bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes on chest HRCT in systemic sclerosis-related interstitial lung disease after autologous haematopoietic stem cell transplantation
Authors: Pugnet Grégory , Petermann Antoine , Collot Samia , Otal Philippe , Lansiaux Pauline , Ait Abdallah Nassim , Lorillon Gwenaëlle , Resche-Rigon Mathieu , Borel Cécile , Marjanovic Zora , Farge Dominique ,   for the MATHEC-SFGM-TC network
Published: June 2022

Abstract

Objective
To evaluate extent of interstitial lung disease (ILD) and oesophageal involvement using high-resolution computed tomography (HRCT) in early diffuse SSc patients after autologous haematopoietic stem cell transplantation (aHSCT).

Methods
Overall chest HRCT, lung function and skin score changes were evaluated in 33 consecutive diffuse SSc patients before and after aHSCT during yearly routine follow-up visits between January 2000 and September 2016. Two independent radiologists blindly assessed the ILD extent using semi-quantitative Goh and Wells method, the widest oesophageal diameter (WOD) and the oesophageal volume (OV) on HRCT. Patients were retrospectively classified as radiological responders or non-responders, based on achieved stability or a decrease of 5% or more of HRCT-ILD at 24 months post-aHSCT.

Results
Using a linear mixed model, the regressions of the extent of ILD and of ground glass opacities were significant at 12 months (ILD P = 0.001; ground glass opacities P = 0.0001) and at 24 months (ILD P = 0.007; ground glass opacities P = 0.0008) after aHSCT, with 18 patients classified as radiological responders (probability of response 0.78 [95% CI 0.58, 0.90]). Meanwhile the WOD and the OV increased significantly at 12 months (WOD P = 0.03; OV P = 0.34) and at 24 months (WOD P = 0.002; OV P = 0.007). Kaplan–Meier analyses showed a trend towards better 5-year survival rates (100% vs 60%; hazard ratio 0.23 [95% CI 0.03, 1.62], P = 0.11) among radiological responders vs non-responders at 24 month follow-up after aHSCT.

Conclusion
Real-world data analysis confirmed significant improvement in extent of HRCT SSc-ILD 24 months after aHSCT, although oesophageal dilatation worsened requiring specific attention.
The BILAG-2004 index is associated with development of new damage in SLE
Authors: Yee Chee-Seng , Gordon Caroline , Akil Mohammed , Lanyon Peter , Edwards Christopher J , Isenberg David A , Rahman Anisur , Teh Lee-Suan , Tosounidou Sofia , Stevens Robert , Prabu Athiveeraramapandian , Griffiths Bridget , McHugh Neil , Bruce Ian N , Ahmad Yasmeen , Khamashta Munther A , Farewell Vernon T 
Published: June 2022

Abstract

Objective
To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined.

Methods
This was a multicentre longitudinal study. Patients were recruited within 12 months of achieving fourth ACR classification criterion for SLE. Data were collected on disease activity, damage, SLE-specific drug exposure, cardiovascular risk factors, antiphospholipid syndrome status and death at every visit. This study ran from 1 January 2005 to 31 December 2017. Descriptive statistics were used to analyse mortality and development of new damage. Poisson regression was used to examine potential explanatory variables for development of new damage.

Results
A total of 273 SLE patients were recruited with total follow-up of 1767 patient-years (median 73.4 months). There were 6348 assessments with disease activity scores available for analysis. During follow-up, 13 deaths and 114 new damage items (in 83 patients) occurred. The incidence rate for development of damage was higher in the first 3 years before stabilizing at a lower rate. Overall rate for damage accrual was 61.1 per 1000 person-years (95% CI: 50.6, 73.8). Analysis showed that active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage. Low disease activity (LDA) states [BILAG-2004 LDA and BILAG Systems Tally (BST) persistent LDA] were inversely associated with development of damage.

