bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant changes of dynamic global synchronization in patients with Parkinson's disease
Authors: Wang Yong , Sun Zhongru , Zhou Zhijun 
Published: April 2022

Background Patients with Parkinson's disease (PD) have been documented with disrupted dynamic profiles of functional connectivity. However, the complementary information that is relevant to the dynamic pattern of global synchronization in patients with PD requires further investigation. Purpose To reveal the aberrant dynamic profiles of global synchronization involved in PD with a focus on temporal variability, strength, and property. Material and Methods A total of 46 patients with PD and 50 matched healthy controls (HCs) were enrolled. Degree centrality (DC) was used as the metric of global synchronization. The intergroup differences in the dynamic DC (dDC) pattern were compared, followed by further analysis of their clinical relevance in PD. Results Relative to HCs, the PD group showed decreased dDC variability in right inferior occipital gyrus, right insula, right middle occipital gyrus (MOG), and bilateral postcentral gyrus. The dDC variability in the MOG was significantly correlated with MoCA score. Two states (state I and state II) were suggested. Relative to HCs, the PD group demonstrated a shorter mean dwell time (MDT) in state I, a longer MDT in state II, and fewer transitions. For the PD group, dDC properties were significantly correlated with UPDRS-III scores. In state II, significantly decreased dynamic dDC strength in bilateral supplementary motor area was observed in the PD group, with a significant correlation with UPDRS-III scores. Conclusion These findings on PD imply that dynamic alterations of global synchronization are engaged in the dysfunction of movement and cognition, deepening the understanding of deteriorations that underlie PD with complementary evidence.
An Umbrella Review of Systematic Reviews With or Without Meta-Analysis Assessing Treatment Outcomes and Efficiency of Self-Ligating Brackets
Authors: Mukhopadhyay Meghna , Verma Shubhnita , Chitra Prasad 
Published: April 2022

Introduction Self-ligating bracket systems are popular and seem to demonstrate lesser friction, allowing tooth movement without exerting unwanted forces on surrounding structures. This umbrella review aimed to compare self-ligating and conventional bracket systems for treatment efficiency. Methods An electronic search in 8 databases was performed for literature published between January 1, 1990, and October 1, 2021, with manual hand-searching of references of retrieved articles. Quality assessment was performed using the risk of bias in a systematic tool by 2 independent reviewers. Data were extracted using a prepiloted form (Joanna Briggs Institute) for evidence synthesis. Corrected covered area was calculated to quantify study overlaps across systematic reviews with or without meta-analysis. Results 605 articles were retrieved, of which 16 were selected. Most included studies had a low risk of bias, except for 6 that showed an unclear risk of bias. Data analysis revealed a reduction in lower incisor proclination, bacterial accumulation, and oral malodor using self-ligating appliances. Conclusions Self-ligating systems reduce mandibular incisor proclination, bacterial accumulation, external apical root resorption, chairside time, and oral malodor. No other differences could be demonstrated in comparison with conventional appliance systems.
Acute Anterior Cruciate Ligament Rupture: Repair or Reconstruction? Five-Year Results of a Randomized Controlled Clinical Trial
Authors: Hoogeslag Roy A.G. , Huis In ’t Veld Rianne , Brouwer Reinoud W. , de Graaff Feike , Verdonschot Nico 
Published: April 2022

