bluuebunny/crossref_metadata_2025_split huggingface dataset:
Halophytes play important role in phytoremediation of salt-affected soils in the bed of Urmia Lake, Iran
Authors: Ahmadi Fatemeh , Mohammadkhani Nayer , Servati Moslem 
Published: July 2022

AbstractSoil salinity is a major threat in agriculture even in semi-arid regions of the world which can accelerate land degradation and desertification and decrease agricultural productivity and consequently jeopardize environmental and food security. Halophytes play important role in phytoremediation. This study is assessed the potential of Halocnemum strobilaceous, Atriplex verruciferae, Salsola crassae, and Salicornia europaeae in phytoremediation of saline soils occurred after water level desiccation of Urmia Lake. Three distances from the water body (500, 1000, and 1500 m) was selected for evaluating. Soils and plants were analyzed using standard methods. The mean values of salinity indices of the saline-sodic soil samples were identified as pH 8.6 and electrical conductivity (ECe) 65.34 dS m−1, also sodium adsorption ratio (SAR), and exchangeable sodium percentage (ESP) were higher than 13 and 15%, respectively. The maximum soil exchangeable Na+, K+, and Ca2+ concentrations (7200, 1900, and 1400 mg kg−1, respectively), also the concentrations of Mn2+ (12.5 mg kg−1), Fe2+ (5.5 mg kg−1), and Cu2+ (1.5 mg kg−1), were significantly different at various distances. However, the highest amounts were obtained at 500 m. In addition the concentration of Fe2+ (511.85 mg kg−1), Zn2+ (99.97 mg kg−1), and Na+ (25.65 mg kg−1) was the highest, especially in shoots. Furthermore, Salicornia and Halocnemum were more effective in salinity-remediation in comparison to other halophytes. The maximum dry matter (38%), protein (16%), and oil percentage (3.5%) were found in Salicornia, followed by Halocnemum. The findings indicated that salt-accumulating halophytes could be considered as the suggestions for phytoremediation saline soils and desalinating soil in arid and semi-arid regions.
Local retention efficacy of steroid-loaded PLGA microspheres in epidural injection
Authors: Jang Sowon , Cho Jungheum , Lee Eugene , Kang Yusuhn , Kang Myung Joo , Choi Young Wook , Lee Joon Woo 
Published: July 2022

AbstractLong-term effects of epidural steroid injections for pain management require novel drug formulations that increase tissue retention time. Present study aimed to investigate the local retention of steroid-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres in epidural injection using a rabbit model. Twenty rabbits were randomly assigned to a PLGA group (n = 10) and a triamcinolone acetonide (TA) group (n = 10). Each animal was injected with either TA-loaded PLGA microspheres or conventional TA suspension into the lumbar epidural space. The lumbar segments were then harvested from the sacrificed rabbits on day 1, week 1, 2, and 4 after the injection. On day 1, the residual steroid concentration (RSC) was lower in the PLGA group than in the TA group (5.03 ppm vs. 13.01 ppm). However, after a week, more steroids remained in the PLGA group (3.29 ppm vs. 0.58 ppm). After 2 weeks, fewer steroids remained in the PLGA group than in the TA group, although both contained less than 10% of the initial retention dose. This study shows that steroid-loaded PLGA tended to have higher steroid retention in tissue than the steroid itself at the first week after epidural injection. However, most of the steroids disappeared after 2 weeks in both groups.
Cerebral small vessel disease as imaging biomarker predicting ocular cranial nerve palsy of presumed ischemic origin at admission
Authors: Kang Dong-Wan , Ha Sue Young , Sung Jung-Joon , Nam Hyunwoo 
Published: July 2022

