bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left pancreaticoduodenostomy after removal of the right lobe and the head of the pancreas in a cat
Authors: Cruciani Benoît , Touzet Chloé , Robin Elisabeth , Bismuth Camille 
Published: September 2022

AbstractObjectiveTo report a surgical technique for pancreaticoduodenostomy and its outcomes in a cat.AnimalsA 14‐year‐old domestic cat.Study designCase report.MethodsA cat was referred to our hospital with a large abdominal mass. On ultrasonographic examination, this mass was identified as a large fluid‐filled cavity in place of the right pancreatic duct and involved the pancreatic and accessory pancreatic ducts. A small echoic cavity was observed in the left pancreatic lobe. Serous fluid was collected from the large cavity. On cytology, the small cavity was consistent with an abscess. A partial left pancreatectomy was performed to remove the abscess. The large cavity was excised with the remnant of the right pancreatic lobe and body. After ligation of the pancreatic ducts, the left pancreatic duct was isolated and an end‐to‐side pancreaticoduodenostomy was performed.ResultsThe cat recovered without complications. Histological examination was consistent with chronic pancreatitis and peripheral inflammation. No evidence of postoperative pancreatic insufficiency was detected on clinical examination or laboratory findings. A focal ampulla‐like dilation of the pancreatic duct was noted on ultrasonography, with no other complications at the anastomosis. The cat presented 225 days postoperatively with respiratory distress. Multiple nodules were identified throughout the lung parenchyma on radiographs. Abnormalities on ultrasonographic examination included an enlarged liver infiltrated with nodules. Due to poor prognosis, the cat was euthanized. Final histopathological diagnosis was diffuse carcinoma.ConclusionPancreaticoduodenostomy restored pancreaticointestinal continuity after extensive pancreatectomy involving the pancreatic ducts and resulted in long‐term survival in the cat reported here.
SYMBOLIC AI AND GÖDEL'S ONTOLOGICAL ARGUMENT
Authors: Benzmüller Christoph 
Published: September 2022

AbstractOver the past decade, variants of Gödel's ontological arguments have been critically examined using modern symbolic AI technology. Computers have unearthed new insights about them and even contributed to the exploration of new, simplified variants of the argument, which now need to be further investigated by theologians and philosophers. In this article, I provide a brief, informal overview of these contributions and engage in a discussion of the possible future role of AI technology for the rigorous assessment of arguments in theology and philosophy.
Evolution of Force Chains Explains the Onset of Strain Stiffening in Fiber Networks
Authors: Sarkar Mainak , Notbohm Jacob 
Published: September 2022

Abstract
Fiber networks are the primary structural components of many biological structures, including the cell cytoskeleton and the extracellular matrix. These materials exhibit global nonlinearities, such as stiffening in extension and shear, during which the fibers bend and align with the direction of applied loading. Precise details of deformations at the scale of the fibers during strain stiffening are still lacking, however, as prior work has studied fiber alignment primarily from a qualitative perspective, which leaves incomplete the understanding of how the local microstructural evolution leads to the global mechanical behavior. To fill this gap, we studied how axial forces are transmitted inside the fiber network along paths called force chains, which continuously evolve during the course of deformation. We performed numerical simulations on two-dimensional networks of random fibers under uniaxial extension and shear, modeling the fibers using beam elements in finite element software. To quantify the force chains, we identified all chains of connected fibers for which the axial force was larger than a preset threshold and computed the total length of all such chains. To study the evolution of force chains during loading, we computed the derivative of the total length of all force chains with respect to the applied engineering strain. Results showed that the highest rate of evolution of force chains coincided with the global critical strain for strain stiffening of the fiber network. Therefore, force chains are an important factor connecting understanding of the local kinematics and force transmission to the macroscale stiffness of the fiber network.
Identification of Multivariable Hammerstein CARMA System Using Special Test Signals
Authors: Lyu Bensheng , Jia Li , Li Feng , Zhou Chengyu 
Published: September 2022

