bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the Frequency‐Dependent Effective Excess Charge Density in Partially Saturated Porous Media
Authors: Solazzi Santiago G. , Thanh Luong Duy , Hu Kayian , Jougnot Damien 
Published: October 2022

AbstractIn the context of seismoelectric and self‐potential surveying, the effective excess charge density and the electrokinetic coupling coefficient are key parameters relating the measured electrical potential and the hydraulic characteristics of the explored porous media. In this work, we present a novel flux averaging approach that permits to estimate the frequency‐dependent effective excess charge density in partially saturated porous media. For this, we conceptualize the porous medium as a partially saturated bundle of capillary tubes under oscillatory flux conditions. We account for the pore size distribution (PSD) to determine the capillary‐pressure saturation relationship of the corresponding medium, which, in turn, permits to determine the pore scale saturation. We then solve the Navier‐Stokes equations within the saturated capillaries and, by means of a flux‐averaging procedure, obtain upscaled expressions for: (a) the effective excess charge density, (b) the effective permeability, and (c) the electrokinetic coupling coefficient, which are functions of the saturation and the probing frequency. We analyze and explain the characteristics of these functions for three different PSDs: fractal, lognormal, and double lognormal. It is shown that the PSD characteristics have a strong effect on the corresponding electrokinetic response. The proposed flux‐averaging approach has an excellent capability for reproducing experimental measurements and models in the literature, which are otherwise based on well‐known empirical relationships. The results of this work constitute a useful framework for the interpretation of electrokinetic signals in partially saturated media.
Occurrence Rates of SuperDARN Ground Scatter Echoes and Electron Density in the Ionosphere
Authors: Koustov Alexander V. , Ullrich Sydney , Ponomarenko Pavlo V. , Ghalamkarian Nejad Mehdi , Themens David R. , Gillies Robert G. 
Published: October 2022

AbstractGround scatter (GS) echoes in Super Dual Auroral Radar Network (SuperDARN) observations have been always expected to occur under high‐enough electron density in the ionosphere providing sufficient bending of high frequency radio wave paths toward the ground. In this study, we provide direct evidence statistically supporting this notion by comparing the GS occurrence rate for the Rankin Inlet SuperDARN radar and the F region peak electron density measured at Resolute Bay by the Canadian Advanced Digital Ionosonde and incoherent scatter radars RISR‐N/C. We show that the occurrence rate increases with roughly linearly up to about and the trend saturates at larger . One expected consequence of this relationship is correlation in seasonal and solar cycle variations of the GS echo occurrence rate and . GS occurrence rates for a number of SuperDARN radars at middle latitudes, in the auroral zone and in the polar cap are considered separately for daytime and nighttime. The data indicate that the daytime occurrence rates are maximized in winter and nighttime occurrence rates are maximized in summer for middle latitude and auroral zone radars in the Northern Hemisphere, consistent with the winter anomaly (WA) phenomenon. The effect is most evident in the North American and Japanese sectors, and the quality of WA signatures deteriorates in the European and, especially, in the Australian sectors. The effect does not exist in the South American sector and in the polar caps of both hemispheres.
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia
Authors: Hu Cheng-Long , Chen Bing-Yi , Li Zijuan , Yang Tianbiao , Xu Chun-Hui , Yang Ruirui , Yu Peng-Cheng , Zhao Jingyao , Liu Ting , Liu Na , Shan Bin , Zhang Qunling , Song Junhong , Fei Ming-Yue , Zong Li-Juan , Zhang Jia-Ying , Wu Ji-Chuan , Chen Shu-Bei , Wang Yong , Chang Binhe , Hou Dan , Liu Ping , Jiang Yilun , Li Xiya , Chen Xinchi , Deng Chu-Han , Ren Yi-Yi , Wang Roujia , Jin Jiacheng , Xue Kai , Zhang Ying , Du Meirong , Shi Jun , Wu Ling-Yun , Chang Chun-Kang , Shen Shuhong , Chen Zhu , Chen Sai-Juan , Liu Xiaolong , Sun Xiao-Jian , Zheng Mingyue , Wang Lan 
Published: October 2022

AbstractAberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly expressed in AML and predicts poor prognosis. UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs. Mechanistically, UHRF1 directly interacts with Sin3A-associated protein 30 (SAP30) through two critical amino acids, G572 and F573 in its SRA domain, to repress gene expression. Depletion of UHRF1 or SAP30 derepresses an important target gene, MXD4, which encodes a MYC antagonist, and leads to suppression of leukemogenesis. Further knockdown of MXD4 can rescue the leukemogenesis by activating the MYC pathway. Lastly, we identified a UHRF1 inhibitor, UF146, and demonstrated its significant therapeutic efficacy in the myeloid leukemia PDX model. Taken together, our study reveals the mechanisms for altered epigenetic programs in AML and provides a promising targeted therapeutic strategy against AML.
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation
Authors: Ortiz-Zapater Elena , Bagley Dustin C. , Hernandez Virginia Llopis , Roberts Luke B. , Maguire Thomas J. A. , Voss Felizia , Mertins Philipp , Kirchner Marieluise , Peset-Martin Isabel , Woszczek Grzegorz , Rosenblatt Jody , Gotthardt Michael , Santis George , Parsons Maddy 
Published: October 2022

AbstractAirway inflammation and remodelling are important pathophysiologic features in asthma and other respiratory conditions. An intact epithelial cell layer is crucial to maintain lung homoeostasis, and this depends on intercellular adhesion, whilst damaged respiratory epithelium is the primary instigator of airway inflammation. The Coxsackievirus Adenovirus Receptor (CAR) is highly expressed in the epithelium where it modulates cell-cell adhesion stability and facilitates immune cell transepithelial migration. However, the contribution of CAR to lung inflammation remains unclear. Here we investigate the mechanistic contribution of CAR in mediating responses to the common aeroallergen, House Dust Mite (HDM). We demonstrate that administration of HDM in mice lacking CAR in the respiratory epithelium leads to loss of peri-bronchial inflammatory cell infiltration, fewer goblet-cells and decreased pro-inflammatory cytokine release. In vitro analysis in human lung epithelial cells confirms that loss of CAR leads to reduced HDM-dependent inflammatory cytokine release and neutrophil migration. Epithelial CAR depletion also promoted smooth muscle cell proliferation mediated by GSK3β and TGF-β, basal matrix production and airway hyperresponsiveness. Our data demonstrate that CAR coordinates lung inflammation through a dual function in leucocyte recruitment and tissue remodelling and may represent an important target for future therapeutic development in inflammatory lung diseases.
Field-induced ultrafast modulation of Rashba coupling at room temperature in ferroelectric α-GeTe(111)
Authors: Kremer Geoffroy , Maklar Julian , Nicolaï Laurent , Nicholson Christopher W. , Yue Changming , Silva Caio , Werner Philipp , Dil J. Hugo , Krempaský Juraj , Springholz Gunther , Ernstorfer Ralph , Minár Jan , Rettig Laurenz , Monney Claude 
Published: October 2022

AbstractRashba materials have appeared as an ideal playground for spin-to-charge conversion in prototype spintronics devices. Among them, α-GeTe(111) is a non-centrosymmetric ferroelectric semiconductor for which a strong spin-orbit interaction gives rise to giant Rashba coupling. Its room temperature ferroelectricity was recently demonstrated as a route towards a new type of highly energy-efficient non-volatile memory device based on switchable polarization. Currently based on the application of an electric field, the writing and reading processes could be outperformed by the use of femtosecond light pulses requiring exploration of the possible control of ferroelectricity on this timescale. Here, we probe the room temperature transient dynamics of the electronic band structure of α-GeTe(111) using time and angle-resolved photoemission spectroscopy. Our experiments reveal an ultrafast modulation of the Rashba coupling mediated on the fs timescale by a surface photovoltage, namely an increase corresponding to a 13% enhancement of the lattice distortion. This opens the route for the control of the ferroelectric polarization in α-GeTe(111) and ferroelectric semiconducting materials in quantum heterostructures.
Human cooperation in changing groups in a large-scale public goods game
Authors: Otten Kasper , Frey Ulrich J. , Buskens Vincent , Przepiorka Wojtek , Ellemers Naomi 
Published: October 2022

