bluuebunny/crossref_metadata_2025_split huggingface dataset:
The simulation of terrible triad injuries in fresh-frozen human cadaveric specimens with intact soft tissue envelope
Authors: Lanzerath Fabian , Knifka Jutta , Leschinger Tim , Ott Nadine , Kahmann Stephanie , Hackl Michael , Müller Lars P. , Wegmann Kilian 
Published: December 2022

Abstract
Introduction
The aim of the present study was to develop a technical process to reproducibly generate terrible triad injuries (TTI) in fresh-frozen human cadaveric specimens, while leaving the skin intact. Such “pre-fractured” specimens, used for scientific analysis and for surgical education, might help to improve current treatment, which is complex and prone to complications.

Materials and methods
To induce the desired fractures, a custom-made fracturing unit was used to apply an axial force on the extended cadaveric elbow specimens, with the forearm pronated and under valgus load. To simulate the valgus load, a pneumatic cylinder was developed to apply valgus stress to the joint by an additional force vector from the lateral side of the joint.

Results
The success rate of TTI induction was 92.3% (12/13). Of the 12 radial head fractures, 3 (25%) were classified Mason type II and 9 (75%) Mason type III. The coronoid fractures were grouped in tip subtype 2 (5 fractures, 41.7%), anteromedial facet (AMF) subtype 2 (4 fractures, 33.3%), AMF subtype 3 (1 fracture, 8.3%) and basal subtype 1 (2 fractures, 16.7%).

Conclusions
The present study provides an instrument for successful and reproducible production of dislocation fracture patterns with their typical accompanying soft tissue lesions. The methodology might be applied on a broad basis to be able to perform biomechanical studies regarding primary stability of fixation concepts for TTI and to educate surgeons in a fairly realistic scenario with the surgical treatment of TTI.
Building infrastructure for outcomes-based agreements in Canada: can administrative health data be used to support an outcomes-based agreement in oncology?
Authors: Cheung Winson Y. , Cameron Chris , Mitha Arif , Wills Allison 
Published: December 2022

Abstract

Background
Outcomes-based agreements (OBAs) have the potential to provide more timely patient access to novel therapies, although they are not suitable for every new medication or reimbursement scenario. The authors of this paper studied how to operationalize an OBA in oncology by leveraging existing real-world data (RWD) infrastructure in the province of Alberta.

Objective
The main objectives were to (1) evaluate which health outcomes in oncology are suitable for OBAs and whether they can be tracked with existing infrastructure, and (2) determine how RWD in oncology can be used to implement an OBA and the expected timing for delivery.

Methods
Using the Oncology Outcomes (O2) Group infrastructure and Alberta administrative data, a review of five key oncology outcomes was performed to determine suitability to support an OBA.

Results
Overall survival and time-to-next-treatment were determined as potentially suitable oncology outcomes for OBAs; progression-free survival, patient-reported outcomes, and return to work were deemed inadequate for OBAs at the current time due to data limitations.

Conclusions
Results indicate that it is feasible to leverage RWD to support OBAs in oncology in Alberta, with minimal additional data, resources, and infrastructure. The operational processes and steps to collect and analyze RWD for OBAs were identified, starting with performing an RWD feasibility study. The expected timeframe to fulfill the real-world evidence (RWE) requirements for an OBA is approximately 3 years for cancers with short trajectories.
Der Preis der Psychotherapie – Argumente für eine Wiederbelebung der sozialen Perspektive im psychotherapeutischen Denken und Handeln
Authors: Gahleitner Silke Birgitta , Giertz Karsten , Caspari Cornelia , Caspari Peter , Keupp Heiner 
Published: December 2022

