bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving handwashing with Social Art for Behaviour Change: the experience of the Lazos de Agua programme in Latin America
Authors: Zisa Anna , Nilsson Kristina , Mirza Raisa , Vachon Tania 
Published: May 2022

Abstract
The effectiveness of different hygiene behaviour change approaches is inconsistent. Proven effective elements of behaviour promotion include the following: involving the community, adding psychosocial theory-derived elements and using interpersonal communication with active teaching methods and innovative and culturally sensitive messaging. The One Drop Foundation Social Art for Behaviour Change (SABC) approach encompasses those elements and is embedded in a system-strengthening approach involving users, service providers and policymakers within the Lazos de Agua Programme. Halfway into the programme, the SABC approach has been implemented in more than 280 rural and urban communities in five Latin American countries. According to its midline outcome measurement, the programme's efforts have contributed to a 15% point increase in the population practising proper handwashing within intervention areas. Story-based interviews revealed that SABC interventions are believed to have caused lasting changes in behaviour, perception and skills which transcend beyond the individual and are felt at the household and community levels. While the SABC approach is mostly limited to addressing psychosocial factors, the experience of this programme proves that artists can serve as behaviour change facilitators to accompany water, sanitation and hygiene (WASH) system projects. The SABC approach builds capacity, both within artist groups as permanent local institutions which can act as behaviour change facilitation service providers, and within service users, who become empowered and can continue influencing behaviour change among their peers.
The Potential Role of Plastome Copy Number as a Quality Biomarker for
Plant Products using Real-time Quantitative Polymerase Chain Reaction
Authors: Pandey Amita , Chaudhary Shifa , Bhat Binu 
Published: May 2022

Background:
Plastids are plant-specific semi-autonomous self-replicating organelles, containing
circular DNA molecules called plastomes. Plastids perform crucial functions, including photosynthesis,
stress perception and response, synthesis of metabolites, and storage. The plastome and
plastid numbers have been shown to be modulated by developmental stage and environmental stimuli
and have been used as a biomarker (identification of plant species) and biosensor (an indicator of abiotic
and biotic stresses). However, the determination of plastome sequence and plastid number is a laborious
process requiring sophisticated equipment.

Methods:
This study proposes using plastome copy number (PCN), which can be determined rapidly
by real-time quantitative polymerase chain reaction (RT-qPCR) as a plant product quality biomarker.
This study shows that the PCN log10 and range PCN log10 values calculated from RT-qPCR data,
which was obtained for two years from leaves and lint samples of cotton and seed samples of cotton,
rice, soybean, maize, and sesame can be used for assessing the quality of the samples.

Results:
Observation of lower range PCN log10 values for CS (0.31) and CR (0.58) indicated that the
PCN showed little variance from the mean PCN log10 values for CS (3.81) and CR (3.85), suggesting
that these samples might have encountered ambient environmental conditions during growth and/ or
post-harvest storage and processing. This conclusion was further supported by observation of higher
range PCN log10 values for RS (3.09) versus RP (0.05), where rice seeds in the RP group had protective
hull covering compared to broken hull-less seeds in the RS group. To further support that PCN is
affected by external factors, rice seeds treated with high temperatures and pathogens exhibited lower
PCN values when compared to untreated seeds. Furthermore, the range PCN log10 values were found
to be high for cotton leaf (CL) and lint (Clt) sample groups, 4.11 and 3.63, respectively, where leaf and
lint samples were of different sizes, indicating that leaf samples might be of different developmental
stage and lint samples might have been processed differently, supporting that the PCN is affected by
both internal and external factors, respectively. Moreover, PCN log10 values were found to be plant
specific, with oil containing seeds such as SeS (6.49) and MS (5.05) exhibiting high PCN log10 values
compared to non-oil seeds such as SS (1.96).

