bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral neuropathy as a very rare symptom in a patient with Niemann–Pick type C with negative enzymatic evaluation: a case report
Authors: Barzegar Mohammad , Valaee Fatemeh , Ghoreishizadeh Shadi 
Published: January 2022

Abstract
Background
Niemann–Pick is a rare metabolic disease distinguished by lysosomal storage defects. This disease is characterized by sphingomyelinase acid deficiency, causing its accumulation in various organs such as the kidneys, spleen, liver, brain, and nerves. Niemann–Pick disease is categorized into four groups: A, B, C, and D. Peripheral neuropathy is an extremely rare complication in patients with Niemann–Pick type C, which certainly leads to neurologic deterioration.

Case presentation
We report a case of Niemann–Pick type C disease in a 3-year-old Iranian Azeri female patient who was hospitalized twice. The first time was at 1 month of age with symptoms of splenomegaly, jaundice, and elevated liver enzymes, and the second time was at around age 2 for loss of mental and physical abilities. The patient presented with failure to thrive. According to paraclinical examinations, mildly delayed myelination along with a nonspecific periventricular hypersignal intensity was seen. Interestingly, the patient’s Niemann–Pick type C enzymatic function was evaluated twice and was negative on both occasions, while she was positive for NPC1 and NPC2 gene examinations.

Conclusions
In this study, despite the enzymatic study being negative, Niemann–Pick type C disease was finally confirmed, revealing the importance of mutations in Niemann–Pick type C pathogenesis. Besides, peripheral neuropathy was diagnosed in this patient as a very rare symptom of Niemann–Pick type C.
Concurrent myasthenia gravis-related cervical thymoma in a patient with diffuse large B-cell lymphoma: a case report
Authors: Kunacheewa Chutima , Wongwiangjunt Sattawut , Sukpanichnant Sanya 
Published: January 2022

Abstract
Background
Cervical thymoma is a rare thymic epithelial neoplasm. Evidence supports an increased risk of second primary malignancies in patients with thymoma. We report a rare case of a patient with synchronous cervical thymoma and diffuse large B-cell lymphoma.

Case presentation
An 81-year-old Thai woman was referred for further treatment of diffuse large B-cell lymphoma at Siriraj Hospital, Bangkok, Thailand. While waiting for a review of the original pathological examination of a mass in the left neck and a mass in the left arm, the attending physician noticed ptosis of the upper eyelids, which was proven to be caused by myasthenia gravis. The final pathology review confirmed that the arm mass was diffuse large B-cell lymphoma, but the neck mass was cervical thymoma, type B1, not diffuse large B-cell lymphoma. Interestingly, the patient reported that the arm mass had been present for 2 years, while the neck mass had grown rapidly in the past month. A diagnostic challenge had arisen when the initial morphological evaluation was not performed with care, causing the first pathologist to misinterpret that the neoplastic cells in both masses were the same.

Conclusion
Concurrent cervical thymoma and diffuse large B-cell lymphoma were proven after a careful pathology review, leading to better clinical management.
Reduced reference image and video quality assessments: review of methods
Authors: Dost Shahi , Saud Faryal , Shabbir Maham , Khan Muhammad Gufran , Shahid Muhammad , Lovstrom Benny 
Published: January 2022

AbstractWith the growing demand for image and video-based applications, the requirements of consistent quality assessment metrics of image and video have increased. Different approaches have been proposed in the literature to estimate the perceptual quality of images and videos. These approaches can be divided into three main categories; full reference (FR), reduced reference (RR) and no-reference (NR). In RR methods, instead of providing the original image or video as a reference, we need to provide certain features (i.e., texture, edges, etc.) of the original image or video for quality assessment. During the last decade, RR-based quality assessment has been a popular research area for a variety of applications such as social media, online games, and video streaming. In this paper, we present review and classification of the latest research work on RR-based image and video quality assessment. We have also summarized different databases used in the field of 2D and 3D image and video quality assessment. This paper would be helpful for specialists and researchers to stay well-informed about recent progress of RR-based image and video quality assessment. The review and classification presented in this paper will also be useful to gain understanding of multimedia quality assessment and state-of-the-art approaches used for the analysis. In addition, it will help the reader select appropriate quality assessment methods and parameters for their respective applications.
Experimental Investigation on the Mechanical Properties of Polypropylene Hybrid Fiber-Reinforced Roller-Compacted Concrete Pavements
Authors: Liang Ninghui , You Xiufei , Yan Ru , Miao Qingxu , Liu Xinrong 
Published: January 2022

