bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining programmed cell death ligand 1 expression in circulating tumor cells of patients with clear cell renal cell carcinoma and its correlation with response to programmed cell death protein 1 inhibitors
Authors: Chen Bo‐Han , Kao Chien‐Chang , Xu Ting , Yang Yung‐Ning , Cha Tai‐Lung , Tsai Yi‐Ta , Liu Shu‐Yu , Wu Sheng‐Tang , Meng En , Tsao Chih‐Wei , Chen Chin‐Li , Sun Guang‐Huan , Yu Dah‐Shyong , Chang Sun‐Yran , Yang Ming‐Hsin 
Published: February 2022

ObjectiveThere is a great interest in determining whether the expression of the programmed cell death ligand 1 is correlated with the efficacy of immune checkpoint inhibitors in patients with clear cell renal cell carcinoma; however, primary tumor biopsies can only provide limited information. Therefore, we explored the expression of programmed cell death ligand 1 on circulating tumor cells, which is a potential predictor of therapeutic response.MethodsCirculating tumor cells were isolated from 20 clear cell renal cell carcinoma patients based on cell surface markers targeting clear cell renal cell carcinoma using IsoFlux device, followed by identification according to cell morphology and immunofluorescence studies. Programmed cell death ligand 1 expression status and clinical correlations were also analyzed.ResultsBefore treatment with programmed cell death protein 1 inhibitors, circulating tumor cells were detected in all patients, ranging from 1 to 22 (median 7), with 75% (15/20) of the patients having programmed cell death ligand 1 + circulating tumor cells. Circulating tumor cell programmed cell death ligand 1 expression did not correlate with the immunohistochemical staining of programmed cell death ligand 1 in primary tumors. During treatment with programmed cell death protein 1 inhibitors, the disease control rate was much higher in the patients harboring programmed cell death ligand 1 + circulating tumor cells (73%, 11/15) than others (20%, 1/5). We also found that changes in total circulating tumor cell numbers and programmed cell death ligand 1 + circulating tumor cell counts correlated well with the disease outcome.ConclusionWe showed that the presence of programmed cell death ligand 1 + circulating tumor cells before programmed cell death protein 1 inhibition treatment could be a prognosis predictive factor and that the dynamic changes in circulating tumor cell numbers may be used to monitor the therapeutic response. Our study confirms the possibility of programmed cell death ligand 1 + circulating tumor cell detection in clear cell renal cell carcinoma patients’ blood samples, which can potentially be used as an individualized immunotherapy molecular biomarker for real‐time exploration.
Evaluation of mandibular trabecular bone by fractal analysis on panoramic radiograph in paediatric patients with sleep bruxism
Authors: Kolcakoglu Kevser , Amuk Mehmet , Sirin Sarıbal Gamze 
Published: February 2022

AbstractObjectiveTo evaluate the trabecular bone density in the mandible of paediatric patients diagnosed with sleep bruxism (SB) using the fractal analysis method on panoramic radiographs.MethodsA total of 37 patients whose anamnesis and clinical signs were compatible with SB were diagnosed with SB using BiteStrip®. Three areas were identified on the panoramic radiographs of the patients: the geometric center of the condyle, the angulus region under the mandibular canal, and the distal region of the mental foramen. Regions of interest (ROIs) of 60 × 60 pixels were selected in these three locations, and fractal dimensions (FDs) were calculated. Results were compared with the control group.ResultsThere was no statistically significant difference between the right and left FD values, and male and female FD values in all regions and both groups (p > .05). In the angulus (p = .03) and condyle (p = .03) regions, the SB group had a significantly higher FD value than the control group. There was no statistically significant difference between the SB and control groups in the corpus region (p = .98). A moderate negative correlation arose between age and condyle FD values among controls (r = −0.38, p = .02).ConclusionFractal dimension values evaluating trabeculation of the mandibular bone are affected by SB in the angulus and condyle regions.
Machine learning enabled closed‐form models to predict strength of alkali‐activated systems
Authors: Han Taihao , Gomaa Eslam , Gheni Ahmed , Huang Jie , ElGawady Mohamed , Kumar Aditya 
Published: February 2022

