bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbonatite-melilitite-phosphate immiscible melts from the aragonite stability field entrained from the mantle by a Pliocene basalt
Authors: Hurai Vratislav , Huraiová Monika , Habler Gerlinde , Horschinegg Monika , Milovský Rastislav , Milovská Stanislava , Hain Miroslav , Abart Rainer 
Published: June 2022

AbstractA plagioclase megacryst containing composite crystal-glass inclusions was ejected in a Pliocene basaltic diatreme in the Carpathian back-arc basin (Pannonian Basin). The megacryst grew from phonolitic melt, relics of which are preserved in the crystal-glass inclusions. Most of the pristine melt has undergone substantial compositional resetting by interaction with several batches of a low-viscosity carbonated, P-rich melilitite melt, which infiltrated and largely replaced the original inclusion content. The melilitite melt also caused partial resorption of the host megacryst and crystallisation of new calcic plagioclase forming stringers and palisades. A P-rich calcic carbonatite melt exsolved from the melilitite and later crystallised to aragonite at ~ 800 °C and 1.9 GPa. The phosphate melt fraction exsolved from the carbonatite and solidified as CO32−-rich A-B type apatite. At a very late evolutionary stage, K- and Si-rich fluids caused potassic and silicic alteration of the solidified melilitite glass along cracks and interfaces between calcic carbonate globules and glass at temperatures below 680 °C. The oxygen isotope composition of the plagioclase megacryst (6.2 ‰ V-SMOW; Vienna Standard Mean Ocean Water) and the 87Sr/86Sr isotope ratio of carbonates in the inclusions (0.7034) are consistent with a mantle-derived melt. 87Sr/86Sr isotope ratios (0.7047–0.7051) in interstitial carbonates from associated syenite and carbonatite xenoliths indicate a metasomatised mantle source contaminated with radiogenic crustal material or altered marine carbonate. The O-isotope ratios in the carbonates, 22.7 ± 0.6 ‰ V-SMOW in calcite and 23.6 ± 0.7 ‰ V-SMOW in aragonite, are also consistent with a sedimentary precursor. Contrasting δ13C values in the calcite, -12.7 ± 0.5 ‰ V-PDB (Vienna PeeDee Belemnite), and the aragonite (-4.6 ± 0.5 ‰ V-PDB) indicate low-temperature modification of calcite assisted by $$\delta$$
δ
13C-depleted CO2 and preservation of primary magmatic $$\delta$$
δ
13C values in aragonite. The microstructural and geochemical evidence points towards heterogeneous silicate-carbonate melt fractions generated during the metasomatism and partial melting of a supra-subduction mantle wedge.
Multi-analyte HPLC–DAD Method for Concurrent Analysis of Six Antimicrobials and Three Proton Pump Inhibitors Frequently used in Management of Helicobacter pylori Infection: Application to Simulated Intestinal Fluid Samples
Authors: Gawad Dina A. , Elnaggar Mai M. , Belal Tarek S. 
Published: June 2022

