bluuebunny/crossref_metadata_2025_split huggingface dataset:
Materials and technology of mosaics from the House of Charidemos at Halikarnassos (Bodrum, Turkey)
Authors: Rasmussen Kaare Lund , Delbey Thomas , Jørgensen Bjarke , Jensen Kasper Høegh , Poulsen Birte , Pedersen Poul 
Published: May 2022

Abstract
An excavation in 1856 by Charles T. Newton and a re-excavation in 1990–93 by a joint Danish-Turkish team revealed several mosaic floors in a late-antique domus from the fifth century CE, now called the House of Charidemos. Nineteen tesserae from the floor have been analysed by laser ablation inductively coupled plasma mass spectrometry, Raman micro-spectroscopy, scanning electron microscopy with energy dispersive X-ray analysis, and X-ray diffraction. Seven tesserae were made of opaque glass, eleven from various rock/lithic materials, while one of them was a ceramic fragment. This case-study reports the first analyses undertaken of tesserae from late-antique Halikarnassos. The results show the use of recycled Sb–Mn decoloured glass and two types of red glass. A comparison with tesserae from other sites in Anatolia from the same period shows similarities in the base glass composition, but also some particularities of the colouring and opacifying agents used for the mosaic of the House of Charidemos. The characterisation of the stone tesserae shows a homogeneity in the choice of the materials of the same colours, but no certain provenance has been established in the present work mainly due to the lack of comparative materials.

Graphical Abstract
Improved distribution of leg forces after fibular resection and synostosis
Authors: Rahman Tariq , Oleas-Santillan Geovanny , Wee Jinyong , Mackenzie William G. 
Published: May 2022

Abstract
Purpose
Genu varum- a common symptom in achondroplasia- may lead to ankle valgus in children. Ankle valgus may be mitigated by tibiofibular synostosis, but this is not always the case. The mechanical environment around the growth plates plays an important role in ankle valgus. The purpose of this project is 1) to determine the strain through the distal fibular growth plate before and after tibiofibular synostosis, and 2) postulate whether the change in strain affects ankle valgus. This project measured the distal fibular strain in a porcine hind leg model.

Methods
The lower legs of seven pigs were removed, instrumented with strain gauges, and loaded compressively in a material testing machine. Loads were applied at three phases: 1) the intact leg, 2) leg with fibula resected, and 3) leg with fibula resected and tibiofibular synostosis. Mean strains were compared between phases using a mixed affect model. The significance level was adjusted for multiple comparisons using the Bonferroni method.

Results
Phase 1, intact leg, had the highest strain value at 1247.9μɛ. In phase 2, the mean strain was 106.2μɛ. In phase 3, the compressive mean strain dropped to 477.4μɛ, which is 38% of the strain in phase 1. Standard error was 86.8μɛ; p < 0.001.

Conclusion
Results indicate that more of the force through the leg is transmitted through the tibia after fibular resection and tibiofibular synostosis, which improves the balance of forces through the leg.
Patient-specific dosimetry adapted to variable number of SPECT/CT time-points per cycle for $$^{177}$$Lu-DOTATATE therapy
Authors: Vergnaud Laure , Giraudet Anne-Laure , Moreau Aurélie , Salvadori Julien , Imperiale Alessio , Baudier Thomas , Badel Jean-Noël , Sarrut David 
Published: May 2022

Abstract
Background
The number of SPECT/CT time-points is important for accurate patient dose estimation in peptide receptor radionuclide therapy. However, it may be limited by the patient’s health and logistical reasons. Here, an image-based dosimetric workflow adapted to the number of SPECT/CT acquisitions available throughout the treatment cycles was proposed, taking into account patient-specific pharmacokinetics and usable in clinic for all organs at risk.

