bluuebunny/crossref_metadata_2025_split huggingface dataset:
Langerhans cell histiocytosis of the uvea with a ciliochoroidal mass: a Case report of management with systemic therapy
Authors: Mahdizad Zahra , Riazi-Esfahani Hamid , Ebrahimiadib Nazanin , Amini Abdulrahim , Ghassemi Fariba 
Published: February 2022

Abstract
Background. This study aims to explore a case of choroidal Langerhans cell histiocytosis (LCH) successfully treated with systemic corticosteroid and immunosuppressant. Case presentation. A 24-year-old man with known multisystem LCH developed loss of vision, ocular pain, conjunctival injection, panuveitis, and a ciliochoroidal mass. After receiving an intravenous methylprednisolone pulse, oral high-dose corticosteroids, and methotrexate, the mass resolved quickly and completely without flare-ups during 6 months of follow-up.Conclusions. Intraocular involvement of LCH is rare and can present with or without a history of multisystemic disease. The diagnosis is challenging and the standard treatment is not established. Systemic anti-inflammatory and immunosuppressive therapy could be an effective treatment, as the LCH itself contains an essential element of inflammation and the symptoms may be mainly inflammatory.
Oxalate Nephropathy in a Patient with COVID-19- Infection: Causation or Association
Authors: Kannan Lakshmi , Raj Rishi , Abbasi Sheharyar , Jacob Aasems 
Published: February 2022

Abstract
The pandemic due to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV2) has led to significant morbidity and mortality over the last two years. Although lungs are the primarily involved organ with infection due to COVID-19, there have been rising rates of COVID-19 related kidney disease. Kidney injury among patients with COVID-19 can present in multiple ways, and different pathophysiologic mechanisms have been suggested. We describe a case of an elderly woman who developed acute kidney injury secondary to oxalate nephropathy in the setting of severe COVID-19 infection and needed hemodialysis. Our case illustrates that calcium oxalate crystal deposition in the kidney (oxalate nephropathy) could be one of the possible pathophysiologic mechanisms of renal dysfunction in the setting of COVID-19.
Headache in Hemangioblastomas : A Histopathology and Structural
Authors: AN Arabestani , A Ai , SS Naghibhi Irvani , M Mahmoodi , MT Chaboki 
Published: February 2022

Abstract
Hemangioblastoma (HBL) are rare, benign, s highly vascularized tumor of not well-defined histological origin. highly vascularized tumors that can be found throughout the neuraxis but are mainly located in the cerebellum and in the spinal cord. the most common primary tumor of the posterior fossa in adults. Hemangioblastomas may also occur within the spine. Single tumors may be sporadic, but multiple tumors are almost always associated with von Hippel-Lindau (VHL) disease. Sporadic tumors appear in the fifth and sixth decades of life, whereas VHL-associated tumors are detected earlier, in the third and fourth decades. One-third of patients with cerebellar hemangioblastoma have VHL disease. Two-thirds of VHL patients develop hemangioblastomas; thus screening and surveillance programs are required for this population. This meta-analysis was performed to evaluate headache in Hemangioblastoma (HBL) tumors structurally and separately based on randomized controlled trial studies. Electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) were searched for randomized and controlled trial studies that searched for the results of treatment of brain tumors (Hemangioblastoma type) and headache in Hemangioblastoma (HBL) tumors. This meta-analysis was performed using Review Manager (RevMan) software (version 5.2) provided by Cochrane Collaboration. The data used were hazard ratios with 95% confidence intervals calculated for time-to-event data extracted from survival curves and local tumor control rate curves. A consecutive series of patients with hemangioblastomas on between 1985 and 2010 by the senior author (A.AN) is Reviewed. The functional scale proposed by McCormick was used to evaluate the patients’ neurological status before and after surgery. Adequate knowledge for the treatment and correct use of microsurgical techniques allows complete resection of these tumors with minimal complications and maximum functional improvement. The result appears to be directly related to the preoperative condition.
Circadian Disruption Alters Gut Barrier Integrity via A ß-Catenin-MMP-Related Pathway
Authors: Eum Sung Yong , Schurhoff Nicolette , Wolff Gretchen , Toborek Michal 
Published: February 2022