Background: High-level evidence for short–term outcomes of contemporary anterior cruciate ligament (ACL) suture repair (ACLSR) in comparison with those of ACL reconstruction (ACLR) is scarce. High-level evidence for mid- and long–term results is lacking, whereas outcomes of ACLSR in several historical studies were shown to deteriorate at midterm follow–up after initial good short–term outcomes. Hypothesis: Contemporary ACLSR is noninferior to ACLR in the treatment of acute ACL rupture in terms of patient self–reported outcomes at 5 years postoperatively. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 48 patients were enrolled in the study and, after stratification and randomization, underwent either dynamic augmented (DA) ACLSR or anatomic single–bundle ACLR. The primary outcome measure was the International Knee Documentation Committee 2000 (IKDC) subjective score (IKDCs). Furthermore, the Knee injury and Osteoarthritis Outcome Score (KOOS), Tegner Activity Scale score (TAS), visual analog scale score for satisfaction (VASs), IKDC physical examination score (IKDCpe), limb symmetry index for quadriceps (LSIq) and hamstrings (LSIh) strength and jump test battery (LSIj), Kellgren-Lawrence grade of osteoarthritis (OA), and rate of adverse events were recorded. Analyses were based on an intention–to–treat principle. Results: The lower limit of the 2–sided 95% CI for the median IKDCs of the DA ACLSR group (n = 23; 75.9) was lower than the prespecified noninferiority margin (n = 21; 86.6). Therefore, the null hypothesis was rejected. However, the upper limit of the 2–sided 95% CI of the DA ACLSR group (100.0) was higher than the median IKDCs of the ACLR group (96.6), rendering the result for noninferiority inconclusive. No statistical difference was found between groups for median IKDCs (repair, 90.2; reconstruction, 96.6). Furthermore, no statistically significant differences were found for any of the secondary outcome measures for the DA ACLSR compared with the ACLR group: KOOS Symptoms, 92.9 versus 96.4; KOOS Pain, 100 versus 97.2; KOOS Activities of Daily Living, 100 versus 100; KOOS Sport and Recreation, 85.0 versus 100; TAS score, 7.0 versus 6.5; VASs, 9.2 versus 8.7; IKDCpe, 81.8% versus 100%; LSIq, ≥91.6 versus ≥88.2; LSIh, ≥95.1 versus ≥90.7; LSIj, ≥94.2 versus ≥97.6; OA grade 0, 90.9% versus 77.8%; clinical ACL failure rate, 20.8% versus 27.2%; and repeat surgery rate, 37.5% versus 20.0%, respectively. Conclusion: It remains inconclusive whether the effectiveness of DA ACLSR is noninferior to that of ACLR in terms of subjective patient–reported outcomes as measured using the IKDCs. Although DA ACLSR may be a viable treatment option for patients with acute ACL rupture, caution must be exercised when considering this treatment for young, active patients, corresponding to the present study population.
The in vitro effects of vitamin 1, 25(OH) 2 D3 on expression of cytokines: In new-onset systemic lupus erythematosus patients
Authors: Chegni Hamid , Heidarvand Mohammad 
Published: April 2022

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting a variety of factors in the immune system. Awareness of the role of cytokines in SLE has led to new clinical perspectives in its pathogenesis; therefore, the aim of this study was to investigate the effect of vitamin 1, 25(OH) 2 D3 (D3) on the expression of IL-2, IL-4, IL-5, IL-10, and IFN-γ cytokines in patients with lupus. Methods: A total of 65 new-onset SLE patients were enrolled in the study. After peripheral blood mononuclear cell isolation, the lymphocytes of each patient were divided into two groups, one treated with a concentration of 50 μmol vitamin D3 (test) and the other untreated with vitamin D3 (control), were cultured. After 24 hours, the cultured cells were collected and the expressions of IL-2, IL-4, IL-5, IL-10, and IFN-γ genes were analyzed by RT-qPCR. Results: It was observed that vitamin D3 reduced expression of IFN-γ, IL-4, IL-5, and IL-10 genes by 73, 50, 37, and 29%, respectively, and increased IL-2 gene expression by 31% ( p ≤ 0.05). Conclusion: With different patterns of cytokine changes in patients with lupus in different studies, it seems that the pattern of cytokine changes is largely dependent on the phase of the disease and with this study it can be concluded that vitamin D3 administration at the time of diagnosis and in the early stages and before starting treatment have different effects from its administration in the acute stage of the disease, which requires further studies to prove. It seems that in patients with systemic lupus erythematosus, vitamin D should be administered taking into account the phase of the disease.
An Empirical Study on the Corporate Social Responsibility Regime in India: Pre-COVID and COVID Times
Authors: Garg Varun , Agarwal Sakshi 
Published: April 2022

