bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis: results from the international Pharmachild registry
Authors: van Straalen Joeri W. , de Roock Sytze , Giancane Gabriella , Alexeeva Ekaterina , Koskova Elena , Mesa-del-Castillo Bermejo Pablo , Zulian Francesco , Civino Adele , Montin Davide , Wulffraat Nico M. , Ruperto Nicolino , Swart Joost F. ,   for the Paediatric Rheumatology International Trials Organisation (PRINTO)
Published: November 2022

Abstract
Background
Little is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in parents of children with juvenile idiopathic arthritis (JIA).

Methods
Prevalence rates of ADs and 95% Poisson confidence intervals were calculated for parents of JIA patients from the international Pharmachild registry and compared with general population prevalence rates as reported in the literature. Demographic, clinical and laboratory features were compared between JIA patients with and without a family history of AD using χ2 and Mann-Whitney U tests.

Results
Eight thousand six hundred seventy three patients were included and the most common familial ADs were psoriasis, autoimmune thyroid disease, rheumatoid arthritis and ankylosing spondylitis. The prevalence of several ADs was higher in parents of the included JIA patients than in the general population. Clinical Juvenile Arthritis Disease Activity Scores at study entry and last follow-up were not significantly different between patients with (n = 1231) and without a family history of AD (n = 7442). Factors associated with familial AD were older age at JIA onset (P < 0.01), Scandinavian residence (P < 0.01), enthesitis-related arthritis, psoriatic arthritis and undifferentiated arthritis (P < 0.01), ANA positivity (P = 0.03) and HLA-B27 positivity (P < 0.01).

Conclusions
Familial AD proves to be a risk factor for JIA development and certain diseases should therefore not be overlooked during family health history at the diagnosis stage. A family history of AD is associated with the JIA category but does not influence the severity or disease course.
An ethnobotanical study on wild plants used by Tibetan people in Gyirong Valley, Tibet, China
Authors: Guo Chang-An , Ding Xiaoyong , Hu Huabin , Zhang Yu , Yang Huizhao , Wang Yuhua 
Published: November 2022

Abstract
Background
Gyirong Valley known as the “Back Garden of the Himalayas” is located in the core area of the Everest National Nature Reserve. It is also one of the important ports from ancient Tibet to Kathmandu, Nepal, since ancient times. Over the years, the Tibetans of Gyirong had accumulated sufficient traditional knowledge about local plant resources. However, there is almost no comprehensive report available on ethnobotanical knowledge about the local people. The purposes of this study were to (1) conduct a comprehensive study of wild plants used by Tibetan people in Gyirong Valley and record the traditional knowledge associated with wild useful plants, (2) explore the influence of Tibetan traditional culture and economic development on the use of wild plants by local people, and (3) explore the characteristics of traditional knowledge about wild plants of Tibetans in Gyirong.

Methods
Ethnobotanical data were documented through free listings, key informant interviews and semi-structured interviews during fieldwork. The culture importance index and the informant consensus factor index were used as quantitative indices.

Results
In total, 120 informants (61 women and 59 men) and 3333 use reports and 111 wild plant species belonging to 39 families and 81 genera were included. These use reports were then classified into 27 categories belonging to three major categories. The use category that contained the most plant species was edible plants (62), followed by medicinal plants (32) and economic plants (22), and other uses (71). Plants with high CI included Allium prattii, Neopicrorhiza scrophulariiflora, Gymnadenia orchidis, Rhododendron anthopogon and Fritillaria cirrhosa. Thirty-six species of plants in the catalog of Gyirong and Yadong were the same, but only 17 species were the same in Gyirong and Burang. There were only 11 overlapping species between all the three regions.

