bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of propofol on lung metastasis of circulating tumor cells after colorectal cancer surgery
Authors: Wu Shi , Jia Shiting , Long Houwen 
Published: February 2022

Purpose: To investigate the effect of propofol on lung metastasis of circulating tumor cells (CTCs) after colorectal cancer (CRC) surgery, and the mechanism involved.
Methods: Specific-pathogen-free (SPF) male BALB/c mice (n = 30; mean age = 7 ± 1 weeks; mean weight = 19 ± 3 g) were used for this study. To establish mouse model of CRC, 100 μL of CRC (CT26) cells was injected into the caudal vein of each mouse. Three groups of 10 mice were used: control, 5 μL/mL propofol, and 10 μL/mL propofol groups. Changes in pulmonary superficial nodules of mice lungs were determined. Colorectal cancer cell (CT26) proliferation and apoptosis were measured using Ki-67 immunohistochemical staining and in situ terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assays, respectively.
Results: The number of pulmonary nodules and proportion of proliferating cells (Ki-67 expression level) were significantly higher in 5 μL/mL propofol-treated mice, relative to control, but markedly lower in 10 μL/mL propofol group than in 5 μL/mL propofol group (p < 0.05). Although apoptotic index increased in 5 μL/mL propofol group, cell apoptosis was comparable among the groups (p > 0.05).
Conclusion: These results suggest that propofol promotes pulmonary metastasis of CTCs after CRC surgery via stimulation of CTC proliferation in the lungs. Therefore, caution should be exercised in the use of propofol in colorectal cancer surgery.
Calcium and vitamin D supplementation in pre-eclampsia: Analysis of effectiveness and safety
Authors: Gao Yanyu , Luo Dan , Wang Qiong , Lin Juan 
Published: February 2022

Purpose: To evaluate the impact of calcium and vitamin D (vit D) supplementation initiated at early pregnancy in high-risk women on reduction of preeclampsia risk.
Methods: This prospective cohort study involved 492 pregnant women who had experienced pre-eclampsia or eclampsia in their current pregnancy (high risk) and were either on calcium (1000 mg/day) as well as vit D (400 IU/day) supplementation at early pregnancy or none. All the included pregnant women received standard doses of calcium (1500 mg/day) and vit D (600 IU/day) supplementation post 20 gestation weeks till childbirth. The primary outcome was pre-eclampsia characterized by hypertension as well as proteinuria.
Results: From March 10, 2015 to February 24, 2018, each of the 246 pregnant women were assigned to the calcium/vit D group versus control group with no calcium/vit D. In the calcium/vit D group, 26.45 % developed preeclampsia compared to 32.11 % in control group with a Risk ratio [RR] of 0.82 (95 % confidence interval [CI], 0.62-1.08; p 0.167). No serious adverse events were related to calcium or vit D.
Conclusion: Calcium/vit D supplementation during early pregnancy did not demonstrate any significant reduction in pre-eclampsia. Large, high-quality studies with higher patient numbers are needed for adequate testing of impact of calcium/vit D on pre-eclampsia.
Effectiveness and safety of co-administration of moxifloxacin with netilmicin in drug-resistant tuberculosis patients, and its impact on inflammatory factors and immune function
Authors: Wang Lei , Zhang Yanping , Chen Li , Zhang Guiying , Zhu Hongzhu 
Published: February 2022

Purpose: To study the effectiveness and safety of co-administration of moxifloxacin with netilmicin in drug-resistant tuberculosis (TB) patients, and its impact on levels of inflammatory factors and immune function.
Methods: We enrolled 100 patients with drug-resistant TB admitted to People’s Hospital of Rizhao between May 2017 and October 2019. The patients were randomly allocated to control group and study group, with 50 patients per group. The control group received moxifloxacin at a dose of 0.2 g t.i.d. for 6 months and the study group received netilmicin at a dose of 0.1 g t.i.d. plus. The response, incidence of adverse reactions, expression levels of inflammatory factors, immune function, and sputum-negative status after 2, 4 and 6 months of TB treatment were compared.
Results: The study group showed markedly higher response than the control group (p < 0.05). Moreover, there were lower incidence of adverse effects in the study group than in the control group (p < 0.05). The expression levels of inflammatory factors were significantly lower in the study group, while the concentrations of CD3+, CD4+, and CD8+ were markedly higher (p < 0.05). After 2, 4 and 6 months of TB treatment, cases of sputum-negative conversion were significantly higher in the study group than in the control group (p < 0.05).
Conclusion: Co-administration of moxifloxacin with netilmicin produces much higher effectiveness and safety than moxifloxacin monotherapy, decreases inflammatory factor levels and improves immune function in patients with drug-resistant TB.
Compound Tongluo Decoction promotes generation and homing of endothelial progenitor cells after cerebral infarction in rats by activating Shh signaling
Authors: Hui Zhen , Wu Wei , Xu Chengcheng , Wang Sulei , Li Jianxiang , Zhang Jinghua , Zhang Zhennian 
Published: February 2022

