bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approaches to nutrition intervention in plaque psoriasis, a multi‐system inflammatory disease—The Diet and Psoriasis Project (DIEPP)
Authors: Zanesco Sylvia , Hall Wendy , Gibson Rachel , Griffiths Christopher , Maruthappu Thiviyani 
Published: September 2022

AbstractPsoriasis is an immune‐mediated inflammatory skin disease affecting approximately 2% of the UK population. Its pathogenesis is suggested to be an outcome of genetic and environmental interplay. People with psoriasis have an increased likelihood of developing other conditions such as type 2 diabetes and cardiovascular disease. Systemic inflammation is hypothesised to be the common link between psoriasis and cardio‐metabolic diseases. Emerging evidence shows diet as a potential therapeutic adjunct in the management of psoriasis. TheDiet and Psoriasis Project(DIEPP) aims to investigate whether dietary factors are related to psoriasis severity by conducting an observational study followed by a dietary intervention trial, to assess the effect of the Mediterranean diet (MedD) and time‐restricted eating (TRE) on psoriasis. This review article will explore the potential mechanisms by which the MedD and TRE may exert protective effects on psoriasis, evaluate the current evidence, and outline the design of the DIEPP. Given the early‐stage evidence, we hope to be able to build knowledge to derive medically approved dietary recommendations and contribute to the research gaps exploring the role of diet and psoriasis.
Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients
Authors: Hay Peter D. , Corsetti Maura , Tucker Emily , Fox Mark R. , Perkins Alan 
Published: September 2022

AbstractBackgroundScintigraphy is used for overall assessment of gastric emptying. Adherence to an international consensus protocol is recommended to ensure quality; however, this has not been widely adopted because preparation of the “egg‐beater” meal is inconvenient in clinical practice. In this report, we audit the tolerability and the results of gastric emptying scintigraphy with the 400 ml Tc‐99 m‐labeled liquid nutrient Nottingham Test Meal (NTM).MethodsResults from 330 consecutive adult, non‐diabetic patients with dyspeptic symptoms referred for gastric scintigraphy were analyzed. Gastric half‐emptying time (T50) and validated measurements of early‐ and late‐phase gastric emptying were acquired. Postprandial sensations of fullness, bloating, heartburn, nausea, and epigastric pain were recorded using 100 mm visual analog scales (VAS) before and 0, 30, and 90 min after NTM ingestion. Results were compared with those previously obtained in healthy subjects.Key ResultsAlmost all (98%) of the patients were able to consume the 400 ml NTM. Considering early‐ and late‐phase gastric emptying, frequently observed patterns included normal early‐ with slow late‐phase (25%) and fast early‐ with slow late‐phase emptying (27%). Abnormal score of fullness and/ or dyspeptic symptoms were observed in 88% of dyspeptic patients. Abnormal fullness at T0 (after completed drink ingestion) was associated with slow late phase of gastric emptying, especially in women.ConclusionsGastric scintigraphy with the NTM is simple to perform and well tolerated. Whether the identified abnormal gastric emptying patterns could predict different treatment outcome in patients with functional dyspepsia is the subject of ongoing prospective studies.
Verification of the Mandarin Chinese version of Advance Care Planning Engagement Survey Scale in community‐dwelling older people
Authors: Liu Dongling , Zhang Lingli , Li Jiayin , Wang Zicheng , Liu Xuebing , Zhang Qiongwen 
Published: September 2022

