bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the effectiveness of green technological progress and financial innovation on green economic growth: the role of environmental regulation
Authors: Su Ying , Gao Xinwei 
Published: May 2022

Abstract
Green economic growth is the best alternative strategy for sustainable development. Existing literature investigated the determinants of green economic growth in China and provides mixed results. Thus, our study explores the impact of green environmental technology, financial innovation, and environmental regulations on green economic growth by controlling the impact of renewable energy consumption, trade, and education. The study explores the symmetric and asymmetric associations by employing ARDL and NARDL approaches. The ARDL long-run findings display that green environmental technologies, environmental regulations, and financial innovations positively and significantly contribute to green economic growth. However, the NARDL long-run findings infer that positive shock in green environmental technology, financial innovation, and environmental regulation exerts a significant and positive impact on green growth, while negative shock in green environmental technology, financial innovation, and environmental regulation have an insignificant impact on green growth. Based on the findings, the study delivers important policy implications to promote green economic growth in China.
A New Approach to Modelling Pre-symptomatic Incidence and Transmission Time of SARS-CoV-2 Variants
Authors: Chen Sam Li-Sheng , Jen Grace Hsiao-Hsuan , Hsu Chen-Yang , Yen Amy Ming-Fang , Lai Chao-Chih , Yeh Yen-Po , Chen Hsiu-Hsi 
Published: May 2022

Abstract
We applied a four-state stochastic process to decipher the natural infectious process of SARS-CoV-2 superimposed with the disease axis of pre-symptomatic, asymptomatic, and symptomatic states. So doing provides new insights into how pre-symptomatic transmission and the proportion of asymptomatic cases have been affected by SARS-CoV-2 variants, NPIs, and vaccination. We fitted the proposed model to empirical data on imported COVID-19 cases from D614G to Omicron between March 2020 and Jan 2022 in Taiwan. The pre-symptomatic incidence rate was the highest for Omicron followed by Alpha, Delta, and D614G. The median pre-symptomatic transmission time (MPTT) (in days) increased from 3.45 (first period) ~ 4.02(second period) of D614G until 3.94 ~ 4.65 of VOC Alpha before vaccination but dropped to 3.93 ~ 3.49 of Delta and 2 days (only first period) of Omicron after vaccination. The MPTT of the second re-surge was longer than the first surge for each variant before vaccination but this phenomenon disappeared for Delta after vaccination. The proportion of asymptomatic cases increased from 29% of D-614G period to 59.2% of Omicron. Modelling pre-symptomatic incidence and transmission time evolving with SARS-CoV-2 variants throws light on the underlying natural infectious properties of variants and also reveals how their properties are affected by vaccination and NPIs.
New 4D Discrete Hyperchaotic Map and Its Application in Image Encryption
Authors: Wang Xingyuan , Zhou Shuang , Zhang Hongling , Zhang Yingqian 
Published: May 2022

Abstract
In view of low dimensional discrete chaotic systems' weak resistance to degradation, we put forward a new 4D discrete hyperchaotic map, which has larger Lyapunov exponents, wider chaotic range, better distribution and more complexity than the hyperchaotic Lorenz system. In addition, the chaotic signals generated by the proposed map pass the NIST test and are implemented on the hardware DSP. Finally, we combine our chaotic map and dynamic expand XOR (eXOR) and XOR operation in image encryption. The experimental results express that compared with some other methods, the presented encryption algorithm has higher security and can resist common attacks.
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes
Authors: Saha Liton , Saha Sourav , Yang Xi , Huang Shar-yin , Sun Yilun , Pommier Yves 
Published: May 2022

