bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Most Important Medicinal Herbs and Plants in Traditional Chinese
and Iranian Medicinal Sciences with Antioxidant Activities
Authors: Sun Wenli , Shahrajabian Mohamad Hesam , Cheng Qi 
Published: April 2022

Abstract:
The review is aimed at summarizing the most important and common natural antioxidants and
their resources from traditional Irani and Chinese medicinal sciences. The most important medicinal
plants with antioxidant activities in Iran are Artemisia, berberry fruit, borage, calendula, coriander, cumin,
green tea, hawthorn, jujube, pomegranate, rose, rosemary, black zira, tea, and thyme. Important traditional
medicinal plants with antioxidant activities in China are Asparagus, bindii, blueberries, camellia, Chinese
bayberry, Chinese bitter melon, Chinese cabbage, Chinese cherry, Chinese jujube, Chinese olive, pomegranate,
Chinese rose tea, Chinese toon, Chinese watermelon, black tea, knotweed, Chinese quince, Chinese
rhubarb, sumac, wolfberry, dendrobium, drumstick tree, Fiscus species, ginger, ginkgo, goji berry,
grape, Jerusalem thorn, kiwifruit seed oil, and licorice root. The present review article highlights the most
important medicinal plants which have been used in Iran and China as traditional herbal medicines for
hundreds of years due to their tremendous antioxidant activities.
Nutraceutical Approach to the Management of Cystic Fibrosis
Authors: Medithi Srujana , Chindarkar Manali 
Published: April 2022

Background:
Cystic fibrosis (CF) is an autosomal recessive monogenic disease
marked by a mutation in the cystic fibrosis transmembrane conductance regulator gene. Cystic
fibrosis transmembrane conductance regulator gene mutations affect respiratory, digestive and
reproductive functions and impede bicarbonate, bile acid, and sweat secretion. Moreover, the
current trend indicates that CF is no longer only a paediatric disease, but has progressively
become a disease that also affects adults. This calls for addressing the condition with an
appropriate nutraceutical approach.

Objective:
The study aims to find and collate nutritional targets in the management of cystic
fibrosis.

Method:
Studies highlighting the benefits of nutrients or nutraceuticals in the management of
cystic fibrosis were included from previously published research articles (1971 to 2020). Data
including nutrients, nutraceuticals, study design, study model, sample size, age, dose and
duration of the dose of the supplement were extracted from the studies included and explored to
understand their role.

Results:
About 26 studies were included in the present review. It was found that nutrient interventions
comprising nutraceuticals, including dietary fibre, proteins and amino acids (taurine,
arginine, glutathione), fats (medium-chain triglycerides, polyunsaturated fatty acids (omega-3
fatty acids), phytochemicals (apigenin, genistein, quercetin, curcumin, allicin, beta-carotene,
Pulmonaria officinalis L, Epigallocatechin-3-gallate), micronutrients, including vitamin A,
vitamin D, vitamin K, magnesium and zinc in addition to antioxidants exhibit improvement in
the symptomatic condition of cystic fibrosis patients.

Conclusion:
The advent of nutraceuticals in the food industry and studies indicating their
promising benefits have paved a path for targeted therapies in cystic fibrosis.
Bioactive Molecule-incorporated Polymeric Electrospun Fibers for Bone
Tissue Engineering
Authors: Purushothaman Aarkampoondi Elumalai , Abhinandan Ranganathan , Adithya Senthilkumar Pranav , Sidharthan Dharmaraj Saleth , Balagangadharan Kalimuthu , Selvamurugan Nagarajan 
Published: April 2022

Abstract:
Bone tissue engineering (BTE) is based on the participation and combination of different biomaterials,
cells, and bioactive molecules to generate biosynthetic grafts for bone regeneration. Electrospinning
has been used to fabricate fibrous scaffolds, which provide nanoscale architecture comprising
interconnecting pores, resembling the natural hierarchy of tissues and enabling the formation of artificial
functional tissues. Electrospun fibers for BTE applications have been mostly produced from polymers
(chitosan, alginate, polycaprolactone, polylactic acid) and bioceramics (hydroxyapatite). Stem cells are
among the most prolific cell types employed in regenerative medicine owing to their self-renewal and
differentiation capacity. Most importantly, bioactive molecules, such as synthetic drugs, growth factors,
and phytocompounds, are consistently used to regulate cell behavior inducing differentiation towards the
osteoblast lineage. An expanding body of literature has provided evidence that these electrospun fibers
loaded with bioactive molecules support the differentiation of stem cells towards osteoblasts. Thus, this
review briefly describes the current development of polymers and bioceramic-based electrospun fibers
and the influence of bioactive molecules in these electrospun fibers on bone tissue regeneration.
Is there Cholinesterase Activity in the Eye?
Authors: Durán-Cristiano Sandra Carolina 
Published: April 2022

