bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Stimulating Treatment in a Certified Breast or Prostate Cancer Center
Authors: Schirrmacher Raja , Hamann Ruben , Justenhoven Christina 
Published: January 2022

Abstract
The German Cancer Society (DKG) offers certification of oncological centres since 2003. Meanwhile more than 260 and more than 120 certified centres for breast and prostate cancer, respectively, exist in Germany. Aim of the herein performed investigation was the identification of factors that stimulate treatment of patients with breast or prostate cancer in a certified centre. This study was based on information available in the database of the Cancer Registry of Rhineland-Palatinate, Germany. The impact of age, region of residence, tumor status, grading and presence of metastasis on patient’s decision with respect to a certain medical facility was analyzed by adjusted logistic regression. This investigation included data of 13,020 breast cancer and 10,904 prostate cancer patients diagnosed in the years 2016 to 2020. Overall, 59 % and 28 % of breast and prostate cancer patients, respectively, were treated in a DKG-certified centre. The analyses showed that residence in an urban region was associated with treatment in a certified centre (breast: OR 0.42, 95% CI (0.37-0.48); prostate: OR 0.46 95% CI (0.40-0.53)). In addition, older breast cancer patients were more often treated in hospitals without certificate (OR 1.13, 95% CI (1.04-1.24). Prostate cancer showed no association with age but early tumor stage (T1) were more often treated in hospitals without certificate (OR 1.23, 95% CI (1.03-1.46). In contrast, patients with more advanced tumors, T2 and T3, were likely to be reported by DKG-certified centres (OR 0.58, 95% CI (0.41-0.81) and OR 0.67, 95% CI (0.47-0.96), respectively). Most breast and more than a quarter of prostate cancer patients were treated in DKG-certified centres. The region of residence seemed to affect the decision for a certain facility for all patients. Whereas age at diagnosis and tumor status played a role for breast and prostate cancer patients, respectively.
Theoretical investigation of the complexation, structural, and electronic properties of complexes between oseltamivir drug and cucurbit[n = 6–9]urils
Authors: Rakrai Wandee , Tabtimsai Chanukorn , Kaewtong Chatthai , Wanno Banchob 
Published: January 2022

Abstract
The structural geometries of cucurbit[n]uril with n = 6–9 and their complexes with oseltamivir (OST) drug were obtained using the density functional theory computations. The stationary points of the most stable complexes were confirmed using vibrational frequency calculation. The complexation energies and electronic properties of CB[n]/OST complexes were investigated. The calculated results indicate that the intermolecular interactions in all the studied complexes occurring via a large number of dipole–dipole interactions, especially hydrogen bonds between oxygen atoms of CB[n] and hydrogen atoms of amine of oseltamivir drug. The negative complexation energies of CB[n]/OST complexes in both gas and water phases indicate that the host–guest complexes are exothermic process and the complexes are more stable than its bare CB[n]. In addition, the CB[7]/OST complex is more stable than that of all studied CB[n]/OST complexes. The frequency calculation results of the most stable complexes for each of CBs indicate that complexations are occurred via a spontaneous process. The NBO analysis of complexes shows the transferring of partial charge from CB[n]s to oseltamivir which correspond to their MEP contours. The HOMO and the LUMO orbitals are localized on the oseltamivir in CB[n]/OST complexes. After drug complexation, the electronic properties also display that, the energy gaps of CB[n] are significantly changed. All of the complexation properties point out here that CB[n]s can act as a host for appropriately oseltamivir guest, even in aqueous solution.
Securing medical data by role-based user policy with partially homomorphic encryption in AWS cloud
Authors: BOOMIJA  , S.V. Kasmir Raja 
Published: January 2022

