bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early removal of a permanent catheter during the acute management of the unstable pediatric hemato-oncology patient with suspected catheter-related bloodstream infection: a multi-disciplinary survey and review of the literature
Authors: Cohen Neta , Rosenberg Tom , Rimon Ayelet 
Published: October 2022

Abstract
Purpose
There are no guidelines for the optimal manner and timing of permanent central catheter removal in the hemodynamically unstable pediatric hemato-oncology patient with suspected catheter related bloodstream infections (CRBSI). Our goals were to examine current practices of permanent central catheter management and choice of removal in the hemodynamically unstable pediatric patient with suspected CRBSI among practitioners in diverse subspecialties.
Methods
We performed a literature review on the subject, and conducted a multi-disciplinary survey included pediatric oncologists, pediatric emergency medicine physicians, and pediatric intensive care physicians whom we queried about their choice of permanent central catheter management and removal while treating the hemodynamically unstable pediatric patient with suspected CRBSI.
Results
Most of the 78 responders (n = 47, 59%) preferred to utilize the existing permanent central catheter for initial intravenous access rather than an alternative access. There were no significant differences between physician subspecialties (p = 0.29) or training levels (p = 0.14). Significantly more pediatric emergency medicine physicians preferred not to remove the permanent central catheter at any time point compared to the pediatric hemato-oncologists, who preferred to remove it at some point during the acute presentation (44.4% vs. 9.4%, respectively, p = 0.02).
Conclusions
Our study findings reflect the need for uniform guidelines on permanent central catheter use and indications for its removal in the hemodynamically unstable pediatric patient. We suggest that permanent central catheter removal should be urgently considered in a deteriorating patient who failed to be stabilized with medical treatment.
Recovery-Model: a model for CAR T-cell-related thrombocytopenia in relapsed/refractory Multiple myeloma
Authors: Li Zhe , Que Yimei , Wang Di , Lu Jie , Li Chunhui , Xu Menglei , Wang Zhiqiong , Yu Qiuxia , Long Xiaolu , An Ning , Xiao Yi , Li Chunrui 
Published: October 2022

Abstract
Background: Multiple myeloma (MM) patients treated with anti-BCMA chimeric antigen receptor (CAR) T-cell therapy tend to have delayed platelet recovery
Patients and methods: This was a single-center retrospective observational study, which included a cohort of MM patients treated with anti-BCMA CAR-T in ChiCTR-OPC-16009113, ChiCTR1800018137, and ChiCTR1900021153.
Results: 58 MM patients treated with anti-BCMA CAR-T were included, and delayed platelet recovery (platelet not recovered to 50×109 /L within 28 days) could be observed in 36% of patients. The regression analysis identified factors influencing platelet recovery such as baseline platelet counts (p < 0.0001, r = -0.59) and the Recovery-Model was created. High Recovery- Model score indicated a greater risk of delayed platelet recovery after CAR-T infusion and reflected the risk of hematologic toxicity. Predictive biomarkers of the model included baseline platelet count, baseline hemoglobin, logarithm of baseline ferritin, and cytokine release syndrome grade. Finally, survival analysis showed the significant relationship between overall survival, delayed platelet recovery (p = 0.0457) and a high Recovery-Model score (P = 0.0011).
Conclusions: Inflammation-related factors and hematopoietic reserve were associated with delayed platelet recovery. We developed a model to predict the risk of platelet recovery and hematological toxicity in R/R MM patients after anti-BCMA CAR-T treatment.
One-pot synthesis of indole-fused diketopiperazine through an Ugi 4-CR condensation and N-annulation under mild conditions
Authors: Shourkaei Fatemeh Ahmadi , Ranjbar Parviz Rashidi , mahdavi mohammad 
Published: October 2022

Abstract
This communication describes two-step approach to the synthesis of indole-fused diketopiperazine derivatives based on no metal catalyst cyclization of the Ugi adducts in the presence of trimethylamine. The reaction was initiated by simple Ugi condensation, followed by nucleophilic intramolecular attack in one-pot under mild conditions. This report is an excellent strategy for the preparation of new biological compounds containing indole-fused diketopiperazine
Penalized Model-based Clustering of Complex Functional Data
Authors: Pronello Nicola , Ignaccolo Rosaria , Ippoliti Luigi , Fontanella Sara 
Published: October 2022

