bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of depression, anxiety and associated factors among adults with living human immunodeficiency virus in University Malaya Medical Centre
Authors: Ong Jen Yeung , Yee Anne , Amer Nordin Amer Siddiq , Danaee Mahmoud , Azwa Raja Iskandar 
Published: July 2022

Background This study estimates prevalence of depression and anxiety among adults living with Human Immunodeficiency Virus (HIV) in University Malaya Medical Centre (UMMC) and determines its associated factors. Methods This cross-sectional study was conducted between August 2020 and January 2021, in the Infectious Disease clinic and ward. One hundred ninety-one patients were recruited via convenience sampling. Patients’ sociodemographic were obtained, followed by Depression, Anxiety, Stress Scale -21 (DASS-21), Multidimensional Scale of Perceived Social Support (MSPSS), and M.I.N.I. international neuropsychiatric interview (M.I.N.I.) The cut off DASS-21 point for depression is ≥5, for anxiety, ≥ 4. Mann-Whitney U and Chi square test were used to analyse the association between variables, and logistic regression to find predictability. Results Of the 191 participants, 89.5% outpatient, mean age 40 years (SD 0.742), 91.1% male, 65.4% single, 71.2% working, 46.1% Malaysian Chinese, 59.8% non- heterosexual, mean 6 years of being HIV positive; mean CD4 count 449/μL; mean viral load 116,690 (median = 20). 85.9% were taking antiretroviral therapy. The prevalence of depression was 35.1% ( n = 67); anxiety was 42.9% ( n = 82). Regression analysis revealed anxiety and stress increased odds of depression by 3.8 times ( p = .001) and 12 times ( p < .001) respectively. Those 40 years old and younger had 2.3 times odds of anxiety ( p = .048). Increased social support from friends increased odds of anxiety by 1.7 times ( p = .018). Depression and stress increased odds of anxiety by 4.4 times ( p = .001) and 3.7 times ( p = .008) respectively. Conclusions Depression and anxiety among people with HIV is often under-recognised. Early identification and treatment of the mental illness is warranted. Screening with DASS-21 is useful to detect depression in patients with HIV.
Safety and tolerability of bone marrow–derived mesenchymal stem cells in lupus animal models and a phase I clinical trial in humans
Authors: Chun Sehwan , Choi Chan-Bum , Kim Min S. , Nam Jae-Yong , Lee Tae Y. , Lee Young-Tae , Kim SungHoon , Han Sang-Bae , Bae Sang-Cheol 
Published: July 2022

Objective Several clinical trials aimed at treating various autoimmune diseases, including systemic lupus erythematosus (SLE), by introducing mesenchymal stem cells (MSCs) have been conducted. However, with refractory lupus nephritis (LN), the outcomes of MSC transplantation are not well known, and further validation is required. In particular, data concerning the safety and efficacy of LN treatment using bone marrow-derived MSCs (BM-MSCs) are still lacking. Methods We identified characteristics of BM-MSCs in terms of cell morphology, chromosomal stability, differentiation capacity, and phenotype through cell passages. The in vivo stability of BM-MSCs was evaluated by single-dose and repeated-dose toxicity tests, tumorigenicity tests, and biodistribution tests using lupus mouse models. Based on the encouraging nonclinical results, we conducted a nonrandomized, open-label, single-arm phase I clinical trial to evaluate the tolerability and safety of a single administration of haploidentical allogeneic BM-MSCs (CS20AT04) in seven LN patients (NCT03174587). We used a classical three + three design to find the optimal dosage. The starting dose was 2.0×106 cells/kg and escalated to 3.0×106 cells/kg if there was no dose-limiting toxicity (DLT). Evaluation of the safety and tolerability was assessed 28 days after the infusion, and the maximum tolerated dose was determined. Results Properly cultured BM-MSCs showed high proliferation and multipotency, but chromosomal changes were not found. There were two deaths by a rapid administration rate in the high-dose group (2.0×106 cells/head) in a single administration test. BM-MSCs were distributed in the kidneys until Day 7. In the phase I clinical trial, seven LN patients were enrolled. Participants received BM-MSCs through intravenous infusion. There was no DLT at both initial dose (2.0×106 cells/kg) and escalated dose (3.0×106 cells/kg). One patient was not administered the full 2.0×106 cells/kg dose because of a technical error during infusion. This patient did not show DLT. Three adverse events were reported, namely, one diarrhea, one toothache, and one arthralgia, and all were considered NCI-CTC grade I events. Conclusion We defined the characteristics of BM-MSCs and identified their safety and tolerability in both animal models and a phase I clinical trial. The maximum tolerated dose was determined to be 3.0×106 cells/kg in patients with LN.
Overexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
Authors: Ma Wei , Liao Yiqun , Gao Ziwen , Zhu Wenyan , Liu Jianbing , She Wandong 
Published: July 2022

