bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tocilizumab fails survival benefit in severe COVID-19 – A retrospective cohort study
Authors: Arjun  , Ranka Rajat , Panda Prasan Kumar 
Published: May 2022

Objectives:
Anti-interleukin-6 monoclonal antibody, tocilizumab, has produced mixed results in clinical trials for effectiveness against coronavirus disease 2019 (COVID-19). We conducted a retrospective cohort study to compare outcomes at 28 days of a cohort of patients with severe COVID-19 treated with tocilizumab and standard care, with those receiving standard care only.

Materials and Methods:
In this record-based retrospective cohort study, patients hospitalised with COVID-19 were classified into non-severe and severe disease as per institutional protocol. One cohort received tocilizumab with standard care and the second cohort received only standard care. Few patients also received high-dose steroids as ‘pulse’ steroids on initial clinical deterioration. Data were collected for the treatment given including oxygen interface, steroids, antimicrobials, duration of hospital stay in survivors, requirement of mechanical ventilation, and day of intubation from symptom onset. The primary outcome was to compare the all-cause mortality between the two groups. The effect of pulse steroid therapy on all-cause mortality was studied in the secondary outcome.

Results:
There was statistically significant mortality in the tocilizumab cohort as compared to standard care alone (HR 2.43, 95% CI 1.54–3.89). The need for mechanical ventilation was more in the tocilizumab cohort (85% vs. 18%, P < 0.001). Tocilizumab cohort had a delay in the day of intubation by a mean of 2.29 days from the day of symptom onset (P < 0.05). Pulse steroid administration showed increased all-cause mortality (HR 1.94, 95% CI 1.18–3.20) and risk of mechanical ventilation.

Conclusion:
Tocilizumab cohort showed higher mortality and need for mechanical ventilation in our study which contrasts the result of a few previous trials. Our study warrants the need for future clinical trials on this subject to ensure better treatment strategies in upcoming COVID-19 waves.
Role of an enriched environment in ameliorating early life stress-induced changes in structure and functions of hippocampus and amygdala in rats
Authors: Khokhar Sunil Kumar , Kambali Maltesh , Mussavira Sayeeda , Bindhu O. S. , Laxmi T. R. 
Published: May 2022

Objectives:
This study aimed to understand whether an enriched environment (EE) in adulthood benefits in mitigating the early life stress-induced changes in the structure and functions of the hippocampus and amygdala.

Materials and Methods:
Male Wistar rats were exposed daily for 6 h to early maternal separation and isolation (MS) stress from postnatal days (PND) 4–14 and later at PND 60–70 days subjected to EE, while, the normal control (NC) rats were not subjected to stress but reared with the mother under standard housing conditions. The effects of MS and EE on adulthood behaviour were not subjected to stress but assessed by measuring the ambulatory, repetitive and anxiety-like behaviour. The study has also done the plasma corticosterone concentrations. The dendritic remodelling in the amygdala and hippocampus was assessed using the Golgi cox staining approach. Finally, the present study compared the reactive oxygen species-induced lipid peroxidation and total antioxidant capacity in MS rats as an indirect measure of oxidative stress to study the impact of MS stress on the limbic circuit and peripheral organs.

Results:
MS rats showed increased anxiety and lower plasma corticosterone levels. The pyramidal neurons’ dendritic plasticity displayed a different pattern, with shrinkage in the CA1 hippocampal neurons and hypertrophy in the amygdala’s primary neurons. Variations in antioxidant activity and peroxidation observed in NC to MS across tissues indicate the occurrence and management of oxidative stress in MS. The 10 days of EE in young adulthood helped to reduce MS stress-induced structural abnormalities in hippocampal and amygdala pyramidal neurons, as well as anxiety and plasma corticosterone levels.

