bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects from oral administration of recombinant interferon-alpha on piglet daily care
Authors: Dai Fawen , Liu Yanting , Zhang Meimei , lin Tao , Chu Huashuo , Gong Ruixue , Zhao Baokai 
Published: January 2022

Abstract
The administration of interferon has improved the antiviral and immunomodulatory abilities of piglets, which is conductive to the prevention of potential diseases or delay the appearance of clinical symptoms. This study aimed to evaluate the effects from administration of recombinant interferon-alpha (IFN-α) on the daily care of piglets. The results were compared with compound Chinese herbal, which was proved to improve serum interferon level. Further, the administration routes were compared between oral administration and intramuscular injection. Forty (40) piglets with equal age and weight were randomly divided into four groups: Control group (Group C, without treatment), Group H (treated with compound Chinese herbal), Group K (administered orally with recombinant IFN-α, 1500 IU per day per piglet), and Group J (administered intramuscularly with IFN-α, 4× 106 IU per day per piglet). After the treatment of 15 days, both oral and intramuscular treatment of recombinant IFN-α significantly improved the secretion of IFN-gamma (IFN-γ) (P<0.05), and the effects of intramuscular pathway were faster. In addition, the expression levels of IFN-stimulated genes (MX1 and ISG15) were significantly enhanced (P<0.01), independently of IFN-α treatment time and serum IFN-γ level. Different from other studies, compound Chinese herbal showed weaker effects on interferon stimulation in piglets. The results indicated that oral administration of recombinant IFN-α improved interferon-induced response of piglets at both serum and molecular levels, which may be applied for improving autoimmunity of piglets.
Microstructural Evaluation of Thermal Stabilization of Marl Soils Considering Permeability Variations
Authors: Amiri Mohammad , Dehghani Masoud , Papi Maedeh 
Published: January 2022

Abstract
Heat alters the engineering behavior of soils. Marl soils are highly-erodible sedimentary deposits composed of clay minerals and calcium carbonate. Clay minerals and calcium carbonate in marl soils considerably influence the engineering behavior of such soils. Soils can be exposed to heat for a variety of reasons leading to changes in the physical, mechanical, and microstructural properties, in particular the engineering properties of marl soils. In the design of geo-environmental projects, the results of soil mechanics, especially the permeability coefficient, directly influence the design outcomes. Accordingly, this study aimed at evaluating the effect of heat treatment on the engineering behavior and permeability coefficient of marl soils from a microstructural perspective. To this end, the marl soil was heated to 25–900°C for 2 h. The changes in the engineering properties of marl soils at different temperatures were studied by macrostructural (gradation, Atterberg limits, loss-on-drying, Unconfined Compressive Strength (UCS) and permeability) and microstructural (XRD and SEM) investigations. The results were suggestive of the considerable effect of heat treatment on the engineering behavior of marl soils, as the compressive strength of marl soils increased by 100 folds, and the permeability coefficient reduced by about 6 times at 700°C.
Highly selective behaviour of colon adenoma after administration of EMR composition and its HCT116-based model.
Authors: Jakabčin Patrik , Kello Martin , Záň Jozef , Kolář Josef , Ulicny Jozef 
Published: January 2022

Abstract
When applying the improved composition of the solution used during endoscopic mucosal resection (EMR), we observed unexpectedly large and quantitatively significant differences in adenoma response vs. healthy tissue of the surrounding GIT tract, namely, the selective reaction enhancing the adenoma volume and differentiated colour. The in vitro experiments on the model neoplasia cell line HCT116 suggest that the robust differences in the response of starving cells can be traced down principally to tetrastarch digestion and the enhanced metabolic rate of neoplastic cells. The neoplastic tissue grows into several intestine layers so that submucosal injection of iso-oncotic tetrastarch compound leads to degradation of starch and production of oncotic molecules in submucosa transported by facilitated transport into the neoplastic tissue. The colour distinction is due to concentration differences of the reporting dye between three separated compartments, further enhancing the utility of the contrasting mixture. The diffusion dynamics shall be tuneable by optimizing starch composition, improving desirable pharmacokinetics.
Utilization of Bitter orange seeds as a novel source for recovery of pectin: Compositional and rheological characterization
Authors: Khodaei Diako , Nejatian Mohammad , Gavlighi Hassan Ahmadi , Garavand Farhad , Cacciotti Ilaria 
Published: January 2022

