bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults
Authors: Atila Cihan , Monnerat Sophie , Urwyler Sandrine Andrea , Refardt Julie , Winzeler Bettina , Christ-Crain Mirjam 
Published: May 2022

Abstract
Purpose Recently, non-osmotic tests such as glucagon, arginine or macimorelin stimulation were assessed for the ability to evaluated posterior pituitary function. Results showed that glucagon and arginine, but not macimorelin, stimulate copeptin secretion (as a surrogate marker of vasopressin) and, therefore, provide novel tests to assess the posterior pituitary. The exact underlying mechanism behind the stimulatory effect remain elusive.Methods This study combined data from three diagnostic studies conducted at the University Hospital Basel, Switzerland. In total, 80 healthy adults underwent the glucagon (n=22), arginine (n=30), and macimorelin (n= 28) stimulation test. The primary objective was to investigated glucose dynamics upon glucagon, arginine, and macimorelin stimulation tests and its effect on plasma copeptin release.Results Upon glucagon stimulation, the median [IQR] glucose level at baseline was 5.0 [4.6, 5.2] mmol/l, peaked to 8.1 [7.2, 9.4] mmol/l at 30 minutes and decreased to a minimum of 3.8 [3.5, 4.5] mmol/l at 120 minutes. The median copeptin increased upon glucagon stimulation by 7.6 [2.4, 28.0] pmol/l. Upon arginine, the glucose level at baseline was 4.9 [4.8, 5.5] mmol/l, peaked to 6.0 [5.2, 6.4] mmol/l at 30 minutes and decreased to a minimum of 4.3 [3.8, 4.8] mmol/l at 60 minutes. The median copeptin increased upon arginine stimulation by 4.5 [2.9, 7.5] pmol/l. Upon macimorelin, glucose levels showed no notable dynamics over the 120 minutes, and no major change in copeptin was observed. In the pooled dataset, a decrease in glucose levels was significantly correlated with copeptin increase (ρ= 0.49, p<0.001).Conclusion We demonstrate a similar course in plasma glucose after glucagon and arginine stimulation, while macimorelin had no effect on glucose levels, and show a strong correlation between the decrease in glucose levels and increase in copeptin after glucagon and arginine stimulation.
Experimental investigation to identify galaxy clusters using sparse matrix clustering algorithm
Authors: Rai Alok , Sen Snigdha , Chakraborty Pavan 
Published: May 2022

Abstract
Recent advances in astronomy have shifted observational astronomy toward data-driven astronomy, with an exponential increase in data associated with celestial objects. If we can handle this massive amount of quickly changing data, we will be able to detect galaxy clusters, revealing a wealth of vital information about the evolution of the universe. In this paper, we have proposed a novel clustering technique that can handle massive amounts of rapidly changing data in real time. In this clustering technique, we have used 3D sparse matrix where each cell of the 3D matrix can be used to locate/identify a neighbor against the central galactic coordinate. In our investigation, we also used HDF5 to store and organize the discovered galaxy clusters so that we didn’t have to re-run our algorithm every time a new coordinate was encountered. Following preparation, the astronomical data containing the galactic coordinates RA, DEC, and radial distance obtained from redshift is input into our developed algorithm to identify, store, and depict the galaxy clusters.
Expression and predictive functional profiles on MicroRNAs data in Vascularized Composite Allotransplantation Acute Rejection
Authors: Fang Yuan , Li Haibo , Chen Jingting , Xiong Yao , Li Xu , Sun Binbin , Li Shengli , Zhou Jianda , Wang Shoubao 
Published: May 2022

