bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing safe and personalised maternity and neonatal care through a pandemic: a case study of outcomes and experiences in two Trusts in England using the ASPIRE COVID-19 framework
Authors: Neal Sarah , Stone Lucy , Moncrieff Gill , Matthews Zoe , Kingdon Carol , Topiladou Anastasia , Balaam Marie-Claire , Cordey Sarah , Crossland Nicola , Feeley Claire , Powney Deborah , Sarian Arni , Fenton Alan , Heazell Alexander , de Jonge Ank , Severns Alexandra , Thomson Gill , Downe Soo 
Published: September 2022

Abstract
Background:
The COVID-19 pandemic has resulted in profound and far-reaching impacts on maternal and newborn care and outcomes. As part of the ASPIRE COVID-19 project, we describe processes and outcome measures relating to safe and personalised maternity care in England.
Methods:
We undertook a mixed-methods system-wide case study using quantitative routinely collected data and qualitative data from two Trusts and their service users. We mapped findings to our prior conceptual framework that explains pathways for the impact of COVID-19 on safe and personalised care.
Results:
The ASPIRE framework enabled us to develop a comprehensive, systems-level understanding of the impact of the pandemic on service delivery, user experience and staff wellbeing, and place it within the context of pre-existing challenges. However, timely routine clinical and staffing data were not always available. Personalised care and user and staff experiences were poorly captured by routine data.
Maternity services experienced some impacts on core service coverage, though not on Trust level clinical health outcomes (with the possible exception of readmissions in one Trust). Both users and staff found some pandemic-driven changes challenging such as remote or reduced antenatal and community postnatal contacts, and restrictions on companionship. Other key changes included an increased need for mental health support, changes in the availability and uptake of home birth services and changes in induction procedures. Many emergency adaptations persisted at the end of data collection. Differences between the Trusts indicate complex change pathways. Staff reported some removal of bureaucracy, which allowed greater flexibility.
During the first wave of COVID-19 staffing numbers increased, resolving some pre-pandemic shortages: however, by October 2021 they declined markedly. Trying to maintain the quality and availability of services had marked negative consequences for personnel.
Conclusions:
The COVID-19 crisis magnified pre-pandemic problems, in particular, poor staffing levels. Maintaining services took a significant toll on staff wellbeing. There is some evidence that these pressures are continuing. There was marked variation in Trust responses. Lack of accessible and timely data at Trust and national levels hampered rapid insights. The ASPIRE COVID-19 framework could be useful for modelling the impact of future crises on routine care.
Treatment with Lactobacillus delbruckii inhibits hypertrophic scar fibrosis
Authors: Wu Gaofeng , Shen Kuo , Han Fu , Cheng Jing , Han Shichao , Wang Xiaolei , Xin Keke , Hu Dahai 
Published: September 2022

Abstract
Hypertrophic scar (HS) is a common complication of skin after burn wounds and is a serious fibrosis disease which lack effective treatments. Scholars have suggested that certain probiotics may significantly impact on fibrosis. Hypertrophic scar derived fibroblasts (HFBs) was treated with or without Lactobacillus delbruckii. The fibrosis was determined under in vivo and in vitro conditions. The results showed that L. delbruckii significantly decreased expression of Collagen I, Collagen III and α-SMA in hypertrophic scar derived fibroblasts (HFBs). Masson and Sirius-red staining results indicated that L. delbruckii significantly reduced both Collagen I and Collagen III expression and inhibited scar hyperplasia in rabbit ear model and L. delbruckii inhibited the proliferation of HFBs. To further assess the mechanism of L. delbruckii inhibit hypertrophic scar fibrosis, ribonucleic acid sequencing and iTRAQ technology was used to analysis HFBs treat with or without L. delbruckii. Results revealed that L. delbruckii exert its inhibiting fibrosis effect by targeting multiple pathways at both the proteome and transcriptome levels. L. delbruckii decreased the fibrosis of hypertrophic scar which may provide pharmacological evidence to aid in its clinical application.
Changes of the Aqueous Cytokine Factors Levels and Optical Coherence Tomography in serous retinal detachment secondary to retinal vein occlusion
Authors: Liu Xin , Zhang Yahan , Yong Hongfang , Zeng Shun , Zuo Ling 
Published: September 2022

