bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACTIVE Study - Safety and feasibility evaluation of external ventricular drainage with ACTIVE fluid exchange in intraventricular hemorrhage: A phase 2, multi-center, randomized controlled trial
Authors: Haldrup Mette , Mohamad Niwar , Rasmussen Mads , Thorup Line , Dyrskog Stig , Simonsen Claus , Miscov Rares , Bjarkam Carsten , Grønhøj Mads , Poulsen Frantz , Korshøj Anders 
Published: September 2022

Abstract
Background
Primary intraventricular hemorrhage (IVH) or IVH secondary to intracerebral- (ICH) and subarachnoid hemorrhage (SAH) are known to have a very poor prognosis, with an expected mortality between 50% and 80%(1). Clearance of IVH might improve patient outcome.
Methods
The study is designed as an investigator-initiated, comparative, prospective, multi-center, 1:1 randomized phase 2 trial evaluating the efficacy and safety of active irrigation in external ventricular drainage (intervention arm - IRRAflow) compared to passive external ventricular drainage (control arm - EVD).
The trial will enroll 58 patients with primary or secondary IVH. Major eligibility criteria include age >18 years of age, IVH documented on head CT or MRI scan (Graeb Score ≥3), need of cerebrospinal fluid drainage, deterioration of consciousness or medical sedation at the time of enrollment, indication for active treatment evaluated by the treating physicians. Exclusion criteria included patients with fixed and dilated pupils, pregnant or nursing women.
The primary endpoint of the study is catheter occlusion evaluated by time to first observed occlusion from VC placement. Secondary endpoints include clearance of ventricular blood as measured by head CT scan, rates of catheter related infection and shunt dependency, length of intensive care unit stay, functional status – Extended Glascow Outcome Scale (eGOS) and modified Rankin scale (mRS) at discharge to rehabilitation and 90 days and mortality rates at 30 days and 90 days.
Discussion
With no standardized treatment for IVH and a poor prognosis, new treatments are needed. IVH patients often need CSF drainage to treat hydrocephalus and to decrease ICP. Standard treatment with passive external ventricular drainage is related to an increased risk of infections which is found in up to 22% of treated cases. The passive VC is known to have a risk of occlusion and is seen in 19-47% of the cases.
We hypothesize that the use of active fluid change using the IRRAflow system will be safe and feasible and will reduce the occlusion- and infection rates in patients with IVH.
Trial registration
ClicalTrials.gov identifier: NCT05204849, registered 15.12.2021, updated 24.01.2022
Cross-cultural translation, validity and reliability of the Turkish version of the Northwick Park Neck Pain Questionnaire
Authors: YILMAZ Ebru , AYDIN Teoman , PASİN Özge 
Published: September 2022

Abstract
Objective
The aim of this study was to translate the Northwick Park Neck Pain Questionnaire (NPQ) into the Turkish language and assess its reliability and validity among patients with neck pain in the Turkish population.
Methods
One hundred subjects (67 female, 33 male) who had chronic neck pain for at least 3 months were included in this study. All participants were asked to complete the NPQ, the Neck Disability Index (NDI) and Neck Pain and Disability Scale (NPDS) on the day of admission, and one week later. The test-retest and internal consistency analyses were applied for the assessment of reliability. The test-retest analysis were assessed by using the Intraclass Correlation Coefficient (ICC) method (95% confidence interval). The value of Cronbach’s alpha coefficient was calculated for internal consistency. Spearman’s correlation coefficient analysis was used for convergent validity.
Results
The mean age was 46.68 ± 12.11 years in the study. The NPQ had a good internal consistency (Cronbach alfa = 0.704) and excellent test-retest reliability (Intraclass correlation coefficient = 0.995). Spearman’s correlation coefficient of the NPQ with the NDI was calculated at 0.648 and Spearman’s correlation coefficient of the NPQ with the NPDS was calculated at 0.811. These results showed that the NPQ is very good correlated with the NDI and the NPDS (p < 0.001).
Conclusion
Our results suggest that the Turkish version of the NPQ is a reliable and valid instrument for Turkish people.
The effect of a phytoestrogen intervention and impact of genetic factors on tumor proliferation markers among Swedish patients with prostate cancer: study protocol for the randomized controlled PRODICA trial
Authors: Ahlin Rebecca , Nybacka Sanna , Josefsson Andreas , Stranne Johan , Steineck Gunnar , Hedelin Maria 
Published: September 2022

