bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vision-related quality of life after surgery for vitreoretinal disorders: an observational study
Authors: Márquez-Vergara Ilse Sarahí , Ríos-Nequis Geovanni Jassiel , Pita-Ortíz Ingrid Yazmín , Pérez-Cano Héctor Javier , Somilleda-Ventura Selma Alin 
Published: June 2022

Abstract
Background: Visual-related quality of life is not always included as a variable of surgical success. However, some questionnaires such as the Visual Function Quality-25 in the Spanish version have proven their reliability and validity, but the quality of life in patients undergoing surgery has not been explored in the Mexican population; so, this study aims to identify it in patients with the most prevalent vitreoretinal diseases.Methods: The Visual Function Quality-25 questionnaire was applied to 76 patients with advanced diabetic retinopathy, rhegmatogenous retinal detachment, and other causes of vitrectomy, pre-and postoperative. It was divided into 10-domains and interpreted according to the National Eye Institute scores, where the highest value was the best visual function. Student's t-test for related samples and Wilcoxon's t-test were used to compare each domain between measurements, and Pearson´s R test to correlate age and quality of life total score; a p-value <0.05 was considered significant.Results: Diabetic retinopathy patients showed an improvement after surgery in all domains, one and three months after surgery; the higher scores were in those who used air o gas as tamponade. In patients with rhegmatogenous retinal detachment, there was an improvement in almost all the items from the first month, with a higher difference observed up to three months, while a decrease in ocular pain was observed in other causes of vitrectomy. Differences found in all the quality-of-life scores at one versus three months were not statistical, but clinically significant.Conclusions: The study shows that visual-related quality of life domains improve after vitrectomy, predominately in diabetic retinopathy subjects; inclusion of this analysis might be considered relevant within the parameters of surgical success of the most prevalent vitreoretinal diseases.
Evaluation of olive mill wastewater membrane treatment to obtain a final retentate rich in hydroxytyrosol
Authors: Niknam Seyed Mehdi , Kashaninejad Mansoore , Benito José Manuel , Escudero Isabel 
Published: June 2022

Abstract
Olive mill wastewater (OMWW) is an extremely polluting dark liquid generated in large quantities during the extraction of olive oil. OMWW is also an interesting source of high-added value natural compounds such as biophenols, especially hydroxytyrosol (HT), a powerful antioxidant with proven nutritional and pharmaceutical properties. The main objective of this work was to explore the use of membrane technology for the treatment of OMWW in order to obtain a retentate stream rich in hydroxytyrosol and a permeate with low chemical oxygen demand (COD). Pretreatment was firstly performed by a combined centrifugation and acidification process. Then, several membrane operations were tested and phenolics rejection, HT content, COD removal and membrane fouling were examined. Best results were obtained using a single ultrafiltration process with a 10 kDa ST polyethersulfone membrane at 8 bar. Improved results were reached using a two-stage integrated system with 100 kDa US100 ultrafiltration and 200 Da NF90 nanofiltration membranes, at 5 and 10 bar, respectively. Volume reduction factor of 1.9 in ultrafiltration and 1.6 in nanofiltration yielded to 234.49 ± 26.08 mg/L of HT in the retentate (9-fold the HT content in the raw OMWW) and 94.15% COD removal.
Cardiac Papillary Fibroelastoma: Pulmonic Valve Involvement with Pulmonary Embolism and Pulmonary Hypertension
Authors: Jilani Danish , Ali Meher Binte , Abuzahra Mohammed 
Published: June 2022

Abstract
Pulmonic valve papillary fibroelastomas are rarely seen tumors of the cardiac valves. In this case, a pulmonic valve mass was seen on echocardiogram, which was diagnosed as papillary fibroelastoma due to characteristic imaging findings. Complications of pulmonary embolism and pulmonary hypertension were present. Due to contraindications, the patient was managed with anticoagulation instead of surgery.
Record-High Gain and Detectivity in Unipolar Barrier Solar Blind Avalanche Photodetector via Deliberate Lattice and Band Engineering
Authors: Zhang Qingyi , Li Ning , Zhang Tao , Dong Dianmeng , Yang Yongtao , Wang Yuehui , Dong Zhengang , Shen Jiaying , Zhou Tianhong , Liang Yuanlin , Tang Weihua , Zhang Yang , Wu Zhenping , Hao Jianhua 
Published: June 2022

