bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosimetric and feasibility evaluation of a CBCT‐based daily adaptive radiotherapy protocol for locally advanced cervical cancer
Authors: Branco Daniela , Mayadev Jyoti , Moore Kevin , Ray Xenia 
Published: October 2022

AbstractPurposeEvaluate a cone‐beam computed tomography (CBCT)‐based daily adaptive platform in cervical cancer for multiple endpoints: (1) physics contouring accuracy of daily CTVs, (2) CTV coverage with adapted plans and reduced PTV margins versus non‐adapted plans with standard‐of‐care (SOC) margins, (3) dosimetric improvements to CTV and organs‐at‐risk (OARs), and (4) on‐couch time.Methods and materialsUsing a Varian Ethos™ emulator and KV‐CBCT scans, we simulated the doses 15 retrospective cervical cancer patients would have received with/without online adaptation for five fractions. We compared contours and doses from SOC plans (5–15 mm CTV‐to‐PTV margins) to adapted plans (3 mm margins). Auto‐segmented CTVs and OARs were reviewed and edited by trained physicists. Physics‐edited targets were evaluated by an oncologist. Time spent reviewing and editing auto‐segmented structures was recorded. Metrics from the CTV (D99%), bowel (V45Gy, V40Gy), bladder (D50%), and rectum (D50%) were compared.ResultsThe physician approved the physics‐edited CTVs for 55/75 fractions; 16/75 required reductions, and 4/75 required CTV expansions. CTVs were encapsulated by unadapted, SOC PTVs for 56/75 (72%) fractions—representative of current clinical practice. CTVs were completely covered by adapted 3 mm PTVs for 71/75 (94.6%) fractions. CTV D99% values for adapted plans were comparable to non‐adapted SOC plans (average difference of −0.9%), while all OAR metrics improved with adaptation. Specifically, bowel V45Gy and V40Gy decreased on average by 87.6 and 109.4 cc, while bladder and rectum D50% decreased by 37.7% and 35.8%, respectively. The time required for contouring and calculating an adaptive plan for 65/75 fractions was less than 20 min (range: 1–29 min).ConclusionsImproved dose metrics with daily adaption could translate to reduced toxicity while maintaining tumor control. Training physicists to perform contouring edits could minimize the time physicians are required at adaptive sessions improving clinical efficiency. All emulated adaptive sessions were completed within 30 min however extra time will be required for patient setup, image acquisition, and treatment delivery.
COMP Report: CPQR technical quality control guidelines for use of positron emission tomography/computed tomography in radiation treatment planning
Authors: Klein Ran , Oliver Mike , La Russa Dan , Agapito John , Gaede Stewart , Bissonnette JeanPierre , Rahmim Arman , Uribe Carlos 
Published: October 2022

AbstractPositron emission tomography with x‐ray computed tomography (PET/CT) is increasingly being utilized for radiation treatment planning (RTP). Accurate delivery of RT therefore depends on quality PET/CT data. This study covers quality control (QC) procedures required for PET/CT for diagnostic imaging and incremental QC required for RTP. Based on a review of the literature, it compiles a list of recommended tests, performance frequencies, and tolerances, as well as references to documents detailing how to perform each test. The report was commissioned by the Canadian Organization of Medical Physicists as part of the Canadian Partnership for Quality Radiotherapy initiative.
Cell‐Derived Vesicles with Increased Stability and On‐Demand Functionality by Equipping Their Membrane with a Cross‐Linkable Copolymer
Authors: Huang Xinan , Hürlimann Dimitri , Spanke Hendrik T. , Wu Dalin , Skowicki Michal , Dinu Ionel Adrian , Dufresne Eric R. , Palivan Cornelia G. 
Published: October 2022

