bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicates of personal taste and normative meaning
Authors: Zouhar Marián 
Published: November 2022

AbstractThe main aim of the paper is to reject the idea that predicates of personal taste express normative meanings. According to a recent theory proposed by Daniel Gutzmann, predicates of personal taste express both a truth-conditional content and a use-conditional content, the latter being normative. The purported normativity of predicates of personal taste is supposed to consist in that when producing utterances containing such predicates, their speakers suggest how other people ought to experience the objects of taste under discussion. The paper provides a bunch of evidence to show there are utterances containing predicates of personal taste that cannot be used normatively in this sense. In particular, it is claimed that one can make such an utterance and then add a related normative piece of information without doing anything redundant; one can also make such an utterance and then deny the related normative piece of information without generating any contradiction or infelicity. At the same time, it is admitted there are situations in which the speakers do communicate something normative by producing utterances containing predicates of personal taste. We thus need an explanation to cope with such cases. Although the paper does not offer one, it provides some reasons to the effect that a correct explanation has to be pragmatic rather than semantic.
A Study in brown
Authors: Newall Michael 
Published: November 2022

AbstractPhilosophers rarely write in an extended way about particular colors. So, why write about brown? We shall see that an investigation of brown unsettles some established ideas about color in significant ways. In particular, I will (i) explore reasons for thinking that brown is an elementary color, (ii) reassess attitudes in color science that are taken to rule that possibility out, and (iii) present a new reason for rejecting most forms of color realism.
Protective treatments for copper alloy artworks: preliminary studies of sodium oxalate and limewater effectiveness against bronze disease
Authors: Monari Giulia , Galeotti Monica , Matteini Mauro , Salvadori Barbara , Stifanese Roberto , Traverso Pierluigi , Vettori Silvia , Letardi Paola 
Published: November 2022

AbstractNantokite (CuCl) locked inside subsurface micro-pits has been recognised as the driving force to the form of corrosion called bronze disease. The use of the traditional corrosion inhibitor benzotriazole is questioned because of toxicity. So there is a need for alternative conservation treatments. This work is focused on the experimental design to test the effectiveness of sodium oxalate followed by treatment with limewater to face bronze disease on outdoor bronzes. A number of foundry bronze coupons were exposed to weathering at Genoa Experimental Marine Station (GEMS) exposure site and sprayed twice a week with a 5% NaCl solution for the first 124 days. After 562 days of natural weathering, the patinas on coupons were characterised with non-destructive techniques (NDT) and the presence of nantokite was verified. We designed a workflow, as similar as possible to conservation treatments on real artworks, to test a 3% w/v sodium oxalate treatment with two different application times, with or without limewater, on the coupons. The effectiveness of the treatments was analysed by comparison of surface properties by several NDT measurements. A statistical approach and XRD measurements directly on the corroded bronze surfaces are suggested as an effective way to characterise and compare the overall behaviour of bronze disease treatments for conservation.
Contemporary Data on the Status and Medical Management of Acute Heart Failure
Authors: Bazmpani Maria Anna , Papanastasiou Christos A. , Kamperidis Vasileios , Zebekakis Pantelis E. , Karvounis Haralambos , Kalogeropoulos Andreas P. , Karamitsos Theodoros D. 
Published: November 2022

Abstract
Purpose of Review
Acute heart failure (AHF) is among the leading causes for unplanned hospital admission. Despite advancements in the management of chronic heart failure, the prognosis of AHF remains poor with high in-hospital mortality and increased rates of unfavorable post-discharge outcomes. With this review, we aim to summarize current data on AHF epidemiology, focus on the different patient profiles and classifications, and discuss management, including novel therapeutic options in this area.

Recent Findings
There is significant heterogeneity among patients admitted for AHF in their baseline characteristics, heart failure (HF) aetiology and precipitating factors leading to decompensation. A novel classification scheme based on four distinct clinical scenarios has been included in the most recent ESC guidelines, in an effort to better risk stratify patients and guide treatment. Intravenous diuretics, vasodilators, and inotropes remain the cornerstone of management in the acute phase, and expansion of use of mechanical circulatory support has been noted in recent years. Meanwhile, many treatments that have proved their value in chronic heart failure demonstrate promising results in the setting of AHF and research in this field is currently ongoing.

