bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time trends in emotional well-being and self-esteem in children and adolescents during the COVID-19 pandemic
Authors: Goto Ryunosuke , Piedvache Aurelie , Hangai Mayumi , Yamaoka Yui , Sampei Mariko , Sawada Naomi , Okubo Yusuke , Tanaka Kyoko , Morisaki Naho , Hosozawa Mariko 
Published: November 2022

Abstract
Objective
Given their unique COVID-19 pandemic experience, it is necessary to evaluate the mental health of youth beyond the initial stages of the pandemic, in relation to the stringency of the social distancing measures. We aimed to describe long-term trends in emotional well-being and self-esteem among youth in Japan during the pandemic.

Method
Using serial cross-sectional data from April 2020 to December 2021, we evaluated the trends in emotional well-being and self-esteem of youth aged 6–17 years using the self-report KINDL questionnaire, weighted to represent the age and gender distributions in the Japanese population. We then tested the associations between emotional well-being and self-esteem and stringency of social distancing policies, measured using the Oxford COVID-19 Stringency Index. Analyses were also stratified by gender and age group.

Results
The emotional well-being and self-esteem of youth improved transiently in 2020, followed by a slight worsening trend into 2021. While emotional well-being stayed lower compared to initial levels nearly 2 years into the pandemic, self-esteem began to improve by late 2021. 12–17 year-olds had lower emotional well-being and self-esteem compared to 6–11 year-olds throughout the study period. Females had lower emotional well-being than males in May 2020 and lower self-esteem than males in May and September/October 2020. More stringent social distancing measures were associated with lower emotional well-being and self-esteem, especially 6–11 year-olds’ self-esteem and females’ emotional well-being.

Conclusion
During the COVID-19 pandemic, older youth tended to have lower emotional well-being and self-esteem than younger youth. Younger and female youth were especially vulnerable to stringent social distancing measures.
UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis
Authors: Zhao Liang , Kang Min , Liu Xiaomeng , Wang Zhenran , Wang Yan , Chen Haiqiang , Liu Wenhui , Liu Shiqian , Li Baibei , Li Chong , Chang Antao , Tang Bo 
Published: November 2022

Abstract
Background
Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiquitin–proteasome system facilitates the turnover of most intracellular proteins with E3 ligase conferring the target selection and specificity. Ubiquitin protein ligase E3 component N-recognin 7 (UBR7), among the least studied E3 ligases, recognizes its substrate through a plant homeodomain (PHD) finger. Here, we bring into focus on its suppressive role in glycolysis and HCC tumorigenesis, dependent on its E3 ubiquitin ligase activity toward monoubiquitination of histone H2B at lysine 120 (H2BK120ub).

Methods
In this study, we carried out high-throughput RNAi screening to identify epigenetic candidates in regulating lactic acid and investigated its possible roles in HCC progression.

Results
UBR7 loss promotes HCC tumorigenesis both in vitro and in vivo. UBR7 inhibits glycolysis by indirectly suppressing HK2 expression, a downstream target of Nrf2/Bach1 axis. Mechanically, UBR7 regulates H2BK120ub to bind to Keap1 promoter through H2BK120ub monoubiquitination, thereby modulating Keap1 expression and downstream Nrf2/Bach1/HK2 signaling. Pharmaceutical and genetic inhibition of glycolytic enzymes attenuate the promoting effect of UBR7 deficiency on tumor growth. In addition, methyltransferase ALKBH5, downregulated in HCC, regulated UBR7 expression in an m6A-dependent manner.

Conclusions
These results collectively establish UBR7 as a critical negative regulator of aerobic glycolysis and HCC tumorigenesis through regulation of the Keap1/Nrf2/Bach1/HK2 axis, providing a potential clinical and therapeutic target for the HCC treatment.
Autologous hematopoietic stem cell transplantation improves long-term survival—data from a national registry
Authors: Blank Norbert , Schmalzing Marc , Moinzadeh Pia , Oberste Max , Siegert Elise , Müller-Ladner Ulf , Riemekasten Gabriela , Günther Claudia , Kötter Ina , Zeidler Gabriele , Pfeiffer Christiane , Juche Aaron , Jandova Ilona , Ehrchen Jan , Susok Laura , Schmeiser Tim , Sunderkötter Cord , Distler Jörg H. W. , Worm Margitta , Kreuter Alexander , Keyßer Gernot , Lorenz Hanns-Martin , Krieg Thomas , Hunzelmann Nicolas , Henes Jörg ,   on behalf of the German Network for Systemic Sclerosis
Published: November 2022

Abstract
Background
Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc.