Abstract
Topoisomerase IIIα (TOP3A) belongs to the conserved Type IA family of DNA topoisomerases. Here we report that TOP3A is associated with DNA replication as well as a TOP3A "self-trapping" mutant (TOP3A- R364W) that generates TOP3A DNA cleavage complexes (TOP3Accs) in human cells. We show that trapped TOP3Accs interfere with replication, induce DNA damage and genome instability. To elucidate the repair of TOP3Accs, we explored the role of Spartan (SPRTN), the metalloprotease associated with DNA replication, which digests proteins forming DNA protein crosslinks (DPCs). SPRTN-deficient cells show elevated TOP3Accs, whereas overexpression of SPRTN lowers cellular TOP3Accs. SPRTN is deubiquitinated and epistatic with TDP2 in response to TOP3Accs. In addition, we found that MRE11 can excise TOP3Accs and that cell cycle phases determine the preference for the SPRTN-TDP2 vs. the ATM- MRE11 pathways, in S vs. G2, respectively. Our study highlights the prevalence of TOP3Accs repair mechanisms to ensure normal DNA replication.
Reactive Molecular Dynamics Study on the Thermal Decomposition Reaction of a Triple-base Solid Propellant
Authors: Yi Jianhua , Qin Zhao , Li Haijian , Zhao Fengqi , Ma Haixia , Guo Zhaoqi 
Published: May 2022

Abstract
The study of the combustion property of newly designed propellant by means of computational simulation is an efficient pathway for assessment and could avoid exposure to hazardous chemicals. An RDX modified triple-base solid propellant formula was proposed in this study. Reactive molecular dynamics simulations employing ReaxFF-lg force field were performed to explore the thermal decomposition property of the propellant for a variety of temperatures. The reaction kinetics of the system and major ingredients were analyzed and the apparent decomposition activation energies were calculated. The population of decomposition intermediates and products is thoroughly investigated. H2O is consumed at high temperatures indicating a water-gas reaction that could reduce carbon clusters during the combustion of solid propellant. The water-gas reaction, as well as the population of H2 at high temperature, point out the way of adjusting the formula of the propellant, that is adds fuel and oxidizer to improve combustion temperature and oxygen balance.
Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients
Authors: You Ji Young , Park Kyoung Hwa , Lee Eun Sook , Kwon Youngmee , Kim Kyoung Tae , Nam Seungyoon , Kim Dong Hee , Bae Jeoung Won 
Published: May 2022

Abstract
Purpose: We aimed to identify the overexpressed genes or related pathways associated with good responses to anti-HER2 therapy and to suggest a model for predicting drug response in neoadjuvant systemic therapy with trastuzumab in HER2-positive breast cancer patients.Methods: We recruited 64 women with breast cancer and categorized them into 3 groups: complete response (CR), partial response (PR), and drug resistance (DR). The final number of patients in the study was 20. RNA from 20 core needle biopsy paraffin-embedded tissues and 4 cultured cell lines (SKBR3 and BT474 breast cancer parent cells and cultured resistant cells) was extracted, reverse transcribed, and subjected to GeneChip array analysis. The obtained data were analyzed using Gene Ontology, Kyoto Gene and Genome Encyclopedia, Database for Annotation, Visualization and Integrated Discovery. Results: In total, 6,656 genes differentially expressed between trastuzumab-susceptible and trastuzumab-resistant cell lines were identified. Among these, 3,224 were upregulated and 3,432 were downregulated. Expression changes in 34 genes in several pathways were found to be related to the response to trastuzumab-containing treatment in HER2-type breast cancer, interfering with adhesion to other cells or tissues (focal adhesion) and regulating extracellular matrix interactions and phagosome action. Thus, decreased tumor invasiveness and enhanced drug effects might be the mechanisms explaining the better drug response in the CR group.Conclusions: This multigene assay-based study provides insights into breast cancer signaling and possible predictions of therapeutic response to targeted therapies such as trastuzumab.
Latent Profile Analysis for Quality of Life in Older Patients
Authors: Băjenaru Lidia , Balog Alexandru , Dobre Ciprian , Drăghici Rozeta , Prada Gabriel-Ioan 
Published: May 2022

