bluuebunny/crossref_metadata_2025_split huggingface dataset:
The WASA core catalogue of Late Quaternary depositional sequences in the central Wadden Sea – A manual for the core repository
Authors: Capperucci Ruggero M. , Bartholomä Alexander , Bungenstock Friederike , Enters Dirk , Karle Martina , Wehrmann Achim 
Published: February 2022

Abstract
The reconstruction of submerged palaeolandscapes and detection of settling surfaces along coastal zones became a major research topic within the last two decades. In this context, the WASA project made use of a multidisciplinary approach for defining the extension and describing the characteristics of the Late Pleistocene to Holocene deposits in the central Wadden Sea region. In addition to sub-bottom transects, more than 140 sediment cores were taken in such an area for stratigraphic reconstruction, making use of multi-proxy analysis. To harmonize these data with the existing regional core database (LBEG archive) a new core catalogue was developed, that allows the identification of the local Late Quaternary sedimentary sequences and their characteristic facies. The WASA core catalogue has been successfully applied for reviewing the published data about the stratigraphic sequence of the Wadden Sea, for a better definition in terms of stratigraphic sequences and spatial extent of the Quaternary geological evolution of the region, and for a detailed reconstruction of the coastal palaeoenvironments.
Effects of folic acid and riboflavin on growth performance, nutrient digestion and rumen fermentation in Angus bulls
Authors: Wang Cong , Zhang Jing , Guo Gang , Huo Wenjie , Xia Cheng Qiang , Chen Lei , Zhang Yawei , Pei Caixia , Liu Qiang 
Published: February 2022

AbstractThis study examined the influences of coated folic acid (CFA) and coated riboflavin (CRF) on bull performance, nutrients digestion and ruminal fermentation. Forty-eight Angus bulls based on a randomised block and 2 × 2 factorial design were assigned to four treatments. The CFA of 0 or 6 mg of folic acid/kg DM was supplemented in diets with CRF 0 or 60 mg riboflavin (RF)/kg DM. Supplementation of CRF in diets with CFA had greater increase in daily weight gain and feed efficiency than in diets without CFA. Supplementation with CFA or CRF enhanced digestibility of DM, organic matter, crude protein, neutral-detergent fibre and non-fibre carbohydrate. Ruminal pH and ammonia N content decreased and total volatile fatty acids concentration and acetate to propionate ratio elevated for CFA or CRF addition. Supplement of CFA or CRF increased the activities of fibrolytic enzymes and the numbers of total bacteria, protozoa, fungi, dominant fibrolytic bacteria and Prevotella ruminicola. The activities of α-amylase, protease and pectinase and the numbers of Butyrivibrio fibrisolvens and Ruminobacter amylophilus were increased by CFA but were unaffected by CRF. Blood concentration of folate elevated and homocysteine decreased for CFA addition. The CRF supplementation elevated blood concentrations of folate and RF. These findings suggested that CFA or CRF inclusion had facilitating effects on performance and ruminal fermentation, and combined addition of CFA and CRF had greater increase in performance than CFA or CRF addition alone in bulls.
The Ghent altarpiece after World War II: Restitution, restoration, and redemption
Authors: Graham Jenny 
Published: February 2022

AbstractFew Old Master paintings possess as turbulent an object history as the Ghent altarpiece, now restored, since World War II, to the city’s cathedral for which it was made. While most accounts focus on the longue durée perspective, especially the work’s looting by Napoleon and Hitler, this article examines the altarpiece’s history following its return to Belgium in 1945. The altarpiece was subject to increased sensitivity at home after its wartime wanderings, and a major controversy ensued when the government backed a radical conservation project, which took place under the direction of Paul Coremans at the Royal Museum in Brussels between 1950 and 1951. The project served to emphasize the rift between north and south in Belgium in the newspaper press and became a focus for the international community as it battled to establish new standards in art restoration in the aftermath of the war.
Back to futures
Authors: PRUIKSMA KLAAS , PFENNING FRANK 
Published: February 2022

