bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected Factors Affecting the Kinetics of Guest Molecule Release from Investigation of Binary Chemical Systems Trapped in a Single Void of Mesoporous Silica Particles
Authors: Trzeciak Katarzyna , Wielgus Ewelina , Kaźmierski Sławomir , Khalaji Mehrnaz , Dudek Marta K. , Potrzebowski Marek J. 
Published: December 2022

AbstractIn this work, we present results for loading of well‐defined binary systems (cocrystal, solid solution) and untreated materials (physical mixtures) into the voids of MCM‐41 mesoporous silica particles employing three different filling methods. The applied techniques belong to the group of “wet methods” (diffusion supported loading – DiSupLo) and “solvent‐free methods” (mechanical ball‐mill loading – MeLo, thermal solvent free – TSF). As probes for testing the guest1‐guest2 interactions inside the MCM‐41 pores we employed the benzoic acid (BA), perfluorobenzoic acid (PFBA), and 4‐fluorobenzoic acid (4‐FBA). The guests intermolecular contacts and phase changes were monitored employing magic angle spinning (MAS) NMR Spectroscopy techniques and powder X‐ray diffraction (PXRD). Since mesoporous silica materials are commonly used in drug delivery system research, special attention has been paid to factors affecting guest release kinetics. It has been proven that not only the content and composition of binary systems, but also the loading technique have a strong impact on the rate of guests release. Innovative methods of visualizing differences in release kinetics are presented.
Advances in Low‐Temperature Dual‐Ion Batteries
Authors: Yu Dandan , Li Kexin , Ma Guiyou , Ru Fei , Zhang Xiaokun , Luo Wen , Hu Pengfei , Chen Da , Wang Hua 
Published: December 2022

AbstractFabricating rechargeable batteries for low‐temperature (LT) applications is highly desired at high altitudes/latitudes, aerospace/subsea exploration, and defense. Lithium‐ion batteries (LIBs) suffer from severe loss of capacity and energy/power density at sub‐zero temperatures caused by the sluggish kinetics. By utilizing both cations and anions as charge carriers, dual‐ion batteries (DIBs) become a nascent battery system for LT tolerance by overcoming ion‐desolvation during discharge. Here, we summarize recent advances in LT DIBs. To begin with, distinctive advantages of DIBs at LTs are highlighted compared to LIBs, with a special attention to anion (de‐)intercalation, and the in‐depth understanding of key challenges for LT operation is discussed. The next major section deals with the exciting progress on the advanced strategies to improve the LT performance of DIBs, including alternative electrode materials, reliable electrolyte formulations, and construction of interphase protective layers. Finally, prospects and future developments in this exciting field of LT DIBs are suggested.
Different fluid strategies for the simulation of a Helicon Plasma Thruster
Authors: Souhair Nabil , Ponti Fabrizio , Magarotto Mirko , Pavarin Daniele 
Published: December 2022

AbstractDifferent fluid numerical strategies have been considered for the analysis of the plasma transport in a Helicon Plasma Thruster, namely the Drift Diffusion solution, the explicitly segregated solution, and the adoption of the Simple algorithm [Patankar & Spalding] for the coupled solution of the continuity and momentum balances. These strategies have been compared in terms of plasma profiles such as electron density and temperature, and their computational efficiency has been assessed. Finally, a sensitivity analysis over the neutrals' pressure has been performed in order to assess the validity of each proposed strategy for different collisional regimes.
Curves for Curlew: Identifying Curlew breeding status from GPS tracking data
Authors: Bowgen Katharine M. , Dodd Stephen G. , Lindley Patrick , Burton Niall H. K. , Taylor Rachel C. 
Published: December 2022