AbstractBackgroundAdvance care planning (ACP) has become increasingly critical for older people. The Advance Care Planning Engagement Survey (ACPES) develops targeted interventions for older people by measuring ACP‐related behaviours, while previous studies focus only on advance directives. Moreover, while ACPES has English and Dutch versions, it does not yet have a Mandarin Chinese version (ACPES‐MC) that can be used for Chinese populations.ObjectivesTo translate the ACPES into Mandarin Chinese and test its reliability and validity in community‐dwelling older people with chronic diseases.MethodsThe English version of the ACPES was translated into Mandarin Chinese using Functional Assessment of Chronic Illness Therapy. Four communities were recruited in central China (N = 450) by convenience sampling. Internal consistency and construct validity were used to evaluate the reliability and validity of the ACPES‐MC.ResultsThe ACPES‐MC consists of 34 items across five domains, with good internal consistency (0.817), with each dimension ranging from 0.606 to 0.881; exploratory factor analysis was distributed to four different factors and the total variance explained was 63.537%; and confirmatory factor analysis results showed that χ2 = 3791.131 (p < .001), χ2/df = 1.106, CFI = 0.980, IFI = 0.980, NFI = 0.827 and RMR = 0.027, indicating a good model fit to previous factor structures.ConclusionsThe ACPES‐MC is an effective and reliable tool that can measure the ACP‐related behaviour stage of community‐dwelling older people and evaluate the effect of ACP intervention.Implications for practiceThe ACPES‐MC can be used in healthcare to identify potential ACP‐related behaviours in community‐dwelling older people with chronic diseases, including native and ethnic Chinese, evaluate their behaviour change stages and promote the application of ACP.
Impact of cybersecurity on operations and supply chain management: Emerging trends and future research directions
Authors: Kumar Subodha , Mallipeddi Rakesh R. 
Published: September 2022

The new age economy is primarily driven by Industry 4.0 and Industry 5.0, which facilitate smartification of organizations by helping them integrate and automate decision making. Recent advances in information and communication technologies, such as the cloud, big data, Internet of things, and artificial intelligence and nanotechnology, have accelerated the adoption of Industry 4.0 and Industry 5.0. Because of these advancements, organizations are now facing new challenges in the form of cybersecurity risks that are partly caused by these technologies. In recent years, there has been a spike in the number of cyberattacks, and organizations are taking steps to minimize the impacts of these attacks. To address this critical issue, in this article, we discuss possible future research directions that production and operations management (POM) researchers can undertake to help organizations, supply chains, and governments develop robust strategies for reducing the number of attacks and their repercussions. In particular, we identify several avenues for future research in the following domains of POM: (1) global operations strategy, (2) healthcare operations management, (3) public policy, (4) management of technology, (5) supply chain management, and (6) disruptive technologies. Research on the topic of cybersecurity is not only an opportunity for operations management researchers but also critical for industry and society to overcome the challenges of cybersecurity risks.
Inferring sleep disturbance from text messages of suicide attempt survivors: A pilot study
Authors: Ladis Ilana , Valladares Tara L. , Coppersmith Daniel D. L. , Glenn Jeffrey J. , Nobles Alicia L. , Barnes Laura E. , Teachman Bethany A. 
Published: September 2022

AbstractObjectiveIdentifying digital markers of sleep disturbance—a known suicide risk factor—may aid in the detection of imminent suicide risk. This study examined sleep‐related communication and texting patterns in personal text messages (N = 86,705) of suicide attempt survivors.MethodTwenty‐six participants provided dates of past suicide attempts and 2‐week periods of positive mood, depressed mood, or suicidal ideation. Linguistic Inquiry Word Count was used to identify sleep‐related texts via a custom dictionary. Mixed effect models were fitted to test the association between suicide/mood episode type (e.g., attempt versus ideation) and three outcomes: likelihood of a text including sleep‐related content, nightly count of texts sent from midnight to 5:00 AM, and sum of unique hour bins from midnight to 5:00 AM with outgoing texts.ResultsAnalyses with a sleep dictionary that was manually revised to be more accurate (but not the original unedited dictionary) showed sleep‐related communication was more likely during depressed mood episodes than positive mood episodes. Otherwise, there were no significant differences in sleep‐related communication or objective texting patterns across episode type.ConclusionsAlthough we did not detect differences in sleep‐related communication tied to suicidal thoughts or behaviors, sleep‐related communication may differ as a function of within‐person mood level.
Evaluation of blood thiamine concentration in hospitalized dogs with and without critical illness
Authors: Lane Selena L. , Dowgos Nicole M. , Brainard Benjamin M. 
Published: September 2022

