bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein is unsuitable as a diagnostic marker of occulthepatocellular carcinoma in end-stage liver cirrhosis
Authors: Nagakawa Kantoku , Hidaka Masaaki , Hara Takanobu , Matsushima Hajime , Imamura Hajime , Tanaka Takayuki , Adachi Tomohiko , Soyama Akihiko , Kanetaka Kengo , Eguchi Susumu 
Published: April 2022

Abstract
Background and Purpose: Serum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) is a marker of liver fibrosis and hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the diagnostic ability of WFA+-M2BP for occult HCC, which current diagnostic imaging tests fail to detect. Methods: Patients who underwent hepatectomy for liver transplantation (LT) and whose whole liver could be sliced and subjected to histological examination between 2000 and 2018 were eligible for this study (n = 89). WFA+-M2BP levels were measured in samples collected before the LT. Comparison of the postoperative histological test results with the preoperative imaging data grouped the patients into no group (N), detected group (D), increased group (I), and decreased or same group (DS), and the results were compared with the WFA+-M2BP values.Results: Irrespective of underlying hepatic disease conditions, there were 6 patients in the N group, 10 in the D group, 41 in the I group, and 32 in the DS group. The median of the serum WFA+-M2BP level for each group was as follows: N group, 8.05 (1.25–11.9); D group, 11.025 (1.01–18.21); I group, 9.67 (0.29–17.83); and DS group, 9.56 (0.28–19.44) confidence of interval. We found no significant differences between the pairings. Comparison of underlying hepatic diseases revealed that liver cirrhosis due to hepatitis B and C and non-B and -C liver cirrhosis had no significant differences. Conclusion: Serum WFA+-M2BP cannot help diagnose occult HCC that is already undetected using imaging tests in decompensated liver cirrhosis patients requiring LT.
Triassic closure of South Tianshan Ocean: Evidence from provenance analysis of High-Pressure relics-bearing fore-arc sediments and multi-disciplinary data
Authors: tan zhou , Xiao Wenjiao , Mao Qigui , Wang Hao , Sang Miao , Li Rui , Gao Limin , Guo Yuhong , Gan Jingmin , Liu Yanhong , Wan Bo 
Published: April 2022

Abstract
A major debate concerning the final welding time of southern Altaids has led to considerable uncertainty regarding the configuration of northeast Pangea and the reconstruction of proto-Asia. Here we report Triassic provenance deposited in a fore-arc accretionary basin closely located with the Akeyazi LT-UHP metamorphic complex in the South Tianshan Orogenic Belt (STOB). Field-based detrital zircon U-Pb analysis of sandstones yield a maximum depositional age of the early Triassic (~ 231.7 ± 1.1 Ma) with a major early Permian peak and few Precambrian records. Hf isotopic analysis, accompanying with multi-disciplinary data compilation, indicate the early Triassic sediment received additional detritus from distal juvenile East Tianshan Arc region, rather than from any proximate tectonic units or a missed intra-oceanic arc. A hypothesis is proposed for STOB geodynamic model with introducing temporary flat subduction beneath the Central Tianshan Arc region. Available data advocates the STO, which serves as an accessory ocean basin paleo-geographically belonging to the Paleo-Asian Ocean, may have been closed in the early Triassic.
Communications with Guaranteed Low Latency and Bandwidth
using Frequency Referenced Multiplexing
Authors: Zhou Zichuan , Wei Jinlong , Luo Yuan , Clark Kari , Sillekens Eric , Deakin Callum , Sohanpal Ronit , Slavík Radan , Liu Zhixin 
Published: April 2022

Abstract
The rise of timing-critical applications such as virtual reality and connected car fleets, combined with the rapid growth of the number of user devices, creates new challenges for the latency and reliability of user-cloud data communications. Currently user-cloud communications rely on time-scheduled data frames through tree-topology fibre networks, incapable of assuring guaranteed connections with low or stable latency, which is necessary for, e.g. remote surgeries and safe operations of self-driven cars. Besides, their scalability to a larger user count is limited. Here we show that clock and optical frequency synchronisation, enabled by burgeoning frequency comb and signal processing techniques, can provide each user with dedicated optical bandwidth to enable scalable user-cloud communications that guarantee simultaneously high per-user data rate and low latency. Our approach provides accurate clock and optical frequency synchronisation over deployed optical fibre links, which will be beneficial for many applications including accurate navigation, quantum communications, and astronomy.
Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS
Authors: Nabi Ivan Robert , Alan Parsa , Vandevoorde Kurt R. , Joshi Bharat , Cardoen Ben , Gao Guang , Mohammadzadeh Yahya , Hamarneh Ghassan 
Published: April 2022