Abstract:
The nervous system regulates the visual system through neurotransmitters that play an
important role in visual and ocular functions. One of those neurotransmitters is acetylcholine, a
key molecule that plays a variety of biological functions. Moreover, acetylcholinesterase, the enzyme
responsible for the hydrolysis of acetylcholine, is implicated in cholinergic function. However,
several studies have demonstrated that in addition to their enzymatic functions, acetylcholinesterase
exerts non-catalytic functions. In recent years, the importance of evaluating all possible
functions of acetylcholine-acetylcholinesterase has been shown. Nevertheless, there is evidence
suggesting that cholinesterase activity in the eye can regulate some biological events both in structures
of the anterior and posterior segment of the eye and, therefore, in the visual information that
is processed in the visual cortex. Hence, the evaluation of cholinesterase activity could be a possible
marker of alterations in cholinergic activity in both ocular and systemic diseases.
Prediction of Risk of Frailty Among Institutionalized Older Adults in
India
Authors: Nandakumar Girish , Kulal Nisha , Vaishali K  
Published: April 2022

Background:
Frailty is a state of age-related physiological vulnerability resulting from impaired homeostatic reserve and a reduced capacity of the individual to withstand stress and an independent predictor of deleterious health outcomes among the aged. Early identification of people who are at risk for frailty is vital in prevention and minimizing its socio-economic consequences in low-resource countries like India. However, risk factors for frailty among Indian institutionalized older adults have been seldom explored.

Objective:
To develop a prediction model for the risk of frailty among institutionalized older adults

Method:
This study adopted a case-control design, wherein institutionalized adults were categorized into frail and non-frail, using Fried’s criteria. Individuals above 55 years of age, who could follow instructions; without severe motor and cognitive impairment and terminal illness were recruited from nine conveniently selected institutions. Socio-demographic, lifestyle, behavioral, and; physical performance factors were evaluated one hundred participants.

Results:
Among the fourteen independent variables, age, cognition, income, functional mobility, polypharmacy and presence of more than 3 comorbidities were significant in univariate analysis. But adjusted odds ratio showed a statistical significance for low educational status, low income, poor functional mobility, and presence of more than 3 co-morbidities only, hence they were used for developing the prediction model.

Conclusion:
Low education status, low income, poor functional mobility, and presence of more than 3 comorbidities were found to have a significant association with the risk of frailty. A model has been developed to predict the risk and early identification of frailty among institutionalized older adults.
Vitamin C and D Supplements to Prevent the Risk of COVID-19
Authors: Shahrajabian Mohamad Hesam , Sun Wenli , Cheng Qi 
Published: April 2022

Background:
Virus is a tiny agent, around one-hundredth the size of a bacterium which can infect cells of plants and animals. Seven coronaviruses are known to infect humans, three of them are serious, namely, SARS (severe acute respiratory syndrome, China, 2002), MERS (Middle East respiratory syndrome, Saudi Arabia, 2012), and SARS-CoV-2 (COVID-19) (2019-2020).SARS-CoV, and MERS-CoV belong to betacoronaviruses (betaCoVs).

Objective:
In this mini review, we want to consider the important vitamin D and C, especially plants containing these two vitamins in fight against COVID-19.

Methods:
The manuscript includes review articles, randomized control experiments, analytical studies and observations, which have been gathered from different sources such as Google Scholar, Scopus, Science Direct and PubMed. A review of the literature was carried out using the keywords such as vitamin D, vitamin C, COVID-19, influenza, Plant, and Coronaviruses.

Results:
Various sources of vitamin D for humans are food, dietary supplements and the skin by exposure to 7-dehydrocholesterol to ultraviolet light. There are some new findings on influence vitamin D in prevent and control of influenza and COVID-19. Vitamin D may play roles in preventing influenza and covid-19 by production of large quantities of IL-1 and IL-6, or modulating the production of the interleukins.

