bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEDIA PEMBELAJARAN INTERAKTIF KULTUR JARINGAN TUMBUHAN DI SMA N 1 GRABAG DENGANADOBE ANIMATE CC 2015
Authors: Pambayun Estu Tunjung , Sutiyatno Sukris , Santoso Kartika Imam 
Published: July 2022

The purpose of this research is to be able to design and build multimedia-based learning media in Biology lessons in plant tissue culture material so that it can be used as a learning tool to know more about plant tissue culture material using learning media.From these problems, the idea arose to create Biology Interactive Learning Media on Plant Tissue Culture Materials at SMA Negeri 1 Grabag.The research methodology used in this research is MDLC (Multimedia Development Life Cycle). The modeling used in this design is UML (Unified Modeling Language). System testing in this study uses Black Box Testing for testing application functional requirements, questionnaires for application testing, and Pre-Test Post-Test for material testing.Biology interactive learning media on plant tissue culture material has succeeded in becoming an interesting, effective, efficient source of student learning, as evidenced by the Pre-Test evaluation, there are still many students who have score below the KKM (70). After the Post-Test the student's score increases and it becomes above the KKM. Keywords:Biology, Plant Tissue Culture, MDLC, UML, Interactive
Tantangan Fenomena Keamanan Informasi Pasca Era Revolusi Industri 5.0
Authors: Yusnanto Tri , Mustofa Khoirul , Machmudi Moch Ali , Wahyudiono Sugeng 
Published: July 2022

Pada saat ini sebuah Kemanan Sistem Informasi meruakan yang sangat menarik untuk diulas yang berkaitan dengan berkembangya teknologi pada diera saat ini dan nilai kegunaanya, pada makalah ini akan membahas tentang bentuk ancaman keamanan informasi terhadap sistem keamanan informasi di era pasca revolusi industry 5.0, ini merupakan pondasi kita dalam keamanan informasi denganmemahami beberapa fenomena serta tren perkembang pengunaan internet, mempelajari keterkaitan beberapa ancaman keamanan informasi pasca revolusi industry 5.0, pentingnya keamanan informasi berdasarkan paradikma aksiologi sebagai dasra berfikir untuk penerapan sistem keamanan informasi pada pasca revolusi industri 5.0, peper ini berisikan beberapa saran terhadap arah perkembangan keilmuan keamanan informasi dalam menghadapi era pasca revolusi industri 5.0 berdasar dari filsafat ilmu serta cara menerapkan sistem keamanan informasi yang berdasan teknologi informasi dan keilmuan..Kata kunci : Keamanan Informasi, Ancaman Keamanan, , Pasca Revolusi Industri 5.0, Teknologi.
Rancang Bangun Sistem Informasi Akademik Berbasis Website Di SMP Negeri 1 Kaloran Temanggung
Authors: Priyoatmoko Wahyu , Kapti Kapti 
Published: July 2022

Penelitian ini bertujuan rancang bangun sistem informasi akademik di SMP Negeri 1 Kaloran Temanggung, Metodologi penelitian yang digunakan adalah metode pengembangan dengan Waterfall. Langkah-langkah dari model Waterfall adalah communication (project initiatiation & requirement gathering), planning (estimating, scheduling & tracking), modelling (analisys & design), construction (code & test), deployment (delivery, support & feedback). Perancangan ini menggunakan permodelan Data Flow Diagram(DFD). Aplikasi sistem informasi sekolah berbasis web pada SMP N 1 Kaloran Temanggung merupakan hasil dari penelitian dengan menggunakan pemrograman PHP dan database Mysql.
ANALISIS PENGARUH INVESTASI, SUKU BUNGA KREDIT DAN JUMLAH TENAGA KERJA TERHADAP PRODUKSI INDUSTRI KECIL DAN MENENGAH DI KOTA MAGELANG
Authors: Indrawati Lucia Rita , Togarlaut Lorentino , Sundari Cisilia 
Published: July 2022

