bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study
Authors: Kennedy Megan , O’ Mahony Brian , Roche Sheila , McGowan Mark , Singleton Evelyn , Ryan Kevin , O’ Connell Niamh M. , Pipe Steven W. , Lavin Michelle , O’ Donnell James S. , Turecek Peter L. , Gormley John ,   on behalf of the iPATH study group
Published: March 2022

AbstractObjectivesTo establish the prevalence of pain and functional disability in Irish adults with moderate and severe haemophilia, and to examine demographic and lifestyle influences.MethodsMales ≥18 years with moderate or severe haemophilia participated. Pain and function were examined using the PROBE questionnaire.ResultsOf 49 participants [median age 44 (IQR 32, 52) years], most had severe haemophilia (Factor VIII = 30; Factor IX = 13) and were on regular prophylaxis (88%). Those with moderate haemophilia (Factor VIII = 5; Factor IX = 1) treated on demand (12%). Acute (72%) and chronic pain (71%), functional difficulties (58%), and analgesic requirements (92%) were prevalent. Age was significantly associated with more advanced haemophilic arthropathy (p = .002), chronic pain (p = .029) and functional difficulties (p = .036). Adults who reported chronic pain commenced prophylaxis significantly later in life [32 (20, 51) vs. 8 (1, 23) years; p = .004]. Physical activity was significantly lower in those with functional difficulties (p < .05). A disparity between self‐perceived ‘target joints’ and clinically defined target joints was also identified (76% vs. 23%).ConclusionHaemophilic arthropathy, pain and functional disability were prevalent amongst Irish adults with moderate and severe haemophilia. Age‐dependent lifestyle, analgesic and treatment influences on pain and function warrant further investigation.
What is the most effective treatment in horses with chorioptic mange?
Authors: Kondratjeva Jevgenija , Combarros Daniel , Pressanti Charline , Cadiergues Marie Christine 
Published: March 2022

SummaryChorioptic mange is a common pruritic skin disease in horses and can cause chronic pastern dermatitis. Many to all horses in one stable can suffer simultaneously and transmit the disease to one another through contact or by using the same areas. Treatment often is challenging, and failure and relapses are common. This paper reviews the evidence comparing different types of treatment of chorioptic mange in horses and found that although some protocols are partially effective, further comparisons are required.
Predictors of laminitis development in a cohort of nonlaminitic ponies
Authors: Knowles Edward J. , Elliott Jonathan , Harris Patricia A. , Chang Yu‐Mei , Menzies‐Gow Nicola J. 
Published: March 2022

AbstractBackgroundQuantifying risk factors for laminitis development requires improvement.ObjectivesTo identify the most useful physical examination, metabolic and management factors to predict laminitis development in client‐owned, nonlaminitic ponies.Study designProspective cohort study.MethodsPhysical examination, metabolic and management data were collected from a pony cohort 6 monthly for up to 4 years. Ponies were monitored for the development of laminitis. Metabolic data included basal plasma concentrations of ACTH ([ACTH]), adiponectin ([adiponectin]), triglycerides and glucose. Serum insulin concentrations ([insulin]) were measured in the unfasted basal state ([insulin]T0) and 60 minutes ([insulin]T60) after administration of corn syrup (0.3ml/kg). Separate multivariable Cox proportional‐hazards models were developed for physical, management/signalment and metabolic data and later combined into two final models. Low‐, medium‐ and high‐laminitis risk categories were defined based on basal or T60 [insulin].ResultsOverall, 374 ponies (age 5‐32 years) and 891 pony‐years were included in the main analysis. Laminitis incidence (95% confidence interval (CI)) was 4.8 (3.5‐6.5) cases/100 pony‐years. Laminitis development was associated with numerous univariable factors. Significant (P < .05) factors retained in the final multivariable models included [insulin]T0, [insulin]T60, [adiponectin] and divergent hoof growth. [ACTH] was not independently associated with laminitis. Based on [Insulin]T0, low‐ (<21.6 µIU/ml), medium‐ (21.6‐45.2 µIU/ml) and high‐risk (>45.2 µIU/ml) categories encompassed 70, 20 and 10% of the population and had estimated 4‐year laminitis incidences (95%CI) of 6 (2‐9)%, 22 (10‐33)% and 69 (48‐82)% respectively. Based on [Insulin]T60 the low‐ (<53.4 µIU/ml), medium‐ (53.4‐153 µIU/ml) and high‐risk (≥153 µIU/ml) categories comprised 60, 30 and 10% of the population and had estimated 4‐year laminitis incidences (95%CI) of 3 (0‐6)%, 20 (10‐29)% and 73 (52‐84)% respectively.Main limitationsResults may not apply to different insulin assays, geographical regions, breeds or management types.Conclusions[Insulin]T0 or [insulin]T60 best quantify the risk of future laminitis development in nonlaminitic ponies.
Exploring knowledge benchmarking using time‐series directional distance functions and bibliometrics
Authors: Nepomuceno Thyago Celso C. , de Carvalho Victor Diogho H. , Nepomuceno Késsia Thais C. , Costa Ana Paula C. S. 
Published: March 2022