Abstract
We evaluated the mechanistic link between circadian rhythms and gut barrier permeability. Mice were subjected to either constant 24-hour light (LL) or 12-hour light/dark cycles (LD). Mice housed in LL experienced a significant increase in gut barrier permeability that was associated with dysregulated ß-catenin expression and altered expression of tight junction (TJ) proteins. Silencing of ß-catenin resulted in disruption of barrier function in SW480 cells, with ß-catenin appearing to an upstream regulator of Bmal1 and Clock. In addition, ß-catenin silencing downregulated ZO-1 and occludin TJ proteins with only limited or no changes at their mRNA levels, suggesting post transcriptional regulation. Indeed, silencing of ß-catenin significantly upregulated expression of matrix metallopeptidase (MMP)-2 and MMP-9, and blocking MMP-2/9 activity attenuated epithelial disruption induced by ß-catenin silencing. These results indicate the regulatory role of circadian disruption on gut barrier integrity and the associations between TJ proteins and circadian rhythms, while demonstrating the regulatory role of ß-catenin in this process.
The importance of sustained compliance with physical distancing during COVID-19 vaccination rollout
Authors: Teslya Alexandra , Rozhnova Ganna , Pham Thi Mui , Wees Daphne van , Nunner Hendrik , Godijk Noortje , Bootsma Martin , Kretzschmar Mirjam 
Published: February 2022

Abstract
Background: The increasing vaccination coverage against SARS-CoV-2 enabled relaxation of lockdowns in many countries. The public health authorities are seeking recommendations on the continuation of physical distancing measures during ongoing vaccination rollouts. Compliance with these measures is waning while more transmissible virus variants have emerged.

Methods: We used a SARS-CoV-2 transmission model to investigate the feedback between compliance, infection incidence, and vaccination coverage. We quantified our findings in terms of cumulative numbers of new infections three and six months after the start of vaccination.

Results: Our results suggest that the combination of fast waning compliance in non-vaccinated individuals, low compliance in vaccinated individuals, low vaccine efficacy against infection and more transmissible virus variants may result in a higher cumulative number of new infections than in a situation without vaccination. These adverse effects can be alleviated by deploying behavioural interventions that should preferably target both vaccinated and non-vaccinated individuals. The choice of the most appropriate intervention depends on vaccination rate and vaccine efficacy again infection.

Conclusion: Supplementary behavioural interventions aiming to boost compliance to physical distancing measures can improve the outcome of SARS-CoV-2 vaccination programmes, until vaccination coverage is suffciently high. For optimal results, these interventions should be selected based on the vaccine efficacy against infection and expected vaccination rate.
Development and Validation of A Practical Machine-Learning Triage Algorithm for The Detection of Patients in Need of Critical Care in The Emergency Department
Authors: Liu Yecheng , Gao Jiandong , Liu Jihai , Walline Joseph Harold , Liu Xiaoying , Zhang Ting , Wu Ji , Zhu Huadong , Zhu Weiguo 
Published: February 2022

Abstract
Background
One of the great challenges in the emergency department (ED) is to accurately differentiate critically ill from stable patients. Although there are many triage systems in the world, these all rely to varying degrees on the subjective judgment of triage officers, which may contribute to mis-triage errors. To accurately differentiate critically ill from stable patients, we present a machine learning system (MLS) that can provide a second opinion to ED triage officers to help recognize critically ill patients. The system also provides individual explanations, visible to triage officers, as to why a patient scored the way they did.
Methods
To derive the MLS, an existing dataset of 22,272 patient encounters from 2012 to 2019 from our institution’s electronic emergency triage system (EETS) was used for algorithm training. Once the MLS was derived, we conducted a prospective randomized cohort study of ED patients between March and April 2020. The mis-triage rate (defined as a patient initially triaged to a EETS level 3 or 4 acuity that was then up-triaged or taken to the resuscitation room) was calculated with and without the input of the MLS.
Results
The MLS system achieved an area under the receiver operating characteristic curve (AUC) value of 0.86 in a retrospective validation dataset of 2,000 cases. In the prospective cohort study, compared to the traditional triage system’s 1.2% mis-triage rate in the control group, the mis-triage rate in the MLS-assisted group was 0.9%.
Conclusion
This MLS method with a real-time practical explanation for triage officers was able to lower the mis-triage rate of ED patients in need of critical care.
Quantitative CT analysis to predict esophageal fistula in patients with advanced esophageal cancer treated by chemotherapy or chemoradiotherapy
Authors: Sun Ying-Shi , Shi Yan-Jie , Liu Chang , Wei Yi-Yuan , Li Xiao-Ting , Tang Lei , Shen Lin , Lu Zhi-Hao 
Published: February 2022