AbstractIdentifying the breeding status of cryptic bird species has proved problematic without intense or inherently expensive monitoring. Most, if not all, intensive bird monitoring comes with disturbance risks and many projects now rely on tagging of individuals to provide remote information on movements. Given the importance of breeding status when targeting conservation interventions novel methods are needed. This study aimed to identify breeding status in Eurasian Curlew (Numenius arquata) from GPS tag movement patterns using the “recurse” package in R. This package identifies foci of activity (using K‐means clustering) based on revisitations. Using a training data set from an individual of known breeding status, we visually assessed the frequency of revisits to particular locations to identify prebreeding, incubation, chick guarding, and post‐breeding stages to an accuracy of a within at most half a day and thus breeding outcomes. Limited validation was provided by additional field observations. Based on our results, we estimate a low daily nest survival rate of 0.935 during incubation, that only a small proportion of individuals successfully raised young, and that there was a high proportion (26%) of non‐breeders in the population. The Eurasian Curlew is a species of high conservation concern across Europe, and our results concur with recent studies highlighting that population declines are likely to be driven by low levels of productivity. The acquisition of improved knowledge on the behaviors of individuals at each stage of breeding enables more targeted conservation efforts and reduces the need for additional monitoring visits that may cause increased disturbance and risk of nest failure. We hope that the approach outlined may be developed to provide practitioners who have detailed knowledge of the behavior of their study species with a practical means of assessing the breeding status and outcomes of their study populations.
Effect of COVID‐19 on healthcare workers' morbidity and mortality compared to the general population in Kohgiluyeh and Boyer‐Ahmad Province, Iran
Authors: Jalil Mohsen , Ashkan Zahra , Gholamnezhad Mohammad , Jamalidoust Somayeh , Jamalidoust Marzieh 
Published: December 2022

AbstractDuring the Covid‐19 pandemic, the adverse effects of recent coronaviruses on healthcare professionals cannot be ignored. This study compared the admission rates due to Covid‐19 and characteristics of hospitalized healthcare workers with the general population of Kohgiluyeh and Boyer‐Ahmad (K.B) province. 18546 hospitalized patients infected with Covid‐19 in hospitals in four cities of K.B province were enrolled in this study; of them, 236 (1.27%) patients were healthcare workers. Demographic and clinical data of hospitalized cases due to Covid‐19 infection were collected from August 2020 to September 2021. The underlying diseases were also considered in this study. According to our findings, 55.5% of the hospitalized healthcare workers were male, and 44.5% were female; their mean age was 41.41 years. However, in the general population, hospitalization rates were higher for women than for men (51.2% and 48.8%, respectively). Although the SARS‐CoV‐2 infectivity rate was higher in healthcare workers compared to the general population (68.6% vs. 56.1%), the mortality rate was significantly lower in them (1.7% vs. 3.8%). Fever, cough, Acute Respiratory Distress Syndrome, headache, and myalgia were the most prevalent symptoms in both groups. Among the cases examined in this study, inpatient ones aged 30–40 years and the general population aged over 60 seemed to be more likely to be hospitalized for Covid‐19. The hospitalization rate of healthcare workers during the pandemic follows the same pattern as the general population, but since the start of vaccination, this rate has decreased among healthcare workers compared to the general population of KB province.
Expanding the Strain‐Promoted 1,3‐Dipolar Cycloaddition Arsenal for a More Selective Bioorthogonal Labeling in Living Cells
Authors: Chinoy Zoeisha S. , Friscourt Frédéric 
Published: December 2022

AbstractThe advent of bioorthogonal chemistry, more importantly the strain‐promoted 1,3‐dipolar cycloaddition of cyclooctynes with azides to give stable triazoles, has opened new avenues for the study of biomolecules in their native environment. While much effort has been focused on improving the kinetics of these reactions, very little attention has been given to their bioselectivity. In this review, we will take you on our journey that led us to develop new cyclooctyne probes with enhanced physical attributes, including water solubility, cell‐surface labeling selectivity and fluorogenic capabilities. We then went on to expand the bioorthogonal chemistry toolbox by focusing on the development of new chemical reporters. Here you will read about our work investigating the use of other 1,3‐dipoles, including nitrile oxides and diazo reagents, for the labeling of biomolecules, and more recently highly biostable sydnones that can be exploited to selectively influence glycan‐processing enzymes.
Prevalence of intimate partner violence victimization among Korean perinatal women and associated factors
Authors: Lee Ji Yun , June Kyung Ja , Khang Young‐Ho , Kim Yu‐Mi , Cho Hong‐Jun 
Published: December 2022

