bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymph Node Yield/Ratio, Neutrophil‐Lymphocyte Ratio: Prognostic Factors in cN0 Laryngeal Carcinoma
Authors: Salem Eman Hamdy , Habaza Fedaey Ramadan , Ebada Hisham Atef , Abu Shady Eslam Farid , Elkotamy Somaya Noaman , Thabet Ahmed Hossam , Abdelmeguid Ahmed Salama , Kamal Elsharawy , Hamza Ashraf , Abdelaziz Mahmoud , Tawfik Ali , Abd El‐Fattah Ahmed Musaad 
Published: January 2025

ObjectivesThe aim of this study was to investigate the role of lymph node yield (LNY), lymph node ratio (LNR), and neutrophil to lymphocyte ratio (NLR) as prognostic factors, their impact on survival in patients with advanced laryngeal squamous cell carcinoma (LSCC).MethodsThis multicentric retrospective study included 195 patients with clinical N0 advanced laryngeal carcinoma who underwent total laryngectomy and/or total pharyngolaryngectomy over 5 years. The number of lymph nodes extracted (LNY) and the number of positive nodes were counted. The lymph node ratio “LNR” was calculated as follows: (positive nodes /LNY). Moreover, neutrophil to lymphocyte ratio (NLR) was calculated and documented for analysis.ResultsThe mean 5‐years DFS and overall survival (OS) was 33 and 35 months. The following were statistically significant factors negatively associated with overall survival; LNR (p = 0.047), NLR > 7 (p = 0.05), preoperative tracheostomy (p = 0.016), infiltrated safety margin (p = 0.01), postoperative radiotherapy (p < 0.001), N stage (p = 0.019), and unilateral neck dissection (p = 0.03). On the other hand, DFS was negatively associated with LNR (p = 0.001), N stage (p = 0.001), and infiltration of the surgical margins (p = 0.001).ConclusionLNY and LNR are both linked to survival outcomes following neck dissection in patients with clinical N0, locally advanced laryngeal carcinoma, where higher LNY and lower LNR correlated with improved survival and could be easily incorporated into cancer staging systems to aid in the prognostic stratification of patients. Additionally, NLR could act as a cost‐effective inflammatory biomarker predicting poor prognosis in LSCC.Level of evidenceIII Laryngoscope, 2025
Prolyl 4‐hydroxylase α‐subunit family regulation of type I collagen deposition and IL17RB/c‐Jun activation synergistically mediate choline dehydrogenase promotion of colorectal cancer metastasis
Authors: Yang Xiaowen , Li Yifei , Shen Xinzhuang , Wang Shuying , Zhang Zhuqing , Du Wenfei , Yang Chenglong , Jiang Xinyu , Zhang Xiaoyuan , Huang Yongming , Shen Wenzhi 
Published: January 2025

AbstractMetastasis continues to pose a significant challenge in tumor treatment. Evidence indicates that choline dehydrogenase (CHDH) is crucial in tumorigenesis. However, the functional role of CHDH in colorectal cancer (CRC) metastasis remains unreported. The study explored the functional role and mechanism of CHDH in CRC metastasis using human CRC tissues and a xenograft mouse model. CHDH expression was significantly higher in CRC compared to normal tissues and showed a positively correlation with CRC tumor‐nodes‐metastasis stage. CRC cell lines showed increased CHDH expression compared to normal controls. CHDH knockdown suppressed cell migration in vitro and tumor metastasis in vivo. Similarly, ectopic CHDH expression enhanced cell migration in vitro and tumor metastasis in vivo. Results suggested that CHDH affected the histone H3 trimethylation levels, which upregulated prolyl 4‐hydroxylase α‐subunit (P4HA) family gene (P4HA1/2/3) expression, further stabilizing collagen I expression and increasing IL17RB expression, which promoted downstream c‐Jun activation. Together, P4HA and IL17RB promote CRC cell metastasis. P4HA and c‐Jun inhibitors abolished CHDH‐mediated CRC cell metastasis in vitro and in vivo. Collectively, the above findings provide novel evidence that that CHDH mediates CRC cell metastasis and may be a promising target for metastatic CRC therapy.
Real‐Time Subcutaneous Arterial Navigation for Thinning of an Anterolateral Thigh Flap Using Photoacoustic Imaging and Projection Mapping: A Case Report
Authors: Tsuge Itaru , Saito Susumu , Munisso Maria Chiara , Kosaka Tomoko , Takaya Ayako , Liu Chang , Yamamoto Goshiro , Morimoto Naoki 
Published: January 2025

