bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unclasping potential chickpea resources for the antioxidant enzyme superoxide dismutase
Authors: Singh Amrendra Pratap , Singh Rajesh Kumar , Hegde Venkatraman S. , Shukla Narayani , Saini Pinki , Yadav Renu , Yadav Neelam , Aggarwal Ranjana , Kumar Rajendra 
Published: May 2022

AbstractBackgroundThe investigation was conducted to assess the diverseness and identify novel resources to be utilized in chickpea abiotic‐biotic stress resistance breeding for the antioxidant enzyme Superoxide Dismutase. The plants were grown in a randomized block design in triplicates under all suitable agronomic practices using PUSA 256 as a check. Fresh leaves were collected for the estimation of enzyme superoxide dismutase (SOD) and DNA extraction. Number of pods were recorded on 20 individual plants from the middle of the row for each of the 12 genotypes. Employing 32 Sequence Tagged Microsatellite Site (STMS) markers together with morpho‐biochemical data, Jaccard's similarity coefficients along with dendrograms were generated to compare and assess the diversity among the genotypes.ResultsAmong the 12 chickpea genotypes, poorest versus best performers were identified as BGD‐70 versus ICRISAT‐3668 for SOD activity. Out of 32 STMS primers, 80 alleles with 2.5 an average per loci were found. The marker TA‐80 with the highest polymorphic information content (PIC) could be identified to be used in molecular characterization. The meticulous perusal revealed that the genotypes ICRISAT‐3668 and SBD 377, distantly located on different molecular clusters, expressed the higher SOD activity with the observed distances indicating genetic governance, probably by a limited number of polygenes/OTLs and might be utilized as a potential source for the SOD activity for chickpea abiotic‐biotic stress resistance breeding programs.ConclusionThe identified novel genetic resources may be used to widen the germplasm base, prepare a maintainable catalog and identify systematic blueprints for future chickpea abiotic‐biotic stresses breeding strategies.
The Hannover Coupler V2: Audiological outcomes of a round window coupler for the Vibrant Soundbridge
Authors: Knölke Nicole , Murawski Dawid , Wardenga Nina , Busch Susan , Maier Hannes , Lenarz Thomas 
Published: May 2022

AbstractIntroductionThe Hannover Coupler version 2 (HC2) was designed to (1) adapt the coupler geometry to the round window (RW) niche (2) to stabilize the floating mass transducer, and (3) to control static coupling forces to the RW. First audiological outcomes with a custom‐made HC2 are reported here.Material and MethodsTen patients were enrolled in our site‐initiated, prospective study. To assess audiological outcomes up to 6 months, preoperative and postoperative hearing thresholds, word recognition score (WRS) at 65 dB SPL and the speech recognition threshold in quiet and noise were performed. The effective gain (EG) and the coupling efficiency were calculated.ResultsOne revision surgery had to be performed during the study period and a significant, but clinically not relevant bone conduction thresholds change was observed at 4 and 6 kHz at 6‐month follow‐up. At 6 months, the median WRS (n = 10) improved significantly from 0% to 80%. The median speech reception threshold in noise improved significantly from 11.6 to −2.4 dB SNR, and in quiet significantly from 79.6 to 44.4 dB SPL. The average EG of −1.3 dB indicated a closure of the air bone gap. The determined average coupling efficiency of 23.3 dB was within the acceptance range suggested by the manufacturer.ConclusionFor patients with mixed hearing loss and multiple ear surgeries, the HC2 provided good and stable speech recognition results exceeding published results of RW coupling without a coupler or coupling with the RW soft coupler.
High‐frequency pH time series reveals pronounced seasonality in Arctic coastal waters
Authors: Muth Arley F. , Kelley Amanda L. , Dunton Kenneth H. 
Published: May 2022

