bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Clinical and Patient-Reported Outcomes Following the Brostrom-Gould Procedure
Authors: Shah Ashish , Young Sean M. , Sanchez Thomas , Sankey Turner , Littlefield Zachary , Wordekemper Jordan , Boyd Brandon , Luque-Sanchez Kevin S. , Young Matthew , Prahad Srihari R. 
Published: November 2022

Category: Ankle; Sports; Trauma Introduction/Purpose: Chronic ankle instability (CAI) is a commonly encountered condition amongst foot and ankle surgeons and is characterized by loss of function and stability of the ankle following multiple or poorly healed ankle sprains. The Brostrom- Gould procedure is a widely accepted method of addressing CAI and has been seen to produce favorable outcomes in terms of regaining ankle function and stability. While long-term clinical results of the Brostrom-Gould procedure exist in the literature, there is little published on long-term patient-reported outcomes. Methods: Patients that underwent the Brostrom-Gould procedure from 2011 to 2015 were identified. The electronic medical record was utilized to collect patient demographics, preoperative and postoperative diagnosis, and clinical outcomes. Patients were then surveyed to obtain PROMIS domain scores (physical function, pain interference, and depression), resiliency scores, foot and ankle ability measure (FAAM) scores, pain level, and ability to return to work postoperatively. Criteria for inclusion in our study was the successful collection of survey data. Results: 50 patients were successfully surveyed for long-term postoperative patient-reported outcomes. Patients were surveyed at least 5 years after their original date of surgery with a median time of 6.7 (IQR 1.89) years. Four patients experienced complications including wound complications, sural nerve injury, and reflex sympathetic dystrophy. Four individuals had recurrence of instability with a median of 11.3 months (IQR 8.8) and six patients underwent reoperations. There was significant association of prior ankle instability surgery with PROMIS physical function scores (p=0.013) and being an athlete with PROMIS pain interference scores (p=0.042). Increased age was correlated with lower PROMIS functional scores (p=0.047) and lower FAAM ADL scores (p=0.044). Longer time to survey was significantly associated with an increased FAAM sports score (p=0.048). Longer time to survey was non-significantly associated with increased PROMIS functional scores (p=0.17), decreased PROMIS pain interference scores (p=0.52), and increased FAAM ADL scores (p=0.45). Conclusion: Patient-reported outcomes are important to measure to gain insight into the patient experience following the procedure and may be helpful in preoperative counseling. Our preliminary results suggest that longer time to follow up is associated with more favorable PROMIS domain and FAAM scores. We intend to conduct more surveys to add more power to our study.
Patient Reported Outcomes Following Hindfoot Fusion Utilizing the Triple Arthrodesis Procedure
Authors: Shah Ashish , Young Sean M. , Littlefield Zachary , Luque-Sanchez Kevin S. , Prahad Srihari R. , Young Matthew , Elphingstone Joseph 
Published: November 2022

Category: Hindfoot; Ankle Arthritis Introduction/Purpose: Fusions are used as a salvage procedure to improve stability and return patient to regular functions of daily activities. Triple Arthrodesis is a fusion of three joints, talonavicular, subtalar, calcaneocuboid. There is limited literature on the patient-reported long-term outcomes for this procedure. The aim of this study is to quantify the patient-reported outcomes for the Triple Arthrodesis procedure. Methods: A retrospective analysis was conducted for patients that underwent Triple Arthrodesis at our facility from 2014-2021. Using the electronic medical record (EMR), basic patient demographics, time since surgery, presence of osteoarthritis or rheumatoid arthritis, development of infection, nonunion, hardware failure, and history of previous foot and ankle procedures were all noted. Additionally, we recorded the hardware used during the operation and whether concomitant procedures were performed during the time of surgery. To evaluate outcomes, we used the Patient Reported Outcomes Measurement Information System (PROMIS) survey and Foot Function Index (FFI) scores. Results: A total of 132 patients were included in this study with 50 participants completing the PROMIS and FFI surveys. The average time point at which the outcomes were collected was 5.50 years postoperatively. Postoperative PROMIS scores for physical function, pain interference, and depression were all within one standard deviation of the reference population. The average PROMIS physical function was 38.35, pain interference was 61.52, and depression was 49.82 for this population. The mean FFI scores were 58.56 for pain, 60.06 for disability, 48.06 for activity limitation. There was a significant decrease in postoperative pain scores when compared to preoperative pain of 5.4 to 2.55 (p=0.023). Four patients experienced wound infection, four patients experienced nonunion, six patients required revisional surgery, and three patients experienced hardware failure. Conclusion: Preliminary results Triple Arthrodesis may be beneficial in decreasing pain and lead variable long-term patient satisfaction. We plan to include further statistical analysis comparing the various types of fixation techniques used and the resultant PROMIS and FFI scores. Additionally, we are currently continuing patient calls to collect more completed PROMIS and FFI reports.
Surgical Fixation of Maisonneuve Fractures with a Screw Suture Fixation Device: Results of 10 Cases
Authors: Swords Michael P. , Schepers Tim , Tomlinson Matthew P. , Shank John R. 
Published: November 2022

