bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring green innovation through total quality management and corporate social responsibility within SMEs: green theory under the lens
Authors: Azam Tamoor , Songjiang Wang , Jamil Khalid , Naseem Sobia , Mohsin Muhammad 
Published: October 2022

PurposeIn the modern business world, the main focus of the organizations is to improve the quality of the products and minimize the wastage of raw material. Keeping in view the green theory and improve the efficiency of the organization, the focus of the current study is to investigate the relationship between total quality management (TQM) and green innovation (GI), and examine how TQM practices can facilitate firms to achieve GI objectives. Corporate social responsibility (CSR) is also an important factor for organizations, and this study also focuses on the mediating role of CSR between the relationship of TQM and GI.Design/methodology/approachThis is an empirical study. Data were gathered from the top management of 355 SMEs working in Pakistan through a questionnaire survey; the PLS-SEM approach was used to analyse the data.FindingsResults of the study show that TQM has significant impacts on two aspects of GI namely green product innovation and green process innovation. Moreover, results also reveal that CSR partially mediates the relationship between TQM and GI.Research limitations/implicationsThis study is limited to manufacturing SMEs and future research should test this model on non-manufacturing sector too. The findings of the study provide significant roadmap to the management of small and medium-sized manufacturing firms that how they can reduce wastage and improve the product and process innovation in their organizations through TQM and CSR.Originality/valueThis study contributes to bridging research gaps in the literature and advances how TQM, directly and indirectly, help firms improve green innovation via mediating roles of CSR.
Thermal analysis of concrete slabs with insulating materials using ANSYS
Authors: A. Parvathidevi , Ch Naga Satish Kumar 
Published: October 2022

Purpose
This study aims to assess the efficacy of thermal analysis of concrete slabs by including different insulation materials using ANSYS. Regression equations were proposed to predict the thermal conductivity using concrete density. As these simulation and regression analyses are essential tools in designing the thermal insulation concretes with various densities, they sequentially reduce the associated time, effort and cost.

Design/methodology/approach
Two grades of concretes were taken for thermal analysis. They were designed by replacing the natural fine aggregates with thermal insulation aggregates: expanded polystyrene, exfoliated vermiculite and light expanded clay. Density, temperature difference, specific heat capacity, thermal conductivity and time were measured by conducting experiments. This data was used to simulate concrete slabs in ANSYS. Regression analysis was performed to obtain the relation between density and thermal conductivity. Finally, the quality of the predicted regression equations was assessed using root mean square error (RMSE), mean absolute error (MAE), integral absolute error (IAE) and normal efficiency (NE).

Findings
ANSYS analysis on concrete slabs accurately estimates the thermal behavior of concrete, with lesser error value ranges between 0.19 and 7.92%. Further, the developed regression equations proved accurate with lower values of RMSE (0.013 to 0.089), MAE (0.009 to 0.088); IAE (0.216 to 5.828%) and higher values of NE (94.16 to 99.97%).

Originality/value
The thermal analysis accurately simulates the experimental transfer of heat across the concrete slab. Obtained regression equations proved helpful while designing the thermal insulation concrete.
Heat it up to slow it down: Individual energetics reveal how warming reduces stream decomposition
Authors: Jochum Malte 
Published: October 2022

AbstractResearch Highlight: Réveillon, T., Rota, T., Chauvet, É., Lecerf, A., & Sentis, A. (2022). Energetic mismatch induced by warming decreases leaf litter decomposition by aquatic detritivores. Journal of Animal Ecology, https://doi.org/10.1111/1365‐2656.13710. Global change holds complex consequences for Earth's ecosystems, with global warming simultaneously affecting multiple aspects including individual physiology, population dynamics and ecosystem processes. In a recent study on stream decomposition under global warming, Réveillon, et al. (2022) combined individual‐level laboratory assessments of metabolic rates and leaf‐litter ingestion with experimentally parameterized consumer‐resource models, designed to reveal how stream‐detritivore populations respond to combined impacts of warming and declining body size. Their findings of reduced energetic efficiency, weakened detritivore populations and reduced decomposition in warmed streams expand our understanding of how global change mechanistically links changes from the individual to the ecosystem level.
Mothers, milk and mourning: The meanings of breast milk after loss of an infant
Authors: Waldby Catherine , Noble‐Carr Debbie , Carroll Katherine 
Published: October 2022