Abstract
Background: Esophageal fistula is one of the most serious complications of chemotherapy or chemoradiotherapy (CRT) for advanced esophageal cancer. This study aimed to evaluate the performance of quantitative computed tomography (CT) analysis and to establish a practical imaging model for predicting esophageal fistula in esophageal cancer patients administered chemotherapy or chemoradiotherapy. Methods: This study retrospectively enrolled 204 esophageal cancer patients (54 patients with fistula, 150 patients without fistula) and all patients were allocated to the test and validation cohorts according to the time of inclusion in a 1:1 ratio. Ulcer depth, tumor thickness and length, and minimum and maximum enhanced values for esophageal cancer were measured in pretreatment CT imaging. Logistic regression analysis was used to evaluate the associations of CT quantitative measurements with esophageal fistula. Receiver operating characteristic curve (ROC) analysis was also used. Results: Logistic regression analysis showed that independent predictors of esophageal fistula included tumor thickness [odds ratio (OR)=1.167; p = 0.037], the ratio of ulcer depth to adjacent tumor thickness (OR=164.947; p < 0.001), and the ratio of minimum to maximum enhanced CT value (OR=0.006; p = 0.039) in the test cohort at baseline CT imaging. These predictors were used to establish a predictive model for predicting esophageal fistula, with areas under the receiver operating characteristic curves (AUCs) of 0.946 and 0.841 in the test and validation groups, respectively. Conclusions: Quantitative pretreatment CT analysis has excellent performance for predicting fistula formation in esophageal cancer patients who treated by chemotherapy or chemoradiotherapy.
A Preliminary Comparative Study of Prenatal Screening and Postpartum Anatomy Using a Novel Improved Cardiovascular Model Based on Literature Data
Authors: ANN PENG , WANG ZHONGQIU 
Published: February 2022

Abstract
Background: To study the molding method for twenty fetal complex cardiovascular malformation models (CCMM) and its significance in prenatal diagnosis and teaching.Methods: The modified vascular anatomical molding method was used to cast the micro blood vessels and trachea of twenty specimens diagnosed with complex congenital heart disease. Subsequently, twenty abnormal vascular models of the fetal aorta, pulmonary artery and other branches were analyzed and compared with the prenatal ultrasound to summarize their characteristics and misdiagnosis. Results: It was observed that all twenty cases of the fetuses were confirmed with complex cardiac malformations. A total of 69 cardiac malformations were recorded, among which 7 cases were misdiagnosed using prenatal echocardiography (including 3 cases of the interrupted aortic arch (IAA) and 3 cases of double outlet right ventricle (DORV) with transposition of the great arteries (TGA) confirmed by CCMM, case 5.12.14.15.16.17.18), and 18 were missed by prenatal echocardiography (including 5 cases of abnormal ductus arteriosus, 1 case of infrahepatic interruption of the inferior vena cava (IIVC), 1 case of the right aortic arch with mirror-image branching (RAMI), and 3 cases of aberrant subclavian artery (ASA), All cases except 5.8). Conclusion: There are many different kinds of abnormalities in the fetal aorta, pulmonary artery and other branches, which are often complicated with intracardiac malformation and arterial/venous branch variation. Prenatal echocardiography has important diagnostic value; a vascular model can directly show its characteristic changes, which is helpful to improve the differential diagnosis of complex congenital heart disease. Our findings prove that CCMM can play an important role in the clinics, scientific research, teaching, and popular cardiovascular science. Furthermore, it can promote the development of fetal cardiac surgery and the diagnosis with medical imaging and the teaching of medical theory.
A novel medium- and long-term runoff combined forecasting model based on different lag periods
Authors: Ai Ping , Song Yanhong , Xiong Chuansheng , Chen Binbin , Yue Zhaoxin 
Published: February 2022

