bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ECONOMIA POLÍTICA DA TRANSFORMAÇÃO DO NORDESTE: de Furtado a Unger
Authors: Sávio Teixeira Carlos 
Published: August 2022

70 Teixeira

Este artigo analisa duas propostas de
reorganização
estrutural da sociedade nordestina, elaboradas em momentos distintos,
uma sob a liderança intelectual de Celso Furtado e a outra
de
Mangabeira Unger. Argumenta que ambas partem da premissa de que o
enfrentamento dos graves problemas da região mais desigual
do
país requer ousada reconstrução
institucional,
assim como a adoção de políticas
públicas
que objetivem enfrentar os constrangimentos estruturais da
região e não apenas amenizá-los.
Sustenta que a
proposta que deu origem à SUDENE, capitaneada por Furtado,
serviu de inspiração para a segunda empreitada
mais
recente, sendo as duas iniciativas baseadas em ideias que ultrapassam
uma perspectiva meramente redistributivista.

PALAVRAS-CHAVE: Nordeste. Mudança estrutural.
Reconstrução institucional. Celso Furtado.
Mangabeira
Unger.

THE
POLITICAL ECONOMY OF THE
TRANSFORMATION OF THE NORTHEAST: from Furtado to Unger
Carlos Sávio Teixeira

This paper analyzes two proposals of structural reorganization of
northeastern society, prepared at different moments in time, one under
Celso Furtado’s intellectual leadership and the other under
Mangabeira Unger’s leadership. It argues that both stem from
the
premise that the fight against the serious problems faced by the
country’s most unequal region requires bold institutional
reconstruction, as well as the adoption
of public policies that confront the structural constraints of the
region, rather than just lessen them. It reinforces the idea that the
project that gave origin to SUDENE (Superintendence for the Development
of the Northeast), headed by Furtado, served as inspiration to the
second latest venture, since the two initiatives were based on ideas
that surpass a merely redistributivist perspective.

KEY WORDS: Northeast, structural change, institutional reconstruction,
Celso Furtado, Mangabeira Unger.

L’ÉCONOMIE
POLITIQUE DE
LA TRANSFORMATION DU NORD-EST: de Furtado à Unger
Carlos Sávio Teixeira

Cet article analyse deux propositions de réorganisation
structurelle de la société du nordest
élaborées à des moments
différents,
l’une sous le leadership intellectuel de Celso Furtado et
l’autre de Mangabeira Unger. On y argumente que toutes deux
partent de la prémisse selon laquelle les affrontement des
graves problèmes de la région la plus
inégalitaire
du pays suppose une reconstruction institutionnelle courageuse ainsi
que l’adoption de politiques publiques prêtes
à
affronter les contraintes structurelles de la région et non
pas
seulement les atténuer. On y affirme que la proposition qui
a
donné naissance à la SUDENE, menée par
Furtado, a
servi d’inspiration à une deuxième
entreprise plus
récente, ces deux initiatives étant
fondées sur
des idées allant audelà d’une
perspective purement
distributive.

MOTS-CLÉS: Nord-est, changement structurel, reconstruction
institutionnelle, Celso Furtado, Mangabeira Unger.

Publicação
Online
do Caderno CRH no Scielo: http://www.scielo.br/ccrh

Publicação
Online
do Caderno CRH: http://www.cadernocrh.ufba.br
POLÍTICA HABITACIONAL E LOCAÇÃO SOCIAL EM SALVADOR
Authors: Baltrusis Nelson , Nazem Mourad Laila 
Published: August 2022

