bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-1 in Coronary Artery Disease
Authors: Oikonomou Evangelos , Tsaplaris Paraskevas , Anastasiou Artemis , Xenou Maria , Lampsas Stamatios , Siasos Gerasimos , Pantelidis Panteleimon , Theofilis Panagiotis , Tsatsaragkou Aikaterini , Katsarou Ourania , Sagris Marios , Vavuranakis Michael-Andrew , Vavuranakis Manolis , Tousoulis Dimitris 
Published: October 2022

Abstract:
Cardiovascular disease is the leading cause of mortality worldwide. Inflammation has long been established as a key component in the pathophysiology of coronary artery disease. The interleukin-1 family consists of 11 members that regulate the inflammatory response through both pro- and anti-inflammatory properties with the Nod-like receptor (NLR) family pyrin domain con-taining 3 inflammasome having a pivotal role in the process of converting interleukin-1 beta and in-terleukin-18, two key inflammatory mediators, into their mature forms. Interleukin-1 affects various cell types that participate in the pathogenesis of atherosclerosis as it enhances the expression of leu-kocyte adhesion molecules on the surface of endothelial cells and augments the permeability of the endothelial cell barrier, attracting monocytes and macrophages into the vessel wall and aids the mi-gration of smooth muscle cells toward atheroma. It also enhances the aggregation of low-density lipoprotein particles in endothelium and smooth muscle cells and exhibits procoagulant activity by inducing synthesis, cell-surface expression and release of tissue factor in endothelial cells, promot-ing platelet adhesion. The value of interleukin-1 as a diagnostic biomarker is currently limited, but interleukin-1 beta, interleukin-18 and interleukin-37 have shown promising data regarding their prognostic value in coronary artery disease. Importantly, target anti-inflammatory treatments have shown promising results regarding atherosclerosis progression and cardiovascular events. In this re-view article, we focus on the immense role of interleukin-1 in atherosclerosis progression, inflam-mation cascade and in the clinical application of target anti-inflammatory treatments.
It is all About the Chase: Neurosteroidogenesis in Male Rats is Driven by
Control of Mating Pace
Authors: Kohtz Amy S. , Frye Cheryl A. 
Published: October 2022

Background:
Masculine sexual behaviors are dependent on androstane-derived steroids;
however, the modulatory effects of mating, and of mating control, on androstane neurosteroidogenesis
remain largely unknown.

Objective:
Herein, we investigated the effects of mating control, prior sexual experience, and age on
brain region specific neurosteroidogenic responses in male rats.

Methods:
Effects of acute sexual experience were tested in naïve male rats that either remained sexually-
naïve, were exposed to a standard mating chamber, or were either given control of the mating
pace in a standard mating chamber (male control) or mated wherein the female stimulus rat controlled
the mating pace in a paced-mating chamber (female control). Aged (10-12 months) sexually responsive
male rats were similarly euthanized from the homecage or engaged in male controlled or female
controlled mating. All rats were euthanized immediately following exposure conditions for radioimmunoassay
of steroids in midbrain, hypothalamus, hippocampus and cortex.

Results:
Consummatory sexual behavior in male vs. female-controlled mating paradigms was altered
by age and prior sexual experience. Male-controlled mating increased androstane neurosteroid metabolism,
such that complementary increases in the testosterone (T) metabolite 5α-androstane-3α-17β-
diol (3α-diol) in the midbrain and hypothalamus of male rats corresponded to decreases in the prohormone,
T. 3α-diol were increased in the hippocampus in response to the context alone, and to a lesser
degree in response to mating. Mating diminished neurosteroidogenesis in the cortex. Neurosteroidogenesis
was overall reduced in aged male rats compared to naïve controls, however, these effects were
more prominent in sexually non-responsive aged male rats.

