bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building an ecosystem brand
Authors: Krippendorff Kaihan 
Published: September 2022

Purpose
At Haier, one of the world’s largest suppliers of kitchen appliances, an initiative successfully transformed a culinary innovation into a novel ?ecosystem brand? ? a rapidly emerging economic model that is disrupting industries from entertainment and electronics to aviation and IT.

Design Methodology Approach
In addition to attracting and engaging users/ customers and employees, the brand must now be effective with a third stakeholder group: ecosystem partners.

Findings
Without a brand that attracts ecosystem partners an ecosystem will not exist.

Practical Implications
Ecosystems use a variety of mechanisms and processes to encourage adherence to a consistent brand.

Originality Value
Because ecosystem companies can continuously customize their offering by configuring the individual value of ecosystem partners in new ways they can compete. in a new way
Share and embrace demographic and location diversity: Creating an Instagram‐based inclusive online learning community
Authors: Zhu Wangda , Hua Ying , Zhu Gaoxia , Wang Luping 
Published: September 2022

AbstractIt is critical to create an inclusive online learning environment for students with diverse demographic information studying in different environments, especially during the COVID‐19 pandemic when they are disconnected from peers. Guided to create an inclusive online learning community by situated learning theory and community of practice, both of which advocate learning in context and community, we invited 115 undergraduate students to post photos related to environmental psychology concepts and their surrounding environments and discussed their postings on Instagram over eight weeks. To understand the inclusiveness of the community and students' perception, we collected their posts by searching designated hashtags and interviewed representatives of participants using a stratified sampling strategy. Through network analysis of 272 posts and qualitative analysis of 22 in‐depth interviews, we found that when participants shared and discussed their surroundings and environmental psychology concepts on Instagram, their learning community was inclusive regarding gender, ethnicity, and program. Student participants' centrality and influence were more relevant to whether and how they expressed their identities in the community through posts. We further discuss how our findings could inform to create inclusive and active communities in the future.
Practitioner notesWhat is already known about this topic?

The definition of inclusive education extends to diversity and accessibility.
Social media can support online learning communities.
What this paper adds?

It explores the inclusiveness of an Instagram‐based learning community using network analysis.
It suggests expressing identities in a learning community helps promote inclusiveness.
Implications of this study for practice and/or policy

It provides information to education practitioners that will help them create inclusive and active communities through social media.
It explores the possibility of analysing the inclusiveness of a learning community through social network analysis.
Exploring proteomic plasma biomarkers in eosinophilic and neutrophilic asthma
Authors: Kere Maura , Klevebro Susanna , Hernandez‐Pacheco Natalia , Ödling Maria , Ekström Sandra , Mogensen Ida , Janson Christer , Palmberg Lena , van Hage Marianne , Georgelis Antonios , Bergström Anna , Kull Inger , Melén Erik , Björkander Sophia 
Published: September 2022

AbstractBackgroundFew biomarkers identify eosinophilic and neutrophilic asthma beyond cell concentrations in blood or sputum. Finding novel biomarkers for asthma endotypes could give insight about disease mechanisms and guide tailored treatment. Our aim was to investigate clinical characteristics and inflammation‐related plasma proteins in relation to blood eosinophil and neutrophil concentrations in subjects with and without asthma.MethodsWe included 24–26‐year‐old subjects (n = 2063) from the Swedish population‐based cohort BAMSE. Subjects with asthma (n = 239) and without asthma (n = 1824) were subdivided based on blood eosinophil and neutrophil concentrations (cut‐offs 0.3 × 109/L and 5.0 × 109/L, respectively). We measured the levels of 92 plasma proteins using Olink Proseek Multiplex Inflammation Panel Assay. Group statistics tests were used to analyse the data, as well as adjusted multiple logistic regression models.ResultsAmong subjects with asthma, 21.8% had eosinophilic asthma and 20.5% neutrophilic asthma. Eosinophilic asthma, but not neutrophilic asthma, was associated with a distinct clinical phenotype with, for example, higher proportions of eczema and sensitization. Most plasma proteins that associated with high eosinophil and/or neutrophil blood concentrations in subjects with asthma showed similar associations in subjects without asthma. However, out of these proteins, MMP10 levels were associated with eosinophilic asthma and were significantly higher as compared to controls with high eosinophilic concentration, while CCL4 levels associated with high neutrophil concentration only in subjects with asthma.ConclusionsEosinophilic asthma was associated with a clear clinical phenotype. With our definitions, we identified MMP10 as a possible plasma biomarker for eosinophilic asthma and CCL4 was linked to neutrophilic asthma. These proteins should be evaluated further in clinical settings and using sputum granulocytes to define the asthma endotypes.
Analysing sinonasal microbiota of fungal rhinosinusitis by next‐generation sequencing
Authors: Huang Yu‐Wen , Wang Wei‐Hsin , Lan Ming‐Ying 
Published: September 2022