Conclusion
Tibetans of Gyirong have rich and unique knowledge about plant use, and wild edible and medicinal plants play an important role in the nutrition and health protection of local people. However, traditional knowledge is slowly being lost and is being hit by modern tourism. In the future, more attention needs to be paid to the important role of traditional knowledge in biodiversity conservation.
Parallel evolution of amphioxus and vertebrate small-scale gene duplications
Authors: Brasó-Vives Marina , Marlétaz Ferdinand , Echchiki Amina , Mantica Federica , Acemel Rafael D. , Gómez-Skarmeta José L. , Hartasánchez Diego A. , Le Targa Lorlane , Pontarotti Pierre , Tena Juan J. , Maeso Ignacio , Escriva Hector , Irimia Manuel , Robinson-Rechavi Marc 
Published: November 2022

Abstract
Background
Amphioxus are non-vertebrate chordates characterized by a slow morphological and molecular evolution. They share the basic chordate body-plan and genome organization with vertebrates but lack their 2R whole-genome duplications and their developmental complexity. For these reasons, amphioxus are frequently used as an outgroup to study vertebrate genome evolution and Evo-Devo. Aside from whole-genome duplications, genes continuously duplicate on a smaller scale. Small-scale duplicated genes can be found in both amphioxus and vertebrate genomes, while only the vertebrate genomes have duplicated genes product of their 2R whole-genome duplications. Here, we explore the history of small-scale gene duplications in the amphioxus lineage and compare it to small- and large-scale gene duplication history in vertebrates.

Results
We present a study of the European amphioxus (Branchiostoma lanceolatum) gene duplications thanks to a new, high-quality genome reference. We find that, despite its overall slow molecular evolution, the amphioxus lineage has had a history of small-scale duplications similar to the one observed in vertebrates. We find parallel gene duplication profiles between amphioxus and vertebrates and conserved functional constraints in gene duplication. Moreover, amphioxus gene duplicates show levels of expression and patterns of functional specialization similar to the ones observed in vertebrate duplicated genes. We also find strong conservation of gene synteny between two distant amphioxus species, B. lanceolatum and B. floridae, with two major chromosomal rearrangements.

Conclusions
In contrast to their slower molecular and morphological evolution, amphioxus’ small-scale gene duplication history resembles that of the vertebrate lineage both in quantitative and in functional terms.
“Issues emanating from business impact on climate, environmental sustainability and CSR (Corporate Social Responsibility): steps towards pragmatism in extant realities”: “Brand translation to equity from ‘CSR as a potential tool in climate change mitigation and enhancing financial performances in organizations”
Authors: Adewole Olukorede 
Published: November 2022

AbstractThe relationship between ‘CSR and Brands to the sustainable business environment coupled with climatic changes and environmental issues; ‘while emphasizing the potentials of ‘CSR from brand reputation translation to equity as a tool for mitigating climate change mitigation and enhancing corporate financial performances has been extensively presented.A value – based dimension becomes clear realizing the link and connection between ‘CSR, brand and brand association recognizing the key constructs and the translation of brand reputation to equity.The high R – value of 0.9753 between brand reputation and financial performances implies by adopting ‘CSR which enhances brand reputation and translates to equity; corporations, companies and organizations can use ‘CSR as a strategic tool for increased profitability and returns.It is extremely significant for companies, firms and corporations to take cognizance of ‘CSR and recognize its key roles as brand promoter, gaining increased customer and brand loyalty, and translation of brand reputation to brand equity.Finally, relevant models and novel proposed models have been presented extensively; ‘giving insightful delineation of this crucial subject emphasizing and stressing the need to also look beyond the models rather giving a complimentary treatment and consideration.‘CSR as a strategic tool built and imbibed in business model becomes crucial and can be the key driver and tool to abate climate change, gain increased brand loyalty and enhance financial performances.
Cognitive decline and alcohol consumption in the aging population—A longitudinal analysis of the Survey of Health, Ageing and Retirement in Europe
Authors: Listabarth Stephan , Groemer Magdalena , Waldhoer Thomas , Vyssoki Benjamin , Pruckner Nathalie , Vyssoki Sandra , Glahn Alexander , König-Castillo Deirdre Maria , König Daniel 
Published: November 2022

Abstract

Background
Prevalence of cognitive decline and dementia is rising globally, with more than 10 million new cases every year. These conditions cause a significant burden for individuals, their caregivers, and health care systems. As no causal treatment for dementia exists, prevention of cognitive decline is of utmost importance. Notably, alcohol is among the most significant modifiable risk factors for cognitive decline.

