bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF TRUST IN THE PROTECTION SYSTEM OF THE INFORMATION RESOURCE OF THE VEHICLE BASED ON THE NAVIGATION KEY
Authors: Аралбаев Ташбулат Захарович , Галимов Ринат Равилевич , Сарайкин Александр Иванович 
Published: May 2022

В статье определена актуальность задачи обеспечения информационной безопасности информационного ресурса (ИР) автомобильных транспортных средств (АТС), обусловленная увеличением степени использования информационных технологий в современных транспортных средствах и наличием уязвимостей в штатных средствах защиты. Проведен обзор литературы и выявлены недостатки существующих решений систем защиты доступа (СЗД) к ИР АТС. Определена перспективность подхода к защите ИР АТС, учитывающего взаимное расположение субъекта и объекта доступа. Предложена формализованная процедура оценки доверия к многоуровневой системе защиты доступа к ИР АТС на основе навигационного ключа, учитывающая характеристики и условия эксплуатации информационной системы, требования защиты, текущую конфигурацию мер и средств защиты. Представлены алгоритмическая модель и метод оценки доверия к системе защиты на основе системы признаков и кодов защиты. Приведены расчеты оценки доверия к системе защиты ИР автомобиля.
The article proposes a method for assessing the quality of an access protection system (APS) to information resources (IR) of a motor vehicle (MV) using a navigation key. The urgency of the tasks of ensuring the information security of IR MV is determined, due to the increase in the degree of use of information technologies in modern vehicles and the presence of vulnerabilities in the standard means of protection. The conducted literature review revealed the shortcomings of existing APS solutions to information resources of motor vehicle. The prospect of an approach to the protection of IR MV, taking into account the mutual location of the subject and the object of access, has been revealed. A model is proposed for assessing confidence in a multi-level security system for access to the IR of a motor vehicle based on a navigation key, which takes into account the characteristics and operating conditions of the MV information system, security requirements and the current configuration of security measures and means. An algorithmic model and a method for assessing the effectiveness of access protection based on a system of signs and protection codes are presented. Calculations of the quality assessment of the access protection system to IR are presented.
TOWARDS THE PROTECTED CYBERSPACE RISK MAPPING PLATFORM
Authors: Сердечный Алексей Леонидович , Гончаров Андрей Андреевич , Булычев Максим Александрович , Коноплин Александр Васильевич , Газизянов Олег Сергеевич , Дыкин Роман Олегович , Нестеров Дмитрий Сергеевич , Нархов Дмитрий Андреевич 
Published: May 2022

Статья посвящена перспективам создания платформы картографирования рисков защищаемого киберпространства, потребность в которой обусловлена нарастанием неопределённости в отношении процессов, протекающих в киберпространстве. Наглядное представление таких процессов позволяет своевременно выявлять и провести исследование опасных тенденций для безопасности личности, общества и государства. В данной работе формулируются цели, задачи и функциональные требования к платформе картографирования рисков. Представленные результаты основаны на практическом опыте разработки и применения методологии картографирования защищаемого киберпространства, который был получен в ходе разработки системы картографирования рисков защищаемого киберпространства (прототип разрабатываемой платформы). Целью создания платформы является объединение усилий множества исследователей киберпространства благодаря обеспечению совместной работы по его представлению в виде системы взаимосвязанных информационных карт. Вниманию научной общественности предлагается облик платформы картографирования рисков защищаемого киберпространства и возможные решения, которые могут быть использованы для её воплощения в виде готового продукта.
The article deals with the prospects of creating the platform for risk mapping of protected cyberspace, the need for which is due to increasing uncertainty about the processes occurring in cyberspace. A visual representation of such processes allows timely identification and investigation of dangerous trends for the security of individuals, society and the state. This paper formulates the goals, objectives and functional requirements for a risk mapping platform. The results presented are based on practical experience in the development and application of a protected cyberspace mapping methodology, which was obtained during the development of a protected cyberspace risk mapping system (prototype of the platform). The purpose of developing the platform is to bring together multiple researchers of cyberspace by enabling them to work together to represent it as a system of interconnected information maps. The scientific community is offered the appearance of the platform for risk mapping of protected cyberspace and possible solutions, which can be used for its implementation in the form of a finished product.
Pharmacogenetics and Pharmacokinetic of Azithromycin Eyedrops in Meibomian Gland Dysfunction Treatment
Authors: Riza Gustam Syena Damara 
Published: May 2022

