bluuebunny/crossref_metadata_2025_split huggingface dataset:
US Hospital Stays in Children and Adolescents With Acetaminophen Poisoning
Authors: Shadman Kristin A. , Edmonson M. Bruce , Coller Ryan J. , Sklansky Daniel J. , Nacht Carrie L. , Zhao Qianqian , Kelly Michelle M. 
Published: January 2022

Abstract

OBJECTIVES
Acetaminophen poisoning occurs in all age groups; however, hospital-based outcomes of children with these poisonings were not well characterized. Our objectives were to describe the incidence, characteristics, and outcomes of hospital stays in children with acetaminophen poisoning and evaluate the contribution of intentionality.

METHODS
We used the 2016 Kids’ Inpatient Database and validated International Classification of Diseases, 10th Revision diagnostic codes to identify hospitalizations of children aged 0 to 19 years for acetaminophen poisoning. We used standard survey methods to generate weighted population estimates and describe characteristics and outcomes, both overall and stratified by intentionality.

RESULTS
There were 9935 (95% confidence interval [CI], 9252–10 619) discharges from acute care hospitals for acetaminophen poisoning in U.S. children aged 0 to 19 years during 2016, corresponding to a population rate of 12.1 (95% CI, 11.3–12.9) hospitalizations per 100 000 children. Most hospitalizations for both intentional and unintentional acetaminophen poisoning occurred in females, with a strongly age-related sex distribution. Median length of stay was 2 days (interquartile range, 1–4 days); however, nearly half of discharges were subsequently transferred to another type of facility (eg, psychiatric hospital). Median hospital charges for acute care were $14 379 (interquartile range, $9162–$23 114), totaling $204.7 million (95% CI, $187.4–$221.9) in aggregate. Of 31 632 hospital discharges associated with self-harm medication poisoning in children aged 0 to 19 years, acetaminophen was the single most commonly implicated agent.

CONCLUSIONS
Acetaminophen poisoning was the most common cause of U.S. hospital stays associated with medication self-harm poisoning. More effective acetaminophen poisoning prevention strategies are needed, which may reduce the burden of this common adolescent malady.
“GÊNERO” NOS PLANOS NACIONAIS DE EDUCAÇÃO (2001 E 2014): discursos antifeministas e inflexões nos processos decisórios
Authors: Moreno Meire Ellen , Mariano Silvana 
Published: January 2022

Os planos de educação, nacional, estaduais e municipais, foram importante objeto de disputa política em anos recentes no Brasil e terreno de forte atuação de movimentos e discursos antifeministas. Esta tem disso uma forma de reação à organização e aos resultados alcançados pelas lutas feministas, especificamente à emergência e usos do conceito de gênero na política internacional e nacional. O objetivo deste artigo é compreender as etapas da elaboração do Plano Nacional de Educação de 2014, identificando os momentos de inflexão do processo, e desvendar as rupturas e continuidades relativas às questões de gênero entre o PNE 2014-2024 e seu precedente, especificamente no que diz respeito às questões de gênero, sexualidade e orientação sexual. O estudo está baseado em revisão bibliográfica e pesquisa documental. Constatamos que os avanços nas discussões sobre políticas educacionais com perspectiva de gênero ocorreram nos momentos de participação da sociedade civil e dos movimentos sociais e que os principais momentos de inflexão ocorreram nas instâncias institucionais do poder político. Concluímos pela importância do fortalecimento da participação democrática para os avanços, ou conservação das conquistas, relativas às questões de gênero.
LoRaWAN ein Baustein für NOA
Authors: Manske Hartmut , Eder Renato , Ulmke Benedikt 
Published: January 2022

