bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE POLITICS OF LEVELLING UP: DEVOLUTION, INSTITUTIONS AND PRODUCTIVITY IN ENGLAND
Authors: Westwood Andy , Sensier Marianne , Pike Nicola 
Published: November 2022

AbstractAfter the publication of the Government’s ‘Levelling Up’ White Paper, this paper reviews the role of institutions and governance structures across English regions in tackling spatial inequality and low productivity. It considers the recent history and changing roles of local and regional organisations and the overarching policy frameworks that oversee them as a key element of tackling spatial inequality and low productivity. Specifically, the paper looks at the frequent changes to institutional arrangements supporting economic development and the process of allocating competitive funds to local and regional bodies.
Clinical differences between children and adults with idiopathic and heritable pulmonary arterial hypertension
Authors: Takatsuki Shinichi , Shimokawahara Hiroto , Shimizu Yurika , Kawai Reiko , Matsuura Hiroyuki , Matsubara Hiromi 
Published: November 2022

AbstractBackground:Although previous studies have demonstrated that paediatric pulmonary arterial hypertension remains distinct from that in adults, there are limited studies evaluating a direct comparison between children and adults. The aim of this head-to-head comparison study was to compare the gender, haemodynamic parameters, and prognosis between paediatric and adult pulmonary arterial hypertension.Methods and Results:We retrospectively assessed the clinical differences in 40 childhood-onset (under 20 years old) patients and 40 adult-onset patients with idiopathic and heritable pulmonary arterial hypertension who were followed up at two centres. There was no female predominance among patients with childhood-onset pulmonary arterial hypertension (child female: 42.5%, adult female: 80%). The percent of New York Heart Association functional class IV in adult-onset pulmonary arterial hypertension tended to be higher than those in childhood-onset pulmonary arterial hypertension (22.5 and 10%, respectively), although children had worse haemodynamic parameters at diagnosis (mean pulmonary artery pressure (children versus adults); median 65 mmHg versus 49 mmHg, p < 0.001). There was no significant difference in the event-free survival rate between the two groups (95% vs. 85%) during the follow-up period (median, 96 months; range, 1–120 months).Conclusions:Although paediatric pulmonary arterial hypertension patients had worse haemodynamic parameters at diagnosis than adults, children survived as long as adults with appropriate therapeutic strategies.
Head and neck radiotherapy quality assurance conference for dedicated review of delineated targets and organs at risk: results of a prospective study
Authors: Farris J. C. , Razavian N. B. , Farris M. K. , Ververs J. D. , Frizzell B. A. , Leyrer C. M. , Allen L. F. , Greven K. M. , Hughes R. T. 
Published: November 2022

Abstract

Purpose:
Head and neck (HN) radiotherapy (RT) is complex, involving multiple target and organ at risk (OAR) structures delineated by the radiation oncologist. Site-agnostic peer review after RT plan completion is often inadequate for thorough review of these structures. In-depth review of RT contours is critical to maintain high-quality RT and optimal patient outcomes.

Materials and Methods:
In August 2020, the HN RT Quality Assurance Conference, a weekly teleconference that included at least one radiation oncology HN specialist, was activated at our institution. Targets and OARs were reviewed in detail prior to RT plan creation. A parallel implementation study recorded patient factors and outcomes of these reviews. A major change was any modification to the high-dose planning target volume (PTV) or the prescription dose/fractionation; a minor change was modification to the intermediate-dose PTV, low-dose PTV, or any OAR. We analysed the results of consecutive RT contour review in the first 20 months since its initiation.

Results:
A total of 208 patients treated by 8 providers were reviewed: 86·5% from the primary tertiary care hospital and 13·5% from regional practices. A major change was recommended in 14·4% and implemented in 25 of 30 cases (83·3%). A minor change was recommended in 17·3% and implemented in 32 of 36 cases (88·9%). A survey of participants found that all (n = 11) strongly agreed or agreed that the conference was useful.

