bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living Ethics: a stance and its implications in health ethics
Authors: Racine Eric , Ji Sophie , Badro Valérie , Bogossian Aline , Bourque Claude Julie , Bouthillier Marie-Ève , Chenel Vanessa , Dallaire Clara , Doucet Hubert , Favron-Godbout Caroline , Fortin Marie-Chantal , Ganache Isabelle , Guernon Anne-Sophie , Montreuil Marjorie , Olivier Catherine , Quintal Ariane , Senghor Abdou Simon , Stanton-Jean Michèle , Martineau Joé T. , Talbot Andréanne , Tremblay Nathalie 
Published: October 2022

Abstract

Background
Moral questions are vital questions because they concern what is esteemed to be the best action, the best choice and, ultimately, the best life to live. Health ethics which aims to address these moral questions has contributed to moving ethics toward more experience-based and user-oriented ethics theory and methodology. Despite this, current approaches remain an incomplete lever for human development and flourishing. This context led us to imagine and develop the stance of a “living ethics”, a radically participatory and situated form of ethics which we describe in this inaugural collective and programmatic paper.
Methods
We followed a participatory discussion and writing process known as instrumentalist concept analysis. Initial informal local consultations were undertaken about pragmatic ethics, and from these conversations emerged the current project. An exploratory literature review was undertaken, and a diverse working group of 21 co-authors was assembled. The working group held a total of 8 workshop-like meetings supported by prior reading and iterative revision of a shared draft document accessible through an online platform. Meetings were video-recorded and transcribed to support this process. Four subgroups were created to further the working group’s reflections in specific domains of health ethics.
Results
In its first sense, a living ethics designates a form of ethics attentive to human experience and the role played by morality in human existence. In its second sense, a living ethics represents an ongoing effort to interrogate and scrutinize our moral experiences to promote the engagement of both individuals and communities in envisioning and enacting scenarios which correspond to their flourishing as authentic ethical agents. Living ethics bears specific theoretical, methodological, and practical implications in various areas of health ethics activity such as clinical and organizational ethics, health policy and public health, health ethics research, and learning and teaching health ethics.
Conclusions
Living ethics encourages meaningful participation of stakeholders and reflects a commitment to the existential nature of moral affairs. Looking forward, there is a need for ongoing dialogue about the nature of living ethics and the methodological practices coherent with this orientation. We hope to build on this idea to initiate collaborative projects locally and internationally.
Measurement properties of 72 movement biomarkers aiming to discriminate non‑specific chronic low back pain patients from an asymptomatic population
Authors: Moissenet Florent , Armand Stéphane , Genevay Stéphane 
Published: October 2022

Abstract
The identification of relevant and valid biomarkers to distinguish patients with non-specific chronic low back pain (NSCLBP) from an asymptomatic population in terms of musculoskeletal factors could contribute to patient follow-up and to evaluate therapeutic strategies. Several parameters related to movement impairments have been proposed in the literature in that respect. However, most of them were assessed in only one study, and only 8% were evaluated in terms of reliability, validity and interpretability. The aim of this study was to consolidate the current knowledge about movement biomarkers to discriminate NSCLBP patients from an asymptomatic population. For that, an experimental protocol was established to assess the reliability, validity and interpretability of a set of 72 movement biomarkers on 30 asymptomatic participants and 30 NSCLBP patients. Correlations between the biomarkers and common patient reported outcome measures (PROMs) were also analysed. Four biomarkers reached at least a good level in reliability (ICC ≥ 0.75) and validity (significant difference between asymptomatic participants and NSCLBP patients, p ≤ 0.01) domains and could thus be possibly considered as valuable biomarkers. These biomarkers are all related to the lumbar sagittal angle during trunk forward bending task. They are in general weakly correlated with patient reported outcome measures, arguing for a potential interest in including related musculoskeletal factors in the establishment of a valuable diagnosis and in guiding treatment response.
Levulinic acid production from lignocellulosic biomass using lignin-catalyst
Authors: Santos Miquéias Gomes dos , Fogarin Henrique Maziero , Silva Débora Danielle Virginio da , Dussan Kelly Johana 
Published: October 2022