Das NAMUR-Open-Architecture-Konzept (NOA) beschreibt additive Strukturen, die an die klassische Automatisierungspyramide andocken und mittels deren Daten aus Produktionsanlagen zur Einspeisung in den digitalen Zwilling bereitgestellt werden können. Kann die Long Range Wide Area Technologie (LoRaWAN) in diesem Kontext eingesetzt werden? Der LoRaWAN Funkstandard dient primär der Erfassung einer hohen Zahl von Teilnehmern mit niedriger Datenrate in urbanen Strukturen. BeimPiloteinsatz im industriellen Umfeld in der Prozessindustrie zeigte sich, dass sich zahlreiche Anwendungsmöglichkeiten ergeben können.
Role of hyperthermic intraperitoneal chemotherapy in combination with an intraperitoneal port system in the treatment of patients with advanced ovarian cancer
Authors: Saevets V. V. , Privalov A. V. , Vazhenin A. V. , Shamanova A. Yu. , Mukhin A. A. , Taratonov A. V. , Semenov Yu.  A. , Shamaeva T.  N. 
Published: January 2022

Background. The survival rate of patients with ovarian malignancies depends on the prevalence of the tumor process, the volume of surgical treatment, and the size of the residual tumor. At the first stage, an «aggressive» surgical tactic of removing all macroscopically determined tumor foci with subsequent antitumor drug therapy is recommended. However, the results of treatment remain unsatisfactory, which dictates the need to search for new methods of treatment.Objective: to evaluate the effectiveness of implantable port systems for intraperitoneal chemotherapy administration in the treatment of patients with advanced stages of ovarian cancer.Materials and methods. 37 cases of stage IIIC ovarian cancer were studied for the period 2018–2019. At the first stage of treatment, a cytoreductive operation was performed. At the second stage, the patients were randomly randomized into three groups: group 1 (n = 9) – installation of a port system + hyperthermic intraperitoneal chemoperfusion followed by intraperitoneal chemotherapy; group 2 (n = 11) – hyperthermic intraperitoneal chemoperfusion followed by systemic intravenous chemotherapy; group 3 (n = 17) – control group, intravenous administration of antitumor drugs. The observation period is 27 months. In the study groups, the indicators of age distribution, the degree of malignancy of the neoplasm, the volume of the residual tumor, and the relapse-free survival were analyzed.Results. Trends towards differences in progression-free survival were found in all study groups. In group 1, there was no relapse in all patients. In group 2, relapses amounted to 18.2 %, in group 3–23.5 %. G3 ovarian cancer (6 (66.7 %) and 6 (54.5 %) cases, respectively) prevailed in groups 1 and 2; G1 ovarian cancer (9 (52.9 %) cases) prevailed in group 3. Discussion. Features of the chemical composition and method of administration of the drug increase the effectiveness of local exposure to tumor cells. The introduction of cytostatic agents into the abdominal cavity leads to minimal systemic toxicity, which exceeds the results of standard intravenous therapy.Conclusion. An advantage in the relapse-free survival of patients after hyperthermic intraperitoneal chemoperfusion in combination with an implantable port system was found in comparison with standard methods of treatment.
​Development of Foxtail Millet (Setaria italica) based Laddu
Authors: Sudha K.V. , Karakannavar Sarojani J. , Inamdar Basavraj , Yenagi Nirmala B. 
Published: January 2022

Background: Foxtail millet (Setaria italica) is the second-most widely planted species of millet. It is known for its health benefits. Laddu are ball-shaped sweets popular in the Indian Subcontinent. Laddus are made of flour, ghee and sugar with other ingredients that vary by recipe. They are often served at festive or religious occasions. Hence, an attempt was made to develop foxtail millet based value added laddu. Methods: Optimization of foxtail millet flour, ghee, sugar and roasting time was carried out. Sensory evaluation was done by nine point hedonic scale. Result: Standardization trials indicated that acceptable foxtail millet laddu could be developed by incorporating 50 per cent foxtail millet flour, 50 per cent bengal gram dhal flour, 45 per cent ghee, 75 per cent sugar powder and 40 minutes of roasting time in the standard laddu recipe. Physical and descriptive qualities of prepared laddus were also carried out. The nine-point hedonic scale was used for sensory evaluation. The developed foxtail millet laddu was highly accepted.
PEMANFAATAN AUGMENTED REALITY UNTUK MELATIH KETERAMPILAN BERPIKIR ABAD 21 DI PEMBELAJARAN IPA
Authors: Vari Yonatan , Bramastia Bramastia 
Published: January 2022

