bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Asuhan Kebidanan pada Ny. E Akseptor IUD dengan Menometroragia
Authors: Daen Atika , Kurnaesih Een , S Suryanti 
Published: February 2022

Data WHO menunjukkan bahwa pengguna alat kontrasepsi IUD/AKDR, 30% terdapat di Cina, 13% di Eropa, 5% di Amerika Serikat, 6,7% dinegara– negara berkemabang lainnya. Terdapat peningkatan presentase pemakaian alat kontrasepsi (semua cara) pada Survey Demografi Kesehatan Indonesia (SDKI) dari 62% pada SDKI 2012 menjadi 64% pada SDKI 2017. Namun, presentase putus pakai (Drop Out) kesertaan ber KB masih tinggi yaitu 34%. Kemudian masih besarnya pasangan usia subur (PUS) yang belum terlayani dan belum menggunakan kontrasepsi yang terlihat dari presentase wanita kawin umur 15-49 tahun dengan kebutuhan ber KB yang belum terpenuhi (unmet need) sebesar 11%. Sulawesi selatan cakupan peserta KB aktif di makassar pada tahun 2015. Menujukkan metode kontrasepsi yang terbanyak digunakan adalah suntikan sebanyak 53.200 orang, Pilsebanyak 30.288 orang, Implant sebanyak 14.709 orang, AKDR sebanyak 13.492 orang dan Kondom sebanyak 5.235 orang, Sedangkan metode yang paling sedikit dipilih yaitu, MOP sebanyak 614 orang, MOW sebanyak 4.354 orang (Badan Pusat Statistik, 2016). Tujuan dilakukannya penelitian ini adalah untuk mengetahui dan memahami Asuhan Kebidanan Akseptor KB IUD Pada Ny. “E” Dengan Menometroragia Di RSUD Labuang Baji Makassar tahun 2019 menurut manajemen Varney. Jenis penelitian ini bersifat deskriptif dengan menggunakan metode studi kasus Manajemen Kebidanan yang terdiri dari 7 langkah Varney, yaitu : Pengumpulan data dasar, interpretasi data dasar, diagnosa actual, diagnosa potensial, tindakan segera, rencana asuhan, pelaksanaan asuhan serta mengevaluasi keberhasilannya dari kasus Ny”E” yaitu tanda-tanda vital dalam batas normal, menometroragia belum teratasi namun ibu dapat beradaptasi dengan kondisinya saat ini dan kecemasan teratasi. Penelitian ini, bidan dapat menerapkan manajemen asuhan kebidanan sesuai dengan prioritas masalah pasien secara menyeluruh sehingga tindakan yang akan dilakukan bidan dapat dipertanggung jawabkan berdasarkan metode ilmiah.
Manajemen Asuhan Kebidanan Post Sectio Caesarea Hari Kedua pada Ny. M dengan Nyeri Luka Operasi
Authors: Muliyanti Muliyanti , Hardianti Saputri Linda , Akbar Nurlina 
Published: February 2022

