bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mixed-method study exploring experiences, perceptions, and acceptability of using a Safe Delivery mHealth Application in two district hospitals in Rwanda
Authors: Nishimwe Aurore , Conco Daphney Nozizwe , Nyssen Marc , Ibisomi Latifat 
Published: January 2022

Abstract
Background: Innovative use of mobile health (mHealth) technology in timely management of childbirth complications is a promising strategy, but its evidence base is limited. The Safe Delivery mHealth Application (SDA) is one of the recent mhealth applications (loaded in smartphones) which is a clinical decision support and training tool for basic emergency obstetric and newborn care (BEmONC). This paper describes, the health providers’ experiences, perceptions, and acceptability of using the SDA, as well as the perceptions of key stakeholders. Methods: A mixed-methods approach was utilized. Quantitative methods consisted of a self-reported acceptability survey, administered to 54 nurses and midwives, including questions on their usage and perceptions of the SDA. Descriptive statistics were employed to analyze the survey data. Qualitative methods included two focus group discussions with 24 nurses and midwives, and six key informant interviews with stakeholders (maternity matrons, responsible for maternal and child health, and district hospital managers). Thematic analysis was performed and selected quotations used to illustrate themes. The study took place in two district hospitals in Rwanda.Results: Quantitative results found that 31 (57.4%) participants used the SDA four to six times per week. Many participants felt more confident (53.7%) and better at their job (40.7%) since having the SDA. Likert scale survey responses (1-5, 1 =Strongly Disagree, 5 =Strongly Agree) indicated general agreement that SDA is easy to use (Mean =4.46), is an effective decision support tool (4.63), and training tool (4.65). Qualitative results included themes on perceived usefulness; professional growth acquired through the use of the SDA; SDA, an empowering, intuitive, and user-friendly technology; desired SDA features and functions; benefits of SDA as perceived by key informants, and future use of the SDA. Conclusion: The nurses and midwives perceive the SDA as having improved their ability to manage childbirth complications. Key stakeholders also perceive the SDA as a useful tool with a reasonable cost and recommend its implementation in routine practices. This study deepens the understanding of the potential benefits of mHealth such as the SDA in low-income settings, like Rwanda. It also provides more evidence on the impact of mHealth in assuring quality BEmONC.
The Effect of Educational Intervention on Health Literacy, Self-efficacy and Quality of Life in Suburban Women of Mashhad
Authors: Khandehroo Mansooreh , Peyman Nooshin , aval Mahdi gholian , Tehrani Hadi 
Published: January 2022

Abstract
BackgroundHealth literacy is one of the important factors to improve menopausal quality of life that Proper and timely education and tailored to the needs of individuals, caused to improve quality of life. This study aimed to investigate the effect of educational intervention on health literacy, self-efficacy, and quality of life in women.MethodThis quasi-experimental study with the control group was performed on 107 suburban women aged 40-60 years during 2021-2022. Participants were randomly selected by substituting and selected avenue number 3 as the experimental group and 6 as the control group. instruments of this study were Iranian Health Literacy and Scherer Self-Efficacy and Menopausal Quality of Life Questionnaires. The educational intervention was performed in 4 training sessions of 95 minutes once a week.Questionnaires were completed before training, immediately after training, and 3 months later. Data were analyzed by SPSS21 and independent t-test, Kruscalovalis, and linear regression tests.ResultsThe mean score of health literacy in the experimental group before intervention (9 ± 11.36) and immediately after the intervention (20.65 ± 11.41) and three months after the intervention (21.09 ± 11.78) was the mean score of self-efficacy in the experimental group before the intervention (13.72 ± 44.73) and immediately after the intervention (54.76 ± 14.36) and three months after the intervention (55.96 ±14.80). The mean quality of life score of the experimental group was (27.33 ± 80), immediately after the intervention (62.66 ± 22.45) and 3 months after the intervention (51.12 ± 23.57).ConclusionThis study obtain that educational interventions improve quality of life, health literacy, and self-efficacy. The mean score of quality of life, health literacy, and self-efficacy increased, immediately after training and 3 months later in the experimental group. The difference between the experimental and control groups was significant. There was a positive relationship between quality of life and education, job, and income. This relationship was also positive and significant in self-efficacy and health literacy. Three months after the intervention, there was a significant relationship between health literacy and quality of life.
Circular stapling anastomosis with indocyanine green fluorescence imaging for cervical esophagogastric anastomosis after thoracoscopic esophagectomy: A propensity score-matched analysis
Authors: Shishido Yuji , Matsunaga Tomoyuki , Makinoya Masahiro , Miyauchi Wataru , Shimizu Shota , Miyatani Kozo , Uejima Chihiro , Morimoto Masaki , Murakami Yuki , Hanaki Takehiko , Kihara Kyoichi , Yamamoto Manabu , Tokuyasu Naruo , Takano Shuichi , Sakamoto Teruhisa , Saito Hiroaki , Hasegawa Toshimichi , Fujiwara Yoshiyuki 
Published: January 2022

