bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PDLP-NHL3 complex integrates plasmodesmal immune signaling cascades
Authors: Tee Estee E. , Johnston Matthew G. , Papp Diana , Faulkner Christine 
Published: September 2022

AbstractThe plant immune system relies on the perception of molecules that signal the presence of a microbe threat. This triggers signal transduction that mediates a range of cellular responses via a collection of molecular machinery including receptors, small molecules, and enzymes. One response to pathogen perception is the restriction of cell-to-cell communication by plasmodesmal closure. We previously found that while chitin and flg22 trigger specialized immune signaling cascades in the plasmodesmal plasma membrane, both execute plasmodesmal closure via callose synthesis at the plasmodesmata. Therefore, the signaling pathways ultimately converge at or upstream of callose synthesis. To establish the hierarchy of signaling at plasmodesmata and characterize points of convergence in microbe elicitor-triggered signaling, we profiled the dependence of plasmodesmal responses triggered by different elicitors on a range of plasmodesmal signaling machinery. We identified that, like chitin, flg22 signals via RBOHD to induce plasmodesmal closure. Further, we found that PDLP1, PDLP5 and CALS1 are common to microbe- and SA-triggered responses, identifying PDLPs as a candidate signaling nexus. To understand how PDLPs relay a signal to CALS1, we screened for PDLP5 interactors and found NHL3, which is also required for chitin-, flg22- and SA-triggered plasmodesmal responses and PDLP-mediated activation of callose synthesis. We conclude that a PDLP-NHL3 complex acts as an integrating node of plasmodesmal signaling cascades, transmitting multiple immune signals to activate CALS1 and plasmodesmata closure.Significance StatementPlants close plasmodesmata to restrict cell-to-cell communication after pathogen perception and in response to a range of stresses. All these stimuli trigger callose deposition at the plasmodesmal neck, suggesting a convergence of signaling. We have defined the hierarchy of molecular components and signals required to mediate plasmodesmal closure in immune responses, identifying a PDLP-NHL3 complex as a critical node that integrates multiple signaling cascades to regulate plasmodesmata.
Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with HIV
Authors: Levitt Danielle E. , Simon Liz , Lin Hui‐Yi , Siggins Robert W. , Ferguson Tekeda F. , Molina Patricia E. , Welsh David A. 
Published: September 2022

AbstractBackgroundAntiretroviral therapy has improved life expectancy among people living with HIV (PLWH). Despite increased longevity, PLWH are at increased risk of age‐related comorbidities, including frailty. We examined the relationship between body composition and frailty among PLWH, and moderation of this relationship by substance use, physical activity (PA), and physical function.MethodsParticipants (n = 341; 71% male, 48 ± 10 years, body mass index (BMI) = 27.3 ± 7.0 kg/m2) enrolled in the New Orleans Alcohol Use in HIV (NOAH) study underwent measures of body composition, muscle strength, and gait speed. Whole blood phosphatidylethanol (PEth) was measured, and substance use and PA were self‐reported. Frailty risk measures included the 58‐Item Deficit Index (DI58) and the Veterans Aging Cohort Study (VACS) Index 1.0, where higher scores indicate greater frailty risk.ResultsMultivariable linear regression adjusted for age, sex, and race showed that higher fat‐free mass index (FFMI), body fat (%), waist‐to‐hip ratio, and body mass index (BMI) ≥ 25.0 kg/m2 vs. < 25.0 kg/m2 were significantly (p < 0.05) associated with decreased frailty risk measured by the VACS Index, whereas adjusted analyses showed no association between body composition variables and the DI58 score. Recent alcohol use, muscle strength, and PA, but not lifetime alcohol use or gait speed, significantly moderated associations between body composition variables and frailty risk with medium‐to‐large effect sizes. Subgroup analyses revealed a negative relationship between DI58 and FFMI among people with PEth > 8 ng/ml and negative relationships of VACS Index with FFMI and WHR in people with lower muscle strength. Overweight or obese BMI categories were positively associated with DI58 in people with lower muscle strength or higher PA level but negatively associated in those with higher muscle strength.ConclusionsOur findings indicate that body composition has significant modulatory effects on frailty risk in PLWH, where obesity increases the risk of frailty and greater muscle mass may be protective, even in individuals who use alcohol. These results highlight the importance of considering body composition, physical activity, and physical function in assessing frailty risk in PLWH, particularly among individuals who use alcohol. Moreover, they support the implementation of physical activity interventions to ameliorate the risk of frailty in aging PLWH.
Utility of optical coherence tomography in basal cell naevus syndrome: A case report
Authors: Ho Genevieve , Schwartz Rodrigo J. , Melhoranse‐Gouveia Bruna , Guitera Pascale , O'Sullivan Niamh A. , Cheung Veronica K. Y. , Ch'ng Sydney , Martin Linda K. 
Published: September 2022

