bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer and cardiovascular outcomes after breast cancer in survivors of Hodgkin lymphoma
Authors: Krul Inge M. , Boekel Naomi B. , Kramer Iris , Janus Cécile P. M. , Krol Augustinus D. G. , Nijziel Marten R. , Zijlstra Josée M. , van der Maazen Richard W. M. , Roesink Judith M. , Jacobse Judy N. , Schaapveld Michael , Schmidt Marjanka K. , Opstal‐van Winden Annemieke W. J. , Sonke Gabe S. , Russell Nicola S. , Aleman Berthe M. P. , van Leeuwen Flora E. 
Published: October 2022

BackgroundHodgkin lymphoma (HL) survivors treated with chest radiotherapy have an increased risk of breast cancer (BC). Prior HL treatment and associated cardiovascular disease (CVD) risk may limit BC treatment options. It is unknown how treatment adaptations affect BC and CVD outcomes.MethodsThe authors compared 195 BC patients treated with chest/axillary radiotherapy for HL (BC‐HL) with 5988 age‐ and calendar year‐matched patients with first primary BC (BC‐1). Analyses included cumulative incidence functions and Cox regression models, accounting for tumor characteristics and BC treatment.ResultsCompared to BC‐1 patients, BC‐HL patients received anthracycline‐containing chemotherapy (23.7% vs. 43.8%, p < .001) and breast‐conserving surgery followed by radiotherapy (7.1% vs. 57.7%, p < .001) less often. BC treatment considerations were reported for 71% of BC‐HL patients. BC‐HL patients had a significantly higher risk of 15‐year overall mortality than BC‐1 patients (61% vs. 23%). Furthermore, risks of BC‐specific mortality and nonfatal BC events were significantly increased among BC‐HL patients, also when accounting for tumor and treatment characteristics (2.2‐ to 4.5‐fold). BC‐HL patients with a screen‐detected BC had a significantly reduced (61%) BC‐specific mortality. One‐third of BC‐HL patients had CVD at BC‐diagnosis, compared to <0.1% of BC‐1 patients. Fifteen‐year CVD‐specific mortality and CVD incidence were significantly higher in BC‐HL patients than in BC‐1 patients (15.2% vs. 0.4% and 40.4% vs. 6.8%, respectively), which was due to HL treatment rather than BC treatment.ConclusionsBC‐HL patients experience a higher burden of CVD and worse BC outcomes than BC‐1 patients. Clinicians should be aware of increased CVD risk when selecting BC treatment for HL survivors.Lay summary

Patients with breast cancer after Hodgkin lymphoma (BC‐HL) may have limited options for BC treatment, due to earlier HL treatment and an associated increased risk of cardiovascular disease (CVD).

BC treatment considerations were reported for 71% of BC‐HL patients.

We examined whether BC‐HL patients have a higher risk of CVD or BC events (recurrences/metastases) compared to patients with breast cancer that had no earlier tumors (BC‐1).

We observed a higher burden of CVD and worse BC outcomes in HL patients compared to BC‐1 patients.

Clinicians should be aware of increased CVD risk when selecting BC treatment for HL survivors.
Lignin‐derived carbon materials for catalysis and electrochemical energy storage
Authors: Wang Huan , Feng Pingxian , Fu Fangbao , Yu Xuefeng , Yang Dongjie , Zhang Wenli , Niu Li , Qiu Xueqing 
Published: October 2022

AbstractLignin is abundant in green biomass. However, most of the lignin remains to be utilized. Lignin‐derived carbons (LDCs) provide a feasible approach for lignin valorization. Owing to the coupling merits of low cost, tunable morphologies, and high porosity, LDC materials have drawn extensive attention in the fields of catalysis and electrochemical energy storage. This review summarizes the recent advances in LDC materials and their applications in catalysis, supercapacitors, and secondary batteries. The bottlenecks and future trends are proposed for the further development of advanced LDCs. This review is expected to guide the preparation of high‐value‐added LDCs.
Impact of improving severity of secondary mitral regurgitation on survival
Authors: Sannino Anna , Banwait Jasjit K. , Sudhakaran Sivakumar , Rahimighazikalayeh Gelareh , Szerlip Molly , Smith Robert , Esposito Giovanni , Mack Michael J. , Grayburn Paul A. 
Published: October 2022

