bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported mental well-being of mothers with young children during the first wave of the COVID-19 pandemic in Germany: A mixed-methods study
Authors: Wandschneider Lisa , Batram-Zantvoort Stephanie , Alaze Anita , Niehues Vera , Spallek Jacob , Razum Oliver , Miani Céline 
Published: August 2022

Objectives: Mothers of young children have been identified as a particularly vulnerable group during the COVID-19 pandemic. We aimed to explore how occupational, psychosocial and partnership-related factors were associated with their self-reported mental well-being during the first COVID-19 wave. Methods: Five hundred fifty participants of the BaBi cohort study (est. 2013, Bielefeld, North-Rhine Westphalia, Germany) were invited to complete an online survey and to take part in email interviews (April–May 2020). With survey data, we assessed self-reported mental well-being through validated instruments (eight-item Patient Health Questionnaire; short version of the Symptom Checklist) and ran linear regression models for occupational, psychosocial and partnership-related factors. We performed content analysis on the interviews’ data to further understand the determinants of the women’s mental well-being. Results: One hundred twenty-four women participated in the survey; of which 17 also participated in the interviews. A perceived lack of support in childcare was associated with higher levels of depressive symptoms, while having a higher internal locus of control was associated with lower levels. Psychological distress was higher in those reporting lack of emotional or childcare support. Interviews confirmed the interplay of potential stressors and highlighted the difficulties to reconcile different expectations of motherhood. Discussion: Occupational, psychosocial and partner-related factors can act (to varying degree) both as resources and stressors to the self-reported mental well-being of mothers of young children. These impacts took different forms and created opportunities or challenges, depending on specific life circumstances, such as work or family situations, relationships and own psychosocial resources. Although not representative, our study contributes to building the COVID-19 evidence base, delineating the mental health toll of the pandemic on mothers of young children and the factors that contribute to it.
Algorithmic prediction of anaesthesia manpower quantity needs: A multicentre study
Authors: Akavipat Phuping , Suraseranivongse Suwannee , Yimrattanabowon Patcharee , Sriraj Wimonrat , Ratanachai Prapa , Summart Ueamporn 
Published: August 2022

Background: A shortage of anaesthetists affects health system globally. This is a study on task-force to develop a predictive model for the appropriate number of anaesthetic providers (Y). Methods: A cross-sectional study was performed with randomisation from every health service region across Thailand. The decision-making criteria for manpower needed were written and provided guidance. The number of personnel was calculated from the sum of total time spent by all anaesthetic providers divided by duration of the service. Linear regression analysis was applied. Results: In total 3774 patients were included from 18 hospitals. The factors that affect the anaesthetic providers’ allocation needs were included in the predictive model, calculated as Y = 3.53 + [0.56 (standard centre) + 0.36 (advanced centre) + 1.03 (specialty centre)] + 0.07 (American Society of Anesthesiologists physical status IV and V) + 0.61 (advanced anaesthetic medication) + [0.61 (monitored anaesthesia care) + 0.17 (general anaesthesia)] − [0.27 (pre-anaesthetic duration within 31–60 minutes) + (0.61 (over 60 minutes)] − [0.85 (anaesthetic duration within 31–60 minutes) + 1.04 (within 61–120 minutes) + 1.32 (over 120 minutes)] – [0.16 (post-anaesthetic duration within 31–60 minutes) + 0.45 (within 61–90 minutes) + 0.74 (over 90 minutes)]. Conclusion: The anaesthesia manpower algorithm developed during this study can be used to calculate the number of anaesthetists per population to maintain health services.
Ureteroscopy for stone disease in the paediatric population: lessons learned and outcomes in a Nordic setting
Authors: Juliebø-Jones Patrick , Æsøy Mathias Sørstrand , Gjengstø Peder , Beisland Christian , Ulvik Øyvind 
Published: August 2022

