bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eosinophilic meningitis following suboccipital craniotomy without bovine dural graft: illustrative case
Authors: Cho Woo Cheul , Lee Hyeong Jin , Lee Jung Koo , Choi Jai Ho 
Published: January 2022

BACKGROUND
Eosinophilic meningitis is a rare known complication after brain surgery associated with duraplasty using artificial bovine graft. However, eosinophilic meningitis after craniotomy without bovine dural graft has not been reported.

OBSERVATIONS
A 48-year-old female presented with lateral medullary infarction caused by a vertebral artery dissecting aneurysm incorporating the posterior inferior cerebellar artery (PICA). The authors performed occipital artery–PICA anastomosis and repaired the dura by primary suture without bovine graft. Thereafter, endovascular internal trapping using coils was conducted. Severe headache developed at postoperative day 17, and the patient was diagnosed with eosinophilic meningitis. After administration of a high-dose corticosteroid for 2 weeks, her symptoms and laboratory findings were improved.

LESSONS
Postoperative eosinophilic meningitis is rarely related to craniotomy without using bovine graft. Neurosurgeons should consider the possibility of eosinophilic meningitis after craniotomy without a xenogeneic dural material.
Criss-cross hemostatic suture in nephron sparing open surgery
Authors: Simonato Alchiede , Mirko Pinelli , Tulone Gabriele , Vella Marco , Giaimo Rosa , Mannone Piero , Baiamonte Davide , Pavan Nicola 
Published: January 2022

Surgery is the curative treatment for localized Renal Cancer Carcinoma (RCC). Nephron sparing surgery is the recommended treatment modality in patients with T1 tumors based on oncological and functional outcomes [1]. Patients with stage T1a renal cancer who have undergone conservative surgery have demonstrated better survival and functional outcomes [2]. Renorrhaphy and resection technique are important for the preservation of the renal function. To date no technique is clearly preferable, and the choice can be made based on preference and experience of the surgeon [5]. The criss-cross technique guarantees excellent haemostasis by limiting the insult on healthy renal parenchyma.
EFFICACY OF PHOTODYNAMIC THERAPY AS AN ADJUNCT TO NON – SURGICAL PERIODONTAL THERAPY IN TYPE-2 DIABETES MELLITUS PATIENT
Authors: Ghosh Roshni , Shukla Pradeep , Kataria Prerna , Shukla Preeti , Dagar Mona 
Published: January 2022

Background: To Evaluate the additional benefit of Antimicrobial Photodynamic therapy, if any in the glycemic control of type 2 diabetes mellitus chronic periodontitis patients .
Methods: Fifty diabetic patients with chronic periodontitis were taken for the study who met the inclusion criteria of clinical attachment loss ?3 to 5 mm at ? 30% of sites and bleeding on probing present in two different quadrants . After SRP ( Scaling and root planing ) , one quadrant was selected for aPDT while other served as a control group. Clinical parameters i.e. Plaque index, Probing depth ,Relative attachment level and HBA1c were measured at baseline, 1 week , 1month and 3 months.
Results: Statistically significant differences in the mean probing depth, Relative attachment level, plaque deposit, and HBA1c were found between baseline and 12 weeks post-treatment for both groups. No significant differences in glucose levels were detected among the two groups in 1 week . Reduction in the mean HbA1c level after treatment was observed in both groups in 1 month and 3 months .
Conclusion: Antimicrobial Photodynamic Therapy when used in addition to scaling and root planing yields significant improvement of mean probing depth , Plaque deposit ,Relative attachment levels, periodontal status and reduction of HbA1c levels in treatment of diabetic patients with periodontitis when comparing the test group to the control group.
Keywords: photodynamic therapy , scaling and root planing, glycated haemoglobin ,Randomized controlled trial
Oksidatif, Apoptotik ve İnflamatuar Sinyal Yolakları üzerinden C6 Glioblastoma Hücrelerindeki ML351'in Antiproliferatif Etkileri
Authors: HACIOĞLU Ceyhan , KAR Fatih 
Published: January 2022

