bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of risk factors and construction of a prediction model for short stature in children
Authors: Huang Shaojun , Chen Zhiqi , Chen Rongping , Zhang Zhen , Sun Jia , Chen Hong 
Published: December 2022

BackgroundShort stature in children is an important global health issue. This study aimed to analyze the risk factors associated with short stature and to construct a clinical prediction model and risk classification system for short stature.MethodsThis cross-sectional study included 12,504 children aged 6–14 years of age from 13 primary and secondary schools in Pingshan District, Shenzhen. A physical examination was performed to measure the height and weight of the children. Questionnaires were used to obtain information about children and their parents, including sex, age, family environment, social environment, maternal conditions during pregnancy, birth and feeding, and lifestyle. The age confounding variable was adjusted through a 1 : 1 propensity score matching (PSM) analysis and 1,076 children were selected for risk factor analysis.ResultsThe prevalence of short stature in children aged 6–14 years was 4.3% in the Pingshan District, Shenzhen. The multivariate logistic regression model showed that the influencing factors for short stature were father's height, mother's height, annual family income, father's level of education and parents’ concern for their children's height in the future (P &lt; 0.05). Based on the short stature multivariate logistic regression model, a short stature nomogram prediction model was constructed. The area under the ROC curve (AUC) was 0.748, indicating a good degree of discrimination of the nomogram. According to the calibration curve, the Hosmer–Lemesio test value was 0.917, and the model was considered to be accurate. Based on a risk classification system derived from the nomogram prediction model, the total score of the nomogram was 127.5, which is considered the cutoff point to divides all children into low-risk and high-risk groups.ConclusionThis study analyzed the risk factors for short stature in children and constructed a nomogram prediction model and a risk classification system based on these risk factors, as well as providing short stature screening and assessment individually.
Radioactive ion beam opportunities at the new FRAISE facility of INFN-LNS
Authors: Martorana N. S. , Cardella G. , Guazzoni C. , Pagano E. V. , Russo A. D. , Russotto P. , Acosta L. , Amato A. , Calabretta L. , Caruso A. , Cavallaro S. , Cosentino L. , Costa M. , De Filippo E. , De Luca G. , Geraci E. , Gnoffo B. , Maiolino C. , Passarello S. , Pirrone S. , Politi G. , Pulvirenti S. , Risitano F. , Rizzo F. , Santonocito D. , Trifiró A. , Trimarchi M. , Tudisco S. , Vecchio G. 
Published: December 2022

At the Laboratori Nazionali del Sud of INFN (INFN-LNS) in Catania, the construction of the new Radioactive Ion Beams (RIBs) facility FRAISE (FRAgment In-flight SEparator) has reached its ending phase. The facility uses the in-flight technique based on a primary beam fragmentation impinging on light Be or C targets. FRAISE makes use of light and medium mass primary beams, having power up to ≈ 2–3 kW, leading to RIBs, whose intensities vary in the range of ≈ 103–107 pps, for nuclei far from and close to the stability valley, respectively. FRAISE aims at providing high-intensity and high-quality RIBs for nuclear physics experiments, also serving to interdisciplinary research areas, such as medical physics. Critical aspects for high-quality beams are the tuning and transport, representing time-consuming processes and requiring dedicated diagnostics and tagging devices measuring many features of RIBs. Some of these devices should be capable to operate in radioactively activated environments because of the expected 2 kW beam lost in the dipole after the production target. Due to its peculiar robustness to radioactive damage, Silicon Carbide (SiC) technology has been considered for the detection layer. In this view, an R&amp;D campaign has been started aiming at developing the FRAISE facility, the new diagnostics system, and a new tagging device, the latter of which will be useful for the CHIMERA multidetector beamline. In this paper, we discuss the status and the perspectives of the facility with a focus on the RIBs opportunities.
Branched-chain amino acids promotes the repair of exercise-induced muscle damage via enhancing macrophage polarization
Authors: Dong Yunfeng , Zhang Xuejiao , Miao Rui , Cao Wei , Wei Hao , Jiang Wei , Gao Ruirui , Yang Yanhui , Sun Haipeng , Qiu Junqiang 
Published: December 2022

