bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant chemotherapy and radical cystectomy in patients with bladder cancer
Authors: Karyakin O. B. , Vorobyov N. V. , Zaborskiy I. N. , Muradyan A. G. , Safiullin K. N. , Taraki I. A. , Demyashkin G. A. , Ivanov S. A. , Kaprin A. D. 
Published: December 2022

Background. Bladder cancer is the ninth most common malignant neoplasm worldwide. Hidden metastases at the time of diagnosis are the main reason muscle-invasive bladder cancer has poor prognosis. Even after radical cystectomy, muscleinvasive bladder cancer mostly progresses within 2 years with a recurrence rate of over 50 %. At stages II–IV of the disease, drug treatment is indicated before radical cystectomy. The main goal of neoadjuvant chemotherapy is to affect micrometastases, which may be present at the beginning of disease development. The response to ongoing chemotherapy can serve as a predictor of long-term survival.Aim. To increase effectiveness of bladder cancer treatment.Materials and methods. A total of 231 patients with bladder cancer were included in the study. The main contingent consisted of men over 60 years old with locally advanced tumors at stage Т2–Т4. Drug therapy was carried out in neoadjuvant mode before surgical treatment. Standard regimens were used: cisplatin + gemcitabine and MVAC (methotrexate, vinblastine, adriamycin, cisplatin). After four courses of neoadjuvant chemotherapy, the results were evaluated. With complete normalization of a patient’s condition, the issue of surgical treatment – radical cystectomy with one of the types of urinary diversion – was decided.Results and conclusion. The follow-up period for patients after treatment was 62 months. In patients who underwent neoadjuvant chemotherapy, the median overall survival was 44.9 months, in patients without neoadjuvant treatment – 36.8 months with improvement in recurrence-free survival from 32.5 to 39.8 months (p = 0.08). Overall survival after neoadjuvant chemotherapy improved by 8.1 months (p = 0.09).
Spectral analysis of cough sounds of patients with COVID-19
Authors: Budnevsky A. V. , Avdeev S. N. , Ovsyannikov E. S. , Feygelman S. N. , Choporov O. N. , Maximov A. V. , Pertsev A. V. 
Published: December 2022

Cough is a frequent manifestation of COVID-19 (COronaVIrus Disease 2019), therefore, it has an important diagnostic value. There is little information about the characteristics of cough of COVID-19 patients in the literature. To perform a spectral analysis of cough sounds in COVID-19 patients in comparison with induced cough of healthy individuals. Methods. The main group consisted of 218 COVID-19 patients (48.56% – men, 51.44% – women, average age 40.2 (32.4; 50.1) years). The comparison group consisted of 60 healthy individuals (50.0% men, 50.0% women, average age 41.7 (31.2; 53.0) years) who were induced to cough. Each subject had a cough sound recorded, followed by digital processing using a fast Fourier transform algorithm. The temporal-frequency parameters of cough sounds were evaluated: duration (ms), the ratio of the energy of low and medium frequencies (60 – 600 Hz) to the energy of high frequencies (600 – 6 000 Hz), the frequency of the maximum sound energy (Hz). These parameters were determined in relation to both the entire cough and individual phases of the cough sound. Results. Significant differences were found between some cough parameters in the main group and in the comparison group. The total duration of the coughing act was significantly shorter in patients with COVID-19, in contrast to the induced cough of healthy individuals (T = 342.5 (277.0; 394.0) – in the main group; T (c) = 400.5 (359.0; 457.0) – in the comparison group; p = 0.0000). In addition, it was found that the cough sounds of COVID-19 patients are dominated by the energy of higher frequencies as compared to the healthy controls (Q = 0.3095 (0.223; 0.454) – in the main group; Q (c) = 0.4535 (0.3725; 0.619) – in the comparison group; p = 0.0000). The maximum frequency of cough sound energy in the main group was significantly higher than in the comparison group (Fmax = 463.0 (274.0; 761.0) – in the main group; Fmax = 347 (253.0; 488.0) – in the comparison group; p = 0.0013). At the same time, there were no differences between the frequencies of the maximum energy of cough sound of the individual phases of cough act and the duration of the first phase. Conclusion. The cough of patients with COVID-19 is characterized by a shorter duration and a predominance of high-frequency energy compared to the induced cough of healthy individuals.
Prediction of Quality of Life Using Dermatology Life Quality Index in Iranian Patients with Neurofibromatosis Type 1
Authors: Foji Samira , Sanagoo Akram , Sharif Nia Seyed Hamid , Jouybari Leila 
Published: December 2022

