bluuebunny/crossref_metadata_2025_split huggingface dataset:
GSK2556286 is a novel antitubercular drug candidate effective in vivo with the potential to shorten tuberculosis treatment
Authors: Nuermberger Eric L. , Martínez-Martínez Maria Santos , Sanz Olalla , Urones Beatriz , Esquivias Jorge , Soni Heena , Tasneen Rokeya , Tyagi Sandeep , Li Si-Yang , Converse Paul J. , Boshoff Helena I. , Robertson Gregory T , Besra Gurdyal S , Abrahams Katherine A. , Upton Anna M , Mdluli Khisimuzi , Boyle Gary W , Turner Sam , Fotouhi Nader , Cammack Nicholas C. , Siles Juan Miguel , Alonso Marta , Escribano Jaime , Lelievre Joel , Pérez-Herrán Esther , Bates Robert H. , Maher-Ewards Gareth , Barros David , Ballell Lluís , Jiménez Elena 
Published: February 2022

AbstractAs a result of a high-throughput compound screening campaign of Mycobacterium tuberculosis infected macrophages, a new preclinical drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (IC50 = 0.07 µM), is active against extracellular bacteria in cholesterol-containing culture media and exhibits no cross-resistance with known antitubercular drugs. In addition, it has shown efficacy in different mouse models of tuberculosis (TB) and has an adequate safety profile in two preclinical species. These features indicate a compound with a novel mode of action, although still not fully defined, that is effective against both multidrug or extensively-resistant (M/XDR) and drug-sensitive (DS) M. tuberculosis with the potential to shorten the duration of treatment in novel combination drug regimens.One Sentence SummaryGSK2556286 is a novel preclinical drug candidate for the treatment of tuberculosis with a new mode of action potentially able to contribute to the shortening of TB chemotherapy.
The Effect of Cryo-auriculotherapy on Post-Operative Pain Management following Rotator Cuff Surgery: A Randomized, Placebo-Controlled Study
Authors: Chelly Jacques E. , Orebaugh Steven L. , Rodosky Mark W. , Groff Yram J. , Norton Brittany E. , Monroe Amy L. , Alimi David , Sadhasivam Senthilkumar K. , Vogt Keith M. 
Published: February 2022

ABSTRACTBackgroundIn the context of the current opioid crisis, there is a growing interest in evaluating non-pharmacological solutions to manage post-operative pain. Evidence supports the concept that auriculotherapy may provide significant analgesiaObjectiveInvestigating the efficacy of cryo-auriculotherapy to reduce postoperative opioid consumption following a rotator cuff surgery.SettingsAcademic medical center, USAMethodsThis trial was registered to Clinicaltrials.gov (NCT03860259). A total of 39 subjects undergoing rotator cuff surgery and randomized to receive either an active cryo-auriculotherapy treatment (Auriculotherapy; n=20) or a placebo treatment (placebo; n=19) were included in the analysis. For each cryo-auriculotherapy subject, the treatment was performed in the recovery room. The primary endpoint was overall opioid consumption (oral morphine equivalent = OME). Secondary endpoints included pain and overall non-narcotic analgesic consumption on postoperative day 5, patient satisfaction and function recovery using the 12-Item Short Form Health Survey (SF-12), time to discharge from the recovery room and the hospital and patient satisfaction, as well as the number of subjects from each group readmitted because of pain-related issues.ResultsThe use of cryo-auriculotherapy was associated with a 35% decrease in total opioid requirement over the first five-day recovery period and a 15% decrease in pain with movement. Pain with movement in the auriculotherapy group remained lower compared to the placebo group for at least 14 days (4.47 ± 2.12 vs 5.84 ± 2.39, respectively; p=0.0394).ConclusionsOur data suggests that cryo-auriculotherapy represents an alternative to opioids in patients undergoing rotator-cuff surgery.
An improved MS2-MCP imaging system with minimal perturbation of mRNA stability
Authors: Li Weihan , Maekiniemi Anna , Sato Hanae , Osman Christof , Singer Robert H. 
Published: February 2022

