bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’entreprise au(x) défi(s) de l’alimentation confessionnelle : réactions individuelles, dilemmes organisationnels et recherche du commun
Authors: Gaillard Hugo 
Published: January 2022

Cette recherche concerne l’expression religieuse au travail et son management, et particulièrement la question des demandes de menus confessionnels. Nous abordons cette question par le biais d’une étude qualitative par entretiens et une analyse documentaire qui vise à caractériser les réactions empiriquement associées à un projet réel ou supposé de mise en œuvre de tels menus dans les organisations des individus, et les dilemmes éthiques qu’induisent de tels questionnements pour les décideurs. Les résultats démontrent que les réactions s’inscrivent sur un continuum en onze types de quatre natures différentes : du favorable, en passant par le sceptique et le neutre jusqu’au défavorable. Les réactions apparaissent plus diverses dans leur aspect négatif, et émanent des collaborateurs concernés et non concernés par ce type de consommation. Enfin, sont présentés les dilemmes éthiques des organisations lorsqu’elles abordent cette question ou qu’elles y sont confrontées. La tension est forte entre le souhait d’inclure et la crainte de détruire le commun, par ce même processus. Notre travail abouti sur des recommandations managériales, en faveur d’une stratégie de terrain commun.
La Turquie et la Méditerranée. Une relation houleuse
Authors: Josseran Tancrède 
Published: January 2022

La défaite politique des gülenistes a provoqué le retour en force des kémalistes dans la réflexion stratégique turque. Ces derniers sont aujourd’hui les principaux promoteurs de la doctrine maritime et navale de la Patrie bleue. Néanmoins, l’entente entre islamo-conservateurs et ulusalcı demeure fragile. Deux handicaps freinent Ankara dans sa quête thalassocra­tique : la Turquie reste une puissance d’abord littorale et non océanique. D’autre part, elle ne dispose pas d’une marine marchande véritable capable d’exporter la richesse nationale. Alors que la Grèce se hisse au 12 e rang des marines marchande, la Turquie se classe à la 18 e place. Si elle n’est pas déshonorante, ce rang demeure décevant. En dépit d’efforts constants, d’une volonté réelle, l’éveil océanique turc s’avère encore difficile.
Théâtre et éducation humaniste dans les collèges (XVIe et XVIIe siècles)
Authors: Mazouer Charles 
Published: January 2022

Est rappelé d’abord ce que représente l’humanisme et sa pénétration dans les collèges, pour définir l’éducation humaniste. Les collèges, où le théâtre est une activité ancienne, continuent de favoriser le théâtre scolaire quand ils sont devenus des foyers de l’humanisme. On s’attarde enfin sur le théâtre des jésuites : règles, visées, répertoire, représentations.
Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis
Authors: Fahl Shawn P , Sertori Robert , Zhang Yong , Contreras Alejandra V , Harris Bryan , Wang Minshi , Perrigoue Jacqueline , Balachandran Siddharth , Kennedy Brian K , Wiest David L 
Published: January 2022

Abstract
Ribosomal proteins are thought to primarily facilitate biogenesis of the ribosome and its ability to synthesize protein. However, in this study, we show that Rpl22-like1 (Rpl22l1) regulates hematopoiesis without affecting ribosome biogenesis or bulk protein synthesis. Conditional loss of murine Rpl22l1 using stage or lineage-restricted Cre drivers impairs development of several hematopoietic lineages. Specifically, Tie2-Cre–mediated ablation of Rpl22l1 in hemogenic endothelium impairs the emergence of embryonic hematopoietic stem cells. Ablation of Rpl22l1 in late fetal liver progenitors impairs the development of B lineage progenitors at the pre-B stage and development of T cells at the CD44−CD25+ double-negative stage. In vivo labeling with O-propargyl-puromycin revealed that protein synthesis at the stages of arrest was not altered, indicating that the ribosome biogenesis and function were not generally compromised. The developmental arrest was associated with p53 activation, suggesting that the arrest may be p53-dependent. Indeed, development of both B and T lymphocytes was rescued by p53 deficiency. p53 induction was not accompanied by DNA damage as indicated by phospho-γH2AX induction or endoplasmic reticulum stress, as measured by phosphorylation of EIF2α, thereby excluding the known likely p53 inducers as causal. Finally, the developmental arrest of T cells was not rescued by elimination of the Rpl22l1 paralog, Rpl22, as we had previously found for the emergence of hematopoietic stem cells. This indicates that Rpl22 and Rpl22l1 play distinct and essential roles in supporting B and T cell development.
Determinants of Wellbeing among Agroforestry Farmers in Edo State, Nigeria
Authors: Ojedokun C. A , Akinbile L. A , Ugege B.H , Adebayo D.O 
Published: January 2022

