bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dakwah Melalui Ekstrakulikuler : Aktivitas Rohis di SMA Negeri 2 Karimun
Authors: Pipir Romadi  , Siti Norhalida  
Published: December 2022

Masa remaja sering dipenuhi dengan berbagai keingin tahuan dari rasa keingin tahuan inilah mereka sanggup mengorbankan harga diri mereka, rasa penasaran yang tidak karuan menyebabkan mereka menjadi salah kaprah pergaulan yang tidak sehat menjadikan mereka remaja yang tidak baik pula, tawuran, pergaulan bebas,narkoba bahkan sampai seks bebas sudah tidak asing lagi kita dengar pada kalangan remaja pada saat ini terkhusnya pada kalangan remaja SMA. Oleh karena itu, dibutuhkan peran dari sekolah dalam membangun akhlak para siswa salah satunya yaitu sebagaimana yang diterapkan di SMAN 2 karimun dengan membentuk ekstrakulikuler rohis dengan berbagai program pembinaan yaitu melalui kegiatan open house, mabit, rihlah, pertualangan fajar,ngerujak dan juga kajian mingguan.
Use of polyclonal antibodies in brain-dead donors in kidney transplantation
Authors: Kuzmin D. O. , Manukovsky V. A. , Bagnenko S. F. , Reznik O. N. , Ananiev A. N. , Vorobyeva O. A. , Vorobyev S. L. , Gogolev D. V. , Daineko V. S. , Kutenkov A. A. , Chichagova N. A. , Uliankina I. V. 
Published: December 2022

Objective. The objective of this study is to develop a therapeutic strategy for protecting grafts in order to improve the efficiency of kidney transplantation (KT) using polyclonal antibodies (pAbs) through elimination of activated forms of neutrophils, chemo- and cytokines from the donor’s bloodstream, and a decrease in the level of expression of adhesion molecules on the renal vascular endothelium at the pre-transplant stage.Materials and methods. In 2017, we developed and for the first time applied a therapeutic strategy for ischemia-reperfusion injury (IRI) in a brain-dead donor (BDD). Given the limited time interval after brain death has been diagnosed, Timoglobulin (Sanofi Genzyme, France) was administered to the donor at a dose of 8 mg/kg intravenously for 6 hours. Before drug administration and immediately before the start of cold perfusion, a complete blood count and renal transplant biopsy were performed. The study group included 10 BDDs (mean age 39.3 ± 4.4 years) who received anti-thymocyte globulin (ATG). The comparison group included 10 BDDs (mean age 38.5 ± 4.3 years) who did not undergo the new strategy. Donor kidneys were transplanted to 40 recipients (average age 47.5 ± 4.3 years), who were also divided into 2 groups, depending on the graft received (with and without ATG). At the organ donation center, a biobank of specimens from donors of various categories, including those using the IRI therapeutic strategy and recipients for retrospective assessment of the effectiveness of pAbs, was formed.Results. Clinical blood test results show that in the ATG group, there was stable leukopenia (neutropenia and lymphopenia) of 1.46 ± 0.18x109/l. Fifteen (75%) recipients of kidneys obtained from donors with ATG had immediate graft function; in the control group – 10 (50%) recipients.Conclusion. Data obtained testify to the prospects of implementing the proposed strategy in clinical practice, which will improve the quality of the resulting grafts and their suitability for subsequent transplantation, prolong graft functioning due to elimination of leukocytes as a factor of IRI, prevention of early allograft nephropathy, increase in the donor pool by using expanded criteria donors (ECDs).
Mechanized lymphatic drainage in acute decompensated heart failure. A study on a hydrodynamic test bench
Authors: Buchnev A. S. , Itkin G. P. , Drobyshev A. A. , Kuleshov A. P. , Esipova O. Yu. , Syrbu A. I. 
Published: December 2022

