bluuebunny/crossref_metadata_2025_split huggingface dataset:
Models for the evolution of seamounts
Authors: Wessel Paul , Watts Anthony B , Kim Seung-Sep , Sandwell David T 
Published: July 2022

SUMMARY
Seamounts are volcanic constructs that litter the seafloor. They are important for understanding numerous aspects of marine science, such as plate tectonics, the volcanic melt budget, oceanic circulation, tsunami wave diffraction, tidal energy dissipation and mass wasting. Geometrically, seamounts come in many sizes and shapes, and for the purpose of modelling them for morphological, gravimetric or isostatic studies it is convenient to have simple analytical models whose properties are well known. Here, we present a family of seamount models that may be used in such studies, covering both the initial construction phase and later mass-wasting by sectoral collapses. We also derive realistic axisymmetric density variations that are compatible with observed first-order structure from seismic tomography studies.
A multitask encoder–decoder to separate earthquake and ambient noise signal in seismograms
Authors: Yin Jiuxun , Denolle Marine A , He Bing 
Published: July 2022

SUMMARYSeismograms contain multiple sources of seismic waves, from distinct transient signals such as earthquakes to continuous ambient seismic vibrations such as microseism. Ambient vibrations contaminate the earthquake signals, while the earthquake signals pollute the ambient noise’s statistical properties necessary for ambient-noise seismology analysis. Separating ambient noise from earthquake signals would thus benefit multiple seismological analyses. This work develops a multitask encoder–decoder network named WaveDecompNet to separate transient signals from ambient signals directly in the time domain for 3-component seismograms. We choose the active-volcanic Big Island in Hawai’i as a natural laboratory given its richness in transients (tectonic and volcanic earthquakes) and diffuse ambient noise (strong microseism). The approach takes a noisy 3-component seismogram as input and independently predicts the 3-component earthquake and noise waveforms. The model is trained on earthquake and noise waveforms from the STandford EArthquake Dataset (STEAD) and on the local noise of seismic station IU.POHA. We estimate the network’s performance by using the explained variance metric on both earthquake and noise waveforms. We explore different neural network designs for WaveDecompNet and find that the model with long-short-term memory (LSTM) performs best over other structures. Overall, we find that WaveDecompNet provides satisfactory performance down to a signal-to-noise ratio (SNR) of 0.1. The potential of the method is (1) to improve broad-band SNR of transient (earthquake) waveforms and (2) to improve local ambient noise to monitor the Earth’s structure using ambient noise signals. To test this, we apply a short-time average to a long-time average filter and improve the number of detected events. We also measure single-station cross-correlation functions of the recovered ambient noise and establish their improved coherence through time and over different frequency bands. We conclude that WaveDecompNet is a promising tool for a broad range of seismological research.
Non-cell-autonomous activation of hedgehog signaling contributes to disease progression in a mouse model of renal cystic ciliopathy
Authors: Hsieh Chia-Ling , Jerman Stephanie Justine , Sun Zhaoxia 
Published: July 2022

Abstract
Polycystic kidney disease (PKD) is a ciliopathy characterized by fluid-filled epithelial cysts in the kidney. Although it is well established that the primary cilium is essential for hedgehog (HH) signaling and HH signaling is abnormally activated in multiple PKD models, the mechanism and function of HH activation in PKD pathogenesis remain incompletely understood. Here we used a transgenic HH reporter mouse line to identify the target tissue of HH signaling in Arl13f/f;Ksp-Cre mutant kidney, in which the cilia biogenesis gene Arl13b is specifically deleted in epithelial cells of the distal nephron. In addition, we used a co-culture system to dissect cross-talk between epithelial and mesenchymal cells in the absence of expanding cysts. Finally, we treated Arl13bf/f;Ksp-Cre mice with the GLI inhibitor GANT61 and analyzed its impact on PKD progression in this model. We found that deletion of Arl13b in epithelial cells in the mouse kidney, in vivo, led to non-cell-autonomous activation of the HH pathway in the interstitium. In vitro, when co-cultured with mesenchymal cells, Arl13b−/− epithelial cells produced more sonic hedgehog in comparison to cells expressing Arl13b. Reciprocally, HH signaling was activated in mesenchymal cells co-cultured with Arl13b−/− epithelial cells. Finally, whole body inhibition of the HH pathway by GANT61 reduced the number of proliferating cells, inhibited cyst progression and fibrosis and preserved kidney function in Arl13bf/f;Ksp-Cre mice. Our results reveal non-cell-autonomous activation of HH signaling in the interstitium of the Arl13bf/f;Ksp-Cre kidney and suggest that abnormal activation of the HH pathway contributes to disease progression.
The Impacts of Transdermal Application of Corticosterone on Toad (Rhinella icterica) Immunity
Authors: Assis Vania Regina , Titon Stefanny Christie Monteiro , Titon Jr. Braz , Gomes Fernando Ribeiro 
Published: July 2022

