bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis
Authors: Medvedev Kirill E , Savelyeva Anna V , Chen Kenneth S , Bagrodia Aditya , Jia Liwei , Grishin Nick V 
Published: October 2022

Objective: Testicular germ cell tumors (TGCT) are the most common solid malignancy in adolescent and young men, with a rising incidence over the past 20 years. Overall, TGCTs are second in terms of the average life years lost per person dying of cancer, and clinical therapeutics without adverse long-term side effects are lacking. Platinum-based regimens for TGCTs have heterogeneous outcomes even within the same histotype that frequently leads to under- and over-treatment. Understanding of molecular differences that lead to diverse outcomes of TGCT patients may improve current treatment approaches. Seminoma is the most common subtype of TGCTs, which can either be pure or present in combination with other histotypes. Methods: Here we conducted a computational study of 64 pure seminoma samples from The Cancer Genome Atlas, applied consensus clustering approach to their transcriptomic data and revealed 2 clinically relevant seminoma subtypes: seminoma subtype 1 and 2. Results: Our analysis identified significant differences in pluripotency stage, activity of double stranded DNA breaks repair mechanisms, rates of loss of heterozygosity, and expression of lncRNA responsible for cisplatin resistance between the subtypes. Seminoma subtype 1 is characterized by higher pluripotency state, while subtype 2 showed attributes of reprograming into non-seminomatous TGCT. The seminoma subtypes we identified may provide a molecular underpinning for variable responses to chemotherapy and radiation. Conclusion: Translating our findings into clinical care may help improve risk stratification of seminoma, decrease overtreatment rates, and increase long-term quality of life for TGCT survivors.
Electromagnetic shielding behaviors of planar frequency selective surface fabrics, with emphasis on decoupling analysis, lamination direction and tunable selective frequency
Authors: Zheng Yiqian , Wang Yunyang , Zhu Chengyan , Wang Qicai , Qiu Haibin , Qian Junnan , Hong Xinghua 
Published: October 2022

Planar frequency selective surface (FSS) fabrics with grids, strips or patches by simple methods of patching, embroidery, clipping and carving were fabricated. The periodic structures, laminated structures, processing method and materials pertaining to the electromagnetic shielding behaviors were investigated. Firstly, equivalent circuit and electromagnetic (EM) shielding behavior of basic frequency selective structure units and complex fretwork structure were provided, involving the decoupling of complex fretwork structure. In addition, various laminating structures of SPs and SGs were determined, one of superposition of SPs and SGs provides a SE peak of 40.2 dB (average SE of 25.1 dB in the whole frequency domain), the other presents a SE peak of 27.1 dB (average SE of 19.1 dB in the whole frequency regime). Furthermore, tunable selective electromagnetic shielding by a simple mechanical way was provided, which can realize a tunable SE peak varying from 730 MHz to 1580 MHz. This work might provide a perspective for the assemble and analytical approximation of FSS fabrics for scientists and engineers in this cross-disciplinary field.
The Use of Traditional Chinese Medicine in Patients with Oral, Oropharynx, Nasopharynx, and Hypopharynx Cancers: A Retrospective Longitudinal Cohort Study in Taiwan
Authors: Ben-Arie Eyal , Inprasit Chanya , Lottering Bernice , Yip Hei-Tung , Ho Wen-Chao , Lee Yu-Chen , Kao Pei-Yu 
Published: October 2022

Introduction Given the prevalent use of tobacco and betel nut in the Taiwanese community, an increase risk of oral, oropharynx, and hypopharynx cancers (head and neck cancers) is apparent. The use of Traditional Chinese Medicine (TCM) and acupuncture is both common and conveniently accessible in Taiwan, with treatments being financially supported by the National Health Insurance (NHI). This study aims to investigate the use of TCM in head and neck cancers in Taiwan through a longitudinal cohort study. Methods: The Taiwan National Health Insurance Research Database (NHIRD) was utilized in order to conduct this study. The study populations consisted of oral, oropharynx, nasopharynx, and hypopharynx cancers (head and neck cancer) patients in 2002, which were then followed up until 2007 in regards to TCM use, until 2013 in regards to acupuncture use and until 2014 for all-cause mortality. Patients were divided into 4 groups. Common symptoms, Chinese herbs and formula used, TCM visits and 5 and 12 years all-cause mortality were analyzed. Results: The use of TCM was increased in the second to fourth-year post-diagnosis. TCM use in nasopharynx cancer patients was higher compared to other cancers. The number of TCM visits per patient was increased post-diagnosis. The findings suggest a non-significant reduction in 5 and 12 years all-cause mortality between TCM II and CON II groups. Conclusion: The use of TCM in new patients suffering from head and neck cancers was increased in close proximity to the cancer diagnosis. The relation between TCM use and mortality of head and neck cancer should be investigated through larger scale studies.
The Latino Paradox, the Racial Invariance Thesis, and Recidivism Among a Sample of Juvenile Offenders
Authors: Lowery Patrick G. , Zicari Dominic J. 
Published: October 2022

