bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Spasial Persebaran Infrastruktur Perdesaan Terhadap Produk Unggulan Kawasan Perdesaan Di Kecamatan Dangia
Authors: Saranani Muh.  Syawal , Rahim Manat , Geo La Ode 
Published: January 2022

Produk unggulan desa perlu ditingkatkan untuk kesejahteraan masyarakat. Tujuan dari penelitian ini yaitu menganalisis persebaran Prukades (Produk Unggulan Kawasan Perdesaan) pada program Dana Desa di Kecamatan Dangi; dan untuk menganalisis dampak pengembangan Produk Unggulan Kawasan Perdesaan (Prukades) dengan adanya pembangunan infrastruktur desa di Kecamatan Dangia. Metode yang digunakan yaitu analisis kualitatif dan analisis kualitatif. Hasil penelitian ini yaitu Produksi Unggulan Desa (Prudes) rata-rata tahun 2015-2019 di Kecamatan Dangia tersebar di semua desa. Dampak dari Prukades yaitu dengan adanya infrastruktur desa memberikan dampak positif pada Prukades. Di Kecamatan Dangia mempunyai hasil produksi padi sawah hanya mencapai 1 - 5 ton per desa sebelum adanya infrastruktur desa, setelah adanya infrastruktur desa maka produksi pertanian di Kecamatan Dangia antara tahun 2015 sampai tahu 2019 padi sawah mencapai 146.000 ton. Komuditas Kakao mencapai 10 - 50 kg sebelum adanya infrastruktur desa, setalah adanya infrastruktur desa maka produksi kakao mencapai 488.000 kg. Komuditas lain yang mengalami kenaikan produksi setelah adanya infrastruktur desa. Kata Kunci: Dampak, Desa, Infrastruktur, Sebaran,
Analisis Ketersediaan Air Baku Pada Pdam Tirta Anoa Di Kota Kendari
Authors: Adiyanto Adiyanto , Ramli Muhammad , Syaf Hasbullah 
Published: January 2022

The provision of clean water to meet the needs of the community is something important, and the availability of clean water must be considered in order to meet the needs of the community, especially in Kendari City. This study aims to analyze the availability of raw water at the Regional Water Company (PDAM) Tirta Anoa Kendari City. The method used is the method of raw water availability by using discharge data from the Pohara River and the Wanggu River in 2010-2019. The results of this study are the availability of raw clean water at PDAM Kendari City is the production discharge of 300 ltr/second, the production discharge of Matabondu Springs of 50 l/second, the production discharge of the Wanggu River of 20 l/second, and the Anduonohu spring discharge of 5 ltr. /sec and Anggoeya at 40 liters/sec Keywords: raw water, availability, PDAMPenyedian air bersih untuk memenuhi kebutuhan masyarakat merupakan sesuatu yang penting, dan ketersediaan air bersih harus diperhatikan agar dapat memenuhi kebutuhan masyarakat, khususnya di Kota Kendari. Penelitian ini bertujuan untuk menganalisis ketersediaan air baku pada Perusahaan Daerah Air Minum (PDAM) Tirta Anoa Kota Kendari. Metode yang digunakan yaitu metode ketersediaan air baku dengan menggunakan data debit Sungai Pohara dan Sungai Wanggu tahun 2010-2019. Hasil Penelitian ini yaitu ketersediaan air bersih baku pada PDAM Kota Kendari adalah debit produksi sebesar 300 ltr/detik, debit produksi Mata Air Matabondu sebesar 50 l/detik, debit produksi Sungai Wanggu sebesar 20 l/detik, dan debit Mata air Anduonohu sebesar 5 ltr/dtk dan Anggoeya sebesar 40 liter/dtk Kata Kunci : Air Baku, Ketersediaan, PDAM
Manajemen Dan Tingkat Partisipasi Masyarakat Dalam Pengelolaan Sampah Di Kecamatan Puuwatu
Authors: Algiffari M.  Fauzhan , Rianse Usman , Sidu Dasmin 
Published: January 2022

