bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast joint estimation for time delay and angle of arrival based on smooth preprocessing with orthogonal frequency division multiplexing
Authors: Du Jinzhi , Cui Weijia , Ba Bin , Jian Chunxiao , Li Hao 
Published: July 2022

AbstractIn order to solve the problems of high complexity and absence of adaptability with the joint estimation for time delay (TD) and angle of arrival (AOA) in coherent multipath environments, a fast estimation algorithm based on orthogonal frequency division multiplexing (OFDM) technique is proposed. First, we combine OFDM signal characteristics with array features to obtain extended arrays. Then, we obtain the channel frequency domain response covariance matrices for TD and AOA estimation separately by smoothing preprocessing in the spatial and frequency domains, respectively. Finally, we estimate the TD values by a one‐dimensional (1‐D) spectral peak search, as well as determine the closed‐form solution for AOA by Unitary‐ESPRIT. In comparison with previous work, the proposed algorithm not only improves the adaptability in correlated or mixed multipath environments but also significantly reduces the complexity. The simulation results show the effectiveness and robustness of the proposed joint estimation algorithm.
TC-325 hemostatic powder in the management of upper gastrointestinal malignant bleeding: a randomized controlled trial
Authors: Martins Bruno Costa , Abnader Machado Andressa , Scomparin Rodrigo Corsato , Paulo Gustavo Andrade , Safatle-Ribeiro Adriana , Naschold Geiger Sebastian , Lenz Luciano , Lima Marcelo Simas , Pennacchi Caterina , Ribeiro Ulysses , Barkun Alan N. , Maluf-Filho Fauze 
Published: July 2022

Abstract
Background and study aims Upper gastrointestinal bleeding (UGIB) from malignancy is associated with high rebleeding and mortality rates. Recently, TC-325 powder has shown promising results in the treatment of UGIB, including malignant bleeding. The aim of this study was to compare the efficacy of TC-325 versus best clinical management.
Patients and methods From August 2016 to February 2020, all patients with evidence of UGIB from malignancy were randomized to receive TC-325 therapy or control group, in which endoscopic treatment was not mandatory. Exclusion criteria were hemoglobin drop without overt bleeding and UGIB from non-tumor origin. The primary outcome was 30-day mortality. Secondary outcomes were 30-day rebleeding, blood transfusion and length of hospital stay.
Results Sixty-two patients were randomized, three were excluded and 59 were included in the final analysis (TC-325 group = 28; control = 31). Groups were similar at baseline. Active bleeding was observed in 22 patients in the TC-325 group and 19 in the control group (P = 0.15). Successful initial hemostasis with TC-325 was achieved in all cases. Additional therapy (radiotherapy, surgery or arterial embolization) was equally performed in both groups (42.9 % vs 58.1 %; P = 0.243). There were no differences in 30-day mortality (28.6 % vs. 19.4 %, P = 0.406) or 30-day rebleeding rates (32.1 % vs. 19.4 %, P = 0.26). Logistic regression identified no significant predictors of rebleeding. Age, Eastern Cooperative Oncology Group (ECOG) score 3 to 4 and AIMS65 score > 1 predicted greater mortality.
Conclusions TC-325 was effective in achieving immediate hemostasis in malignant gastrointestinal bleeding but did not reduce 30-day mortality, 30-day rebleeding, blood transfusion or length of hospital stay. Age, ECOG 3–4, and AIMS65 > 1 were predictive factors of mortality.
Risk of residual neoplasia after a noncurative colorectal endoscopic submucosal dissection for malignant lesions: a multinational study
Authors: Santos-Antunes João , Pioche Mathieu , Ramos-Zabala Felipe , Cecinato Paolo , Gallego Rojo Francisco J. , Barreiro Pedro , Félix Catarina , Sferrazza Sandro , Berr Frieder , Wagner Andrej , Lemmers Arnaud , Figueiredo Ferreira Mariana , Albéniz Eduardo , Uchima Hugo , Küttner-Magalhães Ricardo , Fernandes Carlos , Morais Rui , Gupta Sunil , Martinho-Dias Daniel , Rios Elisabete , Faria-Ramos Isabel , Marques Margarida , Bourke Michael J. , Macedo Guilherme 
Published: July 2022

