bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pour une approche nouvelle de la conception de dispositifs pour le suivi de maladies chroniques
Authors: CATOIR-BRISSON Marie-Julie , WREMBEL Elisa , RICCIO Pierre-Michel 
Published: July 2022

À partir d’une réflexion sur le concept de dispositif, notre article invite à s’interroger sur certaines approches de la conception et à analyser leur mise en œuvre concrète dans le champ de la santé et du bien-être, à travers deux exemples d’objets connectés (Fitbit et Apple Watch). Constatant d’abord que certains dispositifs de santé mobile ne sont pas adaptés aux utilisateurs, nous présentons ensuite le programme de recherche Som’Health, centré sur les troubles chroniques du sommeil, que nous menons depuis 2016. Sur la base de ce travail de terrain, nous proposons une approche nouvelle de la conception de dispositifs en santé mobile pour le suivi des maladies chroniques, en nous appuyant sur deux modèles théoriques : la théorie de l’utilisation et l’éthique de la conception.
Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to IFN Types I, II, and III
Authors: Constant David A , Van Winkle Jacob A , VanderHoek Eden , Dekker Simone E , Sofia M Anthony , Regner Emilie , Modiano Nir , Tsikitis V Liana , Nice Timothy J 
Published: July 2022

Abstract
The three types of IFN have roles in antimicrobial immunity and inflammation that must be properly balanced to maintain tissue homeostasis. For example, IFNs are elevated in the context of inflammatory bowel disease and may synergize with inflammatory cytokines such as TNF-α to promote tissue damage. Prior studies suggest that in mouse intestinal epithelial cells (IECs), type III IFNs are preferentially produced during viral infections and are less cytotoxic than type I IFN. In this study, we generated human IEC organoid lines from biopsies of ileum, ascending colon, and sigmoid colon of three healthy subjects to establish the baseline responses of normal human IECs to types I, II, and III IFN. We found that all IFN types elicited responses that were qualitatively consistent across intestinal biopsy sites. However, IFN types differed in magnitude of STAT1 phosphorylation and identity of genes in their downstream transcriptional programs. Specifically, there was a core transcriptional module shared by IFN types, but types I and II IFN stimulated unique transcriptional modules beyond this core gene signature. The transcriptional modules of type I and II IFN included proapoptotic genes, and expression of these genes correlated with potentiation of TNF-α cytotoxicity. These data define the response profiles of healthy human IEC organoids across IFN types, and they suggest that cytotoxic effects mediated by TNF-α in inflamed tissues may be amplified by a simultaneous high-magnitude IFN response.
Clinical Mental Health Measures and Prediction of Postconcussion Musculoskeletal Injury
Authors: Buckley Thomas A. , Bryk Kelsey N. , Enrique Alexander L. , Kaminski Thomas W. , Hunzinger Katherine J. , Oldham Jessie R. 
Published: July 2022

ContextThe rate of lower extremity musculoskeletal injury (LE MSK) is elevated after concussion; however, the underlying mechanism has not been elucidated. Physical characteristics have been investigated despite poorer mental health being a common postconcussion complaint and linked to MSKs.ObjectiveTo evaluate the role of mental health as a predictor of postconcussion LE MSK.DesignCase-control study.SettingIntercollegiate athletic training facility.Patients or Other ParticipantsA total of 67 National Collegiate Athletic Association Division I student-athletes (n = 39 females) who had been diagnosed with a sport-related concussion.Main Outcome Measure(s)The Brief Symptom Inventory-18, Hospital Anxiety and Depression Scale, and Satisfaction With Life Scale (SWLS) measures were completed at baseline (preseason) and on the day participants were cleared for unrestricted return to play (RTP) after a concussion. Two binary logistic regressions were used to predict postconcussion LE MSK within a year, one for the baseline time point and the second for the RTP time point. A 2 (group: LE MSK, no LE MSK)-by-2 (time: baseline, RTP) repeated-measures analysis of variance compared performance between baseline and RTP.ResultsSubsequent LE MSKs were sustained by 44 participants (65.7%). The only significant predictor of postconcussion LE MSK was the SWLS score at RTP, with Exp(B) = 0.64, indicating that an increased (improved) SWLS score was associated with a lower LE MSK rate. No significant interactions were present between mental health measures and subsequent MSK (P values = .105–.885).ConclusionsLimited associations were evident between postconcussion LE MSK and scores on commonly used measures of anxiety, depression, and satisfaction with life. Reported increased satisfaction with life was associated with a decreased injury risk, which warrants further attention. Our results suggest that these measures of anxiety, depression, and satisfaction with life have limited value in assisting sports medicine clinicians with determining which student-athletes are at elevated risk of postconcussion LE MSK.
Left Ventricular Chordae Tendinae Myxoma Causing Stroke
Authors: Suraci Nicholas , Lee Rebecca 
Published: July 2022

