bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males
Authors: Wilson Laura A. B. , Zajitschek Susanne R. K. , Lagisz Malgorzata , Mason Jeremy , Haselimashhadi Hamed , Nakagawa Shinichi 
Published: December 2022

AbstractSex differences in the lifetime risk and expression of disease are well-known. Preclinical research targeted at improving treatment, increasing health span, and reducing the financial burden of health care, has mostly been conducted on male animals and cells. The extent to which sex differences in phenotypic traits are explained by sex differences in body weight remains unclear. We quantify sex differences in the allometric relationship between trait value and body weight for 363 phenotypic traits in male and female mice, recorded in >2 million measurements from the International Mouse Phenotyping Consortium. We find sex differences in allometric parameters (slope, intercept, residual SD) are common (73% traits). Body weight differences do not explain all sex differences in trait values but scaling by weight may be useful for some traits. Our results show sex differences in phenotypic traits are trait-specific, promoting case-specific approaches to drug dosage scaled by body weight in mice.
Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
Authors: Kosa Peter , Barbour Christopher , Varosanec Mihael , Wichman Alison , Sandford Mary , Greenwood Mark , Bielekova Bibiana 
Published: December 2022

AbstractWhile autopsy studies identify many abnormalities in the central nervous system (CNS) of subjects dying with neurological diseases, without their quantification in living subjects across the lifespan, pathogenic processes cannot be differentiated from epiphenomena. Using machine learning (ML), we searched for likely pathogenic mechanisms of multiple sclerosis (MS). We aggregated cerebrospinal fluid (CSF) biomarkers from 1305 proteins, measured blindly in the training dataset of untreated MS patients (N = 129), into models that predict past and future speed of disability accumulation across all MS phenotypes. Healthy volunteers (N = 24) data differentiated natural aging and sex effects from MS-related mechanisms. Resulting models, validated (Rho 0.40-0.51, p < 0.0001) in an independent longitudinal cohort (N = 98), uncovered intra-individual molecular heterogeneity. While candidate pathogenic processes must be validated in successful clinical trials, measuring them in living people will enable screening drugs for desired pharmacodynamic effects. This will facilitate drug development making, it hopefully more efficient and successful.
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells
Authors: Li Qing , Zhang Liren , You Wenhua , Xu Jiali , Dai Jingjing , Hua Dongxu , Zhang Ruizhi , Yao Feifan , Zhou Suiqing , Huang Wei , Dai Yongjiu , Zhang Yu , Baheti Tasiken , Qian Xiaofeng , Pu Liyong , Xu Jing , Xia Yongxiang , Zhang Chuanyong , Tang Jinhai , Wang Xuehao 
Published: December 2022

AbstractProgrammed death receptor-1 (PD-1) blockade have achieved some efficacy but only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 ligand 1 (PD-L1) binds to its receptor PD1 on T cells to dampen antigen-tumor immune responses. However, the mechanisms underlying PD-L1 regulation are not fully elucidated. Herein, we identify that tumoral Prdm1 overexpression inhibits cell growth in immune-deficient mouse models. Further, tumoral Prdm1 overexpression upregulates PD-L1 levels, dampening anti-tumor immunity in vivo, and neutralizes the anti-tumor efficacy of Prdm1 overexpression in immune-competent mouse models. Mechanistically, PRDM1 enhances USP22 transcription, thus reducing SPI1 protein degradation through deubiquitination, which enhances PD-L1 transcription. Functionally, PD-1 mAb treatment reinforces the efficacy of Prdm1-overexpressing HCC immune-competent mouse models. Collectively, we demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion. Furthermore, PRDM1 overexpression combined with PD-(L)1 mAb treatment provides a therapeutic strategy for HCC treatment.
The dominant nature of Herzberg–Teller terms in the photophysical description of naphthalene compared to anthracene and tetracene
Authors: Manian Anjay , Russo Salvy P. 
Published: December 2022