AbstractCell‐derived vesicles retain the cytoplasm and much of the native cell membrane composition. Therefore, they are attractive for investigations of membrane biophysics, drug delivery systems, and complex molecular factories. However, their fragility and aggregation limit their applications. Here, the mechanical properties and stability of giant plasma membrane vesicles (GPMVs) are enhanced by decorating them with a specifically designed diblock copolymer, cholesteryl‐poly[2‐aminoethyl methacrylate‐b‐poly(ethylene glycol) methyl ether acrylate]. When cross‐linked, this polymer brush enhances the stability of the GPMVs. Furthermore, the pH‐responsiveness of the copolymer layer allows for a controlled cargo loading/release, which may enable various bioapplications. Importantly, the cross‐linked‐copolymer GPMVs are not cytotoxic and preserve in vitro membrane integrity and functionality. This effective strategy to equip the cell‐derived vesicles with stimuli‐responsive cross‐linkable copolymers is expected to open a new route to the stabilization of natural membrane systems and overcome barriers to biomedical applications.
Tolerogenic Nanovaccine for Prevention and Treatment of Autoimmune Encephalomyelitis
Authors: Park Jinwon , Le Quoc‐Viet , Wu Yina , Lee Jaiwoo , Oh Yu‐Kyoung 
Published: October 2022

AbstractHerein, a tolerogenic nanovaccine is developed and tested on an animal model of multiple sclerosis. The nanovaccine is constructed to deliver the self‐antigen, myelin oligodendrocyte glycoprotein (MOG) peptide, and dexamethasone on an abatacept‐modified polydopamine core nanoparticle (AbaLDPN‐MOG). AbaLDPN‐MOG can target dendritic cells and undergo endocytosis followed by trafficking to lysosomes. AbaLDPN‐MOG blocks the interaction between CD80/CD86 and CD28 in antigen‐presenting cells and T cells, leading to decreased interferon gamma secretion. The subcutaneous administration of AbaLDPN‐MOG to mice yields significant biodistribution to lymph nodes and, in experimental‐autoimmune encephalomyelitis (EAE) model mice, increases the integrity of the myelin basic sheath and minimizes the infiltration of immune cells. EAE mice are treated with AbaLDPN‐MOG before or after injection of the autoantigen, MOG. Preimmunization of AbaLDPN‐MOG before the injection of MOG completely blocks the development of clinical symptoms. Early treatment with AbaLDPN‐MOG at three days after injection of MOG also completely blocks the development of symptoms. Notably, treatment of EAE symptom‐developed mice with AbaLDPN‐MOG significantly alleviates the symptoms, indicating that the nanovaccine has therapeutic effects. Although AbaLDPN is used for MOG peptide delivery in the EAE model, the concept of AbaLDPN can be widely applied for the prevention and alleviation of other autoimmune diseases.
Coexistence of Urbach‐Tail‐Like Localized States and Metallic Conduction Channels in Nitrogen‐Doped 3D Curved Graphene
Authors: Tanabe Yoichi , Ito Yoshikazu , Sugawara Katsuaki , Jeong Samuel , Ohto Tatsuhiko , Nishiuchi Tomohiko , Kawada Naoaki , Kimura Shojiro , Aleman Christopher Florencio , Takahashi Takashi , Kotani Motoko , Chen Mingwei 
Published: October 2022

AbstractNitrogen (N) doping is one of the most effective approaches to tailor the chemical and physical properties of graphene. By the interplay between N dopants and 3D curvature of graphene lattices, N‐doped 3D graphene displays superior performance in electrocatalysis and solar‐energy harvesting for energy and environmental applications. However, the electrical transport properties and the electronic states, which are the key factors to understand the origins of the N‐doping effect in 3D graphene, are still missing. The electronic properties of N‐doped 3D graphene are systematically investigated by an electric‐double‐layer transistor method. It is demonstrated that Urbach‐tail‐like localized states are located around the neutral point of N‐doped 3D graphene with the background metallic transport channels. The dual nature of electronic states, generated by the synergistic effect of N dopants and 3D curvature of graphene, can be the electronic origin of the high electrocatalysis, enhanced molecular adsorption, and light absorption of N‐doped 3D graphene.
Stable Tetradentate Gold(III)‐TADF Emitters with Close to Unity Quantum Yield and Radiative Decay Rate Constant of up to 2 × 106s−1: High‐Efficiency Green OLEDs with Operational Lifetime (LT90) Longer than 1800 h at 1000 cd m−2
Authors: Zhou Dongling , Tong Glenna So Ming , Cheng Gang , Tang Yu‐Kan , Liu Wei , Ma Dongge , Du Lili , Chen Jian‐Rui , Che Chi‐Ming 
Published: October 2022

