bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lycorine impedes 7,12-dimethylbenz(a)anthracene exposed hamster oral carcinogenesis through P13K/Akt and NF-κB inhibition
Authors: Gan Yi , He Ai’e , Zhu Lilei , Yao Yao , Lv Chunhua 
Published: June 2022

Abstract

Objectives
Oncogenic signaling pathways that are activated abnormally play a key activity in tumor initiation and development. This research aimed to examine the preventive efficiency of lycorine in the buccal pouch hamster tumor model based on its capacity to target phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor-kappa B (NF-κB) signaling cascades.

Methods
The induction of oral tumor in male golden Syrian hamsters was done by 7,12-dimethylbenz [a] anthracene (DMBA) painting on the left buccal pouch thrice a week for 10 weeks. The chemopreventive effect of lycorine (20 mg/kg b.w.) was assessed by treating orally for 14 weeks of the experimental period. The biochemical endpoints such as lipid peroxidation (LPO), antioxidants, and phase I and II detoxification agents were analyzed.

Results
The treatment of lycorine to DMBA-induced hamsters drastically suppressed tumor incidence and tumor size and reverted the levels of the biochemical indicator. Moreover, lycorine significantly downregulated the p53, Cyclooxygenase 2 (cox-2), and P13K/Akt signaling and inhibited the phosphorylation of NF-κB and nuclear factor-kappa-B-inhibitor alpha (Iκ-Bα) in DMBA-induced hamsters.

Conclusions
The oral administration of lycorine effectively inhibited tumor cell proliferation, restored the antioxidant, LPO, and detoxification enzymes, and inhibited NF-κB signaling in oral tumorigenesis. Thus, the use of lycorine after a proper clinical trial could be effective for oral tumorigenesis treatment.
Radioiodine remnant ablation in stage I adult papillary thyroid carcinoma: does it improve postoperative outcome?
Authors: Hay Ian D , Kaggal Suneetha , Thompson Geoffrey B 
Published: June 2022

Objective
To determine whether radioiodine remnant ablation (RRA) reduces cause-specific mortality (CSM) or tumor recurrence rates (TRR) after potentially curative bilateral thyroidectomy (BT) in low-risk adult papillary thyroid carcinoma (APTC) patients, we compared postoperative outcomes in 1836 pTNM stage I APTC patients having BT alone with 832 having BT+RRA during two consecutive 25-year periods.

Methods
The THEN cohort (consecutively managed during 1966–1990) comprised 809 patients (36% having BT+RRA) and the NOW cohort (1991–2015) comprised 1859 patients (29% BT+RRA). Analyses of differences in occurrence rates between BT alone and BT+RRA patients were performed with SAS software.

Results
During 1966–1990, when RRA rates rose ten-fold, 20-year CSM after BT alone was 0.6% and after BT+RRA was 1.2% (P = 0.66); during 1991–2015, when RRA rates progressively fell, no PTC deaths occurred in 1859 patients. In the THEN cohort, RRA did not significantly improve TRR at local, regional, or distant sites (P > 0.1), when compared to BT alone. RRA in NOW cohort was administered to 49% of node-positive (pN1) patients and 17% of node-negative (pN0/NX) patients (P < 0.0001); TRR therefore, were examined separately for pN0/NX and pN1 patients. In 1157 pN0/NX cases, 20-year locoregional TRR were 3.1% after BT and were higher (P = 0.049) at 8.6% after BT+RRA. In four pN1 groups, stratified by metastatic nodal burden, RRA did not significantly reduce the locoregional TRR observed after BT with curative intent (P > 0.5).

Conclusions
In a 5-decade experience, RRA administered postoperatively to stage I APTC patients did not reduce either CSM or TRR and should probably not be indicated when such patients undergo potentially curative BT.
Guided Self-Help for Pediatric Obesity in Primary Care: A Randomized Clinical Trial
Authors: Rhee Kyung E. , Herrera Lourdes , Strong David , Kang-Sim Eastern , Shi Yuyan , Boutelle Kerri N. 
Published: June 2022

OBJECTIVES
Our aim was to compare the effect of 2 treatment models on attendance and child weight status: a less intense guided self-help (GSH) program delivered in the primary care setting versus traditional family-based behavioral treatment (FBT) delivered in an academic center.