AbstractThe first order and second order corrected photoluminescence quantum yields are computed and compared to experiment for naphthalene in this manuscript discussing negative results. Results for anthracene and tetracene are recalled from previous work (Manian et al. in J Chem Phys 155:054108, 2021), and the results for all three polyacenes are juxtaposed to each other. While at the Franck–Condon point, each of the three noted polyacenes were found to possess a quantum yield near unity. Following the consideration of Herzberg–Teller effects, quantum yields stabilised for anthracene and tetracene to 0.19 and 0.08, respectively. Conversely, the second order corrected quantum yield for naphthalene was found to be 0.91. Analysis of this result showed that while the predicted non-radiative pathways correlate well with what should be expected, the approximation used to calculate second order corrected fluorescence, which yielded very positive results for many other molecular systems, here is unable to account for strong second order contributions, resulting in a grossly overestimated rate of fluorescence. However, substitution of an experimental radiative rate results in a quantum yield of 0.33. This work extols the importance of Herzberg–Teller terms in photophysical descriptions of chromophores, and highlights those cases in which a treatment beyond the above approximation is required.
Automated analysis of fibrous cap in intravascular optical coherence tomography images of coronary arteries
Authors: Lee Juhwan , Pereira Gabriel T. R. , Gharaibeh Yazan , Kolluru Chaitanya , Zimin Vladislav N. , Dallan Luis A. P. , Kim Justin N. , Hoori Ammar , Al-Kindi Sadeer G. , Guagliumi Giulio , Bezerra Hiram G. , Wilson David L. 
Published: December 2022

AbstractThin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which provides an opportunity to assess plaque vulnerability. We developed an automated method that can detect lipidous plaque and assess fibrous cap thickness in IVOCT images. This study analyzed a total of 4360 IVOCT image frames of 77 lesions among 41 patients. Expert cardiologists manually labeled lipidous plaque based on established criteria. To improve segmentation performance, preprocessing included lumen segmentation, pixel-shifting, and noise filtering on the raw polar (r, θ) IVOCT images. We used the DeepLab-v3 plus deep learning model to classify lipidous plaque pixels. After lipid detection, we automatically detected the outer border of the fibrous cap using a special dynamic programming algorithm and assessed the cap thickness. Our method provided excellent discriminability of lipid plaque with a sensitivity of 85.8% and A-line Dice coefficient of 0.837. By comparing lipid angle measurements between two analysts following editing of our automated software, we found good agreement by Bland–Altman analysis (difference 6.7° ± 17°; mean ~ 196°). Our method accurately detected the fibrous cap from the detected lipid plaque. Automated analysis required a significant modification for only 5.5% frames. Furthermore, our method showed a good agreement of fibrous cap thickness between two analysts with Bland–Altman analysis (4.2 ± 14.6 µm; mean ~ 175 µm), indicating little bias between users and good reproducibility of the measurement. We developed a fully automated method for fibrous cap quantification in IVOCT images, resulting in good agreement with determinations by analysts. The method has great potential to enable highly automated, repeatable, and comprehensive evaluations of TCFAs.
Predictive modelling of Parkinson’s disease progression based on RNA-Sequence with densely connected deep recurrent neural networks
Authors: Ahmed Siraj , Komeili Majid , Park Jeongwon 
Published: December 2022

AbstractThe advent of recent high throughput sequencing technologies resulted in unexplored big data of genomics and transcriptomics that might help to answer various research questions in Parkinson’s disease (PD) progression. While the literature has revealed various predictive models that use longitudinal clinical data for disease progression, there is no predictive model based on RNA-Sequence data of PD patients. This study investigates how to predict the PD Progression for a patient’s next medical visit by capturing longitudinal temporal patterns in the RNA-Seq data. Data provided by Parkinson Progression Marker Initiative (PPMI) includes 423 PD patients without revealing any race, sex, or age information with a variable number of visits and 34,682 predictor variables for 4 years. We propose a predictive model based on deep Recurrent Neural Network (RNN) with the addition of dense connections and batch normalization into RNN layers. The results show that the proposed architecture can predict PD progression from high dimensional RNA-seq data with a Root Mean Square Error (RMSE) of 6.0 and a rank-order correlation of (r = 0.83,p < 0.0001) between the predicted and actual disease status of PD.
Ceramic-reinforced HEA matrix composites exhibiting an excellent combination of mechanical properties
Authors: Mehmood M. Adil , Shehzad Khurram , Mujahid M. , Yaqub Talha Bin , Godfrey Andy , Fernandes Filipe , Muhammad F. Z. , Yaqoob Khurram 
Published: December 2022

