bluuebunny/crossref_metadata_2025_split huggingface dataset:
The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis
Authors: Hsu Chia George , Chávez Camila Lage , Zhang Chongyang , Sowden Mark , Yan Chen , Berk Bradford C. 
Published: February 2022

AbstractPyroptosis is a form of cell death triggered by the innate immune system that has been implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level, pyroptosis is characterized by cell swelling, membrane rupture, and release of inflammatory cytokines, such as IL-1β. However, the role of endogenous lipids in pyroptosis remains underappreciated. We discovered that 4-hydroxynonenal (HNE), a major endogenous product of lipid peroxidation, inhibited pyroptosis and inflammasome activation. HNE at physiological concentrations (3 µM) blocked nigericin and ATP-induced cell death, as well as secretion of IL-1β, by mouse primary macrophages and human peripheral blood mononuclear cells. Treatment with HNE, or an increase of endogenous HNE by inhibiting glutathione peroxidase 4, reduced inflammasome activation in mouse models of acute lung injury and sepsis. Mechanistically, HNE inhibited the NLRP3 inflammasome activation independently of Nrf2 and NF-κB signaling, and had no effect on the AIM2 inflammasome. Furthermore, HNE directly bound to NLRP3 and inhibited its interaction with NEK7. Our findings identify HNE as a novel, endogenous inhibitor of the NLRP3 inflammasome.
A multi-omics approach to visualize early neuronal differentiation in 4D
Authors: Samara Athina , Spildrejorde Mari , Sharma Ankush , Falck Martin , Leithaug Magnus , Modafferi Stefania , Bjørnstad Pål Marius , Acharya Ganesh , Gervin Kristina , Lyle Robert , Eskeland Ragnhild 
Published: February 2022

SummaryNeuronal differentiation of pluripotent stem cells is an established method to study physiology, disease and medication safety. However, the sequence of events in human neuronal differentiation and the ability of in vitro models to recapitulate early brain development are poorly understood. We developed a protocol optimized for the study of early human brain development and neuropharmacological applications. We comprehensively characterized gene expression and epigenetic profiles at four timepoints, as the cells differentiate from embryonic stem cells towards a heterogenous population of progenitors, immature and mature neurons bearing telencephalic signatures. A multi-omics roadmap of neuronal differentiation, combined with searchable interactive gene analysis tools, allows for extensive exploration of early neuronal development and the effect of medications.Graphical AbstractHighlightsMulti-omics charting a new neuronal differentiation protocol for human ES cellsSingle-cell analyses reveals marker genes during neuronal differentiationIdentified transcriptional waves similar to early human brain developmentSearchable tools to visualize single-cell gene expression and chromatin stateIn BriefWe have developed a novel protocol for human embryonic stem cells to study neural induction and early neuronal differentiation. Multi-omics analyses uncovered cell populations, genes and transcriptional waves defining cell fate commitment. We comprehensively describe epigenetic landscapes and gene expression and provide searchable analysis tools for exploration of the data.
SARS-CoV-2 RT-qPCR testing of pooled saliva samples: a case study of 824 asymptomatic individuals and a questionnaire survey in Japan
Authors: Oba Junna , Taniguchi Hiroaki , Sato Masae , Takanashi Masaki , Yokemura Moe , Sato Yasunori , Nishihara Hiroshi 
Published: February 2022

AbstractFrom the beginning of the COVID-19 pandemic, the demand for diagnostic and screening tests has exceeded supply. Although the proportion of vaccinated people has increased in wealthier countries, breakthrough infections have occurred amid the emergence of new variants. Pooled-sample COVID-19 testing using saliva has been proposed as an efficient, inexpensive, and non-invasive method to allow larger-scale testing, especially in a screening setting. In this study, we aimed to evaluate pooled RT-qPCR saliva testing and to compare the results with individual tests.Employees of Philips Japan, Ltd. were recruited to participate in COVID-19 screening from October to December 2020. Asymptomatic individuals (n=824) submitted self-collected saliva samples. Samples were tested for the presence of SARS-CoV-2 by RT-qPCR in both 10-sample pools and individual tests. We also surveyed participants regarding their thoughts and behaviors after the PCR screening project.Two of the 824 individuals were positive by RT-qPCR. In the pooled testing, one of these two had no measurable Ct value, but showed an amplification trend at the end of the PCR cycle. Both positive individuals developed cold-like symptoms, but neither required hospitalization. Of the 824 participants, 471 responded to our online questionnaire. Overall, while respondents agreed that PCR screening should be performed regularly, the majority were willing to undergo PCR testing only when it was provided for free or at low cost.In conclusion, pooled testing of saliva samples can support frequent large-scale screening that is rapid, efficient, and inexpensive.
Durability of Omicron-neutralizing serum activity following mRNA booster immunization in elderly individuals
Authors: Vanshylla Kanika , Tober-Lau Pinkus , Gruell Henning , Münn Friederike , Eggeling Ralf , Pfeifer Nico , Le N. Han , Landgraf Irmgard , Kurth Florian , Sander Leif E. , Klein Florian 
Published: February 2022