AbstractThe MS2-MCP imaging system is widely used to study the mRNA spatial distribution in living cells. Here, we report that the MS2-MCP system may destabilize the tagged mRNA by targeting it to the nonsense-mediated mRNA decay pathway. We introduce an improved version, which has minimal perturbation of the mRNA stability.
A Yap-dependent transcriptional program directs cell migration for embryo axis assembly
Authors: Sousa-Ortega Ana , Vazquez-Marin Javier , Sanabria-Reinoso Estefanía , Polvillo Rocío , Campoy-López Alejandro , Buono Lorena , Loosli Felix , Almuedo-Castillo María , Martinez-Morales Juan R. 
Published: February 2022

ABSTRACTThe condensation of the embryo primary axis is a fundamental landmark in the establishment of the vertebrate body plan. Although the complex morphogenetic movements directing cell convergence towards the midline have been described extensively, little is known on how gastrulating cells interpret mechanical cues. Yap proteins are among the best characterized transcriptional mechanotransducers, yet their role in gastrulation has remained elusive. Here we show that the double knockout of yap and its paralog yap1b in medaka results in an axis assembly failure. Quantitative live imaging reveals that mutant cells display reduced displacement and migratory persistence. By characterizing the Yap-dependent transcriptional program, we identified genes involved in cytoskeletal organization and cell-ECM adhesion, rather than in germ layer specification, as direct Yap targets. Dynamic analysis of Tead sensors and downstream targets reveals Yap is acting in migratory cells, and not as a midline beacon, to direct gastrulating precursors trajectories by promoting cortical actin recruitment and focal adhesions assembly. We propose that Yap is engaged in a mechano-regulatory loop that is essential to maintain the directed cell migration sustaining embryo axis formation.
Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions
Authors: Liu Yingjun , Senatore Assunta , Sorce Silvia , Nuvolone Mario , Guo Jingjing , Gümüş Zeynep H. , Aguzzi Adriano 
Published: February 2022

AbstractMammalian models are essential for brain aging research. However, the long lifespan and limited amenability to genetic and pharmacological perturbations have hindered the use of mammals for dissecting aging-regulatory molecular networks and discovering new anti-aging interventions. To circumvent these limitations, we developed an ex vivo model system that faithfully mimics the aging process of the mammalian brain using cultured mouse brain slices. Genome-wide gene expression analyses showed that brain slices spontaneously upregulated senescence-associated genes over time and reproduced many of the transcriptional characteristics of aged brains. Treatment with rapamycin, a classical anti-aging compound, largely abolished the time-dependent transcriptional changes in brain slices. Using this model system, we discovered that prions drastically accelerated the development of age-related molecular signatures and the pace of brain aging. We confirmed this finding in mouse models and human victims of Creutzfeldt-Jakob disease. These data establish a novel, eminently tractable mammalian model of brain aging, and uncover a surprising acceleration of brain aging in prion diseases.
The effect of fixed and growth mindsets on buying sustainable foods
Authors: Rahnama Hassan , Popkowski Leszczyc Peter T.L. 
Published: February 2022