Meibomian gland dysfunction (MGD) is the leading cause of ocular surface disease throughout the world, which has a prevalence that varied widely from 3.5 to 70% according to age, sex, and ethnicity. Azithromycin (AZM) is the first azalidic antibiotic, a class of macrolide antibiotics, which has derived from erythromycin. It is widely used in clinical practice, not only for respiratory diseases and sexually transmitted infections but also for ocular diseases. azithromycin suppressed zymosan-induced mRNA expression and protein production of proinflammatory cytokines (tumor necrosis factor α and IL-1β), chemokines (IL-6 and RANTES), and MMPs (MMP-1, MMP-3, and MMP-9) by human corneal epithelial cells and suggested the potential for using azithromycin to treat ocular surface It controls the initiation and resolution of inflammatory responses through the regulation of chemotaxis, activation, and survival of lymphocytes. The anti-inflammatory role of TGF-β1 has been recognized in different cell types by inhibiting proinflammatory cytokines including tumor necrosis factor α, IL-1, and interferon γ.The combination of a topical AZM solution 1.0% with corticosteroid (DEX 0.1%) was found superior in the comprehensive treatment of MGD after 2 weeks. AZM is a one of the safest antibiotics, well tolerated, and has special pharmacokinetic properties. Moreover, it has a broad antimicrobial spectrum. AZM is efficacious for the treatment of a lot of ocular diseases and may be included as monotherapy or in combination therapy in new treatment protocols for more ocular infections.
Relationship Between History of Hormonal Contraception with Hormonal Receptor’s Expression on Breast Cancer Patients in Mohammad Hoesin General Hospital Palembang
Authors: Maududy Al , Halbana  , Mulawan Umar  , Bahar Erial  
Published: May 2022

Background: Cancers with esterogen receptor negative (ER-) have a worse prognostic than estrogen receptor positive (ER +). Research by Cooper at al and Huiyan Ma et al have found strong association between history of hormonal contraceptive use and breast cancer with receptor negative estrogen (ER -). However, another study from Cotterchio et al found no difference.
Methods: This study investigated breast cancer patients who went to dr. Moh Hoesin Palembang. This study involved 200 respondents with data obtained using patient immunohistochemical data and interviews using a questionnaire. This study uses a cross sectional analysis method. Data were obtained from the history of use of hormonal contraception, the type of hormonal contraception, and the status of hormonal receptors (Esterogen Receptors (ER) and Progesterone receptors (PR). 2x2 tables were used to obtain the Prevalence Ratio (PRR) and chi quare to obtain p values.
Results: The results of the Chi square analysis showed that there was no significant relationship between the history of hormonal contraception and negative receptor expression with the prevalence ratio of hormonal contraceptives and ER (-) 1.48 times and PR (-) 1.43 times. There was no significant relationship between type of contraception and negative ER PR. The highest relative risk is in implant contraception with 1.54 times for ER (-) and 1.8 times for PR (-)
Conclusion: There was no relationship between the history of hormonal contraception and negative hormonal receptors
Characteristics of Maxilofacial Fractures That Entered the ER at Dr. Mohammad Hoesin General Hospital Palembang Period 1 January 2019 - 31 December 2019
Authors: Bram Permadi Tant  , Arief Abda 
Published: May 2022

Background: Maxillofacial trauma is a wound or injury that affects the face and jaw.1 Trauma to the hard tissues of the face can cause maxillofacial fractures, which is damage or breaking of the continuity of the facial bones. Traffic accidents remain the main cause of maxillofacial injury, followed by violence, sports, work-related injuries, and falls 9,10,11,12 The high number of traffic accidents and violence in Palembang city can increase the risk of maxillofacial fracture. The absence of data regarding the characteristics of patients with maxillofacial fractures at Dr. Mohammad Hoesin General Hospital Palembang became the reason for this research.
Methods: This research is a descriptive observational study with a cross sectional design using secondary data through patient medical records for the period January 2019- December 2019.
Results: There were 89 patients with maxillofacial fractures with complete medical record data. There were more men (83.14%) than women (16.85%). The youngest age of the patient was 7 years, while the oldest age was 70 years, with the mean age of the patient was 29 years. Traffic accidents were the most common cause (79.7%) followed by falls (11.2 %), violence (4.4 %), sports accidents (1.1 %), and other causes (3.3%). 28 fracture locations were recorded on the upper face, 55 with fracture locations at the midface, 26 with fracture locations on the lower face. The zygomaticomaxillaris complex fracture was the most common fractured bone (35.9%). Regarding management, most were managed with ORIF (66.2%) followed by elevated craniotomy (16.85%), conservative (12.35%), soft tissue debridement repair (2.2%) and closed reduction and nasal repositioning (2.2%).
Conclusion: Maxillofacial fracture are found commonly in men. Most patient age ranges. is the age of 21-30 years. The most common cause is traffic accidents. The most frequently affected fracture site is the midface, where the most commonly affected bone is the zygomaticomaxillaris complex. The treatment option most often applied is ORIF.
Platelet/Lymphocyte Ratio Accuracy as Predictor of Neo-Adjuvant Chemotherapy Response in Locally Advanced Breast Cancer at Dr. Mohammad Hoesin General Hospital Palembang
Authors: Abdur Rahman  , Umar Mulawan , Erial Bahar  
Published: May 2022

