bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel grading system for ischemia‒reperfusion injury manifestations in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention
Authors: Wang Xiaotong , Li Binbin , Hu Yue , Xiao Shengjue , Guo Minjia , Xu Tao , Wu Huimin , Huan Chunyan , Yin Jie , Zhu Hong , Pan Defeng 
Published: November 2022

AbstractTo establish a simple myocardial ischemia‒reperfusion injury (MIRI) manifestation grading system based on clinical manifestations and coronary angiography during primary percutaneous coronary intervention (PPCI). All STEMI patients treated with PPCI from June 2018 to November 2019 were included. According to the MIRI manifestation grade, patients were divided into four grades (I–IV). Laboratory and clinical indicators of the patients and the occurrence of major adverse cardiac events (MACEs) within one year of follow-up were analyzed. A total of 300 patients were included. The higher the MIRI manifestation grade, the lower was the high-density lipoprotein cholesterol (HDL-C); the higher were the C-reactive protein (CRP), lipoprotein(a) [LP(a)], and peak levels of high-sensitivity troponin T (hs-cTnT), creatine kinase (CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP); and the higher were the proportions of right coronary artery (RCA) and multivessel lesions (P < 0.05). The left ventricular end-diastolic dimension (LVEDD) and E/e′ values of patients with higher grades were significantly increased, while the LVEF, left ventricular short-axis functional shortening (LVFS) and E/A values were significantly decreased (P < 0.05). The one-year cumulative incidence of major adverse cardiac events (MACEs) in patients with grade I–IV disease was 7.7% vs. 26.9% vs. 48.4% vs. 93.3%, respectively,P < 0.05. The higher the MIRI manifestation grade, the more obvious is the impact on diastolic and systolic function and the higher is the cumulative incidence of MACEs within one year, especially in patients with multivessel disease, low HDL-C, high CRP, high LP(a) levels, and the RCA as the infarction-related artery.
Novel deep learning hybrid models (CNN-GRU and DLDL-RF) for the susceptibility classification of dust sources in the Middle East: a global source
Authors: Gholami Hamid , Mohammadifar Aliakbar 
Published: November 2022

AbstractDust storms have many negative consequences, and affect all kinds of ecosystems, as well as climate and weather conditions. Therefore, classification of dust storm sources into different susceptibility categories can help us mitigate its negative effects. This study aimed to classify the susceptibility of dust sources in the Middle East (ME) by developing two novel deep learning (DL) hybrid models based on the convolutional neural network–gated recurrent unit (CNN-GRU) model, and the dense layer deep learning–random forest (DLDL-RF) model. The Dragonfly algorithm (DA) was used to identify the critical features controlling dust sources. Game theory was used for the interpretability of the DL model’s output. Predictive DL models were constructed by dividing datasets randomly into train (70%) and test (30%) groups, six statistical indicators being then applied to assess the DL hybrid model performance for both datasets (train and test). Among 13 potential features (or variables) controlling dust sources, seven variables were selected as important and six as non-important by DA, respectively. Based on the DLDL-RF hybrid model – a model with higher accuracy in comparison with CNN-GRU–23.1, 22.8, and 22.2% of the study area were classified as being of very low, low and moderate susceptibility, whereas 20.2 and 11.7% of the area were classified as representing high and very high susceptibility classes, respectively. Among seven important features selected by DA, clay content, silt content, and precipitation were identified as the three most important by game theory through permutation values. Overall, DL hybrid models were found to be efficient methods for prediction purposes on large spatial scales with no or incomplete datasets from ground-based measurements.
Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system
Authors: Wan Chun , Stowell Michael H. B. , Shen Jingshi 
Published: November 2022

AbstractA fundamentally novel function proposed for extracellular vesicles (EVs) is to transfer bioactive molecules in intercellular signaling. In this minireview, we discuss recent progress on EV-mediated cargo transfer in the central nervous system (CNS) and major gaps in previous studies. We also suggest a set of experiments necessary for bridging the gaps and establishing the physiological roles of EV-mediated cargo transfer.
Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells
Authors: Quicke Peter , Sun Yilin , Arias-Garcia Mar , Beykou Melina , Acker Corey D. , Djamgoz Mustafa B. A. , Bakal Chris , Foust Amanda J. 
Published: November 2022

