bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate social responsibility and innovative work behavior: Is it a matter of perceptions?
Authors: Alhmoudi Ranya Saeed , Singh Sanjay Kumar , Caputo Francesco , Riso Teresa , Iandolo Francesca 
Published: June 2022

AbstractThe paper investigates the influence of corporate social responsibility (CSR) on Innovative Work Behavior (IWB). The mediating role of passion and organizational commitment is investigated for understanding the effect of CSR on companies' performances by adopting a behavioral perspective. Based on the exploratory literature review conducted during the period from 1990 to 2020 and the content analysis method, we explore possible relationships among CSR, human capital, relational capital, and innovative work behaviors. Building upon the evidence from the literature review, a set of propositions have been defined for supporting both researchers and practitioners in enhancing the potential contribution of perceived CSR to improve companies' performance by adopting IWBs. The paper enriches ongoing debate about CSR's influence on companies' performances investigating the pivotal role of perceptions about CSR practices in influencing IWBs within the business field.
Caregiver appraisals of lucid episodes in people with late‐stage Alzheimer's disease or related dementias
Authors: Griffin Joan M. , Kim Kyungmin , Gaugler Joseph E. , Biggar Virginia S. , Frangiosa Theresa , Bangerter Lauren R. , Batthyany Alexander , Finnie Dawn M. , Lapid Maria I. 
Published: June 2022

AbstractIntroductionLittle is known about how family caregivers who witness unexpected and spontaneous communication among people in late stages of Alzheimer's disease and related dementias (ADRD) appraise these episodes of lucidity (EL).MethodsIn an electronic, cross‐sectional survey for former and current caregivers who participate in UsAgainstAlzheimer's A‐LIST®, participants who reported witnessing an EL were asked how positive and stressful ELs were, if they made or changed decisions based on an EL, and what resources they sought out to explain ELs.ResultsCaregivers reported 72% of ELs to be quite a bit or very positive, 17% to be stressful, and 10% to be both stressful and positive. Twelve percent of caregivers changed care plans because of ELs and 13% sought out information about ELs.DiscussionThese exploratory data suggest caregiver reactions to EL vary. Caregivers may change or postpone care decisions due to EL, and few resources exist to address caregiver queries about EL.
Distribution models calibrated with independent field data predict two million ancient and veteran trees in England
Authors: Nolan Victoria , Gilbert Francis , Reed Tom , Reader Tom 
Published: June 2022

AbstractLarge, citizen‐science species databases are powerful resources for predictive species distribution modeling (SDM), yet they are often subject to sampling bias. Many methods have been proposed to correct for this, but there exists little consensus as to which is most effective, not least because the true value of model predictions is hard to evaluate without extensive independent field sampling. We present here a nationwide, independent field validation of distribution models of ancient and veteran trees, a group of organisms of high conservation importance, built using a large and internationally unique citizen‐science database: the Ancient Tree Inventory (ATI). This validation exercise presents an opportunity to test the performance of different methods of correcting for sampling bias, in the search for the best possible prediction of ancient and veteran tree distributions in England. We fitted a variety of distribution models of ancient and veteran tree records in England in relation to environmental predictors and applied different bias correction methods, including spatial filtering, background manipulation, the use of bias files, and, finally, zero‐inflated (ZI) regression models, a new method with great potential to investigate and remove sampling bias in species data. We then collected new independent field data through systematic surveys of 52 randomly selected 1‐km2 grid squares across England to obtain abundance estimates of ancient and veteran trees. Calibration of the distribution models against the field data suggests that there are around eight to 10 times as many ancient and veteran trees present in England than the records currently suggest, with estimates ranging from 1.7 to 2.1 million trees compared to the 200,000 currently recorded in the ATI. The most successful bias correction method was systematic sampling of occurrence records, although the ZI models also performed well, significantly predicting field observations and highlighting both likely causes of undersampling and areas of the country in which many unrecorded trees are likely to be found. Our findings provide the first robust nationwide estimate of ancient and veteran tree abundance and demonstrate the enormous potential for distribution modeling based on citizen‐science data combined with independent field validation to inform conservation planning.
Archetype models upscale understanding of natural pest control response to land‐use change
Authors: Alexandridis Nikolaos , Marion Glenn , Chaplin‐Kramer Rebecca , Dainese Matteo , Ekroos Johan , Grab Heather , Jonsson Mattias , Karp Daniel S. , Meyer Carsten , O'Rourke Megan E. , Pontarp Mikael , Poveda Katja , Seppelt Ralf , Smith Henrik G. , Walters Richard J. , Clough Yann , Martin Emily A. 
Published: June 2022

