bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Predictors of Engagement in Teleintegrated Care and Telereferral Care for Complex Psychiatric Disorders in Primary Care: a Randomized Trial
Authors: Severe Jennifer , Pfeiffer Paul N. , Palm-Cruz Katherine , Hoeft Theresa , Sripada Rebecca , Hawrilenko Matthew , Chen Shiyu , Fortney John 
Published: February 2022

AbstractBackgroundTelepsychiatry Collaborative Care (TCC) and Telepsychiatry/Telepsychology Enhanced Referral (TER) expand the reach of specialty mental health services to underserved populations.ObjectiveAssess clinical predictors of treatment engagement for complex psychiatric conditions in TCC—in which remote specialists consult with primary care teams via an onsite care manager who also provides brief psychotherapy—and TER, in which remote specialists provide direct telehealth treatment.DesignA randomized pragmatic trial from twenty-four primary care clinics without onsite psychiatrists or psychologists.ParticipantsA total of 1,004 adult patients screened positive for posttraumatic stress disorder (PTSD)and/or bipolar disorder were randomized to receive TCC or TER for 1 year.Main MeasuresPsychotherapy engagement was measured by the number of sessions completed, and pharmacotherapy engagement by the medication adherence item from the Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ).Key ResultsEngagement in TCC psychotherapy visits was greater compared to TER. There was no association between the PTSD symptom severity and treatment engagement. The internal state scale (ISS) activation subscale, an indicator of mania, was associated with reduced odds of initiating psychotherapy (odds ratio [OR] = 0.70; 95% CI, 0.59 to 0.84) but not the number of sessions attended once psychotherapy started. The Drug Abuse Screening Test-10(DAST-10) score was associated with receipt of fewer psychotherapy sessions (incidence ratio rate [IRR] = 0.88; 95% CI, 0.81 to 0.95). The number of physical health comorbidities was associated with greater engagement in psychotherapy (IRR = 1.11, 95% CI, 1.03 to 1.19) and pharmacotherapy (OR = 1.54; 95% CI, 1.27 to 1.87). None of the findings varied by intervention group.ConclusionsBoth teleintegrated and telereferral care offer an opportunity to treat patients with complex psychiatric conditions. While there was no difference in clinical characteristics predicting engagement, onsite care managers engaged patients in more psychotherapy sessions than remote therapists.Trial RegistrationClinicalTrials.govIdentifier: NCT02738944
Advances and safe use of energy devices in lung cancer surgery
Authors: Homma Takahiro 
Published: February 2022

Abstract
Objectives
A clear understanding of energy devices would help achieve high effectiveness and safety and guide the selection of devices. The present review aimed to elucidate the efficacy and adverse events of energy devices in lung cancer to guide the selection of appropriate devices depending on the situation.

Methods
Four major databases were searched electronically for relevant articles published until 16 April 2021. The reference lists of the identified papers were examined. We excluded (1) irrelevant studies, (2) manuscripts published in languages other than English and Japanese, (3) duplicates, and (4) studies for which the full text was not available in the databases. The results and key information obtained were summarized by means of a narrative approach.

Results
A total of 78 papers were included in the review and these were categorized according to the main topic of investigation as follows: (1) electrosurgery-related injuries, (2) fundamentals of electrosurgery, (3) monopolar devices, (4) bipolar electrosurgical devices, (5) ultrasonic energy devices, (6) energy devices in lung cancer surgery, (7) operating room fire risks, and (8) basic principles of surgery.