Abstract
Purpose
To study the alteration of cytokine factors in aqueous humor and retinal microstructure in the formation of serous retinal detachment (SRD) secondary to retinal vein occlusion.
Methods
The subjects were 39 patients with RVO, of whom 31 patients had SRD (RVO-SRD). Spectral Domain Optical Coherence Tomography (SD-OCT) was used to measure the completeness of photoreceptor inner segment/outer segment (IS /OS) and the external limiting membrane (ELM) as well as the structure of RVO-SRD, including the height and shape of SRD. The aqueous humor was collected before intravitreal injection of Ranibizumab. The concentrations of VEGF, MCP-1, IL-8, IL-6, b-FGF and TNF-α in the aqueous humor were measured. All patients participated in the 6-month follow-up examinations, which included visual acuity, intraocular pressure, ophthalmologic examination, and SD-OCT. The time of recurrence of RVO-SRD was recorded.
Results
The formation of SRD was associated with the area of congested vein, disrupted IS /OS, ELM layers and high VEGF, MCP-1, IL-8, IL-6 levels. However, the height and shape of SRD were not relevant to any inflammatory factors. Moreover, high levels of MCP-1, IL-8 and IL-6 were found in large areas of congested veins. High levels of MCP-1 and IL-6 were observed in the patients with incomplete IS /OS and ELM. The recurrence of SRD was related to the high MCP-1 level.
Conclusion
High concentrations of cytokine factors in aqueous humor could induce vascular leakage, exacerbate the extent of macular edema, disrupt the structure of ELM and IS /OS, and develop SRD in RVO.
Information Embedding in DFRC Networks Through Chirp Waveform Diversity
Authors: Chalise Batu Krishna , Amin Moeness G. , Fabrizio Giuseppe A. 
Published: September 2022

Abstract
We consider a dual function radar communications network, and propose a waveform diversity-based approach to embed both target and scheduling data in transmitter pulses. The scheduling data of radar signal bandwidth, carrier frequency, and waveform along with the information on target detection, range, and Doppler are shared among the network radar nodes without a need for designated communication links. Scheduling and target information are encoded to bits and transmitted over the radar coherent pulse interval (CPI) using up- and down-chirps. We derive exact expressions of probability of bit error and false alarm rate for sharing scheduling and target information data between two radar nodes. The effect of different parameters and data sharing on the radar performance is analyzed and validated by computer simulations. Using the cross-ambiguity function (CAF), we show the capability of the up- and down- chirp sequence transmission scheme in reducing range sidelobes compared to the conventional transmission of only the up- (or down-) chirps. To overcome the limited data rate associated with only using two chirp waveforms, we consider orthogonal chirp division multiplexing (OCDM) and derive its CAF. We demonstrate the suitability of OCDM for high data rate radar operations by examining the mainlobe width and sidelobe levels of the zero-Doppler and zero-delay cuts of the CAF.
The influence of green human resource management practices on employee’s green creativity: The roles of green self-identity &amp; green shared vision
Authors: Qamar Rabia , Abidin Zain UL , Fayyaz Sana , Ahmad Haseeb 
Published: September 2022

Abstract
This study is purposed to examine how Green human resource management practices increase green creativity. It assesses the mediating role of employees’ green self-identity and green shared vision which was nearly unobserved in the previous studies. The paper opted for an explanatory study using the convenience sampling technique/approach. Data were gathered from the general managers and HR managers of 3-star, 4-star, and 5-star hotels of Pakistan. As they are directly involved with the implementation of “green human resource management practices. 250 questionnaires were distributed and 202 valid responses were used for data analysis through Smart PLS 3.0. The systematic findings showed that the green human resource management practices adequately affect the green creativity of employees which also mediates by green self-identity. Moreover, mediation of green shared vision was rejected by the results. This research is an addition to previous knowledge by adding the constructs i.e., green self-identity and green shared vision to measure the green creativity of employees.Current study fulfill the gap that how green self-identity and green shared vision mediates the relationship of Green HRM and green creativity. This research study offers valued practical implications to the policymakers and upper management, ensuring the obligation of employees towards the application of green human resource management practices and green creativity to accomplish environmental goals.
The mechanosensitive transmembrane receptor NRP1 transduces mechanical stress inhibition via LATS1/YAP in hypertrophic scars
Authors: Shu Bin , Li Mengzhi , Wang Peng , Li Jingting , Zhou Fei , Huang Shixin , Qi Shaohai 
Published: September 2022