Background: Neurofibromatosis type 1 (NF1), a genetic condition most commonly characterized by the presence of dermal neurofibromas and café au lait macules, has a significant impact upon the Quality of Life (QoL). The purpose of this study is to predict the QoL with Dermatology Life Quality Index (DLQI) in Iranian patients with neurofibromatosis type .1
Methods: This cross-sectional study was conducted on 223 patients with neurofibromatosis type 1 using available sampling. Data collection tools were demographic information form, SF-36 and DLQI questionnaires. Quality of life was predicted by DLQI. Linear and multiple regression tests were utilized to analyze the data.
Results: Predicting the quality of life by dermatology quality of life showed that the physical function by the variable “work and school” and treatment, role limitations due to physical health by the variable of work and school, the role limitations due to emotional problems by the variable of treatment, emotional well-being by the variable of interpersonal relationships, pain by the variable of symptoms and feelings, daily activities, and personal relationships were predictable. Finally, social function, general health and fatigue cannot be predicted by any variable.
Conclusion: The results of this study indicated that the quality of dermatology life is able to predict some aspects of quality of life. These findings can be used to provide better health services to this group of patients and improve their quality of life.
Corticosteroid Versus Dextrose Ultrasound-Guided Injection in the Treatment of Sacroiliac Joint Dysfunction: A Randomized Double-Blinded Clinical Trial
Authors: Raissi Gholamreza , Ahadi Tannaz , Forogh Bijan , Moradi Katayoun , Madani Seyed Pezhman , Yousefi Naseh , Foroumadi Roham , Rahimi-Dehgolan Shahram 
Published: December 2022

Background: Sacroiliac Joint (SIJ) dysfunction, a common etiology of Low Back Pain (LBP), is a challenging diagnosis. There is controversy over the efficacy of prolotherapy and corticosteroid injections in relieving SIJ dysfunction. Inconsistent success rates reported in previous studies can be due to heterogeneity in selecting the patients and procedures between studies. This study was conducted to compare the efficacy of local injection of dextrose prolotherapy and corticosteroid in treating the SIJ dysfunction.
Methods: This 36-week, double-blind, Randomized Controlled Trial (RCT) included 40 patients with SIJ dysfunction. The clinical impression was confirmed by the use of a diagnostic injection of local anesthetic inside SIJ. Participants received a single injection of either hypertonic dextrose solution or triamcinolone under Ultrasound (US) guidance. The primary outcome measurement tools, including the Visual Analog Scale (VAS) for pain and the Dallas Pain Questionnaire (DPQ), were evaluated initially and after 2, 8, and 36 weeks.
Results: In both prolotherapy and corticosteroid groups, VAS significantly declined within 36-weeks of follow-up. However, there was no remarkable difference between the two groups at any follow-up timepoints. Similarly, DPQ revealed a remarkable improvement in the corticosteroid group while it did not show any meaningful change in the prolotherapy group.
Conclusion: Both local injections of dextrose and corticosteroids can successfully reduce pain in patients with SIJ dysfunction without significant superiority between the two treatments. However, corticosteroid injection was slightly more effective in terms of improvement of functional status. Further investigations are required to extend these results to SIJ dysfunction treatment more reliably.
O uso de antidepressivos na gestação
Authors: Dotto Bethina Segabinazzi , Dal Bó Silvia 
Published: December 2022

