bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Labor Movement Strike Violence, the Press, and the Upton Sinclair Hypothesis
Authors: Isaac Larry W. , Coley Jonathan S. , Ingersoll Hannah 
Published: October 2022

Abstract
During the labor movement’s formative years, Upton Sinclair was among the most vehement critics of the press for, as he claimed, a wide variety of “capitalist corruptions.” The authors examine one of Sinclair’s central charges in his The Brass Check, the first major book-length criticism of the U.S. corporate press: When strikers are violent, they get reported on the wire services; when they are not violent, they are ignored by the wires and thus the papers. This press selection process serves to create in public consciousness a strong association between strikes and violence. Focusing on coverage by the New York Sun and New York Times for fourteen major strikes spanning the Gilded Age and Progressive Era, evidence suggests that Sinclair’s claim was, with some qualification, generally correct. The authors discuss implications of negative press as “soft repression” during the formative years of the labor movement and prior to journalism’s major moves at professionalization.
Quantifying Flood Frequency Associated with Clustered Mesoscale Convective Systems in the United States
Authors: Hu Huancui , Feng Zhe , Leung L. Ruby 
Published: October 2022

Abstract
Mesoscale convective systems (MCSs) that are clustered in time and space can have a broader impact on flooding because they have larger area coverage than that of individual MCSs. The goal of this study is to understand the flood likelihood associated with MCS clusters. To achieve this, floods in the Storm Events Database in April–August of 2007–17 are matched with clustered MCSs identified from a high-resolution MCS dataset and terrestrial conditions in a land surface dataset over the central-eastern United States. Our analysis indicates that clustered MCSs preferentially occurring in April–June are more effective at producing floods, which also last longer due to the greater rainfall per area and wetter initial soil conditions and, hence, produce greater runoff per area than nonclustered MCSs. Similar increases of flood occurrence with cluster-total rainfall size and wetter soils are also observed for each MCS cluster, especially for the overlapping rainfall areas within each cluster. These areas receive rainfall from multiple MCSs that progressively wet the soils and are therefore associated with higher flood likelihood. This study underscores the importance to understand clustered MCSs to better understand flood risks and their future changes.
Check the Balance: Is the Doctrine of Separation of Powers Sufficient in the Context of Intergovernmental Organisations? A Case Study of Australia’s AML/CTF Financing Framework
Authors: Goldbarsht Doron , Harris Hannah 
Published: October 2022

AbstractThis article demonstrates the pressing need to rethink the doctrine of separation of powers in Australia in light of the increasing influence of intergovernmental organisations such as the Financial Action Task Force (‘FATF’), which are shaping domestic lawmaking. The article documents the influence of the FATF on Australia’s anti-money laundering and counter-terrorism financing framework, showing how FATF ‘recommendations’ are in fact decrees that Australia and other nation states integrate into their domestic legal systems — even when the legislative branch of government does not support such actions. The article suggests that Australia should consider implementing a fourth arm of government — an integrity arm — to strengthen the nation against the influence of intergovernmental organisations.
Who is a Journalist? A Critical Analysis of Australian Statutory Definitions
Authors: Ananian-Welsh Rebecca 
Published: October 2022

AbstractThis article provides the first comprehensive study of statutory definitions of ‘journalist’ and ‘journalism' in Australian law and proposes a preferred definition of journalist by reference to statutory aims, bedrock legal principles and broader scholarship. It begins with a review of existing literature on the meaning of ‘journalist' in the modern media landscape, before turning to Australian law. A qualitative survey of legislation identified 11 textually different definitions of the term ‘journalist’ across 18 separate statutes, and a single definition of ‘journalism’. Examination of the statutory contexts, purposes and framing of these definitions reveals they are comprised, broadly, of six ‘approaches’. These approaches are critically analysed against a novel five-part thematic framework, with particular attention given to whether journalists should be defined by reference to ethical codes and responsibilities. The article concludes by identifying a preferred definition of journalist capable of informing law reform across a wide-variety of areas of law, including protections for press freedom, journalistic access to information, shield laws and whistleblower protections.
Endovascular solutions for abdominal aortic aneurysms: A comparative review of clinical outcomes with custom-made endografts
Authors: Jubouri Matti , Hussain Kamran , Saha Priyanshu , Alkhadire Zaid M , Tan Sven ZCP , Bailey Damian M , Williams Ian M , Bashir Mohamad 
Published: October 2022

