bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incarceration: An Unrecognized Public Health Crisis
Authors: DuWors Robert , Lang Peter , Derry James , Hoffman Peter , Wolford Robert , Donovan-Dorval Christopher , Capece Jesse 
Published: April 2022

AbstractBackgroundThe current study involved decades of research and a Systematic Literature Review.MethodsSix hundred and seventy-two former prisoners were interviewed, shortly upon release from incarceration. Multiple variables experienced while incarcerated were reviewed. Animal models around overcrowding and sustained levels of stress were also considered. The neurological underpinnings and relatedness to the concept of hypervigilance, thought to be an effective survival technique and PTSD were comprehensively researched. Hypervigilance is a well-regarded survival technique that is likened to the marine in a forward foxhole who hears a twig snap in the middle of the night and responds directly and decisively. The loading placed on the neuronal pathways and related brain regions is seen as a precursor to PTSD and otherwise burdensome to the overstimulated nervous system attempting to maintain an emotional equilibrium.ResultsA particular area of inquiry was around the presence of early parental/adult absence, recognized as a precursor to Complex PTSD (see World Health Organization ICD 11). But not delineated in DSM 5 (American Psychiatric Association). Significant rates of PTSD symptoms were identified in individuals experiencing early developmental trauma. All subjects met the criteria for Subthreshold PTSD at a minimum, and others (193) Posttraumatic Stress Disorder. Complex PTSD was descriptive of the findings of 179 of 193 subjects diagnosed with PTSD. These findings suggest that preexisting subthreshold Complex PTSD prior to incarceration predicts the development of Complex PTSD while incarcerated.ConclusionThe social cost of American Corrections incubates PTSD and subthreshold PTSD, releasing to society individuals more at risk to themselves and society than prior to the Correctional experience is incalculable. A philosophical reconsideration of the American Correctional experience at this time is long overdue. This philosophy is grounded on the concepts of Incapacitation; Punishment and Deterrence, v the European model generally of Rehabilitation and Reintegration.FundingNo funding
Relationships between maternal body mass index and child cognitive outcomes at 3 years of age are buffered by specific early environments in a prospective Canadian birth cohort
Authors: West Zoe , Demchenko Iryna , Clark Lee , White Marina , MacFarlane Amanda J. , Fraser William D. , Arbuckle Tye E. , Connor Kristin L. ,   the MIREC Study Group
Published: April 2022

AbstractFetal and child development are shaped by early life exposures, including maternal health states, nutrition and educational and home environments. We aimed to determine if suboptimal pre-pregnancy maternal body mass index (BMI; underweight, overweight, obese) would associate with poorer cognitive outcomes in children, and whether early life nutritional, educational and home environments modify these relationships. Self-reported data were obtained from mother-infant dyads from the pan-Canadian prospective Maternal-Infant Research on Environmental Chemicals cohort. Relationships between potential risk factors (pre-pregnancy maternal BMI, breastfeeding practices and Home Observation Measurement of the Environment [HOME] score) and child cognitive development at age three (Weschler’s Preschool and Primary Scale of Intelligence, Third Edition scale and its subcategories) were each evaluated using analysis of variance, multivariable regression models and moderating analyses. Amongst the 528 mother−child dyads, increasing maternal pre-pregnancy BMI was negatively associated with scores for child full-scale IQ (β [95% CI]; −2.01 [−3.43, −0.59],p= 0.006), verbal composite (−1.93 [−3.33, −0.53],p= 0.007), and information scale (−0.41 [−0.70, −0.14],p= 0.003) scores. Higher maternal education level or HOME score attenuated the negative association between maternal pre-pregnancy BMI and child cognitive outcome by 30%–41% and 7%–22%, respectively, and accounted for approximately 5%–10% greater variation in male children’s cognitive scores compared to females. Maternal education and higher quality home environment buffer the negative effect of elevated maternal pre-pregnancy BMI on child cognitive outcomes. Findings suggest that relationships between maternal, social and environmental factors must be considered to reveal pathways that shape risk for, and resiliency against, suboptimal cognitive outcomes in early life.
Participation of Women in the Annual Lunar and Planetary Science Conferences
Authors: Zellner N. E. B. , Rathbun J. A. , Martindale N. L. , Seidel A. M. 
Published: April 2022

