bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient volume forecasting in the radiology department using deep learning and statistical-based models
Authors: pala zeydin , Atıcı Ramazan , Yaldız Erkan 
Published: August 2022

Abstract
As the demand for medical care increases significantly every day, the issue of managing the volume of patients in hospitals and radiology units becomes more and more important. Due to the radiation emitted by the devices in the radiology unit, the minimum time spent by the patients for radiological imaging in hospitals is of vital importance both for the hospital and the patient. This study aims to estimate the monthly number of images in the hospital radiology unit using deep learning models and statistical-based models, so that it is prepared for the future in a more planned way. While deep learning models such as LSTM, MLP, NNAR and ELM were used for forecasting, statistics- based prediction models such as ARIMA, SES, TBATS, HOLT, and THETAF were also used. In order to evaluate the performance of the models, symmetric mean absolute percentage error (sMAPE), and mean absolute scaled error (MASE), which are very popular recently, were used. Results show that while the LSTM model performed better than the deep learning group in estimating the number of monthly radiological case images, the ARIMA model performed better in the statistical-based group. It is believed that the findings obtained will make important contributions to the future planning of the hospital by increasing both the service quality and patient satisfaction by facilitating the hospital managers in managing the volume of patients coming to the hospital and transferred to the radiology unit more efficiently.
Experimental analysis of earthquake prediction using machine learning classifiers, curve fitting, and neural modeling
Authors: Chittora Pankaj , Chakrabarti Tulika , Debnath Papiya , Gupta Amit , Chakrabarti Prasun , Praveen S Phani , Margala Martin , Elngar Ahmed A. 
Published: August 2022

Abstract
An earthquake is one of the most massive natural disasters which happens unexpectedly shaking the earth's surface. Due to earthquakes, not only infrastructure but also buildings get damaged thereby affecting lifestyle. For the early-stage prediction of the earthquake impact, machine learning can play a vital role, and this entails the novelty of the work. For this perception, six different machine learning classifiers namely Artificial Neural Network, Random Tree, CHAID, Discriminant, XGBoost Tree, and Tree-AS on six datasets of different regions of India. All the algorithms have been applied to each dataset. The objective of the research is to predict the value of magnitude for the future earthquake in India and nearby regions from the historical data on earthquakes. From the result, It has been observed that for Andaman & Nikobar dataset XGBoost Tree achieved the highest accuracy with 99.10%, for the Gujarat dataset Tree-AS achieved the highest accuracy with 91.67%, for the North India dataset Artificial Neural Network achieved the highest accuracy with 99.13%, for North East India dataset XGBoost Tree achieved the highest accuracy with 99.04%, for Nepal-UP-Bihar dataset XGBoost Tree achieved the highest accuracy with 99.01%, for Nearby India’s Country dataset XGBoost Tree achieved the highest accuracy with 92.12%. From all the results, it has been noted that XGBoost tree classifier performed well in most datasets., the Curve has been made between magnitude & gap, magnitude & magnitude error, and magnitude and depth error for finding the mathematical relation between them.
Foliar transcriptomes reveal candidate genes for late blight resistance in cultivars of diploid potato Solanum goniocalyx
Authors: Cruz Germán De la , Blas Raúl , Pérez Willmer , Neyra Edgar , Ortiz Rodomiro 
Published: August 2022

Abstract
Characterization of major resistance (R) genes to late blight (LB) –caused by the oomycete Phytophthora infestans– is very important for potato breeding. The objective of this study was to identify novel genes for resistance to LB from cultivated diploid Solanum goniocalyx. Using comparative analysis with a bio-conductor package for differential expression analysis of transcriptomes of two S. goniocalyx accessions with contrasting levels of resistance to LB were analyzed digital gene expression data (edgeR). As a result, various differentially expressed genes (P ≤ 0.0001, Log2FC ≥ 2, FDR < 0.001) were noted. The combination of transcriptomic analysis provided a reasonable number of candidate genes that are overexpressed and under expressed, thereby giving to S. goniocalyx high resistance to LB. The functional analysis of R genes and their corresponding proteins related to disease resistance, NBS-LRR domain proteins and specific disease resistance proteins. Comparative analysis of specific tissue transcriptomes in resistant and susceptible genotypes can be used for identifying rapidly candidate R genes, thus adding novel genes from S. goniocalyx for host plant resistance to P. infestans in potato.
Repair of ruptured sinus of Valsalva aneurysm with a heart shape to the pericardium cavity in a 54-year-old patient
Authors: Nakajima Tomohiro , Iba Yutaka , Shibata Tsuyoshi , Hosaka Itaru , Nakazawa Jyunji , Kawaharada Nobuyoshi 
Published: August 2022

