bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of pattern of ABO Blood groups in pediatric diabetic patients – An observational study
Authors: Javed Nimra , Yasin Shazia , Fatima Javeria , Khan Tehmina Nafees Sonia , Fateen Tooba , Saqlain Nazish , Farhan Saima 
Published: June 2022

Diabetes Mellitus (DM) is the most frequently occurring metabolic disorder, caused by inadequacy in secretion of insulin or malfunction leading to chronic hyperglycemia. Well-established corroborations have been reported in the literature suggesting association of ABO blood group with DM. The available literature focuses on adult population, with limited information of said association in children. Thus this study was aimed to determine the association of ABO blood group with Diabetes in pediatric patients having confirmed diagnosis. This was a comparative cross sectional study conducted from October 2021-January 2022 at Endocrinology Ward, Children Hospital Lahore (CHL), Pakistan. The study was approved by the local research ethics committee of CHL and conducted according to the declaration of Helsinki 2000. Blood grouping was done by forward and reverse methods. A total of 25 patients, including 18 males and 7 females were included. Frequency of blood group B (n=10;40%) was highest followed by blood group O (n=4;16%), A blood group (n=3;12%), and AB (n=1;4%) in males. In females, the blood group AB (n=3;12%) has the highest frequency followed by O (n=2;8%). Blood group A (n=1;4%) and B (n=1;4%) had the same frequency among female diabetic patients
Black Hole to Photosphere: 3D GRMHD Simulations of Collapsars Reveal Wobbling and Hybrid Composition Jets
Authors: Gottlieb Ore , Liska Matthew , Tchekhovskoy Alexander , Bromberg Omer , Lalakos Aretaios , Giannios Dimitrios , Mösta Philipp 
Published: June 2022

Abstract
Long-duration γ-ray bursts (GRBs) accompany the collapse of massive stars and carry information about the central engine. However, no 3D models have been able to follow these jets from their birth via black hole (BH) to the photosphere. We present the first such 3D general-relativity magnetohydrodynamic simulations, which span over six orders of magnitude in space and time. The collapsing stellar envelope forms an accretion disk, which drags inwardly the magnetic flux that accumulates around the BH, becomes dynamically important, and launches bipolar jets. The jets reach the photosphere at ∼1012 cm with an opening angle θ

j
∼ 6° and a Lorentz factor Γ
j
≲ 30, unbinding ≳90% of the star. We find that (i) the disk–jet system spontaneously develops misalignment relative to the BH rotational axis. As a result, the jet wobbles with an angle θ

t
∼ 12°, which can naturally explain quiescent times in GRB lightcurves. The effective opening angle for detection θ

j
+ θ

t
suggests that the intrinsic GRB rate is lower by an order of magnitude than standard estimates. This suggests that successful GRBs are rarer than currently thought and emerge in only ∼0.1% of supernovae Ib/c, implying that jets are either not launched or choked inside most supernova Ib/c progenitors. (ii) The magnetic energy in the jet decreases due to mixing with the star, resulting in jets with a hybrid composition of magnetic and thermal components at the photosphere, where ∼10% of the gas maintains magnetization σ ≳ 0.1. This indicates that both a photospheric component and reconnection may play a role in the prompt emission.
ALMA Images the Eccentric HD 53143 Debris Disk
Authors: MacGregor Meredith A. , Hurt Spencer A. , Stark Christopher C. , Howard Ward S. , Weinberger Alycia J. , Ren Bin , Schneider Glenn , Choquet Elodie , Mawet Dmitri 
Published: June 2022

