bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Klotho Concentrations in Young and Older Men During Prolonged
Exercise in Temperate and Hot Conditions
Authors: King Kelli E. , McCormick James J. , Notley Sean R. , Fujii Naoto , Kenny Glen P. 
Published: March 2022

Background:
The protein klotho protects cellular function during various physiological
stressors, such as exercise, however it is unknown how the age-related decline in klotho production
affects responses during exercise, especially in the heat.

Objective:
Our objective was to determine the effect of exercise in temperate and hot environmental
conditions on serum klotho concentrations in young and older men.

Methods:
12 young (mean ± SD: 22 ± 3 years) and 12 older (59 ± 4 years) men performed 180
minutes of moderate-intensity treadmill walking (metabolic rate: 200 W/m2) in a temperate (wetbulb
globe temperature [WBGT] 16°C, achieved with 21.9°C, 35% relative humidity [RH]) and hot
(WBGT 32°C, achieved with 41.4°C, 35% RH) environment. Serum klotho was assessed before
and after exercise, as well as 60-min post-exercise recovery in the respective environments.

Results:
Absolute klotho concentrations were greater in young versus older men during all measured
time points in the temperate (p = 0.032), but not the hot condition (p = 0.064). In the hot condition,
the change in serum klotho from baseline was significantly higher after exercise in the heat
(mean ± SEM: +251 ± 73 pg/mL) than the temperate (+75 ± 57 pg/mL) environment in both groups
(p = 0.026). However, this elevation was not maintained during recovery.

Conclusion:
We showed that prolonged exercise in a temperate environment does not elicit a
klotho response in either group. In contrast, despite lower resting klotho levels, the older men
showed a similar exercise-induced increase in serum klotho response as their younger counterparts.
A Review on Potential Activities of Different Parts of Cassia sophera as Antidiabetic,
Antimicrobial and Anticancer Agent
Authors: Chakraborty Atyurmila , Acharjya Sasmita Kumari , Tripathy Bimala , Shree Dipthi 
Published: March 2022

Background:
Herbal medicines are one of the giant creations of nature. Several medicinal agents developed from natural sources, which open a new era of health sciences. Cassia sophera is a prevalent medicinal plant that is locally known as “Kasondi”, belonging to the family Caesalpinaceae. Many secondary metabolites like alkaloids, tannins, anthraquinones, flavonoids are isolated from roots, stems, leaves, flowers, and seeds of C. sophera, which are very effective against several diseases.

Objective:
Cassia sophera has an enormous potential in public health to protect from diabetes, microbes, and cancer. Hence, the aim of the present review is to collect the reported antidiabetic, antimicrobial, and anticancer activity of Cassia sophera along with a detailed discussion about mechanism of action of var-ious phytoconstituents.

Discussion:
Antidiabetic activity of Cassia sophera is due to the activation of β cell and stimulation of surviving pancreatic β-cells to release more insulin. Plasma membrane disruption, inhibition of cell wall formation, inhibition of cell division by the Cassia sophera is the prime causes of antimicrobial activity. The anticancer activity of the plant is mainly due to the prevention of reactive oxygen species formation, induction of cell cycle arrest, apoptosis, and angiogenesis.

Conclusions:
The findings from this review article confirm the potential activities and mechanisms of various phytoconstituents responsible for preventing diabetes, cancer, and microbial infections. Further investigation regarding possible pharmaceutical side effects, contraindications, drug interactions involv-ing drugs synthesized from C. sophera should be carried out by the researchers.
A Review on Unknown Repercussions Associated with Metallic Nanoparticles and their Rectification Techniques
Authors: Aqeel Saman , Gupta Aparna , Singh Lalit 
Published: March 2022

Background:The wide use of metallic nanoparticles (MNPs) has toxic effects on the human body affecting vital organs such as brain, liver and kidney. Therefore it is necessary to develop approaches to eradicate such health issues without compromising plus the potential benefits of the respective metallic nanoparticles including silver, gold, zinc, copper, etc.Objective:This study aimed to assess methods which can mutually reduce the nanotoxicity while retaining the therapeutic benefits of metal-based nanocarriers.Methods:The implementation of certain methods, such as the addition of chelating agents, providing protective coatings and surface modification during the synthesis of metallic nanoparticles can subsequently minimize metallic toxicity.Results:Through extensive and exhaustive literature survey it was proved that the above strategies are effective in reducing nanotoxic effects which can be further assessed by toxicity assessment tools as biochemistry, histopathology, etc.Conclusion:Metallic nanoparticles have emerged as a beneficial tool for treating various diseases such as cancer, hepatitis, etc. Scientists are also preserving their efficacy by escorting novel techniques for limiting its toxicity in the world of nanotechnology.
Role of Cytokines in Chemotherapy-related Cognitive Impairment of
Breast Cancer Patients: A Systematic Review
Authors: Khan Mohd. Ashif , Tyagi Kanika , Masoom Md. , Majid Haya , Garg Aakriti , Bhurani Dinesh , Agarwal Nidhi B. 
Published: March 2022

