bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Cardiovascular Risk Factors and 10-Years Risk for Coronary
Heart Disease in the United Arab Emirates
Authors: Shehab Abdulla , Bakir Sherif , Sabbour Hani , Elnour Asim A. , Mahmeed Wael Al , Salam Amar M. , Kholy Doaa El 
Published: April 2022

Background:
In the United Arab Emirates (UAE), cardiovascular diseases (CVDs) are
the leading cause of mortality, and the incidence of premature coronary heart diseases (CHDs) is
about 10-15 years earlier than that in people of western countries.

Aim:
The current cross-sectional study aims to describe the prevalence of CVD risk factors and estimate
the 10-years risk for CHDs in the population of Abu Dhabi, UAE.

Objective:
The main objective was to report the 10-years risk for CHD in a sample of the UAE
population.

Methods:
We have analyzed the dataset from the Abu Dhabi Screening Program for Cardiovascular
Risk Markers (AD-SALAMA), a population-based cross-sectional survey conducted between
2009 and 2015 (a sample of 1002, 20 to 79 years old without CVDs or diabetes).

Results:
18.0% of our sample have had hypertension (HTN), 26.3% were current smokers, 33%
have had total cholesterol ≥200 mg/dL, 55.0% have had non-high-density lipoprotein (non-HDL)
levels ≥130 mg/dL, 33.1% have had low-density lipoprotein cholesterol (LDL-C) levels ≥130
mg/dL, calculated by β-quantification as 112.3 ± 47.1 mg/dL. 66.8% were overweight or obese,
and 46.2% had a sedentary lifestyle. Nearly 85% of our sample has had one or more major cardiovascular
risk factors.
The estimated 10-year risk of cardiovascular disease according to different risk assessment
tools was as follows: 7.1% according to the national cholesterol education program Framingham
risk score (FRAM-ATP), 2.9% according to Pooled Cohort Risk Assessment Equation
(PCRAE) , 1.4% according to the National Cholesterol Education Program Adult Treatment
Panel III (NCEP ATP III), and 1.1% according to Reynolds Risk Score. Despite the fact that
our sample population have had exhibited major risk factors, the above-mentioned international
scoring systems underestimate the 10-year risk of cardiovascular diseases, given the
high prevalence at younger ages.

Conclusion:
The proportion of modifiable risk factors has been found to be high in the UAE population,
and the majority of them have had one or more risk factors with a higher 10-years risk for
CHDs.
Elucidating the Focal Immunomodulatory Clues Influencing Mesenchymal Stem Cells in the Milieu of Intervertebral Disc Degeneration
Authors: Hechavarria Maite Esquijarosa , Richard Seidu A. 
Published: April 2022

Abstract:The intervertebral discs (IVDs) are a relatively mobile joint that interconnects vertebrae of the spine. Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain, which is most often related to patient morbidity as well as high medical costs. Patients with chronic IVDD often need surgery, that may sometimes lead to biomechanical complications as well as augmented degeneration of the adjacent segments. Moreover, treatment modalities like rigid intervertebral fusion, dynamic instrumentation, as well as other surgical interventions are still controversial. Mesenchymal stem cells (MSCs) have exhibited to have immunomodulatory functions and the ability to differentiate into cartilage, making these cells possibly an epitome for IVD regeneration. Transplanted MSCs were able to repair IVDD back to the normal disc milieu via the activation of the generation of extracellular matrix (ECM) proteins such as aggrecan, proteoglycans and collagen types I and II. IVD milieu clue like, periostin, cluster of differentiation, tumor necrosis factor alpha, interleukins, chemokines, transforming growth factor beta, reactive oxygen species, toll-like receptors, tyrosine protein kinase receptor and disialoganglioside, exosomes are capable of influencing the MSCs during treatment of IVDD. ECM microenvironment clues above have potentials as biomarkers as well as accurate molecular targets for therapeutic intervention in IVDD.
Recent Patents on Plant-Derived Nanoparticles and their Potential
Application Towards Various Cancer Therapeutics
Authors: Santhosh S.B. , Shanmugarama Santny , Ramesh Nimma , Tharik A. Mohamed Sheik , Basamshetty Veera Vijaya 
Published: April 2022

Background:
Nanotechnology plays a vital role in the field of medicine. Especially various nanoparticles such as silver, gold, platinum are involved in the treatment of different types of cancer. The effective nanoparticles were synthesized using techniques like chemical, physical, electrochemical and biological methods. In order to overcome the limitations existing in the synthesis of nanoparticles, researchers turned their attention toward the biological single step nanoparticle synthesis method by using plant and plant products.

