bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance imaging features of prostatic stromal tumour of uncertain malignant potential
Authors: Liu Yi , Wu Jingyun , Shen Qi , Li Derun , He Zhisong , Zhou Liqun , Xiao Jiangxi 
Published: April 2022

AbstractIntroductionProstatic stromal tumours of uncertain malignant potential (STUMPs) are rare prostate tumours. The purpose of this study was to investigate the magnetic resonance imaging features of STUMPs.MethodsA total of 12 patients with STUMP confirmed with pathology who underwent MRI from 2012 to 2020 were retrospectively reviewed. Pathological characteristics including histopathology and immunohistochemistry were also recorded.ResultsAmong 12 STUMPs, the tumours were detected in the peripheral zone (41.7%[n = 5]) and transitional zone (58.3% [n = 7]) of the prostate. 8 cases (66.7%) were round shape. All lesions were well‐defined and compressed the adjacent structures but without signs of an invasion. Homogeneous T1WI and heterogeneous T2WI signals were observed in the STUMPs. The tumours were mainly composed of solid components, while intratumoral cystic change (58.3%[n = 7]) and haemorrhage (8.3%[n = 1]) were seen. 10 cases(83.3%) were seen as relatively high DWI signal, while 2 cases(16.7%) with no increase in DWI. The mean ADC value was 1.084 ± 0.193 (range: 0.864–1.489 × 10−3 mm2/s). STUMPs had heterogeneous enhancement, with persistent or gradual enhancement. In immunohistochemical staining, Vim, CD34, PR and SMA were positive in the majority of STUMPs.ConclusionMRI features of STUMP are presented as regular, well‐defined and isolated prostatic mass with intact pseudocapsule. The presence of heterogeneous T2WI signal, intratumoral cystic change, slightly low mean ADC value and persistent or gradual enhancement may help predict the STUMPs.
Selective Disclosure, Expertise Acquisition, and Price Informativeness*
Authors: Jorgensen Bjorn N. , Li Jing , Melumad Nahum D. 
Published: April 2022

ABSTRACTWe examine how a firm's disclosure‐audience policy affects investors' expertise acquisition and price informativeness in the market. We distinguish the investors' information advantage due to superior access from that due to superior ability to process information. We show that targeted selective disclosure to sophisticated investors may encourage greater expertise acquisition on the part of investors and lead to more informative prices than either public disclosure or untargeted selective disclosure, because the value of expertise is maximized if sophisticated investors gain exclusive information access at a relatively low cost. These results illuminate the persistence of private communications between investors and firms in the post–Regulation Fair Disclosure era and provide implications for regulators in addressing increasing concerns raised about the enforcement of Regulation Fair Disclosure.
Improving inferences and predictions of species environmental responses with occupancy data
Authors: Morán‐López Teresa , Ruiz‐Suarez Sofía , Aldabe Joaquín , Morales Juan Manuel 
Published: April 2022

Abstract

Occupancy models represent a useful tool to estimate species distribution throughout the landscape. Among them, MacKenzie et al.’s model (2002, MC), is frequently used to infer species environmental responses. However, the assumption that detection probability is homogeneous or fully explained by covariates may limit its performance. Species should be more easily observed at sites with a higher number of individuals. We simulated data following occupancy model (RN) that accounts for abundance‐driven heterogeneous detection and two variants with overdispersion in the detection probability and local abundances. Then, we compared the performance of the MC model against that of RN.

In addition to model misspecifications, insufficient information in data (i.e. infrequent detections) can limit our ability to detect existing effects with affordable sampling designs. To deal with this source of error, we extended RN approach to a community‐level joint species model (RN‐JSM), where species responses and detectability depended on their traits and phylogeny. Then, we tested RN‐JSM performance in simulated and out‐of‐sample field data.

High abundance‐driven heterogeneity in detection (i.e. common and secretive species) limited the ability of the MC model to quantify covariate effects; especially, when the number of visits was low. Both models (MC and RN), often failed to detect existing effects when data were overdispersed. Moreover, the RN model consistently lacked sufficient power when analysing data from uncommon species (even when simulations and model specifications perfectly matched). This problem was solved by our RN‐JSM, which yielded more precise and accurate estimates of species environmental responses. Increased accuracy in rare species held when the RN‐JSM was tested with real and out‐of‐sample datasets.