AbstractFor strategic reasons, benchmarking best practices from efficient competitors is not usual in many data envelopment analysis (DEA) applications. Even for industries composed of multiple branches, providing information about efficient practices for their peers can jeopardize results for those branches if they compete for market, resources or recognition by the central administration. In this work, a time‐series adaptation for the DEA directional model is proposed as an alternative for coping with this problem. The methodological approach has three stages for this benchmarking to occur: Data, Information and Knowledge Extraction. In the first stage, we compare the same unit in different moments to identify efficient periods instead of efficient competitors. As a result, successful performance strategies are investigated using the bibliometric coupling of employees' relevant statements in the second and third stages. The application in a branch of the Brazilian Federal Savings Bank allowed an internal benchmarking of efficient periods when specific performance incentives, innovative processes, competitive strategies, and human resource changes were adopted for improving the unit's performance.
Reduced climate adaptation at range edges in North American Arabidopsis lyrata
Authors: Sánchez‐Castro Darío , Perrier Antoine , Willi Yvonne 
Published: March 2022

AbstractAimSpecies’ range limits, when not caused by dispersal limitation, are the result of constraints to the evolution of the ecological niche such that further range expansion is slow or not possible. An important evolutionary constraint at range edges may be the enhanced action of genetic drift. Here we tested whether a history of small population size and enhanced genetic drift was linked with reduced adaptation at range limits.LocationEastern North America.Time period2017–2019.TaxonArabidopsis lyrata subsp. lyrata.MethodsWe performed a latitudinal transplant experiment with sites across and beyond the species' distribution of North American Arabidopsis lyrata. Plants originated from the centre and the periphery, and the latter shared a history of range expansion or long‐term isolation and had low genetic diversity. We tested for adaptation by considering climatic variables that had previously been associated with both niche and range limits.ResultsMultiplicative performance of plants was lower the more different the temperature regime between a transplant site and a home site was, supporting climate adaptation. However, populations performed worse only when conditions were warmer at the transplant sites and better when conditions were colder, indicating that despite divergent adaptation to climate, the species seems to prefer living in cooler areas than where it is found currently. Finally, populations with low genetic diversity had a lower performance under a climate similar to that of their home sites, and performance declined more strongly under warmer conditions.Main conclusionsOur study provides evidence that genetic drift reduces adaptation at species’ range limits, and that populations with a history of genetic drift are especially vulnerable under global warming.
Luxury brand attachment: Predictors, moderators and consequences
Authors: Shimul Anwar Sadat , Phau Ian 
Published: March 2022