Amaç: Kanser tedavisindeki başarılı yaklaşımlardan biri de spesifik inhibitörlerin kullanılmasıdır. Çoklu doymamış yağ asitlerinin metabolizmasından sorumlu olan 12/15-lipoksijenaz (12/15-LOX) nöronlarda oksidatif stres kaynaklanan hücre ölümüne aracılık etmesinin yanı sıra, kanser gibi birçok önemli hastalıkta yer alan metabolitlerin üretemini de gerçekleştirir. Bu çalışmada, 12/15-LOX inhibitörü olan ML351'in C6 glioblastoma hücrelerin üzerindeki anti-proliferatif etkilerini çeşitli biyokimyasal süreçler üzerinden araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Çalışmada önce C6 hücreleri için sitotoksik ML351 konsantrasyonları metil tiazolil tetrazolyum (MTT) kullanılarak tespit edilmiştir ve ardından total oksidan kapasite (TOS), sitokrom c (CYC), kaspaz 3 (CASP3), tümör nekroz faktör alfa (TNF-α) ve interlökin-6 (IL-6) seviyeleri ölçüldü.
Bulgular: Sonuç olarak, ML351 C6 hücreleri üzerinde konsantrasyon bağımlı anti-proliferatif etkilerinin olduğu görüldü. ML351 uygulamasının C6 hücrelerinde oksidatif strese neden olarak TOS seviyelerini artırdığı belirlendi. ML351 uygulanması kontrol grubu ile karşılaştırıldığında CASP3 ve CYC seviyelerini artırdı (p
Bipolar Bozukluk Hastalarında Çocukluk Çağı Travması ile Bilişsel Duygu Düzenleme ve Başa Çıkma Tutumları Arasındaki İlişki
Authors: TUMAN Taha Can , HURŞİTOĞLU Onur 
Published: January 2022

Amaç: Bu çalışmada bipolar bozukluk hastalarında çocukluk çağı travması varlığı ve çocukluk çağı travmasının bilişsel duygu düzenleme ve başa çıkma tutumları ile ilişkisinin araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Bu çalışmaya Temmuz 2020 ve Ocak 2021 tarihleri arasında Medipol Üniversitesi Esenler Hastanesine başvuran DSM-5 kriterlerine göre Bipolar bozukluk tanısı konmuş ve halen remisyonda olan 60 hasta dahil edilmiştir. Veriler sosyodemografik veri formu, Çocukluk çağı travma ölçeği (ÇÇTÖ), Bilişsel Duygu Düzenleme Ölçeği ve Başa Çıkma Tutumları Ölçeği (COPE) kullanılarak elde edilmiştir. Veriler Mann Whitney u testi, ki-kare testi ve Spearman korelasyon testi ile değerlendirilmiştir.
Bulgular: Hastaların ortalama yaşları 36,97 ± 10,36 idi. Hastaların çocukluk çağı travma ölçek toplam puanı ortalama 45,82 ± 12,97 idi. Hastaların %76.6 (n=46)’ sında ÇÇTÖ puanı 35 ve üstünde saptandı. Çocukluk çağı travması olan bipolar bozukluk hastalarında, kendini suçlama belirgin olarak yüksek, duygusal odaklı başa çıkma belirgin olarak düşük saptandı. Ayrıca bipolar bozukluk hastalarında çocukluk çağı travması varlığı ile kendini suçlama ve diğerlerini suçlama arasında pozitif yönde anlamlı ilişki, olumlu yeniden değerlendirme ve pozitif yeniden yorumlama ile negatif yönde anlamlı ilişki saptandı.
Sonuç: Bipolar bozukluk hastalarında yüksek oranda çocukluk çağı travması bulunduğu ve çocukluk çağı travmasının bazı bilişsel duygu düzenleme ve başa çıkma tutumlarını etkilediği belirlenmiştir.
Akciğer Kanseri Semptom Taramasının Sigara Bıraktırmadaki Rolü
Authors: YEŞİLOĞLU Reşat , ANNAKKAYA Ali Nihat , KALKANLI Nevin , KARATAŞ Naciye , BALBAY Öner , ARBAK Peri 
Published: January 2022

