bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of simultaneous treatment of gamma irradiation and Bacillus thuringiensis on cotton leaf worm Spodoptera littoralis (Boisd.) (Noctuidae: Lepidoptera)
Authors: Sayed Waheed A. A. , Hassan Reda Sayed , Sileem Thanaa Mohamed 
Published: August 2022

Abstract
Background
The two biological control methods, inherited sterility technique (IST) and Bacillus thuringiensis (Bt), are considered as the two promising methods for lepidopteran pest management. Simultaneous treatment with both techniques was assessed against the cotton leaf worm, Spodoptera littoralis (Boisd.) (Noctuidae: Lepidoptera) compared to individual treatment for developing the lepidopteran management program.

Results
Pupation and adult emergence were significantly lower in simultaneous treatment than irradiated insects individually. Larval mortality test estimated a LC50 of 1.6 × 104 IU/mg (Bt), in which decreased to 1.5 × 104 IU/mg (Bt and 75 Gy), and 7.7 × 103 IU/mg (Bt and 125 Gy). Insect survival was prolonged for both individual and simultaneous treatments. The ratio of males was 3.5-fold to females in 1.5 × 104 IU/mg and 75 Gy, while threefold of males to females was recorded in the treatments of 3.75 × 103 IU/mg and 75 Gy, 7.5 × 103 IU/mg and 75 Gy, 7.5 × 103 IU/mg and 125 Gy and 1.5 × 104 IU/mg and 125 Gy. Results of fecundity, fertility and sperm transfer of F1 males were significantly lowered in irradiated insect combined with Bt than individual treatment.

Conclusion
Gamma irradiation treatment combined with Bt concentrations achieved a high reduction of S. littoralis, and the toxicity effect of Bt increased as compared with individual treatments taking advantage as compatible control tactics. Simultaneous treatment of IST and Bt could be considered as a competent approach for S. littoralis population suppression.
A Phase I First-in-Human Study of ABBV-383, a B-Cell Maturation Antigen × CD3 Bispecific T-Cell Redirecting Antibody, in Patients With Relapsed/Refractory Multiple Myeloma
Authors: D'Souza Anita , Shah Nina , Rodriguez Cesar , Voorhees Peter M. , Weisel Katja , Bueno Orlando F. , Pothacamury Rajvineeth K. , Freise Kevin J. , Yue Susan , Ross Jeremy A. , Polepally Akshanth R. , Talati Chetasi , Lee Shane , Jin Ziyi , Buelow Ben , Vij Ravi , Kumar Shaji 
Published: August 2022

PURPOSE ABBV-383, a B-cell maturation antigen × CD3 T-cell engaging bispecific antibody, has demonstrated promising results in an ongoing first-in-human phase I study (ClinicalTrials.gov identifier: NCT03933735 ) in patients with relapsed/refractory multiple myeloma (RRMM). Herein, we report safety and efficacy outcomes of this phase I dose escalation/expansion study. METHODS Patients with RRMM (≥ three prior lines including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody) were eligible. ABBV-383 was administered intravenously over 1-2 hours once every 3 weeks, without any step dosing. A 3 + 3 design with backfilling for dose escalation was used (intrapatient escalation to highest safe dose permitted) followed by initiation of dose expansion. RESULTS As of January 8, 2022, 124 patients (dose escalation [0.025-120 mg], n = 73; dose expansion [60 mg], n = 51) have received ABBV-383; median age was 68 years (range, 35-92 years). The most common hematologic treatment-emergent adverse events (TEAEs) were neutropenia (all grades: 37%) and anemia (29%). The most common nonhematologic TEAEs were cytokine release syndrome (57%) and fatigue (30%). Seven deaths from TEAEs were reported with all considered unrelated to study drug by the investigator. For all efficacy-evaluable patients (n = 122; all doses), the objective response rate (ORR) was 57% and very good partial response (VGPR) or better (≥ VGPR) rate was 43%. In the 60 mg dose expansion cohort (n = 49), the ORR and ≥ VGPR rates were 59% and 39%, respectively; and in the ≥ 40 mg dose escalation plus dose expansion cohorts (n = 79) were 68% and 54%, respectively. CONCLUSION ABBV-383 in patients with RRMM was well tolerated with an ORR of 68% at doses ≥ 40 mg. This novel therapy's promising preliminary antitumor activity in heavily pretreated patients warrants further clinical evaluation.
Sex Differences in In-Hospital Mortality After Open Cardiac Valve Surgery
Authors: Bradley Stephanie , White Robert S. , Jiang Silis Y. , Ma Xiaoyue , Hoyler Marguerite M. , Muehlschlegel Jochen D. , Karamnov Sergey , Tangel Virginia E. , Lanahan Jill , Rong Lisa Qia 
Published: August 2022

