bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrepancy of the subjective perception of the nasal appearance between independent individuals and patients undergoing functional rhinoplasty (fRPL)
Authors: Heiming Marleen , Savvas Eleftherios , Rudack Claudia , Stenner Markus , Spiekermann Christoph 
Published: June 2022

Abstract
Purpose
Satisfaction with the nasal appearance is a crucial outcome parameter in functional rhinoplasty (fRPL). The visual analogue scale is a suitable instrument not only for the preoperative patient assessment, but also as a patient-reported outcome measure in fRPL. In this study, we analyzed whether a high discrepancy in the preoperative subjective perception of the nasal appearance between patients and other individuals predicts a lower level of satisfaction with the postoperative result and hence a worse outcome of fRPL.

Methods
Standardized facial pictures of patients (n = 80) who underwent fRPL were taken preoperatively, 3 and 12 months postoperatively. In addition, patients were asked to complete the German version of the Utrecht Outcome Assessment Questionnaire in Aesthetic Rhinoplasty (D-OAR). The standardized facial pictures of the patients were presented to surgeons as well as to examiners without a medical background, and they were asked to evaluate the patients’ nasal appearance using the visual analogue scale.

Results
The external evaluation of patient’s nasal appearance was 1.7 points higher in median than the patient’s subjective perception (range −5.7–7.00). A large discrepancy between self- and external estimation significantly correlates with higher D-OAR values (r = 0.539, p < 0.001). Patients with high scores in the D-OAR trick questions, indicating a body dysmorphic disorder, show a significant larger discrepancy between the external- and the self-assessment (2.8 ± 0.5 vs. 1.4 ± 0.3, mean ± SEM, p = 0.017).

Conclusions
Large discrepancies between the self and external assessment of the nasal appearance are associated with a high-perceived influence of the appearance of the nose on the quality of life in patients undergoing functional rhinoplasty. That might be an indicator for unrealistic expectations concerning the postoperative outcome. Knowledge about this factor helps to identify the need for intensive discussion about possibilities and limitations of the planned procedure to avoid postoperative dissatisfaction.
Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma
Authors: Marchenko Sofya , Piwonski Iris , Hoffmann Inga , Sinn Bruno Valentin , Kunze Catarina Alisa , Monjé Nanna , Pohl Jonathan , Kulbe Hagen , Schmitt Wolfgang Daniel , Darb-Esfahani Sylvia , Braicu Elena Ioana , von Brünneck Ann-Christin , Sehouli Jalid , Denkert Carsten , Horst David , Jöhrens Korinna , Taube Eliane Tabea 
Published: June 2022

Abstract
Purpose
In recent years the tumor microenvironment and its interaction with the tumor has emerged into research focus with increased attention to the composition of Tumor-infiltrating lymphocytes. We wanted to quantify the composition of Regulatory T cells (Tregs) and T helper 17 cells (Th17 cells) and their prognostic impact in high-grade serous tubo-ovarian carcinoma.

Methods
Tregs and Th17 cells were determined by immunohistochemical analysis of CD25 FoxP3 and RORγt, respectively on tissue microarrays of a cohort of 222 patients with reviewed histology and available clinical data. Expression was analyzed with Qupath for quantification and integration with clinical data enabled calculation of prognostic impact. For validation FOXP3 and RORC mRNA expression levels from 502 patients with HGSC in publicly available datasets were evaluated.

Results
An average percentage of 0.93 Tregs and of 0.06 Th17 cells was detected per cells in overall tissue. Optimal cut-offs were determined and higher Tregs were associated with a better overall survival in stroma (p = 0.006), tumor area (p = 0.0012) and overall tissue (p = 0.02). After accounting for well-known prognostic factors age at diagnosis, residual tumor and FIGO stage, this association remained significant for stromal Tregs with overall survival (p = 0.02). Survival analysis for Th17 cells revealed no significant association with survival rates. Moreover, lower Th17/Treg ratios had a positive impact on patient overall survival (p = 0.025 tumor, p = 0.049 stroma and p = 0.016 overall tissue).

Conclusion
Our results outline a positive prognostic effect for higher Tregs but not for Th17 in high grade serous tubo-ovarian carcinoma.
Evaluation of the predictive values of elevated serum l-homoarginine and dimethylarginines in preeclampsia
Authors: Yuan Xiangmei , Cai Leiming , Hu Fengmei , Xie Li , Chen Xiong , Wu Jingjing , Li Qian 
Published: June 2022

Abstractl-homoarginine (hARG) is involved in nitric oxide biosynthesis, but its role and concentration in preeclampsia (PE) have not been fully revealed. The purpose of this study was to develop and validate a feasible clinical assay to quantify serum hARG, arginine (ARG), asymmetric (ADMA) and symmetric dimethylarginines (SDMA) levels by LC–MS/MS and investigate their differences at different stages of pregnancy with or without preeclampsia. Serum samples were collected from 84 pregnant women without complications (controls), 84 with mild preeclampsia (MPE), and 81 with severe preeclampsia (SPE) at various gestation stages (before the 20th week, during the 20th–28th week or after the 28th week of gestation). No significant difference in ARG levels was observed between PE and controls at any stage (P > 0.05). The serum hARG levels and hARG/ADMA ratios of MPE before the 20th week were higher than those of controls (P < 0.001). ADMA levels of MPE were higher than those of controls during the 20th–28th week (P < 0.01). SDMA levels of SPE were higher than those of MPE (P < 0.01) and controls (P < 0.05) after the 28th week. Elevated serum hARG before the 20th week was identified as an independent predictor for PE (OR = 1.478, 95% CI 1.120–1.950). ROC curve analysis showed serum hARG before the 20th week had a good potential to predict MPE (AUC = 0.875, 95% CI 0.759–0.948). In conclusion, our study indicated that elevated serum hARG and dimethylarginine levels detected by LC–MS/MS might serve as potential biomarkers for the early prediction of PE.
The impact of gender and sex on diagnosis, treatment outcomes and health-related quality of life in patients with axial spondyloarthritis
Authors: Marzo-Ortega Helena , Navarro-Compán Victoria , Akar Servet , Kiltz Uta , Clark Zoë , Nikiphorou Elena 
Published: June 2022

Abstract
Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic condition, historically considered a predominantly male disease. However, increasing evidence suggests a more equal prevalence between men and women. Of the limited research conducted to date, it is apparent that gender differences exist in terms of time to diagnosis, treatment outcomes and health-related quality of life (HRQoL). Despite this, women are underrepresented in clinical trials and most studies do not stratify by gender to identify potential differences in terms of disease manifestations and treatment response. In this perspectives article, we reflect on the potential biological and social factors contributing to these differences and propose three key areas of education and research that should be prioritised in order to address the unmet needs of female patients with axSpA, namely: (1) to identify ways to increase awareness of disease occurrence in female patients among healthcare professionals (HCPs), (2) to improve understanding of gender differences in disease manifestation and outcomes, and (3) to conduct gender-stratified clinical trials with a representative sample of female patients.
Attitudes towards climate migrants in Aotearoa New Zealand: the roles of climate change beliefs and immigration attitudes
Authors: Yates Olivia E. T. , Manuela Sam , Neef Andreas , Groot Shiloh 
Published: June 2022

Abstract
As the effects of climate change begin to materialise across Pacific Island nations, many exposed communities are considering migrating away from their homelands. Migrants’ resettlement experiences can depend upon their reception in the host nation. However, it is unclear whether justice-based obligations will influence host attitudes toward climate migrants. Using an online survey of 238 Aotearoa New Zealanders, we explore how beliefs about anthropogenic climate change, climate justice and global responsibility contribute to public attitudes towards climate migrants. Overall, people thought more positively of immigrants in general than of climate migrants. Through moderated mediation analyses, we observed that people with stronger belief in anthropogenic climate change were more positive towards climate migrants. This pattern was related to people’s beliefs about climate justice and justice-based migration approaches. Findings suggest that host perceptions of climate migrants are connected to being aware of the ties between greenhouse gas emissions and migration. We outline anticipated challenges and potential opportunities for both migrant communities and the nations in which they seek refuge.
Circulating tumor DNA predicts outcome in metastatic gastroesophageal cancer
Authors: van Velzen Merel J. M. , Creemers Aafke , van den Ende Tom , Schokker Sandor , Krausz Sarah , Reinten Roy J. , Dijk Frederike , van Noesel Carel J. M. , Halfwerk Hans , Meijer Sybren L. , Mearadji Banafsche , Derks Sarah , Bijlsma Maarten F. , van Laarhoven Hanneke W. M. 
Published: June 2022

Abstract
Background
Circulating tumor DNA (ctDNA) has predictive and prognostic value in localized and metastatic cancer. This study analyzed the prognostic value of baseline and on-treatment ctDNA in metastatic gastroesophageal cancer (mGEC) using a region-specific next generation sequencing (NGS) panel.

