bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
Authors: Nakajima Tamie , Wang Hailan , Yuan Yuan , Ito Yuki , Naito Hisao , Kawamoto Yoshiyuki , Takeda Kozue , Sakai Kiyoshi , Zhao Na , Li Hongling , Qiu Xinxiang , Xia Lihua , Chen Jiabin , Wu Qifeng , Li Laiyu , Huang Hanlin , Yanagiba Yukie , Yatsuya Hiroshi , Kamijima Michihiro 
Published: June 2022

AbstractOccupational exposure to trichloroethylene (TCE) causes a systemic skin disorder with hepatitis known as TCE hypersensitivity syndrome (TCE-HS). Human Leukocyte Antigen (HLA)-B*13:01 is its susceptibility factor; however, the immunological pathogenesis of TCE-HS remains unknown. We herein examined the hypothesis that autoantibodies to CYP2E1 are primarily involved in TCE-HS. A case–control study of 80 TCE-HS patients, 186 TCE-tolerant controls (TCE-TC), and 71 TCE-nonexposed controls (TCE-nonEC) was conducted to measure their serum anti-CYP2E1 antibody (IgG) levels. The effects of TCE exposure indices, such as 8-h time-weighted-average (TWA) airborne concentrations, urinary metabolite concentrations, and TCE usage duration; sex; smoking and drinking habits; and alanine aminotransferase (ALT) levels on the antibody levels were also analyzed in the two control groups. There were significant differences in anti-CYP2E1 antibody levels among the three groups: TCE-TC > TCE-HS patients > TCE-nonEC. Antibody levels were not different between HLA-B*13:01 carriers and noncarriers in TCE-HS patients and TCE-TC. The serum CYP2E1 measurement suggested increased immunocomplex levels only in patients with TCE-HS. Multiple regression analysis for the two control groups showed that the antibody levels were significantly higher by the TCE exposure. Women had higher antibody levels than men; however, smoking, drinking, and ALT levels did not affect the anti-CYP2E1 antibody levels. Anti-CYP2E1 antibodies were elevated at concentrations lower than the TWA concentration of 2.5 ppm for TCE exposure. Since HLA-B*13:01 polymorphism was not involved in the autoantibody levels, the possible mechanism underlying the pathogenesis of TCE-HS is that TCE exposure induces anti-CYP2E1 autoantibody production, and HLA-B*13:01 is involved in the development of TCE-HS.
The effects of alcohol and co-witness information on memory reports: a field study
Authors: Bartlett Georgina , Albery Ian P. , Frings Daniel , Gawrylowicz Julie 
Published: June 2022

Abstract

Rationale
Witnesses who discuss a crime together may report details that they did not see themselves but heard about from their co-witness. Co-witness information may have beneficial and harmful effects on memory accuracy depending on whether the information was correct or incorrect.

Objectives
Given the prevalence of intoxicated witnesses, it is imperative to understand how alcohol influences this effect.

Methods
The present study asked pubgoers (n = 67) at varying levels of intoxication to recall a mock crime video after having also watched a video witness statement containing both correct and false information.

Results
Increased intoxication was associated with decreased confidence, completeness and accuracy, but no increased tendency to report false information. Exposure to incorrect post-event information (PEI) can lead to the incorporation of incorrect information, whereas exposure to correct PEI increased accuracy, regardless of individuals’ alcohol intoxication status.

Conclusions
Thus, whilst discussion and intoxication can negatively impact eyewitness memory, discussion may also have benefits for both sober and intoxicated witnesses.
Anatomy for right ventricular lead implantation
Authors: Israel Carsten W. , Tribunyan Sona , Yen Ho S. , Cabrera José A. 
Published: June 2022

AbstractTo understand the position of a pacing lead in the right ventricle and to correctly interpret fluoroscopy and intracardiac signals, good anatomical knowledge is required. The right ventricle can be separated into an inlet, an outlet, and an apical compartment. The inlet and outlet are separated by the septomarginal trabeculae, while the apex is situated below the moderator band. A lead position in the right ventricular apex is less desirable, last but not least due to the thin myocardial wall. Many leads supposed to be implanted in the apex are in fact fixed rather within the trabeculae in the inlet, which are sometimes difficult to pass. In the right ventricular outflow tract (RVOT), the free wall is easier to reach than the septal due to the fact that the RVOT wraps around the septum. A mid-septal position close to the moderator band is relatively simple to achieve and due to the vicinity of the right bundle branch may produce a narrower paced QRS complex. Special and detailed knowledge is necessary for His bundle and left bundle branch pacing.
Combination therapy of doxorubicin and Sildenafil inhibits the growth of pediatric rhabdomyosarcoma
Authors: Urla Cristian , Stagno Matias Julian , Fuchs Jörg , Warmann Steven Walter , Schmid Evi 
Published: June 2022

