bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Neo-Calvinistic Barth Interpretation in Sinophone Scholarship: Its Significance for Sino-Christian Theology
Authors: Tseng Shao Kai 
Published: November 2022

Abstract
Theology and philosophy are strange bedfellows: although they share many similar interests and constantly influence each other, their relationship is fraught with suspicion or even enmity. This problem is especially acute for those who want to harmonize their commitment to sola Scriptura with the use of philosophy in their theology. Drawing insights from Herman Bavinck’s Neo-Calvinist worldview, I argue that this apparent competition is mainly caused by the failure to recognize the organic unity between both disciplines. Without theology, all disciplines would be meaningless, but without philosophy, all disciplines would be unintelligible. Portraying the harmony between theology and philosophy depends on the success of locating the difference and relationship between the universality of theology and that of philosophy. Further, the organicity that suffuses all things and affirms the primacy of special revelation reflects the Neo-Calvinist belief in both sola scriptura and the sacredness of all vocations.
Uncovering Core Dimensions of K-12 Integrated STEM
Authors: Roehrig Gillian H. , Rouleau Mark D. , Dare Emily A. , Ring-Whalen Elizabeth 
Published: November 2022

Abstract
To address the lack of a classroom observation protocol aligned with integrated STEM, the author team developed one to measure the degree of integrated STEM instruction implemented in K-12 science and engineering classrooms. This study demonstrates how our instrument can be used to uncover the dimensions of integrated STEM instruction practiced in K-12 classrooms and to determine which protocol items are associated with each of these dimensions. This article reports on the results of a principal component analysis (PCA) using 2030 K-12 classroom observation videos. PCA revealed two core dimensions of integrated STEM education. Real-world problem-solving includes 21st century skills and STEM practices necessary for developing solutions to real-world problems. Nature of Integrated STEM includes items that promote integration between the real-world context, students’ personal experiences, STEM careers, and STEM content. The authors’ analysis also suggests the possibility of an additional dimension of integrated STEM involving technology practices in STEM.
Otolaryngology Patient Satisfaction with In-Office Appointments and Virtual Visits Due to COVID-19
Authors: Arrighi-Allisan Annie E. , Wong Anni , Gidumal Sunder , Shah Janki , Filip Peter , Omorogbe Aisosa , Rosenberg Joshua , Govindaraj Satish , Iloreta Alfred-Marc 
Published: November 2022

Background: The COVID-19 pandemic forced otolaryngologists to seek new methods of providing patient care in a remote setting. The effect of this paradigm shift on patient satisfaction, however, remains unelucidated. This study compares patient satisfaction with telehealth visits during the COVID-19 pandemic to that with in-office visits during the same period in 2019. Methods: Press Ganey survey responses of patients seen by otolaryngologists within a large, academic, multicenter hospital system were gathered. Responses were included in analyses if they corresponded with a visit that occurred either in clinic March to December 2019 or via telehealth March to December 2020. Chi-Square Test of Independence and Fisher’s Exact Test were employed to detect differences between years. Binary logistic regressions were performed to detect the factors most predictive of positive telehealth experiences. Results: Patient overall satisfaction with in-office and telehealth visits did not differ significantly (76.4% in 2019 vs 78.0% in 2020 rated visit overall as “very good,” P = .09). Patients seen by a Head and Neck (odds ratio 4.13, 95% confidence interval 1.52-11.26, P = .005), Laryngology (OR 5.96, 95% CI 1.51-23.50, P = .01), or Rhinology (OR 4.02, 95% CI 1.55-10.43, P = .004) provider were significantly more likely to report a positive telehealth experience. Conclusions: Patients seen via telehealth during COVID-19 reported levels of satisfaction similar to those seen in-office the year prior. These telehealth satisfaction levels, however, are contextualized within the expected confines of a pandemic. Further research is required to determine whether satisfaction remains consistent as telemedicine becomes a ubiquitous component of medical practice.
Radiation-Induced Laryngeal Mucous Membrane Pemphigoid
Authors: Syal Amit , Lott David G. , Karle William E. 
Published: November 2022