Background: LIMA1 encodes LIM domain and actin binding 1, a cytoskeleton-associated protein whose loss has been linked to migration and invasion behavior of cancer cells. However, the roles of LIMA1 underlying the malignant behavior of tumors in head and neck squamous cell carcinoma (HNSC) are not fully understood. Methods: We conducted a multi-omics study on the role of LIMA1 in HNSC based on The Cancer Genome Atlas data. Subsequent in vitro experiments were performed to validate the results of bioinformatic analysis. We first identified the correlation between LIMA1 and tumor cell functional states according to single-cell sequencing data in HNSC. The potential downstream effects of LIMA1 were explored for gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways through functional enrichment analysis of the gene sets that correlated with LIMA1 in HNSC. The prognostic role of LIMA1 was assessed using the log rank test to compare difference in survival between LIMA1High and LIMA1Low patients. Univariate Cox regression and multivariate Cox regression were further carried out to identify the prognostic value of LIMA1 in HNSC. Results: LIMA1 was identified as a prognostic biomarker and is associated with epithelial-mesenchymal transition (EMT) progress in HNSC. In vitro silencing of LIMA1 suppressed EMT and related pathways in HNSC. Conclusions: LIMA1 promotes EMT and further leads to tumor invasion and metastasis. Increased expression of LIMA1 indicates poor survival, identifying it as a prognostic biomarker in HNSC.
A Chief Operating Officer's Perspective on Managerial Coaching
Authors: Carvalho Charles , Carvalho Sheldon , Carvalho Fallan Kirby 
Published: July 2022

The Problem In recent years, managerial coaching has garnered increasing attention from organizations, even though practitioners suggest that managers may resist coaching employees. More dialog and research that uncovers the motivations, challenges, and benefits managers accrue from coaching, and the crucial role line and human resource development (HRD) managers can play in creating coaching cultures seems warranted. The Solution Perspectives on actions that HRD practitioners can take to support managerial coaching are gained from an interview with a global organization executive. The Stakeholders This article will benefit HRD practitioners and line managers seeking to institutionalize a culture of coaching.
Radiobiological Comparison of Acuros External Beam and Anisotropic Analytical Algorithm on Esophageal Carcinoma Radiotherapy Treatment Plans
Authors: Wang Lin , Zhang Jianping , Huang Miaoyun , Xu Benhua , Li Xiaobo 
Published: July 2022

