bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymph Node Yield in Gastrointestinal Cancer Surgery With or Without Prior Neoadjuvant Therapy: Protocol for a Systematic Review and Meta-analysis
Authors: Ronellenfitsch Ulrich , Mathis Nika , Friedrichs Juliane , Kleeff Jörg 
Published: March 2022

Background
Lymph node yield is the number of lymph nodes retrieved during oncological resection and histopathologically identified in the resection specimen. It is an important surrogate parameter for assessing the oncological radicality of the resection of gastrointestinal carcinomas, as well as a prognostic factor in these diseases. It remains unclear if and to what extent neoadjuvant chemotherapy, radiotherapy, or chemoradiotherapy, which have become established treatments for carcinoma of the esophagus, stomach, and rectum and are increasingly used in pancreatic carcinoma, affect the lymph node yield.

Objective
This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the lymph node yield, an oncological surrogate marker, in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant therapy compared to those undergoing surgery without neoadjuvant therapy.

Methods
Randomized and nonrandomized studies comparing oncological resection of esophageal, stomach, pancreatic, and rectal carcinoma with and without prior neoadjuvant therapy are eligible for inclusion regardless of study design. Publications will be identified with a defined search strategy in 2 electronic databases: PubMed and Cochrane Library. The primary endpoint of the analysis is the number of lymph nodes identified in the resected specimen. Secondary endpoints include the number of harvested metastatic lymph nodes, operation time, postoperative complications, pathological TNM staging, and overall and recurrence-free survival time. Using suitable statistical methods, the endpoints between patients with and without neoadjuvant therapy, as well as in defined subgroups (neoadjuvant chemotherapy, radiotherapy, or chemoradiotherapy; and patients with esophageal, gastric, pancreatic, or rectal cancer), will be compared.

Results
The literature search and data collection started in October 2021. Results are expected to be published in mid-2022.

Conclusions
This meta-analysis will provide the most up-to-date and complete summary of the evidence on an association between neoadjuvant therapy and lymph node yield in gastrointestinal cancer surgery. The underlying hypothesis is that neoadjuvant therapy decreases the number and size of lymph nodes through lymphocyte depletion and radiation-induced fibrosis, thus leading to a lower possible lymph node yield. The findings of the meta-analysis will show if this hypothesis is supported by evidence.

Trial Registration
PROSPERO CRD218459; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021218459

International Registered Report Identifier (IRRID)
DERR1-10.2196/35243
3 Co-TEAM: A logic model for pharmacy health coaching among substance use disorders patients
Authors: Haryono Alexxander , Ika Puspitasari  , Susi Ari Kristina  , Cecep Sugeng Kristanto  , Erna Prihandiwati  
Published: March 2022

ABSTRACT
Background: Pharmacy health coaching on various chronic diseases has been widely used with promising results. Drug addiction is a chronic disease, however, the intervention model of pharmacy health coaching in these patients has not been previously reported.
Objective: Developing a logic model for pharmacy health coaching among substance use disorders patients that can be used by community pharmacists as a tool to support development, innovation, monitoring, and evaluating the performance of pharmacy health coaching.
Methods: A logic model used to develop an intervention model of pharmacy health coaching following a process consisting of four steps: (1) a literature review to identify key values, scope, delivery & tools, the content of the session, and competencies for pharmacy health coaching; (2) focus groups discussion (FGD) to obtain information from specific sources and discuss the results of the literature review; (3) developing a logic model based on the finding from steps 1 and 2; and (4) FGD to discuss and fine-tune the model.
Results: A logic model was successfully constructed and generated 3 Co-TEAM models for pharmacy health coaching among substance use disorders patients. The 3 Co-TEAM consists of communication, collaboration, consultation, training, education, attitude, and motivational interviewing.
Conclusion: The 3 Co-TEAM model for pharmacy health coaching provides steps to implement this service in an objective, organized and comprehensive manner. The proposed model can function as a tool that provides guidance and reference for pharmacists in the process of implementing pharmacy health coaching among substance use disorders patients and collaborating with other health professionals.