Conclusion:
In conclusion, it was observed that PCN log10 values calculated from RT-qPCR assays
were specific to plant species and the range of PCN log10 values can be directly correlated to the internal
and external factors and, therefore might be used as a potential biomarker for assessing the quality
of plant products.
Hypoxia-Inducible Factors-Based Single Nucleotide Polymorphism in Breast Cancer with More Cancer Susceptibility
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: May 2022

Abstract:
Hypoxia-inducible factors (HIFs) are a collection of transcriptional factors that
engage in the regulation of oxygen homeostasis. They are hypoxia-responsive stress
factors whose expression is linked to tumor growth and angiogenesis. HIF is a crucial
player in the progression of breast cancer. Patients with high levels of hypoxia-inducible
HIFs in their primary tumor biopsies had a higher chance of metastasis, the leading
cause of breast cancer-related death. HIF polymorphisms have been shown in several
epidemiological studies to influence breast cancer susceptibility. In the oxygendependent
degradation domain, several short nucleotide polymorphisms (SNPs) of the
HIF gene have been connected with higher HIF activity. To find SNP that make up the
genetic diversity that underpins the phenotypic difference found between individuals in
their susceptibility to cancer and the course of their disease, researchers used a variety
of potential pathway-based approaches.
Neoadjuvant Chemotherapy, Carboplatin, and Paclitaxel in Pregnancy of
a 22-Year Old with Stage IIA2 Cervical Cancer
Authors: Nurseta Tatit , Wardhana Anggia Prameswari , Nooryanto Mukhammad 
Published: May 2022

Background:
Cervical cancer is the second most common cancer found in pregnant women at a young age. Neoadjuvant with carboplatin and paclitaxel is often given to patients with cervical cancer, but the experience of administration during pregnancy is very limited.

Case:
A 22-year-old woman was diagnosed with stage IIA2 cervical cancer at 26 weeks gestation.
The patient received three medications, including neoadjuvant chemotherapy, carboplatin, and
paclitaxel, in three cycles with three weeks intervals at 27 weeks gestation. The patient underwent
pregnancy termination with emergency cesarean delivery at 36 weeks of gestation and continued
with a hysterectomy radical for 60 days, after which the patient received a chemoradiation adjuvant.
Mother and baby were found healthy at one year after the diagnosis.

Conclusion:
NACT inhibited progression of the disease and allowed fetal maturity in locally advanced cervical cancer patient at a young age, followed by radical hysterectomy 60 weeks after cesarean section. The combination of carboplatin and paclitaxel seemed feasible and relatively safe for
both the mother and the baby.
Renal Parenchymal Leiomyoma Mimicking Renal Cell Carcinoma: A
Case Report
Authors: Park Sung Bin , Song Minkyo , Lee Tae-Jin , Park Hyun Jeong , Lee Eun Sun , Kim Min Ju 
Published: May 2022

Background:
Renal leiomyoma is a challenging diagnostic and therapeutic condition. Given
that 90% of leiomyomas originate from the renal capsule, leiomyoma presenting as a renal parenchymal
mass is extraordinarily rare.

Case Presentation:
Herein, we report the clinical and imaging features of a patient with renal leiomyoma
occurring in the renal parenchyma and mimicking renal cell carcinoma. We also review the clinical,
imaging, and histological features of renal leiomyoma.

Conclusion:
An initial partial, simple or radical nephrectomy according to tumor size and patient’s
underlying condition is suitable for larger, heterogeneous, and non-peripherally located tumors, even if
they demonstrate hypointensity on T1- and T2-weighted images, considering the possibility of other
diagnoses.
A Case of Doxycycline-induced Melanin in the Gingiva Tissue: Case Report
Authors: Vieira Gustavo Henrique Apolinário , de Araújo Aurigena Antunes , de Freitas Rebeca Sá Leitão , de Souza Lélia Batista , Soares Ciro Dantas , de Carvalho Lilian Karine Cardoso Guimarães , Borges Samuel Batista , Gurgel Bruno Cesár de Vasconcelos , Dantas Euler Maciel , Rêgo Delane Maria 
Published: May 2022

Background:
Gingival pigmentation is a discoloration of the gingiva due to a variety of
lesions and conditions associated with several endogenous and exogenous etiologic features.

Objective:
The purpose of this study is to describe a report of gingival pigmentation in a patient
who used doxycycline.

