bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVENESS OF HEALTH EDUCATIONAL PROGRAM ON PEDIATRIC NURSES’ KNOWLEDGE REGARDING CHEMOTHERAPY ADMINISTRATION IN HIWA CANCER HOSPITAL IN SULAIMANI CITY
Authors: Sadiq Hiwa , Majeed Bahar 
Published: January 2022

Background
Cancer is the uncontrolled growth and spread of cells. Chemotherapy is a potentially life-saving medication for people with malignancies that act by targeting cancer and non-cancer rapid dividing cells. Nurses are the prominent persons exposed to these drugs during the preparation and administration of antineoplastic agents.
Objectives
To find out the effectiveness of educational program on pediatric nurses’ knowledge about chemotherapy administration.
Methods
Quasi-experimental research design (pre-posttest) has been utilized in this study. Tool of data collection was built; the program was constructed. To obtain validity (15), experts were selected from different specialties. The pilot study was done on six nurses in the pediatric department in Hiwa cancer hospital within the first two weeks of January 2018, and reliability of the tool was done. Sixty-nine nurses were selected purposively.
Data were collected in three phases; before the educational program, the data was collected as a pre-test, an educational program which was consist of 12 sessions was applied, and the last phase collected data in the same questionnaire after the educational program as post-test. Data was analyzed by using the Statistical Package of Social sciences (V-21).
Results
The result of the study has shown significant differences in mean scores between pre- and post-program application, which indicates the effectiveness of the applied program to the nurses at a P-value (<0.001).
Conclusion
According to the study’s findings, the educational program was effective, and nurses’ level of knowledge has risen after they participated in educational sessions.
Prevalence of Oromaxillofacial Lesions in Major Histopathological Centers in Sulaimani City
Authors: Salim Gasha , Mohammad Dena , Garib Balkees , Khudier Hassanain 
Published: January 2022

Objective: Oral and maxillofacial lesions are among the most prevalent oral diseases all over the world. They can be diagnosed through a thorough history and oral examination. The present study was aimed to determine the prevalence and distribution of oromaxillofacial lesions in response to sex, age, type of surgery, site of distribution, clinical presentation, and histopathological diagnosis in Sulaimani city.
Methods: A retrospective study conducted from January 2016 to December 2019 in three major histopathological centers in Sulaimani, 774 patients with oral and maxillofacial lesions were studied. Required data, including sex, age, type of surgical biopsy, site of lesions, and the clinical presentations of these lesions, were obtained from the patients' archived profiles and records. The collected data were analyzed through descriptive statistics and Chi-square test, and P-values of < 0.05 were considered significant.
Results: Over half of the patients (54.3%) were females. The patients' age ranged from 1 day to 90 years. Excisional biopsy was the most frequently conducted surgical procedure (67.8%). Intraoral soft lesions accounted for (64.2%) of the whole lesions, followed by bone lesions (20.4%). Soft tissue mass was the most common clinical presentation (62.3%). The most commonly diagnosed lesions were reactive/hyperplastic lesions (24.2%) and epithelial tumors (11.4%). There was a significant relationship between age and histopathological diagnosis as the p-value =0.000.
Conclusions: Histopathological records provide essential data that help predict the frequent site and type of the most prevalent oral and maxillofacial lesions in Sulaimani city. They can be used for prevention and treatment planning.
Esthetic and Functional Assessment of Sixty Five Patients who Underwent Rhinoplasty (A maxillofacial surgeon’s experience)
Authors: Hama Rebwar , Hawrami Falah , Amin Zanyar 
Published: January 2022

