bluuebunny/crossref_metadata_2025_split huggingface dataset:
How we approach lymphedema in the pediatric population
Authors: Pateva Irina , Greene Arin K. , Snyder Kristen M. 
Published: April 2022

AbstractLymphedema in children is rare; however, it is usually a progressive and chronic condition. Accurate diagnosis of lymphedema in the pediatric population often takes several months and sometimes is delayed for years. Lymphedema can be isolated or associated with genetic syndromes, thus it is very important to identify the correct diagnosis, to select carefully which patients to refer for genetic testing, and to initiate appropriate treatment in a timely fashion. In this article, we review key information about diagnosis of lymphedema, associated conditions and syndromes, and current treatment modalities.
Integration of physical health and sensory processing assessment for children with autism spectrum disorder in schools
Authors: Trudel Sierra M. , Winter Emily L. , Fitzmaurice Brenna , Norman Gina , Bray Clark R. 
Published: April 2022

AbstractIndividuals with autism spectrum disorder (ASD) often undergo various assessments and evaluations as part of the diagnostic process, identification and classification for special education eligibility, and continued progress monitoring for skill growth. Such evaluations may include cognitive, social and emotional, behavioral, and speech evaluations, among other skill and ability assessments. One other area for assessment that clinicians may consider examining when working on evaluations for individuals with ASD includes the integration of assessments capturing physical and sensory needs. Physical health identifiers that may be included in such evaluations cover physical exercise, sleep, diet and food sensitivities, and elimination. Additionally, sensory evaluations may consider auditory, olfactory, taste, tactile, vestibular, and proprioceptive sensory abilities and needs. This practitioner‐focused chapter includes a brief review of each of the aforementioned physical and sensory abilities and their connection to ASD. Further, implications for practitioners in their assessment of ASD are explored with practical tips and recommendations for providers to use for their future assessments for ASD.
Registration of ‘S15‐10434C’ soybean cultivar with high yield, resistance to multiple diseases, and wide adaptation
Authors: Chen Pengyin , Ali M. L. , Shannon Grover , Crisel Melissa , Smothers Scotty , Clubb Michael , Selves Stewart , Canella Vieira Caio , Lee Dongho , Scaboo Andrew , Usovsky Mariola , Nguyen Henry T. , Mitchum Melissa G. , Li Zenglu , Bond Jason , Meinhardt Clinton , Li Shuxian , Mengistu Alemu , Robbins Robert T. , Mozzoni Leandro A. , Zhang Bo , Smith James R. , Buckley Blair 
Published: April 2022

Abstract‘S15‐10434C’ (Reg. no. CV‐548, PI 699630) is a maturity group V, high‐yielding conventional soybean [Glycine max (L) Merr.] cultivar developed and released in 2019 by the University of Missouri–Fisher Delta Research Center Soybean Breeding Program. S15‐10434C was developed following conventional breeding from a cross between ‘S11‐17025C’ and ‘S11‐14954’, which are Missouri soybean lines. ‘S11‐17025C’ is a high‐yielding cultivar with resistance to multiple diseases, and ‘S11‐14954’ is a line with high yield potential and soybean cyst nematode resistance developed by the University of Missouri soybean breeding program. Before release, S15‐10434C was tested in 107 environments in Missouri and other southern states from 2016 to 2019 for yield and other agronomic traits. On average, S15‐10434C yielded 4,102 kg ha–1, which is higher than the all‐tests mean of 3,907 kg ha–1. S15‐10434C seed contains 40.7% protein and 21.7% oil on a dry‐seed‐weight basis. It exhibits relative maturity of 5.5, determinate growth habit, purple flowers, tawny pubescence, and tan pod wall. Seeds are yellow with intermediate luster and black hila, with seed weight of 13.1 g 100–1 seed. S15‐10434C is 76 cm tall and has resistance to lodging. It is resistant to cyst nematode (races 1, 2, 3, 5, and 14), reniform nematode, peanut and southern root knot nematodes, sudden death syndrome, and frogeye leaf spot and has field tolerance to phytophthora root rot. It is also a chloride excluder. In addition to its high yield potential and desired seed protein content, S15‐10434C has broad adaptation across southern states.
Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins
Authors: Mori Joakin O. , Shafran Jordan S. , Stojanova Marija , Katz Mark H. , Gignac Gretchen A. , Wisco Jonathan J. , Heaphy Christopher M. , Denis Gerald V. 
Published: April 2022