Category: Trauma; Ankle; Sports Introduction/Purpose: Maisonneuve fractures consist of a fracture of the fibula in the proximal third with associated syndesmotic injury. Surgical management generally involves restoration of fibula length, reduction of the syndesmosis, and stabilization of the syndesmosis. Flexible fixation devices have gained popularity for syndesmotic fixation over the last several years. Current flexible fixation devices are not reliable for fixation of length unstable patterns of injury, like the Maisonneuve fracture. The purpose of the study was to evaluate the results of a new screw- suture syndesmotic device providing aperture fixation of the syndesmosis for fixation of Maisonneuve fractures. Methods: 10 consecutive patients with Maisonneuve injuries were treated with indirect restoration of fibula length, open reduction of the syndesmosis, and stabilization of the syndesmosis with the screw suture device. Talocrural angle and medial clear space was measured and recorded at time of injury, post operatively and 6 months. Rate of hardware removal was recorded.***2 patients are 2 months short of 6 months. both have healed their proximal fibula fractures so no changes to data are anticipated *** Results: There were 5 males and 5 females. 5 patients slipped on ice, 4 patients fell on uneven walking surfaces, 1 patient was in a motorcycle accident. 2 patients had associated posterior malleolus fractures, 1 was fixed with a posterior plate. 1 patient had a medial malleolus fracture repaired with 2 screws. 9 devices were placed independently. 1 device was inserted through a 4 hole 1/3 tubular plate. Average time to surgery was 12.3 days (range 5-24 days). Talocrural angles averaged 8.92 (4.8-14.5mm) on injury films, 13.8mm (10.6-17mm) post operatively and 13.5mm (10.6-16.6) at 6 months. Medial clear space measurement averaged 5.68mm (2-10mm) on injury films, 2.06mm (1.9-2.3mm) post operatively and 2.1mm (2-2.3mm) at 6 months. No devices required removal during the study period. Conclusion: The screw-suture device provided length stable fixation for treatment of Maisonneuve fracture patterns.
Osteotomies Around the Knee Interfere with Alignment of the Hindfoot: A Systematic Review of Biomechanical and Clinical Studies
Authors: Van Oevelen Aline C. , Burssens Arne , Krahenbuhl Nicola , Barg Alexej , Audenaert Emmanuel , Hintermann Beat , Victor Jan M. 
Published: November 2022

