bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conditions for realizing one-point interactions from a multi-layer structure model
Authors: Zolotaryuk Alexander V , Zolotaryuk Yaroslav 
Published: January 2022

Abstract
A heterostructure composed of N parallel homogeneous layers is studied in the limit as their widths l
1, …, l

N
shrink to zero. The problem is investigated in one dimension and the piecewise constant potential in the Schrödinger equation is given by the strengths V
1, …, V

N
as functions of l
1, …, l

N
, respectively. The key point is the derivation of the conditions on the functions V
1(l
1), …, V

N
(l

N
) for realizing a family of one-point interactions as l
1, …, l

N
tend to zero along available paths in the N-dimensional space. The existence of equations for a squeezed structure, the solution of which determines the system parameter values, under which the non-zero tunneling of quantum particles through a multi-layer structure occurs, is shown to exist and depend on the paths. This tunneling appears as a result of an appropriate cancellation of divergences.
Raman spectra of twisted bilayer graphene close to the magic angle
Authors: Barbosa Tiago C , Gadelha Andreij C , Ohlberg Douglas A A , Watanabe Kenji , Taniguchi Takashi , Medeiros-Ribeiro Gilberto , Jorio Ado , Campos Leonardo C 
Published: January 2022

Abstract
In this work, we study the Raman spectra of twisted bilayer graphene samples as a function of their twist-angles (θ), ranging from 0.03° to 3.40°, where local θ are determined by analysis of their associated moiré superlattices, as imaged by scanning microwave impedance microscopy. Three standard excitation laser lines are used (457, 532, and 633 nm wavelengths), and the main Raman active graphene bands (G and 2D) are considered. Our results reveal that electron–phonon interaction influences the G band’s linewidth close to the magic angle regardless of laser excitation wavelength. Also, the 2D band lineshape in the θ < 1° regime is dictated by crystal lattice and depends on both the Bernal (AB and BA) stacking bilayer graphene and strain soliton regions (SP) (Gadelha et al 2021 Nature
590 405–9). We propose a geometrical model to explain the 2D lineshape variations, and from it, we estimate the SP width when moving towards the magic angle.
Fabrication of superhydrophilic surfaces for long time preservation on 316 l stainless steel by ultraviolet laser etching
Authors: Pan Chunyang , Xu Changfeng , Zhou Jun 
Published: January 2022

Abstract
Due to the good biocompatibility, 316 l stainless steel is widely used in the manufacture of medical instruments and human implants. The super hydrophilic 316 l steel surface is used for reducing friction and adhesion. By choosing appropriate laser process parameters 316 l steel surfaces with super-hydrophilic were obtained. The effects of laser process parameters including repeat frequency, pulse width, scanning speed, and the number of scanning were investigated to find the relationship between surface microstructure and wetting ability. To investigate the super-hydrophilic maintenance time on the textured surface, the textured surfaces were preserved in ambident air, distilled water, and absolute ethanol. The results showed that by choosing appropriate laser process parameters surface with super-hydrophilicity can be maintained for 30 d.
Intense green luminescence in Mn-doped gallogermanate nanostructured glass
Authors: Xu Xiaoyun , Xing Yingying , Yang Ziyue 
Published: January 2022

Abstract
Mn-activated optical materials have been demonstrated to be promising for various applications such as light-emitting device, tunable lasers and smart sensors. Most of the candidates belong to the single crystals and crystalline powders, and few reports involve about the glass-derived materials. This letter reports the fabrication of active Mn-doped nanostructured glass sample via control of the crystallization of a typical gallogermanate glass. LiGa5O8 and LiGaGeO4 can precipitate after heat-treatment, and Mn centers selectively incorporate into the crystalline phase. Importantly, the luminescence can be switched from red to green colour and the intensity can be enhanced simultaneously. Furthermore, the luminescence properties can be tuned via control of the phase of the nanostructured glass.
Choice and the Placebo Effect: A Meta-analysis
Authors: Tang Biya , Barnes Kirsten , Geers Andrew , Livesey Evan , Colagiuri Ben 
Published: January 2022

Abstract

Background
Choice has been proposed as a method of enhancing placebo effects. However, there have been no attempts to systematically evaluate the magnitude, reliability, and moderators of the influence of choice on the placebo effect.

