bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pragmatic Randomized Control Trial of a Coordinated Community Response: Increasing Access to Services for At-Risk Older Adults
Authors: Maxwell Christopher D. , Rodgers Kourtnie , Pickering Carolyn E. Z. 
Published: January 2022

ABSTRACT

Background
Elder abuse, neglect, and financial exploitation (EANF) impacts over five million community-dwelling older adults. Yet, no evidence-based intervention models exist that prevent EANF.

Objectives
In this article, we describe the assessment of process outcomes for a Community Complex Care Response Team (C3RT) model developed, via a practitioner–researcher partnership, to reduce instances of EANF victimization among higher risk community-dwelling older adults by identifying and coordinating their service needs. Specifically, we evaluated whether this C3RT approach produced more service coordination among providers (measured as documented interagency communications), more referrals for services, and more enrollment in services.

Methods
A pragmatic randomized control trial using a 1:1 randomization scheme allocated participants to either the C3RT intervention (N = 74) or standard practice (N = 72) group offered by a local Area Agency on Aging. Outcome data were extracted from the participants' administrative service records.

Results
The participants assigned to C3RT had significantly more interagency communications and services provided (p < 0.05) than those in standard practice.

Conclusions
Communications and services increased across a broad range of multidisciplinary services, which attend to the social determinants of health. This study is the first to use objective outcome measures to evaluate the processes of a coordinated community response approach systematically.
A Model for Early Endoscopic Detection of High‐Risk Gastroesophageal Varices in Children With Biliary Atresia
Authors: Ackermann Oanez , de Boissieu Paul , Bernard Olivier , Gonzales Emmanuel , Jacquemin Emmanuel , Duché Mathieu 
Published: January 2022

ABSTRACTObjective:In children with biliary atresia and portal hypertension, progression to gastroesophageal varices carrying a risk of bleeding depends on age, total serum bilirubin concentration and initial endoscopic features. We report an attempt to use these factors for early detection of high‐risk varices (HRVs).Methods:Based on different combinations of these factors, a model was set to estimate the probabilities of emergence of HRVs at various time intervals. A 10% probability was chosen to set the date of the next endoscopy in children who did not display HRVs initially. A total of 113 children without HRVs who underwent their first endoscopy before age 8 in 2013–2020 were included. A comparison was made with children seen during the period 1990–2012 when this model was not used.Results:In all, 65 of the 113 children underwent one to five additional endoscopies at dates set according to the model. The emergence of HRVs was recorded in 22 children after a mean interval of 14 months and was managed by endoscopic primary prophylaxis in all but one who underwent liver transplantation. Three other children bled before the next planned endoscopy. Compared with 175 children of the same age ranges without HRVs in the period 1990–2012, the use of the model was associated with a faster detection of HRVs with a lower number of endoscopic procedures (P = 0.0022 and P = 0.023, respectively).Conclusion:The results suggest that the model reported may be a useful tool for the early detection of HRVs to allow primary prophylaxis of bleeding.
Does Immunohistochemistry Add to Morphology in Differentiating Trichoepithelioma, Desmoplastic Trichoepithelioma, Morpheaform Basal Cell Carcinoma, and Microcystic Adnexal Carcinoma?
Authors: Mohanty Sambit K. , Sardana Ruhani , McFall Michael , Pradhan Dinesh , Usmani Amena , Jha Shilpy , Mishra Sourav K. , Sampat Nakul Y. , Lobo Anandi , Wu Julie M. , Balzer Bonnie L. , Frishberg David P. 
Published: January 2022

Background:
The distinction among cutaneous basaloid neoplasms such as trichoepithelioma (TE), desmoplastic trichoepithelioma (DTE), morpheaform basal cell carcinoma (MBCC), and microcystic adnexal carcinoma (MAC) can be difficult, especially in superficial biopsies. As the treatment plan of each entity is different, accurate characterization is important for appropriate management. While TE and DTE are benign neoplasms with indolent behavior, MBCC and MAC are typically locally aggressive. The expression of several recently described immunohistochemical (IHC) markers, including p40, IMP3, and ProEx C, has not been adequately established in cutaneous neoplasms. We explored the potential utility of a broad IHC panel, including previously reported and novel markers to differentiate TE, DTE, MBCC, and MAC.

