bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between the sources of confidence in overcoming major public health events and the improvement of medical students' professional identity: mediation by medical students' attention to major public health events.
Authors: Zhu Na , Zhang Zhiyuan , Xie Jun , Ou Yangli , Tan Jia , Gao Hong 
Published: October 2022

Abstract
Background
The prevalence of COVID-19 highlights the shortage of medical human resources, and improving medical students' professional identity is a key condition to improve this situation. The sources of confidence in overcoming major public health events and medical students' attention to major public health events were key factors affecting their professional identity, but no study has yet investigated the mediating role of medical students' attention to major public health events in the relationship between them. This study aims to investigate the relationship among these three in medical university students in Hunan Province.
Methods
This was a cross-sectional survey of 2,960 medical students’ questionnaires collected from three universities in Hunan Province. An intermediary model was established to evaluate the role of medical students' attention to major public health events in the sources of confidence in overcoming major public health events and the improvement of medical students' professional identity.
Results
The sources of confidence in overcoming major public health events, medical students' attention to national crisis events, the improvement of medical students' professional identity were positively associated with each other (β = 0.328 ~ 0.464, P < 0.001). The mediating effect accounted for 23.3% of the total effect and 30.4% of the direct effect. Medical students' attention to major public health events plays a partial mediating role in the relationship between the sources of confidence to overcome major public health events and the improvement of medical students' professional identity.
Conclusions
This study found that the sources of confidence in overcoming major public health events, medical students' attention to national crisis events have a signifcant predictive effect on the improvement of medical students' professional identity. Medical students' attention to major public health events mediated the relationship between the sources of confidence to overcome major public health events and the improvement of medical students' professional identity. The findings have emphasize the theoretical and practical significance of professional identity education for medical students.
Changes in key genes associated with bone remodelling during fracture healing
Authors: Wang Bin , Pan Lei 
Published: October 2022

Abstract
Objective: The classical osteoporotic signaling pathways include the four key genes (LRP5, Runx2, Osterix, and RANKL) influencing the regulation of osteogenesis and osteoclastogenesis. This study investigates the expression of these four genes associated with bone remodelling during fracture healing.
Methods: Ovariectomisedrats as an osteoporotic group were randomly divided into three groups-group A, group B, and group C. Non-osteoporotic rats as control group were likewise divided into three groups-A0, B0 and C0, using the same method. The rats were killed on the third day of fractures in groups A and A0, on the seventh day of fractures in groups B and B0, and on the fourteenth day of fractures in groups C and C0. The bone specimens were taken from the femoral fracture site, and expression level of each gene in the bone specimens was detected using RT-qPCR, Western blotting and immunohistochemistry.
Results: LRP5, Runx2, and Osterix expressions were decreased in osteoporotic rat fractures and then increased over time. The expression of RANKL was elevated in osteoporotic rat bone specimens, which decreased after that.
Conclusion: The expressions of the four genes varied with time after fracture, which could be associated with the various stages of bone repair. The four genes can inform practice in ideal interventions in the prevention and management of osteoporosis.
Sourcing the Accompanying Celadons from the Burial Complex of Ancient Xunyang City Site using EDXRF and LA-ICP-MS
Authors: Yuan Feng , Li Zihan , Hu Sheng , Wang Yulu , Chen Hongmei , Jia Lala , Liu Long , Gao Jian , Yu Yongbin , Li Jinwei , Wu Qiang , Li Qijiang 
Published: October 2022

Abstract
This paper uses a combination of EDXRF and LA-ICP-MS to analyse the chemical components including major elements and REE composition of the accompanying celadon from four different periods of tomb at the Yutu Hill burial complex on the Xunyang city site for sourcing their provenance. A comparison with the chemical composition of the products from several kiln sites producing celadon revealed that burials from the Eastern Han period and the Tang dynasty included celadon from the Hongzhou kiln, indicating a 400-year-long trade relationship between the Xunyang city site and the Hongzhou kiln. In addition, the REE composition of the accompanying celadon in tombs from the Six Dynasties and the Sui dynasty is very similar to that of Yue kiln celadon, despite their strikingly different appearance and shape. This paper concludes, based on the previous distribution of Yue kiln products in the Jiangxi region, that only the upper classes collected Yue kiln products during the initial period of their entry into Jiangxi during the Jin dynasty, but that during the Sixth Dynasty, the commoner classes also began to collect Yue kiln products.
SnP2Se6: A Chiral 2D Semiconductor for High-Performance Electronics and Optoelectronics
Authors: Chica Daniel , Sangwan Vinod , Chu Ting-Ching , Cheng Matthew , Quintero Michael , Hao Shiqiang , Choi Hyeonseon , Liu Yukun , Qian Eric , He Jingyang , Laing Craig , Gopalan Venkatraman , Wolverton Chris , Dravid Vinayak , Lauhon Lincoln , Hersam Mark , Kanatzidis Mercouri 
Published: October 2022

