bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retroperitoneal mass, a rare manifestation of mucinous adenocarcinoma of appendix: A case report
Authors: Salehipour Mehdi , Haghpanah Abdolreza , Dehghani Anahita , Roozbeh Jamshid , Amirian Armin , Moein vaziri Nader , Kiani Sajad 
Published: November 2022

AbstractThe retroperitoneum (RP) might be affected by a variety of infections, inflammations, and tumors, including benign and malignant ones. Although primary malignant tumors are the most prevalent ones in this anatomic area, metastatic and invasive tumors rarely involve the retroperitoneum. Gastrointestinal stromal tumors (GISTs) are considered as the most common tumors that invade the retroperitoneum, but, to the best of our knowledge, it is the first time a surgery team has encountered the appendiceal tumor as a huge retroperitoneal mass. A 68‐year‐old man was referred to the emergency department with abdominal distension and weight loss. In his course of hospitalization, a huge right retroperitoneal mass was detected by a computed tomography (CT) scan; after that, the patient underwent laparotomy, evacuation of massive mucinous tissue located in the right retroperitoneum, and right hemicolectomy due to appendiceal tumor. The histopathological examination showed “mucinous appendiceal neoplasm.” This is the first case study showing the invasion of an appendiceal tumor through the visceral peritoneum into the retroperitoneum, so an invasion of the peritoneal tumor to the retroperitoneum should be considered when a urologist approaches retroperitoneal masses.
Spontaneous hemothorax in a 10‐year‐old boy with COVID‐19
Authors: Boussetta Abir , Abida Nesrine , Jellouli Manel , Garagah Tahar 
Published: November 2022

AbstractSpontaneous hemothorax occurs in the absence of trauma or iatrogenic causes. Etiologies of spontaneous hemothorax in children include connective tissue disease, neoplasia and coagulopathy, which is associated with thromboembolic events. We present the case of a 10‐year‐old chronic hemodialysis patient with spontaneous hemothorax with a concurrent COVID‐19 infection.
Retroperitoneal mesenchymal chondrosarcoma with metastasis to iliac vein: A rare case report and review of the literature
Authors: Esfahani Mahsa Masjedi , Mirazimi Seyed Mohammad Ali , Azadbakht Javid , Dashti Fatemeh 
Published: November 2022

AbstractThe iliac vein is an extremely rare site of metastasis for extraskeletal mesenchymal chondrosarcoma (ESMC). Involvement of the veins usually leads to an extremely dismal prognosis. Here, we report a 50‐year‐old patient with retroperitoneal mesenchymal chondrosarcoma and initial metastasis to the iliac bone, which further progressed to involve the iliac vein. In this study, we reviewed the major characteristics of ESMC and the previously reported cases, considering the rarity of these tumors.
Hydrogenation Reactions with Synergistic Catalysis of Pd single atoms and nanoparticles under Near‐Ambient Conditions
Authors: Yang Junxia , Yang Li , Zhang Ling , Yu Tie , Zhai Dong , Wang Honglei , Zhou Wei , Li Yajuan , Ren Guoqing , Sun Lei , Deng Weiqiao 
Published: November 2022

AbstractDue to the limited resources and high cost of noble metals, boosting their catalytic activities is highly desired in the current catalysis industry. Here, we report a synergetic catalyst, combining Pd2+ and Pd0 species in a nitrogen‐doped porous carbons (NPC), which shows boosted catalytic activities in hydrogenation reactions of organic nitro compounds (nitrobenzene, 4‐nitrophenol, 1‐nitronaphthalene and 1‐nitropropane) under near ambient conditions. This synergetic catalyst NPC‐[Pd] was synthesized by partial reduction of a palladium‐loaded NPC. The catalytic activities and selectivity of NPC‐[Pd] for hydrogenation were enhanced significantly compared with those of NPC‐Pd2+ or NPC‐Pd0 nanoparticles. Theoretical calculations show that H2 preferentially dissociates on Pd nanoparticles, and then organic molecules (nitrobenzene) can be captured and react with the dissociated H atom on Pd2+ sites. Similar reaction procedure also occur on Pt or Rh. Hydrogenation of different aromatic compounds with different functional groups (naphthalene, 4‐nitrochlorobenzene, benzaldehyde and acetophenone) confirmed the broad excellent catalytic activity of this synergistic catalyst.
A phase 2 trial of chemotherapy plus pembrolizumab in patients with advanced non–small cell lung cancer previously treated with a PD‐1 or PD‐L1 inhibitor: Big Ten Cancer Research Consortium BTCRC‐LUN15‐029
Authors: Salous Tareq , Shukla Nikhil A. , Althouse Sandra K. , Perkins Susan M. , Furqan Muhammad , Leal Ticiana , Traynor Anne M. , Feldman Lawrence E. , Hanna Nasser H. , Durm Greg A. 
Published: November 2022