Pada tahun 1985 Organisasi Kesehatan Dunia (WHO) menyatakan: "Tidak ada data pasti untuk wilayah yang memiliki tingkat operasi sesar yang lebih tinggi dari 10-15%", melakukan penelitian pembaruan data, untuk perkiraan yang telah diterbitkan WHO sebelumnya tentang angka operasi sesar di seluruh dunia dan menghitung jumlah tambahan operasi sesar yang akan diperlukan di negara-negara dengan jumlah operasi sesar yang rendah serta jumlah operasi sesar yang berlebihanOperasi sesar juga berkontribusi terhadap angka kematian sekitar 5,8 per 100.000 persalinan juga angka kesakitan operasi sesar lebih tinggi, yakni sekitar 27,3 per 1.000 persalinan, dibandingkan persalinan normal yang hanya 9 per 1.000 persalinan. angka kematian ibu pada operasi sesar adalah 40-80/100.000, lebih besar 25 kali dari persalinan normal. Kesakitan post operasi sesar kira-kira sebesar 15% dan sekitar 90% disebabkan oleh infeksi (endometritis, infeksi saluran kemih dan sepsis karena luka). Komplikasi lebih banyak terjadi setelah bedah sesar darurat (kira-kira 25%) dibanding operasi sesar elektif kira-kira 5%. Angka kesakitan post Sectio Caesarea kira-kira sebesar 15% dan sekitar 90% disebabkan oleh infeksi, maka perubahan fisiologis yang terjadi sangat jelas yaitu nyeri. Tujuan dilakukannya penelitian ini adalah untuk mengetahui tingat nyeri luka Operasi Sectio Caesarea yang dirasakan Ny”M” di RS Bhayangkara Makasasar tahun 2019. Jenis penelitian ini bersifat deskriptif dengan menggunakan metode studi kasus Manajemen Kebidanan yang terdiri dari 7 langkah Varney, yaitu : Pengumpulan data dasar, interpretasi data dasar, diagnosa actual, diagnosa potensial, tindakan segera, rencana asuhan, pelaksanaan asuhan serta mengevaluasi keberhasilannya.Dari kasus Ny”M” yaitu nyeri luka sectio caesarea nyeri belum berkurang namun ibu dapat beradaptasi dengan nyeri(nyeri tingkat 6), tidak terdapat tanda-tanda infeksi.Penelitian ini, bidan dapat menerapkan manajemen asuhan kebidanan sesuai dengan prioritas masalah pasien secara menyeluruh sehingga tindakan yang akan dilakukan bidan dapat dipertanggung jawabkan berdasarkan metode ilmiah.

Kata kunci : operasi sesar;nyeri luka;masa nifas
Manejo clínico-quirúrgico del pie diabético. Un nuevo reto para la Agenda Global 2030 en enfermedades no transmisibles
Authors: Guayán Ardila Ingrid Carolina , Ramírez Espinosa Claudia Marcela , Pardo Patricia 
Published: February 2022

Las personas de la tercera edad con mellitus2 (enfermedad no transmisible), reto en la Agenda Global 2030, cuentan con una amplia desigualdad, abandono familiar y social. En Colombia hay 6,4 millones de pacientes diabéticos, y 92 % de ellos son adultos mayores donde el 25 % tuvieron buen control metabólico. Objetivo: determinar las características clínico-quirúrgicas para el manejo del pie diabético en el adulto mayor en una institución prestadora de salud de tercer nivel en Bogotá, Colombia. Metodología: cuantitativo, descriptivo, observacional de corte transversal. Población: adulto mayor con diagnóstico de diabetes mellitus tipo 2, con neuropatía diabética como complicación microvascular, con algún grado de pie diabético. Resultados: no hay asociación estadísticamente significativa entre las variables sociodemográficas (edad, género, tabaquismo, consumo de alcohol, bajo nivel socioeconómico, aislamiento social) y el sometimiento de los pacientes a cualquier tipo de tratamiento quirúrgico. En pacientes que tuvieron un mal control metabólico y mayores de 70 años, se presentó aumento del riesgo a sufrir amputación, como tratamiento quirúrgico. Conclusiones: el diagnóstico y tratamiento del pie diabético continúa siendo un reto para el sistema en salud; es importante que las instituciones de salud conformen grupos interdisciplinarios donde se incluyan el diagnóstico temprano y seguimiento de la patología, identificando los signos de insuficiencia vascular asociada a la diabetes, las deformidades de los artejos que puedan producir áreas de presión que favorezcan la aparición de úlceras. Este grupo será el encargado de promoción y prevención de los signos de alarma.
THE GENRE FEATURES OF UKRAINIAN BAROQUE SERMON
Authors: Bomko Liliia 
Published: February 2022