Abstract
We herein describe a 58-year-old man with type A aortic dissection due to stent graft-induced new entry (SINE). Six years previously, he had developed severe back pain and was diagnosed with type B aortic dissection after computed tomography examination. Because the primary entry was positioned at the descending aorta, we conducted thoracic endovascular aortic repair for exclusion of the entry with a GORE TAG conformable thoracic aortic. He was thereafter followed by our hospital. Six years later, he developed jaw pain and was examined at another hospital. He was transferred to our hospital because of the possibility of type A dissection. Computed tomography revealed type A aortic dissection with proximal site SINE. Emergency partial arch replacement was conducted, and he was discharged on postoperative day 27. Because the entry was at the lesser curve of the arch, we excluded the entry and conducted partial arch replacement.
The spectrum of cardiovascular complications related to immune-checkpoint inhibitor treatment
Authors: Andres Maria Sol , Ramalingam Sivatharshini , Rosen Stuart D. , Baksi John , Khattar Rajdeep , Kirichenko Yulia , Young Kate , Yousaf Nadia , Okines Alicia , Huddart Robert , Harrington Kevin , Furness Andrew , Turajlic Samra , Pickering Lisa , Popat Sanjay , Larkin James , Lyon Alexander R. 
Published: August 2022

Abstract
Background: The full range of cardiovascular complications related to the use of Immune checkpoint inhibitors (ICI) is not fully understood. We aim to describe the spectrum of cardiovascular adverse events (cvAEs) by presenting our real-world experience of the diagnosis and management of these complications. Methods: Two thousand six hundred and forty-seven (2647) patients were started on ICI treatment between 2014 and 2020. Data from 110 patients referred to the cardio-oncology service with a suspected cvAE was collected prospectively and analysed. Results: Eighty-nine patients (3.4%) were confirmed to have cvAEs while on ICI therapy. Myocarditis was the most frequent event (33/89), followed by tachyarrhythmia (27/89), non-inflammatory left ventricular dysfunction (NILVD) (15/89) and pericarditis (7/89). Results from myocarditis and non-inflammatory left ventricular dysfunction cohorts were compared. Myocarditis and NILVD showed significant differences in respect of troponin elevation, cardiac magnetic resonance abnormalities and ventricular function. Dual ICI therapy and other immune related adverse events were more frequently associated with myocarditis than NILVD. There was a significant difference in the median time from starting ICI treatment to presentation with myocarditis versus NILVD (12 vs 26 weeks p = 0.049). Through early recognition of myocarditis, prompt treatment with steroids and interruption of ICI, there were no cardiovascular in-hospital deaths. NILVD did not require steroid treatment and ICI could be restarted safely.Conclusions: The full spectrum of cardiovascular complication in patients with immune checkpoint inhibitors is much broader than initially described. Myocarditis remains the most frequent cvAE related to ICI treatment. Atrial tachyarrhythmias and NILVD were also frequent in this cohort. NILVD has a different presentation from ICI-related myocarditis, usually presenting after 6 months of treatment commencement and presents no inflammatory features.
Application of local defect internal resonance method for detection of adhesive interface debonding
Authors: Li Zhihang , Xiao Li , Qu Wenzhong 
Published: August 2022

