bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors for cervical kyphotic deformity following laminoplasty: a systematic review and meta-analysis
Authors: Pettersson Samuel D. , Skrzypkowska Paulina , Ali Shan , Szmuda Tomasz , Krakowiak Michał , Počivavšek Tadej , Sunesson Fanny , Fercho Justyna , Miękisiak Grzegorz 
Published: September 2022

OBJECTIVE
Laminoplasty is a common treatment for cervical spondylotic myelopathy (CSM) and for ossification of the posterior longitudinal ligament (OPLL). However, approximately 21% of patients undergoing laminoplasty develop cervical kyphotic deformity (KD). Because of the high prevalence rate of KD, several studies have sought to identify predictors for this complication, but the findings remain highly inconsistent. Therefore, the authors performed a systematic review and meta-analysis to establish reliable preoperative predictors of KD.

METHODS
PubMed, Scopus, and Web of Science databases were used to systematically extract potential references. The first phase of screening required the studies to be written in the English language, involve patients treated for CSM and/or OPLL via laminoplasty, and report postoperative cervical KD. The second phase required the studies to provide more than 10 patients and include a control group. The mean difference (MD) and odds ratio (OR) were calculated for continuous and dichotomous parameters. Study quality was evaluated using the Newcastle-Ottawa Scale. CSM and OPLL patients were further assessed by performing subgroup analyses.

RESULTS
Thirteen studies comprising patients who developed cervical KD (n = 296) and no KD (n = 1254) after receiving cervical laminoplasty for CSM or OPLL were included in the meta-analysis. All studies were retrospective cohorts and were rated as high quality. In the combined univariate analysis of CSM and OPLL patients undergoing laminoplasty, statistically significant predictors for postoperative KD included age (MD 2.22, 95% CI 0.16–4.27, p = 0.03), preoperative BMI (MD 0.85, 95% CI 0.06–1.63, p = 0.04), preoperative C2–7 range of flexion (MD 10.42, 95% Cl 4.24–16.59, p = 0.0009), preoperative C2–7 range of extension (MD −4.59, 95% CI −6.34 to −2.83, p < 0.00001), and preoperative center of gravity of the head to the C7 sagittal vertical axis (MD 26.83, 95% CI 9.13–44.52, p = 0.003). Additionally, among CSM patients, males were identified as having a greater risk for postoperative KD (OR 1.73, 95% CI 1.02–2.93, p = 0.04).

CONCLUSIONS
The findings from this study currently provide the largest and most reliable review on preoperative predictors for cervical KD after laminoplasty. Given that several of the included studies identified optimal cutoff points for the variables that are significantly associated with KD, further investigation into the development of a preoperative risk scoring system that can accurately predict KD in the clinical setting is encouraged.
PROSPERO registration no.: CRD42022299795 (https://www.crd.york.ac.uk/PROSPERO/).
Evaluation of Anterior Fontanelle Sizes and Closure Time in Children with Computed Tomography
Authors: ÇIRACI Saliha , ÖZDEMİR Öner 
Published: September 2022

Amaç: Bu çalışmada 0-24 ay arası çocuklarda ön fontanel (ÖF) kapanma zamanı ve boyutlarını değerlendirmeyi amaçladık. Bu çalışmanın ikincil amacı ise ÖF boyutu ve subaraknoid mesafe genişliği arasındaki ilişkinin araştırılmasıdır.
Gereç ve Yöntemler: Bu çalışmada Ocak 2020 ve Ekim 2021 tarihleri arasında hafif kafa travması nedeniyle bilgisayarlı tomografi (BT) çekilen olguların görüntüleri retrospektif olarak değerlendirildi. 3D BT görüntüleri üzerinde ön fontanel kapanması (ÖFK) değerlendirildi ve açık olanlarda ÖF alanı ölçüldü. Aksiyal BT görüntülerde subaraknoid mesafe ölçümleri gerçekleştirildi.
Bulgular: Hafif kafa travması nedeniyle BT çekilen 602 çocuk çalışmaya dahil edildi. 0-24 ay arasında her aylık yaş grubunda 23-25 olgu mevcuttu. K/E oranı 284/317 idi. Radyolojik olarak 0-6 ay arası, klinik olarak 0-2 ay arası ÖFK izlenmedi. Klinik ÖFK 3. ayda başlayıp 13. ayda % 66’ya 15. ayda % 90’ın üzerine, radyolojik ÖFK ise 7. ayda başlayıp, 16. ayda % 65’e ve 24. ayda % 84’e ulaşmıştır. Ortalama ÖF alanı doğumdan 2. aya kadar artmış, 3-9 aylarda azalan dalgalı bir seyir göstermiş ve 9. aydan 2 yaşa kadar ise giderek azalmıştır. ÖF alanı ile subaraknoid mesafe genişliği arasında ilişki saptanmadı (r:0,229, p
Kennzahlenvergleich zwischen Flachland- und Gebirgsforstbetrieben in der DACH-Region
Authors: Bürgi Patric , Müller Alexandra , Sekot Walter , Toscani Philipp , Englert Hermann , Pauli Bernhard , Metzker Marietta 
Published: September 2022