Abstract
High dimensional data, large-scale data, imaging and manifold data are all fostering new frontiers of statistics. These type of data are commonly considered in Functional Data Analysis (FDA) where they are viewed as infinite-dimensional random vectors in a functional space. The rapid development of new technologies has generated a flow of complex data that have led to the development of new modeling strategies by scientists. In this paper, we basically deal with the problem of clustering a set of complex functional data into homogeneous groups. Working in a mixture model-based framework, we develop a flexible clustering technique achieving dimensionality reduction schemes through an L1 penalization. The proposed procedure results in an integrated modelling approach where shrinkage techniques are applied to enable sparse solutions in both the means and the covariance matrices of the mixture components, while preserving the underlying clustering structure. This leads to an entirely data-driven methodology suitable for simultaneous dimensionality reduction and clustering. The proposed methodology is evaluated through a Monte Carlo simulation study and an empirical analysis of real-world datasets showing different degrees of complexity.
Novel markers to evaluate the disease activity of rheumatoid arthritis based on some intestinal flora imbalance, abnormal immune cells and cytokines
Authors: Chi shuhong , Jiang chunlei , Wang fengkui , Wu lihua , Yang xiaojuan , Liu miao , Ma bin , Ubaid Syed , Su chunxia , Duan xiangguo 
Published: October 2022

Abstract
Objective: We aimed to investigate the changes of gut microbiota and analyze the correlation of gut microbiota with lymphocyte subsets, cytokines and clinical indicators in RA patients with active and remission stage, and to find new makers to evaluate disease activity of RA.
Method: The intestinal flora of subjects was collected for 16SrRNA gene sequencing. Flow cytometry to detect the number of lymphocyte subsets and their ability to secrete cytokines. ELISA was used to test the serum levels of cytokines.
Result: The richness and diversity of gut microbiota were significantly decreased in active and remission stages of RA patients compared to HCs. Most importantly, at the phylum level, the relative abundance of Bacteroidetes and Actinobacteria was decreased in RA patients with remission stage, while the relative abundance of Fusobacteria was increased in RA patients with active compared to HCs. At the genus level, the relative abundance of Ruminococcaceae_Ruminococcus and Bacteroides was decreased, while the abundance of Megamonas was increased in RA patients with active and remission stage compared to HCs. Intestinal flora was directly correlated with lymphocytes, cytokines and clinical indicators in active and remission stages of RA patients.
Conclusion: These results suggest that the changes of gut microbiota can lead to imbalances of CD4+T, CD8+T, memory B-cell subsets and cytokines that influence disease activity of RA patients. Interestingly, some intestinal flora may be used as markers to evaluate disease activity in RA patients.
Factors affecting the total occlusion time in eyes with hyperopic anisometropic amblyopia
Authors: Utamura Keisuke , Wakayama Akemi , Matsumoto Fumiko , Shiraishi Yukari , Narita Ikumi , Tanabe Fumi , Kusaka Shunji 
Published: October 2022

Abstract
Purpose To investigate the factors that affected the total occlusion time (TOT) in eyes with hyperopic anisometropic amblyopia.
Methods Subjects were 58 patients (26 boys and 32 girls; age range, 3.6-9.2, average, 5.8 ± 1.3 years) with hyperopic anisometropic amblyopia. All the subjects had initially visited and completed occlusion therapy with improved visual acuity (VA) of 1.0 (0.0 logMAR equivalent) or better in the amblyopic eye at Kindai University Hospital between January 2007 and March 2017. Using the subjects’ medical records, five factors for the TOT were evaluated retrospectively: the age at treatment, the initial VA of the amblyopic eye, refraction of the amblyopic eye, anisometropic disparity, and the presence of microstrabismus.
Results The initial VA of the amblyopic eye ranged from 0.1 to 0.9 (median, 0.4). The TOT ranged from 140 to 1795 (median, 598) hours with an average daily occlusion time of 7 hours. The initial VA of the amblyopic eye and presence of microstrabismus were the influential factors for the TOT (p< 0.01). To achieve VA of 1.0 or better, patients with initial VA of ≤ 0.3 in the amblyopic eye required a longer TOT. Moreover, patients with concomitant microstrabismus required a 1.7-fold longer TOT compared to those without microstrabismus.
Conclusion Patient’s initial VA and the presence of microstrabismus are the significant factors that affect the TOT.
Characterizations of derivations on spaces of smooth functions
Authors: Fechner Włodzimierz , Świątczak Aleksandra 
Published: October 2022