AbstractHigh maximum external quantum efficiency (EQEmax), small efficiency roll‐offs, and long operational lifetime at practical luminances are three crucial parameters for commercialization of organic light‐emitting diodes (OLEDs). To simultaneously achieve these goals, it is desirable to have the radiative decay rate constant (kr) as large as possible, which, for a thermally activated delayed fluorescent (TADF) emitter, requires both a large S1→S0radiative decay rate constant (krS) and a small singlet–triplet energy gap (ΔEST). Here, the design of a class of tetradentate gold(III) TADF complexes for narrowing the ΔESTwhile keeping thekrSlarge is reported. The as‐synthesized complexes display green emission with close to unity emission quantum yields, andkrapproaching 2 × 106s−1in thin films. The vacuum‐deposited green OLEDs based on1and4demonstrate maximum EQEs of up to 24 and 27% with efficiency roll‐offs of 5.5 and 2.2% at 1000 cd m−2, respectively; the EQEs maintain high at 10 000 cd m−2(19% (1) and 24% (4)). A long LT90device lifetime of 1820 h at 1000 cd m−2for complex1is achieved, which is one of the longest device lifetimes of TADF‐OLEDs reported in the literature.
Probing Temperature‐Induced Phase Transitions at Individual Ferroelectric Domain Walls
Authors: Kelley Kyle P. , Kalinin Sergei V. , Eliseev Eugene , Raghuraman Shivaranjan , Jesse Stephen , Maksymovych Peter , Morozovska Anna N. 
Published: October 2022

AbstractFerroelectric domain walls have emerged as one of the most fascinating objects in condensed matter physics due to the broad variability of functional behaviors they exhibit. However, the vast majority of domain walls studies have been focused on bias‐induced dynamics and transport behaviors. Here, the scanning probe microscopy approach based on piezoresponse force microscopy (PFM) with a dynamically heated probe, combining local heating and local biasing of the material is introduced. This approach is used to explore the thermal polarization dynamics in soft Sn2P2S6 ferroelectrics, and allows for the exploration of phase transitions at individual domain walls. The strong and weak modulation regimes for the thermal PFM are introduced. The future potential applications of heated probe approach for functional SPM measurements including piezoelectric, elastic, microwave, and transport measurements are discussed.
Evaluation of the Passivation Effects of PEDOT:PSS on Inverted Perovskite Solar Cells
Authors: Qi Yifang , Almtiri Mohammed , Giri Hari , Jha Surabhi , Ma Guorong , Shaik Abdul Kalam , Zhang Qiqi , Pradhan Nihar , Gu Xiaodan , Hammer Nathan I. , Patton Derek , Scott Colleen , Dai Qilin 
Published: October 2022

