bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comunicación y ética científicas. El falso fraude de las pinturas de Altamira y su representación en el film “Altamira” (2016)
Authors: López Yepes José 
Published: December 2022

Narración del proceso del descubrimiento de las importantes pinturas prehistóricas halladas en 1879 en una cueva de Cantabria (al norte de España) llamada Altamira. Tal descubrimiento, por su elevado valor artístico y su perfección técnica no pudo ser aceptado que fuera cierto por la mayor parte de la comunidad científca del momento encabezada por Cartailhac, arqueólogo francés de gran inﬂuencia. El artículo narra todas las vicisitudes que tuvo que soportar su descubridor, Marcelino Sanz de Sautuola, que fue acusado de superchería y falsifcación de las pinturas. Falleció sin ver reconocido su hallazgo. Con posterioridad, el arqueólogo francés reconoció su error y visitó la cueva y la tumba del erudito español.
Sesame seed protein: Amino acid, functional, and physicochemical profiles
Authors: Yüzer Mustafa , Gençcelep Hüseyin 
Published: December 2022

Sesame (Sesamum indicum L.) is an erect herbaceous annual plant with flat seeds. It is one of the oldest cultivated oilseed plants in the world, especially popular in Africa and Asia.
The present research objective was to describe a sesame protein isolate, i.e., its amino acid profile, functional and physicochemical properties, zeta potential, and hydrodynamic diameter. The surface charge and hydrodynamic diameter in aqueous solutions were obtained for standard sesame seeds, defatted sesame seeds, and the sesame protein isolate.
Defatted sesame seeds yielded the following optimal parameters: salt concentration – 0.6 M, pH – 7, iso-electric point (pI) – 4. The sesame protein isolate was rich in methionine content, which is rare in other plant proteins, but its lysine content was lower than in other isolates. The sesame protein isolate displayed almost identical zeta potential profiles with its pH. The decreasing pH increased the zeta values gradually from the lowest negative value to the highest positive value. The zeta potentials of standard and defatted sesame seeds at pH 7 were –23.53 and –17.30, respectively. The hydrodynamic diameter of the sesame protein isolate (0.33 μm) was smaller than that of sesame seeds (2.64 μm) and defatted sesame seeds (3.02 μm). The sesame protein isolate had a water holding capacity of 1.26 g/g and an oil holding capacity of 3.40 g/g. Its emulsifying properties looked as follows: emulsion capacity – 51.32%, emulsion stability – 49.50%, emulsion activity index – 12.86 m2/g, and emulsion stability index – 44.96 min, respectively. These values are suitable for the sesame protein isolate and are consistent with the literature.
The sesame protein isolate was a good source of protein (88.98%). Using sesame proteins as functional components can be an important basis for better knowledge of the relationship between electrical charge interactions in food matrices and the structure, stability, shelf life, texture, structural and functional properties of food. Research prospects include the effects of sesame protein isolates on various food systems.
IMPLEMENTASI PEMBELAJARAN DARING PADA MATA PELAJARAN PRODUKTIF DI KELAS XI TKRO SMK NEGERI 2 WONOSARI
Authors: Ramadhan Aditya Aditya , Suhartanta Suhartanta 
Published: December 2022

