bluuebunny/crossref_metadata_2025_split huggingface dataset:
Typhoon Effects on the Vertical Chlorophyll Distribution on the Northern Shelf of the South China Sea
Authors: Fang Weiwei , Geng Bingxu , Xiu Peng 
Published: December 2022

AbstractTyphoon Merbok passed through the northern South China Sea and landed near the Pearl River Estuary in June 2017. Field observations showed that the chlorophyll‐a (Chla) concentration in the bottom/subsurface chlorophyll maximum (BCM/SCM) layer decreased in both nearshore and offshore regions after Merbok. In addition, the BCM/SCM layer became shallower in the nearshore region and deeper in the offshore region after Merbok. A coupled physical‐biogeochemical model was applied to investigate the driving mechanism for this Chla change. During the typhoon, the spatial movement of plume water was responsible for the surface Chla change in the nearshore region, and vertical mixing increased Chla in the upper layer and decreased it in the SCM layer in the offshore region. Shortly after the typhoon, surface Chla increased and bottom Chla decreased in the nearshore region, which was associated with strengthened bottom flow and vertical mixing. When the typhoon‐induced mixing decreased, upwelling tended to shoal the BCM layer in the nearshore region, and phytoplankton production increased Chla in the BCM layer. In the offshore region, vertical mixing was the dominant mechanism for Chla redistribution during the typhoon, which decreased Chla in the SCM layer and resulted in a deeper SCM layer. A few days after the typhoon, phytoplankton production also contributed to the Chla change particularly in the subsurface layer, which was stronger in the nearshore region than that in the offshore region. These findings may contribute to the understanding of phytoplankton dynamics in response to typhoons in coastal areas.
Long term follow-up after haematopoietic stem cell transplantation for mucopolysaccharidosis type I-H: a retrospective study of 51 patients
Authors: Gardin Antoine , Castelle Martin , Pichard Samia , Cano Aline , Chabrol Brigitte , Piarroux Julie , Roubertie Agathe , Nadjar Yann , Guemann Anne-Sophie , Tardieu Marine , Lacombe Didier , Robert Matthieu P. , Caillaud Catherine , Froissart Roseline , Leboeuf Virginie , Barbier Valérie , Bouchereau Juliette , Schiff Manuel , Fauroux Brigitte , Thierry Briac , Luscan Romain , James Syril , de Saint-Denis Timothée , Pannier Stéphanie , Gitiaux Cyril , Vergnaud Estelle , Boddaert Nathalie , Lascourreges Claire , Lemoine Michel , Bonnet Damien , Blanche Stéphane , Dalle Jean-Hugues , Neven Bénédicte , de Lonlay Pascale , Brassier Anaïs 
Published: December 2022

AbstractMucopolysaccharidosis type I-H (MPS I-H) is a rare lysosomal storage disorder caused by α-L-Iduronidase deficiency. Early haematopoietic stem cell transplantation (HSCT) is the sole available therapeutic option to preserve neurocognitive functions. We report long-term follow-up (median 9 years, interquartile range 8–16.5) for 51 MPS I-H patients who underwent HSCT between 1986 and 2018 in France. 4 patients died from complications of HSCT and one from disease progression. Complete chimerism and normal α-L-Iduronidase activity were obtained in 84% and 71% of patients respectively. No difference of outcomes was observed between bone marrow and cord blood stem cell sources. All patients acquired independent walking and 91% and 78% acquired intelligible language or reading and writing. Intelligence Quotient evaluation (n = 23) showed that 69% had IQ ≥ 70 at last follow-up. 58% of patients had normal or remedial schooling and 62% of the 13 adults had good socio-professional insertion. Skeletal dysplasia as well as vision and hearing impairments progressed despite HSCT, with significant disability. These results provide a long-term assessment of HSCT efficacy in MPS I-H and could be useful in the evaluation of novel promising treatments such as gene therapy.
Adhesive free, conformable and washable carbon nanotube fabric electrodes for biosensing
Authors: Hossain Md. Milon , Li Braden M. , Sennik Busra , Jur Jesse S. , Bradford Philip D. 
Published: December 2022

