bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conservation of an Agrobacterium cT-DNA insert in Camellia section Thea reveals the ancient origin of tea plants from a genetically modified ancestor
Authors: Chen Ke , Zhurbenko Peter , Danilov Lavrentii , Matveeva Tatiana , Otten Léon 
Published: December 2022

IntroductionMany higher plants contain cellular T-DNA (cT-DNA) sequences from Agrobacterium and have been called “natural genetically modified organisms” (nGMOs). Among these natural transformants, the tea plant Camellia sinensis var. sinensis cv. Shuchazao contains a single 5.5 kb T-DNA fragment (CaTA) with three inactive T-DNA genes, with a 1 kb inverted repeat at the ends. Camellia plants are allogamous, so that each individual may contain two different CaTA alleles.Methods142 Camellia accessions, belonging to 10 of 11 species of the section Thea, were investigated for the presence of CaTA alleles.Results discussionAll accessions were found to contain the CaTA insert, showing that section Thea derives from a single transformed ancestor. Allele phasing showed that 82 accessions each contained two different CaTA alleles, 60 others had a unique allele. A phylogenetic tree of these 225 alleles showed two separate groups, A and B, further divided into subgroups. Indel distribution corresponded in most cases with these groups. The alleles of the different Camellia species were distributed over groups A and B, and different species showed very similar CaTA alleles. This indicates that the species boundaries for section Thea may not be precise and require revision. The nucleotide divergence of the indirect CaTA repeats indicates that the cT-DNA insertion took place about 15 Mio years ago, before the emergence of section Thea. The CaTA structure of a C. fangchengensis accession has an exceptional structure. We present a working model for the origin and evolution of nGMO plants derived from allogamous transformants.
Associations between parental mediation and adolescents' internet addiction: The role of parent–child relationship and adolescents' grades
Authors: Li Xiaojing , Ding Ying , Bai Xianchun , Liu Lisha 
Published: December 2022

IntroductionFamily factors, such as parental mediation on Internet use and parent-child relationships, have been shown to play a crucial role in preventing adolescents' internet addiction. Previous studies have shown a change in characteristics of online risk during adolescents' development. However, it is still of great interest whether such differences applied in the relationships among parent-child relationships, different types of parental mediation and adolescents' internet addiction level. In this study, we investigated the associations between different types of parental mediators and adolescents' internet addiction level and how the associations were mediated by father-child and mother-child relationships. We further investigated whether mediating effect differs between primary and secondary school children.MethodsBased on a sample of 3,026 school children aged 9–14 years (M = 11.56, SD = 0.71; 55.25% primary school adolescents, 44.75% secondary school adolescents), a series of Structural Equation Models were applied to investigate the relationships among internet addiction, parental mediation, and parent-child relationship. In addition, a series of multi-group analysis were applied to detect whether there are differences in these relationships between the primary and secondary school group.ResultsThe internet addiction level and intensity of parental mediation was higher among primary school adolescents than secondary school adolescents. Parental active mediation and monitoring on internet use were associated with reduced and increased adolescents' internet addiction. Father-child relationship had stronger partial mediating effects on the relationships between parental mediation and adolescents' internet addiction than the mother-child relationship. The relationships among parental mediation, parent-child relationship and internet addiction were more pronounced among primary school adolescents than secondary school adolescents.DiscussionThe findings suggest that good father-child relationships and adequate parental mediation approach, such as active mediation, may contribute to reduction of internet addiction risk in adolescents, especially in primary school adolescents.
Motoric performance variation from morning to evening: 80% intensity post-activation potentiation protocol impacts performance and its diurnal amplitude in basketball players
Authors: Eken Özgür , Mainer-Pardos Elena , Yagin Fatma Hilal , Eken Ismihan , Prieto-González Pablo , Nobari Hadi 
Published: December 2022

IntroductionPost-activation potentiation (PAP) can be defined as the acute enhancement in muscle performance after preload stimulation that occurs during strength exercises or warm-up protocols, and the contractile history of any muscle group can directly influence the presented performance. The purpose of this study was to compare the results of motoric performance tests carried out at two different times of the day using three different PAP protocols.MethodsThirty-two male basketball players with at least 2 years of training experience and who competed at the national level were recruited for this study [age: 21.80 ± 1.91 years; body height: 178.40 ± 6.85 cm; body mass: 72.50 ± 7.16 kg; body mass index (BMI): 22.81 ± 2.28]. After control and experimental-specific warm-up (SWU) sessions, participants completed a countermovement jump (CMJ) and seated medicine ball throw (SMBT). The SWU protocol was developed based on the athlete’s typical warm-up routine. The experimental warm-ups included the same exercises as the SWU, with one set of bench presses for five repetitions at 80% (80% PAP) and one repetition at 100% of 1 RM (100% PAP). Each of the protocols consists of 15 min. The SWU and experimental warm-up sessions were completed in a random, counterbalanced order, completed in a period of 3-weeks.ResultsAccording to the research findings, carrying out the protocols in the evening led to a larger improvement in SMBT than in the morning (F = 35.94, p &lt; 0.001, η2p = 0.537). Additionally, the SMBT results were statistically more significant in the group that received 80% PAP compared to the SWU (p = 0.034), and the SMBT results were also higher in the group that received 100% PAP compared to the SWU (p = 0.002). Furthermore, the interaction effect (time × PAP) was statistically significant in SMBT (F = 6.39, p = 0.003, η2p = 0.17).DiscussionThese results may provide more particular recommendations than previously thought to basketball coaches for the planning of basketball-specific PAP exercises prior to the start of training programs.
Which outcome variables are associated with psychological inflexibility/flexibility for chronic pain patients? A three level meta-analysis
Authors: Fang Shuanghu , Ding Dongyan 
Published: December 2022