Este artigo tem como objetivo analisar o mercado imobiliário de locação em Salvador. Num primeiro momento, caracterizaremos o problema habitacional em Salvador, para o que nos apoiaremos nas diretrizes e ações previstas no Plano Municipal de Habitação de Interesse Social (PMHIS). Em seguida, trataremos das políticas implantadas pelos governos do estado e federal, destacando a experiência do Programa de Arrendamento Residencial (PAR) e incorporando algumas considerações sobre o Programa Minha Casa, Minha Vida. Também será abordada a questão do mercado de locação em Salvador a partir do perfil de moradores e da dinâmica do mercado. PALAVRAS-CHAVE: Aluguel social. Política de habitação. Instrumentos de planeamento urbano. HOUSING POLICY AND SOCIAL RENT IN SALVADOR, BRAZIL Nelson Baltrusis Laila Nazem Mourad This article seeks to analyze the real state rental market in Salvador, Brazil. Initially, we describe the housing problem in Salvador based on the guidelines and actions foreseen in the Municipal Plan for Social Interest Housing (PMHIS). Then we treat the policies implemented by state and federal administrations, emphasizing the experience of Social Leasehold Housing (PAR), and including a few considerations on My Home, My Life program. We also approach the issue of the rental market in Salvador based on the profile of dwellers and on the dynamics of the market. KEYWORDS: Social rent. Housing policy. Urban planning instruments. POLITIQUE DE L’HABITAT ET LOGEMENTS SOCIAUX À SALVADOR Nelson Baltrusis Laila Nazem Mourad L’objectif de cet article est d’analyser le marché de l’immobilier destiné à la location à Salvador. Dans un premier temps, et pour caractériser le problème du logement à Salvador, nous nous basons sur les directives et les actions prévues par le Plan Municipal des Logements Sociaux (PMHIS). Nous abordons ensuite les politiques mises en place par le gouvernement fédéral, mettons en évidence l’expérience du Programme de Bail Résidentiel (PAR) et nous y ajoutons quelques considérations concernant le Programme “Ma Maison, Ma Vie”. La question du marché locatif à Salvador est également traitée à partir du profil des habitants et de la dynamique du marché. MOTS-CLÉS: Location sociale. Politique de l’Habitat. Instruments de planification urbaine. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
Genome‐Wide 3′‐UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk‐Associated Functional Loci at 8p21.2 in Chinese Population
Authors: Zhang Ning , Huang Da , Jiang Guangliang , Chen Siteng , Ruan Xiaohao , Chen Haitao , Huang Jingyi , Liu Ao , Zhang Wenhui , Lin Xiaoling , Wu Yishuo , Zhang Qin , Li Jing , Tsu James Hok‐Leung , Wei Gong‐Hong , Na Rong 
Published: August 2022

AbstractMicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at the three prime untranslated regions (3′‐UTRs) of mRNAs and play critical roles in the etiology of cancers. Single nucleotide polymorphisms (SNPs) in the 3′‐UTR miRNA‐binding regions may influence the miRNA affinity. However, this biological mechanism in prostate cancer (PCa) remains unclear. Here, a three‐stage genome‐wide association study of 3′‐UTR SNPs (n=33 117) is performed in 5515 Chinese men. Three genome‐wide significant variants are discovered at 8p21.2 (rs1567669, rs4872176, and rs4872177), which are all located in a linkage disequilibrium region of the NKX3‐1 gene. Phenome‐wide association analysis using the FinnGen data reveals a specific association of rs1567669 with PCa over 2,264 disease endpoints. Expression quantitative trait locus analyses based on both Chinese PCa cohort and the GTEx database show that risk alleles of these SNPs are significantly associated with low expression of NKX3‐1. Based on the MirSNP database, dual‐luciferase reporter assays show that risk alleles of these SNPs downregulate the expression of NKX3‐1 via increased miRNA binding. These results indicate that the SNPs at the 3′‐UTR of NKX3‐1 significantly downregulate NKX3‐1 expression by influencing the affinity of miRNA and increase the PCa risk.
Optimum Differentiation of Frontotemporal Lobar Degeneration from Alzheimer Disease Achieved with Cross‐Sectional Tau Positron Emission Tomography
Authors: Josephs Keith A. , Tosakulwong Nirubol , Gatto Rodolfo G. , Weigand Stephen D. , Ali Farwa , Botha Hugo , Graff‐Radford Jonathan , Machulda Mary M. , Savica Rodolfo , Schwarz Christopher G. , Senjem Matthew L. , Boeve Bradley F. , Kantarci Kejal , Jones David T. , Ramanan Vijay K. , Fields Julie A. , Reichard Ross R. , Dickson Dennis W. , Petersen Ronald C. , Jack Clifford R. , Lowe Val J. , Whitwell Jennifer L. 
Published: August 2022

