bluuebunny/crossref_metadata_2025_split huggingface dataset:
A low-energy-dense dietary pattern: a narrative review
Authors: Burns Kaelyn F , Robson Shannon M , Raynor Hollie A 
Published: May 2022

Abstract

Background
Dietary recommendations have promoted the consumption of a low-energy-dense dietary pattern; however, guidelines to implement this dietary pattern are lacking.

Objectives
The objectives of this narrative review are to discuss approaches used to implement a low-energy-dense dietary pattern within dietary interventions and to understand if these approaches achieve a lower energy-dense diet.

Methods
Interventions that modified the diet for the purpose of altering energy density were referenced. Articles were chosen on the basis of the authors’ knowledge of the energy density literature, reviewing relevant articles’ reference lists, and discussion among coauthors.

Results
Eight articles were chosen for this review. Two approaches have been used to alter energy density: 1) modification to the consumption of dietary components that influence energy density (eg, reducing fat, increasing fruits and vegetables) or 2) use of an energy density classification method based on the numeric energy density value of foods. Although both approaches were used successfully to lower energy density, only the approach that used an energy density classification method allowed for the establishment of specific behavioral goals for participants to achieve regarding energy density.

Conclusion
The use of an energy density classification method to develop specific intake goals may aid in the behavioral implementation of a low-energy-dense dietary pattern, but more high-quality studies are needed to draw stronger conclusions. Furthermore, barriers to consuming a low-energy-dense dietary pattern, such as dietary costs, need to be considered.
Osa-miR1320targets the ERF transcription factor OsERF096 to regulate cold tolerance via JA-mediated signaling
Authors: Sun Mingzhe , Shen Yang , Chen Yue , Wang Yan , Cai Xiaoxi , Yang Junkai , Jia Bowei , Dong Weifeng , Chen Xi , Sun Xiaoli 
Published: May 2022

AbstractMicroRNAs play key roles in abiotic stress response. Rice (Oryza sativa L.) miR1320 is a species-specific miRNA that contributes to miR168-regulated immunity. However, it is still unknown whether miR1320 is involved in rice response to abiotic stress. In this study, we illustrated that the miR1320 precursor generated two mature miR1320s, miR1320-3p, and miR1320-5p, and they both displayed decreased expression under cold stress. Genetic evidence showed that miR1320 overexpression resulted in increased cold tolerance, while miR1320 knock down (KD) reduced cold tolerance. Furthermore, an APETALA2/ethylene-responsive factor (ERF) transcription factor OsERF096 was identified as a target of miR1320 via 5′-RACE and dual luciferase assays. OsERF096 expression was altered by miR1320 overexpression and KD and exhibited an opposite pattern to that of miR1320 in different tissues and under cold stress. Consistently, OsERF096 negatively regulated cold stress tolerance. Furthermore, we suggested that OsERF096 could bind to the GCC and DRE cis-elements and act as a transcriptional activator in the nucleus. Based on RNA-sequencing and targeted metabolomics assays, we found that OsERF096 modified hormone content and signaling pathways. Finally, phenotypic and reverse transcription-quantitative PCR assays showed that jasmonic acid (JA) methyl ester application recovered the cold-sensitive phenotype and JA-activated expression of three Dehydration Responsive Element Binding genes in the OsERF096-OE line. Taken together, our results strongly suggest that the miR1320–OsERF096 module regulates cold tolerance by repressing the JA-mediated cold signaling pathway.
Use of science in public policy: Lessons from the COVID-19 pandemic efforts to ‘Follow the Science’
Authors: Bozeman Barry 
Published: May 2022

AbstractThe paper asks: ‘What can we learn from COVID-19 pandemic about effective use of scientific and technical information (STI) in policymaking and how might the lessons be put to use?’ The paper employs the political rhetoric of ‘follow the science’ as a lens for examining contemporary concerns in the use of STI, including (1) ‘Breadth of Science Products’, the necessity of a broader concept of STI that includes by-products science, (2) ‘Science Dynamism’, emphasizing the uncertainty and impeachability of science, (3) ‘STI Urgency’ suggesting that STI use during widespread calamities differs from more routine applications, and (4) ‘Hyper-politicization of Science’, arguing that a step-change in the contentiousness of politics affects uses and misuses of STI. The paper concludes with a discussion, STI Curation, as a possible ingredient to improving effective use. With more attention to credibility and trust of STI and to the institutional legitimacy of curators, it should prove possible to improve the effective use of STI in public policy.
Are Newborn Outcomes Different for Term Babies Who Were Exposed to Antenatal Corticosteroids?
Authors: McKinzie Alexandra H. , Yang Ziyi , Teal Evgenia , Daggy Joanne K. , Tepper Robert S. , Quinney Sara K. , Rhoads Eli , Haneline Laura S. , Haas David M. 
Published: May 2022