Abstract
Die sogenannte DACH-Initiative verfolgt das Ziel, eine bessere Vergleichbarkeit zwischen den nationalen Datensätzen der forstlichen Testbetriebsnetze Deutschlands, Österreichs und der Schweiz herzuleiten und daraus Schlussfolgerungen für Politik, Wissenschaft und Praxis zu ziehen. Erste Vergleiche von Länderkennzahlen zeigen, dass die Auswirkungen der teilweise unterschiedlichen Rahmenbedingungen dargestellt werden können. Um die wirtschaftliche Leistungsfähigkeit der Forstbetriebe in der DACH-Region vertiefter zu untersuchen, wurden Kollektive von Flachland- und Gebirgsforstbetrieben betrachtet. Die Auswertungen zeigen, dass die Bildung von spezifischen Vergleichskollektiven eine differenziertere Analyse der wirtschaftlichen Situation der Forstbetriebe ermöglichen, da Betriebe mit ähnlichen Produktionsbedingungen verglichen werden. Der konkrete Kennzahlenvergleich für die Jahre 2015–2019 zeigt, dass die Entwicklungen im Flachland und Gebirge ähnlich sind, aber auf teilweise unterschiedlichem Niveau. Im Kerngeschäft der Forstbetriebe, der Waldbewirtschaftung, erzielen die deutschen und österreichischen Forstbetriebe über den Beobachtungszeitraum hinweg fast ausnahmslos einen Einnahmenüberschuss. In der Schweiz ist die Waldbewirtschaftung hingegen sowohl im Flachland als auch im Gebirge nicht kostendeckend – trotz im Vergleich zu Deutschland und Österreich umfangreichen Förderungen und Abgeltungen der öffentlichen Hand. Hauptgrund für die negativen Ergebnisse der Waldbewirtschaftung in der Schweiz ist die ungünstige Kostenstruktur insbesondere in der Holzernte, im Waldbau und in der Walderschliessung. Ursachen hierfür sind neben Unterschieden bei den Lohnkosten teils nicht auf die Betriebsverhältnisse angepasste Ressourcen, die zum Einsatz suboptimaler Verfahren führen.
GC-MS and LC-MS/MS Analysis of Bouea macrophylla Fruit Juice
Authors: Trifani Rina , Rabinowitz Oren , Abdillah Syamsudin , Sinaga Ernawati 
Published: September 2022

Bouea macrophylla Griff is a member of the Anacardiaceae family, which has edible fruits. Due to the high nutritional value, appealing taste, and attractive color, the fruit juice of B. macrophylla has the potential to be developed as a functional beverage. The present study was conducted to determine the phytochemical profile of B. macrophylla fruit juice using GC-MS and LC-MS/MS. GC-MS analysis was performed with the Agilent Technologies 7890 Gas Chromatograph with automated sampling and tandem Agilent 5975 Mass Selective Detector and peak analysis with the Chemistation data system. LC-MS/MS QTOF analysis was performed with UPLC Waters I Class and tandem MS/MS Xevo G2S QTOF with UNIFI software. GC-MS analysis identified five compounds with a quality match of 90% and above, namely 3-pentadecylphenol (31.68%), 5,5’-(oxybis(methylene)]-bis-2-furancarboxy-aldehyde (5.67%), 5-(hydroxymethyl)-2-furancarboxy-aldehyde (23.51%), 4H-pyran-4-one, 2,3-dihydro-3,5-dihydro-6-methyl (5.00%), and n-hexadecanoic acid (4.71%). Five major compounds were identified for the first time in B. macrophylla fruit juice by LC-MS/MS analysis, i.e., (E)-hexadecyl-ferulate, digupigan A, eburicoic acid, hydroginkgolinic acid, and terminalic acid. The health benefit of some of these detected phytochemicals supports the use of juice as the main ingredient for functional food.
Spherical Video-Based Virtual Reality (SVVR) Study: 360o-Video Implementation in English Learning Materials at Polytechnic Education
Authors: Rahmanu I Wayan Eka Dian , Lokman Altun  
Published: September 2022