<p><em>Era Revolusi 4.0 ditandai dengan perkembangan internet dan teknologi digita</em><em>l. </em><em>Era</em><em> </em><em>Revolusi 4.0 diyakini akan berpengaruh terhadap perubahan pembelajaran Sains </em><em>yang mampu melatih keterampilan berpikir abad 21.</em><em> </em><em>Pembelajaran Abad 21 menekankan subjek pembelajaran terhadap siswa pada keterampilan dalam menggunakan Media, Informasi dan Teknologi; Keterampilan berpikir dan berinovasi. Augmented Reality merupakan inovasi teknologi yang sedang berkembang dan dimanfaatkan pada pembelajaran IPA oleh beberapa peneliti untuk melatih keterampilan Abad 21. Metode Penelitian merupakan penelitian studi literatur dengan menelaah sumber baik dari buku maupun jurnal terkait dengan Augmented Reality dan Keterampilan Abad 21Penelitian yang dilakukan beberapa peneliti saat ini yaitu memanfaatkan Augmented Reality untuk melatih keterampilan berpikir yang meliputi keterampilan berpikir kritis, keterampilan berpikir abstrak, dan kemampuan berpikir kreatif. Penelitian yang ada menemukan bahwa Augmented Reality dapat melatih keterampilan berpikir siswa pada pembelajaran IPA.</em></p>
Hubungan Status Gizi dan Prestasi Belajar
Authors: Cahyanto Erindra Budi , Mulyani Sri , Nugraheni Angesti , Sukamto Ika Sumiyarsi , Musfiroh Mujahidatul 
Published: January 2022

<p><strong>Latar belakang</strong></p><p>Gizi merupakan salah satu faktor penentu utama kualitas Sumber Daya Manusia. Pemberian gizi yang kurang baik terutama terhadap anak dan remaja, akan menurunkan potensi sumber daya pembangunan masyarakat. Banyak faktor yang mempengaruhi prestasi belajar. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara status gizi dengan prestasi belajar pada mahasiswa Diploma Kebidanan FK UNS tahun akademik 2018/2019. </p><p><strong>Metode </strong></p><p>Penelitian ini menggunakan desain <em>observasional analitik</em> dengan pendekatan <em>cross sectiona</em><em>l. </em>Populasi adalah mahasiswa prodi Sarjana Terapan Kebidanan FK UNS tahun akademik 2018/2019 yang hadir saat pengambilan data dan bersedia menjadi subjek penelitian. Data status gizi diperoleh melalui pengukuran indeks massa tubuh (BB/TB), prestasi belajar dari nilai indeks prestasi pada sistem informasi akademik. Skala data kategorik dianalisis menggunakan uji sommers'd<em> </em>dengan bantuan program SPSS 21.</p><p><strong>Hasil</strong></p><p>Pengukuran status gizi menunjukan terdapat tiga mahasiswa dengan kategori kurus, lima orang gemuk dan sembilan belas normal. Mayoritas subjek dalam derajat kriteria 4 dengan indek prestasi 3,31 – 3,70.</p><p><strong>Simpulan</strong></p><p>Terdapat hubungan signifikan antara status gizi dan prestasi belajar dengan arah korelasi positif. Mahasiswa hendaknya memperhatikan status gizi agar memperoleh prestasi yang semakin baik</p><p> </p>
Anterior Column Reconstruction with Vascularized Rib After Thoracic Spondylectomy
Authors: Tobert Daniel G. , Yeung Caleb M. , Morse Christopher R. , Lee Sang-Gil , Schwab Joseph H. 
Published: January 2022

Case:
A 35-year-old man with a chondrosarcoma of the thoracic spine was treated with neoadjuvant proton radiotherapy (RT), total en bloc spondylectomy (TES), and adjuvant RT. Multiple vertebrae were removed to ensure negative margins, which created a sizable midthoracic defect. A vascularized rib autograft was harvested and intussuscepted within a femoral allograft for reconstruction of the anterior column and supplemented with posterior and lateral instrumentation.