AbstractSkin-mounted wearable electronics are attractive for continuous health monitoring and human-machine interfacing. The commonly used pre-gelled rigid and bulky electrodes cause discomfort and are unsuitable for continuous long-term monitoring applications. Here, we design carbon nanotubes (CNTs)-based electrodes that can be fabricated using different textile manufacturing processes. We propose woven and braided electrode design using CNTs wrapped textile yarns which are highly conformable to skin and measure a high-fidelity electrocardiography (ECG) signal. The skin-electrode impedance analysis revealed size-dependent behavior. To demonstrate outstanding wearability, we designed a seamless knit electrode that can be worn as a bracelet. The designed CNT-based dry electrodes demonstrated record high signal-to-noise ratios and were very stable against motion artifacts. The durability test of the electrodes exhibited robustness to laundering and practicality for reusable and sustainable applications.
Physical imaging parameter variation drives domain shift
Authors: Kilim Oz , Olar Alex , Joó Tamás , Palicz Tamás , Pollner Péter , Csabai István 
Published: December 2022

AbstractStatistical learning algorithms strongly rely on an oversimplified assumption for optimal performance, that is, source (training) and target (testing) data are independent and identically distributed. Variation in human tissue, physician labeling and physical imaging parameters (PIPs) in the generative process, yield medical image datasets with statistics that render this central assumption false. When deploying models, new examples are often out of distribution with respect to training data, thus, training robust dependable and predictive models is still a challenge in medical imaging with significant accuracy drops common for deployed models. This statistical variation between training and testing data is referred to as domain shift (DS).To the best of our knowledge we provide the first empirical evidence that variation in PIPs between test and train medical image datasets is a significant driver of DS and model generalization error is correlated with this variance. We show significant covariate shift occurs due to a selection bias in sampling from a small area of PIP space for both inter and intra-hospital regimes. In order to show this, we control for population shift, prevalence shift, data selection biases and annotation biases to investigate the sole effect of the physical generation process on model generalization for a proxy task of age group estimation on a combined 44 k image mammogram dataset collected from five hospitals.We hypothesize that training data should be sampled evenly from PIP space to produce the most robust models and hope this study provides motivation to retain medical image generation metadata that is almost always discarded or redacted in open source datasets. This metadata measured with standard international units can provide a universal regularizing anchor between distributions generated across the world for all current and future imaging modalities.
Social affiliation is sufficient to provoke the partner-advantage
Authors: Tseng Chia-huei , Jingling Li , Cheng Miao 
Published: December 2022

AbstractThe partner-advantage is a type of identity-priority processing that we afford to a person with whom we perform a task together 1. The partner-advantage has been revealed by shortened reaction time (RT) and enhanced accuracy when participants learned to match a shape with an associated name. It is distinguished from other long-lasting and robust identity advantages (e.g., self-advantage and friend-advantage) by its instantaneous build-up and quick reduction; however, its characteristics and enabling factors remain unknown. The present study addresses these questions. In Experiment 1, we replicated the partner-advantage in a solo shape-name matching task (i.e., without a social component) in which other identity biases are usually reported. In Experiment 2, an absent partner (who did not appear physically) was sufficient to induce beneficial partner-related processing, with a temporary partner enjoying a benefit similar to that of significant others. In Experiment 3, an identity low in socially affiliated significance (e.g., another participant in the same experiment) did not automatically enjoy a priority bias. Taken together, our results suggest that the bias toward partners, similar to other known identity biases, does not require physical presence to build and maintain a referential advantage. The partner-advantage does not automatically extend to other social affiliations, and a joint task is not a pre-requisite to produce the bias. Our study offers new insights on identity-referential processing and its underlying mechanisms.
Photoreceptor density in relation to axial length and retinal location in human eyes
Authors: Panda-Jonas Songhomitra , Jonas Jost B. , Jonas Rahul A. 
Published: December 2022

