bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Invasive micropapillary ductal breast carcinoma
Authors: Namugenyi Kakia Anne Faith , Oladimeji Kelechi Elizabeth , Mthimba Alungile , Mzileni Chris , Oladimeji Olanrewaju 
Published: November 2022

Background: Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal breast carcinoma (IDC), with most cases characterized by lymph node metastasis and lymphatic vascular invasion. It is a ductal breast cancer subtype with a very high risk of recurrence and therefore requires special attention from breast cancer physicians and radiologists. Case: We present a case of an IMPC that has been followed up for two years since diagnosis and management. Based on clinical breast examination, ultrasound, and mammography, the initial diagnosis was a suspicious mass that required further investigation. Radiological and histological findings informed the diagnosis of a highly suspicious lesion, which turned out to be IMPC. The patient underwent surgery, left mastectomy with nodal dissection. During the 24-month follow-up, ultrasound and mammography revealed no evidence of local recurrence or involvement of the contralateral breast. Conclusions: This case reveals that invasive micropapillary carcinoma is a distinct but poorly recognized variant and subtype of invasive ductal carcinoma.
PSYCHOLOGICAL AND PHYSICAL SELF-CONCEPT OF A PERSON WITH NON-HETEROSEXUAL SEXUAL ORIENTATION
Authors: Kochetkova Tatiana N. 
Published: November 2022

The purpose of the work: to explore the characteristics of the self-concept of a person with a homosexual identity.
Methods and methodology of the work. Both qualitative and quantitative research methods were used for the purposes of the study, i.e., observation, conversation, projective techniques, testing. Data processing was carried out in Exsel and AtteStat. The study involved 32 respondents, 11 of whom identified themselves as women in a male body, 21 – as men being sexually attracted only to representatives of their own sex. The average age of the participants was 24.7.
Results of the study. All participants in the study have difficulty in establishing social contacts, having a conflicting self-concept, which they consider real, as well as a disharmonious ideal self-concept due to an unstable self-esteem and ambivalent or negative self-attitude. They gravitate towards co-dependent relationships, they have failed to resolve interpersonal conflicts, which are primarily associated with their parents and close relatives. Both the psychological self-concept and the body image are conditioned by the respondents’ dependence on the opinions of others, which prevents them from accepting their own personality, being different from the overwhelming majority due to the sexual orientation, which is still stigmatized in society.
Practical implications. The results of the study might be useful in practice, helping to select the appropriate tools, to identify the nature of intrapsychic and interpersonal conflicts, to carry out consultative, psychocorrectional and psychotherapeutic work aimed at helping to accept one’s own psychological and physical self-concept.
FEATURES OF TECHNICAL TRAINING OF YOUNG VOLLEYBALL PLAYERS
Authors: Agafonov Sergey V. , Shirin Alexander A. , Zavodny Nikita A. , Kaznacheev Vladimir V. 
Published: November 2022

Introduction. One of the most important methodological conditions for the growth of technical skills in volleyball already at the early stages of long-term training is the relationship between the structure of movements and the level of development of physical qualities and abilities. Compliance of the level of physical fitness of an athlete with the parameters of his sports equipment possession is the most important condition for an effective method of technical training in volleyball. The article presents the results of a study aimed at the implementation of training programs for the technical training of 9-10 year old volleyball players.
Purpose: to develop and experimentally test the effectiveness of exercise complexes for the development of physical and psychomotor abilities of young volleyball players (muscle strength of the hand and phalanges of the fingers, the speed of contraction of the muscles of the hands, the ability to differentiate muscle tension, etc.), which are of decisive importance in the process of technical training of athletes at the initial stage.
Methodology. The following methods were used in the study: generalization and analysis of literary sources; pedagogical testing; biomedical; pedagogical observation; statistical data processing.
Results. The conducted research confirmed the put forward hypothesis that the development of technical elements in volleyball already at the early stages of training is determined by the proper level of development of special physical qualities and abilities. At the end of the pedagogical experiment using the new methodology, volleyball players from the experimental group significantly outperformed the athletes from the control group in almost all parameters of technical readiness.
Application area. The developed sets of exercises can be used by sports teachers when compiling work programs within the framework of basic and additional education at the Volleyball course.
Polyols - What do we know about their impact on the gut microbiome?
Authors: Wojtuś Magda , Tomaszuk Sebastian , Wąsik Karolina 
Published: November 2022

