bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison Between First Line Target Therapy and Immunotherapy in Different Prognostic Categories of BRAF Mutant Metastatic Melanoma Patients: An Italian Melanoma Intergroup Study
Authors: Marconcini Riccardo , Fava Paolo , Nuzzo Amedeo , Manacorda Simona , Ferrari Marco , De Rosa Francesco , De Tursi Michele , Tanda Enrica Teresa , Consoli Francesca , Minisini Alessandro , Pimpinelli Nicola , Morgese Francesca , Bersanelli Melissa , Tucci Marco , Saponara Maristella , Parisi Alessandro , Ocelli Marcella , Bazzurri Serena , Massaro Giulia , Morganti Riccardo , Ciardetti Isabella , Stanganelli Ignazio 
Published: August 2022

BackgroundBRAF and MEK inhibitors target therapies (TT) and AntiPD1 immunotherapies (IT) are available first-line treatments for BRAF v600 mutant metastatic melanoma patients. ECOG PS (E), baseline LDH (L), and baseline number of metastatic sites (N) are well-known clinical prognostic markers that identify different prognostic categories of patients. Direct comparison between first-line TT and IT in different prognostic categories could help in first line treatment decision.MethodsThis is a retrospective analysis conducted in 14 Italian centers on about 454 metastatic melanoma patients, divided in 3 groups: group A—patients with E = 0, L within normal range, and N less than 3; group B—patients not included in group A or C; group C—patients with E &gt; 0, L over the normal range, and N more than 3. For each prognostic group, we compared TT and IT in terms of progression free survival (PFS), overall survival (OS), and disease control rate (DCR).ResultsIn group A, results in 140 TT and 36 IT-treated patients were, respectively, median PFS 35.5 vs 11.6 months (HR (95% CI) 1.949 (1.180–3.217) p value 0.009); median OS not reached vs 55 months (HR (95% CI) 1.195 (0.602–2.373) p value 0.610); DCR 99% vs 75% p value &lt;0.001). In group B, results in 196 TT and 38 IT-treated patients were, respectively, median PFS 11.5 vs 5 months (HR 1.535 (1.036–2.275) p value 0.033); median OS 19 vs 20 months (HR 0.886 (0.546–1.437) p value 0.623); DCR 85% vs 47% p value &lt;0.001). In group C, results in 41 TT and 3 IT-treated patients were, respectively, median PFS 6.4 vs 1.8 months (HR 4.860 (1.399–16) p value 0.013); median OS 9 vs 5 months (HR 3.443 (0.991–11.9) p value 0.052); DCR 66% vs 33% p value 0.612).ConclusionsIn good prognosis, group A—TT showed statistically significant better PFS than IT, also in a long-term period, suggesting that TT can be a good first line option for this patient category. It is only in group B that we observed a crossing of the survival curves after the 3rd year of observation in favor of IT. Few patients were enrolled in group C, so few conclusions can be made on it.
MULTI-BAND PATCH ANTENNA BASED ON ACTIVE METAMATERIAL
Authors: Ищенко Е.А. , Пастернак Ю.Г. , Пендюрин В.А. , Фёдоров С.М. 
Published: August 2022

