bluuebunny/crossref_metadata_2025_split huggingface dataset:
A self‐limited acute febrile sterile neutrophilic dermatosis (Sweet's‐like syndrome) in a dog featuring target skin lesions with strong upregulation of interleukin‐8 and T‐helper 1 pathway
Authors: Banovic Frane , Stanton James B. 
Published: October 2022

AbstractIn this report, we provide a case of self‐limiting canine acute febrile sterile neutrophilic dermatosis in which the clinical signs featured typical target skin lesions with strong upregulation of T‐helper 1 markers and interleukin‐8, a potent neutrophil chemoattractant. Further, large case series are needed to characterize canine sterile neutrophilic dermatosis.
Evaluation of compounded cidofovir, famciclovir, and ganciclovir for the treatment of feline herpesvirus ocular surface disease in shelter‐housed cats
Authors: Mironovich Melanie A. , Yoon Angela , Marino Morgan E. , Ineck Nikole E. , Liu Chin‐Chi , Carter Renee T. , Lewin Andrew C. 
Published: October 2022

AbstractObjectiveTo assess the efficacy of compounded cidofovir, famciclovir, and ganciclovir for the treatment of feline herpesvirus type 1 (FHV‐1) ocular surface disease.Animals studied132 shelter‐housed cats qPCR positive for FHV‐1.ProceduresA masked placebo‐controlled study design was utilized. Animals were enrolled in one of four treatment groups: topical ocular placebo + oral placebo (n = 32), compounded cidofovir 0.5% ophthalmic solution + oral placebo (n = 32), compounded famciclovir oral solution (90 mg/kg) + topical ocular placebo (n = 32), and compounded ganciclovir 0.15% ophthalmic solution + oral placebo (n = 36). Cats were treated with each medication twice daily for 7 days and were evaluated on Day 1 and Day 8 using an ocular scoring system, body weight, and qPCR for FHV‐1 viral load.ResultsCidofovir significantly decreased viral load from Day 1 to Day 8 compared with placebo (p = .024). Neither famciclovir nor ganciclovir decreased viral load compared with placebo (p = .14,p = .41). There was no significant improvement of ocular scores for any drug group compared with placebo (p = .62). In all groups, 65%–75% of cats improved from Day 1 to Day 8. Juvenile cats had a significant increase in weight gain compared with placebo for cidofovir (p = .025) and ganciclovir (p = .023). All corneal ulcers in placebo animals failed to heal whereas 77% of ulcers in antiviral group animals healed.ConclusionsTopical ophthalmic cidofovir significantly decreased ocular FHV‐1 viral shedding and increased weight gain in juvenile cats. Ganciclovir increased weight gain in juvenile cats. Compounded famciclovir demonstrated limited efficacy for the treatment of FHV‐1 ocular surface disease in shelter‐housed cats.
Contrast‐enhanced ultrasonography for evaluation of the blood perfusion of sciatic nerves in healthy dogs
Authors: Lee Juryeong , Lee Dongjae , Suh Guk‐Hyun , Choi Jihye 
Published: October 2022

AbstractBlood supply to the peripheral nerves is essential for fulfilling their structural and functional requirements. This prospective, experimental, exploratory study aimed to assess the feasibility of contrast‐enhanced ultrasonography (CEUS) for evaluating blood perfusion of the sciatic nerve in normal dogs. Contrast‐enhanced ultrasonography examinations were performed on the bilateral sciatic nerves after bolus injection of Sonazoid™ (0.015 mL/kg) in 12 healthy Beagles for 150 s. Then, qualitative assessment of the wash‐in timing, degree and enhancement patterns, and quantitative measurement of the peak intensity and time to peak intensity were performed from the sciatic nerve. The results were compared to those obtained from the adductor muscle around the nerve and caudal gluteal artery. After contrast agent injection, the sciatic nerve was enhanced at approximately 13–14 s, immediately after wash‐in of the caudal gluteal artery. The peak intensity of the sciatic nerve was significantly lower than that of the caudal gluteal artery and higher than that of the adductor muscle. The time to peak intensity was significantly slower than that of the caudal gluteal artery; but was not significantly different from that of the adductor muscle. There were no significant differences in the peak intensity and time to peak intensity between the left and right sciatic nerves. These results demonstrate the feasibility of CEUS to assess blood perfusion of the sciatic nerve in healthy dogs qualitatively and quantitatively. This result from healthy dogs could serve as a reference for further studies that evaluate the sciatic nerve under pathological conditions.
Water limitation affects weed competitive ability for light. A demonstration using a model‐based approach combined with an automated watering platform
Authors: Moreau Delphine , Busset Hugues , Matejicek Annick , Prudent Marion , Colbach Nathalie 
Published: October 2022