Conclusions
BILAG-2004 index is associated with new damage. BILAG-2004 LDA and BST persistent LDA can be considered as treatment targets.
Care to Persist: A Campaign to Ensure Nursing Student Success During A Time of Crisis
Authors: DeVaughn Valerie , Minnick Amy , Sherer Amy 
Published: June 2022

Abstract
Student persistence is crucial for preparing nurses to meet the demands of an ever-changing health care environment. The RN to BSN Online Degree Completion Option at a large for-profit university implemented the Care to Persist campaign in 2018 to support student persistence. This campaign evolved during the COVID-19 pandemic and has been a critical component in ensuring students’ success. First-term session-to-session persistence rates improved from 81.2 percent in May 2019 to 85.2 percent in May 2021. The campaign has been a beneficial strategy to care for students and ensure academic progression both before and during the pandemic.
Rapid Transition to Virtual Assessment and Treatment in an Interdisciplinary Randomized Clinical Trial for Youth With Chronic Pain
Authors: Shear Deborah , Harrison Lauren E. , O’Brien Shannon , Khazendar Zeena , Lyons Samuel , Morgan Jeffery J. , Chan Salinda K. , Feinstein Amanda B. , Simons Laura E. 
Published: June 2022

Objectives:COVID-19 abruptly halted in-person clinical care and research requiring a shift to virtual assessment and treatment. This unexpected transition of a 2-arm randomized controlled trial (RCT) examining interdisciplinary graded exposure treatment (GET Living) compared with multidisciplinary pain management for youth with chronic pain provided an opportunity to implement the first remotely delivered exposure treatment and remotely delivered biomechanical assessment for pediatric chronic pain. Here we describe these new approaches and provide lessons learned to inform future efforts in digital health care.Methods:A total of 68 youth (M=14.2 y; 80.9% female) were enrolled in the RCT (n=31 in-person, n=5 hybrid, n=32 virtual, n=9 withdrew). Of those withdrawn, n=3 withdrew due to COVID-19 related reasons. Some RCT elements required slight modification (eg, e-consent, actigraphy deployment, recruitment, and screening), while others were significantly altered (eg, session format and lab-based biomechanical assessment). Data from exit interviews were also examined to assess perspectives on the virtual format transition.Results:Results showed an increased enrollment rate when virtual care was an option (70.7%) compared with in-person (44.3%). Equivalent rates of completion for daily assessment (in-person, 72.8%; virtual, 73.3) were also observed, and participants described enhanced experience when able to complete exercises and exposures in their home environment during session (vs. a rehabilitation gym) allowing for genuine in vivo exposures (eg, household chores, riding bicycles).Discussion:Overall, our data demonstrate acceptability, feasibility, and equivalent patient engagement to virtual treatment. Novel methods implemented in this RCT can inform trial design and measures of clinical endpoints for future digital health interventions.
What Are the Mechanisms of Action of Cognitive–Behavioral, Mind–Body, and Exercise-based Interventions for Pain and Disability in People With Chronic Primary Musculoskeletal Pain?
Authors: Alaiti Rafael K. , Castro Julia , Lee Hopin , Caneiro J.P. , Vlaeyen Johan W.S. , Kamper Steven J. , da Costa Marcelo F. 
Published: June 2022

Objectives:
This systematic review examined studies that used mediation analysis to investigate the mechanisms of action of cognitive–behavioral, mind–body, and exercise-based interventions for pain and disability in people with chronic primary musculoskeletal pain.

Materials and Methods:
We searched 5 electronic databases for articles that conducted mediation analyses of randomized controlled trials to either test or estimate indirect effects.

Results:
We found 17 studies (n=4423), including 90 mediation models examining the role of 22 putative mediators on pain or disability, of which 4 had partially mediated treatment effect; 8 had mixed results, and 10 did not mediate treatment effect. The conditions studied were chronic whiplash-associated pain, chronic low back pain, chronic knee pain, and mixed group of chronic primary musculoskeletal pain.