AbstractTo explore the effect of multi-scale polypropylene fiber (PPF) hybridization on the mechanical properties of roller-compacted concrete (RCC), the early-age (3, 7, 14, 28 days) compressive strength, splitting tensile strength and uniaxial tensile test of RCC reinforced with micro-, macro- and hybrid polypropylene fibers were investigated. Then, the tensile stress–strain curve of polypropylene fiber-reinforced roller-compacted concrete (PFRCC) and the corresponding tensile parameters were obtained. The uniaxial tensile constitutive equation of PFRCC and fiber hybrid effect function was also proposed. Finally, the enhancement mechanism of fiber hybridization on mechanical properties of RCC was analyzed. The results indicated that the strength and toughness of PFRCC improved with the incorporation of PPF, showing obvious plastic failure characteristics of PFRCC. Before curing the concrete for 7 days, micro-PPF played a major role in strengthening RCC, while macro-PPF played a major role in reinforcing concrete after that. Moreover, the tensile strength and toughness indexes of multi-scale PFRCC performed the best, indicating the positive hybridization of three types of PPF. The proposed PFRCC uniaxial tensile constitutive equation and fiber hybrid effect function based on existing researches were also well matched with the experimental results.
Multidetector CT findings of primary pleural angiosarcoma : a systematic review, an additional cases report
Authors: Gil Bo Mi , Chung Myung Hee , Lee Ki-Nam , Jung Jung Im , Yoo Won Jong , Kwon Soon Seog , Lee Heejeong 
Published: January 2022

Abstract
Background
To demonstrate and analyze the relatively common imaging findings in this rare primary pleural angiosarcoma (PPA).

Case presentation
Three cases of PPA, proven by video-assisted thoracic surgery biopsies are retrospectively reviewed. Patients were all male. Age ranges from 65 to 75 years old age (mean; 69). Major chief complaints were dyspnea and chest pain. One has a history of colon cancer, the other has a tuberculosis history and the other has no known history. Multidetector chest CT and PET CT were all done. Immunohistochemical studies were performed including CD31, CD34, or factor VIII-related antigen, vimentin, and cytokeratin. We also review the literatures on recently published PPA. All masses were from 1 to 10 cm. All three patients had multiple pleural based masses, which were ovoid in shape with relatively sharp margin in unilateral hemithorax. Multiple small circumscribed pleural masses are limited in the pleural space in two patients, whereas two, huge lobulated masses about up to 10 cm were present with pleural and extrapleural involvement in one patient. In two patients with pleural mass only, multiple pleural masses were only seen in parietal pleura in one patient and were in both visceral and parietal pleura in one patient. Pleural effusion were found in one side in one patient and in both sides in one patient. One angiosarcoma was arised from chronic tuberculotic pleurisy sequelae. All pleural masses are heterogenous with irregular internal low densities in all patients. Hematogenous metastases were found in liver, vertebra, rib in one patient, and were in lungs with mediastinal lymph node metastases in the other patient. Three patients survived for longer than 3months after diagnosis, but continued to deteriorate rapidly. Two patients underwent chemotherapy after surgical excision, and the other one with multiple metastases treated chemotherapy after CT-guided biopsy, but eventually all died. As a result of comparative analysis of a total of 13 patients’ images including 10 cases previously published, there was pleural effusion in all except 2 cases.

Conclusions
PPA were all necrotic without any vascularized enhancing nature, and manifested as unilateral circumscribed or localized pleural-based masses.
A study of composition and diversity variation of avifauna along with different types of agroforestry system in Kibet town, Southern Ethiopia
Authors: Yasin Hussen , Tekalign Wondimagegnehu 
Published: January 2022

Abstract
Background
Agroforestry is an integrated land-use system that plays a great role in the conservation of landscape biodiversity. The study aimed to assess the composition and diversity of avian species along with different habitat types of agroforestry in Kibet Town, Southern Ethiopia.

