bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of KIF2A, NDC80, CDK1, and CCNB1 in breast cancer patients: Their interaction and linkage with tumor features and prognosis
Authors: Wang Cong , Xie Xianxin , Li Weijie , Jiang Daqing 
Published: August 2022

AbstractBackgroundKinesin family member 2A (KIF2A), nuclear division cycle 80 (NDC80), cyclin‐dependent kinase 1 (CDK1), and cyclin B1 (CCNB1) exhibit a complex interrelation, which promote cancer progression via multiple ways, whereas their interaction and clinical implications in breast cancer are obscure. Hence, this study aimed to evaluate the correlation among KIF2A, NDC80, CDK1, CCNB1, and their linkage with clinicopathological features and prognosis in breast cancer patients.Methods195 breast cancer patients underwent surgical resection were analyzed. KIF2A, NDC80, CDK1, and CCNB1 expressions were determined by immunohistochemical (IHC) assay and scored by a semiquantitative IHC score or positive cell percentage.ResultsKIF2A expression positively associated with NDC80, CDK1, and CCNB1 expressions (all p < 0.01). In terms of tumor features: KIF2A high expression linked with increased T stage (p = 0.011), N stage (p = 0.014), and TNM stage (p = 0.009) but not tumor differentiation (p = 0.651). NDC80 high expression only related to higher N stage (p = 0.010); CDK1 high expression only connected with elevated N stage (p = 0.035) and TNM stage (p = 0.023). In aspect of prognosis, high expression of KIF2A was correlated with worse disease‐free survival (DFS) (p = 0.031), while NDC80 high (p = 0.329), CDK1 high (p = 0.276), and CCNB1 positive (p = 0.063) expressions only showed trends to link with poor DFS (without statistical significance). Furthermore, high expression of KIF2A (p = 0.063), NDC80 (p = 0.939), CDK1 (p = 0.413) and positive expression of CCNB1 (p = 0.296) did not relate to overall survival.ConclusionKIF2A correlates with NDC80, CDK1, CCNB1, and may link with advanced tumor stages and poor prognosis in breast cancer patients.
Lung ultrasound versus chest computed tomography for pregnant inpatients with COVID‐19
Authors: Biancolin Sckarlet Ernandes , dos Santos Fernandes Hermann , Sawamura Marcio Valente Yamada , Queiroz Joelma , Centofanti Sandra Frankfurt , Liao Adolfo Wenjaw , da Costa Leite Claudia , Francisco Rossana Pulcineli Vieira , de Lourdes Brizot Maria ,   And the HC‐FMUSP‐Obstetric COVID19 Study Group: Aline Scalisse Bassi, Amanda Wictky Fabri, Ana Claudia Rodrigues Lopes Amaral de Souza, Ana Claudia Silva Farche, Ana Maria Kondo Igai, Ana Maria da Silva Sousa Oliveira, Adriana Lippi Waissman, Carlos Eduardo do Nascimento Martins, Cristiane de Freitas Paganoti, Danielle Rodrigues Domingues, Fernanda Cristina Ferreira Mikami, Fernanda Spadotto Baptista, Jacqueline Kobayashi Cippiciani, Jéssica Gorrão Lopes Albertini, Juliana Ikeda Niigaki, Marco Aurélio Knip
Published: August 2022