Abstract
Mitochondria are major sources of cytotoxic reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, that when uncontrolled contribute to cancer progression. Maintaining a finely tuned, healthy mitochondrial population is essential for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria by autophagy, monitors and maintains mitochondrial health and integrity, eliminating damaged ROS-producing mitochondria. However, mechanisms underlying mitophagic control of mitochondrial homeostasis under basal conditions remain poorly understood. E3 ubiquitin ligase Gp78 is an endoplasmic reticulum membrane protein that induces mitochondrial fission and mitophagy of depolarized mitochondria. Here, we report that CRISPR/Cas9 knockout of Gp78 in HT-1080 fibrosarcoma cells increased mitochondrial volume, elevated ROS production and rendered cells resistant to carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitophagy. These effects were phenocopied by knockdown of the essential autophagy protein ATG5 in wild-type HT-1080 cells. Use of the mito-Keima mitophagy probe confirmed that Gp78 promoted both basal and damage-induced mitophagy. Application of a spot detection algorithm (SPECHT) to GFP-mRFP tandem fluorescent-tagged LC3 (tfLC3)-positive autophagosomes reported elevated autophagosomal maturation in wild-type HT-1080 cells relative to Gp78 knockout cells, predominantly in proximity to mitochondria. Mitophagy inhibition by either Gp78 knockout or ATG5 knockdown reduced mitochondrial potential and increased mitochondrial ROS. Live cell analysis of tfLC3 in HT-1080 cells showed the preferential association of autophagosomes with mitochondria of reduced potential. Basal Gp78-dependent mitophagic flux is therefore selectively associated with reduced potential mitochondria promoting maintenance of a healthy mitochondrial population and limiting ROS production.
In-memory sparse matrix multiplication with a low-power self-rectifying memristor array
Authors: Li Jiangcong , Ren Shengguang , Li Yi , Yang Ling , Yu Yingjie , Ni Run , Zhou Houji , Bao Han , He Yuhui , Chen Jia , Jia Han , Miao Xiang Shui 
Published: April 2022

Abstract
Memristor-enabled in-memory computing provides an unconventional computing paradigm to surpass the energy efficiency of von Neumann computers. However, owing to the physical limitation of the crossbar structure, although the memristor array is desirable for dense computation, it suffers from significant performance degradation in both energy and area efficiency when processing sparse linear algebra operations. In this work, we report a highly efficient in-memory sparse computing system based on the self-rectifying memristor, which originates from the joint effort of devices and algorithms and is used to solve computational modelling problems. This system is expected to have 74.9 – 19.6 TOPS / W energy efficiency for 2-bit to 8-bit sparse computation in computational modelling tasks. Compared to the previous in-memory computing hardware, our system provides over one order of magnitude improvement in energy efficiency with more than two orders of magnitude reduction in hardware overhead. This work could pave the road towards a highly efficient, unconventional computing solution for high-performance computing.
Peritumoral brain edema in relation to tumor size is a variable that influences the risk of recurrence in intracranial meningiomas
Authors: Frati Alessandro , Armocida Daniele , Arcidiacono Umberto A , Pesce Alessandro , D'Andrea Giancarlo , Cofano Fabio , Garbossa Diego , Santoro Antonio 
Published: April 2022

