bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint optimization algorithm of user association and power control based on spatial traffic distribution
Authors: Wang Weipeng , Zhao Jihong , Qu Hua , Zhang Yanpeng , Ren Gongye 
Published: July 2022

Abstract5G networks must reduce network overhead while meeting user needs. Based on the flow model, this paper jointly optimizes the user association and power control in cellular networks, aiming at achieving a reasonable compromise between user delay and network energy consumption. Unlike previous snapshot models, flow models focus on the spatial distribution of traffic demand instead of the specific location of users. We consider a nonuniformity of spatial traffic distribution and load coupling among base stations (BSs). Firstly, an iterative algorithm is proposed to solve the optimal user association strategy under certain power of BSs. Then, a greedy power adjustment and user association algorithm (GPA‐UA) is proposed to further optimize the objective function. The simulation results show that the proposed algorithm can reduce both user delay and network energy consumption in most cases, and the performance of the proposed algorithm is approximate to the Optimal scheme while GPA‐UA has lower complexity.
Determination of the lactose and galactose content of common foods: Relevance to galactosemia
Authors: Shakerdi Loai A. , Wallace Leonie , Smyth Georgina , Madden Nora , Clark Anne , Hendroff Una , McGovern Marianne , Connellan Sarah , Gillman Barbara , Treacy Eileen P. 
Published: July 2022

AbstractClassical galactosemia (CG) is a disorder of galactose metabolism which results from deficiency of the enzyme galactose‐1‐phosphate uridylyl transferase (GALT). Treatment consists of immediately eliminating galactose from the diet in the new‐born and lifelong restriction of dietary galactose. The inclusion of a wider variety of foods for people with CG may provide many benefits, including improved nutritional adequacy and quality of life. Galactose plays an important role in glycosylation of glycoproteins and glycolipids. Moderate liberalization of galactose restriction has been shown to improve immunoglobulin G (IgG) glycosylation for some individuals with CG. Moreover, recent outcome research suggests that strict restriction of nondairy galactose may have more unfavorable outcomes than moderate liberalization in CG patients. In the current work, based on patient feedback, we have analyzed the lactose and galactose content of different foods available in Ireland. These include a range of cheeses, yogurts, pizzas, soups, biscuits, cakes, pastries, crackers, mayonnaises, salad creams, fat spreads, crisps, corn chips, salamis, and gravies. This work provides information to support the development of a practical food‐based approach to facilitate analysis of dietary galactose intake and to possibly increase overall variety of food choices for people with CG.
Stable isotope geochemistry and microfossil assemblages of carbonate rocks in the ophiolite mélange zone of the Indo–Myanmar orogenic Belt, NE India: Implications on age and depositional environment
Authors: Singh Athokpam Krishnakanta , Guruaribam Venus , Singh Yengkhom Raghumani , Singh Nongmaithem Ibotombi , Singh Leimapokpam Romendro , Chaubey Monika , Tewari Vinod Chandra , Singh Wangkheimayum Inaocha , Lakhan Nongmaithem , Devi Loitongbam Debala , Chanu Rajkumari Sanalembi 
Published: July 2022

A comprehensive data of whole‐rock and stable isotopic geochemistry along with microfossil assemblages of the carbonate rocks of the ophiolite mélange zone of the Indo–Myanmar orogenic Belt (IMOB), north‐east India are discussed, to determine the influence of terrigenous contamination during the formation of these carbonate rocks and also to understand their depositional environment and ages. These carbonate rocks contain a diverse fauna with the dominance of foraminiferal assemblages of planktonic foraminifera (Globotruncana sp. and Heterohelix sp., etc.) which indicates they were formed during the Santonian to Maastrichtian age. Based on chemical compositions, these carbonate rocks have been identified as limestone (CaO/MgO > 50.1) to slightly dolomitic limestone (9.1 < CaO/MgO < 50.1). Total rare earth element (REE) contents in these carbonates are variable (22.39–146.05 ppm). The Post‐Archean Australian Shale (PAAS)‐normalized REE + Y patterns of these carbonates exhibit seawater‐like REE patterns with LREE depletion and relative HREE enrichment with negative Ce anomalies (Ce/Ce* = 0.32–0.79) and positive Y (4.42–27.81 ppm) and Eu anomalies (Eu/Eu* = 1.11–1.86), suggesting that they were deposited under an oxygenated environment with contamination by hydrothermal activity. They are also depleted in δ13C 0/00 (PDB) (1.02–1.570/00) and δ18O 0/00 (PDB) (−6.37 to −9.00%) values which characterize marine precipitates. Eu anomalies and spread in negative δ18O 0/00 (PDB) values to a lesser extent of δ13C 0/00 (PDB) values of these carbonates suggest their formation was altered by diagenesis in the shallow marine environment. Our new whole‐rock and stable isotope geochemical characteristics, in conjunction with microfacies, suggest that the investigated carbonate rocks might have been formed in low‐energy environments, and deposited in neritic to bathyal palaeoenvironments during the Santonian to Maastrichtian interval.
A hierarchical anatomical framework and workflow for organizing stereotactic encephalography in epilepsy
Authors: Zheng Bryan , Hsieh Ben , Rex Nathaniel , Lauro Peter M. , Collins Scott A. , Blum Andrew S. , Roth Julie L. , Ayub Neishay , Asaad Wael F. 
Published: July 2022