Design:
A total of 35 archival cases [TE (n=14), DTE (n=9), MBCC (n=6), and MAC (n=6)] were stained with 9 IHC markers: p40, IMP3, ProEx C, p16, CK20, Ki-67, androgen receptor, D2-40, and beta-catenin. Tumors with >5% immunoreactivity were scored as positive. The intensity was scored on a scale from 1+ to 3+. The pattern of positivity- nuclear, cytoplasmic, membranous, or in combination; peripheral or central distribution with lesion was also recorded.

Results:
CK20 (in contrast to prior studies) and IMP3 were negative in all cases. Likewise, with the exception of one case of TE, androgen receptor showed no immunoreactivity in all categories. No significant difference was observed in the expression of beta-catenin, p16, ProEx C, and p40 among the four groups of cutaneous neoplasms. The mean Ki-67 labeling index for MBCC (8%) was slightly higher than DTE (3%). Interestingly, the proliferation index for TE (15%) was significantly higher than that of MBCC. All six cases of MAC and 36% of TEs expressed D2-40; neither the MBCC nor DE cases showed D2-40immunoreactivity. Also, we confirmed the previously published observation of scattered CK20 positive Merkel cells in the epidermis of all cases of DTE; whereas, no Merkel cells were identified in MBCC and MAC cases.

Conclusions:
Except Ki-67, our IHC panel showed no significant added diagnostic utility of IHC in discriminating among TE, DTE, MBCC, and MAC. Among the four cutaneous neoplasms, DTE and MBCC show a small but discernible difference in Ki-67.
Release of Matrix Metalloproteinases by Macrophages in Radicular Cysts and Residual Radicular Cysts
Authors: França Glória M. , Medeiros Cristianne K.S. , Almeida Dennys R.M.F. , Pinheiro Juliana C. , de Andrade Ana L.D.L. , Santos Pedro P.A. , Galvão Hébel C. 
Published: January 2022

Introduction:
Radicular cysts (RCs) and residual radicular cysts (RRCs) are the sequelae of dental caries and that leads to proliferation of epithelial rests of Malassez in periapical tissues.

Objectives:
The aim was to evaluate the relationship between Langerhans cells, macrophages, matrix metalloproteinases (MMP-9, MMP-13), and tumor necrosis factor-alpha (TNF-α) in the capsule and lining epithelium of cystic lesions.

Materials and Methods:
Twenty RCs and 20 RRCs were submitted to immunohistochemical analysis with anti-CD68, anti-CD1a, anti-MMP-9, anti-MMP-13, and anti-TNF-α antibodies. The Mann-Whitney test and the Spearman correlation test were used for analysis of the data (P<0.05).

Results:
The immunoexpression of MMP-13 and CD68 was significantly higher in RCs when compared with RRCs (P=0.011 and 0.012, respectively). The presence of an intense inflammatory infiltrate was significantly correlated with the immunoexpression of CD68 in RCs (P=0.025). Expression of CD68 showed a significant positive correlation with MMP-13 (P=0.015). A moderate correlation was observed between MMP-9 and MMP-13 (P=0.010). TNF-α expression was more common in RCs (P=0.001). CD1a was more frequently expressed in atrophic epithelium (P=0.041) and was significantly correlated with TNF-α (P=0.014).

Conclusion:
Langerhans cells induce a greater release of TNF-α which, in turn, is responsible for the stimulation of M1 macrophages. Higher immunoexpression of MMP-13 and MMP-9 is observed in the early stages of RCs compared with RRCs. Therefore, the toxins of microorganisms present in highly inflamed RCs are the main factors triggering a proinflammatory immune response and greater cystic expansion in the early stages of these lesions.
Isolation and Identification of taxonomically diverse bacterial endophytes from citrus in Punjab Pakistan
Authors: Mushtaq Sehrish , Shafiq Muhammad , Ashraf Tehseen , Qureshi Fahim , Haider Muhammad Saleem , Atta Sagheer 
Published: January 2022