In the light of our results, we propose: (i) for common and secretive species analyse occupancy data with the RN model and prioritize revisiting sites; (ii) for species that may have overdispersed detectability or local abundances (e.g. with correlated behaviours or occurring in clusters), apply RN extensions that account for this extra‐variation (e.g. Poisson‐beta or zero‐inflated models). Finally, (iii) for uncommon species (mean abundances <1), whenever possible, gather data at the community level and apply joint species modelling techniques.
Impact of adolescent intermittent ethanol exposure in male and female rats on social drinking and neuropeptide gene expression
Authors: Towner Trevor T. , Papastrat Kimberly M. , Spear Linda P. , Varlinskaya Elena I. , Werner David F. 
Published: April 2022

AbstractBackgroundAlcohol use during adolescence can alter maturational changes that occur in brain regions associated with social and emotional responding. Our previous studies have shown that adult male, but not female rats demonstrate social anxiety‐like alterations and enhanced sensitivity to ethanol‐induced social facilitation following adolescent intermittent ethanol exposure (AIE). These consequences of AIE may influence adult social drinking in a sex‐specific manner.MethodsTo test the effects of AIE on social drinking, male and female Sprague‐Dawley rats exposed to water or ethanol (0 or 4 g/kg, intragastrically, every other day, between postnatal day [P] 25 and 45) were tested as adults (P72‐83) in a social drinking paradigm (30‐minute access to a 10% ethanol solution in supersac or supersac alone in groups of three same‐sex littermates across two 4‐day cycles separated by 4 days off). Social behavior was assessed during the last drinking session, along with assessment of oxytocin (OXT), oxytocin receptor (OXTR), vasopressin (AVP), and vasopressin receptors 1a and 1b (AVPR1a, AVPR1b) in the hypothalamus and lateral septum.ResultsMales exposed to AIE consumed more ethanol than water‐exposed controls during the second drinking cycle, whereas AIE did not affect supersac intake in males. AIE‐exposed females consumed less ethanol and more supersac than water‐exposed controls. Water‐exposed females drinking ethanol showed more social investigation and significantly higher hypothalamic OXTR, AVP, and AVPR1b gene expression than their counterparts ingesting supersac and AIE females drinking ethanol. In males, hypothalamic AVPR1b gene expression was affected by drinking solution, with significantly higher expression evident in males drinking ethanol than those consuming supersac.ConclusionsCollectively, these findings provide new evidence regarding sex‐specific effects of AIE on social drinking and suggest that the hypothalamic OXT and AVP systems are implicated in the effects of ingested ethanol on social behavior in a sex‐ and adolescent‐exposure‐dependent manner.
Shadow worlding: Chasing light in Yogyakarta
Authors: Luvaas Brent 
Published: April 2022

AbstractIn the era of social media and digital cameras, street photography, or the candid documentation of everyday life in public space, has seen a resurgence of interest worldwide. What draws people to the genre is its ability to transform the way they see and experience the spaces around them. Street photography, I argue here, is a mode of shadow worlding, a dynamic and collaborative place‐making practice in which the places being built are left deliberately inchoate and incomplete. Based on several weeks of participant observation among street photographers in two Indonesian cities, this article considers what happens when we begin to see and experience the way a street photographer does. I tell the story of several Indonesian street photographers, as well as describe my own experiences with street photography, to demonstrate the potential of the genre for reimagining and reworking our relationships with the cities we live in and the fieldsites we pass through.
Resveratrol reverses male reproductive damage in rats exposed to nicotine during the intrauterine phase and breastfeeding
Authors: Francisco Camila Monteiro , Fischer Leonardo Wensing , Vendramini Vanessa , de Oliva Samara Urban , Paccola Camila Cicconi , Miraglia Sandra Maria 
Published: April 2022

