bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-engineering a Clinical Trial Management System Using Blockchain Technology: System Design, Development, and Case Studies
Authors: Zhuang Yan , Zhang Luxia , Gao Xiyuan , Shae Zon-Yin , Tsai Jeffrey J P , Li Pengfei , Shyu Chi-Ren 
Published: May 2022

Background
A clinical trial management system (CTMS) is a suite of specialized productivity tools that manage clinical trial processes from study planning to closeout. Using CTMSs has shown remarkable benefits in delivering efficient, auditable, and visualizable clinical trials. However, the current CTMS market is fragmented, and most CTMSs fail to meet expectations because of their inability to support key functions, such as inconsistencies in data captured across multiple sites. Blockchain technology, an emerging distributed ledger technology, is considered to potentially provide a holistic solution to current CTMS challenges by using its unique features, such as transparency, traceability, immutability, and security.

Objective
This study aimed to re-engineer the traditional CTMS by leveraging the unique properties of blockchain technology to create a secure, auditable, efficient, and generalizable CTMS.

Methods
A comprehensive, blockchain-based CTMS that spans all stages of clinical trials, including a sharable trial master file system; a fast recruitment and simplified enrollment system; a timely, secure, and consistent electronic data capture system; a reproducible data analytics system; and an efficient, traceable payment and reimbursement system, was designed and implemented using the Quorum blockchain. Compared with traditional blockchain technologies, such as Ethereum, Quorum blockchain offers higher transaction throughput and lowers transaction latency. Case studies on each application of the CTMS were conducted to assess the feasibility, scalability, stability, and efficiency of the proposed blockchain-based CTMS.

Results
A total of 21.6 million electronic data capture transactions were generated and successfully processed through blockchain, with an average of 335.4 transactions per second. Of the 6000 patients, 1145 were matched in 1.39 seconds using 10 recruitment criteria with an automated matching mechanism implemented by the smart contract. Key features, such as immutability, traceability, and stability, were also tested and empirically proven through case studies.

Conclusions
This study proposed a comprehensive blockchain-based CTMS that covers all stages of the clinical trial process. Compared with our previous research, the proposed system showed an overall better performance. Our system design, implementation, and case studies demonstrated the potential of blockchain technology as a potential solution to CTMS challenges and its ability to perform more health care tasks.
Comparing the Use of a Mobile App and a Web-Based Notification Platform for Surveillance of Adverse Events Following Influenza Immunization: Randomized Controlled Trial (Preprint)
Authors: Bota A Brianne , Bettinger Julie A , Sarfo-Mensah Shirley , Lopez Jimmy , Smith David P , Atkinson Katherine M , Bell Cameron , Marty Kim , Serhan Mohamed , Zhu David T , McCarthy Anne E , Wilson Kumanan 
Published: May 2022

BACKGROUND

Vaccine safety surveillance is a core component of vaccine pharmacovigilance. In Canada, active, participant-centered vaccine surveillance is available for influenza vaccines and has been used for COVID-19 vaccines.

OBJECTIVE

The objective of this study is to evaluate the effectiveness and feasibility of using a mobile app for reporting participant-centered seasonal influenza adverse events following immunization (AEFIs) compared to a web-based notification system.

METHODS

Participants were randomized to influenza vaccine safety reporting via a mobile app or a web-based notification platform. All participants were invited to complete a user experience survey.

RESULTS

Among the 2408 randomized participants, 1319 (54%) completed their safety survey 1 week after vaccination, with a higher completion rate among the web-based notification platform users (767/1196, 64%) than among mobile app users (552/1212, 45%; <i>P</i>&lt;.001). Ease-of-use ratings were high for the web-based notification platform users (99% strongly agree or agree) and 88.8% of them strongly agreed or agreed that the system made reporting AEFIs easier. Web-based notification platform users supported the statement that a web-based notification-only approach would make it easier for public health professionals to detect vaccine safety signals (91.4%, agreed or strongly agreed).

CONCLUSIONS

Participants in this study were significantly more likely to respond to a web-based safety survey rather than within a mobile app. These results suggest that mobile apps present an additional barrier for use compared to the web-based notification–only approach.