Abstract
The accuracy of medium- and long-term runoff forecasting plays a signiﬁcant role in several applications involving the management of hydrological resources, such as power generation, water supply and ﬂood mitigation. Numerous studies that adopted combined forecasting models to enhance runoff forecasting accuracy have been proposed. Nevertheless, some models do not take into account the effects of different lag periods on the selection of input factors. Based on this, this paper proposed a novel medium- and long-term runoff combined forecasting model based on different lag periods. In this approach, the factors are initially selected by the time-delay correlation analysis method of different lag periods and further screened with stepwise regression analysis. Next, an extreme learning machine (ELM) is adopted to integrate each result obtained from the three single models, including multiple linear regression (MLR), feed-forward back propagation-neural network (FFBP-NN) and support vector regression (SVR), which is optimized by particle swarm optimization (PSO). To verify the effectiveness and versatility of the proposed combined model, the Lianghekou and Jinping hydrological stations from the Yalong River basin, China, are utilized as case studies. The experimental results indicate that compared with MLR, FFBP-NN, SVR and ridge regression (RR), the proposed combined model can better improve the accuracy of medium- and long-term runoff forecasting in the statistical indices of MAE, MAPE, RMSE, DC, U95 and reliability.
The effects of the music intervention on anxiety, pain, vital signs, and patient satisfaction in intravitreal injection: a randomized controlled study
Authors: HIZ Mustafa , CİĞERCİ Yeliz , DOĞAN Mustafa 
Published: February 2022

Aim: This study aimed to investigate the effects of music intervention applied in two different periods Before intravitreal injection (IVTI) on anxiety, pain perception, vital signs, andsatisfaction in patients receiving intravitreal injection..Methods: This randomized controlled study was conducted with a total of three groups including two music intervention groups (pre-IVTI (group 1) and during IVTI (group 2)) and acontrol group (Group 1 n= 73, Group 2 n = 74, Control Group n =72). The patients’ pain was evaluated with the Visual Analog Scale (VAS) pain, anxiety with the Visual Analog ScaleAnxiety (VAS-A), and satisfaction with the IVTI procedure with a 5-point Likert scale. Results: The anxiety and pain scores were lower in groups 1 and 2 than in the control group (p&lt;0.001). All three groups had low pain levels when their VAS-Pain scores were compared immediately and 15 minutes after IVTI. Group 2 was found to have a significant difference between the two measurements (pb =0.009). Further, Groups 1 and 2 had significantly higher patient satisfaction with the IVTI procedure than the control group (p&lt;0.001).Conclusion: The study results showed that music intervention has positive effects on anxiety, pain perception, and satisfaction in patients receiving IVTI therapy. As a result, we recommend the use of listening to music on patients before and during the IVTI procedure.
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease
Authors: Farzipour Soghra , Shaghaghi Zahra , Motieian Shokouh , Alvandi Maryam , Yazdi Amirhossein , Asadzadeh Bahareh , Abbasi Sahar 
Published: February 2022

Abstract:
Ferroptosis is a novel form of programmed cell death that occurs due to an increase in iron levels. Ferroptosis is implicated in a number of cardiovascular diseases, including myocardial infarction (MI), reperfusion damage, and heart failure (HF). As cardiomyocyte depletion is the leading cause of patient morbidity and mortality, it is critical to thoroughly comprehend the regulatory mechanisms of ferroptosis activation. In fact, inhibiting cardiac ferroptosis can be a useful therapeutic method for cardiovascular disorders. The iron, lipid, amino acid, and glutathione metabolisms strictly govern the beginning and execution of ferroptosis. Therefore, ferroptosis can be inhibited by iron chelators, free radical-trapping antioxidants, GPX4 (Glutathione Peroxidase 4) activators, and lipid peroxidation (LPO) inhibitors. However, the search for new molecular targets for ferroptosis is becoming increasingly important in cardiovascular disease research. In this review, we address the importance of ferroptosis in various cardiovascular illnesses, provide an update on current information regarding the molecular mechanisms that drive ferroptosis, and discuss the role of ferroptosis inhibitors in cardiovascular disease.
Evaluasi Kinerja Bangunan Rumah Sakit Santa Maria Pemalang dengan Non-linier Static Pushover Analysis Metode ATC-40 dan FEMA 440
Authors: Hutama Bima Priya 
Published: February 2022