Objectives
To assess the safety and efficacy of HSCT for patients with SSc and to compare these with non-HSCT patients in a control cohort with adjusted risk factors.

Methods
A retrospective analysis of data from the multicentric German network for systemic scleroderma (DNSS) with 5000 patients with SSc. Control groups consisted of all patients with diffuse cutaneous (dc)-SSc (group A) and an adjusted high-risk cohort of male patients with Scl70-positive dc-SSc (group B).

Results
Eighty SSc patients received an HSCT 4.1 ± 4.8 years after SSc diagnosis. Among them, 86.3% had dc-SSc, 43.5% were males, and 71.3% were positive for Scl70 antibodies. The control group A (n=1513) showed a significant underrepresentation of these risk factors for mortality. When the survival of the control group B (n=240) was compared with the HSCT group, a lower mortality of the latter was observed instead. Within 5 years after HSCT, we observed an improvement of the mRSS from 17.6 ± 11.5 to 11.0 ± 8.5 (p=0.001) and a stabilization of the DLCO. We did not see differences in transplant-related mortality between patients who received HSCT within 3 years after SSc diagnosis or later.

Conclusion
Our analysis of real-life data show that the distribution of risk factors for mortality is critical when HSCT cohorts are compared with non-HSCT control groups.
Diabetes management behaviors associated with depression in the U.S.
Authors: Lai Tim C. , McDaniel Cassidi C. , Chou Chiahung 
Published: November 2022

Abstract
Background
There is a lack of nationally representative evidence from the U.S. investigating the relationships between depression and diabetes management behaviors. Our study aimed to assess the associations between diabetes management behaviors and depression status, and to compare U.S. population-level percentages of diabetes management behaviors among patients with and without depression.

Methods
A cross-sectional study was conducted using population-based survey data to assess patient-reported variables retrospectively. We used the Behavioral Risk Factor Surveillance System (BRFSS) data and included states in the U.S. that continuously adopted the diabetes optional modules in 2013, 2015, 2017, and 2019. We included U.S. adults (≥ 18 years old) with self-reported diabetes in our analysis. Main outcomes were diabetes management behaviors (i.e., self-check for blood glucose and feet sores/irritation, regular diabetes clinical visit, HbA1c check, professional feet check, and dilated eye examination) and lifestyle behaviors (i.e., exercise, smoking, and alcohol consumption).

Results
Among the 74,011 respondents with diabetes, patients with depression had a higher likelihood of performing routine HbA1c checks (adjusted odds ratio (AOR) = 1.12; 95% CI 1.01–1.23) but had a lower likelihood to perform regular self-check for blood glucose (AOR = 0.91; 95% CI 0.84–0.99), receive professional feet checks (AOR = 0.87; 95% CI 0.79–0.95), and receive a dilated eye examination (AOR = 0.89; 95% CI 0.82–0.98). For lifestyle behaviors, patients with depression were more likely to smoke (No smoking (AOR) = 0.65; 95% CI = 0.59–0.72) and less likely to engage in sufficient exercise time (AOR = 0.69; 95% CI 0.63–0.75). There were no significant associations between depression and other behaviors, including self-check for feet sores/irritation (AOR = 0.99; 95% CI 0.92–1.08), regular diabetes clinical visit (AOR = 1.03, 95% CI 0.94–1.13), and alcohol consumption (AOR = 1.01, 95% CI 0.92–1.10).

Conclusions
The association between depression status and diabetes management behaviors varied. People with depression were positively associated with HbA1c checks. However, less uptake of other behaviors may indicate the needs for improvement in diabetes management.
Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol
Authors: Dawson Jacqueline K. , Kang Dong-Woo , Barnes Oscar , Wilson Rebekah L. , Norris Mary K. , Dieli-Conwright Christina M. 
Published: November 2022

Abstract
Background
Symptom burden and adverse treatment effects can negatively impact physical function, health-related outcomes, and quality of life in cancer survivors. Resistive exercise that improves skeletal muscle function can ameliorate these complications, but the central role of the skeletal muscle in mediating improvements in patient-related outcomes has not been explored. This protocol describes the rationale and methods for a systematic review that aims to determine the effects of resistive exercise on the skeletal muscle hypertrophy, muscle performance, and muscle-related biomarkers in cancer survivors.