Objective:
The objective of this study is to overcome the side effects encountered in the existing anti-cancer agents like nonspecificity and fast excretion, and plant-derived nanoparticles that are eco-friendly, cost-effective and biologically active could serve as a promising alternative.

Conclusion:
From the thorough literature review and recent patents, it is understood that the plant-derived nanoparticles exhibited an excellent anti-proliferation anti-tumor activity towards different types of cancers without affecting the normal cells. Especially, the traditional chemotherapeutic drugs obtained from the plant source incorporated with the nanoparticles show remarkable results against anti cancer studies. The present review focused on some of the existing herbal plant derived nanoparticles, formulations and their potential application in cancer therapeutics.
Celastrus orbiculatus Extract Inhibits the Invasion and Migration of Human Gastric
Cancer Cells in the Hypoxia Microenvironment
Authors: Feng Guangqing , Chu Zewen , Wang Haibo , Liu Yanqing , Zhu Fangshi 
Published: April 2022

Background:
Gastric cancer is a common global disease. So far, the best choice for diagnosis and treatment
of gastric cancer includes surgical resection, chemotherapy, and other targeted drug therapies; however, the overall
survival rate of patients with gastric cancer is still very low. The hypoxic microenvironment facilitates tumor cells to
develop tolerance to chemotherapy and radiotherapy and promotes the early invasion and metastasis of various tumors.
Celastrus Orbiculatus extract (COE) has shown inhibitory activities against a variety of tumor cells. In this study, we
found that COE could inhibit the invasion and migration of gastric cancer cells by inhibiting epithelial-mesenchymal
transformation (EMT) in the hypoxia microenvironment.

Methods:
CoCl2 was first diluted to various concentrations and then used to treat MKN28 and AGS cells. The MTT
(thiazolyl blue) assay was used to evaluate cell proliferation. The transwell assay was used to measure the invasion and
migration abilities of the cells. Wound healing assays were used to detect the healing ability of the cells. Western blotting
was used to assess the effects of COE on the expression of EMT and matrix metalloproteinase (MMP) signaling
pathway-related proteins.

Results:
We found that gastric cancer cells showed stronger proliferation, invasion, and metastasis in the hypoxia
microenvironment. COE inhibited the migration and invasion of AGS and MKN28 cells in both hypoxic and normoxic
environments. Additionally, COE decreased the expression of EMT and MMP signaling pathway-related proteins in
gastric cancer cells.

Conclusion:
Therefore, it can be concluded that COE suppresses the migration and invasion of gastric cancer cells by
inhibiting EMT and MMP in the hypoxia microenvironment.
Recent Trends in Nano-Particulate Carriers for the Diagnosis and Treatment
of Alzheimer’s Disease
Authors: Yadav Awesh K. , Mazahir Farhan 
Published: April 2022

Background:
Alzheimer's disease (AD) is characterized by the presence of aggregated
amyloid fibers, neurodegeneration, and loss of memory. Although "Food and Drug Administration"
(FDA) approved drugs are available to treat AD, drugs that target AD have limited access to the brain
and cause peripheral side effects. These peripheral side effects are the results of exposure of peripheral
organs to the drugs. The blood-brain barrier (BBB) is a very sophisticated biological barrier that allows
the selective permeation of various molecules or substances. This selective permeation by the
BBB is beneficial and protects the brain from unwanted and harmful substances. However, this kind of
selective permeation hinders the access of therapeutic molecules to the brain. Thus, a peculiar drug delivery
system (nanocarriers) is required.

Objective:
Due to selective permeation of the “blood-brain barrier,” nanoparticulate carriers may provide
special services to deliver the drug molecules across the BBB. This review article is an attempt to
present the role of different nanocarriers in the diagnosis and treatment of Alzheimer's disease.

Method:
Peer-reviewed and appropriate published articles were collected for the relevant information.

Result:
Nanoparticles not only traverse the blood-brain barrier but may also play roles in the detection
of amyloid β, diagnosis, and drug delivery.