Background:
Cognitive impairment is one of the most common problems experienced by
patients receiving chemotherapy, and evidence suggests that cytokines might play an important role.
Various studies were conducted to evaluate the role of cytokines in chemotherapy-related cognitive
impairment (CRCI). However, the association between CRCI due to cytokines is not well-established.
Thus, this systematic review aims to assess the role of cytokines in CRCI in breast cancer patients.

Methods:
This systematic review was conducted according to the Preferred Reporting Item for Systematic
Review and Meta-analysis (PRISMA) guidelines. An intense literature search was carried out
for inclusion criteria in major databases, including PubMed and Clinicaltrials.gov, in August 2021.
Studies assessing cognitive parameters through objective and subjective assessment in breast cancer
patients receiving chemotherapy were included.

Results:
A total of 4052 studies were identified, and 15 studies were included in this systematic review.
We found that IL-6, IL-1β, and TNF-α were associated with varying degrees of cognitive impairment
in breast cancer patients receiving chemotherapy.

Conclusion:
This systematic review showed a correlation between various cytokines and chemotherapy-
associated cognitive decline in breast cancer patients.
Penguatan “Kaulinan Barudak Sunda” sebagai permainan tradisional
Authors: Dermawan Windy , Purnama Chandra , Mahyudin Emil 
Published: March 2022

This article aimed to strengthen “Kaulinan Barudak Sunda” as a traditional game towards the community in an effort to improved cultural security in Jatinangor District. To achieved this goal, we provided an understanding of the importance of “Kaulinan Barudak” traditional games towards the community through Focus Group Discussion regarding the identification and formulation of activity objectives, socialization, mentoring and practised of Kaulinan Barudak Sunda for children, and evaluation of activities. The method of implementing this activity was Problem Based Learning by solving problems that occurred regarding the fading of knowledge and practised of Kaulinan Barudak Sunda among children, also carried out with the Community Based Research method by involving the community in compiling shared ideas as needed. Based on the resulted of data analysis, we concluded that there was an increase of 68.5% in the aspects of the participants' perceptions, attitudes, and actions regarding traditional games. Thus, this activity contributed to providing knowledge, attitudes, and actions of participants in supporting the strengthening of Kaulinan Barudak Sunda in the Jatinangor District. AbstrakArtikel ini bertujuan memberikan penguatan Kaulinan Barudak Sunda sebagai permainan tradisional terhadap masyarakat sehingga dapat meningkatkan keamanan kultural di Kecamatan Jatinangor. Untuk mencapai tujuan tersebut, kami memberikan pemahaman mengenai pentingnya permainan tradisional Kaulinan Barudak Sunda terhadap masyarakat melalui kegiatan diskusi kelompok terfokus (Focuss Group Discussion) mengenai identifikasi dan perumusan tujuan kegiatan, sosialisasi kegiatan, pendampingan dan praktek beberapa bentuk Kaulinan Barudak Sunda kepada anak-anak, dan evaluasi kegiatan. Metode pelaksanaan kegiatan ini adalah Problem Based Learning dengan memecahkan permasalahan yang terjadi mengenai lunturnya pengetahuan dan praktek Kaulinan Barudak Sunda di kalangan anak-anak, juga dilakukan dengan metode Community Based Research dengan melibatkan masyarakat dalam menyusun gagasan bersama yang diperlukan. Berdasarkan hasil analisis data, kami menyimpulkan bahwa terdapat peningkatan sebesar 68,5% pada aspek persepsi, sikap dan tindakan peserta mengenai permainan tradisional. Dengan demikian, kegiatan ini berkontribusi memberikan pengetahuan, sikap dan tindakan peserta di dalam mendukung penguatan Kaulinan Barudak Sunda sebagai permainan tradisional di Kecamatan Jatinangor.
Drawing method with crayons as a medium of expression and imagination for children
Authors: Ariani Ariani , Werdina Woro Asty , Nugrahadi Gihon , Soeriaatmadja Rully 
Published: March 2022