Conclusion:
These findings together indicate that exposure to adverse experiences may cause harmful effects on brain plasticity and behaviour in young adulthood. Exposure to EE may be beneficial in reducing the early life stress-induced pathophysiology later in life.
The Shared Landscape. Strategies for Ethical and Democratic Living
Authors: Brugiatelli Vereno 
Published: May 2022

Abstract
Living is placed within an environmental fabric consisting of infinite abiotic, biotic and cultural threads. Integrated living is required to be part of this fabric. Ethical living, characterised by knowledge, awareness and responsibility towards the landscape is the only way to protect the environment and enhance its biological and cultural wealth to effectively contribute to the fundamental quality of living and man’s well-being. Ethical living needs active participation shared by the inhabitants in the processes of protection, transformation and management of the landscape. In turn, such participation requires fostering by the ethics of living. In this study, from a phenomenological and hermeneutic viewpoint, I intend to highlight some fundamental structures of living to demonstrate that democratic participation is a determining factor in contributing to the realisation of integrated living, which is indispensable for respect of the landscape to promote quality of life and man’s well-being.
Policy Implications for the Green Bank Development in the Context of Global Climate Change
Authors: Thi Hang Nga Phan 
Published: May 2022

With the global financial crisis in 2008, climate change, and the COVID-19 pandemic, most countries worldwide have re-thought their organization and operating models in their financial systems, including the banking system. In Vietnam, sustainable economic development has become an essential need in the long term. However, sustainable development requires a balance between economic growth and environmental protection. Therefore, Vietnam has chosen to develop a green economy, in which "green banks" have an essential role. Green banking is a future banking model that balances all stakeholders' economic and environmental benefits and costs in banking activities. Green banking emerges as an ideal model for future banking, a foundation for a green economy and sustainable development. Therefore, the article analyzes the current situation and some challenges to promoting the development of green banking in Vietnam and proposes policy recommendations to promote green banking development in Vietnam in the coming time. The article used methods to test the reliability of Cronbach's alpha scale, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and SEM to test the research hypotheses based on surveying 700 commercial bank managers and collecting data by a convenient sampling method from June 2021 to December 2021. Research novelty explores five factors affecting green bank development with a significance level of 1.0%. Finally, the author had policy implications for developing the green bank in the future. Doi: 10.28991/ESJ-2022-06-04-011 Full Text: PDF
СУЧАСНІ ТЕНДЕНЦІЇ В АМЕРИКАНСЬКІЙ ПСИХОЛОГІЇ СПОРТУ І ФІЗИЧНИХ ВПРАВ
Authors: Шевчук Ольга , Власюк Дмитро 
Published: May 2022

Мета. У статті здійснено теоретичний аналіз організаційних і концептуальних змін які спостерігаються в сучасній психології спорту та фізичних вправ в США.
Методи. Для реалізації мети дослідження нами використовувався аналіз публікацій в профільних наукових журналах, а також вивчення офіційних документів та інформаційних матеріалів професійних об’єднань спортивних психологів.
Результати. Розвиток психології спорту в США демонструє більш швидкий поступальний рух починаючи з 90-х років. Спостерігається якісне зростання в галузі практик прикладної психології спорту. Відмічається затребуваність напрацювань психологів – практиків в сфері психології продуктивності. Проте в процесі розвитку виявились організаційні і методологічні проблеми розширення сфери прикладного застосування набутого досвіду, інтеграції з організаційними культурами спортивних організацій, професійної ідентифікації, навчання і сертифікації компетентностей. Провідні фахівці психології спорту рекомендують здійснювати більш послідовні кроки в напрямі визначення дисципліни, як підгалузі психології продуктивності, визначитись з місцем і функціями спортивних психологів в організаційній культурі спортивних організацій, формувати професійну ідентичність спортивних психологів, проводити розмежування на рівні професійних послуг і компетентностей з психологією фізичних вправ, продовжувати діяльність по вдосконаленню професійних етичних і кваліфікаційних стандартів відповідно до вимог часу.
Висновки Проведене дослідження показало, що увагу експертів в найбільшій мірі привертають проблеми трансформації поля діяльності спортивних психологів, вивчення і поширення передових практик, місця спортивних психологів в організаційній культурі спортивних організацій, професійної ідентифікації спортивних психологів, навчальних програм по актуальними професійними компетентностями, вдосконалення нормативної бази сертифікації фахівців.
PEMURNIAN BIOGAS MENGGUNAKAN ABSORBER PACKED COLUMN DALAM MENYERAP IMPURITIES CO2 DAN H2S DENGAN SIMULASI ASPEN HYSYS V.10
Authors: Nasution Amanda Fitria Rahmadani , Nasrul ZA Mr , Novi Sylvia Mrs. , Ishak Mr. , Lukman Hakim Mr. 
Published: May 2022