Conclusion:
Based on published literature, it could be concluded that nano-particulate carriers may
traverse the blood-brain barrier via the transcellular pathway, receptor-mediated endocytosis,
transcytosis, and may enhance the bioavailability of drugs to the brain. Hence, peripheral side effects
could be avoided.
Quality of Life in Menopausal Women with Dental Restorations and Implants
Authors: Stefos Spyridon , Kourtis Stefanos , Vrekoussis Thomas , Augoulea Areti , Kalantaridou Sophia 
Published: April 2022

Aim:
This multicenter study examined the relationship, possible interactions, and intermittent effects that dental implants and prostheses can have on menopausal women’s quality of life as well as provided information regarding the possible side effects of therapeutic regimens on menopause and osteoporosis or osteopenia.

Materials and Methods:
Questionnaires consisted of selected quality of life questions based on specific and additional medical and dental (mainly prosthodontic) questions, which were administered to 100 Greek menopausal/post-menopausal women (Age: Mean Value=63,62 years old) with osteopenia or with or without osteoporosis, with dental implants and implant restorations, or conventional prosthetic restorations visiting two University Hospitals. Menopausal/post-menopausal status was judged on the basis of either secondary, definitive amenorrhoea or based on follicular stimulation hormone ​​(FSH) values, estradiol, and clinical risk factors.

Results:
Participants had a statistically significantly better “functional” and “psychological” feeling after prosthodontic rehabilitation with and without implants. Three out of four reported that their dentist informed them of the possible implant problems that might arise from osteoporosis and its treatment (medications). Moreover, osteopenia was found to be associated with a very lower problem percentage. The bisphosphonate treatment had the highest rate (80%) of reported implant problems than non-bisphosphonate treatment (30%). The hormone replacement therapy (HRT) for menopause was reported to be more associated with problems in implant placement (19%) than in those without treatment (27.3%).

Conclusion:
The questionnaires revealed a significant improvement concerning women’s life quality and well-documented information about the problems their dental implants and restorations may cause in association with menopause and/or osteoporosis.
One Hundred Years of Hypertension Research: Topic Modeling Study
Authors: Abba Mustapha , Nduka Chidozie , Anjorin Seun , Mohamed Shukri , Agogo Emmanuel , Uthman Olalekan 
Published: April 2022

Background
Due to scientific and technical advancements in the field, published hypertension research has developed substantially during the last decade. Given the amount of scientific material published in this field, identifying the relevant information is difficult. We used topic modeling, which is a strong approach for extracting useful information from enormous amounts of unstructured text.

Objective
This study aims to use a machine learning algorithm to uncover hidden topics and subtopics from 100 years of peer-reviewed hypertension publications and identify temporal trends.

Methods
The titles and abstracts of hypertension papers indexed in PubMed were examined. We used the latent Dirichlet allocation model to select 20 primary subjects and then ran a trend analysis to see how popular they were over time.

Results
We gathered 581,750 hypertension-related research articles from 1900 to 2018 and divided them into 20 topics. These topics were broadly categorized as preclinical, epidemiology, complications, and therapy studies. Topic 2 (evidence review) and topic 19 (major cardiovascular events) are the key (hot topics). Most of the cardiopulmonary disease subtopics show little variation over time, and only make a small contribution in terms of proportions. The majority of the articles (414,206/581,750; 71.2%) had a negative valency, followed by positive (119, 841/581,750; 20.6%) and neutral valency (47,704/581,750; 8.2%). Between 1980 and 2000, negative sentiment articles fell somewhat, while positive and neutral sentiment articles climbed substantially.

Conclusions
The number of publications has been increasing exponentially over the period. Most of the uncovered topics can be grouped into four categories (ie, preclinical, epidemiology, complications, and treatment-related studies).
Effect of an Active Video Game Intervention Combined With Multicomponent Exercise for Cardiorespiratory Fitness in Children With Overweight and Obesity: Randomized Controlled Trial
Authors: Comeras-Chueca Cristina , Villalba-Heredia Lorena , Perez-Lasierra Jose Luis , Lozano-Berges Gabriel , Matute-Llorente Angel , Vicente-Rodriguez German , Casajus Jose Antonio , Gonzalez-Aguero Alex 
Published: April 2022

Background
Childhood overweight and obesity have become major global health problems and are negatively related with the cardiorespiratory fitness (CRF) level in school children and adolescents. Exercise, specifically multicomponent training, is effective for CRF improvement, but the main challenge is to ensure adherence to exercise in children with overweight and obesity. Therefore, new ways of exercising that are more attractive and motivational for this population are needed and playing or training with active video games (AVGs) has been proposed as an effective alternative because they require full-body movement and therefore increase energy expenditure.

