bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contact allergy to and allergic contact dermatitis from formaldehyde and formaldehyde releasers: A clinical review and update
Authors: Goossens An , Aerts Olivier 
Published: March 2022

AbstractThis review aims to provide a clinically useful update regarding the role of formaldehyde (FA) and its five main releasers (FRs) quaternium‐15, diazolidinyl urea, DMDM hydantoin, imidazolidinyl urea, and 2‐bromo‐2‐nitropropane‐1,3‐diol (bronopol) in contact allergy and allergic contact dermatitis. These ubiquitous preservatives are still often present, and sometimes undeclared, in cosmetics, pharmaceuticals, medical devices, household detergents, and chemical (industrial) products. In Europe, the use of free FA and quaternium‐15 in cosmetics is forbidden and contact allergy rates have been found to be stable to decreasing. However, FA/FRs still readily provoke localized (eg, facial/hand), airborne, and generalized dermatitis, and may also complicate atopic and stasis dermatitis, or result in nummular dermatitis. Seborrheic‐, rosacea‐ and impetigo‐like dermatitis have recently been reported. For a correct diagnosis, FA 2% aq. (0.60 mg/cm2) should be used, and particularly the FRs bronopol 0.5% pet. and diazolidinyl urea 2% pet. should be patch tested separately in a baseline series. If sensitization to FA occurs, both FA and FRs should preferably be avoided, except perhaps for bronopol in case it tests negatively. If a patient reacts to one or more FRs (such as bronopol or diazolidinyl/imidazolidinyl urea), but not to FA, then the specific FR(s) should be avoided.
Polylysine dendrigraft is able to differentially impact Cutibacterium acnes strains preventing acneic skin
Authors: Attia‐Vigneau Joan , Barreau Magalie , Le Toquin Esther , Feuilloley Marc G.J. , Loing Estelle , Lesouhaitier Olivier 
Published: March 2022

AbstractWith a view to reducing the impact of Cutibacterium acnes (C. acnes) on acne vulgaris, it now appears interesting to modify the balance between acneic and non‐acneic strains of C. acnes using moderate approach. In the present study, we identified that a G2 dendrigraft of lysine dendrimer (G2 dendrimer) was able to modify membrane fluidity and biofilm formation of a C. acnes acneic strain (RT5), whereas it appeared no or less active on a C. acnes non‐acneic strain (RT6). Moreover, skin ex vivo data indicated that the G2 is able to decrease inflammation (IL1α and TLR‐2) and improve skin desquamation after of C. acnes acneic strains colonization. Then, in vivo data confirmed, after C. acnes quantification by metagenomic analysis that the G2 cream after 28 days of treatment was able to increase the diversity of C. acnes strains versus placebo cream. The data also showed a modification of the balance expression between C. acnes phylotype IA1 and phylotype II abundances. Taken together, the results confirm the interest of using soft compounds in cosmetic product for modifying phylotype abundances and diversity of C. acnes strains could be a new strategy for prevent acne vulgaris outbreak.
Bias‐driven marketing that instigates pledging to a crowdfunding campaign: An experimental consideration of behavioral anomalies
Authors: Panneerselvam Theerthaana , Joe Arun C. 
Published: March 2022