Purpose: To investigate the protective effects of Compound Tongluo decoction (CTD)on neurological function in rats, and the mechanism involved in its angiogenesis-promoting effect.
Methods: Rats were arbitrarily assigned to sham group, permanent middle cerebral artery infarction (pMCAO) group, and PMCAO+CTD group (pMCAO plus 7-day oral treatment with CTD). Neurological deficit scores and volume of stroke-damaged areas were measured after 7 days of treatment. The levels of bone marrow-derived endothelial progenitor cells (BMEPCs) in serum and brain tissues were determined by flow cytometry and immunofluorescence. The expression levels of sonic hedgehog (Shh), vascular endothelial growth factor (VEGF), and angiopoietin-1(Ang-1) at infarct sites and in BMEPCs were quantitated using western blot assay.
Results: The results showed that CTD markedly ameliorated neurological deficit, reduced volume of affected areas, and promoted the production and homing of BMEPCs. Moreover, CTD upregulated Shh, VEGF and Ang-1expressions at ischemic sites and EPCs, but promoted the proliferation and metastasis of EPCs. The CTD-induced changes were significantly suppressed by Shh inhibitor cyclopamine (CP).
Conclusion: These results demonstrate that CTD promotes angiogenesis after cerebral infarction, probably by stimulating Shh signaling and triggering production and homing of EPCs, thereby providing neuroprotection against cerebral infarction. Thus, CTD is a potential neuroprotective agent against cerebral infarction in humans.
Barriers and Facilitators to eHealth Technology Use Among Community-Dwelling Individuals With Spinal Cord Injury: A Qualitative Study
Authors: Singh Gurkaran , Nimmon Laura , Sawatzky Bonita , Ben Mortenson W. 
Published: February 2022

Background
As eHealth technologies become a more prevalent means to access care and self-manage health, it is important to identify the unique facilitators and barriers to their use. Few studies have evaluated the use or potential use of eHealth technologies in spinal cord injury (SCI) populations.

Objectives
The primary objective of this study was to explore and identify barriers and facilitators to engagement with eHealth technologies among individuals with SCI.

Methods
A qualitative descriptive study was conducted. Data were collected via one-on-one, semi-structured interviews with a subsample of 20 community-dwelling participants enrolled in a larger clinical trial. Analysis of the transcripts was undertaken using a four-phase process of content analysis.

Results
Our analysis identified three barriers to engagement with eHealth technologies, including (1) overcoming a digital divide to comprehending and utilizing eHealth technologies, (2) navigating internet resources that provide too much information, and (3) interacting with these technologies despite having limited hand function. Our analysis also identified three facilitators to using eHealth technologies, including (1) having previous successful experiences with eHealth technologies, (2) being able to use voice activation features, and (3) being able to interact in an online community network.

Conclusion
By exploring barriers and facilitators to eHealth technology use, these findings may have a short-term impact on informing researchers and clinicians on important factors affecting engagement of individuals with SCI with telemedicine, mobile, and web applications (apps) and a long-term impact on informing future development of eHealth interventions and tools among chronic disease populations.
The Mori fan of the Dolgachev-Nikulin-Voisin family in genus $2$
Authors: Hulek Klaus , Liese Carsten 
Published: February 2022

In this paper we study the Mori fan of the Dolgachev-Nikulin-Voisin family in degree $2$ as well as the associated secondary fan. The main result is an enumeration of all maximal dimensional cones of the two fans.Comment: Substantially revised final version
KAJIAN SISTEM PANEN TERHADAP POTENSI CPO (CRUDE PALM OIL) DI AFDELING I KEBUN TANAH RAJA PT. BAKRIE SUMATERA PLANTATION, Tbk.
Authors: Ningsih Tuty , Gunawan Hari , Parhorasan Jhon F 
Published: February 2022

