bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review/perspective on hysterical paralysis: A diagnosis of exclusion for spinal surgeons
Authors: Epstein Nancy E. 
Published: April 2022

Background:
Hysterical paralysis (HP) and/or conversion disorders (CD) are diagnoses of exclusion for spine surgeons. Before assigning this diagnosis to a patient, they must first undergo a full neurodiagnostic evaluation (i.e., X-rays, MR, CT/Myelo-CT) to rule out organic spinal pathology. Here, we reviewed select articles highlighting how to differentiate HP/CD patients from those with spinal disease.

Methods:
Several case studies and small series of patients with HP/CD were included in our analysis. Notably, prior to being assigned the diagnoses of HP/CD, patients had to first undergo X-ray, MR, CT, and/or Myelo-CT evaluations to rule out spinal disorders; typically, their neurodiagnostic studies were normal.

Results:
Patients with HP/CD often presented with varying clinical complaints of motor paralysis despite intact reflexes, normal sensory examinations, and lack of sphincter disturbance (i.e. intact rectal tone). Further, go and nogo functional MRI (fMRI) examinations demonstrated inconsistencies in areas of brain activation for patients with HP/CD complaints.

Conclusions:
HP/CD are diagnoses of exclusion, and patients should first undergo a full panel of neurodiagnostic studies to rule out organic spinal disease. While those with HP/CD should not have unnecessary operations, those with real “surgical pathology” should have appropriate spine surgery performed in a timely fashion.
On a new class of exact solutions of Quasi-Hydrodynamic system, generated by eigenfunctions of two-dimensional Laplace operator
Authors: Григорьева Вера Владимировна , Шеретов Юрий Владимирович 
Published: April 2022

Квазигидродинамическая система была предложена Шеретовым Ю.В. в 1993 году. Она отличается от системы Навье-Стокса в динамике вязкой несжимаемой жидкости дополнительными дивергентными членами. В работе методом Громеки-Бельтрами построено новое однопараметрическое семейство точных решений квазигидродинамической системы, которые удовлетворяют также системе Навье-Стокса. Это семейство порождается собственной функцией двумерного оператора Лапласа.
The quasi-hydrodynamic system was proposed by Sheretov Yu.V. in 1993. It differs from the Navier-Stokes system in dynamics of a viscous incompressible fluid by the additional divergent terms. In this paper, the Gromeki-Beltrami method is used to construct a new one-parameter family of exact solutions of a quasi-hydrodynamic system, which also satisfy to the Navier-Stokes system. This family is generated by the eigenfunction of two-dimensional Laplace operator.
The Nurse’s Role in Preventing Ventilator-Associated Pneumonia
Authors: KAŞ GÜNER Canan , KUTLUTÜRKAN Sevinç 
Published: April 2022

Ventilator-associated pneumonia(VAP) is an important condition constituting the half of the hospitaloriginated
pneumonia cases. The ventilator-associated pneumonia can result from microorganisms in
the patient’s own flora, visitors, hospital staff, other patients and environmental factors. Elimination
ofventilator-associated pneumonia, which causes high mortality rates, prolonged hospitalizations,
excessive use of antibiotics and consequently increased health expenditures in adult patients with
endotracheal intubation worldwide, is possible with multidisciplinary team work. In this adversaria, it is
thought that the methods applied to eliminate the risk of ventilator-associated pneumonia and nursing
practices will contribute to direct the care practices of the staff in charge and affect the patient care
results positively.
Üniversite Öğrencilerinin HPV, HPV Tarama Testi ve HPV Aşısına İlişkin Bilgi Düzeylerinin Değerlendirilmesi: Kesitsel Bir Çalışma
Authors: TURHAN ÇAKIR Anıl , PORSUK İpek , ÇALBIYIK Furkan , TANER Gülşah , NOĞAY Ayşe Ece , ASLAN Mehmet Emin , DEMİR Simge , CAN Cüneyt , ALTINER Eren , KILIÇ Şeyma Şura , YILMAZ Şevval , KARACA Zeliha , GÜNDOĞAN Yağmur , ŞEN Adem 
Published: April 2022

