bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer
Authors: Pradat Yoann , Viot Julien , Gunbin Konstantin , Yurchenko Andrey , Cerbone Luigi , Deloger Marc , Grisay Guillaume , Verlingue Loic , Scott Véronique , Padioleau Ismael , Panunzi Leonardo , Michiels Stefan , Hollebecque Antoine , Jules-Clément Gérôme , Mezquita Laura , Lainé Antoine , Loriot Yohann , Besse Benjamin , Friboulet Luc , André Fabrice , Cournède Paul-Henry , Gautheret Daniel , Nikolaev Sergey 
Published: November 2022

AbstractMetastatic relapse after treatment is the leading cause of cancer mortality, and known resistance mechanisms are missing for most treatments administered to patients. To bridge this gap, we analyze a pan-cancer cohort (META-PRISM) of 1,031 refractory metastatic tumors profiled via whole-exome and transcriptome sequencing. META-PRISM tumors, particularly prostate, bladder, and pancreatic types, displayed the most transformed genomes compared to primary untreated tumors. Standard-of-care resistance biomarkers were identified only in lung and colon cancers - 9.3% of META-PRISM tumors, indicating that too few resistance mechanisms have received clinical validation. In contrast, we verified the enrichment of multiple investigational and hypothetical resistance mechanisms in treated compared to non-treated patients, thereby confirming their putative role in treatment resistance. Additionally, we demonstrated that molecular markers improve six-month survival prediction, particularly in patients with advanced breast cancer. Our analysis establishes the utility of the META-PRISM cohort for investigating resistance mechanisms and performing predictive analyses in cancer.Statement of significanceThis study highlights the paucity of standard-of-care markers that explain treatment resistances and the promises of investigational and hypothetical markers awaiting further validation. It also demonstrates the utility of molecular profiling in advanced-stage cancers, particularly breast cancer, to improve the survival prediction and assess eligibility to phase I clinical trial.
Time to negative throat culture following initiation of antibiotics for pharyngeal group AStreptococcus: a systematic review and meta-analysis to inform public health control measures
Authors: McGuire Emma , Li Ang , Collin Simon M , Decraene Valerie , Cook Michael , Padfield Simon , Sriskandan Shiranee , Van Beneden Chris , Lamagni Theresa , Brown Colin S 
Published: November 2022

ABSTRACTBackgroundPublic health guidance recommending isolation of individuals with group A streptococcal (GAS) infection or carriage for 12-24 hours from antibiotic initiation to prevent onward transmission requires a strong evidence-base.MethodsWe conducted a systematic review (PROSPERO CRD42021290364) and meta-analysis to estimate the pooled proportion of individuals who remain GAS culture-positive at set intervals after initiation of antibiotics. We searched Ovid MEDLINE (1946-), EMBASE (1974-) and the Cochrane library. We included interventional or observational studies with ten or more participants reporting rates of GAS throat culture during antibiotics for culture confirmed GAS pharyngitis, scarlet fever, and asymptomatic pharyngeal GAS carriage. We did not apply age, language, or geographical restrictions.FindingsOf 5,058 unique records identified, 43 were included; 37 (86%) randomised controlled studies, three (7%) non-randomised controlled trials and three (7%) before-and-after studies. The proportion of individuals who remained culture-positive at day 1, day 2, and day 3-9 were 6.9% (95% CI 2.7-16.8%), 5.4% (95% CI 2.1-13.3%) and 2.6% (95% CI 1.6-4.2%). For penicillins and cephalosporins, day 1 positivity was 6.5% (95% CI 2.5-16.1%) and 1.6% (95% CI 0.04-42.9%) respectively. Overall, for 9.1% (95% CI 7.3-11.3), throat swabs collected after completion of therapy were GAS culture-positive.InterpretationOur review provides evidence that antibiotics for pharyngeal GAS achieve a high rate of culture conversion within 24 hours but highlights the need for further research given the methodological limitations of published studies and imprecision of pooled estimates. Further evidence is needed for non-beta-lactam antibiotics and for asymptomatic individuals.
Molecular basis of ligand-dependent Nurr1-RXRα activation
Authors: Yu Xiaoyu , Shang Jinsai , Kojetin Douglas J. 
Published: November 2022

