bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan teknologi sudah dilakukan di banyak bidang kehidupan seperti sudah banyaknya aplikasi baik berbasis website ataupun android yang menjadi sahabat bagi semua lapisan masyarakat. Sebagian besar masyarakat hanya dapat menggunakan teknologi tersebu
Authors: Widayani Hapsari , Burhanudin Burhanudin 
Published: February 2022

Pemanfaatan teknologi sudah dilakukan di banyak bidang kehidupan seperti sudah banyaknya aplikasi baik berbasis website ataupun android yang menjadi sahabat bagi semua lapisan masyarakat. Sebagian besar masyarakat hanya dapat menggunakan teknologi tersebut dan Sebagian kecil lainnya bukan hanya dapat menggunakan tetapi juga dapat membuat teknologi tersebut dengan bantuan suatu tools pemrograman. Pemrograman sendiri dapat dibuat dengan konsep native ataupun konsep OOP (Object Oriented Programming). Banyak programmer dapat membuat program dengan konsep native tetapi tidak banyak programmer yang dapat membuat program dengan konsep OOP. Selain programmer, banyak pula mahasiswa yang belum memahami konsep OOP apalagi untuk membuatnya dalam bentuk sebuah website. Mahasiswa-mahasiswa tersebut mau tidak mau harus mengikuti workshop pelatihan mengenai OOP agar ilmu di bidang IT dapat meningkat. Berdasarkan permasalahan tersebutlah, tim pengabdian dosen mengadakan pengabdian tentang Pelatihan Object Oriented Programming dalam Pembuatan Website Masa Kini. OOP merupakan pemrograman berbasis objek yang menerapkan metode class dan object sebagai pendukungnya. Pengabdian yang dilakukan tidak hanya penjelasan secara teori tetapi juga secara praktik agar para mahasiswa dapat langsung mempraktikkan apa yang sudah dijelaskan oleh tutor. Hasil dari kegiatan ini adalah para mahasiswa dapat membuat suatu website yang dibuat dengan menggunakan OOP dan ilmu serta wawasan mereka mengenai pemrograman dapat meningkat.
Kata Kunci: OOP, website, pemrograman
Spatial analysis of soybean yield in the western mesoregion of Paraná using agrometeorological variables
Authors: Gabriel Caroline Cristina Engel , Uribe Opazo Miguel Angel , Dalposso Gustavo Henrique , Cima Elizabeth Giron 
Published: February 2022

This paper aimed to analyze the spatial autocorrelation of soybean yield and its bivariate spatial correlation with theagrometeorological variables rainfall, mean temperature, and mean global solar radiation in 2014/2015, 2015/2016, and 2016/2017 crop years in the West of the State of Paraná – Brazil. To achieve this objective, techniques of spatial statistics of areas were used, which, through autocorrelation and spatial correlation indices, sought to identify patterns of association between soybean yield and agrometeorological variables. This research is justified because in addition to the soybean crop being the main source of food protein and vegetable oil in the world and the agrometeorological variables being the factors that most influence it, the western mesoregion of Paraná stands out with the highest production values in the state. Thus, it is important to monitor its development through spatial analysis to obtain information that will support decision making. The global and local Moran’s indices showed that soybean yield is self-correlated in the municipalities of Western Paraná, identifying clusters to the west and east of the mesoregion. The significance of the bivariate spatial correlation indices confirmed the influence of the variables rainfall, mean temperature, and average global solar radiation on soybean yield.
O impacto da pandemia SARS-CoV-2 no marketing da enfermagem: uma revisão integrativa
Authors: David Marcos José Vilchez , Oliveira Juliana Lana Querino de , Silva Maria Virginia Godoy da , Silva Leandro Andrade da , Silva Roni Robson da , Neves Milena Preissler das 
Published: February 2022