Abstract
Background
A high intake of phytoestrogens, found in soy, rye, and seeds, is associated with a reduced risk of a prostate cancer diagnosis. Previously, we found that the overall decreased risk of prostate cancer diagnosis in males with a high intake of phytoestrogens was strongly modified by a nucleotide sequence variant in the estrogen receptor-beta (ERβ) gene. However, we do not know if phytoestrogens can inhibit the growth of prostate cancer in males with established diseases. If there is an inhibition or a delay, there is reason to believe that different variants of the ERβ gene will modify the effect. Therefore, we designed an intervention study to investigate the effect of the addition of foods high in phytoestrogens and their interaction with ERβ genotype on prostate tumor proliferation in patients with prostate cancer.
Method
The PRODICA-trial is a randomized ongoing intervention study in patients with low- and intermediate-risk prostate cancer with Gleason score < 8, prostate-specific antigen (PSA) < 20, and scheduled for radical prostatectomy. The study is conducted at Sahlgrenska University Hospital in Gothenburg, Sweden. The intervention consists of a daily intake of soybeans and flaxseeds (~ 200 mg of phytoestrogens) until the surgery, approximately 6 w. The aim is to recruit 200 participants. The primary outcome is the difference in the proliferation marker Ki-67 between the intervention- and the control groups. The genotype of ERβ will be investigated as an effect-modifying factor. Secondary outcomes include e.g. concentrations of PSA and steroid hormones in blood.
Discussion
The results of the PRODICA-trial will contribute important information on the relevance of increasing the intake of phytoestrogens in patients with prostate cancer who want to make dietary changes to improve the prognosis of their cancer. If genetic factors turn out to influence the effect of the intervention diet, dietary advice can be given to patients who most likely benefit from it. Dietary interventions are cost-effective, non-invasive, and result in few mild side effects. Lastly, the project will provide basic pathophysiological insights which could be relevant in the development of treatment strategies for patients with prostate cancer.
Trial registration:
ClinicalTrials.gov, NCT02759380, Registered on 3 May 2016.
Exploring of Two Different Equated Instability Resistance Training Programs on Balance and Muscle Strength and Power Performance in Pre-pubertal Weightlifters
Authors: Hammami Raouf , Nobari Hadi , Hanen Werfelli , Gene-Morales Javier , Rebai Haithem , Colado Juan Carlos , Ardigò Luca Paolo 
Published: September 2022

Abstract
Background
Although previous research in pediatric populations has reported performance enhancements following instability resistance training, the effects of different volumes on measures of balance, strength and power and lower limb asymmetry remain unclear.
Objective
to compare the effect of two 8-week instability resistance training programs (IRT1: 2 sets x 8 repetitions, 20% one-repetition maximum (1RM); IRT2: 2 sets x 4 repetitions, 40%1RM) in the strength (1RM), power (single-leg jumps), inter-limb asymmetry and balance (center of pressure displacements) of prepubescent weightlifters.
Methods
Thirty-two male athletes (10.94 ± .47 yrs, 17.05 ± .14 kg/m2 and 6.44 ± .93% body-fat) voluntarily participated and combined IRT (front and back squat, lunge and deadlift) with their usual weight-lifting training. Non-parametric tests evaluated the differences between pre- and post-intervention.
Results
Significant improvements were encountered in all the variables for both groups (effect sizes [ES] from 0.46 to 2.60), except the inter-limb asymmetry and the velocity of displacement of the center of pressure, which did not improve in IRT2. It is also worth highlighting that in the single-leg jumps and center of pressure displacements, whereas no-significant differences were observed between IRT1 and IRT2 in the baseline, significant differences appeared in the follow-up measurements.
Conclusion
IRT combined with weightlifting specific training improves the performance of prepubescent weightlifters and, therefore, strength and conditioning coaches may consider including unstable devices with low loads into an overall conditioning program and warm-ups for pre puberal male weightlifters to promote their physical fitness and potentially decrease inter-limb asymmetry.
Trial registration:
This study does not report results related to health care interventions using human participants and therefore it was not prospectively registered.
Phase I Prospective Trial of TAS-102 (trifluridine and tipiracil) and Radioembolization with 90 Y Resin Microspheres for Chemo-refractory Colorectal Liver Metastases
Authors: Fidelman Nicholas , Atreya Chloe E , Griffith Madeline , Milloy M. Alexandra , Carnevale Julia , Cinar Pelin , Venook Alan P , Loon Katherine Van 
Published: September 2022