Methods
Thirteen patients with neuroendocrine tumors were treated with four injections of 7.4 GBq of $$^{177}$$

177

Lu-DOTATATE. Three SPECT/CT images were acquired during the first cycle (1H, 24H and 96H or 144H post-injection) and a single acquisition (24H) for following cycles. Absorbed doses were estimated for kidneys (LK and RK), liver (L), spleen (S), and three surrogates of bone marrow (L2 to L4, L1 to L5 and T9 to L5) that were compared. 3D dose rate distributions were computed with Monte Carlo simulations. Voxel dose rates were averaged at the organ level. The obtained Time Dose-Rate Curves (TDRC) were fitted with a tri-exponential model and time-integrated. This method modeled patient-specific uptake and clearance phases observed at cycle 1. Obtained fitting parameters were reused for the following cycles, scaled to the measure organ dose rate at 24H. An alternative methodology was proposed when some acquisitions were missing based on population average TDRC (named STP-Inter). Seven other patients with three SPECT/CT acquisitions at cycles 1 and 4 were included to estimate the uncertainty of the proposed methods.

Results
Absorbed doses (in Gy) per cycle available were: 3.1 ± 1.1 (LK), 3.4 ± 1.5 (RK), 4.5 ± 2.8 (L), 4.6 ± 1.8 (S), 0.3 ± 0.2 (bone marrow). There was a significant difference between bone marrow surrogates (L2 to L4 and L1 to L5, Wilcoxon’s test: p value < 0.05), and while depicting very doses, all three surrogates were significantly different than dose in background (p value < 0.01). At cycle 1, if the acquisition at 24H is missing and approximated, medians of percentages of dose difference (PDD) compared to the initial tri-exponential function were inferior to 3.3% for all organs. For cycles with one acquisition, the median errors were smaller with a late time-point. For STP-Inter, medians of PDD were inferior to 7.7% for all volumes, but it was shown to depend on the homogeneity of TDRC.

Conclusion
The proposed workflow allows the estimation of organ doses, including bone marrow, from a variable number of time-points acquisitions for patients treated with $$^{177}$$

177

Lu-DOTATATE.
Investigation of ground fissures at Kausaltar, Kathmandu by in-situ testing and spatial geographical mapping
Authors: Shiga Masataka , Konagai Kazuo , Pokhrel Rama Mohan , Ikeda Takaaki 
Published: May 2022

AbstractOn April 25th, 2015, the Gorkha earthquake jolted the central region of Nepal, causing extensive damage to buildings and grounds in the urban areas of Nepal. One embankment section of Kathmandu-Bhaktapur Road, crosses a small valley in the center of the Kathmandu Basin. The earthquake has caused this embankment to deform with its supporting soil. Investigating the mechanism of this ground deformation from the geotechnical and geological viewpoints was deemed necessary to examine possible countermeasures. For this purpose, we conduct several in-situ tests such as microtremor measurements, standard penetration tests, and Multichannel Analysis of Surface Waves. These investigations make two soft soil layers emerge as a causative factor. The estimated 3D soil profile shows that the deformed ground overlaps the area where the weak soil layers are below the groundwater level. The 3D soil profile also suggests that groundwater lowering using existing wells can reduce the water-saturated area by 81%. Carbon dating shows that the causative layer formed before the Paleo-Kathmandu Lake dried up.
Development and content validity of a rating scale for the pain and disability drivers management model
Authors: Naye Florian , Décary Simon , Tousignant-Laflamme Yannick 
Published: May 2022

Abstract
Background
Establishing the biopsychosocial profile of patients with low back pain (LBP) is essential to personalized care. The Pain and Disability Drivers Management model (PDDM) has been suggested as a useful framework to help clinicians establish this biopsychosocial profile. Yet, there is no tool to facilitate its integration into clinical practice. Thus, the aim of this study is to develop a rating scale and validate its content, to rapidly establish the patient’s biopsychosocial profile, based on the five domains of the PDDM.

