bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence Supports the Validity and Reliability of Response Times from a Brief Survey as a Digital Biomarker for Processing Speed in a Large Panel Study
Authors: Hernandez Raymond , Stone Arthur A , Zelinski Elizabeth , Meijer Erik , Galama Titus , Faul Jessica , Kapteyn Arie , Junghaenel Doerte U , Jin Haomiao , Gatz Margaret , Lee Pey-Jiuan , Maupin Daniel , Gao Hongxin , Orriens Bart , Schneider Stefan 
Published: January 2025

Abstract
Survey response times (RTs) have hitherto untapped potential to allow researchers to gain more detailed insights into the cognitive performance of participants in online panel studies. We examined if RTs recorded from a brief online survey could serve as a digital biomarker for processing speed. Data from 9,893 adults enrolled in the nationally representative Understanding America Study were used in the analyses. Hypotheses included that people’s average survey RTs would have a large correlation with an established processing speed test, small to moderate correlations with other cognitive tests, and associations with functional impairment. We also hypothesized that survey RTs would have sensitivity to various participant characteristics comparable to the established processing speed test’s sensitivity (e.g., similar standardized means by gender). Overall, results support the validity and reliability of people’s average RTs to survey items as a digital biomarker for processing speed. The correlation between survey RTs (reverse scored) and the formal processing speed test was 0.61 (p&lt;0.001), and small to moderate associations with most other cognitive and functional status measures were observed. Sensitivity of survey RTs to various participant characteristics was nearly identical to the formal processing speed test. Survey RTs may be useful as proxies for processing speed.
Trends in use of tobacco and cannabis across different alcohol consumption levels in the United States, 2010–19
Authors: Pham Huyen , Bui Thanh C , Glass Joseph E , Back Sudie E , Le Phuc 
Published: January 2025

Abstract

Aims
People often drink alcohol and use other substances concurrently, increasing the risk of adverse health outcomes. Our aims were to: (i) assess temporal trends in tobacco and/or cannabis use by varying alcohol consumption levels and (ii) identify associated factors of polysubstance use in high-risk alcohol users.

Methods
We conducted a repeated cross-sectional study combining 2010–19 U.S. National Survey of Drug Use and Health (NSDUH). Alcohol consumption was categorized as no use, low-risk use, and high-risk use. Outcomes include past-month tobacco and/or cannabis use, nicotine dependence, and/or frequent cannabis use. We employed linear time trends and multivariable logistic regressions.

Results
We included 395 256 participants aged ≥18 years. From 2010 to 2019, the prevalence of tobacco use and nicotine dependence decreased while that of any and frequent cannabis use increased (P &lt; .05). Tobacco use decreased faster in people with low−/high-risk alcohol use than no use (24% and 22% vs. 16%), whereas any cannabis use increased more rapidly in the no use group (155% vs. 77% in low- and 31% increase in high-risk groups). Among those with high-risk alcohol use, Hispanic individuals were less likely to use tobacco, cannabis, and both tobacco and cannabis, while non-Hispanic Black (NH Black) were more likely to use cannabis and both tobacco and cannabis than NH White counterparts (P &lt; .05).

Conclusion
Past-month tobacco use decreased, while cannabis use increased significantly across all alcohol consumption levels. Sociodemographic subgroups, such as NH Black individuals and those with psychiatric comorbidities, showed increased odds of polysubstance use, underscoring the need for targeted public health interventions.
Estimating the time-varying emission rate of peracetic acid
Authors: Hines Ryan , Chen Chun-Yu , Nicas Mark , Ramachandran Gurumurthy 
Published: January 2025

