bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motor recruitment pattern during the prone hip extension test: is hip extension initiated by the hip or the lumbar extensor muscles?
Authors: Kiseljak Dalibor , Medved Vladimir 
Published: June 2022

Background/Aims Prone hip extension motion pattern derives from the motor muscle firing pattern, and functional deficits are determined by comparing this pattern with a normal prone hip extension motion muscle recruitment pattern, defined more than 30 years ago by scientifically insufficient methods. The aim of this study was to examine the differences between electromyography recruitment onsets and orders of muscles participating in prone hip extension motion, and to determine whether there is a consistent and dominant motor pattern. Methods The sample consisted of 106 healthy participants. Onset times of semitendinosus, ipsilateral and contralateral erector spinae muscles were determined as 10% of the peak rectified amplitude of the electromyography signal for each of the 18 prone hip extension bilateral repetitions. These values were used to determine the recruitment order for each repetition, as well as to calculate the average ipsilateral and contralatral normalised onset times (ie relative times to firing of the semitendinosus muscle). The main analysis was performed using a one-way analysis of variance. The level of statistical significance was set at P<0.05. Results One-way analysis of variance revealed a significantly delayed onset of prone hip extension of the contralateral erector spinae muscles compared to the other muscles (F=7.02; P<0.001; Cohen's f=0.209). Muscle activation initiated by the semitendinosus and ipsilateral erector spinae muscles was the most common. Conclusions The ipsilateral erector spinae muscle contracts simultaneously with the semitendinosus muscle as a proximal stabiliser, enabling distal hip mobility. The use of the prone hip extension test in recognising dysfunction is limited to when the contralateral erector spinae muscle is initiated first during prone hip extension.
Incremental shuttle walking test to assess functional capacity in cardiac rehabilitation: a narrative review
Authors: Pepera Garyfallia , Sandercock Gavin RH 
Published: June 2022

Background/AimsLow functional capacity has been recognised to be the most important predictor of overall mortality compared to all other cardiovascular risk factors in patients with cardiovascular disease. Walk tests, such as the incremental shuttle walking test and the 6-Minute Walk Test, are used to assess functional capacity in patients, the effectiveness of a cardiac rehabilitation programme and the prognosis of cardiovascular diseases. The aim of this review was to provide a narrative review of the literature and identify the key features of the incremental shuttle walking test as a measure of functional capacity testing in cardiac rehabilitation patients.MethodsThe PubMed, MEDLINE, Elsevier and Google Scholar databases were searched for relevant scientific articles published up to March 2021 with no restriction on start day. The key words defined by researchers were ‘incremental shuttle walking test’, ‘exercise test’, ‘functional capacity’, ‘cardiovascular disease’, ‘cardiac rehabilitation’, ‘reliability’ ‘prediction; ‘walk tests’. A final set of 31 articles was included in this narrative review.ResultsEvidence-based findings suggest that the incremental shuttle walking test is a valid, reliable, sensitive, useful tool for detecting and predict cardiorespiratory capacity.ConclusionsClinicians can be confident that they can use the incremental shuttle walking test to monitor changes in functional capacity in patients with cardiovascular disease.
Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis
Authors: Bai Na , Liu Wei , Xiang Tao , Zhou Qiang , Pu Jun , Zhao Jing , Luo Danyang , Liu Xindong , Liu Hua 
Published: June 2022

Background
Ischemic stroke (IS) is a complex polygenic disease with a strong genetic background. The relationship between the ANRIL (antisense non-coding RNA in the INK4 locus) in chromosome 9p21 region and IS has been reported across populations worldwide; however, these studies have yielded inconsistent results. The aim of this study is to clarify the types of single-nucleotide polymorphisms on the ANRIL locus associated with susceptibility to IS using meta-analysis and comprehensively assess the strength of the association.

Methods
Relevant studies were identified by comprehensive and systematic literature searches. The quality of each study was assessed using the Newcastle-Ottawa Scale. Allele and genotype frequencies were extracted from each of the included studies. Odds ratios with corresponding 95% confidence intervals of combined analyses were calculated under three genetic models (allele frequency comparison, dominant model, and recessive model) using a random-effects or fixed-effects model. Heterogeneity was tested using the chi-square test based on the Cochran Q statistic and I2 metric, and subgroup analyses and a meta-regression model were used to explore sources of heterogeneity. The correction for multiple testing used the false discovery rate method proposed by Benjamini and Hochberg. The assessment of publication bias employed funnel plots and Egger’s test.