(Abstracted from Am J Obstet Gynecol 2021;225:536.e1–536.e7)
The administration of antenatal corticosteroids can improve newborn lung function following antenatal treatment of pregnant women who are between 24 and 36 + 6/7 weeks' gestation and at risk of preterm delivery within 7 days. Antenatal corticosteroids, such as betamethasone (BMZ), reduce the risks of respiratory distress syndrome, the need for respiratory support, and admission to the neonatal intensive care unit (NICU).
Association Between Income and Perinatal Mortality in the Netherlands Across Gestational Age
Authors: Vidiella-Martin Joaquim , Been Jasper V. , Van Doorslaer Eddy , García-Gómez Pilar , Van Ourti Tom 
Published: May 2022

(Abstracted from JAMA Network Open 2021;4(11):e2132124)
While the contribution of socioeconomic status to disparities in neonatal death and stillbirth has received considerable attention, several key aspects remain understudied. These include the specificity of the association between household income and perinatal outcomes and the contribution of gestational age and birth weight to income-related disparities in perinatal mortality.
Medical Student Identity Construction Within Longitudinal Integrated Clerkships: An International, Longitudinal Qualitative Study
Authors: Brown Megan E.L. , Ard Catherine , Adams Jennifer , O’Regan Andrew , Finn Gabrielle M. 
Published: May 2022

Purpose
Longitudinal integrated clerkships (LICs) have been implemented worldwide to increase authentic student participation in patient care over time. Studies have shown benefits of the model include the ability of LICs to attract future practitioners to underserved areas, student engagement in advocacy, and development of an “ethic of caring.” Less is known, however, about how LICs impart their benefits, although LICs may strengthen professional identity. As such, this study aimed to explore medical student professional identity construction through time within LICs internationally.

Method
This was a longitudinal qualitative study from 2019 to 2020, involving 33 students across 4 medical schools in the United Kingdom, Ireland, and the United States. The authors explored participating students’ identity construction during LICs. Data collection involved 3 stages: individual, semistructured interviews at entry (n = 33) and exit of the LIC (n = 29), and audio diaries throughout. Data were analyzed inductively using a reflexive thematic approach.

Results
Three themes were identified. Longitudinal relationships with patients and preceptors encouraged patient care ownership and responsibility; LIC students identified as patient advocates; and longitudinal relationships shaped students’ social consciences. Themes were underpinned by continuity of relationships between students and patients, and students and tutors.

Conclusions
Though continuity is lauded as the cornerstone of LICs, these findings suggest that this is too broad a way of understanding the benefits of LICs. Instead, continuity should be seen as facilitating the development of important relationships within diverse communities of practice, which leads medical students to construct professional identities as responsible, compassionate advocates for underserved populations. This was the case across the institutions, nations, and LIC types in this study. By highlighting the ways in which LICs influence identity, these findings offer important insight relating to the future development and delivery of LICs.
ACR-ACNM-ASTRO-SNMMI Practice Parameter for Lutetium-177 (Lu-177) DOTATATE Therapy
Authors: Love Charito , Desai Neil B. , Abraham Tony , Banks Kevin P. , Bodei Lisa , Boike Thomas , Brown Richard K.J. , Bushnell David L. , DeBlanche Lorraine E. , Dominello Michael M. , Francis Tony , Grady Erin C. , Hobbs Robert F. , Hope Thomas A. , Kempf Jeffrey S. , Pryma Daniel A. , Rule William , Savir-Baruch Bital , Sethi Ila , Subramaniam Rathan M. , Xiao Ying , Schechter Naomi R. 
Published: May 2022

