bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty Acid Metabolism-related Genes in Bronchoalveolar Lavage Fluid Unveil Prognostic and Immune Infiltration in Idiopathic Pulmonary Fibrosis
Authors: Lyu Yin , Guo Chen , Zhang Hao 
Published: June 2022

Abstract
Background: Idiopathic pulmonary fibrosis, often abbreviated as IPF, is a condition that is both chronic and progressive, and has an unfavorable prognosis. Recent research has demonstrated that individuals with IPF exhibit characteristic alterations in the fatty acid metabolism in their lungs, suggesting an association with the disease pathogenesis. Here, we explored whether the gene signature associated with fatty acid metabolism might be used as a reliable biological marker for predicting the IPF patients' survival.Methods: Data of fatty acid metabolism-related genes (FAMRGs) were extracted from the Kyoto Encyclopedia of Genes and Genomes (KEGG), Hallmark, and Reactome databases. The GSE70866 data set was retrieved for information on individuals diagnosed with IPF. Next, a consensus clustering approach was used to discover novel molecular subgroups. Then, Gene Set Enrichment Analysis (GSEA) was conducted to evaluate the mechanisms involved. CIBERSORT was utilized to ascertain the infiltration levels of immune cells in the identified subgroups premised on specific gene expression signatures of immune cells. Finally, the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm and multivariate Cox regression analysis were utilized in the development of a prognostic risk model.Results: The patterns of gene expression that are linked to fatty acid metabolism were used to construct two subgroups that had remarkably different prognoses. GSEA indicated that immune-related pathways, were significantly altered between the two subgroups, and different subgroups had different metabolic characteristics. Poor prognosis was associated with high immune cell infiltration, particularly activated NK cells, monocytes, and activated mast cells. A risk model that was developed premised on FAMRGs showed excellent significance for use in predicting IPF. The prognosis for individuals diagnosed with IPF might be correctly predicted using a nomogram that incorporated clinical features and the risk model.Conclusion: The proposed fatty acid metabolism-related gene signature is a potential biological marker for predicting the clinical outcomes and infiltration status of immune cells, and may ultimately increase the accuracy of treating patients with IPF.
Nudged elastic band calculations of the (4H)SiX hydrogarnet type defect in Mg2SiO4 forsterite
Authors: Poe Brent T. , Perna Maria Grazia 
Published: June 2022

Abstract
First-principles calculations based on density functional theory (DFT) using the generalized gradient approximation (GGA) were performed to assess the energetic barriers separating different topological configurations of the (4H)SiX hydrogarnet type defect in Mg2SiO4 forsterite with the climbing image nudged elastic band (CI-NEB) method. Barrier heights are low (&lt;0.6 eV) with respect to typical activation energies observed for H-diffusion but more comparable to those for electrical conductivity of H2O-bearing nominally anhydrous minerals. As can be expected, hydrogen bonding to O atoms both within the defect and belonging to adjacent tetrahedra plays a fundamental role in the stability of each configuration. Saddle points along the minimum energy path (MEP) typically correspond to the transition of one hydrogen bond breaking to form a new hydrogen bond such that one or more OH bonds have shifted in direction without themselves breaking. MEPs show that slightly out-of-plane torsional hopping from one configuration to another can reduce the height of the barrier. We illustrate several different reaction coordinates between symmetry equivalent pairs of configurations and non-symmetry related pairs that can result in an effective means of local charge transport by shifting the center of mass of the (4H)4+ cluster within the defect site without proton transfer to an interstitial site. Especially at low temperatures in the absence of thermally activated processes that result in the breaking of stronger chemical bonds, these types of configurational transformation mechanisms are likely to be important contributors to the dielectric behavior of nominally anhydrous silicate minerals and also affect both electrical conductivity and electrical conductivity anisotropy when investigated by AC methods such as impedance spectroscopy. The NEB method can also be used to examine more effective charge and mass transport processes that involve the dissociation of the hydrogarnet defect into more complex chemical species, which might involve similar hydrogen bond breaking and forming processes observed in this study along with more significant atomic displacements.
Background field method and generalized field redefinitions in effective field theories
Authors: Quadri Andrea 
Published: June 2022

