bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate effect of lower extremity joint manipulation on a lower extremity somatosensory illusion: a randomized, controlled crossover clinical pilot study
Authors: Schueren Shannon , Hunger Hugh , Pham Huong , Smith Dean L. , Layne Charles , Malaya Christopher A. 
Published: November 2022

Objective:This study explored the influence of lower extremity manipulation on the postural after-effects of standing on an inclined surface.Methods:Eight healthy individuals (28.0 ± 4.1 years) were recruited for this open-label, crossover study. Participants stood on an incline board for 3 min to develop a known form of somatosensory illusion. After randomization to either a lower-extremity joint manipulation or no intervention, participants immediately stood on a force plate for 3 min with eyes closed. After a 24-h washout period, participants completed the remaining condition. Center of pressure (CoP) position data was measured by a force plate and evaluated using statistical parametric mapping. Pathlength, mean velocity, and RMS were calculated for significant time periods and compared with corrected pairedt-tests.Results:Parametric maps revealed that CoP position of control and intervention conditions differed significantly for two time periods (70–86 s—control: 0.17 ± 1.86 cm/intervention: −1.36 ± 1.54 cm; 141–177 s—control: −0.35 ± 1.61 cm/intervention: −1.93 ± 1.48 cm). CoP pathlength was also significantly decreased for the second period (control: 6.11 ± 4.81 cm/intervention: 3.62 ± 1.92 cm).Conclusion:These findings suggest that extremity manipulation may be a useful intervention for populations where CoP stability is an issue. This study contributes to the growing body of evidence that manipulation of the extremities can drive global postural changes, as well as influence standing behavior. Further, it suggests these global changes may be driven by alterations in central integration.Clinical Trial Registration:ClinicalTrials.gov, NCT Number: NCT05226715.
Association between exposure to earthquake in early life and diabetes mellitus incidence in adulthood with the modification of lifestyles: Results from the Kailuan study
Authors: Shui Xinying , Zhao Lei , Li Wenli , Jia Yaning , Liu Ziquan , Li Chen , Yang Xueli , Huang Haoran , Wu Shouling , Chen Shuohua , Gao Jingli , Li Xiaolan , Wang Aitian , Jin Xiaobin , Guo Liqiong , Hou Shike 
Published: November 2022

BackgroundExposure to disasters in early life may induce lifetime health risk, but investigation on earthquake exposure and DM in later life is still limited. The aim of the current study is to evaluate the association between exposure to the Tangshan Earthquake in early life and diabetes mellitus (DM) incidence in adulthood, and explore the modification of lifestyles on DM development.MethodsParticipants who were free of DM at baseline from the Kailuan Study were included in this study. All participants were divided into fetal-exposed, infant-exposed, early childhood-exposed and nonexposed group. The effect of earthquake exposure on DM and modification of lifestyles were examined by multivariable-adjusted Cox proportional hazard model.ResultsThe exposed group had a higher risk of DM than nonexposed group, especially in infant-exposed and early childhood-exposed group, with hazard ratio (HR) of 1.62 [95% confidence intervals (CI), 1.21–2.17] and 1.46 (95% CI, 1.06–1.99), respectively. After stratifying by lifestyles, a significant modification was observed in alcohol consumption.ConclusionExposing to earthquake in early life could increase DM incidence in later life, and alcohol consumption might modify the effect of earthquake exposure on DM development. More attention should be paid on the preventions of DM among adults who exposed to earthquake in their early life.
Effects of strength exercise interventions on activities of daily living, motor performance, and physical activity in children and adolescents with leukemia or non-Hodgkin lymphoma: Results from the randomized controlled ActiveADL Study
Authors: Gaser Dominik , Peters Christiane , Oberhoffer-Fritz Renate , Götte Miriam , Feuchtinger Tobias , Schmid Irene , Haller Bernhard , von Luettichau Irene , Kesting Sabine 
Published: November 2022