AbstractHow people cooperate to provide public goods is an important scientific question and relates to many societal problems. Previous research studied how people cooperate in stable groups in repeated or one-time-only encounters. However, most real-world public good problems occur in groups with a gradually changing composition due to old members leaving and new members arriving. How group changes are related to cooperation in public good provision is not well understood. To address this issue, we analyze a dataset from an online public goods game comprising approximately 1.5 million contribution decisions made by about 135 thousand players in about 11.3 thousand groups with about 234 thousand changes in group composition. We find that changes in group composition negatively relate to cooperation. Our results suggest that this is related to individuals contributing less in the role of newcomers than in the role of incumbents. During the process of moving from newcomer status to incumbent status, individuals cooperate more and more in line with incumbents.
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
Authors: Yan Ying , Niu Zhoumin , Sun Chao , Li Peng , Shen Siyi , Liu Shengnan , Wu Yuting , Yun Chuyu , Jiao Tingying , Jia Sheng , Li Yuying , Fang Zhong-Ze , Zhao Lin , Wang Jiqiu , Xie Cen , Jiang Changtao , Li Yan , Feng Xiaoyun , Hu Cheng , Jiang Jingjing , Ying Hao 
Published: October 2022

AbstractThyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatment with a GLP-1 receptor antagonist attenuates the effects of T3 on insulin and glucose levels. By using mice lacking hepatic TH receptor β (TRβ) and a liver-specific TRβ-selective agonist, we demonstrate that TRβ-mediated hepatic TH signalling is required for both the regulation of GLP-1 production and the insulinotropic and glucose-lowering effects of T3. Moreover, administration of a liver-targeted TRβ-selective agonist increases GLP-1 and insulin levels and alleviates hyperglycemia in diet-induced obesity. Mechanistically, T3 suppresses Cyp8b1 expression, resulting in increased the levels of Farnesoid X receptor (FXR)-antagonistic bile acids, thereby potentiating GLP-1 production and insulin secretion by repressing intestinal FXR signalling. T3 correlates with both plasma GLP-1 and fecal FXR-antagonistic bile acid levels in people with normal thyroid function. Thus, our study reveals a role for hepatic TH signalling in glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism.
Revisiting the COVID-19 fatality rate and altitude association through a comprehensive analysis
Authors: Bridgman Carson , Gerken Jacob , Vincent Joshua , Brooks Amanda E. , Zapata Isain 
Published: October 2022

AbstractThe emergence of COVID-19 virus has led to a pandemic with staggering morbidity and mortality. There is evidence showing that pre-existing conditions and environmental factors are associated with worse COVID-19 outcomes. Among these conditions, altitude is of particular interest. Altitude has been shown to influence the morbidity and mortality of multiple chronic pathologies such as cardiovascular disease, chronic obstructive pulmonary disease and lung cancer. COVID-19 fatality rate has been associated with as altitude as well, but findings are disputed. Therefore, we revisit this assessment with a comprehensive analysis of the relationship between COVID-19 fatality rates and altitude for the Mountain region of the United States while considering the effect of additional comorbidities and sociodemographic factors. A Generalized Additive Model (GAM) approach using one year of county data adjusted by population density was performed to evaluate associations within states and for the whole region. Our analysis revealed a consistent effect where COVID-19 case-fatality rate is decreased with higher altitude, even when controlling for pre-existing conditions and certain demographic variables. In summary, the work presented provides evidence that suggests that the protective effects of high altitude are likely to be influenced by physiologic factors but demographic trends that are associated with life at high altitude must also be considered.
ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma
Authors: Wang Bin , Fu Jiantao , Lin Yuanji , Lou Yi , Lu Anqian , Yang Jin 
Published: October 2022

