bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Metode Cooperative Script Terhadap Kemampuan Berbicara Pada Siswa Kelas IX SMP Negeri 1 Selong Tahun Pelajaran 2020/2021
Authors: Wijaya Herman , Islahuddin  , H.A. Gani Ramlah , Supratmi Nunung 
Published: December 2022

enelitian ini bertujuan untuk mengetahui Pengaruh Metode Cooperative Script terhadap kemampuan keterampilan berbicara siswa Kelas IX SMP Negeri 1 Selong tahun pelajaran 2021. Jenis penelitian yang digunakan dalam penelitian ini berbentuk eksperimen dengan quasi eksperimental. Populasi dalam penelitian ini adalah seluruh siswa Kelas IX SMP Negeri 1 Selong Tahun Pelajaran 2020/2021. Jumlah Kelas IX SMP Negeri 1 Selong ada 2 kelas dengan jumlah keseluruhan 60 siswa. Selanjutnya teknik pengambilan sampel yang digunakan adalah teknik simple random sampling. Adapun kelas yang terpilih sebagai sampel dalam penelitian ini adalah kelas IXa sebagai kelas eksperimen dan kelas IXb sebagai kelas kontrol. Teknik yang digunakan untuk pengumpulan data adalah tes. Pengujian dilakukan secara statistik terhadap hasil post-test masing-masing kelompok dengan menggunakan uji-t menunjukkan nilai thitung= 2,7 dan ttabel= 1,671 yang berarti thitung ≥ ttabel. Maka hasil pengujian hipotesis adalah Ho ditolak dan Ha diterima, menunjukkan ada pengaruh yang signifikan kelas yang menggunakan metode Cooperative Script dan konvensional. Dengan demikian dapat disimpulkan bahwa pembelajaran menggunakan metode Cooperative Script berpengaruh terhadap kemampuan keterampilan berbicara siswa pada pembelajaran bahasa Indonesia khususnya pada materi diskusi Kelas IX SMP Negeri 1 Selong tahun pelajaran 2020/2021.
Pengaruh Penggunaan Media Animasi terhadap Keterampilan Menceritakan Kembali Isi Fabel Siswa Kelas VII SMP Negeri 2 Sijunjung
Authors: Sisi Sisi Febria Agami , Fitri Rahayu , Septia Emil 
Published: December 2022

Penelitian ini betujuan untuk mendeskripsikan pengaruh penggunaan media animasi terhadap keterampilan menceritakan kembali isi fabel siswa kelas VII SMP Negeri 2 Sijunjung. Jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan metode eksperimen. Desain penelitian ini adalah One Group Pretest-Posttest Design. Populasi penelitian ini adalah siswa kelas VII SMP Negeri 2 Sijunjung. Sampel dalam penelitian ini adalah siswa kelas VII SMP Negeri 2 Sijunjung yang berjumlah 20 orang. Data dalam penelitian ini adalah skor keterampilan menceritakan kembali isi fabel sebelum dan sesudah menggunakan media animasi pada siswa kelas VII SMP Negeri 2 Sijunjung. Hasil penelitian ini dapat disimpulkan sebagai berikut ini. Pertama, keterampilan menceritakan kembali isi fabel siswa kelas VII SMP Negeri 2 Sijunjung sebelum menggunakan media animasi diperoleh nilai rata-rata hitung 58,09 berada pada rentangan 56-65% pada skala dengan kualifikasi cukup (C). Kedua, keterampilan menceritakan kembali isi fabel siswa kelas VII SMP Negeri 2 Sijunjung sesudah menggunakan media animasi diperoleh nilai rata-rata 71,66 berada pada rentangan nilai 66-75% dengan pada skala 10 dengan kualifikasi lebih dari cukup (LDC). Ketiga, berdasarkan uji-t disimpulkan bahwa terdapat pengaruh yang signifikan penggunaan media animasi terhadap keterampilan menceritakan kembali isi fabel siswa kelas VII SMP Negeri 2 Sijunjung setelah hasil pengujian yang membuktikan bahwa thitung> dari ttabel yaitu 5,71 1,73.
Sexual quality of life in hormonotherapy for breast cancer patients
Authors: Silva Pedro Paulo Perroni da , Capassi Ana Clara Salviato , Haddad Carolina Federicci , Santos Larissa Araujo , Maia Marina Vieira , Hatamoto Nadia Yumi , Pires Luis Antonio , Delgado Gilson Luchezi 
Published: December 2022