AbstractAimsSecondary mitral regurgitation (SMR) is frequent in patients with heart failure with reduced ejection fraction (HFrEF) and portends detrimental prognosis. Despite interventions addressing the mitral valve (MV) have been proven effective to improve survival, an important knowledge gap exists regarding the role of medical therapy (MT) in this context. Thus, we aimed at investigating the role of MT optimization in patients with SMR and HFrEF.Methods and resultsA total of 435 patients with SMR and HFrEF were retrospectively evaluated. Of those, 158 with severe SMR were finally included, with 63 (40%) managed with MT alone and 96 (60%) with MV intervention plus MT. Echocardiography was performed after 30 days of MT optimization or MV intervention. Responders were patients with a final mitral regurgitation (MR) grade of ≤2+. Survival data were gathered through the National Database Index and patient chart review. MR severity improved in 131 patients (100% MV intervention; 57% MT) but stayed the same or worsened in 27 patients. Responders and non‐responders were similar for baseline characteristics. Overall, long‐term survival of responders was significantly higher than non‐responders [hazard ratio (HR) 0.55, 95% confidence interval (CI) (0.32–0.96), P = 0.032]. No difference in survival was observed when evaluated by intervention type in the overall population (MT alone, n = 63; MV intervention plus MT, n = 95) [HR 0.77, 95% CI (0.48–1.26), P = 0.3], nor within responder group (MT alone, n = 36; MV intervention plus MT, n = 95) [HR 1.03, 95% CI (0.56–1.89), P = 0.94].ConclusionsMT reduces SMR severity in 57% of the patients with severe SMR. A final SMR grade of ≤2+ is linked to improved survival, independently of the type of treatment they receive.
Optimal cardiometabolic health and risk of heart failure in type 2 diabetes: an analysis from the Look AHEAD trial
Authors: Patel Kershaw V. , Khan Muhammad Shahzeb , Segar Matthew W. , Bahnson Judy L. , Garcia Katelyn R. , Clark Jeanne M. , Balasubramanyam Ashok , Bertoni Alain G. , Vaduganathan Muthiah , Farkouh Michael E. , Januzzi James L. , Verma Subodh , Espeland Mark , Pandey Ambarish 
Published: October 2022

ABSTRACTAimsTo evaluate the contribution of baseline and longitudinal changes in cardiometabolic health (CMH) towards heart failure (HF) risk among adults with type 2 diabetes (T2D).Methods and resultsParticipants of the Look AHEAD trial with T2D and without prevalent HF were included. Adjusted Cox models were used to create a CMH score incorporating target levels of parameters weighted based on relative risk for HF. The associations of baseline and changes in the CMH score with risk of overall HF, HF with preserved (HFpEF) and reduced ejection fraction (HFrEF) were assessed using Cox models. Among the 5080 participants, 257 incident HF events occurred over 12.4 years of follow‐up. The CMH score included 2 points each for target levels of waist circumference, glomerular filtration rate, urine albumin‐to‐creatinine ratio, and 1 point each for blood pressure and glycated haemoglobin at target. High baseline CMH score (6–8) was significantly associated with lower overall HF risk (adjusted hazard ratio [HR], ref = low score (0–3): 0.31, 95% confidence interval [CI] 0.21–0.47) with similar associations observed for HFpEF and HFrEF. Improvement in CMH was significantly associated with lower risk of overall HF (adjusted HR per 1‐unit increase in score at 4 years: 0.80, 95% CI 0.70–0.91). In the ACCORD validation cohort, the baseline CMH score performed well for predicting HF risk with adequate discrimination (C‐index 0.70), calibration (chi‐square 5.53, p = 0.70), and risk stratification (adjusted HR [high (6–8) vs. low score (0–3)]: 0.35, 95% CI 0.26–0.46). In the Look AHEAD subgroup with available biomarker data, incorporating N‐terminal pro‐B‐type natriuretic peptide to the baseline CMH score improved model discrimination (C‐index 0.79) and risk stratification (adjusted HR [high (8–10) vs. low score (0–4)]: 0.18, 95% CI 0.09–0.35).ConclusionsAchieving target levels of more CMH parameters at baseline and sustained improvements were associated with lower HF risk in T2D.
A novel battery cooling system using nanofluids on MATLAB Simulink
Authors: Wankhede Sagar , Kamble Laxman V. 
Published: October 2022

