bluuebunny/crossref_metadata_2025_split huggingface dataset:
TCOF1 is a single-component scaffold of the nucleolar fibrillar center
Authors: Jaberi-Lashkari Nima , Lee Byron , Aryan Fardin , Calo Eliezer 
Published: October 2022

AbstractMany of the biological structures that exist across the tree of life are built on self-interacting scaffolds, from the actin cytoskeleton to the collagen extracellular matrix. Intracellular membraneless organelles, such as the nucleolus, are biological structures consisting of hundreds of dynamically interacting components, yet it is unclear whether the underlying organization of these complex assemblies can be scaffolded by such self-interacting components. Here, we show that TCOF1 is a single-component scaffold of the nucleolar fibrillar center (FC), based on thermodynamics of its assembly in cells, as well as sufficiency and loss-of-function experiments. TCOF1 is necessary for the formation of the FC, and defines the FC through assembly mediated by homotypic interactions of its Serine/Glutamate (S/E)-rich low-complexity regions (LCRs). Ultimately, introduction of TCOF1 into a species that lacks the FC is sufficient to form an FC-like nucleolar subcompartment. Thus, we demonstrate how a single protein component can explain the formation and evolution of a complex biological structure.
Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy
Authors: Jiang Yufei , He Yan , Liu Songting , Li Gaizhen , Chen Dunjin , Deng Wenbo , Li Ping , Zhang Ying , Wu Jinxiang , Li Jianing , Wang Longmei , Lin Jiajing , Wang Haibin , Kong Shuangbo , Shi Guixiu 
Published: October 2022

AbstractDecidualization, denoting the transformation of endometrial stromal cells into specialized decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy in human. Here we demonstrated that knockout of Gaq lead to an aberrantly enhanced inflammatory state during decidualization. Furthermore, we showed that deficiency of Gaq resulted in over-activation of nuclear factor (NF)-κB signaling, due to the decreased expression ofNFκBIA,which encode the IκB protein and is the negative regulator for NFκB. Mechanistically, Gaq deficiency decreased the PKD/PKCμ phosphorylation levels, so leading to attenuated HDAC5 phosphorylation and thus its nuclear export. Aberrantly high level of nuclear HADC5 retarded histone acetylation to inhibitNFκBIAtranscription during decidualization. Consistently, pharmacological activation of the PKD/PKCμ or inhibition of the HDAC5 signaling restored the inflammatory state and proper decidual response. Finally, we disclosed that over-active inflammatory state in Gaq deficient decidua deferred the blastocyst hatching and adhesion in vitro, and the decidual expression of Gαq was significantly lower in women with recurrent pregnancy loss compared with normal pregnancy. In brief, we showed here that Gαq as a key regulator of the inflammatory cytokine’s expression and decidual homeostasis in response to differentiation cues, which is required for successful implantation and early pregnancy.
Is any open innovation pattern emerging in the Italian fashion field? Preliminary evidence from some case studies
Authors: Bigliardi Barbara , Bottani Eleonora , Filippelli Serena , Tagliente Leonardo , Venturini Karen 
Published: October 2022

PurposeThe aim of this paper is to explore whether open innovation is emerging in the Italian fashion industry.Design/methodology/approachBased on available studies on innovation and open innovation, we first identified the main facets of open innovation within the industry investigated, such as the process of searching for new ideas, the involvement of external partners in the new product development process and the use of collaboration mechanisms between supply chain partners. Starting from these findings, the authors designed a semi-structured questionnaire that was used as a guideline for 15 case studies, carried out in the Italian fashion industry.FindingsThe outcomes from the case studies allow drawing some conclusions about the emergency of open innovation in the fashion industry and the related patterns.Originality/valueGiven its exploratory nature, this study is expected to start a debate about open innovation in the fashion industry, as well as to encourage future studies in this field.
Consumption of marketer-generated content: consumers as curators of marketing messages that they consume on social media
Authors: Noguti Valeria 
Published: October 2022

Purpose
This paper aims to understand how structural characteristics of social media enable consumers to satisfy needs related to marketer-generated content (MGC) and identify the consequences of consumer exposure to MGC.

