bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM PENENTU KEPUTUSAN PENGGANTIAN BARANG INVENTARIS DI SDN 1 ALAS BAYUR MENGGUNAKAN METODE WEIGHTED PRODUCT BERBASIS WEBSITE
Authors: Erina Freshtiyana  , Yoyon Arie Budi  
Published: April 2022

SDN 1 ALAS BAYUR merupakan sekolah dasar yang terletak didesa Alasbayur kecamatan mlandingan kabupaten Situbondo yang didirikan sejak 2 januari tahun 1969. Sebagai sekolah yang masih terletak disesa terpencil, SDN 1 Alas Bayur masih memiliki kendala dalam beberapa hal, khususnya bagi pengurus inventaris barang sekolah yang masih dilakukan manual dan memakan waktu yang cukup lambat untuk mengelola barang mana yang seharusnya sudah diganti atau tidak perlu lagi. Oleh karena itu sangat dibutuhkan untuk membangun sistem penentu keputusan SDN 1 Alasbayur dengan upaya memperbaiki sistem pengelolaan inventaris barang yang ada di SDN 1 Alas Bayur. Dalam penelitian tersebut dilakukan pengumpulan data dengan cara melakukan sesi wawancara kepada salah satu staff di SDN 1 Alasbayur. Dalam pembuatan sistem informasi ini penulis menggunakan bahasa pemograman PHP sebagai alat pemograman pada server dan MySQL untuk mengolah database yang digunakan pada sistem penentu keputusan barang inventaris di SDN 1 Alasbayur. Dalam sistem tersebut akan menampilkan informasi tentang data barang apa saja yang ada di SDN 1 Alasbayur.Dengan demikian penelitian ini akan menghasilkan sebuah Sistem penentu keputusan penggantian barang inventaris di SDN 1 Alas Bayur menggunakan metode WP berbasis website.
MoC Quantum Dots@N‐Doped‐Carbon for Low‐Cost and Efficient Hydrogen Evolution Reaction: From Electrocatalysis to Photocatalysis
Authors: Zhou Xunfu , Tian Yuhui , Luo Jin , Jin Bei , Wu Zhijun , Ning Xiaomei , Zhan Liang , Fan Xuliang , Zhou Tao , Zhang Shanqing , Zhou Xiaosong 
Published: April 2022

AbstractSustainable and highly efficient non‐noble metal catalysts could facilitate the realization of closed‐loop and carbon‐neutral hydrogen (H2) economy via low‐cost electrocatalytic (EC) or photocatalytic (PC) H2 evolution reaction (HER) from water. Herein, molybdenum carbide (MoC) quantum dots onto N‐doped porous carbon are in situ synthesized and immobilized, resulting in a bifunctional catalyst MoC@NC. Density functional theory calculation suggests that the targeted catalyst has a suitable Gibbs free‐energy (ΔGH*) for the adsorption of atomic hydrogen, which is beneficial to both EC and PC HERs. For EC HER, the as‐prepared MoC@NC catalyst delivers a low overpotential of 160 mV at −10 mA cm−2 and a remarkable H2 evolution rate in alkaline electrolytes. For PC HER, MoC@NC couple with 2D graphitic carbon nitride (g‐C3N4), which significantly reduces the PC HER energy barrier and enhances the separation efficiency of photogenerated carriers, and consequently, achieves an outstanding photocatalytic H2 evolution rate of 1709 µmol h−1 g−1, which is 213‐fold of that of pure g‐C3N4. This study paves a new avenue for developing sustainable non‐noble metal catalysts for both EC and PC HERs.
Multifunctional Double‐Layer Composite Hydrogel Conduit Based on Chitosan for Peripheral Nerve Repairing
Authors: Deng Pengpeng , Chen Feixiang , Zhang Haodong , Chen Yun , Zhou Jinping 
Published: April 2022