This paper is an attempt to comprehend the theoretical preconditions of the genre structure of the Ukrainian baroque sermon in the process of its formation and development starting from “Teaching Gospel” of the early baroque period written by Kyrylo Trankvilion Stavrovetskyi till the homiletic treatise “The Art or the Method of Composing the Sermon” by Ioanykii Galiatovskyi. The forms and principles of coexistence of two homiletical patterns, Greco-Slavic and Latin-Polish, are considered as a channel of rhetorical and stylistic changes that determine genre modifications and varieties. Viewed in this way, the author’s introductions, topics of sermons, and their consistency with different composite parts of the text give grounds to observe the consecutive actualization of the whole conception within the ambit of the whole book and individual sermon samples.
One of the key issues is the interaction of oral and written (book) forms of a sermon, which reveals a double level of communication with the recipient: listening and reading. This is demonstrated by the oral practices of preaching by Kyrylo Trankvilion Stavrovetskyi, Ioanykii Galiatovskyi, Antonii Radyvylovskyi, and Lazar Baranovych, on the one hand. On the other hand, in their collections of sermons named “Key of Understanding”, “Virgin Mary’s Garden”, “Spiritual Sword”, “Trumpets of Sermon Words”, the authors, in addition to the practical part, give some theoretical comments and reflections on their creative process, endowed with divine power.
The development of the theory of Ukrainian baroque preaching was greatly influenced by the homiletic treatise by Ioanykii Galiatovskyi “The Art or the Method of Composing the Sermon”, in which the author consistently elaborates the main issues concerning the theme, composition, examples, and amplification.
Effects of Home-Based Baduanjin Exercise on Left Ventricular Remodeling in Patients With Acute Anterior ST-Segment Elevation Myocardial Infarction: Study Protocol for a Randomized Controlled Trial
Authors: Cai Yinhe , Kang Liang , Li Haiyi , Luo Yuan , Wen Junmao , Gong Zhaohui , Chu Qingmin , Qiu Yijun , Luo Chuanjin , Chen Keyu , Zhao Xinjun , Li Rong 
Published: February 2022

BackgroundLeft ventricular (LV) remodeling after ST-segment elevation myocardial infarction (STEMI) is a major pathological basis associated with heart failure and increased mortality. Exercise-based cardiac rehabilitation has been verified to significantly improve prognosis and quality of life. As a traditional Chinese Qigong, Baduanjin exercise has effectively alleviated adverse LV remodeling in STEMI patients. Despite this, participation in exercise rehabilitation remains low, and home-based exercise rehabilitation may be an alternative approach. Besides, anterior STEMI is reported to have higher risk of adverse LV remodeling. However, the efficiency regarding home-based Baduanjin exercise on LV remodeling in anterior STEMI patients remains uncertain currently.Methods/DesignA single-blind, randomized controlled clinical trial was conducted to explore the efficacy and safety of home-based Baduanjin exercise in anterior STEMI patients compared with moderate intensity aerobic walking. A total of 114 participants were assigned randomly to the Baduanjin group or walking control group at a 1:1 ratio. Eligible participants practiced Baduanjin or walking exercise (5 times a week) for 12 weeks, and then followed up for another 12 weeks. The primary outcome is a relative change in the LV end-diastolic volume. The secondary outcomes include the plasma levels of hypersensitive C-reactive protein and interleukin 6, health-related quality of life measured by EQ-5D-5L, LV ejection fraction, patient health questionnaire-9, generalized anxiety disorder screener-7, short physical performance battery score, and clinical endpoint events. The proportion of circulating regulatory T-cells were also assessed. Adverse events were recorded throughout the trial for safety evaluation. Data were be analyzed by researchers blinded to the treatment allocation.DiscussionThis study provided powerful evidence for the use of home-based Baduanjin exercise in anterior STEMI patients in alleviating LV remodeling and improving clinical outcomes.Trial RegistrationThe Research Ethics Committee of the First Affiliated Hospital of Guangzhou University of Chinese Medicine has approved this study (ZYYECK[2020]045). Written informed consent of patients were required. This trial is registered in the Chinese Clinical Trial Registry (ChiCTR2100047298).DisseminationOur results will be published in peer-reviewed journals and disseminated through academic conferences and the Internet.
Prediction of 2-Year Major Adverse Limb Event-Free Survival After Percutaneous Transluminal Angioplasty and Stenting for Lower Limb Atherosclerosis Obliterans: A Machine Learning-Based Study
Authors: Pan Tianyue , Jiang Xiaolang , Liu Hao , Liu Yifan , Fu Weiguo , Dong Zhihui 
Published: February 2022