Abstract
Aim: To investigate the mechanisms of acute rejection for vascularized composite allotransplantation (VCA) using microRNAs (miRNAs) differential expression in a VCA animal model.Methods: Three brown Norway rats were used as transplant donors and three Lewis rats as VCA receptors. The changes were divided into different stages before and after transplantation in Lewis rats. The appearance changes of all subjects were recorded. Also, histological evaluations were performed on all recipients, and the microRNAs expression was analyzed when acute immune rejection occurred. Then, GO and KEGG Pathway analyses were employed to predict miRNA targets. Finally, differentially expressed miRNAs were detected by RT-qPCR.Results: Compared to pre-operation, 22 miRNAs were screened for significantly different expressions. Among them, nine were upregulated and 13 were downregulated in skin tissues. The RT-qPCR results revealed that rno-miR-340-5p and rno-miR-21-5p were significantly upregulated and enriched in the PI3K-Akt signaling pathway. Moreover, rno-miR-145-5p and rno-miR-195-5p were significantly downregulated, and most of their target genes were enriched in the Hippo signaling pathway. The histological evaluations showed that, after VCA, the skin tissue presented severe acute rejection.Conclusion: Overall, the miRNAs rno-miR-340-5p, rno-miR-21-5p, rno-miR-145-5p, and rno-miR-195-5p were significantly regulated during VCA acute rejection. These miRNAs are potential biomarkers for objective, early, and minimally invasive rejection diagnosis.
Evaluating plant micronutrient retention using an electric potential around the root zone in Rice (Oryza sativa L.) by using iron as an index ion
Authors: Senevirathne Gayathree I. , Chathurika J. A. S. , Gunwardana Manju , Siriwardhana Asitha S. , purasinhala Kosala 
Published: May 2022

Abstract
Deficiency in micronutrients lead to poor health and performance in plants and hidden hunger in many developing countries. Unavailability of micronutrients around the root zone is a major reason accounting for poor performance of crops. Especially, in rice, retention of plant nutrients is challenging due to water logged conditions and adding electric potential to retain nutrients would be a beneficial method to retain micronutrient around the root zone. Therefore, this study was designed to evaluate the effect of direct electric potential (EP) in retaining soil nutrient around the root zone using iron as an index ion. The experimental setup consisted of two concentric iron mesh pots, inner pot connected to the negative end and outer pot connected to the positive end. An electric potential of 5.0 V was supplied with the direct current of 0.1 A for 8 hours per day. Soil was characterized for available iron content around three zones at the time of panicle initiation and time of harvest using ICPMS plant growth and performance was measured. Soil-available Fe content was higher around the negative electrode than the positive electrode at the time of panicle initiation. Plant height, above ground biomass, and paddy yield were significantly lower in WEP plants than the NEP plants (P < 0.05). WEP plants showed a 45% reduction in paddy yield compared to the NEP plants. Results confirms that iron provided in the presence of an electric potential increases the iron concentration around the root zone and enhances the Fe absorption. This underpins the use of electric potential to retain micronutrients especially, cations around the root zone ultimately enhancing their availability for plants.
Evaluation and Characterization of Indigenous Rice (Oryza sativa L.) Landraces Resistant to Brown Planthopper Nilaparvata lugens (Stål.) Biotype 4
Authors: Roy Debashis , Biswas Abhisek , Sarkar Sukamal , Chakraborty Gautam 
Published: May 2022

Abstract
Evaluation and identification of resistant donors for brown planthopper (BPH) Nilaparvata lugens (Stål.), an economically important insect pest of rice, is a continuous process to develop new resistant rice varieties. However, several rice landraces of north-eastern India are not yet characterized for BPH resistance. In the present study, a set of 218 rice landraces were screened in both greenhouse and open-field conditions for three consecutive years, and thereafter forty selected promising entries were explored to evaluate their phenotypic and genotypic reactions against BPH biotype 4. Based on phenotypic evaluations, 5 landraces were identified as resistant, while 31 were moderately resistant, and grouped under the major cluster I and II, respectively, in a circular dendrogram. Antixenosis and antibiosis studies of these landraces divulged that, compared to the susceptible check variety, resistant landraces exhibited the lowest feeding rate, survival, and nymphal and adult settling, but higher frequency of unhatched eggs of BPH. Un-infested resistant landraces registered higher levels of ascorbic acid, oxalic acid and crude silica, however, elevated levels of total free amino acid, potassium and crude silica were observed under BPH herbivory. During the analysis of genetic diversity through 21 BPH resistance gene-linked SSR markers, the selected landraces were categorized into five major clusters at 10 unit distance by the scale of similarity. Most of the resistant landraces were grouped under the major cluster IV revealing their similar genetic history, whereas some were grouped with moderately resistant landraces displaying their genetic variation. The present study focuses on identifying new donors having BPH resistance resources which could be useful in genomic studies for the development of BPH biotype 4 resistant rice varieties.
Identification of Firm Multiplier of Comparable Firm Valuation Method on Indonesian IPO
Authors: Handaya Andrew , Warganegara Dezie L. , Warganegara Doni S. 
Published: May 2022

