bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial and temporal cooccurrence among Neotropical native coccinellids and the exotic Harmonia axyridis
Authors: Rizzo María Estefanía , Salvo Adriana , Rocca Margarita , Greco Nancy 
Published: November 2022

Abstract

Coccinellids are important biological control agent and aphid predators in horticultural crops around the world. Neotropical Cycloneda sanguinea, Eriopis connexa and Coleomegilla quadrifasciata octodecimpustulata, and the exotic Harmonia axyridis (all Coleoptera: Coccinellidae), are predators that mainly feeds on aphids. In this work we described the abundance of these coccinellid species and their spatial and temporal cooccurrence in agroecological eggplant crop of Argentina. We also estimate the intensity and symmetry of the intraguild predation between C. quadrifasciata octodecimpustulata and the other species in laboratory experiments. Both temporal and spatial segregation was observed, and H. axyridis was the strongest intraguild predator in the interaction with C. quadrifasciata octodecimpustulata, and this latter was the strongest intraguild predator in interaction with C. sanguinea and E. connexa. In this context, native coccinellid species would be vulnerable to the exotic and invasive H. axyridis; however, the lack of cooccurrence of this species with the native ones, under conditions of low density of extra-guild prey would indicate that spatial segregation could be the mechanism by which these species coexist in the eggplant crop.
Nomogram for predicting preoperative axillary lymph node status in male breast carcinoma: SEER population-based study
Authors: Chen Wenxin , Wang Hebing , Yang Binglin , Zhang Maoquan , Chen Jicheng 
Published: November 2022

Abstract
Background
Sentinel lymph node (SLN) has been recommended as a replacement for axillary lymph node dissection (ALND) in male breast carcinoma (MBC) with clinical axillary lymph node-negative as in women. However, the morbidity after SLN may also have short-term or long-term complications. It is imperative to develop a model to evaluate the risk of lymph node metastasis to avoid unnecessary operations.
Patients and Methods
: A retrospective review of the clinical and pathology records were performed in patients diagnosed with MBC between 2010 and 2018 from Surveillance, Epidemiology, and End Results (SEER) database. The cohort was divided into training and validation cohorts. A logistic regression model was used to construct the nomogram in the training cohort and then verified in the validation cohort.ROC curve, C-index, and calibration were used to assess the predictive ability of the nomogram.
Results
Overall, 2,610 patients diagnosed with MBC were enrolled, of which 1,740 were in the training cohort and 870 were in the validation cohort. Logistic regression analysis indicated ,age at diagnosis, tumor location, tumor stage, pathological type, and histologic grade were significantly related to axillary lymph node metastasis(ALNM). The AUC of the nomogram was 0.846 (95% CI, 0.825–0.867) and C-index was 0.848 (95%CI, 0.807–0.889), demonstrating a good prediction performance. The calibration curve for the nomogram was plotted and the slope was close to 1. The performance of the nomogram was further validated in the validation cohort, with an AUC of 0.848 (95% CI 0.819–0.877).
Conclusion
We successfully established a nomogram to predict LANM, especially for those who were of advanced age at diagnosis,had small tumor size, low malignancy, and clinical axillary lymph node-negative to avoid unnecessary axillary operation —thus improving the quality of life of the patients without adverse effect on their survival rates.
Development of TPMS inspired thin walled structured metal foams from unsorted ferrous scrap through melt route
Authors: Chandrakanth Balaji , Prakash Ved , Maiti Adwaita , Rajak Anup , Mukherjee Diya 
Published: November 2022

Abstract
Porous castings are avant-garde materials termed as cellular metals. It showcases attractive characteristics likened to their solid equivalents. Powder metallurgy has been long utilized to manufacture cellular metals using diverse chemicals to attain internal pores, however this method is not viable for hefty components. The proposed methodology in this investigation is capable to produce structured foam using space holders using melt route. Melting and casting of cast iron foam described in this work to develop foam structure inspired by TPMS cellular structure (Schwarz, Modified Schwarz and I-WP). Porosity of 62.4% is achieved through casting route against numerically predicted 65% with a compressive strength of 177.4 MPa. Radiography tests shows that there are no significant defects in the connectivity region and there is full connectivity between pores that is in line with the results attained from pre-cast simulations. Optical projection of the casted sample is done as a confirmatory test for ensuring connectivity. Thickness of as low as 1.5mm is casted with Cast Iron in a structured manner.
Investigating asymmetric impacts of total factor energy efficiency on carbon emissions in India
Authors: Mahapatra Bamadev , Irfan Mohd 
Published: November 2022

