bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostics of pulmonary sarcoidosis by the method of computed tomographic densitovolumetry
Authors: Ignat’eva E. A. , Il’in A. V. , Perelman J. M. 
Published: July 2022

Aim. To develop a new method for quantitative evaluation of digital data of chest CT images of patients with sarcoidosis, to evaluate the diagnostic significance of the obtained quantitative indicators in comparison with functional pulmonary tests.Materials and methods. Healthy individuals (n=21) and patients with pulmonary sarcoidosis (n=101), divided into 5 groups according to J.G.Scadding classification, were examined. The lung function was assessed according to the data of spirometry, body plethysmography and the study of the lung diffusion capacity. All examined patients underwent a two-stage computed tomography of the lungs in the inspiratory and expiratory phases with the measurement in 3 density ranges.Results. The values of the obtained quantitative indicators, determined by the new method of CT-densitovolumetry, differed from the control group both in the general group of patients with sarcoidosis and in individual groups according to the J.G.Scadding classification. Correlations were found between radiometric measurements and lung function parameters. In patients with sarcoidosis, a larger volume of poorly ventilated sections was determined in comparison with the healthy group.Conclusion. The new method of CT-densitovolumetry makes it possible to quantify the entire volume of lung tissue in the area of tomographic coverage, the obtained results can be used as a useful tool in predicting the course of the disease and the response to ongoing therapy.
Analysis of indicators of endogenous intoxication in patients with communityacquired pneumonia associated with COVID-19
Authors: Кucher A. V. , Khodus S. V. , Prikhodko O. B. 
Published: July 2022

Aim. To assess the prognostic significance of hematological parameters of endogenous intoxication syndrome at the stage of routing patients with pneumonia associated with COVID-19.Materials and methods. 146 case histories of patients were analyzed, divided into 2 groups: patients who were referred for treatment to intensive care units based on the results of routing in the admission and diagnostic department (ADD) and patients referred for treatment to pulmonology departments. Upon admission of patients to the hospital, according to the case histories at the stage of ADD, an assessment of the clinical blood test was made, the calculation of hematological indicators of intoxication. Based on the data obtained, a ROC analysis was performed to determine the prognostic significance of hematological indicators of intoxication.Results. In patients who were in intensive care units, at the stage of sorting in the ADD, the concentration of leukocytes and the percentage of neutrophils were higher by 25.9 and 16.2%, respectively, in comparison with patients referred for treatment to the pulmonology departments, however, the percentage of lymphocytes and the quantitative concentration of erythrocytes was lower by 26.6 and 8.3%, respectively. The integral indicator of intoxication in patients in intensive care was higher by 38.6%, the leukocyte index of intoxication by 74.3% and the index of the ratio of neutrophils to lymphocytes by 81.5%. In patients of the same group, the index of the ratio of neutrophils to monocytes was lower by 28.7%, the index of the ratio of lymphocytes to monocytes by 44.9%. The sensitivity of the integral indicator of intoxication was 73.3%, the specificity was 51.2%; in the leukocyte index of intoxication – 57.3 and 51.2%, respectively; the sensitivity of the index of the ratio of neutrophils to monocytes was 57.3%, the specificity was 59.1%; the same figures for the index of the ratio of neutrophils to lymphocytes were 68 and 60%, respectively.Conclusion. It can be concluded that there is a rather high clinical prognostic value in the routing of patients with community-acquired pneumonia caused by COVID- 19 at the stage of initial examination in the ADD, such hematological parameters of intoxication as the integral index of intoxication and the index of the ratio of neutrophils to lymphocytes. We believe that hematological indicators of intoxication can complement prognostic scales and be used as another criterion in determining the routing of patients in ADD.
DEVELOPMENT OF AN EXPERT SYSTEM FOR THE DIAGNOSIS OF ENDOCRINE DISEASES BASED ON NEURAL NETWORK MODELING
Authors: Новикова Екатерина Ивановна , Фурсова Елена Анатольевна , Рощупкин Дмитрий Юрьевич , Дворников Олег Игоревич 
Published: July 2022