AbstractIn recent years, conversations about the low representation of marginalized groups in most science, technology, engineering, and mathematics fields are occurring more frequently. Multiple studies reported that members of these groups are underrepresented as conference attendees, as members of conference organizing committees, and as speakers at conferences, where presenting research is important for career advancement. Planetary science has benefited from two workforce studies, and as the number of women in planetary science is increasing, their conference participation should, too. Through analyses of conference abstract author data, and to interpret the data from the workforce studies in the context of meeting participation, we studied the representation of scientists perceived to be women at the annual Lunar and Planetary Science Conference between 1999 and 2017. In the most recent five years, we find that the percentages of attendees with talks were nearly identical for men and women, and that, in general, women were represented as speakers in proportion to their numbers in the field of planetary science. This is in contrast to other professional conferences that draw from the same population of scientists and may be the result of the way the conference program is organized by a centralized committee rather than by separate session conveners. While representation of people perceived to be women has improved, we have limited data on members of other marginalized groups, including nonbinary scientists and scientists of color. In order to enable an understanding of challenges and barriers to success for members of all groups, especially those who identify along multiple axes, conferences should solicit self‐identified gender, race, career stage, and other information.
The Transience of Channel‐Spanning Logjams in Mountain Streams
Authors: Wohl Ellen , Iskin Emily P. 
Published: April 2022

AbstractWe use 11 years of annual surveys in streams of the Southern Rockies of Colorado, USA, to examine the persistence and geomorphic effects of logjams. Each year’s survey includes ∼300 logjams along more than 21 km of four mountain streams in primarily old‐growth subalpine forest. Streams alternate longitudinally between laterally confined reaches with a single channel and wider reaches with multithread‐channel planform. We distinguish logjam persistence and site persistence. Logjam persistence is the median timespan over which an individual jam is present. Site persistence describes the tendency for jams to disappear and then re‐form at the same site. We hypothesize that (a) site persistence is greatest in multithread reaches, (b) logjam persistence is greatest in multithread reaches, and (c) average backwater storage at each jam is greater in multithread reaches. We find that spatial and temporal metrics of site persistence differ significantly between single and multithread reaches. Individual logjam persistence does not differ significantly. Backwater storage is significantly greater in multithread reaches. Varying combinations of riparian forest age and average logjams per channel length explain variation in jam and site persistence and backwater storage via multivariate linear regression analyses. Over the 11 years of survey, a total of 429 distinct logjams were observed. Only 2.1% of the population was present for all 11 annual surveys. Median jam persistence is 1–2.5 years; median site persistence is 6–10 years. Despite the transience of most channel‐spanning logjams in the population, these jams create persistent effects in channel planform and backwater storage.
Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons
Authors: Wagle Mahendra , Zarei Mahdi , Lovett-Barron Matthew , Poston Kristina Tyler , Xu Jin , Ramey Vince , Pollard Katherine S. , Prober David A. , Schulkin Jay , Deisseroth Karl , Guo Su 
Published: April 2022

