bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Combine Spectrophotometric and Chromatographic Method Development and Validation of Levetiracetam Bulk And Tablet Dosage Form
Authors: Pimpale Amol , Pagare Rutuja , Aher Smita , Phadtare Dipti 
Published: March 2022

Objective: Objective of the present analytical research work was to develop and validate Spectrophotometric method and High Performance Liquid Chromatographic method (HPLC Method) for the Levetiracetam bulk and tablet dosage form
Methods: A spectrophotometric method and a HPLC method have been developed and validated for estimation of Levetiracetam in bulk.
Method A (UV SPECTROMETRY Method): Methanol was used for the preparation of stock and working standard solutions of the drugs. 400-200nm UV range was used to scanned standard solutions of drugs using UV spectrophotometer. The λmax of Levetiracetam was found to be 220 nm.
Method B (HPLC Method): The HPLC method for Levetiracetam was developed using cosmosil C18 (4.6 mm x 250 mm, particle size: 5 μm), as stationary particle, isocratic mode. Methanol: ACN: Water (60:20:20) pH3 as a mobile phase. The mobile phase was maintained at a flow rate of 1 ml / min and the detection was carried out at 220 nm. Both the methods were validated according to the ICH guidelines.
Results: Levetiracetam was found to be linear in the concentration range of 10-50 µg/ml for spectrophotometric and HPLC method. Retention time was found to be 4.5 min for Levetiracetam.
Interpretation and Conclusion: Results of validation study were found to be satisfactory. So, the methods can be successfully applied for the routine analysis of Levetiracetam.
Diabetes Mellitus and the Possibility of Developing Dementia
Authors: Kumar S. Nelson , Basha V. Wazeed , Sireesha C. , Gnanaprakasam G. Jacob , Kalyan M. Pavan , Padmakar Somanaboina 
Published: March 2022

Background: Dementia and cognitive dysfunction have many causes. There is strong evidence that diabetes mellitus (DM) increases the risk of cognitive impairment and dementia. A prophylactic approach, optimal glycaemic control, and identification of diabetic risk factors are essential to preventing cognitive complications.
Objective: The main objectives of this study are to assess the severity of dementia by using the Clinical Dementia Rating scale (CDR), and the effect of longevity of diabetes mellitus on the severity of dementia.
Method: It is a Hospital-based prospective observational study, in which the patients were enrolled into the study after taking an informed consent form from them based on the inclusion and exclusion criteria.
Results: Out of 80 patients, 62(77.5%) were suffering with dementia and 18(22.5%) were found to be normal. The diabetes patients included in this study had a duration of diabetes ranges from 6 to 30 years. Using the CDR scale, 24 of them (30%) were diagnosed with moderate dementia.
Conclusion: According to our findings, we emphasize the need to consider DM as a potential risk factor for dementia.
Evaluation of Antidiabetic Potential of Eucalyptus Globulus Plant Extract In Alloxan-Induced Diabetic Rats
Authors: Kamble Ujwala B. , Chaware V. J , Redasani V. K. 
Published: March 2022

Objective: Evaluation of Antidiabetic Potential of Eucalyptus globules Plant Extract in Alloxan- Induced Diabetic Rats.
Method: Methanolic leaves extract of Eucalyptus globulus plant was prepared by Soxhlet extraction method and stored in refrigerator at 4℃ for two days before use. Male Albino Wistar rats were made diabetic at the dose of Alloxan (150mg/kg/day i.p.). Methanolic leaves extract of Eucalyptus globulus plant (200mg/kg, 400mg/kg & 600mg/kg/day p.o.) was screened for antidiabetic activity. Standard drug Glibenclamide (0.5mg/kg/day i.p.) was administered to the second group of animals for 14 days. Blood glucose level and body weight of rats were recorded on Initial & Final days of treatment. Further hypoglycemic & OGTT evaluation were done. At the end of treatment biochemical estimations & histopathological examination of pancreas were also carried out.
Result: The statistical data indicated, 14 Days oral administration of Methanolic leaves extract of Eucalyptus globulus plant caused a significant (????< 0.05) reductions in blood glucose level, hypoglycemicpotential, significant oral glucose tolerance &gain in body weight as compared with toxic control group. Further showed improvement in altered biochemical parameters associated with diabetes. Concurrent histopathological examination of pancreas of these animals showed regeneration by Methanolic leaves extract which were earlier necrosed by Alloxan.
Conclusion: Results obtained in this study substantiate the Antidiabetic potential of Methanolic leaves extract of Eucalyptus globulus plant the source of Ellagitannins a bioactive polyphenol and could be considered for further evaluation in clinical studies and drug development.
Novel Corona Virus: Its Origin, Current Dignosis And Various Diseases Arises Due To Covid-19
Authors: B Gawali Mangesh , R Sangle Rahul 
Published: March 2022

