bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of low‐intensity extracorporeal shock wave therapy in the management of interstitial cystitis/bladder pain syndrome patients: A thirty case study in a tertiary medical center
Authors: Jhang Lan‐Sin , Hsieh Wu‐Chiao , Huang Ting‐Xuan , Chou Yi‐Chun , Lo Tsia‐Shu , Liang Ching‐Chung , Lin Yi‐Hao 
Published: September 2022

AbstractIntroductionLow‐energy extracorporeal shock wave therapy (LiESWT) is a new potential treatment for intractable interstitial cystitis/bladder pain syndrome (IC/BPS), and this paper will evaluate its therapeutic effects on IC/BPS.Materials and MethodsThis prospective clinical trial enrolled 30 women who have been diagnosed with IC/PBS to receive LiESWT treatment at an intensity of 0.25 mJ/mm2 and a frequency of 3 pulses/second, for a total of 3000 pulses within 8 weeks. And we assessed questionnaires (including O'Leary‐Sant Interstitial Cystitis Symptom Index (ICSI)), 3‐day voiding diary, and urodynamic study at the following intervals: 4 weeks of LiESWT (W4), 8 weeks of LiESWT (W8), 1‐month follow‐up (F1), 3‐month follow‐up (F3) after LiESWT, and 1 year follow‐up (F12).ResultsThe primary outcome of questionnaires showed significant improvement of symptoms compared to baseline (W0), especially on ICSI(12.87 ± 3.44 before treatment and 7.87 ± 5.27 at F12, p < 0.05). 3‐day voiding diary also revealed significant decrease in daytime voiding frequency (15.57 ± 5.22 times before treatment and 10.70 ± 4.21 times at F1, p < 0.05) and significant increase on average voiding volume (95.85 ± 35.30 mL before treatment and 161.27 ± 74.21 mL at F1, p < 0.05). However, there were no significant differences in all parameters of the urodynamic study.ConclusionLiESWT can mitigate pain and lower urinary tract symptoms and improve the quality of life in IC/PBS patients, but does not increase the maximal cystometric capacity.
Sketch‐and‐project methods for tensor linear systems
Authors: Tang Ling , Yu Yajie , Zhang Yanjun , Li Hanyu 
Published: September 2022

AbstractFor tensor linear systems with respect to the popular t‐product, we first present the sketch‐and‐project method and its adaptive variants. Their Fourier domain versions are also investigated. Then, considering that the existing sketching tensor or way for sampling has some limitations, we propose two improved strategies. Convergence analyses for the methods mentioned above are provided. We compare our methods with the existing ones using synthetic and real data. Numerical results show that they have quite decent performance in terms of the number of iterations and running time.
The U‐shaped association between hospitalization time and fall incidence in inpatients using publicly available data: A cross‐sectional study in Japan
Authors: Chen Zihong , Zhong Qiang , Chen Yonghong , Chen Lihua , Peng Huanhuan 
Published: September 2022

AbstractAimTo examine the association between the hospitalization time and fall incidence.DesignA secondary analysis using the Dryad Digital Repository public database.MethodsData were extracted from the Fukushima Medical University Hospital cohort study between August 2008 and September 2009. The final analytic sample included 8,598 participants, 156 of who fell. The risk of fall incidents according to hospitalization time was estimated using logistic proportional hazards models, and restricted cubic splines with four knots model were developed.ResultsThe median hospitalization time was 9.00 (4.00, 17.00) days. The incidence of falls was 1.81% (N = 156). A U‐shaped association between the hospitalization time and fall incidence, with an inflextion point of 8 days. We found a decreasing fall incidence as the hospitalization time increased from 0 to 8 days (OR 0.72 [0.62 ~ 0.83], p < .001); beyond 8 days, the fall incidence increased as the hospitalization time increased (OR 1.06 [1.04 ~ 1.09]).
Sodium Persulfate Pre‐treatment of Copper Foils Enabling Homogenous Growth of Cu(OH)2 Nanoneedle Films for Electrochemical CO2 Reduction
Authors: Gustavsen Kim Robert , Johannessen Erik Andrew , Wang Kaiying 
Published: September 2022

