bluuebunny/crossref_metadata_2025_split huggingface dataset:
enrichMiR predicts functionally relevant microRNAs based on target collections
Authors: Soutschek Michael , Germade Tomás , Germain Pierre-Luc , Schratt Gerhard 
Published: May 2022

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that are among the main post-transcriptional regulators of gene expression. A number of data collections and prediction tools have gathered putative or confirmed targets of these regulators. It is often useful, for discovery and validation, to harness such collections to perform target enrichment analysis in given transcriptional signatures or gene-sets in order to predict involved miRNAs. While several methods have been proposed to this end, a flexible and user-friendly interface for such analyses using various approaches and collections is lacking. enrichMiR (https://ethz-ins.org/enrichMiR/) addresses this gap by enabling users to perform a series of enrichment tests, based on several target collections, to rank miRNAs according to their likely involvement in the control of a given transcriptional signature or gene-set. enrichMiR results can furthermore be visualised through interactive and publication-ready plots. To guide the choice of the appropriate analysis method, we benchmarked various tests across a panel of experiments involving the perturbation of known miRNAs. Finally, we showcase enrichMiR functionalities in a pair of use cases.
Belatacept rescue conversion in kidney transplant recipients with vascular lesions (Banff cv score &gt;2): a retrospective cohort study
Authors: Bertrand Dominique , Matignon Marie , Morel Antoine , Ludivine Lebourg , Lemoine Mathilde , Hanoy Mélanie , Roy Frank Le , Nezam Dorian , Hamzaoui Mouad , de Nattes Tristan , Moktefi Anissa , François Arnaud , Laurent Charlotte , Etienne Isabelle , Guerrot Dominique 
Published: May 2022

ABSTRACT

Background
Immunosuppression in kidney transplant recipients with decreased graft function and histological vascular changes can be particularly challenging. The impact of a late rescue conversion to belatacept on kidney graft survival in this context has never been studied.

Methods
We report a bicentric retrospective cohort study comparing a calcineurin inhibitor (CNI) to belatacept switch versus CNI continuation in 139 kidney transplant recipients with histological kidney vascular damage (cv ≥2, g + cpt ≤1, i + t ≤1) and low estimated glomerular filtration rate (≤40 mL/min/1.73 m²). Primary outcome was death-censored graft survival.

Results
During the study follow-up, 10 graft losses (14.5%) occurred in the belatacept group (n = 69) versus 26 (37.1%) in the matched CNI group (n = 70) (P = .005). Death-censored graft survival was significantly higher in the belatacept group (P = .001). At 3 years, graft survival was 84.0% in the belatacept group compared with 65.1% in the control group. Continuing CNI was an independent risk factor for graft loss [hazard ratio (HR) 3.46; P &lt; .005]. The incidence of cellular rejection after the conversion was low (4.3% in both groups) and not significantly different between groups (P = .84). Patients switched to belatacept developed significantly less donor-specific antibodies de novo. Belatacept was an independent risk factor for the occurrence of opportunistic infections (HR 4.84; P &lt; .005).

Conclusion
The replacement of CNI with belatacept in patients with decreased allograft function and vascular lesions is associated with an improvement in graft survival and represents a valuable option in a context of organ shortage. Caution should be exercised regarding the increased risk of opportunistic infection.
Poisson–Lie T-plurality for dressing cosets
Authors: Sakatani Yuho 
Published: May 2022

Abstract
The Poisson–Lie T-plurality is an equivalence of string theories on various cosets $\mathcal {D}/\tilde{G},\ \mathcal {D}/\tilde{G}^{\prime },\ldots$, where $\mathcal {D}$ is a Drinfel’d double and $\tilde{G}$, $\tilde{G}^{\prime },\ldots$ are maximal isotropic subgroups. This can be extended to the equivalence for dressing cosets, i.e., $F\backslash \mathcal {D}/\tilde{G},\ F\backslash \mathcal {D}/\tilde{G}^{\prime },\ldots$, where F is an isotropic subgroup of $\mathcal {D}$. We explore this extended Poisson–Lie T-plurality, clarifying the relation between several previous approaches. We propose a gauged sigma model for a general gauge group F and obtain the formula for the metric and the B-field on the dressing coset. Using this formula and an ansatz for the dilaton, we show that the Poisson–Lie (PL) T-plurality for dressing cosets (with spectator fields) is a symmetry of double field theory. The formula for the Ramond–Ramond field strength is also proposed such that the equations of motion for the Neveu–Schwarz–Neveu–Schwarz fields are transformed covariantly. In addition, we provide specific examples of the PL T-plurality for dressing cosets.
Quantifying the population burden of musculoskeletal disorders, including impact on sickness absence: analysis of national Scottish data
Authors: Walker-Bone Karen , Storkey Helen , Peacock Julie , Ellis Benjamin , Ly Michael , Hill Jonathan , O’Malley James 
Published: May 2022

