bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Multidimensional Pain Questionnaire in Professional Dance (MPQDA): a pilot study
Authors: Haenel Jasmin , Schoettker-Koeniger Thomas , Wanke Eileen M. 
Published: November 2022

AbstractBackgroundPain is part of the everyday life of professional dancers. It can indicate health risks and impair the ability to work. Suitable screening tools can be used to identify pain and its risk potential. A comprehensive, multidimensional, differentiated assessment tool for pain in professional dance does not currently exist.MethodsAn initial questionnaire was developed in German and English and was assessed in a qualitative pretest. In a field study with a cross-sectional design including n = 72 dancers from Germany (n = 36 responses each in the English and German language versions), the questionnaire was optimized by item analysis, its psychometric properties (dimensionality, construct validity, reliability) were examined and the ability of the pain dimensions to classify the subjective ability to work in training was analyzed (ROC analysis).ResultsThe developedMultidimensional Pain Questionnaire in Professional Dance(MPQDA) was reduced and optimized in its psychometric properties. Following questions were reduced in their items or answer categories: pain localizations (from 20 to 15 regions), accompanying symptoms (from 6 to 3 items), sensory and affective pain quality (from 20 to 10 items), pain frequency (from 4 to 3 answer categories), and the motives of working with pain (from 14 to 12 items). Regarding the subjective ability to work in training, the variables of the ability to work in rehearsals and in performances, as well as the accompanying symptoms of tension and mobility restrictions, showed a relatively good classification ability (Area under the Curve (AUC) ≥ 0.7 in the 95% confidence interval) and significant, moderate to strong correlations (Somers' D > 0.25,p < 0.05). The classification ability of the other pain dimensions was largely absent or poor.ConclusionThe MPQDA differentiates various pain dimensions in professional dancers and is available in a compatible manner in German and English. The clinical relevance needs to be explored further in the future.
Complete response to nivolumab in Kirsten rat sarcoma virus oncogene KRAS-G12C mutant metastatic lung adenocarcinoma: a case report
Authors: Boby Jeffrey Mathew , Mohd Ghazali Nurul Nadia , Mani Anita , George Mathew 
Published: November 2022

Abstract
Background
The advent of immunotherapies has ushered in a new era in the treatment of non-small cell lung carcinoma. Although immunotherapies are associated with improved clinical outcomes, studies report a median overall survival of 11 months with progression-free survival of 2.5 months with the use of nivolumab for pretreated metastatic non-small cell lung cancer. Herein, we describe a case of advanced non-small cell lung carcinoma that has shown exceptional response to immunotherapy, with the patient being in complete response for the past 6 years since commencement of nivolumab.

Case presentation
We report the case of a 58-year-old female Caucasian, an ex-smoker with 40-pack-year history of smoking, who presented with cough and chest pain and was subsequently diagnosed with metastatic pulmonary adenocarcinoma. The tumor was positive for Kirsten rat sarcoma virus oncogene KRAS-G12C mutation and had high programmed death-1 ligand expression. She was commenced on first-line chemotherapy with carboplatin and gemcitabine with disease response, then continued on maintenance pemetrexed. She was then commenced on immunotherapy with nivolumab, with complete response for a total of 6 years. She does not report any adverse events. Currently, she shows no evidence of recurrence of non-small cell lung carcinoma.

Conclusion
The exceptional response to immunotherapy seen in this case may be explained by the presence of Kirsten rat sarcoma virus oncogene mutation, which is associated with enhanced clinical response to programmed death-1 ligand inhibitors. This report emphasizes the urgent need for further studies evaluating the role of Kirsten rat sarcoma virus oncogene mutation in determining the clinical efficacy of immunotherapies. This would enable us to make effective evidence-based clinical interventions in the treatment of non-small cell lung carcinoma.
Generating evidence for diagnosis and therapy of RarE LIVEr disease: the RELIVE Initiative for systematic reviews and meta-analyses
Authors: Fuchs Juri , Murtha-Lemekhova Anastasia , Pfeiffenberger Jan , Fichtner Alexander , Günther Patrick , Halama Niels , Mayer Philipp , Hornuss Daniel , Klotz Rosa , Probst Pascal , Hoffmann Katrin ,   for the RELIVE Initiative
Published: November 2022

Abstract
Background
Rare liver lesions and diseases have seldomly aroused major interest of researchers. For most guidelines, presumably similar clinical conditions are pooled without detailed investigations of singularities that they present.