Summary
Acute heart failure remains a major health challenge with high in-hospital mortality and unfavorable post-discharge outcomes. Admission for acute HF represents a window of opportunity for patients to initiate appropriate treatment as soon as possible after stabilization. Future studies are needed to elucidate which patients will benefit the most by available therapies and define the optimal timing for treatment implementation.
The acquisition of emotion-laden words from childhood to adolescence
Authors: Sabater Lucía , Ponari Marta , Haro Juan , Fernández-Folgueiras Uxia , Moreno Eva M. , Pozo Miguel A. , Ferré Pilar , Hinojosa José A. 
Published: November 2022

AbstractStudies investigating how children acquire emotional vocabularies have mainly focused on words that describe feelings or affective states (emotion-label words, e.g., joy) trough subjective assessments of the children’s lexicon reported by their parents or teachers. In the current cross-sectional study, we objectively examined the age of acquisition of words that relate to emotions without explicitly referring to affective states (emotion-laden words, e.g., cake, tomb, rainbow) using a picture naming task. Three hundred and sixty participants belonging to 18 age groups from preschool to adolescence overtly named line drawings corresponding to positive, negative, and neutral concrete nouns. The results of regression and mixed model analyses indicated that positive emotion-laden words are learnt earlier in life. This effect was independent of the contribution of other lexical and semantic factors (familiarity, word frequency, concreteness, word length). It is proposed that the prioritized acquisition of positive emotion-laden words might be the consequence of the communicative style and contextual factors associated with the interaction between children and caregivers. We also discuss the implications of our findings for proposals that highlight the role of language in emotion perception and understanding.
Mapping of gold mineralization using an integrated interpretation of geological and geophysical data—a case study from West Baranes, South Eastern Desert, Egypt
Authors: Gobashy Mohamed M. , Abbas Ehdaa Allah Sayed , Soliman Khalid S. , Abdelhalim Ahmed 
Published: November 2022

AbstractThe current study is mainly devoted to the integration, analysis, and interpretation of the available geologic, remote sensing, and potential field data (mainly magnetic) to delineate the subsurface geologic structural elements controlling the western part of Baranes, South Eastern Desert, Egypt, and its relation to the southwestern desert structural regime. Additionally, to detect potential mineralization zones for future mining plans in the study area. The Western part of Baranes has not had enough geomorphological mapping, consequently, potential discoveries of mineralization zones are very low. So, in this paper, an attempt is initiated to better understand the evolution of the geomorphology and structural regime of the region and construct a digital geological map and structural patterns showing the possible locations of mineralization zones based on the previous knowledge from similar potential sites and focus on the future economic importance of the region. To achieve this purpose, processed Landsat-8 images successfully revealed the lithological contacts and fault zones helping in distinguishing between the different rock units; moreover, the aeromagnetic data available in the area is used and several filters are applied including reduction to the pole, Euler homogeneity equation, analytic Signal (AS), and advanced grid filtering are sequentially used aiming to detect the possible subsurface distribution of mineralization zones from the integrated interpretation of magnetic susceptibilities and available geologic and remote sensing data.
Cucurbit production systems in Australia and biosecurity risks associated with viral pathogens
Authors: Mulholland S. 
Published: November 2022

AbstractViral infection is a key limiting factor to cucurbit production globally. The viral population within Australia differs from that elsewhere in the world in that it is represented by relatively few key pathogens from a small number of virus families. Viral infections induce a range of physical deformities and discoloration on leaves and fruit of cucurbit commodities. Typically, viral infections result in the decline of marketable yield and even plant death in extreme cases. Identifying key exotic viral issues and the analysis of existing preparedness plans, surveillance programs and diagnostic options are critical biosecurity strategies required to mitigate the introduction of new pathogens into Australia. This review discusses the biosecurity threat exotic viruses pose to Australian cucurbit production systems and the inherent difficulties associated with managing viral pathogens.
Older adults' adaptations to life events: a mobility perspective
Authors: Lowe Thomas A. , de Haas Billie , Osborne Tess , Meijering Louise 
Published: November 2022

AbstractMobility research tends to focus on physical movement and experiences in later life; however, changes in older adult mobility over time remains underexplored. Furthermore, older adults typically experience many life events, some of which result from cognitive and physical decline, and many of which impact mobility. This article aims to explore how life events affect the mobility of older adults over time. We conducted in-depth interviews with 22 older adults aged 55 years and over from Lancashire, United Kingdom. Of these participants, eight lived with memory problems. The findings show that both anticipated and unexpected life events play a profound role in the participants' mobility over time. Retirement, long-term illness and age-related illness were examples of anticipated life events, while the death of a loved one and developing memory problems were examples of unexpected life events. In both cases, participants' made external adaptations, such as moving home, or internal adaptations, such as self-awareness. The findings also emphasise the layered nature of life events and adaptations playing a role in the participants' mobility. Additionally, life events such as developing memory problems showed a domino effect, triggering further life events and adaptations which impacted the participants' mobility. This article emphasises how transition periods can occur before or after a life event, showing that adaptations can be pre-emptive to a life event. Our article contributes to calls for internal adaptations to be fully incorporated into age-related policy and also for age-related policy to be more inclusive for older adults who experience memory problems and dementia.
Early results of Pulsta® transcatheter heart valve in patients with enlarged right ventricular outflow tract and severe pulmonary regurgitation due to transannular patch
Authors: Odemis Ender , Yenidogan Irem , Kizilkaya Mete Han 
Published: November 2022