AbstractOxide‐derived copper (OD−Cu) catalysts have received widespread attention for their ability to produce energy‐dense multicarbon products. Within this class of materials, nanostructured copper hydroxide (Cu(OH)2) has shown excellent catalytic properties, but its synthesis requires complex pre‐treatment steps of the Cu surface. In this study, we have developed a simple two‐step synthesis method for homogenous Cu(OH)2 nanoneedle films using a sodium persulfate pre‐treatment step prior to anodization. The Cu(OH)2 nanoneedle films show drastically enhanced uniformity after the pre‐treatment due to improved current distribution and can be grown over large surface areas (63 cm2). As a catalyst for CO2 reduction, the Cu(OH)2 favours ethylene formation, with a near total suppression of methane production. A peak faradaic efficiency (FE) of 36.5 % is found at −1.0 V vs. the reversible hydrogen electrode (RHE), and the catalyst remains stable while providing an ethylene to methane ratio of 27.8 after 6 h of reaction.
Tribological properties of oriented polytetrafluoroethylene at room temperature and cryogenic temperature
Authors: Cai Peng , Zhao Meng , Zhao Bingbing , Zhao Gai , Zheng Fei , Ni Lingli 
Published: September 2022

AbstractIn this study, the tribological properties of drawn PTFE were tested on a CSM tribometer at room temperature and cryogenic temperature. The orientation degree and worn surface morphology of drawn PTFE were studied and correlated with the friction and wear behaviors. It was found that the sample with low friction coefficient corresponded to high orientation degree in the parallel direction at room temperature, while the friction coefficient barely changed with increasing draw ratio in the perpendicular direction. The friction coefficient of drawn PTFE at liquid nitrogen temperature is higher than that at room temperature in the perpendicular direction, while the two values are almost undistinguishable within error range in the parallel direction. The wear volume of drawn PTFE at liquid nitrogen temperature is lower than that at room temperature in both perpendicular and parallel directions due to the mitigation of adhesive wear of drawn PTFE under liquid nitrogen temperature.
Embedding equity into school mental health theory: Introduction to Part 2 of the special issue series
Authors: Gaias Larissa , Jones Janine , Exner‐Cortens Deinera , Splett Joni , Walker Whitney 
Published: September 2022

AbstractIn this article, we present an introduction to the second part of a two‐part special series focused on embedding equity into school mental health. In the previous part, we focused on measurement and practice, and in this second part, we focus on theory.
Splenic artery embolization for treatment of portal hypertension due to essential thrombocythemia
Authors: Liu Jiacheng , Liu Xiaoming , Xiong Bin 
Published: September 2022

AbstractPhiladelphia‐negative myeloproliferative neoplasms (MPNs) are significantly associated with the development of splanchnic vein thrombosis, which leads to portal hypertension. Here, we report two rare cases of portal hypertension caused by essential thrombocythemia (a type of MPN). Splenic artery embolization was performed to prevent variceal rebleeding, and during follow‐up, no rebleeding occurred in these two cases.
TGFβ1 and POSTN as biomarkers of postinfectious bronchiolitis obliterans and asthma in children
Authors: Kang Mi‐Jin , Ahn Hee‐Sung , Lee So‐Yeon , Yeom Jeonghun , Kim Kyunggon , Hong Soo‐Jong 
Published: September 2022

AbstractRationaleAsthma and postinfectious bronchiolitis obliterans (PIBO) are common chronic lung diseases in company with wheezing in children. However, it is not clear what is common and unique mechanisms between the two diseases. Thus, we used proteomic analysis to compare differences in biomarkers between children with asthma and PIBO.MethodsOverall, 30 healthy children without respiratory underlying diseases, 18 children with asthma and 15 with PIBO were included for this study. Sequential window acquisition of all theoretical mass spectra (SWATH)‐mass spectrometry (MS) was used to measure proteins in plasma samples. To identify specific pathways of each groups, we used the ingenuity pathway analysis (IPA) software.ResultsWe identified and quantified 354 proteins across all 63 samples in the SWATH‐MS analysis. Forty eight proteins were significantly different among 3 groups. The upstream analysis of IPA suggested that inhibitor of nuclear factor kappa B kinase subunit beta (IKBKB) was the upstream inhibitor of 4 differentially expressed proteins (DEPs) in asthma, while the upstream activator in PIBO subjects. Among 4 DEPs, TGF‐β1 in PIBO and periostin in asthma were negatively correlated with forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity, maximal med‐expiratory flow, and PC20, respectively.ConclusionThese findings demonstrate that transforming growth factor β1 and periostin were unique biomarkers of PIBO and asthma in children, respectively. The mechanism regulated by IKBKB may be therapeutically relevant for PIBO and asthma.
Delta variant effect on the clinical course of adolescent COVID‐19 patients
Authors: Çağlar Hanife Tuğçe , Pekcan Sevgi , Yılmaz Aslı İmran , Ünal Gökçen , Metin Akcan Özge , Ünsaçar Mahmut Z. , Özdemir Mehmet , Akın Fatih 
Published: September 2022