AbstractBreast milk is a highly valued substance, immunologically and nutritionally, which also signifies maternal care and love for the infant. This intersection of biological and cultural qualities confers breast milk with complex meanings, which necessarily shape the experience of breastfeeding. Our research, investigating the experience of lactation after the loss of an infant, casts a novel light on these meanings. This article analyses the experience of 17 Australian bereaved mothers and 114 health professionals charged with their care. We find that while all the mothers found post‐loss lactation emotionally painful, many also found redemptive meaning in their milk‐production, as a bond with the lost child, as confirmation of their maternal competence and as a life giving substance that they could donate to other needy infants. These complex meanings and positive connotations were at odds with hospital cultures that regard post‐loss lactation as valueless and best dealt with through medical suppression, despite the more complex insights of individual health‐care professions.
Adaptation to climate change in small German municipalities: Sparse knowledge and weak adaptive capacities
Authors: Buschmann Daniel , Koziol Karin , Bausch Thomas , Reinhard Steurer 
Published: October 2022

AbstractUnderstanding local adaptation to climate change is critical for the overall success of adaptation practices in Europe and around the world. Although it becomes more urgent by the day, existing literature does not adequately touch upon the topic of climate adaptation in small municipalities. This article addresses this gap. It explores whether adaptation measures in small municipalities are overlooked in research focused on other aspects of urban environment, or whether such measures are indeed inadequate. Based on a large quantitative survey among Bavarian municipalities (n = 401), we conducted 11 qualitative case studies to answer the following two questions. First, how active are small municipalities in Bavaria, Germany, in climate change adaptation? Second, why and how do municipal adaptation frontrunners implement adaptation measures and what lessons can we learn from their experience? Our findings confirm that small municipalities rarely adapt to climate change, and when they do, their actions usually target water‐related issues. Most often measures are responsive and pragmatic, instead of being preventive and transformative. The fact that the small municipality representatives that we have interviewed were not able to distinguish between adaptation and mitigation measures clearly illustrates the lack of local adaptation capacities. We conclude that national funding for municipal adaptation coordinators or networks is a promising way to improve local capacities.
Determinant factors associated with the use of evidence‐based dietetics practice among registered dietitian nutritionists
Authors: Van Horn Leslie Thompson , Wright Lauri , Arikawa Andrea Y. , Sealey‐Potts Claudia , Hamadi Hanadi 
Published: October 2022

AbstractAimsThere is a lack of research assessing perceived and actual evidence‐based dietetics practice knowledge among registered dietitian nutritionists. This cross‐sectional research examined the association between determinant factors (i.e., education attainment) and objective knowledge (i.e., quiz items) of evidence‐based dietetics practices. Other determinant factors associated with perceived knowledge and skill, attitudes, behaviours and outcomes related to evidence‐based dietetics practice were also assessed. Perceived knowledge items were compared to objective knowledge items to evaluate the accuracy of self‐assessed evidence‐based dietetics practice knowledge among dietitians in the United States.MethodsA modified and adapted evidence‐based practice survey was emailed to registered dietitian nutritionists in the United States via the Commission on Dietetic Registration database between November and December 2020. Analysis of variance assessed the relationship between highest degree held and actual knowledge of evidence‐based dietetics practices. Multiple linear regression and ordinal logistic regression determined participant‐level characteristics associated with survey subscales and survey items, respectively. Pearson's correlation coefficient evaluated the relationship between subjective and objective items.ResultsFour hundred and eighty‐two dietitians completed the survey. Each increase in degree type was associated with an increase in objective knowledge score (all comparisons p < 0.001). Other determinants included recency of degree completion and peer‐reviewed publications. Moderate positive associations (r = 0.35, p < 0.001) were found between subjective and objective measures.ConclusionGraduate‐level education, recency of degree completion and peer‐reviewed publications were supportive of evidence‐based dietetics practice‐related outcomes. Future research should evaluate the efficacy of training, particularly among those further from their highest completed degree.
Disentangling microstructure and environmental conditions in high‐altitude Andean microbialite systems (Catamarca, Argentine Puna)
Authors: Della Vedova Micaela , Villafañe Patricio G. , Cónsole‐Gonella Carlos , Bahniuk Rumbelsperger Anelize , Fadel Cury Leonardo , Horta Luis R. , Farías María E. 
Published: October 2022

