bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors
Authors: Jemli H. , Ouali U. , Madouri S. , Aissa A. , Jomli R. 
Published: September 2022

IntroductionSchizophrenia (SCZ) is a severe mental disorder that is among the leading causes of disability worldwide. Multiple sclerosis (MS) is a chronic inflammatory neurological disease with a major impact on the quality of life of young adults. Despite the distinct nature of these two disorders, research studies have identified similarities in underlying pathological mechanisms and risk factors.ObjectivesTo illustrate, through a case report, the central role of inflammation in schizophrenia and its relationship with multiple sclerosis.MethodsCase Report of a 31-year-old male patient with schizophrenia who has been diagnosed with multiple sclerosis.ResultsMr M. is a 31 year old patient who was diagnosed with schizophrenia at age 17. Between the ages of 25 and 27, the patient had two severe psychotic relapses each one requiring inpatient treatment. At that time, he experienced predominantly severe positive symptoms and persistent suicidality. He was initially prescribed amisulpride up to 600mg, followed by haloperidol up to 45mg daily. Due to poor clinical response, the patient was put on clozapine 400mg/d and has been stabilized since 2017, with outpatient checkups. The patient has reported vertigo and trouble walking in August 2021. He has been referred to the Neurology Department. Clinical, biological and imaging findings were highly suggestive of Multiple sclerosis and the patient has received short courses of intravenous corticosteroids.ConclusionsThis case report highlights the possible association between Multiple Sclerosis and schizophrenia. Further research is needed to clarify the role of inflammation in the central nervous system in schizophrenia and the overlap with Multiple Sclerosis.DisclosureNo significant relationships.
The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia
Authors: Rog J. , Dzikowski M. , Juchnowicz D. , Waszkiewicz N. , Zalewska A. , Maciejczyk M. , Karakula-Juchnowicz H. 
Published: September 2022

IntroductionSchizophrenia (SZ) is associated with changes in haematological parameters related to low-grade inflammation state and could be amplified via oxidative stress (OS) related mechanisms. Although studies confirm this relationship, the results could be cofounded by patients’ treatment.ObjectivesThe study aimed to assess the connection between venous blood count and OS in drug-naïve first-episode SZ patients.MethodsThe study consisted of 24 SZ drug-naïve patients during first episode of psychosis (median age: 22 years), and 31 healthy individuals (HC) as a control group (median age: 28 years). The examination included clinical data, OS parameters (enzymatic and non-enzymatic antioxidants), peripheral blood counts.ResultsWe did not find differences between SZ and HC in blood count parameters (p>0.05). In patients group, white blood cells (WBC), neutrophils and neutrophils-to-lymphocyte ratio (NLR) were positively related with the severity of positive symptoms (R=0.59, R=0.53, R=0.50; p<0.05, respectively). WBC was related to superoxide dismutase (SOD-1) levels (HC: R=-0.36, SZ: R=0.70; p<0.05). Neutrophils were positively related to catalase (CAT) (R=0.52; p<0.05) and ferric reducing antioxidant power (FRAP) (R=0.61; p<0.05), but only in the patients’ group. There was a positive relationship between NLR and CAT (R=0.45; p<0.05) in the SZ group.ConclusionsThe results indicate potential connection and interplay between OS and blood count parameters in the onset of psychotic episode. Further studies on a larger group of patients are needed.DisclosureNo significant relationships.
The effect of COVID-19 pandemic on admissions for cannabis-induced psychotic disorder
Authors: Elias De Sousa A. , Machado A.S. , Andrade F. , Roque Gonçalves M. , Vieira-Coelho M. 
Published: September 2022

