bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective solid‐phase microextraction of polycyclic aromatic hydrocarbons in water based on oriented phosphorus‐containing titanium oxide nanofibers grown on titanium support prior to high‐performance liquid chromatography with ultraviolet detection
Authors: Kang Jingyi , Chang Na , Wang Feifei , Liu Haixia , Wang Xuemei , Du Xinzhen 
Published: January 2022

AbstractA novel solid‐phase microextraction coating of phosphorous‐containing titanium oxide composite was developed using titanium fiber as a support and a titanium source by hydrothermal oxidation in a phosphoric acid solution containing hydrogen peroxide. The morphology of the fiber coatings was controlled by the conditions of the hydrothermal oxidation reaction. The oriented nanofiber coating was employed to extract several types of representative aromatic analytes. The experimental results demonstrated that the as‐prepared fiber exhibited excellent extraction efficiency toward polycyclic aromatic hydrocarbons. Combined with high‐performance liquid chromatography with ultraviolet detection, main extraction conditions were optimized, including pH, ionic strength, extraction temperature, stirring rate, extraction time and desorption time. The established method presented good linearity from 0.05 to 200 μg/L with limit of detection ranging from 0.012 to 0.126 μg/L. This convenient and green procedure was suitable for the selective extraction and determination of typical polycyclic aromatic hydrocarbons in environmental water samples. The relative recoveries of 85.8–112% were obtained for the determination of target polycyclic aromatic hydrocarbons in water samples spiked with 5.0 and 15.0 μg/L. Moreover, the as‐prepared fiber showed at least 210 extraction/desorption cycles due to its high mechanical and chemical stability.
Keeping the competition close: The impact of competitor distance in the lodging industry
Authors: Park Chansoo , Kim Young‐Rae , Frye William D. 
Published: January 2022

AbstractThis study applies a distance‐based measurement outlining market boundaries for competition in the lodging industry and investigates the effects of competition across a range of distances. Predetermined administrative boundaries have been the conventional metric used when estimating competition effects in a given geographical area in the lodging industry. For this study, distances are calculated using the location information of 45,623 hotels in the United States extracted from the Smith Travel Research Hotel Census. Our findings suggest a U‐shaped relationship: hotel room prices fall as relative distance increases, due to increasing negative price pressure, until a threshold distance is reached (a radius of 20 km), after which price pressure falls and prices begin to increase. These research findings have implications for hotel managers with respect to competitor management and for hotel investors interested in locating and developing future accommodation establishments.
Long non‐coding RNA Opa interacting protein 5‐antisense RNA 1 promotes mitochondrial autophagy and protects SH‐SY5Y cells from 1‐methyl‐4‐phenylpyridine‐induced damage by binding to microRNA‐137 and upregulating NIX
Authors: Zhao Ying , Xie Ying , Yao Wen‐Yan , Wang Yuan‐Yuan , Song Nina 
Published: January 2022

AbstractParkinson's disease (PD) is a leading cause of disability. Long noncoding RNA (LncRNA) OIP5‐AS1 alleviates the accumulation and toxicity of 1‐methyl‐4‐phenylpyridine (MPP+)/‐induced α‐synuclein in human neuroblastoma SH‐SY5Y cells, which may be involved in the pathological process of PD. This study explored the neuroprotective effect of lncRNA OIP5‐AS1 on MPP+/‐induced SH‐SY5Y cell model of PD, so as to provide a theoretical basis for PD treatment. The PD cell model was established (MPP+ group). The overexpression vector oe‐OIP5‐AS1 was constructed and transfected into MPP+/‐induced SH‐SY5Y cells, which were further transfected with miR‐137 mimic or si‐NIX plasmids. The localization of OIP5‐AS1 and its binding sites with miR‐137 were predicted by subcellular isolation and fluorescence in situ hybridization analysis. The targeting relationships between OIP5‐AS1 and miR‐137, and miR‐137 and NIX were detected by dual‐luciferase reporter assays. The mitochondrial membrane potential (Δψm) and total reactive oxygen species (ROS) levels, and expressions of α‐synuclein, inflammatory cytokines, and microglia‐activated chemokines, cell activity, and apoptosis were assessed. OIP5‐AS1 was downregulated in MPP+ cells. After OIP5‐AS1 overexpression, miR‐137 was downregulated and NIX was upregulated in MPP+ cells, inflammatory factors and chemokines were downregulated. There were target relationships between OIP5‐AS1 and miR‐137, and miR‐137 and NIX. After OIP5‐AS1 overexpression, miR‐137 overexpression or NIX downregulation inhibited mitochondrial autophagy and ROS levels and aggravated mitochondrial vacuolation; and partially reversed the effect of OIP5‐AS1 overexpression on promoting mitochondrial autophagy and protection on MPP+ cells. Collectively, lncRNA OIP5‐AS1 promoted NIX expression through competitively binding to miR‐137, and promoted mitochondrial autophagy, thus protecting neurons from degeneration which might be seen in patients with PD.
Photo‐Cross‐Linked Single‐Ion Conducting Polymer Electrolyte for Lithium‐Metal Batteries
Authors: Liang Hai‐Peng , Chen Zhen , Dong Xu , Zinkevich Tatiana , Indris Sylvio , Passerini Stefano , Bresser Dominic 
Published: January 2022