PurposeFew marketing studies have studied consumer mindsets about sustainable products in developing countries. This paper examines the influence of fixed and growth mindsets on buying sustainable foods in Iran.Design/methodology/approachTo reach this goal, the authors designed a conceptual model and specified hypotheses. A non-probability survey of 622 people was conducted through a multistage cluster random sampling from two provinces in north Iran: Gilan and Mazandaran. Data were collected through a face-to-face questionnaire. A chi-square test, confirmatory factor analysis, structural equation modelling, the bootstrapping method and the PLS product-indicator approach were used for analyses.FindingsResults show that fixed and growth mindsets have a positive impact on buying sustainable foods. In addition, these two mindsets have a significant effect on consumers' health concerns and warm glow. The study demonstrates that health concerns, environmental values and convenience orientation mediate the relationship between growth mindset and sustainable shopping. However, for a fixed mindset, environmental values are not a mediator. Further, peer influence significantly moderates the effect of both mindsets and motivational variables—environmental values, convenience orientation and warm glow—on purchasing sustainable foods. This study emphasises the critical role of peer influence and motivation factors, including health concern, convenience and warm glow, on purchasing sustainable foods.Originality/valueThis research introduces a new framework concerning consumer behaviour, in particular, consumer psychology towards buying sustainable foods.
The impact of ownership structure on integrated reporting in European firms
Authors: Zouari Ghazi , Dhifi Kawther 
Published: February 2022

PurposeWithin the theoretical framework of corporate governance, the article aims to examine the impact of ownership structure on the level of disclosure of financial and non-financial information in integrated reporting (IR), and the effect is sensitive to national legal systems.Design/methodology/approachRegressions on panel data are used to study the impact of ownership structure on IR. The present empirical study was based on a sample of 431 European firms belonging to common or civil law for the period spanning 2012 and 2019.FindingsThe results of the linear regressions corroborate the existence of relationships between the ownership concentration, institutional ownership as well as managerial ownership and IR.Research limitations/implicationsThe study have limitations as follows: the role of the ownership structure studied here, the model should incorporate other internal and external control mechanisms to represent reality more fully. The mechanisms include board characteristics, financial market, labor market, the goods and services market, etc. that affect managerial latitude and, therefore, the adoption of IR. Finally, the authors will consider future theoretical and empirical improvement. For example, it would be interesting to extend the theoretical framework to the contributions of cognitive governance and to empirically examine the modeling with a larger sample of firms, including an international comparison.Originality/valueThe study provides evidence as to the disclosure of IR and ownership structure. The originality/value chapter highlights the global need for a generally accepted set of standards for sustainability and IR practices.
A method for measuring women climate vulnerability: a case study in Vietnam’s Mekong Delta
Authors: N.M. Quang 
Published: February 2022

Purpose
Across societies, gendered climate response decisions remain top-down and have limited progress because the influenced risk dynamics and their interrelations are not adequately understood. This study aims to address this gap by proposing an interdisciplinary innovative method, called women climate vulnerability (WCV) index, for measuring and comparing a diverse range of risks that threaten to undermine the adaptive capacity and resilience of rural women.

Design/methodology/approach
This paper builds on the literature to identify 12 risk categories across physical, economic and political sectors that affect rural women. These categories and attendant 51 risk indicators form the WCV index. A case study in Ben Tre Province (Vietnam) was used to demonstrate the application of the WCV methodology to rural contexts. The authors combined empirical, survey and secondary data from different sources to form data on the indicators. Structured expert judgment was used to address data gaps. Empirical and expert data were combined using a few weighting steps and a comprehensive coding system was developed to ensure objective evaluation.

Findings
The WCV assessment results reveal a reasonably worrisome picture of women’s vulnerability in Ben Tre as top highest-likelihood and deepest-impact risks predominate in physical and economic risk sectors. Stability, human security and governance categories have lowest scores, demonstrating a fairly politically favourable condition in the province. The medium risk scores captured in land and infrastructure categories reveal promising determinants of the adaptation of women in this rural province. The results demonstrate the usefulness of the WCV index in collecting bottom-up data, evaluating a wide variety of risks that rural women face and pinpointing priority areas that need to be addressed.

