bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling uncertainties with TOPSIS and GRA based on q‐rung orthopair m‐polar fuzzy soft information in COVID‐19
Authors: Riaz Muhammad , Garg Harish , Hamid Muhammad Tahir , Afzal Deeba 
Published: February 2022

AbstractFuzzy hybrid models are strong mathematical tools to address vague and uncertain information in real‐life circumstances. The aim of this article is to introduce a new fuzzy hybrid model named as of q‐rung orthopair m‐polar fuzzy soft set (q‐RO‐m‐PFSS) as a robust fusion of soft set (SS), m‐polar fuzzy set (m‐PFS) and q‐rung orthopair fuzzy set (q‐ROFS). A q‐RO‐m‐PFSS is a new approach towards modelling uncertainties in the multi‐criteria decision making (MCDM) problems. Some fundamental operations on q‐RO‐m‐PFSSs, their key properties, and related significant results are introduced. Additionally, the complexity of logistics and supply chain management during COVID‐19 is analysed using TOPSIS (technique for ordering preference through the ideal solution) and GRA (grey relational analysis) with the help of q‐RO‐m‐PFS information. The linguistic terms are used to express q‐RO‐m‐PFS information in terms of numeric values. The proposed approaches are worthy efficient in the selection of ventilator's manufacturers for the patients suffering from epidemic disease named as COVID‐19. A practical application of proposed MCDM techniques is demonstrated by respective numerical examples. The comparison analysis of the final ranking computed by proposed techniques is also given to justify the feasibility, applicability and reliability of these techniques.
Enterprise credit risk prediction using supply chain information: A decision tree ensemble model based on the differential sampling rate, Synthetic Minority Oversampling Technique and AdaBoost
Authors: Yao Gang , Hu Xiaojian , Zhou Taiyun , Zhang Yue 
Published: February 2022

AbstractThe spread of enterprise credit risk in the supply chain may lead to large‐scale bankruptcy and credit crises, which are related to national economic and social stability and financial system security. Therefore, enterprise credit risk in the supply chain context is not only a concern for banking financial institutions, credit rating agencies and enterprise managers but also the focus of governments. This article develops a DTE‐DSA (decision tree [DT] ensemble model using the differential sampling rate, Synthetic Minority Oversampling Technique [SMOTE] and AdaBoost) prediction framework integrating supply chain information to predict enterprise credit risk. The empirical test shows that using supply chain information can significantly improve the prediction score. The DTE‐DSA model has the best prediction effect in dealing with class imbalance problems. Compared with single classifier models—such as logistic regression, k‐nearest neighbours, support vector machine, DT and DT using the SMOTE—as well as ensemble models—such as extremely randomized trees, random forest, rotation forest, extreme gradient boosting, gradient boosting DT and DT ensemble model using AdaBoost—the DTE‐DSA model not only has the best prediction score but also has a more stable performance. The comprehensive use of supply chain information and the DTE‐DSA model can result in the highest prediction score, with an area under the curve of 0.9016 and a Kolmogorov–Smirnov statistic of 0.7369. Further analysis of the variables of importance enhances the interpretability of the model and obtains relevant management insights.
Detecting breast cancer using novel mask R‐CNN techniques
Authors: Jahangeer Gul Shaira Banu , Thambidurai Dhiliphan Rajkumar 
Published: February 2022

AbstractBreast cancer is more common in women and the mortality rate also increases in recent days. Early detection of breast cancer is reduces the severity of the disease to some extent. Various image processing and classification techniques imposed on a particular image to detect and diagnose the breast cancer clearly. For early detection, an efficient methodology is needed. To reduce death rate, accurate discovery of the disease should be efficiently implemented. The mask R‐CNN is used for segmentation to identify abnormalities and ensemble CNN is used to classify the benign and malignant tumour from the given mammographic breast cancer image. The input is fed into the enhanced fuzzy based median filter which is used to remove speckle noises which in turn increases the clarity of images. The noise‐free images are fed into the proposed mask R‐CNN for segmentation. It is an effective framework for segmentation of medical images. The classification process is then given into ensemble based CNN classifier for prediction of mammogram images. The ensemble based CNN is proposed for the classification of mammograms as benign and malignant. The proposed method focus on the optimization which is performed to minimize the memory requirements and running time while maintaining the high performance of the classifier. The performance metrics such as accuracy, precision, f‐measure, and recall is evaluated to measure the efficacy of the proposed design. Using MIAS and DDSM dataset the performance metrics has been evaluated and compared with existing approaches. The results shows that the performance of the proposed method shows higher efficiency.
Reducing the physical, social, and emotional impact of episodic migraine: Results from erenumab STRIVE and ARISE phase III randomized trials
Authors: Kawata Ariane K. , Ladd Mary Kate , Lipton Richard B. , Buse Dawn C. , Bensink Mark , Shah Shweta , Hareendran Asha , Mannix Sally , Mikol Daniel 
Published: February 2022