AbstractPoly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is a popular hole transport material in perovskite solar cells (PSCs). However, the devices with PEDOT:PSS exhibit large open‐circuit voltage (Voc) loss and low efficiency, which is attributed to mismatched energy level alignment and the poor interface of PEDOT:PSS and perovskite. Here, three polymer analogues to polyaniline (PANI), PANI–carbazole (P1), PANI–phenoxazine (P2), and PANI–phenothiazine (P3) are designed with different energy levels to modify the interface between PEDOT:PSS and the perovskite layer and improve the device performance. The effects of the polymers on the device performance are demonstrated by evaluating the work function adjustment, perovskite growth control, and interface modification in MAPbI3‐based PSCs. Low bandgap Sn–Pb‐based PSCs are also fabricated to confirm the effects of the polymers. Three effects are evaluated through the comparison study of PEDOT:PSS‐based organic solar cells and MAPbI3 PSCs based on the PEDOT:PSS modified by P1, P2, and P3. The order of contribution for the three effects is work function adjustment > surface modification > perovskite growth control. MAPbI3 PSCs modified with P2 exhibit a high Voc of 1.13 V and a high‐power conversion efficiency of 21.06%. This work provides the fundamental understanding of the interface passivation effects for PEDOT:PSS‐based optoelectronic devices.
Usual nutrient intake and dietary quality of low‐income U.S. older adults
Authors: Qin Yue , Cowan Alexandra E. , Bailey Regan L. , Jun Shinyoung , Eicher‐Miller Heather A. 
Published: October 2022

AbstractWe estimate nutrient intake from diet and total sources including dietary supplements (DS), and dietary quality of low‐income U.S. older adults (60+ years) using the 2007–2016 National Health and Nutrition Examination Survey. We apply the National Cancer Institute method to determine usual/habitual nutrient intake distributions. Our results reveal that low‐income older adults have poor nutrient intake and dietary quality. DS use reduces the risk of nutrient inadequacy but is not associated with statistically significantly better dietary quality. Future policies that would change access to nutrients through DS should consider the current DS contributions to nutrient intake among the low‐income, older population.
Air quality monitoring of sow houses with the fuzzy comprehensive evaluation method
Authors: Chen Chong , Shen Cuifeng , Duan Wenyong 
Published: October 2022

AbstractThe comfort of sow house environments is dependent on several aspects. Therefore, it is difficult to accurately assess and control the environment by applying a single factor. In this study, Shannon's entropy theory, the fuzzy comprehensive evaluation (FCE) method, as well as the improved analytic hierarchy process (IAHP) were combined to provide reasonable subjective and objective weights for environmental comfort evaluation modeling. In addition, an evaluation index system including five environmental factors was established. To decide the membership degree of each environmental factor, we proposed a method to establish fuzzy membership functions (MFs) and devised a calculation method for related parameters. Three basic types of MFs, including the trapezoidal membership function (trapmf), pi‐shaped membership function (pimf), and ridge membership function (ridgemf), were adopted to establish an evaluation model that fit well with the entropy‐IAHP‐FCE model. The proposed method was verified using real measurements of spatiotemporal data, and results show that multiple environmental parameters were successfully integrated into the FCE for sow house environment evaluation. The FCE method delivered higher correlation coefficients of 0.8785, 0.9512, and 0.9719 compared with the temperature‐humidity index, single‐factor evaluation, and least squares support vector regression methods. The FCE method enhances sensitivity and performs an effective evaluation of environmental comfort. It can be integrated into environmental control and early‐warning systems for environmental management optimization, thereby enhancing sow production and welfare.
Experimental determination of dissociation constants (pKa) for N‐(2‐aminoethyl)‐1,3‐propanediamine, 2‐methylpentamethylene diamine, N,N‐dimethyldipropylenetriamine, 3,3′‐diamino‐N‐methyldipropyl‐amine, Bis[2‐(N,N‐dimethylamino)ethyl]ether, 2‐[2‐(dimethyl‐amino) ethoxy] ethanol, 2‐(dibutylamino) ethanol, and N‐propylethanol‐amine and modeling with artificial neural network
Authors: Liu Gao , Nguyen William (Hoang Chi Hieu) , Henni Amr 
Published: October 2022

