bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction vibration risk assessment of engineering projects based on nonlinear feature algorithm
Authors: Liu Li 
Published: November 2022

Abstract
In order to study the vibration engineering project construction risk assessment, algorithms based on nonlinear characteristics, a nonlinear feature extraction local linear embedding (LLE) combined with adaptive neuro-fuzzy inference system (ANFIS) assessment of risk assessment methods have been proposed. This method is first utilized by the LLE manifold method to extract a number of sample construction vibration risk assessment factors of high-dimensional data vector of the nonlinear components. The nonlinear component is then used as the input for ANFIS evaluation method to evaluate and classify construction vibration risk samples. An example shows that this method can effectively improve the accuracy of risk assessment and reduce the error rate to less than 10%. Applying it to practical projects can provide effective decision-making information for construction managers and improve the credibility of decision-making. The identification results prove that the method in this article improves the accuracy of feature extraction and vibration risk assessment, and can as a vibration risk assessment method, be applied to the actual engineering vibration risk assessment.
Impact of the convergent geometric profile on boundary layer separation in the supersonic over-expanded nozzle
Authors: Dehane Rabie , Naima Khatir , Liazid Abdelkrim , Inc Mustafa , Benarous Abdallah , Ahmad Hijaz , Menni Younes 
Published: November 2022

AbstractThis article aims to conduct a numerical investigation of phenomena induced by gas expansion in chemical propulsion nozzles. A numerical simulation of full-scale flat convergent-divergent nozzle geometry using the finite volume method on structured meshes is performed to predict the change in the convergent geometry on the boundary layer separation resulting from a shock/shock and shock/boundary layer. Two turbulence models are tested, namely, thek−εandk−ωshear-stress transport (SST) models. Three steps are considered to achieve this work. First, 10 numerical schemes are tested to select the accurate one. The findings of the first step are used to predict the boundary layer separation in a supersonic overexpanded nozzle. The available experimental data from the NASA Langley Research Center are used to validate the results. The third step concerns investigating the impact of the convergent geometric profile on the downstream flow of the nozzle. The obtained results are analyzed and compared with the experimental data. These results show that convergent geometry may cause the formation of different shock structures and different points of flow separation and modifies several parameters of the flow and nozzle performance downstream the throat. The findings indicated that the convergent profile must be considered during the design phase when focusing on the problem of boundary layer separation in the supersonic overexpanded regime nozzles.
In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera
Authors: Aljubiri Salha M. , Elsalam Eman Abd , Abd El Hady Faten K. , Radwan Mohamed O. , Almansour Abdulrahman I. , Shaker Kamel H. 
Published: November 2022

Abstract
Acetylcholinesterase, tyrosinase, and α-glucosidase inhibition activities of Euphorbia schimperiana and Euphorbia balsamifera extracts, fractions, and available pure compounds were evaluated for the first time. Acetylcholinesterase assay revealed a significant inhibitory activity of E. balsamifera total extract and n-hexane fraction with 47.7% and 43.3%, respectively, compared to the reference drug, which was 75%. The n-butanol fraction demonstrated tyrosinase inhibitory activity for E. balsamifera and E. schimperiana with 36.7% and 29.7%, respectively, compared to 60% for the reference drug. Quercetin-3-O-α-glucuronide, quercetin-3-O-β-D-glucuronide-methyl ester, quercetin-3-O-α-L-rhamnoside, 3,3′-di-O-methyl ellagic acid, 3,3′-di-O-methyl-ellagic acid-4-β-D-xylopyranoside, and 4-O-ethyl gallic acid were identified from E. schimperiana while quercetin-3-O-glucopyranoside and isoorientin were determined from E. balsamifera. The AChE inhibitory effect of pure compounds exhibited promising activity, where 4-O-ethylgallic acid demonstrated 51.1%, while the highest tyrosinase inhibition was demonstrated by isoorientin with 50.6% compared to the reference drug (60%). Finally, a molecular docking study was performed for the most promising AChE and tyrosinase inhibitors. The extracts, fractions, and isolated compounds showed no α-glucosidase inhibitory activity.
Zebrafish: An Emerging Model for Studying Macrophage Functions in Cancer
Authors: Guo Xiuting , Jiang Linjia 
Published: November 2022

Abstract
Zebrafish provide a convenient and unique model for studying human cancers, owing to the high similarity between zebrafish and human genomes, the availability of genetic manipulation technologies, and the availability of large numbers and transparency of zebrafish embryos. Many researchers have recently used zebrafish cancer models to examine the functions of macrophages in tumorigenesis, tumor growth and metastasis. Here, we present evidence that zebrafish cancer cells produce signals that are conserved with respect to those in humans and lead to the recruitment of heterogeneously activated macrophages in response to specific tumor types and tumorigenic stages, thereby promoting cancer initiation and progression. We also summarize how cancer cells interact with macrophages, emphasizing live imaging studies for visualization of dynamic material interchange.
Spatiotemporal Atlas of the Fetal Brain Depicts Cortical Developmental Gradient
Authors: Xu Xinyi , Sun Cong , Sun Jiwei , Shi Wen , Shen Yao , Zhao Ruoke , Luo Wanrong , Li Mingyang , Wang Guangbin , Wu Dan 
Published: November 2022