Abstract
The bonding interface is prone to debonding under environmental implication and long-time operational vibrations, which may affect the structural integrity severely. This paper presents an interface debonding identification method to solve adhesive interface debonding between aluminum plates in the framework of the internal resonance of local defects. Firstly, based on a two degree of freedom (2-DOF) nonlinear model of local defects in the bonding interface, the multi-scale method is used to explain the mechanism of the internal resonance of local defects and conditions for the generation of the internal resonance. By analyzing the saturation phenomenon peculiar to the 2:1 internal resonance of local defects in the spectrum, the adhesive interface debonding identification experiment of a bonding aluminum plate is carried out. The effectiveness of the local defect internal resonance method is verified by experimental results and theoretical analysis. The results demonstrate that the bonding structure appears the saturation phenomenon under the specific excitation conditions. Furtherly the local defect internal resonance method is found to be effective in solving adhesive interface debonding detection.
Sleep Quality in Patients with Psoriatic Arthritis and Its Relationship with Disease Activity and Comorbidities: a Cross- Sectional Study
Authors: Toledano Esther , Hidalgo Cristina , Gómez-Lechón Luis , Ibáñez Marta , Chacón Carolina Cristina , Pastor Sonia , Montilla Carlos 
Published: August 2022

Abstract
Background. The assessment of psoriatic arthritis is complex and multidimensional. It is increasingly common to include the patient perspective using patient-reported outcomes. Although some research has explored sleep quality in patients with psoriatic arthritis, most studies have had small sample sizes, failed to assess sleep quality considering the inflammatory process together with the psychological well-being of patients, and have not clearly described any use of sleep medication. Further, research to date has not provided data on the relationship of sleep quality with axial forms. In this context, the objective of this study was to assess sleep quality in patients with psoriatic arthritis and its relationship with clinical characteristics, disease activity, functioning, disease impact, fatigue and psychological status.Methods. A cross-sectional study was conducted including 247 consecutive patients with PsA recruited during 2021. Sleep quality was measured using the Pittsburgh Sleep Quality Index. We assessed correlations of Pittsburgh Sleep Quality Index score with peripheral disease activity (Clinical Disease Activity Index for PSoriatic Arthritis), axial disease activity (Ankylosing Spondylitis Disease Activity Score-C-reactive protein and Bath Ankylosing Spondylitis Disease Activity Index), functioning (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire), impact (Psoriatic Arthritis Impact of Disease questionnaire), anxiety, depression (Hospital Anxiety and Depression Scale) and fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue) scores. A logistic regression model was built establishing two groups of patients stratified by Pittsburgh Sleep Quality Index (≥6 indicating poor sleep quality).Results. Nearly two-thirds (63.15%) of patients had poor sleep quality. Poorer sleep quality was associated with being female, higher joint counts, greater peripheral and axial disease activity, fatigue, anxiety and depression, functioning and disease impact (p<0.001). Multiple linear regression analysis found that pain (β:0.48; p<0.001) and fatigue (β: -0.13; p<0.001) contributed 43% to the sleep quality model. In logistic regression analysis, pain (OR: 1.20 [1.01-1.43), fatigue (OR: 0.89 [0.84, 0.95]) and anxiety (OR: 1.27 [1.06-1.51]) explained 48% of poor sleep quality. Conclusions. Poor sleep quality was common among patients with psoriatic arthritis. Emotional factors (fatigue, anxiety) seemed more important than inflammatory factors in sleep quality.
Severe Combined Immunodeficiency: Improved survival leading to detection of underlying liver disease
Authors: Vittal Anusha , Majeed Nehna Abdul , Garabedian Elizabeth , Marko Jamie , Kleiner David E , Sokolic Rob , Candotti Fabio , Malech Harry , Heller Theo , Koh Christopher 
Published: August 2022