METHODS
We conducted a randomized clinical trial among 164 children between 5 and 13 years old with a BMI ≥85th percentile and their parents. The intervention group (GSH) received 14 individual sessions over 6 months, with 5.3 hours of treatment. The control group (FBT) received 20 group-based sessions over 6 months, with 20 hours of treatment. Main outcomes included proportion of sessions families attended and change in child BMI z-score (BMIz), percentage from the 95th BMI percentile, difference from the 95th BMI percentile at the end of treatment, and 6-month follow-up.

RESULTS
Mean age of children was 9.6 years, BMI z-score 2.1, 49% female, and &gt;90% Latino. The odds of attending GSH compared to FBT was 2.2 (P &lt; 0.01). Those assigned to GSH had a 67% reduced risk of attrition (hazard ratio = 0.33, 95% confidence interval 0.22–0.50, P &lt; .001). Intent-to-treat analysis showed no between-group differences in change in BMIz and percentage from the 95th BMI percentile over time. Combined, there was a significant reduction in BMIz from baseline to posttreatment (β = −0.07 (0.01), P &lt; .01, d: 0.60) and a slight increase from posttreatment to follow-up (β = 0.007 (0.13), P = .56).

CONCLUSIONS
This study provides support for a novel, less intense GSH model of obesity treatment, which can be implemented in the primary care setting. Future studies should examine effective approaches to dissemination and implementation of GSH in different settings to increase access to treatment.
Dynamics of mental capacity of schoolchildren during study in secondary school under conditions of implementation of various educational programs
Authors: Sotnikova-Meleshkina Zhanna , Havrylova Tetiana , Zinchuk Olha , Dudnyk Iryna 
Published: June 2022

The aim: to describe the dynamic changes in mental capacity during education in secondary school in the implementation of traditional and meritocratic educational program.
Materials and methods. The study involved 56 secondary schoolchildren in the dynamics of learning, which were divided into 2 groups depending on the education system. The level of mental capacity was assessed using proofreading tests of V. Ya. Anfimov. Statistical data processing was performed using one-way analysis of variance and t-test in the software package IBM SPSS Statistics 20.
Results. During the period of basic education, the level of influence of the type of educational program, type of subject and day of the week on the accuracy of the test performance increased, the amount of work increased by 16.2-16.7 % (p<0.01) and its accuracy decreased (p<0,05). Higher initial and post-load intensity of mental capacity was revealed in schoolchildren with meritocratic education (353.23±8.52 and 341.41±8.65 respectively), and with a traditional system - higher and stable accuracy (5.68-5.86 errors) and productivity of mental work (35.29-35.72 conventional units; p<0.01). The weekly efficiency curve was the opposite in terms of accuracy for 6th and 9th grade schoolchildren, and the identical in terms of volume. In meritocratic education, a higher level of intensity was registered in the mathematics lesson, and in the traditional educational program − accuracy against the background of negative dynamics of quantitative and complex indicators.
Conclusions. Gender and age features of intensity, accuracy and productivity of mental work during basic education and the level of influence of factors of the educational process on them are established. The increase in the level of educational load was accompanied by an increase in the intensity and accuracy of mental work due to the adaptation of schoolchildren to the peculiarities of learning in secondary school and the stabilization of physiological processes. Comparison of weekly curves of mental capacity during training allowed to identify certain age trends in the formation of mental fatigue
Possibilities of effective formation of natural concepts in children of senior preschool age
Authors: Havrylo Olena , Kondratiuk Svitlana , Shapovalova Olha , Kharkova Yevdokiia 
Published: June 2022

The possibility of forming natural concepts in older preschool children is proved. Analyzed and selected in accordance with the purpose of the study, the definition of the term "concept" indicates that natural concepts are part of ecological competence of the child. Unlike representations, which reflect the object in a set of many different features, both significant and insignificant, the concepts carry a general, social experience, denote the essence of the object and distinguish it from all other objects. An important task of the teacher is to stimulate students' desire to acquire knowledge independently, to transform children in active participants in the educational process, to understand the essential features and connections of phenomena and objects of nature, which means to form concepts about them.
In the process of forming a natural concept, it is impossible to do without thinking operations, which include comparison, analysis, synthesis, abstraction and generalization. At about 5 years of age, there are significant changes in the child's thinking, but purposeful pedagogical influence will significantly increase the effectiveness of this.
In the course of the research methods, forms and techniques for the formation of natural concepts in students were selected. Verification of data formation initially took place at the ascertaining stage of the experiment and after the forming stage. Compared to the initial study, after organized work, the number of children with a high level of formation of natural concepts increased by 10 %, also the number of children with a medium level of formation increased by 7 %, and the number of low level decreased by 18 %. Thus, specially organized forms of work, selected methods and techniques help to form natural concepts in older preschool children
Peculiarities of implementation of lifelong learning policy in Turkey
Authors: Postryhach Nadiia 
Published: June 2022