A pandemia pelo SARS-Cov-2 assombra o planeta desde o ano de 2020, dizimando milhares de pessoas em todo o mundo. Esse momento poderia ser propício para que o mundo reconhecesse o valor dos profissionais de saúde, do enfermeiro e da Enfermagem. Objetivo: Analisar as produções científicas sobre o impacto da pandemia pela SARS-Cov-2 no marketing da Enfermagem. Metodologia: Revisão integrativa da literatura, de acordo com a estratégia PICo e procedimentos definidos pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Bases de dados consultadas: Assia_Coronavírus; BVS; CINAHIL; Embase; PubMed; SciELO; Scopus e WOS. Resultados: Onze estudos foram selecionados para análise. A Enfermagem ganhou holofotes pela atuação. Os profissionais de enfermagem tiveram pouco acesso a Equipamentos de Proteção Individual (EPIs) adequados; faltaram espaços e recursos apropriados para a assistência e um subdimensionamento das equipes. O Brasil liderou o ranking mundial de óbitos de profissionais de enfermagem. O não reconhecimento do poder da profissão; altas jornadas de trabalho, salários baixos, resultam na desvalorização do trabalho do próprio enfermeiro Conclusão: Durante a pandemia pela SARS-CoV-2, a Enfermagem esteve na linha de frente, o que possibilitou de certa forma maior visibilidade profissional. As condições de trabalho desfavoráveis, baixos salários e outros desafios enfrentados pelos profissionais de enfermagem sinalizam que a profissão ainda carece de reconhecimento e que esforços para o marketing favorável precisam ser empenhados.
Pertumbuhan Eucheuma denticulatum Berdasarkan Kedalaman Yang Dipelihara Dengan Metode Vertinet
Authors: Mursalim Ode , Ruslaini Ruslaini , Kasim Ma’ruf 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui laju pertumbuhan E. denticulatum terhadap kedalaman berbeda yang dibudidayakan dengan metode vertinet dan pengaruh parameter kualitas air terhadap pertumbuhan E. denticulatum yang dipelihara dengan kedalaman yang berbeda. Penelitin ini dilaksanakan pada bulan November-Desember 2019 yang bertempat di perairan Pantai Lakeba Kota Bau-Bau, Sulawesi Tenggara. Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) di mana terdiri dari 3 perlakuan dan 27 ulangan individu yakni perlakuan A (kedalaman 30 cm), perlakuan B (kedalaman 40 cm) dan perlakuan C (kedalaman 50 cm) dengan berat awal rumput laut 20 gram. Hasil penelitian menunjukkan bahwa laju pertumbuhan spesifik perlakuan A 3,74% perhari, perlakuan B 3,71% perhari dan perlakuan C 3,94% perhari. Hasil pengukuran parameter kualitas air menunjukkan bahwa kualitas air di lokasi penelitian masih dalam kisaran toleransi untuk pertumbuhan rumput laut E. denticulatum. Penelitian ini menyimpulkan bahwa E. denticulatum yang dipelihara dengan metode vertinet memiliki laju pertumbuhan spesifik yang baik yaitu lebih dari 3% perhari. Semakin dalam bibit E. denticulatum diletakkan dalam perairan maka pertumbuhan E. denticulatum semakin rendah. Kualitas air dapat mempengaruhi pertumbuhan E. denticulatum terutama pada parameter fosfat, nitrat dan salinitas. Kata Kunci : Kedalaman air laut, Vertinet, pertumbuhan rumput laut Eucheuma denticulatum
PENGARUH KOMPETENSI DAN INTEGRITAS TERHADAP KINERJA PENYULUH PERTANIAN YANG DIMEDIASI OLEH KEPUASAN KERJA PADA DINAS TANAMAN PANGAN, HOLTIKULTURA DAN PERKEBUNAN (TPHP) KAB. KONAWE
Authors: Syahruni Siti , Syaifuddin Dedy Takdir , Adam La Ode Bahana , Nur Nofal , Kohawan Muh. Rivan , Hasan Rachmat Riyaldi 
Published: February 2022

Penelitian ini untuk menguji dan membuktikan secara empiris pengaruh kompetensi,integritas dan kepuasan kerja sebagai variabel mediasi terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe.Penelitian ini merupakan Penelitian explanatory yang bertujuan menjelaskan Hubungan kausal antar variabel dengan menggunakan pendekatan kuantitatif. Populasi dan sampel dalam Penelitian ini adalah seluruh penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe 130 orang responden. Metode analisis untuk menjawab hipotesis dalam penelitian ini adalah Metode PLS (Partial Least Square)yang mengukur intensitas 3 variabel, yaitu variabel independen, variabel mediasi dan variabel dependen.Hasil Penelitian menunjukkan bahwa kompetensi, integritas secara parsial berpengaruh positif dan signifikan terhadap kepuasan kerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe. Kepuasan kerja berpengaruh positif dan signifikan terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe. Kompetensi secara parsial berpengaruh negatif dan tidak signifikan terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe sedangkan integritas secara parsial berpengaruh positif dan signifikan terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe. Untuk Variabel kepuasan kerja memediasi full antara kompetensi dan integritas terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten KonaweKata Kunci: Kompetensi, integritas, kepuasan kerja Dan Kinerja Penyuluh
PENGARUH LINGKUNGAN KERJA, KOMITMEN ORGANISASI DAN MOTIVASI KERJA TERHADAP KINERJA GURU DI SMA NEGERI 1 GU KABUPATEN BUTON TENGAH
Authors: Alimin Alimin , Hakim Adnan , Nasrul Nasrul , Mokodompit Eliyanti Agus , Sabri Sabri 
Published: February 2022