AbstractIn patients with prostate cancer, the duration of remission after treatment with androgen deprivation therapies (ADTs) varies dramatically. Clinical experience has demonstrated difficulties in predicting individual risk for progression due to chemoresistance. Drug combinations that inhibit androgen biosynthesis (e.g., abiraterone acetate) and androgen signaling (e.g., enzalutamide or apalutamide) have proven so effective that new forms of ADT resistance are emerging. In particular, prostate cancers with a neuroendocrine transcriptional signature, which demonstrate greater plasticity, and potentially, increased predisposition to metastasize, are becoming more prevalent. Notably, these subtypes had in fact been relatively rare before the widespread success of novel ADT regimens. Therefore, better understanding of these resistance mechanisms and potential alternative treatments are necessary to improve progression‐free survival for patients treated with ADT. Targeting the bromodomain and extra‐terminal (BET) protein family, specifically BRD4, with newer investigational agents may represent one such option. Several families of chromatin modifiers appear to be involved in ADT resistance and targeting these pathways could also offer novel approaches. However, the limited transcriptional and genomic information on ADT resistance mechanisms, and a serious lack of patient diversity in clinical trials, demand profiling of a much broader clinical and demographic range of patients, before robust conclusions can be drawn and a clear direction established.
Subcutaneous sarcoidosis (Darier–Roussy sarcoidosis) with extensive disease on positron emission tomography: A case report and review of the literature
Authors: Youn Paul , Francis Roslyn J. , Preston Henry , Lake Fiona 
Published: April 2022

AbstractCutaneous manifestations of sarcoidosis are common, but subcutaneous nodules are rare, originally described in 1904 by Darier and Roussy and thought to represent isolated skin disease. We present a 61‐year‐old male who presented with 3 months of subcutaneous nodules on the forearms and knees. Biopsy confirmed sarcoidosis. An [F‐18] fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) showed confluent uptake in the skin of forearms and knees, along with thighs and buttocks, mediastinal, hilar and upper abdominal lymph nodes, and multiple bones. He was well and treated with hydroxychloroquine 400 mg/day. The nodules resolved and a repeat FDG PET/CT at 5 months showed a significant decrease in the uptake at all involved sites. Although a PET scan can demonstrate extensive disease in a patient presenting with subcutaneous nodules, the literature suggests prognosis is good and treatment should start simply with the least toxic approach, such as with hydroxychloroquine therapy.
In Vitro Reconstitution of Kinesin-Based, Axonal mRNA Transport
Authors: Grawenhoff Julia , Baumann Sebastian , Maurer Sebastian P. 
Published: April 2022

AbstractMotor protein-driven transport of mRNAs on microtubules and their local translation underlie important neuronal functions such as development, growth cone steering, and synaptic plasticity. While there is abundant data on how membrane-bound cargoes such as vesicles, endosomes, or mitochondria are coupled to motor proteins, surprisingly little is known on the direct interactions of RNA–protein complexes and kinesins or dynein. Provided the potential building blocks are identified, in vitro reconstitutions coupled to Total Internal Reflection Microscopy (TIRF-M) are a powerful and highly sensitive tool to understand how single molecules dynamically interact to assemble into functional complexes. Here we describe how we assemble TIRF-M imaging chambers suitable for the imaging of single protein–RNA complexes. We give advice on optimal sample preparation procedures and explain how a minimal axonal mRNA transport complex can be assembled in vitro. As these assays work at picomolar-range concentrations of proteins and RNAs, they allow the investigation of molecules that cannot be obtained at high concentrations, such as many large or disordered proteins. This now opens the possibility to study how RNA-binding proteins (RBPs), RNAs, and microtubule-associated proteins act together in real-time at single-molecule sensitivity to create cytoplasmic mRNA distributions.
Live Imaging of RNA Transport and Translation in Xenopus Retinal Axons
Authors: Lin Julie Qiaojin , Cioni Jean-Michel 
Published: April 2022