Category: Hindfoot; Ankle Introduction/Purpose: Several emerging reports suggest an important involvement of the hindfoot alignment in the outcome of knee osteotomy. At present these studies are scattered across the literature and lack a comprehensive overview. Therefore, we aimed to systematically review all biomechanical and clinical studies investigating the role of the hindfoot alignment in the setting of osteotomies around the knee. Methods: A systematic literature search was conducted on following databases: Pubmed, EMBASE, Cochrane Library and Web of Science. Search terms consisted of 'knee osteotomy' combined with 'hindfoot/ankle alignment'. Inclusion criteria were all English language studies analyzing the association between knee osteotomy and hindfoot alignment comprising biomechanical or clinical outcomes. Exclusion criteria consisted of knee osteotomy performed in conjunction with total knee arthroplasty and level V studies. A quality assessment was conducted using the Quality Appraisal for Cadaveric Studies (QUACS) - and modified methodologic index for non-randomized studies (MINORS) scales. This protocol was performed according to the PRISMA guidelines and registered on PROSPERO (CRD42021277189). Results: Eighteen studies were confirmed eligible and consisted of a cadaveric (n=3) -, retrospective cohort (n=14) - and case- control (n=2) study design. Following knee osteotomy, biomechanical hindfoot characteristics were also positively affected (n=4), except in rigid subtalar joint (n=1) or talar tilt (n=1) deformity. Patient symptoms and/or radiographic alignment (Fig. 1a) at the level of the hindfoot did also improve after knee osteotomy (n=13). However this did not apply in case of a small pre-operative lateral distal tibia- and hip knee ankle (HKA) angulation (Fig. 1b) or in case of a large HKA correction (>14.5°). Additionally, a pre- existent hindfoot deformity (>15.9°) was associated with undercorrection of lower limb alignment following knee osteotomy. The mean QUACS score was 61.3% (range: 46-69%) and mean MINORS score was 9.2 out of 16 (range 6-12) for non-comparative and 16.5 out of 24 (range 15-18) for comparative studies. Conclusion: Osteotomies performed to correct knee deformity have also an impact on biomechanical and clinical outcomes of the hindfoot. In general, these are reported to be beneficial, but several parameters were identified that are associated with newly onset - or deterioration of hindfoot symptoms following knee osteotomy. These results should be interpreted in light of the moderate methodological quality of the included studies. Therefore, further prospective studies are warranted to assess how diagnostic and therapeutic algorithms based on the identified criteria could be implemented to optimize the overall outcome of knee osteotomy in relation to the foot and ankle.
Validation of the Foot and Ankle Outcome Score (FAOS) for Ankle Osteochondral Lesions
Authors: Walls Raymond J. , Azam Mohammad T. , Ellis Scott J. , Kennedy John G. 
Published: November 2022

Category: Sports; Ankle Introduction/Purpose: Subjective patient-reported outcome scores are routinely used to evaluate the efficacy of surgical interventions however to date none have been validated for ankle osteochondral lesions (OCL's). The foot and ankle outcome score (FAOS) is a 42 item subjective questionnaire consisting of 5 domains: pain, symptoms, function in daily activities, function in sports, and quality of life. It has been recently validated for flatfoot deformity and hallux valgus correction. The aim of this study was to validate the FAOS for ankle OCL's. Methods: Patients diagnosed with ankle OCL's from 2008 to 2013 were identified through the hospital foot and ankle registry. A retrospective analysis was performed to determine construct validity, where the FAOS subscales were compared with corresponding short form-12 (SF-12) subscales. Correlation was deemed moderate if the Spearman's correlation coefficient was .4 to .7. Preoperative and postoperative scores of 54 patients with OCL's were compared to determine responsiveness. Content validity was prospectively assessed in 20 patients by a separate questionnaire where patients rated the relevance of each FAOS question to their ankle OCL. A score of 2 or more was considered acceptable. Both retrospective analysis and prospective evaluation of 44 patients were used to assess test-retest reliability, which was measured using intraclass correlation coefficients (ICC's). Results: All of the FAOS subscales demonstrated moderate correlation with the physical health component of the SF-12. The FAOS symptoms subscale showed the least correlation, demonstrating the foot-specific nature of the questionnaire. Mental health related domains demonstrated poor correlation. All five FAOS domains are significantly responsive to change in postoperative patients (p<0.01). All domains have acceptable content validity overall, with quality of life (QoL) and function in sports the highest. Test-retest reliability was very good for all domains with ICC's above 0.8. Conclusion: Patient-based assessments have become increasingly important in evaluating treatment effectiveness. This study has shown that the FAOS has very good construct and content validity, reliability, and responsiveness in patients with ankle OCL's. We support its use and consider it a useful patient-based instrument for the assessment of surgical intervention
Outcomes in Ankle Fracture Surgery: A Systematic Review and Meta-Analysis of Fibular Intramedullary Nail Fixation vs Open Reduction and Internal Fixation in Randomized Controlled Trials
Authors: Walsh John P. , Hsiao Mark S. , LeCavalier Daniel , McDermott Ryland , Gupta Shivali , Watson Troy S. 
Published: November 2022