Methods
Longitudinal data across 15 years on 6,967 individuals of the Survey of Health, Ageing and Retirement in Europe were used to analyze the effect of alcohol consumption and further modifiable (i.e., smoking, depression, and educational obtainment) and non-modifiable risk factors (sex and age) on cognitive functioning (i.e., memory and verbal fluency). For this, a generalized estimating equation linear model was estimated for every cognitive test domain assessed.

Results
Consistent results were revealed in all three regression models: A nonlinear association between alcohol consumption and cognitive decline was found—moderate alcohol intake was associated with overall better global cognitive function than low or elevated alcohol consumption or complete abstinence. Furthermore, female sex and higher educational obtainment were associated with better cognitive function, whereas higher age and depression were associated with a decline in cognitive functioning. No significant association was found for smoking.

Conclusion
Our data indicate that alcohol use is a relevant risk factor for cognitive decline in older adults. Furthermore, evidence-based therapeutic concepts to reduce alcohol consumption exist and should be of primary interest in prevention measures considering the aging European population.
Estimating gravity acceleration from an atomic gravimeter by Kalman filtering
Authors: Jiang Bo-Nan , Wang Yu-Zhu 
Published: November 2022

Abstract
We present the construction of a two-state model of the atomic gravimeter and the associated Kalman recursion to estimate gravity acceleration from an atomic gravimeter. It is found that the Kalman estimator greatly improves the estimation precision in the short term by removing the white phase noise. The residual noise of the estimates follows

for more than

and highlights a precision of

at the measuring time of a single sample, even with no seismometer correction.
Screening the Port City: Poetics and Promotions
Authors: Moss-Wellington Wyatt , Rawnsley Ming-Yeh T. , Loo Yat Ming 
Published: November 2022

Abstract
This article contrasts a range of films from around the world that take place within port cities. It presents the port city film as a case of transnational “geographic imaginary” that dramatizes spaces of contact across lifeworlds. The authors find that there are two primary narrative modes in the port city film: a dominant mode in which gender, ethnic, class, and other identities bestowed by the geographic imaginary become inescapable, and a resistant or transformative mode in which characters are offered the opportunity to locate a new identity within a world of ephemeral relationships. Themes of criminality, poverty, and urban constituents struggling for personal agency, however, run counter to many city-branding narratives. The article concludes by comparing these fictional representations to a number of promotional and nonfictive examples of Chinese and British port city representations offering a very different vision of transnational contact—one that emphasizes a nation-building and growth “cleaned” of the human struggles for hybrid identity so vividly dramatized across port city fictions.
Murder, They Wrote: Genre and Collaboration in the Detection Club Novels
Authors: Briest Sarah 
Published: November 2022

Abstract
Members of a literary organization known as the Detection Club cowrote the mystery novels The Floating Admiral and Ask a Policeman in 1932 and 1933, respectively. These novels are of interest primarily for what they suggest about literary genre: the microcosms of their composition supply concrete, if playful, models of phenomena also at work in the macrocosm of genre fiction. Thus, collaborative writing emerges as a form of genre laboratory, ideally suited to the small-scale imitation and exploration of superordinate generic processes. Both the writers’ reflections on their collaborative efforts as well as the finished results of said efforts throw into stark relief the interdependent processes of writing and reading, semiotic encoding and interpreting, as they characterize the formation and reformation of generic conventions. Moreover, the ludic facets of the Detection Club collaborations indicate that the notion of (nonliterary) genre-as-game, as embraced by rhetorical genre studies, can be productively applied to literary genre.
Increase in Trigeminal Nerve Cross-Sectional Area on Immediate Postoperative MRI Predicts Favorable Outcome After Microvascular Decompression for Classical Trigeminal Neuralgia
Authors: Lee Changik , Choi Jin-gyu , Son Byung-chul 
Published: November 2022

BACKGROUND:
Although distortion or indentation of a trigeminal nerve due to neurovascular compression (NVC) is associated with classical trigeminal neuralgia, whether morphological change in the trigeminal nerve is relieved by eliminating NVC has not been studied.