The waste problem needs handling, and the community is part of the handling of this problem. This study aims to 1) explain the form and level of community participation in waste management in Puuwatu District, Kendari City, and 2) to find a waste management strategy in Puuwatu District. The analysis techniques used were SWOT and litmus test. The results showed, 1) The largest form of community participation was in the form of money (42%), with a low level of community participation. 2). The strategic issue in community-based integrated waste management is increasing the capacity of human resources in an effort to change people's perceptions, attitudes and behavior in waste management.Keywords: Management, Participation, Waste Management Masalah persampahan butuh penanganan dan masyarakat menjadi bagian dari penanganan permasalahan ini. Penelitian ini bertujuan untuk 1) menjelaskan bentuk dan tingkat partisipasi terhadap masyarakat dalam pengelolaan persampahan di Kecamatan Puuwatu Kota Kendari, dan 2) menemukan strategi yang ada pada pengelolaan sampah di Kecamatan Puuwatu. Teknik analasis yang digunakan yaitu SWOT dan uji litmus. Hasil penelitian menunjukkan, 1) Bentuk partisipasi masyarakat terbesar yaitu dalam bentuk uang(42 %), dengan tingkat partisipasi masyarakat yang masih rendah. 2). isu strategis dalam pengelolaan sampah terpadu berbasis masyarakat adalah meningkatkan kapasitas sumber daya manusia dalam upaya mengubah persepsi, sikap, dan prilaku masyarakat dalam pengelolaan sampah.Kata Kunci : Manajemen, Partispasi, Pengelolaan Sampah
Single-Cell Transcriptomes Combining with Consecutive Genomics Reveal Clonal Evolution and Gene Regulatory Networks in Relapsed and Refractory Multiple Myeloma
Authors: Xu Jiadai , Wang Yue , Wei Zheng , Zhuang Jingli , Li Jing , Sun Yifeng , Ren Liang , Wang Yawen , Li Panpan , Gu Shiyang , Zhang Yian , Jiang Jifeng , Chen Chen , Zhang Yu , Liu Peng 
Published: January 2022

This study attempted to investigate how clonal structure evolves, along with potential regulatory networks, as a result of multiline therapies in relapsed/refractory multiple myeloma (RRMM). Eight whole exome sequencing (WES) and one single cell RNA sequencing (scRNA-seq) were performed in order to assess dynamic genomic changes in temporal consecutive samples of one RRMM patient from the time of diagnosis to death (about 37 months). The 63-year-old female patient who suffered from MM (P1) had disease progression (PD) nine times from July 2017 [newly diagnosed (ND)] to Aug 2020 (death), and the force to drive branching-pattern evolution of malignant PCs was found to be sustained. The mutant-allele tumor heterogeneity (MATH) and tumor mutation burden (TMB) initially exhibited a downward trend, which was then upward throughout the course of the disease. Various somatic single nucleotide variants (SNVs) that had disappeared after the previous treatment were observed to reappear in later stages. Chromosomal instability (CIN) and homologous recombination deficiency (HRD) scores were observed to be increased during periods of all progression, especially in the period of extramedullary plasmacytoma. Finally, in combination with WES and scRNA-seq of P1-PD9 (the nineth PD), the intro-heterogeneity and gene regulatory networks of MM cells were deciphered. As verified by the overall survival of MM patients in the MMRF CoMMpass and GSE24080 datasets, RUNX3 was identified as a potential driver for RRMM.
Impact of Sepsis on High-Density Lipoprotein Metabolism
Authors: Reisinger Alexander C. , Schuller Max , Sourij Harald , Stadler Julia T. , Hackl Gerald , Eller Philipp , Marsche Gunther 
Published: January 2022

