bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent progress on the non-point source pollution research from the World and China’s perspective: A bibliometric analysis from 2012 to 2021
Authors: Xie Zijian , Ye Chun , Li Chunhua , Shi Xiaogang 
Published: March 2022

Abstract
Background
With the effective control of point source pollution, the non-point source (NPS) pollution has been widely concerned as the primary reason for the improvement of global water environmental quality. At present, China is one of the countries with the highest research attention on NPS pollution. The Chinese government pays great attention to the environmental problems caused by the NPS pollution. Therefore, it is of great significance to clarify the global trends of NPS pollution and illustrate the importance of China on the NPS pollution research around the world.
Results
A bibliometric analysis was conducted based on 3407 publications retrieved from the Web of Science during 2012–2021. China, the USA and UK were the most productive countries. Articles published from China accounting from 23–50% between 2012–2021. Regarding the top 20 most productive authors, 17 of them from China. The most productive 21 institutions were located in China (15) and the UK (6). The Chinese Academy of Sciences stood out, followed by the Beijing Normal University. The Sci. Total Environ ranked first in the most productive journals, followed by Environ. Sci. Pollut. Res and Water. China was the major contributor to these journals, accounting from 24–79%. The most highly cited articles were published in Proc. Natl. Acad. Sci. U.S.A. The keywords analysis showed that nitrogen and phosphorus were the common NPS pollutants. Agricultural NPS pollution and urban NPS pollution were the main NPS types. The land use change, rainfall and irrigation were the main driving factors of NPS pollution. Load calculation and Integrated management were the key points of NPS pollution technology research. The NPS pollution research objects were mainly distributed in the surface water and groundwater, while the ocean might be the hot areas in the future research.
Conclusions
This study demonstrates the global trend of NPS pollution research during 2012–2021 according to analyzing the annual publication outputs, source journals, source country, author, institution and the high-frequency keywords. Meanwhile, the importance of China on NPS pollution research is explained from the bibliometrics perspective. It is beneficial for guiding the future research of NPS pollution.
Ankle brachial index and cognitive function among elderly hypertensive patients with different age stratification: a 2-year longitudinal study
Authors: Chen Hui , Li Min , Liu Lei , Shi Anshi , Yin Zhe , Tian Gang 
Published: March 2022

Abstract
BackgroundThe ankle brachial index (ABI) is widely used to evaluated peripheral artery disease and atherosclerosis. This study was designed to evaluate the association between the ABI and cognitive function in elderly hypertensive patients stratified by age. MethodsA total of 408 elderly hypertensive patients from two hospitals were included, and followed up for two years. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). Multivariate logistic regression analysis was employed to evaluate the association between ABI and cognitive impairment, and the analysis of covariance (ANCOVA) was used to compare the cognitive decline according to the ABI during 2-year follow-up in different age groups adjusted for related confounding factors.ResultsThe ABI was independently associated with cognitive impairment in overall and old elderly (75 ~ 89 years old) hypertensive patients (all P < 0.05), but not in the young elderly (60 ~ 75 years old) (P = 0.113). During ANCOVA, the MMSE score decline value of the low ABI group was greater than that of the high ABI group (0.767 vs 0.244; F = 5.845, P = 0.016) over 2-year follow-up. There was a significant difference of MMSE score decline value between the young and old elderly (0.345 vs 1.005; F = 4.728, P = 0.031) in Low ABI group, but no significant difference was found in High ABI group (P = 0.235). ConclusionsThe ABI was associated with cognitive impairment and cognitive function decline in elderly hypertensive patients, especially in the old elderly. Early monitoring of the ABI and initiation of individualized anti-atherosclerotic therapy might help prevent cognitive impairment in elderly hypertensive patients more effectively.
Research Progress on Three-dimensional Greening of High-Density Urban Spaces
Authors: Wang Wei , Song Yuan , Li Jiaqi , Zhang Jinbang , Lv Wujie 
Published: March 2022

