bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Immunogenicity of a Third Dose of SARS-CoV-2 mRNA Vaccine — An Interim Analysis
Authors: Anderson Evan , Jackson Lisa , Rouphael Nadine , Widge Alicia , Montefiori David , Doria-Rose Nicole , Suthar Mehul , Cohen Kristen , O'Connell Sarah , Makowski Mat , Makhene Mamodikoe , Buchanan Wendy , Spearman Paul , Creech C. Buddy , O'Dell Sijy , Schmidt Stephen , Leav Brett , Bennett Hamilton , Pajon Rolando , Posavad Christine , Hural John , Beigel John , Albert Jim , Abebe Kuleni , Eaton Amanda , Rostad Christina , Rebolledo Paulina , Kamidani Satoshi , Graciaa Daniel , Coler Rhea , McDermott Adrian , Ledgerwood Julie , Mascola John , DeRosa Stephen , Neuzil Kathleen , McElrath M. Juliana , Roberts Paul 
Published: May 2022

Abstract
Waning immunity after two SARS-CoV-2 mRNA vaccinations and the emergence of variants precipitated the need for a third dose of vaccine. We evaluated early safety and immunogenicity after a third mRNA vaccination in adults who received the mRNA-1273 primary series in the Phase 1 trial approximately 9 to 10 months earlier. The booster vaccine formulations included 100 mcg of mRNA-1273, 50 mcg of mRNA-1273.351 that encodes Beta variant spike protein, and bivalent vaccine of 25 mcg each of mRNA-1273 and mRNA-1273.351. A third dose of mRNA vaccine appeared safe with acceptable reactogenicity. Vaccination induced rapid increases in binding and neutralizing antibody titers to D614G, Beta, and Delta variants that were similar or greater than peak responses after the second dose. Spike-specific CD4+ and CD8+ T cells increased to similar levels as after the second dose. A third mRNA vaccination was well tolerated and generated robust humoral and T cell responses. ClinicalTrials.gov numbers NCT04283461 (mRNA-1273 Phase 1) and NCT04785144 (mRNA-1273.351 Phase 1)
What position does Spain occupy in the EU-28 (2008-2017) from the standpoint of natural and managerial efficiency?
Authors: Yñiguez Rocio , Sanz-Diaz Maria Teresa , ortega-Irizo Francisco Javier , Velasco-Morente Francisco 
Published: May 2022

Abstract
The European Union (EU) has become the group of countries most interested in the fight against climate change and is therefore committed to reducing greenhouse gas emissions. This research analyses the Natural and Managerial efficiency of the EU-28 countries for the period 2008–2017. The Data Envelopment Analysis methodology is used and Natural and Managerial Malmquist indices are obtained by assuming that a shift in the efficiency frontier exists and by considering that frontier crossings are possible across the different periods considered. The input variables used are those of Gross Fixed Capital Formation (GFCF), non-emitting energy consumption, and employment. Gross domestic product (GDP) and greenhouse gas (GHG) emissions are taken as the desirable and undesirable output variables, respectively. The results of the analysis indicate that both Natural and Managerial efficiency have worsened in Spain during the period considered, whereby Spain has dropped in the relevant ranking. With regard to the Malmquist Index (MI), during this entire period, the position of the evolution of Spain in relation to all EU countries was better within the sphere of Managerial efficiency, than in that of Natural efficiency.
Effects of bread fortification with pomegranate peel powder on health status: Study design and protocol
Authors: Zare Maryam , Goli Amir Hossein , Karimifar Mozhgan , Tarrahi Mohammad Javad , Rezaei Atefe , Amani Reza 
Published: May 2022