AbstractCoCrFeNi is a well-studied face centered cubic (fcc) high entropy alloy (HEA) that exhibits excellent ductility but only limited strength. The present study focusses on improving the strength-ductility balance of this HEA by addition of varying amounts of SiC using an arc melting route. Chromium present in the base HEA is found to result in decomposition of SiC during melting. Consequently, interaction of free carbon with chromium results in the in-situ formation of chromium carbide, while free silicon remains in solution in the base HEA and/or interacts with the constituent elements of the base HEA to form silicides. The changes in microstructural phases with increasing amount of SiC are found to follow the sequence: fcc → fcc + eutectic → fcc + chromium carbide platelets → fcc + chromium carbide platelets + silicides → fcc + chromium carbide platelets + silicides + graphite globules/flakes. In comparison to both conventional and high entropy alloys, the resulting composites were found to exhibit a very wide range of mechanical properties (yield strength from 277 MPa with more than 60% elongation to 2522 MPa with 6% elongation). Some of the developed high entropy composites showed an outstanding combination of mechanical properties (yield strength 1200 MPa with 37% elongation) and occupied previously unattainable regions in a yield strength versus elongation map. In addition to their significant elongation, the hardness and yield strength of the HEA composites are found to lie in the same range as those of bulk metallic glasses. It is therefore believed that development of high entropy composites can help in obtaining outstanding combinations of mechanical properties for advanced structural applications.
Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa
Authors: Ezinmegnon Sem , Mommert Marine , Bartolo Francois , Agbota Gino , Darius Sossou , Briand Valérie , d’Almeida Marceline , Alao Maroufou Jules , Dossou-Dagba Ida , Massougbodji Achille , Lausten-Thomsen Ulrik , Pachot Alexandre , Vachot Laurence , Yugueros-Marcos Javier , Brengel-Pesce Karen , Fievet Nadine , Tissieres Pierre 
Published: December 2022

AbstractFew biomarkers for sepsis diagnosis are commonly used in neonatal sepsis. While the role of host response is increasingly recognized in sepsis pathogenesis and prognosis, there is a need for evaluating new biomarkers targeting host response in regions where sepsis burden is high and medico-economic resources are scarce. The objective of the study is to evaluate diagnostic and prognostic accuracy of biomarkers of neonatal sepsis in Sub Saharan Africa. This prospective multicentre study included newborn infants delivered in the Abomey-Calavi region in South Benin and their follow-up from birth to 3 months of age. Accuracy of transcriptional (CD74, CX3CR1), proteic (PCT, IL-6, IL-10, IP-10) biomarkers and clinical characteristics to diagnose and prognose neonatal sepsis were measured. At delivery, cord blood from all consecutive newborns were sampled and analysed, and infants were followed for a 12 weeks’ period. Five hundred and eighty-one newborns were enrolled. One hundred and seventy-two newborns developed neonatal sepsis (29.6%) and death occurred in forty-nine infants (8.4%). Although PCT, IL-6 and IP-10 levels were independently associated with sepsis diagnosis, diagnostic accuracy of clinical variables combinations was similar to combinations with biomarkers and superior to biomarkers alone. Nonetheless, CD74, being the only biomarkers independently associated with mortality, showed elevated prognosis accuracy (AUC > 0.9) either alone or in combination with other biomarkers (eg. CD74/IP-10) or clinical criterion (eg. Apgar 1, birth weight). These results suggest that cord blood PCT had a low accuracy for diagnosing early onset neonatal sepsis in Sub Saharan African neonates, while association of clinical criterion showed to be more accurate than any biomarkers taken independently. At birth, CD74, either associated with IP-10 or clinical criterion, had the best accuracy in prognosing sepsis mortality.Trial registration Clinicaltrial.gov registration number: NCT03780712. Registered 19 December 2018. Retrospectively registered.
Image encryption based on fractional discrete cosine transform and DWT with interplane arrangements in dost domain
Authors: Sundaram Gaurav , Panna Bhaskar , Jha Rajib Kumar , Kumar Sumit 
Published: December 2022