Introduction and purpose:
Even though sweeteners’ popularity is increasing as they are approved by the Food and Drug Administration (FDA) and generally considered to be safe, their whole impact on the human body is still confusing. Polyols are among one of the most used sweeteners, therefore in this review we will focus on their impact on the gut microbiome as this community of various bacteria influences many aspects of overall health.
Brief description of the state of knowledge:
The current conclusions mostly present prebiotic benefits of polyols and their ability to increase the number of Bifidobacteria, there is research supporting the evidence of it conducted on isomalt, maltitol, lactitol and xylitol. It is possible, as most of them are able to reach the colon. We also investigate other ways sweeteners are shaping the gut microbiome such as multiplication of short chain fatty acids (SCFAs) or decreasing the numbers of Clostridium difficile.
Conclusions:
The impact of polyols on the gut microbiome has many knowledge gaps. More long-term studies are needed in order to consider the individual diversity of the participants’ gut microbiota. In order to conduct more valuable conclusions dietary and lifestyle habits should be taken into consideration. All things considered, there is not enough data to clearly determine polyols' role in modifying the gut microbiota.
Palliative cancer patients pain reduction methods during opioid epidemic era
Authors: Sobańska Natalia , Bednarz Katarzyna , Banaś Patryk , Banasiak Aleksandra Paulina , Teichman Rafał , Kasprowicz Jakub , Pierzchała Jakub Rafał , Abram Kamila , Adamus Justyna , Hyjek Michał 
Published: November 2022

Introduction: Opioids are the most commonly used medication in palliative cancer pain treatment due to their proven effectiveness. However, modern anti-pain treatment concentrates not only on analgesics, but simultaneously on the detection of conditions affecting and intensifying pain sensation. Many studies have shown potential of other, non-opioidal palliative cancer pain treatment with additional positive effect on patient’s general quality of life.
Aim of the study: The purpose of our review is to introduce the issue of the use of opioids and draw attention to other non-opioidal pain reduction methods as well as to indicate directions for further potential researches.
Methods and materials: We have reviewed the literature available in the PubMed, Google Scholar, Science Direct database using the keywords: „cancer patients and opioids”; „pain and cancer”; „chronic pain”; „palliative cancer”. We excluded abstracts, comments, and non–English language articles.
Results:
The methods outlined in this review will not affect pain reduction to the same extent as opioids, but they offer a chance to reduce it to a level that allows patients to maintain a normal life. In the light of opioid epidemic era literature shows new approaches to treating pain such as analgesics, including antidepressants, anticonvulsants, Vitamins, cannabis and nonpharmacological methods and showing their potential for wider use in palliative cancer patients treatment.
Conclusion: Besides opioids, there are many factors that affect pain reduction, however, their analgesic potential require additional studies on larger groups of patients.
Detection of Persimmon Posture by a Convolutional Neural Network for Fully Automating the Peeling Process
Authors: Kaizu Yutaka , Miyanishi Yotaro , Todoriki Yuya , Furuhashi Kenichi , Imou Kenji 
Published: November 2022

Highlights

Robots have been developed for fully automated peeling, which is the main operation in the production of dried persimmons.

Vision sensors were used to pick and place persimmons that were originally placed in random orientations.

A convolutional neural network was used for fast and robust detection.

The roots of peduncles and positions of fruits were detected with high accuracy.