CLINICALTRIAL

ClinicalTrials.gov NCT05794113; https://clinicaltrials.gov/show/NCT05794113
Approaches to forecasting of time dynamics of the processes and use of Farr’s epidemic evolution law on example of dynamics of new cases of HIV-infection in Russian Federation
Authors: Barinova A. N. , Lebedeva A. A. , Gusarov M. V. , Plavinskii S. L. 
Published: May 2022

Introduction. Forecasting of different processes in health, including epidemics, are important area of public health. There exists an idea that in some cases simple models can give adequate forecasts.Goal of this studywas to evaluate possible use and results of forecasting of registration of new cases of HIV infection in Russian Federation based on well-known Farr’s law.Materials and methods. The official statistical data on new HIV cases in 1999–2020 in Russian Federation were used. Parameters for forecasting new cases until 2027 were calculated according to Bregman and Langmuir. For evaluation of forecasting the calculations were done for 2015–2020 after fitting model with data until 2014. Normal components of the empirical epidemic curve were estimated and more appropriately fitted distributions were found for the data described by those components.Results. Estimations according to the Farr’s law somewhat undercount number of the new cases of HIV infection (it forecast 99% (95% CI 92–106%) cases when smoothing was used and 97% (95% CI 89–106%) when raw data were used). In general, especially when smoothing was used, fit was satisfactory. Forecast until 2027 show that total number of HIV cases in 1999–2027 will be 1.7–2.0 mln people. Analysis of most probable distribution of the second peak of epidemic curve show that it is lognormal, which allow for much larger number of infected in medium- and long-term perspective.Conclusion. Though Farr’s law could be used for short-term forecast it is not recommended to weaken preventive programs due to possibility of large increase in number of HIV-infected in comparison with Farr’s law forecast.
Prospects for the Study of Charlotte Perkins Gilman
Authors: KNIGHT DENISE D. 
Published: May 2022

Abstract
This essay examines the changing landscape in Gilman studies and suggests future directions that scholars might take to further our understanding of this often-enigmatic fin-de-siècle author. Since 2009, the Schlesinger Library at Radcliffe Institute has acquired a sizeable collection of new material from Gilman's descendants, including letters, photographs, inscribed books, miscellaneous documents, and numerous family keepsakes. The new material adds yet another layer to recovery efforts made in recent years. Scholars might continue to evaluate Gilman's mixed legacy, including her racism, classism, ethnocentrism, and support of eugenics. Future research might also continue to situate Gilman in a less nationalistic and more global context; her work continues to be compelling, as well as controversial, to readers and scholars well beyond the United States.
Eleven More Western Women Writers
Authors: BAYM NINA 
Published: May 2022

Abstract
Following Women Writers of the American West, 1833–1927 (2011), this essay surveys eleven neglected western women writers from all regions except California. In Texas, Maude Mason Austin wrote a borderlands novel and poetry, Gertrude Beasley described growing up poor, and Esther Darbyshire MacCallum recounted a church's history. In the plains, Mary A. Cragin (pseud. Joy Allison) and Lorna Doone Beers (Mrs. C. R. Chambers) published novels. In the Pacific Northwest, Sidona V. Johnson and Georgiana Mitchell Blankenship brought out regional histories. Regarding the Southwest, Harriet S. Kellogg memorialized Emily J. Harwood, Julia H. Johnston focused on Indians and Mexicans without having lived in the West, and Katharine Roney Crowell published religious school texts. Finally, Katharine Coman attempted to encapsulate the progress of the entire West. This survey concludes with commentary on Willa Cather, who shared these writers' sense that (white) women had allowed the West to fulfill its destiny.
“Stepchild of the Sun”: An Unpublished Story by Susan Glaspell
Authors: ROESSEL DAVID , WERTZBERGER STEVEN R. 
Published: May 2022

Abstract
The previously unpublished story “Stepchild of the Sun” by American playwright and novelist Susan Glaspell deals with the exclusionary nature of female community and its complicated relationship with female solidarity. The story is about a woman named Maida who contracts a rare disease that precludes her from ever being in sunlight again. It details Maida's life after contracting the disease and the problems her condition causes both in her relationships with friends and in her inner life. The typescript with the author's handwritten corrections is located in the Berg Collection of the New York Public Library.
Avoiding “the stench of the ego”: An Interview with Andre Dubus III
Authors: Dubus Andre , EDENFIELD OLIVIA CARR 
Published: May 2022

Abstract
This interview with Andre Dubus III, award-winning novelist and essayist, took place in Newburyport, MA, on July 11, 2011, only a few months after the publication of his memoir, Townie. The interviewer is the authorized biographer of Andre Dubus, the critically acclaimed short-story writer and Andre III's father. Dubus discusses the writing process, his literary influences, and the struggles of writing memoir. He is frank in regards to the determination required to face his past, troubled as it was due to his father's absence. This particular discussion is most noteworthy for his realization, which took place during the interview, that memoir, not fiction, was the only genre that he could use to tell his life story with authenticity and integrity.
Steinbeck's Last Words
Authors: SHILLINGLAW SUSAN 
Published: May 2022