Abstract
Common approaches to concurrent programming begin with languages whose semantics are naturally sequential and add new constructs that provide limited access to concurrency, as exemplified by futures. This approach has been quite successful, but often does not provide a satisfactory theoretical backing for the concurrency constructs, and it can be difficult to give a good semantics that allows a programmer to use more than one of these constructs at a time. We take a different approach, starting with a concurrent language based on a Curry–Howard interpretation of adjoint logic, to which we add three atomic primitives that allow us to encode sequential composition and various forms of synchronization. The resulting language is highly expressive, allowing us to encode futures, fork/join parallelism, and monadic concurrency in the same framework. Notably, since our language is based on adjoint logic, we are able to give a formal account of linear futures, which have been used in complexity analysis by Blelloch and Reid-Miller. The uniformity of this approach means that we can similarly work with many of the other concurrency primitives in a linear fashion, and that we can mix several of these forms of concurrency in the same program to serve different purposes.
Declarative Learning, Priming, and Procedural Learning Performances comparing Individuals with Amnestic Mild Cognitive Impairment, and Cognitively Unimpaired Older Adults
Authors: De Wit Liselotte , Kessels Roy P.C. , Kurasz Andrea M. , Amofa Priscilla , O’Shea Deirdre , Marsiske Michael , Chandler Melanie J. , Piai Vitoria , Lambertus Taylor , Smith Glenn E. 
Published: February 2022

AbstractObjective:While declarative learning is dependent on the hippocampus, procedural learning and repetition priming can operate independently from the hippocampus, making them potential targets for behavioral interventions that utilize non-declarative memory systems to compensate for the declarative learning deficits associated with hippocampal insult. Few studies have assessed procedural learning and repetition priming in individuals with amnestic mild cognitive impairment (aMCI).Method:This study offers an overview across declarative, conceptual repetition priming, and procedural learning tasks by providing between-group effect sizes and Bayes Factors (BFs) comparing individuals with aMCI and controls. Seventy-six individuals with aMCI and 83 cognitively unimpaired controls were assessed. We hypothesized to see the largest differences between individuals with aMCI and controls on declarative learning, followed by conceptual repetition priming, with the smallest differences on procedural learning.Results:Consistent with our hypotheses, we found large differences between groups with supporting BFs on declarative learning. For conceptual repetition priming, we found a small-to-moderate between-group effect size and a non-conclusive BF somewhat in favor of a difference between groups. We found more variable but overall trivial differences on procedural learning tasks, with inconclusive BFs, in line with expectations.Conclusions:The current results suggest that conceptual repetition priming does not remain intact in individuals with aMCI while procedural learning may remain intact. While additional studies are needed, our results contribute to the evidence-base that suggests that procedural learning may remain spared in aMCI and helps inform behavioral interventions that aim to utilize procedural learning in this population.
Earth and Space Science Informatics Perspectives on Integrated, Coordinated, Open, Networked (ICON) Science
Authors: Hills D. J. , Damerow J. E. , Ahmmed B. , Catolico N. , Chakraborty S. , Coward C. M. , Crystal‐Ornelas R. , Duncan W. D. , Goparaju L. N. , Lin C. , Liu Z. , Mudunuru M. K. , Rao Y. , Rovetto R. J. , Sun Z. , Whitehead B. P. , Wyborn L. , Yao T. 
Published: February 2022

AbstractThis article is composed of three independent commentaries about the state of Integrated, Coordinated, Open, Networked (ICON) principles (Goldman, et al., 2021b, https://doi.org/10.1029/2021EO153180) in Earth and Space Science Informatics (ESSI) and includes discussion on the opportunities and challenges of adopting them. Each commentary focuses on a different topic: (Section 2) Global collaboration, cyberinfrastructure, and data sharing; (Section 3) Machine learning for multiscale modeling; (Section 4) Aerial and satellite remote sensing for advancing Earth system model development by integrating field and ancillary data. ESSI addresses data management practices, computation and analysis, and hardware and software infrastructure. Our role in ICON science therefore involves collaborative work to assess, design, implement, and promote practices and tools that enable effective data management, discovery, integration, and reuse for interdisciplinary work in Earth and space science disciplines. Networks of diverse people with expertise across Earth, space, and data science disciplines are essential for efficient and ethical exchanges of findable, accessible, interoperable, and reusable (FAIR) research products and practices. Our challenge is then to coordinate the development of standards, curation practices, and tools that enable integrating and reusing multiple data types, software, multi‐scale models, and machine learning approaches across disciplines in a way that is as open and/or FAIR as ethically possible. This is a major endeavor that could greatly increase the pace and potential of interdisciplinary scientific discovery.
Quasi‐Trapped Electron Fluxes Induced by NWC Transmitter and CRAND: Observations and Simulations
Authors: Liu Yangxizi , Xiang Zheng , Ni Binbin , Li Xinlin , Zhang Kun , Fu Song , Gu Xudong , Liu Jiang , Cao Xing 
Published: February 2022