AbstractBackgroundNicotine leads to reproductive changes culminating in male infertility and subfertility. Resveratrol, a polyphenol, is a biological modulator. Sirtuin 1 (SIRT1) protein can positively act on male reproduction, and its expression can be affected by nicotine and modulated by resveratrol.ObjectivesThe capability of resveratrol to reverse the reproductive damage in adult male offspring, which was nicotine‐exposed during the intrauterine phase and breastfeeding, was investigated.Materials and methodsFour groups were established with male offspring born from nicotine‐exposed and non‐exposed rat dams during pregnancy and lactation. Forty‐eight male Wistar rats were distributed into four groups: sham control (SC), resveratrol (R), nicotine (N), and nicotine + resveratrol (NR). Rat dams of the N and NR offspring were exposed to nicotine (2 mg/kg/day) during pregnancy and lactation using a subcutaneously implanted minipump. The offspring of the R and NR groups received resveratrol (300 mg/kg of body weight, gavage) for 63 days from puberty. At 114 days of age, the male rats were euthanized.ResultsNicotine did not alter the body weight, biometry of reproductive organs, or quantitative sperm parameters of adult offspring but caused an evident worsening of all sperm qualitative parameters studied. Daily treatment with resveratrol from puberty up to adulthood improved all qualitative sperm parameters significantly, leading some of them close to the control values. Resveratrol also improved the morphological integrity and expression of SIRT1 in the seminiferous epithelium of nicotine‐exposed offspring.Conclusion and DiscussionResveratrol reversed the male reproductive damage caused by nicotine. Nicotine crosses the blood‐placental membrane and is present in the breast milk of mothers who smoke. Resveratrol restored the altered reproductive parameters in the male adult offspring that were nicotine‐exposed during intrauterine life and breastfeeding. The epigenetic modulating action of resveratrol can be involved in this nicotine damage reversion. Resveratrol may be a promising candidate to be investigated regarding the adjuvant strategies in the treatment of male infertility.
An integrative approach to more nuanced estimates of personality–job–performance relations
Authors: Wihler Andreas , Blickle Gerhard , Ewen Christian , Genau Hanna , Fritze Sonja , Völkl Lena , Merkl Roxanne , Missfeld Tamara , Mützel Melanie 
Published: April 2022

AbstractRecent research has suggested that self‐ and other‐ratings of personality may provide different information about personality, which can be captured in the trait–reputation–identity (TRI) model. Based on the TRI model, we investigate the link between personality and aligned job performance criteria on domain and aspect levels of the Big Five personality traits. In five samples (overall N = 571 triplets of target self‐ratings and two coworker other‐ratings), we investigated the relationships between the shared information on personality and shared information about job performance. We found that all personality domains showed substantial criterion validity in predicting the corresponding job‐performance dimensions. Furthermore, we found stronger estimates for aspects of agreeableness and openness. We discuss theoretical and practical implications for target replacement and performance management.
In a no‐win situation: The employment–health dilemma
Authors: Kößler Franziska J. , Wesche Jenny S. , Hoppe Annekatrin 
Published: April 2022

AbstractWork and organizational psychology (WOP) research has to date mostly focused on people privileged to have the choice between several attractive job options and less on people who are restricted in their job choice (e.g., due to their qualification or personal contingencies) and have to choose from fewer and often less‐than‐optimal jobs. Often, the jobs available to the latter are characterized by precarious employment and hazardous working conditions which can put them in the difficult situation of having to choose between a health‐threatening job and possible unemployment. Building on interdisciplinary literature, we propose the employment–health dilemma (E‐H dilemma) as a framework for analyzing this intrapersonal conflict of having to choose between employment (incurring health threats) and health (incurring economic threats) and discuss potential antecedents and consequences of the E‐H dilemma at the societal, organizational, and individual level. We outline the implications of the E‐H dilemma and make a case for examining the full spectrum of job choice situations in WOP research. In doing so, we demonstrate what WOP can gain by embracing a more inclusive and multidisciplinary approach: uncovering processes in their entirety (e.g., job choice decisions of all people) and strengthening the role and legitimacy of WOP in society.
Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults
Authors: Talley Nicholas J. , Holtmann Gerald J. , Southwell Bridget R. , Fisher David , Koloski Natasha A. , Jones Michael 
Published: April 2022

LINKED CONTENTThis article is linked to Sharma et al papers. To view these articles, visit https://doi.org/10.1111/apt.16369 and https://doi.org/10.1111/apt.16910
Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults. Authors’ reply
Authors: Sharma Amol , Rao Satish 
Published: April 2022

