bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Exposure to Effervescent Paracetamol and Hospitalization for Acute Heart Failure: A Case‐Crossover Study
Authors: Perrin Germain , Arnoux Armelle , Berdot Sarah , Katsahian Sandrine , Danchin Nicolas , Sabatier Brigitte 
Published: January 2022

AbstractWe investigated whether effervescent paracetamol, as an important source of nondietary sodium and fluid load, is associated with a transient increase in the risk of hospitalization for acute heart failure (AHF). We conducted a unidirectional case‐crossover study using data from the 1 in 97th representative sample from the French health care database. Subjects aged ≥18 years, hospitalized for AHF during the 2014‐2016 period, were included. Exposure to effervescent paracetamol was compared between a risk period (ie, 15 days immediately before admission for AHF) and 3 earlier 15‐day control periods, to test a possible trigger effect of effervescent paracetamol intake on AHF. Adjusted odds ratios (aORs) were estimated with a conditional logistic regression. We identified 4301 patients hospitalized for AHF. We found that 5.7% of AHF subjects were exposed to effervescent paracetamol during the risk period, as compared with 4.1% during the control periods (aOR, 1.56 [95% confidence interval [CI], 1.27‐1.90]; P < .001). This association was also found in the subgroup of subjects with hypertension (aOR, 1.45 [95%CI, 1.13‐1.87]; P = .004, n = 2648) and in the subgroup of subjects aged ≥83 years (aOR, 1.70 [95%CI: 1.28‐2.24], P < .001, n = 2238). A similar analysis, considering exposure to noneffervescent paracetamol, did not support the existence of an indication bias likely to explain the association observed for effervescent paracetamol. This study suggests an association between effervescent paracetamol and admission for AHF and should be confirmed with other complementary study designs.
Thoracic ultrasound competence for ultrasound guided pleural procedures: The creation and validation of an assessment tool for use in the certification of basic thoracic ultrasound competence
Authors: McCracken David J. , Bedawi Eihab O. , Stevenson Michael , Cullen Kathy M. , Stanton Andrew E. , Rahman Najib M. 
Published: January 2022

AbstractObjectivesFocused thoracic ultrasound (TUS) provides an increased safety profile when undertaking invasive pleural procedures. This has led to the requirement for defined curricula, high quality teaching and robust, validated assessment tools among physicians to ensure patient safety and clinical excellence.Current UK practice is based almost exclusively on expert consensus, but assessment methods employed have been shown to have low reliability and validity and are potentially open to bias. As a result, several assessment tools have been developed, although each has its own limitations.MethodsThis study aimed to develop and validate an assessment tool corresponding to those skills associated with the most basic level of practice, defined recently as an emergency level operator in the British Thoracic Society Training Standards for Thoracic Ultrasound.ResultsA total of 27 candidates were enrolled by two examiners based in Belfast and Oxford over a 10‐month period between February and November 2019. Mean score of the inexperienced group was 44.3 (95% CI 39.2–49.4, range 28–54) compared with 74.9 (95% CI 72.8–77, range 64–80) in the experienced group providing an estimated mean difference of 30.7 between the two groups (95% CI 24.7–36.7; p < .001).ConclusionsThis tool appears to discriminate between trainees with limited experience of TUS performance and those with no experience. It has the potential to form part of the assessment strategy for trainees in the United Kingdom and beyond, alongside well established assessment tools in postgraduate training.
Daratumumab combined with dexamethasone and lenalidomide or bortezomib in relapsed/refractory multiple myeloma (RRMM) patients: Report from the multiple myeloma GIMEMA Lazio group
Authors: Fazio Francesca , Franceschini Luca , Tomarchio Valeria , Rago Angela , Garzia Maria Grazia , Cupelli Luca , Bongarzoni Velia , Andriani Alessandro , Gumenyuk Svitlana , Tafuri Agostino , Siniscalchi Agostina , Piciocchi Alfonso , De Fabritiis Paolo , De Rosa Luca , Caravita di Toritto Tommaso , Annibali Ombretta , Cantonetti Maria , Petrucci Maria Teresa 
Published: January 2022

