bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report: invasive ductal carcinoma in mosaic Li-Fraumeni syndrome
Authors: Wenger Danielle , Kurumety Sasha , Aydi Zeynep B 
Published: September 2022

Abstract
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant condition caused by pathogenic variants in the TP53 tumor suppressor gene and characterized by a high lifetime risk of various cancers with a very early age of onset. We are presenting a 41-year-old woman with right invasive ductal cancer and no family history of cancers, diagnosed with mosaic LFS confirmed with blood and skin punch biopsy samples. She was treated with neoadjuvant chemotherapy, mastectomy and sentinel node biopsy with completion axillary dissection. Adjuvant radiation was not recommended due to increased risk of secondary cancers. She also elected to undergo risk reducing contralateral mastectomy. Further research is warranted to determine the appropriate clinical management and surveillance strategies in patients with mosaic LFS as whether individuals with mosaic LFS have differing cancer risks in comparison to classic germline LFS is unknown.
The rare case of oesophago-pericardial fistula secondary to pulmonary tuberculosis
Authors: Sidhu Kavina Kaur , Seyfi Doruk , Lau Ngee Soon , Yeo David Andrew 
Published: September 2022

Abstract
We report the case of a healthy 35-year-old male with two rare pathologies: pneumopericardium and oesophago-pericardial fistula (OPF) secondary to tuberculosis. Purulent pericarditis and cardiac tamponade are known complications with potential for significant morbidity and mortality. Unfortunately, the symptoms of OPF are non-specific often delaying diagnosis. There is no gold standard for treatment or determinant of when nonsurgical versus surgical approach should be considered. Anti-tuberculous therapy alone is often adequate however an oesophageal stent was utilized in this case to rapidly gain control of the fistula and prevent ongoing contamination from mediastinitis.
Sex Education, Songs, and Spiritual Guidance: An Eighteenth-Century Servants’ Library
Authors: Bigold Melanie 
Published: September 2022

Abstract
This article brings to light a record for the largest known servants’ library of the eighteenth century. Found in a manuscript list in the hand of Elizabeth Percy, duchess of Northumberland (1715–1776), a keen collector and cataloguer of books, it comprises 131 titles. The list reinforces what we know about increased book use among the lower classes, particularly servants, but also provides new evidence of specific titles and, by extension, genres and formats of the books. Numerous chapbooks of prose-fiction, songs, and jests exist alongside evangelical tomes and pedagogical works. While the list cannot inform us about the extent of reading or use in the Northumberland household, the titles and genre statistics offer new insights, as well as some surprising anomalies.
Attributing Authorship to Bodleian MS Douce 171: A Seventeenth-Century Comedy by Arthur Wilson
Authors: Blank Daniel 
Published: September 2022

Abstract
This article argues that the anonymous dramatic fragment at the end of Bodleian Library, MS Douce 171, recently catalogued as ‘Comedy of Stella and Alexis’, is an authorial draft written by the seventeenth-century playwright Arthur Wilson (1595–1652). It does so through a careful consideration of the manuscript’s bibliographic features, as well as through palaeographical and stylistic comparison to Wilson’s extant plays and other documents in his hand. While scholars have long recognized the play’s existence, they have overlooked the identity of its author, in large part due to a neglect of the archival context in which the manuscript appears. This article not only assigns the play to a known early-modern dramatist, but also offers an exercise in attributing authorship to a theatrical document that gives very few hints about its origins.
New Fragments of Unrecorded Early English Printed Texts
Authors: Freeman Arthur , Freeman Janet Ing 
Published: September 2022

Abstract
This note is a supplement to a two-part article that appeared in The Library in 2008 on the collecting and identification of early English printed fragments and their use in the establishment of literary texts. A few fragments that have come to light since that time are discussed, including a portion of a unique ‘complaint of Christ’ titled Balade of Grevous is My Sorowe (c. 1530); damaged leaves of the farcical interlude Gammer Gurton’s Needle (1575) and of Ulpian Fulwell’s morality Like Will to Like (a previously unknown edition that must fall between what are now considered the second and third editions, c. 1586-87); and a scrap that preserves portions of eight pages from a hitherto unrecorded edition of The Hundred Merry Tales, generally known as ‘Shakespeare’s jestbook’ (c. 1594 or later), a survival that has allowed a new look at the changing text of this early-modern best seller.
Vector dark boson mediated feeble interaction between fermionic dark matter and strange quark matter in quark stars
Authors: Sen Debashree , Guha Atanu 
Published: September 2022

