bluuebunny/crossref_metadata_2025_split huggingface dataset:
Junction‐Enhanced Polarization Sensitivity in Self‐Powered Near‐Infrared Photodetectors Based on Sb2Se3 Microbelt/n‐GaN Heterojunction
Authors: Wan Peng , Jiang Mingming , Wei Yun , Xu Tong , Liu Yang , Xia Sihao , Su Longxing , Shi Daning , Fang Xiaosheng , Kan Caixia 
Published: November 2022

AbstractPolarization‐sensitive photodetectors (PDs) based on anisotropic materials spark considerable interest for their potential applications in security surveillance, optical switches, and remote sensing. However, high‐thickness or bulk anisotropic materials generally exhibit low polarization sensitivity, hindering their practical applications in polarization photodetection. Herein, a near‐infrared (NIR) PD based on a p‐type Sb2Se3 microbelt (MB)/n‐GaN heterojunction is proposed. The Sb2Se3 MB/GaN PD effectively combines the anisotropy of the Sb2Se3 MB with the heterogeneous integration. The PD presents self‐powered detection properties with a responsivity over 12 mA W−1, a specific detectivity exceeding 5 × 1010 Jones, and a response speed (the rising/decaying times ≈74 ms/75 ms) under NIR illumination. More importantly, the heterojunction‐based PD has a higher anisotropy ratio of 1.37, which is 1.3 times amplified as compared to the vertical photoconductive‐type PDs (the anisotropy ratio of 1.06). The p‐n junction's effect on carrier generation and recombination causes the increased polarization sensitivity of Sb2Se3 MB/GaN PDs, as confirmed by finite element method analysis. This work not only offers a deeper insight into polarization sensitivity regulated by junction or interface but also provides a practical method for developing high‐sensitivity polarization detectors based on high‐thickness or bulk anisotropic materials.
“What I wish I had known before starting my PhD”
Authors: Wiebach Vincent 
Published: November 2022

AbstractAs a rather recent PhD graduate and still an “early career researcher”, the author wondered what to write about that would be interesting for a young scientist. The answer came while overhearing students in the break room stating, “I wish I had known all that before starting my PhD that would have made everything easier!” – An experience many researchers are very familiar with. From simple tricks for laboratory work to choosing the right software or planning the next career steps, this was a reoccurring theme during the career of the author, who will try to give a short personal overview for young researchers, especially in the analytics and/or natural products field. These topics and lists represent a personal opinion and are neither meant to be all‐encompassing nor of course might differ from the experiences of other researchers.
Burkholderia gut symbiont induces insect host fecundity by modulating Kr‐h1 gene expression
Authors: Lee Junbeom , Lee Dae‐Weon 
Published: November 2022

AbstractFull‐length cDNAs of the Broad‐Complex (BR‐C) from Riptortus pedestris were cloned. Moreover, Kr‐h1 and BR‐C expression levels in apo‐symbiotic and symbiotic host insects were compared to verify whether they are modulated by Burkholderia gut symbionts. Interestingly, Kr‐h1 expression level was significantly increased in symbiotic females. To determine how Kr‐h1 affects fecundity in insects, the biosynthesis of two reproduction‐associated proteins, hexamerin‐α and vitellogenin, was investigated in R. pedestris females. Hexamerin‐α and vitellogenin expression at the transcriptional and translational levels decreased in Kr‐h1‐suppressed symbiotic females, subsequently reduced egg production. These results suggest that Burkholderia gut symbiont modulates Kr‐h1 expression to enhance ovarian development and egg production of R. pedestris by increasing the biosynthesis of the two proteins.
Impaired Efferocytosis by Synovial Macrophages in Patients With Knee Osteoarthritis
Authors: Del Sordo Luigi , Blackler Garth B. , Philpott Holly T. , Riviere Jared , Gunaratnam Lakshman , Heit Bryan , Appleton C. Thomas 
Published: November 2022

ObjectiveOsteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the need to clear apoptotic cells from tissues, including the synovium. We undertook this study to assess the burden of apoptotic cells in synovial tissue in patients with late‐stage knee OA and to investigate whether OA impairs the macrophage‐mediated clearance of apoptotic cells via efferocytosis.MethodsSynovial tissue was collected from individuals with healthy knees and patients with late‐stage knee OA during arthroplasty. Synovial apoptotic cell burden was assessed by immunofluorescence for cleaved caspase 3. Efferocytosis of apoptotic Jurkat cells by CD14+ synovial tissue macrophages and peripheral blood–derived macrophages was quantified using immunofluorescence microscopy. Effects of OA on macrophage‐mediated efferocytosis were modeled by stimulating blood‐derived macrophages with synovial fluid collected from individuals with healthy knees and patients with early‐ or late‐stage knee OA.ResultsPatients with late‐stage knee OA had more apoptotic synovial cells compared to healthy individuals. There was a marked reduction in the fraction of synovial tissue macrophages engaging in efferocytosis and the quantity of material efferocytosed by individual macrophages in OA patients. Blood‐derived macrophages exposed to synovial fluid from patients with knee OA recapitulated the defective efferocytosis, with the greatest effect from patients with early‐stage knee OA and higher disease activity (pain and inflammation).ConclusionApoptotic cells accumulate in the synovium of patients with late‐stage knee OA. Our results suggest that OA impairs critical homeostatic functions of synovial macrophages, leading to accumulation of apoptotic cells.image
The therapeutic effect of N‐acetylcysteine as an add‐on to methadone maintenance therapy medication in outpatients with substance use disorders: A randomized, double‐blind, placebo‐controlled clinical trial
Authors: Padoei Fateme , Mamsharifi Peyman , Hazegh Pooya , Boroumand Homa , Ostadmohammady Fatemeh , Abbaszadeh‐Mashkani Samira , Banafshe Hamid Reza , Matini Amir Hassan , Ghaderi Amir , Dehkohneh Somayeh Ghadami 
Published: November 2022

AbstractObjectivePatients with substance use disorders (SUD) under methadone maintenance therapy (MMT) are susceptible to a number of complications (psychological and metabolic disorders). Evidence studies have shown the roles of the glutamatergic system in addiction. N‐Acetylcysteine (NAC) enhances extracellular glutamate, and is effective in the treatment of neuropsychiatric disorders. We assessed oral NAC as an add‐on to MMT medication for the treatment of SUD.MethodsIn the current randomized, double‐blind, placebo‐controlled clinical trial, outpatients with SUD under MMT who were 18–60 years old received 2400 mg/day NAC (n = 30) or placebo (n = 30) for 12 weeks. Psychological status and metabolic biomarkers were assessed at baseline and the end of the trial.ResultsCompared with the placebo group, NAC treatment resulted in a significant improvement in depression score (β −2.36; 95% CI, −3.97, −0.76; p = .005), and anxiety score (β −1.82; 95% CI, −3.19, −0.44; p = .01). Furthermore, NAC treatment resulted in a significant elevation in total antioxidant capacity levels (β 72.28 mmol/L; 95% CI, 11.36, 133.19; p = .02), total glutathione (GSH) levels (β 81.84 μmol/L; 95% CI, 15.40, 148.28; p = .01), and a significant reduction in high‐sensitivity C‐reactive protein levels (β −0.89 mg/L; 95% CI, −1.50, −0.28; p = .005), and homeostasis model of assessment‐insulin resistance (β −0.33; 95% CI, −0.65, −0.009; p = .04), compared with the placebo group.ConclusionIn the current study, improvement in depression and anxiety symptoms as well as some metabolic profiles with NAC treatment for 12 weeks in outpatients with SUD under MMT was detected.
Hydroaminomethylation of Natural Allylic and Homoallylic Alcohols: A Ligand‐Controlled Route to New Amines
Authors: de O. Dias Adelson , Santos Alexandra G. , Delolo Fábio G. , Avendaño‐Villarreal Jesus A. , dos Santos Eduardo N. , Gusevskaya Elena V. 
Published: November 2022

AbstractHydroaminomethylation (HAM) is a tandem catalytic process that allows accessing amines from olefin scaffolds and is perfectly aligned with green chemistry precepts. In this work, HAM was applied to the natural hydroxyolefins: isoprenol, linalool, nerolidol, and isopulegol. Employing 4‐methylpiperidine, morpholine, and 1,2,3,4‐tetrahydroisoquinoline as counterparts, several new, structurally complex amines were prepared from biorenewable, low‐cost substrates, opening a path to exploit this structure diversity in biological activity. By the appropriate choice of rhodium‐based catalytic systems, as well as the reaction conditions, the necessary fine tuning for each counterpart was achieved. The unpromoted rhodium system leaded mostly to aminoalcohols, while certain phosphorus(III)‐promoted rhodium systems afforded amines containing a tetrahydropyran or a tetrahydrofuran moiety in moderate to high yields.
A review on system and materials for aqueous flexible metal–air batteries
Authors: Jiang Lixue , Luo Xiaoxuan , Wang Da‐Wei 
Published: November 2022