AbstractControl of crop pests by shifting host plant availability and natural enemy activity at landscape scales has great potential to enhance the sustainability of agriculture. However, mainstreaming natural pest control requires improved understanding of how its benefits can be realized across a variety of agroecological contexts. Empirical studies suggest significant but highly variable responses of natural pest control to land‐use change. Current ecological models are either too specific to provide insight across agroecosystems or too generic to guide management with actionable predictions. We suggest obtaining the full benefit of available empirical, theoretical, and methodological knowledge by combining trait‐mediated understanding from correlative studies with the explicit representation of causal relationships achieved by mechanistic modeling. To link these frameworks, we adapt the concept of archetypes, or context‐specific generalizations, from sustainability science. Similar responses of natural pest control to land‐use gradients across cases that share key attributes, such as functional traits of focal organisms, indicate general processes that drive system behavior in a context‐sensitive manner. Based on such observations of natural pest control, a systematic definition of archetypes can provide the basis for mechanistic models of intermediate generality that cover all major agroecosystems worldwide. Example applications demonstrate the potential for upscaling understanding and improving predictions of natural pest control, based on knowledge transfer and scientific synthesis. A broader application of this mechanistic archetype approach promises to enhance ecology's contribution to natural resource management across diverse regions and social‐ecological contexts.
Synthesis of Thioalkynes by Desilylative Sonogashira Cross‐Coupling of Aryl Iodides and 1‐Methylthio‐2‐(trimethylsilyl)ethyne
Authors: Cao Yang , Huang Yang , Blakemore Paul R. 
Published: June 2022

Abstract1‐Methylthio‐2‐arylethynes were prepared in typically good to excellent yields from aryl iodides and 1‐methylthio‐2‐(trimethylsilyl)ethyne by a desilylative Sonogashira process employing Pd(PPh3)2Cl2 (1 mol %), CuI (10 mol %), and K2CO3 (6 eq) in MeOH‐Et3N‐THF (1 : 2 : 2) at rt for 16 h (16 examples, 31–96 % yield). Thienyl and pyridyl iodides (all regioisomers) were similarly converted to 1‐methylthio‐2‐heteroarylethynes (5 examples, 54–82 % yield). The process was extended with similar results to comparable thioalkynes substituted on sulfur by n‐alkyl, s‐alkyl, and aryl groups.
H‐Bonded Counterion‐Directed Catalysis: Enantioselective Gold(I)‐Catalyzed Addition to 2‐Alkynyl Enones as a Case Study
Authors: Martí Àlex , Montesinos‐Magraner Marc , Echavarren Antonio M. , Franchino Allegra 
Published: June 2022

AbstractH‐bonded counterion‐directed catalysis (HCDC) is a strategy wherein a chiral anion that is hydrogen‐bonded to the achiral ligand of a metal complex is responsible for enantioinduction. In this article we present the application of H‐bonded counterion‐directed catalysis to the Au(I)‐catalyzed enantioselective tandem cycloisomerization‐addition reaction of 2‐alkynyl enones. Following the addition of C‐, N‐ or O‐centered nucleophiles, bicyclic furans were obtained in moderate to excellent yield and enantioselectivity (28 examples, 59–96 % yield, 62 : 38 to 95 : 5 er). The optimal catalytic system, comprising a phosphinosquaramide Au(I) chloride complex and a BINOL‐derived phosphoramidate Ag(I) salt, was selected in a combinatorial fashion from a larger library with the help of high‐throughput screening. An enantioselectivity switch of ca. 120 Δee% was observed upon addition of the achiral Au(I) component to the Ag(I) salt.
Visible‐Light‐Driven Photocatalyst‐Free Preparation of (Z)β‐Nitroacrylate Isomers
Authors: Khan Muhammad Ehtisham Ibraheem , Di Terlizzi Lorenzo , Protti Stefano , Palmieri Alessandro 
Published: June 2022