Objectives:
This practice parameter (PP) for Lutetium-177 (Lu-177) DOTATATE peptide receptor radionuclide therapy (PRRT) aims to guide authorized users in selection of appropriate adult candidates with gastroeneropancreatic neuroendocrine tumors (GEP-NETs) from foregut, midgut, and hindgut. The essential selection criteria include somatostatin receptor-positive GEP-NETs, which are usually inoperable and progressed despite standard therapy. Lu-177 DOTATATE is a radiopharmaceutical with high avidity for somatostatin receptors that are overexpressed by these tumors. This document ensures safe handling of Lu-177 DOTATATE by the authorized users and safe management of affected patients.

Methods:
The document was developed according to the systematic process developed by the American College of Radiology (ACR) and described on the ACR Web site (https://www.acr.org/Clinical-Resources/Practice-Parameters-and-Technical-Standards). The PP development was led by 2 ACR Committees on Practice Parameters (Nuclear Medicine and Molecular Imaging and Radiation Oncology) collaboratively with the American College of Nuclear Medicine, American Society of Radiation Oncology, and Society of Nuclear Medicine and Molecular Imaging.

Results:
The Lu-177 DOTATATE PP reviewed pharmacology, indications, adverse effects, personnel qualifications, and required clinical evaluation before starting the treatment, as well as the recommended posttherapy monitoring, quality assurance, documentation, and appropriate radiation safety instructions provided in written form and explained to the patients.

Conclusions:
Lu-177 DOTATATE is available for therapy of inoperable and/or advanced GEP-NETs when conventional therapy had failed. It can reduce tumor size, improve symptoms, and increase the progression free survival. The PP document provides clinical guidance for authorized users to assure an appropriate, consistent, and safe practice of Lu-177 DOTATATE.
Per- and polyfluoroalkyl substances in drinking water and hypertensive disorders of pregnancy in the United States during 2013–2015
Authors: Zhu Yachen , Bartell Scott M. 
Published: May 2022

Background:
Per- and polyfluoroalkyl substances (PFAS) widely exist in the environment and human bodies. Contaminated drinking water is one of the major exposure pathways for humans. Previous studies found weak or moderate associations between PFAS and hypertensive disorders of pregnancy (HDP).

Methods:
We obtained the number of births and counts of HDP cases for singleton births multiply stratified by county, maternal age, race, education, smoking status, and parity from CDC WONDER, and PFAS water concentrations from EPA UCMR3 data in the United States during 2013–2015. We used binomial regression on the multiply stratified HDP data to produce equal effect estimates and standard errors to those that would be derived from using individual-level data on binary HDP status and demographic covariates in logistic regression.

Results:
After adjusting for demographic covariates, we found small but statistically significant positive associations between HDP and population-weighted average water concentrations (ng/L) of all four PFAS: Odds ratio (OR) = 1.009, 95% CI = (1.001, 1.016) per IQR increase in perfluorooctanoic acid (PFOA); 1.030, 95% CI = (1.021, 1.040) per IQR increase in perfluorooctane sulfonate (PFOS); 1.008, 95% CI = (1.005, 1.011) per IQR increase in perfluoroheptanoic acid (PFHpA); 1.007, 95% CI = (1.004, 1.010) per IQR increase in perfluorohexane sulfonic acid (PFHxS), and 1.032, 95% CI = (1.022, 1.042) per IQR increase in the sum of four PFAS. Further adjustment for coexposures reversed the effect of PFOA from positive to inverse, and attenuated the effects of PFOS and PFHxS toward the null. After drinking water to serum concentration conversions, our effect estimates for PFOA, PFOS, and PFHxS are similar to previous studies.