The relevance of the study is due to the fact that in the 21st century, lifelong learning is recognized as one of the key pillars of education, closely intertwined with human development and financial growth. It is determined, that in recent years, major universities, governments and non-governmental organizations around the world continue to discuss the practice of lifelong learning. Being in the process of full membership in the EU, Turkey continues to comply with international norms and standards and comply with the established requirements.
The institutional efforts to support and disseminate adult education in Turkey, strengthen the vocational education and training system in the context of the implementation of the concept of lifelong learning were analized. It has been found, that in Turkey, the concept of lifelong has recently been seen as a model of approach to education and training. Turkey has been shown to need a long-term vision and strategy for adult learning as part of a broader lifelong learning strategy in order to increase adult learning opportunities.
The generalization of Turkey's progressive experience revealed the peculiarities of the implementation of lifelong learning policies, namely: ensuring the unity of national culture; implementing a strong policy of justice and equality in education; promotion of civic education; active participation in lifelong learning systems in order to build a competitive knowledge economy for the EU; promoting the literacy skills of Turkish citizens; training of qualified people in need of society; adaptation of non-formal and adult education to lifelong learning.
The generalization of vectors for expanding opportunities for adult learning in Turkey has identified promising areas for adult education in Ukraine, namely: investing in the expansion and diversification of learning spaces or opportunities in the field of lifelong learning; updating programs to support parents of young, children and adolescents; organization of trainings on raising awareness and skills of multi-literacy; recognition of certificates in the process of lifelong learning and non-formal education; conducting research on social consciousness for lifelong learning processes; supporting the development of a long-term adult learning strategy; expanding opportunities for adult learning, etc
Study of the radiation pattern of a rectangular horn antenna in the operation of multimode propagation of electromagnetic waves
Authors: Semenov Andriy , Semenova Olena , Pinaiev Bogdan , Kozin Dmytro , Shpylovyi Oleksandr 
Published: June 2022

The object of research in the work is the process of radiation of electromagnetic waves and the directional properties of a rectangular horn antenna in a multimode operation. The existing problem is that in practice when developing and researching horn antennas, only the single-mode mode of their operation is taken into account. The fundamental mode of the rectangular waveguide that feeds this horn antenna is chosen as the base mode of the emitted electromagnetic wave. Radiation of higher types of electromagnetic waves is not taken into account.
To take into account the impact of higher types of electromagnetic waves on the directional properties of a rectangular horn antenna, it is proposed to investigate a multimode mode consisting of three types of magnetic waves H10, H20, and H30. Horn antennas have high-quality wide-range properties and make it possible to obtain a maximum frequency coverage ratio of 1.5–1.8. In this paper, the directional properties of a rectangular horn antenna are determined by the example of calculating and modeling normalized radiation patterns of a standard horn-type for a wide frequency range with an average frequency of 12 GHz and a frequency overlap factor of 1.67.
It has been established that when emitting three higher types of waves, it is possible to simultaneously improve the characteristics and directional properties of a horn antenna by changing the amplitude of each component of the constituent waves of electromagnetic radiation. The work aimed to study the normalized radiation patterns of a rectangular horn antenna to improve its directional properties. It was found that with increasing frequency, starting from the middle frequency of the operating frequency range, the radiation pattern of a rectangular horn antenna expanded. That is, the opening angle increased in the direction of the main radiation, with a decrease in the radiation amplitude, the level of the side and rear lobes increased, which leads to a deterioration in the characteristics of the horn antenna. For the selected geometric dimensions of the horn antenna in the frequency range of 12–12.5 GHz in the multimode mode, it was possible to provide almost the same beam width in the horizontal and vertical planes at the level of 13.2–13.6°.
Analytical determination of energy intensity of critical deep cutting of soils by multi-scraper trench excavators
Authors: Kravets Svyatoslav , Forsiuk Serhii 
Published: June 2022