Severe Acute Respiratory Syndrome Coronavirus-2 is responsible for the emergence and propagation of new coronavirus illness 2019 i.e. COVID-19, have posed a significant threat to global public health. Coronaviruses are enveloped single positive-stranded RNA viruses with the biggest viral genome (26-33kb) among the RNA viruses, belonging to the Corona viridae family.This potentially deadly virus spreads quickly from person to person. To control the epidemics of COVID-19, large-scale measures such as isolation of infected patients, social distancing, frequent washing of hands, and the usage of face masks have been implemented.In this review, we provide a brief overview of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus outbreaks,its origin, symptoms, clinical features, preventive measures, current diagnostic tools and therapeutic strategies. We also discuss about various diseases arises due to COVID-19 pandemic.
Repurposed Drugs and Alternate Therapeutic Possibilities for Challenges Posed By Covid-19
Authors: Verma Khushbu , Kapoor Neha , Kumar Lamha , Yadav Neelam , Mondal Ghorai Soma 
Published: March 2022

Pandemics like SARS-CoV-2 and its associated illness named COVID-19 (coronavirus disease 2019) have become a regular occurrence in the past recent decades. Though, novel Coronavirus devastated human lives, its earlier cousins SARS-CoV1, MERS and lesser known infections like 229E, NL63, OC43, HK01 were less threatening. Humankind should brace up towards identifying, managing and finding a suitable cure to prevent incidence of such deadly diseases.it is a well-known fact that viral diseases can be curbed only with vaccines. In this respect, the world has witnessed both the design and delivery of vaccines against SARS-CoV2 in a record time. Candidates for Vaccines designed vary from targeting proteins or nucleic acids (DNA and RNA) of the virus, with or without adjuvants with a potency to generate memory. Though, this has been lauded by the entire humankind, there is still the need for other therapeutics to control and treat COVID-19. Therapeutic Drugs are inexhaustible group of molecules that showed some promise in diagnosis, treatment or prevention of SARS-CoV-2 but provide no form of ‘memory’. In this Review, we summarize the current knowledge on the therapeutic options other than vaccines or licensed antiviral drugs that can be repurposed to be considered for the treatment and prevention of the SARS-CoV-2 virus.
Assessment of antiurolithiatic potential of gallic acid on calcium oxalate crystallization and ethylene glycol induced lithiasis
Authors: Patel Neeraj Kumar , Basedia Deepak Kumar , Dubey B. K. 
Published: March 2022

In the present work, the effect of gallic acid on nucleation and aggregation of calcium oxalate crystals and on ethylene glycol induced lithiasis was evaluated. Gallic acid is a natural phenolic compound found in several fruits and medicinal plants. It is reported to have several health-promoting effects. The presence of peaks at 3700, 1715, 1550-1650 are indicative of the presence of hydroxyl, carbonyl, and aromatic ring respectively. The results of solubility analysis indicate that gallic acid is soluble in organic solvents easily and is partially or sparingly soluble in aqueous solution. Gallic acid was able to inhibit the rate of nucleation as well as aggregation of calcium oxalate crystals in the in vitro experiment. It is exerted diuretic action in rats and was able to decrease the activity of the biomarkers of lithiasis viz. lactate dehydrogenase and alkaline phosphatase in ethylene glycol induced lithiatic rats. It could be concluded from the study that gallic acid is a potent anti urolithiatic compound and can be optimized for treatment of kidney stones.
Application of Red Dragon Fruit Dyes as Staining in Histological Study
Authors: Asra Ridho , R Rusdi , Fitrina Indah Kemala , Nessa Nessa 
Published: March 2022

