bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Photophysics of Nucleic Acids: Consequences for the Emergence of Life
Authors: Kufner Corinna L. , Bucher Dominik B. , Sasselov Dimitar D. 
Published: October 2022

AbstractAbsorption of ultraviolet (UV) radiation can trigger a variety of photophysical and photochemical reactions in nucleic acids. In the prebiotic era, on the surface of the early Earth, UV light could have played a major role in the selection of the building blocks of life via a balance between synthetic and destructive pathways. As nucleic acid monomers assembled into polymers, their survival and facility for non‐enzymatic replication hinged on their photostability and the ability for self‐repair of lesions, e. g., by UV‐induced charge transfer. Such photoprocesses are known to be sequence‐dependent and could have led to an additional prebiotic selection of the genetic sequence pools available to the earliest life forms. This review summarizes the photophysical processes in nucleic acids upon the absorption of a UV photon and their implications for chemical and genetic selection at the emergence of life and the origin of translation.
Artificial virtuous agents in a multi-agent tragedy of the commons
Authors: Stenseke Jakob 
Published: October 2022

AbstractAlthough virtue ethics has repeatedly been proposed as a suitable framework for the development of artificial moral agents (AMAs), it has been proven difficult to approach from a computational perspective. In this work, we present the first technical implementation of artificial virtuous agents (AVAs) in moral simulations. First, we review previous conceptual and technical work in artificial virtue ethics and describe a functionalistic path to AVAs based on dispositional virtues, bottom-up learning, and top-down eudaimonic reward. We then provide the details of a technical implementation in a moral simulation based on a tragedy of the commons scenario. The experimental results show how the AVAs learn to tackle cooperation problems while exhibiting core features of their theoretical counterpart, including moral character, dispositional virtues, learning from experience, and the pursuit of eudaimonia. Ultimately, we argue that virtue ethics provides a compelling path toward morally excellent machines and that our work provides an important starting point for such endeavors.
Significantly lower antigenicity of incobotulinumtoxin than abo- or onabotulinumtoxin
Authors: Hefter Harald , Rosenthal Dietmar , Jansen Alexander , Brauns Raphaela , Ürer Beyza , Bigalke Hans , Hartung Hans-Peter , Meuth Sven G. , Lee John-Ih , Albrecht Philipp , Samadzadeh Sara 
Published: October 2022

Abstract
Background
For many indications, BoNT/A is repetitively injected with the risk of developing neutralizing antibodies (NABs). Therefore, it is important to analyze whether there is a difference in antigenicity between the different licensed BoNT/A preparations.

Methods
In this cross-sectional study, the prevalence of NABs was tested by means of the sensitive mouse hemidiaphragm assay (MHDA) in 645 patients. Patients were split into those having exclusively been treated with the complex protein-free incoBoNT/A preparation (CF-MON group) and those having started BoNT/A therapy with a complex protein-containing BoNT/A preparation (CC-I group). This CC-I group was split into those patients who remained either on abo- or onaBoNT/A (CC-MON group) and those who had been treated with at least two BoNT/A preparations (CC-SWI group). To balance treatment duration, only CC-MON patients who did not start their BoNT/A therapy more than 10 years before recruitment (CC-MON-10 group) were further analyzed. The log-rank test was used to compare the prevalence of NABs in the CF-MON and CC-MON-10 group.

Results
In the CF-MON subgroup, no patient developed NABs. In the CC-I group, 84 patients were NAB-positive. NABs were found in 33.3% of those who switched preparations (CC-SWI) and in 5.9% of the CC-MON-10 group. Kaplan–Meier curves for remaining NAB-negative under continuous BoNT/A therapy were significantly different (p < 0.035) between the CF-MON and CC-MON-10 group.