Наиболее важным направлением в лечении больных с эндокринными заболеваниями, повышении уровня качества их жизни, снижении смертности и увеличении продолжительности жизни является выявление заболеваний на ранней стадии. Кроме того, выявление причин эндокринных заболеваний, таких как низкая выработка гормонов, полный или частичный недостаток инсулина в организме, недостаточное потребление йода, увеличение Т3 и Т4 гормонов в крови, воспаление тканей щитовидной железы, развивающиеся на фоне снижения иммунитета в процессе диагностики является важным и необходимым в целях выбора правильной тактики лечения. По данным на 2020 год численность пациентом с диагнозом «сахарный диабет» в Российской Федерации составляет около 3,5% (5,1 млн.). При этом численность пациентов с данным диагнозом выросла на 4,7% среди взрослых и на 5,3% среди детей, относительно 2019 года. Своевременная диагностика заболеваний, связанных с эндокринной системой, позволит выбрать верную тактику лечения, ускорить процессы постановки диагнозов и повысит их точность. В статье приведено описание экспертной системы для проведения диагностических мероприятий с точки зрения современных представлений о заболевания эндокринной системы с использованием достижений современной науки, таких как экспертные системы, поостренные на основе нейросетевого моделирования
The most important direction in the treatment of patients with endocrine diseases, improving their quality of life, reducing mortality and increasing life expectancy is the detection of diseases at an early stage. In addition, identifying the causes of endocrine diseases, such as low hormone production, complete or partial lack of insulin in the body, insufficient intake of iodine, an increase in T3 and T4 hormones in the blood, inflammation of the thyroid gland tissues that develop against a background of reduced immunity in the diagnostic process is important and essential for choosing the right treatment strategy. As of 2020, the number of patients diagnosed with diabetes mellitus in the Russian Federation is about 3.5% (5.1 million). At the same time, the number of patients with this diagnosis increased by 4.7% among adults and by 5.3% among children, compared to 2019. Timely diagnosis of diseases associated with the endocrine system will allow you to choose the right treatment tactics, speed up the process of making diagnoses and increase their accuracy. The article describes an expert system for carrying out diagnostic measures from the point of view of modern ideas about diseases of the endocrine system using the achievements of modern science, such as expert systems built on the basis of neural network modeling
MODELS FOR PROVIDING INFORMATION NON-INTERVENTION AND NON-DERIVABILITY IN MEDICAL INFORMATION SYSTEMS WITH SEMANTIC MODELS OF ACCESS CONTROL
Authors: Хвостов Виктор Анатольевич , Гулов Владимир Павлович , Чопоров Олег Николаевич , Проскурин Евгений Анатольевич 
Published: July 2022

