bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Hematological Parameters with Nottingham Histologic Grades of Breast Carcinoma in South Indian Population
Authors: Chander U. Sunderesh Kamal , Vanishree M. , Sulochana Sonti , Rowland Marlina 
Published: June 2022

Aim: To determine the most reliable hematological markers for the prognosis of breast cancer. To evaluate the correlation between hematological parameters and histopathological grading.
Study Design: A retrospective study
Place of Study: This study was carried out in Saveetha Medical College and Hospital, Tamil Nadu, India.
Methodology: Study was started after obtaining the approval from the ethics committee. Histopathological grades 1, 2 and 3 of breast cancer patients were correlated with their hematological parameters.
Results: Out of 104 cases of breast carcinoma, maximum of cases were seen in histopathological grade 2, followed by grade 3 and grade 1 respectively. On correlation with hematological parameters, Hb concentration, RBC count, PCV , MCV , TLC , DLC(neutrophil, lymphocytes) and Absolute lymphocyte count was decreased as the grade increase. RDW increased with higher the grade. Neutrophil lymphocytes ratio showed statistically increased increase in histopathological grade 3 when compared to grade 1.
Conclusion: Our study showed that the hematological parameters like hemoglobin, RBC count, PCV, WBC count, platelet count, absolute neutrophil count, absolute lymphocyte count, NLR in breast cancer can be a useful guide for disease progression.
Cone-Beam Computed Tomography versus Rendered Panoramic Images in Determination of Dens Invaginatus Characteristics: Retrospective Cohort Study
Authors: Al-Mutairi Leena Mekhled , Khan Asma Munir 
Published: June 2022

Background: "Dens in Dente" is another name for Dens invaginatus. It's an uncommon developmental aberration that comes in a range of shapes and sizes. Invagination begins in the crown and may go to the root. The goal of this study was to use CBCT and panoramic pictures created from CBCT scans to evaluate the existence, kind, and features of DI in full-mouth surveys in Saudi patients presenting to Qassim dental college, and to compare the findings of the imaging modalities.
Methods: This retrospective cohort study was performed by using 302 previously obtained CBCT records of patients from the database of the oral and maxillofacial radiology department of Qassim University, Saudi Arabia from yer 2016 to 2021. The research was ethically approved by the ethical approval committee of Qassim university (Code #: F-2019-3005).
Results: In the present study, the age of the patients ranged from 9 to 80 years (mean age was 44 years). Out of 302 scans, 153 patients were female, and 149 were found to be male. According to the Cohen kappa test, the inter-examiner agreement was high between the 2 assessments of the observers: k = 0.795, P < .000 for CBCT and k = 0.915, P < .000 for panoramic images rendered from CBCT images. On the basis of the CBCT images, DI was observed in 98 of the 302 patients (frequency, 32.5%). Type I DI was the most commonly observed type of invaginatus (93.9%), followed by type II (6.1%). However, type III was not being observed.
Conclusion: We can deduce that there is no special relationship between gender and the presence of dens invagnatus. When it comes to diagnosing and classifying dens invaginatus, CBCT images outperform rendered panoramic images. Because it provides an accurate representation of the external and internal dental anatomy, as well as appropriate visualization of associated characteristics with such cases that would be absolutely necessary in their treatment phases, CBCT can be recommended as an effective diagnostic device for identifying DI.
Injectable Reactive Oxygen Species‐Responsive Hydrogel Dressing with Sustained Nitric Oxide Release for Bacterial Ablation and Wound Healing
Authors: Yu Jie , Zhang Ruili , Chen Baihang , Liu Xuelan , Jia Qian , Wang Xiaofei , Yang Zuo , Ning Pengbo , Wang Zhongliang , Yang Yang 
Published: June 2022

