bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxygen Uptake Response to Switching Stairs Exercise by Non-parametric Modeling
Authors: Su Steven , Yu Hairong , Xie Tian 
Published: February 2022

Abstract

Background: Oxygen uptake plays a vital role in evaluating endurance performance during exercise and is widely used for metabolic assessment. In order to guarantee the accuracy of oxygen uptake estimation, suitable modeling method applied to estimating cardiorespiratory response during interval training exercise should be investigated. Methods: In this study, the oxygen uptake during the exercise phase (i.e. ascending or descending) of the stairs exercise is recorded and the experimental dataset features ten participants and a range of different exercise periods. Based on the designed experiment protocol, a non-parametric modeling method with kernel-based regularization is generally applied to estimate the oxygen uptake changes during the interval stairs exercise that is close to the daily life status. Results: The non-parametric model exhibits the smallest variance and higher accuracy than fixed-order models in both one period and two periods during exercise. Moreover, the fitness of two periods is significantly lower than those of half or one period for the non-parametric model and the IR model is quite different in different periods, which indicates that the model of the system is changing with exercise periods. Conclusions: Compared with the fixed-order models on accuracy, stability and compatibility, the modeling results demonstrate the effectiveness of the non-parametric modeling approach. The influence of exercise duration on estimated fitness reveals that the model of the phase-oxygen uptake system is not time-invariant related to respiratory metabolism regulation and muscle fatigue. Accordingly, it allows us to study the humans’ conversion mechanism at different metabolic rates and facilitates the standardization and development of exercise prescriptions.
MMP-9 plasma level as a biomarker of cochlear implantation outcome in cohort study of deaf children
Authors: Matusiak Monika , Oziębło Dominika , Ołdak Monika , Rejmak Emilia , Dobek Domink , Kaczmarek Leszek , Skarżyński Henryk 
Published: February 2022

Abstract

Objective: If before cochlear implantation it was possible to assay biomarkers of neuroplasticity, it might identify those children with congenital deafness who were at risk of poor speech and language rehabilitation outcomes later on. Study Design: a prospective cohort study Methods: a group of 40 children aged up to 2 years old with DFNB1-reated congenital deafness was observed over three follow-up intervals up to 18 months after cochlear implant (CI) activation. Children were assessed for auditory development by using the LittlEARS Questionnaire (LEAQ) score and at the same time measurements were made of matrix metalloproteinase-9 (MMP-9) plasma levels. Results: There were significant negative correlations between plasma levels of MMP-9 at 8 months follow-up and LEAQ score at cochlear implantation (p = 0.04) and LEAQ score at 18 months follow-up (p = 0.02) and between MMP-9 plasma levels at 18 months follow-up and LEAQ score at cochlear implantation (p = 0.04). As already reported, we confirmed a significant negative correlation between MMP-9 plasma level at cochlear implantation and LEAQ score at 18 months follow-up (p = 0.005). Based on this latter correlation, two clusters of good and poor CI performers could be isolated. Conclusions: The study shows that children born deaf who have an MMP-9 plasma level of less than 150 ng/ml at cochlear implantation have a good chance of attaining a high LEAQ score after 18 months of speech and language rehabilitation. This indicates that MMP-9 plasma level at cochlear implantation is a good prognostic marker for CI outcome.
Comparative assessment of two behavioural risk factors (physical inactivity and unhealthy diet) among obese Bengalee women in rural and urban areas of West Bengal, India
Authors: Bose Chaitali , Sultana Julekha , Banerjee Oly , Singh Siddhartha , Mukherjee Sandip , Syamal Alak Kumar 
Published: February 2022

