bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction
Authors: Gao Lilin , Zhang Shaojie , Wo Xuewen , Shen Xiangpeng , Tian Qiangyuan , Wang Guoqing 
Published: January 2022

Objectives: To compare the efficacy and safety of intravenous thrombolysis with alteplase and intravenous thrombolysis with urokinase for patients with acute cerebral infarction.
Methods: This prospective study included 140 patients with acute cerebral infarction who were admitted to our hospital between June 2018 and June 2019. They were randomly divided into two groups. The control group (70 cases) was treated with urokinase intravenous thrombolysis, and the observation group (70 cases) was given alteplase intravenous thrombolytic therapy. The treatment efficacy and safety of the two groups were compared.
Results: The total effective rate of the observation group was 95.7%, and that of the control group was 78.6%, i.e., the total effective rate of the observation group was significantly superior to the that of the control group (P < 0.05). After treatment, the observation group had significantly lower National Institutes of Health Stroke Scale (NIHSS) score and significantly higher mini-mental state examination (MMSE) score than the control group; the difference was statistically significant (P<0.05). After treatment, the levels of inflammatory factors of both groups significantly decreased compared to before treatment, and the decrease in the observation group was larger than that in the control group (P<0.05). The levels of serum homocysteine (Hcy) and monocyte chemoattractant protein-1 (MCP-1) in the observation group were significantly lower than those in the control group after treatment, and the differences were statistically significant (P<0.05). The incidence of hemorrhagic adverse reaction in the observation group was lower than that in the control group (P<0.05).
Conclusion: In the treatment of acute cerebral infarction, ccompared with urokinase, alteplase can further relieve cognitive impairment and promote the recovery of nerve function through inhibiting levels of inflammatory factors and levels of serum Hcy and MCP-1.
doi: https://doi.org/10.12669/pjms.38.3.4521
How to cite this:Gao L, Zhang S, Wo X, Shen X, Tian Q, Wang G. Intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4521
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Problems faced by patients and health service utilization experiences of gastrointestinal patients during lockdown due to COVID-19 pandemic
Authors: Kalwar Hamid Ali , Kamani Lubna 
Published: January 2022

Objectives: The COVID-19 pandemic undermined the health service delivery and utilization of essential health care services globally. The current study therefore aimed to explore the health-seeking behaviors and challenges faced by patients for the management of gastrointestinal diseases.
Methods: A cross-sectional study was conducted at the outpatient department of Gastroenterology, Liaquat National Hospital, Karachi from March 2020 to July 2020 during the COVID-19 lockdown phase to explore patient experiences. Data was collected using a survey questionnaire. All patients of either gender were included after informed consent. Statistical analysis of the data was conducted using SPSS 21.0.
Results: A total of 184 patients were included who visited the hospital to seek medical services during the COVID-19 lockdown phase. The mean age of the population was 42.7 years (±16.13). Of these, n=94 (51.1%) were males All patients had gastrointestinal issues with different comorbid conditions. One forty-seven n=147 (79.9%) presented with active complaints whereas, n=37 (20.1%) patients visited the hospital for their follow-up checkup. Out of 184 patients, n=33 (17.9%) patients reported of having fear of visiting hospital due to COVID-19 outbreak. A statistically significant difference p<0.001 was noted between the history of comorbidities and patient delaying a visit to the healthcare due to the fear of COVID-19. Additionally, 61 (73.5%) patients with co-morbidity faced difficulty in finding public transport (p=0.01). Nevertheless, n=171 (93.0%) patients expressed satisfaction with the services provided by the hospital during the lockdown phase.
Conclusion: Patients with gastrointestinal conditions were largely affected by lockdown largely due to fear of contacting COVID-19 disease and inaccessibility to the public transportation. Widely available telemedicine service might overcome these shortcomings and ensure continuity of quality care.
doi: https://doi.org/10.12669/pjms.38.3.4799
How to cite this:Kalwar HA, Kamani L. Problems faced by patients and health service utilization experiences of gastrointestinal patients during lockdown due to COVID-19 pandemic. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4799
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Optimal ablation index parameters for radiofrequency ablation therapy of atrial fibrillation
Authors: Qin Xiaoru , Jiang Xiaofei , Yuan Qiyan , Xu Guangli , He Xianzhi 
Published: January 2022

