bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Droplet Manipulation on Ultrafast Lubricant Self‐Mediating Photothermal Slippery Surfaces
Authors: Zhan Haiyang , Xia Yuhang , Liu Yihe , Sun Haojie , Ge Wenna , Feng Shile , Liu Yahua 
Published: December 2022

AbstractDesigning intelligent slippery surfaces for droplet manipulation is critical for many applications from drug delivery to bio‐analysis, while is of great challenging in sustainability for inescapable wastage of lubricant layer. Herein, an ultrafast lubricant self‐mediating (self‐replenishing/‐absorbing) photothermal slippery surface is designed that achieves sustainable transport of droplet under the irradiation of near infrared light (NIL) even if the lubricant layer is wiped clean completely, as well as at other man‐made extreme conditions. The ultrafast lubricant self‐mediating performance is caused by synergistic effects of interconnection of porous structure and photothermal expansion of the material. When lubricant on surface is lost, photothermal expansion of material can quickly squeeze the lubricant inside the base to flow into and out of the interconnected porous structure to generate a fresh lubricant layer. Attractively, when the NIL is turned off, the rebuilt lubricant layer can be swiftly self‐absorbed into the porous to inhibit unnecessary wastage. Moreover, an arbitrary split of droplet in desired configurations can be achieved by controlling the NIL irradiating route. This sustainable droplet manipulation induced by ultrafast lubricant self‐mediating can be extensively applied in microfluidics and micro‐reactor settings.
The impact of early hepatitis B virus viral suppression on treatment response in entecavir‐treated hepatitis B e antigen‐positive chronic hepatitis B
Authors: Huang Yi‐Jie , Chang Chi‐Sen , Yeh Hong‐Zen , Yang Sheng‐Shun , Chang Chung‐Hsin 
Published: December 2022

AbstractTo investigate the impact of early HBV DNA suppression after receiving entecavir (ETV) on treatment response in hepatitis B e antigen (HBeAg) positive chronic hepatitis B (CHB) patients. A total of 140 baseline HBV DNA‐matched HBeAg‐positive patients receiving ETV were enrolled. Of those 70 patients achieved early virological response at week 24 (VR24 group) and the remaining 70 patients failed to achieve VR24 (non‐VR24 group). Factors of serological and virological outcomes were analyzed. Patients with pretherapy alanine aminotransferase (ALT) levels over five times upper limit of normal had a higher HBeAg seroclearance rate (P = .038). The VR24 group had the higher ratio of HBeAg seroclearance and maintained viral suppression within 96 and 144 weeks, respectively (53% and 75%, respectively). The cumulative rates of virological breakthrough (VBT) in the VR24 group and non‐VR24 group were 0% and 5.71%, 3.2% and 11.83%, 3.2% and 17.24%, 3.2% and 17.24%, and 3.2% and 21.84% from week 48 to 240, every 48 weeks, respectively (P = .006). In the multivariate analysis, undetectable HBV DNA and age at week 24 were associated with VBT (P = .02 and .006, respectively). Pretherapy ALT levels predicted a higher probability of HBeAg seroclearance. VR24 could be associated with HBeAg seroclearance and maintained viral suppression during therapy. Detectable HBV DNA at week 24 and older age could be predictive factors with an occurrence of VBT in HBeAg‐positive CHB patients treated with ETV.
Propagation Characteristics of Surface Plasmon Polaritons Near Anisotropic 2D Materials Sandwiched by Chiral Media
Authors: Zhao Rui , Liu Xingguang , Zhang Yingjie , Li Junqing 
Published: December 2022

AbstractA novel surface plasmonic waveguide structure composed of chiral medium and 2D material is proposed. The universal direction‐dependent dispersion relation is obtained, which covers the combinations between 2D materials with in‐plane isotropy or anisotropy and the surroundings with or without chirality. The tunability of the behavior of surface plasmon polaritons with the chirality of environment and the doping level are investigated. The averaging effect of chirality in both sides of 2D material is unveiled. Besides, the transverse spin of SPPs in the Chiral‐2D material structure is explored and the asymmetric distribution of the transverse spin depends mainly on the contribution from the magnetic spin instead of the electric spin. These features are advantageous for the manufacture of novel photonic devices and the development of sensors techniques for the chiral environment.
Thermoelectricity in a Quasiperiodic Lattice Beyond Nearest‐Neighbor Electron Hopping
Authors: Dey Moumita , Mukherjee Anwesha , Maiti Santanu K. 
Published: December 2022

