bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic fault identification in WSN‐based smart grid environment
Authors: Mullur Nagaraja Murthy Rekha , Mahadevaswamy Udigala Basavaraju 
Published: September 2022

SummaryWireless sensor network (WSN) plays a vital role in the smart grid (SG) environment. Due to the fault tolerance characteristics, cost reduction, and large‐scale convergence, SG introduces many unique challenges caused by system and functional devices. To solve this problem, a WSN‐based SG network is used to identify faults. During data transmission, faulty nodes occur in the transmission line. The node failures, calibration, network failures, low battery, dead nodes, environmental changes, software failures, and so on lead to the interruption in data delivery and spoil the entire WSN‐based SG network. In order to tackle these problems, the new WSN model is designed to detect the faults in the transmission line based on the SG environment. This paper uses the Adaptive Zigbee‐Aquila communication protocol (AZACP) to find the optimal shortest path for transferring data. AZACP finds the shortest optimal path for transmitting the sensed data to the base station with low cost and less time consumption. Fault detection automatically identifies the fault in the transmission line and isolates the faulty nodes to ensure efficient data transmission in WSN. Here, enhanced recurrent equilibrium neural network (ERENN) is introduced to identify the fault in data transmission. The proposed approach provides better performance in terms of evaluating performance metrics like throughput, delay, reliability, average residual energy, number of total transmissions, network lifetime, efficiency, and bit error rate (BER).
Recent insights into gap junction biogenesis in the cochlea
Authors: Defourny Jean , Thiry Marc 
Published: September 2022

AbstractIn the cochlea, connexin 26 (Cx26) and connexin 30 (Cx30) co‐assemble into two types of homomeric and heteromeric gap junctions between adjacent non‐sensory epithelial cells. These channels provide a mechanical coupling between connected cells, and their activity is critical to maintain cochlear homeostasis. Many of the mutations in GJB2 or GJB6, which encode Cx26 and Cx30 in humans, impair the formation of membrane channels and cause autosomal syndromic and non‐syndromic hearing loss. Thus, deciphering the connexin trafficking pathways in situ should represent a major step forward in understanding the pathogenic significance of many of these mutations. A growing body of evidence now suggests that Cx26/Cx30 heteromeric and Cx30 homomeric channels display distinct assembly mechanisms. Here, we review the most recent advances that have been made toward unraveling the biogenesis and stability of these gap junctions in the cochlea.
Response of distribution patterns of two closely related species in Taxus genus to climate change since last inter‐glacial
Authors: Wu Xingtong , Wang Minqiu , Li Xinyu , Yan Yadan , Dai Minjun , Xie Wanyu , Zhou Xiaofen , Zhang Donglin , Wen Yafeng 
Published: September 2022

AbstractClimate change affects the species spatio‐temporal distribution deeply. However, how climate affects the spatio‐temporal distribution pattern of related species on the large scale remains largely unclear. Here, we selected two closely related species in Taxus genus Taxus chinensis and Taxus mairei to explore their distribution pattern. Four environmental variables were employed to simulate the distribution patterns using the optimized Maxent model. The results showed that the highly suitable area of T. chinensis and T. mairei in current period was 1.616 × 105 km2 and 3.093 × 105 km2, respectively. The distribution area of T. chinensis was smaller than that of T. mairei in different periods. Comparison of different periods shown that the distribution area of the two species was almost in stasis from LIG to the future periods. Temperature and precipitation were the main climate factors that determined the potential distribution of the two species. The centroids of T. chinensis and T. mairei were in Sichuan and Hunan provinces in current period, respectively. In the future, the centroid migration direction of the two species would shift towards northeast. Our results revealed that the average elevation distribution of T. chinensis was higher than that of T. mairei. This study sheds new insights into the habitat preference and limiting environment factors of the two related species and provides a valuable reference for the conservation of these two threatened species.
Geopolymer‐based sub‐ambient daytime radiative cooling coating
Authors: Yang Ning , Fu Yang , Xue Xiao , Lei Dangyuan , Dai Jian‐Guo 
Published: September 2022

