bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PENGARUH PRODUK DOMESTIK BRUTO (PDB), INVESTASI MODAL MANUSIA, INFLASI DAN PERTUMBUHAN PENDUDUK TERHADAP KEMISKINAN ANTAR PROVINSI DI INDONESIA TAHUN 2015-2019
Authors: Rahma Nur , Gamsir Gamsir , Rumbia Wali Aya , Ernawati Ernawati 
Published: November 2022

Menurunnya persentase kemiskinan di Indonesia maupun antar provinsi selama kurun waktu 5 tahun yaitu tahun 2015-2019 menjadi sebuah fenomena yang sangat langka. Biasanya banyak orang yang mengetahui bahwa baik persentase maupun jumlah penduduk miskin cenderung mengalami peningkatan di setiap tahuunya. Penelitian ini bertujuan untuk menganalisis pengaruh Produk Domestik Bruto (PDB), Investasi Modal Manusia, Inflasi dan Pertumbuhan Penduduk terhadap Kemiskinan antar provinsi di Indonesia. Jenis data yang digunakan dalam penelitian ini adalah jenis data kuantitatif dengan data sekunder yang diperoleh dari Badan Pusat Statistik (BPS). sampel penelitian ini adalah 34 provinsi. Penelitian ini menggunakan data panel (pooled data) yakni menggabungkan data time series dan cross section selama 5 tahun yaitu mulai dari tahun 2015-2019 di Indonesia. Metode analisis data yang digunakan dalam penelitian ini adalah metode analisis data Regresi Data Panel dengan alat analisis E-views 10. Hasil penelitian menunjukkan bahwa:Produk Domestik Bruto (PDB) terhadap kemiskinan menunjukkan nilai negatif dan signifikan, Investasi Modal Manusia berpengaruh negatif dan signifikan terhadap kemiskinan, Inflasi berpengaruh positif dan signifikan terhadap kemiskinan, Pertumbuhan penduduk tidak berpengaruh signifikan terhadap kemiskinan di Indonesia. Kata Kunci: Kemiskinan, Produk Domestik Bruto, Investasi Modal Manusia, Inflasi, Pertumbuhan Penduduk
Electromagnetic characteristics of in vivo nerve fibers at the terahertz-far-infrared band
Authors: Guo Lianghao , Xu Duo , Wang Kaicheng , Sun Yuankun , Zhang Qin , Ning Hui , Lu Chang , Wang Shaomeng , Gong Yubin 
Published: November 2022

How terahertz signals perform in the neural system has attracted widespread interest in the life sciences community. Relevant experimental reveals that in animal nerve cells, the myelin sheath of the nerve axon has a higher refractive index than the intracellular and extracellular fluids in the Terahertz-far-infrared (THz-FIR) frequency band. This makes THz-FIR wave transmission possible in nerve fibers. Based on this premise, this article carries out the following work from the theoretical level to investigate the electromagnetic (EM) characteristics of in vivo nerve fibers at the THz-FIR band. First, the EM transmission model of the nerve fibers is established and studied theoretically. The dispersion curves of THz-FIR wave modals transmission in nerve fibers are calculated, which predict that nerve fibers can act as dielectric waveguides for transmitting THz-FIR waves and the THz-FIR waves can transmit at speeds up to 108 m/s. Second, a mode matching algorithm is proposed, which is named RNMMA, to calculate the transmission characteristics of THz-FIR waves at the nodes of Ranvier. The scattering matrix obtained from the proposed algorithm is in good agreement with the results from EM simulation software, which reveals how THz-FIR signals are transmitted forward through the nodes of Ranvier with low loss.
Rictor maintains endothelial integrity under shear stress
Authors: Li Hui , Zhou Wen-Ying , Liu Yi-Xian , Xia Yi-Yuan , Xia Chun-Lei , Pan Dao-Rong , Li Zheng , Shi Yi , Chen Shao-Liang , Zhang Jun-Xia 
Published: November 2022