Tujuan penelitian ini untuk mengetahui pengaruh investasi, suku bunga kredit dan jumlah tenaga kerja terhadap produksi industri kecil dan menengah. Penelitian ini dilakukan dengan metode kuantitatif. Analisis menggunakan regresi linear berganda. Hasil penelitian menunjukkan bahwa (1) investasi memiliki pengaruh yang tidak signifikan terhadap nilai produksi, (2) suku bunga kredit memiliki pengaruh yang signifikan terhadap nilai produksi, (3) jumlah tenaga kerja tidak memiliki pengaruh yang signifikan terhadap nilai produksi, dan (4) secara bersama-sama investasi, suku bunga kredit, dan jumlah tenaga kerja memiliki pengaruh terhadap nilai produksi.Kata kunci : investasi, suku bunga, tenaga kerja, nilai produksi
Pengaruh Lingkungan Kerja, Disiplin Kerja, dan Motivasi Kerja terhadap Kepuasan Kerja serta Implikasinya pada Kinerja Guru
Authors: Badawi Achmad 
Published: July 2022

The purpose of this study was to obtain empirical evidence and to determine the phenomenon transparently and conclusions about the effect of the work environment, work discipline and motivation on job satisfaction and its implications for teacher performance. The research method using descriptive analysis and verification, with data analysis techniques using Path Analysis. Using probability sampling with proportional stratified cluster random sampling, with a sample size of 248 samples.
The results showed that the working environment conditions that are in both criteria, conditions of work discipline of teachers at both criteria criteria, conditions and motivate the teachers were on good criteria, conditions job satisfaction, are on good criteria, and the condition of teacher performance, are in good criteria. There are later proved significant influence of the working environment to the satisfaction of the Master, There is a significant influence on the discipline of work toward satisfaction, there is a significant effect of work motivation on teacher satisfaction. Simultaneously there is a significant influence of the work environment, work discipline and motivation of teachers to work satisfaction of teachers, with the magnitude of the effect of 69.80 percent, while the influence of other variables outside the model (ε1) amounted to 30.20%. And there is significant influence of satisfaction on the performance of teachers, with the magnitude of the effect of 79.30 percent, while the influence of other variables outside the model (ε2) amounted to 20.70 percent.
Pengaruh Perubahan Lingkungan Usaha dan Karakteristik Kewirausahaan, Terhadap Kinerja dan Pengembangan Usaha Kecil
Authors: Turyandi Itto 
Published: July 2022

The purpose of this study was to determine and assess and analyze the influence of venture capital, changes in business environment, entrepreneurial characteristics on venture performance and the impact on small business development in West Java.
This study uses the approach of human resources management science are combined with theories of organizational behavior. This type of research is descriptive and explanatory verificative survey by research data cross section where the research was conducted at a specific time period with the unit of analysis is a company belonging to the small business sector across the area of ​​West Java Province, with the unit of observation is the manager or industry leaders generally doubles as a small business owner who has received Company Registration issued by the Office of Industry and Commerce of West Java Province. This study data analysis techniques using the structural equation model (structural equation model - SEM).
Results of analysis of this study revealed that 1) the most dominant characteristics of entrepreneurial influence on business performance, 2) changes in business environment is a factor that most small influence on business performance; 3) intangible business capital (education, social, moral and mental) is fundamental aspects to deal with changing business environment, 4) development effort is significantly affected by the performance of the business.
Faktor-Faktor Yang Mempengaruhi Kepuasan Kerja Bidan Dan Implikasinya Terhadap Kinerja Bidan di DKI Jakarta
Authors: Saadah Euis 
Published: July 2022

The purpose of this study was to obtain empirical evidence and conclusions regarding the factors affecting nurse job satisfaction which implicatedto the nurse performance in jakarta.
Methods of data analysis which used to test the hypothesis was path analysis. The independent variable of the study are: the characteristics of nurse (X1), workplace (X2), enabling environments (X3), and access to information (X4), and the dependent variable is nurse job satisfaction(Y).
The results of this study show that: (1) there is a significant effect, either partially or simultaneously from nurse characteristics, work environment, enabling environments, and access to information on nurse job satisfaction in Jakarta, with the amount of influence by 75.59 percent , (2) there is a significant effect of job satisfaction on nurse performance in Jakarta, with the amount of influence at 79.03 percent.
Pengaruh Kerelasian Pelanggan, Kualitas Pelayanan dan Harga terhadap Nilai Pelanggan serta Implikasinya pada Loyalitas Pelanggan
Authors: Kurniawan Pebi 
Published: July 2022

