bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear Progestin Receptor–mediated Linkage of Blood Coagulation and Ovulation
Authors: Huang Jing , Sun Chao , Teng Liu Dong , Zhao Nan Nan , Shavit Jordan A , Zhu Yong , Chen Shi Xi 
Published: May 2022

Abstract
Ovulation is a dramatic remodeling process that includes rupture of blood capillaries and clotting, but coagulation is not thought to directly regulate this process. Herein, we report remarkable increases of coagulation factors V (f5, ~3145-fold) and tissue factor (f3a, ~120-fold) in zebrafish ovarian follicle cells during ovulation. This increase was mediated through the nuclear progestin receptor (Pgr), which is essential for ovulation in zebrafish, and was totally abolished in ovarian follicular cells from pgr–/– mutants. In addition, promoter activities of f5 and f3a were significantly enhanced by progestin (DHP) via Pgr. Similar regulation of human F5 promoter activity was induced via human PGRB, suggesting a conserved mechanism. Site-directed mutagenesis of the zebrafish f5 promoter further demonstrated a direct regulation of coagulation factors via progestin response elements. Moreover, a stark increase of erythrocytes occurred in capillaries meshed in wild-type preovulatory follicles but was absent in pgr–/– mutants. Interestingly, anticoagulants significantly inhibited ovulation both in vitro and in vivo, respectively. Furthermore, reduced fecundity was observed in f5+/– female zebrafish. Taken together, our study provides plausible evidence for steroid regulation of coagulation factors, and a new hypothesis for blood clotting–triggered ovulation in vertebrates.
Interplay Between GH-regulated, Sex-biased Liver Transcriptome and Hepatic Zonation Revealed by Single-Nucleus RNA Sequencing
Authors: Goldfarb Christine N , Karri Kritika , Pyatkov Maxim , Waxman David J 
Published: May 2022

Abstract
The zonation of liver metabolic processes is well-characterized; however, little is known about the cell type-specificity and zonation of sexually dimorphic gene expression or its growth hormone (GH)-dependent transcriptional regulators. We address these issues using single-nucleus RNA-sequencing of 32 000 nuclei representing 9 major liver cell types. Nuclei were extracted from livers from adult male and female mice; from males infused with GH continuously, mimicking the female plasma GH pattern; and from mice exposed to TCPOBOP, a xenobiotic agonist ligand of the nuclear receptor CAR that perturbs sex-biased gene expression. Analysis of these rich transcriptomic datasets revealed the following: 1) expression of sex-biased genes and their GH-dependent transcriptional regulators is primarily restricted to hepatocytes and is not a feature of liver nonparenchymal cells; 2) many sex-biased transcripts show sex-dependent zonation within the liver lobule; 3) gene expression is substantially feminized both in periportal and pericentral hepatocytes when male mice are infused with GH continuously; 4) sequencing nuclei increases the sensitivity for detecting thousands of nuclear-enriched long-noncoding RNAs (lncRNAs) and enables determination of their liver cell type-specificity, sex-bias and hepatocyte zonation profiles; 5) the periportal to pericentral hepatocyte cell ratio is significantly higher in male than female liver; and 6) TCPOBOP exposure disrupts both sex-specific gene expression and hepatocyte zonation within the liver lobule. These findings highlight the complex interconnections between hepatic sexual dimorphism and zonation at the single-cell level and reveal how endogenous hormones and foreign chemical exposure can alter these interactions across the liver lobule with large effects both on protein-coding genes and lncRNAs.
The Social Life of Terror Capitalism Technologies in Northwest China
Authors: Byler Darren 
Published: May 2022