Abstract
We present ALMA 1.3 mm observations of the HD 53143 debris disk—the first infrared or millimeter image produced of this ∼1 Gyr old solar analog. Previous HST STIS coronagraphic imaging did not detect flux along the minor axis of the disk, which could suggest a face-on geometry with two clumps of dust. These ALMA observations reveal a disk with a strikingly different structure. In order to fit models to the millimeter visibilities and constrain the uncertainties on the disk parameters, we adopt a Markov Chain Monte Carlo approach. This is the most eccentric debris disk observed to date with a forced eccentricity of 0.21 ± 0.02, nearly twice that of the Fomalhaut debris disk, and also displays an apocenter glow. Although this eccentric model fits the outer debris disk well, significant interior residuals remain, which may suggest a possible edge-on inner disk, which remains unresolved in these observations. Combined with the observed structure difference between HST and ALMA, these results suggest a potential previous scattering event or dynamical instability in this system. We also note that the stellar flux changes considerably over the course of our observations, suggesting flaring at millimeter wavelengths. Using simultaneous TESS observations, we determine the stellar rotation period to be 9.6 ± 0.1 days.
Finding Lensed Direct-collapse Black Holes and Supermassive Primordial Stars
Authors: Vikaeus Anton , Whalen Daniel J. , Zackrisson Erik 
Published: June 2022

Abstract
Direct-collapse black holes (DCBHs) may be the seeds of the first quasars, over 200 of which have now been detected at z > 6. The James Webb Space Telescope (JWST) could detect DCBHs in the near-infrared (NIR) at z ≲ 20 and probe the evolution of primordial quasars at their earliest stages, but only in narrow fields that may not capture many of them. Wide-field NIR surveys by Euclid and the Nancy Grace Roman Space Telescope (RST) would enclose far greater numbers of DCBHs but only directly detect them at z ≲ 6–8 because of their lower sensitivities. However, their large survey areas will cover thousands of galaxy clusters and massive galaxies that could gravitationally lens flux from DCBHs, boosting them above current Euclid and RST detection limits and revealing more of them than could otherwise be detected. Here, we estimate the minimum number density of strongly lensed DCBHs and supermassive primordial stars required for detection in surveys by Euclid, RST, and JWST at z ≲ 20. We find that for reasonable estimates of host halo numbers RST, Euclid, and JWST could potentially find hundreds of strongly lensed DCBHs at z = 7–20. RST would detect the most objects at z ≲ 10 and JWST would find the most at higher redshifts. Lensed supermassive primordial stars could potentially also be found, but in fewer numbers because of their short lifetimes.
Evaluation of clinical efficacy of topical tacrolimus 0.1% and clobetasol propionate 0.05% in desquamative gingivitis, manifestation of oral lichen planus
Authors: Kavlakova Lilia 
Published: June 2022

Abstract

Introduction: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disorder with unknown etiology. Numerous treatment options have been reported, with topical corticosteroids being very often used as the first-line therapy for gingival lesions. However, a relatively novel therapeutic option is provided by tacrolimus.
Aim: To compare the clinical effectiveness of topical tacrolimus 0.1% and clobetasol propionate 0.05% in the management of desquamative gingivitis, a distinct clinical manifestation of OLP.
Materials and methods: This comparative study included 20 patients with histologically proven symptomatic OLP with gingival manifestation. The participants were divided into 2 groups: group A (clobetasol propionate 0.05% cream) and group B (topical tacrolimus 0.1% ointment). They were instructed to apply topical medications twice daily for three consecutive weeks. Custom trays have been used for better drug delivery. The patients were recalled at 1, 2, and 3 months after cessation of therapy for a follow-up control of any relapse.
Results: The subjects in both groups showed a significant reduction in the burning sensation/pain and discomfort according to the visual analog scale (VAS). Similarly, both groups showed reduction in the efficiency index, and moderate improvement especially was seen in the tacrolimus 0.1% group (53%) and the clobetasol propionate group 0.05% (47%). Patients treated with clobetasol propionate 0.05% didn’t have a relapse at 2 and 3 months after cessation of treatment. In contrast, 30% of the patients treated with tacrolimus 0.1% had a relapse of the condition at 2 and 3 months.
Conclusions: Tacrolimus can be considered as a good alternative topical medication in the treatment of OLP, especially in those patients that do not respond to topical corticosteroids.
Pharmaceutical Care for Patients with Headache
Authors: Gavazova Evelina Z. , Grekova-Kafalova Daniela D. 
Published: June 2022