A fundamental concern of any government is the wellbeing of its citizens. Therefore, this study seeks to investigate the determinants of wellbeing among agroforestry farmers in Edo state, Nigeria. Respondents were selected using a multi-stage sampling procedure to select three forest enclaves based on the number of agroforestry farmers in the enclaves. These enclaves are Sakponba, Ubiaja and Agbede using 50%, 33%and 17% respectively, this percentage was based on the population of the enclave dwellers in each using simple random sampling, and a total of 120 respondents was obtained; data were analysed using descriptive and inferential statistics such as multinomial logit and multiple regression. The result reveals that the mean age of the farmers was 45.6years. Majority (85.8 %) were male and 78.3% were married. The mean household size was 5 persons, with 54.2% having household size of between 4 and 6 persons. Majority (84.2%) had formal education. Also, 65.8% had agroforestry farming as primary occupation, with source of income as main reason for involvement in agroforestry and average farm size of 8.4 hectares. Results of multiple regression analysis for relationship between contribution of the independent variable and farmers’ wellbeing reveals a positive and significant relationship between farmers’ level of income; economic and material wellbeing are not signific ant at any alpha level, social wellbeing (r = 0.217, P ≤ 0.10) and psychological wellbeing (r = 0.283, P ≤0.05), respectively. The positive and significant relationship implies that the higher the farmers’ income level, the higher the economic, social and psychological wellbeing of the farmers. The study therefore, recommends that agroforestry support services like incentives, agricultural inputs and provision of soft loans should be provided by government and various NGOs to improve farmers’ income.
Keywords: Determinants, Agroforestry, Wellbeing, Farmers, Edo State
Evaluation of the Downtime of Radiological Equipment in Kano Metropolis, Nigeria
Authors: Sidi Mohammed , Galadanchi Khalifa Kabir 
Published: January 2022

Radiology equipment should have minimal downtime and provide outputs of high reliability to ensure prompt and accurate diagnosis. Prolonged downtime affects the moral, productivity of radiographers, radiologists and patients are unduly delayed in accessing radiological services. The study was aimed at evaluating the downtime of the radiological equipment in Kano metropolis, Nigeria. The study design was retrospective conducted in some selected hospitals and a private center in the Kano metropolis from April 2019 to November 2019. An ethical approval to conduct the study was obtained from the Human Research and Ethics Committee of the Kano State Ministry of Health. Purposive sampling method was used in selecting the hospitals and the private center. The model, year of installation and the downtime obtained from the records of all the selected equipment was recorded on the data capture sheet. Center I had the highest frequency of equipment breakdown (5times) while center IV and VI had the lowest frequency of breakdown (once). The equipment with the most prolonged and second most prolonged was found in Center IV (10years, 6months and 7years, 3 months). The equipment with the shortest downtime was found in Center II (1day) and the second shortest was found in Center III and VI (1week) each. X-ray machines had the most prolonged downtime followed by CT. MRI had the shortest downtime. Radiological equipment in Kano metropolis is associated with frequent breakdown and prolonged downtime.
Keywords: Downtime, Radiological Equipment, Kano metropolis
The Influence of Household Size on Growth Pattern of Children Aged 5-12 Years from Kazaure Emirate, Jigawa State, Nigeria
Authors: Gudaji A. , Danborno B. 
Published: January 2022