Abstract. The manufacturing process of dried persimmons includes peeling, drying, and finishing. Although a considerable part of this process is mechanized, manual labor is still required. The purpose of this study is to develop a robot machine vision system for placing persimmons onto a suction cup in a peeling machine to fully automate the peeling process. This article describes a method for detecting the position of the center of an entire persimmon fruit and the root of the peduncle in a two-dimensional image as a preliminary step to estimating the three-dimensional position and orientation of the persimmon, which is required for pick-and-place operations by a robot manipulator. A convolutional neural network (CNN) was used to ensure robust detection regardless of variations in the persimmon shape and surface color. The position of the fruit and the position of the peduncle root were detected with accuracies of 1.0 mm and 2.0 mm, respectively, when the calyx of the persimmon was facing sideways at the time of picking, and the directional accuracy was 3.2°. When placing the persimmon with the calyx facing up, the accuracies of the fruit position and the position of the peduncle root were 0.8 mm and 0.8 mm, respectively. The peduncle root position was detectable even if the peduncle was hidden by the calyx. The main contribution of this article is to confirm that a CNN can detect the center of a persimmon and the root of the peduncle with sufficient speed and accuracy for practical use, which is difficult to achieve with conventional image processing methods due to the variable shape and color of persimmons. Keywords: Automatic peeling machine, Calyx, Dried persimmon, Peduncle, Serial robot, YOLOv3.
Expression of SIX1b and SIX1c effector genes and banana resistance genes during Foc TR4 infection on banana cultivars
Authors: ULILALBAB AZIZAH RIDHA , WIDINUGRAHENI SRI , MASANTO MASANTO , SUBANDIYAH SITI , WIBOWO ARIF 
Published: November 2022

Abstract. Ulilalbab AR, Widinugraheni S, Masanto, Subandiyah S, Wibowo A. 2022. Expression of SIX1b and SIX1c effector genes and banana resistance genes during Foc TR4 infection on banana cultivars. Biodiversitas 23: 5314-5322. The relative expression SIX1 genes isolates of Foc TR4 and banana resistance genes have not been intensively studied. This study aimed to determine the expression of SIX1 genes of Foc TR4 and banana resistance genes. Twelve Foc TR4 isolates were collected from several regions in Indonesia. DSI analysis was performed to categorize their virulence levels. The representative Foc TR4 isolates from different virulence levels were artificially inoculated on the Musa acuminata Colla Cavendish subgroup and cv. Barangan and incubated for 48, 72, and 96 HPI. The expressed genes were quantitatively analyzed using the qPCR technique using primers to amplify SIX1b, SIX1c, chitinase, and PR-protein 1 genes. The results categorized the virulence of Foc TR4 isolates into moderate, virulent, and high virulent. The isolates of KJG and Batu-4 were selected for gene expression study representing moderate and high virulent groups, respectively. The results of in planta assay found that the expression of SIX1b, SIX1c, chitinase, and PR-protein1 was upregulated on the inoculated plants during the incubation period. However, the expression of these genes was increasingly upregulated in both bananas at early-stage inoculation. We assumed that plant defense genes of bananas might actively encounter the common virulence mechanisms of Foc TR4 at the initial stage of inoculation.
Comparison of Water Resistance for Modified Medium-Density Fiberboard
Authors: Irribarra Luis Molina , Kamke Frederick A. , Leavengood Scott 
Published: November 2022

Abstract
Commercial medium-density fiberboard (MDF) products, specifically manufactured for water resistance, were evaluated over 8 days under three water exposure regimes: 90 percent relative humidity, one-sided water spray, and one-sided wet pad. A three-cycle wet-pad and drying exposure test was also performed. Rate of swelling, extent of swelling, and irreversible thickness swelling were determined. Acetylated MDF (AMDF) had the best overall performance, followed by steam-injection pressed MDF (SMDF) and polymeric methylene-diphenyl-diisocyanate–bonded moisture-resistant MDF. The fastest rate of thickness swell and linear expansion occurred with exposure to one-sided water spray and the slowest with 90 percent relative humidity exposure. While AMDF was clearly superior after 24-hour exposure, the other MDF products were nearly identical. Significant difference in thickness swell and water absorption between moisture-resistant MDF and SMDF developed after 24 hours. Regardless of the method of water exposure, the trend of best to worst MDF performance was the same.
A protocol paper for the MOTION Study—A longitudinal study in a cohort aged 60 years and older to obtain mechanistic knowledge of the role of the gut microbiome during normal healthy ageing in order to develop strategies that will improve lifelong health and wellbeing
Authors: Phillips Sarah , Watt Rachel , Atkinson Thomas , Rajan Shelina , Hayhoe Antonietta , Savva George M. , Hornberger Michael , Burton Ben J. L. , Saada Janak , Cambell-Kelly Melissa , Rushbrook Simon , Carding Simon R. 
Published: November 2022

