bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermediate to Long-Term Outcomes and Causes of Aseptic Failure of an At-Risk Femoral Stem
Authors: Gazendam Aaron , Ekhtiari Seper , Wood Thomas J. ,   the Hamilton Arthroplasty Group
Published: February 2022

Background:
The Accolade TMZF is a tapered-wedge cementless metaphyseal-coated femoral stem that was widely utilized from 2002 to 2012. In recent years, there have been reports of early catastrophic failure of this implant. The purposes of the present study were to establish the long-term survival of this stem and to analyze patients who underwent aseptic revision to understand the causes and risk factors for failure.

Methods:
We retrospectively reviewed the records of all patients who had undergone primary total hip arthroplasty with use of an Accolade TMZF stem at a high-volume arthroplasty center. The causes and timing of revision surgery were documented. Survivorship analysis was performed with use of Kaplan-Meier curves to determine the overall and aseptic survival rates at the time of the latest follow-up. Patient and implant factors commonly associated with aseptic failure were extracted, and a Cox proportional hazards model was used.

Results:
A consecutive series of 2,609 patients who had undergone unilateral primary total hip arthroplasty with use of an Accolade TMZF femoral stem were included. The mean time from the primary procedure was 11.3 years (range, 0 days to 19.4 years). The cumulative survival rate was 95.5% ± 0.1% at the time of the latest follow-up. One hundred and seven patients underwent revision surgery, with aseptic loosening of the femoral component being the most common cause of aseptic failure in this cohort (33 of 2,609; 1.3%). Smaller femoral size and larger femoral head offset were independent risk factors for aseptic failure.

Conclusions:
To our knowledge, this is the largest series representing the longest follow-up of this tapered-wedge cementless femoral implant. Despite early concerns, the Accolade TMZF stem had excellent survivorship in this cohort. Trunnionosis as the cause for revision surgery was rare.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
From Crisis To Crisis: Impacts Of The COVID-19 Pandemic On People Living With HIV And AIDS Service Organizations In Indiana
Authors: MacNeill Justin J , Linnes Jacqueline C , Rodriguez Natalia M 
Published: February 2022

Abstract
Background: The COVID-19 pandemic thrust people living with HIV (PLWH) and HIV/AIDS service organizations into an environment ripe with uncertainty. This study examined Indiana AIDS services provider perceptions of how COVID-19 affected the overall health and access to care of their clients, and how the organizations prepared for, adapted, and responded to the needs of PLWH during the pandemic. Methods: Guided by the socioecological model, fifteen semi-structured interviews were conducted with ten different HIV/AIDS service organizations across the state of Indiana. Results: Despite the profound disruptions experienced by HIV programs, HIV/AIDS service organizations responded quickly to the challenges posed by the COVID-19 pandemic through myriad innovative strategies, largely informed by prior experiences with the HIV epidemic. Conclusions: The lessons provided by HIV/AIDS service organizations are invaluable to informing future pandemic response for PLWH. Service delivery innovations in response to the COVID-19 crisis may provide insights to improve HIV care continuity strategies for vulnerable populations far beyond the pandemic.
A new modified Duckett urethroplasty for repair of proximal hypospadias with severe chordee: outcomes of 133 patients
Authors: Wang Chong , Zhang Zhi-Cheng , Zhang De-Ying , Hua Yi , Liu Feng , He Da-Wei , Wei Guang-Hui , Liu Xing 
Published: February 2022

Abstract
Purpose: To evaluate the indications and postoperative complications of our new modified Duckett urethroplasty.Methods: A total of 133 patients with proximal hypospadias who underwent repair of the modified Duckett urethroplasty from February 2016 to February 2021 were reviewed. The median age of patients was 3 years (range 1-16). All patients had severe chordee. One senior experienced pediatric urologist performed all the surgeries. Catheter was removed 14 days after the surgery.Results: The location of the urethral meatus was proximal penile in 26 patients (19.5%), penoscrotal in 60 (45.1%), scrotal in 31 (23.3%), and perineal in 16 (12.0%). The mean length of the urethral defect was 4.5 cm (range 2.5-10). The median duration of follow-up was 46 months (range 8-67). Complications occurred in 31 patients (23.3%), including urethra-cutaneous fistula in 22 (16.5%), urethral stenosis in 7 (5.3%), and urethral diverticulum in 2 (1.5%). No recurrent chordee were found in all cases. All patients who developed complications were treated successfully at our hospital. Conclusion: Our modified Duckett urethroplasty showed functionally and cosmetically favorable outcomes, with a lower incidence of postoperative complications. To the best of our knowledge, the novel Duckett technique is a feasible and suitable option for patients who suffer from proximal hypospadias with severe chordee and dysplasia of the urethral plate.
Quality of life assessment after total knee arthroplasty in patients with Parkinson’s disease
Authors: Zong Yaqi , Hao Congqiang , Zhang Yingjian , Wu Shuwen 
Published: February 2022