ABSTRACT
A 52-year-old woman presented with dysarthria and right-sided weakness in her upper and lower extremities prompting thrombolytic therapy with mild resolution of symptoms. Further work-up revealed (the source) a left ventricular myxoma on the chordae tendinae of the posterior medial papillary muscle, confirmed with transesophageal echocardiography and pathology. Herein, we present a rare case of embolic stroke from a myxoma originating on the chordae tendinae. To the best of our knowledge, the literature on the location and presentation of this tumor as seen in our patient is sparse in contemporary findings.
Therapeutic Effect of Tocilizumab on Inhibiting Cytokine Release Syndrome in Severe Coronavirus Disease 2019 Patients
Authors: Xu Lengnan , Liu Xin , Zhou Yangwei , Liu Aihua , Xu Xiaomao , Wang Xiaoxia , Zhong Xuefeng , Qiao Yu , Wen Li , Xi Huan , Mao Yonghui 
Published: July 2022

Abstract

Background and Objectives:
Older adults are more susceptible to coronavirus disease 2019 (COVID-19). Interleukin-6 (IL-6) is an important cytokine in the cytokine release syndrome (CRS), and tocilizumab blocks the IL-6 receptor. The objective is to analyze the effect of tocilizumab on CRS in older patients with severe COVID-19.

Materials and Methods:
Between February 10 and March 21, 2020, a total of 19 patients aged ≥60 years with severe or critical COVID-19 met the study inclusion criteria at the Tongji Hospital in Wuhan City, Hubei Province, China. The patients were divided into two groups: the tocilizumab group, with IL-6 levels, which exceeded the upper limit of normal by >10-fold and non-tocilizumab group.

Results:
Patients in the tocilizumab group were older (73.20 ± 4.44 vs. 66.21 ± 5.06 years, P = 0.014), had lower lymphocyte counts (0.71 ± 0.18 vs. 1.18 ± 0.59 × 109/L, P = 0.016), and higher high-sensitivity C-reactive protein (hsCRP) levels (94.04 ± 57.24 vs. 51.65 ± 45.37 mg/L, P = 0.035). Increases in ferritin (FER) and hsCRP levels in patients in the tocilizumab group were marked. Except for one patient who died, IL-6, FER, hsCRP levels, and the neutrophil/lymphocyte ratio in the remaining four patients decreased following treatment with tocilizumab. Tocilizumab did not cause any serious adverse reactions. There were no differences in mortality, days until lung computerized tomography improvement, or renal function between the two groups. The total mortality rate was 10.53%.

Conclusions:
Our results support the therapeutic efficacy and safety of tocilizumab in older patients with severe COVID-19.
Genomic Sequencing of Dengue Virus Strains Associated with Papua New Guinean Outbreaks in 2016 Reveals Endemic Circulation of DENV-1 and DENV-2
Authors: Jonduo Marinjho , Neave Matthew J. , Javati Sarah , Abala Dorothy , Bilo Eric , Kini Anthony , Kumbu Janlyn , Laman Moses , Robinson Leanne J. , Makita Leo , Susapu Melinda , Pomat William , Abdad Mohammad Yazid , Williams David T. , Horwood Paul F. 
Published: July 2022

ABSTRACT.
Over the past decade, the Pacific region has experienced many arboviral outbreaks, including dengue, chikungunya, and Zika viruses. Papua New Guinea (PNG) has a high burden of arboviral diseases, but there is a paucity of knowledge about the epidemiology and circulation of these viruses in the country. In this study, we report investigations into suspected arboviral outbreaks of febrile disease in PNG from December 2015 to June 2017. DENV-1 and DENV-2 were the mostly commonly detected viruses, and low circulation of DENV-3 and ZIKV was also detected. DENV-4 and CHIKV were not detected during this period. Full genome sequencing of selected positive samples revealed that circulation was dominated by endemic indigenous strains belonging to DENV-1 (genotype IV) and DENV-2 (genotype C) that have been present in the country for up to a decade. A DENV-2 sublineage was also identified that has been associated with outbreaks of severe dengue in both PNG and the Solomon Islands.
Evaluation of Strongyloides Awareness and Knowledge among Canadian Physicians Caring for Patients At Risk for Severe Strongyloidiasis: A National Cross-sectional Survey
Authors: De l’Étoile-Morel Samuel , Naeem Faheel , Alghounaim Mohammad , Semret Makeda , Yansouni Cedric P. , Libman Michael D. , Barkati Sapha 
Published: July 2022

