bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Different Intensities and Durations of Aerobic Exercise on Vascular Endothelial Function in Middle-Aged and Elderly People: A Meta-analysis
Authors: You Qiuping , Yu Laikang , Li Gen , He Hui , Lv Yuanyuan 
Published: January 2022

BackgroundPrevious studies have found that aerobic exercise was more effective in improving vascular endothelial function than resistance training, high-intensity interval training (HIIT), and other types of exercise, while the effects between different intensities and durations of aerobic exercise were unclear. Therefore, we performed this meta-analysis to investigate the effects of different intensities and durations of aerobic exercise on the vascular endothelial function of middle-aged and elderly people.Methods:Databases were searched up to April 2021 for studies evaluating the influences of different intensities and durations of aerobic exercise on endothelial function assessed by flow-mediated dilation (FMD) among healthy middle-aged and elderly people. Data were pooled using random-effects models to obtain the weighted mean difference (WMD) and 95% confidence intervals (CIs).ResultsA total of 9 studies involving 221 participants fulfilled the inclusion criteria. Aerobic exercise improved the overall FMD of healthy middle-aged and elderly people [WMD, 1.33 (95% CI, 0.37–2.28), P &lt; 0.05]. Specifically, vigorous-intensity exercise increased FMD significantly in healthy middle-aged and elderly people [WMD, 1.10 (95% CI, 0.27–1.93), P &lt; 0.05], while moderate-intensity exercise had no significant association with FMD [WMD, 1.49 (95% CI, −0.62 to 3.60), P = 0.17]. In addition, long-term (8 weeks or above) aerobic exercise increased the FMD in healthy middle-aged and elderly people [WMD, 1.63 (95% CI, 0.61–2.66), P &lt; 0.05], while one-time acute aerobic exercise had no significant association with FMD of healthy middle-aged and elderly people [WMD, 0.89 (95% CI, −1.47 to 3.24), P = 0.46]. Specifically, 8 weeks or above of vigorous-intensity exercise increased FMD significantly in healthy middle-aged and elderly people [WMD, 1.48 (95% CI, 1.06–1.90), P &lt; 0.01], while 8 weeks or above of moderate aerobic exercise had no significant association with FMD [WMD, 1.49 (95% CI, −0.62 to 3.60), P = 0.17].ConclusionAerobic exercise, especially 8 weeks or above of vigorous-intensity aerobic exercise, improved the endothelial function in healthy middle-aged and elderly people.
Assessing and Optimizing Socio-Moral Reasoning Skills: Findings From the MorALERT Serious Video Game
Authors: Zarglayoun Hamza , Laurendeau-Martin Juliette , Tato Ange , Vera-Estay Evelyn , Blondin Aurélie , Lamy-Brunelle Arnaud , Chaieb Sameh , Morasse Frédérick , Dufresne Aude , Nkambou Roger , Beauchamp Miriam H. 
Published: January 2022

BackgroundSocial cognition and competence are a key part of daily interactions and essential for satisfying relationships and well-being. Pediatric neurological and psychological conditions can affect social cognition and require assessment and remediation of social skills. To adequately approximate the complex and dynamic nature of real-world social interactions, innovative tools are needed. The aim of this study was to document the performance of adolescents on two versions of a serious video game presenting realistic, everyday, socio-moral conflicts, and to explore whether their performance is associated with empathy or sense of presence, factors known to influence social cognition.MethodsParticipants (12–17 years, M = 14.39; SD = 1.35) first completed a pre-test measure of socio-moral reasoning based on three dilemmas from a previously validated computer task. Then, they either played an evaluative version (n = 24) or an adaptive (n = 33) version of a video game presenting nine social situations in which they made socio-moral decisions and provided justifications. In the evaluative version, participants’ audio justifications were recorded verbatim and coded manually to obtain a socio-moral reasoning maturity score. In the adaptive version (AV), tailored feedback and social reinforcements were provided based on participant responses. An automatic coding algorithm developed using artificial intelligence was used to determine socio-moral maturity level in real-time and to provide a basis for the feedback and reinforcements in the game. All participants then completed a three-dilemma post-test assessment.ResultsThose who played the adaptive version showed improved SMR across the pre-test, in-game and post-test moral maturity scores, F(1.97,63.00) = 9.81, pHF &lt; 0.001, ϵ2 = 0.21, but those who played the Evaluative version did not. Socio-moral reasoning scores from both versions combined did not correlate with empathy or sense of presence during the game, though results neared significance. The study findings support preliminary validation of the game as a promising method for assessing and remediating social skills during adolescence.
Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis
Authors: Kwok Susanna S. , Nguyen Xuan-Mai T. , Wu Diana D. , Mudar Raksha A. , Llano Daniel A. 
Published: January 2022

