bluuebunny/crossref_metadata_2025_split huggingface dataset:
LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis
Authors: Hyodo Toshinori , Asano-Inami Eri , Ito Satoko , Sugiyama Mai , Nawa Akihiro , Rahman Md. Lutfur , Hasan Muhammad Nazmul , Mihara Yuko , Lam Vu Quang , Karnan Sivasundaram , Ota Akinobu , Tsuzuki Shinobu , Hamaguchi Michinari , Hosokawa Yoshitaka , Konishi Hiroyuki 
Published: July 2022

AbstractThere has been a great deal of research on cell division and its mechanisms; however, its processes have not yet been entirely elucidated. To find novel proteins that regulate cell division, we performed the screening using siRNAs and/or the expression plasmid of the target genes and identified leucine zipper protein 1 (LUZP1). Recent studies have shown that LUZP1 interacts with various proteins and stabilizes the actin cytoskeleton; however, the function of LUZP1 in mitosis is not known. In this study, we found that LUZP1 colocalized with the chromosomal passenger complex (CPC) at the centromere in metaphase and at the central spindle in anaphase and that these LUZP1 localizations were regulated by CPC activity and kinesin family member 20A (KIF20A). Mass spectrometry analysis identified that LUZP1 interacted with death-associated protein kinase 3 (DAPK3), one regulator of the cleavage furrow ingression in cytokinesis. In addition, we found that LUZP1 also interacted with myosin light chain 9 (MYL9), a substrate of DAPK3, and comprehensively inhibited MYL9 phosphorylation by DAPK3. In line with a known role for MYL9 in the actin-myosin contraction, LUZP1 suppression accelerated the constriction velocity at the division plane in our timelapse analysis. Our study indicates that LUZP1 is a novel regulator for cytokinesis that regulates the constriction velocity of the contractile ring.
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation
Authors: Juyoux Pauline , Galdadas Ioannis , Gobbo Dorothea , Velsen Jill von , Pelosse Martin , Tully Mark , Vadas Oscar , Gervasio Francesco Luigi , Pellegrini Erika , Bowler Matthew W. 
Published: July 2022

AbstractThe MAP kinase p38α is a central component of signalling in inflammation and the immune response and is, therefore, an important drug target. Little is known about the molecular mechanism of its activation by double-phosphorylation from MAP2Ks, due to the challenge of trapping a transient and dynamic hetero-kinase complex. Here, we applied a multidisciplinary approach to generate the first structure of p38α in complex with its MAP2K MKK6 and understand the activation mechanism. Integrating cryo-EM with MD simulations, HDX-MS andin celluloexperiments, we demonstrate a dynamic, multi-step, phosphorylation mechanism, reveal new catalytically relevant interactions, and show that MAP2K disordered N-termini determine pathway specificity. Our work captures, for the first time, a fundamental step of cell signalling: a kinase phosphorylating its downstream target kinase.One-Sentence SummaryIntegrative Cryo-EM and MD analysis of an active hetero-kinase complex reveals details of cellular signal transmission
Conceptualizing and theorizing green human resource management: a narrative review
Authors: Mukherji Anuradha , Bhatnagar Jyotsna 
Published: July 2022

PurposeThe study reviews the recent conceptualizations and theorizing of green human resource management (GHRM) and explores GHRM's interconnections with the sustainability literature. The research findings have implications affecting GHRM measurement and design of future studies in the sparsely investigated human resource management (HRM)-environment-sustainability-responsibility spectrum.Design/methodology/approachThe study uses a narrative style based on a review of quantitative field evidence from 38 recent empirical papers to provide an analytical framework on how the GHRM research agenda has broadened to include aspects of corporate sustainability (CS) and corporate social responsibility (CSR).FindingsThe study finds support from the literature on the impact of environment-related HR initiatives on building long-term capabilities and enhancing firm-specific social outcomes. Further, the study finds that different perspectives used in the conceptualization of GHRM reveal GHRM's differential impact on organization and environmental sustainability underlying GHRM's growing recognition as an important tool for organizations to demonstrate their commitment to being a responsible stakeholder of the socio-economic system.Originality/valueGHRM scholars would find the review useful as the review provides a detailed explanation of how GHRM problems are defined and measured. The understanding of the process of conceptualization has been identified as a research gap in previous reviews; thus, one of the aims of this paper is to aid further knowledge development by understanding how research has progressed previously. The other benefit of the review is that management practitioners would find the insights useful to align HRM initiatives with organization CS/CSR objectives.
Building corporate reputation through corporate social responsibility: the mediation role of employer branding
Authors: Binu Raj Asha , N. Akbar Jan , A.K. Subramani 
Published: July 2022

