bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia
Authors: Elsaid Khaled , Merriman Tony R. , Rossitto Leigh‐Ana , Liu‐Bryan Ru , Karsh Jacob , Phipps‐Green Amanda , Jay Gregory D. , Elsayed Sandy , Qadri Marwa , Miner Marin , Cadzow Murray , Dambruoso Talia J. , Schmidt Tannin A. , Dalbeth Nicola , Chhana Ashika , Höglund Jennifer , Ghassemian Majid , Campeau Anaamika , Maltez Nancy , Karlsson Niclas G. , Gonzalez David J. , Terkeltaub Robert 
Published: December 2022

ObjectiveIn gout, hyperuricemia promotes urate crystal deposition, which stimulates the NLRP3 inflammasome and interleukin‐1β (IL‐1β)–mediated arthritis. Incident gout without background hyperuricemia is rarely reported. To identify hyperuricemia‐independent mechanisms driving gout incidence and progression, we characterized erosive urate crystalline inflammatory arthritis in a young female patient with normouricemia diagnosed as having sufficient and weighted classification criteria for gout according to the American College of Rheumatology (ACR)/EULAR gout classification criteria (the proband).MethodsWe conducted whole‐genome sequencing, quantitative proteomics, whole‐blood RNA‐sequencing analysis using serum samples from the proband. We used a mouse model of IL‐1β–induced knee synovitis to characterize proband candidate genes, biomarkers, and pathogenic mechanisms of gout.ResultsLubricin level was attenuated in human proband serum and associated with elevated acute‐phase reactants and inflammatory whole‐blood transcripts and transcriptional pathways. The proband had predicted damaging gene variants of NLRP3 and of inter‐α trypsin inhibitor heavy chain 3, an inhibitor of lubricin‐degrading cathepsin G. Changes in the proband's serum protein interactome network supported enhanced lubricin degradation, with cathepsin G activity increased relative to its inhibitors, SERPINB6 and thrombospondin 1. Activation of Toll‐like receptor 2 (TLR‐2) suppressed levels of lubricin mRNA and lubricin release in cultured human synovial fibroblasts (P < 0.01). Lubricin blunted urate crystal precipitation and IL‐1β induction of xanthine oxidase and urate in cultured macrophages (P < 0.001). In lubricin‐deficient mice, injection of IL‐1β in knees increased xanthine oxidase–positive synovial resident M1 macrophages (P < 0.05).ConclusionOur findings linked normouricemic erosive gout to attenuated lubricin, with impaired control of cathepsin G activity, compounded by deleterious NLRP3 variants. Lubricin suppressed monosodium urate crystallization and blunted IL‐1β–induced increases in xanthine oxidase and urate in macrophages. The collective activities of articular lubricin that could limit incident and erosive gouty arthritis independently of hyperuricemia are subject to disruption by inflammation, activated cathepsin G, and synovial fibroblast TLR‐2 signaling.image
How does the go‐with‐the‐flow export strategy affect corporate environmental performance?—Evidence from Chinese manufacturing firms
Authors: Yu Zhuangxiong , Cheng Jiajia , Shi Xunpeng , Yang Yang 
Published: December 2022

AbstractHow the export strategy affects corporate environmental performance (CEP) is an integral part of trade and environmental issue. This paper investigates the impact of the go‐with‐the‐flow export strategy on CEP during the period 2000 to 2013 by the Chinese Industrial Firms Green Production Emissions Database and the China Customs Database. The study shows that the go‐with‐the‐flow export strategy increases firms' pollution emissions, that is, the more the firms follow the market, the higher their SO2 emission intensity. However, this environmental degradation effect is only found in small and domestic‐owned firms. Furthermore, this study finds that the go‐with‐the‐flow export strategy could lead to a conservative production strategy and low survival pressure, which makes firms shortsighted in terms of less investment in clean innovation and sustainable production. Based on these empirical results, the government should reduce firms' cost of clean innovation and ameliorate the problem of market information asymmetry. Such efforts would allow firms to devote more resources to sustainable production rather than information gathering. In addition, environmental regulations should go hand in hand with the promotion of green technology to avoid the expelling effect of regulation and for firms' sustainable production.
Differential transform method for couple stress fluid flow in a channel with a porous base
Authors: Vyas Paresh , Gajanand  
Published: December 2022

