bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospect for Designing Wearable Devices for Children’s Asthma Attack Detection Based on Internet of Things and Cloud Computing
Authors: Wicaksono A. I. , Sahtyawan R , Hariyadi D , Nastiti F E 
Published: March 2022

Abstract
Indonesia’s geographical location as an archipelago makes this country has a humid tropical climate. This climate will affect asthmatics. Asthma attacks a patient suddenly, this is very dangerous especially if the patient is a child. Before attacking usually, asthma will react to the body with the characteristics of changes in breathing frequency, pulse frequency, mild, severe, even to the point of stopping breathing. Asthma attacks will be very dangerous for children who are not under the supervision of their parents (being in school for example). It can be imagined if asthma with severe clusters aims. The purpose of this study is to propose the design of wearable-type devices used in children at home to facilitate monitoring of asthma attacks through the internet network.
Enhancing the flexural load capacity of the reinforced concrete beams using Dramix 3D 80/60 BG steel fibres
Authors: Noorhidana V A , Isneini M , Putra A M 
Published: March 2022

Abstract
The purpose of this study was to investigate the effect of adding Dramix 3D 80/60 BG steel fibres to the reinforced concrete beams experimentally. The main specimens were 6 reinforced concrete beams (dimension of 150 x 180 x 1700 mm) with a variety of the flexural reinforcement (i.e. 2D6, 2D10 and 3D10) and the fibre volume fraction (i.e. 0%, 0.5%, 1% and 1.5%). The concrete compressive strength was 25 MPa, no superplasticizer was added in the concrete mix. The test set-up of the beam specimen is, the beam was simply supports at the distance of 1500mm, 2 concentrated loads gradually were applied until it collapses. During applying the loads, measurements were taken including the deflection in the mid-span of the beam, the crack propagation and crack width. The results showed that the increase of fibre content will increase the load capacity and stiffness without reducing the ductility of the reinforced concrete beams. The steel fibre volume fraction of 1% is the maximum content that can be used without using superplasticizer to maintain the workability of the fresh concrete. The addition of 0.5% steel fibre provides a similar flexural performance to the addition of one D10 (flexural reinforcement) in a reinforced concrete beam.
Fully printed and flexible multi-material electrochemical aptasensor platform enabled by selective graphene biofunctionalization
Authors: Wallace Shay Goff , Brothers Michael C , Brooks Zachary E , Rangnekar Sonal V , Lam David , Lawrence Michael J St , Rojas William A Gaviria , Putz Karl W , Kim Steve S , Hersam Mark C 
Published: March 2022

AbstractThe demand for flexible biochemical sensors has increased with advances in computational functionality and wireless communication. Advances in materials science and biochemistry have enabled the development and fabrication of biosensors for selective detection of biological analytes leveraging ink-printed technologies, including in flexible form-factors. However, despite these advances, minimal effort has been devoted to translating the multi-material, three-electrode electrochemical cell, which is widely regarded as the standard for laboratory-scale studies, into a flexible form-factor for use in immunosensors, especially in a manner that is compatible with rapid and scalable additive manufacturing. Here, we report a fully printed and flexible electrochemical non-enzymatic immunosensor platform that integrates four chemically compatible inks and a non-covalent, two-step biofunctionalization scheme. The robustness of the platform is demonstrated using a model aptasensor that enables lysozyme detection using both electrochemical impedance spectroscopy and square wave voltammetry. The flexible, fully ink-printed aptasensor shows competitive performance to commercially available rod/disc electrodes in a bath cell. Overall, this work establishes a methodology for high-throughput fabrication of robust, flexible, multi-material, three-electrode immunosensors that can be generalized to a range of biosensor applications.
Hardy spaces meet harmonic weights
Authors: Preisner Marcin , Sikora Adam , Yan Lixin 
Published: March 2022

We investigate the Hardy space

H
L
1

H^1_L

associated with a self-adjoint operator

L
L

defined in a general setting by Hofmann, Lu, Mitrea, Mitrea, and Yan [Mem. Amer. Math. Soc. 214 (2011), pp. vi+78]. We assume that there exists an

L
L

-harmonic non-negative function

h
h

such that the semigroup

exp
⁡
(
−
t
L
)

\exp (-tL)

, after applying the Doob transform related to

h
h

, satisfies the upper and lower Gaussian estimates. Under this assumption we describe an illuminating characterisation of the Hardy space

H
L
1

H^1_L

in terms of a simple atomic decomposition associated with the

L
L

-harmonic function

h
h

. Our approach also yields a natural characterisation of the

B
M
O

BMO

-type space corresponding to the operator

L
L

and dual to

H
L
1

H^1_L

in the same circumstances.

