bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of voice assistant recommendations on consumer behavior
Authors: Flavián Carlos , Akdim Khaoula , Casaló Luis V. 
Published: November 2022

AbstractThe present study compares the influence of text‐based recommendations; traditionally known as online consumer reviews, and the influence of voice‐based recommendations provided by voice‐driven virtual assistants on consumer behaviors. Based on media richness theory, the research model investigates how voice versus text modality influences consumers' perceptions of credibility and usefulness, as well as their behavioral intentions and actual behaviors. In addition, the study analyses if these relationships vary based on the type of product and compares the influence of masculine and feminine voices. Two studies were conducted using between‐subjects experimental designs, partial least squares‐structural equation modeling, and logistic regression. The core finding is that voice‐based recommendations are more effective than online consumer reviews in altering consumer behaviors. In addition, the first study showed that the influence of recommendations on behavioral intentions is mediated by consumers' perceptions of their credibility and usefulness. The second study confirmed, in a realistic setting, that voice‐based recommendations affect consumer choices to a greater extent. Recommendations for search products and provided by males are also found to be more effective. These results contribute to the voice assistant and e‐WOM literature by highlighting the effectiveness of voice‐based recommendations in predicting consumer behaviors, confirming that credibility and usefulness are key factors that determine the influence of recommendations, and showing that recommendations are more effective when they focus on search products.
A Thermodynamic Simulation Package for Catalytic Polyolefin Reactors: Development and Applications
Authors: Alizadeh Arash , Touloupidis Vasileios , Soares João B. P. 
Published: November 2022

AbstractA thermodynamic simulation package is developed for the catalytic polymerization of olefins in autoclave slurry, loop slurry, gas‐phase, and autoclave solution reactors. The number of components in the reactors may vary from two to six. The simulator uses the Sanchez–Lacombe theory, one of the major thermodynamic models in the polymer industry. Step‐by‐step instructions on how to specify the system, derive and solve the resulting nonlinear equations, and estimate the required thermodynamic properties are given. The software is used to describe ethylene/1‐hexene copolymerizations with hydrogen in different reactors under industrial conditions. These simulations demonstrate why thermodynamic effects must be included in olefin polymerization models.
Knowledge of young people living with type 1 diabetes and their caregivers about its management
Authors: Owusu Bernard Afriyie , Ofori‐Boateng Prince , Forbes Angus , Doku David Teye 
Published: November 2022

AbstractAims and ObjectiveWe sought to investigate knowledge and skills of type 1 diabetes (T1D) management among young people living with the disease and their caregivers. Our aim is to provide baseline evidence to inform T1D self‐management education for young people living with the disease and their caregivers.BackgroundBoth local and international guidelines recommend ongoing T1D self‐management education for people living with the disease. This is because T1D often develops among young people who rarely have the competencies to adequately manage their condition. However, the extent to which young people living with T1D and their caregivers can self‐manage this chronic disease in a low‐resource country like Ghana is unknown.MethodsUsing a phenomenological study design, semi‐structured interviews were conducted with 28 young people living with type 1 diabetes, 12 caregivers and 6 healthcare providers in southern Ghana. Data were collected at homes, hospitals and support group centres of participants via face‐to‐face interviews, photovoice and video‐conferencing. The data were analysed thematically using QSR NVivo 11.ResultsThe young people living with T1D and their caregivers demonstrated knowledge and skills in the self‐monitoring of blood glucose, and the treatment of hyperglycaemia. Areas of more marginal or lack of knowledge were concerning carbohydrate counting, severe hypoglycaemia and the management of intercurrent illnesses. Young persons living with T1D and their caregivers received their management information from healthcare and non‐healthcare providers. Access to diabetes self‐management education influenced T1D management knowledge and practices.ConclusionYoung people living with type 1 diabetes and their caregivers possessed limited scope of knowledge on type 1 diabetes self‐management. Multiple sources of T1D knowledge were found, some of which may not be helpful to patients. The knowledge gaps identified compromises transitional independence and self‐management capacity.Relevance to Clinical PracticeIt is important for clinicians and organizations that provide T1D education to provide diabetes self‐management education also on managing hypoglycaemia, carbohydrate counting and managing T1D during intercurrent life events among young people living with T1D.No Patient or Public ContributionPatients and their caregivers were interviewed as research participants. They did not conceptualize, analyse, interpret or prepare the manuscript.
Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride‐induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO‐1/NF‐κB signaling
Authors: Alsharif Khalaf F. , Albrakati Ashraf , Al Omairi Naif E. , Almalki Abdulraheem S. , Alsanie Walaa , Abd Elmageed Zakaria Y. , Alharthi Fahad , Althagafi Hussam A. , Alghamdi Abdullah A. A. , Hassan Ibrahim Eid , Habotta Ola A. , Lokman Maha S. , Kassab Rami B. , El‐Hennamy Rehab E. 
Published: November 2022

