bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk early warning analysis of Asian Games contestants based on improved BP neural network
Authors: Liu Zhi , Xin Guangjie 
Published: September 2022

Abstract
Sports is a complex sports system, which fundamentally determines the objectivity and randomness of sports risks, and risks can often be predicted by certain methods. The occurrence of any risk event has its inevitability and chance, usually the result of the accumulation of risk factors to a certain stage. The occurrence of risks often needs to meet certain conditions and taking necessary means to control the existing risk factors is an effective means to reduce risks. In this study, a BP neural network model for risk early warning of Asian Games players was established, and the constructed Asian Games players' participation risk early warning model was effective and had high prediction accuracy. The network training accuracy of the early warning model is 0.003328, indicating that the model can explain about 99% of the data samples. Between the actual value and the predicted value of the model prediction results, except for individual absolute errors reaching 0.09, the remaining errors are all less than 0.05. In addition, the predicted risk of participating in the Asian Games is mainly concentrated in the two levels of medium police and light police , with light police accounting for 35%.
Psychological Treatment of a BRCA gene mutation carrier in a Clinical Genetics Service using Solution Focused Therapy (SFT): – A Case Study
Authors: Firth Clare , Tripathi Vishakha 
Published: September 2022

Abstract
This case study employs solution-focused therapy (SFT) to alleviate anxiety and bereavement symptoms in a patient with a BRCA2 gene mutation. The patient was referred to therapy following treatment for breast cancer after describing high cancer anxiety and low mood in relation to two family bereavements and her breast cancer treatment. She completed 10 sessions of SFT over 12 months. The patient reported improvements in her mood and reduction in anxiety symptoms by the fifth session. There was a set-back in therapy at the sixth session which was attributed to bereavement anniversaries and the onset of the COVID pandemic. Over four more sessions the patient resumed the improvements, and five months after the end of sessions she reported that the improvements had been sustained. She felt that the therapy had allowed her to reconnect with her existing strengths and resources and successfully move forward from her genetic cancer diagnosis.
WITHDRAWN: GRP75 modulates endoplasmic reticulum-mitochondria coupling and accelerates Ca 2+ -dependent endothelial cells apoptosis in diabetic retinopathy
Authors: Li Yan , Li Hong-Ying , Shao Jun , Zhu Lingpeng , Xie Tian-Hua , Cai Jiping , Wang Wenjuan , Cai Meng-Xia , Wang Zi-Li , Yao Yong , Wei Ting-Ting 
Published: September 2022

Abstract
Background
Endoplasmic reticulum (ER) and mitochondrial dysfunction play fundamental roles in the pathogenesis of diabetic retinopathy (DR). The communication between the mitochondria and the ER is mediated by a functional subdomain referred to as the mitochondria-associated membrane (MAM). However, the mechanism underlying material exchange between the ER and mitochondria are poorly understood. This study aimed to explore the role of IP3R1-GRP75-VDAC1 axis in modulating Ca2+ homeostasis in RMECs.
Methods
In this study, we established high glucose (HG) and advanced glycosylation end products (AGEs)-induced human retinal vascular endothelial cells (RMECs) models in vitro, and streptozotocin (STZ)-induced DR model in vivo. CCK8 assay and Calcein-AM/PI double stain were used to detect cell viability.The ER-Tracker Red Kit and MitoTracker-Green are used to co-localize ER and mitochondria. Mitochondrial Ca2+ was detected using Rhod-2 AM. Co-immunoprecipitation (co-IP) was used to examine the interaction between IP3R1, GRP75 and VDAC1. MitoSOX™ Red Probe, mPTP Assay, and JC-1 Assay are used to measure mitochondrial function. Evans blue dye, retinal PAS staining, and TUNEL assay were used to assess retinal function.
Results
Our data demonstrated that there was increased ER-mitochondria coupling in the RMECs, which was accompanied by elevated mitochondrial calcium ions (Ca2+) and mitochondrial dysfunction (mitochondrial membrane potential, ΔΨm; and mitochondrial ROS) under HG or AGEs transferred ER Ca2+ into the mitochondria. Elevated mitochondrial Ca2+ concentrations led to an increase in mitochondrial ROS and a decline in mitochondrial membrane potential. These events resulted in mitochondrial dysfunction and elevation of mitochondrial permeability, which induced cytoplasmic Cyt c/Caspase-3-mediated cell apoptosis. The above phenomenon was reversed by BAPTA-AM (an intracellular calcium chelator) and tunicamycin (TUN), a common ERS inducer. In addition, 4-PBA, (an ERS inhibitor), was shown to reverse retinal dysfunction in STZ-induced DR rats.
Conclusions
Our findings demonstrated that DR fuels the formation of ER-mitochondria coupling via the IP3R1-GRP75-VDAC1 axis, which facilitates transport of Ca2+ from the ER to the mitochondria, eventually leading to mitochondrial dysfunction and apoptosis of endothelial cells. Our results demonstrated that inhibition of ER-mitochondrial coupling, including inhibition of GRP75 or Ca2+ overload, may be a potential therapeutic target in DR.
Introducing Exogenous Energy From Hydrocolloid Wound Dressing Disrupting Human Hair Follicle Metabolism
Authors: Embí Abrahám A. 
Published: September 2022