Abstract
Ga2O3-based solar blind avalanche photodetectors (APDs) allow low voltage operation, optical filter-free and monolithic integration of PD arrays, and therefore they are promising to be alternative to the bulky and fragile photomultiplier tube (PMT) in weak deep-ultraviolet signal detection. However, so far the performances of all reported Ga2O3-based APDs are still inferior to PMTs due to restricted breakdown electric field and monolithic integration limitations. Here, by deliberate lattice and band engineering, we construct an n-Barrier-n (nBn) unipolar barrier APD consisting of β-Ga2O3/MgO/Nb:STO heterostructure, in which the enlarged conduction band offsets fortify the reverse breakdown and suppress the dark current while the negligible valance band offsets faciliate minority carrier flow. The lattice and band engineered unipolar barrier configuration provides deterministic control over the charge carriers flow and related avalanche multiplication effects. The developed unipolar barrier APDs exhibit record-high avalanche gain up to 5.86 × 105 and detectivity of 3.28 × 1017 Jones among the wafer-scale grown Ga2O3-based PDs, which are even comparable with commercial PMTs. These findings provide new insights into precise control of band alignment in APDs, which also offer great opportunities for high-performance Ga2O3-based electronics and optoelectronics.
Development and Analysis of Cereal Bar Based on Passion Fruit Shell Flour
Authors: Santos Isaú de Souza , Barros Vinicius Costa , Hunaldo Virlane Kelly Lima , Santos Leonardo Hunaldo dos , de Freitas Adriana Crispim 
Published: June 2022

Abstract
Brazil produces, daily, tons of solid organic waste resulting from the food industry, which compromise the ecosystem, since they are highly polluting materials. A large part of this waste is generated by juice extracting industries, which, when processing fruits, discard husks, albedos, seeds, shavings and vesicles. Passion fruit suffers a lot of loss during processing, as only 30% of the entire weight of the fruit is used, which is the pulp used to extract the juice. In recent years, the search for the use of these residues in the development of products with greater added value, such as flour with a high fiber content, has been the subject of research. The present work had as objective the physical, chemical and microbiological evaluation of the cereal bar formulated with passion fruit peel flour. Then, the cereal bar was subjected to microbiological and physical chemical analysis, showing absence of Staphylococcus aureus, Salmonella and Coliforms. The pH, moisture, water activity, titratable acidity, ash and brix degree were analyzed. At the end of the analysis, it was concluded that the use of passion fruit peel in the production of the cereal bar proved to be viable.
Tumor extracellular vesicles mediate anti-PD-L1-therapy resistance by decoying anti-PD-L1
Authors: Cai Zhijian , Chen Jiming , Yang Jie , Wang Wenhui , Guo Danfeng , Zhang Chengyan , Wang Shibo , Lu Xinliang , Huang Xiaofang , Wang Pingli , Zhang Gensheng , Zhang Jing , Wang Jianli 
Published: June 2022

Abstract
PD-L1+ tumor-derived extracellular vesicles (TEVs) cause systemic immunosuppression and possibly resist to anti-PD-L1 antibody (αPD-L1) blockade. However, whether and how PD-L1+ TEVs mediate αPD-L1-therapy resistance is unknown. Here, we show that PD-L1+ TEVs massively decoy αPD-L1 and that TEV-bound αPD-L1 is more rapidly cleared by macrophages, causing insufficient blockade of tumor PD-L1 and subsequent αPD-L1-therapy resistance. Either an increased dose of αPD-L1 or macrophage depletion mediated by clinical drug Pexidartinib abolishes αPD-L1-therapy resistance. In the treatment cycle with the same total treatment dose of αPD-L1, high-dose and low-frequency treatment has better antitumor effects than low-dose and high-frequency treatment, induces stronger antitumor immune memory, and eliminates αPD-L1-therapy resistance. Furthermore, increased doses of αPD-L1 and αPD-1 have comparable antitumor effects, but αPD-L1 amplify fewer PD-1+ Treg cells that are responsible for tumor hyperprogression. Altogether, our results reveal a TEV-mediated mechanism of αPD-L1-specific therapy resistance, thus providing promising strategies to improve αPD-L1 efficacy.
A machine learning approach for unbiased diagnosis of acute coronary syndrome in the emergency department
Authors: Zeng Cecilia , Xiang Wang , Allen Angier , Shokouhi Sepideh , Chetty Satish Casie , Barnes Gina , Iqbal Zohora , Tsou Peiling , Singh Navan , Calvert Jacob , Hurtado Myrna , Hoffman Jana , Mao Qingqing 
Published: June 2022