Main text
A multidisciplinary project aiming to establish evidence-based therapies for rare liver diseases has been founded. A series of systematic reviews and meta-analyses will be the starting point for a structured development of guidelines for rare conditions of the liver affecting pediatric and adult populations. The novel approach will be focusing on case reports and small patient series with distinct rare liver diseases without pooling several presumably acceptably similar conditions. Thus, a vital resource of information will be utilized, which has been largely neglected hitherto.

Conclusion
Highly specific recommendations based on highest available evidence will therefore be developed for specific conditions, advancing the individualized medicine approach for the afflicted patients.
Hankel operators between different doubling Fock spaces
Authors: Chen Jianjun , Xu Guangxia 
Published: November 2022

AbstractIn this paper, we study Hankel operators on the doubling Fock spaces for all possible $1\leq p,q<\infty $
1
≤
p
,
q
<
∞
. We characterize those symbols f for which the Hankel operators $H_{f}$

H
f

and $H_{\bar{f}}$

H

f
¯

are simultaneously bounded or compact from doubling Fock space $F^{p}_{\varphi}$

F
φ
p

to Lebesgue space $L^{q}_{\varphi}$

L
φ
q

, where φ is a nonzero subharmonic function such that $\Delta \varphi \,dA$
Δ
φ

d
A
is a doubling measure.
Shrinkage and mechanical properties of drying oil paints
Authors: Janas Arkadiusz , Mecklenburg Marion F. , Fuster-López Laura , Kozłowski Roman , Kékicheff Patrick , Favier Damien , Andersen Cecil Krarup , Scharff Mikkel , Bratasz Łukasz 
Published: November 2022

Abstract
Understanding how the evolving molecular composition of an oil paint layer on its transition to an aged solid film affects its dimensional change and mechanical properties is fundamental to the assessment of material durability and more broadly risk of degradation of oil paintings. Tensile properties—modulus of elasticity and strain at break—as well as cumulative shrinkage were determined for a selection of oil paints from Mecklenburg’s Paint Reference Collection now after approximately 30 years of drying. The oil paints were found to get stiffer and more brittle with diminishing plastic deformation and increasingly elastic behaviour. For some paints, the increases in stiffness and decreases in the strain at break were dramatic during the late stage of drying. The observations modify the current physical model of paintings in which the mismatch in the response of glue-based ground layer and unrestrained wood or canvas support to variations in relative humidity (RH) has been identified as the worst-case condition for the fracturing of the entire pictorial layer. This study demonstrated that some paints were more brittle than the glue-based ground layer and as a consequence more vulnerable to cracking. The shrinkage of paints due to molecular relocation and/or evaporation of organic medium as they dry and age was measured. This shrinkage can exceed their strain at break and lead to fracturing of the oil paint layer if it is restrained by a dimensionally stable substrate. Consequently, after long-term drying, the cumulative shrinkage can cause oil paints to crack even in absence of fluctuations in RH or temperature. An example of cracking developed in an oil paint layer on the top of an undamaged ground layer in a historic panel painting was made evident by the X-ray microtomography.
3D printed model for triple negative inflammatory breast cancer
Authors: Huang Yu-Hui , Tuttle Todd M. , Hoven Noelle 
Published: November 2022

Abstract
Background
Access to imaging reports and review of the breast imaging directly with a patient with breast cancer helps improve the understanding of disease extent and severity. A 3D printed breast model can further enhance a patient’s understanding and communication with the healthcare team resulting in improved patient comprehension and patient input with reduced treatment decision conflict. Furthermore, 3D printed models can facilitate training of residents and fellows involved in the diagnosis and treatment management of breast cancer.

Case presentation
We present a 3D printed breast tumor model segmented from positron electron tomography/computed tomography and fabricated via desktop vat polymerization as proof of concept for treatment planning for a patient diagnosed with triple negative inflammatory breast carcinoma.