BACKGROUND:
Cardiac valvular disease affects millions of people worldwide and is a major cause of morbidity and mortality. Female patients have been shown to experience inferior clinical outcomes after nonvalvular cardiac surgery, but recent data are limited regarding open valve surgical cohorts. The primary objective of our study was to assess whether female sex is associated with increased in-hospital mortality after open cardiac valve operations.

METHODS:
Utilizing the Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID), we conducted a retrospective cohort study of patients who underwent open cardiac valve surgery from 2007 to 2018 in Washington, Maryland, Kentucky, and Florida; from 2007 to 2011 in California; and from 2007 to 2016 in New York. The primary objective of this study was to estimate the confounder-adjusted association between sex and in-hospital mortality (as recorded and coded by SID HCUP) after open cardiac valve surgery. We used multilevel multivariable models to account for potential confounders, including intrahospital practice patterns.

RESULTS:
A total of 272,954 patients (108,443 women; 39.73% of sample population with mean age of 67.6 ± 14.3 years) were included in our analysis. The overall mortality rates were 3.8% for male patients and 5.1% for female patients. The confounder-adjusted odds ratio (OR) for in-hospital mortality for female patients compared to male patients was 1.41 (95% confidence interval [CI], 1.35–1.47; P < .001). When stratifying by surgical type, female patients were also at increased odds of in-hospital mortality (P < .001) in populations undergoing aortic valve replacement (adjusted OR [aOR], 1.38; 95% CI, 1.25–1.52); multiple valve surgery (aOR, 1.38; 95% CI, 1.22–1.57); mitral valve replacement (aOR, 1.22; 95% CI, 1.12–1.34); and valve surgery with coronary artery bypass grafting (aOR, 1.64; 95% CI, 1.54–1.74; all P < .001). Female patients did not have increased odds of in-hospital mortality in populations undergoing mitral valve repair (aOR, 1.26; 95% CI, 0.98–1.64; P = .075); aortic valve repair (aOR, 0.87; 95% CI, 0.67–1.14; P = .32); or any other single valve repair (aOR, 1.10; 95% CI, 0.82–1.46; P = .53).

CONCLUSIONS:
We found an association between female patients and increased confounder-adjusted odds of in-hospital mortality after open cardiac valve surgery. More research is needed to better understand and categorize these important outcome differences. Future research should include observational analysis containing granular and complete patient- and surgery-specific data.
Mutation detection dual correlation filter with an object-awareness module for real-time target tracking
Authors: Cao Baiheng , Wu Xuedong , Wang Yaonan , Zhu Zhiyu , Ge Huilin , Liu Runbang , Liang Mengquan 
Published: August 2022

Discriminative correlation filter (DCF) based methods have recently been widely used for visual tracking tasks. The adaptive spatiotemporal-regulation based tracker (AutoTrack) can only partially solve some limitations of the DCF framework including filter degradation and the boundary effect, but its application scenarios need to be broadened, and performance improvements are also required. To further surmount these difficulties, this paper provides an object-awareness-module based mutation detection dual correlation filter (MDDCF-OAM). The main innovation points of this work are: (1) an object-mask based context enhancer is proposed to formulate a more robust appearance model; (2) a dual filter training–learning structure is adopted to allow the dual filters to restrict each other and suppress the filter degradation effect; (3) a Gaussian label map is updated with the refined joint response map to detect and attenuate the response mutation effects. Exhaustive experiments have been conducted to test the efficiency of the suggested MDDCF-OAM on four benchmarks, namely, OTB2015, UAV123, TC128, and VOT2019. The results indicate that: (1) the introduced MDDCF-OAM surpasses nine state-of-the-art trackers; (2) the MDDCF-OAM has a real-time speed of 32 frames per second, which is sufficient for target tracking tasks in numerous scenarios, especially unmanned aerial vehicles and camera tracking.
The elimination of trachoma as a public health problem in Mexico: From national health priority to national success story
Authors: Quesada-Cubo Víctor , Damián-González Dey Carol , Prado-Velasco Francisco Gibert , Fernández-Santos Nadia Angélica , Sánchez-Tejeda Gustavo , Correa-Morales Fabián , Domínguez-Zárate Hermilo , García-Orozco Abel , Saboyá-Díaz Martha Idalí , Sánchez-Martín María Jesús 
Published: August 2022

Introduction
Mexico was the first country in the Americas and the third in the world to eliminate trachoma as a public health problem, as validated by the WHO in 2017.

