bluuebunny/crossref_metadata_2025_split huggingface dataset:
METODOLOGIAS ATIVAS E IMERSIVAS DE APRENDIZAGEM: relato de experiência do curso de Pedagogia
Authors: Camila Tecla Mortean Mendonça  , Gisele Soncini Rodrigues  , João Paulo Bittencourt  , Maria Luísa Furlan Costa  
Published: April 2022

O presente trabalho tem como objetivo apresentar um modelo pedagógico que integra a inovação, as metodologias ativas e imersivas, e as tecnologias na realização de atividades no Curso de Pedagogia, na modalidade de Educação a Distância (EaD), de uma Instituição de Ensino Superior (IES) privada, localizada, geograficamente, no Noroeste do Paraná, bem como suas vantagens enquanto metodologia de ensino. Para tanto, as atividades aplicadas são intituladas como Material de Avaliação Prática de Aprendizagem (Mapa), de maneira a propiciar aos acadêmicos uma experiência pautada nos desafios reais da profissão, centrada, também, na criatividade, no protagonismo e em uma perspectiva de construção do conhecimento, constituindo-se o objeto de estudo da pesquisa. Para a elaboração do trabalho, utilizou-se a pesquisa bibliográfica, com o propósito de entender e esclarecer questionamentos sobre a realidade estudada ao fazer uso de livros e artigos científicos que tratam do tema em foco. Além disso, realizou-se uma pesquisa no Ambiente Virtual de Aprendizagem (AVA) dos alunos do Curso de Pedagogia, com a finalidade de identificar as estratégias metodológicas que contemplem as metodologias ativas e imersivas, proporcionando, dessa forma, uma experiência inovadora por meio da utilização de tecnologias no curso. Concluiu-se que a metodologia utilizada deve favorecer a interação entre teoria e prática, de modo a propiciar ao estudante uma experiência real da profissão.
Palavras-chave: Metodologias ativas e imersivas. Ensino superior. Atividade Mapa. Formação de professor.
Modificación del cabezal de micromotor para una nueva guia quirurgica de implantes: estudio de caso
Authors: Gamarra Ojeda Roxana 
Published: April 2022

Las guías quirúrgicas son dispositivos indispensables para la adecuada colocación de los implantes dentales, siendo la guía quirúrgica generada por ordenador la más precisa, su plano guía está a nivel de la fresa conformadora, esta nueva guía quirúrgica tiene el plano guía a nivel del cabezal del micromotor, es restrictiva en sentido mesiodistal y vestíbulo/palatino-lingual, tiene la ventaja que no interfiere con la refrigeración de la fresa, se adapta a todos los sistemas de implantes, no requiere kits adicionales. Para la fabricación de dicha guía se debe modificar el cabezal del micromotor adicionándole un elemento que le permitirá tener 3 paredes unidas en ángulo de 90 grados, y sobre este se posicionará el riel guía el cual dirigirá la fresas conformadoras del lecho óseo en el grosor óseo del reborde alveolar que la tomografía y la planificación reversa indiquen. En 8 pacientes que requirieron un implante se utilizó la guía propuesta, y a otros 8 se les colocó el implante con la técnica a mano alzada. La guía propuesta mostró desviaciones que fueron de 0 mm a 0,61 mm; las desviaciones con la técnica a mano alzada estuvieron en el rango de 0,58 a 1,56 mm. Estadísticamente no hubo diferencia significativa. La ventaja principal de esta guía es que permite la refrigeración adecuada de la fresa formadora del lecho para el implante, no requiere nuevo kit quirúrgico, es compatible con cualquier sistema; dentro de las desventajas, es que este cabezal debe fabricarse para cada marca de micromotor, aunque el riel guía puede ser el mismo.
A New Look at Landslides of the Vermilion and Echo Cliffs, Northern Arizona
Authors: Watkins Conor M. , Rogers J. David 
Published: April 2022