Abstract
As many complex energy relations are not linear and have diminishing returns, assuming a symmetric (linear) effect of energy efficiency (ENEF) on carbon emissions (CAE) has limited our understanding of the emission-ENEF nexus. This study, therefore, estimates total factor energy efficiency by employing a stochastic frontier approach and analyses the asymmetric (nonlinear) long and short-run effects of ENEF on CAE, using sample panels for India covering the period 2000 to 2014. The asymmetric impacts are examined by utilising a nonlinear panel autoregressive distributed lag modelling framework. The findings evidenced the existence of asymmetric short-run and long-run effects of ENEF on CAE for India. Based on the outcomes, numerous crucial implications are discussed with a particular reference to developing economies like India.
Phytoremediation potential of sweet flag (Acorus calamus L.), an emergent macrophyte, to remove inorganic arsenic from water
Authors: Li Shuhui , Liu Guangyi , Zhang Ting 
Published: November 2022

Abstract
In this study, the emergent macrophyte sweet flag (Acorus calamus L.) was used to remove different concentrations (200, 500, and 1,000 µg L‒1) of arsenate [As(V)] and arsenite [As(III)] from water. The removal efficiencies of As(V) and As(III) reached more than 95%. As(III) could be removed by A. calamus L. more efficiently than As(V). In both As(V)- and As(III)-exposed A. calamus L., the arsenic contents were much higher in the root than in the stem and leaf. The translocation factors of As(V) and As(III) were no more than 0.152. Both As(V) and As(III) were found in the whole plant, whereas dimethylarsinic acid (DMA, 0.06‒0.13 mg kg‒1) was only present in the aboveground part (leaf). As(V) was the main species in the As(V)-exposed plants (45.86%‒70.21%). As(III) was the main species in the stem and leaf of As(III)-exposed plants (55.76%‒85.52%), while As(V) was still dominant in the root. A. calamus L. could keep its green leaves during the 31 days of inorganic arsenic (iAs) exposure. However, As(V) had a little inhibitory effect on height growth, and As(III) could slightly inhibit the weight gain. The concentrations of malondialdehyde (MDA) and hydrogen peroxide (H2O2), as well as the activity of catalase (CAT) were significantly higher in the root than those in the stem and leaf. The oxidative stress response of A. calamus L. to As(III) was more than that to As(V). Our findings indicated that A. calamus L. was regarded as a promising material for the removal of iAs.
Micro Slit Fabrication Using Magnetic-Assisted-ECDM and Parametric Optimization by Metaheuristic Algorithms
Authors: Gehlot Dilip , Jha PRADEEP Kumar , Jain Pramod Kumar 
Published: November 2022

Abstract
Micro-slit fabrication of more than 1000 microns thick workpieces using the ECDM process is a complicated task since the ejection efficiency to remove the adhered particle dissolved from the workpiece in the electrolyte decreases with a higher depth of cut. Here micro-slit fabrication of more than 1200 µm thickness was carried out with magnetic field application on the ECDM. The magnetic field induces MHD convection on the electrolyte flow around the tool, which creates vorticity on the electrolyte. The centrifugal force created by the fluid when it rotates under MHD convection removes the material at a higher depth of cut. The machining performance in terms of maximum slit-cut thickness improves with increasing the magnetic field strength up to the optimum level because it induces the centrifugal force on the bubble, which enhances the gas film formation and discharge frequency. The experiments were conducted to fabricate a micro-slit with Taguchi L18 design and observe the effect of voltage, concentration, magnetic strength, and feed rate on MRR and width overcut. The magnetic field contributes significantly to the machining rate and overcut improvements. The metaheuristic algorithms, i.e., particle swarm optimization, differential evolution, and TLBO, applied and compared the optimal results of response parameters. The results reveal that the optimum value of MRR and WOC are the same, but the time and the iterations necessary to reach the optimal solution differ.
Extreme poverty, economic growth and income inequality trilogy in sub-Saharan Africa and South Asia: A GMM panel VAR approach
Authors: Labidi Mohamed Ali , Ochi Anis , Saidi Yosra 
Published: November 2022