AbstractClimate change is driving the need to investigate responses to water limitation of morphological traits involved in competition for light, the main resource for which crops and weeds compete in conventional temperature and tropical cropping systems, to better understand field crop–weed dynamics. Our objective was to develop an innovative approach to quantify weed species responses to water limitation, using three species. This approach combined (1) key morphological traits involved in competition for light (taken from a mechanistic crop–weed model) as criteria to analyse responses to water limitation and (2) a pot/greenhouse platform allowing automated precision‐watering and daily quantification of soil water availability in each pot. For all species and growth stages, increased plant height per unit of aboveground biomass and production of smaller/thicker leaves were the most noteable responses. Plants with a strong increase in plant height per unit of aboveground biomass in response to water limitation maintained high levels of specific leaf area, even at low soil water availability. Increases in biomass allocation to roots (vs. aboveground parts) and leaves (vs. stems and reproductive organs) were also observed, but not for all species and growth stages. Overall, these effects of water limitation on morphological traits indicate strong interactions between competition for light and water.
Novel Unmanned Aircraft System Propeller Design—Part 1: Using an Unloaded Tip to Reduce Power Requirements and Lower Generated Sound Levels for Propellers Designed for Minimum Induced Drag
Authors: Wisniewski Charles , Van Treuren Kenneth 
Published: October 2022

Abstract
Today, over 500 eVTOL vehicles are being developed for everything from Urban Air Mobility to package delivery. In addition, unmanned aircraft systems (UASs) are used in a variety of applications to include intelligence, surveillance, and reconnaissance (ISR) as well as resupply for the military. Most of these vehicles utilize electric propulsion systems with propellers. Efficient propellers with reduced noise generation are necessary for these vehicles to coexist in urban environments or be used for ISR missions. Traditional propeller design uses blade element momentum theory (BEMT) to minimize induced losses. The current investigation describes a novel propeller design approach that minimizes induced drag by reducing the thrust loading near tip. This reduces the tip vortex strength lowering the sound pressure level (SPL) and power required. A parametric study of 18 propellers examined performance using traditional BEMT design near the hub and progressing to zero thrust loading at the tip. A microphone on a traverse mounted behind the propeller was used to measure the peak SPL and its location in a wind tunnel. The best performing unloaded tip propeller showed 5.2% reduction in power required and 12 dB SPL reduction compared to a commercial propeller at the same test conditions.
Disturbance Modeling and Prediction of Closed-Loop Micro-Actuator Stroke Usage in Dual-Stage Hard Disk Drives
Authors: Chakraborty Manash , Caverly Ryan J. 
Published: October 2022

Abstract
This letter presents a method to model the disturbance environment of a dual-stage hard disk drive (HDD), which is then used to predict the actuator stroke usage (i.e., the range of actuator displacement used) of a closed-loop track-following controller. In particular, a data-driven disturbance modeling approach is proposed and the stochastic interpretation of the H2 norm is used to systematically estimate the micro-actuator (PZT) stroke usage of the HDD controller. Upper- and lower-bound models of the frequency response of the external disturbance environment are used to provide a range of possible stroke usage, which involves a data-driven calibration process. The accuracy of the prediction model is validated in experiments with a controller that differs from the controllers in the calibration data set.
Permeability and Rigidity of Green River Shale Before and After Exposure to Water
Authors: Yildirim Levent Taylan Ozgur , Elsworth Derek , Wang John Yilin 
Published: October 2022