Conclusions:
We found a weak positive association between the PFAS mixture and HDP, although the generalizability is subject to inherent limitations of the public-available datasets.
E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons
Authors: Zhang Luyao , Li Xiang , Feng Xiaozhou , Berkman Tolga , Ma Ruining , Du Shibin , Wu Shaogen , Huang Congcong , Amponsah Akwasi , Bekker Alex , Tao Yuan-Xiang 
Published: May 2022

Abstract
Nerve trauma-induced alternations of gene expression in the neurons of dorsal root ganglion (DRG) participate in nerve trauma-caused nociceptive hypersensitivity. Transcription factors regulate gene expression. Whether the transcription factor E74-like factor 1 (ELF1) in the DRG contributes to neuropathic pain is unknown. We report here that peripheral nerve trauma caused by chronic constriction injury (CCI) of unilateral sciatic nerve or unilateral fourth lumbar spinal nerve ligation led to the time-dependent increases in the levels of Elf1 mRNA and ELF1 protein in injured DRG, but not in the spinal cord. Preventing this increase through DRG microinjection of adeno-associated virus 5 expressing Elf1 shRNA attenuated the CCI-induced upregulation of matrix metallopeptidase 9 (MMP9) in injured DRG and induction and maintenance of nociceptive hypersensitivities, without changing locomotor functions and basal responses to acute mechanical, heat, and cold stimuli. Mimicking this increase through DRG microinjection of AAV5 expressing full-length Elf1 upregulated DRG MMP9 and produced enhanced responses to mechanical, heat, and cold stimuli in naive mice. Mechanistically, more ELF1 directly bond to and activated Mmp9 promoter in injured DRG neurons after CCI. Our data indicate that ELF1 participates in nerve trauma-caused nociceptive hypersensitivity likely through upregulating MMP9 in injured DRG. E74-like factor 1 may be a new target for management of neuropathic pain.
Perception and Utilization of Standardized Outcome Measures in Acute Care Physical Therapy
Authors: Smith Darby , Furtado Michael , Brusola Gregory 
Published: May 2022

Purpose:
To assess the relationship between characteristics of acute care physical therapists (PTs) and use of standardized outcome measures (OMs); also describe the perceived barriers, facilitators, and resources to the use of OMs by PTs in the acute care setting.

Methods:
An electronic survey was distributed to PTs who currently work, or have worked, in the adult acute care setting in the past 5 years. Separate quantitative and qualitative analyses were performed followed by triangulation of findings.

Results:
A convenience sample included 227 respondents. Most respondents (n = 159, 70%) reported using OMs. PTs with a clinical specialty used OMs significantly more (P = .041) than those without. No significant difference was found in the frequency of OM use between years of experience, entry-level degree, and primary patient population. The top barrier was lack of time (60%). The top facilitator was support from administration (81%). Themes generated for barriers, facilitators, and resources included lack of resources, setting specificity, patient population and acuity, objective data, facility support, and continuing education.

Conclusions:
Most acute care PTs reported using OMs, although a higher frequency was observed in those with a clinical specialty. This study presents opportunities to provide knowledge translation and resources to combat barriers to OM use in the acute care setting.
Comparison of single platelet-rich plasma injection with hyaluronic acid injection for partial-thickness rotator cuff tears
Authors: Huang Shou-Hsien , Hsu Po-Cheng , Wang Kevin A. , Chou Chen-Liang , Wang Jia-Chi 
Published: May 2022

Background:
Partial-thickness rotator cuff tears (PTRCTs) is not uncommon, and various nonsurgical injection therapy for PTRCTs emerged. Platelet-rich plasma (PRP) and hyaluronic acid (HA) injection were proposed for treating PTRCTs; however, the relation of dose among injectates was still lacking.

Methods:
This was a prospective, nonrandomized, comparative study. The aim of the study was to compare the effects of ultrasound-guided single PRP injection with three doses of HA injection, combination of postinjection rehabilitation, for treating PTRCTs. Subjects received either ultrasound-guided PRP injection and rehabilitation exercise, or ultrasound-guided subacromial HA injection and rehabilitation exercise. Shoulder Pain and Disability Index (SPADI), range of motion (ROM), pain visual analog scale (VAS), and Constant-Murley Shoulder Score (CMSS) were recorded before injection, and at 1 and 3 months after injection.

Results:
Forty-eight patients were enrolled. They received either ultrasound-guided single PRP (n = 24) intralesional and peritendinous injection or three doses of HA (n = 24) subacromial injection plus rehabilitation exercise. In the PRP group, SPADI scores, VAS scores, CMSS significantly improved at 1-month and 3-month follow up; flexion and abduction ROM significantly increased at 3-month follow up. In the HA group, SPADI scores, VAS during overhead activities, VAS night pain, and CMSS significantly improved in the first and third months; flexion and active abduction ROM significantly increased in the third month. The PRP group revealed significantly better passive abduction ROM and CMSS at third month than HA group.