An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered to reveal an association. Therefore, in the current report, we sought to estimate the degree to which AD patients have impaired hearing by performing a meta-analysis to increase statistical power. We reviewed 248 published studies that quantified peripheral hearing function using pure-tone audiometry for subjects with AD. Six studies, with a combined total of 171 subjects with AD compared to 222 age-matched controls, met inclusion criteria. We found a statistically significant increase in hearing threshold as measured by pure tone audiometry for subjects with AD compared to controls. For a three-frequency pure tone average calculated for air conduction thresholds at 500–1,000–2,000 Hz (0.5–2 kHz PTA), an increase of 2.3 decibel hearing level (dB HL) was found in subjects with AD compared to controls (p = 0.001). Likewise, for a four-frequency pure tone average calculated at 500–1,000–2,000–4,000 (0.5–4 kHz PTA), an increase of 4.5 dB HL was measured (p = 0.002), and this increase was significantly greater than that seen for 0.5–2 kHz PTA. There was no difference in the average age of the control and AD subjects. These data confirm the presence of poorer hearing ability in AD subjects, provided a quantitative estimate of the magnitude of hearing loss, and suggest that the magnitude of the effect is greater at higher sound frequencies.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier: CRD42021288280.
Attenuated Psychotic Symptoms in Adolescents With Chronic Cannabis and MDMA Use
Authors: Wiedmann Melina , Kuitunen-Paul Sören , Basedow Lukas A. , Roessner Veit , Golub Yulia 
Published: January 2022

ObjectivesBoth substance use, on the one hand, and the first signs of psychosis, on the other, commonly begin in adolescence. Adolescents with substance use disorder (SUD) frequently show recreational use of cannabis and 3,4-methylenedioxymethamphetamine (MDMA). When attenuated psychotic symptoms (APS) occur during the course of SUD, they are commonly attributed to the cannabis use, neglecting the role of other substances abused, such as MDMA in the risk of psychosis.MethodsWe analyzed retrospective self-reports on APS (Prodromal Questionnaire, PQ-16) and amount of cannabis and MDMA use in n = 46 adolescent psychiatry outpatients with SUD. N = 17 (35%) individuals reported MDMA consume additional to cannabis. Furthermore, we examined the associations of APS with cannabis and MDMA use in stepwise hierarchical regressions while controlling for trauma history, birth complications and gender.ResultsAPS were not related to cannabis (B = 0.04, p = 0.842), but to MDMA use (B = 4.88, p = 0.001) and trauma history (B = 0.72, p = 0.001). Gender (B = −0.22, p = 0.767) and birth complications (B = −0.68, p = 0.178) were not associated with APS.DiscussionOur results indicate that MDMA use additional to cannabis use is associated with APS among adolescent SUD patients. Contrary to our expectations, we did not see an association of cannabis use and APS. We speculate that cannabis increases the risk for psychosis after a longer period of use and in combination with other risk factors, such as trauma history. Clinicians should screen for APS among SUD patients using MDMA and cannabis in order to adapt treatment plans of SUDs. Future research should validate these findings in longitudinal studies including polysubstance use and trauma history.
Attachment Styles, Personality Organization, and Substance Use as Predictors of Emotion Regulation Strategies “Suppression” and “Reappraisal” in Young Adults
Authors: Burgkart Pauline L. , Vuzic Xenia , Fuchshuber Jürgen , Unterrainer Human-Friedrich 
Published: January 2022