AbstractStereotactic electroencephalography (SEEG) is an increasingly utilized method for invasive monitoring in patients with medically intractable epilepsy. Yet, the lack of standardization for labeling electrodes hinders communication among clinicians. A rational clustering of contacts based on anatomy rather than arbitrary physical leads may help clinical neurophysiologists interpret seizure networks. We identified SEEG electrodes on post‐implant CTs and registered them to preoperative MRIs segmented according to an anatomical atlas. Individual contacts were automatically assigned to anatomical areas independent of lead. These contacts were then organized using a hierarchical anatomical schema for display and interpretation. Bipolar‐referenced signal cross‐correlations were used to compare the similarity of grouped signals within a conventional montage versus this anatomical montage. As a result, we developed a hierarchical organization for SEEG contacts using well‐accepted, free software that is based solely on their post‐implant anatomical location. When applied to three example SEEG cases for epilepsy, clusters of contacts that were anatomically related collapsed into standardized groups. Qualitatively, seizure events organized using this framework were better visually clustered compared to conventional schemes. Quantitatively, signals grouped by anatomical region were more similar to each other than electrode‐based groups as measured by Pearson correlation. Further, we uploaded visualizations of SEEG reconstructions into the electronic medical record, rendering them durably useful given the interpretable electrode labels. In conclusion, we demonstrate a standardized, anatomically grounded approach to the organization of SEEG neuroimaging and electrophysiology data that may enable improved communication among and across surgical epilepsy teams and promote a clearer view of individual seizure networks.
MeCP2 loss‐of‐function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance
Authors: Horvath Patricia M. , Piazza Michelle K. , Kavalali Ege T. , Monteggia Lisa M. 
Published: July 2022

AbstractRett syndrome is a leading cause of intellectual disability in females primarily caused by loss of function mutations in the transcriptional regulator MeCP2. Loss of MeCP2 leads to a host of synaptic phenotypes that are believed to underlie Rett syndrome pathophysiology. Synaptic deficits vary by brain region upon MeCP2 loss, suggesting distinct molecular alterations leading to disparate synaptic outcomes. In this study, we examined the contribution of MeCP2's newly described role in miRNA regulation to regional molecular and synaptic impairments. Two miRNAs, miR‐101a and miR‐203, were identified and confirmed as upregulated in MeCP2 KO mice in the hippocampus and cortex, respectively. miR‐101a overexpression in hippocampal cultures led to opposing effects at excitatory and inhibitory synapses and in spontaneous and evoked neurotransmission, revealing the potential for a single miRNA to broadly regulate synapse function in the hippocampus. These results highlight the importance of regional alterations in miRNA expression and the specific impact on synaptic function with potential implications for Rett syndrome.
Laser‐enabled delivery of antiretroviral drugs into HIV‐1 infected TZM‐bl cells
Authors: Maphanga Charles , Manoto Sello , Mabena Chemist , Ombinda‐Lemboumba Saturnin , Maaza Malik , Mthunzi‐Kufa Patience 
Published: July 2022