Conclusions
Understanding energy devices could help us use them in a more effective and safer manner. Knowledge of their selection criteria (suitability), merits, risks, and safety precautions relevant to each process of lung cancer surgery could guide appropriate selection.
Informing the delivery of cancer survivorship care in rural primary care practice
Authors: Klemp J. R. , Knight C. J. , Lowry B. , Long T. , Bush C. , Alsman K. , Krebill H. , Peereboom D. , Overholser L. , Greiner K. A. 
Published: February 2022

Abstract
Purpose
The cancer survivor population is projected to increase to 22.2 million by 2030, requiring improved collaboration between oncology and primary care practices (PCP). PCPs may feel ill-equipped to provide cancer survivorship care to patients without input from cancer specialists. Compared with nonrural cancer survivors, rural cancer survivors report experiencing worse treatment-related symptoms. The goal of this study was to gain a better understanding of the perspectives of PCP teams towards survivorship care and to develop and test an interdisciplinary training program to improve cancer survivorship care in rural practice.

Methods
This study was conducted in two phases. First, focus groups were conducted with rural PCP teams to gather information regarding beliefs, practices, and barriers related to cancer survivorship care delivery. A thematic analysis was completed using an iterative process of reviewing transcripts. Results from phase 1 were used to inform the development of a pilot intervention tested within seven rural PCPs (phase 2). Pre- and post-intervention knowledge changes were compared, and post-session interviews assessed planned or sustained practice changes.

Results
Seven PCPs participated in focus groups (phase 1). Cross-cutting themes identified included (1) organizational barriers affecting the delivery of cancer survivorship care, (2) challenges of role delineation with specialists and patients, (3) difficulty accessing survivorship care and resources, and (4) providers’ lack of knowledge of cancer survivorship care. For phase 2, seven practices participated in four case-based educational sessions. Within and between practice changes were identified.

Conclusion
This project explored cancer survivorship perspectives among PCP teams. Lack of familiarity with evidence-based guidelines and the inability to identify cancer survivors was apparent during discussions and led to the implementation of the phase 2 intervention, iSurvive. As a result, PCPs either changed or planned changes to improve the identification and evidence-based care of cancer survivors.

Implications for Cancer Survivors
Address barriers to access cancer survivorship care in rural primary care practices.
Priority recommendations for the implementation of patient-reported outcomes in clinical cancer care: a Delphi study
Authors: Mazariego C. , Jefford M. , Chan R. J. , Roberts N. , Millar L. , Anazodo A. , Hayes S. , Brown B. , Saunders C. , Webber K. , Vardy J. , Girgis A. , Koczwara B. ,   on behalf of the COSA PRO Working Group
Published: February 2022

AbstractPurposeThe aim of this study was to develop priority recommendations for the service level implementation of patient-reported outcomes (PROs) into clinical cancer care.MethodsDevelopment of draft guidance statements was informed by a literature review, the Knowledge to Action (KTA) implementation framework, and discussion with PRO experts and cancer survivors. A two-round modified Delphi survey with key stakeholders including cancer survivors, clinical and research experts, and Information Technology specialists was undertaken. Round 1 rated the importance of the statements and round 2 ranked statements in order of priority.ResultsRound 1 was completed by 70 participants with round 2 completed by 45 participants. Forty-seven statements were rated in round 2. In round 1, the highest agreement items (>90% agreement) included those that focused on the formation of strong stakeholder partnerships, ensuring ongoing communication within these partnerships, and the use of PROs for improvement and guidance in clinical care. Items ranked as the highest priorities in round 2 included assessment of current staff capabilities and service requirements, mapping of workflows and processes to enable collection, and using collected PROs to guide improved health outcomes.ConclusionsThis stakeholder consultation process has identified key priorities in PRO implementation into clinical cancer care that include clinical relevance, stakeholder engagement, communication, and integration within the existing processes and capabilities.Implication for Cancer SurvivorsRoutine adoption of PRO collection by clinical cancer services requires multiple implementation steps; of highest priority is strong engagement and communication with key stakeholders including cancer survivors.
MRI-Guided Cardiac Catheterization in Congenital Heart Disease: How to Get Started
Authors: Amin Elena K. , Campbell-Washburn Adrienne , Ratnayaka Kanishka 
Published: February 2022

Abstract
Purpose of Review
Cardiac magnetic resonance imaging provides radiation-free, 3-dimensional soft tissue visualization with adjunct hemodynamic data, making it a promising candidate for image-guided transcatheter interventions. This review focuses on the benefits and background of real-time magnetic resonance imaging (MRI)-guided cardiac catheterization, guidance on starting a clinical program, and recent research developments.