Palm Oil Mill Effluent (POME) merupakan salah satu limbah minyak kelapa sawit yang harus diolah karena dapat berakibat buruk terhadap lingkungan. POME memiliki kandungan gas rumah kaca yang cukup tinggi, yang berkontribusi terhadap pemanasan global. Saat ini, salah satu jalur pengelolaan POME adalah dengan mengolah POME menjadi biogas. Penelitian ini bertujuan untuk menghilangkan kandungan impurities biogas yaitu gas karbon dioksida (CO2) dan hidrogen sulfida (H2S) sehingga dapat menghasilkan gas metana (CH4) dengan kemunian yang tinggi. Penelitian ini dilakukan dengan mensimulasikan pemurniaan biogas menggunakan absorber packed column pada Aspen Hysys V.10 dengan menvariasikan debit air yg masuk pada absorber packed column serta komposisi awal pada biogas. Berdasarkan hasil penelitian diperoleh bahwa pemurnian biogas menggunakan air pada absorber packed column dapat meningkatkan kemurnian gas metana (CH4) pada biogas yang diikuti dengan meningkatkan debit air yang digunakan. Namun air yang digunakan sebagai pemurnian biogas juga dapat mengurangi kandungan gas karbon dioksida (CO2) dan gas hidrogen sulfida (H2S) dalam biogas karena kedua gas tersebut memiliki nilai kelarutan yang lebih tinggi dibandingkan dengan gas metana (CH4). Dimana kelarutan karbondioksida (CO2) dalam air 1,45 g/L dan kelarutan hidrogen sulfida (H2S) dalam air 4 g/L lebih tinggi ketimbang kelarutan metana (CH4) dalam air yaitu 0,035 g/L. Nilai HHV (High Heating Value) biogas meningkat dengan meningkatnya kemurnian dari gas metana pada biogas karena di dalam biogas, gas yang terkandung paling banyak adalah gas metana. Bertambahnya komposisi dari gas metana pada biogas diikuti dengan meningkatnya debit air yang digunakan pada absorber packed column. Sehingga, nilai HHV (High Heating Value) biogas dapat meningkat yang diikuti dengan meningkatnya kemurnian dari gas metana pada biogas.
THE SILTING UP OF VEGETABLE CROP AREA IN GANDIOLAIS (NORTHERN COAST OF SENEGAL)
Authors: F Diome , A. K. Tine , L Biaye 
Published: May 2022

The Gandiolais is part of the large "Niayes" ecosystem in the Saint Louis region. It is bordered by active dunes from the recent Quaternary delimiting interdune depressions in which the sub-surface water table has favored the practice of vegetable crops. These vegetable cropping areas are production systems that are now facing silting up.
Our results show that this silting is due to deflation and/or mass movement of dune soils. These two phenomena are generated by the sensitivity of dune soils to deflation by trade winds and drought. The resulting negative consequences include, among others, the abandonment of vegetable cropping activities by farmers.
Solutions to reduce trade wind speeds and improve the cohesion and structuring of dune soils are proposed. In particular, we recommend the creation of windbreaks and the reconstitution of sufficient plant cover.
PENGARUH KEPEMIMPINAN TRANFORMASIONAL DAN MOTIVASI KERJA TERHADAP KINERJA GURU
Authors: Asdi Ahmad 
Published: May 2022