AbstractProdigiosin (PDG) is a bacterial metabolite with numerous biological and pharmaceutical properties. Exposure to aluminium is considered a root etiological factor in the pathological progress of Alzheimer's disease (AD). Here, in this investigation, we explored the neuroprotective potential of PDG against aluminium chloride (AlCl3)‐mediated AD‐like neurological alterations in rats. For this purpose, rats were gavaged either AlCl3 (100 mg/kg), PDG (300 mg/kg), or both for 42 days. As a result of the analyzes performed on the hippocampal tissue, it was observed that AlCl3 induced biochemical, molecular, and histopathological changes like those related to AD. PDG pre‐treatment significantly decreased acetylcholinesterase activity and restored the levels of brain‐derived neurotrophic factor, monoamines (dopamine, norepinephrine, and serotonin), and transmembrane protein (Na+/K+‐ATPase). Furthermore, PDG boosted the hippocampal antioxidant capacity, as shown by the increased superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione contents. These findings were accompanied by decreases in malondialdehyde and nitric oxide levels. The antioxidant effect may promote the upregulation of the expression of antioxidant genes (Nrf2 and HO‐1). Moreover, PDG exerted notable anti‐inflammatory effects via the lessening of interleukin‐1 beta, tumor necrosis factor‐alpha, cyclooxygenase‐2, nuclear factor kappa B, and decreases in the gene expression of inducible nitric oxide synthase. In addition, noteworthy decreases in pro‐apoptotic (Bax and caspase‐3) levels and increases in anti‐apoptotic (Bcl‐2) biomarkers suggested an anti‐apoptotic effect of PDG. In support, the hippocampal histological examination validated the aforementioned changes. To summarize, the promising neuromodulatory, antioxidative, anti‐inflammatory, and anti‐apoptotic activities of PDG establish it as a potent therapeutic option for AD.
Stellenwert der Immuntherapie in der perioperativen Behandlung des lokalisierten muskelinvasiven Harnblasenkarzinoms
Authors: Lewerich J. , Schmid S. C. , Gschwend J. E. , Retz M. 
Published: November 2022

ZusammenfassungImmun-Checkpoint-Inhibitoren (ICI) sind als Erst- und Zweitlinientherapien beim metastasierten bzw. lokal fortgeschrittenen Urothelkarzinom als Standard etabliert. Der perioperative Einsatz der Immuntherapie steht nun im Fokus aktueller Entwicklungen und Forschung in der Uroonkologie. Aktuelle Studien untersuchen ICI als Monotherapie oder in Kombination mit Chemotherapie oder Bestrahlung im perioperativen Setting. Dieser Artikel soll einen Überblick über die neuen Studienkonzepte, die aktuell publizierten Daten und daraus entstehenden Therapiekonzepte sowie einen Ausblick auf zukünftige Entwicklungen bieten.
Allografts as alternative to autografts in primary posterior cruciate ligament reconstruction: a systematic review and meta-analysis
Authors: Migliorini Filippo , Pintore Andrea , Oliva Francesco , Eschweiler Jörg , Bell Andreas , Maffulli Nicola 
Published: November 2022

Abstract
Purpose
Following posterior cruciate ligament (PCL) rupture, autografts and allografts are routinely used for its reconstruction. This study investigated the efficacy and safety of allografts for primary PCL reconstruction, comparing them to autografts in terms of patient-reported outcome measures (PROMs), functional tests, and complications.

Methods
This study followed the PRISMA guidelines. PubMed, Web of Science, Google Scholar, Embase, and Scopus were accessed in October 2022. All the clinical studies investigating the outcomes of primary PCL reconstruction using allografts, or comparing the outcomes of allografts versus autografts, were accessed. The outcomes of interests were: instrumental laxity, range of motion (ROM), Telos stress radiography, drawer test, International Knee Documentation Committee (IKDC), Tegner Activity Scale, and the Lysholm Knee Scoring Scale. Data on complications were also recorded.

Results
A total of 445 patients were included. The mean follow-up was 45.2 ± 23.8 months. The mean age of the patients was 30.6 ± 2.2 years. The time span between the injury and surgical intervention was 12.9 ± 10 months. Overall, 28% (125 of 445 patients) were women. Good baseline comparability was found between the two cohorts. No difference was found in terms of Lysholm Score, ROM, Tegner Scale, IKDC, arthrometer laxity, drawer test, and Telos stress radiography. No difference was found in the rates of anterior knee pain and revision.

Conclusion
Allografts can be considered a suitable alternative to autografts for PCL reconstruction.