Abstract
Recent studies have shown that acute physiological increases in endogenous glucocorticoid levels have immunostimulatory effects. Although post-acute stress immunosuppressive effects have also been described, the difference between enhancing and suppressing the immune response seems mediated by the stressor's duration, intensity, and the immune component under analysis. To elicit physiologically relevant corticosterone levels that can be found in Rhinella icterica toads after stressful events (e.g., restraint or captivity) and understand how acute increased glucocorticoid levels of different intensities affect corticosterone and testosterone plasma levels and immune parameters (in vitro plasma bacterial killing ability, neutrophil-to-lymphocyte ratio, and in vivo phagocytosis of peritoneal leukocytes), we submitted toads to the transdermal application of two corticosterone doses (1 and 10 μg). Corticosterone transdermal application increased corticosterone plasma levels with different intensities: 3 times for 1 μg and fourteen times for 10 μg, compared to the vehicle, and the neutrophil-to-lymphocyte ratio increased regardless of the corticosterone dose. However, there was no effect on testosterone levels and bacterial killing ability. Interestingly, both corticosterone doses promoted immunosuppression, decreasing peritoneal leukocytes' phagocytosis activity by 60% for toads receiving the dose of 1µg and 40% for those receiving 10 μg. Our results show the complexity of the relationship between increased corticosterone levels and immunomodulation. The different corticosterone doses promoted increases of distinct magnitudes in corticosterone plasma levels, with the less intense increase in corticosterone levels generating greater cell-mediated immunosuppression. Future studies using different corticosterone doses to achieve and compare physiological vs. pharmacological hormone levels are imperative to understanding these interrelationships between corticosterone and immune response.
Sex Differences in Serotonin 5-HT 1A Receptor Responses to Repeated Restraint Stress in Adult Male and Female Rats
Authors: Philippe Tristan J , Bao Lexia , Koblanski Maya E , Viau Victor 
Published: July 2022

Abstract

Background
Male and female rats were exposed to repeated restraint to determine how changes in serotonin (5-hydroxytryptamine; 5-HT) 1A receptors associate with stress hypothalamic-pituitary-adrenal (HPA) axis habituation.

Methods
In response to 2-hour episodes of restraint, repeated daily for 5 consecutive days, males and females displayed reliable declines in HPA output, indicated by diminished adrenocorticotropin and corticosterone secretory responses. Using the 5-HT 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) as a pharmacological challenge for inducing hypothermia and elevations in plasma corticosterone, males displayed sensitized hypothermal responses after repeated restraint, whereas corticosterone responses to 8-OH-DPAT were enhanced in both sexes following single or repeated exposure.

Results
Only males showed elevations in 5-HT 1A receptor G-protein coupling responses in the dorsal raphe after repeated restraint, whereas only females showed an increase in 5-HT 1A receptor responses in the hippocampus following single or repeated exposure. G-protein coupling responses within both regions correlated positively with 5-HT 1A receptor binding capacity. Thus, despite expressing similar capacities for stress HPA axis habituation, males and females emerged from repeated restraint to show region-specific changes in 5-HT 1A receptor function that may be explained, at least in part, by changes in receptor availability.