PurposeThe paper analyses the link between corporate social responsibility (CSR), employer branding (EB), and corporate reputation (CR). Considering the signaling theory and social commitment of organisations, the paper investigates the role of EB as a mediator.Design/methodology/approachData were collected through structured questionnaires from 684 employees from the Indian information technology (IT) sector. The conceptual model and hypotheses were tested using the structural equation modelling (SEM) approach.FindingsAs a part of employer attractiveness, the social value/social commitment of companies perceived as a result of CSR strengthens the CR. The results also suggest that EB mediates the relation between CSR and CR.Research limitations/implicationsThe paper contributes by integrating the CSR of organisations with their EB process for creating CR. Based on signaling theory, it further demonstrates scholarly value addition by providing a deeper understanding of the mediation effect of EB from a social commitment perspective. Scholars may further consider other stakeholders’ perspectives to test the role of CSR based on ethical/legal/environmental dimensions in building CR.Practical implicationsThe paper would help managers/employers invest in CSR activities, creating strong employer brands to attract various stakeholders. It will also help companies to focus on an attractive value proposition to attract various stakeholders, mainly job seekers.Originality/valueThis study extends the literature on CSR and EB by suggesting a statistically tested model of mediation of EB for creating CR. Furthermore, considering the signaling theory, the paper views CSR, CR, and EB from the employee’s perspective and explores their linkages.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2021-0541.
Analysis of rice production and the impacts of the usage of certified seeds on yield and income in Côte d'Ivoire
Authors: Akanbi Sheu-Usman Oladipo , Mukaila Ridwan , Adebisi Abdourasaque 
Published: July 2022

PurposeAfter a long observation of the high rate of rice importation and low productivity in Côte d’Ivoire, the certified rice seed was introduced and encouraged to be used by the local farmers. This study evaluates the profitability of rice production and the impact of certified seed usage on the yield and income of farmers in Côte d’Ivoire.Design/methodology/approachData were collected from 265 rice farmers. Descriptive statistics were used to identify the challenges faced in using certified seeds. Profitability analysis was used to examine the profitability of rice production. To eliminate bias due to the counterfactuals, the endogenous switching regression was employed to investigate the impact of the certified seeds on income and yield.FindingsThe difficulties faced by the rice farmers in the procurement of certified seeds were the unavailability of seeds, the high cost of seeds and poor credit access. Furthermore, rice farmers using certified seeds get a higher net income (USD 263.74/ha) than those using farmers' seeds (USD 212.31/ha). The average treatment on the treated was 1.61 for the yield and 574.75 for the income. The average treatment on the untreated was 1.20 for the yield and 422.59 for the income. These indicate a higher yield and income among adopters of certified rice seed.Research limitations/implicationsCertified rice seed usage is profitable and enhances the output and income of rice farmers. The study advocates the creation of a stronger relationship between the farmers and the extension agents to encourage the use of certified seeds and increase the profit of the farmers.Originality/valueThere is scant information on the profitability of certified rice seed usage and how it affect yield and income. Therefore, this study serves as empirical evidence for policymakers to develop strategies that are required to enhance certified seed usage, boost rice productivity and achieve food security.
Critical aspects of entrepreneurship policy design for Syrian refugees in Turkey
Authors: Kassab Ammar , Omar Rosmini , Ghura Hasan 
Published: July 2022