ABSTRACT
Objectives: To evaluate how hormonal therapy can impact breast cancer patients sexual quality of life and compare two widely used therapeutic agents: anastrozole and tamoxifen. Studies so far have evaluated the side effects of such therapy on patients general quality of life, but literature remains scarce regarding the impact it has on sexual aspects. We believe there is a demand for a detailed view of these aspects since most patients undergo these treatments for at least five years.
Material and Methods: Transverse observational study evaluated in 2019, 41 women with a history of breast cancer, all of them undergoing hormonal therapy. Group presented a mean age of 55.4 years (35 to 77 years); those in menopause with a mean time of menopause of 10.92 years (2 to 28 years). Thirty-eight women lived maritally and/or were sexually active. The mean duration of treatment was 36.84 months. We analyzed data in pre-and postmenopausal women, evaluating the results of questionnaires with general parameters (age, treatment time, general quality of life, adaptation to therapy) as well as specific instruments for evaluation of sexual dysfunction (FSDS-R) and quality of life with specific aspects for breast cancer (FACT-B). The results were placed in 2×2 contingency tables comparing the group receiving tamoxifen versus anastrozole.
Results and Conclusion: Tamoxifen compared to anastrozole is a drug with apparent less impact on most common sexual dysfunctions (orgasm, dyspareunia, and feeling good quality of sex life), following those already published in international literature. We found no impact on physical, socio-familiar, and emotional well-being. Finally, we conclude that the results of this study significantly contribute to the choice of adequate therapeutic agent and highlight the need to bring this topic during routine consults and to the decision with the patient for the best suited treatment option.
Lanolin-based dexpanthenol cream, topical hydrocortisone or observation in the prevention of capecitabine-induced hand-foot syndrome: a phase III trial
Authors: La-Scala Cintia Sayuri Kurokawa , Malzyner Artur , Lima Carmen Silvia Passos , Rosa Daniela Dornelles , Franke Fabio André , Peria Fernanda Maris , Borges Giuliano Santos , Girotto Gustavo Colagiovanni , Brust Leandro , Gomes Magda Conceição Barbosa , Calux Nilciza Maria de Carvalho Tavares , Sales Roberto Magnus Duarte , Freitas Ruffo , Serrano Sergio Vicente 
Published: December 2022

ABSTRACT
Introduction: The use of capecitabine is associated with hand-foot syndrome (HFS). Since there is anecdotal evidence that lanolin-based creams and topical steroids are useful for the treatment of HFS, we conducted a three- arm phase III trial to compare observation, lanolin-based cream with dexpanthenol (L-D), and topical hydrocortisone in the prevention of HFS.
Material and Methods: Patients with breast or colorectal cancer with indication to use capecitabine as a single agent or in combination were randomized in an open-label fashion to one of the three arms. The initial capecitabine dose was 1,000 or 1,250mg/m2, according to the physicians discretion and clinical practice, and dose adjustments followed the local label. The primary endpoint was the frequency of HFS of any grade in the intent-to-treat population, whereas quality of life (QoL), change from baseline in performance status and adverse events were secondary endpoints.
Results: Mean age among the 595 patients randomized was 58 years, and 69% were women. 37% of patients had advanced breast cancer and 63% of patients had colorectal cancer. Capecitabine was used as a single agent in 67% of patients; among the remaining 33% of patients, 82% were treated with oxaliplatin-based combinations. HFS of any grade was seen in 35.6% of patients in the observation group, 24.9% with L-D, and 34.3% with hydrocortisone (p=0.039). The unadjusted odds ratio for the frequency of HFS in the arm treated with L-D was 0.60 (95%CI, 0.39 to 0.92). Only between 2.6% and 9.4% of patients had grade 3 HFS. There were no statistically significant differences in mean change from baseline in any of the QoL scores, the distribution of performance status, or the frequency of adverse events among the three arms.
Conclusion: L-D could be considered a standard strategy in the attempt to prevent capecitabine-induced HFS.
Mental Patient
Authors: Gosselin Abigail 
Published: December 2022