Abstract
Background: Quality of life (QOL) is a complex concept known for being influenced by socio-demographic characteristics, individual needs, perceptions and expectations. The study investigates influences of such heterogeneous variables and aims to identify and describe subgroups of older patients who share similar response patterns for the four domains (physical health, psychological health, social relationships and environment) of World Health Organization Quality of Life instrument, Short Form (WHOQOL-BREF).Methods: The sample used included older Romanian patients (N = 60; equal numbers of men and women; mean age was 71.95, SD=5.98). Latent Profile Analysis (LPA) was conducted to explore quality of life profiles with the four WHOQOL-BREF domains as input variables. Differences between profiles were analysed by MANOVA and ANOVAs as a follow-up. Results: The LPA results showed that the three-profile model was the most suitable and supported the existence of three distinct QOL profiles: low and very low (28.3%), moderate (63.3%) and high (8.4%). The relative entropy value was high (.86), results pointed to a good profile solution and the three profiles differed significantly from one another.Conclusions: Our results reveal heterogeneity within the older adult sample and provide meaningful information to better tailor QOL improvement programs to the needs of older patient groups, especially those designed for patients of profiles related to poorer QOL in different domains.
A spontaneous pulmonary fibrosis mouse model identifies a mechanism for ILC2-mediated irreversible fibrosis
Authors: Moro Kazuyo , Otaki Natsuko , Motomura Yasutaka , Terooatea Tommy , Kelly S. Thomas , Mochizuki Miho , Takeno Natsuki , Koyasu Shigeo , Sugihara Fuminori , Kikuta Junichi , Kitamura Hideya , Shiraishi Yoshiki , Miyanohara Jun , Nagano Yuji , Saita Yuji , Ogura Takashi , Asano Koichiro , Minoda Aki 
Published: May 2022

Abstract
Pulmonary fibrosis (PF) is characterised by inflammation and collagen deposition in the alveolar interstitium, leading to dyspnoea and death. However, the comprehensive pathogenesis of PF remains unclear due to the lack of spontaneous fibrosis mouse models. Here, we found that Ifngr1-/-Rag2-/- mice, lacking the mechanisms to suppress group 2 and 3 innate lymphoid cells (ILC2s and ILC3s), developed severe PF spontaneously. In Ifngr1-/-Rag2-/- mice, Il1rl1hiIl13hi-ILC2 subpopulation was increased at disease-onset phase before collagen production began. Further, defects in ILCs or IL-33, the strong ILC2 activator, prevented PF development. ILC2s directly induce collagen production by fibroblasts in vitro, and fibroblasts started to produce IL-33 in the chronic phase, presumably forming a positive feedback loop between fibroblasts and ILC2s leading to irreversible fibrosis. Moreover, the increased IL1RL1 and IL13 and decreased IFNGR1 expression levels in ILC2s from human idiopathic PF patients highlight the significance of the novel mouse model in fibrosis research.
In-vitro Acaricidal Efficacy of Aqueous Extract of Azadirachta Indica and Melia Azedarach Leaves Against Cattle Tick Haylomma Anatolicum
Authors: Hatzade Hatzade R. I. Ravindrakumar , Waghmare Waghmare S. P. Sunil , Kolte Kolte S. W. Sunil , Bhikane Bhikane A. U. Anil , Kuralkar Kuralkar S. V. Shailendra , Hajare Hajare S. W. Sunil , Ingole Ingole R. S. Ranjit 
Published: May 2022

Abstract
The efficacy of a crude aqueous extract of Azadirachta indica and Melia azedarach leaves was evaluated separately and in combination (1:1) for its acaricidal potential against distilled water and Amitraz (12.5% w/v) using cattle tick Haylomma anatolicum. The percent corrected adult tick mortality within 15 days, reproductive index, percentage inhibition of oviposition, hatching percentage of laid eggs, percent hatching rate reduction, and percentage of larval mortality were studied at concentrations of 20, 25, 30, 40, 50, 60, 70 and 100% (v/v). At the concentration of 70% and 100%, the corrected adult tick mortality was 36.67% for A. indica and 33.33% for M. azedarach and combination. Corrected mortality caused by A. indica and M. azedarach extracts separately and in combination was statistically significant (P < 0.001) when compared with the mortality caused by distilled water. Inhibition of oviposition at the 70% and 100% concentration of A. indica, M. azedarach, and combination of leaves extract-treated ticks were 26.28% and 26.65%; 23.86% and 23.89%; 42.34% and 41.48% respectively. Inhibition of oviposition of treated groups was concentration-dependent and highest at 70% and 100% and differed significantly from the control with higher efficacy for a combination of extracts than individually. Larvae treated with all the tested concentrations of A. indica, M. azedarach, and a combination of extracts by larval packet test showed significant mortality (P < 0.001) than that of control and found 70.17% and 70.83% for A. indica, 66.33% and 66.50% for M. azedarach, 63% and 64.33% for a combination of extracts at the 70% and 100% respectively. Complete failure of hatching of eggs from the ticks treated with Amitraz was reported, whereas in A. indica, M. azedarach and combination of extracts hatchability were 56.69%, 56.57%, 49.33% and 54.61%, 56.15%, 47.04% at 70% and 100% respectively. However, hatchability reduction rate were 40.34%, 40.47%, 48.09% and 42.53%, 40.91%, 50.50% for A. indica, M. azedarach and combination at 70% and 100% respectively and 0%, 95.62%, 99.28% for distilled water, Amitraz 2ml/L and 4ml/L respectively. The results pointed out that the crude aqueous extracts of A. indica, M. azedarach, and the combination can be used as an alternative for control of H. anatolicum with good acaricidal potentials.
High-resolution neutron imaging of carbonate precipitation and water transport in zero-gap CO2 electrolysis
Authors: Disch Joey , Bohn Luca , Koch Susanne , Schulz Michael , Han Yiyong , Tengattini Alessandro , Helfen Lukas , Breitwieser Matthias , Vierrath Severin 
Published: May 2022