Abstract
Background: Thoracoscopic esophagectomy has been widely used worldwide as a curative surgery for esophageal cancer, but complications, such as anastomotic leakage and stenosis remain a major concern. Therefore, this study aimed to evaluate the efficacy of circular stapling anastomosis with indocyanine green (ICG) fluorescence imaging, which was standardized for cervical esophagogastric anastomosis after thoracoscopic esophagectomy.Methods: In total, 121 patients with esophageal cancer who underwent thoracoscopic esophagectomy with radical lymph node dissection and cervical esophagogastric anastomosis between November 2009 and December 2020 at Tottori University Hospital were enrolled in this study. Patients who underwent surgery before the anastomotic method was standardized were included in the classical group (n = 82), and patients who underwent surgery after standardization were included in the ICG circular group (n = 39). We compared the short-term postoperative outcomes, including anastomotic complications, between the two groups using propensity matched analysis, and evaluated the risk factors for anastomotic leakage using logistic regression analyses.Results: Of 121 patients, 33 were respectively included in each group after propensity score matching. The clinicopathological characteristics of patients between the two groups did not differ after matching. In perioperative outcomes, a significantly higher proportion of patients who underwent surgery using the laparoscopic approach (P < 0.001) and narrow gastric tube (P = 0.003), as well as those who had a lower volume of blood loss (P = 0.009) in the ICG circular group were seen after matching. Moreover, the ICG circular group had a significantly lower incidence of anastomotic leakage (39% vs. 9%, P = 0.004) and anastomotic stenosis (46% vs. 21%, P = 0.037) and a shorter postoperative hospital stay (30 vs. 20 days, P < 0.001) than the classical group. In the multivariate analysis, anastomotic method was an independent risk factor for anastomotic leakage after thoracoscopic esophagectomy (P = 0.013).Conclusions: Circular stapling anastomosis with ICG fluorescence imaging is effective in reducing complications including anastomotic leakage and stenosis.
Phylogenies From Unaligned Whole Genomes Using Sequence Environments of Amino Acid Residues
Authors: Aledo Juan Carlos 
Published: January 2022

Abstract
Alignment-free methods for sequence comparison and phylogeny inference have attracted a great deal of attention in recent years. Several algorithms have been implemented in diverse software packages. Despite the great number of existing methods, most of them are based on word statistics. Although they propose different filtering and weighting strategies and explore different metrics, their performance may be limited by the phylogenetic signal preserved in these words. Herein, we present a different approach based on the species-specific amino acid neighborhood preferences. These differential preferences can be assessed in the context of vector spaces. In this way, a distance-based method to build phylogenies has been developed and implemented into an easy-to-use R package. Tests run on real-world datasets show that this method can reconstruct phylogenetic relationships with high accuracy, and often outperforms other alignment-free approaches. Furthermore, we present evidence that the new method can perform reliably on datasets formed by non-orthologous protein sequences, that is, the method not only does not require the identification of orthologous proteins, but also does not require their presence in the analyzed dataset. These results suggest that the neighborhood preference of amino acids conveys a phylogenetic signal that may be of great utility in phylogenomics.
A Novel Method for Basic Reproduction Ratio of a Size-Structured Population Model with Delay
Authors: Kumar Manoj , Abbas Syed , Tridane Abdessamad 
Published: January 2022