Conclusion
We illustrate benefits and indications for 3D printing in the management of breast cancer and specifically inflammatory breast cancer in this case. Fabrication and implementation of 3D printed models enhances patient’s understanding and communication with the healthcare team regarding their condition, treatment options and anticipated outcomes. It provides personalized treatment planning by examining patient-specific pathology and the anatomic spatial relationships. Furthermore, 3D printed models facilitate medical education for trainees across disciplines involved in the patient’s care.
A Unified Model of Cohort Mortality
Authors: Lleras-Muney Adriana , Moreau Flavien 
Published: November 2022

Abstract
We propose a dynamic production function of population health and mortality from birth onward. Our parsimonious model provides an excellent fit for the mortality and survival curves for primate and human populations since 1816. The model sheds light on the dynamics behind many phenomena documented in the literature. Simple extensions of the model can reproduce (1) the existence and evolution of mortality gradients across socioeconomic statuses documented in the literature, (2) nonmonotonic dynamic effects of in utero shocks, (3) persistent or scarring effects of wars, and (4) mortality displacement after large temporary shocks, such as extreme weather.
The Unequal Impact of the COVID-19 Pandemic on Infant Health
Authors: Torche Florencia , Nobles Jenna 
Published: November 2022

Abstract
The COVID-19 pandemic has taken a large toll on population health and well-being. We examine the consequences of prenatal exposure for infant health, through which the pandemic may have lasting intergenerational effects. We examine multiple pathways by which the pandemic shaped birth outcomes and socioeconomic disparities in these consequences. Analysis of more than 3.5 million birth records in California with universal information on COVID infection among persons giving birth at the time of delivery reveals deep inequalities in infection by education, race/ethnicity, and place-based socioeconomic disadvantage. COVID infection during pregnancy, in turn, predicts a large increase in the probability of preterm birth, by approximately one third. At the population level, a surprising reduction in preterm births during the first months of the pandemic was followed by an increase in preterm births during the surge in COVID infections in the winter of 2021. Whereas the early-pandemic reduction in preterm births benefited primarily highly educated mothers, the increase in preterm births during the winter infection surge was entirely concentrated among mothers with low levels of schooling. The COVID-19 pandemic is expected to exacerbate U.S. inequality in multiple ways. Our findings highlight a particularly enduring pathway: the long-term legacy of prenatal exposure to an unequal pandemic environment.
Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons
Authors: Hummel Devynn , Becks Alexandria , Men Hongsheng , Bryda Elizabeth C. , Glasco Derrick M. , Chandrasekhar Anand 
Published: November 2022

ABSTRACT
In the developing hindbrain, facial branchiomotor (FBM) neurons migrate caudally from rhombomere 4 (r4) to r6 to establish the circuit that drives jaw movements. Although the mechanisms regulating initiation of FBM neuron migration are well defined, those regulating directionality are not. In mutants lacking the Wnt/planar cell polarity (PCP) component Celsr1, many FBM neurons inappropriately migrate rostrally into r3. We hypothesized that Celsr1 normally blocks inappropriate rostral migration of FBM neurons by suppressing chemoattraction towards Wnt5a in r3 and successfully tested this model. First, FBM neurons in Celsr1; Wnt5a double mutant embryos never migrated rostrally, indicating that inappropriate rostral migration in Celsr1 mutants results from Wnt5a-mediated chemoattraction, which is suppressed in wild-type embryos. Second, FBM neurons migrated rostrally toward Wnt5a-coated beads placed in r3 of wild-type hindbrain explants, suggesting that excess Wnt5a chemoattractant can overcome endogenous Celsr1-mediated suppression. Third, rostral migration of FBM neurons was greatly enhanced in Celsr1 mutants overexpressing Wnt5a in r3. These results reveal a novel role for a Wnt/PCP component in regulating neuronal migration through suppression of chemoattraction.
Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells
Authors: van Leeuwen Wessel , Nguyen Dan T. M. , Grond Rianne , Veenendaal Tineke , Rabouille Catherine , Farías Ginny G. 
Published: November 2022