AbstractIn this paper, a novel color image encryption scheme based on fractional discrete cosine transform (FrDCT) and discrete wavelet transform (DWT) with interplane arrangements in the discrete orthonormal Stockwell transform (DOST) domain is presented. Color images are encrypted using the keys of FrDCT and coefficients of interplane arrangement of DWT sub‐bands. These keys are applied on three independent planes, that is, R, G, and B. To ensure the correct decryption of the encrypted image, every key need to be clearly understood in the correct sequence and its exact values. FrDCT has the advantageous feature of storing real‐valued coefficients, and the energy of the image can be represented with very few coefficients. Therefore, transmitting and storing the encrypted image becomes easy. FrDCT may be considered a real‐valued cosine version of fractional Fourier transform (FrFT), which is used successfully for storage and transmission due to its property of compacting energy distribution. Furthermore, for more robustness, interplane arrangements are explored. The concept of interplane arrangements has not been substantially reported in the existing literature. The comparison of the technique with other similar encryption techniques available in the literature has been carried out by performing different experiments to examine the efficacy of the proposed method. It is found that the proposed method outperforms other existing techniques.
Strukturierendes Vorgehen in der Balintgruppe – Perspektiven
unter Online-Bedingungen
Authors: Gesmann Mechthild 
Published: December 2022

ZusammenfassungIn der Durchführung einer Balintgruppe unter Online-Bedingungen scheint
eine Anpassung der Vorgehensweise für den Gruppenprozess erforderlich zu
sein. Ein vertrauensbildender Anfangskontakt fördert die Kommunikation
zwischen den Teilnehmenden und der Gruppenleitung. Die Strukturierung der
Fallbesprechung ermöglicht eine wertschätzende und lebendige
Gruppeninteraktion. Ziele der Balintgruppenarbeit in den Bereichen Empathie,
Toleranz und Verständnis können auch im Online-Setting erreicht
werden.
Far-Lateral Approach for Foramen Magnum Meningioma: An Anatomical Study with Special Reference to Bulbopontine Junction
Authors: Beucler Nathan , Haikal Christelle , Sellier Aurore , May Adrien , Meyer Mikael , Fuentes Stéphane 
Published: December 2022

AbstractIntracranial meningiomas are sometimes located anteriorly to the foramen magnum and can cause disabling long tract symptoms. The far-lateral approach has been developed to provide an extensive view over the bulbopontine junction and the surrounding lower cranial nerves and upper spinal nerves with a good control on the vertebral artery, allowing the safe resection of such tumors. It is the report of a case with anatomical study before and after the removal of the meningioma. The use of the far-lateral approach allowed us to (1) control the vertebral artery in its V3 (Atlantic extradural) and V4 (intradural) portion (2) have an optimal visibility on the lower cranial nerves, the upper spinal nerves, and the bulbopontine junction, and (3) perform a Simpson 2 resection of the tumor that was inserted between the lower clivus and the upper odontoid process. Beyond its interest for the safe resection of tumors located anteriorly to the foramen magnum, the far-lateral approach is of particular anatomical interest. It allowed us to review the anatomy of the craniocervical junction.
A multi-layered comparative analysis of English-medium instruction in the Netherlands
Authors: van der Hoeven Dymphi , Duarte Joana 
Published: December 2022

