bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetraspanin CD63 reduces the progression and metastasis of head and neck squamous cell carcinoma via KRT1-mediated cell cycle arrest
Authors: Huang Qiang , Shen Yu-Jie , Hsueh Chi-Yao , Zhang Yi-Fan , Guo Yang , Yuan Xiao-Hui , Hu Chun-Yan , Li Jiao-Yu , Tao Lei , Gong Hong-Li , Zhang Ming , Zhou Liang 
Published: May 2022

Abstract
Background: Though metastasis is the leading cause of death in patients with head and neck squamous cell carcinoma (HNSCC), fundamental questions about the mechanisms that enable or inhibit metastasis remain unanswered. CD63, a tetraspanin family member, has been linked to tumor progression and metastasis. However, few studies have examined the role of CD63 in HNSCC. Methods: We discovered CD63 expression in paired HNSCC tissue by tissue microarray. Cell phenotype experiments and lung metastasis mouse model were adopted to investigate the effect of CD63 on tumour metastasis in vitro and vivo. The molecular mechanism was investigated by mass spectrometry, Co-IP, immunofluorescence analysis and molecular docking. Results: CD63 expression was abnormally decreased in HNSCC tissue compared to adjacent tissue, and that this was linked to prognosis. Overexpression of CD63 inhibited the progression and metastasis of HNSCC cells. KRT1 could be a direct interacting partner of CD63. CD63 reduces HNSCC progression via KRT1-mediated cell cycle arrest. Both CD63 and KRT1 expression was significantly decreased in metastatic tissue compared with primary tumor tissue. Conclusions: We reveal a previously unrecognized role of CD63 in HNSCC cells. Our findings contribute to defining an important mechanism of HNSCC progression and metastasis.
Increased Sample Size Proved More Insights for the Population Structure of Mediterranean Loggerhead Sea Turtles
Authors: Kaska Arzu , Koç Gizem , Sözbilen Dogan , Diryaq Salih , Glidan Ashraf , Elsowayeb Abd Alati , Saied Almokhtar , Margaritoulis Dimitris , Theodorou Panagiota , Rees Alan F. , Snape Robin , Broderick Annette , Godley Brendan , Beton Damla , Ozkan Meryem , Jr Imed , Ismail Manel Ben , Hmida Ahmed Ben , Badreddine Ali , Sacdanaku Enerit , Rae Vicky , Abdelwarith Mohamed Said , Naguib Nahla , Nakhla Lobna Ben , Limam Atef , Abderrahim Marwan , Sémelin Julien , Kaska Yakup 
Published: May 2022

Abstract
The loggerhead sea turtle (Caretta caretta), has the broadest distribution among sea turtle species in the Mediterranean and requires regional and international collaborations in addition to local efforts to better inform conservation actions. Molecular techniques are powerful tools to assess population dynamics at large scales, especially by determining the connectivity among different nesting and foraging sites, and genetic diversity. In this study, a large sample was collected synchronously in the nesting areas located in the north, south and east of the Mediterranean. Recently described nesting sites from Albania and other nesting sites represented by lower sample size were also included in order to fully assess the genetic composition of the region’s rookeries. Samples from 710 individuals were collected and the longer (815 bp) mtDNA D-loop fragment of these samples was amplified. We recorded 15 haplotypes, three of which were novel. In addition, our results show that some haplotypes, considered of Atlantic origin, have a wider dispersal in the Mediterranean than previously thought, albeit with low levels of representation. Our results, which also contribute to determining the likely origin of haplotypes that were previously known only from foraging sites, highlight the utility of broad-scale sampling, with increased sample number and longer mtDNA sequence to determine genetic diversity and connectivity. This study also demonstrates that it is important to continue to monitor the contribution of Atlantic origin haplotypes to the Mediterranean population, and the resident Mediterranean population, which is expected to expand its geographical range for reproduction with the effect of climate change and climate change in the long term. This work is important for, among other things, mixed stock analyses (MSA) that seek to localize the origin of stranded or accidentally caught sea turtles or those purposefully obtained from foraging sites to better understand the migratory distribution for conservation purposes.
Long term positional stability of the Argus II Retinal Prosthesis epiretinal implant
Authors: Ghani Nimra , Bansal Jahnvi , Naidu Abhishek , Chaudhary Khurram M. 
Published: May 2022