Abstract
Background:Unhealthy diet and physical inactivity are the behavioural risks, closely associated with obesity which is a metabolic risk leading to the development of Non Communicable Diseases (NCDs). Dietary transition and sedentary living is also significant even in rural India which might be accountable to uprising NCDs there. So the aim of our study was to assess dietary pattern and unhealthy dietary factors, to determine the prevalence of physical inactivity among obese bengalee women in rural and urban areas of West BengalMethods:This study was conducted in Hooghly district of West Bengal, India and 150 female subjects (75 from rural area and 75 from urban area) of 20-40 years age group were recruited for the study considering inclusion and exclusion criteria. Different physical and socio-demographic variables were measured and dietary information was collected using questionnaire. Global Physical Activity Questionnaire (GPAQ) was used to collect information about physical activities of the study participants. Different anthropometric parameters (body weight, height, Body Mass Index [BMI], waist circumference [WC], hip circumference [HC], waist to hip ratio [WHR] and waist to height ratio [WHtR]) were measures as the strong prediction tools for assessing their risks related to NCDs.Results:We found that most of the daily energy comes from carbohydrate in the diet of both groups, consumption of food groups like animal protein and dairy products, fruits, visible fat and sugar were significantly higher in urban group whereas dietary fibre, green leafy and other vegetables, pulses and nuts intake was significantly high in rural group. Physical inactivity prevalence was 64% in rural and 78.7% in urban and there was significant difference between rural and urban group regard to all the anthropometric indices.Conclusions:In summary, the behavioural risk factors those were assessed are undoubtedly apprehensive and anthropometric indices are pointing out towards associated possible metabolic risks which were poorer in urban group than rural, so further clinical investigation along with proper intervention measure is indispensible.
An Optimization Algorithm for Interdependent Tasks and Variable Task Queues under the Dynamic Resources Pool
Authors: TSUI Lanyi 
Published: February 2022

Abstract
In the era of data transformation, the timeliness needed to be ensured and avoid the system downtime caused by task congestion as well, which puts forward higher requirements for the system stability and the intelligence of task scheduling. However, the manual maintenance which used to be adopted for IT batch or scheduling in data center and jobs platform domain cannot meet the requirements. For instance, existing methods of task scheduling lack some valid scheduling standards in face of thousands of tasks or relatively complicate dependencies. Therefore, task scheduling ought to do automated assignments instead of manual configuration in order to solve the problem of task congestion and achieve an appropriate allocation of resources. Firstly, we establish a mapping model between real-time resources pool and fluctuating hardware resources, and we conduct a prediction function for resources by algorithm. Then we quantify the resource consumption of each task and intelligently assign each of tasks to an appropriate segment of resource units. In addition, we propose a model that is composed of function of task dependencies and function of intelligent allocation to ensure the order of task execution to avoid deadlock and recursion. Finally, we develop a program to automatically allocate task sequences to resource clusters. This program can intelligently schedule tasks to improve system stability and solve the problem of task congestion. In conclusion, our algorithm has a significant effect in the following aspects: 1) Our algorithm reduces the resources consumed by the task queue,saves the 50 daily computing hours for average task and improves the operational efficiency by 400%. 2) The algorithm significantly reduced the fluctuation range. The CPUtime of a task daily fluctuates between approximately + 5% and − 5% now, compared with about 300% before. 3) The model makes the task number curve smoother and more uniform after the algorithm intervention.
MiR-323a regulates ERBB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer
Authors: zhang yuanzhou , liang shunshun , Xiao Bowen , hu jingying , pang yechun , liu yuling , yang juan , ao junping , wei lin , Luo Xiaoying 
Published: February 2022

Abstract
The rapid onset of resistance to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) limits its clinical utility in colorectal cancer (CRC) patients, and pan-erb-b2 receptor tyrosine kinase (ErbB) treatment strategy may be the alternative solution. The aim of this study was to develop a possible microRNA multi-ErbB treatment strategy to overcome EGFR-TKI resistance. We detect the receptor tyrosine kinase activity in gefitinib-resistant colorectal cancer cells, ErbB3/EGFR is significantly activated and provides a potential multi-ErbB treatment target. MiR-323a-3p, a tumor suppressor, could target both ErbB3 and EGFR directly. Apoptosis is the miR-323a-3p inducing main biological process by functional enrichment analysis, and The EGFR and ErbB signaling are the miR-323a-3p inducing main pathway by KEGG analysis. MiR-323a-3p promotes CRC cells apoptosis by targeting ErbB3-phosphoinositide 3-kinases (PI3K)/PKB protein kinase (Akt)/glycogen synthase kinase 3 beta (GSK3β)/EGFR-extracellular regulated MAP kinase (Erk1/2) signaling directly. And miR-323a-3p, as a multi-ErbBs inhibitor, increase gefitinib sensitivity of the primary cell culture from combination miR-323a-3p and gefitinib treated subcutaneous tumors. MiR-323a-3p reverses ErbB3/EGFR signaling activation in gefitinib-resistant CRC cell lines and blocks acquired gefitinib resistance.
Global ENSO Modulation of MJO and its Impacts on South America
Authors: Fernandes Laís G. , Grimm Alice Marlene 
Published: February 2022