Abstract
We study the structural properties like the gravitational mass, radius, and tidal deformability of dark matter (DM) admixed strange quark stars (SQSs). For the purpose we consider the vector MIT Bag model to describe the strange quark matter (SQM) and investigate the possible presence of accreted DM in the SQSs consequently forming DM admixed SQSs. We introduce feeble interaction between SQM and the accreted fermionic DM via a vector dark boson mediator. Considering the present literature, in the context of possible presence of DM in SQSs, this work is the first to consider interaction between DM and SQM in the DM admixed SQSs. The mass of the DM fermion (mχ) and the vector mediator (mξ) and the coupling (yξ) between them are determined in accordance with the constraint from Bullet cluster and the present day relic abundance, respectively. We find that the presence of DM reduces both the mass and radius of the star compared to the no-DM case. The massive the DM fermion, the lower the values of maximum mass and radius of the DM admixed SQSs. For the chosen values of mχ and corresponding values of mξ and yξ, the computed structural properties of the DM admixed SQSs satisfy all the various present day astrophysical constraints. We obtain massive DM admixed SQSs configurations consistent with the GW190814 observational data. Hence the secondary compact object associated with this event may be a DM admixed SQS.
The phenomenology of the external field effect in cold dark matter models
Authors: Paranjape Aseem , Sheth Ravi K 
Published: September 2022

ABSTRACT
In general relativity (GR), the internal dynamics of a self-gravitating system under free-fall in an external gravitational field should not depend on the external field strength. Recent work has claimed a statistical detection of an ‘external field effect’ (EFE) using galaxy rotation curve data. We show that large uncertainties in rotation curve analyses and inaccuracies in published simulation-based external field estimates compromise the significance of the claimed EFE detection. We further show analytically that a qualitatively similar statistical signal is, in fact, expected in a Λ-cold dark matter (ΛCDM) universe without any violation of the strong equivalence principle. Rather, such a signal arises simply because of the inherent correlations between galaxy clustering strength and intrinsic galaxy properties. We explicitly demonstrate the effect in a baryonified mock catalogue of a ΛCDM universe. Although the detection of an EFE-like signal is not, by itself, evidence for physics beyond GR, our work shows that the sign of the EFE-like correlation between the external field strength and the shape of the radial acceleration relation can be used to probe new physics: e.g. in MOND, the predicted sign is opposite to that in our ΛCDM mocks.
Correlated variability of the reflection fraction with the X-ray flux and spectral index for Mrk 478
Authors: Barua Samuzal , Jithesh V , Misra Ranjeev , Medhi Biman J , Adegoke Oluwashina 
Published: September 2022

ABSTRACT
The X-ray spectrum of Mrk 478 is known to be dominated by a strong soft excess that can be described using relativistic blurred reflection. Using observations from XMM–Newton, AstroSat, and Swift, we show that for the long-term (∼years) and intermediate-term (days to months) variability, the reflection fraction is anticorrelated with the flux and spectral index, which implies that the variability is due to the hard X-ray producing corona moving closer to and further from the black hole. Using flux-resolved spectroscopy of the XMM–Newton data, we show that the reflection fraction has the same behaviour with flux and index on short time-scales of hours. The results indicate that both the long- and short-term variability of the source is determined by the same physical mechanism of strong gravitational light bending causing enhanced reflection and low flux as the corona moves closer to the black hole.
Phase diagrams of binary ionic mixtures and white dwarf cooling
Authors: Baiko D A 
Published: September 2022