Results
We identified 25 studies (15 SNPs, involving a total of 11,527 cases and 12,216 controls maximum) and performed a meta-analysis. Eight SNPs (rs10757274, rs10757278, rs2383206, rs1333040, rs1333049, rs1537378, rs4977574, and rs1004638) in ANRIL were significantly associated with IS risk. Six of these SNPs (rs10757274, rs10757278, rs2383206, rs1333040, rs1537378, and rs4977574) had a significant relationship to the large artery atherosclerosis subtype of IS. Two SNPs (rs2383206 and rs4977574) were associated with IS mainly in Asians, and three SNPs (rs10757274, rs1333040, and rs1333049) were associated with susceptibility to IS mainly in Caucasians. Sensitivity analyses confirmed the reliability of the original results. Ethnicity and individual studies may be the main sources of heterogeneity in ANRIL.

Conclusions
Our results suggest that some single-nucleotide polymorphisms on the ANRIL locus may be associated with IS risk. Future studies with larger sample numbers are necessary to confirm this result. Additional functional analyses of causal effects of these polymorphisms on IS subtypes are also essential.
Weight gain after renal transplant: Incidence, risk factors, and outcomes
Authors: Altheaby Abdulrahman , Alajlan Nuha , Shaheen Mohammed F. , Abosamah Ghaleb , Ghallab Basma , Aldawsari Basayl , Rashidi Awatif , Gafar Mohammed , Arabi Ziad 
Published: June 2022

Background
Renal transplantation is the definitive treatment for patients with end-stage renal disease (ESRD). It is associated with better quality of life and patient survival. Nevertheless, these benefits come with rising concerns about weight gain and metabolic abnormalities, which adversely impact transplant outcomes.

Objective
The objective of this study is to estimate the incidence of weight gain in the first year post-renal transplant in addition to the assessment of potential risk factors and the resulting outcome of the graft.

Methods
We conducted a single-center retrospective cohort study of all 295 patients who underwent kidney transplantation at King Abdulaziz Medical City (KAMC) between January 2016 and December 2019. Clinical and laboratory variables were collected from electronic records. Continuous variables were reported as mean ± standard deviation. Comparison between groups was assessed by unpaired t-test or Mann-Whitney U test while follow-up data were compared using paired t-test and repeated measures ANOVA. Association between the potential risk factors and the weight gain was assessed by means of binary logistic regression analysis.

Results
Significant weight gain was observed in 161 (54.6%) patients. Females were 119 (40.30%) of the cohort. The mean age was 45.3±15.1 years. The prevalence of diabetes was 234 (79.6%), while hypertensives constituted 77 (26.3%). The comparison between patients who gained weight significantly and patients with stable weight showed a numerical higher prevalence of female gender in patients who had more weight gain (44.1% vs. 35.8%), higher diabetes, higher rate of a living donor, and statistically significant lower dialysis duration before transplant. Other clinical and laboratory variables were comparable between the two groups.

Conclusion
Our study showed a high incidence of clinically significant weight gain among patients post-renal transplantation. Patients with lower dialysis duration, a living kidney donor and those who are obese at baseline were at higher risk of gaining weight. Patients who underwent kidney transplantation should be monitored closely for weight gain and further studies are needed to determine the risk factors and appropriate interventions.
Associations between Chinese college students’ anxiety and depression: A chain mediation analysis
Authors: Wen Li-ying , Shi Liu-xia , Zhu Li-jun , Zhou Meng-jie , Hua Long , Jin Yue-long , Chang Wei-wei 
Published: June 2022

Objective
Anxiety and depression are great public health concerns among college students. The purpose of this study was to explore whether sleep quality and quality of life (QoL) play mediating roles in anxiety and depression among Chinese college students.

Method
A total of 2757 college students (mean age = 19.07; SD = 1.14) completed the questionnaires, including a brief demographic survey. The 2-item General Anxiety Disorder (GAD-2) and the 2-item Patient Health Questionnaire (PHQ-2) were used to assess the symptoms of anxiety and depression, respectively. And the Pittsburgh Sleep Quality Index (PSQI) and the Short-Form 36 Health Survey (SF-36) were used to evaluate college students’ sleep quality and QoL, respectively. Mediation analyses were conducted by using PROCESS macro in the SPSS software.