Objectives: Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT. Methods: The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia. Results: This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention. Conclusion: This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential. Level of evidence: Level 4.
Clinical Presentation and Outcome of Sinonasal Extraosseous Plasmacytoma in Denmark: A Nationwide Cohort From 1980 to 2017
Authors: Eriksen Patrick René Gerhard , Khakbaz Elham , Clasen-Linde Erik , Brown Peter de Nully , Haunstrup Laura , Christoffersen Mette , Asdahl Peter , Thomsen Troels Møller , Gerner-Rasmussen Jonas , Heegaard Steffen , von Buchwald Christian 
Published: November 2022

Objectives: Extraosseous plasmacytoma (EOP) is a rare plasma cell neoplasm that tends to convert to plasma cell myeloma (PCM) in about 11% to 35% of cases. It has a predilection for the upper respiratory tract, prototypically affecting the nasal cavity and paranasal sinuses. Contemporary first-line treatment is radiotherapy, with more recent studies showing an added benefit of combining radiation with surgery. In this cohort study, we aimed to examine clinical presentation, treatment, and prognosis for all patients nationwide from 1980 through 2017. Furthermore, we determined the size and extension of tumors, investigating the rate at which minimally invasive surgery would have been possible. Methods: Patients were found in the national pathology registry, and all biopsies were collected for pathology review by a hematopathologist. We performed survival statistics for overall survival (OS), progression-free survival (PFS), and the cumulative incidence of conversion to PCM. Results: Twenty-three patients were included. The median age was 65, and patients were primarily men (78%). Tumors were located in either the nasal cavity (57%), maxillary sinus (39%), or sphenoid sinus (4%). In most cases, the tumor was <5 cm (65%) without extension to adjacent structures (60%). The national incidence was 0.02/100,000 person-years, the median symptom duration until diagnosis was 5 months, and none of the patients presented with contiguous spread to regional lymph nodes. Stand-alone radiotherapy was the predominant treatment (61%). In the entire cohort, one patient died from the initial disease, and six patients died from either relapse of EOP or PCM. The 5-year OS, PFS, and conversion rate to PCM were 78%, 56%, and 23%, respectively. Conclusion: SN-EOP responds well to radiotherapy, but relapse and conversion to PCM were not uncommon and entailed a poor prognosis. Most tumors were endoscopically resectable and non-invasive, making the majority of tumors suitable for surgery as an addition to radiation.
De Novo Seizures, Obsessive Compulsive Symptoms and Neutropenias in Patients on Clozapine: A Retrospective Cohort Study
Authors: Chichra Abhinav , Varughese Niji Rachel , Innamuri Raviteja 
Published: November 2022

Background: Clozapine has well-documented inter-ethnic variations in pharmacokinetics. There is a paucity of data about clozapine use and associated adverse events such as seizures, obsessive compulsive symptoms, neutropenia, and agranulocytosis, from India. Methods: This retrospective cohort study followed up 228 patients initiated on clozapine in a tertiary care referral center in India for an average of 10 years. We calculated incidence rates of new-onset seizures, new-onset obsessive compulsive symptoms, agranulocytosis, and neutropenia. We collected data on doses of clozapine used and serum assays and calculated concentration-to-dose (C/D) ratios. We also collected relevant clinical details about clozapine-induced seizures. Results: In the sample, 16.8% had new-onset seizures, 12.3% had new-onset OC symptoms, 2.7% had neutropenia, and 0.9% had agranulocytosis. The mean C/D ratio was 2.09 (SD = 1.8). Almost half (46.3%) of available serum assays were in the supra-therapeutic range. Seizures were associated with a higher clozapine dose at one year (OR = 1.003; 95%CI = 1.000–1.006; P value = 0.045) and the presence of positive psychotic symptoms at one year (OR = 4.214; 95%CI = 1.894–9.373; P < 0.001). Conclusion: Compared to existing literature, Indians have a higher rate of clozapine- related seizures and need lower doses to reach therapeutic serum levels.
Views of inpatients on the prevention of venous thrombosis with ankle pump exercise: A cross-sectional survey
Authors: Liu Yujie , Wang Fang , Ma Danfeng , Wu Xuejun , Hui Zhen , Zhang Haiyan , Zhang Li 
Published: November 2022