Abstract
The growth of novel van der Waals 2D compounds is a key ingredient in discovering new phenomena in quantum materials, optoelectronics, and energy conversion. Here, we report SnP2Se6, which is a van der Waals chiral (R3 space group) semiconductor with an indirect bandgap of 1.36–1.41 eV. Mechanically exfoliated SnP2Se6 flakes are integrated into high-performance field-effect transistors with electron mobility >100 cm2/Vs and an on/off ratio >106 at room temperature. The combination of high carrier mobility and polar symmetry of SnP2Se6 results in a high short-circuit photocurrent density exceeding 300 A/cm2 upon 532 nm wavelength irradiation at an intensity of 40 W/cm2. The biased SnP2Se6 phototransistors show high gain (>4 × 10^4) and fast photoresponse (< 4 μs). These superlative properties of SnP2Se6 present diverse opportunities for emerging optoelectronic and quantum technologies.
New Constructions of Mutually Orthogonal Complementary Sets and Z-Complementary Sequence Sets Based on Extended Boolean Functions
Authors: Xiao Hongyang , Cao Xiwang 
Published: October 2022

Abstract
Mutually orthogonal complementary sets (MOCSs) have many applications in practical scenarios such as synthetic aperture imaging systems, orthogonal frequency division multiplexing code division multiple access (OFDM-CDMA) systems and multicarrier code division multiple access (MC-CDMA) systems. Z-complementary code sets
(ZCCSs) will be useful if the practical situation focuses more on the set size. Most ofthe known constructions of MOCSs and ZCCSs based on generalized Boolean functions (GBFs) have lengths with the form of 2m or 2m+2t. Some constructions of MOCSs and ZCCSs based on other methods mostly have restrictive lengths. In this paper, we not only present constructions of an optimal ZCCS, but also construct MOCSs with flexible lengths. Both these constructions are based on extended Boolean functions. Though our proposed constructions generalize several previously known methods, we show that the parameters of these constructions are new and include previous parameters as special cases. In addition, a wide range of q-ary MOCSs and ZCCSs can be obtained by assigning different values to q.
Establishing a scenario of exposure to environmental toxins associated with nephropathies in agricultural areas of Costa Rica based on Geological Medicine
Authors: Montero-Campos Virginia , Ulloa Oscar , Siebecker Matthew , Zimmerman Amanda Jo , Weindorf David C. , Quirós Marcela , Estrada Javier , Ulate Sharon 
Published: October 2022

Abstract

Chronic Kidney Disease (CKD) of unknown origin has caused serious public health problems in specific countries in the word, such as, Sri Lanka, India and Mesoamerica. Particularly in Costa Rica the pathology and linked mortality are concentrated in the north pacific region from the country. Affected people are found predominantly in rural agricultural areas with warm climate and low altitude and to a much lesser extent in hilly elevated areas; however, the full geographic extent of the disease is still unclear. The objective of this research is to determine a scenario of exposure to toxicants in populations with high numbers of cases of CKD. Explanatory variables for the high rate of CKD were determined by means of a Poisson multivariate regression analysis at a national level. The environmental variables included hectares of cultivated and burned sugarcane, atmospheric temperatures, relative humidity, arsenic in water for human consumption, speed and direction of winds, annual average precipitation, and geographical location with respect to alti- tude. Heavy metals, including transition metals and metalloids such as arsenic, cadmium, mercury, lead, vanadium, and silicon, which even at low concentrations have the potential to cause nephrotoxicity via chronic exposure, were quantified in the soils in areas with the highest prevalence of the disease in the country. According to this quantifica- tion and analysis, these metal(loid)s may have causal relevance in the pathology of CKD. The statistical, geographical and laboratory analy- ses determined that population exposure to environmental toxicants is seasonal, occurring under the convergence of annual climatic phenomena.
A 4pL Item Response Theory examination of perceived stigma in the screening of eating disorders with the SCOFF
Authors: Barnard-Brak Lucy , Yang Zhanxia 
Published: October 2022

