bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Observational Study to Evaluate Causality, Preventability
and Severity of Adverse Drug Reaction Associated with Anticancer Drugs
in a Tertiary Care Hospital in Northern India
Authors: Sidhu Shabir , Thakur Ravi , Bajaj Jagminder Kaur , Dutta Archana 
Published: February 2022

Background:
Chemotherapy has high efficacy, but it is associated with several adverse
drug reactions (ADRs).

Objectives:
A retrospective observational study to explore the prevalence, causality, and preventability
of ADRs of anticancer agents was conducted.

Methods:
The study was carried out at Punjab Institute of Medical Sciences Jalandhar, Punjab after
obtaining IEC approval. The data was collected from cancer patients undergoing treatment at the
hospital. The causality assessment of the collected data was done by using WHO causality assessment
criteria. The preventability and severity of the reported ADRs were also assessed.

Results:
From 50 medical records, a total of 47 ADRs were recorded among 25 patients, out of
which 16 were females and the rest were males. The cancer cases observed were breast carcinoma,
leukaemia, lung, colon, and ovarian cancer. The highest number of ADRs were observed with alkylating
agents, followed by taxanes, antimetabolites, kinase inhibitors, and monoclonal antibodies.
The most affected organ systems were the gastrointestinal system, blood, and lymphatic system.
According to the causality assessment, the majority of the ADRs were of the "possible" category.
Preventability analysis showed that 85.11% of ADRs were unavoidable reactions, while
14.89% of ADRs were possibly avoidable. Severity analysis of ADRs showed that 87.23% of
ADRs were mild and 12.77% were of moderate severity. The majority of the ADRs were unavoidable
and mild to moderate in severity.

Conclusion:
Since the majority of the ADRs were of the unavoidable category, it indicates that the
treatment regimens are acceptable as per the current clinical management of cancer patients.
Etiology and Antimicrobial Resistance Profile of Superficial Pyogenic
Infections from a Tertiary Care Hospital, Western Rajasthan, India
Authors: Nag Vijaya Lakshmi , Kombade Sarika P. , kaur Navneet , Singh Shambhavi 
Published: February 2022

Background:
Superficial pyogenic infection (SPI) is the type of a pyogenic infection, which
involves the infections of the skin, subcutaneous tissue, and soft tissue. These infections can cause
significant morbidity. Antimicrobial resistance (AMR) has emerged due to the rampant use of broadspectrum
agents in superficial pyogenic infections.

Objective:
The aim of the study was to identify the microbial profile of superficial pyogenic infections
and study their antimicrobial resistance.

Methods:
A cross-sectional observational study was carried out at the Department of Microbiology of
a tertiary care hospital in the western region of Rajasthan. Samples included pus, aspirate from the
abscess, necrotic tissue, and post-surgical drainage from infected skin at different sites of the patients
attending OPD or admitted in IPD and ICU of the hospital. Identification of isolates was carried out by
standard bacteriological techniques. The antibiotic susceptibility testing (AST) of bacterial isolates was
done by Kirby Bauer disk diffusion method on Mueller Hinton agar (HiMedia, India), and in a few
cases, by automated Microscan system as recommended by the Clinical and Laboratory Standards
Institute (CLSI), Wayne, USA.

Result:
A total of 2283 various specimens were obtained from different areas of healthcare facilities.
Pathogenic bacterial isolates were recovered from 303 specimens. Staphylococcus aureus and
Escherichia coli were found to be the main offenders. The effective antibiotics for gram-positive isolates
were clindamycin, cotrimoxazole, linezolid, tetracycline, and vancomycin, and for gram-negative
bacteria, meropenem, imipenem and amikacin were seen to be effective.