Abstract
The use of peracetic acid (PAA) as a general disinfectant has seen increasing usage in recent years, and although it is a strong irritant, exposure monitoring for PAA may often be difficult due to relatively high costs and the potential for interferences by other co-occurring chemicals such as hydrogen peroxide. These issues with exposure monitoring make modeling a potentially useful tool in exposure assessment of PAA if model parameters can be accurately determined. This study estimates the time-varying mass emission rate of PAA for use in exposure modeling by using the small spill model and examines the effect of various environmental conditions on the PAA evaporation rate, including surface roughness/substrate, general ventilation rate, and local wind speed. The relatively high evaporation rate constant (1.18 min−1) determined did not vary significantly with these parameters, suggesting it is applicable across a wide range of common environmental conditions. In addition, in a controlled chamber setting, the first-order decay rate constant for PAA in air was determined to be 0.5 h−1. The corresponding half-life of 83 min is approximately 4 times longer than previous estimates. This decay rate should be accounted for in future modeling and exposure assessments. To evaluate the estimated evaporation rate, trials were conducted in a highly controlled exposure chamber using conditions similar to those found in healthcare settings to compare predicted modeled concentrations to those made by a real-time detection instrument, SafeCide 2.0 (ChemDAQ, Inc.). The results of the trials indicate that the evaporation rate constant and well-mixed room model perform well in predicting the concentration of PAA over a range of conditions. Moreover, the modeling results and measured concentrations across all trials indicate a high potential for overexposure to PAA. Therefore, exposure controls must be adequate when considering the use of PAA as a general disinfectant.
Crypt4GH-JS: securely storing sensitive data online with client-side encryption
Authors: Thelen Fabienne , Hochmuth Jannis , Griep Sven , Schwab Benedikt , Goesmann Alexander , Förster Frank 
Published: January 2025

Abstract

Motivation and Results
Crypt4GH-JS is a browser-ready implementation of the Crypt4GH file encryption standard written in JavaScript. While having minimal to no impact on data upload and download throughput this library enables on-the-fly encryption of arbitrary data in web applications, regardless of whether on the client or server side. As development moves more and more toward cloud-native applications, this library represents a significant step forward for flexible data security in the context of opaque cloud storage systems.

Availability and implementation
Crypt4GH-JS can be installed via Node Package Manager (https://www.npmjs.com/package/crypt4gh_js) or through its public GitHub Repository (https://github.com/fathelen/crypt4ghJS), where the source code is available. Crypt4GH-JS can be tested in the browser using our demonstration website, which can be found at: https://fathelen.github.io/crypt4ghJS/.
Unveiling Schizophrenia: a study with generalized functional linear mixed model via the investigation of functional random effects
Authors: Rui Rongxiang , Xiong Wei , Pan Jianxin , Tian Maozai 
Published: January 2025

Summary
Previous studies have identified attenuated pre-speech activity and speech sound suppression in individuals with Schizophrenia, with similar patterns observed in basic tasks entailing button-pressing to perceive a tone. However, it remains unclear whether these patterns are uniform across individuals or vary from person to person. Motivated by electroencephalographic (EEG) data from a Schizophrenia study, we develop a generalized functional linear mixed model (GFLMM) for repeated measurements by incorporating subject-specific functional random effects associated with multiple functional predictors. To assess the significance of these functional effects, we employ two different multivariate functional principal component analysis methods, which transform the GFLMM into a conventional generalized linear mixed model, thereby facilitating its implementation with standard software. Furthermore, we introduce a cutting-edge testing approach utilizing working responses to detect both subject-specific and predictor-specific functional random effects. Monte Carlo simulation studies demonstrate the effectiveness of our proposed testing method. Application of the proposed methods to the Schizophrenia data reveals significant subject-specific effects of human brain activity in the frontal zone (Fz) and the central zone (Cz), providing valuable insights into the potential variations among individuals, from healthy controls to those diagnosed with Schizophrenia.
Contributions of connectional pathways to shaping Alzheimer’s disease pathologies
Authors: Bougacha Salma , Roquet Daniel , Landeau Brigitte , Saul Elise , Naveau Mikaël , Sherif Siya , Bejanin Alexandre , Dhenain Marc , Raj Ashish , Vivien Denis , Chetelat Gaël 
Published: January 2025