Abstract
Background
Adenosine deaminase deficiency (ADA) is a primary autosomal recessive genetic disorder leading to severe combined immunodeficiency (SCID). It is characterized pathophysiologically by intracellular accumulation of toxic products affecting lymphocytes and other organ systems. This cross sectional study was conducted to describe the liver disease in a cohort of patients with autosomal recessive ADA-SCID.
Methods
A single center cross sectional retrospective analysis (2006 to 2019) was performed in 18 patients with genetically confirmed ADA-SCID. Liver disease was defined as ≥1.5x the gender specific upper limit of normal (ULN; 33 IU/L for males and 25 IU/L for females) or moderate and severe increase in liver echogenicity on ultrasound.
Results
The cohort included 11 males, the median age was 11.5 (3.5–30.0 years) and median BMI was 18.4 kg/m2. Eighteen (100%), Seven (38%) and five (27%) patients had enzyme replacement therapy (ERT), gene therapy (GT) and hematopoietic stem cell transplant (HSCT). Five (?%) patients had ALT levels more than 1.5x the ULN. Liver echogenicity was increased mildly in 6 (33%), moderately in 2 (11%), severely in 2 (11%) and normal in 8 (44.4%) patients. All patients had normal FIB-4 and NAFLD fibrosis score indicating absence of advanced fibrosis in our cohort. Of 8 patients who had liver biopsies for diagnostic purposes, steatohepatitis measured by histopathology NASH-CRN scoring was noted in 4 patients.
Discussion
Non-immunologic manifestations of ADA-SCID have become more apparent in recent years as survival improved. In our cohort, the most common liver disease manifestation was steatosis. We postulate that hepatic steatosis noted is possibly multifactorial - recurrent infection, exposure to multiple medications and increased BMI.
Prevalence of Y chromosomal microdeletion in Indian infertile males with sperm abnormality
Authors: S Archana , J Vijayalakshmi , G Usha Rani , Paul Solomon F.D. , Manjula G. , Reddy Sanjeeva 
Published: August 2022

Abstract
During gamete’s development and spermatogenesis, certain genes on the Y chromosome (Yq) in Male specific region (MSR) are responsible for human gametes formation. The long arm Yq is composed of both euchromatin and the genetically inactive heterochromatin regions. This region contains the Azoospermia factors AZFa, AZFb and AZFc. In the case of male infertility, microdeletions on the Yq chromosome appear to be structural chromosomal anomalies linked to sperm abnormality. The present study was aimed to look at the incidence, of Asthenospermia (AS), Teratospermia (TS), Oligospermia (OS) and Oligoasthoteratospermia (OAT) patterns of Y chromosomal microdeletions in Indian infertile men with a (AZF a, b, c). In this study, 75 infertile men as case and 75 fertile men as a control were examined for AZF locus microdeletion utilizing sequence-tagged sites. The AZFc region of germ cell DNA (50.6%) being the most deleted section in infertile men when compared to blood DNA (21.3%), followed by deletions in the AZFb region (21.3%) in germ cell DNA whereas blood DNA had a and no microdeletion in the AZFa region in both germ cell DNA and blood DNA. infertile men had that significant Yq microdeletion in both AZF b and also AZFc. Around 33% (25) of 75 infertile men had AZF (a, b, c) region microdeletion in blood DNA, compared to it germ cell DNA had a larger percentage of 72%(54) of Y chromosome micro deletions in the study samples, high frequency rate of microdeletions seen in germ cell DNA. PCR-based Y chromosome microdeletions screening using germ cell DNA along with Genomic DNA might help in screening genetic abnormality of infertile men those who endure assisted reproductive technology treatments. This might be attributable to the interplay of lifestyle factors and genetic factors both contribute to the risk of developing these germ line deletions.
Assessing the Cost-Effectiveness of waiting list reduction strategies for a breast radiology department: a real-life case study
Authors: Fanizzi Annarita , Graps Elisabetta , Bavaro Domenica Antonia , Farella Marco , Bove Samantha , Campobasso Francesco , Comes Maria Colomba , Cristofaro Cristian , Forgia Daniele La , Milella Martina , Iacovelli Serena , Villani Rossella , Signorile Rahel , De Bartolo Alessio , Lorusso Vito , Massafra Raffaella 
Published: August 2022

Abstract
A timely diagnosis is essential for improving breast cancer patients’ survival and designing targeted therapeutic plans. For this purpose, the screening timing, as well as the related waiting lists, are decisive. Nonetheless, even in economically advanced countries, breast cancer radiology centres fail in providing effective screening programs. Actually, a careful hospital governance should encourage waiting lists reduction programs, not only for improving patients care, but also for minimizing costs associated with the treatment of advanced cancers. Thus, in this work, we proposed a model to evaluate several scenarios for an optimal distribution of the resources invested in a Department of Breast Radiodiagnosis. Particularly, we performed a cost-benefit analysis as a technology assessment method to estimate both costs and health effects of the screening program, to maximise both benefits related to the quality of care and resources employed by the Department of Breast Radiodiagnosis of Istituto Tumori “Giovanni Paolo II” of Bari in 2019. Specifically, we determined the Quality-Adjusted Life Year (QALY) for estimating health outcomes, in terms of usefulness of two hypothetical screening strategies with respect to the current one. While the first hypothetical strategy adds one team made up of a doctor, a technician and a nurse, along with an ultrasound and a mammograph, the second one adds two afternoon teams. This study showed that the most cost-effective incremental ratio could be achieved by reducing current waiting lists from 32 to 16 months. Finally, our analysis revealed that this strategy would also allow to include more people in the screening programs (60,000 patients in 3 years).
The Efficacy and Safety for Single Dose of Rituximab in Children with Steroid Dependent- Minimal Change Nephrotic Syndrome by Two Years
Authors: Niu Xiao-Ling , Gu Yun-Fan , Feng Dan , Hao Sheng , Kuang Xin-Yu , Wang Ping , Huang Wen-Yan 
Published: August 2022