Abstract
Introduction: The oxidative stress caused by the creation and breakdown of reactive oxygen species affects glucose tolerance, B-cell function, insulin resistance, and metabolites containing free fatty acids. Therefore, owing to their health benefits and ability to prevent oxidative stress, functional foods have received particular attention. This research aims to assess strategies used to ameliorate oxidative stress and inflammation in patients with type 2 diabetes (T2DM). Methods and Analysis: A randomized controlled trial will be conducted on 90 patients with T2DM. Run-in courses will last for two weeks. The intervention and control groups will receive wheat bread with and without pomegranate peel powder, respectively. Several variables, including anthropometric data, fasting plasma glucose, hemoglobin A1C, lipid profile, insulin level, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and mood state, will be measured at baseline and after three months of the intervention. Beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) will also be assessed. Research findings will increase the scientific knowledge about the use of bread in health intervention targeting.Ethics and dissemination: The protocol has been approved by the Ethics committee of the faculty of Medicine of the University of Isfahan (IR.MUI.RESEARCH.REC.1399.087). The study results will be disseminated through peer-reviewed publications and presentations at scientific meetings.Trial Registration: Registered in the Iranian Registry of Clinical Trials (ID: IRCT2019209045672N1) on September 21, 2020.
Predictors of Colonoscopy Use Among Asian Indians in New York City, 2003-2016
Authors: Nagpal Neha , Xia Yuhe , Lin Kevin , Glenn Matthew , Ng Sandy , Trinh-Shevrin Chau , Troxel Andrea B. , Kwon Simona C. , Liang Peter S. 
Published: May 2022

Abstract
Background: Indians are among the most under-screened Asian American subgroups, but there is limited data for this population. Methods: Using 2003-2016 the New York City Community Health Survey, we examined the association between sociodemographic and medical factors and up-to-date colonoscopy (defined as colonoscopy within the last 10 years) in Asian Indians using logistic regression over four time periods: 2003-2008, 2009-2012, 2013-2014, 2015-2016. Results: On multivariable analysis, only language was associated with colonoscopy uptake in more than one time period. Compared to participants who preferred English, those who preferred an “Other” language were less likely to be up-to-date on colonoscopy in 2003-2008 (OR 0.15, 95% CI 0.04-0.66), while those who preferred an Indian language were less likely to have been up-to-date in 2013-2014 (OR 0.12, 95% CI 0.02-0.66). Conclusions: Among Asian Indians living in New York City, language appeared to be an important predictor of colonoscopy use and colorectal cancer screening.
Production of the Final Score Tables of the Soccer Tournaments using Functional Programming
Authors: Milani Muhammed 
Published: May 2022

Abstract
In sports tournaments, several teams compete with each other, and in the end, it will rank according to the final table of competitions. The results from the tournament will form the final tables. Because each match can obtain different results, a tournament can achieve different final tables. This article presents a systematic method for generating all possible scenarios for the final tables that a football tournament can achieve. In this research, we have only used the teams' results to produce the final tables, and other issues such as the number of goals scored or the goal difference have not been addressed. The proposed recursive method is suitable for functional programming and implemented using Haskell programming Language.
Optimal Configuration of Array Elements for Hybrid Distributed PA-MIMO Radar System Based on Target Detection
Authors: Qi Cheng , Xie Junwei , Zhang Haowei , Ding Zihang , Li Zhengjie 
Published: May 2022

Abstract
How to utilize limited system resources budget to maximize the effectiveness potential of the entire system through optimal allocation has always been a hot issue in radar resource management. This paper establishes a hybrid distributed phased array multiple-input and multiple-output (PA-MIMO) radar system model. It combines coherent processing gain and spatial diversity gain to synergistically improve the target detection performance of the radar system. For the hybrid distributed PA-MIMO radar system, we derive a likelihood ratio (LRT) detector based on the Neyman-Pearson (NP) criterion. The coherent processing gain and spatial diversity gain are jointly optimized by implementing subarray-level and array element-level optimal configuration at both transceiver and transmitter ends. Moreover, a quantum particle swarm optimization-based stochastic rounding (SR-QPSO) solution algorithm is proposed for the integer planning-based configuration model. And the optimal array element configuration strategy is guaranteed to be obtained with fewer iterations and realize the joint optimization between subarray and array levels. Finally, numerical simulations are carried out using three typical optimization problems to demonstrate the effectiveness of the optimal configuration of the hybrid distributed PA-MIMO radar system.
Micro-dissolved fabrication of robust Superhydrophilic and Underwater Superoleophobic membranes based on cotton fabrics for oil/water separation
Authors: Song Jing , Yu Qiuyu , Liang Xinyue , Rao Qin , Wang Peng , Lu Ming , Xiao Hang 
Published: May 2022