Abstract
Four important imaging biomarkers of Alzheimer’s disease, namely grey matter atrophy, glucose hypometabolism and amyloid-β and tau deposition, follow stereotypical spatial distributions shaped by the brain network of structural and functional connections. In this case-control study, we combined several predictors reflecting various possible mechanisms of spreading through structural and functional pathways to predict the topography of the four biomarkers in amyloid-positive patients while controlling for the effect of spatial distance along the cortex. For each biomarker, we quantified the relative contribution of each predictor to the variance explained by the model. We also compared the contribution between apolipoprotein E-ɛ4 carriers and non-carriers. We found that topological proximity to areas of maximal pathology through the functional connectome explained significant parts of variance for all biomarkers and that functional pathways totalized more than 30% of contributions for hypometabolism and amyloid load. By contrast, atrophy and tau load were mainly predicted by structural pathways, with major contributions from inter-regional diffusion. The ɛ4 allele modulated contributions to the four biomarkers in a way consistent with compromised brain connectomics in carriers. Our approach can be used to assess the contribution of concurrent mechanisms in other neurodegenerative diseases and the possible modifying impact of relevant factors on this contribution.
A multi-centre UK-based survey on angioedema secondary to acquired C1 inhibitor deficiency
Authors: Morsi Hadeil , Huissoon Aarnoud , Grammatikos Alexandros , Whyte Andrew , Manson Ania , Ekbote Anjali , Sivadasan Anju , Boulton Anne Pacita Rosillo , Herwadkar Archana , Anantharachagan Ariharan , Price Arthur , Steele Cathal , Stroud Catherine , Chopra Charu , Arnold Dilani , Eren Efrem , Cleave Elizabeth , Drewe Elizabeth , Moon Emily , Zinser Emily , Hayman Grant , Alachkar Hana , Ghanta Harichandana , Bourne Helen , Abdelhakam Intisar , Dempster John , Townsend Katie , Sooriyakumar Kavitha , Lorenzo Lorena , Dziadzio Magdalena , Ahuja Manisha , Prasinou Maria , Frleta-Gilchrist Marina , Zhang Michael , Thomas Moira , Vijayadurai Pavaladurai , Vaitla Prashantha Madhuri , Sargur Ravishankar , Herriot Richard , Yellon Robert L , Murng Sai Hurng Kham , Drinkwater Sara , Denness Sarah , Denman Sarah , Elkhalifa Shuayb , Savic Sinisa , Kiani-Alikhan Sorena , Coulter Tanya I , El-Shanawany Tariq , Rahman Tasneem , Garcez Tomaz , Yong Patrick F K , Jain Rashmi 
Published: January 2025

Abstract

Background
Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK is required to inform management.

Objectives
To describe the disease burden of AAE-C1-INH, long-term prophylaxis (LTP) and the clinical, immunochemical and treatment profiles of AAE-associated diseases in UK.

Method
Retrospective data on 117 AAE-C1-INH patients were collected using a national survey proforma across 25/34 Adult Clinical Immunology and Allergy centres in UK. Other European cohorts were compared.

Results
Median age at AAE-C1-INH diagnosis was 65 years with 3.4% of patients diagnosed below 40 years. The median delay in diagnosis was one year. Antifibrinolytics and attenuated androgens showed comparable efficacy as LTP 88.9% and 89.5%, respectively. A haematological disorder was identified in 83.8% AAE-C1-INH patients compared to 3.4% autoimmune diseases. The predominant haematological disorders were splenic marginal zone lymphoma (SZL) 34% followed by MGUS 16%. The severity of angioedema did not depend on the associated disease. Anti-C1INH-autoantibodies testing was limited at 23.1%. Rituximab monotherapy was effective in treating 9/9 SZL and 1/2 MGUS-associated AAE-C1-INH. Rituximab efficacy was independent of anti-C1INH-autoantibodies detection with response in 3/3 seronegative and 4/4 seropositive patients

Conclusion
The diagnosis of AAE-C1-INH should not be overlooked below the age of 40 years. The choice of oral LTP should be informed by propensity to side-effects. B-cell depletion could be considered in treating monoclonal B cell disorder-associated-AAE-C1-INH in the absence of haematological indications. Further studies are required to address the clinical utility of anti-C1INH-autoantibodies.
The changes in the ratio of Dicer1 transcripts can participate in the neuronal hypoxic response by regulating miR-29b
Authors: Liu Linan , Liu Yingxin , Sun Yongfeng , Lu Xian , Ji Yong , Zhao Xiujuan , Li Jun , Liu Chuncheng 
Published: January 2025