Discussion:
We observed that several of the studies included in our systematic review identified similar mechanisms of action, even between different interventions and conditions. However, methodological limitations were common. In conclusion, there are still substantial gaps with respect to understanding how cognitive–behavioral, mind–body, and exercise-based interventions work to reduce pain and disability in people with chronic primary musculoskeletal pain.
Pain and Fear of Cancer Recurrence in Survivors of Childhood Cancer
Authors: Tutelman Perri R. , Chambers Christine T. , Noel Melanie , Heathcote Lauren C. , Fernandez Conrad V. , Flanders Annette , MacLeod Julia , Sherry Simon B. , Simard Sébastien , Stern Maya , Stewart Sherry H. , Urquhart Robin 
Published: June 2022

Objectives:
Theoretical models suggest that anxiety, pain intensity, and pain catastrophizing are implicated in a cycle that leads to heightened fear of cancer recurrence (FCR). However, these relationships have not been empirically examined. The objective of this study was to examine the relationships between anxiety symptoms, pain intensity, pain catastrophizing, and FCR in childhood cancer survivors and their parents and to examine whether pain catastrophizing predicts increased FCR beyond anxiety symptoms and pain intensity.

Methods:
The participants were 54 survivors of various childhood cancers (M
age=13.1 y, range=8.4 to 17.9 y, 50% female) and their parents (94% mothers). Children reported on their pain intensity in the past 7 days. Children and parents separately completed measures of anxiety symptoms, pain catastrophizing, and FCR.

Results:
Higher anxiety symptoms were associated with increased pain intensity, pain catastrophizing, and FCR in childhood cancer survivors. Higher anxiety symptoms and pain catastrophizing, but not child pain intensity, were associated with FCR in parents. Hierarchical linear regression models revealed that pain catastrophizing explained unique variance in both parent (ΔR
2=0.11, P<0.01) and child (ΔR
2=0.07, P<0.05) FCR over and above the effects of their own anxiety symptoms and child pain.

Discussion:
The results of this study provides novel data on the association between pain and FCR and suggests that a catastrophic style of thinking about pain is more closely related to heightened FCR than one’s anxiety symptoms or the sensory pain experience in both childhood cancer survivors and their parents. Pain catastrophizing may be a novel intervention target for survivors and parents struggling with fears of recurrence.
Primary Use of the Deep Inferior Epigastric Pedicle for Free-flap Phalloplasty: Rationale, Technique, and Outcomes
Authors: Yuan Nance , Ray Edward C. , Smith Shannon , Garcia Maurice M. 
Published: June 2022

Background:
Most free-flap phalloplasty reports describe the femoral artery and great saphenous vein as recipient vessels, with the deep inferior epigastric artery and venae comitantes (DIEA/V) only rarely reported. We review our experience with preferentially using the DIEA/V as recipient vessels in gender-affirming free-flap phalloplasty, with DIEV as primary venous outflow.

Methods:
We retrospectively reviewed consecutive patients who underwent gender-affirming free-flap phalloplasty at our single institution from June 2017 through June 2021. The DIEA/V was used as recipient vessels, with the DIEA/V pedicle externalized via a passageway made through the external inguinal ring.

Results:
Thirty-eight consecutive free flaps (26 radial forearm free-flap phalloplasties, 10 anterolateral thigh phalloplasties, and two radial forearm free-flap urethroplasties) were performed. Mean age was 37.3 years; mean BMI was 25.7. Mean follow-up was 17.9 months. All flaps were anastomosed to the DIEA/V, without use of vein grafts. Most flaps (89.5%) had at least two veins anastomosed. To augment outflow, a saphenous vein branch was used in one of 38 (2.6%) cases and other superficial veins were used in two of 38 (5.3%) cases. One of 38 (2.6%) cases (early in our experience) resulted in total flap loss.

Conclusions:
Advantages of the DIEA/V as free-flap phalloplasty recipient vessels include a short, direct pathway for vessels, excellent donor-recipient vessel size match that allows end-to-end anastomoses, and elimination of risks associated with arterialized interposed veins. When venous outflow appears compromised, we recommend a low threshold to use additional local or saphenous veins, though this is rarely needed given the DIEV’s reliability.
Free Functional Muscle Transfer following Upper Extremity Sarcoma Resection: A Case Report
Authors: Bitoiu Brendon , Grigor Emma , Abdelbary Hesham , Cormier Nicholas S. , Zhang Jing 
Published: June 2022

