bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall Sexual Function in Dysmetabolic Obese Men with Low Testosterone
Levels Treated with Clomiphene Citrate
Authors: Pelusi Carla , Bartolomeo Nicola , Lisco Giuseppe , Baccini Margherita , Fanelli Flaminia , De Pergola Giovanni , Triggiani Vincenzo , Pagotto Uberto , Giagulli Vito Angelo 
Published: March 2022

Background:
Sexual disorders are the most common clinical manifestations of hypogonadism. Functional hypogonadism is the most frequent form, and clomiphene citrate (CC) has been recently introduced as a possible off-label therapeutic option for these patients.

Objective:
This study aimed to evaluate the effects of CC on the overall sexual function in dysmetabolic obese men with low testosterone (T) levels.

Methods:
This was a sub-study of a randomized, double-blind, cross-over, placebo-controlled trial that included twenty-four obese or overweight subjects with impaired glucose tolerance or type 2 diabetes and confirmed low total T (≤10.4 nmol/l) levels. Subjects were treated with CC or placebo (Plac) for 12 weeks, with an interval wash-out period of 6 weeks between treatments. All subjects were on metformin 2gr/day and a low-calorie diet. The between-treatment difference in the overall sexual function was assessed by IIEF-15 and a qADAM questionnaire.

Results:
IIEF-15 and qADAM questionnaire data were available for 18 individuals. In unadjusted analyses, CC was associated with lower IIEF-15 total, erectile function, and intercourse satisfaction domain scores than Plac. After adjustments for multiple variables, CC was associated with a higher IIEF-15 sexual desire domain score (+0.9 ± 0.8; p<.001) despite a lower qADAM score (-2.1 ± 0.9; p=.008) with respect to Plac. No differences were found for the other domains between groups.

Discussion:
The clinical significance of the absolute changes in IIEF-15 and qADAM scores during CC versus Plac is limited. However, CC has a reliable effect on sexual desire and is also as safe as Plac. According to the sample size, duration of follow-up, and inclusion criteria defined for the main study, further studies are therefore needed to assess the long-term efficacy of CC.

Conclusion:
Compared to Plac, CC was found to be associated with a neutral effect on overall sexual function.
Contribution of Glutathione-S-Transferases Polymorphism and Risk of
Coronary Artery Diseases: A Meta-Analysis
Authors: Sobha Santhi Priya , Kesavarao Kumar Ebenezar 
Published: March 2022

Background:
Oxidative stress is one of the risk components in the development of coronary
artery diseases (CAD). Genetic polymorphism in major antioxidant genes like Glutathione-
S-Transferases (GST) has been associated with increased CAD susceptibility and severity.

Objective:
To get a precise evaluation and to update the association, a meta-analysis on GST
(GSTM1, GSTT1, and GSTP1) polymorphism with CAD was performed. Moreover, the combined
effect of GSTM1/GSTT1 null genotypes on CAD risk has not yet been studied, but it has the highest
risk of developing diseases.

Materials and Method:
PubMed, Embase, and Web of Science were systematically searched for
eligible studies. Case-control studies in the English language and with genotypic frequency were
selected in order to provide data and calculate the odds ratio (OR). OR with 95% CI was calculated,
and a random effect model was used. NOS scale was used to assess the quality of the included
studies.

Results:
Meta-analysis indicated that the GSTM1 null genotype and GSTP1 (Ile105Val) polymorphism
is significantly associated with CAD risk with a pooled OR-1.38, p=0.01 for GSTM1 and
OR-1.19, p=0.04 for GSTP1. The dual null genotype of GSTM1-GSTT1 has the highest risk for
CAD development (OR-1.59, p=0.003), and there is no significant association between GSTT1 null
genotype with CAD. In the subgroup analysis, GSTM1 showed an increased risk for Asians (OR-
1.68, p=<0.01) and smokers (OR-1.98, p=<0.01). Publication bias was not observed.