AbstractThe battery pack is one of the crucial components in the creation of an electric car. Thus, its optimal and efficient functioning is of prime importance. Several issues are generated due to battery heating which may be fatal and can cause severe issues. The battery cooling system is one of the most effective ways to keep the battery pack at the ideal temperature for lithium‐ion cells to function properly. This article mainly focuses on MATLAB Simulink simulation‐based novel battery cooling system design using Nanofluids. In this simulation study, the employed nanofluids are compared mostly to ethylene glycol. The simulation findings demonstrated that employing nanofluid as the coolant cools the battery pack more quickly than using ethylene glycol. It was found that ethylene glycol can cool the battery pack within 480 seconds while with the use of nanofluids the battery pack was cooled in just 150 seconds considering the temperature cooling from 40°C to 25°C. The effective and fast cooling of Nanofluids is due to the higher value of thermal conductivity of the fluid which plays a major role in heat transfer. Thus, fluid properties mainly thermal conductivity must be focused upon and % concentration of nanoparticles in the base fluid must be increased to get more effective cooling.
Faculty fathers: Understanding the experiences of faculty men with children during the COVID‐19 pandemic
Authors: Blakewood Pascale Amanda , Ehrlich Suzanne , Hicks‐Roof Kristen 
Published: October 2022

AbstractTo effectively cultivate systems of equity, it is important to not only understand the experiences of those who are most affected by inequity but also of those who are in positions of power and privilege. This study explores how faculty men with children navigated the pandemic experience. Two major thematic findings emerged including ‘Not (as) Interrupted’ and ‘“I” feel supported’. These findings suggest that academic fathers may be emerging from the pandemic positioned differently than academic mothers. This research has implications for higher education administrators and faculty in the shaping of practice and policies aimed at equitably supporting faculty post‐pandemic.
The impact of stress associated with caring for patients with COVID‐19 on career decisions, resilience, and perceived self‐efficacy in newly hired nurses in Jordan: A cross‐sectional study
Authors: Al Hadid Lourance A. E. , Al Barmawi Marwa A. , Alnjadat Rafi , Farajat Lo'ai Al 
Published: October 2022

AbstractBackground and AimsThe decision to stay in nursing has been challenged by the recent coronavirus disease 2019 (COVID‐19) pandemic. New nurses joined the workforce and provided care to patients with COVID‐19 although they received limited training, which could have influenced their intention to stay in nursing. We aimed in this study to examine the impact of caring for patients with COVID‐19 on career decisions, resilience, and perceived self‐efficacy among newly hired nurses in Jordan. It also tested the predictors of intentions to stay among new nurses.MethodsThis cross‐sectional quantitative study was conducted using an online electronic questionnaire form. The sample included newly hired nurses (n = 300) working in public hospitals and providing care to patients with COVID‐19 in different levels of acuity units. The perceived stress scale and Connor−Davidson resilience scale 25 were used to measure stress and resilience among nurses.ResultsThe majority chose nursing as their career, but they were not satisfied with the current work conditions or autonomy in decision‐making. Many nurses reported having moderate to high work‐related stress and low to moderate resilience. Among all variables in this study, financial income predicted mild intention to stay in nursing.ConclusionsNurses expressed the presence of work‐related stress and low to moderate levels of resilience. As new nurses, exposure to these stress levels might lead to burnout. Nursing managers should take necessary measures to promote better work conditions and improve resilience to avoid nurses leaving the profession at times when there is a shortage.
Systemic circulating microRNA landscape in Lynch syndrome
Authors: Sievänen Tero , Korhonen Tia‐Marje , Jokela Tiina , Ahtiainen Maarit , Lahtinen Laura , Kuopio Teijo , Lepistö Anna , Sillanpää Elina , Mecklin Jukka‐Pekka , Seppälä Toni T. , Laakkonen Eija K. 
Published: October 2022

