bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avoiding the news to participate in society? The longitudinal relationship between news avoidance and civic engagement
Authors: Ohme Jakob , Bruin Kiki de , Haan Yael de , Kruikemeier Sanne , Meer Toni G.L.A. van der , Vliegenthart Rens 
Published: June 2022

Abstract
Lower levels of news use are generally understood to be associated with less political engagement among citizens. But while some people simply have a low preference for news, others avoid the news intentionally. So far little is known about the relationship between active news avoidance and civic engagement in society, a void this study has set out to fill. Based on a four-wave general population panel survey in the Netherlands, conducted between April and July 2020 (N = 1,084) during a crisis situation, this research-in-brief investigates the development of news avoidance and pro-social civic engagement over time. Results suggest that higher news topic avoidance results in higher levels of civic engagement. The study discusses different explanations for why less news can mean more engagement.
Supervision method of indoor construction engineering quality acceptance based on cloud computing
Authors: Zhang Jian 
Published: June 2022

Abstract
As an important part of Chinese economy, the construction industry has a great contribution to the economy, and plays an important role in the Chinese economic development. Therefore, it has certain research significance for the quality acceptance supervision method of construction engineering. This article takes Shenzhen S project as an example, combined with cloud computing, discusses the quality acceptance and supervision methods of indoor construction projects. In the introduction to the technical part, this article first briefly introduces the definition of cloud computing and then introduces the particle swarm algorithm and traditional genetic algorithm in the cloud computing task scheduling method. The algorithm is introduced into the quality acceptance of indoor construction projects to obtain the quality, most efficient method for acceptance supervision. The experimental part of this article takes S project as the research object and the residents’ satisfaction with the project as the experimental purpose. Finally, through statistical analysis, it is concluded that the residents’ satisfaction with S project reaches more than 70%.
Ein neuartiges Konzept für 5D Nanopositionier-, Nanomess-,und Nanofabrikationsmaschinen
Authors: Leineweber Johannes , Meyer Christoph , Füßl Roland , Theska René , Manske Eberhard 
Published: June 2022

Zusammenfassung
In den vergangenen Jahren wurden an der TU-Ilmenau zahlreiche Entwicklungen im Bereich der Nanopositionier- und Nanomesstechnik realisiert. Insbesondere die NMM-1 [Gerd Jäger, Eberhard Manske, Tino Hausotte, Jans-Joachim Büchner, Nanomessmaschine zur abbefehlerfreien Koordinatenmessung, tm – Technisches Messen, 67(7–8), 2000] sowie die NPMM-200 [Eberhard Manske, Gerd Jäger, Tino Hausotte, Felix Balzer, Nanopositioning and Nanomeasuring Machine NPMM-200 – sub-nanometre resolu-tion and highest accuracy in extended macroscopic working areas, euspen’s 17th International Conference, 2017] stellen ein Novum auf dem Gebiet der Koordinatenmesstechnik mit Nanometerpräzision unter Einhaltung des Abbe-Komparatorprinzips [Ernst Abbe, Messaparate für Physiker, Zeitschrift für Instrumentenkunde, 10:446–448, 1890] dar. Ausgehend von diesen Errungenschaften besteht ein nächster Schritt im Messen und Fabrizieren auf stark gekrümmten, asphärischen, oder freigeformten Oberflächen. Vor jenem Hintergrund wird im folgenden Artikel ein Konzept für ein zweiachsiges Rotationsmodul vorgestellt. Dieses dient als Erweiterung für die NMM-1 und ermöglicht über das kartesische Messvolumen von

25

mm
×
25

mm
×
5

mm

25\hspace{0.1667em}\text{mm}\times 25\hspace{0.1667em}\text{mm}\times 5\hspace{0.1667em}\text{mm}

hinaus zusätzlich eine Rotation des Tools über 360 ° um die Hochachse sowie 60 ° Neigung. Die Umsetzung erfolgt über eine neuartige sphärische Parallelkinematik. Mit Hilfe eines interferometrischen In-Situ-Referenzmesssystems können die während der Rotationsbewegungen auftretenden translatorischen Positionsabweichungen detektiert werden. Erste Untersuchungen an einem Prototypenaufbau erbringen den Funktionsnachweis des Referenzmesssystems über den gesamten adressierbaren Winkelbereich.
Die nichtfinanzielle Berichterstattung – Analyse der Herausstellungsmöglichkeiten von Genossenschaftsbanken und Sparkassen und das Vorgehen in der Berichtspraxis
Authors: Helms Nils 
Published: June 2022

