bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Stigma Experience and Self-Perception Related to Facial Appearance in Young Japanese Patients with Cleft lip and/or Palate
Authors: Oka Ayaka , Tanikawa Chihiro , Ohara Hauka , Yamashiro Takashi 
Published: July 2022

Objective To examine the relationship between stigma experience related to facial appearance in Japanese youths with cleft lip and/or palate (CL/P) and their self-perception. Design A cross-sectional study. Participants Sixty-nine Japanese youths with CL/P (11-18 years old) Outcome measures The participants’ stigma experience in relation to facial appearance (measured with 7 single contextual scale items) and their self-perception (measured with 5 domain scores based on 30 perceptual items) were assessed using the Japanese version of the Youth Quality of Life Instrument-Facial Differences Module. Participants were categorized into high and low self-perception subgroups with a threshold of 1 standard deviation for each domain. The frequency of stigma experiences was compared between the following 2 subgroups: age, sex, cleft palate only versus other cleft, and high versus low self-perception. Correlations between the responses regarding stigma and all domain scores were examined. Results Sixteen percent of the participants reported experiencing stigma. Hearing others say something about their face occurred significantly more frequently in youths 15 to 18 years of age than in youths 11 to 14 years of age. Stigma frequency was not found to differ by sex or cleft type. Stigma experiences were significantly more frequent for youth with higher scores across negative self-perception domains as well as higher coping skills. Significant correlations were identified between responses regarding stigma items and all domain scores ( r  =  0.27-0.63, p < .05). Conclusions It was found that stigma experiences related to facial appearance may influence negative self-perceptions of facial differences as well as higher coping skills among Japanese youths with CL/P.
Cellular Indices and Outcome in Patients with Acute Venous Thromboembolism
Authors: Siddiqui Fakiha , García-Ortega Alberto , Kantarcioglu Bulent , Sinacore James , Tafur Alfonso , Demelo-Rodríguez Pablo , Antonio Nieto José , Usandizaga Esther , Fareed Jawed , Monreal Manuel , the RIETE investigators  
Published: July 2022

Background Cellular indices provide integrative information about systemic inflammation status which is readily available from routine laboratory parameters. This study aimed to evaluate the prognostic role of three cellular indices in patients with venous thromboembolism (VTE). Methods The RIETE registry database was used to determine the association between the baseline neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR) and systemic-immune-inflammation-index (SII) for 90-day adverse outcomes in patients with acute VTE. Results From January 2020 to April 2021, 4487 patients with acute VTE were recruited in the RIETE registry. Of these, 2683 presented with symptomatic pulmonary embolism (PE); 283 with incidental PE; 1129 with lower-limb deep vein thrombosis (DVT); 175 with upper-limb DVT; 69 with splanchnic vein thrombosis; 142 with superficial vein thrombosis and 20 with retinal vein thrombosis. Mean values were: NLR 5.9 ± 7.1, PLR 190 ± 158 and SII 1459 ± 2028. During the first 90-days, 38 patients (0.8%) developed recurrent DVT, 45 (1.0%) had recurrent PE, 152 (3.4%) suffered major bleeding, and 484 (11%) died. On multivariable analysis, patients with NLR >4.41 were at an increased risk for major bleeding and patients with NLR >4.96 were at the risk of death, while those with SII >1134.5 were at increased risk for death. Conclusions This study reports the results of a large cohort to date which evaluate the prognostic value of three cellular indices simultaneously in patients with acute VTE. Results support that none of the three baseline cellular indices were sufficient for prediction of VTE recurrences in acute VTE patients. The patients with higher baseline NLR values were at an increased risk of major bleeding or death, those with high SII values were only at an increased risk for mortality.
Validating Embedded Validity Indicators of Feigned ADHD-Associated Cognitive Impairment Using the MOXO-d-CPT
Authors: Winter Daniella , Braw Yoram 
Published: July 2022

