bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Secretor Status with Enteropathy and Growth among Children in Bangladesh Aged 1–24 Months
Authors: Palit Parag , Ahmed Mondar Maruf Moin , Gazi Md Amran , Haque Md Ahshanul , Alam Md Ashraful , Haque Rashidul , Mahfuz Mustafa , Ahmed Tahmeed 
Published: July 2022

ABSTRACT.
Secretor status refers to the ability of an individual to secrete blood group antigens into body fluids and onto the different epithelial surfaces. Concurrent findings have demonstrated an association of the secretor status of children with susceptibility to a plethora of enteropathogens. We aimed to determine a possible association of secretor status of children with childhood enteropathy, an important causal factor for childhood growth failure. Participants of the Malnutrition and Enteric Disease (MAL-ED) birth cohort study from the Bangladesh site were enrolled along with their mothers. Saliva was analyzed for determining blood groups and secretor status of the children and their mothers by using an in-house ELISA. Approximately 59% of children and 65% of mothers were found to be secretor positive. Secretor-positive children were found to have a significantly positive association with alpha-1-antitrypsin (β-coefficient: 0.11, 95% CI: 0.07, 0.21, P < 0.01) and with environmental enteric dysfunction score (β-coefficient: 0.32, 95% CI: 0.29, 0.65, P = 0.05). However, despite a negative effect size, secretor-positive children did not show any statistical significance with length-for-age and weight-for-age z scores (LAZ and WAZ), respectively. Our findings indicate toward the genetic factor of secretor status of children being associated with childhood growth faltering, through increased susceptibility to distinct enteropathogens and the consequent development of enteric inflammation and enteropathy among children. However, these findings are only applicable in Bangladeshi settings and thus need to be validated in several other similar settings, to establish a possible relationship between the secretor status of children with enteropathy and resulting childhood growth failure.
Sawur Or Sawer Rite: the Perspective of Death Javanese-Sundanese Tradition In Catholic Church
Authors: Jatmiko Nikasius 
Published: July 2022

Death is a certainty that humans cannot avoid. Everyone will face this event without exception. The difference lies in respecting the corpse before it is buried or cremated. Each region has its peculiarities in building a death ceremony. Culture plays a significant role in shaping the death ceremony based on local wisdom. These rites lead to the same goal: placing death as a noble act. This study aims to preserve and explore cultural wealth that is becoming extinct according to the times. These methods show that humans have a high value and dignity compared to other creations, even though they have died. This value is maintained through various very noble awards. Javanese and Sundanese have similarities in respecting the bodies to be buried. The ritual of sawer or sawur is a value that distinguishes it from other cultures. Local wisdom is still maintained, even though modernity has begun to erode it.
Antibodies to domain I β2 -glycoprotein 1 in patients with antiphospholipid syndrome and systemic lupus erythematosus
Authors: Cheldieva F. A. , Reshetnyak T. M. , Cherkasova M. V. , Glukhova S. I. , Lila A. M. , Nasonov E. L. 
Published: July 2022

The study of antiphospholipid antibodies (aPL), not included in the Sydney diagnostic criteria, in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) is poorly understood.The aim of this study – to determine the clinical significance of IgG antibody testing for domain I β2 -glycoprotein 1 (β2 -GP1DI) – IgG anti-β2 -GP1DI in patients with APS with and without SLE.Materials and methods. The study included 187 patients with APS with or without SLE, 49 patients formed a comparison group, and 100 relatively healthy individuals formed a control group. IgG/IgM antibodies to cardiolipin and IgG/ IgM anti-β2 -GP1 were determined by enzyme immunoassay (ELISA) in patients with or without APS, and IgG antiβ2 -GP1DI was determined by chemiluminescence assay in all patients and controls.Results. IgG anti-β2 -GP1DI was detected in 37 (71%) of 52 patients with primary APS (PAPS), in 6 (50%) of 12 patients with probable APS, in 42 (71%) of 59 patients with SLE+APS, in 17 (26%) of 64 patients with SLE, in 1 (2%) of comparison group and in none of control group. IgG anti-β2 -GP1DI was significantly associated with PAPS and SLE+APS compared with patients with SLE (p=0.0002 and p=0.0001, respectively). The association of IgG anti-β2 -GP1DI with clinical manifestations of APS (thrombosis (χ2 =9.69; p=0.001) and obstetric pathology (χ2 =4.19; p=0.04)) was detected. There was a significant association of IgG anti-β2 -GP1DI with arterial thrombosis (χ2 =8.84; p=0.002) and with late gestational obstetric pathology (χ2 =6.35; p=0.01). High specificity of IgG anti-β2 - GP1DI depending on the diagnosis and clinical manifestations of APS was noted despite low sensitivity: specificity for thrombosis was 84%, for obstetric pathology – 94%, for APS – 89%. Isolated IgG anti-β2 -GP1DI positivity was reported in 2% of 50 aPL negative patients and was not associated with APS manifestations.Conclusion. The frequency of IgG anti-β2 -GP1DI detection was higher in patients with APS compared to patients with SLE, comparison group and control (p<0.05). Positive IgG anti-β2 -GP1DI values were significantly associated with thrombotic complications and with obstetric pathology (χ2 =8.84; p=0.002 and χ2 =6.35; p=0.01). Specificity>˂ 0.05). Positive IgG anti-β2 -GP1DI values were significantly associated with thrombotic complications and with obstetric pathology (χ2 =8.84; p=0.002 and χ2 =6.35; p=0.01). Specificity of IgG anti-β2 -GP1DI for APS and its clinical manifestations (thrombosis and obstetric pathology) was higher than sensitivity: 89%, 94%, and 84%, respectively.
Using asynchronous quantitative computed tomography for opportunistic screening of osteoporosis
Authors: Petraikin A. V. , Toroptsova N. V. , Nikitsinskaya O. A. , Kuznetsov S. Yu. , Nisovtsova L. A. , Akhmad E. S. , Artykova Z. R. , Semenov D. S. , Sergunova K. A. , Vladzymyrskyy A. V. , Morozov S. P. 
Published: July 2022