Background The introduction of endovascular aortic repair has revolutionised the treatment of abdominal aortic aneurysms, replacing open surgical repair for the majority of elective cases due to its optimal morbidity and mortality. Several endovascular aortic repair stent grafts exist commercially, one of which is the Fenestrated Anaconda™ by Terumo Aortic which benefits from a very innovative design, unique custom-made approach and highly favourable results. Aims The main scope of this narrative review is to provide a comprehensive overview of endovascular aortic repair clinical outcomes using the Fenestrated Anaconda™ stent-graft and comparing these with its market competitor, Zenith. This review will also examine the evidence in the literature on the Anaconda™'s custom-made approach. Methods A comprehensive literature was conducted on several search engines including PubMed, Google Scholar, Ovid, Scopus and Embase to collate the evidence in the literature on clinical outcomes achieved with the Fenestrated Anaconda™ and Zenith including, but not limited to, survival, technical success, target vessel patency, endoleak, reintervention and aneurysm sac regression. Results The Fenestrated Anaconda™ is associated with excellent results, including highly favourable survival, technical and clinical success and target vessel patency rates, very low need for reintervention or conversion, and minimal incidence of complications such as endoleak and endograft migration. The Fenestrated Anaconda™ also drives significant sac regression and aortic remodelling. In addition, its unique custom-made approach enables it to treat highly complex aortic anatomy as well as to ‘rescue’ failed competitor grafts. Conclusion The Fenestrated Anaconda™ has proven that it is a very safe, highly applicable and extremely effective device used for complex aortic and/or iliac pathology based on its novel design and outstanding track record of clinical outcomes.
Integrated Analysis of Multi-Omics Data to Establish a Hypoxia-Related Prognostic Model in Osteosarcoma
Authors: Tong Ye , Zhang Xiaoqing , Zhou Ye 
Published: October 2022

Background: Osteosarcoma (OS) is the most common malignant bone tumor in clinical practice, and currently, the ability to predict prognosis in the diagnosis of OS is limited. There is an urgent need to find new diagnostic methods and treatment strategies for OS. Material and methods: We downloaded the multi-omics data for OS from the TARGET database. Prognosis-associated methylation sites were used to identify clustered subtypes of OS, and OS was classified into 3 subtypes (C1, C2, C3). Survival analysis showed significant differences between the C3 subtype and the other subtypes. Subsequently, differentially expressed genes (DEGs) across subtypes were screened and subjected to pathway enrichment analysis. Results: A total of 249 DEGs were screened from C3 subtype to other subtypes. Metabolic pathway enrichment analysis showed that DEGs were significantly enriched to the hypoxic pathway. Based on univariate and multivariate COX regression analysis, 12 genes from the hypoxia pathway were further screened and used to construct hypoxia-related prognostic model (HRPM). External validation of the HRPM was performed on the GSE21257 dataset. Finally, differences in survival and immune infiltration between high and low risk score groups were compared. Conclusion: In summary, we proposed a hypoxia-associated risk model based on a 12-gene expression signature, which is potentially valuable for prognostic diagnosis of patients with OS.
Do adoption age and country of origin matter for non-kin adoptees’ risk of psychiatric contact and post-adoption out-of-home care placement?
Authors: Olsen Rikke F. 
Published: October 2022