The applications include surprisingly wide range of operators, such as: Laplace operators with Dirichlet boundary conditions on some domains in

R

n

{\mathbb {R}^n}

, Schrödinger operators with certain potentials, and Bessel operators.
The Role of Comparative Law in the Analysis of Judicial Behavior
Authors: Epstein Lee , Šadl Urška , Weinshall Keren 
Published: March 2022

Abstract
Comparing and contextualizing what judges say about the law is the job of comparative legal analysis. Studying internal and external forces that explain the judges’ choices and their societal effects is the core domain of the comparative study of judicial behavior. Although walls may seem to separate these two projects in terms of their theoretical approaches and methods, the barriers—and the obstacles—are more imagined than real.
In an effort to highlight the complementarities between the two areas of studies—and issue what amounts to a standing invitation to comparative lawyers to contribute their specialized knowledge to the analysis of judging—the Article turns first to the aspirations of the study of judicial behavior. Next, we introduce six core theories of judging, along with the methods and data used to assess their implications. Along the way, we flag opportunities for future research, emphasizing potential collaborations among all scholars with an interest in comparative legal analysis.
Determining the applicable law to the arbitration agreement in the absence of a choice of law clause under Hong Kong Law: a call for renewed internationalism
Authors: Nordlund Filip 
Published: March 2022

Abstract
The courts of Hong Kong have determined the governing law of the underlying contract to indicate an express, implied and no choice of the law applicable to the arbitration agreement. In determining the applicable law, the courts made no references to the New York Convention despite the fact that the provisions under Hong Kong arbitration law pursuant to which the foregoing determinations were made are based on provisions in the New York Convention and ought to be applied in conformity with the same. This article argues that the courts of Hong Kong ought to adopt the New York Convention’s conflict of laws rules in Article V(1)(a) to determine the governing law of arbitration agreements in pre- and post-award proceedings in order to enhance the alignment of Hong Kong law with the international body of arbitration law.
Mysteries and unsolved problems of mammalian fertilization and related topics
Authors: Yanagimachi Ryuzo 
Published: March 2022

AbstractMammalian fertilization is a fascinating process that leads to the formation of a new individual. Eggs and sperm are complex cells that must meet at the appropriate time and position within the female reproductive tract for successful fertilization. I have been studying various aspects of mammalian fertilization over 60 years. In this review, I discuss many different aspects of mammalian fertilization, some of my laboratory’s contribution to the field, and discuss enigmas and mysteries that remain to be solved.
Typical and disrupted brain circuitry for conscious awareness in full-term and preterm infants
Authors: Hu Huiqing , Cusack Rhodri , Naci Lorina 
Published: March 2022