AbstractSkin wound healing strategies that promote sustainable healing, prevent bacterial infections, and cause only mild irritation are urgently needed for open wound therapy. In this study, a system that consists of a reactive oxygen species (ROS)‐degradable hydrogel dressing, with encapsulated biosafe nitric oxide (NO) donor L‐arginine (L‐Arg), and a low level (100 × 10−6 m) of the household disinfectant hydrogen peroxide (H2O2) is established for sustainable wound therapy and disinfection. Under stimulation with a low level of H2O2, NO is sustainably generated from L‐Arg within the hydrogel dressing, which mediates macrophage and fibroblast chemotaxis to the wound site, as well as collagen synthesis, resulting in rapid wound healing and skin organ regeneration. The combination of H2O2 and NO also endows the system with a synergistic antibacterial ability to eliminate ampicillin‐resistant Escherichia coli. In addition, a full‐thickness skin wound model demonstrates that the ROS‐degradable hydrogel dressing, with a wound exudate adsorption ability, shows effective wound healing promotion and a good biocompatibility, without any hazardous residues and skin irritation. This ROS‐responsive, degradable, synergistic wound healing system provides an alternative strategy for sustainable wound treatment, both at home and in the clinic.
Remarkable Magnetic Exchange Coupling via Constructing Bi‐Magnetic Interface for Broadband Lower‐Frequency Microwave Absorption
Authors: Yuan Mingyue , Zhao Biao , Yang Chendi , Pei Ke , Wang Longyuan , Zhang Ruixuan , You Wenbin , Liu Xianhu , Zhang Xuefeng , Che Renchao 
Published: June 2022

AbstractSevere lower‐frequency (2–8 GHz) microwave pollution caused by the rapid development of 5th generation (5G) communication posts significance on cutting‐edge microwave absorbers. However, the intensely coupled wave‐impedance and microwave dissipating ability dramatically hinder their performance in the exact lower‐frequency range. The rationally designed heterostructure of hard/soft ferrite composite provides an efficient solution to address the issue. In this context, core‐shell structured hard/soft BaFe(12‐x)CoxO19@Fe3O4 with abundant heterointerface is created using facile spray‐drying and subsequent solvothermal approach, where hard magnetic BaFe(12‐x)CoxO19 serves as the core and soft magnetic Fe3O4 serves as the shell, respectively. The unique core‐shell integration contributes sufficient magnetic exchange coupling interaction for strong magnetic loss beyond Snoek's limitation, which considerably boosts a lower‐frequency microwave absorption. Accordingly, the minimum reflection loss (RLmin) of typical BaFe11.6Co0.4O19@Fe3O4 microcomposite reaches −48.9 dB at the thickness of 3.5 mm, its bandwidth of reflection loss < −10 dB can cover almost all the S and C bands (2.6–8 GHz). Generally, an easy and controllable pathway is conveyed in this work to encourage improved magnetic loss ability as well as decouple the wave‐impedance and microwave dissipating ability in magnetic composites, which widens the road to the development of advanced lower‐frequency magnetic absorbers.
Self‐Organized Small Molecules in Robust MOFs for High‐Performance Perovskite Solar Cells with Enhanced Degradation Activation Energy
Authors: Wang Jiaqi , Zhang Jian , Gai Shuang , Wang Wei , Dong Yayu , Hu Boyuan , Li Jiao , Lin Kaifeng , Xia Debin , Fan Ruiqing , Yang Yulin 
Published: June 2022

AbstractA brand new strategy to improve the volatility and disordered arrangement of small organic molecule additives within doped perovskite solar cells through the construction of metal–organic frameworks (MOFs) is proposed. The Zn‐TTB, self‐assembling from Zn2+ and 1‐(triazol‐1‐ly)‐4‐tetrazol‐5‐ylmethyl)benzene (TTB), inherits and arranges triazole and tetrazole groups and forms a long‐chain structure surrounding metal nodes. The perovskite precursors grow along with the skeleton of Zn‐TTB and produce a macromolecular intermediate phase via the MOFs‐perovskite interconnection, subsequently forming superior perovskite films with enhanced stability with respect to molecular additives, as evidenced by in situ thermogravimetry‐Fourier transform infrared spectroscopy measurements. Thermal analyses suggest MOF‐doping increases degradation activation energies by up to >174.01 kJ mol–1 compared to the reference sample (162.45 kJ mol–1). Zn‐TTB‐modified devices exhibit promising efficiencies (up to 23.14%) and operational stability in unencapsulated state, even under constant solar light illumination.
Photonic Barcodes Combining Branched Hybridization Chain Reaction for Multiplex Quantification of Bladder Cancer MicroRNAs
Authors: Wei Xiaowei , Cai Zehan , Cai Lijun , Wang Yu , Zhang Dagan , Zhu Yefei 
Published: June 2022