ABSTRACT.
In Canada, a substantial proportion of migrants come from strongyloidiasis-endemic regions. Systematic screening for Strongyloides is not performed in immunocompromised patients in whom this infection could be potentially fatal. We aim to assess the level of Strongyloides awareness and knowledge among Canadian physicians caring for immunocompromised patients and identify factors currently associated with screening. Using an online survey distributed through Canadian medical associations, we collected information on physicians’ demographics, practice setting, overall awareness and knowledge of Strongyloides, and current practices. Descriptive analysis and logistic regression models were performed to identify the factors associated with Strongyloides screening. Nineteen national and provincial medical associations agreed to participate. Between November 2020 and August 2021, 368 of 5,194 (7%) physicians that were contacted responded to our survey. Quebec (46%) and Ontario (24%) were the most responsive. Sixty-nine percent of respondents practiced medicine in academic settings. Infectious disease (ID) specialists/medical microbiologists (38%) followed by nephrologists (33%) were the most represented. Most respondents (95%) had heard about Strongyloides. However, 36% of non-ID specialists considered themselves unfamiliar. Forty percent of respondents did not or rarely performed screening for strongyloidiasis in high-risk populations. Screening was associated with younger-aged physicians (odds ratio [OR] 2.35; 95% confidence interval [CI] 1.07–5.18), physicians who frequently served migrants (OR 3.33; 95% CI 1.44–7.66), or those who had training in global health and ID/medical microbiology (OR 3.71; 95% CI 1.21–11.34 and OR 46.42; 95% CI 15.89–135.59, respectively). Our survey suggests a general lack of knowledge of Strongyloides among Canadian physicians that is associated with low rates of screening in high-risk populations.
FACTORES SIGNIFICATIVOS QUE FACILITAN LA ENSEÑANZA DEL IDIOMA
Authors: Viteri-Guevara Xavier Oswaldo , Delgado-Vera Nathaly Estefanía , Tapia-Álvarez Cesar Vicente , Ortiz-Chimbo Karla Soledad 
Published: July 2022

La enseñanza de un idioma ha sido una temática relevante a través del tiempo pero su abordaje rara vez ha sido tratado con visión multidisciplinaria; sin embargo, atendiendo la importancia de manejar adecuadamente un idioma o más idiomas. Como objetivo esta investigación se planteó caracterizar, desde una revisión teórica, los factores significativos que influyen en la enseñanza de un idioma. Investigación que metodológicamente responde al paradigma positivista, con un enfoque cuantitativo de tipo documental, nivel descriptivo. Como técnica de recolección de datos se empleó la revisión documental, los instrumentos fueron el fichaje y el cuaderno de notas, siendo el análisis de contenido la técnica de análisis utilizada. Entre los factores significantes que influyen en la enseñanza de un idioma este estudio reveló: motivación de todos los actores involucrados en el proceso, profesores comprometidos con el proceso educativo, un docente que se apropia de las nuevas tendencias educativa para la enseñanza de los idiomas, aunado a estudiantes activos y participativos comprometidos con su propio aprendizaje y finalmente, una curricular ajustada a los tiempos actuales que desde el empleo de herramientas de apoyo diseñadas en función de los objetivo de enseñanza acordados, emplea las modalidades de software y plataformas educativas contextualizadas que permita el logro de las competencias adecuadas para hablar, comprender en forma oral, leer y escribir un idioma desde una perspectiva biopsicosocial.
Quality of the municipal service and satisfaction of the citizens of Piura 2021
Authors: Caballero Marreros Edson Johan , Choquehuanca Saldarriaga Carlos Alberto , Gonzales Agama Sara H. , Valenzuela Muñoz Alberto 
Published: July 2022