ABSTRACT
The Vermilion and Echo Cliffs form a nearly continuous escarpment more than 160 km long within the Colorado Plateau physiographic province of North America. The cliffs overlie the Marble Platform in northern Arizona and are located along the Colorado River, just upstream of the Grand Canyon. Large rotational block landslides mantle the erosional escarpment along most of its extent. Although these landslides have been noted for over 100 years, their likely origin has never been explained. Landslide failure surfaces appear to be influenced by the Petrified Forest Member of the Triassic Chinle Formation, a shale layer containing smectite clay weathered from volcanic ash. Although landslides are common along the majority of escarpments comprising the Colorado Plateau where the Petrified Forest Member and other shales outcrop, most appear to have been inactive since the early Holocene. Multiple generations of landslides and remnants of previous slides exist up to 3 km from the present cliff face. Multiple working hypotheses explaining these landslides are explored in this article, including past landslides and/or lava dams along the Colorado River within the Grand Canyon, periods of wetter climate with higher groundwater levels, and earthquakes related to nearby faulting and volcanism. Various sliding modes along these cliffs are described along with potential triggering mechanisms. Back-analysis of these landslides has been conducted using mechanical properties of the formations involved as well as varying groundwater levels. Calculated factors of safety for existing slides under present conditions are greater than unity, consistent with their apparent stability.
The Conflict with non-HRM Department: Reason, Mediation, Result
Authors: Chen Zhisheng 
Published: April 2022

Abstract
When the human resources department implements human resources policies and systems, there will be various obstacles from other departments. Because human and non-human departments are different in departmental goals and division of tasks, conflicts in human resource management are likely to occur, which affects the realization of organizational goals. This article constructs a conflict model between the two parties and studies the origin of the conflict between the HRM and non-HRM sectors, including personnel, policies, and systems. It also proposes ways to resolve conflicts, such as communication, role exchange, business process consensus, focus on organizational goals, and political skills. After the conflict between the two parties is resolved, it is beneficial to achieve a win-win result for employees, departments, and organizations.
Safety analysis of immunochemotherapy combined with consolidative thoracic radiotherapy for extensive-stage small cell lung cancer
Authors: Li Yuying , Jing Xuquan , Chang Jiayu , Li Jiatong , Zhang Yan , Guo Jun , Tang Xiaoyong , Zhu Hui 
Published: April 2022

Abstract
Background: Thoracic radiation therapy (TRT) has been shown to improve local tumour control and provide survival benefits for patients with extensive-stage small cell lung cancer (ES-SCLC) in the era of chemotherapy. However, there are no data to indicate the safety, especially the lung toxicity, of TRT during and following the administration of four cycles of programmed death ligand 1 (PD-L1) inhibitors when used with etoposide and platinum (EP). Hence, this retrospective study aimed to investigate the risk factors for radiation pneumonitis (RP) associated with TRT combined with PD-L1 inhibitors.Methods: From January 2020, through March 2021, in Shandong Cancer Hospital and Institute, patients with ES-SCLC who received TRT during maintenance with PD-L1 inhibitors combined with EP were enrolled in this retrospective study. RP was investigated and evaluated according to the Common Terminology Criteria for Adverse Events version 5.0 (CTCAE v5.0) criteria. We used univariate and multivariate logistic regression to analyse the potential risk factors for RP.Results: From January 2020, to March 2021, 20 patients receiving TRT during maintenance with PD-L1 inhibitors combined with EP were enrolled in this retrospective study. The dose fractions were 1.5 Gy bid or 1.8-3 Gy qd, and the total dose was 30 Gy to 61.4 As a result, 6 patients (30%) experienced grade 2 RP, and no cases of ≥3 grade RP occurred. At the last follow-up, 17 patients suffered from disease progression, 13 suffered from distant progression, three suffered from local failure in the radiation field, and one suffered from distant progression and local failure in the radiation field. The median progression-free time (PFS) was 9 months.Conclusion: The retrospective analysis showed that the lung toxicity resulting from TRT was tolerable during maintenance with PD-L1 inhibitors combined with EP.
HDAC10-mediated acetylation of COX5A promotes inflammatory responses of silica- treated macrophages in silicosis via the ROS/NF-κβ/TNF-α pathway
Authors: Li Shao-min , Zhao Feng , Zhu Min-xia , Zhao Wen , Xie Rong-xing , Shi Hong-yang , Li Jian-zhong 
Published: April 2022