AbstractThe purpose of the study was to examine the density of retinal photoreceptors and retinal pigment epithelium (RPE) cells in relation to myopic axial elongation in human eyes. Using light microscopy, we assessed the density of photoreceptors and RPE cells at the ora serrata, equator, and midperiphery (equator/posterior pole midpoint), and the RPE cell density additionally at the posterior pole, in enucleated human globes. The study included 78 eyes (mean age: 59.2 ± 15.6 years; range: 32–85 years) with a mean axial length of 27.3 ± 3.6 mm (range: 21.5–37.0 mm). Close to the ora serrata, at the equator and midperiphery, photoreceptor and RPE cell density was 246 ± 183, 605 ± 299 and 1089 ± 441 photoreceptors/mm and 56.1 ± 13.7, 45.2 ± 15.1, and 48.8 ± 15.6 RPE cells/mm, respectively. Densities of both cell types in all three regions were positively correlated with each other (all P < 0.001) and decreased with longer axial length (all P < 0.001) and longer distance between the ora serrata and the posterior pole (all P < 0.001), most marked at the midperiphery and least marked close to the ora serrata. The PRE cell density at the posterior pole was not significantly (P = 0.35) related to axial length. The photoreceptor density at the ora serrata (beta:− 0.33) and equator (beta: − 0.27) and RPE cell density at the ora serrata (beta: − 0.27) decreased additionally with the presence of glaucoma. The findings suggest that the axial elongation-related decrease in photoreceptor and RPE cell density is most marked at the midperiphery, followed by the equator and finally the ora serrata region. It suggests that the axial elongation-related enlargement of the eye wall predominantly takes place in the retro-equatorial region, followed by the equatorial region.
Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease
Authors: Yagishita Mizuki , Tsuboi Hiroto , Kuroda Yuki , Sawabe Tomonori , Kawashima Akira , Kawashima Fumina , Uematsu Nana , Sato Ryota , Nishiyama Taihei , Terasaki Mayu , Toko Hirofumi , Honda Fumika , Ohyama Ayako , Abe Saori , Kitada Ayako , Miki Haruka , Hagiwara Shinya , Kondo Yuya , Sumida Takayuki , Matsumoto Isao 
Published: December 2022

AbstractRecent studies have suggested that the clinical features of elderly-onset adult-onset Still’s disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clinical features and cytokine profiles of elderly-onset AOSD, we examined patients with AOSD who developed the disease between January 2006 and September 2021. We divided the patients into the young and middle-aged-onset group (aged < 65 years) and the elderly-onset group (aged ≥ 65 years) and compared the groups in terms of patient characteristics, clinical symptoms, laboratory findings including serum interleukin (IL)-6 and IL-18, treatment, and prognosis. A total of 48 patients were examined (10 in the elderly-onset group). In the elderly-onset group, atypical rash was significantly more frequent, typical rash and splenomegaly were significantly less frequent, white blood cell count and neutrophil ratio were significantly higher and serum IL-6 levels were significantly lower. Serum IL-6 showed a significantly negative correlation with age at onset. Treatment and relapse were comparable between the 2 groups, whereas infections were significantly more frequent in the elderly-onset group. The clinical features and cytokine profiles of elderly-onset AOSD might differ from those of young and middle-aged-onset AOSD.
Hybridization of surface plasmons and photonic crystal resonators for high-sensitivity and high-resolution sensing applications
Authors: Hajshahvaladi Leila , Kaatuzian Hassan , Moghaddasi Maryam , Danaie Mohammad 
Published: December 2022

AbstractIn this paper, an optical refractive index (RI) sensor based on a hybrid plasmonic-photonic crystal (P-PhC) is designed. In the sensor’s structure, some metallic rods are embedded in a rod-type photonic crystal (PhC) structure. Numerical simulations are performed based on the finite-difference time-domain (FDTD) method. The obtained results illustrate that the localized surface plasmons (LSP) induced by metallic rods can be excited in a PhC lattice to generate a hybrid P-PhC mode. According to the results, the hybrid mode provides unique opportunities. Using metallic rods in the coupling regions between waveguides and the resonant cavity significantly increases the interaction of the optical field and analyte inside the cavity. The simulation results reveal that high sensitivity of 1672 nm/RIU and an excellent figure of merit (FoM) of 2388 RIU−1 are obtained for the proposed hybrid P-PhC sensor. These values are highest compared to the purely plasmonic and or purely PhC sensors reported in the literature. The proposed sensor could simultaneously enhance sensitivity and FoM values. Therefore, the proposed hybrid P-PhC RI sensor is a more fascinating candidate for high-sensitivity and high-resolution sensing applications at optic communication wavelengths.
Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors
Authors: Lee Jessica K. , Sivakumar Smruthy , Schrock Alexa B. , Madison Russell , Fabrizio David , Gjoerup Ole , Ross Jeffrey S. , Frampton Garrett M. , Napalkov Pavel , Montesion Meagan , Schutzman Jennifer L. , Ye Xin , Hegde Priti S. , Nagasaka Misako , Oxnard Geoffrey R. , Sokol Ethan S. , Ou Sai-Hong Ignatius , Shi Zhen 
Published: December 2022