Conclusion:
The findings suggest that the GSTM1 and GSTP1 polymorphism can be a predictive
factor for CAD risk, and a larger sample size is required further to confirm the association.
Sarcopenia: An Age-Related Multifactorial Disorder
Authors: Priyadarsini Nibedita , Nanda Pranati , Devi Sujata , Mohapatra Subarna 
Published: March 2022

Abstract:
Sarcopenia is a disease characterized by a gradual decline in skeletal muscle mass and
strength that accompanies the normal aging process. The disease is associated with various adverse
health outcomes in the geriatric population, such as prolonged hospital admission, disability, poor
quality of life, frailty, and mortality. Factors involved in the development of age-related sarcopenia
include anorexia, hormone level alterations, decreased neural innervation, low muscular blood
flow, cytokine dysregulation, altered mitochondrial activity, genomic instability, intracellular proteolysis,
and insulin resistance. Understanding the underlying mechanisms may facilitate the development
of efficient prophylactic and therapeutic strategies to improve the quality of life in elderly
individuals. Thus, the present review highlights literature regarding the mechanism of sarcopenia
development in elderly patients.
Loneliness as Risk Factor for Alzheimer´s disease
Authors: Ávila-Villanueva Marina , Gómez-Ramírez Jaime , Ávila Jesús , Fernández-Blázquez Miguel A. 
Published: March 2022

Abstract:
There is considerable empirical evidence that unequivocally points to loneliness as a
modifiable risk factor for the development of Alzheimer's disease and other related dementias. With
the emergence of the COVID-19 pandemic and the resulting lockdown and social distancing, there
has been a renewed interest in studying this topic. The present review examines the links between
loneliness and Alzheimer's disease, with particular emphasis on the mechanisms common to both
conditions.
Sleep Quality and Quality of Life Among Older Adults During COVID-19
Pandemic: A Cross-Sectional Study
Authors: Abdalla Pedro Pugliesi , Neto Elzier Sampaio de Queiroz , de Souza Lage Ana Carolina Silveira , Gomes Sérgio , de Freitas Maria das Dores Bezerra , Pedro-Costa Simão , Machado Dalmo Roberto Lopes , Oliveira José , Mota Jorge , Bohn Lucimere 
Published: March 2022

Background:
Although home confinement reduces the number of SARS-CoV-2 infections,
it may negatively impact the psychological and physical health of older adults.

Objective:
The present study attempted to describe the quality of life (QoL) of older adults before
and during the COVID-19 outbreak, focusing on evaluating QoL, physical activity, sitting time,
and sleep quality during home confinement.

Method:
The present study was conducted in 1,063 older adults (91 % females) enrolled in a Brazilian
social program. They were interviewed for QoL (EQ-5D), physical activity (international
physical activity questionnaire-short), and sleep quality [Pittsburgh sleep quality index (PSQI)] after
11.6 ± 2.4 weeks of confinement. Logistic regression confirmed changes in QoL.

Results:
The QoL (86.5 ± 14.7) decreased significantly during confinement (66.0 ± 21.0; P <
0.001), whereas the PSQI global score was 6.8 ± 3.9 points. Older adults spent 18.7 ± 29.8 min/day
in moderate to vigorous physical activity, whereas they spent 325.5 ± 144.4 min/day sitting. The
PSQI global score [odds ratio (OR): 1.10], sitting time (OR: 1.001), and diseases (OR: 1.23) were
significantly associated with low QoL (P < 0.05).