Summary:
Functional reconstruction of the upper extremity has traditionally involved tendon transfer or pedicled muscle transfer. The gracilis free functional muscle transfer remains as an excellent option for restoration of finger flexion. Here, we provide a case report of a 35-year-old man diagnosed with left forearm high-grade epithelioid sarcoma who underwent innervated free gracilis transfer and a secondary free flap, the profunda artery perforator flap, through a single donor-site incision to expand soft tissue coverage. Postoperatively, there were no complications reported. At 8-month follow-up, the patient had Musculoskeletal Tumor Score of 22/30, and a Quick Disabilities of the Arm, Shoulder, and Hand score of 34/100.
Efficacy of Combined Phacoemulsification and Goniosynechialysis in Primary Angle Closure Disease With Different Degrees of Peripheral Anterior Synechiae
Authors: Wei Liqing , Fu Lin , Nie Li , Lian Hengli , Qian Zhenbin , Liang Yuanbo , Pan Weihua 
Published: June 2022

Précis:
Phacoemulsification and goniosynechialysis (Phaco-GSL) was equally effective in the treatment of primary angle-closure disease (PACD) with preoperative peripheral anterior synechiae (PAS) <180 degrees and larger than 180 degrees. Patients with a larger preoperative PAS range required more range of mechanical separation intraoperatively and displayed more recurrence of PAS (re-PAS) range postoperatively.

Purpose:
To evaluate the long-term efficacy of combined phaco-GSL in PACD with different extent of PAS.

Patients and Methods:
A retrospective study was conducted on 67 patients (79 eyes) who received phaco-GSL. The patients were divided into 2 groups according to the extent of PAS (group A: PAS ≤180 degrees; group B: PAS >180 degrees). Changes in intraocular pressure (IOP), the number of anti-glaucoma drugs, intraoperative mechanical separation of PAS and range of re-PAS during the last follow-up ≥12 months were analyzed.

Results:
At baseline, eyes in group B presented with higher IOP and more anti-glaucoma drugs usage (P=0.008 and 0.004). The PAS range, IOP, number of anti-glaucoma medication were reduced both in 2 groups at the final visit. The range of mechanical separation intraoperatively and re-PAS postoperatively were both larger in group B (P=0.002 and <0.001). The postoperative re-PAS range was positively correlated with the range of mechanical separation (R
2=0.17). The complete success rates at 12, 24, 36, and 48 months were 86.8%, 71.1%, 71.1%, and 71.1% in group A; and 80.5%, 74.6%, 69.9%, and 69.9% in group B. The qualified success rates were 100%, 96.6%, 92.0%, and 92.0% in group A; and 100%, 89.5%, 85.1%, and 85.1% in group B.

Conclusion:
Phaco-GSL for the treatment of PACD showed equally effective IOP control regardless of the extent of preoperative PAS.
Blood glucose responses are associated with prolonged sitting-induced changes in arterial stiffness: a randomized crossover trial
Authors: Horiuchi Masahiro , Stoner Lee 
Published: June 2022

Objective
To determine whether the vascular dysfunction response to prolonged sitting combined with hyperglycemia can be mitigated with simple and feasible sitting interruption exercises.

Methods
Twenty healthy young adults [50% women, 21 (2) years, BMI of 21.5 (1.6) kg/m2; (SD)] were enrolled in this study. This study included two 3-h prolonged sitting conditions: uninterrupted sitting (CON) and interruptions with 1-min light half-squat exercises every 20 min (EX). In both conditions, participants ingested 75-g glucose before sitting. The primary outcome was brachial-ankle pulse wave velocity (baPWV).

Results
Linear mixed-effects model analysis revealed a significant interaction effect for baPWV, with a 25% (4.7 m/s) increase for CON and a 1.3% (0.22 m/s) increase for EX. There was also an interaction effect for glucose, with a 60% (57 mg/dl) for CON and a 41% (39 mg/dl) increase for EX. Repeated measures correlation revealed a negligible association between glucose and baPWV for CON (r = −0.04) and a small association for EX (r = 0.32).