Conclusion:
Ultrasound-guided single PRP injection exhibited comparable benefit to three doses of HA injection in patients with PTRCTs short-termly, with an extended effect regarding passive shoulder abduction ROM and CMSS.
The impact of hepatotoxic drugs on the outcome of patients with acute deterioration of hepatitis B virus-related chronic disease
Authors: Sun Jian , Yu Xueping , Weng Zhangyan , Jin Lei , Yang Jian , Zhang Huatang , Gu Jun , Wang Ni , Yang Jianghua 
Published: May 2022

Background and aims
Hepatotoxic drugs can worsen outcomes in patients with chronic liver disease (CLD), whereas this negative effect in acute deterioration of hepatitis B virus (HBV)-related CLD (HBV-CLD) is rarely reported. We aimed to assess the impact of hepatotoxic drugs on the outcome of patients with acute deterioration of HBV-CLD.

Methods
This retrospective study included consecutive patients admitted to three medical centers in eastern China from 2015 to 2020 for HBV-related severe liver injury (HBV-SLI) or acute decompensation of cirrhosis (HBV-AD). The prevalence of hepatotoxic drugs and their impact on organ failure, the development of acute-on-chronic liver failure (ACLF), and 90-day survival were evaluated.

Results:
A total of 335 patients with HBV flare (median age, 44 years; 85.7% male; 38.2% HBV-SLI and 61.8% HBV-AD) were included. Of them, 72 (21.5%) received hepatotoxic drugs, with herbs (44.4%) being the most common form. Patients in the drugs group had a significantly higher prevalence of all types of organ failure except respiratory failure. The multivariate logistic model showed that hepatotoxic drugs raised the risk of developing ACLF by 7.66-fold. ACLF occurrence was the strongest risk factor for 90-day mortality with a hazard ratio of 5.54 in the Cox regression analysis. In contrast, the hepatitis B envelope antigen status and HBV DNA levels had weak associations with the development of organ failure and ACLF.

Conclusions:
Hepatotoxic drugs are closely associated with the development of organ failure and ACLF, and contribute to reduced 90-day survival rates among patients with acute deterioration of HBV-CLD.
Diagnostic value of lacrimal scintigraphy in the evaluation of lacrimal drainage system obstruction: a systematic review and meta-analysis
Authors: Mirshahvalad Seyed Ali , Chavoshi Mohammadreza , Bahmani Kashkouli Mohsen , Fallahi Babak , Emami-Ardakani Alireza , Manafi-Farid Reyhaneh 
Published: May 2022

Purpose
A systematic review and meta-analysis to evaluate the diagnostic performance of lacrimal scintigraphy (LS) versus anatomical methods in the evaluation of the nasolacrimal duct obstruction (NLDO).

Materials and methods
A systematic search was performed using electronic bibliographic databases until the end of May 2021. Inclusion criteria: (a) used LS as a diagnostic method to evaluate NLDO; (b) used anatomical studies [including syringing, irrigation, probing, and dacryocystography (DCG)] as reference tests; and (c) provided adequate crude data. A hierarchical method was used to pool the sensitivity and specificity. The hierarchical summary receiver-operating characteristic model was performed. Additionally, the studies’ heterogeneity and publication bias were analyzed. All analyses were conducted by the ‘Midas’ module of STATA 16.

Results
Twelve articles (with 14 separate populations) were considered eligible to enter the meta-analysis. They were divided into two groups based on the reference standard method, called irrigation and DCG groups. In the irrigation group, the pooled sensitivity and specificity were 89% [95% confidence interval (CI), 72–96%] and 25% (95% CI, 8–56%), respectively. In DCG group, the pooled sensitivity and specificity were 97% (95% CI, 85–100%) and 27% (95% CI, 0.12–0.49), in turn.

Conclusion
LS is a sensitive modality to evaluate the anatomical obstruction of NLD. In contrast, it shows low pooled specificity compared with anatomical methods. Thus, LS can be used as the first noninvasive modality for the evaluation of epiphora. However, in case of any abnormality, confirmatory procedures are required.