The purpose of this study was to analyze the influence of relations of customer, service quality and price of customer value and customer loyalty, and the influence of relations customer, service quality and price of customer value, also the effect of customer value on customer loyalty. The method used is descriptive and verification with simple technique by using stratifield random sampling on 568 congregation. The data was analyzed using Path analysis techniques (Path Analysis).
The results indicate that: Relations Customer was pretty good towards good, The quality of service was good enough towards good service, The price was quite good towards good, Customer Value was well enough for good, Loyalty Customers good enough towards either there was different significan either partially or simultaneously from the variable of customer relations, service quality and the price of customer Value, there was a strong influence of Customer Value on Customer Loyalty.
The Role of Support From Supervisors and Co-Workers on Financial Service Marketing Agents’ Performance in The Aspects of Work Motivation and Satisfaction
Authors: Abdullatif Rafiqah Saputri , Anindita Rina 
Published: July 2022

The barrier between employees, or the barrier between employees and supervisors in the marketing agency context has been a serious issue that causes detrimental consequences, such as demotivation, degrading productivity, and reduced work performance among employees. The importance of the supervisor and co-worker support has now become a crucial topic, as it is proven to be advantageous for organizations. This research was conducted using questionnaires back in December 2019 until January 2020, in which the respondents consisted of 230 marketing agencies of financial services in DKI Jakarta. The data was analyzed using Structural Equation Model (SEM). There are some significant results in this research. Firstly, there is an association between supervisor support and employee motivation. Secondly, there is an association between co-worker support and work motivation. Next, there is an association between co-worker support and job satisfaction. Fourth, there is an association between work motivation and job satisfaction. Moreover, there is an association between work motivation and employee performance. Lastly, there is an association between job satisfaction and employee performance. However, there is no significant association between supervisor support and job satisfaction.
Exploring the experience of community health workers in COVID-19 pandemic response in Indonesia: A qualitative study
Authors: Baridwan Syamikar , Permatasari Henny , Setiawan Agus 
Published: July 2022

Background: Coronavirus disease 2019 (COVID-19) is a communicable disease that has infected millions of people in many countries, including Indonesia. Community health workers (CHWs) play a pivotal role in supporting primary health center programs, including in response to the COVID-19 pandemic.Methods: We conducted semi-structured in-depth interviews with thirteen CHWs in Makassar City, Indonesia. Data were analyzed using thematic analysis.Results: Six themes emerged from the interviews: (1) self-motivation; (2) valuable benefits; (3) noble duties; (4) perceived challenges; (5) meaningful support; and (6) way forward.Conclusions: Despite the challenges experienced by the participants, the involvement of CHWs is crucial to ensure that the community receives correct information and complies with health protocols to break the chain of COVID-19 transmission. The participants undertake the task with strong commitment and the feel of honor as they are trusted by the government and the community. The partnership between health service staffs and CHWs should be strengthened by providing sufficient support so COVID-19 cases in the community can be contained.
Introducción: La enfermedad por coronavirus 2019 (COVID-19) es una enfermedad transmisible que ha infectado a millones de personas en muchos países, incluida Indonesia. Los trabajadores comunitarios de la salud (CHW, por sus siglas en inglés) desempeñan un papel fundamental en el apoyo a los programas de los centros de salud primarios, incluso en respuesta a la pandemia de COVID-19.Método: Realizamos entrevistas en profundidad semiestructuradas con 13 CHW en la ciudad de Makassar, Indonesia. Los datos se analizaron mediante análisis temático.Resultados: De las entrevistas surgieron seis temas: (1) automotivación; (2) beneficios valiosos; (3) deberes nobles; (4) desafíos percibidos; (5) apoyo significativo; y (6) camino a seguir.Conclusión: A pesar de los desafíos experimentados por los participantes, la participación de los CHW es crucial para garantizar que la comunidad reciba información correcta y cumpla con los protocolos de salud para romper la cadena de transmisión de COVID-19. Los participantes emprenden la tarea con un fuerte compromiso y el sentimiento de honor ya que cuentan con la confianza del gobierno y la comunidad. La asociación entre el personal de los servicios de salud y los CHW debe fortalecerse brindando suficiente apoyo para que se puedan contener los casos de COVID-19 en la comunidad.
Treating urinary tract infections in public sector primary healthcare facilities in Cape Town, South Africa: A pharmaceutical perspective
Authors: Keuler N , Johnson Y , Coetzee R 
Published: July 2022