Harvest is one of determining factors to produce quality Fresh Fruit Bunches (FFB). Quality FFB is determining factors for Free Fatty Acids (FFA) and yield of the resulting oil. To produce good CPO potential, synergy is needed between the plantation part and the palm oil mill part. The research method used a descriptive method, namely to explain the harvest system and its relation to the quality of oil palm fruit. Observation data in the form of a harvest system consisting of Harvest Density Number (AKP) and random system used, Analysis of palm oil potential in the form FFB Analysis and CPO Yield. The Results showed that the harvesting system in division 1 Tanah Raja PT BSP used fixed sleigh and the potency test of palm oil showed that the CPO yield was 21.22% and FFA was 2,42%.
Kebijakan Amerika Serikat dalam Menjaga Eksistensi Pasar Global Melalui Perusahaan Coca-Cola (Kapitalisme : Coca Colonization)
Authors: Nurmamurti Resitaka Aulia , Navila Shendy Friska , Budi Ema Sulistyaning , Amanda Anggie Chyntia , Kholifah Diah Siti 
Published: February 2022

Abstrak
Perekonomian internasional tentu tidak terlepas dari perekonomian Amerika Serikat. Amerika Serikat merupakan negara dengan perekonomian terbesar di dunia. Dalam kerangka Neoliberalisme, ekonomi tidak bisa lepas dari intervensi negara. Negara dapat melakukan berbagai kebijakan dengan tujuan dapat mencapai kepentingan nasional dan keuntungan semaksimal mungkin. Tulisan ini dimaksudkan untuk memperoleh upaya Amerika Serikat membangun Coca Colonization dalam sudut pandang paradigma ekonomi kapitalisme dan neoliberalisme. Coca-Cola sendiri merupakan minuman yang berasal dari Amerika di mana sudah ada sejak tahun 1886 dan menjadi minuman bersoda nomor satu di dunia. Eksistensi Coca-Cola sendiri sudah ada pada saat masa Perang Dunia, dimana Coca-Cola ini datang bersama dengan kehadiran pasukan Amerika Serikat dan sudah ada 60 pabrik bottling Coca-Cola di seluruh dunia yang mulai dibangun pada saat ada operasi militer Amerika. Coca-Cola dianggap sebagai budaya Amerika dan menjadi duta tidak resmi gaya hidup masyarakat Amerika sendiri. Menggunakan studi kepustakaan melalui beragam berita, dokumentasi, jurnal ilmiah maka penelitian ini menghasilkan upaya Amerika Serikat meliputi membangun nation branding. Nation branding ini sangat kuat sehingga produk lokal sulit untuk lepas dari pengaruh kolonialisme produk yang ditanamkan oleh Amerika Serikat secara global.
Kata kunci: Amerika Serikat, Coca Colonization, Nation branding, Coca-Cola
Body weight perception and associated factors: a case of female adolescent’s (Morocco)
Authors: Lghoul Siham 
Published: February 2022

Background: Adolescence is associated with many physical and psychological changes, it is described as a period when body weight changes and is likely to become worrying for many adolescents.
Aim: This study aims to evaluate associations between body weight perception and body mass index (BMI) among a population of female adolescent’s.
Methods: A cross-sectional school-based study was conducted from February to May 2017 among 12–19 years olds adolescents (n = 415) from high and middle school. BMI for age percentiles was calculated using the WHO AnthroPlus. Body weight perception was determined using an anonymous questionnaire.
Results: The prevalence of body weight misconception was positively associated with the participants age (p < 0.001), the occurrence of menarche (p < 0.05), the increasing of BMI (p < 0.001), and with habits diet satisfaction (p < 0.05). Overweighed participants and who’s with normal weight were more likely to perceive their weight incorrectly (p < 0.05). Furthermore, approximately 2.9% of participants underestimated their true body weight and 57.1% overestimated their weight. However, all participants with underweight had correctly perceived their body weight.
Conclusion: It is recommended to improve healthy programs in schools aimed at preventing body weight perception and eating problems among adolescents.
Keywords: Body Weight, Perception, BMI, Female Adolescent’s, Morocco
GESTIÓN DE RIESGOS APLICADA A INVERSIONES EN INFRAESTRUCTURA. ¿APORTE ESTRATÉGICO DE LA TERCERA MISIÓN DE LAS UNIVERSIDADES?
Authors: GOMEZ SANCHEZ SOTO RUBEN 
Published: February 2022