The psychological flexibility model can be seen as a basis for an integrated and progressive psychological approach to chronic pain management. Some researchers suggest that psychological flexibility and inflexibility represent distinct processes and constructs. This meta-analysis is the first to provide a summary estimate of the overall effect size for the relationship between psychological (in)flexibility and common outcomes among chronic pain patients. The research protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, https://www.crd.york.ac.uk/PROSPERO/), registration number CRD42021285705. Four databases were searched (PsycINFO; PubMed; Web of Science, CINAHL) along with reference lists. Thirty-six cross-sectional studies were included (7,779 participants). Meta-analyses (random effects model) indicated a significant medium negative association between psychological flexibility and pain intensity or functional impairment. The present study also indicated a significant small to medium association between psychological inflexibility and pain intensity, a nearly large association between psychological inflexibility and functional impairment as well as the quality of life, and a large association between psychological inflexibility and anxiety/depression. Due to the limited number of included studies, the relationship between risk behavior and psychological inflexibility may not be significant. Types of countries and instruments measuring psychological inflexibility may explain part of the heterogeneity. These findings may carry significant implications for chronic pain patients regarding the potential relationship between psychological inflexibility or flexibility and these outcomes. It may consequently form the basis for more robust testing of causal and manipulable relationships.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021285705.
The sibling effect on neurodevelopment of preschoolers under China’s newly relaxed child policy: A national retrospective cohort study
Authors: Dai Xiaotian , Williams Gareth , Lin Senran , Baker Charlie , Wu Meiqin , Du Wenchong , Hua Jing 
Published: December 2022

IntroductionThe change in Chinese fertility policy brings new challenges and considerations for children’s health outcomes; however, very little is known about the interaction between siblings, family socioeconomic status (SES), and neurodevelopment in the Chinese preschool-age population. Therefore, this study aimed to develop a new explanatory pathway from sibling effect to early childhood development and explored the mediation effect of family SES in the pathway.MethodsFrom April 2018 to December 2019, we conducted a national retrospective cohort study in 551 cities in China, and a total of 115,915 preschool-aged children were selected for the final analysis. Children’s neurodevelopment, including Communication, Gross motor, Fine motor, Problem-solving, and Personal-social, was assessed with the Ages &amp; Stages Questionnaires, Third Edition (ASQ-3). Hypothesis tests and multilevel regression models were used to assess the associations and their strength between sibling effect and neurodevelopmental delay. Pathway analysis was used to verify the mediation effect of SES.ResultsThe results showed that there were significant risk effects of a sibling on preschoolers’ overall neurodevelopment including communication, gross motor, fine motor, and problem-solving delay. The adjustment of family SES, however, brought a reversal of this association. The results of the mediation model illustrated a direct, protective effect of one-sibling status (βASQ-delay = −0.09; βASQ-scores = 0.07; p &lt; 0.001), and an indirect, risk effect from one-sibling status through family SES to neurodevelopment outcomes (βASQ-delay =0.12; βASQ-scores = −0.12; p &lt; 0.001). The total sibling effect was weakened but remained negative (βASQ-delay =0.03; βASQ-scores = −0.05; p &lt; 0.001).DiscussionThis study concluded that family SES mediated the negative effects of one sibling on early child development. To enhance the positive influence of sibling addition, we suggested providing more resources and instructions to the families with less educated and poorer employed parents under the coming multi-child era.
Does central executive training and/or inhibitory control training improve emotion regulation for children with attention-deficit/hyperactivity disorder? A randomized controlled trial
Authors: Groves Nicole B. , Chan Elizabeth S. M. , Marsh Carolyn L. , Gaye Fatou , Jaisle Emma M. , Kofler Michael J. 
Published: December 2022

