bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation and cross-cultural adaptation of the Air Medical Prehospital Triage (AMPT) Score for Helicopter Transport of Trauma Patients to Brazilian Portuguese
Authors: Alvim-Oliveira Roges , Bernardes-Oliveira Camila L. , Reis Aline S. , Brown Joshua B. , Sá-Caputo Danúbia C. , Bernardo-Filho Mario 
Published: June 2022

Introduction: The transport of patients by airplanes or helicopters reduces treatment time, while improving the chances of survival and the quality of life. Due to its costly maintenance and operation service, the air transport of victims depends on appropriate triage criteria for patients eligible for this type of transport. The Air Medical Prehospital Triage (AMPT) Score for Helicopter Transport of Trauma Patients quickly classifies the likelihood of trauma victims benefiting or not from helicopter transport. Objectives: The aim of this study was to translate the AMPT Score and cross-culturally adapt it to Brazilian Portuguese. Methods: This study followed international guidelines for standardized translation processes and was developed from: translation, synthesis, back translation, assessment of equivalences by the expert committee, proposal of the previous version of AMPT Score, application of pre-test/post-test and proposition of the final version of the translated scale. Results: The Wilcoxon Test comparing the experts’ assessment with the positive expected resulted in a p-value = 0.0625 (General) CI 95%. The Content Validity Index (CVI) of the experts committee was calculated as 0.9479. The pre-test data resulted in a Cronbach’s Alpha of 0.920 ± 7.26. The free-marginal Kappa coefficient of pre-test data was 0.89 (95% CI for 0.86, 0.93).The post-test data resulted in a Cronbach’s Alpha of 0.925 ± 5.36. The Wilcoxon Test comparing pre-test with post-test resulted in a p-value of 0.0942. Conclusions: The process resulted in a translation of the AMPT Score with the appropriate equivalences proposed by the literature that is statistically reliable and will be of great value to professionals who work with transporting trauma victims in helicopters. Keywords: Prehospital care; Air ambulances; Helicopter; Triage; Translation.
Apoptosis in myelodysplasia: Association with patient age, bone marrow cellularity and karyotypes
Authors: De Souza Daiane C. , Camargo Adriana C. , Rodrigues Eliane F. , Campos Mércia M. , Alvarenga Tatiana F. , Fernandez Cecília De S. , Da Costa Elaine S. , Fernandez Teresa De S. 
Published: June 2022

Background: Myelodysplastic syndrome (MDS) comprises a heterogeneous group of clonal hematopoietic stem cell diseases, characterized by dysplasias and apoptosis in bone marrow (BM) and cytopenias in peripheral blood. In this study, we analyzed apoptosis in MDS to verify associations with patient age, bone marrow cellularity and karyotypes and to investigate the role of apoptosis in MDS pathogenesis. Methods: Bone marrow cells were collected from 81 patients with primary MDS, of which 60 were adults and 21 children. BM cells were also collected from 10 healthy donors for bone marrow transplants, 5 adults and 5 children, as controls. The patients and controls came from public onco-hematology institutions in Rio de Janeiro. The percentage of apoptotic BM cells was assessed by flow cytometry using two combinations: annexin V-FITC/CD34PE/CD45PerCP and annexin V-FITC/CD14PE/CD45PerCP in BM cells. Cytogenetic analysis was performed by G-banding. Results: The comparison between adult and pediatric patients showed that these patients show a similar behavior with regard to apoptotic cells percentages in BM samples. Apoptosis occurs independently of BM cellularity, being more prominent in patients with hyper/normocellular BM. Patients with normal karyotypes, del(5q), del(17p) had higher apoptosis rates than patients with del(11q) and complex karyotypes. Cells committed to a differentiation program were associated with high rates of apoptosis, suggesting that apoptosis may be a consequence of inefficient hematopoiesis, such that the hematopoietic system may eliminate dysplastic cells at the beginning of the disease. Conclusions: Our results suggest that apoptosis is an important characteristic of BM cells from adult and pediatric MDS patients and may be a consequence of inefficient hematopoiesis. In addition, we suggest that apoptosis is not the main mechanism associated with hypocellular MDS, and it occurs preferentially in MDS cases of hyper/normocellular BM and is associated with a good prognosis. Keywords: Myelodysplastic Syndrome; Apoptosis; Patient age; Bone marrow cellularity; Karyotypes.
How does hip and knee arthroplasty affect golfer performance and what should be expected regarding return to play?
Authors: Hoggett Lee , Frankland Samuel , Ranson John , Nevill Chris , Hughes Pete 
Published: June 2022

