bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of the Rox index to predict High Flow Nasal Cannula failure in COVID-19 patients.
Authors: Tlili Badis , Trifi Ahlem , Mehdi Asma , Abdennebi Cyrine , Daly Foued , Abdellatif Sami , Touil Yosr , Lakhal Salah Ben 
Published: June 2022

Abstract
Background
While High Flow Nasal Cannula (HFNC) use increased in COVID-19 hypoxic patients, the optimal timing of mechanical ventilation in COVID-19 is uncertain. We sought to evaluate the ROX index ([SpO2/FIO2]/breathing frequency) capacity to predict weaning from high-flow nasal cannula (HFNC) in COVID-19.
Methods
We performed a single-center, retrospective, observational study of subjects with respiratory failure from COVID-19 managed with HFNC. The ROX index was calculated at H 12 from HNFC and applied to predict HFNC failure. Subjects managed with HFNC were divided into two groups. And HFNC failure was defined as endotracheal intubation and invasive ventilation necessity in the first five days from admission. Standard statistical comparisons and regression analyses were used to evaluate the ROX index performance in prediction of HFNC failure.
Results
121 subjects with COVID-19 were managed with HFNC. 66 (55.5%) were successfully weaned from HFNC and 55 (45.5%) required intubation and mechanical ventilation. High mortality rates have been reported in the last group. Rox index < 2.8, a severe ARDS at admission and the occurrence of an acute cor pulmonale were independent risk factors of HFNC failure. The performance of a ROX index at H12 lower than 2,8 was significant (AUC = 0,621; 95% CI: 0,520-0,722) to predict a HFNC failure.:
Conclusion
In this retrospective review, HFNC success was associated to better clinical outcome. The ROX index was sensitive to predict HFNC failure and may allow better patient’s selection and earlier invasive mechanical ventilation initiation to optimize patient’s outcome.
Recovery of visual field after awake stimulation mapping of the optic pathway in glioma patients
Authors: Ichinose Toshiya , Kinoshita Masashi , Nakajima Riho , Tanaka Shingo , Nakada Mitsutoshi 
Published: June 2022

Abstract
Brain mapping during awake craniotomy for gliomas can help preserve neurological functions, including maintenance of central and peripheral vision. However, the consecutive changes in the visual field remain unknown. We retrospectively assessed 14 patients who underwent awake craniotomy for gliomas infiltrating into the optic radiation. Cortico-subcortical direct electrical stimulation (DES) was intraoperatively applied until transient visual symptoms were elicited and recorded. The visual fields were examined consecutively in the preoperative period and postoperative subacute and chronic periods. To evaluate the anatomo-functional validity of the recordings, all DES-elicited points were overlaid onto a three-dimensional template that included the optic radiation, using voxel-based morphometry (VBM) mapping. All patients experienced visual symptoms that were classified as phosphenes, blurred vision, or hallucinations during DES, and surgical resection was limited to within the functional boundaries. In VBM, almost all the subcortical positive mapping points overlapped with the surface of the optic radiation, and the distribution of sites that induced visual phenomena in the upper or lower visual fields could be differentiated in the anatomical space. We observed no postoperative visual deficit in four patients (29%), time-dependent improvements in five out of eight patients that presented transient quadrantanopia or partial visual defect (36% out of 57%), and permanent hemianopsia (14%) in two patients with occipital lesions. Intraoperative DES that identifies and preserves optic radiation in awake craniotomy for gliomas is a reliable and effective technique to avoid permanent deficit, but has a low success rate in patients with occipital involvement.
The Feasibility and Efficacy of Computer-assisted Screw Inserting Planning in the Surgical Treatment for Severe Spinal Deformity: a prospective study
Authors: Zhang Yiqi , Hai Yong , Yang Jincai , Yin Peng , Han Chaofan , Liu Jingwei , Zhou Lijin 
Published: June 2022