AbstractElderly individuals are at high risk for severe COVID-19. Due to modest vaccine responses compared to younger individuals and the time elapsed since prioritized vaccinations, the emerging immune-evasive Omicron variant of SARS-CoV-2 is a particular concern for the elderly. Here we longitudinally determined SARS-CoV-2-neutralizing serum activity against different variants in a cohort of 37 individuals with a median age of 82 years. Participants were followed for 10 months after an initial two-dose BNT162b2 vaccination and up to 4.5 months after a BNT162b2 booster. Detectable Omicron-neutralizing activity was nearly absent after two vaccinations but elicited in 89% of individuals by the booster immunization. Neutralizing titers against the Wu01, Delta, and Omicron variants showed similar post-boost declines and 81% of individuals maintained detectable activity against Omicron. Our study demonstrates the mRNA booster effectiveness in inducing Omicron neutralizing activity and provides critical information on vaccine response durability in the highly vulnerable elderly population.
Management and ownership transfer in small and medium family farms
Authors: Wiatt Renee D. , Marshall Maria I. , Musselman Ryan 
Published: February 2022

PurposeThis study investigated the succession process in small and medium family farms as two distinct but related processes of management transfer and ownership transfer. Past studies focused on the broad subject of succession, without dissecting succession into the components that it contains. Furthermore, this study aimed to evaluate which business, family and owner characteristics were significant in the progress of each process toward the actual transfer of management and ownership.Design/methodology/approachTelephone interviews were conducted to gather information from rural family businesses in Illinois, Indiana, Michigan and Ohio. A bivariate ordered probit regression was utilized to model the processes of management and ownership transfer as separate but related processes. Both management transfer and ownership transfer were modeled utilizing three distinct stages of transfer.FindingsBusiness and owner characteristics were significant to both management and ownership transfer, whereas family characteristics only influenced ownership transfer. Farm family businesses that discussed goals, identified a successor and were educated on how to start the transfer process were more likely to have made progress in both management and ownership transfer.Originality/valueThe authors contribute empirically to the literature by modeling the components of the succession process, management transfer and ownership transfer, as separate but interrelated processes. The authors specifically investigate which business, owner and family characteristics influence the progression of management and ownership transfer in farm family businesses.
Understanding influence of supply chain competencies when developing Triple-A
Authors: Huma Sehrish , Ahmed Waqar 
Published: February 2022

PurposeTo be successful in the rapidly changing global business environment, supply chains (SCs) must be agile, adaptable and aligned (Lee, 2004), a practice known as Triple-A. Therefore, the purpose of this paper is to investigate the dimensions of Triple-A SCs and their concurrent impact on all three Triple-A components.Design/methodology/approachThe relationship among these factors is analyzed through Smart PLS-structured equation modeling (PLS-SEM) for which data have been collected from 243 SC professionals working in manufacturing organizations.FindingsThe findings of this study reveal that the relationship between visibility and adaptability are directly significant but that the negative relationship between velocity and alignment is insignificant; however, indirectly these relationships have a positive impact using the mediating effect of agility over visibility and adaptability, velocity and alignment. However, the relationship of flexibility over SC Triple-A is positively significant, visibility over agility and alignment is positively significant and velocity over agility and adaptability is also positively significant, and each impact agility over adaptability and adaptability over alignment which is significant.Originality/valueThere is a shortage of empirical studies to date that empirically provide evidence of possible relationships among Triple-A and its key dimensions when attempting to obtain Triple-A. This is the first authenticated Triple-A SC conceptual framework that provides direction to better understand the dimension and significance of Triple-A.
Local worker perspectives from Nicaraguan surf tourism: revisiting career anchors in non-standard work contexts
Authors: Mielly Michelle , Peticca-Harris Amanda 
Published: February 2022