AbstractIn neurons, specific mRNAs are transported into axons, where their local translation supports essential cellular functions. Over the years, our knowledge of the molecular mechanisms underlying axonal mRNA translation has rapidly expanded. However, tools to study mRNA localization and translation in real time with high spatial precision were not available until recently. Here, we present a live imaging approach to examine axonal mRNA trafficking and translation simultaneously in Xenopus retinal ganglion cells (RGCs), using in vitro synthesized fluorescently labeled mRNAs coupled with a genetically encoded protein tagging system to visualize synthesizing peptides at single-molecule resolution. We further describe the process of image analysis in detail, thus providing a methodology that can be used to investigate new research questions in the field.
Karl Korsch und der Logische Empirismus. Ambivalenzen, Kritik, Perspektiven
Authors: Buckmiller Michael 
Published: April 2022

ZusammenfassungKarl Korschs marxistische Sonderstellung im Verhältnis zum Logischen Empirismus reicht zurück in die freistudentische Bewegung, in der er als aktivistischer Theoretiker durch eine „logische Konstruktionsformel“ die innerorganisatorischen Konflikte überwinden will. Beeinflusst vom englischen Positivismus der Fabian Society bietet er in der deutschen Revolution 1918 eine Konstruktionsformel für die Sozialisierung der Volkswirtschaft. Das Scheitern des erhofften sozialistischen Aufbaus führt zur politischen Radikalisierung und Hinwendung zu einer eigenständigen Marxrezeption, aus deren Gedankenwelt er unter Aufnahme Diltheyscher Elemente das Scheitern des Marxismus der Zweiten Internationale erklärt und die Marxschen Feuerbach-Thesen als dialektisches Bindeglied zwischen Empirismus und revolutionärer Aktion im Sinne der Kommunistischen Internationale aufnimmt. Mit dem Sieg des Stalinismus schließt er den Leninismus in die marxistische Kritik mit ein und nähert sich erneut dem logischen Positivismus des Wiener Kreises (Carnap, Reichenbach). Durch den Nationalsozialismus in die Emigration gezwungen bemüht er sich um eine neue Marx-Interpretation, in der er den methodischen Ansatz der konsequenten historischen Spezifizierung als materialistisch-dialektischen Kern einer aufklärenden sozialwissenschaftlichen Forschung sieht.Die erneute Annäherung an den logischen Positivismus (Unified Science Congress 1939) bleibt am Ende Episode, da aus seiner Sicht weder der Logische Positivismus noch der Marxismus-Leninismus in der realen geschichtlichen Welt tatsächlich weiterführende emanzipatorische Problemlösungen der zentralen Fragen der Menschheit liefern konnten.
Einleitung zu Hans Reichenbach, „Die freistudentische Idee. Ihr Inhalt als Einheit [Auszug]“
Authors: Damböck Christian , Werner Meike G. 
Published: April 2022

ZusammenfassungDer hier in einem Auszug edierte Text von Hans Reichenbach hat schon vor über vier Jahrzehnten einige Aufmerksamkeit erfahren, als er 1974 von Ulrich Linse ausführlich diskutiert und vier Jahre später von Maria Reichenbach in Übersetzung in Reichenbachs Selected Writings 1909–1953 aufgenommen wurde. Ein Jahr davor hatte sich Andreas Kamlah im Anhang seiner deutschsprachigen Edition von Reichenbachs The Rise of Scientific Philosophy (1951) auf diesen Text bezogen. Sein ursprünglicher Erscheinungsort war ein drei Aufsätze umfassender Band, den Reichenbach gemeinsam mit den Autoren der anderen beiden Beiträge, Hermann Kranold (1888–1942) und Carl Landauer (1891–1983), ediert und als Vorbereitung des 13. Freistudententages im Mai 1913 publiziert hat. Der spätere Wirtschaftswissenschaftler Carl Landauer war seit 1912 Mitglied der SPD. Kranold, der Medizin und Nationalökonomie studierte, trat ebenfalls 1912 in die SPD ein und arbeitete 1919 unter anderem mit Otto Neurath die Sozialisierungsprogramme für Sachsen und Bayern aus.
Einleitung zu Rudolf Carnap, „Deutschlands Niederlage: Sinnloses Schicksal oder Schuld?“ (1918)
Authors: Damböck Christian 
Published: April 2022