AbstractPeripheral nerve regeneration and functional recovery is a major challenge in clinical practice. Nerve conduit is an effective treatment for peripheral nerve repair, but the traditional hollow nerve conduit is not satisfactory in peripheral nerve repair due to the limitation of cell migration and nutrient transport. Herein, the double cross‐linked hydrogels with injectable, self‐healing, and conductive properties are synthesized by the Schiff base reaction between polyaniline‐modified carboxymethyl chitosan and aldehyde‐modified Pluronic F‐127 (F127‐CHO), and the hydrophobic interaction of F127‐CHO. The conductive hydrogel is injected into the cavity of chitosan conduit prepared by electrodeposition. The inner conductive hydrogel and the outer chitosan conduit are formed into a whole through the Schiff base reaction to obtain a double‐layer composite hydrogel nerve conduit. The double‐layer composite hydrogel neural conduit loaded with 7,8‐dihydroxyflavone (DHF) has excellent degradability, biocompatibility, antioxidant activity, and Schwann cell proliferation activity. In the rat sciatic nerve defect model, the double‐layer composite hydrogel nerve conduit significantly promotes sciatic nerve regeneration compared with the chitosan hollow conduit. Surprisingly, the repair ability of double‐layered hydrogel nerve conduit loaded with DHF is comparable to that of autologous transplantation. Therefore, this multifunctional double‐layer composite hydrogel conduit has great potential for peripheral nerve repairing.
Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials
Authors: Soltani Dehnavi Shiva , Eivazi Zadeh Zahra , Harvey Alan R. , Voelcker Nicolas H. , Parish Clare L. , Williams Richard J. , Elnathan Roey , Nisbet David R. 
Published: April 2022

AbstractThe incorporation of nanotechnology in regenerative medicine is at the nexus of fundamental innovations and early‐stage breakthroughs, enabling exciting biomedical advances. One of the most exciting recent developments is the use of nanoscale constructs to influence the fate of cells, which are the basic building blocks of healthy function. Appropriate cell types can be effectively manipulated by direct cell reprogramming; a robust technique to manipulate cellular function and fate, underpinning burgeoning advances in drug delivery systems, regenerative medicine, and disease remodeling. Individual transcription factors, or combinations thereof, can be introduced into cells using both viral and nonviral delivery systems. Existing approaches have inherent limitations. Viral‐based tools include issues of viral integration into the genome of the cells, the propensity for uncontrollable silencing, reduced copy potential and cell specificity, and neutralization via the immune response. Current nonviral cell reprogramming tools generally suffer from inferior expression efficiency. Nanomaterials are increasingly being explored to address these challenges and improve the efficacy of both viral and nonviral delivery because of their unique properties such as small size and high surface area. This review presents the state‐of‐the‐art research in cell reprogramming, focused on recent breakthroughs in the deployment of nanomaterials as cell reprogramming delivery tools.
Tailoring the Solvation Sheath of Cations by Constructing Electrode Front‐Faces for Rechargeable Batteries
Authors: Chang Zhi , Yang Huijun , Qiao Yu , Zhu Xingyu , He Ping , Zhou Haoshen 
Published: April 2022

AbstractSolvent molecules within the solvation sheath of cations (e.g., Li+, Na+, Zn2+) are easily to be dehydrogenated especially when coupled with high‐voltage cathodes, and lead to detrimental electrolytes decompositions which finally accelerate capacity decays of rechargeable batteries. Tremendous efforts are devoted to tackle with this long‐lasting issue. Among them, salt‐concentrated strategies are frequently employed to tailor the solvation sheath of cations and improve the stabilities of electrolytes. However, the cost challenges caused by adding extra dose of expensive salts, additives/cosolvents in preparing highly concentrated electrolytes, hinder their further utilizations to some extent. Introducing porous materials‐based electrode front‐faces on the surface of electrodes even within dilute electrolytes can transfer the high‐energy‐state desolvated solvents from the reactive electrodes to the nonconductive porous material surfaces, thus eliminate the contact chances between desolvated solvents and electrode materials, and greatly reduce solvents‐related decomposition issues. Herein, recent advances in using electrode front‐faces to tailor the solvation sheath of metal ions for rechargeable batteries are discussed. Finally, perspectives to the future challenges and opportunities of constructing electrode front‐faces to tailor the solvation sheath of cations by constructing electrode front‐face for rechargeable batteries are provided.
Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit‐on‐a‐Chip Model
Authors: Tuerlings Margo , Boone Ilja , Eslami Amirabadi Hossein , Vis Michelle , Suchiman Eka , van der Linden Enrike , Hofmann Sandra , Nelissen Rob , den Toonder Jaap , Ramos Yolande , Meulenbelt Ingrid 
Published: April 2022