AbstractOne of the great frontiers of consciousness science is understanding how early consciousness arises in the development of the human infant. The reciprocal relationship between the default mode network and fronto-parietal networks—the dorsal attention and executive control network—is thought to facilitate integration of information across the brain and its availability for a wide set of conscious mental operations. It remains unknown whether the brain mechanism of conscious awareness is instantiated in infants from birth. To address this gap, we investigated the development of the default mode and fronto-parietal networks and of their reciprocal relationship in neonates. To understand the effect of early neonate age on these networks, we also assessed neonates born prematurely or before term-equivalent age. We used the Developing Human Connectome Project, a unique Open Science dataset which provides a large sample of neonatal functional MRI data with high temporal and spatial resolution. Resting state functional MRI data for full-term neonates (n = 282, age 41.2 weeks ± 12 days) and preterm neonates scanned at term-equivalent age (n = 73, 40.9 weeks ± 14.5 days), or before term-equivalent age (n = 73, 34.6 weeks ± 13.4 days), were obtained from the Developing Human Connectome Project, and for a reference adult group (n = 176, 22–36 years), from the Human Connectome Project. For the first time, we show that the reciprocal relationship between the default mode and dorsal attention network was present at full-term birth or term-equivalent age. Although different from the adult networks, the default mode, dorsal attention and executive control networks were present as distinct networks at full-term birth or term-equivalent age, but premature birth was associated with network disruption. By contrast, neonates before term-equivalent age showed dramatic underdevelopment of high-order networks. Only the dorsal attention network was present as a distinct network and the reciprocal network relationship was not yet formed. Our results suggest that, at full-term birth or by term-equivalent age, infants possess key features of the neural circuitry that enables integration of information across diverse sensory and high-order functional modules, giving rise to conscious awareness. Conversely, they suggest that this brain infrastructure is not present before infants reach term-equivalent age. These findings improve understanding of the ontogeny of high-order network dynamics that support conscious awareness and of their disruption by premature birth.
Social approach and avoidance in language: N400-like ERP negativity indexes congruency and theta rhythms the conflict
Authors: Marrero Hipólito , Yagual Sara Nila , Lemus Alejandro , García-Marco Enrique , Díaz Jose Miguel , Gámez Elena , Urrutia Mabel , Beltrán David 
Published: March 2022

AbstractMotivational congruency has been examined using tasks where participants perform approach or avoidance movements towards socially positive or negative faces. Language is tightly intertwined with interpersonal cognition. Thus, similar situations could be represented by means of language in interpersonal contexts: adjectives furnish valence to people (e.g. someone is cordial or arrogant), and attitudinal verbs define direction to relationship-actions: approach–avoidance (e.g. accept vs. reject). In an Electroencephalography (EEG) study, 40 participants were presented with sentences where a character was valenced (e.g. “Arthur is cordial/arrogant”) before being the target of a relationship-actions (“Grisela welcomed/ignored Arthur at the party”). We analyzed both Event-related potential (ERP) amplitude and time–frequency power in response to the attitudinal verb. For ERP amplitudes, we found a significant cluster between 280 and 370 ms, covering part of the development of a N400-like ERP component. This cluster reflects an interaction driven by congruency between motivational direction and target valence. Likewise, time–frequency power analysis revealed an enhancement of theta rhythms under incongruent conditions, most likely indexing conflict processing. Results support that relationship-actions are represented as approach and avoidance and thus involve conflict processing and resolution of incongruent situations. Implications for the interweaving of affective language and social cognition within Embodiment Simulation Theory are discussed.
Temporal changes in the histology of microscopic colitis
Authors: Sonnenberg Amnon , Genta Robert M 
Published: March 2022

Abstract

Background
In a subgroup of patients with microscopic colitis [MC], its histopathology changed from lymphocytic [LC] to collagenous colitis [CC] and vice versa. Previous studies have also observed histopathological transitions between MC and inflammatory bowel disease [IBD].

Aims
The aim of the present study was to analyse the prevalence of such transitions in a large population of MC patients.

Methods
The Inform Diagnostics database is an electronic repository of histopathology records of patients distributed throughout the USA. In a cross-sectional study, we analysed the prevalence of changes in MC histology. Each prevalence was expressed as the rate per 100 MC patients with its 95% Poisson confidence interval.

Results
In a total population of 29 307 MC patients, our cross-sectional study focused on a subgroup of 4363 patients who underwent two or more consecutive colonoscopies between December 2008 and March 2020. Overall, 1.6% [95% CI 1.2–2.0%] of patients changed their MC phenotype from LC to CC, and 0.5% [0.3–0.7%] from CC to LC. Of 4363 MC patients, 414 [9.5%] were also diagnosed with IBD. In 2.9% [2.4–3.5%], MC and IBD were diagnosed as synchronous mucosal lesions. In 2.1% [1.7–2.6%], MC changed to IBD, and in 4.5% [3.9–5.2%] IBD changed to MC.