Abstract
We examined the psychometric properties of the SCOFF, a screening instrument for eating disorders, with consideration of the perceived stigma of items that can produce socially desirable responding. The results of the current study suggest evidence of the sufficient psychometric properties of the SCOFF in terms of confirmatory factor and item response theory analyses. However, two items of the SCOFF revealed that individuals who otherwise endorsed other items of the SCOFF were less likely to endorse the items of Fat and Food. It is hypothesized that this is the result of perceived stigma regarding those two items that prompts individuals to respond in a socially desirable way. A weighted scoring procedure was developed to counteract the performance of these two items, but the psychometric performance was only slightly better and there would be a clear tradeoff of specificity over sensitivity if utilized. Future research should consider other ways to counteract such perceived stigma.
Impairment in Sleep Health in Young Adults with Chronic Pain: a modifiable risk factor
Authors: Eissa Mohamed , Bhatia Anuj , Bansal Shikha , Renna Tania Di , McLoone Mary , Stinson Jennifer , Campbell Fiona , Brown Stephen , Sheffe Sarah , Law Yen Shuang , Kawalpreet Singh , Bosma Rachael , Singh Mandeep 
Published: October 2022

Abstract
Background: Impairments in sleep health are associated with the development or worsening of chronic pain. Further, chronic pain can cause sleep health disruption by impacting sleep onset, sleep maintenance, sleep quality, and causing daytime somnolence. However, the association between chronic pain and sleep disturbances in the young adult population is unclear.
Aim: We describe our initial experience in establishing and running a clinic for managing sleep health and chronic pain in young adults. We also describe the prevalence and the pattern of sleep disruption as well as its relationship with self-efficacy in pain management, depression, and quality of life in this cohort.
Methods: After approval from the Institutional Review Ethics board, chart review and data extraction were conducted for patients who presented at the Young Adult Clinic (YAC) at Women’s College Hospital from March 1, 2018 to April 30, 2019.
Results: Medical charts of 55 patients were reviewed with the majority being females (71%). Chronic widespread pain was the most common pain syndrome diagnosed in our patients. Insomnia was the most common sleep-health related diagnosis in our patients. Patients with disorders of sleep were more likely to report lower self-efficacy for managing pain as compared to those with no sleep disorders (p=0.023) but there was no significant difference between these two groups as regards risk for pain-related catastrophizing.
Conclusion: Impairments in sleep health may be an important modifiable risk factor for alleviating pain in young adults with chronic pain. Sleep disorders should be evaluated and addressed in this population.
Sex differences in sexual satisfaction and psychological symptoms in young adult pornography users
Authors: Czajeczny Dominik , Aurast Zuzanna , Godlewska Karolina , Mojs Ewa 
Published: October 2022

Abstract
Research indicates that men and women have different preferences and patterns of sexual behavior and the use of pornographic content. It is commonly found that men use porn more frequently. A recent study found sex differences in motivations behind porn use. Authors speculated that different motivations might lead to different outcomes. The presented study aimed to compare sex differences in the associations between pornography use, sexual satisfaction, and occurrence of psychological symptoms between high and low pornography users sampled from the general population. A sample of 179 participants between the ages of 18 to 37 completed the questionnaire containing questions about demographic data, manner, and frequency of porn use and two psychometric scales: the General Functioning Scale GFQ-58 (assessing broad psychological symptoms) and the Sexual Satisfaction Scale SSC. In general, females in the study obtained higher scores on the General Functioning Scale, presenting more psychological symptoms. Still, when considering the frequency and manner of porn use, it is men in which increased porn use was found to be associated with psychological symptoms. Presented data provide evidence that men and women might have different motivations, leading to varying outcomes of porn use. This further supports the hypothesis that it is not porn that is inherently harmful, but rather why and how you use it.
MicroRNA analysis of the lens capsule in pseudoexfoliation glaucoma and pseudoexfoliation cataract in the Indian population
Authors: Khera Alka , Ram Jagat , Khullar Madhu , Thattaruthody Faisal , Gupta Parul Chawla , Kumar Gaurav , Singh Nirbhai , Pandav Surinder Singh 
Published: October 2022