Abstract
BackgroundThe Argus II Retinal Prosthesis System (Second Sight Medical Products, Sylmar, California) is an epiretinal prosthesis that serves to provide useful vision to people who are affected by retinal degenerative diseases such as retinitis pigmentosa (RP). The purpose of this study was to analyze postoperative movement of the electrode array.MethodsFive patients diagnosed with profound retinal dystrophy who have undergone implantation of retinal prosthesis at Stony Brook University Hospital. Fundoscopy was performed at postoperative month 1 (M1), month 3 (M3), month 6 (M6), month 12 (M12), and month 24 (M24) visits. Fundoscopy was extracted and analyzed via NIH ImageJ. Data analysis was completed using IBM SPSS. Various lengths and angles were measured each postoperative month using ImageJ.ResultsThere was no significant change in distance between the optic disc and the surgical handle (length AB) over the two-year span (F = 0.196, p = 0.705). There was a significant change in distance of length AB overtime between patients between M3 and M6 (p = 0.025). A repeated measures ANOVA revealed that there was statistically significant change of the optic disc-tack-surgical handle angle (𝛾) (M1 to M24) (F = 3.527, p = 0.030). There was no significant change in angle 𝜟 (the angle to the horizontal of the image), angle 𝜶 (tack-optic disc-surgical handle), and angle 𝜷 (optic-disc-surgical handle-tack).ConclusionOur results demonstrate that there may be postoperative movement of the retinal prosthesis over time, as a statistically significant downward rotation is reported over the two years span. It is important, moving forward, to further study this movement and to take into consideration such movement when designing retinal implants.
Evaluation of PASI Before and After Combined Treatment in Mild to Moderate Psoriasis
Authors: Benites Elizabeth , Carrillo Esmeralda , Heras Martha , Moreno Franklin , Cornejo Carlos 
Published: May 2022

Abstract
Background. -
Plaque psoriasis is a disease of immunological origin that damages the skin, mucous membranes. Biological therapies combined with systemic medications are effective in treating plaque psoriasis. Our objective was to evaluate the treatment of Etanercept with methotrexate and to verify its response with the PASI index in its initial and control phase.
Methodology. -
The Universe of patient treated at the Military Hospital in Guayaquil was 2.620 corresponding from January until July 2020; the selected sample according to the inclusion criteria was 94 patients with plaque psoriasis. The method was retrospective, observational, descriptive, cross-sectional, correlational differential analytical.
Result. -
In this study, the prevalence was 3.58%, The BMI index was 28.13 corresponding to overweight and obesity. The PASI index in the initial stage before treatment showed 10.8% and in the control phase, it fell to 2.99%, showing a decrease in lesions and good improvement to the combined treatment. In Student´s T, the combination of Etanercept with Methotrexate was compared with de evolution of PASI index, in the initial and control phases, presenting a value lower than 0.001 < P = 0.05, this response being very significant
Discussion. -
In our study, the combination of Etanercept with Methotrexate has a favorable this disease response in reducing this disease. It´s expected that, in Ecuador, the Health Authorities would implement the Biologics for the treatment of plaque psoriasis and including them in the basic list of medicines of the Public Health Ministry.
A Conceptual Proposal for Ankara's Historical Heritage: Atatürk Forest Farm
Authors: Didem Dizdaroglu 
Published: May 2022