Conclusion
Frequent injections of a complex protein-containing BoNT/A preparation are associated with significantly higher risks of developing NABs than injections with the same frequency using the complex protein-free incoBoNT/A preparation.
Endolymphatic space is age-dependent
Authors: Dieterich Marianne , Hergenroeder Tatjana , Boegle Rainer , Gerb Johannes , Kierig Emilie , Stöcklein Sophia , Kirsch Valerie 
Published: October 2022

AbstractKnowledge of the physiological endolymphatic space (ELS) is necessary to estimate endolymphatic hydrops (ELH) in patients with vestibulocochlear syndromes. Therefore, the current study investigated age-dependent changes in the ELS of participants with normal vestibulocochlear testing. Sixty-four ears of 32 participants with normal vestibulocochlear testing aged between 21 and 75 years (45.8 ± 17.2 years, 20 females, 30 right-handed, two left-handed) were examined by intravenous delayed gadolinium-enhanced magnetic resonance imaging of the inner ear (iMRI). Clinical diagnostics included neuro-otological assessment, video-oculography during caloric stimulation, and head-impulse test. iMRI data analysis provided semi-quantitative visual grading and automatic algorithmic quantitative segmentation of ELS volume (3D, mm3) using a deep learning-based segmentation of the inner ear’s total fluid space (TFS) and volumetric local thresholding, as described earlier. As a result, following a 4-point ordinal scale, a mild ELH (grade 1) was found in 21/64 (32.8%) ears uni- or bilaterally in either cochlear, vestibulum, or both. Age and ELS were found to be positively correlated for the inner ear (r(64) = 0.33, p < 0.01), and vestibulum (r(64) = 0.25, p < 0.05). For the cochlea, the values correlated positively without reaching significance (r(64) = 0.21). In conclusion, age-dependent increases of the ELS should be considered when evaluating potential ELH in single subjects and statistical group comparisons.
Teleneuropsychology: normative data for the assessment of memory in online settings
Authors: Rizzi Ezia , Vezzoli Michela , Pegoraro Sara , Facchin Alessio , Strina Veronica , Daini Roberta 
Published: October 2022

Abstract
Introduction
The COVID-19 pandemic has forced significant changes in clinical practice. Psychologists and neuropsychologists had to modify their settings to assess patients’ abilities, switching from an in-person modality to a remote setting by using video calling platforms. Consequently, this change brought about the need for new normative data tailored to remote settings.

Aim and methods
The study aimed to develop normative data for the online assessment of neuropsychological memory tests and to compare it with the published norms obtained in standard settings. Two hundred and four healthy Italian volunteers performed three verbal memory tests through the Google Meet platform: the Digit Span (Backward and Forward), the Rey Auditory Verbal Learning, and the Verbal Paired Associated Learning Test.

Results
This research provides specific norms that consider the influence of demographic characteristics. Their comparison with published norms shows a medium to high agreement between systems. The present study provides a reference for the clinical use of neuropsychological instruments to assess verbal memory in a remote setting and offers specific recommendations.
First-line disease modifying treatments in pediatric-onset multiple sclerosis in Greece: therapy initiation at more advanced age is the main cause of treatment failure, in a retrospective observational study, with a cohort from a single Multiple Sclerosis Center
Authors: Skarlis Charalampos , Markoglou Nikolaos , Gontika Maria , Bougea Anastasia , Katsavos Serafeim , Artemiadis Artemios , Chrousos George , Dalakas Marinos , Stefanis Leonidas , Anagnostouli Maria 
Published: October 2022

Abstract

Objectives
Long-term immunomodulatory therapy of pediatric onset-multiple sclerosis (POMS) is based mainly on published case series and internationally agreed guidelines. Relevant studies in the Greek population are absent from the literature. The purpose of this study is to present data on the efficacy and safety of the 1st line immunomodulatory drugs in the treatment of POMS patients.

Materials and methods
The present study included 27 patients meeting the IPMSSG criteria for POMS and who are monitored at the outpatient clinic of the Multiple Sclerosis and Demyelinating Diseases Unit (MSDDU), of the 1st Neurological Department, University Hospital of Aeginition. All patients received 1st line immunomodulatory drugs as initial therapy. Clinical, laboratory, and imaging parameters of the disease were recorded before and after treatment.

