bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling
Authors: He Zhu-qing , Huan Peng-fei , Wang Li , He Jian-cheng 
Published: March 2022

AbstractPaeoniflorin (PF) has numerous benefits, including anti-inflammatory and anti-apoptosis effects. However, it is not clear if it has neuroprotective effects against cognitive impairment (CI) in Parkinson’s disease (PD). Through network pharmacology, we identified probable targets as well as signal pathways through which PF might affect CI in PD. Then, we experimentally validated our findings. The core genes of the protein-protein interactions (PPI) network include MAPK8 (JNK), TP53, CASP3 (caspase-3), postsynaptic density protein-95 (PSD-95) and synaptophysin (SYN). Pathway enrichment analysis revealed that genes involved in apoptosis and mitogen-activated protein kinase (MAPK) signaling were significantly enriched. Because JNK is a key mediator of p53-induced apoptosis, we wondered if JNK/p53 pathway influences the effects of PF against apoptosis in mouse model of PD. Molecular docking analysis showed that PF had good affinity for JNK/p53. The results of the experiments indicated that PF ameliorated behavioral impairments and upregulated the expression of the dopamine (DA) neurons, suppressed cell apoptosis in substantia nigra pars compacta (SNpc) of PD. Additionally, PF improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the CA1 and CA3, and upregulating PSD-95 as well as SYN protein levels. Similar protective effects were observed upon JNK/p53 pathway inhibition using SP600125. Overall, PF improved CI in PD by inhibiting JNK/p53 pathway.
When normal is normative: The ethical significance of conforming to reasonable expectations
Authors: Breakey Hugh 
Published: March 2022

AbstractPeople give surprising weight to others’ expectations about their behaviour. I argue the practice of conforming to others’ expectations is ethically well-grounded. A special class of ‘reasonable expectations’ can create prima facie obligations even in cases where the expectations arise from contingent pre-existing practices, and the duty-bearer has not created them, or directly benefited from them. The obligation arises because of the substantial goods that follow from such conformity—goods capable of being endorsed from many different ethical perspectives and implicating key moral factors such as consent, fairness, respect, autonomy, and reciprocity. Given the innumerable situations where such expectations can arise, their ethical significance is critical both practically and philosophically.
Elucidating Active CO–Au Species on Au/CeO2(111): A Combined Modulation Excitation DRIFTS and Density Functional Theory Study
Authors: Weyel Jakob , Ziemba Marc , Hess Christian 
Published: March 2022

AbstractIn this work we elucidate the main steps of the CO oxidation mechanism over Au/CeO2(111), clarifying the course of CO adsorption at a broad variety of surface sites as well as of transmutations of one CO species into another. By combining transient spectroscopy with DFT calculations we provide new evidence that the active centers for CO conversion are single gold atoms. To gain insight into the reaction mechanism, we employ Modulation Excitation (ME) DRIFT spectroscopy in combination with the mathematical tool of Phase Sensitive Detection to identify the active species and perform DFT calculations to facilitate the assignments of the observed bands. The transient nature of the ME-DRIFTS method allows us to sort the observed species temporally, providing further mechanistic insight. Our study highlights the potential of combined transient spectroscopy and theoretical calculations (DFT) to clarify the role of adsorbates observed and to elucidate the reaction mechanism of CO oxidation over supported gold and other noble-metal catalysts.
Token replacement-based data augmentation methods for hate speech detection
Authors: Madukwe Kosisochukwu Judith , Gao Xiaoying , Xue Bing 
Published: March 2022