Introduction: Paediatric stone disease is rare in the Nordic communities. Still, the condition can require surgical intervention in the form of ureteroscopy (URS). Here, we report outcomes achieved at a regional (tertiary) centre. Patients and methods: Retrospective analysis was performed of consecutive patients (<18 years of age) undergoing URS for stone disease between 2010 and 2021. Outcomes of interest included stone-free rate (SFR) determined using a definition of no residual fragments ⩾ 3 mm on imaging and complications classified according to Clavien–Dindo system. Results: In total, 23 patients underwent 47 URS procedures for a total of 31 stone episodes. Mean age was 9 (range 1–17) years and male-to-female ratio was 6:17. Overall, 35% had at least one medical comorbidity. Ultrasound determined preoperative stone status in 87%. Mean largest index and cumulative stone sizes were 9 (range 3–40) and 12 (range 3–40) mm, respectively. Overall, 32% had multiple stones. Lower pole was the commonest stone location (39%). No patients underwent elective pre-operative stenting. Ureteral access sheaths were not used in any cases. Access to upper urinary tract at first procedure was successful in 94%. Initial and final SFR was 61% and 90%, respectively. No intra-operative complications were recorded. Overall post-operative complication rate was 17.5%. Urinary tract infection (CD II) was the commonest adverse event (12.5%). Conclusion: Paediatric URS can be delivered in the setting of a regional centre without compromising outcomes. This includes when carried out by adult endourologists, without routine pre-stenting and omitting use of ureteric access sheath.
Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer
Authors: Denault Elyssa , Nakajima Erika , Naranbhai Vivek , Hutchinson Jennifer A. , Mortensen Lindsey , Neihoff Elizabeth , Barabell Caroline , Comander Amy , Juric Dejan , Kuter Irene , Mulvey Theresa , Peppercorn Jeffrey , Rosenstock Aron S. , Shin Jennifer , Vidula Neelima , Wander Seth A. , Moy Beverly , Ellisen Leif W. , Isakoff Steven J. , Iafrate A. John , Gainor Justin F. , Bardia Aditya , Spring Laura M. 
Published: August 2022

Purpose: To explore the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with breast cancer based on type of anticancer treatment. Methods: Patients with breast cancer had anti-spike antibody concentrations measured ⩾14 days after receiving a full SARS-CoV-2 vaccination series. The primary endpoint was IgA/G/M anti-spike antibody concentration. Multiple regression analysis was used to analyze log10-transformed antibody titer concentrations. Results: Between 29 April and 20 July 2021, 233 patients with breast cancer were enrolled, of whom 212 were eligible for the current analysis. Patients who received mRNA-1273 (Moderna) had the highest antibody concentrations [geometric mean concentration (GMC) in log10: 3.0 U/mL], compared to patients who received BNT162b2 (Pfizer) (GMC: 2.6 U/mL) (multiple regression adjusted p = 0.013) and Ad26.COV2.S (Johnson & Johnson/Janssen) (GMC: 2.6 U/mL) ( p = 0.071). Patients receiving cytotoxic therapy had a significantly lower antibody titer GMC (2.5 U/mL) compared to patients on no therapy or endocrine therapy alone (3.0 U/mL) ( p = 0.005). Patients on targeted therapies (GMC: 2.7 U/mL) also had a numerically lower GMC compared to patients not receiving therapy/on endocrine therapy alone, although this result was not significant ( p = 0.364). Among patients who received an additional dose of vaccine ( n = 31), 28 demonstrated an increased antibody response that ranged from 0.2 to >4.4 U/ mL. Conclusion: Most patients with breast cancer generate detectable anti-spike antibodies following SARS-CoV-2 vaccination, though systemic treatments and vaccine type impact level of response. Further studies are needed to better understand the clinical implications of different antibody levels, the effectiveness of additional SARS-CoV-2 vaccine doses, and the risk of breakthrough infections among patients with breast cancer.
Maternity Healthscapes: Conceptualization and Index Development
Authors: Martens Carmen , Delcourt Cécile , Petermans Ann 
Published: August 2022