Recent Findings
Interventional cardiac magnetic resonance (iCMR) has an established track record with the first entirely MRI-guided cardiac catheterization for congenital heart disease reported nearly 20 years ago. Since then, many centers have embarked upon clinical iCMR programs primarily performing diagnostic MRI-guided cardiac catheterization. There have also been limited reports of successful real-time MRI-guided transcatheter interventions. Growing experience in performing cardiac catheterization in the magnetic resonance environment has facilitated practical workflows appropriate for efficiency-focused cardiac catheterization laboratories. Most exciting developments in imaging technology, MRI-compatible equipment and MRI-guided novel transcatheter interventions have been limited to preclinical research. Many of these research developments are ready for clinical translation.

Summary
With increasing iCMR clinical experience and translation of preclinical research innovations, the time to make the leap to radiation-free procedures is now.
Central Nervous System Impact of Perinatally Acquired HIV in Adolescents and Adults: an Update
Authors: Nichols Sharon L. 
Published: February 2022

Abstract
Purpose of Review
Perinatally acquired HIV infection (PHIV) can confer neurodevelopmental risk. As children with PHIV increasingly survive through adolescence and into adulthood, understanding its long-term central nervous system (CNS) impacts is critical for maximizing adult outcomes and quality of life.

Recent Findings
Recently published neurocognitive and neuroimaging findings show impacts on the CNS associated with early HIV disease progression that endure into adolescence and young adulthood. Although developmental trajectories in adolescence largely appear stable, further research on maturational processes is indicated.

Summary
Although early antiretroviral therapy in infancy appears to be protective, it is not universally available and current youth largely developed without its benefit. The neurocognitive effects of HIV and the multiple other risks to neurodevelopment experienced by youth with PHIV call for further longitudinal research and a multifaceted approach to prevention and intervention.
A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries
Authors: Tsoumpeli Maria T. , Gray Alison , Parsons Aimee L. , Spiliotopoulos Anastasios , Owen Jonathan P. , Bishop Keith , Maddison Ben C. , Gough Kevin C. 
Published: February 2022

AbstractPhage display technology utilises peptide and antibody libraries with very high diversities to select ligands with specific binding properties. The production of such libraries can be labour intensive and technically challenging and whilst there are commercial sources of libraries, the exploitation of the resulting binders is constrained by ownership of the libraries. Here, a peptide library of ~ 1 × 109 variants for display on gene VIII was produced alongside three VHH antibody libraries with similar diversity, where 12mer, 16mer or 21mer CDR3s were introduced into the highly stable cAbBCII10 scaffold displayed on gene III. The cloning strategy used a simple whole-plasmid PCR method and type IIS restriction enzyme assembly that facilitate the seamless insertion of diversity into any suitable phage coat protein or antibody scaffold. This method reproducibly produced 1 × 109 variants from just 10 transformations and the four libraries had relatively low bias with 82 to 86% of all sequences present as single copies. The functionality of both peptide and antibody libraries were demonstrated by selection of ligands with specific binding properties by biopanning. The peptide library was used to epitope map a monoclonal antibody. The VHH libraries were pooled and used to select an antibody to recombinant human collagen type 1.
Psoas muscle size, possible sarcopenia and frailty, and long-term survival in elderly patients after isolated surgical aortic valve replacement for aortic stenosis
Authors: Kondo Yasuo , Suzuki Tomoaki , Enomoto Masahide , Takashima Noriyuki , Kinoshita Takeshi 
Published: February 2022

Abstract
Purpose
This study investigated the use of psoas muscle area index (PAI) as an indicator of mortality risk in relation to survival in elderly patients after isolated surgical aortic valve replacement (SAVR) for aortic valve stenosis (AS).

