bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous injection of allogenic canine mesenchymal stem cells in 40 dogs: A safety assessment in veterinary clinical trials
Authors: Cho Hee-Seon , Song Woo-Jin , Li Qiang , An Ju-Hyun , Park Su-Min , Nam Aryung , Ahn Jin-Ok , Youn Hwa-Young 
Published: December 2022

Abstract
This study aimed to evaluate the adverse effects of allogeneic mesenchymal stem cell (MSC) transplanted via intravenous infusion in dogs and examine their long-term safety, including tumorigenesis. This study conducted a retrospective analysis of various clinical assessments, including physical examination, blood tests, and radiographs, and monitored the formation of neoplasms during a 6-month follow-up period in 40 client-owned dogs that received intravenous infusion of adipose tissue-derived MSCs (AT-MSCs) for the treatment of various underlying diseases between 2012 and 2018. No significant adverse effects of MSC therapy were detected by clinical assessment, blood tests, or radiographic examination in the 6-month follow-up period after the first MSC treatment. Additionally no new neoplasms were observed during this period. This study is the first to evaluate the long-term (≥ 6 month) safety aspects and risk of tumorigenesis for intravenous allogenic AT-MSC infusion. These results suggest that allogenic AT-MSC infusion can be relatively safe therapeutic approach in dogs.
Research on the relative characteristics of the application of relative criterion
Authors: Liu Jingang 
Published: December 2022

Abstract
Based on the mathematical quantification principle of the relative criterion idea of discrete quantity system, this paper studies the relative characteristics of the application of the relative criterion idea, and summarizes the relative characteristics of the relative group, time and space. Relative characteristics are inherent and ubiquitous in the application of relative criterion ideas to solve problems. In solving the simple and basic problems, the relative characteristics of different conclusions from the traditional thought show that the cognitive standard of the traditional thought is not an objective standard. It is accidental to use subjective absolute standards to solve objective problems and get correct results, not inevitable. In this paper, the theoretical basis of the relative characteristics is clarified by means of the theoretical formula of the relative criterion, and the different types of relative characteristics are illustrated by three examples. In order to clarify the application method of the relative criterion formula, the calculation process is given. The idea of relative criterion makes people re recognize the importance of standards and other relativity and objectivity. The formula of relative criterion theory lays a theoretical foundation for correctly solving practical problems.
Surface texturing of cutting inserts for turning of aluminium
Authors: Meliani Hasnaa , Gilbin Alexandre , Fontaine Michaël , Assoul Mohamed , Monteil Guy 
Published: December 2022

Abstract
This paper presents wet machining of wrought aluminium alloys with textured and non-textured tools. To improve the machining performance, textures were produced on rake face of uncoated cemented carbide by using femtosecond laser machining. Experiments were conducted on a computer numerical controlled lathe with each textured tool and then compared to conventional cutting tool. To evaluate the cutting performance of tested tools, the following criteria were considered: cutting forces evolution, rake face wear, flank face wear and chip formation. A significant decrease of flank wear about 90% is observed with textured tools with nanometric Laser Induced Periodical Surface Structures (LIPSS) and of 80% with double-scale structure (LIPSS + Dimples). Double-scale structured tool presents a lower cutting force in comparison with conventional cutting tool. An increase of shear angle value with tool textured with micrometric structure (Lines) is observed. A lower height of adhesion on rake face of the tool with LIPSS compared to other tested tools is found too. These results constitute another step in the purpose to design a new generation of tools for precision turning of aluminium alloys.
Factors associated with benefit finding in patients with lung cancer: a structural equation model analysis
Authors: Chen Chen , Chen Wen , Gu Hang , Wang Zheyun , Su Yunyan , Zhu Pingting 
Published: December 2022

