bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of Illness-related Uncertainty With Mental Health in Systemic Autoimmune Rheumatic Diseases
Authors: Wallace Zachary S. , Cook Claire , Finkelstein-Fox Lucy , Fu Xiaoqing , Castelino Flavia V. , Choi Hyon K. , Perugino Cory , Stone John H. , Park Elyse R. , Hall Daniel L. 
Published: April 2022

ObjectivePatients with systemic autoimmune rheumatic diseases (SARDs) face illness-related uncertainty, but little is known about the psychological profiles and psychosocial and health needs associated with uncertainty among adults with SARDs.MethodsPatients from the Massachusetts General Hospital with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), IgG4-related disease (IgG4-RD), and systemic sclerosis (SSc) completed the Mishel Uncertainty in Illness Scale, 8-item Patient Health Questionnaire depression scale, 7-item General Anxiety Disorder scale, Sickness Impact Profile, and a survey of psychosocial needs. The associations of uncertainty and self-reported needs with depression, anxiety, and sickness impact were assessed.ResultsOne hundred thirty-two patients with AAV (n = 41, 31%), IgG4-RD (n = 61, 46%), or SSc (n = 30, 23%) participated. The mean age was 64 years, 52% were female, and 83% were White. Greater illness-related uncertainty was positively correlated with higher levels of depression (r= 0.43,P< 0.001), anxiety (r= 0.33,P< 0.001), and sickness impact (r= 0.28,P= 0.001). We observed variations in these measures across SARDs, such that uncertainty was more strongly associated with depression and sickness impact in AAV or SSc compared to IgG4-RD. The primary needs that patients endorsed were services for managing physical symptoms (53%), self-care (37%), and emotional concerns (24%), with greater needs strongly associated with greater illness-related uncertainty.ConclusionAmong patients with SARDs, illness-related uncertainty is correlated with levels of depression, anxiety, and sickness impact, as well as psychosocial needs. Findings also implicate the need for targeted interventions to address uncertainty and needs among subgroups of patients with different illness profiles.
LECT2 Is a Novel Antibacterial Protein in Vertebrates
Authors: Hu Ya-Zhen , Ma Zi-You , Wu Chang-Song , Wang Jie , Zhang Yong-An , Zhang Xu-Jie 
Published: April 2022

Abstract
In vertebrates, leukocyte-derived chemotaxin-2 (LECT2) is an important immunoregulator with conserved chemotactic and phagocytosis-stimulating activities to leukocytes during bacterial infection. However, whether LECT2 possesses direct antibacterial activity remains unknown. In this article, we show that, unlike tetrapods with a single LECT2 gene, two LECT2 genes exist in teleost fish, named LECT2-a and LECT2-b. Using grass carp as a research model, we found that the expression pattern of grass carp LECT2-a (gcLECT2-a) is more similar to that of LECT2 in tetrapods, while gcLECT2-b has evolved to be highly expressed in mucosal immune organs, including the intestine and skin. Interestingly, we found that gcLECT2-b, with conserved chemotactic and phagocytosis-stimulating activities, can also kill Gram-negative and Gram-positive bacteria directly in a membrane-dependent and a non–membrane-dependent manner, respectively. Moreover, gcLECT2-b could prevent the adherence of bacteria to epithelial cells through agglutination by targeting peptidoglycan and lipoteichoic acid. Further study revealed that gcLECT2-b can protect grass carp from Aeromonas hydrophila infection in vivo, because it significantly reduces intestinal necrosis and tissue bacterial load. More importantly, we found that LECT2 from representative tetrapods, except human, also possesses direct antibacterial activities, indicating that the direct antibacterial property of LECT2 is generally conserved in vertebrates. Taken together, to our knowledge, our study discovered a novel function of LECT2 in the antibacterial immunity of vertebrates, especially teleost fish, greatly enhancing our knowledge of this important molecule.
Mind Covid, Remember Mask" To Reduce Corona Spreading (A Case Study In The Johan Pahlawan Sub-District, Meulaboh City, West Aceh)
Authors: Musliyadi  , Irmayanti  
Published: March 2022