Background: Endothelial injury induced by low shear stress (LSS) is an initiating factor in the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, and thrombotic diseases. Low shear stress activates the mammalian target of rapamycin complex 2 (mTORC2) signaling pathway. Rictor, the main constituent protein of mTORC2, is involved in vascular development. However, the impact of conditional Rictor ablation on endothelial homeostasis, especially on endothelial-specific markers, such as vascular endothelial-cadherin (VE-cadherin) and von Willebrand factor (VWF), under blood flow stimulation is unclear.Objective: We aimed to investigate whether endothelial Rictor is involved in maintaining vascular endothelial integrity and the potential role of Rictor in atheroprone blood flow-mediated endothelial injury.Methods and results: Immunofluorescence staining showed that endothelial Rictor was successfully knocked out in a mouse model. Scanning electron microscopy (EM) detection revealed disruption of the endothelial monolayer in the thoracic aorta of Rictor-deficient mice. Furthermore, scanning electron microscopy and transmission electron microscopy showed that Rictor deletion disrupted endothelial integrity and expanded cell junctions in the left common carotid artery region. In vitro, low shear stress disrupted actin filament polarity and the promoted the translocation of vascular endothelial-cadherin, the key component of adherens junctions (AJs) in human umbilical vein endothelial cells. After Rictor downregulation by small interfering RNA, the translocation of vascular endothelial-cadherin and stress fibers increased. Rictor knockdown inhibited low shear stress-induced von Willebrand factor upregulation, and downregulation of vascular endothelial-cadherin decreased low shear stress-induced von Willebrand factor expression. These results suggest that vascular endothelial-cadherin/von Willebrand factor is a possible mechanism mediated by Rictor in the pathological process of low shear stress-induced endothelial injury.Conclusion: Rictor is a key protein that regulates endothelial integrity under vascular physiological homeostasis, and Rictor mediates low shear stress-induced endothelial injury by regulating adherens junctions and von Willebrand factor.
Unusual combination of acute aortic dissection, Mayer-Rokitansky-Küster-Hauser syndrome, and 46,XX gonadal dysgenesis: A case report
Authors: Zeng Yifan , Hu Yerong , Jiang Bo , Tan Ling , Tang Hao 
Published: November 2022

BackgroundAcute Stanford type A aortic dissection (ATAAD) is a life-threatening disease. Elderly patients are the high-risk population for aortic dissection (AD). Young patients with AD usually have heritable connective tissue diseases such as Marfan syndrome and Loeys-Dietz syndrome. However, young AD patients without heritable connective tissue disease are relatively rare.Case presentationHerein, we report a case of a 25-year-old female diagnosed with ATAAD accompanied by undeveloped secondary sexual characteristics. Computed tomography angiography (CTA) showed that her AD involved the ascending and abdominal aorta. She had undergone thoracic endovascular aortic stent graft implantation in a local hospital due to acute Stanford type B aortic dissection at age 19. No uterus or ovaries were found on CTA and transabdominal ultrasonography. Sex hormone detection revealed a low estrogen level. G-banded karyotyping analyses revealed a normal 46,XX karyotype. Finally, her abnormalities in the reproductive system were diagnosed as MRKH syndrome and 46,XX gonadal dysgenesis. Whole-exome sequencing (WES) in the patient found an SNP variant of ACTA2 c.773G&gt;A and MYH11 c.5081A&gt;G. MYH11 c.5081A&gt;G was also found in her mother and younger brother. Copy number variations sequencing (CNV-seq) found an approximately 109.30 Kb duplication at chromosome 6p22.3 (Chr 6: g.24920238–25029535) with a copy number of 3. We performed emergent total aortic arch replacement with frozen elephant trunk surgery, and the patient recovered well after surgery. However, her abdominal AD was stilling progression during 6 months of follow-up.ConclusionTo our knowledge, we report the world's first case of early-onset recurrent AD combined with MRKH syndrome and 46,XX gonadal dysgenesis.
Predictive nomogram for coronary heart disease in patients with type 2 diabetes mellitus
Authors: Xiao Shucai , Dong Youzheng , Huang Bin , Jiang Xinghua 
Published: November 2022