Methods
Four habitat types of agroforestry system which are home gardens, live fences, parkland, and eucalyptus woodlot were identified. Line transects were used for bird surveys. The Shannon diversity index (H′) and species evenness index (E) were used to compare diversity among habitat types. A similarity percentages (SIMPER) test was carried out to identify the main species and feeding guild that typified each habitat type. The overall significance was assessed with the ANOSIM test using PAST (version 4.03).

Results
A total of 50 bird species belonging to 28 families and 10 orders were recorded. Order Passeriformes (67.3%) had the highest number of species. Bird community composition differed among habitat types. The dissimilarity was mainly due to White-browed robin-chat (Cossypha heuglini), Streaky seed-eater (Serinus striolatus), Village Weaver (Ploceus cucullatus), African Paradise-Flycatcher (Terpsiphone viridis), and Black-Headed Paradise Flycatcher (T. rufiventer). The finding also revealed that insectivore was the dominant feeding guild.

Conclusions
The present study shows evidence that more insectivore bird species use different types of agroforestry as habitat and foraging sites. So, any concerned bodies who have engaged in avian conservation should give special consideration to this modified landscape.
Honey bee (Apis mellifera ligustica) acetylcholinesterase enzyme activity and aversive conditioning following aluminum trichloride exposure
Authors: Chicas-Mosier A. M. , Black T. E. , Hester K. P. , Belzunces L. P. , Abramson C. I. 
Published: January 2022

Abstract
Background
Aluminum is the third most prevalent element in the earth’s crust. In most conditions, it is tightly bound to form inaccessible compounds, however in low soil pH, the ionized form of aluminum can be taken up by plant roots and distributed throughout the plant tissue. Following this uptake, nectar and pollen concentrations in low soil pH regions can reach nearly 300 mg/kg. Inhibition of acetylcholinesterase (AChE) has been demonstrated following aluminum exposure in mammal and aquatic invertebrate species. In honey bees, behaviors consistent with AChE inhibition have been previously recorded; however, the physiological mechanism has not been tested, nor has aversive conditioning.

Results
This article presents results of ingested aqueous aluminum chloride exposure on AChE as well as acute exposure effects on aversive conditioning in an Apis mellifera ligustica hive. Contrary to previous findings, AChE activity significantly increased as compared to controls following exposure to 300 mg/L Al3+. In aversive conditioning studies, using an automated shuttlebox, there were time and dose-dependent effects on learning and reduced movement following 75 and 300 mg/L exposures.

Conclusions
These findings, in comparison to previous studies, suggest that aluminum toxicity in honey bees may depend on exposure period, subspecies, and study metrics. Further studies are encouraged at the moderate-high exposure concentrations as there may be multiple variables that affect toxicity which should be teased apart further.
DWI-related texture analysis for prostate cancer: differences in correlation with histological aggressiveness and data repeatability between peripheral and transition zones
Authors: Tsuruta Chie , Hirata Kenji , Kudo Kohsuke , Masumori Naoya , Hatakenaka Masamitsu 
Published: January 2022

Abstract
Background
We investigated the correlation between texture features extracted from apparent diffusion coefficient (ADC) maps or diffusion-weighted images (DWIs), and grade group (GG) in the prostate peripheral zone (PZ) and transition zone (TZ), and assessed reliability in repeated examinations.

Methods
Patients underwent 3-T pelvic magnetic resonance imaging (MRI) before radical prostatectomy with repeated DWI using b-values of 0, 100, 1,000, and 1,500 s/mm2. Region of interest (ROI) for cancer was assigned to the first and second DWI acquisition separately. Texture features of ROIs were extracted from comma-separated values (CSV) data of ADC maps generated from several sets of two b-value combinations and DWIs, and correlation with GG, discrimination ability between GG of 1–2 versus 3–5, and data repeatability were evaluated in PZ and TZ.