Abstract
Background
Peritumoral brain edema (PBE) is common in intracranial meningiomas (IM) and can increase its morbidity. It is not uncommon for a neurosurgeon to face the diagnosis of a meningioma with a large proportion of PBE irrespective of the site and size of the contrast-enhancing lesion without any clinical and biological cause.
Methods
We performed a retrospective review of 216 surgically-treated patients with IM. We recorded clinical, biological, and radiological data. Based on the rate of tumor and edema volume, we divided the patients into a group with high-ratio Edema/Tumor and a group with a low ratio. We investigated how the ratio of edema/lesion may affect the outcome.
Results
Multivariate analysis was performed for the two groups. Smokers were more frequently associated with the high-rate group. The edema/tumor ratio does not influence surgical radicality, however, independently of the biological subtype, WHO grading, and EOR, a higher frequency of recurrence is shown in patients with a high edema/tumor ratio (70.5% versus 8.4%. p < 0.01).
Conclusions
The relationship between tumor and edema volume is respected in our series, but it does not explain why there are so many cases in which the ratio is so high. It seems that the blood-brain barrier (BBB) damage from smoke could have a role in an increased volume of PBE.
Point matching based on affine invariant centroid tree for synthetic aperture radar image
Authors: Yan Xingwei , Wang Wei , Shi Jianhua , Liu Jin 
Published: April 2022

Abstract
Point matching has attracted important attention in radar signal processing while the targets can be modeled by point sets to realize their recognition. Due to the different imaging parameters or viewpoints, the images captured by different synthetic aperture radar (SAR) sensors suffer from distortions. Since the distortions between images can be approximated by affine transformations, the key problem for point matching is to extract affine invariant descriptors. Moment, which has been widely used for point matching, limits to affine transformations as their support point set (SPS) can’t keep invariant. To address this problem, AICT is proposed as a rigorous affine invariant SPS. It is constructed by a recursive process: the point set is first divided by the vector from the certain point to the centroid of the point set, and the centroids of subsets are used to generate vectors which induce new partitioning. In addition, the centroids of the subsets are stored in order to form the AICT of the point. AICT, which represents the inherent structure of the point set, highly tolerant to noise and outliers due to the global nature of our partitioning process. More importantly, it is affine invariant owing to the affine invariance of centroids and relative position. Therefore, we can get a new rigorous affine invariant descriptor while moments are computed based on the points in AICT. The experimental results on synthesized and real data validate verify that our proposed algorithm outperforms the state-of-the-art point matching methods including SC, ICP, and TPS-RPM.
Detailing Cloud Property Feedbacks with a Regime-Based Decomposition
Authors: Zelinka Mark , Tan Ivy , Oreopoulos Lazaros , Tselioudis George 
Published: April 2022

Abstract
Diagnosing the root causes of cloud feedback in climate models and reasons for inter-model disagreement is a necessary first step in understanding their wide variation in climate sensitivities. Here we bring together two analysis techniques that illuminate complementary aspects of cloud feedback. The first quantifies feedbacks from changes in cloud amount, altitude, and optical depth, while the second separates feedbacks due to cloud property changes within specific cloud regimes from those due to regime occurrence frequency changes. We find that in the global mean, shortwave cloud feedback averaged across ten models comes solely from a positive within-regime cloud amount feedback countered slightly by a negative within-regime optical depth feedback. These within-regime feedbacks are highly uniform: In nearly all regimes, locations, and models, cloud amount decreases and cloud albedo increases with warming. In contrast, between-regime components vary widely across models but are very small on average. This component, however, is dominant in setting the geographic structure of the shortwave cloud feedback: Thicker, more extensive cloud types increase at the expense of thinner, less extensive cloud types in the extratropics, and vice versa at low latitudes. The prominent negative extratropical optical depth feedback has contributions from both within- and between-regime components, suggesting that thermodynamic processes affecting cloud properties as well as dynamical processes that favor thicker cloud regimes are important. The feedback breakdown presented herein may provide additional targets for observational constraints by isolating cloud property feedbacks within specific regimes without the obfuscating effects of changing dynamics that may differ across timescales.
An investigation of insulin resistance and cachexia in patients with metastatic upper GI malignancies
Authors: Farashi Ebrahim , Mahmoodpour Ahmad , Akbari Aliakbar Movassaghpour , Sanaat Zohreh , Sarbakhsh Parvin , Chavoshi Seyed Hadi , Valizadeh Parya , Ghaffary Saba 
Published: April 2022

