bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lateritic soil geopolymer composites for ceramics and engineering construction applications
Authors: Sá Ribeiro Marilene G. , Sardela Mauro R. , Keane Patrick F. , Lopez Juan S. , Kriven Waltraud M. , Sá Ribeiro Ruy A. 
Published: March 2022

AbstractCharacterization of an Amazonian, laterite‐doped, kaolinitic soil (LK) or “lateritic soil” and laterite‐doped metakaolin (LMK) calcined at two distinct rates, as well as granite‐marble (GM) particulate industrial wastes was performed by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), X‐ray diffraction (XRD), energy dispersive X‐ray fluorescence (XRF) spectrometry, and particle size and distribution analysis. In addition, an LMK geopolymer (GP) and a lateritic metakaolin‐based GP reinforced with granite‐marble composite (LMKGP‐GM) were tested for water resistance and for mechanical strength. XRD and XRF were used to investigate the composition of the composite materials, while XRD confirmed the formation of GP. Just as in the case of highly reactive commercial metakaolin used in construction, according to this study, lateritic soil‐based metakaolin presented similar characteristics. Therefore, it could be used in the development of more sustainable ceramics and construction materials, including the use of GM waste as a reinforcing phase/aggregate.
Experimental analysis and machine learning modeling of optical properties of lithium disilicate glass–ceramics comprising lithium tantalate as a secondary phase
Authors: DeCeanne Anthony V. , Wilkinson Collin J. , Dittmer Marc , Ritzberger Christian , Rampf Markus , Mauro John C. 
Published: March 2022

AbstractColor is an important property of lithium disilicate (LD) glass–ceramics for a variety of applications. For example, the color of dental glass–ceramics needs to be tuned to match the color of natural teeth. The present study examines the optical properties of LD glass–ceramics containing lithium tantalate as a secondary phase via ultraviolet–visible spectroscopy. A large data set is analyzed to investigate the relationship between heat treatments and optical properties, specifically the L*a*b* color coordinates. The color coordinates are dependent on the heat treatment following previously acquired phase data. The data are used to train a two‐step machine learning model to predict what heat treatment is needed to obtain a given set of color coordinates.
Diagnosis and treatment of influenza based on health insurance claims between the 2010–2011 and 2019–2020 influenza seasons in Japan
Authors: Shimizu Eiko , Iwasaki Kosuke , Hongo Yoshie , Yoshida Manami , Kinoshita Masahiro , Hiroi Shinzo , Tamura Daisuke 
Published: March 2022

AbstractMedical practices for influenza virus infection vary among countries. In Japan, treatment with anti‐influenza drugs is recommended for patients diagnosed with influenza. This health claims database study provides quantitative information aimed at describing the actual medical practices, including diagnostic testing and medication use, for managing influenza in Japan. Most patients diagnosed with influenza underwent diagnostic tests and were prescribed anti‐influenza drugs. Meanwhile, the majority of patients prescribed anti‐influenza drugs had undergone diagnostic testing. However, an increase in the percentage of anti‐influenza prescriptions without diagnostic testing was observed during the 2019–2020 influenza season, which may be associated with the COVID‐19 pandemic.
Animal feed contains diverse populations of Salmonella
Authors: Shariat Nikki W. , Larsen Bryan R. , Schaeffer Chery , Richardson Kurt E. 
Published: March 2022

AbstractAimsIn food animals, Salmonella can exist as multiserovar populations, and the goal of this study was to determine whether Salmonella-positive animal feed samples also consist of multiserovar populations.Methods and ResultsIn all, 50 Salmonella-positive samples, collected from 10 countries, were cultured using three different media for Salmonella isolation: universal pre-enrichment broth, Rappaport-Vassiliadis (RV) broth and tetrathionate (TT) broth. The samples included 25 samples from feed ingredients, 13 from complete feed and 12 feed mill dust samples. Samples from pelleted overnight cultures were analysed by CRISPR-SeroSeq to examine serovar populations in individual samples. Serovars Anatum and Mbandaka were the most commonly identified and were found in feed, feed ingredients and feed environments. Serovars commonly associated with human illness were also identified, and included serovars Enteritidis, Typhimurium and Infantis. Overall, we detected 12 different serogroups (37 different serovars), with eight serovars belonging to the O:7 serogroup (C1). Over half (56%) of the samples contained two or more serovars, with 11 serovars found in one sample. Feed ingredients exhibited higher serovar diversity, with an average of three serovars. Across paired samples of pre-enriched and enriched populations, the Bray–Curtis dissimilarity metric showed that 83% of serovar populations were a strong match.ConclusionsThe data presented show that serovars belonging to the O:7 serogroup are commonly found in feed, and that feed can contain multiple serovars. The serovar populations across different Salmonella media were largely concordant.Significance and Impact of StudyThe presence of Salmonella in animal feed is considered a transmission route into meat and poultry products and this study demonstrates that animal feed can contain multiple Salmonella serovars.
Methicillin-resistant Staphylococcus aureus contamination of high-touched surfaces in a university campus
Authors: Ababneh Qutaiba , Jaradat Ziad , Khanfar Malak , Alnohoud Rahaf , Alzu'bi Mallak , Makahleh Sara , Abulaila Sally 
Published: March 2022

