bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy: meta-analysis
Authors:   PARANOIA Study Group:,   Writing group:, Halle-Smith James M , Pande Rupaly , Hall Lewis , Hodson James , Roberts Keith J ,   Steering committee:, Arshad Ali , Connor Saxon , Conlon Kevin C P , Dickson Euan J , Giovinazzo Francesco , Harrison Ewen , de Liguori Carino Nicola , Hore Todd , Knight Stephen R , Loveday Benjamin , Magill Laura , Mirza Darius , Mitta Anubhav , Pandanaboyana Sanjay , Perry Rita J , Pinkney Thomas , Samra Jas , Siriwardena Ajith K , Satoi Sohei , Skipworth James , Stättner Stefan , Sutcliffe Robert P , Tingstedt Bobby , Roberts Keith J 
Published: February 2022

Abstract

Background
Data on interventions to reduce postoperative pancreatic fistula (POPF) following pancreatoduodenectomy (PD) are conflicting. The aim of this study was to assimilate data from RCTs.

Methods
MEDLINE and Embase databases were searched systematically for RCTs evaluating interventions to reduce all grades of POPF or clinically relevant (CR) POPF after PD. Meta-analysis was undertaken for interventions investigated in multiple studies. A post hoc analysis of negative RCTs assessed whether these had appropriate statistical power.

Results
Among 22 interventions (7512 patients, 55 studies), 12 were assessed by multiple studies, and subjected to meta-analysis. Of these, external pancreatic duct drainage was the only intervention associated with reduced rates of both CR-POPF (odds ratio (OR) 0.40, 95 per cent c.i. 0.20 to 0.80) and all-POPF (OR 0.42, 0.25 to 0.70). Ulinastatin was associated with reduced rates of CR-POPF (OR 0.24, 0.06 to 0.93). Invagination (versus duct-to-mucosa) pancreatojejunostomy was associated with reduced rates of all-POPF (OR 0.60, 0.40 to 0.90). Most negative RCTs were found to be underpowered, with post hoc power calculations indicating that interventions would need to reduce the POPF rate to 1 per cent or less in order to achieve 80 per cent power in 16 of 34 (all-POPF) and 19 of 25 (CR-POPF) studies respectively.

Conclusion
This meta-analysis supports a role for several interventions to reduce POPF after PD. RCTs in this field were often relatively small and underpowered, especially those evaluating CR-POPF.
Anaplastic lymphoma kinase inhibitors and their effect on the kidney
Authors: Bonilla Marco , Jhaveri Kenar D , Izzedine Hassan 
Published: February 2022

ABSTRACT
Lung cancer is the leading cause of cancer-related mortality and approximately 5% of non–small-cell lung cancer (NSCLC) patients are positive for anaplastic lymphoma kinase (ALK) gene rearrangement or fusion with echinoderm microtubule-associated protein-like 4. ALK inhibitors are the mainstay treatment for patients with NSCLC harboring a rearrangement of the ALK gene or the ROS1 oncogenes. With the recent publication of pivotal trials leading to the approval of these compounds in different indications, their toxicity profile warrants an update. Several ALK-1 inhibitors are used in clinical practice, including crizotinib, ceritinib and alectinib. According to the package insert and published literature, treatment with several ALK-1 inhibitors appears to be associated with the development of peripheral edema and rare electrolyte disorders, kidney failure, proteinuria and an increased risk for the development and progression of renal cysts. This review introduces the different types of ALK inhibitors, focusing on their detailed kidney-related side effects in clinical practice.
Two lineages of bivalve transmissible neoplasia affect the blue musselMytilus trossulusGould in the subarctic Sea of Okhotsk
Authors: Skazina Maria , Odintsova Nelly , Maiorova Mariia , Frolova Lidia , Dolganova Irina , Regel Kira , Strelkov Petr 
Published: February 2022

