bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly luminescent scintillating hetero-ligand MOF nanocrystals with engineered Stokes shift for photonic applications
Authors: Perego J. , Bezuidenhout Charl X. , Villa I. , Cova F. , Crapanzano R. , Frank I. , Pagano F. , Kratochwill N. , Auffray E. , Bracco S. , Vedda A. , Dujardin C. , Sozzani P. E. , Meinardi F. , Comotti A. , Monguzzi A. 
Published: June 2022

AbstractLarge Stokes shift fast emitters show a negligible reabsorption of their luminescence, a feature highly desirable for several applications such as fluorescence imaging, solar-light managing, and fabricating sensitive scintillating detectors for medical imaging and high-rate high-energy physics experiments. Here we obtain high efficiency luminescence with significant Stokes shift by exploiting fluorescent conjugated acene building blocks arranged in nanocrystals. Two ligands of equal molecular length and connectivity, yet complementary electronic properties, are co-assembled by zirconium oxy-hydroxy clusters, generating crystalline hetero-ligand metal-organic framework (MOF) nanocrystals. The diffusion of singlet excitons within the MOF and the matching of ligands absorption and emission properties enables an ultrafast activation of the low energy emission in the 100 ps time scale. The hybrid nanocrystals show a fluorescence quantum efficiency of ~60% and a Stokes shift as large as 750 meV (~6000 cm−1), which suppresses the emission reabsorption also in bulk devices. The fabricated prototypal nanocomposite fast scintillator shows benchmark performances which compete with those of some inorganic and organic commercial systems.
Electrochemically driven regioselective C−H phosphorylation of group 8 metallocenes
Authors: Zheng Hao , Liu Chang-Hui , Guo Shi-Yu , He Gu-Cheng , Min Xiang-Ting , Zhou Bo-Chao , Ji Ding-Wei , Hu Yan-Cheng , Chen Qing-An 
Published: June 2022

AbstractMetallocenes are privileged backbones for synthesis and catalysis. However, the direct dehydrogenative C−H functionalization of unsymmetric metallocenes suffers from reactivity and selectivity issues. Herein, we report an electrochemically driven regioselective C−H phosphorylation of group 8 metallocenes. Mechanistic investigations indicate this dehydrogenative cross coupling occurs through an electrophilic radical substitution of the metallocene with a phosphoryl radical, facilitated by the metallocene itself. This work not only offers an efficient and divergent synthesis of phosphorylated metallocenes, but also provides a guide to interpret the reactivity and regioselectivity for the C−H functionalization of unsymmetric metallocenes.
Secondary through-space interactions facilitated single-molecule white-light emission from clusteroluminogens
Authors: Zhang Jianyu , Alam Parvej , Zhang Siwei , Shen Hanchen , Hu Lianrui , Sung Herman H. Y. , Williams Ian D. , Sun Jianwei , Lam Jacky W. Y. , Zhang Haoke , Tang Ben Zhong 
Published: June 2022

AbstractClusteroluminogens refer to some non-conjugated molecules that show visible light and unique electronic properties with through-space interactions due to the formation of aggregates. Although mature and systematic theories of molecular photophysics have been developed to study conventional conjugated chromophores, it is still challenging to endow clusteroluminogens with designed photophysical properties by manipulating through-space interactions. Herein, three clusteroluminogens with non-conjugated donor-acceptor structures and different halide substituents are designed and synthesized. These compounds show multiple emissions and even single-molecule white-light emission in the crystalline state. The intensity ratio of these emissions is easily manipulated by changing the halide atom and excitation wavelength. Experimental and theoretical results successfully disclose the electronic nature of these multiple emissions: through-space conjugation for short-wavelength fluorescence, through-space charge transfer based on secondary through-space interactions for long-wavelength fluorescence, and room-temperature phosphorescence. The introduction of secondary through-space interactions to clusteroluminogens not only enriches their varieties of photophysical properties but also inspires the establishment of novel aggregate photophysics for clusteroluminescence.
FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion
Authors: Li Shuaifeng , Han Shixun , Zhang Qi , Zhu Yibing , Zhang Haitao , Wang Junli , Zhao Yang , Zhao Jianhui , Su Lin , Li Li , Zhou Dawang , Ye Cunqi , Feng Xin-Hua , Liang Tingbo , Zhao Bin 
Published: June 2022

AbstractMitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 (FUNDC2) is transcriptionally upregulated in primary mouse liver tumors, and in approximately 40% of human hepatocellular carcinoma (HCC). Importantly, elevated FUNDC2 expression inversely correlates with patient survival, and its knockdown inhibits liver tumorigenesis in mice. Mechanistically, the amino-terminal region of FUNDC2 interacts with the GTPase domain of mitofusin 1 (MFN1), thus inhibits its activity in promoting fusion of outer mitochondrial membrane. As a result, loss of FUNDC2 leads to mitochondrial elongation, decreased mitochondrial respiration, and reprogrammed cellular metabolism. These results identified a mechanism of mitochondrial fragmentation in cancer through MFN1 inhibition by FUNDC2, and suggested FUNDC2 as a potential therapeutic target of HCC.
ZFP281-BRCA2 prevents R-loop accumulation during DNA replication
Authors: Wang Yan , Ma Binbin , Liu Xiaoxu , Gao Ge , Che Zhuanzhuan , Fan Menghan , Meng Siyan , Zhao Xiru , Sugimura Rio , Cao Hua , Zhou Zhongjun , Xie Jing , Lin Chengqi , Luo Zhuojuan 
Published: June 2022

AbstractR-loops are prevalent in mammalian genomes and involved in many fundamental cellular processes. Depletion of BRCA2 leads to aberrant R-loop accumulation, contributing to genome instability. Here, we show that ZFP281 cooperates with BRCA2 in preventing R-loop accumulation to facilitate DNA replication in embryonic stem cells. ZFP281 depletion reduces PCNA levels on chromatin and impairs DNA replication. Mechanistically, we demonstrate that ZFP281 can interact with BRCA2, and that BRCA2 is enriched at G/C-rich promoters and requires both ZFP281 and PRC2 for its proper recruitment to the bivalent chromatin at the genome-wide scale. Furthermore, depletion of ZFP281 or BRCA2 leads to accumulation of R-loops over the bivalent regions, and compromises activation of the developmental genes by retinoic acid during stem cell differentiation. In summary, our results reveal that ZFP281 recruits BRCA2 to the bivalent chromatin regions to ensure proper progression of DNA replication through preventing persistent R-loops.
Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial
Authors: Strauss Kevin A. , Farrar Michelle A. , Muntoni Francesco , Saito Kayoko , Mendell Jerry R. , Servais Laurent , McMillan Hugh J. , Finkel Richard S. , Swoboda Kathryn J. , Kwon Jennifer M. , Zaidman Craig M. , Chiriboga Claudia A. , Iannaccone Susan T. , Krueger Jena M. , Parsons Julie A. , Shieh Perry B. , Kavanagh Sarah , Tauscher-Wisniewski Sitra , McGill Bryan E. , Macek Thomas A. 
Published: June 2022

AbstractSPR1NT (NCT03505099) was a Phase III, multicenter, single-arm study to investigate the efficacy and safety of onasemnogene abeparvovec for presymptomatic children with biallelicSMN1mutations treated at ≤6 weeks of life. Here, we report final results for 14 children with two copies ofSMN2, expected to develop spinal muscular atrophy (SMA) type 1. Efficacy was compared with a matched Pediatric Neuromuscular Clinical Research natural-history cohort (n = 23). All 14 enrolled infants sat independently for ≥30 seconds at any visit ≤18 months (Bayley-III item #26;P < 0.001; 11 within the normal developmental window). All survived without permanent ventilation at 14 months as per protocol; 13 maintained body weight (≥3rd WHO percentile) through 18 months. No child used nutritional or respiratory support. No serious adverse events were considered related to treatment by the investigator. Onasemnogene abeparvovec was effective and well-tolerated for children expected to develop SMA type 1, highlighting the urgency for universal newborn screening.
Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial
Authors: Strauss Kevin A. , Farrar Michelle A. , Muntoni Francesco , Saito Kayoko , Mendell Jerry R. , Servais Laurent , McMillan Hugh J. , Finkel Richard S. , Swoboda Kathryn J. , Kwon Jennifer M. , Zaidman Craig M. , Chiriboga Claudia A. , Iannaccone Susan T. , Krueger Jena M. , Parsons Julie A. , Shieh Perry B. , Kavanagh Sarah , Wigderson Melissa , Tauscher-Wisniewski Sitra , McGill Bryan E. , Macek Thomas A. 
Published: June 2022