AbstractThe present work deals with the optimization, validation and application of a versatile HPLC–DAD method for concurrent estimation of nine antimicrobials and proton pump inhibitors, namely amoxicillin (AMX), doxycycline (DOX), furazolidone (FRZ), lansoprazole (LNS), levofloxacin (LVF), metronidazole (MTZ), omeprazole (OMZ), pantoprazole (PNZ) and tinidazole (TNZ). The selected nine drugs are frequently included in various treatment regimens of Helicobacter pylori infection. Successful separation was accomplished using the analytical column Agilent Zorbax Eclipse plus-C18 (250 × 4.6 mm, 5 µm particle size) and a mobile phase prepared from phosphate buffer pH 5 and acetonitrile pumped at a flow rate 1 mL/min using a gradient elution program. The gradient elution started with buffer/acetonitrile ratio 90:10, then it was altered in 15 min to reach 40:60 by volume. Quantification of the analytes was based on measuring peak areas of AMX at 230 nm, LVF, LNS and PNZ at 290 nm, OMZ at 300 nm, MTZ and TNZ at 320 nm, and DOX and FRZ at 360 nm. The separated compounds eluted at retention times 5.68, 6.43, 7.82, 8.84, 9.42, 10.75, 12.82, 13.74 and 14.90 min for AMX, MTZ, LVF, TNZ, DOX, FRZ, OMZ, PNZ and LNS respectively. Validation of the proposed HPLC procedure was carefully studied according to the ICH items: ranges, precision, accuracy, linearity, robustness and limits of detection and quantitation. The linear dynamic ranges were 5–100, 5–50, 2–40, 10–100, 10–100, 5–50, 2.5–30, 3–30 and 2–30 µg/mL for AMX, MTZ, LVF, TNZ, DOX, FRZ, OMZ, PNZ and LNS, respectively with correlation coefficients > 0.9993. Application fields of the validated method included analysis of laboratory-prepared binary dosage forms along with analysis of several ternary mixtures in spiked simulated intestinal fluid.
Assessing the risk of establishment and transient populations of Spodoptera frugiperda in Europe
Authors: Gilioli Gianni , Sperandio Giorgio , Simonetto Anna , Ciampitti Mariangela , Gervasio Paola 
Published: June 2022

AbstractThe fall armyworm, Spodoptera frugiperda (J.E. Smith), is an invasive pest threatening crop production and food security worldwide. High concerns are linked to the potential establishment of the species in Europe. The high migratory capacity of S. frugiperda causes concerns about the potential impacts of transient populations invading new areas from suitable hotspots. In the present work, we developed and used a physiologically-based demographic model to quantitatively assess the risks of S. frugiperda in Europe. The risks were assessed considering a best-, a median-, and a worst-case scenario. The Mediterranean coastal areas of Southern Europe resulted particularly suitable for the establishment of the species, with suitable areas reaching even higher latitudes, in the worst-case scenario. In Europe, up to four generations per year were predicted. The predicted yearly average number of moths per trap per week (± standard deviation) was 5 (± 4), 17 (± 5), and 139 (± 22) in the best, median-, and worst-case assessment scenarios, respectively. Model results showed that Southern and Central Europe up to the 48th parallel north might be exposed to the risk of transient populations. Depending on the latitude and on the period of arrival of the propagule, 1–2 transient generations per year might be expected. The model can be used to define strategies for reducing the risks of establishment of the pest at the country level. Predictions on the dynamics and phenology of the pest can also be used to support its management at the local level.
Arenas of Contestation: A Senian Social Justice Perspective on the Nature of Materiality in Impact Measurement
Authors: Lehner Othmar Manfred , Nicholls Alex , Kapplmüller Sarah Beatrice 
Published: June 2022

Abstract

Although the importance of measuring and reporting the social and environmental impact of organisational action is increasingly well recognised by both organisations and society at large, existing approaches to impact measurement are still far from being universally accepted. In this context, the stakeholder dynamics within the nascent field of impact investing demonstrate the complexity of resolving potentially differing perspectives on key impact measurement issues such as materiality. This paper argues, from an organisational perspective, that such arenas of contestation can be conceptualised in terms of social justice. Specifically, we draw upon Sen’s notions of ‘arrangement and realisation’ to explore the dynamics of contestation across a range of stakeholders concerning materiality judgements to suggest that such ‘arrangements’ may lead to suboptimal impact outcomes as ‘realisations.’ Our analysis of the nature of materiality contestations in impact measurement reveals the conflicts, tensions and paradoxes evident in this field of action. Empirically, we examine data drawn from 19 cases and 33 interviews. The analysis suggests three arenas of contestation around the materiality of impact measurement: the power dynamics between economically powerful investors and objectified investees; the conflicts between materiality norms and standards; and the interactions between all stakeholders with differing motivations towards radical or incremental materiality. Building upon this analysis, we then discuss how arenas of contested materiality may be mediated by drawing upon Sen’s notions of transcending the individual interests of the invested parties for the greater good via processes of contextualisation and case-specificity.
Effects of resistance training on body composition and physical function in elderly patients with osteosarcopenic obesity: a systematic review and meta-analysis
Authors: Yang Jia-ming , Ye Hua , Zhu Qiang , Zhang Jia-hong , Liu Qin-qin , Xie Hui-yong , Long Yi , Huang Hui , Niu Yan-long , Luo Yun , Wang Mao-yuan 
Published: June 2022

Abstract

Summary

Osteosarcopenic obesity (OSO) is a complex disease commonly seen in the elderly. We found that resistance training may improve bone mineral density, skeletal muscle mass, and body fat percentage in patients with OSO. Therefore, resistance training is beneficial for elderly OSO patients and is worth being promoted.

