bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer’s Disease Model
Authors: Sanjay  , Shin Jae-Ho , Park Miey , Lee Hae-Jeung 
Published: June 2022

Abstract Microglial polarization plays an essential role in the progression and regression of neurodegenerative disorders. Cyanidin-3-O-glucoside (C3G), a dietary anthocyanin found in many fruits and vegetables, has been reported as an antioxidant, anti-inflammatory, and antitumor agent. However, there have been no reports on whether C3G can regulate the M1/M2 shift in an Alzheimer’s disease model. We attempted to investigate the effects of C3G on M1/M2 polarization and the mechanism to regulate anti-inflammation and phagocytosis, both in vitro and in vivo. HMC3 cells were treated with β-amyloid (Aβ42) in the presence or absence of 50 μM C3G for different time intervals, and APPswe/PS1ΔE9 mice were orally administered 30 mg/kg/day of C3G for 38 weeks. The in vitro data revealed that C3G could shift the M1 phenotype of microglia to M2 by reducing the expression of M1-specific markers (CD86 and CD80), inflammatory cytokines (IL-Iβ, IL-6, TNF-α), reactive oxygen species, and enhancing the expression of M2-specific markers (CD206 and CD163). The APPswe/PS1ΔE9 mice results were consistent with the in vitro data, indicating a significant reduction in inflammatory cytokines and higher expression of M2-specific markers such as CD206 and Arg1 in C3G-treated Alzheimer’s disease model mice. Additionally, C3G was found to upregulate PPARγ expression levels both in vitro and in vivo, whereas a PPARγ antagonist (GW9662) was found to block C3G-mediated effects in vitro. In this study, we confirmed that C3G could regulate microglial polarization by activating PPARγ and eliminating accumulated β-amyloid by enhancing Aβ42 phagocytosis through the upregulation of TREM2.
Satellite maneuver detection and estimation with optical survey observations
Authors: Pastor Alejandro , Escribano Guillermo , Sanjurjo-Rivo Manuel , Escobar Diego 
Published: June 2022

AbstractManeuver detection and estimation is deemed crucial for maintaining catalogs of Resident Space Objects (RSOs) as it helps to avoid sets of duplicated objects and track correlation issues. In fact, maneuvers, along with launches and break-up events, are the main source of potential new object detections during RSOs cataloging activities. For the continuous and reliable provision of Space Situational Awareness (SSA) and Space Traffic Management (STM) services, a challenging trade-off between detection time and characterization accuracy of maneuvers needs to be performed. In this paper, two novel and operationally feasible methodologies are proposed for maneuver detection and estimation. The first, a track-to-orbit methodology, uses a pre-maneuver orbit to linearize the dynamics and estimate the single burn that minimizes the residuals of the post-maneuver tracks. The second, an orbit-to-orbit methodology, estimates the double burn that solves a minimization problem between the pre-maneuver and post-maneuver orbits. Both methods, based on an optimal control approach, are not only proposed to tackle the maneuver estimation problem but also to be integrated on operational and robust association frameworks. Results are presented for optical scenarios with both simulated and real data, providing insightful conclusions on the capabilities, performance and limitations of the proposed methods. Particular emphasis is given to the importance of the track association, since a single track is usually not enough to perform a reliable estimation of the maneuver. Besides, the capability of the methods to provide a solution to the association problem, even when not perfectly characterizing the true maneuver, is discussed.
VAT chargeability of football intermediaries’ commissions in EU Law, in the light of the EU–UK Trade and Cooperation Agreement
Authors: Onesti Niccolò Emanuele 
Published: June 2022