AbstractPurposeTo compare lung ultrasound (US) and computed tomography (CT) in the assessment of pregnant women with COVID‐19.MethodsProspective study comprising 39 pregnant inpatients with COVID‐19 who underwent pulmonary assessment with CT and US with a maximum span of 48 h between the exams. The thorax was divided into 12 regions and assessed in terms of the following: the presence of B‐lines (>2), coalescent B‐lines, consolidation on US; presence of interlobular thickening, ground glass, consolidation on CT. The two methods were scored by adding up the scores from each thoracic region.ResultsA significant correlation was found between the scores obtained by the two methods (rICC = 0.946; p < 0.001). They were moderately in agreement concerning the frequency of altered pulmonary regions (weighted kappa = 0.551). In US, a score over 15, coalescent B‐lines, and consolidation were predictors of the need for oxygen, whereas the predictors in CT were a lung score over 16 and consolidation. The two methods, US (p < 0.001; AUC = 0.915) and CT (p < 0.001; AUC = 0.938), were fairly accurate in predicting the need for oxygen.ConclusionIn pregnant women, lung US and chest CT are of similar accuracy in assessing lungs affected by COVID‐19 and can predict the need for oxygen.
Steroid therapy has an acceptable role as the initial treatment in autoimmune pancreatitis patients with pancreatic cyst formation: Based on a Japanese nationwide study
Authors: Kubota Kensuke , Oguchi Takaya , Fujimori Nao , Yamada Kenta , Naitoh Itaru , Okabe Yoshinobu , Iwasaki Eisuke , Masamune Atsushi , Ikeura Tsukasa , Kamisawa Terumi , Inoue Dai , Kumagi Teru , Ogura Takeshi , Kodama Yuzo , Katanuma Akio , Hirano Kenji , Inui Kazuo , Isayama Hiroyuki , Sakagami Junichi , Nishino Takayoshi , Kanno Atsushi , Kurita Yusuke , Okazaki Kazuichi , Nakamura Seiji ,   Collaborators
Published: August 2022

AbstractBackgroundWe attempted to determine the indications and limitations of steroid therapy as the first‐line therapy in patients with autoimmune pancreatitis (AIP) with cyst formation (ACF).MethodsThis Japanese multicenter survey was conducted to examine the merits/demerits of steroid treatment as the initial therapy for ACF.ResultsData of a total of 115 patients with ACF were analyzed. Complete remission was achieved in 86% (86/100) of patients who had received steroid treatment, but only 33.3% (5/15) of patients who had not received steroids. Relapse after the remission (n = 86) occurred in 7.6% (6/86) of patients who had received steroid therapy, but 40% (2/5) of patients who had not received steroid therapy. Multivariate analysis identified adoption of the wait and watch approach without steroid treatment (odds ratio = 0.126, P < .001) as a significant and independent negative predictor of remission of ACF. As for predictors of relapse, the presence of varix (odds ratio = 5.83, P = .036) was identified as an independent risk factor.ConclusionSteroid therapy plays an important role as first‐line therapy in AIP patients with pancreatic cyst formation, however, varix formation, besides the diameter of the cyst(s), is a risk factor for refractoriness to steroid therapy.
Assessment of Perineal Scars on Translabial Pelvic Floor Ultrasound: A Pilot Study
Authors: Housmans Susanne , Gillor Moshe , Shek Ka Lai , Dietz Hans Peter 
Published: August 2022

ObjectiveWe aimed to describe a method for identifying and evaluating perineal scars using translabial pelvic floor ultrasound. We hypothesized that translabial ultrasound can identify a perineal scar and can differentiate episiotomies from spontaneous tears.MethodsThis pilot study is a secondary analysis of data obtained in the Epi‐No® trial. Perineal integrity was assessed using volumes acquired on pelvic floor muscle contraction according to the method previously described for anal sphincter imaging. A scar was diagnosed if a hypoechoic distortion in the perineum was noted. We postulated that an episiotomy would result in a linear scar visible on four dimensional translabial ultrasound whereas nonlinear scars were considered the result of spontaneous perineal tear of grade 2 or higher. The results of this assessment were compared with data retrieved from electronic medical records.ResultsA scar was identified in 79/120 women (66%): 42 (35%) linear and 37 (31%) nonlinear. Sonographic and clinical diagnosis agreed on the presence or absence of perineal trauma in 66%. Agreement for the type of laceration was 50%.ConclusionIn this retrospective pilot study, a blinded assessment of translabial ultrasound volume data showed agreement between clinical data and sonographic assessment of perineal integrity in 66% and of type of laceration in 50%. More work is needed to optimize the method in assessment of perineal scars to improve its performance before it can be used in clinical audit and research.
Analysing overlay journals: The state‐of‐the‐art in 2021 and possible perspectives
Authors: Ursić Luka , Gudelj Danijel , Tomić Vicko , Marušić Matko , Marušić Ana 
Published: August 2022

