bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstruction of time-shifted hemodynamic response
Authors: Herrnberger Bärbel 
Published: October 2022

AbstractRegression of voxel time course onto expected response is a standard procedure in functional magnetic resonance imaging that relies on exact onset time and shape of superimposed hemodynamic response functions. Elegant capture of time deviation by time derivative regressors appears complicated by shape distortion and limited to ±1 s, and is usually not exploited for reconstructing the true time-shifted response function together with its magnitude. This analysis of the time-derivative approach provides closed-form functional relations between time shift and regression coefficients that allow for hemodynamic shifts of ±5 s and can explain shape distortion and reconstruction behavior. Reliable absolute latencies were no smaller than 0.6 s in a best-case experiment. Confusions of latency are a previously undiscussed shortcoming where current limitation strategy may eliminate correct latencies and protect incorrect ones.
Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
Authors: Oettinger Vera , Heidenreich Adrian , Kaier Klaus , Zehender Manfred , Bode Christoph , Duerschmied Daniel , von zur Mühlen Constantin , Westermann Dirk , Stachon Peter 
Published: October 2022

AbstractThe literature has shown an inverse volume-outcome relationship for transcatheter aortic valve implantation (TAVI). However, little is known about emergency admissions in Germany. Using German national electronic health records, we identified all isolated balloon-expandable and self-expanding transfemoral TAVI in 2018. The focus was on those patients with emergency admission. 17,295 patients were treated with TAVI, including 1682 emergency cases. 49.2% of the emergency admissions were female, the mean age was 81.2 years and the logistic EuroSCORE was 23.3%. The percentage of emergency cases was higher in lower volume than in higher volume centers (p < 0.001): In detail, centers performing < 50 TAVI showed an emergency admission rate of ~ 15%, those with > 200 TAVI a rate of ~ 11%. After propensity score adjustment, analyzing the outcomes for an increase in volume per 10 emergency admissions, higher volume centers showed significantly better outcomes regarding in-hospital mortality (OR = 0.872, p = 0.043), major bleeding (OR = 0.772, p = 0.001), stroke (OR = 0.816, p = 0.044), mechanical ventilation > 48 h (OR = 0.749, p = 0.001), length of hospital stay (risk adjusted difference in days of hospitalization per 10 emergency admissions: − 1.01 days, p < 0.001), and reimbursement (risk adjusted difference in reimbursement per 10 emergency admissions: -€314.89, p < 0.001). Results were not significant for acute kidney injury (OR = 0.951, p = 0.104), postoperative delirium (OR = 0.975, p = 0.480), and permanent pacemaker implantation (OR = 1.010, p = 0.732). In conclusion, regarding transfemoral TAVI, the percentage of emergency cases was higher in lower volume centers in Germany. However, higher volume centers show significantly better outcomes for in-hospital mortality and complication rates as well as resource utilization parameters.
The use of PLANS and NetworkX in modeling power grid system failures
Authors: Hadaj Piotr , Strzałka Dominik , Nowak Marek , Łatka Małgorzata , Dymora Paweł 
Published: October 2022

AbstractThe theoretical and practical aspects and results of simulations based on a specialized tool that is used in the energy industry were adressed. The previously discussed cases in the literature by taking into account the worst case and critical states of networks in terms of complex networks were extended. Using the Monte-Carlo method, the vulnerability of the power grid to node failures was investigated, both in terms of the use of specialized software, which is used in the power industry, and a tool for the analysis of complex networks graphs. We present the results obtained and the observed analogy between the results of the analysis performed in specialized software and the complex network graph analysis tool. It has been shown that the results obtained coincide for both software packages, even though their application focuses on slightly different aspects of system operation. Moreover, further possibilities of extending the research in this direction are proposed, taking into account not only the improvement of the method used, but also a significant increase in the size of the tested structure model.
Defining digital surgery for the future
Authors: Raza Marium M. , Venkatesh Kaushik P. , Diao James A. , Kvedar Joseph C. 
Published: October 2022