Abstract
In this paper, we discuss a size-structured population model with a delay in birth process. The focus is to discuss the existence and uniqueness results along with basic reproduction ratio ( R 0 ). The birth function h is not necessarily a Ricker type of function but expression of R 0 obtained in this paper works for a more general function h . This analysis covers a larger class of models. The problem is converted into an abstract form and then theory of semigroup is used to obtain the results. The basic reproduction number is constructed as spectral radius of the next generation operator. The form for basic reproduction ratio is very general and can be applied to other problems as well. We also solve our model numerically to study the effect of delay on population distribution.
Practical Utility of Liver Segmentation Techniques in Clinical Surgeries and Interventions
Authors: Dakua Sarada Prasad , Ansari Mohammed Yusuf , Abdalla Alhusain , Ansari Mohammed Yaqoob , Ansari Mohammed Ishaq , Malluhi Byanne , Mohanty Snigdha , Mishra Subhashree , Singh Sudhansu Sekhar , Balakrishnan Shidin , Abinahed Julien , Al-Ansari Abdulla 
Published: January 2022

Abstract
Medical images (e.g., magnetic resonance imaging (MRI) and computed tomography (CT)) provide critical information to the clinicians in order to diagnose pathology and plan interventions. Image segmentation is the first and foremost step taken by the clinicians while optimizing analytic diagnosis and treatment planning for interventions (e.g., transplantation and complete resection) and therapeutic procedures (e.g., radiotherapy, PVE, and embolization approaches), especially in hepatocellular carcinoma. Thus, segmentation techniques certainly impact the diagnosis and treatment outcomes. This paper studies the literature during the year 2012 until 2021 and reviews the segmentation methods classifying them into three categories based on their clinical utility (i.e., surgical and radiological interventions). The classification is based on the parameters such as precision, accuracy, location, liver condition, and other clinical considerations.
Genetic analysis of novel resistance sources and genome-wide association mapping identified novel QTLs for resistance to Zymoseptoria tritici, the causal agent of septoria tritici blotch in wheat
Authors: Mahboubi Mozghan , Talebi Reza , Mehrabi Rahim , Naji Amir Mohammad , Maccaferri Marco , Kema Gert H.J. 
Published: January 2022

Abstract
Septoria tritici blotch (STB) caused by Zymoseptoria tritici is one of the most important foliar diseases of wheat causing significant yield losses worldwide. In this study, a panel of bread wheat genotypes comprised 185 globally diverse genotypes were tested against 10 Z. tritici isolates at the seedling stage. Genome-wide association study (GWAS) using high-throughput DArTseq markers was performed and further gene expression analysis of significant markers trait association (MTAs) associated with resistance to STB was analyzed. Disease severity level showed significant differences among wheat genotypes for resistance to different Z. tritici isolates. We found novel landrace genotypes that showed highly resistance spectra to all tested isolates. GWAS analysis resulted in 19 quantitative trait loci (QTLs) for resistance to STB that were located on 14 chromosomes. Overall, 14 QTLs were overlapped with previously known QTLs or resistance genes, as well as five potentially novel QTLs on chromosomes 1A, 4A, 5B, 5D and 6D. Identified novel resistance sources and also novel QTLs for resistance to different Z. tritici isolates can use for pyramiding and development of durable resistance cultivars in future wheat breeding programs.
On the Suitability of Phillipsite-chabazite Zeolitite Rock for Ammonia Uptake in Water. Some General Zeolite Features and a Case Study From the Pescara River (Italy)
Authors: NOVEMBRE DANIELA , GIMENO DOMINGO , CALISTA MONIA , MANCINELLI VANIA , MICCADEI ENRICO 
Published: January 2022