Abstract
BackgroundSilicosis is pneumoconiosis of the lung, which usually results from prolonged exposure to and inhalation of silicon dioxide. Currently an effective treatment for silicosis is lacking. The hallmark of silicosis is chronic inflammation of silica-treated macrophages. However, the detailed molecular mechanism underlying silicosis remains elusive. MethodsSilicotic rats were established by a single intratracheal instillation of silica suspension. The lung tissues from silicotic and control rats were obtained for pathological observation, transcriptome sequencing, tandem mass tag quantitative proteomic analysis and quantitative proteome detection by acetylation modification. We further examined silica-treated macrophage-derived inflammation and the underlying molecular mechanism using siRNAs and overexpression plasmids in vitro.Results Transcriptome sequencing revealed downregulated expression of histone deacetylase 10 (HDAC10) in lungs from silicotic rats. Knockdown of HDAC10 enhanced the acetylation level of cytochrome oxidase 5A(COX5A) in rat silicosis tissue and increased reactive oxygen species (ROS), which led to increased secretion of inflammatory factors and chemokines from silica-treated macrophages. High acetylation of COX5A aggravated silica-treated macrophage-derived inflammation by the ROS/NF-κb/TNF-α pathway.ConclusionOur results indicate that HDAC10 mediates silica-treated macrophage-derived inflammation by the ROS/NF-κb/TNF-α pathway. Targeting this pathway may help improve silicosis and represents a potential therapeutic strategy to reduce inflammation and potentially treat silicosis.
Extremely short 3D Bessel pulses in an optically anisotropic photonic crystal made from CNTs with account for nonlinear absorption and pumping
Authors: Zhukov Alexander V. , Bouffanais Roland , Dvuzhilov Ilya S. , Dvuzhilova Yulia V. , Belonenko Mikhail B. 
Published: April 2022

Abstract
We present a theoretical and numerical study of the dynamics of diffractionless three-dimensional (3D) extremely short optical pulses with a Bessel cross-section in an optically anisotropic medium with a spatially modulated refractive index (known as photonic crystal) based on carbon nanotubes of the zigzag type. The nonlinear absorption is taken into account based on experimental data, as well as the effects associated with the external pump field. Through numerical simulations, it was found that in such an optically anisotropic photonic crystal, Bessel pulses propagate stably over times of several dispersion lengths, while dissipative solitons arise during the evolution of pulses. The influence of the parameters of the anisotropic photonic crystal—e.g., the depth and period of modulation of the refractive index and anisotropy parameters—on the evolution of pulses, in particular, their shape and group velocity, is established.
Determination of Cadmium in Chinese pepper and its health implications based on bioaccessibility
Authors: Wang Zelan , Yao Jie , Tu Chenglong , Yang Ting , Sun Dali , Lin Changhu 
Published: April 2022

Abstract
The contamination of Cadmium (Cd) in agro-products causes major concern because of its potential dietary risks. In this study, 647 pepper samples from 21 provinces in China were randomly collected according to the distribution of pepper production. Based on the data of Cd contents in pepper and the bioaccessibility measured by the physiologically-based extraction test (PBET), the contamination levels and health risks of Chinese pepper were accurately evaluated. The results showed that Cd concentration in all pepper ranged from 0.002 to 1.470 mg/kg, with an average of 0.222 mg/kg and a median of 0.132 mg/kg. The highest daily intake of Cd (4.037×10− 5 mg/kg bw/day) was observed in female child group which accounted for 4% of the maximum daily permissible dose − 0.001mg/kg bw/day. The target hazard quotients of Cd were all lower than 1, indicating low potential non-carcinogenic health risk to residents via the consumption of pepper. Notably, carcinogenic risk values suggested potential adverse health effects to adults, while after considering the bioaccessibility of Cd in pepper (mean of 43.07%), those values had fallen under the acceptable level (1×10− 4). This may indicate that dietary risk assessment of heavy metals in crops could not be conducted just based on their content, the bioaccessibility of metals is also an important factor for consideration.
Regarding our manuscript: Tim-3-immune checkpoint receptor expression on CD4+ and CD8+ T cells and rheumatoid arthritis disease activity
Authors: Soliman Tamer M. , AbuAlFadl Esam M. , Radwan Ahmed , Amrosy Yasmine M. , El-kannishy Sherif M. H. , Elmansoury Eman , Aboelnour Alaa , Ahmed Heba A. 
Published: April 2022