AbstractGiven the multi‐tissue aspects of osteoarthritis (OA) pathophysiology, translation of OA susceptibility genes towards underlying biological mechanism and eventually drug target discovery requires appropriate human in vitro OA models that incorporate both functional bone and cartilage tissue units. Therefore, a microfluidic chip is developed with an integrated fibrous polycaprolactone matrix in which neo‐bone and cartilage are produced, that could serve as a tailored human in vitro disease model of the osteochondral unit of joints. The model enables to evaluate OA‐related environmental perturbations to (individual) tissue units by controlling environmental cues, for example by adding biochemical agents. After establishing the co‐culture in the system, a layer of cartilaginous matrix is deposited in the chondrogenic compartment, while a bone‐like matrix is deposited between the fibers, indicated by both histology and gene expression levels of collagen type 2 and osteopontin, respectively. As proof‐of‐principle, the bone and cartilaginous tissue are exposed to active thyroid hormone, creating an OA disease model. This results in increased expression levels of hypertrophy markers integrin‐binding sialoprotein and alkaline phosphatase in both cartilage and bone, as expected. Altogether, this model could contribute to enhanced translation from OA risk genes towards novel OA therapies.
High‐Throughput Raman‐Activated Cell Sorting in the Fingerprint Region
Authors: Lindley Matthew , Gala de Pablo Julia , Peterson Walker , Isozaki Akihiro , Hiramatsu Kotaro , Goda Keisuke 
Published: April 2022

AbstractCell sorting is the workhorse of biological research and medicine. Cell sorters are commonly used to sort heterogeneous cell populations based on their intrinsic features. Raman‐activated cell sorting (RACS) has recently received considerable interest by virtue of its ability to discriminate cells by their intracellular chemical content, in a label‐free manner. However, the broad deployment of RACS beyond lab‐based demonstrations is hindered by a fundamental trade‐off between throughput and measurement bandwidth (i.e., cellular information content). Here this trade‐off is overcome and broadband RACS in the fingerprint region (300–1600 cm−1) with a record high throughput of ≈50 cells per second is demonstrated. This represents a 25× throughput increase compared to previous demonstrations of broadband fingerprint‐region RACS outside the resonance Raman regime. To show the utility of the RACS, real‐time label‐free sorting of microalgal cells based on their accumulation of carotenoids and polysaccharide granules is demonstrated. These results hold promise for medical, biofuel, and bioplastic applications.
Reconfigurable Spoof plasmonic Coupler for Dynamic Switching between Forward and Backward Propagations
Authors: Liu Xinyu , Lei Yi , Zheng Xin , Ren Yi , Gao Xinxin , Zhang Jingjing , Cui Tie Jun 
Published: April 2022

AbstractA reconfigurable coupler constructed using two spoof surface plasmon polariton (SSPP) waveguides and a spoof localized surface plasmon (SLSP) resonator to achieve switching between the forward and backward coupling of SSPP waves is proposed. By changing the bias voltage applied to the varactor diodes loaded in the SSPP waveguide, the dispersion of the plasmonic structure is adjusted to achieve a reversed group velocity. Consequently, the direction of the coupled SSPP waves can be dynamically controlled at the same operating frequency. The tunability of this coupler can be further improved by incorporating varactor diodes into the SLSP resonator, where forward–backward coupling can be achieved at multiple frequencies.
Phase Change Nanoelectromechanical Relay for Nonvolatile Low Leakage Switching
Authors: Best James T. , Masud Mohammad Ayaz , de Boer Maarten P. , Piazza Gianluca 
Published: April 2022

AbstractThe design, modeling, and experimental validation of a highly scalable phase change electromechanical relay are present. The Phase Change NEMS Relay (PCNR) is a nonvolatile mechanical relay actuated by the volumetric expansion of phase change material. GeTe is used as the active phase change material, and nonvolatile relay states are changed by converting it between amorphous and crystalline phases, which differ in volume by 10%. Phase conversion is induced by Joule heating an adjacent metal layer. Finite element analysis (FEA) models are developed to predict actuator temperature distributions and quench times for varied actuation pulses. Additional models are developed to simulate actuator deflection including reflow of molten phase change material during an actuation pulse. The smallest fabricated device has a heater footprint of 3 µm × 1 µm, with a 20 nm air‐gap. The FEA model, which calculates the actuation voltage, energy, and ON–OFF current ratio for this device to be 1.1 V, 42 nJ, and 108, respectively, are experimentally verified. A PCNR scaled down to a 15 nm × 5 nm heater footprint with a 2 nm air‐gap is predicted to actuate at 400 mV and 1.7 pJ.
Tailor‐Made Charged Catechol‐Based Polymeric Ligands to Build Robust Fuel Cells Containing Antioxidative Nanoparticles
Authors: Kim Hyunhong , Yook Seung Ho , Kim Ho Young , Choi Yonghoon , Lim Yeongsu , Hwang Yujin , Kim Jeongho , Lee Kwan Young , Jang Seung Soon , Park Jongnam , Kim Jin Young 
Published: April 2022

