bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Oral Probiotics Supplementation in Overweight or Obese Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Li Zijun , Li Yanfei , Pan Bei , Wang Xiaoman , Wu Yu , Guo Ke , Yang Minyan , Ma Mina , Qiao Chengdong , Yang Kehu 
Published: November 2022

Abstract

Gut microbiota has been identified as a unique endocrine organ that linked to the development of cardiovascular disease and other illnesses that deteriorated in overweight or obese postmenopausal women. The object of this systematic review and meta-analysis was to assess the effects of the oral supplementation with probiotics for overweight or obese postmenopausal women. We made a systematic search for randomized controlled trials (RCTs) from published to April 2022 in MEDLINE, EMBASE, Cochrane library, Web of science and ClinicalTrials.gov. The risks of bias in individual studies was assessed with the Cochrane risk of bias tool for randomized trials (RoB 2.0). Two reviewers independently selected studies and collected data. There were 6 studies came from 5 RCTs included in this systematic review. Compared with placebo, probiotics supplementation group had reductions in insulin (MD -4.20 IU/L (95% CI -8.11 to -0.30 IU/L), I2 = 54%) and HOMA-IR (MD -1.25 (95% CI -2.49 to -0.01), I2 = 50%). It also showed the improvements in body adiposity, lipid profile and inflammation, but they were non-significant. In addition to body adiposity and cardiovascular risk markers, there was one trail showed administration of probiotics also had an effect on iron metabolism. In conclusion, probiotics have a potential beneficial for glucose metabolism in overweight or obese postmenopausal women, but the number of current studies is small, the results need to be interpreted with caution and explained by more studies in the future.
ResTr: A Joint Framework for Retinal Vein Occlusion Image Classification
Authors: Wang Xiaochen 
Published: November 2022

Abstract
The classification method based on convolutional neural network can improve the performance of the pattern recognition system by automatically extracting and self-learning features. At present, the conventional image classification network, including the network method designed in this paper, directly uses the common depth convolution network to directly extract and classify features. Therefore, the core of optimizing the experimental results is how to better extract the features in the image, that is, to extract more advanced and richer features. The advantage of Transformer is to capture the global context information in the way of attention, so as to establish a long-distance dependence on the target, so as to extract more powerful features.
Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls
Authors: Kruk Dennis , Yeung Anna , Faiz Alen , Hacken Nick H.T. ten , Timens Wim , Kuppevelt Toin H. , Daamen Willeke , Hof Danique , Harmsen Martin C. , Rojas Mauricio , Heijink Irene H. 
Published: November 2022

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental models of COPD, but differences between sources may impact on their potential use in therapeutic strategies in patients.
Aim:To assess the transcriptome of lung-derived MSCs (LMSCs), bone marrow-derived MSCs (BM-MSC) and adipose-derived MSCs (AD-MSCs) from COPD patients and non-COPD controls.
Methods: We studied differences in gene expression profiles between the MSC-subtypes, as well as between COPD and control using RNA sequencing (RNA-seq).
Results: We show that besides heterogeneity between donors, MSCs from different sources have strongly divergent gene signatures. The growth factors FGF10 and HGF were predominantly expressed in LMSCs. MSCs from all sources displayed altered expression profiles in COPD, with most pronounced significantly up- and downregulated genes in MSCs from adipose tissue. Pathway analysis revealed that the most differentially expressed genes in COPD-derived AD-MSCs are involved in extracellular matrix (ECM) binding and expression. In LMSCs, the gene that differed most strongly between COPD and control was CSGALNACT1, an ECM modulating gene.
Conclusion:Autologous MSCs from COPD patients display abnormalities with respect to their transcriptome, which were surprisingly most profound in MSCs from extrapulmonary sources. LMSCs may be optimally equipped for lung tissue repair because of the expression of specific growth factor genes.
Severe COVID-19 caused by persistent SARS-CoV-2 infection successfully treated with dual direct acting antivirals.
Authors: Snell Luke Blagdon , Bakrania Prijay , Williams Tom G S , Tam Jerry C H , Fontoura Dayana Da Silva , Shaw Emily , Daunt Anna , Edgeworth Jonathan D , Hemsley Carolyn J , Fields Paul , Agarwal Sangita , Lams Boris , Cahill Helen , Milligan Iain , Botgros Alina , Nebbia Gaia , Douthwaite Sam T , Aarons Emma 
Published: November 2022

