bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐Swelling, Robust, and Adhesive Extracellular Matrix‐Mimicking Hydrogel Used as Intraoral Dressing
Authors: Wu Jing , Pan Zhao , Zhao Zheng‐Yi , Wang Mo‐Han , Dong Liang , Gao Huai‐Ling , Liu Chong‐Yuan , Zhou Pu , Chen Lu , Shi Chao‐Ji , Zhang Zhi‐Yuan , Yang Chi , Yu Shu‐Hong , Zou Duo‐Hong 
Published: February 2022

AbstractDue to the wet and dynamic environment of the oral cavity, the healing of intraoral wounds, such as tooth extraction wounds, requires stable and firm wound dressings. In clinical practice, cotton balls and gauzes, sponge plugs, or sutures are used to treat extraction wounds, but none of these means can continuously isolate the wound from the intraoral environment and facilitate ideal healing conditions. Herein, inspired by the natural extracellular matrix, a family of wound dressings is developed for intraoral wound repair. Infiltrating a ductile long‐chain hydrogel network into a prefabricated, sturdy macromolecular meshwork and in situ crosslinking endowed the composite hydrogel with controllable swelling behaviors and robust mechanical properties. The macromolecular meshwork functioned as the backbone to support the composite and restricts the swelling of the long‐chain hydrogel network. In vitro tests verified that this wound dressing can provide durable protection for intraoral wounds against complex irritations. Furthermore, accelerated wound healing occurred when the wound dressing is applied in vivo on a canine tooth extraction model, due to the effective reduction of acute inflammation. These results suggest that this family of bioinspired hydrogels has great potential for application as intraoral wound dressing.
Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array
Authors: Yi Guangshun , Gao Shujun , Lu Hongfang , Khoo Wei Zhi , Liu Shaoqiong , Chng Shuyun , Yang Yi Yan , Ying Jackie Y. , Zhang Yugen 
Published: February 2022

AbstractVertically aligned layered double hydroxide (V‐LDH) array has been growing on various substrates by a simple solution hydrolysis method. The surface shows good topology with LDH edges extending upward, which can potentially rupture the attached bacteria cells and kill them. V‐LDH after calcination shows remarkable enhanced antibacterial properties. Not only do the edges become thinner and sharper, the surface also becomes highly hydrophilic. It is found that surface potential of V‐LDH does not change its antibacterial property. However, the hydrophilicity significantly enhances antibacterial properties. In vitro and in vivo studies demonstrate that the V‐LDH surface has good biocompatibility. The V‐LDH antibacterial coating has potentially broad applications due to its good antibacterial properties and biocompatibility.
Mechanical Behavior of Blisters Spontaneously Formed by Multilayer 2D Materials
Authors: Wang Wenxiang , Ma Xiaojie , Dai Zhaohe , Zhang Shuai , Hou Yuan , Wang Guorui , Li Qunyang , Zhang Zhong , Wei Yueguang , Liu Luqi 
Published: February 2022

AbstractBlisters can form spontaneously when transferring 2D materials on a substrate because of the small molecules trapped at the interface. Though extensive works have revealed a characteristic aspect ratio of these blisters by neglecting the bending effect of the layer, how the bending comes into play as the layer number increases has not been fully understood. Here, by simply measuring the profiles of blisters formed by transferred multilayer graphene and MoS2 sheets, the variable profiles of blisters and the transition of their characteristic shape from a constant aspect ratio to a constant dome curvature are observed. Taking variable profiles of blisters and different characteristics of the interface into consideration, a theoretical model is established, and the mechanism of such transition is further analytically unveiled. In addition, based on this theory, the bending stiffness of sheets and the adhesion energy between sheets and substrates can be obtained simultaneously. This method is simple but robust, providing a new experimental way to explore the mechanical behavior of 2D material structures.
Enhanced Efficiency and Stability of Carbon‐Based Perovskite Solar Cells by Eva Interface Engineering
Authors: Wang Haobin , Qiang Yue , Zheng Shenshen , Wei Peng , Xie Yahong 
Published: February 2022