AbstractThis article examines the digital enclosure of Muslim minority data and labor through a techno-political “reeducation” system in Northwest China to make a broader argument about the way surveillance capitalism can be linked to ethno-racialization. Specifically, it considers how Chinese state capital investment incentivizes technology companies to engage in the dataveillance of ethno-racialized populations to generate what the article names terror capitalism. Drawing on two years of ethnographic research, interviews with former detainees, and analysis of internal police reports, and written in conversation with feminist anthropological scholarship on capitalism and social reproduction, it argues that these systems have created a matrix of conversion devices that produce Muslim social life under the sign of terrorism while expropriating it as data and labor. At the same time these systems, ultimately, are vulnerable to outside interception—opening them to a partial reversal of the surveillant gaze.
Get Unstuck!
Authors: Gill Rosalind , Orgad Shani 
Published: May 2022

AbstractExamining women's magazines and lifestyle coaching, the article explores how positivity imperatives in contemporary culture call forth a happy, confident, hopeful, and vibrant subject during the COVID-19 pandemic. The analysis shows how these positivity imperatives acknowledge stress and difficulty, and at times highlight their gendered impacts, yet nevertheless systematically figure responses and solutions in individual, psychological, and often consumerist terms. The discussion demonstrates how positivity imperatives operate not only through verbal advice but also through visual, embodied, and affective means and through an emphasis on developing new social practices—from holding one's body differently, to keeping gratitude journals, to cultivating a new virtual persona for online work meetings. The article highlights a profound paradox: in times of a global pandemic that has affected women disproportionally, and when structural injustices and inequalities have been made ever more visible, positivity and individualized self-care interpellations to women flourish, anger is muted, and critiques of structural inequality are largely silenced. Thus seemingly benign and often undoubtedly well-meaning messages of confidence, calm, and positivity during the pandemic work to buttress a neoliberal imaginary and persistent social inequalities.
Anti-symmetric Compton scattering in LiNiPO4: Towards a direct probe of the magneto-electric multipole moment
Authors: Bhowal Sayantika , O'Neill Daniel , Fechner Michael , Spaldin Nicola A. , Staub Urs , Duffy Jon , Collins Stephen P. 
Published: May 2022

Background: Magnetoelectric multipoles, which break both space-inversion and time-reversal symmetries, play an important role in the magnetoelectric response of a material. Motivated by uncovering the underlying fundamental physics of the magnetoelectric multipoles and the possible technological applications of magnetoelectric materials, understanding as well as detecting such magnetoelectric multipoles has become an active area of research in condensed matter physics. Here we employ the well-established Compton scattering effect as a possible probe for the magnetoelectric toroidal moments in LiNiPO4. Methods: We employ combined theoretical and experimental techniques to compute as well as detect the antisymmetric Compton profile in LiNiPO4. For the theoretical investigation we use density functional theory to compute the anti-symmetric part of the Compton profile for the magnetic and structural ground state of LiNiPO4. For the experimental verification, we measure the Compton signals for a single magnetoelectric domain sample of LiNiPO4, and then again for the same sample with its magnetoelectric domain reversed. We then take the difference between these two measured signals to extract the antisymmetric Compton profile in LiNiPO4. Results: Our theoretical calculations indicate an antisymmetric Compton profile in the direction of the ty toroidal moment in momentum space, with the computed antisymmetric profile around four orders of magnitude smaller than the total profile. The difference signal that we measure is consistent with the computed profile, but of the same order of magnitude as the statistical errors and systematic uncertainties of the experiment. Conclusions: While the weak difference signal in the measurements prevents an unambiguous determination of the antisymmetric Compton profile in LiNiPO4, our results motivate further theoretical work to understand the factors that influence the size of the antisymmetric Compton profile, and to identify materials exhibiting larger effects.
On the Benefit of Privatization in a Mixed Duopoly Service System
Authors: Zhou Wenhui , Huang Weixiang , Hsu Vernon N. , Guo Pengfei 
Published: May 2022