AbstractMost children with biallelicSMN1deletions and threeSMN2copies develop spinal muscular atrophy (SMA) type 2. SPR1NT (NCT03505099), a Phase III, multicenter, single-arm trial, investigated the efficacy and safety of onasemnogene abeparvovec for presymptomatic children with biallelicSMN1mutations treated within six postnatal weeks. Of 15 children with threeSMN2copies treated before symptom onset, all stood independently before 24 months (P < 0.0001; 14 within normal developmental window), and 14 walked independently (P < 0.0001; 11 within normal developmental window). All survived without permanent ventilation at 14 months; ten (67%) maintained body weight (≥3rd WHO percentile) without feeding support through 24 months; and none required nutritional or respiratory support. No serious adverse events were considered treatment-related by the investigator. Onasemnogene abeparvovec was effective and well-tolerated for presymptomatic infants at risk of SMA type 2, underscoring the urgency of early identification and intervention.
Perovskite- and Dye-Sensitized Solar-Cell Device Databases Auto-generated Using ChemDataExtractor
Authors: Beard Edward J. , Cole Jacqueline M. 
Published: June 2022

AbstractThe number of scientific publications reporting cutting-edge third-generation photovoltaic devices is increasing rapidly, owing to the pressing need to develop renewable-energy technologies that address the climate-change crisis. Consequently, the field could benefit from a central repository where photovoltaic-performance metrics, such as the power-conversion efficiency (η) are recorded. We present two automatically generated databases that contain photovoltaic properties and device material data for dye-sensitized solar cells (DSCs) and perovskite solar cells (PSCs), totalling 660,881 data entries representing 57,678 photovoltaic devices. The databases were generated by applying the text-mining toolkit ChemDataExtractor on a corpus of 25,720 articles. A multi-faceted evaluation, incorporating manual and automatic methods, was applied to ensure that the data contained therein were of the highest quality, with precision metrics ranging from 73.1% to 95.8%. The DSC database contains 475,045 entries representing 41,680 devices, and the PSC database contains 185,836 entries representing 15,818 devices. The databases are available in MongoDB and JSON formats, which can be queried in Python, R, Java and MATLAB for data-driven photovoltaic materials discovery.
Histone deacetylase 2 inhibitor valproic acid attenuates bisphenol A-induced liver pathology in male mice
Authors: Al-Griw Mohamed A. , Alshibani Zaynab Osama , Alghazeer Rabia , Elhensheri Mohamed , Tabagh Refaat. M. , Eskandrani Areej A. , Alansari Wafa S. , Habibulla Mahmoud M. , Shamlan Ghalia 
Published: June 2022

AbstractAccumulating evidence indicates the role of endocrine disruptor bisphenol A (BPA) in many pathological conditions. Histone deacetylase (HDAC) inhibition has potential for the treatment of many diseases/abnormalities. Using a mouse BPA exposure model, this study investigated the hepatoprotective effects of the Food and Drug Administration–approved HDAC2 inhibitor valproic acid (VPA) against BPA-induced liver pathology. We randomly divided 30 adult male Swiss albino mice (8 weeks old; N = 6) into five groups: group 1, no treatment (sham control (SC)); group 2, only oral sterile corn oil (vehicle control (VC)); group 3, 4 mg/kg/day of oral BPA (single dose (BPA group)); group 4, 0.4% oral VPA (VPA group); and group 5, oral BPA + VPA (BPA + VPA group). At the age of 10 weeks, the mice were euthanized for biochemical and histological examinations. BPA promoted a significant decrease in the body weight (BW), an increase in the liver weight, and a significant increase in the levels of liver damage markers aspartate aminotransferase and alanine aminotransferase in the BPA group compared to SC, as well as pathological changes in liver tissue. We also found an increase in the rate of apoptosis among hepatocytes. In addition, BPA significantly increased the levels of oxidative stress indices, malondialdehyde, and protein carbonylation but decreased the levels of reduced glutathione (GSH) in the BPA group compared to SC. In contrast, treatment with the HDAC2 inhibitor VPA significantly attenuated liver pathology, oxidative stress, and apoptosis and also enhanced GSH levels in VPA group and BPA + VPA group. The HDAC2 inhibitor VPA protects mice against BPA-induced liver pathology, likely by inhibiting oxidative stress and enhancing the levels of antioxidant-reduced GSH.
Extra-neural signals from severed nerves enable intrinsic hand movements in transhumeral amputations
Authors: Ahkami Bahareh , Mastinu Enzo , Earley Eric J. , Ortiz-Catalan Max 
Published: June 2022