Abstract
Purpose: This study aimed to test a hypothesized model of benefit finding (BF) of patients with lung cancer to explore how resilience, social support and coping affect BF.
Methods: 301 lung cancer patients hospitalized in two tertiary hospitals in Jiangsu pronvice were selected by convenient sampling method from July 2020 to February 2021. General information questionnaire, benefit finding scale, the Connor-Davidson resilience scale, social support rating scale and medical coping modes questionnaire were used to conduct in the investigation. Structural equation modelling was used to explore the effects of related factors on BF.
Results: The fit index of the hypothesized model was satisfactory. Resilience, social support, confrontation coping and acceptance-resignation coping had direct effects on BF. Moreover, social support had an indirect effect on BF through resilience, confrontation coping, acceptance-resignation coping and resilience-acceptance coping, resilience also had an indirect effect on BF through acceptance coping.
Conclusions: our results showed that the level of BF of lung cancer patients is low. Based on the results of model, medical staff should help them make good use of the social support system, enhance their resilience, correctly recognize the disease and face it positively, so as to improve the level of patients' BF and improve their quality of life.
Effects of Palladium Precursors on the Activity and Stability of Pd Catalysts for the Oxidation of Volatile Organic Components (VOCs)
Authors: Li Qingtao , Cai Qi , Li Xiaoyun , Han Enshan , Sun Yanmin , Cai Zhe , Lu Yanfei , Yu Haibin 
Published: December 2022

Abstract
To screen a suitable precursor, the effects of palladium salts on performance of Pd catalysts for the oxidation of volatile organic components (VOCs) were investigated. A series of catalysts were prepared by impregnating different palladium salts on alumina-coated cordierite. These catalysts were characterized by XRF, ICP, XRD, N2 adsorption-desorption, TEM, EDS Mapping, Raman spectroscopy, pulse-CO chemisorption, H2-TPR, NH3-TPD and XPS. Pulse-CO chemisorption and TEM showed that Pd species formed by Pd(NO3)2 have the highest metal dispersion, while the other two are aggregating. H2-TPR and XPS results showed that the catalyst prepared by Pd(NO3)2 has the most active sites. The catalytic oxidation activities of these catalysts were evaluated by ethane and propane. And the catalyst performed the best activity for ethane and propane was prepared by Pd(NO3)2. The chloride species in precursors can promote the aggregation of Pd species and poison the catalysts. The results show that Pd(NO3)2 is more suitable as the precursor of VOCs catalytic oxidation catalyst than PdCl2 and Pd(NH3)4Cl2.
Morphodynamical cell-state description via live-cell imaging trajectory embedding
Authors: Copperman Jeremy , Gross Sean , Chang Young Hwan , Heiser Laura , Zuckerman Daniel 
Published: December 2022

Abstract
Time-lapse imaging is a powerful approach to gain insight into the dynamic responses of cells, but the quantitative analysis of morphological changes over time is a challenge. Here, we exploit the concept of "trajectory embedding" to analyze cellular behavior using morphological feature trajectory histories, i.e., multiple time points simultaneously, rather than the more common practice of examining morphological feature time courses in single timepoint (snapshot) morphological features. We apply this approach to analyze live-cell images of MCF10A mammary epithelial cells after treatment with a panel of microenvironmental perturbagens that strongly modulate cell motility, morphology, and cell cycle behavior. Our morphodynamical trajectory embedding analysis constructs a shared cell state landscape revealing ligand-specific regulation of cell state transitions and enabling quantitative and descriptive models of single-cell trajectories. Additionally, we show that incorporation of trajectories into single-cell morphological analysis enables (i) systematic characterization of cell state trajectories, (ii) better separation of phenotypes, and (iii) more descriptive models of ligand-induced differences as compared to snapshot-based analysis. This morphodynamical trajectory embedding is broadly applicable for the quantitative analysis of cell responses via live-cell imaging across many biological and biomedical applications.
Non-curative resection for surgical T4b esophageal cancer: esophagectomy or non-esophagectomy?
Authors: Fujii Yusuke , Daiko Hiroyuki , Kubo Kentaro , Kanematsu Kyohei , Utsunomiya Daichi , Kurita Daisuke , Ishiyama Koshiro , Oguma Junya 
Published: December 2022