Abstract
Importance: Despite sex and race disparities in the symptom presentation, diagnosis, and management of acute coronary syndrome (ACS), these differences have not been investigated in the development and validation of machine learning (ML) models using individualized patient information from electronic health records (EHRs) to diagnose ACS. Objective: To evaluate ML-based ACS diagnosis performance across different subpopulations in a multi-site emergency department (ED) setting and determine how bias mitigating techniques influence ML performance. Design, Setting, and Participants: This retrospective observational study included data from 2,334,316 ED patients ( >18 years) from January 2007 to June 2020. Exposure: Logistic regression (LR) and neural network (NN) models were assessed in ED encounters grouped by sex, race, presence or absence of chest pain, EHR data quality, and timeliness of several key ED procedures. Prejudice regularization, reweighting, and within-subpopulation training were evaluated for bias mitigation. Main Outcomes/Measures: Metrics including area under the receiver operating characteristic (AUROC) were used to assess performances. Results: We analyzed 4,268,165 ED visits in which patient demographics by race were 67.40% White, 19.20% Black, 2.40% Asian, and 11.00% Other or Unknown. Patient composition was 54.80% female and 45.20% male. Both models’ AUROCs were significantly higher in White vs. Black patients (LR: z-score = 3.23 and NN: 4.26 for NN; P < 0.0006), in males vs. females (z-score = 3.81 for LR and 4.16 for NN; P < 0.0001) and in no chest pain subpopulation vs. chest pain (z-score = 13.32 for LR and 17.70 for NN; P < 0.0001). Prejudice regularization and reweighting techniques did not reduce biases. Training in race-specific and sex-specific training populations also did not yeild statistically signficant improvements in ML algorithm performance. Chest pain-specific training led to significantly improved AUROC.Conclusion: EHR-derived ML models trained and tested within similar demographic subpopulations and symptom groups may perform better than ML models that are trained in random populations, and provide less biased clinical decision support for ACS diagnosis.
Source attribution of campylobacteriosis in Australia circa 2018
Authors: McLure Angus , Smith James J , Firestone Simon Matthew , Kirk Martyn D , French Nigel , Fearnley Emily , Wallace Rhiannon , Valcanis Mary , Bulach Dieter , Moffatt Cameron , Selvey Linda A , Jennison Amy , Glass Kathryn 
Published: June 2022

Abstract
Background: Campylobacter spp. infections are the leading cause of foodborne gastroenteritis in high-income countries, including Australia. Campylobacter colonises a variety of mammalian and avian hosts that are reservoirs for human campylobacteriosis. Though most Australian outbreak investigations implicate chicken meat, the proportions of sporadic cases attributable to different animal reservoirs are unknown. Methods: Campylobacter isolates were obtained from notified human cases, and raw meat and offal from the major livestock in Australia: chickens, pigs, and ruminants (cattle and sheep) between 2017 and 2019. Isolates were speciated, with sequence types determined using multi-locus sequence genotyping. We used Bayesian source attribution models to estimate the proportion of human cases attributable to each livestock source by comparing the frequency of sequence types in cases and each animal source. We employed a model comparison approach with ten base models and explored adjusting these for age, gender, jurisdiction, rurality, and season. Four of the ten base models included an ‘unsampled’ source to estimate the proportion of cases attributable to wild, feral, or domestic animal reservoirs not sampled in our study. Results: We included 612 food and 710 human case isolates. The best fitting models attributed >80% of Campylobacter cases to chickens, with a greater proportion of Campylobacter coli (>84%) than Campylobacter jejuni (>77%). The best fitting model that included an unsampled source attributed 14% (95% CrI: 0.3-32%) to the unsampled source and only 2% to ruminants (95% CrI: 0.3-12%) and 2% to pigs (95% CrI: 0.2-11%.) The best fitting model that did not include an unsampled source attributed 12% to ruminants (95%CrI: 1.3-33%) and 6% to pigs (95%CrI: 1.1-19%.) Model fit was not improved by inclusion of case covariates. Conclusions: Chickens were the leading source of Campylobacter infections in our data and should remain the focus of interventions to reduce the burden in Australia.
Nano cellulose as Sustainable green material for Multi Biological applications via ξ Potential
Authors: Mahmoud Sara Mohamed , Ali Safwat Hassan , Omar Mohamd Abdelhady 
Published: June 2022