OBJECTIVE:
To estimate morphological change in the trigeminal nerve after microvascular decompression (MVD).

METHODS:
Fifty patients with classical trigeminal neuralgia who underwent MVD were included. Using coronal images in both preoperative and postoperative MRI, the trigeminal nerve cross-sectional area (CSA) was measured at 4 mm anterior to the nerve entry into the pons. Clinical outcomes were assessed using the Barrow Neurological Institute Pain Intensity Scale (BNI-PS) at the patient's latest follow-up.

RESULTS:
Forty-one patients achieved favorable outcomes without medication (BNI-PS I or II), and 9 patients had residual pain (BNI-PS ≥ 3A). The mean symptomatic trigeminal nerve CSA was increased by 51.47% after MVD in the favorable outcome group (preoperative: 4.37 ± 1.64 mm2 vs postoperative: 6.26 ± 1.76 mm2, P < .01), whereas it was not significantly changed in the unfavorable outcome group (preoperative: 4.20 ± 1.19 mm2 vs postoperative: 4.43 ± 1.24 mm2, P = .69). Kaplan–Meier survival analysis showed that the 3-year probability of maintaining a favorable outcome was 92.3 ± 7.4% and 56.1 ± 11.9%, for those whose symptomatic trigeminal nerve CSA was increased by over 20% and less than 20%, respectively (P < .01).

CONCLUSION:
Morphological changes in the trigeminal nerve due to NVC could be recovered by MVD, and increases in the trigeminal nerve CSA predicted favorable outcomes.
Methods and Impact for Using Federated Learning to Collaborate on Clinical Research
Authors: Cheung Alexander T. M. , Nasir-Moin Mustafa , (Fred) Kwon Young Joon , Guan Jiahui , Liu Chris , Jiang Lavender , Raimondo Christian , Chotai Silky , Chambless Lola , Ahmad Hasan S. , Chauhan Daksh , Yoon Jang W. , Hollon Todd , Buch Vivek , Kondziolka Douglas , Chen Dinah , Al-Aswad Lama A. , Aphinyanaphongs Yindalon , Oermann Eric Karl 
Published: November 2022

BACKGROUND:
The development of accurate machine learning algorithms requires sufficient quantities of diverse data. This poses a challenge in health care because of the sensitive and siloed nature of biomedical information. Decentralized algorithms through federated learning (FL) avoid data aggregation by instead distributing algorithms to the data before centrally updating one global model.

OBJECTIVE:
To establish a multicenter collaboration and assess the feasibility of using FL to train machine learning models for intracranial hemorrhage (ICH) detection without sharing data between sites.

METHODS:
Five neurosurgery departments across the United States collaborated to establish a federated network and train a convolutional neural network to detect ICH on computed tomography scans. The global FL model was benchmarked against a standard, centrally trained model using a held-out data set and was compared against locally trained models using site data.

RESULTS:
A federated network of practicing neurosurgeon scientists was successfully initiated to train a model for predicting ICH. The FL model achieved an area under the ROC curve of 0.9487 (95% CI 0.9471-0.9503) when predicting all subtypes of ICH compared with a benchmark (non-FL) area under the ROC curve of 0.9753 (95% CI 0.9742-0.9764), although performance varied by subtype. The FL model consistently achieved top three performance when validated on any site's data, suggesting improved generalizability. A qualitative survey described the experience of participants in the federated network.

CONCLUSION:
This study demonstrates the feasibility of implementing a federated network for multi-institutional collaboration among clinicians and using FL to conduct machine learning research, thereby opening a new paradigm for neurosurgical collaboration.
Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy
Authors: Cao Chang , Fleming Mark D. 
Published: November 2022