AbstractSignals from the NWC ground‐based very low frequency (VLF) transmitter can leak into the magnetosphere and scatter trapped energetic electrons into drift loss cones. Recent studies also suggest that cosmic ray albedo neutron decay (CRAND) is probably an important source for quasi‐trapped electrons in the inner belt. To investigate their relative contributions, this study comprehensively analyzes the long‐term variations of quasi‐trapped 206 keV electrons at L = 1.7, which is roughly the L shell where NWC is located. Furthermore, a drift‐diffusion‐source model is used to reproduce longitudinal distributions of quasi‐trapped electrons and investigate sensitivities of simulation results to VLF transmitter intensities. These results suggest that CRAND is the main source of quasi‐trapped hundreds of keV electrons when the NWC station is at dayside. In contrast, pitch angle diffusions become the main source mechanism of these quasi‐trapped electrons when the NWC station operates at nightside with more VLF transmitter energy leaking into the magnetosphere.
Classification of Infrasonic Atmospheric Events Using Electromagnetic Pulse Analysis
Authors: Kahlon Maayan , Lipshtat Azi , Price Colin , Weiss Anthony 
Published: February 2022

AbstractThe Comprehensive Nuclear‐Test‐Ban Treaty Organization (CTBTO) operates the international monitoring system (IMS), consisting of four complementary technologies: Seismic, hydroacoustic, infrasound, and radionuclide, to detect events that might indicate a treaty violation. Infrasound is the main technology aimed at detecting atmospheric nuclear explosions. However, there are many other sources of infrasound signals, which are low frequency inaudible sound‐waves in the atmosphere, that are detected. To deny that the source is of a nuclear nature, requires a lot of resources. As opposed to most other sources of infrasound, nuclear explosions also emit an electromagnetic pulse (EMP). Thus, if an infrasonically detected event is not accompanied by an EMP, it is certain that it has not originated from a nuclear explosion. In this research we use electromagnetic data recorded by a single antenna to examine coincidence of infrasonically detected events with detected EMPs. We show that a large fraction of infrasonically detected events are not accompanied by any EMP and thus the need to analyze them in the context of the IMS is eliminated. For those infrasonically detected events that do coincide with EMPs, we use machine learning techniques to classify the EMPs as either lightning or a potential explosion. We show that one can identify the lightning out of the EMPs. By filtering out all lightning signals one can almost always verify that there is no EMP other than lightning, which coincided with the infrasonically detected event. This way we can dramatically reduce the number of infrasound signals which require manual analysis.
Physical Interpretation of Time‐Varying StorAge Selection Functions in a Bench‐Scale Hillslope Experiment via Geophysical Imaging of Ages of Water
Authors: Meira Neto Antônio Alves , Kim Minseok , Troch Peter A. 
Published: February 2022

AbstractUnderstanding transit times (TT) and residence times (RT) distributions of water in catchments has recently received a great deal of attention in hydrologic research since it can inform about important processes relevant to the quality of water delivered by streams and landscape resilience to anthropogenic inputs. The theory of transit time distributions (TTD) is a practical framework for understanding TT of water in natural landscapes but, due to its lumped nature, it can only hint at the possible internal processes taking place in the subsurface. While allowing for the direct observation of water movement, Electrical Resistivity Imaging (ERI) can be leveraged to better understand the internal variability of water ages within the subsurface, thus enabling the investigation of the physical processes controlling the time‐variability of TTD. In this study, we estimated time‐variable TTD of a bench‐scale bare‐soil sloping soil lysimeter through the StorAge Selection (SAS) framework, a traditional lumped‐systems method, based on sampling of output tracer concentrations, as well as through an ERI SAS one, based on spatially distributed images of water ages. We compared the ERI‐based SAS results with the output‐based estimates to discuss the viability of ERI at laboratory experiments for understanding TTD. The ERI‐derived images of the internal evolution of water ages were able to elucidate the internal mechanisms driving the time‐variability of ages of water being discharged by the system, which was characterized by a delayed discharge of younger water starting at the highest storage level and continuing throughout the water table recession.
Seeing is believing
Authors: Krasikov Sergey , Kivshar Yuri 
Published: February 2022