Abstract
The development in 2016 of a novel Potassium Ferricyanide of formula (K₃[Fe(CN)₆]) based tabletop microscopy method enabled for the recording of electromagnetic energy emissions from plants and animal tissue. The microscopy method was subsequently validated and used to document inter-tissue energy exchanges of both, human blood and catalase proper with a hair follicle. As of recent in vitro research using hair follicles as sentinels support expanding an endogenous irradiation theory as disease causing mechanism introduced in 1956 and revisited in 2016 to now also include non-biological exogenous irradiation emitted by hydrocolloid based wound dressings (WD). Videos and still images are presented validating the findings of energy emitted by a small fragment of a hydrocolloid based WD penetrating a 1mm glass slide and unexpectedly delaying the evaporation time of a Potassium Ferricyanide solution surrounding a freshly plucked human hair follicle. Absorption of Incoming electromagnetic radiation is a property of (K₃[Fe(CN)₆]). The introduction of energy from an exogenous non-biological material, namely a hydrocolloid wound dressing fragment justifies inclusion in future research protocols
Sociodemographic Correlates of Low Health Literacy Skills among Cancer Survivors: National Findings from BRFSS 2016 and Implications for Precision Survivorship Care
Authors: Chen Qi , Moore John , Noel Lailea , von Sternberg Kirk , Jones Barbara 
Published: September 2022

Abstract
Purpose

The purpose of the present study is to examine the prevalence of low health literacy skills among cancer survivors and their sociodemographic correlates.

Methods

This study used 2016 Behavioral Risk Factor Surveillance System data. We conducted weighted Chi-square test and logistic regression to compare the difference in prevalence of low health literacy skills between cancer survivors and non-cancer survivors. We used multiple and multinominal logistic regressions to assess the association between sociodemographic characteristic (sex, age, race/ethnicity, marital status, education, employment and household income) and three health literacy skills (difficulty obtaining, difficulty understanding oral, and difficulty understanding written health information).

Results

Difficulty understanding oral and written information is greater among cancer survivors than non-cancer survivors. Low educational attainment and income were associated with greater difficulties with all three health literacy skills. Young adult, male, and Hispanic cancer survivors have more difficulties obtaining health information. For cancer survivors, the odds of having difficulties in three health literacy skills versus the odds of having no difficulties were higher for those who were younger than 65, Hispanic, unemployed, with education levels lower than some college and with household income under $25,000.

Conclusion

Sex, age, race/ethnicity, income, employment and education are significant indicators of different health literacy skills among cancer survivors.

Implications for Cancer Survivors

Oncology providers seek to better communicate with cancer survivors from diverse backgrounds. Intervention programs need to be tailored for different skills with different populations to meet their expectation in terms of age, language, knowledge based and culture backgrounds.
Age and feeding habits of Caml grenadier Macrourus caml in Cosmonauts Sea
Authors: Xu Siqing , Sun Peng , Zhang Chi , Li Jianchao , Xi Xiaoyu , Ma Shuyang , Zhang Wenchao , Tian Yongjun 
Published: September 2022