AbstractObjectiveThe purpose of this study was to examine changes in the functional impact of migraine following treatment with erenumab, as measured by the Migraine Functional Impact Questionnaire (MFIQ).BackgroundThe MFIQ, a novel patient‐reported outcome (PRO) measuring the impact of migraine on four domains (physical function, social function, and emotional function [PF, SF, and EF]; usual activities [UAs]) and a single item assessing overall impact on UA, was included in phase III trials evaluating erenumab 70 and 140 mg monthly for migraine prevention among people with episodic migraine (EM).MethodsIn the ARISE study, 577 patients with EM were randomized to erenumab 70 mg or placebo. In the STRIVE study, 955 patients with EM were randomized to erenumab, 70 mg or 140 mg or placebo. Pairwise comparisons of least‐squares mean (LSM) change from baseline in MFIQ scores (with associated 95% confidence interval [CI]) were assessed for each active treatment versus placebo.ResultsIn ARISE, greater reductions from baseline to month 3 were observed for 70 mg versus placebo for PF (LSM [95% CI]: −3.2 [−6.4 to −0.1]; p = 0.046) and EF (−4.0 [−7.3 to −0.7]; p = 0.019) domain scores. In STRIVE, between‐group differences also reflected reductions from baseline to the average of months 4–6 that favored erenumab on all four MFIQ domain scores. Reductions in impact for 70 mg compared to placebo were −4.3 (95% CI: −6.8 to −1.7; p < 0.001) for PF, −4.0 (−6.3 to −1.7; p < 0.001) for UA, −3.7 (−6.1 to −1.2; p = 0.003) for SF, and −5.3 (−7.9 to −2.6; p < 0.001) for EF domain scores. Improvements were also observed for 140 mg versus placebo with between‐group differences of −5.7 (95% CI: −8.2 to −3.2; p < 0.001) in PF, −5.1 (−7.5 to −2.8; p < 0.001) in UA, −5.0 (−7.4 to −2.6; p < 0.001) in SF, and −7.2 (−9.9 to −4.5; p < 0.001) in EF domain scores. There were also greater improvements in the overall impact on UA score for 70 mg (LSM [95% CI]: −4.3 [−7.0 to −1.7]; p = 0.001) and 140 mg (−5.3 [−8.5 to −3.2]; p < 0.001) versus placebo.ConclusionsThe MFIQ measures the frequency of impacts and level of difficulty on multiple functional domains that provide a more complete picture of the effects of migraine. MFIQ scores showed that in comparison with placebo, patients treated with erenumab had greater reductions in the functional impact of migraine, providing insight into treatment benefits that extend beyond improvements in clinical status and health‐related quality of life previously reported based on clinical end points and other PROs.
Effects of morphology on the electrochemical performance of NiFe2O4nanoparticles with battery‐type behavior
Authors: Silva Maitê M. S. , Raimundo Rafael A. , Ferreira Luciena S. , Macedo Daniel A. , Morales Marco A. , Souza Carlson P. , Santos Andarair G. , Lopes‐Moriyama André L. 
Published: February 2022