IntroductionCannabis-induced psychotic disorder (CIPD) is defined by the development of psychotic symptoms during or briefly after intoxication with cannabis or withdrawal from cannabis. The social measures and restrictions implemented following the COVID-19 pandemic might have had an impact on cannabis availability, as suggested by patients from our clinical practice, reporting a shortage of the substance.ObjectivesTo compare sociodemographic, clinical characteristics and admission rates of inpatient treatment for cannabis-induced psychotic disorder in COVID-19 pandemic period and pre-pandemic period.Methods
Retrospective observational study of inpatient admissions for CIPD in a psychiatry inpatient unit of a tertiary hospital. The statistical analysis was performed using SPSS software, version 27.0.ResultsOur sample included 120 inpatient admissions, corresponding to 80 patients. Compared to 2018 and 2019, in 2020 there was an overall reduction of 21.5% in inpatient admissions (n=618, 549 and 458, respectively). The number of admissions for CIPD in 2018, 2019, 2020 and 2021 up to september were, respectively, 29, 32, 10 and 31 (5.2%, 6.1%, 2.2% and 7.2% of respective annual admissions). We found no statistically significant differences regarding sociodemographic and clinical characteristics in patients admitted for CIPD during 2020.ConclusionsThese results suggest a disproportionate reduction of inpatient admissions due to CIPD in 2020, followed by an expressive increase in the number of admissions in 2021up to september. This might be related to cannabis availability returning to regular levels. However other factors must be considered, such as the delay of treatment due to reduced accessibility to health care.DisclosureNo significant relationships.
Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study
Authors: Fernandes L.A. , Trancas B. , Maia T. , Borja Santos N. 
Published: September 2022

IntroductionKraepelin’s systematic paraphrenia (SP) has been historically used to identify a group of patients in the psychosis-spectrum with good global functioning and reduced impairment in volition and emotions.ObjectivesCross-sectional study comparing a group of patients with SP with another with schizophrenia (SZ).MethodsWe consecutively recruited SP cases from a single centre. SZ cases were selected to match those in the SP group in terms of age and sex. We diagnosed SP using the Munro Criteria and SZ using ICD-10. We collected standard sociodemographic and clinical data. All patients were under follow-up in a community mental health team at the time of the study. We used PANSS total score (PANSS-TS) to assess disease severity and its subscales to evaluate positive (PANSS-P) and negative (PANSS-N) symptoms, and general psychopathology (PANSS-GP). We applied SOFAS to assess social and occupational functioning.ResultsWe recruited 32 patients, 16 with a diagnosis of SP and 16 with a diagnosis of SZ. The two groups did not differ in terms of sociodemographic data. SP cases showed lower values for PANSS-TS (SP: mean=51.63±12.49; SZ=77.76±14.12; p<0.001), PANSS-NS (SP: mean=15.50±5.97; SZ: mean=26.06±5.39; p<0.001), and PANSS-GP (SP: mean=24.31±5.51; SZ: mean=37.13±5.62; p<0.001). Groups did not differ in terms of positive symptoms. SOFAS scores were significantly higher in SP (SP: median=68, interquartile range (IQR)=19; SZ: median=41, IQR=24; p<0.01). PNSS-NS negatively correlated with SOFAS only in the SP group (r=-0.716; p=0.002).ConclusionsSP differs from SZ in negative symptoms and social and occupational functioning. These findings suggest clinical features can differentiate SP from SZ.DisclosureNo significant relationships.
Folie à deux: contagious mental illness? Report of a clinical case
Authors: Costa A. , Jesus S. , Almeida M. , Alcafache J. 
Published: September 2022

IntroductionFolie à deux is a clinical condition that was first described in 19th century. It is a psychotic disorder in which two closely associated individuals share a similar delusional system. However, folie à deux is still a matter of study and debate today as it remains a challenge for psychiatrists.ObjectivesThe aim of this article is to report a clinical case of folie à deux, between na inducer son and an induced mother. Review the nosological significance of folie à deux and to explore the disorder among patients with psychosis.MethodsSearch in the PubMed/MedLine and Medscape databases with the following key words: folie à deux; shared psychosis; shared delusion.ResultsWe presente a case of folie à deux between na inducer son 28 years old and the induced, his mother. They were found to be sharing similiar delusional beliefs. The patient has assumed the role of “man of the house” since his father’s death.ConclusionsMany years after it was first described, folie à deux is still an interesting and challenging disorder to psychiatrists. Its recognition and correct referral for a rare diagnosis, such as folie a deux, are extremely important.DisclosureNo significant relationships.
Paliperidone palmitate-induced enuresis: a case report
Authors: Cruz S. , Cunha E Costa N. , Morais A. , Mendonça M. , Trindade R. , Xavier S. 
Published: September 2022