Background: High-density lipoproteins (HDL) are thought to play a protective role in sepsis through several mechanisms, such as promotion of steroid synthesis, clearing bacterial toxins, protection of the endothelial barrier, and antioxidant/inflammatory activities. However, HDL levels decline rapidly during sepsis, but the contributing mechanisms are poorly understood.Methods/Aim: In the present study, we investigated enzymes involved in lipoprotein metabolism in sepsis and non-sepsis patients admitted to the intensive care unit (ICU).Results: In 53 ICU sepsis and 25 ICU non-sepsis patients, we observed significant differences in several enzymes involved in lipoprotein metabolism. Lecithin-cholesterol acyl transferase (LCAT) activity, LCAT concentration, and cholesteryl transfer protein (CETP) activity were significantly lower, whereas phospholipid transfer activity protein (PLTP) and endothelial lipase (EL) were significantly higher in sepsis patients compared to non-sepsis patients. In addition, serum amyloid A (SAA) levels were increased 10-fold in sepsis patients compared with non-sepsis patients. Furthermore, we found that LCAT activity was significantly associated with ICU and 28-day mortality whereas SAA levels, representing a strong inflammatory marker, did not associate with mortality outcomes.Conclusion: We provide novel data on the rapid and robust changes in HDL metabolism during sepsis. Our results clearly highlight the critical role of specific metabolic pathways and enzymes in sepsis pathophysiology that may lead to novel therapeutics.
One-Pot Synthesized Amorphous Cobalt Sulfide With Enhanced Electrochemical Performance as Anodes for Lithium-Ion Batteries
Authors: Ren Long-Long , Wang Lin-Hui , Qin Yu-Feng , Li Qiang 
Published: January 2022

In order to solve the poor cycle stability and the pulverization of cobalt sulfides electrodes, a series of amorphous and crystalline cobalt sulfides were prepared by one-pot solvothermal synthesis through controlling the reaction temperatures. Compared to the crystalline cobalt sulfide electrodes, the amorphous cobalt sulfide electrodes exhibited superior electrochemical performance. The high initial discharge and charge capacities of 2,132 mAh/g and 1,443 mAh/g at 200 mA/g were obtained. The reversible capacity was 1,245 mAh/g after 200 cycles, which is much higher than the theoretical capacity. The specific capability was 815 mAh/g at 800 mA/g and increased to 1,047 mAh/g when back to 100 mA/g, indicating the excellent rate capability. The outstanding electrochemical performance of the amorphous cobalt sulfide electrodes could result from the unique characteristics of more defects, isotropic nature, and the absence of grain boundaries for amorphous nanostructures, indicating the potential application of amorphous cobalt sulfide as anodes for lithium-ion batteries.
Network-Like Platinum Nanosheets Enabled by a Calorific-Effect-Induced-Fusion Strategy for Enhanced Catalytic Hydrogenation Performance
Authors: Chen Ting-Wen , Pang Da-Wei , Kang Jian-Xin , Zhang Dong-Feng , Guo Lin 
Published: January 2022

In this paper, we report the construction of network-like platinum (Pt) nanosheets based on Pt/reduced graphite oxide (Pt/rGO) hybrids by delicately utilizing a calorific-effect-induced-fusion strategy. The tiny Pt species first catalyzed the H2-O2 combination reaction. The released heat triggered the combustion of the rGO substrate under the assistance of the Pt species catalysis, which induced the fusion of the tiny Pt species into a network-like nanosheet structure. The loading amount and dispersity of Pt on rGO are found to be crucial for the successful construction of network-like Pt nanosheets. The as-prepared products present excellent catalytic hydrogenation activity and superior stability towards unsaturated bonds such as olefins and nitrobenzene. The styrene can be completely converted into phenylethane within 60 min. The turnover frequency (TOF) value of network-like Pt nanosheets is as high as 158.14 h−1, which is three times higher than that of the home-made Pt nanoparticles and among the highest value of the support-free bimetallic catalysts ever reported under similar conditions. Furthermore, the well dispersibility and excellent aggregation resistance of the network-like structure endows the catalyst with excellent recyclability. The decline of conversion could be hardly identified after five times recycling experiments.
Salivary Microbial Dysbiosis Is Associated With Peri-Implantitis: A Case-Control Study in a Brazilian Population
Authors: Pallos Debora , Sousa Vanessa , Feres Magda , Retamal-Valdes Belen , Chen Tsute , Curtis Mike , Boaventura Richardson Mondego , Tanaka Marcia Hiromi , Salomão Gustavo Vargas da Silva , Zanella Louise , Tozetto-Mendoza Tania Regina , Schwab Gabriela , Franco Lucas Augusto Moyses , Sabino Ester Cerdeira , Braz-Silva Paulo Henrique , Shibli Jamil Awad 
Published: January 2022