На основе анализа применения теоретических основ решения проблемы скрытых каналов, предложенного Д. Денинг, и автоматного подхода анализа скрытых каналов к интерфейсу защищенных систем предложены модели обеспечения информационного невмешательства и невыводимости, ориентированные на применение в медицинских информационных системах (МИС) с семантическими моделями управления доступом. Автоматный подход к исследованию вопросов скрытых каналов, относящийся к интерфейсу защищенных информационных систем, разработанный на основе теории анализа проблемы скрытых каналов Д. Денинг, разработанный Дж. Гогеном, Дж. Мезигером, основан на вероятностном анализе широко используемых моделей управления доступом. В основе автоматных моделей информационного невмешательства лежат вероятностные процессы, протекающие в дискреционной (модели Харрисона, Рузо, Ульмана с расширением TAKE-GRANT) и полномочной моделях (Белла-ЛаПадулы). При использовании модели управления доступом предлагаемых для применения в МИС с мобильными станциями в качестве клиентов, основанной на онтологическом подходе с применением метрик семантической близости, автоматные модели информационного невмешательства Дж. Гогена, Дж. Мезигера применяться не могут. Статья посвящена анализу возможностей построения моделей обеспечения информационного невмешательства и невыводимости МИС с семантическими моделями управления доступом с мобильными станциями в качестве клиентов
Based on the analysis of the application of the theoretical foundations for solving the problem of covert channels proposed by D. Dening and the automaton approach of covert channel analysis to the interface of secure systems, models for ensuring information non-intervention focused on application in medical information systems (MIS) with semantic access control models are proposed. An automaton approach to the study of covert channels related to the interface of secure information systems, developed on the basis of the theory of analysis of the problem of covert channels by D. Dening, developed by J. Gauguin, J. Mesiger, is based on a probabilistic analysis of widely used access control models. At the heart of automatic models of informational non-intervention are probabilistic processes occurring in the discretionary (Harrison, Ruzo, Ullman models with the TAKE-GRANT extension) and empowered models (Bella-LaPadula). When using the access control model proposed for use in MIS with mobile stations as clients, based on an ontological approach using semantic proximity metrics, J. Gauguin's and J. Mesiger's automatic information non-intervention models cannot be used. The article is devoted to the analysis of the possibilities of building models for ensuring the information non-interference of MIS with semantic models of access control with mobile stations as clients
ANALYSIS OF ANEMIC SYNDROME IN COMORBID PATIENTS
Authors: Недомолкина Светлана Александровна , Зуйкова Анна Александровна , Великая Ольга Викторовна 
Published: July 2022

По данным Всемирной организации здравоохранения (ВОЗ) распространенность анемии в развитых странах составляет более 9%, а в развивающихся - более 43%. С возрастом частота встречаемости увеличивается, так как увеличивается и коморбидность. Около трети случаев анемического синдpома обусловлены анемией хронических заболеваний. Анемии хронических заболеваний (АХЗ) - актуальная проблема современной медицины, выделена из группы железодефицитных анемий и получила своё название в связи с воспалительным процессом, лежащим в её основе, поэтому АХЗ называют еще «анемией воспаления» или «цитокинопосредованной анемией». Анемия хронических заболеваний полиэтилогична и сопровождает инфекционные, опухолевые, ревматологические, сердечно-сосудистые, эндокринологические заболевания. Анемия является распространенной и зачастую несвоевременно диагностируемой коморбидной патологией многих хронических заболеваний, которая не только ухудшает качество жизни пациентов и снижает их толерантность к физическим нагрузкам, но также оказывает влияние на развитие хронических осложнений и сердечно-сосудистой патологии. В обзоре представлены основные патофизиологические механизмы связи анемии хронических заболеваний и коморбидной патологии, кратко приводятся результаты сравнительно недавних исследований в этой области, рассматривается их значение в клинической практике
According to the World Health Organization (WHO), the prevalence of anemia in developed countries is more than 9%, and in developing countries - more than 43%. With age, the frequency of occurrence increases, as comorbidity also increases. About a third of anemia syndrome cases are caused by anemia of chronic diseases. Anemia of chronic diseases (AHD) is an urgent problem of modern medicine, isolated from the group of iron deficiency anemia and got its name in connection with the inflammatory process underlying it, therefore AHD is also called "anemia of inflammation" or "cytokine-mediated anemia". Anemia of chronic diseases is polyethological and accompanies infectious, tumor, rheumatological, cardiovascular, endocrinological diseases. Anemia is a common and often untimely diagnosed comorbid pathology of many chronic diseases, which not only worsens the quality of patients life and reduces their tolerance to physical exertion, but also affects the development of chronic complications and cardiovascular pathology. The review presents the main pathophysiological mechanisms of the relationship between anemia of chronic diseases and comorbid pathology, summarizes the results of relatively recent studies in this area, and examines their significance in clinical practice
ANALISIS KARAKTERISTIK MUTU PALM KERNEL OIL (PKO) ASAL PT. PERKEBUNAN NUSANTARA IV UNIT USAHA PABATU
Authors: Paramitha Ayu , Ekawati Rina 
Published: July 2022