Penelitian ini bertujuan untuk mendeskripsikan implementasi pembelajaran daring pada masa pandemi Covid-19 pada mata pelajaran produktif di kelas XI Teknik Kendaraan Ringan Otomotif (TKRO) SMK Negeri 2 Wonosari yang meliputi aspek perencanaan implementasi pembelajaran daring, pelaksanaan implementasi pembelajaran daring, mengetahui hambatan pembelajaran daring dari perspektif guru dan peserta didik, dan mengetahui solusi guru dalam menghadapi pembelajaran daring. Penelitian ini merupakan penelitian deskriptif. Teknik pengambilan data dengan menggunakan angket. Hasil penelitian menunjukan: (1) aspek perencanaan guru dalam pembelajaran daring pada kategori sangat baik; (2) aspek pelaksanaan pembelajaran dari persepsi guru pada kategori sangat baik sedangkan pelaksanaan pembelajaran daring dari persepsi peserta pada kategori baik; (3) hambatan pembelajaran daring dari persepsi guru dalam kategori tidak ada hambatan. Hambatan pembelajaran daring dari persepsi peserta didik dalam kategori kurang ada hambatan; (4) solusi untuk mengatasi hambatan dalam memeriksa pekerjaan peserta didik dengan menggunakan aplikasi online yang bisa mengolah hasil penilaian secara otomatis seperti halnya google form, kemudian solusi untuk menangani kesulitan peserta didik dalam memahami materi dengan menambahkan video yang mendukung materi yang di berikan.
Audio Visual Digital Preservation Strategies: A case study in National Broadcasting Agency
Authors: Md Alui Siti Eryza Aziera , Khan Mazlina Pati , Shafei @ Safri Nurul Asyiqin , Mohd Nordin Nordiana 
Published: December 2022

This study discusses the digital preservation practice and challenges of the media repository in the broadcasting industry. This study covers the digital preservation practices in Wisma TV, Radio Television Malaysia (RTM) where it functioning as information hubs for media resources and assisting in the preservation of cultural heritage. However, these broadcasting archives have mostly gone unnoticed and neglected by those working in the archive sector. Qualitative research methodology is used by implementing the case study design in order to explored the challenges while performing the digital preservation work. This broadcasting organization media collective was envisioned as a distributed network of organizations that supported media production, exhibition, and study, functioning as resource centers for media and supporting regional preservation efforts.
Keywords: Audiovisual Archiving, Digital Preservation, Broadcasting Industry
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by E-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under the responsibility of AMER (Association of Malaysian Environment-Behavior Researchers), ABRA (Association of Behavioral Researchers on Asians), and cE-Bs (Centre for Environment-Behavior Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
The Prognostic and Predictive Effects of Human Papillomavirus Status in Hypopharyngeal Carcinoma: Population-Based Study
Authors: Yang Shi-Ping , Lin Xiang-Ying , Hu Min , Cai Cheng-Fu 
Published: December 2022

Background
The role of the Human Papillomavirus (HPV) status in patients with hypopharyngeal squamous cell carcinoma (HSCC) remains controversial.

Objective
Our aim was to determine the prognostic and predictive effects of HPV status in patients with locally advanced HSCC (stage III-IVB) receiving primary radiotherapy.

Methods
Patients diagnosed with stage III-IVB HSCC between 2010 and 2016 were identified. HPV status, demographics, clinicopathological characteristics, treatment, and survival data were captured. Kaplan-Meier analysis, multivariable Cox regression analysis, and propensity score matching analysis were performed.

Results
We identified 531 patients in this study and 142 (26.7%) patients with HPV-positive diseases. No significant differences were observed between those with HPV-negative and HPV-positive diseases with regard to demographics, clinicopathological characteristics, and chemotherapy use. HPV-positive HSCC had better head and neck cancer-specific survival (HNCSS; P=.001) and overall survival (OS; P<.001) compared to those with HPV-negative tumors. Similar results were found using the multivariable Cox regression analysis. Sensitivity analyses showed that the receipt of chemotherapy was associated with significantly improving HNCSS (P<.001) and OS (P<.001) compared to not receiving chemotherapy in HPV-negative HSCC, whereas comparable HNCSS (P=.59) and OS (P=.12) were found between both treatment arms in HPV-positive HSCC. Similar results were found after propensity score matching.

