bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Survey of Use and Ownership Rights in Finnmark – A Change of Direction?
Authors: Ravna Øyvind 
Published: January 2022

Abstract
In 2008, the Finnmark Act initiated a process of surveying land rights the Sámi and others may have in Finnmark, the core Sámi area of Norway. The Finnmark Commission, which was established to conduct the survey has completed six investigations. The assessments and conclusions in the first five reports are so similar in terms of collective rights appears as cut from the same cloth. In December 2019, the Commission presented its sixth report, which covers the municipality of Karasjok, a community with a Sámi majority. This report marks a significant change from the previous ones, as the Commission for the first time concludes that the people in an investigation field own their outlying areas. This article examines how the Commission arrived at that result, pointing out that it is more an outcome of a different approach to the legal history and international law, than substantive differences in factual circumstances.
The Jewish Reception of Aristotle’s Poetics in Thirteenth- and Fourteenth-century Provence: A Survey of the Arabic Sources
Authors: Gorgoni Francesca 
Published: January 2022

Abstract
The last few years have seen a renewed interest in Aristotle’s logic in the Jewish tradition, giving a decisive impulse to the research on the Greek-into-Hebrew philosophical transmission in medieval and early modern times. The present article aims to contribute to the studies on Aristotelian logic in Hebrew by focusing on a less explored aspect, namely the reception of Aristotle’s Poetics in Jewish culture.
Spatiotemporal Modeling of the Wind Field over an Urban Lake Subject to Wind Sheltering
Authors: Ashrafi Mohammad , Chua Lloyd H. C. , Irvine K. N. , Yang Peipei 
Published: January 2022

Abstract
The wind field over an urban lake may exhibit considerable variability resulting from wind-shielding effects from surrounding structures. Field measurements at an urban reservoir in Singapore were augmented by computational fluid dynamics (CFD) model results to develop a wind model over the reservoir surface via a data assimilation approach. The field measurements identified, depending on structure alignment with the prevailing wind direction, wind shielding that impacted wind direction and velocity over the reservoir surface. The wind model integrated the temporal response of the measurements and spatial distribution produced by the CFD modeling. The wind model was used to predict the spatiotemporal pattern of the wind field over the reservoir surface for a full year. The modeling results showed good agreement with measured wind data at three measurement locations on the reservoir surface. The wind model has been incorporated with a hydrodynamics and water quality model to provide the spatiotemporal wind forcing over the reservoir surface.
Observed and Modeled Mountain Waves from the Surface to the Mesosphere near the Drake Passage
Authors: Kruse Christopher G. , Alexander M. Joan , Hoffmann Lars , van Niekerk Annelize , Polichtchouk Inna , Bacmeister Julio T. , Holt Laura , Plougonven Riwal , Šácha Petr , Wright Corwin , Sato Kaoru , Shibuya Ryosuke , Gisinger Sonja , Ern Manfred , Meyer Catrin I. , Stein Olaf 
Published: January 2022

Abstract
Four state-of-the-science numerical weather prediction (NWP) models were used to perform mountain wave (MW)-resolving hindcasts over the Drake Passage of a 10-day period in 2010 with numerous observed MW cases. The Integrated Forecast System (IFS) and the Icosahedral Nonhydrostatic (ICON) model were run at Δx ≈ 9 and 13 km globally. The Weather Research and Forecasting (WRF) Model and the Met Office Unified Model (UM) were both configured with a Δx = 3-km regional domain. All domains had tops near 1 Pa (z ≈ 80 km). These deep domains allowed quantitative validation against Atmospheric Infrared Sounder (AIRS) observations, accounting for observation time, viewing geometry, and radiative transfer. All models reproduced observed middle-atmosphere MWs with remarkable skill. Increased horizontal resolution improved validations. Still, all models underrepresented observed MW amplitudes, even after accounting for model effective resolution and instrument noise, suggesting even at Δx ≈ 3-km resolution, small-scale MWs are underresolved and/or overdiffused. MW drag parameterizations are still necessary in NWP models at current operational resolutions of Δx ≈ 10 km. Upper GW sponge layers in the operationally configured models significantly, artificially reduced MW amplitudes in the upper stratosphere and mesosphere. In the IFS, parameterized GW drags partly compensated this deficiency, but still, total drags were ≈6 times smaller than that resolved at Δx ≈ 3 km. Meridionally propagating MWs significantly enhance zonal drag over the Drake Passage. Interestingly, drag associated with meridional fluxes of zonal momentum (i.e.,
) were important; not accounting for these terms results in a drag in the wrong direction at and below the polar night jet.

