bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Consumption of Marine Fish Nanoparticles on the Hardness of Teeth Enamel in Mice (Mus Musculus)
Authors: Putri Waritsa Arbyta , Christiono Sandy , Fathurrahman Helmi 
Published: January 2022

Struktur enamel terdiri dari 96 % bahan anorganik, 4% bahan organik, air dan jaringan fibrosa. Ikan laut memiliki banyak kandungan seperti Kalsium, Taurine, Omega 3, PUFAs, Vitamin A, Vitamin D, dan Fluorida yang memiliki fungsi dapat meningkatkan kekerasan enamel gigi. Penelitian ini bertujuan untuk mengetahui pengaruh konsumsi serbuk nanopartikel ikan laut terhadap kekerasan enamel gigi anak mencit (mus musculus).Metode penelitian ini menggunakan jenis penelitian True Experimental dengan rancangan penelitian menggunakan Post Test Only Control Design, terdiri dari 2 kelompok yaitu kelompok kontrol diberi pakan normal dan kelompok perlakuan diberi serbuk nanopartikel ikan laut dengan dosis 2,17 mg / 0,5 ml. Sampel yang digunakan adalah 16 ekor anak mencit kemudian masing-masing anak mencit diambil gigi insisivus. Selanjutnya gigi anak mencit dilakukan uji kekerasan Micro Vickers Hardness Tester, kemudian dianalisa dengan uji statistic. Hasil penelitian menunjukkan bahwa terdapat perbedaan signifikan antara kelompok perlakuan dan kelompok kontrol dengan signifikasi Independent T-test 0,000 (p0,05) pada rahang atas. Kesimpulan yang diperoleh adalah pemberian serbuk nanopartikel ikan laut dapat meningkatkan kekerasan enamel gigi secara signifikan dalam proses tumbuh kembang gigi janin mencit. Kata kunci : kekerasan enamel gigi; serbuk nanopartikel ikan laut; micro vickers hardness tester
Relationship between Dental Caries Risk Factors and Quality of Life in Elementary School Children
Authors: Haryani Wiworo , Siregar Irma HY , Yuniarti Etty 
Published: January 2022

The prevalence of dental caries among children in Indonesia is still high. Riskesdas data in 2018 shows that children aged 8-12 years are vulnerable to dental caries problems. Dental caries have an impact on children's quality of life. The purpose of this study was to determine the relationship between risk factors for dental caries and children's quality of life and the magnitude of the influence of each risk factor. This type of research is analytic observational with a cross-sectional design. The population is elementary school children in the area of Banyuraden, Gamping, Sleman, Yogyakarta. The time of the study was from March 2021 to August 2021. The sampling technique was carried out by purposive sampling; the number of samples was 200 children. The influence variable is the risk factor for dental caries, and the affected variable is the child's quality of life. The research instrument is a questionnaire consisting of 30 statement items. Assessment of dental caries risk factors includes knowledge of caries, tooth brushing behavior, and cariogenic food eating habits. In contrast, assessing children's quality of life is seen from oral cavity complaints, functional complaints, psychological complaints, and limitations of social interaction. Data were analyzed by univariate, bivariate, and chi-square tests. The results showed more children with low quality of life (67.0%) than children with high quality of life (33.0%). The chi-square correlation test results showed a significant relationship between knowledge about dental caries and children's quality of life (p=0.002; OR=2.77), between tooth brushing behavior and children's quality of life (p=0.012; OR=2.14). as well as between the habit of eating cariogenic foods with the quality of life of children (p=0.020; OR=2.03). This study concludes a significant relationship between knowledge, behavior, and eating habits with children's quality of life.
STUDY OF OUTCOME OF STATIN THERAPY IN PATIENTS BY CHECKING LIPID PROFILE AFTER 3 MONTHS OF STARTING TREATMENT IN STATIN NAIVE PATIENTS
Authors: Atwal Shilpa , Thakur Jitender 
Published: January 2022

