bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
Authors: Giles Josephine R. , Ngiow Shin Foong , Manne Sasikanth , Baxter Amy E. , Khan Omar , Wang Ping , Staupe Ryan , Abdel-Hakeem Mohamed S. , Huang Hua , Mathew Divij , Painter Mark M. , Wu Jennifer E. , Huang Yinghui Jane , Goel Rishi , Wherry E. John 
Published: March 2022

AbstractNaïve CD8 T cells can differentiate into effector (TEFF), memory (TMEM), or exhausted (TEX) CD8 T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular circuitry underlying these developmental trajectories and the extent of heterogeneity within TEFF, TMEM, TEX populations remain poorly understood. Here, we used the lymphocytic choriomeningitis virus model of acutely-resolved and chronic infection and addressed these gaps by applying longitudinal scRNA-seq and scATAC-seq analysis. These analyses uncovered new subsets, including a subpopulation of TEX expressing NK cell-associated genes, as well as multiple distinct TCF1+ stem/progenitor-like subsets in acute and chronic infection. These data also revealed insights into the reshaping of TEX subsets following PD1 pathway blockade and identified a key role for the cell stress regulator, Btg1, in TEX differentiation. Finally, these results highlighted how the same biological circuits such as cytotoxicity or stem/progenitor pathways can be used by CD8 T cells with highly divergent underlying chromatin landscapes. Thus, this transcriptional and chromatin accessibility landscape map elucidates developmental biology and underlying mechanisms governing TEFF, TMEM, and TEX differentiation.
Females outperform males in spatial learning despite increased amyloid plaques and microgliosis in a TgF344-AD rat model of Alzheimer’s disease
Authors: Chaudry Osama , Ndukwe Kelechi , Xie Lei , Serrano Peter A. , Figueiredo-Pereira Maria E. , Rockwell Patricia 
Published: March 2022

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disease and is the sixth leading cause of death in the US. AD is more prevalent in females than males. While estrogen provides neuroprotection in females, sex mediated differences in the development of AD pathology are not fully elucidated. Therefore, a comparison of the events that develop between sexes in the early-stage of AD pathology may reveal new potential targets for more effective therapeutic intervention. To address sex differences, we analyzed early stage 9-month male and female TgF344-AD (Tg-AD) rats, an AD model carrying the APPswe and Presenilin 1 (PS1ΔE9) mutations that develops progressive age-dependent AD pathology similar to humans. Using active place avoidance (aPAT) tests that assess hippocampal-dependent spatial learning and memory, we found significant deficits in Tg-AD females compared to wild type females, but no significant difference between the two male genotypes. Moreover, significant sex differences were observed in that Tg-AD females outperformed Tg-AD males in several measures of the aPAT test. Unexpectedly, Tg-AD females displayed higher levels of hippocampal amyloid plaques and amoeboid microglia than their Tg-AD male littermates. Furthermore, Tg-AD females experienced less hippocampal neuronal loss and had higher GluA2 subunit levels than Tg-AD males. Based on our findings, we propose that estrogen may protect females against cognitive impairment at early stages of AD by regulating GluA2 levels independently of amyloid plaque deposition and gliosis. Elucidating this potential protective mechanism of action of estrogen in AD could lead to new targets for early intervention.
Stress during work placement – examining positive outcomes for hospitality students in a work-integrated learning programme
Authors: Ramgoolam-Atchiamith Anusha , Khan Aila , Rodrigues Cristina , Wardle Karina Michelle 
Published: March 2022

PurposeWork-integrated learning (WIL) is an integral part of hospitality curriculums in Australia. Experiencing stress during WIL is expected, as students try to balance work and other responsibilities. Previous studies have usually examined the negative impact of stress on individuals. By referring to relevant theories, this paper argues the positive impact of stress and reports on a study which aimed to investigate whether stress – experienced by students during WIL – leads to resilience and well-being.Design/methodology/approachHospitality students from different backgrounds enrolled at a tertiary institution completed an online survey. This study uses structural equation modelling (SEM), to test the proposed links between stress, resilience and well-being.FindingsThe study results show that “academic pressure” (mean score = 3.57) is the most common stressor identified by hospitality students. This was followed by stress caused by “time pressure” (mean score = 3.01). Model testing reveals that experiencing “career development concerns” has a statistically significant association with resilience. Moreover, there is a strong link (β = 0.624) between resilience and well-being.Originality/valueThis study makes a contribution by proposing positive outcomes related to stress during WIL. A handful of studies have looked at similar concepts. However, this paper uses statistical techniques to measure and analyse relationships between different variables. By running an SEM, the authors were able to test a linear causal relationship which identifies stressors leading to a significant impact on resilience. Similarly, the strength of relationship between resilience and well-being is also empirically tested.
Corporate internet reporting in Egypt: a pre- and peri-uprising analysis
Authors: Ahmed Ahmed Hassan , Elmaghrabi Mohamed , Burton Bruce , Dunne Theresa 
Published: March 2022

