bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravity field forward modelling using tesseroids accelerated by Taylor series expansion and symmetry relations
Authors: Zeng Xianghang , Wan Xiaoyun , Lin Miao , Wang Wenbin 
Published: April 2022

SUMMARY
In this study, we developed a new method that can significantly accelerate the forward modelling of gravity fields generated by large-scale tesseroids while keeping the computational accuracy as high as possible. The cost of the high efficiency is that the method only works under the assumptions that (1) all tesseroids in the same latitude band have the same horizontal dimension, (2) the computation points are located at the same surface level and aligned with the horizontal centres of tesseroids and (3) each tesseroid has a constant or linearly varying density. The new method first integrates the kernel function of the Newton’s volume integral analytically in the radial direction to eliminate its dependence on the vertical dimension of the tesseroid, and then expands the integrated kernel function into a Taylor series up to a certain order. Because the Taylor series expansion term of the integrated kernel function is an odd or even function of the difference between the longitudes of the tesseroid and computation point, there exist shifting or swapping symmetry relations among the gravity field of tesseroids. Consequently, the shifting or swapping symmetry is extended to the tesseroids with unequal vertical dimensions. Numerical experiments using the spherical shell model are conducted to verify the effectiveness of the new method. The results show that the computational speed of the new method is about 30 times faster than that of the traditional method, which employs the Gauss–Legendre quadrature rule and a 2-D adaptive subdivision approach, while keeping almost the same computational accuracy. When applying the new method to an ice shell with unequal thicknesses, the results reveal that the relative errors of calculating V, Vz and Vzz are smaller than 10−8, 10−6 and 10−4, respectively if the Taylor series expansion is truncated at order 4, while the computational time consumed by the new method is about 7 times less than that of the traditional method. Finally, the influence of the truncation order on the computational accuracy and the strategies for dividing the latitude band into several parts to further improve the accuracy are discussed.
Molecular connections between circadian clock and health/ageing
Authors: Nakahata Yasukazu , Fukada Yoshitaka 
Published: April 2022

Abstract
For decades, considerable efforts have been expended for solving the molecular mechanisms of disease progression. An important clue to tackle this question is the circadian clock. Recent findings have uncovered previously unknown molecular connections between circadian clock and disease incidence, consequently causing the ageing process. Furthermore, ‘chronotherapy’ is emerging as a new concept of optimizing the time of the day for drug administration according to target gene expressions in order to maximize therapeutic efficacy and minimize the side effects. This concept will help cure patients and prevent them from suffering evitable pain and side effects. This JB special issue ‘Molecular connections between circadian clock and health/aging’ discusses how the circadian clocks link to health and ageing from molecular to organismal levels.
The quantitative characterization of hydraulic fracture connectivity from a postmortem investigation
Authors: Jayawickrama Eranga G , Muto Jun , Sasaki Osamu , Nagahama Hiroyuki 
Published: April 2022

AbstractTwo bio-siliceous Onnagawa (ONG I and ONG II) shale samples have been hydraulically fractured under two constant differential stresses (60 and 85 MPa, respectively) to investigate the fracture network's connectivity evolution by a postmortem analysis. The pressure inside the drilled borehole in a cylindrical core sample is increased above the confining pressure (10 MPa) until failure by hydraulic fracture. The two samples failed at two different borehole pressures (ONG I: 42 MPa, ONG II: 16 MPa). Fractured samples were scanned in an industrial X-ray CT machine and the tomographic images of the fracture network were extracted for a postmortem investigation. From the fracture volume segments, obtained by thresholding the frequency distribution of the fracture network's voxel values, a quantitative estimation of fracture connectivity was carried out. The connectivity was quantified based on the relative entropy of size distribution of fractures (${H_r}$), a method adapted from information theory. Fracture connectivity estimation shows that ${H_r}$ is at a maximum value when the fractures show a significant distribution with very limited connectivity. The value of ${H_r}$ is at a minimum and close to 0 when a well-linked fracture network is formed. In both samples, this minimum was attained at the threshold of 43k indicating the highest connectivity and the best representation of the fracture network. The extracted fracture network of ONG I showed a multi-winged hydraulic fracture network while a planar conventional two-winged hydraulic fracture network had been generated in ONG II with a lower fracture volume.
Development and Psychometric Testing of the Academic Clinical Nurse Educator Skill Acquisition Tool
Authors: Shellenbarger Teresa , Sebach Aaron M. 
Published: April 2022

Abstract

AIM
This article reports the development and psychometric testing of an instrument to measure academic clinical nurse educator skill acquisition.