Abstract
Background: The number of Parkinson's patients (PD) undergoing total knee arthroplasty (TKA) is increasing. The purpose of the study was to characterize quality of life (QOL) outcomes for patients with coexisting PD and knee osteoarthritis (KOA) following TKA.Methods: Patients with coexisting PD and KOA undergoing TKA between June 2014 and June 2020 were included. These patients were matched to controls with KOA alone by age, gender, basic social background information and Knee society score（KSS）. The primary measure was to assess the QOL by the absolute changes in the EuroQOL5-Dimensions (EQ-5D), Pain and Disability Questionnaire (PDQ), and Patient Health Questionnaire-9(PHQ-9) at the last follow-up (LFU). Secondary measures were changes in QOL that exceeded the minimum clinically important difference value (MCID). Data on the health status and QOL of all patients were collected. Simple and multivariate regression analysis was used to evaluate the impact of PD on their QOL.Results: Twelve KOA patients with PD were compared with 48 controls. Control patients experienced QOL improvement across all three measures：EQ-5D index (0.545-0.717, P <0.01), PDQ (81.1-52.3, P < 0.01) and PHQ-9(8.22-5.91, P < 0.01) were significantly improved at the LFU; while in patients with PD, only PDQ (91.0-81.4, P =0.03) slightly improved. There were significant differences in the improvement of QOL between PD patients and the control group through EQ-5D (0.531 vs.0.717, P< 0.01) and PDQ (81.4vs.52.3, P <0.01) at the LFU.Conclusion: TKA has no benefit of QOL beyond a slight improvement in pain-related disability in the KOA patients with PD.
Loss of Control Eating During Pregnancy is Associated With Excessive Gestational Weight Gain Among Individuals With Overweight and Obesity
Authors: Levine Michele , Emery Rebecca L. , Conlon Rachel , Grace Jennifer , Sweeny Gina M. , Wang Bang , Cheng Yu 
Published: February 2022

Abstract
Purpose: Excessive gestational weight gain (GWG) predicts negative health outcomes among individuals with overweight or obesity. Loss of control eating (LOC), the ingestion of food associated with being unable to control eating, is the core psychopathology of binge eating disorders. We evaluated the contribution of LOC to GWG among pregnant individuals with prepregnancy overweight/obesity. Methods: In a prospective longitudinal study, individuals with prepregnancy BMI≥ 25 (N=257) were interviewed monthly to assess LOC and reported demographic, parity and smoking information. GWG was abstracted from medical records. Results: Among individuals with prepregnancy overweight/obesity, 39% endorsed LOC prior to or during pregnancy. After adjusting for factors that have previously been linked to GWG, LOC during pregnancy, uniquely predicted higher GWG and greater likelihood of exceeding GWG recommendations. Participants with prenatal LOC gained 3.14kg (p=0.03) more than did those without LOC during pregnancy and 78.7% (n = 48/61) exceeded IOM guidelines for GWG. The frequency of LOC episodes was also associated with greater weight gain.Conclusions: Prenatal LOC is common among pregnant individuals with overweight/obesity and predicts greater GWG and increased likelihood of exceeding IOM GWG guidelines. LOC may represent a modifiable behavioral mechanism to prevent excessive GWG among individuals at risk for adverse pregnancy outcomes.
Forecasting GDP Growth using Financial Information
Authors: SENE Mamadou Ndiaye 
Published: February 2022