AbstractBackgroundImmunotherapy using a checkpoint inhibitor (CPI) alone or in combination with chemotherapy is the standard of care for treatment‐naive patients with advanced non–small cell lung cancer (NSCLC) without driver mutations for which targeted therapies have been approved. It is unknown whether continuing CPI treatment beyond disease progression results in improved outcomes.MethodsPatients who experienced progressive disease (PD) after a clinical benefit from chemotherapy plus a CPI were enrolled. Patients received pembrolizumab (200 mg every 3 weeks) plus next‐line chemotherapy. The primary end point was progression‐free survival (PFS) according to the Response Evaluation Criteria in Solid Tumors (version 1.1). Key secondary end points included the overall survival (OS), clinical benefit rate, and toxicity. The authors’ hypothesis was that continuing pembrolizumab beyond progression would improve the median PFS to 6 months in comparison with a historical control of 3 months with single‐agent chemotherapy alone.ResultsBetween May 2017 and February 2020, 35 patients were enrolled. The patient and disease characteristics were as follows: 51.4% were male; 82.9% were current or former smokers; and 74.3%, 20%, and 5.7% had adenocarcinoma, squamous cell carcinoma, and NSCLC not otherwise specified, respectively. The null hypothesis that the median PFS would be 3 months was rejected (p < .05). The median PFS was 5.1 months (95% confidence interval [CI], 3.6–8.0 months). The median OS was 24.5 months (95% CI, 15.6–30.9 months). The most common treatment‐related adverse events were fatigue (60%), anemia (54.3%), and nausea (42.9%). There were no treatment‐related deaths.ConclusionsPembrolizumab plus next‐line chemotherapy in patients with advanced NSCLC who experienced PD after a clinical benefit from a CPI was associated with statistically significant higher PFS in comparison with historical controls of single‐agent chemotherapy alone.
Immobilization of Kluyveromyces lactis β‐Galactosidase on Meso‐macroporous Silica: Use of Infrared Spectroscopy to Rationalize the Catalytic Efficiency
Authors: Videira‐Quintela Diogo , Guillén Francisco , Prazeres Sofia F. , Montalvo Gemma 
Published: November 2022

AbstractEnzyme immobilization on adequate carriers is a challenging strategy. Understanding the enzyme‐carrier interactions and their effects on enzyme conformation and bioactivity is critical. In this study, a meso‐macropores silica (MMS) was used to immobilize β‐galactosidase from the yeast Kluyveromyces lactis (β‐gal‐KL) by physical adsorption. The bioactivity of the immobilized β‐gal‐KL was altered, evidenced by the increased Km, decreased Vmax and kcat, and increased activity at alkaline values. By performing infrared spectroscopy analysis and subsequent secondary structure assessment from the amide I band, the immobilized β‐gal‐KL suffered a β‐sheet (∼31–35 %) to α‐helix (∼15–19 %) transition with increased turns (∼21–22 %) with respect to the free β‐gal‐KL having ∼12 % α‐helix, ∼42 % β‐sheet, and ∼17 % turns. These findings led us to correlate the observed bioactivity performance to structural alterations to a non‐native conformation. The presented line of thought can lead to a better understanding of the reasons causing bioactivity alterations upon enzyme immobilization.
Stability analysis and stabilization of Cuk converter with constant power load
Authors: Hu Wei , Ding Zekang , Yang Hong , Tao Jintong , Wang Xiaogang 
Published: November 2022