The fetal brains experience rapid and complex developmentin uteroduring the second and third trimesters.In uteroMRI of the fetal brain in this period enables us to quantify normal fetal brain development in the spatiotemporal domain. In this study, we established a high-quality spatiotemporal atlas between 23 and 38 weeks gestational age (GA) from 90 healthy Chinese human fetuses of both sexes using a pairwise and groupwise registration pipeline. We quantified the fetal cortical morphology indices and characterized their spatiotemporal developmental pattern. The cortical thickness exhibited a biphasic pattern that first increased and then decreased; the curvature fitted well into the Gompertz growth model; sulcal depth increased linearly, while surface area expanded exponentially. The cortical thickness and curvature trajectories consistently pointed to a characteristic time point around GA of 31 weeks. The characteristic GA and growth rate obtained from individual cortical regions suggested a central-to-peripheral developmental gradient, with the earliest development in the parietal lobe, and we also observed a superior-to-inferior gradient within the temporal lobe. These findings may be linked to biophysical events, such as dendritic arborization and thalamocortical fibers ingrowth. The proposed atlas was also compared with an existing fetal atlas from a white/mixed population. Finally, we examined the structural asymmetry of the fetal brains and found extensive asymmetry that dynamically changed with development. The current study depicted a comprehensive profile of fetal cortical development, and the established atlas could be used as a normative reference for neurodevelopmental and diagnostic purposes, especially in the Chinese population.SIGNIFICANCE STATEMENTWe generated a high-quality 4D spatiotemporal atlas of the normal fetal brain development from 23 to 38 gestational weeks in a Chinese population and characterized the spatiotemporal developmental pattern of cortical morphology. According to the cortical development trajectories, the fetal cerebral cortex development follows a central-to-peripheral developmental gradient that may be related to the underlying cellular events. The majority of cortical regions already exhibit significant asymmetry during the fetal period.
Intestinal Apc‐inactivation induces HSP25 dependency
Authors: van Neerven Sanne M , Smit Wouter L , van Driel Milou S , Kakkar Vaishali , de Groot Nina E , Nijman Lisanne E , Elbers Clara C , Léveillé Nicolas , Heijmans Jarom , Vermeulen Louis 
Published: November 2022

AbstractThe majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation, cytoskeletal remodeling, and a global increase in mRNA translation. To compensate for the increased biosynthetic demand, cancer cells critically depend on protein chaperones to maintain proteostasis, although their function in CRC remains largely unexplored. In order to investigate the role of molecular chaperones in driving CRC initiation, we captured the transcriptomic profiles of murine wild type and Apc‐mutant organoids during active transformation. We discovered a strong transcriptional upregulation of Hspb1, which encodes small heat shock protein 25 (HSP25). We reveal an indispensable role for HSP25 in facilitating Apc‐driven transformation, using both in vitro organoid cultures and mouse models, and demonstrate that chemical inhibition of HSP25 using brivudine reduces the development of premalignant adenomas. These findings uncover a hitherto unknown vulnerability in intestinal transformation that could be exploited for the development of chemopreventive strategies in high‐risk individuals.
Recycling routes of lithium-ion batteries: A critical review of the development status, the process performance, and life-cycle environmental impacts
Authors: Wagner-Wenz Ronja , van Zuilichem Albert-Jan , Göllner-Völker Laura , Berberich Katrin , Weidenkaff Anke , Schebek Liselotte 
Published: November 2022

AbstractToday, new lithium-ion battery-recycling technologies are under development while a change in the legal requirements for recycling targets is under way. Thus, an evaluation of the performance of these technologies is critical for stakeholders in politics, industry, and research. We evaluate 209 publications and compare three major recycling routes. An important aspect of this review is that we tackle the need for a critical evaluation of these recycling routes by introducing clear terms and creating a structuring scheme. Our evaluation criteria cover three areas: status of development, process performance, and life-cycle environmental impacts. With respect to development status, we provide an analysis of today’s market. A criterion of process performance is recycling efficiency, which today focuses on the mass of the recovered materials. To include the contributions of critical materials, we add a criterion for the efficiency of recovery of materials. Life-cycle assessments provide information on gross impacts, benefit of substituting virgin material and net impact. Present life-cycle assessments focus on waste management rather than on recovery of critical materials. This review contributes to an understanding of these trade-offs and supports discussion as to what is the “best” recycling route when targets conflict.
Graphical Abstract
There are three possible process sequences for each lithium-ion battery-recycling route. A distinction is made between pre-treatment steps (gray), direct physical treatment steps (green), pyro-metallurgical treatment (orange), and hydro-metallurgical treatment (blue). The figure is based on a figure from Doose et al. (Joule 3:2622–2646, 2019).
Microsporia in Young Children: Clinical Cases
Authors: Yakovlev Alexey B. , Polonskaya Aleksandra S. , Kruglova Larisa S. 
Published: November 2022