Results
Post-treatment, a significant reduction of the relapse number (mean ± SD: 2.0 ± 1.0 vs 1.2 ± 1.6, p = 0.002), EDSS progression (mean ± SD: 1.5 ± 0.8 vs 0.9 ± 0.7, p = 0.005) and ARR (mean ± SD: 1.5 ± 0.7 vs 0.4 ± 0.5, p = 0.0001) was observed, while no changes were observed in the EDSS score, (mean ± SD: 1.8 ± 0.6 vs 1.9. 0.6, p = 0.60). Advanced age at treatment initiation increased the risk for drug discontinuation before 24 months of therapy (HR = 0.6, 95% CI (0.35–0.99), p = 0.04).

Conclusions
Most pediatric patients are forced to switch to either more efficacious 1st line or 2nd line drugs. Additionally, our study suggests that older age at the time of the 1st line treatment initiation, contributes to earlier drug discontinuation.
Determination of specific lethal heat treatment parameters for pests associated with wood products using the Humble water bath
Authors: Noseworthy M. K. , Humble L. M. , Souque T. J. , John E. P. , Roberts J. , Lloyd C. R. , Allen E. A. 
Published: October 2022

AbstractHeat treatment is an effective sanitization method used for over half a century to reduce the risk of transporting pests associated with wood products. The determination of precise lethal heat treatment parameters for pests is critical for the development of globally harmonized plant protection regulatory treatment policies. Separation of heat treatment dose (time and temperature) from the factors associated with the method of heat application (delivery) and variables associated with wood characteristics allows for universal agreement on lethal dose and promotes efficient development of treatment schedule guidance. The Humble water bath is an effective and carefully calibrated heat treatment apparatus designed to test the effects of heat and determine lethal temperature doses. Specifications for building this apparatus and experimental treatment parameters are described. To demonstrate the capacities of the water bath apparatus, the effect of heat on a non-indigenous wood-boring beetle, Anisandrus dispar, is reported using heat-ramp schedules similar to industrial kiln heating applications. Adult A. dispar tested in vitro, did not survive 50 °C treatment temperature for 15 min time duration.
Online learning of variable ordering heuristics for constraint optimisation problems
Authors: Doolaard Floris , Yorke-Smith Neil 
Published: October 2022

AbstractSolvers for constraint optimisation problems exploit variable and value ordering heuristics. Numerous expert-designed heuristics exist, while recent research learns novel, customised heuristics from past problem instances. This article addresses unseen problems for which no historical data is available. We propose one-shot learning of customised, problem instance-specific heuristics. To do so, we introduce the concept of deep heuristics, a data-driven approach to learn extended versions of a given variable ordering heuristic online. First, for a problem instance, an initial online probing phase collects data, from which a deep heuristic function is learned. The learned heuristics can look ahead arbitrarily-many levels in the search tree instead of a ‘shallow’ localised lookahead of classical heuristics. A restart-based search strategy allows for multiple learned models to be acquired and exploited in the solver’s optimisation. We demonstrate deep variable ordering heuristics based on the smallest, anti first-fail, and maximum regret heuristics. Results on instances from the MiniZinc benchmark suite show that deep heuristics solve 20% more problem instances while improving on overall runtime for the Open Stacks and Evilshop benchmark problems.
Mutual Diffusivities of Binary Mixtures of Water and Poly(ethylene) Glycol from Heterodyne Dynamic Light Scattering
Authors: Wu Wenchang , Supper Malvina , Rausch Michael H. , Kaspereit Malte , Fröba Andreas P. 
Published: October 2022