Abstract

Aim
Methicillin-resistant Staphylococcus (MRSA) is a public and occupational health concern, both in community and healthcare settings. In recent years, community-acquired MRSA (CA-MRSA) has emerged as a major causative agent of infections in individuals with no health care exposure or any of the classical risk factors associated with infections. Environmental surfaces frequently touched by hands play a role in the transmission of CA-MRSA, where inanimate objects are considered potential reservoirs and the source of MRSA infections. The purpose of this study was to examine the prevalence of MRSA on environmental surfaces inside a university campus.

Methods and Results
A total of 1078 high-touch surface samples were collected from door handles, light switches, desks, keyboards and restroom surfaces. MRSA isolates were identified and confirmed by PCR, utilizing the Staph. aureus nuc and mecA genes. Antibiotic resistance profiles were determined using disc diffusion and minimum inhibitory concertation methods. In addition, the ability to form biofilms was investigated by the 96-well plate microdilution technique. PCR assays were performed to detect enterotoxin and antibiotic-resistant genes. The genetic diversity of MRSA was determined through multi-locus sequence typing (MLST), spa and agr typing methods. The overall contamination of Staph. aureus and MRSA was 14.6% (157/1078) and 2.8% (30/1078), respectively. The highest rate of MRSA contamination was detected in restroom sinks and door handles. All MRSA isolates were MDR, with the highest resistance observed was against trimethoprim-sulfamethoxazole. Most MRSA isolates (29/30, 97%) carried at least one gene encoding for staphylococcal enterotoxins (SE), with 10 different SE genotypes were observed. A total of 16 different spa types were detected among the 30 MRSA isolates. Multi-locus sequence typing revealed that 21 MRSA isolates belonged to eight known sequence types (ST), while nine isolates were novel strains. The most detected ST and spa types were ST22 and t223, respectively. Agr types I and III were represented in 28 out of the 30 isolates. The majority of the isolates carried SCCmec type IV, but only one isolate was positive for PVL.

Conclusions
Our findings signify the potential of the high-touch surfaces in harbouring and transmitting MRSA to campus staff and students. Thus, the implementation of effective prevention measures outside the healthcare setting is needed to reduce the risk of acquiring CA-MRSA infections.

Significance and Impact
MRSA infections impose a profound economic burden due to illness and productivity loss. The results of this study not only help us to better understand the environmental reservoirs of this pathogen, but also provide information about its transmission pathways and healthcare settings entry routs.
Long‐term efficacy and safety of brodalumab in moderate‐to‐severe plaque psoriasis: a post hoc pooled analysis of AMAGINE‐2 and ‐3
Authors: Reich K. , Iversen L. , Puig L. , Lambert J. , Mrowietz U. , Kaplan Saday K. , Warren R.B. 
Published: March 2022