IntroductionSchizophrenia is a severe mental illness that requires long-term treatment with antipsychotics and the intramuscular (IM) long-acting injectable (LAI) formulations may enhance treatment adherence. Some antipsychotics have been associated with enuresis, including atypical antipsychotics such as risperidone(6.2%), quetiapine(6.7%), olanzapine (9.6% ) and clozapine (20.7%) [1]. Although oral paliperidone has been related to urinary incontinence, there is only 1 report of urinary incontinence linked to monthly paliperidone palmitate [2]. [1] Harrison-Woolrych, M., Skegg, K., Ashton, J., Herbison, P., Skegg, D.C., 2011. Nocturnal enuresis in patients taking clozapine, risperidone, olanzapine and quetiapine: comparative cohort study. British Journal of Psychiatry 199, 140–144. doi:10.1192/bjp.bp.110.087478 [2] Karslıoǧlu, E.H., Özalp, E., Çayköylü, A., 2016. Paliperidone Palmitate-induced Urinary Incontinence: A Case Report. Clinical Psychopharmacology and Neuroscience 14, 96–100. doi:10.9758/cpn.2016.14.1.96ObjectivesTo establish an association between paliperidone palmitate and enuresis.MethodsCase report and a narrative review of the literature.ResultsThe patient was a 25-year-old healthy man when he was diagnosed with schizophrenia. Doctors prescribed paliperidone palmitate (LAI) 200mg monthly and he started to complain of enuresis. He was clearly suffering with this unpleasant and embarrassing adverse effect so the LAI was reduced to 150mg. Enuresis remained, so it was prescribed oxybutynin 20 mg/day and the patient improved.ConclusionsWe reported a case in which enuresis is likely to be associated with high-dose paliperidone LAI (with no clinical evidence of an organic cause). To treat it, the most effective strategy was oxybutynin 20 mg/day. This case is also important to show the impact of this symptom, which is not actively investigated.DisclosureNo significant relationships.
Sexuality in the Muslim community during Ramadan
Authors: Sayari N. , Maamri A. , Hajri A. , Haoua R. , Zalila H. 
Published: September 2022

IntroductionRamadan is a holly month for Muslims. Able-bodied adults fast and abstain from sexual activities from dawn to sunset. These hasty lifestyle changes have a major impact on the sexual life of the Muslim community.ObjectivesTo assess the impact of Ramadan on sexual activity in a Tunisian community.MethodsA cross-sectional study was conducted among married Muslim volunteers in Tunisia. The data was collected with an anonymous self-completed questionnaire, one week before Ramadan (W-1) and the fourth week of Ramadan (W4).ResultsWe included 100 person in this study. The sample consisted of 59 females and 41 males. The average age was 40.3 years. During Ramadan, sexual intercourse happened more often on weekends (p=0.009) and mostly during the second part of the night (p ˂0.001). Data suggest a disturbed sex life with less satisfaction about sexual life compared to W-1 (p<0.05). Monthly sexual intercourse frequency dropped from 5.76 coitus/month on W-1 to 3.27 on W 4 (p<0.05) and Duration of sex from 9.45 minutes to 6.85 minutes (p˂0.001). Couples communicated less about sex (p=0.004). Sexual abstinence was more frequent (p=0.016). Preliminaries were less performed (P=0.01) and were shorter (p˂0.001).Oral sex was less frequent as well as some sexual positions: fellatio (p=0.01) and cunnilingus (p=0.002), sexual positions of Andromache (P=0.002), posterior vaginal (P˂0.001) and lateral (P=0.001). The participants used less pornography (p=0.007).ConclusionsThis study demonstrated the deleterious impact of the lifestyles changes in Ramadan on the sexual life. Better sexual and religious education is recommended to prevent sexual dysfunctions.DisclosureNo significant relationships.
Factors associated with changes in sexual behavior during Ramadan
Authors: Sayari N. , Maamri A. , Hajri A. , Haoua R. , Zalila H. 
Published: September 2022