The objective of the research has been to determine the relationship between the quality of the municipal service and the satisfaction of the citizens of Piura 2021.
To meet this objective, we collected data using the survey technique and, as an instrument, the questionnaire, which we applied to a random sample of 384 citizens.
Once the data was collected, we created a database using SPSS Version 25, from which we described the variables (descriptive statistics) and the corresponding hypothesis tests (inferential statistics).
The main conclusion we have reached, with the investigation, has been that there is a significant relationship between the quality of the municipal service and the satisfaction of the citizens of Piura 2021.
Sustainable development trend of Vietnam’s energy industry and orientations for sustainable development of Vietnam oil and gas group until 2030 with vision to 2045
Authors: Hoàng Quốc Vượng 
Published: July 2022

Energy plays an important role in the socio-economic development of countries in general and particularly in the context that Vietnam is a dynamic economy with a high growth rate. In order to achieve the goals of sustainable economic development, the Government of Vietnam is determined to implement and accelerate structural transformation of the energy sector towards a greener, cleaner and more efficient use of energy.
As a national oil and gas company making large contribution to the country’s socio-economic development and at the same time a pillar in ensuring the national energy security, in view of the direct impacts of the energy transition trend, the Vietnam Oil and Gas Group is responsible for joining hands with the Government to ensure energy security, reduce greenhouse gas emissions to protect the environment and adapt to climate change, thus contributing to successfully implementing the sustainable development strategy.
PELATIHAN PEMBUATAN ALAT PENGASAP IKAN BAGI MASYARAKAT DI DESA KAKI AIR
Authors: Susiati Susiati , Umasugi Samsia , Bula Muhammad , Iye Risman 
Published: July 2022

Tujuan pengabdian kepada masyarakat ini adalah memberikan pelatihan pembuatan alat pengasap ikan kepada masyarakat Desa Kaki Air. Metode dalam pengabdian ini menggunakan pendekatan PAR (Participatory Action Research), yakni pelatihan berupa edukasi berbasis teori dan praktik terkait pelatihan pembuatan alat pengasap ikan kepada masyarakat Desa Kaki Air yang meliputi dua tahapan, yakni tahap pendampingan teori dan tahap pendampingan praktik. Sasaran pelaksanaan kegiatan pengabdian ini adalah masyarakat Desa Kaki Air, Kecamatan Kaeyeli, Kabupaten Buru. Peserta pelatihan berjumlah 20 orang.
Adapun hasil pelaksanaan kegiatan pengabdian ini, yakni tahap persiapan, yaitu tim pengabdi melakukan observasi awal, yakni tim pengabdi ke lokasi untuk melihat, mendeteksi, serta menganalisis situasi atau masalah yang dihadapi oleh masyarakat desa Kaki Air. Setelah tim pengabdi mengidentifikasi masalah, selanjutnya tim menetapkan pendekatan yang cocok untuk diaplikasikan dalam kegiatan pengabdian ini; tahap pendampingan teori, yakni tim pengabdi memberikan materi-materi terkait pengolahan ikan dan pengasapan ikan. Dalam pemberian materi ini, tim menggunakan metode ceramah, presentasi, diskusi, dan tanya jawab. Peserta sangat antusias mengikuti dan mendengarkan penjelasan para pemateri. Hal tesebut terlihat saat diskusi, peserta banyak memberikan pertanyaan, gagasan atau ide terkait wujud alat pengasapan yang akan dipraktikkan; tahap pendampingan praktik, yakni tim beserta peserta pelatihan membuat secara langsung alat pengasap ikan dengan mengacu pada konsep-konsep yang telah disepakati saat tahap pendampingan teori. Hasil karya tim sangat diapresiasi oleh peserta serta para perangkat desa Kaki Air.
Alternatif dan Mekanisme Pengobatan Penyakit yang Disebabkan Topeule pada Etnis Kaili Rai di Desa Silanga
Authors: Hendra Hendra , Helnanur Helnanur 
Published: July 2022