Objective: To explore the optimal ablation index (AI) parameters for radiofrequency catheter ablation (RA) for treating atrial fibrillation (AF).
Method: Patients with AF (186) who underwent bilateral PVAI in the Department of Cardiology, Zhuhai People’s Hospital, Guangdong Province, from March 2018 to October 2019 and received catheter ablation as first-round treatment, were grouped according to the received AI. Control group included patients (95) who received the recommended AI ablation (350–400 for posterior wall, 400–450 for non-posterior wall). Patients in optimal AI group were ablated with optimal AI (300–330 for posterior wall, 350–380 for non-posterior wall).
Results: Of 186 patients, 66 patients had paroxysmal atrial fibrillation and a mean CHA2DS2-VASc score of 2.83±1.64. Isolation rates of bilateral PVI in both groups were 91.4% and 93.6%, for patients with paroxysmal atrial fibrillation, and 81.7% and 80% for patients with persistent atrial fibrillation (P > 0.05). Left atrial function index (LAFI) decreased under the condition of sinus rhythm at the 3rd and 6th months (P < 0.05). LAFI improvement was significantly better in the optimal AI group than in the control group (P < 0.05). Rates of pain and cough during the ablation, and postoperative gastrointestinal discomfort and use of PPIs were higher in the control group (P < 0.05).
Conclusion: Radiofrequency ablation of AF, guided by optimal AI combined with impedance, can minimize atrial injury, prevent atrial failure, promote the recovery of atrial function, reduces intraoperative cough, pain, and postoperative gastrointestinal discomfort and use of PPIs.
doi: https://doi.org/10.12669/pjms.38.3.4971
How to cite this:Qin X, Jiang X, Yuan Q, Xu G, He X. Optimal ablation index parameters for radiofrequency ablation therapy of atrial fibrillation. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4971
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparing the diagnostic accuracy of computed tomography vs transoesophageal echocardiography for infective endocarditis − A meta-analysis
Authors: Jing Liqin , Song Yanchun 
Published: January 2022

Objective: To investigate the comparative diagnostic accuracy of cardiac computed tomography (CT) and transoesophageal echocardiography (TEE) for detecting infective endocarditis.
Methods: Original publications published in English language before July, 2021 were thoroughly search in PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), and Google Scholar literature databases. Studies were included if they used CT and/or TEE as an index test, presented data on valvular complications related to infective endocarditis, and used surgical findings as to the reference standard.
Results:­­­ Literature screening identified fifteen studies that fulfilled the inclusion criteria. Meta-analysis showed that CT sensitivity for detecting valvular abscesses was higher than that of TEE [0.88 (95% confidence interval [CI]: 0.82 to 0.94; 11 studies involving 842 subjects) versus 0.74 (95% CI: 0.65 to 0.84) P = 0.015; 12 studies involving 917 subjects]. TEE showed statistically significantly greater sensitivity than CT for detecting valvular vegetation [0.91 (95% CI: 0.84 to 0.97, 11 studies involving 971 subjects) versus 0.80 (95% CI: 0.69 to 0.82), 12 studies involving 915 subjects, P =0.019. In case of leaflet detection, TEE showed statistically significantly higher sensitivity than CT (0.76 vs 0.46, P =0.010).
Conclusion: CT performs statistically significantly better than TEE for detecting abscesses while TEE provides statistically significant superior results for detecting vegetation. There is a need for well-designed prospective studies to further corroborate these findings.
doi: https://doi.org/10.12669/pjms.38.3.5139
How to cite this:Jing L, Song Y. Comparing the diagnostic accuracy of computed tomography vs transoesophageal echocardiography for infective endocarditis − A meta-analysis . Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5139
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Need for including Hand Eye Coordination and Hand Function Training in the Management of Adhesive Capsulitis – A non-randomized control trial
Authors: Balu Senthil Kumar , Siva Subbaiah , Ramachandran Arunachalam 
Published: January 2022

