERATURE REVIEW : PENERAPAN ALGORITMA NAIVES BAYES DALAM SISTEM PAKAR
Authors: Lutfi Muhamad , Surorejo Sarif , Septiana Pinky 
Published: September 2022

Sistem pakar adalah sistem yang berusaha menerapkan pengetahuan manusia ke komputer yang dirancang untuk menunjukkan kemampuan pemecahan masalah seperti pakar. Metode Naïve Bayes merupakan metode yang digunakan dalam penelitian ini. Metode yang digunakan untuk teknik pengumpulan data adalah dengan melakukan studi untuk mengidentifikasi, memvalidasi, mengevaluasi, dan menginterpretasikan studi, literatur, dan laporan yang tersedia. Artikel jurnal yang terkumpul adalah 16 artikel jurnal yang diterbitkan pada periode 2018-2022. Dari berbagai artikel, peneliti mengumpulkan artikel-artikel yang berhubungan dengan kata kunci penelitian ini. sistematis literatur riview yang digunakan dalam mempelajari sistem artikel pakar menggunakan teknik dalam penambangan data dimungkinkan untuk memfilter data mencari informasi.
Epilogue: The Professoriate as Vocation
Authors: Johnson Stephanie L. , VanLaningham Erin 
Published: September 2022

As we cultivate vocation in undergraduates, our own reflection upon academic roles provides new insight concerning the vocation of the professoriate. What does it mean to be a mentor, teacher, colleague, and scholar in the current landscape of higher education and in this cultural climate? How does our training in genre, language, critical analysis, interpretation, and theory assist our understanding of the professoriate as vocation? As teachers and scholars, our commitments to all aspects of the discipline, including its forms, theories and practices, means that we must also regularly examine our own commitments to the profession. In engaging with texts in the classroom as well as in the practice of the public humanities, we cultivate our own possibilities and test what we hear as our vocational calling. This concluding chapter examines how the academic study of literature is a means to renew and inspire the work we do individually and collectively with students, institutions, and communities for the public good.
Electrophysiological, biomechanical, and finite element analysis study of sacral nerve injury caused by sacral fracture
Authors: Xu Zisheng , Jiang Yifei , Mu Weidong , Li Wenlong , Zhang Guanjun , Jiang Shichao , Xu Peng 
Published: September 2022

Background: We aimed to study the mechanism of sacral nerve injury caused by sacral fractures and the relationship between nerve decompression and nerve function.Methods: First, we observed the anatomical features of lumbosacral nerve root region in Sprague-Dawley rats. Next, the rats were divided into the sham, 10 g, 30 g, and 60 g groups for electrophysiological studies on nerve root constriction injury. Then we studied the biomechanical properties of rat nerve roots, lumbosacral trunk, and sacrum. Finally, we established a finite element analysis model of sacral nerve roots injury in rats and determined the correlation between sacral deformation and the degree of sacral nerve roots injury.Result: Anatomical study showed L5 constitutes sciatic nerve, the length of the L5 nerve root is 3.67 ± 0.15 mm, which is suitable for electrophysiological research on nerve root compression injury. After a series of electrophysiological study of L5 nerve roots, our results showed that nerve root function was almost unaffected at a low degree of compression (10 g). Nerve root function loss began at 30 g compression, and was severe at 60 g compression. The degree of neurological loss was therefore positively correlated with the degree of compression. Combining biomechanical testing of the lumbosacral nerve roots, finite element analysis and neuroelectrophysiological research, we concluded when the sacral foramina deformation is &gt;22.94%, the sacral nerves lose function. When the compression exceeds 33.16%, early recovery of nerve function is difficult even after decompression.Conclusion: In this study, we found that the neurological loss was positively correlated with the degree of compression. After early decompression, nerve root function recovery is possible after moderate compression; however, in severe compression group, the nerve function would not recover. Furthermore, FEA was used to simulate nerve compression during sacral fracture, as well as calculate force loading on nerve with different deformation rates. The relationship between sacral fractures and neurological loss can be analyzed in combination with neurophysiological test results.
The ionic salts with super oxidizing ions O2+ and N5+: Potential candidates for high-energy oxidants
Authors: Yang Xinbo , Li Nan , Li Yuchuan , Pang Siping 
Published: September 2022

As an important component of energetic materials, high-energy oxidant is one of the key materials to improve their energy. The oxidizability of oxidant directly determines the intensity of combustion or explosion reaction. It is generally believed that when the nature of reductant is certain, the stronger the oxidizability, the more intense the reaction. Dioxygenyl cation (O2+) and pentazenium cation (N5+) are two kinds of super oxidizing ions, which oxidizability are comparable to that of fluorine. A series of high energetic ionic salts with O2+, N5+ and various anions as active components are designed, and the results show that: 1) Most ionic salts have appropriate thermodynamic stability, high density (up to 2.201 g/cm3), high enthalpy of formation (up to 1863.234 kJ/mol) and excellent detonation properties (up to 10.83 km/s, 45.9 GPa); 2) The detonation velocity value of O2 (nitrotetrazole-N-oxides) and O2B(N3)4 exceed 10.0 km/s, and the detonation pressure exceed 45.0 GPa because of the O2+ salts have higher crystal density (g/cm3) and oxygen balance than that of N5+salts; 3) With a higher nitrogen content than O2+, the N5+ salts have higher enthalpy of formation, which exceed 330 kJ/mol than that of O2+ salts; 4) The linear spatial structure of N5+ leads the salts to reduce their density. Encouragingly, this study proves that these super oxidizing ions have the potential to become high-energy oxidants, which could be a theoretical reference for the design of new high energetic materials.
New adverse coronary events in valve-in-valve TAVR and native TAVR—A 2-year matched cohort
Authors: Koren Ofir , Patel Vivek , Naami Robert , Naami Edmund , Nagasaka Takashi , Shechter Alon , Natanzon Sharon Shalom , Kohan Siamak , Allison Zev , Lerner Addee , Cheng Daniel Eugene , Chakravarty Tarun , Nakamura Mamoo , Cheng Wen , Jilaihawi Hasan , Makkar Raj R. 
Published: September 2022

