bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the patient-physician relationships: Tips from a qualitative study
Authors: Bagheri Masood , Somi Mohammad Hossein , Dehghani Gholamali , Ghaffarifar Saeideh 
Published: May 2022

Abstract
Background: Building an effective patient-physician relationship (PPR) is a vital component of successful health care; and educating and preparing students to communicate effectively with patients has always been critical. Such an education and important preparation needs to evaluate the current situation in which the communications are built. The aim of this study was to explore tips for improving PPRs in Tabriz University of Medical Sciences from the perspective of patients, students and faculty members.Methods: In this qualitative content analysis study, data were gathered using focus groups, semi-structured interviews and participatory observations in the field, based on purposive and maximum variation sampling until the saturation was achieved. Content was analyzed through a thematic and manifest analysis. Standards for methodological rigor were enhanced through different strategies.Findings: Content analysis resulted in 36 tips for improving PPRs. The tips were classified at three categories (physician, patient or health system- related factors) and ten sub-categories. Physician-related factors were divided into five sub-categories including personal characteristics; communication competencies; patient-centered practice; professional collaboration and time allotted for a visit. Patient- related factors were distributed into two sub-categories:personal attributes and trust-supported attitude. Health system related factors were alienated into three sub-categories including context-related, socio-cultural and organizational factors. Conclusion: In this study, among the tips to improve the PPRs, the tips allied with physician-related factors were more frequently mentioned by participants. Given this important finding and considering the point that physician-related factors have been less studied in previous studies, interventions focused on physician-related factors are highly recommended.
“Complexity of the male perfume of Eulaema nigrita L. (Apidae: Euglossini) from forest and woody physiognomies of the Brazilian savanna: is there a relationship with body size and wing wear?”,
Authors: Castrillón Kevin Palmera , Toci Aline Theodoro , Augusto Solange Cristina 
Published: May 2022

Abstract
Male orchid bees (Euglossini) collect volatile and semi-volatile compounds from the environment for storage and accumulation in specialized hind legs. Later, these compounds form a perfume blend used during courtship to lure conspecific females for mating. It has been proposed that male orchid bee perfume plays an important role as a sexual signaling trait involved in pre-mating isolation of species, functioning as an indicator of male genetic quality. Eulaema nigrita Lepeletier is a common species in both forested and woody savannah physiognomies (Cerrado sensu stricto) of the Brazilian savanna biome. By identifying the chemical composition of male El. nigrita perfume, we tested for differences in the bouquet chemical profile in populations from remnants of seasonal semideciduous forest and woody savanna. In addition, we assessed the relation between perfume complexity and morphological traits associated with size and age of males. Our analysis showed a low effect of physiognomies on the differences in the perfume chemical profile of sampled males. Nevertheless, we observed significant differences in the chemical profile of individuals from two seasonal semideciduous forest remnants, which a priori suggests an environmental effect in individual bouquet. Wing wear as a morphological measure of age was positively related to perfume complexity, in agreement with the premise that fragrances from older individuals are indicators of survival capacity in male orchid bees.
A clinical classification for radiation-less monitoring of scoliosis based on deep learning of back photographs
Authors: Zhang Teng , Zhu Chuang , Zhao Yongkang , Zhao Moxin , Wang Zhihao , Song Ruoning , Meng Nan , Sial Alisha , Diwan Ashish , Liu Jun , Cheung Jason Pui Yin 
Published: May 2022

Abstract
Routine check-ups for adolescent idiopathic scoliosis are critical to monitor progression and prescribe interventions. AIS is primarily screened via physical examination. If there are features of deformity, radiographs are necessary for diagnosis or follow-up, guiding further management, i.e., bracing for moderate deformity and surgery for severe. However, this subjects children to repetitive radiation and routine practices can be disturbed. Here, we demonstrate a mobile platform powered by ScolioNet, being trained and validated by 1780 back photos with paired radiographs, consisting of heterogeneous severities and curve types, manually annotated by experienced deformity surgeons. In further independent testing on 378 patients, the platform recommended follow-up or surgery with area under curves (AUCs) of receiver operating characteristic curves being 0.839, and 0.902, while distinguishing among thoracic, thoracolumbar/lumbar, or mixed curve types with AUCs of 0.777, 0.760 and 0.860 respectively. Our open platform has potential for out-of-hospital accessible applications in managing children with AIS.
Serum uric acid reflect bone resorption in ankylosing spondylitis patients with low bone mineral density
Authors: yu zou , Li Juan-Juan 
Published: May 2022