Abstract

We report the successful use of combination therapy with two direct acting antivirals for treatment of chronic COVID-19. An immunocompromised 60 year old male with persistent SARS-CoV-2 infection over 4 months had chronic, progressive COVID-19 requiring mechanical ventilation. After failing monotherapy with two antivirals and neutralising monoclonal antibodies, he was treated with a 10 day course of intravenous remdesivir and crushed nirmatrelvir/ritonavir (Paxlovid) administered through a nasogastric tube. Following treatment, SARS-CoV-2 RNA became undetectable, with resolution of supplemental oxygen requirement and acute inflammatory changes on computed tomography. This case demonstrates potential synergy between remdesivir and nirmatrelvir/ritonavir in treating persistent, symptomatic SARS-CoV-2 infection.
Evaluation of Salivary KCNJ3 mRNA Levels in Breast Cancer: A Case–control Study and in silico Analysis
Authors: Koopaie Maryam , Jomehpoor Mahsa , Manifar Soheila , Mousavi Reza , Kolahdooz Sajad 
Published: November 2022

Background:
Breast cancer (BC) is considered the most malignant and central cancer-related death among women worldwide. There is an essential need to discover new methods for developing noninvasive and low-cost diagnoses. The present study examines the expression of KCNJ3 which acts as a biomarker for detecting BC in the saliva of BC patients compared to controls.

Methods:
The mRNA expression level of KCNJ3 has been evaluated. Forty-three unstimulated whole saliva samples from BC patients and forty-three salivary samples from healthy controls were collected. The mRNA level was measured using quantitative real-time polymerase chain reaction (qRT-PCR). Furthermore, the protein-protein interaction network in which KCNJ3 is involved was obtained. In silico analysis was applied to predict the possible molecular mechanisms of KCNJ3 in BC development.

Results:
Differentially expressed KCNJ3 was statistically significant between BC patients and controls (p<0.001). The sensitivity and specificity of KCNJ3 mRNA in BC detection were 76.74% and 94.95%, respectively. Receiver operating characteristic (ROC) curve analysis of KCNJ3 mRNA revealed that Area under the curve (AUC) was 0.923 (95% Confidence Interval (CI): 0.866-0.979). AUCs of ROC curve analysis were 0.743 (95% CI: 0.536-0.951), 0.685 (95% CI: 0.445-0.925), and 0.583(95% CI: 0.343-0.823) for differentiation stage I from stage III, stage I to stage II and finally stage II from stage III, respectively. Furthermore, the GABAergic synapse signaling pathway was suggested as a potential pathway involved in BC development.

Conclusion:
Salivary levels of KCNJ3 could be considered a potential diagnostic biomarker with high sensitivity and specificity for BC detection.
Effectiveness of Mouthwash-Containing Silver Nanoparticles on Cariogenic Microorganisms, Plaque Index, and Salivary pH in A Group of Saudi Children
Authors: Maher Yahia A. , Fathi Adel , Sembawa Bassam A , Elkhyat Sameeh H. , Hafiz Habib F. , Marghalani Abdullah A. 
Published: November 2022

Objectives:To compare the effectiveness of Silver nanoparticles (AgNPs) and Chlorhexidine (CHX) mouthwash onStreptococcus mutans (S. mutans),Lactobacillus spp., andCandida albicans(C. albicans) counts O’Leary plaque index (O’Leary PI) scores, and salivary pH levels among children.Materials and Methods:The study sample consisted of 117 eligible participants aged 12–18 years. They were divided into control, CHX, and AgNPs groups, with 39 subjects per group. The log10salivary microbial counts, O’Leary PI, and salivary pH values were recorded and statistically analyzed at baseline and the 28thday. Descriptive statistics were presented as the mean ± standard deviation. In addition, the analyses of variance (ANOVA) and Tukey posthoc test were implemented. Thep-value ≤ 0.05 denotes a significant difference between the two points.Results:AgNPs and CHX mouthwash were found to have significantly reduced salivary microbial counts and O’Leary PI scores. The salivary pH levels notably increased on the 28thday (p-value < 0.001). All measured outcomes demonstrated notable effects, with the greatest observed for the CHX group, followed by the AgNPs group, and finally, the control group.Conclusion:Chlorhexidine and AgNPs mouthwash effectively reduced the cariogenic microbial count and dental plaque and improved the salivary pH values. AgNPs mouthwash may be used as an adjunctive measure to prevent dental caries.
Importance of Patient Involvement in Creating Content for eHealth Interventions: Qualitative Case Report in Orthopedics
Authors: Timmers Thomas , van der Weegen Walter , Janssen Loes , Kremer Jan , Kool Rudolf Bertijn 
Published: November 2022