AbstractPolymer electrolytes are considered potential key enablers for lithium‐metal batteries due to their compatibility with the lithium‐metal negative electrode. Herein, cross‐linked self‐standing single‐ion conducting polymer electrolytes are obtained via a facile UV‐initiated radical polymerization using pentaerythritol tetraacrylate as the cross‐linker and lithium (3‐methacryloyloxypropylsulfonyl)‐(trifluoromethylsulfonyl)imide as the ionic functional group. Incorporating propylene carbonate as charge‐transport supporting additive allowed for achieving single‐ion conductivities of 0.21 mS cm−1 at 20 °C and 0.40 mS cm−1 at 40 °C, while maintaining a suitable electrochemical stability window for 4 V‐class positive electrodes (cathodes). As a result, this single‐ion polymer electrolyte featured good cycling stability and rate capability in Li||LiFePO4 and Li||LiNi0.6Mn0.2Co0.2O2 cells. These results render this polymer electrolyte as potential alternative to liquid electrolytes for high‐energy lithium‐metal batteries.
Trophic preferences of the pathogen Ralstonia solanacearum and consequences on its growth in xylem sap
Authors: Baroukh Caroline , Zemouri Meriem , Genin Stéphane 
Published: January 2022

AbstractRalstonia solanacearum is one of the most destructive pathogens worldwide. In the last 30 years, the molecular mechanisms at the origin of R. solanacearum pathogenicity have been studied in depth. However, the nutrition status of the pathogen once inside the plant has been poorly investigated. Yet, the pathogen needs substrates to sustain a fast‐enough growth, maintain its virulence and subvert the host immunity. This study aimed to explore in‐depth the xylem environment where the pathogen is abundant, and its trophic preferences. First, we determined the composition of tomato xylem sap, where fast multiplication of the pathogen occurs. Then, kinetic growth on single and mixtures of carbon sources in relation to this environment was performed to fully quantify growth. Finally, we calculated the concentration of available metabolites in the xylem sap flux to assess how much it can support bacterial growth in planta. Overall, the study underlines the adaptation of R. solanacearum to the xylem environment and the fact that the pathogen assimilates several substrates at the same time in media composed of several carbon sources. It also provides metrics on key physiological parameters governing the growth of this major pathogen, which will be instrumental in the future to better understand its metabolic behavior during infection.
A review of Plks: Thinking outside the (polo) box
Authors: Korns Julianna , Liu Xiaoqi , Takiar Vinita 
Published: January 2022

AbstractThe polo‐like kinase (Plk) family is comprised of five different members (Plk1–5), each with their own distinct functions. Plk family members participate in pivotal cell division processes as well as in non‐mitotic roles. Importantly, Plk expression has been correlated with various disease states, including cancer. Multiples therapies, which primarily target Plk1, are currently being investigated alone or in combination with other agents for clinical use in different cancers. As the role of Plks in disease progression becomes more prominent, it is important to outline their functions as cell cycle regulators and more. This review summarizes the structure and both mitotic and non‐mitotic functions of each of the five Plk family members, sequentially. Additionally, the proposed mechanisms for how Plks contribute to tumorigenesis and the therapeutics currently under investigation are outlined.
Encapsulation of Phase Change Materials via Interfacial Miniemulsion Polymerization for High Thermal Energy Storage Density
Authors: Zhao Yuhai , Luo Yingwu 
Published: January 2022