Background and ObjectivesThe aim of this study was to examine the salivary microbiome in healthy peri-implant sites and those with peri-implantitis.MethodsSaliva samples were collected from 21 participants with healthy peri-implant sites and 21 participants with peri-implantitis. The V4 hypervariable region of the 16S rRNA gene was sequenced using the Ion Torrent PGM System (Ion 318™ Chip v2 400). The NGS analysis and composition of the salivary microbiome were determined by taxonomy assignment. Downstream bioinformatic analyses were performed in QIIME (v 1.9.1).ResultsClinical differences according to peri-implant condition status were found. Alpha diversity metrics revealed that the bacterial communities of participants with healthy peri-implant sites tended to have a richer microbial composition than individuals with peri-implantitis. In terms of beta diversity, bleeding on probing (BoP) may influence the microbial diversity. However, no clear partitioning was noted between the salivary microbiome of volunteers with healthy peri-implant sites or volunteers with peri-implantitis. The highest relative abundance of Stenotrophomonas, Enterococcus and Leuconostoc genus, and Faecalibacterium prausnitzii, Haemophilus parainfluenzae, Prevotella copri, Bacteroides vulgatus, and Bacteroides stercoris bacterial species was found in participants with peri-implantitis when compared with those with healthy peri-implant sites.ConclusionDifferences in salivary microbiome composition were observed between patients with healthy peri-implant sites and those with peri-implantitis. BoP could affect the diversity (beta diversity) of the salivary microbiome.
Frequent Constriction-Like Echocardiographic Findings in Elite Athletes Following Mild COVID-19: A Propensity Score-Matched Analysis
Authors: Lakatos Bálint Károly , Tokodi Márton , Fábián Alexandra , Ladányi Zsuzsanna , Vágó Hajnalka , Szabó Liliána , Sydó Nóra , Csulak Emese , Kiss Orsolya , Babity Máté , Kiss Anna Réka , Gregor Zsófia , Szűcs Andrea , Merkely Béla , Kovács Attila 
Published: January 2022