Purpose
To estimate the effect size of choice on the placebo effect and identify any moderators of this effect.

Methods
Web of Science, PsycINFO, EMBASE, and PubMed were systematically searched from inception to May 2021 for studies comparing placebo treatment with any form of choice over its administration (e.g., type, timing) to placebo treatment without choice, on any health-related outcome. Random-effects meta-analysis was then used to estimate the effect size associated with the influence of choice on the placebo effect. Meta-regression was subsequently employed to determine the moderating effect of factors such as type of choice, frequency of choice, and size of the placebo effect without choice.

Results
Fifteen independent studies (N = 1,506) assessing a range of conditions, including pain, discomfort, sleep difficulty, and anxiety, met inclusion criteria. Meta-analysis revealed that choice did significantly enhance the placebo effect (Hedges’ g = 0.298). Size of the placebo effect without choice was the only reliable moderator of this effect, whereby a greater effect of choice was associated with smaller placebo effects without choice.

Conclusions
Treatment choice can effectively facilitate the placebo effect, but this effect appears more pronounced in contexts where the placebo effect without choice is weaker. Because most evidence to date is experimental, translational studies are needed to test whether providing choice in clinical scenarios where placebo effects are weaker may help boost the placebo effect and thereby improve patient outcomes.
Associations Between Parents’ Health and Social Control Behaviors and Their Adolescent’s Self-Efficacy and Health Behaviors: Insights From the Family Life, Activity, Sun, Health, and Eating (FLASHE) survey
Authors: Nakamura Monique S , Huelsnitz Chloe O , Rothman Alexander J , Simpson Jeffry A 
Published: January 2022

Abstract

Background
Parents can influence their children to live healthier lifestyles by modeling healthy behaviors and/or trying to persuade their children to engage in healthier activities. Adolescents and their parents tend to have similar eating and exercise patterns, but less is known about the simultaneous influence of parent’s health behavior and social control on adolescents’ self-efficacy and health behaviors, including whether their effect is moderated by parenting style.

Purpose
We examine the degree to which parents’ social control and health behaviors are associated with their adolescent’s self-efficacy and health behaviors, including whether parenting styles moderate these associations.

Method
We analyzed data from the Family Life, Activity, Sun, Health, and Eating project.

Results
We found that parents’ own health behaviors are positively and strongly associated with their adolescent’s health behaviors across four domains: fruit/vegetable consumption, junk food consumption, physical activity, and nonacademic screen time. We found positive, moderate-to-strong associations between parents’ use of social control and their adolescents’ fruit/vegetable and junk food consumption, small negative associations with screen time, and no associations with physical activity. The effects of social control for junk food consumption and screen time, however, depended on parents’ own behavior in those domains. Parent responsiveness moderated the relation between parents’ social control and their adolescent children’s self-efficacy and health behaviors.

Conclusions
The health behaviors parents model and their social control efforts are associated with their adolescents’ beliefs and behavior. Efforts to leverage parents as sources of influence must consider the context in which influence is enacted.
Fiction and Epistemic Value: State of the Art
Authors: Green Mitchell 
Published: January 2022

AbstractWe critically survey prominent recent scholarship on the question of whether fiction can be a source of epistemic value for those who engage with it fully and appropriately. Such epistemic value might take the form of knowledge (for ‘cognitivists’) or understanding (for ‘neo-cognitivists’). Both camps may be sorted according to a further distinction between views explaining fiction’s epistemic value either in terms of the author’s engaging in a form of telling, or instead via their showing some state of affairs to obtain, a special case of which is the provision of self-knowledge. Fictional works that show rather than tell often employ thought experiments. The epistemic value of some fictional works is indicated by their enabling of empathy, itself illuminated via the psychological process of experience-taking. Whether a fictional work offers epistemic value by telling or showing, there is, in principle, no bar to its being able to deliver on what it offers, and consumers of fiction who exercise epistemic vigilance may gain either knowledge or some degree of understanding from their engagement with it.
Analysis of MicroRNA in Bile Cytologic Samples Is Useful for Detection and Diagnosis of Extrahepatic Cholangiocarcinoma
Authors: Uchihata Yukari , Arihiro Koji , Kaneko Yoshie , Shimizu Tomomi , Marubashi Yukari , Aoki Chie , Murakami Takuya , Ochi Mayu , Niihara Nanaka , Ohtsuka Kohei , Unehara Rimu , Araki Yusuke , Seki Yoshinaga , Mori Keiichi , Oda Miyo , Ishida Katsunari 
Published: January 2022