Objective The present study aimed to investigate the dose differences and radiobiological assessment between Anisotropic Analytical Algorithm (AAA) and Acuros External Beam (AXB) with its 2 calculation models, namely, dose-to-water (AXB-Dw) and dose-to-medium (AXB-Dm), on esophageal carcinoma radiotherapy treatment plans. Materials and methods The AXB-Dw and AXB-Dm plans were generated by recalculating the initial 66 AAA plans using the AXB algorithm with the same monitor units and beam parameters as those in the original plan. The dosimetric and radiobiological assessment parameters were calculated for the planning target volume (PTV) and organs at risk (OARs). The gamma agreement for the PTV and the correlation between it and the volume of the air cavity and bone among the different algorithms were compared simultaneously. The dose discrepancy between the theoretical calculation and treatment planning system (TPS) when switching from AXB-Dm to AXB-Dw was analyzed according to the composition of the structures. Results The PTV dose of AXB-Dm plans was significantly smaller than that of the AAA and AXB-Dw plans (P < .05), except for D2. The difference values for AAA vs AXB-Dm (∆ Dx,(AAA-AXB,Dm)) and AXB-Dw vs AXB-Dm (∆ Dx,(AXB,Dw-AXB,Dm)) were 1.94% [1.27%, 2.64%] and 1.95% [1.56%, 2.27%], respectively. For the spinal cord and heart, there were obvious differences between the AAA vs AXB-Dm (spinal cord: 1.15%, heart: 2.89%) and AXB-Dw vs AXB-Dm (spinal cord: 1.88%, heart: 3.25%) plans. For the lung, the differences between AAA vs AXB-Dm and AAA vs AXB-Dw were significantly larger than those of AXB-Dm vs AXB-Dw. Compared to the case of AAA and AXB-Dw, the decrease in biologically effective dose (BED10, [Formula: see text]) of AXB-Dm due to dose non-uniformity exceeded 6.5%, even for a small [Formula: see text]. The average values of equivalent uniform dose in the AAA, AXB-Dw, and AXB-Dm plans were 52.03±.39 Gy, 52.24 ± .81 Gy, and 51.13 ± .47 Gy, respectively. The tumor control probability (TCP) results for PTV in the AAA, AXB-Dw, and AXB-Dm plans were 62.29 ± 1.57%, 62.82 ± 1.69%, and 58.68±1.88%, respectively. With the 2%/2 mm and 3%/3 mm acceptance criteria, the mean values of [Formula: see text], [Formula: see text], and [Formula: see text] were 87.24, 63.3, and 64.81% vs 97.86, 91.77, and 89.25%, respectively. The dose discrepancy between the theoretical calculation and TPS when switching from AXB-Dm to AXB-Dw was approximately 1.63%. Conclusions The AAA and AXB-Dw algorithms overestimated the radiobiological parameters when the tumor particularly consisted of nonuniform tissues. A relatively small dose difference could cause a significant reduction in the corresponding TCP. Dose distribution algorithms should be carefully chosen by physicists and oncologists to improve tumor control, as well as to optimize OARs protection.
Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion
Authors: Javed Areeba , Muzammal Ayman , Akash Muhammad Sajid Hamid , Rehman Kanwal 
Published: July 2022

This study was aimed to investigate the therapeutic potentials of plant-based bioactive compounds; lutein and resveratrol alone and/or in combination with DPP-4 enzyme inhibitor; sitagliptin on the secretion and bioavailability of Glucagon like peptide-1(GLP). For this, experimental rats were divided into seven groups. Group 1 was marked as control, while other six groups received streptozotocin (60 mg/kg I.P.). Later, group 2 was kept disease-control. While group 3 received 10 mg/kg/day sitagliptin (DDP-4i). Group 4 received 40 mg/kg/day lutein (LUT) and group 5 received 30 mg/kg/day resveratrol (RES). While group 6 and 7 were received combination of DPP-4i+LUT and DPP-4i+RES, respectively. Combined administration of DPP-4i+LUT or DPP-4i+RES showed expected therapeutic effects by lowering the fasting blood glucose and maintaining the serum insulin concentrations with improved glucose sensitivity and reduced insulin resistance. Further, co-administration of LUT and RES with DPP-4i revealed beneficial effects on measures of insulin resistance, circulating lipids, glycemic index, oxidative stress, and inflammatory status along with restoration of histological morphology of pancreatic cells and enterocytes that seemed to improve the level of GLP-1. Hence, substantial verdicts of this study showing therapeutic potentials of LUT and RES would surely help to recognize the potential effects in combination with DPP-4i as stimulators of GLP-1 secretion.
The effect of stress levels of nurses on performance during the COVID-19 pandemic: the mediating role of motivation
Authors: Ardıç Mesut , Ünal Özgün , Türktemiz Halil 
Published: July 2022