AbstractBackgroundBrodalumab is a monoclonal antibody that blocks multiple interleukin (IL)‐17 family cytokines by binding to the shared A subunit of the IL‐17 receptor. In Phase 3 trials, brodalumab provided high levels of skin clearance through 52 weeks in patients with moderate‐to‐severe psoriasis and was generally well tolerated.ObjectivesTo assess efficacy response rates and safety outcomes through 120 weeks for patients with moderate‐to‐severe psoriasis who received brodalumab.MethodsSafety and efficacy data were pooled for patients from AMAGINE‐2 and −3 who received continuous brodalumab 210 mg every 2 weeks, or brodalumab 210 mg every 2 weeks after receiving either brodalumab 140 mg or placebo through Week 12. Efficacy data are presented using observed data, non‐responder imputation (NRI) and a combination of NRI and missing at random assumption to account for missing data. Absolute PASI scores are presented using mixed‐effect model repeated measure modelling and multiple imputation.ResultsBased on observed data at Week 120, 86% of the continuous brodalumab 210 mg group achieved PASI 90 and 74% achieved PASI 100. At Week 12, 58% of this group achieved absolute PASI ≤1; this proportion increased to approximately 80% at Week 52 and persisted through Week 120. Among patients receiving continuous brodalumab 210 mg, median duration of brodalumab exposure was 747 days and the overall exposure‐adjusted event rate of treatment emergent adverse events per 100 patient‐years was 329. Safety through 120 weeks was comparable to the results of the primary AMAGINE‐2 and −3 studies. Patients who switched to brodalumab 210 mg after receiving either brodalumab 140 mg or placebo through Week 12 showed similar skin clearance and safety profiles.ConclusionsBrodalumab treatment was well tolerated and resulted in high levels of skin clearance that were rapidly achieved and maintained through Week 120, supporting its long‐term efficacy and safety profile.
Influence of manufacturing technique on the color of zirconia restorations: Monolithic versus layered crowns
Authors: Manziuc Manuela Maria , Gasparik Cristina , Burde Alexandru Victor , Ruiz‐López Javier , Buduru Smaranda , Dudea Diana 
Published: March 2022

AbstractObjectivesThe study aimed to compare the color of monolithic and layered zirconia crowns fabricated using different brands in the cervical, middle, and incisal areas.Materials and MethodsA total of 45 crowns were fabricated from three brands (Katana, Nacera, Cercon) using three methods (monolithic = ML (n=5), cut‐back + enamel = BL (n=5), cut‐back + dentin + enamel = TL (n=5)). CIE L*, a* b*, C*, h° color coordinates were recorded with a dental spectrophotometer in cervical, middle, and incisal areas. Color differences between manufacturing techniques, tooth areas, and brands were calculated using the CIEDE2000(1:1:1) formula, and the values were compared to the perceptibility (PT00) and acceptability thresholds (AT00). Comparisons between color coordinates were analyzed statistically (Kruskal‐Wallis and Mann‐Whitney U tests, p < 0.001).ResultsSignificant differences were found between CIE L*, a*, b*, C*, h° coordinates of the zirconia crowns (p < 0.001), generally. The lowest color differences were obtained between BL and TL crowns in cervical and middle areas. Color differences between cervical and middle areas were mostly below PT00. An acceptable color difference was found between Katana and Cercon crowns.ConclusionsThe manufacturing technique and the brand influenced the color of zirconia crowns. Also, the color of the crowns varied from cervical to incisal.Clinical SignificanceReproducing the optical properties of teeth with ceramic crowns might be challenging, given the differences in the internal configuration of the enamel and dentine, as well as their complex behavior when interacting with light. When deciding whether to fabricate a monolithic crown in translucent zirconia or improve its appearance by layering with more translucent glass–ceramic, the clinicians and dental technicians must be aware of these procedures' effect on the final color of the restorations.
Molecular cloning, expressional analyses and functional identification of TRAIL in tilapia, Oreochromis niloticus
Authors: Yi Liyuan , Sun Caiyun , Wu Jinying , Hou Zengxin , Li Wensheng 
Published: March 2022

AbstractThe tumour necrosis factor superfamily (TNFSF) plays critical roles in tumour apoptosis, tissue morphogenesis and lineage determination. TNFSF10 (TRAIL or Apol‐2) belongs to the tumour necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumour cell lines upon binding to death‐inducing signalling receptors. In this study, we identified TNFSF10 from Nile tilapia (Oreochromis niloticus) and found it was most closely related to Japanese pufferfish (Takifugu rubripes) TNFSF10. Amino acid identity between tilapia TNFSF10 and mandarin fish (Siniperca chuatsi) TRAIL was 69.2%. The highest expression of TNFSF10 mRNA was observed in the liver. In vitro studies showed that the mRNA expression of TNFSF10 was significantly stimulated by LPS in head kidney leucocytes, but remarkably inhibited by Poly I:C in spleen leucocytes. In vivo studies showed Streptococcus agalactiae infection significantly induced the mRNA expression of TNFSF10 in both the head kidney and spleen. The soluble recombinant protein Trx‐TNFSF10 could induce cytotoxicity and apoptosis in HeLa cells with cycloheximide as a promoter. Taken together, these results in this study indicate that TNFSF10 may play important roles in the immune system of Nile tilapia.
Development of eco‐industrial parks in Ethiopia: The case of Hawassa Industrial Park
Authors: Negesa Doryn , Cong Wei , Cheng Lei , Shi Lei 
Published: March 2022