Abstract
Ionic exchange tests have been performed on superficial wastewaters to remove ammonia by the use of a volcanic zeolitized rock from Lazio Region (Central Italy). The zeolitite (natural zeolite) is characterized by chabazite, phillipsite and minor amounts of sanidine, leucite and analcime. After preliminary column experiments in laboratory focused to determine the saturation time of the zeolitite, a pilot plant was built up on a little water course near the area of San Giustino channel (Abruzzo Region, Central Italy). Wastewaters, characterised by starting ammonia value ranging between 5 and 120 mg/l, were filtered with a zeolitic bed. The first experimental results indicate a positive ammonia reduction of about 80-90% and, in all cases, NH4+ concentration values under the EU law limits. A main purpose of this paper is to evidence that most of studies published on uptake of ammonia by means of zeolitite lead with clinoptilolite-dominant zeolitite despite the large availability and best performance of phillipsite-chabazite zeolites. Last but not least, a large number of published studies are of difficult comparison because of poor characterization of the zeolitite used.
What implementation strategies and outcome measures are used to transform health care organizations into learning health systems? A mixed methods review protocol
Authors: Somerville Mari , Cassidy Christine , Curran Janet , Rothfus Melissa , Sinclair Douglas , Rose Annette Elliot 
Published: January 2022

Abstract
Background

A learning health system framework provides an opportunity for health system restructuring to provide value-based health care. However, there is little evidence showing how to effectively implement a learning health system in practice.
Objective

A mixed methods review is proposed to identify and synthesize the existing evidence on effective implementation strategies and outcomes of LHS in an international context.
Methods

A mixed methods systematic review will be conducted following methodological guidance from JBI and PRISMA reporting guidelines. Six databases (CINAHL, Embase, Medline, PAIS, Scopus and Nursing at Allied Health Database) will be searched for terms related to learning health systems, implementation and evaluation measures. Three reviewers will independently screen the titles, abstracts and full texts of retrieved articles. Studies will be included if they are published in a peer reviewed journal and report on the implementation of a learning health system in any health care setting. Qualitative, quantitative or mixed methods study designs will be considered for inclusion. No restrictions will be placed on language or date of publication. Grey literature, reviews, conference proceedings and dissertations will be excluded. Data will be extracted from included studies using a standardized extraction form. One reviewer will extract all data and a second will verify. Critical appraisal of all included studies will be conducted by two reviewers. A convergent integration approach to data synthesis will be used, where qualitative and quantitative data will be synthesized separately and then integrated to present overarching findings. Data will be presented in tables and narratively.
Conclusion

This review will address a gap in the literature related to implementation of learning health systems. The findings from this review will provide researchers with a better understanding of how to design and implement learning health system interventions. This systematic review was registered in PROSPERO (CRD42022293348).
“A toy plane in my home office”: Mothers’ perceptions of the reflections of the COVID-19 pandemic on their family relations and children’s play behaviours
Authors: Erbas Aysin Noyan , Seyhan Gamze Bilir , Ogul İrem Gurgah 
Published: January 2022

Abstract
BackgroundCoronavirus disease 2019 (COVID-19) pandemic which promotes social distance and hygiene measures affected children’s social life and mental health. Very little is currently known about how the pandemic changed the children’s family relations and plays. The aim of this study is to reveal the impact of the COVID-19 pandemic on family relations and young children’s play behaviors.MethodsFocus group interview was conducted with five mothers of 36 month-old children. Data were analyzed using content analysis.ResultsAnalysis revealed three main themes that (i) understanding the COVID-19, (ii) reflections of the COVID-19 outbreak on the family relations, (iii) reflections of the COVID-19 outbreak on the children’s play and play materials. Children had knowledge about COVID-19 with exposure to news and changing home routines and from explanations of family members. Pandemic restrictions had positive and negative impacts on the family relations. Satisfaction from parenting, being together with family members and children’s receiving more input from their parents and environment were evaluated as positive impacts of pandemic restrictions while parents’ feeling psychologically overwhelmed, children’s exposing oppressive behaviors and having developmental regression reflected to the family relationships negatively. Children’s plays included many concepts related to COVID-19. They experienced the restriction of their outdoor play and bringing some equipments for parks to provide hygiene. There was an increase in screen interaction and the number of toys. Children who deprived from their peers learned how they can interact and play with their peers without any contact.ConclusionsPandemic outbreak had a wide range of negative and positive consequences on family life practices, parents’ emotional well-being, children’s play patterns. These findings can help find effective ways to conserve and promote children’s and their families’ health in pandemic and recovery process.
Product Comparison for Slow and Fast Pyrolysis of Flax Shive
Authors: Lugovoy Yury V. , Chalov Kirill V. , Stepacheva Antonina , Kositsov Yury Yu. , Sulman Mikhail G. 
Published: January 2022

