bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Model Pembelajaran Kooperatif Think Talk Write Terhadap Aktivitas Belajar Biologi Siswa SMA
Authors: Susanti Try , Simatupang Rita , Gusfarenie Dwi , Hidayat Rahmat 
Published: February 2022

Activities are very important principles in learning process. The teaching objectives of course will be achieved if students actively try to achieve them. Student activity in the learning process causes high interaction between teachers and students. The objective of this study is to understand the effect of the think talk write cooperative learning model on students activities in biology learning in SMA Negeri 2 Batanghari. This research is a quantitative study using true experimental-posttest only control design. The data collection instruments are observation sheets and documentation. Based on data analysis, it was obtained that the average of students learning activities from 3 meetings in the experiment class was 64.16%, the category active. While the average of student learning activities from 3 meetings in the control class was 37.70%, the category less active. Based on the calculation of the hypothesis test using the t-test, it was found that students learning activities obtained a value of t0 ≥ tt, namely 2.03 <4.31> 2.71, and the effect size of the treatment given was 1.43 with a percentage of 91.9% . It can be concluded that there is a significant influence on the use of the think talk write cooperative learning model on students activities in biology learning in SMA Negeri 2 Batanghari.
Abstrak. Aktivitas merupakan prinsip atau asas yang sangat penting dalam pembelajaran. Aktivitas siswa dalam proses pembelajaran menyebabkan interaksi yang tinggi antara guru dan siswa. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran kooperatif think talk write terhadap aktivitas belajar biologi siswa SMA Negeri 2 Batanghari. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain true experimental-posttest only control design. Instrumen pengumpulan data menggunakan lembar observasi dan dokumentasi. Berdasarkan analisis data diperoleh rata-rata aktivitas belajar siswa pada kelas eksperimen dari 3 kali pertemuan adalah 64,16% dengan kategori aktif. Sedangkan rata-rata aktivitas belajar siswa pada kelas kontrol dari 3 kali pertemuan adalah 37,70% dengan kategori kurang aktif. Berdasarkan perhitungan uji hipotesis menggunakan uji t, didapatkan bahwa aktivitas belajar siswa diperoleh nilai t0 ≥ tt yaitu 2,03 < 4,31 > 2,71, dan besar effect size perlakuan yang diberikan adalah 1,43 dengan persentase 91,9%. Hal tersebut dapat disimpulkan bahwa terdapat pengaruh yang signifikan dalam penggunaan model pembelajaran kooperatif think talk write terhadap aktivitas belajar biologi siswa SMA Negeri 2 Batanghari.
Heterogeneity of Type 1 Diabetes at Diagnosis Supports Existence of Age-Related Endotypes
Authors: Parviainen Anna , Härkönen Taina , Ilonen Jorma , But Anna , Knip Mikael ,   the Finnish Pediatric Diabetes Register
Published: February 2022

OBJECTIVE
Previous findings suggest that there are age-related endotypes of type 1 diabetes with different underlying etiopathological mechanisms in those diagnosed at age &lt;7 years compared with those diagnosed at age ≥13 years. We set out to explore whether variation in demographic, clinical, autoimmune, and genetic characteristics of children and adolescents with newly diagnosed type 1 diabetes support the existence of these proposed endotypes.

RESEARCH DESIGN AND METHODS
We used data from the Finnish Pediatric Diabetes Register to analyze characteristics of 6,015 children and adolescents diagnosed with type 1 diabetes between 2003 and 2019. We described and compared demographic data, clinical characteristics at diagnosis, autoantibody profiles, and HLA class II–associated disease risk between three groups formed based on age at diagnosis: &lt;7, 7–12, and ≥13 years.

RESULTS
We found significant age-related differences in most of the characteristics analyzed. Children diagnosed at age &lt;7 years were characterized by a higher prevalence of affected first-degree relatives, stronger HLA-conferred disease susceptibility, and higher number of autoantibodies at diagnosis, in particular a higher frequency of insulin autoantibodies, when compared with older children. Those diagnosed at age ≥13 years had a considerably higher male preponderance, higher frequency of glutamic acid decarboxylase autoantibodies, longer duration of symptoms before diagnosis, and more severe metabolic decompensation, reflected, for example, by a higher frequency of diabetic ketoacidosis.