AbstractAs win‐win solutions at the park level, eco‐industrial parks (EIPs) have become the mainstream model to realize a sustainable transition of industrial parks in the world. However, few cases have been implemented in Africa, even though Africa is fertile ground for the growth of industrial parks. This study explores the transition process and outcome of a typical African industrial park—Hawassa Industrial Park (HIP) in Ethiopia. We adopted the international framework for EIPs and applied the strategic niche management (SNM) framework to uncover the transition performance and process. This study shows that HIP's development is a clear articulation of implementing the sustainable development strategy and the industrial park development corporation's role. However, the analysis also identified limitations such as the impracticability of certain framework criteria and inapplicable indicators. Although HIP is still at the nascent stages of EIP implementation, we have found three critical factors for EIP development in Ethiopia from our preliminary observation. These include the importance of actors, the learning process, and having standards for an indicator system. These indicators are of exceptional value to Ethiopian researchers and practitioners in integrating sustainability into local economic development.
Application of high‐frequency ultrasound in detection and identification of nasal filling injection materials
Authors: Chai Hongli , Su Xueshang , Yuan Li , Li Zehui , Liu Yue , Dou Maomei , Hu Jintian 
Published: March 2022

AbstractObjectiveTo access and determine the ultrasound images of different nasal filling injection materials.MethodsFrom November 2014 to November 2021, facial ultrasound images of Plastic Surgery Hospital of Chinese Academy of Medical Science were analyzed and judged.ResultsA total of 337 cases were enrolled, including 203 cases of hyaluronic acid, 102 cases of polyacrylamide hydrogel, 16 cases of calcium hydroxyapatite‐based fillers, 10 cases of silicone oil, and 6 cases of growth factor. According to ultrasound images, hyaluronic acid is characterized by anechoic area with a clear boundary, which seems like a capsule, and the internal echo is uniform, there is no obvious blood flow signal in it. It is possible to see a stratified appearance if hyaluronic acid diffused into surrounding tissues, and it is mainly exhibited as hypoechoic area, with anechoic or hypoechoic areas in it. Polyacrylamide hydrogel showed irregular flocculent hypoechoic or fine punctured hypoechoic under ultrasound, which could aggregate into cystic hypoechoic area or disperse in tissue space, and echo floating or dislocation flow could be seen under probe pressure. Under ultrasound, calcium hydroxyapatite‐based filler is characterized by heterogeneous hyperechoic or hypoechoic area, which spreads in the tissue space with unclear boundary with surrounding tissue, and no obvious liquid flow could be observed. Silicone oil is commonly found in the dermis, it is characterized by cloud‐like high echo, the deep tissue is not clear. Growth factor is characterized by heterogeneous echo, which is similar to the echo of peripheral tissue, and the boundary is not clear. Plenty of blood flow signals suggest infection. If the image is characterized with posterior echogenic shadow, it suggests calcification.ConclusionsHigh‐frequency ultrasound can identify the types of nasal filling injection materials and can guide the selection of clinical treatment plan according to the classification of imaging features.
Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Authors: Martin Emmanuel , Zhang Anson , Campiche Remo 
Published: March 2022

AbstractBackgroundScalp conditions such as flaky or oily scalp affect people across ethnicities and age groups. In addition to flaking, increased sebum secretion, itching, and compromised scalp barrier function were described. Scalp conditions are aesthetically disturbing and may cause psychological distress in affected individuals who are looking for mild and effective treatment at the same time. Saccharide isomerate has a long history as a skin moisturizer, and it was found to improve skin barrier function, also suggesting possible beneficial effects on scalp.AimsTo provide relevant claim substantiation to introduce saccharide isomerate as a new scalp care active against scalp flaking condition.Material and MethodsWe conducted a placebo‐controlled clinical study in an adult Chinese population affected by dandruff scalp as assessed by an adherent scalp flaking score. We monitored transepidermal water loss (TEWL), sebum secretion, and scalp flaking during 28 days.ResultsFormulations containing Saccharide isomerate significantly improved all parameters both over time as well as compared to the placebo formulation.ConclusionWe propose Saccharide isomerate for cosmetic formulations directed toward improving scalp conditions such as dandruff or oily scalp.
A prolonged period of low interest rates in Europe: Unintended consequences
Authors: Malovaná Simona , Bajzík Josef , Ehrenbergerová Dominika , Janků Jan 
Published: March 2022