Abstract
Context
Established as green infrastructure for the creation of a systematic agricultural structure for the first time in the history of the Republic, Atatürk Forest Farm (AOÇ) is a cultural heritage. AOÇ has the capacity to become a new food planning and management center as well as an urban open space for citizens and to reconstitute Ankara as a self-sufficient city in the 21st century.
Objectives
This study aims to preserve the AOÇ lands for reevaluating them with an ecological approach in terms of today’s conditions. Regarding the AOÇ’s founding purposes, this study offers a conceptual proposal for reclaiming and reorganizing the Farm.
Methods
The methodology involves literature reviews, examination of AOÇ’s historical development process and planning decisions, site analysis, and development of a conceptual proposal for the designated study area.
Results
Urban agriculture (UA) has the potential to modify existing urban sites into new forms of green spaces offering an alternative land use integrating multiple uses. This study proposes conceptually some opportunities for developing AOÇ, which has the potential to become a productive and ecologically sustainable urban green space with offering various UA benefits.
Conclusions
AOÇ has a significant place and meaning in the collective memory of the Turkish nation and acts as a bridge that carries the past to the future. The farm should be reintroduced to the urban life with new ecological, recreational, and cultural functions by preserving its mission to be an example of a production that fulfills the city’s agricultural and nutritional needs.
Conservation at the edge: connectivity and opportunities from non-protected coral reefs close to a national park in the Colombian Caribbean
Authors: Rodríguez Laura , Acosta Alberto , González-Zapata Fanny L. , Gómez-Corrales Matías , Marrugo Milena , Alvarado-Ch Elvira M. , Dueñas Luisa F. , Andrade Julio , Gutierrez-Cala Lina , Sánchez Juan Armando 
Published: May 2022

Abstract
Confronting a sustained coral reef conservation crisis, we need new opportunities to rethink how to protect areas successfully and efficiently in the face of a changing world. We studied the benthic community, including foraminifera, fish community, and genetic connectivity (SSRs and SNPs) of main reef-building coral, Orbicella faveolata and Agaricia undata coral, along a Non-Protected Area (NPA) reef tract in Barú peninsula, including some isolated banks, near Cartagena and the National Natural Park Corales del Rosario y San Bernando (NNP CRySB), Colombia. The fringing reef track studied is homogeneous in benthic components, including algae, corals, sponges, and foraminifera between all the sites studied. Many reef sites sustain between 42.8% and 53% coral cover, which are among the highest recorded in this region, even higher than values in the nearby NNP. A total of 82 fish species were found, and the Foram Index-FI varies between 2 and 2.5, showing environmental conditions marginal for reef growth. The Barú NPA reef system can be considered spatial refugia under climate change and Anthropocene conditions, including resilient reefs at the mouth of Cartagena Bay (Magdalena River), a place of increased stressing factors. The admixture between NPA and NNP populations, the high coral cover in the NPA, the fish density and composition, the uniqueness of the diapiric banks, and the disturbance resistance are major arguments to protect this reef tract. We suggest designing a co-management scheme to ensure species connectivity, avoid further degradation, and involve different stakeholders.
Penyataan Diri Allah di Tengah Kerapuhan Dunia: Pesan Teologis tentang Inkarnasi Allah dalam Tradisi Teologis Yohanes
Authors: Rachmadi Simon 
Published: May 2022

Abstract This article describes a theological idea about the presence of God among God’s people. The presence of God takes the form of becoming “flesh” (incarnation), as depicted by the Johannine tradition in the Gospel of John, the First Letter of John, and the Book of Revelation. By becoming “flesh” God wholly participates in the vulnerability and precariousness of the human “flesh”: pointing to the very nature of humanity. This articlelocates the divine incarnation within the daily life of human beings in the “flesh”. Using the method of simple Bible reading, with a limited theoretical approach, this article suggests a hermeneutical message of the Johannine tradition. Since the Word has become “flesh,” the divine realm could always be found in the vulnerability of the world. As a result, despitesuff ering (theodicy) remains a mystery, the experience of vulnerability — through critical, persistent, and grateful faith — is potentially worthy of accommodating the divine presence.
Abstrak Artikel ini mendeskripsikan suatu visi teologis tentang Allah yang setia menyertai umat-Nya. Kesetiaan menyertai umat-Nya itu terwujud dengan cara men-“daging” (berinkarnasi), sebagaimana terlukis di dalam tradisi Rasul Yohanes: yaitu di dalam Injil Yohanes, Surat 1 Yohanes, dan Kitab Wahyu. Cara men-“daging” itu membuat Allah senantiasa terlibat dalam aspek-aspek kerapuhan dan kehinaan kodrati “daging” manusia. Pertanyaannya, di manakah keterlibatan ilahi itu ditemukan di dalam realitas insani sehari-hari yang selalu bersalutkan aneka kerapuhan kodrati? Dengan metode pembacaan Alkitab sederhana,dengan pendekatan teoretis tafsir yang terbatas, artikel ini berusaha mendekati pertanyaan tersebut dengan memeriksa pesan hermeneutis dari tradisi Yohanes. Karena Sang Sabda menjadi “daging”, maka Allah bersemayam di dalam kerapuhan dunia. Akibatnya, meskipun misteri penderitaan (theodicy) tidak akan pernah dapat dijelaskan oleh manusia secara lengkap, pengalaman derita itu — via iman yang kritis, tabah, dan penuh syukur — selalu berpeluang untuk diolah menjadi wadah perjumpaan ilahi.
Assessment of the risks of changes in brachiocephalic vessels according to ultrasound examination of patients with obstructive sleep apnea
Authors: Rubina S. S. , Yusufov A. A. , Makarova I. I. , Tsvetkova N. V. , Larina O. S. 
Published: May 2022