Drawing is a medium of expression and a part of children’s creative and imaginative process. Children can create, share ideas, visualize and realize their imagination through drawing. Drawing with crayons is familiar to children but this does not apply to the children of age between 5 – 12 years old who live in Karawaci district, Indonesia. These children did not have the opportunity to learn additional skills through informal education due to their families’ financial constraint. The purpose of this activity is to provide training in the right drawing methods and to train children to be creative in dealing with the limitations of the financial conditions. A qualitative method with a case study approach is used to achieve the objectives and determine the answers to the problems encountered in this research. Out of the five methods introduced, the blocking and mixing methods were the most preferred techniques by the children because it was easy to use and produced drawing with bright colours which represent their expression and imagination.
Pelatihan pembuatan minuman berserat alami dari buah nanas dan nata de coco
Authors: Ramadani Aisyah Hadi , Rosalina Reny , Ningrum Riska Surya 
Published: March 2022

Salah satu sentra produksi nanas di Jawa Timur adalah di Dusun Puhrejo, Kecamatan Ngancar, Kabupaten Kediri. Nanas yang dihasilkan dijual dalam bentuk buah segar dan olahan, contohnya adalah sari nanas. Kualitas produk olahan sari nanas masih kurang maksimal sehingga pada kegiatan ini diberikan pengetahuan dan pelatihan tentang cara pengolahan buah nanas dalam bentuk minuman berserat. Minuman berserat dibuat dari campuran buah nanas yang kaya nutrisi dan nata de coco yang mengandung serat alami. Penambahan nata de coco juga berfungsi sebagai penstabil (emulsifier) agar produk minuman yang dihasilkan memiliki mutu yang lebih baik dan daya simpan yang lebih lama. Terdapat 2 tahapan kegiatan yang diikuti oleh 25 warga Dusun Puhrejo, yaitu penyuluhan dan pelatihan. Hasil yang diperoleh dari kegiatan ini adalah adanya peningkatan pengetahuan peserta mengenai pemanfaatan dan cara pengolahan nanas yang tepat sehingga tidak mengurangi kandungan gizi di dalamnya. Minat peserta untuk mengembangkan produk olahan nanas juga meningkat karena produk yang dihasilkan dapat memberi nilai tambah buah nanas. Produk olahan yang diperoleh dari kegiatan ini juga dijadikan produk unggulan UMKM Dusun Puhrejo. Training on produce a healthy beverage from pineapple fruits and nata de coco AbstractOne of the pineapple production centers in East Java is in Puhrejo village, Ngancar, Kediri. The pineapple was sold in the fresh and processing fruits, like pineapple juice. But the pineapple juice has low quality so this activity gave information and training about how to process pineapple to be a healthy beverage product. A healthy beverage produced from pineapple that contains many nutritions and nata de coco that contain natural fibre. The aim of addition nata de coco is as emulsifier therefore the beverage obtained from this project has better quality and longer shelf life. The activity was attended by 25 Puhrejo village residents and used two steps, that are counselling and training. The result of the activity is an increase in the community’s knowledge about the potential of pineapple and the right processing of it so the nutrition did not decrease. The desire of the community to process pineapple into a variety of products also increased because that product can provide added value to pineapple. The healthy beverage product from this activity will be a superior product from UMKM of Puhrejo village
Pemanfaatan Media untuk Meningkatkan Kesadaran Perempuan terhadap Kesehatan Reproduksi
Authors: Widyastuti Dhyah Ayu Retno , Vidiadari Irene Santika 
Published: March 2022

