bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between loss of cervical lordosis and the degree of cervical disc herniation
Authors: Widyasari Ni Nyoman , Martadiani Elysanti Dwi , Asih Made Widhi , Widiana I Gde Raka , Sitanggang Firman Parulian , Patriawan Putu 
Published: February 2022

Background: Chronic neck pain is a common health problem and is increasingly relevant in health-related quality of life, not only in industrialized countries. The etiology of neck pain is very complex and may be associated with disc herniation, facet joints, muscles, and ligaments that cervical stability will gradually decrease and can cause damage and lead to loss of cervical lordosis. However, studies rarely report the correlation between cervical lordosis and cervical herniation in patients with neck pain. The purpose of this study was to determine the profile of cervical lordosis curves in patients with chronic neck pain and prove the correlation between the degree of cervical disc herniation with loss of cervical lordosis.Method: This study was designed as an analytic study with a retrospective cross-sectional approach. Cervical lordosis curves are measured from mid sagittal cervical MRI while the degree of cervical disc herniation is evaluated using a herniation score. The Spearman correlation test and a simple linear regression test were performed to assess the relationship between loss of cervical lordosis and cervical herniation severity. Multivariate analysis was performed to adjust for the effect of confounding variables.Result: A total of 67 study samples, 64.2% male and 35.8% female, with an average age of 54.7 Â± 12.5. Cervical lordosis angle was found not normal (86.6%), most are in the form of hypolordosis (41.8%) and kyphosis (43.3%). The most herniation was in protrusion stage (47.8%). There was a significant correlation between the loss of the cervical lordosis and the degree of disc herniation (r -0.259, and p-value 0.034), each increase of one cervical disc herniation score affects the angle of the lordosis curve by -1.9 degrees, with a coefficient value of B = -1,914 (95% CI, p = 0.026).Â Conclusion: there is a significant correlation between loss of cervical lordosis and cervical disc herniation (p <0.05).Â
Expression of GLUT-1 and GLUT-3 on spermatogenesis and fertility in rat testis with diabetes mellitus: an experimental study
Authors: Maulana Pongky Alend , Ghinorawa Tanaya , Heriyanto Didik Setyo , Brodjonegoro Sakti Ronggowardhana 
Published: February 2022

Introduction: Diabetes mellitus is a major public health problem worldwide that may cause organ failure and dysfunction such as reproduction dysfunction, including infertility. Glucose metabolism is an important process in spermatogenesis. Glucose Transporters (GLUTs) play an important role in transferring glucose into cells to carry out the sperm capacitation process and maintain sperm motility. Although glucose is needed in spermatogenesis, hyperglycaemic conditions may cause detrimental effects on male fertility. This study was conducted to analyze the impact of hyperglycaemic status in rats on testicular function of spermatogenesis, specifically regarding GLUT-1 and GLUT-3.Methods: This study was an experimental study done in the integrated research and testing laboratory of Universitas Gadjah Mada from June to August 2018. This study used male Wistar rats, randomly divided into three groups as two intervention groups given Streptozotizin (STZ) induction for 4 and 8 weeks and one control group. The minimum sample size in each group was 9. Furthermore, the mRNA expression of GLUT-1 and GLUT-3 genes were assayed by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR).Results: This study showed an increase in GLUT-1 and GLUT-3 expression in rats that experienced hyperglycemia for 4 weeks (p = 0.008 and p = 0.002, respectively). Increased expression of GLUT-1 and GLUT-3 also occurred in rats that experienced hyperglycemia for 8 weeks, but the increase was not statistically significant (p=0.36 and p=0.079).Conclusion: Hyperglycaemia may cause an increase in GLUT-1 and GLUT-3 expression. This expression indicates that GLUT-1 and GLUT-3 are very sensitive to glucose levels changes and may play a role in spermatogenesis changes in patients with diabetes mellitus.
The consistency of visual acuity measurement using PEEK acuity and Snellen-E performed by trained teachers in elementary school students
Authors: Andayani Ari , Saraswati Ni Made Gita , Suryathi Ni Made Ari , Rahayu Ni Kompyang 
Published: February 2022