Anthropometry is the measurement of different parts of the body and is an indicator of nutritional and health status. Socio-economic variables such as income, education, birth order, family size, and urbanization are associated with the physical development of children. The aim of the study was to determine the influence of house-hold (family) size on the growth pattern of children aged 5-12 years from Kazaure emirate, Jigawa State, Nigeria. A stadiometer was used to measure height to the nearest 0.1 cm and weight to the nearest 0.5 kg. A non-elastic measuring tape was used for the measurement of head, neck, chest, mid upper arm, hip, waist and calf circumferences to the nearest 0.1cm respectively. A Harpenden skin fold caliper was used for the measurement of biceps and triceps skin fold thicknesses to the nearest 0.1 mm respectively. It was a cross-sectional survey comprising of 863 pupils of Hausa ethnic group randomly selected from public primary schools in Kazaure emirate aged 5 - 12years. Males of household size between1-2, had higher values of HT, WT and body circumferences than females except hip circumference with statistical significant difference p<0.05 while females had higher values of biceps and triceps skinfold thicknesses with statistical difference p<0.05. Males of household size >2, had higher values of HT, WT, BMI and body circumferences than females with statistical difference (p<0.05) while females had higher values of skinfold thickness and HC with statistical difference (p=0.01). Males of household size 1-2, had higher values of cephalofacial dimensions than females with statistical difference (p<0.05) while females had higher values of nasal height and cephalic index than males with statistical difference p<0.05. Males of household size >2, had higher values of cephalofacial dimensions than females with statistical difference p<0.05 while females had higher values of NH and FI with statistical difference p<0.05. Males of household size 1-2 and >2, had higher values of upper and lower limbs dimensions than females with statistical difference p<0.05. In conclusion, it was observed that males grew better than females and, children from small family size had better growth than those from large family size.
Keywords: Age, Household-size, Growth, Kazaure emirate, Nigeria
Evaluation of the Relationship between Covid-19 Pandemic and Research Productivity among Academic and Medical Staff Of Public Universities and Hospitals in Nasarawa State, Nigeria
Authors: Allahnana Maikudi Kwanza , Ekpenyong Godhas U. , Ofoegbunam Ngozi Violet , Kukwi Isaac Jangson 
Published: January 2022

This study evaluates the relationship between COVID-19 pandemic and research productivity among academic and medical staff of public universities and hospitals in Nasarawa State, Nigeria. Correlational research design was used in this study. The researchers purposively used 2,543 respondents with 2 public universities and 2 public hospitals as the population of the study. Multistage random sampling technique was used to select 228 respondents with the same number of public universities and hospitals. The instrument used for data collection was COVID-19 Pandemic on Academic and Medical Staff Research Productivity (COVID-19 PAMSRP). The instrument was validated by the experts using e-face validity and the reliability index was 0.93 using Cronbach alpha method. Pearson Product Moment Correlation (r) was used for the analysis. The findings from the study revealed that, there was negative relationship between COVID-19 pandemic on academic and medical staff research productivity in Nasarawa State. By implication, COVID-19 pandemic affects both academic and medical staff. Based on the findings, it was recommended among others that both school and medical management should organize conferences, seminars and workshops for staff in such a way that it would improve the levels of their research productivity and services delivery for the safety of lives and Nigerian academics and medical staff should engage in reliable research that will lead to development and innovations for the improvement of education and health sectors.
Keywords: COVID-19 pandemic, research productivity
Farmer’s Adaptive Strategies To Climate Change in Akinyele Local Government Area, Oyo State, Nigeria
Authors: Bamigbade Ismaila Kolade , Ahmed Adamu , Ballama Muhammed , Onuoha Macdonald N 
Published: January 2022

Agriculture and climate change are inextricably linked to crop yield, biodiversity, water use, as well as soil health. The research sets the objectives of describing the socioeconomic characteristics of farmers in Akinyele L.G.A of Oyo state, identifying various adaptive measures and the determinants of appropriate climate-change adaptation measures used by farmers in the agricultural communities of the study area. A sample of farmers who have registered with the Federal Ministry of Agricultural, Growth Enhancement Support Scheme (GES) Akinyele chapter were recruited in the research. Questionnaire was used to gather data on the age, gender, education and farming experiences of the farmers. Data was also collected on these adaptive capacity measures: Membership of social organizations, mixed farming, change from crop production to animal rearing, seeking early warning information on climate change among others. Percentages, frequencies were used to analyze the data. The variables were also subjected to regression analysis.70% of the farmers in the study area are male and about the same percentage of them fall within the age range of 31-60 years. Only 33% of the farmers have post- primary education. The result of the regression analysis reveal that planting of improved varieties (0.841,0.001) intensive fertilizer/manure application (0.005,0.421) have positive and significant relationship in determining farmer’s adaptation strategies while contour ridging (1.950, 0.970) has positive but not significant relationship in determining farmer’s adaptation strategies .Change from crop production to animal rearing (-1.766, 0.567) has negative and insignificant relationship in determining farmer’s adaptation strategies
Keywords: Adaptation, Growth Enhancement Support Scheme, Strategies, Climate change, Communities
COMMENT: Adopted Child’s Right of Inheritance from the Family of Origin
Authors: Wondewosen Ewunie  
Published: January 2022