A depressão está diretamente relacionada com quadros de alterações psicopatológicas diversas, porém diferenciam-se consideravelmente em relação à sintomatologia, gravidade, curso e prognóstico. O aparecimento e a presença de transtornos psiquiátricos no período reprodutivo são comuns em mulheres e seu tratamento no ciclo gestacional é complexo, necessitando tomada de decisões clínicas difíceis. Sabe-se também que o período perinatal é desencadeador ou reativador de quadros depressivos assim como a depressão pós-parto que se inicia durante a gestação e não é reconhecida. O acompanhamento do obstetra durante o pré-natal é essencial para o reconhecimento de sintomas que permitam intervenções precoces e para prevenção dos quadros mais graves. Apesar da morbidade associada às doenças psiquiátricas, existe uma prevalência em se evitar o uso de psicofármacos durante a gestação. Diante disso, este trabalho objetivou por meio de revisão de artigos e a análise dos dados, procurar evidenciar os riscos e benefícios do uso de antidepressivos no período gestacional, bem como de alguma forma, procurar identificar os mais indicados para uso nesse período. Palavras chaves: depressão, antidepressivo, gravidez.
Evaluation of intravarietal polymorphism of tomato fungal disease resistance genes in Michurinsky State Agrarian University breeding varieties
Authors: Shamshin I. N. , Ilyichev A. S. , Grosheva E. V. 
Published: December 2022

Relevance. The studies are aimed at assessing the intravarietal allelic diversity of genes for resistance to fusariosis and cladosporiosis of tomato cultivars bred at the Michurinsky State Agrarian University using molecular markers.Methods. The biological objects of the study are tomato varieties bred at the Michurinsky State Agrarian University. A total of 10 varieties were analyzed. The assessment of intravarietal polymorphism was determined on a sample of 10 plants of each variety. DNA extraction was performed using a Quick-DNA Plant/Seed Miniprep Kit (Zymo Research, USA) for DNA extraction according to the manufacturer's protocol. The P7 DNA marker was used to identify the cladosporosis resistance gene Cf-19. The presence of the fusarium wilt resistance gene I-2 was determined using the marker I-2/5. Amplification results were visualized by electrophoresis in 2% agarose gel.Results. 10 plants of 10 varieties of Michurinsky GAU selection tomato were analyzed using molecular markers of genes for resistance to cladosporiosis and fusariosis. An assessment of intravarietal polymorphism was carried out. In most of the varieties studied, the genes analyzed are identified in a heterozygous state. Three varieties (Vivat, Carotinka, Krasavets) containing only alleles of susceptibility to the causative agent of the disease in the genotype I-2 identified by the gene. Individual samples were homozygous for the fusariosis resistance allele. Analysis of the gene for Cf-19 resistance to cladosporiosis showed that most of the varieties studied are heterozygous forms. In some varieties, all ten plants were heterozygous. These include Krasavets, Vivat, Orlik, Bui Tour. The remaining samples had different allelic compositions. The pathogen resistance allele has been identified in plants of the Nepryadva and Chernysh varieties. The dominant allele in the homozygous state was detected in the Japanese variety. At the same time, all the analyzed plants of this variety were monotonous.Conclusion. It has been established, but a significant part of the varieties of tomato selection of Michurinsky GAU is polymorphic in the genes for resistance to cladosporiosis and fusariosis. In this case, a significant part of the varieties can be used in selection during preliminary molecular analysis. According to the gene for resistance to fusariosis, the following varieties are identified sources of the resistance allele: Sokol, Nepryadva, Yaponchik, Orlik, Zolotnichok, Chernysh. In them, the gene is I-2 represented in a heterozygous state. Intraortic polymorphism was also noted for the Cf-19 gene. Most samples have two alleles. The exception is the Japanese variety, which is the dominant homozygote for this gene.
Efektivitas Gakkumdu dalam Peraturan Bawaslu Nomor 31 Tahun 2018 Ditinjau dari Teori Penegakan Hukum
Authors: Alhuda Bukhari 
Published: December 2022