BackgroundAs evidenced by current literature, there is a crucial link between emotion regulation, attachment, personality patterns, and substance abuse. However, knowledge regarding the exact interactions of these specific parameters in terms of substance abuse development is still sparse. Therefore, this study is aimed to shed light on how two specific emotion regulation strategies (“Reappraisal” and “Suppression”) might be influenced by the relationship between attachment, structural deficits in personality organization, and addictive behaviors.MethodA total sample of 299 non-clinical young adults (Age: M = 22; SD = 3.81; 74.2% females) filled in the Emotion Regulation Questionnaire (ERQ) together with the Adult Attachment Scale (AAS), the Personality Organization Inventory (IPO-16), and the Alcohol, Smoking and Substance Involvement Screening (ASSIST) by means of an online survey.ResultsAs suggested by hierarchical regression analysis, attachment specifically predicted differences in Emotion Regulation (ER), whereby the AAS subscales “Close” ness (β = −0.38, p &lt; 0.01) and “Depend” ence (β = –0.18, p &lt; 0.01) were negatively associated with increased use of maladaptive strategies of expressional suppression of emotion, and “Depend” (β = 0.26, p &lt; 0.01) was positively associated with increased use of adaptive strategies of cognitive reappraisal.DiscussionIn line with our assumptions, we observed a more secure attachment system to be predictive for an increased use of adequate emotion regulation strategies. The findings support the suggestion that a focus on underlying attachment-related processes in a psychotherapeutic setting might be a promising way to promote adaptive self-regulation of emotions.
Uncertainty and Fears Around Sustainability: A Qualitative Exploration of the Emotional Reactions of Dental Practitioners and Dental Care Professionals During COVID-19
Authors: Knights Jennifer , Beaton Laura , Young Linda , Araujo Mariana , Yuan Siyang , Clarkson Jan , Humphris Gerry , Freeman Ruth 
Published: January 2022

IntroductionRecent cross-sectional surveys have shown the detrimental impact of COVID-19 on the health and well-being of dental practitioners and dental care professionals. This qualitative study complements the growing quantitative evidence base with an in-depth exploration of the lived experiences of those working in primary care dental teams in Scotland.MethodsFocus groups were carried out with primary care dental team members and trainees between July and October 2020. Olsen's tripartite framework of health service sustainability was operationalised to explore how participants experienced uncertainty and their attempts to sustain dental services.ResultsAnalysis revealed significant concerns surrounding the sustainability of dental services and dental training programmes as a consequence of the emergency level response to the pandemic. Restrictions on dentistry were seen to be severely impeding desirable clinical outcomes, particularly for the most vulnerable groups. Participants experienced being unable to deliver high quality care to their patients as both confusing and distressing. The capability of the dental health care system to meet a growing backlog of dental need and manage this effectively in a pandemic era was called in to serious question. Ongoing uncertainties were affecting how participants were thinking about their professional futures, with stress about income and employment, along with heightened experiences of professional isolation during the pandemic, resulting in some looking at possibilities for retraining or even considering leaving their profession altogether.DiscussionThe impact of the pandemic has produced considerable uncertainty regarding the sustainability of dental services in the medium to longer term. It has also served to expose the uncertainties practitioners grapple with routinely as they attempt to sustain their NHS dental service delivery.ConclusionThis study brings in to sharp focus the diversity of challenges, confusions and uncertainties experienced by dental practitioners and dental care professionals during the COVID-19 pandemic and the need for suitable and ongoing measures to be put in place to support their mental well-being.
The Relationships among Microelement Composition of Reindeer Meat (Rangifer tarandus) and Adaptation: A Systematic Review and Meta-Analysis
Authors: Andronov Sergei , Lobanov Andrey , Bogdanova Elena , Popov Andrei , Yuzhakov Alexander , Shaduyko Olga , Raheem Dele , Kobelkova Irina 
Published: January 2022