AbstractObjectivesFungal rhinosinusitis is an inflammatory disease of the nose that may lead to life‐threatening complications. This study compared the bacterial and fungal microbiomes between patients with invasive fungal rhinosinusitis (IFRS) and non‐IFRS (NIFRS).DesignThis was a prospective study including 18 IFRS and NIFRS patients. Fungal and bacterial microbiomes from surgical specimens were sequenced from amplicons of the internal transcribed spacer 1 (ITS1) region and the V3–V4 region of the 16S locus, respectively. Microbiomes were generated using the Illumina MiSeq System 2 x 301 base pair chemistry with a paired‐end protocol.SettingTertiary medical centre.ResultsTargeted metagenomics identified Aspergillus spp. as the predominant fungus in both IFRS and NIFRS patients. Based on phylum and genera level diversity, and abundance differences, significant differences of operational taxonomic units (OTUs) (Fusobacterium, Prevotella, Pseudomonas, Neisseria and Streptococcus) were more abundant in NIFRS compared with IFRS patients.ConclusionsThis is the first study to analyse bacterial and fungal microbiomes in patients with IFRS and NIFRS via ITS1 and 16S genomics sequencing. Bacterial microbiomes from patients with IFRS demonstrated dysbiosis (alterations in diversity and abundance) compared to those from patients with NIFRS.
Endoscopy and MRI for restaging early rectal cancer after neoadjuvant treatment
Authors: Stijns Rutger C. H. , Leijtens Jeroen , de Graaf Eelco , Bach Simon P. , Beets Geerard , Bremers Andre J. A. , Beets‐Tan Regina G. H. , de Wilt Johannes H. W. 
Published: September 2022

AbstractAimChemoradiotherapy (CRT) has great potential to downstage rectal cancer. Response assessment has been investigated in locally advanced rectal cancer but not in early stage rectal cancer. The aim is to characterize the diagnostic accuracy of endoscopy performed by surgical endoscopists compared to (diffusion‐weighted, DWI) MRI only and a multimodal approach combining (DWI‐)MRI and endoscopic information both analysed by an abdominal radiologist for response assessment in early rectal cancer after neoadjuvant CRT.Materials and methodsPatients treated with neoadjuvant CRT for early distal rectal cancer (cT1–3 N0) followed by transanal endoscopic microsurgery were included. Three separate reassessment groups were analysed for response assessment using endoscopic evaluation alone versus (DWI‐)MRI alone versus the combination of endoscopy with (DWI‐)MRI with a focus on sensitivity and specificity and analysis using receiver operating characteristic curves.ResultsThree cohorts (N = 36, N = 25 and N = 25, respectively) were analysed for response assessment. Of the endoscopy cohort, 16 of the 36 patients had a complete response. Area under the curve was 0.69 (0.66–0.74; pooled sensitivity 55.3%, pooled specificity 80.0%). Agreement for scoring separate endoscopic features was poor to moderate. Of the (DWI‐)MRI cohort, 11 of the 25 patients had a complete response. Area under the curve for (DWI‐)MRI alone was 0.55 (sensitivity 72.7%, specificity 42.9%). The areas under the receiver operating characteristic curve improved to 0.68 (sensitivity 90.9%, specificity 75.0%) when (DWI‐)MRI was combined with endoscopic information, with 11 out of 25 patients with a complete response. The most accurate response assessment was made by combining endoscopy and (DWI‐)MRI with a high negative predictive value (90.9%).ConclusionGood and complete responders after chemoradiation of early stage rectal cancer can be best assessed using a multimodality approach combining endoscopy and (DWI‐)MRI.
Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling
Authors: Tu Qing , Li Yi , Zhu Jiali , Guo Long , Liu Chenchen , Liu Lu , Yuan Yuan , Zou Yun , Chen Feng , Yao Liangfang , Li Jinbao 
Published: September 2022