AbstractThe multiple myeloma (MM) treatment has changed over the last years due to the introduction of novel drugs. Despite improvements in the MM outcome, MM remains an incurable disease. Daratumumab is a human IgGK monoclonal antibody targeting CD38 with tumor activity associated with immunomodulatory mechanism. In combination with standard of care regimens, including bortezomib (Vd) or lenalidomide (Rd), daratumumab prolonged progression‐free survival (PFS) in patients (pts) with relapsed/refractory multiple myeloma (RRMM) and in new diagnosis MM. We report the data of the MM GIMEMA Lazio group in 171 heavily treated pts who received daratumumab, lenalidomide and dexamethasone (DRd) or daratumumab, velcade and dexamethasone (DVd). The overall response rate was 80%, and the overall survival (OS) and PFS were 84% and 77%, respectively. In addition, pts treated with DRd showed a better median PFS compared to pts treated with DVd, at 12 and 24 months, respectively. The most common hematologic treatment‐emergent adverse events (TAEs) were neutropenia, thrombocytopenia, and anemia. The most common nonhematologic TAEs were peripheral sensory neuropathy and infections. Our data confirmed that DRd or DVd therapy is effective and safe in RRMM pts, and our real‐life analysis could support the physicians regarding the choice of optimal therapy in this setting of pts.
Is it safe and efficacious to remove central lines in pediatric bone marrow transplant patients with platelets less than 20,000/μl?
Authors: Marwah Priya , Ramprakash Stalin , Prasad T R Sai , Gizhlaryan Mane , Trivedi Deepa , Shah Vaibhav , Chitaliya Amit , Elizabeth Sandeep , Agarwal Rajat Kumar , Dhanya Rakesh , Faulkner Lawrence 
Published: January 2022

AbstractBackgroundPatients with tunneled central venous lines (CVL) may develop bloodstream infections which at times are difficult to control without line removal. Concomitant severe thrombocytopenia with platelet transfusion refractoriness is often considered a major contraindication to any procedure involving a major blood vessel. There is very little literature on the clinical risks of tunneled central line removal in febrile pancytopenia patients.ProcedureWe analyzed complications and outcomes in all our patients, a total of 52, who underwent CVL removal with platelets <20,000/μl.ResultsCVL removal was done on a median day of 17.5 with 47 of the 52 patients never having achieved platelets engraftment prior to line removal. No bleeding episodes or unplanned transfusions could be associated with CVL removal. No other complications were also reported. All patients had time to hemostasis within 5 min of catheter removal. Removal of CVL under local anesthesia remained complication‐free even at platelet counts less than 20,000/ul. A total of 31 patients were febrile at the time of CVL removal, of which 17 became afebrile within 2 days. We found no difference in defervescence when comparing those whose antibiotic therapy was changed/escalated versus those in whom it was not.ConclusionOur findings suggest that central lines can be safely removed with platelet counts less than 20,000/ul and that this may result in enhanced bloodstream infection control. This might be particularly relevant to neutropenic patients in this day and age of multidrug‐resistant organism emergence and paucity of new effective antibiotics.
Revised prognostic indicators for treatment of lymph node positive colorectal peritoneal metastases
Authors: Sugarbaker Paul H. , Chang David 
Published: January 2022

AbstractBackgroundPeritoneal metastases from colon and rectal cancer presents a new target for a regional approach to treatment. Proper patient selection requires an understanding of the natural history of the disease progression.MethodsData from colorectal cancer patients treated for peritoneal metastases by cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy and early postoperative intraperitoneal chemotherapy and the records from the primary colon or rectal cancer surgery were analyzed to assess their impact on survival. Data regarding the anatomic sites of colorectal peritoneal metastases was gathered at the time of a complete CRS.ResultsA cohort of 73 patients with peritoneal metastases and lymph node metastases but no liver metastases provided the information. All patients had a complete cytoreduction. Left‐sided primary cancer and a complete or near complete response to neoadjuvant chemotherapy (NAC) indicated improved survival. Tumor progression within the abdominal incision, carcinoembryonic antigen (CEA) >10, peritoneal cancer index >9 and peritoneal metastases present in the abdominopelvic regions 6 and 11 carried an especially guarded prognosis.ConclusionsReduced survival occurred with a right‐sided or rectal primary cancer, a CEA >10, tumor cell entrapment, and involvement of abdominopelvic regions 6 and 11. Effective NAC showed a favorable outcome.
Multiresolution residual deep neural network for improving pelvic CBCT image quality
Authors: Wu Wangjiang , Qu Junda , Cai Jing , Yang Ruijie 
Published: January 2022

