bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of timely complementary feeding initiation and associated factors among mothers having children aged 6–24 months in rural north-central Ethiopia: Community based cross-sectional study
Authors: Abate Moges Wubneh , Nigat Adane Birhanu , Demelash Agimasie Tigabu , Emiru Tigabu Desie , Tibebu Nigusie Selomon , Tiruneh Chalie Marew , Belete Amsalu , Abebe Tilahun Kegne , Yitayew Moges Yinges 
Published: May 2022

Background
Complementary foods are defined as any solid or liquid foods other than breast milk offered to children. Timely initiation of complementary foods during infancy is necessary for growth and development. The first two years of life are important period for rapid physical, cognitive and social development that requires optimal nutrition. Currently, there is no study done in this rural community about timely initiation of complementary feeding.

Objective
The main aim of this study was to assess the prevalence of timely initiation of complementary feeding among mothers having children aged 6–24 months in Farta district, rural Ethiopia.

Methods
A community-based cross-sectional study was employed from December 2020 to February 2021 among 570 mothers by using multi-stage sampling techniques. Data were collected using a structured interviewer-administered questionnaire and entered into Epi Data 4.6 then transferred to Statistical Package for Social Science version 25 for analysis. Bivariate and multivariable logistic regression analysis with a 95% confidence interval carried out to determine the association between explanatory and the outcome variables. A P-value of < 0.05 was considered statistically significant.

Results
The prevalence of timely initiation of complementary feeding among mothers having children aged 6–24 months was 51.9%. Institutionaldelivery [(AOR = 2.10, 95% CI: (1.31–3.32)],Keeping livestock [(AOR = 2.21, 95% CI: (1.35, 3.65)], Postnatal follow up [(AOR = 0.60, 95% CI:(0.36, 0.77)],merchants [(AOR = 4.58; 95% CI:1.99, 10.55)], and daily labourer [(AOR = 2.88, 95% CI:(1.50–5.51)] were statistically associated with timely initiation of complementary feeding.

Conclusion
This finding revealed that the prevalence of timely initiation of complementary feeding is still low. Factors affecting timely initiations of complementary feeding were home delivery, unable to attend postnatal care follow-up, being housewife and farmers. All health professionals including health extension workers should give special attention to advising and counseling for mothers and their husbands about timely initiation of complementary feeding.
Risk factors and economic burden of postoperative anastomotic leakage related events in patients who underwent surgeries for colorectal cancer
Authors: Kang Jeonghyun , Kim Hyesung , Park HyeJin , Lee Bora , Lee Kang Young 
Published: May 2022

Background
Nationwide research about the clinical and economic burden caused by anastomotic leakage (AL) has not been published yet in Korea. This study assessed the AL rate and quantified the economic burden using the nationwide database.

Methods
This real world evidence study used health claims data provided by the Korean Health Insurance Review and Assessment Service (HIRA, which showed that 156,545 patients underwent anterior resection (AR), low anterior resection (LAR), or ultra-low anterior resection (uLAR) for colorectal cancer (CRC) between January 1, 2007 and January 31, 2020. The incidence of AL was identified using a composite operational definition, a composite of imaging study, antibacterial drug use, reoperation, or image-guided percutaneous drainage. Total hospital costs and length of stay (LOS) were evaluated in patients with AL versus those without AL during index hospitalization and within 30 days after the surgery.

Results
Among 120,245 patients who met the eligibility criteria, 7,194 (5.98%) patients had AL within 30 days after surgery. Male gender, comorbidities (diabetes, metastatic disease, ischemic heart disease, ischemic stroke), protective ostomy, and multiple linear stapler use, blood transfusion, and urinary tract injury were associated with the higher odds of AL. Older age, rectosigmoid junction cancer, AR, LAR, and laparoscopic approach were related with the reduced odds of AL. Patients with AL incurred higher costs for index hospitalization compared to those without AL (8,991 vs. 7,153 USD; p<0.0001). Patients with AL also required longer LOS (16.78 vs. 14.22 days; p<0.0001) and readmissions (20.83 vs. 13.93 days; p<0.0001).