AbstractThe accelerated rate of climate change in the Arctic Ocean occurs in conjunction with a system known for its extreme seasonal variability. Here, we present 2 years of continuous pH, salinity, and temperature data from the north Arctic coast of Alaska from instruments deployed in a kelp bed at 4.5–6 m depths in Stefansson Sound. At the innermost site, which receives freshwater runoff from the nearby Sagavanirktok River, short‐term pH variability in late spring and summer produced pH values up to 8.67. The pH values of the deeper offshore site were less affected by freshwater input, although biological (heterotrophy) and physiochemical (ice formation) processes dominated during the winter months, driving pH down to 7.47 during the 8‐month period of ice cover. These long‐term physicochemical measurements reveal the natural but critical influence of changing river inputs on the pH of Arctic nearshore waters which support highly productive communities and subsistence fisheries.
Meringue‐Inspired Fabrication of Highly Thermally Conductive BNNSs/SiCNWs/Epoxy Composites with Shape‐Programmable 3D Networks
Authors: Li Weizhen , Jin Xulong , Wang Shulong , Li Zongze , Gan Wenjun 
Published: May 2022

AbstractThe construction of effective heat transfer routines is becoming more important because of the fast development of modern electronics. However, traditional network templates with fixed size cannot meet the various demands on the shape of products. Herein, a facile construction of a shape‐programmable 3D thermal network for epoxy composites is provided from the inspiration of meringue. Driven by the synergistic effect of silicon carbide nanowires (SiCNWs) and boron nitride nanosheets (BNNSs), the thermal conductivity (TC) of BNNSs/SiCNWs/epoxy composites with a 3D network is successfully enhanced to 0.69 W m–1 K–1 at low filler content (2.78 wt%), 3.8 times in comparison with neat epoxy, and the η (TC efficiency of filler) reaches 101. Meanwhile, the mechanical and thermal properties of composites are also enhanced (E' from 2.47 GPa (epoxy) to ≈3.50 GPa, Tg from 123 to 137 °C at 2.78 wt% BNNSs/SiCNWs content). This method may offer a promising prospect for the application in thermal management fields.
Polymethyl Methacrylate (PMMA) Nanocomposites Containing Graphene Nanoplatelets Decorated with Nickel Nanoparticles for Electromagnetic Interference (EMI) Shielding and Thermal Management Applications
Authors: Pan Yang , Yang Bin , Jia Ning , Yang Yuqing , Wang Yang , Zhang Nuo , Xia Ru , Qian Jiasheng , Wang Siyu , Tu Youlei , Shi You , Fang Yirong 
Published: May 2022

AbstractHere, Ni@graphene nanoplatelet (GNP) nanohybrids are obtained via an interfacial reaction growth method and a series of poly(methyl methacrylate) (PMMA)/Ni@GNP composites are prepared by a solution mixing‐ultrasonic dispersion‐hot pressing technology. The influence of Ni@GNP on the electromagnetic interference (EMI) shielding, dielectric, and thermal management behaviors of the composites is intensively investigated. The microcapacitors formed using Ni@GNP as plates and PMMA as matrix significantly improve the dielectric properties of the composites. Enhancement on thermal conduction and EMI properties of PMMA composites with increasing Ni@GNP content can be ascribed to the unique structure of Ni@GNP and it is the filler interconnection network that renders the composite's desirable thermally conductive and thermomechanical properties. A facile way of fabricating polymeric composites with satisfactory thermal conductivity and high‐performance electromagnetic shielding is provided here. The obtained polymer composites display highly promising applications in the thermal management and EMI shielding of electronic devices.
Coacervation between Two Positively Charged Poly(ionic liquid)s
Authors: Zhang Chongrui , Cai Yinmin , Zhao Qiang 
Published: May 2022

AbstractComplex coacervates are usually formed through electrostatic attraction between oppositely charged polyelectrolytes, with a few exceptions such as coacervates of like‐charge proteins and polyelectrolytes, both in vivo and in vitro. Understanding of the preparation and mechanisms of these coacervates is limited. Here, a positively charged poly(ionic liquid), poly(1‐vinyl‐3‐benzylimidazolium chloride) (PILben), is designed that bears benzene rings in repeating units. Fluidic coacervates are prepared by mixing the PILben aqueous solution with a like‐charge poly(ionic liquid) named poly(dimethyl diallyl ammonium chloride) (PDDA). The effects of polymer concentration, temperature, and ionic strength in the PILben‐PDDA coacervate are studied. Raman spectroscopy and 2D 1H‐13C heteronuclear single quantum coherence (1H‐13C HSQC) characterizations verify that the coacervate formation benefits from the cation‐π interaction between PILben and PDDA. This work provides principles and understandings of designing coacervates derived from like‐charge poly(ionic liquids) with high charge density.
Battling extraordinary situations and conflicting emotions—A qualitative study of being a newly graduated Registered Nurse in the emergency department during the COVID‐19 pandemic
Authors: Carnesten Hillewi , Wiklund Gustin Lena , Skoglund Karin , Von Heideken Wågert Petra 
Published: May 2022