AbstractA new route to obtain a large figure of merit (>1) is reported, for the first time, by considering a one‐dimensional quasiperiodic lattice where an electron can hop beyond usual nearest‐neighbor sites. A finite positional correlation is imposed among the constituent lattice sites, following the well‐known Aubry‐André‐Harper (AAH) form. In the presence of second‐neighbor hopping, the AAH lattice exhibits energy dependent mobility edge which plays the central role for efficient energy conversion. Employing a tight‐binding framework, all the thermoelectric quantities are computed based on the standard nonequilibrium Green's function formalism. The analysis can be utilized to investigate thermoelectric phenomena in similar kinds of other aperiodic systems possessing higher order electron hopping.
Transmission Reflection Integrated Programmable Metasurface for Real‐Time Beam Control and High Efficiency Transmission Polarization Conversion
Authors: Qin Zhe , Li Yongfeng , Wang He , Li Chenchen , Liu Chao , Zhu Zhibiao , Yuan Qi , Wang Jiafu , Qu Shaobo 
Published: December 2022

AbstractThe functional versatility and flexibility of multifunctional metasurfaces are of great significance for the application of electromagnetic (EM) metasurfaces in military stealth, holographic imaging, base station antennas, and other fields. Nevertheless, the functions of active programmable coding multifunctional metasurfaces are mostly reflective or transmissive, and the research on active multifunctional metasurfaces with transmission and reflection integration is still in its infancy. Here, a transmission reflection integrated active programmable coding metasurface is proposed to manipulate the transmission and reflection of different polarized electromagnetic waves independently in real time. As a proof of concept, a metasurface that can implement diverse programmable functionalities is designed. Numerical and experimental results indicate that the strategy has excellent performance in beam control and polarization conversion, which provides tremendous potential for extending highly integrated multifunctional devices.
Enhanced Charging in Common Environments Compared to Independent Environments for Two‐Level Systems
Authors: Xu Kai , Chen Jin‐Jun , Li Hong‐Guo , Zhu Hao , Zhu Han‐Jie , Liu Wu‐Ming 
Published: December 2022

AbstractThe charging process of a quantum battery (i.e., a two‐level system) is studied in two scenarios, that is, a quantum battery and a charger are coupled to the common reservoir environments or coupled to their respective independent environments. In the common reservoir scenario, it is shown that the optimal charging process can be realized by increasing the number of environments and setting the same coupling strength between battery‐reservoirs and charger‐reservoirs. In the independent reservoir scenario, however, it is shown that decreasing either the number of reservoir environments or the coupling strength would enhance the charging performance. These results demonstrate that the charging performance of quantum batteries can be significantly improved by constructing common environments. This may be of help to the realization of the quantum battery with optimal charging performance in multiple environments.
Interstitial‐Electron‐Induced Topological Molecular Crystals
Authors: Yu Tonghua , Arita Ryotaro , Hirayama Motoaki 
Published: December 2022

AbstractTopological phases are usually unreachable in molecular solids, which are characterized by weakly dispersed energy bands with a large gap, in contrast to topological materials. In this work, however, it is proposed that nontrivial electronic topology may ubiquitously emerge in a class of molecular crystals that contain interstitial electronic states, the bands of which are prone to be inverted with those of molecular orbitals. Guidelines are provided to hunt for such interstitial‐electron‐induced topological molecular crystals, especially in the topological insulating state. They exhibit a variety of exceptional qualities, as brought about by the intrinsic interplay of molecular crystals, interstitial electrons, and topological nature: 1) They may host cleavable surfaces along multiple orientations, with pronounced topological boundary states free from dangling bonds. 2) Strong response to moderate mechanical perturbations, whereby topological phase transition would occur under relatively low pressure. 3) Inherent high‐efficiency thermoelectricity as jointly contributed by the non‐parabolic band structure (therewith high thermopower), highly mobile interstitial electrons (high electrical conductivity), and soft phonons (small lattice thermal conductivity). 4) Ultralow work function owing to the active interstitial electrons. First‐principles calculations are utilized to demonstrate these properties with the representative candidate K4Ba2[SnBi4]. This work suggests a pathway of realizing topological phases in bulk molecular systems, which may advance the interdisciplinary research between topological and molecular materials.
Drug‐coated balloon treatment of complex femoropopliteal disease yields favorable and durable outcomes at 5 years
Authors: Winscott John G. , Hillegass William B. 
Published: December 2022