Zusammenfassung
Die nichtfinanzielle Berichterstattung, oftmals auch als Nachhaltigkeitsberichterstattung bezeichnet, gewinnt immer größere Bedeutung im Rahmen der Unternehmensberichterstattung. Zielsetzung des Beitrags ist die Analyse, inwieweit Genossenschaftsbanken und Sparkassen in ihrer nichtfinanziellen Berichterstattung ihre Alleinstellungsmerkmale, die eindeutige Nachhaltigkeitsbezüge aufweisen, herausarbeiten. Um dies empirisch überprüfen zu können, werden zunächst Kriterien zur Herausstellung der Spezifika abgeleitet, die dann mit Hilfe einer qualitativen Inhaltsanalyse ausgewertet werden. Im Ergebnis zeigt sich, dass sowohl die Genossenschaftsbanken als auch die Sparkassen ihre Besonderheiten hinsichtlich der Nachhaltigkeit hervorheben, aber in einigen Themengebieten (z. B. lokale Aktivitäten, Mitbestimmung) eine noch stärkere Herausarbeitung möglich wäre.
Primary adrenal insufficiency in a patient with biallelic QRSL1 mutations
Authors: Dursun Fatma , Genc Hulya Maras , Mine Yılmaz Ayşe , Tas Ibrahim , Eser Metin , Pehlivanoglu Cemile , Yilmaz Betul Karademir , Guran Tulay 
Published: June 2022

Background
Biallelic QRSL1 mutations cause mitochondrial ‘combined oxidative phosphorylation deficiency-40’ (COXPD40). COXPD40 has been reported to be invariably lethal in infancy. Adrenal insufficiency was weakly reported and investigated among seven previously reported patients with COXPD40.

Objective
We report the clinical, biochemical, molecular, and functional characteristics of a patient with adrenal insufficiency due to COXPD40.

Methods
The medical history and adrenal function tests were examined. Genetic analysis was performed using whole-exome sequencing. Mitochondrial function was tested using mitochondrial membrane potential (MMP) and superoxide dismutase (SOD) enzyme assays.

Results
An 8-year-old boy was investigated for adrenal insufficiency. He also had mild developmental delay, sensorineural hearing loss, hypertrophic cardiomyopathy, nephrocalcinosis, elevated parathyroid hormone and creatine kinase, and lactic acidosis. Biallelic novel QRSL1 variants (c.300T>A;Y100* and c.610G>A;G204R) were identified. Oxidative damage in mitochondria was shown by reduced MMP and SOD assays in the patient compared to controls (P < 0.0001). Adrenal function tests revealed a ‘primary adrenal insufficiency other than congenital adrenal hyperplasia’ (non-CAH PAI) with an isolated glucocorticoid deficiency. In the 8-year follow-up, having the longest survival of reported COXPD40 patients, he had preserved mineralocorticoid functions and gonadal steroidogenesis.

Conclusion
Biallelic QRSL1 mutations can cause non-CAH PAI. Adrenal functions should be monitored in mitochondrial disorders to improve clinical outcomes.
How Routine are Routine Vital Signs?
Authors: McDaniel Lauren M. , Ralston Shawn L. 
Published: June 2022

BACKGROUND AND OBJECTIVES
Frequent measurement of vital signs has been associated with disruptions to sleep and increased nursing workload. Since vital signs are often measured at the same frequency regardless of patient acuity, there may be inappropriate prioritization of limited resources. We sought to understand what hospitalists report as the default frequency of routine vital sign measurement in hospitalized pediatric patients at academic institutions.

METHODS
We surveyed pediatric hospital medicine leadership at Association of American Medical Colleges-affiliated medical schools on their perception of routine vital signs in general medicine inpatients.

RESULTS
Survey requests were sent to individuals representing 140 unique hospitals. Responses were received from 74 hospitalists, representing a 53% response rate. Routine vitals were most commonly characterized as those collected every 4 hours (78%; 95% confidence interval, 67%–87%), though at least 1 in 5 hospitalists reported obtaining all or select vital signs (eg, blood pressure) less frequently. Strategies to decrease vital sign frequency varied.

