bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco‐anxiety in everyday life: facing the anxiety and fear of a degraded Earth in analytic work
Authors: Foster Stephen J. 
Published: November 2022

AbstractThis paper focuses on eco‐anxiety, an over‐arching term used to describe anxiety caused by the climate crisis and the impacts of environmental contamination, environmental disasters, species extinctions and ecological system degradation. A brief literature review of eco‐anxiety is provided from both psychoanalytic and Jungian perspectives which includes a discussion of Jung’s view of our split with nature, displacement anxiety, precarity, climate change denial, and anticipatory anxiety. The author draws on his own theory of what he calls the Nature archetype to explicate the psychological changes brought about by our environmental crisis that cause increased anxiety, depression, PTSD and which, sometimes, lead to suicide. Two clinical vignettes are provided. The first shows how eco‐complexes cluster around and interweave with generalized anxiety disorder, and the way in which eco‐anxiety can be incorporated into a fusional complex that draws the analyst into a fusional field experienced as a state of connection and disconnection over both personal and collective material. The second vignette illustrates the way in which eco‐complexes, eco‐anxiety and environmental issues are interwoven with an early childhood abuse history.
What factors help and hinder efforts to address incivility in Australasian emergency departments? A modified Delphi study of FACEM perspectives
Authors: Rixon Andrew , Skinner Clare , Wilson Samuel 
Published: November 2022

AbstractObjectiveWorkplace incivility is a global challenge for healthcare and a major leadership challenge facing emergency physicians. However, little is known about emergency physicians' understanding of the factors that help and hinder attempts to address incivility, or what emergency physicians believe are the priority factors to address. The present study makes a novel contribution to research in this area by examining the perceived enablers of, and barriers to, efforts to address incivility in Australian and Aotearoa New Zealand EDs.MethodsAn online modified Delphi study was conducted with 22 FACEMs. To structure the process, participants were sorted into four panels. Using a three‐phase Delphi process, participants were guided through the process of brainstorming, narrowing down and ranking the factors that help and hinder attempts to address incivility in EDs.ResultsThere was general agreement that FACEMs' cross‐department relationships and networks were key helping factors, and that poor workplace culture and time pressure were major hindering factors. However, despite agreement about these three factors, a wide range of intrapersonal, interpersonal, intergroup, and organisational factors were identified as pertinent to attempts to address incivility in EDs.ConclusionThe causes of incivility in Australian and Aotearoa New Zealand EDs are complex and highlight incivility in EDs as a key adaptive leadership challenge of emergency physicians. Fundamentally, the results underscore the need to foster a workplace culture of respect, inclusion and civility in Australasian hospitals.
Predictors of hospital readmission for patients diagnosed with delirium: An electronic health record data analysis
Authors: Friedrich Michaela‐Elena , Perera Gayan , Leutgeb Lisa , Haardt David , Frey Richard , Stewart Robert , Mueller Christoph 
Published: November 2022

AbstractIntroductionDelirium is an acute and fluctuating change in attention and cognition that increases the risk of functional decline, institutionalisation and death in hospitalised patients. After delirium, patients have a significantly higher risk of readmission to hospital. Our aim was to investigate factors associated with hospital readmission in people with delirium.MethodsWe carried out an observational retrospective cohort study using linked mental health care and hospitalisation records from South London. Logistic regression models were used to predict the odds of 30‐day readmission and Cox proportional hazard models to calculate readmission risks when not restricting follow‐up time.ResultsOf 2814 patients (mean age 78.9 years SD ±11.8) discharged from hospital after an episode of delirium, 823 (29.3%) were readmitted within 30 days. Depressed mood (odds ratio (OR) 1.34 (95% confidence interval (CI) 1.08–1.66)), moderate‐to‐severe physical health problems (OR 1.67 (95% CI 1.18–2.2.36)) and a history of serious circulatory disease (OR 1.29 (95% CI 1.07–1.55)) were associated with higher odds of hospital readmission, whereas a diagnosis of delirium superimposed on dementia (OR 0.67 (95% CI 0.53–0.84)) and problematic alcohol/substance (OR 0.54 (95% CI 0.33–0.89)) use were associated with lower odds. Cox proportionate hazard models showed similar results.ConclusionAlmost one‐third of patients with delirium were readmitted within a short period of time, a more detailed understanding of the underlying risk factors could help prevent readmissions. Our findings indicate that the aetiology (as alcohol‐related delirium), the recognition that delirium occurred in the context of dementia, as well as potentially modifiable factors, as depressed mood affect readmission risk, and should be assessed in clinical settings.
Effects of bioactive peptides derived from cottonseed meal solid‐state fermentation on the growth, metabolism, and immunity of yellow‐feathered broilers
Authors: Liu Jiancheng , Luo Yuanqin , Zhang Xiaoyang , Gao Yan , Zhang Wenju 
Published: November 2022