De acuerdo con las investigaciones realizadas, se ha comprobado la existencia de una relación entre la ejecución de los proyectos de infraestructura y su desempeño como obra pública. Lamentablemente, se han registrado obras paralizadas (proyectos hospitalarios), obras con mayores costos y plazos; toda esta problemática acrecienta los problemas públicos de brecha de acceso básico a infraestructura (corto y largo plazo), reportados por el Plan Nacional de Infraestructura para la Competitividad. Y ante la pregunta, ¿Quiénes serían los más afectados por esta problemática? Lamentablemente: “Los más afectados, son los ciudadanos de a pie”. Se debe señalar la causa que genera toda esta problemática: “es la no aplicación de gestión de riesgos en la ejecución de las inversiones en proyectos de infraestructura; esta deficiencia, da como resultados proyectos no exitosos.
Otro de los aportes es la existencia de una relación directa entre la oferta de las universidades, el señalamiento de misión (primera, segunda, tercera e impacto económico), niveles y resultados de la investigación la solución de los problemas públicos, y principalmente el logro de profesionales con competencias apropiadas y necesarias para dar solución a los problemas públicos del país.
Материалы к флоре болот Тамбовской области
Authors: Гришуткин Олег Геннадьевич 
Published: February 2022

Тамбовская область находится в лесостепной природной зоне, которая характеризуется сравнительно низкой заболоченностью и сильным преобразованием естественных ландшафтов. В XX веке болота подверглись значительному антропогенному воздействию, что отразилось на флоре, но почти не было зафиксировано в публикациях последних трех десятилетий. Нами в 2011–2021 гг. маршрутно-ключевым методом обследовано 46 болот в 13 районах Тамбовской области, на основе полученных результатов составлен список высших растений, указано их распределение по основным типам болот (низинные, переходные, верховые) и встречаемость. На болотах Тамбовской области выявлено 158 видов сосудистых растений (108 родов и 55 семейств) и 33 вида мхов (14 родов и 9 семейств). Наиболее часто на болотах региона из сосудистых растений встречались Salix cinerea, Typha latifolia, Lysimachia vulgaris, L. thyrsiflora, Carex acuta, Betula pubescens, Calamagrostis canescens, Phragmites australis, Lycopus europaeus, из мхов – Sphagnum fallax, S. flexuosum, S. angustifolium. На болотах зафиксированы популяции 22 видов, включённых в Красную книгу Тамбовской области.

БлагодарностиРабота проведена в рамках выполнения государственного задания 121051100099-5.
Psychosocial Risks and Subjective Well-Being in the Canadian Workplace
Authors: Moulin Stephane 
Published: February 2022

This article puts forward a new typology of workers, based on an enhanced set of indicators of psychosocial risks and well-being, and examines the character traits associated with each class membership. This article innovates by simultaneously taking into account how hostile behaviours, poor working conditions and employment precariousness are associated with different subjective measures of well-being. This study uses a person-centered approach by conducting latent class analysis on a representative sample of 5,867 Canadian employees. Six distinct clusters are revealed: “heavily suffering”, “unfulfilled precarious”, “unhealthy stressed”, “untroubled harassed”, “optimistic precarious” and “not exposed”. This article thus shows that it is not harassment or lack of social benefits per se that affect workers’ well-being. It demonstrates that workers’ well-being deteriorates only when hostile behaviours/conflicts and poor working/employment conditions overlap. Binary logistic regression analyses reveal that, controlling for other worker characteristics, this typology of workers is related to work ethic and resilience. The results suggest two key trends: overlapping exposure to precariousness, procedural injustice and poor prospects for career advancement reduces hard work ethic, while overlapping exposure to hostile behaviour/conflicts and competition reduces resilience.
What happens when Chinese firms invest in European infrastructure
Authors: Mohan Giles 
Published: February 2022

What happens when Chinese firms invest in European infrastructure
REDEFINE will examine what China’s rise means for how we understand global development and, specifically, Europe’s place in it. REDEFINE aims to use the insights from international development to interrogate Chinese engagement in the heart of Europe and, by doing so, reorient the Eurocentric debates in the social sciences around how we define and delimit development, who drives these processes, and what it means for societies and communities affected by such investments.
Jaminan Kemurnian Al-Qur’an Surah al-Isra’ Ayat 88, Hud Ayat 13, Yunus Ayat 38 dan al-Baqarah Ayat 23 Persepektif Abu Hayyan al-Andalusi dalam kitab Al-Bahr al-Muhith Kajian Tafsir Tematik
Authors: Fauzi Taufiqurrahman 
Published: February 2022