CONCLUSIONS
Our findings suggest that the heterogeneity of type 1 diabetes is associated with the underlying disease process and support the existence of distinct endotypes of type 1 diabetes related to age at diagnosis.
Identifying Suicide Risk in Adolescents and Young Adults With Type 1 Diabetes: Are Depression Screeners Sufficient?
Authors: Moss Ashley C. , Roberts Alissa J. , Yi-Frazier Joyce P. , Read Kendra L. , Taplin Craig E. , Weaver Kathryn W. , Pihoker Catherine , Hirsch Irl B. , Malik Faisal S. 
Published: February 2022

OBJECTIVE
Examine the utility of suicide-risk items embedded within depression screeners for identifying the presence of suicide risk in adolescents and young adults (AYA) with type 1 diabetes.

RESEARCH DESIGN AND METHODS
Sensitivity, specificity, and predictive value of self-report of suicide risk on the Patient Health Questionniaire-9 (PHQ-9) were compared with the pediatric psychologist–administered Columbia-Suicide Severity Rating Scale (C-SSRS) as the reference standard for AYA with type 1 diabetes seen in a multidisciplinary AYA Diabetes Program clinic.

RESULTS
Of 133 participants, 9.8% and 11.3% reported suicide risk on the PHQ-9 and C-SSRS, respectively. Sensitivity of the PHQ-9 risk item was 53.3% (95% CI 27.4%–77.7%), specificity was 95.7% (95% CI 89.9%–98.4%), positive predictive value was 61.5% (95% CI 32.3%–84.9%), and negative predictive value was 94.2% (95% CI 87.9–97.4%).

CONCLUSIONS
Depression screeners appear to under-identify AYA with type 1 diabetes who may otherwise be at risk for suicide.
Ankle fractures in Finland: 118,929 operatively treated between 1987 and 2019
Authors: Happonen Ville , Kröger Heikki , Kuismin Markku , Sund Reijo 
Published: February 2022

Background and purpose: Ankle fractures are one of the most common fractures requiring operative treatment. They occur most commonly in postmenopausal women and younger men and recent studies suggest that the incidence of ankle fractures is increasing. In this registry study, we analyze inpatient data of operatively treated ankle fractures during a period of 33 years from our comprehensive nationwide register data.
Patients and methods: The data on operatively treated ankle fracture patients between January 1, 1987 and December 31, 2019 was collected from the Finnish National Hospital Discharge Register and analyzed.
Results: 118,929 ankle fractures were treated operatively. These included lateral malleolar fractures (33%), bior trimalleolar fractures (51%), medial malleolar fractures (7%), and other fractures (9%). Mean age was 53 (SD 17) years for women and 43 (16) for men. The average annual incidence rate was 69 per 100,000 person-years. Over the past 3 decades incidence has leveled off for women and hasstarted to decline for men. However, the incidence is increasing in the elderly women group (over 70 years of age). In the over 50 age group, comorbidities have increased over the years, being more common in men than in women. The incidence of ankle fractures was higher during the winter months (November–March).
Interpretation: The number of operatively treated ankle fractures has leveled off during the last 33 years. However, nowadays we operate on more difficult fractures in elderly patients with comorbidities.
Analysis of 5 Floors Brick Masonry Building Type 77/5
Authors: Koka Petraq , Vesho Nikolla , Shehu Fabion 
Published: February 2022

The study below presents the main results of numerical analyzes, performed to assess the seismic response of an existing building, with brick masonry, type 77/5. This building is part of the group of 4-5 residential buildings, built in the years 1975-1990, considered as a “TYPE”, each of which was used many times for identical buildings.
This project is the result of a collective work of the Design Institute, approved by the Ministry of Construction of that time, and of course, manifests the time limitations and shortcomings.
While these 5-story buildings cover a significant percentage of residential buildings, the fundamental question is: “Are these buildings safe under seismic action, while so many families are accommodated on them?”
This question stems from the following limitation:
- The 77/5 plan derives from regular forms, based on the recommendations of Eurocode 8 [4.2.3.2], p.48, and KTP.N.2-89 (Technical Design Conditions), published by the Academy of Sciences of Albania.
- The technical literature provides recommendations and restrictions for masonry buildings with a height of not more than 3 floors. When they exceed this height, they are not included in these recommendations.
The Neutrino Decay of the Free Neutron and the Neutrino Structure According to the Planck Vacuum Theory
Authors: Daywitt William C. 
Published: February 2022