Abstract

Objectives
Musculoskeletal disorders (MSDs) account for the greatest burden of years lived with disability globally. To prevent disability, good-quality services need to be commissioned, appropriate for local need. We analysed data collected systematically from a new musculoskeletal service serving 70% of the population of Scotland to evaluate: age- and sex-specific occurrence; anatomical distribution; and impact and effect on work ability.

Methods
A new centralized telephone-based triage for people with musculoskeletal disorders was set up in Scotland in 2015. Available to most of the population aged &gt;16 years (&gt;3 million people), data were collected systematically into a database detailing: anatomical site, nature of onset, duration, impact/risk (modified STarT score), deprivation level and, for those in employment, sickness absence.

Results
Data were available from 219 314 new callers, 2015–18. Calls were more frequently from women (60%), increased with age until the eighth decade, and 66% reported symptoms that had been present for &gt;6 weeks. Callers were more likely to be living in more deprived areas in each age band between 20 and 64 years and tended to have higher-impact symptoms. The majority (53%) of callers were in employment, and 19% of these were off sick because of their symptoms. Sickness absence was more common among those with highest impact/risk scores from deprived areas with more acute symptoms.

Discussion
Large-scale systematic data collection for MSDs emphasizes the size and impact of the burden among adults aged &gt;16 years. A socio-economic gradient is evident in terms of prevalence and impact of MSDs, particularly for sickness absence.
Triterpenes from Olea europaea modulate in vitro ruminal fermentation
Authors: Cangiano Lautaro R , Henry Darren D , Ciriaco Francine M , Quintela Jose Carlos , DiLorenzo Nicolas , Ipharraguerre Ignacio R 
Published: May 2022

Abstract
Bioactive compounds present in Olea europaea have shown promising antimicrobial potential as an alternative to conventional coccidiostats. These effects are exerted by triterpenic acids (TT) present in the olive plant, namely, oleanolic acid (OA), ursolic acid (UA), and maslinic acid (MA). The objective of this study was to determine the effects of OA, UA, and MA on in vitro ruminal fermentation in comparison with monensin (MON). The study consisted of two experiments conducted as randomized complete block designs using bahiagrass hay or a high-concentrate mixed ration as basal substrates. In the first experiment (Exp. 1), a batch culture was performed with increasing doses of OA, UA, or MA. In Exp. 2, to increase the solubility of OA, two chemical forms were evaluated: a sodium salt (OA-NA) or a phyto-phospholipid complex (OA-PHYT) at 0, 4, 40, 100, and 200 mg/L of incubation inoculum. In both experiments, the dose 0 was used as control (CTL) and monensin (MON) as a positive control. Data were analyzed as a randomized complete block design with a factorial arrangement of treatments. For Exp. 2, orthogonal polynomial contrasts, adjusted for unequal spacing were used to determine the linear effects of increasing doses of OA-NA and OA-PHYT. In Exp. 1, OA reduced the concentration of CH4 in the high-concentrate substrate compared with CTL (P = 0.04). In Exp. 2 the total gas production was linearly decreased with increasing doses of OA-NA in both substrates (P ≤ 0.02). Furthermore, OA-NA and OA-PHYT decreased in vitro organic matter digestibility (P &lt; 0.01) in the bahiagrass substrate to the same extent that MON did. However, the concentration of CH4/g of incubated DM was only reduced by the highest doses of OA-NA (P &lt; 0.02). Lastly, no effects were observed for total VFA nor the VFA profile; however, OA-NA linearly decreased the A:P ratio in the bahiagrass substrate (P = 0.03). In conclusion, the acid form of OA as well as the sodium salt and phyto-phospholipid complex of OA were able to modify some fermentation parameters in this study; however, the magnitude of the responses was lower compared with monensin. Future studies should test OA in vivo to determine if the effects on ruminal fermentation observed here can translate into improve production efficiency while reducing carbon emissions.
Functional Restoration of Complex Segmental Middle Third Facial Defect Using Tensor Fascia Lata and Lipofilling
Authors: Abd Al-Moktader Magdy A. , Ayad Wael , Ouf Mohamed Osama , Shoulkami Khalad , Youssif Sherif Hamdeno , Dahshan Hazem , Zayid Tarek 
Published: May 2022