Conclusion:
Dedicated review of RT targets/OARs with a HN subspecialist is associated with substantial rates of suggested and implemented modifications to the contours.
‘The world is not organized for Peace’: Feminist manifestos and utopias in the making of international law
Authors: Labenski Sheri 
Published: November 2022

AbstractFeminists have utilized manifestos and utopias in order to make important, often revolutionary, contributions to international law. However, these engagements have not been reflected in the substance of international law. The sources of international law – specifically customary international law – rely on a narrow understanding of historical knowledge. This article centres the 1924 manifesto and the ‘New International Order’ created by the Women’s International League for Peace and Freedom, as tools to assess the exclusion of the under-utilized history of feminist peace work from the sources of international law. This allows for a reflection on customary international law’s weaknesses and reaffirms the importance of feminist approaches to international law.
Antecedents and Effects of Online Third-Party Information on Offline	Impressions
Authors: Lane Brianna L. , Cionea Ioana A. , Dunbar Norah E. , Carr Caleb T. 
Published: November 2022

Abstract: Warranting theory articulates the process by which individuals connect online information to an offline target, guiding impression formation. The presence of online information alone may not innately guide impression formation about a target. Rather, the connection of that claim to perceptions of a target’s offline self should be driven by several antecedents. The reported experiment tested the antecedent factors of third-party claims with respect to perceptions and behavioral intentions toward a course instructor. Undergraduate students in the United States ( N = 209) viewed a hypothetical professor-rating website reflecting a 2 (target reply: present or absent) × 2 (rater identifiability: identifiable or anonymous) × 2 (number of ratings: many or few) × 2 (average rating: present or absent) experimental design, and reported the characteristics they perceived the target professor to possess offline. Results of a structural equation model revealed only an individual’s ability to reply to online information influenced judgments of warranting value; but the warranting value of the online information influenced subsequent impressions of the target’s offline attributes.
Meltwater Discharge From Marine‐Terminating Glaciers Drives Biogeochemical Conditions in a Greenlandic Fjord
Authors: Kanna Naoya , Sugiyama Shin , Ando Takuto , Wang Yefan , Sakuragi Yuta , Hazumi Toya , Matsuno Kohei , Yamaguchi Atsushi , Nishioka Jun , Yamashita Youhei 
Published: November 2022

AbstractAn increasing body of work has shown the potential impacts of subglacial discharge from marine‐terminating glaciers on the marine environment around Greenland. Upwelling of nutrients associated with rising buoyant plumes near the front of marine‐terminating glaciers plays a key role in maintaining the high productivity of connected fjords. The response of protist communities to subglacial discharges into fjords nevertheless remains poorly understood. Here we show data of water properties, nutrients, and protist communities during two summers in 2018 and 2019 in a Greenlandic fjord system fed by marine‐terminating glaciers. This study included the period of intense summer melting of the Greenland Ice Sheet in 2019. The data revealed high nutrient concentrations in 2019 that were attributed to intensified upwelling of nutrients and dissolved iron into the subsurface layer. The source of the iron and the nutrients was subglacial discharge and deep fjord water, respectively. Intense glacial discharges in 2019 mitigated nitrate and phosphate limitations of phytoplankton in the fjord and resulted in an increase of chlorophyll a in the subsurface layer and growth of large diatoms. Heterotrophic protists such as dinoflagellates, tintinnids, and nanoflagellates were more abundant in the summer of 2019. We concluded that nutrient upwelling by subglacial discharges was the major driver of the structure of lower trophic levels in fjord ecosystems. We hypothesize that the more intense melting of glaciers and related increase in subglacial discharge will enhance nutrient upwelling, and increased summer productivity in fjords until the glaciers retreat and terminate on land.
Pit Crater Chains Across the Solar System: Evidence for Subterranean Tectonic Caves, Porosity and Permeability Pathways on Planetary Bodies
Authors: Wyrick D. Y. , Buczkowski D. L. 
Published: November 2022

AbstractPit crater chains are surface features comprised of linear assemblages of collapsed depressions that are identified on several solid bodies throughout the Solar System. On Earth, they have been observed to form when dilational motion on normal faults causes the overlying materials to collapse into the dilating segment of the buried fault. It has been hypothesized that pit crater chains observed on Mars, Enceladus, and various small bodies formed by the same process. Dilational fault movement can also create subsurface permeability pathways for fluid/volatile transport and trapping. Studying pit crater chains and tectonic caves on planetary bodies has implications for both in situ resource utilization and astrobiology, and should be considered as a potential driver for determining exploration targets.
The transcriptional profile of keloidal Schwann cells
Authors: Direder Martin , Wielscher Matthias , Weiss Tamara , Laggner Maria , Copic Dragan , Klas Katharina , Bormann Daniel , Vorstandlechner Vera , Tschachler Erwin , Jan Ankersmit Hendrik , Mildner Michael 
Published: November 2022