AbstractNanocrystalline tin (IV) oxide (SnO2) as an electron‐transport layer (ETL) has unique advantages in realizing highly efficient and stable planar perovskite solar cells (PSCs), especially showing great potential in the low‐temperature preparation of large‐area flexible carbon‐based PSCs (C‐PSCs). However, the high trap density on the surface of SnO2 tends to cause serious nonradiative recombination losses, thereby reducing photoelectric performance. In this work, an inexpensive and easily obtained polymer poly(ethylene‐co‐vinyl acetate) (Eva) is used as a interfacial modifier to reduce the interfacial defects and nonradiative recombination losses at the SnO2/perovskite interface. As a result, the crystallinity and conductivity of the perovskite layer are significantly increased, and the charge lifetime and stability are effectively improved. The Eva modified SnO2‐based C‐PSCs obtain an optimal power conversion efficiency (PCE) of 12.29%, which is 25.7% higher than that of 9.78% for the unmodified C‐PSCs. Furthermore, the unencapsulated devices maintain 88.6% and 91.9% of the initial PCE over 1 month in ambient air for the unmodified and Eva‐modified C‐PSCs, respectively. The study provides valuable experience for the development of highly efficient and stable C‐PSCs using common polymers for interface modification engineering.
Self‐Induced Solutal Marangoni Flows Realize Coffee‐Ring‐Less Quantum Dot Microarrays with Extensive Geometric Tunability and Scalability
Authors: Pyeon Jeongsu , Song Kyeong Min , Jung Yeon Sik , Kim Hyoungsoo 
Published: February 2022

AbstractCurrently, quantum dot light‐emitting diodes (QD‐LEDs) are receiving extensive attention. To maximize their luminous performance, the uniformity of the QD‐LEDs is crucial. Although the spontaneously self‐induced solutal Marangoni flow of an evaporating binary mixture droplet has been widely investigated and used to suppress coffee‐ring patterns in ink‐jet printing technology, unfortunately, ring shapes are still present at the edges, and the Marangoni flow generated by the selective evaporation of volatile liquid components cannot be controlled due to its nonlinear instabilities. In this work, polygonal coffee‐ring‐less QD microarrays are created using two spontaneous and sequential solutal Marangoni flows. During the initial evaporation, internal circulating flows are controlled by polygonal‐shaped droplets. After that, sequential interfacial flows are generated by the captured volatile vapors. A theoretical model and scaling analysis are provided to explain the working mechanisms. It is expected that the newly designed printing system can be applied to the mass production of QD‐LEDs.
Regenerating the Injured Spinal Cord at the Chronic Phase by Engineered iPSCs‐Derived 3D Neuronal Networks
Authors: Wertheim Lior , Edri Reuven , Goldshmit Yona , Kagan Tomer , Noor Nadav , Ruban Angela , Shapira Assaf , Gat‐Viks Irit , Assaf Yaniv , Dvir Tal 
Published: February 2022

AbstractCell therapy using induced pluripotent stem cell‐derived neurons is considered a promising approach to regenerate the injured spinal cord (SC). However, the scar formed at the chronic phase is not a permissive microenvironment for cell or biomaterial engraftment or for tissue assembly. Engineering of a functional human neuronal network is now reported by mimicking the embryonic development of the SC in a 3D dynamic biomaterial‐based microenvironment. Throughout the in vitro cultivation stage, the system's components have a synergistic effect, providing appropriate cues for SC neurogenesis. While the initial biomaterial supported efficient cell differentiation in 3D, the cells remodeled it to provide an inductive microenvironment for the assembly of functional SC implants. The engineered tissues are characterized for morphology and function, and their therapeutic potential is investigated, revealing improved structural and functional outcomes after acute and chronic SC injuries. Such technology is envisioned to be translated to the clinic to rewire human injured SC.
Emerging New‐Generation Detecting and Sensing of Metal Halide Perovskites
Authors: Bu Hui , He Caili , Xu Yanqing , Xing Lu , Liu Xiaomin , Ren Shuxia , Yi Shenghui , Chen Liang , Wu Hao , Zhang Guanglei , Zhao Jinjin , Shi Jianlin 
Published: February 2022