Conclusion
Vascular dysfunction occurred for the control but not the exercise condition, suggesting interrupting prolonged sitting with regular, short bouts of exercise may be an effective strategy to protect vascular health.
Displaced proximal humerus fractures treated with ORIF via the deltoid interfascicular approach vs the deltopectoral approach
Authors: Liu Bin , Wang Xinguang , Wang Chao , Jiao Zhenqing , Chen Wei 
Published: June 2022

Abstract

Background:
The purpose of this study was to evaluate the clinical outcomes and complications of displaced proximal humeral fractures treated with proximal humeral internal locking system (PHILOS) plate fixation via a deltoid interfascicular (DI) vs a deltopectoral (DP) approach.

Methods:
This prospective case-control study was conducted with patients admitted to our hospital from May 2015 to June 2018 who suffered from unilateral displaced proximal humerus fractures. Patients were treated with PHILOS plate fixation via a DI (DI group) or DP approach (DP group). The clinical outcomes and complication data were collected for comparison between the 2 groups. The patients were followed up at 3, 6, and 12 months; and every 6 months thereafter. The patients’ functional recoveries were evaluated according to the normalized Constant-Murley score, range of motion of the shoulder (flexion, abduction, external/internal rotation) and disabilities of the arm, shoulder and hand score.

Results:
A total of 77 patients, followed for an average of 15 ± 2.2months (range, 12–21), were enrolled (36 in DI group and 41 in DP group) for final analysis. No significant differences in age, sex, affected side, fracture type, injury mechanism or time from injury to operation were found between the 2 groups (all P > .05). The incision length, intra-operative blood loss, and duration of operation in the DI group were significantly less than those in the DP group, respectively (all P < .05). The functional outcomes assessed by the normalized Constant-Murley score and range of motion of flexion and internal rotation in the DI group were superior to those in the DP group at 3 and 6months after the operation (P < .05); however, no significant differences were observed at the 12-month and subsequent follow-ups (all P > .05). There was no significant difference in the range of shoulder external rotation and abduction during the postoperative follow-ups (P > .05). At the last follow-up, the mean disabilities of the arm, shoulder, and hand score was 14.0 (6.6) points in the DI group and 14.4 (6.9) points in the DP group (P = .793). Complications occurred in 1 patient in the DI group and 8 patients in the DP group (P = .049).

Conclusion:
The current study demonstrates that DI approach is a safe and effective alternative for the treatment displaced proximal humerus fractures. The DI approach rather than DP approach was recommended when lateral and posterior exposure of the proximal humerus is required, especially when fixed with PHILOS plate.
Clinical relevance of receptor conversion in metastatic breast cancer
Authors: Silva Diogo J. , Miranda Gonçalo , Mesquita Alexandra 
Published: June 2022

Abstract

Introduction:
Breast cancer comprises several different pathological entities defined by the presence or absence of hormonal receptors and human epidermal growth factor receptor 2 (HER2). During the disease course, the increase in tumor heterogeneity contributes to the discordant expression of estrogen/progesterone receptors and HER2 status between primary and metastatic lesions. We describe a case that demonstrates the clinical relevance of molecular reassessment during metastatic breast cancer progression.

Patient concerns:
A 40-year-old Caucasian woman with germline breast cancer gene mutation was referred to a general surgery appointment after breast ultrasound revealed a suspicious nodular lesion in 2012.

Diagnosis:
Ultrasound-guided microbiopsy revealed an invasive ductal carcinoma of no special type, hormone receptor-positive, and HER2-negative.

Interventions:
The patient underwent modified radical left mastectomy, adjuvant radiotherapy, chemotherapy, and endocrine therapy. Four years after the diagnosis, HER2 positive lung progression was documented, and the patient received anti-HER2 targeted systemic therapy for 15 months. New disease progression with a triple-negative profile was found, and palliative systemic treatment was changed to carboplatin for 3 months until new progression. Based on the results of the OlympiAD trial, monotherapy with Olaparib 300 mg twice daily for 28 days was initiated.

Outcomes:
After seven cycles of treatment, patient showed progressive improvement in quality of life and maintained stable disease without significant adverse events.

Conclusion:
The clinical relevance of hormone receptor and HER2 status discordance between primary tumors and metastatic lesions has been studied in recent years. This case report illustrates the clinical impact of molecular changes during disease progression and the adaptation of treatment options. This allows for an increase in both survival and quality of life in patients with metastatic breast cancer.