Background During the COVID-19 pandemic, it is thought that nurses working at more intensive levels and in high-risk areas may increase their stress and decrease their motivations and performance. Aims This study aimed to determine the effects of stress and work stress on nurses’ motivations and performances. Methods An online, cross-sectional survey, which used self-assessment scales to measure perceived stress, perceived work stress, motivation, and work performance was used as a data collection tool. The target population was all working nurses in a hospital. Results One hundred and fourteen nurses completed the questionnaires. The results of the study show that the participants' perceived motivation level (3.131 ± 0.685), perceived stress level (2.885 ± 0.547), and perceived job stress level (3.202 ± 1.067) were at a medium level, while their perceived performance level (3.845 ± 0.783) was at a high level. According to correlation analyses results, increases in perceived stress levels of nurses decrease their motivations ( r = −0.502) and performances ( r = −0.603). Similarly, increases in perceived work stress levels of nurses decrease their motivations ( r = −0.441) and performances ( r = −0.534). According to the Structural Equation Modelling (SEM) analysis, motivation has a mediating role in the negative effect of perceived stresses on performance ( β = −0.694) and augments such negative effect ( β = −0.169). Similarly, motivation has a mediating role in the negative effect of perceived work stresses on performance ( β = −0.295) and increases the negative effect of perceived work stress on performance ( β = −0.097). Conclusions Nurses’ perceived stress and perceived work stress levels were not high, but an increase in these variables may decrease nurses’ motivation and performance. Thus, controlling nurses’ stress levels and identifying possible stress sources related to the COVID-19 pandemic are important to support nurses in their work.
Nurses’ lived experiences of caring for patients with COVID-19: a phenomenological study
Authors: Heydarikhayat Nastaran , Ghanbarzehi Nezar , Shahkaramzehi Zarkhatoon , Sabagh Kimya , Rohani Camelia 
Published: July 2022

Background COVID-19 is an infectious disease caused by a novel Coronavirus which transmits from person to person throughout the world. This study aimed to explore the lived experiences of nurses’ caring for patients with COVID-2019 in the context of the healthcare system of Iran. Methods This is a phenomenological study with 13 participant nurses (6 men and 7 women) who were caring for COVID-19 patients in one of the university hospitals in Southeast of Iran. Qualitative data were analysed by the seven steps of Colaizzi’s method. Results Participants reported around a five-month history of caring for COVID-19 patients. After analysis, 597 codes, 16 categories, four sub-themes, and one theme were extracted. “Caring from self-sacrifice to avoidance” was the main theme of the study with sub-themes of “Anxiety Chain”, “Manifestation of Humanitarian Caring”, “Ethical Challenges”, and “Challenges of Overcoming Crisis”. Conclusions Nurses explained their caring experiences with patients on a continuum from humanitarian caring and self-sacrifice to caring avoidance. Because of the multi-sources of psychological stress and ethical challenges together with this infection, healthcare managers should plan for holistic regular psychological support services, prevention of job inequalities, and do strategic planning for access to enough resources in the healthcare system.
Impact of Inspiratory Muscle Training on Weaning Parameters in Prolonged Ventilator-Dependent Patients: A Preliminary Study
Authors: Chang Hsiao-Yun , Hsiao Hsiang-Chun , Chang Hwai-Luh 
Published: July 2022

Introduction Patients require prolonged mechanical ventilation to overcome respiratory failure in the chronic respiratory care ward; however, how to facilitate ventilator weaning using a nurse-led strategy is limited. Objectives This study aimed to examine the impact of adjusting ventilator trigger sensitivity as inspiratory muscle training on weaning parameters in patients with prolonged ventilator dependence. Methods Multiple pre-test–post-test with a non-equivalent control group design was conducted at a chronic respiratory care ward in southern Taiwan. A convenience sampling method was used to recruit patients who received prolonged mechanical ventilation for more than 21 days into control ( n  =  20) and intervention groups ( n  =  22). Adjustment of ventilator trigger sensitivity started from 10% of the initial maximum inspiratory pressure and increased to 40% after a training period of six weeks. The weaning parameters were collected for pre-test and multiple post-tests, and statistical analysis of treatment effects was performed using the generalized estimating equation. Results Magnitude of weaning parameters was significantly higher in the intervention group after the six-week training, including maximum inspiratory pressure, rapid shallow breathing index, tidal volume, and ratio of arterial-to-inspired oxygen. Conclusion Adjustment of ventilator trigger sensitivity as inspiratory muscle training can help prolonged ventilator-dependent patients improve their respiratory muscle strength, breathing patterns, and oxygenation.
Identification of all-against-all protein–protein interactions based on deep hash learning
Authors: Jiang Yue , Wang Yuxuan , Shen Lin , Adjeroh Donald A. , Liu Zhidong , Lin Jie 
Published: July 2022

Abstract
Background
Protein–protein interaction (PPI) is vital for life processes, disease treatment, and drug discovery. The computational prediction of PPI is relatively inexpensive and efficient when compared to traditional wet-lab experiments. Given a new protein, one may wish to find whether the protein has any PPI relationship with other existing proteins. Current computational PPI prediction methods usually compare the new protein to existing proteins one by one in a pairwise manner. This is time consuming.