AbstractThe use of femtosecond laser to create sub‐microscopic transient pores on the cell membrane allowing exogenous material into mammalian cells has become a very efficient optical delivery method over the past decade. This study focuses on laser‐enabled delivery of antiretroviral (ARV) drugs into HIV‐1 infected TZM‐bl cells in vitro. A 1 kHz femtosecond laser emitting at a wavelength of 800 nm was used to photoporate cells at 6.5 μW. Trypan blue was used for characterisation and its uptake was quantified using Matlab software. Cell membrane damage was assessed using the lactate dehydrogenase (LDH) assay while HIV‐1 infection was assessed using luciferase assay. Our results showed successful delivery of ARVs into HIV‐1 infected cells without compromising their cell membranes, subsequently reducing the level of infection. The LDH assay showed no significant cell membrane damage of laser‐treated cells, and the luciferase assay demonstrated significant reduction in the level of HIV‐1 infection.
A high spatial resolution osteogenic differentiation in human mesenchymal stem cells induced by femtosecond laser
Authors: Liu Shiyue , Chen Dihan , Xie Zhenming , Zhao Shirui , Tang Wanyi , He Hao , Ho Yi‐Ping , Ho Ho‐Pui , Kong Siu‐Kai 
Published: July 2022

AbstractA variety of physical and chemical methods have been developed in research laboratories for the induction of stem cell differentiation. However, the use of exogenous chemicals and materials may limit their widespread utility in clinics. To develop a clean and precise induction approach with minimal invasion, we reported here that 1‐second stimulation by a tightly focused femtosecond laser (fsL) (140 mW/μm2, 200 fs) can modulate the signaling systems in human mesenchymal cells, such as intracellular calcium and reactive oxygen species. Upon stimulation on an automatic platform, hMSCs were found to express osteoblastic markers and form calcium‐rich deposits. Moreover, tissue mineralization was observed when the fsL‐illuminated hMSCs were ectopically transplanted into nude mice. Collectively, we described a novel and non‐contact optical stimulation method for cell differentiation with high spatiotemporal resolution.
Preparation and characterization of Schiff base nickel complexes and their application in the coupling reaction of cyclohexene oxide and carbon dioxide
Authors: Hsu Shih‐Hsien , Chen Hung‐Chih , Hung Yu‐Ching , Li Yi‐Xuan , Liu Guan‐Lin , Ko Bao‐Tsan , Lin Chu‐Chieh 
Published: July 2022

AbstractA series of novel nickel complex (1–10) supported by NNO‐tridentate Schiff‐base ligands (L1H–L10H) were synthesized and used as catalysts for the reaction of cyclohexene oxide (CHO) and carbon dioxide. Structure determination reveals that all of these complexes are di‐nuclear species with either hexa‐coordinated Ni centers [(OAc)Ni(μ‐L)2(μ‐H2O)Ni(OAc)] (1–6, 9–10) or penta‐coordinated Ni centers [(LNi(μ‐OAc)2NiL] (7–8) with respect to various electronic and steric effect. Interestingly, experimental results indicated that these complexes were inactive in the reaction of CO2 and CHO in the absence of co‐catalysts. However, they exhibited efficient activity and high selectivity yielding cyclic carbonate in the presence of ammonium halides. Among them, complexes with more steric bulky ligand showed somewhat higher activity. Kinetic studies reveal the reaction of CHO and CO2 catalyzed by 4 in the presence of 4 equiv of nBu4NCl as co‐catalyst yielding cyclic carbonate with active energy (ΔG‡) of 59.1 kJ/mol, ΔH‡ of 55.86 kJ/mol and ΔS‡ of −118.28 J/(mol × K) indicating association of substrates occurs prior to the rate‐determining step.
Reference intervals of anti‐Müllerian hormone in Korean women
Authors: Choi Rihwa , Lee Sang Gon , Lee Eun Hee 
Published: July 2022

AbstractBackgroundLimited data are available with reference intervals of serum anti‐Müllerian hormone (AMH) level in Korean women.MethodsWe retrospectively reviewed serum AMH test results performed with automated electrochemiluminescence immunoassay in Korean women who visited health promotion centers between January 2019 and December 2020. Serum AMH results by age group were compared with previously reported reference intervals.ResultsDuring the 2‐year study period, a total of 1953 AMH test results from Korean women (age 20–49 years) undergoing general health checkups were obtained. Serum AMH level differed significantly by age group. Peak AMH level was observed at age 25–29 years and decreased to undetectable for subjects older than 44 years. The 2.5th, 5th, and 10th percentile values of the present study were comparable with previously assessed lower limits of reference intervals. The upper limit of the reference interval defined as the 97.5th percentile value in women younger than 35 years was higher than that of Western populations. The 90th percentile value of the present study population was similar to the 95th or 97.5th percentile value of reference intervals for Western populations of women younger than 35 years.ConclusionUnderstanding patient populations and differences in reference intervals by age group and measurement method can help guide clinical decisions and clinical laboratory analysis.
An insight into the diagnostic and prognostic value of HOX A13’s expression in non‐muscle invasive bladder cancer
Authors: Setti Boubaker Nouha , Gurtner Aymone , Trabelsi Nesrine , Manni Isabella , Blel Ahlem , Saadi Ahmed , Chakroun Marouene , Naimi Zeineb , Zaghbib Selim , Ksontini Meriam , Meddeb Khedija , Rammeh Soumaya , Ayed Haroun , Chebil Mohamed , Piaggio Giulia , Ouerhani Slah 
Published: July 2022