The repair of exercise-induced muscle damage (EIMD) is closely related with inflammation. Branched-chain amino acids (BCAAs), as a nutritional supplement, promote EIMD repair; however, the underlying mechanism remains unclear. In vivo, Sprague–Dawley rats were subjected to Armstrong’s eccentric exercise (a 120-min downhill run with a slope of −16° and a speed of 16 m min−1) to induce EIMD and BCAA supplement was administered by oral gavage. Protein expression of macrophages (CD68 and CD163) and myogenic regulatory factors (MYOD and MYOG) in gastrocnemius was analyzed. Inflammatory cytokines and creatine kinase (CK) levels in serum was also measured. In vitro, peritoneal macrophages from mice were incubated with lipopolysaccharide (LPS) or IL-4 with or without BCAAs in culture medium. For co-culture experiment, C2C12 cells were cultured with the conditioned medium from macrophages prestimulated with LPS or IL-4 in the presence or absence of BCAAs. The current study indicated BCAA supplementation enhanced the M1/M2 polarization of macrophages in skeletal muscle during EIMD repair, and BCAAs promoted M1 polarization through enhancing mTORC1-HIF1α-glycolysis pathway, and promoted M2 polarization independently of mTORC1. In addition, BCAA-promoted M1 macrophages further stimulated the proliferation of muscle satellite cells, whereas BCAA-promoted M2 macrophages stimulated their differentiation. Together, these results show macrophages mediate the BCAAs’ beneficial impacts on EIMD repair via stimulating the proliferation and differentiation of muscle satellite cells, shedding light on the critical role of inflammation in EIMD repair and the potential nutritional strategies to ameliorate muscle damage.
Study-related wellbeing, behavior, and attitudes of university students in the Netherlands during emergency remote teaching in the context of COVID-19: A longitudinal study
Authors: Vollmann Manja , Scheepers Renée A. , Nieboer Anna P. , Hilverda Femke 
Published: December 2022

IntroductionDuring the COVID-19 pandemic, emergency remote teaching was implemented at all conventional Dutch universities; however, the degree of limitations in on-campus teaching and learning varied during the pandemic dependent on the strictness of the measures. In the present study, it will be investigated how study-related experiences of university students changed in the face of varying limitations in on-campus teaching and learning.MethodsThe study had a longitudinal natural experiment design with three points of measurement during the academic year 2020–2021: November–December 2020 (t1; campuses partially open), March 2021 (t2; campuses fully closed) and June–July 2021 (t3; campuses partially open). In total, 680 Dutch university students (65.9% female; age: M = 21 years, SD = 2.06) filled in online surveys measuring study-related wellbeing (academic burnout and study-engagement), study-related behavior (study effort), and study-related attitudes (education satisfaction, online self-efficacy, and attitudes toward online education).ResultsOverall, students reported moderate levels of academic burnout, study engagement, study effort, education satisfaction, and online self-efficacy; their attitudes toward online education were rather negative. Students’ study-related wellbeing and education satisfaction decreased in the period when on-campus teaching and learning was impossible (t2) compared to periods in which on-campus teaching and learning was possible at a low level with several restrictions (t1 and t3). Students’ attitudes toward online education and online self-efficacy slightly increased at the end of the academic year (t3); however, the attitudes toward online education remained negative.DiscussionThe findings indicate that students’ academic burnout, study engagement, and education satisfaction varied over the course of the academic year in the context of changing limitations in on-campus teaching and learning. To facilitate positive study-related experiences, universities are advised to offer as much on-campus education as possible in times of pandemics.
Influence of play on positive psychological development in emerging adulthood: A serial mediation model
Authors: Ho Wing W. Y. 
Published: December 2022