Background. Antibiotic resistance is a global healthcare burden complicating the management of infections. Urinary tract infections (UTIs) are commonly treated in primary care. Managing UTIs appropriately in primary care can combat antibiotic resistance. The treatment practices for UTIs in primary care in Western Cape Province, South Africa, are not well described.Objectives. To describe treatment of UTIs in adults in primary care in the Cape Town metropole public sector of the Western Cape. Method. A retrospective multicentre medical records review of patients diagnosed with UTIs was conducted during 1 October 2020 - 28 February 2021. Six public sector primary healthcare facilities were included in the study through random selection from three of the four substructures in the Cape Town metropole. Medical records of adult patients diagnosed with UTIs, through clinical diagnosis or microbiological testing, were identified via a selective sampling process. Data were collected from medical records using a standardised data collection tool.
Results. A total of 401 UTI episodes occurred in 383 patients during the study period. The majority of UTI episodes (84.3%) occurred in females, complicated UTIs (74.1%) were more common than uncomplicated UTIs, and nitrofurantoin (57.1%) was frequently prescribed, followed by ciprofloxacin (39.7%). Compliance with urine microscopy recommendations was low (6.7%), and antibiotics were appropriately selected in 75.0% of uncomplicated and 70.0% of complicated UTI episodes.
Conclusion. Interventions are required to improve compliance with treatment recommendations as per the standard treatment guidelines, especially when selecting the appropriate antibiotic, duration of therapy and urine microscopy.
Characterization of phenylalanine ammonia-lyase genes facilitating flavonoid biosynthesis from two species of medicinal plant Anoectochilus
Authors: Yang Lin , Li Wan-Chen , Fu Feng-ling , Qu Jingtao , Sun Fuai , Yu Haoqiang , Zhang Juncheng 
Published: July 2022

Background
Anoectochilus roxburghii and Anoectochilus formosanus, belong to the Anoectochilus genus, have been used for Chinese herbal drugs as well as health food. Phenylalanine ammonia-lyase (PAL), the key enzyme in primary metabolism and phenylpropanoid metabolism, produces secondary metabolites (flavonoids) in plants, which are beneficial for the biosynthesis of phenylpropanoid metabolites.

Methods
The PAL genes were cloned from A. formosanus and A. roxburghii according to our previous transcriptomic analysis. The PALs were introduced into pCAMBIA2300-35S-PAL-eGFP to generate 35S-PAL-eGFP. The constructs were further used for subcellular localization and transgenic Arabidopsis. The expression of AfPAL and ArPAL under precursor substance (L-Phe), NaCl, UV, and red-light were analyzed by real-time quantitative PCR (RT-qPCR).

Results
AfPAL and ArPAL , encoding 2,148 base pairs, were cloned from A. formosanus and A. roxburghii. The subcellular localization showed that the ArPAL and AfPAL were both localized in the nucleus with GPF. Quantitative RT-PCR analysis indicated that the ArPAL and AfPAL genes function in the phenylalanine pathway as well as response to induced conditions. Overexpression of the AfPAL and ArPAL could increase flavonoids and anthocyanin content in the transgenic Arabidopsis.

Discussion
The results suggest that AfPAL and ArPAL play a crucial role in the flavonoid biosynthesis in Anoectochilus. Also, our study provides new insights into the enrichment of secondary metabolites of traditional Chinese medicines A. formosanus and A. roxburghii, which can improve their medicinal active ingredients and be used for drug discovery in plants.
Evaluation of potential anti-metastatic and antioxidative abilities of natural peptides derived from Tecoma stans (L.) Juss. ex Kunth in A549 cells
Authors: Krobthong Sucheewin , Yingchutrakul Yodying , Sittisaree Wattanapong , Tulyananda Tatpong , Samutrtai Pawitrabhorn , Choowongkomon Kiattawee , Lao-On Udom 
Published: July 2022

Background
Tecoma stans (L.) Juss. ex Kunth is a well-known medicinal plant found in tropical and subtropical regions. It contains a broad range of bioactive compounds that exhibit many biological effects, including antidiabetic, antibacterial, and antioxidative activities. However, the effect of natural peptides from T. stans against cancer progression and free radical production is unknown. This study aims to evaluate the cytotoxic, anti-metastatic, and antioxidative activities of natural peptides from T. stans on A549 cells.

Methods
The natural peptides were extracted from the flower of T. stans using the pressurized hot water extraction (PHWE) method, followed by size exclusion chromatography and solid-phase extraction-C18. The cytotoxic and anti-metastatic effects of natural peptides were evaluated using MTT and transwell chamber assays, respectively. The free radical scavenging activity of natural peptides was determined using ABTS, DPPH, and FRAP assays. The cells were pretreated with the IC50 dosage of natural peptides and stimulated with LPS before analyzing intracellular reactive oxygen species (ROS) and proteomics.