Amaç: Bu çalışmada Düzce ilinde 30 yaş ve üzeri sigara içenlerde akciğer kanseri semptom taramasının sigara bırakmadaki rolü araştırıldı.
Gereç ve Yöntemler: Randomize 700 hane seçilerek 30 yaş üzeri sigara anamnezi olan 500 olgu çalışmaya alındı. Olguların sigara alışkanlıkları ve akciğer kanseri semptomları bir anket formuyla yüz yüze görüşmeyle sorgulandı. Sigaranın akciğer kanseri için önemli bir risk faktörü olduğu vurgulandı. Halen aktif sigara içen 474 olgunun 353'üne 6 ay sonra telefonla sigara alışkanlıkları yeniden sorgulandı.
Bulgular: Toplam 353 sigara içen olgunun 32’si (%9,1) kadın, 321’i (%90,9) erkekti. Yaş ortalaması 46±9 olan olguların, ortalama 36±24 paket-yıl sigara anamnezi vardı. 130'u (%36,8) sigarayı bırakmayı düşünüyordu ve 65'i (%18,4) sigarayı bırakmayı denemişti. 6 ay sonraki kontrolde 17 olgu (%4,8) sigarayı bırakmış, 59 olgu (%16) sigarayı azaltmış, 2 olgu (%0,6) ise artırmıştı. Sigarayı bırakanların hiçbiri ilk görüşmede bırakmayı düşündüğünü söyleyenler veya daha önce bırakmayı deneyenlerden değildi. Sigarayı bırakanların yaş ortalaması sigara içmeye devam edenlere göre daha yüksekti (p=0,044) ve sigarayı bırakanların daha uzun süredir sigara içme öyküleri vardı (p=0,001). Hemoptizi ve çomak parmak semptomlarının varlığı sigara bırakma oranlarını anlamlı düzeyde artırmaktaydı (sırasıyla p=0,048, p=0,013). Bu çalışmada akciğer kanseri semptom sorgulamasından 6 ay sonraki sigara bırakma oranı (%4,8), kendiliğinden sigarayı bırakma oranından (%1) anlamlı düzeyde yüksekti (p=0,001).
Sonuç: Akciğer kanseri semptom taramasıyla sigara bırakma oranları artırılabilir. Sigara bırakma poliklinikleri yanında bu tip yaklaşımlar sigara mücadelesine katkıda bulunabilir.
Extracorporeal Cardiac Shock Wave-Induced Exosome Derived From Endothelial Colony-Forming Cells Carrying miR-140-3p Alleviate Cardiomyocyte Hypoxia/Reoxygenation Injury via the PTEN/PI3K/AKT Pathway
Authors: Yang Dan , Wang Mingqiang , Hu Zhao , Ma Yiming , Shi Yunke , Cao Xingyu , Guo Tao , Cai Hongbo , Cai Hongyan 
Published: January 2022

