bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Penanganan Nyeri Haid (Dysmenorrhea) Dengan Protection Motivation Theory
Authors: Haditya Tasya , Mardlatillah Mardlatillah , Ain Farah Nur , Syifa Nur , Fadhli Muhammad Akhzani 
Published: December 2022

Latar belakang: Menstruasi yang dikenal dengan nama haid atau datang bulan merupakan perubahan fisiologis dalam perempuan yang terjadi secara berkala dan dipengaruhi oleh hormon reproduksi, yang dimulai dari menarche sampai menopouse. Kelainan atau gangguan yang ada hubungan dengan menstruasi diantaranya premenstrual tension (ketegangan sebelum haid), mastodinia (rasa nyeri pada payudara), mittelschmerz (rasa nyeri saat ovulasi), dan dysmenorrhea (rasa nyeri saat menstruasi). Nyeri haid (dysmenorrhea) adalah salah satu kelainan yang menyebabkan perempuan muda pergi ke dokter untuk berkonsultasi dan berobat. Nyeri haid atau disebut Dysmenorrhea adalah nyeri yang biasanya timbul pada masa remaja, yaitu sekitar 2 sampai 3 tahun setelah menstruasi pertama. Nyeri haid merupakan keluhan yang sering dialami remaja pada bagian perut bawah (Kusmiran, 2013). Nyeri haid membuat perempuan tidak bisa beraktivitas secara normal dan memerlukan resep obat. Keadaan tersebut menyebabkan menurunnya kualitas hidup perempuan, sebagai contoh mahasiswi yang mengalami nyeri haid primer tidak dapat berkonsentasi dalam belajar dan motivasi belajar menurun karena nyeri yang dirasakan.
Tujuan: Untuk melihat serta mengevaluasi perilaku pada penderita nyeri haid (dysmenorrhea) dalam melakukan perilaku protektif (protection motivation theory).
Metode: Penelitian yang bersifat evaluatif yang bertujuan untuk melihat kerasionalan penanganan nyeri haid (dysmenorrhea) pada mahasiswi Fakultas Kesehatan Universitas Sari Mulia Banjarmasin. Pendekatan yang digunakan pada desain penelitian ini adalah cross sectional study dimana data dikumpulkan pada satu waktu tertentu. Pengambilan data dilakukan di Fakultas Kesehatan Universitas Sari Mulia Banjarmasin pada bulan April-Mei 2021.
Hasil: Pada project kali ini telah dilakukan riset terhadap Evaluasi Penanganan Nyeri Haid (Dysmenorrhea) dengan Protection Motivation Theory. Kami menyebarkan 21 pertanyaan dan mendapatkan 80 responden dari berbagai jurusan dan semester yang ada di fakultas kesehatan, yaitu 51,2% mahasiswi farmasi, 28,7% mahasiswi keperawatan, 13,7% mahasiswi kebidanan dan 6,3% mahasiswi promosi kesehatan. Dari 80 responden tersebut pula terdiri atas 52,5% mahasiwi semester 4, 31,3% mahasiswi semester 2, 12,5% mahasiswi semeter 6 dan 3,7% mahasiswi semester 8. Rentang usia responden ialah berkisar antara 18-22 tahun.

Kesimpulan: Responden melakukan usaha perlindungan diri dari nyeri haid (dysmenorrhea) yang dirasakan dengan cara melakukan terapi, baik secara farmakologi dan non farmakologi. Responden berusaha untuk melakukan pengobatan yang rasional seperti penggunaan dosis yang tepat, frekuensi, dan cara pakai yang tepat.
Pengaruh Budaya Terhadap Penggunaan TOGA (Tanaman Obat Keluarga) Di Masyarakat Desa Terombongsari
Authors: Shofia Diah Vinalisa Hasna , Yuwindry Iwan , Rahman Faisal 
Published: December 2022