Abstract

This study allows the assessment the triangular relationship between extreme poverty, economic growth and income inequality in South Asia and sub-Saharan Africa. Unlike previous studies in the poverty-inequality-growth literature, this study employed the panel vector autoregressive model to examine the impact of income inequality and economic growth on extreme poverty. Moreover, we used the impulse response function tool, which was developed in the same context, to better understand the reaction of the two main variables of interest, extreme poverty and economic growth, aftershocks on income inequality variable. Finally, the analysis was completed by the variance decomposition of all variables. These analyses were conducted for a 56 South Asian and sub-Saharan African countries from 1990 to 2020. Overall, the results show that income inequality has a positive and significant impact and can strongly explain economic growth. Meanwhile, the results indicate a negative and significant relationship between economic growth and extreme poverty. Our empirical result reveals that there is no relationship between income inequality and extreme poverty.JEL Classification codes: I32, F43, D3, C33, O55, O53
Description of the nationally implemented National Health Service Digital Diabetes Prevention Programme intervention and rationale for its development: mixed methods study
Authors: Miles Lisa M , Hawkes Rhiannon E , French David P 
Published: November 2022

Abstract
Background
The National Health Service (NHS) Digital Diabetes Prevention Programme (DDPP) is a behaviour change programme for adults in England who are at high risk of developing type 2 diabetes. Four independent providers deliver the NHS-DDPP following a competitive tendering process. Although providers work to a single service specification, there is potential for some variation in the service across providers. This study 1) assesses fidelity of the structural features of the design of the NHS-DDPP compared to the service specification, 2) describes the structural features of delivery of the NHS-DDPP as implemented 3) reports developers’ views on how the structural components of the NHS-DDPP were developed and why changes were made following implementation.
Methods
Using mixed methods, we conducted a document review of providers’ NHS-DDPP design and delivery documentation, and extracted information using the Template for Intervention Description and Replication checklist, which was adapted to capture features of digital delivery. Documentation was supplemented by content analysis of interviews with 12 health coaches involved in delivering the NHS-DDPP. Semi-structured interviews were also conducted with 6 programme developers employed by the digital providers.
Results
Provider plans for the NHS-DDPP show relatively high fidelity to the NHS service specification. Despite this, there was wide variation in structural features of delivery of the NHS-DDPP across providers, particularly for delivery of ‘support’ (e.g. use, dose and scheduling of health coaching and/or group support). Interviews with developers of the programmes showed that much of this variation is likely to be attributable to the origin of each provider’s programme, which was usually a pre-existing programme that was adapted to conform to the NHS-DDPP service specification. The NHS-DDPP is continually improved and developed based on user experience feedback and research conducted by the providers.
Conclusions
Indirect evidence suggests that variation in delivery of support could affect effectiveness of the NHS-DDPP. A priority for future research is ascertaining whether the variation in delivery of the NHS-DDPP across providers is related to any differences in health outcomes. It is recommended that future rounds of commissioning the NHS-DDPP pre-specify the type of support participants should receive, including expected dose and scheduling.
Partitioning of Diluted Anyons Reveals their Braiding Statistics
Authors: Heiblum Moty , Sim Heung-Sun , Oreg Yuval , Hong Changki , Lee June-Young , Alkalay Tomer , Schiller Noam , Umansky Vladimir 
Published: November 2022