Conclusions:
Extending previous findings, these results indicate differential production of androstane
neurosteroids in a mating exposure, age and brain region dependent manner.
Electroencephalography Findings in Traumatic Brain Injury
Authors: Kadri Alfansuri , Apriani Novi 
Published: October 2022

Traumatic Brain Injury (TBI) or also known as a head injury is one of the leading causes of death among young people and is also one of the health problems defined as impact, penetration, and rapid movement of the brain within the skull that can result in changes in mental status and is often referred to as the silent epidemic.
Head injuries can also result in electrophysiological abnormalities seen on electroencephalography (EEG) recordings. Electroencephalography was the first clinical neurodiagnostic assessment to reveal abnormal brain function after a head injury. For detecting brain injury, EEG may be more sensitive than clinical neurologic examination.
In general conditions, electroencephalography is performed on patients with moderate to severe head injuries to provide information about the severity of the head injury, and establish a diagnosis of non-convulsive status epilepticus. This diagnosis often follows head injuries because patients with loss of consciousness are difficult to identify without an EEG examination. This also helps determine a prognosis for recovery and the likelihood of post-traumatic seizures.
Electroencephalography features in head injuries depend on the severity of the injury and the location of the head itself. Electroencephalography after head injury shows slowing of the posterior dominant rhythm and increasing diffuse theta slowing, which returns to normal within hours or may subside more slowly over several weeks. Electroencephalography changes are not the same in each individual, due to differences in the severity of head injuries. It is important to know that there is no clear or specific EEG for mild traumatic brain injury.
Integration of Artificial Intelligence Into Sociotechnical Work Systems—Effects of Artificial Intelligence Solutions in Medical Imaging on Clinical Efficiency: Protocol for a Systematic Literature Review
Authors: Wenderott Katharina , Gambashidze Nikoloz , Weigl Matthias 
Published: October 2022

Background
When introducing artificial intelligence (AI) into clinical care, one of the main objectives is to improve workflow efficiency because AI-based solutions are expected to take over or support routine tasks.

Objective
This study sought to synthesize the current knowledge base on how the use of AI technologies for medical imaging affects efficiency and what facilitators or barriers moderating the impact of AI implementation have been reported.

Methods
In this systematic literature review, comprehensive literature searches will be performed in relevant electronic databases, including PubMed/MEDLINE, Embase, PsycINFO, Web of Science, IEEE Xplore, and CENTRAL. Studies in English and German published from 2000 onwards will be included. The following inclusion criteria will be applied: empirical studies targeting the workflow integration or adoption of AI-based software in medical imaging used for diagnostic purposes in a health care setting. The efficiency outcomes of interest include workflow adaptation, time to complete tasks, and workload. Two reviewers will independently screen all retrieved records, full-text articles, and extract data. The study’s methodological quality will be appraised using suitable tools. The findings will be described qualitatively, and a meta-analysis will be performed, if possible. Furthermore, a narrative synthesis approach that focuses on work system factors affecting the integration of AI technologies reported in eligible studies will be adopted.

Results
This review is anticipated to begin in September 2022 and will be completed in April 2023.

Conclusions
This systematic review and synthesis aims to summarize the existing knowledge on efficiency improvements in medical imaging through the integration of AI into clinical workflows. Moreover, it will extract the facilitators and barriers of the AI implementation process in clinical care settings. Therefore, our findings have implications for future clinical implementation processes of AI-based solutions, with a particular focus on diagnostic procedures. This review is additionally expected to identify research gaps regarding the focus on seamless workflow integration of novel technologies in clinical settings.

Trial Registration
PROSPERO CRD42022303439; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=303439

International Registered Report Identifier (IRRID)
PRR1-10.2196/40485
Diffusion-tensor magnetic resonance imaging of the growth plates: substantiation of the method and evaluation of its reproducibility
Authors: Brovin D. A. , Trofimova T. N. , Kenis V. M. , Braylov S. A. 
Published: October 2022