Abstract
Background: The objective of the study was to explore the feasibility and efficacy of computer-assisted screw inserting planning (CASIP) in the surgical treatment for severe spinal deformityMethods: A total of 50 patients participated in this prospective cohort study. 25 patients were allocated into CASIP group and 25 patients were in Non-CASIP group. The demographic data, radiological spinal parameters were documented and analyzed. Each pedicle screw insertion was classified as satisfactory insertion or unsatisfactory insertion based on Gertzbein-Robbins classification. The primary outcome was the accuracy of pedicle screw placement. The secondary outcomes were the rate of puncturing screws, estimated blood loss, surgical time, correction rate and other radiological parameters.Results: A total of 45 eligible patients completed the study, and 20 patients were in CASIP group and 25 patients were in Non- CASIP group. The accuracy of pedicle screws placement in CASIP Group and Non-CASIP Group were (92.0±5.5) % and (82.6±8.3) % (P<0.05), and the rate of puncturing screws were (0 (0-0)) % and (0 (0-6.25)) % (P<0.05). The median surgical time were 280.0 (IQR: 260.0-300.0) min and 310 (IQR: 267.5-390.0) min in two group and showed significant statistic difference (P<0.05). Conclusion: CASIP has good feasibility and can gain a more accurate and reliable instruments fixation, with which spine surgeons can make a detailed and personalized screw planning preoperatively to achieve satisfying screw placement.
Landslide mechanism and stability of an open-pit slope: The Manglai open-pit coal mine
Authors: Chen Tao , Shu Jisen , Han Liu , Li Baosheng 
Published: June 2022

Abstract

A clear understanding of landslide mechanisms and stability analyses is of great significance for landslide monitoring, prediction, and control. A large-scale end wall landslide occurred on August 7–20, 2020, in the Manglai open-pit coal mine, China. In this paper, the engineering geological survey, mechanical test, large-deformation finite element numerical method, limit equilibrium method and analytical formula are used to analyze how the groundwater level rise caused this end wall failure and landslide. First, the engineering geological conditions, hydrogeological conditions, landslide activity signs and physical and mechanical parameter calibration of the sliding mass are investigated in detail and tested, mainly including the rock distribution, lithologic characteristics, structure, fault, cumulative rainfall, groundwater level burial depth, water inflow, landslide process and testing of mechanical parameters such as cohesion and internal friction angle of the sliding mass. Second, three-dimensional and two-dimensional numerical models of slopes are established, and an analytical formula calculation method to calculate the factor of safety (FoS) is proposed when sliding cracks are located on the top and toe of a slope. Finally, the causes of the landslide, mechanism and stability are analyzed and discussed. The results indicate that the fault fracture zone, soft strata, continuous heavy rainfall, and groundwater were the main contributors to this landslide. The three-dimensional numerical calculation results are consistent with the deformation and failure process of the slope observed in the field, which shows a retrogressive progressive failure mode. The calculation results of SLOPE/W and the analytical formula are consistent; i.e., when the groundwater level rises to + 950, the stability of the end wall reaches the critical stability state. With the passage of time, the creep of the sliding surface accelerates until the entire end wall landslide.
Reduced Order Synchronization of Two Non-identical Special Class of Strict Feedback Systems via Back-stepping Control Technique
Authors: Bora Riddhi Mohan , Sharma Bharat Bhushan 
Published: June 2022