Background: Visual impairment in children affects growth and development, psychological, social, daily activities, which reduce the quality of life. Children often don't realize that they see "lack of" and do not complain of any difficulty in seeing. Collaboration between medical and non-medical personnel could be developed as a tiered health service team. Teachers as educators could help the health service team through health education and eye screening. The purpose of this study was to find out the consistency of visual acuity measurements by trained teachers using PPEK acuity and Snellen-E.Methods: This study is an analytic cross sectional study conducted on 178 samples in elementary school. Visual acuity was measured by trained teachers using PEEK Acuity and Snellen-E cards and ETDRS by an ophthalmologist. Data analysis using Bland Altman and Rank-Spearman correlation test.Results : Mean difference in visual acuity measurement with PEEK Acuity by trained teacher and ETDRS by ophthalmologist are 0,0028 logMAR (p = 0,543; 95% CI -0,0063 – 0,0119; 95% limit of agreement -0,11766 - 0,12326). Mean difference in visual acuity measurement with Snellen-E by trained teacher and ETDRS by ophthalmologist shows 0,0090 logMAR (p = 0,103; 95% CI -0.0018 – 0.0198; 95% limit of agreement -0.13426 – 0.15225). Mean difference in visual acuity measurement with PEEK Acuity and Snellen-E by trained teacher shows -0,0062 logMAR (p = 0.248; 95% CI -0,0175– 0,0052; 95% limit of agreement -0,15667 – 0,144269).Conclusion: Visual acuity measurement using PEEK Acuity and Snellen-E by trained teachers and ETDRS by an ophthalmologist are consistent and could replace each other.
A case of Nevus of Ota treated with laser picosecond Alexandrite 755 nm: A case-report
Authors: Winaya Ketut Kwartantaya , Setiadji I Made 
Published: February 2022

Background: Nevus of Ota is a well-defined dermal melanocytosis characterized by bilateral multiple small, bluish-brown macules in the area innervated by the first and second branches of the trigeminal nerve. Currently, the therapeutic modalities for this condition are still limited and complete resolution is difficult to achieve.Case Description: A 23-year-old woman complained a brown spot on the right cheek since the patient was born. It looked like the skin but slightly darker than its surroundings. Four years ago the patient had received 6 sessions of QS: Nd-YAG laser therapy, but the spot is still clearly visible. Dermatological status of the orbital, infraorbital, zygomatic, and right buccal regions showed multiple hyperpigmented patches, gray-brown, well-defined, geographically in shape with size 0.2 x 0.3cm – 5 x 7cm. The lesion was unilateral and distributed within the innervation area of the second and third trigeminal nerve. Miravex® skin analysis showed that the average level of melanin was 0.464 with a melanin variation of 45%. Therefore, patient was diagnosed with Nevus of Ota. The proposed treatment was picosecond alexandrite 755nm laser, with a frequency of 2.5 Hz, pulse duration 550-750 ps, spot size 4 mm, and fluence 1.59 J/cm2. A marked improvement was observed after the treatment and after 21 days, a good grade of improvement was reported.Conclusion: Nevus of Ota can effectively treated with 755nm picosecond alexandrite laser therapy and results in a good grade of improvement.
Kematian janin dalam kandungan pada ibu hamil dengan infeksi sifilis laten: laporan kasus
Authors: Lusyana Hani , Damayanti Lina , Walujo Agus 
Published: February 2022

