bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consequences of gestational diabetes mellitus on neonatal cardiovascular health: MySweetHeart Cohort study
Authors: Di Bernardo Stefano C. , Lava Sebastiano A. G. , Epure Adina Mihaela , Younes Sandrine Estoppey , Chiolero Arnaud , Sekarski Nicole ,   on behalf of MySweetHeart Research Group, Arhab Amar , Bovet Pascal , Chiolero Arnaud , Di Bernardo Stefano , Epure Adina Mihaela , Gilbert Leah , Gross Justine , Horsch Antje , Lanzi Stefano , Mayerat Seyda , Mivelaz Yvan , Puder Jardena J. , Quansah Dan , Rossel Jean‐Benoit , Simeoni Umberto , Stuijfzand Bobby , Vial Yvan 
Published: November 2022

AbstractBackgroundHyperglycaemic disorders of pregnancy are associated with offspring cardiovascular alterations.MethodsMySweetHeart cohort study aimed to assess the effect of maternal gestational diabetes (GDM) on offsprings’ cardiovascular health. Newborns underwent clinical and echocardiographic examinations between 2016 and 2020.ResultsCompared to mothers without GDM (n = 141), mothers with GDM (n = 123) were more likely to have had GDM in previous pregnancies and had higher weight, BMI, blood glucose, and HbA1c. Newborns of both groups showed similar clinical characteristics. Echocardiography was performed on the 3rd (interquartile range, IQR, 2nd–4th) day of life in 101 offsprings of mothers without and 116 offsprings of mothers with GDM. Left ventricular (LV) mass was similar. Children born to mothers with GDM had a thicker posterior LV wall (z-score +0.15, IQR –0.38/0.62, versus +0.47, IQR –0.11/+1.1,p = 0.004), a smaller end-systolic (1.3 mL, IQR 1.0–1.5 mL, versus 1.4 mL, IQR 1.2–1.8 mL,p = 0.044) but a similar end-diastolic LV volume. They also had shorter tricuspid valve flow duration and aortic valve ejection time, lower tricuspid E-wave and pulmonary valve velocities.ConclusionsNewborns of mothers with or without GDM had similar clinical characteristics and LV mass. However, some echocardiographic differences were detected, suggesting an altered myocardial physiology among infants of mothers with GDM.RegistrationClinicalTrials.gov (NCT02872974).ImpactHyperglycaemic disorders of pregnancy are known to be associated with offspring cardiovascular alterations.Clinical characteristics and estimated left ventricular (LV) mass were similar in children issued from mothers with and without gestational diabetes (GDM).Children born to mothers with GDM had a thicker posterior LV wall and a smaller end-systolic LV volume.Although LV mass is not different, myocardial physiology may be altered in these infants. Further studies should investigate the endothelial function of this population and the cardiovascular evolution of these children over time.
Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases
Authors: Duchnowska Renata , Supernat Anna Maria , Pęksa Rafał , Łukasiewicz Marta , Stokowy Tomasz , Ronen Roy , Dutkowski Janusz , Umińska Monika , Iżycka-Świeszewska Ewa , Kowalczyk Anna , Och Waldemar , Rucińska Monika , Olszewski Wojciech P. , Mandat Tomasz , Jarosz Bożena , Bieńkowski Michał , Biernat Wojciech , Jassem Jacek 
Published: November 2022

AbstractBrain metastases (BMs) in ovarian cancer (OC) are a rare event. BMs occur most frequently in high-grade serous (HGS) OC. The molecular features of BMs in HGSOC are poorly understood. We performed a whole-exome sequencing analysis of ten matched pairs of formalin-fixed paraffin-embedded samples from primary HGSOC and corresponding BMs. Enrichment significance (pvalue; false discovery rate) was computed using the Reactome, the Kyoto Encyclopedia of Genes and Genomes pathway collections, and the Gene Ontology Biological Processes. Germline DNA damage repair variants were found in seven cases (70%) and involved theBRCA1,BRCA2,ATM,RAD50,ERCC4,RPA1,MLHI, andATRgenes. Somatic mutations ofTP53were found in nine cases (90%) and were the only stable mutations between the primary tumor and BMs. Disturbed pathways in BMs versus primary HGSOC constituted a complex network and included the cell cycle, the degradation of the extracellular matrix, cell junction organization, nucleotide metabolism, lipid metabolism, the immune system, G-protein-coupled receptors, intracellular vesicular transport, and reaction to chemical stimuli (Golgi vesicle transport and olfactory signaling). Pathway analysis approaches allow for a more intuitive interpretation of the data as compared to considering single-gene aberrations and provide an opportunity to identify clinically informative alterations in HGSOC BM.
Numerical optimization of pacing strategy in cross-country skiing based on Gauss pseudo-spectral method
Authors: Ni Xu , Liu Jiawei , Zhang Shuguang , Ke Peng 
Published: November 2022