AbstractAlkali‐activated mortar (AAM) is an emerging eco‐friendly construction material, which can complement ordinary Portland cement (OPC) mortars. Prediction of properties of AAMs—albeit much needed to complement experiments—is difficult, owing to substantive batch‐to‐batch variations in physicochemical properties of their precursors (i.e., aluminosilicate and activator solution). In this study, a machine learning (ML) model is employed; and it is shown that the model—once trained and optimized—can reliably predict compressive strength of AAMs solely from their initial physicochemical attributes. Prediction performance of the model improves when multiple compositional descriptors of the aluminosilicate are combined into a singular, composite chemostructural descriptor (i.e., network ratio and number of constraints); thus, reducing the degrees of freedom. Through interpretation of the ML model's outcomes—specifically the variable importance for the AAMs’ compressive strength—a simple, easy‐to‐use, closed‐form analytical model is developed. Results demonstrate that the analytical model yields predictions of compressive strength of AAMs without scarifying much accuracy compared to the ML model. Overall, this study's outcomes demonstrate a roadmap—incorporates composite chemostructural descriptors in ML models—that can be employed to design AAMs to achieve targeted compressive strength.
Association between sleep and quality of life in heart failure patient–caregiver dyads and mediation of fatigue: An actor–partner interdependence mediation model
Authors: Zhang Jie , Chai Xiaohui , Ye Yi , Zhao Qiuge , Fan Xiuzhen 
Published: February 2022

AbstractAimsQuality of life is essential to heart failure patients and their family caregivers. This study aimed to examine the mediating role of fatigue in the association between sleep and quality of life in heart failure patient–caregiver dyads.DesignA cross‐sectional descriptive study was conducted from November 2017 to August 2018.MethodsA total of 269 heart failure patient–caregiver dyads at two hospitals in China were included. The Chinese version of the Pittsburgh Sleep Quality Index, the Chalder Fatigue Scale and the 12‐item Short‐Form Health Survey were used to collect data on heart failure patients and their family caregivers. The structural equation model was employed in the dyadic analysis based on the actor–partner interdependence mediation model.ResultsRegarding the actor effects, poor sleep was negatively associated with physical and mental quality of life in heart failure patients and their family caregivers, respectively, and the relationship was mediated by their fatigue. Regarding the partner effects, caregivers' fatigue was positively associated with patients' physical quality of life and mediated the association between caregivers' sleep and patients' physical quality of life.ConclusionsHeart failure patients and their family caregivers experience reduced quality of life when they have poor sleep and fatigue, and caregivers' fatigue is related to patients' improved physical quality of life. Hence, dyadic interventions targeting to improving sleep and fatigue may be beneficial to their quality of life.ImpactThis study highlights the importance of routinely measuring and managing sleep and fatigue for heart failure patients and their family caregivers. Effective dyadic‐based interventions that maintain equal attention to family caregivers should be considered by healthcare providers to maximize the improvement of patients' quality of life.
Mcl‐1 inhibition overcomes BET inhibitor resistance induced by low FBW7 expression in breast cancer
Authors: Wang Xu , Wei Xiaolin , Cao Yu , Xing Peng 
Published: February 2022

AbstractWhile the promise of bromodomains and extraterminal (BET) protein inhibitors (BETis) is emerging in breast cancer (BC) therapy, resistance in these cells to BETis conspicuously curbs their therapeutic potential. FBW7 is an important tumour suppressor. However, the role of FBW7 in BC is not clear. In the current study, our data indicated that the low expression of FBW7 contributes to the drug resistance of BC cells upon JQ1 treatment. shRNA‐mediated FBW7 silencing in FBW7 WT BC cells suppressed JQ1‐induced apoptosis. Mechanistically, it was revealed that this diminished FBW7 level leads to Mcl‐1 stabilization, while Mcl‐1 upregulation abrogates the killing effect of JQ1. Mcl‐1 knockdown or inhibition resensitized the BC cells to JQ1‐induced apoptosis. Moreover, FBW7 knockdown in MCF7 xenografted tumours demonstrated resistance to JQ1 treatment. The combination of JQ1 with a Mcl‐1 inhibitor (S63845) resensitized the FBW7 knockdown tumours to JQ1 treatment in vivo. Our study paves the way for a novel therapeutic potential of BETis with Mcl‐1 inhibitors for BC patients with a low FBW7 expression.
Invasive dental treatment and acute vascular events: A systematic review and meta‐analysis
Authors: Luthra Shailly , Orlandi Marco , Leira Yago , Bokre Desta , Marletta Debora , Rotundo Roberto , Harden Simon , D'Aiuto Francesco 
Published: February 2022