AbstractBackgroundMitochondrial DNA (mtDNA) is a potent activator for pro‐inflammatory response. Dendritic cells (DCs) are immunosuppressed in sepsis, whether mtDNA mediates immunoparalysis in sepsis remains unknown.MethodsThe mRNAs were assessed by qPCR. Flow cytometry was used to measure the expression of costimulatory molecules and the proliferation of CD4+ T cells. Western blot and immunofluorescence staining were used to analyse the expression of proteins. Cytokine secretion was detected by ELISA. Histology of lung tissue was used to assess the inflammatory injury.ResultsLipopolysaccharide‐induced endotoxemia increased plasma mtDNA levels and immunoparalysis of spleen DCs, while hydrolysing mtDNA reversed immunoparalysis of spleen DCs in vivo. Moreover, cytoplasmic mtDNA of DCs was accumulated in endotoxemia and sepsis. mtDNA transfection into bone marrow‐derived DCs (BMDCs) inhibited the expression of costimulatory molecules (e.g., CD40, CD80 and CD86) and the release of IL‐12p70, while increasing the secretion of IL‐10. Cytoplasmic mtDNA also inhibited the ability of BMDCs to promote the proliferation of CD4+ T cells. Mechanistic analysis revealed that STING signalling was required for mtDNA‐mediated immunoparalysis of DCs in vivo and in vitro. Further studies showed deletion of STING reversed mtDNA‐mediated immunoparalysis of DCs and improved the prognosis of endotoxemia and sepsis.ConclusionOur results demonstrated that mtDNA promotes immunoparalysis of DCs, and contributes to sepsis‐associated immunosuppression by activating STING signalling. Our study may provide new insights to elucidate the molecular pathogenesis of immunosuppressive DCs in sepsis.
Mendelian randomization identifies age at menarche as an independent causal effect factor for gestational diabetes mellitus
Authors: Lu Likui , Wan Bangbei , Sun Miao 
Published: September 2022

AbstractAimsThe relationship between age at menarche (AAM) and gestational diabetes mellitus (GDM) risk is still inconclusive. This Mendelian randomization (MR) analysis was used to assess systematically the causal relationship between AAM and GDM risk in human beings.Materials and MethodsSingle‐nucleotide polymorphisms associated with AAM, oestradiol levels, sex hormone‐binding globulin (SHBG) levels and bioavailable testosterone (BioT) levels were screened via the genome‐wide association study enrolling individuals of European descent. Summary‐level data for GDM (123 579 individuals) were extracted from the UK Biobank. An inverse‐variance‐weighted method was used for the primary MR analysis. Sensitivity analyses were examined via MR‐Egger regression, heterogeneity tests, pleiotropy tests and leave‐one‐out tests. The directionality that exposure causes the outcome was verified using the MR‐Steiger test.ResultsGenetically predicted early AAM was found to have a causal positive association with a higher risk of GDM (odds ratio = 0.798, 95% confidence interval = 0.649‐0.980, p = .031). In the multivariable MR analysis adjusted for oestradiol, SHBG and BioT levels, the causal association between AAM and GDM risk remained (odds ratio = 0.651, 95% confidence interval = 0.481‐0.881, p = .006). A 1‐SD increase in SHBG or BioT levels was significantly associated with a 41.4% decrease or 20.8% increase in the overall GDM risk (p = 3.71E‐05 and .040), respectively. However, after controlling for AAM, oestradiol levels and BioT levels by multivariable MR analysis, there was no direct causal effect of SHBG levels on GDM risk (p = .084). Similarly, after adjusting for AAM, oestradiol levels and SHBG levels by multivariable MR analysis, there was no direct causal effect of BioT levels on the risk of GDM (p = .533). In addition, no direct causal association was identified between oestradiol levels and GDM risk in univariable MR analysis or multivariable MR analysis.ConclusionGenetic variants predisposing individuals to early AAM were independently associated with higher GDM risk. Further research is required to understand the mechanisms underlying this putative causative association. In addition, AAM may be helpful in clinical practice to identify women at risk for GDM; pregnant women who are young for menarche may need to take precautions before GDM develops.
Multiaxial fatigue life prediction by equivalent energy‐based critical plane damage parameter under variable amplitude loading
Authors: Tao Zhi‐Qiang , Qian Guian , Sun Jingyu , Zhang Zi‐Ling , Hong Youshi 
Published: September 2022