AbstractThe rising importance of preprints and the growing number of journals accepting them necessitate a (re)definition of an overlay journal and its place in today's publishing context. Using a snowball search strategy, we searched Web of Science and Scopus databases for articles on overlay journals. From these articles, we identified 28 overlay journals that fit the traditional overlay journal definition (they did not host articles but provided links to final versions on repositories or they searched repositories for viable preprints to publish) or that defined themselves as overlay journals. Most journals were not indexed in bibliographic databases, and crucial information such as journal ownership was not publicly available. Likewise, most journals both self‐hosted articles and provided links to final versions on repositories, which might mean repositories are more valuable in their ‘open access’ functionality than in the capacity for hosting articles. Editorial policies and practices of these overlay journals were often undeveloped or non‐existent. It seems overlay journals remain a niche publishing model in 2021, especially due to the increased number of journals accepting preprints and using preprint servers in their core functionality. However, overlay journals can take an ‘active’ approach in finding, reviewing, and publishing preprints, replacing other inefficient publishing models.
Point‐of‐care ultrasound scan as the primary modality for evaluating parotid tumors
Authors: Harb Jennifer L. , Zaro Christopher , Nassif Samih J. , Dhingra Jagdish K. 
Published: August 2022

AbstractObjectivesThis study aimed to explore ultrasonography as a single imaging modality for the initial assessment of parotid lesions compared to computed tomography (CT) and magnetic resonance imaging (MRI).MethodsA retrospective cross‐sectional study was performed on 264 parotid gland lesions evaluated in a dedicated point‐of‐care ultrasound (POCUS) clinic with concurrent fine needle biopsy (FNB). Two hundred and nine of these lesions also underwent CT or MRI imaging. Histopathology results, when available, were recorded and compared to imaging impressions.ResultsSurgeon‐performed POCUS classified parotid masses accurately when compared to final histopathology (90/96, 94%). Using predefined criteria, POCUS determined the nature of parotid lesions more definitively than the descriptive CT or MRI radiology reports (p <.001). Sub‐analysis showed that ultrasonography was able to distinguish between benign pathologies with high degree of accuracy (Warthin tumor—82%, pleomorphic adenoma—64%).ConclusionsPOCUS can accurately distinguish between benign and malignant parotid lesions. POCUS may suffice as the only imaging study for benign lesions, obviating the need for additional cross‐sectional imaging. This can be combined with fine needle or core biopsy in the same visit, resulting in expedient diagnosis, low cost, and lack of radiation exposure.Level of Evidence2b, individual cross‐sectional cohort study.
A phase‐field approach for compaction band formation due to grain crushing
Authors: Ip Sabrina C.Y. , Borja Ronaldo I. 
Published: August 2022

AbstractCompaction bands are tabular regions of localized compressive deformation with little or no shear offset. Often observed in high‐porosity rocks, they can be classified into several subtypes based on their pattern and orientation with respect to the maximum principal stress. The combined effects of material properties and loading conditions on the type of compaction bands that develop are not fully understood, and realistic simulations of their formation are not always successful. In this study, a phase‐field approach for capturing the formation and propagation of compaction bands is proposed. The fracture energy utilized in classic phase‐field formulations is interpreted to be driven by grain crushing and is herein characterized by breakage mechanics theory. A new decomposition of the free energy function is introduced in which the energy stored by plastic compactive flow drives grain crushing. Depending on the value of the energy release rate, the model predicts different styles of compaction bands that are remarkably consistent with those observed in the field. Numerical simulations demonstrate the role of confining pressure, plasticity, and critical breakage energy on the styles of the predicted compaction bands.
A physics‐based model reduction approach for node‐to‐segment contact problems in linear elasticity
Authors: Manvelyan Diana , Simeon Bernd , Wever Utz 
Published: August 2022