Objective: This study aims to assess patient satisfaction according to the shape and function of the nose using a rhinoplasty outcome evaluation (ROE) questionnaire, pre, and post rhinoplasty procedure.
Methods: A prospective study of sixty-five rhinoplasty patients who underwent open rhinoplasty procedures, including other nasal procedures like septoplasty or turbinoplasty in Sulaimani Surgical Teaching Hospital, department of oral maxillofacial surgery. The Rhinoplasty Outcome Evaluation (ROE) questionnaire was used for esthetic and functional assessment.
Results: In this study, sixty-five patients participated by completing the questionnaires and the follow-up period. The main reasons for rhinoplasty in our patients were: esthetic 55.4% (n=36), functional 3.1 %( n=2), and a combination of both in 41.5% (n=27) patients. Although there were no statistically significant gender differences for outcomes of rhinoplasty, statistically significant improvements were identified between the preoperative and postoperative scores for both genders. In the preoperative stage, patients recorded worse scores for anxiety and insecurity (p < 0.05). There were no differences in gender, age, cause, or literacy level in the mean postoperative scores (p > 0.05).
Conclusions: The present study suggests that the rhinoplasty cases carried out by maxillofacial surgeons have high satisfaction rates regarding final esthetic and functional results. The rhinoplasty results have a great psychological impact on the patients’ lives.
Air ozonization for prevention of bacterial and viral infections
Authors: Prylutskyi Aleksandr S. , Kapranov Sergey V. , Tkachenko Kseniia E. , Yalovega Lubov I. 
Published: January 2022

Objective. To assess the effectiveness of the low-dose air ozonation for disinfection of the air in the working room.
Materials and methods. We investigated 90 air samples (3 samples were taken weekly before and after the production meeting using the automatic sampling device of biological aerosols of air PU-1B). The total bacterial contamination, the content of staphylococci and mold spores were determined. Ozonation of the room (83.3 m3) was carried out for 20 minutes by means of domestic ozonator. The accumulated dose of ozone was 133.3 mg (1.6 mg/m3). Statistical data processing was carried out using the MedStat licensed program. The median, median error (Me me), left and right 95 % confidence intervals (95 % CI) were calculated. Paired comparisons were made using Wilcoxon's T-test.
Results. After the meeting, the total bacterial contamination of the air was 56.0 9.3 (47.078.0) CFU. The content of staphylococci and mold spores in the air was 85.5 12.5 (76.0100.0) and 44.5 6.5 (32.054.0) CFU, respectively. After ozonation, the total bacterial contamination of the air was 14.5 3.6 (10.021.0) CFU. The content of staphylococci and mold spores in the air after ozonation was 35.5 6.7 (25.052.0) and 26.0 5.0 (18.032.0) CFU, respectively. Ozonation of the room provided a significant decrease (p 0.001) in all three of the above indicators. The room ozonation carried out promoted a reliable decrease (p 0.001) in all the above mentioned parameters.
Conclusions. The above data and analysis of the literature show the possibility of using low doses of ozone for the prevention of bacterial, fungal and viral infections including SARS-CoV-2. Further study and development of reasonable modes of ozone disinfection, including low doses of ozone, is needed, as well as determination of the efficiency degree of air disinfection with non-toxic gas concentrations.
Consumer Behavior Towards Purchase Intention of Seafood Processed Products in The Province of West Nusa Tenggara
Authors: Zulkieflimansyah  , Nurjihadi Muhammad , Mandasari Jayanti , Levia Tryana Ayu , Aprirachman Rozzy 
Published: January 2022

This study aims to analyze the variables that influence purchasing decisions for processed marine products in the Province of West Nusa Tenggara. Determination of the number of respondents who will be the sample using the 10% Margin of Error (MOE) method with a total of 100 respondents consisting of several districts in West Nusa Tenggara Province. The analytical tool used in this research is Multiple Linear Regression to see the relationship between the independent variable and the dependent variable. The research was conducted using a Likert scale on each research variable with ordinal data and transformed into intervals using the Method Successive Interval (MSI), using the MS.excel application, while the Multiple Linear Regression data processing used the Stata application. The result of this research is that the consumer behavior of processed seafood in West Nusa Tenggara Province is slightly different from the conventional theory of consumer behavior, where the brand has a negative effect on purchasing decisions of 0.2129039 points, and convenience has a negative effect on purchasing decisions of 0.1199636 points. Meanwhile, price, packaging, promotion, benefits, and consumer traditions have a positive effect on purchase intention. Processed seafood products in West Nusa Tenggara Province have different consumer characteristics from other products in general.
Incidence of ischemic stroke in patients with periodic limb movements in sleep: one-year follow-up
Authors: Spektor E. D. , Magomedova K. A. , Poluektov M. G. 
Published: January 2022