Originality/value
The WCV is systematic, customisable and localised. It combines field research and empirical data through structured expert judgment, thus enables researchers to fill data gaps and to do evidence-based assessment about diverse risk vulnerabilities. By doing so, the WCV index gives critical insights into the challenges that rural women face. This enables local governments to better understand cross-sectoral risks, pinpoint priority areas of action and timely channel funding and policy resources to support women where they need it most.
The role of disaster knowledge management in improving housing reconstruction outcomes: with particular reference to Postearthquake reconstruction in Pakistan
Authors: Shaikh Saima , Brown Andre , Enegbuma Wallace Imoudu 
Published: February 2022

Purpose
Rural building practices, especially in developing communities, are often plagued by inadequate local construction knowledge and a limited understanding of the best building practice guidelines. This has contributed significantly to compounding the effect of significant catastrophic events. The purpose of this paper is to examine the potential impact of disaster knowledge management (DKM) on improving housing resilience and makes particular reference to the 2005 earthquake in rural Pakistan.

Design/methodology/approach
Our research uses a comprehensive literature review that involves a qualitative approach to research aimed at understanding the 2005 earthquakes, their impacts, reconstruction challenges and DKM. Conventional published journals, articles, previous case studies and books were included. But importantly, to take in relevant local information, the review also took in published government reports, disaster mitigation policy documents, national and international NGOs publications, conference proceedings and news articles. More than 80 research papers and conference proceedings over 21 years, from 2001 to 2021, were analyzed in eight major online databases. These include Google Scholar, Science Direct, Research Gate, Scopus, Jstor, Springer, Emerald and Semantic Scholar.

Findings
The investigation identified that DKM has an important role to play in capacity building and technical knowledge transmission relating to seismic guidelines aimed at improving housing resilience. Consequently, a theoretical framework was developed, focused primarily on the post-2005 rural reconstruction mechanism and the identification of key challenges to disseminating seismic guidelines effectively in relation to rural construction practices.

Originality/value
This paper makes an original contribution by developing a DKM framework via the identification of key challenges that need to be addressed, in relation to rural construction practices, generally, but particularly in the Pakistan context.
Green corporate reputation and innovation: the role of non-supply chain learning and green supply chain knowledge
Authors: Agyabeng-Mensah Yaw , Afum Ebenezer , Baah Charles 
Published: February 2022

Purpose The growing relevance of environmental sustainability calls for identification of factors that contribute to green innovation and build green corporate reputation. Drawing on the resource-based view theory, this study aims to explore the influence of green logistics knowledge, green customer knowledge, green supplier knowledge, green competitor knowledge, non-supply chain learning on green innovation and green corporate reputation.Design/methodology/approach This study adopts the quantitative research method where questionnaire is used to gather data from managers of the sampled 208 small and medium enterprises (SMEs). The structural equation modelling is used to analyse the survey data and test the proposed hypotheses.Findings The findings reveal that non-supply chain learning, green customer knowledge and green competitor knowledge have both direct and indirect impact on green innovation and green corporate reputation. However, green supplier knowledge and green logistics knowledge directly impact green innovation but indirectly impact green corporate reputation through green innovation.Originality/value Despite the growing literature exploring the relationship between learning, innovation and reputation, their literature in emerging economies remains underdeveloped. This study provides empirical evidence to confirm the role of non-supply chain learning and green supply chain knowledge in building green corporate reputation and developing green innovation of SMEs in an emerging economy.
COVID-19, stock prices, exchange rates and sovereign bonds: a wavelet-based analysis for Brazil and India
Authors: Yilanci Veli , Pata Ugur Korkut 
Published: February 2022

PurposeThis study aims to investigate the impact of the rise in coronavirus disease 2019 (COVID-19) cases on stock prices, exchange rates and sovereign bond yields in both Brazil and India.Design/methodology/approachThe authors employ the wavelet transform coherence (WTC) and continuous wavelet transform (CWT) techniques on daily data from March 17, 2020 to May 8, 2021.FindingsThe findings show that COVID-19 has no impact on exchange rates but slightly increases sovereign bond yields from 2021 onwards. In contrast, the effect of COVID-19 on stock prices is quite high in both countries. There is a considerable consistency between COVID-19 cases and stock prices across different time–frequency dimensions. The rise in COVID-19 cases has an increasing effect on stock prices in Brazil and India, especially in the high-frequency ranges.Originality/valueAs far as the authors know, no prior study has simultaneously analyzed the effects of the COVID-19 pandemic on exchange rates, stock prices and sovereign bonds in Brazil and India.
Exploring intergenerational differences in technology-oriented ethical behavior
Authors: Verma Shivangi , Garg Naval 
Published: February 2022