Conclusions
Based on the hypothermal and corticosteroid responses to 8-OH-DPAT, the present data suggest that stress habituation is met by an increase in the sensitivity of presynaptic 5-HT 1A receptors in males and by an increase in the sensitivity of a population of postsynaptic receptors in both sexes.
Efficacy of Omadacycline or Vancomycin Combined With Germinants for PreventingClostridioides difficileRelapse in a Murine Model
Authors: Budi Noah D , Godfrey Jared J , Safdar Nasia , Shukla Sanjay K , Rose Warren E 
Published: July 2022

AbstractBackgroundClostridioides difficile infections (CDI) and recurrence (rCDI) are major health care burdens. Recurrence is likely caused by spores in the gastrointestinal tract that germinate after antibiotic therapy. This murine study explores germinant-antibiotic combinations for CDI.MethodsPreviously described murine models were evaluated using C. difficile VPI 10463. The severe model compared omadacycline versus vancomycin in survival, weight loss, clinical scoring, and C. difficile toxin production. The nonsevere model compared these antibiotics with and without germinants (solution of sodium taurocholate, taurine, sodium docusate, calcium gluconate). Additionally, colon histopathology, bile acid analysis, environmental/spore shedding, and 16S sequencing was evaluated.ResultsIn the severe model, omadacycline-treated mice had 60% survival versus 13.3% with vancomycin (hazard ratio [HR], 0.327; 95% confidence interval [CI],.126–.848; P = .015) along with decreased weight loss, and disease severity. In the nonsevere model, all mice survived with antibiotic-germinant treatment versus 60% antibiotics alone (HR, 0.109; 95% CI, .02–.410; P = .001). Omadacycline resulted in less changes in bile acids and microbiota composition. Germinant-treated mice showed no signs of rCDI, spore shedding, or significant toxin production at 15 days.ConclusionsIn murine models of CDI, omadacycline improved survival versus vancomycin. Germinant-antibiotic combinations were more effective at preventing rCDI compared to antibiotics alone without inducing toxin production.
Risk-reducing mastectomy for women with hereditary breast and ovarian cancer (HBOC): analytical results of data from the Japanese Organization of HBOC
Authors: Ohsumi Shozo , Nakamura Seigo , Miyata Hiroaki , Watanabe Chie , Den Hiroki , Arai Masami 
Published: July 2022

AbstractBackgroundRisk-reducing mastectomy is one option for women with hereditary breast and ovarian cancer to reduce the risk of breast cancer.Patients and methodsWe analyzed data of the Japanese Organization of Hereditary Breast and Ovarian Cancer on women who were diagnosed as hereditary breast and ovarian cancer by BRCA germline genetic testing between 2010 and 2019 to reveal the rate and likelihood of risk-reducing mastectomy.ResultsThere were 412 women with BRCA1, 271 with BRCA2 and 4 with both female pathogenic variants. Ninety (13.1%) received risk-reducing mastectomy. The rates of risk-reducing mastectomy were statistically significantly higher in women with BRCA1 pathogenic variants than BRCA2, in women who had breast cancer than those who did not, in women with a breast cancer family history than in those without, in mothers than in those without children, in women who were receiving surveillance with MRI than those who were not and in women who received risk-reducing salpingo-oophorectomy than in those who did not on univariate analyses. The ages when they received the genetic testing were statistically significantly younger in the women receiving risk-reducing mastectomy than those who did not receive it. The women with BRCA1 pathogenic variants, personal history of breast cancer, mothers, those receiving MRI surveillance and younger women were independently significantly more likely to receive risk-reducing mastectomy based on multivariate analysis.ConclusionsThe rate of risk-reducing mastectomy was not high in Japan; however, risk-reducing surgery was approved by the Japanese National Medical Insurance for hereditary breast and ovarian cancer patients with breast and/or ovarian cancer in 2020, so this rate will increase.
Colour evolution of Betelgeuse and Antares over two millennia, derived from historical records, as a new constraint on mass and age
Authors: Neuhäuser R , Torres G , Mugrauer M , Neuhäuser D L , Chapman J , Luge D , Cosci M 
Published: July 2022