Abstract

Objectives
This study aimed to develop reliable biomarkers that improve the ability of bile cytology to diagnose cholangiocarcinoma vs benign biliary lesions.

Methods
Many studies indicate that microRNAs (miRNAs) are potential candidates for the early diagnosis of cancer. We analyzed the expression of five tumor-associated miRNAs (miR-31-5p, miR-122-5p, miR-378d, miR-182-5p, and miR-92a-3p) in cytology samples using quantitative reverse transcription polymerase chain reaction. We collected 52 surgically resected tissue samples, 84 cytologic specimens from smears (53 cases of cancer and 31 cases of noncancer), and 40 residual sediments after smearing for routine cytology at Hiroshima University Hospital.

Results
The expression of miR-31-5p, miR-378d, and miR-122-5p was significantly higher in cancer tissues than those in normal tissues, while miR-182-5p expression was lower. The expression of miR-31-5p, miR-378d, miR-182-5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases.

Conclusions
These results suggest that the analysis of miRNAs in bile cytologic specimens is a promising auxiliary tool for distinguishing cholangiocarcinoma from benign biliary lesions.
A novel milk-clotting enzyme from Aspergillus oryzae and A. luchuensis is an aspartic endopeptidase PepE presumed to be a vacuolar enzyme
Authors: Takyu Yoko , Asamura Taro , Okamoto Ayako , Maeda Hiroshi , Takeuchi Michio , Kusumoto Ken-Ich , Katase Toru , Ishida Hiroki , Tanaka Mizuki , Yamagata Youhei 
Published: January 2022

ABSTRACT
Aspergillus oryzae RIB40 has 11 aspartic endopeptidase genes. We searched for milk-clotting enzymes based on the homology of the deduced amino acid sequence with chymosins. As a result, we identified a milk-clotting enzyme in A. oryzae. We expected other Aspergillus species to have a homologous enzyme with milk-clotting activity, and we found the most homologous aspartic endopeptidase from A. luchuensis had milk-clotting activity. Surprisingly, 2 enzymes were considered as vacuole enzymes according to a study on A. niger proteases. The 2 enzymes from A. oryzae and A. luchuensis cleaved a peptide between the 105Phe-106Met bond in κ-casein, similar to chymosin. Although both enzymes showed proteolytic activity using casein as a substrate, the optimum pH values for milk-clotting and proteolytic activities were different. Furthermore, the substrate specificities were highly restricted. Therefore, we expected that the Japanese traditional fermentation agent, koji, could be used as an enzyme source for cheese production.
ViruClust: direct comparison of SARS-CoV-2 genomes and genetic variants in space and time
Authors: Cilibrasi Luca , Pinoli Pietro , Bernasconi Anna , Canakoglu Arif , Chiara Matteo , Ceri Stefano 
Published: January 2022

Abstract

Motivation
The ongoing evolution of SARS-CoV-2 and the rapid emergence of variants of concern at distinct geographic locations have relevant implications for the implementation of strategies for controlling the COVID-19 pandemic. Combining the growing body of data and the evidence on potential functional implications of SARS-CoV-2 mutations can suggest highly effective methods for the prioritization of novel variants of potential concern, e.g. increasing in frequency locally and/or globally. However, these analyses may be complex, requiring the integration of different data and resources. We claim the need for a streamlined access to up-to-date and high-quality genome sequencing data from different geographic regions/countries, and the current lack of a robust and consistent framework for the evaluation/comparison of the results.