Рассматривается конструкция планарной патч-антенны с активным метаматериалом, который позволяет путем подключения дополнительных слоев управлять рабочим диапазоном антенны. Благодаря применению конструкции такой антенны удалось достичь того, что прямоугольная патч-антенна обладает четырьмя режимами работы, которые обеспечивают четыре рабочих частотных диапазона антенны. При этом во всех режимах работы антенны сохраняются стабильные характеристики, так, коэффициент полезного действия не снижался менее 72%, коэффициент направленного действия антенны не ниже 7.2 дБ. Благодаря таким характеристикам можно сказать, что использование активного метаматериала в планарных антеннах позволяет улучшить характеристики антенны путем увеличения числа диапазонов антенны с сохранением основных показателей антенны. Также благодаря тому, что в процессе переключения режимов сохраняется лишь один резонанс антенны, то удается повысить помехозащищенность антенны, так как отсутствует прием на побочных каналах. Использованные для коммутаций метаматериала pin-диоды позволяют обеспечить быстрое переключение слоев, а также малое сопротивление во включенном режиме и этим обеспечить полученные высокие качественные характеристики, которые полостью соответствовали бы эквивалентным патч-антеннам с полной металлизацией
The article discusses the design of a planar patch antenna with an active metamaterial, which allows you to control the operating range of the antenna by connecting additional layers. Thanks to the design of such an antenna, it was possible to achieve that a rectangular patch antenna has four modes of operation, which provide four operating frequency bands of the antenna. At the same time, in all modes of operation of the antenna, stable characteristics are maintained, so the efficiency did not decrease below 72%, the directional coefficient of the antenna was not lower than 7.2 dB. Thanks to these characteristics, we can say that the use of active metamaterial in planar antennas can improve the characteristics of the antenna by increasing the number of antenna ranges while maintaining the main characteristics of the antenna. Also, due to the fact that in the process of switching modes, only one antenna resonance is preserved, it is possible to increase the noise immunity of the antenna since there is no reception on side channels. The pin diodes used for switching the metamaterial make it possible to ensure fast switching of layers, provide low resistance in the on mode, and thereby ensure the obtained high-quality characteristics that would correspond to equivalent full-metallization patch antennas Key words: patch antenna, metamaterial, multiband antenna
A Multivariate Regression Model to Explain the Altitudinal Distribution of Timberlines on the Eurasian Continent
Authors: Zhao Fang , Shakoor Abdul , Zaib Gul , Zhang Baiping , Lan Xincan , Tang Jiale 
Published: August 2022

Abstract
The altitude of alpine timberline elevation has been considered to correlate with certain climatic factors. Many related isotherms (e.g., warmest month 10 °C isotherm) have been proposed to explain the altitudinal distribution of alpine timberline at the global scale. However, any climatic index actually has a wide range at the alpine timberline position worldwide. The altitudinal position of the alpine timberline is related to far more than just one climatic factor. Therefore, we developed a multivariable model for timberline elevation variability by collecting data from 473 timberline sites on the Eurasian continent. We analyzed 12 climatic variables that potentially account for timberline variation. Principal component and regression analyses were used to mine four climatic variables. The mean temperature of the warmest month (MTWM), mean temperature of the coldest month (MTCM), climatic continentality (K), and annual precipitation (AP) explained 95% of the variability of timberline elevation. MTWM, MTCM, K, and AP contributed 18%, 41.28%, 34.9%, and 5.82%, respectively, to the altitudinal distribution of alpine timberline on the whole continent; 20%, 44%, 28.86%, and 7.14% in the eastern continent; and 17.71%, 39.79%, 40.21%, and 2.29% in the western continent. We showed that MTWM, MTCM, K, and AP are deterministic factors for the altitudinal distribution of alpine timberline in the Eurasian continent. MTCM and K contributed to explaining the altitudinal distribution of timberline both in the entire, eastern, and western parts of the Eurasian continent. Our research highlights the significance of MTCM for the altitudinal distribution of timberline.
Experimental Analysis on Properties of Engineered Cementitious Composite with Reactive Nano and Micro materials
Authors: chowdary Muppalla Venkata sai surya pratap , Asadi SS. 
Published: August 2022

Abstract
Engineered Cementitious Composite (ECC) is one of the high-performance-based structural components. The materials used in the preparation of this composite are responsible for its characteristics. To improve structural safety against acid rains, the impact of one of the significant acids (H2So4) on mechanical, durability, and microstructural characteristics of Nano MgO based ECC with the different fine aggregates namely, Silica sand, Indian Zone II River sand and Manufactured sand is analyzed. For this, three mixes (Mix-A with silica sand, Mix-B with river sand, Mix-C with 50% River sand+ 50% Manufactured sand) were considered and cast specimens. In the composition, a suitable content of Micro MgO and Micro Tio2 are available. These specimens are kept for 28days under water curing before placing in an acidic solution and normal (atmospheric at 25 to 400C) conditions. The performance of acid (5% concentration) exposed specimens is compared with the normal atmospheric conditions after 28days. Three layers are formed on the surface of each specimen at acid exposure and 2layers are formed under normal conditions. A small layer of Caco3 + Tio2 formed on top of the specimens, this was responsible for photocatalytic action to reduce Co2 into fuels. Below this layer, the brucite layer formed on the specimens that reduced further exposure to acid. Apart from this, the Gypsum layer formed in the acid-exposed specimens. All these layers are formed by the chemical reaction of Nano MgO, Micro MgO and Tio2 with other materials. These reactions were also responsible for the almost same strength and densification under both conditions. But Mix-C showed better performance than other mixes due to the presence of high content portlandite and micro MgO that are responsible for an increase in the thickness of layers.
Brain-correlates of processing local dependencies within a statistical learning paradigm
Authors: Tsogli Vera , Skouras Stavros , Koelsch Stefan 
Published: August 2022