AbstractThis article discusses the Value-Added Tax (VAT) discipline relating to the representation services offered by football intermediaries in the contractual negotiation of the employment contract between the player and the club(s). The analysis is carried out taking into consideration the relevant legislative provisions of European Union (EU) law as well as the case law of the European Court of Justice (ECJ) and the findings of the EU VAT Committee. The VAT discipline of representation services provided by football intermediaries is first analyzed in light of the EU legislative acts regulating the different legal figures of intermediation contracts and the effects on the EU internal market. Then, the legal nature of the “intermediation commission”—as the VAT chargeable event—and the “place of supply of the intermediation service”—as the place of taxation—as qualified by EU tax law, are studied. Finally, the EU–UK Trade and Cooperation Agreement (TCA) provisions regarding VAT chargeability of intermediation services are analyzed. The article concludes arguing that, at the moment, it does not seem that the TCA has specifically reformed the regulation of the VAT chargeability of the intermediation commission received by football agents for their representation services in negotiating an employment contract between the player and the club(s).
Effect of Ti Addition and Heat Treatment on Electrochemical Properties of Cast Fe35Mn31Ni18Al13Tix HEAs
Authors: Ibrahim Mohamed , El-Hadad Shimaa , Khalifa Waleed , Shoeib Madiha 
Published: June 2022

AbstractHigh Entropy Alloys (HEAs) are one of the new families of alloys that gained the attention of researchers as a new approach to materials design. The special compositional design of these alloys results in unique microstructures and hence distinguished properties. Corrosion resistance is one of the most important properties of any material used for structural components. Therefore, it is of interest to investigate the electrochemical properties of such recent groups of HEAs alloys to understand their corrosion behavior. In the current study, the electrochemical properties of cast Fe35Mn31Ni18Al13Tix HEAs prepared by induction melting were investigated in 3.5% NaCl and 5% H2SO4 solutions. It was observed that both Ti addition (0.0–3 wt%) and heat treatment (900 °C at 10 and 20 h) altered the alloys microstructure and, hence, affected their corrosion behavior. The base alloy without Ti showed higher resistance to corrosion in both NaCl and H2SO4 solutions compared to Ti-containing alloys. Heat treatment for 10 h increased significantly the corrosion resistance of the as-cast alloys regardless of the Ti content. On the other hand, heat treatment for 20 h affected negatively the corrosion resistance of the alloy without Ti. Therefore, the electrochemical properties of HEAs can be well controlled through alloying additives and heat treatment.
4D printing of soft orthoses for tremor suppression
Authors: Mohammadi Moslem , Zolfagharian Ali , Bodaghi Mahdi , Xiang Yong , Kouzani Abbas Z. 
Published: June 2022

AbstractTremor is an involuntary and oscillatory movement disorder that makes daily activities difficult for affected patients. Hand tremor-suppression orthoses are noninvasive, wearable devices designed to mitigate tremors. Various studies have shown that these devices are effective, economical, and safe; however, they have drawbacks such as large weight, awkward shape, and rigid parts. This study investigates different types of tremor-suppression orthoses and discusses their efficiency, mechanism, benefits, and disadvantages. First, various orthoses (with passive, semi-active, and active mechanisms) are described in detail. Next, we look at how additive manufacturing (AM) has progressed recently in making sensors and actuators for application in tremor orthoses. Then, the materials used in AM are further analyzed. It is found that traditional manufacturing problems can be solved with the help of AM techniques, like making orthoses that are affordable, lighter, and more customizable. Another concept being discussed is using smart materials and AM methods, such as four-dimensional (4D) printing, to make orthoses that are more comfortable and efficient.Graphic abstract
Autophagy is required for spermatogonial differentiation in the Drosophila testis
Authors: Varga Virginia B. , Schuller Dóra , Szikszai Fanni , Szinyákovics Janka , Puska Gina , Vellai Tibor , Kovács Tibor 
Published: June 2022