Purpose
Investigate effects of resistance training on body composition and physical function in elderly osteosarcopenic obesity (OSO) patients.

Methods
PubMed, Web of Science, Embase, Cochrane Library, Medline, SinoMed, CNKI, and Wanfang Database were searched from inception until October 13, 2021.Two independent researchers extracted the key information from each eligible study. The methodological quality of included studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. The Cochrane Risk of Bias Tool was used to assess the risk of bias. Grading of Recommendations Assessment Development and Evaluation (GRADE) was used to evaluate the quality of the outcomes. Sensitivity analysis indicated the stability of the results. Statistical analysis was performed using Review Manager 5.3.

Results
Four randomized controlled studies meeting the inclusion criteria were included, with 182 participants. Twelve weeks of resistance training improved bone mineral density (BMD, mean difference (MD) = 0.01 g/cm2, 95% confidence interval (CI): 0.001, 0.02, P = 0.03, I2 = 0%), skeletal muscle mass (SMM, MD = 1.19 kg, 95% CI: 0.50, 1.89, P = 0.0007, I2 = 0%), Z score, timed chair rise test (TCR), and body fat percentage (BFP, MD =  − 1.61%, 95% CI: − 2.94, − 0.28, P = 0.02, I2 = 50%) but did not significantly affect skeletal muscle mass index (SMI, MD = 0.20 kg/m2, 95% CI: − 0.25, 0.64, P = 0.38, I2 = 0%) or gait speed (GS).

Conclusions
Resistance training is a safe and effective intervention that can improve many parameters, including BFP, SMM, and Z score, among OSO patients and is a good option for elderly individuals to improve their physical fitness.
A Pilot Randomized Controlled Trial Investigating MBSR for Parkinson’s Disease Patients and Their Caregiving Partners: Effects on Distress, Social support, Cortisol, and Inflammation
Authors: Siwik Chelsea J. , Phillips Kala , Litvan Irene , Salmon Paul , Rodgers Allison , Jablonski Megan , Sephton Sandra E. 
Published: June 2022

AbstractObjectivesTo examine the preliminary effects of the mindfulness-based stress reduction (MBSR) program in the management of biopsychosocial stress–related changes associated with Parkinson’s disease (PD) among patient/caregiving-partner dyads.MethodsPD patient/caregiving-partner dyads (N = 18) early in the disease trajectory were recruited from a university-affiliated movement disorders clinic and were randomized (1:1) to either the MBSR intervention or the control condition (treatment as usual [TAU]). Mixed methods ANOVAs were conducted to examine primary outcomes (disease-specific distress, perceived social support, circadian rhythmicity [cortisol], and markers of inflammation [IL-6, TNF-alpha, IL-1beta]) between groups (MBSR vs. TAU) among patients and caregiving partners separately.ResultsNo participants were lost to follow-up. Given the pilot nature of the current investigation, findings should be interpreted as exploratory opposed to confirmatory. Following MBSR, PD patients reported an increase in disease-specific distress and intrusive thoughts and demonstrated a decrease in mean bedtime cortisol and IL-1beta from baseline to follow-up compared to TAU. Caregiving partners who received MBSR reported an increase in perceived social support and demonstrated improved rhythmicity of diurnal cortisol slopes from baseline to follow-up compared to TAU.ConclusionsBoth patients and caregiving partners who received MBSR demonstrated improvements in biomarkers of circadian function, and patients evidenced a decrease in a biomarker of systemic inflammation, pointing to an important area of further investigation. Given that patients reported an increase in disease-specific distress and intrusive thoughts, the salutary effects of MBSR may be experienced physiologically prior to, or in lieu of, psychological effects, although this should be explored further, especially given the improvement in perceived social support reported by caregiving partners.
Groundwater contamination in public water supply wells: risk assessment, evaluation of trends and impact of rainfall on groundwater quality
Authors: Nemčić-Jurec Jasna , Ruk Damir , Oreščanin Višnja , Kovač Ivan , Ujević Bošnjak Magdalena , Kinsela Andrew Stephen 
Published: June 2022