Abstract
Statistical learning refers to the implicit mechanism of extracting regularities in our environment. Numerous studies have investigated the neural basis of statistical learning. However, how the brain responds to violations of auditory regularities based on prior (implicit) learning requires further investigation. Here, we used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of processing events that are irregular based on learned local dependencies. A stream of consecutive sound triplets was presented. Unbeknown to the subjects, triplets were either (a) standard, namely triplets ending with a high probability sound or, (b) statistical deviants, namely triplets ending with a low probability sound. Participants (n = 33) underwent a learning phase outside the scanner followed by an fMRI session. Processing of statistical deviants activated a set of regions encompassing the superior temporal gyrus bilaterally, the right deep frontal operculum including lateral orbitofrontal cortex, and the right premotor cortex. Our results demonstrate that the violation of local dependencies within a statistical learning paradigm does not only engage sensory processes, but is instead reminiscent of the activation pattern during the processing of local syntactic structures in music and language, reflecting the online adaptations required for predictive coding in the context of statistical learning
Philosophy of Dramatisation in the Context of Art Interaction in W. S. Maugham’s Novels
Authors: CHAIKOVSKA Olha , HUMENIUK Iryna , TROFYMENKO Anastasiia , KRUK Alina 
Published: August 2022

The present study deals with the novel dramatization in the context of the synthesis of the art in the literature of the 20th century. The changes in the literary text caused by introducing a new pictorial and expressive technique are given. The use of pictorial and theatrical ekphrasis in Maugham’s novels was analysed. W. S. Maugham’s novels are considered through the prism of his theatrical experience. The paper attempts to interpret his poetics of dramatization as a way out of the epic and the creation of a qualitatively new multi-plate and multifaceted phenomenon.
At the narrative level, there is an interruption in the integrity of the story. Vertical layers add a horizontal plan for the development of the plot, and the subjective structure has changed at the level of inclusion of several storytellers. The study revealed that the connotations to paintings and plays increase the effect of descriptiveness and enrich expressive, emotional, and sensual perception. The method of “points of view” is used to overcome the plane of description and move to the sphere of the display. The clash of diverse “points of view” and their filtering by the dominant “point of view” of the narrator increases the dramatization influence.
Recreational Sports Role in Strengthening Social Security From The Perspecive of The Employees at (Alasemeh Youth Directorate)
Authors: Akroush Sofia 
Published: August 2022

This study aims to identify the role of recreational sports in strengthening Social Security from the perspective of employees at (Alasemeh youth directorate), and to identify the differences among variables such as gender, experience and education. Data were collected randomly where the sample was 59 employees (51) Male (8).A questionnaire was designed and used as a tool to collect the data, in three fields, Psychology, social and sports field.The scientific coefficient in terms of validity and reliability were checked out. Data were analyzed by using the SPSS software. The findings showed that the role of recreational sports strengthens Social Security effectively. Also, the findings showed that there are significant differences in the total score according to the status of gender& certificate. In the contrary, there was no significant difference in the total score According to the level of experience. The researcher recommends that there is a need to promote recreational sports activities within the programs of youth centers and to increase allocations for the implementation of the sports programs by the Jordanian ministry of youth.
ПИТАННЯ ГАРМОНІЗАЦІЇ НАЦІОНАЛЬНОГО ЗАКОНОДАВСТВА З БІОЛОГІЧНОЇ БЕЗПЕКИ ТА БІОЛОГІЧНОГО ЗАХИСТУ З НОРМАМИ МІЖНАРОДНОГО ПРАВА
Authors: Горіславська Інна 
Published: August 2022