Objective. To assess the influence of periodic limb movements in sleep on the incidence of acute cardiovascular events. Design and methods. Fifty-six participants aged 60–75 years were included in the study. Eligibility criteria included no history of acute cardiovascular events and the presence of 1 or more risk factors for cardiovascular diseases. Nocturnal actigraphy and cardiorespiratory monitoring were performed. Patients with apnea/hypopnea index > 5/h were excluded (n = 6). Based on periodic limb movements index (PLMI) two groups were formed: main (PLMI ≥ 15/h, n = 26) and controls (PLMI < 15/h, n = 24). The groups were prospectively observed during 1 year. The endpoints of the study were cases of acute cardiovascular events. Results. Despite the similar prevalence of common risk factors for cardiovascular diseases in two groups, the patients with PLMI ≥ 15/h have a higher incidence of ischemic stroke within 1 year (odds ratio 1,07). Conclusions. Elevated PLMI might be regarded as a potential predictor for higher risk for ischemic stroke. Nevertheless, further investigations in the field are needed.
Pleiotropic effect of chronotherapy with a fixed combination of amlodipine, lisinopril and rosuvastatin on the psychological state in elderly hypertensive patients with metabolic syndrome
Authors: Agarkov N. M. , Okhotnikov O. I. , Korneeva S. I. , Moskaleva E. O. , Moskalev A. A. , Kolomiets V. I. , Markelova A. M. , Markelova E. A. 
Published: January 2022

Background. Hypertension (HTN) in metabolic syndrome (MS) in the elderly contributes to the formation of cognitive disorders and anxiety-depressive disorders. Objective. To study the psychological state of elderly patients with HTN and MS treated by evening versus morning dosing of a fixed combination (FC) of amlodipine, lisinopril and rosuvastatin. Design and methods. In a randomized, double-blind, controlled trial 63 patients aged 60–74 years with HTN and MS received a FC of amlodipine, liiznopril and rosuvastatin at a dose of 5/10/10 mg in the evening (after 20:00 hours) (study group) And 58 patients aged 60–74 years with HTN and MS took the drug in the morning (control group). Cognitive dysfunction was assessed by Mini-Mental State Examination (MMSE), anxiety and depressive disorders were assessed by State-Trait Anxiety Inventory adapted by Yu. Khanin and scale of the Center for Epidemiologic Studies-Depression (CES-D). Results. In evening dosing group, MMSE result increased from 17,8 ± of 0,3 to 23,5 ± 0,4 points (р = 0,13) vs. 16,9 ± of 0,3 to 20,4 ± 0,4 points (р = 0,148) in morning dosing. Situational anxiety score decreased from 40,0 ± 2,2 to 30,6 ± 1,8 points (р = 0,009) vs. from 40,8 ± of 2,5 to 33,5 ± 1,9 points (р = 0,011), and personal anxiety score from 48,8 ± 2,0 to 26,4 ± of 1,9 points (р = 0,003) and from 44,9 ± of 1,9 to 30,7 ± of 1,7 points (р = 0,008) in evening and morning dosing, respectively. Depressive disorders decreased similarly and slightly in both groups (14,1% versus 7,7% in evening and morning dosing, respectibely, p = 0,214). Conclusions. The results indicate that chronotherapy is more effective than the traditional use of a FC of amlodipine, lisinopril and rosuvastatin in HTN associated with MS.
Age and sex differences in sleep disorders as risk factors and markers of hypertension in young people with normal body weight
Authors: Kalinkin A. L. , Sorokin A. S. 
Published: January 2022