Amaç: Human Papilloma Virüs (HPV)’ün etken olduğu bilinen serviks kanseri, dünya çapında kadınlar
arasında en sık görülen üçüncü kanserdir ve yeni olguların çoğu az gelişmiş bölgelerden bildirilmektedir.
Çalışmamızda pre-klinik tıp fakültesi öğrencileri ile diğer fakültelerde öğrenim gören üniversite
öğrencilerinin HPV, HPV tarama testi ve HPV aşısına ilişkin bilgi düzeylerinin değerlendirilmesi
amaçlanmıştır. Bu yolla varsa sorunlar ortaya konularak, giderilmesine yönelik çalışmalara zemin
hazırlanacaktır.
Gereç ve Yöntemler: Tanımlayıcı ve kesitsel tipteki çalışmamız, 15 Şubat - 15 Mart 2021 tarihleri
arasında pre-klinik tıp fakültesi öğrencileri ile diğer fakültelerde öğrenim gören üniversite öğrencileri
arasında yapılmıştır. Kolayda örneklem yöntemiyle belirlenen 303 katılımcıya (n=303) sosyodemografik
sorular ve HPV Bilgi Ölçeği’nden oluşan iki aşamalı bir elektronik anket uygulanmıştır.
Bulgular: Katılımcıların %68,3’ü kadın (n=207), %31,7’si erkek (n=96), yaş ortalamalarının 20,94±1,69,
HPV Bilgi Ölçeği puanları ortalamasının 9,08±8,32 olduğu saptanmıştır. Katılımcıların %39,6’sının
(n=120) pre-klinik tıp fakültesi öğrencisi, %60,4’ünün (n=183) diğer fakültelerin öğrencileri olduğu
görülmüştür. HPV Bilgi Ölçeği puanları karşılaştırıldığında; pre-klinik tıp fakültesi öğrencilerinin diğer
öğrencilere göre toplam puanlarının anlamlı olarak yüksek olduğu görülmüştür (p0.05). Ankete katılanların anne ve babalarının eğitim düzeyi, cinsel yolla bulaşan
hastalıklar hakkında bilgi durumu, rahim ağzı kanserini duyma ve bilgisi olma, eğitim döneminde
ikamet edilen yer, hayatının en uzun bölümünü geçirdiği bölge ve fakültesinin bulunduğu bölgeler arasında
HPV Bilgi Ölçeği puanları açısından anlamlı fark olduğu bulunmuştur (p
Motricidade humana: o itinerário de um conceito
Authors: Sérgio Manuel 
Published: April 2022