Abstract
We provide a list of equivalent conditions under which an additive operator acting on a space of smooth functions on a compact real interval is a multiple of the derivation.
Mathematics Subject Classification (2010). Primary: 39B42; Secondary: 39B72, 39B82, 47B47.
Effect of fidget spinners in enhancement of cognitive skills in healthy individuals: An interventional study
Authors: Biswas Ratnadeep , Kumar Yogesh , Rani Ruchi 
Published: October 2022

Abstract
Introduction
Fidget spinners have gained explosive popularity. Polarizing anecdotal accounts of their effects have been given but very few studies have been conducted to assess their effect. Thus, this study was undertaken to observe the effect of using fidget spinners on various aspects of cognition.
Methods
We selected 30 healthy individuals and following the recording of baseline scores in various cognitive function tests, they took these tests before & after a particular intervention (i.e., using fidget spinners) daily for a total of 9 days over the course of three weeks, at the end of which, an end-assessment was done. A follow-up was conducted after a period of 3 weeks post-discontinuation of fidget spinners.
Results
Significant improvement was observed in digit symbol matching, picture pairs, multiple object tracking, and fast choice tests (p < 0.001). A sustained effect was observed when the follow-up scores were compared to baseline and end-assessment scores.
Conclusion
While there was little to no change in fluid intelligence and response speed, using fidget spinners resulted in sustained improvement in processing speed, visual episodic memory, working memory, visuospatial attention, and inhibitory control. Regular use of fidget spinners might improve various aspects of cognition and benefit countless individuals.
Early experience of adopting a generative diffusion model for the synthesis of fundus photographs
Authors: Yoo Tae Keun , Ryu Ik Hee , Kim Hong Kyu 
Published: October 2022

Abstract

The generative diffusion model has been highlighted as a state-of-the-art artificial intelligence technique for image synthesis. Here, we show that a denoising diffusion probabilistic model (DDPM), which is currently a popular diffusion technique, can be used for a domain-specific task generating fundus photographs. Because the DDPM has disadvantages, including difficulty in training and low image quality compared with generative adversarial networks, further studies are needed to improve diffusion models.
Assessment of COVID-19 vaccines side effects among Health workers in Damascus Hospital: cross-sectional study
Authors: Bibars Marwa , alikhtyar Abdullatif , Al-bardan Hossam 
Published: October 2022

Abstract
Background
Severe Acute Respiratory Syndrome Coronavirus 2 continues to spread in the world, and in the absence of an effective treatment, the vaccine remains the best hope for controlling this disease. In this study, we seek to evaluate the side effects of vaccines among health workers in Damascus Hospital.
Methods
A cross-sectional study was conducted among health sector workers at Al-Mujtahid Hospital in Damascus using an appropriate sampling pattern. Written informed consent was obtained from all participants. A self-administered, paper-based, self-filling questionnaire that has been used in previous studies. The study included 299 participants from employees, students or students who had previously received the corona vaccine. Ethical approval was obtained from the Institutional Review Board (IRB), Faculty of Medicine, Syrian Private University.
Results
Out of the 299 participants, 54.5% were male and 45.5% were female. With an average age of 26.7 years. 61.9% of the participants stated that they had taken the vaccine in its complete program with two doses, and 24.4% had taken the vaccine in its complete program with its single dose only. Most of the participants received the vaccine inside Syria (96.3%). Pain at the injection site was the most prominent symptom, especially after receiving the first dose of the vaccine. 44.8% of the participants had mild side effects, while 40.1% of the participants reported having moderate side effects. Most of those who received the Sputnik vaccine showed 38.1% mild side effects. Notable against the rest of the types of vaccines, most of those who received another vaccine (Pfizer, Moderna or Johnson) had greater side effects compared to the rest of the vaccines provided in the hospital, namely Sputnik, Sinopharm and AstraZeneca.
Conclusion
This study revealed that nearly all the side effects that occurred were similar to those reported in the literature, indicating that most COVID-19 vaccines` side effects are almost known at this time. The majority of them are non-life threatening, with most cases being mild to moderate in intensity and resolving in a few days. statistically significant between the type of vaccine and the various side effects. More comprehensive studies should be conducted and others also to investigate the possible causes.
Road extraction based on dynamic scale MSR and improved Canny in vague aerial images
Authors: wang w , Feng Sheng , Tu Angyan 
Published: October 2022