Серед завдань, які потребують вирішення для забезпечення біологічної безпеки, є узгодження національного законодавства з біологічної безпеки та біологічного захисту з нормами міжнародного права, міжнародними договорами і угодами, учасницею яких є Україна, забезпечення розвитку міжнародної співпраці у сфері забезпечення біологічної безпеки та біологічного захисту, підтримка міжнародних ініціатив у сфері біологічної безпеки, що корелюються із національними інтересами, розширення співпраці з міжнародними організаціями, а також у рамках двостороннього співробітництва з провідними державами світу для посилення спроможності України у сфері біологічної безпеки та біологічного захисту; організаційні дії по здійсненню контролю у сфері біологічної безпеки; підняття на вищий по ефективності рівень координації заходів із управління біологічними ризиками [1]. Актуальна перенаправленість пріоритетів правової охорони у бік людини мала суттєвий вплив і на регулювання відносин у сфері державного управління біологічною безпекою, а виклики у вигляді пандемій, біологічного тероризму, а на сьогодні – і військові дії в Україні, лише загострили їх [2].
USING NEURAL NETWORKS FOR MIMO DETECTION AND CHANNEL DECODING
Authors: Башкиров А.В. , Свиридова И.В. , Хорошайлова М.В. 
Published: August 2022

Предложен подход глубокого обучения для совместной задачи обнаружения MIMO и декодирования канала. Обычные приемники MIMO применяют подход на основе существующей модели для обнаружения MIMO и декодирования канала линейным или итеративным образом. Однако из-за сложной модели сигнала MIMO оптимальное решение проблемы совместного обнаружения MIMO и декодирования канала (то есть декодирование с максимальной вероятностью переданных кодовых слов из принятых сигналов MIMO) невозможно с вычислительной точки зрения. В качестве практической меры все современные приемники MIMO на основе стандартных моделей используют неоптимальные методы декодирования MIMO с доступной вычислительной сложностью. В этой работе применяются последние достижения в области глубокого обучения для проектирования приемников MIMO. В частности, используем глубокие нейронные сети (DNN) с контролируемым обучением для решения проблемы совместного обнаружения MIMO и декодирования каналов. DNN можно обучить для обеспечения гораздо лучшей производительности декодирования, чем это делают обычные приемники MIMO. Моделирование показывает, что реализация DNN, состоящая из семи скрытых слоев, может превзойти традиционные линейные или итерационные приемники на основе используемых моделей. Это улучшение производительности указывает на новое направление для будущей конструкции приемников MIMO
The article proposes a deep learning approach for the joint problem of MIMO detection and channel decoding. Conventional MIMO receivers use an existing model approach to detect MIMO and decode the channel in a linear or iterative manner. However, due to the complex model of the MIMO signal, an optimal solution to the problem of joint MIMO detection and channel decoding (i.e., maximum probability decoding of the transmitted codewords from the received MIMO signals) is computationally impossible. As a practical measure, all current standard model based MIMO receivers use sub-optimal MIMO decoding techniques with affordable computational complexity. This work applies the latest advances in deep learning to the design of MIMO receivers. In particular, we use deep neural networks (DNN) with supervised learning to solve the problem of joint MIMO detection and channel decoding. DNNs can be trained to provide much better decoding performance than conventional MIMO receivers. Simulations show that a DNN implementation consisting of seven hidden layers can outperform traditional linear or iterative receivers based on the models used. This performance improvement points to a new direction for future MIMO receiver design
Did the Āẕar Kaivānīs Know Zoroastrian Middle Persian Sources?
Authors: Rezania Kianoosh 
Published: August 2022