Abstract
Urbanization has resulted in increased population density and scarcity of space, leading to the loss of greenery in urban areas, while also increasing the density of buildings and urban spaces. As an important development direction of urban greening, three-dimensional greening plays an important role in the ecological economy and landscape development of the city, especially for the improvement of the ecological environment of high-density cities. Focusing on the research progress of high-density urban space greening, this paper summarizes the application mode, technical points and plant configuration of three-dimensional greening in high-density urban space, and provides a scientific basis and relevant prospects for the sustainable development of high-density urban three-dimensional greening.
Clinical outcomes and visual prognostic factors in congenital aniridia
Authors: Jacobson Adam , Mian Shahzad I. , Bohnsack Brenda L. 
Published: March 2022

Abstract
Background: Evaluate outcomes and identify prognostic factors in congenital aniridia. Methods: Retrospective interventional case series of patients with congenital aniridia treated between 2012-2020. Ocular examination and surgical details were collected. Surgical failure was defined as disease progression or need for additional surgery for same/related indication. Kaplan-Meier survival curves, Wilcoxon test, and univariate and multivariate linear regression analyses were performed. Results: Ninety-four patients with congenital aniridia presented at median 19.0 years. Two-thirds of patients underwent > 1intraocular surgery, with average of 1.7 ± 2.3 surgeries/eye. At final follow-up (median 4.0 years), 45% of eyes had undergone lensectomy. Aphakic eyes showed worse visual acuity (VA) than phakic or pseudophakic eyes. Glaucoma affected 52% of eyes, of which half required IOP-lowering surgery. Glaucoma drainage devices showed the highest success rate (71%) at 14.2±15.4 years of follow-up. Keratopathy affected 65% of eyes and one-third underwent corneal surgery. Keratoprosthesis had the longest survival rates at 10-years (64% with 95% CI [32,84]). LogMAR VA at presentation and final follow-up were not statistically different. Half of patients were legally blind at final follow-up. Final VA was associated with presenting VA, glaucoma diagnosis, and cataract or keratopathy at presentation. Penetrating keratoplasty and keratoprosthesis implantation correlated with worse BCVA. Conclusions: Most aniridic patients in this large US-based cohort underwent at least 1 intraocular surgery. Cataract, glaucoma, and keratopathy were associated with worse VA and are important prognostic factors to consider when managing congenital aniridia.
Tolerance to oral anticancer agent treatment in older adults with cancer: A secondary analysis of data from EHRs and a pilot study of patient-reported outcomes
Authors: Jiang Yun , Mason Madilyn , Cho Youmin , Chittiprolu Ankita , Zhang Xingyu , Harden Karen , Gong Yang , Harris Marcelline R. , Barton Debra L. 
Published: March 2022

Abstract
Background: More than 60% of cancer cases occur in older adults, and many are treated with oral anticancer agents (OAAs). Yet, OAA treatment tolerability in older adults has not been fully understood due to their underrepresentation in oncology clinical trials, creating challenges for treatment decision-making and symptom management. The objective of this study was to investigate the tolerance of capecitabine, an OAA, in older adults with cancer and explore factors associated with capecitabine-related side effects and treatment changes, to enhance supportive care.Methods: A secondary analysis used combined data from electronic health records and a pilot study of patient-reported outcomes, with a total of 97 adult patients taking capecitabine during 2016-2017, including older adult patients aged 65 years or older (n=43). The data extracted included patient socio-demographics, capecitabine information, side effects, and capecitabine treatment changes (dose reductions and dose interruptions). Bivariate correlations, negative binomial regression, and multiple linear regression were conducted for data analysis. Results: Older adults were more likely to experience fatigue (86% vs. 51%, p=.001) and experienced more severe fatigue (β=0.44, p=.03) and HFS (β=1.15, p=.004) than younger adults. The severity of fatigue and HFS were associated with the number of outpatient medications (β=0.06, p=.006) and the duration of treatment (β=0.50, p=0.009), respectively. Correlations among side effects presented differently between younger and older adults. Older adults also tended to be more likely to experience dose reductions (21% vs. 13%) and dose interruptions (33% vs. 28%) than younger adults. Females, breast cancer diagnosis, capecitabine monotherapy, and severe HFS were found to be associated with dose reductions (ps<0.05). Conclusions: Older adults were less likely to tolerate OAA treatment and had different co-occurring side effects compared to younger adults. While dose reductions are common among older adults, age 65 years or older may not be an independent factor of treatment changes. Other socio-demographic and clinical factors may be more likely to be associated. Future studies can be conducted to further explore older adults’ tolerance to a variety of OAAs to generate more evidence to support optimal OAA treatment decision-making and symptom management among older adults.
X-mode laser coupling to upper hybrid wave in a plasma embedded with clusters
Authors: Babu Sanjay , Jeet Ram , Kumar Arvind , Kumar Asheel , Varma Ashish 
Published: March 2022