Abstract
IntroductionInsulin resistance has been suggested as one of the known metabolic disorders during cachexia. This study hypothesized that cachexia in cancer patients might be due to insulin resistance as early as cachexia development. MethodThis study was performed on 46 patients with metastatic gastrointestinal cancer. Anthropometric characteristics and biochemical markers were assessed at baseline, second month, and third month. Insulin resistance was assessed using the HOMA IR method. SFQ-36 questions were used to assess the patients' quality of life at baseline, second and third months.ResultsPatients' anthropometric characteristic was significantly associated between pre-cachectic and non-pre-cachectic patients in the third month. Cholesterol (P-value: 0.93), albumin (P-value: 0.82), and serum creatinine (P-value: 0.88) in pre-cachectic patients decreased over three months. There was an increasing trend of insulin resistance between pre-cachectic and non-pre-cachectic patients in the third month. Cholesterol had an upward trend with a significant relation in cachectic patients [(P-value: 0.00), (P-value: 0.03), (P-value: 0.01)]. We detected a decreasing trend of insulin resistance between cachectic and non-cachectic patients from the second to the third month (Pvalue= 0.04). SFQ evaluation had no significant relation with cachectic status.ConclusionSignificant relation between anthropometric variables with pre-cachexia and cachectic conditions was concluded. Patients' outcome and its relation with insulin resistance (age of 30≤, and above 30≥) demonstrated a significant relation between the cachectic and non-cachectic patients in the third month. We also detected the increased serum cholesterol level in cachectic patients, moreover, higher cholesterol levels in expired cachectic patients than in the living.
Synthesis, Characterization, Dielectric and Magnetic Properties of Substituted Y-Type Hexaferrites
Authors: Batool Syeda Rabia , Aman Salma , Aftab Faryal , Waheed Muhammad Suleman , Malana Muhammad Aslam , Gouadria Soumaya , Ashiq Muhammad Naeem 
Published: April 2022

Abstract
A series Manganese and Gadolinium doped Zinc-Strontium hexaferrites, Sr2Zn2 − xMnxFe12− Sr2Zn2 − xMnxFe12−yGdyO22 (x = 0.0–1.0, y = 0.0-0.1), was fabricated by chemical co-precipitation route. XRD analysis confirmed the single magnetoplumbite phase formed in hexaferrites with average crystallite size in the range 27–38 nm. Surface morphology and size distribution was also explored using Scanning electron microscopy (SEM). The dielectric parameters i.e. dielectric constant, dielectric loss and dielectic tan loss were measured at ambient temperature and in 1.0 MHz to 3.0 GHz frequency range. Mn-Gd substituted Zn-Sr hexaferrites showed independent trend of dielectric parameters with frequency upto a certain value beyond which resonance type behavior was observed. The dielectric parameters initially decrease with frequency then become almost constant followed by resonance type behavior. Subsitution of Mn and Gd resulted in sharp decrease of dielectric parameters followed by gradual increase. Due to doping to Mn and Gd, saturation magnetization (Ms) and Remenance (Mr) is enhanced whereas the coercivity has been decreased. The squareness ratio of synthesized nanoferrites is less than 0.5.
hUMSCs transplantation regulates AMPK/NR4A1 signaling axis to inhibit ovarian fibrosis in POI rats
Authors: Cui Linlu , Jiang Zhonglin , Zhu Wenqian , Tang Yu , Luo Qianqian , Si Yaru , Fu Qiang , Zhang Hongqin 
Published: April 2022