AbstractRecently, a specific Schwann cell type with profibrotic and tissue regenerative properties that contributes to keloid formation has been identified. In the present study, we reanalyzed published single-cell RNA sequencing (scRNA-seq) studies of keloids, healthy skin, and normal scars to reliably determine the specific gene expression profile of keloid-specific Schwann cell types in more detail. We were able to confirm the presence of the repair-like, profibrotic Schwann cell type in the datasets of all three studies and identified a specific gene-set for these Schwann cells. In contrast to keloids, in normal scars, the number of Schwann cells was not increased, nor was their gene expression profile distinctly different from that of Schwann cells of normal skin. In addition, our bioinformatics analysis provided evidence for a role of transcription factors of the AP1, STAT, and KLF families, and members of the IER genes in the dedifferentiation process of keloidal Schwann cells. Together, our analysis strengthens the role of the profibrotic Schwann cell type in the formation of keloids. Knowledge of the exact gene expression profile of these Schwann cells will facilitate their identification in other organs and diseases.
MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1
Authors: Zhang Xianglian , Luo Ya , Cen Yu , Qiu Xin , Li Jing , Jie Mengmeng , Yang Shiming , Qin Shanyu 
Published: November 2022

AbstractMetastasis is the dominant cause of cancer-related mortality. Metastasis-associated with colon cancer protein 1 (MACC1) has been proven to play a critical role in cancer metastasis. However, the prometastatic role of MACC1 in regulating the pancreatic cancer (PC) metastatic phenotype remains elusive. Here, we report that MACC1 is highly expressed in The Cancer Genome Atlas (TCGA) and tissue microarray (TMA) and identified as a good indicator for poor prognosis. Overexpression or knockdown of MACC1 in PC cells correspondingly promoted or inhibited pancreatic cancer cell migration and invasion in a MET proto-oncogene receptor tyrosine kinase (MET)-independent manner. Notably, knockdown of MACC1 in PC cells markedly decreased the liver metastatic lesions in a liver metastasis model. Mechanistically, MACC1 binds to the epithelial-mesenchymal transition (EMT) regulator snail family transcriptional repressor 1 (SNAI1) to drive EMT via upregulating the transcriptional activity of SNAI1, leading to the transactivation of fibronectin 1 (FN1) and the trans-repression of cadherin 1 (CDH1). Collectively, our results unveil a new mechanism by which MACC1 drives pancreatic cancer cell metastasis and suggest that the MACC1-SNAI1 complex-mediated mesenchymal transition may be a therapeutic target in pancreatic cancer.
Blockade of FGF2/FGFR2 partially overcomes bone marrow mesenchymal stromal cells mediated progression of T-cell acute lymphoblastic leukaemia
Authors: Tian Chen , Li Yueyang , Wang Lina , Si Junqi , Zheng Yaxin , Kang Junnan , Wang Yafei , You M. James , Zheng Guoguang 
Published: November 2022

AbstractThe development of acute lymphoblastic leuakemia (ALL) is partly attributed to the effects of bone marrow (BM) microenvironment, especially mesenchymal stromal cells (MSCs), which interact bilaterally with leukaemia cells, leading to ALL progression. In order to find MSCs-based microenvironment targeted therapeutic strategies, Notch1-induced T-cell ALL (T-ALL) mice models were used and dynamic alterations of BM-MSCs with increased cell viability during T-ALL development was observed. In T-ALL mice derived stroma-based condition, leukaemia cells showed significantly elevated growth capacity indicating that MSCs participated in leukaemic niche formation. RNA sequence results revealed that T-ALL derived MSCs secreted fibroblast growth factor 2 (FGF2), which combined with fibroblast growth factor receptor 2 (FGFR2) on leukaemia cells, resulting in activation of PI3K/AKT/mTOR signalling pathway in leukaemia cells. In vitro blocking the interaction between FGF2 and FGFR2 with BGJ398 (infigratinib), a FGFR1-3 kinase inhibitor, or knockdown FGF2 in MSCs by interference caused deactivation of PI3K/AKT/mTOR pathway and dysregulations of genes associated with cell cycle and apoptosis in ALL cells, leading to decrease of leukaemia cells. In mouse model received BGJ398, overall survival was extended and dissemination of leukaemia cells in BM, spleen, liver and peripheral blood was decreased. After subcutaneous injection of primary human T-ALL cells with MSCs, tumour growth was suppressed when FGF2/FGFR2 was interrupted. Thus, inhibition of FGF2/FGFR2 interaction appears to be a valid strategy to overcome BM-MSCs mediated progression of T-ALL, and BGJ398 could indeed improve outcomes in T-ALL, which provide theoretical basis of BGJ398 as a BM microenvironment based therapeutic strategy to control disease progression.
Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through immune landscape analysis
Authors: Shigemizu Daichi , Akiyama Shintaro , Mitsumori Risa , Niida Shumpei , Ozaki Kouichi 
Published: November 2022