AbstractInnovations in robotics, virtual and augmented reality, and artificial intelligence are being rapidly adopted as tools of “digital surgery”. Despite its quickly emerging role, digital surgery is not well understood. A recent study defines the term itself, and then specifies ethical issues specific to the field. These include privacy and public trust, consent, and litigation.
An integrated transcriptome mapping the regulatory network of coding and long non-coding RNAs provides a genomics resource in chickpea
Authors: Jain Mukesh , Bansal Juhi , Rajkumar Mohan Singh , Garg Rohini 
Published: October 2022

AbstractLarge-scale transcriptome analysis can provide a systems-level understanding of biological processes. To accelerate functional genomic studies in chickpea, we perform a comprehensive transcriptome analysis to generate full-length transcriptome and expression atlas of protein-coding genes (PCGs) and long non-coding RNAs (lncRNAs) from 32 different tissues/organs via deep sequencing. The high-depth RNA-seq dataset reveal expression dynamics and tissue-specificity along with associated biological functions of PCGs and lncRNAs during development. The coexpression network analysis reveal modules associated with a particular tissue or a set of related tissues. The components of transcriptional regulatory networks (TRNs), including transcription factors, their cognatecis-regulatory motifs, and target PCGs/lncRNAs that determine developmental programs of different tissues/organs, are identified. Several candidate tissue-specific and abiotic stress-responsive transcripts associated with quantitative trait loci that determine important agronomic traits are also identified. These results provide an important resource to advance functional/translational genomic and genetic studies during chickpea development and environmental conditions.
Nonlinear Hall effects in strained twisted bilayer WSe2
Authors: Hu Jin-Xin , Zhang Cheng-Ping , Xie Ying-Ming , Law K. T. 
Published: October 2022

AbstractRecently, it has been pointed out that the twisting of bilayer WSe2 would generate topologically non-trivial flat bands near the Fermi energy. In this work, we show that twisted bilayer WSe2 (tWSe2) with uniaxial strain exhibits a large nonlinear Hall (NLH) response due to the non-trivial Berry curvatures of the flat bands. Moreover, the NLH effect is greatly enhanced near the topological phase transition point which can be tuned by a vertical displacement field. Importantly, the nonlinear Hall signal changes sign across the topological phase transition point and provides a way to identify the topological phase transition and probe the topological properties of the flat bands. The strong enhancement and high tunability of the NLH effect near the topological phase transition point renders tWSe2 and related moire materials available platforms for rectification and second harmonic generations.
Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
Authors: Martin William P. , Nair Meera , Chuah Yeong H.D. , Malmodin Daniel , Pedersen Anders , Abrahamsson Sanna , Hutter Michaela , Abdelaal Mahmoud , Elliott Jessie A. , Fearon Naomi , Eckhardt Hans , Godson Catherine , Brennan Eoin P. , Fändriks Lars , le Roux Carel W. , Docherty Neil G. 
Published: October 2022