Abstract
The seeds from bitter orange, a by-product from the juice making step, hold the potential to facilitate novel, easy yet high quality pectin extraction. To test this hypothesis, the pectin from orange seeds (OSP) were extracted by distilled water and its compositional parameters and rheological behavior then evaluated. Results showed that galacturonic acid was the major component of OSP (~ 425 mg/g) confirming the purity of extracted pectin, followed by glucose and some minor neutral sugars. Mw, Rn and, Rz for the OSP were 4511.8 (kDa), 61 (nm), and 61.1 (nm), respectively. Rheological measurements showed shear-thinning behavior for OSP that by increasing temperature from 5 to 45 oC, the viscosity of the gum decreased. Power law fitted as the best rheological model describing the flow behavior of OSP. Strain sweep dynamic rheological measurements confirmed an entangled network structure for OSP and the addition of NaCl to the gum dispersion, decreased the consistency coefficient from 35.6 to 23.18 Pa.sn, while the flow behavior index remained unchanged. These results demonstrate for the first time that the OSP can be used as a new source of pectin, with likely a wide range of applications in food industry.
Role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to stress-induced anxiety
Authors: Rakotobe Malalaniaina , Fjerdingstad Niels , Ruiz-Reig Nuria , Lamonerie Thomas , D'Autréaux Fabien 
Published: January 2022

Abstract
Experiencing stress during sensitive periods of brain development has a major impact on how individuals cope with later stress. Although many become more prone to develop anxiety or depression, some appear resilient. The mechanisms underlying these differences are unknown. Key answers may lie in how genetic and environmental stressors interact to shape the circuits controlling emotions. Here we studied the role of the habenulo-interpeducuncular system (HIPS), a critical node of reward circuits, in early stress-induced anxiety. We found that a subcircuit of this system, characterized by Otx2 expression, is particularly responsive to chronic stress during puberty, which induces HIPS hypersensitivity to later stress and susceptibility to develop anxiety. We further show that Otx2 deletion restricted to the HIPS counteracts these effects of stress.
Together, these results demonstrate that Otx2 and stress interact, around puberty, to shape the HIPS stress-response, revealed here as a key modulator of susceptibility/resilience to develop anxiety.
Einstellungen und Bewertungen von Eltern an reformpädagogischen Schulen zur medienerzieherischen Praxis
Authors: Kernbach Julia , Bleckmann Paula , Streit Benjamin , Pemberger Brigitte 
Published: January 2022

Bisher sind Eltern als zentrale Akteure gelingender Medienbildung nach ihrem medienerzieherischen Handeln in der Familie, aber kaum nach einer differenzierten Bewertung der schulischen Praxis befragt worden. Für die MünDig-Studie, eine bundesweit im Herbst 2019 durchgeführte Onlinebefragung von Eltern, älteren Schülerinnen und Schülern und Lehrkräften an reformpädagogischen Schulen, erwiesen sich gängige Befragungsinstrumente als ungeeignet. Daher wurde ein multidimensionales Befragungsinstrument entwickelt, das medienerzieherische Einstellungen und Aktivitäten differenziert nach verschiedenen Medien (mit und ohne Bildschirm), dem Alter des Kindes sowie Lern-/Bildungszielen (Medienkompetenzrahmen NRW plus 4 zusätzliche Bereiche) erfasst. Die in der MünDig-Studie befragten Montessori- und Waldorfeltern bewerten die schulische medienerzieherische Praxis mehrheitlich positiv, sehen jedoch in Teilbereichen Defizite. Zufriedenheit zeigt sich bezüglich des pädagogischen Ansatzes, der «ein selbständiges, kritisches Denken und Handeln unterstützt» (88 %) und der Förderung von Medienmündigkeit durch den Einsatz von Medien ohne Bildschirm (88 %). Für die oberen Klassen wird mehr Einsatz digitaler Bildschirmmedien gewünscht (Eltern-Zufriedenheit 70 % in den Klassen 1-3, 44 % in den Klassen 10-13), ebenso deutlich mehr pädagogische wie technische Unterstützung. Zufriedenheit besteht über Aktivitäten der Schule, die Kinder und Jugendliche im sozialen Miteinander (74 %) zum Schutz vor Digital-Risiken im realen Leben stärken. Erstmals ermöglichen die entwickelten innovativen Bewertungsdimensionen die Beschreibung einer interessanten medienerzieherischen Haltung, die jenseits einer angenommenen Dichotomie «bewahrpädagogische» wie auch «aktiv-handlungsorientierte» Ansätze zu vereinen scheint.
Comparison of mini-screw-assisted rapid maxillary expansion in adolescents with different body mass indices: a prospective clinical study
Authors: Buyuk Suleyman Kutalmış , Simsek Huseyin , Hatal Sedanur , Sarımehmetoglu Nilge , Odabası Didem 
Published: January 2022