AbstractHate speech detection mostly involves the use of text data. This data, usually sourced from various social media platforms, have been known to be plagued with numerous issues that result in a reduction of its quality and hence, the quality of the trained models. Some of these issues are the lack of diversity and the diminutive class of interest in the dataset which results in overfitted models that do not generalize well on other or newly collected data. The different ways of handling these issues include augmenting the data with diverse samples, engineering non-redundant features or designing robust classification models. In this study, the focus is on the data augmentation aspect. Data augmentation is a popular method for improving the quality of existing datasets by generating synthetic samples that mimic the distribution of the original samples. There is a lack of extensive studies on how hate speech texts respond to varying textual data augmentation techniques and methods. Specifically, we provide further insight into the token replacement method of textual data augmentation by performing empirical studies that investigate which embedding method(s) is a robust source of synonym for replacement process, what effective method(s) can be used to select words to be replaced, and how to confirm if the label within each class is preserved. Our proposed methods, validated on two commonly used hate speech datasets affected by a known lack of diversity and diminutive class of interest issues, significantly improve classification performance and provides insights into token replacement methods.
Training on Reporting and Data System (RADS) for Somatostatin-Receptor Targeted Molecular Imaging Can Reduce the Test Anxiety of Inexperienced Readers
Authors: Weich Alexander , Higuchi Takahiro , Bundschuh Ralph A. , Lapa Constantin , Serfling Sebastian E. , Rowe Steven P. , Pomper Martin G. , Herrmann Ken , Buck Andreas K. , Derlin Thorsten , Werner Rudolf A. 
Published: March 2022

Abstract

Purpose
For somatostatin receptor (SSTR)-positron emission tomography/computed tomography (PET/CT), a standardized framework termed SSTR-reporting and data system (RADS) has been proposed. We aimed to elucidate the impact of a RADS-focused training on reader’s anxiety to report on SSTR-PET/CT, the motivational beliefs in learning such a system, whether it increases reader’s confidence, and its implementation in clinical routine.

Procedures
A 3-day training course focusing on SSTR-RADS was conducted. Self-report questionnaires were handed out prior to the course (Pre) and thereafter (Post). The impact of the training on the following categories was evaluated: (1) test anxiety to report on SSTR-PET/CT, (2) motivational beliefs, (3) increase in reader’s confidence, and (4) clinical implementation. To assess the effect size of the course, Cohen’s d was calculated (small, d = 0.20; large effect, d = 0.80).

Results
Of 22 participants, Pre and Post were returned by 21/22 (95.5%). In total, 14/21 (66.7%) were considered inexperienced (IR, < 1 year experience in reading SSTR-PET/CTs) and 7/21 (33.3%) as experienced readers (ER, > 1 year). Applying SSTR-RADS, a large decrease in anxiety to report on SSTR-PET/CT was noted for IR (d =  − 0.74, P = 0.02), but not for ER (d = 0.11, P = 0.78). For the other three categories motivational beliefs, reader’s confidence, and clinical implementation, agreement rates were already high prior to the training and persisted throughout the course (P ≥ 0.21).

Conclusions
A framework-focused reader training can reduce anxiety to report on SSTR-PET/CTs, in particular for inexperienced readers. This may allow for a more widespread adoption of this system, e.g., in multicenter trials for better intra- and interindividual comparison of scan results.
The Contribution of Forest Extraction to Income Diversification and Poverty Alleviation for Indonesian Smallholder Cattle Breeders
Authors: Nugroho Eko , Ihle Rico , Heijman Wim , Oosting Simon J. 
Published: March 2022

AbstractSmallholder farmers in developing countries often lack resources. They rely mostly on extensive production approaches, such as cattle keeping and resort more to extracting forest resources at no charge. Our objective is to assess the relationship between the diversification of income sources, poverty and livelihood capital for smallholder farm households which combine cattle farming with forest extraction. We collected 600 surveys from Indonesian farmers specialized along the cattle rearing supply chain (464 breeders, 66 feeders and 70 mixed breeder-feeders). We found no correlation between poverty and income diversification. Cattle breeders have been found to rely most on forest resources. Distance to cropland and forest correlated positively, whereas their education level correlated negatively with income diversification. Feeders who were owning other livestock, were a member of a forest user group and owned some modest capital like a motorbike showed increased income diversification. Crops are the most important source of income for farmers, whereas cattle keeping and forest extraction play a role in income diversification. Increasing ecological pressure caused by forest extraction due to expanding cattle production could be best avoided by extending those parts of the cattle sector that use forest resources in a sustainable manner, for instance, through silvopastural systems or agroforestry so that incomes of poor farmers get more diversified and, therefore stabilized.
Postcraniotomy Headache: Etiologies and Treatments
Authors: Bello Corina , Andereggen Lukas , Luedi Markus M. , Beilstein Christian M. 
Published: March 2022

Abstract
Purpose of Review
Postcraniotomy headache (PCH) is a highly underappreciated and very common adverse event following craniotomy.