Level of evidence
III.
Results from the First-in-Human Study of the Caterpillar™ Arterial Embolization System
Authors: Holden Andrew , Mwipatayi Bibombe P. , Khashram Manar , Dubenec Steven , Goh Gerard S. , Settlage Richard A. 
Published: November 2022

Abstract
Purpose
To assess occlusion success and adverse events associated with the use of a self-expanding device for peripheral artery embolization.

Methods
This prospective, single-arm, feasibility study was conducted using the Caterpillar™ Arterial Embolization Device composed of opposing nitinol fibers and a flow-occluding membrane. Twenty patients (24 embolization sites) were treated at four investigational centers in New Zealand and Australia and followed for 30 days. Embolization sites included mesenteric, accessory renal, and iliac arteries and their branches. Primary outcome measures were peri-procedural occlusion confirmed by angiography and freedom from device-related serious adverse events (SAEs) at 30 days. Secondary observations included time to occlusion and assessment of adverse events.

Results
Peri-procedural occlusion was 100%, and freedom from a device-related SAE was 94.7% at 30 days. One patient had abdominal bloating that required hospitalization deemed possibly related to the device or procedure. Twenty-two of 24 embolization sites were occluded with one device (91.7%). Mean procedure duration was 11.7 ± 8.6 min (device deployment time: 1.8 ± 1.0 min), and mean fluoroscopy time was 241 ± 290.7 s. All embolization sites occluded during the procedure with 62.5% occluded within three minutes and 91.6% occluded within ten minutes. No devices migrated or required re-embolization. Freedom from device- and procedure-related adverse events was 84.2%. One patient died from aortic rupture during a subsequent adjunctive abdominal aortic endovascular procedure deemed unrelated to the embolization device or procedure.

Conclusions
This first-in-human study of the Caterpillar embolization device achieved peri-procedural occlusion in all patients with a 94.7% freedom from device-related SAE at 30 days.

Level of Evidence
Level 2b—prospective, multicenter, single-arm, first-in-human clinical study. Pre-specified endpoints were analyzed using descriptive statistics.
Systematic review of associations between concomitant rheumatoid arthritis and peripheral arterial disease, health-related quality of life and functional capacity
Authors: Zoubi Tayser , Gordon Hendry 
Published: November 2022

AbstractPatients with rheumatoid arthritis (RA) are at an increased risk of cardiovascular disease and vascular morbidity. The association between peripheral arterial disease (PAD) and RA has not been previously investigated within the scope of a review. Conjoined disease manifestations may impact patient well-being, perpetuating increased mortality and quality of life deficits. To investigate the association between RA and PAD, along with RA and the ankle-brachial pressure index (ABPI), the impact of disease concomitance on health-related quality of life (HRQOL) and functional capacity (FC) was also investigated. Individual study appraisal was completed using the Crowe Critical Appraisal Tool (CCAT). A level of evidence analysis was conducted using the American Society of Plastic Surgeons (ASPS) Evidence Rating Scale for Prognostic/Risk Studies. AMED®, CINAHL®, Health Source: Nursing/Academic Edition, MEDLINE®, AHFS®, Scopus, Web of Science, Cochrane Library and Google scholar. Ten studies produced a CCAT rating of ≥ 30 (75%) and were deemed high quality, while a single study demonstrated a score of 26 (65%) suggesting moderate quality. A grade “II” levels of evidence was awarded to positive association between RA and PAD. A gradation of “I” was awarded to the association between ABPI and RA. The impact of concomitant manifestations on HRQOL and FC did not qualify for a level of evidence analysis. The systematic inflammatory nature of RA likely contributes to the increased incidence of PAD within the population. Further investigations are required to ascertain the impact of conjoined disease manifestations on HRQOL and FC.
Generalized Analytical Results on n-Ejection–Collision Orbits in the RTBP. Analysis of Bifurcations
Authors: M-Seara T. , Ollé M. , Rodríguez Ó. , Soler J. 
Published: November 2022

AbstractIn the planar circular restricted three-body problem and for any value of the mass parameter $$\mu \in (0,1)$$

μ
∈
(
0
,
1
)

and $$n\ge 1$$

n
≥
1

, we prove the existence of four families of n-ejection–collision (n-EC) orbits, that is, orbits where the particle ejects from a primary, reaches n maxima in the (Euclidean) distance with respect to it and finally collides with the primary. Such EC orbits have a value of the Jacobi constant of the form $$C=3\mu +Ln^{2/3}(1-\mu )^{2/3}$$

C
=
3
μ
+
L

n

2
/
3

(
1
-
μ
)