AbstractAlthough there is ample evidence that consumer attachment varies across luxury and non‐luxury brands, there is a lack of research in understanding the predictors, moderators and consequences of luxury brand attachment (LBA). This paper aims to develop and test a research model for LBA (study 1), examine the moderating influence of self‐consciousness on the relationship between actual/ideal self‐congruence and LBA (study 2) and validate the research model across privately and publicly consumed products (study 3). Data (n = 961) were analysed using Structural Equation Modelling with the IBM SPSS AMOS 25.0. The results show that consumers’ perceived actual and ideal self‐congruence have a significant positive impact on LBA. In addition, LBA results in consumer advocacy. Private (public) self‐consciousness enhances the relationship between actual (ideal) self‐congruence and LBA. However, social anxiety did not influence the relationship between self‐congruence and LBA. Moreover, the relationship between actual self‐congruence and LBA was stronger for privately consumed products. This research would provide luxury managers with an understanding of how consumers develop a bond with luxury brands based on the perceived brand self‐congruence. The LBA model would also help managers segment luxury consumers and identify the segments with low, medium and high attachment. In addition, using the findings of this research, luxury managers can incorporate the relevant aspect of self‐congruence into brand positioning and advertising messages.
Suboptimal COVID‐19 vaccine uptake among hospitalised patients: an opportunity to improve vulnerable, hard‐to‐reach population vaccine rates
Authors: Roberts Matthew B. , Ferguson Catherine , McCartney Erin , Selvanderan Kendra , Badiei Arash , Paradiso Lisa , Wallace Caitlin , Torpy Helena , Zhang Frank , Sim Beatrice , Papanicolas Lito , Ashokan Anushia , Shaw David , Bak Narin 
Published: March 2022

AbstractBackgroundCOVID‐19 vaccination represents a key preventative part of the Australian public health approach to the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic. Hospital inpatients are frequently high risk for severe COVID‐19 and death. Anecdotes of high‐risk inpatients being unvaccinated and a lack of electronic medical record (EMR) visibility of COVID‐19 vaccination status prompted the present study as these patients could represent a risk to themselves, staff, other patients and service provision.AimsTo determine the uptake of COVID‐19 vaccine among inpatients at an adult Australian tertiary public hospital and identify reasons for non‐vaccination.MethodsA point‐prevalence study of patient‐reported COVID‐19 vaccine status was conducted on 26 October 2021 through an in‐person interview with collection of demographic factors and reasons for non‐vaccination.ResultsOf 368 (68% of inpatients) participants, 280 (76%) reported receiving at least one COVID‐19 vaccine dose. Vaccination status was associated with older age, having received the flu vaccine, being born in Australia and not requiring an English‐language interpreter. The majority (88%) of participants had at least one comorbid risk factor for severe COVID‐19. Of the unvaccinated (n = 88), 67% were willing to be vaccinated with 54% of those indicating vaccination in hospital would be helpful and 42% requesting approval from their doctor.ConclusionsVaccine uptake in our cohort is suboptimal. Existing public health programmes have failed to reach this high‐risk, vulnerable population. Changes to the national vaccination strategy to include a parallel inhospital programme for all hospital encounters and target culturally and linguistically diverse individuals might improve uptake among this high‐risk, hard‐to‐reach group of patients.
CTLA4Ig/VISTAIg combination therapy selectively induces CD4+ T cell‐mediated immune tolerance by targeting the SOCS1 signaling pathway in porcine islet xenotransplantation
Authors: Wang Dan , Bai Xue , Wang Bin , Yi Qiying , Yu Weihua , Zhang Xinying , Tian Ruoyuan , Zhang Xiao , Li Caihua , Chen Yi , Liu Yang , Cheng Yao , He Sirong 
Published: March 2022

AbstractT cell inhibitory receptors can regulate the proliferation or function of T cells by binding to their ligands and present a unique opportunity to manage destructive immune responses during porcine islet xenotransplantation. We applied ex vivo porcine islet xenotransplantation and in vitro mixed lymphocyte‐islet reaction models to assess immune checkpoint receptor expression profiles in recipient T cells, investigated whether CTLA4 or VISTA immunoglobulin (Ig) combination therapy alone could suppress porcine islet xenograft rejection and further analyzed its potential immune tolerance mechanism. Recipient T cells expressed moderate to high levels of CTLA4, PD‐1, TIGIT and VISTA, and the frequency of CTLA4+CD4+, TIGIT+CD4+, VISTA+CD4+ and VISTA+CD8+ T cells was positively correlated with porcine islet xenograft survival time in xenotransplant recipients. Combined treatment with CTLA4Ig and VISTAIg selectively inhibited recipient CD4+ T cell hyper‐responsiveness and proinflammatory cytokine production and significantly delayed xenograft rejection. SOCS1 deficiency in CD4+ T cells stimulated by xenogeneic islets facilitated hyper‐responsiveness and abolished the suppressive effect of combination therapy on recipient T cell‐mediated porcine islet damage in vivo and in vitro. Further mechanistic studies revealed that combined treatment significantly induced SOCS1 expression and inhibited the Jak‐STAT signalling pathway in wild‐type recipient CD4+ T cells stimulated by xenogeneic islets, whereas SOCS1 deficiency resulted in Jak‐STAT signalling pathway activation in recipient CD4+ T cells. We demonstrated a major role for CTLA4 and VISTA as key targets in CD4+ T cell hyper‐responsiveness and porcine islet xenograft rejection. The selective inhibition of CD4+ T cell immunity by CTLA4Ig/VISTAIg is based on SOCS1‐dependent signalling.
When do workers support executive aggrandizement? Lessons from the recent Turkish experience
Authors: Apaydin Fulya , Öngel Ferit Serkan , Schmid Jonas W. , Ülker Erol 
Published: March 2022