AbstractSalient sensory stimuli are perceived by the brain, which guides both the timing and outcome of behaviors in a context-dependent manner. Light is such a stimulus, which is used in treating mood disorders often associated with a dysregulated hypothalamic-pituitary-adrenal stress axis. Relationships between the emotional valence of light and the hypothalamus, and how they interact to exert brain-wide impacts remain unclear. Employing larval zebrafish with analogous hypothalamic systems to mammals, we show in free-swimming animals that hypothalamic corticotropin releasing factor (CRFHy) neurons promote dark avoidance, and such role is not shared by other hypothalamic peptidergic neurons. Single-neuron projection analyses uncover processes extended by individual CRFHy neurons to multiple targets including sensorimotor and decision-making areas. In vivo calcium imaging uncovers a complex and heterogeneous response of individual CRFHy neurons to the light or dark stimulus, with a reduced overall sum of CRF neuronal activity in the presence of light. Brain-wide calcium imaging under alternating light/dark stimuli further identifies distinct and distributed photic response neuronal types. CRFHy neuronal ablation increases an overall representation of light in the brain and broadly enhances the functional connectivity associated with an exploratory brain state. These findings delineate brain-wide photic perception, uncover a previously unknown role of CRFHy neurons in regulating the perception and emotional valence of light, and suggest that light therapy may alleviate mood disorders through reducing an overall sum of CRF neuronal activity.
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy
Authors: Belaidi Abdel Ali , Masaldan Shashank , Southon Adam , Kalinowski Pawel , Acevedo Karla , Appukuttan Ambili T. , Portbury Stuart , Lei Peng , Agarwal Puja , Leurgans Sue E. , Schneider Julie , Conrad Marcus , Bush Ashley I. , Ayton Scott 
Published: April 2022

AbstractAllelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC50 ≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical Alzheimer’s disease was stronger among those with the adverse APOE-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele’s heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD.
Global population attributable fraction of potentially modifiable risk factors for mental disorders: a meta-umbrella systematic review
Authors: Dragioti Elena , Radua Joaquim , Solmi Marco , Arango Celso , Oliver Dominic , Cortese Samuele , Jones Peter B. , Il Shin Jae , Correll Christoph U. , Fusar-Poli Paolo 
Published: April 2022

AbstractNumerous risk factors for mental disorders have been identified. However, we do not know how many disorders we could prevent and to what extent by modifying these risk factors. This study quantifies the Population Attributable Fraction (PAF) of potentially modifiable risk factors for mental disorders. We conducted a PRISMA 2020-compliant (Protocol: https://osf.io/hk2ag) meta-umbrella systematic review (Web of Science/PubMed/Cochrane Central Register of Reviews/Ovid/PsycINFO, until 05/12/2021) of umbrella reviews reporting associations between potentially modifiable risk factors and ICD/DSM mental disorders, restricted to highly convincing (class I) and convincing (class II) evidence from prospective cohorts. The primary outcome was the global meta-analytical PAF, complemented by sensitivity analyses across different settings, the meta-analytical Generalised Impact Fraction (GIF), and study quality assessment (AMSTAR). Seven umbrella reviews (including 295 meta-analyses and 547 associations) identified 28 class I–II risk associations (23 risk factors; AMSTAR: 45.0% high-, 35.0% medium-, 20.0% low quality). The largest global PAFs not confounded by indication were 37.84% (95% CI = 26.77–48.40%) for childhood adversities and schizophrenia spectrum disorders, 24.76% (95% CI = 13.98–36.49%) for tobacco smoking and opioid use disorders, 17.88% (95% CI = not available) for job strain and depression, 14.60% (95% CI = 9.46–20.52%) for insufficient physical activity and Alzheimer’s disease, 13.40% (95% CI = 7.75–20.15%) for childhood sexual abuse and depressive disorders, 12.37% (95% CI = 5.37–25.34%) for clinical high-risk state for psychosis and any non-organic psychotic disorders, 10.00% (95% CI = 5.62–15.95%) for three metabolic factors and depression, 9.73% (95% CI = 4.50–17.30%) for cannabis use and schizophrenia spectrum disorders, and 9.30% (95% CI = 7.36–11.38%) for maternal pre-pregnancy obesity and ADHD. The GIFs confirmed the preventive capacity for these factors. Addressing several potentially modifiable risk factors, particularly childhood adversities, can reduce the global population-level incidence of mental disorders.
Returning individual research results in international direct-to-participant genomic research: results from a 31-country study
Authors: Lang Michael , Zawati Ma’n H. 
Published: April 2022