A plenitude of research on juvenile recidivism exists within the criminological literature, and some scholars have suggested using the Latino paradox and racial invariance thesis to make sense of racial and other disparities in recidivism. However, there is an extremely limited body of literature that tests one or both of these theories on juvenile recidivism, and the research which does exist is limited in its generalizability. To address this gap, we use statewide data from Virginia’s Department of Juvenile Justice over 5 years to test the Latino paradox and racial invariance thesis. Furthermore, given the nested nature of the data (juveniles within counties/independent cities), we merged county-level data from the Virginia State Police and American Community Survey into the data and used two-level hierarchical generalized linear models to analyze the data. Our findings largely supported the Latino paradox and offered some support for the second interpretation of the racial invariance thesis. Implications for theory and recommendations for public policy are discussed.
Routine Pathological Examination of Clinically Presumed Dupuytren Disease: Does It Add Value?
Authors: Uhlman Kathryn , Bonert Michael , Murphy Jessica , Duku Eric , Naqvi Asghar , Thoma Achilles 
Published: October 2022

Background: In surgery for Dupuytren disease (DD), palmar fascia specimens are routinely submitted for pathological evaluation. The purpose of this study was to determine the rate of discordant diagnosis and the value of, and costs associated with, routine pathological analysis of palmar fascia tissue extracted in surgery for clinically diagnosed DD. Methods: All pathology reports for in-house palmar fascia specimens obtained in surgery for clinically diagnosed DD (time period: January 2001 to December 2020) were retrieved from one academic institution. All specimens were classified by a hierarchical free-text string matching algorithm (HFTSMA) and searched for evidence of malignancy. The primary outcome was percentage of concordant, discrepant, and discordant diagnoses. Secondary outcomes included anatomical location and costs. The HFTSMA was used to capture the anatomical location. Costs included professional, laboratory processing, and ancillary fees based on the Ontario Schedule of Benefits. Results: The search retrieved 1323 pathology reports, with 1480 palmar fascia specimens, from 1078 individual patients. By diagnosis, 96.1% of specimens (1422/1480) were concordant (fibromatosis), 3.9% (58/1480) were discrepant (scarring/fibrosis, benign fascia/connective tissue, or other benign findings), and 0% (0/1480) were discordant. The most common location was ring finger (n = 381, 48.7%). Ancillary testing was minimal. The cost per palmar fascia specimen was estimated to be CAD $34.57. The institutional costs were approximately CAD $2558.18/year. Conclusions: Routine pathological examination of specimens in cases of clinically diagnosed DD does not yield additional clinically important findings and may not warrant their costs.
High expression of ECT2 and E2F1 is associated with worse clinical manifestations and prognosis in patients with oral squamous cell carcinoma
Authors: Peng Shixiong , Wang Jinhang , Chen Yanping , Hei Naiheng , Zhao Jianguang , Wu Xinjuan , Cui Zifeng 
Published: October 2022