Category: Trauma; Ankle; Ankle Arthritis; Diabetes Introduction/Purpose: What level I evidence exists to support the use of FNF for surgical management of ankle fractures in high risk patients? The purpose of this study was to compare clinical outcomes following fibular intramedullary nail fixation (FNF) and open reduction and internal fixation (ORIF) of ankle fractures. Methods: A systematic review of the current literature was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Certainty of evidence reported according to GRADE (Grading of Recommendations Assessment, Development, and Evaluation). Our primary hypothesis was that patients undergoing FNF procedures to manage an ankle fracture would have significantly higher patient reported outcome scores (PROs) than patients undergoing ORIF. Primary study outcome measures were validated PROs. Secondary outcome measures included complication rate, secondary surgery rate, and bony union. Results: The primary outcome analysis revealed no evidence of a significant effect difference on Olerud and Molander Ankle Score (OMAS) PRO and no evidence of statistical heterogeneity. Secondary outcome analysis revealed a significant 0.30 (0.12-0.74 95CI) relative risk reduction for complications in FNF (P=0.008). No evidence of an effect difference for bony union. No evidence of reporting bias was appreciated. Sensitivity analyses did not significantly alter effect estimates. Conclusion: The quality of evidence is reasonably strong and likely sufficient to conclude: (1) there is likely no clinically important difference between FNF and ORIF up to 12 months post-operatively, as defined by OMS (moderate certainty); (2) surgeons may reasonably expect reduced complications in 14 out of every 100 patients treated with FNF (moderate certainty); (3) there is likely no difference in bony union (low certainty). Future studies should investigate more patient-centered outcomes and if short-term findings are durable over time if these findings apply to lower risk populations.
Development of a novel defined minimal medium for Gluconobacter oxydans 621H by systematic investigation of metabolic demands
Authors: Battling Svenja , Pastoors Johannes , Deitert Alexander , Götzen Tobias , Hartmann Lukas , Schröder Eliot , Yordanov Stanislav , Büchs Jochen 
Published: November 2022

Abstract
Background
Historically, complex media are used for the cultivation of Gluconobacter oxydans in industry and research. Using complex media has different drawbacks like higher costs for downstream processing and significant variations in fermentation performances. Synthetic media can overcome those drawbacks, lead to reproducible fermentation performances. However, the development of a synthetic medium is time and labour consuming. Detailed knowledge about auxotrophies and metabolic requirements of G. oxydans is necessary. In this work, we use a systematic approach applying the in-house developed μRAMOS technology to identify auxotrophies and develop a defined minimal medium for cultivation of G. oxydans fdh, improving the production process of the natural sweetener 5-ketofructose.

Results
A rich, defined synthetic medium, consisting of 48 components, including vitamins, amino acids and trace elements, was used as a basis for medium development. In a comprehensive series of experiments, component groups and single media components were individually omitted from or supplemented to the medium and analysed regarding their performance. Main components like salts and trace elements were necessary for the growth of G. oxydans fdh, whereas nucleotides were shown to be non-essential. Moreover, results indicated that the amino acids isoleucine, glutamate and glycine and the vitamins nicotinic acid, pantothenic acid and p-aminobenzoic acid are necessary for the growth of G. oxydans fdh. The glutamate concentration was increased three-fold, functioning as a precursor for amino acid synthesis. Finally, a defined minimal medium called ‘Gluconobacter minimal medium’ was developed. The performance of this medium was tested in comparison with commonly used media for Gluconobacter. Similar/competitive results regarding cultivation time, yield and productivity were obtained. Moreover, the application of the medium in a fed-batch fermentation process was successfully demonstrated.