AbstractBias‐driven marketing leverages the behavioral biases of investors for greater marketing gains. To transform cognitively biased individuals from antagonists into allies, the marketers need to decipher the critical crowdfunding attributes, which ultimately motivate behaviorally biased crowdfunders to invest in crowdfunding campaigns. Hence, this study seeks to investigate the influential factors concerning four behavioral biases that accelerate crowdfunding adoption. A conceptual model, parameterized using conjoint analysis, is developed and administered in an agent‐based behavior model to effectively determine the influential crowdfunding attributes, which will induce the biased investors to adopt crowdfunding. The results revealed that status quo biased individuals adopted the crowdfunding campaign when launched by well‐known and reputed fund raisers. Whereas, hyperbolic discounting bias accelerated the adoption when the campaign reached more than 75% of subscription and duration was lesser than 30 days. The results also indicated that framing bias enhanced the adoption when the risk inherent in the project is disclosed. Finally, the results also claimed that individuals liable to loss aversion bias expected a known funder, who posts frequent updates and preferred the All‐or‐Nothing crowdfunding model. The experimental results of the study provide insights to the marketers that crowdfunding campaigns can be successfully strategized through the exploration of underlying cognitive biases and the corresponding motivational cues that accentuate the pledging behavior of the funders. Given the importance of an effective marketing strategy in crowdfunding adoption, this study offers one such recommendation to the crowdfunding campaigners by demonstrating how bias driven marketing strategy enhances the adoption rate of the campaigns. With the strong pieces of evidence obtained from this study, it is anticipated that behavioral biases, drawn from the neuromarketing theory, will no longer be viewed as cognitive errors from the investor's perspective. Rather, it will be viewed as a boon from the marketer's perspective as the bias‐based marketing strategies have the potential to achieve a fully subscribed crowdfunding campaign.
Alternative protein consumption: A systematic review and future research directions
Authors: Nguyen July , Ferraro Carla , Sands Sean , Luxton Sandra 
Published: March 2022

AbstractMarketing plays a critical role in addressing macro‐level societal problems, one of which relates to the reduction of meat consumption and increased consumption of alternative proteins. Such consumption practices are gaining attention given the rising concerns about food sustainability, safety, security, nutrition, and animal welfare. This paper provides a framework‐based systematic review of alternative protein consumption research, identifying relevant articles published between 2000 and 2020. Our framework combines the socio‐ecological model and capability, opportunity, and motivation model of behavior (COM‐B) to identify the various factors influencing alternative protein consumption. Antecedents – facilitators and barriers – of alternative protein consumption are organized, synthesized, and discussed using this combined model of behavioral influence. Our review outlines methodological approaches, identifies main variables of interest, highlights the opportunity for further theoretical development, and identifies gaps in research related to individual‐level opportunities and system‐level motivations. We conclude with theoretical, contextual, and methodological directions for marketing and consumer research to better understand and shape decisions and practices regarding the consumption of alternative proteins.
Plate Objective Scoring Tool: A new preoperative indicator of penile curvature degree in children with distal hypospadias
Authors: Abbas Tariq O , Hatem Mohamed , Chandra Prem 
Published: March 2022

ObjectivesThere is an unmet need for preoperative methods that surgeons can use to objectively quantify hypospadias anatomic variables and determine risk of penile curvature. We, therefore, assessed whether Plate Objective Scoring Tool measurements were correlated with degree of ventral curvature in affected children.MethodsPatients undergoing distal hypospadias repair were enrolled into the study between January 2018 and December 2020 and were categorized independently by at least two surgeons using Plate Objective Scoring Tool. Scores were compared statistically to determine the degree of ventral curvature and requirement for correction.ResultsSixty‐five patients with a median age of 18 months (interquartile range 13–26) were enrolled into the study prior to surgery for primary distal hypospadias. Patient probability of significant postoperative curvature (>20°) was determined with moderate confidence using a cutoff Plate Objective Scoring Tool score of 1 (sensitivity 75%, specificity 60%). Presurgery Plate Objective Scoring Tool scores were negatively correlated with subsequent degree of curvature (r = −0.37, P = 0.003), with values <1.0 predicting >20° curvature.ConclusionsPlate Objective Scoring Tool scoring offers a succinct method of describing hypospadias severity and correlates well with postoperative outcomes. The Plate Objective Scoring Tool system can therefore be used to objectively predict the likelihood of penile curvature and aid communication between surgeons and researchers, as well as improving parental counseling.
Reconsidering the nexus between monetary policy and economic growth in Nigeria: The role of interest rate, money supply, and financial inclusion
Authors: Iorember Paul Terhemba , Jelilov Gylych , Alymkulova Nargiza , Yua Paul Mkuma 
Published: March 2022