Background: Stem cell-derived exosomes have great potential in the treatment of myocardial ischemia–reperfusion injury (IRI). Extracorporeal cardiac shock waves (ECSW) as effective therapy, in part, could activate the function of exosomes. In this study, we explored the effect of ECSW-induced exosome derived from endothelial colony-forming cells on cardiomyocyte hypoxia/reoxygenation (H/R) injury and its underlying mechanisms.Methods: The exosomes were extracted and purified from the supernatant of endothelial colony-forming cells (ECFCs-exo). ECFCs-exo treated with shock wave (SW-exo) or without shock wave (CON-exo) were performed with high-throughput sequencing of the miRNA. H9c2 cells were incubated with SW-exo or CON-exo after H/R injury. The cell viability, cell apoptosis, oxidative stress level, and inflammatory factor were assessed. qRT-PCR was used to detect the expression levels of miRNA and mRNA in cells and exosomes. The PTEN/PI3K/AKT pathway-related proteins were detected by Western blotting, respectively.Results: Exosomes secreted by ECFCs could be taken up by H9c2 cells. Administration of SW-exo to H9c2 cells after H/R injury could significantly improve cell viability, inhibit cell apoptosis, and downregulate oxidative stress level (p &lt; 0.01), with an increase in Bcl-2 protein and a decrease in Bax, cleaved caspase-3, and NF-κB protein (p &lt; 0.05). Notably, miR-140-3p was found to be highly enriched both in ECFCs and ECFCs-exo treated with ECSW (p &lt; 0.05) and served as a critical mediator. SW-exo increased miR-140-3p expression but decreased PTEN expression in H9c2 cells with enhanced phosphorylation of the PI3K/AKT signaling pathway. These cardioprotective effects of SW-exo on H/R injury were blunted by the miR-140-3p inhibitor. Dual-luciferase assay verified that miR-140-3p could directly target the 3′UTR of PTEN mRNA and exert a negative regulatory effect.Conclusion: This study has shown the potential of ECSW as an effective stimulation for the exosomes derived from ECFCs in vitro. SW-exo exerted a stronger therapeutic effect on H/R injury in H9c2 cells possibly via delivering exosomal miR-140-3p, which might be a novel promising strategy for the myocardial IRI.
Prognosis and Risk Factors of Stroke After Thoracic Endovascular Aortic Repair for Stanford Type B Aortic Dissection
Authors: Zha Zhengbiao , Pan Youmin , Zheng Zhi , Wei Xiang 
Published: January 2022

Background: Stroke is a severe complication of patients with type B aortic dissection (TBAD) after thoracic endovascular aortic repair (TEVAR). Our aim is to identify predictors of stroke after TEVAR.Methods: From February 2016 to February 2019, 445 patients with TBAD who underwent TEVAR were retrospectively analyzed. Univariate and multivariate analyses were performed to identify predictors of stroke after TEVAR.Results: The total incidence of stroke was 11.5%, with transient neurological dysfunction (TND) of 10.6% and permanent neurological dysfunction (PND) of 0.9%. The average age of the patients was 53.0 ± 3.2 years, and the male/female ratio was 1.17. Univariate analysis suggested that age, body mass index (BMI), diabetes mellitus, chronic obstructive pulmonary disease (COPD), the urgency of repair, type of anesthesia, and left subclavian artery (LSCA) processing were potential risks factors of stroke after TEVAR. Multiple logistic regression identified that LSCA coverage (OR = 5.920, 95% CI: 2.077–16.878), diabetes mellitus (OR = 3.036, 95% CI: 1.025–8.995), and general anesthesia (OR = 2.498, 95% CI: 1.002–6.229) were independent predictors of stroke after TEVAR.Conclusions: Left subclavian artery (LSCA) coverage, diabetes mellitus, and general anesthesia were independent risk factors of stroke after TEVAR for TBAD.
Titration of Long-Acting Insulin Using Continuous Glucose Monitoring and Smart Insulin Pens in Type 1 Diabetes: A Model-Based Carbohydrate-Free Approach
Authors: El Fathi Anas , Fabris Chiara , Breton Marc D. 
Published: January 2022