Aim: The aim of this study was to investigate within-group differences among Danish non-kin adoptees with regard to probability of mental health problems and post-adoption out-of-home care (OHC) placement, with a particular focus on whether adoption age and country of origin mattered. Methods: I used Danish registry data on non-kin adoptees born between 1989 and 1994 ( N=2922) at the age of 17 and applied bivariate analyses and seemingly unrelated regression to describe associations between non-kin adoptees’ adoption characteristics and two outcomes: (a) psychiatric contact and (b) post-adoption OHC. Results: Psychiatric contact and post-adoption OHC co-occurred among non-kin adoptees, and these two life events should be considered jointly. Adoption age mattered equally for the risk of psychiatric contact and OHC, but country of origin mattered more for psychiatric contact than for OHC. Adoption at one year of age and older was associated with an elevated risk of psychiatric contact and OHC. Romanian adoptees had a higher likelihood of psychiatric contact when compared to all the other adoptees, regardless of country of origin. In contrast, adoptees from India had a lower probability of psychiatric contact and of entering OHC compared to all the other adoptees. Conclusions: The heterogeneity in non-kin adoptees’ psychiatric contact and OHC in terms of adoption age and country of origin is important to consider in future research, as well as for social workers and clinicians in their role of promoting health and preventing mental health problems.
Real-world treatment patterns and outcomes among patients with advanced non-small-cell lung cancer with spindle cell and/or giant cell carcinoma
Authors: Chang Chia-Ling , Hsieh Min-Shu , Shih Jin-Yuan , Lee Yi-Hsuan , Liao Wei-Yu , Hsu Chia-Lin , Yang Ching-Yao , Chen Kuan-Yu , Lee Jih-Hsiang , Ho Chao-Chi , Tsai Tzu-Hsiu , Yang James Chih-Hsin , Yu Chong-Jen 
Published: October 2022

Objectives: A definitive diagnosis of pulmonary sarcomatoid carcinoma cannot be made with small biopsies. In clinical practice, a diagnosis of advanced non-small-cell lung cancer with spindle cell and/or giant cell carcinoma (NSCLCsg), or possible sarcomatoid carcinoma, is acceptable. Therefore, we aimed to investigate the treatment patterns and outcomes of advanced NSCLCsg. Materials and methods: Between 01 January 2012 and 01 April 2021, patients with pathologically proven advanced NSCLCsg were enrolled. The choice of treatment was based on clinician discretion. Results: In all, 101 patients with advanced NSCLCsg were enrolled. In total, 77 (76.2%) patients received at least one line of systemic therapy; 44 patients (43.1%) had received platinum doublet chemotherapy; 27 (26.7%) patients had been treated with targeted therapies; and 23 patients (22.8%) had been given an immune checkpoint inhibitor (ICI). The median overall survival (OS) was 6.3 months [95% confidence interval (CI): 3.6–9.0 months]. Excluding patients without systemic therapy, patients who had received an ICI had better OS (median: 18.2 months) than those who had not (median 3.8 months, log-rank test p = 0.002). No significant difference in OS was detected between patients who had or had not received platinum doublet chemotherapy (log-rank test p = 0.279), or targeted therapy (log-rank test p = 0.416). Having received any systemic therapy [hazard ratio (HR): 0.33, 95% CI: 0.18–0.61, p < 0.0001) and ICI (HR: 0.38, 95% CI: 0.19–0.78, p = 0.008) were independent factors for better OS. Patients with programmed death ligand-1 (PD-L1) expression ⩾50% had better OS than those with PD-L1 expression <50% (HR: 0.51, 95%: 0.30–0.86, p = 0.012). Conclusion: Although advanced NSCLCsg has a poor survival outcome, our results showed that ICI may prolong OS in patients with advanced NSCLCsg. Further prospective studies are warranted to gain more understanding of the role of ICI in this specific patient population.
Big data and ICT solutions in the European Union and in China: A comparative analysis of policies in personalized medicine
Authors: Causio Francesco Andrea , Hoxhaj Ilda , Beccia Flavia , Marcantonio Marzia di , Strohäker Timo , Cadeddu Chiara , Ricciardi Walter , Boccia Stefania 
Published: October 2022