<span>Tujuan penelitian ini adalah untuk menguji pengaruh kepemimpinan transformasional dan motivasi kerja guru terhadap kinerja guru. Jenis penelitian ini menggunakan metode deskriptif dengan pendekatan kuantitatif. Penelitian ini juga menggunakan metode regresi yang bertujuan untuk menguji pengaruh/nilai pengaruh dua variabel bebas terhadap satu variabel terikat. Populasi penelitian adalah seluruh Guru di Madrasah Aliyah Negeri Dua Pesisir Selatan. Sampel sebanyak 79 orang responden guru. Kepemimpinan dan Motivasi kerja secara bersama-sama berpengaruh terhadap kinerja Guru di MAN 2 Pesisir Selatan, hal ini menjelaskan bahwa Kepemimpinan dan iklim kerja memberikan pengaruh terhadap kinerja Guru, artinya semakin tinggi Kepemimpinan dan semakin baik Motivasi kerja maka akan semakin meningkat kinerja Guru. Hasil penelitian ini perlu disosialisasikan kepada kepala sekolah agar kepala sekolah menanamkan konsep Kepemimpinan kepada Guru serta menciptakan iklim kerja yang sehat, hangat dan positif. </span>
ANALISIS KEMAMPUAN STRATEGIC COMPETENCE SISWA DALAM KECAKAPAN MATEMATIS PADA MATERI PROGRAM LINEAR DITINJAU DARI GAYA KOGNITIF
Authors: Aisyah Nur , Ma’rufi Ma’rufi , Salwah Salwah 
Published: May 2022

Penelitian ini merupakan penelitian deskriftif dengan pendekatan kualitatif yang ditujukan untuk menganalisis kemampuan strategic competence siswa kelas XII IPA 3 SMA Negeri 1 Luwu Utara pada materi program linear ditinjau dari gaya kognitif siswa. Subjek dalam penelitian ini adalah siswa kelas XII IPA 3 SMA Negeri 1 Luwu Utara yang berjumlah 2 orang berdasarkan gaya kognitif, yaitu subjek field dependent (SFD) dan subjek field independent (SFI). Pengumpulan data dilakukan dengan pemberian test GEFT terlebih dahulu untuk memilih siswa dengan gaya kognitif field dependent dan field independent, selanjutnya kedua subjek yang telah terpilih diberikan tes kecakapan matematis yang dilanjutkan dengan sesi wawancara secara individu guna memperoleh data yang valid. Hasil penelitian menunjukkan kemampuan strategic competence siswa berdasarkan gaya kognitif dalam menyelesaikan materi program linear telah memenuhi keempat indikator dari strategic competence yaitu: (a) Memahami situasi serta kondisi dari suatu permasalahan, (b) Menyajikan masalah secara matematik dalam berbagai bentuk, (c) Menemukan hubungan matematika yang ada didalam suatu masalah dan (d) Menemukan solusi dari permasalahan yang diberikan, untuk subjek field dependent (SFD) sedangkan untuk subjek field independent (SFI) memenuhi indikator yaitu: Memahami situasi serta kondisi dari suatu permasalahan, menemukan hubungan matematika yang ada didalam suatu masalah dan menemukan solusi dari permasalahan yang diberikan.
Studi Pandangan Hakim Pengadilan Tinggi Agama Medan Terhadap Fatwa MUI Sumut Tentang Istbat Talak di Luar Sidang Pengadilan Agama
Authors: Rahim Nasrullah Abdul , Adly Muhammad Amar , Syahputra Akmaluddin 
Published: May 2022