Conclusions
Approximately one-quarter of HSCC may be HPV-related, and HPV-positive HSCC is associated with improved survival outcomes. Furthermore, additional chemotherapy appears to be not related to a survival benefit in patients with HPV-positive tumors who received primary radiotherapy.
Trends in Language Use During the COVID-19 Pandemic and Relationship Between Language Use and Mental Health: Text Analysis Based on Free Responses From a Longitudinal Study
Authors: Weger Rachel , Lossio-Ventura Juan Antonio , Rose-McCandlish Margaret , Shaw Jacob S , Sinclair Stephen , Pereira Francisco , Chung Joyce Y , Atlas Lauren Yvette 
Published: December 2022

Background
The COVID-19 pandemic and its associated restrictions have been a major stressor that has exacerbated mental health worldwide. Qualitative data play a unique role in documenting mental states through both language features and content. Text analysis methods can provide insights into the associations between language use and mental health and reveal relevant themes that emerge organically in open-ended responses.

Objective
The aim of this web-based longitudinal study on mental health during the early COVID-19 pandemic was to use text analysis methods to analyze free responses to the question, “Is there anything else you would like to tell us that might be important that we did not ask about?” Our goals were to determine whether individuals who responded to the item differed from nonresponders, to determine whether there were associations between language use and psychological status, and to characterize the content of responses and how responses changed over time.

Methods
A total of 3655 individuals enrolled in the study were asked to complete self-reported measures of mental health and COVID-19 pandemic–related questions every 2 weeks for 6 months. Of these 3655 participants, 2497 (68.32%) provided at least 1 free response (9741 total responses). We used various text analysis methods to measure the links between language use and mental health and to characterize response themes over the first year of the pandemic.

Results
Response likelihood was influenced by demographic factors and health status: those who were male, Asian, Black, or Hispanic were less likely to respond, and the odds of responding increased with age and education as well as with a history of physical health conditions. Although mental health treatment history did not influence the overall likelihood of responding, it was associated with more negative sentiment, negative word use, and higher use of first-person singular pronouns. Responses were dynamically influenced by psychological status such that distress and loneliness were positively associated with an individual’s likelihood to respond at a given time point and were associated with more negativity. Finally, the responses were negative in valence overall and exhibited fluctuations linked with external events. The responses covered a variety of topics, with the most common being mental health and emotion, social or physical distancing, and policy and government.

Conclusions
Our results identify trends in language use during the first year of the pandemic and suggest that both the content of responses and overall sentiments are linked to mental health.
English for tour guide program to improve English Skills of tour guides in Trenggalek’s Tourist Villages
Authors: Wahyuningtyas Dwi , Asih Ria Arista , Maeyangsari Dessy , Fairuzara A. R. Alyaa' Chiquita , Heuvelman Fredik Yunior , Al-Ghaniy Roro Millatu 
Published: December 2022

Trenggalek is one of the potential regencies in East Java, with many beautiful tourist destinations. Realizing this fact, the government of Trenggalek has set a target to develop 100 tourist villages in Trenggalek by 2024. Tourist villages are now becoming one of the main attractions in Trenggalek. To make the villages more known and visited by tourists, some support is needed, one of which is the involvement of tour guides skilled in using English. Therefore, the community service team from UPN "Veteran" Jawa Timur under the scheme PIKAT (Pemanfaatan Ipteks Bagi Masyarakat = Utilization of Science and Technology for Society) held an English for Tour Guide program in Pandean Village, Dongko Sub-district, Trenggalek. Supported by the Department of Tourism and Culture of Trenggalek. This program has been held since July and is still running. The service program consists of three main activities, namely: (1) preparation, debriefing, and pre-departure; (2) implementation; and (3) evaluation. The tour guides joined and attended the program enthusiastically. They were actively involved in the discussions, sharing sessions, and role-plays. It is expected that this program can be impactful for tour guides in tourist villages in Trenggalek and can be extended in a broader scope in the future. In addition, more tourists are interested in visiting Trenggalek, from East Java and around Indonesia.
Development of web-based administration system for Mandeh Pasir Fisherman Group, Marunggi Village, Pariaman City
Authors: Nasir Januardi , Setiawan Yasha Langitta , Yusran Rio Rahmat 
Published: December 2022