AbstractAs one of the important energy conversion systems in renewable energy power generation, the two‐stage DC‐DC converter cascaded system composed of source converter and load converter has been widely used in industrial applications. Different from the constant voltage load of the traditional DC‐DC converter, the load converter in the cascaded converter, as the constant power load of the source converter, has an obvious impact on the stability of the source converter. In this paper, the cascaded system composed of Cuk converter as source converter and buck‐boost converter as load converter is studied. Analyses results show that with increasing of power load, a Floquet multiplier of monodromy matrix belongs to the converter cascaded system traverses the unit circle from outside to inside along negative real axis and will suddenly jump out of the unit circle when the power load reaches a specific value. Correspondingly, the entire system gradually moves from period‐doubling bifurcation state to period‐1 limit cycle and then suddenly jumps to chaos state. With application of monodromy matrix theory and sinusoidal voltage compensation method, stability boundary of the system is extended and nonlinear behaviors are stabilized. Finally, simulation and experimental results verify the feasibility of analytical technique and conclusions.
The ecological diversification and evolution of Teleosauroidea (Crocodylomorpha, Thalattosuchia), with insights into their mandibular biomechanics
Authors: Johnson Michela M. , Foffa Davide , Young Mark T. , Brusatte Stephen L. 
Published: November 2022

AbstractThroughout the Jurassic, a plethora of marine reptiles dominated ocean waters, including ichthyosaurs, plesiosaurs and thalattosuchian crocodylomorphs. These Jurassic ecosystems were characterized by high niche partitioning and spatial variation in dietary ecology. However, while the ecological diversity of many marine reptile lineages is well known, the overall ecological diversification of Teleosauroidea (one of the two major groups within thalattosuchian crocodylomorphs) has never been explored. Teleosauroids were previously deemed to have a morphologically conservative body plan; however, they were in actuality morphofunctionally more diverse than previously thought. Here we investigate the ecology and feeding specializations of teleosauroids, using morphological and functional cranio‐dental characteristics. We assembled the most comprehensive dataset to date of teleosauroid taxa (approximately 20 species) and ran a series of principal component analyses (PC) to categorize them into various feeding ecomorphotypes based on 17 dental characteristics (38 specimens) and 16 functionally significant mandibular characters (18 specimens). The results were examined in conjunction with a comprehensive thalattosuchian phylogeny (153 taxa and 502 characters) to evaluate macroevolutionary patterns and significant ecological shifts. Machimosaurids display a well‐developed ecological shift from: (1) slender, pointed tooth apices and an elongate gracile mandible; to (2) more robust, pointed teeth with a slightly deeper mandible; and finally, (3) rounded teeth and a deep‐set, shortened mandible with enlarged musculature. Overall, there is limited mandibular functional variability in teleosaurids and machimosaurids, despite differing cranial morphologies and habitat preferences in certain taxa. This suggests a narrow feeding ecological divide between teleosaurids and machimosaurids. Resource partitioning was primarily related to snout and skull length as well as habitat; only twice did teleosauroids manage to make a major evolutionary leap to feed distinctly differently, with only the derived machimosaurines successfully radiating into new feeding ecologies.
Use of a solid‐state nanopore for profiling the transferrin receptor protein and distinguishing between transferrin receptor and its ligand protein
Authors: O'Donohue Matthew , Saharia Jugal , Bandara Nuwan , Alexandrakis Georgios , Kim Min Jun 
Published: November 2022

AbstractA nanopore device is capable of providing single‐molecule level information of an analyte as they translocate through the sensing aperture—a nanometer‐sized through‐hole—under the influence of an applied electric field. In this study, a silicon nitride (SixNy)‐based nanopore was used to characterize the human serum transferrin receptor protein (TfR) under various applied voltages. The presence of dimeric forms of TfR was found to decrease exponentially as the applied electric field increased. Further analysis of monomeric TfR also revealed that its unfolding behaviors were positively dependent on the applied voltage. Furthermore, a comparison between the data of monomeric TfR and its ligand protein, human serum transferrin (hSTf), showed that these two protein populations, despite their nearly identical molecular weights, could be distinguished from each other by means of a solid‐state nanopore (SSN). Lastly, the excluded volumes of TfR were experimentally determined at each voltage and were found to be within error of their theoretical values. The results herein demonstrate the successful application of an SSN for accurately classifying monomeric and dimeric molecules while the two populations coexist in a heterogeneous mixture.
On‐chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva
Authors: Hamilton Sean , Shea Delaney , Ibsen Stuart , Brasino Michael 
Published: November 2022