PurposeGovernments can influence entrepreneurial growth through public policy. This paper aims to present critical aspects of entrepreneurship policy design for Syrian refugees in Turkey and evaluate if current policies are effective for Syrian refugees in Istanbul.Design/methodology/approachThe study adopts an explorative phenomenological approach, contextualized within the entrepreneurial behavior literature. The data was collected through semi-structured interviews with fifteen Syrian entrepreneurs residing in Istanbul.FindingsThe results show that Syrian refugees were “pushed” to start new companies. Moreover, the findings suggest that Syrian entrepreneurs could exploit better business opportunities such as targeting international markets or finding competent partners.Research limitations/implicationsThe article offers several practical and social contributions by highlighting how the entrepreneurial behavior of Syrian refugees is driven by their migration or business experiences.Practical implicationsPolicymakers in Turkey need to acknowledge how their entrepreneurial policies regarding innovation and internationalization affect the business success rate among Syrian refugees. In this regard, the Turkish government should adopt new measures that provide Syrian refugees more business flexibility. These policies may include easy access to the Turkish financial system or fewer regulations to obtain work permits. This will encourage refugees to join the formal economy and contribute to the Turkish labor market.Originality/valueThis article adds to the expanding body of knowledge on refugee entrepreneurship by emphasizing the link between refugees' personal experiences and starting new ventures. It also highlights how government policy can be strategically utilized to increase entrepreneurship among Syrian refugees in Turkey.
Building resilience during the Covid-19 pandemic: the journey of a small entrepreneurial family firm in Brazil
Authors: Amaral Priscila Correa Franco , Da Rocha Angela 
Published: July 2022

PurposeThe present study used a process approach to examine how a small entrepreneurial family business in the tourism industry evolved during different stages of the Covid-19 pandemic and across different dimensions of resilience.Design/methodology/approachThe research strategy consisted of a real-time longitudinal case study during the Covid-19 pandemic in Brazil, based on interviews conducted with the founders of the business.FindingsThe results show how the firm responded to the pandemic and moved through different stages – interruption, loss, resumption, and recovery – as the crisis evolved. During each stage, there were manifestations of different dimensions of organizational resilience: anticipation/awareness, coping and adaptation. The entrepreneurs mobilized several capabilities – emotional, cognitive, behavioral, and relational – during the different stages and across different dimensions to face and respond to the pandemic.Originality/valueThe contributions of the study stem from the lack of research on how small entrepreneurial family businesses in the tourism industry are impacted by disruptive events of long duration and multiple cycles. Specifically, the study contributes to the understanding of how this type of firm responds to these crises, mobilizing different capabilities at different stages and across different dimensions of organizational resilience.
Role of academic libraries in the achievement of quality education as a sustainable development goal
Authors: Dei De-Graft Johnson , Asante Francisca Yaba 
Published: July 2022

PurposeThis study explored the role of academic libraries in the achievement of quality education as a Sustainable Development Goal.Design/methodology/approachThe study adopted a qualitative research approach and descriptive case study design. This study focuses on academic libraries from four universities in Ghana. From each university, the researchers purposely selected four respondents, comprising the heads of the libraries, deputies, and two assistant librarians or library assistants. Primary data were collected through semi-structured interviews, observations and document reviews. The results were analyzed and presented in descriptive and interpretive forms.FindingsThe study established that the majority of the library staff were aware of the sustainable development goal, SDG 4. The libraries provided relevant materials to support students’ learning, organize training on information literacy and engage library patrons in periodic information literacy programs to create awareness of the SDG 4. Since the libraries do not have their own internally developed policies on the SDG 4, they depend on the general United Nations (UN) document on the SDG and SDG 4 as a guide in information delivery; and the general policies on information delivery, teaching and quality assurance of the universities in general and the libraries in particular. The study concluded with a framework to guide the successful accomplishment of the SDG 4 in libraries.Research limitations/implicationsThe study focused on academic libraries in Ghana and adopted the purposive sampling technique which makes it assume a weak power of generalization.Practical implicationsThe study has implications for academic libraries and librarians in Ghana in achieving the SDG 4. It will guide librarians and academic libraries in formulating policies to guide them in their activities. The framework developed as a result of the findings will equally guide the librarians in their quest to provide information to achieve the SDG 4.Originality/valueThis study's originality lies in its articulation of academic libraries' initiatives in the actualization of the SDG 4 in Ghana with a developed framework to guide librarians and academic libraries. Academic libraries and librarians who are eager to contribute their quota to the achievement of the SDG 4 will find this study useful.
Bite force in the strictly subterranean rodent family of African mole‐rats (Bathyergidae): The role of digging mode, social organization and ecology
Authors: Kraus Andrea , Lövy Matěj , Mikula Ondřej , Okrouhlík Jan , Bennett Nigel C. , Herrel Anthony , Šumbera Radim 
Published: July 2022