Introduction This study investigated the current status of patients' knowledge and clinical compliance with ankle pump exercises in order to better enhance patient education and improve patient compliance with ankle pump exercises. Methods A cross-sectional survey of the current status of ankle pump exercise awareness and compliance was conducted using a self-designed questionnaire. The questionnaire consisted of a general demographic information questionnaire, a questionnaire on patients’ perceptions of ankle pump exercise and a compliance questionnaire. Results A total of 2,203 patients from 53 clinical departments participated in this survey. 87.8% of patients considered ankle pump exercise important, 92.1% could grasp the knowledge of ankle pump exercise, 48.5% could self-monitor and exercise daily as instructed, 81.5% of health care workers would often supervise patients to complete ankle pump exercise, poor self-control (34.6%), lack of physical strength (21.1%) and perceived hassle (18.9%) were the top 3 factors contributing to patients' inability to complete the ankle pump exercise. Regression analysis showed that the factors influencing patients' compliance with the ankle pump exercise were literacy, economic level, number of comorbidities and caprini risk class ( p < .05). Conclusion The patient’s cognition of ankle pump exercise is good, but the compliance needs to be improved. It is suggested that the compliance of ankle pump exercise in hospitalized patients should be improved in the future to reduce the incidence of Venous thromboembolism.
Clinical results of polidocanol sclerotherapy in venous malformation treatment: Patient-perceived improvement and satisfaction
Authors: Çay Ferdi , Altunbulak Ahmet Y , Özbay Yakup , Eldem Gonca , Çil Barbaros E , Vargel İbrahim , Kutluk Mustafa T , Yalçın Bilgehan , Peynircioğlu Bora 
Published: November 2022

Purpose This study evaluated the results of polidocanol sclerotherapy in the treatment of venous malformations (VM) including patient satisfaction, perceived improvement, and predictors of satisfaction. Material and Method Patients with VM that underwent polidocanol foam sclerotherapy between June 2013 and July 2021 in a single center were retrospectively evaluated. Patient demographics, VM, and treatment characteristics were analyzed. Patient-reported outcomes and satisfaction were analyzed with a questionnaire. Results This study included 232 (136, 58.6%, female) patients. The mean age was 24.49 ± 12.45 years (range 3–72). The clinical response rate was 82.3%. The rate of satisfaction was 82.3%, and 116 (50%) patients were significantly satisfied. There were no major complications. Clinical response and VM margin were related to satisfaction ( p < 0.01, p = 0.012, respectively). Clinical response to pretreatment swelling was related to significant satisfaction ( p = 0.02). Conclusion Polidocanol sclerotherapy was safe and effective in VM treatment with high satisfaction and low complication rates.
Understanding the role and deployment of volunteers within specialist palliative care services and organisations as they have adjusted to the COVID-19 pandemic: A multi-national EAPC volunteer taskforce survey
Authors: Walshe Catherine , Pawłowski Leszek , Shedel Sophie , Vanderstichelen Steven , Bloomer Melissa J , Goossensen Anne , Limonero Joaquín T , Stoelen Karen Sangild , Caraffa Chiara , Pelttari Leena , Scott Ros 
Published: November 2022