Result
Anxiety had both direct and indirect effects on depression. Sleep quality and QoL were not only independent mediators in the relationship between anxiety and depression but also chain mediators.

Conclusion
The results of the current study highlight the crucial role of early intervention for depression with a focus on college students with anxiety, more especially, on those with poorer sleep quality and lower QoL.
Levodopa ONOFF-state freezing of gait: Defining the gait and non-motor phenotype
Authors: Landes Reid D. , Glover Aliyah , Pillai Lakshmi , Doerhoff Shannon , Virmani Tuhin 
Published: June 2022

Background
Freezing in the levodopa-medicated-state (ON-state) is a debilitating feature of Parkinson’s disease without treatment options. Studies detailing the distinguishing features between people with freezing of gait that improves with levodopa and those whose freezing continues even on levodopa are lacking.

Objective
To characterize the gross motor, gait, and non-motor features of this phenotype.

Methods
Instrumented continuous gait was collected in the levodopa-medicated-state in 105 patients: 43 non-freezers (no-FOG), 36 with freezing only OFF-levodopa (OFF-FOG) and 26 with freezing both ON- and OFF-levodopa (ONOFF-FOG). Evaluation of motor and non-motor disease features was undertaken using validated scales. A linear mixed model with age, sex, disease duration, and motor UPDRS scores as covariates was used to determine differences in spatiotemporal gait and non-motor disease features among the groups.

Results
Compared to OFF-FOG, the ONOFF-FOG group had greater disease severity (on the Unified Parkinson’s disease Rating Scale) and worse cognition (on the Montreal Cognitive Assessment, Frontal Assessment Battery and Scales for Outcome in Parkinson’s disease-Cognition scales) and quality of life (on the PDQ-39), but similar mood (on the Hamilton depression and anxiety scales) and sleep quality (on Epworth sleepiness scale and RBD questionnaire). For several gait features, differences between the ONOFF-OFF groups were at least as large and in the opposite direction as differences between OFF-no groups, controlling for disease severity. Variability in ONOFF-FOG was greater than in other groups. Using results from our study and others, a power analysis for a potential future study reveals sample sizes of at least 80 ONOFF and 80 OFF-FOG patients would be needed to detect clinically meaningful differences.

Conclusions
Intra-patient variability in spatiotemporal gait features was much greater in ONOFF-FOG than in the other two groups. Our results suggest that multifactorial deficits may lead to ONOFF-FOG development.
Experiences of COVID-19 infection in North Carolina: A qualitative analysis
Authors: Seidenfeld Justine , Tupetz Anna , Fiorino Cassandra , Limkakeng Alexander , Silva Lincoln , Staton Catherine , Vissoci Joao R. N. , Purakal John 
Published: June 2022

Background and aimIt has been demonstrated that marginalized populations across the U.S. have suffered a disproportionate burden of the coronavirus disease 2019 (COVID-19) pandemic, illustrating the role that social determinants of health play in health outcomes. To better understand how these vulnerable and high-risk populations have experienced the pandemic, we conducted a qualitative study to better understand their experiences from diagnosis through recovery.MethodsWe conducted a qualitative study of patients in a North Carolina healthcare system’s registry who tested positive for COVID-19 from March 2020 through February 2021, identified from population-dense outbreaks of COVID-19 (hotspots). We conducted semi-structured phone interviews in English or Spanish, based on patient preference, with trained bilingual study personnel. Each interview was evaluated using a combination of deductive and inductive content analysis to determine prevalent themes related to COVID-19 knowledge, diagnosis, disease experience, and long-term impacts.FindingsThe 10 patients interviewed from our COVID-19 hotspot clusters were of equal distribution by sex, predominantly Black (70%), aged 22–70 years (IQR 45–62 years), and more frequently publicly insured (50% Medicaid/Medicare, vs 30% uninsured, vs 20% private insurance). Major themes identified included prior knowledge of COVID-19 and patient perceptions of their personal risk, the testing process in numerous settings, the process of quarantining at home after a positive diagnosis, the experience of receiving medical care during their illness, and difficulties with long-term recovery.DiscussionOur findings suggest areas for targeted interventions to reduce COVID-19 transmission in these high-risk communities, as well as improve the patient experience throughout the COVID-19 illness course.
The risk of preterm birth in women with uterine fibroids: A systematic review and meta-analysis
Authors: Landman Anadeijda J. E. M. C. , Don Emma E. , Vissers Guus , Ket Hans C. J. , Oudijk Martijn A. , de Groot Christianne J. M. , Huirne Judith A. F. , de Boer Marjon A. 
Published: June 2022