We study the non-linear background field redefinitions arising at the
quantum level in a spontaneously broken effective gauge field theory.
The non-linear field redefinitions are crucial for the symmetric
(i.e. fulfilling all the relevant functional identities of the theory)
renormalization of gauge-invariant operators. In a general
R_\xiRξ-gauge
the classical background-quantum splitting is also non-linearly deformed
by radiative corrections. In the Landau gauge these deformations vanish
to all orders in the loop expansion.
La Unión Europea y la construcción de la agenda de género africana en el marco de la Cooperación Internacional al Desarrollo
Authors: Morasso Carla 
Published: June 2022

La igualdad de género ocupa actualmente un lugar central en las estrategias de Ayuda Oficial al Desarrollo. Los oferentes de cooperación internacional consideran que disminuir la brecha de género es un factor clave para el desarrollo sostenible. Entre ellos se distingue la Unión Europea, la cual, a partir de su rol de normative power, se constituyó como un actor central en el impulso de las agendas de género a través de sus relaciones exteriores. Esto puede observarse en el caso de África, un socio privilegiado europeo donde se han desplegado numerosos programas y proyectos orientados principalmente a disminuir el gap de género y empoderar económicamente a las mujeres. En este contexto, el artículo aborda el rol que ha tenido la cooperación europea en la difusión de valores y prácticas de género en el continente africano, dando cuenta de las principales iniciativas ejecutadas y brindando algunas reflexiones sobre los resultados alcanzados.
Palabras clave: Género – Unión Europea – África – Poder Normativo – Cooperación Internacional al Desarrollo
Promotion of environmental projects to conform with UWWTD and integrated water management
Authors: Papadopoulou A. , Stefanakou G. , Fougias E. 
Published: June 2022

Abstract
The region of East Attica in Greece faces stress on its water supply, caused mainly by agricultural activities and tourism in the summer. It is therefore imperative for the region to integrate water reuse in its water resources management plan. To this end, a project was conceived that accommodated stakeholder management practices to ensure public acceptance with the challenge to transform potential project risks to opportunities. In particular, two major wastewater projects in the region were approved for co-financing by the European Union (EU) Cohesion funds and implementation by the Athens Water Supply and Sewerage Company (EYDAP S.A.) for agglomerations in East Attica (Rafina/Artemida & Marathon agglomerations). Both projects aim to achieving compliance with 91/271/E.E.C, Urban Wastewater Treatment Directive (UWWTD) and producing treated effluent wastewater that complies with the national standards for unlimited irrigation and urban reuse. Furthermore, another wastewater scheme, co-financed by EU funds with the beneficiary being the Prefecture of Attica, involves the agglomerations of Koropi and Paiania respectively, which are also currently non-compliant. The aforementioned scheme is presently under development after upgrading with advanced tertiary treatment will also produce quantity of reclaimed water suitable for aquifer recharge to restore the water quality of groundwater bodies.
Investigations of velocity and pressure fluctuations over a stepped spillway with new step configuration
Authors: Jahad Udai A. , Al-Ameri Riyadh , Das Subrat 
Published: June 2022

AbstractThe effect of the end sill shape of steps for two-phase flow over stepped spillways was investigated. A quantitative assessment approach has been applied. Experimental and numerical tests were used for stepped spillways with different step configurations. The computational fluid dynamics (CFD) method with a two-dimensional (2D) flow model, including volume of fluid (VOF) and k-ε models was applied to conduct a critical analysis in different flow conditions. Step heights hs were 0.03 m and 0.05 m, and the number of steps Ns were 10 and 6, respectively. The step configurations assessed were Step models, Sill models, and Curve models with angle θ = 26.6°. The developed 2D model investigated the flow patterns, velocity distribution, and pressure for several step configurations. For validation, the correlation coefficient (R), mean absolute percentage error (MAPE), and root mean squared error (RMSE) were tested. The results showed negative pressure at the flat steps at Nappe flow, whilst negative pressure did not appear in the Curve model. MAPE and RMSE were 4.32 and 0.21 respectively, with R =0.996. In the CFD results, velocity and the pressure distributions were compared with the experiments and showed a correlation within a (±6%) tolerance. The Curve models were the best in terms of the flow characteristics.
Knowledge about HIV/AIDS and Attitudes towards Sexuality of Undergraduate Students at a Peruvian University
Authors: Achachagua Anwar Julio Yarin , Encalada Díaz Ivan Ángel , Elias Silupu Jorge Wilmer , Surichaqui Mateo Abad Antonio , Isla Alcoser Sandy Dorian , Surichaqui Tiza Beatriz Silvia 
Published: June 2022