Abstract
The shocks that occur in periods of instability in financial markets affect the effective implementation that would be subject to appropriate macroeconomic policies. Researchers have developed several approaches to monitor macroeconomic policies concerned with the goal of stabilizing and strengthening the global financial system. The 2007 financial crisis revealed the limits of the proposed approaches, which designed to analyze and forecast the economic fluctuations. Other approaches, including the mixed frequency data models, have been put forward to address the limitations the existing forecasting models by taking into account the interactions between the real and financial sectors. The information on the equity and commodity markets increase the predictive capacities of models and thereby can be used to forecast the fluctuations of GDP growth. The present paper applies a modelindependent data assimilation (MIDAS), which is embedded in the mixed frequency data models, to forecast the fluctuations in the economic growth of five developed countries, namely the United States, France, Germany, United Kingdom and Japan. The results show that, taking into account the volatility of financial market indicators enable to provide accurate projections of the economic growth. Furthermore, the integration of the autoregressive component in the MIDAS model strengthens its predictive capacity over the forecast period.
Implications of Additivity and Nonadditivity for Machine Learning and Deep Learning Models in Drug Design
Authors: Kwapien Karolina , Nittinger Eva , He Jiazhen , Margreitter Christian , Voronov Alexey , Tyrchan Christian 
Published: February 2022

Abstract
Matched molecular pairs (MMPs) is nowadays a commonly applied concept in drug design. It is used in many computational tools for structure activity relationship analysis, biological activity prediction or optimization of physicochemical properties. However, up to date it has not been shown in a rigorous way that MMPs, i.e. changing only one substituent between two molecules, can be predicted with high accuracy and precision in contrast to any other chemical compound pair. It is expected that any model should be able to predict such a defined change with high accuracy and reasonable precision. In this study, we examine the predictability of four classical properties relevant for drug design ranging from simple physicochemical parameters (logD and solubility) to more complex cell based ones (permeability and clearance), using different data sets and machine learning algorithms. Our study confirms that additive data is the easiest to predict which highlights the importance of recognition of nonadditivity events and the challenging complexity of predicting properties in case of scaffold hopping. Despite of deep learning being well suited to model non-linear events, these methods do not seem to be an exception of this observation. Though, they are in general performing better than classical machine learning methods, this leaves the field with a still standing challenge.
The Associations Between Lung Function And Rapid Eyes Movement Sleep In Healthy Adults: A Population-Based Cohort Study In Southwest China
Authors: Peng Anjiao , Yang Danxuan , Li Wanling , Dong Bosi , Lai Wanlin , Wang Mingda , Zhu Yuanfeng , Chen Lei 
Published: February 2022

Abstract
Background: To explore and understand associations between lung function and sleep architectures in healthy adults. Methods: Seventy-two participants (mean age 55.9 years, 72.2% female) were recruited from the Southwest China cohort study conducted at the West China hospital. Forced expiratory volume in first second (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) were measured using a spirometer for all participants. Participants’ objective sleep architectures, including sleep duration, rapid eye movement (REM) time, light and deep sleep were monitored using a Doppler radar sensor. Linear regression was used to analyze the associations between lung function measures and sleep architecture.Results: Results for FEV1/FVC were found to be positively correlated with REM sleep time (β = 0.29, p = 0.013). There was no positive correlation with sleep duration (p = 0.44 ), light sleep (p = 0.83) or deep sleep (p = 0.60) in regression model, including the use of lung function as the only predictor. Results for FEV1 demonstrated a tendency of positive correlation with REM sleep (β = 0.22, p = 0.07 ) and deep sleep (β = 0.21, p = 0.073), but it was not associated with sleep duration (p = 0.53) or light sleep (p = 0.54). After adjusting for all confounders, the results of FEV1/FVC remained positively correlated with REM sleep time (β = 0.28, p = 0.028). Conclusion: Our findings further confirmed that lung function is closely related to sleep architectures in healthy population, particularly, the result for FEV1/FVC is positively correlated with REM sleep.
Altemeier and Delorme procedures are efficacious and safe for treatment of Rectal Prolapse:A Retrospective Analysis
Authors: Wang HouDong , Zhang Xiu-Feng , Shao Shu-Xian , Shen Zhong 
Published: February 2022