Objective: to investigate the effectiveness of a new mechanized lymphatic drainage method in acute decompensated heart failure (ADHF) modeling through local reduction in venous pressure in the site of lymphatic drainage from the thoracic duct.Materials and methods. Main components of the device are a catheter with built-in inlet and outlet mechanical valves designed for insertion into the left brachiocephalic vein through the left internal jugular vein. It comes with an extracorporeal drive system made as a valveless pulsator pump with a 10 ml shock discharge and a controller ensuring preset frequency and pressure/rarefaction duty cycle. The operating principle of the device is based on local reduction of venous pressure in the site of lymphatic drainage from the thoracic duct (in the junction of the left internal jugular and subclavian veins).Results. When modeling hydrodynamics under ADHF conditions on a hydrodynamic test bench, the upper venous flow through the left brachiocephalic vein was 0.4 l/min, the pressure in the site of lymphatic drainage from the thoracic duct, was decreased from 20–25 mmHg to 0–5 mmHg due to operation of the mechanized drainage device with suction/injection phase duration ratio 0.2/0.8 and pulsator pump operating frequency from 30 to 60 beats/min.
Tissue-engineered vascular patches: comparative characteristics and preclinical test results in a sheep model
Authors: Antonova L. V. , Mironov A. V. , Shabaev A. R. , Silnikov V. N. , Krivkina E. O. , Matveeva V. G. , Velikanova E. A. , Senokosova E. A. , Khanova M. Yu. , Sevostyanova V. V. , Glushkova T. V. , Mukhamadiyarov R. A. , Barbarash L. S. 
Published: December 2022

Carotid endarterectomy (CEA) with patch angioplasty is the most effective treatment for carotid artery stenosis. However, the use of existing vascular patches is often associated with thrombosis, restenosis, calcification and other complications.Objective: to develop biodegradable patches for arterial reconstruction, containing vascular endothelial growth factor (VEGF) or arginyl-glycyl-aspartic acid (RGD), and comparatively evaluate their biocompatibility and efficacy in in vitro experiments and during preclinical trials in large laboratory animal models.Materials and methods. Biodegradable patches, made from a mixture of poly(3-hydroxybutyrate-co-3- hydroxyvalerate (PHBV) and poly(ε-caprolactone) (PCL), were fabricated by electrospinning and modified with VEGF or the peptide sequence RGD in different configurations. In in vitro experiments, the surface structure, physicomechanical and hemocompatibility properties were evaluated. In in vivo experiments, we evaluated the effectiveness of the developed vascular patches for 6 months after implantation into the carotid artery of 12 sheep. The quality of remodeling was assessed using histological and immunofluorescence studies of explanted specimens.Results. The PHBV/PCL/VEGF patches had physicomechanical characteristics closer to those of native vessels and their biofunctionalization method resulted in the smallest drop in strength characteristics compared with their unmodified PHBV/PCL counterparts. Modification with RGD peptides reduced the strength of the polymer patches by a factor of 2 without affecting their stress-strain behavior. Incorporation of VEGF into polymer fibers reduced platelet aggregation upon contact with the surface of the PHBV/PCL/VEGF patches and did not increase erythrocyte hemolysis. At month 6 of implantation into the carotid artery of sheep, the PHBV/PCL/ VEGF patches formed a complete newly formed vascular tissue without signs of associated inflammation and calcification. This indicates the high efficiency of the VEGF incorporated into the patch. In contrast, the patches modified with different configurations of RGD peptides combined the presence of neointimal hyperplasia and chronic granulomatous inflammation present in the patch wall and developed during bioresorption of the polymer scaffold.Conclusion. PHBV/PCL/VEGF patches have better biocompatibility and are more suitable for vascular wall reconstruction than PHBV/PCL/RGD patches.
Steered fiber orientation: correlating orientation and residual tensile strength parameters of SFRC
Authors: Medeghini Filippo , Guhathakurta Jajnabalkya , Tiberti Giuseppe , Simon Sven , Plizzari Giovanni A. , Mark Peter 
Published: December 2022

AbstractAdding steel fibers to concrete improves the post-cracking tensile strength of the composite material due to fibers bridging the cracks. The residual performance of the material is influenced by fiber type, content and orientation with respect to the crack plane. The latter is a main issue in fiber-reinforced concrete elements, since it significantly influences the structural behavior. The aim of this research is to develop a tailor-made composite material and casting method to orient fibers in order to optimize the performance of the material for structural applications. To this aim, a mechanized concreting device that induces such preferred fiber orientation is designed and fabricated. It uses vibration and a series of narrow channels to guide and orient fibers. A composite with oriented fibers is produced using a hybrid system of macro and micro fibers and high-performance concrete. From the same concrete batch, specimens are cast both with and without the fiber orientation device, obtaining different levels of fiber orientation. Three-point bending tests are performed to measure and compare the residual tensile strength capacities with standard specimens cast according to EN 14651. Elements with favorable fiber orientation show a significant increase in residual tensile strength with respect to the standard beams. Finally, computed tomography and an electromagnetic induction method are employed to better assess the orientation and distribution of fibers in the beams. Their results are in good agreement and enable to link the residual tensile strength parameters with fiber orientation.
Yield Components and Yield Stability Performance of Some Nigerian Accessions of Bambara Groundnut [Vigna subterranea (L.) Verdc.] in Six Environments
Authors: Osundare Opeyemi T. , Akinyele Benjamin O. , Odiyi Alexander C. , Oyatomi Olaniyi A. , Abberton Michael T. 
Published: December 2022