Abstract
Pseudoexfoliation syndrome (XFS) effects the intraocular pressure (IOP) and vision of eye by causing pseudoexfoliation glaucoma (XFG). miRNAs have previously been linked to the aetiology of XFS and XFG. Present study focuses on the differential expression pattern of microRNAs (miRNAs) in anterior lens capsule (ALC) of XFS and XFG. For this, RNA from ALC of XFS, XFG and control patients was subjected to miRNA array followed by validation of clinically important significantly expressed miRNAs and their targets by real-time PCR. Out of 44 differentially expressed miRNAs, miR-638 showed significant increase in expression in XFG samples as compared to XFS and control (p < 0.0001). SRY-Box Transcription Factor 2 (SOX2), potential gene target of miR-638, showed significant downregulation in XFG compared to control samples. Oxidative stress levels were also estimated by lipid peroxidation (LPO) assay, which showed significant increased oxidative stress in XFS and XFG samples. From this investigation we can conclude that miR-638 regulation of SOX2 along with disturbed oxidative-antioxidative balance might be involved in XFG pathophysiology.
The essential-use concept: a valuable tool to guide decision-making on applications for authorisation under REACH?
Authors: Figuière Romain , Borchert Flora , Cousins Ian T. , Ågerstrand Marlene 
Published: October 2022

Abstract
Background: In 2020, the European Commission published the Chemical Strategy for Sustainability (CSS) in which it aims to increase the level of protection for human health and the environment from hazardous chemicals. Part of the implementation of the CSS will involve a reform of the REACH authorisation and restriction processes. One option for the reform of the authorisation process is to implement the essential-use concept as a tool to guide decision-making on applications for authorisation to make the process more efficient and to align it with societal needs. The purpose of this study is to investigate whether changes in the legal text that defines the authorisation process, and of the amount and type of information that applicants should provide in an application for authorisation, are needed to enable an implementation of the essential-use concept.
Results: The results suggest that no fundamental changes in the regulatory requirements are needed and that applicants should already provide sufficient and relevant information to the authorities to determine if the use(s) applied for is (are) essential.
Conclusion: Although the REACH authorisation already provides a legal and practical basis for an implementation of the essential-use concept, the feasibility of the essentiality assessment and its potential to make the decision-making on applications more efficient are highly dependent on the quality of the information provided and the clearness of decision criteria.
Small Bowel Refractory Bleeding: A Retrospective Study for Causes and Surgical Management
Authors: AL-Magedi Ahmed A.S. , Xv Yifan , Wang Zhi , Xu Wei , Wu Rong , Zhang Weiyu , Tao Qingsong 
Published: October 2022

Abstract
Introduction

Small Bowel (SB) Bleeding is one of the common gastrointestinal problems, particularly in elders. The study aimed to find the causes of refractory bleeding and overcome the challenges and difficulties of surgical treatment for SB refractory bleeding.

Methods

All Patients with SB refractory bleeding who underwent surgical treatment were included in this study. Patients’ characteristics, surgical finding, and follow-up assessments were reviewed and analyzed through Hospital Information System (HIS) records from October 1st ,2014, to November 30th ,2020. All analyses were performed using SPSS v23.0.

Results

The causes of SB bleeding include Vascular lesions (Angioectasia, AVM, Dieulafoy lesions) 29.6%, Tumors (Polyps, GIST, Adenocarcinoma, and other) 24.5%, Diverticular 18.4%, Ulcers/erosion 15.3%, Inflammatory bowel disease 7.1% and other 5.1%. Patients (age < 60) were highly developed Small Bowel bleeding caused by diverticular 26.4% compared to patients (Age ≥ 60) 8.9%, while bleeding caused by vascular lesions was significantly higher in patients (Age ≥ 60) 37.8%. Other causes, such as tumors and IBD, showed no significant difference related in age. Exploratory laparotomy was the standard method of bowel extrinsic examination. The intraoperative enteroscopy enterotomy (IOE-E) and IOE-combined were performed in 52 patients (1:1). IOE-E shows lower postoperative morbidity and shorter time of operation P < 0.05 compared to the IOE-combined approach .

