bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model
Authors: Le Viet‐Thang , Thuy Le Minh‐An , Nguyen Duc Hue , Tang Loc Ngoc Phuong , Pham Tuan Anh , Nguyen Anh Minh , Nguyen Minh Kien , Van Ngo Tan , Tran Thanh Trung , Van Le Tuan , Jallon Pierre , Lim Kheng‐Seang 
Published: September 2022

AbstractObjectiveAlthough epilepsy surgery is more effective than medical therapy for drug‐resistant patients, it is underutilized in both high‐income and low‐ and middle‐income countries. In light of our efforts to establish an epilepsy surgery program in a resource‐limited setting, this study aimed to determine the outcome of the epilepsy surgery program in Ho Chi Minh City (HCMC), Vietnam.MethodsIn 2018, we developed the HCMC epilepsy core multidisciplinary team with members from various hospitals and centers. The team typically included neurologists, neurosurgeons, neuropsychologists, psychiatrists, and nursing specialists. Presurgical evaluations were performed for patients with drug‐resistant epilepsy, fulfilling the ILAE criteria, with an epileptogenic lesion (mesial temporal sclerosis, low‐grade gliomas, or focal cortical dysplasia). All epilepsy surgeries were performed in two epilepsy surgery centers in HCMC between 2018 and 2021. The patients were followed up for at least 12 months.ResultsFifty‐two patients with drug‐resistant epilepsy underwent presurgical evaluation, of which 35 underwent surgery. Among the 52 patients, 20 (38.5%) underwent surgery after showing concordance among the results of standard presurgical assessments such as semiology, scalp interictal or ictal electroencephalography, and brain imaging. Among the 26 people with epilepsy who required more advanced evaluations, 15 underwent surgery with intraoperative electrocorticography to delineate the optimal resection borders. The outcomes of Engel Class I and Class II were achieved in 29/35 (82.8%) and 6/35 (17.2%) patients, respectively.SignificanceThe epilepsy surgery program with a multicentered collaborative model in a resource‐limited setting showed favorable outcomes in HCMC, Vietnam.
Geoarchaeological characterisation of a Younger Dryas site in the Alpine uplands: Cornafessa rock shelter (Italy)
Authors: Angelucci Diego E. , Patauner Erica , Duches Rossella 
Published: September 2022

AbstractThe effects of the Younger Dryas (YD) fluctuation on Late Pleistocene hunter‐gatherers' settlement and subsistence systems in the southern Alps are poorly known. This is primarily due to the scarcity of archaeological sites dating from the YD, in contrast with the extensive evidence available from the lateglacial interstadial and the early Holocene. Here, we present the initial stratigraphic, chronologic and geoarchaeological data collected from Cornafessa rock shelter, a new site located in the Lessini massif of the Italian Alps, at an elevation of 1240 m. The site was occupied during both the YD and the early Holocene. The YD archaeological deposit is clearly recognisable within the fairly uniform lateglacial and Holocene clastic succession. Geoarchaeological data indicate that the YD deposit corresponds to an occupation surface, which was formed during short visits to the site by late Epigravettian hunter‐gatherer groups, who settled in the sheltered area and performed distinct activities.
Origin of the Tudigou intrusion and associated porphyry Cu mineralization in the southern Qinling, Central China: Implication for regional tectonic setting
Authors: Zhang Zhong‐Yu , Wang Yin‐Hong , Liu Jia‐Jun , Lin Shan‐Yuan , Zhang Fang‐Fang , Bo Zhen‐Yu , Zhang Wei , Gao Jian , Li Hong‐Yu 
Published: September 2022