Summary:
Composite defects in the middle third of the face have devastating effects on a patient’s life and social impacts. Several techniques have been described for the restoration of facial defects. The dynamic reconstruction of such defects mainly comprises a complex two-stage procedure and/or microsurgery, functional muscle transfer for restoration of facial animation, and filling the defects. A novel idea for the dynamic reconstruction of the complex segmental midfacial defects includes employing a fascial interposition graft to bridge the gap between the proximally innervated remnants of the facial muscle supplied by the facial nerve and the distal paralyzed perioral muscle, which is simultaneously combined with lipofilling to obtain a good contour and functional restoration.
Transretroperitoneal Pedicled Omental Flap for Coverage of Traumatic Sacral Defect: A Case Report
Authors: Bruce William J. , Olla Danielle R. , Feimster James W. , Woldanski Lauren M. , Hart Kyle D. , Reid Adam , Schwartz Bradley , Berry Nada N. 
Published: May 2022

Summary:
The greater omentum is a reliable choice for salvage soft-tissue reconstruction. Benefits include consistent anatomy, long pedicle length, and a high concentration of lymphatic tissue that is resistant to infection. We report the case of a 46-year-old man with a complex traumatic sacral wound resulting in severe limitation of reconstructive options. A pedicled greater omentum flap was transposed through the retroperitoneum via the lumbosacral triangle, resulting in durable soft-tissue coverage.
Closing the Gap: Training Experiences and Career Outcomes for Underrepresented Minorities in Plastic Surgery
Authors: Diatta Fortunay , Mellia Joseph A. , Morris Martin P. , Murphy Alexander I. , Onyekaba Ginikanwa , Mares Jason , McAuliffe Phoebe B. , Broach Robyn B. , Fischer John P. , Butler Paris D. 
Published: May 2022

Background:
The present study assesses training characteristics, scholastic achievements, and traditional career accomplishments of ethnically underrepresented in medicine (UIM) plastic and reconstructive surgery (PRS) faculty relative to non-UIM PRS faculty.

Method:
A cross-sectional analysis of core PRS faculty appointed to accredited United States residency training programs (n = 99) was performed.

Results:
Of the 949 US PRS faculty, a total of 51 (5.4%) were identified as UIM. Compared with non-UIM faculty, there were few differences when evaluating medical education, residency training, pursuit of advanced degrees, and attainment of subspecialty fellowship training. UIM faculty were more likely than non-UIM faculty to have graduated from a medical school outside the United States (25% versus 13%, P = 0.014). In addition, UIM faculty did not differ from non-UIM counterparts in traditional career accomplishments, including promotion to full professor, obtaining NIH funding, serving as program director, receiving an endowed professorship, appointment to a peer-reviewed editorial board, scholarly contributions (H-index and number of publications), and appointment to chief/chair of their division/department.

Conclusions:
The historical lack of ethnic diversity that comprise US academic PRS faculty persists. This study reveals that those UIM faculty who are able to obtain faculty appointments are equally successful in achieving scholastic success and traditional career accomplishments as their non-UIM counterparts. As we strive toward increasing representation of UIM physicians in academic plastic surgery, the field will benefit from efforts that promote a pipeline for underrepresented groups who traditionally face barriers to entry.
Opportunity Costs of Internal Promotions in Plastic Surgery: Are Women Given a Fair Shot?
Authors: Plana Natalie M. , Smith Kira L. , Hu Sophia , Xu Wen , Broach Robyn B. , Butler Paris D. , Lin Ines C. 
Published: May 2022

Background:
Academic advancement in plastic surgery necessitates creation of opportunities for rising faculty, which are pivotal for women in their efforts to close prominent gender gaps in higher ranks. We study positions of academic prestige that benefit from internal nomination as surrogates for opportunities afforded to men and women seeking leadership roles.