AbstractThis study investigates the risk to contamination of groundwater in public water supply wells in the Koprivnica-Križevci county (northwest Croatia). Five physicochemical parameters were monitored in all groundwater samples from 2008 to 2017 to identify major differences between the wells, assess temporal variations and understand the capacity for rainfall to alter groundwater pollution loadings. Multivariate discriminant analysis showed statistically significant differences between the six sampled wells based on the analyzed parameters (Wilks' lambda: 0.001; F = 26.2; p < 0.0000). Principal component analysis revealed two significant factors, including factor 1 which explained 32.8% of the variance (suggesting that the quality of the groundwater was mainly controlled by nitrate) and factor 2, accounting for 16.2% of the total variance (which corresponded to KMnO4/oxidizability and to a lesser extent, pH). The time series data showed disparate trends, with nitrate concentrations increasing, whereas pH and KMnO4 decreased, while electrical conductivity and chloride levels remained stable. Although rainfall can impact groundwater pollution loadings through dilution processes in aquifers, the resulting fluctuations in physicochemical parameters are complicated by variations in rainfall events and local topography, as well as from climate change. Therefore, it is important to predict the contamination of groundwater quality in the future using machine learning algorithms using artificial neural network or similar methods. Multivariate statistical techniques are useful in verifying temporal and spatial variations caused by anthropogenic factors and natural processes linked to rainfall. The resulting identified risks to groundwater quality would provide the basis for further groundwater protection, particularly for decisions regarding permitted land use in recharge zones.
Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release
Authors: Wei Qiangbing , Fu Tian , Lei Lele , Liu Huan , Zhang Yixin , Ma Shuanhong , Zhou Feng 
Published: June 2022

AbstractOsteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA—PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA—PSPMA). The as-prepared h-SiO2/PDA—PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA—PSPMA coating and “rolling” effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA—PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA—PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.
Investor Heterogeneity and Liquidity
Authors: Chan Kalok , Cheng Si , Hameed Allaudeen 
Published: June 2022

AbstractFund flows are more correlated among funds with similar investment horizon, consistent with correlated demand for liquidity. We find that stocks held by institutions with more heterogeneous investment horizon are more liquid and have lower volatility of liquidity. Identification tests confirm that the improvement in stock liquidity holds when the increase in investor heterogeneity arises from an exogenous shock due to the 2003 tax reform. In addition, extreme flow-induced trading by institutional funds has a bigger price impact when stocks have a less heterogeneous investor base. Moreover, the premium associated with stock illiquidity is concentrated in stocks with low investor heterogeneity.
Staging of unipolar depression: systematic review and discussion of clinical implications
Authors: Cosci Fiammetta , Fava Giovanni A. 
Published: June 2022