Abstract
The nervous system is highly dependent on the supply of oxygen and nutrients, so when demand for oxygen exceeds its supply, hypoxia is induced. The hippocampus is very important in the nervous system. It has the ability to control human behavior, memory, emotion, and so on. Therefore, when the hippocampus is damaged by hypoxia, it may cause nervous system diseases such as Alzheimer’s disease, Parkinson’s disease, and stroke. Alternative splicing plays an important regulatory role in the processes of growth and disease occurrence and development. However, the function of hypoxia-induced alternative splicing in neurological diseases needs to be further studied. Therefore, we performed hypoxia stress on mouse hippocampal neuron HT22 cells and then analyzed differentially expressed genes and differential alternative splicing events by next-generation sequencing. Through bioinformatics analysis and verification, it was found that hypoxia stress regulated the expression of Rbm15 and the ratio of Dicer1 transcripts in HT22 cells. The change in the ratio of Dicer1 transcripts may be related to the upregulation of miR-29b under hypoxia stress. This study can provide multiple time point sequencing results and a theoretical basis for the study of hypoxia-related gene alternative splicing.
The hemispheric differences in prefrontal function of Internet game disorder and non-Internet game disorder: an activation likelihood estimation meta-analysis
Authors: Xue Rui , Li Jiaqi , Yang Haibo 
Published: January 2025

Abstract
This study explored the differences in brain activation between individuals with and without Internet gaming disorder (IGD) through activation likelihood estimation analysis. In total, 39 studies were included based on the inclusion and exclusion criteria by searching the literature in the PubMed and Web of Science databases, as well as reading other reviews. The analysis revealed that the activated brain regions in IGD were the right inferior frontal gyrus, left cingulate gyrus, and left lentiform nucleus. In comparison, the activated brain regions in non-IGD were the left middle frontal, left inferior frontal, left anterior cingulate, left precentral, and right precentral gyri. The results of the present study on differences in activation further confirm existing theoretical hypotheses. Future studies should explore hemispheric differences in prefrontal brain function between IGD and non-IGD.
Reactivating and reorganizing activity-silent working memory: two distinct mechanisms underlying pinging the brain
Authors: Yang Can , He Xianhui , Cai Ying 
Published: January 2025

Abstract
Recent studies have proposed that visual information in working memory (WM) can be maintained in an activity-silent state and reactivated by task-irrelevant high-contrast visual impulses (“ping”). Although pinging the brain has become a popular tool for exploring activity-silent WM, its underlying mechanisms remain unclear. In the current study, we directly compared the neural reactivation effects and behavioral consequences of spatial-nonmatching and spatial-matching pings to distinguish the noise-reduction and target-interaction hypotheses of pinging the brain. Initially, in an electroencephalogram study, our neural decoding results showed that spatial-nonmatching pings reactivated activity-silent WM transiently without changing the original WM representations or recall performance. Conversely, spatial-matching pings reactivated activity-silent WM more durably and further reorganized WM information by decreasing neural representations’ dynamics. Notably, only the reactivation strength of spatial-matching pings correlated with recall performance and was modulated by the location of memorized items, with neural reactivation occurring only when both items and pings were presented horizontally. Consistently, in a follow-up behavioral study, we found that only spatial-matching, horizontal pings impaired recall performance compared to no ping. Together, our results demonstrated two distinct mechanisms underlying pinging the brain, highlighting the critical role of the ping’s context (i.e. spatial information) in reactivating and reorganizing activity-silent WM.
Neural correlates of reciprocity bias: social debts modulate unfairness perception of violation during third-party observation
Authors: Zhang Yinling , Chen Rongrong , Liu Siqi , Chen Peiqi , Mai Xiaoqin 
Published: January 2025