Background:
In Peru, there are some concerning difficulties in ascertaining the situation of sexually transmitted diseases, which makes it even more difficult to prevent and improve this situation.

Objective:
The objective of this article was to inquire what knowledge the students at a Peruvian university have about HIV/AIDS in order to determine the relationship between this knowledge and attitude towards sexuality.

Methods:
This was a cross-sectional study with a non-experimental design, involving a quantitative approach and a correlation measurement. 294 students were included in the study. The data collection technique used was the survey for each study variable with a Cronbach's alpha of .884 for the first variable and .704 for the second variable. Spearman's Rho coefficient correlation test was used to contrast the results.

Results:
Among the results, a significant and reverse correlation was obtained between knowledge about HIV/AIDS and attitudes towards sexuality (r = -.304, p-value = .000). Likewise, only 54.8% of the students were found to have adequate knowledge regarding HIV/AIDS and 75.17% had normal attitude towards sexuality.

Conclusion:
It has been concluded that the more the adequate knowledge about HIV, the less students present risk-taking attitudes towards sexuality, and given the evidence of risky sexual behaviour in all age groups, as well as a significant number engaging in regular risk sexual behaviour, we suggest that universities implement sex education programs permanently regardless of the academic cycle.
A Study On The Management Approaches Adopted By Individuals With Osteoarthritis Knee In Karad
Authors: Minal .B. Masekar  , Dr. Smita Patil  , Dr. Chandrakant Patil  , Dr. Khushboo Chotai  
Published: June 2022

Osteoarthritis (OA) is a degenerative condition of the joints characterised by focal loss of articular cartilage along with sclerosis of subchondral bone and formation of osteophytes. The purpose of this study was to determine the various management approaches adopted by the people suffering from knee osteoarthritis. As this condition affects a large population the methods use to deal with the symptoms differ which are described in this study highlighting the preference of a physiotherapist by the patients. The study was carried out in Krishna Hospital, Karad with the sample size of 60 using purposive sampling method, a cross sectional study was performed using a descriptive study design. Individuals with Osteoarthritis of knee are included based on the inclusion and exclusion criteria. The data collected was analysed qualitatively which resulted in 65% participants who approached General practitioner (GP) as initial approach, with only 6% approaching a physiotherapist. 81% used heat therapy as a measure to manage their symptoms while only 30% used exercises as a modality. The primary finding was that there is no clear pathway for management of Osteoarthritis of knee in Karad. Majority opted for General-Practitioner as their initial approach. Physiotherapists were preferred only by a few, not many were seen utilising exercise modality. Since there is a vast difference in treatments by variety of individuals, this study will thus help in determining the various approaches for knee osteoarthritis and establishing a definitive and effective protocol for the management of the patients symptoms.
Correlative Assessment of Blood Parameters and Periodontal Status in Smokers- A Pilot Project
Authors: Dr Shreya Shetty  , Dr Mawadah  Almehmadi  , Dr Halah Qadah  , Dr Mazen Ismael Zaafrani  , Dr Shrooq Osama Ezzaddin  , Dr Jumanah Khaled Alsaedi  , Khamrunissa Hussain Sheikh  
Published: June 2022