Abstract
A hypertrophic scar (HS) is abnormal fibrous hyperplasia of the skin caused by excessive tissue repair in response to skin burns and trauma, which restricts physical function and impairs the quality of life of patients. Mechanobiological components play an essential role in wound healing and scar formation and can improve the efficiency therapy. Herein, we used weighted gene co-expression network analysis (WGCNA) and differentially expressed gene (DEGs) analysis to screen the neuropilin 1 (NRP1) gene which is sensitive to mechanical stress in various human cells. We confirmed that mechanical stress stimulates NRP1 expression in human HS endothelial cells. Immunostaining revealed that the expression of large tumor suppressor kinase 1 (LATS1) and yes-associated protein (YAP) is mediated by mechanical compression. We verified the effects of mechanical stress on NRP1, LATS1, and YAP expressions in pressure culture human dermal microvascular endothelial cell model and rat tail-scar model. We knocked down NRP1 using NRP1-shRNA and validated that NRP1 reduced YAP expression by regulating the YAP upstream regulator LATS1. Co-immunoprecipitation analysis indicated that NRP1 binds to YAP and that mechanical compression disrupted this binding. Collectively, our results indicated that the mechanosensitive transmembrane receptor NRP1 transduces mechanical force inhibition by inhibiting YAP expression. Strategies targeting NRP1 may promote compression therapy with optimal and comfortable pressures.
Heterogeneity in the course of suicidal ideation and its relation to suicide attempts in first-episode psychosis: a five-year prospective study
Authors: Sicotte Roxanne , Iyer Srividya N. , Lacourse Eric , Séguin Jean R. , Abdel-Baki Amal 
Published: September 2022

Abstract
Introduction
: Although the risk of suicide is high in first-episode psychosis (FEP), little is known about the course of suicidal ideation and its relation with suicide attempts. Therefore, we aimed to identify five-year trajectories of suicidal ideation and associated factors in FEP and compare how suicide attempts were distributed across these identified trajectories.
Methods
This five-year prospective study assessed suicidal ideation, suicide attempts and potentially associated factors through research interviews, chart review and coroners’ reports in 382 FEP patients [mean age = 23.53(SD = 3.61)] admitted to two five-year early psychosis services in Montreal, Canada. Trajectories were identified using a semiparametric mixture model, and associated factors with multinomial logistic regression.
Results
Three suicidal ideation trajectories were identified: low and decreasing (85.08%); early decline, then increasing (7.85%), and persistent suicidal ideation (7.07%). Suicidal ideation prior to admission (OR = 2.85,p < 0.05) and cocaine use disorder (OR = 6.78,p < 0.05) were associated with the early decline, then increasing suicidal ideation trajectory. Persons with prior suicide ideation (OR = 4.33,p < 0.05) and attempts (OR = 8.18,p < 0.001) and alcohol use disorder (OR = 3.63, p < 0.05) were more likely to belong to the persistent suicidal ideation trajectory, and to attempt suicide during follow-up.
Conclusion
Our study highlights heterogeneity in the course of suicidal ideation over five years and the importance of ongoing assessment of suicidal risk in FEP patients, particularly during periods of transition to other services and for patients who persistently report suicidal ideation, as they are likelier to engage in suicide attempts. Patients with factors associated with increased or persistent suicidal ideation trajectories should be targeted for suicide prevention interventions.
“The chameleon among diseases”
- An explorative view of sarcoidosis and identification of the consequences for affected patients and relatives using qualitative interviews
Authors: Hilker Charlotte , Weis Johanna , Ziehfreund Stefanie , Arkema Elizabeth V. , Biedermann Tilo , Zink Alexander 
Published: September 2022