AbstractThe exploration of aqueous flexible metal–air batteries with high energy density and durability has attracted many research efforts with the demand for portable and wearable electronic devices. Aqueous flexible metal–air batteries feature Earth‐abundant materials, environmental friendliness, and operational safety. Each part of one metal–air battery can significantly affect the overall performance. This review starts with the fundamental working principles and the basic battery configurations and then highlights on the common issues and the recent advances in designing high‐performance metal electrodes, solid‐state electrolytes, and air electrodes. Bifunctional oxygen electrocatalysts with high activity and long‐term stability for constructing efficient air electrodes in flexible metal–air batteries are summarized including metal‐free carbon‐based materials and nonprecious Co/Fe‐based materials (alloys, metal oxides, metal sulfites, metal phosphates, metal nitrates, single‐site metal–nitrogen–carbon materials, and composites). Finally, a perspective is provided on the existing challenges and possible future research directions in optimizing the performance and lifetime of the flexible aqueous solid‐state metal–air batteries.
Two‐sided influence of dupilumab on alopecia areata co‐existing with severe atopic dermatitis: A case series and literature review
Authors: Fukuyama Masahiro , Kinoshita‐Ise Misaki , Mizukawa Yoshiko , Ohyama Manabu 
Published: November 2022

AbstractObjectivesAlopecia areata (AA) often coexists with atopic dermatitis (AD). Recently, several reports suggested that dupilumab, an interleukin 4 receptor α‐antagonist, administration could be a promising medication not only for severe AD but also for AA concomitant with AD (AD‐AA). At the same time, dupilumab has also been reported to exacerbate AA in AD‐AA cases. Thus, the efficacy of dupilumab on AA in AD‐AA cases remains controversial.MethodsIn this study, we retrospectively analyzed four AD‐AA cases treated with dupilumab to evaluate its influence on AD and AA.ResultsAll cases had suffered from severe AD since childhood and their average eczema area and severity index (EASI) scores prior to dupilumab administration was 43.2 ± 15.0. Three of four cases had moderate to severe multifocal AA, which successfully recovered in response to dupilumab, accompanied by the decrease in serum thymus and activation‐regulated chemokine (TARC) levels and significant improvement of AD, achieving approximately 90% improvement of EASI scores within 3 months. In contrast, the remaining one case developed rapidly progressive hair loss 8 months after the initiation of dupilumab. In this case, AD was incompletely controlled by dupilumab with the elevation of serum TARC level despite AD improvement. The literature review found 39 dupilumab‐treated AD‐AA cases with elaborate description of clinical course; 24 cases with AA improvement, 15 cases with AA exacerbation, or new onset.ConclusionsThese findings alert physicians that use of dupilumab in expectation of AA improvement in AD‐AA cases can lead to unfortunate consequence in some patients.
Syntheses, Properties, and Aggregation Behavior of Novel Carboxylate‐Based Silicone Surfactants
Authors: Meng Lina , Wang Wenyu , Li A. P. Lei , Feng Shengyu 
Published: November 2022

AbstractTwo new anionic silicone surfactants were synthesized for the first time from dichloromethylvinylsilane or trichlorovinylsilane through hydrolysis‐condensation and then thiol‐ene reactions. Their structures were characterized by FT‐IR, 1H NMR and ESI‐MS. The surface tension (γ), critical aggregate concentration (CAC), surface pressure at CAC (
) and minimum surface area per surfactant molecule (
) were studied by surface tension and electrical conductivity, demonstrating their high surface activity at the gas/liquid interface. Transmission electron microscopy measurements showed that uniform spherical aggregates former in aqueous solution for both surfactants. Moreover, the size of the aggregates was determined to be in the range from 50 to 300 nm by dynamic light scattering.
(2‐Vinyltetrazolyl)furoxans as New Potential Energetic Monomers
Authors: Chaplygin Daniil A. , Larin Alexander A. , Meerov Dmitry B. , Monogarov Konstantin A. , Pronkin Dmitry K. , Pivkina Alla N. , Fershtat Leonid L. 
Published: November 2022