Abstract
Background
Extrahepatic disease progression limits clinical efficacy of Yttrium-90 (90Y) radioembolization (TARE) for patients with chemotherapy-refractory metastatic colorectal cancer (mCRC). Trifluridine and tipiracil (TAS-102) has overall survival benefit for patients with refractory mCRC and may be a radiosensitizer.
Methods
Sequential lobar TARE using 90Y resin microspheres in combination with TAS-102 in 28-day cycles were used to treat adult patients with bilobar liver-dominant chemo-refractory mCRC according to 3 + 3 dose escalation design with a 12-patient dose expansion cohort. Study objectives were to establish safety and determine maximum tolerated dose (MTD) of TAS-102 in combination with TARE.
Results
A total of 21 patients (14 women, 7 men) with median age of 60 years were enrolled. No dose limiting toxicities were observed. Treatment related severe adverse events included cytopenias (10 patients, 48%) and radioembolization-induced liver disease (2 patients, 10%). Disease control rate in the liver lobes treated with TARE was 100%. Best observed radiographic responses were partial response for 4 patients (19%) and stable disease for 12 patients (57%).
Conclusions
The combination of TAS-102 and TARE for patients with liver-dominant mCRC is safe and consistently achieved disease control within the liver.
Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-β2 signaling axis
Authors: Wang Chuanxin , Li Peilong , Mi Qi , Yan Suzhen , Xie Yan , Cui Zilian , Zhang Shujun , Wang Yifan , Gao Huiru , Wang Yunshan , Li Juan , Du Lutao 
Published: September 2022

Abstract
The regulatory role of circRNAs in cancer metastasis has become a focused issue in recent years. To date, however, the discovery of novel functional circRNAs and their regulatory mechanisms via binding with RBPs in bladder cancer (BC) are still lacking. Here, we screened out CircSLC38A1 based on our sequencing data and followed validation with clinical tissue samples and cell lines. Functional assays showed that circSLC38A1 promoted BC cell invasion in vitro and lung metastasis of mice in vivo. By conducting RNA pull-down, mass spectrum and RIP assays, circSLC38A1 was found to interact with Interleukin enhancer-binding factor 3 (ILF3), and stabilize ILF3 protein via modulating the ubiquitination process. By integrating our CUT&Tag-seq and RNA-seq data, TGF-β2 was identified as the functional target of the circSLC38A1-ILF3 complex. In addition, m6A methylation was enriched in circSLC38A1 and contributed to its upregulation. Clinically, circSLC38A1 was identified in serum exosomes of BC patients and could distinguish BC patients from healthy individuals with a diagnostic accuracy of 0.878. Thus, our study revealed an essential role and clinical significance of circSLC38A1 in BC via activating the transcription of TGF-β2 in an ILF3-dependent manner, extending the understanding of the importance of circRNA-mediated transcriptional regulation in BC metastasis.
Complication Experience during Pregnancy and Place of Delivery among Pregnant Women: A Cross-sectional Study
Authors: Teka Bekelu , Abdulahi Misra , Tsega Merertu , Edilu Birtukan , Ali Rahma , Birhanu Mahilet , Awel Samira , Getnet Masrie , Melaku Yabsira , Kidane Radiet , Taye Abonesh , Tamirat Meseret 
Published: September 2022