This systematic review and meta-analysis based on PRISMA statements aimed to summarise the data on the chemical composition of reindeer meat depending on the region of the Rangifer tarandus. We searched SCOPUS, PubMed, Embase, CrossRef, Medline, Cochrane library, eLibrary, and CyberLeninka. A total of 3310 records published between January 1980 and December 2021 were screened. We identified 34 relevant studies conducted in Russia, Norway, the USA, Canada, and Finland for the synthesis. Overall, the consumption of reindeer meat reduces arterial hypertension and atherosclerosis due to many polyunsaturated fatty acids (linoleic, linolenic, arachidonic) and vitamin C, which balances lipid fractions. Venison is an effective means of preventing obesity and adapting to cold due to the content of a complete set of essential trace elements, amino acids, and even L-carnitine. The high content of vitamin C and microelements (iron, zinc, copper) in reindeer meat is likely to increase the body’s antioxidant defence against free radicals and help prevent chronic non-infectious diseases. Thus, venison is an essential component of the adaptation mechanism for the Arctic population.
The morphological and functional relationship between dental pulp and periodontal tissue in the aspect of endo-perio lesions
Authors: Moiseev D. A. , Volkov S. I. , Konov A. A. , Kulyukina M. A. 
Published: January 2022

Relevance. The growing prevalence of combined endo-perio lesions (EPL) attracts the interest of researchers. Insufficiently covered in the scientific literature, issues of the anatomical and functional relationship between periodontal tissues and dental pulp, the lack of an algorithm for diagnosis and treatment of EPL determine the need for their research. The study aimed to arrange the available data on the morpho-functional aspects of the relationship between dental pulp and periodontal tissues and their features that determine the p athogenesis of EPL.Materials and methods. The study found 2875 publications, presented in the international electronic scientific databases PubMed, Google Search, Embase, Web of Science, ScienceDirect, SciELO and eLibrary. Following the inclusion and non-inclusion criteria, we selected 52 publications, which included the results on studying the structure and function of periodontal tissues, roots and pulp of teeth in the aspect of EPL development. The methodology of this study meets the criteria for systematic reviews and meta-analyses (PRISMA).Results. In EPL lesions, inflammation is maintained by an infection, which persists in the additional root canals and dentinal tubules and the periodontal pocket. Prevention of the formation and elimination of infection foci in the root canal system of the tooth, periapical tissues and periodontal pockets is the basis for EPL prevention and treatment. At the same time, there are no diagnostic and therapeutic algorithms, which allow timely detection of EPL and adequate treatment, depending on the primary lesion of pulpal and periodontal tissues and individual characteristics of the patient. The structure specifics of roots, pulp, cementum, periodontium and alveolar bone are described. The characteristic features of blood supply and innervation of the pulpal and periodontal tissues are presented. Promising areas of scientific research in EPL prevention and treatment are identified.Conclusion. Tooth pulp and periodontal tissues are closely related morphologically and functionally. They are principally connected through the apical foramina and additional canals. Bacterial infection can also penetrate the pulp and periodontal tissues from the infected root canal system of the tooth through the dentinal tubules of the tooth root.
IMPLEMENTASI WEB ELEKTRONIK (E-COMMERCE) DI TOKO PECAH BELAH CENTER DALAM MENINGKATKAN PERSAINGAN BISNIS PERDAGANGAN
Authors: Marini Marini , Sarwindah Sarwindah 
Published: January 2022