ObjectiveThis study was undertaken to assess cross‐sectional and longitudinal [18F]‐flortaucipir positron emission tomography (PET) uptake in pathologically confirmed frontotemporal lobar degeneration (FTLD) and to compare FTLD to cases with high and low levels of Alzheimer disease (AD) neuropathologic changes (ADNC).MethodsOne hundred forty‐three participants who had completed at least one flortaucipir PET and had autopsy‐confirmed FTLD (n = 52) or high (n = 58) or low ADNC (n = 33) based on Braak neurofibrillary tangle stages 0–IV versus V–VI were included. Flortaucipir standard uptake value ratios (SUVRs) were calculated for 9 regions of interest (ROIs): an FTLD meta‐ROI, midbrain, globus pallidum, an AD meta‐ROI, entorhinal, inferior temporal, orbitofrontal, precentral, and medial parietal. Linear mixed effects models were used to compare mean baseline SUVRs and annual rate of change in SUVR by group. Sensitivity and specificity to distinguish FTLD from high and low ADNC were calculated.ResultsBaseline uptake in the FTLD meta‐ROI, midbrain, and globus pallidus was greater in FTLD than high and low ADNC. No region showed a greater rate of flortaucipir accumulation in FTLD. Baseline uptake in the AD‐related regions and orbitofrontal and precentral cortices was greater in high ADNC, and all showed greater rates of accumulation compared to FTLD. Baseline differences were superior to longitudinal rates in differentiating FTLD from high and low ADNC. A simple baseline metric of midbrain/inferior temporal ratio of flortaucipir uptake provided good to excellent differentiation between FTLD and high and low ADNC (sensitivities/specificities = 94%/95% and 71%/70%).InterpretationThere are cross‐sectional and longitudinal differences in flortaucipir uptake between FTLD and high and low ADNC. However, optimum differentiation between FTLD and ADNC was achieved with baseline uptake rather than longitudinal rates. ANN NEUROL 2022;92:1016–1029
P and Cu Dual Sites on Graphitic Carbon Nitride for Photocatalytic CO2Reduction to Hydrocarbon Fuels with High C2H6Evolution
Authors: Wang Gang , Chen Zhe , Wang Tao , Wang Dingsheng , Mao Junjie 
Published: August 2022

AbstractThe light‐driven CO2reduction to multi‐carbon products is especially meaningful, while the low efficiency of multi‐electron transfer and sluggish C−C coupling greatly hinder its development. Herein, we report a photocatalyst comprising of P and Cu dual sites anchored on graphitic carbon nitride (P/Cu SAs@CN), which achieves a high C2H6evolution rate of 616.6 μmol g−1 h−1in reducing CO2to hydrocarbons. The detailed spectroscopic characterizations identify the formation of charge‐enriched Cu sites, where the isolated P atoms serve as hole capture sites during photocatalysis. Theoretical simulations combined with in situ FTIR measurement reveal a kinetically feasible process for the formation of C−C coupling intermediate (*OC−COH) and confirm the favorable production of C2H6on the P/Cu SAs@CN photocatalyst. This work offers new insights into the photocatalyst design with atomic precision toward highly efficient photocatalytic CO2conversion to high value‐added carbon products.
Highly Efficient Electrosynthesis of Nitric Oxide for Biomedical Applications
Authors: Jin Jing , Mao Junjie , Wu Wenjie , Jiang Ying , Ma Wenjie , Yu Ping , Mao Lanqun 
Published: August 2022

AbstractNitric oxide (NO) constitutes one of the most versatile therapeutics for biomedical applications. The efficient and on‐demand NO generation essentially dictates its concentration dependent therapeutic activity. Here, we report an electrochemical system employing a rationally designed single‐iron atom based biomimetic catalyst (i.e., Fe SAC), for high‐efficient and controlled NO generation. The Fe SAC shows superior catalytic ability in electrochemical reduction of nitrite, with maximal NO generation rate achieving 2.1 μM (min μg)−1. Theoretical studies suggest the significant decrease of Gibbs‐free energy of NO2−adsorption on single‐iron atom accounts for its high catalytic efficiency. Moreover, ample amount of NO can be controllably generated in a potential dependent manner. For antibacterial application, the generated NO overwhelmingly disrupts both gram‐negative and gram‐positive strains, highlighting a great promise to expedite NO research in both basic and applied sciences.
Spectroscopic studies of 7,8‐diacetoxy‐4‐methylcoumarin and 7,8‐dipentynoyl‐4‐methylcoumarin binding with calreticulin
Authors: Moss Patrice E. , Talanova Galina G. , Fang Yayin , Thomas Courtney 
Published: August 2022