AbstractObjectiveThe clinical course of new COVID‐19 variants in adolescents is still unknown. The aim of this study is to evaluate the clinical characteristics of COVID‐19 in adolescents and compare the differences between the original version and the delta variant.Materials and MethodsThe medical records of patients aged 10−18 years treated for COVID‐19 between April 1, 2020 and March 31, 2022 were retrospectively reviewed. Patients were divided into four groups (asymptomatic, mild, moderate, and severe) for COVID‐19 severity and into two groups according to the diagnosis date (first−second year). The primary endpoint of the study was hospital admission.ResultsThe mean age of patients was 171.81 ± 29.5 months, and most of them were males (n: 435, 53.3%). While the patient number was 296 (43.52%) in the first year of pandemic, it raised to 520 (54.11%) in the second year (p < 0.01). The severity of COVID‐19 was mild in 667 (81.7%) patients. In the comparison of patients according to the diagnosis date (first−second years); the parameters of anosmia, ageusia, weakness, muscle pain, vomiting, hospital admission, and length of stay in hospital were statistically different (p < 0.05). In the comparison of hospitalized patients between years, the necessity of oxygen support (p < 0.001), endotracheal intubation rates (p < 0.05), length of stay in the hospital (p < 0.001), and the severity of COVID‐19 (p < 0.05) was significantly higher in the second year.ConclusionThe clinical course for adolescents diagnosed with COVID‐19 has linearly changed with the delta variant. Our results confirmed that the delta variant is more transmissible, requires more oxygen support, increases endotracheal intubation, and prolongs the length of stay in the hospital.
Chronic tracheostomy care of ventilator‐dependent and ‐independent children: Clinical practice patterns of pediatric respirologists in a publicly funded (Canadian) healthcare system
Authors: St‐Laurent Aaron , Zielinski David , Qazi Adam , AlAwadi Aceel , Almajed Athari , Adamko Darryl J. , Alabdoulsalam Tareq , Chiang Jackie , Derynck Michael , Gerdung Chris , Kam Karen , Katz Sherri L. , MacLusky Ian , Mehta Kevan , Mateos Dimas , Nguyen The Thanh D. , Praud Jean‐Paul , Proulx Frederic , Seear Michael , Smith Mary Jane , Wensley David , Amin Reshma 
Published: September 2022

AbstractObjectivesTo describe the current clinical practice patterns of Canadian pediatric respirologists at pediatric tertiary care institutions regarding chronic tracheostomy tube care and management of home invasive ventilation.MethodsA pediatric respirologist/pediatrician with expertise in tracheostomy tube care and home ventilation was identified at each Canadian pediatric tertiary care center to complete a 59‐item survey of multiple choice and short answer questions. Domains assessed included tracheostomy tube care, caregiver competency and home monitoring, speaking valves, medical management of tracheostomy complications, decannulation, and long‐term follow‐up.ResultsThe response rate was 100% (17/17) with all Canadian tertiary care pediatric centers represented and heterogeneity of practice was observed in all domains assessed. For example, though most centers employ Bivona™ (17/17) and Shiley™ (15/17) tracheostomy tubes, variability was observed around tube change, re‐use, and cleaning practices. Most centers require two trained caregivers (14/17) and recommend 24/7 eyes on care and oxygen saturation monitoring. Discharge with an emergency tracheostomy kit was universal (17/17). Considerable heterogeneity was observed in the timing and use of speaking valves and speech‐language assessment. Inhaled anti‐pseudomonal antibiotics are employed by most centers (16/17) though the indication, agent, and protocol varied by center. Though decannulation practices varied considerably, the requirement of upper airway patency was universally required to proceed with decannulation (17/17) independent of ongoing ventilatory support requirements.ConclusionConsiderable variability in pediatric tracheostomy tube care practice exists across Canada. These results will serve as a starting point to standardize and evaluate tracheostomy tube care nationally.
Development of mortality prediction models for infants with isolated, left‐sided congenital diaphragmatic hernia before and after birth
Authors: Yoneda Kota , Amari Shoichiro , Mikami Masashi , Uchida Keiichi , Yokoi Akiko , Okawada Manabu , Furukawa Taizo , Toyoshima Katsuaki , Inamura Noboru , Okazaki Tadaharu , Yamoto Masaya , Masumoto Kouji , Terui Keita , Okuyama Hiroomi , Hayakawa Masahiro , Taguchi Tomoaki , Usui Noriaki , Isayama Tetsuya 
Published: September 2022