On the horizon of English language learning, students incline to apply modern and contemporary media towards English language learning in Polytechnic education. The current learning tools dominantly apply the traditional technique, for example, PowerPoint, slides, and ordinary video which potentially mitigates learners’ spark in learning the lesson. Students in the Polytechnic State of Bali were analysed to provide the perception of Spherical Video-Based Virtual Reality (SVVR) through English language learning in the classroom. The theory of unified theory of acceptance and use of technology (UTAUT) was employed to measure the learners’ argument on these learning tools. The simple quantitative instruments were applied to analyse the data. The SVVR contribute to the students’ eagerness in learning the English language. Although the easiness of this tool enhances learners’ desire in the English language instructional, the necessity of high internet band-witch and access to run the SVVR in high resolution is encouraged.
Analysis of junior high school mathematics reasoning ability from multiple intelligence in hybrid learning
Authors: Zamani Wildan Azhar , Hendriana Benny 
Published: September 2022

Penelitian ini bertujuan untuk mendeskripsikan kemampuan penalaran matematis siswa SMPIT Raudhatul Jannah ditinjau dari multiple intelligence pada pembelajaran hybrid. Penelitian ini menggunakan metode kualitatif deskriptif. Subjek penelitian terdapat 3 siswa dari kelas 9E. Teknik pengumpulan data dengan metode tes soal kemampuan penalaran matematis, metode tes angket multiple intelligence, dan metode wawancara. Teknik analisis data yang digunakan dengan mereduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian yang diperoleh yaitu subjek yang memiliki kecerdasan visual-spatial dan kecerdasan linguistik memenuhi indikator analisis, generalisasi, dan sintesis. Pada indikator justifying dan penyelesaian persoalan non-rutin pada kecerdasan visual-spasial dan kecerdasan linguistik masih belum terpenuhi. Subjek yang memiliki kecerdasan logical-mathematical memenuhi indikator analisis, generalisasi, sintesis, dan penyelesaian persoalan non–rutin. Pada indikator justifying subjek yang memiliki kecerdasan logical-mathematical masih belum terpenuhi. Pada pembelajaran hybrid, logical mathematics intelligence lebih baik terhadap kemampuan penalaran matematis dibandingkan linguistic intelligence dan visual spatial intelligence.
Nanomaterials for biogas augmentation towards renewable and sustainable energy production: A critical review
Authors: Khan Sohaib Z. , Zaidi Asad A. , Naseer Muhammad Nihal , AlMohamadi Hamad 
Published: September 2022

Nanotechnology is considered one of the most significant advancements in science and technology over the last few decades. However, the contemporary use of nanomaterials in bioenergy production is very deficient. This study evaluates the application of nanomaterials for biogas production from different kinds of waste. A state-of-the-art comprehensive review is carried out to elaborate on the deployment of different categories of nano-additives (metal oxides, zero-valent metals, various compounds, carbon-based nanomaterials, nano-composites, and nano-ash) in several kinds of biodegradable waste, including cattle manure, wastewater sludge, municipal solid waste, lake sediments, and sanitary landfills. This study discusses the pros and cons of nano-additives on biogas production from the anaerobic digestion process. Several all-inclusive tables are presented to appraise the literature on different nanomaterials used for biogas production from biomass. Future perspectives to increase biogas production via nano-additives are presented, and the conclusion is drawn on the productivity of biogas based on various nanomaterials. A qualitative review of relevant literature published in the last 50 years is conducted using the bibliometric technique for the first time in literature. About 14,000 research articles are included in this analysis, indexed on the Web of Science. The analysis revealed that the last decade (2010–20) was the golden era for biogas literature, as 84.4% of total publications were published in this timeline. Moreover, it was observed that nanomaterials had revolutionized the field of anaerobic digestion, methane production, and waste activated sludge; and are currently the central pivot of the research community. The toxicity of nanomaterials adversely affects anaerobic bacteria; therefore, using bioactive nanomaterials is emerging as the best alternative. Conducting optimization studies by varying substrate and nanomaterials’ size, concentration and shape is still a field. Furthermore, collecting and disposing nanomaterials at the end of the anaerobic process is a critical environmental challenge to technology implementation that needs to be addressed before the nanomaterials assisted anaerobic process could pave its path to the large-scale industrial sector.
Machine-learned-based prediction of lower extremity overuse injuries using pressure plates
Authors: Nuyts Loren , De Brabandere Arne , Van Rossom Sam , Davis Jesse , Vanwanseele Benedicte 
Published: September 2022