Significance Statement
This study had three purposes: to quantitatively evaluate how well four state-of-the-science weather models could reproduce observed mountain waves (MWs) in the middle atmosphere, to compare the simulated MWs within the models, and to quantitatively evaluate two MW parameterizations in a widely used climate model. These models reproduced observed MWs with remarkable skill. Still, MW parameterizations are necessary in current Δx ≈ 10-km resolution global weather models. Even Δx ≈ 3-km resolution does not appear to be high enough to represent all momentum-fluxing MW scales. Meridionally propagating MWs can significantly influence zonal winds over the Drake Passage. Parameterizations that handle horizontal propagation may need to consider horizontal fluxes of horizontal momentum in order to get the direction of their forcing correct.
Clinicopathological Features Related to the Efficacy of CDK4/6 Inhibitor-Based Treatments in Metastatic Breast Cancer
Authors: Shikanai Ayana , Horimoto Yoshiya , Ishizuka Yumiko , Uomori Toshitaka , Nakai Katsuya , Arakawa Atsushi , Saito Mitsue 
Published: January 2022

Background: Resistance to endocrine therapy has been a major obstacle in the management of hormone receptor (HR)-positive metastatic breast cancer (MBC). Meanwhile, a number of treatments are available to such patients, and physicians often encounter difficulties in choosing the most appropriate treatments for individual patients. The combination of CDK 4/6 inhibitors (CDKi) and endocrine therapy has now become a standard treatment for HR-positive and human epidermal growth factor receptor 2 (HER2)-negative MBC. However, no predictive markers for CDKi-based treatments have been established. Considering their side effects and the financial burden on patients, identifying such markers is crucial. Methods: Clinicopathological features of 107 patients with HR-positive HER2-negative MBC, who received CDKi-based treatments at our institution were retrospectively investigated. HR status in distant metastatic lesions and immunocompetent cells in peripheral blood were also studied. Results: Progression-free survival (PFS) was significantly shorter in patients whose primary tumour was high grade ( P = 0.016) or high neutrophil-to-lymphocyte ratio (NLR) at baseline ( P = 0.017). Meanwhile, there were no differences in other factors, such as expression levels of hormone receptors. Patients whose metastatic lesions were of low tumour grade or high Ki67 labelling index had longer PFS, and such trends were more obvious than primary lesions. Conclusion: Our data indicate that tumour grade in primary lesion and NLR are potential predictive factors for CDKi-based treatments. Moreover, pathological assessment of metastatic lesions might also be useful.
A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice
Authors: Saha Asim , Hyzy Sharon , Lamothe Tahirih , Hammond Katelyn , Clark Nicholas , Lanieri Leanne , Bhattarai Prashant , Palchaudhuri Rahul , Gillard Geoffrey O. , Proctor Jennifer , Riddle Megan J. , Panoskaltsis-Mortari Angela , MacMillan Margaret L. , Wagner John E. , Kiem Hans-Peter , Olson Lisa M. , Blazar Bruce R. 
Published: January 2022

AbstractAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment of patients with nonmalignant or malignant blood disorders. Its success has been limited by graft-versus-host disease (GVHD). Current systemic nontargeted conditioning regimens mediate tissue injury and potentially incite and amplify GVHD, limiting the use of this potentially curative treatment beyond malignant disorders. Minimizing systemic nontargeted conditioning while achieving alloengraftment without global immune suppression is highly desirable. Antibody-drug-conjugates (ADCs) targeting hematopoietic cells can specifically deplete host stem and immune cells and enable alloengraftment. We report an anti-mouse CD45-targeted-ADC (CD45-ADC) that facilitates stable murine multilineage donor cell engraftment. Conditioning with CD45-ADC (3 mg/kg) was effective as a single agent in both congenic and minor-mismatch transplant models resulting in full donor chimerism comparable to lethal total body irradiation (TBI). In an MHC-disparate allo-HSCT model, pretransplant CD45-ADC (3 mg/kg) combined with low-dose TBI (150 cGy) and a short course of costimulatory blockade with anti-CD40 ligand antibody enabled 89% of recipients to achieve stable alloengraftment (mean value: 72%). When CD45-ADC was combined with pretransplant TBI (50 cGy) and posttransplant rapamycin, cyclophosphamide (Cytoxan), or a JAK inhibitor, 90% to 100% of recipients achieved stable chimerism (mean: 77%, 59%, 78%, respectively). At a higher dose (5 mg/kg), CD45-ADC as a single agent was sufficient for rapid, high-level multilineage chimerism sustained through the 22 weeks observation period. Therefore, CD45-ADC has the potential utility to confer the benefit of fully myeloablative conditioning but with substantially reduced toxicity when given as a single agent or at lower doses in conjunction with reduced-intensity conditioning.
3D AGSE-VNet: an automatic brain tumor MRI data segmentation framework
Authors: Guan Xi , Yang Guang , Ye Jianming , Yang Weiji , Xu Xiaomei , Jiang Weiwei , Lai Xiaobo 
Published: January 2022

Abstract
Background
Glioma is the most common brain malignant tumor, with a high morbidity rate and a mortality rate of more than three percent, which seriously endangers human health. The main method of acquiring brain tumors in the clinic is MRI. Segmentation of brain tumor regions from multi-modal MRI scan images is helpful for treatment inspection, post-diagnosis monitoring, and effect evaluation of patients. However, the common operation in clinical brain tumor segmentation is still manual segmentation, lead to its time-consuming and large performance difference between different operators, a consistent and accurate automatic segmentation method is urgently needed. With the continuous development of deep learning, researchers have designed many automatic segmentation algorithms; however, there are still some problems: (1) The research of segmentation algorithm mostly stays on the 2D plane, this will reduce the accuracy of 3D image feature extraction to a certain extent. (2) MRI images have gray-scale offset fields that make it difficult to divide the contours accurately.

Methods
To meet the above challenges, we propose an automatic brain tumor MRI data segmentation framework which is called AGSE-VNet. In our study, the Squeeze and Excite (SE) module is added to each encoder, the Attention Guide Filter (AG) module is added to each decoder, using the channel relationship to automatically enhance the useful information in the channel to suppress the useless information, and use the attention mechanism to guide the edge information and remove the influence of irrelevant information such as noise.

Results
We used the BraTS2020 challenge online verification tool to evaluate our approach. The focus of verification is that the Dice scores of the whole tumor, tumor core and enhanced tumor are 0.68, 0.85 and 0.70, respectively.

Conclusion
Although MRI images have different intensities, AGSE-VNet is not affected by the size of the tumor, and can more accurately extract the features of the three regions, it has achieved impressive results and made outstanding contributions to the clinical diagnosis and treatment of brain tumor patients.
A mixed-ethnicity myoclonus-dystonia patient with a novel SGCE nonsense mutation: a case report
Authors: de Leon Meliza Angelica J. , Rosales Raymond L. , Klein Christine , Westenberger Ana 
Published: January 2022

Abstract
Background
Myoclonus-dystonia is a rare movement disorder with an autosomal dominant inheritance pattern characterized by a combination of myoclonic jerks and dystonia that may have psychiatric manifestations. Our aim is to present neurologic and psychiatric phenotypic characteristics in the first Filipino bi-ethnic myoclonus-dystonia patient and her father.

Case presentation
We investigated a Filipino myoclonus-dystonia patient with a positive family history. This 21-year-old woman of mixed Filipino-Greek ethnicity presented with involuntary jerking movements of her upper extremities, head, and trunk. Her symptoms affected her activities of daily living which led her to develop moderate depression, mild to moderate anxiety, and mild obsessive-compulsive disorder (OCD). Her 49-year-old Greek father suffered from adolescence-onset myoclonus-dystonia.