Allah menurunkan kitab suci Al qur’an dan sampai saat ini masih terjaga kemurniannya. Tentu banyak kaum kafir untuk merusak kemurnian Al Qur’an tersebut. Namun dalam hal ini sekalipun mereka gotong royong mengajak semua manusia, laki-perempuan, kafir atau mukmin, yang memiliki keraguan pada al-Qur’an, mereka dapat dipastikan tidak akan bisa mendatangkan dan meniru al-Qur’an. Dalam hal ini penulis tertarik untuk mengkaji apa saja jaminan kemurnian Al qur’an di berbagai surah menurut persepektif Abu hayyan al- Andalusi dalam kitab Al-Bahr al-Muhith. Kajian ini menggunakan kajian Tafsir tematik. Setelah dilakukan kajian, penulis menemukan hal hal terkait macam-macam tantangan yang diberikan al-Qur’an ada empat tingkatan. Ini juga dikatakan sebagai tinggkatan mukjizad al-Qur’an. Itu pula merupakan jaminan atas kemurnia al-Qur’an.
Kata kunci: Kemurnian Al Qur’an
The Singapore Convention on Mediation and the New York Convention on Arbitration: Comparing Enforcement Mechanisms and Drawing Lessons for Asia
Authors: Chua Eunice 
Published: February 2022

This article considers the enforcement mechanism for international mediated settlement agreements proposed by the Singapore Convention on Mediation and critically examines this mode of enforcement as against enforcement as an arbitral award in Asia, including through a hybrid process like Arb-Med-Arb. Similarities and differences between the New York Convention and the Singapore Convention on Mediation will be discussed and used to consider how Asian jurisdictions may respond to the Singapore Convention on Mediation and what lessons may be learnt from the arbitration context.
Arbitration, Mediation, New York Convention, Singapore Convention on Mediation, International dispute resolution
Pelatihan UMKM Berbasis Online di Kantor Pemerintahan Desa Lambangsari Kecamatan Tambun Selatan Kabupaten Bekasi
Authors: Kumala Destiana , Hidayat Taufik 
Published: February 2022

Artikel pengabdian masyarakat ini membahas tentang proses kegiatan pelatihan UMKM berbasis online di kantor pemerintahan Desa Lambangsari. Pelaksanaan kegiatan Pelatihan UMKM Berbasis Online ini dihadiri 30 (tiga puluh) Peserta, bertempat di Kantor Pemerintahan Desa Lambangsari Kecamatan Tambun Selatan Kabupaten Bekasi. Pelaksanaan ini diadakan dengan protokol kesehatan Covid-19. Adapun tema yang di usung dalam pelatihan ini adalah “UMKM Naik Kelas”. Metode yang di gunakan dalam pelatihan ini adalah pertama Persiapan dan Sosialisasi, yaitu dengan pemberian materi oleh pembicara, kedua Pelatihan dan Pendampingan yaitu dengan di bentuknya Forum Group Discussion, dan ketiga adalah Evaluasi. Adapun hasil dari pelatihan ini adalah bahwa pengetahuan peserta pelatihan mengenai UMKM berbasis online semakin meningkat. Selain itu pemateri juga memberikan usulan yang sangat potensial untuk perkembangan Desa Lambangsari yaitu model bisnis sharing ekonomi dengan membuat marketplace, yang didalamnya akan menjual produk UMKM binaan dari Desa Lambangsari, tentunya dengan menyesuaikan kebutuhan pasar. Pembicara juga memberikan saran untuk menjalankan bisnis diatas adalah dengan membentuk inkubator bisnis, yaitu dengan urung dana dari masyarakat Desa Lambangsari serta mengedukasi, sosialisasi ke semua Pihak termasuk dengan melibatkan masyarakat, pemerintah, swasta, pengusaha dan para profesional lainnya.
KEPEMIMPINAN KEPALA DESA DALAM MEWUJUDKAN DESA YANG MAJU DAN MANDIRI ( Studi Multisitus pada Desa di Kecamatan Dringu Kabupaten Probolinggo)
Authors: Bukhari  , Ernani Hadiyati  , Sugeng Mulyono  
Published: February 2022

The village head's leadership is very influential on the progress of the village. Good village governance and quality village officials are able to bring villages to become independent in improving the welfare of village communities. Qualitative research with a multi-site method is needed to obtain in-depth information about the style and strategy, triggers and inhibiting factors, as well as the expectations of the leadership of the village head in the Dringu Subdistrict, Probolinggo Regency. A qualitative method with a multi-site approach was used in this study. This design was carried out guided by 3 stages of phenomenology, namely the intuitive stage, bracketing, analyzing and doing descriptive and interpretation. Unstructured interviews are used as the main method of data collection. There are 10 participants who have been saturated and based on participant criteria. The results of the study found 3 themes, namely (1) Leadership of innovative progressive and visioner village heads; (2) The duties and responsibilities of the village head are full time; (3) Hope to be an independent and participatory village.
Keywords: Leadership, Village Head, developed and independent villages.