Background: The cardiovascular effects of SARS-CoV-2 in elite athletes are still a matter of debate. Accordingly, we sought to perform a comprehensive echocardiographic characterization of post-COVID athletes by comparing them to a non-COVID athlete cohort.Methods: 107 elite athletes with COVID-19 were prospectively enrolled (P-CA; 23 ± 6 years, 23% female) 107 healthy athletes were selected as a control group using propensity score matching (N-CA). All athletes underwent 2D and 3D echocardiography. Left (LV) and right ventricular (RV) end-diastolic volumes (EDVi) and ejection fractions (EF) were quantified. To characterize LV longitudinal deformation, 2D global longitudinal strain (GLS) and the ratio of free wall vs. septal longitudinal strain (FWLS/SLS) were also measured. To describe septal flattening (SF—frequently seen in P-CA), LV eccentricity index (EI) was calculated.Results: P-CA and N-CA athletes had comparable LV and RVEDVi (P-CA vs. N-CA; 77 ± 12 vs. 78 ± 13mL/m2; 79 ± 16 vs. 80 ± 14mL/m2). P-CA had significantly higher LVEF (58 ± 4 vs. 56 ± 4%, p &lt; 0.001), while LVGLS values did not differ between P-CA and N-CA (−19.0 ± 1.9 vs. −18.8 ± 2.2%). EI was significantly higher in P-CA (1.13 ± 0.16 vs. 1.01 ± 0.05, p &lt; 0.001), which was attributable to a distinct subgroup of P-CA with a prominent SF (n = 35, 33%), further provoked by inspiration. In this subgroup, the EI was markedly higher compared to the rest of the P-CA (1.29 ± 0.15 vs. 1.04 ± 0.08, p &lt; 0.001), LVEDVi was also significantly higher (80 ± 14 vs. 75 ± 11 mL/m2, p &lt; 0.001), while RVEDVi did not differ (82 ± 16 vs. 78 ± 15mL/m2). Moreover, the FWLS/SLS ratio was significantly lower in the SF subgroup (91.7 ± 8.6 vs. 97.3 ± 8.2, p &lt; 0.01). P-CA with SF experienced symptoms less frequently (1.4 ± 1.3 vs. 2.1 ± 1.5 symptom during the infection, p = 0.01).Conclusions: Elite athletes following COVID-19 showed distinct morphological and functional cardiac changes compared to a propensity score-matched control athlete group. These results are mainly driven by a subgroup, which presented with some echocardiographic features characteristic of constrictive pericarditis.
Isolated Diastolic Hypertension and Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis of Cohort Studies With 489,814 Participants
Authors: Huang Mingyan , Long Linzi , Tan Ling , Shen Aling , Deng Mi , Peng Yuxuan , Yang Wenwen , Li Hongzheng , Wei Yue , Li Meng , Liao Feifei , Liu Chao , Lu Aimei , Qu Hua , Fu Changgeng , Chen Keji 
Published: January 2022

Background:The association between isolated diastolic hypertension (IDH) and cardiovascular events has been inconsistently reported. This meta-analysis of cohort studies was designed to investigate the effect of the 2018 European Society of Cardiology (ESC) definition of IDH on the risk of composite cardiovascular events, cardiovascular mortality, all-cause mortality, and all strokes including ischemic stroke (IS) and hemorrhagic stroke (HS).Methods:PubMed, Embase, the Cochrane Library, and Web of Science were searched from inception to July 6, 2021. Cohort studies that investigated the association between IDH and cardiovascular events risk, compared to normotension, were included. Pooled hazard ratios (HRs) and 95% CIs were calculated using a random-effects models and heterogeneity was evaluated usingQ-test andI2statistic. The robustness of the associations was identified using sensitivity analysis. The methodological quality of the studies was assessed using the Newcastle–Ottawa scale. Publication bias was assessed using funnel plot, trim-and-fill method, Begg's test, and Egger's test.Results:A total of 15 cohort studies (13 articles) including 489,814 participants were included in this meta-analysis. The follow-up period ranged from 4.3 to 29 years. IDH was significantly associated with an increased risk of composite cardiovascular events (HR 1.28, 95% CI: 1.07–1.52,p= 0.006), cardiovascular mortality (HR 1.45, 95% CI: 1.07–1.95,p= 0.015), all strokes (HR 1.44, 95% CI: 1.04–2.01,p= 0.03), and HS (HR 1.64, 95% CI: 1.18–2.29,p= 0.164), but not associated with all-cause mortality (HR 1.20, 95% CI: 0.97–1.47,p= 0.087) and IS (HR 1.56, 95% CI: 0.87–2.81,p= 0.137). Subgroup analysis further indicated that IDH in the younger patients (mean age ≤ 55 years) and from Asia were significantly associated with an increased risk of composite cardiovascular events, while the elderly patients (mean age ≥ 55 years), Americans, and Europeans were not significantly associated with an increased risk of composite cardiovascular events.Conclusion:This meta-analysis provides evidence that IDH defined using the 2018 ESC criterion is significantly associated with an increased risk of composite cardiovascular events, cardiovascular mortality, all strokes and HS, but not significantly associated with all-cause death and IS. These findings also emphasize the importance for patients with IDH to have their blood pressure within normal, especially in the young adults and Asians.Trial Registration:PROSPERO, Identifier: CRD42021254108.
Origin and Pathways of Dissolved Organic Carbon in a Small Catchment in the Lena River Delta
Authors: Stolpmann Lydia , Mollenhauer Gesine , Morgenstern Anne , Hammes Jens S. , Boike Julia , Overduin Pier Paul , Grosse Guido 
Published: January 2022