Objective
To describe the critical elements that favored the elimination of trachoma as a public health problem in Mexico and the public health impact of this success.

Methodology
A revision and compilation of data and information contained in the dossier presented by the country to PAHO/WHO to obtain the validation of trachoma elimination as a public health problem was conducted by a group of delegates from the national and local trachoma prevention and control program. Data from the national and local surveillance systems and reports of actions conducted after achieving the elimination goal were also included. Critical elements that favored the achievement of the elimination goal from 1896 to 2019 were extracted.

Results
Mexico reached the elimination of trachoma in 2016 obtaining the validation in 2017. 264 communities were no longer endemic and 151,744 people were no longer at risk of visual impairment or possible blindness due to trachoma. The key to the success of this elimination process was primarily the local leadership of health authorities with sustained funding for brigades, increased access to potable water and sanitation, and key alliances with indigenous authorities, health authorities, and government institutions that contributed to the achievement of the goal. The SAFE strategy started implementation in Mexico in 2004 as a comprehensive package of interventions. SAFE stands for surgery, antibiotics, facial cleanliness, and improvement of the environmental conditions. These actions impacted drastically on the number of new cases trachmatous trichiasis (TT) and trachomatous inflammation-follicular (TF), which decreased from 1,794 in 2004 to zero in 2016.

Conclusions
The elimination of trachoma as a public health problem in Mexico is a true success story that may serve as a model example for the elimination of other neglected infectious diseases in the Americas.
Mitral Regurgitation and Serum N-Terminal Pro-Brain Natriuretic Peptide Levels in Children: A Modification of Adult Criteria
Authors: Erolu Elif , Akalin Figen 
Published: August 2022

Mitral regurgitation can result from congenital heart disease, rheumatic valve disease, or other congenital malformations of the mitral valve. Faulty valves require surgical repair or replacement. However, echocardiographic and biochemical parameters that inform surgical decision-making for adults may not be appropriate for children. To investigate whether adult parameters can be used in children, we correlated echocardiographic parameters with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in children with chronic mitral regurgitation.
Our sample comprised 45 patients and 38 healthy children. M-mode measurements, left atrial and left ventricular volumes, and Doppler and tissue Doppler echocardiograms were collected. We graded mitral regurgitation according to European Association of Echocardiography recommendations and indexed effective regurgitant area, vena contracta, and regurgitant volume to body surface area. Patients were grouped by regurgitation severity (mild vs moderate or severe) and left ventricular end-systolic dimension (normal vs enlarged).
The NT-proBNP level was higher in patients than in controls (P=0.003), higher in patients with moderate or severe regurgitation (P=0.02), and higher in patients with an enlarged left ventricle (P=0.003). Serum NT-proBNP levels correlated with effective regurgitant area (r=0.47; P=0.002), vena contracta width (r=0.46; P=0.003), regurgitant volume (r=0.32; P=0.04), left ventricular end-systolic diameter (r=0.58; P <0.001), and left atrial diameter (r=0.62; P <0.001). An NT-proBNP value of 66 pg/mL differentiated the mild regurgitation group from the moderate or severe regurgitation group.
Our results correlating NT-proBNP and echocardiographic parameters indexed to body surface area indicate that these adult criteria can be used in children to grade mitral regurgitation and inform surgical decision-making.
Faktor-Faktor yang Mempengaruhi Loyalitas Konsumen di Siloam Hospitals Kebon Jeruk dan Lippo Village
Authors: Putri Franzeska Olivia Indra , Nur Chintya , Berlianto Margaretha Pink 
Published: August 2022