AbstractIn cross-country skiing competitions, the choice of pacing strategy is of decisive significance to athletes' performance. A reasonable pacing strategy is essential for athletes to improve their performance. In this paper, the mathematical models of cross-country skiing simulation and pacing optimization are established, including motion model, athlete power output model, and optimization model. The actual competition data of a Chinese athlete in Guyangshu 1.5 km track was compared with the model simulation results. The whole process time error is less than 3%, which verifies the accuracy of the motion and power output model. Gauss pseudo-spectral method is applied to the optimization model. By changing the distribution of athletes' power output, the racing time is minimized under the condition that the total energy output remains unchanged. Compared with the pacing strategy before optimization, the optimized racing time was shortened by 12.6 s, which verifies the effectiveness of the optimization model. Optimized results show that in the first significant uphill section, a recommendation is to use a more conservative strategy, while in the latter half of uphill sections the power output should be increased.
Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma
Authors: Liu Chao-Yu , Liu Chen-Chi , Li Anna Fen-Yau , Hsu Tien-Wei , Lin Jiun-Han , Hung Shih-Chieh , Hsu Han-Shui 
Published: November 2022

AbstractThis study aimed to evaluate the protein expression of glutathione peroxidase 4 (GPX4) in resected non-small cell lung cancer (NSCLC). The clinical relevance and prognostic significance of GPX4 expression were analyzed. We reviewed patients with resected NSCLCs at Taipei Veterans General Hospital between September 2002 and January 2018. Available paraffin-embedded specimens were retrieved for immunohistochemistry (IHC) staining to detect GPX4 expression. The cutoff value for defining GPX4 positivity was determined according to the percentage of tumor stained in the microscopic field. The correlation between immune expression, clinicopathologic data, overall survival (OS), and disease-free survival (DFS) were analyzed. A total of 265 NSCLC specimens were retrieved for IHC staining. GPX4 expression positive was in 192 (72.5%) according to a cutoff value of 5%. GPX4 was a significant prognostic factor for OS and DFS on multivariate analysis at both 5% and 25% cutoff values. GPX4 expression was associated with poor OS and DFS, especially in lung adenocarcinoma (p = 0.008, and 0.027, respectively). In conclusions, IHC analysis revealed that GPX4 expression was associated with poor survival outcomes in patients with resected lung adenocarcinoma. Further research is needed to understand the role of GPX4 in tumorigenesis and the underlying mechanism responsible for survival outcomes in patients with resected lung adenocarcinoma.
Inverse forgetting in unconscious episodic memory
Authors: Pacozzi Luca , Knüsel Leona , Ruch Simon , Henke Katharina 
Published: November 2022

AbstractForming memories of experienced episodes calls upon the episodic memory system. Episodic encoding may proceed with and without awareness of episodes. While up to 60% of consciously encoded episodes are forgotten after 10 h, the fate of unconsciously encoded episodes is unknown. Here we track over 10 h, which are filled with sleep or daytime activities, the retention of unconsciously and consciously experienced episodes. The episodes were displayed in cartoon clips that were presented weakly and strongly masked for conscious and unconscious encoding, respectively. Clip retention was tested for distinct clips directly after encoding, 3 min and 10 h after encoding using a forced-choice test that demands deliberate responses in both consciousness conditions. When encoding was conscious, retrieval accuracy decreased by 25% from 3 min to 10 h, irrespective of sleep or wakefulness. When encoding was unconscious, retrieval accuracy increased from 3 min to 10 h and depended on sleep. Hence, opposite to the classic forgetting curve, unconsciously acquired episodic memories strengthen over time and hinge on sleep on the day of learning to gain influence over human behavior.
Towards a robust criterion of anomalous diffusion
Authors: Sposini Vittoria , Krapf Diego , Marinari Enzo , Sunyer Raimon , Ritort Felix , Taheri Fereydoon , Selhuber-Unkel Christine , Benelli Rebecca , Weiss Matthias , Metzler Ralf , Oshanin Gleb 
Published: November 2022