AbstractAimTo describe newly graduated registered nurses’ (NGRNs’) experiences of encountering stress in emergency departments (EDs) during the COVID‐19 pandemic.DesignA qualitative descriptive study.MethodsData from 14 in‐depth interviews with NGRNs working in an ED for 3‐36 months after graduation was analysed by the means of qualitative content analysis as described by Graneheim and Lundman. Interviews were conducted from March to November 2020 covering the first two waves of the pandemic.ResultsData revealed three categories and nine subcategories comprised in the theme Battling extraordinary situations and conflicting emotions. Empowered by acknowledging themselves as important caregivers during the pandemic NGRNs struggle against limitations and exert themselves beyond their known limit. External stressors due to work overload in combination with understaffing force NGRNs into the role of the experienced nurse prematurely and internal stressors derives from part taking in less qualitative care.
A comparative study of patient safety in the intensive care units
Authors: Atashzadeh‐Shoorideh Foroozan , Shirinabadi Farahani Azam , Pishgooie Amir Hosein , Babaie Mohadese , Hadi Nazanin , Beheshti Maryam , Zadeh Ensieh Fathollah , Skerrett Victoria 
Published: May 2022

AbstractAimThis study aimed to assess patient‐safety principles in ICUs.DesignThis is a descriptive‐comparative study.MethodsThe research environment includes ICUs of hospitals affiliated to the two universities of medical sciences in Tehran. Sampling was done by census using Time and Event Sampling methods. Research instrument was “Patient Safety Principles Checklist”. Data analysis was performed using SPSS‐20 and descriptive‐inferential statistics with a significance level of 0.05.ResultsThere is no significant difference (p‐value = .15) in the level of observance of patient‐safety principles in two university‐affiliated hospitals A (133.26 ± 9.14) and B (128.16 ± 18.01). Evaluation of the mean scores obtained in each dimension and in each of the ICUs was showed that only in dimension No.3 the difference was significant (F[68,2] = 5.20, p‐value = .008) and in the AICUs (16.13 ± 1.8) (p‐value = .04), it was significantly lower than other ICUs. Identifying risk factors for the patient’s immunity reduces the side effects of patient care.
Mechanical, wear and fatigue behavior of silane‐treated corncob biosilica toughened epoxy resin composite reinforced with prickly pear short fibers
Authors: Sathish Kumar S. , Manimaran R. , Anbukarasi K. 
Published: May 2022

AbstractThis research focused on investigating the mechanical, wear, and fatigue behavior of an epoxy composite toughened with corncob biosilica (CCB) and prickly pear fiber (PPF). The primary aim of this research was to improve the load bearing effect of high‐brittle matrix by adding eco‐friendly fiber and particle. The surface treatment on the fiber and particle was done using an amino silane, 3‐Aminopropyltrimethoxysilane (APTMS). The natural fiber composites are prepared by hand layup process and characterized in accordance with ASTM standards. The experimental results indicated that the addition of fiber and particles increased the tensile and flexural strength up to 61% and 50%, respectively. Similarly, it is noted that the biosilica particles improved the bonding and reduced the rate of wear of composites, as well as lowered the stress intensity factor. A lowest wear rate of 0.037 and COF of 0.38 were noted for EFC2 composite designation. The morphological study of the fractured composites revealed improved fiber adhesion to the matrix. This reduced intensity of stress, increased wear resistance and higher fatigue life ensures the composite's application in structural and industrial applications.
Effects of halloysite clay nanotubes on the energy absorption and failure mechanisms of glass/epoxy composite tubes subjected to quasi‐static axial crushing
Authors: Alshahrani Hassan , Sebaey Tamer A. , Hegazy Dalia A. , Abd El‐baky Marwa A. 
Published: May 2022