Background
Fibroids have been identified as a possible risk factor for preterm birth, however, the magnitude of this risk is unclear. Our objective was to determine the risk of total, spontaneous, and medically indicated preterm birth in women with fibroids.

Methods
A literature search was performed on 9 June 2021. We selected studies reporting on preterm birth in women with and without fibroids. Fibroids had to be diagnosed by routine ultrasound before or during pregnancy. Main outcomes were total preterm birth <37, <34, <32, and <28 weeks of gestation, and spontaneous and medically indicated preterm birth. Two authors independently performed study selection, data extraction and quality assessment. We performed quality assessment with the Newcastle-Ottawa scale. Meta-analyses were presented as Odds Ratios (ORs) with 95% Confidence Intervals (95%CIs).

Main results
The search yielded 2078 unique articles of which 11 were included. Meta-analysis for preterm birth <37 weeks of gestation included 256,650 singleton deliveries: 12,309 with fibroids and 244,341 without fibroids. Women with fibroids had a higher rate of preterm birth (11.6% versus 9.0%; OR 1.66, 95%CI 1.29–2.14). Fibroids were also associated with preterm birth <34 (OR 1.88, 95%CI 1.34–2.65), <32 (OR 2.03, 95%CI 1.40–2.95) and <28 (OR 2.24, 95%CI 1.45–3.47) weeks of gestation. Data on type of preterm birth was limited: one study showed a significant association of fibroids with spontaneous preterm birth and another with indicated preterm birth. The main limitations of the included studies were the lack of correction for confounders, the risk of ascertainment bias due to possible underreporting of fibroids, and the substantial heterogeneity between studies.

Conclusions
Our results suggest fibroids are associated with an increased risk of preterm birth, with a stronger risk at earlier gestational ages. We encourage further research to clarify the association between fibroids and preterm birth by systematic myometrial assessment in pregnancy.

Registration
Prospero database [CRD42020186976].
Argonautes kai Syntrofoi: Opseis you Logotechnikou Pediou sti Dekaetia tou ‘30 (‘Argonauts and companions: Aspects of the literary field in the 1930s’), Christina Dounia (2021)
Authors: Antonelaki Fiona 
Published: June 2022

Review of: Argonautes kai Syntrofoi: Opseis you Logotechnikou Pediou sti Dekaetia tou ‘30 (‘Argonauts and companions: Aspects of the literary field in the 1930s’), Christina Dounia (2021)
Athens: Estia, 408 pp.,
ISBN 978-9-60051-804-7, p/bk, €19.00
Inter–Esse: Themata kai Ermineutikes Proseggiseis sti Neoelliniki Logotehnia (‘Inter–Esse: Themes and interpretative approaches to modern Greek literature’), Sophia Iakovidou (2020)
Authors: Markopoulou Athina 
Published: June 2022

Review of: Inter–Esse: Themata kai Ermineutikes Proseggiseis sti Neoelliniki Logotehnia (‘Inter–Esse: Themes and interpretative approaches to modern Greek literature’), Sophia Iakovidou (2020)
Athens: Gutenberg, 451 pp.,
ISBN 978-9-60012-148-3, p/bk, €23.00
STATISTICAL ANALYSIS OF RURAL POVERTY FACTORS IN THE RUSSIAN FEDERATION
Authors: Grigorieva E. G. , Shilova E. V. , Stakutis S. Z. 
Published: June 2022