AbstractCancer cells feature a resting membrane potential (Vm) that is depolarized compared to normal cells, and express active ionic conductances, which factor directly in their pathophysiological behavior. Despite similarities to ‘excitable’ tissues, relatively little is known about cancer cell Vm dynamics. Here high-throughput, cellular-resolution Vm imaging reveals that Vm fluctuates dynamically in several breast cancer cell lines compared to non-cancerous MCF-10A cells. We characterize Vm fluctuations of hundreds of human triple-negative breast cancer MDA-MB-231 cells. By quantifying their Dynamic Electrical Signatures (DESs) through an unsupervised machine-learning protocol, we identify four classes ranging from "noisy” to “blinking/waving“. The Vm of MDA-MB-231 cells exhibits spontaneous, transient hyperpolarizations inhibited by the voltage-gated sodium channel blocker tetrodotoxin, and by calcium-activated potassium channel inhibitors apamin and iberiotoxin. The Vm of MCF-10A cells is comparatively static, but fluctuations increase following treatment with transforming growth factor-β1, a canonical inducer of the epithelial-to-mesenchymal transition. These data suggest that the ability to generate Vm fluctuations may be a property of hybrid epithelial-mesenchymal cells or those originated from luminal progenitors.
A critical bioenergetic switch is regulated by IGF2 during murine cartilage development
Authors: Hollander Judith M. , Li Lingyun , Rawal Miraj , Wang Si Kun , Shu Yue , Zhang Ming , Nielsen Heber C. , Rosen Clifford J. , Zeng Li 
Published: November 2022

AbstractLong bone growth requires the precise control of chondrocyte maturation from proliferation to hypertrophy during endochondral ossification, but the bioenergetic program that ensures normal cartilage development is still largely elusive. We show that chondrocytes have unique glucose metabolism signatures in these stages, and they undergo bioenergetic reprogramming from glycolysis to oxidative phosphorylation during maturation, accompanied by an upregulation of the pentose phosphate pathway. Inhibition of either oxidative phosphorylation or the pentose phosphate pathway in murine chondrocytes and bone organ cultures impaired hypertrophic differentiation, suggesting that the appropriate balance of these pathways is required for cartilage development. Insulin-like growth factor 2 (IGF2) deficiency resulted in a profound increase in oxidative phosphorylation in hypertrophic chondrocytes, suggesting that IGF2 is required to prevent overactive glucose metabolism and maintain a proper balance of metabolic pathways. Our results thus provide critical evidence of preference for a bioenergetic pathway in different stages of chondrocytes and highlight its importance as a fundamental mechanism in skeletal development.
Superior colliculus saccade motor bursts do not dictate movement kinematics
Authors: Zhang Tong , Malevich Tatiana , Baumann Matthias P. , Hafed Ziad M. 
Published: November 2022

AbstractThe primate superior colliculus (SC) contains a topographic map of space, such that the anatomical location of active neurons defines a desired eye movement vector. Complementing such a spatial code, SC neurons also exhibit saccade-related bursts that are tightly synchronized with movement onset. Current models suggest that such bursts constitute a rate code dictating movement kinematics. Here, using two complementary approaches, we demonstrate a dissociation between the SC rate code and saccade kinematics. First, we show that SC burst strength systematically varies depending on whether saccades of the same amplitude are directed towards the upper or lower visual fields, but the movements themselves have similar kinematics. Second, we show that for the same saccade vector, when saccades are significantly slowed down by the absence of a visible saccade target, SC saccade-related burst strengths can be elevated rather than diminished. Thus, SC saccade-related motor bursts do not necessarily dictate movement kinematics.
Collagen piezoelectricity in osteogenesis imperfecta and its role in intrafibrillar mineralization
Authors: Kwon Jinha , Cho Hanna 
Published: November 2022