LINKED CONTENTThis article is linked to Sharma et al papers. To view these articles, visit https://doi.org/10.1111/apt.16369 and https://doi.org/10.1111/apt.16877
Editorial: choosing the optimal screening method for latent TB in patients with IBD commencing anti‐TNF‐therapy—authors' reply
Authors: Kumar Peeyush , Vuyyuru Sudheer Kumar , Kedia Saurabh , Ahuja Vineet 
Published: April 2022

LINKED CONTENTThis article is linked to Kumar et al papers. To view these articles, visit https://doi.org/10.1111/apt.16839 and https://doi.org/10.1111/apt.16878
Relationship of parathyroid hormone‐related protein and neonatal mineral metabolism in dairy cow placentas
Authors: Kazama Kei , Nishio Takuma , Nagane Masaki , Arai Sachiko , Onda Ken 
Published: April 2022

AbstractParathyroid hormone‐related protein (PTHrP) plays essential roles in placental calcium (Ca) transport, and it has been speculated that PTHrP in the placenta is regulated by calcium‐sensing receptors (CaSR). This study clarified the relationship between PTHrP in the placenta of dairy cows and minerals in the fetal blood. Blood samples were obtained from 21 Holstein cows and 17 neonatal calves as well as 12 umbilical veins and arteries during cesarean section. After fetus removal, 13 caruncles and cotyledons were obtained. Concentrations of plasma PTHrP and serum minerals were measured. Real‐time polymerase chain reaction (RT‐qPCR) analyzed the gene expression of PTHrP and CaSR in the placenta. As a result, serum Ca and inorganic phosphorus concentrations in the neonate, umbilical vein, and artery were significantly higher than in the mother. Additionally, plasma PTHrP was detected in the bovine neonatal jugular vein, umbilical artery, and vein. PTHrP gene expression was significantly higher in the caruncles than in cotyledons; however, CaSR gene expression was higher in the cotyledons than in caruncles. These findings suggest that the PTHrP obtained from the placenta influences Ca homeostasis in the bovine fetus.
Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5
Authors: Zhang Qingqing , Yang Ruiying , Tian Yizhen , Ge Suyin , Nan Xiaojuan , Zhu Shihao , Dong Shuhong , Zhang Baolai 
Published: April 2022

AbstractProtein arginine methyltransferases 1 and 5 (PRMT1 and PRMT5) are frequently overexpressed in diverse types of cancers and correlate with poor prognosis, thus making these enzymes potential therapeutic targets. The aim of this study was to assess and elucidate the anti‐tumour effect and epigenetic regulatory mechanism of ribavirin in soft tissue sarcomas (STS). We showed that ribavirin inhibited growth and metastasis and prolonged survival in animals bearing STS cells by downregulating the mRNA and protein levels of PRMT1/PRMT5 and attenuating the accumulation of asymmetric and symmetric di‐methylation of arginine (ADMA and SDMA). Furthermore, ribavirin lowered the permeability of the peritoneum in KM mice bearing S180 ascites via decreasing the level of vascular endothelial growth factor (VEGF). Ribavirin was a potent inhibitor of cell proliferation and metastasis in STS cells through downregulation of both type I PRMT1 and type II PRMT5. Ribavirin could be used to enhance the efficacy of doxorubicin in STS allograft tumour models.
METTL3‐m6A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway
Authors: Wu Tianli , Tang Hui , Yang Jianghua , Yao Zhihao , Bai Long , Xie Yuping , Li Qing , Xiao Jingang 
Published: April 2022