The aim of this research is to find the relevant valuation measurement, firm multiplier, which is utilized by issuers or underwriters during IPO. This research uses companies that conducted IPO, in the Indonesia Stock Exchange (IDX), within year 2001 to 2007, as the research sample. The hypotheses are developed to find the relevant valuation multiplier. The data are analyzed using One-Sample T Test, Kolmogorov-Smirnov (K-S) Test, and Binomial Test. The empirical results suggest that there are similarities and differences in valuation results when comparable firm valuation is utilizing different firm multiplier. Among the five methods, i.e. arithmetic mean, median, harmonic mean, closest ROA, and closest TA, the closest TA method performs the worst in Indonesia capital market during 2001-2007. There is no statistical difference between selecting arithmetic mean, median, and harmonic mean methods. The closest ROA method outperforms the arithmetic mean and closest TA methods; however it has similar performance to median and harmonic mean methods.
SPIRITUALITY ANALYSIS AND ORGANIZATIONAL COMMITMENTS IN MURABAHAH WITH INDIVIDUAL ACCURACY AS MEDIATION VARIABLE
Authors: Heykal Mohamad , Herawati Vinola 
Published: May 2022

The objective of this study is to analyze the spirituality of work and organizational commitment especially in murabahah financing. This study based on primary data and with explanatory format. This research environment for this study is real in the Islamic banking entitites in Jakarta. The sample of this research is financing staff in Islamic banking in Jakarta and the questioner was distributed to them. The result of this study is spirituality will influence the decision making process of murabaha financing in the Islamic financial entities in Jakarta with the mediation variable is individual accuracy mediates the relationship between murabaha financing approval processes and commitment to organizational goals.
Link of BIN1, CLU, and fIDE Gene Polymorphisms with the Susceptibility
of Alzheimer’s Disease: Evidence from a Meta-analysis
Authors: Abdul Aziz Md. , Md Ashraf Ghulam , Safiqul Islam Mohammad 
Published: May 2022

Background:
Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder.
The association of BIN1, CLU, and IDE genetic polymorphisms with AD risk have been evaluated
overtimes that produced conflicting outcomes.

Objective:
We performed this meta-analysis to investigate the contribution of BIN1 (rs744373 and
rs7561528), CLU (rs11136000 and rs9331888), and IDE (rs1887922) polymorphisms to AD risk.

Methods:
From a systemic literature search up to July 15, 2021, we included 25 studies with rs744373,
16 studies with rs7561528, 37 studies with rs11136000, 16 studies with rs9331888, and 4 studies with
rs1887922. To analyze the correlation, we constructed seven genetic models that used odds ratio and
95% confidence intervals. We used RevMan 5.4 for meta-analysis.

Results:
Our study suggests that BIN1 rs744373 is associated with a significantly increased risk of AD
in five genetic models (OR>1). Again, CLU rs11136000 showed reduced association in all genetic
models (OR<1). CLU rs9331888 revealed an increased association in two models (OR>1). The IDE
rs1887922 showed significantly increased risk in four models (OR>1). From subgroup analysis, a significantly
increased risk of AD was observed in Caucasians and Asians for BIN1 rs744373. Again,
BIN1 rs7561528 showed a significantly enhanced risk of AD only in Caucasians. CLU rs11136000
showed significantly reduced risk in Caucasians but rs9331888 showed increased risk in the same ethnicity.

Conclusion:
Our meta-analysis confirms the association of BIN1 rs744373, CLU rs9331888, and IDE
rs1887922 polymorphisms with an increased risk of AD, especially in Caucasians. Again, CLU
rs11136000 is associated with reduced AD risk in the overall population and Caucasians.
Therapeutic Potential of Naturally Occurring Lignans as Anticancer Agents
Authors: Shi Yumin , Wang Jun , Yan Heng 
Published: May 2022

:Cancer is a long-term and deadly pandemic that affects nearly a third of the world's population. Chemotherapy is currently the most common therapeutic treatment, but it is difficult to achieve satisfactory efficacy due to drug resistance and adverse effects.Natural products are becom-ing increasingly popular in cancer therapy due to their potent broad-spectrum anticancer potency and slight side effects. Lignans are complex diphenolic compounds comprising a family of second-ary metabolites existing widely in plants. Naturally occurring lignans have the potential to act on cancer cells by a range of mechanisms of action and could inhibit the colony formation, arrest the cell cycle in different phases, induce apoptosis, and suppress migration, providing privileged scaf-folds for the discovery of novel anticancer agents. In recent five years, a variety of naturally occur-ring lignans have been isolated and screened for their in vitro and/or in vivo anticancer efficacy, and some of them exhibited promising potential. This review has systematically summarized the re-sources, anticancer activity, and mechanisms of action of naturally occurring lignans, covering arti-cles published between January 2017 and January 2022.
Hospital Incidence and Medical Costs of Female Breast Cancer in Spain: A
Retrospective Multicenter Study
Authors: Darbà Josep , Marsà Alicia 
Published: May 2022