AbstractBite force is an ecologically relevant performance trait that has been measured to better understand the adaptations to diet and habitat use. Moreover, bite force is relevant in understanding reproductive success, as well as inter‐ and intraspecific competition.African mole‐rats (Bathyergidae, Rodentia) are a unique clade of mammals that use different digging strategies, show different types of social organization and occur in ecologically diverse savanna habitats in sub‐Saharan Africa. Whereas previous studies have suggested these animals have exceptionally high bite forces, the ecological and other proximate and ultimate drivers of variation in bite force in the group remain unstudied.In the present study we measured in vivo bite force of 394 adult specimens from 10 African mole‐rat species including all genera within the family.Our results show that in African mole‐rats digging mode is a major driver of variation in bite force, with chisel‐tooth diggers being stronger biters than scratch diggers. Moreover, species living in habitats characterized by low and irregular precipitation patterns and in soils with a high content of coarse particles have a higher bite force than species occupying habitats with a regular rainfall pattern and fine soil types.This suggests that bite force in bathyergids has evolved in concert with rainfall and soil characteristics of different savanna habitats, which have contributed to the successful radiation of these subterranean mammals across sub‐Saharan Africa.Read the freePlain Language Summaryfor this article on the Journal blog.
Efficacy and safety of eptinezumab as preventive treatment for episodic/chronic migraine: A systematic review and meta‐analysis
Authors: Siahaan Yusak Mangara Tua , Hartoyo Vinson , Hariyanto Timotius Ivan 
Published: July 2022

AbstractMigraine, the third most common neurological disorders worldwide, can cause significant burden to the patients. Currently, it has been found that calcitonin gene‐related peptide (CGRP) has a significant role in pathophysiology of migraine. This study sought to analyse the efficacy and safety of eptinezumab, one of the CGRP‐monoclonal antibody as preventive treatment for episodic/chronic migraine. Specific keywords were used to comprehensively go through the potential articles on ClinicalTrials.gov, Europe PMC, Scopus and PubMed databases until April 2022. All published randomized clinical trials (RCTs) on eptinezumab and migraine were gathered. Statistical analysis was conducted by using Review Manager 5.4 and Comprehensive Meta‐Analysis version 3 software. There were four RCTs with 2739 migraine patients in the meta‐analysis. In terms of efficacy, our analysis revealed that eptinezumab corresponded with higher reduction in monthly migraine days from baseline to week 12 (standardized mean difference, −0.34 [95% confidence interval (CI), −0.41, −0.28], P < 0.00001; I2 = 0%), higher 75% and 50% migraine responder rate, reduction in rate of migraine on day‐1 after dosing, lower headache impact test‐6 score on week 4 and week 12. In terms of safety, eptinezumab has comparable adverse events when compared with placebo (risk ratio, 1.01 [95% CI 0.96–1.07], P = 0.63, I2 = 0%). Further regression analysis also revealed that the association between eptinezumab and each outcomes of interest were not influenced by age, gender, body mass index and duration of migraine. This study proposes that eptinezumab is generally effective and safe for the preventive treatment of episodic or chronic migraine.
Randomised trial of population‐based BRCA testing in Ashkenazi Jews: long‐term secondary lifestyle behavioural outcomes
Authors: Burnell Matthew , Gaba Faiza , Sobocan Monika , Desai Rakshit , Sanderson Saskia , Loggenberg Kelly , Gessler Sue , Side Lucy , Brady Angela F. , Dorkins Huw , Wallis Yvonne , Jacobs Chris , Legood Rosa , Beller Uziel , Tomlinson Ian , Wardle Jane , Menon Usha , Jacobs Ian , Manchanda Ranjit 
Published: July 2022