Latar Belakang: Masyarakat Desa Terombongsari sangat banyak yang menggunakan TOGA (Tanaman Obat Keluarga) sebagai terapi secara mandiri. Masyarakat disana cenderung lebih memilih TOGA dibandingkan pengobatan secara sintetis selain minim efek samping, TOGA juga mudah didapatkan dipekarangan rumah masyarakat. Masyarakat memutuskan melakukan pengobatan mandiri dipengaruhi oleh beberapa faktor, salah satunya yaitu budaya. Budaya diartikan sebagai kebiasaan secara turun temurun yang terjadi di masyarakat Desa Terombongsari.
Tujuan: Penelitian ini bertujuan menganalisis pengaruh budaya terhadap penggunaan TOGA di masyarakat Desa Terombongsari.
Metode: Penelitian ini menggunakan jenis penelitian Observasional Analitik dengan desain penelitian cross sectional. Sampelnya yaitu masyarakat dewasa usia minimal 17 tahun yang berjumlah 92 KK yang rutin menggunakan TOGA. Pemilihan sampel dengan metode purposive sampling. Pengumpulan data dengan lembar kuesioner, data dianalisis menggunakan uji Kendall tau-b dengan tingkat kepercayaan 95%.
Hasil: Hasil menunjukan sebanyak 79,3% budaya penggunaan TOGA yang ada dimasyarakat Desa Terombongsari bernilai positif. Hasil dalam penggunaan TOGA masuk kategori baik sebanyak 90,2%. Hasil analisis bivariat diperoleh nilai p – value yaitu 0,0001 yang artinya Ha di terima.
Simpulan: Terdapat pengaruh budaya terhadap penggunaan TOGA di masyarakat Desa Terombongsari.
Pendekatan Health Belief Model (HBM) Untuk Menganalisis Kepatuhan Pasien Diabetes Mellitus Dalam Menggunakan Insulin Di Kota Banjarmasin
Authors: Sariyasih Sariyasih , Yuwindry Iwan , Syamsu Erlina 
Published: December 2022

Latar Belakang: Health Belief Model (HBM) merupakan teori yang digunakan untuk memahami sikap serta prilaku kesehatan terhadap suatu penyakit, hbm terdiri faktor persepsi kerentanan, persepsi keparahan, persepsi manfaat, persepsi hambatan, dan pemicu untuk bergerak. Upaya pencegahan penyebaran virus covid-19 di Indonesia dilakukan dengan menetapkan peraturan untuk melakukan vaksinasi covid-19 terutama pada lansia yang rentan terinfeksi dengan cakupan vaksinasi sebesar 70% untuk mencapai Herd Immunity.
Tujuan: Mengetahui faktor persepsi kerentanan, persepsi keparahan, persepsi manfaat, dan persepsi hambatan dalam mempengaruhi persepsi lansia terhadap penerimaan vaksinasi covid-19 di Kabupaten Tanah Bumbu.
Metode: Penelitian ini merupakan cross sectionaldengan jenis penelitian yang digunakan adalah kuantitatif. Metode pengambilan sampel dengan teknik purposive sampling dan instrument yang digunakan pada penelitian adalah kuesioner dengan google form. Analisis data yang digunakan adalah Univariat, Bivariat dengan Chi Square, dan Multivariat dengan regresi logistic.
Hasil: Penelitian menunjukkan dari 120 responden lansia di Kabupaten Tanah Bumbu didapatkan sebanyak 65.8% lansia menyatakan akan melakukan vaksinasi covid-19. Faktor yang dominan dalam mempengaruhi vaksinasi adalah persepsi hambatan yaitu khawatir kemungkinan terjadi infeksi dalam waktu dekat yang tinggi. Faktor persepsi kerentanan, keparahan, manfaat dan hambatan memiliki pengaruh dengan penerimaan vaksinasi pada lansia di Tanah Bumbu. Faktor demografis (usia, jenis kelamin, pekerjaan, pendidikan, agama, pernah atau tidaknya didiagnosis penyakit kronis) tidak memiliki pengaruhyang signifikan dengan penerimaan vaksin covid-19 di Kabupaten Tanah Bumbu.
Simpulan: 65.8% lansia di Tanah Bumbu menyatakan akan melakukan vaksinasi covid-19. Persepsi hambatan, manfaat, kerentanan, keparahan, dan pemicu untuk bergerak memiliki pengaruh terhadap penerimaan vaksinasi covid-19.
Penurunan Kadar Logam Timbal (Pb) Pada Daging Ikan Kelabau (Osteochilus melanopleurus) Dengan Filtrat Asam Jawa (Tamarindus indica)
Authors: Rachman Felix Imanuel , Rahmadani Rahmadani , Rizal Muhammad 
Published: December 2022