Abstract
Steinbeck's “last words” were about the war in Vietnam. Written in 1966–67, Steinbeck's Vietnam dispatches were published in newspapers across America as “Letters to Alicia” and have been collected for the first time in Steinbeck in Vietnam: Dispatches from the War, edited by Thomas Barden. In a lucid introduction and afterword, Barden explains why the ailing Steinbeck, whose son John was serving in Vietnam, felt compelled to witness this unpopular war for himself. While Steinbeck's “last words” are far from his best, they nonetheless offer captivating evidence of a writer who cared deeply about his country's stake in the world.
Crossing the 38th Parallel
Authors: PURCELL RICHARD 
Published: May 2022

Abstract
This review-essay contextualizes Timothy Parrish's most recent book, Ralph Ellison and the Genius of America (2012), within the cultural politics that have defined the critical reception of Ralph Waldo Ellison's writings, especially his most famous novel, Invisible Man (1952). This review-essay suggests that, even as it takes Ellison scholarship in new and exciting directions, Parrish's book reminds us of how Ellison's work is still used by critics to engage in a continuation of the culture wars.
The Crisis of Beat Studies Scholarship
Authors: GRACE NANCY M. 
Published: May 2022

Abstract
The review-essay considers Capturing the Beat Moment: Cultural Politics and the Poetics of Presence, by Erik Mortenson, as a vehicle not only to assess Mortenson's text but also to explore the current state of the field of Beat studies. Specifically, this review-essay addresses the roles of graduate programs, the early reputation of Beat writers as nonacademic no-nothings, the quality of seminal studies of Beat literature, and the popular and academic publishing worlds—all of which have contributed to an erosion of scholarly standards in the field.
Prospects for the Study of H.D.
Authors: DEBO ANNETTE 
Published: May 2022

AbstractThis essay looks to the future of literary scholarship about modernist writer H.D. (Hilda Doolittle). Readers can now easily obtain almost all of H.D.'s writings—which remained, for decades, ensconced in the archives—and the question becomes what else is needed in H.D. studies. New biographies are desperately needed, and edited volumes of letters are the logical complement to the biographies. Digitization of H.D.'s papers, which has begun, would make materials increasingly available to scholars, established and new. Editions are still needed for a few texts, and scholarly editions would assist our understanding of the most important works. Electronic tools are being developed and need financial support for development and publication, and the more traditional venues of selected essay volumes, reference books, and journal special issues are called for. Additionally, as the volume of scholarly work on H.D. increases, we need new critical lenses through which to read her writing.
Tall Tales and Raw Realities: Late-Stage Deletions from Cormac McCarthy's “Suttree”
Authors: LUCE DIANNE C. 
Published: May 2022

Abstract
After Cormac McCarthy submitted his final draft of Suttree to Random House in 1977, editor Albert Erskine asked him to condense the book, eliminate dull dialogue, and clarify his view of his protagonist. Over a period of eight or nine months, McCarthy revised, deleting five episodes, four of which reflect his engagement with the narrative complexities and troubling cruelties of the Sut Lovingood yarns. Drawing on typescripts and correspondence, this article summarizes and analyzes the unpublished episodes, evaluates what each had contributed to the novel and what was gained and lost when McCarthy deleted them. His revision process did little to make his attitudes toward Suttree more explicit, but it reduced the distasteful realism of the novel, sacrificed a few plot connections, abandoned interesting (if not always successful) material relating to oral storytelling and its transformation into literary storytelling, and reduced the indications that Suttree is a writer in the making.
Six Early James Fenimore Cooper Letters
Authors: FRANKLIN WAYNE , Cooper James 
Published: May 2022

Abstract
Very few letters written by James Fenimore Cooper survive from the period prior to the start of his literary career in 1820. The present article provides the annotated texts of six newly discovered letters dating from between 1817 and 1820, all of which concern the financial crisis that then was confronting the estate of Cooper's father. Five of the letters were addressed by James Cooper to a young lawyer, Thomas Bridgen, who created that crisis by his efforts to recover debts the Coopers owed his own family. Because Bridgen and young Cooper apparently had been acquainted as schoolboys early in the 1800s, their later dealings over financial matters were strongly colored by personal feelings. Bridgen's eventual betrayal of Cooper gave the story a peculiarly poignant tone that is audible, I argue, in several loosely autobiographical novels that Cooper published in the 1840s.
“I am constructing a legend”: Ernest Hemingway in Guy Hickok's Brooklyn “Daily Eagle” Articles
Authors: TROGDON ROBERT W. , Hickok Guy 
Published: May 2022