AbstractObjectiveTo evaluate blood thiamine concentration in healthy and critically ill hospitalized dogs over 72 hours of hospitalization and to identify any association of thiamine concentration with patient morbidity and mortality.DesignProspective, observational, clinical study.SettingUniversity veterinary teaching hospital.AnimalsThirty‐one hospitalized healthy dogs and 37 dogs with critical illness. Dogs with critical illness had nonseptic (n = 24) or septic (n = 13) etiologies.InterventionsNone.Measurements and Main ResultsWhole blood EDTA samples were collected within 24 hours of admission and 72 hours later. Samples were stored at –80°C and batch analyzed. Total thiamine (tB1) and thiamine diphosphate (TDP) concentrations were measured using high‐performance liquid chromatography, and free thiamine concentration was determined using liquid chromatography with tandem mass spectrometry. Collected patient data included CBC, biochemistry profile, plasma lactate concentration, shock index, Acute Patient Physiologic and Laboratory Evaluation Score (APPLEfast) score, comorbid conditions, and patient outcome. Approximately 92% of tB1 present in whole blood is measured as TDP. TDP concentration was strongly correlated with tB1 (R = 0.97, P < 0.0001). Thiamine concentration, represented by TDP, was not different at admission or at 72 hours in all dogs. TDP concentration was lower in septic dogs requiring surgery at admission (P = 0.044) and 72 hours later (P = 0.008), compared to dogs not requiring surgery. TDP concentration was not different between dogs with and without stable chronic diseases at any time point. Older dogs had lower TDP concentration. Positive correlations were seen between TDP and body weight, APPLEfast score, and WBC count. Critically ill dogs with lower admission plasma lactate concentration were more likely to have an increase in thiamine over time (P = 0.0142).ConclusionsDifferences in thiamine concentration were not identified in hospitalized healthy or critically ill dogs. Further investigation into the clinical relevance of thiamine deficiency is indicated in septic dogs undergoing surgery.
Comparison of clinical outcomes in cases of blunt, penetrating, and combination trauma in dogs: A VetCOT registry study
Authors: Davros Akaterina M. , Gregory Carly W. , Cockrell Darren M. , Hall Kelly E. 
Published: September 2022

AbstractObjectiveTo evaluate outcome (survival to discharge) among trauma types (blunt, penetrating, both) in dogs. The secondary objective was to evaluate if other trauma registry parameters differ between trauma types and influence survival.DesignRetrospective evaluation of veterinary trauma registry data.SettingVeterinary Committee on Trauma (VetCOT) identified Veterinary Trauma Centers (VTCs).AnimalsA total of 20,289 canine trauma patients with data entered in the VetCOT trauma registry from April 1, 2017 to December 31, 2019InterventionsNone.Measurements and Main ResultsData were obtained from the VetCOT database and included patient demographics, trauma type (blunt, penetrating, both), Animal Trauma Triage (ATT) score, modified Glasgow Coma Scale (mGCS), abdominal fluid score (AFS), loss of glide sign on thoracic focused assessment with sonography for trauma (TFAST), pleural effusion on TFAST, surgical procedure performed and in what location (emergency room vs operating room), and outcome. Data from 20,289 dogs were collected over a 30‐month period. The most common type of trauma was penetrating (10,816, 53.3%), followed by blunt (8360, 41.2%) and then combined blunt and penetrating trauma (1113, 5.5%). Dogs suffering only penetrating trauma had a 96.5% survival rate, blunt trauma had an 89.5% survival rate, and combined trauma had an 86.3% survival rate. Dogs suffering from both types of trauma had higher ATT scores, lower mGCS scores, and were more likely to be admitted to the ICU. Trauma type, mGCS, and ATT score were found to be associated with survival.ConclusionsThe present study highlights that dogs suffering from a combination of blunt and penetrating trauma are more likely to suffer moderate to severe injuries, have lower survival rates, and are more likely to be admitted to the ICU compared to dogs suffering from only blunt or penetrating trauma. Trauma type, mGCS, and ATT scores were found to be associated with survival in all groups.
The use of intralipid emulsion therapy to treat status epilepticus in a guinea pig (Cavia porcellus) secondary to severe ivermectin toxicity
Authors: Ebel Jennifer J. , Gannon Kristi , Kraenzlin Mara 
Published: September 2022