Introduction: Headache cephalalgia is the condition in which individuals feel pain in different parts of the head. It is one of the most common disorders believed to be amenable to self-treatment. The pharmacist can provide significant support to patients.Aim: The aim of this study was to present the role of pharmacists in the prevention of headaches.Materials and methods: We reviewed the available information in the biggest databases on the problem.Results: Drug therapy is only part of an effective approach to the management of headaches. In many cases headache triggers can be identified and lifestyle changes instituted that reduce the frequency of attacks. Rest, sleep, and adequate hydration are often important components of successful management regimes. Patient education and detailed information for their disease can play an active role in the treatment. The reviewed literature shows the importance of the involvement of community pharmacists of the treatment of headache disorders.As the most easily approachable healthcare providers pharmacists can assist patients in finding appropriate relief of headaches and ensure rational and safe headache treatment.Conclusions: Pharmacists have a crucial role in optimizing the results of the medical therapy.
EFFICACY OF MONOCLONAL ANTIBODIES ASSOCIATION IN PRESENCE OF TWO SARS-COV-2 DOMINANT VARIANT OF CONCERN. COMPARATIVE STUDY VERSUS MONOTHERAPY AGAINST A SINGLE VARIANT: A REAL EXPERIENCE IN UMBRIA, ITALY.
Authors: Schiaroli Elisabetta , De Socio Giuseppe Vittorio , Gidari Anna , Malincarne Lisa , Benedetti Sara , Lanzi Alessandra , Bastianelli Sabrina , Pierucci Sara , Busti Chiara , Francisci Daniela 
Published: June 2022

Background and Objective
In patients with mild-to-moderate COVID-19 and at high risk of progression, bamlanivimab as monotherapy was utilized in Italy until its revocation. Afterwards, the mAbs Bamlanivimab-Etesevimab or Casirivimab-Imdevimab were used, while Sars-Cov-2 delta variant emerged. Aim of our study was to compare demographic, clinical characteristics, hospitalization rate and 30 days symptoms of patients treated with these mAbs from April to November 2021 respect to patients with bamlanivimab alone.
Methods
A retrospective observational study was performed. Demographic and clinical characteristics before and after infusion were evaluated. Moreover, a telephone interview about 30 days after the infusion was carried out to evaluate the overall course. We compared the observed differences concerning comorbidities, vaccination status, and outcomes. between the two treated populations. Lastly, we evaluated the baseline neutralizing activity of sera from vaccinated patients against their their own virus isolate.
Results
A better efficacy of the mAbs combinations compared to monotherapy with regard to global hospitalization (6.5 % vs 20.5 %, p = 0.021) and 30 days symptoms (p<0.001). A not significant better trend for COVID19 and alpha variant pneumonia hospitalization (6.5% vs 10%, 4.25 % vs 10.25%) was shown. Infections in vaccinated patients mostly occurred in the absence of neutralizing antibodies. However, SARS-CoV-2 delta variants were isolated even in the presence of high specific neutralizing activity.
Conclusions
Our data are in line with other experiences drawn from real life but show a higher hospitalization risk than that observed in the randomized trials which were performed before the spread of VOCs
THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES
Authors: Orhan Bedrettin , Özkalemkaş Fahir , Özkocaman Vildan , Gürbüz Büşra , Ersal Tuba , Pınar İbrahim Ethem , Yalçın Cumali , Candar Ömer , Çubukçu Sinem , Güllü Koca Tuba , Ali Rıdvan 
Published: June 2022