Abstract

Objectives
The objective of the present study was to compare the dentoskeletal effects of mini-screw-assisted rapid maxillary expansion (RME) in children with different body mass index (BMI) percentiles.

Study design
The study was performed on 20 patients who were divided into two groups based on their BMI percentiles as normal-weight (n = 10) and overweight-obese (n = 10). The linear, angular and area analyses were performed on lateral and postero-anterior cephalometric radiographs and three-dimensional dental models before and after RME therapy.

Results
A statistically significant increase was observed in maxillary intermolar and intercanine distances and palatal area measurements in both groups (P < 0.05). There was no significant difference between the two groups when dental RME changes were measured on 3D models. A significant difference was observed in latero-nasal and maxillo-mandibular width as well as postero-anterior cephalometric parameters between the groups (P < 0.05). While a significant change was observed in the SN-GoMe, FMA, Z angle, Wits appraisal, total anterior facial height and lower anterior facial height parameters in the normal-weight group (P < 0.05), a statistically significant change was observed in the gonial and nasolabial angles in the overweight-obese group.

Conclusions
Mini-screw-assisted RME treatment significantly increased maxillary intermolar and intercanine width, and the palatal area in both groups; however, there was no significant difference between the BMI groups.
MOTOR IMAGERY ABILITY IN TURKISH-SPEAKING STROKE PATIENTS: STUDY ON RELIABILITY AND CONSTRUCT VALIDITY STUDY OF TWO IMAGERY QUESTIONNAIRES
Authors: DİLEK Burcu , ARSLAN Büşra , HANOĞLU Lütfü 
Published: January 2022

Purpose: Motor imagery is considered as a complementary approach for functional recovery after stroke. Thus, applying reliable assessment tools to measure imagery ability in stroke is essential. The aims of this study were to apply Turkish versions of the Movement Imagery Questionnaire-3 (MIQ-3) and the Kinesthetic and Visual Imagery Questionnaire-20 (KVIQ-20) in individuals with stroke and investigate the validity and reliability of both questionnaires.
Methods: Stroke patients with mild functional impairments (n=31) and healthy volunteers who age- and
gender-matched were selected as a control group (n=29) were recruited to the study. The test-retest reliability was assessed using intra-class correlation coefficients (ICCs). Spearman’s correlation analysis
was performed to assess concurrent validity of the KVIQ-20 with the MIQ-3. Furthermore, the internal
consistency (Cronbach’s alpha) and factorial structures of both questionnaires were investigated.
Results: Each sub-score of the MIQ-3 was found statistically different between stroke and control groups (p
From a millennium to a sustainable water and sanitation development: were we there already?
Authors: Pereira M. A. , Marques R. C. 
Published: January 2022

Abstract
The Sustainable Development Goals (SDGs) of the United Nations (UN) brought many countries closer to the best practices in several sectors. However, regarding water and sanitation services (WSS), the evolution from the original Millennium Development Goals (MDGs) is not yet understood. Therefore, analysing whether low- and middle-income nations were able to converge in terms of WSS is fundamental for policy-making. Here, we propose a benchmarking exercise aimed at assessing the performance of 123 low- and middle-income UN Member States regarding WSS development targets over the 2001–2015 period of MDG pursuance. In the end, we show that, on average, the assessed Member States were already fully convergent before the implementation of the SDGs, despite further improvements with the latter. Additionally, we show that all UN regional groupings were able to decrease not only the performance spread of their Member States, but also the gap between the best practice frontier and the worst practice frontier. Besides, the Proportion of population using an improved drinking water source was the indicator with the highest performance growth in the considered period.
Determination of morphological parameters of Tidi watershed using remote sensing and geographic information system approaches
Authors: S. V. Lakshminarayana , Singh Pradeep Kumar , Rajdhar Patil Pravin , Jain Abhishek 
Published: January 2022