AbstractAutophagy is a conserved, lysosome-dependent catabolic process of eukaryotic cells which is involved in cellular differentiation. Here, we studied its specific role in the differentiation of spermatogonial cells in the Drosophila testis. In the apical part of the Drosophila testis, there is a niche of germline stem cells (GSCs), which are connected to hub cells. Hub cells emit a ligand for bone morhphogenetic protein (BMP)-mediated signalling that represses Bam (bag of marbles) expression in GSCs to maintain them in an undifferentiated state. GSCs divide asymmetrically, and one of the daughter cells differentiates into a gonialblast, which eventually generates a cluster of spermatogonia (SG) by mitoses. Bam is active in SG, and defects in Bam function arrest these cells at mitosis. We show that BMP signalling represses autophagy in GSCs, but upregulates the process in SG. Inhibiting autophagy in SG results in an overproliferating phenotype similar to that caused by bam mutations. Furthermore, Bam deficiency leads to a failure in downstream mechanisms of the autophagic breakdown. These results suggest that the BMP-Bam signalling axis regulates developmental autophagy in the Drosophila testis, and that acidic breakdown of cellular materials is required for spermatogonial differentiation.
An Optimized Neural Network Prediction Model for Reservoir Porosity Based on Improved Shuffled Frog Leaping Algorithm
Authors: Liu Miaomiao , Yao Dan , Guo Jingfeng , Chen Jing 
Published: June 2022

AbstractEfficient and accurate porosity prediction is essential for the fine description of reservoirs, for which an optimized BP neural network (BPNN) prediction model is proposed. Aiming at the problem that the BPNN is sensitive to initialization and converges to local optimum easily, an improved shuffled frog leaping algorithm (ISFLA) is proposed based on roulette and genetic coding. Firstly, a roulette mechanism is introduced to improve the selection probability of elite individuals, thus enhancing the global optimization ability. Secondly, a genetic coding method is carried out by making full use of effective information such as the global and local optimal solutions and the boundary values of subgroups. Subsequently, the ISFLA algorithm is verified on 12 benchmark functions and compared with four intelligent optimization algorithms, and experimental results show its good optimization performance. Finally, the ISFLA algorithm is applied to the optimization of initial weights and thresholds of the BPNN, and a new model named ISFLA_BP is proposed to study the porosity prediction problem. The logging data is preprocessed by grey correlation analysis and deviation normalization, and then the effective prediction of porosity is achieved by natural gamma, density and other relevant parameters. The performance of ISFLA_BP model is compared with the standard three-layer BPNN and four BPNN parameter optimization methods based on swarm intelligence algorithms. Experimental results show that the proposed model has higher training accuracy, stability and faster convergence speed, with a mean square error of 0.02, and its prediction accuracy for porosity is higher than that of the other five methods.
SARS-CoV-2 and RT-PCR Testing in Travelers: Results of a Cross-sectional Study of Travelers at Iraq’s International Borders
Authors: Salih Doaa Abdulkhaleq , Ahmed Jivan Qasim , Qader Marwan Khalil , Shukur Mohammed S. , Zeebaree Bayar K. A. , Sadeq Mateen Bahjat , Mohammed Sirwan Najeeb , Masiha Hushank Nadhmi , Abdullah Ibrahim Mohammed , Mohammed Omar , Taha Luqman Saleh , Al-Qadi Rawand 
Published: June 2022

AbstractBackground:In late 2019, a novel coronavirus was detected in Wuhan, China, that caused a pandemic by September 2021, resulting in 224,180,411 cases and more than 4,600,000 deaths worldwide. In response to the pandemic, the Autonomous Kurdistan Regional Government of Iraq (KRG) imposed strict infection control measures at its borders for all travelers from neighboring countries, wherein each traveler was subjected to a mandatory reverse transcription polymerase chain reaction (RT-PCR) test on arrival to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected travelers. The aim of this study is to determine the rate of infection with SARS-CoV-2 among the travelers entering Kurdistan region through Ibrahim Al-Khalil crossing point with Turkey as a predictor for the upcoming infection waves.Methods:The data of RT-PCR tests to detect SARS-CoV-2 in all travelers arriving at the Ibrahim Al-Khalil Border Crossing between Iraq and the Republic of Turkey were reviewed from August 21, 2020 to August 21, 2021.Results:It was found that there were 9873 cases of SARS-CoV-2 infections among 1,082,074 travelers during the study period.Conclusions:This study shows the importance of mass testing of travelers at border crossings to control the spread of SARS-CoV-2 infection.
Supporters of India's BJP: Distinctly Populist and Nativist
Authors: Ammassari Sofia , Fossati Diego , McDonnell Duncan 
Published: June 2022