The Planck vacuum (PV) theory derives equations for the neutrino and antineutrino, and relates them to the unstable free neutron and antineutron. Remarkably, these neu- trons and neutrinos share the same wavefunction solutions that describe the proton and electron and their antiparticle cores.
The neutrino and antineutrino are chargeless and massless; so their propagation through matter goes unnoticed, making these neutrinos invisible. The equations to follow that describe these pseudo-particles are the theoretical embodiment of the circa 1930 Pauli neutrino hypothesis.
Finally, depending on one’s perspective, the neutrons can be viewed as decaying meta-particles or as stable nuclear particles.
A Review of Multi-Channel Medium Access Control Protocols for Wireless Sensor Networks
Authors: Alahmadi Hanan , Boabdullah Fatma 
Published: February 2022

Wireless Sensor Networks (WSNs) are witnessing a momentum spread especially with the growth of the Internet of Things (IoT) paradigm. Indeed, WSNs are considered as the main enabling infrastructure for IoT networks. Nowadays, the emerging WSNs applications require not only long network lifespan but also considerably high data rate. Consequently, conceiving Multichannel MAC protocols that save the scarceenergy budget of sensor nodes while providing high network throughput is crucial for the emerging WSNs applications. In this paper, a thorough review of recent multichannel MAC protocols is provided along with a classification framework to deeply understand the design aspects for each protocol.
Stability of Underground Coal Mine Roadway Excavated in Soft Rock Mass
Authors: Pongpanya Phanthoudeth , Soysouvanh Vongsavanh , Sasaoka Takashi , Shimada Hideki 
Published: February 2022

This paper studies the stability and ground behavior of the main roadway excavated in a soft rock mass at PT Gerbang Daya Mandiri (GDM) underground coal mine in Indonesia. The stability and ground behavior of the main roadway under various geological and excavation conditions was analyzed and discussed through numerical simulations and field measurement data. Based on the results, it is found that the mechanical conditions of claystone and the geological conditions of the roof have an obvious impact on the stability of the main roadway. The large roof displacement of the roadway occurs when the roadway is excavated in the deteriorated claystone, whereas the small roof displacement occurs when the roadway excavation is made in the undeteriorated claystone and when the coal layer is present in the roof. Under undeteriorated conditions of claystone, the small failure zone and displacement of the roadway occur. The current support system using the steel arch SS400 is effective to control the roadway stability. As the claystone has deteriorated due to groundwater, the failure zone and displacement expand considerably, and the roadway stability decreases significantly. The use of the current support system (steel arch SS400) is difficult to control the stability of the main roadway. Under this situation, a stronger steel arch SS540 is recommended to apply. Furthermore, the presence of a coal layer during the excavation considerably improves the stability of the main roadway. Compared with the roadway excavated in claystone only, the displacement decreases significantly. In addition, by leaving a thicker coal layer in the roof, a better stability condition of the roadway can be achieved.
Design and Fabrication of Low-Cost Incubator to Evaluate Hatching Performance of Egg
Authors: Soeb Md. Janibul Alam , Al Mamun Muhammad Rashed , Shammi Shamima , Uddin Minhaj , Eimon Rukon Ahmed 
Published: February 2022

In this study, a poultry egg incubator was designed, fabricated, and tested to evaluate its hatching performance. The incubator consists of a microcontroller with egg turner trays and incubating chamber of 116 nos. of egg capacity. The hatchability of the developed incubator was 79.3% and 87.1% hatchability during manual and automatic trials respectively. The temperature in the developed incubator was within the acceptable incubation temperature ranges from 37.6 °C to 38.6 °C. The average relative humidity in the developed incubator was maintained at 63.6% at manual and 55-65% at automatic trial. The eggs were turned manually approximately at 6 hours of interval. On the other hand, in the automatically controlled trial, it was done by egg turner maintaining exactly 6 hours of interval. It is noted that the percentage of hatching in rice husk incubators is below 55% which is much below comparing with the developed incubator. Also, the newborn chickens in rice husk incubators are unhealthy as they don’t get a sufficient amount of heat. Besides, in the sand incubation technique, kerosene-based hurricane lamps are used which produce Carbon Dioxide. The developed incubator is environment friendly because it doesn’t produce any by-product that is responsible for harming the environment. Also, after the successful trials, we have found the benefit-cost ratio was 1.42 which was quite satisfactory. The egg incubator can maintain the optimum conditions for the hatching of the chicken eggs and is capable of incubating and hatching the chicken eggs effectively. If the developed incubator is commercially supplied to the end-user, it will be a beneficial process of hatching for the farmer of Bangladesh.
Tomato Yield and Quality Response to Water Application Technique and Management
Authors: Gashari Tom , Twaibu Semwogerere , Kucel Samuel Baker , Magumba David 
Published: February 2022