Latar belakang: Asam jawa memiliki asam sitrat yang memiliki kemampuan mereduksi cemaran logam berat. Asam sitrat dengan gugus trikarboksilatnya dapat mengikat dengan logam berat dan menghasilkan ion kompleks serta memiliki sifat yang stabil berupa khelat.
Tujuan: Melihat pengaruh asam jawa terhadap logam berat timbal serta hubungan antara variasi konsentrasi asam jawa dengan penurunan kadar logam berat timbal pada daging ikan.
Metode: Penelitian ini menggunakan metode pra-eksperimental dengan pendekatan only-posttest design dengan menggunakan instrumen spektrofotometri serapan atom (SSA).
Hasil: Berdasarkan penelitian yang telah dilakukan, didapatkan penurunan kadar logam hasil perlakuan dengan asam jawa 5% adalah 63,923%, asam jawa 10% adalah 41,431%, dan asam jawa 10% adalah 26,484% dengan hasil signifikansi sebesar 0,715.
Kesimpulan: Berdasarkan hasil penelitian, didapatkan bahwa tidak adanya hubungan antara variasi konsentrasi asam jawa dengan kadar timbal.
Construction of a prognostic assessment model for colon cancer patients based on immune-related genes and exploration of related immune characteristics
Authors: Wan Yanhua , He Yingcheng , Yang Qijun , Cheng Yunqi , Li Yuqiu , Zhang Xue , Zhang Wenyige , Dai Hua , Yu Yanqing , Li Taiyuan , Xiong Zhenfang , Wan Hongping 
Published: December 2022

Objectives: To establish a novel risk score model that could predict the survival and immune response of patients with colon cancer.Methods: We used The Cancer Genome Atlas (TCGA) database to get mRNA expression profile data, corresponding clinical information and somatic mutation data of patients with colon cancer. Limma R software package and univariate Cox regression were performed to screen out immune-related prognostic genes. GO (Gene ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) were used for gene function enrichment analysis. The risk scoring model was established by Lasso regression and multivariate Cox regression. CIBERSORT was conducted to estimate 22 types of tumor-infiltrating immune cells and immune cell functions in tumors. Correlation analysis was used to demonstrate the relationship between the risk score and immune escape potential.Results: 679 immune-related genes were selected from 7846 differentially expressed genes (DEGs). GO and KEGG analysis found that immune-related DEGs were mainly enriched in immune response, complement activation, cytokine-cytokine receptor interaction and so on. Finally, we established a 3 immune-related genes risk scoring model, which was the accurate independent predictor of overall survival (OS) in colon cancer. Correlation analysis indicated that there were significant differences in T cell exclusion potential in low-risk and high-risk groups.Conclusion: The immune-related gene risk scoring model could contribute to predicting the clinical outcome of patients with colon cancer.
Impact of diastolic pulmonary gradient and pulmonary artery pulse index on outcomes in heart transplant patients—Results from the Eurotransplant database
Authors: Wagner Tobias , Magnussen Christina , Bernhardt Alexander , Smits Jacqueline M. , Steinbach Katrin , Reichenspurner Hermann , Kirchhof Paulus , Grahn Hanno 
Published: December 2022