AbstractThere are increasing findings of the bivalve transmissible neoplasia derived from the Pacific mussel Mytilus trossulus (MtrBTN) in populations of different Mytilus species worldwide. The Subarctic is an area where this disease has not yet been sought despite the fact that Mytilus spp. are widespread there, and M. trossulus itself is a boreal species. We used flow cytometry of the hemolymph, hemocytology, and histology to diagnose disseminated neoplasia in a sample of M. trossulus from Magadan in the subarctic Sea of Okhotsk. Neoplasia was identified in 11 of 214 mussels studied. Using mtDNA COI sequencing, we revealed genotypes identical or nearly identical to known MtrBTN ones in the hemolymph of most of the diseased mussels. Both MtrBTN evolutionary lineages have been identified, the widespread MtrBTN2, and MtrBTN1, so far only known from M. trossulus in British Columbia on the other side of the Pacific from Magadan. In addition, MtrBTN2 was represented by 2 common diverged mtDNA haplolineages. These conclusions were confirmed for selected cancerous mussels by molecular cloning of COI and additional nuclear and mtDNA genes. On the background of high genetic diversity, different cancers were similar in terms of ploidy (range 4.0–5.8 n) and nuclear-to-cell ratio. Our study provides the first description of neoplasia and MtrBTN in mussels from the Sea of Okhotsk and from the Subarctic, of both MtrBTN1 and MtrBTN2 in the same mussel population, and the first direct comparison between these transmissible cancers.
Impaired biventricular contractile reserve in patients with diastolic dysfunction: insights from exercise stress echocardiography
Authors: Claeys Mathias , Petit Thibault , La Gerche Andre , Herbots Lieven , Claus Piet , De Bosscher Ruben , Droogne Walter , Van Cleemput Johan , Voigt Jens Uwe , Delcroix Marion , Janssens Stefan , Willems Rik , Verwerft Jan , Claessen Guido 
Published: February 2022

Abstract

Aims
Cardiac output limitation is a fundamental feature of heart failure with preserved ejection fraction (HFpEF) but the relative contribution of its determinants in symptomatic vs. asymptomatic stages are not well characterized. We aimed to gain insight into disease mechanisms by performing comprehensive comparative non-invasive exercise imaging in patients across the disease spectrum.

Methods and results
We performed bicycle stress echocardiography in 10 healthy controls, 13 patients with hypertensive left ventricular (LV) concentric remodelling and asymptomatic diastolic dysfunction (HTDD), 15 HFpEF patients, and 15 subjects with isolated right ventricular (RV) dysfunction secondary to chronic thromboembolic pulmonary hypertension (CTEPH). During exercise, ventricular performance differed across the groups (all P ≤ 0.01 for interaction). Notably in controls, LV and RV function significantly increased (all P &lt; 0.05) while both LV systolic and diastolic reserve were significantly reduced in HFpEF patients. Likewise, RV systolic reserve was also impaired in HFpEF but not to the extent of CTEPH patients (P &lt; 0.001 between groups). HTDD patients behaved as an intermediary group with borderline LV systolic and diastolic reserve and reduced RV systolic reserve. The increased pulmonary vascular (PV) load in HFpEF and CTEPH patients in combination with impaired RV reserve resulted in RV–pulmonary artery uncoupling during exercise.

Conclusion
The multifaceted decline of cardiac and PV function accompanying disease progression in HFpEF is unmasked by exercise and already emerges in preclinical disease. The revelation of these subtle abnormalities during exercise illustrates the benefit of exercise imaging and creates new prospects for early diagnosis and management.
Pulmonary artery capacitance and pulmonary vascular resistance as prognostic indicators in acute pulmonary embolism
Authors: Quintero-Martinez Juan A , Wysokinski Waldemar E , Cordova-Madera Sandra N , Mogollon Renzo J , Garcia-Arango Mariana , Vlazny Danielle T , Houghton Damon E , Casanegra Ana I , Villarraga Hector R 
Published: February 2022