Results
Natural peptides induced cell toxicity at a concentration of less than 1 ng/ml and markedly reduced cell motility of A549 cells. The cells had a migration rate of less than 10% and lost their invasion ability in the treatment condition. In addition, natural peptides showed free radical scavenging activity similar to standard antioxidants and significantly decreased intracellular ROS in the LPS-induced cells. Proteomic analysis revealed 1,604 differentially expressed proteins. The self-organizing tree algorithm (SOTA) clustered the protein abundances into eleven groups. The volcano plot revealed that the cancer-promoting proteins (NCBP2, AMD, MER34, ENC1, and COA4) were down-regulated, while the secretory glycoprotein (A1BG) and ROS-reducing protein (ASB6) were up-regulated in the treatment group.

Conclusion
The anti-proliferative and anti-metastatic activities of natural peptides may be attributed to the suppression of several cancer-promoting proteins. In contrast, their antioxidative activity may result from the up-regulation of ROS-reducing protein. This finding suggests that natural peptides from T. stans are viable for being the new potential anti-cancer and antioxidative agents.
Strategic Plans to Improve Production Processes in the Fishing Sector of Chimbote, Peru
Authors: Estrada Iván Saldaña 
Published: July 2022

The research aimed to determine if the strategic plans improve production processes in the fishing sector of Chimbote, 2020. The research focus is quantitative, applied type and non-experimental cross-sectional causal correlational design. The exhibition is composed of 165 people including businessmen and leaders of the fishing sector of Chimbote, 2020; two valid questionnaires with a reliability of 0.862 and 0.868 were used. Data analysis was performed using frequency tables and Spearman's Rho correlation coefficient. It was determined that the strategic plans significantly improve production processes in the fishing sector of Chimbote, 2020; being the Rho = 0.958 (high degree of correlation and positive) (p < 0.01). It was identified that the strategic plans have a regular level according to 63% of the entrepreneurs and leaders of the fishing sector of Chimbote, 2020. It was identified that the productive processes have a regularly efficient level according to 61.8% of the entrepreneurs and leaders of the fishing sector of Chimbote, 2020. The development of strategic plans could influence the development of fishing activities in an efficient manner, aiming to achieve the maximum use of raw materials, promoting high quality production processes.
An Assessment of Constraints Faced by Cabbage Growers in the East Khasi Hills District of Meghalaya: India
Authors: Sri Karuna , Choudhury Anju , Yumnam Anjoo , Singh Rishikantha , Dek Niveditha 
Published: July 2022

Aims: The study aimed to analyze the common, technical, economical, and marketing constraints faced by the cabbage farmers in East Khasi Hills district of Meghalaya (2019-2020).
Study Design: Purposive random sampling was employed in this study. One District and two blocks were selected purposively on the basis of their highest contribution to the area and production of cabbage further villages and respondents were selected randomly.
Place and Duration of Study: The study was conducted in the Mawrykneng and Mawkynrew blocks of East Khasi Hills District of Meghalaya. Five villages namely Umphyrnoi, Sohryngkhem, Rapleng, Tynroit and Tangsning were selected and 80 cabbage growers were selected for the study. The data was collected for the period of 2019-to 2020.
Methodology: The Garette ranking technique was worked out to analyze the constraints.
Results: The major economical constraints observed were high initial investment with the garette score of (77.95), followed by costly plant material (76.39). The major marketing constraints were high fluctuations in the market prices (63.22), and a lack of cooperative market (55.11). The top technical constraints were control of pests and diseases (53.35), water management (52.63), and the common constraints were lack of knowledge on the recommended package of practices (59.43) and labor problems (52.08).
Concluding remarks: Adequate need-based training programs may enhance the production of cabbage and thereby increases the farm income. Proper marketing channels and infrastructural development will help the growers fetch remunerative price for their produce.
Total Synthesis of Nitrogen‐Containing Natural Products Based on Palladium‐Catalyzed CH Functionalization
Authors: Tsukano Chihiro , Takemoto Yoshiji 
Published: July 2022

AbstractCH functionalization has witnessed remarkable recent advances and has been widely employed in key reactions in the total synthesis of natural products. In this article, we present the palladium‐catalyzed total synthesis of nitrogen‐containing natural products using CH functionalization as the key reaction.