AbstractCitrus is an economically important fruit crop grown in all provinces of Pakistan, while Punjab accounting for 95 percent of total production due to its favorable climate for citrus production. Commercially grown varieties in Pakistan include sweet oranges, grapefruits, Mandarine, Lime, and lemon. The goal of this research was to see how diverse the cultivable bacterial populations are found in citrus cultivars. Out of 90 isolated cultures, 37 endophytic bacterial species and 15 different genera of bacteria were characterized based on morphological, biochemical, and molecular methods from citrus leaves. All the isolated bacteria were subjected to PCR amplification through 16S rDNA followed by sequencing. RDP base classification revealed that class Bacilli has the largest percentage of isolates, whereas class Alpha, Beta, and Gamma Proteobacteria have the lowest percentage among all genotypes used. According to the findings, the phylum Firmicutes contains a common genus (Brevibacterium, 1%; Enterococcus, 6%; Staphylococcus, 7% and Bacillus, 60%). Alpha (Rhizobium) beta (Burkholderia cepacia; Comamonas terigena) gamma Proteobacteria (Enterobacter hermachei (1%), Klebsiella pneumoniae (1%), Proteus mirabilis (8%), Pseudomonas aeruginosa (5%), Psychrobacter pulmonis and Yersinia molalretti (1%) respectively. These results revealed that cultivars of the plants might contribute to the structure and endophytic bacterial communities associated with citrus. Endophytes extracted from leaf samples of different citrus cultivars in Pakistan are reported for the first time. The idea of employing endophytes bacteria to produce enzymes stimulate plant growth, and its purpose as a biological control agent will be investigated in the future.
Wnt5A supports antigen cross-presentation and CD8 T cell activation
Authors: Sarraf Tresa Rani , Sen Malini 
Published: January 2022

AbstractAntigen processing, cross-presentation, and antigen-specific CD8 T cell response form part and parcel of T cell-mediated immunity. Yet, lacunae remain in our understanding of antigen processing/presentation and CD8 T cell response. Given the association of Wnt5A signaling with immune homeostasis, we evaluated the utility of Wnt5A in antigen processing, cross-presentation, and CD8 T cell activation. Using mouse bone marrow-derived dendritic cells as antigen-presenting cells and ovalbumin as a model antigen we found that Wnt5A mediated regulation of actin and proteasome dynamics is inherently associated with antigen processing. A Wnt5A-Actin-Protasome axis also contributes to antigen cross-presentation and antigen responsive CD8 T cell expansion. In concurrence with these observations, we demonstrated impaired activation of ovalbumin-specific CD8 T cells in ovalbumin immunized Wnt5A heterozygous mice as illustrated by their poor CD8 T cell recall response to ovalbumin when compared to similarly immunized wild type cohorts. Our results suggest that Wnt5A signaling-directed antigen processing/presentation could be vital for generating CD8 T cell recall response to antigen, thus shedding light on a critical parameter of immunity.
Identification of bacteria strains using the Recombinase Polymerase Amplification assay on a miniaturized solid-state pH sensor
Authors: Nguyen Anh H. , Malhotra Samir , Lau Michael P.H. , Cao Hung 
Published: January 2022

AbstractRapid identification of bacteria based on nucleic acid amplification allows dealing with the detection of pathogens in clinical, food, and environmental samples. Amplification product must be detected and analyzed by external devices or integrated complicated optical systems. Here, we developed a solid-state pH electrode based on iridium oxide (IrO2) films to measure released hydrogen ions (H+) from isothermal nucleic acid (NA) amplification of bacterial samples. By recombinase polymerase amplification (RPA), we achieved rapid (< 15 min) and sensitive (<30 copies) detection with an accuracy of about 0.03 pH. The RPA-based hydrogen ion sensing assay shows higher specificity, sensitivity, and efficiency as the same polymerase chain reaction (PCR) methods. We initially used the RPA-based sensor to detect E. coli species in laboratory samples. Among, 27 random laboratory samples of E. coli samples, 6 were found to be DH5alpha, 9 BL21, 3 HB101, 6 TOP10, and 3 JM109. The electrical detection of amplification provides generally applicable techniques for the detection of nucleic acid amplification, enabling molecular diagnostic tests in the field and integrating data transmission to the mobile device. These results can be future developed into an efficient tool for rapid on-site detection of bacterial pathogens in clinical samples.
Italian wine sustainability: new trends in consumer behaviors for the millennial generation
Authors: Gazzola Patrizia , Grechi Daniele , Pavione Enrica , Gilardoni Gloria 
Published: January 2022