ABSTRACT
Phase diagrams of fully ionized binary ionic mixtures are considered within the framework of the linear mixing formalism taking into account recent advances in understanding quantum one-component plasma thermodynamics. We have followed a transformation of azeotropic phase diagrams into peritectic and eutectic types with increase of the charge ratio. For solid 12C/16O and 16O/20Ne mixtures, we have found extensive miscibility gaps. Their appearance seems to be a robust feature of the theory. The gaps evolve naturally into two-solid regions of eutectic phase diagrams at higher Z2/Z1. They do not depend on thermodynamic fit extensions beyond their applicability limits. The gaps are sensitive to binary mixture composition and physics, being strongly different for C/O and O/Ne mixtures and for the three variants of corrections to linear-mixing solid-state energies available in the literature. When matter cools to its miscibility gap temperature, the exsolution process takes place. It results in a separation of heavier and lighter solid solutions. This may represent a significant reservoir of gravitational energy and should be included in future white dwarf (WD) cooling simulations. Ion quantum effects mostly resulted in moderate modifications; however, for certain Z2/Z1, these effects can produce qualitative restructuring of the phase diagram. This may be important for the model with 22Ne distillation in cooling C/O/Ne WD proposed as a solution for the ultramassive WD cooling anomaly.
A semi-analytical model for the formation and evolution of radio relics in galaxy clusters
Authors: Zhou Yihao , Xu Haiguang , Zhu Zhenghao , Zhao Yuanyuan , Fan Shida , Shan Chenxi , Zhu Yongkai , Hao Lei , Ji Li , Zhang Zhongli , Zheng Xianzhong 
Published: September 2022

ABSTRACT
Radio relics are Mpc-sized synchrotron sources located in the peripheral regions of galaxy clusters. Models based on the diffuse shock acceleration (DSA) scenario have been widely accepted to explain the formation of radio relics. However, a critical challenge to these models is that most observed shocks seem too weak to generate detectable emission, unless fossil electrons, a population of mildly energetic electrons that have been accelerated previously, are included in the models. To address this issue, we present a new semi-analytical model to describe the formation and evolution of radio relics by incorporating fossil relativistic electrons into DSA theory, which is constrained by a sample of 14 observed relics, and employ the Press–Schechter formalism to simulate the relics in a 20° × 20° sky field at 50, 158, and 1400 MHz, respectively. Results show that fossil electrons contribute significantly to the radio emission, which can generate radiation four orders of magnitude brighter than that solely produced by thermal electrons at 158 MHz, and the power distribution of our simulated radio relic catalogue can reconcile the observed P1400–Mvir relation. We predict that $7.1{{\ \rm per\ cent}}$ clusters with $M_{\mathrm{vir}} \gt 1.2\times 10^{14}\, \mathrm{M}_{\odot }$ would host relics at 158 MHz, which is consistent with the result of $10 \pm 6{{\ \rm per\ cent}}$ given by the Second Data Release of the LOFAR Two-meter Sky Survey. It is also found that radio relics are expected to cause severe foreground contamination in future epoch of reionization experiments, similar to that of radio haloes. The possibility of active galactic nuclei (AGNs) providing seed fossil relativistic electrons is evaluated by calculating the number of radio-loud AGNs that a shock is expected to encounter during its propagation.
Stellar Populations in type Ia supernova host galaxies at intermediate-high redshift: Star formation and metallicity enrichment histories
Authors: Millán-Irigoyen I , del Valle-Espinosa M G , Fernández-Aranda R , Galbany L , Gomes J M , Moreno-Raya M , López-Sánchez Á R , Mollá M 
Published: September 2022