Background and Objective: Perianal pathologies are the most common cause of perianal infections in patients with hematological malignancies. Perianal infection diagnosis in this group of patients is difficult, thus careful anorectal examination is necessary, with imaging modalities. The literature revealed a knowledge gap on the approach of anal pathologies in patients with neutropenia during diagnosis or chemotherapy. This study aimed to examine our institutional data of perianal complications and investigate the relationship among the white blood cell-neutrophil count, perianal lesion, and the type of treatment in patients with hematologic malignancies during the neutropenic period.
Methods: Patients with a hematologic malignancy, hospitalized for cytotoxic chemotherapy, complicated by perianal pathology, and documented by at least one imaging method were included in the study.
Results: A total of 42 patients were included in the study. The comparison between the groups revealed no statistical significance between the anal abscess formation and the neutrophil count and previous perianal pathology. A statistical significance in favor of acute myeloid leukemia was found between patient diagnosis and anal abscess development. An inverse relationship was found between the number of white blood cells at hospitalization and having an anal pathology operation. It was observed that patients with high white blood cell count were less operated on due to anal pathology.
Conclusions: In conclusion, this article has shown that white blood cell count at the time of hospitalization in patients with hematological malignancy, can affect the operation status of patients due to anal pathologies that may occur in the neutropenic period.
A pedagogia de Jesus no caminho de Emaús
Authors: De Paiva Helber Augusto , Machado Vianna Torres Marcela , Martins de Almeida Nogueira Sonia 
Published: June 2022

Este estudo tem como pedra angular a Páscoa de Jesus e se desenvolve partindo da narrativa de Lucas (24,13-35). Seu objeto de análise é o itinerário da fé pascal, construindo-se com o que é percebido como elementos da pedagogia de Jesus em seu magistério. Entendemos que o texto de Lucas se refere a três cenários: o caminho (vv. 13-28); a aldeia de Emaús (vv. 29-32) e Jerusalém (vv. 33-35) e trabalhamos com os fatos que neles se destacam, três fatos em que a iniciativa é de Jesus. Com este artigo pretendemos desenvolver uma aproximação do caminho percorrido pelos discípulos de Emaús e identificar os princípios fundamentais da pedagogia de Jesus, com o objetivo de compreender sua ação. Temos a proposta de dar ênfase ao caminho interior que se percorre neste relato de Lucas e que se faz palavra de anúncio, para que possamos escutar esse anúncio e empreender esse caminho. Fazemos duas perguntas: como reconheço Jesus no dia a dia e como buscar Jesus e ter um contato mais real com Ele.
ԿԱՏԱՐՈՒՄՆԵՐԸ ՄՏԱՎՈՐ ՍԵՓԱԿԱՆՈՒԹՅԱՆ ԻՐԱՎՈՒՆՔԻ ՀԱՄԱԿԱՐԳՈՒՄ
Authors: Այվազյան Մարիամ 
Published: June 2022

Հոդվածը նվիրված է մտավոր սեփականության իրավունքի համակարգում կատարումների դերի ուսումնասիրությանը: Տասնամյակներ շարունակ լայնորեն քննարկվում է այն հարցը, թե արդյոք կատարումները է պետք պաշտպանվեն հեղինակային իրավունքի, թե հարակից իրավունքների համակարգով: Այս հարցին պատասխանելու համար հոդվածում նախ քննարկվում են հեղինակային իրավունքի օբյեկտների պաշտպանության չափանիշները: Հոդվածում կատարված եզրակացությունը այն է, որ կատարումները ունեն բոլոր անհրաժեշտ հատկանիշները հեղինակային իրավունքով պաշտպանության համար: Սակայն նախընտրելի է պահպանել առկա ստատուս քվոն և պաշտպանել կատարումները հարակից իրավունքների համակարգի շրջանակում` հաշվի առնելով կատարումների յուրահատկությունները: Բացի դրանից հոդվածը վեր է հանում այն դեպքերը, երբ կատարումները կարող են պաշտպանվել ինչպես հեղինակային իրավունքով, այնպես էլ հարակից իրավունքներով:
ՄԻՆՉԴԱՏԱԿԱՆ ՎԱՐՈՒՅԹԻ ՆԿԱՏՄԱՄԲ ԴԱՏԱԿԱՆ ՎԵՐԱՀՍԿՈՂՈՒԹՅԱՆ ԱՐԴՅՈՒՆՔՈՒՄ ԿԱՅԱՑՎԱԾ ԴԱՏԱԿԱՆ ԱԿՏԵՐԻ ԿԱՏԱՐՄԱՆ ԺԱՄԿԵՏԻ ՀԻՄՆԱԽՆԴԻՐԸ
Authors: Ղազինյան Գագիկ , Դանիելյան Անի 
Published: June 2022