Design/methodology/approach
This paper revisits research on antecedents and consequences of advertising consumption to build an emergent conceptual model applied to MGC through the investigation of consumer experiences in social media. Thirty-three semi-structured interviews were conducted with consumers who follow brands on Instagram. The interview transcripts were coded and analysed using a grounded theory approach.

Findings
This study finds that, structurally, MGC consumption is characterised by the combination of: consumer micro-control over both content and timing/place of consumption and ease of consumption, enabling consumers to seek pleasure and utility without effort. The data show that MGC is only likely to be shared to a restricted group with strong social connections, such as family members and close friends with similar interests, with whom new interactions develop over brands and products, online or in person. MGC consumption experiences also generate significant consumer learning that improves purchase outcomes for consumers. Three types of MGC consumers were identified in the data: “enthusiasts”, “circumstantial” and “occasional”.

Research limitations/implications
This study updates previous literature, offering a conceptual framework that specifies how the structural characteristics of social media are conducive to consumer exposure to self-curated MGC flows. This research also uncovers unique social dynamics and consumer learning related to MGC consumption.

Practical implications
Insights from this study suggest alternative business models that may be attractive for consumers, brands and social media platforms. This research also suggests ways in which brands can improve consumer MGC experiences.

Originality/value
This research demonstrates how and why consumers embrace MGC at scale through social media and reveals consequences of MGC consumption.
Digitization of fabric comfort: a multidimensional evaluation strategy to human perceptions of sensorial, thermal and acoustic comfort in clothing
Authors: Hu Xiaorui , Chen Zihan , Sun Fengxin 
Published: October 2022

PurposeCurrent measurement methods for fabric comfort attributes generally suffer from either complicated testing processes and intricate measuring equipment or partial evaluation objectives and thus are difficult for effectively evaluating multidimensional human perceptions towards the comprehensive comfort of fabrics. The purpose of this paper is to develop a facile test device, namely fabric comfort tester, to achieve a comprehensive evaluation of human sensations in terms of sensorial, thermal and acoustic comfort in clothing.Design/methodology/approachThe prototype of the designed device was introduced, which enables a simultaneous test for multiple physical and mechanical properties of fabrics based on a force sensor and a set of infrared sensors via constructing multi-deformation states of the measured fabrics. Eleven measurement indices extracted from the measurement curves are defined and interpreted based on correlation analysis. A series of regression models are developed by relating the measurement indices with subjective evaluation results and validated by a set of independent samples.FindingsHuman perceptions of sensorial, thermal and acoustic comfort in clothing can be predicted by the measured physical indices and the designed test device with the developed regression models provides an alternative method to characterize the fabric comfort attributes effectively.Originality/valueThe work develops a novel device for objective evaluation of fabric comfort properties by a simultaneous test, integrating the mechanical measurement with thermal test and thereby filling the gap between the existing evaluation methods and practical requirements for the digitalization of fabric comfort in present textile and garment trade.
Citizenship behavior and new venture survival: a cultural tightness-looseness capabilities lens
Authors: Pidduck Robert J. , Kelemen Thomas K. , Bolino Mark C. 
Published: October 2022

PurposeThe authors advance a model theorizing how new ventures elicit citizenship behaviors to cultivate dynamic capabilities that help bolster survival in their nascent years of operations—a characteristically resource-scarce and turbulent context.Design/methodology/approachDrawing on and integrating research on citizenship behaviors with dynamic capabilities, the authors develop a theory that new ventures that are better able to evoke a combination of affiliative and challenging citizenship behaviors from their wider entrepreneurial team (i.e. internal, and external stakeholders) are more adept at mitigating the liabilities of smallness and newness. As these behaviors are spontaneous and not explicitly remunerated, new ventures become stronger at utilizing their limited resource base for remaining lean and agile. Further, key boundary conditions are theorized that the sociocultural norms the venture is embedded within serve to heighten/attenuate the degree to which entrepreneurs can effectively cultivate dynamic capabilities from their team's “extra mile” behaviors.FindingsThe propositions extend a rich body of research on citizenship behaviors into the new venture domain. As all new ventures face the challenge of overcoming liabilities of newness, models that help understand why some are more adept at overcoming this and why others fail, hold substantive practical utility.Originality/valueThis research is the first to unpack how citizenship behaviors manifest among an extended range of stakeholders traditionally overlooked in new venture teams research and the mechanism for how this links to venture survival.
COVID-19, firm characteristics and stock volatility: new evidence from the Indian tourism sector
Authors: Khanna Rupika , Sharma Chandan , Pant Abhay 
Published: October 2022