Background: The current study aimed to validate the utility of previously established validity indicators derived from MOXO-d-CPT’s continuous performance test. Method: Healthy simulators feigned impairment after searching online for relevant information, an ecologically valid coaching condition ( n = 39). They were compared to ADHD patients ( n = 36) and healthy controls ( n = 38). Results: Simulators performed significantly worse than ADHD patients in all MOXO-d-CPT indices, as well as a scale that integrates their contributions (feigned ADHD scale). Three indices (attention, hyperactivity, and impulsivity) and the latter scale exhibited adequate discriminative capacity. Higher education was associated with an exaggerated impairment among simulators, easing their detection. Conclusion: Similarity between the current study and a previous study which examned the utlity of the MOXO-d-CPT validity indicators, increases our confidence in the efficacy of the latters embedded validity indicators. Though the findings provide initial validation of these validity indicators, generalizing beyond highly functioning participants necessitates further research.
Intravitreal recombinant tPA before vitrectomy for diabetic tractional retinal detachment: A randomized controlled trial
Authors: Falavarjani Khalil Ghasemi , Anvari Pasha , Shad Esrafil , Dehghan Niri Mohammad Hasan , Sedaghat Ahad , Abdi Fatemeh , Parvaresh Mohammad Mehdi , Saeidian Behrouz , Gordiz Arzhang , Amirfarhangi Anbardan Abdollah 
Published: July 2022

Purpose To investigate the effect of intravitreal recombinant tissue plasminogen activator (rt-PA) injection before vitrectomy on surgical facility and outcome in diabetic tractional retinal detachments (TRD). Methods Prospective, randomized, interventional clinical trial. A total of 38 eyes with diabetic TRD were candidates for vitrectomy. Patients were randomized 1:1 to receive intravitreal rt-PA, five to seven days before vitrectomy or no injection. Intraoperative surgical facility and anatomic success at month 3 after surgery were assessed. Results Mean patient age was 54.2 ± 9.4 years. There was no statistically significant difference between rt-PA and no injection groups with regard to anatomic success (89% versus 95%, respectively, P = 0.547) and best corrected visual acuity at 3 months (2.0 versus 2.1 logMAR, respectively, P = 0.840). However, surgical facility score was statistically significantly lower in rt-PA injection group compared to no injection group (4.1 ± 1.7, 5.8 ± 2.0, respectively, P = 0.007). Conclusions Vitrectomy for TRD was easier after preoperative rt-PA injection, without affecting the anatomic and visual outcomes.
Prevention of Bortezomib-Induced Peripheral Neuropathy in Newly Multiple Myeloma Patients Using Nervonic Acid, Curcuma Rizoma, and L-Arginine Compound: A Pilot Study
Authors: Maschio Marta , Maialetti Andrea , Marchesi Francesco , Gumenyuk Svitlana , Pisani Francesco , Papa Elena , Galiè Edvina , Koudriavtseva Tatiana , Graziano Giuliana , Giannarelli Diana , Mengarelli Andrea 
Published: July 2022

Introduction: This is a phase II pilot study to evaluate the efficacy of a nutraceutical compound composed of nervonic acid, curcuma rizoma, and l-Arginine to prevent the onset of bortezomib-induced peripheral neuropathy (BIPN) in 16 newly diagnosed multiple myeloma (MM) patients treated with bortezomib (BTZ) over 6 months. Materials and methods: Assessments included neurological examination and electroneurography, Common Terminology Criteria for Adverse Events (NCI-CTCAE), reduced version of Total Neuropathic Score (TNSr), pain evaluation, functional autonomy scales, self-perceived symptoms and quality of life questionnaires at baseline and after 6 months. Results: No patients were symptomatic at baseline, despite neurophysiological data and TNSr evidence of peripheral neuropathy (PN) in 11 of them. After 6 months, only 9 patients completed the study. All had modifications in neurological examination with 8 out of 9 showing neurophysiological data of PN (2 of which had a NCI-CTCAE grade of neurotoxicity ≥2); 4 patients dropped out due to BIPN, 2 because of MM progression, 1 for scarce compliance. Discussion: In our study, the compound was not adequate to prevent BIPN. The incidence of subclinical PN in MM patients is a risk factor for the development of severe neurotoxicity during BTZ treatment. For this reason to evaluate the efficacy of any preventive compound, as well as to manage MM patients, it should be mandatory to include neurophysiological study as a standard procedure.
The trend and characteristics of China studies published in SSCI public administration journals: A bibliometric analysis
Authors: Wang Daan , Hsieh Chih-Wei 
Published: July 2022