Abstract
Correlations of partitioned particles carry essential information about their quantumness [1]. Partitioning full beams of charged particles leads to current fluctuations, with their autocorrelation (AC, shot noise) revealing the particles’ charge [2]. This is not the case when the partitioned particle beams are diluted. Bosons or fermions will exhibit particles antibunching (due to their discreteness) [3, 4]. However, when partitioning anyons, such as the quasiparticles in fractional quantum Hall states (FQH), the AC unveils an essential aspect of their exchange statistics: their ‘braiding phase’ [5]. Here, we describe detailed measurements of partitioning diluted anyonic edge modes of the FQH 1/3-state. The measured excess AC agrees with our theory of braiding in the ‘time-domain’ - with a braiding angle of 2θ=2π/3 - without any fitting parameters. Our work offers a relatively straightforward and simple method to observe the braiding statistics of other exotic states, such as non-abelian states, without resorting to complex interference experiments [6].
RPL22L1, a Novel Candidate Oncogene Promotes Temozolomide Resistance by Activating STAT3 in Glioblastoma
Authors: Chen Yunping , Guan Qing , Li Chenlong , Zhang Yangong , Xu Yinzhi , Zhou Chong , Guo Ying , Ma Yanan , Mu Yu , Zhao Meiqi , Ji Guohua , Liu Peng , Sun Donglin , Sun Haiming , Jin Yan , Wu Nan 
Published: November 2022

Abstract
Aggressiveness and drug resistant are major challenges in the clinical treatment of glioblastoma (GBM). Our previously research reported a novel candidate oncogene ribosomal protein L22 like 1 (RPL22L1). The aim of this study was to elucidate the potential role and mechanism of RPL22L1 in progression and temozolomide (TMZ) resistance of GBM. Online database, tissue microarrays and clinical tissue specimens were used to evaluate the expression and clinical implication of RPL22L1 in GBM. We performed cell function assays, orthotopic and subcutaneous xenograft tumor models to evaluate the effects and molecular mechanisms of RPL22L1 on GBM. RPL22L1 expression was significantly upregulated in GBM and associated with poorer prognosis. RPL22L1 overexpression enhanced GBM cell proliferation, migration, invasion, TMZ resistance and tumorigenicity, which could be reduced by RPL22L1 knockdown. Further, we found RPL22L1 promoted mesenchymal phenotype of GBM and the impact of these effects was closely related to EGFR/STAT3 pathway. Importantly, we observed that STAT3 specific inhibitor (Stattic) significantly inhibited the malignant functions of RPL22L1, especially on TMZ resistance. RPL22L1 overexpressed increased combination drug sensitive of Stattic and TMZ both in vitro and in vivo. Moreover, Stattic effectively restored the sensitive of RPL22L1 induced TMZ-resistant in vitro and in vivo. Our study identified a novel candidate oncogene RPL22L1 which promoted the GBM malignancy through STAT3 pathway. And we highlighted that Stattic combined with TMZ therapy might be an effective treatment strategy in RPL22L1 high-expressed GBM patients.
Post-discharge light physical activity indicates recovery in acutely hospitalized older adults – the Hospital-ADL study
Authors: Terbraak Michel , Kolk Daisy , Vroomen Janet L. MacNeil , Twisk Jos W.R. , Buurman Bianca M. , Schaaf Marike 
Published: November 2022

Abstract
Background: Physical activity (PA) levels might be a simple overall physical marker of recovery in acutely hospitalized older adults; however cut-off values post discharge are lacking. Our objective was to identify cut-off values for post-discharge PA that indicate recovery among acutely hospitalized older adults and stratified for frailty.
Methods: We performed a prospective observational cohort study including acutely hospitalized older adults (≥70 years). Frailty was assessed using Fried’s criteria. PA was assessed using Fitbit up to one week post discharge and quantified in steps and minutes light, moderate or higher intensity. The primary outcome was recovery at 3-months post discharge. ROC-curve analyses were used to determine cut-off values, and logistic regression analyses to calculate odds ratios (ORs).
Results: The analytic sample included 174 participants with a mean (standard deviation) age of 79.2 (6.7) years of whom 84/174 (48%) were frail. At 3-months, 109/174 participants (63%) had recovered of whom 48 were frail. In all participants, determined cut-off values were 1369 steps/day (OR: 2.5, 95% confidence interval [CI]: 1.3–4.6) and 76 minutes/day of light intensity PA (OR: 3.0, 95% CI: 1.6–5.8). In frail participants, cut-off values were 1043 steps/day (OR: 3.3, 95% CI: 1.3–8.4) and 72 minutes/day of light intensity PA (OR: 4.2, 95% CI: 1.6–10.8). Determined cut-off values were not significantly associated with recovery in non-frail participants.
Conclusions:
Post-discharge PA cut-offs indicate the odds of recovery in older adults, especially in frail individuals, however are not equipped for use as a diagnostic test in daily practice. This is a first step in providing a direction for setting rehabilitation goals in older adults after hospitalization.
Water-land-food nexus for sustainable agricultural development in main grain-producing areas of North China Plain
Authors: Zhu Lijia , Bai Yuping , Zhang Lijin , Wu Genan , Si Wanyi , Wang Anni 
Published: November 2022