AbstractPurposeCone‐beam computed tomography (CBCT) is frequently used for accurate image‐guided radiation therapy. However, the poor CBCT image quality prevents its further clinical use. Thus, it is important to improve the HU accuracy and structure preservation of CBCT images.MethodsIn this study, we proposed a novel method to generate synthetic CT (sCT) images from CBCT images. A multiresolution residual deep neural network (RDNN) was adopted for image regression from CBCT images to planning CT (pCT) images. At the coarse level, RDNN was first trained with a large amount of lower resolution images, which can make the network focus on coarse information and prevent overfitting problems. More fine information was obtained gradually by fine‐tuning the coarse model using fewer number of higher resolution images. Our model was optimized by using aligned pCT and CBCT image pairs of a particular body region of 153 prostate cancer patients treated in our hospital (120 for training and 33 for testing). Five‐fold cross‐validation was used to tune the hyperparameters and the testing data were used to evaluate the performance of the final models.ResultsThe mean absolute error (MAE) between CBCT and pCT on the testing data was 352.56 HU, while the MAE between the sCT and pCT images was 52.18 HU for our proposed multiresolution RDNN model, which reduced the MAE by 85.20% (p < 0.01). In addition, the average structural similarity index measure between the sCT and CBCT was 19.64% (p = 0.01) higher than that of pCT and CBCT.ConclusionsThe sCT images generated using our proposed multiresolution RDNN have higher HU accuracy and structural fidelity, which may promote the further applications of CBCT images in the clinic for structure segmentation, dose calculation, and adaptive radiotherapy planning.
Utilization of Live-Food Enrichment with Polyunsaturated Fatty Acids (PUFA) for the Intensive Culture of Yellow Perch Larvae
Authors: Grayson John D. , Dabrowski Konrad 
Published: January 2022

Abstract
Challenges associated with first feeding have impeded the intensive culture of larval Yellow Perch Perca flavescens. Live-food enrichment with polyunsaturated fatty acids (PUFAs) can increase the growth and survival of larval fish, but this method has not been tested with Yellow Perch. This study includes two experiments that were meant to evaluate (1) the relative proportion of docosahexaenoic acid (DHA; 22:6[n-3]) and arachidonic acid (ARA; 20:4[n-6]) in enrichment emulsions and (2) the provision of PUFA emulsions in ethyl ester (EE) or triacylglycerol (TG) form on Yellow Perch growth and survival. Fish were provided with live rotifers Brachionus plicatilis and brine shrimp Artemia nauplii for the first 10 d of exogenous feeding within a specialized recirculating system (phase I). Fish were then transferred to flow-through tanks and were fed Artemia nauplii for 3 d before gradually transitioning to a formulated starter diet (5–7 d; phase II). Fish size, growth, survival, swim bladder inflation rates, and lipid/fatty acid concentrations were evaluated after each phase. Overall, rotifers assimilated ARA in higher concentrations (23.3% of total fatty acids) than Artemia (0.6–0.7% of total fatty acids). Rotifers also tended to assimilate PUFAs better in EE form than in TG form (71.3% versus 66.5% Σn-3 + n-6 fatty acids). In the first experiment, fish from the ARA- and DHA-enriched diet groups had greater swim bladder inflation rates (phase I) and growth rates (phase II) than the unenriched control group. In phase I of the second experiment, the EE enrichment group had a significantly faster growth rate than the TG enrichment group (specific growth rate: mean ± SD = 40.5 ± 0.9% and 36.6 ± 1.8%, respectively). Fatty acid composition of zooplankton was heavily influenced by enrichments, and fatty acid composition of larvae/juveniles reflected that of their live prey. The results of this study suggest that PUFA enrichment of live feeds can accelerate Yellow Perch growth and reduce the time spent in the critical period of early development.
Similar Environmental Conditions are Associated with Walleye and Yellow Perch Recruitment Success in Wisconsin Lakes
Authors: Brandt Ethan J. , Feiner Zachary S. , Latzka Alexander W. , Isermann Daniel A. 
Published: January 2022