Abstract - Implementation of Electronic Web (E-Commerce) that can make transactions for the community and increase trade. Electronic Web Implementation (E-Commerce) uses the OOAD method (Object Oriented Analysis Design). The development phase of design modeling uses problem analysis, and application marketing needs, process model design, data model design, application program creation, application implementation. This research serves to find out that internet usage in the present time has experienced significant development and benefits in the business field. This is mainly felt by large scale companies. The main objectives of its implementation can improve the efficiency and effectiveness of the company, especially for the smooth running of business processes. The results of trials and evaluations conducted on E-Commerce web applications can increase product sales and increase business competition.Keywords - Web, E-commerce, OOAD, Implementasi, MySql Abstract - Implementasi Web Elektronik ( E-Commerce) yang dapat mempermudah melakukan transaksi pembelian bagi masyarakat dan meningkatkan perdagangan. Implementasi Web Elektronik ( E-Commerce) menggunakan metode OOAD(Object Oriented Analisis Design). Tahapan pengembangan Pemodelan desain menggunakan analisis permasalahan, dan kebutuhan aplikasi pemasaran, desain model proses, desain model data, pembuatan program aplikasi, implementasi aplikasi. Penelitian ini berfungsi untuk mengetahui Penggunaan internet di masa kini sudah mengalami perkembangan dan pemberian manfaat yang signifikan pada bidang bisnis. Hal ini terutama dirasakan oleh perusahaan skala besar. Sasaran utama implementasinya mampu meningkatkan efisiensi dan efektivitas perusahaan terutama bagi kelancaran proses bisnis. Hasil uji coba dan evaluasi yang dilakukan pada aplikasi web E-Commerce ini mampu meningkatkan penjualan produk dan meningkatkat persaingan bisnis perusahaanKata kunci - Web, E-commerce, OOAD, Implementasi, MySql
IMPLEMENTASI METODE FORWARD CHAINING UNTUK DIAGNOSA PENYAKIT COVID 19 DI RSUD BERKAH PANDEGLANG BANTEN
Authors: Rizky Robby , Sukisno Sukisno , Ridwan Mohammad , Hakim Zaenal 
Published: January 2022

Abstract - In 2020 there was an explosion of viruses that shocked the world, that we call Corona Virus Disease 2019. This virus is the development of the Mers virus (Middle East Respiratory Syndrome Corona Virus). COVID-9 can spread quickly compared to the Mers virus. The problem in Pandeglang Regency is the lack of medical personnel and medical devices. This is because Pandeglang Regency is an underdeveloped region among other regencies in Banten Province. Therefore, this research is intended to be able to help check patients who have positive Covid-19. The method used is the forward chaining method which is considered simple but easy to be understood. This method uses a continuous trace system that will detect every symptom experienced by the patient. The data used in the form of a questionnaire the results of interviews with experts in their fields. This research is expected to be able to contribute to Pandeglang Regency and break the chain of the spread of Covid-19 in underdeveloped regions that are difficult to get medical personnel and adequate equipment. The conclusion of this research is the forward chaining method can solve this problem.Keywords – Implementation, Forward Chaining Method, Covid-19, Berkah Pandeglang District Hospital (RSUD Berkah Pandeglang) Abstrak – Pada tahun 2020 terjadi begitu maraknya virus yang menggemparkan dunia yaitu Coronavirus Disease 2019. Virus ini merupakan pengembangan dari virus MERS (middle East Respiratory Syndrome Corona Virus). Covid-9 dapat menularkan dengan cepat dibandingkan virus Mers. Permasalahan yang ada di Kabupaten Pandeglang yaitu kurangnya tenaga medis dan alat kesehatan. Hal ini dikarenakan Kabupten Pandeglang merupakan daerah tertinggal di antara kabupaten lainnya yang ada di Provinsi Banten. Maka dari itu, penelitian ini ditujukan untuk dapat membantu pengecekan pasien yang terjangkit positif Covid-19. Adapun metode yang digunakan adalah metode forward chaining yang dianggap sederhana namun mudah untuk dipahami. Metode ini menggunakan system runut maju yang akan mendeteksi setiap gejala yang dialami pasien. Data yang digunakan yaitu berupa kuesioner hasil wawancara dengan para pakar dibidangnya. Penelitian ini diharapkan dapat memberikan kontribusi terhadap Kabupaten Pandeglang dan memutus rantai penyebaran Covid-19 di daerah tertinggal yang sulit mendapatkan tenaga medis dan peralatan yang memadai. Kesimpulan dari penelitian ini metode forward chaining dapat memecahkan permasalahan tersebut.Kata kunci – Implimentasi, Metode Forward Chaining, Covid-19, RSUD Berkah Pandeglang