Conclusion:
Confinement has a deleterious effect on QoL, which is influenced by quality of sleep,
sitting time, and disease. Awareness regarding the significance of sleep and physical exercise in
older adults can mitigate the damage to their health during confinement.
Pemberdayaan pengrajin tenun
Authors: Putridiani Siti Ativa , Suryono Yoyon 
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan pemberdayaan masyarakat, inovasi dalam membuat kerajinan tenun, dan faktor-faktor pendukung serta penghambat keberhasilan pemberdayaan masyarakat sentra kerajinan tenun di Desa Wisata Gamplong. Jenis penelitian adalah penelitian kualitatif metode studi kasus. Sumber data yang diteliti adalah ketua paguyuban “TEGAR”, pengelola rumah kerajinan, dan pengrajin tenun. Pengumpulan data melalui wawancara, observasi serta dokumentasi. Analisis data dilakukan dengan pengumpulan data, reduksi data, penyajian data, dan kesimpulan. Instrumen yang digunakan adalah pedoman wawancara, pedoman observasi, dan dokumentasi. Keabsahan data dilakukan dengan triangulasi data, sumber dan teknik. Hasil penelitian menunjukkan bahwa proses pemberdayaan pengrajin tenun di Sentra Kerajinan desa wisata Gamplong yaitu melakukan pelatihan, melakukan pendampingan, dan evaluasi. Inovasi yang dilakukan yaitu inovasi produk yang menghasilkan design unik dan baru untuk diaplikasikan pada kerajinan tenun. Faktor pendukungnya ialah adanya event-event, potensi alam, kerajinan tenun, dan ATBM. Sedangkan faktor penghambat yaitu minimnya dukungan dari masyarakat, generasi penerus dan persaingan harga Empowerment of weaving craftsmen AbstractThis study aims to describe the process of community empowerment, innovation in making woven crafts, and supporting factors and obstacles to the success of community empowerment of weaving craft centers in Gamplong Tourism Village. This type of research is a qualitative research case study method. The data sources studied were "TEGAR" community leaders, managers of craft houses, and weaving craftsmen. Data collection through interviews, observation and documentation. Data analysis with data collected, data reduction, data presentation, and conclusions. The instruments used are interview guides, observation guidelines, and documentation. The validity of the data is done with triangulation of data, sources and techniques. The results of the study show that the process of empowering weaving craftsmen in the Gamplong tourism village Craft Center is conducting training, providing assistance, and evaluating. The innovation that is done is product innovation that produces a unique and new design to be applied to weaving crafts. The supporting factors are the existence of events, natural potential, weaving crafts, and ATBM. While the inhibiting factors are the lack of support from the community, future generations and price competition.
Pencapaian pemahaman orang tua dalam membimbing tata krama anak autis
Authors: Swandari Dian Ngesti , Mumpuniarti Mumpuniarti 
Published: March 2022

Tata krama merupakan bagian dari keterampilan sosial yang mengajarkan sikap baik dalam pergaulan dari segi bahasa maupun tingkah laku. Tata krama perlu diperkenalkan pada anak autis agar mereka dapat membedakan perilaku baik dan perilaku yang kurang tepat untuk dilakukan. Orang tua memegang peranan penting dalam membimbing tata krama anak autis. Oleh karena itu diupayakan agar orang tua memahami cara untuk mendampingi dan membimbing tata krama anak autis. Salah satu cara yang efektif dalam pendampingan latihan tata krama anak autis adalah dengan pembelajaran observasional, di mana orang tua berperan sebagai model atau contoh yang akan ditiru oleh anak autis. Adapun tujuan dari latihan tata krama dengan pembelajaran observasional ini adalah agar anak berlatih tata krama dengan melihat orang tua sebagai model kemudian anak berlatih tata krama berdasar apa yang dilihatnya pada orang tua. Jadi orang tua memiliki peran ganda yaitu sebagai model dan pendamping latihan sehingga orang tua dapat memahami fungsi dari peran orang tua anak autis. Metode yang digunakan dalam penelitian ini adalah penelitian tindakan yang melibatkan semua pihak secara langsung dan dimaksudkan untuk meningkatkan keterampilan pada semua pihak yang terlibat. The achievement of parents comprehension in guiding autism children manners AbstractManners are parts of social skills that teach good attitude in association in terms of language and behaviour. Manners need to be introduced to autistic children so that they can distinguish between good behaviour and inappropriate behaviour to do. Parents play an important role in guiding the manners of autistic children. Therefore efforts are made so that parents understand how to assist and guide the behaviour of autistic children. One effective way of mentoring autism practices for children with autism is observational learning, where parents act as models or examples that will be imitated by autistic children. The aim of this observational learning is that children can practice manners by seeing their parents as models and at the end, they can apply what they see from their parents. Therefore, parents have two roles, that are as a model and a training companion so that parents can understand the role function of parents of children with autism. The method used in this research is action research that involves all parties directly and intended to improve the skills of all parties involved.
Formación inicial y carrera docente en América Latina: una mirada global y regional
Authors: Vaillant Denise , Manso Jesús 
Published: March 2022