Background: The betacyanin pigment found in dragon fruit flesh (Hylocereus costaricensis (F.A.C.Weber) Britton & Rose) has many advantages, for instance as a tissue histology dye.
Objectives: determining the properties of organs stained with betacyanin red dye and finding alternative histology colors to replace synthetic hematoxylin-eosin dyes.
Summary of contents of the article: The flesh of the red dragon fruit (Hylocereus costaricensis (F.A.C.Weber) Britton & Rose) was extracted using the Ultrasonic Assisted Extraction (UAE) method. The study employed six male white mice divided into two treatment groups: a placebo group induced with 1% Na.CMC carrier solution and a positive control group generated a toxic dose of paracetamol. The results were visually compared to hematoxylin-eosin with standard betacyanin and betacyanin extract of red dragon fruit flesh concentrations of 50% (v/v), 80% (v/v), and 100% (v/v).
Conclusion: Betacyanin from the flesh of the red dragon fruit can be applied as a histological dye in the liver of male white mice and as a counterstaining hematoxylin as a substitute for eosin dye at a concentration of 100% (v/v).
Development and Validation of Difference Spectrophotometric Method for Simultaneous Estimation of Rosuvastatin Calcium and Aspirin in Marketed Formulation
Authors: Padmavathi R , Padmavathi Y , Babu N Raghavendra , Akhila V , Keerthi G 
Published: March 2022

Objective: To develop and validate a simple Vierordt method for the simultaneous estimation of rosuvastatin calcium (RSV ca) and aspirin (ASP) in fixed dose combination capsules by difference spectrophotometry technique in the UV region. Difference spectrophotometry is based on the utilization of difference absorption spectra corresponding to the same compound obtained at two different pH values.
Methodology: The difference in spectral characteristics for the two drugs was observed in 0.01N acetic acid and 0.01N NaOH. The simultaneous equations were developed using difference absorbance and absorptivity values of the two drugs measured and calculated at 243.2nm and 297nm for RSV ca and ASP respectively.
Results: Two drugs have shown very good linearity in the concentration range of 10-100µg/ml. The methods were validated as per ICH guidelines for the limit of detection, the limit of quantification, accuracy, and precision, which were found to be within the acceptable limits. The validated method was successfully applied for the analysis of rosuvastatin calcium and aspirin in fixed dose combination capsules.
Conclusion: Because this approach is simple and does not require a particular programme, it can be used as a substitute for LC methods in quality control laboratories that lack the necessary equipment for those techniques.
The relationship between Hedonic value and utilitarian value with behavioral intentions and customers satisfaction in Gorgan fast foods
Authors: Zabihi Rad Arash , Didehkhani Hosein 
Published: March 2022

This study examines the relationship between delightful and useful values with behavioral ideas and customers satisfaction in Grogan fast foods. Methodology: The research method is discretional, scaling – correlation. The volume of the statistical universe in this research includes all customers in Gorgan fast foods. The statistical sample of study consist of 384 persons which are selected by kerjesi and Morgan table and the sampling method was simply coincidental. Using standard questionnaires were gathered the data research by library and field method. Results: According to Kronbach method are confirmed stability of questionnaires and the contextual method by the fluency of tools. Also, foe analysis data was utilized structural equations model method by Lisler software. Conclusion: The results of a survey show that among all variables, there is a meaningful relation between delightful and useful values with behavioral ideas and customer satisfaction in Gorgan fast foods.
Investigating the relationship between organizational communications and crisis management in Agricultural Jihad Organization of North Khorasan
Authors: Arabi Hakime , Soleimanpour Omran Mahbube 
Published: March 2022