Palm Kernel Oil (PKO) merupakan minyak yang berasal dari kernel buah kelapa sawit. Minyak nabati yang dikonsumsi di Indonesia pada umumnya dalam bentuk produk hilir, seperti oleochemical sedangkan ekspor dalam bentuk minyak nabati. Salah satu hal yang dapat dilakukan pemerintah terkait hal tersebut adalah dengan memperbaiki mutu minyak PKO. Penelitian ini bertujuan untuk mengidentifikasi kesesuaian mutu PKO asal PT. Perkebunan Nusantara (PTPN) IV Unit Usaha Pabatu terhadap mutu PKO Standar Nasional Indonesia (SNI). Penelitian dilakukan selama 3 bulan (Oktober-Desember 2020) di Laboratorium Kimia Organik, Universitas Negeri Yogyakarta. Pemurnian minyak dilakukan melalui 3 tahapan yaitu degumming (metode acid degumming), bleaching (metode adsorbsi), dan deodorizing (metode vakum). Pengujian kadar ALB dilakukan dengan metode titrasi alkalimetri. Pengujian kadar air dan kadar kotoran dilakukan dengan metode gravimetri yaitu oven terbuka. Hasil penelitian menunjukkan bahwa kadar asam lemak bebas (ALB) PKO yaitu 3,08%, kadar air 2,77%, dan kadar kotoran 2,73%. Kadar ALB minyak PKO telah sesuai dengan SNI 01-0003-1987 dan standar yang ditetapkan PTPN IV Unit Usaha Pabatu. Hasil uji mutu kadar air dan kadar kotoran belum memenuhi (melebihi dari standar mutu) SNI 01-0003-1987 dan standar mutu yang ditetapkan oleh PTPN IV Unit Usaha Pabatu.
Pelatihan Penggunaan Aplikasi Pengendali Mutu Dalam Pengemasan Air Minum Dalam Botol Berbasis Image Processing
Authors: Rozikin Chaerur , Suharso Aries , Kusnadi Kusnadi , Enri Ultach , Indahsari Dhea 
Published: July 2022

Dalam dunia perindustrian, kualitas atau mutu produk dan produktivitas adalah kunci keberhasilan bagi berbagai sistem produksi (Parwati & Sakti, 2012). Kontrol terhadap mutu produk bertujuan untuk meminimalkan hasil produk yang cacat (Hariastuti, 2015). Pelatihan dilakukan untuk meningkatkan kemampuan dan pengetahuan mengenai penggunaan aplikasi pengendali mutu dalam pengemasan air minum yang lebih mudah dan praktis. Metode pelaksanaan pengabdian dilakukan dengan cara pelatihan terhadap 30 Mahasiswa Universitas Singaperbangsa Karawang. PelatihanÂ dilaksanakan dengan melakukan kegiatan demonstrasi mengenai aplikasi yang digunakan sebagai pengendali mutu dalam pengemasan air minum dalam botol berbasis image processing. Aplikasi ini berfungsi untuk menghitung jumlah botol dalam kardus, sehingga lebih akurat dan meminimalisir kurangnya jumlah botol di dalam kardus yang akan didistribusikan kepada konsumen. Hasil dari pelatihan ini adalah meningkatnya pengetahuan dan kemampuan peserta dalam menggunakan aplikasi pengendali mutu dalam pengemasan air minum dalam botol berbasis image processing yang ditunjukan dengan kenaikan rata-rata hasil kuesioner mengenai aplikasi dari 43,6% menjadi 92,8%.
FAKTOR–FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU SEKS BEBAS PADA REMAJA DI STIKES ABDI NUSANTARA TAHUN 2021
Authors: Maimunah  , Rani Suryani  
Published: July 2022