AbstractIn the present study, the mutual diffusivity D11 in binary mixtures of water with technical polydisperse poly(ethylene) glycol (PEG) blends with molar masses of (1000, 4000, or 6000) g⋅mol−1 as well as with a purified monodisperse PEG homolog with a polymerization number of 21 and a molar mass of 943 g⋅mol−1 was investigated by heterodyne dynamic light scattering (DLS) as a function of temperature and/or PEG concentration. The measured D11 for technical PEG 1000 and pure PEG 943 match within the experimental uncertainties and agree well with the available literature data. D11 decreases with increasing molar mass of the PEGs at constant temperature and weight fraction. For the technical PEG 4000, it could be shown that D11 increases with increasing temperature and exhibits a nonlinear concentration dependence. This study demonstrates that heterodyne DLS can be applied for the reliable determination of D11 of aqueous solutions of PEGs over a broad range of PEG weight fractions from 0.01 up to the solubility limit with an average expanded uncertainty (k = 2) of 5.5 %. Moreover, the results show that monodisperse PEGs are suitable model systems for studying the diffusion behavior of bimodal and also multimodal particulate systems.
Improving growing substrates by adding the seaweed Cystoseira baccata
Authors: Rodríguez Maite Antelo , Illera-Vives Marta , Labrada Miguel Fernández , Labandeira Socorro Seoane , López-Mosquera María Elvira 
Published: October 2022

AbstractWe examined the impact of adding the seaweed Cystoseira baccata (Ochrophyta, Sargassaceae) in various forms to two different growing substrates: pine bark and gorse compost. Specifically, we examined the influence of the seaweed on the physical and chemical properties of the substrates, and on their agronomic performance on a lettuce crop. The seaweed was used in a 20% (v/v) proportion and three different forms, namely: fresh (FS), washed fresh (WFS), and washed and dried (WDS). The mixed substrates exhibited no signs of instability. FS and DWS increased the total water retention capacity of pine bark by 20% and 27%, respectively. Adding the seaweed in any of its three forms to this type of substrate, which is poor in nutrients and has a low electrical conductivity (EC), significantly increased its P, K, Mg and Na contents, as well as its EC (from 0.08 dS m–1 in the control substrate to 0.69, 0.12 and 0.27 dS m–1 in those containing FS, WFS and WDS, respectively). On the other hand, only in fresh form (FS) altered the salinity and total K content of a substrate rich in nutrients and salts such gorse compost (from 0.89 to 1.42 dS m−1 in terms of EC and 0.59% to 0.98% in K). All mixtures performed well as substrates for a lettuce crop. Those containing DWS increased aerial mass in gorse compost, while any of the tested formats increased aerial mass in pine bark.
Modeling and Flight Control of Small UAV with Active Morphing Wings
Authors: Emad Diaa , Mohamed Abdelfatah , Fanni Mohamed 
Published: October 2022

AbstractIn recent research works, morphing wings were studied as an interesting field for a small unmanned aerial vehicle (UAV). The previous studies either focused on selecting suitable material for the morphing wings or performing experimental tests on UAVs with morphing wings. Though, the dynamic modeling of active flexible morphing wings and their involved interactions with the aerodynamics of the UAV body are challenging subjects. Using such a model to control a small UAV to perform specific maneuvering is not investigated yet. The dynamic model of UAV with active morphing wings generates a multi-input multi-output (MIMO) system which rises the difficulty of the control system design. In this paper, the aeroelastic dynamic model of morphing wing activated by piezocomposite actuators is established using the finite element method and modal decomposition technique. Then, the dynamic model of the UAV is developed taking into consideration the coupling between the wing and piezocomposite actuators, as well as the dynamic properties of the morphing actuators with the aerodynamic wind disturbances. A model predictive control (MPC) is designed for the MIMO control system to perform specific flight maneuvering by tracking desired trajectories of UAV altitude and yaw angle. Additionally, the MPC achieves constrained behavior of pitch and roll angles to get satisfactory UAV motion. Also, the behaviors of the UAV control system using MPC are evaluated after adding Dryden wind turbulence to the UAV outputs. Finally, a UAV flight simulation is conducted which shows that the control system successfully rejects the applied disturbances and tracks the reference trajectories with acceptable behavior of pitch and roll angles.
Landed elites and education provision in England: evidence from school boards, 1871-99
Authors: Goñi Marc 
Published: October 2022