Scholars of China studies have been keen to publish in SSCI journals since mainland Chinese universities started to embrace international academic standards in the early 1990s. The widespread assumption is that publishing in SSCI journals contributes to not only the promising career of an individual scholar but also knowledge accumulation and development in the Chinese public administration field. However, it remains unanswered concerning which topic of China studies is more likely to arouse interest from journal editors and reviewers. As SSCI publications become increasingly desirable yet challenging for Chinese scholars, this study attempts to offer recommendations by exploring the trend and characteristics of China studies published in SSCI public administration journals, which are included in the Web of Science (WoS) database. This study uses bibliometric analysis to conduct a systematic review on 584 articles of China studies published in 47 SSCI public administration journals. It aims to generate various quantitative results, including journal ranking, title and keywords co-occurrences network, citation analysis, co-citation network, co-authorship network, bibliographic coupling network, and so on. In this way, this paper will reveal the latest trend and characteristics of China studies published in SSCI public administration journals. Consequently, it will help scholars enhance the quality and quantity of China studies, advance their chances of success in SSCI public administration journals, and broaden and deepen their contribution to the global academic community.
Exploration of knowledge, attitudes, and perceived benefits towards nurse managers’ participation in the health policy-making process: a qualitative thematic analysis study
Authors: Hajizadeh Alireza , Zamanzadeh Vahid , Khodayari-Zarnaq Rahim 
Published: July 2022

Background Participation of nurse managers in policy-making could help policy-makers to propose relevant and effective policies and support other policy actors involved with these processes. Objective This study aimed at exploring the attitudes and perceived benefits of nurse managers’ participation in the health policy-making process. Methods In this descriptive qualitative research, semi-structured interviews were conducted with 16 nurse managers, government officials, and faculty members. Recruitment was based on purposive sampling from different regions across Iran. A thematic analysis was performed in MAXQDA (version 2012). Results After analysis of the qualitative data, four themes and 13 sub-themes emerged. The themes were feelings about nurse managers’ participation, advantages of nurse managers’ participation, problems due to the non-participation of nurse managers, and recommendations for improvement of the policy-making process. Conclusion The outcomes provided new insights into the perceived benefits of and attitudes towards nurse managers’ participation in health policy making in the Iranian setting. It is crucial to strengthen the capacity for nurse managers' participation in health policy making to develop effective healthcare policies.
Incidence of venous thromboembolism in advanced lung cancer and efficacy and safety of direct oral anticoagulants: a multicenter, prospective, observational study (Rising-VTE/NEJ037 study)
Authors: Tsubata Yukari , Hotta Takamasa , Hamai Kosuke , Furuya Naoki , Yokoyama Toshihide , Saito Ryota , Nakamura Atsushi , Masuda Takeshi , Hamaguchi Megumi , Kuyama Shoichi , Honda Ryoichi , Senoo Tadashi , Nakanishi Masamoto , Yamasaki Masahiro , Ishikawa Nobuhisa , Fujitaka Kazunori , Kubota Tetsuya , Ohtsu Hiroshi , Kobayashi Kunihiko , Isobe Takeshi 
Published: July 2022

Background: Venous thromboembolism (VTE) is a well-known type of cancer-associated thrombosis and a common complication of malignancy. However, the incidence of VTE associated with lung cancer and the effectiveness of direct oral anticoagulants remain unclear. This study aimed to identify the incidence of VTE associated with lung cancer at the time of diagnosis or during treatment, the efficacy and safety of edoxaban, and associated risk factors. Methods: The Rising-VTE/NEJ037 study was a multicenter prospective observational study. Altogether, 1021 patients with lung cancer who were unsuitable for radical resection or radiation were enrolled and followed up for 2 years. Patients with VTE at the time of lung cancer diagnosis started treatment with edoxaban. The primary endpoint of this trial was the rate of newly diagnosed VTE after enrollment or recurrence rate 6 months after treatment initiation. Results: Data were available for 1008 patients. The median age was 70 years (range: 30–94 years), and 70.8% were men. Sixty-two patients had VTE at the time of lung cancer diagnosis, and 38 (9.9%) developed VTE at follow-up. No cases of VTE recurrence were recorded 6 months after treatment initiation with edoxaban. Major and clinically relevant non-major bleeding events occurred in 4.9% of patients and increased to 22.7% in the edoxaban treatment group. Conclusions: VTE occurrence should be monitored during lung cancer treatment. Although treatment with edoxaban was highly effective in preventing VTE recurrence, its administration should be cautiously considered because of the high bleeding rate. Trial registration: jRCTs061180025.
Risk assessment in systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study
Authors: Wang Qian , Qian Junyan , Li Mengtao , Zhang Xiao , Wei Wei , Zuo Xiaoxia , Zhu Ping , Ye Shuang , Zhang Wei , Zheng Yi , Qi Wufang , Li Yang , Zhang Zhuoli , Ding Feng , Gu Jieruo , Liu Yi , Huang Can , Zhao Jiuliang , Liu Yongtai , Tian Zhuang , Wang Yanhong , Zhang Miaojia , Zeng Xiaofeng 
Published: July 2022