Abstract
Purpose To compare the safety and efficacy of Altemeier and Delorme procedures for treatment of mild full-thickness rectal prolapse. Methods A total of 34 patients, diagnosed with rectal prolapse and who underwent Altemeier and Delorme procedures between January 2011 to December 2019, were included in the study. We evaluated each patient’s clinical characteristics, operative outcomes and follow-up data then compared them between groups. Results Both procedures were successfully completed in all recruited patients, with no significant differences observed between the groups with regards to age, sex, disease course, body mass index (BMI) and American Society of Anesthesiologist (ASA) score (p > 0.05). However, squat maximal prolapse length was significantly lower in Delorme (5.4±1.6 cm) than in the Altemeier (9.3±2.3 cm) group (t=5.89, p＜0.01). Similarly, operative time was significantly shorter in the Delorme (85.8±13.7 min) than in the Altemeier (111.0±14.2 min; t=5.26, p＜0.01) group, while intraoperative blood loss was significantly lower in the Delorme (20.8±6.5 ml) than Altemeier (61.7±9.4 ml, t=14.98, p<0.01). However, we found no significant differences in the incidence of postoperative complications, including bleeding, anastomotic stricture, anastomotic leakage, urinary retention, urinary tract infection between the Delorme (16%) and Altemeier (20%) groups (P=0.10, p= 0.75). Notably, patients in the Delorme group had significantly shorter postoperative hospital stay (8.4±1.5 days) relative to those in the Altemeier group (11.0±2.2 days) (t=4.13, p ＜0.01). We found no significant differences in follow-up times between Delorme (16.3±2.3 months) and Altemeier (15.0±3.3 months) groups (t=1.38, p = 0.18), as well as overall success rates (Delorme =89.5%; Altemeier =86.7%,u=0.06, p= 0.80). A total of 5 and 4 patients from the Delorme and Altemeier groups, respectively, exhibited constipation symptoms. Compared with before operation, the Wexner constipation score decreased in both groups (Delorme=23.6±2.5 vs.11.0±2.0, t=24.71, p＜0.01; Altemeier=23.5±1.3 vs.9.3±1.7,t=13.83, p＜0.01). Moreover, fecal incontinent symptoms were described in 6 and 5 patients of Delorme group and Altemeier group, respectively. Postoperative Wexner fecal incontinence scale scores were significantly lower in the two groups than those before operation (Delorme=14.8±1.5 vs.6.2±0.8, t=14.10, p＜0.01; Altemeier=15.6±1.1 vs.6.8±2.3,t=10.23，p＜0.01).Conclusion Our results affirm the efficacy and safety of both Altemeier and Delorme procedures in treatment of rectal prolapse, for improved defecation status in patients with faecal incontinence and constipation. Delorme procedure is recommended for patients with mild prolapse, owing to quicker recovery, shorter hospital stay, and fewer anastomotic complications, relative to Altemeier.
Glucose-6-Phosphate Dehydrogenase is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma
Authors: Liu Kejun , Niu Yiming , Hao Ji , Cui Lei , Li Cunquan , Chen Bendong , Bu Yang 
Published: February 2022

Abstract
Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in the metabolic and immunological aspects of tumors. In hepatocellular carcinoma (HCC), the alteration of tumor microenvironment influences recurrence and metastasis. We extract G6PD expression information from TCGA and GEO databases in liver cancer tissues and normal tissues, validated by immunohistochemistry, and the correlation between G6PD expression and clinical features is analyzed, and the clinical significance of G6PD in liver cancer is assessed by Kaplan-Meier, Cox regression and prognostic line graph models. Functional enrichment analysis is performed by protein-protein interaction (PPI) network, GO/KEGG, GSEA and G6PD-associated differentially expressed genes (DEGs). TIMER and ssGSEA packages are used to assess the correlation between expression and the level of immune cell infiltration. Analysis of TCGA and GEO datasets revealed that G6PD expression is significantly upregulated in hepatocellular carcinoma tissues (P < 0.001). G6PD expression is associated with histological grade, pathological stage, T-stage, vascular infiltration and AFP level (P < 0.05); HCC patients in the low G6PD expression group had longer overall survival and better prognosis compared with the high G6PD expression group (P < 0.05). The level of G6PD expression affects the levels of macrophages, unactivated dendritic cells, B cells, and follicular helper T cells in the tumor microenvironment. High expression of G6PD is a potential biomarker for poor prognosis of hepatocellular carcinoma, and G6PD may be a target for immunotherapy of HCC.
Network Analysis for Directing Standardization Efforts in Genomics Using MEDLINE
Authors: Bae Eun Bit , Nam Se Jin , Lee Sungin , Ahn Sun-Ju 
Published: February 2022