Abstract
In the current work, a comparison of the composition and properties of products obtained by the slow and fast pyrolysis of flax shive is presented to evaluate the influence of the process mode on the thermal decomposition of agricultural waste. The thermogravimetric studies were carried out to estimate the temperature range of the decomposition of the feedstock main component (cellulose, hemicelluloses, and lignin) and to choose the pyrolysis temperature. It was found that the slow pyrolysis was found to provide the higher conversion depth of the feedstock resulting in the formation of gaseous and liquid products with higher calorific values (9.65 MJ/m3, and 16.51 MJ/kg respectively). Moreover, the solid residue of the slow pyrolysis was characterized by the higher surface area and narrow pore size distribution in comparison with that obtained by the fast process.
A Multi-step In Vitro Hemocompatibility Testing Protocol Recapitulating the Foreign Body Reaction to Nanocarriers
Authors: Perugini Valeria , Schmid Ruth , Morch Yrr , Texier Isabelle , Brodde Martin , Santin Matteo 
Published: January 2022

Abstract
The development of drug nanocarriers based on polymeric, lipid and ceramic biomaterials has been paving the way to precision medicine where the delivery of poorly soluble active compounds and personalised doses are made possible. However, the nano-size character of these carriers has been demonstrated to have the potential to elicit pathways of the host response different from those of the same biomaterials when engineered as larger size implants and of the drugs, when administered without carrier. Therefore, a specific regulatory framework needs to be made available that can offer robust scientific insights and provide safety data by reliable tests of these novel nano-devices. In this context, the present work presents a multi-step protocol for the in vitro assessment of the hemocompatibility of nanocarriers of different physicochemical properties. Poly (EthylButyl Cyanoacrylate) nanoparticles and lipid-based (LipImage TM 815) nanoparticles of comparable hydrodynamic diameter were tested through a battery of assays using human peripheral blood samples and recapitulating the main pathways of the host response upon systemic administration; i.e. protein interactions, fibrinogen-platelet binding, cytotoxicity and inflammatory response. The data showed the sensitivity and reproducibility of the methods adopted that were also demonstrated to determine individual variability as well as to discriminate between activation of pathways of inflammation and unintended release of inflammatory signalling caused by loss of cell integrity. Therefore, this multi-step testing is proposed as a reliable protocol for NP development and emerging regulatory frameworks.
Fertilization Strategies To Improve Crop Yields and N Use Efficiency Depending on Soil pH in Chinese Cabbage-Maize Rotation
Authors: Xie Jun , Evgenia Blagodatskaya , Zhang Yu , Wang Jie , Wan Yu , Shi Xiao-jun 
Published: January 2022

Abstract
Aims
The efficiency of fertilizer nitrogen (N) use strongly depends on soil pH and affects both agricultural production and environmental pollution control. However, the effect of soil pH on N use efficiency (NUE) remains unclear.
Methods
We compared crop yield, N uptake, NUE, and the N input-output balance in a Chinese cabbage-maize cropping system in a field experiment from 2011 to 2016 along a pH gradient (alkaline (pH 8.32), near-neutral (pH 6.56) and acidic soil (pH 5.91)).
Results
Mineral fertilization had the worst effect in acidic soils, because it significantly decreased soil pH, as well as decreased crop yield, N uptake, and NUE. Combined chicken manure-mineral fertilization was most favorable irrespective of soil pH because it increased soil quality (e.g., high total N and organic C contents) and maintained a neutral soil pH. Chicken manure treatment was most appropriate in acidic soils because it increased pH by 2.03 units, up to 13% crop yield, and increased N uptake and NUE than that in alkaline and near-neutral soils. Under manure treatments, the N surplus was the lowest in acidic soil. Under mineral fertilization, however, the N surplus in acidic soil was the highest.
Conclusions
We conclude that combined organic-mineral fertilization in alkaline, near-neutral, and acidic soils is a promising strategy that not only increases the crop yield, N uptake, and NUE but also decreases the N surplus. Manure fertilization is also recommended as an efficient strategy in acidic soils to increase crop yield and NUE by improving soil pH.