Conclusion
Genetic testing revealed a novel epsilon-sarcoglycan (SGCE) gene nonsense mutation c.821C > A; p.Ser274* that confirmed our clinical diagnosis. For co-morbid anxiety, depression, and OCD, this patient was given duloxetine, in addition to clonazepam for the myoclonus and dystonia.
Leukoencephalopathy with brain calcifications and cysts (Labrune syndrome) case report: diagnosis and management of a rare neurological disease
Authors: Paff Michelle , Samuel Nardin , Alsafwani Noor , Paul Darcia , Diamandis Phedias , Climans Seth A. , Kucharczyk Walter , Ding Mandy Yi Rong , Gao Andrew F. , Lozano Andres M. 
Published: January 2022

Abstract
Background
Leukoencephalopathy with brain calcifications and cysts (LCC; also known as Labrune syndrome) is a rare genetic microangiopathy caused by biallelic mutations in SNORD118. The mechanisms by which loss-of-function mutations in SNORD118 lead to the phenotype of leukoencephalopathy, calcifications and intracranial cysts is unknown.

Case presentation
We present the histopathology of a 36-year-old woman with ataxia and neuroimaging findings of diffuse white matter abnormalities, cerebral calcifications, and parenchymal cysts, in whom the diagnosis of LCC was confirmed with genetic testing. Biopsy of frontal white matter revealed microangiopathy with small vessel occlusion and sclerosis associated with axonal loss within the white matter.

Conclusions
These findings support that the white matter changes seen in LCC arise as a consequence of ischemia rather than demyelination.
Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases
Authors: Makselis Almantas , Petroska Donatas , Kadziauskiene Aiste , Jaruseviciene Ruta , Ruzgys Andrius , Cimbalas Andrius , Besusparis Justinas , Asoklis Rimvydas S. 
Published: January 2022

Abstract
Background
Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by local nonspecific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction is caused by malignancies.
Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare their clinical manifestations.

Methods
This retrospective clinical study included 275 patients with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or nonspecific pathology groups and subdivided according to the level of inflammation. Histological and clinical data were analyzed.

Results
Three tumors (1.1%) (an adenoid cystic carcinoma, an eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic nongranulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). The other 81 (29.5%) were subacute, acute forms of nongranulomatous inflammation, tumors and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, and two (0.7%) patients had a palpable mass near the medial canthal tendon, which was identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, duration or case history between the nonspecific pathology and tumor groups (p = 0.292).

Conclusions
Chronic nongranulomatous inflammation of the lacrimal sac was the most common finding among acquired nasolacrimal duct obstruction cases. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.
Use of latent profile analysis and k-means clustering to identify student anxiety profiles
Authors: Liu Fang , Yang Dan , Liu Yueguang , Zhang Qin , Chen Shiyu , Li Wanxia , Ren Jidong , Tian Xiaobin , Wang Xin 
Published: January 2022

Abstract
Background
Anxiety disorders are often the first presentation of psychopathology in youth and are considered the most common psychiatric disorders in children and adolescents. This study aimed to identify distinct student anxiety profiles to develop targeted interventions.

Methods
A cross-sectional study was conducted with 9738 students in Yingshan County. Background characteristics were collected and Mental Health Test (MHT) were completed. Latent profile analysis (LPA) was applied to define student anxiety profiles, and then the analysis was repeated using k-means clustering.

Results
LPA yielded 3 profiles: the low-risk, mild-risk and high-risk groups, which comprised 29.5, 38.1 and 32.4% of the sample, respectively. Repeating the analysis using k-means clustering resulted in similar groupings. Most students in a particular k-means cluster were primarily in a single LPA-derived student profile. The multinomial ordinal logistic regression results showed that the high-risk group was more likely to be female, junior, and introverted, to live in a town, to have lower or average academic performance, to have heavy or average academic pressure, and to be in schools that have never or occasionally have organized mental health education activities.