ABSTRACTSmall molecule compounds that activate transcription of Nurr1-RXRα (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechanisms. Here, we show that RXRα ligands activate Nurr1-RXRα through a mechanism that involves ligand-binding domain (LBD) heterodimer proteinprotein interaction (PPI) inhibition, a paradigm distinct from classical pharmacological mechanisms of ligand-dependent nuclear receptor modulation. NMR spectroscopy, protein-protein interaction, cellular transcription assays show that Nurr1-RXRα transcriptional activation by RXRα ligands is not correlated with classical RXRα agonism but instead correlated with weakening Nurr1-RXRα LBD heterodimer affinity and heterodimer dissociation. Our data inform a model by which pharmacologically distinct RXRα ligands (agonists and Nurr1-RXRα selective agonists that function as RXRα antagonists) operate as allosteric PPI inhibitors that release a transcriptionally active Nurr1 monomer from a repressive Nurr1-RXRα heterodimeric complex. These findings provide a molecular blueprint for ligand activation of Nurr1 transcription via small molecule targeting of Nurr1-RXRα.
An industrial heterogeneous data based quality management KPI visualization system for product quality control
Authors: Zhao Ruihan , Luo Liang , Li Pengzhong , Wang Jinguang 
Published: November 2022

Purpose
Quality management systems are commonly applied to meet the increasingly stringent requirements for product quality in discrete manufacturing industries. However, traditional experience-driven quality management methods are incapable of handling heterogeneous data from multiple sources, leading to information islands. This study aims to present a quality management key performance indicator visualization (QM-KPIVIS) system to enable integrated quality control and ultimately ensure product quality.

Design/methodology/approach
Based on multiple heterogeneous data, an integrated approach is proposed to quantify explicitly the relationship between Internet of Things data and product quality. Specifically, this study identifies the tracing path of quality problems based on multiple heterogeneous quality information tree. In addition, a hierarchical analysis approach is adopted to calculate the key performance indicators of quality influencing factors in the quality control process.

Findings
Proposed QM-KPIVIS system consists of data visualization, quality problem processing, quality optimization and user rights management modules, which perform in a well-coordinated manner. An empirical study was also conducted to validate the effectiveness of proposed system.

Originality/value
To the best of the authors’ knowledge, this study is the first attempt to use industrial Internet of Things and multisource heterogeneous data for integrated product quality management. Proposed approach is more user-friendly and intuitive compared to traditional empirically driven quality management methods and has been initially applied in the manufacturing industry.
Tolerance analysis of planar parts with skin modeling considering spatial distribution characteristics of surface morphology and local surface deformations
Authors: Shen Tuan-Hui , Lu Cong 
Published: November 2022

Purpose
This paper aims to develop a method to improve the accuracy of tolerance analysis considering the spatial distribution characteristics of part surface morphology (SDCPSM) and local surface deformations (LSD) of planar mating surfaces during the assembly process.

Design/methodology/approach
First, this paper proposes a skin modeling method considering SDCPSM based on Non-Gaussian random field. Second, based on the skin model shapes, an improved boundary element method is adopted to solve LSD of nonideal planar mating surfaces, and the progressive contact method is adopted to obtain relative positioning deviation of mating surfaces. Finally, the case study is given to verify the proposed approach.

Findings
Through the case study, the results show that different SDCPSM have different influences on tolerance analysis, and LSD have nonnegligible and different influence on tolerance analysis considering different SDCPSM. In addition, the LSD have a greater influence on translational deviation along the z-axis than rotational deviation around the x- and y-axes.

Originality/value
The surface morphology with different spatial distribution characteristics leads to different contact behavior of planar mating surfaces, especially when considering the LSD of mating surfaces during the assembly process, which will have further influence on tolerance analysis. To address the above problem, this paper proposes a tolerance analysis method with skin modeling considering SDCPSM and LSD of mating surfaces, which can help to improve the accuracy of tolerance analysis.
Influence of cultural background on tourist flow process and outcomes: an empirical study with Chinese-speaking tourists in Japan
Authors: Pang Yunian , Li Yanghepu , Zhao Liang 
Published: November 2022

Purpose
This paper aims to fill a research gap on whether cultural background (Eastern or Western) influences tourist flow experiences and outcomes with Chinese-speaking tourists.

Design/methodology/approach
The authors conducted flow-aware, guided cultural tours in Kyoto, Japan, from March 2019 to February 2020. Tourists visited the same spots on the same route with the same guide to avoid discrepancies stemming from experiencing different tours with different guides. Professional photoshoots were conducted to study the flow experience under high challenges. Participants were Chinese-speaking tourists worldwide. The guide spoke in Chinese to minimise language bias. Participants were asked to complete an anonymous questionnaire within one week of the tours.

Findings
The authors received 191 valid responses. Those from the Eastern regions showed significantly lower flow states and outcomes than their counterparts from the Western regions under high challenges, whereas this phenomenon was not observed under low challenges. A positive correlation between the flow state and outcomes was observed in both regional groups.