Abstract
Background
Overexpression of phosphodiesterase type 5 (PDE5) has been detected in many types of malignant tumors. Sildenafil, a potent and selective inhibitor of a cGMP-specific PDE5, has been found to enhance the cytotoxic activity of different chemotherapeutic agents including doxorubicin. The combined therapy of doxorubicin with Sildenafil might reduce the possible side effects of chemotherapy while maintaining synergistic anticancer activity. The present study explored for the first time the effects of Sildenafil, alone and in combination with doxorubicin, on pediatric RMS cells.

Methods
Human RMS cells lines RH30 and RD were used. Western blotting and RT-PCR were performed to analyze PDE5 expression in RMS cells. Cell viability was determined using MTT assay. Cell migration was analyzed via transwell chambers, clonal growth and mitotic cell death were analyzed using the clonogenic assay. FACS analysis was performed to evaluate reactive oxygen species (ROS) and apoptosis.

Results
Sildenafil significantly decreased cell viability and migration of RD and RH30 cells. The exposure of RMS cells to doxorubicin resulted in a dose-dependent decrease in their viability. Simultaneous administration of Sildenafil enhanced this effect. The incubation of the RMS cells with Sildenafil in the presence of doxorubicin significantly increased the proportion of apoptotic cells and ROS production compared to the treatment with Sildenafil alone.

Conclusions
The results of our study indicate a link between PDE5 inhibition by Sildenafil and decreased calcium signalling leading to significantly impaired viability, migration, and colony forming of RMS cells. Increased ROS production and apoptosis are mechanisms relevantly contributing to this observation.
Evaluation of the precision of navigation-assisted endoscopy according to the navigation tool setup and the type of endoscopes
Authors: Chavaz Lara , Davidovic Alioucha , Meling Torstein R. , Momjian Shahan , Schaller Karl , Bijlenga Philippe , Haemmerli Julien 
Published: June 2022

Abstract
Object
Preoperative image-based neuronavigation-assisted endoscopy during intracranial procedures is gaining great interest. This study aimed to analyze the precision of navigation-assisted endoscopy according to the navigation setup, the type of optic and its working angulation.

Methods
A custom-made box with four screws was referenced. The navigation-assisted endoscope was aligned on the screws (targets). The precision on the navigation screen was defined as the virtual distance-to-target between the tip of the endoscope and the center of the screws. Three modifiers were assessed: (1) the distance D between the box and the reference array (CLOSE 13 cm – MIDDLE 30 cm – FAR 53 cm), (2) the distance between the tip of the endoscope and the navigation array on the endoscope (close 5 cm – middle 10 cm – far 20 cm), (3) the working angulation of the endoscope (0°-endoscope and 30°-endoscope angled at 90° and 45° with the box).

Results
The median precision was 1.3 mm (Q1: 1.1; Q3: 1.7) with the best setting CLOSE/close. The best setting in surgical condition (CLOSE/far) showed a distance-to-target of 2.3 mm (Q1: 1.9; Q3: 2.5). The distance D was correlated to the precision (Spearman rho = 0.82), but not the distance d (Spearman rho = 0.04). The type of optic and its angulation with the box were also correlated to the precision (Spearman rho =  − 0.37). The best setting was the use of a 30°-endoscope angled at 45° (1.4 mm (Q1: 1.0; Q3: 1.9)).

Conclusion
Navigated-assisted endoscopy is feasible and offers a good precision. The navigation setup should be optimized, reducing the risk of inadvertent perifocal damage.
The wage effects of offshoring to the East and West: evidence from the German labor market
Authors: Koerner Konstantin 
Published: June 2022