Abstract
Since the mid-2000s, recruitment of Walleye Sander vitreus in some northern Wisconsin lakes has declined, potentially because of climate-induced changes in lake environments. Yellow Perch Perca flavescens is also an ecologically and culturally important fish species in this region, but mechanisms driving Yellow Perch recruitment are unclear because of a lack of targeted sampling. Previous studies have suggested that recruitment of these two species may be regulated by similar factors, and observed declines in Walleye recruitment may be cause for concern about Yellow Perch recruitment. Our objectives were to determine if abiotic factors related to recruitment success were similar between Walleye and Yellow Perch populations in northern Wisconsin lakes and if the probability of successful Walleye recruitment was related to estimates of juvenile Yellow Perch abundance before Walleye recruitment declines were observed. We addressed these objectives using historical data from Wisconsin lakes. Random forest analysis incorporating lake-specific averages of predictor variables indicated that winter conditions (duration or severity), growing degree days, variation in spring temperatures, peak summer temperature, and Secchi depth were important predictors of recruitment success for both species. Logistic regression indicated that before Walleye recruitment declines were observed on some lakes (2000–2006), Walleye recruitment success was related to relative abundance of juvenile Yellow Perch in mini-fyke-net sampling. Our results indicate that landscape-level patterns in recruitment success for the two species are likely similar and additional research to understand Yellow Perch recruitment trends is warranted. Better information on Yellow Perch recruitment could contribute to a better understanding of Walleye recruitment trends as declines in Yellow Perch could influence prey availability and survival of age-0 Walleye. Furthermore, potential declines in Yellow Perch could lead to changes in the numbers and size of Yellow Perch caught by anglers, which may have implications for harvest management.
The relations of inattention and hyperactivity to academic cheating in adolescents with executive functioning problems
Authors: Anderman Eric M. , Gilman Richard , Liu Xingfeiyue , Ha Seung Yon 
Published: January 2022

AbstractWe examine the relationships of executive functioning problems (EFP) to academic cheating in a sample of 855 adolescents. Participants completed assessments of inattention, hyperactivity, and depression using the BASC‐2, as well as peer‐reports of externalizing behavior. After controlling for known predictors of cheating (e.g., demographics and depression), multiple regression analyses indicated that inattention emerged as a predictor of greater cheating behaviors (R2 = 0.20). We also found that the positive relation between inattention and cheating was mediated by hyperactivity.
Risk factors for depression and anxiety during COVID‐19 in Israel: A two‐wave study before and during the pandemic
Authors: Gilbar Ohad , Gelkopf Marc , Berger Rony , Greene Talya 
Published: January 2022

AbstractResearch indicates that mental health problems increased across the globe after the outbreak of the COVID‐19 pandemic. However, there is a need for research examining specific risk factors for mental health problems, while accounting for symptoms before the pandemic. This study examined risk factors for depression and anxiety symptoms among Israeli adults following the first wave of the COVID‐19 pandemic in Israel, above and beyond depression and anxiety symptoms reported 3 years before the pandemic. We performed a two‐wave 3‐year longitudinal study (W1 July–September 2017; W2 May–June 2020). The final sample included 578 participants who completed anxiety and depression self‐report questionnaires at both waves. The W2 assessment additionally included being considered high‐risk for COVID‐19, and measures regarding loneliness, perceived stress, and COVID‐19 worries. Both anxiety and depression symptoms were significantly higher at W2 during the pandemic. Worries related to COVID‐19, perceived stress, loneliness, and prior mental health symptoms predicted depression and anxiety in W2. Additionally, being younger was associated with W2 anxiety. The current study highlights risk factors for psychological distress in light of the COVID‐19 pandemic. Attention of clinicians and policy makers should be given to the important role of loneliness when screening and treating people during this pandemic.
Asymmetrical organization of oral structures in the primary and secondary somatosensory cortices in rats: An optical imaging study
Authors: Kirihara Yuki , Zama Manabu , Fujita Satoshi , Ogisawa Shouhei , Nishikubo Shuichi , Tonogi Morio , Kobayashi Masayuki 
Published: January 2022