BackgroundThe current scoring systems could not predict prognosis after endovascular therapy for peripheral artery disease. Machine learning could make predictions for future events by learning a specific pattern from existing data. This study aimed to demonstrate machine learning could make an accurate prediction for 2-year major adverse limb event-free survival (MFS) after percutaneous transluminal angioplasty (PTA) and stenting for lower limb atherosclerosis obliterans (ASO).MethodsA lower limb ASO cohort of 392 patients who received PTA and stenting was split to the training set and test set by 4:1 in chronological order. Demographic, medical, and imaging data were used to build machine learning models to predict 2-year MFS. The discrimination and calibration of artificial neural network (ANN) and random forest models were compared with the logistic regression model, using the area under the receiver operating curve (ROCAUC) with DeLong test, and the calibration curve with Hosmer–Lemeshow goodness-of-fit test, respectively.ResultsThe ANN model (ROCAUC = 0.80, 95% CI: 0.68–0.89) but not the random forest model (ROCAUC = 0.78, 95% CI: 0.66–0.87) significantly outperformed the logistic regression model (ROCAUC = 0.73, 95% CI: 0.60–0.83, P = 0.01 and P = 0.24). The ANN model the logistic regression model demonstrated good calibration performance (P = 0.73 and P = 0.28), while the random forest model showed poor calibration (P &lt; 0.01). The calibration curve of the ANN model was visually the closest to the perfectly calibrated line.ConclusionMachine learning models could accurately predict 2-year MFS after PTA and stenting for lower limb ASO, in which the ANN model had better discrimination and calibration. Machine learning-derived prediction tools might be clinically useful to automatically identify candidates for PTA and stenting.
Exercise Systolic Reserve and Exercise Pulmonary Hypertension Improve Diagnosis of Heart Failure With Preserved Ejection Fraction
Authors: Verwerft Jan , Verbrugge Frederik H. , Claessen Guido , Herbots Lieven , Dendale Paul , Gevaert Andreas B. 
Published: February 2022

AimsDiastolic stress testing (DST) is recommended to confirm heart failure with preserved ejection fraction (HFpEF) in patients with exertional dyspnea, but current algorithms do not detect all patients. We aimed to identify additional echocardiographic markers of elevated pulmonary arterial wedge pressure during exercise (exPAWP) in patients referred for DST.Methods and ResultsWe identified candidate parameters in 22 patients referred for exercise right heart catheterization with simultaneous echocardiography. Elevated exPAWP (≥25 mmHg) was present in 14 patients, and was best identified by peak septal systolic annular velocity &lt;9.5 cm/s [exS', area under the receiver operating characteristic curve (AUC) 0.97, 95% confidence interval 0.92–1.0] and mean pulmonary artery pressure/cardiac output slope ≥3.2 mmHg/L [mPAP/CO, AUC 0.88 (0.72–1.0)]. We propose a decision tree to identify patients with elevated exPAWP. Applying this decision tree to 326 patients in an independent non-invasive DST cohort showed that patients labeled as “high probability of HFpEF” (n = 85) had reduced peak oxygen uptake [13.0 (10.7–15.1) mL/kg/min, p &lt; 0.001 vs. intermediate/low probability], high H2FPEF score [53 (40–72) %, p &lt; 0.001 vs. intermediate/low probability], and typical clinical characteristics. The diagnostic yield of DST increased from 11% using exercise E/e', to 62% using the decision tree.ConclusionIn DST for suspected HFpEF, exS' was the most accurate echocardiographic parameter to identify elevated PAWP. We propose a decision tree including exS' and mPAP/CO for interpretation of DST. Application of this decision tree revealed typical HFpEF characteristics in patients labeled as high probability of HFpEF, and substantially reduced the number of inconclusive results.
The Impacts of Changes in Anthropogenic Emissions Over China on PM2.5 Concentrations in South Korea and Japan During 2013–2017
Authors: Xie Peifu , Liao Hong 
Published: February 2022