To detect the expression, prognostic value, and possible effects of epithelial cell transforming sequence 2 (ECT2) and E2F1 in patients with oral squamous cell carcinoma (OSCC). Seventy subjects hospitalized for OSCC surgical treatment in the Fourth Hospital of Hebei Medical University were selected for this study. Expression levels of ECT2 and E2F1 were detected by qRT-PCR, Western blot, and immunohistochemistry. The Kaplan-Meier method and Cox risk proportional regression analysis were used to analyze the relationship between different expression levels of ECT2 or E2F1 and the survival of patients with OSCC in 3 years. Relative expression levels of E2F1 mRNA (1.31 ± 0.15) and ECT2 mRNA (3.95 ± 0.72) in OSCC tissues, compared to adjacent normal tissues (0.87 ± 0.11, 1.03 ± 0.23, all p < 0.05). ECT2 was highly expressed in 42 (60.00%) OSCC samples and E2F1 was highly expressed in 45 (64.29%) samples. The expression of ECT2 and E2F1 was related to clinical stage, lymphatic metastasis, tumor differentiation grade, and tumor diameter in OSCC patients. The higher the expression of ECT2 and E2F1, the lower the 3-year survival rate of patients. ECT2 high expression (HR=2.407, p < 0.001), E2F1 high expression of E2F1 (HR = 2.159, p = 0.013), Clinical stages (III+IV) (HR = 1.362, p = 0.012), medium and low differentiation (HR = 1.522, p = 0.015), lymphatic metastasis (HR = 1.951, p < 0.001), and tumor diameter (≥3 cm) (HR = 1.824, p = 0.002) could be independent factors for 3-year survival of patients with OSCC. The expression of ECT2 and E2F1 in OSCC was significantly up-regulated, which was closely related to clinical stage, lymph node metastasis, tumor size, and 3-year survival of OSCC patients.
Survival of a small reintroduced griffon vulture population in the Apennines: Insights from Global Positioning System tracking
Authors: Monti Flavio , Serroni Pietro , Rotondaro Francesco , Sangiuliano Alberto , Sforzi Andrea , Opramolla Giancarlo , Pascazi Antonello , Spacca Samuele , La Civita Filippo , Posillico Mario 
Published: October 2022

Conservation translocations ( e. g., restocking, reintroductions) represent efficient tools to prevent the extinction or favouring the return of previously extirpated populations into the wild. Evaluating demographic parameters of translocated populations is a key issue to assess and monitor their conservation status and to provide evidences useful to implement management actions aimed at long-term conservation results. We report first data on survival estimates and related mortality causes for a reintroduced population of Eurasian griffon vultures ( Gyps fulvus) in the central-southern Apennine, Italy, from satellite telemetry data. Twenty vultures have been fitted with solar-powered Global Positioning System (GPS) tags in Pollino National Park (PNP, southern Italy, N = 9) and Monte Velino Reserve (MVR, central Italy, N = 11). Survival has been estimated on a total amount of 173,568 GPS fixes from December 2016 to October 2020 (1415 days) using the Fleming-Harrington estimator. Five, out of 20 vultures, died by poisoning (40%), collision with wind turbines (20%) and of unknown causes (40%). Two birds dispersed from MVR to France (though they later came back) and one from PNP to Croatia. Estimated survival rate across the whole study period was 0.709 (±0.11, SE; 0.523–0.961, 95% CI), and annual survival rate was 0.915 (±0.06, SE; 0.846–0.990, 95% CI). No significant differences in survival rates have been detected according to sex or age. As mortality in our study was mainly human-caused, we urge relevant institutions and agencies to strengthen and effectively establish anti-poison strategies, as well as implementing mitigation and prevention measures for the existing and planned wind farms. The establishment of a long-term viable population in the central-southern Apennines will depend upon both lower levels of human-caused mortality and habitat preservation.
Effect of the Length of the Microcycle on the Daily External Load, Fatigue, Sleep Quality, Stress, and Muscle Soreness of Professional Soccer Players: A Full-Season Study
Authors: Oliva Lozano José M. , Muyor José M. , Pérez-Guerra Andrés , Gómez David , Garcia-Unanue Jorge , Sanchez-Sanchez Javier , Felipe José Luis 
Published: October 2022