Majelis Ulama Indonesia (MUI) Provinsi Sumatera Utara mengeluarkan Fatwa Nomor : 04/KF/MUI-SU/IV/2011 Tentang : Isbat Talak Terhadap Perceraian/Talak Di Luar Sidang Pengadilan Agama yang diputuskan pada tanggal 12 April 2011M/08 Jumadil Awal 1432H sebagai usulan kepada Mahkamah Agung untuk mengeluarkan aturan terhadap isbat terhadap perceraian yang dilakukan di luar pengadilan agar pasangan yang telah bercerai di luar pengadilan mendapatkan legalitas terhadap status yang disandangnya. Padahal dalam Kompilasi Hukum Islam (KHI) Pasal 115 sudah jelas dinyatakan bahwa “Perceraian hanya dapat dilakukan di depan sidang Pengadilan Agama setelah Pengadilan Agama tersebut berusaha dan tidak berhasil mendamaikan kedua belah pihak”. Oleh karena itu, penelitian bertujuan untuk menjawab bagaimana kedudukan talak di luar pengadilan, bagaimana kedudukan fatwa Majelis Ulama Indonesia (MUI) dalam hukum positif di Indonesia, bagaimana pandangan para Hakim Pengadilan Tinggi Agama Medan terhadap fatwa Majelis Ulama Indonesia (MUI) Provinsi Sumatera Utara Nomor : 04/KF/MUI-SU/IV/2011 Tentang : Isbat Talak Terhadap Perceraian/Talak Di Luar Sidang Pengadilan Agama dan bagaimana penerapannya. Penelitian ini adalah penelitian hukum empiris dengan pendekatan kualitatif, teknik pengumpulan data pada penelitian ini yaitu observasi, wawancara, dan studi dokumen, dan metode analisis data dalam penelitian ini menggunakan metode analysis deskriftif. Penelitian ini menemukan bahwa: 1. Perceraian yang dilakukan di luar persidangan tidak dianggap ada dan tidak sah menurut Undang-Undang yang berlaku di Indonesia. Tapi kalau ucapan cerai itu dilakukan di depan hakim atau di depan pengadilan, satu kali diucapkan maka perceraian itu diakui sah dan legal dengan bukti dikeluarkannya surat ikrar talak dari pengadilan (akta cerai). 2. Maka kedudukan Fatwa Majelis Ulama Indonesia (MUI) bukan merupakan suatu jenis peraturan perundang-undangan yang mempunyai kekuatan hukum mengikat.
Inovasi Pengembangan Kurikulum dengan Pendekatan Saintifik Untuk RA/PAUD di Provinsi Banten
Authors: Afif Nur , Ayuningrum Desy , Imran Ali , Qowim Agus Nur 
Published: May 2022

Inovasi pengembangan kurikulum yang dilakukan untuk anak usia dini sangat penting untuk meningkatkan kemampuan anak. Pendekatan saintifik dapat menstimulasi pemikiran anak dalam kegiatan sains. Tujuan penelitian ini antara lain untuk mengkaji proses inovasi kurikulum dan implementasi pendekatan saintifik dalam inovasi kurikulum untuk RA/PAUD di Banten. Metode penelitian adalah metode kualitatif. Penelitian dilakukan pada RA/PAUD di Banten. Hasil penelitian menjelaskan pengembangan inovasi kurikulum sesuai dengan kebutuhan masyarakat dan isi kurikulum sebagai solusi peningkatan anak usia dini,. Implementasi pendekatan saintifik pada siswa RA/PAUD diterapkan dengan metode melalui mengamati, menanya, mengumpulkan informasi, menalar, dan mengkomunikasikan pembelajaran pada anak usia dini.
Recortes da história para o ensino de juros
Authors: Medeiros Andréa Regina Henriques de , Chaquiam Miguel 
Published: May 2022