Introduction Several countries are either planning or implementing national strategies for the development and integration of Personalized Medicine (PM) into their healthcare systems. Personalized Medicine is an undisputed priority of the European Commission (EC), which has funded the project “Integrating China into the International Consortium for Personalized Medicine” (IC2PerMed), in order to ensure a common basis for Sino-European collaborations. By mapping the current PM landscape in the European Union (EU) and in China, IC2PerMed aims to provide key solutions toward a synergistic and coordinated approach in the field of PM. Methods An extensive desk research was conducted, aimed at identifying documents on PM-related policies, programs, and action plans in the EU and in China, published up to November 2020. The search was conducted by exploring scientific and gray literature, and official institutional repositories. A descriptive summary condensed the information retrieved for both. Results Since 2013, the year of publication of the first PM policy by the EC “Use of omics technologies in PM development,” several documents have been published. PM is a key element of the policy agenda also in China, which in 2016 integrated PM into the 13th National Five-Year Plan, followed by the publication of several policies on technology infrastructure and big data. Both in the EU and China, especially in recent years, these policies addressed in detail the issues of big data, data interoperability and exchange, while defining the standards of information and communication infrastructures. Conclusions In order to allow optimal collaboration, it is essential to understand similarities and differences between the respective policy strategies, with particular attention to data management and adopted infrastructures. The results of this project may enable the development of joint Sino-European research and innovation initiatives, promoting developments in the field of PM.
Photobiomodulation for modulation of neuropathic pain and improvement of scar tissue
Authors: Santiago Ronaldo , Gomes Shannon , Ozsarfati Jak , Zitney Michael 
Published: October 2022

Background This case-report explores the effects of photobiomodulation therapy (PBMT) on the healing of scar tissue. The patient was a 32-year old female two years post cholecystectomy resulting in a 15 cm linear scar that was causing severe pain. Methods Treatment was initiated using the BIOFLEX® therapist device which consists of LED arrays and laser probes of a specific wavelength, power and frequency applied directly on the skin overlying the scar. The frequency and duration of treatment was every other day for six weeks in a clinic setting, followed by three times a week for two months at home. Then the patient continued to use the BIOFLEX® therapist home device on an as-needed basis. Findings The final result of this patient's treatment was significant flattening and decreased redness of her scar. Her self-reported pain decreased to a 6/10. At the one year follow up, the patient reported that she stopped taking her opioids, antidepressant and sleeping pills and that her pain decreased to a 4/10. At the last review her pain score was 1/10; and she had returned to work and took Tylenol (acetaminophen) occasionally for breakthrough pain. Conclusions We attribute the patient's improvement in scar appearance and pain symptoms to PBMT. Since pain is often associated with depressed mood and sleep disturbances, it cannot be determined whether PBMT was the direct or indirect cause of this patient's improved mood. For future studies, we propose the use of control subjects with similar scars treated with sham treatment compared to those who will receive the PBMT and observed for the same duration of time and compare the overall results. Lay Summary Dermatological applications, especially wound healing; are accepted indications for photobiomodulation therapy (PBMT). The expansion into other clinical applications, particularly neurological ones show potential benefit. We present a case of a patient with a hypertrophic scar associated with severe neuropathic pain and concurrent depression, all of which improved directly or indirectly with PBMT. Although the original focus of treatment was dermatological the improvement in pain plus the discontinuation of therapy (opioids, antidepressants and benzodiazepines) were considered to be due to the PBMT.
The Adverse and Advantage Effects of Wearing a Facemask in Thai Children: A Survey During the COVID-19 Pandemic
Authors: Ratchatavech Kritchawan , Techasatian Leelawadee , Panombualert Sunee , Uppala Rattapon 
Published: October 2022