The coronavirus spread has been the main issue among Acehnese people since it occurred. Every day, people get infected; some people also are starting to recover from the coronavirus. The governments have been working to reduce the risked people and infected victims by providing various personal protective equipment and educating the public about the virus and its threats. Those all require society to obey them, such as wearing masks to avoid being infected or transmit to other people. Until now, the spread of the coronavirus is also very high trending. The Covid-19 task force in Jakarta on February 16th, 2021 recorded that the ratio of coronavirus cases has reached 38.34 percent. This figure shows the highest daily record since the pandemic took place. This study used a descriptive method with a qualitative approach. Data collection was performed by interviewing several communities in the Johan Pahlawan sub-district, monitoring and observing in the field, and reading relevant sources. The study found a low level of community compliance with health protocols. The use of masks is still very lacking; people only wear masks when raids are carried out on the streets by joint government officials.
Comparison of mean pain score of oral non-steroidal antiinflammatory agents and locally injectable steroid for the treatment of plantar fasciitis
Authors: Muhammad Rizwan Akram  , Muhammad Nadeem Yousaf  , Muhammad Waseem  , Fizah Sajjad Chaudhary  
Published: April 2022

Objective: To compare the efficacy of oral non-steroidal anti-inflammatory drugs with locally injectable steroids in the treatment of plantar fasciitis.
Method: The randomised controlled trial was conducted from 10 May 2013 to 10 December 2013 at the Department of Orthopaedic Surgery, Punjab Medical College/Allied Hospital, Faisalabad, Pakistan, and comprised patients of either gender aged 26-60 years having unilateral plantar fasciitis who were not on any prior treatment and had moderate to severe pain intensity. The patients were randomised into group A, which received diclofenac sodium 50mg and acetaminophen 500mg twice a day for 4 weeks, and group B, which received a single injection of 40mg (1ml) of methylprednisolone combined with 2ml of 0.5% bupivacaine into the tender most point of the inflamed plantar fascia. Pain was assessed using visual analogue scale at baseline and after 2 months of regular follow-up. Data was analysed using SPSS 10.
Results: Of the 140 patients, there were 70(50%) in each of the two groups. There were 102(72.9%) males and 38(27.1%) females, with an overall mean age of 42.24±9.30 years. While pain intensity decreased in both the groups, it was significant in group B (p=0.0001), but non-significant in group A (p=0.723).
Conclusion: Locally injectable steroid was found to be a better modality for the management of plantar fasciitis in reducing mean pain score and sustained pain relief compared to non-steroidal anti-inflammatory drugs.
Key Words: Mean pain score, VAS, NSAIDs, Planter fasciitis.
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Epidemiological, Clinical, and Radiological comparison of adult and Pediatric features in COVID-19: A Scoping Review
Authors: Parkar Sadia , Pethani Asma , Syeda Mah-e-Jabeen Zehra  , Khan Faheem Ullah , Kazi Zaubina , Hilal Kiran , Saleem Ali Faisal 
Published: April 2022

Objective: To assess epidemiological, clinical, and radiological characteristics of the coronavirus disease in children and adults.
Method: The scoping review comprised search on PubMed, Scopus Cochrane, and Google Scholar databases from January 2020 to April 2021 for English-language articles dealing with clinical and radiological manifestations amongst children and adults affected by coronavirus disease. Two reviewers independently screened the titles and abstracts.
Results: Of the 389 studies initially identified, 39(10%) were reviewed in detail. Data suggested that children were less frequently affected by the coronavirus disease. The affected children showed milder disease with low case fatalities compared to the adults.
Conclusions: There exists significant gaps in knowledge of clinical and radiological aspects of coronavirus disease, but the available scientific data showed that the disease seems to be unusual in children.
Key Words: Children, COVID-19, SARS-CoV2, Epidemiology, Clinical, Radiological.
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Surgical fixation of metastatic spine fractures: 6-months experience at a cancer hospital from a developing country- an audit
Authors: Arshad Ayesha , Irfan Yousaf  
Published: April 2022