Objective: This study evaluated the prognostic value of the multivariable risk assessment for systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH). Methods: A multicenter prospective cohort of SLE-associated PAH (CSTAR-PAH cohort) diagnosed based on right heart catheterization (RHC) was established. Baseline and follow-up records were collected. Three methods of risk assessment, including (1) the number of low-risk criteria, based on World Health Organization functional class (WHO FC), 6-min walking distance (6MWD), right atrial pressure (RAP), and cardiac index (CI); (2) the three-strata stratification based on the average risk score of four variables (WHO FC, 6MWD, RAP, and CI); and (3) the four-strata stratification based on COMPARE 2.0 model were applied. A risk-assessment method using three noninvasive low-risk criteria was applied at the first follow-up visit. Survival curves between patients with different risk groups were compared by Kaplan–Meier’s estimation and log-rank test. Results: Three-hundred and ten patients were enrolled from 14 PAH centers. All methods of stratification at baseline and first follow-up significantly discriminated long-term survival. Survival rates were also significantly different based on the noninvasive risk assessment in first follow-up visit. Survival deteriorated with the escalation of risk from baseline to first follow-up. Patients with baseline serositis had a higher rate of risk improvement in their follow-up. Conclusion: The risk assessment has a significant prognostic value at both the baseline and first follow-up assessment of SLE-associated PAH. A noninvasive risk assessment can also be useful when RHC is not available during follow-up. Baseline serositis may be a predictor of good treatment response in patients with SLE-associated PAH.
“Saving Our Boys!”: Do Chinese Boys Have a Masculinity Crisis?
Authors: Zhu (祝刚) Gang , Zhang (张爱东) Aidong , Cheng (程力) Li , Shi (史可媛) Keyuan , Wang (王语婷) Yuting 
Published: July 2022

Highlights The issue of the boy (masculinity) crisis was examined in both the global and Chinese contexts. To examine the authenticity of the masculinity crisis in China, we first historicized the debate on the boy crisis between Yunxiao Sun (孙云晓) and An'qi Xu (徐安琪) in China and its implications. Then, we examined the contributing factors to the masculinity crisis from the social-ecological perspective, which encompasses the familial (helicopter parenting style), educational (burdensome academic pressure), and societal (feminine and misleading social media) factors. We concluded that the Chinese masculinity crisis has evolved into a socio-cultural issue in recent years. We suggest the potentials of gender-relevant pedagogy and the collective capability among various stakeholders in addressing the boy crisis.
Clustering of Social Determinants of Health Among Patients
Authors: Schiltz Nicholas K. , Chagin Kevin , Sehgal Ashwini R. 
Published: July 2022