Key Points
Randomized clinical trials have previously demonstrated drug‐coated balloon (DCB) treatment of femoropopliteal disease reduces the odds of clinically driven target lesion revascularization (CD‐TLR) by 60%–70% at 2–3 years compared to balloon angioplasty alone.
The single‐arm IN.PACT Global Study demonstrates clinical outcomes observed at 2 years tend to remain durably stable through 5 years of follow‐up.
Approximately three‐quarters of patients undergoing DCB treatment of relatively complex femoropopliteal disease had freedom from CD‐TLR at 5 years.
Dimension of heterogeneous network architecture formed in emulsion cross‐linking copolymerization
Authors: Tobita Hidetaka 
Published: December 2022

AbstractThe mean‐square radius of gyration Rg2 and the graph diameter D of highly heterogeneous network polymers formed in emulsion vinyl/divinyl copolymerization are investigated to find a linear relationship, Rg2 = a D. The proportionality coefficient, a, is dominated by the cycle (circuit) rank, kc, or the number of intramolecular cross‐links. The magnitude of a is slightly larger than that for the random cross‐linked network polymers, but the functional form of a (kc) is simply proportional to that for the random networks proposed earlier. This relationship makes it possible to determine Rg2 based on D and kc, enabling quick estimation of Rg2 for large network polymers. It is found that the contraction factor g of the present heterogeneous network polymer is larger than that for the homogeneous networks formed through random cross‐linking of polymer chains. The ratio of these two contraction factors is kept constant, irrespective of the magnitude of kc.
Evaluating the impact of early identification of asymptomatic brain metastases in metastatic renal cell carcinoma
Authors: Parmar Ambica , Ghosh Sunita , Sahgal Arjun , Lalani Aly‐Khan A. , Hansen Aaron R. , Reaume M. Neil , Wood Lori , Basappa Naveen S. , Heng Daniel Y. C. , Graham Jeffrey , Kollmannsberger Christian , Soulières Denis , Breau Rodney H. , Tanguay Simon , Kapoor Anil , Pouliot Frédéric , Bjarnason Georg A. 
Published: December 2022

AbstractBackgroundBrain metastases (BM) in metastatic renal cell carcinoma (mRCC) have been reported to be present in up to 25% of patients diagnosed with mRCC. There is limited published literature evaluating the role of routine intra‐cranial imaging for the screening of asymptomatic BM in mRCC.AimsTo evaluate the potential utility of routine intra‐cranial imaging, a retrospective cohort study was conducted to characterize the outcomes of mRCC patients who presented with asymptomatic BM, as compared to symptomatic BM.Methods and ResultsThe Canadian Kidney Cancer Information System (CKCis) database was used to identify mRCC patients diagnosed with BM. This cohort was divided into two groups based on the presence or absence of BM symptoms. Details regarding patient demographics, disease characteristics, systemic treatments, BM characteristics and survival outcomes were extracted. Statistical analysis was through chi‐square tests, analysis of variance, and Kaplan–Meier method to characterize survival outcomes. A p‐value of <0.05 was considered statistically significant for all analyses. A total of 267 mRCC patients with BM were identified of which 106 (40%) presented with asymptomatic disease. The majority of patients presented with multiple (i.e., >1) BM (75%) with no significant differences noted in number of BM or BM‐directed therapy received in symptomatic, as compared to asymptomatic BM patients. Median [95% confidence interval (CI)] overall survival (OS) from mRCC diagnosis was 42 months (95% CI: 32–62) for patients with asymptomatic BM, and 39 months (95% CI: 29–48) with symptomatic BM (p = 0.10). OS from time of BM diagnosis was 28 months (95% CI: 18–42) for the asymptomatic BM group, as compared to 13 months (95% CI: 10–21) in the symptomatic BM group (p = 0.04).ConclusionsGiven a substantial proportion of patients may present with asymptomatic BM, limiting intra‐cranial imaging to patients with symptomatic BM, may be associated with a missed opportunity for timely diagnosis and treatment. The utility of routine intra‐cranial imaging in patients with renal cell carcinoma, warrants further prospective evaluation.
FIP1L1‐PDGFRA fusion gene in T‐lymphoblastic lymphoma: A case report
Authors: Ali Salhah , Al‐Qattan Yasmine , Awny Walaa , Hamadah Abdulaziz , Pinto Karen , AlShemmari Salem 
Published: December 2022