AbstractOcular cranial nerve palsy of presumed ischemic origin (OCNPi) is the most common type of ocular cranial nerve palsy (OCNP) in patients aged ≥ 50 years; however, no definite diagnostic test exists. As diagnostic criteria include clinical improvement, diagnoses are often delayed. Diagnostic biomarkers for OCNPi are required; we hypothesized that cerebral small vessel disease is associated with OCNPi. We analyzed 646 consecutive patients aged ≥ 50 years with isolated unilateral OCNP who underwent work-ups at two referral hospitals. White matter hyperintensities (WMHs), silent infarctions, and cerebral microbleeds (CMBs) were assessed. In multivariate analyses, mild (grades 1–3) and moderate to severe (grades 4–6) WMHs were significantly associated with OCNPi compared to OCNP of other origins (odds ratio [OR] 3.51, 95% confidence interval [CI] 1.91–6.43, P < 0.001; OR 3.47, 95% CI 1.42–8.48, P = 0.006, respectively). Silent infarction and CMBs did not remain associated (OR 0.96, 95% CI 0.54–1.70, P = 0.870; OR 0.55, 95% CI 0.28–1.08, P = 0.080, respectively). Associations between WMH and OCNPi remained after excluding patients with vascular risk factors. In conclusion, the presence of WMH could independently predict ischemic origin in patients with isolated unilateral OCNP at early stage of admission.
Ubiquitin carboxyl-terminal esterase L1 is not elevated in the serum of concussed rugby players: an observational cross-sectional study
Authors: Harrell Jazmin O. , Morgan Jessica E. , Beck Steven D. , Scobercea Iustin C. , Baker Julien S. , Knox Allan , Serrador Jorge M. , Rogatzki Matthew J. 
Published: July 2022

AbstractConcussion diagnosis is complicated by a lack of objective measures. Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is a biomarker that has been shown to increase following traumatic brain injury but has not been investigated in concussed athletes on the sideline of athletic events. Therefore, this study was conducted to determine if UCHL1 can be used to aid in sideline concussion diagnosis. Blood was taken via standard venipuncture from a recreationally active control group, a group of rugby players prior to match play (pre-match), rugby players following match-play (match-control), and rugby players after suffering a sport-related concussion (SRC). UCHL1 was not significantly different among groups (p > 0.05) and was unable to distinguish between SRC and controls (AUROC < 0.400, p > 0.05). However, when sex-matched data were used, it was found that the female match-control group had a significantly higher serum UCHL1 concentration than the pre-match group (p = 0.041). Differences were also found in serum UCHL1 concentrations between male and female athletes in the match-control group (p = 0.007). This study does not provide evidence supporting the use of UCHL1 in sideline concussion diagnosis when blood is collected soon after concussion but does show differences in serum UCHL1 accumulation between males and females.
A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders
Authors: Adewuyi Emmanuel O. , O’Brien Eleanor K. , Nyholt Dale R. , Porter Tenielle , Laws Simon M. 
Published: July 2022

AbstractConsistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer’s disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse several genome-wide association studies (GWAS) summary statistics (N = 34,652–456,327), to assess the relationship of AD with GIT disorders. Findings reveal a positive significant genetic overlap and correlation between AD and gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), gastritis-duodenitis, irritable bowel syndrome and diverticulosis, but not inflammatory bowel disease. Cross-trait meta-analysis identifies several loci (Pmeta-analysis < 5 × 10−8) shared by AD and GIT disorders (GERD and PUD) includingPDE4B,BRINP3,ATG16L1,SEMA3F,HLA-DRA,SCARA3,MTSS2,PHB, andTOMM40. Colocalization and gene-based analyses reinforce these loci. Pathway-based analyses demonstrate significant enrichment of lipid metabolism, autoimmunity, lipase inhibitors, PD-1 signalling, and statin mechanisms, among others, for AD and GIT traits. Our findings provide genetic insights into the gut-brain relationship, implicating shared but non-causal genetic susceptibility of GIT disorders with AD’s risk. Genes and biological pathways identified are potential targets for further investigation in AD, GIT disorders, and their comorbidity.
Cytoplasmic sequestration of p53 by lncRNA-CIRPILalleviates myocardial ischemia/reperfusion injury
Authors: Jiang Yuan , Yang Ying , Zhang Yang , Yang Jiqin , Zhang Man-man , Li Shangxuan , Xue Genlong , Li Xingda , Zhang Xiaofang , Yang Jiming , Huang Xiang , Huang Qihe , Shan Hongli , Lu Yanjie , Yang Baofeng , Pan Zhenwei 
Published: July 2022