Background. Microsporia is a zooanthroponotic mycosis of skin and hair caused by fungi genus Microsporum. Microsporia is most common among children, including infants. The microsporia incidence has slow steady increase over recent years.Clinical cases description. Follow-up results of two children of different ages (younger/older than 1 year) with microsporia are presented. Successful management approach is shown. Major limitations of drug therapy in infants as well as common therapeutic errors were analyzed.Conclusion. Diagnosis and management of microsporia in infants and young children is a challenging task. Major errors in microsporia management in patients of these age groups are associated with peculiarities of clinical picture as well as limited variations of drugs that are appropriate for the requirements on efficacy and safety of therapy among young children.
Physical Development and Puberty in Related Patients with Kindler Epidermolysis Bullosa: Case Study
Authors: Leonova Maria A. , Murashkin Nikolay N. , Dvornikov Anton S. , Pronina Irina Yu. 
Published: November 2022

Background. Kindler epidermolysis bullosa is orphan, autosomal recessive disease and it is one of the variants of congenital epidermolysis bullosa. Its severe course is characterized by high risk of multifactorial malnutrition, chronic inflammation due to recurrent secondary skin infections, and also bone metabolism disorders, what can lead to disorders in physical development and puberty in children. However, the effect of Kindler epidermolysis bullosa on patients’ physical development and puberty remains unexplored.Clinical case description. Family case of Kindler epidermolysis bullosa was presented in 13 and 12 years old patients, third degree of kinship (maternal, uncle — nephew) with typical clinical manifestations for this disease. The diagnosis was confirmed in both patients via Sanger sequencing and revealing identical pathogenic variants in the FERMT1 gene (two deletions in the compound-heterozygous state — c.778del, p.Q260Kfs*21 and c.1088del, p. L363Wfs*39). Reduced concentrations of testosterone and 25(OH)D were revealed, whereas, increased concentration of adrenocorticotropic hormone — only in the older patient. The concentrations of luteinizing hormone, follicle-stimulating hormone and estradiol in both patients were within the reference values. The younger patient had prepubertal sizes and volume of testicles. Both patients had specific features of psychoemotional state: mood swing with rapid increase in anxiety level in the older patient and difficulties in emotional-volitional regulation in younger one.Conclusion. Patients with Kindler epidermolysis bullosa have high risk of physical development and puberty delay due to its systemic chronic pathological process. Thus, these patients require dynamic follow-up by pediatrician and pediatric endocrinologist.
Serum Sickness-Like Reaction Associated with Epstein – Barr Virus: Clinical Case
Authors: Ivanchikov Vladislav V. , Murashkin Nikolay N. , Ambarchian Eduard T. , Kuzminova Anastasia D. 
Published: November 2022

Background. Annular dermatoses are a group of diseases with major clinical manifestation of rashes of relevant form. This manifestation pattern causes difficulties in diagnosis. The case of rarely diagnosed annular dermatosis is presented: serum siknesslike reaction (SSLR) triggered by the Epstein – Barr virus (EBV).Clinical case description. Patient D., 8 years old girl, noted abdominal pain 3 weeks before hospitalization, and later numerous polymorphic rashes (erythematous macules, urticarial elements), swelling and pain in joints. Self-treatment with non-steroidal anti-inflammatory and systemic antihistamines did not lead to any improvement. The patient was hospitalized in the pediatric department at the place of residence, where the diagnosis “Henoch-Schonlein purpura, mixed type” was established according to the results of physical, laboratory (double increase of ALT and AST, ESR up to 166 mm/h, IgM to EBV), and ultrasound (mesenteric lymph nodes hyperplasia) studies. Systemic glucocorticosteroids have led to improvement, however, few days after the end of the treatment there was relapse of rash and arthralgia. Thus, the girl was administrated to clinical diagnostic center. Patient’s general condition was satisfactory at the time of examination. There were numerous erythematous annular urticarial and macular elements (3–12 cm) on the skin of face, body and limbs. Some foci, as well as some resolved rashes had blue spots with indistinct boundaries that disappeared after compression. Mucous membranes, nails and hair were intact. Subjective symptoms — slight burning around rashes, at palpation — low-intensity pain in the left radiocarpal joint. Blood tests: C-reactive protein concentration increased up to 12 mg/L, ESR up to 26 mm/h, IgG to EBV up to 47.7.Conclusion. During differential diagnosis we should consider the possibility of SSLR development in all pediatric patients with annular rashes associated with arthralgia and/or arthritis, fever, history of drug use (most often beta-lactam antibiotics), recent vaccination or manifestations of viral infection, especially in case of cyanotic spots after rashes resolution and non-specific laboratory parameters.
Administration Details of Genetically Engineered Biologic Drug (Ustekinumab) in Children with Psoriasis and Comorbid Metabolic Syndrome or in Case of Previous Biological Therapy Failure: Case Studies
Authors: Ivanov Roman A. , Murashkin Nikolay N. 
Published: November 2022