Background: Platelet/lymphocyte ratio (PLR) is considered as predictor for chemotherapy response in locally advanced breast cancer undergoing neo-adjuvant chemotherapy. This study aims to evaluate the relationship between the platelet/lymphocyte ratio and neo-adjuvant chemotherapy response in patients with locally advanced breast cancer at Dr. Mohammad Hoesin General Hospital Palembang.
Methods: This study is a prognostic test of the platelet/lymphocyte ratio accuracy to predict the response of neo-adjuvant chemotherapy in patients with locally advanced breast cancer. The study included 113 subjects.
Results: From 113 patients, the PLR cut off point value was 206.83 with an under curve area (AUC) of 91.8%. The results of the PLR prognostic test were sensitivity of 98%, specificity of 87%, Positive Predictive Value of 95%, Negative Predictive Value of 93%, and 95% of accuracy. There was a significant relationship between PLR and chemotherapy response in patients with locally advanced breast cancer (p = 0.000).
Conclusion: There was a significant relationship between PLR on chemotherapy response. PLR can be used as a predictor of neo-adjuvant chemotherapy response with a good degree of accuracy.
Sensitivity and Specificity of Ultrasonographic Compared with CT Angiography in Detecting Femoropopliteal and Infrapopliteal Arterial Lesions in Lower Extremity Arterial Disease in Dr. Mohammad Hoesin General Hospital Palembang
Authors: Radi Noorsyawal  , Kemas Dahlan  , Hanna Marsinta  , Irfannuddin  
Published: May 2022

Background: Peripheral artery disease (PAD) is a chronic occlusive arterial disease of the extremities caused by atherosclerosis.1 It is estimated that 20-30% of the population worldwide suffered PAD.2 PAD is associated with a 1-year mortality and limb loss rate of 20%.7 Critical limb ischemia (CLI) is a late stage clinical presentation of PAD. Imaging of the entire artery is possible using CT angiography. However, CT angiography has its drawbacks because the contrast used can be nephrotoxic, the risk of allergies, expensive, and not all health services have it. Ultrasonographic’s (USG) sensitivity, specificity and accuracy were 96.55%, 61.53%, and 78.84% for detecting lower limb distal artery lesions.11 Ultrasonographic does not require the use of contrast, radiation, low cost and almost all health services have them.12 However, the Ultrasonographic examination has its limitations depending on the operator's capabilities. It is therefore necessary to conduct research that have never been previously studied in South Sumatra.
Methods: This study is a diagnostic test study that examines the sensitivity and specificity of ultrasound in detecting LEAD artery lesions. The samples were 29 patients.
Results: At the femoropopliteal level, the results obtained were 91% sensitivity and 86% specificity. At the infrapopliteal level, the results obtained were 95% sensitivity and 87% specificity.
Conclusion: Ultrasonographic has high sensitivity and specificity in detecting LEAD’s lesions
FOREIGN BODIES OF THE UPPER DEPARTMENTS OF THE GASTROINTESTINAL TRACT
Authors: Krivoruchko І. А. , Lopatenko D. Ye. , Tonkoglas О. А. , Sikal М. О. , Sivozhelizov А. V. 
Published: May 2022

In recent years, the number of patients with foreign bodies in the gastrointestinal tract who need hospital treatment has increased significantly. However, in some cases there are complications that lead to death or require complex reconstructive surgery.
Objective: to improve the results of treatment of patients with gastrointestinal foreign bodies by improving treatment tactics.
Materials and methods: the object of the study were 223 patients who sought help in the “Regional Clinical Hospital” Kharkiv in the period from 2016 to 2021. Particular attention was paid to aggressive foreign bodies (alkaline batteries, wedged in the esophagus). projects and more).
Results: foreign bodies were removed in the shortest possible time by esophagogastroduodenoscopy.
Conclusions:
1. Dynamic monitoring of a swallowed foreign body without its endoscopic removal is recommended when patients have no clinical symptoms and the foreign body is blunt, inert and small, is there is a guarantee of its safe involuntary discharge.