AbstractCerium oxide nanoparticles (CNPs) are investigated as radical scavengers to increase the durability of polymer electrolyte membrane fuel cells (PEMFCs). However, the practical application of CNPs in PEMFCs is hindered by the low stability of the CNPs during cell operation and the low compatibility of the CNPs with PEM. In this study, as effective antioxidants for PEMs, surface‐engineered CNPs, passivated with dopamine‐based copolymer ligands containing multidentate catechol pendant groups (CNP@DPLs), are reported. The DPLs provide enhanced colloidal and chemical stability in acidic and radical environments, thanks to the robust catechol binding groups and polymer backbone shielding. It is highlighted that they also improved the redox cycling ability of the CNPs, with catechol's additional radical scavenging. Using the CNP@DPLs as a model system, the effect of surface charge is also examined. Negatively charged sulfonic acid‐functionalized CNPs (CNP@DSAs) exhibit the highest compatibility with PEMs. Coherently, the CNP@DSA‐based reinforced composite membrane (CNP@DSA‐RCM) shows the lowest disintegration rate in Fenton's test. The PEMFC based on the CNP@DSA‐RCM outperforms previously reported antioxidant‐based PEMFCs. Importantly, while the pristine PEMFC and Ce salt‐based one undergoes degradation after 40 h, the CNP@DSA based PEMFC retains its performance even after 100 h.
Assessing the performance of non‐associating SAFT‐type equations of state to reproduce vapor pressure, liquid density, enthalpy of vaporization, and liquid heat capacity data of 1800 pure fluids
Authors: Ramírez‐Vélez Nicolás , Privat Romain , Piña‐Martinez Andrés , Jaubert Jean‐Noël 
Published: April 2022

AbstractThe performance of the PC‐SAFT and I‐PC‐SAFT EoS in correlating , , , , and critical coordinates of 1800 pure compounds that consist of 1252 non‐self‐associating and 548 self‐associating compounds is evaluated. The PC‐SAFT equation is able to reproduce and data with a deviation close to 1%, which meets highest standards. The counterpart is however a large deviation on the critical pressure. The I‐PC‐SAFT EoS exactly reproduces the critical pressure and temperature and accurately correlates . Its weak point is a larger liquid density deviation. The key conclusion of this article is however the absence of correlation between the strength of association and the accuracy with which the experimental data were correlated. Regardless of the EoS, poor results are obtained for more than 15% of the non‐self‐associating compounds but 60% of the self‐associating compounds are accurately correlated although no association term was included in the considered EoS.
A novel, de novo intronic variant in POGZ causes White–Sutton syndrome
Authors: Merriweather Ashanta , Murdock David R. , Rosenfeld Jill A. , Dai Hongzheng , Ketkar Shamika , Emrick Lisa , Nicholas Sarah , Lewis Richard A. ,   Undiagnosed Diseases Network, Bacino Carlos A. , Scott Daryl A. , Lee Brendan , Sutton Vernon Reid , Potocki Lorraine , Burrage Lindsay C. 
Published: April 2022

AbstractWhite–Sutton syndrome (WHSUS), which is caused by heterozygous pathogenic variants in POGZ, is characterized by a spectrum of intellectual disabilities and global developmental delay with or without features of autism spectrum disorder. Additional features may include hypotonia, behavioral abnormalities, ophthalmic abnormalities, hearing loss, sleep apnea, microcephaly, dysmorphic facial features, and rarely, congenital diaphragmatic hernia (CDH). We present a 6‐year‐old female with features of WHSUS, including CDH, but with nondiagnostic clinical trio exome sequencing. Exome sequencing reanalysis revealed a heterozygous, de novo, intronic variant in POGZ (NM_015100.3:c.2546‐20T>A). RNA sequencing revealed that this intronic variant leads to skipping of exon 18. This exon skipping event results in a frameshift with a predicted premature stop codon in the last exon and escape from nonsense‐mediated mRNA decay (NMD). To our knowledge, this case is the first case of WHSUS caused by a de novo, intronic variant that is not near a canonical splice site within POGZ. These findings emphasize the limitations of standard clinical exome filtering algorithms and the importance of research reanalysis of exome data together with RNA sequencing to confirm a suspected diagnosis of WHSUS. As the sixth reported case of CDH with heterozygous pathogenic variants in POGZ and features consistent with WHSUS, this report supports the conclusion that WHSUS should be considered in the differential diagnosis for patients with syndromic CDH.
A Dual‐Locked Activatable Phototheranostic Probe for Biomarker‐Regulated Photodynamic and Photothermal Cancer Therapy
Authors: Wei Xin , Zhang Chi , He Shasha , Huang Jiaguo , Huang Jingsheng , Liew Si Si , Zeng Ziling , Pu Kanyi 
Published: April 2022