AbstractIntrafibrillar mineralization plays a critical role in attaining desired mechanical properties of bone. It is well known that amorphous calcium phosphate (ACP) infiltrates into the collagen through the gap regions, but its underlying driving force is not understood. Based on the authors’ previous observations that a collagen fibril has higher piezoelectricity at gap regions, it was hypothesized that the piezoelectric heterogeneity of collagen helps ACP infiltration through the gap. To further examine this hypothesis, the collagen piezoelectricity of osteogenesis imperfecta (OI), known as brittle bone disease, is characterized by employing Piezoresponse Force Microscopy (PFM). The OI collagen reveals similar piezoelectricity between gap and overlap regions, implying that losing piezoelectric heterogeneity in OI collagen results in abnormal intrafibrillar mineralization and, accordingly, losing the benefit of mechanical heterogeneity from the fibrillar level. This finding suggests a perspective to explain the ACP infiltration, highlighting the physiological role of collagen piezoelectricity in intrafibrillar mineralization.
Development and Validation of Sentences in Tamil for Psychoacoustic Evaluation of Voice Using the Consensus Auditory-Perceptual Evaluation of Voice
Authors: Venkatraman Yamini , Mahalingam Shenbagavalli , Boominathan Prakash 
Published: November 2022

Purpose:
The Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) is a standardized instrument used in voice assessment to assess voice quality. It has been translated and culturally adapted in several languages. This study aimed at developing and validating a Tamil version of CAPE-V through auditory perceptual evaluation of remotely recorded voice samples.

Method:
The Tamil version was adapted with permission from the American Speech-Language-Hearing Association to match the rationale in English CAPE-V. The sentences were constructed by the first author and validated for content by two panels of experts. Forty-five participants (15 cases and 30 controls) were included in the study. Data recording was conducted online (Zoom Video Communications, Inc., app) for all samples. Three raters participated in the auditory evaluation and scored all samples using Grade, Roughness, Breathiness, Asthenia, and Strain (GRBAS) scale followed by CAPE-V with a week gap in between. Twenty percent of samples were repeated to assess intrarater reliability. The intrarater and interrater reliability measures for Tamil CAPE-V were established using intraclass coefficients (ICCs). To ensure construct validity, group differences were determined between the cases and controls. The concurrent validity was established by correlating Tamil CAPE-V with the GRBAS scale.

Results:

The intrarater reliability for Tamil CAPE-V ranged from moderate to excellent (ICC: .610–.998). The Tamil CAPE-V obtained moderate to good interrater reliability for all parameters (ICC: .525–.790) except pitch (ICC: .405). The differences between the cases and controls were statistically significant (
p
< .01). The correlation between CAPE-V and GRBAS was strong for overall severity, breathiness, and strain (
r
s
= .725–.861) and moderate for roughness (
r
s
= .678).

Conclusion:
The Tamil CAPE-V is a reliable and valid tool for auditory perceptual evaluation in Tamil-speaking populations.

Supplemental Material:

https://doi.org/10.23641/asha.21513885
Palate Re-Repair for Velopharyngeal Insufficiency Treatment: A Long-Term Auditory-Perceptual Assessment of Speech
Authors: Araújo Bruna Mara Adorno Marmontel , da Silva Andressa Sharllene Carneiro , Bertier Carlos Eduardo , de Sousa Brosco Telma Vidotto , Yamashita Renata Paciello , Sampaio-Teixeira Ana Claudia Martins , Trindade Inge Elly Kiemle 
Published: November 2022

Purpose:
The purpose of this study was to assess the effectiveness of the palate re-repair by the auditory-perceptual assessment of speech.

Method:
Nonsyndromic individuals with operated cleft palate ± lip and velopharyngeal insufficiency (VPI), aged 6–22 years (10 men and 10 women), were referred to secondary palate surgery by the Sommerlad technique. Speech characteristics related to velopharyngeal function (VPF) were analyzed by auditory-perceptual assessment using digital audio recording 5 days before and 13 months after the palate re-repair, on average. Hypernasality, global impression of VPF, and active speech symptoms were scored and blindly rated by three experienced speech-language pathologists before and after surgery. The effect of age and the type of cleft on the outcomes was also analyzed.