AbstractThe article presents a novel model order reduction method for mechanical problems in linear elasticity with nonlinear contact conditions. Recently, we have proposed an efficient reduction scheme for the node‐to‐node formulation [Manvelyan et al., Comput Mech 68, 1283–1295 (2021)] that leads to linear complementarity problems (LCPs). Here, we enhance the underlying contact problem to a node‐to‐segment formulation, which leads to quadratic inequalities as constraints. The adjoint system corresponds to a nonlinear complementarity problem that describes the Lagrange multiplier. The latter is solved by a Newton‐type iteration based on a LCP solver in each time step. Since the maximal set of potential contact nodes is predefined, an additional substructuring by Craig–Bampton can be performed. This contact treatment turns out to be necessary and allows exclusion of the Lagrange multipliers and the nodal displacements at contact from reduction. The numerical solutions of the reduced contact problem achieve high accuracy and the dynamic contact carries over the behavior of the full order model. Moreover, if the contact area is small compared to the overall structure, the reduction scheme performs very efficiently. The performance of the resulting reduction method is assessed on two 2D computational examples from linear elasticity.
A method for quantifying how the activity of an enzyme is affected by the net charge of its nearest crowded neighbor
Authors: Koone Jordan C. , Dashnaw Chad M. , Gonzalez Mayte , Shaw Bryan F. 
Published: August 2022

AbstractThe electrostatic effects of protein crowding have not been systematically explored. Rather, protein crowding is generally studied with co‐solvents or crowders that are electrostatically neutral, with no methods to measure how the net charge (Z) of a crowder affects protein function. For example, can the activity of an enzyme be affected electrostatically by the net charge of its neighbor in crowded milieu? This paper reports a method for crowding proteins of different net charge to an enzyme via semi‐random chemical crosslinking. As a proof of concept, RNase A was crowded (at distances ≤ the Debye length) via crosslinking to different heme proteins with Z = +8.50 ± 0.04, Z = +6.39 ± 0.12, or Z = −10.30 ± 1.32. Crosslinking did not disrupt the structure of proteins, according to amide H/D exchange, and did not inhibit RNase A activity. For RNase A, we found that the electrostatic environment of each crowded neighbor had significant effects on rates of RNA hydrolysis. Crowding with cationic cytochrome c led to increases in activity, while crowding with anionic “supercharged” cytochrome c or myoglobin diminished activity. Surprisingly, electrostatic crowding effects were amplified at high ionic strength (I = 0.201 M) and attenuated at low ionic strength (I = 0.011 M). This salt dependence might be caused by a unique set of electric double layers at the dimer interspace (maximum distance of 8 Å, which cannot accommodate four layers). This new method of crowding via crosslinking can be used to search for electrostatic effects in protein crowding.
GM‐CSF antibodies in artificial stone associated silicoproteinosis: A case report and literature review
Authors: Khan Shana N. S. , Stirling Robert G. , Mclean Catriona A. , Russell Prudence A. , Hoy Ryan F. 
Published: August 2022

AbstractPulmonary alveolar proteinosis (PAP) is a rare lung disease where there is accumulation of surfactant in the alveoli. It can be classified based on the underlying aetiology into three categories: primary, secondary and congenital. Autoantibodies to granulocyte‐macrophage colony‐stimulating factor (GM‐CSF‐Ab) are a key diagnostic feature of autoimmune PAP. High intensity occupational exposure and inhalation of toxic particles such as silica can cause a form of secondary PAP called acute silicoproteinosis. We describe a 26‐year‐old stone benchtop fabricator with silicoproteinosis following daily exposure to high levels of silica who had elevated serum GM‐CSF‐Ab. We discuss the role of GM‐CSF‐Ab in cases of PAP with occupational inhalational exposure and the challenges in its interpretation.
On event‐triggered guaranteed cost control for discrete‐time semi‐Markovian neural networks having communication delays and dual‐terminal probabilistic faults
Authors: Li Xiaoqing , She Kun , Shi Kaibo , Cheng Jun , Yu Yongbin , Peng Zhinan 
Published: August 2022