The aim– to determine the possibility of identifying individuals with osteoporosis using asynchronous computed quantitative tomography (CT) of the proximal femur by comparison with dual-energy X-ray absorptiometry (DХA).Materials and methods. The study included 40 postmenopausal women and 6 men over 50 years old (Me of age – 72.5 [65.3; 77.7] years) referred by the attending physician for densitometric examination. The patients signed an informed consent. The measurements were performed on a DXA with a narrow fan beam (Lunar Prodigy Advance, GE Healthcare, USA), and QCT on the Aquilion 64 (Canon Medical Systems, Japan). Correlation analysis and comparison of projected bone mineral density (BMD), bone mineral content (BMC), measurement area and T-score using the Blend – Altman method were carried out.Results. A statistically significant correlations were revealed between the indicators of DXA and asynchronous QCT: for femoral neck BMD r=0.93; for the T-score r=0.93; for the total hip – r=0.91 and r=0.91 respectively. When conducting the analysis using the Blend – Altman method, it was found that the QCT underestimated the value of the femoral neck BMC (bias –0.923 g), covered a smaller area of interest (bias 0.376 cm2 ), and therefore there was a shift in the values of BMD by –0.224 g/cm2 . The value of the T-score for the femoral neck had bias –0.29 standard deviations (SD), and for the total hip –0.72 SD, which were statistically significant.Conclusions. There was a high correlation between quantitative indicators of bone tissue of the proximal hip, assessed using QCT and DXA. The BMD and T-score values for the femoral neck and the total hip at QCT were lower compared to the values of the DXA results. Considering the conducted research, it is recommended that when introducing asynchronous QCT into clinical practice to identify people with osteoporosis, a synchronous phantom should be pre-scanned to compare the QCT and DXA results, followed by adjusting the BMD and T-score values for QCT by the average difference between them.
Cerebrovascular reactivity depending on rheumatoid factor and anticitrullinated protein antibody positivity in hypertensive patients with rheumatoid arthritis
Authors: Rebrova N. V. , Sarkisova O. L. , Ripp T. M. , Karpov R. S. , Mordovin V. F. 
Published: July 2022