Introduction. In the medical literature, there is not enough work on the impact of obstructive sleep apnea (OSA) on the development of atherosclerosis of the brachiocephalic arteries and venous dysgemenia. For the purpose of early diagnosis of vascular complications, further study of extracranial vessels in patients with OSA is necessary.Aim. To study the chances of changes in brachiocephalic vessels by ultrasound examination in patients with obstructive sleep apnea.Materials and methods. A survey was carried out of 88 patients. The results of anthropompetry, polysomnography and ultrasound examination of brachiocephalic vessels were evaluated.Results and discussion. New data were obtained on the severity of macroangiopathy, an increase in the peak systolic blood flow velocity in the internal jugular veins, and an increase in the diameters of the vertebral veins in patients with sleep apnea. It was also found that in patients with OSA, the chances of having a wide diameter of the common carotid artery (CCA) on both sides and the internal carotid artery on the left are more than 3 times higher, the probability of thickening of the intima-media complex in the area of the CCA and its bifurcation is more than on the left 3.5 times and the chances of macroangiopathy are 3 times higher in comparison with the examined patients without apnea.Conclusion. Timely assessment of the entire spectrum of pathological changes in the brachiocephalic vessels in patients with OSA will make it possible to diagnose early signs of atherosclerotic lesions of the arteries, venous dysfunction at the extracranial level.
Real possibilities of treatment of patients with allergic rhinitis
Authors: Svistushkin V. M. , Nikiforova G. N. , Levina L. А. , Zolotova A. V. , Shevchik E. A. 
Published: May 2022

Allergic rhinitis occupies a special place among diseases of the upper respiratory tract. Every year the urgency of the problem increases due to the annual increase in the incidence among all age groups of the population. Allergic diseases are often associated with other respiratory diseases or cause them, which requires early diagnosis and selection of competent therapy. Allergic reactions can range from seasonal allergens, such as tree or weed pollen, to year-round irritants, such as dust and pet dander. Currently, the pathogenesis of allergic rhinitis is being actively studied. There is still debate about the most accurate classification of allergic rhinitis, reflecting all its aspects, such as the time of onset and duration of symptoms, their impact on patients’ lives. This is necessary to find the best methods of treatment with maximum efficiency. The main clinical manifestations of allergic rhinitis are nasal itching, sneezing, swelling of the nasal mucosa and rhinorrhea. Often, to relieve symptoms, patients are forced to take many drugs for a long time, which has a significant impact on their quality of life. All over the world, new ways are being developed to optimize the treatment of this group of patients, among which combinations of several drugs used to treat allergic rhinitis, which meet all safety and efficacy requirements. The most commonly used and most effective combinations of drugs are combinations of intranasal glucocorticosteroids with topical histamine H1 receptor antagonists, as well as leukotriene receptor blockers with oral antihistamines.
Study on ground vibration characteristics induced by liquid CO2 blasting technique in bench excavation
Authors: Ruan Renyou , Pan Zhenxue , Wang Xingzhou , Zhan Wangmei 
Published: May 2022