Purpose
The purpose of this study is to provide a detailed descriptive account and analysis of corporate internet reporting (CIR) practices among non-financial companies listed on the Egyptian Exchange (EGX) at two points in time – December 2010 (pre) and December 2013 (peri) political and social unrest in Egypt.

Design/methodology/approach
The study developed a disclosure index to determine the extent of CIR practices among all non-financial companies listed on the EGX in December 2010 and December 2013. The study uses ordinary least squares (OLS) regressions and isometric log-ratio transformations for compositional independent variables to empirically examine the factors affecting CIR in Egypt using a modern institutional theory lens.

Findings
The findings of this investigation suggest that listed companies in Egypt have started embracing the power of the internet as a disclosure channel, but the extent of these practices increased significantly over the investigated period, with great variations evident among the sampled companies in this regard. Such variations were chiefly dependent on the changing institutional actors over the two time frames. Additionally, the findings show that the time factor is particularly important for a given institutional field to induce a sufficient diffusion of corporate practices, especially in periods with drastic institutional change.

Practical implications
The evidence presented reflects the voluntary nature of CIR practices and the absence of a reinforced regulatory framework for organizing and monitoring such practices, with companies having discretion in terms of the amount and type of information disclosed via their websites. The results should, therefore, provide useful guidelines for regulators and standard-setters in identifying best practices, which, in turn, should allow CIR practices to become more consistent, making them easier to monitor and govern.

Originality/value
To the best of the authors’ knowledge, this is the first study that examines CIR practices at two points in time using a comprehensive disclosure index and a modern institutional theory lens.
Are university “living labs” able to deliver sustainable outcomes? A case-based appraisal of Deakin University, Australia
Authors: Martek Igor , Hosseini M. Reza , Durdyev Serdar , Arashpour Mehrdad , Edwards David J. 
Published: March 2022

Purpose
Universities have recognized their rich endowments in research, academic skills and facilities, as uniquely suited to finding “green” solutions. Moreover, the campus setting itself presents as a microcosm of greater society through which to investigate and test innovations. Thus, the “living lab” was born, a means of coupling sufficient resources and active stakeholders in the pursuit of practical, sustainable solutions. Much of the work to date, however, remains piecemeal, small-scale and disparate. This study aims to propose that the work of such labs must ultimately be directed, coordinated and integrated under a “university sustainability office,” if they are to be ultimately effective.

Design/methodology/approach
The research approach is twofold. In the first instance, a literature review charting the history and progress of living labs is reported, with emphasis of the university context. Second, a case study appraisal of Deakin University’s initiatives in adopting and promoting sustainability through the living lab framework is undertaken.

Findings
A main finding of this paper is that current efforts remain piecemeal and peripheral. If the apparent ambiguity regarding commitment is to be overcome, Deakin University should adopt measures as adopted by peer leaders in the field. Specifically, the setting up of a centralizing sustainability function bestowed with the capacity to coordinate university-wide living lab efforts, and at such a scale that substantial benefits transferable to greater society is generated.

Originality/value
This paper stands out among previous studies in the field through facilitating a transition to living lab for other universities, where findings facilitate that progress and consider how the lessons learnt might inform the further evolution of university living lab initiatives.
Factors affecting users’ stickiness of fitness apps: an empirical study based on the S-O-R perspective
Authors: Teng Xianzhong , Bao Zheshi 
Published: March 2022

PurposeDespite fitness applications (apps) are increasingly downloaded by smartphone users in recent years, the usage behavior after initial adoption often lasts for a short period of time for most users. The purpose of this paper is to explore factors affecting stickiness of fitness app and then indicate how to retain existing users.Design/methodology/approachA research model was developed based on stimulus–organism–response (S-O-R) model. Using the data collected from 231 fitness app users through an online survey, the established model was empirically assessed by structural equation modeling (SEM).FindingsThe results show that human-to-information interaction and human-to-human interaction as environmental stimuli affect individuals' internal state, including social comparison and perception of fitness self-management, which consequently influence the stickiness of fitness apps.Originality/valueThe study provides new insights into the mechanism regarding why users are willing to continuously use fitness apps. Moreover, the understanding of social comparison among users in such process was also deepened.
Governance structures and price volatility perceptions in the Indonesian chilli value chain
Authors: Muflikh Yanti Nuraeni , Adhikari Rajendra , Abdul Aziz Ammar 
Published: March 2022