Background
In many industries, collaboration with end users is a standard practice when developing or improving a product or service. This process aims for a much better understanding of who the end user is and how the product or service could be of added value to them. Although patient (end user) involvement in the development of eHealth apps is increasing, this involvement has mainly focused on the design, functionalities, usability, and readability of its content thus far. Although this is very important, it does not ensure that the content provided aligns with patients’ priorities.

Objective
In this study, we aimed to explore the added value of patient involvement in developing the content for an eHealth app. By comparing the findings from this study with the existing app, we aimed to identify the additional informational needs of patients. In addition, we aimed to help improve the content of apps that are already available for patients with knee replacements, including the app our group studied in 2019.

Methods
Patients from a large Dutch orthopedic clinic participated in semistructured one-on-one interviews and a focus group session. All the patients had undergone knee replacement surgery in the months before the interviews, had used the app, and were therefore capable of discussing what information they missed or wished for before and after the surgery. The output was inductively organized into larger themes and an overview of suggestions for improvement.

Results
The interviews and focus group session with 11 patients identified 6 major themes and 30 suggestions for improvement, ranging from information for better management of expectations to various practical needs during each stage of the treatment. The outcomes were discussed with the medical staff for learning purposes and properly translated into an improved version of the app’s content.

Conclusions
In this study, patients identified many suggestions for improvement, demonstrating the added value of involving patients when creating the content of eHealth interventions. In addition, our study demonstrates that a relatively small group of patients can contribute to improving an app’s content from the patient’s perspective. Given the growing emphasis on patients’ self-management, it is crucial that the information they receive is not only relevant from a health care provider’s perspective but also aligns with what really matters to patients.

Trial Registration
Netherlands Trial Register NL8295; https://trialsearch.who.int/Trial2.aspx?TrialID=NL8295
RANCANGAN PENATAAN ARSIP KARYA SENI PERTUNJUKAN UNTUK MENDUKUNG PENGEMBANGAN TRIDHARMA PERGURUAN TINGGI DI ISI SURAKARTA
Authors: Widyasih Wahyu 
Published: November 2022

This study aims to identify the types of art archives and arrange their arrangement designs in order to support the development of the tridharma of higher education at the Indonesian Institute of the Arts (ISI) Surakarta. The archives studied are the archives of performing arts that are the result of the Tridharma organization. The research was conducted using a qualitative descriptive method. That is describing a situation based on the facts that appear. The results of field observations show that the performing arts document consists of text, audio, and video. Its creation cannot be separated from previous works of art as a reference or source of works of art. Artwork documents are archives because they are the result of the tridharma process, but have only been managed as a library. The archives are dominated by final works of art from study programs at the Faculty of Performing Arts, results of artistic research from the Research Centre, and results of community service works of art from the Centre for Community Service. ISI Surakarta Archives Retention Schedule stipulates the archive as a static archive (permanent) after the retention period expires. Its arrangement requires a design according to archival standards. The design is made by taking into account the principle of provenance and original order. The design includes archive creators, archive classification (final project reports, research, and community service), archive indexes (reports, audio visual recordings, and intellectual property certificates), archive cross-linking to link different types of archives for the same archive, information archives, access conditions and archive service procedures. Keywords: archive, arrangement, design, performing arts, tridharma
Optimal Frequency of Urinary Albumin Screening in Type 1 Diabetes
Authors: Perkins Bruce A. , Bebu Ionut , H. de Boer Ian , Molitch Mark E. , Zinman Bernard , Bantle John , Lorenzi Gayle M. , M. Nathan David , Lachin John M. 
Published: November 2022