Keywords: logic model, pharmacy health coaching, substance use disorders, pharmaceutical services, patient-centered care
Improving the Sphere of Customs Administration in Russia Based on the Chinese Experience
Authors: Vorona A. A. , Kalmykov S. P. , Lyashenko M. V. 
Published: March 2022

The widespread use of new technologies based on digitalization has recently intensified, due to the processes associated with changes in business organization. Serious attention is paid to this direction of development by business representatives engaged in economic activities in international trade and governments of the leading economies of the world, including China and Russia. The introduction of digitalization processes in various sectors of the economy has become a conscious necessity. In order to theoretically substantiate and subsequently achieve the necessary level of development of information technologies and communications, analytical studies and testing of changes in this area are being conducted in many countries. The economy based on the introduction of digital technologies determines the vector of development of the economies of countries for the long term.Aim. Analyze the digital transformation of the Chinese economy, identify positive experience in the application of digital solutions and their impact on the simplification of customs procedures and correlate the results with Russia.Tasks. Consider technological trends in digital transformation; to study the results of the policy in carrying out the digitalization of the economy of China and Russia; to consider possible promising areas for the development of cooperation between China and Russia in the field of digital.Methods. Statistical analysis of data and synthesis of the results obtained for comparison purposes.Results. As a result of the study, the following results were obtained: a) a comparative analysis of the changes in the values of indicators on the Global Connectivity Index (GCI) of China and Russia in 2020 compared to 2015 was carried out, the reasons for the changes that occurred were substantiated; b) the dynamics of exports and imports of China, as well as data on trade turnover between China and Russia for the period from 1991 to October 2021; c) the experience of customs administration in China is considered and possible directions of its application in Russia are determined.Conclusion. The positive experience of China’s customs administration in the light of the digitalization of economic processes can be used in Russia, which can certainly improve the current situation in the field of customs administration in our country.
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Authors: Limonte Christine P. , Valo Erkka , Drel Viktor , Natarajan Loki , Darshi Manjula , Forsblom Carol , Henderson Clark M. , Hoofnagle Andrew N. , Ju Wenjun , Kretzler Matthias , Montemayor Daniel , Nair Viji , Nelson Robert G. , O’Toole John F. , Toto Robert D. , Rosas Sylvia E. , Ruzinski John , Sandholm Niina , Schmidt Insa M. , Vaisar Tomas , Waikar Sushrut S. , Zhang Jing , Rossing Peter , Ahluwalia Tarunveer S. , Groop Per-Henrik , Pennathur Subramaniam , Snell-Bergeon Janet K. , Costacou Tina , Orchard Trevor J. , Sharma Kumar , de Boer Ian H. ,   for the Kidney Precision Medicine Project
Published: April 2022

OBJECTIVE
Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
We performed a case-control study nested within four T1D cohorts to identify urinary proteins associated with rapid eGFR decline. Case and control subjects were categorized based on eGFR decline ≥3 and &lt;1 mL/min/1.73 m2/year, respectively. We used targeted liquid chromatography–tandem mass spectrometry to measure 38 peptides from 20 proteins implicated in diabetic kidney disease. Significant proteins were investigated in complementary human cohorts and in mouse proximal tubular epithelial cell cultures.

RESULTS
The cohort study included 1,270 participants followed a median 8 years. In the discovery set, only cathepsin D peptide and protein were significant on full adjustment for clinical and laboratory variables. In the validation set, associations of cathepsin D with eGFR decline were replicated in minimally adjusted models but lost significance with adjustment for albuminuria. In a meta-analysis with combination of discovery and validation sets, the odds ratio for the association of cathepsin D with rapid eGFR decline was 1.29 per SD (95% CI 1.07–1.55). In complementary human cohorts, urine cathepsin D was associated with tubulointerstitial injury and tubulointerstitial cathepsin D expression was associated with increased cortical interstitial fractional volume. In mouse proximal tubular epithelial cell cultures, advanced glycation end product–BSA increased cathepsin D activity and inflammatory and tubular injury markers, which were further increased with cathepsin D siRNA.