AbstractPhase change material (PCM) capsules have potential applications as a thermal management material in energy‐efficient buildings. It is desirable for PCM capsules to have high core‐loading and sub‐micrometer particle size. Herein, it is reported that interfacial reversible addition‐fragmentation chain transfer (RAFT) miniemulsion polymerization can be a convenient method to synthesize high PCM loading polymeric capsule latex. It is found that increasing particle size should be helpful to obtain well‐defined capsules of high PCM loading but post‐addition of surfactant should be carried out to remain the colloidal stability during polymerization. In the case of high PCM loading, a limiting conversion is observed. Increasing crosslinker (DVB) level up to 20 wt% based on monomers can increase the limiting conversion up to 94%. The well‐defined paraffin capsules of 365 nm in diameter is synthesized with 67 wt% PCM loading. The paraffin capsules have a crystallization/melting heat around 105 J g−1. Replacing paraffin with pure n‐octadecane, the crystallization/melting heat is increased up to 144 J g−1.
Recurrent FOXK1::GRHL and GPS2::GRHL fusions in trichogerminoma
Authors: Kervarrec Thibault , Pissaloux Daniel , Poilane Jeremie , Tirode Franck , Tallet Anne , Collin Christine , Tallegas Matthias , Berthon Patricia , Gaboriaud Pauline , Sohier Pierre , Calonje Eduardo , Luzar Boštjan , Goto Keisuke , Cokelaere Kristof , Lamant Laurence , Balme Brigitte , Wild Richard , Neuville Agnes , Deschamps Lydia , Auberger Elisabeth , Paumier Veronique , Bonte Helene , Moulonguet Isabelle , Plantier Françoise , Cales Valérie , Pinsolle Vincent , Roblet Denis , Dupuy Frantz , Dallot Alexiane , Seris Alice , Jouary Thomas , Houben Roland , Schrama David , Hesbacher Sonja , Macagno Nicolas , Battistella Maxime , Cribier Bernard , Vergier Beatrice , de la Fouchardière Arnaud , Jullie Marie‐Laure 
Published: January 2022

AbstractWe report 21 cases of trichogerminoma harbouring previously undescribed FOXK1::GRHL1/2 or GPS2::GRHL1/2/3 in‐frame fusion transcripts. Microscopic examination of a preliminary set of five cases revealed well‐delimitated tumours located in the dermis with frequent extension to the subcutaneous tissue. Tumours presented a massive and nodular architecture and consisted of a proliferation of basaloid cells. A biphasic pattern sometime resulting in tumour cell nests (‘cell balls’) was present. Immunohistochemistry demonstrated the expression of cytokeratins (CKs) 15, 17, and PHLDA1. In addition, numerous CK20‐positive Merkel cells were detected. RNA sequencing (RNA‐seq) revealed a FOXK1::GRHL1 chimeric transcript in three cases and a FOXK1::GRHL2 fusion in two cases. In a second series for validation (n = 88), FOXK1::GRHL1/2 fusion transcripts were detected by RT‐qPCR or FISH in an additional 12 trichogerminomas and not in any other follicular tumour entities or basal cell carcinoma cases (n = 66). Additional RNA‐seq analysis in trichogerminoma cases without detected FOXK1::GRHL1/2 rearrangements revealed GPS2::GRHL1 fusion transcripts in two cases, GPS2::GRHL2 in one case, and GPS2::GRHL3 fusion transcript in one case. Therefore, our study strongly suggests that GRHL1/2/3 gene rearrangements might represent the oncogenic driver in trichogerminoma, a subset of follicular tumours characterized by immature features and numerous Merkel cells. © 2022 The Pathological Society of Great Britain and Ireland.
Seed priming with selenium: Effects on germination, seedling growth, biochemical attributes, and grain yield in rice growing under flooding conditions
Authors: Hu Feng‐qin , Jiang Shuo‐chen , Wang Zhun , Hu Kang , Xie Yi‐mei , Zhou Ling , Zhu Jian‐qiang , Xing Dan‐ying , Du Bin 
Published: January 2022