Objectives: The objective of the study was to identify the effect of Maitland mobilization with hand-eye coordination and hand function exercises in the prognosis of adhesive capsulitis.
Methods: This non-randomized control trial was done with 40 patients with adhesive capsulitis referred to the OPD at UCA College of Physiotherapy, Chennai. The study was performed for 8 months duration from August 2018 to March 2019. After providing a sufficient explanation of the procedure, the patients were divided into Group-A and Group-B. Group-A were allocated to Maitland group (n=20) (MG) and Group-B, were assigned to the Maitland, Hand-eye coordination and Hand Function exercises group (n=20) (MHG), respectively. We measured Quality of life using SF36 to know whether these patients had poor QOL compared to normative. Each patient underwent testing before the experiment to evaluate the range of motion of the shoulder (Abduction and External rotation) measured using a 180º goniometer, Functional Disability assessed using SPADI index. Statistical analysis was applied using SPSS version 20.0. Before the study, data normality was tested. A parametric test was used to compare pre-and post-intervention data in each Group-And also compare the MG vs. MHG. An α < 0.05 is the level of significance in all analyses.
Results: A total of 40 subjects accounted for the study results. Their quality of life was significantly lower from the normative values. Both groups were homogenous at baseline with no significant difference between the ROM and SPADI scores. Both groups showed a significant improvement in ER, abduction ROM and SPADI scores, however the between group posttest analysis revealed that the Group-B subjects progressed significantly better.
Conclusions: The study concluded that the Maitland mobilization and hand-eye coordination and hand function exercises are an effective tool in improving shoulder abduction, external rotation and shoulder functions.
doi: https://doi.org/10.12669/pjms.38.3.5153
How to cite this:Senthil Kumar B, Subbaiah S, Ramachandran A. Need for including Hand Eye Coordination and Hand Function Training in the Management of Adhesive Capsulitis – A non-randomized control trial. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5153
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A new functional Hip Scoring System compatible with Asian Lifestyle
Authors: Junaid Javeria , Bhatti Anisuddin 
Published: January 2022

doi: https://doi.org/10.12669/pjms.38.3.5758
How to cite this:Junaid J, Bhatti A. A new functional Hip Scoring System compatible with Asian Lifestyle. Pak J Med Sci. 2022;38(3):442-444. doi: https://doi.org/10.12669/pjms.38.3.5758
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Morphofunctional changes in the rat's liver of different ages after L-methionine administration
Authors: Yanko Roman , Chaka Elena , Levashov Mikhail 
Published: January 2022

Background: Literature data on the effect of methionine on functional activity and, especially, on morphological changes in the liver parenchyma in animals of different ages are sporadic, and research results are often ambiguous.
Aim: The purpose of this work was to study and compare the morphofunctional changes in the liver of rats of different ages on prolonged administration of L-methionine.
Material and Methods: The experiment was performed on 48 male Wistar rats of 3 and 15 months of age. Animals of the experimental group received L-methionine at a dose of 250 mg/kg body weight in addition to the standard diet, daily for 21 days. Histological preparations were prepared from liver tissue by a standard technique. Morphometry was performed on digital images using the computer program «Image J». Succinate dehydrogenase activity and protein concentration were determined in the suspension of hepatocyte mitochondria.
Results: It was revealed that 21-day administration of L-methionine to rats led to hypertrophy of the hepatocyte nucleus, an increase in the nuclear-cytoplasmic ratio, the number of binuclear hepatocytes, and the nucleolus in the cell nucleus. The relative area of ​​the sinusoids network increased by 50% in 3-month-old animals. This indicated a better blood filling of the liver parenchyma. The increase in succinate dehydrogenase activity and protein concentration was revealed in the suspension of hepatocyte mitochondria of the experimental rats. This indicated an increase in the mitochondria energy potential and protein-synthetic activity.
Conclusions: The administration of prophylactic doses of methionine to healthy rats leads to the appearance of pronounced morphological and functional signs of increased activity of hepatocytes. The severity of this effect has a distinct age-dependent character. In young rats, it is more pronounced than in mature rats. The results of the study are important for practical medicine when using methionine for therapeutic and prophylactic purposes.
PENGEMBARAAN ILMIAH DAN PERAN SYEIKH AHMAD KHATIB AL-SYAMBASI DALAM PENYEBARAN ISLAM DI NUSANTARA MELALUI THARIQAT QADIRIYYAH WA NAQSABDNIYYAH
Authors: Farisi Salman Al 
Published: January 2022