Abstract
Objective: To analyze the association between serum uric acid (UA) levels and bone turnover markers. Methods: 62 ankylosing spondylitis (AS) and 50 healthy controls were enrolled. Bone turnover markers were detected by electrochemiluminescence method. The laboratory measurements of AS were collected. The relationship between UA and bone turnover markers were analyzed. Results: The mean level of serum UA was 409.96±93.06 umol/L in healthy controls, and 348.89±68.95 umol/L in AS patents. The levels of UA were significantly higher in healthy controls than in AS patients(P=0.000). In healthy controls, UA was significantly negative correlated with osteocalcin (OC) and C-terminal crosslaps of type I collagen (β-CTX) (P<0.05). However, UA was significantly positive correlated with β-CTX in AS patients with low bone mineral density (BMD). Conclusion: UA could reflect bone resorption in AS patients with low BMD. UA could be used as a marker for the treatment of AS with low BMD and following-up.
A novel conformable fractional grey model for forecasting of CO2 emissions
Authors: Bilgil Halis , Erdinç Ümmügülsüm 
Published: May 2022

Abstract
CO2 emissions in the world have also become one of the most important research topics. In order for policymakers to achieve the goal of reducing carbon emissions and to create environmental policies, it is important to predict how CO2 emissions will progress. The grey modelling in the prediction of time series has been one of the interesting study fields recently due to its efficiency and convenience. Fractional grey models, on the other hand, have become preferable, despite the difficulty in calculations, since they give more effective results than standard models. Difficulties in fractional accumulation and difference calculations have begun to be overcome thanks to new definitions and theorems made in recent years. The new trend in grey modelling is to compose models that are more useful than the previous ones and give results with less error. In this paper, in order to accurately forecast the CO2 emissions, we propose a novel fractional grey model derived from the conformable fractional order and abbreviated as the FEXGM(1,1). The results show that this novel model demonstrates a higher predicted accuracy and more robust performance over the other models considered for comparison.
The Application Value of Nonabsorbent Surgical Suture or Autologous Tendon in the Reconstruction of Medial Patellofemoral Ligament: a randomized controlled trial Protocol
Authors: 潘 林嫄 , Liu Di , Lu Wenhao , Jin Hongfu , Xie Wenqing , Cai Zijun , Xiao Wenfeng , Li Yusheng 
Published: May 2022

Abstract
BackgroundPatellar dislocation is a common knee injury, that often occurs mainly in cases of rupture of the medial patellofemoral ligament (MPFL). Arthroscopic-assisted MPFL reconstruction is a common surgical procedure for patellar dislocation. The grafts commonly used to reconstruct the MPFL include artificial ligament, autologous semitendinosus tendon, thin femoral tendon, patellar ligament, allograft ligament, and popliteal tendon, etc. However, the use of autologous tendons as grafts for MPFL reconstruction may result in hematoma, pain, and delayed recovery at the tendon extraction site. To date, there have been few studies comparing the value of nonabsorbable surgical sutures versus autologous tendons in MPFL reconstruction. Here, we present the protocol of a randomized controlled clinical trial to compare postoperative pain, knee function, and quality of life outcomes of MPFL reconstruction using the two types of grafts mentioned above.MethodThis study is a prospective, randomized, single-blind, controlled clinical trial. Patients who meet the inclusion criteria will be recruited and randomized to MPFL reconstruction using nonabsorbent surgical sutures or autologous tendons. All subjects will be evaluated for imaging, pain, knee function, and quality of life at five-time points: preoperatively and at 1 month, 3 months, 6 months, and 12 months postoperatively. Computed tomography scans will be performed preoperatively and at 12 months postoperatively to assess changes in patellofemoral tilt. Pain assessment is performed using the visual analog score. Knee function will be assessed using the Kujala score, Lysholm score, and IKDC knee function score. Quality of life was assessed using the SF-12 scale.DiscussionThe results of this study will compare the value of nonabsorbent surgical sutures and autologous tendons in MPFL reconstruction and provide a comprehensive assessment of the medium-term prognosis of the study subjects. The results of this study will be used as a reference for future joint surgeons and sports medicine physicians when selecting grafts for MPFL reconstruction for recurrent patellar dislocation.Trial registrationThis study has been registered with the China Clinical Trials Registry (http://www.chictr.org.cn) on March 15, 2022, under the registration number ChiCTR2200057574.
The anti-HIV drug tipranavir induces gastric cancer stem cell apoptosis and exerts anticancer activity via the PRSS23–IL24 pathway
Authors: Xiong Jixian , Li Yuting , Tan Xiangyu , Chen Tie , Liu Baohua , Fu Li 
Published: May 2022