AbstractFollowing the 2017 constitutional referendum under the Adalet ve Kalkinma Partisi (Justice and Development Party‐AKP) rule in Turkey, the reforms granted judicial and legislative powers to the head of the executive under a presidential system. Initial observations reveal that some blue‐collar workers who are members of a historically progressive union have also supported these reforms. This is surprising because the union leadership has publicly opposed these changes. What explains this discrepancy? Why did some of these workers support reforms in favour of a powerful executive? Based on a sample from a major metalworking union, this paper finds that partisan identity moderates support for AKP's push for challenging the separation of powers. Although we find that higher amount of debt may reduce worker support for stronger executive, this is conditional on the metal workers' pre‐existing partisan commitments. Under these circumstances, highly indebted partisan workers do not diverge from the party line. These results also raise further questions for students of labour and regime change elsewhere in the developing world.
Quietly bearing the brunt of austerity in school: A qualitative study into children's experiences of food insecurity in Ghana
Authors: Mohammed Abdul‐Rahim 
Published: March 2022

AbstractThe dominant food security literature that reports on children's experiences of food insecurity rely on adult/parent proxies. Nevertheless, studies have shown that adult narrations of children's experiences might not always accurately reflect children's experiences. Furthermore, other studies have also shown that in many cases, children are the best reporters of their experiences. Against this background, this paper sets out to explore, from school children's own perspectives, their lived experiences of food insecurity in school under the Ghana School Feeding Programme (GSFP). This research is important because the latest round of austerity programmes in Ghana has compelled the service providers of the GSFP to resort to several coping strategies (such as rationing services, compromising the quality and quantity of meals served, and occasionally skipping service delivery) which can have significant effects on children's nutrition. Findings from group discussions and one‐on‐one semi‐structured interviews with 21 primary school children aged 8 to 15 highlight school children's experiences of food insecurity. By exploring children's experiences of food insecurity in school, this paper presents evidence that shows that research about children's experiences can and should be based on children's accounts and not adult proxies.
Settler Colonialism, Decolonization, and Climate Change
Authors: Reibold Kerstin 
Published: March 2022

ABSTRACTThe article proposes that climate change makes enduring colonial injustices and structures visible. It focuses on the imposition and dominance of colonial concepts of land and self‐determination on Indigenous peoples in settler states. It argues that if the dominance of these colonial frameworks remains unaddressed, the progressing climate change will worsen other colonial injustices, too. Specifically, Indigenous self‐determination capabilities will be increasingly undermined, and Indigenous peoples will experience the loss of what they understand as relevant land from within their own ontologies of land. The article holds that even if settler states strive to repair colonial injustices, these efforts will be unsuccessful if climate change occurs and decolonization is pursued within the framework of a settler colonial ontology of land. Therefore, the article suggests, decolonization of the ontologies of land and concepts of self‐determination is a precondition for a just response to climate change.
Strategies for repeat ablation for atrial fibrillation: A multicentre comparison of nonpulmonary vein versus pulmonary vein target ablation
Authors: Mol Daniel , Mulder Mark J. , Veenstra Rob , Allaart Cornelis P. , Hof Irene E. , Kemme Michiel J. B. , Khan Muchtiar , Kimman Geert‐Jan P. , Mairuhu Gideon , de Ruiter Gijsbert S. , Tahapary Giovanni J. M. , de Groot Joris R. , de Jong Jonas S. S. G. 
Published: March 2022