AbstractCirculating microRNAs (c‐miRs) are small noncoding RNA molecules that migrate throughout the body and regulate gene expression. Global c‐miR expression patterns (c‐miRnomes) change with sporadic carcinogenesis and have predictive potential in early detection of cancers. However, there are no studies that have assessed whether c‐miRnomes display similar potential in carriers of inherited pathogenic mismatch‐repair gene variants (path_MMR), known as Lynch syndrome (LS), who are predisposed to highly increased cancer risk. Using high‐throughput sequencing and bioinformatic approaches, we conducted an exploratory analysis to characterize systemic c‐miRnomes of path_MMR carriers, sporadic rectal cancer patients and non‐LS controls. We showed for the first time that cancer‐free path_MMR carriers have a systemic c‐miRnome of 40 differentially expressed c‐miRs that can distinguish them from non‐LS controls. The systemic c‐miRnome of cancer‐free path_MMR carriers also resembles the systemic c‐miRnomes of cancer patients with or without path_MMR. Our pathway analysis linked the found differentially expressed c‐miRs to carcinogenesis. A total of 508 putative target genes were identified for 32 out of 40 differentially expressed c‐miRs, and 238 of them were enriched in cancer‐related pathways. The most enriched c‐miR‐target genes include well‐known oncogenes and tumor suppressor genes such as BCL2, AKT3, PIK3CA, KRAS, NRAS, CDKN1A and PIK3R1. Taken together, our findings suggest that LS and sporadic carcinogenesis share common biological pathways and alterations in these pathways can produce a c‐miR signature which can track potential oncogenic stress in cancer‐free path_MMR carriers. Therefore, c‐miRs hold potential in monitoring the LS risk stratification patterns during clinical surveillance or cancer management.
Development of a smart IoT‐based drip irrigation system for precision farming
Authors: S Vinod Kumar , Singh Chandra Deep , Rao K. V. Ramana , Kumar Mukesh , Rajwade Yogesh Annand 
Published: October 2022

AbstractPrecision irrigation scheduling using real‐time sensors has the potential to boost water use efficiency while maximizing resource utilization. Traditional farming is adversely affected by improper resource management. To overcome a farmer's efforts, an IoT‐based drip irrigation system was developed and tested for system performance. It was compared with an ETc‐based drip irrigation system for brinjal crops grown in planter beds filled with vertisols. The developed system, consisting of sensors and microcontrollers, records the environmental parameters, namely, soil moisture content, soil temperature, and relative humidity and temperature. Irrigation scheduling was programmed using upper (field capacity) and lower thresholds (50% plant available water). Irrigation applications were triggered when the soil moisture value reached the lower threshold (33%) and ended after the field capacity was attained (46%). The information captured by the sensors is wirelessly uploaded to the cloud server using IoT technology, which can be accessed from anywhere in the world. It was observed that the IoT‐based drip irrigation testing plant grew 1.3 cm taller than the ETc‐based drip irrigation testing plant. The length and width of brinjal plant leaves also increased more than the ETc‐based drip irrigation treatments. The IoT‐based drip irrigation treatments improved pump operating time, leaf length and width by 85 min, 4.4 cm and 3.1 cm, respectively, compared to 125 min, 3.7 cm and 2.4 cm for the ETc‐based drip irrigation treatment. During a period of 31 days, water savings of 35% were observed compared to ETc‐based drip irrigation. The developed system was rugged, and a water‐resistant enclosure allowed its use in outdoor agriculture fields.
Review and evaluation of the role of a psychiatric pharmacist on medication management in a gender health program
Authors: Wartman Carolanne , Walroth Todd A. , Butterfield David , Anderson Lindsey , Peters Michael , Schmelz Andrew , Ott Carol 
Published: October 2022

AbstractIntroductionPeople who identify as transgender experience a significant amount of mental health concerns compared to the general population. Gender health programs offer the opportunity to provide comprehensive care for this highly stigmatized population, with the potential for psychiatric pharmacists to assist other providers and serve this need. This study aimed to evaluate the number and type of interventions made by a psychiatric pharmacist within a gender health program.MethodsA retrospective review of the electronic medical record was conducted analyzing mental health visits completed by psychiatric pharmacists within the Gender Health Program between May 1, 2020 and December 31, 2021. The primary outcome was number and type of interventions, defined as medication adjustments, laboratory monitoring, and completion of prior authorizations. Secondary outcomes included a description of medication regimens, number and type of patient education provided, and referrals to other healthcare professionals. Key subgroup analyses consisted of number of interventions based on gender identity, race identity, and insurance status.ResultsThere were a total of 152 appointments among 93 patients. Sixty‐one patients (66%) received at least one intervention [median (interquartile range, IQR) of 2 (2, 4)], which occurred across 81 pharmacist appointments (53%). Psychotropic medications were adjusted at 79 appointments (97%), with primarily medication initiations. Patient education was completed and documented at 102 appointments with a median (IQR) of 2 (1, 2) topics discussed per appointment. There was a statistically significant difference found between transmen and transwomen on number of interventions [31 (67%) vs 15 (45%), P = 0.048].ConclusionThe pharmacist in this study had the opportunity to bridge gaps in access to care to healthcare providers by initiating and managing medications, providing thorough education, and referring patients to further resources. This study affirms the accessibility and role of a psychiatric pharmacist on the interdisciplinary team caring for lesbian, gay, bisexual, transgender, queer or questioning, and more (LGBTQ+) patients.
A preliminary neuroimaging investigation of the effects of mindfulness training on attention reorienting and amygdala reactivity to emotional faces in adolescent and adult females
Authors: Dumontheil Iroise , Lyons Kristen E. , Russell Tamara A. , Zelazo Philip David 
Published: October 2022