We consider a mixed duopoly service system with two service providers (SPs): one private and the other public. The public SP’s objective is welfare maximization, whereas the private SP is profit driven. Customers are heterogeneous in terms of their quality tastes and choose from three options, namely, joining the private queue, joining the public queue, and balking (or taking an outside option). We first consider the scenario where the private SP provides a premium service and the public SP provides a regular service. Paradoxically, we find that although the public SP’s objective is welfare maximization, welfare in the system can be less than that obtained with only profit-seeking private SPs. We further demonstrate that the maximum social welfare is achieved by partially privatizing the public SP, that is, by including both welfare and profit maximization as arguments in its objective function. In extreme cases in which the public SP’s capacity is very small, fully privatizing the public SP can be socially desirable. We then consider the alternate setting where the public SP provides a premium service and the private SP provides a regular service and obtain similar conclusions. These findings, however, rely on the assumption that an outside option exists for balking customers, and one should be cautious in generalizing to no-balking situations. This paper was accepted by Jayashankar Swaminathan, operations management. Funding: W. Zhou was supported by the National Natural Science Foundation of China [Grants 71925002 and 71731006]. W. Huang acknowledges the financial support from the National Natural Science Foundation of China [Grants 71801096 and 72101090] and the Guangdong Basic and Applied Basic Research Foundation [Grant 2022A1515011983]. V. N. Hsu was supported by the General Research Fund of the Hong Kong Research Grants Council [Grant CUHK14526216]. P. Guo received financial support from the Hong Kong Research Grants Council [Grant 15502820]. Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2022.4424 .
Association of microvascular biomarkers in fluorescein angiography with macrovascular-related mortality in clinical routine data
Authors: Goldbach Felix , Mylonas Georgios , Riegelnegg Martin , Brugger Jonas , Schmidt-Erfurth Ursula , Gerendas Bianca S. 
Published: May 2022

Purpose
Early detection of microvascular changes in the retina may be important for the risk assessment of cardiovascular health. Therefore, the purpose of this study was to investigate imaging biomarkers in fluorescein angiography (FA) as potential predictors for cardiovascular mortality.

Methods
In this retrospective, matched case-control study, we included FA images from clinical routine data between 2007 and 2018 of 100 patients who died of macrovascular events (Group 1) and 100 age- and sex-matched controls (Group 2). All patients were under treatment for different, mostly retinal, ocular diseases. FA images were used for the measurement of the foveal avascular zone (FAZ) and the arteriolar and venular caliber.

Results
Patients mean age on examination day was 69.5 ± 8.3 years with a 1:1 female:male subject ratio. Mean FAZ area of our sample was 0.340 ± 0.135 mm2 for Group 1 and 0.264 ± 0.137 mm2 for Group 2 (P < 0.001), showing a larger FAZ area in patients who subsequently died of macrovascular-related systemic diseases.

Conclusions
Individuals effected by a macrovascular-related disease show a larger FAZ on FA examinations before the event compared to patients which are unaffected. Our results highlight a possible role of the FAZ as additional biomarker for the cardiovascular condition.
Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years: A systemic review
Authors: Mourino Nerea , Ruano-Raviña Alberto , Varela Lema Leonor , Fernández Esteve , López María José , Santiago-Pérez María Isolina , Rey-Brandariz Julia , Giraldo-Osorio Alexandra , Pérez-Ríos Mónica 
Published: May 2022

Background
Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cut-points used to classify children under 5 years as exposed to SHS.

Methods
A systematic review performed in the Pubmed (MEDLINE) and EMBASE databases up to April 2021 was conducted using as key words "serum cotinine", “tobacco smoke pollution” (MeSH), "secondhand smoke", "environmental tobacco smoke" and “tobacco smoke exposure”. Papers which assessed SHS exposure among children younger than 5 years old were included. The PRISMA 2020 guidelines were followed. Analysis was pre-registered in PROSPERO (registration number: CRD42021251263).

Results
247 articles were identified and 51 fulfilled inclusion criteria. The selected studies were published between 1985–2020. Most of them included adolescents and adults. Only three assessed postnatal exposure exclusively among children under 5 years. None of the selected studies proposed age-specific cut-points for children < 5 years old. Cut-point values to assess SHS exposure ranged from 0.015 to 100 ng/ml. The most commonly used cut-point was 0.05 ng/ml, derived from the assay limit of detection used by the National Health and Nutrition Examination Survey (NHANES).