Conclusion:
This study can help formulate a local antibiotic policy which will restrict the unsupervised
antibiotic use and strengthen antibiotic stewardship practices in the hospitals.
Numerical and physical modeling of wind loads on long-span shell structures
Authors: Lampsi Boris B. , Shilov Sergey S. , Khazov Pavel A. 
Published: February 2022

Introduction. Wind load has a significant impact on buildings and structures. It triggers the evolution of the stress-strain state that causes various kinds of deformations. Requirements, applicable to the serviceability limit state, are important for the construction of long-span structures. In some cases, the analysis of the distribution of wind effects over the surface of a construction facility may be a challenging task. The purpose of the study is to identify the pattern of the wind load distribution over the shell of a long-span structure using physical and numerical methods, compare and analyze the obtained results.
Materials and methods. In the course of the study, a model of the shell structure was tested in the wind tunnel in the course of the physical testing. The model was made of polymer materials using the 3D printing technology. In addition, the article addresses the procedure for conducting full-scale tests in a wind tunnel. Numerical modeling was performed using various software and numerical software packages, such as Ansys CFX, SOLIDWORKS.
Results. The article presents the results of physical tests conducted in a wind tunnel, demonstrates the tables that have the values of aerodynamic coefficients and wind pressures, on the basis of which colour pressure isofields are made. Also, the article presents the results of iterative calculations of numerical models made using various software and numerical software packages. In addition, wind flow distributions were analyzed, since the object of the study has such a characteristic feature as an open-air shell, which allows the air flow to reach the structure from below.
Conclusions. The authors analyzed the data obtained as a result of the research; the convergence between the results of physical tests and numerical modeling in Ansys CFX was identified, a great discrepancy between numerical and physical studies was identified as a result of the application of other software packages. When designing buildings and structures, having intricate geometric shape, both physical and numerical modeling should be conducted.
B-spline wavelet discrete-continual finite element method for the local solution to the two-dimensional problem of the theory of elasticity
Authors: Akimov Pavel A. , Mozgaleva Marina L. 
Published: February 2022

Introduction. The distinctive article presents a local semi-analytical solution to the problem of the two-dimensional theory of elasticity. The corresponding structures, featuring the regularity (constancy) of physical and geometric parameters (the modulus of elasticity of the material of the structure, the Poisson’s ratio of the material of the structure, dimensions of the cross section of the structure) along one direction (dimension) are under consideration. This direction is conventionally called the basic direction.
Materials and methods. The B-spline wavelet discrete-continual finite element method (DCFEM) is used. The initial ope­rational formulation of the problem was constructed using the theory of distribution and the so-called method of extended domain, proposed by Prof. Alexander B. Zolotov.
Results. Some topical issues of construction of normalized basis functions of a B-spline are considered, the approximation technique for corresponding vector functions and operators within DCFEM is described. Along the basic direction, the problem remains continual and an exact analytical solution can be obtained, while along the non-basic direction the finite element approximation is used in combination with a wavelet analysis apparatus. As a result, we can obtain a discrete-continual formulation of the problem. Thus, we have a multi-point (in particular, a two-point) boundary problem for the first-order system of ordinary differential equations with constant coefficients. A special correct analytical method for the solution of such problems was developed, described and verified in numerous papers written by the authors. In particular, we consider the simplest sample analysis of a deep beam, fixed along the side faces and subjected to the load concentrated in the centre of the structure.
Conclusions. The solution to the verification problem obtained using the proposed version of the wavelet-based DCFEM was in good agreement with the solution obtained using a conventional finite element method (corresponding solutions were constructed with localization and without localization; these solutions coincide almost completely, while the advantages of the numerical-analytical approach are quite obvious). It is shown that the use of B-splines of various degrees within the wavelet-based DCFEM leads to a significant reduction in the number of unknowns.
Changes in the initial parameters of waves caused by distortions in the scale of a hydraulic model
Authors: Shelushinin Yuriy A. 
Published: February 2022