Methods
A systematic review will be conducted on peer-reviewed randomized controlled trials (RCTs) that employ resistive exercise interventions for cancer survivors. The following electronic databases will be searched: AMED, CENTRAL, CINAHL, CIRRIE, EMBASE, MEDLINE, PEDro, REHABDATA, Scopus, and SPORTDiscus. Studies will be considered for inclusion if they present quantitative data in adult cancer survivors on skeletal muscle characteristics (e.g., muscle mass), muscle performance (e.g., strength), or skeletal muscle-related biomarkers (e.g., myocellular satellite cells). Secondary outcomes will be physical function (e.g., stair climb) and patient-reported outcomes (e.g., fatigue). Data will be reported through a narrative that describes study design, participants, interventions, and outcome characteristics.

Discussion
This systematic review will help clarify the influence of resistive exercise on factors relating to the skeletal muscle in adult cancer survivors. Findings may provide insight into optimal exercise selection for evidence-based practice.

Systematic review registration
PROSPERO: #277791 [under review]
Determinants of the sustainability and growth of micro and small enterprises (MSEs) in Ethiopia: literature review
Authors: Teka Beza Muche 
Published: November 2022

AbstractThe role of micro and small enterprises (MSEs) has been recognized in Ethiopia at the strategic and policy levels. They are considered as a way to create jobs, alleviate poverty, ensure food security, and promote private sector development. Despite several government programs and support schemes aimed at empowering MSEs to be more competitive and sustainable, they continue to fail at alarming rates. Previous studies revealed that the failure rate of MSEs in developing countries like Ethiopia is higher than in developed countries due to a variety of internal and external factors. Thus, the objective of this study was to identify the major factors that commonly affect the sustainability and growth of MSEs in Ethiopia through systematic literature review. In order to achieve the objective of the study; published previous research works (journal articles) in the manufacturing and service sector from 2006 to 2021 were used. The findings from different empirical studies revealed that financial factors, marketing factors, political-legal variables, lack of adequate infrastructure, technological factors and manager or owner personal characteristics are the major factors that commonly determine the sustainability and growth of MSEs in Ethiopia. Finally, the study suggested that government, non-governmental organizations (NGOs), and financial institutions should give great attention towards the sustainability and growth of MSEs in Ethiopia.
Quantifying the employment impacts of gross exports: a global accounting perspective
Authors: Llop Maria 
Published: November 2022

AbstractThis article presents a method for quantifying the (domestic) employment consequences directly attributed to gross exports by taking into account the complex and global nature of production chains. Using a multi-country input–output (IO) structure of world production, the method derives measurements for the number of jobs and amount of labour income supported by a country’s export-related production. By quantifying how much domestic employment is determined by a country’s export activity, it offers a complementary (labour-focused) view on the more common (value-added focused) analyses for evaluating the economic impact of trade. This approach highlights the importance of exports in creating jobs and labour income, especially in the European Union and China. In contrast, gross exports in the United States show a (comparatively) weak influence in supporting US employment.
Reinforcement learning method for machining deformation control based on meta-invariant feature space
Authors: Zhao Yujie , Liu Changqing , Zhao Zhiwei , Tang Kai , He Dong 
Published: November 2022

AbstractPrecise control of machining deformation is crucial for improving the manufacturing quality of structural aerospace components. In the machining process, different batches of blanks have different residual stress distributions, which pose a significant challenge to machining deformation control. In this study, a reinforcement learning method for machining deformation control based on a meta-invariant feature space was developed. The proposed method uses a reinforcement-learning model to dynamically control the machining process by monitoring the deformation force. Moreover, combined with a meta-invariant feature space, the proposed method learns the internal relationship of the deformation control approaches under different stress distributions to achieve the machining deformation control of different batches of blanks. Finally, the experimental results show that the proposed method achieves better deformation control than the two existing benchmarking methods.
Development of therapeutic antibodies for the treatment of diseases
Authors: Wang Zeng , Wang Guoqing , Lu Huaqing , Li Hongjian , Tang Mei , Tong Aiping 
Published: November 2022