Companies have shown social responsibility towards their stakeholders through corporate philanthropic efforts, known as Corporate Social Responsibility (‘CSR’). These efforts aim to maximise the welfare of the stakeholders and take care of the needs of society. The parent legislation for the Indian companies, that is, the Companies Act, brought a paradigm shift in 2013 when it mandated certain companies to spend mandatorily on CSR activities. Since then, the CSR legislation has been subject to frequent changes through amendments and clarifications. Various changes were brought to CSR policies in the past 2 years during COVID-19, including allocation of CSR funds towards COVID-19 relief funds, carry forward of excessive CSR expenditure and 100% tax deduction on COVID-19-related activities. This has affected how companies allocate their CSR funds. To study this change, this empirical study analyses the shifts in CSR expenditure of the top 25 companies of the Fortune 500 list in pre-COVID-19 financial year 2017–2018 and COVID-19 hit financial year 2020–2021. The study uses a secondary data collection method, that is, self-reported annual reports, to arrive at ratios given as percentages or fractions, and a comparison is made across the two periods. The authors deliberate upon the limitations of the CSR regime as revealed by the COVID-19 pandemic and address questions relating to the CSR regime’s efficiency in providing societal good. Furthermore, the authors study the modified CSR expenditure pattern adopted by several companies consequent of COVID-19. This study concludes by offering recommendations that strive to inspire a more sustainable, efficient and pragmatic CSR regime in India. JEL Classification: G39, D22, M14
A Retrospective, Descriptive Study of Dyspnea Management in a Multidisciplinary Interstitial Lung Disease Clinic
Authors: van den Bosch Laura , Wang Ting , Bakal Jeffrey A. , Richman-Eisenstat Janice , Kalluri Meena 
Published: April 2022

Background: Fibrotic interstitial lung diseases (F-ILDs) have a high symptom burden with progressive dyspnea as a primary feature. Breathlessness is underrecognized and undertreated primarily due to lack of consensus on how to best measure and manage it. Several nonpharmacologic and pharmacologic strategies are published in the literature, however there is a paucity of real-world data describing their systematic implementation. Objectives: We describe the types of breathlessness interventions and timing of implementation in our multidisciplinary collaborative care (MDC) ILD clinic and the impact of our approach on dyspnea trajectory and acute care use in ILD. Methods: A retrospective, observational study of deceased ILD patients seen in our clinic (2012-2018) was conducted. Patients were grouped by baseline medical research council (MRC) grade and dyspnea interventions from clinic enrolment until death were examined. Healthcare usage in the last 6 months of life was collected through Alberta’s administrative database. Results: Eighty-one deceased ILD patients were identified. Self management advice was provided to 100% of patients. Pulmonary rehabilitation (PR) and home care (HC) referrals were made in 40% and 57% of patients, respectively. Eighty percent were treated with oxygen and 53% with opioids during the study. MDC-initiated referral to PR and HC, oxygen and opioid prescriptions were provided a median of 13, 9, 11, and 4 months prior to death, respectively. Stepwise implementation of interventions was observed more commonly in MRC 1-2 and concurrent implementation in MRC 4-5. Conclusions: Our clinic’s approach allows early and systematic dyspnea management.
Evaluation of Ceftazidime Use in the Neonatal Intensive Care Unit and Association With Cephalosporin-Resistant Gram-Negative Bacteria
Authors: Mayes Rebecca A. , Johnson Peter N. , White Bryan P. , Neely Stephen B. , Chaaban Hala , Miller Jamie L. 
Published: April 2022

Background Cefotaxime shortage in 2015 led to increased ceftazidime use in the neonatal intensive care unit (NICU). Objective The purpose was to explore whether ceftazidime increases risk for development of resistant gram-negative organisms. Methods Retrospective evaluation of NICU patients with cultures positive for Escherichia coli, Pseudomonas aeruginosa, Klebsiella species, or Stenotrophomonas maltophilia between January1, 2015 and August 31, 2020. Isolates were excluded if obtained from same patient and source within 90 days or if patient ≤7 days of life or admitted from a referring hospital. Data collection included demographics and clinical parameters, and culture/susceptibility data. The primary objective was comparison of pathogens and clinical parameters in those with and without third-generation cephalosporin resistance. The secondary objectives included a comparison between those with and without ceftazidime exposure and identification of factors associated with resistance. Comparisons were made using χ2, Fisher exact tests, or Wilcoxon tests. A logistic regression was used to identify risk factors for resistance. Results Overall, 349 isolates, representing 215 patients, were included. The most common source was endotracheal (n = 192, 55.0%) and pathogens were E coli (31.8%) and P aeruginosa (29.2%). Overall, 12.3% (n = 43) were resistant and these were obtained after longer parenteral nutrition (PN), central line access, and antibiotic days versus susceptible isolates. Higher resistance was noted after ceftazidime exposure versus no exposure, 19.1% versus 6.6%. Each day of ceftazidime was associated with 13% greater odds of P aeruginosa resistance (adjusted odds ratio: 1.13 [95% confidence interval: 1.03-1.23]). Conclusion and Relevance Ceftazidime duration was associated with increased risk for P aeruginosa resistance. Additional studies are needed to confirm these findings.
Changing trends in pseudoretinoblastoma diagnoses: A 10 year review from the United Kingdom
Authors: Badhwar Vinay , Yeo Damien CM , Joshi Samruddhi , Clifton Charlotte , Fraser Maxine , Naeem Zishan , Sagoo Mandeep S. , Reddy M. Ashwin 
Published: April 2022