El presente ensayo teórico surge de una revisión sistemática de la literatura realizada por los autores a partir de las referencias recientes. Tiene por finalidad contribuir a la reflexión y a un diálogo informado acerca de la carrera y la formación de docentes en América Latina a la luz de las tendencias internacionales. Se ofrece, en primer lugar, una revisión sistemática sobre las tendencias y los distintos aspectos que caracterizan las carreras docentes a nivel global. Se parte de la premisa de que la formación docente no puede analizarse de manera aislada, sino que debe estudiarse a partir del escenario en el cual se construye. En una segunda instancia, se centra la mirada en los aspectos más directamente vinculados con la preparación de maestros y profesores en la región. Finalmente, se presentan una serie de sugerencias que permitirían la mejora de la formación en el contexto más amplio de la transformación de las carreras docentes en América Latina.
Innovación disruptiva y Nueva Identidad Docente Modelo AIE-UCA de formación por aptitudes
Authors: Peregalli Andrés , Rodríguez Hernan 
Published: March 2022

La profesionalización docente requiere de una transformación innovadora en la formación inicial que reformule la identidad y supere una formación academicista propiciando un aprendizaje multidimensional y situado. Este artículo describe los resultados del modelo innovador de formación docente inicial AIE-UCA (Aprendizaje Inclusivo y Efectivo-Universidad Católica Argentina), desarrollado para superar las limitaciones de los modelos tradicionales. A tales efectos desarrolla el concepto de innovación, las condiciones institucionales que posibilitan su realización y las características que conforman el desarrollo de la profesionalidad (nueva identidad). Se realiza un análisis ex post facto mediante una metodología mixta sustentada en gran medida en el análisis cualitativo de contenido de desempeños de estudiantes durante los primeros cuatro años de despliegue de la experiencia. Los resultados evidencian una formación inicial innovadora en la cual los futuros educadores desarrollan conscientemente capacidades profesionales que integran conocimientos disciplinares, experiencia práctica y posicionamiento ético-político. También aportan evidencias sobre las transformaciones organizacionales que posibilitaron una experiencia innovadora inclusiva y efectiva, con indicadores alentadores de eficiencia interna y de reducción sustantiva de la brecha educativa entre los estudiantes que forman parte de la experiencia.
EFL Teachers’ Work Tasks Motivation towards Class Preparation, Teaching, and Evaluation of Students
Authors: Erarslan Ali , Asmalı Mehmet 
Published: March 2022

Abstract

Introduction: Motivation plays a central role in teachers’ instructional practices. Teaching quality and teacher effectiveness contribute positively to student achievement. In line with this, teachers face several tasks in their profession, and they exhibit various motivational levels consisting of different motivational constructs, such as intrinsic, introjected, identified, external motivation, and amotivation. Therefore, this study aims at revealing Turkish EFL teachers’ motivations towards the work tasks of class preparation, teaching, and evaluation of students, which all teachers have to conduct in their profession.

Methods: To collect data, Work Tasks Motivation Scale for Teachers was used. The sample consisted of 1786 EFL teachers teaching throughout Turkey in all types of schools and locations across seven geographical regions.

Results: The quantitative data revealed that motivational constructs vary according to the work tasks of class preparation, teaching, and evaluation of students indicating that teacher motivation has a multifaceted nature and is a non-uniform construct.

Discussion: The results indicated that Turkish EFL teachers did not value the task of classroom preparation, while the task of evaluation of students seemed to be valued. Gender-based differences also indicated that female teachers had higher amotivation and external regulation levels towards classroom preparation and teaching despite their higher levels of intrinsic motivation towards evaluation of students. In addition, considering age variable, the younger group of EFL teachers were found to be more intrinsically motivated towards teaching and evaluation of students compared to the older groups while being more amotivated towards the task of classroom preparation.

Limitations: Despite the high number of the participants, the findings of the study are limited to the analyses of quantitative data as the main source.

Conclusions: The findings of the study indicated that EFL teachers working in all regions and cities of Turkey demonstrated high levels of a) amotivation towards classroom preparation, b) introjected regulation towards teaching, and c) intrinsic motivation towards evaluation of students. Moreover, EFL teachers’ work task motivations displayed variations based on their gender, their age, the location and the type of their school. Further research could investigate potential reasons for the differences in EFL teachers’ motivation levels while further increasing the reliability of the results by integrating qualitative data through interviews, observations, or teacher diaries.
The Effectiveness of Mindfulness-Based Thriving Programs on High School Students’ Perceived Stress, Mindfulness, Thriving and Self-Efficacy Levels
Authors: Özcan Neslihan Arıcı 
Published: March 2022

Abstract

Introduction: Adolescence is a period of rapid change marked by increased stress levels. Individuals with high self-efficacy better alleviate the effects of the stress of this period by exerting conscious control over their own thoughts, behaviours and feelings – a trait strongly associated with mindfulness. In this regard, the concept of mindfulness-based self-efficacy has been a much-researched area in recent students. Mindfulness practices ensure individuals with vitality and energy since they learn to become more open and engaged. In this respect, mindfulness is associated with thriving. This experimental research investigates the effects of the Mindfulness-Based Thriving Program (MTP) on high school students’ perceived stress, mindfulness, thriving and self-efficacy levels.