CONCLUSIONS
Urine cathepsin D is associated with rapid eGFR decline in T1D and reflects kidney tubulointerstitial injury.
Aplicación de la Estrategia Multimodal de Higiene de Manos en el Hospital de Especialidades Eugenio Espejo. Enero a Diciembre del 2017
Authors: Salazar Viviana , Sánchez J. , Tufiño V. , Valle M. , Bastidas N. , Suntaxi M. , Pozo A. , Peña A. 
Published: March 2022

Introducción: Las infecciones asociadas a la atención en salud, son un problema de salud pública a nivel mundial y para su prevención y control es necesario contar con sistemas de vigilancia permanente y aplicar medidas de probada evidencia. La Organización Mundial de la Salud lanzó el programa de Higiene de manos, con probados beneficios. Por ello para mejorar la adherencia a la higiene de manos en el personal sanitario del hospital Espejo, se implementó este proyecto piloto.
Objetivo: Evaluar la aplicación de la Estrategia Multimodal de Higiene de Manos.
Lugar: en el Hospital de Especialidades Eugenio Espejo
Tiempo: desde enero a diciembre del 2017.
Diseño: Se realizó un estudio observacional descriptivo.
Resultados: Al analizar los resultados obtenidos se ve que la mayor adherencia a la higiene de manos es el segundo momento (antes de una actividad aséptica) con un porcentaje del 78,3%, mientras que la menor adherencia es durante el quinto momento (después del contacto con el entorno) con el 36,6%. Sin embargo luego de la aplicación de la estrategia se evidencia un incremento de esta adherencia del 9,54 al 28,3% en tres de los momentos. Igualmente se evidencia un incremento en la utilización de alcohol gel lo cual es un indicador del impacto que tienen las capacitaciones en el personal de salud del hospital.
Conclusiones: Con la aplicación de la estrategia se evidenció un incremento en la adherencia de higiene de manos por parte del personal de salud.
Studies on Nutrient and Mineral Contents of Fluted Pumpkin Grown in NPK Solution
Authors: Agogbua Josephine U. , Okonwu Kalu , Akonye Love A. , Mensah Stephen I. 
Published: March 2022

Studies on nutrient and mineral contents of fluted pumpkin, Telfairia occidentalis Hooker fil. leaves grown in different NPK 20-10-10 solutions. The solutions varied in the amount of NPK (20-10-10) and granules (25 g, 50 g, 75 g, 100 g, 125 g and 150 g, respectively) dissolved in water containing micronutrients. The growth media were M25NPK, M50NPK, M75NPK, M100NPK, M125NPK, M150NPK, and Control. Two-week old seedlings of fluted pumpkin raised using River-sand were transferred into the growth media; in four replicates. The nutrient (proximate composition, vitamins, and amino acids) and minerals were determined 5 weeks after planting (WAP) following standard procedures. Among the growth media, fluted pumpkin grown in M125NPK medium had the highest energy level (1622.12 KJ/100 g) while the lowest energy content (1437.43 KJ/100g) was recorded at M25NPK medium. Fluted pumpkin grown in M25NPK medium had the lowest percentage crude fibre content, crude fat, fatty acid when compared with other growth media. The leaves grown in M75NPK medium had the highest value for total vitamins (water-soluble and fat-soluble). The percentage ratio of EAA to NEAA for the growth media was Control (42.33:57.67), M25NPK (38.88:61.12), M50NPK (40.45:59.55), M75NPK (42.06:57.94), M100NPK (41.04:58.96), M125NPK (45.97:54.03) and M150NPK (41.54:58.46). The results recorded indicated that the proportion of the minerals varied in the hydroponic solutions. The nutrient contents of fluted pumpkin leaves grown in the NPK 20-10-10 media varied at P ≤ 0.05. The proportion of mineral elements in fluted pumpkin leaves grown under different concentrations of NPK media at 5 WAP varies in their concentrations.
Pathogenicity of Aeromonas hydrophila in Cultured African Catfish (Clarias gariepinus)
Authors: Mohamad Nora Faten Afifah , Mohd Daud Hassan , Sharifah Raina Manaf  
Published: March 2022