Aims Hip and knee arthroplasty is commonly performed for end-stage arthritis. There is limited information to guide golfers on the impact this procedure will have postoperatively. This study aimed to determine the impact of lower limb arthroplasty on amateur golfer performance and return to play. Methods A retrospective observational study was designed to collect information from golfers following arthroplasty. Data were collected from 18 April 2019 to 30 April 2019 and combined a patient survey with in-app handicap data. Results A total of 2,198 responses were analyzed (1,097 hip and 1,101 knee). Of the respondents, 1,763 (80%) were male and the mean age was 70 years (26 to 92). Hip arthroplasty was associated with a mean increase in handicap of 1.03 (95% confidence interval (CI) 0.81 to 1.25). No difference was seen between isolated leading or trailing leg (p = 0.428). Bilateral hip arthroplasty increased handicap (p < 0.001). Overall, 1,025 (94%) maintained or increased the amount of golf played, 258 (23.5%) returned to iron shots at six weeks, 883 (80%) returned to club competitions at six months, 18 (1.6%) had persistent pain, and 19 (1.7%) were unable to return to play. Knee arthroplasty was associated with a mean increase in handicap of 1.18 (95% CI 0.99 to 1.38). Trailing leg arthroplasty alone was associated with higher postoperative handicap (p = 0.002) as was bilateral surgery (p = 0.009). Overall, 1,009 (92%) maintained or increased the amount of golf played, 270 (25%) returned to iron shots at six weeks, 842 (76%) returned to club competition at six months, 66 (6%) had persistent pain, and 18 (1.6%) were unable to return to play. Conclusion Hip and knee arthroplasty enables patients to maintain or increase the amount of golf played. The majority return to competitions within one year. Return to iron shots occurs from six weeks. A small increase in handicap following surgery is expected and is larger in patients undergoing bilateral surgery or those with knee arthroplasty to their trailing leg. Patients may still experience pain when playing golf. Cite this article: Bone Jt Open 2022;3(6):510–514.
New-World Spread of the Old-World Robust Crazy Ant, Nylanderia bourbonica (Forel) (Hymenoptera: Formicidae)
Authors: Wetterer James Kelly 
Published: June 2022

The robust crazy ant, Nylanderia bourbonica (Forel) (formerly Paratrechina bourbonica), is native to the Old-World tropics and subtropics. Its earliest known record in the New World was collected in 1924 in Miami, Florida. Here, I examine the subsequent spread of this species to other parts of North America and the West Indies. I compiled published and unpublished New World N. bourbonica specimen records from 446 sites, documenting the earliest known records for 24 geographic areas (countries, island groups, major islands, and US states), including nine for which I found no previously published records: Anguilla, Antigua, Barbuda, British Virgin Islands, Jamaica, Turks and Caicos Islands, Missouri, New York, and Washington. The vast majority of New World site records for N. bourbonica (89%) come from Florida, where this species is now known from 37 counties. Most, if not all, of the 14 site records of N. bourbonica in North American north of 30.5°N come from indoors. Although the earliest record of N. bourbonica from Cuba dates to 1933, the spread of N. bourbonica to many West Indian islands appears to be much more recent. In Florida, N. bourbonica is a widespread, though relatively minor household and agricultural pest, and also is common in some more natural environments. It remains to be seen whether N. bourbonica will become a significant pest in the West Indies or elsewhere in the New World.
Retour sur deux paniques morales canoniques aux États-Unis dans les années 1930 : l’apport d’une perspective interinstitutionnelle
Authors: Philibert Anne 
Published: June 2022

La diabolisation du cannabis et de ses consommateurs dans les années 1930 aux États-Unis est devenue un exemple classique de « panique morale » dans la littérature des sciences sociales. À partir d’un retour sur cet épisode qui s’est particulièrement manifesté à l’intérieur du Federal Bureau of Narcotics, et grâce à la mise en perspective avec un épisode parallèle de campagne de lutte contre le crime menée par le Federal Bureau of Investigation, je suggère deux voies possibles pour discuter de l’apport heuristique de la panique morale dans l’analyse sociologique. D’une part, en s’intéressant au contexte institutionnel de production de la panique morale, on montrera qu’elle illustre la montée de la recherche de l’efficacité dans les deux agences, à travers notamment le développement d’une police scientifique, moderne, et professionnelle. D’autre part, en restituant le contexte politique de ces deux séquences, il sera possible de montrer comment celles-ci révèlent les défis liés à l’expansion des pouvoirs du gouvernement fédéral.
Verdicts médiatiques et contestations juvéniles. Analyse de la dynamique et des effets des « paniques morales » autour des mangas et « japoniaiseries » en France
Authors: Vanhée Olivier 
Published: June 2022