Conclusions
No studies have calculated serum cotinine age-specific cut-points to ascertained SHS exposure among children under 5 years old. Children’s age-specific cut-points are warranted for health research and public health purposes aimed at accurately estimating the prevalence of SHS exposure and attributable burden of disease to such exposure, and at reinforcing 100% smoke-free policies worldwide, both in homes, private vehicles and public places.
Household water and food insecurity negatively impacts self-reported physical and mental health in the Vietnamese Mekong Delta
Authors: Vuong Thuy Ngoc , Dang Chinh Van , Toze Simon , Jagals Paul , Gallegos Danielle , Gatton Michelle L. 
Published: May 2022

IntroductionHousehold food insecurity and inadequate water, sanitation, and hygiene (WASH) contribute to ill health. However, the interactions between household food insecurity, WASH and health have been rarely assessed concurrently. This study investigated compounded impacts of household food insecurity and WASH on self-reported physical and mental health of adults in the Vietnamese Mekong Delta.Materials and methodsThis cross-sectional survey interviewed 552 households in one northern and one southern province of the Vietnamese Mekong Delta. The survey incorporated previously validated tools such as the Short Form 12-item Health Survey, Household Food Insecurity Assessment Scale, and the Access and Behavioural Outcome Indicators for Water, Sanitation, and Hygiene. Physical and mental health were quantified using the physical health composite score (PCS) and mental health composite score (MCS), respectively. These measures were the dependent variables of interest for this study.ResultsStatistical analysis revealed that household food insecurity and using <50 litres of water per person per day (pppd) were independently associated with lower PCS (p<0.05), after adjusting for socio-economic confounders. Household food insecurity and lack of food availability, using <50 litres of water pppd, and the use of untreated drinking water were associated with lower MCS (p<0.05), with water usage being an effect modifier of the relationship between household food insecurity and MCS. The results indicate that being food insecure and having limited potable quality water had a compounding effect on MCS, compared to being individually either food insecure or having limited water.ConclusionThis study is one of only a few that have established a link between potable water availability, food insecurity and poorer physical and mental health. The results also indicate a need to validate national data with fine-scale investigations in less populous regions to evaluate national initiatives with local populations that may be at higher risk. Adopting joint dual-action policies for interventions that simultaneously address water and food insecurity should result in larger improvements in health, particularly mental health, compared to targeting either food or water insecurity in isolation.
Gross motor skills trajectory variation between WEIRD and LMIC countries: A cross-cultural study
Authors: Valentini Nadia Cristina , Nobre Glauber Carvalho , Gonçalves Duarte Marcelo 
Published: May 2022

Aim
This study aimed to examine the prevalence of delays and borderline impaired performance for Brazilian girls and boys and the differences in the motor trajectories (locomotor and ball skills) of girls and boys (3- to 10-years-old) across WEIRD (Western, Educated, Industrial, Rich, and Democratic) countries and Brazil–a low- and middle-income country (LMIC).

Methods
We assessed 1000 children (524 girls; 476 boys), 3- to 10.9-year-old (M = 6.9, SD = 2.1; Girls M = 6.9, SD = 2.0; Boys M = 6.9, SD = 2.1), using the Test of Gross Motor Development-3. Using systematic search, original studies investigating FMS in children using the TGMD-3 were eligible; 5 studies were eligible to have the results compared to the Brazilian sample. One sample t-test to run the secondary data from Irish, American, Finnish, and German children (i.e., mean, standard deviation).

Results
The prevalence of delays and borderline impaired performance was high among Brazilian girls (28.3% and 27.5%) and boys (10.6% and 22.7%). The cross-countries comparisons showed significant (p values from .048 and < .001) overall lower locomotor and ball skills scores for Brazilian children; the only exceptions were skipping, catching, and kicking. We observed stability in performance, across countries, after 8-years-old, and no ceiling effects were found in the samples.