AbstractBackgroundAcute infection/inflammation increases the risk of acute vascular events (AVEs). Invasive dental treatments (IDTs) trigger short‐term acute inflammation.PurposeThe aim of this work is to critically appraise the evidence linking IDTs and AVEs.Data SourcesSix bibliographical databases were searched up to 31 August 2021. A systematic review following PRISMA guidelines was performed.Study SelectionIntervention and observational studies reporting any AVEs following IDT were included.Data ExtractionTwo reviewers independently extracted data and rated the quality of studies. Data were pooled using fixed‐effect, inverse variance weights analysis.Risk of BiasRisk of bias was assessed by the Newcastle–Ottawa Quality Assessment Scale for observational studies and the Cochrane Handbook–Rob 2.0 for randomized controlled trials.Data SynthesisIn 3 out of 16 clinical studies, a total of 533,175 participants, 124,344 myocardial infarctions, and 327,804 ischaemic strokes were reported. Meta‐analysis confirmed that IDT did not increase incidence ratios (IR) for combined vascular events either at 1‐4 weeks (IR of 1.02, 95% CIs: 0.92 to 1.13) and at 5‐8 weeks (IR of 1.04, 95% CIs: 0.97 to1.10) after treatment.LimitationsA high level of heterogeneity (study designs and time point assessments) was found.ConclusionPatients who received IDT exhibited no substantial increase in vascular risk over 8 weeks post treatment.
A person‐centred, theory‐based, behavioural intervention programme for improved oral hygiene in adolescents: A randomized clinical field study
Authors: Dimenäs Sandra L. , Jönsson Birgitta , Andersson Jessica S. , Lundgren Jesper , Petzold Max , Abrahamsson Ingemar , Abrahamsson Kajsa H. 
Published: February 2022

AbstractAimTo test the effectiveness of a person‐centred and theory‐based educational intervention to increase adolescents′ adherence to adequate oral hygiene behaviour, that is, self‐performed periodontal infection control.Materials and MethodsData were derived from a prospective, multi‐centred, two‐arm, quasi‐randomized field study in which treatment was performed by dental hygienists (DHs) within the Public Dental Service, Västra Götaland, Sweden. Adolescents with poor oral hygiene conditions were invited to participate. The test intervention was based on cognitive behavioural theory and principles, and the DHs used a collaborative communicative approach, inspired by motivational interviewing. The control intervention consisted of conventional information/instruction. Clinical assessments and oral hygiene behaviours were evaluated at 6 months.ResultsThree‐hundred and twelve adolescents were enrolled, of whom 274 followed the treatment to 6‐month follow‐up. There were significant improvements in gingival bleeding and plaque scores for both treatment groups at 6 months, with significantly greater improvements in the test group. Adolescents in the test group brushed their teeth and used interdental cleaning aids more frequently compared to participants in the control group at 6 months.ConclusionA person‐centred and theory‐based oral health education programme is more effective than conventional oral health education in improving adolescents' oral hygiene behaviour and periodontal infection control. ClinicalTrials.gov (NCT02906098).
Development and evaluation of continuous inshelled walnut processing system
Authors: Hussain Syed Zameer , Naseer Bazila , Qadri Tahiya , Reshi Monica , Amin Tawheed , Kanojia Varsha 
Published: February 2022