Methods
Between January 2005 and March 2015, 140 patients with AS, aged ≥ 70 years, and with preoperative abdominal computed tomography scans, underwent elective, primary, isolated SAVR. PAI showed the ratio of the psoas muscle cross-sectional area at the fourth lumbar vertebral level to body surface area, and PAI less than the gender-specific lowest 20th percentile we called “low PAI” for the purposes of this study. Patients were classified as low PAI (n = 29) or normal PAI (n = 111).

Results
The mean age in the low-PAI group was significantly older than in the normal-PAI group (81.0 vs. 77.3 years; p = 0.001). The mean follow-up was 4.25 years. The low-PAI group had a lower survival rate than the normal-PAI group at 1 year (89.7 ± 5.7% vs. 96.3 ± 1.8%), at 3 years (71.6 ± 9.3% vs. 91.5 ± 2.7%), and overall (53.0 ± 13.4% vs. 76.0 ± 5.6%; p = 0.039). The prognostic factors of mortality included low PAI (hazard ratio 2.95; 95% confidence interval 1.084–8.079; p = 0.034).

Conclusions
PAI was associated with reduced overall survival after isolated SAVR in elderly people. PAI measurement may help to predict patient risks.
STAT1/IFIT2 signaling pathway is involved in PD-L1-mediated epithelial-to-mesenchymal transition in human esophageal cancer
Authors: Chen J. , Liu Y. , Zhu Y. , Chen Y. , Feng J. , Jiang T. , Zheng X. , Chen L. , Jiang J. 
Published: February 2022

Abstract
Background
We have previously reported significant change of epithelial to mesenchymal transition (EMT) phenotype of Eca-109 cells upon PD-L1 operation, and the cytoplasmic domain of PD-L1 played an essential role in promoting EMT of esophageal cancer cells. However, the underlying mechanism of how PD-L1 regulated EMT in esophageal cancer remained unclear.

Methods
The overexpression and knockdown expression models of PD-L1 and IFIT2 were established by using lenti-virus transfection and RNAi method. Western blotting, qRT-PCR, CCK8 assay, transwell assay and wound healing assay were chosen to investigate their impact on the cells. The expression levels of IFIT2 and EMT markers in esophageal cancer tissues were examined by immunohistochemical staining. The rescue experiments were further applied to investigate the role of STAT1/IFIT2 signal pathway in the PD-L1-mediated EMT. Luciferase reporter assays were performed to examine the IFIT2 promoter activities upon knockdown expression of PD-L1 to identify the putative targeted region of IFIT2 promoter.

Results
The STAT1/IFIT2 signal pathway was activated when PD-L1 was knockdown in human esophageal cancer cells. Decreased IFIT2 expression significantly increased the cellular abilities of viability, invasion and migration by using RNAi method in human esophageal cancer cells. Decreased IFIT2 expression in esophageal cancer tissues significantly correlated with EMT status, and could be used as an independent prognostic predictor for the patients. Rescue experiments in PD-L1 knockdown cells further confirmed that STAT1/IFIT2 pathway was involved in the PD-L1 mediated EMT of esophageal cancer cells. Moreover, the luciferase reporter assay also confirmed that in esophageal cancer cells, the promoter region of IFIT2 (-3K~-1K) remains more active in PD-L1 knockdown expression cells compared with controls.

Conclusion
Our present work reveals a novel mechanism of how PD-L1 regulates EMT of cancer cells, namely STAT1/IFIT2 signal pathway is required in PD-L1 mediated EMT in human esophageal cancer.
Numerical analysis of subgrain formation during metal cutting and rolling based on the crystal plasticity theory
Authors: Nagashima Fumihisa , Nakagawa Yuki , Yoshino Masahiko 
Published: February 2022