Abstract
Acoustic travel times through Green River shale samples both parallel and perpendicular to bedding are measured to investigate water interactions with Green River shale and the impact of pertinent factors including exposure durations, pore pressure, effective stress, and anisotropy. To assist these analyses, X-ray diffraction (XRD) and permeability are also measured. Understanding petrophysical and rock properties before and after exposure to water is essential to optimize stimulation design in shale reservoirs. The XRD shows that the samples are clay-poor and mainly consist of carbonate minerals. Bedding-parallel and bedding-perpendicular permeability to non-sorbing He are measured before exposure to tap water to analyze permeability evolution under different stress conditions using the pressure transient method. The samples record very low permeabilities at recreated confining stresses, indicating that the shale requires stimulation. The permeability decreases as confining stress increases, while the permeability increases with increasing pore pressure. Acoustic travel time measurements show that compressional and shear wave velocities, and elastic moduli of the samples increase as confining stress increases before samples are exposed to tap water. This results in more rigid samples which exhibit higher fracture conductivity. The samples are saturated with tap water in containers at atmospheric pressure after the initial acoustic travel time measurements. Further acoustic travel time measurements and chemical elemental analysis in tap water show that quartz dissolves from the pore structure of the Green River shale, reducing the acoustic velocities, and elastic moduli of the samples that then exhibit lower rigidity and fracture conductivity.
A Unique Method to Determine Ferrite and Martensite Phase Stress–Strain Curve for Manufacturing Process
Authors: Halim Silvie Tanu , Ng Eu-Gene 
Published: October 2022

Abstract
Finite element (FE) methods have been extensively used to simulate the effects of material’s microstructure during machining processes. However, determination of the individual microstructure phase stress–strain curves is experimentally intensive and difficult to measure. Furthermore, these curves were also affected by heat treatment processes, chemical composition, and the percentage of individual microstructure phases. The objective of this paper is to develop and validate the Micromechanical Adaptive Iteration Algorithm to calculate the individual ferrite and martensite plastic behavior for dual-phase (DP) steel. This method requires a minimum of three experimental stress–strain curves from the same material with three different martensite volume fractions (Vm). Two of the stress–strain curves with different Vm are required to initialize the iteration algorithm to predict the individual plastic behavior of ferrite and martensite. The third stress–strain curve is used to validate the plastic behavior of individual ferrite and martensite for the given DP steel. Following on from here, the proposed algorithm was validated with two different grades of DP steel with 0.088%C and 0.1%C. Validation results show that the approach has consistent prediction capabilities, and the maximum difference observed between predicted and experimental results was 6.5%. The simulated results also show that the degree of strain partitioning between ferrite and martensite decreases with Vm.
Mechanisms of Achilles Tendon Rupture in National Basketball Association Players
Authors: Petway Adam J. , Jordan Matthew J. , Epsley Scott , Anloague Philip 
Published: October 2022

A systematic search was performed of online databases for any Achilles tendon (AT) injuries occurring within the National Basketball Association (NBA). Video was obtained of injuries occurring during competition and downloaded for analysis in Dartfish. NBA athletes (n = 27) were identified with AT rupture over a 30-year period (1991–2021). Of the 27 NBA athletes found to have AT ruptures (mean age: 29.3 [3.3] y; average time in the NBA: 8.5 [3.8] y), 15 in-game videos were obtained for analysis. Noncontact rupture was presumed to have occurred in 12/13 cases. Eight of the 13 athletes had possession of the ball during time of injury. The ankle joint of the injured limb for all 13 athletes was in a dorsiflexed position during the time of injury (47.9° [6.5°]). All 13 athletes performed a false-step mechanism at time of injury where they initiated the movement by taking a rearward step posterior to their center of mass with the injured limb before translating forward. NBA basketball players that suffered AT ruptures appeared to present with a distinct sequence of events, including initiating a false step with ankle dorsiflexion of the injured limb at the time of injury.
Ordovician Japan: geotectonic setting and palaeogeography
Authors: Isozaki Yukio 
Published: October 2022