PurposeThe role of sustainability is predominant in many aspects of consumer purchasing decisions. Millennials and young people are, in this field, potential players who buy and consume wine with ecosustainable decisions but, in the literature, these aspects are analyzed with nonuniform findings. This paper aims to investigate the wine consumption among young people belonging to the millennial generation, Y generation and Z generation considering also the gender.Design/methodology/approachThis study uses a questionnaire with 2000 respondents. The data are analyzed to understand consumption decisions in the wine sector. This information is analyzed through descriptive and inferential statistics (hypothesis test and multiple regression).FindingsThe results of the paper show a clear propensity to be sustainable of the young generation compared with the elderly, highlighting the role of Millennials. Moreover, considering gender, there is a greater sustainable wine tendency (considering both the environmental and the economic/decisional component) in female compared with male.Research limitations/implicationsThis work reflects the Italian reality of the pre-COVID-19 period. Obviously, the pandemic situation and the geographic scenario analyzed could change the results of a second wave of the survey.Social implicationsThis study contributes to improve the knowledge concerning the wine consumption habits of Italian young generations.Originality/valueThe paper manages to underline the different aspects of sustainability in the wine purchasing decisions by young consumers by focusing on the considered generations.
Drought assessment in paddy rice fields using remote sensing technology towards achieving food security and SDG2
Authors: Shams Esfandabadi Hadi , Ghamary Asl Mohsen , Shams Esfandabadi Zahra , Gautam Sneha , Ranjbari Meisam 
Published: January 2022

PurposeThis research aims to monitor vegetation indices to assess drought in paddy rice fields in Mazandaran, Iran, and propose the best index to predict rice yield.Design/methodology/approachA three-step methodology is applied. First, the paddy rice fields are mapped by using three satellite-based datasets, namely SRTM DEM, Landsat8 TOA and MYD11A2. Second, the maps of indices are extracted using MODIS. And finally, the trend of indices over rice-growing seasons is extracted and compared with the rice yield data.FindingsRice paddies maps and vegetation indices maps are provided. Vegetation Health Index (VHI) combining average Temperature Condition Index (TCI) and minimum Vegetation Condition Index (VCI), and also VHI combining TCImin and VCImin are found to be the most proper indices to predict rice yield.Practical implicationsThe results serve as a guideline for policy-makers and practitioners in the agro-food industry to (1) support sustainable agriculture and food safety in terms of rice production; (2) help balance the supply and demand sides of the rice market and move towards SDG2; (3) use yield prediction in the rice supply chain management, pricing and trade flows management; and (4) assess drought risk in index-based insurances.Originality/valueThis study, as one of the first research assessing and mapping vegetation indices for rice paddies in northern Iran, particularly contributes to (1) extracting the map of paddy rice fields in Mazandaran Province by using satellite-based data on cloud-computing technology in the Google Earth Engine platform; (2) providing the map of VCI and TCI for the period 2010–2019 based on MODIS data and (3) specifying the best index to describe rice yield through proposing different calculation methods for VHI.
A novel adaptive discrete grey prediction model for forecasting development in energy consumption structure—from the perspective of compositional data
Authors: Qian Wuyong , Zhang Hao , Sui Aodi , Wang Yuhong 
Published: January 2022