Cet article se propose d’analyser les dynamiques, les effets et les usages des « paniques morales » ayant eu pour objet les mangas et les séries d’animation japonaise en France. Il s’appuie sur l’analyse des entretiens réalisés avec des lecteurs et lectrices nés des années 1960 aux années 1980 (dont une partie sont des professionnels et des intermédiaires culturels dans le domaine du manga – libraires, éditeurs, journalistes, etc.), ainsi que sur l’étude d’un corpus de discours médiatiques (presse professionnelle et fanzines, archives audiovisuelles et numériques). Il procédera en deux temps pour analyser les discours médiatiques, les jugements de valeur et les mobilisations que la réception française des mangas a mis en jeu. Il s’agira d’abord de restituer la temporalité, les supports médiatiques et les registres discursifs de ces prises de position alarmistes, puis d’envisager les propriétés des « entrepreneurs de morale » qui font perdurer ces inquiétudes publiques au cours des années 1980 et 1990, leurs ressources et les effets de leur action dans les arènes médiatique, politique, judiciaire et administrative. Une deuxième partie s’attachera aux « contre-discours » et aux mobilisations de collectifs d’amateurs de manga et de professionnels de l’édition et du journalisme spécialisé, ainsi qu’aux formes de régulation morale qu’ils mettent en œuvre de manière routinisée.
The Relationship of Grain Size to Nickel Grade at Saprolite Zone of Lateritic Nickel Deposite in Moronopo Site, East Halmahera Regency, North Maluku
Authors: Winarno Tri , Ali Rinal Khaidar , Komala Resa 
Published: June 2022

The research was conducted at the Dinding A and Dinding B, Moronopo Site PT Antam Tbk, East Halmahera, North Maluku which is a block that has been opened for the mining process. Generally the stratigraphy of laterite nickel deposits, from top (young) to bottom (old) consists of overburden, limonite, saprolite and bedrock. The saprolite zone is an economical ore layer for Ni content. This research aims to determine the relationship between grain size of ore and the mineralogy and economical Ni content. The research methods used include the grain size fractionation method with sizes of -5 cm, +5 cm, +10 cm, +15 cm, +20 cm and +25 cm, and XRF analysis to determine the Ni content. The result of this study shows the rocks in the saprolite zone containing minerals such as olivine, serpentine, garnierite and chrysoprase. The XRF analysis result shows the highest Ni content is found in the finest grain fraction (-5 cm) i.e. 2.4% and the lowest Ni content found in the coarsest grain fraction (+25 cm) i.e. 1.87 % but is still classified as economic.
Characterization of rabbit polyclonal antibody against camel recombinant nanobodies
Authors: Khalaf Houssam-Eddin , Al-Bouqaee Hassan , Hwijeh Manal , Abbady Abdul Qader 
Published: June 2022

Abstract
Nanobodies (Nbs) are recombinant single-domain fragments derived from camelids’ heavy-chain antibodies (HCAbs). Nanobodies are increasingly used in numerous biotechnological and medical applications because of their high stability, solubility, and yield. However, one major obstacle prohibiting Nb expansion is the affordability of specific detector antibodies for their final revelation. In this work, the production of a specific anti-Nb antibody as a general detector for camel antibodies, conventional cIgG, and HCAb, and their derived Nbs was sought. Thus, a T7 promoter plasmid was constructed and used to highly express six different Nbs that were used in a successful rabbit immunization. Affinity-purified rabbit anti-Nb rIgG was able to detect immobilized or antigen-bound Nbs via enzyme-linked immunosorbent assay, and its performance was comparable to that of a commercial anti-6× His antibody. Its capacities in dosing impure Nbs, detecting Nbs displayed on M13 phages, and revealing denatured Nbs in immune blotting were all proven. As expected, and because of shared epitopes, rabbit anti-Nb cross-reacted with cIgG, HCAbs, and 6× His-tagged proteins, and the percentage of each fraction within anti-Nb rIgG was determined. Anti-Nb is a promising tool for the checkpoints throughout the recombinant Nb technology.
Rhotics, /uː/, and diphthongization in New Braunfels German
Authors: Warmuth Matthias 
Published: June 2022