Background: Early indications were of a major decline in specialist palliative care volunteer numbers during COVID-19. It is important that ongoing deployment and role of volunteers is understood, given the dependence of many palliative care services on volunteers for quality care provision. Aim: To understand the roles and deployment of volunteers in specialist palliative care services as they have adjusted to the impact of COVID-19. Design: Observational multi-national study, using a cross-sectional online survey with closed and free-text option questions. Disseminated via social media, palliative care networks and key collaborators from May to July 2021. Setting/participants: Any specialist palliative care setting in any country, including hospices, day hospices, hospital based or community teams. The person responsible for managing the deployment of volunteers was invited to complete the survey. Results: Valid responses were received from 304 organisations (35 countries, 80.3% Europe). Most cared for adults only (60.9%), provided in-patient care (62.2%) and were non-profit (62.5%). 47.0% had cared for people with COVID-19. 47.7% changed the way they deployed volunteers; the mean number of active volunteers dropped from 203 per organisation to 33, and 70.7% reported a decrease in volunteers in direct patient/family facing roles. There was a shift to younger volunteers. 50.6% said this drop impacted care provision, increasing staff workload and pressure, decreasing patient support, and increasing patient isolation and loneliness. Conclusion: The sustained reduction in volunteer deployment has impacted the provision of specialist palliative care. Urgent consideration must be given to the future of volunteering including virtual modes of delivery, micro-volunteering, and appealing to a younger demographic.
Serious health-related suffering experienced by children with disability and their families living in Bangladesh: A scoping review
Authors: Smith Suzanne E , Chowdhury Mostofa Kamal , Doherty Megan , Morgan Deidre D 
Published: November 2022

Background: In 2020, the International Association for Hospice and Palliative Care redefined palliative care to incorporate the concept of serious health-related suffering. An estimated 21 million children globally live with conditions which would benefit from a palliative approach to relieve suffering. Bangladesh is a lower-middle income country with isolated provision of palliative care. Aim: To synthesise existing evidence describing serious health-related suffering of children with disability and their families living in Bangladesh and the intersection between this suffering, palliative care and rehabilitation. Design: Scoping review methodology. Data sources: A search strategy related to serious health-related suffering and childhood disability was applied to online databases and grey literature. English language studies (1990–2021) were included. Papers pertaining to serious health-related suffering of typically developing children and those over eighteen years were excluded. Data which addressed the three domains of serious health-related suffering (physical, social and emotional/spiritual) were extracted. Palliative care interventions were assessed with a pre-existing checklist. Results: Forty-six studies were included, representing ten different methodologies. Sample sizes ranged from 11 to 2582 participants, with 87% of studies including children with cerebral palsy. Serious health-related suffering was described in 100% of the studies, only 14 of the studies described specific interventions to mitigate suffering. Convergence between palliative care and rehabilitation approaches was evident. Conclusion: Findings document the extensive nature and burden of serious childhood health-related suffering that may be remediated by a palliative approach. They highlight the urgent need to prioritise service development and research in this area.
Risk factors analysis and risk assessment model construction of systemic lupus erythematosus patients with infection
Authors: Zhang Jiaqian , Zhang Shengxiao , Qiao Jun , Qiu Mengting , Li Xiaofeng 
Published: November 2022

Objective To analyze the characteristics of peripheral blood lymphocyte subsets in systemic lupus erythematosus (SLE) patients with infection and non-infection group. Explore the risk factors of infection in SLE patients and establish a risk matrix model to predict the occurrence of co-infection. Methods total of 333 SLE patients without infection, 163 patients suffering from infection, and 132 healthy controls (HCs) were recruited. General clinical data and disease activity indicators were collected. The levels of total T, B, CD4+T, CD8+T, NK, Th1, Th2, Th17, and Treg cells in peripheral blood of HCs, SLE patients (including infected and non-infected group) were analyzed by flow cytometry. The risk assessment model was constructed, and the receiver operating characteristic curve was drawn. 39 SLE patients with infection and 20 patients without infection were randomly selected to evaluate the predictive power of the regression model. Results The levels of T, B, CD4+T, CD8+T, and NK cells in the infected patients were significantly decreased when compared with that of both non-infected patients and HCs ( p < .05). The non-infected patients had a higher level of Th17 than that of HCs ( p < . 05), but the absolute numbers of Th17 in infected patients was the lowest among the three groups ( p < .001). The number of Treg cells in SLE patients was significantly lower than that of HCs ( p < .01), and the infected patients had the fewest Treg cells among all these groups ( p < . 05). A risk assessment model for SLE with infection was established, p = 1/(1−e−y), Y = 1.763-0.004 × Absolute number of CD4 + T cells-0.005 × Absolute number of NK cells −0.005 × Platelet count(×1012/L) + 1.033 × Absolute number of lymphocytes (×109/L) + 0.023 × C-reactive protein (mg/dL), whose predictive sensitivity is 77.5%, and specificity is 78.3%. Conclusion The new risk assessment model exhibits good predictive ability to assess co-infection risk in SLE patients. T cells, NK cells, and CD4 + T cells along with other parameters help in differentiating Lupus with infection from Lupus alone.
Investors’ Preference for Creating Impact: (A study to understand impact investors’ preference while making investment in India)
Authors: Rathee Prerna , Aggarwal Shalini 
Published: November 2022