BACKGROUND
Little research explores clinical nurse educator competence.

METHOD
Using the National League for Nursing Academic Clinical Nurse Educator core competencies and a literature review, newly created clinical nurse educator skill acquisition items underwent two rounds of content validity testing. The resulting 40-item Academic Clinical Nurse Educator Skill Acquisition Tool was pilot tested with a convenience sample of 133 clinical nurse educators.

RESULTS
The Academic Clinical Nurse Educator Skill Acquisition Tool demonstrated adequate validity and internal consistency reliability. Factor analysis identified two factors: facilitating clinical learning through the use of effective teaching, assessment, and evaluation and promoting nursing enculturation.

CONCLUSION
Further use of this tool may provide insight about the psychometrics, offer information about clinical teaching competence, and could lead to improved orientation and mentoring programs for clinical nurse educators.
Connectome Analysis in an Individual with SETD1B-Related Neurodevelopmental Disorder and Epilepsy
Authors: Weng Rosa , Nenning Karl-Heinz , Schwarz Michelle , Riedhammer Korbinian M. , Brunet Theresa , Wagner Matias , Kasprian Gregor , Lehrner Johann , Zimprich Fritz , Bonelli Silvia B. , Krenn Martin 
Published: April 2022

ABSTRACT:

Objective:
Causative variants in SETD1B, encoding a lysine-specific methyltransferase, have recently been associated with a neurodevelopmental phenotype encompassing intellectual disability, autistic features, pronounced language delay, and epilepsy. It has been noted that long-term and deep phenotype data are needed to further delineate this rare condition.

Methods:
In this study, we provide an in-depth clinical characterization with long-term follow-up and trio exome sequencing findings to describe one additional individual affected by SETD1B-related disorder. The diagnostic workup was complemented by a functional magnetic resonance imaging (fMRI) study.

Results:
We report a 24-year-old male individual with an early-onset neurodevelopmental disorder with epilepsy due to the de novo missense variant c.5699A>G, p.(Tyr1900Cys) in SETD1B (NM_015048.1). He exhibited delayed speech development, autism spectrum disorder, and early-onset epilepsy with absence and generalized tonic-clonic seizures. Despite profoundly impaired communication skills, ongoing improvements regarding language production have been noted in adulthood. fMRI findings demonstrate abnormal language activation and resting-state connectivity structure.

Conclusion:
Our report expands the previously delineated phenotype of SETD1B-related disorder and provides novel insights into underlying disease mechanisms.
Rare Cutaneous Malignancies in Skin of Color
Authors: Mosallaei Daniel , Lee Erica B. , Lobl Marissa , Clarey Dillon , Wysong Ashley 
Published: April 2022

BACKGROUND
There is a scarcity of information regarding the clinical characteristics of rare cutaneous malignancies in skin of color that has yet to be comprehensively explored.

OBJECTIVE
To review and compile the racial differences in epidemiology, clinical presentation, histology, treatments, and outcomes of 3 rare skin cancers: dermatofibrosarcoma protuberans (DFSP), Merkel cell carcinoma (MCC), and sebaceous carcinoma (SC).

METHODS
Several searches with keywords denoting specific skin cancer type and race were conducted on PubMed to complete this narrative review.

RESULTS
We analyzed 50 sources that were relevant to the initial objective.