Introduction. The distorted scale method is often used to develop physical models of hydraulic structures. Notably, scientific researches concerning the methodology of distortions are quite rare, especially those that are focused on the modeling of wind waves. In the modern practice, scale distortions only affect the underwater topography and hydraulic structures. In this case, initial waves remain unchanged, and this can lead to errors in the wave mode at the control points of a model. Given the data on errors, the author considers the changes in the parameters of initial waves, if the scale of a physical model is distorted.
Materials and methods. The author used methods of physical and numerical modeling. Experimental studies were conducted in a wave flume and a wave pool that had a wavemaker. In the course of the experiments, the initial wave mode was changed and the parameters of waves were measured at the control points of distorted physical models. Numerical mode­ling was employed to analyze the computational patterns similar to the physical models.
Results. The author used physical models featuring varying degrees of distortion to obtain a collection of the wave mode data under the conditions of the wave transformation and diffraction. Physical and numerical modeling results are compared. The author provides an assessment of the results attained by changing the parameters of initial waves and distorted physical models.
Conclusions. The scale distortion triggers changes in the wave mode that may not be easy to control and correct. This fact must be taken into account when distorted hydraulic models are developed. This approach demonstrates varying efficiency if applied to different physical models featuring characteristic processes.
Justification of the optimal base choice for the anti-filtration circuit during the reclamation of toxic waste storage facilities
Authors: Solsky Stanislav V. , Kotlov Oleg N. , Sobkalov Fedor P. 
Published: February 2022

Introduction. Storage facilities, designated for the toxic production waste and located on the premises of the former Sredne-Volzhsky chemical plant in Chapayevsk, Samara Region, are sources of negative environmental impacts. The situation is aggravated by the lack of a reliable seepage prevention circuit at toxic waste storage facilities, enclosed by natural impermeable layers. The purpose of the study is to substantiate the choice of the optimal base for seepage prevention curtains along the perimeter of toxic waste storage facilities by clarifying the filtration characteristics of impervious soils using the interpretation of special experimental filtration works, followed by the testing of the effectiveness of engineering solutions using the developed geological filtration model.
Materials and methods. Processing Modflow is the software designed for the 3D filtration and pollutant transport modeling. The input data for a geological filtration model included technical reports on engineering surveys conducted in 2013 on the premises of the former Sredne-Volzhsky chemical plant, as well as the results of special experimental and filtration works and plant site level observations interpreted using the ANSDIMAT software.
Results. The filtration characteristics of the clay rocks of Upper Quaternary deposits were clarified as a result of the interpretation of special experimental and filtration works by the ANSDIMAT software through graphic analytical methods, and the application of a numerical model by the Processing Modflow software to imitate these works. The resulting characteristics confirmed the usability of this engineering geological element as the base for the designed anti-seepage curtains. The Processing Modflow software was applied to confirm the high efficiency of the filtration prevention circuit, which allowed to significantly reduce inflows in toxic waste storage facilities in the course of their reclamation.
Conclusions. In the process of reclamation of the area, occupied by the former Sredne-Volzhsky chemical plant, the option, recommended for implementation, is the installation of anti-seepage curtains around the perimeter of the toxic waste storage facilities for the circuit to be enclosed by the clay rock of the Upper Quaternary deposits. The proposed engineering solution will allow the highly toxic filtrate to be concentrated inside the toxic waste storage facilities to prevent its penetration into the environment.
Ekte eller falsk? Kampen om vaniljesmaken og merking av industrielt produsert mat
Authors: Stokland Håkon B. 
Published: February 2022

This article shows how cultural constructions of food can have a relatively direct impact on food policy, and thus form an important part of the mediation processes associated with the integration of new, synthetic products into our food systems. Since 2010, food product labeling in Norway has received far greater attention than before – from politicians, the regulatory authorities, manufacturers, consumer organizations and consumers. The regulation and practical handling of labeling has also become considerably more stringent. The article argues that this trend should be seen in the context of changes in the cultural understandings of “authentic” and “fake” food in the preceding decade.
During the 2000s, many Norwegians gained a new understanding of vanilla. The previously appreciated vanilla flavor we knew from vanilla sugar, vanilla ice cream and vanilla sauce was revealed to be from industrially produced, artificial vanillin. Not only did this substance have no connection to the vanilla orchid, from which real vanilla derives, vanillin was to a great extent produced from the by-products of the paper industry and crude oil. These new understandings – or cultural constructions – can be seen in the context of an evolving international critique of modern and industrial food production. In this discourse, industrialized food products are construed as unnatural and false if presented as “ordinary” food. This article examines how new understandings of vanilla flavoring emerged and increased in importance and scope in Norway in the period after the year 2000. Furthermore, it argues that these cultural constructions were decisive in making the regulation and practice of food labeling stricter and subject to greater scrutiny in the following decade.
Conversaciones no patrimoniales para desordenar el futuro
Authors: Barbieri Ariel , Serrano Javier 
Published: February 2022