Latar Belakang : Seks bebas adalah hubungan yang didorong oleh hasrat seksual, baik dari lawan jeni satau sesama jenis yang dilakukan pada pasangan tanpa adanya suatu ikatan pernikahan.
Tujuan Penelitian : Untuk mengetahui faktor-faktor yang berhubungan dengan perilaku seks bebas pada remaja di Stikes Abdi Nusantara tahun 2021.
Metode : Penelitian ini menggunakan pendekatan kuantitatif dengan desain penelitian cross sectional. Jumlah populasi dalam penelitian ini sebanyak 56 responden dan tehnik pengambilan sampel total sampling dengan jumlah sampel 56 responden. Intrumen dalam penelitian ini yaitu kuesioner. Analisis yang digunakan yaitu analisis univariat dan bivariate
Hasil : Hasil penelitian menunjukan bahwa ada hubungan pengetahuan dengan perilaku seks bebas pada remaja dengan p value 0,000. Ada hubungan umur dengan perilaku seks bebas dengan p value 0,000. Ada hubungan peran orang tua dengan perilaku seks bebas dengan p value 0,000. Ada hubungan sumber informasi dengan perilaku seks bebas dengan p value 0,000.
Kesimpulan dan Saran : Diharapkan remaja lebih meningkatkan pengetahuan mengenai dampak seks bebas sehingga akan mengurangi keinginan untuk melakukan seks bebas.
REVIEW : POTENSI KOPI ARABIKA (Coffea arabica L.) DARI BERBAGAI AKTIVITAS FARMAKOLOGI & BENTUK SEDIAAN FARMASI
Authors: Muharam Firman , Sriwidodo  
Published: July 2022

Kopi Arabika (Coffea arabica L.) adalah tanaman yang memiliki populasi cukup banyak di Indonesia dan merupakan salah satu komoditas di dunia. Kopi arabika memiliki aktivitas sebagai antiinflamasi, antihiperglikemik, antiselulit, hiperurisemia, antimikroba, dan antioksidan. Hal ini mengindikasikan kopi arabika (Coffea arabica L.) memiliki bahan aktif atau metabolit sekunder seperti kafein dan asam klorogenat yang memberikan aktivitas tersebut. Penggunaan kopi arabika (Coffea arabica L.) pada kalangan masyarakat terbatas pada obat herbal dan juga minuman dengan pengolahan standar sehingga saat ini banyak dikembangkan ulasan mengenai formulasi dan inovasi dari kopi arabika (Coffea arabica L.) sehingga lebih memberikan aktivitas terapi. Pada review artikel ini akan diulas secara lengkap mengenai kopi arabika (Coffea arabica L.) dalam hal kandungan kimia, aktivitas, dan formulasi yang telah dikembangkan pada kopi arabika (Coffea arabica L.). Kopi arabika (Coffea arabica L.) memiliki potensi untuk dikembangkan sebagai bahan aktif berdasarkan tinjauan tentang efektivitas kopi arabika (Coffea arabica L.).
The Substructures in the Anticenter Region of the Milky Way
Authors: Zhang Z. , Shi W. B. , Chen Y. Q. , Zhao G. , Carrell K. , Zhang H. P. 
Published: July 2022

Abstract
We investigated the observational properties of Triangulum-Andromeda (TriAnd), Monoceros Ring (MRi), and Anti-Center Stream (ACS) in the anticenter region using K giants, M giants, and RGB stars from LAMOST and SDSS survey. The Friends of Friends algorithm was applied to select member stars of these structures. We found a new spur of TriAnd at l ∼ 133° based on member stars selected in this work and compiled from the literature. The distributions of radial velocity and proper motion of its member stars indicate that TriAnd is gradually moving away from the Sun. The comparisons of [Fe/H] and [α/Fe] between TriAnd and thick-disk/halo stars reveal that TriAnd is likely to originate from the thick disk. MRi and ACS are adjacent in space with a boundary around latitude 30°, and there is no significant difference between the two structures in velocity, proper motions, and orbits. We suggested that MRi and ACS probably have a common origin. We made projections of the four structures in three-dimensional space for the exploration of the movements between the Sagittarius (Sgr) stellar stream and MRi, and found that a new spur was formed by the Sgr stream members in the velocity distribution as it passed through the MRi region.
Extragalactic Magnetic Fields and the Arrival Direction of Ultra-high-energy Cosmic Rays
Authors: de Oliveira Cainã , de Souza Vitor 
Published: July 2022