Abstract
Purpose
This work developed a new solid carbonaceous acid catalyst on lignin-based and used it to convert cellulose into levulinic acid (LA), resorting a mixture of straw and sugarcane bagasse (1:1 ratio) as reagent and catalyst.
Methods
Pretreated straw and sugarcane bagasse in dry block reactors. The solid/liquid ratio for all tests was 1:20 at 110°C. Used a 22 rotational central composite design to optimize cellulose extraction and lignin precipitation, cellulose extraction: varying NaOH concentration (0.2 to 5% w/v) and reaction time (3 to 117 min), and lignin precipitation: testing different pH values (3 to 10) and residence time (6 to 69 min). Synthesized the catalysts through an incomplete lignin carbonization followed by sulfonation. Cellulosic pulp was treated with the catalyst at 140°C (1:8 solid/liquid ratio).
Results
Under reaction conditions of 110°C, 117 min, solid/NaOH (4.4% w/v) and 1:20 ratio, more than 91% of the lignin dissolved into the black liquor, recovering a solid with a cellulose content higher than 78%. Furthermore, lignin was fully recovered as precipitate by reducing the black liquor pH to 3 (11 g of recovered precipitate/liter of liquor) and used to synthesize a 7.3 mmol/g total acid site density catalyst, which converted the cellulose up to 17.11% and obtained LA yields of up to 38.55%, when applied an 8:10 catalyst/cellulose ratio (w/w).
Conclusion
The proposed process has the potential to enable the inclusion of LA among the by-products of the national sugar-energy sector, increasing its competitive potential.
Treatment with quercetin increases Nrf2 expression and neuronal differentiation of SVZ-derived NPSCs.
Authors: Ebrahimi Ali , parivar kazem , Roodbari Nasim Hayati , Eidi Akram 
Published: October 2022

Abstract
The presence of neural precursor stem cells (NPSCs) in some parts of the adult brain has been proven in recent years, and it has opened up a new approach for the treatment and recovery of the defects and diseases associated with the central nervous system (CNS). Besides, the potency of these types of cells with a therapeutic viewpoint is another beneficial facet of the application of NPSCs in cell biology. Quercetin, as an herbal flavonoid, has been extensively investigated and shown to have numerous restoratives, inhibitory, and protective effects on some cell-lines and disorders. In this research, we aimed to investigate the impact of quercetin, on expression of Nrf2 gene as one of the antioxidant pathway and proliferation and differentiation of NSCs derived from the subventricular zone (SVZ) of the adult brains of rats. The brains of adult rats were dissected, and the two SVZs of the brain of each animal were removed. The obtained cell suspension was cultured for one week to achieve neurospheres. When the cells reached, quercetin was treated with the cultured cells at the concentrations of 1, 5, and 15 µM to evaluate the impact of this substance on the proliferation and differentiation of NSCs after one week. Cell identification was performed by RT- PCR, survival test with MTT assay, quantification of images with Image-J and cells were counted. The results indicated that the quercetin increases expression of Nrf2 at concentration above 5 µM. Also differentiation and proliferation rate of NSCs is affected by various concentrations of quercetin in a dose-dependent manner so that 1µM quercetin had the least, and 15 µM quercetin showed the most effects on cell differentiation. However, 1 µM quercetin exhibited no significant cell toxicity, but the most antiproliferative potential showed when treated with 15 µM concentration quercetin. These findings confirm previous information on the dose-dependent effect of quercetin on proliferation and differentiation of cell.
VOCs concentration, SOA formation contribution and festival effects during heavy haze event: a case study in Zhengzhou, Central China
Authors: Guo Jiahua , Xu Qixiang , Yu Shijie , Zhao Bingnan , Zhang Meng 
Published: October 2022