ObjectiveThis study aimed to identify risk factors for coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM), build a clinical prediction model, and draw a nomogram.Study design and methodsCoronary angiography was performed for 1,808 diabetic patients who were recruited at the department of cardiology in The Second Affiliated Hospital of Nanchang University from June 2020 to June 2022. After applying exclusion criteria, 560 patients were finally enrolled in this study and randomly divided into training cohorts (n = 392) and validation cohorts (n = 168). The least absolute shrinkage and selection operator (LASSO) is used to filter features in the training dataset. Finally, we use logical regression to establish a prediction model for the selected features and draw a nomogram.ResultsThe discrimination, calibration, and clinical usefulness of the prediction model were evaluated using the c-index, receiver operating characteristic (ROC) curve, calibration chart, and decision curve. The effects of gender, diabetes duration, non-high-density lipoprotein cholesterol, apolipoprotein A1, lipoprotein (a), homocysteine, atherogenic index of plasma (AIP), nerve conduction velocity, and carotid plaque merit further study. The C-index was 0.803 (0.759–0.847) in the training cohort and 0.775 (0.705–0.845) in the validation cohort. In the ROC curve, the Area Under Curve (AUC) of the training set is 0.802, and the AUC of the validation set is 0.753. The calibration curve showed no overfitting of the model. The decision curve analysis (DCA) demonstrated that the nomogram is effective in clinical practice.ConclusionBased on clinical information, we established a prediction model for CHD in patients with T2DM.
Both J- and L-shaped upper hemisternotomy approaches are suitable for total arch replacement with frozen elephant trunk in patients with Type A dissection
Authors: Yang Zhonglu , Jiang Hui , Liu Yu , Ge Yuguang , Wang Huishan 
Published: November 2022

BackgroundMinimally invasive total arch replacement (TAR) with frozen elephant trunk (FET) implantation can be carried out through J-, L-, and inverted T-shaped upper ministernotomy. L- and inverted T-shaped upper ministernotomy are selected mostly for their better surgical view compared to J-shaped. However, few studies have paid attention to the difference in clinical effects between J- and L-shaped upper hemisternotomy in acute Type A aortic dissection (ATAAD).Materials and methodsWe retrospectively analyzed 74 consecutive patients with ATAAD who underwent TAR with FET implantation between December 2019 and October 2020. Patients were divided into the L group (n = 31, L-shaped upper hemisternotomy) and the J group (n = 43, J-shaped upper hemisternotomy). Perioperative characteristics were recorded.ResultsNo significant difference was found in any of the pre-operative, post-operative, or follow-up variables between the two groups. However, the CPB establishment time in the J group was significantly shorter than that in the L group (65.0 ± 17.9 min vs. 77.9 ± 17.2 min, P &lt; 0.05). Other intraoperative variables showed no significant difference.ConclusionTotal arch replacement with frozen elephant trunk implantation is feasible and can be carried out safely through J-shaped or L-shaped incision. A J-shaped incision might be beneficial for single incision, while an L-shaped incision might be beneficial if an extra incision is required to achieve better artery perfusion.
Strength and seismic anisotropy of textured FeSi at planetary core conditions
Authors: Kolesnikov E. , Kupenko I. , Achorner M. , Plückthun C. , Liermann H.-P. , Merkel S. , Sanchez-Valle C. 
Published: November 2022

Elastic anisotropy of iron-bearing alloys and compounds can lead to a variation of seismic velocities along different directions in planetary cores. Understanding the deformation properties of candidate core-forming materials is thus necessary to reveal the details about the interior of distant planets. Silicon has been considered to be one of the dominant light elements in the cores. Here we investigated the deformation of the ε-FeSi phase up to 49 GPa and 1100 K employing the radial X-ray diffraction technique in diamond anvil cells. Stoichiometric FeSi is a good approximation for the deformation behavior of the Fe-FeSi system and the low-pressure polymorph of FeSi may be the stable phase in the cores of small terrestrial planets such as Mercury. Yield strength in ε-FeSi is higher than in hcp-Fe and hcp-Fe-Si alloys, in the temperature range we investigated here the temperature has little influence on the lattice strain parameters, yield strength, and anisotropy within experimental precision. The azimuthal anisotropy of the longitudinal sound waves in ε-FeSi is below 0.6% at low pressure and decreases further with compression, while the shear wave contrast is below 1.25% in the entire investigated pressure range. Therefore, polycrystalline aggregates of iron silicide are nearly isotropic at extreme conditions. Consequently, any observed anisotropy in planetary cores will be incompatible with silicon being the dominant light element in the core composition.
Oocyte phenotype, genetic diagnosis, and clinical outcome in case of patients with oocyte maturation arrest
Authors: Zhu Lixia , Yang Qiyu , Jin Huizi , Zhou Juepu , Wang Meng , Yang Liu , Li Zhou , Qian Kun , Jin Lei 
Published: November 2022