Abstract
In April of 1927, Ernest Hemingway traveled to Italy with Guy Hickok, Paris correspondent for the Brooklyn Daily Eagle. Hemingway's “Che Ti Dice La Patria?” includes Hickok as a character. What is less well known is Hickok's writing on Hemingway. Between 1925 and 1934, Hickok wrote sixteen articles that either mention Hemingway or deal wholly with his life and work. In this essay, six of these dispatches and interviews are reprinted; these include an account of Hemingway's wounding during World War I, descriptions of Hemingway in Pamplona in 1929, and an extensive interview about Hemingway's 1933–34 African safari.
The Invention of Viking America
Authors: BAUER RALPH 
Published: May 2022

Abstract
This essay is an extended review of Annette Kolodny's In Search of First Contact: The Vikings of Vinland, the Peoples of the Dawnland, and the Anglo-American Anxiety of Discovery (Durham, NC: Duke University Press, 2012). The 448-page paperback includes ten illustrations and is priced at $27.95.
Pengelolaan Sarana Prasarana dalam Implementasi Kurikulum Pendidikan Guru Sekolah Dasar: Sebuah Studi Kasus di Universitas Negeri Semarang
Authors: Setyaningih Sri 
Published: May 2022

Pengembangan kurikulum di Perguruan Tinggi khususnya pada Program StudiPendidikan Guru Sekolah Dasar (PGSD) di Universitas Negeri Semarang (UNNES)pada prinsipnya menyesuaikan dinamika dan perubahan dalam masyarakat.Penelitian ini bertujuan untuk mendeskripsikan pengelolaan sarana dan prasaranaProgram Studi PGSD di UNNES ditinjau dari: perencanaan, pemanfaatan, dan perawatan. Penelitian menggunakan pendekatam kualitatif dengan informan KetuaProgram Studi dan perwakilan beberapa dosen PGSD. Teknik pengumpulan data meliputi: 1) observasi partisipan; 2) wawancara mendalam; dan 3) studi dokumen.Analisis data digunakan model interaktif dengan prosedur: reduksi data, sajiandata, dan penarikan simpulan/verifikasi. Adapun keabsahan data dilakukan melalui pengechekan yang berdasar pada 4 (empat) ukuran, yaitu: 1) tingkat kepercayaan; 2)keteralihan; 3) ketergantungan; dan 4) kepastian. Hasil penelitian menunjukkan: 1)perencanaan sarana prasarana mengacu pada alokasi anggaran dan kebutuhan yangefektif dan responsif terhadap kebutuhan pendidikan, minimal telah menyediakanlingkungan fisik yang nyaman, aman, mudah diakses, laboratorium komputer,laboratorium bahasa, laboratorium IPA, dministrasi yang terkoordinir dengan baik;2) pemanfaatan sarana prasarana mampu menunjang kegiatan Program Studi yangdidasarkan pada kebutuhan dan tuntutan institusi, baik untuk mahasiswa, dosen,maupun pihak lain yang bekerjasama sehingga ada kemitraan; dan 3) perawatansarana prasarana dilakukan berkesinambungan dalam kegiatan Program Studiyang didukung oleh kegiatan penjagaan atau pencegahan dari kerusakan suatubarang, sehingga suatu barang kondisinya dalam keadaan baik dan siap digunakan.Pemeliharaan dimulai pemakaian barang secara hati-hati, termasuk membersihkansemua alat dan media pembelajaran dan perkantoran.
Manajemen Kurikulum dan Pembelajaran Komputer dan Jaringan Dasar di SMK
Authors: Awalludin Nur , Fuadi Djalal 
Published: May 2022