Platelets and leukocytes activated in response to periodontal microorganisms during bacteremia can go on to excite other cells, enhancing the likelihood of atherosclerosis and coronary artery disease. Reports also indicate that decrease in the number of erythrocytes may occur secondary to periodontal disease. Smoking is a known risk factor for periodontal disease by virtue of its adverse effects on the blood cells. It was therefore decided to investigate the relationship between the red blood cel l(RBC), white blood cell (WBC) and platelet counts and periodontal parameters among smokers and non- smokers; to subsequently assess any implication of the systemic effects. Blood counts(RBC, WBC, platelets) for the present study were obtained from peripheral venous blood of 126 patients , both male and female aged between 18-45 years, in each group as follows: GROUP 1 :Periodontally healthy (n = 42) (non-smokers) GROUP 2: Chronic periodontitis (n = 42)( non- smokers) GROUP 3: Chronic periodontitis (n = 42) ( smokers) The clinical parameters to assess periodontitis included plaque index(PI), bleeding index(BI) and Clinical Attachment Loss( CAL) and history of smoking was elicited based on amount, frequency and duration of smoking. ANOVA tests followed by post HOC –Tukey HSD test revealed that there were significant differences between the 3 groups with respect to PI, BI and RBC counts(p<0.05). Pearson correlation test revealed a significant correlation between plaque index and platelet counts in group 1 only(p<0.05). Additionally, a significant correlation was also observed between WBC and platelet counts in all three groups(p<0.05).Variations in blood counts in different periodontal situations may pose a risk of systemic inflammation in smokers and non- smokers.
Methods of determining stocks of commercial fish species and fish products in inland water bodies and estimation of their reliability (case of Kenozero National Park)
Authors: Dvoryankin Gennadiy 
Published: June 2022

More than 95% of fish on the territory of the Kenozero National Park are caught in the Park's two largest lakes - Kenozero and Lekshmozero. There are presented the results of assessing the stocks of commercial fish species and fish products of these two lakes obtained in the course of fisheries monitoring using direct methods of ac-counting for the fish abundance. The data on fish ichthyomass and fish products analyzed by using the indirect methods are also given, the comparative analysis is made. It has been found that the indirect methods applied even for the same water body show
a large spread of the final results varying tenfold in some cases. This is due to the fact that the used in these methods
limited biotic and abiotic characteristics of the water bodies don’t cover all the significant indices that affect the formation of the ichthyomass and fish products in this water body. A conclusion is made about a careful ap-proach to the application of indirect methods for assessing the fishery characteristics of the water body. The research on the effectiveness and reliability of indirect methods is proposed to be continued with involving a larger number of parameters. At present, when preliminary fisheries management assessment of unexplored water bodies of the taiga zone of the northern region
it is recommended to use the zonal index as the most universal one.
Force performance of trawl system – V: predictive modeling
Authors: Nedostup Alexander Alekseevich , Razhev Alexey Olegovich , Nasenkov Pavel , Konovalova Karina 
Published: June 2022

Predictive modeling (PM) of the trawl system (TS) is a complex, interdisciplinary and cognitive representation of the TS links. Predictive modeling of the vehicle predicts its operational parameters in various conditions (transition, etching of warriors, trawling, hauling of trawl and other processes). It is also possible to process the data of experiments and numerical simulations on the basis of PM together, which is not compatible with mathematical and physical simulations. In the process of designing a vehicle, it is often necessary not only mathematical, physical, but also their predictive modeling. By TS is meant the trawl itself (cable-net section) with rigging, cable equipment, trawl boards, warp, connecting elements, fan winch (trawl winch), rope net drum, sensors (travel horizon, trawl bag filling, strains in the cords, the length of the cords, the opening of the mouth of the trawl, etc.). By predictive modeling (hereinafter referred to as PM) we will mean multiscale interdisciplinary processes occurring in the TS. Predictive modeling of the vehicle is one of the important components of the virtual reality of the vehicle operation and an important module of the software and hardware simulator Tral. There is set the task
of predictive modeling of the characteristics of rope-rope products from which rope-net fishing tools of the TS are made. A mathematical model of predictive modeling of structural, geometric and power characteristics of rope-rope products is proposed. Based on the theory of similarity, it is possible to predict the values of the output data with fewer characteristics of rope products. The proposed method allows, without conducting experiments on ropes of large diameter, to determine their basic physical and mechanical properties, those geometric and power characteristics that are necessary for modeling new elements of the vehicle.
Correlation of Mother’s Education Level with College Student Leadership Ability
Authors: Supriyono Agus , Maharani Diandra Shafira , Nengsih Wahyu 
Published: June 2022