Results
Forty-four patients with 49 prostate cancers met the eligibility criteria. In PZ, ADC 10% and 25% based on ADC map of two b-value combinations of 100 and 1,500 s/mm2 and 10% based on ADC map with b-value of 0 and 1,500 s/mm2 showed significant correlation with GG, acceptable discrimination ability, and good repeatability. In TZ, higher-order texture feature of busyness extracted from ADC map of 100 and 1,500 s/mm2, and high gray-level run emphasis, short-run high gray-level emphasis, and high gray-level zone emphasis from DWI with b-value of 100 s/mm2 demonstrated significant correlation, excellent discrimination ability, but moderate repeatability.

Conclusions
Some DWI-related features showed significant correlation with GG, acceptable to excellent discrimination ability, and moderate to good data repeatability in prostate cancer, and differed between PZ and TZ.
Does grip strength correlate with rotator cuff strength in patients with atraumatic shoulder instability?
Authors: Turabi Ruqayyah , Horsely Ian , Birch Helen , Jaggi Anju 
Published: January 2022

Abstract
Aim
To investigate if there is a correlation between grip strength (GS) and rotator cuff (RC) strength in patients with atraumatic shoulder instability (ASI) and to compare the relationship between these two measures with that previously published for a healthy population. Moreover, to determine if testing GS could be incorporated as a surrogate clinical assessment for RC strength in these patients.

Methods
A total of 20 subjects with ASI were included. Out of the 20 patients, eight presented with bilateral instability, which constituted a total of 28 atraumatic unstable shoulders (N = 28). GS was measured using a Jamar hand-dynamometer. External rotation (ER) and internal rotation (IR) strength was tested in inner and outer ranges using a hand-held dynamometer (HHD). Pearson’s correlation test was computed to investigate the relationship. Multiple linear regression was conducted to predict GS based on RC strength.

Results
Significant and strong positive correlations were found between GS and inner-range IR (r = 0.764, P < 0.001), inner-range ER (r = 0.611, P = 0.001), outer-range IR (r = 0.817, P < 0.001), and outer-range ER (r = 0.736, P < 0.001). A significant regression equation was found (F (4, 23) = 13.254, P < 0.001), with an R2 of 0.697 indicating that RC strength explained 69.7% of the variance in GS.

Conclusions
The results support the hypothesis showing that GS is strongly associated with RC strength in ASI patients. The simplicity of handgrip testing allows it to be used in clinical scenarios where sophisticated assessment tools are not available. GS is a convenient means to monitor patient progress during shoulder rehabilitation programs.
Liquid-crystal metasurfaces: Self-assembly for versatile optical functionality
Authors: Kasyanova Irina V. , Gorkunov Maxim V. , Palto Serguei P. 
Published: January 2022

Abstract
Liquid crystals subjected to modulated surface alignment assemble into metasurface-type structures capable of various flat-optical functionalities, including light diffraction and focusing, deflection and splitting. Remaining in a fluid phase, they are susceptible to external stimuli, and, in particular, can be efficiently controled by low voltages. We overview the existing approaches to the design and fabrication of liquid-crystal metasurfaces, highlight their realized optical functions and discuss the applied potential in emerging photonic devices.
Made by cells for cells – extracellular vesicles as next-generation mainstream medicines
Authors: Phan Thanh Huyen , Kim Sally Yunsun , Rudge Christopher , Chrzanowski Wojciech 
Published: January 2022

ABSTRACT
Current medicine has only taken us so far in reducing disease and tissue damage. Extracellular vesicles (EVs), which are membranous nanostructures produced naturally by cells, have been hailed as a next-generation medicine. EVs deliver various biomolecules, including proteins, lipids and nucleic acids, which can influence the behaviour of specific target cells. Since EVs not only mirror composition of their parent cells but also modify the recipient cells, they can be used in three key areas of medicine: regenerative medicine, disease detection and drug delivery. In this Review, we discuss the transformational and translational progress witnessed in EV-based medicine to date, focusing on two key elements: the mechanisms by which EVs aid tissue repair (for example, skin and bone tissue regeneration) and the potential of EVs to detect diseases at an early stage with high sensitivity and specificity (for example, detection of glioblastoma). Furthermore, we describe the progress and results of clinical trials of EVs and demonstrate the benefits of EVs when compared with traditional medicine, including cell therapy in regenerative medicine and solid biopsy in disease detection. Finally, we present the challenges, opportunities and regulatory framework confronting the clinical application of EV-based products.
GABA receptors in the olfactory epithelium of the gilthead seabream (Sparus aurata)
Authors: Costa Rita A. , Velez Zélia , Hubbard Peter C. 
Published: January 2022