PurposeThis paper provides new evidence on Indian tourism firms by investigating the role of a firm's financial conditions typified by its leverage, earnings, size, cash holdings, and excess cash in moderating the pandemic-led idiosyncratic volatility in its stock prices.Design/methodology/approachThe authors employ a firm-level panel comprising 82 publicly-listed tourism firms from India. Firm risk is estimated for the period beginning January 2020 to December 2020.FindingsThis paper finds non-linear effects of the pandemic on the idiosyncratic risk of the sample firms. Precisely, stock price volatility rises, but as the market absorbs this information, volatility subsides even as the disease spreads further. Further, lower levels of past debt and earnings and higher cash holdings ameliorate the pandemic's effects on tourism firms' risk. Contrasting the view that “excess” cash reflects poor operational performance, we show that “excess” cash firms are better prepared to face the adverse effects of the pandemic.Research limitations/implicationsThis study’s sample period fully encompasses the first wave of the pandemic (January–December 2020) of the novel coronavirus infection spread.Originality/valueTo the best of the authors’ knowledge, this is the first study to assess the moderating effects of company fundamentals on the risk of Indian tourism firms. In doing so, the authors account for non-linear effects of the pandemic on firms' idiosyncratic volatility over time.
The development of the ERICSO – a proposed instrument for internet child abuse material offender assessment
Authors: Garrington Catherine , Kelty Sally Fiona , Rickwood Debra , Boer Douglas 
Published: October 2022

Purpose
There are a limited number of risk assessment tools relevant to the internet child abuse material (I/CAM) offender cohort. The purpose of this paper is to introduce a new tool, the “Estimated Risk for Internet Child Sexual Offending” (ERICSO). The ERICSO has been developed to assist in the treatment and prevention of sexual crimes against children.

Design/methodology/approach
The ERICSO was developed through a multi-stage process including systematic review, survey of professionals and offender case study.

Findings
An empirically guided tool for estimating risk for I/CAM offenders, the ERICSO is composed of four domains. The Demographic domain questions provide information about the offender, while Collection domain questions address the content of the offender’s files. The Nature of Engagement domain considers the offender’s interaction with I/CAM, behavioural aspects and contact with children. The Social Aspect domain questions address the offender’s engagement with other I/CAM users. Finally, the assessor may use Structured Professional Judgement to provide additional information, and a summary of the offender’s relevant circumstances and a risk estimation.

Practical implications
The ERICSO provides guidance for the assessment of I/CAM offenders who may reoffend with online child sexual offences, and I/CAM offenders who may reoffend with contact child sexual offences.

Originality/value
Born from a history of generational attitudes towards rehabilitation and risk assessment, the launch of the ERICSO presents an exciting opportunity in the risk estimation of I/CAM offenders.
Predominance of Methanomicrobiales and diverse hydrocarbon‐degrading taxa in the Appalachian coalbed biosphere revealed through metagenomics and genome‐resolved metabolisms
Authors: Ross Daniel E. , Lipus Daniel , Gulliver Djuna 
Published: October 2022

AbstractCoalbed deposits are a unique subsurface environment and represent an underutilized resource for methane generation. Microbial communities extant in coalbed deposits are responsible for key subsurface biogeochemical cycling and could be utilized to enhance methane production in areas where existing gas wells have depleted methane stores, or in coalbeds that are unmined, or conversely be utilized for mitigation of methane release. Here we utilize metagenomics and metagenome‐assembled genomes (MAGs) to identify extant microbial lineages and genome‐resolved microbial metabolisms of coalbed produced water, which has not yet been explored in the Appalachian Basin (AppB). Our analyses resulted in the recovery of over 40 MAGs from 8 coalbed methane wells. The most commonly identified taxa among samples were hydrogenotrophic methanogens from the order Methanomicrobiales and these dominant MAGs were highly similar to one another. Conversely, low‐abundance coalbed bacterial populations were taxonomically and functionally diverse, mostly belonging to a variety of Proteobacteria classes, and encoding various hydrocarbon solubilization and degradation pathways. The data presented herein provides novel insights into AppB coalbed microbial ecology, and our findings provide new perspectives on underrepresented Methanocalculus species and low‐relative abundance bacterial assemblages in coalbed environments, and their potential roles in stimulation or mitigation of methane release.
Politicisation of the public service during democratic backsliding: Alternative perspectives
Authors: Peters B. Guy , Pierre Jon 
Published: October 2022

