bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dreiphasiger Netzsimulator mit virtueller Ausgangsimpedanz
Authors: Jonke Peter , Makoschitz Markus , Ertl Hans 
Published: December 2022

ZusammenfassungFür das Testen, Prüfen und Validieren von netzgekoppelten Komponenten wie z. B. PV-Wechselrichtern oder Batteriespeichersystemen kommen in der Regel Netzsimulatoren/AC-Simulatoren zum Einsatz, um deren Verhalten bei unterschiedlichen Spannungs- oder Frequenzprofilen zu untersuchen. Bei derartigen Versuchsaufbauten ist auch eine definierte Netzimpedanz vorgeschrieben, welche üblicherweise durch passive ohmsch-induktive RL-Impedanznetzwerke emuliert nachgebildet wird. Als Alternative dazu wird im Rahmen dieser Publikation ein auf virtueller Netzimpedanzemulation basierendes Netzsimulationssystem präsentiert, wodurch auf die genannten Leistungs-Impedanznetzwerke verzichtet werden kann und ein flexiblerer, programmierbarer Testbetrieb möglich ist.
Suitability of electroencephalography in brain death determination: a monocentric, 10-year retrospective, observational investigation of 428 cases
Authors: Rossi Simone , Mazza Gionathan , Del Testa Massimiliano , Giannotta Alessandro , Bartalini Sabina , Testani Elisa , Savelli Laura , Gabbrielli Mario , Vatti Giampaolo , Scolletta Sabino 
Published: December 2022

Abstract

Background
We aimed to verify the usefulness of electroencephalographic (EEG) activity recording (that is mandatory according to the Italian law), in addition to two clinical evaluations spaced 6 h, among the procedures of brain death determination (BDD) in adult individuals.

Methods
The study is a monocentric, retrospective analysis of all BDDs performed in the last 10 years at Policlinico Le Scotte in Siena (Italy).

Results
Of the 428 cases revised (mean age 67.6 ± 15.03 years; range 24–92 years), 225 were males and 203 females. In total, 212 out of 428 patients (49.5%) were donors. None of the BDD procedures were interrupted due to the reappearance of EEG activity (neither for clinical reasons) at any sampling time, with the exception of one case that was considered a false negative at critical reinspection of the EEG. In 6/428 cases (1.4%), a cardiac arrest occurred during the 6 h between the first and second evaluation, thus missing the opportunity to take organs from these patients because the BDD procedure was not completed.

Conclusions
Once the initial clinical examination before convening the BDD Commission has ascertained the absence of brainstem reflexes and of spontaneous breathing, and these clinical findings are supported by a flat EEG recording, the repetition of a 30-min EEG twice over a 6 h period seems not to add additional useful information to clinical findings. Current data, if confirmed in other centers and possibly in prospective studies, may help to promote a scientific and bioethical debate in Italy, as well as in other countries where the EEG is still mandatory, for eventually updating the procedures of BDD.
Can the cropping systems of the Nile basin be adapted to climate change?
Authors: Nkwasa Albert , Waha Katharina , Griensven Ann van 
Published: December 2022

AbstractClimate change poses a fundamental threat to agriculture within the Nile basin due to the magnitude of projected impacts and low adaptive capacity. So far, climate change impacts on agriculture for the basin have mostly been assessed for single-cropping systems, which may bias the results considering that the basin is dominated by different cropping systems, with about one-third of the crop area under double cropping. In this study, we simulate single- and double-cropping systems in the Nile basin and assess the climate change impacts on different cropping systems under two scenarios, i.e. “no adaptation” and “adaptation to a late-maturing cultivar”. We find that the mean crop yields of maize, soybean and wheat decrease with future warming without cultivar adaptation. We attribute this to the shortening of the growing season due to increased temperature. The decrease is stronger in all single-cropping systems (12.6–45.5%) than in double-cropping systems (5.9–26.6%). The relative magnitude of yield reduction varies spatially with the greatest reduction in the northern part of the basin experiencing the strongest warming. In a scenario with cultivar adaptation, mean crop yields show a stronger increase in double-cropping systems (14.4–35.2%) than single-cropping systems (8.3–13.7%). In this scenario, farmers could possibly benefit from increasing cropping intensities while adapting to late-maturing cultivars. This study underscores the importance of accounting for multiple-cropping systems in agricultural assessments under climate change within the Nile basin.
Evaluating the efficiency and determinants of mass tourism in Spain: a tourist area perspective
Authors: Sánchez-Sánchez Francisca J. , Sánchez-Sánchez Ana M. 
Published: December 2022