AbstractObjectiveTo determine the prevalence of intimate partner violence (IPV) victimization and the factors associated with IPV during pregnancy and the early postnatal period in Korean community samples.MethodsWe enrolled 5953 pregnant mothers and mothers with young children registered in the Early Life Health Management Program provided by 30 public health centers in Korea between 2020 and 2021. We used the Korean Hurt, Insult, Threaten, and Scream (K‐HITS) questionnaire to measure IPV. Sociodemographic, social support, and psychosocial variables were collected using self‐administered questionnaires. χ2 tests and multiple logistic regression analyses were conducted using SAS.ResultsUsing a cut‐off score of 6 with K‐HITS, the prevalence of IPV was 7.6%. According to multivariable logistic analyses, “have seen domestic violence during childhood or adolescence” (odds ratio [OR] 2.61, 95% confidence interval [CI] 1.95–3.50), unplanned pregnancy (OR 2.18, 95% CI 1.73–2.75), depression during pregnancy (OR 2.17, 95% CI 1.69–2.79), history of receiving treatment for emotional problems (OR 1.53, 95% CI 1.07–2.20), and living in a rural area (OR 1.52, 95% CI 1.01–2.29) increased the odds of IPV. “Having someone who talk to” was protective of IPV (for” “Not having someone to talk to”: OR 2.24, 95% CI 1.49–3.35).ConclusionsPolicies to prevent and address IPV during the perinatal period are urgently needed in Korea.
Abdominal and robotic sacrocolpopexy costs following implementation of enhanced recovery after surgery
Authors: Baker Mary V. , Teles Abrao Trad Ayssa , Tamhane Prajakta , Weaver Amy L. , Visscher Sue L. , Borah Bijan J. , Klingele Christopher J. , Gebhart John B. , Trabuco Emanuel C. 
Published: December 2022

AbstractObjectiveTo compare perioperative costs and morbidity between open and robotic sacrocolpopexy after implementation of enhanced recovery after surgery (ERAS) pathway.MethodsThe present retrospective cohort study of patients undergoing open or robotic sacrocolpopexy (January 1, 2014, through November 30, 2017) used an ERAS protocol with liposomal bupivacaine infiltration of laparotomy incisions. Primary outcomes were costs associated with index surgery and hospitalization, determined with Medicare cost‐to‐charge ratios and reimbursement rates and adjusted for variables expected to impact costs. Secondary outcomes included narcotic use, length of stay (LOS), and complications from index hospitalization to postoperative day 30.ResultsFor the total of 231 patients (open cohort, 90; robotic cohort, 141), the adjusted mean cost of robotic surgery was $3239 higher compared with open sacrocolpopexy (95% confidence interval [CI] $1331–$5147; P < 0.001). Rates were not significantly different for intraoperative complications (robotic, 4.3% [6/141]; open, 5.6% [5/90]; P = 0.754), 30‐day postoperative complications (robotic, 11.4% [16/141]; open, 16.7% [15/90]; P = 0.322), or readmissions (robotic, 5.7% [8/141]; open, 3.3% [3/90]; P = 0.535). The percentage of patients dismissed on postoperative day 1 was greater in the robotic group (89.4% [126/141] vs. 48.9% [44/90], P < 0.001).ConclusionsDecreased LOS associated with ERAS provided significant cost savings with open sacrocolpopexy versus robotic sacrocolpopexy without adverse impacts on perioperative complications or readmissions.
Tropisetron improved testicular inflammation in the streptozotocin‐induced diabetic rats: The role of toll‐like receptor 4 (TLR4) and mir146a
Authors: Naderi Roya , Pourheydar Bagher , Moslehi Azam 
Published: December 2022