Abstract
Background
The mechanism of human Umbilical Cord Mesenchymal Stem Cells (hUMSCs) transplantation to improve ovarian function in the rats with Premature Ovarian Insufficiency (POI) is still unclear. The aim of this study is to investigate the signal axis mechanism that is involved in the ovarian function recovery of POI rats following hUMSCs transplantation.
Methods
The rat model with POI was established by intraperitoneal injection of cisplatin. The hUMSCs were transplanted by caudal vein injection into POI rats. Hematoxylin-eosin (H&E) staining was performed to examine the morphology of rat ovarian tissue. Masson staining, Sirus red staining and immunofluorescence were used to observe the fibrosis extent of ovarian tissue. The levels of serum sex hormones and the expression of fibrosis related markers in ovarian tissues were measured by enzyme-linked immunosorbent assay (ELISA). The expression of NR4A1, Phospho-NR4A1 and AMP-activated protein kinase (AMPK) signaling in rat ovarian tissues was measured by immunohistochemistry and immunofluorescence. The role of AMPK/NR4A1 signaling axis in the regulation of ovarian function recovery in POI rats following hUMSCs transplantation was further investigated by adenovirus and siRNA intervention in isolated stromal cells.
Results
The results showed that the hUMSCs transplantation significantly inhibited ovarian tissue fibrosis and restored the ovarian function in POI rats. The level of NR4A1 and AMPK expression in ovarian tissue of POI rats after hUMSCs transplantation was significantly increased compared with the control group. In the cultured ovarian stromal cells, the similar results were obtained on the expression of NR4A1 and its regulation on fibrosis related molecular markers in Cisplatin (CDDP) damaged stromal cells following hUMSCs supernatant treatment. Both hUMSCs supernatant treatment and the addition of AMPK inhibitors increased NR4A1 expression in stromal cells. And after NR4A1 molecular intervention, fibrosis-related indicators in stromal cells changed. The data suggests that the AMPK/NR4A1 signaling axis is involved in the ovarian function changes in POI rats following hUMSCs transplantation.
Conclusion
The data from this study indicate that the inhibition of tissue fibrosis and recovery of ovarian function is regulated by AMPK/NR4A1 signaling axis in POI rats following hUMSCs transplantation.
A highly selective fluorescent probe for the detection of nitroreductase based on a naphthalimide scaffold
Authors: Li Han , jintao Feng , Wang Zhen , Jia Yan , Li Peng , Yao Cuixia , Qu Zongjin 
Published: April 2022

Abstract
The development of fluorescent probes for nitroreductase (NTR) has received intense attention because of its biological significance and wide aplications. In this work, a novel fluorescent probe (MNI-NTR) based on a nitrobenzene switch for the detection of NTR in aqueous solution has been designed and synthesized on a 1,8-naphthalimide scaffold. The probe exhibited a high selectivity for NTR over various analyes with a detection limit of 9.8 ng/ml, especially without the interference from hydrogen sulfide. With the presence of NTR and NADH, MNI-NTR is converted into a 4-hydroxy-1,8-naphthalimide derivative under physiological conditions, showing a strong fluorescence peak at 550 nm. Theoretical calculations reveal that the reason for the fluorescence quenching of MNI-NTR is the photoinduced electron transfer (PET) from the nitrobenzene and morpholine groups to the naphthalimide fluorophore.
IsoQuant: a tool for accurate novel isoform discovery with long reads
Authors: Prjibelski Andrey , Mikheenko Alla , Joglekar Anoushka , Smetanin Alexander , Jarroux Julien , Lapidus Alla , Tilgner Hagen 
Published: April 2022

Abstract
Long reads are reshaping RNA biology. However, determining alternative isoforms from long-read RNA data is a complex and incompletely solved problem even when the reference genome is known. Here we present IsoQuant - a reference-based tool that accurately discovers novel transcripts with at least 3-fold lower false positive rate and 1.8-fold increase in F1-score compared to other tools for Oxford Nanopore data. IsoQuant also increases performance for Pacific Biosciences data.
Reprocessed Magnetorheological Elastomers with Reduced Carbon Footprint and their Piezoresistive Properties
Authors: Sedlacik Michal , Ronzova Alena , Munteanu Andrei , Kutalkova Erika , Drohsler Petra , Moucka Robert , Kracalik Milan , Bilek Ondrej , Mazlan Saiful Amri 
Published: April 2022

Abstract
Magnetorheological elastomers (MREs) are widely studied materials, however not many research papers have been initiated on their reprocessing. This paper presents a new type of recyclable MRE which is composed of thermoplastic polyurethane (TPU) and carbonyl iron particles (CI). The chosen TPU can be processed by injection moulding (IM) and allows several reprocessing cycles. Numerous types of injection moulded MREs, which have undergone several recycling cycles, have been prepared. The effect of thermo-mechanical degradation on the recycled MREs has been investigated. An apparent decrease in molecular weight of all examined matrices during reprocessing cycles was observed. These changes are attributed to the intermolecular bonding between the hydroxyl groups on the surface of the CI particles and the matrix. An evaluation of the mechanical properties of the matrices was conducted via tensile strength tests. Generally, MREs suffer from minor degradation due to reprocessing, yet the rheological and piezoresistivity properties are at an acceptable level despite using 100% of recyclates while in real applications only up to 30% of recycled material is used.