Tomato (Lycopersicon esculentum Mill) is one of the most important and has the highest acreage of any vegetable crop in the world. Such quantitative analysis is based on the assessment of data from sequential collections of plant traits linked to environmental conditions, as well as yield potential under optimal growth conditions. The objective in this study was to evaluate the performance of tomato crop under furrow, basin and hosepipe irrigation techniques in Kabos, Serere District of Eastern Uganda. The materials and methods used in this study included tools like water pump (model DCX2-50D), Tomato variety Rionex, weighting scale, CROPWAT 8.0 software, CANOPEO software among others. Generally, quantitative techniques through several experiment designs were used. Daily and monthly weather variables, in-situ primary datasets of plant height, canopy cover percentages and fruit characteristics, and weight of harvested tomatoes were measured at three growth stages and analyzed using RCBD experiment with six treatments and four replications.
Findings showed that overhead treatments had lowest rate of rotten yield compared to basin and furrow but had highest rate of discolored fruits attributed to sunshine and impact of water pressure during irrigation. Rotting of yield was highest in basin treatments. The rotting was attributed to water logging, poor drainage that accelerated fungal infection in the tomatoes. Furrow treatments had better drainage which reduced quantity of nonmarketable yield. There was no significant difference on the weight of tomatoes below 65g. This meant that fruit weight was independent of irrigation method. Treatments under hosepipe irrigation-overhead. Conclusively, water management practices have big impact on the crop yield giving a relationship that yield is directly proportional to water management practices, which however, should be followed by detailed soil and water analysis through such studies. The Safe-Water-for Food (SWFF) target can be reached and eventually reduce on the global hunger syndrome.
Effects of Microwave Radiation on Human Brain: The Positives and Negatives
Authors: Bhattacharya Ela , Mandal Mohanchandra , Bhattacharya Dipasri 
Published: February 2022

Several RF sources are present for the commercial as well as defense application. In this article we will focus on the neurological consequences of Microwave Radiation (MWR). Since microwaves impact so many facets of our lives, this research focuses on their health implications. The brain is perhaps the most sensitive organ to MWR, with mitochondrial damage manifesting faster and more profoundly than in other regions. The effects of MWR on brain metabolic pathways have piqued public attention. The possibility for significant numbers of people to be subjected to dynamic, multi-frequency microwave energy nowadays, is a reality. Many urban people residing in the highrise structures of the city, come in the main beam radiation of the antenna which is mounted at a comparable height. Owing to the pervasive presence of MWR, its extensive usage, and the potential for harmful effects, comprehensive analyses of the health risks are imperative. It is crucial, therefore, to assess the level of exposure that is safe for the general population so as to minimize adverse effects despite reducing the favorable uses of microwaves.
UPAYA IBU MEMPERBAIKI POLA KOMUNIKASI DALAM KELUARGA DI DESA SIOLIP KECAMATAN BARUMUN KABUPATEN PADANG LAWAS
Authors: Hasni Nasution Inayati , Sudirman Sudirman 
Published: February 2022

Masalah dalam penelitian ini adalah komunikasi antara ayah dan remaja putri yang tidak terjalin dengan baik, peran ibu yang cenderung tidak memfasilitasi komunikasi antara ayah dan remaja putri. Penelitian ini bertujuan untuk mendeskripsikan informasi tentang gambaran pola komunikasi yang terjalin antara ayah dan remaja putri dalam keluarga di desa Siolip, untuk mendeskripsikan peran ibu sebagai fasilitator komunikasi dalam keluarga di desa Siolip dan untuk mengetahui hasil pola komunikasi antara ayah dan remaja putri di desa Siolip. Jenis penelitian ini menggunakan Eksperimen dengan Disign penelitian Pre-tes dan Pos-test disign. Perlakuan yang diberikan berupa penyuluhan. Sampel yang diambil sebanyak 42 orang. Alat pengumpulan data yang digunakan adalah angket (kuesioner). Dan teknik analisis data menggunakan statistik deskriptif dan uji hipotesis (uji-t). Dari hasil rumus statistik deskriptif dan uji hipotesis (uji-t) diperoleh thitung = 41.496 sedangkan ttabel = 1.682, maka thitung = 41.496 > ttabel = 1.682. maka hipotesis diterima. Hal ini membuktikan bahwa terdapat perubahan Peran Ibu Sebagai Fasilitator Untuk Memperbaiki Pola Komunikasi Keluarga Di Desa Siolip Kecamatan Barumun Kabupaten Padang Lawas.
PENGARUH KOMUNIKASI ORANGTUA DENGAN ANAK TERHADAP KEPERCAYAAN DIRI ANAK USIA 4-5 TAHUN DI PAUD BUNDA DESA CEMPEDAK LOBANG KECAMATAN SEI RAMPAH
Authors: Ayu Lestari Diyah , Anifah Anifah 
Published: February 2022