AbstractAnomalous-diffusion, the departure of the spreading dynamics of diffusing particles from the traditional law of Brownian-motion, is a signature feature of a large number of complex soft-matter and biological systems. Anomalous-diffusion emerges due to a variety of physical mechanisms, e.g., trapping interactions or the viscoelasticity of the environment. However, sometimes systems dynamics are erroneously claimed to be anomalous, despite the fact that the true motion is Brownian—or vice versa. This ambiguity in establishing whether the dynamics as normal or anomalous can have far-reaching consequences, e.g., in predictions for reaction- or relaxation-laws. Demonstrating that a system exhibits normal- or anomalous-diffusion is highly desirable for a vast host of applications. Here, we present a criterion for anomalous-diffusion based on the method of power-spectral analysis of single trajectories. The robustness of this criterion is studied for trajectories of fractional-Brownian-motion, a ubiquitous stochastic process for the description of anomalous-diffusion, in the presence of two types of measurement errors. In particular, we find that our criterion is very robust for subdiffusion. Various tests on surrogate data in absence or presence of additional positional noise demonstrate the efficacy of this method in practical contexts. Finally, we provide a proof-of-concept based on diverse experiments exhibiting both normal and anomalous-diffusion.
Mitochondrial RNA stimulates beige adipocyte development in young mice
Authors: Hoang Anh Cuong , Sasi-Szabó László , Pál Tibor , Szabó Tamás , Diedrich Victoria , Herwig Annika , Landgraf Kathrin , Körner Antje , Röszer Tamás 
Published: November 2022

AbstractChildhood obesity is a serious public health crisis and a critical factor that determines future obesity prevalence. Signals affecting adipocyte development in early postnatal life have a strong potential to trigger childhood obesity; however, these signals are still poorly understood. We show here that mitochondrial (mt)RNA efflux stimulates transcription of nuclear-encoded genes for mitobiogenesis and thermogenesis in adipocytes of young mice and human infants. While cytosolic mtRNA is a potential trigger of the interferon (IFN) response, young adipocytes lack such a response to cytosolic mtRNA due to the suppression of IFN regulatory factor (IRF)7 expression by vitamin D receptor signalling. Adult and obese adipocytes, however, strongly express IRF7 and mount an IFN response to cytosolic mtRNA. In turn, suppressing IRF7 expression in adult adipocytes restores mtRNA-induced mitobiogenesis and thermogenesis and eventually mitigates obesity. Retrograde mitochondrion-to-nucleus signalling by mtRNA is thus a mechanism to evoke thermogenic potential during early adipocyte development and to protect against obesity.
Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology
Authors: Pereira Joana B. , Janelidze Shorena , Strandberg Olof , Whelan Christopher D. , Zetterberg Henrik , Blennow Kaj , Palmqvist Sebastian , Stomrud Erik , Mattsson-Carlgren Niklas , Hansson Oskar 
Published: November 2022

AbstractThe role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying Alzheimer’s disease (AD)1. Here, we measured the microglial marker soluble TREM2 and the disease-associated microglial activation stage 2 markers AXL, MERTK, GAS6, LPL, CST7, SPP1 and CSF1 in nondemented individuals from the Swedish BioFINDER-2 cohort who underwent longitudinal tau-positron emission tomography (PET), amyloid-PET and global cognitive assessment. To assess whether baseline microglial markers had an effect on AD-related changes, we studied three sub-groups of individuals: 121 with evidence of amyloid-PET pathology (A+), 64 with additional evidence of tau-PET pathology (A+T+) and 159 without amyloid- or tau-PET pathology (A−T−). Our results showed that increased levels of TREM2 were associated with slower amyloid accumulation in A+ individuals in addition to slower tau deposition and cognitive decline in A+T+ subjects. Similarly, higher levels of AXL, MERTK, GAS6, LPL, CST7 and CSF1 predicted slower tau accumulation and/or cognitive decline in the A+T+ group. These findings have important implications for future therapeutic strategies aiming to boost microglial protective functions in AD.
Defining shapes of two-dimensional crystals with undefinable edge energies
Authors: Wang Luqing , Shirodkar Sharmila N. , Zhang Zhuhua , Yakobson Boris I. 
Published: November 2022