Bawaslu sebagai pengawas jalannya pemilihan umum membentuk Sentra Gakkumdu (Penegakan Hukum Terpadu) untuk mengawal penegakan tindak pidana dalam pelaksanaan pemilihan umum agar tercapai pemilihan umum yang tertib dan adil serta dalam terbentuknya Gakkumdu (Penegakan Hukum Terpadu) dalam menangani tindak pidana Pemilu. Keanggotaan Gakkumdu (Penegakan Hukum Terpadu) sendiri terbentuk dari tiga lembaga yakni Bawaslu, Kepolisian, Kejaksaan. Tujuan penelitian ini adalah untuk menganalisis efektivitas Gakkumdu dalam Peraturan Bawaslu Nomor 31 Tahun 2018 Tentang Sentra Gakkumdu.Penelitian yang digunakan adalah jenis penelitian normatif yang prosesnya menganalisis peraturan yang ada dengan permasalahan yang terjadi. Pendekatan penelitian menggunakan pendekatan perundang-undangan dan konseptual yang berusaha mendeksripsikan dan menganalisa hasil penelitian yang didapatkan dari perundangg-undangan. Hasil penelitian ialah hukum Lawrence M. Friedman keberhasilan dan efektivitas penegakan hukum bergantung pada tiga unsur, yaitu struktur hukum (legal structure) dalam hal ini yaitu Sentra Gakkumdu ( Bawaslu, Kejaksaan, Kepolisian) yang belum bisa menuntaskan masalah pelanggaran Pemilihan Umum yang jujur, adil dan transparan sesuai asas Pemilihan Umum dan wewenang yang dimiliki antara ke tiganya masih sering terjadi beda pemahaman. Substansi hukum (legal subtance) Nomor 7 Tahun 2017 Tentang Pemilihan Umum dan Peraturan Bawaslu Nomor 31 Tahun 2018 Tentang Sentra Gakkumdu belum bisa memberikan aturan yang tegas mengenai bagaimana mengatur bahwa pelanggaran tindak pidana bisa dikategorikan pidana atau tidaknya karena masih banyaknya perkara yang lolos di ranah persidangan oleh Hakim sehingga perlu adanya revisi terkait peraturan tersebut baik itu dengan membuat peradilan khusus atau perombakan Sentra Gakkumdu sesuai tugasnya dengan jelas dan tersistem. Terakhir adalah budaya hukum (legal culture), berkaitan dengan tidak efektivnya adanya Gakkumdu (Penegakan Hukum Terpadu) karena masih banyak masyarakat yang melakukaan pelanggaran Pemilihan Umum mulai dari kampanye, politik uang atau alat peraga kampanye.
Kata Kunci: Efektivitas, Sentra Gakkumdu, Penegakan Hukum
De la visión a la acción
Authors: Peiró López Juan Bautista , Rodríguez Arias Angel Manuel 
Published: December 2022

Este artículo de investigación se configura a través de dos partes. En la primera, de carácter historiográfico y contextual, se genera un recorrido de la noción de naturaleza en el arte a través de la obra de diferentes autores. Este estudio se inicia con la concepción del paisaje como género pictórico, hasta las propuestas contemporáneas de acción e intervención en el medio natural. Posteriormente, en la segunda parte de esta investigación es empleada la metodología de caso de estudio para analizar la obra de tres artistas contemporáneas: Ana Donat, Anaïs Florin y Virginia Bersabé. Abarcamos su trabajo para entender como se configuran actualmente propuestas artísticas de intervención en el espacio de la periferia, vinculadas a una concepción del territorio desde una mirada crítica y transformadora.
CADRE EMPOWERMENT PROGRAM FOR HYPERTENSION PREVENTION IN VILLAGE JUBEL, BANTUR VILLAGE, BANTUR DISTRICT
Authors: Purwanza Sena , Wahyudi Yuyud 
Published: December 2022

Introduction: hypertension is the highest degenerative disease in Malang Regency and the second rank in East Java Province. One effort that is sufficient is to apply the Health Belief Model to predict and explain variations in healthy living behavior. This study aims to determine the effectiveness of the cadre empowerment intervention program in preventing hypertension. Methods: This research was conducted in January - February 2022 using a quasi-experimental research design using a two-group pretest-posttest design with a control group design with a sample of 12 cadres with a total sampling technique. Results: The results of this study indicate that the cadre empowerment program before the intervention (pre-test) was mostly adequate, after the intervention (post-test) most of the behavior was sufficient. Conclusion: the cadre empowerment program showed effective test results because there was an increase from before and after the intervention.
Keywords: cadre empowerment intervention; hypertension; prevention
INVESTIGATION OF THE CLINICOPATHOLOGICAL IMPORTANCE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO IN BREAST CANCER
Authors: KARAYİĞİT Ahmet , ÖZDEMİR Dursun Burak , DİZEN Hayrettin , ULAŞ Murat , ÜNAL Bülent 
Published: December 2022