Methods:
We collected the following datapoints: authors of invited discussions published in Plastic and Reconstructive Surgery from 2010 to 2019; current editorial board members of representative plastic surgery journals; recipients of society-sponsored traveling fellowships; and directors of the American Board of Plastic Surgery. Public profiles for all authors and surgeons were referenced to confirm gender identification.

Results:
Seven-hundred ninety-seven plastic and reconstructive surgery discussions were included, 18% of which included female first or senior authorship. Seventy-one (9%) discussions listed a female senior author. Male and female senior authors were equally as likely to collaborate with a female first co-author (25% and 26%, respectively). Only 17% of invited authors contributed to 55% of discussion articles. Women occupied 19% of journal editorial board positions, though none were editors-in-chief. American Society of Reconstructive Microsurgery, American Society of Maxiliofacial Surgeons, American Society for Surgery of the Hand, and Plastic Surgery Foundation traveling fellowships were awarded to one (3%), four (7%), five (13%), and 141 (15%) female plastic surgeons, respectively. Women comprise 26% of directors of American Board of Plastic Surgery.

Conclusions:
Female representation in plastic surgery is rising, but it is not mirrored across appointed positions in academia. We should strive to support advancements that allow selected prestigious positions to more accurately reflect the gender distribution within the plastic surgery community.
Surgical Treatment Outcome of de Quervain’s Disease: A Systematic Review and Meta-analysis
Authors: Bosman Romy , Duraku Liron S. , van der Oest Mark J.W. , Hundepool C.A. , Rajaratnam Vaikunthan , Power D.M. , Selles Ruud W. , Zuidam J. Michiel 
Published: May 2022

Background:
Surgical release of the extensor retinaculum is performed as a treatment for de Quervain’s (DQ) disease when conservative treatment fails. In the literature, there is no consensus about the effectiveness of a surgical release in patients with DQ, the complication rate, or which type of incision is superior. Therefore, a systematic review and meta-analysis were conducted.

Methods:
A systematic search was performed in Embase, Medline Ovid, Web of Science Core Collection, Cochrane, and Google Scholar. Articles regarding surgical treatment of DQ disease that reported outcome and complications were included. We extracted exact values of visual analog scale scores and percentages of patients who experienced pain at follow-up. Complications assessed were (sub) luxation, superficial radial nerve injuries, wound infections, and scar problems.

Results:
Twenty-one studies with a total of 939 patients were included. Five percent of these patients (95% CI 1%–18%) did not show complete remission of pain at follow-up. When pooled, the mean reduction in visual analog scale scores was 5.7 (95% CI 5.3–6.1) on a 0–10 scale. No difference in outcome between different types of surgery or incisions was seen. Based on the meta-analysis, the pooled complication rate was 11% (95% CI 5%–22%).

Conclusions:
Five percent of patients still have residual pain after surgical release of the first extensor compartment. Surgery type, as well as the type of incision, did not affect outcome or complication. Thus, surgical release of the extensor retinaculum for DQ disease is an effective treatment, regardless of the type of surgery.
Liposuction and Controlled Compression Therapy Reduce the Erysipelas Incidence in Primary and Secondary Lymphedema
Authors: Karlsson Tobias , Hoffner Mattias , Brorson Håkan 
Published: May 2022

Background:
Skin infections are a recurring problem for people with lymphedema, and lymphedema has been proven to be the single most important risk factor for developing erysipelas in the leg. This study aimed to determine whether liposuction for late-stage lymphedema reduces the rate of erysipelas in lower extremity lymphedema.

Methods:
One-hundred twenty-four patients with a median age of 49 years who had liposuction and controlled compression therapy for lower extremity lymphedema were included. Excess volumes were calculated before and after surgery. Median preoperative and postoperative patient years at risk were 11 and 5 years, respectively.