AbstractWhile India's Bharatiya Janata Party (BJP) has become recognized as a populist radical right (PRR) party under the leadership of Narendra Modi, we do not know whether this PRR supply is matched yet by PRR attitudes among its supporters. Using an original survey, we therefore investigate: Do BJP supporters display PRR attitudes? We find that those who feel close to the BJP have stronger populist and nativist attitudes than other Indian citizens. However, authoritarianism is not a distinguishing feature of BJP supporters. We argue that the similarities between the drivers of support for European PRR parties and for the BJP reinforce the idea that radical right populism is a coherent global phenomenon both in terms of supply and demand. Finally, we discuss how our study shows that party support in India is more ideologically rooted than has previously been thought.
Ireland, the Basques and the Spanish Civil War
Authors: McCreanor Kyle 
Published: June 2022

AbstractIn late 1936, two Irishmen arrived in the Spanish Basque Country. One was General Eoin O'Duffy, signing the terms of agreement for an Irish Brigade to support the military uprising against the Second Spanish Republic. Meanwhile, socialist republican George Gilmore journeyed across the Pyrenees in search of a Basque nationalist priest he had met four years earlier. While O'Duffy was drawn into the conflict by traditionalist monarchists from Navarre, his leftist opponents in Ireland mounted a pro-republic propaganda campaign focused on the war effort of the rival Basque nationalists. In effect, a civil war between Basques became entangled with the legacy of the Irish Civil War, as old rivals such as O'Duffy and Gilmore constructed alliances on opposite sides of the conflict as it played out in this small corner of Spain. This article places a new emphasis on the Basque dimension of Ireland's engagement with the Spanish Civil War and illustrates how it was shaped by earlier Basque-Irish relations.
Ageing impairs protective immunity and promotes susceptibility to murine visceral leishmaniasis
Authors: Loureiro Salgado Caio , Mendéz Corea Andrés Felipe , Covre Luciana Polaco , De Matos Guedes Herbet Leonel , Falqueto Aloisio , Gomes Daniel Cláudio Oliviera 
Published: June 2022

AbstractIt is well accepted that the impact of diseases is generally more detrimental in elderly individuals than in younger ones. Changes in the immune system due to ageing can directly affect the ability to respond effectively to infections and may contribute to the higher morbidities and mortalities in the elderly population. Leishmaniasis is a complex of clinically unique diseases caused by obligate intracellular protozoa belonging to genusLeishmania, wherein visceral leishmaniasis (VL) is the most severe form and is fatal if left untreated. In this study, aged mice (72 weeks old) presented increased susceptibility toL. infantuminfection compared to younger mice (4–6-week-old), with notable parasitism in both the spleen and liver, as well as exhibiting hepatosplenomegaly. A pronounced inflammatory profile was observed in the aged-infected mice, with excessive production of TNF-αand nitrite, along with diminished IFN-γproduction and reduced proliferative capacity of T cells (assessed by expression of the Ki67 marker). Additionally, both CD4+and CD8+T cells from the aged-infected mice presented increased expression of the inhibitory receptors PD-1 and KLRG1 that strongly correlated with the parasitism found in the liver and spleen of this group. Overall, the data reported in this study suggests for the first time that ageing may negatively impact the VL outcome and provides a perspective for new therapeutic strategies involving manipulation of immunosenescence features againstLeishmaniainfection.
Judicial Power and the Shifting Purpose of Article V
Authors: Stohler Stephan , Bateman David , Woodward-Burns Robinson 
Published: June 2022