AbstractMyocardial ischemia/reperfusion (MI/R) injury is a pathological process that seriously affects the health of patients with coronary artery disease. Long non-coding RNAs (lncRNAs) represents a new class of regulators of diverse biological processes and disease conditions, the study aims to discover the pivotal lncRNA in MI/R injury. The microarray screening identifies a down-regulated heart-enriched lncRNA-CIRPIL (Cardiac ischemia reperfusion associated p53 interacting lncRNA, lncCIRPIL) from the hearts of I/R mice. LncCIRPIL inhibits apoptosis of cultured cardiomyocytes exposed to anoxia/reoxygenation (A/R). Cardiac-specific transgenic overexpression of lncCIRPIL alleviates I/R injury in mice, while knockout of lncCIRPIL exacerbates cardiac I/R injury. LncCIRPIL locates in the cytoplasm and physically interacts with p53, which leads to the cytoplasmic sequestration and the acceleration of ubiquitin-mediated degradation of p53 triggered by E3 ligases CHIP, COP1 and MDM2. p53 overexpression abrogates the protective effects of lncCIRPIL. Notably, the human fragment of conserved lncCIRPIL mimics the protective effects of the full-length lncCIRPIL on cultured human AC16 cells. Collectively, lncCIRPIL exerts its cardioprotective action via sequestering p53 in the cytoplasm and facilitating its ubiquitin-mediated degradation. The study highlights a unique mechanism in p53 signal pathway and broadens our understanding of the molecular mechanisms of MI/R injury.
Striving Toward Equity in Health Care for People With Communication Disabilities
Authors: Morris Megan A. 
Published: July 2022

Purpose:
Approximately 10% of the U.S. adult population has a speech, language, and/or voice disability, collectively referred to as communication disabilities. An increasing number of studies demonstrate that persons with communication disabilities have worse health and health care outcomes as compared to those without communication disabilities. Understanding the state of the science, including potential contributing factors is critical to begin to address the disparities.

Method:
Applying a historical lens and integrating multiple models of disability provide a comprehensive perspective of the health and health care outcomes of persons with communication disabilities.

Results:
Three phases for addressing health care disparities exist: detecting, understanding, and reducing. Results from a 2012 National Health Interview Survey provide compelling population-level results of the health and health care disparities experienced by persons with communication disabilities. To understand the disparities, factors within the health care system, such as availability of communication aids and services, as well as provider and staff biases, assumptions, and lack of knowledge need to be considered. To date, few interventions exist to address disparities in care for persons with communication disabilities. Consequently, researchers need to engage with stakeholders in innovative study designs and methods to facilitate the rapid development, implementation, and dissemination of interventions that address the disparities.

Conclusion:
To ensure equity for the large and growing population of persons with communication disabilities, researchers, policy makers, patients, and health care systems need to collaborate in identifying and addressing the factors contributing to health and health care disparities.

Presentation Video:

https://doi.org/10.23641/asha.21215804
Multi‐view subspace clustering with incomplete graph information
Authors: He Xiaxia , Wang Boyue , Luo Cuicui , Gao Junbin , Hu Yongli , Yin Baocai 
Published: July 2022

AbstractThe core of multi‐view clustering is how to exploit the shared and specific information of multi‐view data properly. The data missing and incompleteness bring great challenges to multi‐view clustering. In this paper, we propose an innovative multi‐view subspace clustering method with incomplete graph information, so‐called incomplete multiple graphs clustering. Specifically, we creatively separate one shared and multiple specific graphs from multiple raw graph data, and exploit the mask fusion strategy and block diagonal regulariser to obtain the inherent category information. To handle the incomplete multiple graph data, we utilise multiple indicator matrices to mark the missing elements existed in each raw graph. In addition, the weight of each raw graph is adaptively learnt according to the graph importance. The alternative direction optimization algorithm is employed to solve our proposed methods. Finally, we also analyse the algorithm convergence and the computation complexity in detail. The clustering results on six real‐world datasets show that our method obviously outperforms a serious of classic incomplete multi‐view clustering methods.
A study of globular clusters in a lenticular galaxy in Hydra I from deep HST/ACS photometry
Authors: Hazra Nandini , Cantiello Michele , Raimondo Gabriella , Mirabile Marco , Blakeslee John P. , Branchesi Marica , Brocato Enzo 
Published: July 2022