ZusammenfassungDurch die Einführung der Richtlinienpsychotherapie in Deutschland im Jahr 1998 wurde eine psychotherapeutische Regelversorgung etabliert, die psychische Problemlagen auf der eindimensionalen Grundlage der ICD ohne Einbeziehung von wichtigen Konzepten wie Lebenswelt, Sozialraum oder Ressourcenorientierung betrachtet. Gesellschaftliche Einflüsse auf psychische Gesundheit und Krankheit spielen nur eine marginale Rolle. Die Behandlung ist ausschließlich von einer spezifischen ICD-Diagnose abhängig, alternative Behandlungsansätze sind aus der Regelversorgung systematisch ausgeschlossen. Effektivitätsnachweise sind strikt an RCT-Studien gekoppelt. Dadurch werden Patient_innen mit komplexen psychischen Problemlagen von der psychotherapeutischen Versorgung nur marginal erfasst. Neben einer kritischen Analyse zur aktuellen psychotherapeutischen Versorgung in Deutschland arbeiten die Autor_innen die Folgen dieser Entwicklung am Beispiel von gewaltbetroffenen Patient_innen und onkologischen Patient_innen heraus. Im Anschluss diskutieren sie notwendige Veränderungen innerhalb der Praxis und Profession der Psychotherapie.
Cluster-based stability evaluation in time series data sets
Authors: Klassen Gerhard , Tatusch Martha , Conrad Stefan 
Published: December 2022

AbstractIn modern data analysis, time is often considered just another feature. Yet time has a special role that is regularly overlooked. Procedures are usually only designed for time-independent data and are therefore often unsuitable for the temporal aspect of the data. This is especially the case for clustering algorithms. Although there are a few evolutionary approaches for time-dependent data, the evaluation of these and therefore the selection is difficult for the user. In this paper, we present a general evaluation measure that examines clusterings with respect to their temporal stability and thus provides information about the achieved quality. For this purpose, we examine the temporal stability of time series with respect to their cluster neighbors, the temporal stability of clusters with respect to their composition, and finally conclude on the temporal stability of the entire clustering. We summarise these components in a parameter-free toolkit that we call Cluster Over-Time Stability Evaluation (CLOSE). In addition to that we present a fuzzy variant which we call FCSETS (Fuzzy Clustering Stability Evaluation of Time Series). These toolkits enable a number of advanced applications. One of these is parameter selection for any type of clustering algorithm. We demonstrate parameter selection as an example and evaluate results of classical clustering algorithms against a well-known evolutionary clustering algorithm. We then introduce a method for outlier detection in time series data based on CLOSE. We demonstrate the practicality of our approaches on three real world data sets and one generated data set.
CINWA (database of terminology for cultivated plants in indigenous languages of northwestern South America): introducing a resource for research in ethnobiology, anthropology, historical linguistics, and interdisciplinary research on the neolithic transition in South America
Authors: Urban Matthias , Panchi Evelyn Michelle Aguilar , Lee Saetbyul , Brodetsky Evgenia 
Published: December 2022

AbstractThis article introduces CINWA, a freely accessible online database of terminology for cultivated plants in indigenous languages of South America based on FAIR principles for scientific data management and stewardship. In the pre-release version we present here, CINWA assembles more than 2700 terms from more than 60 indigenous languages of northwestern South America, and coverage will be continuously expanded. CINWA is primarily designed for use in historical linguistics to explore patterns of lexical borrowing that might be used as a proxy for tracing the pathways by which knowledge of individual cultivated plants and the associated know-how spread from speech community to speech community in pre-Columbian South America. In spite of intensifying research, this is still unclear for most cultivars as the locales of initial cultivation are heterogeneous and spatially diffuse. However, possible uses of the CINWA database are manifold and go beyond this research question. The database can be used as a resource for ethnobiological and comparative anthropological research on South American communities, South American agricultural ecosystems and practices, and for studies in lexical borrowing, language contact, and historical linguistics broadly.
Impact of Mass Timber Compartment Fires on Façade Fire Exposure
Authors: Engel Thomas , Werther Norman 
Published: December 2022