Background: Pregnant women and newborns are a group that is prone to contracting sexually transmitted infections, although they do not directly engage in high-risk sexual behavior. One that has an unexpected impact on pregnant women and newborns is syphilis by the bacterium Treponema pallidum. Transmission of syphilis from mother to fetus is usually worse when the infection in pregnant women is not detected or not appropriately treated early in pregnancy. This case report aims to evaluate fetal death in the womb in pregnant women with latent syphilis infectionCase Presentation: A 19-year-old pregnant woman aged 31-32 weeks diagnosed with late postpartum spontaneous Intrauterine Fetal Death (IUFD) with early latent syphilis. The diagnosis of syphilis was made based on the Veneral Disease Research Laboratory (VDRL) serological test (1:64), Treponema Pallidum Hemagglutination Assay (TPHA) (1:1,280), and without any mucocutaneous complaints. The patient received Benzathine Penicillin G 2.4 million IU single dose intramuscularly. The diagnosis of IUFD was made one day after the administration of therapy and the baby was born with multiple congenital abnormalities.Conclusion: Undiagnosed and adequately treated syphilis in pregnant women can result in perinatal death caused by multiple congenital abnormalities. Latar Belakang: Ibu hamil dan bayi baru lahir merupakan kelompok rawan tertular infeksi menular seksual, walaupun tidak secara langsung berperilaku seksual resiko tinggi. Salah satu yang memiliki dampak kelahiran yang tidak diharapkan pada ibu hamil dan bayi baru lahir adalah Sifilis oleh bakteri Treponema pallidum. Transmisi sifilis dari ibu ke janin biasanya berakibat buruk ketika infeksi pada ibu hamil tidak terdeteksi atau tidak diobati secara benar di awal kehamilan. Laporan kasus ini bertujuan mengevaluasi kematian janin dalam kandungan pada ibu hamil dengan infeksi sifilis latenPresentasi Kasus: Seorang wanita hamil berusia 19 tahun usia kehamilan 31-32 minggu dengan diagnosis akhir postpartum spontan Intrauterine Fetal Death (IUFD) dengan sifilis laten dini. Diagnosis sifilis ditegakkan berdasarkan tes serologis Veneral Disease Research Laboratory (VDRL) (1:64), Treponema Pallidum Hemagglutination Assay (TPHA) (1:1.280), dan tanpa adanya keluhan mukokutaneus. Pasien mendapatkan terapi Benzatin Penisilin G 2.4 juta IU single dose secara intramuskular. Diagnosis IUFD ditegakkan satu hari setelah pemberian terapi dan bayi yang dilahirkan memiliki kelainan kongenital multipel.Kesimpulan: Sifilis pada ibu hamil yang tidak terdiagnosis dan diterapi dengan adekuat dapat mengakibatkan terjadinya kematian perinatal yang disebabkan oleh kelainan kongenital multipel.
Karakteristik pasien kanker kulit non-melanoma di RSUP Sanglah pada periode tahun 2014 - 2018
Authors: Yogiswara I Gusti Agung Ivan , Saputra Herman , Ekawati Ni Putu 
Published: February 2022

Background: Skin cancer is a disease caused by changes in the properties of the constituent skin cells from normal to malignant. There are 3 most common types of skin cancer: Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), and malignant melanoma. This study aims to determine the clinicopathological characteristics of non-melanoma skin cancer patients, especially BCC and SCC, at Sanglah General Hospital, Denpasar, in 2014 – 2018.Methods: This study is a retrospective descriptive study. Clinicopathological data of non-melanoma skin cancer patients were obtained from the histopathological examination archive at the Anatomical Pathology Laboratory of Sanglah General Hospital from 2014 – 2018. Data were analyzed using SPSS version 20 for Windows.Results: During 2014 – 2018, there were 100 patients with non-melanoma skin cancer at Sanglah Hospital. Based on histopathological type, there were 39 cases (39.0%) of BCC and 61 cases (61.0%) of SCC. BCC was predominant in the age group above 70 years (33.33%) and the highest type of SCC in the age group 50-59 years (32.79%). Based on gender, BCC is more frequent in women by 53.85% and SCC is more frequent in men by 54.10%.Conclusion: The highest non-melanoma skin cancer cases were SCC with age more than 50 years and were more commonly found in men. Latar Belakang: Kanker kulit adalah salah satu penyakit yang diakibatkan oleh berubahnya sifat-sifat penyusun sel kulit yang awalnya normal menjadi ganas. Terdapat 3 jenis kanker kulit yang tersering, yaitu Karsinoma Sel Basal (KSB), Karsinoma Sel Skuamosa (KSS), dan melanoma maligna. Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi pasien kanker kulit non-melanoma khususnya karsinoma sel basal dan karsinoma sel skuamosa di RSUP Sanglah Denpasar pada periode tahun 2014 – 2018.Metode: Penelitian ini adalah penelitian deskriptif retrospektif. Data klinikopatologi pasien kanker kulit non-melanoma diperoleh dari arsip pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar tahun 2014 – 2018. Data dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Selama periode tahun 2014 – 2018 terdapat 100 pasien kanker kulit non-melanoma. Berdasarkan tipe histopatologi, terdapat 39 kasus (39,00%) KSB dan 61 kasus (61,00%) KSS. KSB ditemukan terbanyak pada kelompok usia diatas 70 tahun (33,33%) dan tipe KSS terbanyak pada kelompok usia 50-59 tahun (32,79%). Berdasarkan jenis kelamin, KSB lebih banyak pada perempuan sebesar 53,85% dan KSS lebih banyak pada laki – laki sebesar 54,10%.Kesimpulan: Kasus kanker kulit non-melanoma tertinggi adalah KSS dengan usia lebih dari 50 tahun dan lebih banyak ditemukan pada laki – laki.
Acute Decompensated Heart Failure (ADHF) with aortic dissection Stanford A in middle aged man: a case report
Authors: Umam Anbiya Khairul , Widiarta Ida Bagus Wisnu , Intizam Marwa Humaira , Prasetyo Aizar Vesa , Yasa Ketut Putu 
Published: February 2022