Conclusion:
Vitamin D deficiency is a potential link between respiratory infection and immune evasion, and vitamin D is a pleiotropic factor known to modulate immune response against pathogen.
Are Histamine H3 Antagonists the Definitive Treatment for Acute Methamphetamine
Intoxication?
Authors: Kitanaka Nobue , Kitanaka, Junichi , Hall F. Scott , Tanaka, Koh-ichi , Tomita Kazuo , Igarashi Kento , Nishiyama Nobuyoshi , Sato Tomoaki , Uhl George R. 
Published: April 2022

Background:
Methamphetamine (METH) is classified as a Schedule II stimulant drug
under the United Nations Convention on Psychotropic Substances of 1971. METH and other amphetamine
analogues (AMPHs) are powerful addictive drugs. Treatments are needed to treat the
symptoms of METH addiction, chronic METH use, and acute METH overdose. No effective
treatment for METH abuse has been established because alterations of brain functions under the
excessive intake of abused drug intake are largely irreversible due in part to brain damage that
occurs in the course of chronic METH use.

Objective:
Modulation of brain histamine neurotransmission is involved in several neuropsychiatric
disorders, including substance use disorders. This review discusses the possible mechanisms
underlying the therapeutic effects of histamine H3 receptor antagonists on symptoms of methamphetamine
abuse.

Conclusion:
Treatment of mice with centrally acting histamine H3 receptor antagonists increases
hypothalamic histamine contents and reduces high-dose METH effects while potentiating lowdose
effects via histamine H1 receptors that bind released histamine. On the basis of experimental
evidence, it is hypothesized that histamine H3 receptors may be an effective target for the treatment
METH use disorder or other adverse effects of chronic METH use.
Factors Influencing Increased Use of Technology to Communicate With Others During the COVID-19 Pandemic: Cross-sectional Web-Based Survey Study
Authors: Dawe-Lane Erin , Mutepua Magano , Morris Daniel , Odoi Clarissa M , Wilson Emma , Evans Joanne , Pinfold Vanessa , Wykes Til , Jilka Sagar , Simblett Sara 
Published: April 2022

Background
Communication via technology is regarded as an effective way of maintaining social connection and helping individuals to cope with the psychological impact of social distancing measures during a pandemic. However, there is little information about which factors have influenced increased use of technology to communicate with others during lockdowns and whether this has changed over time.

Objective
The aim of this study is to explore which psychosocial factors (eg, mental health and employment) and pandemic-related factors (eg, shielding and time) influenced an increase in communication via technology during the first lockdown in the United Kingdom.

Methods
A cross-sectional, web-based survey was conducted between April and July 2020, examining thoughts, feelings, and behaviors associated with the pandemic, including communicating more using technology (eg, via messaging, phone, or video). We collected sociodemographic information, employment status, mental health service user status, and depression symptoms. We used hierarchical logistic regression to test which factors were associated with communicating more using technology during the lockdown.

Results
Participants (N=1464) were on average 41.07 (SD 14.61) years old, and mostly women (n=1141; 77.9%), White (n=1265; 86.4%), and employed (n=1030; 70.4%). Participants reported a mild level of depression (mean 9.43, SD 7.02), and were communicating more using technology (n=1164; 79.5%). The hierarchical regression indicated that people who were employed and experiencing lower levels of depression were more likely to report increased communication using technology during a lockdown period of the COVID-19 pandemic, and over time, men communicated more using technology. Increased use of technology to communicate was related to greater communication and the inability to see others due to the social distancing measures enacted during the lockdown. It was not related to a general increase in technology use during the lockdown.

Conclusions
Although most participants reported increased use of technology to communicate during a lockdown period of the COVID-19 pandemic, this was more apparent in the employed and those experiencing low levels of depression. Moving forward, we should continue to monitor groups who may have been excluded from the benefits of support and communication using technology.
The Impact of Benefit Plan Audits on the Financial Statement Audit
Authors: Prentice Jaclyn D. , Bills Kenneth L. , Peters Gary F. 
Published: April 2022