AbstractBound states in the continuum are realized in many optical systems as “dark states”, and their presence can be detected in the regime of leaky modes via resonances in far-fields. Here the authors reveal previously unseen structure of bound states in the continuum by exploring strong near-field localization in dielectric metasurfaces.
Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma
Authors: Xi Yiyi , Lin Yuan , Guo Wenjia , Wang Xinyu , Zhao Hengqiang , Miao Chuanwang , Liu Weiling , Liu Yachen , Liu Tianyuan , Luo Yingying , Fan Wenyi , Lin Ai , Chen Yamei , Sun Yanxia , Ma Yulin , Niu Xiangjie , Zhong Ce , Tan Wen , Zhou Meng , Su Jianzhong , Wu Chen , Lin Dongxin 
Published: February 2022

AbstractThis study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced stages has <30% five-year survival rate. Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues, we identified 35,577 differentially methylated CpG sites (DMCs) and characterized their distribution patterns. Integrating whole-genome DNA and RNA-sequencing data of the same samples, we found multiple dysregulated transcription factors and ESCC-specific genomic correlates of identified DMCs. Using featured DMCs, we developed a 12-marker diagnostic panel with high accuracy in our dataset and the TCGA ESCC dataset, and a 4-marker prognostic panel distinguishing high-risk patients. In-vitro experiments validated the functions of 4 marker host genes. Together these results provide additional evidence for the important roles of aberrant DNA methylations in ESCC development and progression. Our DMC-based diagnostic and prognostic panels have potential values for clinical care of ESCC, laying foundations for developing targeted methylation assays for future non-invasive cancer detection methods.
Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress
Authors: Brivio Paola , Audano Matteo , Gallo Maria Teresa , Gruca Piotr , Lason Magdalena , Litwa Ewa , Fumagalli Fabio , Papp Mariusz , Mitro Nico , Calabrese Francesca 
Published: February 2022

AbstractStress is the foremost environmental factor involved in the pathophysiology of major depressive disorder (MDD). However, individual differences among people are critical as some people exhibit vulnerability while other are resilient to repeated exposure to stress. Among the others, a recent theory postulates that alterations of energy metabolism might contribute to the development of psychopathologies. Here we show that the bioenergetic status in the ventral hippocampus (vHip), a brain subregion tightly involved in the regulation of MDD, defined the development of vulnerability or resilience following two weeks of chronic mild stress. Among the different metabolomic signatures observed, the glycolysis and tricarboxylic acid cycle may be specifically involved in defining vulnerability, revealing a previously unappreciated mechanism of sensitivity to stress. These findings point to mitochondrial morphology and recycling as critical in the ability to cope with stress. We show that vulnerable rats favor mitochondrial fusion to counteract the overproduction of reactive oxidative species whereas resilient rats activate fission to guarantee metabolic efficiency. Our results indicate that the modulation of the energetic metabolite profile in vHip under chronic stress exposure may represent a mechanism to explain the difference between vulnerable and resilient rats, unraveling novel and promising targets for specific therapeutic interventions.
High-mobility hydrogenated polycrystalline In2O3 (In2O3:H) thin-film transistors
Authors: Magari Yusaku , Kataoka Taiki , Yeh Wenchang , Furuta Mamoru 
Published: February 2022

AbstractOxide semiconductors have been extensively studied as active channel layers of thin-film transistors (TFTs) for electronic applications. However, the field-effect mobility (μFE) of oxide TFTs is not sufficiently high to compete with that of low-temperature-processed polycrystalline-Si TFTs (50–100 cm2V−1s−1). Here, we propose a simple process to obtain high-performance TFTs, namely hydrogenated polycrystalline In2O3 (In2O3:H) TFTs grown via the low-temperature solid-phase crystallization (SPC) process. In2O3:H TFTs fabricated at 300 °C exhibit superior switching properties with µFE = 139.2 cm2V−1s−1, a subthreshold swing of 0.19 Vdec−1, and a threshold voltage of 0.2 V. The hydrogen introduced during sputter deposition plays an important role in enlarging the grain size and decreasing the subgap defects in SPC-prepared In2O3:H. The proposed method does not require any additional expensive equipment and/or change in the conventional oxide TFT fabrication process. We believe these SPC-grown In2O3:H TFTs have a great potential for use in future transparent or flexible electronics applications.
Controlling process instability for defect lean metal additive manufacturing
Authors: Qu Minglei , Guo Qilin , Escano Luis I. , Nabaa Ali , Hojjatzadeh S. Mohammad H. , Young Zachary A. , Chen Lianyi 
Published: February 2022