Objectives: This article provides a conceptualization and an index of the multidimensional concept of maternity healthscapes (MHS). Background: Healthscape has emerged as a potential key aspect to improve patient experience. Surprisingly, there has been little effort to delineate the concept of MHS from a design perspective, while maternity wards have unique characteristics and particular challenges. Indeed, patients in maternity wards are usually not acutely ill but can feel highly vulnerable due to the pain, stress, and the many uncertainties surrounding labor and delivery—which can heighten patients’ need for intimacy, supporter comfort, and additional supporting services. Thus, healthscapes need to be designed to account for the specificities of childbearing and needs of those patients and their family. Methods: A multidisciplinary literature review and 39 in-depth interviews were conducted with various stakeholders—mothers, midwives, heads of midwives, and chief executives. Results: The authors develop a conceptualization to establish a comprehensive understanding of the dimensionality of MHSs. Based on that comprehensive conceptualization, the authors develop an index providing a census of the aspects in the MHS that various stakeholders—such as healthcare providers, designers, and architects—should take into account when conceiving MHS. Conclusions: Healthcare providers, designers, and architects can use this conceptualization and index to closely monitor and measure for evaluations and further improvements of the MHS, thereby enhancing patient experience in maternity wards.
Biological Effects of High Tibial Osteotomy on Spontaneous Osteonecrosis of the Knee
Authors: Kumagai Ken , Yamada Shunsuke , Nejima Shuntaro , Sotozawa Masaichi , Inaba Yutaka 
Published: August 2022

Objective The purpose of this study was to evaluate the postoperative status of spontaneous osteonecrosis of the knee (SONK) after high tibial osteotomy (HTO) with concomitant bone marrow stimulation (BMS) using synovial fluid (SF) biomarkers. Design Twenty patients with SONK who underwent opening wedge HTO were enrolled. Paired SF samples from the affected knee were collected at the time of HTO surgery and at the time of plate removal. SF concentrations of interleukin (IL)-6, IL-8, and matrix metalloproteinase (MMP)-13 were measured by enzyme-linked immunosorbent assays. The Knee Society Score (KSS) and hip-knee-ankle (HKA) angle were assessed before and 2 years after HTO. Results The KSS knee and function scores were significantly improved after HTO (mean changes of 33.8 and 29.4, respectively). The mean HKA angle was changed from mechanical varus (−8.6°) to valgus (5.2°). Concentrations of IL-6, IL-8, and MMP-13 were significantly decreased after HTO (mean changes of −73.7%, −32.4%, and −47.9% from preoperative baseline, respectively). Significant correlations were found between lesion size and concentrations of biomarkers, except for preoperative MMP-13. Conclusions SF levels of biomarkers of inflammation and cartilage degradation were reduced after HTO with a concomitant BMS procedure, suggesting a biological improvement in SONK.
Prevalence and global trends of polypharmacy among people living with HIV: a systematic review and meta-analysis
Authors: Danjuma Mohammed I. , Adegboye Oyelola A. , Aboughalia Ahmed , Soliman Nada , Almishal Ruba , Abdul Haseeb , Mohamed Mohamad Faisal Hamad , Elshafie Mohamed Nabil , AlKhal Abdulatif , Elzouki Abdelnaser , Al-Saud Arwa , Chaponda Mas , Bidmos Mubarak Arriyo 
Published: August 2022

Background: There has been a rising prevalence of polypharmacy among people living with HIV (PLWH). Uncertainty however remains regarding the exact estimates of polypharmacy among these cohorts of patients. Methods: We conducted a systematic search of PubMed; EMBASE, CROI, Cochrane Database of Systematic Reviews; Science Citation Index and Database of Abstracts of Reviews of Effects for studies between 1 January 2000 and 30 June 2021 that reported on the prevalence of polypharmacy (ingestion of > 5 non-ART medications) among PLWH on antiretroviral therapy regimen (ART). Prevalence of polypharmacy among HIV-positive patients on ART with Clopper–Pearson 95% confidence intervals were presented. The heterogeneity between studies was evaluated using [Formula: see text] and [Formula: see text] statistics. Results: One hundred ninety-seven studies were initially identified, 23 met the inclusion criteria enrolling 55,988 PLWH, of which 76.7% [95% confidence interval (CI): 76.4–77.1] were male. The overall pooled prevalence of polypharmacy among PLWH was 33% (95% CI: 25–42%) ( I2 = 100%, τ2 = 0.9170, p < 0.0001). Prevalence of polypharmacy is higher in the Americas (44%, 95% CI: 27–63%) ( I2 = 100%, τ2 = 1.0886, p < 0.01) than Europe (29%, 95% CI: 20–40%) ( I2 = 100%, τ2 = 0.7944, p < 0.01). Conclusion: The pooled prevalence estimates from this synthesis established that polypharmacy is a significant and rising problem among PLWH. The exact interventions that are likely to significantly mitigate its effect remain uncertain and will need exploration by future prospective and systematic studies. Registration: PROSPERO: CRD42020170071 Plain Language Summary Background: In people living with HIV (PLWH), what is the prevalence of polypharmacy and is this influenced by sociodemographic factors? Methods and Results: In this systematic review and meta-analysis of 23 studies comprising 55,988 participants, we have for the first time found an estimated polypharmacy pooled prevalence of 33% among PLWH. There was a relatively higher pooled prevalence of polypharmacy among the America’s compared with European cohorts of PLWH. Conclusion: Polypharmacy among PLWH is a rising morbidity that needs urgent intervention both at policy and patient levels of care.
Patient experiences of remote care in a pain service during a pandemic
Authors: Willcocks Cathy , Joy Deborah LA , Seward Joseph , Mills Samantha , Heywood Mark , Price Cathy 
Published: August 2022