AbstractRobotic prostheses controlled by myoelectric signals can restore limited but important hand function in individuals with upper limb amputation. The lack of individual finger control highlights the yet insurmountable gap to fully replacing a biological hand. Implanted electrodes around severed nerves have been used to elicit sensations perceived as arising from the missing limb, but using such extra-neural electrodes to record motor signals that allow for the decoding of phantom movements has remained elusive. Here, we showed the feasibility of using signals from non-penetrating neural electrodes to decode intrinsic hand and finger movements in individuals with above-elbow amputations. We found that information recorded with extra-neural electrodes alone was enough to decode phantom hand and individual finger movements, and as expected, the addition of myoelectric signals reduced classification errors both in offline and in real-time decoding.
Influences of social uncertainty and serotonin on gambling decisions
Authors: Bellucci Gabriele , Münte Thomas F. , Park Soyoung Q. 
Published: June 2022

AbstractIn many instances in life, our decisions’ outcomes hinge on someone else’s choices (i.e., under social uncertainty). Behavioral and pharmacological work has previously focused on different types of uncertainty, such as risk and ambiguity, but not so much on risk behaviors under social uncertainty. Here, in two different studies using a double-blind, placebo-controlled, within-subject design, we administrated citalopram (a selective-serotonin-reuptake inhibitor) to male participants and investigated decisions in a gambling task under social and nonsocial uncertainty. In the social condition, gamble outcomes were determined by another participant. In the nonsocial condition, gamble outcomes were determined by a coin toss. We observed increased gamble acceptance under social uncertainty, especially for gambles with lower gains and higher losses, which might be indicative of a positivity bias in social expectations in conditions of high uncertainty about others’ behaviors. A similar effect was found for citalopram, which increased overall acceptance behavior for gambles irrespective of the source of uncertainty (social/nonsocial). These results provide insights into the cognitive and neurochemical processes underlying decisions under social uncertainty, with implications for research in risk-taking behaviors in healthy and clinical populations.
Statistical determinants of visuomotor adaptation along different dimensions during naturalistic 3D reaches
Authors: Ferrea E. , Franke J. , Morel P. , Gail A. 
Published: June 2022

AbstractNeurorehabilitation in patients suffering from motor deficits relies on relearning or re-adapting motor skills. Yet our understanding of motor learning is based mostly on results from one or two-dimensional experimental paradigms with highly confined movements. Since everyday movements are conducted in three-dimensional space, it is important to further our understanding about the effect that gravitational forces or perceptual anisotropy might or might not have on motor learning along all different dimensions relative to the body. Here we test how well existing concepts of motor learning generalize to movements in 3D. We ask how a subject’s variability in movement planning and sensory perception influences motor adaptation along three different body axes. To extract variability and relate it to adaptation rate, we employed a novel hierarchical two-state space model using Bayesian modeling via Hamiltonian Monte Carlo procedures. Our results show that differences in adaptation rate occur between the coronal, sagittal and horizontal planes and can be explained by the Kalman gain, i.e., a statistically optimal solution integrating planning and sensory information weighted by the inverse of their variability. This indicates that optimal integration theory for error correction holds for 3D movements and explains adaptation rate variation between movements in different planes.
Comparison of three validated systems to analyse spinal shape and motion
Authors: Dreischarf Bettina , Koch Esther , Dreischarf Marcel , Schmidt Hendrik , Pumberger Matthias , Becker Luis 
Published: June 2022