ObjectiveTo assess the incidence of new adverse coronary events (NACE) following transcatheter aortic valve replacement (TAVR) and valve-in-valve TAVR (ViV-TAVR).BackgroundViV-TAVR is an accepted treatment for degenerative prostheses among patients with high surgical-risk. TAVR studies have suggested an increased risk of coronary artery obstruction and flow stasis causing thrombus formation. Whether contemporary ViV-TAVR is associated with higher rate of coronary events compared to TAVR is unknown.MethodsWe used data from 1,224 TAVR patients between 2016 and 2021. We propensity-matched patients following ViV-TAVR and TAVR by significant predictors to overcome confounders in patients' baseline characteristics and procedural factors.ResultsThe matched population included 129 patients in each group. In line with prior reports, there was a higher in-hospital coronary artery obstruction rate with ViV-TAVR (3.1 vs. 1.6%; p = 0.23). Despite this, 2-year cumulative NACE rates were similar between groups (4.7 vs. 6.2%, respectively, p = 0.79), with no difference between its components: myocardial infarction (MI) (p = 0.210), unplanned coronary catheterization (p = 0.477), or coronary artery bypass grafting (CABG) (p = 0.998). Moreover, hypoattenuated leaflets thickening (HALT) at 30-day CT was observed in nearly a quarter of the patients with no difference between groups (23.9 vs. 23.1%, HR 1.02, 95% CI 0.50–1.28, p = 0.872). The progression rate of the coronary artery calcium score (CACS), assessed in a third of patients, was similar between groups (p log-rank = 0.468, 95% CI 0.12–1.24). Low coronary artery height was an unfavorable predictor for in-hospital coronary obstruction and 2-year NACE rate (HR 1.20 and HR 1.25, p = 0.001 and p &lt; 0.0001, respectively).ConclusionAt 2-year follow-up, ViV-TAVR was not associated with a higher rate of myocardial infarction, unplanned catheterization, coronary artery bypass grafting, or hypoattenuated leaflet thickening.
Twenty-four hour variability of inverted T-waves in patients with apical hypertrophic cardiomyopathy
Authors: Ma Fei , Yang Yating , Tao Jingwen , Deng Xiaoyan , Chen Xufeng , Fan Jingjing , Bai Xuelei , Dai Tongyu , Li Sheng , Yang Xiaoyun , Lin Fan 
Published: September 2022

BackgroundPatients with apical hypertrophic cardiomyopathy (ApHCM) have marked inverted T-waves that vary over several years. Inverted T-waves in ApHCM are unstable, but it is unclear whether this change is due to coronary artery disease (CAD) or if it is a characteristic of ApHCM itself. We aimed to study the characteristics of inverted T-waves in patients with ApHCM over the course of 24 h to improve the diagnostic indices of ApHCM.MethodsWe examined 83 patients with ApHCM and 89 patients with CAD (who served as the control group). All patients underwent a 24-h dynamic electrocardiogram (ECG). We analyzed the average depth of inverted T-waves per minute and sorted them from shallow to deep; the sorted ECG segments at the 10th, 50th, and 90th positions of the T-wave were subsequently analyzed.ResultsThe amplitudes of inverted T-waves in ApHCM corresponding to the 10th, 50th, and 90th percentiles were −5.13 ± 4.11, −8.10 ± 4.55, and −10.9 ± 5.04 mm, respectively. Changes in the degree of inverted T-waves were greater in ApHCM than in CAD. T-wave amplitudes in ApHCM were strongly associated with heart rate and circadian rhythm and only weakly associated with CAD and posture. Maximum T-wave amplitudes in the CAD group were &lt;10 mm, while 68% of patients with ApHCM had maximum T-wave amplitudes &gt;10 mm, and all patients with ApHCM aged &lt;50 years had maximum T-wave amplitudes &gt;10 mm.ConclusionNotable variations in the T-waves of patients with ApHCM were observed over 24 h. ECG examinations during states of inactivity (comparable to sleep) improved the sensitivity of the diagnosis of ApHCM. Inverted T-wave amplitudes correlated with heart rate and circadian rhythm, where T-wave changes in ApHCM may be due to the normalization of abnormal T-waves effect. Identifying T-wave amplitudes &gt;10 mm can effectively improve the diagnostic rate of ApHCM, especially in patients aged &lt;50 years. The short-term change in T-waves in patients with ApHCM could serve as a novel index that will help in the diagnosis of ApHCM.