Background In March 2020, Pain Management Services were obliged to cease face-to-face consultations. This abrupt change, in line with recommendations from the British Pain Society, aimed to protect patients and staff and allowed resource re-allocation. Pain services were obliged to switch to remote consultations using Video Tele-Conferencing Technology (VTC) and Remote Consultations (RC) either through telephone or video calls using a variety of media and software applications. Little is known about the patient experience of remotely delivered pain care especially when alternatives are removed. The aim of this work was to understand the patient experience of this necessary switch regarding pain self-management interventions during the initial stages of the COVID-19 pandemic. Methods A mixed-methods evaluation of the patient experience from three pain self-management interventions, taking place in a large community-based pain rehabilitation service along the South Coast of England, was performed. Experience-Based Design (EBD) methods were used to map patient experience at touch points through two interventions that were delivered in a structured format. Semi-structured recorded interviews were transcribed and analysed using thematic analysis for the third. Findings Fifty-eight patients took part covering the scope of the service. In general, educational and psychological sessions were well received, with physical rehabilitation components being less easy to convey remotely. Attrition rates were high for the pain management programme. Group pain education worked particularly well in an online format with hope being the predominant emotion experienced. Clear limitations were technical failures and the lack of ability to form relationships in a virtual world. Conclusions Remote digitalised interventions were acceptable to most patients. Attention should be paid to access and improving social aspects of delivery when considering such interventions. Physiotherapy may require more face-to-face necessitating a hybrid model and needs further investigation. EBD proved a highly suitable approach.
Complications After Percutaneous Osteotomies of the Calcaneus
Authors: deMeireles Alirio J. , Guzman Javier Z. , Nordio Andrea , Chan Jimmy , Okewunmi Jeffrey , Vulcano Ettore 
Published: August 2022

Background: Open hindfoot surgery is associated with a relatively high rate of complications, including neurovascular injuries and wound healing problems compared with percutaneous techniques. However, there is a scarcity of literature describing the outcomes of these percutaneous techniques given their relatively recent adoption. The present study aims to assess the rate of postoperative complications for 3 commonly performed percutaneous calcaneal osteotomies. Methods: One hundred eighteen patients (unilateral feet) were treated with one of 3 common percutaneous calcaneal osteotomies. Sixty-five patients (55.1%) were treated with a medializing calcaneal osteotomy for hindfoot valgus, 32 patients with a Zadek osteotomy (27.1%) for insertional Achilles tendinopathy, and 21 patients (17.8%) with a modified Dwyer osteotomy for hindfoot varus. Fisher exact test was used to assess for associations between categorical variables. Results: The mean age was 46.2 years and there was a mean follow-up of 16.1 months. The overall rate of postoperative complications was 3.4% (n = 4), and no significant differences were found between the different osteotomy types. Complications included 2 cases (1.7%) of transient neuritis, 1 case of prolonged wound drainage (0.8%), and 1 nonunion (0.8%). None of the complications were associated with any recorded preoperative comorbidity. Discussion: In this series, we found that percutaneous calcaneal osteotomies are a safe alternative method for the treatment of conditions involving the hindfoot. The rate of postoperative complications may be less when compared to the reported rates of open hindfoot correction and should be considered in patients with a traditionally high risk of developing a postoperative complication. Level of Evidence: Level IV, retrospective analysis.
Wire Arc Additive Manufactured CuMn13Al7 High-Manganese Aluminium Bronze
Authors: Guo Chun , Hu Baisong , Wei Baoli , Chen Feng 
Published: August 2022