AbstractArticle V of the U.S. Constitution, which establishes the formal amendment procedure, sets perhaps the highest bar to reform of any national constitution, discouraging amendment. But despite these challenges, members of Congress have proposed nearly twelve thousand constitutional amendments, with most introduced after the New Deal, raising questions about why members engage in such seemingly futile efforts. We argue that the rise of judicial power following the New Deal substantially decreased the importance of Article V as a tool for constitutional reform. But, by largely abandoning this purpose, members of Congress have repurposed Article V as a mechanism for constitutional position-taking, even though—indeed, perhaps precisely because—their efforts at formal constitutional revision have little chance for success. Through a mixed-methods approach, we first document the shifting purpose of Article V at an aggregate level by coding all 11,969 proposed constitutional amendments throughout American history. We then substantiate the shifting purpose of Article V through a series of in-depth case studies focused on polygamy, women's suffrage, Equal Rights Amendments, and Federal Marriage Amendments. Taken together, this evidence helps us understand Article V as a repurposed institution and suggests that textually static constitutional provisions nonetheless may be open to reinvention at the behavioral level in subtle but important ways.
Hurricane Ida Emergency Medicine Resident Disaster Response
Authors: Fenton Ronald , Flitter Ben , Kessler Raymond , Herbert Kyle , Maslanka Meghan 
Published: June 2022

AbstractThis report describes the medical response, action plan, and after-action summary adopted by the Louisiana State University (LSU) New Orleans - Emergency Medicine (EM) Residency Program in response to Hurricane Ida which occurred in New Orleans, Louisiana (USA) late August through early September 2021. New Orleans has an estimated 385,000 people within the 350 square miles surrounding the metropolitan area, with greater than one million residents in all of Louisiana. In the two-week time span during and following the event, residents, nurses, attendings, ancillary staff, and Emergency Medical Services (EMS) managed a substantial intensification in daily EM activities due to a substantial lack of resources (ie, food, electricity, water, housing, medications, oxygen, and primary care). This report outlines the redistribution of emergency department (ED) residents within the primary clinical site, University Medical Center New Orleans (UMCNO); describes the daily communication flow from the chief residents and program director; describes the daily EM response; describes the pre- and post-action plans based on those efforts during hurricane operations; and summarizes the obtained information.
Hydrologic Export of Soil Organic Carbon: Continental Variation and Implications
Authors: Hararuk O. , Jones S. E. , Solomon C. T. 
Published: June 2022

AbstractSoil is the largest terrestrial carbon (C) reservoir and a large potential source or sink of atmospheric CO₂. Soil C models have usually focused on refining representations of microbe‐mediated C turnover, whereas lateral hydrologic C fluxes have largely been ignored at regional and global scales. Here, we provide large‐scale estimates of hydrologic export of soil organic carbon (SOC) and its effects on bulk soil C turnover rates. Hydrologic export of SOC ranged from nearly 0 to 12 g C m−2yr−1 amongst catchments across the conterminous United States, and total export across this region was 14 (95% CI 4‐41) Tg C/yr. The proportion of soil C turnover attributed to hydrologic export ranged from <1% to 20%, and averaged 0.97% (weighted by catchment area; 95% CI 0.3%–2.6%), with the lowest values in arid catchments. Ignoring hydrologic export in C cycle models might lead to overestimation of SOC stocks by 0.3–2.6 Pg C for the conterminous United States. High uncertainty in hydrologic C export fluxes and potentially substantial effects on soil C turnover illustrate the need for research aimed at improving our mechanistic understanding of the processes regulating hydrologic C export.
Models of Injection‐Induced Aseismic Slip on Height‐Bounded Faults in the Delaware Basin Constrain Fault‐Zone Pore Pressure Changes and Permeability
Authors: Dvory Noam Z. , Yang Yuyun , Dunham Eric M. 
Published: June 2022

AbstractInversions of InSAR ground deformation in the Delaware Basin have revealed an aseismic slip on semi‐optimally oriented normal faults located close to disposal wells. The slip, occurring over 3–5 years, extends approximately 1 km down‐dip, over 10 km along strike, and reaches 25 cm. We develop and calibrate 2D and pseudo‐3D coupled pore pressure diffusion and rate‐state models with velocity‐strengthening friction tailored to this unique height‐bounded fault geometry. Pressure diffusion is limited to a high‐permeability fault damage zone, and the net influx of fluid is adjusted to match the observed slip. A 1–2 MPa pressure increase initiates slip, with ∼5 MPa additional pressure increase required to produce ∼20 cm slip. Most slip occurs at approximately constant friction. Fault zone permeability must exceed ∼10−13 m2 to match the along‐strike extent of slip. Models of the type developed here can be used to operationally manage injection‐induced aseismic slip.