AbstractSince the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in 1986, 165 antibody drugs have been approved or are under regulatory review worldwide. With the approval of new drugs for treating a wide range of diseases, including cancer and autoimmune and metabolic disorders, the therapeutic antibody drug market has experienced explosive growth. Monoclonal antibodies have been sought after by many biopharmaceutical companies and scientific research institutes due to their high specificity, strong targeting abilities, low toxicity, side effects, and high development success rate. The related industries and markets are growing rapidly, and therapeutic antibodies are one of the most important research and development areas in the field of biology and medicine. In recent years, great progress has been made in the key technologies and theoretical innovations provided by therapeutic antibodies, including antibody–drug conjugates, antibody-conjugated nuclides, bispecific antibodies, nanobodies, and other antibody analogs. Additionally, therapeutic antibodies can be combined with technologies used in other fields to create new cross-fields, such as chimeric antigen receptor T cells (CAR-T), CAR-natural killer cells (CAR-NK), and other cell therapy. This review summarizes the latest approved or in regulatory review therapeutic antibodies that have been approved or that are under regulatory review worldwide, as well as clinical research on these approaches and their development, and outlines antibody discovery strategies that have emerged during the development of therapeutic antibodies, such as hybridoma technology, phage display, preparation of fully human antibody from transgenic mice, single B-cell antibody technology, and artificial intelligence-assisted antibody discovery.
Ατομική και οικογενειακή ανθεκτικότητα: ο ρόλος της γονικότητας
Authors: Μιχαηλίδου Μαρίνα , Γεωργίου Στέλιος Ν. 
Published: November 2022

Σκοπός της παρούσας θεωρητικής περιγραφής είναι να σκιαγραφηθεί το φαινόμενο της ανθεκτικότητας ως ένα συστημικό και πολυδιάστατο φαινόμενο που μπορεί να θωρακίσει τα παιδιά και τις οικογένειες απέναντι σε παράγοντες επικινδυνότητας που αυξάνουν την πιθανότητα δημιουργίας προβλημάτων στην ανάπτυξη του παιδιού και της οικογένειας. Επιπρόσθετα, συζητείται ο ρόλος που διαδραματίζει η γονικότητα στη διαμόρφωση της ατομικής ανθεκτικότητας του παιδιού και της ανθεκτικότητας του οικογενειακού συστήματος, αλλά και ο πιθανός συνδετικός ρόλος της γονικότητας ανάμεσα στην ανθεκτικότητα των δυο συστημάτων (ατομικού και οικογενειακού). Τέλος, γίνονται εισηγήσεις για περαιτέρω διερεύνηση σε θέματα που θα οδηγήσουν στην κατανόηση του τρόπου με τον οποίο η γονικότητα προσδιορίζει την ανθεκτικότητα των δυο συστημάτων.
Post-acute sequelae of COVID-19 among hospitalized patients in Estonia: Nationwide matched cohort study
Authors: Tisler Anna , Stirrup Oliver , Pisarev Heti , Kalda Ruth , Meister Tatjana , Suija Kadri , Kolde Raivo , Piirsoo Marko , Uusküla Anneli 
Published: November 2022

Background
Post-acute COVID-19 sequelae refers to a variety of health complications involving different organ systems that have been described among individuals after acute phase of illness. Data from unselected population groups with long-time follow up is needed to comprehensively describe the full spectrum of post-acute COVID-19 complications.

Methods
In this retrospective nationwide cohort study, we used data obtained from electronic health record database. Our primary cohort were adults hospitalized with confirmed COVID-19 and matched (age, sex, Charlson Comorbidity Index) unaffected controls from general population. Individuals included from February 2020 until March 2021 were followed up for 12 months. We estimated risks of all-cause mortality, readmission and incidence of 16 clinical sequelae after acute COVID-19 phase. Using a frailty Cox model, we compared incidences of outcomes in two cohorts.