CONCLUSION
The literature demonstrates that there are nuances in DFSP, MCC, and SC unique to African Americans, Asians/Pacific Islanders, and Hispanics that may differ significantly from Caucasian counterparts. African Americans consistently suffer from the worst clinical outcomes in all 3 rare cutaneous malignancies reviewed. Greater physician awareness and knowledge of the discussed racial differences is the preliminary step to address these disparities.
Towards Precision Dosing of Clozapine in Schizophrenia: External Evaluation of Population Pharmacokinetic Models and Bayesian Forecasting
Authors: Lereclus Aurélie , Korchia Théo , Riff Camille , Dayan Frédéric , Blin Olivier , Benito Sylvain , Guilhaumou Romain 
Published: April 2022

Background:
Therapeutic drug monitoring and treatment optimization of clozapine are recommended, owing to its narrow therapeutic range and pharmacokinetic (PK) variability. This study aims to assess the clinical applicability of published population PK models by testing their predictive performance in an external data set and to determine the effectiveness of Bayesian forecasting (BF) for clozapine treatment optimization.

Methods:
Available models of clozapine were identified, and their predictive performance was determined using an external data set (53 patients, 151 samples). The median prediction error (PE) and median absolute PE were used to assess bias and inaccuracy. The potential factors influencing model predictability were also investigated. The final concentration was reestimated for all patients using covariates or previously observed concentrations.

Results:
The 7 included models presented limited predictive performance. Only 1 model met the acceptability criteria (median PE ≤ ±20% and median absolute PE ≤30%). There was no difference between the data used for building the models (therapeutic drug monitoring or PK study) or the number of compartments in the models. A tendency for higher inaccuracy at low concentrations during treatment initiation was observed. Heterogeneities were observed in the predictive performances between the subpopulations, especially in terms of smoking status and sex. For the models included, BF significantly improved their predictive performance.

Conclusions:
Our study showed that upon external evaluation, clozapine models provide limited predictive performance, especially in subpopulations such as nonsmokers. From the perspective of model-informed prediction dosing, model predictability should be improved using updating or metamodeling methods. Moreover, BF substantially improved model predictability and could be used for clozapine treatment optimization.
Efficacy evaluation of Chinese herbal medicine, VGH-BPH1, for patients with benign prostatic hyperplasia: A randomized, double-blind, placebo-controlled, and crossover study
Authors: Tran Diem Ngoc Hong , Yeh Hsin-Fu , Huang William J. , Wu Pei-Wen , Liao Ying-Ju , Hwang Shinn-Jang , Kung Yen-Ying , Yang Jen-Lin , Wu Ta-Peng , Hsu Chung-Hua , Chen Fang-Pey 
Published: April 2022

Background:
Benign prostatic hyperplasia (BPH) can affect quality of life and cause various complications. Previous studies have suggested that Chinese herbal medicine can alleviate symptoms in patients with BPH. This study aimed to investigate whether the Chinese herbal medicine prescription VGH-BPH1 can alleviate BPH symptoms when used as an add-on treatment.

Methods:
In this crossover, randomized, double-blind, placebo-controlled trial, patients with BPH were randomly segregated into two groups: group A received VGH-BPH1, and group B received a placebo for 8 weeks. Subsequently, after a 2-week wash-out period, the two groups were switched to the opposite treatment for another 8 weeks. The International Prostate Symptoms Score and Aging Male Symptoms Score were adopted as the primary outcomes to assess improvement in BPH and patient quality of life. The secondary outcomes were the International Index of Erectile Function, Constitution Chinese Medicine Questionnaire, uroflowmetry results, and postvoid residual urine volume.

Results:
VGH-BPH1 treatment significantly decreased the International Prostate Symptoms Score total score (p = 0.027); however, no significant difference was observed between the treatment and placebo groups. The Aging Male Symptoms Score “joint pain and muscular ache” score in the VGH-BPH1 group was significantly lower than that of the placebo group (p = 0.022). The “physical exhaustion” score also exhibited a decreasing trend when both groups were compared (p = 0.057).

Conclusion:
Although VGH-BPH1 treatment did not outperform the placebo in terms of improving BPH symptoms, it resulted in improvement in several quality of life indicators when relative to the placebo. Future research using a larger sample size with appropriate amendments to the protocol should be conducted to further investigate the effects of VGH-BPH1.
Morphometric and ultrasonographic determinants of difficult laryngoscopy in obese patients: A prospective observational study
Authors: Wu Yu-Ming , Su Yen-Hao , Huang Shih-Yu , Wang Chien-Wun , Shen Shih-Chiang , Chen Jui-Tai , Lo Po-Han , Cherng Yih-Giun , Wu Hsiang-Ling , Tai Ying-Hsuan 
Published: April 2022

Background:
Obese people have a higher risk of difficult laryngoscopy due to their thick neck, large tongue, and redundant pharyngeal soft tissue. However, there is still no established predictive factor for difficult laryngoscopy in obese population.