AbstractThe dissociation constants (pKa) of the eight amines, namely, N‐(2‐aminoethyl)‐1,3‐propanediamine, 2‐methylpentamethylene diamine, N,N‐dimethyldipropylene‐triamine, 3,3′‐diamino‐N‐methyl‐dipropylamine, Bis[2‐(N,N‐dimethylamino) ethyl]ether, 2‐[2‐(dimethyl‐amino)ethoxy] ethanol, 2‐(dibutylamino) ethanol, and N‐propylethanolamine were measured between 298.15 and 313.15 K with 5 K increment. Based on the experimental values and using the van't Hoff equation, thermodynamic properties such as the standard state changes of enthalpy, entropy, and Gibbs free energy were calculated. Using computational chemistry calculations, the amine that is protonated first was predicted. Furthermore, computer‐free group contribution methods such as the original Perrin–Dempsey–Serjeant (PDS), the modified PDS, and the Qian–Sun–Sun–Gao (QSSG) model were used to estimate the dissociation constants of the studied amines at 298.15 K. The QSSG provided the most accurate results. Finally, this work utilized an artificial neural network for estimating the pKa values, which were in excellent agreement with the experimental data.
Visceral adiposity index is a better predictor to discriminate metabolic syndrome than other classical adiposity indices among young adults
Authors: Vega‐Cárdenas Mariela , Teran‐Garcia Margarita , Vargas‐Morales Juan Manuel , Padrón‐Salas Aldanely , Aradillas‐García Celia 
Published: October 2022

AbstractBackgroundVisceral adiposity index (VAI) has been identified as a cardiometabolic risk marker in children and adolescents which reflects abdominal fat distribution. The aim of the present study was to evaluated the predictive capacity of VAI, a body shape index (ABSI), atherogenic index of plasma (AIP), and triglycerides and glucose index (TyG index) compared with classical anthropometric measurements to discriminate metabolic syndrome (MetS).MethodsThis retrospective study included 1372 individuals. Anthropometric, clinical, and biochemical measurements were used to screen the prevalence of MetS components and to calculate VAI, ABSI, TyG index, and AIP.ResultsThe discriminatory capacity among the variables was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). VAI was the variable with the highest AUC with 0.932 CI 95% (0.917–0.948), followed by AIP with 0.914 CI 95% (0.897–0.931), and TyG index with 0.889 CI 95% (0.871–0.908).ConclusionVAI is a promising tool to identify MetS in the late adolescence setting. Among the novel adiposity indexes VAI, AIP, TyG index are able to determine MetS presence, while ABSI is not capable.
Disease mechanisms of monogenic congenital anomalies of the kidney and urinary tract
Authors: Connaughton Dervla M. , Hildebrandt Friedhelm 
Published: October 2022

AbstractCongenital Anomalies of the Kidney and Urinary Tract (CAKUT) is a developmental disorder of the kidney and/or genito‐urinary tract that results in end stage kidney disease (ESKD) in up to 50% of children. Despite the congenital nature of the disease, CAKUT accounts for almost 10% of adult onset ESKD. Multiple lines of evidence suggest that CAKUT is a Mendelian disorder, including the observation of familial clustering of CAKUT. Pathogenesis in CAKUT is embryonic in origin, with disturbances of kidney and urinary tract development resulting in a heterogeneous range of disease phenotypes. Despite polygenic and environmental factors being implicated, a significant proportion of CAKUT is monogenic in origin, with studies demonstrating single gene defects in 10%–20% of patients with CAKUT. Here, we review monogenic disease causation with emphasis on the etiological role of gene developmental pathways in CAKUT.
Spontaneous Assembly and Three‐Dimensional Stacking of Antiaromatic 5,15‐Dioxaporphyrin on HOPG
Authors: Chen Tsang‐Wei Matt , Tanaka Yuki , Kametani Yohei , Cheng Kum‐Yi , Lin Chih‐Hsun , Lin Yi Rick , Hsu Ting‐Rong , Chen Zuqian , Hao Jiping , Mori Shigeki , Shiota Yoshihito , Yoshizawa Kazunari , Furuta Hiroyuki , Shimizu Soji , Chen Chun‐hsien 
Published: October 2022