ABSTRACT
Fetal development relies on adequate iron supply by the placenta. The placental syncytiotrophoblasts (SCTB) express high levels of iron transporters, including ferroportin1 (Fpn1). Whether they are essential in the placenta has not been tested directly, mainly due to the lack of gene manipulation tools in SCTB. Here, we aimed to generate a SCTB-specific Cre mouse and use it to determine the role of placental Fpn1. Using CRISPR/Cas9 technology, we created a syncytin b (Synb) Cre line (SynbCre) targeting the fetal-facing SCTB layer in mouse placental labyrinth. SynbCre deleted Fpn1 in late gestation mouse placentas reliably with high efficiency. Embryos without placental Fpn1 were pale and runted, and died before birth. Fpn1 null placentas had reduced transferrin receptor expression, increased oxidative stress and detoxification responses, and accumulated ferritin in the SCTB instead of the fetal endothelium. In summary, we demonstrate that SynbCre is an effective and specific tool to investigate placental gene function in vivo. The loss of Fpn1 in late gestation mouse placenta is embryonically lethal, providing direct evidence for an essential role of Fpn1 in placental iron transport.
ASSESSMENT OF THE PROFESSIONAL COMPETENCE OF A RURAL SCHOOL TEACHER
Authors: Zakharova Irina M. , Sadykova Lilia R. , Khakimova, Nailya G. 
Published: November 2022

The purpose of the work is to summarize the results of a pilot study of the assessment of the structural components of the professional competence of a rural school teacher, to determine the principles and directions of research on the design of a diagnostic map for assessing the professional deficits of a teacher working in a rural school.
Research methods. In the course of the research, a theoretical analysis of pedagogical literature was carried out, which allowed to clarify the degree of relevance and depth of study of the problem under study. The conducted pilot study of each teacher’s assessment of their level of pedagogical competence made it possible to determine the direction of designing practice-oriented tasks in order to diagnose professional deficits of a rural school teacher.
The results of the study. The theoretical analysis of the structural components of the professional competence of the teacher in the aspect of the implementation of the requirements of the updated Federal State Educational Standards and the developed draft Professional standard of the teacher. The results of a pilot study of the assessment of the structural components of the professional competence of a rural teacher, including a small school, are shown. The blocks of teachers’ competencies to be evaluated are defined: normative, subject, psychological and pedagogical, methodological and analytical. Various models for assessing the level of formation of professional competencies of teachers are presented and analyzed. The principles and directions of applied research on the design of a diagnostic card for assessing professional deficits of a teacher working in a rural school are determined.
The scope of the results. The article will be useful for teachers of pedagogical universities, organizations of additional professional education, students studying in the areas of “Pedagogical education”.
A STUDY OF THE CORRELATION BETWEEN SOCIONIC PERSONALITY TYPES AND TEMPERAMENT TYPES
Authors: Kovalenko Roman K. , Zvonareva Nataliya A. 
Published: November 2022

Purpose. The article is concerned with socionics, which is a typological approach-based framework that serves for modelling of the human capacity to perceive, process and produce information. The article studies the current state of socionics and the areas for further development. One of the primary focus areas of socionics is the experimental studies aiming to prove the construct validity of socionics. For this purpose, the correlation between socionic dichotomies and different psychologic models, such as a model of temperament, is studied. There are three hypotheses on a correlation between socionic personality types and temperament types.
Methodology. To conduct the research we used methods of socionic type identification, the Eysenck Personality Questionnaire adapted by Shmelev A.G., the “Type of Behavioral Activity” questionnaire by Wasserman L.I., and Gumenyuk N.V., and calculated the point-biserial correlation coefficient.
Results. The correlation analysis revealed a positive correlation between the Extraversion scale of the Eysenck Personality Questionnaire and the poles of Extraversion, Ethics and Declaring. A positive correlation is revealed between the Neuroticism scale of the Eysenck Personality Questionnaire and the Dynamic socionic pole, as well as between the Type of Behavioral Activity scale and the Extraversion pole. The findings confirm the hypothesis suggested by Gulenko W.W., according to which the socionic types correlate with the temperament types. They also confirm the hypotheses by Filatova E.S., and Stepanov R.A. / Lytov D.A., according to which Extraversion sensu Eysenck correlate to Extraversion, the socionic pole, and disprove their hypotheses on the correlation between the Neuroticism scale and socionic dichotomies.
Practical implications. The findings contribute to proving the construct validity of the socionics model. This ensures that practitioners who use socionic methods draw on the experimentally verified hypotheses.