AbstractEarly detection has led to increased survival for multiple cancers; however, the 5‐year survival rate of oral carcinoma (OC) has remained at 40% for the last several decades. Screening for OC is routinely done via visual examinations, followed by tissue biopsy and laboratory testing. Point‐of‐care testing would be a more convenient and widely available alternative for at‐risk individuals. Increased lactate production is a hallmark of many head‐and‐neck tumors, due to the Warburg Effect, where tumor cells favor glycolysis in the place of oxidative phosphorylation. To detect excess lactate, we have modified the commensal bacterium Escherichia coli Nissle 1917 to express fluorescent reporter genes in response to extracellular lactate. Administering this commensal as a mouth wash and subsequently collecting saliva for the detection of the reporter may allow for noninvasive, early detection of cancerous lesions in at‐risk individuals. Furthermore, we demonstrate a new on‐chip electrokinetic technique to recover these probiotic probes from model saliva fluid to improve the detection of reporter gene activation.
Frequency regulation optimization for wind storage based on frequency regulation reliability and state of charge in isolated island off‐grid
Authors: Chen Changqing , Wang Yali , Zhou Kui , Huang Zhiliang 
Published: November 2022

AbstractTo further improve the frequency regulation stability of wind farm, and optimize the state of charge (SOC) basepoint, charge and discharge rate and recovery capacity of energy storage. In an isolated, off‐grid state, a two‐layer optimization method is proposed, taking into account the frequency regulation reliability and SOC adaptive adjustment of the wind storage. In the upper layer, the model predictive control theory is adopted to optimize the energy‐storage frequency regulation output power with the goal of minimizing the wind storage frequency regulation power deviation. While solving the problem of low‐frequency regulation reliability of wind farm, the SOC recovery basepoint and frequency regulation power of energy storage are optimized. At the SOC optimization layer, based on the upper SOC recovery basis point, we propose a dynamic recovery method for energy‐storage SOC that considers both the SOC recovery demand and grid‐bearing capacity, to determine the energy‐storage recovery power. By determining the frequency regulation or recovery power, we propose a calculation method to optimize the energy‐storage charge and discharge coefficients as per the SOC for avoiding excessive charging and discharging. The simulation results show that, under continuous disturbance, the root‐mean‐square deviations of the proposed method is 80.13% and 62.63% lower than those of the fixed K and SOC methods, respectively. Furthermore, the proposed method exhibits the best SOC maintenance effect.
Modulation of cortical beta oscillations influences motor vigor: A rhythmic TMS‐EEG study
Authors: Uehara Kazumasa , Fine Justin M. , Santello Marco 
Published: November 2022

AbstractPrevious electro‐ or magnetoencephalography (Electro/Magneto EncephaloGraphic; E/MEG) studies using a correlative approach have shown that β (13–30 Hz) oscillations emerging in the primary motor cortex (M1) are implicated in regulating motor response vigor and associated with an anti‐kinetic role, that is, slowness of movement. However, the functional role of M1 β oscillations in regulation of motor responses remains unclear. To address this gap, we combined EEG with rhythmic TMS (rhTMS) delivered to M1 at the β (20 Hz) frequency shortly before subjects performed an isometric ramp‐and‐hold finger force production task at three force levels. rhTMS is a novel approach that can modulate rhythmic patterns of neural activity. β‐rhTMS over M1 induced a modulation of neural oscillations to β frequency in the sensorimotor area and reduced peak force rate during the ramp‐up period relative to sham and catch trials. Interestingly, this rhTMS effect occurred only in the large force production condition. To distinguish whether the effects of rhTMS on EEG and behavior stemmed from phase‐resetting by each magnetic pulse or neural entrainment by the periodicity of rhTMS, we performed a control experiment using arrhythmic TMS (arTMS). arTMS did not induce changes in EEG oscillations nor peak force rate during the rump‐up period. Our results provide novel evidence that β neural oscillations emerging the sensorimotor area influence the regulation of motor response vigor. Furthermore, our findings further demonstrate that rhTMS is a promising tool for tuning neural oscillations to the target frequency.
Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta‐analysis
Authors: Wang Dong , Liao Mange , Wu Jian , Luo Wenlong , Qi Siguo , Liu Bo , Li Jiarong 
Published: November 2022

AbstractThe present study aimed to evaluate the effectiveness and safety of various salvage treatments to treat locally recurrent nasopharyngeal carcinoma (IrNPC). A comprehensive search was conducted to gather relevant research publications on salvage treatment for IrNPC. Specifically, 2‐, 3‐, and 5‐year overall survival were the primary outcome. A total of 89 studies with 101 cohorts were collected. Endoscopic nasopharyngectomy was found to be associated with a significantly improved 5‐year OS compared with CRT (p = 0.027) and IMRT (p = 0.016). Moreover, based on recurrence T classification, the 2‐, 3‐, and 5‐year OS were similar across different treatments. Endoscopic nasopharyngectomy was associated with a significant reduction in treatment‐related complications (grade ≥ 3) compared with IMRT (p < 0.001) and open nasopharyngectomy (p = 0.028). Endoscopic nasopharyngectomy may provide comparable treatment outcomes to re‐irradiation, while offering a better safety profile for selective patients with resectable IrNPC.
The earthquake's effect on the men's sexual function; 1 year after the earthquake's occurrence: A cross‐sectional study
Authors: Ebrahimian Abbasali , Babaei Hossein 
Published: November 2022