This study aims to explain and examine: (1) the effect of the work environment, organizational commitment, and work motivation on teacher performance, (2) the effect of the work environment on teacher performance, (3) the effect of organizational commitment on teacher performance, and (4) the effect of work motivation on teacher performance. This research approach is survey with explanatory research design. Data collection was carried out in a cross-sectional manner using an instrument in the form of a questionnaire. The population in this study were all 53 teachers of SMA Negeri 1 Gu. The sampling technique is a saturated sample (census) where the entire population is used as the research sample. Data analysis techniques to answer the research hypothesis are descriptive and multiple linear regression. The results showed that: (1) work environment, organizational commitment, and work motivation simultaneously had a significant effect on teacher performance, (2) work environment had a significant effect on teacher performance, (3) organizational commitment had a significant effect on teacher performance, (4) work motivation has a significant effect on teacher performance. Keywords: Work Environment, Organizational Commitment, Work Motivation Teacher Performance.
Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma
Authors: Liu Yong , Zheng Shunzhen , Wang Tao , Fang Ziqi , Kong Junjie , Liu Jun 
Published: February 2022

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C regulators in HCC.Methods: Based on 9 m5C regulators, the m5C modification patterns of HCC samples extracted from public databases were systematically evaluated and correlated with tumor immune and prognosis characteristics. An integrated model called the “m5Cscore” was constructed using principal component analysis, and its prognostic value was evaluated.Results: Almost all m5C regulators were differentially expressed between HCC and normal tissues. Through unsupervised clustering, three different m5Cclusters were ultimately uncovered; these clusters were characterized by differences in prognosis, immune cell infiltration, and pathway signatures. The m5Cscore was constructed to quantify the m5C modifications of individual patients. Subsequent analysis revealed that the m5Cscore was an independent prognostic factor of HCC and could be a novel indicator to predict the prognosis of HCC.Conclusion: This study comprehensively explored and systematically profiled the features of m5C modification in HCC. m5C modification patterns play a crucial role in the tumor immune microenvironment (TIME) and prognosis of HCC. The m5Cscore provides a more holistic understanding of m5C modification in HCC and provides a practical tool for predicting the prognosis of HCC. This study will help clinicians identify effective indicators of HCC to improve the poor prognosis of this disease.
Relevance of Cor Pulmonale in COPD With and Without Pulmonary Hypertension: A Retrospective Cohort Study
Authors: Yogeswaran Athiththan , Kuhnert Stefan , Gall Henning , Faber Marlene , Krauss Ekaterina , Rako Zvonimir A. , Keranov Stanislav , Grimminger Friedrich , Ghofrani Hossein Ardeschir , Naeije Robert , Seeger Werner , Richter Manuel J. , Tello Khodr 
Published: February 2022

BackgroundThe relevance of cor pulmonale in COPD and pulmonary hypertension due to COPD (PH-COPD) is incompletely understood. We aimed to investigate the relationship of right ventricular-pulmonary arterial (RV-PA) uncoupling with disease severity in COPD, and the relationship of RV-PA uncoupling and use of targeted PH therapies with mortality in PH-COPD.MethodsWe retrospectively analyzed 231 patients with COPD without PH and 274 patients with PH-COPD. COPD was classified according to GOLD stages and the modified Medical Research Council dyspnoea scale. PH was categorized as mild-to-moderate or severe. RV-PA uncoupling was assessed as the echocardiographic tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio.ResultsOf the cohort with COPD without PH, 21, 58, 54 and 92 were classified as GOLD I, II, III and IV, respectively. Patients in advanced GOLD stages and those with severe dyspnoea showed significantly decreased TAPSE/PASP.Of the PH-COPD cohort, 144 had mild-to-moderate PH and 130 had severe PH. During follow-up, 126 patients died. In univariate Cox regression, TAPSE/PASP and 6-min walk distance (6MWD; 10 m increments) predicted survival [hazard ratios (95% CI): 0.12 (0.03–0.57) and 0.95 (0.93–0.97), respectively]; notably, PH severity and simplified European Society of Cardiology/European Respiratory Society risk stratification did not. Among patients in the lowest or intermediate tertiles of TAPSE/PASP and 6MWD, those with targeted PH therapy had higher survival than those without (53 vs. 17% at 3 years).ConclusionCor pulmonale (decreased TAPSE/PASP and 6MWD) is associated with disease severity in COPD and predicts outcome in PH-COPD.
Improving Left Atrial Appendage Occlusion Device Size Determination by Three-Dimensional Printing-Based Preprocedural Simulation
Authors: Kim William D. , Cho Iksung , Kim Young Doo , Cha Min Jae , Kim Sang-Wook , Choi Young , Shin Seung Yong 
Published: February 2022