AbstractWe herein report the visible light driven isomerization (E)‐β‐nitroacrylates into the corresponding (Z) stereoisomers. The reaction occurs under both batch and continuous flow conditions and afford the desired isomer in quantitative yields.
Sensory processing and eating behaviours in autism: A systematic review
Authors: Nimbley Emy , Golds Lisa , Sharpe Helen , Gillespie‐Smith Karri , Duffy Fiona 
Published: June 2022

AbstractObjectivesThe aim of this study was to assess the relationship between sensory processing and a broad range of eating behaviours across the lifespan.MethodsFive electronic databases of published and unpublished quantitative studies were systematically searched, evaluated for risk of bias and synthesised according to identified eating outcomes.ResultsAcross 25 studies, there was consistent evidence of a relationship between sensory processing and a range of eating behaviours. There was early evidence for the particular role of taste/smell sensitivities, as well as hypersensitivities, although future research is needed looking at different sensory patterns and modalities. There was also tentative evidence to suggest this relationship extends across development.DiscussionStudy findings are discussed in relation to implications for sensory‐based eating and feeding interventions and the development of eating disorders. Methodological and conceptual limitations are discussed and suggestions for future research are made to address these limitations. A broader investigation of multi‐sensory issues and clearly defined eating behaviours, including disordered eating in clinically diagnosed samples, will allow for a more comprehensive and robust understanding of the relationship between sensory processing and eating behaviours in autism.
Factors associated with potentially inappropriate opioid use in community‐living older adults consulting in primary care
Authors: D’Aiuto Carina , Lunghi Carlotta , Guénette Line , Berbiche Djamal , Pitrou Isabelle , Bertrand Karine , Vasiliadis Helen‐Maria 
Published: June 2022

AbstractObjectiveTo study the factors associated with opioid use and potentially inappropriate opioid use (PIOU) in primary care older adults with non‐cancer pain referring to the conceptual framework developed by the American Agency for Healthcare Research and Quality.MethodsThis is a secondary analysis of health survey and medico‐administrative data from Québec, Canada. Individuals aged ≥65 were recruited between 2011 and 2013 in primary care clinics to participate in face‐to‐face interviews. The sample included 945 older adults without a malignant tumor over the study period or any tumor in the 2 years surrounding opioid use. Opioid use within a 3 year follow‐up period was identified from the public drug plan database. Potentially inappropriate opioid use (PIOU) was defined using the American Geriatrics Society Beers 2019 list. Multinomial regression analyses were performed to study the factors (patient, pain, substance use, provider, healthcare system) associated with opioid use and PIOU.ResultsIn this sample of older adults, 26.2% used an opioid and 18.4% were categorized as PIOU. Factors associated with PIOU compared to opioid use included female sex, higher psychological distress, number of emergency department visits, and recruitment type of healthcare practice. Factors associated with PIOU compared to no use included female sex, country of origin, presence of a trauma, physical/psychiatric multimorbidity, number of outpatient consultations, pain severity/type, and number of prescribers.ConclusionsMental health and health system factors were associated with PIOU. Results highlights the importance of a multidisciplinary approach for pain management, and the urgent need for implementing organizational efforts to optimize opioid use in primary care.
Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors
Authors: Zaremba Anne , Jansen Philipp , Murali Rajmohan , Mayakonda Anand , Riedel Anna , Philip Manuel , Rose Christian , Schaller Jörg , Müller Hansgeorg , Kutzner Heinz , Möller Inga , Stadtler Nadine , Kretz Julia , Sucker Antje , Bankfalvi Agnes , Livingstone Elisabeth , Zimmer Lisa , Horn Susanne , Paschen Annette , Plass Christoph , Schadendorf Dirk , Hadaschik Eva , Lutsik Pavlo , Griewank Klaus 
Published: June 2022

AbstractAccurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow‐up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases a definitive diagnostic assessment remains challenging and additional diagnostic biomarkers would be advantageous. We analyzed melanomas, nevi, Spitz nevi and atypical spitzoid tumors using parallel sequencing (exons of 611 genes and 507 gene translocation analysis) and methylation arrays (850k Illumina EPIC). By combining detailed genetic and epigenetic analysis with reference‐based and reference‐free DNA methylome deconvolution we compared Spitz nevi to nevi and melanoma and assessed the potential for these methods in classifying challenging spitzoid tumors. Results were correlated with clinical and histologic features. Spitz nevi were found to cluster independently of nevi and melanoma and demonstrated a different mutation profile. Multiple copy number alterations and TERT promoter mutations were identified only in melanomas. Genome‐wide methylation in Spitz nevi was comparable to benign nevi while the Leukocytes UnMethylation for Purity (LUMP) algorithm in Spitz nevi was comparable to melanoma. Histologically difficult to classify Spitz tumor cases were assessed which, based on methylation arrays, clustered between Spitz nevi and melanoma and in terms of genetic profile or copy number variations demonstrated worrisome features suggesting a malignant neoplasm. Comprehensive sequencing and methylation analysis verify Spitz nevi as an independent melanocytic entity distinct from both nevi and melanoma. Combined genetic and methylation assays can offer additional insights in diagnosing difficult to classify Spitzoid tumors.
Polyethylenimine‐grafted mesoporous silica nanocarriers markedly enhance the bactericidal effect of curcumin against Staphylococcus aureus biofilm
Authors: Pamukçu Ayşenur , Erdoğan Nursu , Şen Karaman Didem 
Published: June 2022

AbstractThe recalcitrant nature of biofilms makes biofilm‐associated infections difficult to treat in modern medicine. Biofilms have a high vulnerability to antibiotics and a limited repertoire of antibiotics could act on matured biofilms. This issue has resulted in a gradual paradigm shift in drug discovery and therapy, with anti‐biofilm compounds being sought alongside new drug carriers. A potential solution to biofilm‐associated infections is to employ antibiofilm treatments, which can attack biofilms from many fronts. Nanocarriers are promising in this regard because they can be entrapped within biofilm matrix, target biofilm matrix, and provide local drug delivery to inhibit biofilm formation. In this study, curcumin as an herbal extract was loaded onto hyperbranched polyethylenimine‐grafted mesoporous silica nanoparticles (F‐MSN‐PEI/Cur) and antibiofilm investigations were performed. The F‐MSN‐PEI/Cur design has the potential to repurpose curcumin as an antibiofilm agent by increasing its solubility and lowering the required doses for the destruction of matured biofilms as well as suppressing biofilm development. Using imaging and spectroscopic techniques, we assessed the interaction of F‐MSN‐PEI/Cur with Staphylococcus aureus bacterial cells and determined the impact of F‐MSN‐PEI/Cur on eradicating matured biofilms and suppressing biofilm development. The F‐MSN‐PEI/Cur design is highly cytocompatible, as observed by the cytotoxicity screening investigations on L929 mouse fibroblast cell line. Our findings show that F‐MSN‐PEI/Cur design reduces the bacterial cell viability, inhibits biofilm formation, and induces biofilm eradication, which is attributed to F‐MSN‐PEI/Cur design having the potential to repurpose the antibiofilm activity of curcumin‐herbal extract.
Modulatory action of withaferin‐A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol‐induced atherosclerosis in experimental rats
Authors: Zhang Liwei , Shi Yan , Yan Mingzhu , Zhang Guangping 
Published: June 2022