AbstractObjectiveTo describe the successful management of ivermectin‐induced status epilepticus in a guinea pig (Cavia porcellus) with intravenous lipid emulsion (ILE) therapy.Case SummaryA 5‐week‐old, female intact guinea pig was presented to an emergency hospital for status epilepticus 24 hours after oral administration of ivermectin. Approximately 48 hours after exposure, ILE therapy was administered. Within 12–16 hours after ILE therapy, seizures had stopped and the patient's mentation returned to normal. The definitive diagnosis was based on owner history, clinical presentation, and American Society for the Prevention of Cruelty to Animals poison control guidelines.New or Unique Information ProvidedThe use of intralipid therapy has been widely documented as a treatment option for numerous toxicities. Its efficacy in treatment for toxicities in both veterinary and human medicines has been well described in various case reports and studies. However, its use and success in small mammals have yet to be documented. In this case report, intralipid therapy is used to successfully treat a seizuring guinea pig that was administered a severely toxic dose of ivermectin. To the authors’ knowledge, this is the first report on the successful use of intralipids in a guinea pig from ivermectin toxicosis.
Geospatial data in pediatric asthma in the United States: a scoping review protocol
Authors: Cushing Anna M. , Khan Masrur A. , Kysh Lynn , Brakefield Whitney S. , Ammar Nariman , Liberman Danica B. , Wilson John , Shaban-Nejad Arash , Espinoza Juan 
Published: September 2022

ABSTRACT

Objective:
The objective of this scoping review is to identify and describe the literature on the use of geospatial data in pediatric asthma research.

Introduction:
Asthma is one of the most common pediatric chronic diseases in the United States, disproportionately affecting low-income patients. Asthma exacerbations may be triggered by local environmental factors, such as air pollution or exposure to indoor allergens. Geographic information systems are increasingly recognized as tools that use geospatial data to enhance understanding of the link between environmental exposure, social determinants of health, and clinical outcomes. Geospatial data in pediatric asthma may help inform risk factors for asthma severity, and guide targeted clinical and social interventions.

Inclusion criteria:
This review will consider studies that utilize geospatial data in the evaluation of pediatric patients with asthma, ages 2 to 18 years, in the United States. Mixed samples of adults and children will also be considered. Geospatial data will include any external non-clinical geographic-based data source that uses a patient's environment or context.

Methods:
The following databases will be searched: PubMed, Embase, Cochrane CENTRAL, CINAHL, ERIC, Web of Science, and IEEE. Gray literature will be searched in DBLP, the US Environmental Protection Agency, Google Scholar, Google search, and a hand search of recent abstracts from relevant conferences. Articles published in English, Spanish, and French from 2010 to the present will be included. Study screening and selection will be performed independently by two reviewers. Data extraction will be performed by a trained research team member following pilot testing.
Barriers to and facilitators for low dose computed tomography lung cancer screening in rural populations in the United States: a scoping review protocol
Authors: Palokas Michelle , Hinton Elizabeth , Duhe Roy , Christian Robin , Rogers Deirdre , Sharma Manvi , Stefanek Michael 
Published: September 2022

ABSTRACT

Objective:
The objective of this scoping review is to identify barriers to and facilitators for low dose computed tomography lung cancer screening uptake and adherence among rural populations in the United States.

Introduction:
Lung cancer is the leading cause of cancer-related death in the United States and cancer patients from rural areas have poorer outcomes than those from metropolitan areas. Evidence exists that lung cancer screening by low dose computed tomography significantly impacts survival time but is also significantly underutilized.

