bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Use of an Online Bilingual Dictionary in EFL Writing
Authors: Chen Yuzhen , Liu Suping 
Published: August 2022

Abstract
The study was an experimental endeavor to explore the use of an online bilingual dictionary in EFL writing by gauging its effect on writing scores, assessing its impact on lexical sophistication, and examining learners’ dictionary lookup behavior during writing. A class of EFL students (n=34) at a Chinese university were asked to write two English compositions, one without access to a dictionary and the other with the help of Bing.dict, one of the most popular online bilingual dictionaries in China. A screen recorder was installed to capture in real time the whole process of dictionary consultation and writing. Results indicate that the use of Bing.dict exerted a significantly negative effect on the overall composition scores and the component scores for content and language use, although it did help to increase the students’ lexical range as measured by the Lexical Frequency Profile. A variety of dictionary-based errors were committed in terms of lexicon, syntax and collocation due to the students’ inadequate dictionary use skills and the unsatisfactory quality of the dictionary for productive language use. A close examination of the screen recordings reveals that the students adopted a range of poor consultation strategies during writing. They were content to find an English equivalent to a Chinese lexical item without bothering to further check its meaning and usage. In addition, they tried in vain to find ready text translations for Chinese sentences or sentence fragments. Focusing on the unreliable web-crawled examples, very few of the students paid attention to the source dictionaries. Besides, most of them were prone to accept what was offered in the dictionary without independent thinking. The findings of the study show a rather disappointing picture of the use of an online bilingual dictionary for language production, suggesting that it is absolutely imperative to train EFL learners on dictionary use.
Anhedonia, Apathy, Pleasure, and Effort-Based Decision-Making in Adult and Adolescent Cannabis Users and Controls
Authors: Skumlien Martine , Mokrysz Claire , Freeman Tom P , Valton Vincent , Wall Matthew B , Bloomfield Michael , Lees Rachel , Borissova Anna , Petrilli Kat , Giugliano Manuela , Clisu Denisa , Langley Christelle , Sahakian Barbara J , Curran H Valerie , Lawn Will 
Published: August 2022

Abstract

Background
Cannabis use may be linked with anhedonia and apathy. However, previous studies have shown mixed results, and few have examined the association between cannabis use and specific reward sub-processes. Adolescents may be more vulnerable than adults to harmful effects of cannabis. This study investigated (1) the association between non-acute cannabis use and apathy, anhedonia, pleasure, and effort-based decision-making for reward; and (2) whether these relationships were moderated by age group.

Methods
We used data from the “CannTeen” study. Participants were 274 adult (26–29 years) and adolescent (16–17 years) cannabis users (1–7 d/wk use in the past 3 months) and gender- and age-matched controls. Anhedonia was measured with the Snaith-Hamilton Pleasure Scale (n = 274), and apathy was measured with the Apathy Evaluation Scale (n = 215). Effort-based decision-making for reward was measured with the Physical Effort task (n = 139), and subjective wanting and liking of rewards was measured with the novel Real Reward Pleasure task (n = 137).

Results
Controls had higher levels of anhedonia than cannabis users (F1,258 = 5.35, P = .02, η p2 = .02). There were no other significant effects of user-group and no significant user-group*age-group interactions. Null findings were supported by post hoc Bayesian analyses.

Conclusion
Our results suggest that cannabis use at a frequency of 3 to 4 d/wk is not associated with apathy, effort-based decision-making for reward, reward wanting, or reward liking in adults or adolescents. Cannabis users had lower anhedonia than controls, albeit at a small effect size. These findings are not consistent with the hypothesis that non-acute cannabis use is associated with amotivation.
Motivic Rigidity for Smooth Affine Henselian Pairs over a Field
Authors: Druzhinin Andrei 
Published: August 2022