AbstractBackgroundSeveral studies have interrogated the molecular pathways and their interacting genes underlying bladder cancer (BCa) tumorigenesis, yet, the role of homeobox genes is still poorly understood. Specifically, HOXA13, which plays an important role as a major actor in the urogenital tract's development.MethodsImmunohistochemical (IHC) staining was performed to inspect the differential expression of HOXA13 protein in non‐muscle‐invasive bladder cancer (NMIBC) and non‐tumoral tissues. A semiquantitative scoring system was adopted to evaluate the IHC labeling. Correlation to clinical parameters was performed by descriptive statistics. Overall survival was estimated by the Kaplan–Meier method and Cox regression model. The functional HOX A13 protein association networks (PPI) were obtained using String 11.0 database.ResultsHOX A13 exhibited cytoplasmic and nuclear staining. Its expression levels were lower in high‐grade NMIBC (HG NMIBC) compared to low‐grade ones (LG NMIBC). The expression of HOX A13 was correlated to tumor grade (LG/HG) (p = 0.036) and stage (TA/T1) (p = 0.036). Nevertheless, its expression was not correlated to clinical parameters and was not able to predict the overall survival of patients with HG NMIBC. Finally, PPI analysis revealed that HOX A13 seems to be a part of a molecular network holding mainly PBX1, MEIS, ALDH1A2, HOX A10, and HOX A11.ConclusionThe deregulation of HOX A13 is not associated with the prognosis of BCa. It seems to be rather implicated in the early initiation of urothelial tumorigenesis and thus may serve as a diagnostic marker in patients with NMIBC. Further experimentations on larger validation sets are mandatory.
Pleiotropic roles of evolutionarily conserved signaling intermediate in toll pathway (ECSIT) in pathophysiology
Authors: Chaitanya Nyshadham S. N. , Tammineni Prasad , Nagaraju Ganji Purnachandra , Reddy Aramati BM 
Published: July 2022

AbstractThe evolutionarily conserved signaling intermediate in toll pathway (ECSIT) is a cytosolic adaptor protein associated with the toll‐like receptor pathway. It has a distinct N‐terminal mitochondrial targeting sequence, pentatricopeptide repeat motif, and a C‐terminal pleckstrin homology domain. ECSIT regulates many biological processes like embryonic development, inflammation, cardiac function, and assembly of mitochondrial complex I. Besides, ECSIT also interacts with multiple signaling intermediates like tumor necrosis receptor associated factor 6 and retinoic acid inducible gene 1 as well as regulates various pathways in the microcellular environment. However, molecular details of ECSIT functions in pathophysiology remain elusive. This review summarizes the diverse functions of ECSIT and its involvement in pathophysiological conditions such as Alzheimer's, oxidative stress, and infection.
Electric field enhanced heterogeneous Fenton reaction: simultaneous pollutant degradation and catalyst reactivation
Authors: Zhou Zijie , Yin Xu , Li Wei , Liu Run , Wei Kajia , Liu Xiaodong , Sun Xiuyun , Han Weiqing 
Published: July 2022