AbstractBackgroundMortality prediction of congenital diaphragmatic hernia (CDH) is essential for developing treatment strategies, including fetal therapy. Several researchers have reported prognostic factors for this rare but life‐threatening condition; however, the optimal combination of prognostic factors remains to be elucidated.ObjectivesThis study aimed to develop the most discriminative prenatal and postnatal models to predict the mortality of infants with an isolated left‐sided CDH.MethodsThis multi‐institutional retrospective cohort study included infants with CDH born at 15 tertiary hospitals of the Japanese CDH Study Group between 2011 and 2016. We developed multivariable logistic models with every possible combination of predictors and identified models with the highest cross‐validated area under the receiver operating characteristic curve (AUC) for prenatal and postnatal predictions.ResultsAmong 302 eligible infants, 44 died before discharge. The prenatal mortality prediction model was based on the observed/expected lung area to head circumference ratio (O/E LHR), liver herniation, and stomach herniation (AUC, 0.830). The postnatal mortality prediction model was based on O/E LHR, liver herniation, and the lowest oxygenation index (AUC, 0.944).ConclusionOur models can facilitate the prenatal and postnatal mortality prediction of infants with isolated left‐sided CDH.
Metformin use and mortality in Asian, diabetic patients with prostate cancer on androgen deprivation therapy: A population‐based study
Authors: Lee Yan Hiu Athena , Hui Jeremy Man Ho , Chan Jeffrey Shi Kai , Liu Kang , Dee Edward C. , Ng Kenrick , Tang Pias , Tse Gary , Ng Chi Fai 
Published: September 2022

AbstractBackgroundThis study aims to examine the associations between metformin use concurrent with androgen deprivation therapy (ADT) and mortality risks in Asian, diabetic patients with prostate cancer (PCa).MethodsThis study identified diabetic adults with PCa receiving any ADT attending public hospitals in Hong Kong between December 1999 and March 2021 retrospectively, with follow‐up until September 2021. Patients with <6 months of medical castration without subsequent bilateral orchidectomy, <6 months of concurrent metformin use and ADT, or missing baseline HbA1c were excluded. Metformin users had ≥180 days of concurrent metformin use and ADT, while non‐users had no concurrent metformin use and ADT or never used metformin. The primary outcome was PCa‐related mortality. The secondary outcome was all‐cause mortality. The study used inverse probability treatment weighting to balance covariates.ResultsThe analyzed cohort consisted of 1971 patients (1284 metformin users and 687 non‐users; mean age 76.2 ± 7.8 years). Over a mean follow‐up of 4.1 ± 3.2 years, metformin users had significantly lower risks of PCa‐related mortality (weighted hazard ratio [wHR]: 0.49 [95% confidence interval, CI: 0.39–0.61], p < 0.001) and all‐cause mortality (wHR 0.53 [0.46–0.61], p < 0.001), independent of diabetic control or status of chronic kidney disease. Such effects appeared stronger in patients with less advanced PCa, which is reflected by the absence of androgen receptor antagonist or chemotherapy use (p value for interaction: 0.017 for PCa‐related mortality; 0.048 for all‐cause mortality).ConclusionsMetformin use concurrent with ADT was associated with lower risks of mortality in Asian, diabetic patients with PCa.
Safely omitting bone isotope scans in a cohort of grade group 2 prostate cancer
Authors: Mustaffa Ali , Emara Shady 
Published: September 2022