AbstractTourism is one of the fastest-growing economic sectors. This has piqued increasing interest in the evaluation of the performance of the sector. This paper joins this line of research by providing a potential framework for measuring efficiency in the context of a country such as Spain, where sun-and-sand tourism, usually associated with mass tourism, predominates. Tourist areas located on the coast provide the units of reference. Data Envelopment Analysis (DEA) is applied to determine the efficiency score and a Tobit-type model is employed to analyse the factors that determine efficiency. The results show that the impact of mass tourism on labour efficiency is geographically unequal, with the most efficient of the tourist areas located on the peninsular archipelagos. The analysis of the contribution of each input to the efficiency score reveals the pre-eminent role of tourism infrastructure as a lure for sun-and-sand tourism.
Formal verification confirms the role of p53 protein in cell fate decision mechanism
Authors: Mahmoud Eman Abdelaziz , Herajy Mostafa , Ziedan Ibrahim E. , Shehata Hazem I. 
Published: December 2022

AbstractThe bio-cell cycle is controlled by a complex biochemical network of signaling pathways. Modeling such challenging networks accurately is imperative for the understanding of their detailed dynamical behavior. In this paper, we construct, analyze, and verify a hybrid Petri net (HPN) model of a complex biochemical network that captures the role of an important protein (namely p53) in deciding the fate of the cell. We model the behavior of the cell nucleus and cytoplasm as two stochastic and continuous Petri nets, respectively, combined together into a single HPN. We use simulative model checking to verify three different properties that capture the dynamical behavior of p53 protein with respect to the intensity of the ionizing radiation (IR) to which the cell is exposed. For each IR dose, 1000 simulation runs are carried out to verify each property. Our verification results showed that the fluctuations in p53, which relies on IR intensity, are compatible with the findings of the preceding simulation studies that have previously examined the role of p53 in cell fate decision.
Characterization of cyanobacterial isolates from freshwater and saline subtropical desert lakes
Authors: Shawer Ehab , Elsaied Hosam , El-Gamal Ahmed , Sabae Shawky 
Published: December 2022

AbstractCharacterization of Cyanobacteria in lakes with different physicochemical properties provides insights into the diversity of this phylum and knowledge of their features that are relevant to biotechnology applications. Six Cyanobacterial isolates were recovered from freshwater Lake Nasser and saline Lake Qarun, Egypt. The isolates were identified based on both morphology and molecular markers, 16S rRNA, and RuBisCO cbbL genes. The isolates SN1, SN2, SN3, SN4, Q1, and Q2 showed homologies with Merismopedia, Oscillatoria, Limnothrix, Persinema, and Jacksonvillea, respectively. The cbbL sequences for isolates SN1, Q1, and Q2 represented the first records for candidates relating to the genera Merismopedia and Persinema, and Jacksonvillea, respectively. Biochemical contents, carbohydrates, proteins, lipids, pigments, and ash-free dry weight were measured for each isolate. Isolate SN2 had the highest content of allophycocyanin, 71 ± 4.8 mg/g DW, and phycoerythrin, 98 ± 6.7 mg/g DW, while the isolate SN4 had the highest composition of total protein, lipid, carotenoid, and chlorophyll a, recording 364.7 ± 6.4 mg/g DW, 67.6 ± 0.2 mg/g DW, 0.261 ± 0.01 mg/g DW, and 10 ± 0.6 mg/g DW, respectively. Isolate Q1 recorded the maximum amount of phycocyanin, 114 ± 20.7 mg/g DW among isolates. The isolate Q2 was observed to have the highest carbohydrate content, 274 ± 14.5 (mg/g DW), and ash-free dry weight, 891.8 ± 2.8 mg/g DW. Thus, the study indicated that the current isolates may represent promising resources for biotechnological applications.
Handheld echocardiography in patients with cardiovascular disease: to use or not to use, that is the question
Authors: Wierda Eric , Bouma Berto J. , van den Brink Renee B. A. 
Published: December 2022