Backgroundoocyte maturation arrest (OMA) is currently one of the major causes of in vitro fertilization (IVF) failure, and several gene mutations were found to be associated with OMA. The purpose of this study was to identify the oocyte phenotype, genetic diagnosis, and clinical outcomes of patients with OMA and explore their possible interrelationships, thus providing a more individualized and efficient treatment strategy guidance accordingly.MethodsA retrospective study was conducted, involving 28 infertile women with OMA in the Reproductive Medicine Center of Tongji Hospital from 2018 to 2021. Whole-exome sequencing was performed for the detection of gene mutations. Patients were classified into three groups based on their oocyte phenotype, and for each group, the immature oocytes were cultured in vitro and mature oocytes were fertilized to evaluate both the maturation capacity and developmental potential. The clinical outcomes of OMA patients with different gene mutations or from different groups were further analyzed and compared.ResultsTwenty-eight women with OMA were evaluated in this study. According to the stage of OMA, 14 (50.0%) women were classified as OMA Type-1 (GV arrest), 5 (17.9%) were OMA Type-2 (MI arrest), and 9 (32.1%) were OMA Type-3 (with both GV and MI arrest). Immature oocytes from OMA patients exhibited significantly lower maturation rates even after IVM, compared to those in general patients. Seven patients (25.0%) were detected to have deleterious variations in two genes (PATL2 and TUBB8), known to be associated with the OMA phenotype. Patients with identified mutations were found to have little opportunity to obtain offspring with their own oocytes. Among the patients without mutations identified, those classified as OMA Type-1 or Type-3 still had a chance to obtain offspring through IVF or natural pregnancy, while all patients in the Type-2 group failed to obtain live birth.ConclusionsThree different phenotypes were observed in patients with OMA. The clinical outcomes of patients were associated with the presence of gene mutations and the classification of oocyte phenotype, thus a reasonable triage system was proposed to optimize the allocation of health care resources and maximize patient benefit.
Syndromic and non-syndromic etiologies causing neonatal hypocalcemic seizures
Authors: Huang Yi-Chieh , Chao Yin-Chi , Lee Inn-Chi 
Published: November 2022

BackgroundThe diagnosis of neonatal hypocalcemic seizures (HS) in newborns is made based on clinical signs and serum calcium level. Their etiology is broad and diverse, and timely detection and initiation of treatment is essential.MethodsWe retrospectively reviewed 1029 patients admitted to the neonatal intensive care unit. Neonatal HS were diagnosed in 16 patients, and we compared etiologies and clinical outcomes, including clinical seizures and neurodevelopment at least over 1 year old.ResultsThe etiologies can be broadly categorized into 5 syndromic and 11 non-syndromic neonatal HS. Syndromic neonatal HS included 3 Digeorge syndrome, 1 Kleefstra syndrome and 1 Alström syndrome. Non-syndromic neonatal HS included 8 vitamin D deficiency, 1 hypoparathyroidism, and 2 hypoxic-ischemic encephalopathy. Patients with syndromic neonatal HS were found to have worse clinical outcomes than those with nonsyndromic HS. In eight patients with vitamin D deficiency, neurodevelopment was normal. Five of five patients (100%) with syndromic HS used two or more antiseizure drugs. However, among patients with non-syndromic neonatal HS, only one of 11 (9.1%) used more than one drug (p = 0.001).ConclusionThis finding highlighted that syndromic hypocalcemic seizures in newborns have worse neurodevelopmental outcomes and are more often difficult to manage, and would benefit from a genetic diagnostic approach.
Analysis of the spatial and temporal heterogeneity of factors influencing CO2 emissions in China’s construction industry based on the geographically and temporally weighted regression model: Evidence from 30 provinces in China
Authors: Li Tiantian , Gao Haidong , Yu Jing 
Published: November 2022

With the rapid economic development in recent years, China has increased its investment in infrastructure construction, and the construction industry has become a significant contributor to China’s carbon dioxide (CO2) emissions. Therefore, carbon emission reduction in the construction industry is crucial to achieving the goal of “carbon peaking and carbon neutrality” as soon as possible. However, few studies have investigated the factors influencing CO2 emissions from the construction industry in terms of spatial and temporal differences. To address this gap, we first improve the calculation method for the construction industry’s life-cycle assessment (LCA). The geographically and temporally weighted regression (GTWR) model is then utilized to provide insight into the spatio-temporal heterogeneity of the various factors influencing CO2 emissions across other regions and times. The results show that: 1) CO2 emissions from the construction industry in China increased rapidly from 576.5 million tons (Mt) in 2004–3,230 Mt in 2012 and then gradually decreased to 1998.51 Mt in 2020; indirect CO2 emissions accounted for more than 90% of the total CO2 emissions after 2008. 2) There is a solid global positive correlation between CO2 emissions from the construction industry in China during most of the time, and the spatial distribution of CO2 emissions shows a northeast-southwest pattern, with the center of gravity gradually shifting from central China to the southwest. 3) Economic output and industrial agglomeration are positive factors for the increase of CO2 emissions from the construction industry; and urbanization level, production efficiency, and energy efficiency are inhibiting factors for the increase of CO2 emissions from the construction industry. But the contribution and trend of each influencing factor differed significantly across time and regions, showing substantial spatial and temporal heterogeneity. Our findings provide a scientific basis for the Chinese government to implement a regional carbon reduction strategy for the construction industry.
Multiple stressor effects of a heatwave and a herbicide on zooplankton communities: Implications of global climate change
Authors: Roth Sabrina K. , Polazzo Francesco , García-Astillero Ariadna , Cherta Laura , Sobek Anna , Rico Andreu 
Published: November 2022