AbstractThe study of microbialites development is a key tool to understand environmental pathways during deposition. We provide a detailed analysis of modern Central Andean microbialites from high‐altitude lakes. The stratigraphic record of Turquesa Lake shows a significant short‐term recolonization by microbialite‐producing microorganisms during environmental stress. Far from a crisis paradigm, the coasts and paleocoasts of Turquesa lake exhibit three microbialitic buildups formed along different stages, providing a good study case of biological resilience of these systems in harsh environments. The MI and MII microbialite buildups occupied two paleocoasts. Both are composed of oncoids with micritic to microsparitic textures. Morphological, textural and mineralogical similarities between the two buildups suggest that they were formed at different times, but under very similar environmental conditions. The microorganisms that produced the microbialitic buildup MIII are currently colonizing the coast of this lake. The previous oncoid morphology change to a parallel micritic–spartic lamination. This remarkable changes in the microstructure can be explained by an important environmental change caused by the isolation of the Peinado Lake, and a subsequently microorganism adaptation. This microbialite structures can be proposed as an interesting modern analogue for environmental changes along the geological record.
Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling
Authors: Wang Jing , Li Shuanghui , Zhang Xiujuan , Zhu Ning , Yiminniyaze Ruzetuoheti , Dong Liang , Li Chengwei , Gulinuer Wumaier , Xia Jingwen , Li Jing , Zhou Daibing , Liu Xinning , Zhang Youzhi , Zhang Yuanyuan , Li Shengqing 
Published: October 2022

AbstractBackgroundTo reveal the function of protein tyrosine phosphatase‐L1 (PTPL1) in lung adenocarcinoma.MethodsLung cancer cell lines were transfected with short hairpin RNA against PTPL1 (shPTPL1 group) or negative control (shmock group). Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blotting were used to verify the transfection efficacy. Cell proliferation was analyzed by ethynyldeoxyuridine (EdU), Cell counting kit 8 (CCK8), and colony formation assay after PTPL1 or PTPL1 and yes‐associated protein (YAP1) knockdown. The effect of PTPL1 on tumor growth was examined in a xenograft lung cancer model.ResultsPTPL1 was downregulated in various types of lung cancer cell lines. The EdU, CCK8, colony formation assays and investigation using a xenograft lung cancer model indicated that PTPL1 knockdown increased the proliferation of lung cancer cells. Mechanistically, PTPL1 knockdown induced the activation of the Proto‐oncogene tyrosine‐protein kinase SRC (Src)/Extracellular regulated MAP kinase (ERK) pathway and thereby promoted yes‐associated protein (YAP1) nuclear translocation and activation.ConclusionsIn our study, PTPL1 played a crucial suppressive role in the pathogenesis of lung cancer potentially through counteracting the Src/ERK/YAP1 pathway.
Predictive value of early kinetics of ctDNA combined with cfDNA and serum CEA for EGFR‐TKI treatment in advanced non‐small cell lung cancer
Authors: Zheng Jie , Wang Yubo , Hu Chen , Zhu Mengxiao , Ii Jianghua , Lin Caiyu , Lu Conghua , Dou Yuanyao , Zhao Chenlong , Zhang Yimin , Wu Di , Li Li , Tang Huan , He Tingting , Pan Chunxiao , Han Rui , He Yong 
Published: October 2022