AbstractThe capability of a structure to absorb enormous amount of energy is a crucial issue, particularly for structural components of vehicles, in decreasing the injury in case of collision. The current study investigates the impact of the presence of halloysite clay nanotubes (HNTs) on crashworthiness performance of glass/epoxy energy absorbent composite tubes. Specimens filled with 0, 1, 2, 3, and 4 wt% of HNTs were manufactured via wet‐wrapping process and tested under quasi‐static axial crushing. The crush load–displacement response, initial crushing load , average crushing load (), crushing force efficiency (CFE), absorbed energy (U), specific absorbed energy (SEA) for the proposed composite tubes were determined and discussed. The crushing behaviors for all specimens were traced. Results indicated that the specimens' failure mechanisms and the energy absorption capacities of nanofilled glass reinforced epoxy composites are controlled by wt% of HNTs. The presence of HNTs improves the energy absorbing capacities of glass/epoxy composites during the crushing process. Composite tubes filled with 4 wt% of HNTs are recommended as energy dissipating elements in vehicles. Weibull distribution was applied to show the failure probabilities and the scatter in the output data. The obtained failure probability graphs are important tools for helping the designers to understand and chose the suitable material for the required design.
Synthesis and biological evaluation of cilengitide derivatives on TGF‐β1‐induced epithelial‐to‐mesenchymal transition in human non‐small cell lung cancer cells
Authors: Park Kyeong‐Yong , Jeong Jisu , Kim Jiyeon 
Published: May 2022

AbstractEpithelial‐to‐mesenchymal transition (EMT) is an important process leading to invasiveness of cancer cells and poor prognosis in non‐small cell lung cancer (NSCLC) progression. Cilengitide (cyclo[RGDf(NMe)V]), a cyclic RGD pentapeptide, has been shown to enhance the inhibitory effect of epidermal growth factor receptor (EGFR) inhibitors on TGF‐β1‐induced mesenchymal marker expression and invasion by NSCLC A549 cells. In this study, we synthesized cilengitide and derivatives and evaluated their biological effects on TGF‐β1‐induced EMT phenotype marker expression and invasion in human NSCLC cells. Among the synthesized derivatives, R‐1 (cRGDwV) and R‐7 (cRGDyV) were found to be the most effective in inhibiting the growth of NSCLC cells. These cilengitide derivatives showed an inhibitory effect on the TGF‐β1‐induced EMT process and invasion through inhibition of Smad or non‐Smad signaling pathways in NSCLC A549 cells. Through this study, we demonstrated that cilengitide derivatives containing the RGD sequence and hydrophobic amino acids, such as cilengitide, exhibit inhibitory effects on NSCLC cell growth and EMT inhibition. In addition, the potential of these peptides as a drug that can be used to inhibit metastasis of various cancers accompanying the EMT process was suggested.
A new soft red winter wheat cultivar ‘GA 08535‐15LE29’ adapted to Georgia and the U.S. southeast region
Authors: Mergoum Mohamed , Johnson Jerry , Buck James , Buntin G. David , Sutton Steve , Lopez Benjamin , Mailhot Daniel , Chen Zhenbang , Bland Dan , Harrison Stephen , Murphy Joseph Paul , Mason Esten , Sutton Russell Lane , Babar Ali , Brown‐Guedira Gina , Ibrahim Amir , Boyles Richard E. , Baik Byung‐Kee , Marshall David , Griffey Carl Allen , Cambron Sue Ellen , Chen Xianming , Cowger Christina 
Published: May 2022