IntroductionApproximately 48–54% of children with attention-deficit/hyperactivity disorder (ADHD) have impairing difficulties with emotion regulation, and these difficulties are not ameliorated by first-line ADHD treatments. Working memory and inhibitory control represent promising intervention targets given their functional, if not causal, links with ADHD-related emotion dysregulation.MethodsThis preregistered randomized controlled trial tested whether two digital therapeutic training protocols that have been previously shown to improve working memory (Central Executive Training [CET]) and inhibitory control (Inhibitory Control Training [ICT]) can improve emotion regulation in a sample of 94 children with ADHD aged 8–13 years (M = 10.22, SD = 1.43; 76% White/non-Hispanic; 29 girls).ResultsResults of Bayesian mixed model ANOVAs indicated both treatment groups demonstrated significant decreases in emotion dysregulation relative to pre-treatment at immediate post-treatment (parent report; d = 1.25, BF10 = 8.04 × 1013, p &lt; 0.001), at 1–2 months after completing treatment (teacher report; d = 0.99, BF10 = 1.22 × 106, p &lt; 0.001), and at 2–4-months follow-up (parent report; d = 1.22, BF10 = 1.15 × 1014, p &lt; 0.001). Contrary to our hypotheses, the CET and ICT groups demonstrated equivalent reductions in emotion dysregulation and maintenance of effects. Exploratory analyses revealed that results were robust to control for informant expectancies, ADHD medication status/changes, in-person vs. at-home treatment, child age, and time from treatment completion to post-treatment ratings.DiscussionTo determine whether working memory and inhibitory control are causally linked with ADHD-related emotion dysregulation, future studies should include active control conditions that do not train executive functions prior to making decisions about the clinical utility of CET/ICT for the treatment of emotion dysregulation in ADHD.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT03324464].
Cross-lagged relationship between anxiety, depression, and sleep disturbance among college students during and after collective isolation
Authors: Shi Congying , Wang Shujian , Tang Qihui , Liu Xiangping , Li Yue 
Published: December 2022

ObjectRepeated quarantine policies over the past 3 years have led to poor psychological consequences for the public. Previous studies have proved that the quarantine policy leaves individuals vulnerable to anxiety, depression, and insomnia, especially among college students. This study aims to explore whether psychological problems during isolation continue with the release of isolation.MethodsOverall, 2,787 college students both answered a web-based survey during and after the closure management was lifted. The Patient Health Questionnaire, Generalized Anxiety Disorder Scale, and Youth Self-rating Insomnia Scale were measured. The cross-lagged path model was used to explore the influence of psychological impact during isolation on the individual after the release.ResultsWe found that anxiety and sleep disturbance levels alleviated significantly after quarantine, except for depression. As expected, a bidirectional relationship exists between anxiety, depression, and sleep disturbance. Moreover, depression and sleep disturbance can predict post quarantine depression, sleep disturbance, and anxiety, yet anxiety cannot predict sleep disturbance afterward.ConclusionTimely and effective intervention for anxiety, depression, and insomnia during isolation is essential for individuals to repair themselves quickly after the release.
“We need to talk to each other”: Crossing traditional boundaries between public health and occupational health to address COVID-19
Authors: Hopwood Pamela , MacEachen Ellen , Majowicz Shannon E. , Meyer Samantha B. , Amoako Joyceline 
Published: December 2022

IntroductionThis study examined how public health (PH) and occupational health (OH) sectors worked together and separately, in four different Canadian provinces to address COVID-19 as it affected at-risk workers. In-depth interviews were conducted with 18 OH and PH experts between June to December 2021. Responses about how PH and OH worked across disciplines to protect workers were analyzed.MethodsWe conducted a qualitative analysis to identify Strengths, Weakness, Opportunities and Threats (SWOT) in multisectoral collaboration, and implications for prevention approaches.ResultsWe found strengths in the new ways the PH and OH worked together in several instances; and identified weaknesses in the boundaries that constrain PH and OH sectors and relate to communication with the public. Threats to worker protections were revealed in policy gaps. Opportunities existed to enhance multisectoral PH and OH collaboration and the response to the risk of COVID-19 and potentially other infectious diseases to better protect the health of workers.DiscussionMultisectoral collaboration and mutual learning may offer ways to overcome challenges that threaten and constrain cooperation between PH and OH. A more synchronized approach to addressing workers' occupational determinants of health could better protect workers and the public from infectious diseases.
The evolution of research on depression during COVID-19: A visual analysis using Co-Occurrence and VOSviewer
Authors: Fu Qiannan , Ge Jiahao , Xu Yanhua , Liang Xiaoyu , Yu Yuyao , Shen Suqin , Ma Yanfang , Zhang Jianzhen 
Published: December 2022

