bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketone Monoester Ingestion Alters Metabolism and Simulated Rugby Performance in Professional Players
Authors: Peacock Oliver J. , Gonzalez Javier T. , Roberts Simon P. , Smith Alan , Drawer Scott , Stokes Keith A. 
Published: April 2022

Ketone ingestion can alter metabolism but effects on exercise performance are unclear, particularly with regard to the impact on intermittent-intensity exercise and team-sport performance. Nine professional male rugby union players each completed two trials in a double-blind, randomized, crossover design. Participants ingested either 90 ± 9 g carbohydrate (CHO; 9% solution) or an energy matched solution containing 20 ± 2 g CHO (3% solution) and 590 mg/kg body mass β-hydroxybutyrate monoester (CHO + BHB-ME) before and during a simulated rugby union-specific match-play protocol, including repeated high-intensity, sprint and power-based performance tests. Mean time to complete the sustained high-intensity performance tests was reduced by 0.33 ± 0.41 s (2.1%) with CHO + BHB-ME (15.53 ± 0.52 s) compared with CHO (15.86 ± 0.80 s) placebo (p = .04). Mean time to complete the sprint and power-based performance tests were not different between trials. CHO + BHB-ME resulted in blood BHB concentrations that remained >2 mmol/L during exercise (p < .001). Serum lactate and glycerol concentrations were lower after CHO + BHB-ME than CHO (p < .05). Coingestion of a BHB-ME with CHO can alter fuel metabolism (attenuate circulating lactate and glycerol concentrations) and may improve high-intensity running performance during a simulated rugby match-play protocol, without improving shorter duration sprint and power-based efforts.
Phase Equilibriums of Ammonium Chloride Systems as Model Hydrogenolysis Products of Organochlorine Compounds under Naphtha Hydrotreating Conditions
Authors: Korenev V. V. , Tomin V. P. , Zhdaneev O. V. , Kapustin V. M. 
Published: April 2022

Abstract
The study focuses on corrosion challenges for naphtha hydrotreating equipment (installed upstream of a reforming unit) caused by ammonium chloride deposits and on the development of adequate chemical engineering protection measures. Using an experimental setup, we investigated the sublimation/desublimation of ammonium chloride at varying pressures and temperatures in a medium typical of naphtha and hydrogen-bearing gas streams flowing from a naphtha hydrotreater. Superstoichiometric concentrations of hydrogen chloride were found to significantly decrease the desublimation temperature (by 30–50°C) compared to a system that has a stoichiometric HCl concentration. Consequently, solid-phase ammonium chloride exists in a wider range of temperatures and pressures. Introducing surfactants (especially higher alcohols) into the system reduces adhesion and affects the crystalline structure of salt deposits—despite the solid phase being stabilized by an excess (superstoichiometric) concentration of hydrogen chloride—which makes surfactants suitable for mitigating the salt deposition challenge. Based on the data obtained, we proposed effective chemical engineering protection methods that use water-soluble corrosion inhibitors in combination with an online automated system for organochlorine control.
Long-term outcomes of transsclerally sutured intraocular lens correctly fixed in the ciliary sulcus
Authors: Sugiura Takeshi , Sakimoto Tohru , Tanaka Yoshikazu , Inoue Yasushi , Oshika Tetsuro 
Published: April 2022

ObjectiveTo report the long-term postoperative outcomes of transsclerally sutured intraocular lenses (IOLs), in which the haptics were correctly fixated into the ciliary sulcus using an auxiliary device and endoscope.Methods and analysisData were collected from eyes that were followed up for at least 12 months after ciliary sulcus suture fixation of an IOL using an auxiliary device for securely placing the IOL haptics to the ciliary sulcus, which was confirmed using intraoperative endoscopy in all cases. The corrected distance visual acuity (CDVA), refractive error, anterior chamber depth (ACD), IOL decentration and tilt, corneal endothelial cell density (CECD) and postoperative complications were recorded. ACD and IOL deviations were compared with those of normal controls after standard cataract surgery.ResultsA total of 146 eyes of 142 patients were included, with a mean follow-up period of 56.0±35.3 (range 12–174) months. Postoperative CDVA from 1 month to 8 years and final CDVA were significantly better, and the mean refraction error, ACD and CECD decline rate were −0.71±0.75 dioptre, 4.01±0.37 mm and −7.4%±16.0%, respectively. Compared with normal controls, ACD was not significantly different but the tilt and decentration were significantly different. The main postoperative complications included vitreous haemorrhage (24.0％), suture thread exposure (19.2%) and corectopia (18.5%). There were no cases of IOL dislocation due to suture breakage or postoperative endophthalmitisConclusionLong-term postoperative outcomes were favorable with good CDVA and without IOL dislocation and endophthalmitis. The significance and value of fixing haptics to the ciliary sulcus should be re-evaluated.
Language-parametric static semantic code completion
Authors: Pelsmaeker Daniel A. A. , van Antwerpen Hendrik , Poulsen Casper Bach , Visser Eelco 
Published: April 2022