Motricidade humana: o itinerário de um conceito
ResumoSão muitos os que se licenciaram em Educação Física e relativizam a fixidez do nome que pretende definir a sua profissão. Com efeito, nenhum deles se vê cartesianamente centrado na educação de físicos. A passagem do físico à motricidade que não confundo com movimento tão-só (ao invés de alguns estudiosos), surge como a mudança de lugar do corpo humano, num espaço e tempo determinados, com as características de um processo objetivo. Procuro fundamentar a motricidade humana na intencionalidade e no mundo da vida. Ao anunciar-se um novo paradigma (ação intencional e solidária de transcendência), a Ciência da Motricidade Humana procura servir também os anseios de todos os marginalizados pela sociedade injusta. Verdadeiramente, o Ser Humano é ser-ao-mundo-com-outrem. E tudo isto, em busca da transcendência, da superação, da plenitude, do ser-mais.Palavras-chave: Ciência da Motricidade Humana. Intencionalidade. Transcendência.
Human motricity: the itinerary of a concept
AbstractThere are many who graduated in Physical Education and relativize the fixity of the name that intends to define their profession. Indeed, none of them sees itself as being Cartesian focused on the education of physicists. The passage from the physical to the motricity, which I do not confuse with movement only (instead of some researchers), appears as the change of place of the human body, in a determined space and time, with the characteristics of an objective process. I try to ground human motricity in intentionality and in the world of life.
By announcing a new paradigm (the intentional and solidary action of transcendence), the Science of Human Motricity also seeks to serve the aspirations of all those marginalized by an unjust society. Truly, the Human Being is to-be-to-the-world-with-others. And all this, in search of transcendence, overcoming, fullness, from of to-be-most.Keywords: Human Motricity Science. Intentionality. Transcendence.
Motricidad humana: el itinerario de un concepto
ResumenSon muchos los que se gradúan en Educación Física y relativizan la fijeza del nombre que pretende definir su profesión. De hecho, ninguno de ellos se ve a sí mismo como cartesiano centrado en la formación de físicos. El paso de lo físico a la motricidad, que no confundo sólo con movimiento (a diferencia de algunos estudiosos), aparece como el cambio de lugar del cuerpo humano, en un espacio y tiempo determinados, con las características de un proceso objetivo. Intento fundamentar la motricidad humana en la intencionalidad y en el mundo de la vida. Al anunciar un nuevo paradigma (la acción intencional y solidaria de la trascendencia), la Ciencia de la Motricidad Humana también busca servir las aspiraciones de todos aquellos marginados por una sociedad injusta. Verdaderamente, el Ser Humano es ser-al-mundo-con-otren. Y todo ello, en busca de la trascendencia, la superación, la plenitud, del ser-más.Palabras clave: Ciencia de la Motricidad Humana. Intencionalidad. Trascendencia.
OSMANLI DEVLETİ’NDE TAŞRADA MUHTARLIK TEŞKİLATININ KURULUŞU: BOLU ÖRNEĞİ
Authors: SÜME Mehmet 
Published: April 2022

II. Mahmut (1808-1839) iktisadi, askeri, idari, hukuki, eğitim ve sosyal alanlarda bir dizi yenilikler yapmıştır. Bu yeniliklerin birçoğunun en karakteristik özelliği alanlarında ilk olmalarıdır. Bu ilklerden biri de Osmanlı ülkesinde muhtarlık teşkilatının kurulmasıdır. Osmanlı Devleti’nde XIX. yüzyılın ilk yarısına kadar köy mahalle idaresinden imamlar sorumluydu. Muhtarlık teşkilatı ilk kez 1829’da İstanbul’da kuruldu. Bu uygulama taşrada ise ilk kez Kastamonu’da gerçekleştirilmiştir. Kastamonu sancağı mütesellimi Dede Mustafa Ağa İstanbul’daki muhtarlık uygulamasını örnek alarak 1833 yılında taşradaki ilk muhtarlık uygulamasını başlatmıştır. Dede Mustafa Ağa Kastamonu’da yaptığı çalışmaları ve elde ettiği sonuçları bir rapor haline getirerek İstanbul’a sunmuştur. Dönemin padişahı II. Mahmud bu uygulamadan memnun kalmış ülke genelinde muhtarlık teşkilatın ihdas edilmesini istemiştir.
Bolu bu dönemde Kastamonu Eyaletine bağlı bir sancak statüsündeydi. Dolayısıyla Bolu taşrada Kastamonu ile birlikte muhtarlık teşkilatının ilk kurulduğu beldelerden biridir. Bolu sancağında seçilen muhtarların isimleri 19 Haziran 1834 tarihi itibarıyla İstanbul’a bildirilmiştir. Bu çalışmada Bolu’da muhtarlık teşkilatının kuruluşu anlatılarak teşkilatın taşrada kuruluşuna ilişkin bilgiler verilmeye çalışılacaktır. Ayrıca muhtarlık teşkilatının taşrada kuruluşuna ilişkin Anadolu ve Rumeli’deki uygulamalarından, örnekler verilerek konuya ilişkin farklı yaklaşımlar bir karara bağlanmaya çalışılmıştır. Benzer bir husus gayrimüslim mahallelerindeki kocabaşı veya kethüda seçimi için de geçerlidir.
Design, Development and Evaluation of Aceclofenac Matrix Tablet Using Eudragit and Carbopol as Matrix Forming Agents
Authors: Chatterjee Arindam , Patel Alok M , Gupta Rakesh Kumar , Mishra Anuj 
Published: April 2022