AbstractThis study investigated the effects of bioactive peptides derived from solid‐state fermentation of cottonseed meal on the growth performance, apparent dietary digestibility, serum biochemical parameters, protein metabolism, antioxidant activity, and immunity in yellow‐feathered broilers. A total of two hundred forty 21‐days‐old male broilers were randomly divided into four groups with six replicates per group. The control group received a basal diet and three experimental groups were fed diets with 1%, 2%, and 3% cottonseed meal bioactive peptides (CSBP) replacing equivalent protein of cottonseed meal in basic diet. Dietary supplementation of 2% and 3% CSBP increased the average daily weight gain, crude protein digestibility, total serum protein, and immunoglobulin (Ig) G contents in serum (P < 0.05). The 3% CSBP increased albumin, total antioxidant capacity, spleen weight/bodyweight, interleukin‐6, and IgM, while reducing the feed to gain ratio, total cholesterol, urea nitrogen, total superoxide dismutase, glutathione peroxidase, and malondialdehyde contents in serum (P < 0.05). The 2% CSBP diet increased PepT1 expression in duodenum, jejunum, and ileum (P < 0.05). The 1%, 2%, and 3% CSBP diets increased S6kinase‐polypeptide‐1 and inositol‐3‐hydroxylase expression in chest and leg muscles (P < 0.05). The CSBP addition in diets can improve growth performance, nutrient digestibility, protein metabolism, antioxidant, and immune capabilities of yellow‐feathered broilers.
Targeting CCL5 signaling attenuates neuroinflammation after seizure
Authors: Zhang Zhuoran , Li Yan , Jiang Shihe , Shi Fu‐Dong , Shi Kaibin , Jin Wei‐Na 
Published: November 2022

AbstractBackgroundEpilepsy is a neurological condition that causes unprovoked, recurrent seizures. Accumulating evidence from clinical and experimental studies indicates that neuroinflammation exacerbates seizure activity.MethodsWe investigated the transcriptional changes occurring in specific brain domains of a seizure mouse model, using 10× Genomics spatial transcriptomics. Differential gene expression and pathway analysis were applied to investigate potential signaling targets for seizure, including CCL5/CCR5 pathway. Maraviroc, an FDA‐approved C‐C chemokine receptor 5 (CCR5) antagonist, was used to verify the impact of CCL5/CCR5 signaling in seizure mice.ResultsWe found distinguished regional transcriptome features in the hippocampus of seizure mice. The hippocampus exhibited unique inflammatory gene signatures, including glia activation, apoptosis, and immune response in seizure mice. Especially, we observed notable expression of C‐C chemokine ligand 5 (CCL5) throughout the entire seizure hippocampus. Blockade of CCL5/CCR5 signaling via maraviroc prevented microglia activation and neuron degeneration in seizure mice.ConclusionsThis study supports the potential of CCL5/CCR5 signaling for targeting neuroinflammation after seizure.
Global prevalence of intellectual developmental disorder in dystrophinopathies: A systematic review and meta‐analysis
Authors: Pascual‐Morena Carlos , Cavero‐Redondo Iván , Álvarez‐Bueno Celia , Jiménez‐López Estela , Saz‐Lara Alicia , Martínez‐García Irene , Martínez‐Vizcaíno Vicente 
Published: November 2022