Abstract
Ordovician Japan formed a mature arc-trench system developed along the palaeo-Pacific (Panthalassa) margin of the Greater South China (GSC) continental block. GSC consists of South China, East China Sea, SW–NE Japan and the Khanka–Jiamusi–Bureya megablock in the Far East; Paleozoic GSC was thus, in total, twice as large as the South China components by themselves (Yangtze and Cathaysia). The Ordovician crust of Proto-Japan comprised coeval arc-related rocks, such as granitoids, supra-subduction zone ophiolites and fore-arc basin strata, although most of them were considerably fragmented. The Ordovician and middle–late Paleozoic fossils from Japan are highly limited but suggest that Proto-Japan was positioned in the low-latitude domains probably of the palaeo-Pacific Ocean in connection to Paleo-Tethys. GSC became separated from Rodinia in the Neoproterozoic, and its Proto-Japan segment evolved as a collision-free subduction margin for nearly 500 myr since the mid-Cambrian. The GSC framework provides critical constraints to the palaeogeographical reconstruction of circum-Pacific continental blocks. First, the Cambro-Ordovician GSC should have been isolated from Australia/India/East Antarctica that formed East Gondwana by a relatively wide ocean domain for keeping ‘subduction potential’. Second, the Cathaysian margin of GSC should have faced to an extensive ocean without major continents since the Cambrian. The palaeo-Pacific is the only possible candidate for this.
Fog index
Authors: Yaffe Philip 
Published: October 2022

Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay.
The Gunning Fog Index is supposed to provide a means of determining how easy or difficult a text will be to read. But does it? Can any formula really provide valid insights into the readability of a text? And if so, does it really matter?
Shared Cancer Dataset Analysis Identifies and Predicts the Quantitative Effects of Pan-Cancer Somatic Driver Variants
Authors: Landau Jakob , Tsaban Linoy , Yaacov Adar , Ben Cohen Gil , Rosenberg Shai 
Published: October 2022

AbstractDriver mutations endow tumors with selective advantages and produce an array of pathogenic effects. Determining the function of somatic variants is important for understanding cancer biology and identifying optimal therapies. Here, we compiled a shared dataset from several cancer genomic databases. Two measures were applied to 535 cancer genes based on observed and expected frequencies of driver variants as derived from cancer-specific rates of somatic mutagenesis. The first measure comprised a binary classifier based on a binomial test; the second was tumor variant amplitude (TVA), a continuous measure representing the selective advantage of individual variants. TVA outperformed all other computational tools in terms of its correlation with experimentally derived functional scores of cancer mutations. TVA also highly correlated with drug response, overall survival, and other clinical implications in relevant cancer genes. This study demonstrates how a selective advantage measure based on a large cancer dataset significantly impacts our understanding of the spectral effect of driver variants in cancer. The impact of this information will increase as cancer treatment becomes more precise and personalized to tumor-specific mutations.Significance:A new selective advantage estimation assists in oncogenic driver identification and relative effect measurements, enabling better prognostication, therapy selection, and prioritization.
A viagem de Abdias Nascimento a Buenos Aires: teatro, política e negritude numa chave transnacional
Authors: Almeida Eliane de Souza , Gionco Pamela 
Published: October 2022

O presente trabalho tem como foco traçar panorama histórico da passagem de Abdias Nascimento pela América Latina, no início dos anos 1940, até sua estada de um ano, em Buenos Aires, como participante nas atividades pós-espetáculos e nas discussões sobre dramaturgia na companhia teatral Teatro Del Pueblo. Acreditamos que esta experiência por parte do então jornalista e depois dramaturgo, ativista e deputado nacional, influenciou diretamente sua concepção do Teatro Experimental do Negro, em seu retorno ao Brasil. Estamos interessados em pensar nesta viagem e nos vínculos estabelecidos com o Teatro del Pueblo a partir de uma perspectiva transnacional e interdisciplinar que nos permita refletir sobre a construção local de arquivos, a circulação de práticas teatrais políticas e a recuperação da memória da comunidade negra na Argentina.
Learning Fair Representations via Rate-Distortion Maximization
Authors: Chowdhury Somnath Basu Roy , Chaturvedi Snigdha 
Published: October 2022