Aquatic ecosystems are exposed to pesticides through various pathways such as spray-drift, agricultural runoff, and chemical spills. Understanding the impact of pesticides on freshwater ecosystems requires not only understanding how pesticides affect aquatic organisms but also knowledge of their interactions with other stressors, such as those related to global climate change. Heatwaves are extended periods of temperature increase relative to the climatological mean. They are increasing in frequency and magnitude and pose an emerging threat to shallow freshwater ecosystems. In this study, we evaluated the single and combined effects of the herbicide terbuthylazine and a simulated heatwave on freshwater zooplankton communities using indoor microcosms. Terbuthylazine was applied at an environmentally relevant concentration (15 µg/L). The heatwave consisted of an increase of 6°C above the control temperature for a period of 7 days. When applied individually, the heatwave increased the total abundance of zooplankton by 3 times. The terbuthylazine exposure led to an indirect effect on the zooplankton community structure, reducing the relative abundance of some taxa. The combination of the heatwave and terbuthylazine had no significant impact on the zooplankton community, indicating additive effects dominated by the herbicide. The interaction between the two stressors increased chlorophyll-a concentrations and apparently changed the structure of the phytoplankton community, which may have benefitted cyanobacteria over green algae. Overall, this study shows that understanding the effects of chemical and non-chemical stressors on aquatic communities remains a challenging task. Further studies should be conducted to improve our mechanistic understanding of multiple stressor interactions at different levels of biological organisation.
Examining the effects of Salmonella phage on the caecal microbiota and metabolome features in Salmonella-free broilers
Authors: Lorenzo-Rebenaque Laura , Casto-Rebollo Cristina , Diretto Gianfranco , Frusciante Sarah , Rodríguez Juan Carlos , Ventero María-Paz , Molina-Pardines Carmen , Vega Santiago , Marin Clara , Marco-Jiménez Francisco 
Published: November 2022

Bacteriophages selectively infect and kill their target bacterial host, being a promising approach to controlling zoonotic bacteria in poultry production. To ensure confidence in its use, fundamental questions of safety and toxicity monitoring of phage therapy should be raised. Due to its high specificity, a minimal impact on the gut ecology is expected; however, more in-depth research into key parameters that influence the success of phage interventions has been needed to reach a consensus on the impact of bacteriophage therapy in the gut. In this context, this study aimed to investigate the interaction of phages with animals; more specifically, we compared the caecum microbiome and metabolome after a Salmonella phage challenge in Salmonella-free broilers, evaluating the role of the phage administration route. To this end, we employed 45 caecum content samples from a previous study where Salmonella phages were administered via drinking water or feed for 24 h from 4, 5 to 6-weeks-old broilers. High-throughput 16S rRNA gene sequencing showed a high level of similarity (beta diversity) but revealed a significant change in alpha diversity between broilers with Salmonella-phage administered in the drinking water and control. Our results showed that the phages affected only a few genera of the microbiota’s structure, regardless of the administration route. Among these, we found a significant increase in Streptococcus and Sellimonas in the drinking water and Lactobacillus, Anaeroplasma and Clostridia_vadinBB60_group in the feed. Nevertheless, the LC-HRMS-based metabolomics analyses revealed that despite few genera were significantly affected, a substantial number of metabolites, especially in the phage administered in the drinking water were significantly altered (64 and 14 in the drinking water and feed groups, respectively). Overall, our study shows that preventive therapy with bacteriophages minimally alters the caecal microbiota but significantly impacts their metabolites, regardless of the route of administration.