Aceclofenac is a non-steroidal anti-inflammatory, analgesic and antipyretic agent. It has short biological half-life (4 hours). The present study aims to formulate sustained release Matrix tablet of Aceclofenac for improved patient compliance, better therapeutic efficacy, less side effects and reduced dosage regimen with less toxicity. Total six formulations (F1-F6) were prepared with varying ratios of Eudragit RS100 and Carbopol 934P as matrix forming agents and evaluated for various pre-compression and post compression parameters. Formulation (F3) containing 1:1 ratio of Eudragit RS100 and Carbopol 934P showed promising results in dissolution studies when compared to the rest of the formulations.
Keywords: Aceclofenac, Matrix Tablets, Eudragit, Carbopol, Sustained Release.
Pengaruh Postur Tubuh Saat Belajar Online Terhadap Keluhan Muskuloskeletal
Authors: Mauluddin Yusuf , Maessa Chika Ajeng 
Published: April 2022

Penelitian ini bertujuan untuk mengidentifikasi postur tubuh saat belajar online yang berpengaruh terhadap keluhan muskuloskeletal dan merekomendasikan perbaikan untuk mengurangi keluhan tersebut. Identifikasi permasalahan dilakukan atas dasar postur tubuh yang sering dilakukan dan keluhan yang dialami mahasiswa itu sendiri. Metode yang digunakan dalam mengidentifikasi masalah ini yaitu metode kuesioner Nordic Body Map, dan metode REBA (Rapid Entire Body Assessment). Metode kuesioner Nordic Body Map bertujuan untuk mengetahui keluhan muskuloskeletal yang dialami, sedangkan metode REBA bertujuan untuk mengetahui tingkat bahaya dari postur tubuh yang sering dilakukan. Rekomendasi perbaikan dilakukan dengan metode pengukuran antropometri bertujuan untuk merencanakan alat bantu sebagai alternatif untuk mengurangi keluhan-keluhan tersebut. Hasil dari penelitian ini diperoleh sebanyak 34% postur tubuhnya yaitu lesehan dengan posisi punggung tegak dan tidak ada sandaran, 21% duduk dikursi dengan kaki sila dan leher yang menekuk, 10% dan dari 80 mahasiswa mengalami sakit pada bagian bawah leher, atas leher, punggung, pinggang dan bagian pantat. Hasil dari perbaikan dalam pembuatan alat bantu yaitu meja yang dapat diatur ketinggiannya dari posisi duduk lesehan, duduk dikursi dan saat berdiri. Meja tersebut harus memiliki dua dudukan, yang pertama untuk sandaran tangan dan yang kedua untuk penyimpanan laptop agar dapat mengurangi keluhan-keluhan muskuloskeletal.
USING DIGITAL LEARNING TECHNOLOGY IN THE PROCESS OF LINGUOMETHODOLOGICAL TRAINING OF FUTURE FOREIGN LANGUAGE TEACHERS
Authors: Khomyshak Oksana B. 
Published: April 2022