Background: To describe the outcome of statin therapy in patients by checking lipid profile after 3 months of starting treatment in statin naive patients
Methods: Study was conducted on Patients with indications for statins presenting to cardiology OPD, Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months.
Results: The mean decrease in total cholesterol, triglycerides, VLDL and LDL levels in primary prevention group mean decrease in after 3 months of statin treatment in comparison to baseline were 17.24%,21.24%, 22.83 % and 33.19% respectively and increase in mean HDL level was 9.55%. The mean decrease in total cholesterol, triglyceride, VLDL and LDL levels in secondary prevention group after 3 months of statin treatment in comparison to baseline were 14.35% 15.80%, 16.17% and 36.92% respectively and increase in mean HDL level was 8.77%.
Concluded: So there was statistically significant change in lipid profile from baseline in both primary and secondary prevention groups after 3 months of statin treatment.
Keywords: Statin, LDL,VLDL, HDL
Efectividad de la consulta previa del proyecto Sociedad Portuaria Puerto Bahía, en el corregimiento de Pasacaballos de la Ciudad de Cartagena
Authors: Páez Payares Karen Margarita , Macías Seguanes Rosa Amelia , Matson Ospino William 
Published: January 2022

El objetivo propuesto en esta investigación consiste, en examinar la efectividad de la consulta previa realizada en el corregimiento de pasacaballos, de la ciudad de Cartagena con motivo del proyecto Sociedad Portuaria Puerto Bahía; para ello la metodología empleada fue la de la investigación socio jurídica y aplicada para el derecho y las técnicas de recolección de la información fueron las primarias ya que se aplicaron encuestas sociales a integrantes de la base social que viven en dicha localidad, para establecer su percepción sobre el grado de cumplimiento de los compromisos adquiridos por la Sociedad Portuaria Puerto Bahía en la Consulta Previa realizada por su Consejo Comunitario, y medir estadisticamente su impacto en el desarrollo socioeconómico de dicha comunidad; además se utilizaron fuentes secundarias como la ficha bibliográfica que permitió realizar un análisis de contenido a libros, capítulos de libros y artículos científicos y elaborar así el estado de la discusión sobre la consulta previa en Colombia a nivel normativo, jurisprudencial y doctrinal. Encontramos que los resultados de las encuestas sociales aquí analizadas estadísticamente denotan según el sentir de los encuestados, el poco desarrollo social del corregimiento mencionado entre los años 2014 a 2018, aun cuando el proyecto en mención, durante el desarrollo de la consulta previa realizada por el consejo comunitario pactó unas compensaciones proporcionales al daño recibido por los afrodescendientes que allí habitan, dada la imposibilidad de gozar y usar su territorio, por poner en riesgo su vida debido a la instalaciones portuarias que tiene una terminal de líquidos al granel, que además durará instalado por tiempo indeterminado.
Shellac dan Gelatin untuk Konsolidasi Artefak Kayu
Authors: Haldoko Leliek Agung 
Published: January 2022

Wood is a hygroscopic organic material, prone to damage and weathering, especially by humidity. The moisture in the wood will trigger biotic activities such as fungus, which can decompose of wood materials, that is, cellulose. Moreover, wood is susceptible to insect attacks such as termites. This condition will cause the wood to become brittle so that the strength of the wood will decrease. To strengthen brittle wood, consolidation treatments are needed. Material for wood consolidation that has been used is Paraloid B72 with acetone solvent, which is not easy to find everywhere
Materials tested for wood artifacts consolidations were shellac and gelatin with a concentration of 5%, 7,5%, and 10%. As a comparison, the material used for wood consolidation is Paraloid B72 10%. Test parameters used include SEM test, density test, compressive strength test, color change test, fungal growth observation, and FTIR test.
Test results have shown that shellac 7,5% and 10% can be an alternative to Paraloid B72 as a wood artifacts consolidation material. Shellac 7,5% is the optimum concentration for wood artifacts consolidation because materials will be more efficient. This material can fill the wood pores and increase the density by 13,89%. The resulting compressive strength value reached 248,01 kg/cm2 or increased by 43,18%, higher than Paraloid B72 10%. Shellac 7,5% does not change the color of the wood and safe from fungal growth when applied to wood. This material also does not change the chemical composition of wood.
Keywords: wood, artifact, consolidation, shellac, gelatin, Paraloid B72
Effectiveness of rebamipide in treatment of erosions in stomach mucosa
Authors: Baryshnikova N. V. , Sousova Ya. V. 
Published: January 2022