The Tudigou porphyry Cu deposit is located in the central part of the southern Qinling belt. Copper mineralization is closely associated with monzogranite porphyry. Zircon LA–ICP–MS U–Pb dating of monzogranite porphyry suggests that the ages of magmatism at Tudigou vary between 150 ± 1 and 148 ± 1 Ma and overlap with the molybdenite Re–Os age of 150–148 Ma, indicating that the Tudigou intrusion and associated mineralization formed during the Late Jurassic. The enrichment in large‐ion lithophile elements, depletion in high‐field‐strength elements, high Ba/Th and La/Yb ratios, and negative correlation between Dy/Yb and La/Sm ratios, together with narrow ranges of εHf(t) values (εHf(t) = −4.0 to +1.4) suggest monzogranite porphyry was derived from a metasomatized lithospheric mantle with minor crustal components contribution, which is also evidenced by the lead isotopic result. The La/Yb ratios of 30 Mesozoic plutons in the southern Qinling belt were used to calculate the Moho depth, which suggests that the magmatism and mineralization in the region occurred during lithosphere thinning in response to the tectonic transition from compression to extension transitional regime. The calculated oxygen fugacity of the Late Mesozoic porphyry deposits in the Qinling–Dabie orogen have identical ΔFMQ values (averaging +1.4 to +2.4). However, the V/Sc ratios (the proxy for water content) are distinct among different deposit sizes, indicating that the dissolved water in the magma plays a critical role in porphyry‐type mineralization.
Potential beneficial effects of masupirdine (SUVN‐502) on agitation/aggression and psychosis in patients with moderate Alzheimer's disease: Exploratory post hoc analyses
Authors: Nirogi Ramakrishna , Jayarajan Pradeep , Benade Vijay , Shinde Anil , Goyal Vinod Kumar , Jetta Satish , Ravula Jyothsna , Abraham Renny , Grandhi Venkata Ramalingayya , Subramanian Ramkumar , Pandey Santosh Kumar , Badange Rajesh Kumar , Mohammed Abdul Rasheed , Jasti Venkat , Ballard Clive , Cummings Jeffrey 
Published: September 2022

AbstractObjectivesThe effects of masupirdine on the neuropsychiatric symptoms were explored.MethodsMasupirdine (SUVN‐502) was evaluated for its effects on cognition in patients with moderate AD. The prespecified primary outcome showed no drug‐placebo difference. Post hoc analyses of domains of the 12‐item neuropsychiatric inventory scale were carried out.ResultsIn a subgroup of patients (placebo, n = 57; masupirdine 50 mg, n = 53; masupirdine 100 mg, n = 48) with baseline agitation/aggression symptoms ≥1, a statistically significant reduction in agitation/aggression scores was observed in masupirdine 50 mg (95% confidence interval (CI), −1.9 to −0.5, p < 0.001) and masupirdine 100 mg (95% CI, −1.7 to −0.3, p = 0.007) treated arms at Week 13 in comparison to placebo and the effect was sustained for trial duration of 26 weeks in the masupirdine 50 mg treatment arm (95% CI, −2.3 to −0.8, p < 0.001). Similar observations were noted in the subgroup of patients (placebo, n = 29; masupirdine 50 mg, n = 30; masupirdine 100 mg, n = 21) with baseline agitation/aggression symptoms ≥3. In the subgroup of patients (placebo, n = 28; masupirdine 50 mg, n = 28; masupirdine 100 mg, n = 28) who had baseline psychosis symptoms and/or symptom emergence, a significant reduction in psychosis scores was observed in the masupirdine 50 mg (Week 4: 95% CI, −2.8 to −1.4, p < 0.001; Week 13: 95% CI, −3.3 to −1.3, p < 0.001) and masupirdine 100 mg (Week 4: 95% CI, −1.4 to 0, p = 0.046; Week 13: 95% CI, −1.9 to 0.1, p = 0.073) treatment arms in comparison to placebo.ConclusionFurther research is warranted to explore the potential beneficial effects of masupirdine on NPS.
Evaluating the implementation of user embracement in the healthcare system of Jaboatão dos Guararapes city, Brazil
Authors: de Lima Barros Litian Oliveira , Nunes Diniz George Tadeu , Silva Fabiana Brito , de Araújo Oliveira Sydia Rosana 
Published: September 2022