Background: There is little information on facemask use during the COVID-19 pandemic in the pediatric population. This became the main purpose of the present study to investigate demographic data of facemask wearing in children, types, and length of facemask, as well as the benefits, drawbacks, and negative consequences of facemask wearing in this population. Methods: A cross-sectional study was conducted using a structured questionnaire sent via Google Forms. Caregivers for consecutive convenience were asked in the survey (parents of children under the age of 18). Results: A total number of 706 children were enrolled. There were 320 boys (45.33%), and 386 girls (54.67%). The children’s ages range between 4 months and 18 years, with a median age of 9 years. A surgical mask (549, 77.76%) was the most frequent type of facemask in the study population, followed by a cloth mask (86, 12.18%). Facemasks have been shown to be beneficial in the pediatric population. When compared to a former time when facemasks were not used routinely, there were considerably fewer respiratory infections, reduced diarrhea symptoms, and a drop in hospital admissions. In 317 cases (44.9%), children were shown to have negative consequences from wearing facemasks. The most prevalent adverse effect observed in the study population was non-cutaneous (respiratory discomfort/breathing difficulty) which were found in 240 cases (33.99%). Double masking method (surgical + surgical) and wearing a facemask oversize revealed a higher risk in the presence of facemask adverse effects, whereas wearing a proper size facemask reduces the risk of adverse effects from facemask use in children (Adjusted OR [95% CI] = 0.55 [0.38-0.78], P .0003). Conclusions: Wearing a proper-size facemask reduces the risk of adverse effects from facemask use in children. The future suggestion of an appropriate facemask size for a certain age will aid in the avoidance of facemask adverse effects in the pediatric population.
Treatment of Post-Coarctectomy Hypertension With Labetalol—A 9-Year Single-Center Experience
Authors: Siersma Carolien , Brouwer Carole N. M. , Sojak Vladimir , Ten Harkel Arend D. J. , Roeleveld Peter P. 
Published: October 2022

Background Although considering the pathophysiology of post-coarctectomy hypertension, β-blockers should be effective, experience with labetalol for treatment is limited in the literature. Methods Retrospective collection and analysis of data in children aged ≤6 years following coarctectomy in our tertiary care university medical center between January 2009 and June 2018. Results 96 patients were included, 45 were treated with intravenous labetalol and 51 received no treatment. Median time to maximum dose received (median 1.1 mg/kg/h) was 2.7 h, and median time to the reduction of labetalol dose was 8.3 h. No antihypertensives had to be added. In one child, labetalol was switched to nitroprusside due to bronchoconstriction. Of patients receiving intravenous labetalol, 48% had been switched to oral labetalol at discharge. Conclusions Intravenous labetalol is a fast, effective, and safe drug to treat hypertension following aortic coarctation repair. Labetalol is easily converted to oral therapy when the continuation of treatment is considered necessary.
Occlusion Pressure of the Thoracic Duct in Fontan Patients With Lymphatic Failure: Does Dilatation Challenge Contractility?
Authors: Savla Jill J. , Kelly Benjamin , Krogh Emil , Smith Christopher L. , Krishnamurthy Ganesh , Glatz Andrew C. , DeWitt Aaron G. , Pinto Erin M. , Ravishankar Chitra , Gillespie Matthew J. , O’Byrne Michael L. , Escobar Fernando A. , Rome Jonathan J. , Hjortdal Vibeke , Dori Yoav 
Published: October 2022

Background The Fontan circulation challenges the lymphatic system. Increasing production of lymphatic fluid and impeding lymphatic return, increased venous pressure may cause lymphatic dilatation and decrease lymphatic contractility. In-vitro studies have reported a lymphatic diameter-tension curve, with increasing passive stretch affecting the intrinsic contractile properties of each thoracic duct segment. We aimed to describe thoracic duct occlusion pressure and asses if thoracic duct dilation impairs contractility in individuals with a Fontan circulation and lymphatic failure. Methods Central venous pressure and thoracic duct measurements were retrospectively collected from 31 individuals with a Fontan circulation. Thoracic duct occlusion pressure was assessed during a period of external manual compression and used as an indicator of lymphatic vessel contractility. Measurements of pressure were correlated with measurements of the thoracic duct diameter in images obtained by dynamic contrast-enhanced MR lymphangiography. Results The average central venous pressure and average pressure of the thoracic duct were 17 mm Hg. During manual occlusion, the thoracic duct pressure significantly increased to 32 mm Hg. The average thoracic duct diameter was 3.3 mm. Thoracic duct diameter correlated closely with the central venous pressure. The rise in pressure following manual occlusion showed an inverse correlation with the diameter of the thoracic duct. Conclusion Higher central venous pressures are associated with increasing diameters of the thoracic duct. When challenged by manual occlusion, dilated thoracic ducts display a decreased ability to increase pressure. Dilatation and a resulting decreased contractility may partly explain the challenged lymphatic system in individuals with a Fontan circulation.