Abstract
The multivariable Hammerstein controlled autoregressive moving average (CARMA) system contains the sum of bilinear parameter vectors in the identification model, which is difficult to be transformed into a regression form for direct identification. A two-stage identification technique is developed in this article. By using multiple sets of special test signals, this chapter achieves separable identification for the linear subsystem and the nonlinear subsystem. Then, using the property of binary signal input to nonlinear part, parameters of noise model and the linear subsystem can be calculated by recursive extended least squares (RELS) method. To implement the off-line identification, the RELS is used to identify the nonlinear subsystem parameters. Finally, simulation examples illustrate the validity of proposed approach in identifying multivariable Hammerstein CARMA system.
Nonlinear Oscillations of Dielectric Elastomer Actuators With Stretch-Dependent Permittivity
Authors: Xing Xinyu , Chen Lingling , Zhao Chuo , Yang Shengyou 
Published: September 2022

Abstract
Nonlinear oscillations of dielectric elastomers are widely used in the application of dielectric devices. However, the effects of the dielectric permittivity on the oscillations have been overlooked previously. In this article, an analytical model is proposed to study the nonlinear oscillations of dielectric elastomer actuators. The motion equation is obtained by using Hamilton’s principle. Numerical results of the model show that the stretch-dependent dielectric permittivity can change the thickness of the deformed film by about 65% near the resonance frequency. It is anticipated that this work can provide a new way to adjust the nonlinear oscillations and design more robust DE actuators.
Dynamic Modeling Framework for Evaluating Electromagnetic-Electro-Thermal Behavior of Power Conversion System During Load Operation
Authors: Cheng Hsien-Chie , Liu Yan-Cheng 
Published: September 2022

Abstract
This study introduces a modified dynamic multiphysics modeling framework to characterize the electromagnetic-electrothermal (EET) coupled behavior of a power conversion system during a long load operation. The modeling framework extends the prior model with more comprehensive analysis and enhanced computational efficiency and modeling simplicity. This framework incorporates a fully integrated electromagnetic circuit (FIEC) model for extracting parasitics, including self and mutual inductances and also exploring their effect on the switching characteristics and power losses, and a dynamic power loss-temperature thermal (PTT) model for describing the temperature-dependent instantaneous electrical behavior and power loss. Moreover, a simple resistance-capacitance (RC) snubber circuit design is applied to prevent overvoltage and diminish voltage oscillations and spike value during the operation, and their power losses are also assessed and considered in the dynamic EET coupled modeling. Furthermore, the proposed PTT model employs an equivalent thermal RC network to calculate the chip junction temperature with a given power. Additionally, a simple power-temperature relationship derived from the FIEC cosimulation is applied for modeling simplicity and computational efficiency. This framework is tested on a three-phase inverter operating with a 180-deg conduction mode. The proposed FIEC cosimulation and computational fluid dynamics thermal models are validated by double pulse (DPT) and infrared thermography experiments, respectively. Moreover, the PTT model is validated compared with the conventional dynamic coupled electrothermal model. Finally, a design guideline for enhanced thermal performance of the tested power conversion system is sought through parametric analysis.
Research on the Main Controlling Factors for Injection and Production Allocation of Polymer Flooding
Authors: An Zhibin , Zhou Kang , Hou Jian , Wu Dejun , Pan Yuping , Liu Shuai 
Published: September 2022

Abstract
A clear understanding of the main controlling factors for injection and production allocation of polymer flooding is the key to successful differential adjustment for well management in high water cut reservoirs. Generally, sensitivity analysis or design of experiment is used to study the main controlling factors, but the number of adjustment parameters is limited and the optimal results are hard to obtain. Therefore, the paper regards the problem as an inverse problem and studies the controlling factors by combining intelligent optimization and correlation analysis. In general, the correlation between the optimal results of injection and production allocation and each controlling factor is analyzed, and the main controlling factors with the strongest correlation are selected. Results show that injection rate allocation is mainly controlled by pore volume, polymer concentration allocation is mainly controlled by pore volume and formation coefficient, and production rate allocation is mainly controlled by remaining reserves and oil saturation. The case study indicates injection and production adjustment based on the main controlling factors obtains satisfactory development performance while using much less computation cost than that of the intelligent optimization method. The research results provide a good reference for well redistribution adjustment of polymer flooding in large-scale oilfields.
Dots-on-Plots: A Web Application to Analyze Stress–Strain Curves From Tensile Tests of Soft Tissue
Authors: Nesbitt Derek Q. , Nelson Miranda L. , Shannon Kyle S. , Lujan Trevor J. 
Published: September 2022