AbstractThe physical examination is one of the most important diagnostic tools for physicians. Traditionally, a physical examination consists of inspection (looking), palpation (feeling), percussion (reflection of sound) and auscultation (listening). Handheld echography devices could become the new fifth element of a physical examination. The use of handheld echocardiography has recently increased because the devices have become smaller, easier to handle and more affordable. Handheld echocardiography is used by many specialists involved in acute cardiovascular care. In this narrative review we give a summary of the diagnostic accuracy and limitations of cardiovascular physical examination combined with handheld echocardiography. In patients with cardiovascular disease, adding handheld echocardiography to physical examination increases the sensitivity for detecting valvular heart disease (71% vs 46%) and left ventricular dysfunction with an ejection fraction < 50% (84% vs 43%). Handheld echocardiography might be better for ruling out diseases with a low pre-test probability than in confirming diseases with a high pre-test probability.
Access to urban green spaces in Hannover: An exploration considering age groups, recreational nature qualities and potential demand
Authors: Weber Raphael , Haase Annegret , Albert Christian 
Published: December 2022

AbstractCity dwellers' accessibility of urban green spaces (UGS) has recently gained immense interest in research and policy. Related scientific studies thus far have focused primarily on spatial distances, largely missing considerations of UGS qualities. We analysed the entire UGS setting of Hannover considering the recreational nature quality and potential demands to identify age-appropriate green spaces by applying a geographic information system analysis of several data sets. Additionally, we assessed the accessibility of UGS for different age groups, varying recreational nature qualities, and potential demands. Results indicate that children and elderly people have poor access to UGS that offers age-related requirements to enable unrestricted nature-based recreation. Nature quality and age-related requirements play a significant role in the assessment of UGS for recreation and accessibility. We conclude that detected vulnerabilities regarding age-related recreation in cities are anchors to mainstream the issue and enhance future planning practices and research.
Health Disparities between Religious Majority and Minority: A Cross-National Analysis
Authors: Lu Yun , Yang Xiaozhao Y. 
Published: December 2022

Background Scholars have found that as a multi-facet phenomenon, religion has a complicated relationship with people's health well-being. However, current research on health and religion has left a vacuum in understanding why we observe widespread health disparities between the majority and minority religious groups. Purpose The present study is aimed at two purposes. First, we conduct a cross-national comprehensive examination of the relationship between religious minority/majority status and self-rated health. Second, we investigate the moderating potential of political contexts on the relationship in question. Methods Drawing from the 2010–2014 wave of World Values Survey, we construct an analytic sample containing about 70,000 individual cases nested within 51 countries, and apply multilevel modeling to account for the hierarchical data structure. Results We first find that religious minorities are less likely to report good/very good health status relative to members of majority group. However, we note that the religious minority health disadvantage is driven by a few country outliers. After exclusion of any of these country outliers from the analysis, there is no significant health difference between majority and minority groups. Moreover, we find that political contexts moderate the health effect of being a religious minority. In countries with low levels of democracy or heavy religious restriction on minority groups, people of minority groups are less likely to report good/very good health compared with those belonging to majority group. By contrast, in societies with high levels of democracy or low levels of religious restriction, the health dispartities between religious majority and minority groups become non-significant. A series of sensitivity analysis, including using multiple-imputation sample and different ways of coding key variables, provides credibility to the results. Conclusions and Implications This study's findings suggest that religious minorities experience health disadvantage, only when minority groups are denied of political and religious freedom. Compared with past works that mostly focused on a single or a few societies, this study provides large-scale, cross-national evidence for the issue of religious minority health. This study also adds to our understanding of how political context shapes the health impacts of religion.
2022 ASSBI PRESIDENTIAL ADDRESS. Reflections on language and primary progressive aphasias
Authors: Piguet Olivier 
Published: December 2022