AbstractI study the relationship between land concentration and the expansion of state education in 19C England. Using a broad range of education measures for 40 counties and 1,387 School Boards, I show a negative association between land concentration and local taxation, school expenditure, and human capital. I estimate reduced-form effects of 19C land concentration, geographic factor endowments, and the land redistribution after the Norman conquest of 1066. The negative effects on state-education supply are stronger where rural labour can easily migrate, where landowners had political power, is not offset by voluntary schooling, and not driven by a demand channel. This suggests that landowners opposed taxation in order to reduce state education provision.
Extended Simples, Unextended Complexes
Authors: Calosi Claudio 
Published: October 2022

AbstractBoth extended simples and unextended complexes have been extensively discussed and widely used in metaphysics and philosophy of physics. However, the characterizations of such notions are not entirely satisfactory inasmuch as they rely on a mereological notion of extension that is too simplistic. According to such a mereological notion, being extended boils down to having a mereologically complex exact location. In this paper, I make a detailed plea to supplement this notion of extension with a different one that is phrased in terms of measure theory. This proposal has significant philosophical payoffs. I provide new characterizations of both extended simples and unextended complexes, that help re-evaluating the question of whether such entities are metaphysically possible. Finally, I advance several suggestions as to how different notions of extension relate, first, to one another and, second, to mereological structure.
Changes in survival over time for primary brain and other CNS tumors in the United States, 2004–2017
Authors: Cioffi Gino , Waite Kristin A. , Edelson Jacob L. , Kruchko Carol , Ostrom Quinn T. , Barnholtz-Sloan Jill S. 
Published: October 2022

Abstract
Purpose
Despite advances in cancer diagnosis and clinical care, survival for many primary brain and other central nervous system (CNS) tumors remain poor. This study performs a comprehensive survival analysis on these tumors.

Methods
Survival differences were determined utilizing the National Program of Cancer Registries Survival Analytic file for primary brain and CNS tumors. Overall survival and survival of the 5 most common histopathologies, within specific age groups, were determined. Overall survival was compared for three time periods: 2004–2007, 2008–2012, and 2013–2017. Survival differences were evaluated using Kaplan–Meier and multivariable Cox proportional hazards models. Models were adjusted for sex, race/ethnicity, and treatment. Malignant and non-malignant brain tumors were assessed separately.

Results
Among malignant brain and CNS tumor patients overall, there were notable differences in survival by time period among all age groups. Similar differences were noted in non-malignant brain and CNS tumor patients, except for adults (aged 40–64 years), where no survival changes were observed. Survival differences varied within specific histopathologies across age groups. There were improvements in survival in 2008–2012 and 2013–2017, when compared to 2004–2007, in children, AYA, and older adults with malignant tumors, and among older adults with non-malignant tumors.

Conclusion
Overall survival for malignant brain and other CNS tumors improved slightly in 2013–2017 for all age groups as compared to 2004–2007. Significant changes were observed for non-malignant brain and other CNS tumors among older adults. Information regarding survival over time can be utilized to identify population level effects of diagnostic and treatment improvements.
A reduced PAPR hybrid OFDM visible light communication system
Authors: Taha Basma , Fayed Heba A. , Aly Moustafa H. , Mahmoud Mohamed 
Published: October 2022

AbstractOrthogonal frequency division multiplexing (OFDM) is used by visible light communication (VLC) systems. Its main goal is to lessen inter-symbol interference's negative impacts. As a result, a lot of bandwidth and a high data rate are transmitted. Using OFDM-based VLC systems, nonetheless, have a high peak-to-average power ratio (PAPR). This research presents a new VLC system for indoor applications that reduces the PAPR while maintaining an acceptable bit error rate (BER). To achieve this, a hybrid pre-coding technique-based PAPR reduction solution is proposed; Vander-monde like matrix (VLM) combined with Gaussian matrix (GM). This technique takes advantage of both VLM and GM as a two stages for the signal to simultaneously reduce the PAPR and save the BER from damage. According to the results, the proposed solution (VLM in conjunction with GM) lowers the PAPR to 9.5 dB. Our system performs better when compared to other systems like discrete cosine transform (DCT), GM, VLM, DCT&GM, and original OFDM by 27%, 25%, 11%, 20%, and 34%, respectively.