AbstractSub‐ambient daytime radiative cooling coating (SDRCC) is an appealing thermal management technology with great potential for alleviating the global warming and urban heat island effect. Over the past few years, various polymeric SDRCCs have been developed. However, they may face problems of environmental aging under UV and moisture due to their organic nature. In this study, an ambient‐cured inorganic geopolymer‐based SDRCC was synthesized with the modification of barium sulfate (BaSO4) and nano‐silica (SiO2) particles. The optical and physicochemical properties were systematically investigated. The chemical composition, functional groups, surface morphologies of the raw materials, and the formed geopolymer coating were characterized by XRD, FTIR, SEM, and EDS. The developed coating exhibits a high infrared emissivity of 0.9491 and solar reflectance of 97.6%. When exposed to direct sunlight, the coating's surface could cool down up to 8.9 °C below the ambient air temperature under Hong Kong's climate. In addition, the coating could retain well its performance under a variety of harsh environments, including high temperature, water immersion, mechanical wearing, and exposure to sunlight.
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Transcriptome and metabolome integration in sugarcane through culm development
Authors: Perlo Virginie , Furtado Agnelo , Botha Frederik C. , Margarido Gabriel R. A. , Hodgson‐Kratky Katrina , Choudhary Hemant , Gladden John , Simmons Blake , Henry Robert J. 
Published: September 2022

AbstractSugarcane (Saccharum sp.) is a tropical and subtropical C4 plant with a high photosynthetic and carbon assimilation efficiency that stores sucrose. Culm biomass is also composed of bagasse fibre, a by‐product of the sugarcane industry. This high‐yielding grass, high in sucrose and lignocellulosic biomass, is considered an optimal feedstock as an alternative to fossil fuels and to produce a broad range of high‐value biomaterials. The ideal sugarcane production system would optimise the relative production of sugar and these new products. Multi‐omics correlation analysis was used to generate a global view of the essential metabolic pathways identifying critical genes involved in carbon partitioning during different stages of development. This research employed an unprecedented metabolic and transcriptomic dataset of 360 samples from a selection of 1440 culms of 24 genotypes at five different development stages. Chemical composition and metabolome analysis showed an increase through the culm development of lignin, sucrose, carbon, and amino acids such as aspartic acid, serine, alanine, methionine, threonine 3‐cyano‐L‐alanine, and citric acid. Transcriptome analysis revealed functionalities such as transcription, nucleotide transport and metabolism, and the biosynthesis of amino acids that are highly activated during the immature stage and highly down‐regulated during the most mature age.
Miso: A traditional nutritious & health‐endorsing fermented product
Authors: Saeed Farhan , Afzaal Muhammad , Shah Yasir Abbas , Khan Mujahid Hassan , Hussain Muzzamal , Ikram Ali , Ateeq Huda , Noman Muhammad , Saewan Shamaail A. , Khashroum Ashraf O. 
Published: September 2022

AbstractConsumer demand for fermented foods with a well‐balanced nutrient profile has been increasing owing to their ability to prevent chronic diseases as well as their functional, nutritional, and nutraceutical benefits. Among those functional foods, miso is a well‐known traditional fermented food with a distinctive savory flavor and aroma that is most commonly used as a seasoning in miso soup. Among different fermented products, miso is derived from soybeans and grains as a result of the activities of Koji enzymes and beneficial microbes. Additionally, the microbial community of miso is thought to be crucial in enhancing its distinct flavor and texture as well as its nutritional properties. Despite the importance of microorganisms in the production of miso, there has been relatively little research done to characterize and describe the nutritional and medicinal potential of miso. In this review, the potential therapeutic properties, i.e., anticancer, antimicrobial, and antiobesity, of miso have been discussed comprehensively. This review envisions the production technology, its history, microbial population, nutritional properties, and the potential health benefits of miso associated with its consumption.
Improving the adsorption characteristics and antioxidant activity of oat bran by superfine grinding
Authors: Zhang Yakun , Zhang Meili , Guo Xinyue , Bai Xue , Zhang Jing , Huo Rui , Zhang YuanYuan 
Published: September 2022