Methods
Cell free DNA was isolated from plasma of patients before start of first-line palliative systemic treatment and after 9 and 18 weeks. Two NGS panels were designed comprising the most frequently mutated genes and targetable mutations in GEC. Tumor-derived mutations in matched metastatic biopsies were used to validate that the sequencing panels assessed true tumor-derived variants. Tumor volumes were calculated from baseline CT scans and correlated to variant allele frequency (VAF). Survival analyses were performed using univariable and multivariable Cox-regression analyses.

Results
ctDNA was detected in pretreatment plasma in 75% of 72 patients and correlated well with mutations in metastatic biopsies (86% accordance). The VAF correlated with baseline tumor volume (Pearson’s R 0.53, p < 0.0001). Detection of multiple gene mutations at baseline in plasma was associated with worse overall survival (OS, HR 2.16, 95% CI 1.10–4.28; p = 0.027) and progression free survival (PFS, HR 2.71, 95% CI 1.28–5.73; p = 0.009). OS and PFS were inferior in patients with residual detectable ctDNA after 9 weeks of treatment (OS: HR 4.95, 95% CI 1.53–16.04; p = 0.008; PFS: HR 4.08, 95% CI 1.31–12.75; p = 0.016).

Conclusion
Based on our NGS panel, the number of ctDNA mutations before start of first-line chemotherapy has prognostic value. Moreover, residual ctDNA after three cycles of systemic treatment is associated with inferior survival.
Three Paths to Feeling Just: How Managers Grapple with Justice Conundrums During Organizational Change
Authors: Zwank Julia , Diehl Marjo-Riitta , Fortin Marion 
Published: June 2022

AbstractManagers tasked with organizational change often face irreconcilable demands on how to enact justice—situations we call justice conundrums. Drawing on interviews held with managers before and after a planned large-scale change, we identify specific conundrums and illustrate how managers grapple with these through three prototypical paths. Among our participants, the paths increasingly diverged over time, culminating in distinct career decisions. Based on our findings, we develop an integrative process model that illustrates how managers grapple with justice conundrums. Our contributions are threefold. First, we elucidate three types of justice conundrums that managers may encounter when enacting justice in the context of planned organizational change (the justice intention-action gap, competing justice expectations, and the justice of care vs. managerial-strategic justice) and show how managers handle them differently. Second, drawing on the motivated cognition and moral disengagement literature, we illustrate how cognitive mechanisms coalesce to allow managers to soothe their moral (self-) concerns when grappling with these conundrums. Third, we show how motivated justice intentions ensuing from specific justice motives, moral emotions, and circles of moral regard predict the types of justice conundrums managers face and the paths they take to grapple with them.
Does testosterone mediate the relationship between vitamin D and prostate cancer progression? A systematic review and meta-analysis
Authors: Robles Luke A. , Harrison Sean , Tan Vanessa Y. , Beynon Rhona , McAleenan Alexandra , Higgins Julian PT. , Martin Richard M. , Lewis Sarah J. 
Published: June 2022

Abstract
Purpose
Observational studies and randomized controlled trials (RCTs) have shown an association between vitamin D levels and prostate cancer progression. However, evidence of direct causality is sparse and studies have not examined biological mechanisms, which can provide information on plausibility and strengthen the evidence for causality.

Methods
We used the World Cancer Research Fund International/University of Bristol two-stage framework for mechanistic systematic reviews. In stage one, both text mining of published literature and expert opinion identified testosterone as a plausible biological mechanism. In stage two, we performed a systematic review and meta-analysis to assess the evidence from both human and animal studies examining the effect of vitamin D on testosterone, and testosterone on advanced prostate cancer (diagnostic Gleason score of ≥ 8, development of metastasis) or prostate cancer-specific mortality.