Abstract
In this paper, we have addressed a ROS (Reduced Order Synchronization) problem of two general classes of chaotic or hyperchaotic systems in master (drive) and slave (response) configuration. The master and the slave systems are considered to follow a very specific form of structure; so-called the strict-feedback form. Being a ROS problem, the order of the master system is naturally greater than that of the slave system. But we have taken a particular case where the order difference between both the systems is one. A systematic nonlinear back-stepping control design methodology is developed so to attain the reduced-order synchronization goal. In real practice, only [[EQUATION]] number of states of the response system get synchronized with [[EQUATION]] states of the drive system, incorporating [[EQUATION]] amount of controllers, having considered the order of the drive and response system to be [[EQUATION]] and [[EQUATION]] (and [[EQUATION]] ), respectively. It is shown that, unlike other existing conventional nonlinear control techniques, the back-stepping method requires only a single scalar controller [[EQUATION]] [[EQUATION]][[EQUATION]] to achieve the same task mentioned above. The question arises, what will happen to the [[EQUATION]] state of the master system. Being a chaotic system, it can be said that [[EQUATION]] state will be bounded in nature. But, its stability can not be guaranteed. By appending an extra [[EQUATION]] dynamics to the slave system and adding a suitable nonlinear active controller [[EQUATION]] [[EQUATION]] can tackle the stability challenge of the [[EQUATION]] state, as stated earlier. A sound generalization of the control function [[EQUATION]] and [[EQUATION]] have also been included in the discussion. To prove the asymptotic stability of the error dynamics of the system, the Lyapunov stability direct method has been utilized. Extensive MATLAB simulation results verify the theoretical findings.
Cannabidiol improves fish welfare
Authors: Camargo-dos-Santos Bruno , Bellot Marina Sanson , Guermandi Isabela Inforzato , Favero-Neto Jõao , Rodrigues Maira da Silva , Costa Daniel Fernandes da , Nóbrega Rafael Henrique , Filev Renato , Gonçalves-de-Freitas Eliane , Giaquinto Percília Cardoso 
Published: June 2022

Abstract
Cannabidiol (CBD) is a substance derived from Cannabis sativa, widely studied in medicine for controlling neural diseases in humans. Besides the positive effects on humans, it also presents anxiolytic proprieties and decreases aggressiveness and stress in mammals. Therefore, CBD has the potential to increase welfare in reared animals, as it seems to reduce negative states commonly experienced in artificial environments. Here, we tested the effect of different CBD doses (0,1,10, and 20 mg/kg) on aggressiveness, stress, and reproductive development of the Nile tilapia (Oreochromis niloticus) a worldwide fish reared for farming and research purposes. CBD mixed with fish food was offered to isolated fish for 5 weeks. The 10 mg/kg dose decreased fish’s aggressiveness over time, whereas 20 mg/kg attenuated non-social stress. Both doses decreased the baseline cortisol level of fish and increased the gonadosomatic index. However, CBD 1 and 10 mg/kg doses decreased the spermatozoa number. All CBD doses did not affect feeding ingestion and growth variables, showing that it is not harmful to meat production amount. Despite the effect on spermatozoa, CBD supplementation exhibits high potential to benefit animals’ lives on an integrative-based welfare approach. Therefore, we showed for the first time that CBD could be used as a tool to increase non-mammal welfare, presenting a great potential to be explored in other husbandry and captivity species.
WITHDRAWN: Risk factors of cardiovascular diseases of individuals with type 2 diabetes mellitus, knowledge levels and affecting factors
Authors: Gök Fadime 
Published: June 2022

Abstract
Background
The aim of this study was to determine the cardiovascular disease risk factors knowledge levels of individuals with Type 2 diabetes mellitus and the affecting factors.
Methods
Data were collected from 207 patients (101 men; 106 women) diagnosed with Type 2 Diabetes, who came to the Endocrinology outpatient clinic for control purposes between September 2021 and February 2022.
Results
The mean age of individuals with type 2 diabetes mellitus is 60.99 ± 13.74 years, and they have been diabetic for an average of 12.22 ± 9.86 years. The mean total score of the cardiovascular diseases risk factors knowledge scale was found to be 17.90 ± 3.33. It was determined that there was a statistically significant relationship between the sociodemographic characteristics of the patients and some of the variables related to heart health-protective behaviors and the level of knowledge of cardiovascular risk factors (p < 0.05).
Conclusion
The cardiovascular disease risk factors knowledge level of the patients included in the study was higher than the limit. The level of knowledge of the patients who exercise, have a balanced diet, and have cardiovascular health checks is higher than the others.
Prediction of Intraductal Carcinomas of the Breast That Will Not Evolve to Invasive Carcinomas.
Authors: Vilardell Felip , Iglesias Edelmiro , Canosa Carles , Urdanibia Izaskun , Martínez Montserrat 
Published: June 2022