The relationship between adopted child and his/her family of adoption and family of origin is regulated under the Revised Family Code Proclamation No. 213/2000. Accordingly, the adopted child shall retain his/her bond with the family of origin in addition to his/her close relationship with the family of adoption by considering him/her, for all purposes, as the child of the adopter. One of the issues that arises in connection with a child’s relationship with his/her family of origin and family of adoption is the right to inheritance. In particular, the issue arises whether the adopted child can inherit his/her family of origin (through intestate succession) while s/he is deemed to be the child of the adopter and bestowed with all rights and duties including inheritance. The assurance of inheritance right to the adopted child from the estate of his/her family of origin depends upon how much the bond with his/her family of origin is maintained. This article focuses on the legal regime with regard to the adopted child’s relationship with his/her family of origin with particular emphasis on the adopted child’s right to inherit his/her family of origin, in Ethiopia.
LINC-ROR regulates myocardial ischemia/reperfusion injury via targeting of miR-129-5p/Hook3 axis
Authors: Chen Yan , Guan Qianqian , Feng Xiuyuan , Jiang Xuejun , Xu Guang , Hou Hongwei , Bike  
Published: January 2022

Purpose: To investigate the underlying mechanism of long intergenic non-protein coding RNA (LINC- ROR) in myocardial ischemia/reperfusion (I/R) injury.
Methods: Rat H9C2 cells were used to establish the model of hypoxia/reoxygenation (H/R). Cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The proportion of apoptotic H9C2 cells was evaluated using flow cytometry. Luciferase reporter experiments and RNA pull-down assays were used to determine the relationships among LINC-ROR, miR-129-5p, and hook microtubule tethering protein 3 (Hook3), while QRT-PCR and western blots were used to investigate the relationship between LINC-ROR and the expression and activation of Hook3 and proteins of the PI3K/AKT/mTOR pathway.
Results: LINC-ROR was elevated under H/R stimulation. The viability of H9C2 cells decreased, and cell apoptosis was induced after H/R treatment. These latter effects were abrogated by the down- regulation of LINC-ROR. Luciferase reporter results and RNA pull-down showed that LINC-ROR served as the miR-129-5p sponge, and miR-129-5p was bound to Hook3 RNA directly. Moreover, overexpression of LINC-ROR increased Hook3 protein level by serving as miR-129-5p sponge. Furthermore, the overexpression of LINC-ROR activated PI3K/Akt/mTOR pathway by regulating Hook3.
Conclusion: LINC-ROR increases in cardiomyocytes with H/R injury. Down-regulation of LINC-ROR alleviates myocardial I/R injury via miR-129-5p/Hook3 axis. Therefore, LINC-ROR is a potential therapeutic target for myocardial I/R injury.
Oridonin ameliorates depressive-like behaviors induced by chronic unpredictable mild stress in mice via TXNIP/NLRP3 signaling pathway
Authors: Wang Lina , Huang Ziye , Ping Jing , Liu XingYan , Cai Ziyao , Dai Chenghao 
Published: January 2022