Penelitian ini bertujuan untuk; 1) mengetahui komunikasi yang dilakukan orangtua terhadap anak dan 2) Mengetahui kondisi kepercayaan diri anak usia 4-5 Tahun di PAUD BUNDA Desa Cempedak Lobang Kecamatan Sei Rampah . Jenis penelitian deskriptif kuantitatif dengan jumlah sampel 70 orangtua murid (ayah/ibu) di kelas B1 dan B2 yang berada di PAUD BUNDA Desa Cempedak Lobang Kec. Sei Rampah. Hasil penelitian menunjukkan bahwa terdapat pengaruh langsung dan positip, variabel Komunikasi Organg Tua (X) berpengaruh langsung dan signifikan terhadap Kepercayaan Diri Anak Usia 4-5 Tahun dimana besar koefisien antara (X) dengan (Y) dan besarnya pengaruh Komunikasi Organg Tua (X) terhadap Kepercayaan Diri Anak Usia 4-5 Tahun adalah 0,0600. Artinya bahwa Komunikasi Organg Tua (X) secara langsung menentukan perubahan kepada Kepercayaan Diri Anak Usia 4-5 Tahun sebesar 6.%.
Cancer gene therapy goes viral: viral vector platforms come of age
Authors: Bezeljak Urban 
Published: February 2022

Abstract

Background
Since the advent of viral vector gene therapy in 1990s, cancer treatment with viral vectors promised to revolutionize the field of oncology. Notably, viral vectors offer a unique combination of efficient gene delivery and engagement of the immune system for anti-tumour response. Despite the early potential, viral vector-based cancer treatments are only recently making a big impact, most prominently as gene delivery devices in approved CAR-T cell therapies, cancer vaccines and targeted oncolytic therapeutics. To reach this broad spectrum of applications, a number of challenges have been overcome – from our understanding of cancer biology to vector design, manufacture and engineering. Here, we take an overview of viral vector usage in cancer therapy and discuss the latest advancements. We also consider production platforms that enable mainstream adoption of viral vectors for cancer gene therapy.

Conclusions
Viral vectors offer numerous opportunities in cancer therapy. Recent advances in vector production platforms open new avenues in safe and efficient viral therapeutic strategies, streamlining the transition from lab bench to bedside. As viral vectors come of age, they could become a standard tool in the cancer treatment arsenal.
Percutaneous electrochemotherapy in primary and secondary liver malignancies – local tumor control and impact on overall survival
Authors: Spallek Hannah , Bischoff Peter , Zhou Willi , de Terlizzi Francesca , Jakob Fabian , Kovàcs Attila 
Published: February 2022

Abstract

Background
Local nonsurgical tumor ablation currently represents a further option for the treatment of patients with liver tumors or metastases. Electrochemotherapy (ECT) is a welcome addition to the portfolio of local therapies. A retrospective analysis of patients with liver tumors or metastases treated with ECT is reported. Attention is given to the safety and efficacy of the treatment over time.

Patients and methods
Eighteen consecutive patients were recruited with measurable liver tumors of different histopatologic origins, mainly colorectal cancer, breast cancer, and hepatocellular cancer. They were treated with percutaneous ECT following the standard operating procedures (SOP) for ECT under general anaesthesia and muscle relaxation. Treatment planning was performed based on MRI preoperative images. The follow-up assessment included contrast-enhanced MR within at least 1–3 months after treatment and then after 5, 7, 9, 12, and 18 months until progression of the disease or death.

Results
Only mild or moderate side effects were observed after ECT. The objective response rate was 85.7% (complete response 61.9%, partial 23.8%), the mean progression-free survival (PFS) was 9.0 ± 8.2 months, and the overall survival (OS) was 11.3 ± 8.6 months. ECT performed best (PFS and OS) in lesions within 3 and 6 cm diameters (p = 0.0242, p = 0.0297)
.
The effectiveness of ECT was independent of the localization of the lesions: distant, close or adjacent to vital structures. Progression-free survival and overall survival were independent of the primary histology considered.

Conclusions
Electrochemotherapy provides an effective valuable option for the treatment of unresectable liver metastases not amenable to other ablative techniques.