bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapie maligner Lymphome
Authors: Hentrich Marcus 
Published: June 2022

ZUSAMMENFASSUNG
Ziel Ziel dieses Artikels ist es, einen aktuellen Überblick
über gegenwärtige Standards und aktuelle Entwicklungen in der
Therapie maligner Lymphome zu geben.
Material und Methoden Nicht-systematische Übersicht über
die Therapie wichtiger Lymphom-Entitäten unter Berücksichtigung
aktueller Leitlinien.
Ergebnisse Patienten mit aggressiven B-Zell-Lymphomen sowie
Hodgkin-Lymphomen werden mit kurativem Therapieziel behandelt. Therapiestandard
des diffusen großzelligen B-Zell-Lymphoms sind 6–8 Zyklen
R-CHOP. In Abhängigkeit vom internationalen Prognose-Index sind
Modifikationen dieser Therapie möglich. Im Falle eines frühen
Rezidivs wird der bisherige Standard einer Hochdosischemotherapie (HDCT) mit
autologer Stammzelltransplantation (ASCT) zukünftig durch eine Therapie
mit CAR-T-Zellen abgelöst werden. Eine Stadien-adaptierte Therapie des
Hodgkin-Lymphoms führt zu sehr hohen Heilungsraten, die auch in
fortgeschrittenen Stadien bei ca. 90% liegen. Jüngere Patienten
mit Rezidiv erhalten eine HDCT mit ASCT. Die Verfügbarkeit des
Antikörper-Wirkstoff-Konjugates Brentuximab Vedotin sowie der
Anti-PD1-Antikörper Nivolumab und Pembrolizumab haben die
Rezidivtherapie des Hodgkin-Lymphoms in den letzten Jahren erheblich bereichert.
Indolente Lymphome sind durch langsames Wachstum, längere stabile
Krankheitsphasen und meist lange Überlebenszeiten der Patienten
charakterisiert. Die Therapie des häufigsten Vertreters der indolenten
Lymphome, dem follikulären Lymphom, erfolgt mit einer Kombination aus
einem gegen CD20-gerichteten Antikörper und mit z. B. CHOP oder
Bendamustin, worunter lange progressionsfreie Zeiten erreicht werden.
Diskussion und Schlussfolgerung Die Therapie maligner Lymphome ist in
stetem Wandel. Der Einsatz verschiedener Immuntherapien habt in den letzten
Jahren zu einer Verbesserung der Therapieergebnisse geführt.
Ausgewählte Mikronährstoffe in der onkologischen
Intervention – ein Update
Authors: Gröber Uwe , Holzhauer Peter , Kisters Klaus 
Published: June 2022

ZusammenfassungJe nach Tumorentität und Geschlecht supplementieren bis zu 90%
der Krebspatienten antioxidative und immunrelevante Mikronährstoffe,
häufig ohne das Wissen des behandelnden Arztes. Die Gründe
für die Inanspruchnahme komplementärmedizinischer Therapien sind
vielfältig, sie sind meist in einem patienteneignen, salutogenetisch
orientierten Konzept zu Gesundung, Heilung und Bewältigung der
Krebserkrankung sowie zur onkologischen Therapie zu finden. Aus Sicht der
Patientinnen sind Aspekte mit hoher Priorität die Wahrung der Autonomie,
die Verwirklichung einer Selbstbeteiligung und die Optimierung der Resilienz in
einer kritischen, oft bedrohlichen Lebensphase, die es zu bewältigten
gilt. Komplementäre Maßnahmen werden sowohl in der Akuttherapie
als auch in der Nachsorge eingesetzt. Die Sicherheit und Kompatibilität
der vielfältigen komplementären Maßnahmen mit der
konventionellen Tumortherapie sind von größter Bedeutung.
Onkologisch tätige Ärzte sollten daher über die aktuelle
Bedeutung von Vitamin D, Selen, Omega-3-Fettsäuren und anderen
(Mikro)nährstoffen sowie potenziellen Interaktionen mit der
Krebstherapie informiert sein.
Physical and Technical Demands and Preparatory Strategies in Female
Field Collision Sports: A Scoping Review
Authors: Dane Kathryn , Simms Ciaran , Hendricks Sharief , West Stephen W. , Griffin Steffan , Nugent Frank J. , Farrell Garreth , Mockler David , Wilson Fiona 
Published: June 2022