Abstract
The electrochemical reduction of CO2 is a pivotal technology for the defossilization of the chemical industry. Although first pilot-scale electrolyzers exist, water management and salt precipitation remain a major hurdle to long-term operation. In this work, we present the first high resolution neutron imaging (6 µm) of a zero-gap CO2 electrolyzer to uncover water distribution and salt precipitation under application-relevant operating conditions (200 mA cm− 2 at 2.8 V with a Faraday efficiency for CO of 99%). Precipitated salts penetrating the cathode gas diffusion layer can be observed, which are believed to block the CO2 gas transport and are therefore the major cause for the commonly observed decay in Faraday efficiency. Neutron imaging further shows higher carbonate accumulation under the cathode channel of the flow field compared to the land. In fact, a higher local reaction rate under the land compared to the channel can be estimated from the gas bubble generation on the opposing anode side.
Clinical characteristics of 683 children and adolescents, aged 0–18 years, newly diagnosed with type 1 diabetes mellitus in Henan Province: A single-center study
Authors: Huang Ai , Chen Qiong , Yang Wei , Cui Yan , Wang Qingzhi , Wei Haiyan 
Published: May 2022

Abstract
Background: Type 1 diabetes mellitus (T1DM) is a common chronic systemic disease that threatens the health of children worldwide. Diabetic ketoacidosis (DKA) is the most common acute complication of diabetes and can lead to death in severe cases. This study aimed to explore the epidemiological features, clinical manifestations, and risk factors for DKA in children and adolescents newly diagnosed with T1DM in the Department of Endocrinology of the Children’s Hospital of Henan Province.Methods: Medical records of 683 children and adolescents newly diagnosed with T1DM in our center from March 2014 to November 2021 were retrospectively analyzed. The data included the general condition, laboratory indexes, and clinical symptoms. The patients were divided into three groups according to age: Group I, 0–3 years; Group II, 4–9 years; and Group III, 10 –18years. Results: The incidence of DKA was 62.96% and was highest in Group I. Group I also had the highest C-peptide, insulin, HbA1c, blood glucose at first diagnosis, and 25 hydroxyvitamin D3 levels; hospitalization lengths and costs; and incidence of clinical symptoms. Logistic regression analysis showed that elevated HbA1c levels, hyperglycemia, and other systemic diseases were independent risk factors for DKA. On the other hand, C-peptide and 25 hydroxyvitamin D were protective factors against DKA.Conclusions: The incidence of DKA among children and adolescents in Henan Province is very high. Moreover, DKA can be easily misdiagnosed. Newly diagnosed infants with T1DM are more likely to present with DKA, suffer more severe metabolic disorders, endure longer hospital stays, and accrue higher medical costs. Vitamin D supplementation can help reduce the incidence of DKA in children with diabetes.
Small-scale field evaluation of transfluthrin-treated eave ribbons and sandals for the control of malaria vectors in rural Tanzania
Authors: Mmbando Arnold S. , Mponzi Winifrida P. , Ngowo Halfan S. , Kifungo Khamis , Kasubiri Robert , Njalambaha Rukiyah M. , Gavana Tegemeo , Eiras Alvaro E. , Batista Elis P. A. , Finda Marceline F. , Sangoro Onyango P. , Okumu Fredros O. 
Published: May 2022