ObjectiveMultiple daily injections (MDI) therapy is the most common treatment for type 1 diabetes (T1D), consisting of long-acting insulin to cover fasting conditions and rapid-acting insulin to cover meals. Titration of long-acting insulin is needed to achieve satisfactory glycemia but is challenging due to inter-and intra-individual metabolic variability. In this work, a novel titration algorithm for long-acting insulin leveraging continuous glucose monitoring (CGM) and smart insulin pens (SIP) data is proposed.MethodsThe algorithm is based on a glucoregulatory model that describes insulin and meal effects on blood glucose fluctuations. The model is individualized on patient’s data and used to extract the theoretical glucose curve in fasting conditions; the individualization step does not require any carbohydrate records. A cost function is employed to search for the optimal long-acting insulin dose to achieve the desired glycemic target in the fasting state. The algorithm was tested in two virtual studies performed within a validated T1D simulation platform, deploying different levels of metabolic variability (nominal and variance). The performance of the method was compared to that achieved with two published titration algorithms based on self-measured blood glucose (SMBG) records. The sensitivity of the algorithm to carbohydrate records was also analyzed.ResultsThe proposed method outperformed SMBG-based methods in terms of reduction of exposure to hypoglycemia, especially during the night period (0 am–6 am). In the variance scenario, during the night, an improvement in the time in the target glycemic range (70–180 mg/dL) from 69.0% to 86.4% and a decrease in the time in hypoglycemia (&lt;70 mg/dL) from 10.7% to 2.6% was observed. Robustness analysis showed that the method performance is non-sensitive to carbohydrate records.ConclusionThe use of CGM and SIP in people with T1D using MDI therapy has the potential to inform smart insulin titration algorithms that improve glycemic control. Clinical studies in real-world settings are warranted to further test the proposed titration algorithm.SignificanceThis algorithm is a step towards a decision support system that improves glycemic control and potentially the quality of life, in a population of individuals with T1D who cannot benefit from the artificial pancreas system.
Suppression of the Cycloidal Spin Arrangement in BiFeO3 Caused by the Mechanically Induced Structural Distortion and Its Effect on Magnetism
Authors: Da Silva Klebson Lucenildo , Trautwein Rafael Santiago , Da Silva Rodolfo Bezerra , Fabián Martin , Čižmár Erik , Holub Mariia , Skurikhina Olha , Harničárová Marta , Girman Vladimír , Menzel Dirk , Becker Klaus Dieter , Hahn Horst , Šepelák Vladimír 
Published: January 2022

Bismuth ferrite (BiFeO3) particles are prepared by a combined mechanochemical−thermal processing of a Bi2O3 + α-Fe2O3 mixture. Structural, magnetic, hyperfine, morphological and chemical properties of the as-prepared BiFeO3 are studied using X-ray diffraction (Rietveld refinement), 57Fe Mössbauer spectroscopy, SQUID magnetometry, electron microscopy and energy dispersive X-ray spectroscopy. It is revealed that the structure of the ferrite exhibits the long-range distortion (significantly tilted FeO6 octahedra) and the short-range disorder (deformed FeO6 octahedra). Consequently, these structural features result in the suppression of a space modulated cycloidal spin arrangement in the material. The latter manifests itself by the appearance of only single spectral component in the 57Fe Mössbauer spectrum of BiFeO3. The macroscopic magnetic behavior of the material is interpreted as a superposition of ferromagnetic and antiferromagnetic contributions with a large coercive field and remanent magnetization. Taking into account the average particle size of the as-prepared BiFeO3 particles (∼98 nm), exceeding the typical period length of cycloid (∼62 nm), both the suppression of the spiral spin structure in the material and its partly ferromagnetic behavior are attributed to the crystal lattice distortion caused by mechanical stress during the preparation procedure.
The Optimization of an Anti-VEGF Therapeutic Regimen for Neovascular Glaucoma
Authors: Bai Ling , Wang Yanfen , Liu Xindi , Zheng Yuping , Wang Wenjing , He Na , Tariq Farheen , Wang Feng , Zhang Shu 
Published: January 2022

This study investigates the safety and efficacy of conbercept injection through different routes for neovascular glaucoma (NVG) treatment, in which seventy-four patients (81 eyes) with NVG caused by ischemia retinopathy had participated. Patients were divided into three stages according to the progression of NVG and were randomly assigned to receive intracameral or intravitreal conbercept injection. After conbercept injection, patients experienced improved best-corrected visual acuity (BCVA), good intraocular pressure (IOP) control, and neovascularization of Iris (NVI) regression. In stage III, patients required trabeculectomy with mitomycin C plus pan-retinal photocoagulation (PRP) to achieve complete NVI regression. Compared to the intravitreal group, the intracameral group had significantly lower IOP in 2 days in stage III and 1 day in stages I and II after injection, complete NVI regression before PRP in stages I and II, and better NVI regression in stage III. The rates of hyphema after trabeculectomy and malfunction filtering bleb suffering needle bleb revision were lower in the intracameral group, but only the hyphema rate was significantly different. Injections through different routes are all safe. We recommend intravitreal injections for patients in stages I and II, but for stage III, intracameral injection is better, and trabeculectomy with mitomycin C should be conducted within 2 days after injection to maximally reduce the risk of perioperative hyphema.Trial Registration:ClinicalTrials.gov, identifier NCT03154892.
Optical Coherence Tomographic Features and Prognostic Values of Macular Edema in Vogt-Koyanagi-Harada Disease
Authors: Qin Peng , Ye Zi , Su Guannan , Kijlstra Aize , Yang Peizeng 
Published: January 2022