AbstractBladder cancer is the most common malignant tumor of the urinary system with substantial therapy cost and mortality. Recently, quantification and multiplex detection of circulating microRNAs (miRNAs) from human serum has opened a new avenue for efficient diagnosis of bladder cancer. Herein, a novel multiplex platform is designed toward bladder cancer‐related miRNAs detection by integrating photonic crystal (PhC) barcodes with the branched hybridization chain reaction (B‐HCR). PhC barcodes possess constant characteristic reflection peaks originating from the highly ordered microstructure and thus exhibit vivid structural colors as the encoding elements. B‐HCR is an isothermal enzyme‐free amplification strategy on the basis of hybridization chain reaction (HCR), which presents a higher amplification efficiency. By integrating the vivid structural colors of PhC barcodes with the isothermal amplification of B‐HCR, this platform shows an acceptable accuracy, reproducibility, and high sensitivity for multiplex detection of low‐abundance miRNAs. Moreover, the results are consistent with conventional qRT‐PCR in the serum specimens. Therefore, this platform may provide a new approach for the clinical diagnosis of bladder cancer.
Mixed Solvents Assisted Post‐Treatment Enables High‐Efficiency Single‐Junction Perovskite and 4T Perovskite/CIGS Tandem Solar Cells
Authors: Tang Liting , Wang Xiaomin , Liu Xinxing , Zhang Junjun , Wang Shaoying , Zhao Yuqi , Gong Junbo , Li Jianmin , Xiao Xudong 
Published: June 2022

AbstractThe interface between the perovskite layer and the hole transport layer (HTL) plays a vital role in hole extraction and electron blocking in perovskite solar cells (PSCs), and it is particularly susceptible to harmful defects. Surface passivation is an effective strategy for addressing the above concerns. However, because of its strong polarity, isopropyl alcohol (IPA) is used as a solvent in all of the surface treatment materials reported thus far, and it frequently damages the surface of perovskite. In this paper, a method is proposed for dissolving the passivation materials, for example, guanidine bromide (GABr), in mixed solvents (1:1) of IPA and toluene (TL), which can efficiently passivate interface and grain boundary defects by minimizing the IPA solubility of the perovskite surface. As a result, all the performance parameters Voc, Jsc, and FF are improved, and the power conversion efficiency (PCE) increased from 20.1 to 22.7%. Moreover, combining the PSCs with GABr post‐treatment in mixed solvents with copper indium gallium selenide (CIGS) solar cells, a 4‐terminal (4T) perovskite/CIGS tandem device is realized and a PCE of 25.5% is achieved. The mixed solvent passivation strategy demonstrated here, hopefully, will open new avenues for improving PSCs’ efficiency and stability.
The role of agricultural insurance in boosting agricultural output: An aggregate analysis from Chinese provinces
Authors: Zou Baoling , Ren Zanjie , Mishra Ashok K. , Hirsch Stefan 
Published: June 2022

AbstractAgricultural insurance is a significant driver of agricultural development worldwide. In this paper, a fixed‐effects panel approach and instrumental variable regressions are used to examine the impact of agricultural insurance on agricultural output in China. The study is based on panel data from 31 Chinese provinces over the period 2004 to 2018. Findings indicate that agricultural insurance led to a significant increase in aggregate agricultural output across provinces. The results remain robust when potential endogeneity in insurance uptake is considered. In addition, mechanism tests were performed to identify the channels through which insurance influences productivity. These show that agricultural insurance contributes to increasing labor productivity and the area of cultivated land per capita and encourages specialized planting, all of which promote growth in agricultural production. Finally, agricultural insurance plays a more important role in Eastern China and nonmajor crop‐producing areas [EconLit Citations: Q13, Q18].
The Microscopic Diamond Anvil Cell: Stabilization of Superhard, Superconducting Carbon Allotropes at Ambient Pressure
Authors: Wang Xiaoyu , Proserpio Davide M. , Oses Corey , Toher Cormac , Curtarolo Stefano , Zurek Eva 
Published: June 2022