Originality/value
To the best of the authors’ knowledge, this is the first study to apply flow theory to guided cultural tours with Chinese-speaking tourists from different cultural backgrounds. It was found that those from the Eastern regions can have flow experience and good outcomes in guided tours, although they may require a lower level of challenge. A managerial implication is that cultural tours should be designed considering the balance between challenges and tourists’ cultural background to optimise their flow experiences and outcomes.
The role of community radio in information dissemination towards youth development in Ghana
Authors: Kankam Philip Kwaku , Attuh Stephen 
Published: November 2022

Purpose
Community radio attempts to place the power of communication in the hands of community members, particularly the youth, so that they can create and broadcast materials that address local community issues. The purpose of the study is therefore to look into the potential impacts of community radio and the function it plays in youth development.

Design/methodology/approach
This study employed a qualitative research approach to investigate the role of community radio in information dissemination towards youth development in Ghana. Two community radio stations were selected for the study, and through the use of semi-structured interview, qualitative data were collected from 42 participants comprising two programme managers, four radio producers and 36 youth. The qualitative research approach enabled in-depth understanding of the phenomenon of the study.

Findings
This study found that both community radio stations aired youth-centred programmes that were beneficial to the development of the youth within the stations’ coverage communities. The results further reveal that community radio offers the opportunity and platform for the youth to engage the political authorities for development and also entertain themselves.

Originality/value
The authors consider this study original both in conceptualization and design. The main question being interrogated stems from identified gaps in the literature, and this study intends to fill these knowledge gaps. This study’s originality also stems from the fact that there is a paucity of information on the subject of study in the context of Ghana.
Gender representation on the editorial boards of Library and Information Science journals
Authors: Parabhoi Lambodara , Verma Manoj Kumar , Dewey Rebecca Susan 
Published: November 2022

Purpose
This paper aims to determine the gender composition of journal editorial boards in the field of library and information science and to identify trends in the gender composition of different editorial roles and the country of affiliation and occupation of people fulfilling these roles.

Design/methodology/approach
In an analysis of 13 selected Library Information Science journals published by the Emerald Publishing group, data relating to 549 editors and editorial board members were obtained from the Open Editors online database. Data were assessed by role, gender, country and continent of their affiliation, and occupation.

Findings
Women were found to be under-represented as editors and editorial board members in 10 of the 13 journals. This was most evident in the highest-ranking role of editor or editor-in-chief. The majority of editors and editorial board members were from English-speaking countries located in Europe and the Americas, followed by Asia. The vast majority of editorial personnel belonged to the teaching and learning profession, with relatively few support staff, or researchers taking on these roles.

Originality/value
The findings of this study highlight the gender inequality in prestigious and career-advancing academic roles across multiple research areas. To the best of the authors’ knowledge, no such research has yet been conducted in the field of library and information science.
Are people the greatest asset: talent management in SME hotels in Nigeria during the COVID-19 crisis
Authors: Howe-Walsh Liza , Kirk Susan , Oruh Emeka 
Published: November 2022

Purpose
This paper aims to evaluate the approaches to talent management (TM) in small- to medium-sized enterprise (SME) hotels in Nigeria during the COVID-19 crisis drawing on the resource-based view (RBV) of Strategy.

Design/methodology/approach
An interpretivist methodology was adopted, and 42 semi-structured interviews were undertaken with SME hotel owners, self-initiated expatriate (SIE) talent and local workers in Nigerian hotels. A thematic approach to analysis was undertaken to identify key themes.

Findings
The findings highlight how SME hotel owners’ reactive and short-term approaches to TM have created problems during the pandemic as they are unable to rely on acquiring SIE talent to fill key skills gaps. Furthermore, failure to capitalise on the expertise and networks of their current SIEs has resulted in a lack of knowledge sharing with other local employees. This results in TM strategies that do not offer differentiated approaches that balance talent flows to achieve competitive advantage.

Practical implications
SME hotel leaders should adopt a more equitable approach to TM that values all workers rather than exclusively focusing on SIEs. Employment contracts should ensure that SIEs are responsible for training and developing local workers as part of a networking approach to RBV.