Background Endoscopic submucosal dissection (ESD) in colorectal lesions is technically demanding and a significant rate of noncurative procedures is expected. We aimed to assess the rate of residual lesions after a noncurative ESD for colorectal cancer (CRC) and to establish predictive scores to be applied in the clinical setting.
Methods Retrospective multicenter analysis of consecutive colorectal ESDs. Patients with noncurative ESDs performed for the treatment of CRC lesions submitted to complementary surgery or with at least one follow-up endoscopy were included.
Results From 2255 colorectal ESDs, 381 (17 %) were noncurative, and 135 of these were performed in CRC lesions. A residual lesion was observed in 24 patients (18 %). Surgery was performed in 96 patients and 76 (79 %) had no residual lesion in the colorectal wall or in the lymph nodes. The residual lesion rate for sm1 cancers was 0 %, and for > sm1 cancers was also 0 % if no other risk factors were present. Independent risk factors for lymph node metastasis were poor differentiation and lymphatic permeation (NC-Lymph score). Risk factors for the presence of a residual lesion in the wall were piecemeal resection, poor differentiation, and positive/indeterminate vertical margin (NC-Wall score).
Conclusions Lymphatic permeation or poor differentiation warrant surgery owing to their high risk of lymph node metastasis, mainly in > sm1 cancers. In the remaining cases, en bloc and R0 resections resulted in a low risk of residual lesions in the wall. Our scores can be a useful tool for the management of patients who undergo noncurative colorectal ESDs.
Association of Prostaglandin Use for Cervical Ripening with Mode of Delivery in Small for Gestational Age versus Non–Small for Gestational Age Neonates
Authors: Bridges Alexis G. , Allshouse Amanda A. , Canfield Dana R. , Grover Bryan W. , Son Shannon L. , Einerson Brett D. , Silver Robert M. , Haas David M. , Grobman William A. , Simhan Hyagriv N. , Day Robert C. , Blue Nathan R. 
Published: July 2022

Objective Prostaglandins (PGs) use for cervical ripening with small for gestational age (SGA) fetuses is controversial since it remains uncertain if use increases the chance of cesarean delivery (CD). We aimed to assess the association between PG use for cervical ripening and mode of delivery between SGA and appropriate for gestational age (AGA) neonates.
Study Design Secondary analysis of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), a prospective observational cohort study of 10,038 nulliparas. We included women undergoing induction with nonanomalous fetuses in the cephalic presentation. Women with >2 cm cervical dilation or prior uterine scar were excluded. We assessed the association of PG use with CD among women with SGA and AGA neonates. SGA was defined as birth weight <10th percentile for gestational age and sex. Multivariable logistic regression was used to adjust for potential confounders and test for interaction. Secondary outcomes included adverse neonatal outcomes, indication for CD, maternal hemorrhage, and chorioamnionitis.
Results Among 2,353 women eligible, PGs were used in 54.8%, SGA occurred in 15.1%, and 35.0% had CD. The association between PG use and CD differed significantly (interaction p = 0.018) for SGA versus AGA neonates; CD occurred more often in SGA neonates exposed to PGs than not (35 vs. 22%, p = 0.009). PG use was not associated with CD among AGA neonates (36 vs. 36%, p = 0.8). This effect remained significant when adjusting for body mass index, race/ethnicity, and cervical dilation. Among SGA neonates, CD for “nonreassuring fetal status” was similar between PG groups. Among SGA neonates, PG use was not associated with adverse neonatal outcomes or postpartum hemorrhage but had a higher rate of chorioamnionitis (7.0 vs. 2.1%, p = 0.048).
Conclusion PG use was associated with a higher rate of CD in SGA but not AGA neonates; however, further studies are needed before PG use is discouraged with SGA neonates.
Key Points
Reduction in SARS-CoV-2 Oral Viral Load with Prophylactic Mouth Rinse
Authors: Ghasemi Shohreh , Nadji Seyed Alireza , Heidari Ali , James Jeffrey N. , Karimi-Galougahi Mahboobeh , Raygani Negar , Khazaei Salman , Mehri Freshteh , Poormohammadi Ali , Bashirian Saeid , Mehrpooya Maryam , Miresmaeili Amirfarhang , Jalilian Farid Azizi , Shirahmadi Samaneh , Keramat Fariba , Soltanian Alireza , Ansari Nastaran , Zeynalzadeh Farhad , Ebrahimi Amirali , Dashti Amirreza , Bloomquist Ryan F. , Dashti Mahmood 
Published: July 2022