Background:
Breast cancer is the most prevalent cancer in women worldwide, causing the
greatest number of cancer-related deaths. This study aimed to evaluate the use of healthcare resources associated with female breast cancer in Spain, to analyze trends in hospitalization and death
rates, and the related direct medical costs

Methods:
A retrospective multicenter study analyzed records of hospital and ambulatory visits of
women diagnosed with breast cancer in Spanish hospitals between 1st January 2005 and 31st December 2018.

Results:
In total, 353,080 admission files were reviewed, mainly inpatient hospital admissions, corresponding to 299,585 individual patients. The median patient age was 59 years, 12.7% of admissions registered the presence of metastatic tumors, and 15.7% registered unspecified secondary tumors. The mean in-hospital death rate was 3.0% for patients without a metastatic disease and 10.5%
for patients with metastatic disease, decreasing significantly over the study period. The total age adjusted hospitalization rate increased between 2005 and 2011 and decreased after 2012. The mean
direct medical cost was €3824 per outpatient visit, €3995 per hospital admission up to 3 days and
€5001 per hospital admission over 3 days. Admission costs increased in patients with metastatic
disease and those deceased during hospitalization

Conclusion:
This study supports previous findings regarding the relative increase in breast cancer
incidence that could be attributed to the intensive screening and the reduction in the death rate. Mean
direct medical cost in this study varied greatly with the length of stay, presence of metastatic tumors
and disease fatality.
Mesenchymal Stem Cells: New Alternatives for Nervous System Disorders
Authors: Jiménez-Acosta Miguel Antonio , Hernández Lory Jhenifer Rochin , Cristerna Mayte Lizeth Padilla , Meraz-Ríos Marco Alejandro 
Published: May 2022

:
Mesenchymal stem cells (MSCs) are self-renewing cells found in almost all postnatal organs and tissues in the perivascular region. These cells have a high capacity for mesodermal differentiation; however, numerous studies have shown that MSCs can also differentiate into cells of endodermal and ectodermal lineages. Due to this multilineage differentiation capacity, these cells could function as restoratives of various cell populations after transplantation. However, not only their differentiation potential makes them ideal candidates for this, but also a series of trophic properties that promote regeneration in the surrounding tissue, such as their migratory capacity, secretory and immunomodulatory actions. This review analyzes several MSC transplantation trials to treat neurological diseases such as demyelinating injury, spinal cord injury, paraplegia, Parkinson's disease, cochlear injury, and Alzheimer's disease. These cells could facilitate functional recovery in multiple models of neurodegenerative diseases and nervous system injuries by using their trophic capacities, reducing inflammation in the injured area, reducing apoptosis, and enhancing endogenous neurogenesis through the secretion of bioactive factors. Furthermore, since cells derived from patients have demonstrated disease-associated differences in various brain diseases, these cells represent an excellent candidate for the study of these diseases, functioning as "a window to the brain."
Screening and in Silico Functional Analysis of MiRNAs Associated with
Acute Myeloid Leukemia Relapse
Authors: Fard Ali Amini , Rahimi Hamzeh , Shams Zinat , Ghoraeian Pegah 
Published: May 2022

Background:
Hematologic malignancies are among fatal diseases with different subtypes. Acute myeloid leukemia (AML) is a subtype that shows a high rate of invasion to different tissues.

Objective:
AML patients even after treatment show an increased rate of recurrence and this relapsed profile of AML has turned this malignancy into big challenges in the medical scope.

Methods:
In the current study, we aimed to investigate hub-genes and potential signaling pathways in AML recurrence. Two expression profiles of genes and non-coding RNAs were extracted from Gene Expression Omnibus (GEO) database. Target genes of identified miRNAs were predicted through bioinformatics tools. GO and KEGG pathway enrichment analyses were conducted to discover common target genes and differentially expressed genes. Protein‐protein interaction (PPI) network constructed and visualized through STRING online database and Cytoscape software respectively. Hub-genes of constructed PPI were found through the CytoHubba plugin of Cytoscape software.