2
/
3

, where $$L>0$$

L
>
0

is big enough but independent of $$\mu $$
μ
and n. In order to prove this optimal result, we consider Levi-Civita’s transformation to regularize the collision with one primary and a perturbative approach using an ad hoc small parameter once a suitable scale in the configuration plane and time has previously been applied. This result improves a previous work where the existence of the n-EC orbits was stated when the mass parameter $$\mu >0$$

μ
>
0

was small enough. Moreover, for decreasing values of C, there appear some bifurcations which are first numerically investigated and afterward explicit expressions for the approximation of the bifurcation values of C are discussed. Finally, a detailed analysis of the existence of n-EC orbits when $$\mu \rightarrow 1$$

μ
→
1

is also described. In a natural way, Hill’s problem shows up. For this problem, we prove an analytical result on the existence of four families of n-EC orbits, and numerically, we describe them as well as the appearing bifurcations.
High resolution projections for extreme temperatures and precipitation over Greece
Authors: Politi Nadia , Vlachogiannis D. , Sfetsos A. , Nastos P. T. 
Published: November 2022

AbstractThe present study investigated future temperature and precipitation changes over Greece using the Weather Research and Forecasting (WRF) model. WRF was driven by EC-EARTH over Greece at very high resolution for the historical period (1980–2004), along with projected simulations, in the near future (2025–2049) and far future (2075–2099) under the Representative Concentration Pathways 4.5 (RCP4.5) and 8.5 (RCP8.5). Climatic variables were produced at 5-km grid spacing and 6-h interval. The historical simulation was evaluated against the available station observations. The analysis showed that the model underestimated the maximum temperatures and slightly overestimated the minimum temperatures. Also, the model simulated a small dry bias in precipitation with an excellent representation of the spatial patterns. The model projections for temperature under the two emission scenarios compared to the historical simulation revealed a robust magnitude of future warming with the most pronounced changes predominantly over the eastern areas of the country under the RCP8.5 in the far future. Projected precipitation changes were more evident in the far future with an overall decrease of the annual precipitation all over the eastern part of the country (with islands included) with the most dramatic reductions (above 40%) of seasonal precipitation observed under RCP8.5. Increases in the number of hot days were found everywhere with more pronounced changes over the plain areas under RCP8.5 in the far future. Significant increases of dry days were projected over the eastern part of the mainland and more intensely under RCP8.5 in the far future.
Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study
Authors: El-Tahlawi S. R. , Ramadan A. H. , Shaker O. G. , Hilal R. F. 
Published: November 2022

AbstractRecurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-17A and F gene polymorphisms are found in cases of RDPV. It included 100 cases of RDPV and 100 age and sex matched controls, from which EDTA blood samples were taken for single-nucleotide polymorphism analysis. IL-17A (rs2275913) and F (rs763780) were associated with a significantly increased incidence of developing RDPV. IL-17A and F gene polymorphism could be implicated as a risk factor for the development of RDPV.
Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents
Authors: Lenz Bernd , Gerhardt Sarah , Boroumand-Jazi Rafat , Eichler Anna , Buchholz Verena Nadine , Fasching Peter A. , Kornhuber Johannes , Banaschewski Tobias , Flor Herta , Guldner Stella , Prignitz Maren , Nees Frauke ,   IMAC-Mind Consortium
Published: November 2022

AbstractPrenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC; β = 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb; β = – 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model.
Towards clinical application of implantable brain–computer interfaces for people with late-stage ALS: medical and ethical considerations
Authors: Vansteensel Mariska J. , Klein Eran , van Thiel Ghislaine , Gaytant Michael , Simmons Zachary , Wolpaw Jonathan R. , Vaughan Theresa M. 
Published: November 2022

AbstractIndividuals with amyotrophic lateral sclerosis (ALS) frequently develop speech and communication problems in the course of their disease. Currently available augmentative and alternative communication technologies do not present a solution for many people with advanced ALS, because these devices depend on residual and reliable motor activity. Brain–computer interfaces (BCIs) use neural signals for computer control and may allow people with late-stage ALS to communicate even when conventional technology falls short. Recent years have witnessed fast progression in the development and validation of implanted BCIs, which place neural signal recording electrodes in or on the cortex. Eventual widespread clinical application of implanted BCIs as an assistive communication technology for people with ALS will have significant consequences for their daily life, as well as for the clinical management of the disease, among others because of the potential interaction between the BCI and other procedures people with ALS undergo, such as tracheostomy. This article aims to facilitate responsible real-world implementation of implanted BCIs. We review the state of the art of research on implanted BCIs for communication, as well as the medical and ethical implications of the clinical application of this technology. We conclude that the contribution of all BCI stakeholders, including clinicians of the various ALS-related disciplines, will be needed to develop procedures for, and shape the process of, the responsible clinical application of implanted BCIs.