AbstractThe rise of English in Dutch higher education has been accompanied by a language ideological debate that affects students’ and lecturers’ lives at the micro level, policy and planning at the meso (institutional) level and is related to the macro perspective (national political agenda). This study explores how language ideologies and attitudes play a role in this debate by comparing lecturers’ perceptions of the use of English in higher education to general language ideologies reflected in the Dutch printed press. A thematic analysis was conducted, including a three-dimensional investigation incorporating a vertical approach (macro, meso, micro) combined with a horizontal approach focusing on ideological themes present at the vertical level. Our data consist of 151 news items and 20 interviews with lecturers in higher education. Results show that monolingual language ideologies are the norm in both the perceptions of teaching staff and the Dutch media. Lecturers were generally more positive towards the exclusive use of English than the printed media. The study suggests that the Dutch/English dichotomy and accompanying persistence of a monolingual language ideology contrast with the reality of the Netherlands as a multilingual community. Implications for language policy and practice within EMI are presented.
Copper alumina reinforced poly(aniline-co-indole) nanocomposites for optoelectronic devices
Authors: Sankar S. , Furhan  , George Ajith , Ramesan M. T. 
Published: December 2022

Copper alumina (Cu-Al2O3) reinforced poly(aniline- co-indole) (PANI- co-PIN) nanocomposites were prepared and characterised by UV-vis spectroscopy, FE-SEM and DSC. The bandgap energy decreased with the addition of Cu-Al2O3 to PANI- co-PIN. The FE-SEM confirms the uniform dispersion of nanoparticles in the copolymer. The DSC showed a shift in glass transition temperatures to higher regions with Cu-Al2O3 concentrations. The frequency-temperature-dependent dielectric parameters and electrical conductivity of nanocomposites were investigated. Activation energy calculated from Arrhenius equation decreases with increasing frequency. The real and imaginary part of electric modulus implies the thermally activated dielectric relaxations. The decreasing radius of semicircles in Nyquist plot with increasing temperatures indicates the existence of thermally activated conduction mechanisms. Different theoretical models were used to predict the DC conductivity mechanism in copolymer nanocomposites.
The FMRFamide-like peptide FLP-1 modulates larval development by regulating the production and secretion of the insulin-like peptide DAF-28 in Caenorhabditis elegans
Authors: Une Risako , Kageyama Natsumi , Ono Masahiro , Matsunaga Yohei , Iwasaki Takashi , Kawano Tsuyoshi 
Published: December 2022

ABSTRACT
The FMRFamide-like peptides (FLPs) are conserved in both free-living and parasitic nematodes. This molecular genetic study verified the relevance of the flp-1 gene, which is conserved in many nematode species, to the larval development of the free-living soil nematode Caenorhabditis elegans. Using C. elegans as a model, we found that: (1) FLP-1 suppressed larval development, resulting in diapause; (2) the secretion of FLP-1, which is produced in AVK head neurons, was suppressed by the presence of food (Escherichia coli) as an environmental factor to continue larval development; (3) the FLP-1 reduced the production and secretion of DAF-28, which is produced in ASI head neurons and is the predominant insulin-like peptide (INS) present. FLP-1 is conserved in many species of plant–parasitic root-knot nematodes that cause severe damage to crops. Therefore, our findings may provide insight into the development of new nematicides that can disturb their infection and development.
Validity and Reliability of the Arabic Version of the Short Form Social Well-Being Scale
Authors: Albrithen Abdulaziz 
Published: December 2022

Abstract
There has been growing interest in and calls for wellness and well-being among the population. Scientific research has expanded the study of social well-being and its positive impact on human life since half-century. This study explores the measurement of social well-being within the context of global attempts to adapt codified measures of this concept. International studies have proven that the Social Well-Being Scale (SWBS) is an acceptable measure and has a high level of validity and reliability. This study adapts the short form of the SWBS to Arabic culture using a sample of Emiratis (N = 328). The results show that this scale is useful and accurate for assessing social well-being in Arab culture.