bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hihger Oder Extended Block Hybrid Second Derivatives Backward Differentiation Formula for Solving Dae of Index 1,2, and 3 R. A. Soneye, O. A. Akinfenwa, R. I. Abdulganiy and S. A. Okunuga
Authors: AKINFENWA OLUSEYE AREMU , OKUNUGA SOLOMON ADEBOLA , ABDULGANIY RIDWAN IYANDA 
Published: August 2022

Abstract

A new two-step Extended Second Derivative Hybrid Block Backward Differentiation Formula (ESDHBBDF) for the solution of Differential-algebraic Equations (DAEs) of index-1, 2, and 3 systems is presented. The derived methods which were coupled and implemented as a set of block formulae was implemented in a block by block fashion. Numerical results obtained when tested on some standard DAEs of index- 1, 2, and 3 with wider range revealed that the method was efficient and very accurate, and particularly suitable for DAEs.
Investigation of photocatalytic activity (under visible light) of ultrathin CZTS films produced in different thicknesses by PLD method
Authors: Dursun Sami , Sarıipek Fatma Bayram , Kılıç Sümeyye , Gezgin Serap Yiğit , Gündoğdu Yasemin , Kılıç Hamdi Şükür 
Published: August 2022

Abstract
Cu2ZnSnS4 material has been produced by Pulsed Laser Deposition (PLD) on Soda Lime Glass (SLG) substrates as a function of the number of laser pulses. As the deposition of ablated material has been augmented with increasing number of laser pulses, it has been observed that CZTS-ultrathin film’s thicknesses and particle sizes have been increased, their crystalline structures have been improved. Larger particles limit the transmission of light and cause thin films to absorb more photons. Therefore, band gaps of CZTS-ultrathin films have been reduced. CZTS (61 nm) ultrathin film with the thinnest one among the thin films produced in this work, which is Cu and S poor but Sn and Zn rich. By increasing the thickness of the film, it has been observed that the amount of Cu and S were increased, and the ratio of Sn and Zn were decreased. In addition, it has been systematically investigated that the photocatalytic activity of the ultra-thin CZTS films coated in different thicknesses by PLD method. Among all the photocatalysts, the CZTS (in 242 nm thickness) photocatalyst has exhibited the highest photocatalytic performance, managing to remove 96.1% of methylene blue (MB) in 240 min. Furthermore, the mechanism that performs photocatalysis has been investigated by scavenger experiments, and it was observed that radical ions have an important role in the reaction, while holes have little effect.
CCL4 participates in the reprogramming of glucose metabolism induced by ALV-J infection in chicken macrophages
Authors: Luo Huan , Wu Huixian , Zhu Shutong , Zhu Zhijian , Wang Chenjun , Huang Hongao , Chen Shihao , Cui Hengmi , Chai Wenxian , Hu Xuming 
Published: August 2022

Abstract
Interferons and chemokines-mediated immune responses are two general antiviral programs of the innate immune system in response to viral infections and have recently emerged as important players in systemic metabolism. In this study, we found that the chemokine CCL4 is negatively regulated by glucose metabolism and avian leukosis virus subgroup J (ALV-J) infection in chicken macrophages. This immune response is defined by low expression levels of CCL4 by high glucose treatment or ALV-J infection. Moreover, the ALV-J envelope protein is responsible for CCL4 inhibition. We further confirmed that CCL4 can inhibit glucose metabolism and ALV-J replication in chicken macrophages. The present study provides novel insights into the antiviral defence mechanism and metabolic regulation of the chemokine CCL4 in chicken macrophages.
Pelvic floor physical therapy in patients with chronic anal fissure: Long term follow-up of a randomized controlled trial
Authors: Reijn-Baggen Daniëlle A. van , Elzevier Henk W. , Putter Hein , Pelger Rob C.M. , Han-Geurts Ingrid J.M 
Published: August 2022