Background: Bambara groundnut accessions over the years had been unstable in its yield potentials with contrasting yield inferences, factors not limited to variety, soil types and nutrients, climate change, time had been bottlenecks for scientist to breakthrough in stability research. Field experiments were conducted in three years at two locations to assess and identify accessions with stable yield and determine the relationship between yield and yield components. Methods: Seeds of 100 accessions of Bambara groundnut of Nigerian origin were obtained from the genebank of the Genetic Resources Center, IITA in 2017. Randomized complete block design (RCBD) was used in the evaluation for three years in two locations. PROC ANOVA procedure on the statistical analytical system (SAS, 9.4) was used to determine significant differences and stability equation was used to identify yield stable index. Result: Correlation showed that seven yield contributing traits had positive and significant correlation with yield per hectare. Yield stability analysis indicated nine of the selected accessions were stable in the expression of its yield potentials in the environments and years. This study showed that selection for high yielding and stable accessions could be useful for further utilization of genetic resources in achieving food security.
Effect of feeding broilers with the diets containing leubim fish waste meals processed with including and without its skin on the weights and percentages of carcasses and internal organs of broilers
Authors: Zulfan Zulfan , Zulfikar Zulfikar , Latif Herawati , Nyakdin Nur Ismira , Pangestu Galih Ajie 
Published: December 2022

<p class="MDPI17abstract"><strong>Objective: </strong>This study aimed to evaluate the weights and percentages of carcasses and internal organs of broilers fed the partial substituted commercial ration (CCP) with <em>leubim</em> fish waste meal (LFW) made up of whole <em>leubim</em> fish waste meal (LFW<sub>W</sub>), <em>leubim</em> fish waste skin meal (LFW<sub>S</sub>), and skinless <em>leubim</em> fish meal (LFM<sub>‒S</sub>), each combined with yellow corn (YC) + top mix (TM).</p><p class="MDPI17abstract"><strong>Methods: </strong>100 broiler chicks strain CP 707 and commercial local fish meal (CFM) were employed in this study. The study was performed into a Completely Randomized Design with subsampling comprising 5 treatments, 4 replications, and 2 subsamples. The treatment was 100% CCP (control+) and 16.5% of substituted feeds composted of the CFM (control-), the LFW<sub>W</sub>, the LFW<sub>S</sub>, the LFM<sub>‒S</sub>, with the same level of 8% each + 8% YC + 0.5% TM each. The data were analyzed by Analysis of Variance.<strong></strong></p><p class="MDPI17abstract"><strong>Results: </strong>Statistically, no significant differences (P&gt;0.05) but substitute partial commercial diet with the mixture feeds constituted of LFW meals in the forms of LFW<sub>W</sub>, LFW<sub>S</sub>, LFW<sub>‒S</sub>, each added with YC + TM had relatively higher weights of whole carcasses and cut-ups of broilers. Relatively to life weight, the carcass percentages were equal but the percentages of breasts significantly higher (P&lt;0.05) in the broilers fed the LFW-based rations. There were no significant effects (P&gt;0.05) on the weights and percentages of all internal organs.</p><p><strong>Conclusions:</strong> Substitute partial commercial ration with the<em> leubim</em> fish waste meal increased breast percentage without adverse effect on internal organs of broilers.</p>
Incidence of arrhythmias in COVID-19 patients with double mutant strain of SARS-CoV-2 virus: A tertiary care experience
Authors: Varshney Amit , Agarwal Navneet 
Published: December 2022