Conclusion
Among patients requiring resection for CRC, the occurrence of AL was associated with significantly increased costs and LOS. Preventing AL could not only produce superior clinical outcomes, but also reduce the economic burden for patients and payers.
COVID-19 vaccine acceptance among health care workers in Africa: A systematic review and meta-analysis
Authors: Ackah Martin , Ameyaw Louise , Gazali Salifu Mohammed , Afi Asubonteng Delali Pearl , Osei Yeboah Cynthia , Narkotey Annor Eugene , Abena Kwartemaa Ankapong Eunice , Boakye Hosea 
Published: May 2022

IntroductionCoronavirus Disease (COVID-19) vaccine acceptance, and hesitancy amongst Health Care Workers (HCWs) on the African continent have been examined through observational studies. However, there are currently no comprehensive reviews among these cadre of population in Africa. Hence, we aimed to review the acceptance rate and possible reasons for COVID-19 vaccine non-acceptance/hesitancy amongst HCWs in Africa.MethodsWe searched Medline/PubMed, Google Scholar, and Africa Journal Online from January, 2020 to September, 2021. The Newcastle-Ottawa Quality Assessment tool adapted for cross-sectional studies was used to assess the quality of the retrieved studies. DerSimonian and Laird random-effects model was used to pool the COVID-19 vaccine acceptance rate. Sub-group and sensitivity analyses were performed. Reasons for COVID-19 vaccine hesitancy were also systematically analyzed.ResultsTwenty-one (21) studies were found to be eligible for review out of the 513 initial records. The estimated pooled COVID-19 vaccine acceptance rate was 46% [95% CI: 37%-54%]. The pooled estimated COVID-19 vaccine acceptance rate was 37% [95% CI: 27%-47%] in North Africa, 28% [95% CI: 20%-36%] in Central Africa, 48% [CI: 38%-58%] in West Africa, 49% [95% CI: 30%-69%] in East Africa, and 90% [CI: 85%-96%] in Southern Africa. The estimated pooled vaccine acceptance was 48% [95% CI:38%-57%] for healthcare workers, and 34% [95% CI:29%-39%] for the healthcare students. Major drivers and reasons were the side effects of the vaccine, vaccine’s safety, efficacy and effectiveness, short duration of the clinical trials, COVID-19 infections, limited information, and social trust.ConclusionThe data revealed generally low acceptance of the vaccine amongst HCWs across Africa. The side effects of the vaccine, vaccine’s safety, efficacy and effectiveness, short duration of the clinical trials, COVID-19 infections, limited information, and social trust were the major reasons for COVID-19 hesitancy in Africa. The misconceptions and barriers to COVID-19 vaccine acceptance amongst HCWs must be addressed as soon as possible in the continent to boost COVID-19 vaccination rates in Africa.
METHOD AND PRINCIPLE OF MARITIME BOUNDARY DELIMITATION BETWEEN STATES WITH OPPOSITE OR ADJACENT COASTS (CASE OF INDONESIA AND TIMOR-LESTE)
Authors: Jaya Belardo Prasetya Mega , Cahyani Ferina Ardhi , Idris Idris , Permata Rika Ratna 
Published: May 2022

In the practice the maritime boundary delimitations can cause the overlap of claims between states with opposite or adjacent coasts. Regarding the maritime boundary between Indonesia and Timor-Leste, there was never a maritime boundary between both States, so it needs a settlement of disputes of maritime boundary delimitation between both parties. Therefore, these research aims to explain the methods and principles that could be used in resolving maritime boundary delimitation dispute between state with opposite or adjacent coasts based on international law and analyze how obstacles and solution to solve maritime boundary delimitation dispute between Indonesia and Timor-Leste (East Timor). This research uses normative legal research and Empirical Research Methods. The results of the research show that: (1) the maritime boundary delimitation between Indonesia and Timor-Leste uses enclaving, equidistant, and three-step approach method. (2), Indonesia and Timor Leste have the potential to determine maritime boundaries in the three areas, namely the area to the north of the Oecusse (Ombai Strait), to the north of Timor Island (Wetar Strait) and to the south of Timor Island (Timor Sea). Timor-Leste will still get a maritime territory in District Oecusse but the extent would be negotiated with Indonesia first, while in the Wetar Strait, the territorial sea division of the two countries would consider the outer islands of both countries.
Hippo
Authors: Shin Ahnjae , Jeong Joo Seong , Kim Do Yoon , Jung Soyoung , Chun Byung-Gon 
Published: May 2022