AbstractBackgroundCirculating tumor DNA (ctDNA) has made a breakthrough as an early biomarker in operable early‐stage cancer patients. However, the function of ctDNA combined with cell‐free DNA (cfDNA) as a predictor in advanced non‐small cell lung cancer (NSCLC) remains unknown. Here, we explored its potential as a biomarker for predicting the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) in patients with advanced NSCLC.MethodsA retrospective analysis was undertaken. Plasma collected from 51 patients with advanced NSCLC prior to and serially after starting treatment with EGFR‐TKIs was analyzed by next‐generation sequencing (NGS). The performance of ctDNA, cfDNA, and combining ctDNA with cfDNA were evaluated for their ability to predict survival outcomes.ResultsPatients with early undetectable ctDNA and increasing cfDNA had a markedly better progression‐free survival (PFS) (p < 0.001) and overall survival (OS) (p = 0.001) than those with early detectable ctDNA and decreasing cfDNA. Patients with early ctDNA clearance were more likely to have the ctDNA persistent clearance (p = 0.006). The early clearance rate of ctDNA in the normal carcinoembryonic antigen (CEA) group was significantly higher than in the low and high groups (p = 0.028). Patients with greater CEA decline had a higher early clearance rate of ctDNA than those with minor CEA change (p = 0.016).ConclusionsWe based this study on ctDNA and cfDNA, explored its prognostic predictive ability, and combined CEA to monitor EGFR‐TKI efficacy. This study may provide new perspectives and insights into the precise treatment strategies for NSCLC patients.
Clinicopathological analysis of a superior sulcus tumor treated by salvage surgery after concurrent definitive chemoradiotherapy followed by durvalumab: A case report
Authors: Funaki Soichiro , Ose Naoko , Kimura Toru , Kanou Takashi , Fukui Eriko , Shintani Yasushi 
Published: October 2022

AbstractSurgical treatment of superior sulcus tumors (SSTs) is clinically challenging. Definitive chemoradiotherapy (CRT) is a standard treatment for SST. In operable cases, multimodal therapy (CRT followed by surgery) is another option, at least for experienced institutions. Immune checkpoint inhibitors (ICIs) have recently been developed, and several clinical trials have investigated definitive CRT followed by ICIs for consolidation or maintenance therapy of unresectable local advanced non‐small cell lung cancer (NSCLC), including SSTs. Clinical studies of salvage surgery after CRT followed by ICIs are also ongoing. However, the clinical outcomes of salvage surgery after multimodal therapies and histopathological analyses of surgical specimens after such treatments remain unclear. Here, we report the case of a patient with SST comprising squamous cell carcinoma with invasion of the second to third rib and vertebrae who underwent salvage surgery after concurrent definitive CRT followed by the ICI durvalumab, and show the results of clinicopathological analyses of the resected specimen.
Making and Mastering Violent Environments: Following the Infrastructures of Accumulation in Coastal Louisiana
Authors: Phillips Rachel , Soederberg Susanne 
Published: October 2022

AbstractLouisiana’s coastal wetlands have been disappearing at an alarming rate over the past several decades, with the greatest harm experienced by vulnerable populations (poor and racialised residents). It was not until 2005 that the state legislature responded with a much‐lauded Master Plan tasked with integrating the construction of new flood control infrastructure with wetland restoration. Seeking to unsettle this initiative, we develop a historical‐geographical materialist approach to follow the entanglements between infrastructural production and capital accumulation in Louisiana over the past several hundred years. In so doing, we present a two‐fold argument: that the making and mastering infrastructural violence has always been part of the historical unfolding of the socio‐spatial dynamics of capitalism; and that infrastructural development has played an integral role in this duality at every historical turn. The capitalist state, at both the federal and state levels, has played a vital role in producing and controlling this violence.
The association between steatosis and liver damage in transfusion‐dependent beta thalassaemia patients
Authors: Padeniya Padmapani , Ediriweera Dileepa , De Silva Arjuna P. , Niriella Madunil , Premawardhena Anuja 
Published: October 2022