The Āẕar Kaivānīs, a syncretistic religious school in the sixteenth and seventeenth centuries, combined elements from Islam, Zoroastrianism, Buddhism and Ešrāqī philosophy. The Dasātīr, written by the first authority of the group, Āẕar Kaivān (943/1533–1028/1618), is a bilingual text. Its first language is an artificial encrypted language, represented as the language of heaven; the second is a specific form of New Persian, i.e., with few Arabic words. This article argues that Dasātīr’s author employed the Zoroastrian Zand as a model for the construction of his book. It moreover demonstrates the trace of some Middle Persian lexemes in it. Accordingly, it concludes that the Āẕar Kaivānīs were familiar with the Zoroastrian Middle Persian literature, if perhaps only superficially. The article also scrutinizes where and when contact occurred between Zoroastrianism and the Āẕar Kaivānī school. As a result, it discusses the Zoroastrian concept of secret language and the necessity of its translation and interpretation, which provided the Āẕar Kaivānīs with the possibility to include the notion of a secret book in their own system of thought.
ANALYSIS OF THE EFFECT OF COMPETENCY AND INDEPENDENCE ON THE QUALITY OF AUDITED FINANCIAL STATEMENTS AUDIT RISK AS MEDIATION DURING THE COVID 19 PANDEMIC (Empirical Study on KAP in Central Java)
Authors: Dewi Saptantinah Puji Astuti  , Aris Eddy Sarwono  
Published: August 2022

Cases of declining quality of audited financial reports in recent years have shown an increasing trend, supported by the existence of a pandemic condition with various obstacles faced by client companies, including financial difficulties, due to the impact of the pandemic, in such conditions the management is still required to account for the company's financial statements. The purpose of this study was to examine the effect of competence and independence on the quality of audited financial statements with audit risk as a mediating variable.
This study uses a survey method with primary data sources, obtained by distributing questionnaires to respondents. The population in this study was auditors at Public Accounting Firms throughout Central Java, the sampling technique was purposive sampling.
The results of the study using SEM PLS analysis showed that competence, independence and audit risk had a significant effect on the quality of audited financial statements, competence and independence had a significant effect on audit risk. While independence affects the quality of audited financial statements mediated by audit risk, while audit risk cannot mediate the effect of competence on the quality of audited financial statements. Suggestions for further research should be to expand the research sample and add variables that can affect the quality of audited financial statements such as the role of internal auditors.
Uterine septum misdiagnosed on hysterosalpingogram
Authors: Sheth S.S , Sonkawde R 
Published: July 2002

AbstractObjective: To evaluate the correctness of diagnosis of bicornuate uterus made on hysterosalpingogram. Method: Thirty‐six women diagnosed on hysterosalpingogram to have bicornuate uterus were subjected to laparoscopy and hysteroscopy. Result: Two out of 36 women had bicornuate uterus whereas the remaining 34 had intrauterine septum. Conclusion: Diagnosis of bicornuate uterus made on hysterosalpingogram by radiologists is often incorrect and needs to be revised.
Use of computerized image analysis to quantify staphylococcal adhesion to canine corneocytes: does breed and body site have any relevance to the pathogenesis of pyoderma?
Authors: Forsythe Peter J. , Hill Peter B. , Thoday Keith L. , Brown Jeremy 
Published: July 2002

AbstractAn optimized system of computerized image analysis was used to investigate variations in the adherence of Staphylococcus intermedius to canine corneocytes from four different breed groups and six different anatomical sites. S. intermedius showed significantly greater adherence to the head and neck compared with the dorsum, but adherence to the limb, axilla and groin did not differ from other sites. Furthermore, there was significantly greater adherence of S. intermedius to corneocytes from the dorsum, forelimb, axilla and groin of Boxers and Bull Terriers than Spaniels and Hounds. S. intermedius, and also Pseudomonas aeruginosa, exhibited abundant adherence, which was significantly greater than Staphylococcus aureus, Streptococcus canis, Klebsiella pneumoniae and Escherichia coli. In addition, S. intermedius adherence demonstrated a sigmoid dose–response curve with increasing bacterial concentration. These results suggest that S. intermedius adheres to canine corneocytes by a specific receptor–ligand interaction and adheres to the skin of some breeds more avidly than others. However, variations in adherence between body regions would not account for the predilection sites of canine bacterial pyoderma.