Hyper-parameter optimization is crucial for pushing the accuracy of a deep learning model to its limits. However, a hyper-parameter optimization job, referred to as a study, involves numerous trials of training a model using different training knobs, and therefore is very computation-heavy, typically taking hours and days to finish.
We observe that trials issued from hyper-parameter optimization algorithms often share common hyper-parameter sequence prefixes. Based on this observation, we propose Hippo, a hyper-parameter optimization system that reuses computation across trials to reduce the overall amount of computation significantly. Instead of treating each trial independently as in existing hyper-parameter optimization systems, Hippo breaks down the hyper-parameter sequences into stages and merges common stages to form a tree of stages (a stage tree). Hippo maintains an internal data structure, search plan, to manage the current status and history of a study, and employs a critical path based scheduler to minimize the overall study completion time. Hippo applies to not only single studies but multi-study scenarios as well. Evaluations show that Hippo's stage-based execution strategy outperforms trial-based methods for several models and hyper-parameter optimization algorithms, reducing end-to-end training time by up to 2.76X (3.53x) and GPU-hours by up to 4.81X (6.77x), for single (multiple) studies.
Right ventricular myocardial energetic model for evaluating right heart function in pulmonary arterial hypertension
Authors: Scott Jacqueline V. , Tembulkar Tanuf U. , Lee Meng‐Lin , Faliks Bradley T. , Koch Kelly L. , Vonk‐Noordegraaf Anton , Cook Keith E. 
Published: May 2022

AbstractBackgroundPulmonary arterial hypertension (PAH) increases right ventricular (RV) workload and decreases myocardial oxygen reserve, eventually leading to poor cardiac output. This study created and assessed a novel model of RV work output based on RV hemodynamics and oxygen supply, allowing new insight into causal mechanisms of RV dysfunction.MethodsThe RV function model was built upon an earlier, left ventricular model and further adjusted for more accurate clinical use. The model assumes that RV total power output (1) is the sum of isovolumic and stroke power and (2) is linearly related to its right coronary artery oxygen supply. Thus, when right coronary artery flow is limited or isovolumic power is elevated, less energy is available for producing cardiac output. The original and adjusted models were validated via data from patients with idiopathic PAH (n = 14) and large animals (n = 6) that underwent acute pulmonary banding with or without hypoxia.ResultsBoth models demonstrated strong, significant correlations between RV oxygen consumption rate and RV total power output for PAH patients (original model, R2 = 0.66; adjusted model, R2 = 0.78) and sheep (original, R2 = 0.85; adjusted, R2 = 0.86). Furthermore, the models demonstrate a significant inverse relationship between required oxygen consumption and RV efficiency (stroke power/total power) (p < 0.001). Lastly, higher NYHA class was indicative of lower RV efficiency and higher oxygen consumption (p = 0.013).ConclusionRight ventricular total power output can be accurately estimated directly from pulmonary hemodynamics and right coronary perfusion during PAH. This model highlights the increased vulnerability of PAH patients with compromised right coronary flow coupled with high afterload.
SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel
Authors: Wu Tongde , Goriounova Alexandra S. , Worthington Erin N. , Wrennall Joe A. , Ghosh Arunava , Ahmad Saira , Flori Sassano M. , Tarran Robert 
Published: May 2022

AbstractOrai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway smooth muscle (ASM). During SOCE, Ca2+ leaves the endoplasmic reticulum, which then stimulates a second, amplifying wave of Ca2+ influx through Orai1 into the cytoplasm. Short Palate LUng and Nasal epithelial Clone 1 (SPLUNC1; gene name BPIFA1) is a multi‐functional, innate defense protein that is highly abundant in the lung. We have previously reported that SPLUNC1 was secreted from epithelia, where it bound to and inhibited Orai1, leading to reduced SOCE and ASM relaxation. However, the underlying mechanism of action is unknown. Here, we probed the SPLUNC1‐Orai1 interactions in ASM and HEK293T cells using biochemical and imaging techniques. We observed that SPLUNC1 caused a conformational change in Orai1, as measured using Forster resonance energy transfer (FRET). SPLUNC1 binding also led to Nedd4‐2 dependent ubiquitination of Orai1. Moreover, SPLUNC1 internalized Orai1 to lysosomes, leading to Orai1 degradation. Thus, we conclude that SPLUNC1 is an allosteric regulator of Orai1. Our data indicate that SPLUNC1‐mediated Orai1 inhibition could be utilized as a therapeutic strategy to reduce SOCE.
Evaluation of 18 quality indicators from the external quality assurance preanalytical programme of the Spanish Society of Laboratory Medicine (SEQCML)
Authors: Caballero Andrea , Gómez-Rioja Rubén , Ventura Montserrat , Llopis María Antonia , Bauça Josep Miquel , Gómez-Gómez Carolina , Marzana Itziar , Ibarz Mercedes 
Published: May 2022