Abstract
Ductal carcinoma in situ (DCIS) of the breast is a malignant neoplastic proliferation of cells with a ductal phenotype, which is confined to the epithelial compartment of ducts and acini. DCIS is regarded as a nonobligate precursor of invasive ductal carcinoma (IDC) of the breast. Currently it is not possible to predict which DCIS will progress to IDC, and so the vast majority of patients with DCIS undergo surgical resection and radiation therapy. DCIS and IDC share most of the genetic alterations, including somatic mutations, genetic expression profiles and genetic copy number alterations. Our aim was to find a genetic mutational profile that could help to predict which DCIS will progress to IDC and which will not. Individuals with a predicted probability of DCIS synchronous with IDC of 0.5 or lower were found to be those with a mutation in 38138689 (POSTN), and no mutation in either 151851109 (KMT2C), 187524525 (FAT1) or 55139771 (PDGFRA).
Long-term Outcomes in Patients with Adult-Onset Craniopharyngioma
Authors: Dogra Prerna , Bedatsova Lucia , Gompel Jamie J. Van , Giannini Caterina , Donegan Diane M. , Erickson Dana 
Published: June 2022

Abstract
Purpose
Craniopharyngiomas are nonmalignant sellar and parasellar tumors exhibiting a bimodal age distribution. While the outcomes following treatment in patients with childhood-onset craniopharyngiomas are well characterized, similar information in adult-onset craniopharyngiomas is limited. We aimed to describe the long-term outcomes (weight and metabolic parameters, mortality) in patients with adult-onset craniopharyngioma following treatment.
Methods:
Patients with adult-onset craniopharyngioma with initial treatment (1993–2017) and > 6 months of follow-up at our institution were retrospectively identified. Body mass index (BMI) categories included obese (BMI ≥ 30 kg/m2), overweight (BMI 25-29.9 kg/m2), and normal weight (BMI < 25 kg/m2).
Results
For the 91 patients with adult-onset craniopharyngioma (44% women, mean diagnosis age 48.2 ± 18 years) over a mean follow-up of 100.3 ± 69.5 months, weight at last follow-up was significantly higher than before surgery (mean difference 9.5 ± 14.8 kg, P < 0.001) with a higher percentage increase in weight seen in those with lower preoperative BMI [normal weight (20.7 ± 18%) vs. overweight (13.3 ± 18.0%) vs. obese (6.4 ± 15%), P = 0.012. At last follow-up, the prevalence of obesity (62 vs. 40.5%, P = 0.0042) and impaired glucose metabolism (17.4% vs. 34%, P = 0.017) increased significantly. All-cause mortality was 12%, with the average age of death 71.9 ± 19.7 years (average U.S. life expectancy 77.7 years, CDC 2020).
Conclusion
Patients with adult-onset craniopharyngioma following treatment may experience weight gain, increased prevalence of obesity, impaired glucose metabolism, and early mortality. Lower preoperative BMI is associated with a greater percentage increase in postoperative weight.
The metabolic regulator USF1 is involved in the control of affective behaviour in mice
Authors: Pollak Daniela , Sideromenos Spyros , Nikou Maria , Czuczu Barbara Czuczu , Thalheimer Nikolas , Gundacker Anna , Horvath Orsolya , Rico Laura Cuenca , Stöhrman Peter , Niello Marco , Partonen Timo 
Published: June 2022