AbstractThe paper presents an application of the semi‐analytical differential transform method (DTM) to thermofluidics of generalized Couette flow of couple stress fluid inside a composite channel. The channel comprises a fluid‐saturated porous layer and a clear fluid region. The flow is caused by a uniformly favorable pressure gradient applied at the mouth of the channel and the shear of the moving upper wall of the channel. The matching conditions are taken such that the velocity, temperature, and respective gradients are continuous at a clear fluid–porous medium. The problem is novel because this is the first mathematical endeavor to treat fluidic systems involving composite channels. Besides the mathematical rigor, it presents an analysis of thermodynamic irreversibility and other quantities of interest, viz, skin friction and Nusselt number. The results derived from DTM are compared with those obtained by exact solution showing excellent agreement. The plots and tables are drawn and discussed.
Dealing with pancreatitis in cats and dogs
Authors: Rogers‐Smith Emma 
Published: December 2022

Background: Pancreatitis can be challenging from a diagnostic and management point of view in both canine and feline patients.Aim of the article: This article considers the differences in anatomy and pathophysiology between dogs and cats and discusses a practical approach to these cases in the clinic. It also highlights when it's appropriate to manage these cases the same way, as well as the critical times when clinicians should remember that cats aren't just small dogs.
Examining self‐efficacy and COVID‐19 disease prevention behaviors among socially vulnerable populations
Authors: Mace Firebaugh Casey , Wojtyna Amie , Rich Debbie , Beeson Tishra 
Published: December 2022

AbstractSocial vulnerabilities are associated with higher COVID‐19 disease morbidity and mortality. Primary forms of COVID‐19 disease prevention aside from vaccination, are health behaviors including masking, hand washing, social distancing, and staying home when one is sick. Understanding the self‐efficacy of these behaviors in vulnerable populations can inform health interventions to improve COVID‐19 disease outcomes. A repeated cross‐sectional study with three waves (Wave 1 = pilot, Wave 2, n = 1258, Wave 3, n = 477) was conducted using an online survey. This analysis only included Wave 2 and Wave 3. The study targeted Yakima County, WA, USA, an area with pronounced social, environmental, and health disparities. Measures included demographic, household, and self‐efficacy constructs. Binary logistic regression was used to determine which demographic and household factors were related to constructs of self‐efficacy. An independent t‐test was performed to determine if there were significant differences between population levels of self‐efficacy over time (Wave 2 vs. Wave 3). Household size, identifying as Hispanic/Latino, and measures of socioeconomic status were significantly related to various self‐efficacy beliefs about COVID‐19 disease prevention behaviors and the ability to protect oneself from COVID‐19 disease in general. Self‐efficacy increased for each measure between Wave 2 and Wave 3 (p < 0.001). Socially vulnerable groups continue to experience disparate health outcomes in the face of COVID‐19 disease. Future studies should examine ways to increase self‐efficacy among populations that are experiencing lower levels as self‐efficacy is a significant factor related to health outcomes.
SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR‐ULK1 signaling, provoking pro‐viral autophagy
Authors: Feng Kuan , Zhang Huijiao , Jiang Zhenyu , Zhou Min , Min Yuan‐Qin , Deng Fei , Li Peiqing , Wang Hualin , Ning Yun‐Jia 
Published: December 2022

AbstractAutophagy is emerging as a critical player in host defense against diverse infections, in addition to its conserved function to maintain cellular homeostasis. Strikingly, some pathogens have evolved strategies to evade, subvert or exploit different steps of the autophagy pathway for their lifecycles. Here, we present a new viral mechanism of manipulating autophagy for its own benefit with severe fever with thrombocytopenia syndrome bunyavirus (SFTSV, an emerging high‐pathogenic virus) as a model. SFTSV infection triggers autophagy, leading to complete autophagic flux. Mechanistically, we show that the nonstructural protein of SFTSV (NSs) interacts with mTOR, the pivotal regulator of autophagy, by targeting its kinase domain and captures mTOR into viral inclusion bodies (IBs) induced by NSs itself. Furthermore, NSsimpairs mTOR‐mediated phosphorylation of unc‐51‐like kinase 1 (ULK1) at Ser757, disrupting the inhibitory effect of mTOR on ULK1 activity and thus contributing to autophagy induction. Pharmacologic treatment and Beclin‐1 knockout experimental results establish that, in turn, autophagy enhances SFTSV infection and propagation. Moreover, the minigenome reporter system reveals that SFTSV ribonucleoprotein (the transcription and replication machinery) activity can be bolstered by autophagy. Additionally, we found that the NSs proteins of SFTSV‐related bunyaviruses have a conserved function of targeting mTOR. Taken together, we unravel a viral strategy of inducing pro‐viral autophagy by interacting with mTOR, sequestering mTOR into IBs and hence provoking the downstream ULK1 pathway, which presents a new paradigm for viral manipulation of autophagy and may help inform future development of specific antiviral therapies against SFTSV and related pathogens.
Sensory analysis of microwave‐roasted fenugreek and coffee blend
Authors: Yazicioglu Nalan 
Published: December 2022