AbstractIntroductionAdolescence is a time of increased emotional reactivity and improving cognitive control. Mindfulness meditation training may foster adolescents' cognitive control and emotional regulation skills; however little is known about the impact of mindfulness training in adolescents compared to adults. We examined the effect of mindfulness meditation versus a closely matched active control condition (relaxation training) on behavioral and neural measures of cognitive control and emotional reactivity in a small group of adolescents and adults.MethodsStructural and functional magnetic resonance imaging data were collected before and after 8 weeks of training in 26 adolescent (12–14 years) and 17 adult (23–33 years) female participants in the United Kingdom while they completed an n‐back task with emotional face distractors and an attentional control task. Participants of each group chose a class date/time and the classes were then randomly allocated to mindfulness or relaxation conditions.ResultsCompared to relaxation training, mindfulness training led to an increase in the speed of reorienting attention across age groups. In addition, there was preliminary evidence for reduced amygdala response to emotional face distractors in adolescents after mindfulness training.ConclusionsAn 8‐week mindfulness program showed similar facilitative effects in adolescent and adult females on the reorienting of attention, a skill that is repeatedly practiced during mindfulness meditation. Mindfulness also reduced left amygdala reactivity to emotional face distractors in adolescents only. Mindfulness meditation practice can therefore have a facilitative effect on female adolescents' attentional control, and possibly attenuate their emotional reactivity.
Intimate partner violence among adolescents: Prevalence rates after one decade of research
Authors: Muñoz‐Rivas Marina J. , Redondo Natalia , Olmos Ricardo , Ronzón‐Tirado Román 
Published: October 2022

AbstractIntroductionIntimate partner violence research and intervention strategies have grown substantially over the last two decades. However, little research has examined whether the intimate partner prevalence has changed or remained stable over time in Spain. Moreover, few studies have analyzed whether intimate partner violence prevalence rates among genders and age groups have fluctuated similarly or not.MethodThe aim of this study was to analyze the trends observed in intimate partner violence perpetration and victimization rates among adolescents in three sample cohorts from Spain interviewed in 2006, 2010, and 2016 (4591 Spanish adolescents; 53.6% girls and 46.2% boys). ANCOVA was used to compare the population means between the cohorts: sex, age, and the type of intimate partner violence, for example, verbal, physical, and sexual.ResultsThe results showed a significant decrease in intimate partner violence rates from 2006 to 2016, which was more noticeable within the first half of this decade. Throughout the decade, the girls perpetrated more verbal and mild physical assaults, while the boys perpetrated more sexual assaults. However, these results suggest a clear bidirectional intimate partner violence dynamic between the genders. Additionally, late adolescence reported a higher prevalence of aggressions.ConclusionsThe results highlight the need to adapt current prevention strategies considering the differences in the intimate partner violence trajectories based on sex and age, with the aim of regaining the marked rate of decline in aggression observed up to 2010.
“Deep approaches to learning” in a project‐based nanofabrication graduate course
Authors: Tang Mary , Kommera Swaroop , Raghuram Usha , Rincon Michelle , Xu Xiaoqing , Fan Jonathan , Howe Roger T. 
Published: October 2022

AbstractWe describe a graduate‐level, laboratory course that is structured as a “master class” in experimental research project planning and execution. Students work in teams to engage in project topics of their choosing, ideally relevant to their own areas of research, that make use of the university's shared fabrication and characterization facilities. After developing their project plans, which includes a schedule, budget, and milestones, students execute them under the guidance of their mentors. The aim of the course is that the students develop deep conceptual knowledge of the practice of experimental science, with regard to: project planning and execution, effective communication and teamwork, technical rigor, and peer review. Because students learn by applying these skills to topics that are personally relevant to them, this course can be described as using on deep approaches to learning.