A philosopher who has experienced psychosis argues that recovery requires regaining agency and autonomy within a therapeutic relationship based on mutual trust.
In Mental Patient, philosopher Abigail Gosselin uses her personal experiences with psychosis and the process of recovery to explore often overlooked psychiatric ethics. For many people who struggle with psychosis, she argues, psychosis impairs agency and autonomy. She shows how clinicians can help psychiatric patients regain agency and autonomy through a positive therapeutic relationship characterized by mutual trust. Patients, she says, need to take an active role in regaining their agency and autonomy—specifically, by giving testimony, cons
tructing a narrative of their experience to instill meaning, making choices about treatment, and deciding to show up and participate in life activities.
Gosselin examines how psychotic experience is medicalized and describes what it is like to be a patient receiving mental health care treatment. In addition to mutual trust, she says, a productive therapeutic relationship requires the clinician's empathetic understanding of the patient's experiences and perspective. She also explains why psychotic patients sometimes feel ambivalent about recovery and struggle to stay committed to it. The psychiatric ethics issues she examines include the development of epistemic agency and credibility, epistemic justice, the use of coercion, therapeutic alliance, the significance of choice, and the taking of responsibility. Mental Patient differs from straightforward memoirs of psychiatric illness in that it analyses philosophic issues related to psychosis and recovery, and it differs from other books on psychiatric ethics in that its analyses are drawn from the author's first-person experiences as a mental patient.
Extensive Foveoschisis in an Emmetropic Patient Associated with Vitreomacular Traction: A Case Report
Authors: Katsimpris Andreas , Karamaounas Aristotelis , Mitsopoulou Dimitra , Georgalas Ilias , Petrou Petros 
Published: December 2022

Aims: To report a rare case of foveoschisis caused by vitreomacular traction in a young emmetropic female patient.
Presentation of the Case: A 37-year-old woman, without any systemic or ocular disorders, presented with progressively reduced visual acuity in her right eye over the last 3 months. Best-corrected visual acuity (BCVA) was counting fingers in the right eye. Optical coherence tomography revealed foveoschisis with foveal detachment in her right eye, which was successfully treated with pars plana vitrectomy without internal limiting membrane peeling and gas tamponade. Three months post-operatively the BCVA improved to 6/12.
Discussion and Conclusion: Although high myopia is the main cause of foveoschsis, vitreomacular traction can rarely be associated with foveoschisis, specially in young patients without myopia or any other ocular history. In these cases pars plana vitrectomy with extensive posterior vitreous detachment induction may have favorable visual outcomes.
Functional Assessment of Fetal Heart by Echocardiography in Maternal Diabetes Mellitus
Authors: Mohamed Arwa Ashraf , Shaaban Aliaa El-Sayed , Abdelaal Mohamed Ahmed , Salama Mai Mohamed 
Published: December 2022

Background: Diabetes mellitus constitutes a significant risk for the fetus if present in pregnant woman. Tissue Doppler imaging (TDI) is less dependent on loading conditions, so it is more accurate for assessment of cardiac function and can detect subclinical fetal cardiac dysfunction. The aim of this work was to assess fetal heart functional abnormalities (left ventricular systolic and diastolic function, right ventricular systolic and diastolic function) and their relation to maternal glycemic control.
Methods: This prospective case-control study was carried out on 30 diabetic mothers either with pregestational diabetes (PGDM) or gestational diabetes (GDM) and 20 healthy mothers in the third trimester. Patients were subdivided in to two groups: group I: poorly controlled diabetic pregnant mothers (17 cases) and group II: well-controlled diabetic pregnant mothers (13 cases). Patients were subjected to fetal echocardiography (left ventricular systolic and diastolic function assessment, right ventricular systolic and diastolic function assessment).
Results: There was significantly higher values regarding fasting blood glucose level, 2 hours post-prandial blood glucose level and HbA1c in poorly controlled patients versus well controlled (P value < 0.001). It was noticed that E` and A` wave velocities of the mitral annulus, MPI and IVRT were significantly higher in fetuses of groups I, II than fetuses of group III (P <0.05). Fetuses of groups I, II showed significantly lower E/E` ratio when compared to fetuses of group III (P <0.05).
Conclusions: By using tissue Doppler imaging at around 28 weeks of gestation, it was discovered that the systolic and diastolic function indices measures were different in foetuses of diabetic mothers than in normal foetuses. Despite having well-controlled diabetes, the echocardiographic results of uncomplicated non-diabetic women's foetuses were significantly different from those of diabetic women's foetuses.
On shame and the perceived credibility of sexual assault allegations
Authors: Keskin Gizem , Baker Alysha , Lloyd E. Paige , Krank Liliana , ten Brinke Leanne 
Published: December 2022