PurposeThis qualitative study explores, through the lens of Schein's (1978) career anchor theory, the internal career perceptions (self-perceived values, challenges and capabilities) of local surf workers in the highly internationalized sector of surf tourism in Nicaragua.Design/methodology/approachSemi-structured interviews were carried out with 22 local surf tourism workers. Participant experiences were analyzed using thematic analysis to distinguish their career anchor orientations.FindingsThe results indicate the sustained value and instrumentality of Schein's original career anchor theory, specifically in terms of the interconnectedness of dominant and supporting anchors and the relevance of anchor groupings for workers in non-standard working environments. The anchors of lifestyle, entrepreneurial creativity, and security and stability were closely interrelated and complementary, as participants from this context were ultimately striving for security and stability.Research limitations/implicationsFuture research should consider more explicitly the role of the socio-political, environmental or economic context in shaping the internal career self-concepts and experiences of workers.Practical implicationsThis study sheds light on the internal career drivers — the unique dilemmas, challenges, passions and motives — of local workers in a resource-constrained environment. Managers, business owners and other economic actors stand to gain important insights into the realities of workers they employ, but do not intimately understand. Such insights could be generalizable to a variety of work settings in which there are high material, social or cultural constraints.Social implicationsNon-standard work contexts and local worker voices are both thematically underrepresented in the careers scholarship. Research on these topics can contribute to broader discussions of sustainability, sustainable development goals and decolonial perspectives in social science scholarship. Bringing local workers from the Global South into view means turning scholarly attention towards less-visible “others” working alongside those having received the lion's share of academic discussion, i.e. expatriate workers on a global assignment or self-initiated expatriates, most often from the Global North.Originality/valueThis is one of the first studies to explore the career anchors of local workers in the Global South in a non-standard, non-bureaucratic vocational setting. The study sheds light on local workers' career decisions, an often-neglected perspective within international human resource management.
Coronavirus research performance across journal quartiles. Advantages of Q1 publications
Authors: Shehatta Ibrahim , Al-Rubaish Abdullah M_ , Qureshi Inaam Ullah 
Published: February 2022

Purpose
The purpose of this study is to analyze the share of coronavirus publications and its citation-based indicators in various journal impact factor quartiles to discover their relationship and analyze the advantages of Q1 publications.

Design/methodology/approach
Bibliometric analyses of world coronavirus research publications (articles and reviews) indexed in Web of Science database over 20 years among four journal quartiles were performed.

Findings
The publication and citation shares in various journal quartiles were decreased in the following order: Q1 > Q2 > Q3 > Q4. World coronavirus publications/citations share in Q1 journals were on average 1.78/4.18, 2.75/7.90 and 5.07/27.79 times greater than Q2, Q3 and Q4 publications, respectively. Moreover, similar patterns were obtained for various research performance dimensions: impact, excellence, corporate interest and funding indicators. These indicators of Q1 publications were much better than the corresponding values for world overall and infectious disease literature. Thus, there was a clear research performance advantage of Q1 coronavirus publications.

Originality/value
To the best of the authors’ knowledge, this is the first study analyzing the journal impact factor quartiles and its impact on coronavirus research performance. The results/findings of this study are useful for many stakeholders to enhance the research influence by considering journal impact factor quartiles especially Q1 journals.
Customer experience in digital banking: a review and future research directions
Authors: Chauhan Shilpa , Akhtar Asif , Gupta Ashish 
Published: February 2022

Purpose
This study aims to demonstrate digital banking’s influence on customers’ evaluation of service experience and develop a framework identifying the most significant variables of digital banking that influence the financial performance of banks.

Design/methodology/approach
This structured review of literature, guided with the preferred reporting items for systematic reviews and meta-analyses framework, takes a digital banking perspective to identify 88 articles published between 2001 and 2021, examining distinct aspects of digital banking and their impact on financial performance.

Findings
Customer experience (CE) is determined by functional clues (functional quality, trust and convenience), mechanic clues (website attributes, website design, perceived usability) and humanic clues (customer complaint handling). The study is furthered to combine CE with the service profit chain model. This study also fills the gap to understand the use of “gamification” in technology-driven banking services to enhance CE. Finally, an integrative framework is proposed to link technology-related factors (digital banking clues and gamification), customer-related factors (CE, customer satisfaction and customer loyalty) and performance-related factors (financial performance).

Practical implications
The study conceptualises a “total” CE framework that banks can use to enhance their online presence. Banking service providers could also analyse their financial results based on digital banking’s impact on customers. Besides, banks can use this framework to strategically place “game-like features” in their digital platforms.