ABSTRACTThinning of anterolateral thigh flap is challenging. Anatomical studies have shown variations in arterial branching patterns in the subcutaneous layer, which were suspected to be the reason for the high frequency of thinning failures. We attempted to visualize subcutaneous arterial courses preoperatively and perform thinning of perforator flaps using this information appropriately. We accumulated evidence on the accuracy of noninvasive vascular visualization using photoacoustic tomography (PAT). In the present case, we applied a medical imaging projection system (MIPS), which enabled real‐time surgical navigation using indocyanine green (ICG) emission signals, to use photoacoustic information intraoperatively during the flap thinning procedure. A 69‐year‐old woman underwent half‐tongue resection using the pull‐through method for right‐sided tongue cancer. Preoperative PAT was performed 5 days before surgery. The 12 × 6‐cm area took ~8 min to scan. We used an ICG test card containing ICG‐positive control material cut into strips to show tentative artery lines by projection mapping. The transparent vascular map was laminated and sterilized. MIPS captured ICG fluorescence signals that penetrated the anterolateral thigh flap and continuously projected the purple area on the reverse side of the flap, guiding the position of the tentative arteries. A 20 × 6.5‐cm anterolateral thigh flap was elevated with the distal part of the reconstructed tongue and proximal de‐epithelialized part to fill the pull‐thorough tunnel in the submandibular region. Active bleeding was observed when cutting marginal fat tissue near the purple line of the distal ALT flap projected by MIPS. The study protocol did not include a highly invasive trial for MIPS‐guided thinning; therefore, we removed minimal marginal fat tissue. The ALT flap showed no postoperative complications while maintaining conversation and swallowing functions. We present the concept of subcutaneous arterial real‐time navigation surgery using PAT and MIPS for safe, easy, and fast flap thinning procedures in the future.
Examination of Elder Abuse and Death Anxiety in Older Adults With a Chronic Disease
Authors: Karaman Seda , Bahçecioğlu Turan Gülcan , Çayır Yılmaz Merve , Yilmaz Karabulutlu Elanur 
Published: January 2025

ABSTRACTAimThis study was conducted to examine elder abuse and death anxiety in older adults who had chronic diseases.DesignThe present study is a cross‐sectional and correlational study.MethodsThis study was conducted with 200 patients who met the research criteria and agreed to participate in the study and who were admitted to the internal medicine outpatient clinics of a university hospital in Elazig, eastern Turkey. Data were collected by using ‘Descriptive Information Form’ Hwalek‐Sengstock Elderly Abuse Screening Test (H‐S/EAST) ‘Death Anxiety Scale (DAS)’.ResultsThe mean DAS score of 8.66 ± 2.87 was evaluated as high and the mean H‐S/EAST score of 6.41 ± 3.78 was evaluated as moderate risk of abuse. It was found that the independent variable H‐S/EAST total score affected DAS total score positively (β = 0.633) and explained 38% (p < 0.001). Among the variables included in the model, gender, age and employment status were found to be positive (β = 0.243, β = 0.222, β = 0.222) statistically significant predictors of H‐S/EAST total score. In addition, it was found that gender was a positive (β = 0.318) and statistically significant predictor of DAS total score (p < 0.05).ConclusionsOlder individuals with chronic illness have a moderate risk of abuse and a high level of death anxiety. As the risk of elder abuse increases, death anxiety also increases. In addition, gender is an important predictor of elder abuse and death anxiety. In line with these results, it is recommended to identify groups with high potential for abuse, to organise awareness‐raising training programs to prevent abuse and to conduct evaluations for abuse and death anxiety at regular intervals. Also, the results of this research will contribute to nursing literature and will be useful for future interventional research.Public ContributionThere is no public contribution.
Mental Health Services for Serious Mental Illness: Scoping Review of Randomised Controlled Trials
Authors: Roson Rodriguez Pablo , Chen Xiao , Arancibia Marcelo , Madrid Eva , Shokraneh Farhad , Adams Clive E. , Franco Juan Víctor Ariel 
Published: January 2025