A partir da história da Matemática é possível elaborar atividades que podem ser utilizadas como recurso didático no ensino de conteúdos matemáticos por contemplar, entre suas potencialidades, a possibilidade de agregar significado, provocar a motivação e a curiosidade discente. Tendo em vista que poucos trabalhos retratam a história dos juros e, menos ainda a utilização de sua história no ensino, levantou-se o seguinte questionamento para balizar a pesquisa vinculada ao curso de mestrado profissional em Ensino de Matemática da Universidade do Estado do Pará (UEPA): Que recortes históricos podem ser efetuados a partir de uma história dos juros que contribuam para elaboração de atividade para uso em sala de aula. Foi estabelecido como objetivo para esse trabalho apresentar um recorte histórico das pesquisas relacionadas ao citado mestrado, tendo como objeto matemático juros. Para tanto, enveredou-se por pesquisa bibliográfica com abordagem qualitativa e, após revisão da literatura, para levantamento e organização temporal dos fatos históricos relacionados aos juros optou-se pelo diagrama-metodológico proposto por Chaquiam (2017, 2020), foi elaborado um texto visando a sua utilização durante o ensino de juros no ensino na educação básica. A apresentação desse material em sala de aula poderá agregar valor histórico na constituição desse objeto durante o processo de ensino, cuja existência milenar antecede a própria existência do dinheiro, dos bancos e da Matemática Financeira, e ao aluno que recorrentemente assiste esse conteúdo como um pacote acabado geralmente por meio de um algoritmo e listas de exercícios sem dar ênfase ao significado historicamente construído e consequentemente seu uso em sua vida. Ressalta-se que a pesquisa está em andamento, portanto, a validação do texto e das atividades ocorrerão após as análises dos dados obtidos nas empirias.
Ansiedade cognitiva de provas em universitários do Brasil: O papel das variáveis sociodemográficas e traços de personalidade
Authors: Nascimento da Silva Paulo Gregório Nascimento , Silva e Araújo Ramnsés , De Araújo Gleyde Raiane , Alves Mateus Egilson da Silva , De Medeiros Paloma Cavalcante Bezerra , Nunes da Fonseca Patrícia , Diógenes de Medeiros Emerson 
Published: May 2022

Objetivo: A presente pesquisa objetivou verificar o poder preditivo dos traços de personalidade, controlando o efeito das variáveis sociodemográficas (gênero e período que está cursando), na explicação da ansiedade cognitiva em avaliações. Métodos: Duzentos estudantes universitários de instituições públicas da cidade de Parnaíba, Piauí, (Midade = 23,97), em maioria mulheres (75%) e cursando Psicologia (52,5%) foram avaliados através da Escala de Ansiedade Cognitiva em provas, o Inventário dos Cinco Grandes Fatores da Personalidade e questões sociodemográficas. Resultados: As análises de correlação de Pearson e de regressão linear múltipla hierárquica mostraram que os traços de personalidade conscienciosidade (β = -0,15; p < 0,01), neuroticismo (β = 0,35; p < 0,01) e o gênero do participante (β = -0,19; p < 0,05) contribuem de maneira significativa para a explicação da ansiedade cognitiva de provas acadêmicas, com o modelo explicando cerca de 20% da sua variância. Os resultados sugeriram ainda que a conscienciosidade pode funcionar como um fator de proteção e o neuroticismo um agente de vulnerabilidade de sintomas ansiosos em contextos avaliativos, principalmente em mulheres, não havendo diferença quanto ao período cursado. Conclusões: Os achados enfatizam a importância de serem realizadas propostas psicoeducativas interventivas, particularmente em mulheres com acentuado nível de neuroticismo.
Controlled substitution of coarse aggregate with waste glass and syringe needle in M20 concrete
Authors: Adhikari Ranjana , Shrestha Yadin , Amatya Iswar Man , Motra Gokarna Bahadur 
Published: May 2022

Certain types of inorganic waste can be reused by substituting the primary materials of M20 concrete in controlled percentage. Inorganic wastes like waste glass and syringe needle are some of its examples which are currently being sent to landfill sites in a large share. This study considers the waste glass (toughen glass, flat glass) generated from the construction site & glass market and autoclaved syringe needle generated as a hospital waste. Waste glass was used to partially replace up to 20% and syringe needle 2% of coarse aggregate in combined form for all concrete mixes. The workability test, compressive strength test and Flexural strength test was conducted to evaluate the effectiveness of the mix. The use of combination of waste glass and syringe needle resulted in decreasing the slump value due to angular grain shape of glass and reinforcing property of needle, whereas the compressive strength noticeably enhanced. With increasing the waste glass and syringe needle percentage the strength gradually increases up to a given limit beyond which it started to decrease. The maximum compressive strength of concrete was obtained at 10% of waste glass and 1% of syringe needle and the value of the compressive strength of the for 28 days of curing is 32.29 N/mm2. The Flexural strength for the sample 2 was observed 3.07 N/mm2.