AbstractFenugreek is one of the well‐known legumes, used for its antimicrobial, antioxidant, nutritional, and pharmaceutical properties. It was aimed to obtain coffee by blending microwave (600 W)‐roasted fenugreek with coffee arabica and to determine the best roasting conditions (2 and 4 min), and blending ratios (20% and 50%) for fenugreek seeds by consumer sensory analysis. A voluntary, minimal‐trained consumer panel of 80 panelists was conducted. Coffee from roasted Arabica beans (100%) was used as a control. Cronbach's alpha values of 67.2% and 90.9% were obtained for the reliability of the first and second parts of the survey, respectively. The attributes “brown” color, “burnt,” and “bitter” taste, and “astringent” texture were significantly different between samples (p < 0.05), whereas oily appearance, green color, coffee, green/vegan, fruity, sour, sweet, nutty, caramel, cacao, caffeine and creamy flavor, and viscosity sensation were statistically the same. The Tamhane T2 post hoc test showed that the color of the control sample was more brownish, whereas the 50% blend of 4 min roasted fenugreek had a more burnt, bitter, and astringent taste. Appreciation scores for taste/aroma, appearance, and mouthfeel also differed significantly between samples, whereas odor was rated as the same by panelists. This study shows that sample with 20% mixture of fenugreek roasted for 4 min at 600 W had statistically the same scores as the control sample in terms of odor, appearance, aroma, taste, and mouthfeel. These findings were also supported by physical and antioxidative quality measurements such as color, pH, moisture content, total phenolic content, and antioxidant activity.
A survey to assess perspectives of people with chronic stroke about customized safety harnesses for dance‐based exergaming in home settings
Authors: Subramaniam Savitha , Wang Edward , Bhatt Tanvi 
Published: December 2022

AbstractBackgroundEarly dance‐based exergaming (DBExG) trials in people with chronic stroke (PwCS) have shown promising results, but there remains a lack of knowledge if PwCS are interested in receiving such training in their homes and the applicability of a fall‐protection safety harness in the home environment.ObjectiveTo survey people with chronic stroke to understand the perspectives and preferences of various customized safety harnesses for home‐based harness assisted dance‐based exergaming rehabilitation.MethodsParticipants were included in this survey study if they had a stroke, lived in the community, and understood English. Participants completed a study‐specific safety harness survey via mail, in‐person, or online. Descriptive statistics were used to characterize the sample and survey responses.ResultsOne hundred two survey responses were returned. The majority of participants voted for a door mountable harness (51%), side‐release style buckle (58%), and preferred to receive a manual to explain how to use the harness (51%). Seventy‐eight percent of the participants required permission to install or use a harness system in their homes. More than half of the participants preferred exhibiting independence by strapping the harness themselves (68%), along with choosing to live independently (the ability to live in one's own home and community safely, independently, comfortably, and able also perform their activities of daily living, regardless of physical ability level) (89%).ConclusionsPwCS opted to use ShA‐DBExG in their homes. The current survey serves as a guideline to develop, customize, and prescribe home‐based ShA‐DBExG rehabilitation.
Evaluation of different rainwater harvesting techniques for improved maize productivity in semi‐arid regions of Zimbabwe with sandy soils
Authors: Chiturike Pasipanodya , Nyamadzawo George , Gotosa Jephta , Mandumbu Ronald , Nyakudya Innocent Wadzanayi , Kubiku Friday Nguvayasvika Mudondo , Kugedera Andrew Tapiwa 
Published: December 2022