Results:
With a total of 1680 preoperative person years at risk and 335 bouts of erysipelas experienced in 64 patients, the preoperative incidence rate was 0.20 bouts per person per year, and the period prevalence was 52%. Postoperatively, the patients were followed over a total of 763 person years at risk, and 28 patients experienced a total of 53 bouts of erysipelas, resulting in a postoperative incidence rate of 0.07 bouts per person per year, and a period prevalence of 23%. This represents a 65% decrease in the erysipelas incidence rate (P < 0.001). The preoperative median excess volume of 3158 ml was reduced with a median of 100% (P < 0.0001).

Conclusions:
Liposuction and controlled compression therapy significantly reduce the risk for erysipelas in lower extremity lymphedema and completely reduces the excess volume. This finding is similar to our previous research including patients with upper extremity lymphedema.
Rintala Flap and Posterior Perichondrial Cutaneous Graft: A Combined Approach for Nasal Tip Reconstruction
Authors: Eseme Ebai A. , Da Rocha Daniel , Tremp Mathias , Tzika Evangelia , Merat Rastine , Kalbermatten Daniel F. , Oranges Carlo M. 
Published: May 2022

Summary:
Nasal tip reconstruction requires a meticulous approach due to the complexity of the nasal anatomy and its aesthetic importance. Many procedures have been described to restore this aesthetic unit, including the paramedian forehead flap, which is one of the workhorse flaps. However, despite excellent final outcomes, this procedure may be refused by patients, due to its temporary conspicuous appearance possibly associated with serious psychological implications, and the need of multiple interventions. We aimed to present an approach combining the Rintala flap and the posterior perichondrial cutaneous graft as a valuable alternative to treat large nasal tip defects.
Association Between Serum Vitamin D Level and Rates of Structural and Functional Glaucomatous Progression
Authors: Lee Terry , Jammal Alessandro A. , Medeiros Felipe A. 
Published: May 2022

Précis:
In a retrospective cohort study, serum vitamin D levels were not associated with rates of structural or functional loss in glaucoma patients, suggesting that low vitamin D level is not a risk factor for progression.

Purpose:
To investigate the association between serum vitamin D level and rates of functional and structural glaucomatous loss over time.

Methods:
This study included 826 eyes of 536 glaucoma or suspect patients with an average follow-up of 4.8±1.9 years. All patients had at least 1 serum vitamin D measurement, and all eyes had at least 2 reliable standard automated perimetry (SAP) tests and 2 spectral-domain optical coherence tomography (SD OCT) tests with a minimum follow-up of 6 months. Multivariable linear mixed-effects models were used to estimate the association of vitamin D level with rates of change in SAP mean deviation (MD) and OCT retinal nerve fiber layer (RNFL) thickness over time while adjusting for potential confounding factors.

Results:
Patients had an average of 3.4±1.7 SAP tests, 4.8±1.9 SD OCT tests, and 2.3±1.9 vitamin D measurements. The average serum vitamin D level was 33.9±13.2 ng/mL. Mean rates of MD and RNFL change were −0.03±0.08 dB/y and −0.68±0.64 µm/y, respectively. After controlling for confounding factors, there was no statistically significant association between mean vitamin D level and rates of MD (β=0.038, 95% CI: −0.006, 0.082, P=0.09) or RNFL loss over time (β=−0.018, 95% CI: −0.092, 0.055, P=0.62).

Conclusions:
We did not find a significant association between vitamin D level and rates of visual field or RNFL loss over time in individuals with glaucoma and glaucoma suspect patients.
Iris Obstruction Following PRESERFLO™ Microshunt Implantation and Surgical Management
Authors: Trigaux Céline , Steindor Friedrich A. , Spaniol Kristina , Geerling Gerd , Borrelli Maria 
Published: May 2022

Purpose:
To present a case of lumen obstruction after implantation of microshunt with subconjunctival drainage and subsequent management.

Case Report:
A 56-year-old male with primary open angle glaucoma underwent uneventful PRESERFLO™ MicroShunt implantation in both eyes. Five months after surgery the patient presented with an intraocular pressure of 26▒mmHg in the right eye due to iris obstruction.

Results:
The iris fibers were severed and removed surgically to free the lumen. Follow-up showed a normalised intraocular pressure of 10▒mmHg and a free lumen.

Conclusion:
Uncontrolled intraocular pressure due to iris obstruction following PRESERFLO™ Microshunt was addressed by surgical removal of iris fibers at the lumen entrance without the need for tube repositioning.