bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Stability of Cefamandol and Ceftazidime with Clavulanic Acid Against Extended Spectrum ?- Lactamase
Authors: S. Shaokat Siham , A. Hameed Hamoudi 
Published: March 2022

The aim of this study is to evaluate in-vitro activity of Cefamandol (Cfm) and Ceftazidime (Cfz), in combination with Clavulanic acid (CA) against ten complicated multiresistant uropathogenic E.coli .One hundred clinical strains were isolated from patients with chronic urinary tract infections (UTIs), these isolates were identified by the Api identification systems. The antimicrobial susceptibility tests were determined by Kirby-Bauer method, all of them were sensitive to Imipenem (Imp). Ten strains were chosen for the present study, they were resistant to Ampicillin (Amp), Amoxicillin (Amo), Carbenicillin (Cb), Ticarcillin (Tic), Azlocillin (Azl), Amoxicillin\ Potassium Clavulanate {Augmentin(Amc)}, (Amo\CA), Ticarcillin\ Potassium Clavulanate {Timentin} (Tic\CA) ,Cefazolin (Cfo) ,Cefaloridin (Cfr), Cefamandol, (Cfm),Cefoxitin, Ceftazidime (Cfz), Cefixime (Cxm), Cefoperazone( Cfp) and Aztreonam (Atm), also resistant to other antibiotics, Tetracycline(Tc),Cloramphenicol(Cm),Gentamycin(G),Amikacin (Amk), Ciprofloxacin (Cip) and Trimethoprim. 50% of the isolates were resistant to Nalidixic acid and Rifampicin. The minimum inhibitory concentrations of Cefamandol and Ceftazidime were determined, by tube method. Transfer of plasmids were done by direct conjugation test to sensitive standard E.coli ,cell free Î²- lactamases were prepared and detected by macro-iodometric method. The activity of each cell free ÃŸâ€“ lactamases extract against Cfm and Cfz were determined by disks diffusion method (microbiological Masuda method). Excellent activities were obtained against these strains when Cfm and Cfz, combined with CA, therefore complete zones of inhibition were obtained indicated the prevalence of extended spectrum Î²- lactamases in E.coli. The stability of Cfm and Cfz in the presence of CA were useful in the treatment of chronic urinary tract infections caused by multiresistant Î²- lactamase (ESBL) producer E.coli.
Key words: Extended spectrum Î²- lactamases, Imipenem, Aztreonam, Ceftazidime.
ІНФОРМАЦІЙНЕ МОДЕЛЮВАННЯ В ПРОЦЕСАХ ІНФОРМАЦІЙНОГО ЗАБЕЗПЕЧЕННЯ ОРГАНІЗАЦІЇ
Authors: Laba O. , Romanyshyn Yu. 
Published: March 2022

<p><strong><em>The purpose</em></strong><em> of the research is to build an information model of information resources of the institution for the vehicle drivers training, to analyze the effectiveness of the information resources use in the context of information support for driver training. </em></p><p><strong><em>Research methodology.</em></strong><em> To build an information model of information resources of the institution for the vehicle drivers training the following methods were used: analysis, description, generalization, classification, information modeling. </em></p><p><strong><em>Results.</em></strong><em> The information resources used in the activities of the institution for the vehicle drivers training were analyzed. The information resources of the institution were divided into traditional and electronic, internal and external. Among the main information resources that form the information flows of the institution are the organizational and administrative documentation of the institution, the information automated system «Driving School» workstation, the institution’s website, page and groups on social networks, external electronic information resources of government bodies on legislative and regulatory information, website of the information automated system’s developer regarding technical support of the «Driving School» workstation. The construction of a figurative-symbolic information model in the form of a scheme containing a combination of graphic and textual elements was carried out. </em></p><p><strong><em>Novelty.</em></strong><em> Building an information model of information resources of the institution for the drivers training helped to identify features and some gaps in the information support of the institution, the appropriate level of which serves to ensure transparency and openness of its activities in accordance with current laws, regulations and technologies.</em></p><p><strong><em>Practical significance.</em></strong><em> The main types of information resources that have a decisive influence on the activities of the institution for the vehicle drivers training were identified. Analysis of the state of use of these information resources can be used in the process of conducting a regular information audit of the institution. </em></p><strong><em>Key words:</em></strong><em> information model, information resource, information modeling, automated information system, electronic document management. </em>
PRAGMATIC VALUE OF SERVICE-EXPERT PROGRAMS IN UKRAINIAN TELEVISION SPACE
Authors: Tregub A. 
Published: March 2022