AbstractA regioselective approach toward the synthesis of a set of new (2‐vinyltetrazolyl)furoxans as potential energetic monomers has been realized. All target energetic materials were thoroughly characterized by spectral and analytical methods. Moreover, crystal structures of two representative heterocyclic systems were studied by single‐crystal X‐ray diffraction. Prepared high‐energy substances have high combined nitrogen‐oxygen content (63‐71 %), high enthalpies of formation and good detonation parameters (D: 6.7–7.8 km s−1; P: 18–28 GPa). Mechanical sensitivities of the synthesized vinyltetrazoles range these explosives from highly sensitive to completely insensitive. Using calculations of molecular electrostatic potentials (ESP), structural factors influencing the impact sensitivity were revealed. Overall, newly synthesized (2‐vinyltetrazolyl)furoxans are of interest as promising energetic monomers due to the presence of the vinyl moiety and explosophoric heterocyclic combination, while their performance exceeds that of benchmark explosive TNT.
Ultrasmall CuI Nanoparticles Stabilized on Surface of HPMC: An Efficient Catalyst for Fast and Organic Solvent‐Free Tandem Click Chemistry in Water
Authors: Sharma Sudripet , Jasinski Jacek B. , Braje Wilfried M. , Handa Sachin 
Published: November 2022

AbstractA simple and environmentally benign technology for synthesizing ultrasmall CuI nanoparticles (NPs) on the surface of the food additive hydroxypropyl methylcellulose (HPMC) and their application in completely organic solvent‐free tandem alkyne‐azide cycloaddition reactions were reported. The NP catalyst was thoroughly characterized by high‐angle annular dark‐field scanning transmission electron microscopy, high‐resolution transmission electron microscopy, energy‐dispersive X‐ray spectroscopy, and X‐ray photoelectron spectroscopy analysis for its morphology, particle size distribution, chemical composition, and oxidation state analyses. The NP catalyst was highly efficient, affording products in 10–45 min. All products were obtained in high purity by simple filtration, obviating organic solvents from the reaction set‐up to product isolation. The methodology is general and scalable as validated by a broad substrate scope.
Optimization of monocyte gating to quantify monocyte subsets for the diagnosis of chronic myelomonocytic leukemia
Authors: Jurado Rebeca , Huguet Maria , Xicoy Blanca , Cabezon Marta , Jimenez‐Ponce Ari , Quintela David , De La Fuente Cristina , Raya Minerva , Vinets Esther , Junca Jordi , Julià‐Torras Joaquim , Zamora Lurdes , Oriol Albert , Navarro Jose‐Tomas , Calvo Xavier , Sorigue Marc 
Published: November 2022

AbstractBackgroundThe presence of >94% classical monocytes (MO1, CD14++/CD16‐) in peripheral blood (PB) has an excellent performance for the diagnosis of chronic myelomonocytic leukemia (CMML). However, the monocyte gating strategy is not well defined. The objective of the study was to compare monocyte gating strategies and propose an optimal one.MethodsThis is a prospective, single center study assessing monocyte subsets in PB. First, we compared monocyte subsets using 13 monocyte gating strategies in 10 samples. Then we developed our own 10 color tube and tested it on 124 patients (normal white blood cell counts, reactive monocytosis, CMML and a spectrum of other myeloid malignancies). Both conventional and computational (FlowSOM) analyses were used.ResultsComparing different monocyte gating strategies, small but significant differences in %MO1 and percentually large differences in %MO3 (nonclassical monocytes) were found, suggesting that the monocyte gating strategy can impact monocyte subset quantification. Then, we designed a 10‐color tube for this purpose (CD45/CD33/CD14/CD16/CD64/CD86/CD300/CD2/CD66c/CD56) and applied it to 124 patients. This tube allowed proper monocyte gating even in highly abnormal PB. Computational analysis found a higher %MO1 and lower %MO3 compared to conventional analysis. However, differences between conventional and computational analysis in both MO1 and MO3 were globally consistent and only minimal differences were observed when comparing the ranking of patients according to %MO1 or %MO3 obtained with the conventional versus the computational approach.ConclusionsThe choice of monocyte gating strategy appears relevant for the monocyte subset distribution test. Our 10‐color proposal allowed satisfactory monocyte gating even in highly abnormal PB. Computational analysis seems promising to increase reproducibility in monocyte subset quantification.
Portuguese version of the CDR plus NACC FTLD: Validation studies
Authors: Lima Marisa , Tábuas‐Pereira Miguel , Durães João , Faustino Pedro , Simões Mário R. , Kukull Walter , Knopman David S. , Santana Isabel 
Published: November 2022