Abstract
Text representations learned by machine learning models often encode undesirable demographic information of the user. Predictive models based on these representations can rely on such information, resulting in biased decisions. We present a novel debiasing technique, Fairness-aware Rate Maximization (FaRM), that removes protected information by making representations of instances belonging to the same protected attribute class uncorrelated, using the rate-distortion function. FaRM is able to debias representations with or without a target task at hand. FaRM can also be adapted to remove information about multiple protected attributes simultaneously. Empirical evaluations show that FaRM achieves state-of-the-art performance on several datasets, and learned representations leak significantly less protected attribute information against an attack by a non-linear probing network.
AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
Authors: Zhao Chunli , Yang Zijing , Chen Zhongrui , Liang Wenqi , Gong Shusheng , Du Zhengde 
Published: October 2022

Abstract
Background
Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellular metabolism. Both the UCP2 and ROS are increased in cochleae in age-related hearing loss (ARHL). However, the role of UCP2 in sensory hair cells in ARHL remains unclear.

Methods
Male C57BL/6 J mice were randomly assigned to an 8-week-old group (Group 1), a 16-week-old group (Group 2), a 16-week-old + adeno-associated virus-inner ear (AAV-ie) group (Group 3), and a 16-week-old + AAV-ie-UCP2 group (Group 4). Mice aged 8 weeks were administrated with AAV-ie-GFP or AAV-ie-UCP2 via posterior semicircular canal injection. Eight weeks after this viral intervention, hearing thresholds and wave-I amplitudes were tested by auditory brainstem response (ABR). Subsequently, the cochlear basilar membrane was dissected for investigation. The number of hair cells and inner hair cell (IHC) synapses, the level of ROS, and the expression of AMP-activated protein kinase α (AMPKα), were assessed by immunofluorescence staining. In addition, mitochondrial function was determined, and the expression of AMPKα and UCP2 proteins was further evaluated using western blotting.

Results
Mice with early-onset ARHL exhibited enhanced oxidative stress and loss of outer hair cells and IHC synapses, while UCP2 overexpression aggravated hearing loss and cochlear pathophysiological changes in mice. UCP2 overexpression resulted in a notable decrease in the number of IHCs and IHC synapses, caused ATP depletion and excessive ROS generation, increased AMPKα protein levels, and promoted IHC apoptosis, especially in the apical and middle turns of the cochlea.

Conclusion
Collectively, our data suggest that UCP2 overexpression may cause mitochondrial dysfunction via energy metabolism, which activates mitochondrion-dependent cellular apoptosis and leads to IHC loss, ultimately exacerbating ARHL.
Cardiac cephalalgia: a narrative review and ICHD-3 criteria evaluation
Authors: Navarro-Pérez María Pilar , Bellosta-Diago Elena , Olesen Jes , Santos-Lasaosa Sonia 
Published: October 2022

Abstract
Background
Cardiac cephalalgia is an unusual condition that occurs during an episode of myocardial ischemia. Information about cardiac cephalalgia is scarce and its characteristics and physiopathology remain unclear. Our aim is to provide a narrative review of clinical characteristics and physiopathology of cardiac cephalalgia and to evaluate the current diagnostic criteria.

Methods
A search through PubMed was undertaken for studies on cardiac cephalalgia published until 20th September 2022. We summarized the literature and provide a comprehensive review of the headache characteristics and possible mechanisms. We also evaluated current International Classification of Headache Disorders third edition diagnostic criteria based on prior reported cases.

Results
In total, 88 cases were found. Headache characteristics were variable. Occipital location and throbbing pain were the most frequently reported. Headache was accompanied in most cases by cardiac symptoms. Criterion B was fulfilled by 98% of cases, criterion C1 by 72%, and criteria C2a and C2b by 37 and 93.2%, respectively. Regarding headache features described in diagnostic criterion C3, ‘moderate to severe intensity’, ‘accompanied by nausea’, ‘not accompanied by photophobia or phonophobia’ and ‘aggravated by exertion’, were reported in 75, 31, 55 and 55% of cases, respectively.

Conclusion
Cardiac cephalalgia characteristics are variable and the headache features described in the diagnostic criterion C3 might not be adequate. Given that cardiac cephalalgia can be the manifestation of a life-threatening condition it is important to increase the knowledge about this entity.