<p class="1"><em>The purpose </em><em>of the study is to empirically determine the list of pragmatic values of service-expert programs of own production and production by special order of top rated national TV channels of Ukraine.</em></p><p><strong><em>Research methodology.</em></strong><em> The research uses methods of analysis, synthesis, abstraction and generalization, as well as a survey conducted by correspondence mass questionnaire in electronic (written) form using Google Tools.</em></p><p><strong><em>Results.</em></strong><em> </em><em>As a result of the survey, a list of pragmatic values for each of the thematic categories of service-expert programs of own production and production by special order of rating TV channels of Ukraine of national broadcasting was developed, empirically confirmed and supplemented by questioning TV viewers, namely for such: «travel», «living arrangement», «psychology of relations», «medicine and health», «cooking», «life», «beauty», «fashion and style», «service sphere».</em></p><p><em>According to the respondents' answers to additional questions of the questionnaire, five thematic categories of service-expert programs were identified, based on timeless values: «travel», «cooking», «psychology of relationships», «medicine and health», «sphere». maintenance «, which are a priority for viewing archival issues, as well as retransmission of useful information for more than half of the surveyed viewers.</em></p><p><strong><em>Novelty.</em></strong><em> For the first time, the pragmatic value of service-expert programs for TV viewers was empirically determined.</em></p><p><strong><em>Practical significance.</em></strong><em> The results of the study can be used in the practice of television production of service-expert programs, in particular, taken into account in the development of concepts and plots of programs.</em></p><strong><em>Key words: </em></strong><em>service-expert programs, Ukrainian television, pragmatic value, thematic categories, survey, television viewer.</em>
АВТОРСЬКА КОЛОНКА В ЖАНРОВІЙ ПАРАДИГМІ СУЧАСНИХ ЗМІ
Authors: Zaitseva I. 
Published: March 2022

<p><strong><em>The purpose </em></strong><em>of the study<strong> </strong>is to analyze the impact of the author's column on the image of a modern newspaper.</em></p><p><strong><em>Research methodology</em></strong><em>. The basis of the study is informational, axiological, culturological, systemic, active approaches; the following methods were used: analysis, synthesis, generalization – to clarify the author’s intension, which appears in media text and correlates with the standards of journalism.</em><em></em></p><p><strong><em>Results. </em></strong><em>The article<strong> </strong></em><em>outlines the features of the materials of the author’s column in the genre paradigm of modern media. The theoretical basis for the formation and figuring of a column in a genre paradigm with the practical implementation of this text form in the media space is investigated. It is emphasized that today the author's column is one of the most popular text forms on the media pages, which fully reflects the processes taking place in the modern information space, </em><em>і</em><em>t absorbs elements of different genres, trying to find its niche. It is clear that the specifics of the column are in the author's reflection on which the story is kept. The author, who leads the column, can choose a convenient form of self-expression, and quite often this form is dictated by the process of genre diffusion. A column as a genre has its own characteristics: the subject of the column, function, method, content and form.</em><em></em></p><p><strong><em>Novelty.</em></strong><em> The author’s intension of Vitaliy Zhezhera («Gazeta.ua» information portal) was formulated when writing a column, as well as the means of expressiveness of the artistic text he created was characterizd.</em><em></em></p><p><strong><em>Practical significance. </em></strong><em>The results of the study can be used in practical media activities and in the process of studying professionally oriented courses of the «Journalism» specialty.</em><em></em></p><p><strong><em>Key</em></strong><strong><em> </em></strong><strong><em>words:</em></strong><em> author's column, information genres, domestic column science, media text.</em><em></em></p>
УКРАЇНСЬКО-КАНАДСЬКИЙ ЧАСОПИС «НОВИЙ ШЛЯХ»: ПЕРІОД СТАНОВЛЕННЯ ТА РОЗБУДОВИ (1930–1941)
Authors: Bohuslavskyi O. В 
Published: March 2022