AbstractLet $Z\to X$ be a closed immersion of smooth affine schemes over a field $k$, and let $X^h_Z$ denote the henselisation of $X$ along $Z$. We prove that $E(X^h_Z)\simeq E(Z)$ for every additive presheaf $E\colon \textbf {SH}(k)^{\textrm {op}}\to \textrm {Ab}$ on the stable motivic homotopy category over $k$ that is $l_\varepsilon $-torsion or $l$-torsion, where $l\in \mathbb Z$ is coprime to $\operatorname {char} k$, and $l_\varepsilon =\sum _{i=1}^n \langle (-1)^i \rangle $. More generally, the isomorphism holds for any homotopy invariant $l_\varepsilon $-torsion or $l$-torsion linear $\sigma $-quasi-stable framed additive presheaf on $\textrm {Sm}_{k}$. This generalises the result known earlier for local schemes. We prove the above isomorphism by constructing (stable) ${\mathbb {A}}^1$-homotopies of motivic spaces via algebraic geometry. To achieve this, we replace Quillen’s trick with an alternative and more general construction that provides relative curves required in our setting.
Around the Combinatorial Unit Ball of Measured Foliations on Bordered Surfaces
Authors: Borot Gaëtan , Charbonnier Séverin , Delecroix Vincent , Giacchetto Alessandro , Wheeler Campbell 
Published: August 2022

Abstract
The volume $\mathcal {B}_{\sum }^{\textrm {comb}}({\mathbb {G}})$ of the unit ball—with respect to the combinatorial length function $\ell _{{\mathbb {G}}}$—of the space of measured foliations on a stable bordered surface $\sum $ appears as the prefactor of the polynomial growth of the number of multicurves on $\sum $. We find the range of $s \in {\mathbb {R}}$ for which $(\mathcal {B}_{\sum }^{\textrm {comb}})^{s}$, as a function over the combinatorial moduli spaces, is integrable with respect to the Kontsevich measure. The results depend on the topology of $\sum $, in contrast with the situation for hyperbolic surfaces where [6] recently proved an optimal square integrability.
Country data on AMR in India in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome
Authors: Torumkuney Didem , Poojary Aruna , Shenoy Bhaskar , Nijhara Puja , Dalal Krunal , Manenzhe Rendani 
Published: August 2022

Abstract

Background
Antimicrobial resistance (AMR) is one of the biggest threats to global public health. Selection of resistant bacteria is driven by inappropriate use of antibiotics, amongst other factors. COVID-19 may have exacerbated AMR due to unnecessary antibiotic prescribing. Country-level knowledge is needed to understand options for action.

Objectives
To review the current situation with respect to AMR in India and initiatives addressing it. Identifying areas where more information is required will provide a call to action to minimize further rises in AMR and to improve patient outcomes.

Methods
National AMR initiatives, antibiotic use and prescribing in India, and availability of susceptibility data, in particular for the key community-acquired respiratory tract infection (CA-RTI) pathogens (Streptococcus pneumoniae and Haemophilus influenzae) were identified. National and international antibiotic prescribing guidelines for specific CA-RTIs (community-acquired pneumonia, acute otitis media and acute bacterial rhinosinusitis) commonly used locally were also reviewed, plus local antibiotic availability. Insights from a local clinician and clinical microbiologist were sought to contextualize this information.

Conclusions
Many initiatives have been launched since AMR was recognized as a national priority and organizations such as the Indian Academy of Paediatrics and the Global Antibiotic Resistance Partnership have worked to build awareness. The Indian Ministry of Health and Family Welfare published a 5 year national action plan on AMR. However, the burden of infectious disease and consumption of antibiotics in India is high. There have been national surveillance studies generating local data along with international studies such as Survey of Antibiotic Resistance (SOAR) and Antimicrobial Testing Leadership and Surveillance (ATLAS). For common RTIs, clinicians use a range of international and national guidelines. However, a more standardized inclusive approach to developing local guidelines, using up-to-date local surveillance data from community-acquired infections, could make guidelines more locally relevant. This would encourage more appropriate antibiotic prescribing and improve adherence. This would, in turn, potentially limit AMR development and improve patient outcomes.
Nonspecific deidentification of date-like text in deidentified clinical notes enables reidentification of dates
Authors: Alexander Jes , Beatty Alexis 
Published: August 2022