AbstractBackgroundT‐lymphoblastic lymphoma (T‐LBL) is an aggressive malignancy of T‐lymphoid precursors, rarely co‐occurring with myeloid/lymphoid neoplasms with eosinophilia (M/LNs‐Eo), with consequent rearrangement of tyrosine kinase (TK)‐related genes. The FIP1L1‐PDGFRA fusion gene is the most frequent molecular abnormality seen in eosinophilia‐associated myeloproliferative disorders, but is also present in acute myeloid leukemia (AML), T‐lymphoblastic leukemia/lymphoma (TLL), or both simultaneously. T‐LBL mainly affects children and young adults, involving lymph node, bone marrow, and thymus. It represents about 85% of all immature lymphoblastic lymphomas, whereas immature B‐cell lymphomas comprise approximately 15% of all cases of LBL.CaseIn this case report, we present an example of T cell lymphoblastic lymphoma with coexistent eosinophelia, treated successfully with a tyrosine‐kinase inhibitor (TKI).ConclusionFIP1L1‐PDGFRA‐positive T‐LBL and myeloproliferative disorders have excellent response to low‐dose treatment with (TKI) imatinib. Most patients achieve rapid and complete hematologic and molecular remission within weeks.
Human Embryonic Stem Cells as a Model for Hematopoietic Stem Cell Differentiation and Viral Infection
Authors: Crawford Lindsey B. 
Published: December 2022

AbstractPluripotent human embryonic stem cell (hESC) lines are a valuable in vitro tool to differentiate specific cell lineages, including cells from all three germ layers, i.e., neuronal cells, myocytes, and hematopoietic cells, including progenitors (described here), lymphoid cells, and myeloid cells. However, dramatically different cell subtypes and functional properties of specific cells can arise depending on the differentiation technique used. We previously optimized hematopoietic stem cell differentiation from two different NIH‐approved hESC lines to generate CD34+ hematopoietic progenitor cells (HPCs). Infection of these HPCs with a common herpesvirus (human cytomegalovirus) results in maintenance of viral latency, capability of viral reactivation, recapitulation of viral mutant phenotypes, and virus‐induced myelosuppression of hematopoietic differentiation. However, different HPC subpopulations support different viral latency and reactivation phenotypes, and different hESC‐to‐HPC differentiation methods alter the ratio of stem cell subsets. In addition, differences in differentiation methods are dependent on both protocol/reagents and user techniques. Here, we report a simplified and optimized method to generate large numbers of CD34+ HPCs with consistent phenotypes and demonstrate a comparison of several common methods that can be used to control the ratio of available HPC subpopulations. A key aspect of this approach is that we achieve consistency in differentiation across users in different laboratories and, importantly, among newly trained individuals. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Maintenance of human embryonic stem cells (hESCs)Basic Protocol 2: Differentiation of hESCs to hematopoietic progenitor cells (HPCs)Basic Protocol 3: Downstream functional differentiation of hESC‐derived HPCs to mature lineagesSupport Protocol 1: Freezing and testing frozen batches of hESCsSupport Protocol 2: Counting hESCsSupport Protocol 3: Phenotyping by flow cytometry
Influence of drought stress and foliar application of chitosan on nutrient accumulation and phenolic composition of Thymus daenensis Celak
Authors: Bistgani Zohreh Emami , Hashemi Masoud , Akbari Parisa , Mumivand Hassan 
Published: December 2022