AbstractPrevalent irregular rainfall, flooding for weed control, and unleveled fields in the middle and lower reaches of the Yangtze River all contribute to flooding stress on germination and growth of direct‐seeded rice (Oryza sativa L.). Herein, some experiments were conducted so as to assess the effects of seed priming with selenium (Se) on the germination and growth of rice under hypoxia. The experiment was arranged in a completely randomized factorial design with two factors and five replicates. Factors included Se concentration (0, 30, and 60 μmol/L) and duration of flooding stress (0, 2, 4, and 8 days). The experimental results showed that Se accelerated seed germination and increased emergence index and final emergence percentage. Additionally, Se increased shoot and root lengths and dry weights, but high Se concentration (60 μmol/L) reduced 18‐day‐old seedling dry weight under long‐term flooding (8 days). Furthermore, Se reduced malondialdehyde content and increased starch hydrolysis efficiency in seeds, superoxide dismutase, peroxidase, catalase, and glutathione peroxidase activities and seedling soluble protein and total chlorophyll contents. Se improved seedling total Se and organic Se contents while increasing total dry weight and yield. Notably, the highest yield was obtained after a 4‐day flooding period. Although Se priming favored rice seedling emergence and growth under flooding conditions, Se concentrations equal or above 60 μmol/L increased the risk of seedling death during long‐term flooding (≥8 days).
Ultra‐compact accurate wave functions for He‐like and Li‐like iso‐electronic sequences and variational calculus:II.Spin‐singlet (excited) and spin‐triplet (lowest) states of helium sequence
Authors: Turbiner Alexander V. , Lopez Vieyra Juan Carlos , del Valle Juan Carlos , Julian Nader Daniel 
Published: January 2022

AbstractAs a continuation of Part I (Int. J. Quantum Chem. 2021; 121: qua.26586), dedicated to the ground state of He‐like and Li‐like isoelectronic sequences for nuclear chargesZ ≤ 20, a few ultra‐compact wave functions in the form of generalized Hylleraas‐Kinoshita functions are constructed, which describe the domain of applicability of the Quantum Mechanics of Coulomb Charges (QMCC) for energies (4–5 significant digits [s.d.]) of two excited states of He‐like ions: the spin‐singlet (first) excited state 21Sand lowest spin‐triplet 13Sstate. For both states, it provides absolute accuracy for energy ∼10−3 a.u., exact values for cusp parameters and also for six expectation values the relative accuracy ∼10−2. Bressanini‐Reynolds observation about the special form of nodal surface of 21Sstate of helium is confirmed and extended to He‐like ions withZ > 2. Critical chargesZ = ZB, where ultra‐compact trial functions lose their square‐integrability, are estimated:ZB(11S) ≈ ZB(21S) ∼ 0.905 andZB(13S) ∼ 0.902. For both excited states, the Majorana formula—the energy as the second degree polynomial inZ—provides accurately the 4–5 significant digits forZ ≤ 20.
Agile flight for a quadrotor via robust geometry control: Theory and experimental verification
Authors: Gu Xun , Xian Bin , Wang Yinxin 
Published: January 2022

AbstractThis article investigates the agile flight control design for a quadrotor unnamed aerial vehicle in the 3D environment. Due to the need for the high speed flight and aggressive manoeuver in practical scenarios, the kinematic and dynamic models of the unmanned quadrotor are described in SO(3) and the controller is designed in the rotation format, which can avoid the singularity in the Euler angle format and the unwinding issue in the quaternion format. Moreover, comparing with the other existing nonlinear control strategies for the unmanned quadrotor, the proposed controller has the advantage of easy implementation and good robustness to the modeling uncertainties and unknown external disturbances by using the robust‐integral‐signum‐error method. The stability of the closed loop system is proved via the Lyapunov based stability analysis, and the proposed nonlinear robust controller can guarantee the asymptotic convergence of the quadrotor's attitude and position tracking errors. The effectiveness of the proposed agile flight control design is validated via real‐time experiments in comparison with the classical cascaded PID controller. And the experimental results show that the proposed controller achieves much higher flight control accuracy in agile flights.
The Intracellular and Extracellular Microenvironment of Tumor Site: The Trigger of Stimuli‐Responsive Drug Delivery Systems
Authors: Jing Xiaodong , Hu Hao , Sun Yanzhen , Yu Bing , Cong Hailin , Shen Youqing 
Published: January 2022

AbstractThe tumor microenvironment (TME), including intracellular and extracellular microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen content, and enzymatic activity) that are different from the normal physiological environment. These abnormal biochemical indicators can accelerate the heterogeneity of tumors, but on the other hand, they also provide opportunities for the design of intelligent drug delivery systems (DDSs). The TME‐responsive DDSs have shown great potential in reducing the side effects of chemotherapy and improving the curative effect of tumors. In this review, the abnormal biochemical indicators of TME are introduced in detail from both the extracellular and intracellular aspects. In view of the various physiological barriers encountered during drug delivery, the strategy of constructing TME‐responsive DDSs is discussed. By summarizing the typical research progress, the authors prospect the development of TME‐responsive DDS in the future.
Slightly broken higher spin symmetry: general structure of correlators
Authors: Gerasimenko Pavel , Sharapov Alexey , Skvortsov Evgeny 
Published: January 2022