AbstractThe unique energy conversion characteristics of metal halide perovskite (MHP) materials, which can be hardly observed in conventional semiconductors and metal oxides, have boosted their promising application in detecting and sensing devices, in addition to their famous optoelectronic functions. Herein, the recent progresses of the state‐of‐the‐art applications of MHPs are focused on X‐ray diagnosis, cardiac detection, bionic retina, artificial synapse, cell imaging, and others. Owing to their emerging electrical properties with multifield coupled response effect, and photoelectric, electro‐optical, and all‐optical conversion functions, MHPs demonstrate promising prospects in the diagnosis and treatment of various diseases. As functional optoelectronic materials, MHPs provide a new platform for future biomedical devices. This review article is expected to present the current status on, and further promote the application of MHP materials in detecting and sensing devices.
Highly Active and Durable Air Electrodes for Reversible Protonic Ceramic Electrochemical Cells Enabled by an Efficient Bifunctional Catalyst
Authors: Niu Yinghua , Zhou Yucun , Zhang Weilin , Zhang Yanxiang , Evans Conor , Luo Zheyu , Kane Nicholas , Ding Yong , Chen Yu , Guo Xuyun , Lv Weiqiang , Liu Meilin 
Published: February 2022

AbstractThe commercialization of reversible protonic ceramic electrochemical cells is hindered by the lack of highly active and durable air electrodes exposed to high concentration of steam under operating conditions. Here, findings that dramatically enhance the electrocatalytic activity and stability of a conventional (La0.6Sr0.4)0.95Co0.2Fe0.8O3−δ (LSCF) air electrode by a multiphase catalyst coating composed of a conformal Pr1−xBaxCoO3−δ thin film and exsolved BaCoO3−δ nanoparticles, are reported. At 600 °C, the catalyst coating decreases the polarization resistance of the LSCF air electrode by a factor of 25 (from 1.09 to 0.043 Ω cm2) in air and the degradation rate by two orders of magnitude (from 1.0 × 10−2 to 1.8 × 10−4 Ω cm2 h−1 in humidified air with 30 vol% H2O). Further, a single cell with the catalyst‐coated LSCF air electrode at 600 °C demonstrates a high peak power density of 1.04 W cm−2 in the fuel cell mode and a high current density of 1.82 A cm−2 at 1.3 V in the electrolysis mode. The significantly enhanced performance of the LSCF air electrode is attributed mainly to the high rate of surface oxygen exchange, fast surface proton diffusion, and the rapid H2O and O2 dissociation on the catalysts.
Diagnostic outcomes for molecular genetic testing in children with suspected Ehlers–Danlos syndrome
Authors: Damseh Nadirah , Dupuis Lucie , O'Connor Constance , Oh Rachel Youjin , Wang Yi Wen , Stavropoulos Dimitri James , Schwartz Sarah B. , Mendoza‐Londono Roberto 
Published: February 2022

AbstractEhlers–Danlos syndrome (EDS) is a heterogeneous group of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, easy bruisability, and fragility of the connective tissues. The diagnosis is based on clinical assessment and phenotype‐guided genetic testing. Most EDS subtypes can be confirmed by genetic testing except for hypermobile EDS. This study explored the utility of applying the 2017 EDS classification criteria and molecular genetic testing in establishing an EDS diagnosis in children. In this retrospective study, we reviewed 72 patients referred to a tertiary care center for evaluation of EDS who underwent one or more forms of genetic testing. Eighteen patients (18/72, 25%) met the clinical criteria for one of the EDS subtypes and of these, 15 (15/18, 83%) were confirmed molecularly. Fifty‐four patients (54/72, 75%) had features that overlapped EDS and other syndromes associated with joint hypermobility but did not fully meet clinical criteria. Twelve of them (12/54, 22%) were later shown to have a positive molecular genetic diagnosis of EDS. Different molecular genetic tests were performed on the cohort of 72 patients (EDS panel, n = 44; microarray, n = 25; whole exome sequencing [WES], n = 9; single gene sequencing, n = 3; familial variant testing, n = 10; other genetic panels n = 3). EDS panel was completed in 44 patients (61%), and a molecular diagnosis was confirmed in nine of the patients who satisfied criteria for one of the EDS subtypes (9/12, 75%) and in nine of the patients who did not fully meet criteria (9/32, 28%). We observed a correlation between generalized joint hypermobility, poor healing, easy bruising, atrophic scars, skin hyperextensibility, and developmental dysplasia of the hip with a positive molecular result. This study provides guidance for the use of molecular genetic testing in combination with the 2017 clinical diagnostic criteria in children presenting with EDS characteristics.
Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
Authors: Zheng Jie 
Published: February 2022