ObjectivesPediatric patients with cancer experience impairments in muscle strength and physical activity (PA) that may reduce autonomy during hospitalization. To determine the effects of strength exercise interventions on the accomplishment of activities of daily living (ADLs), motor performance, and PA in children with leukemia or non-Hodgkin lymphoma, we randomly allocated patients (4–18 years) immediately after diagnosis into two exercise groups.MethodsThe intervention group (IG; n = 21) received a specific strength training combined with a standard care exercise program, whereas the control group (CG; n = 20) was provided standard care exercise program without any targeted muscle strengthening. After the baseline visit, participants were followed-up three times until intensive treatment cessation. We assessed physical function limitations using the Activities Scale for Kids© (ASK) and Functional ADL Screen. Secondary outcomes were PA levels using accelerometer and motor performance as measured by MOON-test (motor performance in pediatric oncology-test).ResultsIn both groups, ADL accomplishment had significantly increased (p &lt; 0.05). However, no significant between-group differences for ASK outcome were noted. Motor performance was reduced in all motor abilities.ConclusionsBoth exercise interventions were effective to maintain ADLs and motor performance during intensive treatment. In comparison, regular strength exercise interventions in the course of therapy tended to be more beneficial with regards to muscular explosive and endurance strength.
Radon concentration variations at the Yangyang underground laboratory
Authors: Ha C. , Jeong Y. , Kang W. G. , Kim J. , Kim K. W. , Kim S. K. , Kim Y. D. , Lee H. S. , Lee M. H. , Lee M. J. , Lee Y. J. , Seo K. M. 
Published: November 2022

The concentration of222Rn in the air has been measured in the 700 m-deep Yangyang underground laboratory between October 2004 and May 2022. The average concentrations (spreads) in two experimental areas, called A6 and A5, were measured to be 53.4 Bq/m3(13.9 Bq/m3) and 33.5 Bq/m3(7.9 Bq/m3), respectively. The lower value in the A5 area reflects the presence of better ventilation. The radon concentrations sampled within the two A5 experimental rooms’ air are found to be correlated to the local tunnel temperature outside of the rooms, with correlation coefficientsr= 0.22 andr= 0.70. Therefore, the radon concentrations display a seasonal variation, because the local temperature driven by the overground season influences air ventilation in the experimental areas. A sinusoidal function with a period of 1 year was used to fit the radon concentration data of both underground areas finding a maximum amplitude on August, 31 ± 6 days.
Model construction and validation of airflow velocity attenuation through pear tree canopies
Authors: Zhang Fubin , Sun Hao , Qiu Wei , Lv Xiaolan , Chen Yunfu , Zhao Guozhu 
Published: November 2022

To investigate the airflow velocity attenuation inside pear tree canopies and the factors that influence its effect on air-assisted spraying, the relationship between the resistance of the canopies to airflow and airflow velocity inside the canopies was determined. At the same time, the theoretical model of airflow velocity attenuation in the canopy was constructed, in which the velocity attenuation factor k and the incoming velocity were the model input values, and the airflow velocity in the canopy was the model output value. Then, experimental verification of the theoretical model was completed. The determination test of airflow velocity inside canopies with three leaf area densities revealed that the error range between the established theoretical model and the experimental airflow velocity inside the pear tree canopy was 0.11–1.25 m/s, and the mean size of the model accuracy was 83.4% under various working conditions. The results revealed that the region from a depth of 0 m to 0.3 m inside the canopy was the rapid attenuation area of the airflow and that from 0.3 m to 0.9 m was the low attenuation area. Furthermore, they revealed that high-speed airflow could strongly disturb the outer branches and leaves, greatly changing the windward area of the canopy blades and thus affecting the accuracy of the model. By introducing a dynamic parameter of the canopy leaf windward area for model correction, the R2 of the model was above 0.9. Finally, validation of the model was performed in an air-assisted spraying operation in an orchard. This study can provide a theoretical basis for the regulation of airflow parameters of air-assisted spraying of pear trees.
Factors affecting face mask-wearing behaviors to prevent COVID-19 among Thai people: A binary logistic regression model
Authors: Kaewpan Wonpen , Rojpaisarnkit Kunwadee , Pengpid Supa , Peltzer Karl 
Published: November 2022