Background: The aim of this study was to analyze the effect of the length of the microcycle (ie, training period from the day after the match to the following match) on the daily external load and perceived wellness of professional soccer players (Spanish LaLiga Smartbank). Hypothesis: The length of the microcycle has a significant effect on the daily external load and perceived wellness. Study Design: Longitudinal study. Level of Evidence: Level 3. Methods: Data were collected daily during a full season using perceived wellness questionnaires and electronic performance and tracking systems. Results: The length of the microcycle had a significant effect on volume- and intensity-related external load variables. There were differences between short, regular, and long microcycles depending on the day of the microcycle. These differences were observed in all external load variables. However, no significant differences between short, regular, or long microcycles were found on match day for any external load variable, except for high-intensity decelerations. Regarding the perceived wellness, the length of the microcycle had no effect on these variables, and there were no significant interactions between the length and the day of the microcycle. Conclusion: The length of the microcycle had a significant effect on volume- and intensity-related external load variables, but no significant effect on perceived wellness was observed. Clinical Relevance: These data may help strength and conditioning coaches understand that workload periodization should take this contextual variable into account, especially for external training load. In addition, this study may serve as a guide for practitioners to know the physical requirements of professional soccer players in Spanish LaLiga Smartbank, because the weekly external load profile and perceived wellness have been reported for different lengths of the microcycles. Thus, these data may be used for player load management.
Diabetes self-care activities and perception and glycemic control in adult Puerto Rican residents with Type 2 Diabetes: The LLIPDS Study
Authors: Llera-Fábregas Alejandro , Pérez-Ríos Naydi , Camacho-Monclova Dahianira M , Ramirez-Vick Margarita , Andriankaja Oelisoa M 
Published: October 2022

Background: Individuals with diabetes frequently have comorbid health conditions and suffer longer term complications. The control of blood glucose relies on diabetes management/self-care behaviors. Poor glycemic control, commonly encountered in underserved populations with type 2 diabetes (T2D) often results from inadequate diabetes self-care activities and/or perception. We aimed to assess the association between diabetes self-care activities/perception and glycemic control in adult Puerto Rican residents with T2D. Design and methods: We used a cross-sectional study design; our sample population was 260 individuals aged 40–65 years with T2D. We asked participants about their diabetes self-care over 8 weeks. High fasting blood glucose (≥130 mg/dL) and glycated hemoglobin (HbA1c; ≥7%) measures were defined. We estimated the strength of the following associations using logistic regression: each of three self-care activities and fasting glucose or HbA1c, adjusting for confounders. Results: Nearly 27% of the participants reported not checking their glucose levels, 7% did not take their medications as prescribed and 31% perceived their diabetes self-care as poor. Participants with less education perceived their diabetes self-care as poor more often than their counterparts (44% vs 25%; p = 0.003). Most participants had high glycemic levels (60%) or hbA1c levels (65%). Participants who perceived their diabetes self-care as poor had higher HbA1c levels than their counterparts (adj. odds ratio: 2.14, 95% CI (1.13, 4.08)). Conclusion: Poor diabetes self-care perception, possibly related to less education, likely explains poor glycemic control among adult Puerto Rican residents with T2D.
Subacute cognitive impairment after first-ever transient ischemic attack or ischemic stroke in young adults: The ODYSSEY study
Authors: Schellekens Mijntje MI , Boot Esther M , Verhoeven Jamie I , Ekker Merel S , van Alebeek Mayte E , Brouwers Paul JAM , Arntz Renate M , van Dijk Gert W , Gons Rob AR , van Uden Inge WM , den Heijer Tom , de Kort Paul LM , de Laat Karlijn F , van Norden Anouk , Vermeer Sarah E , van Zagten Marian SG , van Oostenbrugge Robert J , Wermer Marieke JH , Nederkoorn Paul J , van Rooij Frank G , van den Wijngaard Ido R , de Leeuw Frank-Erik , Kessels Roy PC , Tuladhar Anil M 
Published: October 2022

Introduction: We aimed to investigate the prevalence of cognitive impairment in the subacute phase after transient ischemic attack (TIA) and ischemic stroke (IS), factors associated with a vascular cognitive disorder, and the prevalence of subjective cognitive complaints and their relation with objective cognitive performance. Patients and methods: In this multicenter prospective cohort study, we recruited patients with first-ever TIA and IS, aged 18–49 years, between 2013 and 2021 for cognitive assessment up to 6 months after index event. We calculated composite Z-scores for seven cognitive domains. We defined cognitive impairment as a composite Z-score < −1.5. We defined major vascular cognitive disorder as a Z-score < −2.0 in one or more cognitive domains. Results: Fifty three TIA and 545 IS patients completed cognitive assessment with mean time to assessment of 89.7 (SD 40.7) days. The median NIHSS at admission was 3 (interquartile range, 1–5). Cognitive impairment was common in five domains (up to 37%), with similar proportion in TIA and IS patients. Patients with major vascular cognitive disorder had a lower education level, higher NIHSS scores and more frequent lesions in the left frontotemporal lobe than without vascular cognitive disorder ( p < 0.05 FDR-corrected). Subjective memory and executive cognitive complaints were present in about two-thirds of the patients, but were weakly associated with objective cognitive performance (β: −0.32 and −0.21, respectively). Discussion and conclusion: In the subacute phase after TIA or stroke in young adults, cognitive impairment and subjective cognitive complaints are prevalent, but they are weakly associated with each other.
Relationships Between Histopathological Findings in the Liver and Prognosis in Patients With Biliary Atresia
Authors: Higashio Atsushi , Yoshioka Takako , Kanamori Yutaka , Fujino Akihiro , Morotomi Yoshiki , Shibata Toshihiko , Nakaoka Tatsuo 
Published: October 2022