Abstrak: Media merupakan salah satu komponen komunikasi yang mempengaruhi kehidupan manusia sehari-hari. Pada masyarakat yang cenderung aktif, mereka bisa menyeleksi informasi yang ingin dikonsumsi. Namun realitanya, terdapat kondisi perempuan yang harus bekerja di wilayah domestik dengan keterbatasan kemampuan dalam mengakses informasi. Berdasar realita ini, dibutuhkan sebuah program pendampingan literasi media untuk perempuan. Program pendampingan yang dirancang mengombinasikan isu kesehatan reproduksi dan isu pemanfaatan media. Program kegiatan yang dilaksanakan oleh tim meliputi (1) Pengenalan media komunikasi; (2) Pemanfaatan media sebagai sumber informasi dan literasi media; (3) Keterkaitan media dengan kesehatan reproduksi dan pendampingan kesehatan reproduksi remaja. Simpulan dari kegiatan pendampingan ini adalah (a) Melalui kegiatan pengabdian ini, tim melihat bahwa terdapat peningkatan pemahaman dan pengetahuan keberadaan jenis-jenis media sosial dan fungsinya; (b) Kelompok sasaran mengakses informasi media sosial yang relevan dengan kebutuhan mereka sehari-hari dalam rangka mendampingi anak; (c) Kelompok sasaran dapat memanfaatkan akses informasi mengenai kesehatan reproduksi; (d) Kemampuan menyaring berita yang tidak benar (hoaks) yang tersebar melalui media sosial yang mereka miliki. Using Media to Increase Awareness of Women’s Reproductive Health Abstract: Communication media is one component of communication that affects human life. For active communities, they can select the information they want to consume. However, there are conditions for women who have to work in domestic areas with limited ability to access information. From this reality, it takes a media literacy program for women. The mentoring program designed combines reproductive health issues and issues of media use. The program activities carried out by the team include (1) Introduction of communication media; (2) Use of the media as a source of information and media literacy; (3) The concept of reproductive health and assisting reproductive health for teenagers. The conclusions from this mentoring activities are (a) Through this service activities, the team see there is an increase in understanding of social media’s variations and their functions;(b) Target groups access social media that is relevant to their daily needs in order to assist their children; (c) Target groups can use access to information on reproductive health; (d) The ability to filter hoax news spread through social media they have.
Artificial Intelligence Education for the Health Workforce: Expert Survey of Approaches and Needs
Authors: Gray Kathleen , Slavotinek John , Dimaguila Gerardo Luis , Choo Dawn 
Published: March 2022

BackgroundThe preparation of the current and future health workforce for the possibility of using artificial intelligence (AI) in health care is a growing concern as AI applications emerge in various care settings and specializations. At present, there is no obvious consensus among educators about what needs to be learned or how this learning may be supported or assessed.ObjectiveOur study aims to explore health care education experts’ ideas and plans for preparing the health workforce to work with AI and identify critical gaps in curriculum and educational resources across a national health care system.MethodsA survey canvassed expert views on AI education for the health workforce in terms of educational strategies, subject matter priorities, meaningful learning activities, desired attitudes, and skills. A total of 39 senior people from different health workforce subgroups across Australia provided ratings and free-text responses in late 2020.ResultsThe responses highlighted the importance of education on ethical implications, suitability of large data sets for use in AI clinical applications, principles of machine learning, and specific diagnosis and treatment applications of AI as well as alterations to cognitive load during clinical work and the interaction between humans and machines in clinical settings. Respondents also outlined barriers to implementation, such as lack of governance structures and processes, resource constraints, and cultural adjustment.ConclusionsFurther work around the world of the kind reported in this survey can assist educators and education authorities who are responsible for preparing the health workforce to minimize the risks and realize the benefits of implementing AI in health care.
La relevancia de los lenguajes estéticos en los procesos educativos
Authors: Fernández De Córdova Camila , Mediavilla Naranjo Enrique 
Published: March 2022

La puesta en valor del universo de los lenguajes estéticos con relación a las necesidades de la sociedad contemporánea y el permanente cuestionamiento de la vigencia de las estructuras educativas tradicionales desemboca en la búsqueda de nuevas alternativas pedagógicas. En este sentido, se reflexiona sobre la necesidad de entretejer los ámbitos artísticos, simbólicos y estéticos con las diversas áreas de aprendizaje, a la luz de perspectivas que tengan la intención de resignificar las dimensiones que configuran los procesos educativos. Además, se vislumbra la importancia de generar oportunidades formativas que atiendan a la figura docente con la intención de que se establezca como el vector fundamental de transformación y mejora de la calidad educativa, a partir de las experiencias cognitivas y emocionales que se generan desde la expresión estética.
Aprendizajes de los profesores sobre la docencia en una sociedad conectada
Authors: Romanowski Joana Paulin , Manosso Cartaxo Simone Regina , Hoça Liliamar , Martins Pura , Mendes Ademir 
Published: March 2022