Abstract
Cloud technology provides services for storing and accessing a large amount of data with ease of access and less cost. Sensitive data like patients' electronic health information should be encrypted before outsourcing into the cloud. Many traditional encryption methods are used for protecting data in the cloud, but unable to perform computation on encrypted data. Homomorphic encryption operates directly on the ciphertext. In this study, a Secure Partially Homomorphic Encryption (SPHE) algorithm is proposed to secure the outsourced data and perform multiplication and division operations on the ciphertext. The access control policy in the cloud environment is more flexible. An attacker can easily collect sensitive data by abusing the access policy of another user. So the database privacy is compromised. Creating a role hierarchy and managing the session is difficult in the cloud environment. The above issues motivate us to develop a model which is the integration of the proposed scheme SPHE with role-based user policy. The model is implemented in Eclipse IDE and AWS Toolkit for Eclipse and deployed in Amazon Elastic Beanstalk (EB) environment. This model is particularly used for securing the patient e-health details and performing computation on outsourced data. The patient details are encrypted by the algorithm SPHE and uploaded in AWS (Amazon Web Service) S3 bucket. The users are created by AWS Identity and Access Management (IAM) service and the access level policy is defined based on user roles in EB environment. The proposed model performance is studied by comparing with other partially homomorphic methods Elgamal, Pailler, and Benaloh. This model achieves data integrity and data confidentiality using the role-based user policy with SPHE.
Effect of the presence of Polycystic Ovary Syndrome related features on Anti-Mullerian Hormone and Androstenedione levels in adolescents with or without menstrual irregularity
Authors: HANEDAN Nurcan , Ersoy Betul , HANEDAN Candost , Özyurt Beyhan Cengiz , TANELİ Fatma 
Published: January 2022

Abstract
Purpose
To determine the variation in Anti-Mullerian Hormone (AMH) and Androstenedione (A4) concentrations in adolescent girls, with or without menstrual cycle disorder in relation to phenotypic features of PCOS.
Methods
Adolescent girls (n=129), age range 14-19 years, were recruited in the cohort study. All participants were in the 4th or 5th year after menarche. Sixty-eight had menstrual irregularities, usually oligomenorrhea (OM), and 61 had regular menstruation (RM). AMH and A4 concentrations were measured. Hirsutism was recorded. Polycystic ovarian morphology (PCOM) was evaluated by transabdominal pelvic ultrasonography. Polycystic ovary syndrome (PCOS) features were defined according to Rotterdam consensus criteria.
Results
AMH and A4 were significantly higher in adolescent girls with OM than in girls with RM (p<0.05). A4 and body mass index (BMI) of adolescents with OM was significantly higher in those with hirsutism than those without hirsutism (p=0.01 and 0.008, respectively). There was a positive correlation between A4 and BMI (r: 0.327, p<0.01). Logistic regression showed that the frequency of OM in the presence of PCOM was 10.8 times (95% CI 2.04-12.09) compared to those without PCOM. The highest AMH concentrations were found in girls with OM, hirsutism, and PCOM (p<0.05).
Conclusions
AMH and A4 are elevated in adolescents with oligomenorrhoea. High A4 is more prominent in the presence of hirsutism and is associated with increased BMI. PCOM, increases the likelihood of oligomenorrhea by about 10 times. AMH increase as the combination of clinical features of PCOS increases in adolescents with menstrual irregularity.
The Impact of Peer Support on Testing, Linkage to and Engagement in HIV Care for People Who Inject Drugs in Indonesia: Qualitative Perspectives From a Community-led Study
Authors: Iryawan Arif Rachman , Stoicescu Claudia , Sjahrial Faisyal , Nio Kuntanto , Dominich Alexa 
Published: January 2022