BackgroundThe two-dimensional (2D)-based left atrial appendage (LAA) occluder (LAAO) size determination by using transesophageal echocardiography (TEE) is limited by the structural complexity and wide anatomical variation of the LAA.ObjectiveThis study aimed to assess the accuracy of the LAAO size determination by implantation simulation by using a three-dimensional (3D)-printed model compared with the conventional method based on TEE.MethodsWe retrospectively reviewed patients with anatomically and physiologically properly implanted the Amplatzer Cardiac Plug and Amulet LAAO devices between January 2014 and December 2018 by using the final size of the implanted devices as a standard for size prediction accuracy. The use of 3D-printed model simulations in device sizing was compared with the conventional TEE-based method.ResultsA total of 28 cases with the percutaneous LAA occlusion were reviewed. There was a minimal difference [−0.11 mm; 95% CI (−0.93, 0.72 mm); P = 0.359] between CT-based reconstructed 3D images and 3D-printed left atrium (LA) models. Device size prediction based on TEE measurements showed poor agreement (32.1%), with a mean difference of 2.3 ± 3.2 mm [95% CI (−4.4, 9.0)]. The LAAO sizing by implantation simulation with 3D-printed models showed excellent correlation with the actually implanted LAAO size (r = 0.927; bias = 0.7 ± 2.5). The agreement between the 3D-printed and the implanted size was 67.9%, with a mean difference of 0.6 mm [95% CI (−1.9, 3.2)].ConclusionThe use of 3D-printed LA models in the LAAO size determination showed improvement in comparison with conventional 2D TEE method.
The Russian Registry of Chronic Hypoparathyroidism
Authors: Kovaleva Elena V. , Eremkina Anna K. , Elfimova Alina R. , Krupinova Julia A. , Bibik Ekaterina E. , Maganeva Irina S. , Gorbacheva Anna M. , Dobreva Ekaterina A. , Melnichenko Galina A. , Mokrysheva Natalia G. 
Published: February 2022

IntroductionChronic hypoparathyroidism is a relatively rare disease associated with multicomponent medical therapy and various complications. The analysis of large databases of patients with chronic hypoparathyroidism is a necessary tool to enhance quality of medical care, as well as to determine the optimal clinical and therapeutic approaches, and prognostic markers of the disease.The Aimof this study is to estimate the clinical and biochemical profile, long-term complications, medical therapy and disease control of the patients with chronic postsurgical and non-surgical hypoparathyroidism.Materials and Methodsthe cross-sectional, observational, continuous study was based on the Russian Registry of patients with hypoparathyroidism. 544 patients from 63 regions of the Russian Federation were included in this study.ResultsThe majority of cases had postsurgical etiology (88.4%). Postsurgical hypoparathyroidism prevailed in females (р&lt;0.001). About a half of patients had blood calcium and phosphorus targets, 56 and 52% respectively. Nephrolithiasis was confirmed in 32.5%, nephrocalcinosis - in 12.3% of cases. The risk of nephrocalcinosis/nephrolithiasis increased by 1.85 times with disease duration more than 4.5 years. The cataract was found in 9.4%. The cut-off point for the development of cataracts was 9.5 years, with a 6.96-fold increased risk. The longer duration of hypoparathyroidism of any etiology was associated with more frequent cataract (p=0.0018).We found brain calcification in 4%, arrhythmias in 7.2% and neuropsychiatric symptoms in 5.15% of cases. Generally, the BMD in the studied group corresponded to age values, and there was no evidence for the phenomenon of high bone density. TBS was consistent with normal bone microarchitectonics. In our study, the majority of patients (83.5%) was treated with standard therapy of calcium and vitamin D supplements. 5 patients with severe disease course were treated with rhPTH (1–34).ConclusionsAnalysis of the presented database indicates insufficient diagnosis of the complications associated with chronic hypoparathyroidism. Overall, hypoparathyroidism is associated with higher risks of renal stone formation, decreased GFR, cataract especially in patients with longer duration of disease.
Clinical Characteristics of Short-Stature Patients With Collagen Gene Mutation and the Therapeutic Response to rhGH
Authors: Chen Meiping , Miao Hui , Liang Hanting , Ke Xiaoan , Yang Hongbo , Gong Fengying , Wang Linjie , Duan Lian , Chen Shi , Pan Hui , Zhu Huijuan 
Published: February 2022