Abstract
Background
Recently, with the development of multidisciplinary treatment, the treatment outcomes of esophageal cancer (EC) have improved. However, despite advances in diagnostic imaging modalities, preoperative diagnosis of T4 EC is still difficult, and the prognosis of T4 EC remains very poor. In addition, the prognosis of surgical T4b EC (sT4b EC) after surgery remains unclear. In this study, we retrospectively reviewed sT4b EC.
Methods
We evaluated the clinical course of sT4b EC and compared palliative esophagectomy with R2 resection (PE group) with other procedures without esophagectomy (NE group) (e.g., only esophagostomy) for sT4b EC.
Results
Forty-seven patients with thoracic EC underwent R2 resection at our institution between January 2009 and December 2020. Thirty-four patients were in the PE group and 13 patients were in the NE group. The 2-year overall survival rate was 0% in the PE group and 20.2% in the NE group (p = 0.882). There was one case of long-term survival in the NE group that underwent surgery followed by definitive chemoradiation. Postoperative complications (Clavien–Dindo grade ≥3) were observed in 25 patients (73.5%) in the PE group and three patients (23.1%) in the NE group (p = 0.031). The median time to the initiation of postoperative treatment was 68.1 days in the PE group and 18.6 days in the NE group (p = 0191).
Conclusions
If EC is diagnosed as sT4b, palliative esophagectomy should be avoided because of the high complication rate and the lack of long-term survival.
Intensive Neurophysiological Rehabilitation System for Children with Cerebral Palsy: A Quasi-Randomized Controlled Trial
Authors: Kushnir Anna , Kachmar Oleh 
Published: December 2022

Abstract
Background. Recent research indicates that intensive rehabilitation tends to be effective for children with cerebral palsy (CP). Intensive Neurophysiological Rehabilitation System (INRS) is a multi-component approach that combines various interventions and addresses functional goals in different domains according to the International classification of functioning, disability, and health (ICF). This study aimed to examine the effectiveness of the INRS treatment in children with bilateral CP.
Methods. In this quasi-randomized controlled study, 48 children with spastic bilateral CP (age 5-12 years, GMFCS Levels I-IV, MACS Levels I-IV) were assigned to an experimental or control group in order they have been enrolled. The experimental group underwent INRS treatment and continued routine home treatment for four weeks. After the first evaluation, participants from the control group stayed on the waiting list for four weeks receiving home treatment and then starting the INRS treatment. Thereby, all participants were assessed three times. The primary outcome measure was a Gross Motor Function Measure 66 Item Set (GMFM). The secondary outcome measures included the Jebsen-Taylor Hand Function test, Box and Blocks test, ABILHAND-Kids Questionnaire, Self-care and Mobility domain of the Pediatric Evaluation of Disability Inventory, and the ankle dorsiflexion passive range of motion.
Results. There was a statistically significant increase in the GMFM score after the INRS treatment in both the experimental group (mean difference (MD) 2.0, P<0.01) and control group (MD 1.5, P<0.05), with a large size effect (partial eta squared (η2) =0.21 and η2=0.14). The mean difference between groups during the first study period was 2.89 points (p<0.01) in the GMFM score with a medium effect size (η2=0.12). Statistically significant superiority of the INRS treatment over home treatment was also obtained by Jebsen-Taylor Hand Function Test and the Box and Blocks Test in both dominant and non-dominant hands.
Conclusions. The study indicates that the INRS treatment can be beneficial for improving both gross motor functions and hand function in children with bilateral CP. Further longitudinal studies are required to evaluate the effects of the INRS treatment on the participation level of children with CP.
Trial registration: The study protocol was registered on ClinicalTrials.gov under the identifier: NCT04093180.
Development of 3D printed click-and-fit modular microfluidics for an integrated electrochemical platform
Authors: Anshori Isa , Munifah Kurniati Laeli , Ariasena Eduardus , Faiq Muhammad Azhar , Rizalputri Lavita Nuraviana , Harimurti Suksmandhira , Rajab Tati Latifah Erawati , Akbar Mohammad Rizki , Handayani Murni , Purwidyantri Agnes , Prabowo Briliant Adhi 
Published: December 2022

