bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arylcoumarin perturbs SARS-CoV-2 pathogenesis by targeting the S-protein/ACE2 interaction
Authors: Singh Ruhar , Kumar Abhijeet , Rane Jitendra Subhash , Khan Rajni , Tripathi Garima , Ajay Amrendra K. , Prakash Amresh , Ray Shashikant 
Published: October 2022

AbstractThe vaccination drive against COVID-19 worldwide was quite successful. However, the second wave of infections was even more disastrous. There was a rapid increase in reinfections and human deaths due to the appearance of new SARS-CoV-2 variants. The viral genome mutations in the variants were acquired while passing through different human hosts that could escape antibodies in convalescent or vaccinated individuals. The treatment was based on oxygen supplements and supportive protocols due to the lack of a specific drug. In this study, we identified three lead inhibitors of arylated coumarin derivatives 4,6,8-tri(naphthalen-2-yl)-2H-chromen-2-one (NF1), 8-(4-hydroxyphenyl)-4,6-di(naphthalen-2-yl)-2H-chromen-2-one (NF12) and 8-(4-hydroxyphenyl)-3,6-di(naphthalen-2-yl)-2H-chromen-2-one (NF-13) that showed higher binding affinity towards the junction of SARS-CoV-2 spike glycoprotein (S-protein) and human angiotensin-converting enzyme 2 (ACE2) receptor. Using molecular docking analysis, we identified the putative binding sites of these potent inhibitors. Notably, molecular dynamics (MD) simulation and MM-PBSA studies confirmed that these inhibitors have the potential ability to bind Spike-protein/ACE2 protein complex with minimal energy. Further, the two major concerns are an adaptive mutation of spike proteins- N501Y and D614G which displayed strong affinity towards NF-13 in docking analysis. Additionally, in vitro and in vivo studies are required to confirm the above findings and develop the inhibitors as potential drugs against SARS-CoV-2.
Gender stereotypes about intellectual ability in Japanese children
Authors: Okanda Mako , Meng Xianwei , Kanakogi Yasuhiro , Uragami Moe , Yamamoto Hiroki , Moriguchi Yusuke 
Published: October 2022

AbstractJapan has a large gender gap; thus, this study examined whether Japanese 4- to 7-year-old children exhibit a “brilliance = males” stereotype and whether parental attitudes toward gender roles were related to children’s stereotypes. We also explored whether the children exhibited such stereotypes in response to various stimuli. We showed children photos (Study 1) and stick figures (Study 2) of men, women, boys, and girls, asking them to attribute traits (smart or nice) to each. Study 1 revealed overwhelming in-group positivity in girls, whereas the results for boys were rather mixed. In Study 2, girls generally attributed nice to their own gender compared to boys. However, “brilliance = males” stereotypical responses were observed from 7 years of age, when boys began to be more likely to attribute smartness to their own gender compared to girls. The new data in Study 3 replicated results of Study 1 and parts of the results of Study 2. Moreover, merging the Study 3 data with that of Studies 1 and 2 confirmed their findings. Furthermore, it replicated the “brilliance = males” stereotype among 7-year-olds in the stick figure task. Parental attitudes toward gender roles were unrelated to children’s gender stereotypes. The results indicated that Japanese children may acquire “brilliance = males” stereotypes later than American children (6-years-old). Furthermore, the results were clearer when children were presented with stick figure stimuli.
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines
Authors: Mendes-Frias Ana , Gallo Valentina , Iacobelli Valentina , Gentile Roberta , Antonini Giovanni , Silvestre Ricardo , Iacobelli Stefano 
Published: October 2022