AbstractOptical Coherence Tomography (OCT) is a useful non‐invasive diagnostic tool for diagnosing and monitoring treatment of basal cell carcinomas. We describe the use of OCT in a patient with Basal Cell Naevus Syndrome. Through measuring tumour depth on OCT, management of individual tumours was triaged accordingly using 0.4 mm tumour depth as a cut‐off for surgical and non‐surgical management. OCT has potential to reduce unnecessary excisions and associated morbidity in this population of patients.
The Role of Marital Status in the Online Lending Market: Evidence from the Renrendai Platform
Authors: Huang Wenli , Chen Anyun , Qian Yanhong 
Published: September 2022

AbstractBased on data from the Renrendai platform in China, this paper studies the impacts of marital status on funding success and default. Probit models are employed to perform the main regressions. The empirical results show that married borrowers have the highest rate of funding success, followed by divorced and single borrowers. Although the default risk of divorced borrowers is higher than that of married borrowers, it is not different from that of single borrowers. In addition, this paper uncovers an important joint effect of marital status and education on online lending.
Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study
Authors: Khalifa Fatma Nada , Hosny Sara Adel , Matter Lamiaa Mohammed , Ramadan Nagwa Mahmoud , Fattah Amani Abdel , Moawad Asmaa Mohammad 
Published: September 2022

AbstractBisphenol S (BPS) is used as an alternative to bisphenol A (BPA) in polycarbonate plastics, epoxy resins and thermal receipt sheet manufacturing. We examined the toxic effects of BPS on gastric and renal functions, as well as the efficacy of allopurinol as a treatment. Albino rats were given only BPS (30 and 120 mg/kg BW/day), and some were treated with allopurinol prior to sacrifice. Gastric and renal specimens were evaluated histologically and immunohistochemically, and blood from the tail vein was analysed for levels of gastrin, uric acid (UA), erythropoietin and 8‐deoxyguanosine (8‐OHdG). Gastrin levels decreased while erythropoietin, UA and 8‐OHdG levels increased significantly. The severity of gastric and renal damage observed in BPS‐treated animals increased with increasing doses. The mean percentage of COX‐2 immunoreactivity and the mean number of CD45 immunoreactive cells were significantly increased in the stomach and kidney of BPS rats. Allopurinol ameliorated the biochemical, histological and immunohistochemical alterations induced by BPS, with superior protection at lower doses. Allopurinol can reverse the effects of BPS on the stomach and kidneys.
Echocardiographic diagnosis of a large coronary artery fistula in a newborn
Authors: Masci Marco , Moras Patrizio , Campanale Cosimo Marco , Guk Yeva , Donato Valeria , Toscano Alessandra 
Published: September 2022

AbstractCoronary artery fistula (CAF) is a rare cause of heart murmur in newborns, with a very heterogeneous clinical presentation and unpredictable natural history. We described the case of a large neonatal CAF in an asymptomatic newborn. The patient did not show any symptoms of heart failure during a three‐month follow‐up. In this case, echocardiography was as accurate as CT scan in describing the anatomy and the course of CAF.
Closing the door in front of a torrential mitral regurgitation
Authors: Mansour Mohamad Jihad , Natalis Alexandre , Masson Jean‐Bernard , Potvin Jeannot , Romanelli Giovanni 
Published: September 2022