Purpose: To investigate the effect and mechanism of oridonin in chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors.
Methods: CUMS was established using 6-week stress stimuli, including feed/water deprivation, night lighting, inverted light/dark cycle, and tail clamping. Depressive behaviors were analyzed using the sucrose preference test, forced swim test (FST), and tail suspension test (TST). Locomotor activity was analyzed using the open field test (OFT) while inflammatory cytokines were analyzed by enzyme-linked immunosorbent assay. The activation of the TXNIP/NLRP3 signaling pathway was evaluated by western blot.
Results: Sucrose consumption of CUMS-treated mice was significantly decreased, while immobility times of the FST (control vs. CUMS, ~50 to 150 s; p < 0.01) and TST (Control vs. CUMS, ~50 to 130 s; p < 0.01) were increased; oridonin significantly reversed these effects. Spontaneous locomotor activities (crossing, rearing, and grooming) measured in the OFT were decreased after the CUMS procedure, and oridonin increased these activities (p < 0.01 vs. CUMS). Oridonin decreased the production of tumor necrosis factor alpha, interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1 in the hippocampus of CUMS-treated mice and significantly inhibited activation of the TXNIP/NLRP3 pathway induced by CUMS.
Conclusion: Oridonin ameliorates depressive-like behaviors in mice induced by CUMS, partly via TXNIP/NLRP3 signaling pathway. Thus, the findings provide evidence for the potential application of oridonin in depression therapy.
Protective role of Bu-Zhong-Yi-Qi decoction on aristolochic acid-intoxicated zebrafish
Authors: Tsai Jen-Ning , Ding Yu-Ju , Lo Kang-Chieh , Lu Ping-Hsun , Chang Chiung-Fang , Wen Chi-Chung , Wang Bo-Cheng , Yang Ling-Ling , Chen Yau-Hung 
Published: January 2022

Purpose: To investigate the potential nephroprotective effects of a traditional Chinese medical prescription, Bu-Zhong-Yi-Qi Decoction (BZYQD) in an aristolochic acid (AA)-intoxicated zebrafish model.
Methods: A green fluorescent zebrafish line Tg (wt1b:EGFP) was used, and different exposure protocols were applied. Once a suitable protective concentration of BZYQD was found, antibody staining and real-time PCR methods were applied and the pro-inflammatory gene expressions were determined.
Results: The results showed that low dose (10 ppm) of BZYQD attenuates the AA-induced malformed kidney phenotype. This finding was further substantiated by an examination of the integrity of pronephric tubes in the treated embryos. Pre-treatment with BZYQD suppressed the elevated expressions of pro- inflammatory genes, including tumor necrosis factor-α and myeloperoxidase, induced by AA exposure (1.6 ~ 2.3-fold). This indicates that the nephroprotective effect of BZYQD may be mediated by suppression of pro-inflammatory gene expression. On the other hand, a high dose (500 ppm) of BZYQD caused nephrotoxic effect.
Conclusion: An efficient model to identify AA-protective compounds using zebrafish embryos has been successfully established. Using this strategy, it has been found that BZYQD is nephroprotective in zebrafish embryos, and might have the potential to be applied in humans.
Radiosensitizing effect of polysaccharide in Schisandrae chinensis (Turcz.) Baill. Fruit on ovarian cancer SKOV3 cells
Authors: Wang Cai-Xia , Wan Dan , Qiao Shi-Cong , Xia Min , Duan Ya-Ting 
Published: January 2022

Purpose: To investigate the radiosensitizing effect of polysaccharide from Schisandrae Chinensis fruit (SCFP) on ovarian cancer SKOV3 cell line.
Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate SKOV3 cell viability. Caspase-3, caspase-9, Bax, and Bcl-2 levels in SKOV3 cells were assessed by enzyme-linked immunosorbent assay (ELISA). Furthermore, mRNA expression of caspase-3, caspase-9, Bax and Bcl-2 in SKOV3 cells were determined using quantitative real-time polymerase chain reaction (RT-qPCR) assay.
Results: β-Irradiation (10 Gy) did not show obvious inhibitory effects on SKOV3 cell proliferation. However, SCFP at a dose of 1.25, 2.5 and 5 mg/mL significantly enhanced the radiosensitivity of SKOV3 cells to β-irradiation (p < 0.01). Furthermore, SCFP at concentrations of 1.25, 2.5 and 5 mg/mL significantly increased the levels of caspase-3, caspase-9 and Bax in SKOV3 cells, but decreased that of Bcl-2 (p < 0.01). In addition, SCFP combined with β-irradiation up-regulated mRNA expression of caspase-3, caspase-9 and Bax (p < 0.01), but down-regulated that of Bcl-2 in SKOV3 cells (p < 0.01).
Conclusion: SCFP significantly enhances the sensitivity of nasopharyngeal carcinoma SKOV3 cells to β-irradiation. The possible mechanism of sensitization might be correlated to the induction of mitochondria-mediated apoptosis. This research provides a scientific basis for the development of SCFP for the treatment of ovarian cancer.