The object of research is the processes of interaction of the cutters of the working body of the chain trench excavator on the basis of the semi-blocked critical depth mode of soil cutting. One of the most problematic places is that the known analytical and experimental models of interaction of multi-scraper chain trench excavators with soil do not determine the parameters and modes of their operation based on critical depth cutting of soils. Therefore, the design of work equipment for given conditions on the basis of such dependencies does not provide the minimum energy consumption and maximum productivity of the work process.
The research used the method of analytical calculation of parameters of installation of soil-developing elements and determination of energy performance of multi-scraper chain working body of trench excavator on the basis of semi-blocked critical-depth soil cutting regime.
The proposed calculation method allows to determine the parameters of installation of the working body and placement of soil development elements and to quantify the energy performance of multi-scraper chain working body of the trench excavator based on semi-blocked critical depth of soil cutting mode.
The obtained method of calculation, in contrast to existing empirical estimates, allows developing options for improving the parameters of multi-scraper chain working body. As a substantiation of this conclusion the conceptual variant of technical realization of the working equipment is offered, namely, allows to prove expediency of the choice of the semi-blocked scheme of arrangement of cutters of critical deep cutting of soil of a working body of a trench multi-scraper excavator.
The conducted energy analysis showed that it is more expedient to use a multi-scraper chain working body of a trench excavator on the basis of a semi-blocked critical-depth regime of soil cutting. For example, for soil semi-solid clay with blocked cutting, cutting angle αc=20–30°, cutter width b=0.02 m the energy intensity of the working process varies within E=191–233 kJ/m3; for semi-blocked cutting under the same conditions – E=187–191 kJ/m3, which is 2–18 % less.
EN PRENSA Infestación intestinal por gregarinas en el camarón blanco Penaeus vannamei de cultivo en Nayarit, México EN PRENSA
Authors: ZAVALA LEAL O. I. , HERNÁNDEZ JAIME R. J. , VALDEZ GONZÁLEZ F. J. , MARTÍNEZ CÁRDENAS L. , GONZÁLEZ HUERTA C. A. , CUEVAS RODRÍGUEZ B. 
Published: June 2022

La presencia de gregarinas en el cultivo de camarón está asociada con una baja tasa de crecimiento. En esta industria, el tiempo de crecimiento es fundamental para el éxito del cultivo. Este trabajo describe la infestación intestinal por gregarinas en Penaeus vannamei, y evalúa un método de control del parásito. El muestreo se realizó durante mayo-agosto (temporada seca) y agosto-noviembre (temporada de lluvias) en cuatro granjas. Se determinó el grado de infestación y la prevalencia de gregarinas y su relación con la salinidad. Finalmente, se probó el antiparasitario comercial PREOXOL® (oxibendazol) al 1.5% como control contra estos parásitos, en la producción comercial. Se observó que la prevalencia de gregarinas en ambos ciclos de cultivo fue alta, osciló entre el 75 y el 90% en la estación seca y entre el 70 y el 87% en la estación lluviosa. El grado de severidad de la infestación fue mayor en la estación seca. La salinidad registrada durante la estación seca osciló entre 26 y 47 UPS, mientras que en el ciclo de lluvias fue de 6 a 26 UPS. Se observó que existe una correlación positiva entre el grado de severidad y la salinidad. El antiparasitario logró disminuir la prevalencia de gregarinas más del 90 %. Mientras que el grado de severidad disminuyó hasta en tres grados. Existe una correlación positiva entre el grado de severidad y la salinidad, no así con la prevalencia. El método de control empleado con PREOXOL® resultó ser altamente eficiente en la producción comercial de camarón.
COVID-19 PANDEMİSİNİ TAKİBEN KOLOREKTAL KARSİNOM VAKALARININ DEMOGRAFİK VE KLİNİK ÖZELLİKLERİNDE MEYDANA GELEN DEĞİŞİKLİKLER
Authors: ÖZDEMİR Dursun Burak , KARAYİĞİT Ahmet , DİZEN Hayrettin , ÜNAL Bülent 
Published: June 2022