<p> </p>
<p><strong>Background.</strong> Kidney disease screening recommendations include annual urine testing for albuminuria after five years duration of type 1 diabetes. We aimed to determine a simple, risk factor-based screening schedule that optimizes early detection and testing frequency.</p>
<p><strong>Methods.</strong> Urinary albumin excretion measurements from 1343 participants in the Diabetes Control and Complications Trial and its long-term follow-up were used to create piecewise-exponential incidence models assuming 6-month constant hazards. Likelihood of the onset of moderately or severely elevated albuminuria (confirmed albumin excretion rate AER ≥30 or ≥300 mg/24h, respectively) and its risk factors were used to identify individualized screening schedules. Time with undetected albuminuria and number of tests were compared to annual screening.</p>
<p><strong>Results. </strong>The three-year cumulative incidence of elevated albuminuria following normoalbuminuria at any time during study was 3.2%, which was strongly associated with higher glycated hemoglobin (HbA1c) and AER. Personalized screening in 2 years for those with current AER ≤10 mg/24h and HbA1c ≤8% (“Low-Risk”, 0.6% 3-year cumulative incidence), in 6 months for those with AER 21-30 mg/24h or HbA1c ≥9% (“High-Risk”, 8.9% 3-year cumulative incidence), and 1 year for all others (“Average-Risk”, 2.4% 3-year cumulative incidence) was associated with 34.9% reduction in time with undetected albuminuria and 20.4% reduction testing frequency as compared to annual screening. Stratification by categories of HbA1c or AER alone were associated with reductions of lesser magnitude.</p>
<p><strong>Conclusions. </strong>A personalized alternative to annual screening in type 1 diabetes can substantially reduce both the time with undetected kidney disease and the frequency of urine testing.</p>
Kuis Interaktif Menggunakan Aplikasi Classpoint pada Materi Indahnya Keragaman di Negeriku untuk Siswa Kelas IV Sekolah Dasar
Authors: Kurniawan Nico Dwi , Ika Yatri  
Published: November 2022

Menghadapi tantangan yang besar pada era revolusi industri 4.0 ini, pendidikan dituntut untuk menyesuaikan, termasuk pendidikan pada jenjang dasar maupun menengah. Tantangan pendidikan pada revolusi industri 4.0 ini khususnya di Indonesia, salah satunya adalah masifnya media yang sesuai dengan tuntutan perkembangan zaman. Untuk itu, pendidik harus menguasai teknologi agar dapat menyesuaikan dengan peserta didik. Penelitian pengembangan ini bertujuan untuk menciptakan kuis interaktif menggunakan aplikasi classpoint pada pokok materi indahnya keragaman di negeriku kelas IV, menguji kelayakan kuis interaktif, dan melihat respon siswa terhadap kuis interaktif. Penelitian ini menerapkan model 4-D melalui 4 tahapan yaitu Define, Design, Development, dan Disseminate. Instrumen penelitian untuk mendapatan data berupa angket penilaian ahli materi, ahli media, dan angket respon siswa terhadap kuis interaktif. Hasil yang diperoleh dari penelitian ini yaitu menciptakan kuis interaktif menggunakan aplikasi classpoint pada pokok materi indahnya keragaman di negeriku. Berdasarkan hasil penilaian ahli dinyatakan bahwa kuis interaktif sangat layak. Hal ini berdasarkan rata-rata dari data secara keseluruhan tim ahli materi yaitu 93,7% mendapat kategori " sangat layak", tim ahli media yaitu 98% mendapat kategori "sangat layak," dan berdasarkan respon siswa mendapatkan hasil sebesar 82.89% mendapat kategori “sangat layak”. Melihat hasil yang diperoleh dapat disimpulkan bahwa kuis interaktif layak digunakan sebagai media bagi guru dan siswa dalam melakukan kegiatan evaluasi pembelajaran. Implikasi penelitian ini yaitu meningkatkan motivasi dan antusias siswa dalam mengerjakan kuis serta menambah wawasan guru dan peneliti.
Seperti Apa Permasalahan Pembelajaran Biologi pada Siswa SMA?
Authors: Azizah Nurul , Alberida Heffi 
Published: November 2022