AbstractAimTo estimate the global prevalence of intellectual developmental disorder (IDD) and the IDD prevalence–genotype association in Becker muscular dystrophy (BMD) or Duchenne muscular dystrophy (DMD) according to the affected isoforms of the DMD gene: Dp427, Dp140, Dp71.MethodSystematic searches in MEDLINE, Scopus, Web of Science, and the Cochrane Library were conducted from inception of each database to March 2022. Observational studies that determined the prevalence of IDD in the population with BMD or DMD were included. Meta‐analyses of IDD prevalence and prevalence ratios of the IDD–genotype association were conducted.ResultsForty‐nine studies were included. The prevalence of IDD in BMD was 8.0% (95% confidence interval 5.0–11.0), and in DMD it was 22.0% (18.0–27.0). Meta‐analyses of IDD–genotype association showed a deleterious association between IDD and the number of isoforms affected in DMD, with a prevalence ratio = 0.43 (0.28–0.64) and 0.17 (0.09–0.34) for Dp140+/Dp71+ versus Dp140−/Dp71+ and Dp140+/Dp71+ versus Dp140−/Dp71− comparisons respectively. However, in BMD, there was no association for Dp140+/Dp71+ versus Dp140−/Dp71+.InterpretationThere is a high prevalence of IDD in BMD and DMD. Moreover, the number of isoforms affected is strongly and negatively associated with the prevalence of IDD in DMD.What this paper adds

The global prevalence of intellectual developmental disorder (IDD) was 8% in Becker muscular dystrophy and 22% in Duchenne muscular dystrophy (DMD).
The global prevalence of IDD in DMD was 12%, 29%, and 84% in participants with Dp427−/Dp140+/Dp71+, Dp427−/Dp140−/Dp71+, and Dp427−/Dp140−/Dp71− genotypes respectively.
In DMD, 12% and 22% of participants had abnormal performance IQ and verbal IQ values respectively.
‘It's just a natural human thing to do, to go and visit your family… but it's not easy for us’: Gender and generation in Bangladeshis’ transnational visits between London and Sylhet
Authors: Miah Md Farid , King Russell 
Published: November 2022

AbstractIn the title to this paper, Maya, a British‐Bangladeshi woman, expresses her frustration at the refusal of the Home Office to grant her father in Sylhet a visa to come and fulfil his role as family head at the wedding of his son, Maya's brother, in London. The case illustrates well the intersection of gender and generation that fundamentally shapes the pattern of visits, in both directions, across this long‐distance transnational social and family space. Bangladesh is a patriarchal society, with marked gender divisions layered across generations, which are largely reproduced among the migrant community in London and are manifested, in various ways, in the phenomenon of transnational visiting. Based on 61 in‐depth interviews in London and Sylhet, supplemented by participant observation, we delineate the gendered and generational structures framing the visits, both of migrants to the homeland and of non‐migrants to their relatives in London.
Anticipating prison face work: Dramaturgical risks anticipated by correctional officer recruits
Authors: Adorjan Michael , Ricciardelli Rosemary 
Published: November 2022

AbstractThere is increasing recognition that correctional officers (COs) serve a crucial role in their work in relation to communications underpinning discretion, especially regarding interactions with prisoners. This article examines attitudes and perceptions among Canadian federal correctional officer recruits (CORs) regarding what they anticipate are the greatest challenges they will face as new COs. We examine these discussions through the framework of Goffman's dramaturgical model of face work, especially face work within the ‘total institution’ of prisons. Our findings centre on anticipated challenges of building rapport with prisoners, including the requirements to monitor one's demeanour and ‘face work’. Characterisations of prisoners as inherently manipulative factor into CO anticipations of interactional challenges. We also consider the role that ‘soft power’ has in facilitating CO‐prisoner rapport and trust, which, we argue, ultimately undergirds opportunities in prisons to facilitate prisoner social change and successful community reintegration and desistance from crime.
Biomarker diversity in increased inflammation: Secondary hemophagocytic syndrome vs. systemic inflammatory response syndrome
Authors: Bozgul Sukriye Miray Kilincer , Ak Gunes , Soyer Nur Akad , Barutcuoglu Burcu , Mercan Erman , Acar Caner , Yetişken Merve , Hekimgil Mine , Bozkurt Devrim 
Published: November 2022