SYNOPSIS
Benefit plan audits, a material but less understood public accounting service, represent a nonaudit service that is “audit related.” We explore the implications of benefit plan audits for the financial statement audit and find that performing a benefit plan audit for a company significantly increases the likelihood that the firm will be selected as a company’s financial statement auditor in the future, particularly for smaller audit firms. Further, we find that companies that engage the same audit firm for both their benefit plan and financial statement audits have a significantly lower likelihood of misstatements and shorter audit report lags. Finally, we find evidence consistent with the joint provision of these services creating greater bonding and higher switching costs for the financial statement audit. Our findings speak to the continued debate over effective market expansion of financial statement audit providers, audit quality determinants, and audit efficiencies.
JEL Classifications: M4; M40; M41; M42; M49.
PENGARUH LAMA PENYIMPANAN TERHADAP DAYA SUKA SENSORI DAGING BROILER YANG DIBERI EKSTRAK BAWANG PUTIH SEBAGAI PENGAWET
Authors: Dan Dian Septinova Aprinando, Riyanti, 
Published: April 2022

Garlic (Alliumsativum Linn) is one of the herbs that have been shown to inhibit the growth of microorganisms. Component of garlic that has been shown to inhibit microbe is allicin or diallyl acid tiosulfinat. This study aims to determine the effect of storage length on preference test sensory color, aroma, flavor chunks of breast meat of broilers fed extracts of garlic, Determine the effect of storage length to the preference test sensory color, aroma, and flavor chunks of breast meat of broilers fed extracts of garlic. This research was conducted at the Laboratory of Animal Production and Reproduction Department of Animal Husbandry, Faculty of Agriculture, University of Lampung and meat samples obtained from RPA Hi. Nasir, Jl. Skin,Langkapura, Kemiling, Bandar Lampung City. Treatment using a completely randomized design (CRD) with four treatments and twenty replications. The treatments were storage length 0, 3, 6, 9 hoursmeat broiler fed extracts of garlic. The data were analyzed ANOVA(Analysis of Variance) at the 5% significance level.These results indicate that giving garlic extract 10% inmeat storage broiler 0, 3, 6, 9 hours no real effect (P> 0.05) to power the likes sensory (color, aroma, and flavor).
Keywords: meat broiler, garlic, storage length, preference test, sensory.
PENGARUH PENCELUPAN TELUR TETAS ITIK HIBRIDA MENGGUNAKAN EKSTRAK DAUN SALAM SEBAGAI DESINFEKTAN ALAMI TERHADAP DAYA TETAS, MORTALITAS EMBRIO, DAN SALEABLE DUCK
Authors: Gunawan Reynaldy , Nova Khaira , Riyanti RR , Septinova Dian 
Published: April 2022

This study aimed to determine the effect of immersion of hybrid duck eggs using bay leaf extract with different concentrations on embryo mortality, hatchability, and saleable duck and to determine the best concentration in immersing hybrid duck eggs using bay leaf extract on embryo mortality, hatchability, and saleable duck. The research was carried out in May - June 2020, the manufacture of bay leaf extract was carried out at the Animal Production and Reproduction Laboratory, Department of Animal Husbandry, Faculty of Agriculture, University of Lampung, and the hatching process was carried out in Gunung Mas Village, Teluk Betung Selatan District, Bandar Lampung City. This study used a completely randomized design (CRD) with four treatments, namely without dyeing the bay leaf extract (P0), dyeing with bay leaf extract with a concentration of 10% (P1), dyeing with bay leaf extract with a concentration of 20% (P2), dyeing with bay leaf extract. with concentration of 30% (P3). Each treatment was repeated 5 times with each experimental unit amounting to 5 hybrid duck eggs so that 100 eggs were used. The variables observed were embryo mortality, hatchability, and saleable duck. The results showed that immersion of hybrid duck eggs using bay leaf extract at concentrations of 10%, 20%, and 30% had no significant effect on embryo mortality, hatchability, and salable duck of hybrid duck and there was no the best bay leaf solution dosage to reduce embryo mortality, and increase hatchability and saleable duck of hybrid duck.

Keywords : Bay leaf, Embryo mortality, Extract, Hatchability, Hybrid duck, Saleable duck
PENGARUH LAMA PENYIMPANAN TELUR HERBAL AYAM RAS FASE PERTAMA DI REFRIGERATOR TERHADAP PENURUNAN BERAT TELUR, DIAMETER RONGGA UDARA, DAN INDEKS ALBUMEN
Authors: Astuti Diana Widi , Nova Khaira , Sutrisna Rudy , Septinova Dian 
Published: April 2022