ABSTRACT
Phase separation of components of ER exit sites (ERES) into membraneless compartments, the Sec bodies, occurs in Drosophila cells upon exposure to specific cellular stressors, namely, salt stress and amino acid starvation, and their formation is linked to the early secretory pathway inhibition. Here, we show Sec bodies also form in secretory mammalian cells upon the same stress. These reversible and membraneless structures are positive for ERES components, including both Sec16A and Sec16B isoforms and COPII subunits. We find that Sec16A, but not Sec16B, is a driver for Sec body formation, and that the coalescence of ERES components into Sec bodies occurs by fusion. Finally, we show that the stress-induced coalescence of ERES components into Sec bodies precedes ER exit inhibition, leading to their progressive depletion from ERES that become non-functional. Stress relief causes an immediate dissolution of Sec bodies and the concomitant restoration of ER exit. We propose that the dynamic conversion between ERES and Sec body assembly, driven by Sec16A, regulates protein exit from the ER during stress and upon stress relief in mammalian cells, thus providing a conserved pro-survival mechanism in response to stress.
Tag-based estimates of bottlenose dolphin swimming behavior and energetics
Authors: Gabaldon Joaquin T. , Zhang Ding , Rocho-Levine Julie , Moore Michael J. , van der Hoop Julie , Barton Kira , Shorter K. Alex 
Published: November 2022

ABSTRACT
Current estimates of marine mammal hydrodynamic forces tend to be made using camera-based kinematic data for a limited number of fluke strokes during a prescribed swimming task. In contrast, biologging tag data yield kinematic measurements from thousands of strokes, enabling new insights into swimming behavior and mechanics. However, there have been limited tag-based estimates of mechanical work and power. In this work, we investigated bottlenose dolphin (Tursiops truncatus) swimming behavior using tag-measured kinematics and a hydrodynamic model to estimate propulsive power, work and cost of transport. Movement data were collected from six animals during prescribed straight-line swimming trials to investigate swimming mechanics over a range of sustained speeds (1.9–6.1 m s−1). Propulsive power ranged from 66 W to 3.8 kW over 282 total trials. During the lap trials, the dolphins swam at depths that mitigated wave drag, reducing overall drag throughout these mid- to high-speed tasks. Data were also collected from four individuals during undirected daytime (08:30–18:00 h) swimming to examine how self-selected movement strategies are used to modulate energetic efficiency and effort. Overall, self-selected swimming speeds (individual means ranging from 1.0 to 1.96 m s−1) tended to minimize cost of transport, and were on the lower range of animal-preferred speeds reported in literature. The results indicate that these dolphins moderate propulsive effort and efficiency through a combination of speed and depth regulation. This work provides new insights into dolphin swimming behavior in both prescribed tasks and self-selected swimming, and presents a path forward for continuous estimates of mechanical work and power from wild animals.
Coping methods among Polish students during Covid-19 pandemic
Authors: Kawalec Alicja , Wilczyński Krzysztof Maria , Biecka Adrianna , Krupnik Dominika , Grabowski Wojciech , Janas - Kozik Małgorzata 
Published: November 2022

Cel pracyPandemia Covid-19 drastycznie zmieniła codzienną rzeczywistość i zmusiła całe społeczeństwa do wypracowania nowych metod radzenia sobie ze stresem. Studenci stanowili grupę, której rytm dnia i pracy został drastycznie zmieniony. Przeprowadzona analiza sposobów adaptacji do przewlekłego stresu wraz z oceną ich skuteczności, może pomóc jednostkom i grupom społecznym najbardziej narażonym na stres.MetodaAnaliza metod radzenia sobie ze stresem oraz poziomu agresji została przeprowadzona za pomocą kwestionariuszy Brief COPE i STAXI-2 na grupie 283 uczestników, wyłonionych z grupy 906 osób biorących udział w początkowej fazie badania. Badanie odbyło się pomiędzy drugą i trzecią falą pandemii w Polsce.WynikiW badanej grupie przeważały pozytywne metody radzenia sobie ze stresem, takie jak aktywne działanie, wykorzystanie wsparcia informacyjnego oraz planowanie. Negatywne metody były nieodłącznie związane z wyższym poziomem agresji. Oba te elementy przeważały u kobiet w sposób istotny statystycznie.WnioskiPierwsze sygnały dotyczące patologicznych metod radzenia sobie ze stresem mogą być subtelne i ukryte w potencjalnie zwyczajnych reakcjach na stresujące zdarzenia. Należy być świadomym ich obecności, aby móc zapewniać lepszą pomoc wśród środowisk nie tylko studenckich, a także innych znacząco narażonych na chroniczny stres.
Debiasing the Disposition Effect with Noninvasive Brain Stimulation: The Role of Cognitive Control
Authors: Niu Xiaofei , Li Jianbiao , Li Dahui , Cao Qian 
Published: November 2022