AbstractA metallic, covalently bonded carbon allotrope is predicted via first principles calculations. It is composed of an sp3 carbon framework that acts as a diamond anvil cell by constraining the distance between parallel cis‐polyacetylene chains. The distance between these sp2 carbon atoms renders the phase metallic, and yields two well‐nested nearly parallel bands that cross the Fermi level. Calculations show this phase is a conventional superconductor, with the motions of the sp2 carbons being key contributors to the electron–phonon coupling. The sp3 carbon atoms impart superior mechanical properties, with a predicted Vickers hardness of 48 GPa. This phase, metastable at ambient conditions, could be made by on‐surface polymerization of graphene nanoribbons, followed by pressurization of the resulting 2D sheets. A family of multifunctional materials with tunable superconducting and mechanical properties could be derived from this phase by varying the sp2 versus sp3 carbon content, and by doping.
Pore‐Structure Control in Metal–Organic Frameworks (MOFs) for Capture of the Greenhouse Gas SF6with Record Separation
Authors: Wang Shao‐Min , Mu Xuan‐Tong , Liu Hao‐Ran , Zheng Su‐Tao , Yang Qing‐Yuan 
Published: June 2022

AbstractIn the electronics industry, the efficient recovery and capture of sulfur hexafluoride (SF6) from SF6/N2mixtures is of great importance. Herein, three metal–organic frameworks with fine‐tuning pore structures,Cu(peba)2,Ni(pba)2, andNi(ina)2, were designed for SF6capture. Among them,Ni(ina)2has perfect pore sizes (6 Å) that are comparable to the kinetic diameter of sulfur hexafluoride (5.2 Å), affording the benchmark binding affinity for SF6gas.Ni(ina)2exhibits the highest SF6/N2selectivity (375.1 at 298 K and 1 bar) and ultra‐high SF6uptake capacity (53.5 cm3 g−1at 298 K and 0.1 bar) at ambient conditions. The remarkable separation performance ofNi(ina)2was verified by dynamic breakthrough experiments. Theoretical calculations and the SF6‐loaded single‐crystal structure provided critical insight into the adsorption/separation mechanism. This porous coordination network has the potential to be used in industrial applications.
Mediating CO2 Electroreduction Activity and Selectivity over Atomically Precise Copper Clusters
Authors: Liu Li‐Juan , Wang Zhi‐Yuan , Wang Zhao‐Yang , Wang Rui , Zang Shuang‐Quan , Mak Thomas C. W. 
Published: June 2022

AbstractAtomically precise copper clusters are highly desirable catalysts for electrocatalytic CO2 reduction reaction (CO2RR) and provide an ideal platform for elaborating structure–activity relationships. However, systematic comparative studies of Cu cluster isomers for electrocatalytic CO2RR are lacking because they are challenging to synthesize. A group of structurally precise Cu8 cluster isomers with different core structures (cube‐ and ditetrahedron‐shaped) were developed and investigated for highly active and selective CO2 reduction. Electrocatalytic measurements showed that the ditetrahedron‐shaped Cu8 cluster exhibited a higher FEHCOOH (≈92 %) at −1.0 V and higher selectivity than the cube‐shaped cluster. Theoretical investigations revealed different levels of competitiveness with the hydrogen evolution reaction on the respective core‐shaped Cu8 clusters and decreased free energies for the adsorbed HCOO* intermediates on the ditetrahedron‐shaped Cu8 clusters.
Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals With Knee Osteoarthritis: Data From the Osteoarthritis Initiative Cohort
Authors: Lo Grace H. , Vinod Surabhi , Richard Michael J. , Harkey Matthew S. , McAlindon Timothy E. , Kriska Andrea M. , Rockette‐Wagner Bonny , Eaton Charles B. , Hochberg Marc C. , Jackson Rebecca D. , Kwoh C. Kent , Nevitt Michael C. , Driban Jeffrey B. 
Published: June 2022