AbstractWomen’s participation in field collision sports is growing worldwide.
Scoping reviews provide an overview of scientific literature in a developing
area to support practitioners, policy, and research priorities. Our aim is to
explore published research and synthesise information on the physical and
technical demands and preparation strategies of female field collision sports.
We searched four databases and identified relevant published studies. Data were
extracted to form (1) a numerical analysis and (2) thematic summary. Of 2318
records identified, 43 studies met the inclusion criteria. Physical demands were
the most highly investigated (n+=+24), followed by
technical demands (n+= 18), tactical considerations
(n+=+8) and preparatory strategies (n=1). The
key themes embody a holistic model contributing to both performance and injury
prevention outcomes in the context of female field collision sports. Findings
suggest a gender data gap across all themes and a low evidence base to inform
those preparing female athletes for match demands. Given the physical and
technical differences in match-demands the review findings do not support the
generalisation of male-derived training data to female athletes. To support key
stakeholders working within female field collision sports there is a need to
increase the visibility of female athletes in the literature.
Treatment and Bleeding Complications of Cancer-Associated Venous Thromboembolism: A Korean Population-Based Study
Authors: Kim Sang-A , Lee Ju Hyun , Lee Ji Yun , Hwang Hun-Gyu , Kim Yang-Ki , Yhim Ho-Young , Hong Junshik , Lee Jeong-Ok , Bang Soo-Mee 
Published: June 2022

Objectives This study investigated the treatment pattern and the rate of bleeding complications in real-world practice in cancer-associated venous thromboembolism (CT) patients.
Methods We used the Korean Health Insurance Review and Assessment Service database (2014–2018). Among patients with venous thromboembolism, patients with concomitant malignancy diagnostic codes were categorized as CT, while all others were categorized as non-CT. Treatments were categorized as direct oral anticoagulant (DOAC), parenteral anticoagulant (PAC), warfarin, and mixed anticoagulants.
Results We identified 27,205 CT and 57,711 non-CT patients. DOACs were the most frequently used anticoagulants. The proportion of patients treated with PAC was higher in CT than in non-CT patients (35.7 vs. 19.5%; p < 0.01). In CT, the cumulative incidence of any/major bleeding was higher with DOAC (8.1%/3.9%) than with PAC (7.5%/3.2%; p = 0.04 and 0.01, respectively). However, there was no difference in major bleeding when compared with warfarin (p = 0.11) or mixed anticoagulants (p = 0.94). Overall, gastrointestinal (GI) cancer patients showed higher risks of bleeding. The cumulative incidence of major GI bleeding was higher with DOAC than with PAC (4.9 vs. 3.0%; p < 0.01), while there was no difference compared with warfarin (p = 0.59) or mixed anticoagulants (p = 0.80). Major bleeding with each DOAC showed no difference among entire CT (p = 0.94), GI cancer (p = 0.27), and genitourinary cancer (p = 0.88) patients.
Conclusion Five years after their introduction into clinical practice, DOACs have become the most prescribed anticoagulant in Korea. In our patient population, bleeding complications occurred more frequently in CT than in non-CT, especially in patients treated with DOACs.
Identification of Nrf2 Activators from the Roots of Valeriana officinalis
Authors: Afzal Sualiha , Zhou Xian , Or King , Raju Ritesh , Münch Gerald 
Published: June 2022

AbstractVarious age-related chronic diseases have been linked to oxidative stress. The cellular antioxidant response pathway is regulated by the transcription factor nuclear erythroid factor 2.
Therefore, plant-derived nuclear erythroid factor 2 activators might be useful therapeutics to stimulate the bodyʼs defense mechanisms. Our study focused on the discovery of potent nuclear
erythroid factor 2 activators from medicinal plants. Initially, a variety of medicinal plant extracts were screened for nuclear erythroid factor 2 activity using a nuclear erythroid factor 2
luciferase reporter cell line. Among these, Valerian (Valeriana officinalis) root was identified as a potent candidate. Sequential extraction and bioassay-guided fractionation led to
the isolation of four nuclear erythroid factor 2-active compounds, which were structurally identified by NMR and LC/HRMS as the known compounds isovaltrate, valtrate, jatamanvaltrate-P, and
valerenic acid. These four compounds were then tested in relevant biological assays. Firstly, their effects on the expression of glutathione S-transferase, glutamate–cysteine ligase
catalytic subunit, glutathione peroxidase, and heme oxygenase 1 were determined in HepG2 cells. Glutathione S-transferase P1 and glutamate–cysteine ligase catalytic subunit were upregulated
by isovaltrate, valtrate, and jatamanvaltrate-P, while heme oxygenase 1 was upregulated by isovaltrate, jatamanvaltrate-P, and valerenic acid. The four compounds also increased the levels of
glutathione and its metabolite, CysGly. As glutathione aids in the detoxification of hydrogen peroxide, cytoprotective effects of these four nuclear erythroid factor 2 activators against
hydrogen peroxide toxicity were investigated, and indeed, the compounds significantly improved cell survival. This study provides evidence that four valepotriates from the roots of
V. officinalis are activators of nuclear erythroid factor 2-mediated antioxidant and detoxification pathways. Our data might expand the medical use of this plant beyond its current
application as a sleep aid.
The Curing Coma Campaign and the Future of Coma Research
Authors: Olson DaiWai M. , Hemphill J Claude , Provencio J Javier , Vespa Paul , Mainali Shraddha , Polizzotto Len , Kim Keri S. , McNett Molly , Ziai Wendy , Suarez Jose I. ,   the Curing Coma Campaign Collaborators
Published: June 2022