Objective
The main aim of this study was to investigate the effects of an AVG intervention combined with multicomponent training on CRF at maximal and submaximal intensities in children with overweight or obesity.

Methods
We recruited 28 children (13 girls and 15 boys) aged 9 to 11 years with overweight or obesity from medical centers and divided them into 2 groups, an intervention group (n=20) that participated in a 5-month supervised AVG exercise program combined with multicomponent exercise, and a control group (n=8) that continued daily activities without modification. A maximal stress test to measure CRF using a walking-graded protocol with respiratory gas exchange was performed by the participants.

Results
The AVG group showed a significant decrease in heart rate and oxygen uptake for the same intensities in the submaximal stages of the maximal treadmill test, as well as a lower oxygen uptake percentage according to the individual maximal oxygen uptake, whereas the control group did not show overall changes. No change in the peak oxygen uptake (VO2peak) was found.

Conclusions
A 5-month AVG intervention combined with multicomponent exercise had positive effects on CRF at submaximal intensity, showing a lower heart rate and oxygen uptake at the same intensities and displaying a lower oxygen uptake percentage according to the individual (VO2peak). Greater benefits were found in children with the highest fat percentage.

Trial Registration
ClinicalTrials.gov NCT04418713; https://clinicaltrials.gov/show/NCT04418713
Gestalt Therapy in Brazil
Authors: CIORNAI SELMA 
Published: April 2022

Abstract
This article gives an overview of the Gestalt therapy movement in Brazil, highlighting its special features and characteristics, through comparison of the author's experiences with Gestalt therapy in Brazil and abroad. Attention to group process, the emphasis on the study of Gestalt therapy's philosophical and epistemological foundations, attention to the individual-environment field and sociocultural and economic factors, and community oriented mental health services, as well as the Brazilian style of contact and other cultural differences, are pointed out as a valuable intrinsic part of Gestalt therapy work in Brazil. Furthermore, considering the questionings and transformations that the Gestalt therapy community have had worldwide in the 1980s and 1990s, the author compares Gestalt therapy of yesterday and today, considering gains and losses, and envisioning the future of Gestalt therapy, reflects on some of the challenges she perceives as common to us all.
Evaluación del efecto de la aplicación de fertilizantes químicos y biofertilizantes en el cultivo del cilantro Coriandrum sativum L.
Authors: Artunduga Lemus Fermín , Quintero Guerrero Yaqueline 
Published: April 2022

El cilantro Coriandrum sativum L. es una planta medicinal y aromática herbácea de gran interés industrial debido a sus frutos (semillas). Con el objetivo de evaluar efecto de la aplicación de fertilizantes químicos y biofertilizantes en el cultivo del cilantro, se desarrolló un diseño estadístico completamente al azar con 4 tratamientos que fueron: T0: control, T1: biofertilizante líquido y cosechado a los 20 días, T2: biofertilizante líquido y cosechado a los 40 días, T3: fertilización química + biofertilizante líquido cosechado a los 20 días y T4: fertilización química + biofertilizante líquido cosechado a los 40 días. El experimento se realizó en la granja de Centro Agroempresarial y Desarrollo Pecuario del Huila del Servicio Nacional de aprendizaje (SENA), se utilizaron semillas de cilantro Coriandrum sativum L, variedad patimorado (pureza del 90 %, germinación del 90%) sembrado a chorrillo en tres surcos a una distancia de siembra de 25 cm, en eras de 1 x 7 mts de área. Las variables respuesta que se evaluaron fueron: 1) número de hojas, 2) diámetro y largo del tallo, 3) diámetro y largo de la raíz y 4) peso del hidrolato extraído. Los análisis estadísticos mostraron una diferencia significativa entre el T4 con respecto a los demás tratamientos donde se obtuvo un mayor resultado en el diámetro y largo del tallo, número de hojas y cantidad de hidrolato, mientras que el tratamiento que obtuvo menor diámetro y largo de tallo, número de hojas y cantidad de hidrolato fue el T0 (P ≤ 0,05). En este sentido la utilización de fertilizantes químicos más biofertilizante se convierte en una buena opción que pueden utilizar los agricultores para este tipo de cultivos.
EXTRACCIÓN DE METABOLITOS SECUNDARIOS DE ORÉGANO (ORIGANUM VULGARE) DE DIFERENTES PISOS TÉRMICOS POR EL MÉTODO DE HIDRODESTILACIÓN
Authors: Falla Tapias Sergio , Cárdenas Paula Andrea , Olivar Jorge Mario , Artunduaga Yudy Paola 
Published: April 2022