Artikel ini berusaha menguraikan tokoh ulama Nusnatara yang termasuk ke dalam jaringan ulama Timur Tengah yang dikenal dengan Ashabul Jawawyn yakni Syeikh Ahmad Khatib al-Sambasi, yang memiliki peran yang sangat besar dalam penyebaran ajaran Islam, ia dikenal sebagai seorang yang ahli dalam bidang tasawuf dan disebut sebagai ahli Tsufi, ia juga dikenal sebagai pendiri tarekat Qadiriyyah wa Naqsabandiyyah[1]. Dalam mengumpulkan data, Penulis merujuk kepada refrensi yang berupa buku-buku, Jurnal, artikel, dan lain-lainnya yang relevan dengan tujuan pada penulisan artikel ini, dan setelah data terkumpul penulis, memilah serta memilih data yang dijadikan sebagai sumber refrensi kemudian menguraikan data yang didapatkan sesuai dengan tujuan dari artikel pada tulisan ini, ditemukan bahwa Syeikh Muhammad Ibn ‘Abd Ghaffar al-Sambasi adalah seorang ulama Nusantara yang berasal dari Kalimantan Barat yang mengembara mencari Ilmu Ke Negeri Haramyn pada usia 19 Tahun, dan menetap di Mekkah hingga ia Wafat pada tahun 1875 [2], walaupun demikian Syeikh Ahmad Khatib al-Syambasi dikenal sebagai seorang yang memiliki peran yang Besar dalam dunia Islam, khususnya beberapa wilayah Nusantara dan Melayu, diantara peran Syeikh Ahmad Khatib al-Sambasi ialah menyebarkan ajaran Islam melalui tarekat Qadiryyah wa Naqsabandiyyah, dengan mengacu kepada kitab yang dijadikan sebagai rujukan di dalam tarekat ini ialah kitab Fath al-‘Arifinkitab yang tulis oleh para muridnya melalui pendiktian langsung dari gurunya yakni Syeikh Ahmad Khatib al-Syambasi.[1] Said Aqil Siraj, Tasawuf Sebagai Kritik Sosial : Mengedepankan Islam Sebagai Inspirasi, Bukas Aspirasi, (Bandung : Mizan Pustaka, 2006), hlm. 426.[2] Muhammad Abdul Mujib dkk, Ensiklopedia Tasawuf Imam al-Ghazali, (Jakarta: Penerbit Hikmah, 2009),hlm.334.
GEOGRAPHICALLY WEIGHTED NEGATIVE BINOMIAL REGRESSION UNTUK MENANGANI OVERDISPERSI PADA JUMLAH PENDUDUK MISKIN
Authors: Delvia Nova , Mustafid Mustafid , Yasin Hasbi 
Published: January 2022

Poverty is a condition that is often associated with needs, difficulties an deficiencies in various life circumstances. The number of poor people in Indonesia increase in 2020. This research focus on modelling the number of poor people in Indonesia using Geographically Weighted Negative Binomial Regression (GWNBR) method. The number of poor people is count data, so analysis used to model the count data is poisson regression. If there is overdispersion, it can be overcome using negative binomial regression. Meanwhile to see the spatial effect, we can use the Geographically Weighted Negative Binomial Regression method. GWNBR uses a adaptive bisquare kernel for weighting function. GWNBR is better at modelling the number of poor people because it has the smallest AIC value than poisson regression and negative binomial regression. While the GWNBR method obtained 13 groups of province based on significant variables.
Physiological responses of Triplaris gardneriana Wedd. seedlings (Polygonaceae) under intermittent drought
Authors: Da Silva Elizamar Ciríaco , Aragão José Roberto Vieira , Bispo Iére Barros , Menezes Islayne da Cruz , Do Nascimento Hugo Henrique Costa 
Published: January 2022