Abstract
Macrourus caml is a main by-catch in the Southern Ocean fishery, and a main prey species of Antarctic toothfish, which plays an important role in Southern Ocean ecosystem. In this study, age estimation and stomach content analysis were conducted by using samples collected from the Cosmonauts Sea in 2021. The main objectives of this study were to estimate the age and diet of grenadier Macrourus caml and to explore the feeding habits of Macrourus caml. Stomach content analysis showed that Macrourus caml mainly fed on Malacostraca and Sagittoidea, especially the Malacostraca accounting for over 50%. The feeding habits of male and female Macrourus caml were similar. Before maturation, Macrourus caml mainly fed on Malacostraca and Cnidaria. After maturation, Macrourus caml mainly fed on algae, Malacostraca and Sagittoidea. The feeding bias decreased and the feeding range became wider with aging. The results would provide reference for exploring the nutritional status of Antarctic benthic fish in the ecosystem.
An in-situ study of the thermal decomposition of AIBN radical chemistry using a dual mode EPR resonator
Authors: Magri Giuseppina , Barter Michael , Fletcher-Charles Jack , Choi Heungjae , Slocombe Daniel , Richards Emma , Folli Andrea , Porch Adrian , Murphy Damien M. 
Published: September 2022

Abstract
A custom-built dual mode EPR resonator was used to study the radical chemistry of AIBN thermal decomposition. This resonator enables both simultaneous in situ heating using microwaves and EPR measurements to be performed. The thermal decomposition of AIBN was compared following conventional heating methods and microwave induced (or dielectric) heating methods. Under both heating conditions, the radicals formed and detected by EPR include the 2-cyano-2-propyl (CP●) and 2-cyano-2-propoxyl (CPO●) radicals. Under aerobic conditions, the observed relative distribution of these radicals as observed by EPR is similar following slow heating by conventional or dielectric methods. In both conditions, the kinetically favored CPO● radicals and their adducts dominate the EPR spectra up to temperatures of approximately 80-90 °C. Under anaerobic conditions, the distribution can be altered as less CPO● is available. However, the observed results are notably different when rapid heating (primarily applied using a MW induced T-jump) is applied. As the higher reaction temperatures are achieved on a faster time scale, none of the ST●-CPO adducts are actually visible in the EPR spectra. The more rapid and facile heating capabilities created by microwaves may therefore lead to the non-detection of radical intermediates compared to experiments performed using conventional heating methods.
Assessment of watershed health propensity using reliability, resiliency, and vulnerability based-standard precipitation drought index and GIS: A case study of northern Maysan Governorate, southern Iraq
Authors: Al-Temmeme Ammar , Al-Abadi Alaa M. 
Published: September 2022

Abstract
A quantitative evaluation of watershed health based on climatic variability is essential for watershed management. This study used a well-known reliability, resiliency, and vulnerability water resources performance framework to assess watershed health for 7 transboundary sub-watersheds between Iraq and Iran, based on a standard precipitation drought index (SPI). The assumption is that rainfall variability is one of the main climatic factors that affect watershed health. The grided monthly rainfall data of PERSIANN (Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks) type for 37 water years (1981–2018) were used to calculate SPI and the RRV indicators were calculated with an SPI threshold of 0.1 adapted from previous studies. The non-parametric seasonal Mann-Kendall test and Sen’s slope estimator were used to investigate the trend and value of trend of rainfall and SPI dataset, respectively. The temporal and spatial variation of RRV and watershed health index (WHI) derived from RRV was mapped using geographic information system (GIS). Results revealed that rainfall data did not show any trend, while SPI showed a slightly decreasing trend. The findings of the study noted that RRV had the lowest values of 0.35, 0.19, and 1.45 for the 2017–2018 water year, while the highest values (0.96, 0.99, and 21.06) were recorded for the 1991–1992 node year. Based on the calculated RRV values in most years of the study, all sub-watersheds were considered unhealthy from the standpoint of SPI. Based on the spatial analysis, the northern and northeastern sub-watersheds had less rainfall anomaly and thus appeared relatively healthy as compared to the other parts of the study area.
Meandered CPW-fed Hexagonal Ring fractal Multi-band antenna loaded with Labyrinth Resonator
Authors: Jayarenjini Jayarenjini N 
Published: September 2022