Originality/value
This study attempts to significantly contribute to the digital marketing literature related to CE with banks. It is one of the first studies to determine gamification explicitly in banking literature.
Information source and content: articulating two key concepts for information evaluation
Authors: Vamanu Iulian , Zak Elizabeth 
Published: February 2022

PurposeLearning how to identify and avoid inaccurate information, especially disinformation, is essential for any informational consumer. Many information literacy tools specify criteria that can help users evaluate information more efficiently and effectively. However, the authors of these tools do not always agree on which criteria should be emphasized, what they mean or why they should be included in the tool. This study aims to clarify two such criteria (source credibility and soundness of content), which evolutionary cognitive psychology research emphasize. This paper uses them as a basis for building a question-based evaluation tool and draws implications for information literacy programs.Design/methodology/approachThis paper draws on cross-disciplinary scholarship (in library and information science, evolutionary cognitive psychology and rhetoric studies) to explore 15 approaches to information evaluation which conceptualizes source credibility and content soundness, two markers of information accuracy. This paper clarifies these two concepts, builds two sets of questions meant to elicit empirical indicators of information accuracy and deploys them against a recent piece of journalism which embeds a conspiracy theory about the origins of the COVID-19 pandemic. This paper shows how the two standards can help us determine that the article is misleading. This paper draws implications for information literacy programs.FindingsThe meanings of and relationships between source credibility and content soundness often diverge across the 15 approaches to information evaluation this paper analyzed. Conceptual analysis allowed the authors to articulate source credibility in terms of authority and trustworthiness, and content soundness in terms of plausibility and evidential support. These conceptualizations allow the authors to formulate two respective sets of appropriate questions, the answers to which are meant to function as empirical indicators for the two standards. Deploying this instrument provides us with the opportunity to understand why a certain article discussing COVID-19 is misleading.Originality/valueBy articulating source credibility and content soundness as the two key criteria for evaluating information, together with guiding questions meant to elicit empirical indicators for them, this paper streamlines the process through which information users can judge the likelihood that a piece of information they encounter is accurate.
Low velocity impact study of a sandwich beams using Ritz method and finite element modelling
Authors: Ali Ali Mohammed , Jasim Manar Hamid , Al-Kasob Bashar Dheyaa Hussein 
Published: February 2022

Purpose
The purpose of this paper is to present an applied method to design the low-speed contact between a mass and surface of a beam using an analytical solution based on the first-order shear deformation beam theory. Also, a simulation of impact process is carried out by ABAQUS finite element (FE) code.

Design/methodology/approach
In theoretical formulation, first strains and stresses are obtained, then kinetic and potential energies are written, and using a combination of Ritz and Lagrange methods, a set of system of motion equations in the form of mass, stiffness and force matrices is obtained. Finally, the motion equations are solved using Runge–Kutta fourth order method.

Findings
The von Mises stress contours at the impact point and contact force from the ABAQUS simulation are illustrated and it is revealed that the theoretical solution is in good agreement with the FE code. The effect of changes in projectile speed, projectile diameter and projectile mass on the results is carefully examined with particular attention to evaluate histories of the impact force and beam recess. One of the important results is that changes in projectile speed have a greater effect on the results than changes in projectile diameter, and also changes in projectile mass have the least effect.

Originality/value
This paper presents a combination of methods of energy, Ritz and Lagrange and also FE code to simulate the problem of sandwich beams under low velocity impact.
A Nash bargaining game data envelopment analysis model for measuring efficiency of dynamic multi-period network structures
Authors: Gazori-Nishabori Arezoo , Khalili-Damghani Kaveh , Hafezalkotob Ashkan 
Published: February 2022

Purpose
A Nash bargaining game data envelopment analysis (NBG-DEA) model is proposed to measure the efficiency of dynamic multi-period network structures. This paper aims to propose NBG-DEA model to measure the performance of decision-making units with complicated network structures.

Design/methodology/approach
As the proposed NBG-DEA model is a non-linear mathematical programming, finding its global optimum solution is hard. Therefore, meta-heuristic algorithms are used to solve non-linear optimization problems. Fortunately, the NBG-DEA model optimizes the well-formed problem, so that it can be solved by different non-linear methods including meta-heuristic algorithms. Hence, a meta-heuristic algorithm, called particle swarm optimization (PSO) is proposed to solve the NBG-DEA model in this paper. The case study is Industrial Management Institute (IMI), which is a leading organization in providing consulting management, publication and educational services in Iran. The sub-processes of IMI are considered as players where their pay-off is defined as the efficiency of sub-processes. The network structure of IMI is studied during multiple periods.

Findings
The proposed NBG-DEA model is applied to measure the efficiency scores in the IMI case study. The solution found by the PSO algorithm, which is implemented in MATLAB software, is compared with that generated by a classic non-linear method called gradient descent implemented in LINGO software.

Originality/value
The experiments proved that suitable and feasible solutions could be found by solving the NBG-DEA model and shows that PSO algorithm solves this model in reasonable central process unit time.