Objective – to investigate cerebrovascular reactivity (CVR) depending on rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) positivity in hypertensive patients with rheumatoid arthritis (RA).Subjects and methods. A single cross-sectional study included 61 patients (mean age 59.8±7.7 years; 6 men and 55 women) with combined RA and grade 1–2 hypertension (HTN). The duration of RA was 11.2±7.4 years. The duration of HTN was 12.1±8.6 years. All patients were treated with methotrexate. RA patients were categorized into RF/ACPA seronegative and RF/ACPA seropositive subgroups. CVR was evaluated by bilateral transcranial Doppler sonography of the middle cerebral arteries (MCA) in a hyperoxic test (O2 CVR) and in a hypercapnic test (CO2 CVR). We measured MCA mean blood flow velocity (Vmn), time average maximal blood flow velocity (TAMX), peak systolic velocity (Vps) at baseline, within 2 minutes of 100% oxygen inhalation and within 3 minutes of recovery phase (hyperoxic test). We calculated the following indicators for assessing CVR: index changes of flow velocity mean (IFVm), speed modification of velocity (SMFVm) and normalized answer of reserve (NAR). Then, according to the same scheme, we performed a hypercapnic test with the inhalation of a 4% mixture of carbon dioxide with air. Values are presented as Me [Q1 ; Q3 ].Results and discussion. Hypertensive patients with RA had a decrease in response power of MCA blood flow to hyperoxia. RF-seropositive RA patients had a more pronounced decrease in the power of the response to hyperoxia compared with RF-seronegative RA patients. The values of IFVm in the hyperoxic test were –13.4 [–19.9; –0.9] versus –16.2 [–22.7; –13.4]% (р=0.0453), respectively. ACPA-seropositive RA patients had not only a more pronounced decrease in the power of the response of MCA blood flow to hyperoxia, but also a more pronounced slowdown in the response velocity of MCA blood flow to hyperoxia compared with ACPA-seronegative RA patients. The values of IFVm in the hyperoxic test were –9.74 [–15.9; 2.84] versus –20.9 [–25.0; –14.7]% (р=0.0062), the values of SMFVm were –0.05 [–0.09; 0.02] versus –0.09 [–0.20; –0.05] sm/s2 (р=0.0488) respectively. Combined RA and HTN patients had a decrease in response power of MCA blood flow to hypercapnia. However, no statistical differences were found in the state of CO2 CVR between patients with seropositive RA and seronegative RA.Conclusion. Hypertensive patients with seropositive RA have a more pronounced O2 CVR disorder in compared to seronegative RA patients.
Contributing factors of diabetes mellitus among patients with gout (results of the long-term prospective study)
Authors: Zheliabina O. V. , Eliseev M. S. , Glukhova S. I. , Nasonov E. L. 
Published: July 2022

It is assumed that the risk of developing type 2 diabetes mellitus (T2DM) in patients with gout is influenced by both generally accepted risk factors and factors related to gout.Objective. To evaluate the impact of various risk factors for T2DM in patients with gout.Material and methods. 444 patients (49 women, 395 men) ≥18 years old with gout and without DM were included. Duration of observation was 5.66 [2.69; 7.64] g. To identify factors associated with the risk of developing T2DM, multivariate logistic regression was used, which included: sex; T2DM in relatives; insufficient physical activity; unbalanced diet; age ≥45 years; ≥4 attacks per year; presence of tophi; BMI≥30 kg/m2 ; allopurinol, febuxostat, glucocorticoids, diuretics, metformin, colchicine; GFR<60 ml/min/1.73 m2 ; serum uric acid level (sUA) ≥420 μmol/l and ≥480 μmol/l. Results. T2DM developed in 108 (24.3%) patients. According to the multivariate model, the presence of ≥4 attacks of arthritis per year increased the risk of T2DM (OR=5.23; 95% CI: 2.98–9.19; p=0.0001); presence of tophi (OR=2.61; 95% CI: 1.50–4.54; p=0.001); sUA≥480 μmol/l (OR=2.26; 95% CI: 1.02–5.00; p=0.144), diuretics (OR=2.35; 95% CI: 1.19–4.64; p=0.014). Febuxostat (OR=0.31; 95% CI: 0.11–0.84; p=0.022) and metformin (OR=0.49; 95% CI: 0.21–1.16; p=0.107) reduced the risk of developing T2DM. Conclusion. Risk of T2DM in patients with gout is associated with high incidence of arthritis attacks, MK≥480 μmol/l, hypertension, diuretic use, and febuxostat and metformin reduces risk. Key words: gout, type 2 diabetes mellitus, uric acid>˂ 60 ml/min/1.73 m2 ; serum uric acid level (sUA) ≥420 μmol/l and ≥480 μmol/l.Results. T2DM developed in 108 (24.3%) patients. According to the multivariate model, the presence of ≥4 attacks of arthritis per year increased the risk of T2DM (OR=5.23; 95% CI: 2.98–9.19; p=0.0001); presence of tophi (OR=2.61; 95% CI: 1.50–4.54; p=0.001); sUA≥480 μmol/l (OR=2.26; 95% CI: 1.02–5.00; p=0.144), diuretics (OR=2.35; 95% CI: 1.19–4.64; p=0.014). Febuxostat (OR=0.31; 95% CI: 0.11–0.84; p=0.022) and metformin (OR=0.49; 95% CI: 0.21–1.16; p=0.107) reduced the risk of developing T2DM.Conclusion. Risk of T2DM in patients with gout is associated with high incidence of arthritis attacks, MK≥480 μmol/l, hypertension, diuretic use, and febuxostat and metformin reduces risk.
Acerca do sujeito, da pessoa e do Direito nos Grundrisse; On subject, Person and Law in Grundrisse
Authors: Sartori Vitor 
Published: July 2022