IntroductionAlthough the literature reports that play provides substantial psychological benefits for individuals, it is often only emphasized by educators for younger children but less so for emerging adults. This cross-sectional study examined the impact of time spent engaged in play on emerging adults’ emotional intelligence, emotional traits, and resilience.MethodsParticipants (N = 131, 93.9% women) were full-time undergraduate students between the ages of 19 and 25 (M = 21.28,SD = 1.08).ResultsResults showed that play experiences cultivated emotional intelligence and strengthened resilience. Further, the findings supported a serial mediation model in which play was indirectly related to resilience through its effect on emotional intelligence and positive emotion.DiscussionPlay is recognized as a means to relieve stress and protect psychological wellbeing. Emerging adults who experience pleasure, enjoyment, learning, and the acquisition of new skills will benefit from play. Individuals should enhance positive play experiences, particularly sporting activities, to maintain a healthy work-life balance given the positive relationship between play, emotional intelligence, emotional traits, and resilience.
Hypertension and undiagnosed hypertension among Bangladeshi adults: Identifying prevalence and associated factors using a nationwide survey
Authors: Hossain Ahmed , Suhel Shakib Ahmed , Chowdhury Saifur Rahman , Islam Shofiqul , Akther Nayma , Dhor Nipa Rani , Hossain Mohammad Zakir , Hossain Mohammad Anwar , Rahman Syed Azizur 
Published: December 2022

BackgroundAlthough undiagnosed hypertension (HTN) is a serious concern worldwide, it is less of an importance in Bangladesh, where there is a dearth of research on the subject. So, we aimed to identify the prevalence and associated factors for diagnosed and undiagnosed HTN.MethodsWe analyzed the recent 2017–2018 Bangladesh Demographic and Health Survey data. We included 11,981 participants aged 18 years and above for the analysis. The prevalence rates of both diagnosed and undiagnosed hypertension were computed for all individuals and subgroups. The influence of socio-demographic, household, and community-related variables on HTN and undiagnosed HTN was investigated using multinomial regression analysis.ResultsThe study finds 1,464 (12.2%) of the 11,981 respondents [6,815 females [56.9 %]; mean age 39.4 years] had diagnosed HTN, whereas 1 898 (15.8%) had undiagnosed HTN. The HTN and undiagnosed HTN were significantly prevalent in the elderly, type 2 diabetic (T2DM), and overweight and obese individuals. In terms of residential regions, people from coastal region had a significantly higher prevalence of both HTN (RRR: 1.37; 95% CI: 1.17–1.62) and undiagnosed HTN (RRR: 1.35; 95% CI: 1.17–1.56) compared to those from the central region of Bangladesh.ConclusionsThe high prevalence of undetected hypertension in Bangladesh suggests that screening procedures for the current chronic illness may be inadequate in routine clinical practice. All populations should have access to hypertension screening, but it is especially crucial for the elderly, those with diabetes, those who are overweight or obese, and those from coastal and northern regions of Bangladesh.
Evaluation of a special needs dental workshop for health professionals and students in Trinidad and Tobago
Authors: Balkaran Ramaa , Perry Maureen , Maharaj Anushka , Rajhbeharrysingh Amrita , Virtanen Jorma I. 
Published: December 2022

AimsThis study aimed to evaluate a special needs dental workshop for dentists, allied dental health professionals and students in Trinidad and Tobago.MethodsThis feedback study conducted in 2019–2020, included two surveys, one at the time of the workshop and a second survey one year after it. The first survey utilized an anonymous self-administered questionnaire enquiring about the reason for attendance, profession/education, demographics, and difficulties faced in treating patients with special needs. The follow-up study used an online survey tool assessing the workshop and queried comments/suggestions. The Chi-square test served for statistical analysis.ResultsOf the 176 attendees 131 participated (response: 74.4%). The majority (81.5%) were females. Most attendees were dental students (50.3%) or dentists (38.9%). Knowledge acquisition (73.1%) and professional development (14.2%) were the main motives for attendance while communication (31.8%) and non-compliance (34.5%) were the main problems faced in treating patients with special needs. The follow-up evaluation (post-workshop) (response: 72.5%) showed that most participants (90.5%) assessed the workshop as positive; 80% reported an increase in their knowledge and 64.2% perceived a need for further education.ConclusionThese findings suggest a considerable demand for special needs dental services and continuing education and show that workshops can actively affect patient care.
"Rap é educação", rap e religião: propostas para o Ensino Religioso
Authors: Carvalho Rocha Bruno 
Published: December 2022