Aims. We take advantage of exquisitely deep optical imaging data from the Hubble Space Telescope’s Advanced Camera for Surveys (HST/ACS) in the F475W (gF475W) and F606W (VF606W) bands to study the properties of the globular cluster (GC) population in the intermediate-mass lenticular galaxy PGC 087327in the Hydra I galaxy cluster.
Methods. We inspected the photometric (magnitudes and colour) and morphometric (compactness, elongation, etc.) properties of sources lying in an area of ∼19 × 19 kpc centred on PGC 087327 and compared them with four neighbouring fields over the same HST/ACS mosaic. This allowed us to identify a list of GC candidates and to inspect their properties using a background decontamination method.
Results. Relative to four comparison fields, PGC 087327 shows a robust overdensity of GCs, NGC = 82 ± 9. At the estimated magnitude of the galaxy, this number implies a specific frequency of SN = 1.8 ± 0.7. In spite of the short wavelength interval available with the gF475W and VF606W passbands, the colour distribution shows a clear bimodality with a blue peak at ⟨gF475W − VF606W⟩ = 0.47 ± 0.05 mag and a red peak at ⟨gF475W − VF606W⟩ = 0.62 ± 0.03 mag. We also observe the typical steeper slope of the radial distribution of red GCs relative to blue ones. Thanks to the unique depth of the available data, we characterise the GC luminosity function (GCLF) well beyond the expected GCLF turnover. We find
gTOMF475W = 26.54 ± 0.10
mag and
VTOMF606W = 26.08 ± 0.09
mag, which after calibration yields a distance of DGCLF = 56.7 ± 4.3(statistical) ± 5.2(systematic) Mpc.
Possible Alterations of Imaging Patterns in Computed Tomography for Delta-VOC of SARS-CoV-2
Authors: Yüksel Can , Sähn Marwin-Jonathan , Kleines Michael , Brokmann Jörg Christian , Kuhl Christiane K. , Truhn Daniel , Ritter Andreas , Isfort Peter , Schulze-Hagen Maximilian Franz 
Published: July 2022

Background So far, typical findings for COVID-19 in computed tomography (CT) have been described as bilateral, multifocal ground glass opacities (GGOs) and consolidations, as well as intralobular and interlobular septal thickening. On the contrary, round consolidations with the halo sign are considered uncommon and are typically found in fungal infections, such as invasive pulmonary aspergillosis. The authors recently observed several patients with COVID-19 pneumonia presenting with round, multifocal consolidations accompanied by a halo sign. As this may indicate alterations of CT morphology based on the virus variant, the aim of this study was to investigate this matter in more detail.
Methods 161 CT scans of patients with confirmed SARS-CoV-2 infection (RT-PCR within 2 days of CT) examined between January 2021 and September 15, 2021 were included. Follow-up examinations, patients with invasive ventilation at the time of CT, and patients with insufficient virus typing for variants of concern (VOC) were excluded. CT scans were assessed for vertical and axial distribution of pulmonary patterns, degree of involvement, uni- vs. bilaterality, reticulations, and other common findings. The mean density of representative lesions was assessed in Hounsfield units. Results were compared using Mann-Whitney U-tests, Studentʼs t-rests, descriptive statistics, and Fisher’s exact tests.
Results 75 patients did not meet the inclusion criteria. Therefore, 86/161 CT scans of unique patients were analyzed. PCR VOC testing confirmed manifestation of the Delta-VOC SARS-CoV-2 in 22 patients, 39 patients with Alpha-VOC and the remaining 25 patients with Non-VOC SARS-CoV-2 infections. Three patients with the Delta-VOC demonstrated multiple pulmonary masses or nodules with surrounding halo sign, whereas no patients with either Alpha-VOC (p = 0.043) or non-VOC (p = 0.095) demonstrated these findings. All three patients were admitted to normal wards and had no suspicion of a pulmonary co-infection. Patients with Delta-VOC were less likely to have ground glass opacities compared to Alpha-VOC (7/22 or 31.8 % vs. 4/39 or 10.3 %; p < 0.001), whereas a significant difference has not been observed between Delta-VOC and non-VOC (5/25 or 20 %; p = 0.348). The mean representative density of lesions did not show significant differences between the studied cohorts.
Conclusion In this study 3 out of 22 patients (13.6 %) with Delta-VOC presented with bilateral round pulmonary masses or nodules with surrounding halo signs, which has not been established as a notable imaging pattern in COVID-19 pneumonia yet. Compared to the other cohorts, a lesser percentage of patients with Delta-VOC presented with ground glass opacities. Based on these results Delta-VOC might cause a divergence in CT-morphologic phenotype.
Key Points:

Citation Format
Professional Standards in Medical Ultrasound – EFSUMB Position Paper (Short Version) – General Aspects
Authors: Wüstner Matthias , Radzina Maija , Calliada Fabrizio , Cantisani Vito , Havre Roald Flesland , Jenderka Klaus-Vitold , Kabaalioğlu Adnan , Kocian Milan , Kollmann Christian , Künzel Julian , Lim Adrian , Maconi Giovanni , Mitkov Vladimir , Popescu Alina , Saftoiu Adrian , Sidhu Paul S. , Jenssen Christian 
Published: July 2022