Code completion is an editor service in IDEs that proposes code fragments for the user to insert at the caret position in their code. Code completion should be sound and complete. It should be sound, such that it only proposes fragments that do not violate the syntactic and static semantic rules of the language. It should be complete, such that it proposes all valid fragments so that code completion can be used to construct all programs. To realize soundness and completeness, code completion should be informed by the language definition. In practice, the implementation of code completion is an additional effort in the implementation of a language.
In this paper, we develop a framework for language-parametric semantic code completion for statically typed programming languages based on their specification of syntax and static semantics, realizing the implementation of a code completion editor service with minimal additional effort. The framework builds on the SDF3 syntax definition formalism and the Statix static semantics specification language. The algorithm reinterprets the static semantics definition to find sound expansions of predicates and solutions to name resolution queries in scope graphs. This allows a search strategy to explore the solution space and synthesize completion proposals. The implementation of the strategy language and code completion algorithm extend the implementation of the Statix solver, and can be used for any language defined in Statix. We demonstrate soundness and completeness of the completion proposal synthesis, and evaluate its performance.
Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study
Authors: Subbiah Vivek , Braña Irene , Longhi Alessandra , Boni Valentina , Delord Jean-Pierre , Awada Ahmad , Boudou-Rouquette Pascaline , Sarantopoulos John , Shapiro Geoffrey I. , Elias Anthony , Ratan Ravin , Fernandez Cristian , Kahatt Carmen , Cullell-Young Martin , Siguero Mariano , Zeaiter Ali , Chawla Sant P. 
Published: April 2022

Abstract

Purpose:
Lurbinectedin suppresses the oncogenic transcription factor EWS-FLI1 through relocalization to the nucleolus, and delays tumor growth in mice bearing Ewing sarcoma xenografts. On the basis of this rationale, lurbinectedin was evaluated in patients with relapsed Ewing sarcoma.

Patients and Methods:
This open-label, single-arm, Basket phase II trial included a cohort of 28 treated adult patients with confirmed Ewing sarcoma, measurable disease as per Response Evaluation Criteria In Solid Tumors (RECIST) v.1.1, Eastern Cooperative Oncology Group performance status ≤2, adequate organ function, no central nervous system metastasis, and pretreated with ≤2 chemotherapy lines for metastatic/recurrent disease. Patients received lurbinectedin 3.2 mg/m2 as a 1-hour infusion every 3 weeks. Primary endpoint was overall response rate (ORR) as per RECIST v.1.1. Secondary endpoints included time-to-event parameters and safety profile.

Results:
ORR was 14.3% [95% confidence interval (CI), 4.0%–32.7%], with median duration of response of 4.2 months (95% CI, 2.9–5.5 months). Median progression-free survival was 2.7 months (95% CI, 1.4–4.3 months), clinical benefit rate was 39.3%, and disease control rate was 57.1%. With 39% censoring, median overall survival was 12.0 months (95% CI, 8.5–18.5 months). Most common grade 3/4 adverse events were neutropenia (57%), anemia, thrombocytopenia, and treatment-related febrile neutropenia (14% each). No deaths or discontinuations were due to toxicity.