AbstractThe empirical evidence on the nexus between monetary policy and economic growth remains ambiguous with mixed and differing results, depending on the country's characteristics, the choice of monetary policy variables employed, and recently, the place of financial inclusion in monetary policy formulation and transmission mechanism. This study explores the nexus between monetary policy and economic growth in Nigeria while accounting for the roles of interest rate, money supply, and financial inclusion over a base period of 2004q1 to 2020q4 and a projected period of 30 quarters. Using the dynamic simulation autoregressive distributed lag (ARDL) model, the study finds that in the short run, only the effect of money supply on economic growth is statistically significant. However, in the long run, interest rate, money supply, and financial inclusion have statistically significant effects on economic growth. The results are supported by the plots of the dynamic simulated ARDL, where economic growth response is predicted at various time periods after forcing a ±1% change (positive and negative shocks) in interest rate, money supply, and financial inclusion. We, therefore, recommend among other things an aggressive financial inclusion strategy with clearly defined deliverables and timelines to reduce the percentage of persons excluded from the formal financial system.
Playing is just the beginning: Social learning dynamics in game communities of inquiry
Authors: Gandolfi Enrico 
Published: March 2022

AbstractBackgroundOnline game communities are inhabited by millions of players daily with relevant learning opportunities and dynamics. However, little efforts have been done for exploring their potential.ObjectivesThe goal of this study is to explore if and how social learning processes are occurring in online game communities.Methodsn = 480 adult players completed a questionnaire including demographics, game community habits, and the game community of inquiry scale. Results were analysed by referring to social learning theory's processes and factors.Results and ConclusionsOnline game communities provide relevant instances of social learning, with an emphasis on soft skills and application to off‐game contexts. Moreover, the more a community is inclusive and supporting, the more individuals learn and benefit from it from a cognitive perspective.Major takeawaysThis study provides a wide overview of the processes through which players observe, filter, and reproduce behaviours from their game communities of reference. Moreover, findings point at which malleable factors should be considered for facilitate this social learning dynamic, which are active participation, community receptiveness, and being aware of the learning process itself.
The optimal duration of capecitabine plus temozolomide in patients with well‐differentiated pancreatic NETs with or without maintenance therapy
Authors: Gao Heli , Dong Jia , Zhang Wuhu , Xu Huaxiang , Ye Longyun , Li Hao , Wang Wenquan , Liu Liang , Yu Xianjun 
Published: March 2022

AbstractBackgroundThe optimal duration of capecitabine combined with temozolomide (CapTem) for metastatic pancreatic neuroendocrine tumours (PanNETs) remains controversial. The present study aimed to assess the activity and safety of prolonged CapTem and Cap maintenance therapy in patients with metastatic PanNETs.MethodsRetrospective real‐world data of 94 patients with metastatic PanNETs were obtained from one cancer centre. Fifteen patients were treated with Cap maintenance therapy after fixed 12–13 cycles of CapTem (group I), 44 patients were treated with prolonged CapTem until disease progression (group II), and 35 patients were treated with fixed 12–13 cycles of CapTem (group III).ResultsThe mean ± SE follow‐up period was 41.79 ± 26.31 months. The median CapTem treatment duration was 12 months in group I and 14 months in group II. The median time to best partial response was 12 months both in groups I and group II. The objective response rates of groups I and II were significantly higher than those of group III (73.3%, 41.9%, and 20%, respectively, p = .002). The median progression‐free survival (mPFS) of group I and group II was significantly higher than that of group III (35 months, 26 months vs. 19 months, p < .001). Safety analysis of the three groups indicated rare events of grade 3–4 toxicities, with nausea, vomiting, fatigue, and anaemia being the most common adverse effects.ConclusionsPatients with PanNETs who responded well to CapTem treatment may benefit from prolonged CapTem and Cap maintenance therapy after fixed cycles. Prospective studies are encouraged to further explore the prolonged CapTem treatment and maintenance therapy.
Pandemics and consumer well‐being: Provenance and research priorities
Authors: Pradhan Debasis 
Published: March 2022

AbstractThis article advances the riveting discussion on how this special issue contributes to the consumer well‐being literature. Specifically, this article endeavors to present an eclectic account of how the pandemics has had a lasting impact on the consumer well‐being, its provenance and future research priorities for academics and practice. First, it briefly discusses the origin and relevance of the evolving issue of consumer well‐being during pandemics. Second, it presents several directions for future research and third, it offers key insights for policymakers. It includes multiple research priorities that present vastly contrasting manifestations of consumer well‐being. This article argues that future research will need to examine the drivers of consumer well‐being during pandemics, the mechanisms that underlie the influence of pandemics on consumer well‐being and the boundary conditions that accentuate/mitigate the influence of pandemic‐induced factors.
Why Do Some Multinational Firms Respond Better Than Others to the Hostility of Host Governments? Proximal Embedding and the Side Effects of Local Partnerships
Authors: Moschieri Caterina , Ravasi Davide , Huy Quy 
Published: March 2022