Abstract
In this study, online ambient volatile organic compounds (VOCs) were collected at an urban site of Zhengzhou in Central China during February 2018. The VOCs characteristics, source contributions and the Chinese New Year (CNY) effects have been investigated. During the sampling period, three haze periods have been identified, with the corresponding VOCs concentrations of 92 ppbv, 62 ppbv and 83 ppbv; in contrast, the concentration during non-haze days was found to be 57 ppbv. In addition, the festival effects of the Chinese New Year (CNY) were investigated, and the concentration of particulate matter precursor decreased significantly. Meanwhile, firework displaying events were identified, by the emission intensity had been greatly changed. Both potential source contribution function (PSCF) and the concentration weighted trajectory (CWT) models results indicated that short-distance transportation was the main influencing factor of the local VOCs pollution, especially by transport from the northeast. Source contributions results by the positive matrix factorization (PMF) model showed that vehicle exhaust (24%), liquid petroleum gas and natural gas (LPG/NG, 23%), coal combustion (21%), industrial processes (16%), and solvent usages (16%) were the major sources of ambient VOCs. Although industry and solvents have low contribution to the total VOCs, their SOA contribution were found to be relatively high, especially in haze-1 and haze-3 periods. The haze-2 period had the lowest SOAp during the sampling period, this is mainly caused by to the reduction of industrial and solvent emission due to CNY.
Information Use, Seeking Behaviors, and Barriers to Evidence-Based Information at a Large UK Teaching Hospital
Authors: Lagojda Lukasz , O'Connell Bridget , Brown Anna , Dekker Natasha S. den 
Published: October 2022

Abstract
Objective
Understanding whether clinicians use evidence-based information and if their information-seeking behaviours allow for retrieval of creditable information is key for clinical library service to develop a strategic action plan in supporting clinicians in utilising evidence in practice. This study explores the information use and the factors affecting access to evidence-based information amongst clinicians at an acute teaching hospital.
Methods
An anonymous online survey was distributed to all staff via SurveyMonkey®. Data were curated in Microsoft Excel and managed using SPSS v26. Graphs were generated using GraphPad PRIMS software.
Results
Ninety-three per cent of clinicians used EBI in practice, primarily for patient care and education. Clinicians employed a range of seeking behaviours to retrieve EBI, which change based on how often EBI was needed. The barriers to EBI varied between clinical professions but ‘time’ was the most consistent factor. The belief of evidence-based practice (EBP) being not part of the job role was the overwhelming factor for not using EBI.
Conclusions
Our findings are consistent with previous reports describing significant impact of time and access to IT resources on whether search for evidence-based information. This study allowed us to design a strategy aimed at clinicians to provide support in utilising evidence-based knowledge
Evidence of Sulfuric-acid Emitted from the Underground Coal-fire at Wuda of the Inner Mongolia of North China
Authors: Gao Xiulong , Wang Jing , Tie Cai , Liang Yanci , Liang Handong 
Published: October 2022

Abstract

The emission of pollutants from the continuous spontaneous combustion of coal seams and coal gangue may leads to serious destruction of the global environment and ecology in the 21st century. The persistent coal fire in the Wuda coalfield in Inner Mongolia, China is a typical coal fire in north China, and it attracts global attention. In this paper, Coal fire sponge (CFS) samples were collected from the Wuda coalfield and tested in the laboratory. The results show extremely low pH value (0.30 ~ 0.96, n = 33) and extremely high sulfate concentration (125 ~ 427mg/g, n = 33). It is confirmed that 90% of the sulfate exists in the form of sulfuric acid according to further analysis. This fact reveals that the emission of sulfur from spontaneous combustion of coal and coal gangue is mainly in the form of sulfuric acid (H2SO4·nH2O), which comes from conversion of sulfur in coal and coal gangue, and the accompanying emission of sulfur dioxide is secondary. Glauber's salt condensate, which is common in exposed rock cracks and voids in the Wuda coalfield, further indicates that at least in this coalfield, the spontaneous combustion of underground coal seams and coal gangue will inevitably emit sulfuric acid into the atmosphere. The strong water absorption of sulfuric acid droplets and the resulting condensation and nucleation in the atmosphere are the key factors leading to regional haze events and global climate radiation suppression. Anyway, this work reveals an important and unknown source of sulfuric acid emissions, and it is likely to be another way for coal fires to affect and endanger the global environment and ecology.
Characterization and Fine Mapping of a White Stripe Leaf Mutant in Rice
Authors: Hu Binhua , He zhiyuan , Xiang Xiaoli , Li Hui , Du Anping , Wang Minxia , Bai Yulu , Wang Lanying , Zhang Cong , Wang Ping , Pu Zhigang 
Published: October 2022