Conclusions:
Lurbinectedin was active in the treatment of relapsed Ewing sarcoma and had a manageable safety profile. Lurbinectedin could represent a valuable addition to therapies for Ewing sarcoma, and is currently being evaluated in combination with irinotecan in advanced Ewing sarcoma in a phase Ib/II trial.
Description of a new species of Eurysthea Thomson (Coleoptera, Cerambycidae, Cerambycinae)
Authors: Santos-Silva Antonio , Heffern Daniel , Botero Juan Pablo 
Published: April 2022

Eurysthea vandenberghei, new species from Nicaragua is described, and E. vandenberghei Santos-Silva, Heffern & Botero, 2021 is considered a nomen nudum.
Should I stay or should I go: escape behaviour of Russell’s vipers, Daboia russelii (Shaw & Nodder, 1797) in India’s agricultural landscapes
Authors: Cyriac Vivek P. , Srinivasa Kiran B. , Kumar Lohith , Martin Gerard 
Published: April 2022

Abstract
Predation exerts a strong selective force on prey, and hence prey species have evolved a multitude of ways to escape predation. One strategy by which many mobile species escape predation is by fleeing when approached by predators. However, fleeing too early can have fitness costs. Thus, optimal escape theory suggests that escape behaviour in prey depends on the risk of being eaten and the fleeing costs. Several studies on mammals, birds and lizards lend support to this hypothesis. However, few studies have explored escape behaviour in snakes. Here, using radio telemetry to track snakes in the field, we study the escape behaviour in Russell’s vipers, a highly venomous and cryptic snake, responsible for the highest number of snakebite deaths in India. We show that escape response, i.e., the decision to stay or flee, was influenced by intrinsic factors such as the snake’s behaviour and body temperature. We also show that the flight initiation distance, the distance at which the snake flees, was mostly determined by habitat selection, i.e., the visibility of the snake and the distance to the nearest cover. Overall, we show that different factors could determine the decision to flee and when to flee. We also highlight how understanding escape response in such highly venomous, medically important yet secretive snakes could potentially help reduce human-snake encounters and mitigate the snakebite crisis.
Still Trust? Some Reflections Over the New EU-UK Arrest Warrant
Authors: Grossio Lorenzo 
Published: April 2022

Abstract
This article discusses whether a recognition mechanism based on a relationship of trust sustains surrender under the EU-UK tca. Having framed the main features of the new judicial cooperation arrangements, the article firstly shows that the EU-UK Arrest Warrant entails a brand-new form of recognition of custodial decisions, labelled as recognition à la carte. Secondly, the article underlines that this form of recognition is grounded on a specific relationship of trust, different from the one governing the afsj, framed as mutual core trust. Finally, the paper discusses the enhanced role of the ECtHR in reviewing the application of the EU-UK Arrest Warrant, thus illustrating why ecj case-law concerning the eaw system could play a major role in shaping the Strasbourg Court’s reasoning.
Conceptualizing Political Illiberalism: A Long Overdue Index of Illiberal Political Values
Authors: Borja Anthony Lawrence A. 
Published: April 2022

Abstract
There is an urgent need to study illiberal political values. However, current efforts have focused on democratic values, democratic support, populist attitudes, and authoritarian values. Consequently, they have missed something older and more fundamental, namely, political illiberalism. Hence, I pave the way for future inquiries by proposing and validating a composite measure built upon a reverse engineering of political illiberalism from existing works on illiberal democracy, political intolerance, and the normative philosophy of political liberalism. Through quantitative psycho-political analysis (i.e., factor analysis, internal reliability tests, and basic descriptive statistics), I posit and dissect an index responding to the limits of existing ones. Overall, I define illiberal political values as a value system constituted by intolerant and leader-centric values tied with anti-institutionalist tendencies.
Responding to Debunking Arguments
Authors: Van Eyghen Hans 
Published: April 2022

Abstract
In this response article, I argue that Launonen’s criticisms either are beyond the scope of my argument in chapter 5 of Arguing from Cognitive Science of Religion or wrongfully presume that evolutionary explanations exhaustively explain religious beliefs. I also criticize Launonen’s claim that arguments in terms of divine design are preferable to arguments in terms of truth-tracking cognitive mechanisms.
The Deterioration of Cervical Kyphosis During Neck Flexion after Laminoplasty Affects the Surgical Outcome of Cervical Spondylotic Myelopathy
Authors: Funaba Masahiro , Imajo Yasuaki , Suzuki Hidenori , Nishida Norihiro , Sakamoto Takuya , Sakai Takashi 
Published: April 2022