AbstractThis article aims to address the guaranteed cost control synthesis problem for discrete‐time semi‐Markovian neural networks (D‐SMNNs) considering communication delays along with probabilistic faulty sensors and actuators (dual‐terminal probabilistic faults) by adopting a modified event‐triggered mechanism. Our primary target of this research is to implement a suitable feedback controller such that the resulting D‐SMNNs achieve stochastically stable. To be more concrete, the structural and coefficient switchings of the NNs are characterized by a semi‐Markovian process (SMP) along with the lower and upper bounds of the transition probabilities (TPs), which can reflect the reality more accurately and has a wider application scope. For optimize the resource utilization of the band‐limited communication networks, a modified event‐triggered transmission strategy is put forward to lessen the unnecessary data transmission over network. Additionally, according to different failure rates and the measurement distributions of intelligent modules, a more practical probabilistic sensors and actuators faulty model for networked D‐SMNNs is synthesized, which including additivity and multiplicity. The anamorphic probability of sensors and actuators are governed by a battery of mutually independent stochastic variables that obeys certain probabilistic distribution over the preknown interval . Therein, the distortion degree and failure rate for each sensor and actuator can be separately quantized and characterized with the aid of mathematical variance and expectation. Briefly, in comparison to the existing faulty models, the novelty of this extended fault model lies in it can characterize more features in practical industrial applications. Afterwards, by resorting to the Lyapunov functional method and combining with both the stochastic analysis technique and matrix inequality decoupling manipulation, several sufficient conditions on ensuring stabilization for solving both the guaranteed cost controller gains and event‐triggered coefficients are formulated in the shape of a group of linear matrix inequalities (LMIs), which can be verified by exploiting standard compute software. After that, the controller design is reformulated as an optimization problem with LMI constraints immediately. Eventually, three simulation examples are carried out to substantiate the potency and accuracy of the proposed control synthesis methodology.
Storylines nailing or failing sustainability: Energy, mining and mobility as narrative arenas for societal transition
Authors: Lyytimäki Jari 
Published: August 2022

AbstractThe urgency of the sustainability transition, as emphasized by science, has not yet been fully translated to large‐scale, inspired and effective societal action. This article focuses on the transformative potential of science‐based information presented through specific sustainability storylines inside larger policy narratives. Sustainability storylines can serve as tools for learning from the past, create representations of the current situation and outline paths toward probable, preferable, or avoidable futures. The focus is on three storylines focusing on bioenergy as a renewable energy solution, green mining providing nonrenewable resources and physically active mobility allowing health and environmental benefits. The empirical focus is on Finland, a forerunner of sustainability policies with a large per capita environmental footprint. The potential of sustainable development goals to simultaneously serve as a globally shared and nationally relevant framework for sustainability storylines is discussed with a rather dismal conclusion but optimistic outlook.
Biostimulatory Micro‐Fragmented Nanofiber‐Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling
Authors: Yao Zhi‐Cheng , Yang Yueh‐Hsun , Kong Jiayuan , Zhu Yining , Li Ling , Chang Calvin , Zhang Chi , Yin Jason , Chao Jeffrey , Selaru Florin M. , Reddy Sashank K. , Mao Hai‐Quan 
Published: August 2022

AbstractFunctional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue. A biostimulatory nanofiber‐hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface‐functionalized poly (ε‐caprolactone) nanofiber fragments. The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties. Here, injectability of the pre‐formed NHC is improved by mechanical fragmentation, making it into micro‐fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling. The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC. When injected subcutaneously in a rat model, mfNHC‐MSC constructs initiate an elevated level of host macrophage infiltration, more pro‐regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone. A similar trend of host cell infiltration and pro‐angiogenic response is detected in a swine model with a larger volume injection. These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
Polymorphic Phosphorus Applied to Alkali‐Ion Battery Electrodes
Authors: Tsai Hsu‐Sheng 
Published: August 2022

AbstractThe polymorphic phosphorus materials such as amorphous red and black ones have been used as the anodes for alkali‐ion batteries. As the research field of 2D materials is pioneered, the fibrous red and violet phosphorus begin to be investigated and predicted for various devices. Meanwhile, they are not only applied to the active materials of electrodes but also the formation of protective layers for battery application. This article briefly introduces the primary allotropes of phosphorus, their research progress, and their potential for the application of alkali‐ion batteries. Next, the recent studies concerning their applications of electrodes and protective layers for alkali‐ion batteries are discussed in detail. Finally, the merits and drawbacks of preparation approaches, the strategies for improvement of battery performance, and the urgent challenges as well as possible solutions for future development of alkali‐ion batteries using the electrodes or protective layers made from phosphorus materials, are summarized.