Introduction/Objectives: Many health systems screen patients for social determinants of health and refer patients with social needs to community organizations for assistance. Understanding how social determinants cluster together may help guide assistance programs. Methods: This study examined patients screened by The MetroHealth System in Cleveland, Ohio for 9 social determinants, including food insecurity, financial strain, transportation limitations, inability to pay for housing or utilities, intimate partner violence, social isolation, infrequent physical activity, daily stress, and lack of internet access. Clustering analyses were performed to determine which combination of social determinants occurred together more often than would be expected if each determinant were independent of each other. Results: Among 23 161 screened patients, there were 19 dyads, 13 triads, and one tetrad of social determinants that clustered together. The most prevalent triad of food insecurity, social isolation, and inability to pay for housing or utilities occurred among 1095 patients but would be expected to occur among 284 patients, for an observed/expected ratio of 3.85 (95% confidence interval 3.64-4.07). In multivariate analyses, younger, Black, and lower income patients were 2 to 3 times more likely to have this triad compared to older, White, and wealthier patients. Conclusions: Social determinants of health frequently cluster together, and such clustering is associated with patient demographic characteristics. Further work is needed to determine how social determinant clusters impact health and cost outcomes and to develop programs that can address multiple co-existing social needs.
Postoperative Opioid Use and Prescribing Patterns among Patients Undergoing Cervical Laminectomy with Instrumented Fusion versus Cervical Laminoplasty with Reconstruction
Authors: Shankar Dhruv S. , Kim Jinseong , Bienstock Dennis M. , Gao Michael , Lee Yunsoo , Zubizarreta Nicole J. , Poeran Jashvant , Lin James D. , Chaudhary Saad B. , Hecht Andrew C. 
Published: July 2022

Study Design Retrospective cohort study. Objective To compare patterns in opioid usage and prescriptions between patients who undergo cervical laminectomy with instrumented fusion (LF) vs cervical laminoplasty with reconstruction (LP) within single surgeon and national database cohorts. Methods We identified patients with cervical myelopathy undergoing primary LF or LP in both a single-surgeon series cohort (2004-2018) and a nationally representative cohort drawn from the IBM® Marketscan® database (2014-2016). We recorded opioid usage within 6 months of surgery and identified differences in unadjusted opioid use rates between LF and LP patients. Multivariable logistic regression was used to evaluate the association between procedure type and postoperative opioid use. Results Without adjusting for covariates, LF patients had a higher rate of 6-month opioid use in the single-surgeon cohort (15.7% vs 5.1%, P = .02). After adjusting for covariates, LF patients had higher odds of 6-month postoperative opioid use (OR 2.8 [95% CI 1.0-7.7], P = .04). In the national cohort, without adjusting for covariates, there was no significant difference in 6-month opioid use between LF and LP patients. Even after adjusting for covariates, we found no significant difference in odds. Conclusions Findings from a single-surgeon cohort reveal that LF is associated with a higher rate of 6-month opioid use than LP. This is at odds with findings from a national database cohort, which suggested that LP and LF patients have similar rates of opioid usage at 6-months postoperatively. To prevent overuse of narcotics, surgeons must consider the distinct pain requirements associated with different procedures even in treatment of the same condition.
Computed tomographic perfusion abnormalities in acute migraine with aura: Characteristics and comparison with transient ischemic attack
Authors: Strambo Davide , Nannoni Stefania , Rebordão Leonor , Dunet Vincent , Michel Patrik 
Published: July 2022

Introduction: Migraine with aura (MA) accounts for up to 10% of “stroke mimics” and can present cerebral perfusion abnormalities. We aimed to compare perfusion-CT (PCT) findings in acute-onset MA mimicking an ischemic stroke with those observed in transient ischemic attack (TIA). Methods: We retrospectively studied patients admitted to our hospital between 2002 and 2014 with suspicion of acute ischemic stroke, having PCT and receiving a final diagnosis of MA. We visually assessed PCT for the presence and extent of focal hypoperfusion (FHP). MA patients with FHP were compared with consecutive TIA patients showing FHP. We performed both qualitative and quantitative analysis of PCT. Results: Of 47 patients with MA (median age = 33 years, 55% females), 16 (34%) displayed FHP. Compared to MA patients without FHP, MA patients with FHP had similar headaches and aura features, but a less frequent history of MA ( p = 0.010). Compared to 74 TIA patients with FHP (median age = 69 years, 43% females), MA patients with FHP showed hypoperfusion that more frequently involved adjacent vascular territories or a whole hemisphere ( p < 0.001). In addition, hypoperfusion in MA patients had a less pronounced increase in rMTT (1.2 vs 1.8, p < 0.001) and rTTP (1.1 vs 1.2, p < 0.001), and a lesser decrease in rCBF (0.8 vs 0.6, p < 0.001) compared to hypoperfusion in TIA. rMTT displayed the best discriminative ability to differentiate MA from TIA. Conclusion: Focal perfusion abnormalities in acute MA often involve adjacent vascular territories and hypoperfusion is less pronounced than in TIA. MA can be best differentiated from TIA by a smaller rMTT increase.