ABSTRACTAimsThis review aims to classify the evidence from randomised controlled trials (RCTs) on mental health services (MHS) for people with serious mental illness (SMI) available in the Cochrane Schizophrenia Group's (CSzG) specialised register.DesignScoping review.MethodsWe retrieved and screened RCTs of service‐level interventions considering non‐pharmacological approaches for mental healthcare of the CSzG register. We classified and collected the main characteristics of the RCTs using a customised data extraction and charting form based on DESDE‐LTS classification.ResultsWe included 233 out of 262 total trial registries. Most of the studies were conducted in China, 136 (58%), 57 (24%) North America and 26 (11%) Europe. We classified the studies as ambulatory assistance 80 (34%), day services/out‐patient care 38 (16%), residential services 44 (19%), accessibility to care 19 (8%), information/assessment 39 (17%), self‐help and voluntary help 10 (4%), e‐health 52 (22%), and discharge services 17 (7%).ConclusionsWe found a large number of trials that investigated the effects of mental health services for people with SMI. Trials classification was difficult due to the poor report of the characteristics of these complex interventions. This database can be used to plan and prioritise systematic reviews according to the needs of stakeholders.Relevance StatementThe study is of interest to mental health nursing because it studies the different services in which nurses play a fundamental role with implications in the nursing practice, education, research or leadership and management.
Neurobiology of COVID‐19‐Associated Psychosis/Schizophrenia: Implication of Epidermal Growth Factor Receptor Signaling
Authors: Nawa Hiroyuki , Murakami Masaaki 
Published: January 2025

ABSTRACTCOVID‐19 exhibits not only respiratory symptoms but also neurological/psychiatric symptoms rarely including delirium/psychosis. Pathological studies on COVID‐19 provide evidence that the cytokine storm, in particular (epidermal growth factor) EGF receptor (EGFR, ErbB1, Her1) activation, plays a central role in the progression of viral replication and lung fibrosis. Of note, SARS‐CoV‐2 virus (specifically, S1 spike domain) mimics EGF and directly transactivates EGFR, preceding the inflammatory process. In agreement, the anticancer drugs targeting EGFR such as Nimotuzumab and tyrosine kinase inhibitors are markedly effective on COVID‐19. However, these data might raise a provisional caution regarding implication of psychiatric disorder such as schizophrenia. The author's group has been investigating the etiologic and neuropathologic associations of EGFR signaling with schizophrenia. There are significant molecular associations between schizophrenia and EGFR ligand levels in blood as well as in the brain. In addition, perinatal challenges of EGFR ligands and intraventricular administration of EGF to rodents and monkeys both resulted in severe behavioral and/or electroencephalographic endophenotypes relevant to this disorder. These animal models also display postpubertal abnormality in soliloquy‐like self‐vocalization as well as in intercortical functional connectivity. Here, we discuss neuropsychiatric implication of coronavirus infection and its interaction with the EGFR system, by searching related literatures in PubMed database as of the end of 2023.
The Role of Integrated Governance Principles in the Fight Against Corruption: A Configurational Analysis
Authors: Zarghami Seyed Ashkan 
Published: January 2025

ABSTRACTGood governance offers a transformative approach to controlling corruption; however, existing literature on the governance‐corruption nexus is limited by two significant flaws: (1) it overlooks the combined effects of governance principles on corruption levels, and (2) it relies on traditional statistical methods rooted in correlational arguments that fail to address asymmetric problems, where factors that drive success in some cases may have little or no impact in others. To overcome these shortcomings, this research applies fuzzy set qualitative comparative analysis (fsQCA) to data from 32 European countries, uncovering multiple configurations that lead to successful corruption control. Drawing on institutional theory, the findings highlight three essential strategies: governments must legitimate their actions by building public consensus, securing the support of political parties and legislatures, and leveraging media to establish cognitive legitimacy. Additionally, open systems theory reveals that governments must move beyond internal governance, fostering dynamic interactions with their external environments through policy feedback and societal consultation. The study provides practical insights for policymakers, outlining specific combinations of governance principles that are necessary and complementary for effectively mitigating corruption.
Genomic and Clinicopathological Characterization of CRLF2‐Rearranged Mixed Phenotype Acute Leukemia
Authors: Han Lina , Zheng Ruifang , Fuda Franklin , Cantu Miguel D. , Koduru Prasad , Jaso Jesse M. , Weinberg Olga , Germans Sharon , Chen Mingyi , Xu Jing , Chen Weina 
Published: January 2025