Aim To study the different types and frequency of pseudoretinoblastoma (pseudoRB) lesions who present to a retinoblastoma centre due to concern that the condition may be retinoblastoma. Methods A retrospective chart review of 341 patients presenting sporadically to the Royal London Hospital from January 2009 to December 2018. Results 220 patients (65%) were confirmed to have retinoblastoma, while 121 (35%) had pseudoRB. There were 23 differential diagnoses in total. The top 3 differential diagnoses were Coats’ disease (34%), Persistent Foetal Vasculature (PFV) (17%) and Combined Hamartoma of Retina and Retinal Pigment Epithelium (CHR-RPE) (13%). PseudoRBs differed with age at presentation. Under the age of 1 (n = 42), the most likely pseudoRB conditions were PFV (36%), Coats’ disease (17%) and CHR-RPE (12%). These conditions were also the most common simulating conditions between the ages of 1 and 2 (n = 21), but Coats’ disease was the most common in this age group (52%), followed by CHR-RPE (19%) and PFV (14%). Between the ages of 2 and 5 (n = 32), Coats’ disease remained the most common (44%) pseudoRB lesion followed by CHR-RPE (13%), or PFV, Retinal Astrocytic Hamartoma (RAH), familial exudative vitreoretinopathy (FEVR) (all 6.3%). Over the age of 5 (n = 26), pseudoRBs were most likely to be Coats’ disease (35%), RAH (12%), Uveitis, CHR-RPE, FEVR (all 7.7%). Conclusion 35% of suspected retinoblastoma cases are pseudoRB conditions. Overall, Coats’ disease is the most common pseudoRB condition, followed by PFV. Hamartomas (CHR-RPE & RAH) are more prevalent in this cohort, reflecting improvements in diagnostic accuracy from referring ophthalmologists.
Treatment of chronic diabetic macular oedema with intravitreal fluocinolone acetonide implant; real-life analysis of outcomes during overall treatment period
Authors: Cox Laurence , Li Yanda , Fotuhi Majid , Vermeirsch Sandra , Yeung Ian , Hamilton Robin D , Rajendram Ranjan , Lukic Marko 
Published: April 2022