AbstractThe equilibrium shape of crystals is a fundamental property of both aesthetic appeal and practical importance: the shape and its facets control the catalytic, light-emitting, sensing, magnetic and plasmonic behaviors. It is also a visible macro-manifestation of the underlying atomic-scale forces and chemical makeup, most conspicuous in two-dimensional (2D) materials of keen current interest. If the crystal surface/edge energy is known for different directions, its shape can be obtained by the geometric Wulff construction, a tenet of crystal physics; however, if symmetry is lacking, the crystal edge energy cannot be defined or calculated and thus its shape becomes elusive, presenting an insurmountable problem for theory. Here we show how one can proceed with auxiliary edge energies towards a constructive prediction, through well-planned computations, of a unique crystal shape. We demonstrate it for challenging materials such as SnSe, which is of C2v symmetry, and even AgNO2 of C1, which has no symmetry at all.
Do Miras show long secondary periods?
Authors: Pawlak Michał 
Published: November 2022

Aims. The long secondary period (LSP) phenomenon, which is commonly observed in pulsating red giants, has not been detected in any Mira yet. The goal of this work is to verify, if there is a physical reason for this or if it is simply an observational bias.
Methods. The OGLE-III Sample of Long Period Variables in the Large Magellanic Cloud, containing 1663 Miras, is used to perform a search for secondary periodicity in these objects and identify candidates for the long secondary period stars based on the location on the period-luminosity diagram.
Results. Out of 1663 Miras, 108 were identified as potential candidates, with variability broadly consistent with LSP. This makes 7% of the whole Mira sample in the Large Magellanic Cloud. Most, if not all, of the Mira LSP candidates are C-rich stars.
Conclusions. The results of this analysis suggest that Miras may exhibit long secondary periods. However, the long-term variability can also be related to the period and amplitude irregularities that Miras are known to exhibit. Further study will be necessary to draw a definitive conclusion.
Gas kinematics around filamentary structures in the Orion B cloud
Authors: Gaudel Mathilde , Orkisz Jan H. , Gerin Maryvonne , Pety Jérôme , Roueff Antoine , Marchal Antoine , Levrier François , Miville-Deschênes Marc-Antoine , Goicoechea Javier R. , Roueff Evelyne , Le Petit Franck , de Souza Magalhaes Victor , Palud Pierre , Santa-Maria Miriam G. , Vono Maxime , Bardeau Sébastien , Bron Emeric , Chainais Pierre , Chanussot Jocelyn , Gratier Pierre , Guzman Viviana , Hughes Annie , Kainulainen Jouni , Languignon David , Le Bourlot Jacques , Liszt Harvey , Öberg Karin , Peretto Nicolas , Sievers Albrecht , Tremblin Pascal 
Published: November 2022

Context. Understanding the initial properties of star-forming material and how they affect the star formation process is key. From an observational point of view, the feedback from young high-mass stars on future star formation properties is still poorly constrained.
Aims. In the framework of the IRAM 30m ORION-B large program, we obtained observations of the translucent (2 ≤ AV < 6 mag) and moderately dense gas (6 ≤ AV < 15 mag), which we used to analyze the kinematics over a field of 5 deg2 around the filamentary structures.
Methods. We used the Regularized Optimization for Hyper-Spectral Analysis (ROHSA) algorithm to decompose and de-noise the C18O(1–0) and 13CO(1–0) signals by taking the spatial coherence of the emission into account. We produced gas column density and mean velocity maps to estimate the relative orientation of their spatial gradients.
Results. We identified three cloud velocity layers at different systemic velocities and extracted the filaments in each velocity layer. The filaments are preferentially located in regions of low centroid velocity gradients. By comparing the relative orientation between the column density and velocity gradients of each layer from the ORION-B observations and synthetic observations from 3D kinematic toy models, we distinguish two types of behavior in the dynamics around filaments: (i) radial flows perpendicular to the filament axis that can be either inflows (increasing the filament mass) or outflows and (ii) longitudinal flows along the filament axis. The former case is seen in the Orion B data, while the latter is not identified. We have also identified asymmetrical flow patterns, usually associated with filaments located at the edge of an H II region.
Conclusions. This is the first observational study to highlight feedback from H II regions on filament formation and, thus, on star formation in the Orion B cloud. This simple statistical method can be used for any molecular cloud to obtain coherent information on the kinematics.
Vibrational relaxation of high levels of H2O by collisions with Ar as studied by infrared chemiluminescence
Authors: Butkovskaya N. I. , Setser D. W. 
Published: November 2022