AbstractMild cognitive impairment (MCI) is a clinical precursor of Alzheimer’s disease (AD). Recent genetic studies have reported on associations between AD risk genes and immunity. Here, we obtained samples and data from 317 AD, 432 MCI, and 107 cognitively normal (CN) subjects and investigated immune-cell type composition and immune clonal diversity of T-cell receptor (TRA, TRB, TRG, and TRD) and B-cell receptor (IGH, IGK, and IGL) repertoires through bulk RNA sequencing. We found the proportions of plasma cells, γδ T cells, neutrophils, and B cells were significantly different and the diversities of IGH, IGK, and TRA were significantly small with AD progression. We then identified a differentially expressed gene, WDR37, in terms of risk of MCI-to-AD conversion. Our prognosis prediction model using the potential blood-based biomarkers for early AD diagnosis, which combined two immune repertoires (IGK and TRA), WDR37, and clinical information, successfully classified MCI patients into two groups, low and high, in terms of risk of MCI-to-AD conversion (log-rank test P = 2.57e-3). It achieved a concordance index of 0.694 in a discovery cohort and of 0.643 in an independent validation cohort. We believe that further investigation, using larger sample sizes, will lead to practical clinical use in the near future.
Revised monthly energy generation estimates for 1,500 hydroelectric power plants in the United States
Authors: Turner Sean W. D. , Voisin Nathalie , Nelson Kristian 
Published: November 2022

AbstractThe U.S. Energy Information Administration (EIA) conducts a regular survey (form EIA-923) to collect annual and monthly net generation for more than ten thousand U.S. power plants. Approximately 90% of the ~1,500 hydroelectric plants included in this data release are surveyed at annual resolution only and thus lack actual observations of monthly generation. For each of these plants, EIA imputes monthly generation values using the combined monthly generating pattern of other hydropower plants within the corresponding census division. The imputation method neglects local hydrology and reservoir operations, rendering the monthly data unsuitable for various research applications. Here we present an alternative approach to disaggregate each unobserved plant’s reported annual generation using proxies of monthly generation—namely historical monthly reservoir releases and average river discharge rates recorded downstream of each dam. Evaluation of the new dataset demonstrates substantial and robust improvement over the current imputation method, particularly if reservoir release data are available. The new dataset—named RectifHyd—provides an alternative to EIA-923 for U.S. scale, plant-level, monthly hydropower net generation (2001–2020). RectifHyd may be used to support power system studies or analyze within-year hydropower generation behavior at various spatial scales.
A combined microbial and biogeochemical dataset from high-latitude ecosystems with respect to methane cycle
Authors: Barret Maialen , Gandois Laure , Thalasso Frederic , Martinez Cruz Karla , Sepulveda Jauregui Armando , Lavergne Céline , Teisserenc Roman , Aguilar Polette , Gerardo Nieto Oscar , Etchebehere Claudia , Martins Dellagnezze Bruna , Bovio Winkler Patricia , Fochesatto Gilberto J. , Tananaev Nikita , Svenning Mette M. , Seppey Christophe , Tveit Alexander , Chamy Rolando , Astorga España María Soledad , Mansilla Andrés , Van de Putte Anton , Sweetlove Maxime , Murray Alison E. , Cabrol Léa 
Published: November 2022