Objective: To audit the outcomes in cases of surgical fixation for metastatic spine fractures at a single centre.
Method: The retrospective audit was conducted at the Surgical Oncology Department of the Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised data of all patients who underwent surgery for metastatic spine fractures from December 1, 2019, to May 31, 2020. The patients were followed up for three months after the surgery. Pre-surgery American Spinal Injury Association Impairment Scale grades were compared with post-operative grades for all the patients. Data was analysed using SPSS 20.
Results: Of the 16 patients, 12(75%) were females and 4(25%) were males, with an overall mean age of 44.0+/-11.9 years (range: 24-64 years). The only co-morbid was hypertension, which was present in 6(37.5%) patients. The most common primary site was breast 10(62.5%), and 12(75%) patients presented more than 12 months after the initial diagnosis. Lumbar spine was involved in 10(62.5%) cases. Pre-operative American Spinal Injury Association Impairment Scale grade was E in 8(50%) patients. Post-operatively, 14(87.5%) patients had the E grade. There was complication in 1(6.25%) case that had a post-operative wound infection.
Conclusion: Surgery for spinal metastases was found to be a safe and viable option for patients with metastatic spine fractures in resource-limited countries like Pakistan.
Key Words: Metastasis, Spine, Fractures, Surgical fixation.
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DEPENDENCIA EMOCIONAL COMO RASGO PREDISPONENTE EN LA VIOLENCIA PSICOLÓGICA
Authors: Tutiven Abad Tanya , Larrea Simball Leopoldo Javier , Peñafiel Ana , Velez Hidalgo Judith 
Published: March 2022

La salud mental de los seres humanos es tan importante, como la salud física, por lo que requiere de cuidados y atención desde las primeras etapas de vida. Por otro lado, la violencia afecta la integridad de las personas desde todos los aspectos. En el caso de la violencia psicológica, afecta directamente la psiquis, ocasionando baja autoestima, miedos, inseguridades y dependencia emocional. Es por ello que el objetivo de esta investigación es, describir la dependencia emocional como rasgo predisponente en la violencia psicológica concebida en las leyes ecuatorianas. Para cumplir con este propósito, se empleó la metodología de un estudio de revisión, de tipo monográfico, para la búsqueda de la información, se realizó un arqueo bibliográfico de más 50 artículos científicos relacionados con la temática, el análisis de la información se llevó a cabo bajo la técnica del fichaje, subrayado y de la lectura analítica. En el Ecuador, es vista las tasas altas de las denuncias sobre la violencia contra la mujer, se ha creado todo un marco legal para velar por la protección de las víctimas y para que el victimario responda ante la ley por el delito cometido.

ABSTRACT
The mental health of humans is as important as physical health, so it requires care and attention from the early stages of life. On the other hand, violence affects the integrity of people from all aspects. In the case of psychological violence, it directly affects the psyche, causing low self-esteem, fears, insecurities and emotional dependence. That is why the objective of this research is to describe emotional dependence as a predisposing trait in psychological violence conceived in Ecuadorian laws. To fulfill this purpose, the methodology of a review study, of monographic type, was used for the search of information, a bibliographic archaeum was made of more than 50 scientific articles related to the subject, and the analysis of the information was carried out under the technique of signing, underlining and analytical reading. In Ecuador, in view of the high rates of complaints about violence against women, a legal framework has been created to ensure the protection of victims and to hold the perpetrator accountable for the crime committed
Encephalitis associated with Covid-19 and thunderclap headache: an unusual relationship
Authors: Rocha Emanuelle Bianchi da Silva , Eberhardt Camila Moraes , Tubero Luciana de Azevedo , Penatti Letícia Araújo Tassini , Galego Andressa Regina de Mello 
Published: April 2022