AbstractDespite the high incidence of sexual assault, doubt about allegations is common. Previous research suggests that victims expressing positive or no emotion are perceived as less credible than those expressing negative emotions. However, little is known about which specific negative emotional expressions contribute to credibility in this context. In two studies (N = 623), participants read a date rape vignette. The alleged victim's statement was paired with a picture of a female person expressing either shame, sadness, or no emotion. Participants rated the credibility of her account and completed a measure of rape myth acceptance. Controlling for rape myth acceptance, allegations were perceived as more credible when accompanied by an expression of shame versus sadness (a negative, low arousal control condition). It is critical to be aware of the shame‐credibility bias in this context to intervene and support those who have experienced sexual assault.
Organic Heterocyclic Strategy for Precisely Regulating Electronic State of Palladium Interface to Boost Alcohol Oxidation
Authors: You Zhihu , Zhao Zijie , Zhang Qiankun , Zhang Chuanhui , Long Xiaojing , Li Daohao , Xia Yanzhi 
Published: December 2022

AbstractExploring highly‐efficient palladium (Pd)‐based electrocatalysts for the alcohol oxidation reaction (AOR) is crucial yet challenging for chemists due to the vague Pd interface with an uncontrollable electronic environment. Herein, an organic heterocyclic strategy is used for the first time to modulate the electronic state of Pd electrocatalysts by anchoring Pd nanoparticles to conjugated microporous polymers (CMPs) with varied S‐, N‐, O‐, or S, N‐heterocycles. Among these CMPs, the S, N‐containing thiazole heterocyclic polymer SNC with Pd catalyst exhibits highly‐efficient current densities of 1575.0 mA mgPd−1 for methanol oxidation and 1071.0 mA mgPd−1 for ethanol oxidation, which are among the highest performance in the heterocyclic modulated Pd systems and surpass the commercial Pd black catalyst. Detailed theory calculations suggest that although the furan (O‐heterocycle) polymer OC has the strongest charge transfer (0.057 |e|) with the Pd cluster, the moderate electron transfer (0.041 |e|) of the Pd/SNC heterojunction with an S···N···Pd noncovalent interaction shows the best catalytic reaction kinetics. Moreover, the d‐band of the Pd/SNC system is closer to the volcano vertex than its counterparts. These results indicate that appropriate electron transfer intensity regulation of Pd electronic state by well‐defined heterocyclic structures may significantly improve AOR activity.
Lithium Superionic Conduction in BH4‐Substituted Thiophosphate Solid Electrolytes
Authors: Jang Yong‐Jin , Seo Hyungeun , Lee Young‐Su , Kang Sora , Cho Woosuk , Cho Young Whan , Kim Jae‐Hun 
Published: December 2022

AbstractCompared with conventional liquid electrolytes, solid electrolytes can better improve the safety properties and achieve high‐energy‐density Li‐ion batteries. Sulfide‐based solid electrolytes have attracted significant attention owing to their high ionic conductivities, which are comparable to those of their liquid counterparts. Among them, Li thiophosphates, including Li‐argyrodites, are widely studied. In this study, Li thiophosphate solid electrolytes containing BH4− anions are prepared via a simple and fast milling method even without heat treatment. The synthesized materials exhibit a high ionic conductivity of up to 11 mS cm−1 at 25 °C, which is much higher than reported values. To elucidate the mechanism behind, the thiophosphate local structure, whose effect on the ionic conductivity remains unclear to date, is investigated. Raman and solid‐state NMR spectroscopies are performed to identify the thiophosphate local structure in the sulfide samples. Based on the analysis results, the ratios of the different thiophosphate units in the prepared electrolyte samples are determined. It is found that the thiophosphate local structure can be varied by changing the amount of LiBH4 and the milling conditions, which significantly impact the ionic conductivity. The all‐solid‐state cell with the prepared solid electrolyte exhibits superior cycle and rate performances.
Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma
Authors: Yuan Guangda , Hu Bowen , Ma Jun , Zhang Chuanyu , Xie Hongya , Wei Tengteng , Yang Yong , Ni Bin 
Published: December 2022