Abstract

Objectives
Most errors in laboratory medicine occur in the pre- and post-analytical phases of the total testing process (TTP). In 2014, the Spanish Society of Laboratory Medicine (SEQCML) started the current Preanalytical Phase EQA Programme, with the objective of providing a tool for the improvement of the preanalytical phase. The aim of this study was to review the evolution of quality indicators (QI) and the comparability of established performance specifications (PS) with other EQA programmes.

Methods
In the SEQCML programme, participants were asked to register rejections of the main specimens and the causes for rejections. Data collected from 2014 to 2017, and then reviewed biennially (2018–2019), was used to calculate the percentiles; p25, p50, p75, and p90 for every round, and their means were set as PS. These PS were compared with the results of other programmes.

Results
The evolution of QI results for 2018–2019 period showed general maintenance or improvement, e.g., a significant decrease in the number of serum samples with a haemolytic index ≥0.5 g/L, except for EDTA and citrate samples handle, maybe for an improvement in detection. The comparison with PS for the QI of the IFCC Working Group “Laboratory Errors and Patient Safety” and the Key Incident Management and Monitoring System (KIMMS) programme of the RCPA showed comparable results, supporting the validity of the established specifications.

Conclusions
The PS obtained are a helpful tool for benchmarking and to identify processes of the preanalytical phase whose improvement should be set as a priority.
Genome-wide identification and expression analysis of CPP-like gene family in Triticum aestivum L. under different hormone and stress conditions
Authors: Ullah Uzair , Buttar Zeeshan Ali , Shalmani Abdullah , Muhammad Izhar , Ud-Din Aziz , Ali Hamid 
Published: May 2022

Abstract
The CPP-like plant‐specific transcription factor has a prominent role in plant development and growth through cell division and differential activities. However, little information is available about the CPP gene family in Triticum aestivum L. Herein, we identified 37 and 11 CPP genes in the wheat and rice genome databases, respectively. The phylogeny of the CPP protein-like family members was further divided into five subfamilies based on structural similarities and phenotypic functional diversities. The in silico expression analysis showed that CPP genes are highly expressed in some tissues, such as shoot apex, shoot, leaf, leaf sheath, and microspore. Furthermore, the qRT-PCR found higher expression for TaCPP gene family members in leaf, leaf blade, young spike, mature spike, and differential expression patterns under abiotic stresses, including heat, drought, salt, and hormonal treatment, such as indole acetic acid and 1-aminocyclopropane-1 carboxylic acid. We found that CPP gene family members are mostly located in the nucleus after infiltrating the CPP5-1B-GFP and TaCPP11-3B-GFP into tobacco leaves. The overexpression of the TaCPP5-1D gene revealed that the CPP gene positively regulates the germanium, shoot, and root activities in Arabidopsis. The TaCPP5-1D-overexpressed plants showed less anti-oxidative sensitivity under drought stress conditions. These results demonstrated that TaCPP5-1D protein has a crucial contribution by interacting with TaCPP11-3B protein in maintaining stress homeostasis under the natural and unfavorable environmental conditions for growth, development, and stress resistance activities. Therefore, this study could be used as pioneer knowledge to further investigate the function of CPP genes in plant growth and development.
Effect of microbial-induced calcite precipitation (MICP) on the strength of soil contaminated with lead nitrate
Authors: Hadi Zahraa Samer , Saeed Khitam Abdulhussein 
Published: May 2022