BackgroundPredicting complications associated with pulmonary hypertension (PH) after cardiac transplantation is an important factor when considering cardiac transplantation. The transpulmonary gradient (TPG) is recommended to quantify PH in transplant candidates. Nonetheless, PH remains a common driver of mortality. The diastolic pressure gradient (DPG) and pulmonary vascular resistance (PVR) can differentiate post- from combined pre- and post-capillary PH and may improve estimation of PH-associated risks. We used a large European cohort of transplant candidates to assess whether the pulmonary pulsatility index (PAPi), improves prediction of graft failure and mortality compared to DPG and PVR.MethodsOut of all patients undergoing heart transplantation between 2009 and 2019 in Eurotransplant member states (n = 10,465), we analyzed the impact of PH (mPAP &gt; 25 mmHg) and right heart catheter hemodynamic data on graft failure and mortality within 1–5 years.ResultsIn 1,407 heart transplant patients with PH (79% male, median age 54 years, IQR 39–69 years), the median PVR was 2.5 WU (IQR 1.6 WU) with a median mPAP (pulmonary arterial pressure) of 32 mmHg (IQR 9 mmHg). Patients with low (&lt; 3 mmHg) DPG had a better 5 year survival than those with higher DPG (log rank p = 0.023). TPG, mPAP, PAPi, and PVR did not improve prediction of survival. Low PAPi (OR = 2.24, p &lt; 0.001) and high PVR (OR = 2.12, p = 0.005) were associated with graft failure.ConclusionPAPI and PVR are associated with graft failure in patients with PH undergoing cardiac transplantation. DPG is associated with survival in this cohort.
Clinical observation of sacubitril valsartan sodium in the treatment of resistant hypertension: A randomized clinical trial
Authors: Lyu Tian-Jiao , Liu Ying , Zhang Hong , Li Ling-Yan , He Rui-Qing , Gao Jun-Qing , Liu Zong-Jun 
Published: December 2022

ObjectiveTo investigate the effectiveness and safety of sacubitril valsartan sodium in the treatment of resistant hypertension (RH).MethodsThis study is a single-center, prospective, randomized controlled study. According to the inclusion and exclusion criteria, patients with RH who met the criteria were screened, and all patients adjusted their drug treatment (valsartan 80 mg, amlodipine 5 mg, and hydrochlorothiazide 12.5 mg). After 4 weeks of drug elution, the random envelope method was used for random grouping. The treatment group took sacubitril valsartan sodium 200 mg, amlodipine 5 mg, hydrochlorothiazide 12.5 mg, and the control group took valsartan 80 mg, amlodipine 5 mg, and hydrochlorothiazide 12.5 mg for 8 weeks. The 24 h ambulatory blood pressure (BP) and the echocardiography index using the office sphygmomanometer were observed in the patients.ResultsA total of 100 patients with RH were included in the two groups, with 50 cases in each group. There were no significant differences in sex, age, or comorbid diseases between the two groups. During the 8-week follow-up, the office BP of the research group were significantly decreased (24.78/17.86 mmHg) compared with those of the control group. In the research group the 24 h average BP, daytime average BP, and nighttime average BP were 144.84/79.82, 147.10/82.06, and 138.67/76.31 mmHg at baseline, and reduced to 128.96/73.32, 131.50/74.94, and 122.11/69.27 mmHg at week 8, which were significantly decreased (P &lt; 0.05 or P &lt; 0.01), and the left ventricular ejection fraction was significantly increased (P &lt; 0.05), compared with the control group.ConclusionSacubitril valsartan sodium can effectively reduce BP and improve cardiac function in RH.
Predictive nomogram model for major adverse kidney events within 30 days in sepsis patients with type 2 diabetes mellitus
Authors: Xin Qi , Xie Tonghui , Chen Rui , Wang Hai , Zhang Xing , Wang Shufeng , Liu Chang , Zhang Jingyao 
Published: December 2022