AbstractObjectiveAshkenazi‐Jewish (AJ) population‐based BRCA testing is acceptable, cost‐effective and amplifies primary prevention for breast & ovarian cancer. However, data describing lifestyle impact are lacking. We report long‐term results of population‐based BRCA testing on lifestyle behaviour and cancer risk perception.DesignTwo‐arm randomised controlled trials (ISRCTN73338115, GCaPPS): (a) population‐screening (PS); (b) family history (FH)/clinical criteria testing.SettingNorth London AJ‐population.Population/SampleAJ women/men >18 years. Exclusions: prior BRCA testing or first‐degree relatives of BRCA‐carriers.MethodsParticipants were recruited through self‐referral. All participants received informed pre‐test genetic counselling. The intervention included genetic testing for three AJ BRCA‐mutations: 185delAG(c.68_69delAG), 5382insC(c.5266dupC) and 6174delT(c.5946delT). This was undertaken for all participants in the PS arm and participants fulfilling FH/clinical criteria in the FH arm. Patients filled out customised/validated questionnaires at baseline/1‐year/2‐year/3‐year follow‐ups. Generalised linear‐mixed models adjusted for covariates and appropriate contrast tests were used for between‐group/within‐group analysis of lifestyle and behavioural outcomes along with evaluating factors associated with these outcomes. Outcomes are adjusted for multiple testing (Bonferroni method), with P < 0.0039 considered significant.Outcome measuresLifestyle/behavioural outcomes at baseline/1‐year/2‐year/3‐year follow‐ups.Results1034 participants were randomised to PS (n = 530) or FH (n = 504) arms. No significant difference was identified between PS‐ and FH‐based BRCA testing approaches in terms of dietary fruit/vegetable/meat consumption, vitamin intake, alcohol quantity/ frequency, smoking behaviour (frequency/cessation), physical activity/exercise or routine breast mammogram screening behaviour, with outcomes not affected by BRCA test result. Cancer risk perception decreased with time following BRCA testing, with no difference between FH/PS approaches, and the perception of risk was lowest in BRCA‐negative participants. Men consumed fewer fruits/vegetables/vitamins and more meat/alcohol than women (P < 0.001).ConclusionPopulation‐based and FH‐based AJ BRCA testing have similar long‐term lifestyle impacts on smoking, alcohol, dietary fruit/vegetable/meat/vitamin, exercise, breast screening participation and reduced cancer risk perception.
Hernia in pregnancy—Does it matter?
Authors: Chiu Hon Yiu , Law Tsz Ting , Ng Lily , Wong Kin Yuen 
Published: July 2022

AbstractIntroductionPregnancy is a risk factor for hernia development. This review studies the natural history and outcomes of hernias in pregnant women treated in the Hong Kong West Cluster.MethodsThis is a cluster‐wide, retrospective descriptive study. Electronic medical records of women attending Hernia Clinics at Tung Wah Hospital or Queen Mary Hospital or those emergently admitted into the surgical department between January 2002 and January 2022 were screened. Inclusion criteria were women with: (i) hernia developed during pregnancy; and (ii) known unrepaired hernia developed prior to pregnancy.ResultsForty‐one patients were included. Median age of hernia onset was 31 years old. All patients continued with pregnancy with no hernia complications. None received hernia repair before delivery. Nine out of 41 patients (22.0%) received Caesarean section. Fourteen out of 22 (63.6%) patients with inguinal hernias developed during pregnancy reported hernia disappearance after delivery, of whom five experienced hernia recurrence. One out of five patients with ventral hernia developed during pregnancy experienced hernia disappearance after delivery with no recurrence. 43.9% received hernia repair after delivery.ConclusionsIt is safe to adopt conservative management in pregnant women. Vaginal delivery is not contraindicated. We recommend watchful waiting during pregnancy and repair after delivery.