AbstractThe process instabilities intrinsic to the localized laser-powder bed interaction cause the formation of various defects in laser powder bed fusion (LPBF) additive manufacturing process. Particularly, the stochastic formation of large spatters leads to unpredictable defects in the as-printed parts. Here we report the elimination of large spatters through controlling laser-powder bed interaction instabilities by using nanoparticles. The elimination of large spatters results in 3D printing of defect lean sample with good consistency and enhanced properties. We reveal that two mechanisms work synergistically to eliminate all types of large spatters: (1) nanoparticle-enabled control of molten pool fluctuation eliminates the liquid breakup induced large spatters; (2) nanoparticle-enabled control of the liquid droplet coalescence eliminates liquid droplet colliding induced large spatters. The nanoparticle-enabled simultaneous stabilization of molten pool fluctuation and prevention of liquid droplet coalescence discovered here provide a potential way to achieve defect lean metal additive manufacturing.
Single-cell gene fusion detection by scFusion
Authors: Jin Zijie , Huang Wenjian , Shen Ning , Li Juan , Wang Xiaochen , Dong Jiqiao , Park Peter J. , Xi Ruibin 
Published: February 2022

AbstractGene fusions can play important roles in tumor initiation and progression. While fusion detection so far has been from bulk samples, full-length single-cell RNA sequencing (scRNA-seq) offers the possibility of detecting gene fusions at the single-cell level. However, scRNA-seq data have a high noise level and contain various technical artifacts that can lead to spurious fusion discoveries. Here, we present a computational tool, scFusion, for gene fusion detection based on scRNA-seq. We evaluate the performance of scFusion using simulated and five real scRNA-seq datasets and find that scFusion can efficiently and sensitively detect fusions with a low false discovery rate. In a T cell dataset, scFusion detects the invariant TCR gene recombinations in mucosal-associated invariant T cells that many methods developed for bulk data fail to detect; in a multiple myeloma dataset, scFusion detects the known recurrent fusionIgH-WHSC1, which is associated with overexpression of theWHSC1oncogene. Our results demonstrate that scFusion can be used to investigate cellular heterogeneity of gene fusions and their transcriptional impact at the single-cell level.
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis
Authors: Mise Shintaro , Matsumoto Akinobu , Shimada Keisuke , Hosaka Toshiaki , Takahashi Masatomo , Ichihara Kazuya , Shimizu Hideyuki , Shiraishi Chisa , Saito Daisuke , Suyama Mikita , Yasuda Tomoharu , Ide Toru , Izumi Yoshihiro , Bamba Takeshi , Kimura-Someya Tomomi , Shirouzu Mikako , Miyata Haruhiko , Ikawa Masahito , Nakayama Keiichi I. 
Published: February 2022

AbstractAlthough several long noncoding RNAs (lncRNAs) have recently been shown to encode small polypeptides, those in testis remain largely uncharacterized. Here we identify two sperm-specific polypeptides, Kastor and Polluks, encoded by a single mouse locus (Gm9999) previously annotated as encoding a lncRNA. Both Kastor and Polluks are inserted in the outer mitochondrial membrane and directly interact with voltage-dependent anion channel (VDAC), despite their different amino acid sequences. Male VDAC3-deficient mice are infertile as a result of reduced sperm motility due to an abnormal mitochondrial sheath in spermatozoa, and deficiency of both Kastor and Polluks also severely impaired male fertility in association with formation of a similarly abnormal mitochondrial sheath. Spermatozoa lacking either Kastor or Polluks partially recapitulate the phenotype of those lacking both. Cooperative function of Kastor and Polluks in regulation of VDAC3 may thus be essential for mitochondrial sheath formation in spermatozoa and for male fertility.