Conclusions
The findings suggest that students with anxiety symptoms may be categorized into distinct profiles that are amenable to varying strategies for coordinated interventions.
Medicines and vaccines supply chains challenges in Nigeria: a scoping review
Authors: Olutuase Victory O. , Iwu-Jaja Chinwe J. , Akuoko Cynthia P. , Adewuyi Emmanuel O. , Khanal Vishnu 
Published: January 2022

AbstractBackgroundMedicines and vaccines supply chains represent critical systems for realising one of the major targets of the United Nations’ third Sustainable Development Goals (SDGs)—access to safe, effective, quality, and affordable essential medicines and vaccines, for all. However, evidence suggests the system is confronted with several challenges in many low-medium income countries, including Nigeria. This scoping review aims to summarize the available evidence on the challenges of medicines and vaccines supply chain system in Nigeria.ResultsWe searched relevant databases including Scopus and Web of Science for studies published between January 2005 and August 2020 on the challenges associated with medicines and vaccines supply chain systems in Nigeria. Our findings implicate several factors including difficulty with medicines or vaccines selection, procurement, distribution, and inventory management. Others included poor storage infrastructure, financial constraints, insecurity, transportation challenges, inadequate human resources, weak, or poorly implemented policies. These challenges mostly resulted in stock-outs of essential medicines which notably got worsened during the current COVID-19 pandemic.ConclusionOur study is a wake-up call on the need to prioritise the critical sector of the supply chain systems for medicines and vaccines in Nigeria. Effective implementation of existing policies, improved security, strengthening of the health system through adequate budgetary allocations, and provision of infrastructure including regular availability of electricity are keys to surmounting the challenges and improving access to medicines or vaccines in Nigeria.
Economic impact of switching from partially combined vaccine “Pentaxim® and hepatitis B” to fully combined vaccine “Hexaxim®” in the Malaysian National Immunization Program
Authors: Aljunid Syed Mohamed , Al Bashir Lama , Ismail Aniza Binti , Aizuddin Azimatun Noor , Rashid S. A. Zafirah Abdul , Nur Amrizal Muhammad 
Published: January 2022

Abstract
Background
The decision to implement new vaccines should be supported by public health and economic evaluations. Therefore, this study was primarily designed to evaluate the economic impact of switching from partially combined vaccine (Pentaxim® plus hepatitis B) to fully combined vaccine (Hexaxim®) in the Malaysian National Immunization Program (NIP) and to investigate healthcare professionals (HCPs)’ and parents’/caregivers’ perceptions.

Methods
In this economic evaluation study, 22 primary healthcare centers were randomly selected in Malaysia between December 2019 and July 2020. The baseline immunization schedule includes switching from Pentaxim® (four doses) and hepatitis B (three doses) to Hexaxim® (four doses), whereas the alternative scheme includes switching from Pentaxim® (four doses) and hepatitis B (three doses) to Hexaxim® (four doses) and hepatitis B (one dose) administered at birth. Direct medical costs were extracted using a costing questionnaire and an observational time and motion chart. Direct non-medical (cost for transportation) and indirect costs (loss of productivity) were derived from parents’/caregivers’ questionnaire. Also, HCPs’ and parent’s/caregivers’ perceptions were investigated using structured questionnaires.

Results
The cost per dose of Pentaxim® plus hepatitis B vs. Hexaxim® for the baseline scheme was Malaysian ringgit (RM) 31.90 (7.7 United States dollar [USD]) vs. 17.10 (4.1 USD) for direct medical cost, RM 54.40 (13.1 USD) vs. RM 27.20 (6.6 USD) for direct non-medical cost, RM 221.33 (53.3 USD) vs. RM 110.66 (26.7 USD) for indirect cost, and RM 307.63 (74.2 USD) vs. RM 155.00 (37.4 USD) for societal (total) cost. A similar trend was observed for the alternative scheme. Compared with Pentaxim® plus hepatitis B, total cost savings per dose of Hexaxim® were RM 137.20 (33.1 USD) and RM 104.70 (25.2 USD) in the baseline and alternative scheme, respectively. Eighty-four percent of physicians and 95% of nurses supported the use of Hexaxim® in the NIP. The majority of parents/caregivers had a positive perception regarding Hexaxim® vaccine in various aspects.

Conclusions
Incorporation of Hexaxim® within Malaysian NIP is highly recommended because the use of Hexaxim® has demonstrated substantial direct and indirect cost savings for healthcare providers and parents/caregivers with a high percentage of positive perceptions, compared with Pentaxim® plus hepatitis B.

Trial registration
Not applicable.