AbstractWe report the synthesis of NiFe2O4nanoparticles by the complexation EDTA‐citrate method under acidic (pH = 3) and basic (pH = 9) conditions. The structural, optical, vibrational, magnetic, and electrochemical properties were studied. The samples have crystallite sizes of 21 nm (pH 3) and 73 nm (pH 9), with rounded particles and layered structures. The57Fe Mössbauer spectra at 12 K showed that both samples had an inverse spinel cation distribution. At 5 K, the sample prepared at pH 9 showed saturation magnetizations of about 50 emu/g. Raman spectra showed typical bands of NiFe2O4phase. The materials were tested as electrodes under alkaline condition. The cyclic voltammetry and charge‐discharge experiments indicated a battery‐type behavior, with maximun capacities of 65 and 5 C/g (at specific currents of 3 and 10 A/g) for samples prepared at pH 9 and 3, respectively. This work offers a route for obtaining NiFe2O4nanoparticles with different morphologies and sizes tuned by the synthesis conditions.
On temperature‐dependent interfacial fracture energy/stress intensity factor and matrix cracking in ceramic composites
Authors: Gao Fei , Li Weiguo , Zhang Xuyao , Yang Mengqing , He Yi , Dong Pan , Ma Yanli , Qu Zhaoliang 
Published: February 2022

AbstractThe first matrix cracking stress is a crucial indicator to appraise the mechanical properties of ceramic‐matrix composites, which is the starting point of permanent damage. Based on the classic energy balance method and stress intensity method, two temperature‐dependent first matrix cracking stress models of fiber‐reinforced ceramic matrix composites are established, respectively. The model established by the energy balance method considers the evolution of interfacial fracture energy with temperature, and the model established by the stress intensity method takes into account the evolution of stress intensity factor with temperature. The predictions of the above models in a wide temperature range are verified using experimental data available in the literature, which shows the rationality and accuracy of the above models. Moreover, on the basis of the energy balance method model, the main factors controlling the first matrix cracking stress at different temperatures are analyzed by the numbers. Finally, in view of the analysis results, some suggestions on how to optimize and enhance the first matrix cracking stress at different temperatures are put forward.
Effector immune cells in chronic lung allograft dysfunction: A systematic review
Authors: Bos Saskia , Filby Andrew J. , Vos Robin , Fisher Andrew J. 
Published: February 2022

AbstractChronic lung allograft dysfunction (CLAD) remains the major barrier to long‐term survival after lung transplantation and improved insight into its underlying immunological mechanisms is critical to better understand the disease and to identify treatment targets. We systematically searched the electronic databases of PubMed and EMBASE for original research publications, published between January 2000 and April 2021, to comprehensively assess current evidence on effector immune cells in lung tissue and bronchoalveolar lavage fluid from lung transplant recipients with CLAD. Literature search revealed 1351 articles, 76 of which met the criteria for inclusion in our analysis. Our results illustrate significant complexity in both innate and adaptive immune cell responses in CLAD, along with presence of numerous immune cell products, including cytokines, chemokines and proteases associated with tissue remodelling. A clear link between neutrophils and eosinophils and CLAD incidence has been seen, in which eosinophils more specifically predisposed to restrictive allograft syndrome. The presence of cytotoxic and T‐helper cells in CLAD pathogenesis is well‐documented, although it is challenging to draw conclusions about their role in tissue processes from predominantly bronchoalveolar lavage data. In restrictive allograft syndrome, a more prominent humoral immune involvement with increased B cells, immunoglobulins and complement deposition is seen. Our evaluation of published studies over the last 20 years summarizes the complex multifactorial immunopathology of CLAD onset and progression. It highlights the phenotype of several key effector immune cells involved in CLAD pathogenesis, as well as the paucity of single cell resolution spatial studies in lung tissue from patients with CLAD.
The Computer Aided Design/press technique: Fabrication of zirconia‐reinforced lithium disilicate restorations for treatment of extensive noncarious cervical lesions
Authors: Conejo Julian , Santos Telmo , Tikreeti Abdullah , Atria Pablo J. , Blatz Markus 
Published: February 2022

AbstractObjectiveThe aim of this case report is to present the CAD/Press technique; a workflow that combines digital design, milled, or 3D printed burnout molds, and a new pressable ceramic material for the treatment of extensive noncarious lesions with minimal invasive indirect ceramic restorations.Clinical ConsiderationsClinical decisions from material selection, preparation design, manufacturing techniques to adhesive protocols will be discussed, as they are important factors for achieving long‐term clinical success while preserving healthy tooth structure.Clinical SignificanceThe presented workflow aims to ease clinical decisions when restoring extensive cases with indirect restorations and show clinicians a workflow combining several techniques.
Male zebrafish (Danio rerio) do not preferentially associate with familiar over unfamiliar conspecifics
Authors: Blonder Aviva F. , Tarvin Keith A. 
Published: February 2022