Abstract
In this article, we presented the development of fully modular microfluidic flow cells for an electrochemical using 3D printing. The proposed devices are potential for electrochemical measurements using a small sample volume on a fully portable, reusable, simply fabricated, low-cost, PDMS-free, and leakage-free flow cell. This concept offers a simple, controllable sample over the conventional electrochemical platform with a three-electrode system, which requires a considerable volume of samples or a non-controllable drop cast method for sequential protocols. We demonstrated an easy alignment and lock, namely, click-and-fit modular microfluidics, for quick and easy assembly and disassembly of flow cell modules using magnetic force instead of the screw, polymer glue, or resin. Two microfluidic modules were presented using tube- and syringe-flow cells (TFC and SFC) to integrate the screen-printed carbon electrodes (SPCE) in the electrochemical sensor. The proof-of-concept of the integrated sensor-microfluidic platforms was conducted under cyclic voltammetry using a tiny volume of a ferricyanide redox probe at only ~50 µL, differential pulse voltammetry, and square wave voltammetry. Implementing the proposed click-and-fit microfluidic modules in electrochemical detection achieves higher current peaks than droplet measurements. These flow cell modules are promising for biosensing applications using a small volume of physiological fluid samples.
Zero additional maintenance stormwater biofilters: from laboratory testing to field implementation
Authors: Prodanovic Veljko , Hatt Belinda , Fowdar Harsha , Al-Ameri Mohammed , Deletic Ana 
Published: December 2022

Abstract
Stormwater biofilters are one of the most widely used nature-based solutions for urban water management. In the last 20 years, biofilters have been extensively studied for their pollutant removal performance; however, their application in the field is limited by high maintenance requirements. In this work, we propose the concept of zero additional maintenance (ZAM) biofilters as a solution to this challenge. To understand the design and operation of ZAM biofilters, a three-stage research programme was conducted to (i) examine filter media configurations that could protect against surface clogging, (ii) test the pollutant removal performance of a variety of lawn grasses, and (iii) validate the laboratory findings through field monitoring. The results showed that a protective filter media layer delayed the onset of clogging. Five lawn grasses – Kenda Kikuyu, Empire Zoysia, Santa Ana Couch, Village Green Kikuyu and Palmetto Soft Leaf Buffalo – were found to effectively reduce nitrogen concentrations and meet other local pollution reduction requirements. Monitoring of three field-scale ZAM biofilters confirmed their high nutrient and heavy metal removal performance. Overall, the findings of these three studies confirm the potential for well-designed ZAM biofilters to achieve stormwater management requirements with no additional maintenance compared with standard street landscaping.
Localized Zosteriform bullous Pemphigoid on the Sites of a Healed Herpes Zoster: A Case Report and Literature Review
Authors: Al-Tarawneh Awad Hasan 
Published: December 2022

Background:
Localized zosteriform bullous pemphigoid is a rare variant of bullous pemphigoid that is considered a manifestation of Wolf`s isotopic response. Only a few cases have been reported. We add another case to the body of knowledge in order to shed the light on this uncommon variant of bullous pemphigoid.

Case Report:
A 67-year old female patient developed vesiculobullous lesions at the sites of healed herpes zoster. The patient was diagnosed as a case of zosteriform bullous pemphigoid based on the clinical presentation and skin biopsy findings.

Conclusion:
Zosteriform bullous pemphigoid is a rare manifestation of Wolf`s isotopic response. A Skin biopsy must be performed early to ensure proper diagnosis and management.
Gender Differences: Students' science process skills based on gender homogeneous class
Authors: Darmaji Darmaji , Astalini Astalini , Kurniawan Dwi Agus , Wirayuda Ricky Purnama 
Published: December 2022

The purpose of this study was to describe the ability of students' science process skills based on indicators, and to find out whether there were differences in students' science process skills based on gender homogeneous classes. This study was qualitative research with descriptive and inferential statistical approaches. Data collection was conducted at SMPN 9 Muaro Jambi with a population of all eighth grade students, and the research sample was 60 students consisting of 28 male students and 32 female students from 2 sample classes. The instrument used in this study was a science process skill observation sheet. The data processing technique used was descriptive statistics. The results show that, first, the science process skills of male and female students are in the good category based on basic and integrated science process skills indicated by the score of higher than 50% on each indicator. Secondly, there were also no differences in the science process skills between male students and and female students.
Analysis of Factors Affecting Healing of Acute Pharyngitis Viral Patients in Puskesmas I, Klungkung-Bali
Authors: Sutema Ida Ayu Manik Partha , Sudiari Made , Reganata I Gede Palguna 
Published: December 2022