Abstract
Background: Early-evening and outdoor-biting may compromise the efficacy of frontline malaria interventions, notably insecticide treated nets (ITNs). This study investigated the potential of low-cost insecticide-treated eave ribbons and sandals against mosquitoes indoors and outdoors in rural-Tanzanian villages where ITNs are widely used and malaria vectors have resistance to pyrethroids.Methods: Seventy-two (72) households were selected from three villages, (24 households per village), and upon consent recruited into the study. The households were divided into four study arms and assigned either transfluthrin-treated sandals (TS), transfluthrin-treated eave ribbons (TER), a combination of TER and TS or experimental controls. Each study arm had 18 households in total, all of which received new ITNs. Mosquitoes were collected using double net traps (to assess outdoor-biting), CDC-light traps (to assess indoor-biting) and Prokopack® aspirators (to assess indoor-resting). To evaluate the level of protection conferred by these tools, mosquito biting and resting densities were compared between treatment groups and control. Additional experiments were done in experimental huts to assess mortality of wild mosquitoes exposed to the treatments.Results: TERs reduced indoor-biting, indoor-resting and outdoor-biting Anopheles arabiensis by 60%, 73% and 41% respectively, while TS reduced the densities by 18%, 40% and 42% respectively. When used together, TER & TS reduced outdoor-biting An. arabiensis by 57% and indoor-biting by 53%. Protection against Anopheles funestus ranged between 42 - 69% by TER and 57 - 74% by TER & TS combined, but protection against Culex mosquitoes did not exceed 32% even when TER and TS were combined. Mortality of field-collected mosquitoes exposed to TER, TS or both interventions ranged from 56 – 78% for An. arabiensis, 47 – 74% for An. funestus and 58 – 63% for Culex spp.Conclusion: Transfluthrin-treated eave ribbons and sandals or their combination can offer moderate household-level protection against common malaria vectors. Their efficacy is likely to be magnified by the transfluthrin-induced mortality, which was observed despite the prevailing pyrethroid resistance in the study area. Overall, the transfluthrin-treated eave ribbons were more efficacious than the sandals. Further studies are needed to improve the technologies and validate their potential as supplementary interventions against mosquitoes and mosquito-borne diseases.
Risk factors for multidimensional attitudes and behaviors of reproductive health toward pregnancy among early and late adolescents in Tanzania: a cross-sectional study
Authors: Hirose Naoki , Sanmei Chen , Okamoto Mariko , Madeni Frida E , Madeni Nicolaus Elikana , Teshima Ayaka , Ando Yasunobu , Takahama Koji , Yoshikawa Mayu , Kunimoto Yu , Shimpuku Yoko 
Published: May 2022

Abstract
BackgroundAdolescent pregnancy is a serious reproductive health problem in Tanzania. However, the risk factors for multidimensional attitudes and behaviors of reproductive health toward pregnancy in Tanzanian adolescents remain unexplored.MethodsWe collected baseline characteristics and information on attitudes and behaviors of reproductive health from 4161 Tanzanian adolescents in all 54 primary and secondary schools in the Korogwe district. We applied mixed effect multiple regression analyses stratified by sex to find the factors related to reproductive health attitudes and behaviors toward pregnancy.ResultsIn female students, regarding the attitudes of reproductive health, higher age, hope for marriage in the future, a talk with a parent about sex or pregnancy, and a higher hope score were significantly associated with a lower score. For the behaviors of reproductive health, higher age, a talk with a parent about sex or pregnancy, time to talk with a parent about daily life, and a higher hope score were significantly associated with a lower score. In male students, regarding the attitudes of reproductive health, a higher hope score was significantly associated with a lower score. For the behaviors of reproductive health, higher age, time to talk with a parent about daily life, and a higher hope score was significantly associated with a lower score.ConclusionsThe heterogeneous factor-outcomes association between female and male students suggested that sex-specialized interventions may be required to change their risky attitudes or behaviors of reproductive health. Although we cannot conclude as points of intervention, our study suggested that it may be effective to improve parent-adolescents communication about sex or reproductive health and change adolescents’ views of pregnancy or marriage for gaining financial or social status.