bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibular Free Flap and Iliac Crest Free Flap Mandibular Reconstruction In Patients With Mandibular Ameloblastomas
Authors: Piotrowska-Seweryn Agnieszka , Szymczyk Cezary , Walczak Dominik A. , Krakowczyk Łukasz , Maciejewski Adam , Hadasik Grzegorz , Wierzgoń Janusz , Szumniak Ryszard , Drozdowski Piotr , Paul Piotr , Grajek Maciej 
Published: February 2022

Abstract:
Ameloblastoma (AM) is the most common, locally aggressive odontogenic tumor. It comprises about 1% of all head and neck neoplasms. It occurs mainly in young adults in their 3rd and 4th decade of life. It localizes in the mandible in about 80% of the cases. According to the 2017 WHO classification, 4 types of ameloblastoma can be distinguished: ameloblastoma (previously referred to as solid/multicystic-SMA; the “conventional type” AM), unicystic (AM-UA), extraosseous/peripheral (AM-PA), and malignant/metastatic (AM-MA). Solid, multicystic is the most common type. It is characteristic for its aggressiveness and high risk of recurrence. Radical resection with consecutive reconstruction is the treatment of choice of mandibular ameloblastomas.
In this study, the authors present their experience in the surgical treatment of mandibular ameloblastomas with vascularized free flap reconstructions. They discuss new technological possibilities that could improve the precision of the reconstructive procedure and therefore result in the better aesthetic outcome.
The retrospective study of a group of 21 patients suffering from mandibular ameloblastoma who underwent segmental man-dibulectomy with simultaneous microvascular free flap reconstruction was conducted. A thorough clinical analysis with various aspects was performed. Tumors resected before 2017 were double checked patomorphologically and assigned to the corrected subtype group.
Seven patients were admitted to the department due to recurrent ameloblastoma. The most common localization of the tumor was the mandibular body (n = 6) andbodywith ramus of the mandible (n = 6). A total amount of 10 iliac crest free flaps and 12 fibular free flaps were performed. Complications were reported in 4 patients. A purulent oro-cutaneus fistula occurred in 3 patients. There was a flap failure in each reconstructive group. The virtual surgical planning with intraoperative cone-beam computed tomography was used in 3 patients. Dentition implantation was conducted in 4 patients (3 simultaneously, 1 postponed). The mean follow-up was 5 years and 8 months.
Radical resection that covers radical segmental mandibulect-omy with immediate microvascular free flap reconstruction is a first-line and only effective treatment of mandibular ameloblas-tomas, that eliminates the risk of recurrence. The extent of surgical margins seems not to influence the recurrence rate, yet further investigation with statistical analysis should be performed. The choice of the adequate free flap must be adapted to dimensions and localization of the tumor and to each patient individually.
New technologies such as virtual surgical planning with 3D models and intraoperative cone-beam computed tomography can make the reconstruction more accurate, improving patient's quality of life.
Novel approaches to measuring neurocognitive functions in Alzheimer's disease clinical trials
Authors: Carlson Scott , Kim Hyun , Devanand Davangere P. , Goldberg Terry E. 
Published: February 2022

Purpose of review
We comprehensively examined recent advancements in developing novel cognitive measures that could significantly enhance detection of outcome changes in Alzheimer's disease clinical trials. Previously established measures were largely limited in their ability to detect subtle cognitive declines in preclinical stages of Alzheimer's disease, particularly due to weak psychometric properties (including practice effects and ceiling effects) and requirement of in-person visits that impacted ascertainment.

Recent findings
We present novel cognitive measures that were designed to exhibit reduced practice effects and stronger correlations with Alzheimer's disease biomarkers. In addition, we summarized some recent efforts in developing remote testing measures protocols that are aimed to overcome the limitations and inconvenience of in-person testing, and digital phenotyping, which analyses subtle forms of digital behaviour indicative of cognitive phenotypes. We discuss each measure's prognostic accuracy and potential utility in Alzheimer's disease research while also commenting on their limitations. We also describe our study, the Development of Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD), that employed a parallel group design in which novel measures and established measures are compared in a clinical trials armature.

Summary
Overall, we believe that these recent developments offer promising improvements in accurately detecting clinical and preclinical cognitive changes in the Alzheimer's disease spectrum; however, further validation of their psychometric properties and diagnostic accuracies is warranted before reliably implementing these novel measures in Alzheimer's disease clinical trials.
The role of the locus coeruleus/norepinephrine system in the pathogenesis of neurodegenerative disorders: An update
Authors: Malatt Camille , Tagliati Michele 
Published: February 2022

Purpose of review
The aim of this review was to provide an update on current and emerging knowledge of the neuropathological processes affecting the locus coeruleus/norepinephrine (LC/NE) system, their effect on Alzheimer's disease and Parkinson's disease symptomatology, including efforts to translate these notions into therapeutic actions targeting the noradrenergic system.