Results:
Surgical success, interpreted as the elimination or reduction of hypernasality, was observed in 13 of the 20 patients analyzed (65%). Adequate nasality was observed in 55% of the patients, and the degree of hypernasality decreased from moderate to mild in 10% of the patients. Postoperative normal nasality was only seen among the children (73%). There was a tendency for better outcomes in patients with unilateral cleft lip and palate.

Conclusions:
The auditory-perceptual assessment of speech showed that re-repairs were effective in eliminating hypernasality and normalizing VPF in the majority of children analyzed, but not among the adults. In view of these results, the Sommerlad surgery should be prioritized in children as a secondary intervention in order to eliminate VPI.
Functionalised B‐Cu@F‐Ag@Au trimetallic nanomaterials with long term stability for rapid and highly sensitive in situ SERS detection of furfural in transformer oil
Authors: Lei Yu , Wang Changding , Kong Weiping , Wang Mingliang , Zhang Xinyuan , Nima Abdolmaleki , Wang Caisheng , Chen Weigen , Wan Fu 
Published: November 2022

AbstractThe surface‐enhanced Raman scattering (SERS) substrates enable a highly sensitive detection of furfural in the transformer oil. However, detection substrates with long‐term stability are still extremely challenging. In this work, we anchored the thiol‐containing coupling agents 2, 5‐dimercapto‐1, 3, 4‐thiadiazole (DMTD) and 1, 4‐benzenedithiol (BDT) on the surface of bubble copper (B‐Cu) and flower‐like silver nanoparticles (F‐Ag), respectively. The three‐dimensional SERS detection substrates with long‐term stability by using a combination of chemical reduction and self‐assembly methods were constructed. The substrate has a minimum detection limit of 10−9 M for rhodamine B in oil with an enhancement factor of up to 2.23 × 107. Importantly, the three‐crystal B‐Cu@F‐Ag1@Au5 substrate was used for the detection of furfural in the transformer oil with a detection limit of 2 mg/L and a relative standard deviation value of 2.46%. After 60 days of a simulated operation, the detection signal of furfural in the transformer oil samples at 75°C and still reached the initial value of 77.53%, indicating that the substrate has a good long‐term stability. This triple frame structured SERS detection platform shows great potential in tracking furfural in the aging transformer oil mixing systems.
A novel broadband polarisation conversion reflective metasurface
Authors: Qu Xun , Ding Jun , Yuan Yi , Guo Chenjiang 
Published: November 2022

AbstractA metasurface‐based broadband reflective polarisation converter with dual L‐shaped patches and dual trapezoidal patches for linear‐to‐linear polarisation conversion and linear‐to‐circular polarisation conversion is proposed in this study. The simulated and measured results demonstrate that the polarisation rotation can be effectively implemented in the frequency bands 9.24–12.25 GHz and 21.23–23.01 GHz, with the fractional bandwidth of the former being 28.01%. In addition, linear‐to‐circular polarisation conversion is performed with fractional bandwidths of 42.86% and 14.49% at 13.09–20.23 GHz and 23.62–27.31 GHz respectively. In the primary bands of linear‐to‐linear polarisation conversion and linear‐to‐circular polarisation conversion, the converter can operate within an incident angle range of 55° for polarised wave. This design may have potential uses in polarisation control devices used in the field of communications in X‐, Ku‐ and K‐bands.
Damping torque analysis for open‐loop modal resonance as a cause of torsional sub‐synchronous oscillations excited by grid‐connected wind farms
Authors: Bu Siqi , Zhang Jiangfeng , Chung C. Y. 
Published: November 2022

AbstractIncidents of sub‐synchronous oscillations (SSOs) reported in the Hami power network of western China indicate that the torsional dynamics of a synchronous generator (SG) can be excited by a grid‐connected wind farm and trigger torsional SSOs. The concept of open‐loop modal resonance (OLMR) reveals the excitation mechanism from the standpoint of system modal condition. This paper proposes a novel damping torque analysis (DTA) for detecting and assessing the risk of OLMR exciting torsional SSOs in a complex power system with multiple grid‐connected wind farms. The proposed analysis is modal‐computational free and can also accurately identify the grid‐connected wind farm responsible for the excitation of the torsional SSOs. Moreover, the proposed DTA provides a physical insight into the OLMR to facilitate an understanding of the essential reasons that the OLMR may excite torsional SSOs. The effectiveness of the proposed DTA is demonstrated and evaluated in an example power system with multiple grid‐connected wind farms.
A robust estimation of the twist distribution in magnetic clouds
Authors: Lanabere V. , Démoulin P. , Dasso S. 
Published: November 2022