Penelitian ini mengkaji hubungan antara kemampuan kepemimpinan mahasiswa dengan tingkat pendidikan ibu. Kepemimpinan merupakan suatu kemampuan atau keterampilan yang harus dimiliki setiap orang. Dimana meliputi kemampuan seseorang untuk mengenali, mengontrol, dan mengatur emosi dan perasaan, baik perasaan sendiri maupun perasaan orang lain. Hal ini diperlukan untuk memecahkan dan menyelesaikan suatu masalah dengan tepat. Penelitian ini bertujuan untuk mengetahui perbedaan jiwa kepemimpinan siswa dilihat dari perbedaan tingkat pendidikan ibu. Penelitian ini menggunakan metode kuantitatif dan analisis deskriptif. Pengumpulan data dan dokumen dilakukan dengan menggunakan kuesioner yang dibagikan kepada mahasiswa dengan jumlah responden sebanyak 76 mahasiswa dari berbagai universitas. Desain penelitian ini adalah penelitian korelasional. Subyek penelitian ini adalah mahasiswa dengan mempertimbangkan tingkat pendidikan ibunya. Hasil penelitian ini menunjukkan hasil yang signifikan dari data yang kami peroleh
Clinical presentation and treatment of lymphoma in companion rats (Rattus norvegicus; 2008–2020)
Authors: Faye-Fierman Sarah , Gardhouse Sara , McCready Julianne E. , Appleby Ryan , Hocker Samuel E. 
Published: June 2022

Abstract

OBJECTIVE
To describe the clinical presentation, treatment, and treatment outcomes for companion rats (Rattus norvegicus) diagnosed with lymphoma.

ANIMALS
All rats that presented to the exotics service and underwent postmortem examination during the time period of 2008 through 2020 were evaluated.

PROCEDURES
The medical records of 35 rats were evaluated for an ante- or postmortem diagnosis of lymphoma. Cases with a diagnosis of lymphoma were further reviewed for signalment, presenting complaint, clinical signs observed on physical exam, diagnostic testing performed, and treatments administered. Postmortem gross and histologic findings were reviewed.

RESULTS
7 out of 35 rats were diagnosed with lymphoma, either ante-mortem or postmortem. The most common presenting complaint that was present in all rats with lymphoma was respiratory abnormalities. Five out of 7 rats had radiographs performed, all of which had abnormalities noted in the thoracic cavity including pulmonary nodules, cranial mediastinal widening, or alteration to the cardiac silhouette. Diagnosis via cytologic aspirates was performed in 2 cases and each was diagnostic for lymphoma; however, even with treatment, survival time following initiation of chemotherapy was short (less than or equal to 24 days). The definitive diagnosis in the remainder of the cases was via necropsy.

CLINICAL RELEVANCE
Results suggest that lymphoma is a common neoplastic disease in rats and a thorough diagnostic work-up is indicated in any rat that presents for general malaise or respiratory signs.
Investigation of the Performance of Cotton/Polyester Blend in Different Yarn Structures
Authors: Babaarslan Osman , Shahid Md Abul , Okyay Neslihan 
Published: June 2022

Abstract
The demand for polyester fiber is increasing gradually day by day. Because of its good strength, low manufacturing cost, and ease of modification, polyester fiber has distinct characteristics, whereas cotton is well known for its comfort. Blending these fibers improves the performance of yarns. In this study, cotton/polyester was blended in different ratios to evaluate yarn performance. Three groups of yarn: rigid, core, and dual-core-spun, have been produced to examine the yarn’s performance. From the study, it has been found that increasing the polyester blend ratio increases the yarn strength and elongation but decreases the yarn unevenness and imperfections. Among the group, having more core components decreases yarn strength, unevenness, and imperfection but increases elongation. From the statistical analysis, except strength, all other properties have good interaction on yarn type and blending ratio. Pearson correlation also indicated that elongation and hairiness have a good correlation with yarn type where, except for hairiness, all other properties have shown a strong positive correlation on blending ratio.