ObjectiveTo assess the relationship between walking for exercise and symptomatic and structural disease progression in individuals with knee osteoarthritis (OA).MethodsWe assessed a nested cohort of participants age 50 years or older within the Osteoarthritis Initiative, a community‐based observational study in which subjects were enrolled between 2004 and 2006. We focused on 4 dichotomous outcomes from baseline to the 48‐month visit, involving determination of the frequency of knee pain and radiographic severity of knee OA on posteroanterior semiflexed knee radiographs. The outcomes assessed included 1) new frequent knee pain, 2) worsening of radiographic severity of knee OA based on the Kellgren/Lawrence grade, 3) progression of medial joint space narrowing, and 4) improved frequent knee pain. We used a modified version of the Historical Physical Activity Survey Instrument to ascertain those subjects who reported walking for exercise after age 50 years. The survey was administered at the 96‐month visit (2012–2014).ResultsOf 1,212 participants with knee OA, 45% were male and 73% reported walking for exercise. The mean ± SD age was 63.2 ± 7.9 years, and the mean ± SD body mass index was 29.4 ± 4.6 kg/m2. The likelihood of new frequent knee pain was reduced in participants with knee OA who walked for exercise as compared to those who were non‐walkers (odds ratio [OR] 0.6, 95% confidence interval [95% CI] 0.4–0.8), and progression of medial joint space narrowing was less common in walkers compared to non‐walkers (OR 0.8, 95% CI 0.6–1.0).ConclusionIn individuals with knee OA who were age 50 years or older, walking for exercise was associated with less frequent development of knee pain. These findings support the notion that walking for exercise should be encouraged for people with knee OA. Furthermore, we offer a proof of concept that walking for exercise could be disease modifying, which warrants further study.
Bifurcation anti‐control technique in a fractional‐order stable finance model
Authors: Xu Changjin , Mu Dan , Aouiti Chaouki , Liu Zixin , Qin Qiwen , Yao Lingyun , Hou Ming 
Published: June 2022

AbstractSetting up differential models to give a description of the object economical phenomenon in the world today is very essential in economics and mathematics. In this current study, we are committed to the study on the anti‐control of Hopf bifurcation for a fractional‐order stable finance model. By virtue of a suitable washout filter controller involving time delay, we obtain a fractional‐order controlled finance model. Selecting the time delay as bifurcation parameter, we derive a new delay‐independent stability and bifurcation condition to assure that the involved fractional‐order controlled finance model is locally asymptotically stable and generates Hopf bifurcation around the equilibrium point. The investigation clearly manifests that the designed washout filter controller is a very effective means of bifurcation anti‐control. Ultimately, the obtained simulation figures and bifurcation diagrams are sufficiently presented to verify effectiveness for the proposed control technique. The established theoretical fruits have great significance in maintaining financial balance. Up to the present, the report on anti‐control technique of Hopf bifurcation for fractional‐order dynamical systems is quite rare. The research idea can also be applied to probe into the control issue of bifurcation and chaos for numerous other fractional‐order dynamical models in many areas.
(Nano)platforms in bladder cancer therapy: Challenges and opportunities
Authors: Ashrafizadeh Milad , Zarrabi Ali , Karimi‐Maleh Hassan , Taheriazam Afshin , Mirzaei Sepideh , Hashemi Mehrdad , Hushmandi Kiavash , Makvandi Pooyan , Nazarzadeh Zare Ehsan , Sharifi Esmaeel , Goel Arul , Wang Lingzhi , Ren Jun , Nuri Ertas Yavuz , Kumar Alan Prem , Wang Yuzhuo , Rabiee Navid , Sethi Gautam , Ma Zhaowu 
Published: June 2022

AbstractUrological cancers are among the most common malignancies around the world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for the treatment of bladder cancer although its prognosis remains unfavorable. It is perceived that treatment of bladder cancer depends on an interdisciplinary approach combining biology and engineering. The nanotechnological approaches have been introduced in the treatment of various cancers, especially bladder cancer. The current review aims to emphasize and highlight possible applications of nanomedicine in eradication of bladder tumor. Nanoparticles can improve efficacy of drugs in bladder cancer therapy through elevating their bioavailability. The potential of genetic tools such as siRNA and miRNA in gene expression regulation can be boosted using nanostructures by facilitating their internalization and accumulation at tumor sites and cells. Nanoparticles can provide photodynamic and photothermal therapy for ROS overgeneration and hyperthermia, respectively, in the suppression of bladder cancer. Furthermore, remodeling of tumor microenvironment and infiltration of immune cells for the purpose of immunotherapy are achieved through cargo‐loaded nanocarriers. Nanocarriers are mainly internalized in bladder tumor cells by endocytosis, and proper design of smart nanoparticles such as pH‐, redox‐, and light‐responsive nanocarriers is of importance for targeted tumor therapy. Bladder cancer biomarkers can be detected using nanoparticles for timely diagnosis of patients. Based on their accumulation at the tumor site, they can be employed for tumor imaging. The clinical translation and challenges are also covered in current review.