Abstract
The attenuation of diabetic kidney disease (DKD) by metabolic surgery is enhanced by pharmacotherapy promoting renal fatty acid oxidation (FAO). Using the Zucker Diabetic Fatty and Zucker Diabetic Sprague Dawley rat models of DKD, we conducted studies to determine if these effects could be replicated with a non-invasive bariatric mimetic intervention. Metabolic control and renal injury were compared in rats undergoing a dietary restriction plus medical therapy protocol (DMT; fenofibrate, liraglutide, metformin, ramipril, and rosuvastatin) and ad libitum-fed controls. The global renal cortical transcriptome and urinary 1H-NMR metabolomic profiles were also compared. Kidney cell type-specific and medication-specific transcriptomic responses were explored through in silico deconvolution. Transcriptomic and metabolomic correlates of improvements in kidney structure were defined using a molecular morphometric approach. The DMT protocol led to ∼20% weight loss, normalized metabolic parameters and was associated with reductions in indices of glomerular and proximal tubular injury. The transcriptomic response to DMT was dominated by changes in fenofibrate- and peroxisome proliferator-activated receptor-α (PPARα)-governed peroxisomal and mitochondrial FAO transcripts localizing to the proximal tubule. DMT induced urinary excretion of PPARα-regulated metabolites involved in nicotinamide metabolism and reversed DKD-associated changes in the urinary excretion of tricarboxylic acid (TCA) cycle intermediates. FAO transcripts and urinary nicotinamide and TCA cycle metabolites were moderately to strongly correlated with improvements in glomerular and proximal tubular injury. Weight loss plus pharmacological PPARα agonism is a promising means of attenuating DKD.
Interactions Between Breathy and Rough Voice Qualities and Their Contributions to Overall Dysphonia Severity
Authors: Park Yeonggwang , Anand Supraja , Kopf Lisa M. , Shrivastav Rahul , Eddins David A. 
Published: October 2022

Purpose:
Dysphonic voices typically present multiple voice quality dimensions. This study investigated potential interactions between perceived breathiness and roughness and their contributions to overall dysphonia severity.

Method:
Synthetic stimuli based on four talkers were created to systematically map out potential interactions. For each talker, a stimulus matrix composed of 49 stimuli (seven breathiness steps × seven roughness steps) was created by varying aspiration noise and open quotient to manipulate breathiness and superimposing amplitude modulation of varying depths to simulate roughness. One-dimensional matching (1DMA) and magnitude estimation (1DME) tasks were used to measure perceived breathiness, roughness, their potential interactions, and overall dysphonia severity. Additional 1DME tasks were used to assess a set of natural stimuli that varied along both breathiness and roughness.

Results:
For the synthetic stimuli, the 1DMA task indicated little interaction between the two voice qualities. For the 1DME task, breathiness magnitude was influenced by roughness step to a greater extent than roughness magnitude was influenced by breathiness step. The additive contributions of breathiness and roughness to overall severity gradually diminished with increasing breathiness and roughness steps, possibly reflecting a ceiling effect in the 1DME task. For the natural stimuli, little consistent interaction was observed between breathiness and roughness.

Conclusions:
The matching task revealed minimal interaction between perceived breathiness and roughness, whereas the magnitude estimation task revealed some interaction between the two qualities and their cumulative contributions to overall dysphonia severity. Task differences are discussed in terms of differences in response bias and the role of perceptual anchors.

Supplemental Material:

https://doi.org/10.23641/asha.21313701
Optimization of Manufacturing Processes by Reducing the Costs of Tools and Equipment on Hydraulically Operated High-Pressure Technological Lines
Authors: Popescu Teodor Costinel , Chiriţă Alexandru-Polifron , Popescu Ana-Maria Carla , Vlad Andrei , Trăneci Gheorghe Alexandru , Popescu Alina Iolanda 
Published: October 2022

Most technological manufacturing lines include hydraulically operated stationary tools, devices and equipment. During a manufacturing cycle, there are phases, usually short, in which part of the hydraulic cylinders of the drive systems concerned, with small gauges and displacement speeds, have to generate / maintain high clamping or pressing forces, which implies functioning at high working pressures.
The solution for such cylinders is to use modular hydraulic pumping units comprising: oil tank; low-pressure electric pump; hydraulic directional valve for starting, stopping and changing the direction of displacement of the cylinder; electric pump pressure control valve; pressure filter; return filter; oscillating hydraulic pressure intensifier (minibooster mounted directly on the cylinder).
Such pumping units, which consume low pressure (in the primary side of the minibooster) to generate high pressure (in the secondary side of the minibooster), are cost-effective when it comes to the procurement of components, installing them, the space required for installation, and their maintenance, too.
The classic applications of using them are for achieving and maintaining high pressure values, either in volumes of closed spaces (endurance tests on pipes and tanks), or at the active stroke end of hydraulic cylinders (hydraulic presses).
The authors demonstrate, on a laboratory test bench, the following:
- The range of applications of such pumping units can be extended in a third direction, namely for actuation of hydraulic cylinders with low gauge / speeds and constant high load (high working pressure) over the entire stroke;
- The uniformity of displacement of these cylinders with load over the entire stroke, fed and actuated by such pumping units, is weakly affected by the pulsating mode of operation of the hydraulic pressure intensifier.
Motorized spiral enteroscopy-assisted ERCP in surgically altered anatomy: early experience from a retrospective cohort study
Authors: Schneider Markus , Höllerich Jörg , Gerges Christian , Balasus Nicole , Neuhaus Horst , Beyna Torsten 
Published: October 2022