AbstractCOVID-19 is the global pandemic that affected our population in the past 2 years. Considerable research has been done to better understand the pathophysiology of this disease and to identify new therapeutic targets, especially for severe cases. Galectin-3 (Gal-3) is a receptor present at the surface of different cell types, namely epithelial and inflammatory cells, which has been described as a severity marker in COVID-19. The activation of Gal-3 through its binding protein (Gal-3BP) is directly linked to the production of pro-inflammatory cytokines that contribute for the cytokine storm (CS) observed in severe COVID-19 patients. Here, we show that D2, a recombinant fragment of the lectin-binding region of Gal-3BP was able to stimulate the expression of IL-6 in colon and lung epithelial cell lines in β-galactoside dependent manner. We further show that D2-induced IL-6 augmentation was reduced by the anti-Gal-3BP monoclonal antibody 1959. Our data confirm and extend prior findings of Gal-3BP mediated IL-6 induction, enlightening the potential of its antibody-mediated s blockage for the prevention and treatment of CS and severe disease in COVID-19 patients.
Design of a novel integrated microfluidic chip for continuous separation of circulating tumor cells from peripheral blood cells
Authors: Bakhshi Maliha Saleem , Rizwan Mohsin , Khan Ghulam Jilany , Duan Hong , Zhai Kefeng 
Published: October 2022

AbstractCancer is one of the foremost causes of death globally. Late-stage presentation, inaccessible diagnosis, and treatment are common challenges in developed countries. Detection, enumeration of Circulating Tumor Cells (CTC) as early as possible can reportedly lead to more effective treatment. The isolation of CTC at an early stage is challenging due to the low probability of its presence in peripheral blood. In this study, we propose a novel two-stage, label-free, rapid, and continuous CTC separation device based on hydrodynamic inertial focusing and dielectrophoretic separation. The dominance and differential of wall-induced inertial lift force and Dean drag force inside a curved microfluidic channel results in size-based separation of Red Blood Cells (RBC) and platelets (size between 2–4 µm) from CTC and leukocytes (9–12.2 µm). A numerical model was used to investigate the mechanism of hydrodynamic inertial focusing in a curvilinear microchannel. Simulations were done with the RBCs, platelets, CTCs, and leukocytes (four major subtypes) to select the optimized value of the parameters in the proposed design. In first stage, the focusing behavior of microscale cells was studied to sort leukocytes and CTCs from RBCs, and platelets while viable CTCs were separated from leukocytes based on their inherent electrical properties using dielectrophoresis in the second stage. The proposed design of the device was evaluated for CTC separation efficiency using numerical simulations. This study considered the influence of critical factors like aspect ratio, dielectrophoretic force, channel size, flow rate, separation efficiency, and shape on cell separation. Results show that the proposed device yields viable CTC with 99.5% isolation efficiency with a throughput of 12.2 ml/h.
Hydrogen generation of single alloy Pd/Pt quantum dots over Co3O4 nanoparticles via the hydrolysis of sodium borohydride at room temperature
Authors: Farrag Mostafa , Ali Gomaa A. M. 
Published: October 2022

AbstractTo satisfy global energy demands and decrease the level of atmospheric greenhouse gases, alternative clean energy sources are required. Hydrogen is one of the most promising clean energy sources due to its high chemical energy density and near-zero greenhouse gas emissions. A single alloyed phase of Pd/Pt nanoclusters as quantum dots (QDs) was prepared and loaded over Co3O4 nanoparticles with a low loading percentage (1 wt.%) for hydrogen generation from the hydrolysis of NaBH4 at room temperature. L-glutathione (SG) was used as a capping ligand. It was found that the single alloy catalyst (Pd0.5–Pt0.5)n(SG)m/Co3O4 caused a significant enhancement in hydrogen generation in comparison to the monometallic clusters (Pdn(SG)m and Ptn(SG)m). Moreover, the Pd/Pt alloy showed a positive synergistic effect compared to the physical mixture of Pd and Pt clusters (1:1) over Co3O4. The QDs alloy and monometallic Pd and Pt clusters exhibited well-dispersed particle size in ~ 1 nm. The (Pd0.5–Pt0.5)n(SG)m)/Co3O4 catalyst offers a high hydrogen generation rate (HGR) of 8333 mL min− 1 g− 1 at room temperature. The synergistic effect of Pd and Pt atoms in the nanoclusters alloy is the key point beyond this high activity, plus the prepared clusters' unique atomic packing structure and electronic properties. The effect of the NaBH4 concentration, catalyst amount, and reaction temperature (25–60 °C) were investigated, where HGR reaches 50 L min− 1 g− 1 at 60 °C under the same reaction conditions. The prepared catalysts were analyzed by UV–Vis, TGA, HR-TEM, XRD, and N2 adsorption/desorption techniques. The charge state of the Pd and Pt in monometallic and alloy nanoclusters is zero, as confirmed by X-ray photoelectron spectroscopy analysis. The catalysts showed high recyclability efficiency for at least five cycles due to the high leaching resistance of the alloy nanoclusters within the Co3O4 host. The prepared catalysts are highly efficient for energy-based applications.
The influence of self-reported history of mild traumatic brain injury on cognitive performance
Authors: Fox Amaya J. , Filmer Hannah L. , Dux Paul E. 
Published: October 2022