BackgroundThe COVID-19 pandemic has led to public health problems, including depression. There has been a significant increase in research on depression during the COVID-19 pandemic. However, little attention has been paid to the overall trend in this field based on bibliometric analyses.MethodsCo-Occurrence (COOC) and VOSviewer bibliometric methods were utilized to analyze depression in COVID-19 literature in the core collection of the Web of Science (WOS). The overall characteristics of depression during COVID-19 were summarized by analyzing the number of published studies, keywords, institutions, and countries.ResultsA total of 9,694 English original research articles and reviews on depression during COVID-19 were included in this study. The United States, China, and the United Kingdom were the countries with the largest number of publications and had close cooperation with each other. Research institutions in each country were dominated by universities, with the University of Toronto being the most productive institution in the world. The most frequently published author was Ligang Zhang. Visualization analysis showed that influencing factors, adverse effects, and coping strategies were hotspots for research.ConclusionThe results shed light on the burgeoning research on depression during COVID-19, particularly the relationship between depression and public health. In addition, future research on depression during COVID-19 should focus more on special groups and those at potential risk of depression in the general population, use more quantitative and qualitative studies combined with more attention to scale updates, and conduct longitudinal follow-ups of the outcomes of interventions. In conclusion, this study contributes to a more comprehensive view of the development of depression during COVID-19 and suggests a theoretical basis for future research on public health.
The mediating role of physical activity and sedentary behavior in the association between working from home and musculoskeletal pain during the COVID-19 pandemic
Authors: Loef Bette , van Oostrom Sandra H. , Bosma Esmee ,   Lifelines Corona Research Initiative, Proper Karin I. 
Published: December 2022

IntroductionWorking from home during the COVID-19 pandemic has been associated both with physical inactivity and musculoskeletal pain. However, it has not been examined whether physical activity and sedentary behavior are underlying mechanisms in the association between working from home and musculoskeletal pain. Therefore, we examined their mediating role in this association.MethodsData were used from 24 questionnaire rounds of the Lifelines COVID-19 cohort (March 2020–January 2022). Longitudinal information on work situation (location, home, hybrid), physical activity, sedentary behavior, and musculoskeletal pain was collected among 28,586 workers. Analysis of physical activity/sedentary behavior as mediators of the association between working from home and musculoskeletal pain was performed using multilevel structural equation modeling.ResultsHome workers more often had pain in the upper back [odds ratio (OR) = 1.17, 95%-confidence interval (CI) = 1.02–1.34] and arm, neck, and/or shoulder (ANS) (OR = 1.32, 95%-CI = 1.19–1.47) than location workers. Furthermore, home workers were more often sedentary for &gt;9 h per work day than location workers (OR = 2.82, 95%-CI = 2.56–3.09), and being more sedentary was associated with musculoskeletal pain (upper back: OR = 1.17, 95%-CI = 1.06–1.30; ANS: OR = 1.25, 95%-CI = 1.16–1.34). Corresponding indirect effects were OR = 1.18 (95%-CI = 1.04–1.33) and OR = 1.26 (95%-CI = 1.12–1.35). No indirect effect was found for physical activity. Similar indirect effects were observed for hybrid workers.ConclusionHome and hybrid workers were more likely to have pain in the upper musculoskeletal system during the COVID-19 pandemic than location workers, which was partly mediated by increased sedentary behavior, but not by reduced physical activity. Measures to reduce sedentary time in home workers may contribute to preventing musculoskeletal pain.
Addressing violence against children: A case review in the state of Qatar
Authors: Al-Mohannadi Abdulla Saeed , Al-Harahsheh Sanaa , Atari Sajeda , Jilani Nadeem , Al-Hail Ghalya , Sigodo Kennedy 
Published: December 2022

IntroductionViolence against children (VAC) is a critical public health issue that affects billions of children worldwide. The combination of its prevalence and severity of effects on children creates an urgent need for effective interventions. Multiple studies associate VAC with lifelong implications that affect children through adulthood. In Qatar, multiple approaches such as legislation are being used to protect children from all forms of violence. Despite the gravity of the issue, there is still low readiness for the prevention of VAC in Qatar. This review aimed to map approaches to addressing VAC in Qatar from the panelists' perspectives on current approaches to addressing VAC.MethodsThe review obtained data from a recorded video entitled “A Public Health Approach to Addressing Violence Against Children.” The panel discussion in this video clip was organized as a side event of the WISH virtual summit by UNICEF and WISH on World Children's Day, held in Qatar in November 2020. The video was transcribed and analyzed using thematic analysis.FindingsIt shows the importance of both global and national level interventions in addressing VAC. The review uses the socioecological model to show relationships among different levels of interventions addressing VAC in Qatar. The findings highlight the national approaches to addressing VAC using public health, and legislative and policy approaches.DiscussionThe interventions addressing VAC at different levels in Qatar are interconnected. Delineating each level is key to the formation of holistic interventions that leverage global, regional, national, communal, familial, and individual factors that support interventions to address VAC.