ZusammenfassungDer hier edierte Text „Deutschlands Niederlage: Sinnloses Schicksal oder Schuld?“ ist ein unveröffentlicht gebliebenes Manuskript aus dem Nachlass von Rudolf Carnap. Der Text war von Carnap unter dem Pseudonym Kernberger (nach Carnaps Wohnort in Jena) verfasst worden. Er war zur Veröffentlichung in den Politischen Rundbriefen vorgesehen, einer vom späteren DDR-Historiker Karl Bittel edierten Zeitschrift. Diese Zeitschrift war schon vor dem Kriegsende „vertraulich, als Handschrift“ (Bittel, 1918) erschienen. Zwischen Oktober 1918 und Ende 1919 fungierte sie dann als öffentliches politisches Organ der sozialdemokratisch orientierten Freideutschen. In Bittels Editorial zur ersten, mit 5. Oktober 1918 datierten, öffentlichen Nummer heißt es:Die hier proklamierte Unabhängigkeit bedeutet nicht zwangsläufig politische Neutralität, stammten die Autoren des Blattes doch in der Mehrzahl aus einem der USPD (Unabhängige Sozialdemokratische Partei Deutschlands) nahe stehenden Kreis von (Berliner) Freideutschen. Dieser Kreis publizierte Anfang 1919 einen von Helmut Tormin verfassten und von Carnap mit unterzeichneten „Aufruf an die freideutsche Jugend“, in dem die Grundsätze einer „[d]emokratisch-sozialistischen Gruppe der Freideutschen Groß-Berlins“ (Tormin, 1968, S. 615) charakterisiert wurden.
Exploring the Human Impact of Public Health Interventions in T.C. Boyle’s “The Fugitive”
Authors: Childress Andrew , Nuila Ricardo 
Published: April 2022

AbstractIn T.C. Boyle’s (Boyle, The Relive Box and Other Stories. HarperCollins, New York, 2017) short story, “The Fugitive,” the public health practitioners treating the protagonist, Marciano, for tuberculosis (TB) override his right to decide his own treatment plan. Marciano’s struggles show an inherent conflict in public health ethics between protecting the community from infectious diseases and respecting a person’s right to autonomous decision making. Public health officials in the story failed to treat him as a human being by not eliciting his illness narrative. To avoid these failures in the future, we recommend that public health officials adopt a narrative-based approach to policymaking and training public health practitioners. Doing so will help public health officials build trust in healthcare institutions, thereby increasing compliance with public health measures. In this chapter we will explore Boyle’s story as a way to frame concerns about the effectiveness, utility, proportionality, and necessity of the public health measures taken in this case.
Why Stories Matter: An Introduction to Narrative Approaches to Public Health Ethics
Authors: Larson Stephanie A. 
Published: April 2022

AbstractThis chapter provides a brief overview of narrative public health ethics to help guide engagement with the narratives contained within this book. The first section introduces narrative medical ethics, which serves as the foundation for the public health narrative ethics we propose in this book. The second section explores the developing field of narrative public health ethics and surveys scholars who have laid the groundwork for this approach. Finally, conclusions are drawn with consideration given to major challenges and future directions for the field of narrative public health ethics.
Particle Morphology Effect on the Soil Pore Structure
Authors: Ali Maroof M. , Eidgahee Danial Rezazadeh , Mahboubi Ahmad 
Published: April 2022

AbstractThe soil fabric can be expressed as a network model. Granular media voids connectivity and constriction size distribution may lead to movement of air, fluids, and solids in the soil, and therefore affect the chemical, physical and mechanical properties of soils. Understanding the soil voids areas and their interconnection might be helpful in understanding different phenomena such as transport in porous media, water retention, fluid flow in the soil, soil contamination, internal erosion, suffusion, and filtration. In addition, specifying the soil voids interconnectivity can help researchers and practical engineers to provide the best rehabilitation and remediation approaches. The pore network was investigated in the current study, assuming the soil particles to be similar to discrete spheres and particles with different shapes. Also, based on the modelling techniques, the profiles of pore connectivity and constriction size distribution were assessed.
Research on the Influence of Transverse Limit of Support on Construction Monitoring of Special-Shaped Bridge
Authors: Chao Yi , Jun Dong 
Published: April 2022

AbstractIn order to understand whether the alignment, internal force and cable force of the special-shaped cable-stayed bridge can still meet the design and code requirements due to the influence of the transverse displacement of the support during the construction process, the transverse displacement of the girder arch system is restricted before the removal of the support. The difference between the measured value and the designed value at each stage of the boom is within ±5%, which meets the design and specification requirements. In this paper, the pedestrian bridge in Anyi County, Nanchang City, Jiangxi Province is taken as an example. MADIS/Civil software is used for finite element simulation analysis in the construction stage, and the linear shape, internal force and cable force of the superstructure are monitored. The results show that the measured deformation values of arch ribs and beams meet the design and specification requirements during the whole construction process. The difference between the measured value and the designed value at each stage of the boom is within ±5%, which meets the design and specification requirements.
Probabilistic Analysis of a Braced Excavation Considering Soil Spatial Variability
Authors: Ding Shirui , Yang Haoqing , Xu Jiabao 
Published: April 2022