AIM: In this study, we aimed to examine whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values of women operated for breast cancer were associated with their clinicopathological features.
MATERIAL AND METHOD: The data of 463 females who were operated for breast cancer in our center between Januray 2015 and December 2020 were analyzed retrospectively. Age, menopausal status, hematological values, histopathological features of tumors, presence of hormone receptors, surgical and biopsy techniques were evaluated in detail. NLR and PLR values were calculated using the results of routinely performed hemogram test before the operation, and their relationships with all parameters were analyzed.
RESULTS: The ages of the cases ranged from 23 to 88 years, with a mean of 53.57 ± 12.66. Postmenopausal women constituted 62.42% of the cases. A negative correlation was found between age and PLR, but neither PLR nor NLR were found to be associated with menopause status. It was found that high NLR value was associated with high N stage, high TNM stage, high number of metastatic lymph nodes and presence of extracapsular invasion (p
INTERCULTURAL COMMUNICATIVE COMPETENCE DEVELOPMENT IN JOURNALISM STUDENTS
Authors: Mykytenko Natalia , Fedorchuk Marta , Ivasyuta Olena , Hrynya Nataly , Kotlovskyi Andriy 
Published: December 2022

The paper is focused on the intercultural communicative competence as an integral part of vocational training of journalism students. The aim of the paper is: 1) to define the intercultural communicative competence dimensions; 2) to outline the ways of development of intercultural communicative competence of journalism students; 3) to find out the attitudes of journalism students to intercultural communicative competence development; 4) to assess the levels of journalism students’ intercultural communicative competence and develop recommendations for its development. A mixed research design was employed which involved 14 ESP teachers and 26 bachelor students of Ivan Franko National University of Lviv during the autumn trimester of 2021. The study shows that the students are fully aware of the necessity to develop intercultural communicative competence. Based on the survey of the ESP teachers, we outlined the dimensions of journalism students’ intercultural communicative competence development and suggested the ways of building intercultural communicative competence in journalism students. The levels of assessment of intercultural communicative competence of journalism students were outlined and defined. The final results indicate that journalism students whose study was more practice than theory oriented (group 1) showed better learning outcomes than those who were mostly focused on the acquisition of theoretical knowledge (group 2). Methodical guidelines for ESP teachers were developed.
El "Narkomfin" y los apartamentos "La Nao". Aportaciones de la sección 3-2
Authors: Peris Blat Ignacio , Sanchis Gisbert Salvador José , Ponce Gregorio Pedro 
Published: December 2022

ResumenEntre los frutos de las investigaciones llevadas a cabo por el Departamento de Estandarización del Stroikom en la antigua URSS, encontramos el llamado tipo F que se convertirá en un referente para la arquitectura residencial de la modernidad. Su característica sección 3-2, materializada en el edificio "Narkomfin" (Moscú, 1928-1930), supone una importante aportación a las posibilidades espaciales de la vivienda colectiva y ha sido un modelo para un gran número de realizaciones posteriores. Entre todas ellas, nos resulta especialmente interesante, para su confrontación con la obra de Moscú, el caso de los apartamentos "La Nao" (Jávea, 1962-1966) de Santiago Artal, por tratarse de una obra muy poco conocida y estudiada. Este edificio es la continuación de la labor iniciada por el arquitecto valenciano en su primer trabajo de "Santa María Micaela". A partir del análisis y del redibujado de las viviendas, y pese a tratarse de dos actuaciones de escalas y contextos urbanos muy diferentes, trataremos de hacer un estudio comparado que nos permita poner en valor esta obra de Artal dentro del contexto arquitectónico de los primeros años 60. Abstract Among the results of the research carried out by the Standardization Department at Stroikom in the former USSR, we find the so-called F-type, which became a reference for modern residential architecture. Its distinctive 3-2 section, materialized in the "Narkomfin" building (Moscow, 1928-1930), represents an important contribution to the spatial possibilities of collective housing and has been a model for a large number of subsequent projects. Among all of them, the case of the "La Nao" apartments (Jávea, 1962-1966) by Santiago Artal is particularly interesting for its comparison with the Moscow building, as it is a little-known and little-studied work. This building is the continuation of the endeavor the Valencian architect began with his first work on "Santa María Micaela". Based on the analysis and the redrawing of the dwellings, and despite being two works with very different scales and urban contexts, we will try to carry out a comparative study that will allow us to highlight Artal's work within the architectural context of the early 1960s.