ABSTRACT
We present a summary of our project that studies galaxies hosting type Ia supernova (SN Ia) at different redshifts. We present Gran Telescopio de Canarias (GTC) optical spectroscopy of six SN Ia host galaxies at redshift z ∼ 0.4–0.5. They are joined to a set of SN Ia host galaxies at intermediate-high redshift, which include galaxies from surveys SDSS and COSMOS. The final sample, after a selection of galaxy spectra in terms of signal-to-noise and other characteristics, consists of 680 galaxies with redshift in the range 0.04 &lt; z &lt; 1. We perform an inverse stellar population synthesis with the code fado to estimate the star formation and enrichment histories of this set of galaxies, simultaneously obtaining their mean stellar age and metallicity and stellar mass. After analysing the correlations among these characteristics, we look for possible dependencies of the Hubble diagram residuals and supernova features (luminosity, colour and strength parameter) on these stellar parameters. We find that the Hubble residuals show a clear dependence on the stellar metallicity weighted by mass with a slope of −0.061 mag dex−1, when represented in logarithmic scale, log 〈ZM/Z⊙〉. This result supports our previous findings obtained from gas oxygen abundances for local and SDSS-survey galaxies. Comparing with other works from the literature that also use the stellar metallicity, we find a similar value, but with more precision and a better significance (2.08 versus ∼ 1.1), due to the higher number of objects and wider range of redshift of our sample.
Star-spots and magnetism: testing the activity paradigm in the Pleiades and M67
Authors: Cao Lyra , Pinsonneault Marc H 
Published: September 2022

ABSTRACT
We measure star-spot filling fractions for 240 stars in the Pleiades and M67 open star clusters using APOGEE high-resolution H-band spectra. For this work, we developed a modified spectroscopic pipeline which solves for star-spot filling fraction and star-spot temperature contrast. We exclude binary stars, finding that the large majority of binaries in these clusters (80 per cent) can be identified from Gaia DR3 and APOGEE criteria – important for field star applications. Our data agree well with independent activity proxies, indicating that this technique recovers real star-spot signals. In the Pleiades, filling fractions saturate at a mean level of 0.248 ± 0.005 for active stars with a decline at slower rotation; we present fitting functions as a function of Rossby number. In M67, we recover low mean filling fractions of 0.030 ± 0.008 and 0.003 ± 0.002 for main sequence GK stars and evolved red giants, respectively, confirming that the technique does not produce spurious spot signals in inactive stars. Star-spots also modify the derived spectroscopic effective temperatures and convective overturn time-scales. Effective temperatures for active stars are offset from inactive ones by −109 ± 11 K, in agreement with the Pecaut & Mamajek empirical scale. Star-spot filling fractions at the level measured in active stars changes their inferred overturn time-scale, which biases the derived threshold for saturation. Finally, we identify a population of stars statistically discrepant from mean activity–Rossby relations and present evidence that these are genuine departures from a Rossby scaling. Our technique is applicable to the full APOGEE catalogue, with broad applications to stellar, galactic, and exoplanetary astrophysics.
Ammonia in the interstellar medium of a starbursting disc at z = 2.6
Authors: Doherty M J , Geach J E , Ivison R J , Menten K M , Jacob A M , Forbrich J , Dye S 
Published: September 2022

ABSTRACT
We report the detection of the ground state rotational emission of ammonia, ortho-NH3 (JK = 10 → 00) in a gravitationally lensed intrinsically hyperluminous star-bursting galaxy at z = 2.6. The integrated line profile is consistent with other molecular and atomic emission lines which have resolved kinematics well modelled by a 5 kpc-diameter rotating disc. This implies that the gas responsible for NH3 emission is broadly tracing the global molecular reservoir, but likely distributed in pockets of high density (n ≳ 5 × 104 cm−3). With a luminosity of 2.8 × 106 L⊙, the NH3 emission represents 2.5 × 10−7 of the total infrared luminosity of the galaxy, comparable to the ratio observed in the Kleinmann–Low nebula in Orion and consistent with sites of massive star formation in the Milky Way. If $L_{\rm NH_3}/L_{\rm IR}$ serves as a proxy for the ‘mode’ of star formation, this hints that the nature of star formation in extreme starbursts in the early Universe is similar to that of Galactic star-forming regions, with a large fraction of the cold interstellar medium in this state, plausibly driven by a storm of violent disc instabilities in the gas-dominated disc. This supports the ‘full of Orions’ picture of star formation in the most extreme galaxies seen close to the peak epoch of stellar mass assembly.
Chloroquine disrupts zinc storage granules in primary Malpighian tubule cells of Drosophila melanogaster
Authors: Campos-Blázquez Jessica P , Schuth Nils , Garay Erika , Clark Adam H , Vogelsang Urs , Nachtegaal Maarten , Contreras Rubén G , Quintanar Liliana , Missirlis Fanis 
Published: September 2022