Background: Heart failure is a clinical syndrome with shortness of breath, fluid retention, and the heart's structural and functional disorder. Each year, there were 7,2 cases every 1000 people on male and 4,7 cases every 1000 people on the female. Aortic dissection is an emergency disease in which the symptoms are similar to ischemic heart disease, that 38% of patients got misdiagnosed on the first evaluations. Because of the clinical course of heart failure and misdiagnosed aortic dissection that frequently happened, authors are interested in making a case report with both conditions.Case report: A male patient, 39 years old, complained of shortness of breath and epigastrium pain. The patient was diagnosed with Acute Decompensated Heart Failure (ADHF) profile B with emergency hypertension and suspected aortic dissection based on history and physical examination. The patient was also diagnosed with acute kidney injury stage 1. CT angiography showed widening of the aorta ascending until arcus aorta with a Stanford type A aortic dissection diagnosis.Conclusion: The condition of aortic dissection can coincide with acute heart failure. Therefore, a clinician must be aware of the emergency of dissection and know the initial symptoms of dissection. The typical clinical symptoms of dissection lead us to perform imaging studies that ultimately lead to a thoracoabdominal CTA to diagnose the dissection.
Efektivitas terapi inhibitor janus kinase pada vitiligo: tinjauan pustaka
Authors: Gunawan Harry , Rakhmawati Flora Anisah 
Published: February 2022

Background: Vitiligo is an autoimmune disease that causes progressive skin melanocyte destruction, clinically seen as asymptomatic depigmentation macule and poliosis. CD8+ T cell is the primary effector of melanocyte destruction, and the activities of CD8+ T cell are driven by interferon-? (IFN-?). The current vitiligo treatment options are often not satisfied with many limitations and a high recurrence rate. Janus Kinase (JAK) inhibitor is one of the emerging vitiligo therapies which has a more specific target with a direct effect on CD8+ T cell cytotoxicity and IFN-?.Methods: In writing this article, the literature review method was used, and sources consist of relevant journals obtained through online search engines.Result: Several studies show that repigmentation in the facial area increases between 51-92%. Repigmentation occurs better in areas exposed to sunlight or a combination of phototherapy because repigmentation in vitiligo lesions requires suppression of the autoimmune process and melanocyte regeneration.Conclusion: Many studies showed the results of vitiligo therapy using JAK inhibitors were very promising and safe. The vitiligo therapy using JAK inhibitor showed higher efficacy on the facial area and combined with ultraviolet exposure. Latar belakang: Vitiligo merupakan penyakit autoimun yang menyebabkan destruksi melanosit secara progresif pada kulit, menimbulkan makula depigmentasi asimtomatik dan poliosis. Sel T CD8+ merupakan efektor primer yang menyebabkan kematian melanosit dan aktivitasnya ditingkatkan oleh interferon-? (IFN-?). Pilihan terapi vitiligo saat ini seringkali tidak memuaskan, memiliki keterbatasan, dan memiliki tingkat kekambuhan yang tinggi. Inhibitor Janus Kinase (JAK) merupakan salah satu terapi baru vitiligo yang memiliki target lebih spesifik dengan efek langsung terhadap sitotoksisitas sel T CD8+ dan IFN-?.Metode: Dalam penulisan artikel ini digunakan metode tinjauan pustaka dengan bersumber pada artikel relevan yang didapatkan melalui pencarian secara daring. Hasil: Beberapa studi menunjukkan adanya repigmentasi pada area wajah meningkat antara 51-92%. Repigmentasi terjadi lebih baik pada area terpapar sinar matahari atau kombinasi fototerapi disebabkan karena repigmentasi pada lesi vitiligo membutuhkan supresi dari proses autoimun dan regenerasi melanosit.Simpulan: Berbagai studi menunjukkan hasil terapi inhibitor JAK terhadap vitiligo sangat menjanjikan dan cukup aman. Terapi inhibitor JAK menunjukkan efektivitas lebih tinggi pada area wajah dan dengan kombinasi paparan ultraviolet.
Taunaki Puna Reo: Kaiako Considerations of Mana and Kaitiakitanga
Authors: Rameka Lesley , Soutar Brenda Eva , Paki Vanessa Anne , Clayton Leanne 
Published: February 2022