Abstract
To facilitate the secondary usage of electronic health record data for research, the University of California, San Francisco (UCSF) recently implemented a clinical data warehouse including, among other data, deidentified clinical notes and reports, which are available to UCSF researchers without Institutional Review Board approval. For deidentification of these notes, most of the Health Insurance Portability and Accountability Act identifiers are redacted, but dates are transformed by shifting all dates for a patient back by the same random number of days. We describe an issue in which nonspecific (ie, excess) transformation of nondate, date-like text by this deidentification process enables reidentification of all dates, including birthdates, for certain patients. This issue undercuts the common assumption that excess deidentification is a safe tradeoff to protect patient privacy. We present this issue as a caution to other institutions that may also be considering releasing deidentified notes for research.
Response of the reproductive fitness and population density of Gammarus fossarum Koch, 1836 (Amphipoda: Gammaridae) to damming: a case study from the dammed sub-mountain stretch of Čierny Váh River, Slovakia
Authors: Kokavec Igor , Beracko Pavel 
Published: August 2022

Abstract
The plasticity of some biological and ecological characteristics of Gammarus fossarum Koch, 1836, a species widely distributed in the rivers of continental Europe, has been the subject of many scientific studies. The effects of river damming are reflected in the disruption of the natural environmental continuum of rivers, which has been demonstrated in this and other studies. We aimed to investigate the variability of population characteristics (relative reproductive fitness, pairing success, and fecundity), and population density in six local populations distributed along Čierny Váh River, Slovakia, a sub-mountain dammed river. Our results showed that the population inhabiting the site immediately downstream of the reservoir had significantly higher density, but its individuals had lower body size, pairing success, and fecundity compared to individuals at the other sites. As a result, the lower values of these characteristics were reflected in a different distribution pattern of relative reproductive fitness among individuals at the sites. Individuals at sites downstream of the reservoir, particularly those immediately below the reservoir, had lower mean fitness values. Our study demonstrated that the disturbance in the river environment caused by the dam not only affects the structure of the aquatic community, but can also alter population-level characteristics.
A novel design framework of synthetic radial aperture focusing for volumetric transrectal ultrasound imaging
Authors: Song Hyunwoo , Kang Jeeun , Boctor Emad M 
Published: August 2022

Abstract
In this paper, we present a novel design framework of synthetic radial aperture focusing for three-dimensional (3D) transrectal ultrasound imaging (TRUS-rSAF), in which multiple transmittance/reception events at different scanning angles are synthesized to reconstruct a radial plane in the target volume, securing high spatial resolution and texture uniformity. A theory-based design approach has not been available to push the envelope of the 3D rSAF technique. Herein, a closed-form analytical description of the TRUS-rSAF method is presented for the first time, effectively delineating spatial resolution and grating lobe positions in the radial dimension of a TRUS transducer. We demonstrate a solid optimization workflow based on the theoretical foundation to improve its spatiotemporal resolution, grating lobe artifacts, and signal-to-noise ratio. A specific design criterion was considered to outperform a clinical 3D TRUS imaging as a reference (TRUS-REF), where each radial plane is reconstructed with a single transmittance/reception event using a motorized actuator. The optimized TRUS-rSAF method significantly enhanced spatial resolution up to 50% over the TRUS-REF method while providing clinically effective temporal resolution (2–8 volume/sec) with negligible grating lobe artifacts. The results indicate that the proposed design approach would enable a novel TRUS imaging solution in clinics.
Bumble Bee Breeding on Artificial Pollen Substitutes
Authors: Gekière Antoine , Michez Denis , Vanderplanck Maryse 
Published: August 2022