Abstract
Introduction: Sarcoidosis is a multisystemic disease, with the lungs being the main site of manifestation. Although the exact etiology remains unclear, both genetic and environmental factors are being discussed. Diagnostic evaluation is challenging, and the management of chronic patients and assessment of their needs proves difficult, especially in the absence of targeted therapy. Studies on sarcoidosis patients have shown that quality of life is limited even after clinically measurable parameters have resolved. The question remains how patients and their relatives perceive medical care and the diagnostic process and how these affect their well-being.
Methods: Qualitative, semi-structured interviews were conducted with patients and their relatives between September 2019 and February 2020. Interviews were recorded, transcribed verbatim, and analyzed using qualitative content analysis. Deductive hypotheses were then formed based on categories according to personal aspects, symptoms, diagnostic, daily life activity, therapy, psychological aspects and wishes.
Results: Fourteen patients and five relatives were included. Most patients reported subacute symptoms before the first organ-related episode. A high degree of personal initiative was required from the majority of respondents in both the diagnostic and subsequent therapeutic processes. In addition, respondents reported so-called "doctor-hopping", a lack of specialists or contacts, and a lack of medical support. The Internet and self-help groups played a fundamental role for patients and relatives in exchanging information with other affected persons and to compensate for an existing information deficit.
Conclusion: The results provide new insights into patients’ and relatives' perceptions of the sarcoidosis diagnosis and treatment process. Identification of barriers such as a lack of physicians and an information deficit highlights potential targets for strategies to optimize sarcoidosis management.
The more slack resources, the better the quality of medical care? The evidence from the public hospitals in Beijing
Authors: Zhu Junli , Song Xinrui 
Published: September 2022

Abstract
Background: In recent years, the scale of Chinese hospitals and the resources they occupy are in a situation of rapid expansion. Whether these resources can be fully and effectively used and whether they are conducive to the improvement of the quality of medical care remains to be studied.
Methods: The DEA model and the panel regression model were used to analyze the slack resources status, and to study the relationship between slack resources and the quality of medical care.
Results: First, slack in 23 hospitals was on the rise from 2015 to 2018, with significant reduction in 2019. Second, low-risk mortality increased from .014% to .003% when slack resources increased from 0 to about 0.225. However, the low-risk mortality rate increased to .086% when slack resources increased to about .577.
Conclusions: There is an inverted U-shaped curve relationship between slack resources and the quality of medical care in public hospitals in Beijing. That is, a small number of slack resources in the hospital is conducive to the improvement of the quality of medical care, but when it increase to a certain level it will have a negative impact on the quality of medical care.
Ocular Rosacea microBiome Study (ORBS). Sub-microbial versus antibiotic dosing of doxycycline versus placebo in treatment of symptomatic ocular rosacea: study protocol for a parallel-arm randomized clinical trial
Authors: Mahmud Hamidah , Keenan Jeremy D. , Gonzales John , Schallhorn Julie , Chan Matilda , Arnold Benjamin , Cavallino Victoria , Lietman Thomas M. , Doan Thuy , Seitzman Gerami D. 
Published: September 2022

Abstract
Background
Ocular rosacea is common and is often managed with long-term antibiotic treatment. Doxycycline is the most commonly selected antibiotic for the treatment of rosacea. As there is no established standard of care treatment dose for rosacea, prescribed doses of doxycycline vary widely. The FDA classifies 40 mg daily dose of doxycycline for ocular rosacea as sub-microbial in comparison to an antibiotic dose of 200 mg daily. However, this “sub-microbial” dose has never been evaluated in patients with ocular rosacea, and even the sub-microbial dose has potential to alter systemic mucosa flora. Here, we present a randomized controlled trial using RNA sequencing to fully characterize the impact of sub-microbial antibiotic dosing of doxycycline on antimicrobial resistance and bacterial composition of the ocular and gut flora.
Methods
In a triple-masked parallel randomized control trial, patients with ocular rosacea will be distributed to three arms: a 40 mg dose of doxycycline, a 200 mg antibiotic dose of doxycycline, or placebo. Collected rectal and lower eyelid samples will be compared for frequency of antimicrobial resistance genetic determinants and microbiome diversity. A subjective ocular surface disease index survey and objective tear breakup time measurement will be determined.
Discussion
These results will enhance our understanding of the overall systemic impact of long term systemic sub-microbial antibiotic dosing for the treatment of chronic recurrent ocular inflammatory diseases.
Trial registration:
This trial was registered on clinicaltrials.org (NCT05296837) on March 22, 2022.
Economic Openness, Institutional Quality and Economic Growth in Nigeria.
Authors: Adetokunbo Abiodun , Iddey Yusuf 
Published: September 2022