Abstract
Background Chronic anal fissure is a common benign anorectal disease with a high recurrence rate. Pelvic floor physical therapy has been proven effective in the short-term management in patients with chronic anal fissure and pelvic floor dysfunction (PAF-trial). The aim of this study was to determine the outcomes of the PAF-trial and fissure recurrence in patients who completed the 2 months of pelvic floor physical therapy at 1-year follow-up.Methods Electromyographic registration of the pelvic floor, digital rectal examination, visual analog scales, patient related outcome measurements and quality of life were assessed at baseline, and at 1 year after inclusion. The primary outcome was muscle tone at rest during electromyographic registration of the pelvic floor at baseline and at 1-year follow-up. Secondary outcomes contained fissure recurrence, pain ratings, pelvic floor dysfunction, complaint reduction measured with a proctology specific patient-reported outcome measurement and quality of life. Results The treatment protocol was followed by 137 patients. 97 patients (71%) completed the 1-year follow-up, 48 women (49.5%) and 49 men (50.5%) with a mean age of 44,4 ±11.6 years (range 19-68). In the total group of patients, mean resting electromyographic values of the pelvic floor significantly improved from baseline to follow-up at 1 year (mean estimated difference 2.20 µV; 95% CI, 1.79 to 2.61; p<0.001). After 1 year, the fissure recurred in 15 patients (15.5%). VAS-pain significantly decreased from baseline to follow-up (mean estimated difference 4.16; 95% CI, 3.75 to 4.58; p<0.001). Dyssynergia was found in 72.9% at baseline and decreased to 14.4% at 1-year follow-up (p<0.001). Complaint reduction measured with the Proctoprom, significantly improved from baseline to 1-year follow-up (p<0.001). Quality of life (RAND-36) significantly improved in eight of nine domains at 1-year follow-up. No significant improvement was found in the domain vitality.Conclusions In the PAF-trial, we demonstrated that pelvic floor physical therapy yields a significant and clinical benefit in the time course and therefore should be advocated as adjuvant conservative treatment in patients with chronic anal fissure.
Comparison of preservation, dissection of 50% and 100% inferior pulmonary ligament during video-assisted thoracoscopic surgery in upper lobectomy of lung cancer
Authors: Kang Jianhong , Abudurufu Maimaiti , Zhang Shuwei , Luo Honghe , Jiang Wei 
Published: August 2022

Abstract
Background
Preservation or dissection of the inferior pulmonary ligament (IPL) during performing upper lobectomy by video-assisted thoracoscopic (VATS) remains controversial. Also, whether dissecting 50%IPL can combine the advantages of both preservation and dissection or not remains controversial as well. This retrospective study analyzed the short-term clinical effects of preservation, dissection of 50%IPL, and dissection of 100%IPL during VATS for upper lobectomy.
Methods
A total of 104 patients with lung cancer who underwent VATS of upper lobectomy from May 2019 to December 2020 were selected and divided into three groups, 34 cases of preserving IPL as control group A, 35 cases of dissecting 50% IPL as group B, and 35 cases of dissecting 100% IPL as group C. This study mainly analyzed surgery time, intraoperative blood loss and intraoperative infusion volume, postoperative outcomes such as drainage time, hospital stay, and complications such as atelectasis, pneumothorax, pleural effusion, and white blood cell count (WBC), and neutrophils (NEU) in these cases.
Results
No significant differences were identified in surgery time(P = 0.526). Intraoperative blood loss was significantly lower in groups B and C than in group A (P = 0.000). Intraoperative infusion volume in group B was significantly lower than that in group C and group A (P = 0.009). The postoperative drainage time of group B was similar to that in group C, and was significantly lower than that of group A (P = 0.001). Group B had the shortest duration of postoperative hospital stay, and group C was slightly lower than group A (P = 0.001). No significant differences were demonstrated in atelectasis, pneumothorax, pleural effusion, postoperative WBC and postoperative NEU (P = 0.133,0.596,0.361,0.305, and 0.278 respectively). However, the prevalence of total complications in group B was the lowest, and in Group C was slightly lower than that in group A (P = 0.038). The results were similar in the left and right upper lungs.
Conclusions
The drainage time, hospital stay, and postoperative complications of dissecting 50%IPL were less than those of dissecting 100%IPL and IPL preservation. The intraoperative blood loss and postoperative drainage time of dissecting 100%IPL were slightly lower than preservation, and the intraoperative infusion volume and complications were similar to preservation.
High resolution mutated dynamic precision power gated comparator for 9-bit SAR ADC
Authors: Thamaraimanalan T. , Venkatesan C. 
Published: August 2022