Purpose: To determine optical coherence tomographic (OCT) features of macular edema (ME) and identify potential prognostic values for ME and visual outcomes in Vogt-Koyanagi-Harada disease (VKH).Methods: In the retrospective case series, a total of 1,377 VKH patients who were seen in a tertiary uveitis center between September 2011 and January 2018 were reviewed on their demographics, visual acuity, ocular and extraocular manifestations, modes of treatment, and OCT examinations. Of these patients, 79 (5.7%) having ME were included for analysis of OCT features. Four patients were missed without ME resolution, and the remaining 75 patients who either had ME resolved or were followed up for 2 years were included for analysis of disease outcomes.Results: Of the 115 affected eyes in these 79 patients, 100 (87.0%) had cystoid ME (CME), accounting for the most common OCT feature of VKH-related ME. Disruption of the inner-segment/outer-segment junction (IS/OS) band seen in 33 (28.7%) affected eyes of 24 (30.4%) patients was found as a risk factor for the development of persistent ME [10 of 62 (16.1%) vs. 13 of 13 (100%); P &lt; 0.001] and a poor visual outcome (1.16 ± 0.42 vs. 1.17 ± 0.46 in logMAR unit; P = 0.89). CME patients with a concurrent choroidal neovascular membrane often had a disrupted IS/OS band, thus becoming refractory cases. A 6-month well-controlled intraocular inflammation following standard treatment regimens was found to associate with complete resolution of the refractory edema [4 of 5 (80%) vs. 2 of 13 (15%); P = 0.02].Conclusions: Intraretinal cystoid changes are most commonly seen in the edematous macula of VKH patients. Disruption of the IS/OS band is a useful risk sign for poor ME and visual outcomes in VKH-related ME, and a long-term well-controlled intraocular inflammation may be critical for the resolution of refractory cases.
Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis
Authors: Jin Junyan , Sun Runsong , Mu Tingting , Jiang Taiyi , Dai Lili , Lu Hongyan , Ren Xianlong , Chen Jing , Ye Jingrong , Sun Lijun , Wu Hao , Zhang Tong , Zou Huachun , Su Bin 
Published: January 2022

Background: The use of post-exposure prophylaxis (PEP) is effective in reducing HIV risk, but it is underused by men who have sex with men (MSM) due to certain psychological and sociostructural factors. This article assessed the awareness and use of PEP among MSM in an effort to increase the visibility and uptake of PEP among at-risk populations.Methods: We conducted a systematic literature search of the PubMed, Web of Science, PsycINFO, and Google Scholar electronic databases. Studies were screened for inclusion, and relevant data were abstracted, assessed for bias, and synthesized. Pooled effect estimates were calculated using random effects meta-analysis, meta-regression and subgroup analysis, and a qualitative review and risk of bias assessment were performed (PROSPERO, CRD42019123815).Results: Twenty eligible studies involving 12,579 MSM were included in the meta-analysis. The pooled estimate of the proportions of MSM who were aware of PEP was modest at 59.9% (95% CI: 50.5~68.7) and that of MSM who previously used PEP was very low at 4.9% (95% CI: 2.4~9.8). PEP awareness showed no clear change over time, while PEP use significantly changed over time. Multiple factors affected awareness, including educational attainment, race/ethnicity, levels of HIV stigma, access to condoms, and so on. Many factors could potentially impede or facilitate the use of PEP, such as income, lack of PEP information, and partnership.Conclusion: We observed that PEP is an underused HIV prevention strategy among MSM and that once MSM become aware of PEP, the majority are willing to use it if they are supported appropriately in terms of a range of individual, social, and structural barriers.Systematic Review Registration: http://www.cdr.york.ac.uk/prospero, PROSPERO [CRD42019123815].