Abstract
In the current study, an attempt was made to determine the morphological parameters of the Tidi watershed in Udaipur district of Rajasthan, India. Remote sensing and geographic information system (GIS) technique has proved to be an efficient tool in drainage network delineation and update in morphological analysis. For detailed study, ASTER DEM was used for delineation of the watershed boundary, and GIS was used in evaluation of basic, linear, areal and relief aspects of morphometric parameters. The Tidi watershed occupies an area of 114.36 km2 with a dendritic drainage pattern. The study area is designated as fifth order basin and lower and middle order streams mostly dominate the basin with the drainage density value of 1.74 km/km2 which exhibits gentle to moderate slope terrain and medium dense vegetation. The mean bifurcation value of the watershed is 3.88 and the value varies from 2 to 4.14 which shows that the drainage network formed on homogeneous rocks when the influences of geologic structures on the stream network were negligible. An elongation ratio of 0.79 implies that the watershed is less elongated in shape. The results from the morphometric analysis of the watershed are very beneficial for developing and designing conservation structures of soil and water and watershed management measures.
Modeling the hydrological characteristics of Hangar Watershed, Ethiopia
Authors: Galata Abdata Wakjira 
Published: January 2022

Abstract
The hydrologic characteristics of the Hangar Watershed were modeled by using the Soil and Water Assessment Tool (SWAT) model. Digital elevation model, land use/land cover data, soil map, weather, and hydrological data were among the data used for this study. The measured streamflow data of (1990–2002) and (2003–2011) years were used for calibration and validation of the model, respectively, and its performance was good for both calibration and validation. The sensitivity analysis identified that the watershed is characterized by 13 sensitive parameters. The watershed receives around, 9.6%, 59.9%, and 30.5% precipitation during dry, wet and short rainy seasons, respectively. The received precipitation was lost by 9.6%, 40.5%, and 41.3% in the form of evapotranspiration for each season, correspondingly. The surface runoff contribution to the watershed was 3.8%, and 79.2% during dry and wet seasons, respectively, whereas it contributes by 17.0% during short rainy seasons.
Avaliação da utilização do Portal Capes de periódicos na ótica dos usuários pesquisadores em administração e contabilidade com base na escala SERVQUAL
Authors: Colares Ana Carolina Vasconcelos , Cássia de Oliveira Ferreira  
Published: January 2022

Objetivo: O objetivo desta pesquisa é avaliar a utilização do Portal Capes de Periódicos na ótica dos usuários pesquisadores em administração e contabilidade, e investigar a relação entre a satisfação do usuário com as cinco dimensões do modelo SERVQUAL de avaliação de serviços.
Metodologia: A escala foi respondida por 162 pesquisadores das áreas de contabilidade e administração, os quais foram contactados através de e-mail disponível nas publicações de periódicos Qualis A2 e B1 no ano de 2017. Foi utilizado um modelo análise de regressão múltipla tendo o nível de satisfação (ST) como variável dependente do modelo, e como variáveis independentes a confiabilidade (CF), responsividade (RP), segurança (SG), empatia (EP) e os aspectos tangíveis (TG), mensurados através da escala SERVQUAL utilizada. O modelo foi testado e validado quanto aos problemas de multicolinearidade (Teste Variância da Inflação – VIF), heterocedasticidade (Breush Pagan) e forma funcional (Ramsey Reset).
Resultados: O perfil predominante dos pesquisadores em contabilidade e administração são professores com doutorado em universidades públicas, que utilizam o portal de periódicos com alta frequência, embora não estejam totalmente satisfeitos com o serviço. Constatou-se uma relação positiva significativa entre a satisfação do serviço e as variáveis de tangibilidade, confiança, segurança e empatia. A responsividade não foi constatada como variável significativa.
Contribuições do estudo: Observou-se que a referida plataforma tem muitas vantagens, mas algumas características ainda deixam a desejar, mostrado, por exemplo, a partir da avaliação da tangibilidade que está diretamente relacionada à interface. E, também a responsividade que é a dimensão que avalia a receptividade e feedback da entidade que opera o portal, impactando negativamente na satisfação, o que pode ser explicado pela ausência de contato ou relação entre o usuário e a equipe responsável pelas operações no Portal Capes.
Aplicabilidade dos modelos CAPM local, CAPM local ajustado e CAPM ajustado híbrido ao mercado brasileiro
Authors: Paiva Martins Teixeira Vandliny , Ferreira da Cunha Moisés , Renata dos Santos Thaisa 
Published: January 2022