The Covid-19 is characterized by respiratory symptoms, however this virus frequently damages the nervous system, although the exact mechanism involved is still unclear. Headache is the most common neurological symptom and has a great heterogeneity, including thunderclap headache which should be considered a red flag on emergency departments. Case report: female, 51 years-old, with thunderclap headache started seven days ago that evolved to mental confusion, inattention and language plus memory disturbance at the day of admission. General physical examination was normal except by the presence of borderline pyrexia (37.7°C). Neurological examination showed no particularities, except for mental and cognitive alterations. Computed angiotomography of the brain excluded bleeding but showed one aneurysm. Cerebrospinal fluid (CSF) had no xanthochromia, but evidenced a lymphomonocytic pleocytosis with discrete hyperproteinorraquia. Due to hospital protocol the patient underwent computed tomography of thorax and we found ground-glass opacities suggesting viral infection. Then, RT-PCR for SARS-CoV-2 with nasopharyngeal swab and in CSF was performed with both positives. Therefore the diagnosis was encephalitis associated with COVID-19. We opted for supportive care only. Patient evolved with many complications, need of ventilatory support and renal replacement therapy, but she was discharged after 35 days with no symptoms and at follow-up, two months later, the only finding was mild inattention. Discussion: when faced with a case with thunderclap headache, especially with other neurological findings, the first step is excluded subarachnoid hemorrhage, but health professionals should keep in mind the differential diagnoses, mainly infectious and highly contagious diseases such as COVID-19.
Technology Role in Maternal and Infant Mortality Ratios in Cameroon-West Africa. Midwives and Nurses Perception. A Cross-sectional Quantitative Survey.
Authors:   , Pivadga Collins , Ekpah Daniel 
Published: March 2022

Background: Glocal efforts to curb the maternal/infant mortality ratio have not reached a satisfactory level with Sub-Saharan countries accounting for 86% (25400) of the global maternal death in 2017. However, technology has enhanced prompt management of preventable maternal/infant deaths via remote obstetric consultations/care along the whole continuum of pregnancy, childbirth, and postnatal care. Aim: The survey aimed at assessing midwives' and nurses' perceptions on the role of tele-obstetrics in improving maternal/infant mortality in Africa and the significance of educational qualification and years of work experience on perception. Methodology; The survey employed quantitative and non-probability convenient sampling techniques to select 138 midwives and nurses. Data collection tool was used to collect data in two phases; phase-I as web-base (22nd-28th February 2021) and phase II, self-administered (1st-5th March 2021) using questionnaire then descriptive and inferential statistics were computed at 95% Confidence Interval on Statistical Package for Social Sciences version 20 and presented in the form of tables, pie charts, and bar charts. Results: The respondent rate was 86% (118/138), and at a mean score of 1.31(0.043)±0.466, 68.6% (81/118) of participants perceived tele-obstetrics vital to curb maternal/infant mortality. Among those with positive perception, 43.2%(35/81) [chi-2=6.3(33.3%)0.27] had a bachelor of science in midwifery/nursing. Within those with ≤5years experience, 74.6%(47/63) [chi2=4.9(37.5%)0.17] supported technological application in midwifery care. Conclusion: Midwives and nurses recognize tele-obstetrics capable of improving maternal/infant health, and this recognition is not so different amongst the different cadre of Midwives/Nurses although those with few years of work experience support tele-obstetrics than those with many years of work experience. Recommendation: It is recommended for all United Nations member states to create a platform that encourages the implementation of tele-obstetric systems in all healthcare settings and midwifery curriculum as midwives and nurses will be willing to improve care via the use of technology.
Taustamusiikkipalvelut ja toimijuus
Authors: Uimonen Heikki 
Published: April 2022

Embedded in the study of ‘music in culture’, agency can be perceived in ways in which a society musically defines itself, its taxonomy of music, and its ideas of what music can do. The article discusses that although music is a ‘resource for modulating and structuring the parameters of aesthetic agency’ such as feeling, motivation and desire (de Nora 2000), its public use is enabled, restricted and shaped by social and cultural contexts and agencies. By analysing interviews with the personnel of diverse background music companies, the article will concentrate on how agency is manifest in designing sonic environments of commercial premises and how companies can be approached as music cultures. Methodologically, this demands culture-specific understanding of background music history, skills and professional networks of the participants. Despite being part of the international music industry, background music is not to be detached from its culture, time and space where it is being heard, listened to and consumed.
Peurankaataja Pedri ja oman mahdin soitto
Authors: Kastinen Arja 
Published: April 2022