Conclusion:
This report demonstrates the feasibility of using a rib autograft within a femoral allograft sleeve to achieve immediate robust biomechanical support and eventual osseous union after thoracic TES for malignant tumors.
Neurophysiological Intraoperative Monitoring in Patients with Cochlear Implant Undergoing Posterior Spinal Fusion
Authors: Pan Tommy , Adeyemo Adeshina , Armstrong Douglas G. , Petfield Joseph L. 
Published: January 2022

Case:
Transcranial electric stimulation motor-evoked potentials (tcMEPs) are the most sensitive technique in multimodality intraoperative neuromonitoring (IONM) for posterior spinal fusion (PSF). The presence of a cochlear implant (CI) is considered a contraindication to IONM because of theoretical risk of implant device and local tissue damage from voltages induced by tcMEPs. We present the case of a 10-year-old girl with CI who underwent successful PSF with tcMEP and monopolar electrocautery (MoEC) without perioperative complications or CI damage.

Conclusion:
With proper precautions, such as MoEC usage at a minimal voltage, motor-evoked potential monitoring can be safely performed in pediatric patients with CI undergoing PSF.
The Efficacy and Safety of High-Dose Nonsedating Antihistamines in Chronic Spontaneous Urticaria: A Systematic Review of Randomized Clinical Trials
Authors: Xiao Xianjun , Shi Yunzhou , Yao Junpeng , Cao Wei , Zhang Leixiao , Zou Zihao , Zhou Siyuan , Wang Chuan , Chen Mingling , Jin Rongjiang , Li Ying , Zheng Qianhua 
Published: January 2022

Abstract
Background
Standard doses of second-generation H1-antihistamines (sgAHs) as first-line treatment are not always effective in treating chronic spontaneous urticaria (CSU), and hence an increase in the dose of sgAHs is recommended. However, literature evaluating the efଁcacy and safety of this treatment remains inconclusive, highlighting the need for a meta-analysis. The aim of this meta-analysis was to evaluate the efଁcacy and safety of high-dose sgAHs compared with standard-dose sgAHs in treating CSU.
Methods
A systematic literature search of double-blind, randomized controlled trials (RCT) utilizing multiple doses of sgAHs was performed by searching the electronic databases Medline, Embase, PsycINFO, Cochrane databases, and Web of Science. The response rate, the number of adverse events, somnolence, and withdrawal due to adverse events were extracted from each article. The data were combined and analyzed to quantify the safety and efficacy of the treatment.
Results
A total of 12 studies were identified, six of which met the eligibility criteria for the meta-analysis. Our pooled meta-analyses showed that high-dose sgAHs was associated with a significantly higher response rate than standard-dose (RR 1.12, 95% CI 1.01 to 1.24; P = 0.04). Conversely, high doses of sgAHs were associated with significantly higher somnolence rates than standard dose (RD 0.05, 95% CI 0.01 to 0.09; P = 0.02). There was no significant difference in adverse events or withdrawal due to adverse events between standard- and high-dose treatments.
Conclusions
Our analyses showed that a high dose of sgAHs (up to two times the standard dose) might be more effective than a standard dose in CSU treatment. High-dose and standard-dose sgAHs showed similar adverse events, except for somnolence, where incidence was found to be dose-dependent in some studies. However, given the limited number of studies, our meta-analysis results should be interpreted with caution.
Activating Unconventional Wavelength Bands for Coherent Optical Communication by On-chip Continuous Spectral Translation
Authors: Kong Deming , Liu Yong , Ren Zhengqi , Jung Yongmin , Kim Chanju , Chen Yong , Wheeler Natalie V. , Petrovich Marco N. , Pu Minhao , Yvind Kresten , Galili Michael , Oxenløwe Leif , Richardson David , Hu Hao 
Published: January 2022