AbstractAimsThe non-invasive calculation of right ventricular (RV) haemodynamics as pulmonary artery (PA) capacitance (PAC) and pulmonary vascular resistance (PVR) have proved to be feasible, easy to perform, and of high prognostic value. We, therefore, evaluated whether baseline PAC and PVR could predict clinical outcomes for patients with acute pulmonary embolism (PE).Methods and resultsWe prospectively followed 373 patients [mean (standard deviation) age, 64.1 (14.9) years; 58.4% were men, and 27.9% had cancer] who had acute PE and transthoracic echocardiography within 1 day of diagnosis from 1 March 2013 through 30 June 2020. Pulmonary artery capacitance was calculated as left ventricular stroke volume/(PA systolic pressure − PA diastolic pressure). Pulmonary vascular resistance was calculated as (tricuspid regurgitant velocity/RV outflow tract velocity time integral) × 10 + 0.16. These two variables were calculated retrospectively from the values obtained with transthoracic echocardiography. Pulmonary artery capacitance was acquired in 99 (27%) patients and PVR in 65 (17%) patients. Univariable and bivariable logistic regression analyses, and receiver operating characteristic curves were used to evaluate the ability of these haemodynamic measurements to predict mortality up to 6 months. After using bivariable models to adjust individually for age, cancer, and pulmonary hypertension. Pulmonary vascular resistance was associated with all-cause mortality at 3 months [area under the curve (AUC) 0.75, 95% confidence interval (CI) 0.61–0.86; P = 0.01], and 6 months (AUC 0.81; 95% CI 0.69–0.91; P≤ 0.03). Pulmonary artery capacitance was associated with all-cause mortality at 30 days (AUC 0.95; 95% CI 0.82–0.99; P &lt; 0.001) and 3 months (AUC 0.84; 95% CI 0.65–0.99; P = 0.003).ConclusionNon-invasive measurement of RV haemodynamics could provide prognostic information of patients with acute PE. Pulmonary artery capacitance and PVR are potentially important predictors of all-cause mortality in these patients and should be explored in future studies.
Takotsubo syndrome and respiratory diseases: a systematic review
Authors: Li Pengyang , Wang Yanxuan , Liang Jing , Zuo Xinyu , Li Qiuyue , Sherif Akil Adrian , Zhang Jingyi , Xu Yidan , Huang Zirui , Dong Man , Teng Catherine , Pan Su , Dixon Richard A F , Wei Xin , Wu Lingling , Jin Chengyue , Cai Peng , Dai Qiying , Ma Jianjun , Liu Qi 
Published: February 2022

AbstractTakotsubo syndrome (TTS) is a rare cardiovascular condition characterized by reversible ventricular dysfunction and a presentation resembling that of acute myocardial infarction. An increasing number of studies has shown the association of respiratory diseases with TTS. Here, we comprehensively reviewed the literature and examined the available evidence for this association. After searching PubMed, EMBASE, and Cochrane Library databases, two investigators independently reviewed 3117 studies published through May 2021. Of these studies, 99 met the inclusion criteria (n = 108 patients). In patients with coexisting respiratory disease and TTS, the most common TTS symptom was dyspnoea (70.48%), followed by chest pain (24.76%) and syncope (2.86%). The most common type of TTS was apical, accounting for 81.13% of cases, followed by the midventricular (8.49%), basal (8.49%), and biventricular (1.89%) types. Among the TTS cases, 39.82% were associated with obstructive lung disease and 38.89% were associated with pneumonia. Coronavirus disease 2019 (COVID-19), which has been increasingly reported in patients with TTS, was identified in 29 of 42 (69.05%) patients with pneumonia. The overall mortality rate for patients admitted for respiratory disease complicated by TTS was 12.50%. Obstructive lung disease and pneumonia are the most frequently identified respiratory triggers of TTS. Medications and invasive procedures utilized in managing respiratory diseases may also contribute to the development of TTS. Furthermore, the diagnosis of TTS triggered by these conditions can be challenging due to its atypical presentation. Future prospective studies are needed to establish appropriate guidelines for managing respiratory disease with concurrent TTS.
Polycaprolactone/polyvinyl pyrrolidone nanofibers developed by solution blow spinning for encapsulation of chlorogenic acid
Authors: Cao Yang , Shen Chaoyi , Yang Zhichao , Cai Zihan , Deng Zian , Wu Di 
Published: February 2022

Abstract
Study on the application of nanofibers in food active packaging has been a research hotspot in recent years. In this work, solution blow spinning (SBS) was applied to rapidly fabricate the polycaprolactone (PCL), polyvinyl pyrrolidone (PVP), and PCL/PVP nanofibrous films to encapsulate chlorogenic acid (CGA). All films showed uniform and smooth nanofibers, and the Fourier transform infrared spectroscopy and X-ray diffraction proved the success of mixed spinning of PCL and PVP. With the increase of PVP content, the thermal stability of the PCL/PVP nanofibrous films improved. The PCL/PVP (weight ratio of 4:1) film possessed better mechanical properties than PCL and PVP films because of the stronger fiber–fiber interactions. The addition of PCL endowed the hydrophobic surfaces to the PCL/PVP films, and the PCL/PVP films had better water vapor barrier ability. The PCL/PVP (4:1) film exhibited the best long-term continuous release of CGA during 72 h. The PVP nanofibrous film exhibited no inhibition against Staphylococcus aureus and Escherichia coli due to the low encapsulation efficiency, but the PCL and PCL/PVP films exhibited good antimicrobial activity. The above results suggested that the nanofibrous films developed by SBS possess promising prospects in food packaging.
The poplar VQ1 gene confers salt tolerance and pathogen resistance in transgenic Arabidopsis plants via changes in hormonal signaling
Authors: Liu Shifan , Wang Zhaocheng , Wu Jing , Wu Caijuan , Xiong Rui , Xiang Yan , Yan Hanwei 
Published: February 2022