This study aimed to: (1) determine the effect of storage time of herbal eggs of chicken first phase in refrigerator temperature on egg weight loss, air cavity diameter, and albumen index, (2) determine the best storage time for herbal eggs of chicken first phase in refrigerator temperature (7,2oC) on egg weight loss, air cavity diameter, and albumen index. This research was conducted on October 7th – November 4th, 2020, at the Animal Production Laboratory, Department of Animal Husbandry, Faculty of Agriculture, University of Lampung. The material used were 60 eggs obtained from Sekuntum Herbal Farm with average weight of 56.67±3.21 g of first phase Lohmann strain chicken (30--40 weeks). The design used was a completely randomized design (CRD) with 5 treatments including storage time for 0, 1, 2, 3, 4 week and 4 replications. The variables observed were egg weight loss, air cavity diameter, and albumen index. The data obtained were analyzed based on Analysis of Variance at 5% significance level. The results that had a significant effect were further tested using the Least Significant Difference (LSD). The results showed that the storage time gave a significant effect (P<0.05) on egg weight loss, air cavity diameter, and albumen index of first phase chicken eggs. The storage time of herbal eggs for 1 week at refrigerator temperature showed better quality based on egg weight loss which was still low (1.14%), air cavity diameter (1.983cm), and albumen index (0.073).
Key words: Herbal eggs, egg weight loss, air cavity, albumen index, refrigerator
TINGKAT INFESTASI CACING HATI PADA KAMBING DI KELOMPOK TERNAK KECAMATAN SUKOHARJO KABUPATEN PRINGSEWU PROVINSI LAMPUNG
Authors: Fatmawati Siti Tika , Siswanto Siswanto , Santosa Purnama Edy , Qisthon Arif , Arfianto Johan 
Published: April 2022

Research on liver worm infestation levels in goats was held on 1--30 March 2021 at three livestock groups of Rukun Amrih Sentosa, Mekar 4, and Sido Makmur in Sukoharjo District, Pringsewu Regency. This research aimed to know the infestation level of liver worms in goats. The research method was a survey method with proportional random sampling. The number of samples was 85 goats from the livestock group in Sukoharjo District. Examination of fecal samples was carried out at the Parasitology Laboratory Lampung Veterinary Center using a sedimentation test. The data obtained were presented in tabulation form and then analyzed descriptively. The results showed that the liver fluke infestation level on goats was found at Rukun Amrih Sentosa at 3.77%, while at Mekar 4 and Sido Makmur, the liver fluke infestation was not found (0%). From the results of the examination of samples in Sukoharjo District, it was known that there were 2 positive samples of Fasciola (2.35%) from 85 samples examined, meaning that the level of liver worm infestation in the livestock group of Sukoharjo District was low.

Keywords: Goat, Infestation level, Liver worms
PENGARUH SENAM AEROBIK TERHADAP KADAR TRIGLISERIDA BERAT BADAN BERLEBIH (OVERWEIGHT) DI UNIMED HEALTHY COMMUNITY (UHC) UNIMED
Authors: Simanjuntak Sahata , Hasibuan Rosmaini 
Published: April 2022

Tujuan penelitian ini untuk menemukan informasi tentang pengaruh senam aerobik terhadap kadar trigliserida berat badan berlebih (Overweight) di Unimed Healthy Community (UHC) UNIMED. Penelitian ini dilakukan di stadion Universitas Negeri Medan dan Dinas Kesehatan Provinsi Sumatera Utara UPT Laboratorium Kesehatan Daerah, Kota MedanPenelitian ini menggunakan metode eksperimen dengan rancangan desain penelitian One Group Pre-Test Post-Test Design.Populasi dalam penelitian ini terdiri dari 30 orang. Jumlah sampel yang sebanyak 13 orang yang ditetapkan dengan menggunakan teknik purposive sampling. Selama 8 minggu dengan dosis FITT: a) frekuensi 3 kali seminggu, b) intensitas berat: 70-80 % DNM, c) tipe hight impact, d) time 45 menit. Pemeriksaan kadar trigliserida dilakukan di awal dan diakhir perlakuan. Data dianalisis mengunakan uji-t statistic. Hasil data yang di peroleh dimana nilai signifikan ɑ=0,05 dengan taraf kepercayaan 95% dan dibandingkan dengan hasil yang didapat dimana thitung> ttabel atau 4,096> 1,77Berdasarkan hasil pengujian hipotesis dan pembahasan penelitian dimana Hipotesis statistik Ha: thitung> ttabel dan Ho: thitung<ttabel. Maka dapat menyimpulkan bahwa adanya pengaruh senam aerobik terhadap kadar trigliserida berat badan berlebih (overweight) di Unimed Healthy Community (UHC) UNIMED.