Conclusions

Age and exhaustive patient history can assist in finding out the etiology. IOE-E is safe, and coordination between surgeon and endoscopist is necessary for IOE if an identifiable source cannot be found in endoscopy or exploratory laparotomy alone.
Prone position PET/CT is useful in reducing gravity-dependent opacity related [18F]fluorodeoxyglucose uptake
Authors: Song Yun Hye , Moon Jung Won , Kim Yoo Na , Woo Ji Young , Son Hye Joo , Lee Suk Hyun 
Published: October 2022

Abstract
Purpose
We investigated whether [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) taken in the prone position could reduce [18F]FDG uptake in dependent lungs.
Methods
Patients who underwent [18F]FDG PET/CT in both supine and prone positions from October 2018 to September 2021 were reviewed retrospectively. [18F]FDG uptake of dependent and nondependent lungs was analysed visually and semi-quantitatively. A linear regression analysis was also performed to examine the association between the mean standardised uptake value (SUVmean) and the Hounsfield unit (HU).
Results
Totally, 135 patients (median age, 66 years [interquartile range: 58–75 years]; 80 men) were included. Dependent lungs showed significantly higher SUVmean and HU than nondependent lungs on both supine position PET/CT (sPET/CT, 0.59 ± 0.14 vs. 0.36 ± 0.09, p < 0.001; −671 ± 66 vs. −802 ± 43, p < 0.001; respectively) and prone position PET/CT (pPET/CT, 0.45 ± 0.12 vs. 0.42 ± 0.08, p < 0.001; −731 ± 67 vs. −790 ± 40, p < 0.001; respectively). In the linear regression analysis, there was a strong association between the SUVmean and HU in sPET/CT (R = 0.86, p < 0.001) and a moderate association in pPET/CT (R = 0.65, p < 0.001). One hundred and fifteen patients (85.2%) had visually discernible [18F]FDG uptake in the posterior lung on sPET/CT, which disappeared on pPET/CT in all but one patient (0.7%, p < 0.001).
Conclusion
[18F]FDG uptake of the lung had moderate-to-strong associations with HU. Gravity-dependent opacity-related [18F]FDG uptake can be effectively reduced on prone position PET/CT.
TET3 as non-invasive screening tool for the detection of fibrosis in patients with chronic liver disease
Authors: Feng Lin-Lin , Liu Ran-Yang , An Kun , Tang Shuang , Wu Jun , Yang Qin 
Published: October 2022

Abstract
Ten-eleven translocation protein 3 (TET3) is one of the key enzymes in DNA demethylation which can be expressed in liver tissues. However, the clinical value of TET3 for diagnosis and treatment have not been reported previously. Here, we investigated whether TET3 can be detected by serological methods and evaluate the diagnostic accuracy of serum TET3 for non-fibrotic hepatitis, fibrotic hepatitis and cirrhosis. 212 patients with chronic liver disease (CLD) from were enrolled in this study. Clinical and biochemical data of all cases were obtained. Enzyme-linked immunosorbent assay was used to measure the serum levels of TET3. Receiver operating characteristics (ROC) were determined to examine the diagnostic accuracy of TET3 and combination model for diagnosis fibrosis. Univariable and multivariate analyses showed that levels of TET3 and FIB-4 index were independent predictors of liver fibrosis and cirrhosis. The areas under the ROC curve of the TET3 level and fibrosis-4 index for liver fibrosis were 0.863 and 0.813, and 0.916 and 0.957 for liver cirrhosis. When the TET3 level was associated with fibrosis-4 index, the AUROC was 0.943 for liver fibrosis and 0.990 for liver cirrhosis. The TET3-fibrosis-4 model showed a highly promising positive predictive value for detecting liver fibrosis and cirrhosis different stages of (93.50% and 100%, respectively) as compared with each diagnostic tool alone. TET3 is related to the development of liver fibrosis and cirrhosis. The TET3-fibrosis-4 model could enhance discriminatory power which could be represented a promising non-invasive tool for diagnosis and screening of liver fibrosis and cirrhosis.