PurposeThis paper aims to analyse the governance structures of the Indonesian chilli value chain, price volatility issues across the chain and to critically explore the value chain actors' perceptions and responses to price volatility.Design/methodology/approachThe authors used semi-structured interviews with 148 primary actors of the Indonesian chilli value chain. In-depth interviews with 22 key stakeholders – from local, provincial and national levels – were conducted in order to obtain additional information about their roles and the current policies and challenges in the chilli industry. The authors also conducted focus group discussions (FGDs) with farmers and support providers and held a national workshop to gather governance and price volatility risk-related information.FindingsThe Indonesian chilli value chains are long, complex and involve multiple actors. Most relationships within the value chains are based on market governance in which price regulates transactions. Most value chain actors shared a similar perception of price volatility and its causes. Under different governance structures, the value chain actors identified production, product characteristics and marketing as a major cause of price volatility. Although strategies applied by the value chain actors varied, in the main they are all aimed at minimising the impact of price volatility. Contractual arrangements are viable alternatives to minimising price risk.Research limitations/implicationsThis research relies primarily on qualitative data derived from purposive data collection methods, which may reduce the ability to generalise the findings. A quantitative analysis is required to validate the level of price volatility perceived by the stakeholders and to assess the cause and impact of price volatility across the chain. Future research should focus on proposing and assessing potential policy interventions that address price volatility, in order to facilitate the development of the Indonesian chilli industry.Originality/valueTo the best of the author’s knowledge, this study is the first to investigate the governance structures of the Indonesia chilli value chain, the value chain actors' perceptions of price volatility and their responses under the different types of governance in a developing country context.
Native advertising relevance effects and the moderating role of attitudes toward social networking sites
Authors: Yoon Hye Jin , Huang Yan , Yim Mark Yi-Cheon 
Published: March 2022

PurposeNative advertising on social media continues to be a popular ad placement for marketers. With native ad-content relevance in need of further exploration regarding individual differences and social media public sentiment waning, this study set out to test the effects of ad-content relevance of native ads varying by users' pre-existing social networking site (SNS) attitude.Design/methodology/approachTwo experiments were conducted with native ads relevant and irrelevant to the surrounding media content with SNS attitude as a measured moderator and perceived ad importance as the mediator.FindingsAcross Instagram and Twitter, SNS attitude moderated the effect of ad relevance on ad responses. Users that had lower SNS attitudes had significantly higher ad ratings that were relevant (vs. irrelevant) to the media content, while those that had higher SNS attitudes did not show differences. The lower SNS attitude individuals showed a greater appreciation for the relevant ads through the mediating effect of perceived importance.Practical implicationsMarketers need to look beyond traditional ad attitude models and craft ad content strategies that consider target audiences' SNS preferences. Layering targeting tactics on Instagram and Twitter such as “interests” and “life events” with demographic targeting could help increase the chances of ad-content relevance. SNSs should advance their ad placement tools and utilize image, speech, and text recognition algorithms to help achieve ad-content relevance for greater ad effectiveness.Originality/valueThis study adds to the literature by identifying SNS attitude as a qualifier of ad-content relevance effect for SNS native ads and uncovering perceived ad importance as the underlying psychological mechanism.
Designing a collection tree using Omeka
Authors: Mandal Sukumar 
Published: March 2022

Purpose
The purpose of this study is to look into the three major new innovative components such as collection tree, tags cloud and geolocation for developing digital library system. This study aims to develop and design an integrated framework for enhancing this services.

Design/methodology/approach
This study will develop a single purpose-driven framework for the domain. It will vary user-friendly architecture on expanding the collection tree based on a high-level operating system and plugins. Now software programs are available in the Omeka Web repository. The whole integrated framework has been designed based on the Linux Operating platform and LAMP architecture towards depends on proper installation and configuration of the “Collection Tree” module with Omeka for both the administration and user interfaces.

Findings
With this integrated structure, keyword cloud users will have easy access to objects and full-text content. Because it can save readers time, the collection tree is helpful in them. This integrated framework for constructing and designing the collection tree for the digital library allows geolocation-based searches from multiple collections.