AbstractA new path‐independent multiaxial fatigue damage parameter
, which is defined as the largest normal stress range between adjacent turning points of the maximum shear stress on the critical plane, is proposed to describe multiaxial fatigue damage. By combining the maximum normal stress
or the largest normal stress range
with the maximum shear stress range on the critical plane, two axial equivalent stress modification factors,
and
, are proposed, which can account for the influence of non‐proportional additional hardening. The sensitivity of the proposed axial equivalent stress modification factors to multiaxial variable amplitude loading sequences is analyzed. Furthermore, two new multiaxial fatigue damage models based on the axial equivalent stress modification factors are proposed to estimate fatigue life. The applicability of the presented methodology was verified by the experimental data of En15R steel and 7050‐T7451 aluminum alloy, and the results showed that the predicted fatigue lifetimes agree well with the experimental data under variable amplitude multiaxial loading.
Worldwide impacts of landscape anthropization on mosquito abundance and diversity: A meta‐analysis
Authors: Perrin Antoine , Glaizot Olivier , Christe Philippe 
Published: September 2022

AbstractIn recent decades, the emergence and resurgence of vector‐borne diseases have been well documented worldwide, especially in tropical regions where protection and defense tools for human populations are still very limited. In this context, the dynamics of pathogens are influenced by landscape anthropization (i.e., urbanization, deforestation, and agricultural development), and one of the mechanisms through which this occurs is a change in the abundance and/or diversity of the vectors. An increasing number of empirical studies have described heterogeneous effects of landscape anthropization on vector communities; therefore, it is difficult to have an overall picture of these effects on a global scale. Here, we performed a meta‐analysis to quantify the impacts of landscape anthropization on a global scale on the presence/abundance and diversity of mosquitoes, the most important arthropods affecting human health. We obtained 338 effect sizes on 132 mosquito species, compiled from 107 studies in 52 countries that covered almost every part of the world. The results of the meta‐analysis showed an overall decline of mosquito presence/abundance and diversity in response to urbanization, deforestation, and agricultural development, except for a few mosquito species that have been able to exploit landscape anthropization well. Our results highlighted that these few favored mosquito species are those of global concern. They, thus, provide a better understanding of the overall effect of landscape anthropization on vector communities and, more importantly, suggest a greater risk of emergence and transmission of vector‐borne diseases in human‐modified landscapes.
A 16S rRNA amplicon approach to the structural and functional diversity of bacterial communities associated with horse gram crop for drought mitigation and sustainable productivity
Authors: Evangilene Shirley , Uthandi Sivakumar 
Published: September 2022

Abstract

Aim
In this study, 16S rRNA amplicon sequencing analyses were performed to determine the diversity of the bacterial community present in the soil, rhizosphere region, root nodules and seeds of the horse gram plant.

Methods and Results
We observed the dominance of Proteobacteria, Actinobacteria, Firmicutes, Acidobacteria, Bacteroidetes, Planctomycetes and Gemmatimonadetes across all four domains of the horse gram plant. For community analyses, the significance of the alpha diversity was estimated using the Shannon index, Simpson index and Chao1 index, which revealed no significant difference among the samples. However, the estimation of the beta diversity indicated a significant difference among the samples, with p &lt; 0.001 and R2 = 1. A strong positive correlation was found between the rhizosphere and root nodule samples. Comparative genomics of the 16S rRNA gene showed that ammonium-oxidizing metabolism (amoA), nitrite-reducing metabolism (nirK) and nitrogen-fixing metabolism (nifH) were prominent mechanisms in all samples. The genes involved in the biosynthesis of amino acids, purine metabolism and nitrogen metabolism were identified as the key genes associated with the functional traits of microbial domains in horse gram.

Conclusion
The culturable microbes associated with horse gram can be used as a substitute for synthetic fertilizers to maintain soil fertility and ecological health in agricultural practices.

