bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelium is the main target of coronavirus infection
Authors: Bondar M.V. , Pylypenko M.M. , Loskutov O.A. 
Published: May 2022

BACKGROUND. The world currently has a huge clinical experience in the treatment of SARS-CoV-2 infection. However, emerging scientific data opens up new information on the manifestations of coronavirus disease (COVID-19) and its consequences, which can affect both the changes of its clinical picture and the quality of patients’ life.
OBJECTIVE. To summarize the results of literature search and own experience of intensive care of endothelial dysfunction in COVID-19.
MATERIALS AND METHODS. The work is based on the results of an internet search with a help of Google and PubMed using the following key words: “intensive care of SARS-CoV-2”, “pathophysiological changes in coronavirus infection”, and “endothelial dysfunction”.
RESULTS. This review describes the links of COVID-19 pathogenesis, mechanisms of viral endothelial damage and hypercoagulopathy, and the main directions of prevention and treatment of endothelial dysfunction.
CONCLUSIONS. SARS-CoV-2 infection promotes endotheliitis in various organs as a result of viral infection. The presence of COVID-19-induced endotheliitis can explain the systemic microcirculation disorders in various vascular beds and their clinical consequences.
Journey to Unknown
Authors: Simsek Cansu Nur 
Published: May 2022

Abdullah Karam, who escapes the Syrian Civil War in 2014, transforms the difficult migration and escape process he experienced into an autobiographical adventure game with Path Out (2017). The aim of the article is to examine the gamification of this escape process as a critical game design. Also, the article assesses Path Out (2017) as an interactive counter documentary as the inserted video clips by Karam foster a mode of listening to the experience from the first hand. The article analyzes the game with the close reading technique and the researcher uses her own observations and experiences as a player.
With the concept of critical play, Mary Flanagan points out that a game can interact with important social issues, such as immigration and war. Accordingly, as a critical play, Path Out (2017) enables the players to have knowledge of socio-political realities and cultural dynamics and to become conscious by following the experiences of a civilian and young individual during the civil war. Thus, can games be an alternative method of documenting real-life events? Or can the plays reveal the subjective aspects of the documentary and criticize the genre?
The article examines the short videos that Karam has embedded in the game, reminding of the live and interactive game commentary. Karam's in-game interventions allow the player to connect and criticize both reality and the virtual environment in the game. The video method used in the game documents Karam's memories and experiences as a counter mode of archiving. With these self-recorded video interventions, Karam comments on themes such as war, displacement, identity, death, family, and daily life, and gives information to the player. Karam wears the same sweatshirt as the character in the game world and calls out directly to the players, "You are playing me in this game". Thus, the physical separation between the players and the game character becomes evident with the appearance of Karam. The game Path Out (2017) becomes a useful tool for Karam to tell his story with his own voice. Making oneself visible and audible are key positions Karam takes regarding exposure to displacement. To put it in Flanagan's words, Path Out (2017) can also function as a tool to understand the players themselves.
With the crossing of the border in the last part of the game, Karam tries not to get caught in the mines and not to be killed by the border troops. The game ends when Karam successfully crosses the border. However, each time the player dies, they get a new chance to cross the border because the real Karam is alive, and dead at the border of the game is experienced temporarily. For this reason, the player's desire to play again turns into an uneasy experiment. The dark atmosphere of the border evokes the unknown after crossing the border. Besides, with each experience of temporary death in the game, players are encouraged to rethink the issue of numerous and out-of-the-record migrant deaths passing the borders.
Korsakow Film Workshop
Authors: Thalhofer Florian , Wiehl Anna 
Published: May 2022

Based on the premise that Korsakow configurations are not merely another form of interactive film, we will explore the entanglement of the epistemological and ontological dimension of this unorthodox manifestation of digital media practices based on database logic and opaque algorithmic editing.
This workshop explores non-linear thinking, co-creative, polyphonic filmmaking and pluri-perspective self-reflection to those interested in pushing further the boundaries of linear filmmaking. The goal of this workshop is to re-think processes of interactive filmmaking as well as notions of interactive tools in their ‘toolness,’ and methods concerning their applicability as lenses through which we reflect on the work of others and our work. Though we will collaboratively create an interactive Korsakow film, the focus of this workshop primarily lies in the process rather than a product.
No prior knowledge nor specific technical skills are required as one of the core realizations will be that these practices can be integrated into vernacular life. The only digital device participants will need is their smartphone for shooting the clips.
ЦЕНТРАЛЬНИЙ НАУКОВО-ДОСЛІДНИЙ ІНСТИТУТ ЗБРОЙНИХ СИЛ УКРАЇНИ НА ЧОЛІ ВОЄННОЇ НАУКИ: ОСНОВНІ ЗДОБУТКИ ПЕРІОДУ 2014–2021 РОКІВ
Authors: Романченко Ігор 
Published: May 2022