AbstractAs a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes. Reproductive disorders are one of the diabetes‐induced chronic complications. The present study aimed to evaluate the effect of tropisetron on diabetes‐induced testicular inflammation, its signaling pathway, and mir146a. To this end, animals were assigned to the control, tropisetron, diabetes (DM), DM‐tropisetron, and DM‐glibenclamide groups. Streptozotocin (50 mg/kg) was intraperitoneally injected to provide diabetes. Tropisetron and glibenclamide were then administrated intraperitoneally for 2 weeks after diabetes induction. Testes histology, real‐time polymerase chain reaction, western blot analysis, ELISA, and immunohistochemistry assays were also performed. The finding revealed that tropisetron significantly improved diabetes‐induced testis damages, lowered TLR4, TRAF6, IRAK1, NF‐κB, and caspase3 protein expressions, and decreased TNF‐α and IL‐1 levels. Moreover, the mir146a expression declined following the tropisetron treatment. This study demonstrated that the significant role of tropisetron in lowering testicular inflammation and apoptosis might have been due to the inhibition of the TLR4/IRAK1/TRAF6 signaling pathway and thereby the attenuation of NF‐κB and caspase3 expression and inflammatory cytokines. Furthermore, the downregulation of mir146a, as an inflammatory microRNA interacting with TLR4, showed another pathway, through which tropisetron improved diabetes‐induced testicular injuries.
Adsorptive bubble separation method in the recovery of a biomolecule
Authors: Poddar Sourav , Khanam Jasmina , Pradhan Prasenjit 
Published: December 2022

AbstractThe present work aims to separate an amino acid (l‐phenylalanine) from a highly dilute aqueous solution by the ‘adsorptive bubble separation method’. Separation is based on the principle of adsorption at the interphase of the gas bubble and aqueous phase and subsequent amino acid extraction in the top layered nonaqueous phase. The operation was carried out in a long glass column with a comprehensive solvent chamber at the top. Design‐Expert software optimizes the process parameters, and the process involves three variables: gas (nitrogen) flow rate, extractant, and solvent quantity, which control responses, recovery percentage, and the ratio of enrichment. The design models are found to be significant. The maximum recovery of amino acid observed was 75.545% and the value of the enrichment ratio was 3.87. In addition, two models were generated by the software, which was statistically significant (P < 0.05). Therefore, this process is adopted as it is of straightforward construction, eco‐friendly, and less costly than other methods previously known to recover l‐phenylalanine from a dilute solution. © 2022 Society of Chemical Industry (SCI).
The pilot study of a blended learning module using porcine tongue for surgical simulation of double‐opposing Z‐plasty
Authors: Huang Hanyao , Zeng Ni , Yang Chao , Wang Yan , Zheng Qian , Shi Bing , Cheng Xu 
Published: December 2022

AbstractPurposeSimulation course serves as an efficient supplement to the experiential learning inside the operation room in surgical residency programs. Furlow double‐opposing Z‐plasty (DOZ) remains an important and challenging surgical technique in cleft palate repair, but the simulation is currently limited. This study aims to develop a blended learning module with low‐cost and easy‐to‐promote DOZ simulation.MethodsComparison among the common rodent experimental animals and the readily available porcine tongue was made to select the ideal animal for surgical simulation, with which a DOZ learning module was developed. Oral surgery residents were enrolled to attend the blended learning module. An after‐session questionnaire and a quiz were distributed to the participants to collect their feedback of the course perceptions and to assess their learning outcomes.ResultsThe porcine tongue had more advantages in simulating the human soft palate over the common experimental animals. The surgical procedure of DOZ could be well designed and simulated on the porcine tongue. The vast majority of the participant liked the learning module regarded it as beneficial for the comprehension if DOZ principles and procedures. With the help of the porcine tongue simulator, the blended learning module helped the participants grasp the designing principles of DOZ procedure and promote their associative learning.ConclusionsThe blended learning module incorporating the porcine tongue simulator can help oral surgery residents master the principles and procedures of DOZ palatoplasty.
Efficacy of immunotherapy with combination of cryotherapy and topical imiquimod for treatment of Kaposi sarcoma
Authors: Gu Lilly , Lin Erica , Liu Shuaitong , Yang Ning , Kurtansky Nicholas , Neumann Neil M. , Stoll Joseph , Lezcano Cecilia , Pulitzer Melissa , Noor Sarah , Markova Alina , Rossi Anthony , Dickson Mark A. , Deng Liang 
Published: December 2022