Recent findings
Over the past 2 years, work from multiple groups has contributed to support an early role of locus coeruleus degeneration and/or hyperactivation in the neurodegenerative process, including a trigger of neuroinflammation. Imaging advances are allowing the quantification of locus coeruleus structural features in vivo, which is critical in the early stages of disease. Nonmotor and noncognitive symptoms, often secondary to the involvement of the LC/NE system, are becoming more important in the definition of these diseases and their treatment.

Summary
The diverse symptomatology of Parkinson's disease and Alzheimer's disease, which is not limited to cardinal motor and cognitive abnormalities, strongly suggests a multisystem neurodegenerative process. In this context, it is increasingly clear how the LC/NE system plays a key role in the initiation and maintenance of the neurodegenerative process.
Chemophototherapy Overcomes Doxorubicin Resistance in Human Ovarian Cancer Cells
Authors: Ghosh Sanjana , Chitgupi Upendra , Sunar Ulas , Lovell Jonathan F. 
Published: February 2022

AbstractPorphyrin-phospholipid (PoP) liposomes loaded with Doxorubicin have been demonstrated to be an efficient vehicle for chemophototherapy (CPT). Multi-drug resistance (MDR) of cancer cells is a known resistance mechanism for cancer chemotherapies. We report a phototherapeutic measure to overcome Dox-resistance using Doxorubicin (Dox)-loaded PoP liposomes. In vitro studies using free Dox or Dox loaded into liposomes with 2 mol.% showed human ovarian carcinoma A2780 cells were more susceptible to these drugs compared to the corresponding Dox-resistant A2780-R cells. In contrast, when CPT was applied with LC-Dox-PoP liposomes, effective killing of both non-resistant and resistant A2780 cell lines was observed. An in vivo study to assess the efficiency of LC-Dox-PoP liposomes with phototreatment showed effective tumor shrinkage and prolonged survival of athymic nude mice bearing A2780-R tumor xenografts. Biodistribution analysis demonstrated enhanced tumoral drug uptake in Dox-resistant tumors with CPT, pointing to the likelihood that increased drug delivery overcame resistance mechanisms to provide for improved anti-cancer therapy.
Reliability of citations of medRxiv preprints in articles published on COVID-19 in the world leading medical journals
Authors: Gehanno Jean-Francois , Grosjean Julien , Darmoni Stefan J. , Rollin Laetitia 
Published: February 2022

AbstractBackgroundPreprints have been widely cited during the COVID-19 pandemics, even in the major medical journals. However, since subsequent publication of preprint is not always mentioned in preprint repositories, some may be inappropriately cited or quoted. Our objectives were to assess the reliability of preprint citations in articles on COVID-19, to the rate of publication of preprints cited in these articles and to compare, if relevant, the content of the preprints to their published version.MethodsArticles published on COVID in 2020 in the BMJ, The Lancet, the JAMA and the NEJM were manually screened to identify all articles citing at least one preprint from medRxiv. We searched PubMed, Google and Google Scholar to assess if the preprint had been published in a peer-reviewed journal, and when. Published articles were screened to assess if the title, data or conclusions were identical to the preprint version.ResultsAmong the 205 research articles on COVID published by the four major medical journals in 2020, 60 (29.3%) cited at least one medRxiv preprint. Among the 182 preprints cited, 124 were published in a peer-reviewed journal, with 51 (41.1%) before the citing article was published online and 73 (58.9%) later. There were differences in the title, the data or the conclusion between the preprint cited and the published version for nearly half of them. MedRxiv did not mentioned the publication for 53 (42.7%) of preprints.ConclusionsMore than a quarter of preprints citations were inappropriate since preprints were in fact already published at the time of publication of the citing article, often with a different content. Authors and editors should check the accuracy of the citations and of the quotations of preprints before publishing manuscripts that cite them.Key pointsMajor medical journals cite preprints in their articles on COVID41% of the preprint cited were in fact already published when the citing article was published online and the published version should have been cited instead40% of them displayed difference in the data when comparing to the published version and 10% in the conclusionsDifferences in content between the preprint and the published version are also common for preprints published after the publication of the citing article
Normalization of aperiodic ECoG components indicates fine motor recovery after sensory cortical stroke in mice
Authors: Biskamp Jonatan , Cainzos Sara Isla , Higgen Focko L. , Gerloff Christian , Magnus Tim 
Published: February 2022