Background
Advances in medicine and public health mean that people are living longer; however, a significant proportion of that increased lifespan is spent in a prolonged state of declining health and wellbeing which places increasing pressure on medical, health and social services. There is a social and economic need to develop strategies to prevent or delay age-related disease and maintain lifelong health. Several studies have suggested links between the gut microbiome and age-related disease, which if confirmed would present a modifiable target for intervention development. The MOTION study aims to determine whether and how changes in the gut microbiome are associated with physical and mental capacity. A comprehensive longitudinal multiparameter study such as this has not been previously undertaken.

Methods
MOTION is a longitudinal prospective cohort study with a focus on gut health and cognitive function. 360 healthy individuals aged 60 years and older, living in East Anglia, UK will be recruited to the study, stratified into one of three risk groups (cohorts) for developing dementia based on their cognitive function. Participants will attend study appointments every six months over four years, providing stool and blood samples and a health questionnaire. Participants will also undergo physical measurements and cognitive tests at alternating appointments, and undergo Optical Coherence Tomography scans at 3 timepoints. Two subgroups of participants in the study will provide colonic tissue biopsies (n = ≥30 from each cohort), and brain imaging (n = 30) at two timepoints.

Discussion
This study will provide new insights into the gut-(microbiota)-brain axis and the relationship between age-associated changes in gut microbe populations and cognitive health. Such insights could help develop new microbe-based strategies to improve lifelong health and wellbeing.

Trial registration
This study is registered in the ClinicalTrials.gov Database with ID: NCT04199195 Registered: May 14, 2019.
Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature
Authors: Kaagaard Molly D. , Wegener Alma , Gomes Laura C. , Holm Anna E. , Lima Karine O. , Matos Luan O. , Vieira Isabelle V. M. , de Souza Rodrigo Medeiros , Vestergaard Lasse S. , Marinho Claudio Romero Farias , Dos Santos Flávia Barreto , Biering-Sørensen Tor , Silvestre Odilson M. , Brainin Philip 
Published: November 2022

BackgroundDengue virus can affect the cardiovascular system and men may be at higher risk of severe complications than women. We hypothesized that clinical dengue virus (DENV) infection could induce myocardial alterations of the left ventricle (LV) and that these changes could be detected by transthoracic echocardiography.Methodology/Principal findingsWe examined individuals from Acre in the Amazon Basin of Brazil in 2020 as part of the Malaria Heart Study. By questionnaires we collected information on self-reported prior dengue infection. All individuals underwent transthoracic echocardiography, analysis of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). We included 521 persons (mean age 40±15 years, 39% men, 50% urban areas) of which 253 (49%) had a history of dengue infection. In multivariable models adjusted for clinical and sociodemographic data, a history of self-reported dengue was significantly associated with lower LVEF (β = -2.37, P < 0.01) and lower GLS (β = 1.08, P < 0.01) in men, whereas no significant associations were found in women (P > 0.05). In line with these findings, men with a history of dengue had higher rates of LV systolic dysfunction (LVEF < 50% = 20%; GLS < 16% = 17%) than those without a history of dengue (LVEF < 50% = 7%; GLS < 16% = 8%; P < 0.01 and 0.06, respectively).Conclusions/SignificanceThe findings of this study suggest that a clinical infection by dengue virus could induce myocardial alterations, mainly in men and in the LV, which could be detected by conventional transthoracic echocardiography. Hence, these results highlight a potential role of echocardiography for screening LV dysfunction in participants with a history of dengue infection. Further larger studies are warranted to validate the findings of this study.
Community-based bilingual doula support during labour and birth to improve migrant women’s intrapartum care experiences and emotional well-being–Findings from a randomised controlled trial in Stockholm, Sweden [NCT03461640]
Authors: Schytt Erica , Wahlberg Anna , Eltayb Amani , Tsekhmestruk Nataliia , Small Rhonda , Lindgren Helena 
Published: November 2022

Objectives
To evaluate the effectiveness of community-based bilingual doula (CBD) support for improving the intrapartum care experiences and postnatal wellbeing of migrant women giving birth in Sweden.