AbstractMembers of several shoaling species have been shown to prefer to associate with familiar individuals, enhancing the benefits of aggregation. The authors used a series of social preference tasks in the laboratory to evaluate whether prior familiarity with potential partners influences preference of shoaling partner in male zebrafish (Danio rerio), a social species found in shallow, slow‐moving waters. The authors found that though male zebrafish exhibited a strong preference for shoaling with a male conspecific as opposed to remaining alone, they exhibited no preference for familiar over unfamiliar conspecifics. This suggests that the benefits of familiarity for shoaling behaviour may not be as important for male zebrafish as has been shown in other social fish species.
The effect of offender race/ethnicity on public opinion of appropriate criminal sentences
Authors: Forney Mia A. , Lacy Joyce W. 
Published: February 2022

AbstractPurposeThere has been a long history of sentencing disparities in the United States criminal justice system, in particular amongst defendants of different races or ethnicities. The most commonly noted disparity is that Black defendants are typically sentenced more harshly than White defendants. This study analysed the relationship between an offender's racial/ethnic status and the layperson's opinion of an appropriate sentence by investigating an array of racial/ethnic categories amongst a variety of crimes.MethodUndergraduate students (Experiment 1, N = 594; Experiment 3, N = 263) recruited from introductory psychology courses and a community sample (Experiment 2, N = 124) recruited via Amazon MTurk were presented with crime vignettes and photos of offenders and asked to assign a punishment that they deem appropriate (operationalized as number of months of imprisonment). Participants were also randomly assigned to either receive the 2018 Federal Guidelines’ recommended sentence for each crime or not.ResultsTwo findings were the most striking: 1) White offenders were sentenced significantly more harshly than any other race/ethnicity for assault crimes and 2) significant differences in sentencing due to offender race/ethnicity were only apparent when participants were exposed to all five race/ethnicity categories (Experiments 1 and 2) rather than just one race/ethnicity (Experiment 3).ConclusionsThe results of the present study may be time‐sensitive and reflective of the current sociopolitical climate following the murder of George Floyd in 2020. Future research may benefit from replicating this study longitudinally to assess the longevity of these results.
Animal experimental models of ischemic wounds – A review of literature
Authors: Lovasova Veronika , Bem Robert , Chlupac Jaroslav , Dubsky Michal , Husakova Jitka , Nemcova Andrea , Fronek Jiri 
Published: February 2022

AbstractCritical limb ischemia is a serious form of peripheral arterial disease (PAD). The consequences of lower limb ischemia are pain, claudication and chronic non‐healing wounds. Patients with diabetes are especially at a high risk for developing non‐healing ulcers. The most serious complication is major amputation. For this reason, there is a significant medical requirement to develop new therapies in order to prevent the progression of PAD. For research purposes, it is crucial to find an appropriate model of chronic ischemia to explore the processes of wound healing. According to recently acquired information, rodents are currently the most commonly used animals in these types of studies. The main advantage of using small animals is the low financial cost due to the relatively small demand for food, water and living space. The disadvantage is their anatomy, which is different from that of humans. Larger animals have a more human‐like anatomy and physiology, but they require more expense and space for housing. A bipedicle skin flap and its modifications are popular models for ischemic wounds. In order to secure healing through re‐epithelisation, as opposed to contraction in rodents, there is a need to remove the panniculus carnosus muscle. Wounds in other experimental animals heal primarily through re‐epithelisation. The application of a silicone mesh underneath the flap prevents vascular regrowth in ischemic tissue. There is an ongoing effort to create in vivo diabetic models for chronic ulcer research. This work presents an overview of existing animal models of ischemic wounds.
GABA‐ergic agents modulated the effects of histamine on the behaviour of male mice in the elevated plus maze test
Authors: Fathalizade Farzan , Baghani Matin , Khakpai Fatemeh , Fazli‐Tabaei Soheila , Zarrindast Mohammad‐Reza 
Published: February 2022

New Findings

What is the central question of this study?
Is there an interaction between histamine and the GABAergic system in modulation of anxiety in mice?