Background: Customer loyalty is a major factor for all industries, including in service industry. One of the service industries is the healthcare industry. In the healthcare industry today, there’s a change approach from paternalistic (doctor-led) to patient-centered. In patient-centered approach, the patient participates for the decision of the services they will receive. If the services matched with the patient’s needs, the patient will trust and use the services again in the future, hence, will increase patient’s loyalty. The purpose of this study was to determine the effect of service quality, customer trust, and customer value on customer loyalty at the JCI standardized Siloam Hospitals.Method: Data collection in this study was conducted using an online questionnaire to 166 people who had visited Siloam Hospitals Kebon Jeruk and Lippo Village using simple random sampling method. Analysis using partial lease square-structural equation modeling (pls-sem) was carried out using the SmartPLS program to analyse the data.Results: The findings from the study are that all the variables, which are service quality (interaction quality, physical environment quality, outcome quality), customer value and customer trust, have a positive relationship to customer loyalty at Siloam Hospitals Kebon Jeruk and Lippo Village.
Analisis Pembiayaan COVID-19 di RSUP dr. Kariadi Semarang
Authors: Setyarini Yuliana , Suryawati Chriswardani , Arso Septo Pawelas 
Published: August 2022

The cost of COVID-19 services can be a burden in itself that can affect hospital budgets. Services for COVID-19 patients at RSUP dr. Kariadi has so far been running well and smoothly, but there is no detailed data and information regarding COVID-19 financing, the process of submitting a COVID-19 financing claim and its implications for finances and services as well as leadership policies at RSUP dr. Kariadi so that activities are needed to analyze the costs of COVID-19. The purpose of the study was to analyze the financing of COVID-19, the process of submitting a claim for COVID-19 and its implications for finance and services as well as leadership policies at RSUP dr. Kariadi. The research approach used in this research is descriptive. Collecting data through document observation and interviews. The sample was selected using simple random sampling and the sample size was using the Slovin formula. The results showed that there was a negative difference of Rp.-1,832,258.63 between the average real cost of COVID-19 services and those claimed for outpatients, and there was a positive difference of Rp.61,695,327.45 for inpatients. The difference is caused by the claim system using cost per day. The biggest real cost component is the cost of laboratory examinations. The process for submitting a COVID-19 claim is in accordance with applicable regulations and all submissions declared eligible and paid. From the results of the Chi-Square test, it can be seen that there is no relationship between age and real costs in inpatient care and vice versa in outpatient care, length of days of treatment affects real costs, there is a relationship between comorbidities and real costs in SL3 and SL2, and there is no the relationship between co-morbidities with real costs in SL1 and outpatient. COVID-19 has caused the number of hospital visits and revenues in general to decline. Hospital leadership implemented several policies in dealing with the implications of COVID-19, including shifting budget posts, controlling services, zoning services, limiting non-COVID-19 patient services, transferring facilities and infrastructure, and optimizing the claim process. The research results are expected to be used as input in policy making and budget planning. Keywords: Financing Analysis, COVID-19
Blockchain data privacy protection modeling based on CP-ABE algorithm
Authors: Dang Qian , Qiu Yu , Sun Biying , Yang Zhengwei , Liu Xinrui 
Published: August 2022

Abstract
With the proposal of the concept of ubiquitous power Internet of Things and the further promotion of blockchain strategy, modern information technologies such as the Internet of Things and cloud computing have been widely used in the power system. While the power grid is becoming more intelligent, it is also accompanied by the emergence of various security threats, and the power grid will face greater challenges and pressures. In this paper, aiming at the current situation of information security faced by the power grid blockchain under the cloud Internet of Things, a multi-authorization center ciphertext policy attribute encryption access control method is constructed for the power grid blockchain. It adds the function of visitor attribute update revocation, aggregates multi-dimensional data into ciphertext, and uses CP-ABE encryption to implement fine-grained access control at the dimension level. Through experimental analysis, in terms of security and functionality, this method can resist physical collision attacks and manage access rights flexibly. In terms of encryption and decryption efficiency, the encryption and decryption calculation speed of the proposed method is 6.2–15.6% higher than that of the traditional method, and the time consumption efficiency is more than 5% higher than that of other methods. It proves that this model has more advantages for open network environments such as power grid blockchain with high confidentiality requirements and large scale of users. It is of great significance to study the data security and privacy protection methods of the power grid blockchain.
On the applicability of Cu–17Zn–7Al–0.3Ni shape memory alloy particles as reinforcement in aluminium-based composites: Structural and mechanical behaviour considerations
Authors: Alaneme Kenneth K. , Mayokun Oyediran , Bodunrin Michael O. , Babalola Saheed A. , Adediran Adeolu A. , Olaleye Kayode J. 
Published: August 2022