Results
In this work, we propose a more efficient model, called deep hash learning protein-and-protein interaction (DHL-PPI), to predict all-against-all PPI relationships in a database of proteins. First, DHL-PPI encodes a protein sequence into a binary hash code based on deep features extracted from the protein sequences using deep learning techniques. This encoding scheme enables us to turn the PPI discrimination problem into a much simpler searching problem. The binary hash code for a protein sequence can be regarded as a number. Thus, in the pre-screening stage of DHL-PPI, the string matching problem of comparing a protein sequence against a database with M proteins can be transformed into a much more simpler problem: to find a number inside a sorted array of length M. This pre-screening process narrows down the search to a much smaller set of candidate proteins for further confirmation. As a final step, DHL-PPI uses the Hamming distance to verify the final PPI relationship.

Conclusions
The experimental results confirmed that DHL-PPI is feasible and effective. Using a dataset with strictly negative PPI examples of four species, DHL-PPI is shown to be superior or competitive when compared to the other state-of-the-art methods in terms of precision, recall or F1 score. Furthermore, in the prediction stage, the proposed DHL-PPI reduced the time complexity from $$O(M^2)$$

O
(

M
2

)

to $$O(M\log M)$$

O
(
M
log
M
)

for performing an all-against-all PPI prediction for a database with M proteins. With the proposed approach, a protein database can be preprocessed and stored for later search using the proposed encoding scheme. This can provide a more efficient way to cope with the rapidly increasing volume of protein datasets.
Prevalence of cardiovascular diseases and associated factors among adults from southwest Iran: Baseline data from Hoveyzeh Cohort Study
Authors: Saki Nader , Karandish Majid , Cheraghian Bahman , Heybar Habib , Hashemi Seyed Jalal , Azhdari Maryam 
Published: July 2022

Abstract
Background
Cardiovascular diseases (CVDs) were the number one cause of death in Iran. The main risk factors of CVDs include unhealthy lifestyles, insulin resistance, hypertension (HTN), and hyperlipidemia. Given that there are modifiable risk factors for CVDs, this cross-sectional study aimed to evaluate the prevalence of CVDs and their risk factors among adults.

Methods
The present cross-sectional study was conducted on 9828 adults 35–70 years (both sexes). The demographic data, lifestyle habits, anthropometric data, and clinical and biochemical parameters were collected from the baseline data of the Hoveyzeh Cohort Study. The odds ratio (OR) of CVDs was assessed by multivariable logistic regression.

Results
The prevalence of CVDs was higher in females than males (16.2 vs. 12.6, p ≤ 0.001). The prevalence of CVDs was related to age, gender, marital status, lifestyle, anthropometric measurements, cholesterol, high-density lipoprotein, HTN, and fasting plasma glucose (FPG) (p ≤ 0.05). The participants aged 65–70 y showed the highest odds of CVDs (OR: 3.97, 95% CI: (3.14, 5.01), (p ≤ 0.001)). Males (OR: 1.76, 95% CI: (1.51, 2.05), p ≤ 0.001), married status (OR: 1.63, 95% CI: (1.08, 2.47), p = 0.021), more using a mobile phone (OR: 1.26, 95% CI: (1.09, 1.46), p ≤ 0.002), and smoking cigarettes (OR: 1.44, 95% CI: (1.24, 1.68), p ≤ 0.001) associated with CVDs. Higher odds of CVDs were related to low physical activity (PA) (OR: 1.56, 95% CI: (1.34, 1.8), p ≤ 0.001), body mass index > 30 (OR: 1.68, 95% CI: (1.01, 2.8), p ≤ 0.047). Moreover, odds of CVDs were related to systolic blood pressure (SBP) ≥ 140 mm Hg (OR: 1.25, 95% CI: (1.04, 1.51), p = 0.017), FPG = 100–126 mg/dl (OR: 1.24, 95% CI: (1.07, 1.43), p = 0.003), and FPG > 126 mg/dl (OR: 1.71, 95% CI: (1.47, 1. 98), p ≤ 0.001).

Conclusion
The present study showed the main risk factors of CVDs were older age, married status, using a mobile phone, low PA, smoking, obesity, and abnormal FPG and SBP. The lower odds of CVDs were found in the participants with normal cholesterol.