AbstractWe examine the potential adverse effects of a prolonged period of low interest rates on financial stability from multiple perspectives. First, we provide a unique comparison of natural rates of interest estimated using two approaches—with and without financial factors—for six large European countries inside and outside the euro area. Second, we provide a comprehensive review of the empirical literature, allowing us to identify and categorize financial vulnerabilities, which may be created and fueled by low interest rates. Third, we discuss a situation in which a prolonged period of low interest rates may lead to a point of no return by contributing to higher indebtedness, overvalued asset prices and underpriced risks, resource and credit misallocation, and lower productivity. With respect to all of that, we offer a few monetary policy considerations. Specifically, we suggest that (i) monetary policy should act symmetrically over the medium to long term, (ii) both the short‐term and long‐term costs and benefits of pursuing accommodative or restrictive monetary policy should be accounted for, and (iii) monetary and macroprudential policies need to be coordinated, and their interactions should be accounted for in order to find the best policy mix for the economy.
Let’s Fix our Own Problem: Quelling the Irresponsible Research Perfect Storm
Authors: Aguinis Herman , Archibold Estelle E. , Rice Darryl B. 
Published: March 2022

AbstractWe invoke the metaphor of the perfect storm and argue that several factors have converged to create what we label the irresponsible research perfect storm. Many of these issues can be fixed by applying management theories, but we argue this has not been done due to the existence of a research‐research gap. Akin to the research‐practice gap, the research‐research gap is a disconnect between the research academics are producing and the research academics ourselves are using to manage our own business schools, journals, professional associations, and careers. Accordingly, we offer four sets of theory‐based recommendations to quell this storm and narrow the research‐research gap: (1) promote shared governance and accountability across stakeholder groups, (2) expand the definition of scholarly impact, (3) provide journal editors with relevant resources, and (4) strengthen the knowledge, skills, and abilities of current and future scholars.
Who is the individual that will complain about temporomandibular joint clicking?
Authors: Poluha Rodrigo Lorenzi , De la Torre Canales Giancarlo , Bonjardim Leonardo Rigoldi , Conti Paulo César Rodrigues 
Published: March 2022

AbstractBackgroundUnderstanding the profile of the individual complaining of TMJ clicking can help in the clinical approach of these patients.ObjectiveTo identify clinical variables associated with individuals who complain about and seek treatment for TMJ clicking.MethodsSeventy‐two individuals, composed the sample: Group 1 – patients with a complaint of TMJ clicking who sought treatment; (n = 36); Group 2 – individuals with TMJ clicking who have no complaints about it (n = 36). Three categories of data were evaluated: clinical (gender; age; side of TMJ clicking; TMJ pain; self‐reported level of bother; previous TMJ clicking information); somatosensory (mechanical pain threshold [MPT], wind‐up ratio [WUR], pressure pain threshold [PPT]); and, psychosocial (Pain Vigilance and Awareness Questionnaire [PVAQ]; Pain Catastrophising Scale [PCS]; Tampa Scale for Kinesiophobia for Temporomandibular Disorders [TSK/TMD]); The Perceived Stress Scale (PSS); The State‐Trait Anxiety Inventory (STAI).ResultsGroup 1 was composed mostly of female patients, with TMJ pain, without previous orientation about the condition, bothered by the clicking, with lower PPT and higher scores in the PVAQ, PCS, TKS/TMD, PSS and STAI scales than Group 2. The groups did not differ significantly for side of TMJ clicking, age, MPT and WUR.ConclusionIndividuals who have a TMJ clicking complaint and seek treatment are mostly female, have TMJ pain, have not received previous orientation about TMJ clicking, are bothered by the clicking, have a lower pain threshold and higher scores of hypervigilance, catastrophising, kinesiophobia, stress and anxiety than people with TMJ clicking who do not report it.