Although running has many benefits for both the physical and mental health, it also involves the risk of injuries which results in negative physical, psychological and economical consequences. Those injuries are often linked to specific running biomechanical parameters such as the pressure pattern of the foot while running, and they could potentially be indicative for future injuries. Previous studies focus solely on some specific type of running injury and are often only applicable to a gender or running-experience specific population. The purpose of this study is, for both male and female, first-year students, (i) to predict the development of a lower extremity overuse injury in the next 6 months based on foot pressure measurements from a pressure plate and (ii) to identify the predictive loading features. For the first objective, we developed a machine learning pipeline that analyzes foot pressure measurements and predicts whether a lower extremity overuse injury is likely to occur with an AUC of 0.639 and a Brier score of 0.201. For the second objective, we found that the higher pressures exerted on the forefoot are the most predictive for lower extremity overuse injuries and that foot areas from both the lateral and the medial side are needed. Furthermore, there are two kinds of predictive features: the angle of the FFT coefficients and the coefficients of the autoregressive AR process. However, these features are not interpretable in terms of the running biomechanics, limiting its practical use for injury prevention.
Lateral annular systolic excursion ratio: A novel measurement of right ventricular systolic function by two-dimensional echocardiography
Authors: Stock Jonathan D. , Rothstein Eric S. , Friedman Scott E. , Gemignani Anthony S. , Costa Salvatore P. , Milbridge Andrew J. , Zhang Rui , Taub Cynthia C. , O'Rourke Daniel J. , Palac Robert T. 
Published: September 2022

IntroductionAccurate assessment of right ventricular (RV) systolic function has prognostic and therapeutic implications in many disease states. Echocardiography remains the most frequently deployed imaging modality for this purpose, but estimation of RV systolic function remains challenging. The purpose of this study was to evaluate the diagnostic performance of a novel measurement of RV systolic function called lateral annular systolic excursion ratio (LASER), which is the fractional shortening of the lateral tricuspid annulus to apex distance, compared to right ventricular ejection fraction (RVEF) derived by cardiac magnetic resonance imaging (CMR).MethodsA retrospective cohort of 78 consecutive patients who underwent clinically indicated CMR and transthoracic echocardiography within 30 days were identified from a database. Parameters of RV function measured included: tricuspid annular plane systolic excursion (TAPSE) by M-mode, tissue Doppler S', fractional area change (FAC) and LASER. These measurements were compared to RVEF derived by CMR using Pearson's correlation coefficients and receiver operating characteristic curves.ResultsLASER was measurable in 75 (96%) of patients within the cohort. Right ventricular systolic dysfunction, by CMR measurement, was present in 37% (n = 29) of the population. LASER has moderate positive correlation with RVEF (r = 0.54) which was similar to FAC (r = 0.56), S' (r = 0.49) and TAPSE (r = 0.37). Receiver operating characteristic curves demonstrated that LASER (AUC = 0.865) outperformed fractional area change (AUC = 0.767), tissue Doppler S' (AUC = 0.744) and TAPSE (AUC = 0.645). A cohort derived dichotomous cutoff of 0.2 for LASER was shown to provide optimal diagnostic characteristics (sensitivity of 75%, specificity of 87% and accuracy of 83%) for identifying abnormal RV function. LASER had the highest sensitivity, accuracy, positive and negative predictive values among the parameters studied in the cohort.ConclusionsWithin the study cohort, LASER was shown to have moderate positive correlation with RVEF derived by CMR and more favorable diagnostic performance for detecting RV systolic dysfunction compared to conventional echocardiographic parameters while being simple to obtain and less dependent on image quality than FAC and emerging techniques.
25-hydroxyvitamin D and testosterone levels association through body mass index: A cross-sectional study of young men with obesity
Authors: Damas-Fuentes Miguel , Boughanem Hatim , Molina-Vega María , Tinahones Francisco J. , Fernández-García José C. , Macías-González Manuel 
Published: September 2022