Abstract
Changes in the Madden-Julian Oscillation (MJO) and its impacts on the South American monsoon season during different El Niño-Southern Oscillation (ENSO) states (El Niño – EN, La Niña – LN, neutral – NT) are analyzed in the global context of the MJO propagating anomalies of convection and circulation. The background ENSO-related anomalies influence several aspects of MJO (relative occurrence of phases, propagation, convection and teleconnections), and therefore modify the MJO impacts on South America (SA), such as precipitation anomalies and frequency of extreme events, as well as their temporal distribution throughout the MJO cycle. Changes include: (1) a delay in the peak of the teleconnections between central-eastern Pacific and SA, from MJOphase8 in LN to MJOphase1 in EN; (2) enhanced MJO convection in the central-east subtropical South Pacific in MJOLNphases7+8 and a little further east in MJOENphases8+1, in a region efficient in generating tropics-extratropics teleconnections to SA, producing rainfall anomalies over Central-East SA (CESA), especially the South Atlantic Convergence Zone (SACZ), strongest one phase earlier in LN (MJOLNphase8) than in EN (MJOENphase1), and a little shifted east in the latter than in the former; (3) predominant increase (or reduction) in the frequency of extreme events over densely populated SA regions where both ENSO and MJO contribute in the same direction, with the greatest increase over CESA (including SACZ) during EN, in MJOENphase1, and over Southeast SA (SESA), in MJOENphase3; (4) enhanced amplitude in both states, EN and LN, of the first continental intraseasonal dipole-like mode of precipitation variability between CESA and SESA, with maximum opposite anomalies in CESA, the center with largest amplitude, in phases 1 and 4 for EN, and phases 8 and 5 for LN. Significant effects can also be observed in other regions, as northeast and northwest SA.
Pressure-induced monotonic enhancement of Tc to over 30 K in the superconducting Pr0.82Sr0.18NiO2 thin films
Authors: Wang Ningning , Yang Mingwei , Yang Zhen , Chen Keyu , Zhang Hua , Zhang Q. H. , Zhu Zhihai , Uwatoko Yoshiya , Gu L. , Dong Xiaoli , Sun Jianping , Jin Kuijuan , Cheng Jinguang 
Published: February 2022

Abstract
The successful synthesis of superconducting infinite-layer nickelate thin films with the highest Tc ~ 15 K has reignited great enthusiasms on this family of potential analogue to high-Tc cuprates. Pursuing a higher Tc is always an imperative task in studying a new superconducting material system. Here we report high-quality Pr0.82Sr0.18NiO2 thin films with Tconset ~ 17 K synthesized by carefully tuning the amount of CaH2 in the topological chemical reduction and the effect of pressure on its superconducting properties by measuring electrical resistivity under various pressures in a cubic anvil cell apparatus. We find that the onset temperature of the superconductivity, Tconset, can be enhanced monotonically from ~ 17 K at ambient pressure to ~ 31 K at 12.1 GPa without showing signatures of saturation upon increasing pressure. This encouraging result indicates that the Tc of infinite-layer nickelates superconductors still has room to go higher and it can be further boosted by applying higher pressures or strain engineering in the heterostructure films.
The concentration and prevalence of asbestos fibres in Christchurch, New Zealand's drinking water supply
Authors: Mager S. , Knopick M. , Oddy G. 
Published: February 2022