Significance and Impact of the study
Determining the survival strategies of bacterial communities that positively respond to multiple gate selection helps in understanding the structural diversity and functional traits primarily focused on the development of beneficial microbial consortium for promoting plant growth.
Agency and vulnerability in the field of immigration law: a linguistic‐ethnographic perspective on lawyer–client interaction
Authors: JACOBS MARIE , MARYNS KATRIJN 
Published: September 2022

AbstractMigrants are often perceived as a group of vulnerable victims, especially within a legal context such as the one in this study: lawyer–client consultations in the field of immigration law. The literature describes how institutional limitations often translate into asymmetric lawyer–client dynamics. The linguistic‐ethnographic data gathered for this study shows, however, that the reality is more complex. In operationalizing the concept of agency, this study focuses on the dynamic‐relational nature of power differences, which implies a move away from the binary conceptualization of structure and agency. The ethnographic lens helps to unpack agency and reveals a picture of strategic behaviour that is contextually embedded and multi‐layered. In this light, the performance of agency and vulnerability is shown to be (1) interactionally achieved, (2) indicative of an awareness of macro‐level processes, and (3) reflective of the philosophy behind the authorities’ migration management.
Dialecticism in romantic relationships: An examination in Chinese and American cultural contexts
Authors: Lam Ben C. P. , Cross Susan E. , Chen Sylvia Xiaohua , Au Algae K. Y. , Ng Jacky C. K. , Zhang Jin‐lin , Zheng Li‐jun 
Published: September 2022

AbstractThe cultural theory of naïve dialecticism, denoting Chinese lay beliefs about expectation of change and tolerance of contradiction, was employed to examine Chinese and European Americans' representation and evaluation of their romantic partners and relationships across three studies. We found that Chinese were more likely than Euro‐Americans to spontaneously describe their partners with contradictory attributes (Study 1). While Chinese and Euro‐Americans organized their evaluative partner knowledge in equally compartmentalized ways, Chinese were more likely to hold complex knowledge structures and to value both positive and negative partner knowledge (Study 2). Moreover, Chinese were more likely than Euro‐Americans to simultaneously hold positive and negative attitudes toward their partner and relationship (i.e., being ambivalent), both implicitly and explicitly (Study 3). These findings illuminate theories and research on contradictions in intimate relationships from a cultural perspective.
Robotic‐assisted bronchoscopy versus CT‐guided transthoracic biopsy for diagnosis of pulmonary nodules
Authors: Yu Lee‐Mateus Alejandra , Reisenauer Janani , Garcia‐Saucedo Juan C. , Abia‐Trujillo David , Buckarma EeeLN H. , Edell Eric S. , Grage Rolf A. , Bowman Andrew W. , Labarca Gonzalo , Johnson Margaret M. , Patel Neal M. , Fernandez‐Bussy Sebastian 
Published: September 2022

AbstractBackground and ObjectiveCurrently, computed tomography‐guided transthoracic biopsy (CTTB) is the most accurate diagnostic approach for pulmonary nodules suspected of malignancy. Traditional bronchoscopy has shown suboptimal diagnostic sensitivity, but the emergence of robotic‐assisted bronchoscopy (RAB) has the potential to improve diagnostic accuracy, maximize diagnostic yield and complete mediastinal and hilar staging in a single procedure. We aim to assess the efficacy and diagnostic performance of RAB compared to CTTB for diagnosing pulmonary nodules suspected of lung cancer.MethodsA multicenter retrospective review of consecutive patients who underwent RAB and CTTB for evaluating pulmonary nodules from January 2019 to March 2021 at Mayo Clinic Florida and Mayo Clinic Rochester, United States. Clinical and demographic information, nodule characteristics, outcomes and complications were compared between RAB and CTTB.ResultsA total of 225 patients were included: 113 in the RAB group and 112 in the CTTB group. Overall diagnostic yield was 87.6% for RAB and 88.4% for CTTB. For malignant disease, RAB had a sensitivity of 82.1% and a specificity of 100%, CTTB had a sensitivity of 88.5% and a specificity of 100%. Complication rate was significantly higher for CTTB compared to RAB (17% vs. 4.4%; p = 0.002).ConclusionRAB, when available, can be as accurate as CTTB for sampling pulmonary nodules with similar or reduced complications and should be considered as a means for nodule biopsy, particularly when mediastinal staging is also clinically warranted.