AbstractObjectiveA retrospective review conducted in our urology unit to assess the efficiency for requesting bone scans for newly diagnosed prostate cancer patients, aiming to minimize radiation exposure and avoiding unnecessary investigations as cost effective measure.MethodsA retrospective observational study included 360 patients with newly diagnosed prostate cancer within urology department at Calderdale and Huddersfield NHS Trust from April 2016 to March 2018. Parameters observed were: the prostatic specific antigen (PSA) on diagnosis, Gleason score, staging magnetic resonance imaging, and bone scans. We analyzed the possible correlation of the Gleason score and PSA to determine the risk of bony metastasis. Regarding PSA: Patients were categorized as with PSA <15, PSA ≥15. Regarding Gleason score: Patients were categorized as patients with grade group 1 or 2 and patients with grade group 3 and above. Data recorded was then analyzed using χ2 analysis to determine if results were deemed significant or not.ResultsA total of 360 patients: 91 patients (25%) had positive bony metastasis. While 269 patients (75%) had a clear bone scan. Among patients with grade group 3 or above or having PSA ≥15, 90 patients out of 324 patients had bony metastasis (38%). Among patients with grade group 1 or 2 and PSA <15, only 1 patient out of 36 had bony metastasis (2.7%). Negative predictive value of grade group 1 or 2 and PSA <15 for bony metastasis was 97.22%.ConclusionUsing a cutoff level of PSA <15 in grade group 1 and 2 seems to be a safe and efficient tool to exclude newly diagnosed prostate cancer patients from having an isotope bone scan for staging purpose.
Long‐term outcomes of radical prostatectomy versus low‐dose‐rate brachytherapy in patients with intermediate‐risk prostate cancer: Propensity score matched comparison
Authors: Urabe Fumihiko , Miki Kenta , Kimura Takahiro , Sasaki Hiroshi , Tashiro Kojiro , Iwatani Kosuke , Matsukawa Akihiro , Aikawa Koichi , Tsusumi Yuki , Morikawa Midoriko , Minato Kyosuke , Sato Shun , Takahashi Hiroyuki , Aoki Manabu , Egawa Shin 
Published: September 2022

AbstractPurposeTo compare long‐term outcomes of radical prostatectomy (RP) and low‐dose‐rate brachytherapy (LDR‐BT) using propensity score‐matched analysis in patients with clinically localized, intermediate‐risk prostate cancer (PCa).MethodsBetween October 2003 and March 2014, our institution treated 1241 patients with intermediate‐risk PCa (RP: n = 531; LDR‐BT: n = 710). Biochemical recurrence (BCR) was defined as prostate‐specific antigen (PSA) levels of 0.2 ng/ml or greater for RP, and as PSA nadir plus 2 ng/ml or higher (Phoenix definition) for LDR‐BT. We calculated propensity scores by multivariate logistic regression based on covariates that included age, pretreatment PSA, biopsy Gleason grade, the percentage of positive biopsy cores (PPBC), and clinical T stage.ResultsMedian follow‐up was 108 months for RP and 99 months for LDR‐BT. After propensity score adjustment, a total of 642 (321 each) patients remained for further analysis. Kaplan–Meier curves showed no statistically significant difference in overall survival (OS) (p = 0.99). LDR‐BT was associated with improved BCR‐free survival and salvage therapy‐free survival compared to RP (p < 0.001), and RP was associated with improved metastasis‐free survival (MFS, p < 0.001).ConclusionBCR cannot be a surrogate for survival comparison, primarily due to differences between treatment modalities in how this term was defined post‐therapy. Long‐term follow‐up showed that RP was associated with lower MFS in intermediate‐risk PCa. However, this has not yet translated into superior OS.
Yeast mediates the interspecific interaction between introduced Bactrocera dorsalis and indigenous Bactrocera minax
Authors: Ren Xue‐Ming , Yang Yi‐Shi , Guo Ru‐Xin , Wang Hao‐Ran , Qi Xue‐Wei , Cao Shuai , Lai Yan‐Nan , Zhang Gui‐Jian , Niu Changying 
Published: September 2022

AbstractBackgroundHost plant–microbe associations mediate interspecific interactions amongst herbivorous insects. However, this theory has rarely been ecologically verified in tephritid fruit flies. Research on this subject can not only help predict tephritid species invasion and occurrence patterns, but also develop potential novel lures for the control of the tephritid fruit fly pests. Recently, we observed mixed infestation of Bactrocera minax and Bactrocera dorsalis larvae in citrus orchards, which prompted us to explore the underlying mechanism.ResultsFollowing oviposition by B. minax, the yeast Pichia kluyveri translocated to and proliferated inside the citrus fruit. The level of d‐limonene released from citrus fruits containing P. kluyveri was 27 times higher than that released from healthy fruits. Mature B. dorsalis females were attracted to d‐limonene and oviposited into fruits previously infested by B. minax. Furthermore, the interspecific interaction between B. dorsalis and B. minax within the same fruit significantly decreased the number of surviving larvae and pupal weight in B. dorsalis, but its effect on B. minax was weaker.ConclusionIn the studied interspecific interaction, B. minax occupies the dominant position, implying ecological significance for this species in terms of consolidating its own niche and inhibiting the invasion of exotic species. To our best knowledge, this is the first report from both ecological and physiological perspectives on a symbiotic yeast mediating the interaction between B. minax and B. dorsalis through altering fruit volatiles. © 2022 Society of Chemical Industry.