AbstractIntroductionApproximately 18% of patients with atrial fibrillation (AF) undergo a repeat ablation within 12 months after their index ablation. Despite the high prevalence, comparative studies on nonpulmonary vein (PV) target strategies in repeat AF ablation are scarce. Here, we describe 12 months efficacy of non‐PV and PV target ablations as a repeat ablation strategy.MethodsA multicentre retrospective, descriptive study was conducted with data of 280 patients who underwent repeat AF ablation. The ablation strategy for repeat ablation was at the operators' discretion. Non‐PV target ablation (n = 140) included PV reisolation, posterior wall isolation, mitral line, roofline, and/or complex fractionated atrial electrogram ablation. PV target ablation (n = 140), included reisolation and/or wide atrium circumferential ablation. Patients' demographics and rhythm outcomes during 12 months follow‐up were analyzed.ResultsAt 12 months, more atrial tachyarrhythmias were observed in the non‐PV target group (48.6%) compared to the PV target group (29.3%, p = .001). Similarly, a significantly higher AF and atrial tachycardia (AT) recurrence rate was observed after non‐PV target ablation compared to PV target ablation (36.4% vs. 22.1% and 22.9% vs. 10.7%). After adjustment, a significantly higher risk of AT recurrence remained in the non‐PV target group. Both groups significantly de‐escalated antiarrhythmic drug use; de‐escalation was more profound after PV target ablation. Patients with isolated PVs during non‐PV target ablation had a significantly higher risk for AF recurrence than those with reconnected PVs.ConclusionCompared to PV target ablation, non‐PV target repeat ablation did not improve outcomes after 12 months and was independently associated with an increased risk for AT recurrences.
Efficacy of autogenous tooth roots for a combined vertical and horizontal alveolar ridge augmentation and staged implant placement. A prospective controlled clinical study
Authors: Schwarz Frank , Obreja Karina , Mayer Stephanie , Ramanauskaite Ausra , Sader Robert , Parvini Puria 
Published: March 2022

AbstractObjectivesTo assess and compare the efficacy and safety of autogenous tooth roots (TRs) and autogenous bone blocks (ABs) for combined vertical and horizontal alveolar ridge augmentation and two‐stage implant placement.Materials and MethodsA total of 28 patients in need of implant therapy and vertical ridge augmentation were allocated to parallel groups receiving either healthy autogenous tooth roots (e.g., retained wisdom teeth) (n = 14,n = 15 defects) or cortical autogenous bone blocks harvested from the retromolar area (n = 14,n = 17 defects). After 26 weeks of submerged healing, the clinical reduction in ridge height (RH) deficiency was defined as the primary outcome.ResultsBoth surgical procedures were associated with a similar mean reduction in RH deficiency values, amounting to 4.48 ± 2.42 mm (median: 4.25; 95% CI: 3.08–5.88) in the TR group and 4.46 ± 3.31 mm (median: 3.00; 95% CI: 2.54–6.38) in the AB group (p = .60, Mann–WhitneyU‐test). In all patients investigated, the reduction in RH deficiency values allowed for an adequate implant placement at the respective sites. The frequency of complications (e.g., soft tissue dehiscences) was low (TR:n = 4; AB:n = 0).ConclusionsUp to staged‐implant placement, both TR and AB grafts appeared to be associated with comparable efficacy and safety for combined vertical and horizontal alveolar ridge augmentation.
A Money‐Financed Fiscal Stimulus: Redistribution and Social Welfare
Authors: PUNZO CHIARA , ROSSI LORENZA 
Published: March 2022

AbstractWe analyze the redistribution channel of a money‐financed fiscal stimulus (MFFS) versus debt‐financed fiscal stimulus (DFFS) in a Borrower–Saver framework. The redistribution channel is larger when we consider an MFFS and borrowers are the main beneficiaries. A liquidity trap scenario amplifies the differences between an MFFS and a DFFS. The redistribution channel makes an MFFS effective at having an expansionary effect in the medium run, despite the adverse scenario. We show, however, that an MFFS increases the consumption gap between the two agents by redistributing income from savers to borrowers. Thus, an MFFS results detrimental for welfare when the welfare function is approximated around the efficient steady state.