AbstractThis study investigates whether timber surfaces that are initially exposed to fire or partially protected timber components can lead to a more critical fire exposure on the façade. Five full-scale fire tests were carried out. Three tests with a square compartment (4.5 × 4.5 m2) and two with a double-width compartment (4.5 × 9 m2). The tests were conducted with a high fire load density (1085 MJ/m2). While the first test was carried out in a non-combustible compartment, the exposed timber surfaces were subsequently increased in the other tests. The measured compartment gas temperature, heat release rate, temperature on the façade, flame heights along the façade, heat flux and velocities along the façade are presented in this publication. The influence of exposed or only initially protected timber surfaces on the fire impact on the façade is investigated with the help of these results. Finally, these findings are presented and compared with the results of other internationally conducted fire tests from literature. Additional structural fire load leads to an increase in temperatures on the façade. However, there is no significant difference in flame height between the tests. Another result was that an exposed mass timber ceiling leads to higher heat fluxes on the façade than an exposed mass timber wall.
Graphical Abstract
Design of Quick Search Method for Key Feature Images in Mobile Networks
Authors: Zheng Jingya , Woźniak Marcin 
Published: December 2022

AbstractIn order to promote the efficiency of image retrieval in mobile network and realize the fast query of key images, this paper designs a quick search method of key feature images in mobile networks. The key features of retrieved images are extracted by rotation invariant local binary method. According to the extracted key features of the image, the query target image is processed by coarse quantization then the distance of the key features of the image is calculated and retrieved. Finally, non-exhaustive search method is used to achieve quick search of key feature images in mobile network. Experimental results show that this method can effectively extract specific images, The desired image can be quickly searched by reserved key features, and the F-score value of quick search is higher than 0.9.
Landing control method of a lightweight four-legged landing and walking robot
Authors: Yin Ke , Qi Chenkun , Gao Yue , Sun Qiao , Gao Feng 
Published: December 2022

AbstractThe prober with an immovable lander and a movable rover is commonly used to explore the Moon’s surface. The rover can complete the detection on relatively flat terrain of the lunar surface well, but its detection efficiency on deep craters and mountains is relatively low due to the difficulties of reaching such places. A lightweight four-legged landing and walking robot called “FLLWR” is designed in this study. It can take off and land repeatedly between any two sites wherever on deep craters, mountains or other challenging landforms that are difficult to reach by direct ground movement. The robot integrates the functions of a lander and a rover, including folding, deploying, repetitive landing, and walking. A landing control method via compliance control is proposed to solve the critical problem of impact energy dissipation to realize buffer landing. Repetitive landing experiments on a five-degree-of-freedom lunar gravity testing platform are performed. Under the landing conditions with a vertical velocity of 2.1 m/s and a loading weight of 140 kg, the torque safety margin is 10.3% and 16.7%, and the height safety margin is 36.4% and 50.1% for the cases with or without an additional horizontal disturbance velocity of 0.4 m/s, respectively. The study provides a novel insight into the next-generation lunar exploration equipment.
Central Nervous System Prophylaxis and Treatment in Acute Leukemias
Authors: Wu Susan Y. , Short Nicholas J. , Nasr Lewis , Dabaja Bouthaina S. , Fang Penny Q. 
Published: December 2022

Opinion statementImprovements in systemic therapy in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) have improved patient outcomes and reduced the incidence of CNS relapse. However, management of patients with CNS disease remains challenging, and relapses in the CNS can be difficult to salvage. In addition to treatment with CNS-penetrant systemic therapy (high-dose methotrexate and cytarabine), intrathecal prophylaxis is indicated in all patients with ALL, however is not uniformly administered in patients with AML without high-risk features. There is a limited role for radiation treatment in CNS prophylaxis; however, radiation should be considered for consolidative treatment in patients with CNS disease, or as an option for palliation of symptoms. Re-examining the role of established treatment paradigms and investigating the role of radiation as bridging therapy in the era of cellular therapy, particularly in chemotherapy refractory patients, is warranted.
States of Uncertainty, Risk–Benefit Assessment and Early Clinical Research: A Conceptual Investigation
Authors: Schnarr Antje , Mertz Marcel 
Published: December 2022