Case Report:
A 21-year-old Caucasian female was under dermatological treatment and antibiotic
therapy with doxycycline 100 mg (one time a day) for 90 days. She presented brown pigmentation
at the gingival margin on the facial surfaces of the upper and lower anterior incisors and premolars.
The patient was evaluated by immunohistochemical (S-100, Melan-A, and HMB-45) and histopathologic
analyses, and clinical history. Blood levels of malondialdehyde (MDA), glutathione
(GSH), and superoxide dismutase (SOD) were analyzed by UV/Vis spectroscopy. The adrenaline,
noradrenaline, and dopamine in blood were analyzed by high-performance liquid chromatography
(HPLC); dehidroepiandrosterone (DHEA) in serum by radioimmunoassay; and luteinizing hormone
(LH) and 25-Hydroxyvitamin D by chemiluminescence. Hematoxylin-eosin stained sections
revealed keratinocytes with pigment compatible with melanin. The Fontana-Masson staining was
positive in melanophages and in some basal keratinocytes. S-100, Melan A and HMB-45 were confirmed
as positive markers of melanocytic differentiation in gingival tissue. We observed a significant
increase in malondialdehyde (p˂0.05) and a decrease in superoxide dismutase levels (p˂0.05).
The dopamine value was found to be 15 pg/ml (reference value ≤ 10 pg/ml).

Conclusion:
The use of doxycycline is associated with an increase in oxidative stress and of dopamine
with melanin pigments in the gingival tissue. This case report showed a cause-effect relationship
between exposure to doxycycline and pigmentation of the marginal gingiva.
Anorectal Function with High-Resolution Anorectal Manometry in Active
Ulcerative Colitis and after Remission: A Pilot Study
Authors: Gravina Antonietta G. , Federico Alessandro , Facchiano Angela , Scidà Giuseppe , Pellegrino Raffaele , Palladino Giovanna , Loguercio Carmelina , Docimo Ludovico , Romano Marco , Tolone Salvatore 
Published: May 2022

Background:
Ulcerative colitis may impair anorectal function, causing disabling symp-toms such as incontinence and/or increase in the stool frequency, urgency and tenesmus. Data on anorectal function in these patients evaluated by conventional anorectal manometry are conflicting.

Objectives:
The aim of this prospective study was to assess by means of high resolution anorectal manometry the anorectal function in patients with mild-to-moderate ulcerative colitis at presentation and after remission. Anorectal function of ulcerative colitis patients was compared to that observed in healthy volunteers.

Methods:
20 patients with mild to moderate left-sided ulcerative colitis or proctitis and 20 healthy volunteers were prospectively enrolled. All ulcerative colitis patients underwent high resolution ano-rectal manometry before treatment and after clinical remission.

Results:
Ulcerative colitis patients showed similar values for anal sphincter function as healthy vol-unteers, whereas rectal threshold volume for the first sensation, desire to defecate, urgency to defecate and maximum discomfort were significantly lower than in healthy volunteers (p<0.05). Rectal com-pliance was significantly lower in ulcerative colitis than in healthy volunteers (p<0.05). After remis-sion, rectal threshold volumes, as well as rectal compliance, significantly increased. An inverse linear correlation was found between regression of urgency and stool frequency and rectal compliance (r=0.811; p<0.05).

Conclusions:
Ulcerative colitis patients show altered rectal function, with increased rectal sensitivity and lower compliance, compared to controls. This altered function is restored after successful treat-ment of the underlying inflammatory process. Finally high resolution anorectal manometry provides useful information on anorectal functionality and, in our opinion, should be preferred over conven-tional manometry.
A Review Based on the Control Method of Thermal Error for High-Speed
Motorized Spindles
Authors: Qu Hang , Dai Ye , Wang Gang , Wen Wan-Jian , Xiang Chao-Fang 
Published: May 2022

Background:
The high-speed motorized spindle system is the main component and the
most significant heat source of high-precision CNC machine tools in mechanical processing. Plenty
of research shows that 60%~80% of the machining accuracy error comes from the thermal deformation
of each part in automated manufacturing. Therefore, it is urgent to study the control
method of thermal error for motorized spindle systems.

Objective:
Some valuable conclusions are drawn through the introduction and discussion of thermal
error control methods for motorized spindles in recent years, and we prospect the future research
and development of thermal error control methods for motorized spindles.

Methods:
The patents and papers based on the control methods of thermal error for motorized
spindles are studied. The advantages and disadvantages of thermal error control methods and their
research status are summarized.

Results:
With the urging of social as an essential part of CNC machine tools, we cannot ignore
the thermal error of high-speed motorized spindles. To improve the machining accuracy, increase
efficiency and prolong life, etc., all need a motorized spindle with excellent thermal dynamic performance.