Background: Biliary atresia (BA) is a progressive obstructive hepatic disease that requires early diagnosis and the prompt initiation of treatment. Although portoenterostomy (PES) is usually performed as the initial surgical procedure, the liver damage may subsequently progress, such that liver transplantation (LTx) may be required. In this study, we comprehensively evaluated the histopathology of liver samples collected during PES and retrospectively evaluated its relationship with prognosis. Methods: Forty-seven patients with BA who underwent PES between 2002 and 2021 were included. Their biopsy samples were semi-quantitatively graded according to the severity of liver fibrosis, bile duct proliferation, cholestasis, ductal plate malformation, and inflammatory cell infiltration; and the expression of cluster of differentiation (CD)3, CD20, human leukocyte antigen II-DR, and α-smooth muscle actin (α-SMA). The relationships of each with the prevalence of survival with native liver (SNL) were evaluated to identify prognostic markers. Results: The median postoperative duration of follow-up was 11.8 years (maximum, 18.0 years; minimum, 3.5 years). There were no deaths during this period, but LTx was performed in 31 patients and the final prevalence of SNL was 34.0% (16/47). There were negative correlations of liver fibrosis and α-SMA with SNL, and a positive correlation between CD20 and SNL. Multivariate analysis using a proportional hazards regression model showed that only CD20 expression was significant. Conclusions: Comprehensive histopathological analysis of liver biopsy samples obtained at the time of PES showed a positive correlation between CD20 expression and SNL, suggesting that this may represent a useful prognostic marker. Level of evidence: III
Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications
Authors: Mladenov Mitko , Bogdanov Jane , Bogdanov Bogdan , Hadzi-Petrushev Nikola , Kamkin Andre , Stojchevski Radoslav , Avtanski Dimiter 
Published: October 2022

AbstractCurcumin is a polyphenolic compound derived from turmeric that has potential beneficial properties for cardiovascular and renal diseases and is relatively safe and inexpensive. However, the application of curcumin is rather problematic due to its chemical instability and low bioavailability. The experimental results showed improved chemical stability and potent pharmacokinetics of one of its analogs – (2E,6E)-2,6-bis[(2-trifluoromethyl)benzylidene]cyclohexanone (C66). There are several advantages of C66, like its synthetic accessibility, structural simplicity, improved chemical stability (in vitro and in vivo), presence of two reactive electrophilic centers, and good electron-accepting capacity. Considering these characteristics, we reviewed the literature on the application of C66 in resolving diabetes-associated cardiovascular and renal complications in animal models. We also summarized the mechanisms by which C66 is preventing the release of pro-oxidative and pro-inflammatory molecules in the priming and in activation stage of cardiomyopathy, renal fibrosis, and diabetic nephropathy. The cardiovascular protective effect of C66 against diabetes-induced oxidative damage is Nrf2 mediated but mainly dependent on JNK2. In general, C66 causes inhibition of JNK2, which reduces cardiac inflammation, fibrosis, oxidative stress, and apoptosis in the settings of diabetic cardiomyopathy. C66 exerts a powerful antifibrotic effect by reducing inflammation-related factors (MCP-1, NF-κB, TNF-α, IL-1β, COX-2, and CAV-1) and inducing the expression of anti-inflammatory factors (HO-1 and NEDD4), as well as targeting TGF-β/SMADs, MAPK/ERK, and PPAR-γ pathways in animal models of diabetic nephropathy. Based on the available evidence, C66 is becoming a promising drug candidate for improving cardiovascular and renal health.