Flexible endoscopy — the best diagnostic and therapeutic method for foreign bodies in the upper gastrointestinal tract, with a success rate of 95%
Emergency, within 2 hours of admission, endoscopic intervention is recommended for foreign bodies that have caused complete obstruction of the esophagus, as well as for acute foreign bodies and batteries located in the esophagus.
MODERN ASPECTS OF PREDICTING THE COURSE OF ACUTE PERITONITIS
Authors: Bilyayeva O. O. , Karol I. V. 
Published: May 2022

The aim of this research was to highlight modern aspects of predicting the course of acute peritonitis by applying prognostic scales.
Matherials and methods. The study included 265 patients with peritonitis of various origins, who were treated in the surgical department of Brovary Multidisciplinary Clinical Hospital during 2020.
Results. In most patients (194 (73,2 %)) Mannheim peritoneal index (MPІ) was grade I. In 63 (23,8 %) patients the II degree was determined and in 8 (3,0 %) — the III degree of MPІ. Among the patients there were 5 deaths, which was 1,9 %. When evaluating the modified APACHE II scale, most patients (23,0 %) were in the range of 0-1 points, slightly less (22,6 %) — in the range of 2-3 points and a significant proportion (21,9 %) were in the range of 10-20 points. Of the 5 fatalities among the study patients, all had a modified APACHE II score of more than 10 points.
Conclusions. To predict the course of peritonitis, the Mannheim peritoneal index and the modified APACHE II scale are objective methods for determining the degree of endotoxicosis, which allow to predict the course of the disease quite accurately and quickly. Among the patients of the study there were 5 fatal cases: in 4 of them MIP was 3 degrees and 1 case — 2 degrees. Of the 5 fatalities, all patients had a modified APACHE II score of more than 10.
PECULIARITIES OF SYMPTOMATIC ACQUIRED LACRIMAL OUTFLOW OBSTRUCTION IN PATIENTS WITH DIABETES MELLITUS DEPENDING ON THE DEGREE OF ITS COMPENSATION
Authors: Bezditko P. A. , Bezega N. M. 
Published: May 2022

The aim was to identify the features of symptomatic ALOO in patients with type 2 diabetes mellitus (DM2) depending on the degree of its compensation.
Materials and methods. The study included 56 patients with symptomatic ALOO and DM2. Patients were divided into groups according to the degree of compensation of DM2: 29 patients with decompensated DM2 (HbA1c > 7.5 %), 14 patients with subcompensated DM2 (HbA1c — 7.1–7.5 %), 13 patients with compensated DM2 (HbA1c < 7.1 %).
In addition to standard, ophthalmic methods included measuring the size of the lacrimal punctum, the height of the lacrimal meniscus, diagnostic tests to determine tear production (Schirmer, Jones, Norn test), lacrimal, larimal suction test, and reflux test, assessment of lacrimal system balance, diagnostic lavage of lacrimal outflow system, probing of the lacrimal ducts.
Results. Decompensated DM2 (51.8±6.7 % of patients) occurred in patients with symptomatic ALOO 2.1 and 2.2 times more often than subcompensated ((25±5.8) % of patients) and compensated DM2 ((23.2±5,7) % of patients), respectively (p<0,05). The frequency of bilateral lesions among patients with decompensated DM2 ((58.6±9.2) % of patients) was on average 1.8 times higher than in patients with subcompensated ((35.7±12.8) % of patients) and compensated DM2 ((30,8±12.8) % of patients) (p <0.05). The frequency of complete obstruction in patients with compensated DM2 ((52.9±2.1) % of the eyes) was on average 1.5 times lower than in patients with subcompensated ((79±9.3) % of the eyes) and decompensated DM2 ((78.3±6.1) % of eyes) (p<0.05). The frequency of blepharitis in decompensated DM2 ((79.3±7.5) % of patients) was on average 1.3 times higher than that in compensated ((64.3±13.3) % of patients) and subcompensated DM2 ((61.5±13.0) %) patients (p<0.05).
Conclusions. Symptomatic ALOO is more common in patients with decompensated DM2. In patients with DM2 features of symptomatic ALOO depend on degree of compensation of DM2.
An Aligned Orbit for the Young Planet V1298 Tau b
Authors: Johnson Marshall C. , David Trevor J. , Petigura Erik A. , Isaacson Howard T. , Van Zandt Judah , Ilyin Ilya , Strassmeier Klaus , Mallonn Matthias , Zhou George , Mann Andrew W. , Livingston John H. , Luger Rodrigo , Dai Fei , Weiss Lauren M. , Močnik Teo , Giacalone Steven , Hill Michelle L. , Rice Malena , Blunt Sarah , Rubenzahl Ryan , Dalba Paul A. , Esquerdo Gilbert A. , Berlind Perry , Calkins Michael L. , Foreman-Mackey Daniel 
Published: May 2022