Misturando ritmo e poesia, o rap, gênero musical periférico, é constantemente atravessado por questões de classe, raça e gênero. Mas a religião, ainda que passe desapercebida por boa parte do público, constitui-se como fenômeno significativo da linguagem, expressão da identidade periférica, tão importante quanto outros temas e elementos mobilizados pelo rap. Assim, o objetivo deste artigo é relacionar o rap, a educação e a religião. O artigo estará dividido, portanto, em três partes: (a) um breve histórico do rap como objeto de pesquisa; (b) algumas estratégias de aproximação do rap e a religião; e por fim, (c) mostraremos o rap enquanto uma ferramenta pedagógica para novas abordagens no Ensino Religioso. Nossa hipótese é de que o rap, como fenômeno cultural, que abarca a religião como parte constitutiva da sua narrativa, potencialize processos de ensino-aprendizagem.
Associations of Air Pollution and Serum Biomarker Abnormalities in Individuals with Hemodialysis-Dependent Kidney Failure
Authors: Xi Yuzhi , Richardson David B. , Kshirsagar Abhijit V. , Flythe Jennifer E. , Whitsel Eric A. , Wade Timothy J. , Rappold Ana G. 
Published: December 2022

Key Points

Exposure to daily air pollution was associated with lower serum hemoglobin and albumin among patients receiving in-center hemodialysis.Inflammation could play a key role in the air pollution–related risk of mortality and cardiovascular disease among patients with hemodialysis.Patients with renal disease may be differentially vulnerable to health effects after air pollution exposure.

Background
Ambient particles with a median aerodynamic diameter of <2.5 µm (PM2.5) is a ubiquitous air pollutant with established adverse health consequences. While postulated to promote a systemic inflammatory response, limited studies have demonstrated changes in serum biomarkers related to PM2.5 exposure. We aim to examine associations between short-term PM2.5 exposure and commonly measured biomarkers known to be affected by inflammation among patients receiving maintenance in-center hemodialysis.

Methods
We conducted a retrospective open cohort study from January 1, 2008, to December 31, 2014. Adult hemodialysis patients were identified from the United States Renal Data System and linked at the patient level to laboratory data from a large dialysis organization. Daily ambient PM2.5 was estimated on a 1-km grid and assigned to cohort patients based on the ZIP codes of dialysis clinics. Serum albumin, serum ferritin, transferrin saturation (TSAT), and serum hemoglobin were ascertained from the dialysis provider organization database. Mixed-effect models were used to assess the changes in biomarker levels associated with PM2.5 exposure.

Results
The final cohort included 173,697 hemodialysis patients. Overall, the daily ZIP-level ambient PM2.5 averages were 8.4–8.5 µg/m3. A 10-µg/m3 increase in same-day ambient PM2.5 exposure was associated with higher relative risks of lower albumin (relative risk [RR], 1.01; 95% confidence interval [95% CI], 1.01 to 1.02) and lower hemoglobin (RR, 1.02; 95% CI, 1.01 to 1.03). Associations of same-day ambient PM2.5 exposure and higher ferritin and lower TSAT did not reach statistical significance.

Conclusions
Short-term PM2.5 exposure was associated with lower serum hemoglobin and albumin among patients receiving in-center hemodialysis. These findings lend support to the role of inflammation in PM2.5 exposure-outcome associations.
Esgotamento sanitário - estudo de caso: bairro Riacho Doce, município de Manaus
Authors: Silva Wendell Joniel Nascimento da , Geissler Rosa Mariette Oliveira , Pinheiro Érika Cristina Nogueira Marques 
Published: December 2022

Quatro em cada dez municípios do Brasil não tem serviço de esgoto. Na cidade de Manaus/AM, a população estimada pelo censo de 2021 é de 2.255.903 habitantes, e apenas 62.4% de domicílios tem o esgotamento sanitário adequado, desta maneira este artigo contribui para identificar o problema relacionado ao esgotamento sanitário do Bairro Riacho Doce e tentar melhorar melhorar qualidade de vida da população do bairro, além de poder contribuir propondo as possíveis soluções que são de extrema importância para conservar e proteger o meio ambiente. O presente artigo é apresentado na forma de estudo de caso, sobre os sistemas de esgotamento sanitário no bairro citado acima. O método de abordagem do artigo caracteriza-se como descritiva, através da revisão bibliográfica, de forma que a literatura científica traga uma análise mais técnica e específica, de natureza exploratória, realizado através da visita “in loco”. A pesquisa tem uma abordagem apresentada de forma quantitativa, visto que os resultados serão avaliados em função da quantificação da análise laboratorial. Desta maneira o objetivo geral deste artigo é descrever uma breve revisão bibliográfica sobre os tipos de esgotamento sanitário, através do estudo de caso realizado no local supracitado, evidenciado através de levantamento fotográficos, propondo as possíveis soluções de forma simples e prática. Para o estudo as soluções propostas foram, alternativas simples como instalação de sistemas compactos de fossa/sumidouro ou fossa/filtro/sumidouro, poderiam compensar desvios e inconformidades da gestão do tratamento de efluentes de forma descentralizada e a implantação de fossa séptica.
Cold-Adapted Yeasts from Patagonia Argentina
Authors: Garcia Virginia de , Broock Maria Rosa van 
Published: December 2022