El artículo que aquí se presenta es el resultado de conversaciones digitales entre un antropólogo y un semiólogo en tiempos de pandemia, condiciones de producción inéditas por la relación que puede existir con el tema mismo de este artículo ya que, en este contexto de barbijos y aislamiento, se renueva el vínculo entre la herencia y el futuro de la humanidad.
En este sentido, las preguntas que surgen en este intercambio son apenas intentos para establecer algunos criterios con los cuales situar un discurso sobre el patrimonio que, a partir de considerar los alcances conceptuales de la imaginación y su práctica, logre desandar el camino que cierta cronología occidental había establecido para, de esta manera, abrir otras cosmovisiones, posibilidades no patrimoniales y nuevos modos de hacer el tiempo, la historia y la memoria. Operaciones estéticas de nuevas ciudadanías que entienden que el futuro puede no tener un horizonte tan preciso.
Alodoxia afectiva. Una política de las emociones en el neoliberalismo
Authors: Sánchez Ceci Pablo Daniel 
Published: February 2022

El tema de este trabajo es la producción de políticas culturales de las emociones en el neoliberalismo reciente, es decir el vínculo entre afectos y políticas expresado en materialidades discursivas. Nuestro objetivo es presentar un primer análisis que articula categorías del análisis del discurso, el giro afectivo y la filosofía política posfundamento, a partir de una serie de discursos como una muestra parcial de cómo se configuran algunas emociones como legítimas y otras no.
El ensayo que sigue está dividido en cuatro secciones. En la primera presentaremos un corpus de discursos del ex-presidente Mauricio Macri en distintos momentos de su trayectoria política para identificar la configuración de la dimensión afectiva. En el segundo apartado recuperaremos el análisis del discurso de Macri en términos del neoliberalismo como lengua afectiva y como promesa/amenaza a partir de los desarrollos de Dahbar y Levstein (2020). En el tercer apartado, recuperaremos las consideraciones de Martínez (2020) sobre «la autonomía como ideal moral y estigmatización de la demanda» como organizadoras de una cierta economía afectiva resultante de los vínculos entre precarización y neoliberalismo. Finalmente, proponemos la noción de alodoxia afectiva a partir de desarrollar la interpretación que Ahmed (2019) realiza de «La distinción» de Bourdieu.
En primera persona
Authors: Ortega Mariana 
Published: February 2022

La FM Comunitaria La Voz Indígena es una radio pluriétnica, integrada por comunicadores de los pueblos wichi, guaraní, toba qom y chorote. Esta experiencia, ubicada en Tartagal (norte de la provincia de Salta) da cuenta de las complejas relaciones que los pueblos originarios entablan con el Estado.
La emergencia de la comunicación comunitaria e indígena significó una profunda transformación en la vida de este colectivo. Construida para revertir la exclusión de las voces indígenas de los medios de comunicación locales, esta emisora logró configurar un espacio de representación propia, no solo para transformar estigmas sino fundamentalmente para afirmar la existencia indígena en el presente.
La sanción de la Ley de Servicios de Comunicación Audiovisual y el reconocimiento del derecho a la comunicación indígena, movilizó sentidos que nos instan a repensar la relación entre el Estado, la promoción de derechos y las resistencias indígenas.
En este artículo proponemos detener el foco en la interacción entre la comunicación indígena y el derecho a la comunicación, a partir del concepto “ciudadanías comunicacionales”. Consideramos que el análisis de los efectos del reconocimiento de derechos en la vida contemporánea de los pueblos originarios, arroja perspectivas importantes para reflexionar sobre los movimientos indígenas y sus reivindicaciones de autonomía.
ciudad que resiste
Authors: Di Meglio Juan 
Published: February 2022