У статті розглянуто історію створення, 30-річного функціонування та наукових здобутків Центрального науково-дослідного інституту Збройних Сил України — провідної науково-дослідної установи Збройних Сил України.
Висвітлено основні підсумки наукової діяльності інституту з 1992 року, більш докладно — від початку військової агресії РФ у 2014 році і понині щодо:
розроблення та впровадження доктринальних документів Збройних Сил;
воєнної безпеки держави, оборонного планування;
визначення та обґрунтування потреб Збройних Сил України, розподіл та використання державних коштів;
уточнення цілей та засад державної політики у сферах національної безпеки і оборони;
ролі територіальної оборони та руху опору в системі застосування сил оборони України;
пріоритетних напрямів розвитку ОВТ Збройних Сил України;
єдиної структури системи керівництва обороною держави і управління військами та створення ЄАСУ;
розвитку системи логістичного забезпечення та покращення обліку військового майна;
комплексу математичних моделей операцій з обґрунтування задумів та планів у галузях будівництва, застосування та забезпечення ЗС України тощо.
Висвітлено наукові школи та провідних науковців інституту.
Ключові слова: Центральний науково-дослідний інститут Збройних Сил України, напрями досліджень, наукова діяльність, наукове супроводження, впровадження результатів досліджень, наукові здобутки, висококваліфіковані науковці.
ЕКСПОЗИЦІЯ НАЦІОНАЛЬНОГО ВІЙСЬКОВО-ІСТОРИЧНОГО МУЗЕЮ УКРАЇНИ ЯК ВТІЛЕННЯ СУЧАСНОЇ ДЕРЖАВНИЦЬКОЇ КОНЦЕПЦІЇ ВІЙСЬКОВОЇ ІСТОРІЇ УКРАЇНИ
Authors: Ільєнко Андрій , Шупік Євгеній , Шатілов Євгеній 
Published: May 2022

У даній статті автори аналізують структуру і наповнення експозиції Національного військово-історичного музею України (НВІМУ) у контексті відповідності актуальній державницькій концепції української військової історії та її практичного значення у сфері національно-патріотичного виховання військовослужбовців та молоді. Дослідники розглянули роль і значення музейних установ сучасної України в цілому, акцентуючи увагу на особливій ролі військових музеїв у сфері національно–патріотичного виховання. Визначено, що в експозиції музею втілено національні і державницькі підходи до військової історії України, висвітлено ключові етапи військового будівництва крізь призму українського державотворення.
Ключові слова: музей, НВІМУ, воєнна історія, експозиція, Українська революція, АТО, ООС, збройний конфлікт на Сході України.
ВІД ГРОМАДСЬКИХ ІНІЦІАТИВ ДО ЗАКОНОДАВЧИХ АКТІВ ВЕРХОВНОЇ РАДИ: ПЕРЕДІСТОРІЯ СТВОРЕННЯ ЗБРОЙНИХ СИЛ УКРАЇНИ
Authors: Сегеда Сергій , Шевчук Василь , Покотило Олексій , Чайковський Анатолій 
Published: May 2022

У статті простежуються передумови творення українського національного війська напередодні розпаду СРСР та його перші роки існування незалежної держави України. Аналізуються військово-політичні обставини і їх вплив на створення Збройних Сил України. На території УРСР розміщувався один із найпотужніших контингентів Радянської армії, яка фінансувалася з союзного бюджету. З’ясовується поступовий перехід від сприйняття війська як оплоту тоталітаризму до розуміння необхідності цього державного інституту. Проводяться паралелі між способами творення власного війська у країнах Прибалтики та в Україні, зокрема вплив громадсько-політичних рухів на цей процес. Аналізується хронологія формування законодавчої бази поетапного перетворення військових угруповань радянських військ, що дислокувалися на території республіки, у Збройні Сили України.
Ключові слова: Збройні Сили України, антиармійські громадські рухи,
Спілка офіцерів України, законодавчі акти.
ФОРМУВАННЯ ТА ЕТАПИ РОЗВИТКУ ЗАЛІЗНИЧНИХ ВІЙСЬК НА ТЕРИТОРІЇ УКРАЇНИ
Authors: Остапенко Ігор , Гудімов Віктор 
Published: May 2022