Vibrational relaxation of H2O(v2,v13) molecules by collisions with Ar was studied at 298 K (v2 denotes the bending vibrational mode and v13 denotes the sum of the symmetric, v1, and asymmetric, v3, vibrational modes). The H2O molecules from 14 different exothermic reactions of H-atom abstraction by OH radicals were observed by infrared emission from a fast flow reactor as a function of Ar pressure and reaction time. Numerical kinetic calculations were used to obtain rate constants for stretch-to-bend energy conversion, (v2,v13) → (v2 + 2,v13 − 1), and pure bend relaxation, (v2,v13) → (v2 − 1,v13). Rate constants for states up to v13 = 4 were based on the average values from all reactions. The rate constant for the (2,0) → (1,0) bending relaxation is in agreement with the published values from laser-induced fluorescent experiments; the rate constants for higher levels increase with v2. Our average rate constant for the (0,1) → (2,0) stretch-to-bend conversion is somewhat smaller but falls within the uncertainty limit of the published value. The average rate constants for the stretch-to-bend process for (01), (02), (03), and (04) stretching states are (4.3 ± 0.8) × 10−14, (7.7 ± 1.1) × 10−14, (14.3 ± 4.2) × 10−14, and (20.6 ± 6.2) × 10−14 cm3 molecule−1 s−1, respectively.
Strong Coulomb coupling influences ion and neutral temperatures in atmospheric pressure plasmas
Authors: Acciarri M D , Moore C , Baalrud S D 
Published: November 2022

Abstract
Molecular dynamics simulations are used to model ion and neutral temperature evolution in partially-ionized atmospheric pressure plasma at different ionization fractions. Results show that ion–ion interactions are strongly coupled at ionization fractions as low as 10−5 and that the temperature evolution is influenced by effects associated with the strong coupling. Specifically, disorder-induced heating is found to rapidly heat ions on a timescale of the ion plasma period (∼10 s ps) after an ionization pulse. This is followed by the collisional relaxation of ions and neutrals, which cools ions and heats neutrals on a longer (∼ns) timescale. Slight heating then occurs over a much longer (∼100 s ns) timescale due to ion-neutral three-body recombination. An analytic model of the temperature evolution is developed that agrees with the simulation results. A conclusion is that strong coupling effects are important in atmospheric pressure plasmas.
Identification of the Kirkendall effect as a mechanism responsible for thermal decomposition of the InGaN/GaN MQWs system
Authors: Hrytsak Roman , Kempisty Pawel , Leszczynski Michal , Sznajder Malgorzata 
Published: November 2022

Abstract
A drop in the efficiency of light-emitting diodes based on InGaN/GaN QWs known as the ‘green gap’ has been studied intensively over the past dozen years. Several factors were revealed to contribute to its origin, such as random fluctuations in the indium concentration or the diffusion of point defects during the growth of QWs. The aim of this paper is to demonstrate that the Kirkendall effect can be the mechanism responsible for the thermal decomposition of InGaN/GaN MQWs structures, contributing to the green gap problem. By applying density functional theory, harmonic approximation, and harmonic transition state theory, we calculated the heights of the migration energy barriers of In and Ga atoms diffusing in

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alloys (

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), the vibrational frequencies of

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alloys in the presence of migrating point defects, the temperature dependencies of the defect migration energy barriers and diffusion coefficients of Ga and In atoms migrating in

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alloys. We demonstrated the presence of unbalanced diffusion rates of In and Ga atoms at the

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interfaces and finally explained the experimentally observed mechanism of void formation at the

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interfaces by means of the Kirkendall effect.