Abstract
The calculation of tensile mechanical properties from stress–strain curves is a fundamental step in characterizing material behavior, yet no standardized method exists to perform these calculations for soft tissue. To address this deficiency, we developed a free web application called Dots-on-Plots2 that fully automates the calculation of tensile mechanical properties from stress–strain curves. The analyzed mechanical properties include the strength, strain, and energy at four points of interest (transition, yield, ultimate, and rupture), and the linear modulus. Users of Dots-on-Plots can upload multiple files, view and download results, and adjust threshold settings. This study determined a threshold setting that minimized error when calculating the transition point, where the stress–strain curve “transitions” from a nonlinear “toe” region to a linear region. Using the optimal threshold (2% stress deviation from a linear region fit), Dots-on-Plots calculated the transition strains from twenty tensile experiments of human meniscus to be 0.049 ± 0.007, which nearly matched the known transition strain values of 0.050 ± 0.006 (determined using finite element parameter optimization). The sensitivity of the calculated transition strain to the shape of various stress–strain curves was analyzed using sets of model-generated synthetic data. This free web application offers a convenient and reliable tool to systematically enhance the speed, transparency, and consistency of mechanical analysis across biomedical research groups.
Stability of a Cross-Flow Heat-Exchanger Tube With Asymmetric Supports
Authors: Balaji Adireddi , Thani Aswanth , Biswas Saurabh , Vyasarayani C. P. 
Published: September 2022

Abstract
Heat-exchanger tubes subjected to cross-flow experience a fluid elastic instability (FEI) at a critical flow velocity. Baffle plates are often used to provide additional stiffness to long tubes. A cladding is provided between the baffle plates and the tubes to allow for thermal expansion, and the cladding acts like a soft spring. In this paper, we study the contact between the cladding and the tube when the stiffness of the cladding is asymmetric. The tube is modeled as a cantilever Euler–Bernoulli beam, and the fluid forces are represented using an added mass, added damping and a time-delayed displacement term. This results in a partial delay differential equation model for the tube vibration. Using the Galerkin approximation and considering only a single mode, a delay differential equation (DDE) model is developed. However, due to the presence of the delay, the single mode model is also infinite-dimensional. This model contains sign function nonlinearity due to the asymmetry in the contact stiffness of the cladding. The DDE model is essentially nonlinear—that is, no linear approximation exists. However, its solutions are scalable: if q(t) is a solution, then α q(t) is also a solution for any α&gt;0. By exploiting this scalability property of solutions, we use Lyapunov-like exponents to probe the stability of the nonlinear DDE. Further, by numerical continuation, we numerically demonstrate the existence of periodic solutions on the stability boundary. Our stability charts will be beneficial to the designers of heat-exchangers.
Experimental Study of Flow Hydrodynamics Around Circular Cylinder Arrangements Using Particle Image Velocimetry
Authors: Sahu Chitrangini , Eldho T. I. , Mazumder B. S. 
Published: September 2022