AbstractThis paper summarizes the results of a 31-country qualitative study of expert perspectives on the regulation of international “direct-to-participant” (DTP) genomic research. We outline how the practice of directly recruiting participants for genomic studies online complicates ethics and regulatory considerations for the return of individual research results. As part of a larger project supported by the National Human Genome Research Institute, National Institutes of Health, we prepared and distributed to 31 global legal experts a questionnaire intended to ascertain opinions and perspectives on the way international DTP genomic research is likely to be regulated. We found significant disagreement across jurisdictions on the most favorable approach to managing such results, with some countries favoring return by default and others preferring to return only with the express consent of research participants. We conclude by outlining policy considerations that should guide researcher practices in this context. As international DTP genomic research evolves, jurists and ethicists should be attentive to the ways novel approaches to subject recruitment align with existing ethical and regulatory norms in research with human participants. This paper is a preliminary step toward documenting such alignment in the context of the return of individual research results.
A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)
Authors: Amiel Stephanie A. , Potts Laura , Goldsmith Kimberley , Jacob Peter , Smith Emma L. , Gonder-Frederick Linda , Heller Simon , Toschi Elena , Brooks Augustin , Kariyawasam Dulmini , Choudhary Pratik , Stadler Marietta , Rogers Helen , Kendall Mike , Sevdalis Nick , Bakolis Ioannis , de Zoysa Nicole 
Published: April 2022

AbstractImpaired awareness of hypoglycaemia (IAH) is a major risk for severe hypoglycaemia in insulin treatment of type 1 diabetes (T1D). To explore the hypothesis that unhelpful health beliefs create barriers to regaining awareness, we conducted a multi-centre, randomised, parallel, two-arm trial (ClinicalTrials.gov NCT02940873) in adults with T1D and treatment-resistant IAH and severe hypoglycaemia, with blinded analysis of 12-month recall of severe hypoglycaemia at 12 and/or 24 months the primary outcome. Secondary outcomes included cognitive and emotional measures. Adults with T1D, IAH and severe hypoglycaemia despite structured education in insulin adjustment, +/− diabetes technologies, were randomised to the “Hypoglycaemia Awareness Restoration Programme despite optimised self-care” (HARPdoc, n = 49), a psychoeducation programme uniquely focussing on changing cognitive barriers to avoiding hypoglycaemia, or the evidence-based “Blood Glucose Awareness Training” (BGAT, n = 50), both delivered over six weeks. Median [IQR] severe hypoglycaemia at baseline was 5[2–12] per patient/year, 1[0–5] at 12 months and 0[0–2] at 24 months, with no superiority for HARPdoc (HARPdoc vs BGAT incident rate ratios [95% CI] 1.25[0.51, 3.09], p = 0.62 and 1.26[0.48, 3.35], p = 0.64 respectively), nor for changes in hypoglycaemia awareness scores or fear. Compared to BGAT, HARPdoc significantly reduced endorsement of unhelpful cognitions (Estimated Mean Difference for Attitudes to Awareness scores at 24 months, −2.07 [−3.37,−0.560], p = 0.01) and reduced scores for diabetes distress (−6.70[−12.50,−0.89], p = 0.02); depression (−1.86[−3.30, −0.43], p = 0.01) and anxiety (−1.89[−3.32, −0.47], p = 0.01). Despite positive impact on cognitive barriers around hypoglycaemia avoidance and on diabetes-related and general emotional distress scores, HARPdoc was not more effective than BGAT at reducing severe hypoglycaemia.
Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression
Authors: Paulson Thomas G. , Galipeau Patricia C. , Oman Kenji M. , Sanchez Carissa A. , Kuhner Mary K. , Smith Lucian P. , Hadi Kevin , Shah Minita , Arora Kanika , Shelton Jennifer , Johnson Molly , Corvelo Andre , Maley Carlo C. , Yao Xiaotong , Sanghvi Rashesh , Venturini Elisa , Emde Anne-Katrin , Hubert Benjamin , Imielinski Marcin , Robine Nicolas , Reid Brian J. , Li Xiaohong 
Published: April 2022