Abstract
A large amplitude X-mode laser, propagating perpendicular to the static magnetic field B s || z ˆ , through a clustered plasma parametrically couples to upper hybrid wave and a lower hybrid wave. Coupling occurs due to ponderomotive force by the high frequency upper hybrid waves and low frequency density perturbation beating with the oscillatory velocity due to X-mode laser. The cluster Plasmon resonance strongly modifies the nonlinear coupling between upper hybrid and lower hybrid waves. Fluid theory is employed to obtain the response of plasma electrons and cluster electrons to upper hybrid and lower hybrid mode. For typical parameters, eA 0 / m ω cc = 0.2,0.3, k 0 x = 2ω c / c , k 1⊥ ≈ 0.8ω0 / c , ω0 = 2ω c , ω2 pe /ω2 p =10, ω c / ω p =1, k 1 z / k 1 =.16 , (4π/3) r c 3 n c = 0.001, the growth rate is maximum when ω 1 /ω UH = 0.35 .
Prediction of cooking characteristics of moisture conditioned and infrared heated cowpea using Artificial neural network
Authors: Ogundele Opeolu .M. , Akintola Ayooluwa. T. , Fasogbon Beatrice M. , Adebo Oluwafemi. A. 
Published: March 2022

Abstract
Cowpea is widely grown and consumed in Sub-Saharan Africa because of its low cost and high mineral, protein, and other nutritional content. Nonetheless, cooking it takes considerable time, and there have been attempts on techniques for speeding up the cooking process without compromising its nutritious value. Infrared heating has recently been proposed as a viable way of preparing instantized cowpea grains that take a short amount of time to cook while maintaining desired sensory characteristics. Despite this, only a few studies have shown the impact of moisture, temperature, and cooking time on cooking characteristics such as bulk density, water absorption (WABS), and the pectin solubility of infrared heated cowpea precooked using this technology. Artificial neural network was used as a machine learning tool to study the effect of a prediction model on the infrared heating performance and cooking characteristics of precooked cowpea seeds. With R values of 0.987, 0.991, and 0.938 for the bulk density, WABS, and pectin solubility, respectively, the prediction model created in this study utilizing an artificial neural network (a type of machine learning) outperformed the traditional linear, 2-Factor Interaction (2FI), and quadratic models.
Revascularization Procedures for Moyamoya Disease without Mayfield Skull Clamp
Authors: Fatima Nida , Dine Anna K. La , Barnard Zachary R , Lekovic Gregory P 
Published: March 2022

Abstract
Moyamoya disease (MMD) is a pathophysiologically complex disorder characterized by progressive stenosis of the internal carotid arteries at the skull base and formation of circuitous and expanded collaterals angiographically “puff of smoke” at the base of brain. However, these collateral blood vessels are fragile and prone to ischemic or hemorrhagic events during the peri and intra-operative period. Direct and indirect bypass techniques have been devised with the goal of promoting angiogenesis, inducing formation of collateral vessels, and restoring perfusion to the oxygen deprived area of the brain. Mayfield skull clamp can cause blood pressure instability. This technical note highlights the surgical management of MMD without the use of Mayfield skull clamp with the goal of minimizing risk of perioperative blood pressure volatility.
Bismuth fire assay preconcentration and modified empirical coefficient method LA-ICP-MS for the simultaneous determination of ultra-trace Pt and Pd in geochemical samples
Authors: Ni Wenshan , Mao Xiangju , Yao Mingxing , Guo Xiaorui , Sun Qiliang , Gao Xiaofei , Zhang Hongli 
Published: March 2022