Abstract
Road extraction in vague aerial or remote sensing images is hard but significant. In this paper, a road extraction method for vague aerial images is studied. The method consists of four main algorithms: (1) a modified MSR algorithm to enhance a vague aerial road image, in which, the logarithm transform is applied first, then the scales for Retinex are determined in light on the image depth by using the method of dark channel prior; (2) the enhanced image is roughly segmented based on the improved Canny edge detector with edge region expansion, then, edge image is thresholded by Otsu; (3) a number of post processing functions in a binary image is applied for gap linking and noise removal; and (4) the extracted roads are regulated by using the road shape features. In experiments, a number of vague aerial images of multiple roads were selected, and the algorithm comparison results show that the studied method is satisfactory for the road extraction in a vague aerial image, and it is much better than other traditional algorithms.
KMnO4 modified biochar derived from swine manure for tetracycline removal
Authors: Fu Zan , Chen Yurong , Lu Yanyan , Wang Yue , Chen Jiahui , Zhao Youxin , Yang Mengya , Tian Xiaofei 
Published: October 2022

Abstract
Tetracycline (TC) is widely used in the livestock industry, but undigested TC is excreted with livestock waste and accumulates in the environment. In this study, swine manure-derived biochar (SBC) was modified with KMnO4 (MnOx-SBC), and used to remove TC. SEM-EDS, FTIR, XPS and elemental analysis all indicated that ultrafine MnOx particles were attached to the biochar surface. The surface properties and composition of the oxygen-containing functional groups were enhanced by KMnO4 modification. Batch sorption experiments showed that MnOx-SBC's TC-adsorption capacity was 105.9 mg·g−1, 46.4% higher than SBC's. The TC-adsorption onto MnOx-SBC agreed well with the pseudo-second-order model and Freundlich isotherm. A new platform is proposed for reusing swine manure while solving the livestock industry's antibiotic pollution risk by ‘treating waste with waste’.
Inhibitors of Tyrosine Kinases Involved in Inflammation and Autoimmune Disease
Authors: Myers Michael R. , He Wei , Hulme Christopher 
Published: October 2022

Abstract:
The study of tyrosine kinases involved in cellular signaling associated with inflammation and autoimmune disease is rapidly progressing. Lessons learned from recent successes in identifying novel, potent, and selective tyrosine kinase inhibitors for the treatment of cancer and cardiovascular disease can be applied toward developing selective tyrosine kinase inhibitors for targets associated with diseases such as rheumatoid arthritis, sepsis and autoimmune disease. The design of new selective tyrosine kinase inhibitors will be aided by the very recent successes in solving X-ray crystal structures of
the catalytic domains of several kinases. This paper summarizes the literature on inhibitors of several non- receptor and receptor tyrosine kinases thought to be involved in cellular signaling associated with infl_ammatory diseases.
State-of-the-art Tools to Elucidate the Therapeutic Potential of TAT-peptide (TP) Conjugated Repurposing Drug Against SARS-CoV-2 Spike Glycoproteins
Authors: Ansari Mohammad Azam , Alomary Mohammad N. , Jamal Qazi Mohammad Sajid , Almoshari Yosif , Salawi Ahmed , Almahmoud Suliman A. , Khan Johra 
Published: October 2022