AbstractStaging has been increasingly used in unipolar depression since its introduction in the nineties. Several models are available, but their differential features and implications are not completely clear. We systematically reviewed: (a) staging models of longitudinal development of unipolar depression; (b) staging models of treatment-resistant unipolar depression; (c) their applications. MEDLINE, PsycINFO, EMBASE, and Web of Science were examined according to PRISMA guidelines from inception to December 2021. Search terms were: ‘stage/staging’, combined using the Boolean ‘AND’ operator with ‘psychiatric disorder/mental disorder/depressive/mood disorder’. A total of 169 studies were identified for inclusion: 18 described staging models or applications, 151 described treatment-resistant staging models or applications. Staging models of longitudinal development were found to play a key role in formulating sequential treatment, with particular reference to the use of psychotherapy after pharmacotherapy. Staging methods based on treatment resistance played a crucial role in setting entry criteria for randomized clinical trials and neurobiological investigations. Staging is part of clinimetrics, the science of clinical measurements, and its role can be enhanced by its association with other clinimetric strategies, such as repeated assessments, organization of problematic areas, and evaluation of phenomena that may affect responsiveness. In research, it may allow to identify more homogeneous populations in terms of treatment history that may diminish the likelihood of spurious results in comparisons. In clinical practice, the use of staging in a clinimetric perspective allows clinicians to make full use of the information that is available for an individual patient at a specific time.
Single ventricle palliation of truncus arteriosus with mitral atresia, interrupted aortic arch, and aberrant right subclavian artery
Authors: Pizarro Christian , Shillingford Amanda J. , Pizarro Sebastian D. , Beaty Claude A. 
Published: June 2022

AbstractThe association of truncus arteriosus communis with interrupted aortic arch and mitral atresia is an exceptionally rare congenital defect. We describe the initial decision-making and management of this lesion, which eventually achieved a Fontan palliation.
SGLT2 inhibitor activates the STING/IRF3/IFN-β pathway and induces immune infiltration in osteosarcoma
Authors: Wu Wei , Zhang Zhenhao , Jing Doudou , Huang Xin , Ren Dianyun , Shao Zengwu , Zhang Zhicai 
Published: June 2022

AbstractSGLT2 (sodium-glucose cotransporter 2) is an important mediator of epithelial glucose transport and has been reported that SGLT2, robustly and diffusely expressed in malignant cancer cells, was overexpressed in various tumors, and inhibiting the SGLT2 expression significantly inhibited tumor progression. By blocking the functional activity of SGLT2, SGLT2 inhibitors have shown anticancer effects in several malignant cancers, including breast cancer, cervical cancer, hepatocellular cancer, prostate cancer, and lung cancer. However, the anticancer effect of SGLT2 inhibitors in osteosarcoma and the specific mechanism are still unclear. In the present study, we found that SGLT2 was overexpressed at the protein level in osteosarcoma. Furthermore, our results showed that the SGLT2 inhibitor significantly inhibited osteosarcoma tumor growth and induced infiltration of immune cells in vivo by upregulating STING expression and activating the IRF3/IFN-β pathway, which could attribute to the suppression of AKT phosphorylation. In addition, the combined treatment with SGLT2 inhibitor and STING agonist 2’3’-cGAMP exerted synergistic antitumor effects in osteosarcoma. Furthermore, the overexpression of SGLT2 at the protein level was correlated with the degradation of SGLT2 induced by TRIM21. This result demonstrated that SGLT2 is a novel therapeutic target of osteosarcoma, and that the SGLT2 inhibitor, especially in combination with 2’3’-cGAMP, is a potential therapeutic drug.
High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
Authors: Ronteix Gustave , Jain Shreyansh , Angely Christelle , Cazaux Marine , Khazen Roxana , Bousso Philippe , Baroud Charles N. 
Published: June 2022

AbstractCytotoxic T cells are important components of natural anti-tumor immunity and are harnessed in tumor immunotherapies. Immune responses to tumors and immune therapy outcomes largely vary among individuals, but very few studies examine the contribution of intrinsic behavior of the T cells to this heterogeneity. Here we show the development of a microfluidic-based in vitro method to track the outcome of antigen-specific T cell activity on many individual cancer spheroids simultaneously at high spatiotemporal resolution, which we call Multiscale Immuno-Oncology on-Chip System (MIOCS). By combining parallel measurements of T cell behaviors and tumor fates with probabilistic modeling, we establish that the first recruited T cells initiate a positive feedback loop to accelerate further recruitment to the spheroid. We also provide evidence that cooperation between T cells on the spheroid during the killing phase facilitates tumor destruction. Thus, we propose that both T cell accumulation and killing function rely on collective behaviors rather than simply reflecting the sum of individual T cell activities, and the possibility to track many replicates of immune cell-tumor interactions with the level of detail our system provides may contribute to our understanding of immune response heterogeneity.