Wellbeing is fundamental to an individual’s ability to function and live well. Māori have some of the worst wellbeing statistics in New Zealand (Chalmers & Williams, 2018). From a Māori worldview, mana (power, authority) and kaitiakitanga (guardianship) encapsulate the critical relationships necessary to Māori understandings of wellbeing. These relationships reflect the interconnectedness and interdependence of humans with the people, places and things in their worlds, as well as the responsibilities associated with these relationships.
This article discusses findings from phase two of a Teaching and Learning Research Initiative funded project Te Whakapūmautia te mana: Enhancing Mana Through Kaitiakitanga (2020–2021), and outlines implications for early childhood education (ECE) from the findings. The project aimed to explore the ways that ECE accords mokopuna (children) opportunities to recognise mana and understand ways to accrue and attain mana through being kaitiaki (guardians) of themselves, others and their environment, thereby contributing to a collective sense of wellbeing. Phase two of the research focused on kaiako (teachers’) understandings of mana and kaitiakitanga and how they are currently reflected in Māori medium ECE services.
Utility of radial flaps for defect repair after surgical excision of head and neck tumors
Authors: Kropotov M. A. , Sobolevsky V. A. , Yakovleva L. P. , Khodos A. V. , Saprina O. A. , Safarov D. A. 
Published: February 2022

Introduction. Surgery at the first stage has always been the gold-standard treatment for locally advanced head cancer of almost all locations. Such patients often have significant postoperative defects that cause serious functional and aesthetic disorders. This requires simultaneous defect repair. The technique of defect repair should be chosen carefully with the consideration of its benefits and potential consequences.Objective – to evaluate the efficacy of revascularized radial flaps for defect repair after combination extensive surgical excisions of head and neck tumors.Materials and methods. This study included 67 patients with head and neck cancers of different locations who had undergone surgical tumor excision followed by defect repair using a radial flap.Results. All patients had their defects repaired using radial autologous grafts. Since this study included primarily patients with oral and oropharyngeal tumors (53 patients), we also analyzed the survival in this cohort. patients were followed-up for 2 to 7 years. fourteen patients (26.4 %) developed progressive disease during this time, including 8 individuals with recurrent primary tumor and 6 individuals with regional metastases. The mean time to nasoesophageal probe removal and restored swallowing was 12.2 days; mean length of hospital stay was 13.5 days.Conclusion. Thus, radial flap is a reliable and multifunctional material that can be used to repair complex and combination defects in patients with head and neck tumors. In some cases, it is the method of choice, since it helps to achieve satisfactory quality of life. Repair of tongue defects with radial flaps ensures good functional results.
The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity
Authors: Sekretnaya A. O. , Zaderenko I. A. , Ivanov S. Yu. , Alieva S. B. , Dymnikov A. B. , Kaledin R. R. , Alsayed Hachem H. 
Published: February 2022

Introduction. Oral mucositis is one of the earliest and most frequent complications of radiation therapy or chemotherapy in patients diagnosed with oropharyngeal cancer. Because of this pathology, therapeutic interventions are most often used, thereby poor treatment is considered an etiological factor of oral mucositis. Now, this issue is being actively studied in the world, but a unified algorithm for treatment and prevention of oral mucositis has not been formed.The study objective – is to evaluate the effect of titanium glycerosolvate aquacomplex in reducing the intensity of radiation induced reactions and reducing the frequency of interruptions.Materials and methods. 52 patients diagnosed with oropharyngeal cancer were included in this study, treated with radiotherapy or chemotherapy. For prophylaxis of severe stages of oral mucositis, 32 patients underwent standard symptomatic therapy (group 1, control group); 20 patients took titanium glycerosolvate aquacomplex in accordance with symptomatic therapy (group 2).Results. In the group 1 only 61.7 % of patients completed treatment. In the group 2 80 % of patients completely underwent antitumor therapy. At the same time, they developed oral mucositis of the I–II degree. Also, in the group of the studied drug, in 100 % of cases, therapy was performed without interruptions.Conclusion. Using titanium glycerosolvate aquacomplex for the prophylaxis of severe stages of oral mucositis during radiotherapy or chemotherapy of oropharyngeal cancer is effective and safe. It is also convenient from the medical and economic side, thanks to the ability to use it on an outpatient basis.