El artículo tiene como problema: ¿cómo aprenden los docentes en una sociedad conectada? El objetivo es conocer cómo son desarrollados los procesos de aprendizaje de los docentes, en una sociedad conectada que les ofrece alternativas, formales e informales, para mejorar su conocimiento profesional. La investigación tiene un enfoque cualitativo y los datos fueron obtenidos a través de un cuestionario respondido por 245 docentes de todas las regiones de Brasil. Los hallazgos indican que los docentes aprenden, en la práctica, mediante investigación, de manera interactiva en grupos colaborativos y a través de procesos de autoformación. Se evidencia que la formación docente se produce a través del aprendizaje formal e informal, y que estos aprendizajes se asocian a su formación y desarrollo profesional, y elevan el estatus de profesionalización de los docentes.
Del maestro al educador profesional. Bases para la profesionalización
Authors: Aguerrondo Inés 
Published: March 2022

El propósito de este artículo es indagar las dificultades que conlleva el intento de profesionalizar la docencia, ya que el aprendizaje profesional ha sido reconocido como la característica clave de la educación de los profesores. Una razón podría ser que no se ha problematizado la identidad docente ni se ha revisado cómo ciertas clasificaciones o perfiles docentes delimitan las condiciones de posibilidad de la docencia como profesión. Otra razón que conspira contra la profesionalización docente es que pasar la formación docente a la educación superior no significó superar un rasgo que caracteriza a la pedagogía, cuyo origen no está en la reflexión filosófica sino en la moral y el método. Este artículo completa su propósito explicitando las bases de la experiencia de formación docente de la Pontificia Universidad Católica Argentina, el Modelo de Aprendizaje Inclusivo y Efectivo (AIE), que redefine la identidad profesional dentro de una concepción actualizada del conocimiento, como multidimensional, complejo y situado.
Genetic Causes, Clinical Manifestations and Diagnosis of Central Nervous System Malformations with Emphasis on Corpus Callosum
Authors: Alomrani Basmah , Javed Murid , Mohammed Ali Hani S. H. , Abo-Aba Salah E. M. , AlBakheet Albandary , Alqudairy Hanan , Kaya Namik 
Published: March 2022

The pathological processes of the central nervous system, intrinsic or extrinsic, occurring during the embryonic period are the most common cause of pregnancy termination. The defects of the neural tube which is primitive form of brain and spinal cord are the most common central nervous system (CNS) malformations. In some defects the fetus continues to develop and results in the birth of a child with sever mental and physical deficiencies. The corpus callosum is the largest white matter tract connecting the two cerebral hemispheres and permits the transfer of information between the two cerebral hemispheres. Its partial or complete agenesis is caused by abnormalities during embryonic development. The severity of symptoms varies widely depending on the degree of dysgenesis. Hypotonia, visual impairment, seizures, spasticity, motor co-ordination issues, and atypical facial features are common symptoms. In this review we focus on genetic causes, clinical manifestations and diagnosis of various malformations of central nervous system with special emphasis on Corpus Callosum.
Combining Image Processing Techniques and Mobile Sensor Information for Marker-less Augmented Reality Based Reconstruction
Authors: Weerakkody I. S. , Sandaruwan K. D. , Kodikara N. D. 
Published: March 2022

Marker-less Augmented Reality(AR) based recon- struction using mobile devices, is a near impossible task. When considering vision based tracking approaches, it is due to the lack of processing power in mobile devices and when considering mobile sensor based tracking approaches, it is due to the lack of accuracy in mobile Global Positioning System(GPS).
In order to address this problem this research presents a novel approach which combines image processing techniques and mobile sensor information which can be used to perform precise position localization in order to perform augmented reality based reconstruction using mobile devices. The core of this proposed methodology is tightly bound with the image processing technique which is used to identify the object scale in a given image, which is taken from the user’s mobile device. Use of mobile sensor information was to classify the most optimal locations for a given particular user location.
This proposed methodology has been evaluated against the results obtained using 10cm accurate Real-Time Kinematic(RTK) device and against the results obtained using only the Assisted Global Positioning System(A-GPS) chips in mobile devices. Though this proposed methodology require more processing time than A-GPS chips, the accuracy level of this proposed methodology outperforms that of A-GPS chips and the results of the experiments carried out further convince that this proposed methodology facilitates improving the accuracy of position local- ization for augmented reality based reconstruction using mobile devices under certain limitations.