Abstract
The potentials of CuZnAlNi shape memory alloys to serve as viable reinforcement in Aluminium matrix composites (AMCs) was investigated. The AMCs were double stir cast developed, containing 4, 6, and 8 wt% CuZnAlNi particles; and their structural characteristics and mechanical properties were compared with that of the unreinforced Al alloy and AMC containing 8 wt% SiC. Scanning electron microscopy and X-ray diffraction results show that the CuZnAlNi refined the grain size, and increase in the CuZnAlNi wt% resulted in the formation of varied AlCu-based intermetallics, apart from the primary Al rich phase. The strength indicators – hardness, ultimate tensile strength, and specific strength largely improved with increase in the CuZnAlNi wt% and were comparatively higher than that of the unreinforced Al alloy and AMC reinforced with 8 wt% SiC for the 6 and 8 wt% CuZnAlNi reinforced AMC (specific strength being the only exception). The percentage elongation and fracture toughness values of the AMCs reinforced with CuZnAlNi (12–14.5% and 10.5–12.3 MPa m1/2) were equally superior to the SiC reinforced AMC (9% and 6.5 MPa m1/2, respectively). However, a partial reduction in the % elongation was observed with the increase in the CuZnAlNi wt%. Improved matrix/particle interface bonding, matrix refinements, thermoelastic-induced compressive residual stresses, inherent ductile, and tough nature of the SMA were advanced as mechanisms responsible for the improvements in properties.
Unsicherheit der elektrischen Impedanzspektroskopie bei Schüttgütern
Authors: Bifano Luca , Fischerauer Gerhard 
Published: August 2022

Zusammenfassung
Während die prinzipielle Eignung der elektrischen Impedanzspektroskopie (EIS) zur Charakterisierung und Zustandsüberwachung von Materialsystemen gesichert ist, bestehen bei der Reproduzierbarkeit und der Unsicherheit von EIS-Messungen in Feldanwendungen vielfach noch Erkenntnislücken. Dies gilt besonders bei Schüttgütern - wir interessieren uns speziell für Gießereisande -, weil man Schwankungen bei der Schüttungsdichte oder der Befüllungshöhe von Messzellen erwarten darf. Wir haben diese offene Frage der Messunsicherheit mit einer Messzelle untersucht, bei der zwischen zwei planparallelen Elektroden wiederholt Schüttungen eingefüllt und die resultierende Impedanz der Anordnung in einem Frequenzbereich von 20 Hz bis 1MHz gemessen wurde. Die Unsicherheit der EIS-Gerätschaften an sich wurde über Wiederholungsmessungen bei gleichbleibender Messzellenfüllung bestimmt. Der Einfluss des Befüllungsvorgangs und damit der Schüttungszusammensetzung auf die Gesamtunsicherheit wurde über mehrmalige Befüllungs- Entleerungs-Zyklen mit ein und demselben Schüttgut untersucht. Es konnte gezeigt werden, dass die Gesamtmessunsicherheit klein genug ist, dass eine Klassifizierung verschiedener Sandzustände, sei es mit klassischen Methoden oder mit Hilfe von KI-Methoden, machbar erscheint.
Local and systemic effects of microbiome‐derived metabolites
Authors: Spivak Igor , Fluhr Leviel , Elinav Eran 
Published: August 2022

AbstractCommensal microbes form distinct ecosystems within their mammalian hosts, collectively termed microbiomes. These indigenous microbial communities broadly expand the genomic and functional repertoire of their host and contribute to the formation of a “meta‐organism.” Importantly, microbiomes exert numerous biochemical reactions synthesizing or modifying multiple bioactive small molecules termed metabolites, which impact their host's physiology in a variety of contexts. Identifying and understanding molecular mechanisms of metabolite–host interactions, and how their disrupted signaling can contribute to diseases, may enable their therapeutic application, a modality termed “postbiotic” therapy. In this review, we highlight key examples of effects of bioactive microbe‐associated metabolites on local, systemic, and immune environments, and discuss how these may impact mammalian physiology and associated disorders. We outline the challenges and perspectives in understanding the potential activity and function of this plethora of microbially associated small molecules as well as possibilities to harness them toward the promotion of personalized precision therapeutic interventions.