AbstractRecent clinical development of KRAS inhibitors has heightened interest in the genomic landscape of KRAS-altered cancers. We performed a pan-cancer analysis of KRAS-altered samples from 426,706 adult patients with solid or hematologic malignancies using comprehensive genomic profiling; additional analyses included 62,369 liquid biopsy and 7241 pediatric samples. 23% of adult pan-cancer samples had KRAS alterations; 88% were mutations, most commonly G12D/G12V/G12C/G13D/G12R, and prevalence was similar in liquid biopsies. Co-alteration landscapes were largely similar across KRAS mutations but distinct from KRAS wild-type, though differences were observed in some tumor types for tumor mutational burden, PD-L1 expression, microsatellite instability, and other mutational signatures. Prognosis of KRAS-mutant versus other genomic cohorts of lung, pancreatic, and colorectal cancer were assessed using a real-world clinicogenomic database. As specific KRAS inhibitors and combination therapeutic strategies are being developed, genomic profiling to understand co-alterations and other biomarkers that may modulate response to targeted or immunotherapies will be imperative.
Mechanisms of circular RNA degradation
Authors: Ren Longxin , Jiang Qingshan , Mo Liyi , Tan Lijie , Dong Qifei , Meng Lijuan , Yang Nanyang , Li Guoqing 
Published: December 2022

AbstractCircular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs.
Psychosoziale Aspekte im Leben mit autoinflammatorischen Erkrankungen im Kindes- und Jugendalter
Authors: Erbis Gabi 
Published: December 2022

ZUSAMMENFASSUNGBei den autoinflammatorischen Erkrankungen (AID) handelt es sich um seltene, genetische Erkrankungen. So verschieden wie die Krankheitsbilder selbst, so unterschiedlich sind die Auswirkungen auf den Alltag der Patient*innen und ihrer Familien. Durch ihre Unbekanntheit und die unspezifischen Symptome wie Erschöpfung und Schmerzen dauert es häufig sehr lange bis eine Diagnose gestellt werden kann. Fehldiagnosen sind häufig. Oftmals werden psychische Ursachen vermutet. Besonders eingreifend können die Konsequenzen für das soziale Leben der Familien und für die Schullaufbahn der Patient*innen sein. Durch eine multiprofessionelle Versorgung kann die gesamte Lebenssituation der Patient*innen und ihrer Familien berücksichtigt und in die Behandlung einbezogen werden.
2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora
Authors: Chen Shu-Rong , Chen Yih-Fung , Lin Jue-Jun , Ke Tzu-Yi , Lin Yun-Sheng , Cheng Yuan-Bin 
Published: December 2022

AbstractThree new alkaloids, hipporidine A (1), hipporidine B (2), and (−)-lobeline N-oxide (3), were discovered from the whole plant of Hippobroma longiflora
together with five known compounds (4–8). Their 2,6-disubstituted piperidine structures were established based on the HRESIMS, NMR (COSY, HMBC, HSQC, NOESY), and UV
spectroscopic data. Hipporidines A (1) and B (2) possess a rare 1,3-oxazinane moiety. Compound 3 is the N-oxide derivative of (−)-lobeline (6). Moreover,
the absolute configuration of norlobeline (5) was established by single-crystal X-ray diffraction analysis. Three major secondary metabolites (6–8) were evaluated for
their neuroprotective effect against paclitaxel-induced neurotoxicity. Consequently, pretreatment with compound 8 at a concentration of 1.0 µM displayed significant attenuation on
paclitaxel-damaged neurite outgrowth of dorsal root ganglion neurons without interfering with the cytotoxicity of paclitaxel on cervical cancer SiHa cells.
Effekte eines Beweglichkeits- und Krafttrainings auf die
schmerzbedingten Beschwerden bei Brustkrebspatientinnen
Authors: Michels Dominique , Heckel Alexandra , König Stefan 
Published: December 2022