Abstract
Leaf color affects the efficiency of photosynthesis, and leaf color mutants are important genetic materials for studying the mechanisms of photosynthesis, chlorophyll biosynthesis, and chloroplast development in rice. In this study, a white-striped leaf mutant, wst1, was obtained from the mutant population of the indica restorer line ‘Chuanhui 907’ (R907) when treated by 60Co-γ radiation. Compared to the wild-type, the wst1 mutant showed normal leaf color before tillering and white stripes on the leaf and leaf sheaths after tillering. The chlorophyll and carotenoid contents were significantly reduced, and the thylakoids of chloroplasts developed abnormalities in wst1 plants in the tillering stage. The results of agronomic trait analysis showed that the number of effective panicles, plant height, seed setting rate, and 1000-grain weight of the wst1 mutant were significantly lower than those of the wild-type. Genetic analysis revealed that the phenotype of the wst1 mutant is controlled by a pair of recessive nuclear genes. The candidate gene was mapped to a 72 kb region between the InDel markers M6 and M12 on the short arm of chromosome 1 using molecular marker linkage analysis. Candidate genes were sequenced on the interval, and a G base was replaced by A at the 6972nd position on the 16th exon of LOC_Os01g01920, which encoded a previously reported protein containing the HD domain, WSF3/WFSL1, leading to alternative splicing, causing a 104 bp deletion in the coding region, and resulting in mistranslation after the 490 amino acid of the encoded protein translation in wst1. RT-qPCR analysis showed that the expression levels of most genes related to chlorophyll synthesis and chloroplast development were significantly altered in wst1 plants. Our study identified a novel allele of wsf3 and wfsl1 mutant and provided a new genetic resource and theoretical basis for further understanding of the molecular mechanism of WST1 gene regulation of white-striped leaves in rice.
Psyche: The 5th “P” and its Impact on the Second Stage of Labor
Authors: Gimovsky Alexis , Rasiah Stephen , Vergara-Lopez Chrystal , Has Phinnara , Ayala Nina , Stroud Laura 
Published: October 2022

Abstract
Purpose
The objective of this study was to evaluate the impact of maternal preconception and antenatal depressive disorders on the duration of the second stage of labor and subsequent perinatal outcomes.
Methods
This is retrospective study of patients who reached the second stage of labor. Patients with a non-anomalous, singleton gestation in cephalic presentation were included. Participants were assigned to one of three groups: pre-conception only major depressive disorder (MDD), prenatal major depressive disorder, and non-depressed controls. The primary outcome was prolonged second stage of labor. Secondary outcomes included maternal and neonatal morbidities.
Results
172 patients were included. 24.4% (42/172) participants had preconception-only MDD, 42.4% (73/172) patients were categorized as having prenatal MDD, and 33.1% (57/172) patients were categorized as non-depressed controls. The second stage was prolonged in 13.8% (4/29) of the preconception MDD group, 8.3% (4/48) of the prenatal MDD group, and 10.0% (4/40) of the control group (p = 0.69). The adjusted pair-wise analysis between groups showed no significant difference in the duration of the second stage. There were significantly more cesarean births due to arrest of descent in the control group and prenatal MDD group compared to the pre-conception MDD group. No statistically significant differences were noted between the groups for adverse neonatal outcomes.
Conclusion
Maternal depressive disorders did not impact length of the second stage of labor or immediate perinatal outcomes in this cohort. However, further studies are needed to determine whether maternal depression impacts other perinatal outcomes related to the second stage of labor.
Graphene Family in the Acute Treatment of Migraine: Molecular Docking and Dynamics Simulation
Authors: Rezvantalab Sima , Imanpour Aylar 
Published: October 2022