Methods:
We conducted a prospective assessor-blind observational study to enroll adult patients with a body mass index of 30 kg·m-2 or higher undergoing laparoscopic sleeve gastrectomy at a medical center between May 2020 and August 2021. Conventional morphometric characteristics along with ultrasonographic airway parameters were evaluated before surgery. The primary outcome was difficult laryngoscopy, defined as a Cormack and Lehane’s grade III or IV during direct laryngoscopy. Logistic regression analyses were performed to evaluate the association between included factors and difficult laryngoscopy. Discrimination performance of predictive factors was assessed using area under the receiver operating characteristic curve (AUC).

Results:
A total of 80 patients were evaluated, and 17 (21.3%) developed an event of difficult laryngoscopy. Univariate analyses identified five factors associated with difficult laryngoscopy, including age, sex, hypertension, neck circumference, and cross-sectional area of tongue base. After adjusting for these variables, neck circumference was the only independent influential factor, adjusted odds ratio: 1.227 (95% confidence interval, 1.009–1.491). Based on Youden’s index, the optimal cutoff of neck circumference was 49.1 cm with AUC: 0.739 (sensitivity: 0.588, specificity: 0.889; absolute risk difference: 0.477, and number needed to treat: 3).

Conclusion:
Greater neck circumference was an independent risk factor for difficult laryngoscopy in obese patients. This finding provides a way of reducing unanticipated difficult airway in this high-risk population.
Impact of Stroke Survivors' Physical Disability on the Presence of Caregiver Burden: A Systematic Review
Authors: Shamoun Charles , Harris Margaret A. 
Published: April 2022

ABSTRACT

BACKGROUND: Caregiver burden associated with caring for stroke survivors remains a prominent issue in nursing. With stroke being a leading cause of disability worldwide, it is essential that the impact of the stroke survivor's physical disability be analyzed so interventions can be developed to relieve related caregiver burden. The purpose of this systematic review is to review the existing nursing and allied-health literature aimed at the impact of stroke survivors' physical disability on the presence of caregiver burden. METHODS: A systematic review of the CINAHL® and PubMed databases was conducted using Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (searched on June 16, 2021). Study inclusion criteria for this review were as follows: (1) publication in the last 5 years, (2) examined the impact of stroke survivors' physical disability on caregiver burden, (3) caregiver-survivor dyads 18 years or older, (4) published in English, and (5) longitudinal study designs (an exception for reports that present findings not demonstrated in longitudinal studies). Data extracted from articles included sample characteristics, study design, instruments, analyses, and results. RESULTS: A total of 7 studies met the inclusion criteria and were synthesized for use in this systematic review. These studies implemented a variety of instruments to assess for both physical disability in the stroke patient and caregiver burden. A positive correlation between physical disability and caregiver burden was universally reported. CONCLUSION: Further nursing research is warranted to explore the aspects of physical disability that contribute to caregiver burden and to develop interventions to improve the physical functioning of stroke survivors, include social determinants of health, and specifically address the greatest contributors to caregiver burden.
Total Lesion Glycolysis on 18F-FDG PET/CT Is a Better Prognostic Factor Than Tumor Dose on 90Y PET/CT in Patients With Hepatocellular Carcinoma Treated With 90Y Transarterial Radioembolization
Authors: Hwang Sang Hyun , Hong Hye-Suk , Kim Dongwoo , Kim Gyoung Min , Lee Hye Won , Lee Misu , Kim Do Young , Park Mi-Ae , Yun Mijin 
Published: April 2022

Purpose
This study aimed to evaluate the prognostic value of metabolic parameters on 18F-FDG PET/CT and tumor dose (TD) on posttreatment 90Y PET/CT in patients with hepatocellular carcinoma (HCC) who underwent 90Y transarterial radioembolization (TARE).