Zusammenfassung
Ziel Ziel dieser Studie war, Wirkungen eines Beweglichkeitstrainings an
FIVE®-Geräten in Kombination mit
gerätegestützten Kraftübungen auf die schmerzbedingten
Beschwerden bei Brustkrebspatientinnen in der Rehabilitation zu analysieren.
Methoden Durchgeführt wurde eine
Prätest-Posttest-Interventionsstudie mit Brustkrebspatientinnen
(n=41), die während ihrer stationären
Anschlussheilbehandlung in einer Rehabilitationsklinik in Bad Waldsee zwischen
Februar und März 2020 in zwei Gruppen randomisiert wurden. Im Rahmen der
medizinischen Trainingstherapie führte die Interventionsgruppe
(n=24) ein Beweglichkeitstraining an den
FIVE®-Geräten in Kombination mit
gerätegestütztem Krafttraining durch, während die
Kontrollgruppe (n=17) ein gerätegestütztes Krafttraining
absolvierte. Vor und nach der dreiwöchigen Intervention (3
Trainingseinheiten/Woche) wurden die Beweglichkeit der Schulter und die
isokinetische Maximalkraft gemessen sowie die schmerzbedingten Beschwerden
anhand einer selbstentwickelten Schmerzskala abgefragt.
Ergebnisse Alle Patientinnen erreichten verbesserte Schmerzwerte mit
Ausnahme der Kategorie 1 (Selbstversorgung/Körperpflege) in der
Interventionsgruppe. Eine Prüfung der statistischen Unterschiede
zwischen den Messzeitpunkten 1 und 2 ergab, dass bei der Kontrollgruppe keine
statistisch signifikanten Verbesserungen bei der Schmerzwahrnehmung beobachtet
werden können; demgegenüber zeigte die Experimentalgruppe
zumindest beim Konstrukt „Arbeitsfähigkeit“ statistisch
signifikante Verbesserungen. Die Berechnung der Effektgrößen r
bzw. η2 machte allerdings auch bei einigen statistisch nicht
signifikanten Veränderungen deutlich, dass mittlere bis große
Effekte hinsichtlich einer geringeren Schmerzwahrnehmung vorlagen.
Schlussfolgerung Sowohl ein kombiniertes Kraft- und Beweglichkeitstraining
an FIVE®-Geräten als auch ein ausschließlich
gerätegestütztes Krafttraining kann bei
Mammakarzinom-Patientinnen in der Phase der Rehabilitation empfohlen werden.
Der Nutzen von Cannabis in der Krebstherapie
Authors: Grotenhermen Franjo 
Published: December 2022

ZusammenfassungCannabis und Cannabinoide können bei der Palliation einer Anzahl von
krebsassoziierten Symptomen hilfreich sein, darunter Appetitlosigkeit mit
Gewichtsverlust, Übelkeit und Erbrechen, Schmerzen,
Schlafstörungen und Depressionen. Einige dieser Indikationen gelten
heute als etabliert. In der Grundlagenforschung wurde darüber hinaus
nachgewiesen, dass eine Anzahl von Cannabinoiden, darunter THC (Dronabinol) und
CBD (Cannabidiol), krebshemmende Eigenschaften besitzen. Es gibt Belege
für eine Anzahl von Wirkmechanismen, darunter die Hemmung der
Tumorzellproliferation, die Auslösung von Apoptosen und Autophagie, die
Hemmung der Tumorinvasion und der Bildung von Metastasen, der Angioneogenese und
der Chemoresistenz. Cannabinoide könnten auch vor einigen
zytostatikabedingten Schäden schützen, darunter vor der
Entwicklung einer peripheren Neuropathie. Allerdings wurden in einzelnen
Untersuchungen auch krebsfördernde Eigenschaften von Cannabinoiden
beobachtet. Die klinische Datenlage ist bisher sehr limitiert. Es gibt
eindrucksvolle Fallberichte über eine erfolgreiche Krebstherapie mit CBD
und THC sowie einige epidemiologische Studien und wenige klinische Daten, die
ein therapeutisches Potenzial von cannabisbasierten Medikamenten
unterstützen.