Results
The cohort comprised 3949 patients older than 18 years who were alive 30 days after COVID-19 hospital admission and 15511 controls. Among cases 40.3% developed at least one incident clinical sequelae after the acute phase of SARS-CoV-2 infection, which was two times higher than in general population group. We report substantially higher risk of all-cause mortality (adjusted hazard ratio (aHR) = 2.57 (95%CI 2.23–2.96) and hospital readmission aHR = 1.73 (95%CI 1.58–1.90) among hospitalized COVID-19 patients. We found that the risks for new clinical sequalae were significantly higher in COVID-19 patients than their controls, especially for dementia aHR = 4.50 (95% CI 2.35–8.64), chronic lower respiratory disease aHR = 4.39 (95% CI 3.09–6.22), liver disease aHR 4.20 (95% CI 2.01–8.77) and other (than ischemic) forms of heart diseases aHR = 3.39 (95%CI 2.58–4.44).

Conclusion
Our results provide evidence that the post-acute COVID-19 morbidity within the first year after COVID-19 hospitalization is substantial. Risks of all-cause mortality, hospitalisation and majority of clinical sequelae were significantly higher in hospitalized COVID-19 patients than in general population controls and warrant targeted prevention efforts.
Twining’s Tower and the Challenges of Making Law a Humanistic Discipline
Authors: Sugarman David 
Published: November 2022

This article provides a survey of the life and scholarship of William Twining, focusing largely on his contribution to the broadening of legal education and scholarship. Part I reviews his background, personality and education, then explores the significance of Africa and his anti-colonialism, the inspiration of American legal realism, his teaching in Africa, Belfast, Warwick and UCL, his law reform efforts and his scholarly output. Part II examines his intellectual hallmarks and his struggle to recast law as a humanistic discipline. Part III considers the current efficacy of the notion of law as a humanistic discipline with law schools as purveyors of humanistic education.
Keywords: William Twining; legal education; legal biography; intellectual history; colonialism; postcolonialism.
Rutland Revisited
Authors: Vaughan Steven 
Published: November 2022

This paper explores the multiple and multifaceted relationships between the legal academy and the legal profession in England and Wales. It does so by mirroring the approach of William Twining in his ‘Visit to Rutland’ in Blackstone’s Tower. In drawing on hypothetical happenings in two fictitious law schools and a fictitious law firm, the paper offers commentary on the many points of contact between lawyers and scholars. What is made clear is that these interfaces are often ad hoc and that the legal academy acts as if it needs the profession more than the profession needs it. This may well be the case. What we see then is the modern-day Blackstone’s Tower in the shadow of Cravath’s mansion.
Keywords: legal profession; legal education; Qualifying Law Degree; Solicitors Qualifying Examination; ‘core’ subjects; diversity; Blackstone’s Tower.
Ethical Limits of Pandemic Governance
Authors: Canefe Nergis 
Published: November 2022

This article explores the context-bound qualities of the legally sanctified practices of ‘quarantine’ and border closures as it examines the normalized invisibility of populations on the move who have not been ‘protected’ through the use of such standard Covid-19 measures. Inside national borders, isolation and quarantine orders are traditionally issued by states in accordance with the state’s broad powers to protect public health. Throughout the Covid-19 pandemic, these orders have been either not applied to or on certain occasions intervened with or suspended when a quarantine was deemed unreasonable or inapplicable with reference to migrants, refugees and displaced people. The article proposes a redefinition of death as ‘death-in-living’ and ‘grievable lives’ as ‘disposable lives’ in order to understand the conundrum concerning the selective application of Covid-19 measures to irregular migrants, refugees, undocumented and non-status peoples and stateless communities. Legal responses to the pandemic continue to have a far greater impact upon populations on the move, displaced communities and refugees in radically unequal ways. The article reveals the ethical limitations of global pandemic governance in terms of how legal and policy-based practices systemically fail and desert certain populations and advances a notion of justice that starts from a deeper understanding of existing injustices.
Keywords: global governance; death-in-living; grievable lives; populations on the move; Covid-19 pandemic; ethical limits of law.
MAPEAMENTO GEOMORFOLÓGICO DE DETALHE - UMA PROPOSTA DE ASSOCIAÇÃO ENTRE O MAPEAMENTO TRADICIONAL E AS NOVAS TÉCNICAS EM GEOPROCESSAMENTO
Authors: Rodrigues Sílvio Carlos , Brito Jorge Luís Silva 
Published: November 2022

This paper presents the results of the mixed techniques of traditional
geomorphological cartography, in special an interpretation of stereo pairs and
geoprocessing techniques, using Spring Software. This technique permits a more quickness
in elaboration