AbstractIn rodents, the representation of the body surface in the primary somatosensory cortex (S1) forms a mirror image along the ventral border of the S1 in the secondary somatosensory cortex (S2). Sensory information from the oral region is processed in the S1 and the border region between the S2 and insular oral region (IOR). We examined the relationship between somatosensory representations in the S1 and S2/IOR using optical imaging with a voltage‐sensitive dye in urethane‐anesthetized rats. In reference to the rhinal fissure and middle cerebral artery, we made a somatosensory map by applying electrical or air puff stimulation. The initial neural excitation in the S1 to facial structures, including the eyebrow, cornea, pinna, whisker pad, nasal tip, and nasal mucosa, spread toward the ventral area, putatively the S2. The initial cortical responses in the S1 to oral structures, including the lower lip, tongue, and teeth, were spatially separated from those in the S2/IOR. The representation of the tongue center, tongue tip, mandibular molar pulp, mandibular incisor pulp, and mandibular incisor periodontal ligament were almost linearly arranged from caudal to rostral in both S1 and S2/IOR. The lower lip was represented in the dorsal area from the representation of teeth and tongue in both S1 and S2/IOR. The representations of maxillary teeth were caudal and dorsal to the representations of mandibular teeth in the S1 and S2/IOR, respectively. These results suggest that the representation of oral structures in the S1 formed a non‐mirror image, not a mirror image, in the S2/IOR.
Scripting Analyses of Genomes in Ensembl Plants
Authors: Contreras-Moreira Bruno , Naamati Guy , Rosello Marc , Allen James E. , Hunt Sarah E. , Muffato Matthieu , Gall Astrid , Flicek Paul 
Published: January 2022

AbstractEnsembl Plants (http://plants.ensembl.org) offers genome-scale information for plants, with four releases per year. As of release 47 (April 2020) it features 79 species and includes genome sequence, gene models, and functional annotation. Comparative analyses help reconstruct the evolutionary history of gene families, genomes, and components of polyploid genomes. Some species have gene expression baseline reports or variation across genotypes. While the data can be accessed through the Ensembl genome browser, here we review specifically how our plant genomes can be interrogated programmatically and the data downloaded in bulk. These access routes are generally consistent across Ensembl for other non-plant species, including plant pathogens, pests, and pollinators.
CyVerse for Reproducible Research: RNA-Seq Analysis
Authors: Williams Jason 
Published: January 2022

AbstractPosing complex research questions poses complex reproducibility challenges. Datasets may need to be managed over long periods of time. Reliable and secure repositories are needed for data storage. Sharing big data requires advance planning and becomes complex when collaborators are spread across institutions and countries. Many complex analyses require the larger compute resources only provided by cloud and high-performance computing infrastructure. Finally at publication, funder and publisher requirements must be met for data availability and accessibility and computational reproducibility. For all of these reasons, cloud-based cyberinfrastructures are an important component for satisfying the needs of data-intensive research. Learning how to incorporate these technologies into your research skill set will allow you to work with data analysis challenges that are often beyond the resources of individual research institutions. One of the advantages of CyVerse is that there are many solutions for high-powered analyses that do not require knowledge of command line (i.e., Linux) computing. In this chapter we will highlight CyVerse capabilities by analyzing RNA-Seq data. The lessons learned will translate to doing RNA-Seq in other computing environments and will focus on how CyVerse infrastructure supports reproducibility goals (e.g., metadata management, containers), team science (e.g., data sharing features), and flexible computing environments (e.g., interactive computing, scaling).