Conclusion:
We analyze the structural characteristics and the primary heat sources of high-speed
motorized spindles, and review a mass of patents and papers related to the motorized spindle
thermal error control methods for investigation. By comparing these papers, some valuable conclusions
are drawn to predict the future research and development of thermal error control methods
for the motorized spindle.
Three Port Isolated AC/DC Converter with Power Factor Correction
Authors: Sharma Anurag , Gupta Rajesh 
Published: May 2022

1:
: This paper proposes a converter with three ports with isolated output and higher output power and voltage levels. The converter has two input ports, connecting an AC source and the solar PV source. The third port acts as an output port to supply the desired load. The proposed topology can supply the high dc output voltage with isolation while maintaining a high input power factor. A single-stage conversion is used, which helps in reducing the switching devices and the bulky electrolytic capacitor while integrating a Solar PV. As there is no intermediate stage of conversion in the proposed converter, thus it is well suited for the standalone PV based application such as remote light electric vehicle chargers. The simulation verification of the proposed converter is obtained in the MATLAB/SIMULINK and the experimental results are obtained using control algorithm implemented using FPGA based Typhoon HIL 402.

Background:
To implement the proposed novel converter and study the switching operations

Objective:
Conventionally, a two-stage conversion is required for providing isolated DC output

Methods:
Verification of control method in simulation with hardware validation

Results:
Justified the control method and working of topology

Conclusion:
The desired operation of the converter is achieved
Boosting High Added-Value Chemicals Formation By Means Of Photoelectrocatalysis
Authors: Bellardita Marianna , Palmisano Leonardo , Loddo Vittorio 
Published: May 2022

Abstract:
Within the current production systems, the need for low environmental impact processes to
produce chemicals, the treatment of aqueous effluents and the production of fuels is becoming an increasingly
urgent challenge. In this context, photoelectrocatalysis (PEC), which couples the electrochemical
method (EC) with photocatalysis (PC), can be considered a valid alternative to traditional
catalytic processes. It increases the photocatalytic and the electrochemical efficiency by improving the
separation of the photoproduced electrons and holes on the active electrode surface and addressing the
partial oxidation products formation by selecting the applied potential values. This review is concerned
with the possibility of forming PEC high-added-value chemicals, sometimes with the contemporary
production of hydrogen, by using different materials for the fabrication of photoanodes and
photocathodes in different solvents and system configuration, obtaining very interesting values of
conversion, selectivity, and Faradaic efficiencies. In particular, the review presents results related to
the production of valuable compounds by the valorisation of alcohols, biomass derivatives and some
peculiar organic substrates, highlighting the influence of electrode composition, applied bias, electrolyte
type, and solvent.
Burnout Syndrome in Emergency Physicians in Venezuela Early in the COVID-19 Pandemic
Authors: Medina-Ortiz Oscar , Oses Gil Alejandro , AlcendraGonzález Jenny , Diego Vivas Juan , Sánchez María Parra , Sánchez Luis Parra , Riaño-Garzón Manuel , Bautista-Sandoval María Judith , Herraez David Fraguas 
Published: May 2022

Background:
Burnout syndrome is a clinical entity that can negatively affect
healthcare workers, especially frontline medical staff.

Objective:
Determine the prevalence of burnout in emergency physicians at the start of the
COVID-19 pandemic.

Method:
The Maslach Burnout Inventory was administered to 150 emergency physicians
in 2020 during the first months of the pandemic in a Venezuelan hospital. There are two
limitations, the size of sample is small and the study physicians have poor social conditions
that do not allow generalizing the results.

Results:
Over three quarters of the physicians surveyed (76.7%) experienced burnout and
55.3% had health problems due to stress. The higher the number of years working in the
hospital and/or the lower the job satisfaction, the higher the burnout rate (p <0.05).