Background Motorized spiral enteroscopy (MSE) was recently introduced into clinical practice. The aim of the current study was to evaluate the feasibility and safety of MSE for biliopancreatic interventions in patients with surgically altered anatomy.
Methods Patients with surgically altered anatomy receiving MSE-assisted ERCP at a single, endoscopy referral center were retrospectively enrolled between January 2016 and June 2021.
Results 36 patients (14 female, 22 male), median age 67 years (range 43–88), with biliary (n = 35) and pancreatic (n = 1) indications for MSE-ERCP, were enrolled. The majority (75.0 %) had relevant comorbidities (American Society of Anesthesiologists class III). Surgical reconstruction included Roux-en-Y (n = 30) and Billroth II (n = 6). Technical success rates for enteroscopy, cannulation, and interventions were 86.1 %, 83.9 %, and 100 %, respectively. The overall MSE-ERCP success rate was 72.2 %. One major complication occurred (2.8 %; delayed post-sphincterotomy bleeding).
Conclusions This is the first study to demonstrate the feasibility and safety of MSE-assisted ERCP in postsurgical patients with altered anatomy at an expert center. These data justify further evaluation of this new technique, preferably in a prospective multicenter trial.
Documentation Burden in Nursing and Its Role in Clinician Burnout Syndrome
Authors: Gesner Emily , Dykes Patricia C. , Zhang Lingling , Gazarian Priscilla 
Published: October 2022

Abstract
Objectives The purpose of this study is to understand the relationship between documentation burden and clinician burnout syndrome in nurses working in direct patient care. The Office of the National Coordinator considers documentation burden a high priority problem. However, the presence of documentation burden in nurses working in direct patient care is not well known. Furthermore, the presence of documentation burden has not been linked to the development of clinician burnout syndrome.
Methods This paper reports that the results of a cross-sectional survey study comprised of three tools: (1) The burden of documentation for nurses and mid-wives survey, (2) the system usability scale, and (3) Maslach's burnout inventory for medical professionals.
Results Documentation burden has a weak to moderate correlation to clinician burnout syndrome. Furthermore, poor usability of the electronic health record (EHR) is also associated with documentation burden and clinician burnout syndrome.
Conclusion This study suggests that there is a relationship between documentation burden and clinician burnout syndrome. The correlation of poor usability and domains of clinician burnout syndrome implies the need for more work on improving the usability of EHR for nursing documentation. Further study regarding the presence of documentation burden and its correlation to clinician burnout syndrome should focus on specific areas of nursing to understand the drivers of documentation burden variation within and across specialty domains.
Phase equilibria molecular simulations of hydrogen hydrates via the direct phase coexistence approach
Authors: Michalis Vasileios K. , Economou Ioannis G. , Stubos Athanasios K. , Tsimpanogiannis Ioannis N. 
Published: October 2022