Abstract
Microbial induced calcite precipitation method MICP is a sustainable and eco-friendly technique for soil stabilization. To show the optimum effectiveness of the bioremediation within the silty sand matrix, a model of plastic boxes and PVC molds was made with an air pump placed in an isolated room at a temperature range of 25–27°C. The molds were perforated from sides and bottoms and opened from the top with a transparent film of filter paper (placed on the inner surface). The major feature of this treatment system is allowing the cementation solution to penetrate easily into soil samples. The results showed a positive effect of Bacillus subtilis in enhancing the strength properties of lead contaminated soil. Unconfined compressive strength increased from 65 kPa to 539, 527, and 525 kPa. Cohesion increased from 4.5 to 40, 41.9, and 42 kPa at concentrations of 15, 20, and 25% respectively. Angle of internal friction increased from 18.94° to 38.2°, 40°, and 40.74° respectively after 14 days. Thereafter, it become 40.92° and 41.5° at concentrations of 15 and 20%, respectively and decreased to 36.75° of 25% at 28 days. Microstructural characteristics represent the formation of calcium carbonate and lead compounds, which were the reasons for the improvement in the strength and the alteration in lead from a soluble to insoluble form, a hence less toxic element.
From garbage to COVID-19: theorizing ‘Multilingual Commanding Urgency’ in the linguistic landscape
Authors: Chesnut Michael , Curran Nathaniel Ming , Kim Sungwoo 
Published: May 2022

AbstractAcross the globe signage which conveys directives regarding appropriate behavior in public, such as ‘Do Not Enter’ signs, is made multilingual in ways that other signage is not. This paper examines two examples of multilingualism in directive signs within Seoul, South Korea in order to theorize what gives rise to multilingualism in directive signage while other signage remains monolingual. Examination of Vietnamese and Arabic on signs prohibiting the illegal disposal of household garbage on side streets in Seoul, and English, Chinese, and Japanese on mask-required due to COVID-19 signs within the Seoul subway system allows for a robust analysis of what shapes the inclusion of additional languages on directive signage. We posit the construction of a differently speaking other who is seen as likely to disobey stated regulations alongside the desire by authorities to minimize the effort required to respond to rule breaking results in amultilingual commanding urgencythat shapes multilingualism in directive signage. The concept of multilingual commanding urgency emphasizes the role enforcement practices have in shaping multilingualism, an important development in understanding this form of signage. Multilingual commanding urgency is especially relevant as it shapes signage deployed in emergency contexts such as the COVID-19 pandemic.
Impact of Oil Price Shocks on MENA Countries Stock Markets: Event Study Methodology
Authors: Benbachir Saad , Harit Satt , Chraibi Assya 
Published: May 2022

Abstract
The purpose of this paper is to examine the linkage between a sample of six oil-importing and oil-exporting MENA countries and oil price shocks over the period 2002–2020. The event study methodology is used to examine the behavior of stock prices around an event to measure its value under the efficient market theory. The findings suggest that the dataset used and the results are robust proven by overall statistically significant results for the eight events considered. The 2008 global financial crisis had the largest impact on stock markets on the event day. The nature and duration of response are also found to vary across different events and countries. Thus the practical implications of this paper are to suggest that investors should learn to better assess oil shocks by taking into account differences in country specific policies, government effectiveness and monetary policy.
Semiotics of humor in Nigerian politics
Authors: Adegoju Adeyemi 
Published: May 2022

AbstractThis study explores the semiotics of humor and political disaffection in the online feedback discourse evaluating party performance in a post-election era in Nigeria’s democratic practice. It examines the incongruities in multimodal digital humor as semiotic resources of subversive play to criticize a political party for its perceived weak program-to-policy linkage. Data for the study comprise some purposively sampled political internet memes which were deployed to express political disaffection at the party All Progressives Congress (APC) in the first half (2016–2017) of its four-year (2015–2019) tenure. The study applies Algirdas J. Greimas’ semiotic theory by drawing upon the notions of narrativity and modalities to read the selected political internet memes, which run profound social commentaries on the anxieties and frustrations of the ordinary citizens in a failing economy, thereby underpinning the thrust of the theory, which lies not only in the signification of texts but also in the signification of the living experience. The study reveals the power of signs evidenced in the deployment of objects, behaviors, practices, images, and symbols within the socio-economic sub/culture of the production of the internet memes to configure backlashes of democratic deficits relating largely to worsening poverty, hunger, struggle for survival, and political cynicism in an emerging democracy.