AbstractWhile the genomes of normal tissues undergo dynamic changes over time, little is understood about the temporal-spatial dynamics of genomes in premalignant tissues that progress to cancer compared to those that remain cancer-free. Here we use whole genome sequencing to contrast genomic alterations in 427 longitudinal samples from 40 patients with stable Barrett’s esophagus compared to 40 Barrett’s patients who progressed to esophageal adenocarcinoma (ESAD). We show the same somatic mutational processes are active in Barrett’s tissue regardless of outcome, with high levels of mutation, ESAD gene and focal chromosomal alterations, and similar mutational signatures. The critical distinction between stable Barrett’s versus those who progress to cancer is acquisition and expansion ofTP53−/− cell populations having complex structural variants and high-level amplifications, which are detectable up to six years prior to a cancer diagnosis. These findings reveal the timing of common somatic genome dynamics in stable Barrett’s esophagus and define key genomic features specific to progression to esophageal adenocarcinoma, both of which are critical for cancer prevention and early detection strategies.
A strength inversion origin for non-volcanic tremor
Authors: Vannucchi Paola , Clarke Alexander , de Montserrat Albert , Ougier-Simonin Audrey , Aldega Luca , Morgan Jason P. 
Published: April 2022

AbstractNon-volcanic tremor is a particularly enigmatic form of seismic activity. In its most studied subduction zone setting, tremor typically occurs within the plate interface at or near the shallow and deep edges of the interseismically locked zone. Detailed seismic observations have shown that tremor is composed of repeating small low-frequency earthquakes, often accompanied by very-low-frequency earthquakes, all involving shear failure and slip. However, low-frequency earthquakes and very-low-frequency earthquakes within each cluster show nearly constant source durations for all observed magnitudes, which implies characteristic tremor sub-event sources of near-constant size. Here we integrate geological observations and geomechanical lab measurements on heterogeneous rock assemblages representative of the shallow tremor region offshore the Middle America Trench with numerical simulations to demonstrate that these tremor events are consistent with the seismic failure of relatively weaker blocks within a stronger matrix. In these subducting rocks, hydrothermalism has led to a strength-inversion from a weak matrix with relatively stronger blocks to a stronger matrix with embedded relatively weaker blocks. Tremor naturally occurs as the now-weaker blocks fail seismically while their surrounding matrix has not yet reached a state of general seismic failure.
An efficient approach to angular tricyclic molecular architecture via Nazarov-like cyclization and double ring-expansion cascade
Authors: Wang Yun-Peng , Fang Kun , Tu Yong-Qiang , Yin Jun-Jie , Zhao Qi , Ke Tian 
Published: April 2022

AbstractA modular and efficient method for constructing angular tri-carbocyclic architectures containing quaternary carbon center(s) from 1,3-dicycloalkylidenyl ketones is established, which involves an unconventional synergistic cascade of a Nazarov cyclization and two ring expansions. It features high selectivity, mild conditions and convenient operation, wide scope and easy availability of substrate. Substitution with R1 and R2 at the 4πe-system with electron-donating group favors this reaction, while that with electron-withdrawing group or proton disfavors. The electron-donating group as R1 directs the initial ring expansion at its own site, while the p-π- or n-π- associated substituent as R2 favors selectively the later ring expansion near its location because of the beneficial maintenance of an original conjugated system. The stereoselectivity has proved to be governed by either the steric effect of R3 and R4 at the expanded rings, or the migration ability of the migrating atom. Density Functional Theory calculation suggests the initial Nazarov cyclization would be the rate-determining step. A racemic total synthesis of the natural (±)-waihoensene is realized in 18 steps by use of this methodology.