Originality/value
This novel study focused on TM within SME hotels in a Nigerian context during COVID-19. The findings show how SME senior leaders value SIE talent above local workers and pursue a TM strategy that perpetuates the status quo. The COVID-19 crisis has acted as a catalyst for leaders to recognise the value of local talent and consider a more sustainable approach to TM.
Dynamic capabilities for digital procurement transformation: a systematic literature review
Authors: Herold Silke , Heller Jonas , Rozemeijer Frank , Mahr Dominik 
Published: November 2022

PurposeThe purpose of this paper is to achieve a collective understanding of the capabilities required for digital procurement transformation (DPT).Design/methodology/approachThe authors contextualize theory about dynamic capabilities (DCs) to integrate the fragmented body of literature on procurement digitalization by means of a systematic literature review (SLR). By extracting and clustering capabilities, as well as proven performance outcomes from existing literature in the field, the authors develop a conceptual model of the DCs required for DPT.FindingsThe authors first introduce and define DPT and the corresponding motivations that trigger firms to invest in advanced digital technologies. Second, by adopting the DC lens, the authors provide an overview of nine microfoundations required for DPT and highlight the strategic options procurement leaders can use when strategizing about adopting combinations of digital technologies. Third, the authors present a future research agenda on DCs for DPT.Research limitations/implicationsThe developed conceptual model must be verified and enhanced through further empirical research.Practical implicationsThe conceptual model can be used by procurement leaders as a starting point and framework when strategizing about digitally transforming the procurement organization.Originality/valueThe study is the first to synthesize previous research findings on procurement digitalization through an SLR in order to develop a fine-grained conceptual model that supports practitioners and researchers alike in better understanding the capabilities required for and potential performance outcomes of DPT.
Brazilian federal universities and their sustainable practices based on sustainable logistics management plan
Authors: Moura-Leite Rosamaria Cox , Lopes José Carlos de Jesus , Yamazaki Carolina 
Published: November 2022

Purpose
This study aims to analyze the situation of Federal Universities (FUs) regarding compliance with the Sustainable Logistics Management Plan (PLS) Normative Instruction (NI) 10/2012, the adoption of which is compulsory for all agencies and entities of direct, autarchic and foundational public administration and dependent state-owned enterprises, including FUs. PLS is an instrument intended to establish sustainability practices in the management of public organizations.

Design/methodology/approach
The data were collected through searches on the websites of the 68 Brazilian FUs that constitute the study population, along with their plans of action (PAs) and monitoring reports.

Findings
The collected data revealed that only 25% of the FUs had a current PA and 15% published a report for the years 2020 or 2021. Furthermore, the most commonly found mandatory issue to be addressed in PAs was electricity, and the least frequent was sustainable procurement and contracting.

Research limitations/implications
Future research should be conducted with the Management Committee of the PLS to understand the reason for the discontinuity of this work in some universities and the rationale behind the mandatory issues.

Originality/value
Some studies address FUs’ implementation of PLS, which promotes sustainable management systems. However, each of the identified studies investigated only one of the seven mandatory issues set down in NI 10/2012, which did not allow a complete assessment of the FUs’ situation exclusively in respect of compliance with the PLS.
The impact of financial management practices on accountability of Islamic social enterprise (ISE)
Authors: Kamaruddin Muhammad Iqmal Hisham , Auzair Sofiah Md. 
Published: November 2022

Purpose
This study aims to examine the role of financial management practices, which consist of financial disclosure, internal control, financial planning and budgeting and financial performance on Islamic social enterprises’ (ISEs) accountability.

Design/methodology/approach
Questionnaires were administered to financial officers of 102 Malaysian ISEs. Findings were analysed using Smart-PLS to examine the relationships between financial management practices and accountability.

Findings
Results of this study indicate a direct relationship exists between internal control and accountability. Relationships between other financial management practices and accountability are indirect through internal control. Hence, the data demonstrates that internal control has a mediating role on other financial management practices, which are financial disclosure and financial performance management with the accountability of ISEs.

Research limitations/implications
This study has implicated the significant role of financial management practices in ISEs in the pursuance of their accountability especially internal control to achieve public trust.

Practical implications
Appropriate financial management practices, especially internal control, are essential for the ISEs to achieve good accountability.

Originality/value
This study contributes to the field of management and social accounting by providing empirical evidence on ISE practices specifically on financial management practices and accountability. This framework thus presents among the early attempts in studying accountability issues in ISEs.
Reevaluating the mission of control in records management: tools for a staff-centered approach
Authors: Chandler Kate 
Published: November 2022

Purpose
The purpose of this paper is to suggest that a user-centered approach to records management may result in more sustainable, intuitive and defensible records management programs compared to alternatives.

Design/methodology/approach
A two-part methodology is adopted: part one explores the literature for records management programs that impose a high degree of control over records at cost to users, and part two explores the author’s experience of developing tools that facilitate a user-centred approach.

Findings
To adopt a user-centred approach to records management requires reassessing the degree of control that should be imposed over records.

Originality/value
This paper provides an original analysis of the field of records management through the lens of usability, as well as original solutions in the form of technology that supports usability.