AbstractThis first position paper of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) on professional standards presents a common position across the different medical professions within EFSUMB regarding optimal standards for the performing and reporting of ultrasound examinations by any professional ultrasound operator. It describes general aspects of professionality that ensure procedure quality, effectiveness, efficiency, and sustainability in virtually all application fields of medical ultrasound. Recommendations are given related to safety and indication of ultrasound examinations, requirements for examination rooms, structured examination, systematic reporting of results, and management, communication and archiving of ultrasound data. The print version of this article is a short version. The long version is published online.
Comparative Evaluation of Diagnostic Quality in Native Low-dose CT without and with Spectral Shaping employing a Tin Filter in Urolithiasis with implanted Ureteral Stent
Authors: Axer Benedikt , Garbe Stephan , Hadizadeh Dariusch Reza 
Published: July 2022

Purpose Spectral shaping employing a tin filter can be used for dose reduction in CT of the abdomen in patients with urolithiasis. As ureteral stents may be in direct contact with the calculus, a good image quality is mandatory. The goal of this study was to obtain data of the effect of tin filtering on image quality and dose in patients with urolithiasis in direct contact with ureteral stents.
Materials and Methods 84 examinations (conventional low dose vs. modified low dose protocol with tin filtering, randomized) were performed in 65 patients (48 men, 17 women, age 55.0 ± 15.2 years (18–90 years), maximum of one examination per protocol). Image quality and visibility of the calculus was rated on a 5-point-Likert scale by 2 experienced radiologists. Quantitative indicators of image quality were signal-to-noise-(SNR) and contrast-to-noise-ratios (CNR) as well as a figure-of-merit (FOM).
Results With a non-inferiority margin of 0.5 points of the 5-point Likert scale, there was non-inferiority of the examinations with tin filter regarding image quality (95 % CI 4.1–4.3, rejection limit 3.5). Non-inferiority regarding visibility of the calculus could be shown (calculus size: 1–2.4 mm: 95 % CI 3.39–4.12; limit 2.73; 2.4–3.8mm: 95 % CI 4.09–4.47; limit 3.65; > 3.8mm: all maximal ratings). Average values of CNR were significantly higher using tin filters (17.0 vs. 10.6). Doses were significantly reduced in the modified protocol (effective dose 1.2 mSv vs. 1.5 mSv; size-specific dose estimate 2.33 mGy vs. 3.09 mGy) with non-significant effect in the subgroup of patients with BMI ≥ 35.
Conclusion Even with direct contact between a calculus and ureteral stent, radiation reduced examinations by spectral shaping by tin filters are non-inferior to examinations without tin filtering at a concurrent significant dose reduction.
Key points:
Citation Format
Professional Standards in Medical Ultrasound – EFSUMB Position Paper (Long Version) – General Aspects
Authors: Wüstner Matthias , Radzina Maija , Calliada Fabrizio , Cantisani Vito , Havre Roald Flesland , Jenderka Klaus-Vitold , Kabaalioğlu Adnan , Kocian Milan , Kollmann Christian , Künzel Julian , Lim Adrian , Maconi Giovanni , Mitkov Vladimir , Popescu Alina , Saftoiu Adrian , Sidhu Paul S. , Jenssen Christian 
Published: July 2022

AbstractThis first position paper of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) on professional standards presents a common position across the different medical professions within EFSUMB regarding optimal standards for the performing and reporting of ultrasound examinations by any professional ultrasound operator. It describes general aspects of professionality that ensure procedure quality, effectiveness, efficiency, and sustainability in virtually all application fields of medical ultrasound. Recommendations are given related to safety and indication of ultrasound examinations, requirements for examination rooms, structured examination, systematic reporting of results, and management, communication and archiving of ultrasound data. The print version of this article is a short version. The long version is published online.
Catalytic Hydrophosphination of Allenes Using an Iron(II) β-Diketiminate Complex
Authors: Webster Ruth L. , Woof Callum R. , Linford-Wood Thomas G. , Mahon Mary F. 
Published: July 2022

AbstractA rare study into the catalytic hydrophosphination of allenes is reported. Employing an Fe(II) β-diketiminate pre-catalyst, the reaction of HPPh2 proceeds with a range of aryl- and alkylallenes. For arylallenes the E-vinyl product forms as the major species, while the 1,1-disubstituted alkene is formed in a larger ratio than the Z-vinyl product (e.g., 6:3:1 as E/1,1/Z). The use of H2PPh results in good yields of the 1,1-disubstituted alkene, where the resultant secondary phosphine product does not undergo further reaction. We postulate a catalytic cycle based on spectroscopic data. Employing an [Fe(salen)]2-µ-oxo pre-catalyst leads to phosphine dehydrocoupling rather than hydrophosphination.