Recent Findings
Analgetic medication with opioids often interferes with neurologic evaluation in the acute phase of recovery and should be kept to a minimal, in general, in the treatment of chronic pain as well. We provide an update on the latest evidence for the management of acute and chronic PCH.

Summary
Especially in the neurosurgical setting, enhanced recovery after surgery protocols need to include a special focus on pain control. Patients at risk of developing chronic pain must be identified and treated as early as possible.
Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway
Authors: Luo Junchao , Zhu Senbo , Tong Yu , Zhang Yin , Li Yong , Cao Li , Kong Mingxiang , Luo Min , Bi Qing , Zhang Qiong 
Published: March 2022

Abstract
Osteoplastic precursors are critical for fracture repair and bone homeostasis maintenance. Cerium oxide nanoparticles (CeO2 NPs) can promote the osteogenic differentiation of mesenchymal stem cells and secrete vascular endothelial growth factors. However, little is known about its role in precursor osteoblasts; therefore, we further investigated the effect and mechanism of CeO2 NPs in precursor osteoblasts. Cell counting kit-8 analysis was utilized to detect the toxicity of CeO2 NPs on MC3T3-E1 mouse osteogenic precursor cells. Then, alizarin red S staining was employed to assess the degree of extracellular matrix mineralization, and quantitative real-time polymerase chain reaction analysis was performed to measure the levels of osteogenesis-related genes. To identify differentially expressed genes, mRNA-sequencing was performed. Subsequently, GO and KEGG analyses were deployed to identify the major downstream pathways, whereas Western blot was used for verification. CeO2 NPs significantly enhanced the ability of MC3T3-E1 precursor osteoblasts to enhance matrix mineralization and increased the expression of osteogenic genes such as runt-related transcription factor 2, collagen Iα1, and osteocalcin. Pathway analysis revealed that CeO2 NPs enhanced the nuclear translocation of β-catenin and activated the Wnt pathway by promoting family with sequence similarity 53 member B/simplet expression, while Western blot analysis indicated the same results. After using a Wnt pathway inhibitor (KYA1797K), the simulative effect of CeO2 NPs was abolished. This study revealed that CeO2 NPs promoted MC3T3-E1 precursor osteoblast differentiation by activating the Wnt pathway.
Human Urine-Derived Stem Cells Improve Partial Bladder Outlet Obstruction in Rats: Preliminary Data and microRNA-mRNA Expression Profile
Authors: Tu Menjiang , Wang Rui , Zhu Pei , Wang Qingqing , Sun Bishao , Lu Keshi , Zhang Jiawei , Xie Weijie , Guo Huan , Li Shulin , Wu Yuqi , Wang Xiangwei 
Published: March 2022

AbstractPartial bladder outlet obstruction (pBOO) often results in bladder tissue inflammation and remodeling. As human urine-derived stem cells (USCs) have demonstrated therapeutic benefits, we used a rat model to investigate the effect of USCs on bladder function and explore the miRNA and gene expression profiles in bladder tissue using RNA sequencing. Eighteen rats were assigned to a sham surgery group, pBOO group, and pBOO+USC group (six biweekly treatments). Routine urodynamic monitoring, analysis of detrusor muscle strips, and pathophysiology assessments were conducted. Finally, altered miRNA and mRNA expression profiles of bladder tissue were examined using RNA sequencing and bioinformatics analysis. After USC treatment, elevated bladder compliance and maximal voiding pressure, declined end filling pressure and voided volume, and improved detrusor muscle contractility and carbachol sensitivity were found. Histology and TUNEL assay revealed reduced collagen deposition and muscle cell apoptosis in bladder tissue. The differential expression of eight miRNAs was reversed by USC treatment. Two large nodes (miR-142 and miR-9a) were identified in the miRNA-gene interaction network in the USC-treated group. The Kyoto Encyclopedia of Genes and Genomes analysis revealed enrichment of multiple significant pathways, including those involved in necroptosis and cytokine-cytokine receptor interactions. This is the first study to demonstrate the protective effect of USCs on bladder function and remodeling in pBOO rats. The miRNA and mRNA expression levels differed in the bladder of pBOO rats with and without USC treatment. Although the mechanism underlying these effects has not been fully elucidated, necroptosis and cytokine-cytokine receptor interaction-related pathways may be involved.
Graphical abstract
SEOM clinical guidelines for the prophylaxis of infectious diseases in cancer patients (2021)
Authors: Echavarria Isabel , Carrión Galindo J. Rafael , Corral Jesús , Diz Taín María Pilar , Henao Carrasco Fernando , Iranzo González-Cruz Vega , Mielgo-Rubio Xabier , Quintanar Teresa , Rivas Corredor Carlos , Pérez Segura Pedro 
Published: March 2022