<p><strong><em>The purpose of the study</em></strong><em> is to determine the peculiarities of the formation and development of the Ukrainian periodical in emigration, which provides for the systematization and introduction into scientific circulation of factual material on the activities both of the </em><em>«</em><em>Novyi Shliakh</em><em>»</em><em> editorial staff and socio-political environment that influenced the information and ideological policy of the publication.</em></p><p><strong><em>Research methodology.</em></strong><em> The basis of the study is axiological, culturological, and systemic approaches; methods of historicism, analysis, synthesis, and generalization are used.</em></p><p><strong><em>Results.</em></strong><em> The period of formation and development of the editorial staff of the «</em><em>Novyi Shliakh</em><em>» weekly of 1930-1941 is outlined. The financial, economic, socio-political and social conditions of the beginning of the periodical’s functioning are clarified. The reasons for the low audience activity of Ukrainian settlers in Canada are identified. It is emphasized that the main merit in the process of formation of the weekly lies in the volunteer, unpaid work of the editorial team, which provided the basis for financial stability in the future. The mechanisms of expanding the readership network, attracting new authors are analyzed.</em></p><p><em>It was found out that it was the efforts of the editor M. Pohoretskyi, the head of the printing house I. Solianych and the directors of the publishing house V. Hultai, I. Huliai and O. Hryhorovych that created and strengthened the material and technical base of the publishing house, conducted advertising campaigns, carried out direct work to attract new subscribers and readers.</em></p><p><strong><em>Novelty.</em></strong><em> For the first time, information on the period of formation and development of the Ukrainian-Canadian </em><em>«</em><em>Novyi Shliakh</em><em>» </em><em>weekly was analyzed and summarized.</em></p><p><strong><em>Practical significance.</em></strong><em> The results of the research can be used in the process of studying the courses </em><em>«</em><em>History of Ukrainian Journalism</em><em>»</em><em> and </em><em>«</em><em>History of Publishing Business</em><em>»</em><em> within the </em><em>«</em><em>Journalism</em><em>» </em><em>specialty.</em></p><p><strong><em>Keywords: </em></strong><em>«</em><em>Novyi Shliakh</em><em>»</em><em>, emigration, Ukrainian National Union, nationalism, editor, publisher, page, column, audience, subscription.</em></p>
Consumer Attributes in Buying Processed Fish in Kuala Bubon Village
Authors: Sawita Rahma , Yoga Nugroho  
Published: March 2022

Kuala Bubon Village is one of the villages in the Samatiga sub-district where many of the residents work as fishermen and fish processors. In 2018 the number of industries and production of fish processing in Kuala Bubon Village there are 10 industries with a production output of 110,870 Kg.In addition to the salted fish processing area, there is also a processed fish stall. Consumers are the key in the buying and selling process. Processed fish traders in Kuala Bubon village do not yet know the importance of identifying what is the basis for consumers to buy processed fish, for that it is necessary to do research on consumer attributes so that they can know what to do for business sustainability. Collecting data using incidental sampling technique by way of interviews distributing questionnaires directly and through online. The method used in this study is a Likert scale with percentage analysis. From the research results obtained several attributes that become the basis of consumers in buying processed fish, namely service with a percentage value of 98.6%,then followed by convenience of place 94.2%, price 93.6%, hygienic place of sale 91.4%, distance and location of kiosks89.8%, the taste of processed fish 89.6%, the variety of types of fish sold 87.2%, recommendations from friends and neighbors 75.4%, and processed fish packaging 74.2%. with the results of this study, it is hope that it can become a reference for processed fish traders in managing their sales strategies and can improve business sustainability in terms of better production and marketing of processed fish. In addition, it is also hoped that it can be developed into research leads to strategies in making sustainable businesses in the fisheries sector.
Saúde da gestante no contexto de emergência em saúde pública: reflexos da pandemia da COVID-19
Authors: Parenti Ana Beatriz Henrique , Cruz Cristina Santana , Berzuini Grazielle Aparecida , Bernardo Luana Silva , Silva Tatiane Gisele Marques da , Clapis Maria José , Silva Monica Maria de Jesus , Panobianco Marislei Sanches 
Published: March 2022