IntroductionPrevious studies have shown that the month of Ramadan has a negative impact on the sexual life of fasters. Sexuality during Ramadan seems monotonous, rather poor, leaving little room for foreplay, sensuality and diversification of the sexual repertoire.ObjectivesTo examine the socio-demographic and religious factors associated with the change in the sexual lives of fastersMethodsA cross-sectional study was conducted among married Muslim volunteers in Tunisia. The data was collected with an anonymous self-completed questionnaire, one week before Ramadan (W-1) and the fourth week of Ramadan (W4).ResultsWe included 100 participants in this survey.The analytical study found a negative correlation between age and the frequency of coitus during Ramadan (r= -0.2, p= 0.04). The lenth of the marriage was associated with less communication about sexual satisfaction during Ramadan (P=0.01). Rural origin was associated with less tenderness (p=0.03) and shorter foreplay (p=0.03). Wearing the veil was associated with sexual abstinence in women during Ramadan (p=0.038) and not wearing it was associated with the cessation of oral sex (p=0.04). The practice of prayer was correlated to a lesser diversification of sexual positions (p=0.01) and to the withdrawal of certain sexual positions: posterior vaginal (p=0.01), lateral (p=0.02), Andromache (p=0.004).ConclusionsChanges in the expression of sexuality during Ramadan are not consistent with religious dictates. These findings suggest that the perception of sexuality and its practices are motivated by tradition and culture much more than religion.DisclosureNo significant relationships.
A Multidimensional Evaluation of Intimacy
Authors: Sears M. , Mcmahon L. , Crosby C. , Freihart B. , Meston C. 
Published: September 2022

IntroductionSupportive, nurturing relationships facilitate good health, well-being, and life satisfaction. Intimacy is crucial for developing successful relationships as it strengthens bonds between partners through the exchange of personal details, love, and affection. Despite the importance of intimacy in developing strong relationships, the extant research often conflates affection, trust, and sexual acts with intimacy or only considers one aspect of an intimate relationship (i.e., physical or sexual touch) .ObjectivesThe current study aimed to clarify what elicits feelings of intimacy in men and women in order to develop a more nuanced conceptualization of intimacy for use in future research and clinical practice.MethodsIn Study 1, women and men nominated over 2,700 items that “elicited feelings of intimacy” for them. Examples of nominations included: trust, communication, touch, attraction, and sex. Trained raters condensed duplicate items and created a final list of unique nominations for use in Study 2. Study 2 identified the factor structure of the nominated items by having a new sample of participants rate the extent each item elicited intimacy for them.ResultsData collection is ongoing but will be completed by December 2021. Results will be updated with an addendum after data analysis.Conclusionswill focus on gender differences in the factor structure of intimacy, how future research can avoid conflating this important construct with other relational aspects, and how a deeper understanding of intimacy can benefit treatment in clinical contexts and strengthen relationships more broadly.DisclosureNo significant relationships.
Chemsex, G&T, and The Club Drugs Clinic Ireland
Authors: Santlal K. , Fenton F. , Mccarron P. , Egbuta U. , Keenan E. 
Published: September 2022

IntroductionChemsex refers to the intentional consumption of specific substances, Gamma Hydroxybutyrate/Gamma Butyrolactone (GHB/GBL), Crystal Methamphetamine and/or Cocaine to facilitate or enhance the sexual experience. However, there was a plethora of associated problems ranging in severity to complex, life-threatening situations. Since its inception in 2014, The Club Drugs Clinic Ireland, the first outpatient-based clinic for GHB/GBL Detoxification in Ireland, had evolved to include managing problematic chemsex.ObjectivesThe Chemsex Working Group Ireland is a collaborative response from governmental and non-governmental agencies. Details of current medical and psychiatric management along with preliminary outcome findings on detoxification, relapse risk and associated factors will be presented.Methods