CONCLUSIONS
Our results suggest routine vital signs are not a normative concept across all patient populations in pediatrics. We further identify several conditions under which deviation from routines are sanctioned.
Resistance of breast cancer cells to all-trans retinoic acid is associated with a decrease in the basal level of nuclear receptor <i>RARα</i> expression and induction of cytochrome <i>CYP26A1</i> and <i>CYP26B1</i> expression
Authors: Enikeev A. D. , Komelkov A. V. , Elkina N. V. , Akselrod M. E. , Kuzmichev S. A. , Tchevkina E. M. 
Published: June 2022

Introduction. Retinoic acid (RA) is a key regulator of cell differentiation and a critical player in such systemic processes in the body as embryonic development, immune system cell maturation and functioning, tissue remodeling and several others. This compound displays an antitumor activity due to its ability to stimulate differentiation, induce apoptosis and inhibit proliferation of malignant cells. The rapid acquisition of resistance to RA and its analogues by solid tumor cells is one of the main problems limiting the widespread use of retinoids in the therapy of malignant neoplasms. The mechanisms of RA-resistance are still poorly understood.The study objective – assessment of the relationship between the basal expression level of the nuclear RARα receptor and the RA-induced expression of the cytochromes CYP26A1and CYP26B1 with the resistance of breast cancer cells to the action of all-trans-retinoic acid.Materials and methods. Cell lines were cultured, the sensitivity of breast cancer cells to the action of fully trans-retinoic acid, RNA isolation, reverse transcription reaction and real-time polymerase chain reaction were analyzed).Results. In present study, using an experimental model represented by 9 breast cancer cell lines with different level of sensitivity to RA, we showed that the expression of the RA nuclear receptor RARα, as well as the level of mRNA induction of CYP26A1 and CYP26B1 cytochromes in response to RA treatment correlate with RA-sensitivity.Conclusion. Thus, a decrease of RARα expression as well as the reduced ability to catabolize RA are factors associated with RA-resistance of breast cancer cells.
Metabolism of tryptophan in non-small lung cancer patients with different effect of PD-1 / PD-L1 inhibitors immunotherapy
Authors: Zlatnik E. Yu. , Sagakyants A. B. , Novikova I. A. , Maksimov A. Yu. , Shatova O. P. , Appolonova S. A. , Moskaleva N. E. , Rumyantsev S. A. , Shestopalov A. V. 
Published: June 2022

Introduction. In the structure of cancer incidence, lung cancer ranks first among men. In order to study the molecular mechanisms of the initiation and progression of lung cancer, it is necessary to study not only the tumor cells themselves, but also the features of the systemic tryptophan metabolism. Tryptophan catabolites, being to a large extent product of the metabolic activity of the intestinal microbiota, can affect the effectiveness of immunotherapy with checkpoint inhibitors. The kynurenine pathway of tryptophan metabolism is intensified in the body of cancer patients; its products have a pro-oncogenic and immunosuppressive effect, which may hinder the effectiveness of immunotherapy.Objective – to study the dynamics of changes in various metabolites of tryptophan metabolism in the blood serum and feces of patients with non-small cell lung cancer with various effects of immunotherapy with inhibitors of PD-1 (programmed cell death receptor 1) / PD-L1 (programmed cell death receptor 1 ligand).Materials and methods. The study included blood serum and stool samples obtained from 20 patients with non-small cell lung cancer treated with PD-1 / PD-L1 inhibitors. Using high-performance liquid chromatography with mass spectrometric analysis, the levels of 13 tryptophan metabolites were assessed in patients with various effects of immunotherapy. The significance of differences between the samples was assessed using a nonparametric method according to the Mann – Whitney test. They were considered statistically significant at p <0.05.Results. In fecal analyzes of patients in whom a positive effect of immunotherapy was observed, baseline levels of 5-hydroxyindole acetate and quinolinic acid were lower than in patients with tumor progression. Positive clinical dynamics was accompanied by a decrease in the content of indole-3-lactate, kynurenine and indole-3-carboxaldehyde in the feces of patients. In the serum of patients with a positive response, the initial content of 5-hydroxyindole acetate, indole-3-acetate, indole-3-butyrate and quinoline acid was lower than in patients with progression of non-small cell lung cancer. A positive response to immunotherapy was characterized by an increase in the levels of indole-3-butyrate and indole-3-propionate, and a negative response was not accompanied by statistically significant changes in the studied tryptophan metabolites.Conclusion. Profiling tryptophan metabolites in feces and serum of patients with non-small cell lung cancer can be used to predict the effectiveness of immunotherapy with PD-1 / PD-L1 inhibitors.
Novel Method of Improving Quality of Service for Voice over Internet Protocol Traffic in Mobile Ad Hoc Networks
Authors: Shakir Abdullah , Alsaqour Raed , Abdelhaq Maha , Alhussan Amal , Othman Mohd , Mahdi Ahmed 
Published: June 2022