AbstractDeep braced excavations are generally known to be associated with risks from various sources. The inherent uncertainty of soil strength properties is one of the primary factors that influence the deformation of the retaining wall and the ground settlement. In this study, the numerical model of a braced excavation is firstly established by an elastic-plastic model with Drucker-Prager failure criterion in COMSOL Multiphysics. Random field theory is used to simulate the spatial variability of Young’s modulus. The uncertainty of braced excavation on ground settlement and deflection of retaining wall by stages are studied by Monte Carlo simulation based on 500 random fields. The struts can lessen the uncertainty of wall deflection during excavation but have a limited impact on settlement. The deterministic result may underestimate the settlement of braced excavation. The uncertainty of wall deflection is significantly reduced after the first strut. The uncertainty of wall deflection above the depth of struts is well-controlled at the final stage of excavation.
Influence of Excavation of Horizontal Adit Tunnel on Main Tunnel and Safety Analysis
Authors: Fu Liang 
Published: April 2022

AbstractFor the influence of horizontal adit tunnel on the main tunnel, taking a tunnel as an example, MIDAS finite element software is used to analyzes the displacement and stress state of the primary support and secondary lining structure of the main tunnel before and after excavation, gives the local structural safety factor at the junction of the two, and analyzes the safety of the lining structure. The results show that: (1) After the main tunnel lining is removed, the lining has a certain displacement to the free face, the maximum is 55.3 mm, and the displacement changes little after the lining of the horizontal adit tunnel; (2) The safety factor calculation of the main tunnel lining at the junction, except the inverted arch area of primary support, all other parts meet the specification requirements.
Parameter Sensitivity Analysis of Long Span PC Continuous Beam Bridge with Corrugated Steel Webs
Authors: Jiang Yu , Long Peiheng 
Published: April 2022

AbstractIn order to explore the regularity of alignment and stress variation of long-span corrugated steel web (CSW) continuous beam bridge during cantilever casting construction was taken as the engineering background. Based on numerical simulation, the sensitivity of parameters of alignment and stress of the main beam is carried out on cast-in-place section weight, modulus of elasticity and temperature gradient. The results show that the obvious influence of cast-in-situ section weight and temperature gradient on the alignment and stress is the key control parameters, while modulus of elasticity is the secondary control parameters. Therefore, it is necessary to monitor concrete dense and environmental temperature change in real time during construction, closure at a suitable temperature. Correct construction errors in time, ensure structural safety and smooth alignment.
An Algorithm to Obtain Moment-Curvature Diagram for Reinforced Concrete Sections
Authors: Mohemmi Morteza 
Published: April 2022

AbstractReinforced concrete is one of the most common materials in construction and knowledge of the behavior of reinforced concrete with lateral reinforcement has been one of the important topics in researches. Due to the high cost of laboratory studies, researchers have tried to develop numerical methods with the help of relationships obtained from analytical researches as well as various programs including finite element codes. In most studies, moment-curvature diagrams in reinforced concrete with confined cores have been significant in studying the behavior and performance of reinforced concrete sections. In this research, using analytical relations and applying MATLAB program, a suitable algorithm for calculating the moment-curvature in reinforced concrete columns with lateral reinforcement is presented. In this algorithm, the famous Mander and Kent and Park models are used and a method for eliminating the non-confined concrete cover during the analysis is proposed. Finally, the moment-curvature was obtained for 4 sections of reinforced concrete and compared with the KSU-RC program, which show a good agreement.
Reliability Analysis of Gravity Retaining Wall
Authors: Zhang Baohua , Zhang Zhenkang , Zheng Peng 
Published: April 2022

AbstractIn this article, When considering effect of earthquake and under ground water. The failure mode of gravity earth-retaining wall and the way of settling the limit of reliability are analyzed. Based on project improved JC Method is applied to calculate unitary reliability, the pertinence with the invalid mode being considered farther, the limit of reliability is calculated.