The article focuses on the use of Digital Learning Technology for the development of foreign language communicative and methodological competences of future foreign language teachers in the process of linguomethodological training. The author provides definitions for “methodological competence of future foreign language teachers” and “Digital Learning Technology”. The didactic typology of digital learning tools to be used at different stages of developing and testing of all aspects of foreign language communicative competence and speech activities has been suggested by the author. The article deals with the use of the blended method via the MyEnglishLab e-platform, which ensures online interaction, individualised, autonomous and asynchronous way of developing students’ English communicative competence. The author used her English teaching experience to describe, define and provide examples of a new variety of project-based learning: digitised project. The innovativeness of the presented methods involving the use of digital learning tools (e.g. software tools, e-platforms, multimedia tools, e-resources) has resulted in interactive, productive and creative English learning. A wide range of new teaching methods (blended learning, flipped classroom, edutainment, professionally oriented project-based learning activities, screencast technology, webquest technology) for the development of methodological competence of future foreign language teachers with Digital Learning Technology use has been demonstrated. Special focus has been made on blog technology (teacher’s and student’s blogging), which gives the possibility to produce and showcase professional information and activity using multimedia tools (dynamic and static images, video, etc.). Based on the scientific observation, questionnaire and survey, the frequency of digital learning tools use, their diversity, advantages and disadvantages in the process of linguomethodological training of students at Drohobych Ivan Franko State Pedagogical University have been determined. Thus, the feasibility of the suggested methodology of Digital Learning Technology use in linguomethodological training of future foreign language teachers has been proved experimentally and using methods of mathematical statistics.
Non-Apoptotic Programmed Cell Death-Related Gene Signature Correlates With Stemness and Immune Status and Predicts the Responsiveness of Transarterial Chemoembolization in Hepatocellular Carcinoma
Authors: Zhang Guixiong , Fan Wenzhe , Wang Hongyu , Wen Jie , Tan Jizhou , Xue Miao , Li Jiaping 
Published: April 2022

Background: Non-apoptotic programmed cell death, including autophagy, ferroptosis, and pyroptosis, newly discovered in recent years, plays an important role in hepatocellular carcinoma (HCC). So, this study attempted to explore the relationship between non-apoptotic programmed cell death-related genes and the molecular characteristics, tumor microenvironment, and prognosis in HCC patients.Methods: The transcriptomic and clinical data of HCC samples were downloaded from various public datasets, followed by acquiring non-apoptotic programmed cell death-related genes from the database. A gene signature model was then constructed using univariate and multivariate Cox regression analyses and validated in other cohorts as well as our institution sequencing data. Kaplan–Meier survival curves and time-dependent receiver operating characteristic curves were generated to evaluate the model’s predictive capability. Furthermore, the relationships among the gene signature, TP53 mutation, stemness, immune status, and responsiveness of transarterial chemoembolization (TACE) were analyzed.Results: The gene signature model was constructed based on five autophagy-, three ferroptosis-, and two pyroptosis-related differentially expressed genes. The model accurately predicted that patients classified as low risk would have better overall survival than high-risk patients, which was robustly consistent with data from other cohorts as well as our institution sequencing data. The comprehensive results indicated that a high-risk index was correlated with a high TP53 mutation rate, high cancer cell stemness, high infiltration of immunosuppressive cells and low immunophenoscore, and low TACE responsiveness of HCC patients.Conclusion: Collectively, the established non-apoptotic programmed cell death-related gene signature was shown to accurately predict prognosis, associated with the TP53 mutation and liver cancer cell stemness, reflect the tumor immune microenvironment, and predict TACE responsiveness in HCC patients.
A Portable Fluorescent Hydrogel-Based Device for On-Site Quantitation of Organophosphorus Pesticides as Low as the Sub-ppb Level
Authors: Wang Tuhui , Zhang Lening , Xin Hua 
Published: April 2022

Portable devices possess powerful application prospects in on-site sensing without the limitation of bulky instruments. Given the relevance of pesticides to food safety, we herein fabricated a robust gold nanocluster (AuNC)-based hydrogel test kit for precisely quantified chlorpyrifos by using a three-dimensional (3D) printed subsidiary device. In this work, the fluorescence of AuNC-based hydrogel could be efficiently quenched by cobalt oxyhydroxide nanoflakes (CoOOH NFs) through the Förster resonance energy transfer effect. Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel. By using a homemade subsidiary device and smartphone, the fluorescence color was transformed into digital information, achieving the on-site quantitative detection of chlorpyrifos with the limit of detection of 0.59 ng ml−1. Owing to specific AuNC signatures and hydrogel encapsulation, the proposed fluorescence hydrogel test kit displayed high sensitivity, good selectivity, and anti-interference capability in a real sample analysis, providing great potential in on-site applications.
Pyrene Functionalized Highly Reduced Graphene Oxide-palladium Nanocomposite: A Novel Catalyst for the Mizoroki-Heck Reaction in Water
Authors: Khan Mujeeb , Ashraf Muhammad , Shaik Mohammed Rafi , Adil Syed Farooq , Islam Mohammad Shahidul , Kuniyil Mufsir , Khan Merajuddin , Hatshan Mohammad Rafe , Alshammari Riyadh H. , Siddiqui Mohammed Rafiq H. , Tahir Muhammad Nawaz 
Published: April 2022