Abstract
Bumble bees are important pollinators for many temperate crops. Because of the growing demand for food from entomophilous crops, bumble bee colonies are commercially reared and placed in fields or greenhouses to guarantee sufficient pollination services. Besides, commercial colonies are increasingly used in laboratories for various bioassays under controlled conditions. For both usages, bumble bee colonies are commonly provided with sugar solution and honey bee-collected pollen pellets. However, the latter display several disadvantages since they may contain pollutants, pathogens, or toxic phytochemicals. Consequently, companies have developed pollen-free artificial diets to sustain colonies. Such diets are designed to boost worker health in the field, in complement of floral pollen collected by workers outside the colonies, but their suitability in ‘closed’ systems without access to floral pollen, such as in laboratory bioassays, is arguable. Here, we used microcolonies of the commercially important bumble bee Bombus terrestris L. (Hymenoptera: Apidae) to assess the suitability of five artificial pollen substitutes and three mixed diets. We also assessed the evaporation rate of the different diets as it could impact their suitability. At the end of the bioassays, microcolonies fed the artificial diets showed a reduced offspring development when compared to microcolonies fed natural pollen, which was partly offset by mixing these diets with natural pollen. By contrast, the artificial diets did not have deleterious effects on worker’s health. We discuss the potential nutritional and physical causes of artificial diets unsuitability for offspring development and encourage further research to accordingly establish appropriate pollen-free diets for bumble bee breeding.
Comparative Insecticide Uptake Characteristics of Chlorfenapyr Suggests an Additional Reason Why Bed Bugs (Hemiptera: Cimicidae) are so Difficult to Control
Authors: Kells Stephen A , Kells Alice M 
Published: August 2022

AbstractInsecticides interact with biochemical sites, disrupting homeostasis, leading to moribundity and death. Considering this process of intoxication, investigating insecticide uptake ensures an understanding of exposure profile. This study evaluated insecticide uptake by bed bugs, Cimex lectularius L., as affected by time and formulation, and a comparative uptake by German cockroaches, Blattella germanica (L.). Insects exposed to chlorfenapyr residues from two Phantom insecticide formulations (i.e., Aerosol and Suspended Concentrate (SC)) were solvent extracted and analyzed by GC-ECD. Chlorfenapyr uptake by bed bugs significantly increased with time, but the rate of external chlorfenapyr adsorption between the two formulations was not significantly different. However, initial exposure and uptake to the aerosol-treated versus SC-treated surfaces were significantly greater by 2.7x. Absorption-rates of chlorfenapyr residues inside the insect, associated with internal insect tissues or exoskeleton-bound, were significantly lower compared with external adsorption, with aerosol and SC formulations accumulating at 4.8x and 14.4x less, respectively. An unexpected formulation effect occurred with aerosol-treated papers and aging of residues. A reformulation of the aerosol provided a greater adsorption of chlorfenapyr at 19.1x that of the original formula after 2 hr. External versus internal uptake of chlorfenapyr by cockroaches was inverse to that seen in bed bugs, with greater chlorfenapyr absorption. Obstructing cockroach mouthparts prevented an internal uptake of chlorfenapyr and provided a similar exposure profile to bed bugs. This work demonstrates a need to evaluate insecticide uptake with formulation and insect morphology to maximize dose, especially in such a morphologically and environmentally isolated insect as the bed bug.
The Antennal Sensilla and Expression Patterns of Olfactory Genes in the Lower TermiteReticulitermes aculabialis(Isoptera: Rhinotermitidae)
Authors: Saba Noor us , Ye Chenxu , Zhang Wenxiu , Wu Taoyu , Wang Yijie , Zhang Xiaohan , Song Zhuanzhuan , Xing Lianxi , Su Xiaohong 
Published: August 2022

AbstractThe insect olfactory system plays pivotal roles in insect survival and reproduction through odor detection. Morphological and physiological adaptations are caste-specific and evolved independently in workers, soldiers, and reproductives in termites. However, it is unclear whether the olfactory system is involved in the division of labor in termite colonies. In the present study, the antennal sensilla of alates, workers, soldiers, nymphs, and larvae of the termite Reticulitermes aculabialis Tsai et Hwang ( Isoptera: Rhinotermitidae) were investigated. Transcriptomes were used to detect olfactory genes, and differential expression levels of olfactory genes were confirmed in various castes by qRT–PCR analysis. Nine types of sensilla were identified on the antennae of R. aculabialis, and soldiers possessed all 9 types. In 89,475 assembled unigenes, we found 16 olfactory genes, including 6 chemosensory protein (CSP) and 10 odorant-binding protein (OBP) genes. These OBP genes included 8 general odorant-binding protein genes (GOBPs) and 2 pheromone-binding protein-related protein (PBP) genes. Five CSP genes were more highly expressed in alates than in workers, soldiers, larvae, and nymphs, and the expression levels of CSP6 were significantly higher in nymphs. Seven GOBP and two PBP genes exhibited significantly higher expression levels in alates, and there were no significant differences in the expression levels of GOBP2 among workers, soldiers, alates, and larvae. These results suggest that alates, as primary reproductives, have unique expression patterns of olfactory genes, which play key roles in nuptial flight, mate seeking, and new colony foundation.
Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling
Authors: Wei Xiaoli , Zheng Lanping , Tian Yingpu , Wang Haibin , Su Youqiang , Feng Gensheng , Wang Chao , Lu Zhongxian 
Published: August 2022