AbstractIt can be argued that there is an ethical requirement to classify correctly what is known and what is unknown in decision situations, especially in the context of biomedicine when risks and benefits have to be assessed. This is because other methods for assessing potential harms and benefits, decision logics and/or ethical principles may apply depending on the kind or degree of uncertainty. However, it is necessary to identify and describe the various epistemic states of uncertainty relevant to such estimates in the first place. Therefore, this paper aims to develop a category system of different epistemic states of uncertainty which, although not exclusively, is primarily intended to be applied to early clinical trials. It is formed on the basis—and various combinations—of three dimensions of uncertainty that represent certain parts of incomplete knowledge: outcome (type of event), probability (of outcome) and evaluation (assessment of outcome). Furthermore, it is argued that uncertainty can arise from three different sources (the structure of the object of research, the state of the evidence, or individual handling of the research and already existing knowledge). The categories developed are applied to actual examples from gene therapy and genome editing to illustrate that they can be helpful for a more precise definition of the respective uncertainties, especially in the context of risk–benefit assessment. The categories allow a differentiated perspective of decision-making situations from the point of view of incomplete knowledge in general, but particularly, for example, in early clinical research, and may thereby support a more acceptable ethical assessment of potential harms and benefits.
Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing
Authors: Amante Chiara , Andretto Valentina , Rosso Annalisa , Augusti Geraldine , Marzocco Stefania , Lollo Giovanna , Del Gaudio Pasquale 
Published: December 2022

AbstractThis work combines natural polymers with nanoemulsions (NEs) to formulate nanocomposites as an innovative wound dressing. Spray-drying has been used to produce alginate-pectin in situ gelling powders as carriers for NEs loaded with curcumin (CCM), a model antimicrobial drug. The influence of NEs encapsulation in polymer-based microparticles was studied in terms of particle size distribution, morphology, and stability after spray-drying. NEs loading did not affect the size of microparticles which was around 3.5 µm, while the shape and surface morphology analyzed using scanning electron microscope (SEM) changed from irregular to spherical. Nanocomposites as dried powders were able to form a gel in less than 5 min when in contact with simulated wound fluid (SWF), while the value of moisture transmission of the in situ formed hydrogels allowed to promote good wound transpiration. Moreover, rheologic analyses showed that in situ formed gels loaded with NEs appeared more elastic than blank formulations. The in situ formed gel allowed the prolonged release of CCM-loaded NEs in the wound bed, reaching 100% in 24 h. Finally, powders cytocompatibility was confirmed by incubation with keratinocyte cells (HaCaT), proving that such nanocomposites can be considered a potential candidate for wound dressings.
Graphical Abstract
Double Layer Composite Electrode Strategy for Efficient Perovskite Solar Cells with Excellent Reverse-Bias Stability
Authors: Jiang Chaofan , Zhou Junjie , Li Hang , Tan Liguo , Li Minghao , Tress Wolfgang , Ding Liming , Grätzel Michael , Yi Chenyi 
Published: December 2022

AbstractPerovskite solar cells (PSCs) have become the representatives of next generation of photovoltaics; nevertheless, their stability is insufficient for large scale deployment, particularly the reverse bias stability. Here, we propose a transparent conducting oxide (TCO) and low-cost metal composite electrode to improve the stability of PSCs without sacrificing the efficiency. The TCO can block ion migrations and chemical reactions between the metal and perovskite, while the metal greatly enhances the conductivity of the composite electrode. As a result, composite electrode-PSCs achieved a power conversion efficiency (PCE) of 23.7% (certified 23.2%) and exhibited excellent stability, maintaining 95% of the initial PCE when applying a reverse bias of 4.0 V for 60 s and over 92% of the initial PCE after 1000 h continuous light soaking. This composite electrode strategy can be extended to different combinations of TCOs and metals. It opens a new avenue for improving the stability of PSCs.
An unusual case of trichotillomania and trichophagia associated with authentic hair extension as seen in a young African-American female adult
Authors: Patel Akshar , Kim Alex , Loomis James Grant , Okwara Tracey , Miller Michael 
Published: December 2022