AbstractAdult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro‐neurogenic therapies including rescuing innate AHN, cell engraftment and glia‐neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro‐neurogenic remedies.
Coloration in Supraparticles Assembled from Polyhedral Metal‐Organic Framework Particles
Authors: Wang Junwei , Liu Yang , Bleyer Gudrun , Goerlitzer Eric S. A. , Englisch Silvan , Przybilla Thomas , Mbah Chrameh Fru , Engel Michael , Spiecker Erdmann , Imaz Inhar , Maspoch Daniel , Vogel Nicolas 
Published: February 2022

AbstractSupraparticles are spherical colloidal crystals prepared by confined self‐assembly processes. A particularly appealing property of these microscale structures is the structural color arising from interference of light with their building blocks. Here, we assemble supraparticles with high structural order that exhibit coloration from uniform, polyhedral metal–organic framework (MOF) particles. We analyse the structural coloration as a function of the size of these anisotropic building blocks and their internal structure. We attribute the angle‐dependent coloration of the MOF supraparticles to the presence of ordered, onion‐like layers at the outermost regions. Surprisingly, even though different shapes of the MOF particles have different propensities to form these onion layers, all supraparticle dispersions show well‐visible macroscopic coloration, indicating that local ordering is sufficient to generate interference effects.
A zinc porphyrin polymer as efficient bifunctional catalyst for conversion of CO2 to cyclic carbonates
Authors: Su Zhenping , Ma Linjing , Wei Jiaojiao , Bai Xiaolong , Wang Ning , Li Jun 
Published: February 2022

AbstractThe design and synthesis of efficient heterogeneous catalysts for catalytic conversion of CO2 are an important challenge. The novel zinc porphyrin polymer reported herein, [ZnPy+CPP‐BTA]I−, is synthesized from trans‐A2B2 porphyrin precursor 5,15‐(4‐carboxyphenyl)‐10,20‐(pyridyl)‐porphyrin (PyCPP) and 1,2,4,5‐benzenetetramine tetrahydrochloride (BTA), employing a sequential post‐synthetic methylation and metalation strategy. The newly synthesized zinc porphyrin polymer was well characterized by Fourier transform infrared spectroscopy (FT‐IR), Ultraviolet–visible spectroscopy (UV–vis), scanning electron microscope (SEM), transmission electron microscope (TEM), thermal gravimetric analysis (TGA), and X‐ray photoelectron spectroscopy (XPS). As bifunctional heterogeneous catalyst incorporated zinc porphyrin and nucleophile I−, [ZnPy+CPP‐BTA]I− shows good catalytic activity and recyclability for the cycloaddition reactions of epoxides and CO2 under lower CO2 initial pressure and cocatalyst‐free conditions.
Preparation and Photoluminescent Properties of Amino 2,1,3‐Benzoxadiazoles (Am‐BODs) with D‐A‐D and D‐A‐A Conjugation Systems
Authors: Li Hanjie , Wang Zhichao , Wang Zaibin , Wang Yanguang , Lu Ping 
Published: February 2022

AbstractA series of D‐A‐D and D‐A‐A conjugated compounds composed of a benzoxadiazole core and corresponding amino moiety were synthesized. Their photoluminescent properties in different states were investigated as well. In the solution state, some compounds were observed to possess the usual anti‐Kasha's emission in toluene and the solvatofluorochromic phenomenon. Meanwhile, compound 1 a could be utilized as fluorescent chemosensor for the environmental acidity, and 2 c could be developed for detecting fluoride anion. Moreover, they were emissive in powders and films, and 2 d could be applied to the emissive layer in red OLEDs.
Strategic sustainability integration: Merging management tools to support business model decisions
Authors: Silvestre Winston Jerónimo , Fonseca Ana , Morioka Sandra Naomi 
Published: February 2022