Triplaris gardneriana Wedd is a deciduous riparian tree occurring in areas with different climatic conditions in Brazil, from the rainforest to the tropical dry forest. An increase in global temperature and drought events can change the growth pattern and establishment of the species. To evaluate the effects of intermittent drought on the growth of T. gardneriana seedlings, an experiment was performed using seedlings with one month old subjected to three water treatments (daily irrigation as control, and intermittent drought through cycles of water suppression of seven (S7) and 14 days-intervals (S14) between watering. Growth, biomass production and partitioning, relative water content (RWC), the accumulation of organic solutes, protoplasmic integrity and phenotypic plasticity index (PPI) were evaluated for a better understanding about its drought tolerance level. Intermittent drought severely affected plants growth in S14 plants, showing lower plant height, number of leaves, leaf area, and dry biomass. RWC was reduced, while carbohydrates and proline contents increased in response to drought stress. Protoplasmic damage increased electrolyte leakage in plants subjected to severe stress. However, T. garderiana demonstrated moderate tolerance to water deficit. The plastic changes observed were more physiological than morphological. Therefore, T. gardneriana seems to be a moderately tolerant species to intermittent drought.
Harmonic sections of vector bundles with spherically symmetric metrics
Authors: Abbassi Mohamed T. K. , Lakrini Ibrahim 
Published: January 2022

Abstract
We equip an arbitrary vector bundle over a Riemannian manifold, endowed with a fiber metric and a compatible connection, with a spherically symmetric metric (cf. [4]), and westudy harmonicity of its sections firstly as smooth maps and then as critical points of the energy functional with variations through smooth sections.We also characterize vertically harmonic sections. Finally, we give some examples of special vector bundles, recovering in some situations some classical harmonicity results.
Locally homogeneous non-gradient quasi-Einstein 3-manifolds
Authors: Lim Alice 
Published: January 2022

Abstract
In this paper, we classify the compact locally homogeneous non-gradient m-quasi Einstein 3- manifolds. Along the way, we also prove that given a compact quotient of a Lie group of any dimension that is m-quasi Einstein, the potential vector field X must be left invariant and Killing. We also classify the nontrivial m-quasi Einstein metrics that are a compact quotient of the product of two Einstein metrics. We also show that S1 is the only compact manifold of any dimension which admits a metric which is nontrivially m-quasi Einstein and Einstein.
Singular quasilinear convective elliptic systems in ℝ
N
Authors: Guarnotta Umberto , Marano Salvatore Angelo , Moussaoui Abdelkrim 
Published: January 2022

Abstract
The existence of a positive entire weak solution to a singular quasi-linear elliptic system with convection terms is established, chiefly through perturbation techniques, fixed point arguments, and a priori estimates. Some regularity results are then employed to show that the obtained solution is actually strong.
The application of neural network algorithm and embedded system in computer distance teach system
Authors: Qiu Qin 
Published: January 2022

Abstract
The computer distance teaching system teaches through the network, and there is no entrance threshold. Any student who is willing to study can log in to the network computer distance teaching system for study at any free time. Neural network has a strong self-learning ability and is an important part of artificial intelligence research. Based on this study, a neural network-embedded architecture based on shared memory and bus structure is proposed. By looking for an alternative method of exp function to improve the speed of radial basis function algorithm, and then by analyzing the judgment conditions in the main loop during the algorithm process, these judgment conditions are modified conditionally to reduce the calculation scale, which can double the speed of the algorithm. Finally, this article verifies the function, performance, and interface of the computer distance education system.