Results
A meta-analysis of ten human RCTs showed evidence of an effect of vitamin D on total testosterone (standardised mean difference (SMD) = 0.133, 95% CI =  − 0.003–0.269, I2 = 0.0%, p = 0.056). Five human RCTs showed evidence of an effect of vitamin D on free testosterone (SMD = 0.173, 95% CI =  − 0.104–0.450, I2 = 52.4%, p = 0.220). Three human cohort studies of testosterone on advanced prostate cancer or prostate cancer-specific mortality provided inconsistent results. In one study, higher levels of calculated free testosterone were positively associated with advanced prostate cancer or prostate cancer-specific mortality. In contrast, higher levels of dihydrotestosterone were associated with lowering prostate cancer-specific mortality in another study. No animal studies met the study eligibility criteria.

Conclusion
There is some evidence that vitamin D increases levels of total and free testosterone, although the effect of testosterone levels within the normal range on prostate cancer progression is unclear. The role of testosterone as a mechanism between vitamin D and prostate cancer progression remains inconclusive.
Comparing the Clinical Outcomes Observed with Rivaroxaban Versus Warfarin for the Management of Obese Patients with Non-valvular Atrial Fibrillation: a Systematic Review and Meta-analysis
Authors: Zhuo Xiaojun , Wang Jian , Shao Lihui 
Published: June 2022

Abstract
Background
Atrial fibrillation (AF) is an irregular heart rhythm which is becoming more and more common in this new era. Obesity is a risk factor for cardiovascular events, and obese patients are more at risk for stroke. The Framingham Heart Study demonstrated an increase in the developmental risk of AF by 4% for every unit (kg/m2) increase in body mass index (BMI). An anticoagulant is often required for the management of such patients. In this analysis, we aimed to systematically compare the clinical outcomes which were associated with rivaroxaban versus warfarin for the treatment of obese patients with non-valvular AF.

Methods
PubMed, EMBASE, Web of Science, http://www.ClinicalTrials.gov, Google Scholar, and Cochrane Central were the searched databases. Clinical outcomes including stroke, systemic embolism, and major bleeding were the endpoints. In this study, dichotomous data were analyzed by the RevMan software version 5.4. Risk ratio (RR) with 95% confidence interval (CI) was used for result interpretation.

Results
Ten studies consisting of a total number of 168,081 obese participants were included whereby 81,332 participants were treated with rivaroxaban and 86,749 participants were treated with warfarin. The risks of ischemic (RR: 0.79, 95% CI: 0.74–0.84; P = 0.00001) and hemorrhagic stroke (RR: 0.61, 95% CI: 0.48–0.76; P = 0.0001) as well as systemic embolism (RR: 0.73, 95% CI: 0.62–0.87; P = 0.0004) were significantly lower with rivaroxaban compared to warfarin for the management of these obese patients with non-valvular AF. Rivaroxaban was also associated with a significantly lower risk of major bleeding (RR: 0.75, 95% CI: 0.65–0.87; P = 0.0001).

Conclusion
Based on this analysis, rivaroxaban seemed to be a better option in comparison to warfarin, due to its association with significantly lower risks of stroke and bleeding outcomes in obese patients with non-valvular AF. However, this hypothesis should further be confirmed in larger clinical trials.
Evaluation of proposed genetic goals and targets for the Convention on Biological Diversity
Authors: Frankham Richard 
Published: June 2022

AbstractIn the current negotiations regarding revision of the Convention on Biological Diversity (CBD) proposals have been made to strengthen the genetic goals, indicators, and targets for wild species in natural habitats by specifying “tolerable” losses of genetic diversity. However, they have not been subjected to evaluations of their continued use over 100 years, a common conservation time frame. I evaluated six scenarios (3, 5 or 10% loss of genetic diversity [heterozygosity] over 8 or 32 years) proposed as targets for revision of genetic indicators in CBD by predicting their consequences on genetic diversity, inbreeding, fitness, and evolutionary potential when applied at the same rate for 100 years. All proposals lead to substantial genetic harm to species when continued for 100 years that will compromise species persistence, especially in the context of environmental change. Consequently, none of the proposals are suitable for inclusion in the CBD. However, alternative indicators are proposed that would reflect improvements in the genetic status of populations and species, namely (1) the number of species and their populations being maintained at sizes sufficient to retain evolutionary potential in perpetuity, and (2) the number of species for which population genetic connectivity has been improved.
On the lifetimes of two-dimensional droplets on smooth wetting patterns
Authors: Haynes Matthew , Pradas Marc 
Published: June 2022