AbstractDespite the competitive advantages of sustainable business models, developing management solutions to systematically support sustainability integration into organizational strategy is still a challenging approach for most organizations. Based on a critical analysis of existing tools to support sustainable business models, the present paper describes the development of a practical management tool to guide the strategic integration of sustainability in organizational business models. The proposed management tool results from the synergistic combination of the Sustainable Value Exchange Matrix and the Integrative Sustainable Intelligence Model, in a cyclic and continuous process supported by the periodic diagnosis of the key organizational factors with relevance for successful sustainability integration processes. The management tool described in this paper is expected to guide the strategic adaptation of organizations toward results with a positive impact on sustainability, with an effective contribution to the development of more sustainable business models.
Development of an authentic concept of engineering activities based on product redesign
Authors: Akerdad Mohammed , Aboutajeddine Ahmed , Elmajdoubi Mohammed 
Published: February 2022

AbstractToday's job market is seeking engineers with competencies to design innovative solutions that meet sophisticated customer needs. Engineering education is then challenged to equip future engineers with holistic engineering design skills, especially functional ones. A powerful means to strengthen these skills is the use of reverse‐engineering‐based activities, which consist of examining, extracting information, and redesigning existing products. However, most current education endeavours, based on reverse engineering, consist only of practicing simple teardowns that have circumscribed impact on the acquisition of skills. Therefore, there is a need for more elaborated authentic hands‐on activities to gain a broad set of design skills. This study addresses this gap by the development of a concept of wide‐ranging engineering activities that start with the study of an existing product and ends with an improved redesigned three‐dimensional (3D) printed product. This concept of activities was developed to strengthen a conventional course on product design. Thus, a tailored comprehensive redesign process is proposed first, and expanded as a concept of a set of experiential activities, with associated measures for skills acquisition. This concept encompasses teardown, 3D digitizing and rapid prototyping, and aims mainly at facilitating the understanding of components' functionalities, the numerical reconstruction by 3D digitizing, the mechanical modelling and engineering analysis of parts and finally the 3D printing of the redesign output. To understand, experience, and weigh up the relevance of the proposed concept of activities, a preliminary implementation, and a case study are illustrated. Particularly, the relevance of the concept is demonstrated through the assessment of the activities' measures. In short, this study provides educators with an authentic education tool that leverages on a broader reverse engineering vision to boost the job's sought‐after design skills.
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway
Authors: Ying Jun , Pan Ruowang , Tang Zhouhao , Zhu Jiayin , Ren Ping , Lou Yang , Zhang Enyong , Huang Dadao , Hu Penghong , Li Dong , Bao Qiyu , Li Peizhen 
Published: February 2022

AbstractBackgroundNucleolin (NCL, C23) is a multifunctional phosphoprotein that plays a vital role in modulating the survival, proliferationand apoptosis of cancer cells. However, the effects of NCL on cervical cancer and the underlying mechanisms behind this are poorly understood.MethodsLentiviral transfection technology was used to construct NCL knockdown cell lines. MTT, colony formation assays, and tumorigenic assays in vivo were performed to observe cell proliferation. HOECHST 33342 staining, flow cytometry, and caspase activity assay were used to test cell apoptosis. RNA‐Seq, Western blotting, and RT‐PCR were conducted to investigate the specific molecular mechanism.ResultsNCL knockdown inhibited cell proliferation and promoted apoptosis both in vivo and in vitro. Mechanistic studies revealed that NCL knockdown inhibited the PI3K/AKT pathway by upregulating FGF, ITGA, TNXB, VEGF, Caspase 3, and Bax, as well as by downregulating AKT, GNB4, CDK6, IL6R, LAMA, PDGFD, PPP2RSA and BCL‐2. In addition, the expression levels of apoptosis‐related genes after using a PI3K inhibitor LY294002 were consistent with shRNA studies, while treatment with a 740Y‐P agonist showed the opposite effect.ConclusionsOur findings indicate that downregulation of NCL may be a novel treatment strategy forcervical cancer.