Abstract
Gastric cancer stem cells (GCSCs) contribute substantially to the refractory features of gastric cancer (GC) and are responsible for metastasis, relapse and drug resistance. However, strategies aimed at eliminating GCSCs to improve the clinical outcome of GC patients remain a challenge. Here, we report that tipranavir, a clinically used anti-HIV drug, effectively killed both GCSC and GC cell lines, and inhibited tumor growth in GCSC-derived xenograft models without apparent toxicity. Mechanistic analyses demonstrated that tipranavir induced GCSC cell apoptosis by targeting the novel serine protease PRSS23, releasing MKK3 from the PRSS23/MKK3 complex to activate p38 MAPK, and thereby activating the interleukin (IL) 24-mediated Bax/Bak mitochondrial apoptotic pathway. Tipranavir also killed other types of cancer cell lines and drug-resistant cell lines. Our findings indicate that by targeting both GCSC and GC cells, tipranavir is a promising anti-cancer drug, and the clinical development of tipranavir or other drugs specifically targeting the PRSS23/MKK3/p38MAPK–IL24 mitochondrial apoptotic pathway may offer an effective approach to combat gastric and other cancers.
Bjerknes compensation mechanism as a possible trigger of the low-frequency variability of Arctic amplification
Authors: Latonin Mikhail M. , Bashmachnikov Igor L. , Bobylev Leonid P. 
Published: May 2022

Abstract
The causes of Arctic amplification are widely debated, and a cohesive picture has not been obtained yet. This study has investigated the role of the Atlantic meridional oceanic and atmospheric heat transport into the Arctic in the emergence of Arctic amplification. The integral advective fluxes in the layer of Atlantic waters and in the lower troposphere were considered. The results show a strong coupling between the meridional heat fluxes and regional Arctic amplification in the Eurasian Arctic on the decadal time scales (10–15 years). We argue that the low-frequency variability of Arctic amplification is regulated via the chain of oceanic heat transport – atmospheric heat transport – Arctic amplification. The atmospheric response to the ocean influence occurs with a delay of three years and is attributed to the Bjerknes compensation mechanism. In turn, the atmospheric heat and moisture transport directly affects the magnitude of Arctic amplification, with the latter lagging by one year. Thus, the variability of oceanic heat transport at the southern boundary of the Nordic Seas might be a predictor of the Arctic amplification magnitude over the Eurasian Basin of the Artic Ocean with a lead time of four years. The results are consistent with the concept of the decadal Arctic climate variability expressed via the Arctic Ocean Oscillation index.
Incorporation of SBR Rubber Waste into PVC/CARBONATE Systems
Authors: gonzaga hygo gomes , Morais Crislene Rodrigues da Silva , Cunha Carlos Thiago Cândido 
Published: May 2022