Conclusions
The Brazilian sample emphasized the need for national strategies to foster children’s motor proficiency. Differences in motor opportunities may explain the differences in motor trajectories between children in WEIRD and LMIC countries.
Clinician perspectives on what constitutes good practice in community services for people with complex emotional needs: A qualitative thematic meta-synthesis
Authors: Troup Jordan , Lever Taylor Billie , Sheridan Rains Luke , Broeckelmann Eva , Russell Jessica , Jeynes Tamar , Cooper Chris , Steare Thomas , Dedat Zainab , McNicholas Shirley , Oram Sian , Dale Oliver , Johnson Sonia 
Published: May 2022

Introduction
The need to improve the quality of community mental health services for people with Complex Emotional Needs (CEN) (who may have a diagnosis of ‘personality disorder’) is recognised internationally and has become a renewed policy priority in England. Such improvement requires positive engagement from clinicians across the service system, and their perspectives on achieving good practice need to be understood.

Aim
To synthesise qualitative evidence on clinician perspectives on what constitutes good practice, and what helps or prevents it being achieved, in community mental health services for people with CEN.

Methods
Six bibliographic databases were searched for studies published since 2003 and supplementary citation tracking was conducted. Studies that used any recognised qualitative method and reported clinician experiences and perspectives on community-based mental health services for adults with CEN were eligible for this review, including generic and specialist settings. Meta-synthesis was used to generate and synthesise over-arching themes across included studies.

Results
Twenty-nine papers were eligible for inclusion, most with samples given a ‘personality disorder’ diagnosis. Six over-arching themes were identified: 1. The use and misuse of diagnosis; 2. The patient journey into services: nowhere to go; 3. Therapeutic relationships: connection and distance; 4. The nature of treatment: not doing too much or too little; 5. Managing safety issues and crises: being measured and proactive; 6. Clinician and wider service needs: whose needs are they anyway? The overall quality of the evidence was moderate.

Discussion
Through summarising the literature on clinician perspectives on good practice for people with CEN, over-arching priorities were identified on which there appears to be substantial consensus. In their focus on needs such as for a long-term perspective on treatment journeys, high quality and consistent therapeutic relationships, and a balanced approach to safety, clinician priorities are mainly congruent with those found in studies on service user views. They also identify clinician needs that should be met for good care to be provided, including for supervision, joint working and organisational support.
Prevalence and risk factor for mistreatment in childbirth: In health facilities of Gondar city, Ethiopia
Authors: Shemelis Dagmawit , Gelagay Abebaw Addis , Boke Moges Muluneh 
Published: May 2022

Background
Providing compassionate and respectful maternity care to mothers is a vital intervention to improve health outcomes of women and newborns. However, there is less data of compassionate and respectful maternity care in Gondar city. Therefore, this study aimed to assess the magnitude of mistreatment and associated factors among mothers who gave birth at the public health facilities in Gondar city, northwest Ethiopia.

Methods
Institutional based cross-sectional study was conducted from March to April 2019 in Gondar city public nine health facilities. A total of 584 randomly selected women in the postpartum period were recruited in this study. A binary logistic regression analysis was done to see whether there was an association between mistreatment and independent variables. Finally, the logistic regression analysis was done by stratifying type of parity and mode of delivery.

Results
Overall, 73.2% (95% CI: 69.7–76.7%) of the women were mistreated during their childbirth care. Non-consented care was the most commonly experienced form of mistreatment (63.6%, 95% CI: 59.6–67.6%). Having less than four antenatal care follow-up visits (AOR = 3.58, 95% CI: 2.04–6.29), giving birth in the hospital (AOR = 2.83, 95% CI: 1.52–5.27), and facing complications during delivery (AOR = 2.06, 95% CI: 1.52–3.98) were significantly associated with mistreatment among postpartum mothers.

Conclusions
This study showed a lower proportion of mistreatment than other studies in Ethiopia. Having less than four ANC follow up, place of current delivery, and facing complication during delivery were identified as the determinants of mistreatment. Therefore, this calls for strengthening actions, like providing maternity education during antenatal care and appropriate management of complications to improve the quality of maternity care at health facilities, and enhancing hospital working health workers capacity on compassionate and respectful maternity care.