У статті розглядаються і досліджуються особливості періодів фор- мування та розвитку військових залізничних формувань на території України. Було визначено 10 основних етапів розвитку: утворення і ста- новлення у імперський період, участь у Першій світовій та Громадян- ській війнах, формування нових радянських залізничних формувань, участь у Другій світовій війні, участь у відбудові країни, розвиток радянської інфраструктури та подолання наслідків природних катаклізмів та тех- ногенних аварій, розвиток інфраструктури незалежної України та подо- лання наслідків природних катаклізмів, криза залізничних військ та ство- рення Держспецтрансслужби, розвиток інфраструктури та подолання наслідків природних катаклізмів у складі Держспецтрансслужби, участь Держспецтрансслужби у відбитті збройної агресії Російської Федерації та повернення її до Міністерства оборони України.
Ключові слова: історія, Державна спеціальна службу транспорту, залізничні війська, операція Об’єднаних сил, залізниця, транспортна інфра- структура.
Internal Genital Organ-preserving Radical Cystectomy: A Case Report
Authors: WIDIA FINA , SITUMORANG GERHARD R , HAMID AGUS RIZAL A.H , MOCHTAR CHAIDIR A 
Published: May 2022

ABSTRACTAdenocarcinoma of the bladder is usually managed by radical cystectomy. However, recent literature shows that internal genital organ-preserving radical cystectomy is feasible in selected cases in order to get a better impact on patient’s psychology, sexuality and potential fertility. Here, we report a 32-year-old woman with adenocarcinoma of the bladder who was managed with internal genital organ-preserving radical cystectomy. The patient was never had any child and the radiologic examination (MRI) showed no involvement of internal genitalia organ. This procedure aims to maintain fertility potential of the patient. Intraoperatively, no adhesion was found between the tumor and internal genitalia organ. The internal genitalia organ was successfully preserved during the radical cystectomy. ABSTRAKTata laksana adenokarsinoma kandung kemih umumnya berupa sistektomi radikal. Akan tetapi, penelitian terbaru menunjukkan bahwa preservasi organ internal genitalia dapat diterapkan pada kasus-kasus tertentu dengan tujuan untuk mempertahankan potensi seksual dan fertilitas pasien. Saat ini kami melaporkan seorang perempuan berusia 32 tahun dengan adenokarsinoma kandung kemih yang menjalani sistektomi radikal dengan tetap mempertahankan organ genitalia interna. Pasien merupakan nulipara dan pada pemeriksaan radiologi MRI tidak didapatkan infiltrasi tumor pada organ genitalia interna. Prosedur operasi dilakukan dengan tujuan mempertahankan potensi fertilitas. Intraoperatif, tidak didapatkan perlengketan antara tumor dan organ genitalia interna. Organ genitalia interna berhasil dipreservasi selama prosedur sistektomi radikal.
Subseasonal Reversal of Winter Temperature Over Northeast China in 2014/2015: Role of Arctic Sea Ice
Authors: Dai Haixia , Fan Ke 
Published: May 2022

This study investigates the temperature reversal over Northeast China (NEC) in winter 2014/2015, focusing on the variations of related general circulations and the affecting mechanisms of the Arctic sea ice on daily scale. It turns out to be the coupled impacts of the eastward propagations of tropospheric wave trains from the North Atlantic Ocean and the downward reflections of planetary wavenumber-1 from the stratosphere that resulted in the subseasonal reversal of winter temperature over NEC in winter 2014/2015. Also, such anomalous atmospheric circulations can be attributed to sea-ice anomalies over the Davis Strait–Baffin Bay (SIC-DSBB) and the Barents–Kara Sea (SIC-BKS) in November 2014. SIC-DSBB anomalies in November 2014 excited the eastward propagation of Rossby waves via the tripole pattern of sea surface temperature over the North Atlantic Sea, leading to the colder condition over NEC in the first and middle 10 days of December 2014. Anomalously heavy SIC-BKS also triggered wave trains from the polar region to Eurasia, strengthening the Rossby wave induced by SIC-DSBB. Moreover, the wave trains suppressed the upward propagation of planetary wavenumber-1 over the Siberia region, strengthening the stratospheric polar vortex. However, the sea-ice anomalies over these two domains only existed in November 2014. Thus, the tropospheric mechanisms by which the Arctic sea ice affected the temperature over NEC only lasted to late December 2014. Meanwhile, the stratospheric anomalies propagated downwards with the planetary wavenumber-1, favoring the positive phase of Arctic Oscillation in the troposphere and the warm condition over NEC since the last week of December 2014. Consequently, the temperature over NEC reversed in winter 2014/2015.
Characterization of Soil Pores Through X-Ray Computed Microtomography and Carbon Mineralization Under Contrasting Tillage and Land Configurations in the Indo-Gangetic Plains of India
Authors: Ghosh Tridiv , Maity Pragati Pramanik , Das T. K. , Krishnan P. , Chakraborty Debashis , Bhatia Arti , Ray Mrinmoy , Kundu Aditi , Bhattacharyya Ranjan 
Published: May 2022