AbstractThis paper analyzes the labor market effects of offshoring in a high-wage home country and how these effects crucially depend on (1) Job complexity and (2) The characteristics of the destination country. It thereby links several sources: rich administrative data on individuals and plants in the German manufacturing industries, information on a job's task bundle, and the evolution of imported inputs from low- or high-wage destinations, which are represented by Eastern and Western Europe, respectively. Offshoring to these origins has opposing effects on German wages with respect to the relative task complexity of jobs: While offshoring to the West puts pressure on the wages of complex jobs and increases the wages of simple jobs, offshoring to the East entails the opposite effect. The overall effect adds up to a 4.2 percent increase in wages for jobs with high complexity, while low-complexity jobs see a 3.9 percent decrease in wages.
Does import competition drive productivity growth? Evidence from Hungary’s pre-accession import tariffs
Authors: Maduko Franklin 
Published: June 2022

AbstractThis paper studies the effect of increased competition from imports on the productivity of firms. It proposes an empirical model that estimates productivity from sales revenue. The model addresses concerns associated with unobserved prices and demand conditions in revenue productivity. Unlike De Loecker (Econometrica 79(5):1407–1451, 2011), the model builds on recent evidence on the effect of exporting on firm-level prices by distinguishing between the export and domestic demand markets and integrating both in the supply function of firms. It applies this framework to study the effect that tariffs reduction on EU imports had on the efficiency of manufacturing firms in Hungary during the period 1996–2003, and finds that a 10-percentage point reduction in import tariffs on similar products manufactured by a firm raises the firm’s productivity by 1.40%. This is in contrast to 2.35% when revenue productivity is used. The proposed model provides a simple framework that improves productivity estimates from sales data.
Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics
Authors: Vasishta Sampara , Ganesh Kailash , Umakanth Shashikiran , Joshi Manjunath B 
Published: June 2022

AbstractType 2 diabetes (T2D) associated health disparities among different ethnicities have long been known. Ethnic variations also exist in T2D related comorbidities including insulin resistance, vascular complications and drug response. Genetic heterogeneity, dietary patterns, nutrient metabolism and gut microbiome composition attribute to ethnic disparities in both manifestation and progression of T2D. These factors differentially regulate the rate of metabolism and metabolic health. Metabolomics studies have indicated significant differences in carbohydrate, lipid and amino acid metabolism among ethnicities. Interestingly, genetic variations regulating lipid and amino acid metabolism might also contribute to inter-ethnic differences in T2D. Comprehensive and comparative metabolomics analysis between ethnicities might help to design personalized dietary regimen and newer therapeutic strategies. In the present review, we explore population based metabolomics data to identify inter-ethnic differences in metabolites and discuss how (a) genetic variations, (b) dietary patterns and (c) microbiome composition may attribute for such differences in T2D.
Computational simulation of the flow dynamic field in a porous ureteric stent
Authors: Yang Xiaohan , Mosayyebi Ali , Carugo Dario 
Published: June 2022

AbstractUreteric stents are employed clinically to manage urinary obstructions or other pathological conditions. Stents made of porous and biodegradable materials have gained increasing interest, because of their excellent biocompatibility and the potential for overcoming the so-called ‘forgotten stent syndrome’. However, there is very limited characterisation of their flow dynamic performance. In this study, a CFD model of the occluded and unoccluded urinary tract was developed to investigate the urinary flow dynamics in the presence of a porous ureteric stent. With increasing the permeability of the porous material (i.e., from 10−18 to 10−10 m2) both the total mass flow rate through the ureter and the average fluid velocity within the stent increased. In the unoccluded ureter, the total mass flow rate increased of 7.7% when a porous stent with permeability of 10−10 m2 was employed instead of an unporous stent. Drainage performance further improved in the presence of a ureteral occlusion, with the porous stent resulting in 10.2% greater mass flow rate compared to the unporous stent. Findings from this study provide fundamental insights into the flow performance of porous ureteric stents, with potential utility in the development pipeline of these medical devices.
Graphical abstract
A novel pathway to detect muscle-invasive bladder cancer based on integrated clinical features and VI-RADS score on MRI: results of a prospective multicenter study
Authors: Bicchetti Marco , Simone Giuseppe , Giannarini Gianluca , Girometti Rossano , Briganti Alberto , Brunocilla Eugenio , Cardone Gianpiero , De Cobelli Francesco , Gaudiano Caterina , Del Giudice Francesco , Flammia Simone , Leonardo Costantino , Pecoraro Martina , Schiavina Riccardo , Catalano Carlo , Panebianco Valeria 
Published: June 2022

Abstract
Purpose
To determine the clinical, pathological, and radiological features, including the Vesical Imaging-Reporting and Data System (VI-RADS) score, independently correlating with muscle-invasive bladder cancer (BCa), in a multicentric national setting.