Background:In late 2019, a highly infectious and pathogenic coronavirus was recognized as Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), which causes acute respiratory disease, threatening human health and public safety. A total of 448,327,303 documented cases and 6,028,576 deaths have been reported as of March 8th 2022. The COVID-19 vaccines currently undergoing clinical trials or already in use should provide at least some protection against SARS-CoV-2; however, the emergence of new variations as a result of mutations may lessen the effectiveness of the currently available vaccines. Since the efficacy of available drugs and vaccines against COVID-19 is notably lower, there is an urgent need to develop a potential drug to treat this deadly disease. The SARS-CoV-2 spike (SCoV-SG) is the foremost drug target among coronaviruses.ObjectiveL:The major objectives of the current study are to conduct a molecular docking study investigation of TAT-peptide47–57(GRKKRRQRRRP)-conjugated remodified therapeutics such as ritonavir (RTV), lopinavir (LPV), favipiravir (FPV), remdesivir (RMV), hydroxychloroquine (HCQ), molnupiravir (MNV) and nirmatrelvir (NMV) with (SCoV-SG) structure.Methods:Molecular docking analysis was performed to study the interaction of repurposed drugs and drugs conjugated with the TAT-peptide with target SARS-CoV-2 spike glycoprotein (PDB ID: 6VYB) using Auto- Dock. Further docking investigation was completed with PatchDock and was visualized by the discovery of the studio visualizer 2020.Results:TAT-peptides are well-characterized immune enhancers that are used in intracellular drug delivery. The results of molecular docking analysis showed higher efficiency and significantly enhanced and improved interactions between TP-conjugated repurposed drugs and the target sites of the SCoV-SG structure.Conclusion:The study concluded that TP-conjugated repurposed drugs may be effective in preventing COVID- 19, and therefore, in vitro, in vivo, and clinical trial studies are required in detail.
Advances in Exercise Therapy in Hemodialysis: A Systematic Review
Authors: Li Yu , Wang Xin , Pei Zuowei 
Published: October 2022

Background:
The main and common treatment of renal replacement therapy (RRT) for
chronic kidney disease (CKD), especially in end-stage kidney disease (ESKD) patients, is hemodialysis
(HD). Many reports have shown that exercise therapy is good for HD patients. This review aims to
describe recent advances in exercise therapy in HD patients.

Objective:
Our key opinions have focused on varied types of exercise therapy and identified barriers
to exercise therapy among HD patients. Exercise implementation includes aerobic exercise training,
resistance exercise training, combined exercise training, and novel exercise interventions. Barriers
include internal and external distress, such as HD patients' restrictions and environmental problems.

Methods:
This review is based on the novel/ most findings in PubMed, Web of Science, Google
Scholar, and MEDLINE from the inception of every database until August 2022.

Results:
The systematic search strategy identified 6 articles that met the inclusion criteria. Four were
specific to exercise therapy in HD, and three were to exercise barriers in HD. Massive evidence has
demonstrated exercise therapy for HD has specific benefits and neglectful causes of exercise barriers.

Conclusion:
In this review, we aimed to summarize recent advances in individual exercise therapy
recommendations (type, intensity, time, and frequency) and exercise barriers in HD patients. In conclusion,
Low/moderate-intensity exercise trained for at least thirty minutes five times per week, including
aerobic exercise (Walking, Jogging, Swimming, and Health Exercises), resistance training
(Dumbbells, Band training, and Knee extension), and combination exercise (both) during the first 2
hours of dialysis treatment or non-dialysis days is advisable treatment recommendation.
A Review on Proniosomes: A Propitious Outlook to the Provesicular Drug
Delivery System
Authors: Saxena Anamika , Apurvi Pragya , Aslam Ramsha 
Published: October 2022

Abstract:
Currently, various kinds of research are going in the evolution of the Novel Drug Delivery
System. NDDS mainly emphasizes the development of a system with improved sustained, controlled,
and targeted drug delivery with minimum toxicity. Proniosomes are dry free-flowing formulation that
minimizes the drawbacks associated with liposomes and niosomes. Proniosomes are carrier particles
that are water-soluble and covered with a surfactant which, upon hydration in a hot aqueous medium
with agitation, gives niosomal dispersion. Proniosomes derived niosomes are superior substitutes as
compared to other vesicular delivery due to preferable physicochemical properties and improved chemical
stability. The proniosomes deliver additional convenience of transportation, storage, distribution,
and dosing, which makes dry niosomes a versatile commercial product. This illustrated review emphasizes
the components, method of preparation, factors affecting the formation of proniosomes, characterization,
and various routes of administration of proniosomes. This review will help to explore the efficacy
and functionality of proniosomes in different fields for their upcoming supremacy in the field of drug
delivery.