Background: Our understanding of arrhythmias is minimal with SARS-CoV-2 virus and with the emergence of its double mutant, virtually nonexistent. Patients with the double mutant (B.1.617) SARS-CoV infection had more cardiac manifestations, including arrhythmias and sudden death, than with the traditional variant.Objective: To determine the incidence of arrhythmias in COVID-19 patients with double mutant strain of SARS-CoV-2 virus (B.1.617).Materials and methods: We describe a prospective observational study conducted in the Department of Medicine, United Institute of Medical Sciences, Prayagraj, Uttar Pradesh on patients admitted to the hospital during the period March 2021 to May 2021. Different type of arrhythmias were studied in the admitted patients.Results: Sinus bradycardia is the most common arrhythmia, followed by atrial fibrillation. Malignant arrhythmias, such as ventricular tachycardia/ventricular fibrillation and Torsades de pointes due to QT prolongation, were present in small number of patients with high mortality outcomes. Sinus tachycardia and high-grade AV blocks were also present in some of the patients.Conclusions: Current literature lacks studies on arrhythmias secondary to COVID-19 (double mutant) strain and its possible mechanisms. This makes it difficult to distinguish between arrhythmias secondary to COVID-19 (double mutant) infection due to hypoxemia, dyselectrolytemia, SIRS, comorbidities, and medications or direct viral effects on the cardiomyocytes.
Cardiac assessment of patients during post COVID-19 recovery phase: a prospective observational study
Authors: Sharma Deepak , Rohila Amit , Deora Surender , Garg Mahendra Kumar , Misra Sanjeev 
Published: December 2022

Introduction: The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It usually presents as a respiratory syndrome but also known to cause many cardiovascular complications during acute phase. However, little is documented about cardiac complications during the post COVID-19 recovery phase. Therefore, this prospective observational study was planned to evaluate cardiovascular effects of the disease in patients recovering from COVID-19.Methods: This was a prospective observational study with a total of 63 patients presenting at 6-month follow-up in post COVID-19 outpatient clinics. Patients with known cases of underlying ischemic heart disease, cardiomyopathy, or any other cardiac disorder, and patients with chronic lung disorder or severe anemia were excluded.Results: Dyspnea was the most common presenting complaint. In biochemical parameters, none of them showed any significant difference between these two groups including NT pro BNP, ferritin, CK-MB. But NT pro BNP was high in moderate/severe cases, especially those having reduced ejection fraction. On echocardiographic evaluation, LVEF was low in moderate/severe group patients (59.7% vs. 51.1%, p<0.0001). LV diastolic dysfunction was also observed more commonly in moderate/severe group patients (55.9% vs. 86.2%, p= 0.009). There was no significant difference in RV function assessment parameters.Conclusion: Patients in the moderate/severe group during index hospitalization for COVID-19 should be followed up with NT Pro BNP and echocardiography. This may help in early recognition of heart failure during follow-up of COVID-19 patients.
Gastrointestinal bleeding during anticoagulation with direct oral anticoagulants compared to vitamin K antagonists
Authors: Dongre Kanchan , Schmid Yasmin , Nussbaum Luana , Winterhalder Clemens , Bassetti Stefano , Holbro Andreas , Degen Lukas , Leuppi-Taegtmeyer Anne B 
Published: December 2022

Aim: Patients receiving oral anticoagulants with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) have an increased risk of gastrointestinal bleeding (GIB). We compared cases of GIB associated with VKAs and DOACs in terms of risk factors, scores, timing, location, severity, and outcome.Methods: Data from patients treated at a university hospital in Switzerland for GIB under VKA and DOACs between 2012 and 2018 were analyzed in this investigator-driven, retrospective, single-center study. Results: A total of 248 patients (110 males; median age, 80 years; 134 VKA, 114 DOAC) were included. No significant differences in age, weight or sex were observed. The propensity of the VKA group for risk factors such as comorbidities, interacting medications, or a high risk for bleeding (HAS-BLED score) was higher than that of the DOAC group. 56% of the VKA-treated patients had a supratherapeutic INR, and 25% in the DOAC group received an unlicensed dose. Significantly more patients in the DOAC group were not formally overdosed with OAC whilst receiving amiodarone compared to the VKA group (57% vs. 18%, respectively, p = 0.03). Latency between the documented start of oral anticoagulation and GIB was shorter in the DOAC group (median 3 months) than in the VKA group (median 23.5 months, p<0.001). There were no differences in terms of location and severity of the GIB, length of hospitalization, or mortality. Conclusion: Patients taking VKAs displayed more risk factors for GIB than those taking DOACs. Treatment with DOACs was associated with early GIB and calls for increased vigilance during the first months after commencement. Co-medication with amiodarone appeared to be a risk factor for GIB in patients taking DOACs.
Infección urinaria de presentación atípica: caso clínico y revisión de literatura
Authors: Buitrago Rojas M. Carolina , Rozo Ortiz Edwar J. , Vargas Rodríguez Ledmar J. , Acosta Pérez Camila Andrea , Pacheco Olmos Blanka Stefany , Pinilla Vivas Lucas Mateo 
Published: December 2022