Methods: The study was conducted with 17 randomly assigned, female 11th grade students (X̄=16.62 for experimental group, X̄=16.77 for control group), who acquired educational support in Uskudar Municipality Youth Academy in the 2019-2020 academic year. The inclusion criteria included scoring highly on the Perceived Stress Scale (PSS) and scoring lowly on the Mindfulness Attention Awareness Scale (MAAS), Thriving Scale (TS) and Self-Efficacy Scale (GSES) in a pre-test assessment. The experimental group (n=8) received a six-session MTP intervention developed by the researcher, while the control group (n=9) received no intervention. To determine the immediate and long-term effects of the MTP, all participants completed post-tests (PSS, MAAS, TS, GSES) two months after the program.

Results: The 6-week MTP applied to adolescents was significantly effective in decreasing perceived stress and increasing mindfulness, thriving and self-efficacy levels.

Discussion: All findings were supported by the relevant literature and recommendations on their possible application have been given.

Limitations: Scores obtained from the scales, the narrow range of the sample (only 11th grade female students), the lack of a placebo group to support reliability and the lack of a comparable program for the current one all indicated the limitations of the study.

Conclusions: The 6-week MTP applied to adolescents showed the effectiveness in decreasing perceived stress and increasing mindfulness, thriving and self-efficacy levels. In this regard, thriving and mindfulness together have an important role in the development of self-efficacy and in decreasing perceived stress during adolescence. Thus, all these conclusions highlight the potential contribution of eclectic mindfulness practices for adolescence.
Organizational Justice, Perceived Stress and Leader Support as Predictors of Teachers’ Job Satisfaction
Authors: Çelik Hayriye Reyhan , Kalkan Ömür Kaya 
Published: March 2022

Abstract

Introduction: Teachers’ job satisfaction which has a positive effect on the quality of education, students, teachers and schools is significant for the successful functioning of schools. On the other hand, the increase in the level of dissatisfaction causes disciplinary problems, inefficiency, job dissatisfaction, alienation from the job, or leaving the job. Therefore, research on teachers’ job satisfaction can help to understand the general and specific aspects of teachers’ job satisfaction, which in turn this information can provide a scientific basis for solving problems.

Methods: The study uses quantitative research methodologies based on a correlational research. The research data obtained the convenience sampling method from 396 teachers who work for public schools in the province of Denizli in Turkey. Multiple regression was used for analysis.

Results: The results of the study showed that organizational justice, perceived stress and leadership support are all significant predictors of teachers’ job satisfaction. The relative importance order of the specified variables in predicting teachers’ job satisfaction is organizational justice, perceived stress and leader support, respectively. Predictor variables account for approximately 50.4% of the total variance in teachers’ job satisfaction.

Discussion: Within the scope of the research, the relationships determined between job satisfaction, organizational justice, perceived stress and leader support are consistent with the results of the research conducted on teachers and other professional groups in the literature. Implications of the study results were discussed in detail.

Limitations: In addition to its contributions to the literature, the research also has some limitations. Basically, correlational research results can be useful to reveal the existing relationships between variables, but it should be emphasized that these relationships are not causal ones. Furthermore, the use of convenience sampling method among non-random sampling methods can be considered as another limitation. However, the consistency of the relationships determined between the variables of the study with the existing literature indicates that the bias due to this limitation is relatively low.

Conclusion: The results of the study indicated that the order of relative importance in educational policies and practices that will take teachers’ job satisfaction into account should be structured as organizational justice, perceived stress and leader support. However, it is thought that holistic approaches that include all variables can be more effective, since variables of organizational justice, perceived stress and leader support are significantly associated with teachers’ job satisfaction.