Abstract
The objective of this work was to evaluate the functionalization of the PVC/CARBOBATE polymer system with the addition of SBR and the Polyvinyl chloride-PVC system and CaCO3 carbonate through the incorporation prepared in a torque rheometer. Variations in SBR concentrations in the Poly (vinyl chloride) (C2H3Cl) and CaC03 system under processing conditions to obtain a balance of the mixture in a controlled environment of temperature, time and torque. The mixtures made were characterized and analyzed in terms of their physical and mechanical properties in terms of traction, hardness and fluidity. By FTIR, it was observed that there were no changes in the bands due to the presence of SBR-R in the increase of its percentage of SBR in the PVC/CARBONATE system. The results showed that the addition of rubber residue to the PVC/CARBONATE system causes variations in the mechanical properties of traction and hardness, justifying the reduction of mechanical strength in the addition of rubber to the formulations. XRD reveals the different behavior of the curves, predominantly with low crystallinity in the presence of rubber residue. The behavior of TGA in mass loss in a temperature-controlled atmosphere changes in the flow behavior, presenting lower MFI, leaving the material more viscous and with lower flow in relation to the expected behavior in the injection process. Although the proportions caused changes in the mechanical properties, the results were significantly satisfactory, considering that the composition for the purpose of the study obtained good results. Allowing up to the proportions of 25 and 50% to be applied and alternatives for the development of products with rubber residues according to the desired properties.
Ethnic difference in the rate pressure product recovery to exercise response with African Canadian and South Asian cardiac patients
Authors: Tomlinson Sherldine , Naemi Roozebh 
Published: May 2022

Abstract
Background
The rate pressure product (RPP) is a non-invasive assessment used to predict myocardial oxygen consumption and is defined as the product of heart rate and systolic blood pressure. Studies demonstrating its efficacy with exercise recovery have yielded positive outcomes. Unfortunately, many of the studies conducted are primarily within the European population. Given the lack of research and the difference in exercise responses to other ethnic groups, there is a need to evaluate the RPP in minorities.
Objectives
The study objectives were to 1) compare differences or similarities of low to moderate aerobic exercise to reduce blood pressure and HR in African Canadians and South Asians and 2) identify improvement in RPP values in the two groups.
Methods
One hundred sixty (80 African Canadians and 80 South Asians) with hypertension or related conditions were invited to participate in ten exercise sessions. All participants' blood pressure, heart rate, rate pressure product, pulse pressure, and mean arterial pressure were assessed.
Results
The study showed systolic blood pressure, and heart rate (< 0.05) but not the rate pressure product (p > 0.05) were significantly different between the two groups in pre and post-exercise conditions. While the exercise training improved participants' cardiac markers, the change between the groups was not significantly different.
Conclusion
Our findings align with other studies demonstrating exercise usefulness in lowering BP, but the RPP results were insignificant. The study also highlighted that a community-based exercise intervention could be helpful for specific populations, in this case, African Canadians and South Asians.
Earth engine application to retrieve long-term terrestrial and aquatic time series of satellite reflectance data
Authors: PRASAI RITIKA 
Published: May 2022

Abstract
Google earth engine is an open source cloud based computing platform that is designed to process large scale datasets. Owing to its capacity and features, it can be useful to wide range of applications-the most prominent being vegetation mapping and monitoring, earth sciences related studies and many others. We have developed a web tool based on google earth engine to encourage and assist the researchers from non-programming background to use google earth engine. This application is freely available and can be accessed at https://mapcoordinates.info/. In the current version, this application has some interesting features like data filter, generates time series plots, time series records and metadata in .csv format. Users can download the time series records of any location, select the satellite sensor, choose the model, filter the cloud cover, scale factor. This application also visualizes the time slider feature for the location selected on the map.
Impact of COVID-19 Vaccination on Breast Cancer Patients; the Negative Effects of the Pandemic Have Started to Decrease.
Authors: AVSAR Gokhan , DERYOL Rıza , HAKSEVEN Musluh , CETINDAG Ozhan , TAMAM Selim , UNAL Ali Ekrem , BAYAR Sancar 
Published: May 2022