Penelitian ini bertujuan untuk (1) Mendiskripsikan Perencanaan KurikulumPembelajaran Komputer dan Jaringan dasar di SMK Negeri 2 Sragen. (2)Mendiskripsikan Pelaksanaan Pembelajaran Komputer dan Jaringan dasar di SMKNegeri 2 Sragen. (3) Mendiskripsikan Penilaian Kurikulum Komputer dan Jaringandasar di SMK Negeri 2 Sragen.Penelitian ini menggunakan metode penelitiankualitatif yang dilakukan di SMK Negei 2 Sragen. Subyek utama dalam penelitianadalah kepala sekolah dan guru. Teknik pengumpulan data yang dipergunakan dalampenelitian ini adalah observasi, wawancara dan dokumentasi. Teknik analisis datadalam penelitian ini menggunakan model analisis yaitu pengumpulan data, reduksidata, dan penyajian data serta kesimpulan. Keabsahan data dalam penelitian dengan trianggualsi.Hasil dari penelitian ini adalah: (1) perencanaan pembelajaran Komputerdan Jaringan Dasar di SMK Negeri 2 Sragen dilaksanakan dengan cara menyiapkanperangkat pembelajaran berupa, Silabus, Program Tahunan, Program Semester danrancangan pelaksanaan pembelajaran (RPP). (2) Pelaksanaan pembelajaran Komputerdan Jaringan Dasar di SMK Negeri 2 Sragen dilaksanakan dengan menggunakanberbagai macam metode pembelajaran. Metode pembelajaran yang digunakan antaralain model pembelajaran dengan ceramah, diskusi kelompok, demonstrasi sertasimulasi. Peran guru dalam pembelajaran Komputer dan Jaringan Dasar sebagaifasilitator, sedangkan siswa berperan aktif dalam proses pembelajaran. (3) penilaiankurikulum Komputer dan Jaringan Dasar dilaksanakan oleh kepala sekolah melaluikegiatan supervisi untuk mengetahui ketercapaian kurikulum serta sebagai acuandalam melakukan tindak lanjut perbaikan.
Peran Kepuasan Kerja Sebagai Mediator Keadilan Organisasi dan Motivasi Kerja Terhadap Kinerja Guru
Authors: Sudibjo Niko , Ananta Aluysius Songky 
Published: May 2022

Educational institution such as schools rely heavily on the performance of their teachers in implementing educational practices. Therefore, it is very important for educational institution in managing the teachers’ performance. Factors that are thought to affect performance include organizational justice, motivation and job satisfaction. Therefore, this study aims to examine the effect of organizational justice, work motivation, and job satisfaction on perceptions of the performance of 64 teachers in XYZ junior dan senior high school. The research data obtained were analyzed using a quantitative approach with the PLS-SEM method. The research instrument, a questionnaire to measure the impact of four variabels. The results of this study showed that organizational justice, work motivation and job satisfaction have a positive effect on the performance of XYZ Middle and High School teachers. Job satisfaction variabels succeeded in mediating the effect of work motivation on teacher performance, but on the other hand, job satisfaction did not succeed in mediating the effect of organizational justice on teacher performance.
Gender Equality in Media Television (Semiotics Analysis of Fair and Lovely Advertisement Issue of Marriage or Master Degree)
Authors: Dwita Desliana 
Published: May 2022

In many developing countries, most of television advertisements portray a general perception of patriarchy where men take decision for women and no place for gender equality. This work describes an analysis on a courageous “Fair and Lovely” advertisement in Indonesia that conveys the message of gender equality. A semiotics analysis, qualitative–interpretative method, was used to analysis the signs related to gender equality messages in the episode about choosing between marriage and master degree. It is found that a women was pictured as someone who is confident, expressed bold opinions, like to discuss and exchange ideas, firm and straight forward in speaking, and wise in making a decision. In general, the visual signs used in the “Fair and Lovely” advertisement convey a message that women should be equal with men especially in education and careers. Keywords :Advertisement, Gender Equality, Semiotic Analysis Roland Barthes.
Obtaining and Characterizing the Pb(Mg1/3Nb2/3)O3–Ln(Mg1/2Ti1/2)O3 Doped System
Authors: Dumitru Alina Iulia 
Published: May 2022

Abstract
The Pb(Mg1/3Nb2/3)O3-based ceramic system was obtained by using a modified variant of the conventional ceramic method in order to get pyrochlore-free compositions. Solid solutions obtained from Pb(Mg1/3Nb2/3)O3 and Ln(Mg1/2Ti1/2)O3 with Ln = Y3+, La3+, Pr3+, Nd3+ and Sm3+, were synthesized using a 3-step columbite precursor method and appropriate milling and sintering conditions. The structural phases of all sintered compositions were investigated in detail. The X-ray diffraction results demonstrate that all the samples possess a perovskite structure. The influence of dopant on the incorporation degree in the solid solutions was studied. The dielectric constants at three frequencies were measured and the influence of the dopant on these values was discussed.