AbstractIntroductionSecondary hemophagocytic syndrome (HPS) and systemic inflammatory response syndrome (SIRS) share similar clinical findings as a result of hyperinflammation. Due to high mortality rates in HPS; it is critical to diagnose promptly. Thus, this study aimed to evaluate the diagnostic and prognostic significance of inflammatory markers in these two increased inflammatory states.MethodsWe conducted a prospective observational study including patients hospitalized in the intensive care unit of the Internal Medicine Department of Ege University Hospital.ResultsThirty‐three patients with HPS and 46 patients with SIRS were evaluated. Serum ferritin and sIL‐2r levels were significantly higher in the HPS group than in the SIRS group, as expected. Receiver operating curve (ROC) analysis showed that the optimal cutoff for ferritin to distinguish HPS from SIRS was 1703 μg/L (sensitivity: 75%, specificity: 94.1%, area under the curve (AUC): 0.871, p < 0.001), and that for sIL‐2r was 5888 U/ml (sensitivity: 45.5%, specificity: 89.1%, AUC: 0.698, and p = 0.001). Temporal changes (Δ) in ferritin were determined as a mortality predictor. When evaluated in terms of prognostic significance in ROC analysis, a decrease in ferritin of less than 38% was the cutoff value (sensitivity: 92.3%, specificity: 76.9%, AUC: 0.888, and p < 0.001), in mortality. Contrarily, neither baseline nor temporal change in sIL‐2r did not achieve prognostic significance as a mortality predictor.ConclusionIn this single‐center study, serum ferritin level was found to be a particularly more valuable diagnostic and prognostic marker than sIL‐2r in patients with HPS.
Treatment of patients with Waldenström macroglobulinaemia: clinical practice update from the Myeloma Foundation of Australia Medical and Scientific Advisory Group
Authors: Talaulikar Dipti , Joshua Douglas , Ho Phoebe Joy , Gibson John , Quach Hang , Gibbs Simon , Ling Silvia , Ward Christopher , Augustson Bradley M. , Trotman Judith , Harrison Simon J. , Tam Constantine S. ,   the Medical and Scientific Advisory Group, Myeloma Australia
Published: November 2022

AbstractWaldenström macroglobulinaemia (WM) is an indolent B‐cell malignancy characterised by the presence of IgM paraprotein, bone marrow infiltration by clonal small B lymphocytes with plasmacytic differentiation and the MYD88 L265P mutation in >90% of cases. Traditionally, WM has been treated with chemoimmunotherapy. Recent trials have demonstrated the efficacy and safety of Bruton tyrosine kinase inhibitors in WM, both as monotherapy and in combination with other drugs. There is emerging evidence on the use of other agents including B‐cell lymphoma 2 inhibitors and on the treatment of rare presentations of WM. In this update, the Medical and Scientific Advisory Group of Myeloma Australia reviews the available evidence on the treatment of WM since the last publication in 2017 and provides specific recommendations to assist Australian clinicians in the management of this disease.
Bone marrow transplantation for acute leukaemia in childhood
Authors: Vowels M. R. , Lam‐Po‐Tang R. , Heller E. , Mameghan H. , Oliver L. , Alexander I. , Ziegler J. , Hughes D. O'Gorman 
Published: November 2022

This report describes the first successful bone marrow transplantation on a child with acute ieukaemia in Australia. A nine‐year‐old boy while in his fifth bone marrow remission received a bone marrow transpiant from his brother following “supralethal” treatment with cyclophosphamide (60mg/kg on two successive days) and totai body irradiation to a dose of 840‐1040 rads. (8.4‐10.4Gy). The subsequent course was complicated by fever for 11 days and a ciinicaliy miid cytomegalovirus infection. Bone marrow reconstitution occurred from day 11 post transplant. Currently, 39 months later the child remains well, with a normal functioning bone marrow of donor origin, is free of leukaemia and is off all treatment.Review of the literature indicates that bone marrow transplantation is a potentially valuable form of treatment for acute leukaemia in children once bone marrow relapse has occurred and when an histocompatible sibling is available. Survival following transplantation is significantly better if transplantation is performed during bone marrow remission as opposed to relapse. In such circumstances it offers a better potential for long term survival compared to conventional drug therapy.
Application of T‐cell receptor repertoire as a novel monitor in dynamic tracking and assessment: A cohort‐study based on RA patients
Authors: Yang Peiqing , He Yijing , Qing Pingying , Xu Wangdong , Xie Dan , Cazier Jean‐Baptiste , Liu Xiao , Varnai Csilla , Zhou Yi , Zhao Yi , Tang Huairong , Yin Xiaoming , Liu Yi 
Published: November 2022