Abstract
Comparator design is a major challenge during the implementation of high resolution SAR ADCs. In this research, a mutated dynamic power gated comparator is designed to achieve the SAR ADC with ultra-low power and enhanced gain. The proposed power gated comparator is designed using 45nm CMOS technology, and it is tested at 3.3V and 5V. High speed and low power are achieved through transistor sizing and power gating techniques. Mismatch of transistors, the offset value is appropriately calculated using the input resistance of the differential amplifier and trans conductance. Also, the offset cancellation and digital calibration techniques are included in the design to enhance the precision, and to improve the performance of ADCs. For the proposed comparator, phase margin, gain, ICMR, power consumption, offset voltage, slew rate, load capacitance, propagation delay, kickback noise, and settling time are compared with the conventional comparator. The proposed design consumes only 4.2mW while operating at 5V and 1.5mW when the input voltage is 3.3V. The effective resolution of the SAR ADC is observed as 8.2 bit with the proposed power gated comparator.
Producing of high-transparent antiscratch nanohybrid thin films on polycarbonate substrate
Authors: Kiomarsipour Narges , Eshaghi Akbar , Ramazani Mazaher , Zabolian Hosein , Abbasi-Firouzjaha Marzieh 
Published: August 2022

Abstract
In the present work, a new aqueous sol–gel procedure has been used for producing hard transparent organic–inorganic nanohybrid coatings on polycarbonate (PC) substrate for improving its optical and mechanical properties. Sol-gel thins films were prepared by mixing Si and Al aqueous precursors and applied them on the cold plasma treated PC substrate. TEOS, GPTMS and aluminum tri sec-butoxide were used as main precursors. In order to improve the adhesion strength onto polymer, PC substrates were treated by Dielectric Barrier Discharge (DBD) system being conducted at atmosphere pressure in open air. The effects of sol ratios, curing temperature and aging time on the prepared coatings properties were investigated. Chemical, structural, morphological, optical and mechanical characteristics of the samples were studied by ATR-FTIR, EDS, XRD, FE-SEM, TEM, UV/vis spectroscopy, pencil hardness and eraser scratch methods. The obtained results indicated that the water contact angle of PC (73.24°) decreased to 6.32° by 45 second plasma treatment due to added functional groups on the treated surfaces. All of the films showed higher optical transmittance (89%) than the raw PC (86%) that was stemmed from the lower refractive index of the prepared films. Films indicated good adhesion onto the plasma treated substrates (5B). The pencil hardness of the PC substrate (4B) improved to 3H (8 pencil grade increment) with just a single layer coating (about 200 nm thickness) due to the preparation of new hard structures of interlocked Si and Al atoms.
Honey origin authentication using cyclic voltammetry and nanostructured carbon electrodes
Authors: Anizelli Camilla Pastore , Santos Luana Dalagrana dos , Ribeiro Vítor Antônio Vitale , Scholz Maria Brígida dos Santos , Killner Mario Henrique Montazzolli , Dias Luís Avelino Guimarães , Bona Evandro 
Published: August 2022

Abstract
Honey is a sweet substance that bees produce from the nectar of flowers. The geographic origin is an intrinsic factor for the characteristics of honey, which are evaluated through physicochemical analyzes that demand high analysis time and cost. Cyclic voltammetry can be used as an alternative analytical tool for the discrimination of honey samples, being a fast, simple, and inexpensive technique. This study aimed to apply cyclic voltammetry for honey origin authentication from Ortigueira (Paraná – Brazil) using graphite electrodes modified with nanoparticles of nickel oxide, iron oxide, copper oxide, and carbon nanotubes. The voltammograms collected were treated using chemometric methods for exploratory analysis and classification. The principal component analysis (PCA) demonstrated that cyclic voltammetry had better discrimination performance than the physicochemical analysis. The best classification model (PLS-DA) was also obtained with data from cyclic voltammetry with a percentage of correct classification for the prediction set of 94.44%. On the other hand, the PLS-DA model with physicochemical data achieved 88.57% of correct classification in the prediction set. The PLS-DA model using the voltammograms obtained with the developed electrodes showed more accuracy and greater selectivity when compared to the PLS-DA model built with the physicochemical data. Furthermore, the electrochemical system developed has low cost and allows quick analyzes that can be applied to verify the authenticity of the geographical origin of honey samples.
Obesity is associated with a distinct innate immune phenotype in severe COVID-19 patients
Authors: Resende Ayane , de Oliveira Yrna Lorena , de Franca Mariana , Correa Cristiane , Fukutani Kiyoshi , Lipscomb Michael , de Moura Tatiana 
Published: August 2022