Inclusion criteria:
Studies completed in the United States with adults who fit United States Preventive Services Task Force guidelines for lung cancer screening and who live in rural areas will be included. Studies published in English since 2013 that report on barriers to and facilitators for low dose computed tomography lung cancer screening uptake and adherence will be included in this review. Quantitative, qualitative, or mixed-methods studies will be included, along with opinion pieces published by government agencies or professional cancer-related organizations.

Methods:
The search strategy will locate published primary studies, reviews, and opinion papers, including those by government and nonprofit agencies focused on cancer. The databases to be searched include MEDLINE, CINAHL Complete, Embase, Web of Science, and Cochrane Library. Gray literature databases and sources for unpublished studies will also be searched. Independent reviewers will be used throughout the search and selection process.
Public health approaches to substance use: a scoping review protocol
Authors: Kosteniuk Brynn , Speed Kelsey , Candler Ethan , Campbell Sandy , Penney Greg , Moen Karin , Hyshka Elaine 
Published: September 2022

ABSTRACT

Objective:
The aim of this scoping review is to describe how a public health approach to legal and illegal psychoactive substance use has been previously defined, and to identify its core values, concepts, activities, and goals.

Introduction:
Jurisdictions globally are increasingly endorsing a public health approach to addressing psychoactive substance use. However, there is currently no agreed definition of this approach, and this term has been applied inconsistently in the literature, policy, and practice. A critical first step toward advancing a public health approach to substance use is identifying and articulating its core components.

Inclusion criteria:
This review will consider all peer-reviewed and gray literature in English focused on conceptualizing, defining, or describing a public health approach to substance use. Our review does not place limitations on populations, psychoactive substance types, or other contextual factors.

Methods:
We will search PROSPERO, MEDLINE, Embase, PsycINFO, Cochrane Library, CINAHL, and Scopus, as well as health and social science databases; websites of prominent nonprofit, civil society, and government agencies/organizations in public health and substance use fields; and reference lists of included articles. Two independent reviewers will screen titles/abstracts of peer-reviewed literature, and 1 reviewer will screen titles/abstracts of gray literature. Two independent reviewers will conduct the full-text screening. A data extraction sheet will be pilot tested through double extraction. Findings will be presented as a narrative summary supported by tables and diagrams and, if feasible, a conceptual framework for understanding and applying a public health approach to substance use.

Scoping review registration number:
Open Science Framework https://osf.io/sv25e
Histone deacetylase inhibitor use as a radiosensitizer in solid organ malignancies: a systematic review protocol
Authors: Sullivan Jessica , Feng Zhihui , Fahey Paul , Agho Kingsley , Hurley Simon , Lim David 
Published: September 2022

ABSTRACT

Objective:
The objective of this review is to evaluate the efficacy and adverse effects of histone deacetylase inhibitors (HDACi) in combination with radiotherapy for the treatment of solid organ malignancies.

Introduction:
Histone deacetylase inhibitors are a diverse class of drugs that have shown promise as novel anti-cancer therapeutics via epigenetic modification and radiosensitization of neoplastic cells. The aim of HDACi in combination with radiotherapy is to reduce radiation dosage requirements, improve radiotherapy efficacy, and reduce treatment side effects.

Inclusion criteria:
This review will consider studies utilizing HDACi in conjunction with radiotherapy in adult patients with solid organ malignancy. Sources to be included in this review include experimental and quasi-experimental study designs, analytical studies, and descriptive observational studies.

Methods:
A systematic review of effectiveness will be conducted in accordance with JBI methodology. A detailed search will be conducted via MEDLINE (Ovid), Embase (Ovid), and Scopus. A search of the Cochrane Central Register of Controlled Trials, the International Clinical Trials Registry Platform, and ClinicalTrials.gov will also be performed for relevant trials. Inclusion and exclusion criteria will be utilized to select studies, and papers selected for retrieval will be assessed for methodological validity using the JBI critical appraisal instruments. Evidence will be extracted from eligible studies and summarized using quantitative methods, where possible, including meta-analysis and assessment of heterogeneity. Where statistical pooling is not possible, the findings will be presented in diagrammatic or tabular form accompanied by a narrative summary.

Systematic review registration number:
PROSPERO CRD42021293005