AbstractWalnut is one of the high yielding fruit crops grown in union territory of Jammu and Kashmir (J&K) in India. However, processing of walnuts in J&K is being carried out manually, which is very tedious, troublesome, and time and labor consuming. Thus, the present work was undertaken with an aim to develop a single mechanized continuous system for post‐harvest handling and processing of walnuts. The innovation composed of dehulling, bleaching, washing, drying, and grading units, besides conveyors to carry walnuts from one unit to another. The dehulling efficiency (95.70%), bleaching efficiency (96.28%), washing efficiency (99.10%), and grading efficiency (97.43%) recorded for the developed system are much higher than the manual processing. Furthermore, number of partially dehulled, un‐dehulled, partially bleached, unbleached, and damaged walnut percentages were recorded significantly (p < 0.05) lower whereas fully dehulled and fully bleached walnut percentages were recorded significantly (p < 0.05) higher in case of developed system as compared with manual processing. Overall capacity and efficiency of the developed system were recorded as 800 kg/day and 97.02%, respectively. The labor requirement for processing 1 ton of walnuts using developed system was determined to be 10 man h. The economic analysis indicated that adoption of developed system for walnut processing can be highly beneficial and economic. Thus, developed system can be a feasible alternative to minimize the post‐harvest losses, to maintain the quality, and to overcome the drudgery, boredom, and constraints associated with manual post‐harvest handling and processing of walnuts.Practical ApplicationsJammu and Kashmir (J&K) has the largest share in India's total walnut production. However, from the last few years, there has been a setback to the export trade potential of walnuts in India, mainly due to import of walnuts from China and California. The walnuts from California and China have better consumer acceptability than walnuts of J&K, which has badly affected the walnut trade in India. In J&K, post‐harvest handling of walnuts is being done manually without any scientific and mechanical arbitration, which leads to quality deterioration of walnuts. Therefore, in order to compete at international level, there is an immediate need to shift the post‐harvest handling of walnuts from manual to mechanized. Thus, the adoption of developed continuous inshelled walnut processing system can play a vital role in sustaining the rural economy of J&K through production and sale of good quality walnuts. Furthermore, the developed system can serve as a benchmark for establishment of modern walnut processing units, which can lead to employment generation and boost the walnut trade in J&K.
Science catching up: Experiential family therapy and neuroscience
Authors: Bailey Molly E. 
Published: February 2022

AbstractExperiential family therapy, pioneered by Virginia Satir and Carl Whitaker, centered the experience of the “here and now,” human authenticity and congruent communication in the work of psychotherapy. Their approach—often considered atypical and atheoretical—was popular for a while, then relegated as behavioral and cognitive theories developed. However, with the proliferation of modern neuroscience, particularly the field of Interpersonal Neurobiology, therapists can see neuroscience research providing hard data and respective frameworks delineating the underlying architecture for understanding the connections between the mind, emotions, behavior, and relationships. This article highlights the neurobiological mechanisms that explain why classic experiential family therapy was so powerful. The main tenets of both Carl Whitaker's symbolic experiential family therapy as well as Virginia Satir's model for peoplemaking are illuminated through the postulates and scientific findings of interpersonal neurobiology.
The impact of the COVID‐19 pandemic on subsistence consumers' well‐being and coping strategies: Insights from India and Bangladesh
Authors: Nath Shobod Deba , Jamshed Kazi Md. , Shaikh Javed M. 
Published: February 2022

AbstractThe impact of the COVID‐19 pandemic on the overall well‐being of consumers is disastrous. However, there is limited understanding of how the COVID‐19 situation affects consumer well‐being and how subsistence consumers mitigate well‐being concerns and unique stresses. Following an exploratory, qualitative approach, 39 in‐depth semi‐structured interviews with subsistence consumers were conducted in India and Bangladesh. Findings from the thematic analysis reveal that subsistence consumers experienced unique stresses and hardships during COVID‐19, which are unforeseen transitory financial stress, psychosocial stress, and marketplace and consumption‐related stresses. Drawing on the appraisal theory of stress, our analysis of the data identifies the co‐existence of two emotion‐focused coping strategies—religiosity and social support—that interplay to overcome their well‐being concerns in the emerging countries of India and Bangladesh. Therefore, it may be of particular interest to managers and policymakers who seek to address the severe consequences of the COVID‐19 pandemic on socio‐economically subsistence consumers.
Associations between presence ofBartonellaspecies deoxyribonucleic acid and complete blood cell count and serum biochemical changes in client‐owned cats
Authors: Williams Maggie , Rao Sangeeta , Braff Jennifer , Buch Jesse S. , Chandrashekar Ramaswamy , Lappin Michael R. 
Published: February 2022