No presente artigo, a partir daquilo que o filósofo brasileiro José Chasin chamou de análise imanente, abordaremos o Direito nos Grundrisse, procurando demonstrar que a crítica pachukaniana ao Direito – ao relacionar forma jurídica e a forma mercadoria – traz aspectos essenciais para a compreensão da posição de Marx sobre a esfera jurídica. Porém, a análise do autor alemão é mais ampla, e destaca também a ligação das relações jurídicas com aspectos essenciais da forma dinheiro, bem como da esfera da distribuição. Outra questão de grande importância é que a crítica marxiana tem um tratamento mais detido que aquela de Pachukanis tanto sobre a autonomização do Direito quanto no que diz respeito à correlação entre a lei do valor, a formação de sujeitos na sociedade capitalista e as categorias jurídicas.
Abstract
In this article, with José Chasin´s Immanent analysis, we will analyze Law in the Grundrisse, intending to demonstrate that Pachukan's criticism of Law - relating legal form and form of commodity - brings essential aspects for the understanding of Marx's position on the juridical sphere. However, an analysis by the German author is more comprehensive and allow us to link legal relationships with essential aspects of the money form, as well as of distribution. Another issue of great importance is the Marxian criticism that deals with a treatment more careful than the pachukanian of both, the autonomy, and the correlation between a law of value, the formation of Subjects in capitalist society and juridical categories. In this sense, we will bring a different approach to the hegemonic one in Brazil, represented by the Pachukanian tradition. We try to demonstrate that, even in the Grundrisse, in which the notion of subject and person are more recurrent, there is not an identification between these categories and the notion of subject of rights, always highlighted by authors such as Márcio Naves and Alysson Mascaro, as well as by their followers, as something central to the Marxist critique of Law.
Considerações Hegelianas sobre a relação entre religião cristã e estado moderno
Authors: Luchi José Pedro 
Published: July 2022

Esse artigo trata das relações entre Estado e religião cristã, como colocadas em alguns escritos de Hegel, fundamentais para esse tema, a partir da interpretação de E. Boeckenfoerde. Arrancando-se da concepção hegeliana de Estado substancial que depende da religião para sua sustentação espiritual, chega-se às conseqüências de uma vinculação entre ambas as instâncias, como relações de reconhecimento mútuo. A consideração das diferenças da posição hegeliana diante da posição hoje predominante da neutralidade do Estado em relação a imagens religiosas do mundo é abordada nesse artigo, que conclui com reflexões sobre a nossa situação contemporânea em relação à temática em estudo.
O Gênero Humano e a origem da Justiça: Rousseau e a tradição de Pufendorf
Authors: De Lucena André Queiroz 
Published: July 2022

Examinaremos aspectos do debate acerca da concepção de Gênero Humano e da aplicação da Justiça e da Vontade Geral, constituintes do corpo político, em Pufendorf, Diderot e Rousseau. Apontaremos, portanto, o tema no jusnaturalismo de Pufendorf, expresso no Le droit de la nature et de gens que inspira algumas passagens políticas da Enciclopédia; no verbete “Direito Natural” de Diderot; e, parte do projeto teórico-político de Rousseau, apontaremos a crítica do genebrino àquela tradição.
La Mettrie: nem santo, nem pecador.
Authors: Bocca Francisco Verardi 
Published: July 2022

Neste artigo procuro desfazer a opinião compartilhada entre leitores e historiadores da filosofia que consideram imoralista tanto a pessoa como a obra do médico-filósofo Julien Offray de La Mettrie, portanto perniciosa e merecedora das censuras sofridas. De suas causas, destaco as biografias dedicadas a ele. Também o recurso que Marquês de Sade, ao adotá-lo como seu filósofo, fez de suas teses, atribuindo-lhe sua inspiração hedonista e libertina. Por último, o histrionismo de seus escritos. Todas podem ser questionadas, mas somente a leitura atenta de sua obra pode lhe fazer justiça. Quanto aos biógrafos nada tenho a dizer. Quanto a Sade, me apoio em Jean Dupran (1976), para quem realizou uma apropriação tendenciosa de suas teses. Assim, apresentarei um confronto entre as obras L`homme machine (1747) e Anti-Sénèque (1748), a fim de melhor compreender sua noção de moralidade, prazer, remorso, convívio social e o papel da filosofia na construção da felicidade virtuosa, longe da imoderação e devassidão que o público lhe atribui.
Sobre a prudência, da educação e da filosofia
Authors: Hardt Lucia Schneider , Moura Rosana Silva de 
Published: July 2022