AbstractThe grain refinement technology is important in improving the metallic material properties without the requirement of additional alloy elements. Previously, we developed an efficient method for producing ultrafine-grained steel strips using a combination of cutting and heat treatment. However, the effect of cutting on recrystallization was not apparent. The objective of this study is to investigate the effects of metal cutting on static recrystallization and outline its advantages in grain refinement using numerical simulations based on the crystal plasticity theory. Simulation results show that shear deformation in metal cutting activates more slip systems than plane strain compression via rolling, even when considering the same equivalent plastic strain. The geometrically necessary dislocations are assumed to accumulate in the crystal because many slip systems are activated in shear deformation and improve grain refinement via static recrystallization in the subsequent heat treatment. This result indicates that the deformation type plays an important role in the recrystallization process. Thus, cutting is more efficient than rolling for the production of ultrafine-grained steel.
Design of robust control for uncertain fuzzy quadruple-tank systems with time-varying delays
Authors: Naami Ghali , Ouahi Mohamed , Rabhi Abdelhamid , Tadeo Fernando , Tuan Viet Long Bui 
Published: February 2022

AbstractThe robust$$H_\infty$$H∞observer-based control design is addressed here for non-linear Takagi-Sugeno (T-S) fuzzy systems with time-varying delays, subject to uncertainties and external disturbances. This is motivated by the quadruple-tank with time delay control problem. The observer design methodology is based on constructing an appropriate Lyapunov–Krasovskii functional (LKF) for an augmented system formed from the original and the delayed states. The bilinear terms are transferred to the linear matrix inequalities, thanks to a change of variables which can be solved in one step. Furthermore, by employing the$$\mathcal {L}_2$$L2performance index, the adverse effects of persistent bounded disturbances is largely avoided. The proposed method has the advantage of relating the controller and Lyapunov function to both the original and delayed states. Then, the controller and observer gains are obtained simultaneously by solving these inequalities with off-the-shelf software (Yalmip/MATLAB toolbox). Finally, an application to a simulated quadruple-tank system with time delay is carried out to demonstrate the benefits of the proposed technique, showing a compromise between controller simplicity and robustness that outperforms previous approaches.
Meta-analysis of Supply Chain Disruption Research
Authors: Novoszel Lydia , Wakolbinger Tina 
Published: February 2022

AbstractThe purpose of this chapter is to provide insights into literature on supply chain disruption research with a specific focus on future research opportunities. A structured meta-literature review approach covering 93 literature reviews was chosen. Quantitative and qualitative content analysis and bibliographic network analysis are applied to highlight trends and research gaps. The meta-analysis shows the current and past academic discourse on supply chain disruptions. Furthermore, this research establishes a research framework and highlights future research opportunities. The research points to research topics that should be addressed in the future. The paper provides a holistic understanding of literature on supply chain disruptions in the commercial and humanitarian context.
The role of religion in female labor supply: evidence from two Muslim denominations
Authors: Akyol Pelin , Ökten Çağla 
Published: February 2022

AbstractThis paper investigates the association between religion and female labor market outcomes using new micro-level data on two distinct Muslim denominations in Turkey: Sunni and Alevi Muslims. We find a positive and significant association between being an Alevi Muslim and female labor force participation and employment, whereas there are no significant differences in male labor market outcomes between the two denominations. We provide evidence that Alevi Muslims have more gender-equal views regarding the role of women in the labor market and consider themselves as more modern. Both Sunnis and Alevis consider themselves as believers in religion (Islam). However, Sunnis are more likely to abide by the rules of religion. We argue that differences in views on gender roles and self-identity regarding modernity between the two denominations drive the results on female labor market outcomes.
They, the people. Italian Fascism and the ambivalences of corporative populism
Authors: Cerasi Laura 
Published: February 2022

AbstractThis paper argues that, in terms of their view of the ‘people’, leaderistic plebiscitarism and corporative organicism are two sides of the same coin, which resulted in aspirational fascist totalitarian democracy. The binary – and intrinsically ambiguous – view of the ‘people’ is examined first in the passive and indeterminate qualities attributed to the Italian population, then in the institutional device designed to lead it. The resulting twofold paradigm of corporative populism is reviewed with reference to the model put together and popularised by Giuseppe Bottai, which is presented in three different forms.