Abstract
The phenomenon of beneficiaries ignoring benefactors’ violations, ranging from everyday favors to bribes, is widespread yet lacks targeted theoretical and empirical attention. We propose a conceptual framework that includes “social debt” and “reciprocity bias,” where “social debt” is defined as information about benefits bestowed by benefactors and “reciprocity bias” as the influence of social debt on beneficiaries’ perceptions and decisions in situations involving the benefactor. To investigate this bias in moral perception and its cognitive–neural mechanisms, we manipulated three levels of social debt (none, less, more) by varying the amount of unasked benefits that benefactors bestowed upon participants. Participants then observed the distributor’s fair or unfair allocation of resources to another person, while their electroencephalography (EEG) was recorded. Results indicate that more (vs. none/less) social debt reduces perceptions of unfairness toward benefactors’ violations and enhances fairness perceptions of their norm adherence. This was, accompanied by the diminished fairness effect on fronto-centered P2 and a reversal fairness effect on the power of theta oscillations (4 to 7 Hz). These findings support a multilevel reciprocity bias in fairness perception, suggesting that strong social debt may heighten concern for benefactor’s interests and increase the adaptive value of their violations at the cognitive–neural level.
Characterization of LTBP2 mutation causing mitral valve prolapse
Authors: Shpitzen Shoshi , Rosen Haim , Ben-Zvi Ayal , Meir Karen , Levin Galina , Gudgold Amichay , Ben Dor Shifra , Haffner Rebecca , Zwas Donna R , Leibowitz David , Slaugenhaupt Susan A , Banin Eyal , Mizrachi Rotem , Obolensky Alexey , Levine Robert A , Gilon Dan , Leitersdorf Eran , Tessler Idit , Reshef Noga , Durst Ronen 
Published: January 2025

Abstract

Aims
Mitral valve prolapse (MVP) is a common valvular disorder associated with significant morbidity and mortality, with a strong genetic basis. This study aimed to identify a mutation in a family with MVP and to characterize the valve phenotype in LTBP2 knockout (KO) mice.

Methods and results
Exome sequencing and segregation analysis were performed on a large family with MVP. Two mouse strains were generated: a complete KO of the LTBP2 gene and a knockin (KI) of the human mutation. At 6 months, phenotyping was conducted using echocardiography, histology, eye optical coherence tomography, and quantitative polymerase chain reaction analysis for TGF-β signalling targets (periostin/POSTN, RUNX2, and CTGF) in valve tissues. LTBP2 rs117800773 V1506M mutation exhibited segregation with MVP. LTBP2 KO mice had a higher incidence of myxomatous changes by histology (7 of 9 of KO vs. 0 of 7 control animals, P = 0.00186) and echocardiography (7 of 9 vs. 0 of 8, P = 0.0011). LTBP2 KI mice for the human mutation showed a significantly elevated myxomatous histological phenotype (8 of 8 vs. 0 of 9, P = 0.00004) as well as by echocardiography (6 of 8 vs. 0 of 9, P = 0.00123). Knockout mice demonstrated an increase in the depth of the anterior chamber as well as reduced visual acuity. LTBP2 KO mice demonstrated overexpression of both TGF-β signalling targets RUNX2 and periostin (P = 0.0144 and P = 0.001826, respectively).

Conclusion
We report a KO mouse strain with an LTBP2 mutation, demonstrating a valve phenotype, alongside a family with a novel mutation linked to MVP.
Bumblebees prefer sulfoxaflor-contaminated food and show caste-specific differences in sulfoxaflor sensitivity
Authors: Orr Sarah E , Xu Jixiang , Juneau Wanvimol C , Goodisman Michael A D 
Published: January 2025

Abstract
More than 30% of human food crop yield requires animal pollination. In addition, successful crop production depends on agrochemicals to control pests. However, agrochemicals can have negative consequences on beneficial insect pollinators, such as bees. We investigated the effects of an emerging class of pesticides, sulfoximines, on the common eastern bumblebee, Bombus impatiens. We performed a series of 96-hour toxicity tests on microcolonies of laboratory-reared B. impatiens. Our data showed that sulfoxaflor (SFX) is significantly less toxic to B. impatiens than historically used neonicotinoid pesticides, such as thiamethoxam. Further, for the first time, we found significant differences among castes in sensitivity to SFX; workers and drones were more sensitive than queens. These findings are notable because they reveal both caste and sex-specific differences in bumblebee sensitivity to pesticides. Interestingly, we found no evidence that bumblebees avoid SFX-contaminated sugar syrup. To the contrary, B. impatiens workers had an apparent preference for SFX-contaminated sugar syrup over sugar syrup alone. Overall, our investigation provides novel information on an important pesticide and may help inform regulatory decisions regarding pesticide use.