ABSTRACT
After core hydrogen burning, massive stars evolve from blue-white dwarfs to red supergiants by expanding, brightening, and cooling within few millennia. We discuss a previously neglected constraint on mass, age, and evolutionary state of Betelgeuse and Antares, namely their observed colour evolution over historical times: We place all 236 stars bright enough for their colour to be discerned by the unaided eye (V ≤ 3.3 mag) on the colour-magnitude-diagram (CMD), and focus on those in the Hertzsprung gap. We study pre-telescopic records on star colour with historically critical methods to find stars that have evolved noticeably in colour within the last millennia. Our main result is that Betelgeuse was recorded with a colour significantly different (non-red) than today (red, B − V = 1.78 ± 0.05 mag). Hyginus (Rome) and Sima Qian (China) independently report it two millennia ago as appearing like Saturn (B − V = 1.09 ± 0.16 mag) in colour and ‘yellow’ (quantifiable as B − V = 0.95 ± 0.35 mag), respectively (together, 5.1σ different from today). The colour change of Betelgeuse is a new, tight constraint for single-star theoretical evolutionary models (or merger models). It is most likely located less than one millennium past the bottom of the red giant branch, before which rapid colour evolution is expected. Evolutionary tracks from MIST consistent with both its colour evolution and its location on the CMD suggest a mass of ∼14 M⊙ at ∼14 Myr. The (roughly) constant colour of Antares for the last three millennia also constrains its mass and age. Wezen was reported white historically, but is now yellow.
Non-Gaussianity constraints with anisotropic μ distortion measurements from Planck
Authors: Rotti Aditya , Ravenni Andrea , Chluba Jens 
Published: July 2022

ABSTRACT
Primordial non-Gaussianity can source μ-distortion anisotropies that are correlated with the large-scale temperature and polarization signals of the cosmic microwave background (CMB). A measurement of μT and μE correlations can therefore be used to constrain it on wavelengths of perturbations not directly probed by the standard CMB anisotropies. We carry out a first rigorous search for μ-distortion anisotropies with Planck data, applying the well-tested constrained ILC component-separation method combined with the needlet framework. We correlate the reconstructed μ map with the CMB anisotropies to derive constraints on the amplitude fNL of the local form bispectrum, specifically on the squeezed configurations with effective wavenumbers $k_s \simeq {740}\, \mathrm{Mpc^{-1}}$ and $k_L \simeq {0.05}\, \mathrm{Mpc^{-1}}$, improving previously estimated constraints by more than an order of magnitude. This enhancement is owing to the fact that we are able to use the full multipole information by carefully controlling biases and systematic effects in the analysis. We also for the first time incorporate constraints from measurements of μE correlations, which further tighten the limits. A combination of the derived Planck μT and μE power spectra yields |fNL| ≲ 6800 (95 per cent c.l.) on this highly squeezed bispectrum. This is only ≃3 times weaker than the anticipated constraint from Litebird. Furthermore we show that a combination of Litebird with Planck can improve the expected future constraint by ${\simeq}20{{\%}}$. These limits can be used to constrain multifield inflation models and primordial black hole formation scenarios, thus providing a promising novel avenue forward in CMB cosmology.
The N2 production rate in comet C/2016 R2 (PanSTARRS)
Authors: Anderson S E , Rousselot P , Noyelles B , Opitom C , Jehin E , Hutsemékers D , Manfroid J 
Published: July 2022

ABSTRACT
Observations of comet C/2016 R2 (PanSTARRS) have revealed exceptionally bright emission bands of N$_2^+$, the strongest ever observed in a comet spectrum. Alternatively, it appears to be poor in CN compared to other comets, and remarkably depleted in H2O. Here, we quantify the N2 production rate from N$_2^+$ emission lines using the Haser model. We derived effective parent and daughter scale lengths for N2 producing N$_2^+$. This is the first direct measurement of such parameters. Using a revised fluorescence efficiency for N$_2^+$, the resulting production rate of molecular nitrogen is inferred to be Q(N2) ∼ 1 × 1028 molecules s−1 on average for 2018 February 11, 12, and 13, the highest for any known comet. Based on a CO production rate of Q(CO) ∼ 1.1 × 1029 molecules s−1, we find Q(N2)/Q(CO) ∼ 0.09, which is consistent with the N$_2^+$/CO+ ratio derived from the observed intensities of N$_2^+$ and CO+ emission lines. We also measure significant variations in this production rate between our three observing nights, with Q(N2) varying by plus or minus 20 per cent according to the average value.
The VMC survey – XLIX. Discovery of a population of quasars dominated by nuclear dust emission behind the Magellanic Clouds
Authors: Pennock Clara M , van Loon Jacco Th , Anih Joy O , Maitra Chandreyee , Haberl Frank , Sansom Anne E , Ivanov Valentin D , Cowley Michael J , Afonso José , Antón Sonia , Cioni Maria-Rosa L , Craig Jessica E M , Filipović Miroslav D , Hopkins Andrew M , Nanni Ambra , Prandoni Isabella , Vardoulaki Eleni 
Published: July 2022