Results
To overcome these limitations, we developed ViruClust, a novel tool for the comparison of SARS-CoV-2 genomic sequences and lineages in space and time. ViruClust is made available through a powerful and intuitive web-based user interface. Sophisticated large-scale analyses can be executed with a few clicks, even by users without any computational background. To demonstrate potential applications of our method, we applied ViruClust to conduct a thorough study of the evolution of the most prevalent lineage of the Delta SARS-CoV-2 variant, and derived relevant observations. By allowing the seamless integration of different types of functional annotations and the direct comparison of viral genomes and genetic variants in space and time, ViruClust represents a highly valuable resource for monitoring the evolution of SARS-CoV-2, facilitating the identification of variants and/or mutations of potential concern.

Availability and implementation
ViruClust is openly available at http://gmql.eu/viruclust/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Environmental Influences on Life Satisfaction and Depressive Symptoms Among Older Adults With Multimorbidity: Path Analysis Through Loneliness in the Canadian Longitudinal Study on Aging
Authors: Gan Daniel R Y , Wister Andrew V , Best John R 
Published: January 2022

AbstractBackground and ObjectivesMore older adults with multimorbidity are aging in place than ever before. Knowing how the environment affects their mental well-being could enhance the efficacy of age-friendly interventions for multimorbidity resilience. With reference to the Transdisciplinary Neighborhood Health Framework, we construct and examine a priori models of environmental influences on life satisfaction and depressive symptoms.Research Design and MethodsBaseline and follow-up data (after 3 years) were drawn from the Canadian Longitudinal Study on Aging to identify a subsample (n = 14,301) of participants aged at least 65 years with at least 2 chronic diseases. Path analysis examined sociobehavioral attributes (i.e., social support, social participation, walking) and loneliness as primary and secondary mediators, controlling for age, sex, education, and outcomes during baseline.ResultsGood model fit was found (TFI = 1.00; CFI = 1.00; RMSEA &lt; 0.001; SRMR &lt; 0.001). The total effects of housing quality (rtotal = 0.08, −0.07) and neighborhood cohesion (rtotal = 0.03, −0.06) were weak but statistically significant in the expected direction. The mediators explained 21%–31% of the total effects of housing quality and 67%–100% of the total effects of neighborhood cohesion. Loneliness mediated 27%–29% of these environmental influences on mental well-being, whereas walking mediated a mere 0.4%–0.9% of the total effects. Walking did not explain the relationship between housing quality and mental well-being.Discussion and ImplicationsData supported a priori pathways from environment to mental well-being through sociobehavioral attributes and loneliness. If these pathways from neighborhood cohesion to life satisfaction reflect causal effects, community-based age-friendly interventions should focus on enhancing neighborhood cohesion to mitigate loneliness among multimorbid older adults for their mental well-being.
The Retention of Older Employees and Core Work Activities: Evidence From Denmark
Authors: Qvist Jeevitha Yogachandiran , Jensen Per H 
Published: January 2022

AbstractBackground and ObjectivesRetention of older employees in the labor market is crucial to cope with aging populations. Retention of older employees can appear in different forms, such as phased retirement, bridge jobs, career development, or health promotion. However, little is known about how the offering of these retention strategies may vary across workplaces with different core work activities because the opportunities to implement different types of retention strategies are preconditioned by differences in the economic and labor market climate.Research Design and MethodsThe study utilizes data from a survey conducted among Danish workplaces in 2018, which is linked to administrative register data to conduct Karlson-Holm-Breen-corrected logistic regression models. The study distinguishes among production workplaces, service and welfare workplaces, and information workplaces.ResultsPhased retirement is most prevalent in service and welfare workplaces, whereas job bridging is most prevalent in both service and welfare and production workplaces. Career development and health promotion strategies are least prevalent in production workplaces. These retention differences between workplaces with different core work activities are in most cases explained by differences in trade union influence, physical working demands, and knowledge intensity.Discussion and ImplicationsAlthough the type of retention strategy offered in the workplace largely matches the core work activity within the workplace, particularly production workplaces could feasibly take more advantage of using career development or health promotion strategies because the employees of these workplaces are more likely to retire early due to poor health and physical working conditions.
Chromosome-level genome assembly of the shuttles hoppfish, Periophthalmus modestus
Authors: Yang Youngik , Yoo Ji Yong , Baek Sang Ho , Song Ha Yeun , Jo Seonmi , Jung Seung-Hyun , Choi Jeong-Hyeon 
Published: January 2022