AbstractBackgroundTreatment of symptomatic severe mitral regurgitation (MR) is challenging in patients who are not candidates for surgical intervention.Case DescriptionWe report the case of a 64‐year‐old female with multiple comorbidities who was found to have severe MR due to a large mitral valve non coaptation.ConclusionsIn this case report, we show the potential of transcatheter edge‐to‐edge mitral valve repair using MitraClip for the treatment of torrential MR due to a large mitral valve non‐coaptation in a patient with no prior history of coronary artery disease and in whom surgical intervention was not an option.
Mapping the graduating European dentist to established undergraduate dental education activities at Trinity College Dublin
Authors: van Harten Maria T. , O'Connell Brian , Duane Brett , Nolan Audrey 
Published: September 2022

AbstractIntroduction“The Graduating European Dentist” Curriculum (GED) was adopted in 2020 by the Irish Dental Council as its new expectation for competencies. The Dublin Dental University Hospital (DDUH) sought to map the teaching activities for its undergraduate dental training programme to the GED. This paper describes the process developed for curriculum mapping.Materials and MethodsGuided by historical mapping data and materials on the DDUH's virtual learning environment; teaching activities in a bespoke curriculum mapping system were edited, added and/or deleted to match existing teaching activities currently delivered by staff to students. These activities were then remapped to GED Learning Outcomes. Staff members with oversight responsibilities for a collection of activities then received and provided feedback on reports tabulating the preliminary map. Feedback from staff members around their activities was accommodated to produce an accurate reflection of teaching activities across the 5 years program.ResultsA process for mapping existing teaching activities to a new set of curriculum expectations using a bespoke application and several other widely available technologies was established. Informal feedback from staff has been positive and has raised ideas for future opportunities to improve the alignment of educational activities with learning outcomes.ConclusionOther dental schools may find this accounting of the DDUH's efforts useful in guiding their own curriculum mapping.
Artificial neural network and dataset optimization for implementation of linear system models in resource‐constrained embedded systems
Authors: Sami Abdul , Asif Ali , Imran Muhammad , Aziz Farah , Noor Muhammad Yasir 
Published: September 2022

AbstractOn‐board training of artificial neural network (ANN) is important in instances where real time data are required for model training. Provision of on‐board intelligence enables the developed systems to self‐recalibrate and enhances their efficiencies. In this work, investigations have been performed to determine optimized parameters of ANN model for linear systems. The performance parameters that is, model parameters, memory requirements, accuracy and processing time are chosen by considering the model to be installed on commercially available microcontrollers that have very limited on‐board memory. Minimum data requirements for training ANN models of linear systems are also explored for better performance. All dataset ranges are normalized in order to exclude the effects of range differences. It is shown that for linear systems, 1–3–1 architecture produces best results against ≤100 data points when Bayesian Regularization (BR) training function is used along with Log Sigmoid Activation function. Simulations for 1–3–1 architecture are then performed for datasets having 10, 25, 50 and 100 data points. The results show that training with 25 data points produces over‐all better performance than other datasets. A large dataset utilizes more training time and memory whereas a smaller dataset produces relatively lesser accuracy. The effects of clustered data and uniformly distributed data are also explored. It is found that total epochs in case of clustered data are significantly higher than uniformly distributed data. The combination of these optimized parameters that is, 1–3–1 architecture, with BR and Log function, for ≤100 data points can be used for the development and implementation of linear components or systems in resource‐constrained embedded systems.
Fatigue behavior and mechanism of dog‐bone‐shaped specimens of FV520B‐I in a very high cycle regime
Authors: Zhang Ming , Zhang Han , Li Mengli , Liu Long , Wang Pengfei 
Published: September 2022