AbstractBackgroundThe advent of the Family Health Strategy required healthcare teams to strengthen bonding and accountability towards users. In this sense, humanisation has been the key to a successful care provision and to the acceptance of interventions that can meet demands. Our study aimed to evaluate the implementation of user embracement in Family Health Units of Jaboatão dos Guararapes, Pernambuco, Brazil.MethodsThe studied population belonged to 48 Family Health teams. Eighty‐five healthcare workers with higher education answered the questionnaire, and the registration forms of 272 users were examined, from which sociodemographic information was gathered. These data were analysed according to the degree of vulnerability. Questionnaire results were collected and tabulated using the HCMaps software. Dimensions were analysed through a Likert‐type grading scale ranging from 1 to 5. This is an evaluative, cross‐sectional study with a quantitative approach, considering the dimensions proposed in the RE‐AIM framework.ResultsUser embracement was considered unsatisfactory, as were Reach and Adoption. The Effectiveness, Implementation, and Maintenance dimensions yielded satisfactory results. The main ones were the perception of user embracement as a screening process, and the delimitation of open slots and/or schedules.ConclusionsThe study shows that user embracement has been effective in strengthening bonds, reducing queues, and solving demands. However, the potential user embracement sustainability and implementation have been hampered by factors related to the Adoption of the intervention.
Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward
Authors: Cavalier Haleigh , Trasande Leonardo , Porta Miquel 
Published: September 2022

AbstractKnowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high‐quality prospective studies and those using biomarkers for exposure assessment, with some observing dose‐response relationships. Though high‐quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi‐omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population‐based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.
Competition, stability, and institutional environment: The case of dual banking economies
Authors: Azmi Wajahat , Anwer Zaheer , Ali Mohsin , Mohamad Shamsher 
Published: September 2022

AbstractWe measure the impact of competition and institutional quality on stability for dual banking economies. Our sample comprises 492 banks (109 Islamic and 383 conventional banks) from 17 countries with dual‐banking systems. The sample period is from 2005 to 2020. The estimations are performed using Two Step System Generalized Method of Moments approach. Our findings reveal heterogeneous effect of competition on stability. We found the evidence of competition‐stability paradigm in case of full sample as well as for Islamic banks. There is no effect of competition on the stability of conventional banks. Furthermore, there is no evidence of size effect in the competition‐stability results. The impact of legal institution is insignificant. We also observe that better quality of political and the economic institutions increases the bank stability. We attribute these findings to the conjecture that better political and/or legal institutions improve bank stability by reducing information asymmetry and adverse selection. Finally, we find the evidence that political, legal and economic dimensions of institutions have differential effect on competition‐stability relationship. The findings are robust to alternative definitions of competition, stability and different methodological approaches.
The resource reallocation effect of monetary policy
Authors: Zhang Jiarui , Shi Yingying 
Published: September 2022

AbstractThis paper studies the heterogeneous responses of firms to monetary policy shocks and the possible adverse effect of expansionary monetary policy on resource reallocation. Using Chinese firm‐level data, we find that when expansionary monetary shock hits the economy, less productive firms are more responsive than productive firms in terms of resource accumulation. We identify two mechanisms for this effect. First, less productive firms accumulate net worth more slowly. They have higher leverage ratio and are more sensitive to monetary policy changes (the intensive margin). Second, monetary expansion relaxes borrowing constraints, which enables unproductive firms to survive. The congestion effect prevents resources from allocating to more productive firms. Our finding is robust even if we use private firm subsamples or avoid the massive fiscal stimulus in China around 2009. We provide a simple model of firm dynamics to capture these effects.
A lightweight deep learning model for retinal optical coherence tomography image classification
Authors: Mathews Mili Rosline , Anzar Sharafudeen Thaha Mohammed 
Published: September 2022

AbstractAutomated retinal disease detection and grading is one of the most researched areas in medical image analysis. In recent years, Deep Learning models have attracted much attention in this field. Hence, in this paper, we present a Deep Learning‐based, lightweight, fully automated end‐to‐end diagnostic system for the detection of the two major retinal diseases, namely diabetic macular oedema (DME) and drusen macular degeneration (DMD). Early detection of these diseases is important to prevent vision impairment. Optical coherence tomography (OCT) is the main imaging technique for detecting these diseases. The model proposed in this work is based on residual blocks and channel attention modules. The performance of the model is evaluated using the publicly available Mendeley OCT dataset and the Duke dataset. We were able to achieve a classification accuracy of 99.5% in the Mendeley test dataset and 94.9% in the Duke dataset with the proposed model. For the application, we performed an extensive evaluation of pre‐trained models (LeNet, AlexNet, VGG‐16, ResNet50 and SE‐ResNet). The proposed model has a much smaller number of trainable parameters and shows superior performance compared to existing methods.
A multimethod examination of hope and adolescent STEM career expectancies
Authors: Alexander Brittany L. , Janssen Jayley , Fraser Ashely M. , Bryce Crystal I. , Fabes Richard A. 
Published: September 2022