AbstractMultiple treatment modalities for Kaposi sarcoma (KS) have been reported, including chemotherapy, radiation therapy, surgical excision, electrochemotherapy, and cryotherapy. Common topical treatments include timolol, imiquimod, and alitretinoin. We searched our institutional database for patients with ICD‐9 or 10 codes for KS seen by a dermatologist with experience in KS management from July 1, 2004 to January 1, 2022. We screened patient charts to include patients who received combination therapy of cryotherapy followed by topical imiquimod three times a week for 2 months (n = 9). Patients were followed in the clinic every 3 months. Time to resolution was assessed by photographic evidence of resolution as determined by a dermatologist and corroborated with clinical documentation in patient charts. Median age (IQR) at KS diagnosis was 58 (27.5) years. All patients were male (n = 9, 100%). Majority were white (n = 7, 78%) and non‐Hispanic (n = 8, 89%). Five (56%) had classic KS, one (11%) had HIV‐associated KS, and three (33%) were HIV‐negative men who have sex with men. Median time to resolution was 30.5 weeks, with a median of two treatments. In our study, 93% (n = 42/45) of lesions and 89% (n = 8/9) of patients experienced complete resolution during a median (range) duration of follow‐up of 58 (13–209) weeks. Side effects were limited to pain during cryotherapy, occasional blister formation after cryotherapy, and mild inflammation due to imiquimod. No infections were observed. Combination therapy of cryotherapy and topical imiquimod may be an efficacious and comparatively low‐risk treatment for limited, cutaneous KS.
Ultralow‐Power Piezo‐Optomechanically Tuning on CMOS‐Compatible Integrated Silicon‐Hafnium‐Oxide Platform
Authors: Shen Jian , Fan Yuyan , Xu Zihan , Wu Liying , Wang Ying , Li Xiuyan , Gan Xuetao , Zhang Yong , Su Yikai 
Published: December 2022

AbstractPower consumption of photonic integrated circuits becomes a critical consideration. A new platform is proposed for ultralow‐power tuning in silicon photonics via piezo‐optomechanical coupling using hafnium‐oxide actuators. As an example of the potential of the platform, a tunable silicon‐hafnium‐oxide hybrid microring, where hafnium‐oxide film acts as an active optical and piezoelectric layer, is demonstrated. The hybrid microring is capable of linear bidirectional tuning with a wavelength tuning efficiency of 8.4 pm V−1 and a power efficiency of 0.12 nW pm−1. The estimated power consumption for tuning a free spectral range (FSR) in hybrid microring is 3.07 µW per FSR. The hybrid silicon‐hafnium‐oxide technology with complementary metal‐oxide‐semiconductor (CMOS) compatibility advances the field of ultralow‐power integrated photonic devices and can find applications in optical communications, computing, and spaces under cryogenic temperatures.
Facile Preparation and Improved Electrochemical Performance of Oxygen‐Enriched Porous Carbon Materials Based on Diacetal‐Containing Polybenzoxazine
Authors: Wang Hanwu , Wang Peng , Li Jiamin , Ran Qichao 
Published: December 2022

AbstractPorous oxygen‐doped carbon materials based on the copolymers of a diacetal‐type benzoxazine (ACE‐a) and melamine with different ratios are prepared by a facile template‐free method. The oxygen‐rich diacetal structure in ACE‐a allowed for a high oxygen content of 66.2% in surface in these porous carbon materials, and the degradation of the melamine at a high temperature gave an ideal pore structure with a specific surface area of 1383.9 m2 g−1 and a pore capacity of 0.748 cm3 g−1. The electrochemical performances are analyzed by Cyclic voltammetry (CV) and Galvanostatic charge‐discharge (GCD) tests, and the effects of melamine contents and electrolyte types are also investigated. The results suggested that this material possessed specific capacitance of 430 F g−1 in 0.5 M H2SO4 and 194 F g−1 in 6 M KOH (0.5 A g−1), respectively, and showed excellent charge‐discharge behavior and magnification characteristic. Moreover, the copolymerization reactions, crosslinking structures, and degradation process of the benzoxazine/melamine copolymers are studied by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis‐infrared spectrometry (TGA‐IR), respectively. This kind of oxygen‐enriched porous carbon material has a good applicative prospect in the field of supercapacitor.