INTRODUCTION: In recent years there is an increasing interest in assessing the state of the physis among pediatric orthopedic traumatologists, due to the availability of surgical correction of conditions associated with impaired growth plate function. Application of these methods requires dynamic assessment of the state of the physis. The existing methods for assessing the functional state of the physis are few and imperfect. Magnetic resonance imaging (MRI), in particular diffusion tensor imaging (DTI), is promising for assessing the growth plates.OBJECTIVE: To assess the possibility of applying DTI technique to assess the state of the physis (growth plate).MATERIALS AND METHODS: The study was approved by the local ethical committee of the Institute of the Human Brain named after N.P. Bekhtereva of Russian Academy of Sciences, protocol No. 32, dated 21.12.2020. Informed consent was obtained from each legal representative. At the Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery of the Ministry of Health of the Russian Federation a standard magnetic resonance examination of the knee joints was performed, additionally diffusion tensor tomography was performed in 75 patients aged 4.1 to 14.3 years (41 males, 34 females), both deemed healthy and with a known physeal pathology. The studies were performed using a Philips Ingenia ElitionX machine with a magnetic field strength of 3 Tesla, DTI was performed in the coronal plane, TE=71.2 ms, TR=4000 ms, b-factor value 600 s/mm2, 15 diffusion directions were used, slice thickness was 3 mm without gaps, the matrix size was 1.25×1.25 mm. The resulting images were processed using the DSI Studio software, including tract construction, estimation of the total volume and average length of the tracts. The reproducibility of the technique was assessed.RESULTS: Higher volumes and mean tract lengths were found in healthy males at puberty compared to other groups. When assessing reproducibility, the standard deviations were about 10% of the final value.DISCUSSION: Images of growth plate tracts were obtained. In individuals of pubertal age that were deemed healthy, the tract volume values and the average length of the tracts were higher than in individuals of prepubertal age and those with pathological conditions affecting the state of the growth plates. The average tract length turned out to be more reproducible than the total tract volume parameter.CONCLUSION: With the help of DTI, it is possible to evaluate the arrangement of the structures in the growth plates.
How has the SARS-CoV-2 pandemic changed the epidemiology and management of acute bronchiolitis?
Authors: Brisca Giacomo , Mariani Marcello , Buratti Silvia , Ferretti Marta , Pirlo Daniela , Buffoni Isabella , Mallamaci Marisa , Salvati Pietro , Tagliarini Giulia , Piccotti Emanuela , Sacco Oliviero , Castagnola Elio , Moscatelli Andrea 
Published: October 2022

Objective: SARS-COV-2 pandemic had a profound impact on acute
bronchiolitis epidemiology, especially in RSV diffusion and the burden
of disease with implications on the management of prophylaxis and health
resources. We aimed to compare clinical and epidemiological
characteristics of bronchiolitis before and during the SARS-CoV-2
pandemic. Methods: We conducted an observational study
involving children aged 0-2 years with bronchiolitis admitted to a
tertiary children’s hospital during the last 5 years. Demographic,
clinical, microbiological, and outcome data were collected. Comparison
between pre- and post-pandemic period, RSV positive versus non-RSV
patients, and SARS-CoV-2 positive vs negative patients were carried
out. Results: A total of 647 patients admitted for
bronchiolitis were included (264 female,40.8%, median age 78 days).
Molecular diagnostic tests were performed in 617 patients (95.4%) with
RSV detected in 62.5% of patients. SARS-CoV-2 was found in 3.9% of
hospitalized bronchiolitis (3.9%). We observed a progressive increase
in bronchiolitis admissions and a statistically significant increase
over the years in the need for respiratory support. Conversely, this was
not true for mechanical ventilation, duration of respiratory support,
ICU admission, and length of stay. During the pandemic period children
with prematurity increased, although only 1 child had an indication for
prophylaxis. Discussion: We confirm the stronger impact of
bronchiolitis in the 2021-22 season, which is likely explained by the
higher prevalence of RSV and the immunity debt theory. However, our
findings were conflicting in terms of worsening clinical severity. The
increase of children with prematurity and the inter-seasonal spread of
RSV highlight the importance of epidemiological surveillance systems
that monitor RSV circulation.
Impact Risk Management in Impact Investing: How Impact Investing Organizations Adopt Control Mechanisms to Manage Their Impact Risk
Authors: Islam Syrus M. 
Published: October 2022