Objective. To assess age and sex differences in sleep disorders as risk factors and markers of hypertension (HTN) in 18–39-year old people with normal body weight. Design and methods. We performed a cross-sectional study based on the internet survey of 18–39-year-old people with body mass index of 18–25 kg/m2 (n = 2094). The unvalidated questionnaire included 42 questions about various types of sleep disorders and sleep-associated symptoms (0 — never, 1 — rarely, 2 — from time to time, 3 — quite often, 4 — almost all the time). Results. The probability of detecting HTN in young men with normal body weight is higher than in women with similar characteristics (p < 0,001). In women, the probability of detecting HTN decreases, starting with the youngest category (18–24 years old), reaching a minimum in the age group 30–34 years old and then starts to increase. By the age of 40, the indicators for men and women become similar. Based on a multivariate analysis, the risk of HTN in young people with normal body weight is associated with both gender and age (p = 0,022). The contribution of gender to age-related changes in sleep complaints was found for snoring (p < 0,001), sleep apnea (p < 0,001), early awakenings (p = 0,002). The contribution of gender was also noted for various symptoms — daytime sleepiness, some symptoms of restless legs syndrome (RLS), anxiety, depression, leg cramps (p < 0,001) and nocturnal heartburn (p < 0,001). The contribution of age was noted for snoring (p < 0,001), sleep apnea (p < 0,001), early awakenings (p < 0,001) and for a variety of symptoms — daytime sleepiness, some symptoms of RLS, anxiety, nocturnal cough, and nocturnal choking. Conclusions. Our data can be considered when developing measures for HTN prevention, can be recommended for clinical use, as well as in subsequent clinical studies using validated questionnaires.
Ética, Desarrollo Sostenible y Responsabilidad Social desde la docencia en instituciones de educación superior latinoamericanas
Authors: García Rangel Fabiola , Vega Cano Rosa , Vallaeys François 
Published: January 2022

El presente documento muestra los resultados de un análisis de las reflexiones vertidas por docentes y funcionarios universitarios de ocho países de América Latina, quienes participaron en las dos ediciones de un diplomado internacional, producto de la colaboración entre la Unión de Responsabilidad Social Universitaria Latinoamericana (URSULA) y la Universidad Michoacana de San Nicolás de Hidalgo, cuyo eje de trabajo fue el análisis del impacto que tiene la labor docente sobre el desarrollo sostenible.
El estudio se desarrolló desde un enfoque mixto. Mediante un análisis de contenido se analizaron cualitativamente 410 contribuciones realizadas por quienes participaron en el diplomado y, posteriormente, se llevó a cabo un análisis de frecuencias para cuantificarlas en torno a los ámbitos y metas del Modelo de Responsabilidad Social Universitaria propuesto por URSULA.
El trabajo concluye señalando que la docencia universitaria debe ser revalorada, en términos de su contribución al desarrollo sostenible, pues a través de su ejercicio se materializa la pertinencia social de la formación profesional mediante el desarrollo de prácticas y contenidos que acerquen al estudiantado a la realidad económica, social y ambiental en que viven.
Palabras clave: Ethics, Sustainable Development and Social Responsability from university teaching in Latin American higher education institutions
Changes in Prescribing Antithrombotic Therapy in Patients with Atrial Fibrillation in the Multidisciplinary Hospital in Volgograd from 2012 to 2020
Authors: Gerasimenko A. S. , Shatalova O. V. , Gorbatenko V. S. , Petrov V. I. 
Published: January 2022

Aim. To study the frequency of prescribing antithrombotic agents in patients with non-valvular atrial fibrillation (AF) in real clinical practice, to evaluate changes of prescriptions from 2012 till 2020.Material and methods. The medical records of inpatients (Form 003/y) with the diagnosis AF, hospitalized in the cardiological department were analyzed. According to the inclusion criteria, the patients were over 18 years of age, established diagnosis of non-valvular AF. There were two exclusion criteria: congenital and acquired valvular heart disease and prosthetic heart valves. In retrospective analysis we have included 263 case histories in 2012, 502 ones in 2016 and 524 in 2020. CHA2DS2-VASc score was used for individual stroke risk assessment in AF. The rational use of the antithrombotic therapy was evaluated according with current clinical practice guidelines at analyzing moment.Results. During period of observation the frequency of antiplatelet therapy significantly decreased from 25,5% to 5,5% (р<0.001), decreased the frequency of administration of warfarin from 71,9% to 18,3% (р<0.001). The frequency of use of direct oral anticoagulants increased in 2020 compared to 2016 (р<0.001). For patients with a high risk of stroke anticoagulant therapy was administered in 71.8% of cases in 2012, 88.5% in 2016 and 92.5% in 2020. Before discharge from hospital majority of patients (72%) achieved a desired minimum international normalized ratio (INR) from 2.0 to 3.0 in 2012. In 2016 and 2020 an only 33% and 40.6% of patients achieved INR (2.0-3.0).Conclusion. Doctors have become more committed to following clinical guidelines during the period of the investigation. In 2020 antithrombotic therapy for atrial fibrillation was suitable according to current clinical guidelines.
Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation
Authors: Pavlova T. V. 
Published: January 2022