The aim. To evaluate the effectiveness of the drug Rebamipide-SZ when used in combination with proton pump inhibitors in the treatment of erosive changes in the gastric mucosa.Materialsandmethods.40patientsweremonitoredwhohaderosivelesionsofthestomach:20patients(group1)witherosivegastritisnotassociatedwithHelicobacterpylori,20patients(group2)witherosivechangesinthegastricmucosawhiletakingnonsteroidalanti-inflammatorydrugs(NSAIDs).Beforethestartoftherapyandaftertheendoftreatment,patientsunderwenta comprehensive examination: assessment of complaints according to the survey data, assessment of the severity of dyspepsia on the GIS scale, assessment of gastroenterological complaints on the GSRS scale, assessment of the effectiveness of treatment on the visual-analog scales of abdominal pain and general well-being, assessment of quality of life (questionnaire SF-36), upper gastro-intestinal endoscopy with biopsy (one biopsy from the stomach body, one biopsy from the antrum of the stomach) for verification of Helicobacter pylori infection (rapid urease test) and histological examination, assessment of side effects. All patients were prescribed therapy: Rebamipide-SZ one tablet three times a day after meals for a month and a proton pump inhibitor (rabeprazole) 20 mg two times a day for 15–30 minutes before meals for a month.Results.There was a complete relief of epigastric pain and a significant decrease or complete relief of dyspeptic complaints. When assessing the dynamics of endoscopic changes after usage of Rebamipide-SZ therapy, there was a regression of hyperemia of the gastric mucosa and complete epithelization of erosions in the stomach in almost all patients. Histological analysis of the gastric mucosa before and after treatment showed a decrease in the severity of acute and chronic inflammatory changes. There were no adverse events, no new complaints, no negative changes in clinical and biochemical blood tests during treatment. No allergic reactions were observed.Conclusion.The intake of Rebamipide-SZ is highly effective and safe for patients with various etiology erosive lesions of the gastric mucosa, including those caused by taking NSAIDs. Rebamipide-SZ can be recommended for course use in the complex therapy of patients with various pathologies of the upper gastrointestinal tract as a gastroprotective agent that helps restore the permeability of the gastric mucosa.
Determinan Sikap Remaja terhadap Pernikahan Dini di Provinsi Banten: Analisis Data SKAP 2019
Authors: Agustin Evi Avicenna , Susanti Sri , Gumilar Rd. Deden 
Published: January 2022

Undang-Undang pernikahan menyebutkan bahwa pernikahan yang ideal untuk laki-laki adalah berusia diatas 21 tahun dan perempuan berusia diatas 19 tahun. Masalah sosial pernikahan usia dini di Indonesia merupakan salah satu fenomena yang banyak terjadi di berbagai wilayah, baik di perkotaan maupun di pedesaan, misalnya tingginya angka perceraian dan kematian ibu dan bayi. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi sikap remaja terhadap pernikahan dini di Provinsi Banten berdasarkan Survey Kinerja dan Akuntabilitas Program tahun 2019. Desain penelitian ini adalah cross-sectional dengan jumlah sampel 1.458. Hasil penelitian menunjukkan ada hubungan antara umur (p=0,001; OR=16,7; 95%CI=12,5-22,4), jenis kelamin (p=0,001; OR=2,51; 95%CI=2,01-3,12), pendidikan (p=0,001; OR=0,09; 95%CI=0,06-0,12), dan pengetahuan (p=0,001; OR=4,11; 95%CI=3,26-5,17) dengan sikap remaja terhadap pernikahan dini. Sedangkan tempat tinggal tidak memiliki hubungan dengan sikap remaja terhadap pernikahan dini (p=0,073). Akses terhadap informasi menjadi isu yang berpengaruh terhadap pengetahuan remaja tentang risiko pernikahan dini sehingga remaja dengan pendidikan rendah dan yang hidup di pedesaan bisa memiliki pengetahuan yang tidak jauh berbeda dengan remaja berpendidikan tinggi dan yang hidup di perkotaan.
Aplikasi Fitofarmaka Akupresur Menggunakan Aromaterapi Essential Oil Lemon untuk Mengatasi Dismenore pada Remaja
Authors: Khotimah Husnul , Subagio Sri Utami 
Published: January 2022