We applied the global 3-D chemical transport model GEOS-Chem to examine the effects of changes in anthropogenic emissions over China on PM2.5 concentrations in South Korea and Japan over 2013–2017 during which the Chinese governmental “Action Plan on the Prevention and Control of Air Pollution” was implemented. The reductions in anthropogenic emissions in China alleviated PM2.5 concentrations in South Korea and Japan. The reductions in anthropogenic emissions in China alone led to reductions in annual mean PM2.5 concentrations by 13.7 (19.7%), 2.7 (7.7%), and 1.0 (7.9%) μg m−3 over 2013–2017 in eastern China, South Korea, and Japan, respectively. The reductions in anthropogenic emissions in China also changed the components of PM2.5 in South Korea and Japan. The concentrations of sulfate, ammonium, black carbon and organic carbon were simulated to decrease and those of nitrate were simulated to increase in both South Korea and Japan. With the changes in anthropogenic emissions and the changes in meteorology (BASE simulation), the proportions of sulfate, nitrate, and OC in PM2.5 in South Korea (Japan) were, respectively, 17.1, 44.4, and 15.8% (27.2, 30.5, and 20.0%) in 2013, and 14.3, 46.0, and 17.8% (23.7, 33.2, and 21.6%) in 2017. Model results shown here are helpful for understanding the temporal evolution in PM2.5 on different timescales in the downwind regions of China.
Role of Suprabasin in the Dedifferentiation of Follicular Epithelial Cell-Derived Thyroid Cancer and Identification of Related Immune Markers
Authors: Tan Hao , Wang Lidong , Liu Zhen 
Published: February 2022

Background: Aberrant regulation of suprabasin (SBSN) is associated with the development of cancer and immune disorders. SBSN influences tumor cell migration, proliferation, angiogenesis, and immune resistance. In this study, we investigated the potential correlation between SBSN expression and immune infiltration in thyroid cancer.Methods: The expression of SBSN in 80 papillary thyroid carcinoma (PTC) specimens was determined using quantitative reverse-transcription polymerase chain reaction, western blotting, and immunohistochemical staining. The expression of SBSN in 9 cases of poorly differentiated thyroid carcinoma (PDTC) and 18 cases of anaplastic thyroid carcinoma (ATC) was evaluated by immunohistochemical staining. Comprehensive bioinformatics analysis of SBSN expression was performed using The Cancer Genome Atlas and Gene Expression Omnibus datasets, and the relationship of SBSN expression with M2 macrophages and T regulatory cells (Tregs) in ATC and PTC was verified by immunohistochemical staining.Results: Compared with those in adjacent normal tissues, the expression levels of SBSN mRNA and protein were significantly higher in PTC tissues. SBSN expression level was correlated with that of cervical lymph node metastasis in PTC patients. Immunohistochemical staining results showed statistically significant differences among high-positive expression rates of SBSN in PTC, PDTC, and ATC. Functional enrichment analysis showed that SBSN expression was associated with pathways related to cancer, cell signaling, and immune response. Furthermore, analysis of the tumor microenvironment (using CIBERSORT-ABS and xCell algorithms) showed that SBSN expression affected immune cell infiltration and the cancer immunity cycle, and immunohistochemistry confirmed a significant increase in M2 macrophage and Treg infiltration in tumor tissues with high-positive SBSN expression.Conclusion: These findings reveal that SBSN may be involved in thyroid carcinogenesis, tumor dedifferentiation progression, and immunosuppression as an important regulator of tumor immune cell infiltration.
LPIN1 Is a Regulatory Factor Associated With Immune Response and Inflammation in Sepsis
Authors: Dai Wei , Zheng Ping , Luo Deqiang , Xie Qian , Liu Fen , Shao Qiang , Zhao Ning , Qian Kejian 
Published: February 2022