AbstractThe fatigue properties of dog‐bone‐shaped specimens of FV520B‐I base metal and the welded joint up to 109 cycles were obtained. The S–N curves of the dog‐bone‐shaped specimens were lower than that of the funnel‐shaped specimens, and the S–N curves of welded joint specimens moved downward compared with that of base metal specimens. For all types of specimens, cracks initiating from the surface matrix and cracks initiating from subsurface inclusions were the main cracking modes in the high cycle regime and the very high cycle regime, respectively. The Murakami model and the modified model were used to predict the fatigue strength at 109 cycles. The parameter D* = NG / Ns was used to characterize the competition of different cracking modes, and the expression of the critical radius rc was obtained. Combined with the Gumbel distribution curve of the inclusion size, the probabilities of subsurface cracking and surface cracking were obtained.
Burnout, quality of life and perceived patient adverse events among paediatric nurses during the COVID‐19 pandemic
Authors: Khatatbeh Haitham , Al‐Dwaikat Tariq , Alfatafta Huda , Ali Amira Mohammed , Pakai Annamária 
Published: September 2022

AbstractPurposeThis cross‐sectional, descriptive, correlational study aimed to measure burnout, quality of life (QOL) and perceptions of patient‐related adverse events among paediatric nurses amid the COVID‐19 pandemic and assess the relationships between these scores and participants' demographic and work‐related characteristics.BackgroundThe mental health of most nurses may severely suffer due to the significant adversities that they struggle with while they care for their patients amid the COVID‐19 pandemic. Mental distress negatively affects nurses' relationships and work performance, which may adversely influence the quality of care and patient safety.MethodsA convenient sample of 225 Jordanian paediatric nurses completed a test batter comprising the Copenhagen Burnout Inventory, the Brief Version of the World Health Organisation's Quality of Life questionnaire and the nurse‐perceived patient adverse events' questionnaire. This study was prepared and is reported according to the STROBE checklist.ResultsPaediatric nurses reported high levels of burnout, low QOL and high occurrence of hospital‐acquired infections. Participants' age and hospital/unit capacity were significantly associated with burnout and QOL.ConclusionPersonal traits, perceived salary insufficiency and hospital/unit capacity represent factors that aggravate burnout, lower quality of life and worsen perceived patient safety among paediatric nurses.Relevance to clinical practicePolicymakers should promote nurses' mental integrity and patient safety by addressing issues of workload and financial sufficiency and by provide interventions aimed to increase nurses' resilience.Patient or public contributionPatients or public were not involved in setting the research question, the outcome measures, the design or implementation of the study. However, paediatric nurses responded to the research questionnaires.
Asset Pricing with Cohort‐Based Trading in MBS Markets
Authors: FUSARI NICOLA , LI WEI , LIU HAOYANG , SONG ZHAOGANG 
Published: September 2022

ABSTRACTAgency mortgage‐backed securities (MBSs) with diverse characteristics are traded in parallel through individualized specified pool (SP) contracts and standardized to‐be‐announced (TBA) contracts with delivery flexibility. This parallel trading environment generates distinctive effects on MBS pricing and trading: (i) Although cheapest‐to‐deliver (CTD) issues are present in TBA trading and absent from SP trading by design, MBS heterogeneity associated with CTD discounts affects SP yields positively, with the effect stronger for lower‐value SPs; (ii) high selling pressure amplifies the effects of MBS heterogeneity on SP yields; and (iii) greater MBS heterogeneity dampens SP and TBA trading activities but increases their ratio.
Contracting with multiple suppliers: A multi‐item buyer's make versus buy decision
Authors: Chaturvedi Aadhaar 
Published: September 2022

We consider a multi‐item buyer's make versus buy decision. The buyer sells two substitutable products with uncertain demand. Each product requires a different item, which the buyer procures from two separate suppliers (one for each item) who offer quantity‐payment contracts under asymmetric information. The buyer can make one of the items but not both. We compare the buyer's expected profit between buying both the items and making one item (and buying the other), when it can make the item at the same cost as the supplier, as well as gain reactive production capability by making. We find that the buyer's profit when buying both items is higher than for making one item if product substitutability is above a threshold (but not extremely high). This is because the interaction between the suppliers' contracts increases the buyer's informational rents more when buying from both suppliers, as compared to one supplier, as product substitutability increases. On the contrary, in the complete information scenario (and under wholesale price contracts), we find that the buyer will never prefer to buy both the items as compared to making one item, as long as product substitutability is not extremely high. These are novel findings on how inter‐linked contracts under incomplete information and product substitutability can influence a buyer's make versus buy decision in a counter‐intuitive manner. Managerially, these results imply that a multi‐product buyer may prefer to keep buying from its supplier even when it can produce the item at the same cost as the supplier.
How do macro‐ and micro‐level changes interact in the emergence of educational outcomes?
Authors: Blossfeld Pia Nicoletta 
Published: September 2022