SummaryNon‐alcoholic fatty liver disease (NAFLD) is a global health problem. Iron is the leading cause of liver damage in patients with transfusion‐dependent thalassaemia (TDT), and data on the contribution of NAFLD to liver damage in TDT is lacking. Forty‐five heavily transfused TDT patients who did not have biochemical or ultrasonic evidence of liver cirrhosis were evaluated for effects of iron overload, including the presence of diabetes mellitus, hypogonadism, serum ferritin, R2‐MRI‐liver, and liver enzymes alanine aminotransferase and aspartate aminotransferase. Liver fibrosis and steatosis were estimated using transient elastography (TE). Nine (20%) patients had significant steatosis (S1), and their body mass index (BMI) and liver fibrosis scores were higher than in patients without significant steatosis (S0) (p = 0.03 and p = 0.004, respectively). On regression analysis, the controlled attenuation parameter (CAP) score (i.e., degree of liver steatosis) was associated only with increasing BMI. The TE score (i.e., degree of liver fibrosis) was associated with increasing age, CAP score, male gender, and presence of diabetes. Neither liver steatosis nor fibrosis showed significant association with the liver iron concentration or iron‐related organ damage (hypogonadism). In this cohort of TDT patients, steatosis of the liver, which is associated with increasing BMI, appeared to increase the risk of liver fibrosis.
Ribonucleoprotein transport in Negative Strand RNA viruses
Authors: Diot Cédric , Cosentino Gina , Rameix‐Welti Marie‐Anne 
Published: October 2022

AbstractNegative‐sense, single‐stranded RNA (‐ssRNA) viruses comprise some of the deadliest human pathogens (Ebola, rabies, influenza A viruses etc.). Developing therapeutic tools relies on a better understanding of their multiplication cycle. For these viruses, the genome replication and transcription activities most‐often segregate in membrane‐less environments called inclusion bodies (IBs) or viral factories. These “organelles” usually locate far from the cell surface from where new virions are released, and ‐ssRNA viruses do not encode for transport factors. The efficient trafficking of the genome progeny toward the cell surface is most often ensured by mechanisms co‐opting the cellular machineries.In this review, for each ‐ssRNA viral family, we cover the methods employed to characterize these host‐virus interactions, the strategies used by the viruses to promote the virus genome transport, and the current gaps in the literature. Finally, we highlight how Rab11 has emerged as a target of choice for the intracellular transport of ‐ssRNA virus genomes.
The utilization and safety of apixaban for therapeutic anticoagulation in heart transplant population requiring routine endomyocardial biopsies
Authors: Lindauer Kristen E. , Ingemi Amanda I. , McMahon Megan R. , Lichvar Alicia , Baran David A. , Cameron Chad , Badiye Amit , Sawey Edward J. , Old Wayne , Yao Andrew , Yehya Amin , Herre John M. 
Published: October 2022

AbstractPurposeRoutine endomyocardial (EM) biopsies pose a challenge in the management of heart transplant recipients requiring anticoagulation. Apixaban is a direct‐acting oral anticoagulant (DOAC) with a short half‐life allowing for brief interruptions of anticoagulation for procedures. The study objective was to determine the safety and efficacy of apixaban in heart transplant patients undergoing EM biopsies.MethodsThis retrospective case series evaluated patients with a heart transplant from April 1, 2017 to July 30, 2020 who were treated with apixaban within 90 days post‐transplant. The primary outcome was the occurrence of a bleeding or thrombotic event.ResultsA total of 12 patients with >100 biopsies were included. The median age was 54 years (IQR 37–59) with a mean weight of 91 ± 20 kg. There were no bleeding or thrombotic events. During therapy, patients underwent an average of eight biopsies. The median time from transplant to initiation of apixaban was 39.5 days (range 9–77). Therapy was maintained without any need for reversal for a median of 276 days (IQR 45–245).ConclusionsApixaban is safe to use for anticoagulation of heart transplant recipients undergoing routine biopsies. Using apixaban allows for a short interruption of therapeutic anticoagulation to accommodate a biopsy without increased risk of bleeding.