AbstractThis study investigates the turbulent flow properties experimentally in the vicinity of two side-by-side circular cylinders, along with the influence of the third cylinder of the same dimension placed in the upstream and successively in the downstream forming an equilateral triangle. Three-dimensional stereoscopic particle image velocimetry (PIV) was employed to collect the instantaneous velocity data around the arrangements. The study highlights the prime parameters of turbulence such as the mean velocities, Reynolds stresses, turbulent kinetic energy (TKE), quadrant analysis, and Q-criteria for vortices, which are responsible for the development of various problems such as scour-hole around the cylindrical pier arrangements, disturbance around industrial and marine structures. The spectral analysis was performed to examine the energy distributions, vortex-shedding frequencies with corresponding Strouhal numbers. Dominant vorticity locations were identified from the contours of Q-criteria. The magnitude of turbulence characteristics was reduced by 15–20% (turbulence intensity reduced by 20% and TKE by 15%) when the third cylinder was placed the upstream of side-by-side cylinder group. Streamlines are also studied to visualize the flow patterns for a better understanding of physics in the presence of the third cylinder. The maximum energy of vortices obtained from the spectrum analysis showed that the vortices generated were less when the third cylinder is placed upstream.
Thermodynamic Suppression Effect of Cavitation Arising in a Hydrofoil in 140 °C Hot Water
Authors: Iga Yuka , Okajima Junnosuke , Yamagichi Yuki , Sasaki Hirotoshi , Ito Yu 
Published: September 2022

Abstract
The thermodynamic suppression effect of cavitation arising in a NACA0015 single hydrofoil is experimentally investigated in water at mainstream temperatures of T∞ = 20 °C to 140 °C in the present study. The cavity length at T∞ = 140 °C is shorter than that at T∞ = 20 °C at a constant cavitation number for all cavity patterns from inception to supercavitation. On the other hand, the cavity length at T∞ = 80 °C is slightly shorter than that at 20 °C in a certain region in which unsteady sheet-cloud cavitation occurs. This indicates that the thermodynamic suppression effect appears easily in unsteady cavitation. In addition, the temperature reduction inside cavities in water is accurately measured using thermistors, which are inserted from the sidewall directly into the cavity. The temperature measurement is performed at a mainstream temperature of less than 80 °C due to limitation of calibration for the sensor. The temperature reduction at 140 °C is then predicted from the measured cavity length. It is shown that the temperature reduction inside the cavity is approximately ΔT = 0.3 °C at T∞ = 80 °C and ΔT = 0.05 °C at T∞ = 20 °C under supercavitation conditions. The predicted temperature reduction inside the cavity is ΔT = 1.1 K at T∞ = 140 °C under supercavitation conditions. Finally, Fruman's prediction equation for ΔT is examined by fitting to the measured and predicted ΔT values with assuming a volume coefficient of evaporation CQ as a fitting parameter.
Fetal alcohol spectrum disorder resources for health professionals: a scoping review protocol
Authors: Okurame Josephine Chidinma , Cannon Lisa , Carter Emily , Thomas Sue , Elliott Elizabeth J , Rice Lauren J 
Published: September 2022

IntroductionPeople with fetal alcohol spectrum disorder (FASD) encounter a range of health and allied health providers and require specialised support to ensure health services are provided safely and effectively. Not all health professionals possess the knowledge or expertise required for the identification, assessment, referral and management of FASD. Accessible resources for understanding and managing FASD can help create awareness in health professionals and ensure patients receive the correct diagnosis and timely access to the necessary supports and services. The aim of this scoping review is to identify and analyse FASD resources for health professionals.Methods and analysisA comprehensive search of eight databases (MEDLINE, Scopus, PsycINFO, CINAHL, PubMED, EMBASE, Web of Science and Trip Medical Database) and nine grey literature databases (FASD Hub, NOFASD Australia, National Organisation for FASD, FASD United, HealthInfoNet, Proof Alliance, Child Family Community Australia, Foundation for Alcohol Research & Education and the Australian Department of Health websites) will be conducted using three search engines including PubMed, Ovid and Google advanced search (search dates: October 2021 to May 2022). Consultations will also be carried out with international and national experts in the diagnosis/management of FASD to obtain any additional relevant published or unpublished resources. Inclusion criteria were developed to guide the selection of resources that are publicly available, primarily focused on FASD and curated for health professionals for the identification, management or referral of FASD. Critical appraisal process will be executed using the Appraisal of Guidelines for REsearch & Evaluation II (AGREE II) tool to assess the quality of selected resources.Ethics and disseminationEthical approval is not required for the scoping review. Scoping review results will be presented at relevant national and international conferences and published in peer-reviewed journals. Search results will be made available to ensure reproducibility and transparency.
Elicitation of stem-like CD8+T cell responses via lymph node-targeted chemoimmunotherapy evokes systemic tumor control
Authors: Manspeaker Margaret P , O'Melia Meghan J , Thomas Susan N 
Published: September 2022