Methods
The tool was developed in accordance with the principles of the COSMIN methodology. We conducted three steps: 1) item generation from a comprehensive review, 2) refinement of the scale with clinicians’ feedback, and 3) statistical analyses to assess content validity.
To validate the item assessing with Likert scales, we performed Item level-Content Validity Index (I-CVI) analyses on three criteria (clarity, presentation and clinical applicability) with an a priori threshold of > 0.78. We conducted Average-Content Validity Index (Ave-CVI) analyses to validate the overall scale with a threshold of > 0.9.

Results
In accordance with the PDDM, we developed a 5-item rating scale (1 per domain) with 4 score options. We selected clinical instruments to screen for the presence or absence of problematic issues within each category of the 5 domains. Forty-two participants provided feedback to refine the scale’s clarity, presentation, and clinical applicability. The statistical analysis of the latest version presented I-CVI above the threshold for each item (I-CVI ranged between 0.94 and 1). Analysis of the overall scale supported its validation (Ave-CVI = 0.96 [0.93;0.98]).

Conclusion
From the 51 biopsychosocial elements contained within the 5 domains of the PDDM, we developed a rating scale that allows to rapidly screen for problematic issues within each category of the PDDM’s 5 domains. Involving clinicians in the process allowed us to validate the content of the first scale to establish the patient’s biopsychosocial profile for people with low back pain. Future steps will be necessary to continue the psychometric properties analysis of this rating scale.
Sustainability performance indicator trends: a Canadian industry-based analysis
Authors: Coulmont Michel , Berthelot Sylvie , Gagné Vincent 
Published: May 2022

AbstractThis study aims to examine the trends in the sustainability performance indicators disclosed in sustainability reports by Canadian companies. Our sample is comprised of eight companies in four sectors and our observations cover a 19-year period. The results of our analysis show a general increase over time of sustainability performance indicators disclosed, as well as varying degrees of coverage of the three sustainability dimensions. While the focus was more on environmental performance in the early 2000s, social performance indicators, such as employment practices and human rights, have now gained more traction. In addition, the scope of sustainability performance indicators disclosed in sustainability reports reached a plateau around 2010. Our results highlight the need for a standardised approach to sustainability reporting that would help overcome the shortcomings of voluntary initiatives and improve the overall comparability of voluntary reporting mechanisms.
A bibliometric analysis of online faculty professional development in higher education
Authors: Gao Yanjun , Wong Su Luan , Md. Khambari Mas Nida , Noordin Nooreen 
Published: May 2022

AbstractResearch on online faculty professional development (OFPD) in higher education has increased in recent years. As there is, nevertheless, a scarcity of quantitative investigations on research publications in this area, a bibliometric analysis of 248 publications collected from the Scopus database was conducted. Biblioshiny and VOSviewer software tools were used for descriptive and network analyses. The research results showed that the overall trend of publication in this domain increased steadily at an annual growth rate of 14.11% during the past 25 years. Journal of Asynchronous Learning Network and Computers and Education ranked the highest among journals with regard to publication number and citation number, respectively. With a total of 298 citations to his paper, Peter Shea was ranked the most impactful author while Maria Northcote, with five publications, was the most productive. In terms of geographical location of research activity, America played the leading role, with Asia emerging in this field. The publication entitled “A Research Agenda for Online Teacher Professional Development” by Dede et al. topped the list for both total citations and average yearly citations. As to recent trends, teacher professional development through online teaching was emergent partly due to the outbreak of Covid-19. Pedagogy training, online community building, and facilitating online teachers were the themes that researchers favored. The study will contribute toward better understanding of the existing literary landscape of research on OFPD given the potential of OFPD in enhancing faculty’s effectiveness in their classrooms and over the course of their teaching careers.
Medico-legal history taking from the victims of sexual assaults: the role of nurse examiners
Authors: Yesodharan Renjulal , Shehata Shaimaa A. , Jose Tessy Treesa , Hagras Abeer M. , Nayak Vinod 
Published: May 2022