Abstract
Contrasting reports exist in the literature regarding the effect of chloroquine treatment on cellular zinc uptake or secretion. Here, we tested the effect of chloroquine administration in the Drosophila model organism. We show that larvae grown on a diet supplemented with 2.5 mg/ml chloroquine lose up to 50% of their stored zinc and around 10% of their total potassium content. This defect in chloroquine-treated animals correlates with the appearance of abnormal autophagolysosomes in the principal cells of the Malpighian tubules, where zinc storage granules reside. We further show that the reported increase of Fluozin-3 fluorescence following treatment of cells with 300 μM chloroquine for 1 h may not reflect increased zinc accumulation, since a similar treatment in Madin–Darby canine kidney cells results in a 36% decrease in their total zinc content. Thus, chloroquine should not be considered a zinc ionophore. Zinc supplementation plus chloroquine treatment restored zinc content both in vivo and in vitro, without correcting autophagic or other ionic alterations, notably in potassium, associated with the chloroquine treatment. We suggest that chloroquine or hydroxychloroquine administration to patients could reduce intracellular zinc storage pools and be part of the drug's mechanism of action.
Cell Taxonomy: a curated repository of cell types with multifaceted characterization
Authors: Jiang Shuai , Qian Qiheng , Zhu Tongtong , Zong Wenting , Shang Yunfei , Jin Tong , Zhang Yuansheng , Chen Ming , Wu Zishan , Chu Yuan , Zhang Rongqin , Luo Sicheng , Jing Wei , Zou Dong , Bao Yiming , Xiao Jingfa , Zhang Zhang 
Published: September 2022

Abstract
Single-cell studies have delineated cellular diversity and uncovered increasing numbers of previously uncharacterized cell types in complex tissues. Thus, synthesizing growing knowledge of cellular characteristics is critical for dissecting cellular heterogeneity, developmental processes and tumorigenesis at single-cell resolution. Here, we present Cell Taxonomy (https://ngdc.cncb.ac.cn/celltaxonomy), a comprehensive and curated repository of cell types and associated cell markers encompassing a wide range of species, tissues and conditions. Combined with literature curation and data integration, the current version of Cell Taxonomy establishes a well-structured taxonomy for 3,143 cell types and houses a comprehensive collection of 26,613 associated cell markers in 257 conditions and 387 tissues across 34 species. Based on 4,299 publications and single-cell transcriptomic profiles of ∼3.5 million cells, Cell Taxonomy features multifaceted characterization for cell types and cell markers, involving quality assessment of cell markers and cell clusters, cross-species comparison, cell composition of tissues and cellular similarity based on markers. Taken together, Cell Taxonomy represents a fundamentally useful reference to systematically and accurately characterize cell types and thus lays an important foundation for deeply understanding and exploring cellular biology in diverse species.
A ‘Moore's law’ for fibers enables intelligent fabrics
Authors: Qian Shengtai , Liu Mingyang , Dou Yuhai , Fink Yoel , Yan Wei 
Published: September 2022

ABSTRACT
Fabrics are an indispensable part of our everyday life. They provide us with protection, offer privacy and form an intimate expression of ourselves through their esthetics. Imparting functionality at the fiber level represents an intriguing path toward innovative fabrics with a hitherto unparalleled functionality and value. The fiber technology based on thermal drawing of a preform, which is identical in its materials and geometry to the final fiber, has emerged as a powerful platform for the production of exquisite fibers with prerequisite composition, geometric complexity and control over feature size. A ‘Moore's law’ for fibers is emerging, delivering higher forms of function that are important for a broad spectrum of practical applications in healthcare, sports, robotics, space exploration, etc. In this review, we survey progress in thermally drawn fibers and devices, and discuss their relevance to ‘smart’ fabrics. A new generation of fabrics that can see, hear and speak, sense, communicate, harvest and store energy, as well as store and process data is anticipated. We conclude with a critical analysis of existing challenges and opportunities currently faced by thermally drawn fibers and fabrics that are expected to become sophisticated platforms delivering value-added services for our society.