Abstract
Epidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, and mood disorders, most prominently major depression. However, the biological mechanisms mediating the comorbid relationship between the deranged metabolic and mood states remain incompletely understood.Here we tested the hypothesis that the enhanced activation of brown fat tissue (BAT), known to beneficially regulate obesity and accompanying dysfunctional metabolic states, is also paralleled by an alteration of affective behaviour. We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits, and we found a reduction of depression-like and anxiety-like behaviours associated with USF1 deficiency. Surgical removal of interscapular BAT did not impact the behavioural phenotype of USF1 KO mice. Further, the absence of USF1 did not lead to alterations of adult hippocampal neural progenitor cell proliferation, differentiation, or survival. RNAseq analysis characterized the molecular signature of USF1 deficiency in the hippocampus and revealed a significant increase in the expression of several members of the X-linked lymphocyte-regulated (xlr) genes, including xlr3b and xlr4b. Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. These molecular changes were associated with morphological alterations in hippocampal neurons, manifested in reduced dendritic length and complexity.Collectively these data suggest that the metabolic regulator USF1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF1-dependent BAT activation, but instead reflected in structural changes in the brain.
Intramuscular Mitochondrial Adaptation and Lipid Metabolic Alteration in Rats after Chronic High-intensity Interval Training (HIIT) of Different Training Periods
Authors: Shangguan Ruonan , Hu Zhiqiang , Luo Yuzhen , Chen Min , Sun Jingquan , Chen Siyu 
Published: June 2022

Abstract
Background : High-intensity Interval Training (HIIT) is a time-efficient form of exercise and has gained popularity in recent years. However, at molecular level, the understanding about the effects of HIIT is not comprehensive, and even less is elucidated about HIIT of different training duration cycles, although different durations always lead to different post-training consequences. Method: In this study, by training SD rats using HIIT protocols lasting for different training duration cycles, we investigated the adaptive response of intramuscular triglyceride abundance and mitochondria enhancement after HIIT training (2, 4, 6, 8, and 10 weeks). We selected 72h after the last session of training as the time point of sacrifice. Results: The suppressed activation of the cAMP-PKA pathway indicates that skeletal muscle was in the recovery phase at this time point. Intramuscular triglyceride abundance was significantly elevated after 2, 4, and 10 weeks of HIIT. However, the lipid metabolism-related proteins inconsistently changed in a chaotic trend (see Table. 1). The expression levels of PGC1-α and COX IV decreased after 2 and 4 weeks of training and began to rise when the training duration reached 6 weeks. Interestingly, the variation tendency of PGC1-α and COX IV is very similar to that of CPT-1B. Conclusion: Given the fact that CPT-1B is responsible for the transfer of free fatty acids into the mitochondria to facilitate muscular lipid oxidation, there is a great possibility that: A) the IMTG accumulation observed within 0-4 weeks [defined as phase 1 here] of HIIT might be primarily attributed to damaged mitochondria oxidation capacity. B) when the training duration reached 6 weeks [defined as phase 2], mitochondria function and biogenesis began to be improved by training stimulus and might result in the disappearance of IMTG increase. We believe the phase 2 is rather similar to the condition of athletes` paradox, which should be a healthy adaptation induced by exercise training. Also, for HIIT Rat Modelling, intervention duration cycles longer than 4 weeks are recommended if similar HIIT frame of this study is used.
Seismic Vulnerability Assessment of Reinforced Concrete Buildings Having Nonlinear Fluid Viscous Dampers
Authors: Mokhtari Mehdi , Naderpour Hosein 
Published: June 2022

Abstract
Seismic resilience is the residual capacity of a damaged system for recovering and sustaining an acceptable level of performance as a consequence of a seismic event. Firstly, this paper summarizes the current calculation framework of seismic resilience using fragility analyses. After that, a new metric based on vulnerability analyses is developed to calculate seismic resilience. Finally, a typical hospital building is adopted as a single building and then retrofitted with supplemental Energy Dissipation Systems (EDS) to show the applicability of the new metric and compare it with the current calculation model of the seismic resilience. The considered supplemental EDS is the Nonlinear Fluid Viscous Damper (NFVD) located as the diagonal damper-brace system. The seismic performance of the supplemental EDSs is to enhance structural performance by reducing induced lateral displacements and as a result the level of physical damages and losses. To this end, Incremental Dynamic Analysis (IDA) is implemented to achieve the damage fragility and vulnerability curves. A comparison of the fragility, vulnerability, and functionality curves indicates that NFVDs are potentially useful for attenuating seismic damages to structural and non-structural components.