Abstract
Objectives The medical and health facilities are at high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study tested the preprocedural prophylactic mouthwash rinses to reduce the oral viral load. The findings from this study will help the practitioners to select the best mouthwash for the patients to mitigate the risk of transmission during aerosolizing. This study aimed to evaluate the effectiveness of four commonly used types of mouthwash in reducing intraoral viral load among hospitalized coronavirus disease 2019 patients.
Materials and Methods This prospective cohort study was conducted with 116 patients referred to the Masih Daneshvari Hospital in Tehran, Hamadan University of Medical Sciences of Hamadan City, and Mashhad University of Medical Sciences. Patients were randomized into four groups with each group rinsed their mouth with 20 mL of 2% povidone-iodine, 1% hydrogen peroxide, normal saline as a control study group, or 0.12% chlorhexidine, respectively, for 20 seconds. The standard reverse transcription polymerase chain reaction method evaluated the virus load before and at 1 hour, 2 hours, and 4 hours after using the mentioned mouthwash.
Results Our results revealed that chlorhexidine and H2O2 showed the highest efficiency in reducing SARS-Co-2 load in the oral cavity and nasopharyngeal region of patients; they increased the Ct values by 9 to 10 (before: 25.84 vs. after 32. 4, p < 0.455) (17.333 vs. after 26.497, p <0.097).
Conclusion Our findings suggest that chlorhexidine and H2O2 could be used in dental clinics to reduce the risk of transmitting the SARS-CoV-2 virus from infected individuals to dentists before dental procedures.
A New 12q21 Deletion Syndrome: A Case Report and Literature Review
Authors: Di Nora Alessandra , De Costa Greta , Di Mari Alessia , Montemagno Marco , Pavone Vito , Pavone Piero 
Published: July 2022

AbstractDiagnosis in children with physical and intellective anomalies is very challenging because of the wide spectrum of causes. Array-based comparative genomic hybridization (CGH) has acquired an important role in pediatric diagnostic work up. Interstitial deletion of the long arm of chromosome 12 are rare. To date, deletions including the 12q21 region were reported in only 13 patients. The main features are development delay, eyes and central nervous system anomalies, and heart and kidney defects. We describe a 3-year-old boy with a de novo 15 Mb deletion at 12q21.1q21.32, never reported in the last cases. By screening the critical region and reviewing the literature, we identified SYT1, PPP1R12A, and CEP290 such as pathogenetic genes.
Patient-Completed Caprini Risk Score for Venous Thromboembolism Risk Assessment: Developed and Validated from 1,017 Medical and Surgical Patients
Authors: Zhang Zhu , Wu Yifan , Liu Qingxia , Dong Fen , Pang Wenyi , Zhe Kaiyuan , Wan Jun , Xie Wanmu , Wang Wei , Yang Peiran , Sun Aihua , Zhai Zhenguo 
Published: July 2022

AbstractBackground The Caprini Risk Score (CRS) is one of the most widely used risk assessment models for venous thromboembolism (VTE). A well-validated patient-completed CRS form may allow patients to self-report and simplify the evaluation by health care workers.Methods The Chinese version of the CRS was optimized for easy understanding in a pilot study. The amended CRS form was completed by prospectively recruited patients and blinded nurses. The agreement levels of the individual questions and the total scores of patient and nurse-completed forms were compared using the Kappa value. The total scores were used for risk stratification of patients. Correlation and differences between patient and nurse-completed forms were analyzed using the Spearman correlation and Bland–Altman method, respectively.Results We recruited 504 medical patients and 513 surgical patients, aged 52.7 ± 16.3 years, of which 443 (43.6%) were men, and 91.6% of the patients were educated beyond junior high school. The patients spent less time to complete the form compared with trained nurses. There was good question-to-question agreement between patient and nurse-completed CRS (k >0.6 for most questions, p < 0.0001). The total scores also showed good agreement (k = 0.6097, p < 0.0001), and enabled the classification of patients into different risk groups. The patient and nurse-derived scores were highly correlated (Spearman's r = 0.84), and without extreme values (p < 0.0001).Conclusion We have created and verified a Chinese version of the patient-completed CRS, which showed good agreement and correlation with nurse-completed CRS. CRS represents a suitable tool for VTE risk assessment of hospitalized patients in China.
Push-out Evaluation on Metal and Fiber Posts Using Two Different Types of Cement in a Hyper-Narrow Environment
Authors: Shafigh Elanz , Fekrazad Reza , Bahrani Mohammad Mehdi 
Published: July 2022