The increase in the life expectancy of the population is accompanied by an increase in the prevalence of diseases for which old and senile age are risk factors. Atrial fibrillation (AF) and chronic kidney disease (CKD) are two diseases that can coexist in a patient. The risk of ac thromboembolic and hemorrhagic events in this case increases due to the mutual aggravating influence of these diseases. In addition, these patients have a high incidence of coronary events, and cardiovascular complications are the main cause of death in patients with AF and CKD. Consequently, such patients require an integrated approach to treatment, and their management is a complex clinical task. The direct oral anticoagulant rivaroxaban has been most studied in a population of comorbid AF and CKD patients and has proven a high efficacy and safety profile in these patients in randomized controlled trials. In addition, rivaroxaban has shown a significant reduction in the risk of myocardial infarction in various patients, as well as the possibility of preserving renal function to a greater extent compared with warfarin therapy, and a possible positive effect on reducing the risk of cognitive impairment. A single dosing regimen can improve adherence to treatment, which is one of the key conditions for achieving the above effects. Thus, these factors make it possible to achieve comprehensive protection of comorbid patients with AF and CKD.
GROUNDSTROKE TRAINING MODEL BASED ON SITUATION GAME FOR FIELD TENNIS ATHLETES AGED 12-14 YEARS
Authors: Zuhra Divya , Junaidi  , Nofi Marlina Siregar  
Published: January 2022

This study aims to create a game situation-based groundstroke forehand and groundstroke backhand training model for tennis athletes aged 12-14 years and improve forehand and backhand skills using a game situation-based groundstroke training model for athletes aged 12-14 years. The research method used is the Research & Development Research & Development (R&D) Borg and Gall method. Subjects studied were 15 people and were athletes aged 12-14 years. The results of the pre-test test obtained an average of 31.73. Then, the post-test obtained an average of 40.00. The exercise correlation coefficient before and after the exercise model was given was 0.946 with a p-value of 0.00 < 0.05, so the conclusion was significant. In the mean difference test with SPSS, the mean = 8.26667 shows the difference between the pre-test and post-test, the result of t-count = 26,183, df = 19 and p-value = 0.00<0.05, which means there is a significant difference between before and after being given game situation based groundstroke training model treatment. Based on these results, it can be concluded that the game situation-based groundstroke training model for tennis athletes at the age of 12-14 years is effective and can improve the forehand groundstroke.
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Authors: Hansen Justine , Shafiei Golia , Markello Ross , Smart Kelly , Cox Sylvia , Wu Yanjun , Gallezot Jean-Dominique , Aumont Etienne , Servaes Stijn , Scala Stephanie , DuBois Jonathan , Wainstein Gabriel , Bezgin Gleb , Funck Thomas , Schmitz Taylor , Spreng R. Nathan , Soucy Jean-Paul , Baillet Sylvain , Guimond Synthia , Hietala Jarmo , Bedard Marc-Andre , Leyton Marco , Kobayashi Eliane , Rosa-Neto Pedro , Palomero-Gallagher Nicola , Shine James , Carson Richard , Tuominen Lauri , Dagher Alain , Misic Bratislav 
Published: January 2022

Abstract
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography scans in >1,200 healthy individuals to construct a whole-brain 3-D normative atlas of 18 receptors and transporters across 9 different neurotransmitter systems. We find that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncover a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we find both expected and novel associations between receptor distributions and cortical thinning patterns across 13 disorders. We replicate all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.