Data collected include socio-demographic variables, gender and sexuality, detoxification setting, relapse history and attendance for counselling or aftercare. Descriptive analyses were conducted on referral counts, drug trends, success of first treatment episode, subsequent relapse rate, and uptake of counselling and aftercare.ResultsThere have been over 200 referrals to the Club Drugs Clinic Ireland. A number of predisposing and precipitating factors, contributed to the relapse rate (up to 70%) both in Ireland and internationally. The salutogenic, biopsychosocial-based model of addiction recovery produced the best outcomes. This integrated Dual Diagnosis Psychiatry, Sexual Health Medicine, Emergency Medicine and external services for a more comprehensive care.ConclusionsThe pattern of referrals reflects population trends in chemsex, despite the COVID-19 restrictions. While detoxification is largely successful, the high relapse rate highlights the challenge of maintaining abstinence. In order to competently address problematic chemsex, service coordination across various medical professions and ongoing monitoring of the substances consumed is quintessential.DisclosureNo significant relationships.
Sexual functioning in patients with cancer
Authors: Guermazi A. , Hentati S. , Masmoudi R. , Guermazi F. , Baati I. , Feki I. , Masmoudi J. 
Published: September 2022

IntroductionSexuality is a growing field in the context of the management of chronic diseases and cancer in particular. Cancer treatments and the traumatic nature of the cancer experience frequently elicit considerable sexual difficulties.ObjectivesTo assess the prevalence of sexual dysfunction (SD) in patients with cancer, and to determine the associated factors.MethodsThis was a cross-sectional study, conducted over 1 month, involving 100 cancer patients followed in the oncology department at the Habib Bourguiba University Hospital in Sfax (Tunisia). General, clinical and therapeutic data were collected using a pre-established questionnaire. Sexual function was assessed with the “Female sexual Function Index” and the “International Index of Erectile Function”.ResultsThese results showed that half of the patients were female, and 70% of them were married. Their mean age was 51.96, and 68% of them were unemployed. Unemployment in men and treatment with chemotherapy were statistically associated with erectile dysfunction (p=0.049 and p= 0.001 respectively). treatment with radiotherapy was statistically associated with decreased desire in men (p=0.048). Depression correlated with a decreased orgasm (p=0.032) and erectile dysfunction (p=0.043) in men, mean score of IIEF (p= 0.019) and with a decreased sexual arousal (p=0.006) in women.ConclusionsSexual dysfunction is common in cancer patients. They can be of iatrogenic or psychological origin and can depend on the dynamics of the couple relationship. Training to raise awareness of the importance of sexuality first among cancer patients should be considered given the lack of communication between doctors and patients regarding sexuality issues.DisclosureNo significant relationships.
Sexual dysfunction and quality of life among Tunisian patients with schizophrenia
Authors: Guermazi A. , Smaoui N. , Jardak D. , Feki R. , Gassara I. , Omri S. , Maalej M. , Zouari L. , Ben Thabet J. , Charfi N. , Maalej M. 
Published: September 2022

IntroductionSexual dysfunction (SD) is prevalent among psychiatric patients than general population.ObjectivesTo assess the SD and quality of life (QOL) of patients with schizophrenia, and to identify the factors associated with it.MethodsThis was a cross-sectional, descriptive and analytical study, which began in December 2019, conducted with 60 subjects followed for SCZ or SAD, at the psychiatry outpatient unit of the Hédi Chaker University Hospital in Sfax (Tunisia). General, clinical and therapeutic data were collected using a pre-established questionnaire. The Arizona Sexual Experiences Scale (ASEX) and the 36 item Short-Form Health Survey (SF-36) were used to evaluate subjective sexual dysfunction and QOL respectively.ResultsPatients enrolled had SCZ in 78.2% and SAD in 21.8% of cases. The mean age was 47.2 years. Psychiatric family history, the presence of personal somatic illnesses and tobacco use were found in 43.6%, 61.8% and 67.3% of cases, respectively. The average score of ASEX was 18.21. QOL was altered in 73.3% of participants with an SGM of 53.29. The psychic component was more altered than the physical one with average scores estimated respectively at 48 and 58.44. Participants with SD were more likely to have tobacco consumption (p= 0.025), history of suicide attempt (p=0.023) and they are treated by a combination of several treatments (p=0.025). Impaired QOL was not statistically correlated with SD (p=0.5)ConclusionsThe physicians should pay attention to SD during the assessment and treatment of patients with schizophrenia.DisclosureNo significant relationships.