ObjectivesFace mask wearing is a standard preventive measure, in addition to handwashing and physical distancing. Individuals may find that wearing a face mask protects their physical health and prevents viral transmission. However, none of the studies in Thailand identified factors associated with face mask-wearing behaviors among Thai people. Therefore, this study aims to determine factors affecting face mask-wearing behaviors to prevent COVID-19.MethodsThis research is analytical survey research. The data used in this study were under the project title “The assessment of psychosocial and behavioral response and compliance to restriction measures to prevent and control COVID-19: A series of the rapid survey.” A total of 6,521 people participated in an online survey by multi-stage sampling. Bivariate logistic regression analysis was used to examine the factors associated with face mask-wearing behaviors.ResultsAfter adjusting for independent variables (i.e., gender, age, education, career, smoking, and comorbidity disease), the bivariate logistic regression analysis revealed that gender, age, and career were statistically significant to the face mask-wearing behaviors (p &lt; 0.05). Level of education, smoking, and comorbidity disease were not statistically significant with face mask-wearing behaviors among Thai people.ConclusionFurther study should explore broader on individual face mask perceptions and wearing in the continuing of COVID-19 across gender, age, and careers to better understand their health behaviors and to inform further policy. In addition, the development of an intervention to promote face mask wearing should target men who age below 30 yrs. and did not work in government services careers as this group of the population was likely not to wear a face mask outside the home.
Self-harm among post-natal mothers in Northwest Ethiopia: Implication for policy and practice
Authors: Tiguh Agumas Eskezia , Wondie Kindu Yinges , Gessesse Dereje Nibret , Tsega Nuhamin Tesfa , Aklil Mastewal Belayneh , Temesgan Wubedle Zelalem , Abegaz Marta Yimam , Anteneh Tazeb Alemu , Tibebu Nebiyu Solomon , Alemu Haymanot Nigatu , Haile Tsion Tadesse , Seyoum Asmra Tesfahun , Mesele Tiruye Tilahun , Yismaw Ayenew Engida , Nenko Goshu , Taye Birhan Tsegaw , Mihret Muhabaw Shumye , Kebede Azmeraw Ambachew 
Published: November 2022

IntroductionSelf-harm is a global public health concern affecting thousands of women. However, it is an under-reported and neglected aspect of maternal health, particularly in developing countries. In Ethiopia, there is a paucity of evidence regarding self-harm, and it is rarely given attention. Therefore, this study aimed to assess the proportion of self-harm and associated factors among postnatal mothers in Gondar city, Northwest Ethiopia.MethodA community-based cross-sectional study was conducted from 1 July, 2021, to 30 August, 2021, in Gondar city. A cluster sampling technique was conducted to select 858 women who gave birth in the last 12 months. The data were collected using a structured questionnaire through face-to-face interviews. The data were entered into EpiData version 4.6 and exported to SPSS 25 for analysis. The multivariable logistic regression analysis was fitted to identify factors associated with the outcome variable. The level of significant association was determined at a p-value of ≤ 0.05.ResultThe proportion of postnatal self-harm was found to be 8.5% (95% CI: 6.7,10.5). Having lower family income (AOR: 2.41, 95% CI: 1.05,5.56), having unplanned pregnancy (AOR: 2.70, 95% CI: 1.53,4.79), experiencing adverse birth outcomes (AOR: 3.11, 95% CI: 1.10,8.83), birth not attended by health provider (AOR: 4.15, 95% CI: 1.76,9.79), experiencing intimate partner violence (AOR: 1.93, 95% CI: 1.12,3.32), and poor decision-making power (AOR: 1.70, 95% CI: 1.02, 2.84) were the variables significantly associated with self-harm.ConclusionThis study revealed that the proportion of self-harm among postnatal mothers was prevalent. Factors like monthly income of a family, planned pregnancy, birth outcome, birth assistant, intimate partner violence, and decision-making power show an association with maternal self-harm. Antenatal and postnatal self-harm screening as part of the continuum of maternal healthcare is important. Self-harm is also a danger for women who have experienced intimate partner violence or have low socioeconomic economic status, all of which require exceptional mental health assessment.
Early return to work: Single-port vs. multiport laparoscopic surgery for benign ovarian tumor
Authors: Tang Ying , Wen Ming-bo , Su Bin , Wang Hang , Zheng Xue-mei , Yang Ming-tao , Yin Shu , Xu Fan , Hu Hui-quan 
Published: November 2022