Abstract
Introduction: People who inject drugs (PWID) in Indonesia are disproportionately affected by HIV, but tend to be diagnosed at a late stage of infection, delay initiation to and have poor rates of retention in antiretroviral treatment, resulting in high rates of morbidity and mortality. In addition to legal, policy and health system barriers, PWID may be hesitant to engage in HIV, treatment and care due to lack of knowledge, distrust of the health care system, and stigma related to their drug use and HIV status. Implementation of formal peer support initiatives may reduce provider- and PWID LHIV-level barriers and increase testing, linkage to, and engagement in HIV care among PWID.Methods: We conducted a community-led qualitative study to explore the impacts of peer support for PWID on HIV care access and engagement in Indonesia. Semi-structured, in-depth interviews were conducted with 20 participants in Jakarta and Bandung. Thematic analysis was used to explore how PWID living with HIV (PWID LHIV) (n=8), peer support workers (n=6), and service providers (n=6) perceived peer support provision by non-governmental organisations.Results: Participants unanimously described peer support as beneficial. Peer support workers were widely credited with facilitating access to HIV testing, referral to care, uptake of and adherence to antiretroviral treatment, as well as sustaining engagement in care for PWID. Support mechanisms that facilitated positive PWID LHIV experiences included provision of HIV knowledge and awareness, emotional support, help with navigating complex bureaucracy, developing trust in health care services, enhancing confidence and motivation, and supporting peers to navigate a wide range of health and social welfare services beyond HIV-related care.Conclusions: Findings indicate that peer support can enhance access to testing, linkage to, and engagement in HIV care for PWID LHIV in Indonesia. In a context of an ongoing HIV epidemic among people who use drugs, reduced funding and policy attention to HIV and harm reduction, there is an urgent need to prioritize peer support interventions to identify people who use drugs facing health risks and link them to appropriate services.
A Mega-Analysis of the Effects of Feedback on the Quality of Simulated Child Sexual Abuse Interviews with Avatars
Authors: Pompedda Francesco , Zhang Yikang , Haginoya Shumpei , Santtila Pekka 
Published: January 2022

Abstract
The present study aimed to test the effectiveness of giving feedback on simulated avatar interview training (Avatar Training) across different experiments and participant groups and to explore the effect of professional training and parenting experience by conducting a mega-analysis of previous studies. A total of 2,208 interviews containing 39,950 recommended and 36,622 non-recommended questions from 394 participants including European and Japanese students, psychologists, and police officers from nine studies were included in the mega-analysis. Experimental conditions were dummy-coded, and all dependent variables were coded in the same way as in the previously published studies. Professional experience and parenting experience were coded as dichotomous variables and used in moderation analyses. Linear mixed effects analyses demonstrated robust effects of feedback on increasing recommended questions and decreasing non-recommended questions, improving quality of details elicited from the avatar, and reaching a correct conclusion regarding the suspected abuse. Round-wise comparisons in the interviews involving feedback showed a continued increase of recommended questions and a continued decrease of non-recommended questions. Those with (vs. without) professional and parenting experience improved faster in the feedback group. These findings provide strong support for the robustness of Avatar Training.
Simulating inequalities in social care provision during the Covid-19 pandemic: an agent-based model
Authors: Gostoli Umberto , Silverman Eric 
Published: January 2022

Abstract
The Covid-19 pandemic is deeply affecting every aspect of people daily lives around the world, both through the effects of the virus itself and the related mitigation measures put into place by governments. However, the impact of the virus is not equal within each society, as an increasing number of empirical studies show that its effects at the individual level exhibit a social gradient of health, a phenomenon known to characterize many public health outcomes. In this paper, we investigate the effect of the pandemic and related mitigation policies on social care need and supply, using a proof-of-concept agent-based model (ABM). This ABM simulates agents’ socioeconomic status, kinship networks, and heterogeneous behavioural responses to the pandemic. We propose that such models may help policymakers develop more effective policies to mitigate viral spread, that can take into account the unequal impact of the pandemic on individuals in different socioeconomic status groups. The social care outcomes in the model also illustrate that policy solutions aimed at controlling the pandemic may have substantial effects on the level of unmet social care need.
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
Authors: Yauch Robert , Cantley Jennifer , Ye Xiaofen , Rousseau Emma , Januario Tom , Hamman Brian , Rose Chris , Cheung Tommy , Hickle Trent , Soto Leofal , Quinn Connor , Harbin Alicia , Bortolon Elizabeth , Chen Xin , Haskell Roy , Lin Eva , Yu Shang-Fan , Del-Rosario Geoff , Chen Emily , Martin Scott , Merchant Mark , Grimmer Matthew , Broccatelli Fabio , Wang Jing , Pizzano Jennifer , Dragovich Peter , Berlin Michael 
Published: January 2022