The article presents the results of a correlation analysis of the ratio and dynamics of poverty in the constituent entities of the Russian Federation. The methodological foundations of the study are presented as a review of Russian and foreign studies of the ratio and reasons of poverty. We proposed the classification of the Russian constituent entities by the ratio of urbanization and conducted the two-dimensional grouping of constituent entities with an average ratio of urbanization by the ratio of poverty in 2019. The results of this study confirm the spread of poverty in rural areas and a high level of differentiation of constituent entities by poverty indicators.
Multiple correlation analysis allowed us to estimated models of multiple regressions and identifies significant independent variables of the ratio and dynamics of poverty in constituent entities with an average ratio of urbanization. It is concluded that the poverty ratio is lower in those constituent entities where tourism, manufacturing, animal husbandry, individual entrepreneurship, higher education and postgraduate studies are better developed. But poverty reduction is more successful in those constituent entities where trade, transport and warehousing logistics are developing.
In general, the study confirms the need to take into consideration specific regional features of the development of Russian constituent entities in the fight against poverty, the use of a targeted integrated approach in the selection of measures to reduce poverty.
STRATEGIC PLANNING TRENDS IN THE REGIONS (ON THE EXAMPLE OF THE ALTAI TERRITORY)
Authors: Sannikova I. N. , Borisova D. E. , Krayushkin M. G. 
Published: June 2022

The article contains the features of regional strategic planning in the context of the implementation of the national priority — people-saving. The purpose of the study is to determine the key vector of regional strategic planning, taking into account current trends and realities of the pandemic. The study is based on official data from the Federal State Statistics Service. The basis of the research methodology is a logical-epistemological toolkit with a linkage of general scientific methods of comparison and correlation analysis. It was found that the mortality rate of the population is of critical importance in achieving national strategic priorities. And, consequently, the identification of factors of an increased mortality rate is a priority analytical task in the implementation of a regional strategy of socio-economic development.
The results of the studies carried out provide the initial basis for the development of municipal strategies. In order to concretize targeted management decisions, it is further necessary to determine the relationship between mortality from specific diseases and the availability of doctors in the relevant specialties, with access to the schemes of targeted training of doctors for municipalities. More ambitious further tasks — to identify factors and assess the strength of their influence on the mortality of the population; to create an integrated model using Data Mining tools, which provides support for making management decisions aimed at reducing mortality in the region.
Aktifitas Antibakteri Isolat Bakteri Asam Laktat Saluran Pencernaan Kuda Laut (Hippocampus kuda Bleeker, 1852) Terhadap Vibrio harveyi
Authors: Sandi Fionica May , Subagiyo Subagiyo 
Published: June 2022

Seahorses (Hippocampus kuda) have high economic value in global trade. Therefore, to meet market demand, cultivation efforts have been carried out. Vibriosis caused by Vibrio harveyi is a disease that is often reported to affect seahorses. In this study, lactic acid bacteria were isolated from the digestive tract of seahorses, and were selected based on their antibacterial activity against V, harveyi. Antibacterial activity test was carried out by agar diffusion method. Isolates with antibacterial activity were identified based on their morphological and biochemical characteristics. The results of this study obtained 3 (three) LAB isolates that were active against V. harveyi from a total of 45 isolates, namely SPKL 34, SPKL 08 and SPKL 58. The SPKL 34 isolate had the highest antibacterial activity. The three isolates were identified as lactobacillus sp Kuda laut (Hippocampus kuda) memiliki nilai ekonomi tinggi sebagai salah satu jenis komoditas perdagangan global. Oleh karena itu untuk memenuhi permintaan pasar diantaranya telah dilakukan upaya budidaya. Vibriosis yang disebabkan oleh Vibrio harveyi merupakan penyakit yang sering dilaporkan menyerang Kuda Laut. Pada penelitian telah dilakukan pencarian jenis-jenis bakteri asam laktat (BAL) yang berasal dari saluran pencernaan Kuda Laut yang memiliki aktivitas antibakteri terhadap V. harveyi. Uji aktivitas antibakteri dilakukan dengan metode difusi agar. Isolat yang memiliki aktivitas antibakteri diidentifikasi berdasarkan karakteristik morfologi dan biokimia. Hasil penelitian ini memperoleh 3 (tiga) isolat BAL yang aktif terhadap V. harveyi dari total 45 isolat yaitu SPKL 34, SPKL 08 dan SPKL 58. Isolat SPKL 34 memiliki aktivitas yang paling tinggi yaitu dengan rerata luas zona hambat sebesar 4,14±0,60 mm. Hasil identifikasi menunjukkan ketiga isolat merupakan Lactobacillus sp. dengan tingkat kemiripan >80%.