Results:
As a result, 109 differentially expressed genes and 45 differentially expressed miRNAs were found, and the top enriched pathways were Immune response, Chemokine activity, Immune System, and Plasma membrane. The hub-genes were TNF, IL6, TLR4, VEGFA, PTPRC, TLR7, TLR1, CD44, CASP1, and CD68.

Conclusion:
The present investigation based on the in silico analysis and microarray GEO databases may provide a novel understanding regarding the mechanisms related to AML relapse.
Keywords: Acute myeloid leukemia, AML, Bioinformatics, microRNA, Protein‐protein interaction, Cancer.
Niveles de Confianza del Exceso de Mortalidad en los Estados Mexicanos en 2020
Authors: Fuentes Flores Noé Aarón , González König Gabriel , Brugués Rodríguez Alejandro , Ramirez Cervantes Alejandra 
Published: May 2022

La estimación oficial del exceso de mortalidad en esta emergencia del SARS-CoV-2 representa un progreso en la cuantificación de personas muertas por causa directa e indirecta del virus. Sin embargo, el hecho de que la estimaciones de estatales no sean válidas estadísticamente hace que sean directamente inútiles (o no confiables) para propósitos de política de salud y económica. Aquí, probamos la hipótesis nula de si la variación del estatal no es relevante durante la pandemia usando la distribución normal. Los resultados rechazan la hipótesis nula en 14 estados, se acepta en 8 estados y no se concluye en 6 estados.
Québec Questions: Québec Studies for the Twenty-First Century. Edited by Stéphan Gervais, Christopher Kirkey, and Jarrett Rudy. Oxford University Press, 2011.
Authors: Trépanier Anne 
Published: May 2022

Book Review: Québec Questions: Québec Studies for the Twenty-First Century. Edited by Stéphan Gervais, Christopher Kirkey, and Jarrett Rudy. Oxford University Press, 2011.
Anti Diabetic Activity of Methanolic and Chloroform Extracts of Solanum seaforthianum In Alloxan Induced Diabetes Rats
Authors: Gupta Atyam V S S S , Rama Rao Nadendla 
Published: May 2022

Diabetes mellitus is a syndrome characterized by elevated glucose levels, polyurea, polydipsia and weakness due to insufficient entry of available glucose into the cells of the body. There are many allopathic drugs available to manage diabetes such as Sulfonylureas, biguanides, gliptins etc., but associated with hypoglycemia, sweating, dizziness, confusion, hunger, weight gain on long term usage and tolerance will be developed which are further treated using multiple drugs. According to our ancient system of medicine there are many medicinal plants available to treat diabetes with the same potency of allopathic drugs. Natural products are considered to be an effective alternative for the treatment and management of diabetes, because of higher efficacy which initiated the present study of anti diabetic activity of Solanum seaforthianum in an alloxan induced diabetes male albino rat. Diabetes was successfully induced with the help of alloxan at a dose of 120 mg/kg body weight and the animals which are possessing the glucose levels more than 250 mg/dL included in the study. Diabetic induced rats were treated with methanolic and chloroform extracts (200 and 400 mg/kg/kg body weight) of Solanum seaforthianum for 10 days. The collected blood samples on 1st, 4th, 7th, and 10th day were used to determine serum biochemical parameters such as cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol, urea, creatinine and total protein. Results: The treatment with extracts of Solanum seaforthianum significantly reduced the elevated blood glucose levels and reversed other altered parameters of Cholesterol, Triglycerides, HDL, LDL, Urea, Creatinine and Total Protein. Among the two extracts of Solanum seaforthianum chloroform extract has shown comparatively significant (p<0.001) anti diabetic activity in alloxan induced diabetes in albino rats.
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Hough transform for lines with slope defined by a pair of co-primes
Authors: Chmielewski Leszek , Orłowski Arkadiusz 
Published: May 2022

Data structure and Hough-type algorithm suitable for finding the lines having the slope exactly specified by the ratio of small co-prime numbers is proposed. It is suitable for analysing images like the Ulam square in which the points representing prime numbers form such structures as contiguous lines and other regular sequences of points. This analysis is different from that in the case of images in which the real-world objects are represented approximately. Until now in the Ulam square the horizontal and vertical sequences, and those inclined by 45 deg were typically analysed. With the proposed method the sequences having slopes represented by such tangents like 1/3, 2/3, 3/4 etc. can be looked for.