Abstract
The mammalian SWI/SNF helicase SMARCA4 is frequently mutated in cancer and inactivation results in a cellular dependence on its paralog, SMARCA2, thus making SMARCA2 an attractive synthetic lethal target. However, published data indicates that achieving a high degree of selective SMARCA2 inhibition is likely essential to afford an acceptable therapeutic index, and realizing this objective has been challenging due to the homology with the SMARCA4 paralog. Herein we report the discovery of the first potent and selective SMARCA2 proteolysis-targeting chimera (PROTAC) molecule (A947). Selective SMARCA2 degradation was achieved in the absence of selective SMARCA2/4 PROTAC binding and translated to potent in vitro growth inhibition and in vivo efficacy in SMARCA4 mutant models, compared to wild type models. Global ubiquitin mapping and proteome profiling revealed no unexpected off-target degradation related to A947 treatment. Our study thus highlights the ability to transform a non-selective SMARCA2/4-binding ligand into a selective and efficacious in vivo SMARCA2-targeting PROTAC, and thereby provides a potential new therapeutic opportunity for patients whose tumors contain SMARCA4 mutations.
Evaluation of Flow Resistance in Gravel-Bed Channels with Bed-Load Transport by using Multi-Gene Genetic Programming
Authors: Kumar Satish , Pradhan Arpan , Khuntia Jnana Ranjan , Khatua Kishanjit Kumar 
Published: January 2022

Abstract
Evaluation of flow resistance is necessary for the computation of conveyance capacity in open channels. For the case of channels with bedload conditions, the significance of the friction factor is of paramount importance. The gravel-bed channel response for a bedload transport condition in terms of flow resistance is distinct from that of a fixed bed and requires a different evaluation technique. The paper studies the different empirical approaches by various authors to determine the friction factor under bedload transport conditions and proposes an expression using genetic programming to derive the same. Flow resistance in the bedload transport condition is affected by various hydraulic as well as geometric parameters. In the present study, the factors proposed to be influencing friction factor for such a flow condition are undertaken as bed slope, relative submergence depth, aspect ratio, Reynolds number, and Froude number. A wide range of experimental datasets is used to determine the effect of these influencing parameters. The predictability of the proposed model is compared to the various empirical equations in literature. The proposed model is observed to effectively predict the friction factor for a wide range of datasets, unlike the existing models. The evaluated value of the friction factor from different models is used to validate the conveyance capacity of a river. The developed Multi-Gene Genetic Programming (MGGP) model is observed to reasonably predict discharge in the river, signifying that the model is competent to be applied to field study, within the specified range of parameters.
Effect of COVID-19 Pandemic on HIV/AIDS, Tuberculosis, Malaria, and Maternal and Child Health Services, Uganda, 2020
Authors: Emong Daniel Jacob , Wadunde Ignatius , Kadobera Daniel , Bulage Lilian , Kabwama Steven Ndugwa , Ario Alex Riolexus 
Published: January 2022