AbstractSoft red winter wheat (SRWW) (Triticum aestivum L.) production in the southeastern United States is affected by biotic and abiotic stresses that can result in yield losses and reduced acreage. Developing new cultivars with high yield, good resistance to predominant pests, and acceptable quality to maximize value in regional markets is needed. The University of Georgia (UGA) SRWW breeding program, in collaboration with institutions in the region including the Southern UNiversities GRAINS (SUNGRAINS) programs, is responding to these challenges by developing and releasing superior cultivars adapted to the region. ‘GA 08535‐15LE29’ (Reg. no. CV‐1191, PI 693269) SRWW cultivar was developed and released by the UGA College of Agricultural and Environmental Sciences and licensed to Uni South Genetics seed company in 2018 as USG 3640. GA 08535‐15LE29 is well adapted to Georgia and the U.S. southeast region with high yield and good resistance to leaf (Puccinia triticina Erikss.) and stripe (P. striiformis Westend.) rusts, Fusarium head blight (caused by Fusarium graminearum Schwabe), powdery mildew (Erisyphe graminis), and Soil‐borne wheat mosaic virus (SBWMV) diseases. GA 08535‐15LE29 showed moderate field resistance to Hessian fly [Mayetiola destructor (Say)]. GA 08535‐15LE29 has Sbm1 and Yr17/Lr37/Sr38 for resistance to SBWMV and rust diseases and has good grain volume weight and acceptable milling and baking qualities.
Adherence rate, barriers to attend, safety and overall experience of a physical exercise program via telemonitoring during COVID‐19 pandemic for individuals with Parkinson's disease: A feasibility study
Authors: Torriani‐Pasin Camila , Domingues Vitoria Leite , de Freitas Tatiana Beline , Silva Thaina Alves da , Caldeira Marcelo Figueiredo , Júnior Ricardo Pereira Alcantaro , Lara Audrea Regina Ferro , Antonio Beatriz de Araujo , Palma Gisele Carla dos Santos , Makhoul Marina Portugal , Mochizuki Luis 
Published: May 2022

AbstractBackgroundTelemonitoring can maintain daily exercise routine during the COVID‐19 pandemic of individuals with Parkinson's disease (PD). However, there are barriers to adherence and attendance with remote physical rehabilitation. The main objective of this study was to evaluate adherence rate, barriers to attendance, and safety of a telemonitoring program for individuals with PD; and secondarily to evaluate the individual and their family members perceived overall experience when performing the telemonitoring physical exercise program.MethodsThis was a phase 1 of a clinical trial, engaging 19 individuals with idiopathic PD of an in‐person community rehabilitation program. For 24 weeks an asynchronous telemonitoring physical exercise program delivered two sessions per week by video including warm‐up, balance, aerobic and resistance exercises, and cool‐down. During the remote program were verified: adherence rate at entrance, attendance rate, barriers to attend, safety, and overall experience of the program.Results and conclusionOnly one participant did not perform any session and 18 participants completed between 2 and 34 sessions. Participants with a caregiver showed higher attendance rates. The most frequently cited barriers to attend the program were: pain; lack of motor skills; and reduced physical fitness. In relation to safety of the program, the most frequently reported was fear of falling. Although participants reported the telemonitoring program induced health benefits and they had positive experiences for themselves and for their families, most of participants prefer an in‐person program. In this sense, the asynchronous telemonitoring physical exercise program was safe, showed moderate adherence, with attendance rate depending on the presence of a companion.
Engineering defensin α‐helix to produce high‐affinitySARS‐CoV‐2 spike protein binding ligands
Authors: Fernandes Leonardo Antônio , Gomes Anderson Albino , Guimarães Beatriz Gomes , de Lourdes Borba Magalhães Maria , Ray Partha , da Silva Gustavo Felippe 
Published: May 2022

AbstractThe binding of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein to the angiotensin‐converting enzyme 2 (ACE2) receptor expressed on the host cells is a critical initial step for viral infection. This interaction is blocked through competitive inhibition by soluble ACE2 protein. Therefore, developing high‐affinity and cost‐effective ACE2 mimetic ligands that disrupt this protein–protein interaction is a promising strategy for viral diagnostics and therapy. We employed human and plant defensins, a class of small (2–5 kDa) and highly stable proteins containing solvent‐exposed alpha‐helix, conformationally constrained by two disulfide bonds. Therefore, we engineered the amino acid residues on the constrained alpha‐helix of defensins to mimic the critical residues on the ACE2 helix 1 that interact with the SARS‐CoV‐2 spike protein. The engineered proteins (h‐deface2, p‐deface2, and p‐deface2‐MUT) were soluble and purified to homogeneity with a high yield from a bacterial expression system. The proteins demonstrated exceptional thermostability (Tm 70.7°C), high‐affinity binding to the spike protein with apparentKdvalues of 54.4 ± 11.3, 33.5 ± 8.2, and 14.4 ± 3.5 nM for h‐deface2, p‐deface2, and p‐deface2‐MUT, respectively, and were used in a diagnostic assay that detected SARS‐CoV‐2 neutralizing antibodies. This work addresses the challenge of developing helical ACE2 mimetics by demonstrating that defensins provide promising scaffolds to engineer alpha‐helices in a constrained form for designing of high‐affinity ligands.