AbstractObjective:The purpose of this study is to assess the feasibility, effectivity, and safety of a novel self-expandable valve system, Pulsta® transcatheter heart valve in patients with tetralogy of fallot and severe pulmonary regurgitation after transannular patch repair.Background:Severe pulmonary regurgitation after tetralogy of fallot repair is a life-threatening problem and should be treated by pulmonary valve implantation. Although percutaneous pulmonary valve implantation has been ever increasingly used for this purpose, available balloon-expandable valves have limitations and cannot be used by most patients. Pulsta® transcatheter heart valve is a new self-expandable valve system and offers a new solution to be used in patients with different types of native right ventricular outflow tract geometry.Patients and Methods:Ten patients with severe regurgitation after tetralogy of fallot repair with a transannular patch have been enrolled in the study according to echocardiographic examination. MRI was used in asymptomatic patients to delineate the indication and the right ventricular outflow tract geometry. Pulsta® transcatheter heart valve implantation was performed in ten patients, and preprocedural, procedure, and 6 months follow-up findings of the patients were evaluated.Results:Pulsta® pulmonary valve implantation was performed in ten patients successfully without any severe complications. Valve functions were perfect in six of ten patients, while the others had insignificant regurgitation by echocardiographic examination at the end of 6 months follow-up.Conclusions:This study showed that Pulsta® transcatheter heart valve is a feasible, effective, and safe method in the treatment of severe pulmonary regurgitation due to transannular patch repair in patients with tetralogy of fallot.
Article 12 of the Protocol on the Rights of Persons with Disabilities in Africa: A critical analysis
Authors: Tiwa Fomekong Steve 
Published: November 2022

AbstractThis contribution analyses Article 12 of the Protocol to the African Charter on Human and Peoples’ Rights on the Rights of Persons with Disabilities in Africa (the Protocol). It examines the purpose, scope and contribution of this Article to the legal protection of persons with disabilities in armed conflict and its implementation. The analysis is divided into four parts. The first part will start by identifying and analysing the background to this provision, which provides specific protection to persons with disabilities in armed conflict. The second part will examine Article 12 in the light of other similar regional instruments and of the protection challenges that persons with disabilities face during conflict. This will highlight the specific nature of the Article's provisions, together with its shortcomings and its progressive aspects. Part three will look at the interaction between Article 12 and equivalent rules of international humanitarian law, and how Article 12 contributes to the development of legal protection for persons with disabilities in armed conflict. Finally, the fourth part will examine the challenges to the implementation of Article 12. It will also propose ways of overcoming those challenges and hence of enabling Article 12 to have its intended effect.
A Mutual Information Theory‐Based Approach for Assessing Uncertainties in Deterministic Multi‐Category Precipitation Forecasts
Authors: Ning Yawei , Liang Guohua , Ding Wei , Shi Xiaogang , Fan Yurui , Chang Jianxia , Wang Yimin , He Bin , Zhou Huicheng 
Published: November 2022

AbstractThe very nature of weather forecasts and verifications and the way they are used make it impossible for one single or absolute standard of evaluation. However, little research has been conducted on verifying deterministic multi‐category forecasts, which is based on the attribute of uncertainty. The authors propose a new approach using two mutual information theory‐based scores for assessing the comprehensive uncertainty of all categories and the uncertainty for a certain category in deterministic multi‐category precipitation forecasts, respectively. Specifically, the comprehensive uncertainty is defined as the average reduction in uncertainty about the observations resulting from the use of a predictive model to provide all categories forecasts; the uncertainty of a certain category is defined as the reduction in uncertainty about the observations resulting from the use of a predictive model to provide a certain category forecast. By applying the proposed approach and traditional verification methods, the four precipitation forecasting products from the China Meteorological Administration, European Centre for Medium‐Range Weather Forecasts, National Centers for Environmental Prediction, and United Kingdom Meteorological Office were verified in the Dahuofang Reservoir Drainage Basin, China. The results indicate that: (a) the proposed approach can better capture the changing patterns of uncertainties with lead times and distinguish the forecasting performance among different forecast products; (b) the proposed approach is resistant to the extreme bias; (c) the proposed approach needs a careful choice of bin width; and (d) the bias analysis is necessary before verifying the uncertainties in precipitation forecasts.
Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy
Authors: Zhou Jing , Feng Ji , Wu Yong , Dai Hui-Qi , Zhu Guang-Zhi , Chen Pan-Hong , Wang Li-Ming , Lu Guang , Liao Xi-Wen , Lu Pei-Zhi , Su Wen-Jing , Hooi Shing Chuan , Ye Xin-Pin , Shen Han-Ming , Peng Tao , Lu Guo-Dong 
Published: November 2022

AbstractTransarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.
Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia
Authors: Wen Jia , Trost Brett , Engchuan Worrawat , Halvorsen Matthew , Pallotto Linda M. , Mitina Aleksandra , Ancalade NaEshia , Farrell Martilias , Backstrom Ian , Guo Keyi , Pellecchia Giovanna , Thiruvahindrapuram Bhooma , Giusti-Rodriguez Paola , Rosen Jonathan David , Li Yun , Won Hyejung , Magnusson Patrik K. E. , Gyllensten Ulf , Bassett Anne S. , Hultman Christina M. , Sullivan Patrick F. , Yuen Ryan K. C. , Szatkiewicz Jin P. 
Published: November 2022

AbstractTandem repeat expansions (TREs) are associated with over 60 monogenic disorders and have recently been implicated in complex disorders such as cancer and autism spectrum disorder. The role of TREs in schizophrenia is now emerging. In this study, we have performed a genome-wide investigation of TREs in schizophrenia. Using genome sequence data from 1154 Swedish schizophrenia cases and 934 ancestry-matched population controls, we have detected genome-wide rare (<0.1% population frequency) TREs that have motifs with a length of 2–20 base pairs. We find that the proportion of individuals carrying rare TREs is significantly higher in the schizophrenia group. There is a significantly higher burden of rare TREs in schizophrenia cases than in controls in genic regions, particularly in postsynaptic genes, in genes overlapping brain expression quantitative trait loci, and in brain-expressed genes that are differentially expressed between schizophrenia cases and controls. We demonstrate that TRE-associated genes are more constrained and primarily impact synaptic and neuronal signaling functions. These results have been replicated in an independent Canadian sample that consisted of 252 schizophrenia cases of European ancestry and 222 ancestry-matched controls. Our results support the involvement of rare TREs in schizophrenia etiology.
War exposure, post-traumatic stress symptoms and hair cortisol concentrations in Syrian refugee children
Authors: Smeeth Demelza , McEwen Fiona S. , Popham Cassandra M. , Karam Elie G. , Fayyad John , Saab Dahlia , Rieder Michael J. , Elzagallaai Abdelbaset A. , van Uum Stan , Pluess Michael 
Published: November 2022

AbstractAltered secretion of cortisol, the primary effector of the hypothalamus–pituitary–adrenal axis, has been proposed as a means by which traumatic experiences compromise later mental health. However, despite the popularity of cortisol as a potential biomarker for stress and adversity, findings are inconsistent, and little is known about the impact of war-related trauma on stress physiology of children and adolescents. Here we aimed to evaluate the relationships between war exposure, current living conditions, hair cortisol concentrations (HCC) and post-traumatic stress disorder (PTSD) symptoms in a large cohort of Syrian refugee children and adolescents (6–18 years) and their caregiver. This longitudinal observational study assessed Syrian refugee children and adolescents in two waves, 1 year apart, within informal tented settlements in Lebanon. The relationships between war exposure, time since leaving Syria, PTSD symptoms and HCC were investigated using linear mixed-model regression utilising both waves of data collected (Y1: N = 1574, Y2: N = 923). Hair cortisol concentration was positively, but weakly associated with the number of war-related events experienced. This was limited to those who were at least 12 years old at the time of war exposure. Conversely, HCC decreased with time since leaving Syria. HCC was also associated with PTSD symptoms but not with the quality of their current living conditions. This study revealed that changes to hypothalamic-pituitary-adrenal axis activity may accompany both earlier war exposure and current PTSD symptoms in children and adolescents. Additionally, early adolescence may be a particularly sensitive time in terms of trauma-related changes to the hypothalamic-pituitary-adrenal axis.