PurposeThe purpose of this study is to make a prediction of China's energy consumption structure from the perspective of compositional data and construct a novel grey model for forecasting compositional data.Design/methodology/approachDue to the existing grey prediction model based on compositional data cannot effectively excavate the evolution law of correlation dimension sequence of compositional data. Thus, the adaptive discrete grey prediction model with innovation term based on compositional data is proposed to forecast the integral structure of China's energy consumption. The prediction results from the new model are then compared with three existing approaches and the comparison results indicate that the proposed model generally outperforms existing methods. A further prediction of China's energy consumption structure is conducted into a future horizon from 2021 to 2035 by using the model.FindingsChina's energy structure will change significantly in the medium and long term and China's energy consumption structure can reach the long-term goal. Besides, the proposed model can better mine and predict the development trend of single time series after the transformation of compositional data.Originality/valueThe paper considers the dynamic change of grey action quantity, the characteristics of compositional data and the impact of new information about the system itself on the current system development trend and proposes a novel adaptive discrete grey prediction model with innovation term based on compositional data, which fills the gap in previous studies.
Higher education teachers' perception and use of Content Representations in lesson study
Authors: Hervas Gabriel , Medina José Luis 
Published: January 2022

Purpose“Content Representations” (CoRes) is an instrument that links content with aspects about its teaching and is recognized for its utility designing lessons and elucidating teachers' knowledge. Lesson study (LS) is a practice through which teachers collaborate to plan, teach and reflect on a lesson. Both have been acknowledged separately as being valuable for teachers' training; however, there is little research addressing the consequences of combining them. This study filled in that gap by examining how higher education (HE) teachers used the CoRes and perceived its integration within LS.Design/methodology/approachThe authors performed a multiple case study with features of ethnomethodology and conducted an inductive content analysis of the data gathered through document analysis, in-depth semi-structured interviews and participant observation. The research was approved by the ethics committee of the host university, and participants were faculty members from different health sciences disciplines.FindingsThe authors found that participants considered that the use of the CoRes during LS allowed them to organize their ideas, consider more details for lesson design, address new topics and engage in greater reflection. However, participants (specially senior faculty) showed a superficial dedication to filling in the CoRes and considered the instrument bothersome, urging caution when engaging in the combined practice of CoRes and LS.Originality/valueThis is the first research in the international literature approaching the integration of the CoRes and LS with HE teachers. Its results fill a research gap and can help LS practitioners make an informed decision about whether to incorporate CoRes into it.
Reliability analysis and hypothesis testing of critical success factors of total productive maintenance
Authors: Kalpande Shyamkumar D. , Toke Lalit K. 
Published: January 2022

PurposeThis paper deals with concept of total productive maintenance (TPM) and its implementation approach. It also presents the identification of critical factors for effective implementation of TPM. The reliability analysis identified potential areas where more concentration is required. The application of hypothesis testing in productivity maintenance should be promoted by parametric test and significantly instrumental in explanation of phenomena. It is also indispensable to better understand quality data and provide guidance to production control.Design/methodology/approachThe various critical success factors of TPM implementation has organised into set of eight performance measure and thirty three sub-factors for getting the in-depth details of each indicator. The paper identifies the reliability of these factors and understands the problem with greater clarity and its ramification. Researcher collected responses from forty one manufacturing organisations through structured designed questionnaire. The reliability analysis was carriedout by calculating the value of Cronbach's alpha method. To draw the meaningful conclusions supported by relevant empirical data, provisional formulation is required, and it was carried by hypothesis testing. In this test, samples are taken from a population with known distribution (normal distribution), and a test of population parameters is executed. It determines the relevancy of facts directs the researcher's efforts into productive channels. The statements were hypothetically tested by calculating the arithmetic value of Chi-Square (χ2) and MINITAB-19 software was used for identification of p-value.FindingsThis study identified that main factors and sub-factors of TPM which are critical for implementation of TPM. The study also avoids the complexities involved in implementing TPM by reliability analysis. It is found that all identified CSFs are reliable as Cronbach's alpha is above 0.6. The hypothesis testing shows that all alternative hypothesis statements are acceptable as Chi-Square (χ2) value has satisfied the conditions and null hypothesis are true as calculated p-value is less than the 0.05 for eight identified TPM critical factor.Originality/valueIn this paper researcher provides a comprehensive typology of TPM-CSFs, and its ranking and importance in manufacturing sector. The preparedness of such study related to TPM implementation is becoming a major sourcing base for the world and there is a paucity of such studies. Such studies are equally important in a global context.