AbstractWe study the evolution and lifetime of droplets evaporating on a smooth chemical pattern, which is characterised by a spatially varying contact angle. We formulate a model that combines the evaporation rate of the droplet for a given volume with the static stability of the droplet as the volume changes in time quasi-statically. We derive an exact equation for the evaporation rate that is studied analytically under the limiting cases of nearly neutral wetting and highly hydrophilic conditions. We find that the evaporation rate of the droplet is highly dependent on the size and shape of the fictitious infinity where a far-field boundary conditions needs to be applied. We also study how the droplet’s lifetime depends on the averaged contact angle and strength $$\varepsilon $$
ε
of the chemical pattern, observing that the lifetime of the droplet is maximised for a droplet with average contact angle $$\pi /2$$

π
/
2

and with $$\varepsilon \lesssim 0.1$$

ε
≲
0.1

.
The “Gift” of Time: Documenting Faculty Decisions to Stop the Tenure Clock During a Pandemic
Authors: Smith Jessi L. , Vidler L. Lynn , Moses Michele S. 
Published: June 2022

AbstractAnticipating the deleterious effects of pandemic mitigation protocols on faculty’s research and creative work, many universities introduced mechanisms for pre-tenured faculty to receive tenure clock extensions. Unlike most stop-the-clock extensions, which occur on an individual basis, the stop-the-tenure-clock during COVID-19 was a mass-triggering event that applied to all faculty. Informed by social role theory, we examined this unique situation of stop-the-tenure clock decisions by faculty at two different universities within the same state system. Institutional level demographic and field of study data on faculty decision making at one high research activity university (n = 97) and one very high research activity university (n = 387) were examined at two time points; a first tenure-clock stop opportunity and a second tenure-clock stop opportunity. Results show that although the overall rates of clock-stops were much larger at the research-intense university, the characteristics of who was most likely to accept or opt out of the first tenure-clock stop were similar at both universities. Ethnic minoritized faculty at both universities had greater odds of accepting the clock-stop. Results also showed that at both universities, women were somewhat more likely to accept the first tenure clock extension, and exploratory follow-up shows this gendered decision manifested differently depending on field of study. Relatively few faculty accepted the second tenure clock-stop. Our findings provide a portrait of who accepts or declines tenure clock extensions with important implications for downstream effects on equity within the academy.
Trust in Artificial Intelligence: Comparing Trust Processes Between Human and Automated Trustees in Light of Unfair Bias
Authors: Langer Markus , König Cornelius J. , Back Caroline , Hemsing Victoria 
Published: June 2022

AbstractAutomated systems based on artificial intelligence (AI) increasingly support decisions with ethical implications where decision makers need to trust these systems. However, insights regarding trust in automated systems predominantly stem from contexts where the main driver of trust is that systems produce accurate outputs (e.g., alarm systems for monitoring tasks). It remains unclear whether what we know about trust in automated systems translates to application contexts where ethical considerations (e.g., fairness) are crucial in trust development. In personnel selection, as a sample context where ethical considerations are important, we investigate trust processes in light of a trust violation relating to unfair bias and a trust repair intervention. Specifically, participants evaluated preselection outcomes (i.e., sets of preselected applicants) by either a human or an automated system across twelve selection tasks. We additionally varied information regarding imperfection of the human and automated system. In task rounds five through eight, the preselected applicants were predominantly male, thus constituting a trust violation due to potential unfair bias. Before task round nine, participants received an excuse for the biased preselection (i.e., a trust repair intervention). The results of the online study showed that participants have initially less trust in automated systems. Furthermore, the trust violation and the trust repair intervention had weaker effects for the automated system. Those effects were partly stronger when highlighting system imperfection. We conclude that insights from classical areas of automation only partially translate to the many emerging application contexts of such systems where ethical considerations are central to trust processes.