Conclusion
The systematic investigation of a wide range of media components allowed the successful development of the Gluconobacter minimal medium. This chemically defined medium contains only 14 ingredients, customised for the cultivation of G. oxydans fdh and 5-ketofructose production. This enables a more straightforward process development regarding upstream and downstream processing. Moreover, metabolic demands of G. oxydans were identified, which further can be used in media or strain development for different processes.
Bibliometric analysis of fourth industrial revolution applied to heritage studies based on web of science and scopus databases from 2016 to 2021
Authors: Alviz-Meza Anibal , Vásquez-Coronado Manuel H. , Delgado-Caramutti Jorge G. , Blanco-Victorio Daniel J. 
Published: November 2022

Abstract
Using past material and spiritual remains, cultural heritage examines communities’ identity formation across time. Cultural heritage requires public and private institutions to care about its restoration, maintenance, conservation, and promotion. Through a bibliometric perspective, this study has analyzed, quantified, and mapped the scientific production of the fourth industrial revolution applied to heritage studies from 2016 to 2021 in the Scopus and Web of Science databases. Biblioshiny software from RStudio was employed to categorize and evaluate the contribution of authors, countries, institutions, and journals. In addition, VOSviewer was used to visualize their collaboration networks. As a main result, we found that augmented reality and remote sensing represent the research hotspot concerning heritage studies. Those techniques have become common in archaeology, as well as museums, leading to an increase in their activity. Perhaps, more recent tools, such as machine learning and deep learning, will provide future pathways in cultural heritage from data collected in social networks. This bibliometric analysis, therefore, provides an updated perspective of the implementations of technologies from industry 4.0 in heritage science as a possible guideline for future worldwide research.
On the development of an information system for monitoring user opinion and its role for the public
Authors: Karyukin Vladislav , Mutanov Galimkair , Mamykova Zhanl , Nassimova Gulnar , Torekul Saule , Sundetova Zhanerke , Negri Matteo 
Published: November 2022

AbstractSocial media services and analytics platforms are rapidly growing. A large number of various events happen mostly every day, and the role of social media monitoring tools is also increasing. Social networks are widely used for managing and promoting brands and different services. Thus, most popular social analytics platforms aim for business purposes while monitoring various social, economic, and political problems remains underrepresented and not covered by thorough research. Moreover, most of them focus on resource-rich languages such as the English language, whereas texts and comments in other low-resource languages, such as the Russian and Kazakh languages in social media, are not represented well enough. So, this work is devoted to developing and applying the information system called the OMSystem for analyzing users’ opinions on news portals, blogs, and social networks in Kazakhstan. The system uses sentiment dictionaries of the Russian and Kazakh languages and machine learning algorithms to determine the sentiment of social media texts. The whole structure and functionalities of the system are also presented. The experimental part is devoted to building machine learning models for sentiment analysis on the Russian and Kazakh datasets. Then the performance of the models is evaluated with accuracy, precision, recall, and F1-score metrics. The models with the highest scores are selected for implementation in the OMSystem. Then the OMSystem’s social analytics module is used to thoroughly analyze the healthcare, political and social aspects of the most relevant topics connected with the vaccination against the coronavirus disease. The analysis allowed us to discover the public social mood in the cities of Almaty and Nur-Sultan and other large regional cities of Kazakhstan. The system’s study included two extensive periods: 10-01-2021 to 30-05-2021 and 01-07-2021 to 12-08-2021. In the obtained results, people’s moods and attitudes to the Government’s policies and actions were studied by such social network indicators as the level of topic discussion activity in society, the level of interest in the topic in society, and the mood level of society. These indicators calculated by the OMSystem allowed careful identification of alarming factors of the public (negative attitude to the government regulations, vaccination policies, trust in vaccination, etc.) and assessment of the social mood.