Permasalahan dalam pembelajaran dapat mengganggu tercapainya tujuan pembelajaran, sehingga dibutuhkan identifikasi sebagai langkah awal sebelum dilakukan tindak lanjut berupa pencegahan dan pemberian solusi untuk setiap permasalahan yang ada. Tujuan dari penelitian ini yakni untuk mengidentifikasi apa saja permasalahan pembelajaran biologi yang dihadapi siswa khususnya pada materi Archaebacteria dan Eubacteria. Penelitian ini merupakan penelitian deskriptif dengan metode kualitatif. Subjek yang terlibat dalam penelitian ini yakni guru dan siswa kelas X SMA. Pengumpulan data dalam penelitian dilakukan dengan metode observasi dan wawancara. Analisis data hasil penelitian dilakukan dengan analisis deskriptif kualitatif dalam bentuk deskripsi berdasarkan temuan penelitian. Hasil penelitian menunjukkan bahwa terdapat empat permasalahan utama yang dialami oleh siswa kelas X dalam pembelajaran biologi, diantaranya adalah siswa mengalami kesulitan memahami materi biologi, kurangnya fokus dan konsentrasi belajar siswa, adanya ketidaksesuaian pemahaman konsep dan jenis tes evaluasi yang digunakan guru. Berdasarkan hasil tersebut dapat disimpulkan bahwa masih terdapat banyak kendala yang dialami oleh siswa dalam pembelajaran biologi, sehingga hal tersebut membutuhkan perhatian kusus guna meningkatkan hasil belajar serta kualitas belajar siswa.
PLATINUM RECOVERY FROM USED AUTO CATALYSTS: DISSOLUTION AND PRECIPITATION STUDIES
Authors: KASZA Angela M. , KATONA Gabriel , DAN Monica , VOICA Cezara , GRAD Oana , MIHEȚ Maria , DEZSO Tibor , NAGY Ruben , BOTS Tihamer , LAZǍR Mihaela Diana 
Published: November 2022

Noble metals are used in a plethora of applications, from electronic and communication equipments, to aerospacial engines, mobile phones and catalytic convertors. Currently, there is a continuous interest in the recovery of noble metals from waste, as their natural reserves are limited. Herein, the paper presents studies on the recovery of platinum from spent automotive catalysts. The process involves two steps - dissolving of platinum, followed by its precipitation into a hexacloroplatinum complex. The optimum reaction conditions for dissolving Pt from the spent automotive catalyst use a mixture of H2O2 + HCl (1:5.5 molar ratio) at 30°C, for 8 h. For the full recovery of platinum from the solution, the volumetric ratio of 4:1 between the platinum solution and the precipitating ammonium chloride solution is optimum. In addition, studies regarding the precipitation time and temperature have also been performed. All the obtained precipitates were analyzed by X-ray powder diffraction and showed the structure of the hexachloroplatinic (NH4)2[PtCl6] complex, with high purity. Upscaling of the processes for technological transfer show promising results in the recovery of platinum from spent automotive catalysts.
May bananas go extinct? The epidemic of Panama disease. A review
Authors: Waraczewski Robert , Sołowiej Bartosz G. 
Published: November 2022

Bananas are one of most popular fruits worldwide. Estimated export in 2020 reached a record high of 22.2 million tons, a 1.7% growth compared to 2019. They are cultivated in Asia, Africa, Australia, Latin, and South America. People value them for their taste, easy accessibility, low price, plenty of nutrients and vitamins, preparation versatility. They contain vitamins A, C, E, K and from B group, fibre, magnesium, phosphorus, calcium, and potassium. In some countries bananas and plantains are the basis of diet and are consumed daily, like rice or potatoes. Unfortunately, these wonderful fruits may soon cease to exist. An illness called Panama disease caused by Fusarium oxysporum fungus is responsible for destroying 950,000 metric tonnes of crop yields annually. Previous variant of that disease almost caused a total wipeout of former mostly cultivated banana cultivar Gros Michel. In this work Panama disease history, biology, and preventionare reviewed.
The influence of biological preparations Azofix and Maxprolin and nitrogen fertilisation on soil mineral nitrogen content in growing season and after spring wheat harvest
Authors: Płaza Anna , Rzążewska Emilia 
Published: November 2022

The objective of the research reported here was to determine the effect of Azofix and Maxprolin against nitrogen fertiliser on mineral nitrogen content in the soil during the period of intensive growth of spring wheat plants and after its harvest. The following two factors were chosen: I. Biological products: control, Azofix, Maxprolin, Azofix + Maxprolin; II. Nitrogen fertilisation: non-fertilised control, 60 kg N ha–1, 90 kg N ha–1, 90 kg N ha–1 + foliar fertilisation. During the period of intensive growth of spring wheat plants and after harvesting, mineral nitrogen content in the soil was determined. The research demonstrated that, during the period of their intensive growth, spring wheat plants had access to the largest amount of mineral nitrogen in the topsoil following treatment with Azofix + Maxprolin and an application of the nitrogen rate of 90 kg N ha–1.