Դատական ակտերի վերջնականությունը և պարտադիրությունը պետության իրավական անվտանգության երաշխիքային համակարգի տարրերից է, որոնք ՀՀ օրենսդիրը կապում է դրանք օրինական ուժի մեջ մտնելու իրավաբանական փաստի հետ: Մինչդատական վարույթի նկատմամբ դատական վերահսկողության արդյունքում կայացված դատական ակտերը, որպես գործն ըստ էության չլուծող դատական ակտեր, ուժի մեջ են մտում կայացման/հարապարակման պահին և նույն պահից էլ պարտադիր են կատարման համար: Միևնույն ժամանակ քննարկվող դատական ակտերը կարող են բողոքարկվել վերաքննության, ապա նաև վճռաբեկության կարգերով:
Նման կարգավորումները վիճելի են իրավական որոշակիության սկզբունքի և դրա տարրը հանդիսացող դատական ակտերի վերջնականության չափանիշի համատեքստում: Բացի այդ գործնականում մի շարք խնդիրներ են առաջանում ինչպես առանց բողոքարկման կառուցակարգերը սպառելու դրանց կատարման, այնպես էլ չկատարման դեպքում: Ընդ որում այդ խնդիրները շարունակելու են առկա լինել նաև ՀՀ քրեական դատավարության նոր օրենսգրքի կարգավորումների պայմաններում:
Հիշյալ խնդիրները վերլուծության առարկա են դարձվել հեղինակների կողմից: Մինչդատական վարույթի նկատմամբ դատական վերահսկողության արդյունքում կայացված դատական ակտերի էության, իրավական որոշակիության սկզբունքի և դատական ակտերի վերանյաման կառուցակարգերի համադրված վերլուծության արդյունքում հեղինակների կողմից առաջարկում է խնդրի լուծման երկու մոտեցումներ և քննարկվում ՀՀ օրենսդրությունում դրանց ներդրման հնարավոր կառուցակարգերը:
FROM THE PAST TO THE FUTURE OF EXTRADITION: THE RISE OF A NEW OBLIGATION AS REVERSE EXTRADITION
Authors: BOZ Burak 
Published: June 2022

Extradition is a legal concept that has been grown throughout the history of international relations. However, it is not just a simple result of the everyday headaches of international actors. Extradition, specifically, extradition of common criminals, has also a substantial intellectual background that had been developed by prominent scholars such as Grotius and Beccaria.

The current scope of extradition agreements, whether they are unilateral or bilateral, includes an obligation to surrender a person who has been convicted or suspected. This situation is related to its intellectual background as its history as well.
Recent developments in international law, such as the denaturalization of dual citizens who have been involved in terrorist activities, initiated new legal disputes over whether a state has not any duty to open its borders to someone, who is not its citizen anymore, however, it should be examined that whether states are under an obligation to take and prosecute terrorists in terms of international law.
Consequently, such an obligation is essential for the establishment of international security. Recognition of this obligation as a valid legal institution can only be achieved via a well-structured international treaty.
State Regulation of Wastewater Sludge Management: Current Problems and Ways to Solve Them
Authors: Golovina A. E. , Saparov N. Ch. 
Published: June 2022