En el presente trabajo fueron tomadas muestras de orégano (Origanum vulgare) sembradas en los municipios de Zuluaga, Rivera y Garzón. Para el proceso de hidrodestilación fueron tomadas muestras de 200 g. A partir de las muestras analizadas se pudo observar un rendimiento variante que oscilaba entre los 0,3 ml a los 0,7 ml, siendo que las muestras de Zuluaga (que está a más de 2400 m s. n. m.) presentaron mayores rendimientos comparadas con las de los otros municipios. El análisis de cromatografía también mostró que estas mismas muestras presentaban valores de carvacrol y timol más altos (18,80 y 68,40 %, respectivamente), comparadas con las del municipio de Rivera (8, 46 y 57, 51 %) y Garzón (10, 25 y 60, 56 %). Estos compuestos son reconocidos por presentar actividad antimicrobiana y antiparasitaria.
Kaikenlaiselle toiminnalle tilaa riittää, kaikenlaisille seurakuntalaisille paikkoja on
Authors: Ortiz-Nieminen Oscar 
Published: April 2022

Lectio praecursoria: Oscar Ortiz-Niemeisen taidehistorian alan väitöskirja "Kaikenlaiselle toiminnalle tilaa riittää, kaikenlaisille seurakuntalaisille paikkoja on: Monitoimikirkkoarkkitehtuuri Helsingin seudulla 1900–1960-luvuilla" tarkastettiin Helsingin yliopistossa 7.5.2021. Vastaväittäjänä toimi Prof. Pirjo Markkola (Tampereen yliopisto) ja kustoksena Prof. Kirsi Saarikangas (Helsingin yliopisto).
KINGYAW’S RECITING POEM ON AFRO-AMERICAN ACCENT: THE WORLD-ENGLISHES MOVEMENT
Authors: Wijayanti Nurvita , Wilujeng Panggio Restu 
Published: April 2022

Fanon in his book titled ‘Black Skin, White Masks’ says that no matter how smart black people may become, white people will always feel the sense of ‘inferiority’ in which black people speak Pidgin. The sense of imitation of imitating makes the colonizer culture, in which the black people come across inferior from the white’s perspective. KingYaw’s YouTube video tries to break such a false perception. In his video, he talks the way black people have their unique accent It cannot be compared to the Received Pronunciation (BrE). Therefore, this study aims to unravel the linguistic theory on language variation as a part of the World-Englishes movement. This study uses descriptive qualitative method by having one of KingYaw’s video performing and reciting a poem titled “Accent” that was uploaded in YouTube on December 17th, 2018. Post-colonialism allows the people to see the world without discrimination.
FACE THREATENING ACTS (FTAs) IN AIPAC POLITICAL ANNUAL SPEECHES BETWEEN 2006 AND 2012
Authors: Dridi Tarak 
Published: April 2022

Face Threatening Acts are politeness forms which have been struggled over in the past and now as they are pragmatically deemed relevant in identifying centripetal and centrifugal movements exerted by political actors on their interlocutors. The findings on approaching political discourse from politeness perspective have been controversial and ranged from being confined to the interactional level to negotiating implicit power relations.This present study offers a politeness theoretical framework to examine AIPAC political annual speeches between 2006 and 2012. The target of this research is to understand which politeness strategies political actors deploy when addressing the audience and how these political speakers please the other and fulfill political ends. The results display an over-reliance on Face Threatening Acts on record with redressive action at the expense of Face Threatening Acts on record without redressive action and Face Threatening Acts off record. Positive politeness, notably expressive speech acts, play an inclusive role, gain the audience sympathy and reshape public opinion. The study fills the gap in the study of the impact of positive politeness on political discourse and calls for the consideration of expressive speech acts as means of power negotiation rather than mere interaction.