AbstractStatins are widely used lipid‐lowering drugs that cause many side effects. Withaferin‐A (WA), popularly known as Ashwagandha, an ancient Indian medicinal herb, is extracted from Withania somnifera. Anti‐atherosclerotic effect of WA has been reported. However, the mechanism remains unknown. Hence, we planned this study to investigate the WA mechanism in anti‐atherosclerosis in a rat model. High cholesterol diet (HCD) was fed to induce atherosclerosis in Sprague–Dawley male rats. Five groups (N = 6 rats/group) were fed with normal diet, HCD, WA (10 mg/kg bw)+HCD, lovastatin (LS: 10 mg/kg bw)+HCD, WA (10 mg/kg bw) respectively for 90 days. Statistical analysis was done by GraphPad Prism (version 8.0.1) using one‐way analysis of variance (ANOVA) followed by post hoc Duncan's test with a significance level (p < 0.05). The groups were compared for lipid profiles, oxidative stress, lipid peroxidation, inflammatory mediators, apoptotic markers, and histopathological changes in the liver and aorta. Treatment with HCD increased lipid profiles, inflammatory mediators, cytokines, and lipid peroxidation. WA as well as LS treatments significantly decreased these parameters restored the antioxidant status, and reduced lipid peroxidation (p < 0.05). Histopathological studies revealed that WA and LS reduced the hepatic fat and aortic plaque. WA reduced apoptosis via augmentation of phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) pathway; increased B‐cell lymphoma 2 and inhibited Bcl‐2 associated X‐protein proapoptotic proteins; TNF receptor superfamily member 6, Bim, caspase‐3, and ‐9; demonstrated significant hypolipidemic and anti‐inflammatory properties against HCD induced atherosclerosis in rats through regulation of inflammatory mediators and apoptosis via the PI3K/AKT signaling pathway.
Induction of endoplasmic reticulum stress markers in an acromegaly model
Authors: Elbialy Abdalla , Sulidan Kaidiliayi , Bhuiyan Afsana , Igarashi Yoji , Yoshitake Kazutoshi , Yamanouchi Dai , Kang Junsu , Asakawa Shuichi , Watabe Shugo , Kinoshita Shigeharu 
Published: June 2022

AbstractAcromegaly is a growth hormone (GH) excess pathological condition in humans. Acromegaly is associated with somatic disfigurement and a wide range of systemic manifestations such as arthritis, neuropathy, carpal tunnel syndrome, reproductive disorders, metabolic disorders, and gastrointestinal complications. The influence of excess GH on the cellular level could aid in understanding the root causes of acromegaly‐related health complications. Previously, we found that GH excess induces DNA damage to somatic cells and reduces the stem cells number and causes premature aging. In this study, an in‐depth analysis of the acromegaly RNAseq data revealed the disruption of important biological cellular processes. Gene set enrichment analysis, heatmap, and enrichment analysis of acromegaly RNAseq data revealed induction of endoplasmic reticulum (ER) stress markers in various organs. Interestingly, the induction of ER stress was even more apparent than in aged zebrafish. Splicing of box‐binding protein‐1 (XBP1) mRNA is a hallmark of ER stress. Therefore, we quantified spliced XBP1 mRNA in different organs of our acromegaly model. Thus, our study emphasizes the importance of ER stress in GH oversecretion, which is important for understanding the health complications of acromegaly.
Engineering the simply asymmetric Morita–Baylis–Hillman reactions in a sodium phosphate buffer system: from enzyme‐ to proline‐catalyzed transformation
Authors: Du Xiaotong , Cui Xiumei , Gao Xiaojun , Zheng Liangyu 
Published: June 2022

AbstractBACKGROUNDThe Morita–Baylis–Hillman (MBH) reaction is an important carbon–carbon bond‐forming reaction. However, most MBH reactions suffer disadvantages such as high amounts of catalyst and hazardous solvents, long reaction time, low reactivity and selectivity. In this study, simple, cost‐effective and eco‐friendly asymmetric MBH reactions are developed.RESULTSFollowing our previous study that the commercial Candida antarctica lipase B (lipase CalB)‐catalyzed MBH reaction can be activated by introducing an amide compound as a co‐catalyst, the recombinant lipase CalBs (rCalBs) with polyamino acid tails are first attempted to be used in the same MBH reaction, but unfortunately chiral MBH products are not obtained. Enoate reductase (ER) is found to give asymmetric transformation of the MBH reaction with a conversion of 36.9% and enantiomeric excess (e.e.p) of 6.8% when other enzyme resources are expanded. According to the observation that the surface amino acids of ER may be key factors in achieving the MBH reaction, single amino acids are subsequently selected to catalyze the MBH reactions, and the reverse configuration of (R)‐ and (S)‐MBH products with e.e.p of 63.9% and 62.1% for single l‐proline‐ and d‐proline‐catalyzed MBH reactions are reached only in 4 h, respectively.CONCLUSIONProline can afford the asymmetric MBH reaction in a sodium phosphate buffer only in 4 h without the help of the other co‐catalyst in our study, which is superior to those reported. The study aims to introduce a novel phenomenon observed from enzyme‐catalyzed to proline‐catalyzed MBH reactions. © 2022 Society of Chemical Industry (SCI).