Penanganan dismenore selama ini lebih banyak kepada pemberian terapi farmakologik tetapi jarang menggunakan fitofarmaka seperti akupresur dan aromaterapi. Tujuan penelitian ini adalah untuk menganalisis bagaimana aplikasi akupresur menggunakan aromaterapi essential oil lemon untuk mengatasi nyeri dismenore pada remaja. Jenis penelitian ini adalah penelitian kuantitatif berjenis quasi eksperimen dengan non-equivalent control group design. Populasi dari penelitian ini berjumlah 185. Teknik pengambilan sampel menggunakan pendekatan non-probability sampling (sampling jenuh). Penentuan jumlah sampel dalam peneliti ini memakai perhitungan dari Sastroasmoro & Ismael dengan jumlah sampel 52 terdiri dari 26 kelompok eksperimen dan 26 kelompok kontrol. Analisis data menggunakan Wilcoxon signed rank test untuk menguji masing-masing kelompok eksperimen dan kelompok kontrol dan Mann Whitney untuk membandingkan antara keduanya. Hasil analisis statistik menggunakan Wilcoxon signed rank test pada kelompok eksperimen (p=0,000) dan kelompok kontrol (p=0.000) menunjukkan penggunaan terapi essential oil lemon efektif untuk mengatasi dismenore. Hasil analisis statistik menggunakan Mann Whitney mendapatkan nilai p 0,000 lebih kecil dari tingkat signifikansi 0,05 (p< 0,05). Artinya akupresur menggunakan aromaterapi lebih efektif untuk mengurangi dismenore dibandingkan akupresur saja. Akupresur yang diberikan membuat responden rileks dan imunitas meningkat, ditambah lagi pemijatan menggunakan aromaterapi yang dihirupkan sampai pada paru memberikan manfaat baik secara psikologis dan fisik.
Systematic Characterization of the Group 2 House Dust Mite Allergen in Dermatophagoides microceras
Authors: Hu Rei-Hsing , Wu Chia-Ta , Wu Ting-Shuan , Yu Feng-Yih , Ko Jiunn-Liang , Lue Ko-Huang , Liu Yu-Fan 
Published: January 2022

BackgroundAllergic asthma, a chronic airway inflammatory disease, is a critical public health problem. Indoor house dust mites (HDMs) could cause allergic asthma. The prevalence of sensitization to Dermatophagoides microceras (Der m) was approximately 80% and is related to the immunoglobulin E crossing-reactivity of mites belonging to the same genus, Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farina (Der f). However, studies on Der m are scant.MethodsWe used integrated OMICs approaches to identify and characterize the group 2 mite allergen-like protein in Der m (Der m 2). We established a Der m 2-induced allergic asthma mouse model and treated the mice with a fungal immunomodulatory protein (FIP-fve) isolated from Flammulina veluptipes to evaluate the allergenicity of Der m 2 and the immunomodulatory effects of FIP-fve.ResultsBy performing de novo draft genome assembly and comparative genome analysis, we identified the putative 144-amino acid Der m 2 in silico and further confirmed its existence through liquid chromatography–tandem mass spectrometry. Der m 2 is a lipopolysaccharides (LPS)-binding protein. Thus, we examined the LPS-binding activity of recombinant Der m 2 by performing molecular docking analysis, co-immunoprecipitation (Co-IP), and a pull-down assay. Der m 2 elicited the production of pro-inflammatory cytokines, interleukin (IL)-6, and IL-8 in BEAS-2B cells, a human bronchial epithelial cell line, and induced airway hyperresponsiveness in mice. Furthermore, in mice sensitized with Der m 2, the administration of FIP-fve in either the earlier stage or the late stage, FIP-fve alleviated allergic asthma by moderating airway inflammation and remodeling.ConclusionsDer m 2 induced inflammatory responses in cell and mouse models. FIP-fve alleviated inflammation in Der m 2-induced asthma in mice by exerting an immunomodulatory effect.
Estimating Risk of Cardiovascular Disease Among Long-Term Colorectal Cancer Survivors: A Nationwide Cohort Study
Authors: Jeong Seogsong , Lee Gyeongsil , Choi Seulggie , Kim Kyae Hyung , Chang Jooyoung , Kim Sung Min , Kim Kyuwoong , Son Joung Sik , Cho Yoosun , Park Sang Min 
Published: January 2022