Abstract
Background
Rheumatoid arthritis (RA), is a chronic inflammatory autoimmune disease, characterized by dysregulated T cell immune response..
Objective
To investigate the Tim-3 surface expression on peripheral blood CD4+ and CD8+ T cells in RA patients concerning disease activity.
Methods
A cross-sectional case-controlled study involving 157 RA patients who were categorized by disease activity score 28 (DAS28) into 4 groups; patients with remission and low, moderate, and high RA activity groups. The assessment of Tim-3 expression on peripheral CD4 and CD8 T cells of patients and controls using flow cytometry was done.
Results
The peripheral expression of Tim-3 on CD4 + and CD8 + T cells was significantly higher in RA patients as compared to controls (for CD4 + T cells, 3.55 ± 1.12% in remission group vs. 1.21 ± 0.52 in control group, p < 0.001; for CD8 + T cells, 5.95 ± 1.49% in remission group vs. 1.80 ± 0.73% in control group, p < 0.001). There was an inverse correlation between percentages of both peripheral Tim-3 + CD4 + and Tim-3 + CD8 + T cell and RA DAS28, (r = − 0.425, p = 0.001) and (r= − 0.597, p = < 0.001) respectively.
Conclusion
The upregulated Tim-3 expression on peripheral CD4 + and CD8 + T-cells suggests a potential role of this immune checkpoint receptor in T cell immune dysregulation in RA. Tim-3 expression was negatively correlated with disease progression. Tim-3 could be a useful biomarker in determining the rheumatoid disease activity, progression, and represents an important target for inhibitors intervention in RA.
Space-time analyses of sediment composition reveals synchronized dynamics at all intertidal flats in the Dutch Wadden Sea
Authors: Folmer Eelke O. , Bijleveld Allert I. , Holthuijsen Sander , Meer Jaap , Piersma Theunis , Veer Henk W. 
Published: April 2022

Abstract
Intertidal mudflat systems are shaped by geological processes and an interplay of hydrodynamics, sediment availability and ecological processes. All around the world these systems are affected by relative sea level rise (RSLR), changing climate and by human activities such as sediment nourishments, dredging, hydrological engineering and bottom trawling. These kinds of perturbations cause changes in morphology and sediment composition which may cause shifts in the composition, spatial distribution and productivity of benthic communities. We analyzed the spatial and temporal variability of the sediment grain size of almost 1200 km2 intertidal flats in the Dutch Wadden Sea in the period 2009-2019. The large scale coverage was achieved by yearly grid sampling at more than 4000 stations. Spatial paneldata models were used to analyse changes in median grain size and mud content between years and to estimate the effects of resuspension due to wind and the accumulation of silt during summer. We show that between years the sediments of the intertidal flats changed synchronously throughout the study area and that the flats became coarser during the period 2011-2015 and muddier again between 2015 and 2019. The system wide changes and the absence of clear local deviations leads to the hypothesis that a large scale factor like RSLR, variability in the composition of suspended sediment in the North Sea, changing microphytobenthic productivity, or sediment nourishments in the coastal zone were causally involved in the coarsening of intertidal flats. Our data and analysis provides a base for further scientific enquiry but longer time series on higher temporal resolution of both sediment data and the physical and ecological environment are required. Models simulating the environment may provide further insight into possible development of sediment composition of the intertidal flats of the Wadden Sea.
Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
Authors: Joachimiak Lukasz , Osipiuk Jerzy , Wydorski Pawel , Lanham Benjamin , Tesar Christine , Endres Michael , Engle Elizabeth , Jedrzejczak Robert , Mullapudi Vishruth , Michalska Karolina , Fidelis Krzysztof , Fushman David , Joachimiak Andrzej 
Published: April 2022

Abstract
The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational conjugates with poly-ubiquitin and protective ISG15, composed of two ubiquitin-like (UBL) domains. Across coronaviruses, PLpro showed divergent selectivity for recognition and cleavage of posttranslational conjugates despite sequence conservation. We show that SARS-CoV-2 PLpro binds human ISG15 and K48-linked di-ubiquitin (K48-Ub2) with nanomolar affinity and detect alternate weaker-binding modes. Crystal structures of untethered PLpro complexes with ISG15 and K48-Ub2 combined with solution NMR and cross-linking mass spectrometry revealed how the two domains of ISG15 or K48-Ub2 are differently utilized in interactions with PLpro. Analysis of protein interface energetics uncovered differential binding stabilities of the two UBL/Ub domains. We emphasize how substrate recognition can be tuned to cleave specifically ISG15 or K48-Ub2 modifications while retaining capacity to cleave mono-Ub conjugates. These results highlight alternative druggable surfaces that would inhibit PLpro function.
The use of two Comfort YCFs in the dietary management of toddlers with a history of functional constipation: a randomized controlled trial
Authors: Fernández Miriam Contreras , Es Joshué David Covarrubias , Sevilla Daniel Alfonso Cisneros , Hofman Denise , Kudla Urszula , Ángel Darelia Alelí Topete , Madero Sergio Díaz 
Published: April 2022