AbstractInfections are still a major cause of morbi-mortality in patients with cancer. Some of these infections are preventable through specific measures, such as vaccination or prophylaxis. This guideline aims to summarize the evidence and recommendations for the prevention of infections in cancer patients, devoting special attention to the most prevalent preventable infectious disease. All the evidences will be graded according to The Infectious Diseases Society of America grading system.
Cooperation and conflict in romantic partners’ personal projects: the role of life domains
Authors: Rosta-Filep Orsolya , Sallay Viola , Carbonneau Noémie , Martos Tamás 
Published: March 2022

AbstractPersonal projects represent a person’s pursuits in different life domains. The present study examines the orientations of adults’ personal projects and how these orientations are embedded in the dynamics of romantic relationships. Cross-sectional data from 249 married or cohabitating Hungarian heterosexual couples were collected (mean age 42 ± 10.76 and 39.64 ± 10.21 years for male and female partners, respectively). An adapted version of the Personal Project Assessment procedure was completed by both partners individually. Four of their chosen projects were evaluated based on perceived cooperation and conflict regarding these projects and other predefined aspects. First, after applying a person-oriented approach, four meaningful content domains emerged from the thematically coded data using cluster analysis: (1) Practical, (2) Work-Life Balance, (3) Relationships, and (4) Learning and Growth orientations. For both genders, people with Learning and Growth orientation were younger than those with Practical orientation, and among women, the Work-Life Balance orientation group was older. Second, we linked the content domains to relationship experiences on the dyadic level. Both partners with Learning and Growth orientation goals perceived less cooperation. Female partners whose spouses had Work-Life Balance or Learning and Growth orientation goals perceived less conflict regarding their own goals. Overall, Learning and Growth-oriented goals can be considered more distant from the dynamics of romantic relationships because they involve fewer joint experiences and less cooperation and conflict.
Disentangling between- and within-person associations of psychological distress and mental well-being: An experience sampling study examining the dual continua model of mental health among university students
Authors: Kraiss Jannis T. , Kohlhoff Martje , ten Klooster Peter M. 
Published: March 2022

AbstractThe dual continua model assumes that psychological distress and mental well-being are two related, yet distinct dimensions of mental health. Previous studies did convincingly show the distinctiveness of these two dimensions using mainly cross-sectional research. Despite the importance to distinguish between- and within-person associations in psychological theories, to date, no study specifically distinguished between- and within-person associations for the relationship between distress and well-being. Therefore, the objective of this study was to validate whether the dual continua model actually holds when examined within individuals. Intensive longitudinal data were collected through experience sampling. The sample included 25 university students (mean age = 23.50 years, 56% female), who completed a baseline questionnaire as well as momentary measures of psychological distress and mental well-being three times per day for two weeks. 1,014 timepoints were analyzed using multilevel models and person-mean centering was applied to distinguish between- and within person associations. A significant moderate negative between-person association was found for the relationship between psychological distress and mental well-being (β = −.363, marginal R2 = 0.15, p < .001). The within-person association was also significant and similar in magnitude (β = −.432, marginal R2 = 0.18, p < .001) at the group level. Individual within-person associations between distress and well-being varied substantially, but were negative for almost all participants. This study is an important step towards validating the applicability and universality of this widely used model. The current findings provide preliminary evidence that the dual continua model does not only hold between people, but also on the level it is actually used for, namely within individual people.
Crabs Go With the Flow: Declining Conductivity and Cooler Temperatures Trigger Spawning Migrations for Female Giant Mud Crabs (Scylla serrata) in Subtropical Estuaries
Authors: Hewitt Daniel E. , Niella Yuri , Johnson Daniel D. , Suthers Iain M. , Taylor Matthew D. 
Published: March 2022