AbstractThe long-term cognitive consequences of mild traumatic brain injury (mTBI) are poorly understood. Studies investigating cognitive performance in the chronic stage of injury in both hospital-based and population-based samples have revealed inconsistent findings. Importantly, population-based mTBI samples remain under-studied in the literature. This study investigated cognitive performance among individuals with a history of self-reported mTBI using a battery of cognitively demanding behavioural tasks. Importantly, more than half of the mTBI participants had experienced multiple mild head injuries. Compared to control participants (n = 49), participants with a history of mTBI (n = 30) did not demonstrate deficits in working memory, multitasking ability, cognitive flexibility, visuospatial ability, response inhibition, information processing speed or social cognition. There was moderate evidence that the mTBI group performed better than control participants on the visual working memory measure. Overall, these findings suggest that even multiple instances of mTBI do not necessarily lead to long-term cognitive impairment at the group level. Thus, we provide important evidence of the impact of chronic mTBI across a number of cognitive processes in a population-based sample. Further studies are necessary to determine the impact that individual differences in injury-related variables have on cognitive performance in the chronic stage of injury.
Closed-loop stimulation of lateral cervical spinal cord in upper-limb amputees to enable sensory discrimination: a case study
Authors: Nanivadekar Ameya C. , Chandrasekaran Santosh , Helm Eric R. , Boninger Michael L. , Collinger Jennifer L. , Gaunt Robert A. , Fisher Lee E. 
Published: October 2022

AbstractModern myoelectric prosthetic hands have multiple independently controllable degrees of freedom, but require constant visual attention to use effectively. Somatosensory feedback provides information not available through vision alone and is essential for fine motor control of our limbs. Similarly, stimulation of the nervous system can potentially provide artificial somatosensory feedback to reduce the reliance on visual cues to efficiently operate prosthetic devices. We have shown previously that epidural stimulation of the lateral cervical spinal cord can evoke tactile sensations perceived as emanating from the missing arm and hand in people with upper-limb amputation. In this case study, two subjects with upper-limb amputation used this somatotopically-matched tactile feedback to discriminate object size and compliance while controlling a prosthetic hand. With less than 30 min of practice each day, both subjects were able to use artificial somatosensory feedback to perform a subset of the discrimination tasks at a success level well above chance. Subject 1 was consistently more adept at determining object size (74% accuracy; chance: 33%) while Subject 2 achieved a higher accuracy level in determining object compliance (60% accuracy; chance 33%). In each subject, discrimination of the other object property was only slightly above or at chance level suggesting that the task design and stimulation encoding scheme are important determinants of which object property could be reliably identified. Our observations suggest that changes in the intensity of artificial somatosensory feedback provided via spinal cord stimulation can be readily used to infer information about object properties with minimal training.
The spatial–temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV‑A71 vaccination in Kunming, China, 2017–2020
Authors: Wang Meifen , Chen Tao , Peng Junchao , Luo Yunjiao , Du Lijiang , Lu Zhiying , He Jianzhu , Liu Chunli , Gan Quan , Ma Wei , Cun Zhikuan , Zheng Qiongmei , Chen Weiying , Chen Yonglin , Han Mei , Liu Guojun , Li Jiwei 
Published: October 2022