Abstract
The alignment of planetary orbits with respect to the stellar rotation preserves information on their dynamical histories. Measuring this angle for young planets helps illuminate the mechanisms that create misaligned orbits for older planets, as different processes could operate over timescales ranging from a few megayears to a gigayear. We present spectroscopic transit observations of the young exoplanet V1298 Tau b; we update the age of V1298 Tau to be 28 ± 4 Myr based on Gaia EDR3 measurements. We observed a partial transit with Keck/HIRES and LBT/PEPSI, and detected the radial velocity anomaly due to the Rossiter–McLaughlin effect. V1298 Tau b has a prograde, well-aligned orbit, with

λ
=

4

−
10

+
7

deg. By combining the spectroscopically measured

v
sin

i

⋆

and the photometrically measured rotation period of the host star we also find that the orbit is aligned in 3D,

ψ
=

8

−
7

+
4

deg. Finally, we combine our obliquity constraints with a previous measurement for the interior planet V1298 Tau c to constrain the mutual inclination between the two planets to be i
mut = 0° ± 19°. This measurements adds to the growing number of well-aligned planets at young ages, hinting that misalignments may be generated over timescales of longer than tens of megayears. The number of measurements, however, is still small, and this population may not be representative of the older planets that have been observed to date. We also present the derivation of the relationship between i
mut, λ, and i for the two planets.
A Multiwavelength Study of ELAN Environments (AMUSE2). Mass Budget, Satellites Spin Alignment, and Gas Infall in a Massive z ∼ 3 Quasar Host Halo
Authors: Arrigoni Battaia Fabrizio , Chen Chian-Chou , Liu Hau-Yu Baobab , De Breuck Carlos , Galametz Maud , Fumagalli Michele , Yang Yujin , Zanella Anita , Man Allison , Obreja Aura , Prochaska J. Xavier , Bañados Eduardo , Hennawi Joseph F. , Farina Emanuele P. , Zwaan Martin A. , Decarli Roberto , Lusso Elisabeta 
Published: May 2022

Abstract
The systematic targeting of extended Lyα emission around high-redshift quasars resulted in the discovery of rare and bright Enormous Lyα Nebulae (ELANe) associated with multiple active galactic nuclei (AGNs). We initiate here “a multiwavelength study of ELAN environments” (AMUSE2) focusing on the ELAN around the z ∼ 3 quasar SDSS J1040+1020, aka the Fabulous ELAN. We report on VLT/HAWK-I, APEX/LABOCA, JCMT/SCUBA-2, SMA/850μm, and ALMA CO(5-4), and 2 mm observations and compare them to previously published VLT/MUSE data. The continuum and line detections enable a first estimate of the star formation rates, dust, stellar, and molecular gas masses in four objects associated with the ELAN (three AGNs and one Lyα emitter), confirming that the quasar host is the most star-forming (star formation rate of ∼500 M
⊙ yr−1) and massive galaxy (M
star ∼ 1011
M
⊙) in the system, and thus can be assumed as central. All four embedded objects have similar molecular gas reservoirs (

M

H

2

∼

10

10

M
⊙), resulting in short depletion timescales. This fact together with the estimated total dark matter halo mass, M
DM = (0.8–2) × 1013
M
⊙, imply that this ELAN will evolve into a giant elliptical galaxy. Consistently, the constraint on the baryonic mass budget for the whole system indicates that the majority of baryons should reside in a massive warm/hot reservoir (up to 1012
M
⊙), needed to complete the baryons count. Additionally, we discuss signatures of gas infall on the compact objects as traced by Lyα radiative transfer effects and the evidence for the alignment between the satellites’ spins and their directions to the central.