ObjectivesSepsis is a clinical disease that is typically treated in the intensive care unit, and the complex pathophysiology under this disease has not been thoroughly understood. While ferroptosis is involved in inflammation and infection, its effect in sepsis is still unknown. The study aimed to identify ferroptosis-related genes in sepsis, providing translational potential therapeutic targets.MethodsThe dataset GSE65682 was used to download the sample source from the Gene Expression Omnibus (GEO) database. Consensus weighted gene co-expression network analysis (WGCNA) was performed to find suspected modules of sepsis. The differentially expressed genes (DEGs) most significantly associated with mortality were intersected with those altered by lipopolysaccharide (LPS) treatment and were further analyzed for the identification of main pathways of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The related pathway markers were further verified by qPCR.ResultsA total of 802 blood samples with sepsis were included for WGCNA, which identified 21 modules. Intersected with ferroptosis databases and LPS treatment groups, we identified two ferroptosis-related genes: PEBP1 and LPIN1. Only LPIN1 contributes to a poor outcome. Then, 205 DEGs were further identified according to the high or low LPIN1 expression. Among them, we constructed a gene regulatory network with several transcriptional factors using the NetworkAnalyst online tool and identified that these genes mostly correlate with inflammation and immune response. The immune infiltration analysis showed that lower expression of LPIN1 was related to macrophage infiltration and could be an independent predictor factor of the survival status in sepsis patients. Meanwhile, the multivariate Cox analysis showed that LPIN1 had a significant correlation with survival that was further verified by in vitro and in vivo experiments.ConclusionIn conclusion, LPIN1 could become a reliable biomarker for patient survival in sepsis, which is associated with immune and inflammation status.
Refining a Protocol for Faecal Microbiota Engraftment in Animal Models After Successful Antibiotic-Induced Gut Decontamination
Authors: Amorim Nadia , McGovern Emily , Raposo Anita , Khatiwada Saroj , Shen Sj , Koentgen Sabrina , Hold Georgina , Behary Jason , El-Omar Emad , Zekry Amany 
Published: February 2022

BackgroundThere is mounting evidence for the therapeutic use of faecal microbiota transplant (FMT) in numerous chronic inflammatory diseases. Germ free mice are not always accessible for FMT research and hence alternative approaches using antibiotic depletion prior to FMT in animal studies are often used. Hence, there is a need for standardising gut microbiota depletion and FMT methodologies in animal studies. The aim of this study was to refine gut decontamination protocols prior to FMT engraftment and determine efficiency and stability of FMT engraftment over time.MethodsMale C57BL/6J mice received an antibiotic cocktail consisting of ampicillin, vancomycin, neomycin, and metronidazole in drinking water for 21 days ad libitum. After antibiotic treatment, animals received either FMT or saline by weekly oral gavage for 3 weeks (FMT group or Sham group, respectively), and followed up for a further 5 weeks. At multiple timepoints throughout the model, stool samples were collected and subjected to bacterial culture, qPCR of bacterial DNA, and fluorescent in-situ hybridisation (FISH) to determine bacterial presence and load. Additionally, 16S rRNA sequencing of stool was used to confirm gut decontamination and subsequent FMT engraftment.ResultsAntibiotic treatment for 7 days was most effective in gut decontamination, as evidenced by absence of bacteria observed in culture, and reduced bacterial concentration, as determined by FISH as well as qPCR. Continued antibiotic administration had no further efficacy on gut decontamination from days 7 to 21. Following gut decontamination, 3 weekly doses of FMT was sufficient for the successful engraftment of donor microbiota in animals. The recolonised animal gut microbiota was similar in composition to the donor sample, and significantly different from the Sham controls as assessed by 16S rRNA sequencing. Importantly, this similarity in composition to the donor sample persisted for 5 weeks following the final FMT dose.ConclusionsOur results showed that 7 days of broad-spectrum antibiotics in drinking water followed by 3 weekly doses of FMT provides a simple, reliable, and cost-effective methodology for FMT in animal research.