AbstractPrimary progressive aphasias are rare younger-onset dementias. As the label denotes, these dementias are characterised clinically by marked changes in language skills. Evidence over the years has shown that individuals with primary progressive aphasia experience widespread cognitive and behavioural changes that extend beyond language. This evidence, however, seems to be largely ignored or downplayed. This article proposes that linguistic relativity which induces a cognitive bias may be responsible for this omission; it also indicates that a revision of the current diagnostic criteria may need to be revised.
The Epistemic Significance of Social Pressure
Authors: Joshi Hrishikesh 
Published: December 2022

AbstractThis paper argues for the existence of a certain type of defeater for one’s belief thatP—the presence of social incentives not to share evidence againstP.Such pressure makes it relatively likely that there is unpossessed evidence that would provide defeaters forPbecause it makes it likely that the evidence we have is a lopsided subset. This offers, I suggest, a rational reconstruction of a core strand of argument in Mill’sOn Liberty.A consequence of the argument is that on morally and politically laden issues in particular, a high degree of doxastic openness might be appropriate.
Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase
Authors: Sánchez Begoña , Muñoz-Pinto Mario F. , Cano Mercedes 
Published: December 2022

Abstract
Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which has led to an increase in age-associated diseases. Therefore, it is crucial to study the process of ageing to guarantee the best conditions in the final stages of life. In recent years, interest has increased in a myokine known as irisin, which is secreted during physical exercise. This polypeptide hormone is produced by various organs, mainly muscle, and once it is released into the blood, it performs a wide variety of functions that are involved in metabolic control and may be relevant during some of the diseases associated with ageing. The aim of this review is to highlight the recent studies of irisin, such as its mechanism of expression, blood release, distribution, tissue target and participation in various cellular metabolic reactions and the relationship with key anti-ageing pathways such as adenosine monophosphate-activated protein kinase, silent information regulator T 1, autophagy and telomerase. In conclusion, irisin is a key player during the ageing process and it could be a novel target molecule for the therapeutic approach to boost longevity pathways. However, more research will be necessary to use this promising hormone for this gain.
Reading in Crisis: Francis Russell's Reading Records and the Beginnings of the Thirty Years’ War
Authors: Verweij Sebastiaan 
Published: December 2022

AbstractThis essay discusses the reading records of Francis Russell, 1587–1641, later 4th Earl of Bedford. Drawing from a previously unstudied manuscript notebook from 1620 to 1622, the author demonstrates the importance of Russell's private archive at Woburn Abbey as an important repository for political, literary, and cultural history in the early Stuart age. The notebook evidences how a nobleman of Russell's wealth, stature, and influence prepared for political office, and more broadly, how he educated himself. The notebook contains a wide variety of texts, among them histories, sermons, poetry, political pamphlets, treatises, news, and gossip, much of which Russell brought to bear on the acute political Bohemian crisis then emerging, and on its consequences for domestic politics (for example, the 1621 Parliament). The notebook's contents also reveal more about early modern reading practice and the organization of knowledge and suggest the many networks of circulation through which Russell acquired his books, manuscript tracts, and oral information.
Binders Full of Judges: A Model of the Interdependency of Appointments to the United States Federal Judiciary
Authors: Uribe-McGuire Alicia 
Published: December 2022

AbstractIn this paper, I create a simulation model that predicts the portfolio of judges the president chooses to fill vacancies in the judiciary. I find that the president’s strategy in terms of appointments depends on constraint from the Senate, the talent pool of possible judges to appoint, the ideology of the courts in the judiciary, and the number of vacancies to be filled. The model is successful in replicating results that have been found in previous research, while also generating new hypotheses about previously unexplored aspects of the appointment process.
Gut microbiota alterations in stable outpatients with schizophrenia: findings from a case–control study
Authors: Misiak Błażej , Piotrowski Patryk , Cyran Agnieszka , Kowalski Krzysztof , Samochowiec Jerzy , Jabłoński Marcin , Plichta Piotr , Łaczmański Łukasz , Żebrowska Paulina , Kujawa Dorota , Łoniewski Igor , Kaczmarczyk Mariusz 
Published: December 2022