Aeromonas infections are becoming a serious risk issue in commercial aquaculture, and a wide range of fish and shellfish species has been documented as being vulnerable. Five isolates of Aeromonas hydrophila were identified from African catfish (Clarias gariepinus) cultured in Selangor, West Malaysia in this study. A conventional rapid identification approach (API 20E strip) was used for preliminary identification based on the biochemical properties of the isolated bacteria. Polymerase chain reaction (PCR) with the specific primer 16 rDNA, on the other hand, was used as an accurate and confirmed identification. A pathogenicity test via intramuscular (IM) injection was used to investigate the virulence of A. hydrophila. With a high degree of similarity (98%) to the NCBI or Genbank databases, the isolates were identified as A. hydrophila. The LD50 was calculated using pathogenicity test findings and was found to be 2.1 ´ 106.33 CFU mL−1, while 1 ´ 108 CFU mL−1 in the experimentally injected fish, resulted in 100% mortality. Several organs, including the kidney, liver, and spleen, showed histopathological abnormalities. Those changes mainly include increase in the presence of hemosiderin deposits, congested portal vessels, vacuolated hepatocytes, generalised loss of tubular cells, and oedematous degeneration in the infected organs.
Self-Islah, Gender Relation and Socio-Economic Challenges on Tablighi Jamaat Proselytization Practices in Indonesia
Authors: Hamdi Saipul , Mulyadi Fadli , Tondo Fanny Henry , Muzayyin Ahmad 
Published: March 2022

This article explores one of the Tablighi Jamaat (TJ) teachings self-islah that develops in its dawah practices. Self-Islah emphasizes improving oneself through a proselytization program called khuruj from one community to another, from one mosque to another. The phenomenon of TJ dawah shows a different approach and pattern where da’i play dual roles not only as subject (preachers) but also as an object (listeners) during that khuruj program. Self-islah in this context includes strengthening faith, morals, and gender awareness. The gender aspect is strong external critics of TJ religious tradition where it does not involve women in their religious activities and even avoids interacting with them. Thus, TJ members must handle all the needs while staying in the mosque for religious camps, such as washing clothes, cooking, washing dishes, and serving guests from the local and international community. The article investigates changes in gender relations within the TJ family in the post-khuruj program. This article also focuses on the economic challenges Tablighi members face when they go out of preaching (khuruj), especially those from the lower-middle class. The research findings show that most TJ members achieved self-Islah and hugely impacted the evolution of spirituality after khuruj. They also acknowledged the transformation of gender relations in the family, but on another side, facing economic crises due to prioritizing dawah activity. I used an ethnographic approach and applied a qualitative method in collecting and analyzing data for two years (2017-2018) in three research locations, Lombok, Balikpapan, and Jakarta.
Asymptotic Results of a Nonparametric Conditional Quantile Estimator in the Single Functional Index Modeling under Random Censorship
Authors: Kadiri Nadia , Rabhi Abbes , Akkal Fatima 
Published: March 2022