AbstractBackgroundSexual assault examiners provides comprehensive health care to victims of sexual assault. Communication with the victim is important to collect relevant information from the victims. Ineffective communications can cause re-victimization and hamper the medico-legal evidence collection.Main textThis article aims to orient the novice examiner and nurses to the prerequisites of medico-legal history collection, techniques of building trust, establishing rapport, ensuring privacy and confidentiality, taking consent, communicating effectively with the victims of sexual assault, and components of medico-legal history collection.ConclusionsNovice examiners and nurses need to be trained in collecting medico-legal history and evidence. The examiners who conduct the examination should be dedicated to delivering compassionate and high-quality care to individuals who have disclosed sexual assault.
Insecticidal effect of entomopathogenic nematodes and the cell-free supernatants from their symbiotic bacteria against different larval instars of Agrotis segetum (Denis & Schiffermüller) (Lepidoptera: Noctuidae)
Authors: Yüksel Ebubekir , Imren Mustafa , Özdemir Esengül , Bozbuğa Refik , Canhilal Ramazan 
Published: May 2022

Abstract
Background
Entomopathogenic nematodes (EPNs) (Steinernematidae and Heterorhabditidae) and their symbiotic bacteria are pathogenic for a wide range of insect pests and have been used successfully as a biological control agent. Although EPNs are well studied against many agricultural insect pests, the efficacy of their symbiotic bacteria still remains unclear for many insect pests of agricultural importance. In the present study, the virulence of native EPN isolates and their cell-free supernatants of symbiotic bacteria were tested against the 3rd and 4th larval instars of Agrotis segetum (Denis & Schiffermüller) (Lepidoptera: Noctuidae) under laboratory conditions (25 ± 1 °C and R.H. 60%).

Results
The 4th instar larvae were more susceptible to infective juveniles (IJs) and mortalities over (95%) were achieved by all tested EPN isolates at the concentration of 100 IJs/cm2 after 72 hrs of exposure. The cell-free supernatants were more effective against the 3rd instar larvae and the highest mortalities were recorded as 42 and 60% in the contact and leaf disc bioassays, respectively.

Conclusion
The results indicated that the cell-free supernatants can be an ideal application for young larval stages of A. segetum. However, further studies are required to test the effectiveness of both EPNs and the cell-free supernatants of their symbiotic bacteria in field conditions.
Photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) in oral manifestations of patients infected by Sars-CoV-2: systematic review and meta-analysis
Authors: Pacheco Juliano Abreu , Molena Kelly Fernanda , Martins Camila Raíssa Oliveira Gontijo , Corona Silmara Aparecida Milori , Borsatto Maria Cristina 
Published: May 2022

Abstract
Background
In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China, and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed.

Main body
This systematic review and meta-analysis aimed to critically assess the clinical evidence on the use of photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) for the treatment of oral lesions in patients infected with Sars-Cov-2. The literature extracted from electronic databases such as PubMed, Medline, CINAHL, and Google Scholar was screened for eligibility, and relevant articles were included. The review is limited to manuscripts published in English, Spanish and Portuguese language between December 2019 and October 2021. A total of 5 articles with 11 cases retracting PBMT and aPDT as therapeutic strategies for the regression of oral lesions and painful symptoms. The results show favoring the associated use of PBMT with aPDT (P = 0.004), and the isolated use of PBMT with the result of significant “P = 0.005” and good confidence interval (7.18, 39.20) in ulcerative lesions, herpetic, aphthous, erythematous, petechiae and necrotic areas.