AbstractIntroductionThe CDR Dementia Staging Instrument PLUS National Alzheimer’s Coordinating Center (CDR plus NACC FTLD) was developed by adding to the standard CDR two extra domains focused on the main features of frontotemporal lobar degeneration (FTLD): language and behavior/personality. We intended to perform the validation studies for the European‐Portuguese population.MethodsA total of 105 participants matched for age, education, and disease staging (35 bvFTD, 35 AD, and 35 controls) were included. A translated‐version of the CDR and the two added domains was administered by a neuropsychologist who was blinded to the diagnosis.ResultsThe bvFTD group had higher baseline CDR plus NACC FTLD scores compared to the AD and controls. Only the sum‐of‐boxes (SB) score, the behavior/personality, and language domains were able to distinguish between clinical groups. Logistic regression analyses showed that adding the behavior/personality domain with or without language significantly enhanced the discriminating ability.DiscussionResults show that the CDR plus NACC FTLD is a reliable tool in the diagnostic process of bvFTD patients and has an added value in distinguishing them from patients with AD.
Unexpected adhesive bowel obstruction after endoscopic submucosal dissection of early sigmoid colon cancer
Authors: Seki Kenta , Sakamoto Taku , Makiguchi Mai Ego , Toyoshima Naoya , Takamaru Hiroyuki , Sekiguchi Masau , Yamada Masayoshi , Sekine Shigeki , Kanemitsu Yukihide , Saito Yutaka 
Published: November 2022

AbstractVarious complications of colorectal endoscopic submucosal dissection (ESD) have been reported, including bleeding, penetration, perforation, and coagulation syndrome. However, the occurrence of bowel obstruction after ESD is rare. We report a case of adhesive bowel obstruction after ESD for a laterally spreading tumor in the sigmoid colon. The 35‐mm tumor was successfully removed by ESD without intraoperative complications. The patient had a fever, lower abdominal pain, and a small amount of bloody stool the day after ESD. Endoscopy revealed minor bleeding from the ESD scar, which was treated by hemostatic clips. Pathological analysis showed adenocarcinoma was exposed to the vertical margin; therefore, the resection was non‐curative. At 39 days after ESD and 36 days after discharge, the patient had abdominal pain and nausea. She was readmitted with a diagnosis of adhesive bowel obstruction. Conservative treatment was ineffective; therefore, she underwent sigmoidectomy combined with partial resection of the small intestine because of small intestinal stenosis caused by inflammation. The pathological examination showed localized peritonitis around the sigmoid colon where ESD was performed. There was more fibrosis along the serous surface of the small intestine than on the sigmoid colon. We concluded that there was a micro‐perforation that could not be detected by endoscopy or physical examination. This case indicates that adhesive bowel obstruction may occur as a complication of ESD.
Removal of natural organic matter fractions by adsorptive asymmetric ceramic membrane functionalized with in situ phytogenic nanoscale zero valent iron: Performance and Fenton cleaning strategy
Authors: Moyo Welldone , Nkambule Thabo T. I. 
Published: November 2022

AbstractExtant literature has demonstrated that conventional water treatment processes especially in developing countries struggle in completely removing detrimental organic loads. Emerging research delineates nanomaterials such as nanoscale zero valent iron (nZVI) to have excellent performance in organic matter removal from aqueous media. In this work, nZVI particles were prepared from the liquor of commercially available green tea and supported on kaolin (K‐nZVI) and investigated as an adsorbent for natural organic matter (NOM) sequestration from aquatic media. Further, the asymmetric ceramic membrane was prepared by incorporating the developed adsorbent on a concrete support for the removal of NOM. A Fenton cleaning strategy was developed to mitigate fouling. The Brunauer–Emmett–Teller (BET) results revealed the developed adsorbent surface area was greater compared to raw kaolin (27.07 and 11.64 m3 g−1, respectively). The scanning electron microscopy (SEM) imagery of the developed adsorbent showed the particle staking was presented as paper slices of varying sizes, an indication of dispersed particles with characteristic plate‐like fragments. The synthesized membrane exhibited a pHZPC value of 4.79 ± 0.03. This meant at pH above 4.79 ± 0.03, the membrane would be negatively charged, and conversely at pH below the pHZPC value. Membrane fouling due to bovine serum albumin (BSA) deposition showed a 50% flux decline in the first 60 min, coinciding with the rapid adsorption capacity within the same time frame. The optimal cleaning parameters of pH (4.5) and H2O2 (5 mM) gave the best flux recovery rates. This work demonstrated an efficient Fenton cleaning strategy to regenerate the developed membrane.