ABSTRACT
Exposure to high PCO2/low pH seawater induces behavioural alterations in fish; a possible explanation for this is a reversal of Cl−/HCO3− currents through GABAA receptors (the GABAA receptor theory). However, the main evidence for this is that gabazine, a GABAA receptor antagonist, reverses these effects when applied to the water, assuming that exposure to systems other than the CNS would be without effect. Here, we show the expression of both metabotropic and ionotropic GABA receptors, and the presence of GABAA receptor protein, in the olfactory epithelium of gilthead seabream. Furthermore, exposure of the olfactory epithelium to muscimol (a specific GABAA receptor agonist) increases or decreases the apparent olfactory sensitivity to some odorants. Thus, although the exact function of GABAA receptors in the olfactory epithelium is not yet clear, this may complicate the interpretation of studies wherein water-borne gabazine is used to reverse the effects of high CO2 levels on olfactory-driven behaviour in fish.
Resting costs too: the relative importance of active and resting energy expenditure in a sub-arctic seabird
Authors: Tremblay Fred , Whelan Shannon , Choy Emily S. , Hatch Scott A. , Elliott Kyle H. 
Published: January 2022

ABSTRACT
Breeding is costly for many animals, including birds that must deliver food to a central place (i.e. nest). Measuring energy expenditure throughout the breeding season can provide valuable insight into physiological limitations by highlighting periods of high demand, and ultimately allows improvement of conservation strategies. However, quantifying energy expenditure in wildlife can be challenging, as existing methods do not measure both active (e.g. foraging) and resting energy costs across short and long time scales. Here, we developed a novel method for comparing active and resting costs in 66 pre-breeding and breeding seabirds (black-legged kittiwakes, Rissa tridactyla) by combining accelerometry and triiodothyronine (T3) as proxies for active and resting costs, respectively. Active energy costs were higher during incubation (P=0.0004) and chick rearing (P&lt;0.0001) than during pre-laying, because of an increase in the time spent in flight of 11% (P=0.0005) and 15% (P&lt;0.0001), respectively. Levels of T3, reflecting resting costs, peaked marginally during incubation with a mean (±s.d.) concentration of 4.71±1.97 pg ml−1 in comparison to 2.66±1.30 pg ml−1 during pre-laying (P=0.05) and 3.16±2.85 pg ml−1 during chick rearing (P=0.11). Thus, although chick rearing is often assumed to be the costliest breeding stage by multiple studies, our results suggest that incubation could be more costly as a result of high resting costs. We highlight the importance of accounting for both active and resting costs when assessing energy expenditure.
Particle Adsorption on Polymer Gel Surface Driven by van der Waals Attraction
Authors: Aoyama Yurina , Sato Naoko , Toyotama Akiko , Okuzono Tohru , Yamanaka Junpei 
Published: January 2022

Abstract
Adsorption of particles on soft hydrogels, which plays an important role in various scientific and industrial fields, has often been studied using interactions such as hydrogen bonding. Here, we demonstrate that submicron-sized colloidal particles can be adsorbed onto gels, solely by van der Waals (vdW) attraction, without any special interaction. We investigated the adsorption of silica, polystyrene, and titania particles on polyacrylamide (PAAm) and polydimethylacrylamide (PDMA) hydrogels. The vdW force was tuned by the refractive index of media. Previously, we studied the particle adsorption on gels (N. Sato et al., Sci. Rep. 7(1), 2017) and concluded that the vdW force is a strong driving force. However, the influence of the medium viscosity on the adsorption rate and the contribution of interactions other than the vdW force needed to be clarified. The PDMA linear polymer adsorbed strongly on the silica particles, but the PAAm polymer did not. On the other hand, both PDMA and PAAm hydrogels strongly adsorbed silica and all other particles in water. The amount of adsorption varied with the magnitude of Hamaker constant. These results indicate that the vdW force is a sufficiently strong driving force for the particle adsorption to polymer hydrogel surfaces in water.