AbstractRecovery from coma or disordered consciousness is a central issue in patients with acute brain injuries such as stroke, trauma, cardiac arrest, and brain infections. Yet, major gaps remain in the scientific underpinnings of coma and this has led to inaccuracy in prognostication and limited interventions for coma recovery. Even so, recent studies have begun to elucidate mechanisms of consciousness early and prolonged after acute brain injury and some pilot interventions have begun to be tested. The importance and scope of this led in 2019 to the development of the Curing Coma Campaign, an initiative of the Neurocritical Care Society designed to provide a platform for scientific collaboration across the patient care continuum and to empower a community for purposes of research, education, implementation science, and advocacy. Seen as a “grand challenge,” the Curing Coma Campaign has developed an infrastructure of scientific working groups and operational modules, along with a 10-year roadmap.
Functional Muscle Transfer after Oncologic Extremity Resection
Authors: Hassan Abbas M. , Tesfaye Eliora A. , Rashiwala Abhi , Roubaud Margaret J. , Mericli Alexander F. 
Published: June 2022

Abstract
Background Functional muscle transfer (FMT) can provide wound closure and restore adequate muscle function for patients with oncologic extremity defects. Herein we describe our institutional experience with FMT after oncological resection and provide a systematic review and meta-analysis of the available literature on this uncommon procedure.
Methods A single-institution retrospective review was performed, including all patients who received FMT after oncological resection from 2005 to 2021. For the systematic review and meta-analysis, PubMed, Cochrane, Medline, and Embase libraries were queried according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines; results were pooled, weighted by study size, and analyzed.
Results The meta-analysis consisted of seven studies with 70 patients overall, demonstrating a mean Medical Research Council (MRC) score of 3.78 (95% confidence interval: 2.97–4.56; p < 0.01). The systematic review included 28 studies with 103 patients. Receipt of adjuvant chemotherapy was associated with significantly lower mean MRC score (3.00 ± 1.35 vs. 3.90 ± 1.36; p = 0.019). Seventy-four percent of the patients underwent free FMT, with the most common donor muscle being the latissimus dorsi (55%). The flap loss rate was 0.8%. Neoadjuvant chemotherapy (p = 0.03), radiotherapy (p = 0.05), pedicled FMTs (p = 0.01), and a recipient femoral nerve (p = 0.02) were associated with significantly higher complication rates. The institutional retrospective review identified 13 patients who underwent FMT after oncological resection with a median follow-up time of 21 months (range: 6–74 months). The most common tumor necessitating FMT was undifferentiated pleomorphic sarcoma (77%), and the most common donor muscle was the latissimus dorsi (62%). A high body mass index was associated with prolonged neuromuscular recovery (R = 0.87, p = 0.002).
Conclusion FMT after oncological resection may contribute to improved extremity function. Careful consideration of risk factors and preoperative planning is imperative for successful FMT outcomes.
Quad Fever in a Case of Cervical Cord Injury—A Rare Case Report
Authors: Ali Sheena , Ganesan Duraisamy , Sundaramoorthy Varun 
Published: June 2022