PurposeThe proliferation of information technology (IT) and IT-enabled devices has brought various challenges for modern organizations. These challenges are aggravated by the fact that the employees of different generations have a varying degree of expertise and ethical orientation regarding technology. This study has two primary objectives to have an in-depth understanding of technology-related ethical behavior of a diverse workforce. First, it aims to develop a valid and reliable scale to measure technology-oriented ethical behavior. Second, it investigates variations in technology-oriented ethical behavior among Generation X (pre-millennial), Generation Y (millennial) and Generation Z (post-millennial) using the scale.Design/methodology/approachThe study is conducted in two steps. The first step, a techno-ethical scale, is developed with the help of the six steps of scale development proposed by Churchill (1979). These steps include exploratory factor analysis (EFA), confirmatory factor analysis (CFA), reliability analysis (composite reliability) and validity analysis (convergent and divergent validity). In the second step, intergenerational variation in different factors of technology-oriented ethical behavior among generation X, Y and Z employees is explored with the help of ANOVA and mean plots.FindingsThe study suggests a four-dimensional techno-ethical scale comprising fourteen statements. These four dimensions of the scale are the invasion of the right of privacy, defamation, self-enrichment and loafing during office hours. The scale is reported to have adequate reliability and validity estimates. Results also recommend statistically significant variations in all four dimensions of technology-oriented ethical behavior among pre-millennial, millennial and post-millennial. Also, except for self-enrichment, the mean values progressively increase from pre-millennial to post-millennial. Even for self-enrichment, the mean value is highest for post-millennial.Originality/valueThis study is one of the pioneer studies that explore ethical orientation towards technology usage of three generations of employees.
Cylindrical conformal wideband antenna with enhancement of gain using integrated parasitic triangular shaped elements for WiMAX application
Authors: Sahoo Ratikanta 
Published: February 2022

Purpose
This paper aims to propose a cylindrical conformal wideband antenna with increased directive behaviour using integrated parasitic triangular-shaped elements for WiMAX application.

Design/methodology/approach
The proposed antenna is a wideband directional cylindrical conformal antenna consisting of three fork-shaped dipole elements incorporated with parasitic triangular-shaped reflecting components increases the gain of reference conformal antenna. The novel parasitic elements with triangular shapes are designed on the radiating patch as well as the ground plane side. The parasitic triangular elements enable the antenna to enhance the gain along the end-fire direction.

Findings
The proposed antenna has a 20.2% impedance bandwidth ranging from 3.1 to 3.8 GHz. The half power beam-width (HPBW) of the reference antenna in the H-plane is 122.9° and falls to 99.1° after integrating with parasitic elements at 3.3 GHz, whereas it falls from 56.7° to 54.7° in the E-plane. However, at 3.5 GHz, the reference antenna’s HPBW is at 116.8°, which decreases to 92.4° in the H-plane, whereas it reduces from 57.9 to 53.4° in the E-plane. The proposed antenna has a lower HPBW than reference antennas and achieved a gain enhancement of 1.2 dBi, indicating that the pattern becomes more directed.

Originality/value
In the proposed work, the directive behaviour of cylindrical conformal antenna structure with a 30 mm radius of curvature is improved using parasitic reflective elements. The fabricated antennas’ experimental findings are an excellent contender for wireless point-to-point WiMAX applications because it features a wideband, directional properties, and strong gain over the whole operational frequency range of 3.1–3.8 GHz.