Trata-se de um estudo de reflexão teórica que objetivou apresentar as repercussões do Coronavírus na saúde da gestante e discorrer sobre as repercussões da pandemia da COVID-19 no cuidado em saúde à essa população, fundamentado nas recomendações propostas pela Organização Mundial da Saúde. Para tanto, apresenta uma reflexão sistematizada e discussão em torno de dois eixos principais: 1) Gestantes e a COVID-19” e 2) Atenção à saúde da gestante na pandemia. Compreender a essencialidade do planejamento e a organização dos serviços de saúde nos diversos níveis de atenção em saúde é de suma importância para o enfrentamento da pandemia e para a promoção do cuidado integral à gestante, principalmente em contextos de emergência sanitária.
Efeitos farmacológicos da associação entre anti-hipertensivos e anti-inflamatórios não-esteroides: uma revisão atualizada
Authors: Almeida Andrey Sady de Sousa , Falcão Júnior Fabiano Veloso , Cunha Daniele Cavalcante Medeiros da , Araujo Nathalia Gaioso Marinho , Veras Leiz Maria Costa 
Published: March 2022

A Hipertensão Arterial Sistêmica (HAS) é considerada uma doença degenerativa multifatorial crônica e uma síndrome poligênica. Normalmente, a farmacoterapia anti-hipertensiva começa com medicamentos anti-hipertensivos de primeira linha em monoterapia ou em combinação, que pode ser preferível em pacientes idosos com níveis mais elevados de pressão arterial (PA). O envelhecimento também é acompanhado de considerável aumento do uso de outros medicamentos, destacando-se o uso de drogas analgésicas e anti-inflamatórias, tais como anti-inflamatórios não-esteroides (AINEs). Portanto, o objetivo desta revisão é demonstrar as possíveis interações entre anti-hipertensivos e AINEs, bem como destacar as principais reações adversas ocasionadas por tais interações, de acordo com dados publicados nos últimos cinco anos. Foi realizada uma revisão da literatura científica, nacional e internacional, que contivessem em seus títulos e/ou resumos os seguintes descritores: hipertensão arterial sistêmica, anti-hipertensivos, anti-inflamatórios, AINEs. O uso de poliquimioterapia traz uma preocupação constante sobre a interação medicamentosa e os efeitos adversos que decorrem dela. Os estudos analisados reportam o uso de anti-hipertensivos (principalmente inibidores do sistema renina-angiotensina) associados a AINEs e suas consequências, como doenças cardiovasculares, nefrotoxicidade e hipercalemia. Acredita-se que a prescrição racional e adequada desses fármacos pode minimizar os efeitos adversos decorrentes da interação medicamentosa.
Functionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H2O2 in Cancer Cells
Authors: Huang Wei , Xu Yun , Sun Yimin 
Published: March 2022

The rational design and construction of high-performance flexible electrochemical sensors based on hierarchical nanostructure functionalized microelectrode systems are of vital importance for sensitive in situ and real-time detection of biomolecules released from living cells. Herein, we report a novel and facile strategy to synthesize a new kind of high-performance microelectrode functionalized by dual nanozyme composed of rime-like Cu2(OH)3NO3 wrapped ZnO nanorods assembly [Cu2(OH)3NO3@ZnO], and explore its practical application in electrochemical detection of hydrogen peroxide (H2O2) released from living cells. Benefiting from the merits of the unique hierarchical nanohybrid structure and high catalytic activities, the resultant Cu2(OH)3NO3@ZnO-modified AGF microelectrode shows remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 1 μM and a high sensitivity of 272 μA cm−2 mM−1, as well as good anti-interference capability, long-term stability, and reproducibility. These properties enabled the proposed microelectrode-based electrochemical platform to be applied for in situ amperometric tracking of H2O2 released from different types of human colon cells, thus demonstrating its great prospect as a sensitive cancer cell detection probe for the early diagnosis and management of various cancer diseases.
Experimental Study on Coal and Gas Outburst Risk in Strong Outburst Coal Under Different Moisture Content
Authors: Lu Zhuang , Wang Liang , Lv Mingzhe , Lei Yang , Wang Hao , Liu Qingquan 
Published: March 2022