As an area close to the sea, the life of the people of Kota Pariaman is highly dependent on marine products. One of the villages in Pariaman City that is very dependent on marine products is the community of Pasir Marunggi Village, South Pariaman District. The strategic location of Pasir Marunggi village, namely the road to go to the Minangkabau international airport and to Pariaman City, automatically makes this village a frequent stopover, especially with the sek rice stalls in Pasir village, which have characteristics with those around Pariaman. Some of the obstacles faced in addition to the lack of knowledge in the field of Information Technology in the process of promoting aquaculture and catches by fishermen, resulting in a decrease in sales turnover for fishermen. This community service was aimed to web-based administration system for Mandeh Pasir Fisherman Group, Marunggi Village, Pariaman City. The computer-based administration system is given because there are still many fishermen who are members of the Mandeh - Fisherman Group who do not understand how to manage a computer-based administration system. The expected result is that business groups can do bookkeeping with a computer by introducing Microsoft Word and Excel for administrative facilities and adding block making training to facilitate the promotion of business groups so that they can be known in other areas and increase revenue turnover.
Concomitant Use of Sulfonylureas and β-Blockers and the Risk of Severe Hypoglycemia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study
Authors: Dimakos Jenny , Cui Ying , Platt Robert W. , Renoux Christel , Filion Kristian B. , Douros Antonios 
Published: December 2022

OBJECTIVE
The hypoglycemic potential of β-blockers among users of sulfonylureas, drugs that strongly increase the risk of this potentially fatal adverse effect, is not well understood. Our population-based cohort study assessed the potential association between concomitant use of sulfonylureas and β-blockers versus use of sulfonylureas alone and the risk of severe hypoglycemia.

RESEARCH DESIGN AND METHODS
Using the U.K. Clinical Practice Research Datalink Aurum, we included patients initiating sulfonylureas between 1998 and 2020, excluding those with β-blocker use in the past 6 months. Time-dependent Cox models estimated hazard ratios (HRs) with 95% CIs of severe hypoglycemia (hospitalization with or death resulting from hypoglycemia; ICD-10 codes E16.0, E16.1, and E16.2) associated with current concomitant use of sulfonylureas and β-blockers compared with current sulfonylurea use alone, adjusted for baseline confounders. We also compared current concomitant use of sulfonylureas and non-cardioselective versus cardioselective β-blockers.

RESULTS
Our cohort included 252,869 initiators of sulfonylureas (mean age 61.3 years; 43% female). Median follow-up was 7.9 years. The crude incidence rate of severe hypoglycemia was 7.8 per 1,000 per year. Concomitant use of sulfonylureas and β-blockers was associated with an increased risk of severe hypoglycemia compared with sulfonylurea use alone (HR 1.53; 95% CI 1.42–1.65). There was no difference in the risk between concomitant use of sulfonylureas and noncardioselective β-blockers and concomitant use of sulfonylureas and cardioselective β-blockers (HR 0.95; 95% CI 0.74–1.24).

CONCLUSIONS
β-blockers could further increase the risk of severe hypoglycemia when used concurrently with sulfonylureas. β-blocker cardioselectivity did not seem to play a major role in this regard.
Identification of genetic variation influencing metformin response in a multi-ancestry genome-wide association study in the Diabetes Prevention Program (DPP)
Authors: Li Josephine , Perry James A. , Jablonski Kathleen A. , Srinivasan Shylaja , Chen Ling , Todd Jennifer N. , Harden Maegan , Mercader Josep M. , Pan Qing , Dawed Adem Y. , Yee Sook Wah , Pearson Ewan R. , Giacomini Kathleen M. , Giri Ayush , Hung Adriana M. , Xiao Shujie , Williams L. Keoki , Franks Paul W. , Hanson Robert L. , Kahn Steven E. , Knowler William C. , Pollin Toni I. , Florez Jose C. , Group Diabetes Prevention Program Research 
Published: December 2022