In recent years, the application of Mobile Ad-hoc Network (MANET) with Voice over Internet Protocol (VoIP) has been increased. However, the level of Quality of Service (QoS) for VoIP traffic in MANET, while there is no infrastructure, will reduce when dealing with a large number of calls. In this type of dynamic environment, the developing of a new infrastructure becomes more costly and time-consuming. In this paper, we proposed an efficient method, called the Quality of Service-Nearest Neighbor (QoS-NN), to improve the QoS level for VoIP in order to manage the huge number of calls over MANET network. We utilized the Ad-hoc On-demand Distance Vector (AODV) protocol as the underlying routing protocol to implement our proposed method. We evaluated the proposed QoS-NN method using Network Simulator version 2 (NS2). The performance of the proposed QoS-NN method was compared with Lexicographic order method. The comparison was evaluated in terms of R-factor, end-to-end delay, packet loss ratio, and packet delivery ratio performance metrics. In addition, the proposed method evaluated under different network parameters such as VoIP CODECs, node mobility speed, number of calls and number of nodes. The comparison results indicate that the proposed QoS-NN outperform the Lexicographic order method.
The impact of the COVID-19 pandemic on the activities of health care personnel
Authors: Popsuyko A. N. , Danilchenko Ya. V. , Batsina E. A. , Trauter M. K. , Makarov S. A. , Artamonova G. V. 
Published: June 2022

Highlights. In order to provide medical care to COVID-19 patients, medical workers had to work in conditions of extreme stress. The management systems adapted to such challenges contribute to the creation of more stable and organized structures that require substantial study concerning the medical personnel effectiveness and satisfaction of the job, taking into account the sphere of medical care.Aim. To examine the impact of the pandemic on the staff activities in the sphere of cardiology.Methods. The object of the study is medical organization personnel. The subject of the study is the GBUZ “KKKD” personnel opinion. The study periods are 2012 and 2021. Rating questions were coded with a five-point Likert scale. The mean value and standard deviation (M±SD), Pearson Chi-square, p (%) were calculated. The critical level of statistical significance was taken as p≤0.05.Results. The study showed a significant increase in high estimates of the staff performance both at the unit and organization where the respondent worked. The high subjective ratings are confirmed by the objective data of GBUZ “KKKD” activity in 2021. However, the pandemic situation reflected on the personnel perception of their productivity: there is an increase of high productivity positive assessment both in a structural division and in the whole organization. 2021 survey revealed the conditions caused by the COVID-19 pandemic which affected the performance of the staff. Among the most significant ones are the following: the lack of necessary reagents, worsening of financial and living conditions, epidemiological restrictions, the lack of actions and orders coordination, heavy workload, fatigue and burnout, the reduction of salary, irresponsibility of patients and their removal to different departments, bureaucracy, the lack of information and staff interaction. The study also showed an increase in the proportion of respondents' answers regarding the inability to work more efficiently from 21.6% in 2012 to 29.4% in 2021, which may be caused by the work stress and the special working conditions during the COVID-19 pandemic. All the reasons why it was impossible to work efficiently during the pandemic were divided into three groups: managerial, personal and clinical-organizational.Conclusion. The impact of the COVID-19 pandemic on staff performance is evident judging by the evaluation dynamics in two sociological studies. The prior factors of performance improvement and staff satisfaction include: expansion of social benefits, favorable moral-psychological climate and working conditions. The study shows that in order to achieve the main goals of medical organization in the conditions of insurmountable risk the personnel have a significant role in making organizational decisions.
Optimization of the biological valve appliance prosthetic heart valve
Authors: Ovcharenko E. A. , Onishchenko P. S. , Klyshnikov K. Yu. 
Published: June 2022