AbstractUsing a multiple‐case study of alleged expropriations reported before the World Bank, we examine how multinational companies (MNC) react to the escalating hostility of host governments. Our study reveals how different choices regarding the interaction with local nonmarket stakeholders – which we refer to as proximal vs. mediated embedding – shape how managers respond to these disputes by affecting their ability to collect, process and interpret information, and to act upon it in a way that effectively mobilizes local and international support. In contrast to the prevailing view that local partners in international joint ventures shelter MNCs from abuse from political authorities, our findings show that primary reliance on local partners to manage the local nonmarket environment can actually reinforce a liability of outsidership and even create a ‘liability of insidership’, to the extent that relying on local partners prevents the MNC from establishing quality connections with a broad range of nonmarket stakeholders, reducing its alertness and responsiveness to hostile acts from host governments.
What drives trust of the long‐term unemployed in their caseworkers?*
Authors: Wilde Joachim 
Published: March 2022

AbstractResearch about drivers of trust of the long‐term unemployed in their caseworkers is a white spot in the literature. The paper closes this gap using a unique data set. Embedded in a theoretical model at the organizational level a trust game with real long‐term unemployed and caseworkers is evaluated. The results support the social identity theory, i.e. trust in members of the ‘own’ group is higher than trust in members of the ‘other’ group, as well as more traditional explanations of trust. Thus, policy can raise trust using the concept of incentive ethics of the theoretical model.
Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to HSV1 primary infection
Authors: Spahn Stephan , Riessen Reimer , Berg Christoph P. , Malek Nisar P. , Emrich Marzena H. , Lohrengel Kristina , Ganzenmueller Tina , Iftner Thomas , Kleymann Gerald , Hamprecht Klaus 
Published: March 2022

AbstractHerpes simplex virus 1 (HSV‐1) is a frequently unrecognized, yet deadly cause of acute liver failure (ALF). We, therefore, analysed three cases of fatal HSV‐1‐induced ALF. All patients shared clinical (extremely elevated transaminases, LDH and AST/LDH ratio < 1) and virological characteristics (ratio of viral load in plasma versus throat swabs: 60–700‐fold, lack of anti‐HSV‐1‐IgG antibodies or low IgG‐avidity during primary infection), which may help to identify patients at risk. Additionally, in vitro chemosusceptibility assays revealed high efficacy of the helicase‐primase inhibitors (HPI), pritelivir and drug‐candidate IM‐250 compared to acyclovir (ACV) using HSV‐1‐isolates from two patients; hence, ACV/HPI‐combinations might offer new therapeutic options for HSV‐induced ALF.
Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities
Authors: Ye Zheng , Song Bin , Lee Philip M. , Ohliger Michael A. , Laustsen Christoffer 
Published: March 2022

AbstractHyperpolarized carbon‐13 magnetic resonance imaging (HP 13C MRI) is a recently translated metabolic imaging technique. With dissolution dynamic nuclear polarization (d‐DNP), more than 10 000‐fold signal enhancement can be readily reached, making it possible to visualize real‐time metabolism and specific substrate‐to‐metabolite conversions in the liver after injecting carbon‐13 labelled probes. Increasing evidence suggests that HP 13C MRI is a potential tool in detecting liver abnormalities, predicting disease progression and monitoring response treatment. In this review, we will introduce the recent progresses of HP 13C MRI in diffuse liver diseases and liver malignancies and discuss its future opportunities from a clinical perspective, hoping to provide a comprehensive overview of this novel technique in liver diseases and highlight its scientific and clinical potential in the field of hepatology.
Leadership in internationalization strategies
Authors: Barac Maja , Moner‐Colonques Rafael 
Published: March 2022