Abstract
In this work, a novel green method of solid sample pretreatment technique of bismuth fire assay (Bi-FA) combined with solid sample determination by laser ablation ICP-MS (LA-ICP-MS) was reported for the determination of ultra-trace Pt and Pd in geochemical samples. Bismuth oxide (Bi2O3) was used as fire assay collector to directly enrich Pt and Pd from solid samples, and Ag protection cupellation was employed to generate Ag granules. After cleaning, weighing and annealing, the Ag granules were compressed into thin slices and determined by LA-ICP-MS for 195Pt, 105Pd and 109Ag (109Ag was selected as the internal standard isotope). Bi2O3 provided exceptionally low blanks compared to nickel oxide and lead oxide commonly employed in fire assay procedures, and could be applied directly without purification. Different from traditional empirical coefficient method, the Chinese Certified Reference Materials (CRMs) for Pt and Pd were treated by the same procedure to obtain completely matrix matched Ag slices. And then modified empirical coefficient method and internal standard calibration strategy was used to reduce the instability of LA-ICP-MS, and random multipoint laser ablation was employed to further reduce analytical variation resulting from heterogeneity of Pt and Pd in the Ag slice. Under optimal conditions, excellent calibration curves for Pt and Pd were obtained (0.4071 ~ 2958 μg g-1 and 0.4071 ~ 2636 μg g-1, respectively), with correlation coefficients exceeding 0.9996. The method detection limits for Pt and Pd were 0.074 and 0.037 ng g-1, respectively. The established method was applied successfully to analysis of real geochemical samples, with determined values in good agreement with the results of traditional Pb-FA graphite furnace atomic absorption spectrometry (GF-AAS), and spiked recoveries between 87.8% and 125.0%.
Metagenomic Analysis of the Microbiome of the Upper Reproductive Tract Focuses on Prediction, Prevention, and Personalized Medicine to Combat Ovarian Cancer
Authors: Qin Xu , Zhou Jianglin , Wang Zizhuo , Feng Chenzhao , Fan Junpeng , Huang Jia , Hu Dianxing , Baban Babak , Wang Shengqi , Ma Ding , Sun Chaoyang , Zhou Zhe , Chen Gang 
Published: March 2022

Abstract
Purpose
To explore whether there are particular genital microbiota compositions in the reproductive tract in ovarian cancer patients and analyze their potential impact on the preventive, precisive, and personalized treatment.
Methods
The samples of cotton swabs from the cervical, uterine cavity, fallopian tubes, and ovaries were collected in the operation of the malignant/benign lesion patients, and subjected to metagenomic shotgun sequencing analysis. The distribution characteristics of the microbiota in the reproductive tract of different patients was analyzed with the consideration of associated clinical data.
Results
Bacteria accounted for the highest proportion in each sample, with a median of 99%. The microbiota of the upper female reproductive tract are mainly from the cervical, charactering in low bacterial biomass and high bacterial diversity. Ovarian cancer had a distinct microbiota signature. The tubal ligation affects its microbial distribution. There were no different species on the surface of ovarian tissue between platinum-sensitive and platinum-resistant patients.
Conclusion
The identification of the distinct microbiota may benefit in the prediction as well as prevention of different types of ovarian cancer. Moreover, it may dedicate to strengthen the therapeutic effect of adjuvant treatment of cancer. These findings may provide new strategies for prevention, diagnosis, and therapeutic effects to enhance health outcomes for women with ovary cancer.
Safety Analysis of Immunochemotherapy Combined With Consolidative Thoracic Radiotherapy for Extensive-stage Small Cell Lung Cancer
Authors: Li Yuying , Jing Xuquan , Chang Jiayu , Li Jiatong , Zhang Yan , Guo Jun , Tang Xiaoyong , Zhu Hui 
Published: March 2022