Abstract
Background: Biotechnology in genomics, such as sequencing devices and gene quantification software, has proliferated and been applied to clinical settings. However, the lack of standards applicable to it poses practical problems in interoperability and reusability of the technology across various application domains. This study aims to visualize and identify the standard trends in clinical genomics and to suggest areas on which standardization efforts must focus. Methods: Of 16,538 articles retrieved from PubMed, published from 1975 to 2020, using search keywords “genomics and standard” and “clinical genomic sequence and standard”, terms were extracted from the abstracts and titles of 15,855 articles. Our analysis includes 1) keyword-based network analysis, considering the characteristics of keyword clusters; 2) period analysis with six phases; 3) statistical analysis; 4) content analysis.Results: Our research trend showed an increasing trend from 2003, years marked by the completion of the human genome project (2003). The content analysis showed that keywords related to such concepts as gene types for analysis, and analysis techniques were increased in phase 3 when US-FDA first approved the next-generation sequencer. During 2017-2019, oncology-relevant terms were clustered and contributed to the increasing trend in phase 4 of the content analysis. In the statistical analysis, all the categories showed high regression values (R2>.586) throughout the whole analysis period and phase-based statistical analysis showed significance only in Genetics terminology category (P=.039*) at phase 4.Conclusions: This study investigated, through the network and statistical analysis, trend shifts in relation to clinical genomics. The shifts offer a solid basis for standards development that shows where future standardization opportunities and gaps lie.
The effect of crossbreeding by the Montbeliard cattle on the transcriptome of the Sistani cattle
Authors: Esfedan Batol Asghari , Dashab Gholam Reza , Banabazi Mohammad Hossein , Rokouei Mohammad 
Published: February 2022

Abstract
Objective: Transcriptome study of the desired crossbreed and comparing it with the pure parental population is a method for evaluating and selecting cross with appropriate products, yet disease resistance, high tolerance to environmental stresses, and compatibility with the climate of the breeding tract. RNA-Sequencing (RNA-seq) technology was employed to investigate the effect of crossbreeding by the Montbeliard cattle on the “Sistani cattle” transcriptome. Blood samples were collected from 90 cows (45 pure and 45 crossbreeds). Total RNA was extracted in the Media Teb Gene Laboratory of Iran. The mRNA selection, library preparation, and sequencing were performed at BGI Shenzhen, China on an Illumina HiSeq 2500 sequencer. After assembling the transcripts with the bovine reference genome, Cuffdiff was used to detect differential gene expression in purebred and its crossbred.Results: In total, 45 signiﬁcantly differentially expressed genes were identified (false discovery rate q< 0.05) between purebred Sistani and “Sistani×Montbeliard” crossbreed. These genes are reported to have a role in immune response, calving, fertility, and resistance to mastitis. Besides, they may have a role in different levels of heat tolerance and disease resistance. Therefore, Sistani×Montbeliard crossbred might be suitable for the climatic conditions of the Sistan region in Iran.
Method for engineering artificial bidirectional promoters
Authors: Fages-Lartaud Maxime , Prone Weiyan , Mueller Yasmin , Lale Rahmi 
Published: February 2022

Abstract
Bidirectional promoters (BDPs) are ubiquitous as they facilitate gene co-expression within functional groups of genes or metabolic pathways. They help to balance enzymatic expression to maintain a stoichiometric relationship and avoid cellular toxicity. While BDPs offer several benefits over single-gene expression cassettes, functionally defined BDPs are scarce and usually unsuited for multi-gene expression in synthetic biology and metabolic engineering efforts. In this paper, we describe the fabrication of BDPs in bacteria using DNA with a random nucleotide composition. We created 230 artificial BDPs using a direct selection method (antibiotic resistance) and 168 gene-specific BDPs using a double fusion protein device (fluorescent reporters along with antibiotic resistance). The method's simplicity, gene-specificity, and universality make it an unprecedented tool for creating artificial BDP libraries representing a wide range of expression levels. This technique addresses the challenges in obtaining balanced co-expression of heterologous genes or pathways in various hosts. Furthermore, it provides insights that help to understand the architecture and features of BDPs.