AbstractIntroductionScience, technology, engineering, and mathematics (STEM) fields are growing rapidly and understanding adolescent's interest and hope for pursuing a STEM career is essential for additional growth and opportunity collectively and individually. Hope is a cognitive–motivational construct that includes three components: hopeful future expectations (HFEs), intentional self‐regulation (ISR), and connection, and is associated with academic achievement and career pursuit; it has not been examined in relation to STEM. This study fills a gap in the literature by taking a multimethod approach to understanding the association between adolescents' hope and STEM career interests.MethodsParticipants were 639 middle‐ and high‐school adolescents in the southwestern United States who quantitatively reported their hope and STEM career interests and provided qualitative descriptions of reasons for wanting to pursue a STEM career.ResultsQuantitatively, HFEs significantly and positively predicted STEM career interest. Relations were examined by gender and school level. For middle‐school girls, ISR significantly predicted STEM career interest, for middle‐school boys and high‐school girls, HFEs positively significantly predicted STEM career interest, but results of high‐school boys were nonsignificant. Qualitatively, adolescents mentioned reasons aligning with HFEs and ISR as motivations for pursuing a STEM career, as well as prosocial motivations. Additionally, they discussed their interest in a STEM career as a way to pursue other goals such as financial stability.DiscussionFindings highlight the possibility of hope as a malleable motivation for STEM career pursuit. Our findings support the components of hope as a salient associate of early STEM career interest, with adolescents who have high HFEs and ISR being particularly apt to say they would like to pursue a STEM career. Our results support the active development of hope among US adolescents as a catalyst toward personal and global success.
A computational approach for modeling electronic circular dichroism of solvated chromophores
Authors: Monti Marta , Stener Mauro , Aschi Massimiliano 
Published: September 2022

AbstractThe present study consists in a novel computational protocol to model the UV‐circular dichroism spectra of solvated species. It makes use of quantum‐chemical calculations on a series of conformations of a flexible chromophore or on a series of chromophore/solvent clusters extracted from molecular dynamic simulations. The protocol is described and applied to the aqueous cationic tripeptide GAG+ and to the aqueous neutral decapeptide (GVGVP)2. The protocol has proven able to: (i) properly consider the conformational motion of solute in the given environment; (ii) give the actual statistical weight of each conformational state; (iii) provide a reliable quantum mechanical method able to reproduce the spectral features. Temperature effects on conformations and spectral properties are properly taken into account. The role of explicit solvent on the conformational analysis and the spectra calculation is discussed. The comparison of the calculated circular dichroism spectra with experimental ones recorded at different temperatures represents a strict validation test of the method.
Integrated chemo‐ and biocatalytic processes: a new fashion toward renewable chemicals production from lignocellulosic biomass
Authors: Chen Zhu , Wang Yuguang , Cheng Haina , Zhou Hongbo 
Published: September 2022

AbstractConcerns over climate change and environmental pollution resulting from petroleum refining has spurred the exploitation of green replacements for producing chemicals and fuels. Valorization of lignocellulosic biomass into chemicals represents a promising alternative to petroleum refining. Biological and chemical catalysis are two leading routes for lignocellulose variolization, but strategies relying simply on biological or chemical conversion have shown limitations. Integrating biocatalysts with chemocatalysts could leverage the inherent strengths of both while circumventing their respective disadvantages, benefiting product yield and selectivity, and reducing cost and waste generation. This review focuses on the coupled chemocatalytic and biocatalytic synthesis of renewable chemicals from polysaccharides and their derived platform chemicals. In addition, strategies for producing value‐added products from lignin via integrated chemical depolymerization and biological conversion are highlighted. The techno‐economics of integrating chemocatalysts and biocatalysts in producing chemicals in the context of biorefinery are also discussed. Finally, perspectives on designing integrated chemical and biological catalysis for renewable chemicals production are provided. © 2022 Society of Chemical Industry (SCI).
Altered neurovascular coupling in thyroid‐associated ophthalmopathy: A combined resting‐state fMRI and arterial spin labeling study
Authors: Chen Wen , Hu Hao , Chen Huan‐Huan , Liu Hu , Wu Qian , Chen Lu , Zhou Jiang , Jiang Wen‐Hao , Xu Xiao‐Quan , Wu Fei‐Yun 
Published: September 2022