Abstract
Background: It has been evaluated that thoracic radiation therapy (TRT) could improve the local control and give survival benefit for the patients with extensive-stage small cell lung cancer (ES-SCLC) in the era of chemotherapy. However, there was no data to indicate the safety especially the lung toxicity of TRT during the maintenance of programmed death ligand 1(PD-L1) inhibitors after four cycles of PD-L1 inhibitors with etoposide and platinum (EP). Hence, the retrospective study aimed to investigate the risk factors of radiation pneumonitis (RP) of TRT combined with PD-L1 inhibitors.Methods: From January 2020 through March 2021, in Shandong Cancer Hospital and Institute, patients with ES-SCLC who received TRT during the maintenance of PD-L1 inhibitors after administrating PD-L1 inhibitors with EP were enrolled in the retrospective study. RP was investigated and evaluated according to the Common Terminology Criteria for Adverse Events version 5.0(CTCAE v5.0) criteria. We used univariate and multivariate logistic regression to analyze the potential risk factors of RP.Results: During January 2020 to March 2021, 20 patients receiving TRT during the maintenance of PD-L1 inhibitors after administrating PD-L1 inhibitors with EP were enrolled in the retrospective study. The dose fractions were 1.5Gy bid or 1.8-3Gy qd and the total dose was 30Gy to 61.4Gy. As a result, 6 patients (30%) experienced grade 2 RP, and no ≥3 grade RP occurred. At the last time of follow-up, 17 patients suffered from disease progression, 13 of them suffered from distant progression and three suffered from local failure in radiation field and one suffered from distant progression and local failure in radiation field. The median progression-free time (PFS) was 9 months.Conclusion: The retrospective analysis showed that the lung toxicity of TRT was tolerable during the maintenance of PD-L1 inhibitors after administrating PD-L1 inhibitors with EP.
Evaluation on potential detriments from lockdown-related isolation to mental health among school-aged youth in central China
Authors: Li Yichen , Hou Zhanfeng , Sun Ken , Ma Jun , Zhou Chenmiao , Zhang Wen , Chen Feng , Chen Mo-Xian , Wong Nai-Kei , Zhang Xiao-Fan 
Published: March 2022

Abstract
Background: Home isolation is a generally effective strategy for coronavirus disease control during lockdown periods. This study is to determine the potential adverse consequences of home isolation to mental health among school-aged youth after lifting of major lockdown measures in central China. Methods: This cohort study assessed the mental health of school-aged children and adolescents enrolled in Wuhan city and nearby areas in Hubei province, China, from July 1 to August 31, 2020. Post-lockdown responses to anxiety, depression, sleep disturbances and post-traumatic stress symptoms were assessed in online questionnaire-based surveys. Participants’ scores for the Zung self-rated anxiety scale, the Patient Health Questionnaire-9, the self-rating scale of sleep and the post-traumatic stress disorder self-rating scale (PTSS) were analyzed. Results: Questionnaire responses of 730 school children were collected. Among the participants, 6.25% of them had scores above thresholds for PTSS, 5.81% had anxiety, and 48.84% had depression. All subjects reported that they experienced sleep disturbances. Subjects who had anxiety might have a high risk for developing depression [OR: 16.07, p =0.008, 95%CI (2.08-123.94)] and PTSS [OR: 12.97, p <0.001, 95%CI (5.41-31.11)]. Both depression [OR: 17.35, p =0.006, 95%CI (2.28-131.87)] and PTSS [OR: 14.18, p <0.001, 95%CI (6.00-33.47)] were risk factors for developing anxiety among participants. Interestingly, higher educational levels of primary caregivers were a risk factor for developing depression [OR: 1.62, p =0.005, 95%CI (1.16-2.28)] in the participants, but a protective factor against PTSS [OR: 0.47, p =0.048, 95%CI (0.23-0.99)].Conclusions: The local youth had less than expected degree of increases in their self-reported PTSS and anxiety, after exiting lockdown-related isolation. As a result of a combination of compensatory mechanisms including internet-based home-schooling and increased intra-familial interactions, home isolation did not affect the mental health of local school-aged youth to an extent as great as expected.Trial registration: The Registration number of this trial is ChiCTR2000033054.
Study of the thermomechanical behaviour of a concrete element
Authors: Douhi Réda Bouabdellah , Boualla Nabila , Khelafi Hamid , Yahiaoui Tayeb 
Published: March 2022

Abstract
The need to improve the safety of nuclear reactor containment has revealed the need for data on the thermomechanical behaviour of concrete in the event of an accident during which concrete is exposed to high temperatures. This work aims to study the influence of high temperatures on the behaviour of ordinary concrete specimens charged by a compression force. A thermal model is developed by a volumetric discretization (CASTEM). The results of various simulations, combined with other findings, allow a physical explanation of the thermomechanical phenomenon of concrete structures, which made it possible to obtain the variation of the stresses in any point or node and for each temperature in different directions X, Y and Z.