Objetivo: O objetivo desta pesquisa é verificar a aplicabilidade dos modelos CAPM local, CAPM Local Ajustado e CAPM Ajustado Híbrido ao mercado brasileiro, a partir da análise de suas respectivas premissas e, adicionalmente, verificar a existência de diferenças estatísticas significativas entre os modelos.
Metodologia: Para os indicadores escolhidos, objetivando representar as premissas de cada modelo, é testada a série história de 2007 a 2014, compreendendo uma amostra de 94 empresas mais líquidas do mercado brasileiro avaliadas conforme os modelos de precificação de ativos CAPM Local, CAPM Local Ajustado e CAPM Ajustado Híbrido. São realizados testes estatísticos (com confiabilidade de 95%), por meio do programa ASSISTAT versão 7.7 beta para as análises das estatísticas descritivas, comparado posteriormente por meio de um teste não paramétrico e também com estimativa de correlação.
Resultados: As comparações múltiplas após as premissas indicam que as diferenças ocorrem entre os modelos CAPM Local e CAPM Local Ajustado e entre CAPM Local Ajustado e CAPM Ajustado Híbrido. Os resultados apontam uma correlação positiva entre os retornos do Embi + Br e do T-Bond 10 e 30 anos. Teoricamente, esta correlação não é esperada, uma vez que o risco país não deveria estar correlacionado às taxas livres de risco globais. O Ibovespa apresenta correlação positiva com o MSCI ACWI e com o S&P 500, um resultado que evidencia a correlação entre os retornos de mercado local e global. A Selic apresenta correlação negativa com o Ibovespa, pois, teoricamente a taxa livre de risco local não deveria ser correlacionada ao retorno de mercado local.
Contribuições do Estudo: A contribuição deste estudo é de que a aplicabilidade dos modelos CAPM local, local ajustado e ajustado hibrido ao mercado emergente brasileiro é possível para precificação de ativos, devendo se atentar para o fato de que os Betas Locais possuem influência nesses valores.
Desempenho dos maiores bancos brasileiros: um estudo sobre o impacto da crise subprime
Authors: Coeli Cristiana Maria , Martins Pires Vanessa 
Published: January 2022

Objetivo: Analisar o impacto da crise subprime no desempenho dos maiores bancos brasileiros, utilizando indicadores contábeis que permitem mensurar o comportamento dos índices de inadimplência, a evolução das despesas com Provisão para Devedores Duvidosos (PDD), do volume de ativos totais e dos índices de rentabilidade.
Metodologia: Informações dos cinco maiores bancos estabelecidos no Brasil (Banco do Brasil, Caixa Econômica Federal, Itaú Unibanco, Bradesco e Santander), no período entre 2008 e 2016, foram coletadas e analisadas. Os dados foram obtidos através de consultas no site do BCB e nos sites dos bancos. Os resultados obtidos foram sumarizados em gráficos e tabelas.
Resultados: O desempenho dos bancos foi afetado pelo aumento no volume de despesas com PDD no período, resultado de uma estratégia conservadora adotada pelas instituições. Identificou-se um aumento no volume de inadimplência, mas os bancos foram cautelosos mantendo níveis de PDD em volumes compatíveis ao crescimento das concessões de crédito. Todos os bancos apresentaram um crescimento no valor dos seus ativos totais. Em termos de rentabilidade, as instituições obtiveram desempenhos distintos. Destaca-se os valores expressivos de lucros auferidos pelos Bancos Bradesco e Itaú Unibanco no ano de 2015.
Contribuições do Estudo: A implantação de uma política monetária expansionista influenciou positivamente no desempenho dos bancos, principalmente nas instituições com controle estatal. A pesquisa evidencia que a crise subprime afetou o desempenho dos bancos, como consequência das ações conservadoras adotadas, a fim de proteger o Sistema Financeiro Nacional. A pesquisa contribui com a literatura, primeiramente, ao apresentar dados empíricos sobre os efeitos da crise subprime nas principais instituições bancárias brasileiras, e também por discutir os resultados à luz da teoria e da conjuntura econômica do período, permitindo diferentes interpretações sobre o impacto desse fenômeno.