The Patagonian Andes possess a great variety of glaciers, large temperate ice masses, and glacially formed water bodies. Most of these environments are included in protected areas characterized by low anthropogenic impact and minimal atmospheric pollution. Studies on occurrence of psychrotolerant (cold-adapted) and psychrophilic yeasts in these natural environments have allowed the characterization of native cold-adapted yeast communities, the description of six novel species, as well as description of the capability of these yeasts to produce extracellular enzymes, and other metabolites (carotenoids and mycosporines). Cold-adapted yeasts from Patagonian glaciers were able to hydrolyze natural polymers (casein, lipids, starch, pectin and carboxymethylcellulose) at low temperatures and some were able to produce photo-protective compounds. These results suggest a significant ecological role of these organisms as organic matter decomposers and nutrient cyclers, also reveal that some of these yeasts could be used for further metabolic, ecological and biotechnological studies. The objective of this review is to summarize all the findings related to cold adapted yeasts from glacial environments of the South Hemisphere (outside Antarctica), also to highlight the importance of continental ice masses from the microbiological perspective.
Keywords: yeasts, psychrophilic, glaciers, extracellular enzymes.
Network Structure Engineering for Dissemination Amplification in Social Networks using Reinforcement Learning
Authors: Ghasemi Abdorasoul , Karami Mohammad Ali 
Published: December 2022

<p>Network structure engineering aims to intervene in the network structure to improve a specific underlying process and has applications in many research fields like biology, transportation, and network design. Here we address the problem of online social networks (OSNs) engineering by link addition through the friend suggestion for an efficient dissemination process. We propose an end-to-end machine learning framework called <em>GCQL</em> for optimizing or generating an effective network structure to improve the dissemination process in OSNs. We first propose a dissemination model called <em>Complex-SII</em>, combining two widely used dissemination models in OSNs, SIR and IC, and complex contagion. The <em>GCQL</em> next uses a reinforcement learning algorithm called Neural Fitted <em>Q</em>-Iteration for optimizing a network structure for the dissemination process and uses a graph convolution network called <em>GCN</em> for graph embedding and learning the important patterns and characteristics of network structure for efficient spreading. The <em>GCQL</em> is trained with small-sized graphs and uses the learning outcomes for medium/large-sized graphs. Our simulation results show that <em>GCQL</em> can generate relatively more efficient network structures than the greedy approach for small-sized networks. <em>GCQL</em> also uses these results to develop relatively more efficient networks than the greedy approach for medium/large-sized network structures at a much higher speed. </p>
MODEL FLU EPIDEMI DENGAN DUA STRAIN VIRUS DAN VAKSINASI TUNGGAL
Authors: Noprisa Noprisa , Aryati L 
Published: December 2022

Pada paper ini, dibentuk model epidemi dengan vaksinasi hanya terhadap virus strain pertama. Analisis kestabilan pada model dilakukan dengan memperhatikan nilai parameter ambang batas . Model yang dibentuk menunjukkan adanya penyebaran strain virus kedua yaitu dampak dari pelaksanaan vaksinasi tunggal pada dinamika infeksi dua strain virus. Pada nilai parameter ambang batas tertentu, terdapat titik ekuilibrium bebas penyakit dan titik ekuilibrium endemik yang stabil asimtotik global. Simulasi numerik diberikan untuk mempermudah dalam interpretasi hasil analisisnya.