Adrenaline autoinjector is under-prescribed in typical cold urticaria patients living in tropical climate countries
Authors: Bizjak Mojca , Košnik Mitja , Dinevski Dejan , Francis Thomsen Simon , Fomina Daria , Borzova Elena , Kulthanan Kanokvalai , Meshkova Raisa , Aarestrup FernandoM , Melina Ahsan Dalia , Al-Ahmad Mona , Altrichter Sabine , Bauer Andrea , Brockstädt Maxi , Costa Célia , Demir Semra , Fachini Criado Roberta , Felipe Ensina Luis , Gelincik Asli , Giménez-Arnau Ana Maria , Gonçalo Margarida , Gotua Maia , Grønlund Holm Jesper , Inomata Naoko , Kasperska-Zajac Alicja , Khoshkhui Maryam , Klyucharova Aliya , Kocatürk Emek , Lu Rongbiao , Makris Michael , Maltseva Natalya , Pasali Maria , Paulino Marisa , Pesqué David , Peter Jonny , Dario Ramón German , Ritchie Carla , Oliveira Rodrigues Valle Solange , Rudenko Michael , Sikora Agnieszka , Wagner Nicola , Xepapadaki Paraskevi , Xue Xiaoyang , Zhao Zuotao , Terhorst-Molawi Dorothea , Maurer Marcus 
Published: April 2022

Background: The diagnosis of typical cold urticaria (ColdU) relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). Till date, it is largely unclear how often patients with ColdU receive adrenaline treatment and are provided with an adrenaline autoinjector (AAI). Methods: An international, cross-sectional study, COLD-CE (i.e., comprehensive evaluation of ColdU and other cold-induced reactions), was carried out at 32 UCAREs. Detailed histories were taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced (i.e., by cold water, air, or surfaces) involvement of the skin and/or visible mucosal tissue and at least one of the symptoms (cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms). Results: Of the 551 ColdU patients, 75% (n = 412) had a positive CST. Of them, concomitant chronic spontaneous urticaria was diagnosed in 10%. Of 372 patients with stand-alone ColdU, 69% were women and 91% adults. Their median age was 36 (IQR 26 − 48) years. Patients were also categorized into residents of countries with a tropical (n = 33), temperate (n = 264), or cold (n = 75) climate (Table 1: R13C1, R17C1, R21C1). AAI was more often prescribed to residents of temperate than tropical countries (30% vs. 12%, p = .038; Table 1: R31C1), although the frequency of ColdA did not significantly differ between these countries (44% vs. 42%, p = 1.000; R29C2). Residents of tropical countries had a higher frequency of ColdA induced by cold air than residents of temperate (36% vs. 12%, p = .001; R29C4) or cold (36% vs. 12%, p = .007; R25C4) countries. Cardiovascular manifestations induced by cold air were diagnosed in 33% (n = 11) of residents of tropical countries, but only 18% (n = 2) and 36% (n = 4) of them had received adrenaline and AAI, respectively (R13 − 15C7). Furthermore, hypotension and/or loss of consciousness induced by cold air occurred in 18% (n = 6) of patients, but only 17% (n = 1) received adrenaline (R13 − 14C10). ColdA was induced by complete cold water immersion in 9% (n = 3) of patients, and none of them received adrenaline treatment nor AAI (R13 − 15C3). Conclusion: Our findings suggest that ColdA is undertreated and call for changes in ColdU management. Acknowledgement: This work benefited from the support of the GA2LEN UCARE network (www.ga2len-ucare.com), and the results reported here were presented at the First Qatar Allergy Conference and published in Allergy, the European Journal of Allergy and Clinical Immunology.