AbstractAfter vaccination with enterovirus 71 (EV-A71), the prevalence of hand-foot-and-mouth disease (HFMD) remained high, and the spatial–temporal distribution of enteroviruses changed. Therefore, it is essential to define the temporal features, spatial distributions, and epidemiological and etiological characteristics of HFMD in Kunming. Between 2017 and 2020, a total of 36,540 children were diagnosed with HFMD in Kunming, including 32,754 children with enterovirus-positive clinical samples. Demographic, geographical, epidemiological and etiological data of the cases were acquired and analyzed. Other enteroviruses replaced EV-A71, and the incidence of EV-A71 decreased dramatically, whereas coxsackievirus A6 (CV-A6) and coxsackievirus A16 (CV-A16) had substantial outbreaks in 2018 and 2019, respectively. The major and minor peaks all extended for 2–4 months compared to before vaccination with the EV-A71 vaccine. From 2019 to 2020, CV-A6, as the predominant serotype, showed only a single peak. Although a high incidence of HFMD was observed in Guandu, Chenggong and Xishan, the annual incidence of different enterovirus serotypes was different in different regions. In 2017, other enteroviruses were most prevalent in Shilin. In 2018, CV-A16 and CV-A6 were most prevalent in Luquan and Shilin, respectively. In 2019, CV-A16 was most prevalent in Jinning. In 2020, CV-A6 and coxsackievirus A10 (CV-A10) were most prevalent in Luquan and Shilin, respectively. Meanwhile, the epidemic cycle of CV-A6 and CV-A16 was only 1 year, and CV-A10 and other enteroviruses were potential risk pathogens. The spatial and temporal distribution of HFMD varies at different scales, and the incidence of HFMD associated with different pathogens has obvious regional differences and seasonal trends. Therefore, research on multivalent combined vaccines is urgently needed, and proper preventive and protective measures could effectively control the incidence of HFMD-like diseases.
Frustrations of supported catalytic clusters under operando conditions predicted by a simple lattice model
Authors: Korobov Alexander 
Published: October 2022

AbstractThe energy landscape with a number of close minima separated by low barriers is a well-known issue in computational heterogeneous catalysis. In the framework of the emerging out-of-equilibrium material science, the navigation through such involved landscapes is associated with the functionality of materials. Current advancements in the cluster catalysis has brought and continues to bring essential nuances to the topic. One of them is the possibility of frustration of the catalytic centre under operando conditions. However, this conjecture is difficult to check either experimentally or theoretically. As a step in this direction, as-simple-as-possible lattice model is used to estimate how the supposed frustrations may couple with the elementary reaction and manifest themselves at the macroscopic scale.
Choroidal hemodynamics in central serous chorioretinopathy after half-dose photodynamic therapy and the effects of smoking
Authors: Horiguchi Etsuyo , Takeuchi Jun , Tomita Ryo , Asai Keiko , Nakano Yuyako , Ota Hikaru , Taki Yosuke , Ito Yasuki , Terasaki Hiroko , Nishiguchi Koji M. , Kataoka Keiko 
Published: October 2022

AbstractThis retrospective study aimed to evaluate choroidal hemodynamics after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) and the effects of smoking using laser speckle flowgraphy. This study included 29 eyes of 29 patients treated with half-dose PDT for CSC, who were followed-up for at least 6 months. The mean blur rate (MBR) in the PDT irradiation area (whole area), the pachyvessel (PV) area, non-PV (NPV) area, and filling delay (FD) area were assessed at baseline and 1, 3, and 6 months post-PDT, respectively. The MBR was also assessed by smoking status. The MBR significantly decreased from baseline in the whole, PV, NPV, and FD areas at all time points (P < 0.001). Of the 29 patients, 6 were never smokers, 13 were past smokers, and 10 were current smokers. At baseline, no significant difference was found in the MBR in the whole, PV, NPV, and FD areas among never, past, and current smokers. The MBR changes showed a significantly smaller decrease in current smokers than in never smokers in the whole (P = 0.021), PV (P = 0.009), and NPV (P = 0.034) areas, but not in the FD area (P = 0.172). Half-dose PDT for CSC reduced choroidal blood flow in the PDT-irradiated area, which was blunted by current smoking status.
Preparation and application of nanostructured carbon from oil fly ash for growth promotion and improvement of agricultural crops with different doses
Authors: Alluqmani Saleh M. , Alabdallah Nadiyah M. 
Published: October 2022