AbstractBy definition, “quad fever” is an extreme elevation in body core temperature beyond 40.8°C (105.4°F) in a patient with spinal cord injury. This type of central nervous system hyperpyrexia is seen in spinal cord injury patients, particularly those with high cervical spine injury with quadriplegia. However, it has also been described in paraplegics with a mid- or higher level thoracic spine injury. The incidence of “quad fever” is rare, with the highest reported temperature being 44°C (111.2°F) with chronicled fatal outcomes.Though the use of antipyretics is generally efficacious, they are considerably ineffective in treating the hyperpyrexia seen in this type of severe central autonomic thermodysregulation.Here, we present a case of high cervical spine injury in a 24-year-old male. The trauma resulted in a C3–5 level cord contusion with incomplete quadriplegia (ASIA [American Spinal Cord Injury Association Impairment Scale] grade B). The patient developed high grade fever of 106°F within a week of admission postoperatively.Pancultures were negative and the wound was clean. Despite treatment with higher antibiotics and an infection disease specialist's consult, no obvious etiology was found. Drug-induced fever and thyroid function tests were excluded in other less-common causes.Based on the diagnosis of exclusion, “quad fever” was inferred as the cause. He had other signs of autonomic instability during the episodes such as bradycardia with hypotension.Our patient showed an almost early response to treatment to betablockers and antipsychotics after failure to respond to antibiotics, mechanical hypothermia, and antipyretics.
Fibrin Sealants Do Not Reduce the Rate of Seroma Formation in Postmastectomy Breast Reconstruction: A Systematic Review and Meta-analysis
Authors: Massada Karen E. M. , Wu Meagan , Webster Theresa K. , Panichella Juliet , Coronado Michael C. , Talemal Lindsay , Elmer Nicholas , Araya Sthefano , Brebion Rohan , Baltodano Pablo A. , Patel Sameer A. 
Published: June 2022

Abstract
Background Breast reconstruction using deep inferior epigastric perforator (DIEP) and latissimus dorsi (LD) flaps following mastectomy are associated with seroma formation, most commonly at the donor site. We sought to perform an updated systematic review and meta-analysis on the effects of fibrin sealant on donor-site complications following DIEP and LD flap breast reconstruction.
Methods A comprehensive literature search was conducted (March 2021) in PubMed, OVID, and Cochrane databases. Articles analyzing the efficacy of fibrin glue in reducing donor-site morbidity in DIEP and LD breast reconstruction were included. The outcomes assessed were seroma formation and duration of drainage.
Results A total of 17,265 articles were screened, and 9 articles were selected for analysis, which comprised 632 surgical sites in 611 patients. Comparing fibrin glue and quilting to quilting alone showed no significant difference in seroma formation (pooled risk ratio [RR]: 0.51; 95% confidence interval [CI]: 0.12, 2.25). Similarly, comparing fibrin glue alone to no fibrin glue showed no significant difference in seroma formation (pooled RR: 1.03; 95% CI: 0.66, 1.61) or duration of drain (pooled RR: −0.85; 95% CI: −4.09, 2.40); there was however a difference in duration of drain in those who received fibrin glue and quilting versus quilting alone (pooled RR: −2.13; 95% CI: −3.27, −0.99).
Conclusion The existing literature supports that the use of fibrin glue is not associated with a decrease in seroma formation in DIEP and LD flaps and is weakly associated with a reduction in the drainage duration only if used in conjunction with quilting.
Comparative Evaluation of Coronally Advanced Flap Procedure in Conjunction with Amniotic Membrane Versus Coronally Advanced Flap with Platelet-Rich Fibrin Membrane in Patients with Miller's Class I and II Gingival Recession Defects
Authors: Lamba Samiksha , Dahiya Ritu , Blaggana Anshu , Kaur Pawandeep , Gulia Krishan , Phogat Anjila , Sharma Jaya 
Published: June 2022

Abstract
Introduction Amnion membrane (AM) and platelet-rich fibrin (PRF) have been used as Guided Tissue Regeneration (GTR)-based root coverage procedures in treatment of gingival recession. The objective of the present study was to comparatively evaluate the coronally advanced flap (CAF) procedure in conjunction with AM versus CAF with PRF in patients with Miller's class I and II gingival recession defects (GRD).
Materials and Methods The sample size (Miller's Class I and Class II GRD) consisted of 24 patients who were stratified into two groups randomly (12 for each group). Group A patients were treated by CAF with PRF and Group B patients were treated by CAF with AM. Clinical parameters comprising plaque index (PI), gingival index (GI), pocket probing depth (PPD), clinical attachment level (CAL), and GRD were assessed at baseline, 3 months, and 6 months postoperatively.
Results The percentage of root coverage obtained in the study groups was 62% and 77%, respectively, for Groups A and B. Statistically significant difference was obtained in the clinical parameters (PPD, CAL, and GRD) of Group B, which was treated by CAF with AM.
Conclusion Significant difference was found between Group A (CAF+ PRF) and Group B (CAF+ AM) membrane treated sites in reduction of PPD, gain in clinical attachment level, reduction of GRD from baseline to 3 months and baseline to 6 months, with more significant results seen with Group B.
Intraoperative Imaging Improves Posterolateral THA Accuracy with Increased Time Cost
Authors: Ralston William M. , Aggarwal Ajay , Keeney James A. 
Published: June 2022