El presento texto es una reseña del libro “La Ciudad que Resiste. Hacia un urbanismo feminista” (Editorial de la Universidad de La Plata, 2019) escrito de manera colectiva por las distintas colectivas vinculadas a las experiencias que se relevan en el trabajo.
El libro, a partir de recuperar distintas experiencias organizativas e intervenciones, busca relevar distintas prácticas de activismo urbano bajo el protagonismo de colectivas que, bajo el paraguas teórico, filosófico y hasta ético del urbanismo feminista, buscan interpelar los modos en los que se expresa y se condensa en el espacio el patriarcado y las relaciones opresivas que de él se desprenden.
Reseña sobre “Crisis económicas argentinas de Mitre a Macri” de Julián Zícari
Authors: González Pratx Evangelina Belén 
Published: February 2022

Este es un libro que nace a través de la certeza sobre las crisis económicas ocurridas en nuestro país: podemos pensarlas, por un lado, comprendiéndolas para evitarlas, o por el otro, estaremos en un círculo sin acabar y repetir.
Este libro que estudia entre 1820 al 2020 Argentina sufrió 16 crisis económicas. Ante ojos numéricos realmente es estremecedor cómo Argentina puede seguir en un círculo sin salida de crisis tras crisis y no poder encontrar una solución en cada provincia, país, continente y el mundo. Toda crisis repercute en otra y así sucesivamente.
En su libro comienza con una introducción donde propone el concepto de crisis como tapete, relacionándolo con el concepto de economía. Propone un recorrido sobre los tres modelos económicos y una posible solución. Busca hacer un abordaje sobre la totalidad de las crisis económicas argentinas desde la unión nacional hasta la actualidad. Es por esto, que Zícari (2020) propone realizar un análisis, primero, del Modelo Agro-exportador (MAE), y un recorrido por las 6 (seis) crisis argentinas: 1866, 1873, 1885, 1890, 1913 y 1930. Segundo, aborda la Industrialización por Sustitución de Importaciones (ISI), su funcionalidad y las 4 (cuatro) crisis que pasó: 1951/52, 1959, 1962/63 y 1975. En tercer lugar, analiza las 6 (seis) crisis más contemporánea, relacionadas con la Valorización Financiera (VAFI) y con el neoliberalismo: 1981/82, 1989, 1995, 2001, 2008 y 2018/19). En cuarto lugar, busca desplegar una mirada global sobre las caracterizaciones propuestas, realizando un análisis comparativo sobre las crisis argentinas y sus correspondientes explicaciones. Por último, realiza una serie de conclusiones, donde la idea central sobre la crisis es que es un dispositivo de poder.
La lectura y la comprensión de la historia, este libro propone estudiar y vislumbrar estas crisis, averiguando, indagando e investigando elementos que permitan evitarlas en el futuro. El autor repasa y analiza los componentes que tienen en común cada crisis, los desiguales, las ventajas y desventajas y traza tipologías donde se debaten diversos modelos explicativos, pero no aplicables en un momento de la crisis o una que pueda ocurrir para poder evitarla. Allí es donde señala los puntos de vulnerabilidad que condujeron a los distintos daños, conflictos y problemáticas financieras y económicas del país en nuestra historia reciente.
Zícari (2000) complementa sus estudios con investigaciones interdisciplinarias que tiene en cuenta a actores sociopolitólogos/as, socioantropólogos/as, historiadores/as, comunicadores/as, economistas, entre otros/as, que hibridan el tema para congeniar este recorrido valioso. De esta manera, sigue siendo un procedimiento y un proceso integral, sistemático y exhaustivo para seguir (re)construyendo el sistema económico y social argentino.
Pathology in Practice
Authors: Cleymaet Allison M. , de Linde Henriksen Michala , Pederson Samantha L. , Sadar Miranda J. , Johnston Matthew , Tovar-Lopez Gretel , Daniels Joshua , Sharkey Leslie , Teixeira Leandro B. C. 
Published: February 2022

Abstract
In collaboration with the American College of Veterinary Pathologists