Abstract
Background: Access to healthcare services has been severely compromised in many countries by the COVID-19 pandemic. By June 30, 2020 Uganda had not gathered enough information on the impact of COVID-19 on healthcare services. We assessed the effect of COVID-19 pandemic on human immunodeficiency virus (HIV), Tuberculosis (TB), Malaria, and Maternal and Child Health (MCH) services.Methods: We conducted a cross-sectional assessment during July 2020 in randomly selected health facilities across the four geographical regions of Uganda. We abstracted data on the number of clients seeking healthcare services from, the Out-Patient Department (OPD), HIV, TB, malaria, and MCH facility registers before (January-February) and during (April-May) the pandemic. We compared the outcomes before and during using the paired t-test. Results: We assessed 28 facilities. There was a significant decrease in average outpatient department total attendances from (M=5,529, SD=6541.2) before compared to (M=3576, SD=4345.6) during COVID-19 pandemic (P=0.0031). Similarly, the average number screened for TB significantly decreased from (M=2822, SD=5409.2) to (M=1300, SD=2525.5) P=0.040 and ANC 1st contacts from (M=200 SD=207.8) before to (M=137, SD=133.3) during COVID-19 pandemic p = 0.015. Conclusion: A significant number of the population may not have readily accessed healthcare services during the pandemic especially those with long term illnesses like TB and HIV. We developed Information, Education and Communication materials and conducted a catch-up campaign for TB. Awareness creation among service providers on reduced intake of HIV and MCH services during COVID-pandemic is needed for enhancement of community education.
The Polymorphism of Producing Public Goods in an Evolutionary Volunteer's Dilemma Game
Authors: Guo Zi-Xuan , Perc Matjaž , Li Qing-Ming , Shi Lei , Wang Rui-Wu , He Jun-Zhou 
Published: January 2022

Abstract
There is an inconsistency between theory and observations with regards to the contributions of strong and weak players to the public goods. Theory suggests that contributors are either strong players in asymmetric games or cooperative players in symmetric games, but experiments indicate that the weak players in asymmetric systems also contribute to public goods. To reconciling these conflicts, we here study an evolutionary volunteer's dilemma game by assuming different roles can be interchangeable. In this model, the evolutionary dynamics shows the dynamics of multiple equilibria that depend on initial conditions, which can be interpreted as the production modes of public goods under different circumstances. Precisely, we find that the survival of strong individuals with mixed strategies is associated with two different outcomes. One result is equal to Selten's (1980) model, and public goods are produced by strong players if the defectors are weak players, where strong defectors are scarce in the initial condition. In another result, the weak individuals with mixed strategies produce public goods if the defectors are strong individuals, where the strong cooperators are absent in the initial condition. Concretely, the game degenerates to a mixed population of strong individuals with the weak players going extinct, and the weak defectors are scarce in the initial condition. The studied evolutionary game may help to explain the emergence of diverse forms of cooperation in asymmetric evolutionary games.
Association of high cortisol levels in pregnancy and poor postpartum mental health and altered fetal growth. Analysis in the MAASTHI cohort study, Bengaluru
Authors: Babu Giridhara R , Shriyan Prafulla , Sudhir Paulomi , Schayck Onno CP 
Published: January 2022

Abstract
Background: The role of maternal stress levels on mothers’ mental health and fetal growth has been previously studied. We aim to investigate the association of serum cortisol level in pregnancy with birth outcomes and postpartum depressive symptoms in a public health facility, India. Methods: The current study is a part of the MAASTHI prospective cohort that assessed the relationship between maternal psychosocial environment and adverse neonatal outcomes and maternal mental health after birth. We assessed serum cortisol levels in stored blood samples in 230 pregnant women as a biomarker for stress during pregnancy. Pregnant women between 18 and 45 years of age, presenting at ≥ 14 weeks of gestation and providing voluntary written informed consent were recruited in the study. The Edinburgh Postnatal Depression Scale was used to assess postpartum depressive symptoms and detailed infant anthropometric measurements were carried out at birth. Results: A serum cortisol threshold value of >17.60 IU/L seemed to be associated with postpartum depressive symptoms, low birth weight, and lower weight for length/height z-score. No significant association was found between serum cortisol and infants reduced head circumference, the sum of skinfold thickness, and crown-rump length. Conclusion: Our results support the hypothesis that higher maternal cortisol levels may adversely affect a mother's mental health and birth outcomes. These findings have implications for understanding maternal mental health and early developmental psychopathology, both of which are well-known but understudied. Future studies should explore this association at various gestational ages and use epigenetic markers to determine hypothalamic-pituitary axis (HPA) activity during pregnancy and its effect on birth outcomes.