Abstract
The superhydrophilic and underwater superoleophobic membranes based on textile possessed excellent separation efficiency and anti-oil fouling property, but the poor stability caused by nanoparticles (NPs) shedding had severely limited the practical application in oily wastewater treatment. In this paper, a feasible method to prepare the robust membranes based on cotton fabric (CF) decorated with TiO 2 NPs and citric acid (CA) using micro-dissolution method was reported. The CF were slightly dissolved in a NaOH/urea solution at low temperature, allowing the incorporation of the TiO 2 NPs into the superficial layers of the fabrics. Then, the vacuum filtration process facilitated the TiO 2 NPs uniformly deposition on the CF surface. In the subsequent coagulation process, the TiO 2 NPs were firmly anchored on the fabric surface. Then, the esterification reaction between CA and cotton was carried out to impart the fabric with superior hydrophilic properties. The prepared membranes were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermogravimetric analysis (TG). Additionally, the separation efficiency and stability of membranes were systematically evaluated. The results of SEM indicated that the TiO 2 NPs were uniformly anchored on the membrane surface. The prepared membranes could not only separate traditional oil/water mixture but also treat complicated oil-in-water (O/W) emulsion with excellent separation efficiency. What’s more, the membranes could withstand various harsh condition and repeated use. Therefore, the prepared TiO 2 /CA decorated membranes have the potential to be used in the practical oily wastewater treatment.
Predictors of indoor particulate matter and carbon monoxide concentrations in households of an informal urban settlement in Fort Portal city, Uganda
Authors: Kansiime Winnifred K. , Mugambe Richard K. , Atusingwize Edwinah , Wafula Solomon T. , Nsereko Vincent , Ssekamatte Tonny , Nalugya Aisha , Coker Eric Stephen , Ssempebwa John C. , Isunju John Bosco 
Published: May 2022

Abstract
Background
Poor indoor air quality (IAQ) is a leading cause of respiratory and cardiopulmonary illnesses. Particulate matter (PM2.5) and carbon monoxide (CO) are critical indicators of IAQ, yet there is limited evidence of their concentrations in urban informal settlements in low-income countries.
Objective
This study assessed household characteristics that predict the concentrations of PM2.5 and CO within households in an informal settlement in Fort Portal City, Uganda.
Methodology:
A cross-sectional study was conducted in 374 households. Concentrations of PM2.5 and CO were measured using Multi-purpose Laser Particle detector and the Carbon Monoxide IAQ Meter respectively. Data on household characteristics were collected using a structured questionnaire and an observational checklist. Data were analysed using STATA version 14.0. Linear regression was used to establish the relationship between PM2.5, CO concentrations and household characteristics.
Results
The majority, 88.8% (332/374) of the households used charcoal for cooking. More than half, 51.9% (194/374) cooked from outdoors. Cooking areas had significantly higher PM2.5 and CO concentrations compared to the living area (t = 18.14, p ≤ 0.05) and (t = 5.77 p ≤ 0.05) respectively. Cooking from outdoors was associated with a 0.112 increase in the PM2.5 concentrations in the cooking area (0.112 [95% CI: -0.069, 1.614; p = 0.033]). Cooking with moderately polluting fuel was associated with a 0.718 increase in CO concentrations (0.718 [95% CI: 0.084, 1.352; p = 0.027]) in the living area.
Discussion
The concentration of PM2.5 and CO during the cooking time for both the cooking area and the living area were above the World Health Organisation Air Quality Guideline of 25µg/m3 and 7ppm for 24 hours respectively. Interventions to improve the indoor air quality in informal settlements should address change in the type of cooking fuels and improvement in the ambient air quality.
Relationship between seminal HIV-1 RNA shedding and genital schistosomiasis in HIV-positive men receiving antiretroviral therapy (ART) along the south shoreline of Lake Malawi: A prospective pilot study.
Authors: Kayuni Sekeleghe A. , Abdullahi Adam , Alharbi Mohammad H. , Makaula Peter , Lampiao Fanuel , Juziwelo Lazarus , LaCourse E. James , Kumwenda Johnstone J. , Leutscher Peter D.C. , Geretti Anna Maria , Stothard J. Russell 
Published: May 2022