Abstract
Background/Objectives: Obesity is a chronic inflammatory disease that may impair immunity against SARS-Cov-2 in severe disease states. This study investigated whether the innate immune compartment is associated with obesity in severe COVID-19.Methods: This cross-sectional study enrolled twenty-seven ICU COVID-19 patients that were assigned to obese (BMI≥30 kg/m², n=9) and non-obese (BMI<30kg/m², n=18) groups. Thirteen non-obese healthy adults composed the control group. Monocytes, NK, and both Low-Density (LD) and High-Density (HD) neutrophils were isolated from peripheral blood samples and analyzed by flow cytometry to evaluate the frequency and expression patterns of surface receptors associated with innate immune effector responses. sTREM-1 and IL-6 levels from patients’ sera were quantified by ELISA. Results: The frequency of monocytes was negatively correlated with BMI, while NK and neutrophils were positively associated (p<0.05). A reduction of peripheral monocytes was observed in obese patients, and these cells showed a higher expression of PD-L1 than non-obese (p=0.04). HLA-DR expression on CD14+ monocytes was negatively associated with BMI (p=0.03) and total leukocytes (p=0.005). Patients with obesity also demonstrated a higher frequency of NK cells (p=0.01) and a hyperactivated phenotype (CD16+CD182+TREM-1+) in HD neutrophils (p=0.01). This phenotype was positively correlated with total leukocytes (p=0.01) and negatively correlated with the total numbers of HLA-DR+ monocytes in obese group (p=0.001). An increased expression of CD16 (p=0.01) and TREM-1+ (p=0.005) on mature HD neutrophils was detected in obese patients. In this group, CD16 was negatively correlated with IL-6 levels (p=0.03) and TREM-1+ positively correlated with PD-L1 on neutrophils (p=0.03). Furthermore, sTREM-1 levels correlated with PD-L1 of monocytes and LD neutrophils (p=0.02). Finally, aging may exacerbate cytotoxic and suppressive activity. Conclusion: Our data support that obesity differentially affected innate immune response in severe COVID-19 and highlight immune markers that should be further investigated as predictors for monitoring treatment in severe patients with comorbidities.
IPTS-TiO2 treated wood with anti-weathering properties by UV shielding
Authors: Shi Danchen , Wang Wenxuan , Liang Daxin , He Zengcheng , Wang Yonggui , Xiao Zefang , Yu Yang , Wang Haigang , Xie Yanjun 
Published: August 2022

Abstract
Plantation poplar is one of the most commonly used fast-growing woods in China. However, it can be easily weathered by climatic conditions (such as sunlight irradiation, rain, temperature change and oxidation), resulting in the degradation of wood properties. UV-induced discoloration is a noticeable issue to wood for outdoor use. In this study, titanium dioxide (TiO2) nanoparticles were modified onto the surface of wood via 3-isocyanatopropyltriethoxysilane (IPTS) bridge. Artificial accelerated QUV weathering tests were carried out to evaluate the anti-weathering properties after IPTS-TiO2 modification. During treatment, TiO2 nanoparticles were bonded with IPTS and grafted onto the wood surface with isocyanate group. TiO2 nanoparticles played a role as UV filter, reducing degradation, and IPTS helped reduce the discoloration of wood. From FTIR results, the photodegradation of lignin was inhibited effectively during the weathering process. After artificial weathering, the values of L*, a* and b* of the IPTS-TiO2 treated wood were 80.16, 5.27 and 21.06, respectively. The results suggest the feasibility of IPTS-TiO2 modification for improving the anti-weathering properties of polar wood and providing an effective strategy for industrial wood modification.
Comprehensive Analyses of One-carbon Metabolism Related Genes and Their Association with Prognosis, Tumor microenvironment, Chemotherapy Resistance and Immunotherapy in Lung Adenocarcinoma
Authors: Zhou Ning , Tang Quanying , Yu Haochuan , Li Tong , Ren Fan , Zu Lingling , Chen Gang , Chen Jun , Xu Song 
Published: August 2022