The aim of this study is to examine the relationship between organizational communications and crisis management in Agricultural Jihad Organization of North Khorasan. Methodology: The research method is descriptive-survey and correlational, which based on Taylor-Davis model, studied the relationship between the components of speed, accuracy, validity, comprehensiveness, completeness, feedback and communication channels with crisis management. The statistical population consists of the entire staff and experts in Agricultural Jihad Organization of North Khorasan and subsidiary towns which amounts to 760 people. Out of this number, 260 individuals were selected as sample, based on Morgan's table using simple random sampling. Data collection tool for the measurement of statistical population of the study includes 760 employees in Agricultural Jihad Organization of North Khorasan. Appropriate sample including 260 individuals was selected using Cochran formula and simple random sampling, and organizational communications and crisis management were investigated using a researcher-made questionnaire. Also, Cronbach's alpha with a correlation coefficient of 95% was applied. In order to analyze the data, descriptive statistics including statistical indices (drawing table of frequency, frequency percentage, graphs) and also inferential statistics (horizontal tables, Pearson correlation test and Friedman test) was used. Results: The results show that given the estimated level of significance which is 5%, the correlation concerning the relationship between organizational communications and crisis management in Agricultural Jihad Organization of North Khorasan is equal to 0.698. Consequently, there is a relationship between them. Conclusion: The results show that organizational communications play an important role in the effectiveness of crisis management.
The relationship between cash flow forecast and earnings management in firms
Authors: Hemati Hoda , Hajiha Zohreh , Durandish Hassan 
Published: March 2022

The vast area of managers' authority and their different activities and utilizing realization and adjustment principles and using estimation, and forecasting are among factors that affect earnings' quality. Methodology: The present research has three hypotheses. First hypothesis: by presenting cash flow forecast, earnings management will decrease through earnings' elements. Second hypothesis: by presenting cash flow forecast, real activities' earnings management will increase. Third hypothesis: by presenting cash flow forecast, expectations' management will increase towards target earnings. The time period for this research was 8 years (from early 2004 to late 2011). Firms investigated in this research were 115 firms. By analyzing the collected data, we dealt with studying and testing research hypotheses. Results: Results of analyses showed that on the whole the first and second research hypotheses were approved and the third research hypothesis was rejected. Based on findings in this research it can be suggested to investors in Tehran Stock Exchange to rely on firms the present their cash flows and it can be shown that the earnings presented show firms' real earnings. The investors and creditors should pay more attention to firms' cash flow because it is one of managers' control tools to reduce earnings management. The investors should consider the factors and real signs of real earnings management and pay attention to their effects on cash flows as an index of firm's performance when they are making decisions to invest in firms. Regarding that real earnings' management discovering is done by auditors with much difficulty, it is suggested that Iranian Official Accountants' assembly and auditing organization, as active agents in accounting field in the country, should inform firms under investigations about future outcomes of earnings management through manipulating real activities, by training their own auditors. Stock Exchange Organization should introduce those firms that tend towards real earnings management by an appropriate informing format to investors and potential investors and let them invest or refuse investment consciously and based on their own short-term and long-term goals in such companies. Conclusion: Obligating firms enlisted in Stock Exchange to present cash flow forecasts results in increasing information transparency and increasing qualitative levels of researches.
The relationship of accruals and assets growth with return and risk level of companies listed in Tehran Stock Exchange
Authors: Hajiha Zohreh , Durandish Hassan , Hemati Hoda 
Published: March 2022

This paper addressed finance and behavioral finance theories including capital assets pricing and arbitrage theory. Methodology: In addition, the relationship of the growth of assets and accruals with the financial performance of the firms listed in the Tehran Stock exchange over 2008-2013 was explored. The results showed that the growth of assets and abnormal returns has a relatively strong relationship with abnormally fluctuated shares. Results: It was also found that returns on accruals are more strongly influenced by the group with highly abnormal fluctuations than by group with low abnormal fluctuations. In addition, results are similar when the size is controlled. Conclusion: These findings suggest that the negative correlation found between accruals and abnormal returns are mostly attributable to shares that have unusually high fluctuations.
Effects of Inflation and Employment Inverse on Economic Growth in Iran (1992-2012)
Authors: Mohseni Mehrnoosh , Jouzaryan Feizolah 
Published: March 2022