AbstractBesides the well‐documented ophthalmic manifestations, thyroid‐associated ophthalmopathy (TAO) is believed to be related to emotional and psychological abnormalities. Given the previous neuroimaging evidence, we hypothesized that TAO patients would have altered neurovascular coupling associated with clinical‐psychiatric disturbances. This study was to investigate neurovascular coupling changes in TAO by combining resting‐state functional magnetic resonance imaging (rs‐fMRI) and arterial spin labeling (ASL) techniques. Amplitude of low‐frequency fluctuation (ALFF) was calculated from rs‐fMRI, and cerebral blood flow (CBF) was computed from ASL in 37 TAO patients and 21 healthy controls (HCs). Global neurovascular coupling was assessed by across‐voxel CBF‐ALFF correlation, and regional neurovascular coupling was evaluated by CBF/ALFF ratio. Auxiliary analyses were performed using fractional ALFF (fALFF) and regional homogeneity (ReHo) as rs‐fMRI measures. Compared with HCs, TAO patients showed significantly reduced global CBF‐ALFF coupling. Moreover, TAO patients exhibited decreased CBF/ALFF ratio in the left lingual gyrus (LG)/fusiform gyrus (FFG), and increased CBF/ALFF ratio in the bilateral precuneus (PCu). In TAOs, CBF/ALFF ratio in the left LG/FFG was positively correlated with visual acuity, while CBF/ALFF ratio in the bilateral PCu was negatively correlated with Montreal Cognitive Assessment score. The auxiliary analyses showed trends of reduced global neurovascular coupling (i.e., CBF‐fALFF correlation and CBF‐ReHo correlation), as well as significant altered regional neurovascular coupling (i.e., CBF/fALFF ratio and CBF/ReHo ratio) in several brain regions. These findings indicated that TAO patients had altered neurovascular coupling in the visual and higher‐order cognitive cortices. The neurovascular decoupling might be a possible neuropathological mechanism of TAO.
Molecular examination of the endogenous opioid system in rhesus macaque monkeys with self‐injurious behavior
Authors: Jackson Marques , Foret Brittany L. , Fontenot Jane , Hasselschwert Dana , Smith Josh , Romero Emily , Smith Karen Müller 
Published: September 2022

AbstractSelf‐injurious behavior (SIB) can lead to serious injury and occurs in approximately 1%–4% of the adult population, with higher incidences in adolescent and institutionalized populations, as well as in children with developmental disorders such as Autism. SIB also spontaneously occurs in a low percentage of captive monkeys. Rhesus macaque (Macaca mulatta) monkeys are evolutionarily and physiologically similar to humans, share 93% genetic sequence similarity to humans, and have long been used as testing subjects for vaccine and clinical trials. Previous studies hypothesized that altered endogenous opioid expression occurs in the brains of individuals and animals that self‐injure. We examined the regional mRNA expression of opioid signaling genes in sixteen rhesus macaques that exhibited SIB and eight sex‐ and age‐ matched controls. The brain regions examined are linked to reward reinforcement and stress adaptation including the hypothalamus, orbital frontal cortex, nucleus accumbens, hippocampus, caudate, and the amygdala. We found decreased μ‐opioid receptor (OPRM1) in the amygdala of monkeys with SIB, and reduced prodynorphin (PDYN) in the hypothalamus. Our data suggest dysfunction in the regulation of opioid peptide precursors and calls for further investigation of the endogenous opioid system in SIB.