AbstractT‐cell receptor repertoire (TCRR) sequencing has been widely applied in many fields as a novel tool. This study explored characteristics of TCRR in detail with a cohort of 598 rheumatoid arthritis (RA) patients before and after anti‐rheumatic treatments. We highlighted the abnormal TCRR distribution in RA characterized by decreased diversity and increased proportion of hyperexpanded clones (HECs), which was potentially attributed to skewed usage of global V/J segments but not a few certain ones. Enriched motifs analysis in RA community demonstrated the huge heterogeneity of CDR3 sequences, so that individual factors are strongly recommended to be taken into consideration when it comes to clinical application of TCRR. Disease‐modifying antirheumatic drugs (DMARDs) can regulate immune system through recovery of TCRR richness to relieve symptoms. Remarkably, sensitive gene profile and advantageous gene profile were identified in this study as new biomarkers for different DMARDs regimens.
How Foundational Narratives Shape European Union Politics
Authors: De Vries Catherine E. 
Published: November 2022

AbstractIn this article, I distinguish between four foundational narratives about the EU and outline how they continue to shape EU politics of the present day. The foundational narratives are (1) the EU as a peace project, (2) the notion that the EU is forged in crisis, (3) the sense that deeper economic interdependence fosters political change and (4) the idea that law can replace power politics in the EU. In order for the European project to address current challenges, such as climate change, economic instability, political polarization or the rule of law crisis, I argue that Europeans need to confront their past. History is not only the recollection of events; it represents the connections that the public and elites wish to make. So, in order to develop policy solutions to cross‐border issues, European contemporaries need to critically revisit past connections and to uncover blind spots. If Europeans revisit the EU's foundational narratives, they might also figure out what should change in the EU today.
Pathological neutrophil migration predicts adverse outcomes in hospitalized patients with liver cirrhosis
Authors: Langer Mona‐May , Sichelschmidt Stefanie , Bauschen Alina , Bornemann Lea , Guckenbiehl Sabrina , Gunzer Matthias , Lange Christian M. 
Published: November 2022

AbstractBackground and AimsGiven the early response of neutrophil granulocytes to infections, detection of pathological neutrophil migration might help in predicting adverse events in patients with liver cirrhosis.MethodsMigration of blood neutrophils in hospitalized patients with cirrhosis was characterized by a novel standardized migration assay. Pathological neutrophil migration patterns were associated with a composite endpoint of ACLF, sepsis or death within 7 or 30 days.ResultsOverall, 125 patients were included, of whom 11 (8.8%) had compensated cirrhosis, 84 (67.2%) had acute decompensation (AD) and 30 (24%) had acute‐on‐chronic liver failure (ACLF). The migration response of neutrophils from patients with AD or ACLF to stimulation with the chemotactic formylpeptide f‐Met‐Leu‐Phe (fMLP) was significantly impaired, while the response to chemokine (C‐X‐C motif)‐ligand 8 (CXCL8) was affected less pronouncedly. In contrast, no relevant differences in response to CXCL1 were observed. Of note, neutrophils of a number of patients with AD and ACLF were largely immotile at resting and stimulated conditions. Patients with non‐migrating neutrophils at unstimulated conditions were at high risk to develop the composite endpoint of ACLF, sepsis or death. Moreover, expression of chemokine receptors CXCR1 and CXCR2 was significantly decreased in patients with ACLF. Interestingly, the expression of chemokine receptors did not correlate with neutrophil migration patterns, but—based on the increased expression of the cell surface markers CD66b and CD177—neutrophils of patients with AD and ACLF were strongly pre‐activated.ConclusionPathological neutrophil migration in patients with cirrhosis indicates a high risk of developing adverse outcomes.