Abstract
Background Male Genital Schistosomiasis (MGS) is hypothesized to increase seminal shedding of HIV-1 RNA. We aimed to assess the impact of MGS on genital HIV-1 RNA shedding by longitudinally measuring HIV-1 RNA levels in men established on long-term ART comparing those with and without a diagnosis of MGS. Methods Following optimisation of the GeneXpert® HIV-1 RNA assay for use with seminal fluid, we analysed 76 paired plasma and semen samples collected from 31 men over 12 months, comprising 15 with and 16 subjects without MGS. Study visits occurred at 0, 1, 3, 6 and 12 months. A diagnosis of schistosomiasis was based on Schistosoma positivity using eggs by microscopy of filtrated urine, semen, seminal sediment, POC-CCA test or by testing PCR of seminal sediment or urine at one or more time points. MGS was diagnosed by egg positivity on semen microscopy or PCR of seminal sediment. All subjects were blindly treated with a single dose of praziquantel at each study visit.ResultsAcross the entire study population, HIV-1 RNA was detected in 7/76 (9.2%) seminal samples and 29/76 (38.2%) plasma samples. Among all participants, 5/31 (16.1%) showed HIV-1 RNA detection in one or more seminal samples, with 3/5 (60%) showing HIV-1 RNA detection in semen only with levels up to 400 copies/ml. The three subjects were in the MGS positive group. The two subjects showing HIV-1 RNA in seminal fluid from the MGS negative group also had concomitant HIV-1 RNA detection in plasma. Conclusion We found no notable difference in the pattern of genital shedding in the seminal compartment of HIV-1 infected men established on ART with and without a diagnosis for MGS following treatment with praziquantel.
Does lean improve efficiency or effectiveness from the patient perspective?
Authors: Xing Xianjin , Gao Tian , Wang Jian , Liu Jinyang , Han Jinming , Qu Ge 
Published: May 2022

Abstract
Background: The purpose of this paper is to assess the impacts of lean healthcare on patient satisfaction and determine whether it improve the efficiency or effectiveness in the eyes of the patient after lean interventions. Methods: A multi-method, systematic review of the English literature researching the relationship between lean healthcare and patient satisfaction was conducted from September to November 2021. From the initial identification of over 621 papers, 51 studies that met the search criteria were selected. We did a thematic content analysis of the 51 papers.Results: 41 out of 51 studies clearly reported that the application of lean would lead to improved patient satisfaction, one study sated that satisfaction remained unchanged, two studies reported a decrease and one stated that the impact is unclear. The factors, impacting the relationship between lean healthcare and patient satisfaction, were classified into 7 categories: medical staff service, service process, service outcome, hospital facilities and equipment, hospitalizations, patient complaints, respondents’ characteristics. Most studies have verified the impact of the improvement of service process factors caused by lean implementation on patient satisfaction, and only 7 studies have verified the impact of lean improved service results on patient satisfaction.Conclusion: Most of the research on lean improvement on patient satisfaction focuses on efficiency, not effectiveness—the effect of patient treatment. Although the efficiency improvement in lean improvement itself also starts from the patient, the improvement of effectiveness still needs more attention, and the focus of lean healthcare needs to return to the essence of medical treatment.
A New Necroptosis-Related lncRNA Signature Predicts the Prognosis and Tumor Immune Microenvironment of Breast Cancer Patients
Authors: Zhao Jinlai , Ma Haiyan , Feng Ruigang , Li Dan , Liu Bowen , Yu Yue , Cao Xuchen , Wang Xin 
Published: May 2022