Abstract
BACKROUND
The COVID-19 pandemic has caused delays in diagnosis, and treatment of breast cancer patients. We predicted that the effects of the pandemic on breast cancer patients would decrease during the post-vaccination period.
METHODS
The data of 131 female patients who were operated on for breast cancer between March 2019, and March 2022, were analyzed into 3 groups: the control group (CG) between March 2019–2020, the pandemic group (PG) between March 2020–2021, and the vaccine group (VG) between March 2021 - March 2022. Patient admission time (PAT), diagnosis time (DT), tumor size, TNM classification and etc data were analyzed.
RESULTS
Prolonged PAT times in PG compared to CG were observed to be significantly reduced in VG (p = 0.009). In both PG and VG, the DTs were prolonged significantly (p < 0.001 and p < 0.001, respectively). Tumor sizes were found to be larger in PG than in CG and VG (p = 0.003 and p = 0.001, respectively).
CONCLUSION
After COVID-19 vaccination; delays in diagnosis and treatment caused by the pandemic in breast cancer patients have decreased and the increase in tumor size during the pandemic period has regressed.
A General Proposition for nth Root (n = odd prime) of a positive real number by the Interval-Weighted Denominator method and determination of 5th and 7th roots as proofs-of-concept
Authors: Iyengar Anju 
Published: May 2022

Abstract
The interval-weighted denominator described previously for square-roots and cube roots of positive real numbers is adapted for the fifth and seventh roots of positive real numbers. This follows from a general proposition for the determination of the nth root (where n = odd prime) of positive real numbers. That combined with square root already described allows for the determination of any natural number root of positive real numbers.
Lumbar vertebrae and epidural space metastases of choriocarcinoma: a case report
Authors: Huang Guangyi , ZHANG WEI , ZHAO ZHI , LI ZHENGWEI 
Published: May 2022

Abstract
Choriocarcinoma is a rare and highly malignant tumor. It is characterized by the production of large amounts of human chorionic gonadotropin (HCG). The lumbar vertebrae and epidural space metastases of choriocarcinoma are extremely rare. The present case report describes a 42-year-old Chinese female patient who was diagnosed as choriocarcinoma of unknown origin with multiple organ metastases, especially in the lumbar vertebral body and epidural space. The patient was admitted to the spine surgery department of The Second Afflicted Hospital of Dalian Medical University with signs of low back pain for ten days, weakness in both lower limbs and dysuria for four days in 2019. Magnetic resonance imaging (MRI) revealed an inhomogeneous nodular lesion in the anterior epidural space from L3 to L4 and an abnormal signal in the L4 vertebral body. The patient underwent emergency surgery on the first day of admission for quick onset of paraplegia and dysuria. But the operation was stopped because of heavy bleeding. Five days later, she underwent embolization of hypervascular lesion of lumbar vertebrae and epidural space. And after this, the mass was subtotally removed. The histopathological diagnosis was choriocarcinoma.
New engineering science insights into the electrodes pairing of electrochemical energy storage devices assisted by machine learning
Authors: Qu Longbing , Wang Peiyao , Motevalli Benyamin , Liang Qinghua , Wang Kangyan , Jiang Wen-Jie , Liu Jefferson Zhe , Li Dan 
Published: May 2022

Abstract
Pairing the positive and negative electrodes with their individual dynamic characteristics properly matched is essential to the optimal design of electrochemical energy storage devices. However, the complex relationship between the performance data measured for individual electrodes and the two-electrode cells used in practice often makes an optimal pairing experimentally challenging. In this work, taking graphene-based supercapacitors as an example, we combine experiments with machine learning to generate a large pool of capacitance data for graphene-based electrode materials with varied slit pore sizes and thicknesses, and numerically pair them into different combinations for two-electrode cells. The as-achieved pairing results allow us to conduct a comprehensive analysis of the correlations between the key electrode structural features of individual electrodes and volumetric capacitance of the resultant two-electrode cells. The results show that the optimal pairing parameters are varied considerably with the operation rate of the cells and are even influenced by the thickness of the inactive components. The best-performing individual electrode does not necessarily result in optimal cell-level performance. The machine learning-assisted pairing approach presents much higher efficiency compared with the traditional trial-and-error approach for the optimal design of supercapacitors and provides an additional effective avenue for further improving the performance of supercapacitors and is expected to play an enabling role in the future on-demand design of energy storage devices. The results observed in this work also indicate the call for comprehensive performance data reporting in the electrochemical energy storage field to enable the adoption of artificial intelligence techniques to accelerate the translation of academic research in this rapidly growing field.