AbstractBackground and AimsSexual dysfunctions are one of the health problems after natural disasters that are usually less attention. The purpose of this study was to evaluate the effect of the earthquake on men's sexual functions 1 year after the earthquake.MethodsThis study was a descriptive‐analytical cross‐section study that took place a year after the Kermanshah earthquake. The population studied was all men living in the Kermanshah earthquake. Demographic, socioeconomic, psychological, health situations, facilities availability, and environmental situations after the earthquake and International Index of Erectile Function (IIEF) were randomly distributed among men affected by the earthquake. Participants returned the questionnaires through the mail. Based on the IIEF cut‐point score, men were divided into two groups: those with sexual dysfunction (Group A) and without sexual dysfunction (Group B).ResultsIn this study, 225 married men participated. The prevalence of sexual dysfunction in earthquake‐affected men was 44.9%. The mean total IIEF scores in the A and B groups were 43.47 ± 7.82 and 62.11 ± 6.39, respectively. There was a significant difference between the total and all subcategories IIEF scores in the two groups (p < 0.001). There was a statistically significant difference between the age (p < 0.001), child numbers (p < 0.017), current live location (p < 0.001), social support after the earthquake (p = 0.033), underlying disease (p < 0.001), availability of sanitary toilets (p < 0.001) and bathrooms (p = 0.002), and total IIEF scores between the two groups (p < 0.001).ConclusionsApproximately half of the earthquake‐affected men had sexual dysfunctions. The men's age, child numbers, current live location, social support, underlying disease, and availability of sanitary toilets and bathrooms were influential in the severity of men's sexual dysfunctions after the earthquake. Therefore, crisis managers, policymakers, psychiatrists, and psychologists should pay enough attention to men's sexual dysfunction after earthquakes.
Impact of COVID‐19 pandemic on reproductive, maternal, newborn, and child health care services in Phuentsholing General Hospital: A retrospective descriptive study
Authors: Dorjey Yeshey , Tshomo Yezer , Wangchuk Dorji , Bhandari Purushottami , Dorji Choki , Pradhan Diptika , Pemo Rinzin , Wangdi Phub 
Published: November 2022

AbstractBackgroundCOVID‐19 pandemic has derailed health care services. The health resources and manpower were prioritized and diverted to curb the COVID‐19 infections at the cost of routine medical services to the people. The impact of the COVID‐19 pandemic on maternal and child health is unknown. This study aimed to assess the impact of the Covid‐19 pandemic on maternal and child health care services in Phuentsholing General Hospital.MethodsA descriptive retrospective study was conducted at Phuentsholing General Hospital from January 1 to June 30, 2022. The patient medical records were reviewed for the prepandemic years 2018, and 2019, and the pandemic years 2020, and 2021. The medical records of all the female patients and newborns who came to the Maternal and Child Health Unit (MCH), those who were admitted to the gynecology ward, and who underwent obstetrical and gynecological surgeries were reviewed. The data were analyzed using SPSS version 23. Descriptive statistics such as frequencies and percentages were used to describe the study variables. The line graph and bar graph were used to determine the trends and to compare the impact of COVID‐19 on MCH services between the pre‐pandemic and pandemic years.ResultsDuring the COVID‐19 pandemic, the total admission dropped by 10% to 14.4%; the total deliveries dropped by 16.1%; Cesarean section rate dropped to 12.9%; and fewer gynecological surgeries were performed (13.9% from 20.6%). There was a significant drop in antenatal and postnatal follow‐up visits (31.5% and 24.51%) respectively; Pap smear dropped by 93% and colposcopy by 52%. The overall immunization coverage has dropped drastically during the pandemic period.ConclusionThe pregnant mothers and newborn babies missed antenatal and postnatal follow‐up visits, missed immunization, and women were not able to be screened for cervical cancers during the pandemic. These negative impacts of the COVID‐19 pandemic on maternal and child health care were profound.