AbstractOat bran (OB) is a by‐product of oat, which is rich in β‐glucan. As a new food processing technology, ultrafine powder can improve the surface properties of samples. OB with different grinding times was prepared, and its functional components, physical properties, adsorption properties, and antioxidant properties were evaluated. Results showed that with increased grinding times, the average particle size of OB decreased significantly (p < .05). And the water‐holding capacity, swelling capacity, and water solubility index of OB increased significantly (p < .05), whereas the animal and vegetable oil‐holding capacities decreased. Oat bran could adsorb cholic acid and glucose, which was related to the time of superfine grinding. In addition, the antioxidant capacity of OB was improved after superfine grinding. Related analysis shows that there was significant positive relationship between β‐glucan, polyphenols and soluble dietary fibers and antioxidant indicators (p < .05). The Fourier transform infrared (FTIR) results showed that the FTIR spectra of OB powder with different crushing times were similar. On the basis of the above analyses, it is suggested that OB prepared by superfine grinding for 5 min had good physical and chemical properties and antioxidant properties and is widely used in food.
A quantitative prevalence of Escherichia coliO157 in different food samples using real‐time qPCR method
Authors: Pakbin Babak , Brück Wolfram Manuel , Brück Thomas B. , Allahyari Samaneh , Ashrafi Tamai Iradj 
Published: September 2022

AbstractEscherichia coli serogroup O157 is the main causative agent of several intestinal and extra‐intestinal foodborne diseases in humans through consumption of low‐dose contaminated foods such as milk, beef, and vegetables. To date, studies regarding the quantitative prevalence of E. coli O157 in foods are so limited. Therefore, this study aimed to evaluate the quantitative prevalence rate of E. coli serogroup O157 in raw milk (n = 144), vegetable salad (n = 174), and minced beef samples (n = 108) using the real‐time qPCR SYBR green melting curve method targeting the rfbA gene. First, we evaluated the method and found a sensitive and specific qPCR assay with 1 log of CFU/ml detection limit to detect E. coli O157 (Tm = 80.3 ± 0.1°C). About 2.77%, 10.18%, and 9.19% of raw milk, minced beef, and vegetable salad samples, respectively, were contaminated with E. coli O157. Minced beef and vegetable salad samples were significantly more contaminated than raw milk samples. Population average of E. coli O157 in raw milk, minced beef, and vegetable salad samples were 2.22 ± 0.57, 3.30 ± 0.40, and 1.65 ± 0.44 log CFU/ml or gr, respectively. Significantly higher levels of population of E. coli O157 were observed in minced beef samples. Minced beef can be regarded as the main food in the transmission of this foodborne pathogen. Routine quantitative rapid monitoring is strongly suggested to be carried out to prevent foodborne diseases caused by E. coli O157.
A global drought monitoring system and dataset based on ERA5 reanalysis: A focus on crop‐growing regions
Authors: Vicente‐Serrano Sergio M. , Domínguez‐Castro Fernando , Reig Fergus , Tomas‐Burguera Miquel , Peña‐Angulo Dhais , Latorre Borja , Beguería Santiago , Rabanaque Isabel , Noguera Ivan , Lorenzo‐Lacruz Jorge , El Kenawy Ahmed 
Published: September 2022

AbstractDrought monitoring systems are real‐time information systems focused on drought severity data. They are useful for determining the drought onset and development and defining the spatial extent of drought at any time. Effective drought monitoring requires databases with high spatial and temporal resolution and large spatial and temporal coverage. Recent reanalysis datasets meet these requirements and offer an excellent alternative to observational data. In addition, reanalysis data allow better quantification of some variables that affect drought severity and are more seldom observed. This study presents a global drought dataset and a monitoring system based on the Standardized Precipitation Evapotranspiration Index (SPEI) and ERA5 reanalysis data. Computation of the atmospheric evaporative demand for the SPEI follows the FAO‐56 Penman‐Monteith equation. The system is updated weekly, providing near real‐time information at a 0.5° spatial resolution and global coverage. It also contains a historical dataset with the values of the SPEI at different time scales since January 1979. The drought monitoring system includes the assessment of drought severity for dominant crop‐growing areas. A comparison between SPEI computed from the ERA5 and CRU datasets shows generally good spatial and temporal agreement, albeit with some important differences originating mainly from the different spatial patterns of SPEI anomalies, as well as from employing long‐term climate trends for different regions worldwide. The results show that the ERA5 dataset offers robust results and supports its use for drought monitoring. The new system and dataset are publicly available at the link https://global‐drought‐crops.csic.es/.
Combination of PD‐1/PD‐L1 checkpoint inhibition and dendritic cell therapy in mice models and in patients with mesothelioma
Authors: van Gulijk Mandy , Belderbos Bob , Dumoulin Daphne , Cornelissen Robin , Bezemer Koen , Klaase Larissa , Dammeijer Floris , Aerts Joachim 
Published: September 2022