AbstractCalreticulin (CRT) is a protein found mainly in the endoplasmic reticulum (ER) that maintains calcium levels and controls protein folding, but has recently been found at the cell surface, cytoplasm, and in the extracellular matrix. CRT participates in multiple physiological processes such as gene expression, the immune response, and cancer. Calreticulin has been shown to autoacetylate with the binding of preferred ligand 7,8‐diacetoxy‐4‐methylcoumarin (DAMC). This project aims to develop a chemical biology approach to investigate importance of CRT acylating abilities on its nonendoplasmic reticulum functions by targeting the downstream substrates of CRT acetylation. Our goal was to use CRT to transfer a pentynoyl tag (using a novel ligand, DPeMC) to its substrates, which can then be used as a handle for protein identification.Molecular modelling using available data in the literature was used to approximate the binding interface between CRT and the acylation ligands. Molecular Operating Environment (MOE) software was used to perform sequence alignment, simulated annealing, positional refinement, and blind docking of acylated coumarins with the CRT model. Docking studies pointed to the P domain as the most thermodynamically and sterically favourable region for acylated coumarin binding with tryptophan residue 200 within the active site on CRT. Absorption and fluorescence spectra of all coumarin compounds in ethanol:PBS (1:9 v/v) solution were investigated. Stern–Volmer quenching constant (KSV), binding constant (K), and number of binding sites (n) of each coumarin compound with CRT was determined. Our studies demonstrated that acyl coumarin compounds bind to CRT using a dynamic quenching mechanism, bind to a single binding site on the P domain, and that the protein–ligand interaction is spontaneous and exothermic.
A network analysis of self‐reported psychoneurological symptoms in patients with head and neck cancer undergoing intensity‐modulated radiotherapy
Authors: Lin Yufen , Bruner Deborah W. , Paul Sudeshna , Miller Andrew H. , Saba Nabil F. , Higgins Kristin A. , Shin Dong M. , Zhang Wenhui , Miaskowski Christine , Xiao Canhua 
Published: August 2022

BackgroundPatients with head and neck cancer experience psychoneurological symptoms (PNS) (i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity‐modulated radiotherapy (IMRT) that decrease their functional status, quality of life, and survival rates. The purpose of this study was to examine and visualize the relationships among PNS within networks over time and evaluate for demographic and clinical characteristics associated with symptom networks.MethodsA total of 172 patients (mean age, 59.8 ± 9.9 years; 73.8%, male; 79.4%, White) completed symptom questionnaires four times, namely, before IMRT (T1), 1 month (T2), 3 months (T3), and 12 months (T4) post IMRT. Network analysis was used to examine the symptom‐symptom relationships among PNS. Centrality indices, including strength, closeness, and betweenness, were used to describe the degrees of symptom network interconnections. Network comparison test was used to assess the differences between two symptom networks.ResultsDepression was associated with the other four symptoms, and fatigue was associated with the other three symptoms across the four assessments. Based on the centrality indices, depression (rstrength = 1.3–1.4, rcloseness = 0.06–0.08, rbetweeness = 4–10) was the core symptom in all symptom networks, followed by fatigue. Female gender, higher levels of stress, and no alcohol use were associated with stronger symptom networks in network global strength before IMRT.ConclusionNetwork analysis provides a novel approach to gain insights into the relationships among self‐reported PNS and identify the core symptoms and associated characteristics. Clinicians may use this information to develop symptom management interventions that target core symptoms and interconnections within a network.Lay summary

This study describes the symptom–symptom relationships for five common symptoms in patients with head and neck cancer receiving radiotherapy.

Depression and fatigue appeared to be two core symptoms that were connected with sleep disturbance, pain, and cognitive dysfunction within a network.

Several characteristics (i.e., female, higher stress, no alcohol use) were associated with stronger symptom networks.
Structural analysis of regional transcatheter aortic valve underexpansion and its implications for subclinical leaflet thrombosis
Authors: Qiu Dong , Azadani Ali N. 
Published: August 2022

AbstractSubclinical leaflet thrombosis has been increasingly recognized following transcatheter aortic valve replacement (TAVR). Determining the risk factors is vital in preventing clinical leaflet thrombosis and ensuring long‐term value durability. Clinical data have indicated that regional stent under‐expansion of transcatheter aortic valves (TAVs), particularly self‐expanding devices, may be associated with an increased risk of subclinical leaflet thrombosis. This study aimed to determine the effects of regional TAV frame under‐expansion on leaflet kinematics, leaflet structural characteristics, and explore its impact on the likelihood of leaflet thrombosis. In this study, mild and moderate regional frame under‐expansion of a 26‐mm CoreValve were examined using experimental testing and computational simulations. The results indicated that regional TAV frame under‐expansion impairs leaflet kinematics and reduces the range of motion in leaflets with an angle less than 120°. The reduced range of motion can increase blood stasis on the surface of the TAV leaflets. The results also demonstrated that regional frame under‐expansion induced localized high‐stress regions in the leaflets close to the fixed boundary edge. The increased mechanical stress can lead to accelerated tissue degeneration. The study improves our understanding of the effects of regional stent under‐expansion in TAVR. Post‐procedural balloon dilatation of self‐expanding TAVs can potentially be advantageous in reducing leaflet distortion and normalizing leaflet stress distribution. Large‐scale, prospective, and well‐controlled studies are needed to further investigate regional TAV frame under‐expansion effects on subclinical leaflet thrombosis and long‐term valve durability.
Bidirectional converter based on boost/buck DC‐DC converter for microgrids energy storage systems interface
Authors: Nimitti Fabiano Gonzales , Andrade António Manuel Santos Spencer 
Published: August 2022