Abstract
Asbestos cement was a common construction material for water pipes during the twentieth century, as a replacement for metal piping that was vulnerable to corrosion. We report on the presence of asbestos fibres in drinking water supply in Christchurch, New Zealand from ageing asbestos cement reticulated water supply. By sampling the mains water supply via hydrants, 19 of our 20 samples showed long asbestos fibres (&gt;10 μm), with an average concentration 0.9 million fibres per litre (MFL). Short asbestos fibres (&gt;0.5 μm) had an average concentration of 6.2 MFL. Sampling was targeted to pipes from 1930 to the 1960s and there was abundant evidence of fibres being released from pipes of this age. Municipalities cannot continue to rely on ageing asbestos-cement piping, as it appears to be releasing asbestos fibres into drinking water with uncertain health implications, and should prioritise replacing pipes greater than 50 years in age, especially where high water pressures or land disturbance occur, to reduce the risk of water-carried asbestos being released into urban environments, and mitigate any risk of asbestos from ingested contaminated water sources.
A coastal reservoir for Greater Sydney water supply in Shoalhaven river – a preliminary study
Authors: Ji Rong , Yang Shu-Qing , Sivakumar Muttucumaru , Enever Keith , Bin Riaz Muhammad Zain , Khalil Usman 
Published: February 2022

Abstract
Australia is the driest inhabited continent on earth, and most of its population is concentrated along the coastal line. In recent years, extreme climate events such as floods and droughts have occurred more frequently. Sydney, as the largest city in Australia, requires a reliable water supply. Many solutions have been conducted to secure its water supply. This paper is focused on future water supply for the Greater Sydney area. The analysis supports the concept that in runoff-rich regions like Greater Sydney, there is no water shortage but a lack of water storage. The novel technology, coastal reservoirs, can increase the storage capacity of freshwater in the sea. The average annual discharge at Shoalhaven River mouth is estimated as 1,334 gigalitres. By comparison, the average annual inflow to the Warragamba Dam, which supplies 80% of Sydney's drinking water, is 1,069 gigalitres. This paper discusses how to apply a Coastal Reservoir at the Shoalhaven River mouth to secure additional water supply for ever-growing Greater Sydney. The proposed reservoir with a capacity of 500 gigalitres could supply 1,000 gigalitres of water per year with a reliability of 90%. A preliminary design of the reservoir is demonstrated.
Research on real-time risk monitoring model along the water transfer project: a case study in China
Authors: Wang Fang , Liu Bing , Li Hongen , He Yongjun 
Published: February 2022

Abstract
With the continuous operation of a water transfer project, especially under the general trend of global climate change in recent years, extreme weather occurs frequently, and the project's operation process will be tested by natural disasters, structural damage, electromechanical equipment failure, water pollution and other risks. Therefore, the risk management of the water transfer project is of great significance to ensure the long-term operation of the project. As one of the four largest cross-century projects in China, the operation risk of the South-to-North Water Transfer Project has attracted great attention. In this paper, a system dynamic model (SDM) for simulating real-time risk is presented. Based on the linear and directional characteristics of water transfer project and the known risk level of single buildings, DYNAMO language is embedded to connect the risks of various points on the line, and a model for real-time monitoring the risk changes along the line is constructed. The what-if analysis performed by the SDM shows the importance of human intervention to the deterioration and spread of dangerous situations in the process of engineering damage.
Nutraceutical Potential of High-latitude and High-altitude Berries Rich in Ellagitannins
Authors: Burlando Bruno , Cornara Laura , Boggia Raffaella 
Published: February 2022

Introduction:This review concerns three species of berries, namely the high- -latitude cloudberry (Rubus chamaemorus) and arctic bramble (Rubus arcticus), and the high-altitude yellow raspberry (Rubus ellipticus). These plants are mostly exploited on a local basis as food or traditional remedies but could have a wider usage as nutraceuticals due to their richness in ellagitannins (ETs) and other phenolic compounds. ETs are hexahydroxydiphenoyl esters of carbohydrates and the largest group of hydrolysable tannins. They are distinctly antioxidant and bioactive compounds, and therefore, are considered as majorly responsible for the biological properties of ET-rich berries. The health benefits of ETs are mainly due to the release of ellagic acid and to their metabolic transformation by the gut microbiota into urolithins, and include, among others, anti-inflammatory, antiviral, anti-bacterial, and anticancer actions.Methods:Based on the literature searches in the Web of Science, Scopus, and PubMed databases, ethnobotanical, pharmaceutical, medicinal, and nutritional knowledge concerning the three berry species was covered. This includes empirical use of traditional preparations and experimental studies with various extracts and fractions from fruits and other plant portions, covering in vitro, preclinical, and clinical research.Results:The data reveal a wide spectrum of potential uses in health care, providing in some cases an experimental confirmation of traditional uses.Conclusions:The examined berry species can act as nutraceutical foods, having positive effects on regular consumers but could also be exploited in more technological ways to produce food complements from ET-rich extracts.
Recent Advances in the Selection of Cancer-Specific Aptamers for the
Development of Biosensors
Authors: Sousa Diana A. , Carneiro Mariana , Ferreira Débora , Moreira Felismina T.C. , Sales Maria Goreti F. , Rodrigues Lígia R. 
Published: February 2022