AbstractThis Research Note explores the issue of politicisation of the public service against the backdrop of the emergence of populism. A common feature of populist governments is a lack of trust in the civil service and its willingness to implement the populist political project. An important consequence of marginalising the civil service and its expertise in policy making is detrimental to policymaking. Also, increasing politicisation, that is replacing career public servants with people loyal to the populist regime, drains the public service of organisational memory on how to deal with policy issues. However, liberal democracies in many countries, too, have experienced increasing politicisation over the past decade, albeit within the confines of liberal democratic rules and norms. This emerging, more politicised model of the civil service assumes that neutrality can be an impediment to effective governance and that public servants should be committed to the program of the government. The civil service would be expected to support the government of the day actively and energetically, and therefore there would be fewer barriers. Thus, while politicisation in different forms is a feature of both liberal and populist government, the consequences of politicisation are different in the two regimes.Points for practitioners
In liberal democracies, the civil service offers expertise to support politicians in the policy‐making process. Populist governments, emphasizing loyalty to the regime more than expertise, tend to increase the number of political appointees in the public service.
Most of the populist leaders elected are political outsiders and do not want to be constrained by what they consider to be entrenched and self‐serving elites.
The most pressing dangers for liberal democracy are when populist governments consider policies that would change political and social rights.
Liberal democratic government, too, have increased political control of the public service although without altering the rules and norms of democratic governance.
Age‐related alterations in the nutritional quality of Arctic grayling (Thymallus arcticus)
Authors: Ma Kai , Tong Guangxiang , Zhao Cheng , Yin Jiasheng , Wang Yumei , Zhang Yongquan 
Published: October 2022

AbstractThe biochemical composition of the muscle in Arctic graylings at three age stages was evaluated and compared. For conventional biochemical composition, there was no significant difference in the crude protein content among the three age stages, but the crude fat content in the 1 year old was significantly lower than that of the others (P < 0.05). For amino acids composition, there was no significant difference in the content of essential amino acids and delicious amino acids among the three age stages, but the essential amino acid index of the 2 year old was the highest (72.205), indicating that its essential amino acid composition was more suitable for human needs. For fatty acids composition, the content of monounsaturated fatty acids (2.759 mg/g) and polyunsaturated fatty acids (3.422 mg/g) of the 3 year old was significantly higher than that of the others (P < 0.05), and it also had relatively lowest atherogenicity index (0.419) and thrombogenicity index (0.179) and the highest hypocholesterolemic/hypercholesterolemic fatty acid ratio (2.404), indicating that its fatty acid composition was healthier and more beneficial to the prevention of human cardiovascular and cerebrovascular diseases. For minerals composition, the contents of iron, zinc, and copper increased with age, while the contents of selenium and manganese decreased with age, with the highest selenium content in the 1 year old (1.522 mg/kg). The chromium, arsenic, lead, and cadmium contents were all lower than the Chinese national standard. In conclusion, the nutritional composition of Arctic graylings variated with age and consumers could select suitable Arctic graylings based on their nutritional needs.Practical ApplicationThis work analyzed the nutritional components in the muscle of Arctic graylings at different ages, which can provide an effective reference for consumers when purchasing Arctic graylings.
ERBB2 exon 20 insertions are rare in Brazilian non‐small cell lung cancer
Authors: de Oliveira Cavagna Rodrigo , Zaniolo Beatriz Garbe , de Paula Flávia Escremim , Berardinelli Gustavo Noriz , Santana Iara , da Silva Eduardo Caetano Albino , Dias Josiane Mourão , Jacinto Alexandre Arthur , da Nóbrega Oliveira Rachid Eduardo Noleto , de Marchi Pedro , Leal Letícia Ferro , Reis Rui Manuel 
Published: October 2022