Resumo: Nosso propósito neste ensaio é o de pensar alguns elementos da constelação do cenário da educação brasileira, tendo em vista o aporte filosófico de Nietzsche e Gadamer. Pretendemos discutir aspectos da formação humana - questão filosófica de primeira grandeza na Área de Filosofia da educação, considerando as contribuições destes dois filósofos alemães que olharam de modo crítico para a tradição, sem descartá-la, ao contrário, fortalecendo justamente o conceito de formação por um esforço grandioso de torná-la verdadeiramente autêntica. O olhar crítico persegue não apenas a destruição do que é limitante na tradição, mas quer também destacar aquilo que ainda pode fazer sentido no instante da queda do humano em face da destruição e de sua inexorável busca pela educabilidade humana. Palavras-chave: Educação. Nietzsche. Gadamer.
Effect of the Tempering Process on the Corrosion Performance of Wire Arc Additively Manufactured 420 Martensitic Stainless Steel
Authors: Lunde Jonas , Salahi Salar , Vahedi Nemani Alireza , Ghaffari Mahya , Nasiri Ali 
Published: July 2022

With the aim of modifying the microstructure and improving the corrosion performance of a wire arc additive manufactured 420 martensitic stainless steel, heat treatment cycles consisting of austenitizing at 1,150°C followed by air cooling and subsequent tempering at different temperatures (300°C, 400°C, 500°C, and 600°C) were applied to the as-printed alloy. Microstructural analysis revealed that the austenitization and subsequent air-cooling treatment led to the removal of retained austenite and delta ferrite from the as-printed structure, while the tempering process resulted in the precipitation of a variety of carbide particles at different tempering temperatures. Electrochemical tests performed in an aerated 3.5 wt% NaCl solution showed that tempering at 400°C led to the highest corrosion resistance, while tempering at 500°C deteriorated the alloy’s resistance against localized corrosion. The most stable passive layer was found to form on the 400°C tempered sample due to the uniformity of Cr-concentration in the formed carbide precipitates and their surrounding matrix. However, Cr-rich carbide precipitates formed in the 500°C tempered sample were found to deteriorate the passive film stability throughout the immersion time in the electrolyte.
Drug-eluting versus nondrug peripheral vascular interventions
Authors: Enezate Tariq , Bath Anandbir , Chinta Viswanatha , Omran Jad 
Published: July 2022

IntroductionDrug-eluting (DRUG) peripheral vascular interventions (PVIs) are associated with higher patency rates than nondrug (NONDRUG) PVIs. Recent data raised safety concerns with using DRUG devices in PVIs.Material and methodsThe study population was extracted from the 2016 Nationwide Readmissions Database using the International Classification of Diseases, tenth edition, clinical modifications/procedure coding system codes for PVI, DRUG and NONDRUG devices, and in-hospital procedural complications. Study endpoints included in-hospital all-cause mortality, length of index hospitalization, acute kidney injury (AKI), amputation, compartment syndrome, vascular complications, bleeding, and blood transfusion. Propensity matching was used to adjust for baseline characteristics.Results49,883 discharged patients who underwent lower extremity arterial PVI were identified, 25.3% DRUG and 74.7% NONDRUG PVI. Mean age was 68.3 years and 40.6% were female. Critical limb ischemia was reported in 33.2%, claudication in 7.6%, and acute limb ischemia in 0.1%. In comparison to the NONDRUG group, the DRUG group was associated with lower in-hospital all-cause mortality (2.2 vs. 2.9%, p < 0.001), shorter length of index hospitalization (8.3 vs. 8.6 days, p = 0.001), bleeding (12.0% vs. 13.5%, p < 0.001), and need for blood transfusion (10.1% vs. 11.0%, p = 0.004). There was no significant difference in terms of AKI (17.3% vs. 18.0%, p = 0.10), amputation (15.3% vs. 15.4%, p = 0.63), compartment syndrome (0.5% vs. 0.6%, p = 0.07), or vascular complications (0.8% vs. 0.8%, p = 0.50). After propensity matching, the mortality benefit was no longer present.ConclusionsDRUG PVI was associated with lower in-hospital all-cause mortality, bleeding events and shorter length of index hospitalization and comparable vascular-related complications. However, this mortality benefit was no longer present after propensity matching.