ObjectiveTo compare the return to work (RTW) time between single-port laparoscopic surgery (SPLS) and multiport laparoscopic surgery (MPLS) for benign ovarian tumors.MethodsA cross-sectional cohort study was conducted, which consisted of 335 women of reproductive age with benign ovarian tumors and who were keen on returning to work as early as possible. Surgical outcomes, postoperative pain score, postoperative satisfaction with the cosmesis score (CS), and the RTW time of the SPLS group were compared with those of the MPLS group. Besides, the RTW time and CS were calculated from the questionnaire survey by a single specialized gynecologist.ResultsWomen who met the inclusion criteria were included in the SPLS (n = 106) and MPLS groups (n = 229). The RTW time in the SPLS group (22.13 ± 27. 06 days) was significantly shorter than that in the MPLS group (46.08 ± 57.86 days) (P &lt; 0.001). The multivariate Cox analysis results showed that age (HR = 0.984, 95% CI, 0.971−0.997, P = 0.020), SPLS (HR = 3.491, 95% CI, 2.422−5. 032, P &lt; 0.001), and return to normal activity time (HR = 0.980, 95% CI, 0.961−0.998, P = 0.029) were independent factors of the RTW time.ConclusionsSPLS may be advantageous in terms of shortening the RTW time for women with benign ovarian tumors.
Four cases report: Treatment of knee joint cartilage defects using autologous chondrocyte patch implantation
Authors: Wang Le , Li Han , Cao Yiguo , Song Cheng , Chen Qi , Hao Jun , Zhang Weiguo , Tian Kang 
Published: November 2022

IntroductionAutologous chondrocyte implantation (ACI) is a crucial method for the treatment of defects in articular cartilage. However, the extant methods for the preparation of autologous chondrocyte patch are relatively complicated and money-consuming. Therefore, an efficient, reliable, easy-to-follow, and cost-effective technique is needed to overcome constraints. This case report aims to introduce an autologous chondrocyte patch fabrication technique to repair knee joint cartilage defects and report our typical cases with a 2-year follow-up.Case presentationWe described four cases in which patients complained of knee joint pain. According to radiological examination, the patients were diagnosed as knee joint cartilage defect. Arthroscopy and autologous chondrocyte patch implantation were performed as well as a 2-year follow up of patients. The autologous chondrocyte patch for knee joint cartilage repair was fabricated using a “sandwich” technique. The preoperative and postoperative knee function was evaluated by four subjective evaluation systems. MRI was performed for all patients to achieve more intuitionistic observation of the postoperative radiological changes of defect sites. The quality of repaired tissue was evaluated by Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART). Postoperative follow-up showed improvement in clinical and MOCART scores for all patients. However, one patient complained of knee joint pain after walking for a long time or recreational activities from 12- to 18-month postoperatively. The location of pain for this patient was not in accordance with the location of cartilage defect.ConclusionThe patients undergoing autologous chondrocyte patch implantation demonstrated clinical improvement and good quality of repaired tissue postoperatively. The procedure is an efficient and cost-effective treatment for knee joint cartilage defect in this report. In addition, patients with osteoarthritis carry the risk of a poor outcome after the procedure, and whether to have a procedure should be considered carefully.
Remifentanil combined with dexmedetomidine on the analgesic effect of breast cancer patients undergoing modified radical mastectomy and the influence of perioperative T lymphocyte subsets
Authors: Zhang Yanjun , Jiang Wei , Luo Xi 
Published: November 2022

ObjectiveTo study the analgesic effect of breast cancer patients undergoing modified radical mastectomy (MRM) and the influence of perioperative T lymphocyte subsets by remifentanil combined with dexmedetomidine.Methods80 breast patients were divided into control group and research group based on the anesthesia protocol. Patients in control group was given remifentanil for anesthesia induction and maintenance, and patients in research group was given remifentanil and dexmedetomidine for anesthesia induction and maintenance. We compared the anesthesia time, operation time, surgical blood loss, postoperative wake-up time, extubation time, incidence of adverse reactions, VAS score and T lymphocyte subsets in peripheral blood in the two groups of patients.ResultsThe baseline data including age, height, weight and BMI, ASA classification, stage of breast cancer, frequency of neoadjuvant therapy, and surgical characteristics including anesthesia time, operation time and bleeding volume all have no significant difference between two groups (P &gt; 0.05). Compared to control group, the time of wake up and extubation in patients of research group were all significantly decreased (P &lt; 0.05), and significantly decreased MBP and HR after loading dose of dexmedetomidine in research group (P &lt; 0.05). The VAS scores of patients at 4, 8, 12, 16, 20 and 24 h after surgery in the research group are all significantly lower than those in the control group (P &lt; 0.05). Before induction of anesthesia, there was no significant difference in the ratio of CD4+, CD8+ and CD4+/CD8+ T lymphocytes in peripheral blood between the two groups (P &gt; 0.05). At 1 h during operation and 24 h after operation, the ratio of CD4+ and CD4+/CD8+ cells in the research group was significantly higher than these of the control group (P &lt; 0.05), while the ratio of CD8+ cells was lower than that of the control group (P &lt; 0.05).ConclusionFor breast cancer patients undergoing MRM, the use of remifentanil combined with dexmedetomidine can enhance postoperative analgesia and reduce postoperative immunosuppression.
Predictive role of the neutrophil: lymphocyte ratio in acute kidney injury associated with off-pump coronary artery bypass grafting
Authors: Yu Ruiming , Song Han , Bi Yanwen , Meng Xiangbin 
Published: November 2022