The formation of a C-C bond through Mizoroki-Heck cross-coupling reactions in water with efficient heterogeneous catalysts is a challenging task. In this current study, a highly reduced graphene oxide (HRG) immobilized palladium (Pd) nanoparticle based catalyst (HRG-Py-Pd) is used to catalyze Mizoroki-Heck cross-coupling reactions in water. During the preparation of the catalyst, amino pyrene is used as a smart functionalizing ligand, which offered chemically specific binding sites for the effective and homogeneous nucleation of Pd NPs on the surface of HRG, which significantly enhanced the physical stability and dispersibility of the resulting catalyst in an aqueous medium. Microscopic analysis of the catalyst revealed a uniform distribution of ultrafine Pd NPs on a solid support. The catalytic properties of HRG-Py-Pd are tested towards the Mizoroki-Heck cross-coupling reactions of various aryl halides with acrylic acid in an aqueous medium. Furthermore, the catalytic efficacy of HRG-Py-Pd is also compared with its non-functionalized counterparts such as HRG-Pd and pristine Pd NPs (Pd-NPs). Using the HRG-Py-Pd nanocatalyst, the highest conversion of 99% is achieved in the coupling reaction of 4-bromoanisol and acrylic acid in an aqueous solution in a relatively short period of time (3 h), with less quantity of catalyst (3 mg). Comparatively, pristine Pd NPs delivered lower conversion (∼92%) for the same reaction required a long reaction time and a large amount of catalyst (5.3 mg). Indeed, the conversion of the reaction further decreased to just 40% when 3 mg of Pd-NPs was used which was sufficient to produce 99% conversion in the case of HRG-Py-Pd. On the other hand, HRG-Pd did not deliver any conversion and was ineffective even after using a high amount of catalyst and a longer reaction time. The inability of the HRG-Pd to promote coupling reactions can be attributed to the agglomeration of Pd NPs which reduced the dispersion quality of the catalyst in water. Therefore, the high aqueous stability of HRG-Py-Pd due to smart functionalization can be utilized to perform other organic transformations in water which was otherwise not possible.
Novel Triterpenoid Alkaloids With Their Potential Cytotoxic Activity From the Roots of Siraitia grosvenorii
Authors: Wang Huijuan , Ma Guoxu , Wang Huaxiang , Li Lingyu , Dong Aijun , Liu Huiping , Huo Xiaoshuang , Si Jianyong , Wang Junchi 
Published: April 2022

Four novel triterpenoid alkaloids, siragrosvenins A–D (1–4), and two new cucurbitane-type triterpenoids, siragrosvenins E–F (5, 6), together with eight known analogs (7−14), were isolated from the roots of Siraitia grosvenorii. Compounds 1−4 possessed a rare cucurbitane-type triterpenoid scaffold, featuring an extra pyrazine unit via the Strecker reaction in the cucurbitane framework. Compound 5 displayed a 6/6/6/5/6/5-fused polycyclic ring system, with an uncommon fused furan and pyran ring in the side chain. All the structures were characterized by extensive spectroscopic analysis, including HRESIMS, NMR, and X-ray crystallographic data. It is worth noting that the DP4+ analysis method was applied for the first time to determine the absolute configurations of the trihydroxybutyl moiety in the side chain of compounds 1–4. In vitro cytotoxicity screening found that compounds 4, 8, 9, 13, and 14 exhibited remarkable cytotoxic activities against three cell lines with IC50 values ranging from 1.44 to 9.99 μM. Siragrosvenin D shows remarkable cytotoxic activity on MCF-7 cells. As a result, it inhibited the proliferation of MCF-7 cells and reduced their viability via the induction of G2/M phase arrest and significantly induced apoptosis in MCF-7 cells.