Abstract
Objective Some teeth will be damaged due to caries, trauma, or previous improvement; posts are used to repair them. Underwater divers suffer from barodontalgia as a result of the tremendous amount of pressure they feel when diving. Meanwhile, barodontalgia instances involve teeth with defective restorations. Therefore, this study aimed to determine the push-out bond strength on metal and fiber posts using two different types of cement in a hyper-narrow environment.
Materials and methods In this study, 96 single-rooted teeth, including central and lateral maxillary teeth and mandibular premolars were provided and underwent endodontic treatment. Root canal treatment, including cleaning the root canal using the manual and rotary files was performed in f2 size with 6% tipper. For purification, washing was performed in two steps with 5.25% sodium hypochlorite and normal saline, respectively. The obtained data were evaluated using statistical methods such as one-way analysis of variance and the Levene and Tamhane additional tests.
Results The quantity of push-out strength was dramatically reduced in the metal posts and fibers groups due to increasing ambient pressure. The highest decrease rate was observed in the group of metal posts and resin cement. The highest bond strength in a typical environment was related to fiber posts, and among the fiber groups, those that had the highest bond strength were used as a combination of resin cement and fiber posts.
Conclusion The highest level of bond strength among the study groups, at standard pressure and in a hyper-narrow environment, was related to fiber posts and resin cement. Therefore, the best choice for treatments for divers in a hyper-narrow climate is a combination of fiber posts and resin cement.
Expanding Access to Microneurosurgery in Low-Resource Settings: Feasibility of a Low-Cost Exoscope in Transforaminal Lumbar Interbody Fusion
Authors: Ramirez Manuel De Jesus Encarnacion , Peralta Ismael , Nurmukhametov Renat , Castillo Rossi Evelyn Barrientos , Castro Juan Sebastian , Volovich Alexander , Dosanov Medet , Efe Ibrahim E. 
Published: July 2022

Abstract
Objectives Less than a quarter of the world population has access to microneurosurgical care within a range of 2 hours. We introduce a simplified exoscopic visualization system to achieve optical magnification, illumination, and video recording in low-resource settings.
Materials and Methods We purchased a 48 megapixels industrial microscope camera with a heavy-duty support arm, a wide field c-mount lens, and an LED ring light at a total cost of US$ 125. Sixteen patients with lumbar degenerative disk disease were divided into an exoscope group and a conventional microscope group. In each group we performed four open and four minimally invasive transforaminal lumbar interbody fusion procedures. We further conducted a questionnaire-based assessment of the user experience.
Results The overall user experience was positive. The exoscope achieved similar postoperative improvement with comparable blood loss and operating time as the conventional microscope. It provided a similar image quality, magnification and illumination. Yet, the lack of stereoscopic perception and the cumbersome adjustability of the camera position and angle resulted in a shallow learning curve. Most users strongly agreed that the exoscope would significantly improve surgical teaching. Over 75% reported they would recommend the exoscope to colleagues and all users saw its great potential for low-resource environments.
Conclusion Our low-budget exoscope is technically non-inferior to the conventional binocular microscope and purchasable at a significantly lower price. It may thus help expand access to neurosurgical care and training worldwide.
ASXL3 De Novo Variant-Related Neurodevelopmental Disorder Presenting as Dystonic Cerebral Palsy
Authors: Švantnerová Jana , Minár Michal , Radová Silvia , Kolníková Miriam , Vlkovič Peter , Zech Michael 
Published: July 2022

Abstract
ASXL3 loss-of-function variants represent a well-established cause of Bainbridge–Ropers syndrome, a syndromic neurodevelopmental disorder with intellectual and motor disabilities. Although a recent large-scale genomics-based study has suggested an association between ASXL3 variation and cerebral palsy, there have been no detailed case descriptions. We report, here, a female individual with a de novo pathogenic c.1210C > T, p.Gln404* nonsense variant in ASXL3, identified within the frame of an ongoing research project applying trio whole-exome sequencing to the diagnosis of dystonic cerebral palsy. The patient presented with a mixture of infantile-onset limb/trunk dystonic postures and secondarily evolving distal spastic contractures, in addition to more typical features of ASXL3-related diseases such as severe feeding issues, intellectual disability, speech impairment, and facial dysmorphic abnormalities. Our case study confirms a role for ASXL3 pathogenic variants in the etiology of cerebral-palsy phenotypes and indicates that dystonic features can be part of the clinical spectrum in Bainbridge–Ropers syndrome. ASXL3 should be added to target-gene lists used for molecular evaluation of cerebral palsy.
Unique Presentation of Occipital Condyle Giant Cell Tumor as Occipital Condyle Syndrome—A Review
Authors: Matham Gowtham , Divakar Ganesh , AN Deepti , Thomas Bejoy , HV Easwer , K. Krishnakumar 
Published: July 2022