Context. Magnetic clouds (MCs) are observed in situ by spacecraft. The rotation of their magnetic field is typically interpreted as the crossing of a twisted magnetic flux tube, or flux rope, which was launched from the solar corona.
Aims. The detailed magnetic measurements across MCs permit us to infer the flux rope characteristics. Still, the precise spatial distribution of the magnetic twist is challenging, and thus is debated.
Methods. In order to improve the robustness of the results, we performed a superposed epoch analysis (SEA) of a set of well observed MCs at 1 au. While previous work was done using the MC central time, we here used the result of a fitted flux rope model to select the time of the closest approach to the flux rope axis. This implies a precise separation of the in- and outbound regions to coherently phase the observed signals. We also searched for and minimised the possible biases such as magnetic asymmetry and a finite impact parameter.
Results. We applied the SEA to derive the median profiles both for the flux rope remaining when crossed by the spacecraft and to recover the one present before erosion. In particular, the median azimuthal B component is nearly a linear function of the radius. More generally, the results confirm our previous results realised without such a deep analysis. The twist profile is nearly uniform in the flux rope core, with a steep increase at the border of the flux rope and with similar profiles in the in- and outbound regions. The main difference with our previous study is a larger twist by ∼20%.
The Nobel Prize time gap
Authors: Mitsis Pandelis 
Published: November 2022

AbstractThe time lag between the publication of a major scientific discovery and the conferment of a Nobel Prize has been rapidly increasing for the natural science disciplines (chemistry, medicine-physiology, and physics), but has not yet matched the corresponding “waiting period” for the Nobel Prize in Economics. The aim of the present study is to empirically examine the time gap between pioneering work and Nobel recognition and discuss possible explanations for its variation across time and disciplines. The analysis provides evidence to support the argument that attributes such as bestowments of accolades widely regarded as Nobel Prize precursors, citation indices, and sharing of the award between multiple recipients, may explain this variation, but only to some extent. In the discussion that follows, the notably longer waiting period in economics is attributed to factors such as the laureates’ age, the impact of which the current study cannot empirically examine. Since the Nobel Prize cannot be awarded posthumously, the Nobel Committee members may tend to grand the award to older economists before they pass away and become ineligible.
Characterization of commercial thermoelectric modules for precision heat flux measurement
Authors: Crossley Jacob , Elahi A. N. M. Taufiq , Ghashami Mohammad , Park Keunhan 
Published: November 2022

In this article, we present a cost-effective approach to the precision measurement of heat flux using commercial thermoelectric modules (TEMs). Two different methods of measuring heat flux with TEMs are investigated, namely, passive mode based on the Seebeck effect and active mode based on the Peltier effect. For both modes, a TEM as a heat flux meter is calibrated to show a linear relation between the voltage across the TEM and the heat flux from 0 to ∼450 W m−2. While both modes exhibit sufficiently high sensitivities suitable for low heat flux measurement, active mode is shown to be ∼7 times more sensitive than passive mode. From the speculation on the origin of the measurement uncertainty, we propose a dual TEM scheme by operating the top TEM in passive mode while its bottom temperature maintains constant by the feedback-controlled bottom TEM. The dual TEM scheme can suppress the sensitivity uncertainty up to 3 times when compared to the single-TEM passive mode by stabilizing the bottom temperature. The response time of a 15 × 15 mm2 TEM is measured to be 8.9 ± 1.0 s for heating and 10.8 ± 0.7 s for cooling, which is slower than commercial heat flux meters but still fast enough to measure heat flux with a time resolution on the order of 10 s. We believe that the obtained results can facilitate the use of a commercial TEM for heat flux measurement in various thermal experiments.