Study Design A retrospective single-center study. Objective The present study investigated whether postoperative cervical alignment changes, in addition to preoperative patient backgrounds, imaging parameters, and disease severity, affect outcomes 1 year after laminoplasty. Methods One hundred and three cervical spondylotic myelopathy (CSM) patients who underwent laminoplasty were enrolled. Preoperative and postoperative (1-year) Japanese Orthopedic Association (JOA) scores, cervical alignment, and balance on X-rays were assessed. Patients were classified into 2 groups for a univariate analysis according to the status of the recovery rate (RR) of the JOA score ≥50%. A multiple logistic regression analysis was performed to identify factors associated with good surgical outcomes a. Results The mean RR of the JOA score was 47.5% and the loss of cervical lordosis in the neutral position was 5.5°. The univariate analysis revealed slight differences in age, sex, and the duration of disease. Preoperative C2-7 angles were not significantly different. The C2-7 angle during flexion after surgery was significantly smaller in Group F. In the multiple logistic regression analysis, significant factors associated with the status of RR≥50% were a younger age (OR: .75, 95%CI: .59–.96), shorter duration of disease (OR: .94, 95%CI: .89–.99), and a lordotic C2-7 angle during neck flexion after surgery (OR: 1.47, 95%CI: 1.1–1.95). Conclusion We retrospectively assessed the surgical outcomes of laminoplasty in 103 CSM cases. In addition to an older age and longer duration of disease, postoperative deteriorations in cervical kyphosis during neck flexion had a negative impact on outcomes.
Is Indirect Decompression and Fusion More Effective than Direct Decompression and Fusion for Treating Degenerative Lumbar Spinal Stenosis With Instability? A Systematic Review and meta-Analysis
Authors: Gagliardi Martin J. , Guiroy Alfredo J. , Camino-Willhuber Gaston , Joaquim Andrei F. , Carazzo Charles A. , Yasuda Ezequiel , Cabrera Juan P. , Morales Ciancio Alejandro R. 
Published: April 2022

Study design: Systematic Review and Meta-analysis. Objective: Surgical alternatives to treat lumbar spinal stenosis and instability include indirect (ALIF, OLIF, and LLIF) and direct (TLIF or posterior lumbar interbody fusion) decompression and fusion interventions. Although both approaches have proven to be effective in reducing symptoms, it is unknown if there is any difference in effectiveness between them. In this systematic review and meta-analysis, we aimed to evaluate postoperative pain and disability in patients treated whit indirect vs direct decompression and fusion approaches. Methods: We conducted a systematic review of the literature consulting several databases and identified studies that enrolled patients diagnosed with degenerative lumbar spinal stenosis and instability treated with indirect or direct decompression and fusion techniques. Our primary endpoints were the visual analogue scale, Oswestry Disability Index, and the Japanese Orthopedics Association Back Pain Evaluation Questionnaire 1 year after the procedure. Secondary outcomes included complication rate, blood loss, and surgical time. Results: Nine retrospective and comparative studies were included enrolling a total of 1004 participants. Both surgical strategies had satisfactory clinical outcomes with no significant difference at 1 year. Although the complication rate was similar for both groups, the profile of the adverse events was different. In addition, patients treated with indirect decompression and fusion had significantly less blood loss and operative times. Conclusions: Indirect and direct decompression and fusion techniques are similarly effective in treating patients with lumbar spinal stenosis and instability. The ID group had significantly lower intraoperative blood loss and surgical time values.
Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications
Authors: Döhner Hartmut , Weber Daniela , Krzykalla Julia , Fiedler Walter , Wulf Gerald , Salih Helmut , Lübbert Michael , Kühn Michael W. M. , Schroeder Thomas , Salwender Hans , Götze Katharina , Westermann Jörg , Fransecky Lars , Mayer Karin , Hertenstein Bernd , Ringhoffer Mark , Tischler Hans-Joachim , Machherndl-Spandl Sigrid , Schrade Anika , Paschka Peter , Gaidzik Verena I. , Theis Frauke , Thol Felicitas , Heuser Michael , Schlenk Richard F. , Bullinger Lars , Saadati Maral , Benner Axel , Larson Richard , Stone Richard , Döhner Konstanze , Ganser Arnold 
Published: April 2022