Method and Materials
Patients with BCa suspicion were offered magnetic resonance imaging (MRI) before trans-urethral resection of bladder tumor (TURBT). According to VI-RADS, a cutoff of ≥ 3 or ≥ 4 was assumed to define muscle-invasive bladder cancer (MIBC). Trans-urethral resection of the tumor (TURBT) and/or cystectomy reports were compared with preoperative VI-RADS scores to assess accuracy of MRI for discriminating between non-muscle-invasive versus MIBC. Performance was assessed by ROC curve analysis. Two univariable and multivariable logistic regression models were implemented including clinical, pathological, radiological data, and VI-RADS categories to determine the variables with an independent effect on MIBC.

Results
A final cohort of 139 patients was enrolled (median age 70 [IQR: 64, 76.5]). MRI showed sensitivity, specificity, PPV, NPV, and accuracy for MIBC diagnosis ranging from 83–93%, 80–92%, 67–81%, 93–96%, and 84–89% for the more experienced readers. The area under the curve (AUC) was 0.95 (0.91–0.99). In the multivariable logistic regression model, the VI-RADS score, using both a cutoff of 3 and 4 (P < .0001), hematuria (P = .007), tumor size (P = .013), and concomitant hydronephrosis (P = .027) were the variables correlating with a bladder cancer staged as ≥ T2. The inter-reader agreement was substantial (k = 0.814).

Conclusions
VI-RADS assessment scoring proved to be an independent predictor of muscle-invasiveness, which might implicate a shift toward a more aggressive selection approach of patients’ at high risk of MIBC, according to a novel proposed predictive pathway.
Differentiating solitary brain metastases from high-grade gliomas with MR: comparing qualitative versus quantitative diagnostic strategies
Authors: Voicu Ioan Paul , Pravatà Emanuele , Panara Valentina , Navarra Riccardo , Mattei Peter A. , Caulo Massimo 
Published: June 2022

Abstract
Purpose
To investigate the diagnostic efficacy of MRI diagnostic algorithms with an ascending automatization, in distinguishing between high-grade glioma (HGG) and solitary brain metastases (SBM).

Methods
36 patients with histologically proven HGG (n = 18) or SBM (n = 18), matched by size and location were enrolled from a database containing 655 patients. Four different diagnostic algorithms were performed serially to mimic the clinical setting where a radiologist would typically seek out further findings to reach a decision: pure qualitative, analytic qualitative (based on standardized evaluation of tumor features), semi-quantitative (based on perfusion and diffusion cutoffs included in the literature) and a quantitative data-driven algorithm of the perfusion and diffusion parameters. The diagnostic yields of the four algorithms were tested with ROC analysis and Kendall coefficient of concordance.

Results
Qualitative algorithm yielded sensitivity of 72.2%, specificity of 78.8%, and AUC of 0.75. Analytic qualitative algorithm distinguished HGG from SBM with a sensitivity of 100%, specificity of 77.7%, and an AUC of 0.889. The semi-quantitative algorithm yielded sensitivity of 94.4%, specificity of 83.3%, and AUC = 0.889. The data-driven algorithm yielded sensitivity = 94.4%, specificity = 100%, and AUC = 0.948. The concordance analysis between the four algorithms and the histologic findings showed moderate concordance for the first algorithm, (k = 0.501, P < 0.01), good concordance for the second (k = 0.798, P < 0.01), and third (k = 0.783, P < 0.01), and excellent concordance for fourth (k = 0.901, p < 0.0001).

Conclusion
When differentiating HGG from SBM, an analytical qualitative algorithm outperformed qualitative algorithm, and obtained similar results compared to the semi-quantitative approach. However, the use of data-driven quantitative algorithm yielded an excellent differentiation.
Internationale Supervisionsforschung revisited: Trends, Highlights und Desiderate
Authors: Schigl Brigitte 
Published: June 2022

ZusammenfassungIn dem Beitrag werden eine Analyse der internationalen Supervisionsforschung skizziert und einige Verbindungen zur Coachingforschung angedacht: In einem Literaturreview werden deutsch- und englischsprachige Publikationen empirischer Studien zu Supervision ausgewertet. Dabei werden die Diversität der Definitionen des Forschungsgegenstandes Supervision, Themen und Forschungsanliegen, Forschungsfragen und -methoden erörtert sowie einige interessante Ergebnisse und Designs vorgestellt. Die Schlussfolgerungen verweisen v. a. auf die Notwendigkeit einer stärkeren Vernetzung der community der Supervisionsforscher:innen, um einen State of the Art und body of knowledge zu konstituieren.
How artificiality and intelligence affect voice assistant evaluations
Authors: Guha Abhijit , Bressgott Timna , Grewal Dhruv , Mahr Dominik , Wetzels Martin , Schweiger Elisa 
Published: June 2022