Abstract
The VQ protein family is plant-specific, and is involved in growth, development, and biotic and abiotic stress responses. In this study, we found that the gene expression of poplar VQ1(Potri.001G029700) from Populus trichocarpa varied remarkably under salt stress and hormones associated with disease. A subcellular localization experiment showed that VQ1 was localized in the nucleus and cytomembrane in tobacco. The overexpression of VQ1 in Arabidopsis thaliana enhanced its resistance to salt stress and disease, and was also responsive to it through abscisic acid. Compared with wild-type, transgenic Arabidopsis lines had significantly increased levels of abscisic acid and salicylic acid. The expression of some stress-related genes, such as MPK6, NPR1, and PDF1.2, was significantly up-regulated by salt in transgenic plants, while WRKY70, ABI1, KUP6, and NCED2 were significantly down-regulated by Pseudomonas syringae pv. tomato DC3000 in transgenic plants. Together, these results demonstrate that VQ1 modulates hormonal signaling to confer multiple biotic and abiotic stress responses in transgenic Arabidopsis plants.
A strategy to build a unified data set of moment magnitude estimates for low-to-moderate seismicity regions based on European–Mediterranean data: application to metropolitan France
Authors: Laurendeau A , Clément C , Scotti O 
Published: February 2022

SUMMARYSeismic hazard assessment (SHA) requires earthquake events characterized in terms of the moment magnitude (Mw) scale both in the earthquake catalogues and in the ground motion databases (SHA data sets). However, published Mw estimates for the same event may actually differ due to the adoption of different computation methods, input data, or seismic networks. The main objective of this paper is to develop a novel strategy to assign a unique Mw value for each earthquake and unified to an Mw reference data set that can be applied to low-to-moderate seismicity regions (Mw &lt; 4.5) such as Metropolitan France, the target region of our study. The strategy consists of first collecting all Mw estimated directly by spectral or temporal inversion in a large area of the European–Mediterranean zone, including regional and specific studies in our target region. Then, the sources of Mw estimates are ranked in five different categories, from global to specific studies. A GCMT (Global Centroid Moment Tensor project) standard Mw value is recomputed and a quality flag is assigned depending on the level of the information provided by the sources. Mw estimates are then compared at the European–Mediterranean scale with those provided by the CMT services, chosen as reference. Mw estimates are subsequently corrected for their systematic deviations by progressively including lower magnitude estimates as one moves from high ranked categories to lower ones at each step of the unification procedure. In this work, the collected data set contains 6752 Mw estimates of 4454 shallow events (depth &lt; 40 km) that occurred between 1963 and 2019 and computed by 34 sources (bulletins, publications,…, etc). A unified Mw value could be attributed to 185 events (2.36 ≤ Mw ≤ 5.35) in France and neighbouring regions and 3351 events (3.06 ≤ Mw ≤ 7.57) in the European–Mediterranean region. Finally, we showed that this Mw data set is consistent with European SHA data sets but leads to slightly larger Mw values compared to the French SHA data sets. We also noted that some variability still subsist in Mw data set compared to the existing SHA data sets, especially for Mw &lt; 5.0. This new unified Mw data set is a first step toward the building of future catalogues. It will contribute to greatly improve the coherence of Mw definitions in the next generation of SHA data sets for both metropolitan France and Europe.
Reconstruction of phyllotaxis at the example of digitized red mangrove (Rhizophora mangle) and application to light interception simulation
Authors: Chi Faustino , Streit Katarína , Tavkhelidze Aleksi , Kurth Winfried 
Published: February 2022