This study tests whether modulating a brain region associated with cognitive control using noninvasive brain stimulation affects the disposition effect. A participant trades stocks in an experimental asset market while their level of cognitive control is exogenously manipulated by applying weak current stimulation to a control-related cortical region. We find that the stimulation significantly affects the participant’s cognitive control and tendency to exhibit the disposition effect. This result is also obtained for financial professionals. We thus provide evidence that cognitive control is important for the disposition effect. This paper was accepted by Bruno Biais, finance. Funding: X. Niu acknowledges financial support from the National Natural Science Foundation of China [Grant 72203132], Taishan Scholar Program of Shandong Province [Grant tsqn201909013], and Natural Science Foundation of Shandong Province [Grant ZR2022QG048]. J. Li acknowledges financial support from the National Social Science Foundation of China [Grant 20AZD044], Natural Science Foundation of Shandong Province [Grant ZR2022MG068], and Project of Humanities and Social Sciences of Shandong University [Grant 21RWZD15]. Q. Cao acknowledges financial support from the Social Science Foundation of Jiangsu Province [Grant 21GLC006]. The authors also acknowledge financial support from the Major Project of the National Natural Science Foundation of China [Grant 72192842]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4596 .
“OCUPA CAIRU”: DEMANDAS DE GÊNERO E RAÇA CONSTITUIDAS NA LUTA DO MOVIMENTO DE OCUPAÇÕES DE ESCOLA
Authors: Santos Mariana Dos Reis 
Published: November 2022

O presente estudo baseia-se numa pesquisa que investigou a constituição das demandas e subjetivações de ocupantes de escola pertencentes a instituição “ Visconde de Cairu” (Ocupa Cairu), referentes ao debate de gênero, raça, classe e sexualidade presentes neste espaço cotidiano do movimento. A metodologia empírica utilizada consistiu na análise de entrevistas semiestruturadas durante o ano de 2016, momento da eclosão do movimento de ocupações de escola no estado do Rio de Janeiro. A noção conceitual pós estruturalista de Laclau (2016) foi utilizada, norteando as interpretações das entrevistas destes atores sociais. Também referenciamos as análises das subjetivações destas entrevistas embasando-as teoricamente através de autores do campo da Diversidade tais como: Souza( 1986), Sepulveda e Sepulveda (2016) e Gomes( 2017).A pesquisa evidenciou que embora as demandas iniciais tenham sido de natureza curricular e educacional, outras demandas da “ordem dos desejos” foram enunciadas, como analisamos nas construções discursivas apresentadas por estudantes do gênero feminino no artigo.Com isso, a luta política das ocupações de escola e sua dinâmica de organização dialógica e plural possibilitaram a estes educandos, o questionamentos a papeis de gênero na sociedade, ao disciplinamento dos corpos no ambiente escolar e a identificação com movimentos de mulheres e lgbt.
Allison, Graham. A Caminho da Guerra. Os Estados Unidos e a China conseguirão escapar da Armadilha de Tucídides?. Tradução Cássio Arantes Leite. 2020. Rio de Janeiro: Editora Intrínseca. 1ª Edição, 416p. ISBN: 9786555600346.
Authors: Silva Marcos Valle Machado da 
Published: November 2022

Graham Allison analisa as relações entre a República Popular da China e os Estados Unidos da América (EUA), neste início do século XXI. Dialogando com o passado e trabalhando com cenários prospectivos, Allison apresenta possíveis desdobramentos da ascensão da China vis-à-vis com a reação dos EUA e, assim, descortina para o leitor a necessidade de as duas potências deste início de século evitarem a Armadilha de Tucídides e um potencial conflito militar.Palavras-chave: República Popular da China. Estados Unidos da América. Armadilha de Tucídides.ABSTRACTGraham Allison analyzes the relations between the People's Republic of China and the United States of America (USA) at the beginning of the 21st Century. Dialoguing with the past and working with future scenarios, Allison presents possible consequences of the rise of China vis-à-vis the US reaction and, thus, reveals to the reader the need for the two powers to avoid the Thucydides's Trap and a potential military conflict.Key words: People's Republic of China. United States of America. Thucydides's Trap. Recebido em: 09 mai. 2022 | Aceito em: 15 ago. 2022.