AbstractObjective:The pathogenesis of schizophrenia is multidimensional and intensively studied. The gut–brain axis disturbances might play a significant role in the development of schizophrenia.Methods:We compared the gut microbiota of 53 individuals with schizophrenia and 58 healthy controls, using the 16S rRNA sequencing method. Individuals with schizophrenia were assessed using the following scales: the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, the Social and Occupational Functioning Assessment Scale and the Repeatable Battery for the Assessment of Neuropsychological Status.Results:No significant between-group differences in α-diversity measures were observed. Increased abundance of Lactobacillales (order level), Bacilli (class level) and Actinobacteriota (phylum level) were found in individuals with schizophrenia regardless of potential confounding factors, and using two independent analytical approaches (the distance-based redundancy analysis and the generalised linear model analysis). Additionally, significant correlations between various bacterial taxa (the Bacteroidia class, the Actinobacteriota phylum, the Bacteroidota phylum, the Coriobacteriales order and the Coriobacteria class) and clinical manifestation (the severity of negative symptoms, performance of language abilities, social and occupational functioning) were observed.Conclusions:The present study indicates that gut microbiota alterations are present in European patients with schizophrenia. The abundance of certain bacterial taxa might be associated with the severity of negative symptoms, cognitive performance and general functioning. Nonetheless, additional studies are needed before the translation of our results into clinical practice.
Tips and tricks for maximising access to the middle cranial fossa using the superior lateral orbital portal
Authors: Patel T A , Mustak H , Lubbe D E 
Published: December 2022

AbstractBackgroundTransorbital endoscopic approaches are becoming increasingly popular for skull base pathologies; the superior lateral orbital portal is one such approach to the middle cranial fossa. This paper provides a technical description that maximises the surgical portal and minimises morbidity.Technical descriptionA superior lid crease incision is made extending laterally and the orbital rim is exposed. A subperiosteal dissection of the lateral and superior orbit is performed, with elevation of periosteum off Whitnall's tubercle, ligation of the recurrent branch of the middle meningeal artery, and identification of the superior orbital fissure. The lacrimal keyhole is then drilled away. The middle cranial fossa is accessed by drilling posterior to the orbital rim to expose: the temporalis muscle anterior-laterally, the dura of the temporal lobe posterior-laterally, the anterior cranial fossa superiorly and the periorbita medially.ConclusionThese surgical steps can maximise the surgical portal and minimise morbidity, with avoidance of injury to surrounding structures.
Heavy episodic drinking in adolescence and alcohol-related problems in adulthood: A developmental approach to alcohol use across the life course
Authors: Wallace Gemma T. , Whichard Corey , Augustyn Megan , Henry Kimberly L. 
Published: December 2022

AbstractHeavy episodic drinking (HED) is a major public health concern, and youth who engage in HED are at increased risk for alcohol-related problems that continue into adulthood. Importantly, there is heterogeneity in the onset and course of adolescent HED, as youth exhibit different trajectories of initiation and progression into heavy drinking. Much of what is known about the etiology of adolescent HED and alcohol-related problems that persist into adulthood comes from studies of predominantly White, middle-class youth. Because alcohol use and related problems vary by race/ethnicity and socioeconomic status, it is unclear whether previous findings are relevant for understanding developmental antecedents and distal consequences of adolescent HED for minoritized individuals. In the current study, we utilize a developmental psychopathology perspective to fill this gap in the literature. Using a racially and economically diverse cohort followed from adolescence well into adulthood, we apply group-based trajectory modeling (GBTM) to identify patterns of involvement in HED from age 14 to 17 years. We then investigate developmental antecedents of GBTM class membership, and alcohol-related distal outcomes in adulthood (∼ age 31 years) associated with GBTM class membership. Results highlight the importance of adolescent alcohol use in predicting future alcohol use in adulthood.