AbstractThis paper examines leadership in internationalization strategies for an asymmetric cost duopoly where firms choose between exports and foreign direct investment (FDI) in a sequential setting. The incentive to lead and to engage in FDI is stronger for the more efficient firm. With sequential choices and the efficient firm playing in advance, it is less likely that firms pick identical internationalization strategies in equilibrium, as compared with simultaneous choices; this is more so for greater cost asymmetry. It also happens for large enough oligopoly profitability when the inefficient firm plays in advance. Follow‐the‐leader behaviour in FDI arises for low values of the setup cost. Although entry in FDI by both firms is best for consumers, total welfare can be higher with opposite internationalization strategies. Were firms given the opportunity to lead or wait and enter later, the efficient firm would emerge as the leader in exports/FDI depending on the well‐known proximity‐concentration trade‐off. Interestingly, the less efficient firm might prefer to wait for strategic reasons.
Keratosis pilaris rubra successfully treated with topical sirolimus: Report of a case and review of the literature
Authors: Eckburg Alexandra , Kazemi Tiana , Maguiness Sheilagh 
Published: March 2022

AbstractKeratosis pilaris rubra (KPR) is a subtype of keratosis pilaris (KP) presenting with numerous “grainlike” follicular papules in a background of confluent erythema most often affecting the face and upper extremities with persistence beyond puberty. Treatment has remained challenging with inconsistent benefit from topical therapies such as emollients, keratolytics, corticosteroids, and retinoids, though case reports documenting success with pulsed dye laser therapy have been found. We present a case of KPR in a 15‐year‐old boy who was successfully treated with topical sirolimus 1% cream.
A novel and effective item‐source complex trial protocol: Discrimination of guilty from both knowledgeable and unknowledgeable innocent subjects
Authors: Deng Xiaohong , Liang Xuan , Zhan Xiaofei , Rosenfeld J. Peter , Olson Joseph , Yan Gejun , Xue Chao , Lu Yang 
Published: March 2022

AbstractInnocent subjects who are knowledgeable of crime‐related information will often be misclassified as “guilty” in P300‐based complex trial protocol (CTP). Therefore, it is necessary to develop a more rigorous CTP that can effectively discriminate the guilty from both the knowledgeable and the unknowledgeable innocents. Sometimes the guilty and the knowledgeable innocents possess the same item memories but different source memories. The present study designed a novel item‐source complex trial protocol based on the differences of source memory among the three kinds of individuals. Either the crime‐related probe (e.g., the stolen ring) or one of the crime‐unrelated stimuli (e.g., watch, earring, bracelet, or bangle) (item memory) was presented in the first part of each trail, and either a stealing‐source word (e.g., stole) or other‐source word (e.g., fetched) (source memory) was presented in the second part of each trail. The results showed that: (1) the P300 evoked by item memory could effectively discriminated the guilty from the unknowledgeable innocent (AUC = 0.76) but failed to effectively discriminate the guilty from the knowledgeable innocent (AUC = 0.60); (2) the late positive component evoked by source memory could effectively discriminated the guilty from both the knowledgeable innocent (AUC = 0.94) and the unknowledgeable innocent (AUC = 0.84) in one test.
Modeling and Cascade Control of a Pneumatic Positioning System
Authors: Mandali Anusree , Dong Lili 
Published: March 2022

Abstract
A robust cascade control system based on active disturbance rejection controller (ADRC) is originally developed for accurate position control of a pneumatic servo system, which is usually characterized by nonlinearity, uncertainty, and disturbance. The proposed control system consists of inner and outer control loops. Particularly, a linear ADRC (LADRC) is utilized to adjust valve position for a linear spool valve dynamics in the inner loop. A nonlinear ADRC (NADRC) is designed to control the position of a nonlinear pneumatic actuator subsystem in the outer loop. LADRC and NADRC contain linear and nonlinear extended state observers (ESOs), respectively. The ESO can estimate both unknown nonlinear dynamics and external disturbances and thus make the ADRC robust against system uncertainties and disturbances. Simulation results successfully demonstrate the effectiveness and robustness of the proposed cascade control system. The stabilities of the inner and outer control loops were proved separately using a Lyapunov approach.