BackgroundTumor-draining lymph nodes (TdLNs) are critical in the regulation of local and systemic antitumor T cell immunity and are implicated in coordinating responses to immunomodulatory therapies.MethodsBiomaterial nanoparticles that deliver chemotherapeutic drug paclitaxel to TdLNs were leveraged to explore its effects in combination and immune checkpoint blockade (ICB) antibody immunotherapy to determine the benefit of TdLN-directed chemoimmunotherapy on tumor control.ResultsAccumulation of immunotherapeutic drugs in combination within TdLNs synergistically enhanced systemic T cell responses that led to improved control of local and disseminated disease and enhanced survival in multiple murine breast tumor models.ConclusionsThese findings suggest a previously underappreciated role of secondary lymphoid tissues in mediating effects of chemoimmunotherapy and demonstrate the potential for nanotechnology to unleashing drug synergies via lymph node targeted delivery to elicit improved response of breast and other cancers.
Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naïve and PD-1 antibody-experienced patients with melanoma (MEL64)
Authors: Vavolizza Rick D , Petroni Gina R , Mauldin Ileana S , Chianese-Bullock Kimberly A , Olson Walter C , Smith Kelly T , Dengel Lynn T , Haden Kathleen , Grosh William W , Kaur Varinder , Varhegyi Nikole , Gaughan Elizabeth M , Slingluff Craig L 
Published: September 2022

BackgroundA vaccine containing 6 melanoma-associated peptides to stimulate helper T cells (6MHP) is safe, immunogenic, and clinically active. A phase I/II trial was designed to evaluate safety and immunogenicity of 6MHP vaccines plus programmed death 1 (PD-1) blockade.Participants and methodsParticipants with advanced melanoma received 6MHP vaccines in an incomplete Freund’s adjuvant (6 vaccines over 12 weeks). Pembrolizumab was administered intravenously every 3 weeks. Tumor biopsies at baseline and day 22 were analyzed by multiplex immunohistochemistry. Primary end points were safety (Common Terminology Criteria for Adverse Events V.4.03) and immunogenicity (ex vivo interferon-γ ELISpot assay). Additional end points included changes in the tumor microenvironment (TME) and clinical outcomes.ResultsTwenty-two eligible participants were treated: 6 naïve to PD-1 antibody (Ab) and 16 PD-1 Ab-experienced. Median follow-up was 24.4 months. Most common treatment-related adverse events (any grade) included injection site reactions, fatigue, anemia, lymphopenia, fever, elevated aspartate aminotransferase, pruritus, and rash. Treatment-related dose-limiting toxicities were observed in 3 (14%) participants, which did not cross the study safety bound. A high durable T cell response (Rsp) to 6MHP was detected in only one participant, but twofold T cell Rsps to 6MHP were detected in 7/22 (32%; 90% CI (16% to 52%)) by week 13. Objective clinical responses were observed in 23% (1 complete response, 4 partial responses), including 4/6 PD-1 Ab-naïve (67%) and 1/16 PD-1 Ab-experienced (6%). Overall survival (OS) was longer for PD-1 Ab-naïve than Ab-experienced participants (HR 6.3 (90% CI (2.1 to 28.7)). In landmark analyses at 13 weeks, OS was also longer for those with T cell Rsps (HR 6.5 (90% CI (2.1 to 29.2)) and for those with objective clinical responses. TME evaluation revealed increased densities of CD8+T cells, CD20+B cells, and Tbet+cells by day 22.ConclusionsTreatment with the 6MHP vaccine plus pembrolizumab was safe, increased intratumoral lymphocytes, and induced T cell Rsps associated with prolonged OS. The low T cell Rsp rate in PD-1 Ab-experienced participants corroborates prior murine studies that caution against delaying cancer vaccines until after PD-1 blockade. The promising objective response rate and OS in PD-1 Ab-naïve participants support consideration of a larger study in that setting.