AbstractElectrophysiological signatures of ischemic stroke might help to develop a deeper understanding of the mechanisms of recovery. Here, analyses of multichannel electrocorticography (ECoG) in awake mice demonstrated that the shape of power spectral density (PSD) is modulated in the vicinity of sensory cortical stroke. PSD consists of both rhythmic oscillatory and non-rhythmic, aperiodic components. The alteration of spectrum shape was reflected in a transient increase of aperiodic exponents, while the relative power and frequency of slow oscillations remained unchanged in the peri-infarct cortex. Exponents derived from motor areas significantly correlated with recovery of fine motor deficits of the contralateral forepaw thus indicating functional modifications of neuronal activity. In conclusion, aperiodic spectral exponents exhibited a unique spatiotemporal profile in the mouse cortex after stroke and might complement future studies providing a dynamic link from pathophysiology to behavior.
Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission
Authors: Virtanen Jenni , Aaltonen Kirsi , Kegler Kristel , Venkat Vinaya , Niamsap Thanakorn , Kareinen Lauri , Malmgren Rasmus , Kivelä Olga , Atanasova Nina , Österlund Pamela , Smura Teemu , Sukura Antti , Strandin Tomas , Dutra Lara , Vapalahti Olli , Nordgren Heli , Kant Ravi , Sironen Tarja 
Published: February 2022

AbstractWe report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that minks remain virus RNA positive for days, develop clinical signs and histopathological changes, and transmit the virus to uninfected recipients warranting further studies and preparedness.
Inducing a mental context for associative memory formation with real-time fMRI neurofeedback
Authors: Collin Silvy H.P. , van den Broek Philip , van Mourik Tim , Desain Peter , Doeller Christian F. 
Published: February 2022

AbstractMemory, one of the hallmarks of human cognition, can be modified when humans voluntarily modulate single neuron or neural population activity using neurofeedback. However, it is currently unknown whether memory is facilitated or impaired after such neural perturbation. In this study, participants memorized objects while we trained them with abstract neurofeedback to modulate their brain activity patterns in the ventral visual stream to represent either faces or houses. The neurofeedback created an implicit face or house context in the brain while memorizing the objects. The results revealed that participants created associations between each memorized object and its implicit context solely due to the neurofeedback manipulation. Our findings shed light onto how memory formation can be influenced by synthetic memory tags with neurofeedback and advance our understanding of mnemonic processing.
Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila
Authors: Tikhonova Evgeniya , Mariasina Sofia , Efimov Sergey , Polshakov Vladimir , Maksimenko Oksana , Georgiev Pavel , Bonchuk Artem 
Published: February 2022

ABSTRACTTranscriptional regulators select their targets from a large pool of similar genomic sites. The binding of the Drosophila dosage compensation complex (DCC) exclusively to the male X chromosome provides insight into binding site selectivity rules. Previous studies showed that the male-specific organizer of the complex, MSL2, and ubiquitous DNA-binding protein CLAMP directly interact and play an important role in the specificity of X chromosome binding. Here we studied the highly specific interaction between the intrinsically disordered region of MSL2 and the N-terminal zinc-finger C2H2-type (C2H2) domain of CLAMP. We obtained the NMR structure of the CLAMP N-terminal C2H2 zinc finger, which has a classic C2H2 zinc-finger fold with a rather unusual distribution of residues typically used in DNA recognition. Substitutions of residues in this C2H2 domain had the same effect on the viability of males and females, suggesting that it plays a general role in CLAMP activity. The N-terminal C2H2 domain of CLAMP is highly conserved in insects. However, the MSL2 region involved in the interaction is conserved only within the Drosophila genus, suggesting that this interaction emerged during the evolution of a mechanism for the specific recruitment of the DCC on the male X chromosome in Drosophilidae.
“It’s allowed us access to the outside world”: A Qualitative Study of Lifespan Supported Mobility Device Use in Cerebral Palsy
Authors: Feldner Heather A. , Gaebler-Spira Deborah , Awasthi Varun , Bjornson Kristie 
Published: February 2022

AbstractAimThe overarching aim of this research was to 1) Understand the mobility experiences, supported mobility device (SMD) use, and desired participation outcomes of people with cerebral palsy (CP) across the lifespan; and 2) Describe how perspectives of rehabilitation care and professional resources may influence mobility decision-making processes and outcomes. The aim of this study was to understand the lived experience of SMD provision and use with a focus group guide co-developed by stakeholders.MethodsFocus groups were conducted with 164 participants (people with CP, caregivers, and healthcare providers) across four US cities. Sessions were audio-recorded, transcribed, and analyzed using constant comparison.ResultsSix themes emerged. Five presented across all stakeholder groups: 1) The System is Broken; 2) Equipment is Simultaneously Liberating and Restricting; 3) Adaptation Across the Lifespan; 4) Designed for Transport, not for Living; and 5) Sharing Our Stories and Sharing Resources. One theme was specific to healthcare provider groups: Caught in the Middle.InterpretationThis qualitative study underscores the simultaneous value and frustration associated with SMD, and the need to improve connections and resource networks within the CP community to improve SMD design and provision processes across device types and across the lifespan for people with CP.What this paper addsOne of the largest qualitative data sets specific to supportive mobility devices across ages and functional levels.Results indicate SMD is most often equated with freedom, participation, and independence.Frustrations with SMD across the lifespan persist related to design, function, cost, and maintenance.Stakeholders in the CP community are seeking greater networking and resource-sharing to enhance SMD provision processes.Access to appropriate SMD across the lifespan and the need for systems improvement is critical.
Providing a framework for post-disaster resilience factors in buildings and infrastructure from end-users’ perspectives: case study in Caribbean island states
Authors: Charles Shawn Hezron , Chang-Richards Alice , Yiu Tak Wing 
Published: February 2022