AbstractBackgroundMaize production in semi‐arid areas has been hindered by moisture stress and poor soil fertility. Long frequent droughts and shortening of growing seasons have been causing yield reduction. Limited knowledge of soil water management by farmers is another key contributor to poor maize yields in the smallholder sector. Therefore, the objective of the study was to investigate the effects of contour‐based and field‐based water harvesting technologies on maize grain yield and rainwater use efficiency under rain‐fed conditions on three farms (Jera, Kudzeeta and Manjengwa) with sandy soils in the Marange smallholder farming area of Zimbabwe. The experiment was laid out as a split plot in a randomised complete block design with three replications at each site. Contour‐based rainwater harvesting structures were the main treatments comprising tied contour (TC), standard contour (STDC) and infiltration pits (IP). Field‐based rainwater harvesting structures were the subplot treatments comprising tied ridges (TR), pot holing (PH) and the flat system (FLAT).ResultsResults showed that the contour‐based water harvesting structures significantly influenced (p < 0.05) maize grain yields. TCs had the highest maize grain yields compared with infiltration pits and STDCs over two cropping seasons. Maize yields on field‐based TR were significantly higher (p < 0.05) than on the FLAT but were not different (p > 0.05) with what was obtained on PH. The combination of TC and TR water harvesting technologies resulted in significantly higher maize yields (p < 0.05) than other combinations. TR and STDC also gave higher maize grain yield at Jera farm which was significantly different from other two farms. Rainwater use efficiency followed the same trend as maize grain yields, with TC having higher values but not significantly different (p > 0.05) from STDC.ConclusionIt can be concluded that farmers in semi‐arid areas adopt a combination of TC with either TR or PH to improve rainwater use efficiency and maize yields.
Design, Synthesis of New Pyrazoles and Chromenes as ERK‐2 Inhibitors, Apoptosis inducers and Cell cycle interrupters Based on Thiophene‐Chalcone Scaffold
Authors: Metwally Nadia Hanafy , Eldaly Salwa Magdy 
Published: December 2022

AbstractArylmethylene derivatives, chromenes and aminothiophenes were synthesized from 2‐cyano‐N‐(4‐(3‐(thiophen‐2‐yl)acryloyl)phenyl)acetamide 2. The anticancer activity of most synthetic compounds was assessed in breast cancer (MCF‐7), hepatocellular carcinoma (HepG‐2) and cervical cancer (HeLa), with five of arylmethylene and chromene derivatives showing highest cytotoxic activity. Further, treatment of breast cancer (MCF‐7) cell lines with 4 d and 6 b, the most cytotoxic compounds; revealed down regulation for ERK‐2 protein with expression concentration; 527.7±6.61 and 427.7±8.39 pg/ml, respectively compared to staurosporine; 440.9±5.02 pg/ml. Moreover, cell death induction was assessed by Annexin V‐ FITC/PI assay and these compounds caused cell death by apoptosis, besides the DNA fragmentation was assessed by gel electrophoresis and ELISA and the data showed increase in the percentage of fragmentation in treated MCF‐7 of values; 30.49 % and 28.19 % in 4 d and 6 b, respectively confirming the same effect as staurosporine. The DNA‐flow cytometric cell cycle analysis showed that 4 d and 4 g arrested the cell cycle at S phase and 8 b arrested it at G1/S phase. Molecular docking was carried out together with physicochemical properties prediction using DruLiTo program.
An Efficient Route for the Synthesis of 1,5‐Disubstituted Tetrazoles and their Anti‐Microbial Activity Against Salmonella Paratyphi
Authors: Preetham Ramesh , Vijaya Kumar Malahalli S. , Swaroop Toreshettahally R. , Divyashree S. , Kiran Kuppalli R. , Sreenivasa Marikunte Y. , Sadashiva Maralinganadoddi P. , Rangappa Kanchugarakoppal S. 
Published: December 2022