Pedri Shemeikka’s heritage for musical culture from the perspective of a researcher-musician
This article examines the cultural-historical background and aesthetic-philosophical essence of Karelian 19th-century kantele improvisation through one historical figure, Pedri Shemeikka. I approach the subject from the perspective of a musician-researcher and my main research questions focus on whether and how it is possible to reconstruct and revive a music tradition of which we have only some written documents. This particular tradition was an inseparable part of the ancient runosong culture and was collected among the illiterate Ladoga and Aunus Karelian people who still lived in the slash-and-burn culture that included hunting and fishing as an important part of one’s livelihood. Pedri Shemeikka was a considerable person inside this tradition and at the turn of the 19th and 20th centuries, he became a symbol of the heroic Väinämöinen for the Finnish intelligentsia.
When explaining their improvised music, the kantele players themselves were talking about ”soittaa omaa mahtia” – playing their own power (with their inner strength and knowledge). The article examines the centuries-old connections between Karelians and the Sámi and the possible connection between kantele players ”own power” and prehistoric shamanism. The end of the article focuses on how the information we have of the instruments, the detailed descriptions of the special plucking technique, the scales, the tuning system, and the aesthetics of the music inside the runosong culture, give us tools to learn and understand the deeper essence of this music and make it available and alive for the people of the twenty-first century.
MANEJO COMUNITÁRIO DE RECURSOS NATURAIS: UMA REVISÃO DE LITERATURA
Authors: Soares Francisco Igo Leite , Santos Ernélison Angly da Silva , Lameira Helton Luis Nina 
Published: April 2022

A ascensão do modelo mercadológico baseado no acúmulo de capital, e na exploração dos recursos naturais de forma não sustentável, tem provocado mudanças significativas na vida dos povos tradicionais, indígenas, quilombolas e pequenos agricultores familiares no Brasil, e, sobretudo, na região Amazônica. Assim, este trabalho tem por objetivo evidenciar o contexto do manejo florestal comunitário – MFC, a partir de diretrizes legais e das políticas públicas de fortalecimento as cadeias produtivas deste setor. Para tanto, metodologicamente, trata-se de uma revisão de literatura baseada em artigos de periódicos que abordam a temática. Desse modo, verifica-se que um esforço conjunto entre os entes federados e a sociedade civil organizada, resultou na criação de Unidades de Conservação (UC), e na implementação de Planos de Manejo Comunitário Familiar - PMCF, com vistas a conservar os recursos florestais (madeireiros e não-madeireiros), desenvolver alternativas econômicas viáveis para as populações tradicionais, bem como, promover o desenvolvimento sustentável a partir do manejo comunitário de recursos naturais. Apesar disso, o MFC ainda enfrenta grandes desafios que vão desde a falta de regularização fundiária e linhas de créditos específicas até a vulnerabilidade na assistência técnica florestal e escala de produção. Portanto, o MFC tem perspectivas favoráveis para continuar a se desenvolver e tornar-se uma legítima fonte de produtos florestais.
USO DO METILFENIDATO PARA O MELHORAMENTO ACADÊMICO
Authors: Alves Francisco Wamilson Lima , Andrade Leonardo Guimarães de 
Published: April 2022

O metilfenidato é aprovado para uso no tratamento do Transtorno de Déficit de Atenção e Hiperatividade e Narcolepsia, no entanto, tem-se muito utilizado com fins não terapêuticos. Nesse contexto, o objetivo do artigo é apresentar a investigação sobre o uso de Ritalina (metilfenidato) por estudantes universitários para aprimoração do desempenho cognitivo no ambiente acadêmico e também reunir dados sobre as motivações, expectativas, efeitos e prejuízos do uso não prescrito de metilfenidato por universitários, por meio de uma revisão de literatura com abordagem exploratória e descritiva, na qual foram realizadas pesquisas em bancos de dados digitais como: SCieLo Pubmed, LIlacs e Google acadêmico. Os resultados demonstram que metilfenidato é o psicoestimulantes mais consumido no mundo, com características farmacológicas semelhantes às anfetaminas, portanto com potencial de abuso. Seus usos off-label incluem como tratamento para fadiga em pacientes com câncer, depressão refratária na população geriátrica, apatia na doença de alzheimer e para melhorar o desempenho cognitivo. Diante disso, os estudantes têm utilizado por automedicação, através de indicação de amigos para melhorar a concentração, o estado de alerta e o desempenho acadêmico, ou para fins recreativos, o qual maior percentual de consumo é notado nos alunos de medicina, além disso, padrão de consumo varia conforme a prevalência de consumo o período do curso. Portanto, é essencial estratégias de promoção de educação em saúde para o uso racional do medicamento.