Abstract
Despite being perceived historically to provide "unlimited" bandwidth, today’s optical communication systems are fast approaching their capacity limits in the conventional telecom bands. To satisfy the ever-increasing capacity demand, opening up new wavelength bands is becoming an appealing solution both in cabled and free-space optical communications in the transparent windows. However, this would ordinarily require the development of whole optical transceivers for any new wavelength band, which is both time-consuming and expensive. Here, we present an on-chip continuous spectral translation based coherent optical communication approach that can exploit existing commercial transceivers to unlock the vast and currently unused potential new wavelength bands rather than dictate the need to develop new coherent transceivers operating directly in those bands. The spectral translators are continuous-wave pumped aluminium gallium arsenide on insulator (AlGaAsOI) nanowaveguides that can provide a continuous conversion bandwidth over an octave. This enables unprecedented coherent transmission in the 2-μm wavelength band using well-developed conventional C-band transmitters and coherent receivers. We demonstrate 318.25-Gbit s-1 Nyquist wavelength-division multiplexed coherent transmission over a 1.15-km hollow-core fibre in the 2-μm wavelength band using this approach. Our demonstration paves the way for coherently transmitting, detecting, and processing signals at wavelength bands beyond the capability of today’s devices.
A Pharmacovigilance Study of the Association Between Tetracyclines and Hepatotoxicity Based on FDA Adverse Event Reporting System Data
Authors: Wei Chunyan , Liu Ying , Jiang Aidou , Wu Bin 
Published: January 2022

Abstract
Background Tetracyclines have been used in the clinic for decades. However, there is some controversy about the risk of tetracycline-associated hepatic injury. The aim of this pharmacovigilance study was to evaluate the association between drug-induced liver injury (DILI) and tetracyclines based on the FDA Adverse Event Reporting System (FAERS) database. Methods All reported cases of tetracyclines as primary suspected drugs were extracted from the FAERS between January 2004 and December 2020. The outcomes included all severe drug-related hepatic disorders, hepatocellular injury, cholestatic injury and liver failure. Disproportionality analyses are conducted by estimating both the reporting odds ratio (ROR) method and the information element (IC) method. Results A total of 1435 tetracycline-associated hepatic injury cases were identified in FAERS. Tigecycline, minocycline and doxycycline were found to be significantly associated with severe DILI, and the ROR, IC and their 95% CIs of tigecycline, minocycline and doxycycline were (ROR=5.85, 95% Cl 4.96~6.91, IC=2.44, 95% Cl 1.85~2.95), (ROR=6.40, 95% Cl 5.76~7.11, IC=2.56, 95% Cl 2.19~2.89) and (ROR=2.07, 95% Cl 1.86~2.31, IC=1.03, 95% Cl 0.66~1.38), respectively. Compared to minocycline and doxycycline, tigecycline showed a stronger association with hepatocellular injury (ROR=7.11, 95% Cl 6.13~8.23, IC= 2.68, 95% Cl 2.16~3.13) and cholestatic injury (ROR=12.16, 95% Cl 10.13~14.61, IC=3.51, 95% Cl 2.79~4.00). Tigecycline (ROR=6.56, 95% Cl 4.57~9.41, IC=2.69, 95% Cl 1.28~3.64) and minocycline (ROR=4.22, 95% Cl 3.14~5.66, IC=2.06, 95% Cl 1.00~2.93) showed a significant association with liver failure. Conclusion Based on current research, we discovered significant associations between DILI and tigecycline, minocycline and doxycycline. Tigecycline is more strongly correlated with hepatocellular injury and cholestatic injury than minocycline and doxycycline.
Risk Factors for Dose Reduction of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis: a Study Based on Real-world Clinical Data
Authors: Kim Jiwon , Chung Chiwook , Cho Hyo Sin , Kim Ho Cheol 
Published: January 2022