Amaç
Bu çalışma, Covid-19 pandemisinden önce ve sonra
başvuran kolorektal karsinomlu hastaların demografik,
klinik ve patolojik özelliklerini karşılaştırmayı
amaçladı.
Gereç ve Yöntem
Pandemiden 9 ay önce ve ilk 9 ay içinde başvuran
olgular çalışmaya dahil edildi. Bu çalışmanın birincil
sonuç ölçütü, iki dönem boyunca invaziv kolorektal
karsinomlu hastaların klinik ve patolojik özelliklerindeki
farklılıktı.
Bulgular
Pandemi öncesi ve pandemi sonrası hastalar yaş,
cinsiyet, tümör yerleşimi, tümör boyutu, lenf nodu invazyonu,
farklılaşma, senkron tümör varlığı, radyal
ve distal cerrahi sınır pozitifliği, perinöral ve lenfovasküler
invazyon, TNM evresi, karaciğer metastazı ve
nüks bakımından benzerdi. Pandemi öncesi döneme
göre fark istatistiksel olarak anlamlı olmasa da, pandemi
sonrası hastalarda ileuslu 3 hasta (%4,7) ve tümör
perforasyonu olan 2 hasta (%3,2) belirledik.
Sonuç: Bulgularımız, pandemi sonrası dönemde
kolorektal karsinom nedeniyle ameliyat olan hasta
sayısında, muhtemelen hastanelerdeki sağlık organizasyonundaki
yapısal değişiklikler ve hastaların
SARS-CoV-2 ile olası enfeksiyon nedeniyle sağlık
hizmetine başvuruda tereddüt etmesi nedeniyle pandemi
öncesi döneme göre hafif bir azalma olduğunu
göstermektedir. Sağlık sistemlerinin, Covid-19 salgını
sırasında maligniteler gibi ciddi klinik durumları yönetmenin
yeni yollarını bulmaya çalışması gerektiği
açıktır.
MANAJEMEN SARANA DAN PRASARANA DALAM MENINGKATKAN KUALITAS PENDIDIKAN DI SMP PLUS AL-KAUTSAR MALANG
Authors: Murod Mohammad 
Published: June 2022

ABSTRACT : Along with the development of the era which is always advancing rapidly in the era of science and technology, education is required to further improve the quality of education. To achieve this in an educational institution, there are important components that influence the development of quality education, namely the management of educational facilities and infrastructure.
This study aims to find answers from the focus of research on planning, implementing, and evaluating facilities and infrastructure, as well as the impact of improving the quality of education in the implementation of facilities and infrastructure management at SMP Plus Al-Kautsar Malang. In this study, the researcher uses qualitative research methods accompanied by a case study approach which has the aim of achieving the previously determined subject. Therefore, the researcher did it at the research location by looking directly at the condition of the object to be studied. In collecting data, the researcher used interview, observation and documentation techniques. To determine the validity of the data in this study, the researchers used data triangulation techniques, methods and sources. Data reduction, data presentation, and drawing conclusions are techniques in analyzing the data in this study.
Abstrak: Seiring berkembangnya zaman yang senantiasa semakin maju dengan pesat di era ilmu pengetahuan maupun teknologi, pendidikan dituntut untuk lebih meningkatkan kualitas pendidikan. Untuk mencapai hal tersebut pada suatu lembaga pendidikan terdapat komponen penting yang mempengaruhi untuk mengembangkan pendidikan yang berkualitas, yaitu manajemen sarana dan prasarana pendidikan.
Penelitian ini memiliki tujuan untuk menemukan jawaban terkait perencanaan, pengimplementasian, dan evaluasi manajemen sarana dan prasarana, serta dampak dari peningkatan kualitas pendidikan dalam implementasi manajemen sarana dan prasarana di SMP Plus Al-Kautsar Malang. Pada penelitian ini, peneliti menggunakan metode penelitian kualitatif disertai dengan pendekatan studi kasus yang memiliki tujuan mencapai perihal yang sebelumnya telah ditetapkan. Maka dari itu, peneliti melakukannya di lokasi penelitian dengan melihat secara langsung kondisi objek yang akan diteliti. Dalam mengumpulkan data, peneliti menggunakan teknik wawancara, observasi serta dokumentasi. Untuk mengetahui keabsahan data pada penelitian ini, peneliti menggunakan teknik triangulasi data, metode dan sumber. Reduksi data, penyajian data, serta penarikan kesimpulan menjadi teknik dalam menganalisis data pada penelitian ini.
Szülői segítségnyújtás az iskolai tanulmányi feladatok teljesítésében - Szülői kommunikáció – II. Rész
Authors: Szász Mária Magdolna 
Published: June 2022

Az iskola és család közötti hatékony kommunikáció előfeltétele és elengedhetetlen része a hatékony szülő-oktató partnerségek kialakításához. A tanulmány azt elemzi, hogy a Palts és Harro-Loit (2015) szerzőpáros által megalkotott öt szülői kommunikációs minta (aktív pozitív; aktív-negatív; passzív-pozitív és passzív-negatív, kommunikációban jártas rugalmas szülők) Kászon-térségben hogyan van jelen és milyen mértékben a pedagógus-szülő kommunikációban. A vizsgált térségben leggyakoribb a passzív-pozitív, valamint a passzív-negatív szülőtípus.