Abstract
A multiband Coplanar waveguide (CPW)-fed Hexagonal ring fractal antenna loaded with Labyrinth resonator is proposed, fabricated and measured. The CPW-fed antenna consists of a Labyrinth Resonator (LR)which is fixed on the reverse side of the substrate and iterated Hexagonal Ring fractal on top of FR4. Effects of fractal iterations and the position of the resonator are optimized for multiband characteristics and better performance of the antenna. The impedance matching of the proposed antenna is improved by the introduction of the meandered feedline. The designed antenna has a fractional bandwidth of about 87.93% (3.67-9.43 GHz), 11.21% (9.77-10.93 GHz) and 10.96% (12.93-14.43GHz) in simulation and about 94.63% (3.42-9.43 GHz), 14.17%(9.83-11.33GHz) and 14.46% (12.95-14.97 GHz) in measurement. The overall dimension is 30 × 30 × 1.6 mm3. The experimental and simulated results of a novel meandered CPW-fed printed monopole antenna with LR are reported here, which cover up the entire Ultra Wide Band frequency spectrum with a reflection coefficient of better than -10dB.
Burden of neurological diseases in the Philippines as revealed by web searches: an infodemiological study
Authors: Alonto Anisah Hayaminnah , Apor Almira Doreen Abigail , Jamora Roland Dominic 
Published: September 2022

Abstract
Background
Due to the real time acquisition of big data from the internet, analysis of Google queries is now recognized as a valuable tool to explore and predict human behavior and interests. It has been suggested that online data can be correlated with actual health data. Although the data is not structured nor systematic, the huge data from search engines can easily identify frequencies and trends on diseases and other health concepts from a population perspective. Moreover, internet data with the use of web search advertising nowadays may not only reveal the interest of the general population but also the interests of healthcare industry as reflected by the bid prices in search terms for medications.
Objectives
In this study, we aimed to analyze the searches related to neurological diseases and nervous system drugs in the Philippines. We analyzed the monthly search volumes from Google, the most commonly used search engine in the country, and the bid prices in the web search advertising to infer the interests of the general population and the healthcare industry respectively.
Methods
Data used in this study was obtained from the Google Ads Application Programming Interface (API). This study evaluated the population’s interest in neurological disorders by using the search volumes related to neurology, either disease diagnosis or medications, as this can be a good proxy for the interest of the general population. Bid values generated in API was used as a proxy for the interests of the healthcare industry.
Results
Among the neurologic diseases listed, the most searched were attention deficit hyperactivity disorder (ADHD), migraine, and Alzheimer’s disease. ADHD has been one of the most popular health-related hashtag in social media, hence making it the most searched neurologic disease despite not being in the most prevalent diseases in the 2019 global burden of neurological disorders.
The most commonly searched drugs were medications for secondary stroke prevention such as oral antihypertensives (amlodipine, losartan, carvedilol), lipid-lowering agents (atorvastatin, simvastatin, rosuvastatin), and antiplatelets (acetylsalicylic acid, clopidogrel). Other most searched drugs were analgesics such as acetaminophen, tramadol, diclofenac, and morphine.
Conclusion
Web searches may reflect the interest of the general population and the healthcare industry and may be influenced by the frequency or social impact of the disease.
3 D Echocardiographic evaluation of Right ventricular functions . a prognostic study in pediatric population with critical pulmonary stenosis undergoing balloon pulmonary valvuloplasty.
Authors: Nour Amira , ElShahed Ghada , Zidan Mostafa , Ezzeldin Dina 
Published: September 2022

Abstract
Background :
To evaluate RV functional indices using 3D echocardiography in infants with critical pulmonary stenosis undergoing balloon pulmonary valvuloplasty and to evaluate RV indices as follow up parameters in infants with critical PS.
Results:
A total of 60 patients underwent BPV with median age of 8.5 ( range 2- 12 months ). 3D echo revealed lower RV volumes ( P <0.001) , higher FAC( P< 0.001) , higher TAPSE ( P< 0.001) , higher EF ( P < 0.001), , lower basal , mid and longitudinal RV dimension ( P< 0.001) . FAC , TAPSE and RV basal and longitudinal diameter were significantly larger by 3d echo than by 2D echo (P=0.01).
Conclusions:
In patients with critical PS undergoing BPV , assessment of RV indices using 3 D echo is more reliable and effective method to assess RV volumes and function in comparison with conventional 2D echocardiography.
Convergent genomic signatures of high-altitude adaptation among six independently evolved mammals
Authors: Lyu Tianshu , Zhou Shengyang , Fang Jiaohui , Wang Lidong , Shi Lupeng , Dong Yuehuan , Zhang Honghai 
Published: September 2022