Purpose: The main aim of this article is to analyse the preference of impact investors when it comes to the selection of ventures for investment. The study has been conducted with the sole objective of trying to evaluate the choices of impact investors in the Indian market. In addition to this, the present study strives to find out how a certain venture turns out to be the most preferred area of investment and what instrument is preferred to invest in for impact investments, and the criteria that guide investors to arrive at their choice of investment portfolios in Indian impact investment market. Design/Methodology/Approach: A choice-based conjoint experiment has been done in which respondents have to rank the different options which were generated by orthogonal arrays based on their preference. The preference function was computed by using OLS regression. Findings: It has been revealed through this study that while deciding to invest for impact, first preference is accorded to stage of investment in terms of highest importance value which was ensued by their behavioural penchant to do impact investment. Impact investors are inclined to invest in social ventures having the most innovative ideas in response to addressing social problems. The most preferred area of investment is the healthcare sector which is ensued by agriculture and education. Research Limitations: The real behaviour of an individual cannot be predicted through an online survey, which restricts the generalization of the study. Practical Implications: This study presents a simple yet empirical tool that will undoubtedly aid social entrepreneurs, impact investors and other investors to understand the leanings of impact investors and allows them to understand in a better way, how investors’ behaviour differs while making investment decisions in India. The ﬁndings will also help policymakers to create a more conducive environment for impact investing in India. Originality/Value: The article is unique in the sense that it endeavours to analyse the impact investors’ preferences and choices with the application of conjoint analysis in the Indian perspective.
Incidence and Prognosis Nomogram of Small Solitary Lung Cancer (≤2 cm) With Extra-Thoracic Metastasis at Initial Diagnosis:A Population-Based Study
Authors: Hu Ao’ran , Chen Zui , Liu Chaoyuan , Gao Yuan , Deng Chao , Liu Xianling 
Published: November 2022

Background Small solitary lung cancer (≤2 cm) with extra-thoracic metastasis and no nodal metastasis or intra-thoracic metastasis is a rare situation in clinic. Methods Lung cancer patients with stage T1aN0M0 and T1aN0M1b from 2010 to 2015 were identified from the Surveillance, Epidemiology, and End Results database. The identified significant parameters were utilized to develop 2 nomogram to predict the extra-thoracic metastasis rates and the overall survival for the group of patients with stage T1aN0M1b. Results Small solitary lung cancers which occur in the males, younger patients, or locate in the main bronchus or left lung, or with histologic type as small cell lung cancer, or with undifferentiated type, tend to have extra-thoracic metastasis. Application of the nomogram in the intra-group still gave good discrimination and good calibration. Univariable and multivariable analysis identified several clinical data as the prognostic factors for lung cancer patients with stage T1aN0M1b, all the factors above were incorporated into the nomogram. ROC curve analysis showed that the nomogram had good discrimination, with AUC of .779, .786 and .77 for 1-, 3- and 5-year survival in the development group and validation group, respectively. Moreover, decision curve analysis has been implemented to evaluate and compare prediction and prognostic nomogram. Conclusions Younger male patients whose lung cancer locates in main bronchus or left lung, or with undifferentiated type, or with histologic type as small cell lung cancer are more likely to have extra-thoracic metastasis. The proposed nomogram reliably predicted OS for lung cancer patients with stage T1aN0M1b, though further validation is needed, it may be a useful tool in clinical practice. These models can be wildly used for easy facilitate the lung cancer individualized prediction of extra-thoracic metastasis and OS.