AbstractAutophagy plays a critical role in tumor pathogenesis. However, autophagy-related signature in Hepatocellular carcinoma (HCC) has not been revealed yet. We quantified the levels of various cancer hallmarks and identified ATG101 as the major risk factor for overall survival in HCC. A robust ATG101-related gene signature (ATS) for prognosis was constructed using a combination of bioinformatic and statistical approaches. Additionally, genetic and immunological properties were measured between ATS-high and ATS-low groups. The ATS signature was associated with shortened overall survival in HCC patients independently of clinicopathological characteristics. ATS status defines an inflamed yet exhausted tumor microenvironment, in which the activities of the exhausted CD8+ or CD4+ T cells were strongly associated with ATS. The ATS signature predicts the drug resistance to the immunotherapy, thus a combination of targeted therapy and immunotherapy might be suitable for ATS-high patients. This work shed light on the function of ATG101-related genes in HCC and revealed that the ATS signature may be a useful prognostic biomarker for differentiating molecular and immunological features and predicting probable response to the therapy.
Clinical association between trace elements of tear and dry eye metrics
Authors: Chen Ying-Jen , Chen Yuan-Yuei , Lai Ching-Huang 
Published: October 2022

AbstractTrace elements exposure is proposed to play a role in the pathogenesis of the systemic disease. Emerging studies have suggested that trace metal exposure may contribute to dry eye disease. Our study primarily aimed to investigate the association between trace metal exposure in tear samples and the presence of dry eye metrics in the shipyard industry. Overall, 84 eligible participants from the shipyard industry were included in this cross-sectional study. The parameters for identifying dry eye symptoms included O.S.D.I., SPEED, N.I.B.U.T., and ocular surface conditions, such as tear meniscus height, eye blinking, and meibomian gland area were performed by S.B.M. sistemi ocular surface analyzer. The concentration of tear trace elements was detected by inductively coupled plasma mass spectroscopy (ICP-MS). The association between tear trace elements and dry eye parameters was investigated using regression models. Participants in the exposure group had significantly higher levels of tear Pb than the control group. In the exposure group, tear Pb was significantly associated with increased SPEED and O.S.D.I. score with beta coefficients of 0.144 (95% CI 0.092, 0.197), 0.121 (95% CI 0.049, 0.194), respectively, and decreased lower and upper meibomian gland area with beta coefficients of − 0.158 (− 0.283, − 0.033) and − 0.228 (− 0.396, − 0.061), respectively. Tear trace elements exposure is considered to impact the appearance of dry eye metrics. Improving the occupational environment and monitoring the ocular surface health may benefit workers under exposure to trace elements.
Morphometric description of the koala humerus using microcomputed tomography
Authors: Hawkins Jason , Basa Rachel M. , Norton Matthew J. , Johnson Kenneth A. 
Published: October 2022

AbstractThe current prognosis for successful return to function in koalas with appendicular fractures is poor despite being the most common fracture type to result in successful rehabilitation. The forelimb, particularly the humerus, plays a critical role in stabilisation and support while climbing trees. Successful rehabilitation therefore requires adequate internal stabilisation to promote bone healing and faster return to function. Current knowledge of koala limb bone morphometry is lacking and would provide useful clinical insight for future orthopaedic research, particularly with regards to recommendations regarding implant size and type. In this study microcomputed tomography (micro-CT) was used to describe bone length, internal and external diameters, and cortical thickness at five transverse levels along the humerus of skeletally mature koala cadavers. Qualitative descriptions were also made regarding bone features deemed clinically relevant to potential fracture repair techniques. Mean humeral length was 114.3 mm (95% CI 107.29–121.31 mm). Mediolateral diameters were greater than craniocaudal diameters at each measurement level, and the diaphysis has a distally tapering medullary cavity. Diaphyseal cortices were relatively homogenous with slight distal thickening, and medial cortices were thickest along the entire bone. The bone protuberances of the deltoid and supinator ridges projected most of the way down the lateral surface of the bone while the medial surface remained relatively uniform. Distal to the deltoid ridge the humerus curved caudally, terminating at a craniocaudally flattened distal epiphysis. Morphometric descriptions provided in this study will serve as a useful reference for future research, guiding orthopaedic surgery and improving prognosis of koala humeral fractures.
Investigation of bactericidal effect of a mid-infrared free electron laser on Escherichia coli
Authors: Toyama Toshizo , Fujioka Jun , Watanabe Kiyoko , Yoshida Ayaka , Sakuma Takaaki , Inaba Keitaro , Imai Takayuki , Nakajima Takashi , Tsukiyama Koichi , Hamada Nobushiro , Yoshino Fumihiko 
Published: October 2022