Design
Randomised controlled trial.

Setting
Six antenatal care clinics and five hospitals in Stockholm, Sweden.

Participants
164 pregnant Somali-, Arabic-, Polish-, Russian- and Tigrinya-speaking women who could not communicate fluently in Swedish, were ≥18 years and had no contra-indications for vaginal birth.

Intervention
In addition to standard labour support, women were randomised to CBD support (n = 88) or no such support during labour (n = 76). Trained CBDs met with women prior to labour, provided support by telephone after labour had started, then provided emotional, physical and communication support to women throughout labour and birth in hospital, and then met again with women after the birth.

Primary outcomes
Women’s overall ratings of the intrapartum care experiences (key question from the Migrant Friendly Maternity Care Questionnaire) and postnatal wellbeing (mean value of Edinburgh Postnatal Depression Scale) at 6–8 weeks after birth.

Results
In total, 150 women remained to follow-up; 82 women (93.2%) randomised to receive CBD support and 68 women (89.5%) randomised to standard care (SC). Of women allocated CBD support, 60 (73.2%) received support during labour. There were no differences between the groups regarding women’s intrapartum care experiences (very happy with care: CBD 80.2% (n = 65) vs SC 79.1% (n = 53); OR 1.07 CI 95% 0.48–2.40) or emotional wellbeing (EPDS mean value: CBD 4.71 (SD 4.96) vs SC 3.38 (SD 3.58); mean difference 1.33; CI 95% - 0.10–2.75).

Conclusions
Community-based doula support during labour and birth for migrant women neither increased women’s ratings of their care for labour and birth nor their emotional well-being 2 months postpartum compared with receiving standard care only. Further studies on the effectiveness of CBD powered to evaluate obstetric outcomes are needed.

Trial registration
Trial registration at ClinicalTrial.gov NCT03461640 https://www.google.com/search?client=firefox-b-d&q=NCT03461640.
Healthcare professionals’ perceptions and recommendations regarding adolescent vaccinations in Georgia and Tennessee during the COVID-19 pandemic: A qualitative research
Authors: Olusanya Olufunto A. , White Brianna , Malik Fauzia , Hester Kyra A. , Davis Robert L. , Bednarczyk Robert A. , Shaban-Nejad Arash 
Published: November 2022

Introduction
Despite its benefits, HPV vaccine uptake has been historically lower than other recommended adolescent vaccines in the United States (US). While hesitancy and misinformation have threatened vaccinations for many years, the adverse impacts from COVID-19 pandemic on preventive services have been far-reaching.

Objectives
To explore the perceptions and experiences of adolescent healthcare providers regarding routine vaccination services during the COVID-19 pandemic.

Methodology
Between December 2020 and May 2021, in-depth qualitative interviews were conducted via Zoom video conferencing among a purposively selected, diverse group of adolescent healthcare providers (n = 16) within 5 healthcare practices in the US southeastern states of Georgia and Tennessee. Audio recordings were transcribed verbatim and analyzed using a rapid qualitative analysis framework. Our analysis was guided by the grounded theory and inductive approach.

Results
Participants reported that patient-provider communications; effective use of presumptive languaging; provider’s continuing education/training; periodic reminders/recall messages; provider’s personal conviction on vaccine safety/efficacy; early initiation of HPV vaccination series at 9 years; community partnerships with community health navigators/vaccine champions/vaccine advocates; use of standardized forms/prewritten scripts/standard operating protocols for patient-provider interactions; and vaccine promotion through social media, brochures/posters/pamphlets as well as outreaches to schools and churches served as facilitators to adolescent HPV vaccine uptake. Preventive adolescent services were adversely impacted by the COVID-19 pandemic at all practices. Participants highlighted an initial decrease in patients due to the pandemic, while some practices avoided the distribution of vaccine informational materials due to sanitary concerns.

Conclusion
As part of a larger study, we provided contextual information to refine an intervention package currently being developed to improve adolescent preventive care provision in healthcare practices. Our results could inform the implementation of comprehensive intervention strategies that improve HPV vaccination rates. Additionally, lessons learned (e.g. optimizing patient- provider interactions) could be adopted to expand COVID-19 vaccine acceptance on a sizable scale.