ABSTRACTRearrangements of cytokine receptor‐like factor 2 gene (CRLF2) are present in ∼50% of B‐lymphoblastic leukemia/lymphoma (B‐ALL) with BCR::ABL1‐like features. Herein, we report three patients with CRLF2‐rearranged mixed phenotype acute leukemia (MPAL). All three cases were B/myeloid MPAL in young patients harboring P2RY8::CRLF2 or IGH::CRLF2 with additional genomic alterations in signaling (JAK and RAS) and cell cycle (CDKN2A/B) pathways, a genomic profile similar to that in BCR::ABL1‐like B‐ALL. Our study is the first case series to demonstrate clinicopathological and genomic features of this underrecognized entity. We recommend upfront genetic/molecular testing to timely diagnose and further characterize MPAL with BCR::ABL1‐like features.
Zeolitic imidazolate framework‐8 nanocrystals synthesized and decorated carbon fibers by electrophoretic deposition for enhancing interfacial properties of epoxy‐based composites
Authors: Lei Xue , Li Xiaoyu , Sun Bin , Zhou Xinyu , Chen Peng , Liu Ningning , Zhao Min , Zhang Yushen , Huang Yudong , Wang Caifeng 
Published: January 2025

AbstractZeolitic imidazolate framework‐8 (ZIF‐8) was used to enhance the interfacial strength of composites due to its large specific surface area, uniform pore size, and high stability. Morphology‐controllable ZIF‐8 nanocrystals were synthesized by solvent method and a layer of small‐sized and height crystalline ZIF‐8 was deposited on carbon fibers via an efficient electrophoretic deposition (EPD) way. The results showed that interlaminar shear strength (ILSS) and tensile strength (TS) of carbon fibers/epoxy composites and the TS of carbon fiber were enhanced by 43.56% and 25.48%, respectively. The strong interfacial adhesion strength between carbon fibers and epoxy was attributed to improving the wettability, ionic interaction and the mechanical interlocking effect induced by porous ZIF‐8, which led to effective energy absorption and load transfer. This highly efficient and controllable method is believed to improve the mechanical properties of carbon fiber composites for a wide range of industrial uses.Highlights
ZIF‐8s in different sizes and morphology were synthesized by solvent method.
MOF was deposited firstly onto carbon fibers though electrophoretic deposition.
Materials Studio was used to evaluate the strong anchoring strength.
ILSS of composites was enhanced by 43.56%.
Impact damage prediction method of glass/carbon fiber hybrid composites based on particle swarm optimization–backpropagation neural network
Authors: Chen Long , Lu Licheng , Gu Demeng , Liu Zhanqiang 
Published: January 2025

AbstractDamage to glass/carbon fiber reinforced hybrid composites from ballast impacts was a critical risk during high‐speed rail operation. In this study, strain sensors were employed to predict the maximum strain values induced by impact. Additionally, a finite element model (FEM) was established to obtain impact signal datasets. Train speed, maximum ballast diameter, and impact angle were selected as signal features. A particle swarm optimization–backpropagation neural network (PSO‐BPNN) damage prediction model was developed and optimized using the response surface methodology. The optimization improved prediction accuracy by 43% compared to the unoptimized model, reducing the mean squared error to below 0.0015%. Different sensor monitoring layout schemes were proposed and the results showed that the diagonal sensor layout achieved the highest monitoring accuracy, with a mean squared error of 0.0043%. The PSO‐BPNN model achieved a prediction success rate of 96%.Highlights
Integrating FEM with machine learning enables real‐time composite damage prediction.
Hyperparameter optimization enhanced the PSO‐BPNN model's accuracy.
Model prediction accuracy exceeds 96%.
The effect of different sensor layouts on prediction accuracy was tested.
Enhancing interfacial adhesion in carbon fiber‐reinforced composites through polydopamine‐assisted nanomaterial coatings
Authors: Sharma Prabhjot , Sharma Sahendra P. 
Published: January 2025