Highlights. With the use of numerical optimization algorithms, it is possible to qualitatively improve the performance (closing) of the leaflet apparatus of the heart valve prosthesis. Changing the length of the free edge of the lealflet of the prosthesis does not reduce the von Misess stress amplitude and does not change the nature of its distribution on the diagrams.Aim. Numerical study of the stress-strain state of a clinical heart valve prosthesis from the point of view of the impact of physiological loads and determination of ways to optimize the geometry of the biological leaflet apparatus.Methods. The object of study was a three-dimensional model of the UniLine (NeoCor, Russia) clinical prosthesis of the heart valve, size 23 mm, as well as four modifications focused on changing the length of the free edge. The study was carried out using the finite element method with imitation of the full cycle of operation of the leaflet apparatus under physiological conditions (pressure, heart rate). The parameters for the analysis were the qualitative and quantitative characteristics of the stress-strain state of the work of the five studied geometries.Results. It is shown that high stress areas are concentrated in two zones peripheral and free edges, regardless of the geometry. However, quantitatively, the von Mises stress amplitudes differed between the studied models. For example, the leaf shape, conventionally designated as “–10” degrees, demonstrated the smallest amplitude of this indicator relative to the original unmodified leaf model, thus reducing by a maximum of 18.8%. However, for the closed state, this model, on the contrary, showed an increase in the voltage index relative to the initial one by 8.3%. Other modification options showed similar trends.Conclusion. It is shown that despite the initial premise for optimizing the leaflet apparatus – reducing the length of the free edge and eliminating deformations of the closed state, the proposed geometry options did not significantly change the stress distribution map in the material, and also did not allow to significantly reduce the amplitudes of this parameter. Presumably, options for modifying the geometry and/or properties (rigidity, mobility) of another important component of the bioprosthesis, the support frame, which, in addition to the bearing function, provides damping of the hydrodynamic impact on the leaf due to some of its mobility, may become more promising.
Maternal and perinatal outcome in placenta previa: a prospective observational study at a tertiary care hospital in Hanmakonda, Telangana, India
Authors: Manognya Alicatta 
Published: June 2022

Background: Placenta previa is a major cause of maternal morbidity and mortality. A multi-disciplinary team approach is necessary to manage this condition. The wide spread use of ultrasonography in obstetrics in current days aided in early diagnosis of placenta previa. The present study was done to evaluate the maternal and fetal outcome in placenta previa in tertiary care centre.Methods: This prospective study was conducted at Department of Obstetrics and Gynecology of Kakatiya Medical College under Government Maternity Hospital, Hanmakonda, Telangana during the period of June 2019 to September 2020.Results: In present study, total number of placenta previa cases were 42 out of 7564 with an incidence of 0.55%. Majority were in the age group 20-29 years (88%). The major risk factor was previous caesarean delivery seen in 64.2% cases. The 19% cases presented with breech presentation. Majority were type 2 placenta previa (52.3%). Incidence was more among un booked cases (66.6%). The incidence of post-partum hemorrhage was 16.6%. Hysterectomy was done in 7.14%. Perinatal mortality due to asphyxia was 2.38%, prematurity was 4.76%. Perinatal mortality rate was 1.05%.Conclusions: Placenta previa has significant maternal and fetal risk. Accurate diagnosis, and timely intervention can lead to favourable outcome. Educating patients regarding the complications like post-partum hemorrhage, need for blood transfusions, and taking the neonatologist opinion will reduce the maternal and perinatal complications. Early referral, and proper health education will help in better outcome of both mother and fetus.
Changing trends in fetomaternal outcome in COVID-19 in pregnancy
Authors: Parikh Purvi M. , Vyas Rupa C. , Bhatiya Rekha K. , Shah Sapana R. , Chudasama Tanmay J. 
Published: June 2022

Background: This study is to provide an overview of the clinical course and outcome of COVID in pregnancy in both first wave and second wave, to study about different parameters affected significantly in both waves.Methods: This is a retrospective comparative study that was conducted by dividing the patients into group 1 and group 2. Group 1 was treated in 2020 (wave 1) whereas group 2 in 2021 (wave 2). A laboratory confirmed positive cases of COVID-19 infection in pregnant women were included. All the patients were further categorized into mild, moderate and severe subgroups according to the ICMR criteria. Results: The study of the first (2020) and second (2021) wave of COVID-19. In group 1 and group 2, there were a total of 359 cases and 145 cases respectively. In group 1, there were 54/359 (15.04%) moderate cases and in group 2 there were 17/145 (11.72%) moderate cases. While there were 101/359 (28.13%) and 106/145 (73.10%) severe cases in group 1 and group 2 respectively. Most of severe cases of second group associated with breathlessness, tachypnoea and fall in oxygen saturation level ended with mechanical ventilation by O2 mask (7.54%), NRBM (8.49%), HFNC (14.15%), BIPAP (12.26%), invasive ventilation (22.64%). Conclusions: The results of study show that hospitalized patients in the second wave were younger, required hospitalization, and had higher mortality rates.