AbstractImmunotherapy with anti‐PD1/PD‐L1 is effective in only a subgroup of patients with malignant pleural mesothelioma (MPM). We investigated the efficacy of a combination of anti‐PD1/PD‐L1 and dendritic cell (DC) therapy to optimally induce effective anti‐tumor immunity in MPM in both humans and mice. Data of nine MPM patients treated with DC therapy and sequential anti‐PD1 treatment were collected and analyzed for progression‐free survival (PFS) and overall survival (OS). Survival and T‐cell responses were monitored in AC29 mesothelioma‐bearing mice treated concurrently with the combination therapy; additionally, the role of the tumor‐draining lymph node (TDLN) was investigated. The combination therapy resulted in a median OS and PFS of 17.7 and 8.0 months, respectively. Grade 3 to 4 treatment‐related adverse events had not been reported. Survival of the mesothelioma‐bearing mice treated with the combination therapy was longer than that of untreated mice, and coincided with improved T‐cell activation in peripheral blood and less T‐cell exhaustion in end stage tumors. Comparable results were obtained when solely the TDLN was targeted. We concluded that this combination therapy is safe and shows promising OS and PFS. The murine data support that PD‐L1 treatment may reinvigorate the T‐cell responses induced by DC therapy, which may primarily be the result of TDLN targeting.
Geometric, spintronic, and opto‐electronic properties of 3d transition metals doped silicene: An ab initio study
Authors: Kalwar Basheer Ahmed , Fangzong Wang , Saeed Muhammad Hammad , Bhutto Aqeel Ahmed , Tunio Mohsin Ali , Bhagat Kalsoom 
Published: September 2022

AbstractThis study shows density functional theory (DFT) investigations that 3d transition metals (TM) doping in silicene can greatly alter the geometric, spintronic, and optoelectronic properties of the pristine silicene (p‐Si) layer. Significant Bader charge transfer from 3d TM atoms to surrounding Si atoms ensures the tight bonding between dopant and substrate; hence, all the 3d transition metal‐doped silicene (3d TM‐Si) systems are said geometrically strong and stable. Sc‐ and Ti‐doped systems show the lowest formation energies of −84.72 and −84.21 eV, respectively, while Zn‐Si bears the highest (−70.89 eV). 3d TMs from V to Co doping induces magnetic moment (MM) in the silicene layer which mainly comes from d‐orbitals of 3d TM atoms and partly from p‐orbitals of Si atoms, meanwhile Mn‐Si has MM as high as 3.0 μB. Among 3d TM‐Si systems studied, Cr‐Si and Mn‐Si systems became half metals, Ti‐Si became indirect semiconductor, whereas rest others convert into metals. Sc and V doping is found to be p‐type doping as the Fermi level shifts into the valence band. Moreover, multiple and broader peaks in the absorption coefficient plot indicate the significant photoabsorption of 3d TM‐Si systems. The present study of electronic, magnetic, and optical properties of 3d TM‐Si systems extend a helpful proposal for further experimental work to fabricate silicene‐based single‐spin electron source and other nano‐electronic devices.
Routine outcome monitoring: The need for case examples
Authors: de Jong Kim , Aafjes‐van Doorn Katie 
Published: September 2022

AbstractRoutine outcome monitoring (ROM) involves measuring an outcome variable (e.g., symptoms and alliance) at a regular interval over time (e.g., before each session), using a standardized patient self‐report measure. Several computerized ROM system exists that also provide the therapist with benchmarks for these measures based on expected treatment responses (ETRs) for a patient, and clinical support tools (CSTs) to help the therapists in making clinician decisions in the treatment. When implementing ROM into clinical practice, a therapist needs to decide what patient‐self report measure to use as well as what ROM system might be most clinically helpful and cost‐effective. Although the use of ROM has shown to be effective, especially in reducing dropout and reducing deterioration of patients, the implementation of ROM can be challenging. The use of ROM always requires the active involvement of the therapist, but the implementation in treatment may look different for each patient. It is thus helpful to see case illustration of exactly how ROM might be useful or not so useful in clinical practice.
A Tribute to the Pioneers of Fetal Pharmacology
Authors: Bhatt‐Mehta Varsha , Ward Robert M. , Zajicek Anne , Giacoia George P. , Burckart Gilbert J. 
Published: September 2022