AbstractThe rapid increase in the number of bacteria that are resistant to many commonly used antimicrobial agents and their global spread have become a major problem worldwide. In particular, for periodontal disease, which is a localized infection, there is a growing need for treatment methods that do not primarily involve antimicrobial agents, and antimicrobial photodynamic therapy (aPDT) is attracting attention. In this study, the bactericidal effects of a mid-infrared free electron laser (MIR-FEL) on E. coli were investigated as a basic study to examine the applicability of MIR-FELs, which can selectively excite molecular vibrations due to their wavelength tunability, to aPDT. The optimal irradiation wavelengths to be examined in this study were determined from the infrared spectrum of the bacteria, which was obtained using Fourier transform infrared spectroscopy. Five irradiation wavelengths (6.62, 6.88, 7.14, 8.09 and 9.26 µm) were selected from the FT-IR spectrum, and we found that the bactericidal effects at a wavelength of 6.62 µm were markedly stronger than those observed at the other wavelengths. At this wavelength corresponding to the Amide II band, the bacterial survival rate decreased significantly as the irradiation time increased. On the contrary, irradiation of a neodymium-doped yttrium aluminum garnet (Nd: YAG) laser at 1.06 µm exhibited no distinct bactericidal effect. No morphological changes were observed after MIR-FEL irradiation, suggesting that a bacterial organelle molecule may be the target of MIR-FEL irradiation, but the exact target was not identified. Furthermore, the temperature change induced in the culture medium by the laser irradiation was ± 1.5 °C at room temperature. These results suggest that the bactericidal effects of MIR-FEL are derived from photochemical reactions involving infrared photons, since E. coli is usually killed by heating it to 75 °C for 1 min or longer.
LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells
Authors: Xu Ying , Cao Luxi , Ji Shuiyu , Shen Wei 
Published: October 2022

AbstractThis study aimed to explore the regulatory role of lncRNA ANRIL/miR-181b-5p/S1PR1 in UC. UC mouse model was established by 5/6th nephrectomy. We detected body weight, serum levels of renal function and inflammatory factors (biochemical analyzer/ELISA), and cardiac parameters (echocardiography). HE and Masson staining showed the pathological changes and fibrosis in myocardial and nephridial tissues. The expression of ANRIL, miR-181b-5p, and S1PR1 were detected by qRT-PCR or Western blot/immunofluorescence. T cells activation was analyzed by Flow cytometry. ANRIL/S1PR1 were up-regulated and miR-181b-5p was down-regulated in UC mice. ANRIL silencing up-regulated miR-181b-5p and down-regulated S1PR1 (a target of miR-181b-5p). ANRIL silencing increased the body weight, recovered renal function [decreased blood urea nitrogen (BUN) and serum creatinine (Scr)] and cardiac function [decreased left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV systolic anterior wall thickness (LVAWS), LV end-diastolic anterior wall thickness (LVAWD), myocardial performance index (MPI), and isovolumic relaxation time (IVRT); increased LV ejection fraction (LVEF), LVEF/MPI, fractional shortening (FS), and E- and A-waves (E/A)], inhibited the inflammation [decreased interferon (IFN)-γ, interleukin (IL)-2, IL-10, and tumor necrosis factor (TNF)-α], and relieved pathological injuries and fibrosis. ANRIL silencing also recovered the viability and inhibited the inflammation of activated T cells in vitro, and inhibited T cell activation in UC mice in vivo. In addition, miR-181b-5p overexpression exhibited same effects with ANRIL silencing in UC. ANRIL silencing inhibited T cell activation through regulating miR-181b-5p/S1PR1, contributing to the remission of UC.