Contrasting tillage and land configuration have important roles in porosity and pore size distribution (PSD), which in turn affects the carbon mineralization in soil. Information on the effects of these treatments on PSD and subsequent carbon mineralization is very limited. Hence, an attempt was made to evaluate the long-term impact of soil tillage and land configurations on the distribution of soil pores and its relationship with soil carbon mineralization under a maize (Zea mays)-wheat (Triticum aestivum) rotation. There were five treatments, that is, conventional tillage, (CT); permanent broad bed, (PBB); PBB + residue (R); zero tillage, (ZT); and ZT + R. Soil pores were quantified by X-ray computed tomography (μ-CT). The conversion of CT to ZT and PBB with or without residue retention (+R) resulted in the reduction of pores &gt;60 μm diameter and was mostly due to a reduction in the number of larger size macro-pores (&gt;110 μm). This resulted in restricted drainage. However, under these practices, pores with larger diameters (60–110 μm) facilitated soil aeration. The total organic carbon (TOC) was 15–48% and 17–47% higher under PBB, PBB + R, ZT, and ZT + R than that under CT in the 0–5 and 5–15 cm layers. The highest MWD (1.01 mm) was in the plots under PBB + R, and the lowest was in the CT plots, and all residue-retained plots (ZT + R and PBB + R) had a higher MWD than residue removal plots (ZT and PBB). Relative to CT, soil C mineralization rates in 0–5 and 5–15 cm soil depths were 63 and 55% higher in the alternate tillage practices, respectively, and the highest value occurred in PPB + R treatments. Increased labile C concentrations were indicative of greater mineralization and were correlated with pores &gt;60 μm, particularly in the size range 110–500 μm and TOC concentrations of 0–15 cm soil layer. Thus, the transition to alternate tillage from the conventional tillage enhanced soil organic carbon concentration (16–47.5%), improved soil structure, reduced the diameter of pores up to &gt;60 μm, and facilitated C mineralization by altering the pore size distribution of soil under a maize-wheat system in the IGP.
Case Report: Presence of Anti-MAG in the CSF Can Be Associated With a Neurodegenerative Process With Frontal Involvement
Authors: Dorcet Guillaume , Benaiteau Marie , Ory-Magne Fabienne , Blancher Antoine , Pariente Jérémie , Fortenfant Françoise , Bost Chloé 
Published: May 2022

BackgroundAutoimmune encephalitis (AIE) is an increasingly broad nosological framework that may clinically mimic neurodegenerative diseases (NDDs).Cases ReportedWe describe here the clinical, radiological, electrophysiological, and biological evolution of three patients. Two women aged 73 and 72 years and a 69-year-old man presented with complex cognitive and focal neurological symptoms and each had a predominant frontal dysexecutive involvement and an unexpectedly high titer of anti-MAG antibodies in the serum and cerebrospinal fluid (CSF). The question of an autoimmune cause was raised. After 2 years of follow-up and, for two of them, without improvement despite immunosuppressive treatments, diagnoses of NDD were eventually retained: post-radiation encephalopathy, progressive supranuclear palsy (PSP), and Alzheimer's disease.ConclusionThe presence of a high titer of anti-MAG antibodies may be found in NDD. It could reflect cerebral tissue damages, particularly in the case of significant frontal involvement. Atypical presentations may lead to a search for a paraneoplastic neurologic syndrome or AIE. However, the indirect immunofluorescence staining positivity on a monkey cerebellum section linked with anti-MAG antibodies should not lead to those diagnoses being retained.
miR-17-5p/HOXA7 Is a Potential Driver for Brain Metastasis of Lung Adenocarcinoma Related to Ferroptosis Revealed by Bioinformatic Analysis
Authors: Chen Quanfang , Pan Qingyun , Gao Han , Wang Yingju , Zhong Xiaoning 
Published: May 2022