ObjectivesThis study aims to investigate whether the ratios of cell types in peripheral blood could be used as reliable predictors of off-pump coronary artery bypass grafting (CABG)-associated acute kidney injury (AKI).Materials and methodsWe retrospectively reviewed patients (n = 420) undergoing off-pump CABG from January 1, 2021 to January 1, 2022 in Qilu Hospital of Shandong University. We used logistic regression analysis to identify the potential predictors of off-pump CABG-associated AKI and construct a predictive model. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive ability of predictors and prediction models.ResultsThe prevalence of AKI associated with off-pump CABG was 20.95%. Patients in the AKI group had significantly higher ratios of peripheral blood cells on postoperative day (POD)1 than patients in the non-AKI group (P &lt; 0.01). The area under the ROC curve (AUC) of the neutrophil:lymphocyte ratio (NLR) on POD1 for predicting off-pump CABG-associated AKI was 0.780 and the cutoff value was 20.07. Patients with high NLR on POD1 had a poor short-term prognosis. The AUC of the predictive model constructed by logistic regression analysis was 0.882. The sensitivity was 68.2% and the specificity was 93.1%.ConclusionThe NLR on POD1 was a reliable predictive biomarker of off-pump CABG-associated AKI. And we successfully construct a prediction model, which contribute to the early recognition and management of off-pump CABG-associated AKI.
FOXC2 as a prognostic marker and a potential molecular target in patients with human solid tumors
Authors: Zhang Long , He Yong , Tu Xiaohong , Wang Chao , Ding Xiaojun , Ye Rongqiang , Shi Jiayu , Xie Yuancai , Jiang Yufen , Deng Xiaohong 
Published: November 2022

BackgroundForkhead Box Protein C2 (FOXC2) belongs to the Forkhead/Wing-helix family. The regulatory role of this transcription factor in physiological function and carcinogenic activity has been proven in subsequent investigations. However, there is still scarcity of evidence on the relationship between FOXC2 expression and prognosis in human solid tumors. We conducted this meta-analysis to evaluate the role of FOXC2 as a prognosis factor and a possible target marker in human solid tumors.MethodsPubMed, Web of Science, Embase, and the Cochrane library database were all searched methodically. Eligible publications on FOXC2 in human solid tumors were gathered and reviewed. The effect sizes were calculated using pooled hazard ratios (HRs) or odds ratios (ORs) with the corresponding 95% confidence interval (CI). Statistical analysis was conducted with Stata SE12.0.ResultsThis meta-analysis comprised 3,267 patients from 20 studies covering a variety of solid tumors. Increased FOXC2 expression was related to shorter overall survival (OS) (HR = 2.05, 95% CI: 1.73–2.42). High expression of FOXC2 is associated with lymph node metastases (OR = 3.33, 95% CI: 2.65–4.19), TNM stage (OR = 3.09, 95% CI: 2.00–4.78), and age (OR = 1.26, 95% CI: 1.06–1.50), according to the pooled ORs. However, no significant association was observed between the high expression of FOXC2 and sex, tumor size or tumor differentiation.ConclusionIncreased expression of FOXC2 is associated with unfavored OS, lymph node metastases, TNM stage, and age. FOXC2 is a promising prognostic marker and a novel target marker in human solid tumors.
Some New Integral Inequalities for Generalized Preinvex Functions in Interval-Valued Settings
Authors: Khan Muhammad Bilal , Macías-Díaz Jorge E. , Soliman Mohamed S. , Noor Muhammad Aslam 
Published: November 2022

In recent years, there has been a significant amount of research on the extension of convex functions which are known as preinvex functions. In this paper, we have used this approach to generalize the preinvex interval-valued function in terms of (£1, £2)-preinvex interval-valued functions because of its extraordinary applications in both pure and applied mathematics. The idea of (£1, £2)-preinvex interval-valued functions is explained in this work. By using the Riemann integral operator, we obtain Hermite-Hadamard and Fejér-type inequalities for (£1, £2)-preinvex interval-valued functions. To discuss the validity of our main results, we provide non-trivial examples. Some exceptional cases have been discussed that can be seen as applications of main outcomes.