ContextClinical genetic evaluation has been demonstrated as an important tool to elucidate the causes of growth disorders. Genetic defects of collagen formation (the collagenopathies) have been reported to be associated with short stature and skeletal dysplasias. Etiological diagnosis of skeletal abnormality-related short stature is challenging, and less is known about recombinant human growth hormone (rhGH) therapy.ObjectiveThis is a single-center cohort study which aims at exploring the genetic architecture of short-stature children with skeletal abnormalities and evaluating the frequency of collagenopathies to determine their phenotype, including the rhGH treatment response.Patients and MethodsOne hundred and six children with short stature and skeletal abnormalities were enrolled who were evaluated by next-generation sequencing (NGS) to detect variants in the skeletal collagen genes including COL1A1, COL1A2, COL2A1, COL9A1, COL9A2, COL9A3, COL10A1, COL11A1, and COL11A2. The results were evaluated using American College of Medical Genetics and Genomics (ACMG) guidelines. Clinical characteristics and rhGH treatment response were summarized.ResultsTwenty-four pathogenic or likely pathogenic variants of collagen genes were found in 26 of 106 (24.5%) short-stature patients with skeletal abnormalities, of which COL2A1 mutations were the most common, accounting for about 57.7%. Other frequent mutations associated with skeletal development include FGFR3, ACAN, NPR2, COMP, and FBN1 in 12.2%, 0.9%, 0.8%, 0.4%, and 0.4%, respectively, resulting in significantly different degrees of short stature. An overview of clinical features of collagenopathies showed growth retardation, skeletal abnormalities, and heterogeneous syndromic abnormalities involving facial, eye, hearing, and cardiac abnormalities. The average height of 9 patients who received rhGH treatment improved from a median of -3.2 ± 0.9 SDS to -2.2 ± 1.3 SDS after 2.8 ± 2.1 years. The most significant height improvement of 2.3 SDS and 1.7 SDS was also seen in two patients who had been treated for more than 6 years.ConclusionsA proband-based NGS revealed that distinct genetic architecture underlies short stature in varying degrees and clinical features. Skeletal abnormality-related short stature involving multiple systems should be tested for skeletal collagen gene mutation. Limited rhGH treatment data indicate an improved growth rate and height, and close monitoring of adverse reactions such as scoliosis is required.
Applicability of Flow Resistance Formulae for Sand-Bed Channels: An Assessment Using a Very Large Data Set
Authors: Peng Hao , Huang He Qing , Yu Guoan , Zhang Hongwu 
Published: February 2022

Among numerous flow resistance formulae for sand-bed channels, this study selected five for evaluation and in order to cover flow conditions in sand-bed river channels as widely as possible, a total of 1,636 sets of field measures were collected from the hydrological stations of two large river systems of China—the Yellow and Yangtze Rivers, in addition to the data compiled by Brownlie. The performance of the selected formulae in yielding the values of Manning resistance coefficient n was evaluated against the total of 6,805 datasets. In many cases, the formula of Ma et al. yielded unreasonable n values of &lt;0, while that of Deng et al. and formulae 1 and 2 of Zhang et al. yielded n values with large errors. The formula of Wu and Wang yielded n values varying within the scope only in the case of n &lt; 0.04. By dividing the absolute relative errors (AREs) from the selected formulae into six groups of 0–0.05, 0.05–1, 0.1–0.2, 0.2–0.5, 0.5–1, and &gt;1, it can be found that, for all five selected formulae, ARE occurred in the group 0.2–0.5 occupied the largest percentage, while in each of the adjacent groups of 0.5–1 and 0.1–0.2 it also occupied a very large percentage. Hence, all five formulae still need to improve their predicting ability.