AbstractClinical pharmacology is a branch of the field of pharmacology that evolved following the recognition that the nature, duration, and intensity of drug action depend on both the intrinsic properties of the drug and an interaction with the host to whom the drug is given. Advances in drug development have placed highly specific and extremely potent therapeutic agents in the marketplace. While these advances have progressed rapidly in adult medicine, pediatric clinical pharmacology has not kept pace and until very recently has lagged behind the research and attention paid to the proper use of therapeutic and diagnostic drugs in adults. Recognition that advances in the science of developmental pharmacology and pediatric clinical pharmacology were essential in the development of new drugs to treat children came in the 1950s and 1960s mostly through the work of 2 pioneering scientists in fetal and perinatal clinical pharmacology, Drs Sumner Yaffe and Bernard Mirkin. Here we pay a tribute to these most influential pioneers in the United States who were instrumental in paving the path for advancing the field of fetal and perinatal pharmacology concepts and their incorporation into pediatric drug development programs.
Knowledge, Attitude, and Beliefs of Medication Use in Pregnancy in an Urban Tertiary Care Center
Authors: Kazma Jamil , Araji Tarek , Khilnani Aneka , van den Anker John , Ahmadzia Homa K. 
Published: September 2022

AbstractMedication use in pregnancy is common. However, there is a gap in the literature assessing the knowledge of pregnant individuals about medication use in pregnancy. The aim of our study is to assess the knowledge, attitudes, and beliefs of pregnant people on medication use in pregnancy. We conducted a cross‐sectional survey questionnaire that was completed by pregnant patients from December 2021 to January 2022. The survey included questions regarding knowledge, attitude, and sources for obtaining information about medication use in pregnancy and general statements from the Beliefs about Medicines Questionnaire (BMQ). A total of 150 participants completed the survey. Most patients reported that a person should know that medication use for chronic diseases must be modified during pregnancy and that medications can be used in any trimester of pregnancy. Most reported that medication use can lead to fetal growth restriction and maternal bleeding. The mean scores (SDs) on the BMQ‐General for the overuse, harm, and benefit statements were 8.7 (2.4), 8.2 (3.1), and 15.7 (2.8). Even though medication use in pregnancy is common, it is an area of concern to pregnant patients. More research on identifying the risks of different medicines used in pregnancy is thus needed.
Correlation between preoperative imaging biomarkers and histological prognostic factors in endometrial cancer: A prospective study
Authors: Perniola Giorgia , Derme Martina , Manganaro Lucia , Satta Serena , Palaia Innocenza , Di Donato Violante , Muzii Ludovico , Panici Pierluigi Benedetti 
Published: September 2022

AbstractPurposeWe compared transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI) for detecting myometrial infiltration, cervical involvement, and for measuring tumor volume in endometrial cancer patients. We also correlated tumor volume to worse histological prognostic factors.MethodsWe recruited women with a histological diagnosis of endometrial cancer between March 2019 and March 2021. Inclusion criteria were: age ≥ 18 years, written informed consent, biopsy‐proven endometrial cancer, absence of previous neoadjuvant chemo‐ or radiotherapy treatment, patient suitable for primary surgery. Exclusion criteria were: advanced disease stage and other coexisting malignant tumors. TVUS and MRI were used, in the absence of any contraindication. We compared the preoperative imaging results with final histopathology.ResultsThe accuracy of TVUS and MRI in evaluating myometrial infiltration, cervical invasion and tumor volume were comparable. A tumor volume ≥2 ml showed a positive correlation with worse histological prognostic factors, such as high tumor grade, diffuse lymphvascular space involvement (LVSI) and deep myometrial invasion (p < 0.05).ConclusionTVUS should be used as first‐line imaging modality, being more available, cost‐effective, and more acceptable by patients. A careful local staging of endometrial cancer patients before surgery is fundamental in order to improve tailored treatment and minimize costs.