Abstract:
An early diagnosis has the potential to greatly decrease cancer mortality. For
that purpose, specific cancer biomarkers have been molecularly targeted by aptamer sequences
to enable an accurate and rapid detection. Aptamer-based biosensors for cancer
diagnostics are a promising alternative to those using antibodies, due to their high affinity
and specificity to the target molecules and advantageous production. Synthetic nucleic
acid aptamers are generated by in vitro Systematic Evolution of Ligands by Exponential
enrichment (SELEX) methodologies that have been improved over the years to enhance
the efficacy and shorten the selection process. Aptamers have been successfully applied
in electrochemical, optical, photoelectrochemical and piezoelectrical-based detection
strategies. These aptasensors comprise a sensitive, accurate and inexpensive option for
cancer detection being used as point-of-care devices. This review highlights the recent advances
in cancer biomarkers, achievements and optimizations made in aptamer selection,
as well as the different aptasensors developed for the detection of several cancer biomarkers.
Mini review on the synthetic methodology of citric acid functionalized magnetic graphene oxide characterization and its implementation in waste water treatment
Authors: Sharma Shobhana 
Published: February 2022

Abstract:
Water is an essential element for day-to-day activities like agriculture, industry and domestic uses, etc for human beings. Now-a-day, water pollution by heavy metal ion is one of the most crucial environmental issues. Various methods like ion exchange, chemical precipitation, coagulation, flocculation, membrane filtration, adsorption, and flotation have been adopted to get rid of heavy metal ions from the waste water. Among all these methods, the adsorption process has been widely used for the elimination of heavy metals due to its environment friendly, cost-effective nature and easier availability. The commercial adsorbents, bioadsorbents, and nanosorbents possess high removal capacity, thus used for the eradication of heavy metals from waste water. In recent years, nanosorbents are used in environmental remediation as it occupies large surface area and high substance specificity. The present review aims to assemble the role of citric acid functionalized magnetic graphene oxide in waste water treatment. The presence of functional groups like citric acid, Fe2O3 on graphene oxide holds ample of sites which lead increase its surface area and enhance its adsorptivity. The magnetic nature of graphene oxide provides good dispersity in water and makes it easily separable.
Current Synthetic Methodologies of Carbon Nanotubes: A Review
Authors: sharma Shobhana 
Published: February 2022

Abstract:Carbon Nanotubes (CNTs) possess a unique one-dimensional molecular geometry with a large surface area. Recently, CNTs have become a thrust area of research as they play a crucial role in molecular engineering due to their excellent mechanical, electrical, and thermal properties. CNTs have a wide range of applications in various fields due to their unique properties. The Multiple Walled Carbon Nanotubes (MWCNTs) are thermally, mechanically, and structurally stronger than single-walled carbon nanotubes (SWCNTs). The sublimation of carbon in an inert atmosphere is the basis of synthetic methods of CNTs like the solar method, laser ablation, and electric arc discharge. Specific chemical methods like CVD, electrolysis, catalytic decomposition of hydrocarbons, heat treatment of a polymer, ball milling, etc., can also be used to prepare CNTs. Attempts have been made in the present review to discuss all synthetic methods of CNTs, their discoverers, the importance of techniques, various parameters that affect the process in detail, and the mechanism for the growth of CNTs. This article aims to provide a comprehensive pathway for researchers who deal with the synthetic methodology of carbon nanotubes. This review is also interesting for readers of material science and nanochemistry.