Abstract
The function of the arrangement of leaves (phyllotaxy) in a plant increases its ability to perform photosynthesis by positioning the leaves to maximize the surface area available to intercept sunlight. In mangroves species, phyllotaxis is an unexplored phenomenon with the exception of early work from Tomlinson and Wheat. Available red mangrove models do not provide the needed flexibility in representation of tree architecture, which is needed to analyse and reconstruct the detailed architecture of saplings. The objective of the current study was to generate the phyllotactic pattern for red mangrove saplings (Rhizophora mangle) based on our 3D digitized model, in situ measurements, photographic analysis and using an algorithm. Onsite mangrove saplings (between 1 and 2.5 m) from Turneffe Atoll, Belize, were photographed. The above-ground part was digitized using the electromagnetic digitizing equipment (FASTRAK® Polhemus Inc.), high-resolution photos of the leaf arrangements were taken along with field notes and the model was constructed using the software GroIMP (Growth-grammar-related Interactive Modelling Platform). Our algorithm, enriched by probabilistic approaches for the purpose of handling perturbations in phyllotactic patterns, was able to closely refoliate our 3D model. We then used the resulting hybrid model, composed of the digitized branching structure and the algorithmically generated leaves, to simulate the interception of light by individual leaves, employing the stochastic raytracing-based radiation model. This preliminary result allows us to assess and visualize the photosynthetic contributions of single leaves throughout the canopy. Simulations of other processes (flows in xylem and phloem; mechanical behaviour) could be based on such a model.
Calling in “Sick”: COVID-19, Opportunism, Pretext, and Subnational Autocratization
Authors: Stenberg Matthew , Rocco Philip , Farole Safia Abukar 
Published: February 2022

Abstract
As governments sought to manage the coronavirus pandemic, many pursed temporary increases in centralized authority, a general tactic of crisis management. However, in some countries, public health was not the only motive for centralization. The COVID-19 response coincided with broader worldwide trends toward autocratization. Some of these efforts happened while the world was preoccupied with responding to the pandemic without concretely referencing coronavirus; however, in other cases, public-health rationales are clearly and explicitly invoked as a pretext for actions that instead aid the consolidation of regime authority. This has been especially pernicious in subnational politics, where efforts have been made to undermine the ability of opposition parties to fairly contest local and regional politics. This article examines four cases in which political actors either opportunistically used distraction from the COVID-19 pandemic or explicitly invoked public health while seeking to undermine long-term political contestation in their jurisdictions: Hong Kong, Hungary, Uganda, and the United States. We characterize the use of pandemic response as pretext or opportunity for undermining opposition parties, recentralizing political authority in dominant actors, and inhibiting the fair contestation of elections.
Prediagnostic Serum Vitamin D, Vitamin D Binding Protein Isoforms, and Cancer Survival
Authors: Weinstein Stephanie J , Mondul Alison M , Layne Tracy M , Yu Kai , Huang Jiaqi , Stolzenberg-Solomon Rachael Z , Ziegler Regina G , Purdue Mark P , Huang Wen-Yi , Abnet Christian C , Freedman Neal D , Albanes Demetrius 
Published: February 2022

Abstract

Background
Higher circulating vitamin D has been associated with improved overall cancer survival, but data for organ-specific cancers are mixed.

Methods
We examined the association between prediagnostic serum 25-hydroxyvitamin D [25(OH)D], the recognized biomarker of vitamin D status, and cancer survival in 4038 men and women diagnosed with 1 of 11 malignancies during 22 years of follow-up (median = 15.6 years) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Multivariable-adjusted proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between baseline 25(OH)D concentration and subsequent cancer survival; we also stratified on the common vitamin D binding protein isoforms (Gc1f, Gc1s, and Gc2) defined by two single-nucleotide polymorphisms (rs7041 and rs4588) in the vitamin D binding protein gene GC. All P values were 2-sided.

Results
Higher 25(OH)D concentrations were associated with greater overall cancer survival (HR for cancer mortality = 0.83, 95% CI = 0.70 to 0.98 for highest vs lowest quintile; Ptrend = .05) and lung cancer survival (HR = 0.63, 95% CI = 0.44 to 0.90; Ptrend = .03). These associations were limited to cases expressing the Gc2 isoform (HR = 0.38 for Gc2-2, 95% CI = 0.14 to 1.05 for highest vs lowest quintile; Ptrend = .02; and HR = 0.30 for Gc1-2/Gc2-2 combined, 95% CI = 0.16 to 0.56; Ptrend &lt; .001 for overall and lung cancer, respectively).

Conclusions
Higher circulating 25(OH)D was associated with improved overall and lung cancer survival. As this was especially evident among cases with the genetically determined Gc2 isoform of vitamin D binding protein, such individuals may gain a cancer survival advantage by maintaining higher 25(OH)D blood concentrations.