Originality/value
The integrated domain-specific framework has been designed and developed for the libraries. So, it is feasible to provide better library services in inter-operability and crosswalk through the Omeka collection tree interface. It increases the advanced search mechanism for users using this innovative module and techniques towards creating collection trees based on tag clouds and geolocation for library professionals and advanced level users from multiple collections of hierarchy.
Financing Approaches to Social Prescribing Programs in England and the United States
Authors: SANDHU SAHIL , ALDERWICK HUGH , GOTTLIEB LAURA M. 
Published: March 2022

Policy Points
The number of social prescribing practices, which aim to link patients with nonmedical services and supports to address patients’ social needs, is increasing in both England and the United States.
Traditional health care financing mechanisms were not designed to support social prescribing practices, and flexible payment approaches may not support their widespread adoption.
Policymakers in both countries are shifting toward developing explicit financing streams for social prescribing programs. Consequently, we need an evaluation of them to assess their success in supporting both the acceptance of these programs and their impacts.
Investment in community‐based organizations and wider public services will likely be crucial to both the long‐term effectiveness and the sustainability of social prescribing.
Psychopathic femicide: The influence of psychopathy on intimate partner homicide
Authors: Santos‐Hermoso Jorge , González‐Álvarez José Luis , López‐Ossorio Juan José , García‐Collantes Ángel , Alcázar‐Córcoles Miguel Ángel 
Published: March 2022

AbstractHigh scores in psychopathy were associated with acts of violence, and the prevalence of this condition is greater among the prison population than among the general population. In terms of its relation to femicide, two studies, one carried out in Sweden and another in Spain with a prison population, found that psychopathy is an uncommon condition among perpetrators of femicide. This study analyzes 97 cases of femicide in the whole of Spain, in which it was possible to evaluate the degree of psychopathy of the perpetrators using the Psychopathy Checklist‐Revised (PCL‐R). The scores are analyzed not only directly, but also in terms of Factors and Facets. The results show an average in the total score of the PCL‐R of 14.4, with only 13 subjects (13.4%) presenting scores of 25 or more, and just 3 (3.1%) of these presenting scores of 30 or higher. It was found that, in general, high scores in psychopathy are associated with shorter relationships and less time between the first complaint, the breakup, and the femicide. What is more, characteristics of the victims, such as addiction to toxic substances or economic dependency, also demonstrated a relationship to the scores of the perpetrators of femicide in the PCL‐R. Lastly, it was found that the scores in the different dimensions of psychopathy are associated with different types of violence, whereby there was a noteworthy difference between the most explicit violence and control exercised over the partner.
Remembering Sir David Cox, 1924–2022
Authors: Firth David , Reid Nancy , Mayo Deborah G. , Battey Heather 
Published: March 2022

Abstract
Sir David Cox died on 18 January 2022 at the age of 97. News of his passing was met with an outpouring of tributes. To the Royal Statistical Society, he was “one of the most important statisticians of the past century”. At Nuffield College, Oxford, he was hailed as “a pioneering statistician”. The MRC Biostatistics Unit at Cambridge called him “a giant in the field”, while at St John's College, Cambridge, he was celebrated as “an inspiring scholar”. In this special collection of articles, friends and colleagues remember Sir David in their own way, while also reflecting on his immense contributions to statistics
An exploratory study of industry perspectives to inform undergraduate nutrition employability initiatives
Authors: Croxford Sharon , Stirling Emma , McLeod Susan , Biesiekierski Jessica , Murray Emily , Ng Ashley H. , Bramley Andrea , Forsyth Adrienne 
Published: March 2022

AbstractAimThe aim of this study was to explore nutrition professionals' perspectives of nutrition graduates' employability skills, and knowledge and skills required in the industry to understand gaps in undergraduate nutrition curriculum.MethodsNutrition professionals (n = 26) across Australia were approached to participate in semi‐structured interviews via telephone in 2018. Interviews were transcribed verbatim, data analysed using thematic analysis, and results interpreted and discussed.ResultsNine participants across six work environments completed interviews. Common work roles were identified in their diverse areas of practice: nutrition educators, food developers, team members, and business leaders. Nutrition professionals identified that, in addition to evidence‐based discipline knowledge, key skills and knowledge needed for their roles were interpersonal communication, including writing and listening. Participants highlighted the need for employability skills to be embedded within curriculum with emphasis on professional skills, business skills and discipline‐specific skills in communicating complex science messages to a range of audiences. Networking, and formal and informal work‐integrated learning were viewed as important vehicles for developing required skills. Participants expected that universities develop curriculum to address gaps; however, reflection by the academic researchers suggested this should be a joint role.ConclusionsEarly career planning, professional skill development, work experience and networking opportunities should enhance graduate employability.