Abstract
The species living in the Qinghai-Tibet Plateau provide an excellent model system for studying the relationship between molecular convergent evolution and adaptation. Distant species experiencing the same selection pressure (i.e., hypoxia, low temperature and strong ultraviolet radiation) are likely to evolve similar genetic adaptations independently. Here, we performed comparative genomics studies on six independently evolved high-altitude species. The results also showed that the convergent evolution of the six species was mainly reflected at the level of rapidly evolving genes, and the functions of these rapidly evolving genes were mainly related to hypoxia response and DNA damage repair. In addition, we found that high-altitude species had more gene family changes than their low-altitude relatives, except for the order Lagomorpha. The results also show that the convergence of gene family contraction of high-altitude species is much greater than that of expansion, revealing a possible pattern of species in adapting to high-altitude. Furthermore, we detected positive selection signature in four genes related to hypoxia response and ultraviolet radiation damage in these six species (FYCO1, ERBIN, SCAMP1 and CXCL10). Our study reveals that hypoxia response might play an important role in the adaptation of independently evolved species to high-altitude environment, providing a basic perspective for further exploring the high-altitude adaptation mechanism of different related species in the future.
Covid-19 and women’s attitude to work: commitment, effectivity and participation
Authors: Brunetti Irene , Corsini Lorenzo , Martelli Irene 
Published: September 2022

Abstract
In this paper we assess the Covid-19’s and lockdown’s impact on the attitude and capability of women toward work and labour force participation. We use data that we gathered from an online survey on women working conditions before and during the lockdown as well as their perspective on post-lockdown situation. We use Item Response Theory to estimate a latent measure that captures the capability of women to commit fruitfully in their work activities. Our results suggest a predictable worsening of the women working conditions and perspectives, but they also show that this worsening was not symmetric across all the categories of women.
The lockdown was particularly detrimental to women: i) working in the private sector, ii) in the younger age class (below 35) and iii) with less than tertiary education level. Interestingly, these categories were faring quite well in the pre-pandemic situation. We also find that some categories that performed poorly in terms of working capability before the pandemic were not the most hit by the Covid emergency. Our findings point to a severe risk of a withdrawal of women in terms of labour force participation and ask for policy actions to support the categories particularly exposed to this risk.
JEL CODES: C81, J6, J22
Descriptive pilot study on physiological improvements and microbiota modulation after colon cleansing in a group of young adult overweight women
Authors: CA Gonzalez-Correa , LO Tapasco-Tapasco , Gomez-Buitrago PA 
Published: September 2022

Abstract
Background
The colon is now considered as key to wellbeing, health and disease and intestinal microbiota (IM) modulation is becoming a therapeutic target for some medical conditions. Interventions for this modulation range from the traditional ones based basically on diet and exercise, to intestinal fecal (microbiota/microbiome) transplantations, through the consumption of pro- pre- and syn-biotics.
Objectives
In this descriptive pilot study, we propose a 6-day colon cleansing protocol to modulate IM and obtain visible improvements in a selected set of 22 physiological variables associated with being overweight and obesity: 11 physical, 9 chemical and 2 biological (Firmicutes/Bacteroidetes ratio – F/BR, and the prevalence of Akkermansia muciniphila).
Methods
We worked with a convenience sample of 12 young adult overweight female volunteers, divided into two groups: a control group and an experimental group, each with n = 6.
Results
Here, we show that favorable changes in all selected variables are present in the experimental group immediately after the treatment and a month later, without further intervention, and that the changes observed in the physical and chemical variables are highly correlated with the changes in the F/BR.
Conclusion
Being overweight or obese, in the same way as most chronic non communicable diseases (NCDs), are associated with unhealthy life habits, which produce epigenetic changes and alterations in the IM equilibrium (dysbiosis). As life habits are modifiable, NCDs are considered as preventable. Microbiota modulation at the beginning of a slimming intervention to restore that equilibrium (eubiosis) could prove very useful as an adjuvant to changes in diet and physical activity and improve their effectiveness. The preliminary results provided by this descriptive pilot study are very encouraging and merit a future larger clinical study in order to get solid statistical support for this proposal.