AbstractApplication of carbon nanomaterials (CNMs) in agricultural production has piqued the interest of researchers. However, despite the enormous importance of CNMs in plant development, little is known about the effects of carbon nanoparticle (CNP) doses on plant physiological responses. Therefore, the aim of the current study was to check the effects of nanostructured carbon derived from oil fly ash (COFA), which was derived for the first time from high-energy ball-milling followed by a sonication process, on Phaseolus vulgaris L. and Cicer arietinum L. plants. We evaluated the plant physiological and biochemical parameters of the COFA-treated seedlings. Two different doses (4 mg L−1 and 8 mg L−1) of COFA and a control were studied. The results indicated that the germination rate (%), shoot length, root length, pod length, leaf area, fresh weight and dry weight were increased with the addition of COFA. Likewise, COFA increased the contents of chlorophyll pigments (Chla, Chlb, carotenoids), proteins, and carbohydrates in both species compared to the control. Finally, these findings showed that a COFA treatment at 4 mg L−1 after ball milled-sonication in water (BMW4) constituted the best dose for growth and physiology. Our findings reveal that the novel strategy of COFA engineering led to a boost in the growth of Phaseolus vulgaris and Cicer arietinum. Our results have high potential for agricultural research and provide an impact on food security.
Emission line star catalogues post-Gaia DR3
Authors: Shridharan B. , Mathew B. , Bhattacharyya S. , Robin T. , Arun R. , Kartha S. S. , Manoj P. , Nidhi S. , Maheshwar G. , Paul K. T. , Narang M. , Himanshu T. 
Published: October 2022

Aims.Gaia Data Release 3 (DR3) and further releases have the potential to identify and categorise new emission-line stars in the Galaxy. We perform a comprehensive validation of astrophysical parameters from Gaia DR3 with the spectroscopically estimated emission-line star parameters from the LAMOST OBA emission catalogue.
Method. We compare different astrophysical parameters provided by Gaia DR3 with those estimated using LAMOST spectra. By using a larger sample of emission-line stars, we performed a global polynomial and piece-wise linear fit to update the empirical relation to convert the Gaia DR3 pseudo-equivalent width to the observed equivalent width, after removing the weak emitters from the analysis.
Results. We find that the emission-line source classifications given by DR3 is in reasonable agreement with the classification from the LAMOST OBA emission catalogue. The astrophysical parameters estimated by the esphs module from Gaia DR3 provides a better estimate when compared to gspphot and gspspec. A second degree polynomial relation is provided along with piece-wise linear fit parameters for the equivalent width conversion. We notice that the LAMOST stars with weak Hα emission are not identified to be in emission from BP/RP spectra. This suggests that emission-line sources identified by Gaia DR3 are incomplete. In addition, Gaia DR3 provides valuable information about the binary and variable nature of a sample of emission-line stars.
Gibt es nachweisbare Effekte durch das geänderte Organspendegesetz?
Authors: Heise Michael , Bechstein Wolf Otto 
Published: October 2022

ZusammenfassungDie Transplantation ist eine effiziente und standardisierte Therapie in der Behandlung des irreversiblen Organversagens. Damit möglichst viele geeignete Patienten in Deutschland von
dieser Therapieoption profitieren, muss der im internationalen Vergleich niedrige Organmangel in Deutschland als ein zentrales Problem der Transplantationsmedizin behoben werden.
Die Ursachenanalyse des Organmangels führte zu Änderungen im Gesetz über die Spende, Entnahme und Übertragung von Organen und Gewebe (Transplantationsgesetz – TPG), welche
konsekutiv Prozessanpassungen und Strukturverbesserungen der Rahmenbedingungen der Organspende in Deutschland zur Folge hatten und zu einer Steigerung der Organspenderzahlen
beitragen sollten. Die aktuellen Organspenderzahlen zeigen, dass die angestoßenen strukturellen Maßnahmen kurzfristig nicht zu einer Trendwende führten. Das geänderte
Transplantationsgesetz wird aber nur dann langfristige Effekte erzielen, wenn die gemeinschaftliche Aufgabe zur Organspende in der deutschen Gesellschaft breiten Konsens findet.
Ein rationaler öffentlicher Diskurs in Deutschland über die Optionen zur Behebung des Organspendemangels – dazu gehören auch die Widerspruchslösung und die Organspende nach Herz-
und Kreislauftod (DCD) – ist dringend geboten.