AbstractBackgroundInfection withBartonellaspecies is common in cats but reported effects of bacteremia on laboratory variables differ.ObjectivesEvaluate for associations betweenBartonellabacteremia and CBC and serum biochemical changes in sick and healthy cats throughout the United States.AnimalsA total of 3964 client‐owned cats.MethodsRetrospective cohort study using submissions to a commercial laboratory between 2011 and 2017. Serum biochemistry and CBC abnormalities (categorized as above or below reference intervals), age, and location (high‐ or low‐risk state forCtenocephalides felis) in presumed healthy and sick cats were evaluated for associations with presence ofBartonellaspp. DNA, detected by PCR. Univariate and multivariable logistic regression analyses were performed.ResultsBartonellaspp. DNA was amplified from 127 (3.2%) of 3964 cats; 126 (99.2%) of 127 were from high flea risk states and 121 (95.3%) of 127 were presumed sick. Fever of unknown origin was the most common PCR panel requested. In the multivariable analysis, neutrophilia, decreased ALP activity, clinical status (presumed sick), and young age (≤2 years) each were positively associated whereas neutropenia and hyperproteinemia both were negatively associated withBartonellaspp. bacteremia. Presence ofBartonellaspp. DNA had no association with test results for other infectious disease agents.Conclusions and Clinical ImportanceIn both healthy and sick cats, activeBartonellainfections had minimal association with clinically relevant laboratory abnormalities. However, based on these results, in areas considered high risk forC. felis, active infection withBartonellaspp. is a reasonable differential diagnosis for cats presented with unexplained fever and neutrophilia, particularly if the cat is young.
Complex burial histories of Apollo 12 basaltic soil grains derived from cosmogenic noble gases: Implications for local regolith evolution and future in situ investigations
Authors: Nottingham Mark C. , Stuart Finlay M. , Chen Biying , Zurakowska Marta , Gilmour Jamie D. , Alexander Louise , Crawford Ian A. , Joy Katherine H. 
Published: February 2022

AbstractWe report the concentrations and isotope ratios of light noble gases (He, Ne, Ar) in 10 small basalt fragments derived from lunar regolith soils at the Apollo 12 landing site. We use cosmic ray exposure (CRE) and shielding condition histories to consider their geological context. We have devised a method of using cosmogenic Ne isotopes to partition the CRE history of each sample into two stages: a duration of “deep” burial (shielding of 5–500 g cm−2) and a duration of near‐surface exposure (shielding of 0 g cm−2). Three samples show evidence of measurable exposure at the lunar surface (durations of between 6 ± 2 and 7 ± 2 Myr). The remaining seven samples show evidence of a surface residence duration of less than a few hundred thousand years prior to collection. One sample records a single‐stage CRE age range of between 516 ± 36 and 1139 ± 121 Myr, within 0–5 g cm−2 of the lunar surface. This is consistent with derivation from ballistic sedimentation (i.e., local regolith reworking) during the Copernicus crater formation impact at ~800 Myr. The remaining samples show CRE age clusters around 124 ± 11 Myr and 188 ± 15 Myr. We infer that local impacts, including Surveyor crater (180–240 Ma) and Head crater (144 Ma), may have brought these samples to depths where the cosmic ray flux was intense enough to produce measurable cosmogenic Ne isotopes. More recent small impacts that formed unnamed craters may have exhumed these samples from their deep shielding conditions to the surface (i.e., ~0–5 g cm−2) prior to collection from the lunar surface during the Apollo 12 mission.
A thematic cluster analysis of parents' online discussions about fussy eating
Authors: Markides Brittany R. , Laws Rachel , Hesketh Kylie , Maddison Ralph , Denney‐Wilson Elizabeth , Campbell Karen J. 
Published: February 2022

AbstractFood fussiness is associated with non‐responsive parent feeding practices, such as persuasive and instrumental feeding. Although most children described as ‘fussy eaters’ are likely exhibiting developmentally typical behaviours, up to half of the parents of children 2–5 years old express concerns. Concern for fussy eating may mediate the use of non‐responsive feeding practices and so must be addressed in parent feeding interventions. Therefore, it is critical to better understand parents' concerns and how they may relate to feeding practices. This study aimed to explore how parents' feeding practices and the social cognitive factors that may drive them clustered based on parents' concern for fussy eating. Data were collected from parent discussions of fussy eating on a Reddit forum (80,366 posts). Latent Dirichlet allocation was used to identify discussions of fussy eating. Relevant posts (1542) made by users who identified as a parent of a fussy eater (n = 630) underwent qualitative coding and thematic analysis. Five clusters of parents were identified, ranging in size from 53 to 189 users. These were primarily characterised by parents' degree of concern and feeding practices: (1) High concern, nonresponsive; (2) Concerned, nonresponsive; (3) Low concern, responsive; (4) Low concern, mixed strategies; (5) Low concern, indulgent. Parents who used responsive practices tended to be less concerned for fussy eating, have greater trust in their child's ability to self‐regulate hunger, have longer‐term feeding goals, and exhibit greater ability for personal self‐regulation. Future research should further examine how these constructs may be leveraged in parent feeding interventions.