Abstract
Background
Unlike other causes such as abortion, obstetric complications like hemorrhage, and hypertensive disorders of pregnancy, which are difficult to resolve for women who give birth out of health facilities are persisted or increased to be the cause of maternal mortality in Ethiopia. Direct obstetric complications resulted in the crude direct obstetric case fatality rate in Ethiopia. This study aimed to assess the relationship between Complication Experience during Pregnancy and Place of Delivery among Pregnant Women.
Method
A community-based cross-sectional study was conducted to assess the baseline information as a part of a randomized control trial study. The sample size that was calculated for the cohort study with the assumptions to detect an increase in a minimum acceptable diet from 11 to 31%, with 95% CIs and 80% power, an intra-cluster correlation coefficient of 0·2 for a cluster size of 10 was used for this study. Statistical analysis was done using SPSS version 22.
Result
The prevalence of self-reported pregnancy-related complications and home delivery were 79(15.9%, CI; 12.7–19.1) and 46.90%( 95%CI; 42.5–51.1) respectively. Women who did not face vaginal bleeding were five times AOR 5.28 (95% CI: 1.79–15.56) more like to give birth at home than those who faced this problem. Women who did not face severe headache were nearly three AOR 2.45(95%CI:1.01–5.97) times more like to give birth at home.
Conclusion
This study concluded that home delivery was high among the study participants whereas pregnancy-related complications such as vaginal bleeding and severe headache were identified as protective factors for facility delivery. Hence, the researchers recommended the incorporation of “storytelling” into the existing health extension program packages to improve facility delivery which shall be applied after the approval of its effectiveness by research.
RSAD2, a pyroptosis-related gene, predicts the prognosis and immunotherapy response for colorectal cancer
Authors: Li Yunxiao , Cui Qianqian , Guo Rong , Ma Zhujun , Wang Yanyan , Xu Xinhua 
Published: September 2022

AbstractBACKGROUND Colorectal cancer (CRC) is one of the most common malignant tumors and exhibits high levels of heterogeneity. Although many treatments and medications are available, the long-term survival rate of CRC patients is far from satisfactory. OBJECTIVE Pyroptosis is closely related to tumor progression, and we aimed to identify pyroptosis-related genes (PRGs) and candidate biomarkers to predict the prognosis of CRC patients. METHODS The expression profiles from Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database were used to identify cancer hallmarks associated with CRC outcomes. WGCNA was performed to explore differential expression genes (DEGs). The STRING database and Cytoscape were used to construct a protein-protein interaction (PPI) network and identify the hub genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) were used to access the functional pathway related to hub genes. Real-Time Quantitative Revers Transcription PCR (RT-qPCR) was chosen to validate the expression of RSAD2 in CRC patients and its effect on pyroptosis. RESULTS 288 co-expression genes in CRC between pyroptosis-related modules and DEGs were identified. Among these hub genes, we selected the top 24 for further analysis and found that RSAD2 was a novel biomarker associated with the progression of CRC. In addition, RSAD2 also affected the tumor immune microenvironment and prognostic of CRC. A risk model for RSAD2 was identified as an independent prognostic predictor. The receiver operator characteristic analysis showed that the model had an acceptable prognostic value for patients with CRC. In addition, RSAD2 also affects the tumor immune microenvironment and prognosis of CRC. We further validated RSAD2 expression in CRC patients and the model using qPCR and the role of RSAD2 in pyroptosis. CONCLUSIONS The comprehensive analysis of pyroptosis-related genes (PRGs) in CRC demonstrated their potential in the tumor-immune microenvironment, clinic-pathological features, and prognosis. Furthermore, this study comprehensively assessed the expression and prognosis of RSAD2 in CRC patients. These findings may offer a new direction for early CRC screening and development of future immunotherapy strategies.
Undernutrition among the children below five years of age in Uganda: A spatial analysis approach
Authors: Maniragaba Vallence Ngabo , Atuhaire Leonard , Rutayisire Peter Clever 
Published: September 2022