The liquid CO2 phase change fracturing technique has been widely applied in rock engineering for a long time. However, the ground vibration characteristics in bench excavation have not been well demonstrated. In this study, the particle velocities, main frequencies, and displacements of rock induced by liquid CO2 blasting are investigated based on field tests and numerical simulations. Firstly, three field tests of bench excavation using DM83-1.4 type liquid CO2 storage tube were implemented in a specific highway slope project, in which the TC-4850 N vibration monitors were installed at horizontal distances of 4.2 m, 10.6 m, 20.3 m and 32.2 m from the detonation source to detect the rock vibration velocity and frequency. Subsequently, by employing the dynamic finite element program LS-DYNA, a three-dimensional numerical model was established, and then the particle velocities and displacements were analyzed and discussed. The research results indicate that the peak particle velocity (PPV) decays with distance in an exponential pattern, that is, the PPV decays rapidly in the near zone of the blasting source, and it decays more slowly in the far zone. At the position of 20.3 m in the horizontal distance and 15.8 m in elevation, an elevation amplification effect appears with an amplification factor of 1.12. Moreover, the vibration frequency generated by the liquid CO2 phase change fracturing technique is in the range of 0-80 Hz, which is much smaller than that induced by explosive blasting. The main frequency in the near-field of the blasting source is dominated by the radial frequency (Fr), while the vertical frequency (Fv) is dominant in the far-field. The attenuation law of displacement is generally consistent with the vibration velocity, and the difference between radial and tangential displacement increases gradually with distance.
Towards a virtual water currency for industrial products using blockchain technology
Authors: Angara Jayasri S. V. , Saripalle Ravi S. 
Published: May 2022

AbstractTracking unseen water in products (Embedded Virtual Water) has generated great interest in the scientific community. This water transfers between geographies via suppliers, manufacturers, distributors, retailers and customers in multiple phases. However, the Virtual Water Trading System lacks proper accounting standards, established protocols and processes in the context of product manufacturing. Therefore, there is a need to establish a technology platform to handle the complex virtual water international trade. Such a platform should uphold transparency and create ‘water consciousness’ and awareness among companies and consumers. The concept of a virtual water currency and blockchain technology platform together can manage these processes. Blockchain helps in setting up secure, verifiable, scalable and traceable systems. Blockchain manages the audit and contract management processes with ease. Virtual water currency is critical to advocate sustainability. The objective of this paper is to establish the key linkages between virtual water and usage of blockchain. A systematic literature survey was conducted on 16 journal repositories (153 journal papers) of IWA Publishing to establish virtual water linkages and five journal databases (IEEE Xplore, Sciencedirect, ACM Digital Library, Springer Link and Wiley Online Library covering 5026 journal papers) for blockchain and water management linkages. This study proposes to introduce virtual water currency and set up an International Virtual Water Trading System using blockchain. The proposed platform seamlessly integrates the quality, cost and sustainability of industrial products and their sub-components.
MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers
Authors: Du Zhuoying , Tan Fangshun , Chen Jinlan , Wang Bei , Liu Yuling , Zhao Fangnan , Wu Yinxin , Yuan Chengfu 
Published: May 2022

Background:
As a member of long non-coding RNAs (lncRNAs), maternally expressed gene 8
(MEG8) has been found involving in the progression of a variety of cancers and playing a regulatory role.
Therefore, MEG8 may turn into a new therapeutic target for cancer in the future. The purpose of this review is
to illustrate the molecular mechanism and physiological function of MEG8 in various cancers.

Methods:
We retrieved and analyzed related articles about MEG8, lncRNAs, and cancers, and then summarize
the pathophysiological mechanisms of MEG8 in cancer development.

Results:
LncRNA MEG8 participates in various cancers progression, thus influencing the proliferation, migration,
and invasion of cancers. However, the expression of MEG8 is abnormally upregulated in non-small cell
lung cancer (NSCLC), pancreatic cancer (PC), liver cancer (HCC), pituitary adenoma (PA) and hemangioma
(HA), and inhibited in colorectal cancer (CRC), ovarian cancer (OC) and giant cell tumor (GCT), suggesting its
clinical value in cancer therapy.

Conclusions:
LncRNA MEG8 is expected to be a new therapeutic target or biomarker for a wide range of cancers
in the future.