ABSTRACT
In impact investing, impact risk encompasses the probability that investment projects may fail to achieve the expected positive impact (i.e., positive impact risk) and/or may have a negative impact (i.e., negative impact risk). Using an inductive research approach, this study examines how impact investing organizations adopt control mechanisms to manage impact risk. It finds that impact investors adopt a wide range of input, behavior, and output control mechanisms to manage impact risk that may arise from investee-level, investor-level, and system-level operations. Also, to manage impact risk, investors establish control mechanisms to influence relevant actors not only within a firm’s boundary but also outside its boundary. Given the inherent complexity and ambiguity in managing impact risk in impact investing, control mechanisms appear to rely heavily on judgment and experience and adhere more to the “satisficing” principle. Furthermore, investors tend to focus more on managing positive impact risk than negative impact risk.
Fifteen risk factors associated with sudden death in Thoroughbred racehorses in North America (2009–2021)
Authors: Bennet Euan D. , Parkin Tim D. H. 
Published: October 2022

Abstract

OBJECTIVE
To identify risk factors associated with race-related sudden death in Thoroughbred racehorses in the US and Canada.

ANIMALS
4,198,073 race starts made by 284,387 Thoroughbred horses at 144 racetracks in the US and Canada between 2009 and 2021.

PROCEDURES
Study data were extracted from the Equine Injury Database, which contains detailed records of 92.2% of all official race starts made in the US and Canada during the study period. Forty-nine potential risk factors were analyzed using univariable and multivariable logistic regression. Cases were defined as race starts that resulted in fatality within 3 days of racing, in which at least 1 of 5 codes relating to sudden death was recorded. Fatalities due to catastrophic musculoskeletal injury were omitted from the study cohort.

RESULTS
536 race starts resulted in sudden death, an incidence rate of 0.13/1,000 starts. Fifteen risk factors were significantly associated with sudden death, including horse age and sex, season and purse of race, race distance, and horses’ recent history of injury and lay-up. Horses racing while on furosemide medication were at 62% increased odds of sudden death.

CLINICAL RELEVANCE
Associations found between previous injury and sudden death suggests preexisting pathology could contribute in some cases. The association between furosemide and sudden death prompts further study to understand which biological processes could contribute to this result.
The fish community of the ancient Prespa Lake (Southeast Europe): Non-indigenous species take over
Authors: Pietrock Michael , Ritterbusch David , Lewin Wolf-Christian , Shumka Spase , Spirkovski Zoran , Ilik-Boeva Dusica , Brämick Uwe , Peveling Ralf 
Published: October 2022

Abstract
Greater Prespa Lake, located on the Balkan Peninsula, is an ancient freshwater lake inhabited by numerous endemic and endangered species and represents an important part of Europe’s natural heritage. Between 2013 and 2015, standardized gillnet fishing was conducted for the first time ever with the aim of obtaining large-scale information on the status of the fish community in terms of the relative abundance, biomass, and spatial distribution of the species occurring in the lake. Although 15 fish species were caught, the catches were numerically dominated by just five – the native Prespa roach (Leucos basak), Prespa bleak (Alburnus belvica), and Prespa spirlin (Alburnoides prespensis), and the non-indigenous bitterling (Rhodeus amarus) and topmouth gudgeon (Pseudorasbora parva). Overall, the non-indigenous fishes combined outnumbered the native species, while Prespa bleak, Prespa spirlin, Prespa roach, and bitterling accounted for the highest biomass proportions. The fish assemblages of the northeastern and southwestern basins were more similar to each other than to the fish communities at the other sampling sites. The results indicated that non-indigenous fishes have become well established in the lake within just 20 to 40 years of their initial introduction. Altogether, the current data provide a solid basis for the knowledge-based management of the aquatic resources of this precious freshwater body.
Effects of dietary yeast β-1.3/1.6-glucans on oxidative stress biomarkers in hearts and livers of rainbow trout (Oncorhynchus mykiss Walbaum), European whitefish (Coregonus lavaretus L.), and grayling (Thymallus thymallus L.)
Authors: Tkachenko Halyna , Grudniewska Joanna , Kurhaluk Natalia 
Published: October 2022