AbstractThis article uses data from the National Educational Panel Study (NEPS) to examine how the composition of tertiary degree holders by social origin has changed across cohorts during a period of massive educational expansion. It also investigates how changes in the composition of social origins affect the proportion of downward mobility of children from academic families. The results of the empirical analysis reveal a surprising paradox: On the one hand, the rising share of children from academic families across cohorts has contributed to an increasing share of children from academic families among tertiary graduates. This is because of both the macro‐level proportion of children from academic families and the micro‐level probability of these children to obtain a tertiary degree have increased across cohorts. Thus, these macro‐level and micro‐level changes have reinforced each other. On the other hand, this change in the composition of social origin has also contributed to an increasing proportion of children from academic families who are downward mobile in successive cohorts. This is because the macro‐level share of children from academic families has increased more across cohorts than their downward mobility risk has decreased at the micro level. Thus, macro‐level changes were stronger and went in opposite direction to micro‐level changes.
A Violência Divina de Benjamin e o Caso de Coré – A Rebelião contra Moisés Como Primeira Cena do Messianismo (Números, 16)
Authors: Bojanic Petar 
Published: September 2022

Texto originalmente publicado em: BOJANIC, Petar. Violence and messianism. Jewish Philosophy and the Great Conflicts of the 20th Century. Londres/Nova Iorque: Routledge, 2018. p. 99-114.
Exploratory Examination of Knee Self-Efficacy in Individuals With a History of ACL Reconstruction and Sport-Related Concussion
Authors: Genoese Francesca M. , Zynda Aaron J. , Ford Kayla , Hoch Matthew C. , Hoch Johanna M. , Covassin Tracey , Baez Shelby E. 
Published: September 2022

Context: Knee self-efficacy and injury-related fear are associated with poor self-reported knee function and decreased physical activity (PA) after ACL reconstruction (ACLR). Limited research has explored contextual factors that may influence psychological responses in this population, such as history of sport-related concussion (SRC). After SRC, individuals may experience increased negative emotions, such as sadness and nervousness. However, it is unknown how SRC history may influence knee-self efficacy and injury-related fear in individuals with ACLR. The purpose of this study was to compare knee self-efficacy and injury-related fear in individuals after ACLR who present with and without history of SRC. Design: Cross-sectional study. Methods: Forty participants ≥1 year postunilateral ACLR were separated by history of SRC (no SRC = 29, SRC = 11). The Knee Self-Efficacy Scale (KSES) and subscales measured certainty regarding performance of daily activities (KSES-ADL), sports/leisure activities (KSES-Sport), physical activities (KSES-PA), and future knee function (KSES-Future). The Tampa Scale of Kinesiophobia-11 measured injury-related fear. Mann–Whitney U tests were used to examine between-group differences. Hedges g effect sizes and 95% confidence interval were used to examine clinically meaningful group differences. Results: Individuals with a history of ACLR and SRC demonstrated worse KSES-PA (7.5 [5.3]) compared with those without a history of SRC (8.1 [6.1], P = .03). No other statistically significant differences were observed. A medium effect size was present for the KSES-PA (0.62), KSES-ADL (0.42), KSES-Present (ADL + PA + Sport) (0.48), KSES-Total (0.53), and Tampa Scale of Kinesiophobia-11 (0.61) but must be interpreted with caution as 95% confidence interval crossed 0. Conclusions: This exploratory study indicated that individuals with a history of ACLR and SRC had worse knee self-efficacy for PA compared with those without history of SRC. Rehabilitation specialists should monitor knee self-efficacy deficits in the post-ACLR population and recognize the potential influence of cumulative injury history on rehabilitative outcomes.