This study attempted to explore the role of inflation and unemployment inverse on the Iranian economic growth during 1992-2012. Methodology: Moreover, the effects of inflation and unemployment inverse on economic development were examined within short and long term periods through an autoregressive distributed lag (ARDL) model. The model was assessed through Microfit 4.0 and Eviews 6. Results: The results indicated that inflation and unemployment inverse left a negative impact on the long-term economic growth. It implies that inflation and unemployment inverse in the long-run led to lower economic growth, which can more than ever propel the Iranian authorities to pay greater attention to the importance of inflation, unemployment and devising new plans for mitigation of the two trends. Conclusion: The results can be employed by all Iranian officials, especially those involved in economic and social institutions and organizations, so as to take measures for mitigation of inflation and enhancement of employment rate, and eventually realize maximum economic growth.
Relation between financial information disclosure and capital structure decisions
Authors: Mortahan Hamid Reza , Talebnia Ghodrat Allah 
Published: March 2022

The main aim of the present study is to relation between finansial information disclosure and capital structure decisions in companies listed on Tehran Stock Exchange. Methodology: Statistical population of this study is consisted of companies listed on Tehran Stock Exchange during the time period of 2009 to 2014 and sample volume is equal to 118 companeis by using screening method and after the elimination of outlaying observations. In this study rating of information including rating of regulations compliance, rating of timely financial disclosure, rating of financial forecasts disclosure, rating of annual financial reports disclosure and rating of company website disclosure were taken as independent variables in order to study their effect on capital structure decisions. Results: This study is an applied study in terms of goal, in terms of nature and content it is a descriptive - correlation study and in terms of research design, it is an ex post facto (semi-empirical) study, which means, it is conducted on the basis of historical and past data analysis (financial statements of companies). In this study, in which panel data with fixed and random effects are used, results obtained from firm data analysis by using multivariate regression at 95% indicated that there is a direct relationship between rating of timely financial disclosures, rating of financial forecasts disclosure and rating of annual financial reports disclosure with capital structure decisions. Conclusion: It was also indicated that there is no significant relationship between rating of regulations compliance and rating of company web site disclosure with capital structure decisions of a company.
The relationship between the use of ICT with organizational health and employee empowerment mediator branches of Melli Bank of Golestan province
Authors: Farkhondeh Aynaz , Samiee Roohallah 
Published: March 2022

The aim of this study was to investigate the relationship between information technology and communication with the organizational health role of mediator empowerment Melli Bank branches in Golestan province. Methodology: The research methodology was descriptive, correlational research is survey. The target population included all employees of the Melli Bank of Golestan province is 700 people. The sample proportional to the number of people using Morgan table 248 and stratified random sampling method was selected. The data were collected by library and field methods and tools used standard questionnaires. The reliability of the questionnaire using Cronbach and validity have been confirmed by the content. In order to analyze the data, structural equation modeling using LISREL software is used. Results: The results show that the organizational health role of mediator between the ICT empowerment branches of Melli Bank of Golestan province there is a significant relationship. Conclusion: It can be concluded that significant coefficients are obtained. In other words, the quality of information and communication technology has a significant and positive relationship with empowerment.
The effect of relational benefits on customer perceived value among customers Sabah Dairy Company in Golestan Province
Authors: Sadeghlo Reza , Sorayai Ali 
Published: March 2022

The aim of this study was to evaluate the effect of relational benefits on customer perceived value among customers Sabah Dairy Company in Golestan province. Methodology: The research method is descriptive correlation is considered. The target population included all dairy customers Sabah in Golestan province of 100,000 people. The sample proportional to the number of people using Morgan table is 384. And random sampling method was simple. Library and field research data was gathered using a standardized questionnaire was used tools. The reliability of the questionnaire using Cronbach and validity were confirmed by content. The structural equation modeling to analyze the data using LISREL software was used. Results: The results showed that the relationship between the benefits to the customer's perceived value among customers Sabah Dairy Company in Golestan province, there is a significant relationshipr. Conclusion: So it can be concluded that the benefits of customer relationship on perceived value and significant positive effect. The first hypothesis is confirmed.