AbstractThe assessment of spinal shape and mobility is of great importance for long-term therapy evaluation. As frequent radiation should be avoided, especially in children, non-invasive measurements have gained increasing importance. Their comparability between each other however stays elusive. Three non-invasive measurement tools have been compared to each other: Idiag M360, raster stereography and Epionics SPINE. 30 volunteers (15 females/15 males) have each been assessed by each system, investigating lumbar lordosis, thoracic kyphosis and spinal range-of-motion in the sagittal plane. Lumbar lordosis differed significantly (p < 0.001) between measurement devices but correlated significant to each other (Pearson’s r 0.5–0.6). Regarding thoracic kyphosis no significant difference and a high correlation (r = 0.8) could be shown between Idiag M360 and raster stereography. For lumbar mobility resulting measurements differed significantly and correlated only moderate between Idiag M360 and Epionics SPINE. Although the different measurement systems are moderate to high correlated to each other, their absolute agreement is limited. This might be explained by differences in their angle definition for lordotic and kyphotic angle, their measurement placement, or their capturing of mobility (static vs. dynamic assessment). Therefore, for long-term evaluation of the back profile, inter-modal comparison of values between different non-invasive devices should be avoided.
Image resampling and discretization effect on the estimate of myocardial radiomic features from T1 and T2 mapping in hypertrophic cardiomyopathy
Authors: Marfisi Daniela , Tessa Carlo , Marzi Chiara , Del Meglio Jacopo , Linsalata Stefania , Borgheresi Rita , Lilli Alessio , Lazzarini Riccardo , Salvatori Luca , Vignali Claudio , Barucci Andrea , Mascalchi Mario , Casolo Giancarlo , Diciotti Stefano , Traino Antonio Claudio , Giannelli Marco 
Published: June 2022

AbstractRadiomics is emerging as a promising and useful tool in cardiac magnetic resonance (CMR) imaging applications. Accordingly, the purpose of this study was to investigate, for the first time, the effect of image resampling/discretization and filtering on radiomic features estimation from quantitative CMR T1 and T2 mapping. Specifically, T1 and T2 maps of 26 patients with hypertrophic cardiomyopathy (HCM) were used to estimate 98 radiomic features for 7 different resampling voxel sizes (at fixed bin width), 9 different bin widths (at fixed resampling voxel size), and 7 different spatial filters (at fixed resampling voxel size/bin width). While we found a remarkable dependence of myocardial radiomic features from T1 and T2 mapping on image filters, many radiomic features showed a limited sensitivity to resampling voxel size/bin width, in terms of intraclass correlation coefficient (> 0.75) and coefficient of variation (< 30%). The estimate of most textural radiomic features showed a linear significant (p < 0.05) correlation with resampling voxel size/bin width. Overall, radiomic features from T2 maps have proven to be less sensitive to image preprocessing than those from T1 maps, especially when varying bin width. Our results might corroborate the potential of radiomics from T1/T2 mapping in HCM and hopefully in other myocardial diseases.
Neuroergonomic assessment of developmental coordination disorder
Authors: Joshi Shawn , Weedon Benjamin D. , Esser Patrick , Liu Yan-Ci , Springett Daniella N. , Meaney Andy , Inacio Mario , Delextrat Anne , Kemp Steve , Ward Tomás , Izadi Hooshang , Dawes Helen , Ayaz Hasan 
Published: June 2022

AbstractUntil recently, neural assessments of gross motor coordination could not reliably handle active tasks, particularly in realistic environments, and offered a narrow understanding of motor-cognition. By applying a comprehensive neuroergonomic approach using optical mobile neuroimaging, we probed the neural correlates of motor functioning in young people with Developmental Coordination Disorder (DCD), a motor-learning deficit affecting 5–6% of children with lifelong complications. Neural recordings using fNIRS were collected during active ambulatory behavioral task execution from 37 Typically Developed and 48 DCD Children who performed cognitive and physical tasks in both single and dual conditions. This is the first of its kind study targeting regions of prefrontal cortical dysfunction for identification of neuropathophysiology for DCD during realistic motor tasks and is one of the largest neuroimaging study (across all modalities) involving DCD. We demonstrated that DCD is a motor-cognitive disability, as gross motor /complex tasks revealed neuro-hemodynamic deficits and dysfunction within the right middle and superior frontal gyri of the prefrontal cortex through functional near infrared spectroscopy. Furthermore, by incorporating behavioral performance, decreased neural efficiency in these regions were revealed in children with DCD, specifically during motor tasks. Lastly, we provide a framework, evaluating disorder impact in ecologically valid contexts to identify when and for whom interventional approaches are most needed and open the door for precision therapies.