AbstractGiant cell tumors (GCT) of the skull are rare and only a few case series with limited number of cases have been reported till date. In the cranium, GCT usually occurs in the sphenoid and temporal bone, and occipital condyle GCTs are very rare. We report a rare presentation of GCT of the occipital condyle manifested as occipital condyle syndrome. Despite gross total resection, they can recur aggressively; presence of cortical breach might be an indicator of aggressiveness prompting early postoperative imaging and adjuvant therapy.
LRBA is essential for urinary concentration and body water homeostasis
Authors: Hara Yu , Ando Fumiaki , Oikawa Daisuke , Ichimura Koichiro , Yanagawa Hideki , Sakamaki Yuriko , Nanamatsu Azuma , Fujiki Tamami , Mori Shuichi , Suzuki Soichiro , Yui Naofumi , Mandai Shintaro , Susa Koichiro , Mori Takayasu , Sohara Eisei , Rai Tatemitsu , Takahashi Mikiko , Sasaki Sei , Kagechika Hiroyuki , Tokunaga Fuminori , Uchida Shinichi 
Published: July 2022

Protein kinase A (PKA) directly phosphorylates aquaporin-2 (AQP2) water channels in renal collecting ducts to reabsorb water from urine for the maintenance of systemic water homeostasis. More than 50 functionally distinct PKA-anchoring proteins (AKAPs) respectively create compartmentalized PKA signaling to determine the substrate specificity of PKA. Identification of an AKAP responsible for AQP2 phosphorylation is an essential step toward elucidating the molecular mechanisms of urinary concentration. PKA activation by several compounds is a novel screening strategy to uncover PKA substrates whose phosphorylation levels were nearly perfectly correlated with that of AQP2. The leading candidate in this assay proved to be an AKAP termed lipopolysaccharide-responsive and beige-like anchor protein (LRBA). We found that LRBA colocalized with AQP2 in vivo, and
Lrba
knockout mice displayed a polyuric phenotype with severely impaired AQP2 phosphorylation. Most of the PKA substrates other than AQP2 were adequately phosphorylated by PKA in the absence of LRBA, demonstrating that LRBA-anchored PKA preferentially phosphorylated AQP2 in renal collecting ducts. Furthermore, the LRBA–PKA interaction, rather than other AKAP–PKA interactions, was robustly dissociated by PKA activation. AKAP–PKA interaction inhibitors have attracted attention for their ability to directly phosphorylate AQP2. Therefore, the LRBA–PKA interaction is a promising drug target for the development of anti-aquaretics.
Derivation and semantic autonomy
Authors: Kraska-Szlenk Iwona , Wójtowicz Beata 
Published: July 2022

AbstractThe article focuses on the polysemy and usage patterns of the Polish lexemegłowa“head” and its diminutivegłówka. Based on corpus methodology and cognitive linguistics analysis, it is argued that the two lexemes are too autonomous in their meanings than predicted by their morphological relatedness. As the two words cover different semantic domains, we observe that the diminutive suffix has developed a new function which signals lexicalization of meaning toward a non-human semantic domain, for example, material objects, plants, etc. Our research contributes to studies on Polish morphology and lexical semantics and to theoretical research on the polysemy of body part terms.
“They fabricated lies against us and described us in the harshest of ways”
Authors: Bartley Leanne 
Published: July 2022

Abstract
Over the past decade, Islamic State (ISIS) has made numerous attempts to propagate their beliefs on a global scale
via a range of social media platforms (e.g. Twitter), enabling them to reach an extensive audience within a very
short time span; when successful, people enlist as supporters of their ideas and, essentially, become radicalised. ISIS also
achieve this through publishing propaganda materials, such as the two online magazines Dabiq and
Rumiyah (Heidarysafa et al. 2019). In this paper, our focus lies
with the former. Through a transitivity analysis of three issues from Dabiq, this paper explores how the
in-group (the believers) and the Other (the non-believers) are represented in the magazine. The transitivity framework is
useful here because it exposes the linguistic choices that people make and, in turn, reveals how they perceive their world. To
retrieve both quantitative and qualitative findings, the UAM Corpus Tool (O’Donnell
2016) is employed.