Purpose To assess the clinical efficacy of the fluocinolone acetonide (FA) intravitreal implant ( Iluvien, Alimera Sciences) over a 12-month period in a population resistant to treatment with first-line anti-VEGF agents. Methods This study is a retrospective cohort study assessing functional and anatomical outcomes in 13 eyes of 12 patients treated for diabetic macular oedema (DMO) with a single fluocinolone implant (FA) ( Iluvien) under real-world conditions. The follow-up period includes the time of first intravitreal treatment (incl anti-VEGF or short-lasting steroids) given until 12 months post FA implant insertion. Primary outcomes were best corrected visual acuity (BCVA), measured using the modified Early Treatment Diabetic Retinopathy Study (ETDRS) grading scale, and central foveal thickness (CFT), measured using Topcon 3DOCT-2000 (Topcon Inc) SD-OCT imaging. Mean BCVA and CFT were measured before anti-VEGF treatment, after anti-VEGF treatment, at the time of Iluvien implant insertion, and 6 and 12 months after Iluvien implant insertion. The t-paired sample test was used to ascertain statistical significance of changes in comparison of two samples while the ANOVA analysis was used in comparison of three or more samples. Results The baseline BCVA (SD) of the cohort prior to initiation of anti-VEGF treatment was 47.45 (12.27) ETDRS letters whilst the mean CFT (SD) was 579 (203) microns. Following completion of anti-VEGF therapy, the mean improvement in vision was 8.9 ETDRS letters (p = 0.1) whilst the mean reduction in CFT was 197 microns (p = 0.028). Mean BCVA (SD) at the time of insertion of the FA implant was 55.15 (11.16) ETDRS letters and mean (SD) CFT at time of insertion of the FA was 454.62 μm (109.51). Following the 12-month treatment period with the FA implant, BCVA (SD) was 62.15 (10.25) ETDRS letters (p = 0.0331) and the mean (SD) CFT was 404.36 μm (142.92), a change of −50.26 μm from baseline (p = 0.0369). Conclusions This study has shown that statistically significant improvements in BCVA and CFT can be achieved over a 12-month period with the Iluvien implant. The implant has been shown to be a safe option in the treatment of DMO and may have a role to play in achieving good functional and anatomical outcomes in DMO while also reducing the frequency of follow-up appointments required to maintain stable vision in the working-age population.
Spontaneous suprachoroidal haemorrhage in haemophilia coincident with ChAdOx1 nCoV-19 vaccine
Authors: Behera Geeta , Jossy Ajax , Deb Amit Kumar , Neelakandan Siddharth , Basavarajegowda Abhishek 
Published: April 2022

Purpose To report a case of spontaneous suprachoroidal haemorrhage in a haemophilia patient immediately following ChAdOx1 nCoV-19 vaccination. Case presentation A 60-year-old man with haemophilia developed painful vision loss in his left eye a day following the ChAdOx1 nCoV-19 vaccination due to acute angle-closure glaucoma from a massive suprachoroidal haemorrhage. He had an extremely deranged coagulation profile; activated partial thromboplastin time (APTT): 89 s, normal range 29–35 s After factor VIII transfusion, ocular hypotensive therapy and systemic/topical steroids, the suprachoroidal haemorrhage and glaucoma resolved, but the vision remained poor. Conclusion Spontaneous suprachoroidal haemorrhage may be seen in haemophiliacs with deranged coagulation profiles. In our case, it followed ChAdOx1 nCoV-19 vaccination, and we recommend caution and checking the coagulation profile in such patients apriori.
Task effects and the yes-bias in heritage language bilingualism
Authors: Romano Francesco 
Published: April 2022

Aims and objectives/purpose/research questions: This study investigated three key issues in heritage language research. Previous research shows heritage language speakers have an advantage on tasks of oral production compared to L2 speakers who instead perform better on written tasks requiring use of metalinguistic skills. Furthermore, both L2 and heritage speakers are claimed to have a yes-bias towards retaining ungrammaticality in grammaticality judgement tests (GJTs). Finally, the morphological domain has been shown to be as problematic for heritage language speakers as L2 speakers, but research in lesser-known languages is needed. Design/methodology/approach: Adult L1, L2, and heritage language speakers of Italian were compared on an oral priming task and timed GJT. Both accuracy and response times were elicited from the latter test. The forms investigated were object and si-passive pronouns which lack corresponding forms in Swedish, the dominant language of the bilingual groups. Data and analysis: Mixed-effects regression was modelled to accuracy on the priming and GJT and response time data from the GJT. In contrast, a d-prime analysis was used to measure the degree of sensitivity to grammaticality and bias towards correct and incorrect answers in the GJT. Findings/conclusions: Overall, the two bilingual groups performed quite similarly across the measures tested. All three groups show high sensitivity to grammaticality and a very similar bias for yes-answers on both grammatical and ungrammatical items. Originality: The study is the first to employ a d-prime analysis to explore in greater detail the differences in knowledge of grammaticality between heritage, L2, and monolingual populations. It also presents a brief review of the limited existing research in heritage Italian. Significance/implications: Any advantages by task for either bilingual group level out by the time high proficiency levels are reached but may be associated with literacy levels when metalinguistic skills are measured. The yes-bias is likely a characteristic intrinsic to GJTs rather than a peculiarity of bilingual speaker knowledge. Morphology is problematic also for heritage speakers of lesser-known languages.