BackgroundIn sepsis patients, Type 2 Diabetes Mellitus (T2DM) was associated with an increased risk of kidney injury. Furthermore, kidney damage is among the dangerous complications, with a high mortality rate in sepsis patients. However, the underlying predictive model on the prediction of major adverse kidney events within 30 days (MAKE30) in sepsis patients with T2DM has not been reported by any study.MethodsA total of 406 sepsis patients with T2DM were retrospectively enrolled and divided into a non-MAKE30 group (261 cases) and a MAKE30 group (145 cases). In sepsis patients with T2DM, univariate and multivariate logistic regression analyses were conducted to identify independent predictors of MAKE30. Based on the findings of multivariate logistic regression analysis, the corresponding nomogram was constructed. The nomogram was evaluated using the calibration curve, Receiver Operating Characteristic (ROC) curve, and decision curve analysis. A composite of death, new Renal Replacement Therapy (RRT), or Persistent Renal Dysfunction (PRD) comprised MAKE30. Finally, subgroup analyses of the nomogram for 30-day mortality, new RRT, and PRD were performed.ResultsIn sepsis patients with T2DM, Mean Arterial Pressure (MAP), Platelet (PLT), cystatin C, High-Density Lipoprotein (HDL), and apolipoprotein E (apoE) were independent predictors for MAKE30. According to the ROC curve, calibration curve, and decision curve analysis, the nomogram model based on those predictors had satisfactory discrimination (AUC = 0.916), good calibration, and clinical application. Additionally, in sepsis patients with T2DM, the nomogram model exhibited a high ability to predict the occurrence of 30-day mortality (AUC = 0.822), new RRT (AUC = 0.874), and PRD (AUC = 0.801).ConclusionThe nomogram model, which is available within 24 hours after admission, had a robust and accurate assessment for the MAKE30 occurrence, and it provided information to better manage sepsis patients with T2DM.
Triglyceride to high-density lipoprotein cholesterol ratio is an independent predictor of liver fibrosis among pediatrics non-alcoholic fatty liver disease
Authors: Ting Yi-Wen , Jalaludin Muhammad Yazid , Zaini Azriyanti Anuar , Mohamed Rosmawati 
Published: December 2022

BackgroundInsulin resistance (IR), one of the key components of the metabolic syndrome, is recognized as the pathophysiological hallmark of non-alcoholic fatty liver disease (NAFLD). This study aims to investigate the relationship between surrogate markers of IR and the severity of NAFLD among overweight or obese children.MethodologyA total of 56 consecutive children aged 6 to 18 years old were recruited from the pediatric obesity and type 2 diabetes mellitus (T2DM) clinic in University Malaya Medical Centre (UMMC) from 2016 to 2019. Data on anthropometric measurements, clinical components of metabolic syndrome and fasting serum insulin were collected. Triglyceride to high-density lipoprotein cholesterol ratio (TG: HDL-C), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Single Point Insulin Sensitivity Estimator (SPISE) were calculated. Transient elastography was performed with hepatic steatosis and liver fibrosis assessed by controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), respectively.ResultsA total of 44 children (78.6%) had liver steatosis and 35.7% had presence of significant liver fibrosis (stage F≥2). Majority (89.3%) are obese and 24 children (42.9%) were diagnosed with metabolic syndrome. Higher number of children with T2DM and significant liver fibrosis were associated with higher tertiles of TG: HDL-C ratio (p&lt;0.05). Top tertile of TG: HDL-C ratio was an independent predictor of liver fibrosis (OR=8.14, 95%CI: 1.24–53.36, p=0.029). ROC analysis showed that the area under the curve (AUC) of HOMA-IR (0.77) and TG: HDL-C ratio (0.71) were greater than that of metabolic syndrome (0.70), T2DM (0.62) and SPISE (0.22). The optimal cut-off values of HOMA-IR and TG: HDL-C ratio for detecting liver fibrosis among children with NAFLD are 5.20 and 1.58, respectively.ConclusionChildren with NAFLD and higher TG: HDL-C ratio are more likely to have liver fibrosis. TG: HDL-C ratio is a promising tool to risk stratify those with NAFLD who are at risk of developing advanced liver disease.
siAKR1C3@PPA complex nucleic acid nanoparticles inhibit castration-resistant prostate cancer in vitro
Authors: Cui Xiaoli , Yao Zhou , Zhao Tianyu , Guo Jiahui , Ding Jipeng , Zhang Siwei , Liang Zuowen , Wei Zhengren , Zoa Alexis , Tian Yuantong , Li Jing 
Published: December 2022