AbstractThis study explores the surface modification of carbon fiber (CF) with multi‐walled carbon nanotubes, graphene, and zinc oxide nanoparticles to improve interfacial adhesion in carbon fiber‐reinforced composites. A polydopamine (PDA) layer was used as a coupling agent to enhance the deposition and uniformity of the nanomaterial coatings on CF. The novelty lies in using PDA, which mimics mussel adhesive proteins, offering robust adhesion due to its amine and catechol functional groups. Elemental mapping through energy dispersive x‐ray spectroscopy, along with Fourier transform infrared (FTIR) and x‐ray diffraction analyses, confirmed the successful nanomaterial deposition while preserving the CF's graphitic structure. Nanoparticle structures at the nano‐level were examined under a transmission electron microscope. Contact angle measurements showed improved wettability, decreasing from 85.9° to 52.8°, and increasing surface energy from 5.10 to 44.1 J/m2, indicating better adhesion potential. The modified CF surface demonstrated improved interfacial bonding between the matrix and CF making them promising candidates for applications in hydrogen storage systems and energy storage devices, such as structural supercapacitors and batteries.Highlights
Surface modification of carbon fibers to enhance interfacial properties.
Nanomaterials were grown in a two‐step process on catalyst‐pretreated carbon fibers using dip coating.
Uniform nanomaterial coating on carbon fibers confirmed by field emission scanning electron microscope analysis.
Increased functionality of carbon fibers demonstrated by FTIR spectra.
Improved wettability and adhesion confirmed by contact angle and surface energy measurements.
Breakdown field strength and corona resistance of SiTiB/EP nanocomposites
Authors: Wang Boxuan , Chen Hao , Zhao Wei , Weng Ling , Sun Minghao , Zhang Jing , Yin Shuang , Jiang Mingyue , Wang Chunping , Shi Xiangyu 
Published: January 2025

AbstractThis paper describes the process of designing and creating SiTiB nanocomposite oxides by utilizing phenyltriethoxysilane (PTES), tributyl borate, and butyl titanate as monomers. The SiTiB/EP nanocomposite was then created using ultrasonic dispersion and thermal curing. Investigation of the effects of different doping levels of SiTiB nanocomposite oxides on the dielectric properties, breakdown strength, corona resistance lifetime, volume resistivity, and electrical aging threshold of nanocomposites. The findings indicate that the introduction of SiTiB nanocomposite oxides in epoxy resins (EPs) does not result in the growth of the dielectric loss of the nanocomposites. With the rise in SiTiB nanocomposite oxide doping, the breakdown strength of SiTiB/EP nanocomposites exhibited a trend of initially augment and then decline, reaching a peak value of 289.2 kV/mm when the doping amount was 6 wt%. The corona‐resistant lifetime of SiTiB/EP nanocomposites exhibited a trend of initially augment and then decline with the rise of SiTiB nanocomposite oxide doping, and the maximum value of corona‐resistant lifetime was 311 min when the doping amount was 6 wt%, which was 5.03 times of the pure EP. The experimental results demonstrate that the incorporation of SiTiB nanocomposite oxides can enhance both the breakdown strength and corona‐resistant lifetime of the nanocomposites, without causing an increase in their dielectric loss.Highlights
SiTiB composite oxides were designed and synthesized.
Analyzing the properties of SiTiB/EP composites with different doping levels.
SiTiB/EP composites have low dielectric loss.
SiTiB/EP composites have a longer corona‐resistance lifetime.
SiTiB/EP composites have high breakdown field strengths.
Characterizing the In Utero Phenome of the Chiari II Malformation—A Network Medicine Approach, Using Fetal MRI
Authors: Shi Hui , Prayer Daniela , Leinkauf Joel , Tischer Johannes , Li Xu , Kienast Patric , Khalaveh Farjad , Binder Julia , Kasprian Gregor 
Published: January 2025

ABSTRACTObjectiveTo apply a network medicine‐based approach to analyze the phenome of the prenatal fetal MRI and biometric findings in the Chiari II malformation (CM II) to detect specific patterns and co‐occurrences.MethodA single‐center retrospective review of fetal MRI scans obtained in fetuses with CM II was performed. Co‐occurrence analysis was utilized to generate a phenotypic comorbidity matrix and visualized by Gephi software. Traditional univariate regression and geometric thin‐plate spline methodology were used to elucidate the mechanisms underlying the relationships between morphometric measurements and geometric landmarks of the spine, skull, and brain deformations.ResultsThe CM II phenome consists of 35 nodes interconnected by 979 edges with a density of 0.828. Key “hubs” identified within this network include spinal bony defects, reduced posterior fossa dimensions, and vermis ectopia. The brain edema phenotype appearing only in the fetal stage but disappearing after postnatal surgery, links to increased postnatal morbidity and demonstrates distinct shape patterns by geometric analysis. Traditional univariate regression reveals correlations among spinal defects, posterior fossa dimensions, and caudal extent of vermis ectopia. The degree of brain rearrangement versus spinal bony rearrangement shows a correlation (r = 0.721, p = 0.0023) by partial least‐squares analysis.ConclusionThe CM II prenatal phenome is a multifaceted network centered around three key elements—spinal bony defects, small posterior fossa, and vermis ectopia—with strong interconnections. Fetal brain edema emerged as an exclusively prenatally detectable and transient phenotype of prognostic relevance.