The problems of disposal of sewage sludge following the issues of municipal solid waste disposal have become the subject of intense scientific discussion in the professional community. The relevance of the topic is due to the annual increase in the volume of wastewater and, accordingly, its precipitation, a significant part of which is not processed, is drained directly to sludge sites (often to unprepared soil), threatening a significant deterioration in the environmental situation.The authors analyze the practice and problems of regulating relationships related to the management of wastewater sludge, as well as related issues of tariff regulation; proposals on amendments to tariff legislation in the part related to water disposal are formulated and substantiated.
A EDUCAÇÃO EM ANGOLA NO SÉCULO XV AO SÉCULO XXI: UM OLHAR PELA ORGANIZAÇÃO, DESENVOLVIMENTO E PERSPECTIVA DO SECTOR.
Authors: Costa Mário Graça da , Santos e Campos Maria Aparecida 
Published: June 2022

O presente artigo tem como Objectivo conhecer a Educação em Angola do Século XV ao Século XXI, olhando pela organização, desenvolvimento e perspectiva do Sector. A educação considera-se como meio fundamental para a socialização do indivíduo e a escola como agência do mesmo processo e sua missão é optimizar a assimilação dos conteúdos linguísticos e de outro tipo de formação de pessoas competentes desde o ponto de vista comunicativo e que se realiza na prática. Falar da educação, é falar do passado, do presente e do futuro. A educação em Angola, antes, durante e depois da independência, não deve ser abordada somente numa perspectiva história, mas também devemos analisá-la numa perspectiva sociológica, sentindo-nos quase obrigados” a nos deter no período colonial por ser o marco de referência no surgimento do ensino em Angola. O ensino escolar teve início em Angola nos séculos XVI e XVII, portanto muito antes do actual território constituir-se em uma unidade. Com a independência, se tornou preocupação do Governo em expandir a educação e ensino por todo o país, seja ele público, comparticipado e privado, tornando assim, aquilo que antes foi inacessível, acessível a todos sem excepção ou descriminação, garantindo a qualidade de ensino, a inovação, o empreendedorismo e para as universidades, apoiando – se nos tres pilares fndamentais que são, Ensino, Investigação e Extensão. Espera-se no final da pesquisa, os leitores possam conhecer o percurso histórico da Educação em Angola, do Século XV ao Século XXI.
Overtopping Scour due to Tsunami Bore: Laboratory Study
Authors: Maqtan Raidan , Yusuf Badronnisa , Hamzah Saiful Bahri 
Published: June 2022

Tsunami wave is one of the most serious threats to lives and activities, particularly in coastal cities within 100 m height from the mean sea level. Construction of coastal defense structures, such as seawalls and breakwaters, is the most popular measure adopted by engineers for protection from sea waves, including tsunamis, and mitigation of their effects. Many researchers determined through their post-tsunamis field studies that the scour at the landward toe of coastal defense structures induced by tsunami overtopping is the predominant cause of structural failures. İn the present study, a series of laboratory experiments was conducted at National Hydraulic Research Institute of Malaysia to investigate the scour profile at the landward toe of a vertical seawall induced by tsunami bore overtopping vertical seawall and examine the influence of breakwater and bore characteristics on the induced scour depth and length. The experiments showed that the breakwater in low initial depth conditions was more effective in reducing bore velocity and scour depth at the landward toe of the seawall than that in high initial depth conditions. Moreover, a strong positive relationship was confirmed between the Froude number of the overtopping flow and the induced scour depth and length.
HIGHLIGHTS

The most common cause of the coastal structural failure is scour at the landward toe of coastal defense structures caused by tsunami overtopping
A series of laboratory tests were carried out to explore the scour profile at the landward toe of a vertical seawall caused by a tsunami bore overtopping it, as well as the impact of breakwater and bore features on the induced scour depth and length
The Froude number of the overtopping flow and the resultant scour depth and length were shown to have a strong positive relationship