Conclusions
The analysis confirmed the synchronous occurrence of MC and IBD and transitions between the two diagnoses. In patients who fail therapy for either one of the two diseases, the gastroenterologist should search for changes in the underlying phenotype as a possible explanation.
Etp1 confers arsenite resistance by affecting ACR3 expression
Authors: Romero Antonia M , Maciaszczyk-Dziubinska Ewa , Mombeinipour Mandana , Lorentzon Emma , Aspholm Emelie , Wysocki Robert , Tamás Markus J 
Published: March 2022

Abstract
In a high-throughput yeast two-hybrid screen of predicted coiled-coil motif interactions in the Saccharomyces cerevisiae proteome, the protein Etp1 was found to interact with the yeast AP-1-like transcription factors Yap8, Yap1 and Yap6. Yap8 plays a crucial role during arsenic stress since it regulates expression of the resistance genes ACR2 and ACR3. The function of Etp1 is not well understood but the protein has been implicated in transcription and protein turnover during ethanol stress, and the etp1∆ mutant is sensitive to ethanol. In this current study, we investigated whether Etp1 is implicated in Yap8-dependent functions. We show that Etp1 is required for optimal growth in the presence of trivalent arsenite and for optimal expression of the arsenite export protein encoded by ACR3. Since Yap8 is the only known transcription factor that regulates ACR3 expression, we investigated whether Etp1 regulates Yap8. Yap8 ubiquitination, stability, nuclear localization and ACR3 promoter association were unaffected in etp1∆ cells, indicating that Etp1 affects ACR3 expression independently of Yap8. Thus, Etp1 impacts gene expression under arsenic and other stress conditions but the mechanistic details remain to be elucidated.
Conducting Empirical Research With Older Migrants: Methodological and Ethical Issues
Authors: Bilecen Başak , Fokkema Tineke 
Published: March 2022

Abstract
This special section brings together a set of four articles containing novel quantitative and qualitative research on older migrants in Europe. Detailed reporting and reflection is presented on fieldwork decisions and how certain challenges were tackled, and their implications. This introductory article aims to lay the groundwork for a better understanding and awareness of methodological and ethical challenges researchers face when designing and conducting empirical studies involving older migrants. Highlighted are the main methodological issues and ethical dilemmas we observe in studying older migrants, which can serve as a wake-up call for researchers to be more critical throughout the process. We end with a plea for more collaboration between researchers in the field of older migrants, by sharing their data despite potential methodological and ethical problems.
Recombinant norovirus capsid protein VP1 (GII.4) expressed in H5 insect cells exhibits post-translational modifications with potential impact on lectin activity and vaccine design
Authors: Hanisch Franz-Georg 
Published: March 2022

Abstract
Although surface proteins of most enveloped viruses are glycosylated, among non-enveloped viruses only few express glycoproteins in their capsid as infective virions. Noroviruses belong to the latter group and are known to express one major capsid protein (VP1) that lacks genuine glycosylation. In the context of vaccine development based on virus-like particles (VLPs) and in searches for food additives offering potential prophylactic or therapeutic applications an increasing number of reports refers to the use of VLPs that were produced as secretory products in insect cells. We asked the question whether recombinant VLPs (GII.4 Sydney, 2012) produced via the baculovirus vector in H5 insect cells may be glycosylated in the protruding domains that are involved in receptor binding and immune reactivity. Mass spectrometric analysis of tryptic VP1 peptides prior to and after beta-elimination Michael addition in 70% ethylamine revealed Thr238, and Ser519 in the P1 domain, and Thr350, Thr369, Thr371, and Thr381 in the P2 domain as modified. Thr65, Ser67, and Thr350 were revealed by liquid chromatography-mass spectrometry to carry HexNAc or Hex-HexNAc modifications, respectively. Monosaccharide analysis by gas chromatography–mass spectrometry confirmed the presence of GlcNAc on VLP protein, whereas immunoassays with lectins and antibodies demonstrated O-linked GlcNAc on VP1 protein. Post-translational modifications of virus capsid proteins may contribute to a modulation of immunodominant surface epitopes and need to be considered in anti-norovirus vaccine design. Some modifications are located near amino acid side chains involved in the binding of blood group active sugar receptors.
Poland and Hungary’s EU membership: On not confronting authoritarian governments
Authors: De Búrca Gráinne 
Published: March 2022