We report the three-phase (hydrate–liquid water–vapor) equilibrium conditions of the hydrogen–water binary system calculated with molecular dynamics simulations via the direct phase coexistence approach. A significant improvement of ∼10.5 K is obtained in the current study, over earlier simulation attempts, by using a combination of modifications related to the hydrogen model that include (i) hydrogen Lennard-Jones parameters that are a function of temperature and (ii) the water–guest energy interaction parameters optimized further by using the Lorentz–Berthelot combining rules, based on an improved description of the solubility of hydrogen in water.
Assassins and apples: the environmental constraints of two snails that threaten Australian aquatic systems
Authors: Bodley Brenton , Holmes Bonnie J. , Williams Samuel M. , Tibbetts Ian R. , Burfeind Dana D. , McDougall Carmel 
Published: October 2022

Context Alien freshwater snails pose a substantial risk to Australian native aquatic biota. Aims This study aims to determine the thermal and salinity ranges of two introduced species within Australia, Pomacea sp. and Anentome sp., to facilitate predictions of their potential geographic range should they become widely established. Methods Laboratory tests were conducted to assess behavioural responses of snails to altered temperature or salinity after different acclimation regimes. Key results After acclimation at 25°C, Pomacea sp. had a median activity range of 13.5–38°C and Anentome sp. of 12–38.5°C. Higher acclimation temperatures produced observable effects, whereas lower acclimation temperatures did not. Salinity tolerances differed, with Pomacea sp. remaining active at up to 8 parts per thousand (ppt) (after acclimation at 25°C), with acclimation at 20°C resulting in a lower salinity tolerance. By contrast, Anentome sp. snails were active at up to 5 ppt after low salinity acclimation, demonstrating enhanced salinity tolerance compared with non-salinity acclimations. Conclusions These results showed that both snails are capable of surviving temperatures and salinities that would allow invasion into subtropical and warm-temperate Australian aquatic systems. Implications Free from the constraints of natural predators, competitors, and parasites, these snails should be of great concern to biosecurity agencies in Australia.
Food security and livelihood challenges of extensive goat production systems in desertification areas
Authors: Ronda-Borzone Pablo , Donoso Guillermo , Riveros F. José Luis 
Published: October 2022

Abstract

Undernourishment and food insecurity are still challenges threatening poor urban and rural communities. Approximately 12% of the global population faced severe food insecurity in 2020, representing 928 million people. A significant fraction of the world’s land surface is covered by drylands, and this proportion is expected to increase in the future, affecting the food security and livelihood of 2 billion people due to climate change. Goats have traditionally been a significant asset and source of protein for rural communities inhabiting arid and semiarid regions of the world. We hypothesize that goats were intentionally selected by communities in dry environments and might be the optimal animal to breed in the future due to their capability to survive in dry environments and to utilize less water than other livestock production systems. However, it must be considered that only a small fraction (1%–2%) of the total water consumed by goats is drunk or utilized directly by the animals. Most of the water consumed is utilized to grow the feed that livestock such as goats consumes. Which in most regions of the world is green water due to goats feed on the vegetation that grows in rainfed rangelands. Increasing water efficiency in goat production is thus critical in the context of increasing water scarcity and desertification. However, there is little research on goat water productivity and the impact of decreasing water security on the sustainability of goat production and, hence, on the livelihoods in small communities in developing countries. Therefore, the impact

of increasing water scarcity and desertification on goat production in rainfed lands should be a research priority.
Perturbations of a class of locally rotationally symmetric cosmologies with applications to dissipative fluids
Authors: Semrén Philip , Bradley Michael 
Published: October 2022

Abstract
A gauge invariant perturbation theory, based on the

1
+
1
+
2

covariant split of spacetime, is used to study first order perturbations on a class of anisotropic cosmological backgrounds. The perturbations as well as the energy-momentum tensor are kept general, giving a system of equations on which different physical situations may be imposed. Through a harmonic decomposition, the system is then transformed to evolution equations in time and algebraic constraints. This result is then applied to dissipative one-component fluids, and on using the simplified acausal Eckart theory the system is reduced to two closed subsystems, governed by four and eight harmonic coefficients for the odd and even sectors respectively. The system is also seen to close in a simplified causal theory. It is then demonstrated, within the Eckart theory, how vorticity can be generated from viscosity.