Abstract
The main objective of this paper is to estimate non-parametrically the quantiles of a conditional distribution based on the single-index model in the censorship model when the sample is considered as an independent and identically distributed (i.i.d.) random variables. First of all, a kernel type estimator for the conditional cumulative distribution function (cond-cdf) is introduced. Afterwards, we give an estimation of the quantiles by inverting this estimated cond-cdf, the asymptotic properties are stated when the observations are linked with a single-index structure. Simulation study is also presented to illustrate the validity and finite sample performance of the considered estimator. Finally, the estimation of the functional index via the pseudo-maximum likelihood method is discussed, but not tackled.
Military Necessity and Cultural Heritage Protection in Laws of War: Historical Overview
Authors: Ryška Ivan 
Published: March 2022

Summary
The article examines the development of the concept of military necessity in relation to cultural property. Starting from 18th century and Emmerich de Vattel it continues to codifications of International Humanitarian Law in 19th century and finally focuses on 1954 Hague Convention and its 1999 Second Protocol. The article underlines the most significant trends in the development and aims to illustrate increasing respect for cultural property during the conflict. In its final section it presents more current issues related to cultural property protection and armed conflict: inclusion of human rights protection and matter of dual-use objects. Both questions are introduced in decision of the International Criminal Tribunal for the Former Yugoslavia in Prlić et al. case that investigates destruction of Stari Most in Mostar. The decision shows that some new elements have to be considered in assessment of military necessity related to cultural property.
Estimating Weights for Web-Scraped Data in Consumer Price Indices
Authors: Ayoubkhani Daniel , Thomas Heledd 
Published: March 2022

Abstract
In recent years, there has been much interest among national statistical agencies in using web-scraped data in consumer price indices, potentially supplementing or replacing manually collected price quotes. Yet one challenge that has received very little attention to date is the estimation of expenditure weights in the absence of quantity information, which would enable the construction of weighted item-level price indices. In this article we propose the novel approach of predicting sales quantities from their ranks (for example, when products are sorted ‘by popularity’ on consumer websites) via appropriate statistical distributions. Using historical transactional data supplied by a UK retailer for two consumer items, we assessed the out-of-sample accuracy of the Pareto, log-normal and truncated log-normal distributions, finding that the last of these resulted in an index series that most closely approximated an expenditure-weighted benchmark. Our results demonstrate the value of supplementing web-scraped price quotes with a simple set of retailer-supplied summary statistics relating to quantities, allowing statistical agencies to realise the benefits of freely available internet data whilst placing minimal burden on retailers. However, further research would need to be undertaken before the approach could be implemented in the compilation of official price indices.
Substitution Bias in the Measurement of Import and Export Price Indices: Causes and Correction
Authors: von Auer Ludwig , Shumskikh Alena 
Published: March 2022

Abstract
The import and export price indices of an economy are usually compiled by some Laspeyres type index. It is well known that such an index formula is prone to substitution bias. Therefore, also the terms of trade (ratio of export and import price index) are likely to be distorted. The underlying substitution bias accumulates over time. The present article introduces a simple and transparent retroactive correction approach that addresses the source of the substitution bias and produces meaningful long-run time series of import and export price levels and, therefore, of the terms of trade. Furthermore, an empirical case study is conducted that demonstrates the efficacy and versatility of the correction approach.
Rolling-Time-Dummy House Price Indexes: Window Length, Linking and Options for Dealing with Low Transaction Volume
Authors: Hill Robert J. , Scholz Michael , Shimizu Chihiro , Steurer Miriam 
Published: March 2022

Abstract
Rolling-time-dummy (RTD) is a hedonic method used by a number of countries to compute their official house price indexes (HPIs). The RTD method requires less data and is more adaptable than other hedonic methods, which makes it well suited for computing higher frequency HPIs (e.g., monthly or weekly). In this article, we address three key issues relating to RTD. First, we develop a method for determining the optimal length of the rolling window. Second, we consider variants on the standard way of linking the current period with earlier periods, and show how the optimal linking method can be determined. Third, we propose three ways of modifying the RTD method to make it more robust to periods of low transaction volume. These modifications could prove useful for countries using the RTD method in their official HPIs.