AbstractChanges in climate have intensified the drought in semi‐arid regions. A shift toward cultivation of low‐input crops, including high‐value medicinal and herbal plants seems a more sustainable alternative strategy. A 2‐year field study was conducted to investigate the influence of drought stress and chitosan on nutrient density and phenolic compounds of thyme. Treatments consisted of a factorial combination of three irrigation and three chitosan rates. Irrigation treatments consisted of keeping experimental plots at field capacity (no stress), irrigation when plots reached 50% of field capacity (mild stress), and irrigation when plots reached 25% of field capacity (severe stress). Chitosan rates were 0, 200, and 400 μL L−1, while K+, and to some degree Ca+2, accumulation increased by drought, N, P, and all micronutrients (Mn2+, Zn2+, Cu2+, and Fe2+) decreased steadily as drought stress intensified. Drought stress reduced N and P by 23%–19% and 35%–23%, respectively, over the 2 years. Application of chitosan enhanced the accumulation of macro and micronutrients. Drought stress resulted in alterations in phenolic composition. In mature plants, almost all phenolic compounds, except thymol, increased as drought stress intensified. Cinnamic acid and rosmarinic contents, as the two major identified compounds, increased by 31% and 45%, respectively, under severe drought. Similar to drought, chitosan elicitation was more effective in elevating phenolic compounds in mature plants. The response of thyme to chitosan was independent of soil moisture availability. The results indicated that application of 400 μL−1 chitosan improved nutrient density and dry matter while significantly saved irrigation water.
Evaluation of blood‐based, extracellular vesicles as biomarkers for aging‐related TDP‐43 pathology
Authors: Winston Charisse N. , Sukreet Sonal , Lynch Haley , Lee Virginia M.‐Y. , Wilcock Donna M. , Nelson Peter T. , Rissman Robert A. 
Published: December 2022

AbstractIntroductionLimbic predominant age related TDP‐43 encephalopathy neuropathological change (LATE‐NC) is a recently characterized brain disease that mimics Alzheimer's disease (AD) clinically. To date, LATE‐NC is difficult to diagnose antemortem using clinical information or biomarkers. Recent studies suggest concentrations of extracellular vesicle (EVs) protein cargo derived from neuronal and glial cells may serve as useful diagnostic biomarkers for AD and other neurodegenerative diseases.MethodsTDP‐43 was evaluated in neuronal (NDEVs), astrocyte (ADEVs), and microglial derived extracellular vesicles (MDEVs). EV preparations were isolated from the plasma of research subjects with autopsy‐confirmed diagnoses, including many with LATE (n = 22). Quantified TDP‐43 concentrations were compared to the cohort that included healthy controls, mild cognitively impairment (MCI), and AD dementia with diagnoses other than LATE‐NC (n = 42).ResultsTDP‐43 was significantly elevated in plasma ADEVs derived from autopsy confirmed LATE‐NC subjects, with or without comorbid AD pathology. Measurable levels of TDP‐43 were also detected in EV‐depleted plasma; however, TDP‐43 levels were not significantly different between persons with and without eventual autopsy confirmed LATE‐NC. No correlation was observed between EV TDP‐43 levels with cognition‐based variables, sex, and APOE carrier status.DiscussionBlood‐based EVs, specifically measuring TDP‐43 accumulation in ADEVs, may serve as a potential diagnostic tool to rapidly identify subjects who are currently living with LATE‐NC.
Comparative study of the effect of different temperatures on bovine bone used for bone repair of critical calvaria defects in rats
Authors: Egas Lais Sara , Matsumoto Mariza Akemi , Hadad Henrique , Tonini Karen Rawen , de Weert Daniela Atili Brandini , Perri de Carvalho Paulo Sérgio , Ponzoni Daniela 
Published: December 2022

AbstractTo evaluate the osteoconductive potential of inorganic biomaterials of bovine origin submitted to different temperatures in the bone repair of critical defects in rat calvaria. Forty‐eight rats were divided into four groups according to the material used to fill the defect: control group (GC), the defect was filled only with blood clot (n = 12); GBO, defect filled with Bio‐Oss®, deproteinzed at 300°C (n = 12); GOX, defect filled with Inorganic GenOx®, deproteinzed from 850 to 1200°C (n = 12) and G700, defect filled with Inorganic GenOx 700, deproteinzed at 700°C (n = 12). In each animal's calvaria, a trephine bur with 5 mm internal diameter was used to produce a 6 mm‐diameter central defect. Gen Derm® resorbable bovine membrane was superimposed over all defects. Subsequently, animals were euthanized at 30 and 60 days after surgery. The pieces were sent for histological and histometric analysis to evaluate the following variables: bone neoformation, presence of biomaterial, mononuclear and polymorphonuclear leukocytes, presence of other tissues (granulation and medullary) and maturation of collagen fibers. The most representative group for bone neoformation was GC. At 30 days, there was a higher mean of mature bone tissue (75.8). At 60 days, there was no statistical difference between the GC (64.9), GBO (32.9), GOX (45.3), and G700 (26.6) groups. GBO presented the highest amount of biomaterial after 30 days (115.9) and 60 days (118.5). All bovine biomaterials were biocompatible and osteoconductive. GOX promoted the best bone repair of the studied materials.