Patients and Methods
Forty-seven HCC patients treated with 90Y TARE were retrospectively enrolled between January 2013 and October 2018. 18F-FDG PET/CT was performed before treatment. Maximum tumor SUV–to–mean normal liver SUV ratio (TLR), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured for each patient. Voxel dosimetry was performed on 90Y PET/CT images to measure TD. The prognostic significance of metabolic parameters on 18F-FDG PET/CT, TD on 90Y PET/CT, and clinical factors for overall survival (OS) was evaluated. In addition, TD on 90Y PET/CT was analyzed in relation to the administered dose of 90Y-labeled microspheres and metabolic parameters on 18F-FDG PET/CT.

Results
The median patient age was 57 years, and 37 patients (78.7%) were men. During the follow-up period, 25 patients (53.2%) died. In univariable analysis, Barcelona Clinic Liver Cancer stage C, Child-Pugh score, TD on 90Y PET/CT, TLR, MTV, and TLG were significant prognostic factors affecting OS (P < 0.05). In multivariable analysis, Barcelona Clinic Liver Cancer stage C and high TLG on 18F-FDG PET/CT were independent prognostic factors for OS (P < 0.05). The 1-year OS rates were 72.9% in patients with low TLG and 33.3% in patients with high TLG (P < 0.05). We also found that TD on 90Y PET/CT was not correlated with the administered dose of 90Y-labeled microspheres, but negatively correlated with TLG on pretreatment 18F-FDG PET/CT (P < 0.05).

Conclusions
TLG, a parameter incorporating both the degree of 18F-FDG uptake and amount of metabolically active tumor volume on pretreatment 18F-FDG PET/CT, is a better prognostic factor than TD on 90Y PET/CT for predicting OS in HCC patients treated with 90Y TARE.
Peritoneal Tuberculosis Mimicking Peritoneal Carcinomatosis on 68Ga-FAPI-04 and 18F-FDG PET/CT
Authors: Alçın Göksel , Tatar Gamze , Şahin Rahime , Baloğlu Mehmet Can , Çermik Tevfik Fikret 
Published: April 2022

Abstract
We report a case of tuberculosis peritonitis in a 26-year-old woman who presented with abdominal pain, fatigue, and weight loss for the last 4 months. Abdominal US and CT demonstrated intra-abdominal massive ascites, misty mesentery, and diffuse peritoneal thickening. In addition, 3 nodular lesions were detected in the right lung. 18F-FDG PET/CT showed hypermetabolism in lung nodules, mesenteric area, peritoneal thickening, and ascites. 68Ga-FAPI-04 (fibroblast activation protein–specific inhibitor) PET/CT imaging was also performed; high uptakes were detected in the same regions of 18F-FDG PET/CT. Tuberculosis diagnosis was made after histopathological examination of wedge resection of the right lung.
Crowdlending for renewable energy projects: key factors to improve performance
Authors: Vásquez-Ordóñez Luis René , Lassala Carlos , Ulrich Klaus , Ribeiro-Navarrete Samuel 
Published: April 2022

PurposeThe importance of crowdfunding has grown considerably in recent years. Its potential as a source of financing has captured the attention of academia. In view of the challenge of creating a cleaner energy system and the considerable investments required to reach this goal, the literature has pointed to crowdlending as a viable alternative due to its social qualities. However, the literature on this regard is still scarce. This paper aims to contribute to this gap by examining some of the critical factors that determine the performance of financing renewable energy projects through crowdlending.Design/methodology/approachThe data collected from the ECrowd! platform is studied through fuzzy-set qualitative comparative analysis (fsQCA) as research method.FindingsThe results emphasize the importance of the founders’ presence in social networks and the amount of information provided in the description. They also suggest that investors do not react negatively to projects of larger amounts and terms and that giving rewards does not have a significant impact on the campaigns results.Originality/valueThe literature linking crowdfunding and sustainability is still scarce, which is why this paper contributes to filling this gap by identifying some of the factors that have a significant impact on the performance of campaigns. Critical conditions used are grouped into three categories: loan characteristics, project description and social capital. Conclusions help promoters and platforms to know what actions they should take in order to enhance their campaigns performance.