AbstractObjectivesBone marrow mesenchymal stem cells (BMSCs) hold a high osteogenic differentiation potential, but the mechanisms that control the osteogenic ability of BMSCs from osteoporosis (OP‐BMSCs) need further research. The purpose of this experiment is to discuss the osteogenic effect of Mettl3 on OP‐BMSCs and explore new therapeutic target that can enhance the bone formation ability of OP‐BMSCs.Materials and MethodsThe bilateral ovariectomy (OVX) method was used to establish the SD rat OP model. Dot blots were used to reveal the different methylation levels of BMSCs and OP‐BMSCs. Lentiviral‐mediated overexpression of Mettl3 was applied in OP‐BMSCs. QPCR and WB detected the molecular changes of osteogenic‐related factors and Wnt signalling pathway in vitro experiment. The staining of calcium nodules and alkaline phosphatase detected the osteogenic ability of OP‐BMSCs. Micro‐CT and histological examination evaluated the osteogenesis of Mettl3 in OP rats in vivo.ResultsThe OP rat model was successfully established by OVX. Methylation levels and osteogenic potential of OP‐BMSCs were decreased in OP‐BMSCs. In vitro experiment, overexpression of Mettl3 could upregulate the osteogenic‐related factors and activate the Wnt signalling pathway in OP‐BMSCs. However, osteogenesis of OP‐BMSCs was weakened by treatment with the canonical Wnt inhibitor Dickkopf‐1. Micro‐CT showed that the Mettl3(+) group had an increased amount of new bone formation at 8 weeks. Moreover, the results of histological staining were the same as the micro‐CT results.ConclusionsTaken together, the methylation levels and osteogenic potential of OP‐BMSCs were decreased in OP‐BMSCs. In vitro and in vivo studies, overexpression of Mettl3 could partially rescue the decreased bone formation ability of OP‐BMSCs by the canonical Wnt signalling pathway. Therefore, Mettl3 may be a key targeted gene for bone generation and therapy of bone defects in OP patients.
A literature review of liver function test elevations in rifampin drug–drug interaction studies
Authors: Ibrahim Sherry M. , Pithavala Yazdi K. , Vourvahis Manoli , Chen Joseph 
Published: April 2022

AbstractAlthough rifampin drug–drug interaction (DDI) studies are routinely conducted, there have been instances of liver function test (LFT) elevations, warranting further evaluation. A literature review was conducted to identify studies in which combination with rifampin resulted in hepatic events and evaluate any similarities. Over 600 abstracts and manuscripts describing rifampin DDI studies were first evaluated, of which 30 clinical studies reported LFT elevations. Out of these, 11 studies included ritonavir in combination with other drug(s) in the rifampin DDI study. The number of subjects that were discontinued from treatment on these studies ranged from 0 to 71 (0–100% of subjects in each study). The number of subjects hospitalized for adverse events in these studies ranged from 0 to 41 (0–83.67% of subjects in each study). LFT elevations in greater than 50% of subjects were noted during the concomitant administration of rifampin with ritonavir‐boosted protease inhibitors and with lorlatinib; with labeled contraindication due to observed hepatotoxicity related safety findings only for saquinavir/ritonavir and lorlatinib. In the lorlatinib and ritonavir DDI studies, considerable LFT elevations were observed rapidly, typically within 24–72 h following co‐administration. A possible sequence effect has been speculated, where rifampin induction prior to administration of the combination may be associated with increased severity of the LFT elevations. The potential role of rifampin in the metabolic activation of certain drugs into metabolites with hepatic effects needs to be taken into consideration when conducting rifampin DDI studies, particularly those for which the metabolic profiles are not fully elucidated.
A review of literature on history education: An analysis of the conceptual, intellectual and social structure of a knowledge domain (2000–2019)
Authors: Gómez‐Carrasco Cosme J. , Rodríguez‐Medina Jairo , López‐Facal Ramón , Monteagudo‐Fernández José 
Published: April 2022

AbstractIn recent decades, Historical Thinking and Historical Consciousness have been two fundamental axes of research in history education. The first approach combines the use of historical sources and the work of the historian. The second includes the social function of history, identity, memory and civic and moral education. These two approaches attempt to provide students with the necessary intellectual tools for analysing the past and relating it to an understanding of problems in the present time. This article reviews the development and shaping of the knowledge domain of history education between 2000 and 2019 in the WoS (Web of Science). To this end, several techniques and tools were used, including R‐package Bibliometrix and VOSviewer. Our analysis identifies five clusters of topics underpinning history education as a specific field of knowledge. This review highlights the fact that research topics associated with Historical Thinking and Historical Consciousness have gradually acquired a more central role to the detriment of History Textbooks or topics generally related to History. Finally, we describe how the term History Educationfunctions as a marker for this knowledge domain.