AbstractWidespread, and growing, use of artificial intelligence (AI)–enabled voice assistants (VAs) creates a pressing need to understand what drives VA evaluations. This article proposes a new framework wherein perceptions of VA artificiality and VA intelligence are positioned as key drivers of VA evaluations. Building from work on signaling theory, AI, technology adoption, and voice technology, the authors conceptualize VA features as signals related to either artificiality or intelligence, which in turn affect VA evaluations. This study represents the first application of signaling theory when examining VA evaluations; also, it is the first work to position VA artificiality and intelligence (cf. other factors) as key drivers of VA evaluations. Further, the paper examines the role of several theory-driven and/ or practice-relevant moderators, relating to the effects of artificiality and intelligence on VA evaluations. The results of these investigations can help firms suitably design their VAs and suitably design segmentation strategies.
Impact of artificial intelligence in breast cancer screening with mammography
Authors: Dang Lan-Anh , Chazard Emmanuel , Poncelet Edouard , Serb Teodora , Rusu Aniela , Pauwels Xavier , Parsy Clémence , Poclet Thibault , Cauliez Hugo , Engelaere Constance , Ramette Guillaume , Brienne Charlotte , Dujardin Sofiane , Laurent Nicolas 
Published: June 2022

Abstract
Objectives
To demonstrate that radiologists, with the help of artificial intelligence (AI), are able to better classify screening mammograms into the correct breast imaging reporting and data system (BI-RADS) category, and as a secondary objective, to explore the impact of AI on cancer detection and mammogram interpretation time.

Methods
A multi-reader, multi-case study with cross-over design, was performed, including 314 mammograms. Twelve radiologists interpreted the examinations in two sessions delayed by a 4 weeks wash-out period with and without AI support. For each breast of each mammogram, they had to mark the most suspicious lesion (if any) and assign it with a forced BI-RADS category and a level of suspicion or “continuous BI-RADS 100”.

Cohen’s kappa correlation coefficient evaluating the inter-observer agreement for BI-RADS category per breast, and the area under the receiver operating characteristic curve (AUC), were used as metrics and analyzed.

Results
On average, the quadratic kappa coefficient increased significantly when using AI for all readers [κ = 0.549, 95% CI (0.528–0.571) without AI and κ = 0.626, 95% CI (0.607–0.6455) with AI]. AUC was significantly improved when using AI (0.74 vs 0.77, p = 0.004). Reading time was not significantly affected for all readers (106 s without AI and vs 102 s with AI; p = 0.754).

Conclusions
When using AI, radiologists were able to better assign mammograms with the correct BI-RADS category without slowing down the interpretation time.
RETALT: review of technologies and overview of design changes
Authors: Marwege Ansgar , Gülhan Ali , Klevanski Josef , Hantz Christian , Karl Sebastian , Laureti Mariasole , De Zaiacomo Gabriele , Vos Jan , Jevons Matthew , Thies Christoph , Krammer Anett , Lichtenberger Marc , Carvalho João , Paixão Sofia 
Published: June 2022

AbstractRETALT (RETro propulsion Assisted Landing Technologies) is a project funded in the frame of the European Union Horizon 2020 program, that is studying critical key technologies for the vertical landing of launcher configurations with the aid of retro propulsion. In particular Aerodynamics, Aerothermodynamics, Flight Dynamics and Guidance Navigation and Control (GNC), Structures, Mechanisms, Thrust Vector Control and Thermal Protection Systems are investigated in detail in the project. This paper provides an overview of the technological achievements in these different technological areas, with emphasis on the interaction between them. Design changes made to the RETALT1 configuration are laid out in detail. The novel approach of using interstage segments as aerodynamic control surfaces proved to be challenging from the aerodynamics, flight dynamics, mechanical and structural points of view. For this reason, planar fins were introduced as aerodynamic control surfaces in the new base line configuration for RETALT1. The paper concludes with a summary of future steps to be made in the RETALT project to reach the targeted Technology Readiness Level (TRL) of the different key technologies.