Abstract
The present study was performed to investigate the effects of dietary yeast β-1,3/1,6-D-glucans supplemented over a 14-day feeding period on liver and cardiac function and the oxidative mechanism underlying these effects. We assessed relevant lipid peroxidation and protein oxidation biomarkers, antioxidant defense indices [superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant capacity (TAC)], and biochemical alterations [activities of aminotransferases (AT), lactate dehydrogenase (LDH), and succinate dehydrogenase (SDH), and levels of lactate (L) and pyruvate (P)] in rainbow trout, European whitefish, and grayling. The fish received a control diet and an experimental diet containing yeast β-1,3/1,6-D-glucans at a dose of 1% in the basal feed for 14 days. The results demonstrated enhancement in the phagocytic activity and phagocytic index in the groups fed β-glucans, compared to the control groups. In the groups fed β-glucans, the oxidative stress parameters such as lipid peroxidation, oxidatively modified proteins, and TAC did not vary significantly. The dietary β-glucans stimulated CAT and GPx activities in hepatic and cardiac tissues in comparison to the control group; however, a reverse trend was observed in the GR activity in these tissues.
Historical Aspects and Test Characteristics of Eponymously Named Psychometric Tests by Women: The Period up to 1970
Authors: Yale Allison J. , Colaiezzi Angela E. , Tekiner Halil , Yale Steven H. 
Published: October 2022

Abstract

Background: Prior to 1970, women authored or co-authored a variety of eponymously named psychometric tests predominately in children and young adults with developmental and behavioral disorders. Gaps remain in understanding and appreciating the extent of their contributions to these psychometric tests.

Methods: Two authors adjudicated psychometric tests in the text, Tests in Print, to identify those eponymously named after women. To be eligible for this study, the psychometric test title must contain the name of a woman and be published prior to 1970. If a woman published more than one eponymously named test, the earliest one, if available, was chosen to be included in this study. A search for individual and a combination of related Medical Subject Headings (MeSH) keywords of the “name of the women author” and “name of the test” was performed using the Google web browser, PubMed, APA PsycNet, and APA PsycInfo from inception to August 1, 2021. Further papers were identified using bibliographic search from source papers and reference books.

Results: Three hundred eighty-six eponymously named psychometric tests were identified, with 124 (32%) of them named in whole or in part by or for a woman. Of these 124 psychometric tests, 93 represent unique women’s names. Before 1970, there were twenty-three (19%) eponymously named psychometric tests with women, with twenty-one (17%) representing unique women’s names.

Conclusion: These tests were published by women whereby they served either as a single author or in collaboration with others or their spouse. In the latter case, the woman’s name universally appeared after their husband’s name. In only a few cases, are these women’s names well-referenced in biographical source materials. These women made essential contributions to the development and revision of psychometric tests and the field of psychology in general.
The Gift of Counsel, Infused Prudence, and the Natural Law
Authors: O’Reilly O.P. Kevin E. 
Published: October 2022

Abstract
This article deals with the Gifts of the Holy Spirit, with infused prudence, and with the natural law. Prudence has an intimate connection both with the natural law and with the Gift of Counsel, and is thus pivotal to the argument made. In brief, it is argued that the Gift of Counsel perfects reason’s grasp of the demands of the natural law. This Gift, which proportions the believer to the instinctus of the Holy Spirit, guides him in all that pertains the attainment of ultimate beatitude. It does so, moreover, by actually enhancing human freedom rather than by undermining it. In order to make this argument, this article, in the first instance, turns to a treatment of the content of natural reasoning, dealing in particular with the primary and secondary precepts of the natural law.
Why does environmental uncertainty have a moderating effect on marketing performance? A comparative analysis of Indonesian and Thai service industries
Authors: Nuryakin  , Fatmawati Indah , Siriyota Kumpanat 
Published: October 2022

Abstract
This study examined CRM’s effect on marketing performance and customer focus strategies. It also investigates the moderating role of environmental uncertainty in the relationship between CRM and customer focus on marketing performance. A quantitative research approach was used with a sample of the service industry in two countries, Indonesia and Thailand. The analysis unit was the manager responsible for customer relations. The number of examined surveys amounted to 406, with a distribution of 200 respondents from Thailand and 206 — from Indonesia. The purposive sampling approach was used. The study results indicated that CRM had a positive effect on marketing performance and customer focus. The latter positively affected marketing performance. The study also found that environmental uncertainty strengthened the relationship between CRM and the customer focus on marketing.