Background. Psoriasis is a chronic immune-mediated disease with multifactorial nature. It often requires administration of genetically engineered biologic drugs. They have a number of features and risks that depend on various factors. The results of ustekinumab administration as a drug of choice in patients with comorbid metabolic syndrome in a child with Down syndrome, as well as a case of inefficacy of previous biologic therapy with inhibitors are considered.Clinical cases description. Two clinical cases of ustekinumab administration in children with severe psoriasis have been described. In the first case, we had to choose systemic therapy for the child suffering from Down syndrome and having complex comorbid background: obesity and steatohepatitis. The second case was interesting due to the family history of psoriasis in the patient, who received methotrexate for a long time, and then etanercept with subsequent loss of efficacy and severe disease aggravation without any pathogenetic therapy.Conclusion. Ustekinumab is the favorable genetically engineered biologic drug (according to the studies results and the clinical cases data) for children with severe psoriasis who have comorbid pathologies and who require the change in biologic agent due to its inefficacy.
Getting to “No” You
Authors: Rafieyan Roia 
Published: November 2022

Nonspeaking autistic people frequently begin music therapy at the request of others. Typically, family or care systems are tasked with making decisions on their behalf and have decided this service will be of benefit. Consequently, music therapy is a given rather than a choice. For this paper I have used my own evolving understanding to explore the complexities and power dynamics related to nonspeaking people being able to say “no” to music therapy. Elements in this discussion include: (a) the ability, and safety, to say “no” in the context of a culture of compliance, (b) the complicated relationship between music therapists and the systems within which they work, and how this affects the therapy relationship, and (c) the role of music therapy practice standards. I advocate the following: (1) presume competence, (2) enter the therapy space with curiosity and openness, (3) be willing to “get to know,” (4) coping skills or communication attempts are not “behavior” in need of correction, and (5) learn how each nonspeaking person communicates “no.” Actively encouraging and respecting treatment refusal goes a long way toward building a respectful music therapy practice/relationship.
Lateral medullary syndrome: an unwanted ischemia to identify early
Authors: Prajjwal Priyadarshi , Inban Pugazhendi , Nagre Abhijit , Shah Mujtaba Hussain , Chaudhary Ansh , Ranjan Raunak , Chaudhary Bhupendra 
Published: November 2022

Lateral medullary syndrome also referred to as Wallenberg syndrome, posterior inferior cerebellar artery (PICA) syndrome, or vertebral artery syndrome is a cluster of neurological symptoms and signs brought on by obstructions in the blood vessels supplying the medulla, which causes ischemia or infarction of the brainstem. The vertebral artery or the posterior inferior cerebellar artery are the arteries most frequently affected with lateral medullary syndrome. The most prevalent symptom is transient ischemic attack (TIA) with dizziness or vertigo and atherosclerosis in the posterior cerebral circulation being the most common cause. Lateral Medullary Syndrome patients suffer from strokes or infarction and also present with vomiting, nausea, gait impairment, instability, hoarseness, and swallowing difficulties. Depending on the particular nuclei and fibers involved, different indications will appear. CT/MRI imaging is used to diagnose conditions. The majority of management is supportive, including risk factor reduction for additional ischemia events as well as speech and occupational therapy following an acute intervention. In this review article, we discuss the etiopathogenesis and factors leading to lateral medullary syndrome along with a comprehensive discussion on its clinical features, challenges in diagnosis, and treatment.
New species records in Acanthagrion, Nehalennia, and Perilestes (Odonata: Zygoptera) for Colombia
Authors: Alvarez Karen , Bota-Sierra Cornelio Andrés , Vásquez-Ramos Jesús Manuel 
Published: November 2022

We record for the first time Acanthagrion jessei, Nehalennia minuta, and Perilestes solutus in Colombia, based on males and females taken at the campus Barcelona at the Universidad de Los Llanos, located in the foothills of the Colombian Eastern Andes in the Orinoco river basin.