The Arctic is rich in aquatic systems and experiences rapid warming due to climate change. The accelerated warming causes permafrost thaw and the mobilization of organic carbon. When dissolved organic carbon is mobilized, this DOC can be transported to aquatic systems and degraded in the water bodies and further downstream. Here, we analyze the influence of different landscape components on DOC concentrations and export in a small (6.45 km2) stream catchment in the Lena River Delta. The catchment includes lakes and ponds, with the flow path from Pleistocene yedoma deposits across Holocene non-yedoma deposits to the river outlet. In addition to DOC concentrations, we use radiocarbon dating of DOC as well as stable oxygen and hydrogen isotopes (δ18O and δD) to assess the origin of DOC. We find significantly higher DOC concentrations in the Pleistocene yedoma area of the catchment compared to the Holocene non-yedoma area with medians of 5 and 4.5 mg L−1 (p &lt; 0.05), respectively. When yedoma thaw streams with high DOC concentration reach a large yedoma thermokarst lake, we observe an abrupt decrease in DOC concentration, which we attribute to dilution and lake processes such as mineralization. The DOC ages in the large thermokarst lake (between 3,428 and 3,637 14C y BP) can be attributed to a mixing of mobilized old yedoma and Holocene carbon. Further downstream after the large thermokarst lake, we find progressively younger DOC ages in the stream water to its mouth, paired with decreasing DOC concentrations. This process could result from dilution with leaching water from Holocene deposits and/or emission of ancient yedoma carbon to the atmosphere. Our study shows that thermokarst lakes and ponds may act as DOC filters, predominantly by diluting incoming waters of higher DOC concentrations or by re-mineralizing DOC to CO2 and CH4. Nevertheless, our results also confirm that the small catchment still contributes DOC on the order of 1.2 kg km−2 per day from a permafrost landscape with ice-rich yedoma deposits to the Lena River.
Mining Hazards to the Safety of Segment Lining for Tunnel Boring Machine Inclined Tunnels
Authors: Zhuo Hui , Xie Dan , Sun Jinglai , Shi Xiaomeng 
Published: January 2022

The segment lining is a new type of support structure for mining tunnels. The disturbance of coal excavation leads to the deformation of segment lining and has great hazards to the safety of the tunnels. Based on the tunnel boring machine (TBM) inclined tunnels in Xinjie mine, the ultimate span L0 of the rock beam on the top slab of the coal seam was calculated according to the bending (tension) damage theory. A numerical model was built to simulate the bottom area of the inclined tunnels. During the coal mining, the additional displacements and additional stresses of the segment lining were analyzed, and then the safety factors of the support structure were calculated. Finally, the width of the coal pillar to protect the inclined tunnels was determined. The results showed that the ultimate span of the rock beam on the top of the coal seam is 31.7 m, the deformation of the inclined tunnel has a fish-belly shape, and the deformation leads to the increase of maximum axial force and bending moment. For the inclined tunnels in Xinjie coalmine, a total width of 91.3 m of coal pillar must be reserved to keep the safety factor of the structure higher than 2.0 and prevent the inclined tunnels from the mining hazards.