AbstractIntraoperative imaging may improve total hip arthroplasty (THA) component placement, but the time and cost associated with this approach have not been well described. We assessed component placement accuracy, operative time, and operating room (OR) charges for 270 patients undergoing posterolateral THA (PL-THA) with or without intraoperative imaging. This study retrospectively compared 135 PL-THA performed with intraoperative digital radiography (group PLxr) and a contemporary cohort of 135 PL-THA performed without imaging (group PL). Postoperative radiographs were evaluated to determine outlier rates for acetabular inclination of 55 degrees or higher, anteversion less than 15 or more than 40 degrees, and leg length or offset differences more than 10 mm. Surgical procedure time was extracted from hospital OR records, and procedural costs were estimated from facility charges associated with 30-minute OR time blocks and intraoperative imaging. Group PLxr had significantly fewer outliers for acetabular inclination more than 50 degrees (5.2 vs. 21.5%, p < 0.001), acetabular inclination of 55 degrees or higher (0.7 vs. 8.1%, p = 0.01), acetabular anteversion less than 15 or more than 40 degrees (14.8 vs. 28.9%, p < 0.01), leg length difference more than 10 mm (2.2 vs. 10.4%, p = 0.01), and femoral offset difference more than 10 mm (1.5 vs. 9.6%, p < 0.01). The difference in component inclination less than 30 degrees was not significant (0.0 vs. 2.2%, p = 0.24). Intraoperative component adjustment occurred in 26 cases (21.5%), was associated with a 19-minute mean increase in operative time (p < 0.001) and $1,504 mean increase in facility charges compared with nonimaged cases. Imaged cases without component adjustment increased mean operative time by 9.4 minutes (p < 0.001) and mean operative charges by $766. Intraoperative imaging improves component placement accuracy during PL-THA and significantly reduces component placement outliers, particularly with respect to acetabular component inclination, femoral length, and femoral offset.
Level of Evidence Level III, case-control study.
Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report
Authors: Kumar Kishore S. , Naleer Mohamed H. , Visweswaran Vivek , Krishnamurthy Ganesh 
Published: June 2022

AbstractMelanotic neuroectodermal tumor of infancy (MNTI) is a rare, pigmented tumor. It is a locally aggressive neoplasm of neural crest origin with a high recurrence rate. It occurs in craniofacial sites in more than 90% of cases and most commonly in the maxilla. It may also occur in epididymis, testis, ovaries, soft tissue, and bones of the extremities. It occurs in infants younger than 1 year of age with a slight male preponderance. We report a rare case of a child presenting with midline frontal pigmented MNTI.
Clinical Decision Support for Fall Prevention: Defining End-User Needs
Authors: Rice Hannah , Garabedian Pamela M. , Shear Kristen , Bjarnadottir Ragnhildur I. , Burns Zoe , Latham Nancy K. , Schentrup Denise , Lucero Robert J. , Dykes Patricia C. 
Published: June 2022

Abstract
Background and Significance Falls in community-dwelling older adults are common, and there is a lack of clinical decision support (CDS) to provide health care providers with effective, individualized fall prevention recommendations.
Objectives The goal of this research is to identify end-user (primary care staff and patients) needs through a human-centered design process for a tool that will generate CDS to protect older adults from falls and injuries.
Methods Primary care staff (primary care providers, care coordinator nurses, licensed practical nurses, and medical assistants) and community-dwelling patients aged 60 years or older associated with Brigham & Women's Hospital-affiliated primary care clinics and the University of Florida Health Archer Family Health Care primary care clinic were eligible to participate in this study. Through semi-structured and exploratory interviews with participants, our team identified end-user needs through content analysis.
Results User needs for primary care staff (n = 24) and patients (n = 18) were categorized under the following themes: workload burden; systematic communication; in-person assessment of patient condition; personal support networks; motivational tools; patient understanding of fall risk; individualized resources; and evidence-based safe exercises and expert guidance. While some of these themes are specific to either primary care staff or patients, several address needs expressed by both groups of end-users.
Conclusion Our findings suggest that there are many care gaps in fall prevention management in primary care and that personalized, actionable, and evidence-based CDS has the potential to address some of these gaps.