<p>Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not replicated in the Diabetes Prevention Program (DPP). To assess pharmacogenetic interactions in pre-diabetes, we conducted a genome-wide association study (GWAS) in the DPP. Cox proportional hazards models tested associations with diabetes incidence in metformin (MET, n=876) and placebo (PBO, n=887) arms. Multiple linear regression assessed association with one-year change in metformin-related quantitative traits, adjusted for baseline trait, age, sex, and 10 ancestry principal components. We tested for gene-by-treatment interaction. No significant associations emerged for diabetes incidence. We identified four genome-wide significant variants after correcting for correlated traits (<em>p</em><9×10-9). In MET, rs144322333 near <em>ENOSF1 </em>(minor allele frequency [MAF]AFR=0.07, MAFEUR=0.002) was associated with an increase in % glycated hemoglobin (per minor allele β=0.39 [95% CI 0.28, 0.50], <em>p</em>=2.8×10-12). Rs145591055 near <em>OMSR</em> (MAF=0.10 in American Indians), was associated with weight loss (kg) (per G allele β=-7.55 [95% CI -9.88, -5.22], <em>p</em>=3.2×10-10) in MET. Neither variant was significant in PBO; gene-by-treatment interaction was significant for both variants (<em>p(G×T)</em><1.0×10-4). Replication in individuals with diabetes did not yield significant findings. A GWAS for metformin response in pre-diabetes revealed novel ethnic-specific associations that require further investigation but may have implications for tailored therapy. <br>
</p>
Video Pembelajaran Berbasis Lingkungan Dalam Pembelajaran IPA Kelas IV SD
Authors: Komang Rizky Aditya Wiguna  , Ndara Tanggu Renda  , Kadek Yudiana  
Published: December 2022

Saat ini banyak guru yang hanya mengandalkan gambar pada buku dalam pembelajaran IPA. Hal ini membuat siswa sulit memahami pelajaran. Oleh karena itu diperlukan pengembangan media pembelajaran yang mampu membantu pemahaman siswa. Penelitian ini bertujuan untuk mengembangkan media video pembelajaran berbasis lingkungan rumah sekitar muatan IPA tema 4 SD. Rancangan penelitian yang akan digunakan adalah penelitian pengembangan model ADDIE. Subjek penelitian ini adalah video pembelajaran berbasis lingkungan rumah sekitar tema 4. Data video pembelajaran berbasis lingkungan rumah sekitar tema 4 dikumpulkan dengan menggunakan angket. Data dianalisis dengan menggunakan uji validitas. Berdasarkan hasil evaluasi dari (1) ahli materi diperoleh persentase tingkat pencapaian yaitu 92 % yang berada pada kualifikasi sangat baik, (2) ahli media pembelajaran diperoleh persentase tingkat pencapaian yaitu 96 % dan berada pada kualifikasi baik, (3) uji coba perorangan diperoleh persentase tingkat pencapaian dari guru yaitu 96 % dan berada pada kualifikasi sangat baik. Penggunaan modul yang dikembangkan efektif digunakan untuk mendukung pembelajaran berbasis lingkungan rumah sekitar tema 4.
KONTRIBUSI PENGETAHUAN KESEHATAN DAN KESELAMATAN KERJA (K3) DAN SIKAP KERJA TERHADAP HASIL BELAJAR MATA PELAJARAN PRODUK DAN KREATIF KEWIRAUSAHAAN SISWA KELAS XI TEKNIK PERMESINAN DI SMK NEGERI 1 PADANG
Authors: Arrafi Miftahul , Erizon Nelvi , Arwizet Arwizet , Primawati Primawati 
Published: December 2022