Abstract
This Reflection considers why Poland’s and Hungary’s membership of the European Union has remained in many ways unaffected by widespread, serious, and documented actions on the part of those two governments which have gravely weakened the rule of law, democracy, and human rights. The Reflection does not argue for expulsion of these states, but investigates why it is that the European Union’s political institutions and actors (rather than its supranational bodies) have not been willing to confront Poland and Hungary more robustly. The willingness of EU actors to overlook growing authoritarianism in Poland since the Russian invasion of Ukraine highlights these concerns even more starkly.
Trajectories: a framework for detecting temporal clinical event sequences from health data standardized to the Observational Medical Outcomes Partnership (OMOP) Common Data Model
Authors: Künnapuu Kadri , Ioannou Solomon , Ligi Kadri , Kolde Raivo , Laur Sven , Vilo Jaak , Rijnbeek Peter R , Reisberg Sulev 
Published: March 2022

Abstract

Objective
To develop a framework for identifying temporal clinical event trajectories from Observational Medical Outcomes Partnership-formatted observational healthcare data.

Materials and Methods
A 4-step framework based on significant temporal event pair detection is described and implemented as an open-source R package. It is used on a population-based Estonian dataset to first replicate a large Danish population-based study and second, to conduct a disease trajectory detection study for type 2 diabetes patients in the Estonian and Dutch databases as an example.

Results
As a proof of concept, we apply the methods in the Estonian database and provide a detailed breakdown of our findings. All Estonian population-based event pairs are shown. We compare the event pairs identified from Estonia to Danish and Dutch data and discuss the causes of the differences. The overlap in the results was only 2.4%, which highlights the need for running similar studies in different populations.

Conclusions
For the first time, there is a complete software package for detecting disease trajectories in health data.
Synthetic Mammography: Review of Benefits and Drawbacks in Clinical Use
Authors: Chikarmane Sona 
Published: March 2022

Abstract
Digital breast tomosynthesis (DBT) has been widely adopted as a breast cancer screening tool, demonstrating decreased recall rates and other improved screening performance metrics when compared to digital mammography (DM) alone. Drawbacks of DBT when added to 2D DM include the increased radiation dose and longer examination time. Synthetic mammography (SM), a 2D reconstruction from the tomosynthesis slices, has been introduced to eliminate the need for a separate acquisition of 2D DM. Data show that the replacement of 2D DM by SM, when used with DBT, maintains the benefits of DBT, such as decreased recall rates, improved cancer detection rates, and similar positive predictive values. Key differences between SM and 2D DM include how the image is acquired, assessment of breast density, and visualization of mammographic findings, such as calcifications. Although SM is approved by the Food and Drug Administration and has been shown to be non-inferior when used with DBT, concerns surrounding SM include image quality and artifacts. The purpose of this review article is to review the benefits, drawbacks, and screening performance metrics of SM versus DBT.
Examination of Nocturnal Oviposition by Chrysomya putoria (Diptera: Calliphoridae) in Brazil
Authors: Carneiro L T , Azevedo W T A , Aguiar V M , Couri M S 
Published: March 2022

Abstract
This is the first study in Brazil that monitored the nocturnal oviposition behavior of Chrysomya putoria, a species of forensic importance, in order to verify if individuals of this species oviposit at night. Groups of 10 flies (5 male and 5 female) distributed in ten cages were kept in a fume hood and submitted to total darkness or exposed to artificial light for eleven consecutive hours through four experimental conditions in the laboratory. Two verifications were made to see if the females oviposited in the offered substrate of about 20 g of chicken gizzard per cage. Verification 1 occurred at 09:00 pm in the evening experiments and at 09:00 am in the daytime experiments. Verification 2 occurred at 05:00 am in the night experiments and at 05:00 pm in the daytime experiments. Each experiment lasted 5 d. C. putoria laid eggs at night (with or without light) and the quantity of eggs was significantly similar to those produced during the day under natural light or in total darkness. Only the amount of eggs produced during the day in the absence of light was considerably greater than in the typical daytime period. The females oviposited in greater quantity in the nights when the average temperature was between 23 and 24.8°C and relative humidity above 81%. Ovipositions only occurred at temperatures above 21°C and humidity above 56% during the day. Finally, it is necessary that more evaluations on the effect of variables on blowfly behavior are performed to better understand nocturnal oviposition.