Abstract
Antibiotic resistance is closely related to the inappropriate use of antibiotics, namely the indication, dose, frequency, and duration of use. Permenkes No. 5 of 2014 states that acute pharyngitis is given antibiotic therapy if it meets the diagnostic criteria using the center criteria, but this criterion is difficult to apply because doctors take longer to diagnose. Previous research at the Klungkung I Primary Health Center used diagnosis utilizing a swab test. It was found that 100% of bacterial pharyngitis patients were negative. The strategy of delaying antibiotics for 3 days can prevent antibiotic resistance, but in therapy, without antibiotics, it is important to increase the effectiveness of therapy, it is deemed necessary by the researchers to conduct a study to analyze the factors that affect the recovery of patients with acute pharyngitis, which are mainly caused by viruses. Analyzing the factors that affect the recovery of viral pharyngitis patients. The design of the cross-sectional study was through observation of the medical record data of patients who came to the Klungkung Primary Health Center I for 3 months and got diagnostic facilities using the swab test. Patients who got a negative swab test were analyzed for the factors that influenced their recovery. Anti-inflammatory variables, rest, and paracetamol significantly affected the recovery of acute pharyngitis patients (p <0.05), and the importance index in CART analysis found that paracetamol was the most influential, followed by rest, administration of vitamins, and anti-inflammatory. Antibiotics, anti-allergies, and cough medicines do not affect the recovery of patients with acute pharyngitis viral. Paracetamol has the most effect on patient recovery, followed by rest and administration of vitamins, anti-inflammatory has very little effect on the recovery in patients of acute pharyngitis viral.
Keywords: acute pharyngitis, cure, CART.
Protective Effect of Nigella sativa Seed Extract on Alloxan-Induced Mice Kidney Histology
Authors: Salim Hotimah , Sylvia Awwalia Evi , Ilham Putera Alam  
Published: December 2022

Abstract
Nigella sativa (N. sativa) has been used in traditional medicine, and several studies have been performed in the last decades to reveal its effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. This study aimed to evaluate the effects of Nigella sativa extract in an alloxan-induced mice model. This research was a true experimental post-test-only control group design. Eight-weeks old male Mus musculus were treated with alloxan (150 mg/ kg) by a single intraperitoneal injection to induce diabetes mellitus. At three days of injection, N. sativa extract (150 and 300 mg/kg) was administered via gavage for two weeks. The result of this study showed that N. sativa seed extract had a significant (P<0.05) nephroprotective effect on the kidneys based on the degree of kidney damage in alloxan-induced mice. This effect may be due to Nigella sativa’s antioxidant properties.
Keywords: Nigella sativa, histology kidney, oxidative stress
Symptoms of Mental Health during Covid-19 Survivors: A Cross-Sectional Study in Indonesia
Authors: Hapsari Pharmasinta Putri , Fatimatuz Zahra Oviary Satryo  , Lily Aina  , Nanda Ardianto  , Melinda Putri Amelia Rachman  , Fauzul Meiliani  , Eunice Marlene Sicilia Kundiman  
Published: December 2022

Abstract
The Covid-19 pandemic can influence the mental condition of patients and affect their immunity levels. This article aims to investigate the mental health symptoms and disorders of Covid-19 survivors. This was observational and cross-sectional research. A total of 175 respondents participated, 84% of them being women and 16% being men. Their work history includes health workers at 75.4% and others at 24.6%. Respondents who have experienced anxiety are 32%, sadness was 25.7%, fear was 22.9%, and panic was 14.3%. The logistic regression showed that all of the tested characteristics have no significant effect on the respondents’ mental states of anxiety, fear, and panic, with p-values ​​of 0.388, 0.893, and 0.166; 0.245, 0.691, and 0.353; 0.612, 0.410, and 0.828. However, from the test results, it was observed that gender has a significant effect on sadness with a p-value of 0.027 and OR value of 5.308 (CI = 1.204-23.399). The percentage of women respondents that experienced sadness was 29.3% and men respondents were 7.1%. Other characteristics, which are age and work history, have no significant effect on sadness, with p-values ​​of 0.650 and 0.844 respectively. There are no variables that affect anxiety, fear, and panic. Feelings of sadness in patients are influenced by gender.
Keywords: anxiety; Covid-19; mental disorder; mental health
TURNOVER INTENTION: A LITERATURE REVIEW
Authors: Asri Cahya Purnama 
Published: December 2022

The objective of this research is to determine the variables associated with turnover intention. I presented a literature study and as a result of this process, 23 articles are included and then examined the bibliographical references to check the validity of the inquiry. I identify several variables that affect turnover intention and affected by it.
Keywords: turnover intention; literature review