K3 (Keselamatan dan Kesehatan Kerja) adalah gagasan yang berupaya menjamin integritas fisik dan mental. Penelitian dilakukan mengungkapkan dampak terhadap kontribusi peserta didik pada pengetahuan K3 dan sikap kerja pada hasil belajar produk kreatif, dan kewirausahaan di SMKN Negeri 1 Padang. Jenis penelitian yang dipakai ialah research korelasional melihat besaran kontribusi pada variabel. Penelitian dilaksanakan pada SMKN Negeri 1 Padang bertempat di Jl Mahmud Yunus Anduring, Kecamatan Kuranji, Kota Padang, Sumatera Barat. Teknik pengambilan sampel memakai sampel sebanyak 61 orang terdiri 2 kelas yaitu, kelas XI-TP-A dan XI-TP-B. Teknik pengumpulan data diambil menggunakan angket yang disebarkan ke peserta didik. Metode yang dipakai yaitu metode kuantitatif yang bersifat korelasional dengan cara pengumpulan data melalui instrument angket dan dokumentasi hasil nilai uji reliabilitas dan validitas. Teknik analisis reseach memakai teknik pra analisis, uji normalitas, uji linearitas, uji heterokedastisitas, dan uji multikolinearitas. Untuk uji hipotesis memakai teknik moment product correlation. Berdasarkan penelitian uji korelasi Ketika nilai pengetahuan dan sikap kerja bernilai 0, maka (siswa) secara konstan memiliki nilai sebesar 73,049. Ketika nilai Pengetahuan K3 bernilai satu satuan dan Sikap Kerja bernilai 0, maka nilai siswa akan meningkat sebesar -0,106. Ketika nilai Pengetahuan K3 bernilai 0 dan Sikap Kerja bernilai satu satuan, maka nilai siswa akan berkurang sebesar 0,172.
HUBUNGAN PRESTASI BELAJAR, DUKUNGAN SOSIAL ORANG TUA DAN EKSPEKTASI KERJA TERHADAP MINAT MELANJUTKAN STUDI S2 PADA MAHASISWA PENDIDIKAN TEKNIK MESIN FT UNP
Authors: Azhar Alfian , Ambiyar Ambiyar , Irzal Irzal , Mulianti Mulianti 
Published: December 2022

Penelitian bertujuan mengungkapkan hubungan prestasi belajar, social support orang tua dan harapan bekerja pada minat melanjutkan studi S2 pada mahasiswa Pendidikan Teknik Mesin FT-UNP. Jenis penelitian yang diberlakukan ialah quantitative research. Subjek penelitian ialah mahasiswa Pendidikan Teknik Mesin Angkatan 2018 FT-UNP sebanyak 76 mahasiswa. Teknik pengumpulan data memakai kuisioner (angket) dan dokumentasi. Teknik analisis data memakai metode correlational analysis. Hasil penelitian memperlihatkan: 1) Tidak terdapat hubungan prestasi belajar pada minat lanjut studi S2 pada mahasiswa pendidikan teknik mesin FT-UNP yang ditunjukan dengan nilai koefisien korelasi (r)= 0207, 2) terdapat adanya keterikatan hubungan dorongan sosial orang tua pada minat melanjutkan studi S2 peserta didik Pendidikan Teknik Mesin FT UNP yang diperlihatkan pada nilai korelasi koefisien (r) = 0,346, 3) dihubungan ekspektasi kerja pada minat melanjutkan studi S2 diperlihatkan dengan penilaian korelasi koefisien (r)= 0,314, 4) tampak hubungan prestasi belajar, social support orang tua dan harapan bekerja dengan bersama pada minat lanjut studi pascasarjana S2 peserta didik Pendidikan Teknik Mesin FT-UNP yang ditunjukkan dengan koefisien determinasi (R2)= 0,191. Nilai Sumbangan Relatif X1= 6,9%, X2=51,1%,X3=41,8%, dan total sumbangan efektif yaitu 19,1%. Hasil dari penelitian ini mengharapkan mahasiswa Pendidikan Teknik Mesin memiliki ketertarikan untuk lanjut pendidikan ke jenjang yang lebih tinggi yaitu pascasarjana (S2).