AbstractERBB2 exon 20 insertions may impact the clinical management of lung cancer patients. However, the frequency of ERBB2 exon 20 insertions in lung cancer patients in Brazil is scarce. Here, we analyzed 722 Brazilian non‐small cell lung cancer (NSCLC) patients from Barretos Cancer Hospital that were indicated to require routine lung cancer molecular testing. ERBB2 exon 20 insertions were evaluated by a targeted panel using next‐generation sequencing (NGS). Clinicopathological and molecular data were collected from patient medical records. Among the 722 NSCLC patients, 85.2% had lung adenocarcinomas, 53.9% were male, 66.8% were quitter or current smokers, and 63.2% were diagnosed at an advanced stage of the disease. We identified 0.8% (6/722) of patients who harbored the insertion p.(Tyr772_Ala775dup) at exon 20 of the ERBB2 gene. All ERBB2 mutated patients were diagnosed with lung adenocarcinoma, were never smokers, and wild‐type for EGFR, KRAS, and ALK hotspot alterations. Less than 1% of Brazilian NSCLC patients harbor ERBB2 exon 20 insertions, yet they could benefit in future from the new drugs in development.
Political Uncertainty and Corporate Social Responsibility in a Transition Economy
Authors: Cheng Maoyong , Dong Yuxuan , Jin Justin Y. , Kanagaretnam Kiridaran 
Published: October 2022

AbstractWe examine the influence of political uncertainty on the corporate social responsibility (CSR) of local firms in China. Political uncertainty refers to government officials' turnover. We find that these firms significantly increase their CSR activities when city government officials are changed or replaced. We also find that political uncertainty increases firms' attention to employee responsibilities, supply chain responsibilities, and environmental responsibilities. In addition, the turnover of government officials increases CSR activities due to the reduction or loss of political connections. The anti‐corruption campaign has also strengthened the influence of political uncertainty on CSR.
Effects of electroacupuncture on dry eye: A pilot randomized controlled trial
Authors: Yang Guang , Kong Xiehe , Guo Xiaocong , Yang Yanting , Xie Chen , Lu Yunqiong , Liu Jie , Wu Huangan , Zhang Dan , Zou Yuelan , Zhang Cuihong , Hong Jue , Ma Xiaopeng 
Published: October 2022

AbstractPurposeThe purpose of the study was to assess the efficacy of electroacupuncture on dry eye (DE).MethodsEighty‐four DE patients were randomly assigned to receive electroacupuncture (EAG) three times a week or 0.1% sodium hyaluronate artificial tears (ATG) four times per day for 4 weeks. The primary outcomes were non‐invasive tear film breakup time (NIBUT) and tear meniscus height (TMH). The secondary outcomes included the ocular surface disease index (OSDI), Schirmer I test (SIT), corneal sodium fluorescein staining (CFS) score, corneal topography descriptors surface asymmetry index (SAI) and surface regularity index (SRI), corneal sensitivity, 36‐item Short‐form Health Survey (SF‐36) score and Hospital Anxiety and Depression Scale (HADS) score. All outcomes were assessed at Week 0 (baseline), Week 4 (after‐treatment) and Week 8 (follow‐up).ResultsBetween‐group comparisons showed significant differences in the changes in NIBUT (Week 4, p = 0.003; Week 8, p = 0.008), TMH (Week 4, p = 0.014; Week 8, p = 0.009), OSDI (Week 4, p = 0.029; Week 8, p = 0.022), CFS score (Week 8, p = 0.036) and SF‐36 role‐physical score (Week 4, p = 0.010), favouring EAG. Mean changes in SIT, SAI, SRI, corneal sensitivity and HADS scores were statistically equal between the two groups (all p > 0.05). Treatment with electroacupuncture was well‐tolerated and showed minimal adverse events.ConclusionsCompared with artificial tears, electroacupuncture shows superior efficacy in improving tear film stability and symptoms of DE.