Abstract
Background: Undernutrition is a health condition caused by lack of enough food intake, not having enough of the right combination of food nutrients or the body’s failure to utilize the food eaten. This deficiency of food intake results into any of the three health problems namely; stunting, underweight or body wasting. Though the condition affects both the young and old, the young especially the under-fives are at a higher risk. Globally, undernutrition affects more than 149 million under-fives while in Uganda about 3 in every 10 children suffer from undernutrition. The prevalence is unevenly distributed throughout the country. The effects of undernutrition go beyond physical deformities to the child’s poor mental development, poor cognitive development, frequent morbidity and can lead to death.
Methods: This study aimed at establishing spatial variation of undernutrition within Uganda. Anthropometric data on children was obtained from the 2016 Uganda Demographic and Health Survey (UDHS). Data for prevalence rates and percentages of factors affecting undernutrition were combined with the Uganda district shape file to allow spatial analysis. Moran’s I, Getis-Ord (GI*) and GWR respectively, were used to establish the local, global and geographically weighted regressions across the country. ArC GIS (version 10) was used for analysis.
Results: The results indicate that, undernutrition in Uganda shows varies spatially across regions. Evidence of hot spots exist in the North Eastern part of Uganda (the Karamoja region) and the Arua region, cold spot areas exist around the central part of the country while the greatest part of Western Uganda, Northern and Eastern were not significant.
Conclusion: The study reveals that a variation in the distribution of undernutrition throughout the country. Significant spatial patterns associated with undernutrition as were identified through hotspot and cold spot analysis do exist in Uganda. Programmes targeting to reduce the undernutrition of under-fives in Uganda should consider the spatial distribution of undernutrition and its determinants. Prioritization in reducing undernutrition should be given to specific hotspot areas. The spatial intensity of undernutrition and its determinants indicate that focus should be tailored to meet the local needs as opposed to a holistic national approach.
Effects of Aging Treatment on Inconel Specimen 600, 625, 718 Coated with Nickel Chromium Carbide (Cr3C2-NiCr) Using Salt and Acidic Corrosion Methods
Authors: Kumar Vinod 
Published: September 2022

AbstractWhen the material interacts with its surroundings, the deterioration of the material's important properties is referred to as corrosion. Substances used as construction material processing equipment, including the product from it, called materials. These materials can be metals and their alloys, composites, polymers, and ceramics etc. The generally iron and its alloys are the most commonly used materials opted to design different structural component, and thus are largely affected by corrosion in this aspect understanding of corrosion study plays a very vital role. This work includes the use of the thermal spray by D-gun method on three different Inconel materials 600, 625 and 718 are coated with nickel chromium carbide and average thicknesses of 61.34 µm, 67.97 µm and 60.84 µm are obtained respectively. The nickel chromium carbide coated materials then undergo acid corrosion and salt corrosion tests. In Acid corrosion test, the Inconel coated substrates were subjected to laboratory corrosion tests utilizing glass flask and chemicals of the reagent grade. The specimen has a dimension of (15×20×6) mm. The three Inconel specimens 600, 625 and 718 are soaked in three different beakers containing a capacity of 60 ml HCl concentrated for 72 hours. For three different Inconel specimens 600, 625 and 718 using Salt spray test rig salt corrosion test is conducted with temperature range 35°C to 65°C and corrosion rate is calculated. Finally, after the acid corrosion test on three Inconel 625 shows a weight reduction of 0.28% and in salt Inconel 625 shows the average corrosion rate of 38.5 Mpy. Hence it is concluded that Inconel 625 material has maximum coating thickness as compare to Inconel 600 and 718 coated material therefore Inconel 625 exhibited a promising physical and structural properties.
Intelligent Reflecting Surface Assists Secure Communication for Correlated MISO Wiretap Channels
Authors: wang zhejin , rui xianyi 
Published: September 2022

Abstract
We investigate whether intelligent reflecting surface (IRS) is helpful to improve the secrecy rate of communication when the user’s channel and the wiretap channel are correlated. Furthermore, we study whether the location of the IRS will affect secrecy rate under the correlated wiretap channels. However, due to the constraint of the transmission power and IRS phase shift unit modulus, the problem is not easy to solve. To solve it, we use an alternate optimization algorithm and semidefinite programming (SDP) relaxation. From the simulation results we can observe that IRS could effectively resist the influence of channel correlation and increase secrecy rate on secure communication.