AbstractAntiaromatic compounds have recently received considerable attention because of their novel properties such as narrow HOMO–LUMO gaps and facile formation of mutual stacking. Here, the spontaneous assembly of antiaromatic meso‐2‐thienyl‐substituted 5,15‐dioxaporphyrin (DOP‐1) is scrutinized at the liquid‐solid interface by scanning tunneling microscopy (STM). Polymorphism in monolayers characterized by the orthogonal and parallel assemblies is found at the low concentration of 0.05 mM. The parallel assembly is more stable and dominantly formed at higher concentrations. Aggregation was observed at concentrations >0.2 mM, and the STM images of the aggregates implied the formation of stacked layers. The intrinsic electronic structures of the mutually stacked bilayer generated by applying an electric pulse to the monolayer were probed by scanning tunneling spectroscopy to reveal the narrowing of the HOMO–LUMO gap by about 20 % compared with the monolayer, thus suggesting significant molecular orbital interactions.
Alkaline Tolerant Antifreezing Additive Enabling Aqueous Zn||Ni Battery Operating at −60 °C
Authors: Chen Shengmei , Peng Chao , Xue Dongfeng , Ma Longtao , Zhi Chunyi 
Published: October 2022

AbstractAlkaline aqueous batteries such as the Zn||Ni batteries have attracted substantial interests due to their merits of high energy density, high safety and low cost. However, the freeze of aqueous electrolyte and the poor cycling stability in alkaline condition have hindered their operation in subzero conditions. Herein, we construct a stable aqueous electrolyte with lowest freezing point down to −90 °C by adding dimethyl sulfoxide (DMSO) as alkaline tolerant antifreezing additive into 1 M KOH solution. Meanwhile, we find the DMSO can also retard Zn anode corrosion and prevent Zn dendrite formation in alkaline condition, which enables the Zn plating/stripping over 700 h cycle at 1 mA cm−2 and 0.5 mAh cm−2. The fabricated Zn||Ni battery can endure low working temperature even down to −60 °C and its dischage capacity retains 84.1 % at −40 °C, 60.6 % at −60 °C at 0.5 C. Meanwhile, it can maintain 600 cycles with a specific capacity retention of 86.5 % at −40 °C at 2 C.
Thiamyxine: Struktur und Biosynthese myxobakterieller RNA‐Virus Inhibitoren**
Authors: Haack Patrick A. , Harmrolfs Kirsten , Bader Chantal D. , Garcia Ronald , Gunesch Antonia P. , Haid Sibylle , Popoff Alexander , Voltz Alexander , Kim Heeyoung , Bartenschlager Ralf , Pietschmann Thomas , Müller Rolf 
Published: October 2022

AbstractUnsere Suche nach neuen myxobakteriellen Naturstoffen führte zur Entdeckung der Thiamyxine, thiazol‐ und thiazolinreichen nichtribosomalen Peptid‐Polyketid‐Hybriden mit potenter antiviraler Aktivität. Vier Mitglieder dieser noch unbeschriebenen Naturstofffamilie wurden isoliert. Darunter auch ein offenkettiges Derivat, welches eine Glycerin‐Einheit am C‐Terminus trägt. Basierend auf der Analyse des Thiamyxin‐Biosythesegenclusters und unterstützt durch Fütterungsexperimente mit isotopenmarkierten Vorläufersubstanzen, beschreiben wir hier neben der Strukturaufklärung der Thiamyxine ein Biosynthesemodell. Als Besonderheit ist der Einbau eines 2‐(Hydroxymethyl)‐4‐methylpent‐3‐ensäure‐Bausteins durch die Polyketidsynthase zu nennen, die auch eine GCN5‐verwandte N‐Acetyltransferase‐Decarboxylase‐Domäne beinhaltet. Die Thiamyxine zeigen in mit Corona‐, Zika‐ und Dengue‐Virus infizierten Zellkulturmodellen eine deutliche Hemmung von RNA‐Viren. Ihre Potenz, bis zu einer halb‐maximalen Hemmkonzentration von 560 nM, in Verbindung mit milderen zytotoxischen Wirkungen auf menschliche Zelllinien, indizieren ein Potenzial für die weitere Entwicklung der Thiamyxine.