AbstractObjectiveAberrant epigenetic remodeling represents a molecular hallmark in lung adenocarcinoma (LUAD). We aim to investigate the biological roles of SETDB2 and its underlying associations with oxidative stress, providing therapeutic targets for individualized treatment of LUAD.MethodsDifferential analysis was conducted via Limma package, and Kaplan–Meier analysis was performed with survival package. CCK‐8, cell proliferation assay, transwell assay, and in vivo assays were conducted to assess the function of SETDB2. Western blot assay, RT‐qPCR, and immunohistochemistry (IHC) were conducted to assess the expression levels of SETDB2/NRF2. Chromatin immunoprecipitation (ChIP) assay and ChIP‐qPCR were conducted to assess the epigenetic roles of SETDB2.ResultsWe found that SETDB2 expression is decreased in tumor samples versus normal tissues in TCGA‐LUAD cohort, LUAD‐EAS cohort, GSE72094 dataset, and independent Soochow‐LUAD dataset. Patients with low SETDB2 levels had a worse prognosis relative to those with high SETDB2. SETDB2 inhibition could significantly promote cell growth, migration ability, and stemness maintenance. Gene set enrichment analysis (GSEA) suggested that SETDB2 correlated with oxidative stress crosstalk and regulated NRF2 mRNA levels. ChIP assay suggested that SETDB2 mainly recruited the H3K9me3 enrichment at the NRF2 promoter region to suppress the mRNA levels of NRF2. Downregulated SETDB2 could activate NRF2 transcription and expression, thereby promoting its downstream targets, like NQO1, FTH1, and ME1. Functional experiments demonstrated that low SETDB2 allowed NRF2 to drive malignant processes of LUAD. SETDB2 overexpression attenuated the ability of NRF2 signaling to neutralize cellular reactive oxygen species (ROS) levels, leading to enhanced cell apoptosis. Overexpressed SETDB2 could inhibit tumor progression in vivo and further render LUAD cells sensitive to chemotherapy.ConclusionsIn conclusion, these findings uncovered the suppressive role of SETDB2 in LUAD. SETDB2 negatively regulates NRF2 signaling to modulate tumor progression, which creates a therapeutic vulnerability in LUAD.
Photoactive Hexaazaphenalene‐based Coordination Network as a Two‐Pathway Photosensitizer for Oxidation of Alkanes
Authors: Deekamwong Krittanun , Wada Yuki , Zhu Yiying , Usov Pavel M , Tagami Yu , Ohtsu Hiroyoshi , Kawano Masaki 
Published: December 2022

AbstractA tris(4‐pyridyl) hexaazaphenalenyl anion (TPHAP−) exhibited both energy and charge transfer processes to oxygen molecules under UV irradiation resulting in the production of reactive oxygen species (ROSs). The existence of ROSs was confirmed by spectroscopic characterization and photooxidation of a standard compound selective for the singlet oxygen, 1,5‐dihydroxynaphthalene (1,5‐DHN). In addition, a porous coordination network (PCN) consisting of TPHAP−, cadmium ions and fumarate co‐ligand was synthesized and used as a heterogeneous photosensitizer capable of ROSs generation. To take advantage of this ability, photooxidation of various saturated hydrocarbons including cyclohexane, cyclooctane and n‐octane was investigated. TPHAP‐based PCN demonstrated excellent photosensitizing ability achieving more than a hundred times higher turnover frequency than other reported coordination networks based on photoactive ligands.
Particle Residence Time Determination with More Than 400 Tracer Particles in a Circulating Fluidized‐Bed Full‐Loop System
Authors: Wu Erdong , Cheng Leming , Wei Yangjun , Ma Zhangke , Guo Qiang , Li Weicheng 
Published: December 2022

AbstractThe residence time of particles in a circulating fluidized‐bed (CFB) reactor is the essential parameter for design and performance of a CFB system. In this work, a noninvasive measurement method of positing tracer particles in a full‐loop CFB system is proposed. Based on the radio frequency identification technology, more than 400 tracer particles with individual code were made and moved freely in the CFB full loop system. With detecting the tracer particles' trajectory by high‐frequency readers located outside of the system, the effects of operating parameters including fluidization number and solid inventory on the movement and residence time of the tracer particles in the CFB system were investigated. The particle residence time is distributed in a certain range, influenced by superficial gas velocity and solid inventory.