AbstractHigh latitudes are experiencing intense ecosystem changes with climate warming. The underlying methane (CH4) cycling dynamics remain unresolved, despite its crucial climatic feedback. Atmospheric CH4emissions are heterogeneous, resulting from local geochemical drivers, global climatic factors, and microbial production/consumption balance. Holistic studies are mandatory to capture CH4cycling complexity. Here, we report a large set of integrated microbial and biogeochemical data from 387 samples, using a concerted sampling strategy and experimental protocols. The study followed international standards to ensure inter-comparisons of data amongst three high-latitude regions: Alaska, Siberia, and Patagonia. The dataset encompasses different representative environmental features (e.g. lake, wetland, tundra, forest soil) of these high-latitude sites and their respective heterogeneity (e.g. characteristic microtopographic patterns). The data included physicochemical parameters, greenhouse gas concentrations and emissions, organic matter characterization, trace elements and nutrients, isotopes, microbial quantification and composition. This dataset addresses the need for a robust physicochemical framework to conduct and contextualize future research on the interactions between climate change, biogeochemical cycles and microbial communities at high-latitudes.
Imaging and histological features of tumor biopsy sample predict aggressive intrasegmental recurrence of hepatocellular carcinoma after radiofrequency ablation
Authors: Gigante Elia , Haddad Yohann , Nault Jean-Charles , Sutter Olivier , Abou Ali Einas , Bonnet Baptiste , N’Kontchou Gisèle , Grando Veronique , Ganne-Carrié Nathalie , Nahon Pierre , Blaise Lorraine , Calderaro Julien , Barget Nathalie , Seror Olivier , Ziol Marianne 
Published: November 2022

AbstractAggressive intrasegmental recurrence (AIR) is a form of local recurrence associated with a dismal prognosis and defined by multiple nodules or by an infiltrative mass with a tumor thrombus, occurring in the treated segment, after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). We aimed to identify radiological and/or histological characteristics of tumor biopsy predictive of AIR. We retrospectively analyzed patients treated by No-Touch multi-bipolar RFA (mbpRFA) for a first HCC with a systematic per-procedural tumor biopsy positive for diagnosis of HCC. The first recurrence was classified as non-aggressive local recurrence, AIR or intrahepatic distant recurrence. 212 patients were included (168 men; mean age 67.1 years; mean tumor size 28.6 mm, 181 cirrhosis). AIR occurred in 21/212 patients (10%) and was associated with a higher risk of death (57% in patients with AIR vs 30% without AIR, p = 0.0001). Non-smooth tumor margins, observed in 21% of the patients and macro-trabecular massive histological subtype, observed in 12% of the patients were independently related to a higher risk of AIR (HR: 3.7[1.57;9.06], p = 0.002 and HR:3.8[2.47;10], p = 0.005 respectively). Non smooth margins at imaging and macro-trabecular massive histological subtype are associated with AIR and could be considered as aggressive features useful to stratify therapeutic strategy.
Founder lineages in the Iberian Roma mitogenomes recapitulate the Roma diaspora and show the effects of demographic bottlenecks
Authors: Aizpurua-Iraola Julen , Giménez Aaron , Carballo-Mesa Annabel , Calafell Francesc , Comas David 
Published: November 2022

AbstractThe Roma are the largest ethnic minority in Europe. With a Northwestern Indian origin around ~ 1.5 kya, they travelled throughout West Asia until their arrival in Europe around the eleventh century CE. Their diaspora through Europe is characterized by population bottlenecks and founder events which have contributed to their present day genetic and cultural diversity. In our study, we focus on the effects of founder effects in the mitochondrial DNA (mtDNA) pool of Iberian Roma by producing and analyzing 144 novel whole mtDNA sequences of Iberian Roma. Over 60% of their mtDNA pool is composed by founder lineages of South Asian origin or acquired by gene flow during their diaspora in the Middle East or locally in Europe in Europe. The TMRCA of these lineages predates the historical record of the Roma arrival in Spain. The abundance of founder lineages is in contrast with ~ 0.7% of autochthonous founder lineages present in the non-Roma Iberian population. Within those founder lineages, we found a substantial amount of South Asian M5a1b1a1 haplotypes and high frequencies of West Eurasian founder lineages (U3b1c, J2b1c, J1c1b, J1b3a, H88, among others), which we characterized phylogenetically and put in phylogeographical context. Besides, we found no evidence of genetic substructure of Roma within the Iberian Peninsula. These results show the magnitude of founder effects in the Iberian Roma and further explain the Roma history and genetic diversity from a matrilineal point of view.