Abstract
We studied the propagation of ultra-high-energy cosmic rays in extragalactic magnetic fields (EGMFs). We report on the effect of the EGMF on the large-scale anisotropy signal measured at Earth. We show how a spurious dipolar and quadrupolar signal can be generated by the EGMF even if the source distribution is isotropic.
The Common Envelope Evolution Outcome—A Case Study on Hot Subdwarf B Stars
Authors: Ge Hongwei , Tout Christopher A. , Chen Xuefei , Kruckow Matthias U. , Chen Hailiang , Jiang Dengkai , Li Zhenwei , Liu Zhengwei , Han Zhanwen 
Published: July 2022

Abstract
Common envelope evolution (CEE) physics plays a fundamental role in the formation of binary systems, such as merging stellar gravitational wave sources, pulsar binaries, and Type Ia supernovae. A precisely constrained CEE has become more important in the age of large surveys and gravitational wave detectors. We use an adiabatic mass-loss model to explore how the total energy of the donor changes as a function of the remnant mass. This provides a more self-consistent way to calculate the binding energy of the donor. For comparison, we also calculate the binding energy through integrating the total energy from the core to the surface. The outcome of CEE is constrained by total energy conservation at the point at which both components’ radii shrink back within their Roche lobes. We apply our results to 142 hot subdwarf binaries. For shorter orbital period hot subdwarf B stars (sdBs), the binding energy is highly consistent. For longer orbital period sdBs in our samples, the binding energy can differ by up to a factor of 2. The common envelope (CE) efficiency parameter β
CE becomes smaller than α
CE for the final orbital period

log

10

P

orb

/

days
>
−
0.5

. We also find the mass ratios

log

10

q

and CE efficiency parameters

log

10

α

CE

and

log

10

β

CE

linearly correlate in sdBs, similarly to the findings of De Marco et al. for post-AGB binaries.
Searching for a Hypervelocity White Dwarf SN Ia Companion: A Proper-motion Survey of SN 1006
Authors: Shields Joshua V. , Kerzendorf Wolfgang , Hosek Matthew W. , Shen Ken J. , Rest Armin , Do Tuan , Lu Jessica R. , Fullard Andrew G. , Strampelli Giovanni , Zenteno Alfredo 
Published: July 2022

Abstract
Type Ia supernovae (SNe Ia) are securely understood to come from the thermonuclear explosion of a white dwarf as a result of binary interaction, but the nature of that binary interaction and the secondary object is uncertain. Recently, a double white dwarf model known as the dynamically driven double-degenerate double-detonation (D6) model has become a promising explanation for these events. One realization of this scenario predicts that the companion may survive the explosion and reside within the remnant as a fast moving (V
peculiar > 1000 km s−1), overluminous (L > 0.1 L
⊙) white dwarf. Recently, three objects that appear to have these unusual properties have been discovered in the Gaia survey. We obtained photometric observations of the SN Ia remnant SN 1006 with the Dark Energy Camera over four years to attempt to discover a similar star. We present a deep, high-precision astrometric proper-motion survey of the interior stellar population of the remnant. We rule out the existence of a high-proper-motion object consistent with our tested realization of the D6 scenario (V
transverse > 600 km s−1 with m

r
< 21 corresponding to an intrinsic luminosity of L > 0.0176 L
⊙). We conclude that such a star does not exist within the remnant or is hidden from detection by either strong localized dust or the unlikely possibility of ejection from the binary system almost parallel to the line of sight.