Abstract
Background: The issue of relationship between necroptosis and lncRNAs has been a controversial subject within cancer-related research. Currently, the exact role of necroptosis and lncRNAs exerted in breast cancer (BC) remains to be discovered. Therefore, the necroptosis-related lncRNAs in BC are explored in this study.Methods: BC transcriptome data were obtained from the TCGA (The Cancer Genome Atlas) database to create synthetic matrices. Analysis approaches of univariate Cox regression and co-expression were combined to identify necroptosis-related prognostic lncRNAs. Then multivariate Cox regression and Lasso approaches were performed to acquire necroptosis-related lncRNAs, from which the predictive necroptosis-related lncRNA signature was constructed. Next, calibration curves, the time-dependent receiver operating characteristics (ROCs), ,and a nomogram were obtained, and the Kaplan-Meier analysis was performed to verify and evaluate the proposed model. Besides, the risk groups were analyzed with the Gene Set Enrichment Analyses (GSEA). Finally, these groups were studied by immune analysis to obtain the predicted half-maximal inhibitory concentration (IC50).Results: A model was proposed based on 10 necroptosis-related lncRNAs, and the calibration plots accorded well with the predicted prognosis. For the 1-, 3-, and 5-year prognosis, the area under the ROC curve (AUC) values were 0.71, 0.729 and 0.707 respectively. GSEA identified that the functions of target genes located primarily in immunity, metabolism, as well as tumor occurrence and development. The remarkable differences in IC50 and gene expression between risk groups gave a significant insight for further systemic treatments. Besides, higher macrophage scores were found in the high-risk group, in which the patients were more sensitive to conventional chemotherapy drugs (such as AKT inhibitor VIII and saracatinib) and anti-CD80, TNF SF4, and CD276 immunotherapies.Conclusion: The prognosis of BC patients can be independently predicted by the predictive signatures, which shines new insights on further exploration of how necroptosis-related lncRNAs exactly works in BC and clinical treatments of BC.
Preventing blastocyst culture failure risk in IVF cycles merits a strategy of cleavage backup combined with blastocyst culture
Authors: Ren-Tao Jin , Na-Ru Zhou , Xiao-Hua Jiang , Bo Xu , Fang-Ting Lu , Li-Hua Luo , Luan Hong-Bing , Xian-Hong Tong 
Published: May 2022

Abstract
Background
Blastocyst transfer is associated with a high cycle cancellation rate due to more early embryo arrest. However, cleavage backup combined with blastocyst culture maybe merit prevention blastocyst culture failure.
Methods
We retrospectively analyzed 7026 cycles between October 2017 and August 2020 in our center for reproductive medicine. Two day-3 embryos were transferred or cryopreserved in addition to at least 1 surplus embryo extended the culture for blastocysts. The primary objective was to analyze the factors of influencing blastocyst formation. The secondary objective was to study the fate of sibling cleavage embryos after sparing the embryo culture for blastocysts.
Results
In all included cycles, there was 12.43% occurrence without blastocyst formation (CNB), 5.19% of nonavailable blastocysts (NAB), and 82.38% cycles with at least 1 valuable blastocyst (CHB). The number of day-3 embryos was associated with blastocyst formation outcome (adjusted odds ratio [aOR] 1.71), and older women and short agonist ovary stimulation decreased the odds of blastocyst formation (aOR 0.97 and 0.18, respectively). Female age and numbers of embryos for blastocyst culture were related to blastocyst quality (aOR 0.98 and 1.36, respectively). Some couples underwent fresh cleavage transfer (CNB 453, NAB 203, CHB 2341), and the pregnancy rate was significantly higher with positive culture results (CHB 47.97%, NAB 34.48%, CNB 34.88%, P = 0.001). There was a lower chance of being pregnant for advanced aged women (aOR 0.94). Compared with mild ovary stimulation, the long stimulation protocol and modified ultralong protocol were beneficial for pregnancy after day-3 embryo transfer (aOR 1.62 and 2.77, respectively). Cleavage of embryos from cycles with available blastocysts increased the odds of implantation (CHB 35.25%, CNB 23.40%, NAB 24.88%, P < 0.001). Pregnancy from cycles of no available blastocyst was associated with higher odds of miscarriage (NAB 19.10%, CNB 9.84%, CHB 10.70%). Outcome of blastocyst formation had no influence on preterm birth rate (CNB 12.03%, NAB 18.21%, CHB 18.45%, respectively, P = 0.139), birth defects (CNB 1.05%, NAB 1.09% CHB 0.89% P = 0.966), or sex ratio of male proportion (CNB 0.57, NAB 0.55, CHB 0.53, P = 0.669).
Conclusions
The pregnancy outcome of sibling cleavage transfer is related to blastocyst formation of spare embryos. For negative blastocyst culture patients, there is a lower but acceptable live birth rate from sibling cleavage transfer. Cleavage backup combined with blastocyst culture may prevent blastocyst formation failure risk.