What is the main finding and its importance?
There is a synergistic anxiogenic effect between histamine and bicuculline in mice. This effect may be due to a direct or an indirect effect of the histaminergic system on the GABAergic system.

AbstractIt has been documented that both histaminergic and GABAergic systems participate in the neurobiology of anxiety behaviour. In the current research, we investigated the effects of the histaminergic system and GABAA receptor agents on anxiety‐related behaviours and their interaction using the elevated plus maze test in mice. Intraperitoneal (i.p.) administration of muscimol (0.12 and 0.25 mg/kg) increased the open arm time (OAT) (P < 0.001) without affecting the open arm entries (OAE) and locomotor activity, showing an anxiolytic effect. i.p. injection of bicuculline (0.5 and 1 mg/kg) decreased OAT (P < 0.001) but not OAE and locomotor activity, suggesting an anxiogenic behaviour. Intracerebroventricular (i.c.v.) microinjection of histamine (2.5 and 5 μg/mouse) resulted in a decline in OAT (P < 0.001) but not OAE and locomotor activity, indicating an anxiogenic response. Co‐administration of histamine with GABAergic agents, muscimol (0.06 mg/kg; i.p.) and bicuculline (0.25 mg/kg; i.p.), decreased (P < 0.001) and increased (P < 0.05), respectively, the anxiogenic‐like response to the effective dose (5 μg/mouse; i.c.v.) of histamine. In addition, co‐treatment of effective doses of histamine (2.5 and 5 μg/mouse;i.c.v.) with an effective dose of muscimol (0.12 mg/kg; i.p.) and a non‐effective dose of bicuculline (0.25 mg/kg; i.p.) significantly decreased OAT (P < 0.001), suggesting a likely interaction between the histaminergic and GABAergic systems in the regulation of anxiety. The results demonstrated a synergistic anxiogenic‐like effect between histamine and bicuculline in mice. In conclusion, our results present an interaction between the histaminergic and GABAergic systems in anxiolytic/anxiogenic‐like behaviours in the elevated plus maze test.
ZEB1 recruits BRG1 to regulate airway remodelling epithelial‐to‐mesenchymal transition in asthma
Authors: Wang Ting , Peng Bingming , Luo Tingting , Tian Daiyin , Zhao Zhihua , Fu Zhou , Li Qubei 
Published: February 2022

New Findings

What is the central question of this study?
The aim was to investigate the function of brahma‐related gene‐1 (BRG1) in airway remodelling epithelial‐to‐mesenchymal transition (EMT) of asthma and identify the transcription factor of BRG1 that binds to the protomer of E‐cadherin.

What is the main finding and its importance?
This study highlighted an important molecular mechanism involving chromatin remodelling factor BRG1 that played a crucial role in airway remodelling EMT of asthma and demonstrated that ZEB1 was the key transcription factor recruiting BRG1. This finding might offer new insights into gene‐based therapy for asthma.

AbstractEpithelial‐to‐mesenchymal transition (EMT) of airway remodelling happens in children with asthma. A reduction in the epithelial marker E‐cadherin is reported to be one of the initiating factors of EMT. Our previous study showed that chromatin remodelling factor brahma‐related gene‐1 (BRG1) could regulate the expression of E‐cadherin indirectly. However, the transcription factor involved in the recruitment of BRG1 in asthma is unknown. Here, we studied the function of Brg1 in an ovalbumin‐induced asthma model [lung‐specific conditional Brg1 knockdown (Brg1−/−) mice] and human bronchial epithelial 16HBE cells stably expressing BRG1 short hairpin RNA. Our results showed that Brg1 was involved in EMT in asthmatic mice by detecting the expression of EMT markers. We also identified that BRG1 participated in the transforming growth factor‐β‐induced EMT of 16HBE cells. We observed that zinc finger E‐box binding homeobox 1 (ZEB1) and BRG1 co‐localized in the EMT of TGF‐β‐induced 16HBE cells. Further results revealed that ZEB1 recruited BRG1 and bound to the promoter region (+3563/3715) to regulate E‐cadherin expression. Thus, ZEB1 might be the key transcription factor to recruit BRG1 in airway remodelling EMT of asthma and might be a new therapeutic target.