Abstract

Background
The shuttles hoppfish (mudskipper), Periophthalmus modestus, is one of the mudskippers, which are the largest group of amphibious teleost fishes, which are uniquely adapted to live on mudflats. Because mudskippers can survive on land for extended periods by breathing through their skin and through the lining of the mouth and throat, they were evaluated as a model for the evolutionary sea-land transition of Devonian protoamphibians, ancestors of all present tetrapods.

Results
A total of 39.6, 80.2, 52.9, and 33.3 Gb of Illumina, Pacific Biosciences, 10X linked, and Hi-C data, respectively, was assembled into 1,419 scaffolds with an N50 length of 33 Mb and BUSCO score of 96.6%. The assembly covered 117% of the estimated genome size (729 Mb) and included 23 pseudo-chromosomes anchored by a Hi-C contact map, which corresponded to the top 23 longest scaffolds above 20 Mb and close to the estimated one. Of the genome, 43.8% were various repetitive elements such as DNAs, tandem repeats, long interspersed nuclear elements, and simple repeats. Ab initio and homology-based gene prediction identified 30,505 genes, of which 94% had homology to the 14 Actinopterygii transcriptomes and 89% and 85% to Pfam familes and InterPro domains, respectively. Comparative genomics with 15 Actinopterygii species identified 59,448 gene families of which 12% were only in P. modestus.

Conclusions
We present the high quality of the first genome assembly and gene annotation of the shuttles hoppfish. It will provide a valuable resource for further studies on sea-land transition, bimodal respiration, nitrogen excretion, osmoregulation, thermoregulation, vision, and mechanoreception.
Inferring microbiota functions from taxonomic genes: a review
Authors: Djemiel Christophe , Maron Pierre-Alain , Terrat Sébastien , Dequiedt Samuel , Cottin Aurélien , Ranjard Lionel 
Published: January 2022

Abstract
Deciphering microbiota functions is crucial to predict ecosystem sustainability in response to global change. High-throughput sequencing at the individual or community level has revolutionized our understanding of microbial ecology, leading to the big data era and improving our ability to link microbial diversity with microbial functions. Recent advances in bioinformatics have been key for developing functional prediction tools based on DNA metabarcoding data and using taxonomic gene information. This cheaper approach in every aspect serves as an alternative to shotgun sequencing. Although these tools are increasingly used by ecologists, an objective evaluation of their modularity, portability, and robustness is lacking. Here, we reviewed 100 scientific papers on functional inference and ecological trait assignment to rank the advantages, specificities, and drawbacks of these tools, using a scientific benchmarking. To date, inference tools have been mainly devoted to bacterial functions, and ecological trait assignment tools, to fungal functions. A major limitation is the lack of reference genomes—compared with the human microbiota—especially for complex ecosystems such as soils. Finally, we explore applied research prospects. These tools are promising and already provide relevant information on ecosystem functioning, but standardized indicators and corresponding repositories are still lacking that would enable them to be used for operational diagnosis.
Transapical combined transcatheter aortic valve-in-valve implant and ascending aorta endovascular repair
Authors: Agostinelli Andrea , Gallingani Alan , Borrello Bruno , Nicolini Francesco 
Published: January 2022

Abstract
We report the case of a 64-year-old patient who previously had an aortic valve replacement with a stentless aortic valve and an ascending aorta replacement for a DeBakey type II aortic dissection. The patient was referred to us for symptomatic aortic regurgitation related to bioprosthesis degeneration and a pseudoaneurysm at the distal anastomotic site of the vascular graft. Due to the presence of several comorbidities, the patient had a combined transapical transcatheter aortic valve-in-valve implant and an ascending aorta endovascular repair.