Abstract
We explore a class of CFT’s with higher spin currents and charges. Away from the free or N = ∞ limit the non-conservation of currents is governed by operators built out of the currents themselves, which deforms the algebra of charges by, and together with, its action on the currents. This structure is encoded in a certain A∞/L∞-algebra. Under quite general assumptions we construct invariants of the deformed higher spin symmetry, which are candidate correlation functions. In particular, we show that there is a finite number of independent structures at the n-point level. The invariants are found to have a form reminiscent of a one-loop exact theory. In the case of Chern-Simons vector models the uniqueness of the invariants implies the three-dimensional bosonization duality in the large-N limit.
A multi-environment framework to evaluate the adaptation of wheat (Triticum aestivum) to heat stress
Authors: Telfer Paul , Edwards James , Taylor Julian , Able Jason A. , Kuchel Haydn 
Published: January 2022

AbstractKey messageAssessing adaptation to abiotic stresses such as high temperature conditions across multiple environments presents opportunities for breeders to target selection for broad adaptation and specific adaptation.AbstractAdaptation of wheat to heat stress is an important component of adaptation in variable climates such as the cereal producing areas of Australia. However, in variable climates stress conditions may not be present in every season or are present to varying degrees, at different times during the season. Such conditions complicate plant breeders’ ability to select for adaptation to abiotic stress. This study presents a framework for the assessment of the genetic basis of adaptation to heat stress conditions with improved relevance to breeders’ selection objectives. The framework was applied here with the evaluation of 1225 doubled haploid lines from five populations across six environments (three environments selected for contrasting temperature stress conditions during anthesis and grain fill periods, over two consecutive seasons), using regionally best practice planting times to evaluate the role of heat stress conditions in genotype adaptation. Temperature co-variates were determined for each genotype, in each environment, for the anthesis and grain fill periods. Genome-wide QTL analysis identified performance QTL for stable effects across all environments, and QTL that illustrated responsiveness to heat stress conditions across the sampled environments. A total of 199 QTL were identified, including 60 performance QTL, and 139 responsiveness QTL. Of the identified QTL, 99 occurred independent of the 21 anthesis date QTL identified. Assessing adaptation to heat stress conditions as the combination of performance and responsiveness offers breeders opportunities to select for grain yield stability across a range of environments, as well as genotypes with higher relative yield in stress conditions.
QTL identification, fine mapping, and marker development for breeding peanut (Arachis hypogaea L.) resistant to bacterial wilt
Authors: Qi Feiyan , Sun Ziqi , Liu Hua , Zheng Zheng , Qin Li , Shi Lei , Chen Qingzheng , Liu Haidong , Lin Xiufang , Miao Lijuan , Tian Mengdi , Wang Xiao , Huang Bingyan , Dong Wenzhao , Zhang Xinyou 
Published: January 2022

Abstract
Key message
A major QTL, qBWA12, was fine mapped to a 216.68 kb physical region, and A12.4097252 was identified as a useful KASP marker for breeding peanut varieties resistant to bacterial wilt.

Abstract
Bacterial wilt, caused by Ralstonia solanacearum, is a major disease detrimental to peanut production in China. Breeding disease-resistant peanut varieties is the most economical and effective way to prevent the disease and yield loss. Fine mapping the QTLs for bacterial wilt resistance is critical for the marker-assisted breeding of disease-resistant varieties. A recombinant inbred population comprising 521 lines was used to construct a high-density genetic linkage map and to identify QTLs for bacterial wilt resistance following restriction-site-associated DNA sequencing. The genetic map, which included 5120 SNP markers, covered a length of 3179 cM with an average marker distance of 0.6 cM. Four QTLs for bacterial wilt resistance were mapped on four chromosomes. One major QTL, qBWA12, with LOD score of 32.8–66.0 and PVE of 31.2–44.8%, was stably detected in all four development stages investigated over the 3 trial years. Additionally, qBWA12 spanned a 2.7 cM region, corresponding to approximately 0.4 Mb and was fine mapped to a 216.7 kb region by applying KASP markers that were polymorphic between the two parents based on whole-genome resequencing data. In a large collection of breeding and germplasm lines, it was proved that KASP marker A12.4097252 can be applied for the marker-assisted breeding to develop peanut varieties resistant to bacterial wilt. Of the 19 candidate genes in the region covered by qBWA12, nine NBS-LRR genes should be further investigated regarding their potential contribution to the resistance of peanut against bacterial wilt.