Abstract
At present, the FDA approved some drugs for treating migraines such as Ubrogepant and Rimegepant by targeting the calcitonin-gene-related peptide receptor (CGRPR). Although nanomaterials have been recognized as useful as drug carriers or therapeutics for other diseases, there are few studies on migraine. Here, we study the graphene nanosheets with various functional groups including –COOH, -NH2, –COOH-NH2, -OH, and O interacting with calcitonin receptor-like receptor (CLR) in combination with receptor activity-modifying protein (RAMP1). This study uses molecular dynamics (MD) simulations to study the interaction between CLR/RAMP1 and graphene-family planar nanosheets: Gr, Gr-COOH, Gr-NH2, Gr-OH, Gr-O, and Gr-COOH&-NH2. The Ubrogepant was used to validate the results and comparison of the Gr-family performance. The MD simulation data revealed that Gr, Gr-OH, and Gr-COOH interacted with CLR/RAMP1 more intensely, due to changes in electrostatic interactions. Furthermore, the binding affinity of the nanosheets, as well as Ubrogepant toward the protein, have been calculated using docking. Docking analysis with both CLR fragment and CLR/RAMP1revealed similar trends in the interactions where Gr-OH has the strongest affinity in binding to the neuropeptide. Altogether, our study shows that three candidates; Gr-OH > Gr-COOH > pristine Gr can inhibit CGRPR binding by disrupting the protein’s structure. Significantly, the Gr-family outperformed Ubrogepant as an indicator of its potential anti-migraine applications. The results of this study provide detailed and reliable theoretical guidance for using the graphene family in treating migraine and can assist in the further development of new graphene-based materials.
Deficiency of LncRNA-CIRBIL promotes J-wave syndrome by enhancing transmural heterogeneity of Ito current
Authors: Jin Xuexin , Ma Wenbo , Zhang Yang , Gao Haiyu , Yin Dechun , Song Jiahui , Li Desheng , Shi Ling , Li Jialiang , Ma Jiudong , Zhang Lingmin , Shan Hongli , Lu Yanjie , Li Yue , Yang Baofeng , Pan Zhenwei 
Published: October 2022

Abstract
Transmural heterogeneity of Ito current is a major cause of J-wave syndrome (JWS), while the underlying molecular mechanisms remain elusive. The present study aims to explore the influence of Cardiac Injury-Related Bclaf1-Interacting LncRNA (lncCIRBIL) on cardiac J-wave syndrome and to delineate the molecular mechanisms. The plasma level of lncCIRBIL was reduced in JWS patients and cold-induced JWS mice. Knockout of lncCIRBIL increased the frequency of J-wave and the susceptibility to ventricular arrhythmia in mice. The transmural difference of KCND2 and Ito currents were dramatically increased in the right ventricle, but not the left ventricle of lncCIRBIL-KO mice. In contrast, cardiomyocyte-specific transgenic overexpression of lncCIRBIL produced the opposite effects. The human homologous conserved fragment of lncCIRBIL (hcf-CIRBIL) reduced Ito, downregulated action potential notch and prolonged APD20 in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). LncCIRBIL titrates the transmural heterogeneity of KCND2 by regulating UPF1 mediated mRNA decay. Inhibition of lncCIRBIL promoted J-wave syndrome by enhancing the transmural heterogeneity of Ito in the right ventricle. These findings imply that lncCIRBIL represents a potential therapeutic target for J-wave syndrome.