BackgroundConcerns about a growing number of colorectal cancer survivors have emerged regarding cardiovascular disease (CVD) risks. However, there is not yet a predictive tool that can estimate CVD risk and support the management of healthcare as well as disease prevention in terms of CVD risk among long-term colorectal cancer survivors.AimTo develop predictive tools to estimate individualized overall and each subtype of CVD risk using a nationwide cohort in South Korea.Methods and ResultsA total of 4,709 newly diagnosed patients with colorectal cancer who survived at least 5 years in the National Health Insurance System were analyzed. Cox proportional hazard regression was used for the identification of independent risk factors for the derivation of predictive nomograms, which were validated in an independent cohort (n = 3,957). Age, fasting serum glucose, γ-glutamyl transpeptidase, Charlson comorbidity index, household income, body mass index, history of chemotherapy, cigarette smoking, and alcohol consumption were identified as independent risk factors for either overall CVD or each subtype of CVD subtype. Based on the identified independent risk factors, six independent nomograms for each CVD category were developed. Validation by an independent cohort demonstrated a good calibration with a median C-index of 0.687. According to the nomogram-derived median score, relative risks of 2.643, 1.821, 4.656, 2.629, 4.248, and 5.994 were found for overall CVD, ischemic heart disease, myocardial infarction, total stroke, ischemic stroke, and hemorrhage stroke in the validation cohort.ConclusionsThe predictive tools were developed with satisfactory accuracy. The derived nomograms may support the estimation of overall and individual CVD risk for long-term colorectal cancer survivors.
Current Status and Hospital-Level Differences in Care and Outcomes of Patients With Acute Non-ST-Segment Elevation Myocardial Infarction in China: Insights From China Acute Myocardial Infarction Registry
Authors: Zhao Qinghao , Xu Haiyan , Zhang Xuan , Ye Yunqing , Dong Qiuting , Fu Rui , Sun Hui , Yan Xinxin , Gao Xiaojin , Yang Jingang , Wang Yang , Yang Yuejin 
Published: January 2022

BackgroundWith the growing burden of non-ST-elevation myocardial infarction (NSTEMI), developing countries face great challenges in providing equitable treatment nationwide. However, little is known about hospital-level disparities in the quality of NSTEMI care in China. We aimed to investigate the variations in NSTEMI care and patient outcomes across the three hospital levels (province-, prefecture- and county-level, with decreasing scale) in China.MethodsData were derived from the China Acute Myocardial Infarction Registry on patients with NSTEMI consecutively registered between January 2013 and November 2016 from 31 provinces and municipalities throughout mainland China. Patients were categorized according to the hospital level they were admitted to. Multilevel generalized mixed models were fitted to examine the relationship between the hospital level and in-hospital mortality risk.ResultsIn total, 8,054 patients with NSTEMI were included (province-level: 1,698 patients; prefecture-level: 5,240 patients; county-level: 1,116 patients). Patients in the prefecture- and county-level hospitals were older, more likely to be female, and presented worse cardiac function than those in the province-level hospitals (P &lt;0.05). Compared with the province-level hospitals, the rate of invasive strategies was significantly lower in the prefecture- and county-level hospitals (65.3, 43.3, and 15.4%, respectively, P &lt;0.001). Invasive strategies were performed within the guideline-recommended timeframe in 25.4, 9.7, and 1.7% of very-high-risk patients, and 16.4, 7.4, and 2.4% of high-risk patients in province-, prefecture- and county-level hospitals, respectively (both P &lt;0.001). The use of dual antiplatelet therapy in the county-level hospitals (87.2%) remained inadequate compared to the province- (94.5%, P &lt;0.001) and prefecture-level hospitals (94.5%, P &lt;0.001). There was an incremental trend of in-hospital mortality from province- to prefecture- to county-level hospitals (3.0, 4.4, and 6.9%, respectively, P-trend &lt;0.001). After stepwise adjustment for patient characteristics, presentation, hospital facilities and in-hospital treatments, the hospital-level gap in mortality risk gradually narrowed and lost statistical significance in the fully adjusted model [Odds ratio: province-level vs. prefecture-level: 1.23 (0.73–2.05), P = 0.441; province-level vs. county-level: 1.61 (0.80–3.26), P = 0.182; P-trend = 0.246].ConclusionsThere were significant variations in NSTEMI presentation and treatment patterns across the three hospital levels in China, which may largely explain the hospital-level disparity in in-hospital mortality. Quality improvement initiatives are warranted, especially among lower-level hospitals.