AbstractThis paper investigates the status of rhotics, /uː/, and the diphthongization of /eː/ and /oː/ in New Braunfels German, a variety of Texas German, a set of moribund dialects spoken in Texas. Boas, Hans C. (2009a.The life and death of Texas German. Durham: Duke University Press: 158) notes that “retroflex /ɻ/ appears … [mainly] in borrowed words.” He further assumes that New Braunfels German “differs from other German American dialects such as Pennsylvania German and Wisconsin German in that English sounds almost never appear in native German words” (160). The results discussed here indicate that this statement no longer holds true. Today, perceptual analysis and phonological measurements of Texas German Dialect Project data reveal that both American English retroflex approximants and diphthongs [eɪ] and [oʊ] appear frequently. Moreover, /uː/ is sometimes centralized/fronted with short/mid-long quality. Language attrition and language death, two mutually reinforcing variables, appear as the driving forces for these phenomena.
Mammalian social memory relies on neuromodulation in the olfactory bulb
Authors: Suyama Hajime , Egger Veronica , Lukas Michael 
Published: June 2022

Abstract
In this review, we aim to integrate our recent findings on the vasopressin system and its role in social discrimination with other known neuromodulatory mechanisms in the olfactory bulb that are involved in different experimental models of social memory. Behavioral paradigms commonly used to investigate odor-related social memory are individual social memory in rodents, lamb recognition in sheep, and the Bruce effect in female mice. All three cases involve neuromodulation in the main and/or the accessory olfactory bulb, the first centers for olfactory processing. As a large diversity of neuromodulators participate in social memory formation, here, we focus primarily on shared neuromodulatory systems and their physiological effects, in particular, the social neuropeptides, vasopressin and oxytocin, and the arousal-related modulators, acetylcholine and noradrenaline.
Nanotherapeutics for hydrogen sulfide-involved treatment: An emerging approach for cancer therapy
Authors: Fan Xiaoyu , Fei Weidong , Zhang Meng , Yang Shan , Zhao Mengdan , Zheng Caihong 
Published: June 2022

Abstract
Hydrogen sulfide (H2S), as the third gasotransmitter, plays important roles in promoting the growth, proliferation, and metastasis of cancer cells. Recently, emerging nanotherapeutics have been developed for cancer therapy by regulating the H2S concentration at tumor sites. The action of H2S in cancer therapy can be demonstrated by a bell-shaped dose-response curve. In addition to the H2S donation from gas therapy, reducing the level of intratumoral H2S can also exert an antitumor effect by disturbing the redox balance of tumor cells. On top of that, the integration of nanotechnology further enhances the diversity of H2S-involved cancer treatments. As a result, phototherapy, chemotherapy, immunotherapy, and ultrasonic therapy can all be realized by designing nanotherapeutics based on the physicochemical properties of H2S. Furthermore, the active/passive targeting effects and onsite H2S-regulating ability of nanotherapeutics greatly improve the safety of treatment. To track the development and promote the clinical transformation of H2S-involved nanotherapeutics, this review introduced the antitumor-related properties of H2S gas and the evolution of H2S-involved cancer therapy. Then, we discussed the design concepts and mechanisms of H2S-involved nanotherapeutics in depth. Finally, the future expectations and challenges were spotlighted in the concept of translational medicine.
What is New in the Neolithic? – Celebrating the Academic Achievements of Lech Czerniak in Honour of His 70th Birthday
Authors: Pyzel Joanna , Michalak Katarzyna Inga , Barański Marek Z. 
Published: June 2022

Abstract
In the Editorial for the Special Issue What is New in the Neolithic? dedicated to Lech Czerniak in honour of his 70th birthday, we outline the articles in this collection.
Preparation, quality control, biological evaluation, and human absorbed dose estimation of 188Re-HYNIC-TOC
Authors: Shokri Sajjad , Johari-Daha Fariba , Aghamiri Seyed Mahmoud Reza , Karamivand Meysam , Zolghadri Samaneh , Yousefnia Hassan 
Published: June 2022