Abstract
Stable and sustainable food production is an important guarantee for national security, economic development, and social stability. Water and land resources are key elements of grain production. Moreover, their unbalanced distribution will threaten sustainable agricultural development and regional food security. The main grain-producing areas in North China are important grain production bases in China, and it is vital to investigate the water-land-food nexus in order to promote sustainable regional grain production and sustainable use of land and water resources. Therefore, this study adopts the Gini coefficient and the water-land matching coefficient for exploring the water-land nexus in the main grain-producing areas of North China from 2000 to 2020. The water-land-food nexus considering grain crop production structure is further explored from spatial and temporal multi-scales. The results show that: (1) the Gini coefficient presents an increasing trend in the main grain-producing areas in North China from 2000 to 2020, indicating an increasing imbalance of the matching degree of agricultural water and land resources among inter-regions, with the most balance in Jiangsu Province, whereas the most imbalance in Anhui Province. (2) There are significant differences in WL nexus and WLF nexus among regions, showing a spatial pattern of "worse in the north and better in the south". Regarding on the WLF nexus, 60.8% of the municipalities are mismatched or mildly mismatched. (3) The cities such as Hengshui, Cangzhou and Suzhou belonged to the low WL-low WLF and high WL-low WLF should be considered as key targets when formulating policies. Adjusting the wheat-maize biannual system, optimizing the grain cultivation structure adapting to water resources distribution, promoting semi-dryland farming, reducing the intensity of irrigation water use and developing low water-consuming and high-yielding crop varieties are important for these regions. (4) In addition, improving field water-saving irrigation facilities, utilizing transit surface water resources reasonably and adhering to water conservation and water use target control are also essential measures for agricultural water management in North China Plain.
Performance of four centralized statistical monitoring methods for early detection of an atypical center in a multicenter study
Authors: Niangoran Serge , Journot Valérie , Marcy Olivier , Anglaret Xavier , Alioum Ahmadou 
Published: November 2022

Abstract
Background
The quality of the data collected is essential for the credibility of the results of clinical trials. Centralized statistical monitoring (CSM) has been proposed to quickly identify one study center in which the distribution of a variable is atypical, prompting on-site confirmation of the problem and correction as necessary. The ideal CSM method should allow early detection of a problem and therefore involve the fewest possible participants.
Methods
We simulated clinical trials and compared the performance of four CSM methods (Student, Desmet, Hatayama, Distance) to detect whether the distribution of a quantitative variable was atypical in one center in relation to the others, with different numbers of participants and different mean deviation amplitudes.
Results
The Desmet and Distance methods had low sensitivity for low mean-deviation values but very high specificity for detecting all deviations of the mean (including small values). The Student and Hatayama methods had higher sensitivity for low mean-deviation values but very low specificity for detecting all deviations of the mean. Increasing the number of participants in the atypical center, or increasing the ratio of the number of participants in the atypical center to the number of participants in the study, did not fundamentally alter the findings.
Conclusion
Although the Student and Hatayama methods are more sensitive, their low specificity would lead to too many alerts being triggered, which would result in additional unnecessary control work to ensure data quality. The Desmet and Distance methods have low sensitivity when the deviation from the mean is low, suggesting that the CSM should be used alongside other conventional monitoring procedures rather than replacing them. However, they have excellent specificity, which suggests they can be applied routinely, since using them takes up no time at central level and does not cause any unnecessary workload in investigating centers.