Abstract
Background Although pirfenidone slows disease progression in patients with idiopathic pulmonary fibrosis (IPF), patients often cannot tolerate the recommended dose of pirfenidone because of several adverse events in clinical practice. This study aimed to investigate adverse events associated with pirfenidone and the risk factors in patients requiring dose reduction.Methods This single center retrospective cohort study included 156 consecutive patients with IPF who received pirfenidone. Demographic characteristics, pulmonary function, and pirfenidone-related adverse events were investigated. We compared patients who received standard and reduced dose of pirfenidone.Results The mean age of patients was 69.7 years. The median follow-up duration was 243 days. The low dose group (n = 99) comprised older patients (71.0 vs. 67.4 years, p = 0.012), fewer smokers (79.8% vs. 96.4%, p = 0.004), and patients with lower body mass index (BMI; 24.2 vs. 25.7, p = 0.020) compared with the standard dose group (n = 57). Multivariate logistic regression analysis revealed that older age (odds ratio = 1.060, p = 0.014) was significantly associated with dose reduction of pirfenidone after adjusting for sex, smoking history, and BMI. No significant difference was found in the reduction rate of forced vital capacity (p = 0.260) and diffusing capacity for carbon monoxide (p = 0.186) between the standard and low dose groups.Conclusions Although older patients are more likely to undergo dose reduction of pirfenidone, low dose pirfenidone is effective for treating patients with IPF. Low dose pirfenidone can be considered an effective treatment option for older patients with IPF.
An Ethnobotany Survey of Wild Plants Used by the Tibetan People of the Yadong River Valley, Tibet, China
Authors: Guo Chang-An , Ding Xiao-Yong , A·D Yi-Won , Zhang Yu , Zhang Xiao-Qian , Zhuang Hui-Fu , Wang Yu-Hua 
Published: January 2022

Abstract
IntroductionPlant resources gathered from the wild are important sources of livelihood needs, especially for the low-income populations living living in remote areas, who rely on these plants for food, fuelwood, medicine and building materials. Yadong County is a valley on the border of the three countries in southern Tibet. Yadong is rich in biodiversity and culture, but ethnobotanical knowledge has not been systematically studied. The purpose of this research is: to document the ethnobotanical knowledge of the Tibetans in Yadong County.MethodsEthnobotanical data were documented through free listing, key informant interviews, and semistructured interviews during field work. The CI (cultural importance index) and FIC (informant consensus factor index) were used as quantitative indices.Results163 informants (46 women and 117 men) were interviewed. In total, 3031 use reports and 121 plant species belonging to 52 families and 91 genera were included. Then these use reports were classified into 20 categories belonging to the nine major categories. The utilization categories that contained the most plant species were food, followed by economic, medicine, animal food, social uses, other uses, environmental uses, materials and fuels. Among the economic plants, thirty-two kinds of medicinal plants are traditionally used in the local region for sale. The plants with high CI were Fritillaria cirrhosa, Neopicrorhiza scrophulariiflora, Betula utilis, Rheum nobile, Urtica hyperborean.ConclusionThis research demonstrates the diversity of types and functions of the Yadong Tibetan’s traditional plant knowledge. Knowledge of edible and medicinal plants in this area is more prominent, reflecting the ability to cope with the lack of fruits and vegetables and basic family medical care. There were exchanges between the traditional plant culture of the study area and the surroundings. With the socioeconomic development, the commercial value of medicinal plants has been developed, and locals are also seeking a path of sustainable development to cope with excessive consumption of plant resources.