Abstract
Economic openness has been argued to be an enabler of growth when supported with appropriate policies. This study investigates the effects of economic openness on economic growth in Nigeria. It also assesses the role of institutions in enabling the relationship between economic openness and economic growth. Using annual series, vector error correction model and causality test, the study shows that economic openness have positive but insignificant effect on economic growth. With the inclusion of institutional quality, the relationship between economic (trade and financial) openness and economic growth shows weak significance, however with negative effect. The implication of these findings is that activities put in place to ensure free flow of goods and services and capital inflows have not contributed significantly to economic growth. Furthermore, efforts to ensure government effectiveness have not fully translated into ensuring improved economic growth and current quality of institution might not necessarily ensure a stronger economic openness-economic growth nexus. The study recommends improved flows of goods and services with special focus on import reduction and export promotion and also recommends the promotion of stronger and quality institutions that is able to make relevant trade and financial liberalization policies that will not distort but improve economic growth significantly.
Consistent Comparison of Symptom-based Methods for COVID-19 Infection Detection
Authors: Rufino Jesús , Ramirez Juan , Baquero Carlos , Champati Jaya , Frey Davide , Lillo Rosa , Anta Antonio Fernandez 
Published: September 2022

Abstract

Multiple COVID-19 diagnosis methods based on information collected from patients have been proposed during the global pandemic crisis, with the aim of providing medical staff with quick diagnosis tools to efficiently plan and manage the limited healthcare resources. In general, these methods have been developed to detect COVID-19 positive cases from a particular combination of reported symptoms, and have been evaluated using datasets extracted from different studies with different characteristics. On the other hand, the University of Maryland, in partnership with Facebook, launched the Global COVID-19 Trends and Impact Survey (UMD-CTIS), the largest health surveillance tool to date that has collected information from 114 countries/territories since April 2020. This survey captured various individual features including gender, age groups, self-reported symptoms, isolation measures, and mental health status, among others. In this paper, we compare the performance of different proposed COVID-19 diagnosis methods using the information collected by UMD-CTIS, for the years 2020 and 2021, in five countries: Brazil, Canada, Germany, Japan, and South Africa. The evaluation of these methods with homogeneous data across countries and years provides a solid and consistent comparison among them.
Short-term outcomes of catheter-related bloodstream infection in patients admitted to the emergency department: a single-center retrospective study
Authors: Ahn Hyun Min , Kim June-sung , Park Min Gul , Hwang Jeongeun , Kim Won Young , Seo Dong Woo 
Published: September 2022

Abstract
Central line-related bloodstream infection (CRBSI) is a common complication during hospital admissions; however, there is insufficient data regarding CRBSI in the emergency department. Therefore, we evaluated the incidence and clinical impact of CRBSI using a single-center retrospective study to analyze medical data of 2189 adult patients (median age: 65 years, 58.8% males) who underwent central line insertion in ED from 2013 to 2015. CRBSI was defined if the same pathogens were identified at peripheral and catheter tips or the differential time to positivity was > 2 hours. CRBSI-related in-hospital mortality and risk factors were evaluated. CRBSI occurred in 80 patients (3.7%), of which 51 survived and 29 died; those with CRBSI had higher incidence of subclavian vein insertion, and retry rates. Staphylococcus epidermidis was the most common pathogen, followed by Staphylococcus aureus, Enterococcus faecium, and Escherichia coli. Using multivariate analysis, we found that CRBSI development was an independent risk factor for in-hospital mortality (adjusted odds ratio: 1.93, 95% confidence intervals: 1.19–3.14, p < 0.01). Therefore, CRBSI after central line insertion in the emergency department is fairly common and associated with poor outcomes. Infection prevention and management measures to reduce CRBSI incidence are essential to improve clinical outcomes.