AbstractActivatable phototheranostics holds promise for precision cancer treatment owing to the “turn‐on” signals and therapeutic effects. However, most activatable phototheranostic probes only possess photodynamic therapy (PDT) or photothermal therapy (PTT), which suffer from poor therapeutic efficacy due to deficient cellular oxygen and complex tumor microenvironment. We herein report a dual‐locked activatable phototheranostic probe that activates near‐infrared fluorescence (NIRF) signals in tumor, triggers PDT in response to a tumor‐periphery biomarker, and switches from PDT to PTT upon detecting a tumor‐core‐hypoxia biomarker. This PDT‐PTT auto‐regulated probe exhibits complete tumor ablation under the photoirradiation of a single laser source by producing cytotoxic singlet oxygen at the tumor periphery and generating hyperthermia at tumor‐core where is too hypoxic for PDT. This dual‐locked probe represents a promising molecular design approach toward precise cancer phototheranostics.
Partial sequence conservation of SARS‐CoV‐2 NSP‐2, NSP‐12, and Spike in stool samples from Abadan, Iran
Authors: Zandi Milad , Soltani Saber , Tabibzadeh Alireza , Nasimzadeh Sepideh , Behboudi Emad , Zakeri Armin , Erfani Yousef , Salmanzadeh Shokrollah , Abbasi Samaneh 
Published: April 2022

AbstractSince the onset of the coronavirus disease 2019 (COVID‐19) pandemic, the clinical manifestations of the virus have undergone many changes. Recently, there have been many reports on gastrointestinal symptoms in COVID‐19 patients. This study is aimed to perform a detailed phylogenetic study and assessment of different SNVs in the RNA genome of viruses isolated from fecal samples of patients with COVID‐19 who have gastrointestinal symptoms, which can help better understand viral pathogenesis. In the present study, 20 fecal samples were collected by written consent from COVID‐19 patients. According to the manufacturer's protocol, virus nucleic acid was extracted from stool samples and the SARS‐CoV‐2 genome presence in stool samples was confirmed by RT–PCR assay. Three viral genes, S, nsp12, and nsp2, were amplified using the reverse transcription polymerase chain reaction (RT–PCR) method and specific primers. Multiple sequencing alignment (MSA) was performed in the CLC word bench, and a phylogenetic tree was generated by MEGA X based on the neighbor‐joining method. Of all cases, 11 (55%) were males. The mean age of the patients was 33.6 years. Diabetes (70%) and blood pressure (55%) were the most prevalent comorbidities. All 20 patients were positive for SARS‐CoV‐2 infection in respiratory samples. Molecular analysis investigation among 20 stool samples revealed that the SARS‐CoV‐2 genome was found among 10 stool samples; only three samples were used for sequencing. The polymorphism and phylogenetic analysis in SARS‐CoV‐2 showed great similarity among all of the evaluated genes with the Wuhan reference sequence and all of the current variants of concern (VOCs). The current study represents a great similarity in polymorphism and phylogenetic analysis of the SARS‐CoV‐2 isolates with the Wuhan reference sequence and all of the current VOC in the particular evaluated partial sequences of S, nsp12, and nsp2.
Characterization of decellularized chicken skin as a tissue engineering scaffold
Authors: Inci Ilyas 
Published: April 2022

AbstractDecellularization has been applied to many tissues and organs to obtain biomaterials for applications in tissue engineering. In this study, decellularization and characterization of chicken skin was performed to provide comprehensive information and in‐depth details on this material as a potential tissue scaffold. Application of Triton X‐100 and sodium dodecyl sulfate (SDS) on tissues at different time intervals as two decellularization protocols were compared according to various aspects, such as removal of cellular components, DNA quantification, protection of extracellular matrix (ECM), mechanical properties, and cytocompatibility, to find the optimum technique during preparation of decellularized scaffolds. The results showed that treatment with SDS revealed better results when compared with Triton X‐100 regarding the preservation of tissue structure and morphology, although there was no difference in the efficiency of decellularization. In general, the tissues decellularized with SDS demonstrated higher levels of cytocompatibility and better mechanical properties in comparison with samples treated with Triton X‐100. In conclusion, this study revealed that decellularized chicken skin is a cheap, abundant, and biocompatible material that supports cell attachment, growth, and proliferation. Therefore, it could be used as a proper candidate to prepare scaffolds for further studies on tissue engineering, especially for skin tissue engineering.