AbstractBACKGROUNDTraditional Fe‐based heterogeneous Fenton catalysts have the problem of a low generation rate of Fe(II) from Fe(III), and this leads to poor reaction efficiency and catalyst deactivation. In this work, Fe3O4@N‐MWCNT catalyst with both strong magnetism and high electrical conductivity was synthesized. In addition, a novel unibody degradation‐reactivation reactor was designed for simultaneous pollutant degradation and catalyst reactivation.RESULTSThe X‐ray Diffraction (XRD) patterns and Scanning Electron Microscope (SEM) images reveal the great dispersity of Fe3O4 loaded on oxidized‐MWCNT. The Vibrating Sample Magnetometer (VSM) tests and electrochemical characterization confirmed the strong magnetism, high electrical conductivity, and good capacitance performance of the catalyst. The optimum condition of heterogeneous Fenton degradation experiments was investigated. A favorable recovery of Fe(II) was confirmed through the detection of the Fe(II): Fe(III) ratio from X‐ray Photoelectron Spectroscopy (XPS) characterization.CONCLUSIONThe combination of Fe3O4 and MWCNT can significantly increase the heterogeneous Fenton catalytic activity of the catalyst. Under the assistance of a finely controlled flow pattern and an applied magnetic field, three different processes (including heterogeneous Fenton reaction, electrochemical oxidation, and catalyst reactivation) were joined organically into a synergistic reaction system. It is demonstrated that the catalyst can replenish the sacrificed electrons during the reactivation process and improve its cycling performance. © 2022 Society of Chemical Industry (SCI).
Local Patterns in 2‐Year T1ρ and T2 Changes of Hip Cartilage Are Related to Sex and Functional Data: A Prospective Evaluation on Hip Osteoarthritis Participants
Authors: Roach Koren E. , Souza Richard B. , Majumdar Sharmila , Pedoia Valentina 
Published: July 2022

BackgroundAlthough T1ρ and T2 have emerged as early indicators for hip osteoarthritis (OA), there is little information regarding longitudinal changes across the cartilage in the early stages of this disease.PurposeTo characterize the variability in 2‐year hip cartilage T1ρ and T2 changes and investigate associations between these patterns of change and common indicators of hip OA.Study TypeProspective.PopulationA total of 25 women (age: 51.9 ± 16.3 years old; BMI: 22.6 ± 2.0 kg/m2) and 17 men (age: 55.8 ± 14.9 years old; body mass index (BMI): 24.4 ± 3.8 kg/m2) who were healthy or with early‐to‐moderate hip OA.Field Strength/SequenceA 3 T MRI (GE), 3D combined T1ρ/T2 magnetization‐prepared angle‐modulated partitioned k‐space spoiled gradient echo snapshots.AssessmentPrincipal component (PC) analysis of Z‐score difference maps of 2‐year changes in hip cartilage T1ρ and T2 relaxation times, participant hip disability and osteoarthritis outcome scores (HOOS) and functional tests at 2‐year follow‐up.Statistical TestsShapiro–Wilk test, unpaired t‐tests, Kruskal Wallis tests, Pearson or Spearman (ρ) correlations. Significance was set at P < 0.05.ResultsWomen (−6.40 ± 14.48) had significantly lower T1ρ PC1 scores than men (10.05 ± 26.15). T1ρ PC4 was significantly correlated with HOOSsport, HOOSsymptoms, HOOSpain, HOOSadl, and HOOSqol at 2‐year follow‐up (ρ: [0.36, 0.50]). T1ρ PC2 and PC4 were significantly correlated with 30‐second chair test (ρ = −0.39 and ρ = 0.24, respectively) and side plank (ρ = −0.32 and ρ = 0.21). T1ρ and T2 PC2 were significantly correlated with 40 m walk test (ρ = 0.34 and ρ = 0.31) and 30‐second chair rise test (ρ = −0.39 and ρ = −0.32).Data ConclusionMen exhibited accelerated T1ρ increases across the femoral cartilage compared to women, suggesting sex should be considered when evaluating early hip OA. Participants with poorer HOOS and function exhibited greater T1ρ and T2 increases in superior and anterior femoral cartilage and greater T1ρ increases in the anterior femoral cartilage. These patterns of short‐term relaxometry increases could indicate hip OA progression.Evidence Level2Technical EfficacyStage 3
A comparative study on electromagnetic quasistatic time‐domain field calculations
Authors: Henkel Marvin‐Lucas , Kasolis Fotios , Schöps Sebastian , Clemens Markus 
Published: July 2022

AbstractElectromagnetic quasistatic field models, which take into consideration resistive, inductive, and capacitive effects, have been introduced for electrical engineering applications whose geometrical characteristics, combined with the operational frequencies, suggest negligible radiation phenomena. Here, a monolithic variant of a previously proposed two‐step electromagnetic quasistatic algorithm and a two‐step time‐domain Maxwell formulation are presented, together with relevant initial‐boundary value problems. In view of numerical experiments, the fields that are obtained with the two‐step electromagnetic quasistatic algorithm, its monolithic variant, and the two‐step time‐domain Maxwell formulation are compared and turn out to be in good agreement.