Coal and gas outburst is an extremely serious dynamic phenomenon involving the comprehensive action of many factors, and remains a major disaster that needs to be solved in coal mine production. Considering the significant influence of moisture content on coal and gas outburst, it is necessary to carry out experimental research on coal and gas outburst under different moisture content conditions. The coal of the serious outburst coal seam in the Luling coal mine, which has had several coal and gas outburst accidents, was selected as the experimental sample. Firstly, the gas desorption law and outburst index characteristics of coal under different moisture content were studied, and the influence of moisture content on gas outburst parameters of coal was obtained. Then, the simulation tests of coal and gas outburst under different moisture content were carried out by using a triaxial coal and gas outburst simulation test system. Based on the above experimental research, the influence of moisture on coal and gas outburst was summarized, and the energy calculation and prevention countermeasures of coal and gas outburst under different moisture content conditions were carried out. With the increase of moisture content, the adsorption constant a, the initial velocity of gas diffusion Δp, and the gas desorption index of drill cuttings K1/Δh2 decrease, but the Protodyakonov coefficient f increases, all of which have an exponential relation to moisture content. Meanwhile, with the increase of moisture content, the threshold of coal and gas outburst pressure increases, and the intensity and energy of outburst decrease. At 0.45 MPa pressure, the outburst of 1.47% moisture content is the most serious, the outburst of 5% moisture content is weakened, while the outburst of 10% moisture content is not triggered. Five percent moisture content can be used as a critical index of hydraulic measures to prevent coal and gas outburst in No. 8 coal seam of the Luling coal mine. This research can provide new insights into the theoretical study of coal and gas outburst in serious outburst coal seams and the control of coal and gas outburst by hydraulic measures.
Calcium Carbonate Dissolution Triggered by High Productivity During the Last Glacial–Interglacial Interval in the Deep Western South Atlantic
Authors: Suárez-Ibarra Jaime Y. , Frozza Cristiane F. , Palhano Pâmela L. , Petró Sandro M. , Weinkauf Manuel F. G. , Pivel Maria A. G. 
Published: March 2022

Studies reconstructing surface paleoproductivity and benthic environmental conditions allow us to measure the effectiveness of the biological pump, an important mechanism in the global climate system. In order to assess surface productivity changes and their effect on the seafloor, we studied the sediment core SAT-048A, spanning 43–5 ka, recovered from the continental slope (1,542 m water depth) of the southernmost Brazilian continental margin, deep western South Atlantic. We assessed the sea surface productivity, the organic matter flux to the seafloor, and calcite dissolution effects, based on micropaleontological (benthic and planktonic foraminifers, ostracods), geochemical (benthic δ13C isotopes), and sedimentological data (carbonate and bulk sand content). Superimposed on the induced changes related to the last glacial–interglacial transition, the reconstruction indicates a significant and positive correlation between the paleoproductivity proxies and the summer insolation. From the reconstructed data, it was possible to identify high (low) surface productivity, high (low) organic matter flux to the seafloor, and high (low) dissolution rates of planktonic Foraminifera tests during the glacial (postglacial). Furthermore, within the glacial, enhanced productivity was associated with higher insolation values, explained by increased northeasterly summer winds that promoted meandering and upwelling of the nutrient-rich South Atlantic Central Water. Statistical analyses support the idea that productivity is the main cause for seafloor calcium carbonate dissolution, as opposed to changes in the Atlantic Meridional Overturning Circulation (at least for the 25–4 ka period). Further efforts must be invested in the comprehension and quantification of the total organic matter and biogenic carbonate burial during time intervals with an enhanced biological pump, aiming to better understand their individual roles.