SummaryIn this paper, a new bidirectional nonisolated DC‐DC (direct current–direct current) converter to interface microgrid energy storage systems is proposed. This converter is based on the classical bidirectional boost/buck converter, the most used converter in microgrids and can operate both in step‐down and step‐up modes. Besides that, this converter presents low number of components, low voltage and current stress on components, simplicity of operation, low current ripple from low‐side power supply, and two different modes of operation: synchronous and asynchronous. In addition, in this paper, the modeling, control, and power losses estimate of the proposed converter are carried out and the performance of the converter in different aspects of the microgrid application is evaluated, such as step load, abrupt power flux change, and transient analysis. A prototype of 1 kW, 144 to 400 V, is developed in the laboratory to validate the theoretical evaluations of the proposed converter. Besides that, the proposed converter is also evaluated under different dynamic condition which illustrates the effectiveness of the converter. Finally, the maximum efficiency obtained is 97.1% for 500 W working in step‐down operation.
Pyridine‐2(1H)‐thione as a Bifunctional Nucleophile in Reaction with PdII and PtII Aryl Isocyanide Complexes
Authors: Popov Roman A. , Mikherdov Alexander S. , Boyarskiy Vadim P. 
Published: August 2022

AbstractA method for obtaining C,S‐cyclometalated deprotonated diaminocarbene complexes via the addition of a bifunctional N,S‐nucleophile's endocyclic nitrogen atom to a coordinated isocyanide has been extended to the reactions with pyridine‐2(1H)‐thione. The coupling of PdII‐ and PtII‐bis(arylisocyanide) complexes with pyridine‐2(1H)‐thione leads to the formation of mononuclear C,S‐cyclometalated deprotonated diaminocarbene complexes in 90–96 % yield. The reaction proceeds via the initial coordination of the thione sulfur atom to the metal center followed by the intramolecular nucleophilic addition of the heterocyclic nitrogen atom to the metal‐ligated isocyanide carbon. Using an excess of pyridine‐2(1H)‐thione in this reaction leads to the formation of a mono‐C,S‐cyclometalated complex with a pendant mercaptopyridine ligand which is involved in the reversible intramolecular nucleophilic addition of the pyridine nitrogen to the isocyano carbon. The obtained complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies, and single‐crystal X‐ray diffraction.
Mechanistic Insights into Lewis Acid‐Controlled Torquoselective Nazarov Cyclization of Activated Dienones Bearing a Chiral Sulfoxide
Authors: Grenet Erwann , Robidas Raphaël , van der Lee Arie , Legault Claude Y. , Salom‐Roig Xavier J. 
Published: August 2022

AbstractThis work provides a switchable strategy to access, through a Nazarov cyclization, two diastereomeric disubstituted 3,4,5,6‐tetrahydrocyclopenta[b]pyran‐7(2H)‐ones from an activated dienone bearing a chiral sulfoxide. The switch in the torquoselectivity is controlled by the nature of the Lewis acid used as promoter. From the four possible stereoisomers, only the two trans were observed. The Lewis acids employed were achiral and the diastereoselectivities were dictated by the sulfinyl auxiliary. Density functional theory investigations shed light on the reaction mechanism. The experimental torquoselectivities were very closely reproduced and their inversion could be linked back to a change in the binding mode of the substrate.
Lewis Acid‐Catalyzed (3+2) Cycloaddition of 2‐Indolylmethanols with β,γ‐Unsaturated α‐Ketoesters
Authors: Yang Shuang , Wang Hai‐Qing , Gao Jun‐Nan , Tan Wen‐Xin , Zhang Yu‐Chen , Shi Feng 
Published: August 2022

AbstractA Lewis acid‐catalyzed (3+2) cycloaddition of 2‐indolylmethanols with β,γ‐unsaturated α‐ketoesters was established, which afforded a series of cyclopenta[b]indoles in overall high yields (up to 98 %) with excellent diastereoselectivities (up to >95 : 5 dr). This reaction not only represents the first C3‐nucleophilic (3+2) cycloaddition of 2‐indolylmethanols, but also provides a good example for (2+n) cycloaddition of β,γ‐unsaturated α‐ketoesters, which will add new contents to the chemistry of 2‐indolylmethanols. In addition, this approach provides an atom‐economic and useful method for the construction of biologically important cyclopenta[b]indole scaffold.