AbstractSpawning is a key life history event for aquatic species that can be triggered by environmental signals. For estuarine-dependent species, the timing of such triggers can be important for determining future patterns in recruitment. Here, we used acoustic telemetry to identify the potential drivers of spawning migration in female Giant Mud Crabs (Scylla serrata). Eighty-nine mature female crabs were tagged in two subtropical south-east Australian estuaries, the Clarence River (~ 29.4°S) and Kalang River (~ 30.5°S), during the summer spawning season (November–June) over two years (2018/19 and 2020/21), and their movements were monitored for up to 68 d, alongside high-resolution environmental data. Crabs were considered to have ‘successfully’ migrated if they were detected at the mouth of the estuary, a behaviour exhibited by 52% of tagged crabs. The highest probability of migration was associated with relatively low temperatures (< 22 °C) and when conductivity rapidly declined (< -10 mS cm−1d−1) following heavy rainfall. Furthermore, migration coincided with larger tides associated with the new and full moon, and following heavy rainfall, which may aid rapid downstream migration. Oceanic detections of 14 crabs (30% of ‘successful’ migrators) showed that once crabs left estuaries they migrated north. These patterns show that variability in environmental triggers for spawning migrations may contribute to interannual variation in spawning patterns, which may in turn impact fisheries productivity in this region.
The WOEST 2 registry
Authors: de Veer A. J. W. M. , Bennaghmouch N. , Bor W. L. , Herrman J. P. R. , Vrolix M. , Meuwissen M. , Vandendriessche T. , Adriaenssens T. , de Bruyne B. , Magro M. , Dewilde W. J. M , ten Berg J. M. 
Published: March 2022

AbstractBackgroundPatients on oral anticoagulants (OACs) undergoing percutaneous coronary intervention (PCI) also require aspirin and a P2Y12 inhibitor (triple therapy). However, triple therapy increases bleeding. The use of non-vitamin K antagonist oral anticoagulants (NOACs) and stronger P2Y12 inhibitors has increased. The aim of our study was to gain insight into antithrombotic management over time.MethodsA prospective cohort study of patients on OACs for atrial fibrillation or a mechanical heart valve undergoing PCI was performed. Thrombotic outcomes were myocardial infarction, stroke, target-vessel revascularisation and all-cause mortality. Bleeding outcome was any bleeding. We report the 30-day outcome.ResultsThe mean age of the 758 patients was 73.5 ± 8.2 years. The CHA2DS2-VASc score was ≥ 3 in 82% and the HAS-BLED score ≥ 3 in 44%. At discharge, 47% were on vitamin K antagonists (VKAs), 52% on NOACs, 43% on triple therapy and 54% on dual therapy. Treatment with a NOAC plus clopidogrel increased from 14% in 2014 to 67% in 2019. The rate of thrombotic (4.5% vs 2.0%,p = 0.06) and bleeding (17% vs. 14%,p = 0.42) events was not significantly different in patients on VKAs versus NOACs. Also, the rate of thrombotic (2.9% vs 3.4%,p = 0.83) and bleeding (18% vs 14%,p = 0.26) events did not differ significantly between patients on triple versus dual therapy.ConclusionsPatients on combined oral anticoagulation and antiplatelet therapy undergoing PCI are elderly and have both a high bleeding and ischaemic risk. Over time, a NOAC plus clopidogrel became the preferred treatment. The rate of thrombotic and bleeding events was not significantly different between patients on triple or dual therapy or between those on VKAs versus NOACs.