Abstract
Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer and is a global public health concern. One-carbon (1C) metabolism plays a crucial role in the occurrence and development of multiple cancer types. However, there are limited studies investigating 1C metabolism in LUAD. This study aims to evaluate the prognostic value of 1C metabolism-related genes in LUAD and to explore the potential correlation of these genes with gene methylation, the tumor microenvironment, and immunotherapy.Methods: We identified 26 1C metabolism-related genes and performed a Kaplan-Meier and Cox regression analysis to evaluate the prognostic value of these genes. Consensus clustering was further performed to determine the 1C metabolism-related gene patterns in LUAD. The clinical and molecular characteristics of subgroups were investigated based on consensus clustering. CIBERSORT and ssGSEA algorithms were used to calculate the relative infiltration levels of multiple immune cell subsets. The relationship between 1C metabolism-related genes and drug sensitivity to immunotherapy was evaluated using the CellMiner database and IMvigor210 cohort, respectively.Results: The expression levels of 23 1C metabolism-related genes were significantly different between LUAD tumor tissues and normal tissues. Seventeen of these genes were related to prognosis. Two clusters (cluster 1 and cluster 2) were identified among 497 LUAD samples based on the expression of 7 prognosis-related genes. Distinct expression patterns were observed between the two clusters. Compared to cluster 2, cluster 1 was characterized by inferior overall survival (OS) (median OS= 41 vs. 60 months, p=0.00031), increased tumor mutation burden (15.8 vs. 7.5 mut/Mb, p<0.001), high expression of PD-1 (p<0.001) and PD-L1 (p<0.001), as well as enhanced immune infiltration. 1C metabolism-related genes were positively correlated with the expression of methylation enzymes, and a lower methylation level was observed in cluster 1 (p=0.0062). Patients in cluster 1 were resistant to chemotherapy drugs including pemetrexed, gemcitabine, paclitaxel, etoposide, oxaliplatin, and carboplatin. The specific expression pattern of 1C metabolism-related genes was correlated with a better OS in patients treated with immunotherapy (median OS: 11.2 vs. 7.8 months, p=0.0034). Conclusions: This study highlights that 1C metabolism is correlated with the prognosis of LUAD patients and immunotherapy efficacy. Our findings provide novel insights into the role of 1C metabolism in the occurrence, development, and treatment of LUAD, and can assist in guiding immunotherapy for LUAD patients.
Overweight or Obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: A Bayesian survival analysis from the Hunter Community Study.
Authors: McEvoy Mark , Wynne Katie , Attia John , Oldmeadow Christopher , Inder Kerry , Kelly Brian , Hancock Stephen , Opio Jacob 
Published: August 2022

Abstract
Objective
To estimate the risk of cardiovascular disease (CVD) in older adults with overweight or obesity without metabolic risk factors using a Bayesian survival analysis.
Design:
Prospective cohort study with median follow-up of 9.7 years.
Setting:
Newcastle, New South Wales, Australia.
Participants
: A total of 2313 community-dwelling older men and women.
Intervention/exposure:
Participants without known CVD and with a body mass index (BMI) ≥ 18.5 kgm2 were stratified by BMI and metabolic risk to create six BMI-metabolic health categories. Metabolic risk was defined according to the International Diabetes Federation criteria for metabolic syndrome. “Metabolically healthy” was defined as absence of metabolic risk factors. Bayesian survival analysis, incorporating prior information from a previously published meta-analysis was used to assess the effect of BMI-metabolic health categories on time from recruitment to CVD.
Main Outcome:
Incident physician-diagnosed CVD, defined as fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, angina, or coronary revascularisation procedure, was determined by linkage to hospital admissions records and Medicare Australia data. Secondary outcomes were cardiovascular mortality and all-cause mortality.
Results
From 2313 adults with complete metabolic health data over a median follow-up of 9.7 years, 283 incident CVD events, 58 CVD related deaths and 277 deaths from any cause occurred. In an adjusted Bayesian survival model of complete cases with informative prior and metabolically healthy normal weight as the reference group, the risk of CVD was increased in metabolically healthy overweight (HR = 1.52, 95% credible interval 0.96–2.36), and in metabolically healthy obesity (HR = 1.86, 95% credible interval 1.14–3.08). Imputation of missing metabolic health and confounding data did not change the results.
Conclusion
There was increased risk of CVD in older adults with overweight or obesity, even in the absence of any metabolic abnormality. This argues against the notion of “metabolically healthy” overweight or obesity.