IntroductionAKR1C3, as a crucial androgenic enzyme, implicates the androgen biosynthesis and promoting prostate cancer cell growth in vitro. This study provides a new gene therapy strategy for targeting AKR1C3 to treat castration-resistant prostate cancer.MethodssiAKR1C3@PPA is assembled from PEG3500, PAMAM, Aptamer-PSMA, and siRNA for AKR1C3. We analyzed the relationship between AKR1C3 expression and the survival rate of prostate cancer patients based on the GEPIA online database to perform disease-free survival, and found that AKR1C3 may be an important factor leading to poor prognosis in prostate cancer. Considering AKR1C3 as a therapeutic target for castration-resistant prostate cancer, we constructed a complex nucleic acid nanoparticle, siAKR1C3@PPA to investigate the inhibitory effect on castration-resistant prostate cancer.ResultsAptamer-PSMA acts as a target to guide siAKR1C3@PPA into PSMA-positive prostate cancer cells and specifically down regulate AKR1C3. Cyclin D1 was decreased as a result of siAKR1C3@PPA treatment. Changes in Cyclin D1 were consistent with decreased expression of AKR1C3 in LNCaP-AKR1C3 cells and 22RV1 cells. Furthermore, in the LNCaP-AKR1C3 group, 1070 proteins were upregulated and 1015 proteins were downregulated compared to the LNCaP group according to quantitative 4D label-free proteomics. We found 42 proteins involved in cell cycle regulation. In a validated experiment, we demonstrated that PCNP and CINP were up-regulated, and TERF2 and TP53 were down-regulated by western blotting.ConclusionWe concluded that siAKR1C3@PPA may arrest the cell cycle and affect cell proliferation.
m6A regulators featured by tumor immune microenvironment landscapes and correlated with immunotherapy in non-small cell lung cancer (NSCLC)
Authors: Yuan Baowen , Qin Hao , Zhang Jingyao , Zhang Min , Yang Yunkai , Teng Xu , Yu Hefen , Huang Wei , Wang Yan 
Published: December 2022

IntroductionRecent research has confirmed the critical role that epigenetic factors play in regulating the immune response. Nonetheless, what role m6A methylation modification might play in the immune response of non-small cell lung cancer (NSCLC) remains vague.MethodsHerein, the gene expression, copy number variations (CNVs), and somatic mutations of 31 m6A regulators in NSCLC and adjacent control samples from the GEO and TCGA databases were comprehensively explored. Using consensus clustering, m6A modification patterns were identified. Correlations between m6A modification patterns and immune cell infiltration traits in the tumor immune microenvironment (TME) were systematically analyzed. Differentially expressed genes were verified and screened by random forest and cox regression analysis by comparing different m6A modification patterns. Based on the retained gene panel, a risk model was built, and m6Ascore for each sample was calculated. The function of m6Ascore in NSCLC prognosis, tumor somatic mutations, and chemotherapy/immunotherapy response prediction were evaluated.ResultsConsensus clustering classified all NSCLC samples into two m6A clusters (m6A_clusterA and m6A_clusterB) according to the expression levels of 25 m6A regulator genes. Hierarchical clustering further divides the NSCLC samples into two m6A gene clusters: m6AgeneclusterA and m6AgeneclusterB. A panel of 83 genes was screened from the 194 differentially expressed genes between m6A gene clusters. Based on this, a risk score model was established. m6A modification clusters, m6A gene clusters, and m6Ascore calculated from the risk model were able to predict tumor stages, immune cell infiltration, clinical prognosis, and tumor somatic mutations. NSCLC patients with high m6Ascore have poor drug resistance to chemotherapy drugs (Cisplatin and Gemcitabine) and exhibit considerable therapeutic benefits and favorable clinical responses to anti-PD1 or anti-CTLA4 immunotherapy.DiscussionIn conclusion, methylation modification patterns mediated by the m6A regulators in individuals play a non-negligible role in prognosis prediction and immunotherapy response, which will facilitate personalized treatment and immunotherapeutic strategies for NSCLC patients in the future.