Metode pengobatan berkembang sesuai dengan dunia pemikiran dan kebudayaan manusia. Masa awal metode pengobatan tradisional sangat dipengaruhi oleh kepercayaan terhadap dunia nonmaterial. Periode pengobatan modern mengeliminasi kepercayaan itu dan lebih menawarkan pemahaman tentang kesehatan yang bisa diterima logika. Metode pengobatan tradisional tidak sepenuhnya hilang di masa modern ini. Eksistensinya masih bisa ditemukan di tengah-tengah masyarakat pedesaan yang pemikiranya terekontruksi dan terisolasi oleh kepercayaan tradisional. Pemikiran mengenai hal yang berkenaan dengan kesehatan dan penyakit yang berasal dari ilmu gaib ini yang kemudian menjadi tolak ukur bagi mereka untuk memilih pengobatan dengan ilmu gaib pula dalam hal ini dukun. hal ini kemudian juga menjadi permasalahan besar yang dihadi oleh masyarakat di Desa Silanga dimana akibat adanya kepercayaan mengenai ilmu gaib hitam yang dimiliki oleh manusia untuk menyakiti manusia yang lain yang dalam Bahasa Etnik Kaili Rai mereka sebut sebagai topeule. Kemudian melatar belakangi masyarakat memilih dukun (sando) dalam proses pengobatan penyakitnya. Hasilnya dari penelitian ini menunjukan bahwasanya praktik-praktik pengobatan supranatural masih hidup di tengah-tengah masyarakat Desa Silanga dan masih dipercayai oleh masyarakat penggunanya.
Women in Sustainable Education: Glass Ceiling among Female Schools Principals in Indonesia
Authors: Juwitasari Reni 
Published: July 2022

Sex segregation remains happening in the education realm. In the 21st century, Indonesian women's participation in the public sphere still becomes an issue, especially leadership. Women are perceived as the second class of society, even obtaining the negative stereotype of incapable leaders, which the myth of leadership belongs to men's world. Like an oxymoron, women are "freely binding," meaning they can be involved in the public sphere. However, they are encountering "glass-ceiling" to be in the top position, especially in rural West Java, where women have been perceived for their physical appearance-minded rather than the capability of leadership. The proposition of women principals in compulsory education in Indonesia is underrepresented compared to men principals with 38.68 percent and 61.32 percent. Women are capable of good leader who has leveraged their subordinates through positive relationships, empowering others, and improving schools. Therefore, women empowerment is essential to achieving sustainable education under SDG Priority 4 Quality of Education and SDG Priority 5 Gender Equality. This study aims to analyze the presence of women school principals' "status quo" and "glass-ceiling" in Indonesia by utilizing the PAR gender model of Blaikie et al. (2003), consisting of three factors; root causes, dynamic pressures, and unsafe condition. Hence, this study will be able to offer policy recommendations on women's leadership empowerment. This research used the exploratory approach by investigating sixteen school principals of elementary education and literature reviews, such as research reports and academic articles related to women leaders in education. This study found that Indonesian women in the educational realm have dealt with the glass ceiling deriving from root causes on power and structure. Meanwhile, dynamic pressures are knowledge dissemination and the unsafe condition on economic imbalances and discrimination on welfare and social protection, which becomes a sustainable threat and negatively affects the 2030 Agenda for Sustainable Development.
Testing dynamic balance in youth female volleyball players: development, reliability and usefulness
Authors: Dolo Karla , Grgantov Zoran , Jelaska Igor 
Published: July 2022

Purpose.The aim of this research was to develop a dynamic balance test and examine its reliability by comparing first trial results with the average and best ones from multiple attempts.Methods.Overall, 32 volleyball players (aged 11.3 ± 0.67 years) were investigated in 2 sessions (with a 14-day interval), each consisting of 3 trials of the modified bench walk with 3 turns (MBW3T) test. Three test methods were compared: first trial (MBW3T<sub>trial1</sub>), average result (MBW3T<sub>mean</sub>), and best result (MBW3T<sub>best</sub>). A paired-sample <i>t</i>-test determined differences with an effect size. Test-retest reliability was assessed with an intraclass correlation coefficient.Results.The paired-sample <i>t</i>-test revealed no significant difference in performance between test and retest for MBW3T<sub>trial1</sub> (<i>t</i> = 0.01, <i>p</i> = 0.99), MBW3T<sub>mean</sub> (<i>t</i> = –0.46, <i>p</i> = 0.65), and MBW3T<sub>best</sub> (<i>t</i> = –1.05, <i>p</i> = 0.30). Standard error of measurement (SEM) as the absolute reliability within-individual variation parameter showed that MBW3T<sub>trial1</sub> had higher variation than MBW3T<sub>mean</sub> and MBW3T<sub>best</sub>, in which the measurement error was minimal. To identify usefulness, we calculated the smallest worthwhile change and compared it with SEM for different effect sizes; the test was rated marginal to satisfactory. The study results indicated fair reliability when the first trial was observed and good reliability for the mean and best of 3 trials.Conclusions.MBW3T<sub>mean</sub> and MBW3T<sub>best</sub> are cheap, simple, reliable, and marginal to satisfactory useful measures for assessing dynamic balance in youth female volleyball players and can be used in scientific and practical settings.