AbstractCarbimidothioates were synthesized by the reaction of Grignard reagents with arylisothiocyanates followed by methylation with methyl iodide. Further, these carbimidothioates were cyclized with sodium azide in DMF at 120 °C to get 1,5‐disubstituted tetrazoles, which are important class of compounds in medicinal chemistry. Hence, we evaluated the antibacterial activity against Salmonella Paratyphi bacteria. Among the series, compounds 6 a, 6 c, 6 f and 6 i effectively inhibited Solamonella Paratyphi. Compound 6 f performed well in the agar well diffusion experiment. Compound 6 i outperformed the standard drug in micro dilution assay and biofilm inhibition experiment using Crystal violet at 1 mM concentration. These studies demonstrates that active molecules are the most promising options for reducing S. paratyphi biofilm. In order to know the binding mode of the synthesized molecules, we performed molecular docking studies with protein Salmonella Paratyphi A lipopolysaccharide acetyltransferase periplasmic domain (PDB ID‐6SE1). Among the series, compounds 6 f and 6 i exhibited the most significant affinity score with 6SE1 protein.
Measuring Health-Related Quality of Life in Dementia
Authors: Smith Sarah C. 
Published: December 2022

AbstractDementia presents unique challenges for the measurement of health-related quality of life (HRQL). The subjective nature of the HRQL construct, the cognitive demands of questionnaires, and the necessity of sometimes relying on a proxy report taken together mean that traditional questionnaires scored using classical psychometrics may not provide robust measurement. Advanced psychometric methods, such as those based on Rasch measurement theory, can provide possible solutions to these challenges. Rasch based methods have been used with the DEMQOL/DEMQOL-Proxy disease specific HRQL instrument to measure HRQL in people with dementia, to provide robust scales, to equate self- and proxy-reported instruments, and to create a cross walk from a proxy-reported measurement to the equivalent self-reported measurement. These methods also provide a qualitative understanding of statistical change. Advanced psychometric methods such as those based on Rasch measurement theory therefore provide a potentially powerful way to address the challenges of measuring HRQL for people with dementia. However, the use of these methods is not a quick fix. They require careful development of a conceptual framework describing the construct (HRQL) and a commitment to keeping the person with dementia’s perspective central at all stages of the process.
Improving Clinical Practice with Person-Centered Outcome Measurement
Authors: Allen Diane D. , Pak Sang S. 
Published: December 2022

AbstractMeasurement choices play a critical role in improving healthcare systems. As this book describes, improved measurement can promote excellence in person-centered outcomes through health policy, methodology, theory, and clinical practice. This chapter focuses on measurement choices within clinical practice that can guide decision-making for improved outcomes. The overall objective is for clinical practice to deliver high-quality and equitable healthcare tailored to the unique situation of each specific person. Separate sections discuss the context surrounding measurement choices, specific dilemmas or competing priorities that affect measurement choices, and recommendations for improving person-centered outcome measurement.
An Adaptive Strategy for Measuring Patient-Reported Outcomes: Incorporating Patient Preferences Relevant to Cost-Benefit Assessments of Vision Rehabilitation
Authors: Massof Robert W. , Bradley Chris 
Published: December 2022

AbstractVision rehabilitation aims to improve daily functioning in patients with chronic disabling vision impairments – low vision – by providing vision assistive equipment and teaching patients effective use of the equipment; teaching patients adaptations to obviate dependence on vision; modifications of the patient’s environment to improve visibility and increase safety; and psychosocial counseling and education to help patients cope with the stress of impaired vision. The interventions that constitute vision rehabilitation are tailored to each patient’s functional goals and personal preferences. This chapter describes the theory, structure, and mechanics of an adaptive patient-reported outcome measure – the Activity Inventory (AI). The AI was developed to identify each patient’s unique set of functional goals within a hierarchical framework, to specify the cognitive and motor activities (i.e., tasks in different functional domains) the patient customarily performs to achieve his or her personal goals, and to elicit ordinal patient ratings of the importance and difficulty of each goal and the difficulty of relevant subsidiary tasks under goals that meet or exceed defined importance and difficulty criteria. The theoretical assumptions of a Rasch psychometric model that is employed to estimate measures of the patient’s overall visual ability from goal difficulty ratings and ability in each functional domain from task difficulty ratings before and after vision rehabilitation are presented and the results for a large group of low vision patients are reviewed. This chapter then explores the issue of how individual patient preferences must be factored into the outcome measures to determine the utility of functional improvements from vision rehabilitation. A theoretical framework for incorporating the utility of individual vision rehabilitation outcomes is offered and its application to functional outcome data is demonstrated.