ObjectivesPresent study aims to identify the essential mRNAs responsible for the development of brain neurovascular-related metastases (BNM) among lung adenocarcinoma (LUAD) patients. Further, we attempted to predict brain metastases more accurately and prevent their development in LUAD patients.MethodsTranscriptome data analysis was used to identify differentially expressed mRNAs (DEMs) associated with brain metastasis, and thereby the ferroptosis index (FPI) is calculated using a computational model. Meanwhile, the DEmRNAs linked with FPI, and brain metastasis were derived by the intersection of these two groups of DEMs. We also constructed a ceRNA network containing these DEmRNAs, identifying the HCP5 /hsa-miR-17-5p/HOXA7 axis for analysis. Further, a clinical cohort was employed to validate the regulatory roles of molecules involved in the ceRNA regulatory axis.ResultsHere we report the development of a ceRNA network based on BNM-associated DEMs and FPI-associated DEmRNAs which includes three core miRNAs (hsa-miR-338-3p, hsa-miR-429, and hsa-miR-17-5p), three mRNAs (HOXA7, TBX5, and TCF21), and five lncRNAs (HCP5, LINC00460, TP53TG1). Using gene set enrichment analysis (GSEA) and survival analysis, the potential axis of HCP5 /hsa-miR-17-5p/HOXA7 was further investigated. It is found that HOXA7 and ferroptosis index are positively correlated while inhibiting tumor brain metastasis. It may be that HCP5 binds competitively with miR-17-5p and upregulates HOXA7 to increase iron death limiting brain cancer metastasesConclusionsThe expression of both HOXA7 and HCP5 is positively correlated with FPI, indicating a possible link between ferroptosis and BNM. According to the results of our study, the ferroptosis-related ceRNA HCP5 /hsa-miR-17-5p/HOXA7 axis may contribute to the development of BNM in LUAD patients.
A Decrease in Hemodynamic Response in the Right Postcentral Cortex Is Associated With Treatment-Resistant Auditory Verbal Hallucinations in Schizophrenia: An NIRS Study
Authors: Liang Nana , Liu Sha , Li Xinrong , Wen Dan , Li Qiqi , Tong Yujie , Xu Yong 
Published: May 2022

BackgroundTreatment-resistant auditory verbal hallucinations (TRAVHs) might cause an increased risk of violence, suicide, and hospitalization in patients with schizophrenia (SCZ). Although neuroimaging studies have identified the neural correlation to the symptom of AVH, functional brain activity that correlates particularly in patients with TRAVH remains limited. Functional near-infrared spectroscopy (fNIRS) is a portable and suitable measurement, particularly in exploring brain activation during related tasks. Hence, our researchers aimed to explore the differences in the cerebral hemodynamic function in SCZ-TRAVH, patients with schizophrenia without AVH (SCZ-nAVH), and healthy controls (HCs), to examine neural abnormalities associated more specifically with TRAVH.MethodsA 52-channel functional near-infrared spectroscopy system was used to monitor hemodynamic changes in patients with SCZ-TRAVH (n = 38), patients with SCZ-nAVH (n = 35), and HC (n = 30) during a verbal fluency task (VFT). VFT performance, clinical history, and symptom severity were also noted. The original fNIRS data were analyzed using MATLAB to obtain the β values (the brain cortical activity response during the VFT task period); these were used to calculate Δβ (VFT β minus baseline β), which represents the degree of change in oxygenated hemoglobin caused by VFT task.ResultOur results showed that there were significant differences in Δβ values among the three groups at 26 channels (ch4, ch13-15, 18, 22, ch25–29, 32, ch35–39, ch43–51, F = 1.70 to 19.10, p &lt; 0.043, FDR-corrected) distributed over the prefrontal–temporal cortical regions. The further pairwise comparisons showed that the Δβ values of 24 channels (ch13–15, 18, 22, 25, ch26–29, ch35–39, ch43–49, ch50–51) were significantly lower in the SCZ group (SCZ-TRAVH and/or SCZ-nAVH) than in the HC group (p &lt; 0.026, FDR-corrected). Additionally, the abnormal activation in the ch22 of right postcentral gyrus was correlated, in turn, with severity of TRAVH.ConclusionOur findings indicate that specific regions of the prefrontal cortex may be associated with TRAVH, which may have implications for early intervention for psychosis.