ABSTRACTThe study of this final assignment was conducted by evaluating the earthquake-resistant performance of Santa Maria Hospital Structure in Pemalang to figure out the building’s performance level based on the methods of ATC-40 and FEMA 440, as well as to find out the mechanism of formed plastic joints on the beam-column and to predict the collapse behavior. The research method used a response spectrum using a SAP2000v19 program. Based on ATC-40, performance point values for x-direction and y-direction were 0.00433 and 0.00408. Those results show that the reviewed building structure categorized in the performance level of Immediate Occupancy (IO). Meanwhile, the analysis of structure damage level using FEMA 440 has resulted values for structure’s lateral displacement target of x-direction was 0.17819 m and y-direction of 0.13524 m, and categorized in the performance level of Immediate Occupancy (IO). Most of the plastic joint level on the beam and column has been categorized in the Immediate Occupancy (IO). In this category, it can be said that the performance of structure components are still in secured condition when displacement target achieved. ABSTRAKPenelitian ini dilakukan dengan mengevaluasi kinerja tahanan gempa Gedung Rumah Sakit Santa Maria Pemalang untuk mengetahui level kinerja bangunan (performance level) berdasarkan metode ATC-40 dan FEMA 440. Serta mekanisme terbentuk sendi plastis pada balok kolom dan memprediksi perilaku keruntuhan. Metode penelitian menggunakan respons spektrum dengan program SAP2000v19. Berdasarkan ATC-40 diperoleh nilai performance point untuk arah x = 0,00433 dan arah y =0,00408. Hasil tersebut menunjukkan bahwa struktur gedung yang ditinjau termasuk dalam tingkat kinerja Immediate Occupancy (IO). Sedangkan hasil analisis tingkat kerusakan struktur menggunakan FEMA 440 menghasilkan nilai target perpindahan lateral struktur arah x = 0,17819 m, dan arah y = 0,13524 m dan termasuk dalam kategori tingkat kinerja struktur Immediate Occupancy (IO). Sebagian besar tingkat sendi plastis balok dan kolom masih dalam Immediate Occupancy (IO). Dalam kategori ini dapat dikatakan kinerja komponen struktur masih dalam keadaan aman saat target perpindahan tercapai.
Evaluasi Kenyamanan Termal Ruang Kuliah IKIP PGRI Wates Kulon Progo DIY
Authors: Sativa Sativa - , Adilline Putri Salsa 
Published: February 2022

ABSTRACTThermal comfort is one of the factors that affect the comfort level of the occupants of the room, because if it is not up to standard it can reduce work productivity. This study was conducted to find out how the thermal conditions of the lecture hall at the IKIP PGRI Wates Yogyakarta campus were. This study uses a quantitative descriptive method. The data was obtained through field observations to obtain the value of air temperature, wind speed, humidity, and the value of hourly air change (ACH). The data from the measurement and calculation analysis were then compared with the standards of SNI 03-6572-2001 and EnREI 1991. This study found that: (1) the percentage of ventilation openings met the standard of SNI O3-6572-2001, (2) the thermal comfort index which includes air temperature, wind speed, humidity, and ACH do not meet the standards of thermal comfort according to SNI 03-6572-2001 and EnREI 1991, (3) there are differences in the values of air temperature, humidity, and wind speed between open and closed windows. To support maximum air flow, it is recommended that the window opening type be replaced with a casement side hung type. In addition, the outlet opening on the east side can be added with curtains to reduce solar radiation which can increase air temperature. ABSTRAKKenyamanan termal adalah salah satu faktor yang berpengaruh pada tingkat kenyamanan penghuni ruangan, karena jika tidak sesuai standar dapat mengurangi produktivitas kerja. Kajian ini dilakukan untuk mengetahui bagaimana kondisi termal ruang kuliah Kampus IKIP PGRI Wates Yogyakarta. penelitian ini menggunakan metode deskriptif kuantitatif. Data diperoleh melalui observasi lapangan untuk mendapatkan nilai temperatur udara, kecepatan angin, kelembapan udara, serta nilai pergantian udara per jam (ACH). Data hasil pengukuran dan analisis perhitungan kemudian dibandingkan dengan standar SNI 03-6572-2001 dan EnREI 1991. Studi ini menemukan bahwa: (1) prosentase bukaan ventilasi ruang telah memenuhi standar SNI O3-6572-2001, (2) indeks kenyamanan termal yang meliputi temperatur udara, kecepatan angin, kelembapan udara, dan ACH belum memenuhi standar kenyamanan termal sesuai SNI 03-6572-2001 dan EnREI 1991, (3) terdapat perbedaan nilai temperatur udara, kelembapan udara, dan kecepatan angin antara jendela terbuka dan jendela tertutup. Untuk mendukung agar aliran udara lebih maksimal, disarankan tipe bukaan jendela diganti dengan tipe casement side hung. Selain itu, bukaan outlet pada sisi timur dapat ditambahkan tirai untuk mengurangi radiasi matahari yang dapat meningkatkan suhu udara.