Abstract
Background: Pharmacological intervention with laxatives is the conventional treatment for functional constipation. Data to support the dietary management of functional constipation is lacking. This study compared the efficacy of two Comfort young child formulas with regards to the maintenance of healthy stooling parameters in toddlers with a history of constipation. It was registered in the Netherlands Trial Registry [identifier: NL7420 (NTR7653)], registration date 20/09/2018. Methods: Ninety-five healthy toddlers, aged 12 to 32 months, diagnosed with functional constipation (Rome III criteria) were randomized to receive one of two study formulas after pharmacological treatment. For the first month of the intervention, subjects received a laxative in a decreasing maintenance dose alongside a test or control formula (maintenance phase). Subsequently, subjects only consumed formula for another month (post-maintenance phase). Stooling parameters were obtained weekly using the Bristol Stool Scale and modified Rome III Questionnaire on Paediatric Gastrointestinal Symptoms for infants and toddlers. Differences in percentages of hard stools (primary outcome) and other stooling parameters were analysed using analysis of covariance and Chi-Square methods. Results: The overall percentage of hard stools was 5.02% in the test and 2.98% in the control group (n.s.). In the test group, these percentages dropped from 7.11% at the end of the maintenance phase, to 3.92% at the end of the post-maintenance phase (n.s.). In contrast, the % of hard stools in the control group was similar at the end of the maintenance (3.11%) and post-maintenance phase (2.77%; n.s.). No difference was found in the overall stool frequency between groups.At the end of the maintenance phase, only 22% and 19% of toddlers consuming the test and control formulae, respectively, met 2 or more of the criteria for functional constipation. At the end of the study, this percentage decreased to 9% in the test group (p=0.057), whereas it remained similar in the control group (21%, p=0.1). The number needed to treat for functional constipation was 8.3 in favour of the test formula at the end of the study period. No laxative use was reported in either study group during the post-maintenance phase. Conclusion: Both Comfort YCF support the maintenance of improved stooling over time in toddlers with a history of constipation. Children receiving the formula with intact protein tended to meet lower numbers of indicators of FC at the end of the study.
Conventional versus modified application of COOK Cervical Ripening Balloon for induction of labor at term: a randomized controlled trial
Authors: Wen Chaoyue , Liu Xuemin , Wang Ying , Wang Jun 
Published: April 2022

Abstract
Background
This study aims to evaluate the efficacy and safety of the modified application of COOK Cervical Ripening Balloon (CCRB) for induction of labor (IOL) at term in primipara.
Methods
A total of 227 singleton full-term pregnancies with indications of IOL were enrolled and randomly divided into the control and study groups in our hospital from January 2021 to December 2021. In the control group, a conventional method was used. Both the uterine and vaginal balloons were filled to 80 mL and removed after 12 hours. In the study group, a modified method was used. The uterine and vaginal balloons were filled to 120 mL and 40 mL respectively. Small weight traction was given to help CCRB discharged after 12 hours placement. Oxytocin was administered in both groups after CCRB was discharged without labor starting. The improved Bishop scores, duration of labor, and spontaneous delivery rate were evaluated in the two groups.
Results
The improved Bishop scores in the study group were 3.06 ± 0.97 at 12 hours placement of CCRB and 4.37 ± 0.87 when CCRB was discharged, which were significantly higher than 2.52 ± 0.79 in the control group (p < 0.05). The first and total stages of labor in the study group were significantly shorter than those in the control group ((6.17 ± 2.85) h vs. (7.27 ± 2.90) h, p = 0.010; (7.07 ± 3.18) h vs. (8.09 ± 3.11) h, p = 0.028). No difference in spontaneous delivery rate between the two groups was observed. But the delivery rate within 24h between the two groups had a significant difference (79.79% vs. 55.91%, p < 0.05). For the cases with initial Bishop scores ≤ 3, the improved score was significantly increased, the first and total stages of labor were significantly shorter in the study group than those in the control group (p < 0.05). Those