Abstract
We conducted a single-arm, phase 2 trial (German-Austrian Acute Myeloid Leukemia Study Group [AMLSG] 16-10) to evaluate midostaurin with intensive chemotherapy followed by allogeneic hematopoietic-cell transplantation (HCT) and a 1-year midosta urin maintenance therapy in adult patients with acute myeloid leukemia (AML) and fms-related tyrosine kinase 3 (FLT3) internal tandem duplication (ITD). Patients 18 to 70 years of age with newly diagnosed FLT3-ITD-positive AML were eligible. Primary and key secondary endpoints were event-free survival (EFS) and overall survival (OS). Results were compared with a historical cohort of 415 patients treated on 5 prior AMLSG trials; statistical analysis was performed using a double-robust adjustment with propensity score weighting and covariate adjustment. Results were also compared with patients (18-59 years) treated on the placebo arm of the Cancer and Leukemia Group B (CALGB) 10603/RATIFY trial. The trial accrued 440 patients (18-60 years, n = 312; 61-70 years, n = 128). In multivariate analysis, EFS was significantly in favor of patients treated within the AMLSG 16-10 trial compared with the AMLSG control (hazard ratio [HR], 0.55; P &lt; .001); both in younger (HR, 0.59; P &lt; .001) and older patients (HR, 0.42; P &lt; .001). Multivariate analysis also showed a significant beneficial effect on OS compared with the AMLSG control (HR, 0.57; P &lt; .001) as well as to the CALGB 10603/RATIFY trial (HR, 0.71; P = .005). The treatment effect of midostaurin remained significant in sensitivity analysis including allogeneic HCT as a time-dependent covariate. Addition of midostaurin to chemotherapy was safe in younger and older patients. In comparison with historical controls, the addition of midostaurin to intensive therapy led to a significant improvement in outcome in younger and older patients with AML and FLT3-ITD. This trial is registered at clinicaltrialsregistry.eu as Eudra-CT number 2011-003168-63 and at clinicaltrials.gov as NCT01477606.
The duration of chronic low back pain is associated with acute postoperative pain intensity in lumbar fusion surgery: a prospective observational study
Authors: Qian Mei-ping , Dong Mei-rong , Li Juan , Kang Fang 
Published: April 2022

Abstract
Background
Pre-existing chronic pain has been associated with severe postoperative pain. In this study, we sought to prospectively analyse the association between the duration of chronic low back pain and the intensity of acute postoperative pain after lumbar fusion surgery.

Methods
A total of 330 patients who underwent lumbar fusion surgery were divided into three groups (chronic low back pain less than 1 year, one to 5 years, and more than 5 years) based on the duration of chronic pain. On the first postoperative day, the maximum pain scores of each patient were recorded during the day and at night. Bivariate correlation and logistic regression were performed to identify relationships between acute postoperative pain and related variables (age, sex, smoking history, body mass index, operation history, duration of surgery, level of preoperative pain, aetiology of back pain, Self-rating Anxiety Scale, Self-rating Depression Scale, FRAIL scale, and duration of chronic low back pain). If the postoperative pain score was > 3 when the patient reported was at rest, the patients were treated with postoperative intravenous self-controlled analgesia or rescue analgesics if necessary.

Results
There was an association between severe acute postoperative pain and the duration of chronic low back pain. In terms of VAS day, multivariable logistic regression showed the duration of chronic low back pain was not statistically significant (OR = 2.48, 95% CI: 0.900 to 6.828, p = 0.0789). The result is uncertain because the confidence interval included the null after controlling for SAS, SDS, BMI, and aetiology of back pain. In terms of VAS night, patients with a duration of chronic low back pain of more than 5 years were more likely having moderate to severe acute postoperative pain (VAS > 3) compared to patients with a duration of chronic low back pain less than 1 year (OR = 3.546, 95% CI: 1.405 to 8.95, p = 0.0074). Hospital stay, the pain score on the day of discharge and the pain score after 3 months displayed no significant difference among the three groups (P > 0.05). However, the need for postoperative rescue analgesics was different among the three groups (P < 0.05).

Conclusion
The longer the duration of chronic pain was, the higher the incidence of moderate to severe acute postoperative pain was and the greater the amount of analgesics required after surgery.

Trial registration
This study was registered at the Chinese Clinical Trial Registration Center (http://www.chictr.org.cn/index.aspx, clinical trial number: ChiECRCT20200165, date of registration: July 6, 2020).