Abstract
Purpose: Exploring efficacy and safety for first single dose of rituximab(RTX) in children with steroid dependent-minimal change nephrotic syndrome(SD-MCNS) by retrospective analysis in two years after RTX and established the model of prediction for relapsing. Methods: Children with SD-MCNS, admitted in our hospital and received single dose of RTX(375mg/m2) by first time from Oct 2011 to Dec 2018, were included. They were followed by 24 months. The clinical and laboratory data before and after RTX were collected and analyzed. Results: 77 patients (M/F: 51/26) were included. The median age was 8.17 years old. The median dependent dosage of steroids was 7.87mg/m2·d. The efficacy for the first single dose of RTX in children with SD-MCNS was 90.91%(70/77), 60 patients (77.9%) for complete remission and 10(13.0%) for partial remission. The relapse rate was 78.3%. There were no severe side effects. Age using RTX, dependent dosage of steroids and CD4+ level before RTX had relationship with efficacy of RTX (B=0.390, -0.091, 0.134, P<0.05). Sex, ageing using RTX, IgE before RTX, WBC and CD3+ when stopping steroids were related to relapsing (B=-1.485, -0.373, 1.278, -0.417, 0.135, P<0.05). The model of prediction for relapsing after RTX in children with SD-MCNS was established.Conclusion: Single dose of RTX is efficiency and safe in children with SD-MCNS, but with high recurrence rate. Patients with older age using RTX, or smaller dependent-dosage of steroids, or higher CD4+ have better efficacy for RTX. Male younger patients with higher IgE relapse more easily.
Idiopathic central diabetes insipidus in a large cohort of patients; The hypopituitarism ENEA rare observational (HEROS) study
Authors: Iraqi Hiba Masri , Shimon Ilan , Pigarova Ekaterina , Colao Annamaria , Baraf Lior , Tsoli Marina , Doknic Mirjana , Bitti Silvia Ricci , Giordano Roberta , Barbot Mattia , Akirov Amit , Witek Przemyslaw , Serebro Merav , Auer Matthias , Tóth Miklós 
Published: August 2022

Abstract
Central Diabetes Insipidus (CDI) is mainly associated with structural pathologies of the hypothalamic-pituitary area. Etiologies underlying CDI are identified in most patients, however idiopathic CDI is reported in 13-17% of cases after excluding other etiologies. The Hypopituitarism ENEA Rare Observational Study (HEROS study) retrospectively collected data of patients with idiopathic CDI from 14 pituitary centers in 9 countries.The cohort included 92 patients (59 females), mean age at diagnosis was 35.4±20.7 years, and a mean follow up of 18.2±14.5 years following CDI diagnosis. In 6 women, diagnosis was related to pregnancy. Of 83 patients with available data on pituitary imaging, 40 had normal sellar imaging, and 43 had pathology of the posterior pituitary or the stalk, including loss of the bright spot, posterior pituitary atrophy or stalk enlargement. Anterior pituitary hormone deficiencies at presentation included hypogonadism in 6 patients (5 females), and hypocortisolism in one; during follow-up new anterior pituitary deficiencies developed in 6 patients. Replacement treatment with desmopressin was given to all patients except one, usually with an oral preparation. During follow up, no underlying disease causing CDI was identified in any patient.Conclusions: patients with idiopathic CDI following investigation at baseline are stable with no specific etiology depicted during long-term follow-up.