Conclusions
PBMT and aPDT could be effective in the treatment of oral lesions of patients infected with Sars-Cov-2 in a short period of time; however, more long-term randomized clinical trials studies are needed to define the therapeutic strategy.
Self-driven directional dehydration enabled eco-friendly manufacture of chrome-free leather
Authors: Huang Yawen , Xiao Hanzhong , Pu Haoliang , Xue Ni , Hao Baicun , Huang Xin , Shi Bi 
Published: May 2022

AbstractManufacture of eco-friendly chrome-free leather is of great significance for realizing sustainable development of leather industry. Conventional tanning theory believes that it is impossible to convert raw hide to leather without the utilization of cross-linking agent (e.g., chrome salts) among collagen fibers in raw hide. Here, we developed a brand-new leather manufacture strategy that relied on the composite dehydration media enabled self-driven directional dehydration mechanism to accomplish chrome-free leather manufacture for the first time, rather than followed the classic cross-linking mechanism that has been obeyed for more than one century in leather industry. We demonstrated that the essence of leather making is to regulate the water content in raw hide rather than to form cross-linkage among collagen fibers. The composite dehydration media comprised of anhydrous ethanol and molecular sieves (3A activated zeolite powder) successfully guaranteed continuous self-driven directional dehydration of raw hide by establishing stable water concentration gradient between raw hide and ethanol, which significantly increased the dispersity of collagen fibers in raw hide (with the water content reduced from 56.07% to 5.20%), thus obtaining chrome-free leather that is more ecological than chrome-tanned leather due to the elimination of any tanning agent. The as-prepared chrome-free leather exhibited outstanding tear force (174.86 N), tensile strength (24.56 N mm−2), elongation at break (53.28%) and dry-thermal stability, superior to chrome-tanned leather. Notably, the used composite dehydration media was recyclable for chrome-free leather manufacture, therefore facilitating an environmentally benign leather manufacture process. Our investigations are expected to open up a new conceptual leather making strategy that is applicable for realizing substantial manufacture of eco-friendly leather.
Graphical abstract
Suicidal ideation and behavior among subjects with substance abuse disorder related to pregabalin
Authors: Ibrahim Abdallah Saad , Bayomy Reem Hassan , Hussein Ramadan Abdelbr , Yousef Usama Mahmoud , Elazab Waleed Eleraky 
Published: May 2022

Abstract
Background
Although pregabalin abuse is increasing worldwide and may be associated with increased suicidal ideation and behavior, few studies were done in Egypt searching for the effect of pregabalin on suicide. Eighty-three patients meeting DSM-IV criteria for substance abuse disorders related to pregabalin were identified from the addiction clinic of EL Khanka Psychiatric Hospital in Egypt for this observational cross–sectional study. We intended to assess suicidal ideation and behavior in patients with substance abuse disorder related to pregabalin and to identify the effects of other comorbid substances of abuse. All participants were subjected to semi-structured interview designed to collect and identify the socio-demographic data and patterns of substances 'use ,The Structured Clinical Interview for DSM-IV Axis I Disorders to diagnose patients with substance abuse disorder “related to pregabalin,” Beck Scale for Suicidal Ideation for assessment of suicidal ideation and behavior and urine screening test for pregabalin and other substances of abuse.

Results
Most of participants used pregabalin continuously {86.7%}. More than seventy nine percent of the patients abused both pregabalin and other substances, tramadol 67.4%, heroin 66.3%, cannabis 65.1%, other drugs 44.6%, and benzodiazepines 27.7%. Screening urine test was positive in 62.7% of participants most frequently was heroin 41% and cannabis 34.9%. No suicidal ideation was found in 67.4%, 19.3% had low risk of suicide, and 13.3% had high risk of suicide so total participants who had suicidal ideation were 32.6%. There was statistical significant increase in risk of suicide among patients who were continuously abusing pregabalin and who had positive pregabalin urine test. There was significant positive correlation between Beck Suicidal Ideation score and duration of abusing pregabalin, maximum and daily dose of pregabalin. Also, there was a statistical significant relation between suicidal ideation and associated tramadol abuse and this was positively correlated with dose and duration of tramadol abuse.

Conclusions
About one third of patients abusing pregabalin had a risk of suicide and this risk increased with associated tramadol abuse so pregabalin abuse is dangerous like other substances of abuse and must be used with caution under strict medical supervision