ABSTRACT
In mammals, the growth and maturation of oocytes within growing follicles largely depends on ovarian granulosa cells (GCs) in response to gonadotropin stimulation. Many signals have been shown to regulate GC proliferation and apoptosis. However, whether the tyrosine phosphatase SHP2 is involved remains unclear. In this study, we identified the crucial roles of SHP2 in modulating GC proliferation and apoptosis. The production of both mature oocytes and pups was increased in mice with Shp2 specifically deleted in ovarian GCs via Fshr-Cre. Shp2 deletion simultaneously promoted GC proliferation and inhibited GC apoptosis. Furthermore, Shp2 deficiency promoted, while Shp2 overexpression inhibited, the proliferation of cultured primary mouse ovarian GCs and the human ovarian granulosa-like tumor cell line KGN in vitro. Shp2 deficiency promoted follicule-stimulating hormone (FSH)-activated phosphorylation of AKT in vivo. SHP2 deficiency reversed the inhibitory effect of hydrogen peroxide (H2O2) on AKT activation in KGN cells. H2O2 treatment promoted the interaction between SHP2 and the p85 subunit of PI3K in KGN cells. Therefore, SHP2 in GCs may act as a negative modulator to balance follicular development by suppressing PI3K/AKT signaling. The novel function of SHP2 in modulating proliferation and apoptosis of GCs provides a potential therapeutic target for the clinical treatment of follicle developmental dysfunction.
CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation
Authors: Zhang Yan , Daniel Emily A , Metcalf July , Dai Yuqiao , Reif Gail A , Wallace Darren P 
Published: August 2022

ABSTRACT
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of fluid-filled cysts, causing nephron loss and a decline in renal function. Mammalian target of rapamycin (mTOR) is overactive in cyst-lining cells and contributes to abnormal cell proliferation and cyst enlargement; however, the mechanism for mTOR stimulation remains unclear. We discovered that calcium/calmodulin (CaM) dependent kinase IV (CaMK4), a multifunctional kinase, is overexpressed in the kidneys of ADPKD patients and PKD mouse models. In human ADPKD cells, CaMK4 knockdown reduced mTOR abundance and the phosphorylation of ribosomal protein S6 kinase (S6K), a downstream target of mTOR. Pharmacologic inhibition of CaMK4 with KN-93 reduced phosphorylated S6K and S6 levels and inhibited cell proliferation and in vitro cyst formation of ADPKD cells. Moreover, inhibition of calcium/CaM-dependent protein kinase kinase-β and CaM, two key upstream regulators of CaMK4, also decreased mTOR signaling. The effects of KN-93 were independent of the liver kinase B1–adenosine monophosphate-activated protein kinase (AMPK) pathway, and the combination of KN-93 and metformin, an AMPK activator, had additive inhibitory effects on mTOR signaling and in vitro cyst growth. Our data suggest that increased CaMK4 expression and activity contribute to mTOR signaling and the proliferation of cystic cells of ADPKD kidneys.
Notes on the Occurrence of Abnormal Thoracic and Abdominal Banding in Culex territans Larvae (Diptera: Culicidae)
Authors: Verna Thomas N 
Published: August 2022

Abstract
Pale-banded variants of Culex territans Walker larvae were found in southern New Jersey in 2016 and in subsequent years. The larvae lacked pigmentation on the prothoracic and mesothoracic segments as well as on abdominal segment (IV). The amount of pigmentation varied between populations. Specimens were found in six locations within a 5-yr period; of which, two locations recurred within the same season and in subsequent seasons. This is the first report in the State of New Jersey despite extensive larval surveillance over many years among the study area.