Abstract
In this study, concerning the advantages of rhenium-188 over other therapeutic radionuclides, such as its stock availability from 188W/188Re generator and radiolabeled peptide therapy in the treatment of patients with widespread disease, preparation and quality control of 188Re-HYNIC-TOC were studied. Optimized conditions for radiolabeling of HYNIC-TOC with 188Re were assessed by several experiments. 188Re-HYNIC-TOC was prepared with radiochemical purity >97%. The radiolabelled compound showed high stability both in PBS buffer and in human serum even after 24 h. Biodistribution of the complex in male Wistar rats was examined up to 24 h after intravenous injection and indicated fast blood clearance and significant accumulation in the kidney. The radiation absorbed dose assessment resource (RADAR) method was used to estimate the equivalent and effective absorbed dose of human organs. Kidney received the absorbed dose of 0.72 mSv/MBq, the highest estimated amount, after injection of the complex. The results showed fast preparation, easy quality control, and relatively similar biodistribution of 188Re-HYNIC-TOC to other peptides. This complex can be considered as an agent for the treatment of patients with medium-sized tumors expressing somatostatin receptors. However, more biological studies are still needed.
THE ROLE OF QUALITY CONTROL ON THE FORMATION OF AUDITOR’S PROFESSIONAL SKEPTICISM
Authors: Utaminingsih Nanik Sri , Januarti Indira , Ary Helmina Monica Rahardian 
Published: June 2022

AbstractPurpose: This study aimed to determine the ability of quality control to moderate the relationship between time pressure, locus of control, and professional skepticism of auditors. Method: The population included auditors in the city of Semarang, Indonesia. Data were collected using questionnaires distributed to 100 respondents with only 78 returned while the hypotheses were tested through the use of multiple regression methods.Findings: The results showed two hypotheses, the first and third, were not accepted. This, therefore, means time pressure does not affect professional skepticism and there was no moderating effect of quality control on this relationship. The remaining two hypotheses, second and fourth, were accepted. This indicates there was an influence of external locus of control on professional skepticism and quality control was able to moderate this effect.Novelty: The research’s originality was the use of Professional Skepticism variable which is made up of ethical dilemmas, knowledge and experience gap, deadline pressure, auditor characteristic, and feedback. However, several situational factors like the quality control are usually adopted in a public accounting firm as a moderating variable to improve the direct effect of certain determinants on professional skepticism Keywords: Professional skepticism, Time pressure, Locus of Control, Quality Control
Intensitas Paparan Debu Zinc Oksida pada Tempat Latihan Terhadap Performa Atlet Angkat Besi Jawa Tengah
Authors: Andani Lina Farda 
Published: June 2022

Aktivitas olahraga saat ini menjadi salah satu kegiatan yang marak disemua kalangan masyarakatÂ dimulai dengan lari pagi sampai dengan kebutuhan prestasi. Salah satunya dengan berlatih angkat beban yang sering disebut dengan fitness. Untuk menunjang keberhasilah seorang atlet diperlukan tempat latihan yang bersih dari debu. Adanya debu di tempat latihan maupun perlombaan perlu diperhatikan. Salah satunya tempat latihan atlet angkat besi. Dalam latihan dan perlombaan angkat besi dibutuhkan bubuk magnesium yaitu Zinc Oksida untuk penghilang licin pada saat mengangkat beban. Penggunaan Zinc Oksida terus menerus pada saat latihan mengakibatkan penurunan terhadap performa atlet dan kualitas fisiologi paru-paru atlet. Gangguan fisiologis paru dianalisis dari nilai Forced Volume Capacity (FVC) menggunakan spirometer digital dengan standar ETS / ARS. Tingkat debu yang dihasilkan oleh studi sebesar Â 17.921 mg / m3 melebihi ambang batas. Dari pengukuran fisiologis paru, menghasilkan 33,33% atlet yang menderita gangguan pernapasan restriksi ringan dan penurunan fisiologi yang menyebabkan penurunan performa atlet disebabkan oleh penggunaan Zinc Oksida di tempat latihan.Â
Extraction and quantification of melatonin in cornelian cherry (Cornus mas L.) by ultra-fast liquid chromatography coupled to fluorescence detector (UFLC-FD)
Authors: Uğur Yılmaz 
Published: June 2022

AbstractWild edible plants (WEPs) can be widely found in the world and defined as native species that grow naturally in their natural habitat. They have become part of the traditional food as human diet and used in folk medicine to treat diseases. They are very rich in terms of nutraceuticals. Melatonin is a natural hormone providing several benefits for human health. It has functions such as regulating growth and development and increasing tolerance to environmental stress factors in plants. It is stated that the serum melatonin level in humans increases after intake of foods containing melatonin. This study examined the presence of melatonin in wild grown cornelian cherry fruits by UFLC-FD and determined suitable extraction and chromatographic conditions. The optimum mobile phase, excitation/emission wavelength, and extraction solvent were determined as methanol: water: acetic acid, 275/345 nm, and methanol: water: HCl, respectively. Melatonin content in fruits ranged from 130.82 to 201.84 ng g−1 in fresh fruit.