ABSTRACT
Following the discovery of SAGE0536AGN (z ∼ 0.14), with the strongest 10-μm silicate emission ever observed for an active galactic nucleus (AGN), we discovered SAGE0534AGN (z ∼ 1.01), a similar AGN but with less extreme silicate emission. Both were originally mistaken as evolved stars in the Magellanic Clouds. Lack of far-infrared emission, and therefore star formation, implies we are seeing the central engine of the AGN without contribution from the host galaxy. They could be a key link in galaxy evolution. We used a dimensionality reduction algorithm, t-distributed stochastic neighbour embedding with multiwavelength data from Gaia EDR3, VISTA survey of the Magellanic Clouds, AllWISE, and the Australian Square Kilometre Array Pathfinder to find these two unusual AGNs are grouped with 16 other objects separated from the rest, suggesting a rare class. Our spectroscopy at South African Astronomical Observatory/Southern African Large Telescope and literature data confirm at least 14 of these objects are extragalactic (0.13 &lt; z &lt; 1.23), all hosting AGN. Using spectral energy distribution fitter C igale we find that the majority of dust emission ($\gt 70 {{\ \rm per\ cent}}$) in these sources is due to the AGN. Host galaxies appear to be either in or transitioning into the green valley. There is a trend of a thinning torus, increasing X-ray luminosity, and decreasing Eddington ratio as the AGN transition through the green valley, implying that as the accretion supply depletes, the torus depletes and the column density reduces. Also, the near-infrared variability amplitude of these sources correlates with attenuation by the torus, implying the torus plays a role in the variability.
Quasi-periodic Gaussian processes for stellar activity: From physical to kernel parameters
Authors: Nicholson B A , Aigrain S 
Published: July 2022

ABSTRACT
In recent years, Gaussian Process (GP) regression has become widely used to analyse stellar and exoplanet time-series data sets. For spotted stars, the most popular GP covariance function is the quasi-periodic (QP) kernel, whose hyperparameters of the GP have a plausible interpretation in terms of physical properties of the star and spots. In this paper, we test the reliability of this interpretation by modelling data simulated using a spot model using a QP GP, and the recently proposed quasi-periodic plus cosine (QPC) GP, comparing the posterior distributions of the GP hyperparameters to the input parameters of the spot model. We find excellent agreement between the input stellar rotation period and the QP and QPC GP period, and very good agreement between the spot decay time-scale and the length scale of the squared exponential term. We also compare the hyperparameters derived from light and radial velocity (RV) curves for a given star, finding that the period and evolution time-scales are in good agreement. However, the harmonic complexity of the GP, while displaying no clear correlation with the spot properties in our simulations, is systematically higher for the RV than for the light-curve data. Finally, for the QP kernel, we investigate the impact of noise and time-sampling on the hyperparameters in the case of RVs. Our results indicate that good coverage of rotation period and spot evolution time-scales is more important than the total number of points, and noise characteristics govern the harmonic complexity.
The initial magnetic criticality of pre-stellar cores
Authors: Priestley Felix D , Yin Charles , Wurster James 
Published: July 2022

ABSTRACT
Direct observational measurements of the magnetic field strength in pre-stellar cores typically find supercritical mass-to-flux ratios, suggesting that the magnetic field is insufficient to prevent gravitational collapse. These measurements suffer from significant uncertainties; an alternative approach is to utilize the sensitivity of pre-stellar chemistry to the evolutionary history, and indirectly constrain the degree of magnetic support. We combine non-ideal magnetohydrodynamic simulations of pre-stellar cores with time-dependent chemistry and radiative transfer modelling, producing synthetic observations of the model cores in several commonly observed molecular lines. We find that molecules strongly affected by freeze-out, such as CS and HCN, typically have much lower line intensities in magnetically subcritical models compared to supercritical ones, due to the longer collapse time-scales. Subcritical models also produce much narrower lines for all species investigated. Accounting for a range of core properties, ages, and viewing angles, we find that supercritical models are unable to reproduce the distribution of CS and N2H+ line strengths and widths seen in an observational sample, whereas subcritical models are in good agreement with the available data. This suggests that despite presently having supercritical mass-to-flux ratios, pre-stellar cores form as magnetically subcritical objects.