Conclusions:
A large number of physicians in Venezuela experienced burnout during the
first months of the pandemic, but half of them believed they did not need psychological
help. Prevalence of burnout was high among physicians with more years of service and
among those with lower job satisfaction.
Extracción de nutrientes del mango cv. Tommy Atkins en suelos Entisoles e Inceptisoles del departamento del Tolima, Colombia.
Authors: Yacomelo Hernández Marlon José , Abaunza González Carlos Alberto , Polanco Diaz Eliseo , Arenas-Rubio Isueh , Correa Álvarez Ender Manuel , Jaramillo Bonilla Sair 
Published: May 2022

El mango cv. Tommy Atkins es cultivado en el departamento del Tolima, principalmente, lugar donde expresa su mejor comportamiento agronómico y calidad de la fruta. El objetivo fue evaluar el estado nutricional de las plantas y cuantificar la extracción de nutrientes por la fruta de mango Tommy Atkins en función del orden de suelo donde se cultiva. Las concentraciones de cada nutriente variaron entre fases muestreadas y de órgano (hojas, flor y fruto) en función del orden del suelo donde es cultivado (Entisol e Inceptisol). La mayor extracción por cada mil kilogramos cosechado de fruta fue de Potasio (K) seguido de Nitrógeno (N) en los seis muestreos evaluados independientemente del orden de suelo (K, Entisol, E2=2,39 kg t-1, E3=2,07 kg t-1 y E4=2,00 kg t-1; Inceptisol E2=2,58 kg t-1, E3=2,40 kg t-1 y E4=2,05 kg t-1; N, Entisol, E2=1,56 kg t-1, E3=1,65 kg t-1, E4=1,46 kg t-1 e Inceptisol E2=1,52 kg t-1, E3=1,01 kg t-1 y E4=1,69 kg t-1). La extracción total de nutrientes por el mango cv. Tommy Atkins, por cada mil kilogramos cosechados fue cercana a 4,3 kg de nutrientes en suelos de orden Entisol y 4,5 kg de nutrientes en suelos de orden Inceptisol, siendo el orden de extracción K>N>P>Ca>Mg>S en suelos Entisol y K>N>Ca>P>Mg>S en suelos Inceptisol.
In Silico Comparative Analysis of the Functional, Structural, and Evolutionary Properties of SARS-CoV-2 Variant Spike Proteins
Authors: Math Renukaradhya K , Mudennavar Nayana , Javaregowda Palaksha Kanive , Savanur Ambuja 
Published: May 2022

BackgroundA recent global outbreak of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) created a pandemic and emerged as a potential threat to humanity. The analysis of virus genetic composition has revealed that the spike protein, one of the major structural proteins, facilitates the entry of the virus to host cells.ObjectiveThe spike protein has become the main target for prophylactics and therapeutics studies. Here, we compared the spike proteins of SARS-CoV-2 variants using bioinformatics tools.MethodsThe spike protein sequences of wild-type SARS-CoV-2 and its 6 variants—D614G, alpha (B.1.1.7), beta (B.1.351), delta (B.1.617.2), gamma (P.1), and omicron (B.1.1.529)—were retrieved from the NCBI database. The ClustalX program was used to sequence multiple alignment and perform mutational analysis. Several online bioinformatics tools were used to predict the physiological, immunological, and structural features of the spike proteins of SARS-CoV-2 variants. A phylogenetic tree was constructed using CLC software. Statistical analysis of the data was done using jamovi 2 software.ResultsMultiple sequence analysis revealed that the P681R mutation in the delta variant, which changed an amino acid from histidine (H) to arginine (R), made the protein more alkaline due to arginine’s high pKa value (12.5) compared to histidine’s (6.0). Physicochemical properties revealed the relatively higher isoelectric point (7.34) and aliphatic index (84.65) of the delta variant compared to other variants. Statistical analysis of the isoelectric point, antigenicity, and immunogenicity of all the variants revealed significant correlation, with P values ranging from <.007 to .04. The generation of a 2D gel map showed the separation of the delta spike protein from a grouping of the other variants. The phylogenetic tree of the spike proteins showed that the delta variant was close to and a mix of the Rousettus bat coronavirus and MERS-CoV.ConclusionsThe comparative analysis of SARS-CoV-2 variants revealed that the delta variant is more aliphatic in nature, which provides more stability to it and subsequently influences virus behavior.
„Ascending aortic thrombus associated with SARS-CoV-2”
Authors: Baczewski Kamil , Czajkowski Marek , Stążka Janusz 
Published: May 2022

Severe acute respiratory distress syndrome in association with
coronavirus 2 (SARS-CoV-2) occured more that 6 million cases in Poland
since first patient on 04, March 2020. We present patient with
SARS-CoV-2 and thrombus in ascending aorta. Clinically patient had also
significant coronary artery disease which schould be treated by cardiac
surgeons. Surgery was performer by medial sternotomy and systematic
hipothermia.