Introducción: el síndrome de orina púrpura es una presentación clínica poco frecuente en el ámbito de urgencias, caracterizado por coloración anormal de la orina secundaria a una reacción química de algunos patógenos que producen infección de vías urinarias, siendo más frecuente en pacientes con múltiples comorbilidades y diferentes factores de riesgo.
Objetivo: el objetivo de este manuscrito es presentar el caso de un paciente con síntomas atípicos de infección de vías urinarias.
Presentación del caso: varón de 88 años de edad, con antecedente de diabetes mellitus no insulino-requiriente, con hiperplasia prostática benigna que ingresó al servicio de urgencias por síntomas irritativos urinarios asociados a uso de sonda vesical, con orina de coloración violeta en bolsa recolectora. El urocultivo reportó la presencia de Proteus vulgaris multisensible, por lo que se decidió dar manejo con cefepima de 1 gr cada ocho horas, con lo cual se obtuvo una adecuada evolución clínica.
Discusión y conclusión: el síndrome de la bolsa de orina púrpura es una presentación clínica atípica, pero muy llamativa de la infección urinaria. Esta se genera como resultado de la conversión del triptófano en la dieta en indoxil sulfato que, una vez se elimina por la orina, se transforma en índigo (color violeta) e indirrubina (color rojo), dando este aspecto clínico.
Project Based Learning (PjBL) Model Integration of Sasak Ethnic Nenun Local Wisdom in Sociology Subjects
Authors: Noviana Mila , Komariah Siti 
Published: December 2022

The PjBL model with the unification of Sasak ethnic nenun local wisdom in Sociology subjects with the nenun topic and social deviation at least gives students a new nuance in learning Sociology so that students are more motivated and have high enthusiasm in learning. The purpose of this study was to integrate the PjBL model with the Sasak ethnic nenun local wisdom in the subject of Sociology. This study used a literature review method, by trying to develop a PjBL learning model that is reviewed from various relevant references. The results of the research was the PjBL model of integrating Sasak ethnic nenun local wisdom in Sociology subjects which can be the basis for educational practice to realize independence, entrepreneurship, responsibility, perseverance, and thoroughness. With the application of local wisdom, it is also able to cultivate the spirit of student learning enthusiasm and students know their own wisdom which is full of good values, empowerment, especially in social and economic aspects, leadership, simplicity, social interaction, hard work, life advice. Added by combining the social media such as Instagram and Tiktok, these are very familiar to students so that it will also affect the Sociology learning process.
Thermal De-Oxygenation to Form Condensable Aerosol From Reconstituted Tobacco without Auto-Ignition
Authors: Guo Zhongya , Wang Shiyu , Zhang Ke , Lei Ping , Fu Lili , Zhang Qi , Shang Shanzhai , Wang Shuang , Wang Le , Zhang Mingjian , Gong Weimin , Han Jingmei , Li Zhiqiang , Pan Yonghua , Huang Feng , Liu Chuan , Tang Jianguo , Wang Bing , Li Bin 
Published: December 2022

Summary
A novel concept is described here that utilizes externally applied heat to a solid rod of reconstituted tobacco biomass to form a stream of aerosol under progressively oxygen-deficient atmosphere. The boundary of auto-ignition was determined at oxygen concentrations of 0%, 5%, 10%, and 21% and then the effects of these different atmospheres on various parameters were studied. Experimental results indicated that the ignition temperature decreased with the increase of oxygen concentration and a negative temperature coefficient (NTC) for atmosphere with oxygen was observed at before but close to ignition temperature. Significant differences in the yields of CO and CO2 between oxygen and oxygen-free atmosphere were observed. The mass of aerosol produced under an inert atmosphere and reduced-oxygen atmosphere were characterized with selected volatile and semi-volatile components, phenols, aldehydes, and other organic compounds of interests. In addition, higher oxygen concentration resulted in higher bulk and surface oxygen content of solid-phase residue, the reduction of carbon and hydrogen element content and related functional groups, and the content of inorganic compounds also exhibited an increase with oxygen concentration. By systematically changing oxygen concentrations of the biomass bed with increasing temperatures, an aerosol stream of controlled chemical composition and yields could be formed without leading to ignition. Key chemical markers of inhalation harm were measured and compared to each other under different degrees close to combustion. Studying reconstituted tobacco or other biomass materials in such a way could provide alternative and useful information in the design heated biomass aerosol generators.