PurposeThe purpose of this paper is to elicit the expectations for resilient post-disaster rebuilds from Caribbean project end-users. In anticipation of future climatological, meteorological, hydrological or geophysical disasters disaster, key stakeholders can articulate and incorporate strategies for resilience development, thus leading to improved end-users’ satisfaction and confidence.Design/methodology/approachThis paper engages the results of a systematic literature review that identified 24 empirical resilience factors for post-disaster reconstruction projects. These factors informed a semi-structured questionnaire to elicit the perspectives of Caribbean end-users on a seven-point Likert scale. The quantitative analysis of both factor ranking and principal component analysis was performed to identify correlations and provides further interpretations on the desires of the end-users for resilient rebuilds.FindingsThe results presented in this paper highlight the collective perspectives on the Caribbean end-users on what they perceived to be aiding more resilient reconstruction projects. They identified reconstruction designs mindful of future hazards, policies that aid climate change mitigation, active assessment of key structures, readily available funding sources and ensuring stakeholder’s unbiased interest as the top-most empirical factors. Factor analysis suggested collaborations with inclusive training and multi-stakeholder engagement, critical infrastructure indexing and effective governance as the critical resilience development factors.Originality/valueTo the best of the authors’ knowledge, this paper is first of its kind to explore the perspective of the Caribbean people regarding disaster reconstruction projects. It addresses developmental avenues for measurement indicators towards resilience monitoring and improvement. Additionally, the perspectives can provide construction industry professionals with tools for improved operational resilience objective-setting guidance, for Caribbean construction.
Climatic disasters within a flood-prone coastal slum in Lagos: coping capacities and adaptation prospects
Authors: Adegun Olumuyiwa Bayode 
Published: February 2022

Purpose
Climate impacts are a significant challenge in slums and informal settlements, most of which are located along the coast. This article aims to show coping strategies and flood adaptation opportunities through the case study of a coastal slum in Lagos, Nigeria.

Design/methodology/approach
A mixed-method approach is used in Idi-Araba settlement, Oworonshoki, Lagos – the case study area. Data collection involved semi-structured interviews with 15 purposively selected residents and a survey (sample size = 300 residents). A town hall meeting was convened to disseminate the findings and gather feedback from the community.

Findings
Being an informally developed settlement, flooding affects the poor-quality buildings – a situation made worse by absence of infrastructure and services. Coping with flooding involves structural strategies (raising building’s foundation, re-roofing, sand-filling the surrounding, etc.), failed attempt through green infrastructure, nonstructural measures through dietary pattern, dressing, etc. These measures emanate from self-help and community efforts, attesting to notable social capital in the study area. They are minimally effective and limited, which highlights adaptation gaps and opportunities.

Research limitations/implications
This study calls for transformative adaptation, beyond the current coping and maladaptation. It argues that local strategies need to meet with innovative substantive external initiatives from the state and third sector.

Originality/value
This study considers the single case of a coastal settlement in Lagos. This focus allowed detailed examination within a representative settlement, much unlike city-wide, cross-settlement considerations in many other studies. It provides additional empirical evidence on limitations of self-help flood coping measures and adaptation prospects in the often overlooked low-income, informal urban sector.
A digital business model: an illustrated framework from the cultural heritage business
Authors: Russo-Spena Tiziana , Tregua Marco , D'Auria Anna , Bifulco Francesco 
Published: February 2022

PurposeThe paper offers a comprehensive understanding of how digital transformation affects business models and how firms operate and compete effectively and successfully in a digital economy.Design/methodology/approachThe research adopted an abductive approach (Dubois and Gadde, 2002) through constant movement between theory and empirical evidence. A systematic literature review led the first conceptual development and examples of practices from cultural heritage sectors were used in the theorizing process.FindingsThis paper depicts a digital model framework through a set of assumptions about how an organization creates and delivers value in an interconnected way by orchestrating new interactive processes, and providing experience propositions to customers, and about how value is framed in terms of economic, social and cultural outcomes.Originality/valueThe study contributes to the scientific debate by discussing the role of digital business models as enhancements more rather than replacements of traditional business models; it frames a digital business model as consisting of three main pillars: value orchestration, experience propositions and value sharing.