BackgroundsVitamin D and testosterone deficiency have been widely related to obesity. However, only a few studies have investigated the effect of vitamin D on testosterone in the context of obesity, in which controversial results have been raised.ObjectivesThe purpose of this study was to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and testosterone levels in young men with different grade of obesity.Design and methodsThis cross-sectional study included 269 healthy young men with obesity (body mass index (BMI) ≥ 30 kg/m2). Participants were divided into two groups based on their serum 25(OH)D levels (134 subjects with vitamin D sufficiency and 135 participants with vitamin D deficiency, according to the 50th percentile of 25(OH)D). Serum 25(OH)D and sex hormones have been measured. The relationships between 25(OH)D, sex hormones, and obesity grades were investigated with linear and binary logistic regression analyses, as well as mediation analysis.ResultsCompared to the 25(OH)D sufficiency group, total and free testosterone levels were found to be decreased, whereas serum androstenedione levels were increased in the 25(OH)D deficiency group (p&lt;0.05). Using multivariable lineal regression analyses, 25(OH)D was correlated with the majority of sex hormones (p&lt;0.05). When mediation with BMI was performed, the direct effect between 25(OH)D and sex hormones disappeared, and only the indirect effect via BMI remained (demonstrating the importance of BMI). Furthermore, after controlling for age and smoking status, we discovered that total testosterone and SHBG were both significantly associated with 25(OH)D (p&lt;0.05) in subjects with obesity type III. Using a mediation analysis, we discovered that BMI had a partial effect on the association between 25(OH)D and total testosterone levels in morbidly obese participants, indicating that a direct association between 25(OH)D and total testosterone levels, and that BMI partially mediated this association.ConclusionsSerum 25(OH)D is associated with total testosterone levels in only those subjects with morbid obesity, suggesting a specific benefit in severe cases of obesity. Additional research is needed to elucidate possible common mechanisms.
CASP6 predicts poor prognosis in glioma and correlates with tumor immune microenvironment
Authors: Guo Kai , Zhao Jiahui , Jin Qianxu , Yan Hongshan , Shi Yunpeng , Zhao Zongmao 
Published: September 2022

BackgroundGlioma is an aggressive tumor of the central nervous system. Caspase-6 (CASP6) plays a crucial role in cell pyroptosis and is a central protein involved in many cellular signaling pathways. However, the association between CASP6 and prognosis of glioma patients remains unclear.MethodsFour bioinformatic databases were analyzed to identify differentially expressed genes (DEGs) between glioma and healthy tissues. Eighty-one protein-coding pyroptosis-related genes (PRGs) were obtained from the GeneCards database. The pyroptosis-related DEGs (PRDEGs) were extracted from each dataset, and CASP6 was found to be aberrantly expressed in glioma. We then investigated the biological functions of CASP6 and the relationship between CASP6 expression and the tumor microenvironment and immunocyte infiltration. The half maximal inhibitory concentration of temozolomide and the response to immune checkpoint blockade in the high- and low-CASP6 expression groups were estimated using relevant bioinformatic algorithms. Quantitative real-time reverse transcription PCR and western blotting were carried out to confirm the different expression levels of CASP6 between human astrocytes and glioma cell lines (U251 and T98G). We determined the role of CASP6 in the tumorigenesis of glioma by knocking down CASP6 in U251 and T98G cell lines.ResultsWe found that CASP6 was overexpressed in glioma samples and in glioma cell lines. CASP6 expression in patients with glioma correlated negatively with overall survival. In addition, CASP6 expression correlated positively with the degree of glioma progression. Functional analysis indicated that CASP6 was primarily involved in the immune response and antigen processing and presentation. Patients with high CASP6 levels responded more favorably to temozolomide, while patients with low expression of CASP6 had a better response to immunotherapy. Finally, in vitro experiments showed that CASP6 knockdown inhibited glioma proliferation.ConclusionsThe pyroptosis-related gene CASP6 might represent a sensitive prognostic marker for patients with glioma and might predict their response of immunotherapy and temozolomide therapy. Our results might lead to more precise immunotherapeutic strategies for patients with glioma.