Abstract
The present study aims to disclose the novel activity of cellulose in nanoparticles as antioxidants, antimicrobials, antitumors and its effect on lymphocyte proliferation activity as an index of immunity.
Results show that surface charge & particle size distribution of nano cellulose reveal positive zeta potentials with average values +27 mv, and size range 4.4 nm in diameter. While IC50 of antioxidants capacity was 42.1µg/mL, meanwhile antimicrobial activity impact on G-ve strains at different concentration, but not affected on tested G+ve strains and tested fungi. Also, cytotoxicity show minority for nanoparticles of cellulose. Moreover, lymphocyte proliferation assay appears highly significant effect for nano cellulose. On the other hand, antitumor power of nano cellulose on Caco-2 cancer cells was dose dependent. In addition, comet values show significant influence at dose 500 μg/mL. These findings show that cellulose play a critical role in nanoparticles when compared to conventional molecules, and that they have a remarkable physical and biological activity, indicating a promising trend for using these nano molecules in a variety of biological applications.
Dynamics and Stability of Magnetic-air Hybrid Quasi-zero Stiffness Vibration Isolation System
Authors: Jiang Youliang , Song Chunsheng , Ma Xin , Wu Han , Mai Zhihui 
Published: June 2022

Abstract
With the improvement of machining accuracy, external low frequency vibration has become one of the most important factors affecting the performance of equipment. The theory of quasi-zero stiffness vibration isolation shows favorable low frequency vibration isolation effect. Based on our previous research on the structure of magnetic-air hybrid quasi-zero stiffness vibration isolation system, the nonlinear mechanical expression of positive and negative stiffness structure has been analyzed in this paper, to improve application of the system and provide a theoretical basis for sequential studies of active control. To analyze the judgement criterion of the quasi-zero stiffness, an accurate mechanical model was first established. Then, the dynamical model based on external low frequency vibration was developed, to investigate the stability and natural frequency and deduce. At the same time, the influence of different feedback parameters on the amplitude frequency characteristics has been discussed. Finally, we carried out simulation and experimental analysis to verify the stiffness of high static and low dynamic and the low frequency vibration isolation effect of the vibration isolation system.
Specific Cleavage of the Gln15-Lys16 Bond In β -Amyloid Peptides By Porcine Vasoactive Intestinal Polypeptide-Degrading Endopeptidase
Authors: Jeohn Gwang-Ho , Takahashi Kenji 
Published: June 2022

Abstract:
The action of porcine vasoactive intestinal polypeptide-degrading endopeptidase toward 6-amyloid peptides (β AP) was investigated to shed further light on its substrate specificity. The protease was found to specifically cleave the Glnl5.-Lysl6 bond in β AP 1-28, β AP 1-28 [Glnll] and β AP 1-40. The P1 site specificity is consistent with the previous results with VIP, but does not account fully for the specificity of the enzyme. Secondary structure comparison among the peptides cleaved by this enzyme suggested that most cleavage sites are assigned within the regions with a specific secondary structure, especially a-helix.
Patient Safety Competencies among Senior Students of Health Professions: An Iranian Evaluation Study
Authors: Alidousti-Shahraki Niloofar , Farzi Sedigheh , Tarrahi Mohammad Javad 
Published: June 2022

Introduction:
Patient safety refers to preventing and reducing adverse events that might harm the patient while providing care. Enhancing patient safety competence upon entering the clinical environment requires introducing and integrating it in health professions' education.

Aim:
This study aimed to investigate patient safety competence among senior health professions students.

Methods:
This study was conducted in 2020 using a cross-sectional study. In total, 390 senior health professions students of Isfahan University of Medical Sciences, Isfahan, Iran, including medicine, nursing, pharmacy, midwifery, surgical technologist (operating room technician), and anesthesia were selected through a stratified convenience method. Data were collected using the Health Professional Education in Patient Safety Survey – H-PEPSS from August to September 2020 and analyzed using descriptive and analytical statistics. All statistical computations were carried out using SPSS version 16. A significant level of 5% was considered (P <0.05).