AbstractIn this work, high-manganese aluminium bronze CuMn13Al7 samples were prepared by arc additive manufacturing technology. The phase composition, microstructure, and crystal structure of the high-manganese aluminium bronze CuMn13Al7 arc additive manufactured samples were analysed using direct-reading spectrometer, metallographic microscope, scanning electron microscope, and transmission electron microscope. The micro-hardness tester, tensile tester, impact tester, and electrochemical workstation were also used to test the performance of the CuMn13Al7 samples. By studying the microstructure and properties of the CuMn13Al7 samples, it was found that preparation of the samples by the arc additive manufacturing technology ensured good forming quality, almost no defects, and good metallurgical bonding inside the sample. The metallographic structure (α + β + point phase) mainly comprises the following: the metallographic structure in the equiaxed grain region has an obvious grain boundary α; the metallographic structure in the remelting region has no obvious grain boundary α; the thermal influence on the metallographic structure produced a weaker grain boundary α than the equiaxed grain region. The transverse and longitudinal cross sections of the sample had uniform microhardness distributions, and the average microhardness values were 190.5 HV0.1 and 192.7 HV0.1, respectively. The sample also had excellent mechanical properties: yield strength of 301 MPa, tensile strength of 633 MPa, elongation of 43.5%, reduction of area by 58%, Charpy impact value of 68 J/cm2 at – 20 ℃, and dynamic potential polarisation curve test results. Further, it was shown that the average corrosion potential of the sample was – 284.5 mV, and the average corrosion current density was 4.1×10–3 mA/cm2.
Spontaneous Exciton Collapse in a Strongly Flattened Ellipsoidal InSb Quantum Dot
Authors: Dvoyan K. G. , Karoui A. , Vlahovic B. 
Published: August 2022

AbstractElectronic and excitonic states in an InSb strongly flattened ellipsoidal quantum dot (QD) with complicated dispersion law are theoretically investigated within the framework of the geometric adiabatic approximation in the strong, intermediate, and weak quantum confinement regimes. For the lower levels of the spectrum, the square root dependence of energy on QD sizes is revealed in the case of Kane’s dispersion law. The obtained results are compared to the case of a parabolic (standard) dispersion law of charge carriers. The possibility of the accidental exciton instability is revealed for the intermediate quantum confinement regime. For the weak quantum confinement regime, the motion of the exciton's center-of-gravity is quantized, which leads to the appearance of additional Coulomb-like sub-levels. It is revealed that in the case of the Kane dispersion law, the Coulomb levels shift into the depth of the forbidden band gap, moving away from the quantum confined level, whereas in the case of the parabolic dispersion law, the opposite picture is observed. The corresponding selection rules of quantum transitions for the interband absorption of light are obtained. New selection rules of quantum transitions between levels conditioned by 2D exciton center of mass vertical motion quantization in a QD are revealed. The absorption threshold behavior characteristics depending on the QDs geometrical sizes are also revealed.
Protein structure prediction based on particle swarm optimization and tabu search strategy
Authors: Shuchun Yu , Xianxiang Li , Xue Tian , Ming Pang 
Published: August 2022

Abstract
Background
The stability of protein sequence structure plays an important role in the prevention and treatment of diseases.

Results
In this paper, particle swarm optimization and tabu search are combined to propose a new method for protein structure prediction. The experimental results show that: for four groups of artificial protein sequences with different lengths, this method obtains the lowest potential energy value and stable structure prediction results, and the effect is obviously better than the other two comparison methods. Taking the first group of protein sequences as an example, our method improves the prediction of minimum potential energy by 127% and 7% respectively.

Conclusions
Therefore, the method proposed in this paper is more suitable for the prediction of protein structural stability.