AbstractTrichotillomania refers to repetitive pulling of hair from the body and may be accompanied by trichophagia, the ingesting of extracted hair. It is frequently comorbid with other psychiatric disorders and resulting hair loss can seriously affect quality of life. Trichophagia can lead to trichobezoars, indigestible aggregations of hair in the gastrointestinal tract that can cause pain and bowel obstruction. Descriptions of trichotillomania and trichophagia have generally assumed European hair texture and styling conventions with little attention to Black hair. Here we report the case of a 23-year-old African-American female patient that presented with a small bowel obstruction from ingestion of hair extracted from a hair weave, a popular styling practice and form of hair extension frequently used with women of African descent and various ethnic groups.
Large number system integration aspects: on orbit data and lessons learnt from launching 144 FEEP propulsion systems
Authors: Krejci David , Reissner Alexander 
Published: December 2022

AbstractThis manuscript discusses the on orbit data availability and system integration aspects of the ENPULSION NANO liquid metal FEEP propulsion systems. We present flight data from thrusters on LEO spacecraft, and present and discuss data availability from 142 NANO propulsion systems that were launched in the previous 4 years on 64 different spacecraft, ranging from 3 U Cubesats to > 100 kg platforms. In parallel, new propulsion systems based on FEEP technology have been developed, expanding the thrust and power range and introducing new features, as well as lessons learnt from the large space heritage of the NANO. Two of these new propulsion systems have been launched to space so far. In this work we present telemetry of NANO operation over several hundred hours as well as aggregated on orbit statistical data of the NANO including the thrusting time over all units in space which accumulated to > 3000 h of thrusting. We then discuss challenges encountered and present lessons learnt during on orbit operations, customer AIT support and ground test campaigns conducted at different facilities.
Philosophical Role-Playing in Cicero's Letters to Paetus, 46bc
Authors: McConnell Sean 
Published: December 2022

AbstractIn his letters to Lucius Papirius Paetus from 46bcCicero provides striking reports on his thoughts and activities as he seeks to accommodate himself to the new political realities following Caesar's decisive victory over the republican forces in Africa. In these letters Cicero also engages in a kind of performative role-playing: he casts himself variously as a teacher of oratory to two of Caesar's close associates (Hirtius and Dolabella), as abon vivantimmersed in the Caesarian social scene, and as a man of moral principle who measures himself against the model of the wise man. Philosophical jokes, allusions, and arguments all figure prominently: Cicero is evidently drawing on a rich range of philosophical material to frame his actions and how he should be judged. This paper brings out the full significance of these underlying philosophical frameworks and makes clear the ways in which Cicero exploits the resources of the Greek philosophical tradition in his self-fashioning in the letters to Paetus.
Running in the Family: Inheritance and Family Resemblance in Suetonius’Lives of the Caesars
Authors: Garrett Phoebe 
Published: December 2022

AbstractThe ancestry sections in Suetonius’Lives of the Caesarsdemonstrate the inheritance of character traits down the family line. The effectiveness of this as a rhetorical technique rests on an expectation of inheritance and resemblance along the family line. This study investigates the mechanism of that resemblance from the evidence available in Suetonius’ text—nature or nurture?—and then proposes that since the mechanism appears to be not quite the same as that evidenced in earlier writers, the biographer's model of inheritance and degeneration is part of a conversation about succession to the principate. Part one sets out the patterns of resemblance/difference that appear from the lists of ancestors, part two the evidence for nature and nurture of character traits in Suetonius’Lives, and part three compares the way resemblance works in Suetonius with the way it works in other authors. As modern views on nature and nurture have changed with social and political changes, the final section proposes that the changes over the first century of the principate have to do with the political and social changes in that period. Suetonius’ model of hereditary vice, not hereditary virtue, arises from a disaffection with the system of hereditary succession.
The Date of Eunapius’Vitae Sophistarumand the Establishment of the Martyr Cult in Menouthis
Authors: Vedeshkin Mikhail A. 
Published: December 2022

AbstractThe paper is a contribution to a discussion on the dating of Eunapius’Vitae Sophistarum. Arguments are put forward that Eunapius’ remark on the necrolatry of the monks of Canopus reflects the establishment of a cult of Saints Cyrus and John. Since this event took place when the Church of Alexandria was headed by Cyril, we may consider the beginning of his archbishopric (October 18, 412 CE) as a reliableterminus post quemfor the publication of this text.