Results:
The mean scores of patient safety in health professions education in the classroom and clinical setting were 0.51 and 0.47, respectively. Among Health Professional Education in Patient Safety Survey – H-PEPSS domains, the highest mean score was obtained in the effective communication domain (0.61 in the classroom and 0.57 in the clinical setting). In contrast, domains of working in teams with other health professions showed the lowest mean score (0.39 in the classroom and 0.38 in the clinical setting).

Conclusion:
Patient safety in health profession education, particularly working in teams with other health professions, is at a moderate level in the classroom and a weak level in the clinical setting. Regarding the importance of interprofessional collaboration in promoting patient safety, it is recommended that the health sciences curriculum in Iran be reviewed to motivate students for interprofessional collaboration and the perception of its significance in reducing health profession's errors.
The Birth of Pussy Riot: Six Early Songs
Authors: Hendrickson Jamie 
Published: June 2022

Vol 3. No. 2 (2022)
This issue of SourceLab introduces readers to the history of Pussy Riot, a Russian feminist punk rock band, through the lens of their early work.
This publication is part of the digital documentary edition series SourceLab, based at the University of Illinois at Urbana-Champaign. Our Editorial Board conducts rigorous peer-review of every edition.
eHealth Interventions for Dutch Cancer Care: Systematic Review Using the Triple Aim Lens
Authors: van Deursen Liza , Versluis Anke , van der Vaart Rosalie , Standaar Lucille , Struijs Jeroen , Chavannes Niels , Aardoom Jiska J 
Published: June 2022

Background
Globally, the burden of cancer on population health is growing. Recent trends such as increasing survival rates have resulted in a need to adapt cancer care to ensure a good care experience and manageable expenditures. eHealth is a promising way to increase the quality of cancer care and support patients and survivors.

Objective
The aim of this systematic review was 2-fold. First, we aimed to provide an overview of eHealth interventions and their characteristics for Dutch patients with and survivors of cancer. Second, we aimed to provide an overview of the empirical evidence regarding the impact of eHealth interventions in cancer care on population health, quality of care, and per capita costs (the Triple Aim domains).

Methods
The electronic databases Web of Science, PubMed, Cochrane, and Ovid PsycINFO were searched using 3 key search themes: eHealth interventions, cancer care, and the Netherlands. The identified interventions were classified according to predetermined criteria describing the intervention characteristics (eg, type, function, and target population). Their impact was subsequently examined using the Triple Aim framework.

Results
A total of 38 interventions were identified. Most of these were web portals or web applications functioning to inform and self-manage, and target psychosocial factors or problems. Few interventions have been tailored to age, disease severity, or gender. The results of this study indicate that eHealth interventions could positively affect sleep quality, fatigue, and physical activity of patients with and survivors of cancer. Inconclusive results were found regarding daily functioning and quality of life, psychological complaints, and psychological adjustment to the disease.

Conclusions
eHealth can improve outcomes in the Triple Aim domains, particularly in the population health and quality of care domains. Cancer-related pain and common symptoms of active treatment were not targeted in the included interventions and should receive more attention. Further research is needed to fully understand the impact of eHealth interventions in cancer care on participation, accessibility, and costs. The latter can be examined in economic evaluations by comparing eHealth interventions with care as usual.
Engaging veterans in the research process: a practical guide
Authors: Barker Anna M , Dunlap Shawn , Hartmann Christine W , Wilson-Menzfeld Gemma , McGill Gill 
Published: June 2022

Aims:
Provide guidance for engaging military veterans in various research teams to help overcome veterans' lack of trust in research.
Methods:
We draw from our combined experience to present four case studies of veteran research on sensitive topics to illustrate successful engagement with veterans.
Results:
For each case example, we describe veterans' contributions at different phases of research. We then share practical guidance for realizing benefits and overcoming challenges of engaging veterans in research at each phase. In our experience, successful engagement has built trust by aligning research with participants' own experience as veterans.
Conclusion:
Investigators wishing to engage veterans in research may benefit from the lessons presented through these case studies.